bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genes that are Used Together are More Likely to be Fused Together in Evolution by Mutational Mechanisms: A Bioinformatic Test of the Used-Fused Hypothesis
Authors: Bolotin Evgeni , Melamed Daniel , Livnat Adi 
Published: November 2022

AbstractCases of parallel or recurrent gene fusions in evolution as well as in genetic disease and cancer are difficult to explain, because unlike point mutations, they can require the repetition of a similar configuration of multiple breakpoints rather than the repetition of a single point mutation. The used-together-fused-together hypothesis holds that genes that are used together repeatedly and persistently in a specific context are more likely to undergo fusion mutation in the course of evolution for mechanistic reasons. This hypothesis offers to explain gene fusion in both evolution and disease under one umbrella. Using bioinformatic data, we tested this hypothesis against alternatives, including that all gene pairs can fuse by random mutation, but among pairs thus fused, those that had interacted previously are more likely to be favored by selection. Results show that across multiple measures of gene interaction, human genes whose orthologs are fused in one or more species are more likely to interact with each other than random pairs of genes of the same genomic distance between pair members; that an overlap exists between genes that fused in the course of evolution in non-human species and genes that undergo fusion in human cancers; and that across six primate species studied, fusions predominate over fissions and exhibit substantial evolutionary parallelism. Together, these results support the used-together-fused-together hypothesis over its alternatives. Multiple implications are discussed, including the relevance of mutational mechanisms to the evolution of genome organization, to the distribution of fitness effects of mutation, to evolutionary parallelism and more.
Politik auf der Straße? Zum Forschungsstand zu sozialen Bewegungen, Protest und Zivilgesellschaft
Authors: Weisskircher Manès 
Published: November 2022

ZusammenfassungSoziale Bewegungen prägen zeitgenössische Gesellschaften. Dieser Beitrag diskutiert die wesentlichen Erkenntnisse der internationalen Bewegungs- und Protestforschung und ordnet den Forschungsstand ein. Das Ziel ist es, die Aufmerksamkeit sozialwissenschaftlicher Forschung verstärkt auf Politik „auf der Straße“ zu lenken. Dabei fokussiert der Artikel auf vier zentrale Fragestellungen: die definitorische Annäherung an das Phänomenon (was sind soziale Bewegungen?), ihre Formierung (wann und warum entstehen soziale Bewegungen?), ihre Aktionsformen (wie agieren soziale Bewegungen?) sowie ihre Auswirkungen (welchen Einfluss haben soziale Bewegungen?). Abschließend plädiert der Beitrag für eine enge Verknüpfung von Bewegungs- und Protestforschung mit der Parteienforschung und der politischen Soziologie. Protest ist nicht bloßl’art pour l’art: Ohne eine Bezugnahme auf Parteipolitik und Gesellschaftsanalyse bleibt das Verständnis von sozialen Bewegungen begrenzt. Andererseits würde die Analyse von (Partei‑)Politik und gesellschaftlichen Makro-Entwicklungen von einer verstärkten Berücksichtigung sozialer Bewegungen profitieren.
New species from the early Eocene London Clay suggest an undetected early Eocene diversity of the Leptosomiformes, an avian clade that includes a living fossil from Madagascar
Authors: Mayr Gerald , Kitchener Andrew C. 
Published: November 2022

