bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features of otogenic cerebral sinovenous thrombosis: Our experience and review of literature
Authors: Abir Meherzi , Amal Gdissa , Mouna Bellakhdher , Malika Omri , Habiba Ben Sghaier , Jihen Houas , Wassim Kermani , Mohamed Abdelkefi 
Published: October 2022

AbstractOtogenic cerebral sinovenous thrombosis is an intracranial complication secondary to otogenic disease; it is rare but could be a life‐threatening condition. Its management is always challenging. This study aimed to focus on clinical features, on diagnosis of this pathology and to review the most controversial aspect of management of otogenic cerebral sinovenous thrombosis. We reviewed retrospectively 10 inpatients treated with cerebral sinus thrombosis secondary to otitis between 1995 and 2020. Ten inpatients (eight males and two females) with ages ranging from 11 to 77 years were diagnosed with ontogenesis sinus thrombosis. The most commonly reported symptoms were headaches and otalgia. Five patients had mastoiditis, and 7 of the 10 patients had other concurrent complications: cerebellar abscess (three patients) and extradural empyema in two patients, retropharyngeal abscess in one patient, and meningitis in one patient. All patients were treated with broad‐spectrum antibiotherapy, anticoagulation was used to treat nine patients, and surgery was required in nine patients. Nine patients had satisfactory resolution of their symptoms, but one patient had sequel as permanent loss of visual acuity. Because of the inconspicuous clinical presentation, and the probability of a fatal evolution, suspicion is essential for a proper diagnosis and suitable treatment.
Extraction and purification of paeonol from Moutan Cortex by a combined method of steam distillation and antisolvent recrystallization to reduce energy consumption and carbon dioxide emissions
Authors: Wang Siying , Xie Lanlan , Yang Qilei , Geng Yuting , Kang Hedi , Zhao Xiuhua 
Published: October 2022

AbstractThis study aimed to obtain paeonol with high purity by using the combination of steam distillation and antisolvent recrystallization (ASR) and to reduce the energy consumption and CO2 emission in the preparation process. First, different experimental parameters were optimized by response surface methodology (RSM). Under the optimal conditions, the purity and yield of the as‐obtained paeonol were about 98% and 56.97%, respectively. The physicochemical properties of purified paeonol were tested, showing consistency with those of standard paeonol. The energy consumption and CO2 emission of the preparation process of ASR and single‐solvent recrystallization were also investigated. Results showed that the energy consumption and CO2 emission of ASR were about 4.41 J/mg and 0.006 kg/mg, respectively, which were 6.89 J/mg and 0.0095 kg/mg lower than those of ethanol recrystallization, respectively, and 50.22 J/mg and 0.0144 kg/mg lower than methanol those of recrystallization, respectively. The above results showed that ASR could obtain paeonol with high purity in a high‐efficiency, low‐energy, and environmentally protective manner.
Molecular profiling of patients with cytogenetically normal acute myeloid leukemia and hyperleukocytosis
Authors: Pastore Friederike , Pastore Alessandro , Rothenberg‐Thurley Maja , Metzeler Klaus H. , Ksienzyk Bianka , Schneider Stephanie , Bohlander Stefan K. , Braess Jan , Sauerland Maria C. , Görlich Dennis , Berdel Wolfgang E. , Wörmann Bernhard , von Bergwelt‐Baildon Michael S. , Hiddemann Wolfgang , Spiekermann Karsten 
Published: October 2022

AbstractBackgroundAcute myeloid leukemia (AML) with initial hyperleukocytosis is associated with high early mortality and a poor prognosis. The aims of this study were to delineate the underlying molecular landscape in the largest cytogenetic risk group, cytogenetically normal acute myeloid leukemia (CN‐AML), and to assess the prognostic relevance of recurrent mutations in the context of hyperleukocytosis and clinical risk factors.MethodsThe authors performed a targeted sequencing of 49 recurrently mutated genes in 56 patients with newly diagnosed CN‐AML and initial hyperleukocytosis of ≥100 G/L treated in the AMLCG99 study. The median number of mutated genes per patient was 5. The most common mutations occurred in FLT3 (73%), NPM1 (75%), and TET2 (45%).ResultsThe predominant pathways affected by mutations were signaling (84% of patients), epigenetic modifiers (75% of patients), and nuclear transport (NPM1; 75%) of patients. AML with hyperleukocytosis was enriched for molecular subtypes that negatively affected the prognosis, including a high percentage of patients presenting with co‐occurring mutations in signaling and epigenetic modifiers such as FLT3 internal tandem duplications and TET2 mutations.ConclusionsDespite these unique molecular features, clinical risk factors, including high white blood count, hemoglobin level, and lactate dehydrogenase level at baseline, remained the predictors for overall survival and relapse‐free survival in hyperleukocytotic CN‐AML.
An effective blockchain‐based smart contract system for securing electronic medical data in smart healthcare application
Authors: Sonya Ansar , Kavitha Ganesh 
Published: October 2022

