bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of 2D Photonic Crystal Biosensor to Detect Blood Components
Authors: Parandin Fariborz , heidari farsad , Aslinezhad Mehdi , Roshani Sobhan , Roshani Saeed 
Published: April 2022

Abstract
Photonic crystals are periodic structures made of insulators. They are the best option to design biosensors. In this paper, a photonic crystal biosensor containing insulation rods in the air was designed and simulated. This biosensor was used as a photonic crystal circular nano-ring between the internal and external waveguides. At the end of the internal waveguide, a defect exists to create an increase in the coupling distance. This causes the quality factor and resonant wavelength displacement to increase. The purpose of designing this sensor is to check blood ingredients. After connecting to a measuring rod, this sensor shows different refractive indices. Another important characteristic of the proposed structure is that mostly radiuses of dielectric rods are identical. This causes the sensor construction to be easy. The plane-wave expansion (PWE) method is utilized to calculate the band structure. The results show that a photonic band gap (PBG) with a wavelength from 1.26 \(\mu m\) to 1.92 \(\mu m\) is created in this distance where no wavelength can spread.
Using a graph-based image segmentation algorithm for remote vital sign estimation and monitoring
Authors: Yang Xingyu , Zhang Zijian , Huang Yi , Zheng Yalin , Shen Yaochun 
Published: April 2022

Abstract
Reliable and contactless measurements of vital signs, such as respiration and heart rate, are still an unmet need in clinical and home settings. Mm-wave radar and video-based technologies are promising, but currently, the signal processing-based vital sign extraction methods are prone to body motion disruptions or illumination variations in the surrounding environment. Here we propose an image segmentation-based method to extract vital signs from the recorded video and mm-wave radar signals. The proposed method analyses time-frequency spectrograms obtained from Short-Time Fourier Transform rather than individual time-domain signals. This leads to much-improved robustness and accuracy of the heart rate and respiration rate extraction over existing methods. The experiments were conducted under no- and post-exercise conditions and repeated on multiple individuals. The results are evaluated by using four metrics against the gold standard contact-based measurements. Significant improvements are observed in terms of precision, accuracy, and stability. We believe that the proposed estimation method will help address the need for the increasingly popular remote cardiovascular sensing and diagnosing posed by Covid-19.
Analysis of the Mediating Role of Psychological Empowerment between Perceived Leader Trust and Employee Work Performance
Authors: LIU Xiaoli , REN Xiaopeng 
Published: April 2022

Abstract

High levels of trust between employees and leaders moderate the relationship between organizational management practices. A collaborative environment encourages employees to have more Psychological Empowerment, which in turn leads to better performance. Based on Intrinsic Work Motivation and Self-Evaluation, this paper uses Perceived Leader Trust as an independent variable, Employee Work Performance as a dependent variable, and introduces Psychological Empowerment to explore the internal mechanism of perceived trust. This paper proposes a total of 28 hypotheses, and 25 hypotheses have been verified. The specific research conclusions are as follows: (1) Perceived Leader Trust has a positive impact on Employee Work Performance. (2) Perceived Leader Trust positively affects employees' Psychological Empowerment. Perceived Leader Dependence has a significant impact on all dimensions of Psychological Empowerment, but the relationship between Perceived Information Disclosure and Work Meaning is not significant. (3) Psychological Empowerment is positively correlated with Employee Work Performance, in which the four dimensions of Psychological Empowerment are significantly related to Employee Task Performance, while Work Meaning and Autonomy are not significantly related to Employee Relationship Performance. (4) Psychological Empowerment, as the overall perception of employees, plays a partial mediating role between Perceived Leader Trust and Employee Work Performance. This paper verifies the role of Psychological Empowerment between Perceived Leader Trust and Employee Work Performance, and explores the internal mechanism of Perceived Leader Trust from the perspective of employees' Intrinsic Work Motivation, which promotes the development of organizational management practices.
Autotoxicity of Ambrosia artemisiifolia and Ambrosia trifida and its significance for the regulation of intra-species populations density
Authors: Su Pei , Liu Xuelian , Wang Ruili , Liu Tong , Zhao Wenxue , Sun Mingming , Wang Hanyue , Liu Yunxiao , Wu Qiang 
Published: April 2022

