bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental stress and depression symptoms among B40 wives of drug addicts in Malaysia: Resilience as a mediator
Authors: Ahmad Shahril Nurul Saidatus Shaja'ah , Arshat Zarinah , Adnan Haikal Anuar 
Published: August 2022

Background: The prevalence of depression is higher among women in the general population. While previous studies have contributed to demonstrating a higher risk of depression among women, there is a scarcity of studies on depression issues among women who experienced life as a spouse to drug addicts. Therefore, the present study aimed to investigate the association between parental stress faced in raising children and depression. Moreover, the study intended to examine the impact of parental stress on depression as mediated by resilience. Methods: Using the purposive sampling method, a total of 132 B40 wives of drug addicts were chosen to participate in this study. Data were collected from six states in Malaysia using a structured questionnaire consisting of the Parental Stress Scale (PSS), Brief Resilience Scale (BRS), and Zung’s Self-Rating Depression Scale (SDS). SmartPLS software version 3.3.7 was used to analyze the data collected. Results: Path analysis revealed that parental stress was significantly associated with depression through resilience. Specifically, the indirect effect highlighted that resilience was a partial mediator in the association between parental stress and depression. Nevertheless, it is also shown that even after accounting for the mediating role of resilience, parental stress still has a positive impact on depression. Conclusions: The present study proffers additional strategies to drug addicts’ wives, advocates, academicians, practitioners, and policymakers to approach depression issues in this community for better well-being.
The effect of betel habits on blood glucose levels in the Karo ethnic community, Karo district
Authors: Pane Yunita Sari , Machrina Yetty , Arrasyid Nurfida Khairina , Sari Mutiara Indah 
Published: August 2022

Background: Betel habit is a hereditary tradition from the ancestors of the Batak-Karo tribe, Indonesia. Karo people believe that betel habit is their unifier. The betel process begins with concocting a mixture of ingredients such as betel leaf, lime, gambier, areca nut, and with/ without tobacco addition, then chewed slowly. Our previous study showed that gambier extracts (Uncaria gambier Roxb), can reduce blood glucose levels(BGL) in type 2 diabetes mellitus (T2DM)patients. This study aimed to analyze whether the habit of chewing betel can affect BGL in the Karo ethnic community in the Karo district.Methods: In total, 48 participants from the Karo community were divided into 4 groups (n=12 per group), namely: I. non-T2DM participants without betel habits; II. non-T2DM participants with betel habit; III. T2DM participants without betel habit and IV. T2DM participants with betel habit. The sampling technique was consecutive sampling. Data were collected by interviews and blood sampling (fasting and 2 hours postprandial (2hPP)). The collected data analyzed by paired t-test, Independent sample t-test, Wilcoxon, and Mann-Whitney with a significance level of p-value <0.05.Results: This study showed that fasting BGL condition in group-I compared to group II (84.33±12.32 vs 81.00±4.84) mg/dl and group-III compared to group-IV (196.25±104.81 vs 150.00±42.45) mg/dl had no significant difference. Also, the BGL of 2hPP condition in group-I compared to group-II (111.25 ±22.62 vs 108.33±18.99) mg/dl, and group-III compared to group-IV (314.92±128.97 vs 229.25±58.26) mg/dl, in statistically there was no difference (p>0.05). Although the data showed that group-III was higher than group-IV.Conclusions: This study concludes that with/without betel habits affect blood sugar levels in type 2 diabetes subjects (Groups III and IV).
Comparing QuantiFERON-TB Gold Plus with QuantiFERON-TB Gold in-tube for diagnosis of latent tuberculosis infection among highly TB exposed gold miners in South Africa
Authors: Ntshiqa Thobani , Chihota Violet , Mansukhani Raoul , Nhlangulela Lindiwe , Velen Kavindhran , Charalambous Salome , Maenetje Pholo , Hawn Thomas R. , Wallis Robert , Grant Alison D. , Fielding Katherine , Churchyard Gavin 
Published: August 2022

