bluuebunny/crossref_metadata_2025_split huggingface dataset:
“EdTech Integration Framework in Schools”: Systematic Review of the Literature
Authors: Sosa-Díaz María José , Sierra-Daza María Caridad , Arriazu-Muñoz Rubén , Llamas-Salguero Fátima , Durán-Rodríguez Noelia 
Published: May 2022

The process of integration of Information and Communication Technologies (ICT) in the Educational System is a dynamic process influenced by multiple interdependent factors. The most relevant studies published to date have highlighted the following as systemic levels of ICT integration: teachers, schools, and educational policy. The general objective of this work is to carry out a Systematic Literature Review (SLR) on the strategic planning of technology in primary and secondary schools from 2010 to 2021. This study is supported by a qualitative methodology based on a SLR, guided by the PRISMA protocol. For this purpose, a keyword-based document search was carried out in three databases: Eric, Scopus, and WOS. For the collection of information, the criteria applied for the inclusion of papers was by date (last 12 years) and type of document (journal articles). A total of 6,187 scientific journal articles were initially included in the CADIMA platform, where finally, after screening, 42 articles were selected that met the established criteria: studies with teachers and students in the educational stages of Primary and Secondary Education, excluding Higher Education. Empirical studies with quantitative and/or qualitative methods are also included, discarding theoretical studies. Research on digital technologies from a general perspective is also considered relevant, excluding studies on specific technologies. This SLR concludes by providing an explanatory theoretical model, defining the integration of ICT in educational centres as a complex, systemic and ecological process, where legislative and organisational structures, such as leadership, strategic planning, and collaboration among professionals, are essential elements. Therefore, the incorporation of technology in the classroom requires a redefinition of the organisational culture of schools.Systematic Review Registration: [zenodo.org], identifier [6343639].
Deficiency of RARα Suppresses Decidualization via Downregulating CEBPB Transcription in Women With Recurrent Implantation Failure
Authors: Huang Caiyi , Zhang Qian , Ni Tianxiang , Zhou Tingting , Lv Chunzi , Li Yan , Yan Junhao , Chen Zi-Jiang 
Published: May 2022

BackgroundRecurrent implantation failure (RIF) is a disease associated with endometrial receptivity dysfunction. Retinoic acid receptor alpha (RARα) is an important protein in many biological processes, such as differentiation and development. However, the exact underlying mechanism whereby RARα affects RIF remains unknown. This study investigated RARα expression and its contribution in the mid-luteal phase endometria of patients with RIF.MethodsThe expression levels of RARα and CCAAT/enhancer-binding protein (C/EBP) β in the endometria of the RIF and normal group were investigated using western blotting and immunohistochemistry. In in vitro experiments, immortal telomerase-transformed human endometrial stromal cells (T-HESCs) were incubated with medroxyprogesterone-17-acetate (MPA) and cyclic adenosine monophosphate (cAMP) for 4 days to induce decidualization. The expression levels of the decidualization markers prolactin (PRL) and insulin-like growth factor-binding protein-1 (IGFBP-1) were determined using quantitative polymerase chain reaction. RARα was knocked down using a small interfering RNA, and C/EBPβ was overexpressed from an adenoviral vector. The transcriptional regulation of CEBPB by RARα was determined by chromatin immunoprecipitation (ChIP) assay and luciferase assays.ResultsWe found that the expression levels of RARα decreased in the mid-luteal endometria of RIF patients. After 4 days of decidualization induction in vitro, RARα knockdown impaired the decidualization of T-HESCs and downregulated the expression of C/EBPβ. The restoration of C/EBPβ expression rescued the RARα knockdown-induced suppression of T-HESC decidualization. In ChIP analysis of lysates from decidualized T-HESCs, the CEBPB promoter region was enriched in chromatin fragments pulled down using an anti-RARα antibody. However, the relationship between CEBPB transcription and RARα expression levels was only observed when the decidualization of T-HESCs was induced by the addition of cAMP and MPA. To identify the binding site of RARα/retinoid X receptor α, we performed luciferase assays. Mutation of the predicted binding site in CEBPB (-2,009/-1,781) decreased the transcriptional activity of the reporter. To confirm this mechanism, the expression levels of C/EBPβ in the mid-luteal endometria of RIF patients were determined and found to decrease with decreased RARα expression levels.ConclusionA deficiency of RARα expression in the mid-luteal endometrium inhibits decidualization due to the downregulation of CEBPB transcription. This is a potential mechanism contributing to RIF.
Hyperuricemia is Associated With 2- and 5-Year Adverse Outcomes in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention
Authors: Tang Xiao-Fang , He Chen , Zhu Pei , Zhang Che , Song Ying , Xu Jing-Jing , Yao Yi , Xu Na , Jiang Ping , Jiang Lin , Gao Zhan , Zhao Xue-yan , Gao Li-jian , Song Lei , Yang Yue-Jin , Gao Run-Lin , Xu Bo , Yuan Jin-Qing 
Published: May 2022

