bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physico-chemical and microbiological assessment of drinking water of the selected restaurants in Mymensingh district of Bangladesh
Authors: Islam MA , Ema IJ , Usha KF , Kabir SML 
Published: March 2022

Water is essential for living organisms for their survival. Access of adequate and safe water is a basic need of human beings. In adequacy and unsafe water supply may cause various health problems. This study was designed with a view to assessing physicochemical properties of drinking water collected from different restaurants at Mymensingh sadar. In this case, electrical conductivity (EC), total dissolved solids (TDS), pH, dissolved oxygen (DO), biological oxygen demand (BOD), arsenic (As), iron (Fe) and lead (Pb) were measured. Furthermore, Microbiological assessments of drinking water samples were carried out. For achieving the microbiological assessment, methods of heterotrophic plate count (HPC) and total coliform count (TCC) were applied. The mean value of EC, TDS, pH, DO, BOD, As, Fe, Pb were 682.38 µS cm-1, 201ppm, 7.11, 4.98 mg/L, 1.72 mg/L, 0.005 ppm, 0.181 ppm and 0.000 ppm, respectively. According to the standard of drinking water the EC, TDS, pH, DO, BOD, As, Fe, Pb toxicity were not detected in all samples. All of above mentioned parameters were present in water within permissible limits. In most cases the concentrations of Pb and in some cases the concentrations of Fe were considered as toxicants due to the higher concentrations noted. The highest heterotrophic plate count was found in water of Ganginapar sample (1.2×107 CFU/ml) and the highest total coliform count was noted in C. K. Ghosh road sample (13 coliforms/100 ml). Therefore, the examined water quality parameters indicate that water quality of the restaurants at Mymensingh sadar is suitable for drinking. Although some of the samples identified as the presence of fecal coliforms that indicates contamination of feces with water. One sample among the studied drinking water samples was contaminated with fecal coliform which is very harmful for health and this water is not suitable for drinking. It may be concluded that hygienic and quality water need to supply for human drinking purposes.
Progressive Agriculture 32 (2): 84-95, 2021
TINGKAT KEPUASAN KONSUMEN TERHADAP OBJEK WISATA PANTAI NIRWANA KOTA BAUBAU
Authors: Winda - , Sadarun Baru , Mansyur Akhmad 
Published: March 2022

ABSTRAKPenelitian ini bertujuan untuk mengetahui jumlah dan jenis layanan setiap objek wisata dan untuk mengetahui tingkat kepuasan konsumen terhadap setiap layanan objek wisata di Pantai Nirwana Kota Baubau. Penelitian ini dilakukan pada Bulan Agustus 2020. Data diperoleh melalui penyebaran kuesioner, observasi dan dokumentasi menggunakan teknik accidental sampling dengan jumlah responden sebanyak 60 orang. Variabel penelitian yang diamati adalah jumlah dan jenis layanan setiap objek wisata dan tingkat kepuasan konsumen terhadap setiap layanan objek wisata di Pantai Nirwana. Data dianalisis dengan menggunakan analisis deskriptif kualitatif. Hasil penelitian ini menunjukkan ada 3 jenis layanan objek wisata yaitu layanan objek wisata wahana permainan, layanan objek wisata keindahan pantai dan layanan fasilitas penunjang. Tingkat kepuasan konsumen berdasarkan 5 dimensi kualitas pelayanan yaitu tingkat kepuasan untuk layanan objek wisata wahana permainan yang mendapatkan penilaian tertinggi yaitu kehandalan dengan range 3,7 yang menunjukkan kriteria puas. Tingkat kepuasan untuk layanan objek wisata keindahan pantai yang mendapat penilaian tertinggi yaitu bukti fisik dengan range 4,18 yang menunjukkan kriteria puas. Tingkat kepuasan untuk layanan fasilitas penunjang yang mendapatkan penilaian tertinggi yaitu bukti fisik terhadap warung/kantin dengan range 4,55 yang menunjukkan kriteria sangat puas. Kata Kunci : Objek Wisata, Kepuasan, Kualitas Layanan
KAJIAN SOSIAL EKONOMI NELAYAN RAJUNGAN PENGGUNA ALAT TANGKAP BUBU DI KECAMATAN SOROPIA KABUPATEN KONAWE
Authors: Lestari Indri , Yusuf Sarini , Kamri Syamsul 
Published: March 2022