AbstractWe report the first records of the leptosomiform taxonPlesiocathartesfrom the early Eocene London Clay of Walton-on-the-Naze (Essex, UK). Two species could be distinguished, one of which is described asPlesiocathartes insolitipes, sp. nov. (the other is classified asPlesiocathartessp.). We furthermore describe two small leptosomiform-like birds from Walton-on-the-Naze,Waltonavis paraleptosomus, gen. et sp. nov. andW. danielsi, gen. et sp. nov., which are represented by partial skeletons of multiple individuals. In plesiomorphic characters of the coracoid and furcula, the new taxonWaltonavisis distinguished fromPlesiocathartesand the extantLeptosomus; the skull ofWaltonavisfurthermore exhibits basipterygoid processes, which are absent inLeptosomus. Another new species,Lutavis platypelvis, gen. et sp. nov., is based on a partial skeleton from Walton-on-the-Naze and closely resemblesPlesiocathartesin the overall shape of the tarsometatarsus. However,L. platypelvisis clearly distinguished from leptosomiform birds in the morphology of the hypotarsus, the more massive coracoid, and other skeletal features. Although we consider close affinities toPlesiocathartesand, hence, the Leptosomiformes to be possible, we could not identify derived characters that enable an unambiguous phylogenetic placement ofL. platypelvis. In any case, the new species document an unexpected diversity ofPlesiocathartes-like fossil in the London Clay and may open a new perspective for a reconstruction of the ancestral morphology of the avian clade Afroaves, which includes the Leptosomiformes and other arboreal landbirds.
Assessment the impact of different fuels used in cement industry on pollutant emissions and ambient air quality: a case study in Egypt
Authors: Sayad Tarek , Moursy Fawzia Ibrahim , El-Tantawi Attia M. , Saad Mohamed , Morsy Mostafa 
Published: November 2022

AbstractThis study aims to assess the impact of using different fuels in Egyptian Titan Alexandria Portland Cement Company on emissions and concentrations of pollutants (Total suspended particles (TSP), nitrogen dioxide (NO2‎), and sulfur dioxide (SO2)) and their influence on ambient air quality during the period 2014–2020 using AERMOD dispersion model. The results showed that changing the fuel from natural gas in 2014 to coal mixed with alternative fuels (Tire-Derived Fuel (TDF), Dried Sewage Sludge (DSS), and Refuse Derived Fuels (RDF)) in 2015–2020 caused fluctuating variations in pollutant emissions and concentrations. The highest and lowest maximum concentrations of TSP occurred in 2017 and 2014 respectively, where the TSP is positively correlated with coal, RDF, and DSS and negatively correlated with natural gas, diesel, and TDF. Also, the lowest and highest maximum NO2 concentrations were detected in 2020 and 2016 followed by 2017 respectively, where NO2 is positively correlated with DSS and negatively correlated with TDF and varies with diesel, coal, and RDF. Moreover, the maximum concentrations of SO2 were the lowest in 2018 and highest in 2016 followed by 2017 because of its considerable positive correlation with natural gas and DSS and negative correlation with RDF, TDF, and coal. Generally, it was found that increasing the percentage of TDF and RDF with decreasing the percentage of DSS, diesel, and coal will reduce pollutant emissions and concentrations and enhance ambient air quality.
Mental Performance and Sport: Caffeine and Co-consumed Bioactive Ingredients
Authors: Kennedy David O. , Wightman Emma L. 
Published: November 2022

AbstractThe plant defence compound caffeine is widely consumed as a performance enhancer in a sporting context, with potential benefits expected in both physiological and psychological terms. However, although caffeine modestly but consistently improves alertness and fatigue, its effects on mental performance are largely restricted to improved attention or concentration. It has no consistent effect within other cognitive domains that are important to sporting performance, including working memory, executive function and long-term memory. Although caffeine’s central nervous system effects are often attributed to blockade of the receptors for the inhibitory neuromodulator adenosine, it also inhibits a number of enzymes involved both in neurotransmission and in cellular homeostasis and signal propagation. Furthermore, it modulates the pharmacokinetics of other endogenous and exogenous bioactive molecules, in part via interactions with shared cytochrome P450 enzymes. Caffeine therefore enjoys interactive relationships with a wide range of bioactive medicinal and dietary compounds, potentially broadening, increasing, decreasing, or modulating the time course of their functional effects, or vice versa. This narrative review explores the mechanisms of action and efficacy of caffeine and the potential for combinations of caffeine and other dietary compounds to exert psychological effects in excess of those expected following caffeine alone. The review focusses on, and indeed restricted its untargeted search to, the most commonly consumed sources of caffeine: products derived from caffeine-synthesising plants that give us tea (Camellia sinensis), coffee (Coffeagenus), cocoa (Theabroma cacao) and guaraná (Paullinia cupana), plus multi-component energy drinks and shots. This literature suggests relevant benefits to mental performance that exceed those associated with caffeine for multi-ingredient energy drinks/shots and several low-caffeine extracts, including high-flavanol cocoa and guarana. However, there is a general lack of research conducted in such a way as to disentangle the relative contributions of the component parts of these products.
Line Sampling Procedure for Extensive Planetary Protection Analysis
Authors: Romano Matteo , Colombo Camilla , Pérez José Manuel Sánchez 
Published: November 2022

