bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Cardiovascular Disease in Psychiatric Patients: Machine Learning with Electronic Health Records
Authors: Bernstorff M. , Danielsen A. , Dinesen S. 
Published: September 2022

IntroductionCardiovascular disease (CVD) causes staggering losses in quality adjusted life years worldwide.1 Among patients in the Danish psychiatric hospital setting, heart disease is associated with a decrease in life expectancy of 5.1 years.2 The causes underlying this association are likely manifold. For example, severe mental illness is associated with unhealthy lifestyle.3 Furthermore, psychiatrists may focus predominantly on the treatment of mental illness and have less emphasis on detection and prevention of physical illness.4 If patients at elevated risk of CVD are pointed out automatically, this may lead to better preventive medicine.ObjectivesTo predict which patients develop cardiovascular disease using machine learning.MethodsWe obtained data on all psychiatric hospital contacts in the Central Denmark Region since the initiation of the current EHR system (MidtEPJ). These span from 2011 to 2021 and cover 120,000 patients, of which 3,000 patients developed severe CVD (stroke or coronary event) follow-up. We will train a variety of models (random forests, SVM, deep neural nets) to predict CVD within one year from a planned contact to hospital.ResultsThe modelling is currently underway, intermediary results are expected in January.ConclusionsWe explore whether predicting CVD is feasible using state-of-the-art technologies and a uniquely detailed dataset. This may pave the way for machine learning to act as a clinical support decision system, since we’re only training on data that is available in a live, clinical context.References1: Khan 20192: Erlangsen 20173: Scott 20114: Fagiolini 2009DisclosureNo significant relationships.
Individual-specific changes in circadian rest-activity rhythm and sleep in symptom-free patients tapering their antidepressant medication
Authors: Minaeva O. , Schat E. , Ceulemans E. , Kunkels Y. , Smit A. , Wichers M. , Booij S. , Riese H. 
Published: September 2022

IntroductionGroup-level studies showed cross-sectional and prospective between-person associations between circadian rest-activity rhythms (RAR), physical activity (PA), sleep, and depressive symptoms. However, whether these associations replicate at the within-person level remains unclear. Therefore, it is clinically relevant to investigate these associations within persons and study whether changes in depressive symptoms are related to changes in circadian rhythm and sleep variables.ObjectivesTo identify changes in circadian rhythm elements in proximity to a transition in depressive symptoms, whether changes are less frequent in individuals without compared to those with transitions, and whether there are individual differences in the direction of change of circadian rhythm variables.MethodsData of remitted individuals tapering antidepressants were used: 12 with and 14 without a transition in depressive symptoms. RAR, PA, and sleep variables were calculated as predictors from four months of actigraphy data. Transitions in depressive symptoms were based on weekly SCL-90 scores and evaluation interviews. Kernel Change Point analyses were used to detect change points (CPs) and CP timing in circadian rhythm variables for each individual separately.ResultsIn 67% of individuals with depressive symptoms transitions, CPs were identified in proximity to symptom transitions. CPs were detected less frequently in the no-transition group with 7 CPs in 14 individuals, compared to transition groups with 10 CPs in 12 individuals. For several RAR and sleep variables, consistent changes were detected in expected directions.ConclusionsCircadian rhythm variables provide potentially clinically relevant information although their patterns around transitions are highly person-specific. Future research is needed to disentangle which variables are predictive for which patients.DisclosureNo significant relationships.
Duration of therapy and treatment compliance of depressive patients at clinical high-risk for psychosis
Authors: Omelchenko M. 
Published: September 2022