ABSTRAK Daerah pesisir Kabupaten Konawe merupakan wilayah di Sulawesi Tenggara yang penduduknya sebagian besar bermata pencaharian sebagai nelayan termasuk nelayan rajungan. Salah satu daerah penghasil rajungan dan memiliki potensi untuk dikembangkan terdapat di Kecamatan Soropia khususnya di Desa Mekar dan Desa Leppe. Penelitian ini bertujuan untuk mengetahui kondisi sosial ekonomi nelayan rajungan pengguna alat tangkap bubu di Kecamatan Soropia Kabupaten Konawe. Penelitian dilaksanakan pada bulan Februari sampai Maret 2020. Sampel dalam penelitian ini adalah seluruh nelayan rajungan yang menggunakan bubu di kedua desa tersebut sebanyak 7 responden. Data diperoleh dengan menggunakan teknik observasi dan wawancara. Jenis data yang digunakan yaitu data primer yang meliputi luas rumah tinggal, jenis lantai dasar rumah tinggal, jenis dinding rumah tinggal, kamar mandi, sumber penerangan, sumber air minum, bahan bakar, konsumsi, pakaian, kesehatan, pendapatan, tingkat pendidikan, tabungan keluarga, jumlah tabungan keluarga, umur, pengalaman kerja, jumlah alat tangkap, jumlah hasil tangkapan sedangkan data sekunder seperti luas desa dan jumlah penduduk. Analisis data yang digunakan dalam penelitian adalah analisis deskriptif kualitatif menggunakan 14 kriteria masyarakat miskin menurut BPS. Hasil penelitian ini menunjukkan bahwa nelayan tangkap rajungan di Kecamatan Soropia tergolong dalam kategori miskin dan dapat dikatakan buruk. Dari 14 kriteria tersebut hanya terdapat 9 kriteria yang terpenuhi. Sedangkan 5 kriteria masyarakat miskin yang tidak terpenuhi seperti luas rumah tinggal berukruan 5x7 m dan ukuran 6 x 8 m, sumber penerangan rumah tangga bukan listrik, hanya membeli satu stel pakaian baru dalam setahun, kesehatan seperti gatal-gatal, demam dan batuk, pendapatan tertinggi sebesar Rp2.100.000-2.520.000, pendapatan sedang Rp1.260.000-1.470.000, dan terendah sebesar Rp650.000. Oleh karena itu kebijakan pengembangan penangkapan rajungan harus memperhatikan bukan hanya keberlanjutan sumberdaya tetapi juga kondisi sosial ekonomi nelayan. Kata kunci : Sosial, Ekonomi, Nelayan Rajungan
Adult Height in Girls With Idiopathic Premature Adrenarche: A Cohort Study and Design of a Predictive Model
Authors: Mejorado-Molano Francisco Javier , Sanz-Calvo María Luisa , Posada-Ayala Ana , Caballo-Roig Nieves , Gavela-Pérez Teresa , Mahillo-Fernández Ignacio , Soriano-Guillén Leandro 
Published: March 2022

IntroductionIdiopathic premature adrenarche (IPA) is considered a normal variant of puberty, presenting more commonly in female patients. There are concerns as to whether IPA alters the final height of these girls. Our main objectives were to (a) compare the adult height of girls with IPA against their target height and (b) design a mathematical model to predict adult height at diagnosis in female patients with IPA.Materials and MethodsA cohort study of girls with IPA was conducted from the time of IPA diagnosis until adult height. The following data were collected: target height, perinatal history, anthropometric and biochemical variables and bone age at diagnosis, age at Tanner stage 2 and menarcheal age, and adult height. First, we performed a univariate statistical analysis after which we carried out a multiple linear regression analysis using adult height as the dependent variable.ResultsWe obtained data from 79 female patients diagnosed with IPA with a mean adult height of 164.6 cm (95% CI: 163.36–165.85 cm). The mean follow-up time was 6.60 years. Average age at Tanner stage 2 was 9.71 years. Mean menarcheal age was 11.64 years. There were no significant differences between target height and adult height. Of the several predictive models designed for these patients, one of them, which included bone age, obtained an R2 value of 71%.ConclusionsAlthough slightly advanced puberty was observed among the girls with IPA, their adult height was preserved. The use of predictive models of adult height on diagnosis of IPA could facilitate closer follow-up of girls at risk of reduced adult height.
Resident Perceptions and Parcel-Level Performance Outcomes of Mangroves, Beaches, and Hardened Shorelines After Hurricane Irma in the Lower Florida Keys
Authors: O’Donnell Kiera L. , Tomiczek Tori , Scyphers Steven B. 
Published: March 2022

