bluuebunny/crossref_metadata_2025_split huggingface dataset:
How to Grasp the Key Links of PBL Teaching Reform in iOS Curriculum System
Authors: Lu Ming , Liu Yixian 
Published: July 2022

The School of Software of Northeastern University actively promotes PBL classroom teaching reform, which requires
that classroom teaching content can not only enable students to fully understand and master the mainstream cutting-edge science
and technology in today’s market, but also that the whole classroom teaching process can fully stimulate students’ interest in
learning and improve their active learning ability, better guide students to expand their knowledge outside the curriculum, and
improve their overall professional comprehensive quality. Firstly, this paper analyzes the outstanding problems in the current
classroom teaching that affect students’ learning effect and can’t improve students’ hands-on ability, and thinks about the concrete
practical thinking of implementing PBL teaching reform in the key links of iOS curriculum system. Combined with the actual
situation of undergraduate teaching in Software College of Northeastern University, it puts forward ways and methods to solve
many problems, including introducing massive open online course resources. Finally, the paper discusses the teaching reform and
its effect of an undergraduate course-”iOS Development Technology”, which the author has undertaken, proves that the proposed
reform measures are effective, and makes some prospects for the future teaching improvement.
The Development of Pointing Gestures in Children
Authors: Chen Zisheng 
Published: July 2022

Pointing is seen as the cornerstone of human communication, and many researches have provided evidences for the fact
that human infant start to point before they can speak. However, these studies have often focused on the motivation and function
behind their pointing behaviors. This study investigated children pointing gesture development by administering a referential communication task. Our findings showed that children from five to six do much better than other children as they can successfully use
manual pointing to complete the task on the basis of understanding the task requirements.
Reforming the Teaching Methods of International Marketing Courses in the Context of Belt and Road
Authors: Zhai Shanshan 
Published: July 2022

International Marketing is a professional course for Economics major. The teaching of this course can help students
master the basic knowledge of modern international marketing courses, develop students’ marketing skills, so that they can plan
international marketing activities, and make decisions on products, pricing and distribution in international markets, marketing and
decision-making; at the same time, improve students’ ability to analyze and solve international marketing-related problems. In the
new era, combined with the national “One Belt, One Road” strategy and the strategic layout and promotion of the “National Brand
Plan”, Chinese enterprises have become scarce international talents, international marketing talents are an important part of the
internationalization of talents, and promoting the reform of international marketing training curriculum has become an important
way to improve and train international marketing talents. This paper discusses in detail this paper on the basis of the analysis of
the international marketing course teaching plan and practice reform, systematically analyze the classroom teaching effect and
the main problems, and finally put forward targeted measures and suggestions to improve the teaching reform effect, to provide
reference for further teaching reform and practice teaching methods.
Enterprise Financial Risk Control
Authors: Li Hong 
Published: July 2022

In recent years, my country’s enterprises have developed rapidly and have become an important force in my country’s
national economic and social development. However, many star companies have only been in decline for 10 years. Among the
reasons for the decline of these companies, the poor control of corporate financial risks is one of the most important factors. Since
the financial risks faced by the enterprise are closely related to the sustainable survival and healthy development of the enterprise, it
is necessary to carefully study the subjective and objective causes of financial risks, and explore a set of effective risk management
strategies, which are of great significance to the sustainable survival and healthy development of the enterprise. special meaning.
Research on the Problems and Countermeasures in the Review of Constitutionality about Normative Documents in China
Authors: Ma Yuzheng 
Published: July 2022

There are still some problems hindering the development of the "constitutionality review" system. First, whether
the objects of the constitutionality review include laws enacted by the National People's Congress and its Standing Committee
(NPCSC);Second, when reviewing normative documents, legality review is often superior to constitutionality review. Third, the
single use of "Internal communication mode" to deal with the consequences of constitutional review will hinder the implementation
of constitutional responsibility. In view of the above problems, the analysis and countermeasures should be suggested:first, the
laws enacted by the NPCSC are not within the scope of constitutional review and must be cleared; Secondly, the establishment of
the standard of "constitutionality review" is helpful to make the constitutionality review superior to the legality review in specific
cases.[1] Finally, reference constitutional cases should be developed to help review authorities strictly enforce unconstitutional
responsibilities, rather than just using "internal communication models".
Inheritance of Shandong Zheng in Shenyang Conservatory of Music
Authors: Wei Wei 
Published: July 2022

