bluuebunny/crossref_metadata_2025_split huggingface dataset:
Los conflictos socio ambientales en la arena judicial en Argentina: diseños institucionales para la decisión judicial de base científica
Authors: Sozzo Gonzalo 
Published: April 2022

This article addresses the problem of the necessary articulation between scientific knowledge and judicial decision in Argentina in cases where there is uncertainty about risks to human health and ecosystems, which requires the application of the precautionary principle. My thesis is that in Argentina there are two key issues for proper articulation that have not yet been properly addressed, which constitutes a serious obstacle to judicial decision-making in socio-environmental conflicts: (1) the absence of institutional rules to organize a precautionary scientific expert test; (2) the lack of institutional rules that establish the conditions for admitting the consideration of scientific evidence in judicial processes to the fines of clearing or not the uncertainty around the existence of a risk.
Este artículo aborda el problema de la necesaria articulación entre conocimiento científico y decisión judicial en Argentina en los casos en los que existe incertidumbre en torno a riesgos para la salud humana y los ecosistemas, lo que exige la aplicación del principio precautorio. Mi tesis es que en Argentina hay dos tópicos claves para la adecuada articulación que no han sido aun correctamente abordados, lo cual constituye un grave obstáculo para la toma de decisiones judiciales en los conflictos socio ambientales: (1) la ausencia de reglas institucionales para organizar una prueba pericial científica precautoria; (2) la falta de reglas institucionales que establezcan las condiciones para la admitir la consideración de pruebas científicas en los procesos judiciales a los fines de despejar o no la incertidumbre en torno a la existencia de un riesgo.
The confidence‐accuracy relation – A comparison of metacognition measures in lie detection
Authors: Volz Sarah , Reinhard Marc‐André , Müller Patrick 
Published: April 2022

AbstractPrevious research has produced mixed results on the question of whether confidence in ad hoc veracity judgments can be used as an indicator of judgment accuracy. These studies have used a variety of measures to analyze the confidence‐accuracy relationship; however, they have rarely explicitly addressed why a particular measure was chosen and what its properties are. We theoretically and empirically examined previously used measures of metacognition in lie detection and report the results these measures yielded in re‐analyses of 12 lie detection studies (total N = 2817 participants). Regardless of the measure, none of the studies found a confidence‐accuracy relationship. Discrepancies between the measures are likely due to conceptual differences between them, emphasizing the importance of carefully selecting appropriate measures for the research question at hand. More work on the underlying processes of confidence judgments in lie detection is needed to improve the assessment of confidence and the selection of appropriate measures.
A Polystyrene Photoresin for Direct Lithography of Microfluidic Chips
Authors: Franco Corredor Santiago , Mayoussi Fadoua , Luitz Manuel , Kick Andrea , Goralczyk Andreas , Böcherer David , Vera Grace , Helmer Dorothea , Kotz‐Helmer Frederik , Rapp Bastian E. 
Published: April 2022

AbstractPolystyrene (PS) is the material of choice for many medical, biological, and biomedical applications given its advantageous properties such as high biocompatibility, optical transparency, and the possibility to shape PS using high‐throughput manufacturing methods at low production costs. Due to its properties, PS is an interesting material for the fabrication of microfluidic systems. In microfluidics, rapid prototyping is of high importance for testing new chip layouts and designs during the product development with the aim of significantly accelerating the manufacturing. To allow transitioning and thus significantly faster translation from research to scalable manufacturing, it would be ideal if the same material could be used throughout the whole design pipeline. However, rapid prototyping and high‐resolution shaping of PS, especially on the micron scale, is still limited. In this work,a novel photocurable polystyrene photoresin, is presented which can be shaped using direct optical lithography. Using this PS photoresin, microfluidic chips with feature sizes down to 50 µm and a high optical transparency can be fabricated. The cured PS photoresin shows comparable surface and material properties to commercial PS. This method will enable researchers in the medical, biological and biomedical fields to produce suitable PS structures with commercial equipment.
Additive Manufacturing of 3D Luminescent ZrO2:Eu3+ Architectures
Authors: Winczewski Jędrzej , Herrera Manuel , Cabriel Clément , Izeddin Ignacio , Gabel Stefan , Merle Benoit , Susarrey Arce Arturo , Gardeniers Han 
Published: April 2022