BackgroundHyperuricemia has recently been identified as a risk factor of cardiovascular diseases; however, prognostic value of hyperuricemia in patients with ST-segment elevation myocardial infarction (STEMI) remained unclear. Simultaneously, the mechanism of this possible relationship has not been clarified. At present, some views believe that hyperuricemia may be related to the inflammatory response. Our study aimed to investigate the association between hyperuricemia and long-term poor prognosis and inflammation in STEMI patients undergoing percutaneous coronary intervention (PCI).MethodsA total of 1,448 consecutive patients with STEMI were studied throughout 2013 at a single center. The primary endpoint was all-cause death at 2- and 5-year follow-up. Inflammatory biomarkers were collected on admission of those patients: high sensitive C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and white blood cell (WBC) count.ResultsHyperuricemia was associated with higher 2- and 5-year all-cause death in STEME patients compared to normouricemia (5.5% vs. 1.4%, P &lt;0.001; 8.0% vs 3.9%, P = 0.004; respectively). After multivariable adjustment, hyperuricemia was still an independent predictor of 2-year all-cause death (hazard ratio (HR) =4.332, 95% confidence interval (CI): 1.990–9.430, P &lt;0.001) and 5-year all-cause death (HR =2.063, 95% CI: 1.186–3.590, P =0.010). However, there was no difference in hs-CRP, ESR, and WBC count on admission in STEMI patients with hyperuricemia compared to normouricemia (P &gt;0.05).ConclusionsHyperuricemia was associated with higher risks of 2- and 5-year all-cause deaths in patients with STEMI undergoing PCI. However, this study did not find a correlation between hyperuricemia and inflammatory responses in newly admitted STEMI patients.
Microbial Infection and Antibiotic Susceptibility of Diabetic Foot Ulcer in China: Literature Review
Authors: Du Fang , Ma Jing , Gong Hongping , Bista Raju , Zha Panpan , Ren Yan , Gao Yun , Chen Dawei , Ran Xingwu , Wang Chun 
Published: May 2022

ObjectiveTo investigate the microbial spectrum isolated from foot ulcers among diabetic patients in China, which was conducted to help clinicians choose optimal antibiotics empirically.MethodThe PubMed, MEDLINE, Web of Science, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), WanFang, and VIP databases were searched for studies published between 2015 to 2019, that report primary data on diabetic foot infection (DFI) and antibiotic susceptibility in China.ResultA total of 63 articles about DFI and antibiotic susceptibility tests among diabetic patients in China were included. There were 11,483 patients with an average age of 60.2 ± 10.1 years and a mean course of 10.6 ± 5.0 years between 2010 and 2019, covering most geographical regions of China. The prevalence of Gram-positive (GP) bacteria (43.4%) was lower than that of Gram-negative (GN) (52.4%). The most prevalent pathogens isolated were Staphylococcus aureus (17.7%), Escherichia coli (10.9%), Pseudomonas aeruginosa (10.5%), Klebsiella pneumoniae (6.2%), Staphylococcus epidermidis (5.3%), Enterococcus faecalis (4.9%), and fungus (3.7%). The prevalence of polymicrobial infection was 22.8%. GP bacteria were sensitive to linezolid, vancomycin, and teicoplanin. More than 50% of GN bacteria were resistant to third-generation cephalosporins, while the resistance rates of piperacillin/tazobactam, amikacin, meropenem, and imipenem were relatively low. Among the 6017 strains of the isolated organisms, 20% had multi-drug resistance (MDR). Staphylococcus aureus (30.4%) was the most predominant MDR bacteria, followed by extended-spectrum β-lactamase (ESBL) (19.1%).ConclusionThe microbial infection of foot ulcers among diabetic patients in China is diverse. The microbial spectrum is different in different geographic regions and Staphylococcus aureus is the predominant bacteria. Polymicrobial and MDR bacterial infections on the foot ulcers are common. This study could be valuable in guiding the empirical use of antibiotics for diabetic foot infections.
Artificial Intelligence-Aided Meta-Analysis of Toxicological Assessment of Agrochemicals in Bees
Authors: Bernardes Rodrigo Cupertino , Botina Lorena Lisbetd , Araújo Renan dos Santos , Guedes Raul Narciso Carvalho , Martins Gustavo Ferreira , Lima Maria Augusta Pereira 
Published: May 2022