Hurricanes have large and lasting effects along coastlines, representing one of the deadliest and costliest natural hazards. Among the rapidly growing literature on the impacts of hurricanes, an increasing topic of interest is the potential role of mangroves, and other coastal habitats, as nature-based strategies (NBS) for coastal defense. In addition to coastal protection, NBS have been shown to provide many ecological, economic, and social co-benefits. However, few studies have assessed coastal resident perceptions or residential-scale performance of NBS, particularly in the wake of major hurricanes. Through a survey of 288 residents of the Lower Florida Keys 1 year after Hurricane Irma, this paper describes hurricane impacts on mangroves, beaches, and hardened shorelines. Specifically, we measured perceptions of shoreline damage and shoreline effectiveness for coastal protection at the community- and parcel-levels. At the parcel scale, we also measured performance outcomes through the cost to repair or replace residential shorelines. At both community- and parcel-levels, beaches were perceived as the most damaged shoreline type, followed by mangroves, and then hardened shorelines as the least damaged. Specifically at the parcel-level, repair actions were not taken by many residents with a hardened shoreline (43.2%) due to their shoreline receiving no damage. However, when repair actions were taken, the average cost to repair or replace parcel-level mangroves ($64.33 (USD)±SE 58.08 per meter) was less than hardened shorelines ($105.14 (USD)±SE 38.57 per meter). Additionally, 44% of residents reported that no repair or recovery actions were needed after the storm for damaged mangroves, whereas when hardened structures were damaged, many required at least minor repairs (29.5%). Mangroves were also perceived as the most effective shoreline for storm protection (54%verytoextremely effective) at the community-level. Our findings indicate local community-level awareness of the storm protective properties mangroves provide but also display a disconnect between perceptions and performance outcomes at parcel scales. Although mangroves cost less to repair and are perceived as the most effective at storm protection, the majority of Florida Keys residents own hardened shorelines. Considering the diverse co-benefits mangroves provide and the local support mangroves have, their conservation and restoration could be well-supported for coastal adaptation.
Short Tandem Repeat Variation in the CNR1 Gene Associated With Analgesic Requirements of Opioids in Postoperative Pain Management
Authors: Kasai Shinya , Nishizawa Daisuke , Hasegawa Junko , Fukuda Ken-ichi , Ichinohe Tatsuya , Nagashima Makoto , Hayashida Masakazu , Ikeda Kazutaka 
Published: March 2022

Short tandem repeats (STRs) and variable number of tandem repeats (VNTRs) that have been identified at approximately 0.7 and 0.5 million loci in the human genome, respectively, are highly multi-allelic variations rather than single-nucleotide polymorphisms. The number of repeats of more than a few thousand STRs was associated with the expression of nearby genes, indicating that STRs are influential genetic variations in human traits. Analgesics act on the central nervous system via their intrinsic receptors to produce analgesic effects. In the present study, we focused on STRs and VNTRs in the CNR1, GRIN2A, PENK, and PDYN genes and analyzed two peripheral pain sensation-related traits and seven analgesia-related traits in postoperative pain management. A total of 192 volunteers who underwent the peripheral pain sensation tests and 139 and 252 patients who underwent open abdominal and orthognathic cosmetic surgeries, respectively, were included in the study. None of the four STRs or VNTRs were associated with peripheral pain sensation. Short tandem repeats in the CNR1, GRIN2A, and PENK genes were associated with the frequency of fentanyl use, fentanyl dose, and visual analog scale pain scores 3 h after orthognathic cosmetic surgery (Spearman’s rank correlation coefficient ρ = 0.199, p = 0.002, ρ = 0.174, p = 0.006, and ρ = 0.135, p = 0.033, respectively), analgesic dose, including epidural analgesics after open abdominal surgery (ρ = −0.200, p = 0.018), and visual analog scale pain scores 24 h after orthognathic cosmetic surgery (ρ = 0.143, p = 0.023), respectively. The associations between STRs in the CNR1 gene and the frequency of fentanyl use and fentanyl dose after orthognathic cosmetic surgery were confirmed by Holm’s multiple-testing correction. These findings indicate that STRs in the CNR1 gene influence analgesia in the orofacial region.
Sex-Differences in Oral Anticoagulant-Related Intracerebral Hemorrhage
Authors: Grundtvig Josefine , Ovesen Christian , Steiner Thorsten , Carcel Cheryl , Gaist David , Christensen Louisa , Marstrand Jacob , Meden Per , Rosenbaum Sverre , Iversen Helle K. , Kruuse Christina , Christensen Thomas , Ægidius Karen , Havsteen Inger , Christensen Hanne 
Published: March 2022

