bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between emotional regulation and hemispheric lateralization in depression: a systematic review and a meta-analysis
Authors: Horato Natia , Quagliato Laiana A. , Nardi Antonio E. 
Published: April 2022

AbstractFrom a neurobiological perspective, diverse studies have associated emotional regulation with cognitive deficits. Structural and/or metabolic changes in the frontal cortex are often inferred from dysfunction in cognitive-emotional processing. In addition, electroencephalographic findings support the idea that alpha band oscillations are responses to these same processes. Thus, the objective of this meta-analytical literature review is to verify whether the possible hemispheric lateralization attributed to frontal alpha asymmetry (FAA) correlates with emotional regulation and the cognitive deficits underlying depression. The data included in our meta-analysis are from articles published from 2009 to July 2020, which utilized DSM or ICD criteria to diagnose depression or anxiety disorders and included a control group. For statistical analysis, the measurements obtained through the 10–20 electroencephalography system were used. The frontal alpha asymmetry index was calculated from the difference between the logarithm of the absolute spectral values in the alpha rhythm observed from the F4 and F3 electrodes that were fixed to the scalp of the frontal region of the right and left hemispheres (ln µV² RH−ln µV² LH) = (F4−F3). Eighteen articles were included in the systematic review. Of these, 9 were homogeneous enough for statistical analyses (total N: 1061; NDep: 326; Ncont: 735). Nine others could not be statistically analyzed due to the absence of FAA measurements from the F4 and F3 electrodes. A random effects meta-analysis revealed low heterogeneity (Qt = 11,00, df = 8, p = 0.20, I2 = 27%) and an average effect size of the studies equal to −0.03 (CI = [−0.07 to 0.01]). The results, although not significant, suggested a slight tendency toward left lateralization in the depression group. Although the effects shown in these data did not confirm hemispherical lateralization in depressed patients, it was found that emotional regulation and cognitive processes share similar neural circuits. Therefore, future research on this complex relationship is encouraged, especially studies that are focused on the search for quantitative biological markers in depression.
Interaction between macrophages and ferroptosis
Authors: Yang Yan , Wang Yu , Guo Lin , Gao Wen , Tang Ting-Li , Yan Miao 
Published: April 2022

Abstract
Ferroptosis, a newly discovered iron-dependent cell death pathway, is characterized by lipid peroxidation and GSH depletion mediated by iron metabolism and is morphologically, biologically and genetically different from other programmed cell deaths. Besides, ferroptosis is usually found accompanied by inflammatory reactions. So far, it has been found participating in the development of many kinds of diseases. Macrophages are a group of immune cells that widely exist in our body for host defense and play an important role in tissue homeostasis by mediating inflammation and regulating iron, lipid and amino acid metabolisms through their unique functions like phagocytosis and efferocytosis, cytokines secretion and ROS production under different polarization. According to these common points in ferroptosis characteristics and macrophages functions, it’s obvious that there must be relationship between macrophages and ferroptosis. Therefore, our review aims at revealing the interaction between macrophages and ferroptosis concerning three metabolisms and integrating the application of certain relationship in curing diseases, mostly cancer. Finally, we also provide inspirations for further studies in therapy for some diseases by targeting certain resident macrophages in distinct tissues to regulate ferroptosis.

Facts

Ferroptosis is considered as a newly discovered form characterized by its nonapoptotic and iron-dependent lipid hydroperoxide, concerning iron, lipid and amino acid metabolisms.

Ferroptosis has been widely found playing a crucial part in various diseases, including hepatic diseases, neurological diseases, cancer, etc.

Macrophages are phagocytic immune cells, widely existing and owning various functions such as phagocytosis and efferocytosis, cytokines secretion and ROS production.

Macrophages are proved to participate in mediating metabolisms and initiating immune reactions to maintain balance in our body.

Recent studies try to treat cancer by altering macrophages’ polarization which damages tumor microenvironment and induces ferroptosis of cancer cells.

Open questions

How do macrophages regulate ferroptosis of other tissue cells specifically?

Can we use the interaction between macrophages and ferroptosis in treating diseases other than cancer?

What can we do to treat diseases related to ferroptosis by targeting macrophages?

