bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEVELOPMENT OF DATABASE STRUCTURES AND DATA EXCHANGE PRINCIPLES FOR NUCLEAR DECOMMISSIONING PLANNING
Authors: Daniška Dušan , Vrban Branislav , Nečas Vladimír 
Published: August 2022

Abstract
The amount and variety of information used during the nuclear decommissioning project is enormous. If we consider that data and information coming from the whole operational phase of a nuclear power plant (NPP) is important for safe and efficient planning of such projects and waste treatment, packaging, storage and disposal use data coming from the dismantling operations, we can expect that nuclear decommissioning data are live and can be useful for decades. Taking into account a very broad variety of such data (e.g. but not only, their format, storage media, structure, meaning, relevancy, …) it is not a trivial task to develop a complex and reasonably structured database for storing all this information. This paper presents an overview of our research activities in the field of standardization in terms of the data structure and storage technologies and outlines the overall ‘single-source-of-truth’ architecture with centralized server and communication principles for storage and transfer of data used in nuclear decommissioning projects.
EMANATION OF RADON-222 FROM DIFFERENT SOIL TYPES AND SOIL GROUPS
Authors: Eckertová Terézia , Holý Karol , Müllerová Monika , Sýkora Ivan , Masarik Jozef 
Published: August 2022

Abstract
In this paper, we deal with measurement of 222Rn emanation coefficient (Ke) of soils using an accumulation method. We created a database of Ke values of dried soils for various soil types and soil groups, classified by the size of soil particles. For 18 different soil samples we obtained the Ke values in range 0.083–0.234. The analysis of radon emanation dependence on moisture for seven of these samples shows two different trends which were related to soil texture (clays or sands). Soils with predominant sandy particles prove weak dependence on moisture and Ke values from minimum value (at zero moisture) do not increase much (max 15% increase on every 5% of moisture), for soils with majority of clayey particles the moisture can affect the Ke more significantly (increase up to 60%).
SleepMat: a new behavioral analysis software program for sleep and circadian rhythms
Authors: Sisobhan Shiju , Rosensweig Clark , Lear Bridget C , Allada Ravi 
Published: August 2022

Abstract

Study Objectives
To develop a new publicly available software SleepMat that analyzes Drosophila Activity Monitoring system data.

Methods
The software is built on Matlab platform, employs an easy-to-use graphic user interface, and is highly flexible to customize data inputs.

Results
This software provides large number of sleep and circadian parameters including period, actogram, anticipation, sleep amount, bout length, bout number, activity, sleep deprivation, latency, lifespan, and eduction results.

Conclusions
This software will enable a user-friendly high throughput analysis of a broad range of sleep and circadian parameters that can be coupled to the power of Drosophila genetics.
A toolkit for enhanced reproducibility of RNASeq analysis for synthetic biologists
Authors: Garcia Benjamin J , Urrutia Joshua , Zheng George , Becker Diveena , Corbet Carolyn , Maschhoff Paul , Cristofaro Alexander , Gaffney Niall , Vaughn Matthew , Saxena Uma , Chen Yi-Pei , Gordon D Benjamin , Eslami Mohammed 
Published: August 2022

Abstract
Sequencing technologies, in particular RNASeq, have become critical tools in the design, build, test and learn cycle of synthetic biology. They provide a better understanding of synthetic designs, and they help identify ways to improve and select designs. While these data are beneficial to design, their collection and analysis is a complex, multistep process that has implications on both discovery and reproducibility of experiments. Additionally, tool parameters, experimental metadata, normalization of data and standardization of file formats present challenges that are computationally intensive. This calls for high-throughput pipelines expressly designed to handle the combinatorial and longitudinal nature of synthetic biology. In this paper, we present a pipeline to maximize the analytical reproducibility of RNASeq for synthetic biologists. We also explore the impact of reproducibility on the validation of machine learning models. We present the design of a pipeline that combines traditional RNASeq data processing tools with structured metadata tracking to allow for the exploration of the combinatorial design in a high-throughput and reproducible manner. We then demonstrate utility via two different experiments: a control comparison experiment and a machine learning model experiment. The first experiment compares datasets collected from identical biological controls across multiple days for two different organisms. It shows that a reproducible experimental protocol for one organism does not guarantee reproducibility in another. The second experiment quantifies the differences in experimental runs from multiple perspectives. It shows that the lack of reproducibility from these different perspectives can place an upper bound on the validation of machine learning models trained on RNASeq data.
Graphical Abstract
Does Sleep Quality Influence Recovery Outcomes After Postconcussive Injury in Children and Adolescents?
Authors: Fisher Michael , Wiseman-Hakes Catherine , Obeid Joyce , DeMatteo Carol 
Published: August 2022

Objective:
To determine whether objective parameters of sleep quality differ throughout recovery between children and adolescents who experienced an early return to school (RTS) and those who had a delayed RTS or did not return at all during the study period.