IntroductionIt is known that early withdrawal can lead to a worsening of mental health. This is particularly relevant for depressive patients with clinical high-risk for psychosis (CHR) for whom the recommended duration of treatment has not been established.ObjectivesAnalyze the actual treatment duration of depressive patients at CHR after their discharge from hospital and compare it with the group of depressive patients without CHR.MethodsA comparative study of 124 depressive patients with CHR and 27 depressive patients without CHR was conducted within a year after discharge from hospital to assess the therapy duration and treatment compliance.ResultsWithin a year after discharge only 12.1% depressive patients with CHR and 29.6% ones without CHR continued to receive the therapy. The average duration of treatment after discharge was 7.4 months in the first group and 11.7 months in the second group. The majority of patients stopped treatment for the following reasons (in descending order of importance): lack of awareness of their mental condition (51.9% vs 40.3%), side effects (38.7% vs 11.1%), and negative attitudes towards the treatment on the part of patients’ immediate family members (8.9% vs 7.4%).ConclusionsIt has been found out that depressive patients with CHR are less likely to follow medical prescriptions than ones without CHR, they are more likely to have the lack of awareness of their mental condition, they are more likely to have side effects of the therapy. These findings require the development of a universal approach to the treatment of such patients after discharge from hospital.DisclosureNo significant relationships.
Premorbid screening of healthy students may carry latent liability for schizophrenia or bipolar affective disorder with neurocognitive and neurophenomenological methods
Authors: Szendi Md Habil I. , Bagi A. , Szalóki S. , Hallgató E. , Domján N. , Kanka A. , Gál B. , Karcher É. , Pásztor H. , Jenei T. , Bóna O. , Kovács C. , Pejin A. , Daróczy J. , Diósi Á. , Pajkossy P. , Polner B. , Demeter G. , Racsmány M. , Baradits M. , Búzás A. , Dér A. , Gingl Z. , Gyimóthi T. 
Published: September 2022

IntroductionThis study was carried out to map psychosis spectrum disorder risk factors.ObjectivesOur goal was to find what kind of instrumental methods may help to detect latent liabilities for schizophrenia and bipolar affective disorderMethodsUsing online questionnaires n=710 students were screened. Groups were formed based on the inclusion criteria: N = 25 people prone to mood swings, N = 30 people prone to odd experiences and delusive thinking, and a normal control group with N = 30 people. Personality, temperament, self-experiences, affectivity scales, and cognitive screening were conducted in addition to actigraphy coupled with a mobile application for detecting subjective experiences (EMA). Furthermore, instrumental examination of self-agency, testing time interval discrimination and (re)production, eye-tracking, EEG-microstates, and laboratory testing of inflammatory, immunologic and cardio-metabolic measures of allostatic load were applied.ResultsSelf-experience disorders: both risk groups showed significantly higher scores than the control group (CG). Self-agency: based on incorrectly attributed responses, the positive schizotypy risk factor (PSF) group differed from the CG (p = 0.003). Antisaccade study: the PSF group showed a difference from the CG (p = 0.002). Actigraphy: based on the distributions of diurnal cumulative activities, it distinguished those with a cyclothymic risk factor (CTF) from the CG (67% probability in the k-means clustering procedure).ConclusionsHealthy students with a latent liability for schizotypy or bipolarity could be distinguished by some targeted laboratory methods. Susceptibility for bipolarity was indicated by actigraphic analyzes, and the risk for schizotypal development was indicated by deficiencies in the self-agency experience and by anti-saccadic eye movement disorders.DisclosureNo significant relationships.
Dissemination project: Linking Clinical Practice and Research towards daily function and Mental Health prevention
Authors: Regev S. , Rosenblum S. 
Published: September 2022

IntroductionOccupational therapy (OT) offers evidence-based methods to address daily functioning improvement and better health promotion. However, many adults who are dealing with deficient daily functioning due to unrecognized Attention Deficit Hyperactivity disorder (ADHD) do not benefit from these developed methods. Thus, they are at risk of experiencing adjustment barriers and poor mental health.ObjectivesThe aim of this project is to develop a dissemination strategy in order to reach-out for this unrecognized ADHD population and grasp their attention in an early stage of life. The study following this project is measuring the possibility of this action to reach out to the individuals and make a small change in their daily functional capabilities.MethodsThe Laboratory for the Study of Complex Human Activity and Participation (CHAP) is a lab sited in the occupational therapy department at the University of Haifa. Its research address ADHD as part of further neuro-developmental challenges in the life span. The lab started a dissemination program including 4 OT researchers, and a group of former researchers for materials feedback.ResultsIn the presentation we will share the dissemination strategy and it implementation during 6 months. Moreover, we will present a theoretically map relevant virtual pathways that adults with unrecognized ADHD may cross since childhood.ConclusionsThis preventative program towards health promotion aims to help people achieve meaningful milestones in life and live more fully. Moreover, this strategy may serve as a prototype for similar approaches in other outreach processes.DisclosureNo significant relationships.
Predictive model of the risk of formation of mental deadaptation in chemical production workers
Authors: Kuzmina S. , Garipova R. , Mollaeva N. 
Published: September 2022