SummaryIn today's world, data management plays a key role in smart healthcare applications. However, data availability, trustworthiness, confidentiality, and security are the major issues faced by current healthcare data management systems. The modern healthcare systems manage Electronic Medical Records (EMR) using a centralized manner, which increases the single point of failure in the event of a natural catastrophe. In this paper, a new robust Blockchain‐based Medical Cloud (BC‐MedCl) framework has been proposed to provide secure EMR sharing between patient and doctor. Primarily, Internet of Things (IoT) devices will gather the health‐related data of the patient periodically. The proposed framework then stores the encrypted EMRs in cloud storage while their correlating hash values are placed into the blockchain. Finally, a decentralized selective smart contract‐based access control mechanism is developed to enhance the security of the proposed system. The prototype file‐sharing performance of the proposed architecture has been evaluated using the Ethereum platform. The performance results manifest that the proposed blockchain framework is more effective to handle EMR in the real‐time healthcare system with a superior accuracy ratio of 98.7% and a lesser latency ratio of 25% as compared with the existing systems.
Ionic Conjugated Polymers as Heterogeneous Catalysts for the Cycloaddition of Carbon Dioxide to Epoxides to Form Carbonates under Solvent‐ and Cocatalyst‐Free Conditions
Authors: Xiao Longqiang , Lai Yiming , Zhao Rui , Song Qianyu , Cai Jingyu , Yin Xiangyu , Zhao Yulai , Hou Linxi 
Published: October 2022

AbstractThe generation of cyclic carbonates by the cycloaddition of CO2 with epoxides is attractive in the industry, by which CO2 is efficiently used as C1 source. Herein, a series of catalysts were developed to efficient mediate the cycloaddition of CO2 with epoxides to generate carbonates. The catalysts were easily synthesized via the amine‐formaldehyde condensation of ethidium bromide with a variety of linkers. The newly prepared heterogeneous catalysts have high thermal stability and degradation temperatures. The surface of the catalysts is smooth and spherical in shape. The effect of temperature, pressure, reaction time and catalyst dosage on the cycloaddition of CO2 with epoxide were investigated. The results show that the catalyst with 1,3,5‐tris(4‐formylphenyl)benzene as the linker can achieve 97.4 % conversion efficiency at the conditions of 100 °C, reaction time of 12 h, and the reaction pressure of 1.2 MPa in a solvent‐free environment. Notably, the polymers serve as homogeneous catalysts during the reaction (reaction temperature above Tg) and can be separated and recovered easily as homogeneous catalysts at room temperature. In addition, the catalyst is not only suitable for a wide range of epoxide substrates, but also can be recycled many times. Furthermore, DFT calculations show that the coordination between the electrophilic center of the catalyst and the epoxide reduces the energy barrier, and the reaction mechanism is proposed based on the reaction kinetic studies and DFT calculations.
LLC resonant converter based on PFM and secondary‐side short‐circuit control for on‐board charger
Authors: Tang Yu , Zhao Baolin , Shi Zhe , Jiang Lin , Zhang Yun 
Published: October 2022

AbstractCommonly used lithium‐ion battery on‐board charger (OBC) for electric vehicles (EVs) needs a wide output voltage range, but the traditional LLC converter is hard to meet the need under the condition of high efficiency and high power density. In this paper, a resonant converter with hybrid modulation is proposed. The converter has a relatively simple topology and control method. Compared with the traditional LLC topology, only two diodes are replaced by MOSFETs on the secondary side of the transformer, and no auxiliary components are added. The primary‐side switches adopt PFM) and the secondary‐side switches adopt short‐circuit control in the proposed converter, which can realize a wide output voltage range, in a narrow switching frequency range with excellent soft‐switching performance. The proposed converter can effectively reduce the resonant current and the volume of transformer core and achieve energy delivery with high power density and high efficiency. The operation principles, voltage gain, and soft‐switching conditions of the converter are analyzed in this paper. Finally, a 3.3‐kW SiC‐based prototype with 400‐V input and 250‐ to 430‐V output is built to verify the feasibility and validity of the proposed converter.
Toward five‐part differential of leukocytes based on electrical impedances of single cells and neural network
Authors: Wang Minruihong , Tan Huiwen , Li Yimin , Chen Xiao , Chen Deyong , Wang Junbo , Chen Jian 
Published: October 2022

