bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated analysis of clinical, bioelectrical and functional variables in newly diagnosed lung cancer adult patients: Pilot study
Authors: Regüeiferos Justa Carmen Justa Carmen Columbié , Luna Taira Teresa Batista , Brooks Soraida Cándida Acosta , Rodriguez Maylet Planas , Matamoros Larisa Zamora , Rodríguez Beatríz Legrá , Fernández Arnolis Poll , Bello José Luis García , Pedrón Arquímedes Montoya , González Maraelys Morales , Garcia Julio Cesar Núñez , Fonseca Esmirna Cascaret , Cabrales Luis Enrique Bergues 
Published: May 2022

Abstract
Background
Many variables have been studied in cancer patients. Nevertheless, an study that analyzes simultaneously physical, functional and biological variables in they from clinical, physical and statistical points of views is not reported in the literature. The aim of this study is to propose an integrated analysis of clinical, bioelectrical and functional variables in newly diagnosed lung cancer adult patients for the integral evaluation and possible prognostic of them.
Methods
This Pilot study was retrospective and cross-sectional and 23 patients aged 53–82 years participated in it. The electrical resistance and capacitive electrical reactance were measured with the Bodystat Quadscan® 4000 analyzer. The electrical impedance modulus and the phase angle were calculated. The serum concentrations of epidermal growth factor, CYFRA21-1 and CA 72 − 4 were quantified. Correlations/associations among variables and the principal component analysis were suggested.
Results
The majority of patients had tumor markers, electrical resistance and the phase angle in their respective normal ranges. The capacitive electrical resistance was below its normal range. Minimum, low and moderate grades of linear correlation/association prevailed among studied variables. The principal components I and II were interpreted as prognosis and body energetic reserve of the patient, respectively.
Conclusions
It is concluded that the clinical, bioelectrical and functional variables allow the integral analysis and possible prognosis of newly diagnosed lung cancer adult patients. The decrease of the capacitive electrical reactance is the most influence to the loss of the body energetic reserve that leads to alterations of the overall health, tiredness and decrease of weight and body mass index of these patients.
Assessment of Possible HPV Association in Colorectal Cancer
Authors: Khan Saifullah , Hayat Azam , Khan Ibrar , Rehman Mujaddad 
Published: May 2022

Abstract
Purpose of current study was to investigate HPV role in colorectal cancer development. The human papillomavirus (HPV) is one of the most prevalent sexually transmitted viruses, and its link to cancers of the cervix, penis, vulva, vagina, anus, and oropharynx has been well reported. Persistent infections can lead to premalignant and malignant tumours and HPV infection is responsible for about 4.8 percent of all malignancies worldwide. During this study a total of 135 histopathologically confirmed cancer paraffin embedded biopsy specimens were collected from different hospitals of Hazara division. These specimens were re-examined in histopathology lab for confirmation. Majority of samples were confirmed as Adenocarcinoma in various colon locations, rectal squamous carcinoma and colon adenoma.10 normal biopsy specimens without any abnormality was taken as controls. These specimens were processed in Abbot lab and after treating with liquid nitrogen specimens were subjected to GeneXpert PCR system for the detection of HPV DNA along with high risk genotypes (HPV-16, 18 and 45) of HPV DNA. There was no HPV DNA detection in all control specimens. Out of 135 specimens 85 (62%) were detected with HPV DNA 37 (43%) with HPV-16, 25(29%) with HPV-18 and 16(19%) with HPV-45 genotype. Seven specimens were detected with low risk genotypes
Life-threatening event after injection laryngoplasty in a patient with chemotherapy-induced vocal-fold motion impairment: A case report
Authors: Jeon Seung Yeon , Gong Soo Jung , Yoon Ra Gyoung , Jung Ah Ra 
Published: May 2022