Abstract
Ambrosia artemisiifolia and Ambrosia trifida are annual invasive plants that cause serious harm to agriculture, animal husbandry, and human health. Based on the important characteristic of high-density, cluster distribution of their populations, it is speculated that its autotoxins have an effect on density regulation. This study explored the regulation of autotoxicity on intra-species density. We used water extracts from two plants to compare and verify the autotoxicity of seed germination, analysed the components of autotoxins. The results showed that A. artemisiifolia and A. trifida had significant autotoxicity, and the highest inhibition rates on seed germination were 27.21% and 77.94%, respectively; Ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS) analysis revealed that chlorogenic acid, caffeic acid, p-coumaric acid, and vanillin were the main autotoxins of the two plants. After the seeds were washed with water, the germination recovere rate of seeds increased with the increased of inhibition degree of autotoxins treatment. Therefore, this study verified the autotoxicity of A. artemisiifolia and A. trifida, which can promote and inhibit the seed germination of A. artemisiifolia and A. trifida to regulate intra-specific competition.
Epidermal Microbiomes of Leopard Sharks (Triakis semifasciata) Are Consistent Across Captive and Wild Environments
Authors: Goodman Asha Z. , Papudeshi Bhavya , Doane Michael P. , Johnson Colton , Mora Maria , Kerr Emma , Torres Melissa , Moffatt Jennifer , Lima Laís Farias Oliveira , Nosal Andrew , Dinsdale Elizabeth 
Published: April 2022

Abstract
Characterizations of sharks-microbe systems in wild environments have outlined patterns of species-specific microbiomes; however, whether captivity affects these trends has yet to be determined. We used high-throughput shotgun sequencing to assess the epidermal microbiome belonging to leopard sharks (Triakis semifasciata) in captive (Birch Aquarium, La Jolla California born and held permanently in captivity), semi-captive (held in captivity for <1 year in duration and scheduled for release; Scripps Institute of Oceanography, California) and wild environments (Moss Landing and La Jolla, California). Here we report captive environments do not drive epidermal microbiome compositions of T. semifasciata to significantly diverge from wild counterparts as life-long captive sharks maintain a species-specific epidermal microbiome resembling those associated with semi-captive and wild populations. Major taxonomic composition shifts observed were inverse changes of top taxonomic contributors across captive duration, specifically an increase of Pseudoalteromonadaceae and consequent decrease of Pseudomonadaceae relative abundance as T. semifasciata increased duration in captive conditions. Moreover, we show captivity did not lead to significant losses in microbial α-diversity of shark epidermal communities. Finally, we present a novel association between T. semifasciata and the Muricauda genus as Metagenomes associated genomes revealed a consistent relationship across captive, semi-captive, and wild populations. Since changes in microbial communities is often associated with poor health outcomes, our report illustrates that epidermally-associated microbes belonging to T. semifasciata are not suffering detrimental impacts from long or short-term captivity. Therefore, conservation programs which house sharks in aquariums are providing a healthy environment for the organisms on display. Our findings also expand on current understanding of shark epidermal microbiomes, explore the effects of ecologically different scenarios on benthic shark microbe associations, and highlight novel associations that are consistent across captive gradients.
Feasibility of a nonlinear spectral approach for peak floor acceleration of multi-story bilinear hysteretic buildings
Authors: Xiang Yang , Zhang Yu-Jian , Xu Fei , Li Guo-Qiang 
Published: April 2022