AbstractImplementation of more refined structures at the nano to microscale is expected to advance applications in optics and photonics. This work presents the additive manufacturing of 3D luminescent microarchitectures emitting light in the visible range. A tailor‐made organo‐metallic resin suitable for two‐photon lithography is developed, which upon thermal treatment in an oxygen‐rich atmosphere allows the creation of silicon‐free tetragonal (t‐) and monoclinic (m‐) ZrO2. The approach is unique because the tailor‐made Zr‐resin is different from what is achieved in other reported approaches based on sol−gel resins. The Zr‐resin is compatible with the Eu‐rich dopant, a luminescent activator, which enables to tune the optical properties of the ZrO2 structures upon annealing. The emission characteristics of the Eu‐doped ZrO2 microstructures are investigated in detail with cathodoluminescence and compared with the intrinsic optical properties of the ZrO2. The hosted Eu has an orange−red emission showcased using fluorescence microscopy. The presented structuring technology provides a new platform for the future development of 3D luminescent devices.
Investigation of water kinetics in zeolite Linde‐Type‐A crystals by a concentration‐swing frequency response
Authors: Wang Yu , Strohmaier Karl , Strasser Michael 
Published: April 2022

AbstractA new concentration‐swing frequency response system was developed to evaluate water kinetics in non‐binder containing zeolite Linde Type A (LTA) crystals with frequencies up to 1 Hz. For commercial micron‐sized 3A crystals, the mass transfer rate is too fast to be determined accurately due to reduced sensitivity near the system limits. Larger LTA crystals (~15 μm) were synthesized in house and ion exchanged to three potassium concentrations (0, 48, and 77 wt%) to aid in the accurate determination of mass transfer mechanism and rates. Micropore diffusion with parallel sites, not a surface barrier, described all the data well, consistent with the bimodal distribution of crystal sizes from scanning electron microscope images. The transport diffusivity for water in zeolite 3A crystals near saturated loadings at 25°C is about 1 × 10−12 m2/s, 10 times slower than 4A crystals around 10−11 m2/s, both supporting fast micropore diffusion time constants >1 s−1 for micron‐sized crystals.
TRDMT1 exhibited protective effects against LPS‐induced inflammation in rats through TLR4‐NF‐κB/MAPK‐TNF‐α pathway
Authors: Li Zhengguang , Qi Xiaolong , Zhang Xu , Yu Lei , Gao Lijuan , Kong Weining , Chen Wei , Dong Wei , Luo Lijun , Lu Dan , Zhang Lianfeng , Ma Yuanwu 
Published: April 2022

AbstractBackgroundInflammation is a complex physiological and pathological process. Although many types of inflammation are well characterized, their physiological functions are largely unknown. tRNA aspartic acid methyltransferase 1 (TRDMT1) has been implicated as a stress‐related protein, but its intrinsic biological role is unclear.MethodsWe constructed a Trdmt1 knockout rat and adopted the LPS‐induced sepsis model. Survival curve, histopathological examination, expression of inflammatory factors, and protein level of TLR4 pathway were analyzed.ResultsTrdmt1 deletion had no obvious impact on development and growth. Trdmt1 deletion slightly increased the mortality during aging. Our data showed that Trdmt1 strongly responded in LPS‐treated rats, and Trdmt1 knockout rats were vulnerable to LPS treatment with declined survival rate. We also observed more aggravated tissue damage and more cumulative functional cell degeneration in LPS‐treated knockout rats compared with control rats. Further studies showed upregulated TNF‐α level in liver, spleen, lung, and serum tissues, which may be explained by enhanced p65 and p38 phosphorylation.ConclusionsOur data demonstrated that Trdmt1 plays a protective role in inflammation by regulating the TLR4‐NF‐κB/MAPK‐TNF‐α pathway. This work provides useful information to understand the TRDMT1 function in inflammation.
A rational study on the hydrothermal aging of AFP manufactured CF/polyetherketoneketone composites with in situ consolidation supported by acoustic emission inspection
Authors: Sukur Emine Feyza , Elmas Sinem , Seyyednourani Mahsa , Eskizeybek Volkan , Yildiz Mehmet , Sas Hatice S. 
Published: April 2022