Is the use of the relationship between macrophages and ferroptosis more effective than other therapies when treating diseases?
Maternal personality and postpartum mental disorders in Japan: the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study
Authors: Murakami Keiko , Ishikuro Mami , Obara Taku , Ueno Fumihiko , Noda Aoi , Onuma Tomomi , Matsuzaki Fumiko , Kikuchi Saya , Kobayashi Natsuko , Hamada Hirotaka , Iwama Noriyuki , Metoki Hirohito , Saito Masatoshi , Sugawara Junichi , Tomita Hiroaki , Yaegashi Nobuo , Kuriyama Shinichi 
Published: April 2022

AbstractPersonality has been shown to predict postpartum depressive symptoms (PDS) assessed by the Edinburgh Postnatal Depression Scale (EPDS). However, existing studies have not considered the underlying symptom dimensions in the EPDS. We analyzed data from 15,012 women who participated in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Personality was assessed in middle pregnancy using the short-form Eysenck Personality Questionnaire-Revised. PDS were defined as EPDS score ≥ 9 at 1 month after delivery. The EPDS items were further divided into three dimensions: depressed mood, anxiety, and anhedonia. Multiple analyses were conducted to examine the associations of each personality scale with PDS and three dimensions in the EPDS, adjusting for age, parity, mode of delivery, education, income, and social isolation. The prevalence of PDS assessed by the EPDS at 1 month after delivery was 13.1%. Higher neuroticism scores were associated with PDS (odds ratio [OR], 2.63; 95% confidence interval [CI], 2.48 to 2.79) and all three dimensions (all p < 0.001). Lower extraversion scores were associated with PDS (OR, 0.74; 95% CI, 0.70 to 0.78) and all three dimensions (all p < 0.001). Lower psychoticism scores were associated with PDS (OR, 0.89; 95% CI, 0.85 to 0.94) and anxiety (p < 0.001), but not with depressed mood (p = 0.20) or anhedonia (p = 0.92). In conclusion, higher neuroticism and lower extraversion were associated with PDS and the three underlying dimensions in the EPDS, while lower psychoticism was associated with anxiety, but not with depressed mood or anhedonia.
Texture evolution during processing and post-processing of maraging steel fabricated by laser powder bed fusion
Authors: Kannan Rangasayee , Nandwana Peeyush 
Published: April 2022

AbstractIn this study, the evolution of solidification texture during LPBF of Ti-free grade 300 maraging steel, and its effect on texture development during subsequent post-fabrication heat treatments was characterized using Electron Backscatter Diffraction (EBSD). It was found that in the as-fabricated state, no texture was observed in the room temperature martensitic phase. However, the reconstructed parent austenite phase displayed a Cube texture with a minor fraction of Rotated Goss texture. During subsequent aging treatments involving two different routes, namely direct aging of the as-fabricated samples, and conventional solution treatment + aging of the as-fabricated samples, significant changes in the texture components of parent austenite were observed, whereas no changes in texture were observed in the room temperature martensitic phase. During direct aging, it was found that with an increase in the aging temperature up to 520 °C, the texture components of the parent austenite changed from Cube/Rotated Goss to Brass, whereas during the conventional solution treatment and aging cycle, interestingly a change in texture component to rotated copper was observed. The transitions in texture components have been discussed using the concepts of recrystallization and twinning in austenite during annealing and/or aging, and strain energy release maximization (SERM) theory. Furthermore, the importance of these preferred orientations on the mechanical properties was quantified using transformation potential diagrams.
Deep 3D attention CLSTM U-Net based automated liver segmentation and volumetry for the liver transplantation in abdominal CT volumes
Authors: Jeong Jin Gyo , Choi Sangtae , Kim Young Jae , Lee Won-Suk , Kim Kwang Gi 
Published: April 2022

