bluuebunny/crossref_metadata_2025_split huggingface dataset:
¿Reducen las estatinas el riesgo de glaucoma? revisión de las evidencias
Authors: Alvarez de Sotomayor Maria , Pastor Laura 
Published: March 2022

Introducción: Los objetivos de este trabajo son revisar y resumir los datos publicados hasta el momento que relacionen el uso de estatinas con el riesgo de aparición o de agravamiento de glaucoma y plantear una hipótesis que explique los efectos protectores de las estatinas y su asociación con un menor riesgo de glaucoma.
Método: se realizó una revisión en PubMed usando los términos “statins, hmg coa” o “hmg coa inhibitors” y “glaucoma” o “open angle glaucoma” o “intraocular pressure”. Se seleccionaron todos los artículos que incluían estudios clínicos o meta-análisis y se excluyeron comentarios, cartas a editor, artículos retractados e investigación en modelos animales. Todos los artículos fueron posteriores a 2004. Se emplearon en la revisión 17 artículos.
Resultados: la mayor parte de los estudios muestran un efecto protector de las estatinas frente a la aparición y agravamiento del glaucoma de ángulo abierto. Sin embargo, otros estudios no llegan a encontrar una relación significativa e incluso alguno muestra una relación entre el glaucoma y el empleo de estatinas a altas dosis. Los efectos neuroprotectores y la inhibición de la Rho-quinasa podrían explicar los efectos encontrados.
Conclusiones: la evidencia publicada no es suficiente como para recomendar el tratamiento con estatinas con el objetivo de prevenir el avance o la aparición del glaucoma.
Consecuencias derivadas de la automedicación con benzodiacepinas en personas adultas: revisión exploratoria
Authors: Sanz-Valero Javier , Cantos-Azorín Cristina 
Published: March 2022

Introducción: Revisar la evidencia científica sobre las consecuencias derivadas de la automedicación con benzodiacepinas (BZD) en personas adultas.
Método: Revisión exploratoria de los artículos recuperados de las bases de datos MEDLINE (PubMed), Embase, Cochrane Library, Scopus y Web of Science hasta octubre de 2020. La búsqueda se formuló́ mediante los descriptores “Self Medication” y “Benzodiazepines”, utilizando los Entry Terms relacionados y los filtros: «Humans» y «Adult: 19+years». La calidad de los artículos se evaluó́ mediante STROBE.
Resultados: De las 388 referencias recuperadas, tras aplicar los criterios de inclusión y exclusión, se seleccionaron 14 artículos. Las puntuaciones STROBE oscilaron entre mínimo de 8,7 y máximo de 17,7, con mediana de 14,3. En 8 artículos se estudió la automedicación; en 2 el abuso; en otros 2 la automedicación o el abuso con la finalidad de tratar las emociones, el estrés o, directamente, drogarse. Otros resultados fueron la sobredosificación y el consumo previo y posterior de BZD al ingreso en programa de metadona.
Conclusiones: Los artículos revisados reportaron elevada prevalencia de automedicación y auto-manipulación de BZD. Es necesario conocer el patrón de uso en cada grupo poblacional para establecer medidas que garanticen una adecuada prescripción y uso racional. Mejorando la atención farmacéutica en el proceso de dispensación de BZD (alertando sobre las consecuencias de un tratamiento crónico y la exclusividad de las recetas) y la validación farmacéutica (detección de prescripciones inadecuadas), se podría actuar contra la automedicación de las BZD y las consecuencias derivadas.
Idoneidad de la monitorización de niveles de ácido valproico en un hospital infantil en México
Authors: Robles-Piedras Ana Luisa , Hernández-Jerónimo María Del Rosario , Chehue-Romero Alejandro , Olvera-Hernández Elena Guadalupe 
Published: March 2022

Introducción: en México, la cuantificación de fármacos en plasma se utiliza para comprobar la toxicidad, el cumplimiento y la titulación de dosis en el tratamiento con fármacos anticonvulsivos como el ácido valproico (AVP), pero sin considerar los principios de farmacocinética debido a la ausencia de farmacéuticos clínicos en el Sistema de Salud.
Método: el presente estudio es un análisis retrospectivo que incluye los datos de concentración plasmática de ácido valproico en pacientes pediátricos de 1 a 15 años de edad, con diagnóstico confiable de epilepsia.
Resultados: se revisaron los archivos de 260 pacientes, se encontró que solo el 56,5% de los pacientes tenían niveles séricos en estado estacionario. Los niveles plasmáticos de AVP se encontraron a nivel subterapéutico en el 22% de los pacientes y el 15% tenían niveles tóxicos. El análisis muestra que los niños menores de cinco años aparecen como un grupo heterogéneo para las variables estudiadas.
Conclusiones: debido a la falta de reconocimiento de los farmacéuticos clínicos en México, recomendamos que el mejor resultado clínico se evalúe mediante el monitoreo de los parámetros farmacocinéticos y no solo mediante la dosificación de prueba y error.
Skeletal muscle relaxant activity of different formulation of span 60 niosomes
Authors: Keservani Raj K. , Gautam Surya Prakash 
Published: March 2022

