bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibody response to a third SARS‐CoV‐2 vaccine dose in recipients of an allogeneic haematopoietic cell transplantation
Authors: Bankova Andriyana K. , Pasin Chloé , Huang Alice , Cicin‐Sain Caroline , Epp Selina , Audige Annette , Mueller Nicolas J. , Nilsson Jakob , Vilinovszki Oliver , Nair Gayathri , Wolfensberger Nathan , Hockl Philipp , Schanz Urs , Trkola Alexandra , Kouyos Roger , Hasse Barbara , Zinkernagel Annelies S. , Manz Markus G. , Abela Irene A. , Müller Antonia M. S. 
Published: November 2022

SummaryAllogeneic haematopoietic cell transplantation (allo‐HCT) recipients show impaired antibody (Ab) response to a standard two‐dose vaccination against severe acute respiratory syndrome coronavirus‐2 and currently a third dose is recommended as part of the primary vaccination regimen. By assessing Ab titres 1 month after a third mRNA vaccine dose in 74 allo‐HCT recipients we show sufficient neutralisation activity in 77% of the patients. Discontinuation of immunosuppression before the third vaccine led to serological responses in 50% of low responders to two vaccinations. Identifying factors that might contribute to better vaccine responses in allo‐HCT recipients is critical to optimise current vaccination strategies.
Nestin expression in osteocytes following myeloablation and during bone marrow metastasis
Authors: Koerber Ruth‐Miriam , Schneider Rebekka K. , Pritchard Jessica Ellen , Teichmann Lino L. , Schumacher Udo , Brossart Peter , Gütgemann Ines 
Published: November 2022

SummaryNestin is an intermediate filament protein, which was originally detected in neuroepithelial stem cells. Besides its use as a phenotypic marker of mesenchymal stem cells in the hematopoeitic stem cell niche, the functional interpretation of nestin+ cells remains elusive. We investigated the cellular expression of nestin in bone marrow trephine biopsies of MPN patients, following myeloablation at a stage of hypocellularity during early regeneration. Here, nestin is highly expressed in mature osteocytes, arteriolar endothelial and perivascular cells and small capillaries within the bone marrow space, but not in sinusoid lining cells. This is in stark contrast to nestin expression pattern in myeloproliferative neoplasms that show hypercellularity due to oncogenic driver mutations. Here, nestin is expressed exclusively in endothelial cells of arterioles, but not in osteocytes or small capillaries. Thus, the pattern of nestin expression following myeloablation inversely correlates with cellularity in the bone marrow. This nestin expression pattern is mimicking early postnatal transcriptional programming during bone marrow development. We show that nestin expression in osteocytes occurs across different species following transplant and also in bone marrow metastasis.
Stealth democracy and the school board trustee
Authors: Piscitelli Anthony , Perrella Andrea 
Published: November 2022

AbstractThe value of elected school board trustees has been a topic of debate. Several provinces in Canada have already eliminated them, with Manitoba currently considering abolishing them as well. Whether this is supported—or opposed—by the public is somewhat unknown. This research note reports the results of a survey of Ontario residents. We find that while two‐thirds of respondents support retaining trustees, there are factors that pull people more towards favouring their elimination. Support for trustees is significantly lower for males, younger respondents, and those on the political right.
Methyltransferase‐like 3 promotes cervical cancer metastasis by enhancing cathepsin L mRNA stability in an N6‐methyladenosine‐dependent manner
Authors: Liu Pingping , Ju Mingxiu , Zheng Xiaojing , Jiang Yinan , Yu Xingjuan , Pan Baoyue , Luo Rongzhen , Jia Weihua , Zheng Min 
Published: November 2022