Setting:
Sleep parameters reflective of sleep quality were evaluated in participants' natural sleeping habitat throughout 9 weeks postinjury.

Participants:
Ninety-four children and adolescents (aged 5-18 years) with diagnosed concussion.

Design:
Prospective cohort. Participants followed RTS protocols.

Main Measures:
Actigraphy-derived estimates of total sleep time (TST), sleep efficiency (SE), wake after sleep onset (WASO), average arousal length (AAL), and number of arousals (NOAs) per hour were assessed. The length of time from injury until RTS was determined for each participant. Participants were categorized into an early RTS or delayed RTS group based on their time to RTS.

Results:
Both TST and SE were significantly greater in the early RTS group. WASO duration, AAL, and NOAs were significantly greater in the delayed RTS group. Differences between RTS groups were most apparent during weeks 1 to 5 postinjury.

Conclusions and Clinical Implications:
Participants who returned to school earlier had significantly better objective sleep quality than participants who experienced a delayed RTS. This study provides evidence in support of a relationship between sleep quality and time to RTS in children and adolescents with concussion. Considering early monitoring of sleep, education regarding sleep hygiene, and access to age-appropriate sleep interventions may be helpful in pediatric concussion recovery.
Hypersensitivity to Noise and Light Over 1 Year After Mild Traumatic Brain Injury: A Longitudinal Study on Self-Reported Hypersensitivity and Its Influence on Long-Term Anxiety, Depression, and Quality of Life
Authors: Marzolla Marilien C. , Wijenberg Melloney , Stapert Sven , Hurks Petra , Schepers Jan , van Heugten Caroline 
Published: August 2022

Objective:
This study aimed to investigate (1) the prevalence of self-reported sensory hypersensitivity (noise [NS] and light [LS]) over 1 year after mild traumatic brain injury (mTBI) in adults and (2) the impact of NS and LS measured 2 weeks after injury on long-term outcomes 12 months postinjury, while controlling for postconcussion symptoms.

Setting:
Participants were recruited from 6 hospitals in the south of the Netherlands and were tested 4 times (2 weeks, 3 months, 6 months, and 12 months postinjury), using self-report questionnaires.

Participants:
In total, 186 mTBI participants (diagnosed using WHO [World Health Organization]/EFNS [European Federation of Neurological Societies] criteria at the neurology/emergency department) and 181 participants with a minor orthopedic injury in their extremities (control group).

Design:
An observational, longitudinal, multicenter cohort study.

Main Measures:
NS and LS items (Rivermead Post-Concussion Symptoms Questionnaire) were used as main outcome variables to determine sensory hypersensitivity symptoms. Additional outcomes included anxiety, depression, health-related quality of life (HRQoL), and life satisfaction.

Results:
There was an elevated prevalence of NS and LS between 2 weeks and 3 months after injury in the mTBI group compared with controls. Approximately 3% of mTBI patients had persistent hypersensitivity symptoms during the whole course of the study. At 12 months postinjury, the mTBI and control groups did not differ in the prevalence of persistent hypersensitivity symptoms. There was no evidence of a predictive value of hypersensitivity within 2 weeks postinjury on anxiety, depression, HRQoL, or life satisfaction, 12 months later after controlling for postconcussion symptoms.

Conclusions:
These results not only confirm the presence of hypersensitivity symptoms after mTBI in the subacute stage but also provide assurance about the small size of the group that experiences persistent symptoms. Furthermore, there was no evidence that early NS and LS are uniquely associated with long-term emotional and quality-of-life outcomes, over and above general levels of postconcussion symptoms.
Novice Accuracy in Ultrasound and Stethoscope Study (NAUSS)
Authors: Howell Christopher M. , Kaelin Andrea L. , Pennington Brian M. , Sillaman Jake D. , Bonk Megan R. , Rogers Vanessa S. 
Published: August 2022

Introduction
The purpose of this noninferiority study was the accurate determination of valvular heart disease, using bedside echocardiogram as compared to stethoscope, by a novice clinician examiner.

