bluuebunny/crossref_metadata_2025_split huggingface dataset:
NON-INVASIVE CENTRAL BLOOD PRESSURE ESTIMATIONS IN PATIENTS WITH OR WITHOUT CHRONIC KIDNEY DISEASE: A PILOT PROJET
Authors: Côté Nadège , Abbaoui Yasmine , Spanneut Théo , Agharazii Mohsen , Goupil Rémi 
Published: June 2022

Objective:
Central systolic blood pressure (SBP) is a better surrogate for hemodynamic strain on the myocardium, brain and kidneys. In the context of chronic kidney disease (CKD), where the blood flow to the kidneys is reduced and there is a higher degree of aortic stiffness, estimation of central BP through non-invasive methods needs to be validated. The aim of our study is to determine the accuracy of brachial and central SBP, as measured and estimated by two devices, towards the invasively measured aortic BP, in CKD patients compared to patients without CKD.

Design and method:
This is a multicenter pilot study taking place at the hospitals Hotel-Dieu de Québec and Sacré-Coeur de Montréal. Patients undergoing non-urgent coronary angiograms are undergoing evaluation of non-invasive and invasive BPs simultaneously in supine position. In brief, intraarterial aortic BPs are recorded in the aorta within 3 cm of the aortic valve for every heartbeat for 30 seconds then averaged. Non-invasive central and brachial BP measures are recorded concurrently to the intraarterial aortic BP recordings with WatchBP central and Mobil-o-graph. All measurements are recorded on the contralateral arm used for angiography.

Results:
In 34 subjects (29% female, mean age 64.2 ± 8.7). In the CKD group (n = 8, eGFR < 30 ml/min/1.73m2) and the control group (n = 26, eGFR> 30 ml/min/1.73m2). Brachial cuff-SBP underestimated aortic SBP in CKD (-10.0 ± 19.6 mmHg) but overestimated aortic SBP (3.9 ± 16.3 mm Hg) in the control group. Mobil-o-graph estimations are more precise than the brachial BP in CKD (0.0 ± 10.1 mmHg) but not in the control group (6.5 ± 14.7 mmHg). WatchBP Central SBP estimations are also more precise than the brachial BP in CKD (1.2 ± 10.8) but overestimated aortic SBP in the control group (13.4 ± 18.9).

Conclusions:
The preliminary results indicate that brachial SBP underestimates aortic SBP by in CKD as compared to controls, and that estimation of central BP by both devices provide a better estimate of aortic SBP in CKD than in controls. These preliminary results suggest that the use of central BP estimations could be beneficial for the management of hypertension in CKD.
WHITE COAT EFFECT LEVEL CORRELATED WITH THE ECHOCARDIOGRAPHIC PARAMETERS AND COMPOSITE ENDPOINT DATA IN TREATED PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Andreeva Galiya , Koshelyaevskaya Yana , Smirnova Marina , Gorbunov Vladimir , Kurekhyan Armine 
Published: June 2022

Objective:
The aim of our study was to determine relationship between echocardiography (Echo) left ventricular mass index (LVMI), composite endpoint data and white coat effect (WCE) level in treated patients with arterial hypertension (AH).

Design and method:
We nalysed database (treated AH patients (n = 125) with concomitant chronic diseases without exacerbation or in compensation stage). This study was prospective and included three visits every 3 months: 1 visit - screening, ambulatory blood pressure monitoring (ABPM) session, Echo; 2 - assessment of the patient’s status and the therapy effectiveness; 3- assessment of the patient’s status, ABPM session, Echo (the total number of ABPM was 239, Echo - 240). We assessed composite endpoint after 30.1 ± 7.6 months from the screening visit (the primary composite endpoint included death for any reason angina pectoris, transient ischemic attack, development of chronic heart failure, arterial revascularization, frequent ventricular extrasystoles, atrial fibrillation, secondary - deterioration of the cardiovascular diseases course and tertiary endpoint - deterioration of the arterial hypertension, concomitant diseases course). We used ANOVA for statistical analysis.