AbstractN6‐methyladenosine (m6A) is a highly abundant RNA modification in eukaryotic cells. Methyltransferase‐like 3 (METTL3), a major protein in the m6A methyltransferase complex, plays important roles in many malignancies, but its role in cervical cancer metastasis remains uncertain. Here, we found that METTL3 was significantly upregulated in cervical cancer tissue, and its upregulation was associated with a poor prognosis in cervical cancer patients. Knockdown of METTL3 significantly reduced cervical cancer cell migration and invasion. Conversely, METTL3 overexpression markedly promoted cervical cancer cell metastasis in vitro and in vivo. Furthermore, METTL3 mediated the m6A modification of cathepsin L (CTSL) mRNA at the 5′‐UTR, and the m6A reader protein insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2) bound to the m6A sites and enhanced CTSL mRNA stability. Our results indicated that METTL3 enhanced CTSL mRNA stability through an m6A‐IGF2BP2‐dependent mechanism, thereby promoting cervical cancer cell metastasis. These findings provide insights into a novel m6A modification pattern involved in cervical cancer development.
Improved Evaluation and Generation Of Grid Layouts Using Distance Preservation Quality and Linear Assignment Sorting
Authors: Barthel K. U. , Hezel N. , Jung K. , Schall K. 
Published: November 2022

AbstractImages sorted by similarity enables more images to be viewed simultaneously, and can be very useful for stock photo agencies or e‐commerce applications. Visually sorted grid layouts attempt to arrange images so that their proximity on the grid corresponds as closely as possible to their similarity. Various metrics exist for evaluating such arrangements, but there is low experimental evidence on correlation between human perceived quality and metric value. We propose distance preservation quality (DPQ) as a new metric to evaluate the quality of an arrangement. Extensive user testing revealed stronger correlation of DPQ with user‐perceived quality and performance in image retrieval tasks compared to other metrics. In addition, we introduce Fast linear assignment sorting (FLAS) as a new algorithm for creating visually sorted grid layouts. FLAS achieves very good sorting qualities while improving run time and computational resources.
Characteristics and difference of respiratory diseases in Korean adults aged ≥40 years: A cross‐sectional study
Authors: Won Yoon Jae , Lee Sook‐Hyun , Lim Yu‐Cheol , Lee Yoon Jae , Van den Noort Maurits , Lee Beom‐Joon , Ha In‐Hyuk 
Published: November 2022

AbstractPurposeNational big data pertaining to the status of common respiratory diseases is essential to devising appropriate policies to promote proper treatment and prevention of respiratory diseases amid the prolonged coronavirus disease 2019 (COVID‐19) pandemic. The aim of this study is to investigate the prevalence of common respiratory diseases and their association with sociodemographic characteristics, comorbidities, and medical history using 11 years (2008–2018) of the Korea National Health and Nutrition Examination Survey (KNHANES) data, ultimately to present foundational data for policy decision making and disease prevention measures.MethodsAmong the participants of the KNHANES survey (2008–2018), 93 028 adults aged ≥40 years who underwent a lung function test were included in this cross‐sectional study. The participants were divided into four groups: Asthma, chronic obstructive pulmonary disease (COPD), asthma + COPD, and no respiratory disease. Their data were analyzed for demographic factors, health behavior, and disease‐related factors. Multiple logistic regression was used to calculate the odds ratio (OR) adjusted for sex, age, household income, educational level, occupation, body mass index (BMI), smoking status, alcohol consumption, physical activity, and comorbidities.ResultsOf all participants, 1.83%, 12.63%, and 1.27% had only asthma, only COPD, and asthma + COPD, respectively. With respect to the patients with asthma who also had asthma + COPD, the OR of asthma + COPD was 5.272 in underweight patients and 6.479 in patients aged ≥70 years. Meanwhile, a high association between COPD and asthma + COPD was found in female patients, whereas asthma was more highly associated with asthma + COPD in male patients.ConclusionThe study confirmed that old age, sex, smoking status, BMI, previous history of atopic dermatitis, and lung cancer were independent risk factors for asthma, COPD, and asthma + COPD. The present study demonstrated the need for a multidisciplinary integrative approach to respiratory diseases, and the findings could be used for developing policies for the treatment of COVID‐19 and respiratory diseases and the prevention of infectious diseases.
Perioperative mortality in liver transplantation before and after the implementation of the organ allocation policy Share 35
Authors: Holm Zacharias D. , Kolodzie Kerstin , Galli Alessandro M. , Meyhoff Christian S. , Niemann Claus U. , Adelmann Dieter 
Published: November 2022