Background: QuantiFERON-TB-Gold-in-tube (QFT-GIT) is an interferon-gamma release assay (IGRA) used to diagnose latent tuberculosis infection. Limited data exists on performance of QuantiFERON-TB Gold-Plus (QFT-Plus), a next generation of IGRA that includes an additional antigen tube 2 (TB2) while excluding TB7.7 from antigen tube 1 (TB1), to measure TB specific CD4+ and CD8+ T lymphocytes responses. We compared agreement between QFT-Plus and QFT-GIT among highly TB exposed goldminers in South Africa. Methods: We enrolled HIV-negative goldminers in South Africa, aged ≥33 years with no prior history of TB disease or evidence of silicosis. Blood samples were collected for QFT-GIT and QFT-Plus. QFT-GIT was considered positive if TB1 tested positive; while QFT-Plus was positive if both or either TB1 or TB2 tested positive, as per manufacturer's recommendations. We compared the agreement between QFT-Plus and QFT-GIT using Cohen’s Kappa. To assess the specific contribution of CD8+ T-cells, we used TB2−TB1 differential values as an indirect estimate. A cut-off value was set at 0.6. Logistic regression was used to identify factors associated with having TB2-TB1>0.6 difference on QFT-Plus. Results: Of 349 enrolled participants, 304 had QFT-Plus and QFT-GIT results: 205 (68%) were positive on both assays; 83 (27%) were negative on both assays while 16 (5%) had discordant results. Overall, there was 94.7% (288/304) agreement between QFT-Plus and QFT-GIT (Kappa = 0.87). 214 had positive QFT-Plus result, of whom 202 [94.4%, median interquartile range (IQR): 3.06 (1.31, 7.00)] were positive on TB1 and 205 [95.8%, median (IQR): 3.25 (1.53, 8.02)] were positive on TB2. A TB2-TB1>0.6 difference was observed in 16.4% (35/214), with some evidence of a difference by BMI; 14.9% (7/47), 9.8% (9/92) and 25.3% (19/75) for BMI of 18.5-24.9, 18.5-25 and >30 kg/m 2, respectively (P=0.03). Conclusion: In a population of HIV-negative goldminers, QFT-Plus showed high agreement with QFT-GIT, suggesting similar performance.
Developing a core outcome set (COS) for Dementia with Lewy bodies (DLB)
Authors: Grycuk Emilia , Eichenholtz Emily , Aarsland Dag , Betzhold Sara , Daly Gillian , Folkerts Ann-Kristin , Kalbe Elke , Kane Joseph PM , Kinchin Irina , Saldanha Ian J , Smith Valerie , Taylor John-Paul , Thompson Rachel , Leroi Iracema 
Published: August 2022

Background: Dementia with Lewy bodies (DLB) is an important cause of dementia with a range of clinical manifestations, including motor, neuropsychiatric, and autonomic symptoms. Compared with more common forms of dementia such as Alzheimer’s disease, DLB has been the focus of significantly fewer treatment studies, often with diverse outcome measures, making comparison and clinical implementation difficult. A core outcome set (COS) can address this by ensuring that data are comparable, relevant, useful, and usable for making the best healthcare decisions. Methods: Using a multi-stage approach, development of the DLB-COS will include the following stages: (1) A systematic review, following PRISMA guidelines to create an initial long list of outcomes; (2) A two-round online Delphi including clinicians, scientists, policymakers, and individuals with lived experience of DLB and their representatives; (3) An online consensus meeting to agree on the final core list of outcomes (the final DLB-COS) for use in research and clinical practice; (4) A literature search to identify appropriate measurement instruments for the DLB-COS outcomes; (5) A final consensus meeting of the professional stakeholders who attended the online consensus meeting to agree on the instruments that should be used to measure the outcomes in the DLB-COS; and (6) Global dissemination. Discussion: This is a multi-stage project to develop a COS to be used in treatment trials for DLB. A DLB-COS will ensure the selection of relevant outcomes and will identify the instruments to be used to measure DLB globally.
Tumor suppressors inhibit reprogramming of African spiny mouse (Acomys) fibroblasts to induced pluripotent stem cells
Authors: Sandoval Aaron Gabriel W. , Maden Malcolm , Bates Lawrence E. , Silva Jose C.R. 
Published: August 2022