Introduction and AimData remain limited on sex-differences in patients with oral anticoagulant (OAC)-related intracerebral hemorrhage (ICH). We aim to explore similarities and differences in risk factors, acute presentation, treatments, and outcome in men and women admitted with OAC-related ICH.MethodThis study was a retrospective observational study based on 401 consecutive patients with OAC-related ICH admitted within 24 h of symptom onset. The study was registered on osf.io. We performed logarithmic regression and cox-regression adjusting for age, hematoma volume, Charlson Comorbidity Index (CCI), and pre-stroke modified Ranking Scale (mRS). Gender and age were excluded from CHA2DS2-VASc and CCI was not adjusted for age.ResultsA total of 226 men and 175 women were identified. More men were pre-treated with vitamin K-antagonists (73.5% men vs. 60.6% women) and more women with non-vitamin K-antagonist oral anticoagulants (26.5% men vs. 39.4% women), p = 0.009. Women were older (mean age 81.9 vs. 76.9 years, p &lt; 0.001). CHA2DS2-VASc and CCI were similar in men and women.Hematoma volumes (22.1 ml in men and 19.1 ml in women) and National Institute of Health Stroke Scale (NIHSS) scores (13 vs. 13) were not statistically different, while median Glasgow Coma Scale (GCS) was lower in women, (14 [8;15] vs. 14 [10;15] p = 0.003).Women's probability of receiving reversal agents was significantly lower (adjusted odds ratio [aOR] = 0.52, p = 0.007) but not for surgical clot removal (aOR = 0.56, p = 0.25). Women had higher odds of receiving do-not-resuscitate (DNR) orders within a week (aOR = 1.67, p = 0.04). There were no sex-differences in neurological deterioration (aOR = 1.48, p = 0.10), ability to walk at 3 months (aOR = 0.69, p = 0.21) or 1-year mortality (adjusted hazard ratio = 1.18, p = 0.27).ConclusionSignificant sex-differences were observed in age, risk factors, access to treatment, and DNRs while no significant differences were observed in comorbidity burden, stroke severity, or hematoma volume. Outcomes, such as adjusted mortality, ability to walk, and neurological deterioration, were comparable. This study supports the presence of sex-differences in risk factors and care but not in presentation and outcomes.
SNCA rs3910105 Is Associated With Development of Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease
Authors: Yang Nan-nan , Sang Shu-shan , Peng Tao , lu Hong 
Published: March 2022