AbstractIn this study, carbon fiber (CF)/polyetherketoneketone (PEKK) composites with 5% void content, manufactured via an in situ consolidated automated fiber placement (AFP) lay‐up process, are aged in hot water at 70°C for 30 days. Firstly, a deep understanding of the deterioration in the mechanical performance is developed with a comprehensive and complementary set of material characterization strategies, including (i) microstructural characterization with Fourier‐transform infrared spectroscopy (FTIR), (ii) thermal characterization with differential scanning calorimetry (DSC), and (iii) dynamic mechanical analysis (DMA). The material characterization concurrently highlights the plasticization and post‐crystallization phenomena after aging with changes in the peak densities with FTIR, formation of second glass transition temperature (Tg) in DSC and DMA, and drop in storage modulus, loss modulus, and tan delta (δ) amplitudes. Then, acoustic emission (AE) is utilized as an inspection tool to identify the damage mechanisms regarding the 6.5%, 5.2%, and 4% decrease in tensile strength, strain at failure and modulus, respectively, in a comparative manner. The AE findings, remarking the weakening of the fiber–matrix interface after aging, are validated with scanning electron microscopy analysis. This study introduces an aging process‐induced damage mechanism triggered with inhomogeneous water absorption for AFP manufactured CF/PEKK composites with in situ consolidation.
S‐adenosyl methionine improves motor co‐ordination with reduced oxidative stress, dopaminergic neuronal loss, and DNA methylation in the brain striatum of 6‐hydroxydopamine‐induced neurodegeneration in rats
Authors: Jalgaonkar Sharmila , Gajbhiye Snehalata , Sayyed Mohsin , Tripathi Raakhi , Khatri Nishtha , Parmar Urwashi , Shankar Arun 
Published: April 2022

AbstractPurposeParkinson's disease (PD) is the most common age‐related neurodegenerative disease worldwide. S‐adenosyl methionine (SAMe), a methyl donor that plays an important role in DNA methylation, could replenish the cellular antioxidant glutathione (GSH). Herein, we investigated the neuroprotective effects of SAMe in 6‐hydroxydopamine (6‐OHDA) rat models of PD and elucidated the underlying mechanism.MethodsPD model rats were developed by injecting 6‐OHDA stereotaxically into the striatum. In Phase 1 of the study, we performed the neurobehavioral tests, GSH assay, and histopathology to evaluate the neuroprotective effects of SAMe. The animals were treated with SAMe (150 or 300 mg/kg body weight) orally for 28 days. The positive control group received selegiline (5 mg/kg), whereas the disease control group received normal saline.In Phase 2, we evaluated the striatal dopamine levels and performed DNA methylation assay to uncover the mechanism of action of SAMe. In this phase, a higher dose of SAMe (300 mg/kg) was used.ResultsSAMe (300 mg/kg) treatment for 4 weeks significantly attenuated the abnormal circling behavior in PD rats (p < 0.05). Moreover, SAMe at both doses (150 and 300 mg/kg) enhanced the performance of PD rats in the open field test and stepping test (p < 0.05). SAMe treatment significantly increased the GSH levels, and at high dose, SAMe restricted neuronal loss in the striatum of PD‐model rats (p < 0.05). Moreover, SAMe treatment led to a significant recovery in the dopamine levels and improved the DNA methylation status in the dopaminergic neurons (p < 0.05) of PD model rats.ConclusionSAMe exhibits antioxidant activity and DNA methylation modulating effects in 6‐OHDA model PD rats. Moreover, SAMe prevents neuronal loss in PD rats suggesting that SAMe has therapeutic potential in preventing PD development. The neuroprotective potential of SAMe is greater at high doses.
Modulating the Intrinsic Electrocatalytic Activity of Copper Sulfide by Silver Doping for Electrocatalytic Overall Water Splitting
Authors: Chinnadurai Deviprasath , Manivelan Nandapriya , Prabakar Kandasamy 
Published: April 2022