Background: The African spiny mouse (Acomys) is an emerging mammalian model for scar-free regeneration, and further study of Acomys could advance the field of regenerative medicine. Isolation of pluripotent stem cells from Acomys would allow for development of transgenic or chimeric animals and in vitro study of regeneration; however, the reproductive biology of Acomys is not well characterized, complicating efforts to derive embryonic stem cells. Thus, we sought to generate Acomys induced pluripotent stem cells (iPSCs) by reprogramming somatic cells back to pluripotency. Methods: To generate Acomys iPSCs, we attempted to adapt established protocols developed in Mus. We utilized a PiggyBac transposon system to genetically modify Acomys fibroblasts to overexpress the Yamanaka reprogramming factors as well as mOrange fluorescent protein under the control of a doxycycline-inducible TetON operon system. Results: Reprogramming factor overexpression caused Acomys fibroblasts to undergo apoptosis or senescence. When SV40 Large T antigen (SV40 LT) was added to the reprogramming cocktail, Acomys cells were able to dedifferentiate into pre-iPSCs. Although use of 2iL culture conditions induced formation of colonies resembling Mus PSCs, these Acomys iPS-like cells lacked pluripotency marker expression and failed to form embryoid bodies. An EOS-GiP system was unsuccessful in selecting for bona fide Acomys iPSCs; however, inclusion of Nanog in the reprogramming cocktail along with 5-azacytidine in the culture medium allowed for generation of Acomys iPSC-like cells with increased expression of several naïve pluripotency markers. Conclusions: There are significant roadblocks to reprogramming Acomys cells, necessitating future studies to determine Acomys-specific reprogramming factor and/or culture condition requirements. The requirement for SV40 LT during Acomys dedifferentiation may suggest that tumor suppressor pathways play an important role in Acomys regeneration and that Acomys may possess unreported cancer resistance.
Unexpectedly long progression-free time in a patient with squamous cell carcinoma of the lung treated with Nivolumab – a case study.
Authors: Szklener Katarzyna , Piwowar Klaudia , Klas Jakub , Kluz Natalia , Mańdziuk Sławomir 
Published: August 2022

Background: In the reported case, our patient with lung cancer diagnosed as squamous cell carcinoma (SqCC) achieved eight times longer progression-free time (PFT; 25.3 months) than that obtained in the median of randomized clinical trials (3.5 months).
Case Report: A 61-year-old man presented for treatment due to a long-lasting cough and a type of pain in the chest, in good general condition. The patient had a smoking history when he was young. Computed tomography (CT) showed a lesion larger than 70 x 60 mm. The diagnosis was made on the basis of the bronchoscopic material. The prognosis was unfavorable and the tumor was inoperable. In the first line of treatment, chemotherapy with cisplatin was started. Due to the progression, second-line immunotherapy with Nivolumab was administered, and was continued for a longer period of time. Treatment was well tolerated and there were no side effects reported. Therapy was however interrupted due to the patient's deteriorating condition and progression in the follow up CT examination. Finally the patient was qualified for palliative treatment with chemotherapy and zoledronic acid. Opioid medications were used to treat pain.
Conclusion: The patient lived for over 4 years, including over 2 years without progression. It therefore seems that there is a group of patients who respond exceptionally well to immunotherapy, but the identification of predictors requires further research.
Profit Effects of Consumers’ Identity Management: A Dynamic Model
Authors: Laussel Didier , Van Long Ngo , Resende Joana 
Published: August 2022

We consider a nondurable good monopolist that collects data on its customers in order to profile them and subsequently practice price discrimination on returning customers. The monopolist’s price discrimination scheme is leaky in the sense that an endogenous fraction of consumers choose to incur a privacy cost to conceal their identity when they return in the following periods. We characterize the Markov perfect equilibrium of the game under two alternative customer profiling regimes: full information acquisition (FIA) and purchase history information (PHI). In both cases, we find that, contrary to what could be expected, the monopolist’s aggregate profit is not monotonically increasing in the level of the privacy cost, but a U-shaped function of it, leading to ambiguous profit effects: a reduction in privacy costs increases the fraction of customers who choose to be anonymous (detrimental profit effect), but it also softens the firm’s introductory price, reducing the pace at which prices targeted to new customers fall over time (positive profit effect). When comparing results under FIA and PHI, we find that market expansion is faster, and more customers conceal their identity under FIA than under PHI. Equilibrium profits are also higher in the FIA case. Although equilibrium profits are U-shaped functions of the privacy cost in both profiling regimes, they tend to be globally decreasing with the privacy cost under PHI and globally increasing under FIA. This paper was accepted by Eric Anderson, marketing. Funding: This work was supported by Fundação para a Ciência e a Tecnologia [Grants NORTE-01-0145-FEDER-028540 and POCI-01-0145-FEDER-006890]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2022.4511 .
Can We Detect Malicious Behaviours in Encrypted DNS Tunnels Using Network Flow Entropy?
Authors: Khodjaeva Yulduz , Zincir-Heywood Nur , Zincir Ibrahim 
Published: August 2022