Methods
We conducted a single university, single program study to investigate the use of bedside ultrasound in the hands of a novice clinical user, defined as someone with fewer than 2 years of clinical education. We enrolled 8 examinees with evidence of valvular heart disease to be assessed by 13 subjects.

Results
Descriptive statistics revealed echocardiogram accuracy of 56% compared to 44% accuracy with stethoscope, though not statistically significant. Interestingly, 31% of subjects obtained equal measures with both instruments. Correlation proficiency between both modalities was also observed.

Discussion
There is no statistically significant difference in novice examiner diagnostic accuracy using point-of-care echocardiograms for examination of valvular heart disease when compared with a stethoscope.
Treatment Fidelity in a Randomized Controlled Trial of Cognitive Behavioral Therapy for Insomnia in Heart Failure
Authors: O’Connell Meghan , Iennaco Joanne DeSanto , Linsky Sarah , Jeon Sangchoon , Conley Samantha , Gaiser Edward , Redeker Nancy S. 
Published: August 2022

Abstract

Background
Cognitive behavioral therapy for insomnia (CBT-I) is an efficacious treatment for people with chronic insomnia, including those with heart failure (HF). Treatment fidelity evaluation is needed to ensure study validity and reliability.

Objective
To apply the National Institutes of Health Behavioral Change Consortium framework to ensure adequate treatment fidelity in a randomized controlled trial of CBT-I for people with stable HF.

Methods
We describe strategies to ensure treatment fidelity in study design, provider training, and treatment delivery. We measured treatment receipt (observation and self-report) and enactment of CBT-I strategies (self-report and actigraphy). We used the Dysfunctional Beliefs and Attitudes About Sleep Scale (DBAS) and the Sleep Disturbance Questionnaire (SDQ) to indicate sleep-related beliefs and cognitions. We computed descriptive statistics for demographic characteristics, treatment receipt, and enactment variables. We compared baseline and post-intervention dichotomous sleep behaviors using the two-sided Wilcoxon Rank Sum Test. We calculated the root mean square of successive difference (RMSSD) in time of sleep onset and midpoint (actigraphy) to indicate day-by-day variability in bed and wake times.

Results
Most participants completed the CBT-I intervention and follow-up assessments and attended each group or make-up session. The majority correctly computed their sleep efficiency and completed the homework. Most participants used the sleep tracker and reported using strategies to improve their sleep schedules. There was a significant decrease in actigraph-measured light intensity during the 30 min and 1 hr before bedtime between baseline and post-intervention and no statistically significant changes in light intensity after waking or in nap frequency. Most of those who woke during the night got out of bed, consistent with recommendations. There were significant improvements on all of the DBAS items and total score and all but one item on the SDQ.

Discussion
Preserved treatment fidelity may explain the large and sustained effects in people with HF found in our trial. Further research is needed to evaluate CBT-I’s effectiveness and implementation strategies among people with HF in real-world clinical settings.
“Ultrasound Findings in Patients with Normal Nerve Conduction Despite Clinical Signs and Symptoms Consistent with Carpal Tunnel Syndrome.”
Authors: Chen Joseph , Fowler John R 
Published: August 2022

Background:
Confirmatory methods such as nerve conduction studies (NCS) are often performed to support a clinical carpal tunnel syndrome diagnosis and to rule out other upper extremity pathologies. Ultrasonography (US) provides another diagnostic option, especially when NCS are discordant with history and physical examination. This study seeks to explore the correlation of US findings with clinical CTS diagnosis in patients with normal NCS.

Methods:
A database of 220 CTS patients was retrospectively analyzed to reveal 24 patients (28 hands) with clinically diagnosed CTS and normal NCS. Patient demographics and NCS and US findings were compared to those of a control group of non-CTS patients (42 patients, 52 hands). Median nerve cross-sectional area (CSA) was recorded, with values ≥ 10mm2 considered positive for CTS. Statistical and correlation analyses were performed between control and CTS groups comparing key parameters of interest.

Results:
Mean CSA was significantly increased in CTS patients with normal NCS than in controls. Similarly, the proportion of CTS positive, NCS negative patients with CSA measurements greater than 10mm2 was significantly greater than the proportion for control patients. Neither age nor BMI correlated with CSA measurements. NCS latencies and amplitudes did not correlate with ultrasound abnormalities.