AbstractExploration missions to other planets have to satisfy planetary protection requirements to limit the probability of impacts between mission-related objects and celestial bodies, with the goal of reducing the risk of contaminating them with biological material coming from Earth. The verification of these requirements can become a lengthy and computationally expensive task when addressed with common methods such as Monte Carlo simulations, as they involve analysing the interplanetary trajectories and the uncertainties associated with them for time spans up to 100 years, and estimating small probabilities with strict confidence levels. This paper presents novel improvements of the line sampling method, already introduced for the verification of planetary protection requirements as a way to estimate the impact probabilities more efficiently and with greater accuracy than achieved with standard Monte Carlo. These newly developed techniques are presented, with the aim of making the analysis with Line Sampling more effective, and providing more information about the distribution of impacts in the initial uncertainty distribution: an algorithm to identify the time intervals where most close approaches are clustered, and an algorithm to improve the determination of the main sampling direction and increase the accuracy of the probability estimation.
Facies, Geochemistry, and Ceramic Properties of Corumbataí Formation, Upper Permian of Paraná Basin, and its Application in the Ceramic Industry, Brazil
Authors: Christofoletti Sergio Ricardo , Batezelli Alessandro , Moreno Maria Margarita Torres 
Published: November 2022

AbstractThe supply of Corumbataí Formation rocks, which occur widely in the State of São Paulo, Brazil, and are used by Santa Gertrudes Ceramic Cluster, is dwindling and prospecting for new deposits is essential. The current study aimed to map and characterize new reserves of ceramic raw materials which would guarantee mineral and economic sustainability of the important concentration of ceramic-processing capability in that area, and thereby contribute to improving and diversifying the range of products manufactured and to promoting a greater presence in the international market. To achieve the proposed objectives, 16 profiles were sampled and the samples were submitted to granulometric analysis by laser diffraction, and the major elements by inductively coupled plasma-mass spectrometry, and the mineralogical compositions of clay samples were determined by X-ray diffraction and ceramic properties. Six lithofacies were identified and grouped into two facies associations: a lower shoreface association comprising massive siltstone (Sm) and laminated siltstone (Sl); lithofacies, and an upper shoreface association comprising heterolithic sandstone (Sh), lenticular sandstone (Sle), intercalated sandstone/siltstone (Si), and altered siltstone (Sa) lithofacies. The lithofacies of the lower shoreface association were more clayey, flux with a significant presence of illite and microcline, and a more uniform granulometry distribution, which made its classification possible, technologically, as stoneware and semi stoneware. The main application of this material is in the production of coatings through the wet milling process. The lithofacies of the upper shoreface association was sandier, had a refractory presence with kaolinite and montmorillonite, and had a less uniform granulometric distribution; technologically, it can be characterized as porous and semi-porous. The main application of this material is in the production of coatings by the dry milling process. The results obtained by facies analysis combined with the geochemical and ceramic properties of the Corumbataí Formation rocks revealed both vertical and lateral variations of the lithofacies, which influence their properties, behavior, and application as ceramic raw materials.
From data to practice change – exploring new territory for atlases of clinical variation
Authors: Levesque Jean-Frederic , Sutherland Kim 
Published: November 2022

