bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regular smoking of male ancestors in adolescence and fat mass in young adult grandchildren and great-grandchildren
Authors: Gregory Steven , Suderman Matthew , Northstone Kate , Pembrey Marcus , Watkins Sarah , Iles-Caven Yasmin , Golding Jean 
Published: July 2022

Background: Previous studies using the Avon Longitudinal Study of Parents and Children (ALSPAC) have shown that if men commenced smoking prior to the onset of puberty their sons, their granddaughters and great-granddaughters were more likely to have excess fat (but not lean) mass during childhood, adolescence and early adulthood. In this study we assess associations between ancestral smoking during adolescence (ages 11–16 years) with fat and lean mass of subsequent generations at two ages. Methods: We analysed data on exposures of grandparents and great-grandparents collected by ALSPAC. The outcomes were the fat masses of their grandchildren and great-grandchildren measured at ages 17 and 24. Measures of lean mass were used as controls. Adjustment was made for 8–10 demographic factors using multiple regression. Results: We found associations between adolescent smoking of the paternal grandfathers and the adjusted fat mass of their grandchildren, but no associations with the grandchildren’s lean mass. Grandchildren at age 17 had an average excess fat mass of +1.65 [95% CI +0.04, +3.26] Kg, and at age 24 an average excess of +1.55 [95% CI -0.27, +3.38] Kg. Adolescent smoking by the maternal grandfather showed similar, but weaker, associations: at 17 an average excess fat mass of +1.02 Kg [95% CI -0.20, +2.25] Kg, and at 24 an average excess of +1.28 [95% CI -0.11, +2.66] Kg. There were no pronounced differences between the sexes of the children. For the great-grandparents there were few convincing results, although numbers were small. Conclusions: We have shown associations between grandfathers’ smoking in adolescence and increased fat (but not lean) mass in their children. Confirmation of these associations is required, either in a further data set or by demonstrating the presence of supportive biomarkers.
ROLE OF QUALITATIVE ENDODONTIA IN THE SCHEME OF INTERDISCIPLINARY TREATMENT OF MAXILLARY ODONTOGENIC SINUSITIS
Authors: Marugina Tatyana L. , Levenets Anatolij A. , Kiprin Dmitry V. , Cherevatenko Anna I. 
Published: July 2022

In the treatment of odontogenic maxillary sinusitis, the removal of causative teeth is actively used, although the tooth removal indications are not always clearly defined. Modern endodontic approaches and technologies, in most cases, help preserve the tooth in the oral cavity with the elimination of the chronic infection focus, thus restoring the integrity of the maxillary sinus.
Background. Improve the effectiveness in the treatment of odontogenic maxillary sinusitis while preserving the causative teeth.
Materials and methods. The study involved 50 patients aged 18 to 45 years. All patients had clinical signs of maxillary odontogenic sinusitis and signs of failed endodontic treatment of teeth with a dark, radiolucent focus in the apex region. Radiological parameters and quality of obturation was assessed using CBCT; the presence of symptoms of inflammation was assessed clinically during examination. The results were evaluated after 6, 12 and 24 months. The treatment effectiveness and the quality of obturation was assessed in accordance with the directives of the European Society of Endodontology.
Results. High-quality endodontic treatment resolved clinical signs of odontogenic sinusitis in all patients, restored the bone tissue of the alveolar process and restored the mucous membrane of the maxillary sinus after 12 months in 96% of cases. In 2 cases, additional microsinusotomy was required.
Conclusion. Improving the quality of endodontics in the first treatment or retreatment of the upper jaw teeth can significantly reduce the number of dental extractions in odontogenic maxillary sinusitis
Therapy with vitamin D metabolits of structural and functional changes in bone tissue of working postmenopausal women with ostearcopenia
Authors: Ignatiev O. , Turchin M. , Ermolenko T. , Panyuta O. 
Published: July 2022