IntroductionAccording to WHO, 30-50% of workers experience psychological stress, which contributes to the development of mental and psychosomatic disorders. It’s important to develop the problem of prenosological diagnosis and determination of criteria for the formation of mental maladaptation as predictors of mental disorders in relation to occupational risk factors. Mental disorders in workers in a dangerous environment are of the nature of prenosological, not clearly delineated by a circle of diagnostic symptoms.Objectives1st chemical factor in combination with noise and emotional stress, 2d chemical factor in combination with a threat to life (explosion and fire hazard), 3d working in conditions of noise and emotional stressMethodsThe influence of working environment conditions and non-production factors on the formationResultsPredicting the development of mental mailadaptive state model was developedConclusionsVegetative disorders are most likely to manifest in group 1, comorbid of which with obsessive-phobic disorders and depressive spectrum disorders. The group 2 is characterized by astheno-vegetative symptoms in correlation with the conversion type of response. In the third professional group, the nature of predictors is characterized by a pronounced isolation of groups of symptoms, the leading of which is the vegetative pattern.Vegetative syndroms are most likely to manifest in group 1, comorbid of which is obsessive-phobic disorders and depressive spectrum disorders. The group 2 is characterized by astheno-vegetative symptoms in correlation with the conversion type of response. In the third professional group, the nature of predictors is characterized by a pronounced isolation of groups of symptoms, the leading of which is the vegetative pattern.DisclosureNo significant relationships.
The relationship between parental reflective functioning, attachment style, parental competence, and stress
Authors: Szabó B. , Miklósi M. , Futó J. 
Published: September 2022

IntroductionPrevious studies indicated, that mentalization mediates the link between adult attachment and stress, however, this relationship was not tested before among non-clinical parents of children aged between 12 and 18 years.ObjectivesThe aim of this study was to explore the relationship between parental reflective functioning, attachment style, perceived parental sense of competence, and stress among parents.MethodsAfter providing written consent, 186 non-clinical mothers completed a questionnaire packet that included a demographic form, The Parental Reflective Functioning Questionnaire - Adolescent version, the Attachment Style Questionnaire, the Parental Sense of Competence Scale, and the Perceived Stress Scale. A moderated mediation analysis with parental sense of competence as a dependent variable, mother’s attachment style as an independent variable, certainty about mental states hypermentalization subscale as a mediator, and stress as a moderator was conducted.ResultsIn the moderated mediation analysis, the direct effect of the attachment style on the parental sense of competence in the case of preoccupied attachment style was significant (p < .001). The interaction term of the hypermentalization subscale by perceived stress was also significant in the case of low level (w = -1.57, p < .001) and high level of perceived stress (w= 1.21, p = .049) among mothers with a preoccupied attachment style.ConclusionsThese findings suggest that the preoccupied attachment style is related to the parental sense of competence through certainty about mental states hypermentalization in case of low level and high level of perceived stress, so mentalization-based interventions are warranted.DisclosureNo significant relationships.
Prognostic competence as a criterion for the mental health of primary schoolchildren with psychological development disorders
Authors: Artemyeva T. , Mendelevich V. , Akhmetzyanova A. 
Published: September 2022