AbstractIntroductionIn 2013, a new liver transplant allocation policy (Share 35) aimed to reduce waitlist‐mortality was introduced in the United States. Regional organ sharing for recipients with a MELD score of ≥35 was prioritized over local allocation to those with lower MELD scores. Our aim was to assess the changes in perioperative mortality following the introduction of Share 35 as well as changes in patients’ short‐term 7‐day survival, patients discharged alive and 1‐year survival. Analyses were also carried out for the subgroups of patients with MELD scores ≥ and < 35.MethodsWe used data from the Scientific Registry of Transplant Recipients and included liver transplants between March 2002 and December 2018 in this retrospective cohort study. Perioperative mortality was defined as death during and within two days of liver transplant. We used robust interrupted time series analyses to evaluate the impact of Share 35 on mortality.ResultsWe included 90 002 liver transplants in our analysis and observed a decreasing trend in perioperative mortality over time (−.061 deaths per 1000 cases per month, 95% CI −.084 to −.037, p < .001). Share 35 was not associated with a change in perioperative mortality (p = .33), short‐term 7‐day survival (p = .48), survival to discharge (p = .56), or 1‐year survival (p = .27).ConclusionsPrioritizing sicker recipients with a MELD score ≥35 for liver transplantation was not associated with a change in postoperative mortality.
Test–retest reliability of a finger‐tapping fMRI task in a healthy population
Authors: Wüthrich Florian , Lefebvre Stephanie , Nadesalingam Niluja , Bernard Jessica A. , Mittal Vijay A. , Shankman Stewart A. , Walther Sebastian 
Published: November 2022

AbstractMeasuring brain activity during functional MRI (fMRI) tasks is one of the main tools to identify brain biomarkers of disease or neural substrates associated with specific symptoms. However, identifying correct biomarkers relies on reliable measures. Recently, poor reliability was reported for task‐based fMRI measures. The present study aimed to demonstrate the reliability of a finger‐tapping fMRI task across two sessions in healthy participants. Thirty‐one right‐handed healthy participants aged 18–60 years took part in two MRI sessions 3 weeks apart during which we acquired finger‐tapping task‐fMRI. We examined the overlap of activations between sessions using Dice similarity coefficients, assessing their location and extent. Then, we compared amplitudes calculating intraclass correlation coefficients (ICCs) in three sets of regions of interest (ROIs) in the motor network: literature‐based ROIs (10‐mm‐radius spheres centred on peaks of an activation likelihood estimation), anatomical ROIs (regions as defined in an atlas) and ROIs based on conjunction analyses (superthreshold voxels in both sessions). Finger tapping consistently activated expected regions, for example, left primary sensorimotor cortices, premotor area and right cerebellum. We found good‐to‐excellent overlap of activations for most contrasts (Dice coefficients: .54–.82). Across time, ICCs showed large variability in all ROI sets (.04–.91). However, ICCs in most ROIs indicated fair‐to‐good reliability (mean = .52). The least specific contrast consistently yielded the best reliability. Overall, the finger‐tapping task showed good spatial overlap and fair reliability of amplitudes on group level. Although caution is warranted in interpreting correlations of activations with other variables, identification of activated regions in response to a task and their between‐group comparisons are still valid and important modes of analysis in neuroimaging to find population tendencies and differences.
Actin related protein 2/3 complex subunit 1 up‐regulation in the hypothalamus prevents high‐fat diet induced obesity
Authors: Ni Weimin , Zhang Jie , Wang Bing , Liang Feng , Bao Long , Li Pengfei , Fang Yan 
Published: November 2022