Abstract
To protect the acceleration-sensitive non-structural components in a multi-story building, a proper seismic design of them against the peak floor acceleration (PFA) is needed. The PFA, therefore, should be estimated in advance. To efficiently estimate the PFA of multi-story buildings at the inelastic stage, a nonlinear modal combination approach is provided in this study. First, for the single-story building (single-degree-of-freedom system), a PFA spectral ratio δ is proposed to measure the nonlinear reductions in PFA. A series of time history analysis (THA) revealed that there is a dependable relationship between the PFA spectral ratio δ, the strength reduction factor R, the post-yield stiffness ratio α, and the period T of the structure. The scatter of δ is notably smaller than the ductility demand, showing the good feasibility of a δ-R-T-α relationship for predicting δ. Second, for the multi-story building (multi-degree-of-freedom system), the floor acceleration is decoupled in the modal space, the contribution of each mode to the elastic PFA is multiplied by δ to account for the nonlinear reduction in PFA at the inelastic stage. Here δ can be determined by an appropriate δ-R-T-α relationship, while R and α are determined via a modal pushover analysis. The modified modal contributions are combined via the complete-quadratic combination (CQC) rule, forming the modified CQC (MCQC) approach. The PFAs of some 2-, 5-, and 8-story building structures with different degrees of nonlinearity are computed via the THA and the MCQC approach. The results demonstrate the satisfactory accuracy of the MCQC approach. Notably, the effects of nonlinearities associated with the higher-order modes on the nonlinear PFA are well considered in the MCQC approach, thus the un-acceptable over-estimations of the inelastic PFA, which occurs in conventional methods, are avoided.
Conjugates of Pyropheophorbide α with 17-substituted Steroidal Androgens. Synthesis, Molecular Modeling, Interaction with Some Cancer Cells
Authors: Zolottsev Vladimir , Korolchuk Andrei M. , Lukin Artyom S. , Morozevich Galina , Mekhtiev Arif R. , Novikov Roman. A. , Tkachev Yaroslav V. , Suvorov Nikita V. , Misharin Alexander Y. , Ponomarev Gelii V. 
Published: April 2022

Abstract
Five new bifunctional conjugates of pyropheophorbide a with 17-substituted testosterone, dihydrotestosterone and epitestosterone differing in the length of linker (1–5) and two new complex conjugates 6 and 7 (containing three functional units: pyropheophorbide a, 17α-substituted testosterone, and lipophylic hexadecyl chain) were synthesized. Mutual influence of steroidal and macrocyclic fragments in conjugates 1–7 was established by analysis of 1H NMR spectra and molecular models of conjugates. The uptake and internalization of conjugates 1–5 by prostate carcinoma cells were dependent on the stereochemical configuration of 17-hydroxyl group in steroidal moiety, and the length of linker. Conjugates 1–5 significantly decreased the LNCaP and PC-3 cells growth and proliferation at 96 h incubation; the anti-proliferative activity of epitestosterone derivative comprising short linker 3 was superior. Irradiation of cells labeled with conjugates with light (λ = 660 nm) significantly increased cytotoxicity. Trifunctioal conjugates 6 and 7 easily formed mixed micells with phosphatidyl choline and pluronic F68; these mixed micelles efficiently internalized by human hepatocarcinoma Hep G2 cells, herewith the internalization was dependent on the conjugate structure, rather than on the method of solubilization.
Effects of different doses of oxytocin on neonatal instinctive behaviors and breastfeeding: a prospective study
Authors: Wang Aihua , Zhou Yun , Liu Wenwen , Xu Yang , Zhang Xiaoyan , Miao Yiqun , Zhang Yuanyuan 
Published: April 2022

Abstract
Background: Oxytocin is the current domestic first-line agent of induced labor and labor augmentation, and its potential effects on neonatal neurobehavioral development is currently attracting increased attention.Objective: To explore the effect of different doses of synOT on neonatal instinctive breastfeeding behavior and breastfeeding by observing neonatal behaviors during SSC with mothers after delivery.Methods: A total of 154 pairs of pregnant women and their newborns were selected by random sampling. Observations and comparisons of neonatal instinctive behaviors were conducted by using the Widström's 9 Stages method.According to the dosage of oxytocin, subjects were divided into a low dose group (2.5 U) of 39 pairs, a medium dose group (≥ 5 U) of 38 pairs, a high dose group (≥ 10 U) of 38 pairs and a control group (no synOT use) of 39 couples. The occurrence time of newborns' instinctive movements and the duration time of each behavior stage for the four groups were also analyzed.The frequency of exclusive breastfeeding within 3 days after birth and the rate of exclusive breastfeeding at 3 months were collected and compared.Results: The intrapartum administration of synthetic oxytocin affects the expression of neonatal instinctive breastfeeding. With increases in drug dose, the effect of breast seeking activity and breast attachment will be more significant, and the effect of oxytocin on sucking and breastfeeding was dose-dependent.Conclusions: Intrapartum exposure to the different doses of synOT could affect the neonatal instinctive behaviors during skin-to-skin contact within two hours after birth to varying degrees, there were also adverse effects on the initiation and continuation of postpartum breastfeeding, with dose-dependent results.
Epidemiology of Human Adenovirus in children hospitalized with Community-acquired Gastroenteritis under the age of five years
Authors: Khan Nazif Ullah , Shamsullah  , Shahidullah  , Shah Aamir Ali , Zaidi Sayed Sohail Zahoor , Chen Zhi 
Published: April 2022