AbstractDespite decades of atlas production and use within multiple healthcare systems, and consistent reporting of geographical differences in the utilisation of services, significant levels of clinical variation persist. Drawing on over forty years of combined experience using atlases of clinical variation, we reflect on why that might be the case and explore the role of atlases have played in efforts to reduce inappropriate overuse, underuse and misuse of healthcare services. We contend that atlases are useful but, on their own, are not enough to drive change in clinical practice and improvement in patient outcomes. Building on four conceptual models we have published since 2017, we argue that atlases, with their focus on measuring healthcare utilisation by residents in different geographies, generally fail to provide sufficient information and statistical analyses to truly assess the nature of the variation and support action for change. They seldom use structures such as hospitals or teams as the unit of analysis to understand variation; they rarely feature the key elements of healthcare performance which underlie variation; they are mostly silent about how to assess whether the variation measured is warranted or truly unwarranted; nor do they identify evidence-based levers for change. This means that a stark choice confronts producers of atlases – to either continue with the current model and more explicitly rely on other players to undertake work to complete the ‘data to action’ cycle that is necessary to secure improvement; or to refine their offering – including more sophisticated performance measurement approaches, nuanced guides for interpretation of any differences found, support for the selection and application of levers for change that align with local context, and provision of evidence-based options for implementation.
The onset of mass loss in evolved stars
Authors: McDonald Iain 
Published: November 2022

AbstractTo look at propagating winds from evolved stars into the interstellar medium is to look at how they are sustained. To understand their origins, we must look to the circumstances that create them in the first instance. In this article, I examine the physical conditions under which pulsation-enhanced, dust-driven winds are first generated. These initial conditions can help constrain the late evolutionary stages of these stars and provide insight into the mechanisms that cause the mass loss itself.
The origin and impact of Wolf-Rayet-type mass loss
Authors: Sander Andreas A. C. , Vink Jorick S. , Higgins Erin R. , Shenar Tomer , Hamann Wolf-Rainer , Todt Helge 
Published: November 2022

AbstractClassical Wolf-Rayet (WR) stars mark an important stage in the late evolution of massive stars. As hydrogen-poor massive stars, these objects have lost their outer layers, while still losing further mass through strong winds indicated by their prominent emission line spectra. Wolf-Rayet stars have been detected in a variety of different galaxies. Their strong winds are a major ingredient of stellar evolution and population synthesis models. Yet, a coherent theoretical picture of their strong mass-loss is only starting to emerge. In particular, the occurrence of WR stars as a function of metallicity (Z) is still far from being understood.To uncover the nature of the complex and dense winds of Wolf-Rayet stars, we employ a new generation of model atmospheres including a consistent solution of the wind hydrodynamics in an expanding non-LTE situation. With this technique, we can dissect the ingredients driving the wind and predict the resulting mass-loss for hydrogen-depleted massive stars. Our modelling efforts reveal a complex picture with strong, non-linear dependencies on the luminosity-to-mass ratio and Z with a steep, but not totally abrupt onset for WR-type winds in helium stars. With our findings, we provide a theoretical motivation for a population of helium stars at low Z, which cannot be detected via WR-type spectral features. Our study of massive He-star atmosphere models yields the very first mass-loss recipe derived from first principles in this regime. Implementing our first findings in stellar evolution models, we demonstrate how traditional approaches tend to overpredict WR-type mass loss in the young Universe.
The Link between Hot and Cool Outflows
Authors: Vink Jorick S. , Sander A.A.C. , Higgins E.R. , Sabhahit G.N. 
Published: November 2022

AbstractThe link between hot and cool stellar outflows is shown to be critical for correctly predicting the masses of the most massive black holes (BHs) below the so-called pair-instability supernova (PISN) mass gap. Gravitational Wave (GW) event 190521 allegedly hosted an “impossibly” heavy BH of 85 M⊙. Here we show how our increased knowledge of both metallicity Z and temperature dependent mass loss is critical for our evolutionary scenario of a low-Z blue supergiant (BSG) progenitor of an initially approx 100 M⊙ star to work. We show using MESA stellar evolution modelling experiments that as long as we can keep such stars above 8000 K such low-Z BSGs can avoid strong winds, and keep a very large envelope mass intact before core collapse. This naturally leads to the Cosmic Time dependent maximum BH function below the PISN gap.
Accretion-powered Outflows in AGB Stars
Authors: Sahai Raghvendra , Sanz-Forcada Jorge , Sanchez-Contreras Carmen 
Published: November 2022