AbstractIn living-donor liver transplantation, the safety of the donor is critical. In addition, accurately measuring the liver volume is significant as the amount that can be resected from living donors is limited. In this paper, we propose an automated segmentation and volume estimation method for the liver in computed tomography imaging based on a deep learning-based segmentation network. Our framework was trained using the data of 191 donors, achieved a dice similarity coefficient of 0.789, 0.869, 0.955, and 0.899, respectively, in the segmentation task for the left lobe, right lobe, caudate lobe, and whole liver. Moreover, the R^2 score reached 0.980, 0.996, 0.953, and 0.996 in the volume estimation task. We demonstrate that our approach provides accurate and quantitative liver segmentation results, reducing the error in liver volume estimation. Therefore, we expected to be used as an aid in estimating liver volume from CT volume data for living-donor liver transplantation.
Theoretical modeling of dendrite growth from conductive wire electro-polymerization
Authors: Kumar Ankush , Janzakova Kamila , Coffinier Yannick , Pecqueur Sébastien , Alibart Fabien 
Published: April 2022

AbstractElectropolymerization is a bottom-up materials engineering process of micro/nano-scale that utilizes electrical signals to deposit conducting dendrites morphologies by a redox reaction in the liquid phase. It resembles synaptogenesis in the brain, in which the electrical stimulation in the brain causes the formation of synapses from the cellular neural composites. The strategy has been recently explored for neuromorphic engineering by establishing link between the electrical signals and the dendrites’ shapes. Since the geometry of these structures determines their electrochemical properties, understanding the mechanisms that regulate polymer assembly under electrically programmed conditions is an important aspect. In this manuscript, we simulate this phenomenon using mesoscale simulations, taking into account the important features of spatial–temporal potential mapping based on the time-varying signal, the motion of charged particles in the liquid due to the electric field, and the attachment of particles on the electrode. The study helps in visualizing the motion of the charged particles in different electrical conditions, which is not possible to probe experimentally. Consistent with the experiments, the higher AC frequency of electrical activities favors linear wire-like growth, while lower frequency leads to more dense and fractal dendrites’ growth, and voltage offset leads to asymmetrical growth. We find that dendrites' shape and growth process systematically depend on particle concentration and random scattering. We discover that the different dendrites’ architectures are associated with different Laplace and diffusion fields, which govern the monomers’ trajectory and subsequent dendrites’ growth. Such unconventional engineering routes could have a variety of applications from neuromorphic engineering to bottom-up computing strategies.
Black-necked spitting cobra (Naja nigricollis) phospholipases A2 may cause Trypanosoma brucei death by blocking endocytosis through the flagellar pocket
Authors: Martos-Esteban Andrea , Macleod Olivia J. S. , Maudlin Isabella , Kalogeropoulos Konstantinos , Jürgensen Jonas A. , Carrington Mark , Laustsen Andreas H. 
Published: April 2022

AbstractAfrican trypanosomes, such as Trypanosoma brucei, are flagellated protozoa which proliferate in mammals and cause a variety of diseases in people and animals. In a mammalian host, the external face of the African trypanosome plasma membrane is covered by a densely packed coat formed of variant surface glycoprotein (VSG), which counteracts the host's adaptive immune response by antigenic variation. The VSG is attached to the external face of the plasma membrane by covalent attachment of the C-terminus to glycosylphosphatidylinositol. As the trypanosome grows, newly synthesised VSG is added to the plasma membrane by vesicle fusion to the flagellar pocket, the sole location of exo- and endocytosis. Snake venoms contain dozens of components, including proteases and phospholipases A2. Here, we investigated the effect of Naja nigricollis venom on T. brucei with the aim of describing the response of the trypanosome to hydrolytic attack on the VSG. We found no evidence for VSG hydrolysis, however, N. nigricollis venom caused: (i) an enlargement of the flagellar pocket, (ii) the Rab11 positive endosomal compartments to adopt an abnormal dispersed localisation, and (iii) cell cycle arrest prior to cytokinesis. Our results indicate that a single protein family, the phospholipases A2 present in N. nigricollis venom, may be necessary and sufficient for the effects. This study provides new molecular insight into T. brucei biology and possibly describes mechanisms that could be exploited for T. brucei targeting.
Modelling epidemic spread in cities using public transportation as a proxy for generalized mobility trends
Authors: Malik Omar , Gong Bowen , Moussawi Alaa , Korniss Gyorgy , Szymanski Boleslaw K. 
Published: April 2022