Abstract
Background: Acute gastroenteritis is the major cause of morbidity and mortality among infants and children around the globe. Along with other enteropathogens, human adenoviruses (HadV) are considered a major etiological agent associated with diarrhea in young children. However, information about the epidemiology of adenoviruses in Rawalpindi and Lahore, the two cities of Punjab province, Pakistan is not reported yet.Methods: A total of 384 fecal samples were negative for rotavirus, out of 1082 from a patient with acute gastroenteritis, under the age of five years with symptoms like watery diarrhea, visiting Benazir Bhutto hospital Rawalpindi and Children hospital Lahore were enrolled in this study. Human adenoviruses were tested for primary isolation in the human epithelial HEp-2 cell line. Furthermore, adenovirus antigen detection was carried out by enzyme-linked immunosorbent assay (ELISA), and then all the positive and negative samples were confirmed by nested PCR.Results: After inoculation stool, supernates on HEp-2 cell lines showed a positive cytopathic effect in 65 (16.) patients. Using an enzyme immunosorbent assay HAdV, antigens were detected in 54 (14.06%) samples. However, HAdV hexon coding regions were amplified in 57 (14.80%) fecal samples mostly from patients equal to or under 24 months of age.Conclusion: The findings of this study revealed that adenovirus is the etiological agent of gastroenteritis in the mentioned cities and provides the baseline data about the possible role of adenovirus in causing diarrhea in children. Further large-scale epidemiological surveys are required for a better understanding of disease burden and its clinical impact.
Chronic liver disease and hepatic calcium-oxalate deposition in patients with primary hyperoxaluria type I
Authors: Recker Pia , Beck Bodo Bernhard , Sikora Przemyslaw , Göbel Heike , Kemper Markus Josef , Nazco Angel , Martin-Higueras Cristina , Hoppe Bernd 
Published: April 2022

Abstract
Patients with primary hyperoxaluria type I (PHI) are prone to develop early kidney failure. Systemic deposition of calcium-oxalate (CaOx) crystals starts, when renal function declines and plasma oxalate (Pox) increases. All tissue, but especially bone, heart and eyes are affected. However, liver involvement, as CaOx deposition or chronic hepatitis/fibrosis has never been reported. We examined liver specimen from 19 PHI patients (aged 1.5 to 52 years at sample collection), obtained by diagnostic biopsy (1), at autopsy (1), or transplantation (17). With polarization microscopy, birefringent CaOx crystals located in small arteries, but not within hepatocytes were found in 3/19 patients. Cirrhosis was seen in one, fibrosis in 10/19 patients, with porto-portal and nodular fibrosis (n=1), with limitation to the portal field in 8 and/or to central areas in 5 patients. Unspecific hepatitis features were observed in 7 patients. Fiber proliferations were detectable in 10 cases and in one sample transformed Ito-cells (myofibroblasts) were found. Iron deposition, but also megakaryocytes as sign of extramedullary erythropoiesis were found in 9, or 3 patients, respectively. Overall, liver involvement in patients with PHI was more pronounced, as previously described. However, CaOx deposition was negligible in liver, although the oxalate concentration there must be highest.
Genetic phenotypes and clinical characteristics description of hereditary transthyretin patients in China
Authors: He XinYue , Tian Zhuang , Guan HongZhi , Zhang ShuYang 
Published: April 2022

Abstract
This study described 126 Chinese patients of hereditary transthyretin amyloidosis identified through a review of 29 literatures published between 2007 and 2020. The most common genotype in the Chinese population was Gly83Arg (25, 19.8%), which most likely presented visual and neurological abnormalities without reported death. The second and third common genotype were Val30Met (22,17.4%) and Val30Ala (10,7.9%). Peripheral Neurological manifestations (91,72%) were dominant in 126 patients. The following manifestation was autonomic neurological abnormalities (73,58%). Half of the cases were reported with visual disorders and nearly one-third of the cases presented cardiac abnormalities. Among all 126 reported patients, 48.4% were classified as neurological type, 50.0% as mixed type and only 1.6% as cardiac one. In addition. Chinese patients were mostly early onset (age of onset was 41.8years), the time from onset to death was 9.4 years. Subjects with cardiac involvement had a shorter survival duration.
Relationship Between Mental Health and Health Work Functioning During the Covid-19 Pandemic in Uganda
Authors: Akello Harriet , Kennelly Brendan , Cullinan John 
Published: April 2022