The lack of consensus regarding pollinator decline in various parts of the planet has generated intense debates in different spheres. Consequently, much research has attempted to identify the leading causes of this decline, and a multifactorial synergism (i.e., different stressors acting together and mutually potentiating the harmful effects) seems to be the emerging consensus explaining this phenomenon. The emphasis on some stressor groups such as agrochemicals, and pollinators such as the honey beeApis mellifera, can hide the real risk of anthropogenic stressors on pollinating insects. In the present study, we conducted a systematic review of the literature to identify general and temporal trends in publications, considering the different groups of pollinators and their exposure to agrochemicals over the last 76 years. Through an artificial intelligence (AI)-aided meta-analysis, we quantitatively assessed trends in publications on bee groups and agrochemicals. Using AI tools through machine learning enabled efficient evaluation of a large volume of published articles. Toxicological assessment of the impact of agrochemicals on insect pollinators is dominated by the order Hymenoptera, which includes honey bees. Although honey bees are well-explored, there is a lack of published articles exploring the toxicological assessment of agrochemicals for bumble bees, solitary bees, and stingless bees. The data gathered provide insights into the current scenario of the risk of pollinator decline imposed by agrochemicals and serve to guide further research in this area.Systematic Review Registrationhttps://asreview.nl/.
Child-Onset Cerebellar Ataxia Caused by Two Compound Heterozygous Variants in ADPRS Gene: A Case Report
Authors: Ma Jiehui , Qian Qiaoqiao , Yan Shuang , Dou Haoyu , Li Cheng , Sun Dan 
Published: May 2022

Background: Gene variants of ADP-ribosylserine hydrosylase, also known as ADP-ribosylhydrolase-like 2 (ADPRS or ADPRLH2; OMIM: 610624), can cause stress-induced childhood-onset neurodegeneration with variable ataxia and seizures (CONDSIAS, OMIM: 618170), an ultra-rare neurodegenerative autosomal recessive disorder. ADPRS encodes ADP-ribosylhydrolase 3, which removes poly(ADP-ribose) polymers, whose posttranslational addition occurs under stressful conditions.Case Presentation: After a respiratory tract infection, a 30-month-old male patient presented with unsteady gait that rendered walking impossible without external help. Neurological examination revealed acute cerebellar ataxia, electroencephalogram results were abnormal, and brain magnetic resonance imaging revealed slightly widened cerebellar sulci. Laboratory tests showed decreased levels of thyroid-stimulating hormone, and increased levels of plasma lactic acid and serum cardiac enzymes. The cerebrospinal fluid glucose test was positive. Four months after onset, the patient died of sudden convulsions. Using whole exome sequencing, we identified two novel compound heterozygous ADPRS variants: NM_017825.3:c.580C&gt;T (p.Gln194Ter) and NM_017825.3:c.803-1G&gt;A. RNA sequencing indicated that the former mutation might cause nonsense-mediated mRNA decay. The c.803-1G&gt;A variant was found to be a splice-site mutation that leads to the transcriptional retention of intron 5. According to the guidelines of the American College of Medical Genetics and Genomics, the two variants were classified as pathogenic.Conclusion: We present the first report of the existence of two compound heterozygous variants of ADPRS, which leads to CONDSIAS.
Preferences for Multipurpose Technology and Non-oral Methods of Antiretroviral Therapy Among Women Living With HIV in Western Kenya: A Survey Study
Authors: Bernard Caitlin , Jakait Beatrice , Fadel William F. , Mocello A. Rain , Onono Maricianah A. , Bukusi Elizabeth A. , Wools-Kaloustian Kara K. , Cohen Craig R. , Patel Rena C. 
Published: May 2022