AbstractWe study how public transportation data can inform the modeling of the spread of infectious diseases based on SIR dynamics. We present a model where public transportation data is used as an indicator of broader mobility patterns within a city, including the use of private transportation, walking etc. The mobility parameter derived from this data is used to model the infection rate. As a test case, we study the impact of the usage of the New York City subway on the spread of COVID-19 within the city during 2020. We show that utilizing subway transport data as an indicator of the general mobility trends within the city, and therefore as an indicator of the effective infection rate, improves the quality of forecasting COVID-19 spread in New York City. Our model predicts the two peaks in the spread of COVID-19 cases in NYC in 2020, unlike a standard SIR model that misses the second peak entirely.
Self-reported total sitting time on a non-working day is associated with blunted flow-mediated vasodilation and blunted nitroglycerine-induced vasodilation
Authors: Yamaji Takayuki , Harada Takahiro , Hashimoto Yu , Nakano Yukiko , Kajikawa Masato , Yoshimura Kenichi , Chayama Kazuaki , Goto Chikara , Han Yiming , Mizobuchi Aya , Yusoff Farina Mohamad , Kishimoto Shinji , Maruhashi Tatsuya , Nakashima Ayumu , Higashi Yukihito 
Published: April 2022

AbstractWe divided the 466 subjects into two groups based on information on sitting time on a non-working day and evaluated flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID). FMD was smaller in subjects with sitting time on a non-working day of ≥6 h/day than in subjects with sitting time on a non-working day of <6 h/day (2.5 ± 2.6% vs. 3.7 ± 2.9%; p < 0.001). NID was smaller in subjects with sitting time at non-working day of ≥ 8 h/day than in subjects with sitting time on a non-working day of < 8 h/day (10.1 ± 5.6% vs. 11.5 ± 5.0%; p = 0.01). After adjustment for confounding factors for vascular function, the odds of having the lowest tertile of FMD was significantly higher in subjects with sitting time on a non-working day of ≥6 h/day than in subjects with sitting time on a non-working day of <6 h/day. The odds of having the lowest tertile of NID was significant higher in subjects with sitting time on a non-working day of ≥ 8 h/day than in subjects with sitting time on a non-working day of < 8 h/day. These findings suggest that prolonged sitting time on a non-working day is associated with blunted FMD and blunted NID.
A comprehensive analysis of excess depressive disorder in women and men living with HIV in France compared to the general population
Authors: Hémar Victor , Hessamfar Mojgan , Neau Didier , Vareil Marc-Olivier , Rouanes Nicolas , Lazaro Estibaliz , Duffau Pierre , Cazanave Charles , Rispal Patrick , Gaborieau Valérie , Leleux Olivier , Wittkop Linda , Bonnet Fabrice , Barger Diana 
Published: April 2022

AbstractWe aimed to estimate the prevalence of depressive disorder in people living with HIV (PLWH) and evaluate its association with non-HIV-specific and HIV-specific factors in PLWH and in PLWH compared to the general population (GP). We used cross-sectional data from the QuAliV study, conducted within the ANRS-CO3 Aquitaine-AQUIVIH-NA cohort of PLWH in Nouvelle-Aquitaine (2018–2020), and a nationally-representative survey in the GP (EHIS-ESPS, 2014–2015), we included all participants aged ≥ 18 years old who had completed the Patient Health Questionnaire-8 (PHQ-8). Depressive disorder was defined as Patient Health Questionnaire-8 score greater or equal to 10. Its association with non-HIV-specific (demographic, socio-economic, behavioral, health status), HIV-specific factors (immuno-viral markers, antiretrovirals, level of perceived HIV-stigma), and HIV-status was assessed using Poisson regression models with robust variance in women and men separately. We included 914 PLWH (683 men/231 women). More than one in five PLWH had depressive disorder. It was strongly associated with being younger and experiencing severe pain in both sexes. Unemployment in women, being single, and lack of family ties in men were also associated with depressive disorder. More than 30% of our sample reported HIV-stigma, with a dose–response relationship between level of perceived HIV-stigma and depressive disorder. The crude prevalence of depressive disorder was 2.49 (95%CI 1.92–3.22) and 4.20 (95%CI 3.48–5.05) times higher in women and men living with HIV respectively compared to GP counterparts and 1.46 (95%CI 1.09–1.95) and 2.45 (95%CI 1.93–3.09) times higher after adjustment for non-HIV specific factors. The adjusted prevalence ratio of depressive disorder was not significantly different in HIV-stigma free women, but remained twice as high in HIV-stigma free men. The prevalence of depressive disorder compared to the GP tended to decrease with age in PLWH. Excess depressive disorder remains a major concern in PLWH. Our findings reaffirm the importance of regular screening. Tackling social inequalities and HIV-stigma should be prioritized to ensure that PLWH achieve good mental as well as physical health outcomes.
Local neural-network-weighted models for occurrence and number of down wood in natural forest ecosystem
Authors: Sun Yuman , Jia Weiwei , Zhu Wancai , Zhang Xiaoyong , Saidahemaiti Subati , Hu Tao , Guo Haotian 
Published: April 2022