AbstractThe five‐part differential of leukocytes plays key roles in the diagnosis of a variety of diseases and is realized by optical examinations of single cells, which is prone to various artifacts due to chemical treatments. The classification of leukocytes based on electrical impedances without cell treatments has not been demonstrated because of limitations in approaches of impedance acquisition and data processing. In this study, based on treatment‐free single‐cell impedance profiles collected from impedance flow cytometry leveraging constriction microchannels, two types of neural pattern recognition were conducted for comparisons with the purpose of realizing the five‐part differential of leukocytes. In the first approach, 30 features from impedance profiles were defined manually and extracted automatically, and then a feedforward neural network was conducted, producing a classification accuracy of 84.9% in the five‐part leukocyte differential. In the second approach, a customized recurrent neural network was developed to process impedance profiles directly and based on deep learning, a classification accuracy of 97.5% in the five‐part leukocyte differential was reported. These results validated the feasibility of the five‐part leukocyte differential based on label‐free impedance profiles of single cells and thus provide a new perspective of differentiating white blood cells based on impedance flow cytometry.
Evaluation of rockburst proneness considering specimen shape by storable elastic strain energy
Authors: Luo Song , Gong Fengqiang 
Published: October 2022

AbstractTo systematically assess the rockburst proneness considering specimen shape, multiple groups of laboratory tests were performed on 5 rock materials in cylindrical and cuboid shapes. The linear energy storage (LES) law of both cylindrical and cuboid rock specimens under uniaxial compressive load was confirmed, and the energy storage coefficient was found to be unrelated to specimen shape. On the basis of LES law, two rockburst proneness indexes, namely the strain energy storage index (Wet) and the potential energy of elastic strain (PES), were modified. Subsequently, the Wet, PES, peak‐strength strain energy storage index (, and peak‐strength potential energy of elastic strain (PESp) were used to assess the rockburst proneness of the cylindrical and cuboid specimens. In addition, the fragment ejection course of specimens under test was recorded by a high‐speed camera. Then, the rockburst proneness judgments obtained from the 4 indexes were compared with the qualitative data during rock destruction. The results show that, under similar stress conditions, specimen shape has an ignorable effect on the rockburst proneness as a whole. The judgment accuracy of the two modified indexes, especially that of the PESp, is favorably improved to evaluate the rockburst proneness of both cylindrical and cuboid specimens. However, misjudgment of and PESp may still occur in the assessment of rockburst proneness as these two indexes only consider the energy state before rock peak strength and the is formulated in a ratio form.
Aquatic ecosystem responds differently to press and pulse nutrient disturbances as revealed by a microcosm experiment
Authors: Zhao Yu , Wang Rong , Zhang Enlou , Guan Baohua , Xu Min 
Published: October 2022

AbstractDue to climate change and increasing anthropogenic activities, lakes are disturbed frequently, usually by press (e.g., diffused pollution, rising temperatures) or pulse (e.g., storms, rainfall, pollution events) disturbances. Both press and pulse disturbances can affect abiotic and biotic environments, changing the structure of ecosystems and affecting ecosystem services. To confront with the effects of climate change and increasing anthropogenic activities, understanding the different effects of press and pulse disturbances on lake ecosystems is essential. This study assessed the effect of press and pulse disturbances of phosphorus on a microcosmic aquatic ecosystem by measuring the total phosphorus (TP), algae density, and physiological indicators of submerged macrophytes. We found that the microcosmic aquatic ecosystem responded differently to press and pulse disturbances. Our results suggested that it had a lower resistance to pulse phosphorus disturbances than to press phosphorus disturbances. There were significantly higher nutrient concentrations and algal densities in the pulse treatment than in the press treatment. Positive feedback was found between the biomass of submerged macrophytes and the water quality. There was a higher submerged macrophytes biomass at low TP concentration and algal density. In the context of climate change, press and pulse disturbances could have severe impacts on lake ecosystems. Our findings will provide some insight for further research and lake management.
An innovative approach to using an intensive field course to build scientific and professional skills
Authors: Nicotra Adrienne B. , Geange Sonya R. , Bahar Nur H. A. , Carle Hannah , Catling Alexandra , Garcia Andres , Harris Rosalie J. , Head Megan L. , Jin Marvin , Whitehead Michael R. , Zurcher Hannah , Beckmann Elizabeth A. 
Published: October 2022