IntroductionUnderstanding interests in and preferences for multipurpose technology (MPT) for the co-administration of contraception and antiretroviral therapy (ART) and alternative, non-oral ART methods among women living with HIV (WLHIV) is vital to successful implementation of future treatment options, such as long-acting injectable ART.MethodsBetween May 2016 and March 2017 we conducted a cross-sectional telephone survey of 1,132 WLHIV of reproductive potential with prior experience using intermediate- or long-acting contraceptive methods in western Kenya. We present descriptive statistics and multinomial logistic regression to evaluate predictors of interest in specific MPT and non-oral ART methods.ResultsTwo-thirds (67%) reported interest in MPT, with the most common reason for interest being ease of using a single medication for both purposes of HIV treatment and pregnancy prevention (26%). Main reasons for lack of interest in MPT were need to stop/not use contraception while continuing ART (21%) and risk of side effects (16%). Important characteristics of MPT were effectiveness for pregnancy prevention (26%) and HIV treatment (24%) and less than daily dosing (19%). Important characteristics of non-oral ART methods were less than daily dosing (47%), saving time accessing ART (16%), and effectiveness of HIV treatment (15%). The leading preferred methods for both MPT and non-oral ART were injectables (50 and 54%) and implants (32 and 31%). Prior use of a contraceptive implant or injectable predicted interest in similar methods for both MPT and non-oral ART methods, while this relationship did not appear to vary between younger vs. older WLHIV.DiscussionMost WLHIV in western Kenya are interested in MPT for HIV treatment and contraception. Prior exposure to contraceptive implants or injectables appears to predict interest in similar methods of MPT and non-oral ART. Developers of MPT and non-oral ART methods should strongly consider WLHIV's preferences, including their changing reproductive desires.
Hyper-Reflecting Foci in Multiple Sclerosis Retina Associate With Macrophage/Microglia-Derived Cytokines in Cerebrospinal Fluid
Authors: Puthenparampil Marco , Torresin Tommaso , Franciotta Silvia , Marin Annachiara , De Napoli Federica , Mauceri Valentina Annamaria , Miante Silvia , Pilotto Elisabetta , Midena Edoardo , Gallo Paolo 
Published: May 2022

BackgroundIncreasing evidence suggests that retinal hyper-reflecting foci (HRF) might be clusters of activated and proliferating microglia. Since microglia are widespread activated in multiple sclerosis (MS) brain, its evaluation in retina may help to understand and monitor MS-related pathology.AimThis study aims at investigating the association of HRF with cerebrospinal fluid (CSF) cytokines and MRI parameters in relapsing–remitting MS (RRMS).MethodsNineteen RRMS at clinical onset and 15 non-inflammatory neurological disorders (NIND) underwent brain 3T MRI and CSF examination. Optical coherence tomography (OCT) analysis, including HRF count, was performed on RRMS patients. Sixty-nine cytokines/chemokines were analyzed in the CSF by multiplex technology.ResultsIn RRMS, HRF count in the ganglion cell layer (GCL) was associated with IL-1Ra, IL-9, IL-15, IFN-γ, and G-CSF. Moreover, in RRMS patients CSF concentrations of IL-1Ra and G-CSF associated with global cortical thickness. The HRF count in the inner nuclear layer (INL) correlated with IL-22, IL-34, IL-35, CXCL-2, CXCL-10, and CXCL-13, and multivariate analysis confirmed a strong association (r2: 0.47) with both CXCL-2 (β: -0.965, p = 0.0052) and CXCL-13 (β: 0.241, p = 0.018). This latter cytokine increased in RRMS with high HRF count compared with NIND and RRMS with low HRF count. Finally, the CXCL-13/CXCL-2 ratio strongly associated with HRF count (r: 0.8, p &lt; 0.005) and cortical lesion volume (r: 0.5, p &lt; 0.05).ConclusionsThe association of HRF with intrathecally produced monocyte/microglia-derived cytokines confirms their microglial origin and indicates they are worth further evaluating as markers of activated microglia.
Nitracentric/Hydrographic Classification and Prediction of Nitrate Profiles for Oceanographic Stations Under the Influence of Mesoscale Eddies in the Gulf of Mexico
Authors: Velásquez-Aristizábal Jorge A. , Camacho-Ibar Víctor F. , Durazo Reginaldo , Valencia-Gasti José A. , Lee-Sánchez Erika , Trasviña-Castro Armando 
Published: May 2022

