bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing impact of an interdisciplinary erythropoiesis‐stimulating agent dosing protocol at an outpatient community hospital hemodialysis unit
Authors: Dubovetsky Dennis , Tyler Joshua , Bisceglia Sarah 
Published: July 2022

AbstractBackgroundIn adult patients with end‐stage kidney disease (ESKD), the Kidney Disease Improving Global Outcomes (KDIGO) guideline for anemia management suggests initiation of erythropoiesis‐stimulating agents (ESA) when hemoglobin (Hb) concentration is between 9 and 10 g/dL to avoid Hb below 9 g/dL and not to exceed Hb of 11.5 g/dL. Pharmacist‐led protocol for ESA dosing was implemented at an outpatient hemodialysis unit to provide standardized dosing of ESA therapy and to attain target Hb.ObjectiveThe objective of this study was to determine the impact of a pharmacist‐directed protocol on anemia management.MethodsThe study was a single‐center, retrospective cohort comparing the 6‐month outcomes between the protocol and randomly selected historic control groups. The primary endpoint was the percentage of time in therapeutic range (TTR) of Hb range: 9.5 to 10.9 g/dL. Secondary objectives were Hb concentrations, iron indices, number of red blood cell transfusions, hospital admissions due to cardiovascular events, use of alteplase for hemodialysis catheter thrombosis, and ESA and intravenous iron dosing.ResultsOne hundred and twenty‐nine adult patients with ESKD were included with 61 patients assigned to the intervention group and 68 patients in the control group. Primary endpoint of TTR within target Hb 9.5 to 10.9 g/dL was similar between the protocol and control groups (30.7% vs 29.3%, P = .177). Median weekly doses of ESA were significantly lower in the protocol group (10 064 units vs 15 227 units, P = .035).ConclusionThis study suggests that the protocol‐driven treatment was as effective as the control with respect to TTR for target Hb values, while leading to a significant reduction in ESA doses and drug‐associated costs.
Macroeconomic forecasting in a multi‐country context
Authors: Bai Yu , Carriero Andrea , Clark Todd E. , Marcellino Massimiliano 
Published: July 2022

AbstractIn this paper, we propose a hierarchical shrinkage approach for multi‐country VAR models. In implementation, we consider three different scale mixtures Normals priors and provide new theoretical results. Empirically, we examine how model specifications and prior choices affect the forecasting performance for GDP growth, inflation, and a short‐term interest rate for the G7 economies. We find that hierarchical shrinkage, particularly as implemented with the Horseshoe prior, is very useful in forecasting inflation. It also has the best density forecast performance for output growth and the interest rate. Multi‐country models generally improve on the forecast accuracy of single‐country models.
A new multiphase calcium phosphate graft material improves bone healing—An in vitro and in vivo analysis
Authors: Guastaldi Fernando Pozzi Semeghini , Matheus Henrique Rinaldi , Faloni Ana Paula de Souza , de Almeida‐Filho Edson , Cominotte Mariana Aline , Moretti Livia Alves Correa , Verzola Mario Henrique Arruda , Marcantonio Elcio , de Almeida Juliano Milanezi , Guastaldi Antonio Carlos , Cirelli Joni Augusto 
Published: July 2022

AbstractThis study aims to evaluate the potential of a novel biomaterial synthesized from amorphous calcium phosphate (ACP), octacalcium phosphate (OCP), and hydroxyapatite (HA) to repair critical‐sized defects (CSD) in rabbit calvaria. In vitro analyses of cell viability, cell proliferation, formation of mineral nodules, and cell differentiation using qPCR were performed for comparing experimental calcium phosphate (ECP), deproteinized bovine bone (DBB), and beta‐tricalcium phosphate (β‐TCP). Bilateral CSDs were created in 45 rabbit calvaria. Six groups were evaluated: ECP, ECP + fibrin sealant (ECP + S), coagulum, autogenous bone, DBB, and β‐TCP. Euthanasia was performed at 2, 4, and 8 weeks, followed by micro‐computed tomography and histological and immunohistochemical analyses. Results from in vitro analyses revealed similar biocompatibility for all tested materials and a tendency for higher gene expression of some bone markers in the ECP group than in β‐TCP and DBB groups at 7 days. In contrast to that in DBB and β‐TCP groups, ECP displayed growing bone volume over total volume percentage (BV/TV%) with time in vivo. Histological analysis revealed a greater number of giant cells and reduced size of grafted particles in ECP during all periods of analysis. RUNX‐2 expression was statistically lower in ECP than DBB at 2 and 4 weeks. Despite no statistical significance, ECP presented the highest absolute values for ALP‐expression at 2, 4, and 8 weeks compared with other groups. Together, our findings indicate that a combination of the ACP, OCP, and HA phases into ECP is beneficial and promising for bone regeneration.
Hsa_circ_0088196 suppresses trophoblast migration and invasion by the miR‐525‐5p/ABL1 axis and the PI3K/AKT signaling pathway
Authors: Shi Fenglian , Li Li 
Published: July 2022