AbstractOne of the big challenges for 21st century stellar astrophysics is the impact of binary interactions on stellar evolution. Such interactions are believed to play a key role in the death throes of 1-8 M⊙ stars, as they evolve from the AGB stars into Planetary Nebulae. X-ray surveys of UV-emitting AGB stars show that ∼40% of objects with FUV emission and GALEX FUV/NUV flux ratios ≳0.2 have variable X-ray emission characterized by very high temperatures (Tx∼35-160 MK) and luminosities (Lx∼0.002-0.2L⊙). We hypothesize that such AGB stars have accretion and (accretion-powered) outflows associated with a close binary companion. UV spectroscopy with HST/STIS of our brightest object (Y Gem) shows the presence of infalling and outflowing gas, providing direct kinematic confirmation of this hypothesis. However, the UV-emitting AGB star population is dominated by objects with little or no FUV emission, and we do not know whether the UV emission from these is intrinsic to the AGB star or extrinsic (i.e., due to binarity). Here we present the first results from a large grid of simple chromospheric models to help discriminate between the intrinsic and extrinsic mechanisms of UV emission for AGB stars.
Mass–loss rates of cool evolved stars in M 33 galaxy
Authors: Javadi Atefeh , van Loon Jacco Th. 
Published: November 2022

AbstractWe have conducted a near-infrared monitoring campaign at the UK InfraRed Telescope (UKIRT), of the Local Group spiral galaxy M 33 (Triangulum). In this paper, we present the dust and gas mass-loss rates by the pulsating Asymptotic Giant Branch (AGB) stars and red supergiants (RSGs) across the stellar disc of M 33.
Birth and Decline of Magma Oceans in Planetesimals: 2. Structure and Thermal History of Early Accreted Small Planetary Bodies
Authors: Sturtz Cyril , Limare Angela , Tait Stephen , Kaminski Édouard 
Published: November 2022

AbstractThis is the second of two companion papers that present a theoretical and experimental study of the thermal history of planetesimals in which heating by short‐lived radioactive isotopes generates an internal magma ocean and the subsequent cooling and crystallization thereof. We study the conditions required to form and preserve basal cumulates and flotation crusts, and the implications for the thermal evolution of planetary bodies. Our model predicts that planetesimals larger than 30 km can reach 1300°C and a melt fraction of 40 vol%, producing a solid‐like to liquid‐like rheological transition that triggers an internal magma ocean. In the magma ocean regime core‐mantle differentiation occurs very quickly and the mantle convects under a relic of chondritic material whose thickness is controlled by the temperature of rheological transition. We show that the magma ocean episode is associated with time‐dependent crystal segregation and no re‐entrainment. Segregation of crystals is essentially constrained by their size and by their density difference with respect to the melt, the latter being fully determined by the planetesimal's initial composition. Olivine cumulates are likely to form at the core‐mantle boundary. Under certain particular conditions, a flotation crust can also form, which reduces the efficiency of heat evacuation by convection, thereby enhancing the magma ocean's lifetime and the efficiency of crystal segregation. Two types of large‐scale mantle structure are possible outcomes: a well‐mixed upper mantle above an olivine cumulate, or a more finely layered “onion‐shell” structure.
South Pacific Ocean Dynamics Redistribute Ocean Heat Content and Modulate Heat Exchange With the Atmosphere
Authors: Fernandez Denise , Bowen Melissa , Sutton Philip 
Published: November 2022

AbstractThe correlation of global ocean surface temperatures with ocean heat content (OHC) at interannual to decadal time scales shows wind‐driven ocean circulation plays a fundamental role in the Earth's energy balance. Wind‐driven baroclinic Rossby waves contribute to the adjustment of the ocean circulation to the winds modulating OHC at mid‐latitudes. Here we use observational records, a reanalysis and a Rossby wave model to quantify the contribution of the waves to the variations in air‐sea heat flux. We find that Rossby waves crossing the South Pacific at 35°S can explain up to 70% of the interannual variance of the heat flux. The heat exchange attributed to the waves, ranging from −9 to 21 W m−2, has contributed to the multi‐year increase in heat in the central Pacific. Heat fluxes due to Rossby waves could be forecast to provide predictability of this component of the heat exchange with the atmosphere.