IntroductionYounger schoolchildren with psychological development disorders have low cognitive activity, insufficient development of basic school skills, and a low level of educational motivation. In accordance with the requirements of the educational program for students with psychological development disorders, it is important to develop the ability to predict the results of their actions.ObjectivesThe study of predictive competence in primary schoolchildren with psychological development disorders.MethodsThe study involved 60 children aged 8-10 years with a psychological development disorder. To study predictive competence, the methodology “The ability to predict in situations of potential or real violation of social norms” was used.ResultsThe study revealed a low level of the cognitive and speech-communicative spheres of prognostic competence development in primary schoolchildren with psychological development disorders, as well as a deficit in prediction in the field of learning, which includes educational cooperation and educational communication of the child. Generalized statements, a passive position in future situations and pessimistic attitudes prevailed in the predictions of schoolchildren when constructing an image of the future. For schoolchildren with psychological development disorders, the prognosis is presented by monosyllabic answers, with the observable poverty of speech utterances.ConclusionsThe features of prognostic competence revealed in the study make it possible to develop individual programs for the development of the prognostic abilities of schoolchildren with psychological development disorders. This paper has been supported by the Kazan Federal University Strategic Academic Leadership Program.DisclosureNo significant relationships.
ProTransition – evaluation of an online-course for professionals to optimize the health care service for young people with mental illness in transition from adolescence to adulthood
Authors: Koenig E. , Reetz S. , Hoffmann U. , Fegert J.M. 
Published: September 2022

IntroductionAdolescent transitions to adulthood are a vulnerable phase for the development of mental illnesses. Additionally, there are often disruptions in psychiatric care delivery during the transition phase, potentially leading to a considerable treatment delay with a high risk of early chronification. Thus, the health care system and professionals in both child and adolescent psychiatry and adult psychiatry should give greater consideration to the transition phase.ObjectivesAn online-course addressing health care professionals was developed to give in-depth knowledge of “transition psychiatry”, practical guidance and to sensitize for the special challenges and needs of young adults with mental illness. Evaluation focuses on the gain of competences, benefit for practical work and user satisfaction.MethodsParticipants´ estimations and opinions on quality of the online-course, on impact of course participation to their practical work and on their competences regarding transition psychiatry are assessed with an online-survey before starting (t1) and after finishing (t2) the online-course. T1-assessment is already completed with 1924 datasets, t2-assessmend will take place 02/2022.ResultsAnalyses of t1-assessment show a high heterogeneity of participants regarding their work background and setting. Special knowledge about mental illnesses during transition and about transition psychiatry, as well as feeling confident in accompanying transition processes is on a medium level. Results of t2-assessment and comparing analyses are expected in March 2022 and will be presented.ConclusionsThere was high interest of the target group in participating in the online-course. Evaluation will show if the online-course is a helpful measure in delievering the necessary education of professionals in transition psychiatry.DisclosureNo significant relationships.
Association Between Workplace Bullying Occurrence and post-traumatic stress disorder Among Healthcare Professionals in Tunisia
Authors: Mnif M. , Smaoui N. , Omri S. , Feki R. , Gassara I. , Maalej M. , Ben Thabet J. , Zouari L. , Charfi N. , Maalej M. 
Published: September 2022

IntroductionNurses may be particularly at risk of violence exposure at work which can cause psychological trauma and even develop post-traumatic stress disorder (PTSD), which is a serious mental health disorder.ObjectivesThe aim of this study was to determine the prevalence of PTSD among nurses in psychiatry and emergency departments and to identify the factors associated with it.MethodsThis was a cross-sectional, descriptive and analytical study. It concerned 60 nurses working in the psychiatry (35 nurses) and emergency (25 nurses) departments of the Hedi Chaker and Habib Borguiba University Hospital in Sfax. The screening of PTSD was carried out by the « post-traumatic stress evaluation questionnaire » (PTSQ).ResultsDirect trauma exposure was reported by 93% of participants, of which 48.3% experienced the act of violence more than 4 times. According to the PTSQ, 48.3% of the nurses had PTSD with a mean score of 50.93. Hyper-arousal was the most frequently observed outcome in victims (85%), followed by re-experience (83%) and avoidance (80%) symptoms. The presence of PTSD was correlated with female gender (p=0.002), the young age of the nurse (p=0.04), and the absence of peri-traumatic reactions (p=0.001).ConclusionsOur study shows that PTSD is a pathology frequently encountered in psychiatric and emergency nurses. Hence the need to put in place strategies against violence in hospitals and to apply them rigorously in order to better manage this phenomenon and manage its repercussions on health workers .DisclosureNo significant relationships.
Identification of violence in the hospital environment: perceptions of nurses
Authors: Mnif M. , Smaoui N. , Feki R. , Gassara I. , Omri S. , Charfi N. , Ben Thabet J. , Zouari L. , Maalej M. , Maalej M. 
Published: September 2022