Abstract
Background: Although chemotherapy-induced vocal-fold motion impairment was first reported in 1971, there are few reports. Herein, we describe a case in which life-threatening side effects occurred after injection laryngoplasty for the treatment of chemotherapy-induced vocal-fold motion impairment accompanied by dysphonia and aspiration in a patient with lymphoma.Case presentation: An 86-year-old woman with diffuse large B-cell lymphoma developed left vocal fold immobility with dysphonia and aspiration after six cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy. The patient underwent injection laryngoplasty to prevent aspiration pneumonia approximately 5 h after the 7th cycle of chemotherapy. On the 3rd day after the procedure, she visited the emergency room with swelling of the anterior neck and dyspnea with stridor, which had gradually worsened since the previous day, and emergency hematoma removal was performed. On the 14th day after injection laryngoplasty, laryngeal examination performed to observe the vocal cord bruises revealed improvement of edema. Dyspnea and dysphonia observed before emergency surgery resolved completely one month after the operation.Conclusions: It is important to promptly evaluate patients with symptoms such as dyspnea and stridor after injection laryngoplasty and select a safe procedure time for patients receiving chemotherapy to avoid serious complications, such as hematomas.
Sporadic amyotrophic lateral sclerosis: integral model of pathogenesis and therapy options
Authors: Doroshenko Oleksii 
Published: May 2022

Abstract
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive central nervous system degenerative disease, in most cases within 2–3 years inevitably leading to mixed tetraplegia and subsequent death from diaphragmatic paralysis. While for almost half of hereditary cases, mutations are identified as the cause of the disease, the sporadic form of ALS (sALS), due to the polymorphism and complexity of the putative developmental mechanisms raises a lot of questions. To date, there are no sufficiently effective pathogenetic methods for the disease treatment. All the above mentioned makes ALS one of the most relevant and, at the same time, unexplored topics in neurology. In this review, the author combines the most important, in our opinion, currently known factors of sALS pathogenesis, including Coxsackievirus B3 (CVB3) – the infection, TAR DNA binding protein 43 (TDP-43) pathology, human endogenous retrovirus-K (HERV-K) reactivation, RNA-specific editase 1 (ADAR2) dysfunction and oxidative stress (OS) into a unified illustrative model. The author is suggesting a probable sequence of pathogenetic links, based on data regarding the presence of pathophysiological links between them and their ability to cause the typical for sALS histochemical pattern. Simultaneously, the author makes assumptions about the developmental mechanisms for some secondary disorders typical for sALS. In conclusion, in accordance with the derived model, the author conducts a review of possible pharmacological interventions of pathogenetic and etiotropic therapy. The author describes both clinically proven effective drugs, and previously unstudied, but extremely promising compounds that require further testing.
Hsa-miR-1248 suppressed the proliferation, invasion and migration of colorectal cancer cells via inhibiting PSMD10
Authors: Wang Chengxing , Wang Bin , Liang Weijun , Zhou Chaorong , Lin Weixing , Meng Zijie , Wu Wanting , Wu Meimei , Liao Yuehua , Li Xiaoping , Zhao Jinglin , He Yaoming 
Published: May 2022

Abstract
Background.
Lymph node metastasis (LNM) is a critical event during the colorectal cancer (CRC) development and is indicative of poor prognosis. Identification of molecular markers of LNM may facilitate better therapeutic decision-making.
Methods.
Six pairs of CRC tissues and corresponding adjacent tissues [3 pairs diagnosed as pT1N0M0 (M_Low group) and 3 pairs diagnosed as pT4N2M0 (M_High group)] collected from CRC patients who underwent surgical resection were used. MicroRNA sequencing was performed to screen differential microRNAs involved in CRC LNM. The selected microRNAs were validated in CRC tissue and cell lines using qRT-PCR. The functions of candidate miR-1248 were evaluated by CCK-8, colony formation, and Transwell assay. The binding of miR-1248 with its target PSMD10 was confirmed by luciferase activity assay, and the expression of PSMD10 in tissues was detected by droplet digital polymerase chain reaction.
Results.
Ninety-five miRNAs were downregulated in carcinoma tissue (M_Low and M_high groups) compared with Normal group. Their expression in M_High group was significantly lower compared with M_Low group. The top3 were hsa-miR-635, hsa-miR-1248, and hsa-miR-668-3p. After validation in tissues/cell lines, only hsa-miR-1248 was decreased in high metastatic tissues or SW620 cells compared to low metastatic tissues or SW480 cells. hsa-miR-1248 was found to inhibit CRC cell viability, proliferation, invasion, and migration. The tumor suppressor effect of miR-1248 in CRC cells was attenuated or enhanced by up-regulating or down-regulating PSMD10, respectively.
Conclusion.
miR-1248 may act as a tumor suppressor gene in CRC by targeting and inhibiting PSMD10, which provides a clue for CRC treatment.
Changes of autonomic nervous system activity on idiopathic premature ventricular complexes after radiofrequency ablation
Authors: Ding Bing , Dai Yunlang , Zhang Fangfang , Hui Jie , Chen Yunhu , He Linyan , Xie Liqian 
Published: May 2022