The prevalence of osteoporosis and vitamin D deficiency in postmenopausal women working under harmful labour conditions has been examined. Reduced bone mineral density was revealed in 85% of the persons under observation, the incidence of OP was 35%, sarcopenia (SP) - 35%. Vitamin D deficiency was found in 91.3% of the workers, at the same time severe VD deficiency was observed in 32.9%, VD deficiency - in 7.5%, and the optimal level of vitamin D was observed in 1.2% of cases. 79 PM women with OP aged 50 - 60 y. o. (mean age - (55.7 ± 0.9) years), working at harmful conditions of the working environment with an average length of service 26.14 ± 0.91 years have been examined. Clinical group A (n = 30) received cholecalciferol at a dose of 2000 IU (4 drops) per day and alfacalcidol 1 μg (1 capsule) once a day for a year. This resulted in a positive effect on the level of 25(OH)D. The complex appointment of cholecalciferol and alfacalcidol reduced the level of PTH and confirmed the role of VD deficiency in the progress of secondary hyperparathyroidism. The data obtained revealed a slowing of the effect of VD on osteoclastogenesis. Decrease of bone resorption marker CTx in the women under examination confirmed the latter.
The use of physiotherapy methods such as iontophoresis and phontophoresis in the treatment of scars
Authors: Gałuszka Aleksandra 
Published: July 2022

Scars are perceived as marring the body. Sometimes having a scar increases the feeling of shame and difference. There are people who are ashamed of their scars so much that they do not go to the swimming pool, gym or other places where it is necessary to expose the scar. In summer or on warm days, they cover their body to hide the scar. Sometimes, however, people consider having a scar as normal and function as they did before a scar was formed. The situational context of the scar formation is of particular importance, eg a traumatic event, a traffic accident, etc. Then, having a scar may cause psychological consequences in a person and then it is worth seeking help from a psychologist to reconcile with having a scar.
Physiotherapy and cosmetology help people with unacceptable or functional disorders. Thanks to the use of many methods in these areas, it is possible to obtain partial removal of scars or their complete elimination, possibly minimizing the visibility of the lesion.
Estimating Effects of Incentive Contracts in Online Labor Platforms
Authors: Kaynar Nur , Siddiq Auyon 
Published: July 2022

The design of performance-based incentives—commonly used in online labor platforms—can be naturally posed as a moral hazard principal-agent problem. In this setting, a key input to the principal’s optimal contracting problem is the agent’s production function: the dependence of agent output on effort. Although agent production is classically assumed to be known to the principal, this is unlikely to be the case in practice. Motivated by the design of performance-based incentives, we present a method for estimating a principal-agent model from data on incentive contracts and associated outcomes, with a focus on estimating agent production. The proposed estimator is statistically consistent and can be expressed as a mathematical program. To circumvent computational challenges with solving the estimation problem exactly, we approximate it as an integer program, which we solve through a column generation algorithm that uses hypothesis tests to select variables. We show that our approximation scheme and solution technique both preserve the estimator’s consistency and combine to dramatically reduce the computational time required to obtain sound estimates. To demonstrate our method, we conducted an experiment on a crowdwork platform (Amazon Mechanical Turk) by randomly assigning incentive contracts with varying pay rates among a pool of workers completing the same task. We present numerical results illustrating how our estimator combined with experimentation can shed light on the efficacy of performance-based incentives. This paper was accepted by Chung Piaw Teo, optimization. Supplemental Material: The data files and e-companion are available at https://doi.org/10.1287/mnsc.2022.4450 .
Managing Queues with Different Resource Requirements
Authors: Zychlinski Noa , Chan Carri W. , Dong Jing 
Published: July 2022