AbstractThe natural forest ecosystem has been affected by wind storms for years, which have caused several down wood (DW) and dramatically modified the fabric and size. Therefore, it is very important to explain the forest system by quantifying the spatial relationship between DW and environmental parameters. However, the spatial non-stationary characteristics caused by the terrain and stand environmental changes with distinct gradients may lead to an incomplete description of DW, the local neural-network-weighted models of geographically neural-network-weighted (GNNWR) models are introduced here. To verify the validity of models, our DW and environmental factors were applied to investigate of occurrence of DW and number of DW to establish the generalized linear (logistic and Poisson) models, geographically weighted regression (GWLR and GWPR) models and GNNWR (GNNWLR and GNNWPR) models. The results show that the GNNWR models show great advantages in the model-fitting performance, prediction performance, and the spatial Moran’s I of model residuals. In addition, GNNWR models can combine the geographic information system technology for accurately expressing the spatial distribution of DW relevant information to provide the key technology that can be used as the basis for human decision-making and management planning.
Analysis of the phytochemicals of Coriandrum sativum and Cichorium intybus aqueous extracts and their biological effects on broiler chickens
Authors: Gazwi Hanaa S. S. , Mahmoud Magda E. , Toson Enas M. A. 
Published: April 2022

AbstractSpices and herbs can be used as feed additives and viable alternatives to antibiotics in chicken production. This study analyzed the phytochemicals, minerals, and antioxidant activity of aqueous extracts from Coriandrum sativum seeds and Cichorium intybus roots. The effects of different concentrations of C. sativum and C. intybus extracts on blood parameters, growth and carcass traits, biochemical parameters, and antioxidant activity of broiler chicks were also examined. The results showed that C. sativum aqueous extract has relatively higher contents of total flavonoids and total phenolic acids than C. intybus aqueous extract. Both extracts contain elevated mineral elements, especially iron, potassium, and sodium. Therefore, dietary supplementation of C. sativum seed and C. intybus root extracts could enhance broiler chicken growth performance, carcass characteristics, liver function, lipid profile, and antioxidant status. These extracts could be utilized as natural feed additives and growth promoters for broiler chickens.
Photoelectrocaloric effect in ferroelectric oxide
Authors: Pal Subhajit , Mohan Manu , Priya K. Shanmuga , Murugavel P. 
Published: April 2022

AbstractThe enhanced electrocaloric (EC) effect in solid-state-based lead-free ferroelectric Ba0.875(Bi0.5Li0.5)0.125TiO3 system is investigated under light as an external stimulus. The sample exhibits an analogous value of maximum change in entropy at Curie temperature, extracted from the two different measurements process. Notably, the sample depicts maximum value of adiabatic change in temperature (ΔT) as 1.27 K and isothermal entropy change (ΔS) as 2.05 J/K kg along with the EC coefficient value of 0.426 K mm/kV, under dark conditions. In addition, the sample exhibits > 0.5 K adiabatic temperature change over a broad temperature range (~ 35 K). Remarkably, the EC parameters display ~ 27% enhancement upon 405 nm light illumination. The demonstrated photoelectrocaloric effect is found to be in accordance with theoretical formalism. The present work elucidates the light as an additional degree of freedom to widen the potential of solid-state-based technologies for advanced environment-friendly cooling devices.