Abstract
Objective Radiofrequency catheter ablation (RFCA) is a standard treatment for idiopathic premature ventricular complexes (PVCs). This study was aimed to determine autonomic nervous system (ANS) activity in patients with low, medium and high PVC burdens pre- and pro-RFCA. Methods We retrospectively analyzed a total of 200 patients underwent radiofrequency ablation surgery for idiopathic PVCS from June 2017 to March 2021. The procedural ablation success was achieved in 179 of the 200 (89.5%). Patients had success ablation was classified into low burden PVC group (PVCs/min ≤15%), medium burden PVC group (15%> PVCs/min <25%) and high burden PVC group (PVCs/min ≥25%). We assessed the clinical data, time and frequency-domain variables, heart rate turbulence(HRV) and deceleration capacity of rate of patients with different PVC burdens and various ablation site. Spearman correlation analysis was performed.Results High burden PVCs had higher mean HR, SDANN, SDNN index, standard deviation of normal to normal intervals (SDNN), root-mean square successive differences (rMSSD), pNN50 and lower ratio of low-frequency (LF)/ high-frequency (HF), compared to low burden PVCs. After ablation, SDNN, SDNN index, SDANN, rMSSD, pNN50, TS (turbulence slope) and DC (deceleration capacity) were significantly decreased (P<0.01), while LF/HF and TO was significantly increased (P<0.01). The burden of preoperative PVCs was positively correlated with LVD, mean HR, SDNN index, SDANN, rMSSD and pNN50, but negatively correlated with TC, LDL-C, LVEF and LF/HF. Regression analysis showed that the burden of PVCs was positively correlated with mean HR (P=0.000), SDANN (P=0.000) and rMSSD (P=0.000).Conclusion With the increase of PVCS burden, both sympathetic and vagus nerve activities are enhanced. The numbers of PVCS may be related to impaired autonomic nerve balance regulation. RFCA reduced parasympathetic activity and sympathetic activity after eradication of PVCS.
Effect of irrigation water level and Frequency on Tomato (Lycopersiconesculentum) in lowland area of Ethiopia
Authors: Nigatu Belihu , Getu Demisew , Getachew Tsegaye , Getaneh Biruk 
Published: May 2022

Abstract
Irrigation water level and frequency for crops is vital for irrigation water management and planning. Irrigation regime is planning when and how much water to apply to maintain healthy plant growth during the growing season. However, in the study area the amount of irrigation and frequency application is not properly determine and the farmers has lacked knowledge how much water applied to tomato crops in the lowland area of north shewa. Therefore, this study is to determine the irrigation level and frequency for tomato vegetable. The experiment was conducted in a randomly completed block design with three replication using 15 treatments where 150%Etc, 125%Etc, 100%Etc, 75%Etc, and 50%Etc water level and three irrigation interval. The results indicated that marketable fruit yield, total fruit yield, water use efficiency and plant height were significant (P < 0.05) affected by irrigation regime. The highest yield was 54.49 t/ha while the lowest was 37.89 t/ha. Statically 48.5 t/ha yield in the amount of irrigation water 376.71 mm depth with the water use efficiency 10.79 kg/m 3 and safe 3127.33m3 water from one hectare and get 0.59 ha additional irrigation land. The application of water in each stage was initial 33.64 mm with 5 days interval, development-one 60.54 mm with 9 days interval, development-two 94.18 mm, mid 94.18 mm and late 94.18 mm with 14 days interval water application used. Therefore, the total depth of the water during the growth period of tomato at the study area is applied 4431.94m3/ha to get 48.95t/ha tomato yield gave an additional irrigation land.
Preparation of bio-based adsorbent from waste tomato stem and used as photocatalyst for Basic Red 2 photocatalysis
Authors: Eskikaya Ozan , Arslan Hudaverdi , Gun Melis , Bouras Hadj Daoud , Dizge Nadir 
Published: May 2022