Conclusions:
Clinically diagnosed CTS patients with normal NCS were found to have clinically significant median nerve CSA on ultrasound (10.1 ± 2.1 mm2, p<0.001). Furthermore, CSA measurements on ultrasound do not correlate with NCS parameters. These results suggest that ultrasound holds a unique diagnostic utility in the evaluation of CTS, especially when NCS are negative.
Early cleft lip repair: Demonstrating efficacy in the first 100 patients
Authors: Wlodarczyk Jordan R. , Wolfswinkel Erik M. , Liu Alice , Fahradyan Artur , Goel Pedram , Magee III William , Urata Mark M. , Hammoudeh Jeffrey A. 
Published: August 2022

Background
Cleft lip and/or palate (CL/P) affect approximately 1/700 live births. Optimal timing for repair of cleft lip has yet to be objectively validated. Earlier repair takes advantage of a high degree of plasticity within the nasal cartilage and maxilla. We present patients enrolled in an early cleft lip repair (ECLR) protocol facilitating effective repair of the cleft lip and nostril.

Methods
ASA class I/II patients with unilateral cleft lip and/or palate undergoing repair < 3 months of age were enrolled over 5 years. Perioperative data, surgical and anesthetic complications, preoperative and postoperative nostril breadth (NB), nostril width (NW), nasal angle (NA), lip length (LL), frontal nasal breadth (FNB), and commissure length (CL) measured as ratios between cleft and non-cleft sides were abstracted. ECLR and Nasoalveolar molding (NAM) patients were matched for cleft lip severity using the cleft width ratios (CWR) and compared.

Results
The surgical and anesthetic complication rate for 100 ECLR patients was 2%. Operative and anesthetic times were 123 minutes (SD 37) and 177 minutes (SD 34), respectively. Hospital length of stay was 1 day (SD 0). Age at repair between ECLR and NAM was 33 days (SD 15) and 118 days (SD 33), respectively. After ECLR, preoperative to postoperative distance from symmetry for all anthropomorphic measurements improved (p < 0.001). Comparing severity matched ECLR to NAM patients, similar improvements were observed suggesting equivalent results (p > 0.05).

Conclusions
ECLR provides an efficacious method for correcting the cleft lip and nasal deformity that simulates NAM.
“Needle Aponeurotomy for Stage IV Dupuytren’s Contracture: A Wide-Awake First Step Approach in consecutive 204 rays.”
Authors: Denkler Keith A , Park Keon Min 
Published: August 2022

Summary:
Severe forms of Dupuytren’s disease (DD) are difficult to treat and surgical fasciectomy is often the first choice even with its high complication rate. At times, amputation is recommended. The objective of our study was to evaluate the efficacy of minimally invasive needle fasciotomy (needle aponeurotomy or NA) as the first and only treatment for severely (Stage IV) Dupuytren’s contracture by performing a retrospective chart review of a single surgeon’s consecutive experience over 8 years. 204 rays in 165 patients with severe DD with total passive extension digit contracture (TPED) with ≥135° were included in the study.
Mean follow up length was 22.3 months. Standard goniometric measurements of finger joint contractures were taken before NA and at follow up visits. There was a significant improvement in TPED as well as flexion contracture at each finger joint. Pre-procedure median flexion contractures were -70° (IQR -80 to -55) at MCPJ, -75° (IQR -85 to -65) at PIPJ, and -5° (-20 to 0) at DIPJ with the median TPED of -145° (IQR -160 to -135). Post-procedure flexion contractures improved with 74% gain at MCPJ, 32% gain at PIPJ, and 46% gain at DIPJ with overall 55% gain of TPED (p<0.001). Our study shows that NA led to significant improvements in joint contractures at all finger joints with minimal adverse effects. We believe NA is an effective and safe first-line treatment for severe DD as the sole treatment or preliminary step for more invasive procedures if needed.
Can the Immediate Implantation With Immediate Loading Achieve an Acceptable Esthetic Outcome? A Prospective Observational Clinical Study
Authors: Naeem Dalya M. , Al-Jumaily Hassanien A. 
Published: August 2022