AbstractHighly efficient and cost‐effective electrocatalysts towards bifunctional oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) are critical for industrial scale and environmentally friendly electrocatalytic production. Herein, we attempt to synthesize a low‐cost copper sulfide bifunctional electrocatalyst and modulated the intrinsic electrocatalytic activity by silver doping at desired amounts by a facile chemical bath deposition technique. The intrinsic activity of the CuS by Ag doping was closely monitored and presented with detailed OER and HER electrochemical characterizations. Finally, the optimized overall water splitting electrolyzer with a doping level of Ag 10 % exhibited a relatively low cell voltage of 1.55 V at a current density of 10 mA/cm2. The surface having Ag1+ and Cu1+ oxidation states could effectively fetch electrons from OH− species leading to higher intrinsic activity. The stability of the best electrocatalyst checked up to 40 hours at a high current rate of 200 mA/cm2 and shows a stable oxidation state. This work provides an important Ag doping strategy for bifunctional electrocatalyst to enhance their intrinsic catalytic activity for overall water splitting application.
Kalihioxepanes A—G: Seven Kalihinene Diterpenoids from Marine Sponge Acanthella cavernosa Collected off the South China Sea
Authors: Wang Zhe , Han Xiao , Liu Guoping , Zhang Di , Hou Huiyue , Xiao Li , de Voogd Nicole J. , Tang Xuli , Li Pinglin , Li Guoqiang 
Published: April 2022

Comprehensive SummarySeven new kalihinene diterpenoids, kalihioxepanes A—G (1—7) bearing a rare oxepane ring, were isolated from sponge Acanthella cavernosa collected from the South China Sea. The structures and absolute configurations were elucidated by comprehensive spectroscopic analysis, single crystal X‐ray diffraction, and quantum chemical calculation methods. Kalihioxepane A (1) displayed strong cytotoxicity against H69 and K562 tumor cells, while kalihioxepane B (2) showed moderate cytotoxicity against K562 cells.
Advances in Self‐Assembly of Metabolite Nanostructures: Physiology, Pathology and Nanotechnology
Authors: Shanker Tiwari Om , Rencus‐Lazar Sigal , Gazit Ehud 
Published: April 2022

AbstractMetabolites are immensely important for the routine function of every cell and take part in numerous physiological processes. Yet, in excess amounts, metabolites can self‐assemble, giving rise to cytotoxic amyloid‐like structures. Such structures may underlie some of the pathological effects associated with inborn error of metabolism disorders characterized by metabolite accumulation due to genetic mutations. Furthermore, such assemblies may have a role in neurodegenerative disorders due to abnormal accumulation. On the other hand, metabolites were shown to form functional assemblies in various organisms. Interestingly, various proteins and peptides showing amyloidal properties also have physiological roles and have been used for the fabrication of functional nanomaterials. Following this notion, metabolite self‐assembly could also be utilized due to several advantages including exceptional biocompatibility, inexpensive production, facile modeling and biodegradability in vivo. Co‐assembly of metabolites resulting in high rigidity can be further used in different biomedical and nanotechnological applications. Metal‐coordinated metabolite assemblies can be used as electrocatalysts in energy harvesting applications. Consequently, the study of metabolite self‐assemblies is not only crucial in order to understand their role in normal physiology and in pathology, but can also uncover a new route in exploring the fabrication of organic, biocompatible structures for material sciences and various technological applications.
Effects of pill colors on human perception and expectation of drugs' efficacy
Authors: Amawi Rema M. , Murdoch Michael J. 
Published: April 2022

AbstractThe physical appearance of pills, especially their color, affect expectations of their efficacy in addition to their intended medicinal effect. The purpose of this study is to understand the effects pill colors have on a wide variety of people, testing the hypotheses that the color of the pill affects participants' expectation of the drug's efficacy, and that demographics play a role in the participant's judgement. The 339 participants were recruited from the Rochester Institute of Technology global campuses in Rochester, USA, and Dubai, UAE. The study did not involve individuals taking drugs. Instead, it measured how people perceived the expected effects of pills on six efficacies, by asking the participants to rate the expected efficacy of five colors of pills. While there were some clear patterns and similarities in the results, differences were also apparent across the various demographics considered in this study. It is evident that three out of the six efficacies tested had a strong association with a particular color: stimulant efficacy with red, pain relief with white, and antacid with yellow. Remaining efficacies had weaker associations or varied associations based on different demographics. The patterns that emerged will help pharmaceutical companies, as well as medical practitioners, to better manufacture and prescribe drugs, thus maximizing the effects of the pills on patients overall, and increasing their compliance rates.
Network‐wise concordance of multimodal neuroimaging features across the Alzheimer's disease continuum
Authors: Stocks Jane , Popuri Karteek , Heywood Ashley , Tosun Duygu , Alpert Kate , Beg Mirza Faisal , Rosen Howard , Wang Lei ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: April 2022