Abstract
Many natural substances contain calcium oxide (CaO), which is found in their basic structure. Due to its excellent structure and non-toxic properties, it is a potential element in the field of environmental management. The photocatalytic activity of bio-based catalyst synthesized from waste tomato stem (WTS) containing CaO (WTS-CaO) was examined in this study. This study is unique in that it uses a photocatalyst made from waste tomato stems to remove dye in a photocatalytic system. Characterizations of WTS-CaO were obtained using FTIR, XRF, SEM, and EDX analyses methods. In photocatalytic tests, the effects of light source, photocatalyst dosage, pH, and dye concentrations on dye removal efficiency was investigated at 90 min. In addition, the samples were subjected to sintering operations at temperatures of 900oC in order to examine the synthesis of CaO from waste tomato stem. Basic Red 2 (Safranin) which is a cationic dye was used in the photocatalytic experiments. The above parameters were determined to be optimal for photocatalytic studies done: 0.5 g/L catalyst dosage, 5 mg/L dye concentration, reuse of catalyst, amount of H2O2 and original solution pH under visible light.
Radiation-induced fibrosarcoma after breast-conserving surgery and radiation therapy for breast cancer: A case report and literature review
Authors: Hoshina Hideko , Kubouchi Kouichi , Tsutsumi Yutaka , Takei Hiroyuki 
Published: May 2022

Abstract
Background
Radiation-induced sarcoma (RIS) has a 10-year incidence of 0.2–0.27% and a poor prognosis. In particular, radiation-induced fibrosarcoma has been rarer, and its incidence is 2.6–3.7% of RIS.
Case presentation:
A 43-year-old woman with pT1N1M0 breast cancer underwent breast-conserving surgery, chemotherapy, radiation therapy eight years ago, and continued hormonal therapy. She complained of a hard mass palpated in her right axillary breast. Although we suspected local recurrence, core needle biopsy revealed atypical spindled tumor cells without mammary or epithelial markers. A diagnosis of fibrosarcoma was made via tumorectomy. She underwent additional enlarged surgery.
Conclusions
We report a rare case of fibrosarcoma after breast-conserving surgery and radiation therapy. Fibrosarcoma after radiation therapy for breast cancer has been reported in 30 cases, including the present case. The dead and alive cases were not significantly different in terms of age, primary breast cancer, radiation dose, and following months. Patients with breast masses after radiation therapy should be suspected local recurrence and RIS.
Design, synthesis of Dioxopiperidinamide derivatives by amide coupling reaction and study of their biological activity
Authors: Kaliraj S , Jeyalakshmi R 
Published: May 2022

Abstract
A series of fifteen dioxopiperidinamide derivatives synthesized and their spectra chemical data were reported. An alternative amide coupling reaction has been followed by using 3-aminopiperidine-2,6-dione through amide bond functionalization between N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC.HCl) and Hydroxybenzotriazole (HOBt). All the designed compounds were docked in to the active sites of 2A73: Human Complement Component C3. All the docked compounds is favorable to make both hydrogen and hydrophobic interaction with amino acids located at the binding site. The most of potential compounds 4g, 4h and 7 studied for their anticancer activity on the THP-1 cancer cells line. It was also further established their Anti-inflammatory activity and Antioxidant activity with the comparable efficiency against those of clinically used drugs.
High Stability of Ti3C2Tx MXene in PDLC-Based Energy Efficient Smart-Windows
Authors: Kumar Sunil , Park Hyun Min , Nguyen Huy , Kim Minwook , Nasir Naila , Kumar Manjeet , Seo Yongho 
Published: May 2022