AbstractObesity is a major health crisis in the modern society. Studies have shown that the consumption of a high‐fat diet (HFD) induces hypothalamic inflammation and leptin resistance, which consequently favours body mass gain. Actin related protein 2/3 complex subunit 1 (ARPC1B), an actin‐binding protein, is highly expressed in immune cells. Recent studies have shown that ARPC1B has a certain anti‐inflammatory effect. While ARPC1B expression is decreased in the hypothalamus of mice fed a HFD, the role of ARPC1B in HFD‐induced obesity remains unclear. Thus, we investigated whether ARPC1B up‐regulation in the hypothalamic arcuate nucleus (ARC) could inhibit the development of obesity. Herein, ARPC1B overexpression lentiviral particles were stereotaxically injected into the ARC of male C57BL/6J mice (7 weeks old) fed with HFD. Overexpression of ARPC1B in the hypothalamic ARC attenuated HFD‐induced ARC inflammation, reduced body‐weight gain and feed efficiency. Furthermore, up‐regulation of ARC ARPC1B improved the glucose tolerance and reduced subcutaneous/epididymal fat mass accumulation, which decreased the serum total cholesterol, serum triglyceride and leptin levels. In addition, upon ARPC1B overexpression in the hypothalamic ARC, intraperitoneal injection of leptin increased the phosphorylation level of signal transducer and activator of transcription 3 (STAT3), an important transcription factor for leptin's action, in the ARC of obese mice. Accordingly, we suggest that up‐regulation of ARPC1B in the hypothalamic ARC may improve the HFD‐induced hypothalamic inflammation and leptin resistance. Our findings demonstrate that ARPC1B is a promising target for the treatment of diet‐induced obesity.
Adoptive cell transfer therapy for melanoma
Authors: Inozume Takashi 
Published: November 2022

AbstractAdoptive cell transfer (ACT) of tumor‐infiltrating lymphocytes (TILs) for melanoma is an example of the most successful cancer immune therapy. It achieves a durable complete response about ~20% of patients, and they might be cured. However, the ratio of patients with durable benefits is not high, and its complicated procedure prevents its diffusion. Therefore, many efforts to enhance the effect and simplify the protocol of TIL therapy have been made so far, resulting in the establishment of a simple and effective current TIL therapy that has been propagated to other institutes and countries. Moreover, TIL therapy and translational research using clinical samples derived from durable responders elucidate the important element for developing more effective cancer immune therapies in the future. This review introduced the brief history, attempts for the improvement and important findings elucidated by translational research of ACT for melanoma.
The impact of exchange listing on corporate governance: Evidence from direct listings
Authors: French Dan W. , Morillon Thibaut G. , Yore Adam S. , Kern Andrew E. 
Published: November 2022

AbstractWe use prior direct listings by public nonlisted REITs (PNLRs) to explore the impact of exchange membership on corporate governance. We study companies with public, but nonlisted shares in a unique setting where the influence of listing is distinct from the confounding effect of capital raising. Evidence suggests younger, more profitable companies with stronger governance and professional management are more likely to directly list. Institutional ownership increases after listing and these changes are not due to future capital raising. Moreover, internal corporate governance improves beyond the exchange's requirements, especially for those companies with greater stock liquidity and more institutional ownership.
One patient, two malpositioned hemodialysis catheters, (hepatic vein and ascending lumbar vein), no fluoroscopy
Authors: Çelik Ersin , Çora Ahmet Rıfkı 
Published: November 2022

AbstractCuffed‐tunneled hemodialysis catheter (CTHC) application via the femoral vein is a safe and effective alternative when peripheral vascular routes are exhausted for hemodialysis in patients with end‐stage renal disease. Also, imaging methods have become more important for the diagnosis or prevention of the possible complications that may develop during or after catheter placements. Here, we present a case of hemodialysis catheter dysfunction due to the insertion of a CTHC tip into the hepatic vein, and into the left ascending lumbar vein at the next attempt. We think that the use of fluoroscopy, whether in the first catheter intervention or catheter change, is extremely important in preventing possible complications that may develop, or detecting them as soon as possible.
Quality of life measurement tools for people with dementia and intellectual disabilities: A systematic review
Authors: Tsang Winnie , Oliver David , Triantafyllopoulou Paraskevi 
Published: November 2022