The trending protocol in implantology aims at integrating the esthetic on par with function while reducing discomfort and treatment time with optimal results. The purpose of this study was to evaluate the pink esthetic score in sites treated by graftless instant implantation that was boosted by instant provisionalization with a 2 to 3 mm jumping distance. Thirty-five implants were inserted in the extraction sockets of teeth of 29 healthy qualified patients (22 females and 7 males) with an age range of 23 to 60 years [mean±SD age 41.11±9.9 y). Preoperative assessment was complemented clinically and radiographically for each patient. The used system was Medentika dental implant (Germany). Osstell implant stability quotient was used to measure implant stability at the time of surgery (baseline) and at 16 weeks. Four implants in 3 patients failed. The implant survival rate was 88.6%. The protocol of this study produced a significant decrease in the jumping distance which is 2 to 3 mm at cone-beam computed tomography evaluation with satisfactory esthetic outcomes clinically. Further comparative studies with long-term and larger samples are needed to confirm the conclusion of this study.
The Application of Subcutaneous Radiofrequency After Liposuction for the Lower Face and Neck Contouring Under Local Anesthesia
Authors: Zhu Jingjing , Liu Tianyi , Zhou Yiqun , Guo Yu , Chen Liang 
Published: August 2022

Background:
Radiofrequency-assisted liposuction (RFAL) is a new choice in energy-assisted body-contouring techniques. The purpose of this study is to observe the clinical effect and safety of RFAL on lower face and neck contouring under local anesthesia, and different outcome compared with traditional liposuction.

Methods:
From November 2016 to November 2020, a total of 72 patients with fat accumulation and skin laxity in lower face and neck, including 42 patients underwent subcutaneous radiofrequency after liposuction (group A) and 30 patients underwent traditional liposuction only (group B). The patient’s parameters recorded involved age, sex, body mass index, the volume of fat aspirated, energy delivered, operative time, and complications. They were photographed for comparison before and after treatment. At 3 and 6 months after the operation, improvement in skin tightening and patient satisfaction was surveyed postoperatively and assessed by third-party surgeons.

Results:
At 6 months after the operation, evaluations scores of the contouring outcome had significant difference between 2 groups (3.0±0.9 versus 2.5±1.0, P=0.045). There was no significant difference at 3 months (2.8±1.0 versus 2.6±1.0, P=0.265). Although the satisfaction rate of group A was higher than that of group B both at 3 months (76.2% versus 66.7%) and 6 months (80.9% versus 60.0%), there were no significant differences in average score (P>0.05). No significant complications or adverse events requiring further medical or surgical intervention after treatment.

Conclusion:
Subcutaneous radiofrequency after Liposuction is a safe and effective treatment that can achieve significant improvement of the fat accumulation and skin laxity of the lower face and neck under local anesthesia.
Videofluoroscopy Versus Nasopharyngoscopy of Lateral Pharyngeal Wall Movement for Assessment of Velopharyngeal Insufficiency
Authors: Sullivan Stephen R. , Taylor Helena O.B. , Stiles Emily , Nuss Roger C. , Balkin Daniel M. , Mulliken John B. 
Published: August 2022

Background:
Competent speech requires closure of the velopharyngeal sphincter by dynamic apposition of the velum and posterior and lateral pharyngeal walls. An accurate estimation of lateral pharyngeal wall motion is an important determinant in the planning and the outcome of any operation to correct velopharyngeal insufficiency (VPI). The purpose was to compare the assessment of lateral pharyngeal wall movement by videofluoroscopy (VP) versus nasopharyngoscopy (NP).

Methods:
The authors retrospectively reviewed the charts of 269 consecutive patients in our cleft lip/palate clinic from 1982 to 2008 and culled those treated with a pharyngeal flap for VPI. The authors included patients who were evaluated preoperatively by both VP and NP, and had studies of suitable quality. Percentage of lateral pharyngeal wall motion was estimated with each technique and compared for each patient.

Results:
The authors identified 25 patients who underwent both VP and NP at the same median age (4.7 years). The estimated percentage of lateral pharyngeal wall motion between the 2 techniques was significantly different (P<0.001). Average lateral pharyngeal wall motion was estimated to be 59±25% (range: 5%–90%) by VP and only 40%±25% (range: 0%–95%) during NP.

Conclusions:
VP and NP are complementary, but assessment of lateral pharyngeal wall motion can vary between the 2 methods. The surgeon should be aware of the difference in estimated lateral pharyngeal wall movement when planning a procedure to correct VPI.