AbstractOur study aimed to explore the role of circ_0088196 (circular TNC [circTNC]) in trophoblast invasion and migration in preeclampsia (PE) both in vitro and in vivo. CircTNC, miR‐525‐5p, and ABL1 expression in trophoblast HTR8/SVneo cells were evaluated by quantitative real‐time polymerase chain reaction (qRT‐PCR). Cell viability, migration, and invasion were detected by Cell Counting Kit‐8 (CCK‐8), wound healing, and Transwell assays. The binding between circTNC (or ABL1) and miR‐525‐5p was validated by RNA pulldown and luciferase reporter assays. The mouse model of PE was injected with sh‐circTNC and the effects of circTNC knockdown on the mean artery pressure, urine protein concentration, and fetal survival number of pregnant mice were examined. The expression of MMP‐2, MMP‐9, and PI3K/AKT pathway molecules in placental tissues was assessed by immunohistochemistry, qRT‐PCR, and western blot analysis. CircTNC overexpression inhibited cell invasion and migration, but did not influence cell proliferation. CircTNC bound with miR‐525‐5p, whose knockdown repressed cell invasion and migration, while it exerted no effect on cell proliferation. ABL1, a target of miR‐525‐5p, attenuated cell migration and invasion, without influence on cell viability. Importantly, either miR‐525‐5p overexpression or ABL1 depletion antagonized the repression of upregulated circTNC on trophoblast cell migration and invasion, MMP‐2 and MMP‐9 expression, and the PI3K/AKT pathway. CircTNC knockdown alleviated PE symptoms in pregnant mice. CircTNC knockdown promoted the trophoblast invasiveness in mice placenta by upregulating MMP‐2/9 expression and suppressing the PI3K/AKT pathway. Circ_0088196 represses trophoblast invasion and migration both in vitro and in vivo via regulating the miR‐525‐5p/ABL1 axis and activating the PI3K/AKT pathway.
Conformational preferences of endohedral metallofullerenes on Ag, Au, and MgO surfaces: Theoretical studies
Authors: Dubrovin Vasilii , Avdoshenko Stanislav M. 
Published: July 2022

AbstractIn this report, we study the ordering of C60, Sc3N@C80, and Dy2ScN@C80 molecules on different metallic and dielectric surfaces such as Ag(100), Au(111), and MgO(100). By using DFT techniques, we can classify different types of cage‐to‐surface arrangements and their relative energies. Using a proposed homogenous sampling of the conformational space for the M3N cluster, we determine a potential energy map that is capable of providing a structural distribution for a given energy window. We find that Coulomb interaction is a dominant force that governs the system's stability and order. However, a deep analysis of the charge density rearrangements reveals that even though the integral charges may be considered as a qualitative control parameter, it fails to provide quantitative data due to the importance of spatial characteristics of charge densities.
Using Endogenous Biomarkers to Derisk Assessment of Transporter‐Mediated Drug‐Drug Interactions: A Scientific Perspective
Authors: Arya Vikram , Reynolds Kellie S. , Yang Xinning 
Published: July 2022

AbstractComprehensive characterization of transporter mediated drug‐drug interactions (DDIs) is important to formulate clinical management strategies and ensure the safe and effective use of concomitantly administered drugs. The potential of a drug to inhibit transporters is predicted by comparing the ratio of the relevant concentration (depending on the transporter) and the half maximum inhibitory concentration to a predefined “cutoff” value. If the ratio is greater than the cutoff value, modeling approaches such as physiologically based pharmacokinetic modeling or a clinical DDI trial may be recommended. Because false‐positive (in vitro data suggest the potential for a DDI, whereas no significant DDI is observed in vivo) and false‐negative (in vitro data does not suggest the potential for a DDI, whereas significant DDI is observed in vivo) outcomes have been observed, there is interest in exploring additional approaches to facilitate prediction of transporter‐mediated DDIs. The idea of assessing changes in the concentration of endogenous biomarkers (which are substrates of clinically relevant transporters) to gain insight on the potential for a drug to inhibit transporter activity has received widespread attention. This brief report describes how endogenous biomarkers may help to expand the DDI assessment toolkit, highlights some current knowledge gaps, and outlines a conceptual framework that may complement the current paradigm of predicting the potential for transporter‐mediated DDIs.
“Ouch!” When and why food anthropomorphism negatively affects consumption
Authors: Schroll Roland 
Published: July 2022