This paper explores the concept of entropy of a flow to augment flow statistical features for encrypted DNS tunnelling detection, specifically DNS over HTTPS traffic. To achieve this, the use of flow exporters, namely Argus, DoHlyzer and Tranalyzer2 are studied. Statistical flow features automatically generated by the aforementioned tools are then augmented with the flow entropy. In this work, flow entropy is calculated using three different techniques: (i) entropy over all packets of a flow, (ii) entropy over the first 96 bytes of a flow, and (iii) entropy over the first n-packets of a flow. These features are provided as input to ML classifiers to detect malicious behaviours over four publicly available datasets. This model is optimized using TPOT-AutoML system, where the Random Forest classifier provided the best performance achieving an average F-measure of 98% over all testing datasets employed.
Optimization of an all-optical three-input universal logic gate with an enhanced contrast ratio by exploiting a T-shaped photonic crystal waveguide
Authors: Rachana Maddala , Swarnakar Sandip , Babu Mallavarapu Rajan , Swetha Paradesi Mary , Rangaiah Yagateela Pandu , Krishna Sabbi Vamshi , Kumar Santosh 
Published: August 2022

Universal gates (NAND and NOR) are used for any electronic circuit that is affordable and straightforward to build all logic gates (LoG). In this work, the T-shaped 2D photonic crystal (PhC) is exploited to design a three-input universal LoG premised on the beam-interference principle. The design criteria of pitch (

a

), rod radius (

r

), and refractive index (

n

) are employed to obtain a high impact output. The methodologies of plane wave expansion and finite-difference time-domain are employed for examining the framework of universal LoG at 1550 nm wavelengths (

λ

). The suggested universal LoG design has a compact size of

8.4

µ

m

×

4.8

µ

m

. Additionally, the structure yields a high contrast ratio (CR) of 20.37 dB for the NAND LoG and 28.45 dB for the NOR LoG, and maximum transmission efficiency of 50.6% and 70% for the NAND and NOR gates; correspondingly, the best and worst three-input NAND gate response times are 19.5 ps and 21.4 ps. Similarly, the response time of the three-input NOR gate is 26 ps. The proposed universal gate’s primary goal is to offer a high CR and a compact structure while being compatible with any other logic gate.
The use of mobile apps and fitness trackers to promote healthy behaviors during COVID-19: A cross-sectional survey
Authors: Tong Huong Ly , Maher Carol , Parker Kate , Pham Tien Dung , Neves Ana Luisa , Riordan Benjamin , Chow Clara K. , Laranjo Liliana , Quiroz Juan C. 
Published: August 2022

Objectives
To examine i) the use of mobile apps and fitness trackers in adults during the COVID-19 pandemic to support health behaviors; ii) the use of COVID-19 apps; iii) associations between using mobile apps and fitness trackers, and health behaviors; iv) differences in usage amongst population subgroups.

Methods
An online cross-sectional survey was conducted during June–September 2020. The survey was developed and reviewed independently by co-authors to establish face validity. Associations between using mobile apps and fitness trackers and health behaviors were examined using multivariate logistic regression models. Subgroup analyses were conducted using Chi-square and Fisher’s exact tests. Three open-ended questions were included to elicit participants’ views; thematic analysis was conducted.

Results
Participants included 552 adults (76.7% women; mean age: 38±13.6 years); 59.9% used mobile apps for health, 38.2% used fitness trackers, and 46.3% used COVID-19 apps. Users of mobile apps or fitness trackers had almost two times the odds of meeting aerobic physical activity guidelines compared to non-users (odds ratio = 1.91, 95% confidence interval 1.07 to 3.46, P = .03). More women used health apps than men (64.0% vs 46.8%, P = .004). Compared to people aged 18–44 (46.1%), more people aged 60+ (74.5%) and more people aged 45–60 (57.6%) used a COVID-19 related app (P < .001). Qualitative data suggest people viewed technologies (especially social media) as a ‘double-edged sword’: helping with maintaining a sense of normalcy and staying active and socially connected, but also having a negative emotional effect stemming from seeing COVID-related news. People also found that mobile apps did not adapt quickly enough to the circumstances caused by COVID-19.