In many service systems, customers from different classes may have very different resource requirements. These differences include not only the duration of the service but also the units of resource required. This is especially prominent in healthcare settings, where patients with different severity levels can require a different level of medical attention/supervision translating into varying demands of nurse staffing capacity. Motivated by these applications, in “Managing Queues with Different Resource Requirements,” Zychlinski, Chan, and Dong study the optimal scheduling policy of a multiserver queue in which customers from different classes may require different units of servers. When customers have heterogeneous resource requirements, in addition to the cost of waiting and resource requirement, we also need to take policy-induced idleness into account. A good policy needs to carefully balance the myopic cost reduction rate and the more forward-looking system throughput. An index-based policy, referred to as the idle-avoid [Formula: see text] rule, is developed to balance these factors. Theoretical analysis along with numerical experiments provide support for good and robust performance of the proposed policy.
Endogenous Inverse Demand Functions
Authors: Bichuch Maxim , Feinstein Zachary 
Published: July 2022

Endogenous Inverse Demand Functions Buying or selling assets in a financial market impacts the prices upward or downward. Quantifying these price impacts is fundamental to many problems within finance (e.g., optimal liquidation and systemic risk). In “Endogenous Inverse Demand Functions,” Bichuch and Feinstein construct an equilibrium risk sharing problem that results in an endogenous inverse demand function. This is taken in contrast to the often assumed exogenous linear or exponential forms for the inverse demand functions. The authors determine sufficient joint properties for the financial market and assets to replicate these common exogenous forms. The properties of the general endogenous inverse demand functions, found via the equilibrium risk sharing problem, are investigated; the authors deduce that price cross-impacts, which are often assumed to be zero, naturally arise in this equilibrium setting.
Liquid Swine Manure Application Variability: Challenges and Opportunities
Authors: Dougherty Brian W. , Andersen Daniel Steven , Helmers Matthew J. 
Published: July 2022

HighlightsVariability of manure N content on the day of application was a major contributor to plot-to-plot N rate variability.Using the average of previous years’ manure samples is a valid strategy to improve the accuracy of P application.Estimated economic losses from missing target manure N rates averaged $34.27 ha-1 year-1 ($13.87 ac-1 year-1).Improving N rate accuracy with real-time N sensing provided an estimated value of $7 to $44 ha-1 ($3 to $18 ac-1).Abstract. Liquid livestock manure application presents both opportunities for replacing commercial fertilizer and challenges to doing so accurately. This study demonstrated the challenges in achieving a target N application rate using liquid swine manure on eighteen 0.4 ha research plots at the Northeast Research and Demonstration Farm (NERF) near Nashua, Iowa. Differences between the nutrient analyses of manure from a pre-application sample and samples taken on the day of application, equipment adjustments, field conditions, and changing manure nutrient content during pit pumping contributed to variability in the actual N rate applied. The coefficient of variability (CV) of manure N during manure pumping ranged from 2.7 to 13.6, with an 8-year average of 6.5. A weighted-average CV for applied manure volume ranged from 1.5 to 4.7, with an 8-year average CV of 3.2, suggesting that plot-to-plot variability in manure volume was less of an issue for achieving the target N rate than was the variability of manure N on the day of application. A separate analysis of manure from six Iowa swine farms showed that using the average of the previous years’ manure samples improved accuracy for phosphorus at Farm 2, whereas using a single sample from the application year improved accuracy for potassium at Farm 5. Averaged across the six farms, using the average of the previous years’ manure samples resulted in less error for phosphorus than using a single sample from the application year. For nitrogen, there was no significant difference between the two approaches within or across farms (p &lt; 0.1). The average economic loss from missing the target N rate in the NERF study was $34.27 ± $32.49 ha-1 year-1 ($13.87 ± $13.15 ac-1 year-1). The estimated economic value from using real-time nutrient sensing to improve N rate accuracy ranged from $7.56 to $32.03 ha-1 ($3.06 to $12.96 ac-1) in a corn-soybean rotation and from $10.38 to $44.41 ha-1 ($4.20 to $17.97 ac-1) in continuous corn. This study illustrates the need for new technologies for real-time manure nutrient sensing and on-the-go rate adjustment. The economic analysis can serve as a guide for manure applicators when evaluating the feasibility of manure nutrient-sensing systems. Keywords: Manure application, Manure management, Manure nutrient content, Manure nutrient sensing, Manure rate calibration.
Dementia risk and dynamic response to exercise: A non-randomized clinical trial
Authors: Vidoni Eric D. , Morris Jill K. , Palmer Jacqueline A. , Li Yanming , White Dreu , Kueck Paul J. , John Casey S. , Honea Robyn A. , Lepping Rebecca J. , Lee Phil , Mahnken Jonathan D. , Martin Laura E. , Billinger Sandra A. 
Published: July 2022