AbstractThis paper reports on the design and evaluation of Field Studies in Functional Ecology (FSFE), a two‐week intensive residential field course that enables students to master core content in functional ecology alongside skills that facilitate their transition from “student” to “scientist.” We provide an overview of the course structure, showing how the constituent elements have been designed and refined over successive iterations of the course. We detail how FSFE students: (1) Work closely with discipline specialists to develop a small group project that tests an hypothesis to answer a genuine scientific question in the field; (2) Learn critical skills of data management and communication; and (3) Analyze, interpret, and present their results in the format of a scientific symposium. This process is repeated in an iterative “cognitive apprenticeship” model, supported by a series of workshops that name and explicitly instruct the students in “hard” and “soft” skills (e.g., statistics and teamwork, respectively) critically relevant for research and other careers. FSFE students develop a coherent and nuanced understanding of how to approach and execute ecological studies. The sophisticated knowledge and ecological research skills that they develop during the course is demonstrated through high‐quality presentations and peer‐reviewed publications in an open‐access, student‐led journal. We outline our course structure and evaluate its efficacy to show how this novel combination of field course elements allows students to gain maximum value from their educational journey, and to develop cognitive, affective, and reflective tools to help apply their skills as scientists.
Effects of plant communities on the emission of soil greenhouse gases in riparian wetlands during spring thaw
Authors: Cao Xiaoai , Tang Shiming , Liu Huamin , Wen Lu , Kou Xin , Yu Xiaowen , Wang Qi , Wang Jian , Liu Dongwei , Zhuo Yi , Wang Lixin 
Published: October 2022

AbstractSpring thawing can affect the soil carbon and nitrogen cycling processes and lead to changes in the emissions of greenhouse gases. The temporal variations and impact factors of soil GHGs fluxes were measured in Phragmites australis and Carex appendiculata with the static chamber from the end of March to the end of May in 2018 in riparian wetlands of Xilin River, which is typical inland river meandering through steppe region in Inner Mongolia, China. The results showed that soil CH4 and N2O emissions of the P. australis were significantly higher than those of the Carex appendiculata, whereas CO2 emissions were no significant difference. The responses of soil GHG fluxes to soil environmental factors in P. australis and Carex appendiculata differed. In the P. australis community, soil CO2 and CH4 emissions were influenced jointly by mainly the soil temperature and microbial biomass nitrogen, whereas soil N2O emission was mainly affected by the soil temperature. The dominant controlling factor for CO2 and N2O was soil temperature in the Carex appendiculata, whereas CH4 was mainly regulated by soil water content. The global warming potential of P. australis was significantly higher than that of Carex appendiculata. Those findings highlight the difference in soil greenhouse gas fluxes in different plant communities and the importance of CH4 and N2O emissions during the spring thaw, which contributes to predicting the riparian wetland soil greenhouse gases and their global warming potential under global climate changes.
Room Temperature Synthesis of Vertically Aligned Amorphous Ultrathin NiCo‐LDH Nanosheets Bifunctional Flexible Supercapacitor Electrodes
Authors: Owusu Kwadwo Asare , Wang Zhaoyang , Saad Ali , Boakye Felix Ofori , Mushtaq Muhammad Asim , Tahir Muhammad , Yasin Ghulam , Liu Dongqing , Peng Zhengchun , Cai Xingke 
Published: October 2022