Abstract
Methods
A cross-sectional study was conducted in the various health facilities and institutions at national and sub-national levels in Uganda. The participants were health care workers and first responders working in the health sector during the COVID-19 pandemic in Uganda. The mental health status of the health workforce was measured using the Depression, Anxiety and Stress Scale 21 instrument. The Nurses Work Functioning Questionnaire was used to measure health work functioning. The data for the study was collected using the Survey Monkey tool and exported and cleaned in Microsoft Excel 2019. The data were analyzed using the Statistical Package of STATA® version 16. Descriptive statistics, such as mean values, percentages, frequencies, and charts, were used to summarize the findings. Multinomial logistics regression was used to estimate an ologit model of the relationship between mental health and health work functioning. The results were measured using odds ratio.
Results
A total of 533 responses were obtained between June and July 2021, from 90 districts in Uganda. Three of the respondents did not consent to the study. 29.26% of responses were excluded during the analysis of the results because of missing data. 374(70.17%) responses from 82 districts in Uganda was used for the analysis. The prevalence of depression was 40.37%, stress was 25.7% and, anxiety was 47.06% among health care workers during the response to the COVID-19 pandemic in Uganda. The factor of mental health associated with work function impairment were avoidance behavior and lack of energy and motivation.
Conclusion
The prevalence of depression, anxiety and stress was high in Uganda during the peak of the response. Avoidance behavior is a determinant of mental health associated with health work function impairment. The government of Uganda needs to develop interventions that will strengthen the mental health and psychosocial well-being of health workers when providing health care services.
Stromal Cell Adhesion Predicts Severity of Metastatic Disease
Authors: Birmingham Katherine , Yeoman Benjamin , Beri Pranjali , Tuler Jeremy , Williams Isabelle , Kumar Aditya , Klein Sarah , Katira Parag , Engler Adam 
Published: April 2022

Abstract
Despite better outcomes with early-stage detection, local invasion significantly reduces patient survival rates for many carcinomas. Heterogeneity within and between tumors has precluded identification of predictive biological markers, but adhesion strength has emerged as a potential biophysical marker. Here we demonstrate that cells disseminating from mammary tumors are weakly adherent, and when presorted by adhesion, primary tumors created from strongly adherent cells exhibit fewer lung metastases than weakly adherent cells or unsorted populations. Migratory ontologies from tumors correlate with freshly sorted cells, suggesting that cell intrinsic differences are maintained in vivo. We further demonstrate that admixed cancer lines can be separated by label-free adhesive signatures using a next-generation flow chamber. When applied to metastatic tumors, the device retrospectively predicted metastatic disease from stromal samples with 100% specificity, 85% sensitivity, and AUC of 0.94. Data from this device suggest that label-free adhesive signatures may effectively predict clinical outcomes in patients.
Second and third harmonic generation from simultaneous high peak- and high average-power thin disk laser
Authors: Andral Ugo , Walch Pierre , Moreno Victor , Mahieu Benoit , Produit Thomas , Lozano Magali , Bizet Laurent , Herkommer Clemens , Moret Michel , André Yves-Bernard , Krötz P. , Metzger Thomas , Michel Knut , Mysyrowicz André , Kasparian Jérôme , Lupinski Dominique , Houard Aurelien , Wolf Jean-Pierre 
Published: April 2022

Abstract
We report Second Harmonic Generation (SHG) and Third Harmonic Generation (THG) energy conversion efficiencies up to 59% and 27%, respectively for laser pulses simultaneously delivering high peak power in the sub-TW range and average powers in the sub-kW range. No damage or efficiency decrease is observed after more than 100 hours operation time. The resulting high-energy visible and near-UV pulses are suitable for applications like lightning control, material analysis and machining, or OPCPA pumping.