Introduction: Spasticity is a disease of motor neurons that manifests as accelerated muscle tone and stiffness. The niosomes can be formulated with the aid of proper adjustment of process parameters to enhance baclofen entrapment and sustaining the drug release.
Method: The main purpose of this study is to compare different formulations of span 60 niosomes containing baclofen for skeletal muscle relaxant activity on mice (Swiss albino mice) by rota rod method.
Results: The particle size of formulated niosomes was in the range of 3.62±0.54-4.08±0.64 µm and these were smooth, circular fit and generally small multilamellar. Entrapment efficiency of optimized formulation was 88.44±0.28 %. The most extreme % cumulative drug release was 87.88±8.66% after 10 h. The formulation stored at 4±2 °C temperature shows better stability (96.65±0.45) contrasted with raised temperature. Swiss albino mice were utilized for in vivo study and displayed improved muscle relaxant action as far as no. of tumbles from rota rod apparatus (p value =0.001) are concerned.
Conclusions: Nonetheless, diazepam treated mice were observed to have higher muscle relaxation than any dose of formulation tested. The formulation F9 shows better skeletal muscle relaxant activity as compared to F6, F7, F8 and F10 on mice (Swiss albino mice) by the rota rod technique.
Calligraphic Design in Fractal Model Based on Rectangle Collage Decomposition
Authors: Darmanto Tedjo 
Published: March 2022

A fractal model can deliver the beauty of self-similarity feature to be used in designing artistic things such as calligraphic characters. The fractal model can deliver the power of mathematics to be used in modeling the complex things that can be handled by computer programs. This paper delivers the short-cut way to design the artistic calligraphic characters based on the modification of the existing form of the simple rectangle fractal object to construct the stroke form of the calligraphic character as the simple solution of the inverse problem. The upright collage component design of rectangle fractal object can be decomposed into many cells of collage component of a calligraphic character with equal size in the right position of the cells according to the stroke of calligraphic character designed. The short-cut way to encode the fractal object is by copy-editing the representative IFS code based on the position of the cells according to the position of each component of the stroke. The calligraphic characters in fractal form as the collection of IFS code set are the representation of the affine coefficient functions, so they can be easily modified by means of the affine transformation function to any desired form.
Performing for Social Justice: Efficacy of Political Theatre in Nepal and the Philippines
Authors: Lamsal Jiva Nath 
Published: March 2022

Theatre plays a vital role in the struggle for democracy, functioning as an alternative medium for presenting social problems “of and to” the people and proving its efficacy as a powerful creative force in unravelling the hidden truths of repressive regimes. This article examines and compares the role of theatre in a Nepali and Filipino context, in particular its deployment in response to repressive regimes, and argues that theatre is both adaptable and efficacious as a tool for social and political justice. Although never colonised, Nepal was under the control of the Rana Oligarchy for over one hundred years (1846-1951). This period of oligarchical rule was followed by three decades of totalitarianism under King Mahendra’s party-less Panchayat system (1960-1990). Despite and because of this climate of political brutality and oppression, theatre and performance traditions endured. These traditions made “the invisible visible,” serving to awaken the population to their democratic rights. In the Philippines, theatre and performance traditions have been used to push back against centuries of foreign influence. More recently, these traditions have been deployed in response to the authoritarian rule of President Rodrigo Roa Duterte, in particular his aggressive war on drugs. As this study shows, theatre has been a powerful means to fight against autocratic polity and restoration of democracy in Nepal and colonial forces as well as dictatorship in the Philippines.
Soft Power, Crisis of Existence and the Tribal People of Kerala:A Study of Mother Forest, the Unfinished Story of C. K. Janu
Authors: Das Shruti 
Published: March 2022