In this article, the Shandong tradition Zheng art the main way of art form, melody structure, performance, playing techniques and so on has carried on the simple demonstration, and famous Yun-Juan Zheng master Zhao Yuzhai’s representative works
to illustrate the new development of Zheng art in the 20th century in Shandong, as a folk to professional colleges and universities
teaching master of art, Mr. Zhao Yuzhai not only brought folk music into professional art colleges, but also cultivated a large number of outstanding artistic talents in Shenyang Conservatory of Music. Among them, artists represented by Mr. Gao Liang continue
to develop and innovate Shandong Zheng music art. This article uses the classical Shandong music piece “Ying Zhuan Huang Li”
and its variations to explain how Shandong Zheng music art adapts to the needs of the society in the new period, and continues to
inherit and develop the method, which is worth learning.
How to Cultivate Pupils’ Attention Quality by Using Activity Class
Authors: Wu Haifeng 
Published: July 2022

Attention is a positive psychological activity. It is a golden key to open the door of wisdom. Without attention, there
would be no understanding of things. It is a sufficient and necessary condition for all psychological activities. With attention,
students can keep their feelings, perception,imagination,thinking,memory and other intellectual activities in the learning process,
and they can concentrate on learning. Therefore,cultivating students’ attention quality is an important psychological factor to make
learning effective. Mental health education activity class is a kind of education and teaching form quietly rising in the process of
quality education. Compared with many forms of mental health education, it has the characteristics of various forms, strong interest,
active classroom atmosphere and new teaching ideas. Then, how to use activity class to cultivate the attention quality of primary
school students? The author summarizes the following methods through teaching practice:1.Determine the activity organization
form according to the students’ psychology of “seeking novelty” and “seeking difference”.2.Select the training content based on
students’ life experience.3.Take some simple self-test methods to stimulate students’ desire for training.4.Extend extracurricular
activities and apply them practically.
The Power of Teaching Strategy and its Impact on Children with ADHD
Authors: Feng Chencheng 
Published: July 2022

Attention deficit hyperactivity disorder (ADHD) is a type of disorder caused by brain dysfunction that is easy to be
found in childhood, and it is common in children, adolescents, and adults. Although there is a lot of research on attention deficit
hyperactivity disorder (ADHD), there seems to be a lack of comprehensive research on educational strategies and their effects
on this disorder. This literature review attempts to discuss what ADHD is and some risk factors associated with the prevalence
of ADHD, the executive function problems associated with ADHD and related interventions, other possible interventions or
educational strategies, and ultimately, what kind of collaboration relationship should be achieved between the educator and the
parent or family will be discussed.
Teaching Research of “Pneumatic Control System Installation and Commissioning” Course Based on Job Competence Requirements
Authors: Han Daogang 
Published: July 2022

Most of the professional courses of engineering technology will follow the requirements of post ability, which is
helpful to improve the personal professional ability of vocational students and quickly adapt to the job requirements. In order to
achieve this goal, teaching methods should be reformed and post ability requirements should be integrated into the whole teaching
process. Thus, the students’ learning objectives are integrated with the teaching objectives, enhancing their interest in learning and
improving the learning effect.
Reflections on The Rectification of Online Education Model Under the “Internet +” Strategy
Authors: Bi Yueran 
Published: July 2022

In recent years, with the development of information technology, the Internet industry has developed rapidly. Especially
for the education industry, the integration of information technology and education has broken the traditional online education
model and brought a new source for educational reform. “Internet plus education” has not only received support at the national
level, but also been applied in many schools.In a word, online teaching mode is the product of the development of Internet in modern society, which has the importance of breaking the limitation of time and space, optimizing learning methods and integrating
high-quality resources, and should be supported by social practice.Online teaching should be based on task-driven network autonomous learning.Relevant companies should strengthen the construction of hardware facilities, promote the high-speed hormone of
software terminal operation, and stabilize it.The classroom setting of online education should be closer to the physical classroom,
and strengthen the communication and interaction between students and teachers.
Humanistic Solicitude in Robert Frost’s Out，Out
Authors: Zhang Jing 
Published: July 2022

Robert Frost tries to save the era occupied by industrial civilization with his poetry. His poems with primitive style
are simple and easy to understand, but they contain rich humanistic spirit. Out, Out, for example, is a concern for the survival of
people living on the land. The author satirizes the materialized and spiritualized times through the way of poetry, which reflects the
humanistic concern conveyed by him.
Teaching of Calculation methods Course Based on a Simple to Complex Perspective
Authors: Zhang Jie 
Published: July 2022