AbstractAnthropomorphism is a widely used communication strategy—especially popular to promote food products. The current research examines the novel idea that food anthropomorphism negatively affects consumption—reducing consumption amount and deteriorating consumption experience. I argue and show that this negative effect occurs because anthropomorphizing grants the food product the perceived capacity to feel pain, which negatively affects consumption because it increases perceived immorality of consumption. In support of this process, I demonstrate that this negative effect manifests only among warm‐hearted (vs. cold‐hearted) consumers and in consumption (vs. purchase) decisions. Doing so not only extends anthropomorphism theory by providing a more nuanced understanding of how consumers respond to food anthropomorphism, but also allows to formulate managerial guidelines for the implementation of this strategy.
Adopting artificial intelligence in dental education: A model for academic leadership and innovation
Authors: Islam Nadim M. , Laughter Lory , Sadid‐Zadeh Ramtin , Smith Carlos , Dolan Teresa A. , Crain Geralyn , Squarize Cristiane H. 
Published: July 2022

AbstractIntroductionThe continual evolution of dental education, dental practice and the delivery of optimal oral health care is rooted in the practice of leadership. This paper explores opportunities and challenges facing dental education with a specific focus on incorporating the use of artificial intelligence (AI).MethodsUsing the model in Bolman and Deal's Reframing Organizations, the Four Frames model serves as a road map for building infrastructure within dental schools for the adoption of AI.ConclusionAI can complement and boost human tasks and have a far‐reaching impact in academia and health care. Its adoption could enhance educational experiences and the delivery of care, and support current functions and future innovation. The framework suggested in this paper, while specific to AI, could be adapted and applied to a myriad of innovations and new organizational ideals and goals within institutions of dental education.
Plasma carnitine concentrations in Medium‐chain acyl‐CoA dehydrogenase deficiency: lessons from an observational cohort study
Authors: Jager Emmalie A. , Schaafsma Merit , van der Klauw Melanie. M. , Heiner‐Fokkema M. Rebecca , Derks Terry G. J. 
Published: July 2022

AbstractOur aim was to study the effect of secondary carnitine deficiency (SCD) and carnitine supplementation on important outcome measures for persons with medium‐chain Acyl–CoA dehydrogenase deficiency (MCADD). We performed a large retrospective observational study using all recorded visits of persons with MCADD in the University Medical Center Groningen, the Netherlands, between October 1994 and October 2019. Frequency and duration of acute unscheduled preventive hospital visits, exercise tolerance, fatigue, and muscle pain were considered important clinical outcomes and were studied in relation to (acyl)carnitine profile and carnitine supplementation status. The study encompassed 1228 visits of 93 persons with MCADD. >60% had SCD during follow‐up. This included only persons with severe MCADD. Carnitine supplementation and SCD were unrelated to the frequency and duration of the acute unscheduled preventive hospital visits (P > 0.05). The relative risk for fatigue, muscle ache, or exercise intolerance was equal between persons with and without SCD (RR 1.6, 95% CI 0.48–5.10, P = 0.4662). No episodes of metabolic crisis were recorded in non‐carnitine‐supplemented persons with MCADD and SCD. In some persons with MCADD, SCD resolved without carnitine supplementation. There is absence of real‐world evidence in favor of routine carnitine analysis and carnitine supplementation in the follow‐up of persons with MCADD.
The structure and functional mechanism of eyespot in Chlamydomonas
Authors: Seth Kunal , Kumawat Geetanjali , Vyas Pallavi , Harish  
Published: July 2022