In the ocean, nitrogen availability is an important control of primary production and influences the amount of energy flowing through food webs. Mesoscale eddies play important roles in modulating the spatial distributions of physical and biogeochemical properties in the Gulf of Mexico (GM), including the availability of nitrate + nitrite (NN). In this study, we explore an oceanographic station classification based on the integrated NN stock that we have named the “nitracentric classification” and a classification based on hydrographic variables that we call the Best Fit Variables (BFVs), such as the depth of the 20°C isotherm and the depth of the 26 kg m-3 isopycnal, to identify stations under the influence of mesoscale eddies. We analyzed hydrographic profiles of CTD data and the NN concentrations in discrete samples collected in June 2016 during the oceanographic campaign XIXIMI-5, which was conducted in the deep-water region of the GM. The best station separation was produced when the NN concentration was integrated between the surface and 200 m depth, which was supported by the station classification based on the BFVs. Our classification system produces a better separation between station groups when compared to other classifications that rely on the use of altimetric variables and hydrographic criteria that have been previously employed to study biogeochemical and physical processes in the GM. We obtained parameterizations that accurately predicted the NN profiles between 100–500 m of stations sampled under stratified conditions in two other XIXIMI cruises in the gulf, although the parameterization has to be adapted to obtain accurate predictions under winter mixing conditions. Our results can be used to predict nitrate stocks and profiles based on a single BFV value obtained from the existing hydrographic databases of the GM as well as from CTD data at the time of sampling. The analysis of the CLIVAR Section A22 in the Caribbean Sea indicates that the nitracentric and hydrographic classification methodology developed in this study can also be applied to other oligotrophic basins where mesoscale eddies play important roles in controlling the distributions of hydrographic and biogeochemical properties.
Ternary Logics Based on 2D Ferroelectric-Incorporated 2D Semiconductor Field Effect Transistors
Authors: Zhao Guangchao , Wang Xingli , Yip Weng Hou , Vinh Huy Nguyen To , Coquet Philippe , Huang Mingqiang , Tay Beng Kang 
Published: May 2022

Ternary logic has been proven to carry an information ratio 1.58 times that of binary logic and is capable to reduce circuit interconnections and complexity of operations. However, the excessive transistor count of ternary logic gates has impeded their industry applications for decades. With the modulation of the ferroelectric negative capacitance (NC) properties on the channel potential, MOSFETs show many novel features including steep subthreshold swing and non-saturation output characteristics, based on which an ultra-compact ternary inverter can be achieved. Compared with traditional bulk materials, layered 2D materials and 2D ferroelectrics provide a clean interface and better electrostatic control and reliability. Even though ultra-low SS (∼10 mV/dec) has been experimentally demonstrated in ferroelectric-negative capacitance-incorporated 2D semiconductor (NC2D) FETs, the available models are still rare for large-scale circuit simulations. In this study, the superb electrical properties of pure 2D material stack-based NC2D FETs (layered CuInP2S6 adopted as the 2D ferroelectric layer) are investigated through device modeling based on the Landau–Khalatnikov (LK) equations in HSPICE. We managed to realize an ultra-compact ternary inverter with one NC2D-PMOS (WSe2) and one NC2D-NMOS (MoS2) in HSPICE simulations, whose transistor count is significantly reduced compared with other counterparts. We also proposed a novel input waveform scheme to solve the hysteresis problem caused by ferroelectric modulation to avoid logic confusion. Additionally, the power consumption and propagation delay of the NC2D-based ternary inverter are also investigated. This work may provide some insights into the design and applications of ferroelectric-incorporated 2D semiconductor devices.