IntroductionViolence is recognised by the WHO as a major and ubiquitous public health problem, that is constantly worsening.ObjectivesThe aim of our work was to estimate the frequency of aggressions against nurses in psychiatric and emergency departments, and to identify the factors associated with it.MethodsThis was a cross-sectional, descriptive and analytical study. It took place between January and March 2021, at both hospitals of Sfax (Tunisia).This study targeted 60 nurses in the psychiatry and emergency services.ResultsThe sample comprises 35 nurses (58%) from psychiatric services and 25 nurses (42%) from emergency services, mainly females (51%) and with average age of 35 years.(+/-9). The nurses interviewed were exposed to violence quite often, in 93% of cases. Almost all nurses (90 %) experienced verbal violence, 70 % experienced physical violence and more than half (62 %) experienced psychological violence. Nearly 11% of nurses reported a sexual violence. Factors that explain or contribute to violence mentioned by the participants were as follows; The Verbal violence was significantly correlated with poor reception conditions (p=0.013). The Sexual violence was significantly correlated with young age of nurse (p=0.005). As for psychological violence, it was significantly correlated with work overload (p=0.004), a poor caregiver-patient relationship (p=0.02) and poor patient care (p=0.04).ConclusionsOur study showed that violence against nurses was frequent in psychiatric and emergency departments. Various factors could modulate their occurrence such as training and improvement of the working conditions.DisclosureNo significant relationships.
Immune regulatory gene polymorphisms, frequent cannabis use, and psychosis: implications to Treg hypofunction
Authors: Corsi-Zuelli F. , Loureiro C. , Shuhama R. , Quattrone D. , Deakin B. , Menezes P. , Lacchini R. , Coeli-Lacchini F. , Louzada-Junior P. , Del-Ben C. 
Published: September 2022

IntroductionWe have previously shown that the association between frequent cannabis use and psychosis is more likely in subgroups with low-grade inflammation than subgroups without (PMID: 33736715). The role of immune-related polymorphisms remains unknown.ObjectivesTo explore whether polymorphisms affecting the function of key immune regulatory proteins moderate the association between cannabis and psychosis, namely: ENTPD1 and NT5E, involved in the synthesis of CD39, CD73, respectively, and anti-inflammatory adenosine; CTLA4 and
FOXP1,
essential for Treg functional capacity.MethodsWe genotyped blood samples from 283 community-based controls and 140 recent-onset psychosis patients in Brazil (EU-GEI consortium, Ribeirão Preto/SP) for twelve polymorphisms (ENTPD1: rs3814159, rs3176891, rs10748643; NT5E: rs9444348, rs2295890; CTLA4: rs3087243, rs231775, rs5742909, rs4553808; FOXP1: rs6803008, rs6786408, rs830599; Illumina Human Core Exome-24). Cannabis frequency (daily, less than daily, never) was assessed by self-report (Cannabis Experience Questionnaire). Binary logistic regression models (OR,95%CI) included case status as the outcome, genotype (dominant model), cannabis frequency, and an interaction term between the two as exposure, adjusting for confounders (age, sex, ethnicity, tobacco smoking).ResultsWe found significant interactions between cannabis use and polymorphisms for ENTPD1 (rs3814159), NT5E (rs9444348), and FOXP1 (rs6786408). Less than daily or daily use were, in a dose-response fashion, only associated with psychosis in those with the variant and heterozygous genotypes; less than daily: ENTPD1 AG/GG (3.34,1.71-6.50); NT5E AG/AA (3.71,1.87-7.33); FOXP1 AC/CC (2.98,1.54-5.77); daily: ENTPD1 AG/GG (16.81;5.89-47.96); NT5E AG/AA (21.20,6.81-66.01); FOXP1 AC/CC (13.75,5.22-36.21).ConclusionsVariation in genes that affect Treg function appears to modify the effect of cannabis consumption on psychosis in keeping with Treg hypofunction hypothesis (PMID:33713699).DisclosureNo significant relationships.