Conclusions
Use of mobile apps and fitness trackers during the pandemic was associated with higher levels of physical activity, in a sample of educated and likely health-conscious individuals. Future research is needed to understand whether the association between using mobile devices and physical activity is maintained in the long-term.
Single housing but not changes in group composition causes stress-related immunomodulations in horses
Authors: Schmucker Sonja , Preisler Vanessa , Marr Isabell , Krüger Konstanze , Stefanski Volker 
Published: August 2022

Domestic horses are currently often subject to management practices that can entail social stressors, which in turn can negatively influence immunocompetence and disease susceptibility.
The present study therefore aimed to characterize the number of various blood leukocyte subsets in horses, focusing on two potentially stressful housing environments: changes in group composition and relocation to individual stabling. Immune measurements were conducted before as well as one and eight days after changes were made. They were complemented by an assessment of plasma cortisol concentrations as well as behavioral observations. One and eight days after relocation to single housing, the mean numbers of eosinophils, T helper cells and cytotoxic T cells decreased by up to 31%, 20% and 22% respectively, whereas the mean numbers of neutrophils increased by 25%. In contrast, one and eight days after changes in group composition not only the mean number of neutrophils, but also of monocytes, T helper cells and cytotoxic T cells increased by up to 24%, 17%, 9%, and 15% respectively. In consequence, an increase in the neutrophil-to-lymphocyte ratio indicating stress-induced immune modulation was found after relocation to single housing, but not after changes in group composition. The changes in leukocyte numbers after relocation to single housing were accompanied by a transient increase in cortisol concentrations after one day and the occurrence of disturbed behavior patterns one week after change in housing condition. In contrast, changes in group composition did not result in an increase of cortisol concentrations or in an increase of aggressive interactions. The results strongly indicate that individual stabling is an intense stressor leading to acute and lasting alterations in blood counts of various leukocyte types. The study highlights a probable negative impact of single housing on welfare and health of horses and an advantage of group housing systems in view of immunocompetence.
Cost-effectiveness of alternative minimum recall intervals between whole blood donations
Authors: Sadique Zia , Willis Sarah , Corte Kaat De , Pennington Mark , Moore Carmel , Kaptoge Stephen , Angelantonio Emanuele Di , Miflin Gail , Roberts David J. , Grieve Richard 
Published: August 2022

Background
The INTERVAL trial showed shorter inter-donation intervals could safely increase the frequency of whole-blood donation. We extended the INTERVAL trial to consider the relative cost-effectiveness of reduced inter-donation intervals.

Methods
Our within-trial cost-effectiveness analysis (CEA) used data from 44,863 whole-blood donors randomly assigned to 12, 10 or 8 week (males), and 16, 14 or 12 week inter-donation intervals (females). The CEA analysed the number of whole-blood donations, deferrals including low- haemoglobin deferrals, and donors’ health-related quality of life (QoL) to report costs and cost-effectiveness over two years.

Findings
The mean number of blood donation visits over two years was higher for the reduced interval strategies, for males (7.76, 6.60 and 5.68 average donations in the 8-, 10- and 12- week arms) and for females (5.10, 4.60 and 4.01 donations in the 12-, 14- and 16- week arms). For males, the average rate of deferral for low haemoglobin per session attended, was 5.71% (8- week arm), 3.73% (10- week), and 2.55% (12- week), and for females the rates were: 7.92% (12-week), 6.63% (14- week), and 5.05% (16- week). Donors’ QoL was similar across strategies, although self-reported symptoms were increased with shorter donation intervals. The shorter interval strategies increased average cost, with incremental cost-effectiveness ratios of £9.51 (95% CI 9.33 to 9.69) per additional whole-blood donation for the 8- versus 12- week interval for males, and £10.17 (95% CI 9.80 to 10.54) for the 12- versus 16- week interval arm for females.

Conclusions
Over two years, reducing the minimum donation interval could provide additional units of whole-blood at a small additional cost, including for those donor subgroups whose blood type is in relatively high demand. However, the significance of self-reported symptoms needs to be investigated further before these policies are expanded.