AbstractLight plays a crucial role in photosynthesis, photoperiodism, and photomorphogenesis. Algae have a specialized visual system to perceive the light signal known as eyespot. A typical eyespot is an orange‐colored, membranous structure packed with pigmented granules. In algae, the eyespot membrane bears a specialized type of photoreceptors, which shows similarity with animal rhodopsin photoreceptors. This light‐sensing receptor is responsible for the photo‐mobility response known as phototaxis. In this, light acts as a signal for onset and cascade of downstream signal transduction pathway leading to a conformational change in photoreceptor. This induces the continuous influx of calcium ions through the opening of calcium ion channels leading to membrane depolarization, and beating of flagella which is responsible for phototaxis. Mutational studies have assisted the discovery of eyespot genes, which are involved in eyespot development, assembly, size control, and functioning in Chlamydomonas. These genes belong to photoreceptors (cop1‐12, acry, pcry, cry‐dash1, cry‐dash2, phot, uvr8), eyeless mutants (eye2, eye3), miniature‐eyespot mutants (min1, min2), multiple eyespot mutants (mlt1, mlt2). This review discusses the structural biology of eyespots with special reference to Chlamydomonas, molecular insights, related genes, and proteins responsible for its proper functioning.
Long‐term effect of conservation agriculture on the composition and nutritional value of durum wheat grains grown over 2 years in a Mediterranean environment
Authors: Kerbouai Imene , M'hamed Hatem Cheikh , Jenfaoui Houda , Riahi Jouhaina , Mokrani Khaoula , Jribi Sarra , Arfaoui Slim , Sassi Khaled , Ben Ismail Hanen 
Published: July 2022

AbstractBACKGROUNDGiven the interest in mitigating the consequences of soil deterioration and climate change impacts on durum wheat grain, the objective of our study was to evaluate the effect of two soil management systems – conservation agriculture (CA) and conventional tillage (CT) – on the grain composition and nutritional value of two durum wheat varieties (Karim and Monastir) grown over two cropping seasons (2018–2019 and 2019–2020).RESULTSThe soil management system had an impact on all studied parameters, namely 1000‐kernel weight (TKW), proximate composition, energy value, total phenol content (TPC), antioxidant capacities (DPPH and ABTS) and mineral elements (K, P and Na), excluding hectoliter weight. CA resulted in high moisture content, crude protein, P, K, Na, TPC, DPPH and ABTS. However, TKW, crude fat, crude ash, energy value, and total carbohydrate were higher when using CT.CONCLUSIONA 2‐year adoption of conservation agriculture after a long‐term conversion enhanced some compositional parameters and nutritional value of durum wheat varieties. The interaction with year and/or variety was very influential. © 2022 Society of Chemical Industry.
Experience in utilizing a novel 3D digital model with CT and MRI fusion data in sarcoma evaluation and surgical planning
Authors: Du Xinhui , Wei Hua , Zhang Boya , Gao Shilei , Li Zhehuang , Cheng Yu , Fan Yichao , Zhou Xiaotian , Yao Weitao 
Published: July 2022

AbstractObjectiveTo assess sarcoma margins with more accuracy and aid surgical planning, we constructed three‐dimensional (3D) digital models with computed tomography(CT) and magnetic resonance imaging (MRI) image fusion data and validated the preciseness of the models by comparing them with 3D models constructed with CT only data.Materials and MethodsWe retrospectively reviewed a consecutive set of patients treated in our center who were preoperatively evaluated with the fusion image model. Models based on fusion images or CT‐only data were constructed. Volumes of both tumors were calculated and the tumors were overlapped to see the location of differences between the two models.ResultsA consecutive 12 cases (4 male vs. 8 female) were included in this study. Most of the tumors were located in the pelvic bone or spine. The volume of the two tumor models was different and the differences were mainly in the peripheral region of the tumor.ConclusionCT and MRI fusion image 3D models are more accurate than models with CT‐only data and can be very helpful in preoperative planning of sarcoma patients.
Interobserver Variability in Ultrasound‐Based Liver Fat Quantification
Authors: Şendur Halit Nahit , Cerit Mahi Nur , Ibrahimkhanli Nemat , Şendur Aylin Billur , Özhan Oktar Suna 
Published: July 2022

ObjectivesTo assess interobserver variability in ultrasound‐based quantitative liver fat content measurements and to determine how much time these quantitative ultrasound (QUS) techniques require.MethodsOne hundred patients with known or suspected of having nonalcoholic fatty liver disease were included in this prospective study. Two observers who were blinded to each other measurements performed tissue attenuation imaging (TAI) and tissue scatter distribution imaging (TSI) techniques independently. Both observers assessed hepatic steatosis visually and obtained 5 measurements for each QUS technique and the median values of the measurements were recorded. Spearman's correlation test was used to assess the correlation between QUS measurements and visual hepatic stetaosis grades. Intraclass correlation coefficient (ICC) test was used to assess interobserver variability in QUS measurements.ResultsThe median values of TAI measurements for the observers 1 and 2 were 0.75 and 0.74 dB/cm/MHz, respectively. The median values of TSI measurements for the observers 1 and 2 were 93.53 and 92.58, respectively. The interobserver agreement in TAI (ICC: 0.970) and TSI (ICC: 0.938) measurements were excellent. The mean of the required time period for TAI technique were 55.1 ± 7.8 and 59.9 ± 6.6 seconds for the observers 1 and 2, respectively. The mean of the required time period for TSI technique were 49.1 ± 5.8 and 54.1 ± 5.4 seconds for the observers 1 and 2, respectively.ConclusionThe current study revealed that both TAI and TSI techniques are highly reproducible and can be implemented into daily practice with little additional time requirement.
Quasi‐Bound States in the Continuum Enhanced Second‐Harmonic Generation in Thin‐Film Lithium Niobate
Authors: Zhang Xiaotian , He Linye , Gan Xin , Huang Xiaocong , Du Yixuan , Zhai Zhenshan , Li Zhuang , Zheng Yuanlin , Chen Xianfeng , Cai Yangjian , Ao Xianyu 
Published: July 2022