Joseph Nye coined the term “soft power” which he says means “getting others to want the outcomes that you want.” The world’s largest democracy India is also the home of millions of impoverished people including many indigenous tribes that are impediments to the desired rapid economic and political growth of India. Mother Forest: The Unfinished Story of C. K. Janu, written by Janu Bhaskaran and translated from the original Malayalam into English by N. Ravi Shanker, narrates the story of the struggle of the Adiyas, a tribal people of Kerala, whose identity and livelihood is threatened when they are dispossessed of their ancient land in the forest. The tribe is led by Janu, a girl from their community, whose struggles against the soft power of the State inform the crisis of existence of these tribal people. This paper will attempt to study the crisis of existence of the tribal people in the narrative of Mother Forest using Nye’s theory of “soft power”. This paper will attempt to expose the authoritarianism of State policies vis a vis the helplessness of the indigenous people in the face of displacement from their original habitat as described in Mother Forest.
HUMAN IDENTIFICATION SYSTEM BASED ON BRAINPRINT USING MACHINE LEARNING ALGORITHMS
Authors: A. Ali Bushra , H. Ali Ekbal 
Published: March 2022

In the medical field, due to the development of neuroimaging, several new methods of the biometric field have been attending and favorable candidates for the identification of people. These methods are part of "covert biometrics" that involve the use of measures of clinical and medical images to identify them. The prime motivation to use an invisible (Hidden biometric) is the fact that attacks of a system can be very hard to deal with. This privacy strongly contributes to the increased strongest in the topic of person's verification and identification. In this article, he extracted a brain signature, called a "brain fingerprint" from brain (MRI) Magnetic Resonance Image, obtained from 30 healthy subjects as images (1739), these real data sets from Yarmok Medical Hospital. These brainprint in this work are considered to be a hallmark of the brain. The objective of this proposed work which is design a robust, accurate human identification using human brain print, the brain classification based on several phases, included Data acquisition, Feature extraction processing depend on linear discrimination analysis (LDA) to gain important and interesting features of every image calculated by (number of features in the class). The proposed system shows rise detection precision with the features extracted based on LDA with automatical classifier learning by K nearest neighbor (K-NN) and logistic regression (LR) from the LDA method gained with the LR algorithm of (93%) while LDA method gained (91%) with K-NN.
SHEAR BEHAVIOR OF FIBROUS REINFORCED CONCRETE WIDE BEAMS
Authors: T. Abduljabar Hasan , Fadhil Abbas Ra'id 
Published: March 2022

When a reinforced concrete beam does not have enough shear strength and / or little amount of secondary rebar are reinforced, the "shear failure" is possible. Such type of failure is not acceptable in civil engineering due it does not indicate any prior notice before the complete failure of the intended structural member. One of the most popular solutions to overcome such shortcoming is the addition of steel fibers due to the ability for enhancing mechanical properties and ductility. Wide beams are such beams that have high width if compared with its thickness, such structural members are frequent in many reinforced concrete building systems and may also face "shear failure" during its service life. The current study investigates the structural behavior of the Steel Fiber Reinforced Concrete Wide Beams by proposing an experimental program comprising casting and testing of twenty beams specimen. The effective shear spans to depth ratio ratios were 2.5 and 3.5, respectively. Two nominal strength levels 30 MPa "Normal strength concrete" and 60 MPa "High strength concrete are also included. The types of steel fibers used are the "End Hocked" as well as the "Staggered" in 0.5% and 1.5% volume fractions for each one. The results showed that the addition of steel fibers enhances the consequent mechanical properties and the relevant structural behavior of wide beams to a serious concern. Furthermore, the addition of steel fibers modified the shear failure mode to "flexural". The first cracking load increased in "Normal strength" from 21.95% to 73.73% by adding "End Hocked" and from 12.19% to 45.45% by adding "Staggered" while such range reported 15.95% to 45.76% for "End Hocked" and 7.25% to 28.81% for "Staggered" in "High strength". Additionally, the ultimate load increased in "Normal strength" from 19.75% to 65.98% by adding "End Hocked" and from 10.52% to 43.81% by adding "Staggered" while such range reported 13.5% to43.57 % for "End Hocked" and 7.25% 29.29to % for "Staggered" in "High strength".
PENDIDIKAN KEWARGANEGARAAN SEBAGAI UPAYA PERTAHANAN IDENTITAS NASIONAL DALAM PENDIDIKAN MULTIKULTURAL
Authors: Edi Agus Sarwo 
Published: March 2022