AbstractBackgroundConcordance between cortical atrophy and cortical glucose hypometabolism within distributed brain networks was evaluated among cerebrospinal fluid (CSF) biomarker‐defined amyloid/tau/neurodegeneration (A/T/N) groups.MethodWe computed correlations between cortical thickness and fluorodeoxyglucose metabolism within 12 functional brain networks. Differences among A/T/N groups (biomarker normal [BN], Alzheimer's disease [AD] continuum, suspected non‐AD pathologic change [SNAP]) in network concordance and relationships to longitudinal change in cognition were assessed.ResultsNetwork‐wise markers of concordance distinguish SNAP subjects from BN subjects within the posterior multimodal and language networks. AD‐continuum subjects showed increased concordance in 9/12 networks assessed compared to BN subjects, as well as widespread atrophy and hypometabolism. Baseline network concordance was associated with longitudinal change in a composite memory variable in both SNAP and AD‐continuum subjects.ConclusionsOur novel study investigates the interrelationships between atrophy and hypometabolism across brain networks in A/T/N groups, helping disentangle the structure–function relationships that contribute to both clinical outcomes and diagnostic uncertainty in AD.
The moderating role of sleep duration on momentary relations between negative affect and loss‐of‐control eating in children and adolescents
Authors: Manasse Stephanie M. , Haedt‐Matt Alissa A. , Smith Kathryn E. , Egbert Amy H. , O’Sullivan Katie , Koren Dorit , Engel Scott , Goldschmidt Andrea B. 
Published: April 2022

AbstractObjectiveLoss‐of‐control (LOC) eating is associated with eating disorders and obesity, and thus it is imperative to understand its momentary risk factors in order to improve intervention efforts. Negative affect has been proposed as a momentary risk factor for LOC eating, but the evidence for its effects in children and adolescents is mixed. Short sleep duration (which is very common in youth), may be one variable that moderates the relation between negative affect and subsequent LOC eating. As such, we aimed to examine the moderating role of within‐person sleep duration on the momentary relations between negative affect and subsequent LOC eating.MethodWe recruited children (N = 30) with overweight/obesity ages 8‐14, who completed a 2‐week ecological momentary assessment protocol assessing negative affect and LOC eating several times per day, while also wearing a sleep actigraphy device and completing sleep diaries.ResultsConsistent with hypotheses, within‐person sleep duration moderated the next‐day momentary relation between within‐person negative affect and LOC eating, such that shorter sleep duration strengthened the positive relation between negative affect and loss‐of‐control eating.ConclusionsResults suggest that, in children and adolescents, fluctuations in sleep duration may influence susceptibility to losing control over eating after experiencing negative affect. Future research should further investigate other metrics of sleep disturbance as they relate to emotion regulation and LOC eating. Such research will set the stage for augmenting paediatric interventions to better target maintenance factors for LOC eating.
Ionic conductivity and ion transport mechanisms of solid‐state lithium‐ion battery electrolytes: A review
Authors: Yang Hui , Wu Nianqiang 
Published: April 2022

AbstractThis review article deals with the ionic conductivity of solid‐state electrolytes for lithium batteries. It has discussed the mechanisms of ion conduction in ceramics, polymers, and ceramic‐polymer composite electrolytes. In ceramic electrolytes, ion transport is accomplished with mobile point defects in a crystal. Li+ ions migrate mainly via the vacancy mechanism, interstitial mechanism, or interstitial‐substitutional exchange mechanism. In solid polymer electrolytes, Li+ ions are transported mainly via the segment motion, ion hopping (Grotthuss mechanism), or vehicle mechanism (mass diffusion). This study has also introduced various electrolyte materials including perovskite oxides, garnet oxides, sodium superionic conductors, phosphates, sulfides, halides, cross‐linked polymers, block‐copolymers, metal‐organic frameworks, covalent organic frameworks, as well as ceramic‐polymer composites. In addition, it has highlighted some strategies to improve the ionic conductivity of solid‐state electrolytes, such as doping, defect engineering, microstructure tuning, and interface modification.