AbstractThis work reports the second‐harmonic generation (SHG) in a z‐cut thin‐film lithium niobate (LN) under nearly normal‐incident linearly‐polarized pumping. To utilize the largest nonlinear term which is along the out‐of‐plane direction in the z‐cut LN film, the film is patterned with a 2D periodic array to support symmetry‐protected bound states in the continuum (BICs) bearing strong out‐of‐plane electric field component. Enabled by such optical resonances near the BIC condition at the pumping wavelength, significant enhancement in SHG compared to an unpatterned film is observed. This approach, combining transparent thin‐film nonlinear materials with tailored BICs, offers prospects for engineering compact coherent light sources in a broad wavelength range.
On the logic of distributive nearlattices
Authors: González Luciano J. 
Published: July 2022

AbstractWe study the propositional logic associated with the variety of distributive nearlattices . We prove that the logic coincides with the assertional logic associated with the variety and with the order‐based logic associated with . We obtain a characterization of the reduced matrix models of logic . We develop a connection between the logic and the ‐fragment of classical logic. Finally, we present two Hilbert‐style axiomatizations for the logic .
Development of Molding Compounds Based on Epoxy Resin/Aromatic Amine/Benzoxazine for High‐Temperature Electronic Packaging Applications
Authors: Gou Haolan , Bao Ying , Huang Jiateng , Fei Xiaoma , Li Xiaojie , Wei Wei 
Published: July 2022

AbstractHeat‐resistant molding of compounds is an indispensable part in encapsulating future electronic power devices. Herein, it is used for polyfunctional epoxy resin (EP) and diamine‐phenol benzoxazine (BOZ) as resin matrix, 4,4'‐diaminodiphenylmethane (DDM) as curing agent, and iron acetylacetonate (Fe(acac)3) as curing accelerator, as well as inorganic fillers and other auxiliaries, to prepare heat‐resistant molding compounds. The curing behavior, processability and thermal performance of the EP/DDM/BOZ (EDB) resin blends containing different contents of DDM, BOZ, and Fe(acac)3are first systematically investigated. The EDB molding compounds (MCEDB) with suitable BOZ content show good processability, and the molding process can be compatible with that of commercial epoxy molding compounds (EMC). With increasing the BOZ content, the glass transition temperature of cured MCEDBis greatly enhanced to a maximum of 261 °C determined by dynamic mechanical analyzer, owing to the hydrogen‐bond interaction generated after polymerization of BOZ increasing the rigidity of network chains. Moreover, the cured MCEDBalso exhibits higher thermal decomposition stability, better high‐temperature (200 °C) mechanical properties, and lower water absorption compared to the cured EMC. After high‐temperature (200 °C) aging for 500 h, the cured MCEDBwith suitable BOZ content still maintains outstanding performance. This study provides a promising strategy for preparing heat‐resistant electronic packaging molding compounds.
Dual‐polarized frequency selective absorber with in‐band reflection response
Authors: Li Zhihang , Zhang Guanmao , Yang Shuo , Lun Yupeng , Che Zonge , Yue Juan , Suo Junhong 
Published: July 2022

AbstractThis paper proposes a frequency selective absorber with a notch reflection band. It consists of a lossy layer and a metal ground. The lossy layer is composed of the octagonal ring and meander‐line resonators connected in parallel on the same plane, which are used to obtain a wide absorption band and a notch reflection band, respectively. The simulation results show that there are two absorption bands from 2.22 to 6.8 GHz and 7.94 to 8.54 GHz, and there is a −3dB reflection band from 7.14 to 7.68 GHz. Moreover, the absorber also has the characteristics of compact structure, polarization‐independent, and angular stability. The equivalent circuit has been established and explained the performance of the proposed band‐notched absorber. The proposed band‐notched absorber is manufactured and measured, and the results are generally in good agreement with the full‐wave simulation results.