AbstrakKarya tulis ini mengkaji ilmu dengan metode kualitatif dengan teknik pengumpulan data in-depth-interview yang bertujuan memberikan wawasan tentang penguatan identitas nasional melalui pendidikan multikultural. Dewasa ini, era globalisasi pada saat ini menyebabkan arus informasi dan mobilitas manusia dari satu daerah ke daerah lain bergerak dengan cepat. Hal ini memungkinkan interaksi manusia antara satu bangsa dengan bangsa lainnya menjadi semakin intens. Salah satu akibat yang ditimbulkan dari adanya globalisasi ini adalah adanya pengaruh yang sangat kuat dari nilai-nilai dan budaya luar yang mempengaruhi kehidupan masyarakat, terutama generasi muda. Diantara nilai dan budaya yang diserap masyarakat, banyak yang tidak sejalan dengan nilai-nilai Pancasila, sehingga dikhawatirkan hal ini berdampak pada tergerusnya nilai-nilai nasionalisme dan identitas bangsaKata kunci: Identitas nasional, globalisasi, pendidikan multikultural AbstractThis paper examines science using qualitative methods with in-depth-interview data collection techniques aimed at providing insight into strengthening national identity through multicultural education. Today, the current era of globalization causes the flow of information and human mobility from one area to another to move quickly. This allows human interaction between one nation and another to become more intense. One of the consequences of this globalization is the very strong influence of foreign values and cultures that affect people's lives, especially the younger generation. Among the values and cultures that are absorbed by the community, many are not in line with the values of Pancasila, so it is feared that this will have an impact on the erosion of the values of nationalism and national identity..Keywords: National identity, globalization, multicultural education
PEMIKIRAN SOEKARNO DALAM AJARAN MARHAENISME
Authors: Raeinady Vhiasyah , Dewantara Jagad Aditya 
Published: March 2022

AbstrakTulisan ini menjelaskan sebuah konsep dari pemikiran Soekarno mengenai Marhaenisme yang dianalis dan dibedah sesuai dengan sumber kepustakaan yang ada. Kemudian, berisi sebuah wacana terhadap Indonesia tentang kewajiban pemerintah melindungi kaum Marhaen di tengah pandemi covid-19. Marhaenisme identik sebuah ideologi perjuangan yang melawan kapitalisme yang tumbuh dan berkembang di dunia ini. Marhaenisme lahir dan tumbuh berdasarkan rasa senasib dan sepenanggungan yang diakibatkan oleh kolonialisme dan imperialisme. Akibat penjajahan yang dilakukan oleh bangsa asing membuat rakyat Indonesia hidup dalam penuh penderitaan dan kesengsaraan. Dengan adanya ideologi ini diharapkan Indonesia yang terjajah segera bangkit dan pulih kembali. Kemudian, mampu mengelola kekayaan negeri sendiri tanpa tunduk kepada orang lain. Marhaenisme berusaha menghapus segala bentuk pertentangan dan perbedaan dalam kehidupan. Dalam hal ini, ideologi tersebut berusaha menjadi pembeda dengan ideologi lainnya.Kata kunci: Soekarno, Marhaenisme, Ideologi AbstractThis paper describes a concept from Soekarno's thoughts on marhaenism which is analyzed and dissected according to the available literature sources. Then it contains a discourse against Indonesia about the government's obligation to protect the Marhaen in the midst of the covid-19 pandemic. Marhaenism is identical to an ideology of struggle against capitalism that grows and develops in this world. Marhaenism was born and grew based on a sense of shared destiny and shared responsibility caused by colonialism and imperialism. As a result of colonization by foreign nations, the Indonesian people live in full of suffering and misery. With this ideology, it is hoped that colonized Indonesia will soon rise and recover. Then, they are able to manage the wealth of their own country without submitting to others. Marhaenism tries to erase all forms of contradictions and differences in life. In this case, ideology is made trying to be different from other ideologies.Keywords: Soekarno, Marhaenism, Ideology
Effect of Silibinin in Lowering the Intraocular Pressure in Normotensive Rabbits: Interaction with Betaxolol
Authors: A. Hussain Saad , M. Mohammed Haider , H. Jwaied Ahmed , H. Abdulrazzaq Munaf 
Published: March 2022

Previous reports demonstrated the effectiveness of silibinin hemisuccinate as a potential intraocular pressure-lowering agent. The exact mechanism by which silibinin exerted this effect has not yet been documented, but might suggested to interfere with aqueous humor formation. The present study was designed to evaluate the comparative efficacy of silibinin as IOP lowering agent to that of betaxolol in normotensive rabbits, and the interaction of silibinin with betaxolol as a way for investigating the possible mechanism of action of silibinin in this respect. The effects of instillation of 0.75% silibinin solution and 0.5% betaxolol eye drops in the eyes of normotensive rabbits were evaluated using indentation tonometry. The results showed that 0.75% solution of silibinin was more potent than betaxolol (0.5%) in lowering IOP in normotensive rabbits. Furthermore, the effect of pre- and post-instillation of silibinin-betaxolol combination showed a characteristic antagonistic feature. In conclusion, silibinin appears to be more potent than betaxolol in lowering IOP in normotensive rabbits; the pre- and post-instillation of silibinin provide experimental evidence for the possible antagonistic effect of betaxolol with the IOP-lowering effect of silibinin.
Key words: silibinin, betaxolol, cAMP, PDE-inhibitors
STRATEGI PENGEMBANGAN BADAN USAHA MILIK NAGARI (BUMNAG) DI NAGARI JAHO KECAMATAN X KOTO MENGGUNAKAN ANALISIS SWOT
Authors: Rahim Febria , Nufus Nurul Hayatun 
Published: March 2022