BackgroundPhysical exercise may support brain health and cognition over the course of typical aging. The goal of this nonrandomized clinical trial was to examine the effect of an acute bout of aerobic exercise on brain blood flow and blood neurotrophic factors associated with exercise response and brain function in older adults with and without possession of the Apolipoprotein epsilon 4 (APOE4) allele, a genetic risk factor for developing Alzheimer’s. We hypothesized that older adult APOE4 carriers would have lower cerebral blood flow regulation and would demonstrate blunted neurotrophic response to exercise compared to noncarriers.MethodsSixty-two older adults (73±5 years old, 41 female [67%]) consented to this prospectively enrolling clinical trial, utilizing a single arm, single visit, experimental design, with post-hoc assessment of difference in outcomes based on APOE4 carriership. All participants completed a single 15-minute bout of moderate-intensity aerobic exercise. The primary outcome measure was change in cortical gray matter cerebral blood flow in cortical gray matter measured by magnetic resonance imaging (MRI) arterial spin labeling (ASL), defined as the total perfusion (area under the curve, AUC) following exercise. Secondary outcomes were changes in blood neurotrophin concentrations of insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and brain derived neurotrophic factor (BDNF).ResultsGenotyping failed in one individual (n = 23 APOE4 carriers and n = 38 APOE4 non-carriers) and two participants could not complete primary outcome testing. Cerebral blood flow AUC increased immediately following exercise, regardless of APOE4 carrier status. In an exploratory regional analyses, we found that cerebral blood flow increased in hippocampal brain regions, while showing no change in cerebellum across both groups. Among high inter-individual variability, there were no significant changes in any of the 3 neurotrophic factors for either group immediately following exercise.ConclusionsOur findings show that both APOE4 carriers and non-carriers show similar effects of exercise-induced increases in cerebral blood flow and neurotrophic response to acute aerobic exercise. Our results provide further evidence that acute exercise-induced increases in cerebral blood flow may be regional specific, and that exercise-induced neurotrophin release may show a differential effect in the aging cardiovascular system. Results from this study provide an initial characterization of the acute brain blood flow and neurotrophin responses to a bout of exercise in older adults with and without this known risk allele for cardiovascular disease and Alzheimer’s disease.Trial registrationDementia Risk and Dynamic Response to Exercise (DYNAMIC); Identifier:NCT04009629.
The gene knockout of angiotensin II type 1a receptor improves high-fat diet-induced obesity in rat via promoting adipose lipolysis
Authors: Li Aiyun , Shi Wenjuan , Wang Jin , Wang Xuejiao , Zhang Yan , Lei Zhandong , Jiao Xiang-Ying 
Published: July 2022

Aims
The renin-angiotensin system (RAS) is over-activated and the serum angiotensin II (Ang II) level increased in obese patients, while their correlations were incompletely understood. This study aims to explore the role of Ang II in diet-induced obesity by focusing on adipose lipid anabolism and catabolism.

Methods
Rat model of AT1aR gene knockout were established to investigate the special role of Ang II on adipose lipid metabolism. Wild-type (WT) and AT1aR gene knockout (AT1aR-/-) SD rats were fed with normal diet or high-fat diet for 12 weeks. Adipose morphology and adipose lipid synthesis and lipolysis were examined.

Results
AT1aR deficiency activated lipolysis-related enzymes and increased the levels of NEFAs and glycerol released from adipose tissue in high-fat diet rats, while did not affect triglycerides synthesis. Besides, AT1aR knockout promoted energy expenditure and fatty acids oxidation in adipose tissue. cAMP levels and PKA phosphorylation in the adipose tissue were significantly increased in AT1aR-/- rats fed with high-fat. Activated PKA could promote adipose lipolysis and thus improved adipose histomorphology and insulin sensitivity in high-fat diet rats.