Background and PurposeRapid eye movement (REM) Rapid eye movement sleep behavior disorder (RBD) is a common non-motor symptom of PD. However, the association between the SNCA rs3910105 genotype and RBD in Parkinson’s disease (PD) remains unclear.MethodsThis study used Parkinson’s Progression Markers Initiative (PPMI) data and included 270 patients with newly diagnosed PD without RBD who were divided into SNCA rs3910105 C carriers (CC+CT; n = 187) and TT carriers (n = 83). They were followed up for 5 years to identify the development of RBD. To investigate the influence of cerebrospinal fluid (CSF) alpha-synuclein (α-syn) and β-amyloid 1–42 (Aβ42) in the association between rs3910105 and RBD, the patients were additionally classified into “high-level” and “low-level” groups using cutoff values for CSF α-syn and Aβ42 levels.ResultsAt baseline, the rs3910105 C allele group had lower CSF α-syn and Aβ42 levels than the TT group. During the 5.0-year follow-up, the rs3910105 C allele group had a higher incidence of RBD than the TT group. In the subgroup analyses, the effect of the rs3910105 C allele was not found in the “low-level” group. However, in the “high-level” group, the rs3910105 C allele independently increased the risk of RBD.ConclusionThe SNCA rs3910105 C allele might be a novel genetic risk factor for RBD development in PD, α-syn pathways might have a role in this association and more basic research would be needed to elucidate the mechanism in the future.
The Difficult Decision Not to Prescribe Artificial Nutrition by Health Professionals and Family: Bioethical Aspects
Authors: Pereira Andrea Z. , da Cunha Selma Freire de Carvalho , Grunspun Henrique , Bueno Marco Aurelio Scarpinella 
Published: March 2022

IntroductionBioethics and nutrition are essential issues in end of life, advanced dementia, life-sustaining therapies, permanent vegetative status, and unacceptably minimal quality of life. Even though artificially administered nutrition (AAN), for this type of health condition, does not improve quality of life and extension of life, and there is evidence of complications (pulmonary and gastrointestinal), it has been used frequently. It had been easier considering cardiopulmonary resuscitation as an ineffective treatment than AAN for a healthy team and/or family. For this reason, many times, this issue has been forgotten.ObjectivesThis study aimed to discuss bioethical principles and AAN in the involved patients.DiscussionThe AAN has been an essential source of ethical concern and controversy. There is a conceptual doubt about AAN be or not be a medical treatment. It would be a form of nourishment, which constitutes primary care. These principles should be used to guide the decision-making of healthcare professionals in collaboration with patients and their surrogates.ConclusionsThis difficult decision about whether or not to prescribe AAN in patients with a poor prognosis and without benefits should be based on discussions with the bioethics committee, encouraging the use of advanced directives, education, and support for the patient, family, and health team, in addition to the establishment of effective protocols on the subject. All of this would benefit the most important person in this process, the patient.
Association Between Consumption of Fermented Food and Food-Derived Prebiotics With Cognitive Performance, Depressive, and Anxiety Symptoms in Psychiatrically Healthy Medical Students Under Psychological Stress: A Prospective Cohort Study
Authors: Karbownik Michał Seweryn , Mokros Łukasz , Dobielska Maria , Kowalczyk Mateusz , Kowalczyk Edward 
Published: March 2022

BackgroundGut microbiota-based therapeutic strategies, such as probiotic and prebiotic preparations, may benefit mental health. However, commonly consumed fermented and prebiotic-containing foods have not been well-tested. The aim of the present study was to determine whether consumption of fermented food and food-derived prebiotics is associated with cognitive performance, depressive, and anxiety symptoms in psychiatrically healthy medical students under psychological stress.MethodsThe study protocol with data analysis plan was prospectively registered. Food consumption was evaluated with a 7-day dietary record. Cognitive performance was modeled with academic examination performance in relation to subject knowledge. Pre-exam depressive and anxiety symptoms were assessed with the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7, respectively.ResultsIn total, 372 medical students (22.7 ± 1.1 years of age, 66% female) completed the study. No relationship was observed between cognitive performance under stress and either fermented food (adjusted β 0.02, 95% CI −0.07–0.11, p = 0.63) or food-derived prebiotics consumption (adjusted β −0.00, 95% CI −0.09–0.09, p = 0.99). High intake of fermented food was associated with more severe depressive (adjusted β 0.11, 95% CI 0.01–0.20, p = 0.032) and anxiety symptoms under stress (adjusted β 0.13, 95% CI 0.04–0.22, p = 0.0065); however, no such link was observed for food-derived prebiotics (adjusted β 0.03, 95% CI −0.07–0.13, p = 0.50 and −0.01, 95% CI −0.11–0.08, p = 0.83, for depression and anxiety, respectively).ConclusionsUnder psychological stress in medical students, consumption of fermented food and food-derived prebiotics appears to be not associated with cognitive performance. High intake of fermented food, but not food-derived prebiotics, may be associated with severity of depressive and anxiety symptoms. The safety of fermented food in this regard therefore requires further clarification.