Starting from simple knowledge in teaching,the transformation of complex methods in computational methods into
combinations of simple methods is explained,which helps to improve teaching effectiveness.This paper analyzes the application
of the principle of moving from simple to complex in the teaching of computational methods through specific cases based on the
perspective of moving from simple to complex,and introduces the embodiment of the property of transforming complex problems
into combinations of simple problems in computational methods based on specific knowledge points.The paper will play an active
role in the teaching of computational methods course.
Pediatric Medulloblastoma: Prognostic Value of Preoperative Blood Cell Ratios
Authors: Alimohammadi Ehsan , Bagheri Seyed Reza , Arast Atefeh , Hadidi Homa , Safari-Faramani Roya 
Published: July 2022

Background: The prognostic significance of preoperative neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) have been demonstrated in various tumors. This study aimed to evaluate the prognostic role of these ratios in pediatric medulloblastoma.
Materials and Methods: Forty-three pediatric patients with medulloblastoma were evaluated, retrospectively. Clinical, radiological, and laboratory data were extracted from the electronic medical records of the patients. Univariate and multivariate Cox proportional hazard models were used to evaluate the impact of suggested variables, including NLR, LMR, and PLR on progression-free survival (PFS) and overall survival (OS). Kaplan-Meier curves were plotted for the assessment of PFS and OS. The Log-rank test was used to assess differences between the PFS and OS in the related categories.
Results: There were 27 males (62.8%) and 16 females (37.2%) with a mean age of 7.4 ±3.3 years. The median OS and PFS were 62.8 ±17.2 and 43.3 ±15.6 months, respectively. The multivariate Cox model showed the clinical risk group, NLR, and LMR as independent predictors of the PFS and the OS (p<0.05). The Log-rank test revealed that OS and PFS were higher in patients with NLR <4 and those with LMR ≥ 3.48 (p <0.05). There were no differences between patients with PLR>200 and PLR< 200 based on OS and PFS.
Conclusion: Our results suggest an elevated preoperative NLR and a lowered preoperative LMR as simple predictors of survival in pediatric medulloblastoma. These cost-effective and easily available ratios, along with previously established variables, could be valuable to predict survival in pediatrics with medulloblastoma.
Effect of High-Tone External Muscle Stimulation (High- Tone Therapy) in Neuro-Musculoskeletal Disorders: A Narrative Review
Authors: Namvar Hasan , Olyaie Gholamreza , Bagheri Hossein , Naiemi Ehsan , Hoseinifar Mohammad , Sargolzehi Maryam 
Published: July 2022

High-tone external muscle stimulation (HTEMS) or high-tone therapy is a new type of electrotherapy. Unlike the conventional electrotherapy that uses a fixed frequency, in HTEMS, the frequency and amplitude are simultaneously modulated, delivering much higher energy into the tissues. Recently, considerable attention has been paid to applying high-tone therapy in managing different disorders. This systematic study, therefore, was set out to assess the effect of high-tone therapy in various neuro-musculoskeletal disorders. After an exclusive search in databases of PubMed, Scopus, and Google Scholar, seven relevant studies were selected, including 3 studies for low back pain, 2 studies for peripheral neuropathy, 1 study in multiple sclerosis patients, and 1 preprint study on the subjects with anterior cruciate ligament reconstruction. PEDro (the physiotherapy evidence database) scale was used to assess the quality of the included articles. Although the studies reported that high-tone therapy significantly improved signs and symptoms, the low number and poor methodological quality of included studies do not allow determining certain effectiveness of HTEMS, and it could be an important reason for performing more research in the future.
Modified Hold-Relax Stretching Technique Combined with Moist Heat Therapy to Improve Neuromuscular Properties in College Students with Hamstring Tightness
Authors: Rani Khan Aysha , Sethi Kritika , Noohu Majumi M. 
Published: July 2022

Introduction: This study aims to evaluate the effect of modified hold-relax stretching combined with moist heat therapy on hamstring muscle flexibility, EMG activity and strength in college students with hamstring tightness.
Materials and Methods: Thirty-eight college students with hamstring tightness were recruited and were divided into two groups. Group 1 received modified hold-relax stretching plus moist heat therapy and Group 2 received moist heat therapy alone, three days a week for four weeks. The knee range of motion (ROM), muscle strength and Electromyography (EMG) activity before and after the treatment protocol were measured.
Results: There was no significant difference between the two groups in demographic characteristics. The knee ROM was significantly different between groups in terms of time (P=0.001) and group (P=0.005) effects, but the strength and EMG activity were not significantly different.
Conclusion: The modified hold-relax technique combined with moist heat therapy is effective in increasing hamstring flexibility, but has no significant effect on the muscle EMG activity and strength.
Narrow funnel-like interaction energy distribution is an indicator of specific protein interaction partner.
Authors: Choi Juyoung 
Published: July 2022