Conclusions
AT1aR deficiency alleviated adipocyte hypertrophy in high-fat diet rats by promoting adipose lipolysis probably via cAMP/PKA pathway, and thereby delayed the onset of obesity and related metabolic diseases.
A randomised controlled trial to test the effects of fish aggregating devices (FADs) and SBC activities promoting fish consumption in Timor-Leste: A study protocol
Authors: Tilley Alexander , Byrd Kendra A. , Pincus Lauren , Klumpyan Katherine , Dobson Katherine , dos Reis Lopes Joctan , Shikuku Kelvin Mashisia 
Published: July 2022

Timor-Leste is one of the world’s most malnourished nations where micronutrient-deficient diets are a contributing factor to the prevalence of child stunting, currently estimated to be 45.6% of children under five. Fish are an important source of nutrients and one that may assist the country’s predominantly rural population of agriculturalists to exit poverty and malnutrition. However, a small national fishing fleet producing low catch volumes places fish out of reach of most inland and upland populations where it is needed most. Fish consumption is very low in rural, inland areas compared to coastal, regional, and global averages. This study is a one-year, partially masked, cluster-randomized controlled trial among families living in rural, inland Timor-Leste. We aim to test and compare the effects of two treatments, alone and in combination, on the frequency and volume of household fish consumption in rural, inland areas as a proxy for improved dietary diversity and micronutrient intake. Treatment 1 is the installation of nearshore, moored fish aggregating devices (FADs) to improve catch rates with existing fishing gears. Treatment 2 is a social and behaviour change (SBC) activity to promote fish consumption. Villages in inland communities will be randomized to receive treatment 1, treatment 2, both treatments, or neither treatment. Data will be collected at baseline (prior to the rollout of the treatments) and endline. Our study will determine the impact of an improved supply of fish, along with nutrition-oriented SBC activities, on the fish purchasing and consumption practices of rural, inland households. Findings from this study are urgently needed by Small Island Developing States to guide policy and investment decisions on how best to improve households’ diets using locally available, nutrient-dense foods such as fish. Investments such as these are needed to break the cycle of malnutrition. This trial is registered at clinicaltrials.gov (NCT04729829).
Trial registration: Trial registered at clinicaltrials.gov Identifier: NCT04729829.
The association between Alu hypomethylation and the severity of hypertension
Authors: Thongsroy Jirapan , Mutirangura Apiwat 
Published: July 2022

Introduction
Epigenetic changes that cause genomic instability may be the basis of pathogenic processes of age-associated noncommunicable diseases (NCDs). Essential hypertension is one of the most common NCDs. Alu hypomethylation is an epigenetic event that is commonly found in elderly individuals. Epigenomic alterations are also found in age-associated NCDs such as osteoporosis and diabetes mellitus. Alu methylation prevents DNA from being damaged. Therefore, Alu hypomethylated DNA accumulates DNA damage and, as a result, causes organ function deterioration. Here, we report that Alu hypomethylation is a biomarker for essential hypertension.

Results
We investigated Alu methylation levels in white blood cells from normal controls, patients with prehypertension, and patients with hypertension. The hypertension group possessed the lowest Alu methylation level when classified by systolic blood pressure and diastolic blood pressure (P = 0.0002 and P = 0.0088, respectively). In the hypertension group, a higher diastolic blood pressure and a lower Alu methylation level were observed (r = -0.6278). Moreover, we found that changes in Alu hypomethylation in the four years of follow-up in the same person were directly correlated with increased diastolic blood pressure.

Conclusions
Similar to other age-associated NCDs, Alu hypomethylation is found in essential hypertension and is directly correlated with severity, particularly with diastolic blood pressure. Therefore, Alu hypomethylation may be linked with the molecular pathogenesis of high blood pressure and can be used for monitoring the clinical outcome of this disease.