Developing a simple scalable method to fabricate electrodes with high capacity and wide voltage range is desired for the real use of electrochemical supercapacitors. Herein, we synthesized amorphous NiCo‐LDH nanosheets vertically aligned on activated carbon cloth substrate, which was in situ transformed from Co‐metal–organic framework materials nano‐columns by a simple ion exchange process at room temperature. Due to the amorphous and vertically aligned ultrathin structure of NiCo‐LDH, the NiCo‐LDH/activated carbon cloth composites present high areal capacities of 3770 and 1480 mF cm−2 as cathode and anode at 2 mA cm−2, and 79.5% and 80% capacity have been preserved at 50 mA cm−2. In the meantime, they all showed excellent cycling performance with negligible change after >10 000 cycles. By fabricating them into an asymmetric supercapacitor, the device achieves high energy densities (5.61 mWh cm−2 and 0.352 mW cm−3). This work provides an innovative strategy for simplifying the design of supercapacitors as well as providing a new understanding of improving the rate capabilities/cycling stability of NiCo‐LDH materials.
Long‐term mortality after acute coronary syndromes among patients with normal, mildly reduced, or reduced ejection fraction
Authors: Furtado Remo H.M. , Juliasz Marcela G. , Chiu Felipe Y.J. , Bastos Livia B.C. , Dalcoquio Talia F. , Lima Felipe G. , Rosa Renato , Caporrino Cesar A. , Bertolin Adriadne , Genestreti Paulo R.R. , Ribeiro Andre S. , Andrade Maria Carolina , Giraldez Roberto R.C.V. , Baracioli Luciano M. , Zelniker Thomas A. , Nicolau Jose C. 
Published: October 2022

AbstractAimsLeft ventricular ejection fraction (LVEF) ≤ 40% is a well‐established risk factor for mortality after acute coronary syndromes (ACS). However, the long‐term prognostic impact of mildly reduced ejection fraction (EF) (LVEF 41–49%) after ACS remains less clear.Methods and resultsThis was a retrospective study enrolling patients admitted with ACS included in a single‐centre databank. LVEF was assessed by echocardiography during index hospitalization. Patients were divided in the following categories according to LVEF: normal (LVEF ≥ 50%), mildly reduced (LVEF 41–49%), and reduced (LVEF ≤ 40%). The endpoint of interest was all‐cause death after hospital discharge. A multivariable Cox model was used to adjust for confounders. A total of 3200 patients were included (1952 with normal EF, 375 with mildly reduced EF, and 873 with reduced EF). The estimated cumulative incidence rates of mortality at 10 years for patients with normal, mildly reduced, and reduced EF were 24.8%, 33.5%, and 41.3%, respectively. After adjustments, the presence of reduced EF was associated with higher mortality compared with normal EF [adjusted hazard ratio (HR) 1.64; 95% confidence interval (CI) 1.36–1.96; P < 0.001], as was mildly reduced EF compared with normal EF (adjusted HR 1.33; 95% CI 1.05–1.68; P = 0.019). The presence of reduced EF was not associated with a statistically significantly higher mortality compared with mildly reduced EF (adjusted HR 1.23; 95% CI 0.96–1.57; P = 0.095).ConclusionsIn patients with ACS, mildly reduced EF measured in the acute phase was associated with higher long‐term mortality compared with patients with normal EF. These data emphasize the importance of anti‐remodelling therapies for ACS patients who have LVEF in the mildly reduced range.
IL‐13 determines specific IgE responses and SARS‐CoV‐2 immunity after mild COVID‐19 and novel mRNA vaccination
Authors: Meltendorf Stefan , Vogel Katrin , Thurm Christoph , Prätsch Florian , Reinhold Annegret , Färber Jacqueline , Heuft Hans‐Gert , Kaasch Achim J. , Hachenberg Thomas , Weinzierl Stefan , Schraven Burkhart , Reinhold Dirk , Brunner‐Weinzierl Monika C. , Lingel Holger 
Published: October 2022

AbstractAfter recovery, mild and severe COVID‐19 diseases are associated with long‐term effects on the host immune system, such as prolonged T‐cell activation or accumulation of autoantibodies. In this study, we show that mild SARS‐CoV‐2 infections, but not SARS‐CoV‐2 spike mRNA vaccinations, cause durable atopic risk factors such as a systemic Th2‐ and Th17‐type environment as well as activation of B cells responsive of IgE against aeroallergens from house dust mite and mold. At an average of 100 days post mild SARS‐CoV‐2 infections, anti‐mold responses were associated with low IL‐13 levels and increased pro‐inflammatory IL‐6 titers. Acutely severely ill COVID‐19 patients instead showed no evidence of atopic reactions. Considering convalescents of mild COVID‐19 courses and mRNA‐vaccinated individuals together, IL‐13 was the predominant significantly upregulated factor, likely shaping SARS‐CoV‐2 immunity. Application of multiple regression analysis revealed that the IL‐13 levels of both groups were determined by the Th17‐type cytokines IL‐17A and IL‐22. Taken together, these results implicate a critical role for IL‐13 in the aftermath of SARS‐CoV‐2 mild infections and mRNA vaccinations, conferring protection against airway directed, atopic side reactions that occur in mildly experienced COVID‐19.