Abstract
Protein interaction networks underlie countless biological mechanisms. However, most protein interaction predictions are based on interspecies biological evidence (knowledge-based predictions) that are biased to well-known protein interaction or physical evidence that exhibits low accuracy for weak interactions and requires high computational power. In this study, a novel method has been suggested to predict protein interactions using interaction energy distribution. Protein interactions with specific partners can be predicted by investigating narrow funnel-like interaction energy distribution, exhibiting a stable state in a specific orientation. In this study, it was demonstrated that various protein interactions with specific interaction partner, such as protein interaction with kinase and E3 ubiquitin ligases, have narrow funnel-like interaction energy distribution. Moreover, algorithm and deep learning model for prediction of general protein interaction partner and substrate of kinase and E3 ubiquitin ligase were developed. The prediction accuracy of this method is similar to or even better than that of yeast two-hybrid screening, which is the most widely applied interaction screening method. Ultimately, this knowledge-free protein interaction prediction method will broaden our understanding of protein interaction networks.
Energy Generation Cost Without and With CO2 Capture for Power Plants
Authors: Chavez Rosa-Hilda 
Published: July 2022

Abstract
This work addresses the National Strategic Program on Energy Transition, of the Energy Sector Program 2020–2024, Mexican Energy Ministry. The Energy Transition states, "Reach a level of energy consumption that is sustainable in the long term and that contributes globally to the mitigation of climate change and energy sovereignty." To answer the statement, it is necessary to mitigate the production of CO2, as the main greenhouse gas, constantly emitted by power plants, by the combustion of fossils, and a primary source of energy. The CO2 capture process is energy intensive, so its study and search for the optimization of mass transfer, energy parameters and cost analysis are necessary for its widespread application. In the context of climate change mitigation, CO2 capture and sequestration (CCS), as well as its possible long-term storage, or preferably its use (CCUS), represent a technological route to neutralize CO2 emissions without leaving to use fossil fuels, during a period in which these fuels are replaced or their use rationalized by means of energy efficiency improvement methods. The objective of this work is to analyze the investment in electricity generation without and with CO2 capture process in three power plants in Mexico: Natural Gas Boiler, Open Cycle Natural Gas Turbine Boiler and Coal Boiler. Efficiency and cost results are presented in production by energy use in power plants; as well as experimental and theorical results for the capture of CO2 considering post-combustion technology by chemical absorption, with 30% Monoethanolamine in aqueous solution, and ININ 18 structured packing. With CO2 capture process, it was reduced 9.7%, meaning 596.0 kt/y for for natural gas boilers, 9.8% with 607.5 kt/year captured for gas turbine technology; and 9.9% with 2029 kt/year for coal. For the Energy Transition, by capturing CO2, the costs would increase by 14% with capture, on net power of 153 MW for a natural gas boiler; 4.5%, on 228 MW for the gas turbine boiler; and it is even reduced to 2%, on 302 MW for coal.
UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma
Authors: Kostyrko Kaja , Lee Alex , Román Marta , Simpson David , Dinh Phuong , Leung Stanley , Marini Kieren , Kelly Marcus , Broyde Joshua , Califano Andrea , Jackson Peter , Sweet-Cordero Alejandro 
Published: July 2022

Abstract
KRAS is one of the most frequently mutated oncogenes in lung cancer. To identify novel KRAS-specific vulnerabilities, we performed RNAi screens in spheroid cultures of primary tumor cells derived from a mouse model of lung cancer driven by activation of Kras and loss of p53. Ubiquitin-like containing PHD and RING finger domains 1 (UHRF1), an epigenetic regulator involved in DNA methylation, was identified as a gene selectively important for the 3D growth of primary tumor cells derived from this model. Further studies in human lung cancer cell lines confirmed that UHRF1 knock-out selectively impaired sphere growth and induced apoptosis in cells expressing oncogenic KRAS but had minimal effect on KRAS wild type or non-transformed lung cells. To understand its KRAS-specific role, we depleted UHRF1 in KRAS mutant lung cancer cell lines and analyzed genome-wide methylation and gene expression. UHRF1 loss led to global DNA hypomethylation resulting in the upregulation of lung cancer-specific tumor suppressor genes (TSGs). The majority of these TSGs were also overexpressed after KRAS loss, suggesting a mechanistic link between UHRF1 and KRAS-driven oncogenic phenotypes. In vivo, UHRF1 knock-out impaired tumor growth in mouse models of KRAS-driven lung cancer. Finally, analysis of lung cancer patient data revealed that high UHRF1 expression is anti-correlated with TSG expression and predicts worse outcomes for patients with tumors harboring KRAS mutations. These results in human cells and mouse models identify UHRF1 as a KRAS-specific vulnerability and a potential target for therapeutic intervention.