Permasalahan dalam penelitian ini adalah BUMNag di Nagari Jaho sudah terbentuk danpemerintah pusat memberikan dana awal sebesar Rp.200.000.000,00 (dua ratus juta rupiah) pada tahun 2017 yang disetorkan langsung ke rekening pengurus BUMNag untuk dikelola berdasarkan potensi yang dimiliki nagari.Nagari Jaho sendiri memiliki potensi usaha yang dapat dikembangkan dalam berbagai sektor seperti sektor pertanian, peternakan, jasa, dan produksi, saat ini BUMNag di Nagari Jaho sudah memiliki usaha dalam bidang peternakan yaitu pengemukan sapi pedaging, ternak kerbau dan ternak ikan serta dalam bidang jasa yaitu sewa tenda dan sound system, namun usaha tersebut belum berjalan sesuai target dari BUMNag.Oleh karena itu bagaimana strategi yang dilakukan Badan Usaha Milik Nagari (BUMNag) di Nagari Jaho untuk mengembangkan usahanya dalam meningkatkan pengelolaan potensi nagari dan meningkatkan perekonomian nagari. Tujuan penelitian ini adalah untuk menganalisis strategi pengembangan usahamenggunakan analisis SWOT dengan strategi SO (Strengths dan Opportunities), strategi WO (Weaknesses dan Opportunities), strategi ST (Strenghts dan Threats) dan strategi WT (Weaknesses dan Threats)pada Badan Usaha Milik Nagari (BUMNag) di Nagari Jaho. Penelitian ini dilakukan dengan metode deskriptif kualitatif dengan teknik pengumpulan data melalui wawancara dan dokumentasi. Selanjutnya untuk pengolahan data yang terkumpul penulis melakukan klasifikasi terhadap aspek permasalahan dan kemudian memaparkan melalui kalimat yang efektif. Hasil penelitian ini menunjukkan bahwa strategi yang digunakan untuk mengembangkan usaha pada Badan Usaha Milik Nagari (BUMNag) Talago Kumbang Nagari Jaho adalah strategi SO (Strength dan Opportunities) mengelola Sumber Daya Alam (SDA) yang berlimpah dengan memberdayakan Sumber Daya Manusia (SDM) yang memadai, pengelolaan dana secara efektif dan efesien dengan memanfaatkan profesi masyarakat yang sebagian besar adalah petani dan peternak, pengurus BUMNag mengelola usaha sesuai prinsip syariah dilatarbelakangi dengan masyarakat nagari yang 100% muslim dan BUMNag membuat program usaha yang tidak dijalankan pihak lain/minim persaingan dan sesuai dengan potensi desa.
Pengaruh Kinerja Dokter Gigi Terhadap Mutu Pelayanan dan Implikasinya Pada Kepuasan Pasien
Authors: Hidayah Nurul , Muhardi Muhardi , Suwarsih Sri 
Published: March 2022

Clinics and hospitals as public health care service s have to be able to maximize the available resources, namely dentists. The high number of oral health problems in Indonesia requires better dentist performance. This study aims to determine the performance of dentists, the quality of dental treatment services, patient satisfaction, and the effect of dentist performance on service quality and its implications for BPJS patient satisfaction at the primary clinic in Bandung. The study used pathway analysis methods to test the effect of intervening variables on dependent and independent variables This study involved 100 BPJS patients at the primary dental clinic from 28 sub-districts in Bandung City as samples. The results of the study showed that respondent’s perception of dentist performance variables indicated that dentists had a fairly good performance in providing health care services to BPJS patients at primary clinics. Respondent’s perception of service quality variables shows that dentists provide a fairly good service quality to BPJS patients at primary clinics. Respondent’s perception of the satisfaction variable showed that BPJS patients aere satisfied with health care services at primary clinic. It can be concluded that the dentist performance variable through service quality has a significant influence on patient satisfaction.