AbstractBackgroundAdults with intellectual disabilities are an at‐risk group of developing dementia. In the absence of a cure for dementia, emphasis on treatment is the promotion of Quality of life (QoL). The aim of this review is to identify and describe QoL tools for people with intellectual disabilities and dementia.MethodA systematic review was carried out using 10 databases and papers from up to March year 2021.ResultsTwo instruments were identified and examined. The QoL in late‐stage dementia, which showed evidence of good levels of internal consistency, intra‐rater reliability, test–retest reliability, and convergent validity. The Dementia Quality of Life – proxy was also used; however, its psychometric properties have yet to be studied within the intellectual disabilities population.ConclusionIt is recommended instruments should be developed and psychometrically tested specifically for adults with intellectual disabilities and dementia to help inform policy makers, measure outcomes of interventions and personal outcomes.
Impact of COVID‐19 restrictions on the postpartum experience of women living in Eastern Canada during the early pandemic period: A cross‐sectional study
Authors: Dol Justine , Hughes Brianna , Aston Megan , McMillan Douglas , Tomblin Murphy Gail , Campbell‐Yeo Marsha 
Published: November 2022

AbstractObjectivesTo (1) compare changes in parenting self‐efficacy, social support, postpartum anxiety, and postpartum depression in Canadian women before and during the early COVID‐19 pandemic; (2) explore how women with a newborn felt during the pandemic; (3) explore ways that women coped with challenges faced.MethodsA cross‐sectional design was used. Prior to the pandemic, an online survey was conducted with women who an infant 6 months old or less in one of the three Eastern Canadian Maritime provinces. A similar survey was conducted during the pandemic in mid‐2020.ResultsPre‐COVID, 561 women completed the survey, and 331 women during the pandemic. There were no significant differences in parenting self‐efficacy, social support, postpartum anxiety, and depression between the cohorts. Difficulties that women reported because of COVID‐19 restrictions included lack of support from family and friends, fear of COVID‐19 exposure, feeling isolated and uncertain, negative impact on perinatal care experience, and hospital restrictions. Having support from partners and families, in‐person/virtual support, as well as engaging in self‐care and the low prevalence of COVID‐19 during the summer of 2020 helped women cope.Clinical relevanceWomen identified challenges and negative impacts due to the COVID‐19 pandemic, although no differences in psychosocial outcomes were found. Consideration of public health policy during the postpartum period for the ongoing COVID‐19 pandemic is needed.ConclusionWhile there were no significant differences in psychosocial outcomes, there were still challenges and negative impacts that women identified.
Generalizing Knowledge of Second Language Collocations: The Roles of Within‐ and Cross‐Language Similarity on Acceptability and Event‐Related Potentials
Authors: Pulido Manuel F. 
Published: November 2022

AbstractRecent research has shown that knowledge of second language (L2) collocations is important to learners for improving their language processing and production but also that acquiring L2‐specific collocations is a very burdensome task for learners. Thus, bootstrapping knowledge of L2 collocations through generalization is highly desirable, but this area has received surprisingly limited attention. This study examined L2 learners’ ability to generalize knowledge of recently learned verb–noun collocations during processing and whether this type of learning occurred via intralexical associations in the L2 (similarity) or was facilitated by known collocations in learners’ first language (L1). Mixed‐effects regression targeting measures of learners’ brain event‐related potentials revealed cross‐language influence during real‐time processing that preceded learners’ acceptability judgments. Both within‐ and cross‐language similarity influenced learners’ behavioral judgments. These findings revealed cross‐language integration in L1–L2 incongruent collocations from the earliest moments of processing.
Familial Deaths and First Birth
Authors: Rackin Heather M. , Gibson‐Davis Christina M. 
Published: November 2022

AbstractMotivated by the rise in premature mortality among working‐age adults, we examine the association between adult familial deaths and the transition to motherhood. Although many deaths can be disruptive, deaths that occur sooner than expected and to certain family members (e.g., mothers) may prompt changes in resources, time available for parenting, or psychological understandings in ways that change fertility behavior. Data come from the National Longitudinal Survey of Youth 1997 (N = 4,008 women aged 15–34). Using fixed effects to address selection, we compare the associations between recent off‐time deaths (mother, father, or sibling deaths) and on‐time deaths (grandparent deaths) on fertility. Women had higher odds of first birth when they recently experienced a sibling or maternal death compared to when they had not recently experienced that type of death. Effects of maternal and sibling deaths were statistically larger than the null effect found for grandparent death. The strong effect of sibling and maternal death on hastening first birth suggest that mortality may influence a psychological reevaluation of values vis‐à‐vis parenting and/or decrease psychological well‐being in ways that change sexual practices.