Abstract
Among recently discovered MXenes, Ti3C2Tx MXene is the most popular candidate. But despite having many unique properties, its stability against oxidation is a major hurdle in its applications as it is easily oxidized under ambient conditions. To exploit the Ti3C2Tx MXene applicability, the stability against oxidation needs to be improved. In this study, we have found an application of Ti3C2Tx MXene in polymer-dispersed liquid crystals (PDLC) based smart-windows which do not require additional treatment to MXene for preventing its oxidation. Before this application, the MXene surface passivation by a thin layer of UV-curable polymer NOA65 was also studied for long-term stability against oxidation. After polymer passivation, the stability of MXene was found to improve significantly as compared to the non-passivated MXene. In polymer passivated MXene, the sheet resistance increases by just 20% as compared to 800% in case of non-passivated counterpart as studied up to 180 days. During this period, the transmittance of polymer passivated MXene film remains almost the same. These results encouraged the use of MXene-coated glass substrates in PDLC-based smart-window applications. The polymer used in smart-windows fabrication not only encapsulates the liquid crystals, but it also preserves the MXene without any additional treatment to MXene surface. The conducting MXene electrode and PDLC-based smart-windows maintain high transmittance of around 71% after 180 days as compared to 74% on day 1 at a voltage of 50 V. The switch-ON time of the fabricated smart-window is <1 microsecond.
The analysis of body shape and application in Caenorhabditis elegans behavior and state classification
Authors: Li Ning , Chen Weiyang 
Published: May 2022

Abstract
Background：The changes of motor behavior of worms largely reflect the internal activities of the nervous system. At present, the automatic analysis of worm’s movement is a rapidly developing field. A new method is needed to parameterize the shape of worm, so as to digitally describe and reconstruct the shape of worm body in low dimensional space, and better analyze the differences of worm’s movement and behavior.Results: This paper presents a new method of worm shape representation, extraction and reconstruction based on video sequence data. Firstly, the head position is recognized according to the morphological characteristics of worms, and the head position information is saved in the matrix; Secondly, according to the principle of equal division of arc length, the nematode is divided into 60 equal parts, and the angle between each arc length and the horizontal plane is calculated to form a mathematical vector of shape; Thirdly, the shape of worms in each frame is reconstructed according to the angle vector, distributed and stacked on the time axis to form the analysis model of worm behavior. It is proved that the algorithm has great advantages in shape extraction and reconstruction. In addition, the angle vector of continuous time series was used as the behavior characteristics of worms, combined with the traditional motion characteristics to analyze and identify the motion differences between different strains of C.elegans .Conclusions: The algorithm can represent the shape of the worm trunk extracted from the motion video. Moreover, each frame image in the video was distributed and stacked on the time axis to form the motion behavior analysis model of model organisms. It can be used to compare and analyze the changes of worm behavior and body posture, to analyze different strains of worms and classify worm's state. The code is freely available at: https://github.com/stone00stone/worm-analysis.
Centre of pressure during walking after unilateral transfemoral amputation
Authors: Ichimura Daisuke , Hisano Genki , Murata Hiroto , Kobayashi Toshiki , Hobara Hiroaki 
Published: May 2022

Abstract
Lower-limb amputation imposes a health burden on amputees; thus, gait assessments are required prophylactically and clinically, particularly for individuals with unilateral transfemoral amputation (UTFA). The centre of pressure (COP) during walking is one of the most useful parameters for evaluating gait. Although superimposed COP trajectories reflect the gait characteristics of individuals with neurological disorders, the quantitative characteristics based on the COP trajectories of individuals with UTFA remain unclear. Thus, these COP trajectories were investigated across a range of walking speeds in this study. The COP trajectories were recorded on a split-belt force-instrumented treadmill at eight walking speeds. Asymmetry and variability parameters were compared based on the COP trajectories of 25 individuals with UTFA and 25 able-bodied controls. The COP trajectories of the individuals with UTFA were significantly larger in lateral asymmetry and variability but did not show significant differences in anterior–posterior variability compared with those of the able-bodied controls. Further, the individuals with UTFA demonstrated larger lateral asymmetry at lower speeds. These results suggest that (1) individuals with UTFA adopt orientation-specific balance control strategies during gait and (2) individuals with UTFA could also be exposed to a higher risk of falling at lower walk speeds.
Revisiting ecohydrological separation
Authors: Zhao Ying , Orlowski Natalie , Wang Yi , Liu Jinzhao 
Published: May 2022

Abstract
The ecohydrological separation (EHS) paradigm, frequently compared with the translatory flow (HH), opens up a new understanding of terrestrial water cycles. Recent finding of cryogenic vacuum extraction (CVE) bias and associated correction no longer supports the EHS but goes back to HH. However, we found systematic similarities in plant and soil water lines for a global database, whereby the CVE-bias correction may not shift the EHS and/or HH.