Results:
The baseline mean (M ± m) daytime systolic BP (SBP) was 125.1 ± 9.8 and diastolic (DBP) - 76.1 ± 7.0 mm Hg, age was 62.8 ± 9.0 years. We identified a positive correlation between tertiary composite endpoint data and WCE: for systolic WCE (SWCE) (F = 4.7, p < 0.031). We found correlations between WCE and Echo parameters: 1) SWCE level had with LVMI (r = 0.16, p < 0.017); 2) diastolic WCE (DWCE) had negative relationship with end-diastolic (EDD) and systolic (ESD) diameters (r = -0.181, p < 0.007 and r = -0.187, p < 0.005); with ejection fraction (EF) and posterior wall thicknesses (PWT) (r = -0.176, p < 0.008 and r = -0.142, p < 0.033). In addition, we have identified that age and duration of AH were associated with SWCE, height and body mass index (BMI) had negative correlations with DWCE (see table). Thus, SWCE level had positive correlation with tertiary composite endpoint results (F = 4.7, p < 0.031) and LVMI (r = 0.16, p < 0.017). DWCE level had negative relationships with Echo LV contractility indices (ESD, EDD, EF).

Conclusions:
Thus, only systolic WCE level had correlation with composite endpoint data and LVMI. DWCE level had negative associations with echocardiography LV contractility parameters.
BLOOD PRESSURE VARIABILITY ASSESSED WITH OFFICE, HOME AND AMBULATORY MEASUREMENTS BEFORE AND AFTER ANTIHYPERTENSIVE DRUG TREATMENT: THE REVERENT TRIAL
Authors: Kyriakoulis Konstantinos , Kollias Anastasios , Bilo Grzegorz , Soranna Davide , Liu Chang-Yuan , Pengo Martino , Zambon Antonella , Zhang Wei , Wang Jiguang , Stergiou George , Parati Gianfranco 
Published: June 2022

Objective:
Blood pressure (BP) variability (BPV) can be assessed using office (OBP), home (HBP) and ambulatory BP (ABP) measurements. In this analysis BPV indices derived using all the three methods were compared before and after 10 weeks of antihypertensive drug treatment.

Design and method:
Untreated hypertensives (or treated after washout period) with elevated BPV (systolic HBP standard deviation [SD] > 7 mmHg and/or systolic daytime ABP SD > 12 mmHg), were nalysedd to ramipril 10 mg or nifedipine gastrointestinal therapeutic system (GITS) 30 mg once daily, in the context of a multicenter 10-week, prospective, nalysedd, open-label, blinded-end point study. BPV was assessed using SD and coefficient of variation (CV) [weighted SD (wSD) and weighted CV (wCV) for 24h-ABP variability) of individual measurements.

Results:
Data from 146 participants from three research centers (Athens, Milan, Shanghai) were nalysed (mean age 53 ± 10 [SD] years, males 60%, baseline systolic OBP, HBP and 24h-ABP 143 ± 10, 138 ± 10, and 143 ± 10 mmHg, respectively). Systolic CV assessed by HBP was decreased with treatment, by OBP was unchanged and by ABP increased (p < 0.05). HBP and ABP (not OBP) variability indices presented weak to moderate correlation, which was consistent before and after treatment (Table). HBP and ABP (not OBP) variability indices presented slight to fair agreement in detecting participants with high systolic BPV (top quartile of respective distribution) both before and after treatment (kappa statistic range 0.12–0.27).

Conclusions:
These data showed a moderate association between out-of-office (but not office) BPV indices both before and after administering BP lowering treatment, with reasonable agreement in detecting individuals with high BPV. Out-of-office BP measurements provide more similar BPV information than office measurements, both before and after administering antihypertensive drug treatment.
PATTERNS OF SHORT-TERM BLOOD PRESSURE VARIABILITY BY AGE IN SERIES OF EXAMS CARRIED DURING TWENTY-FIVE YEARS
Authors: Sousa Andréa Cristina , Magalhães Fabrício Galdino , Silva Suelen Benta , Simeoni Adélia Rocha , Inuzuka Sayuri , Batista Sandro Rogério , Vale Raquel Mendonça , Amaral Monica Santos , Souza Weimar Kunz Barroso , Sousa Ana Luiza Lima 
Published: June 2022

Objective:
To describe patterns of short-term blood pressure variability and the association with age.

Design and method:
Cross-sectional study, with series of exams executed during 25 years. Variables used: gender, age, blood pressure values in different periods, nocturnal drop, coefficient of variation (CV) and standard deviation; normal nocturnal drop between 10% and 20% of blood pressure reduction, media of 24 hours CV-PAS was used for cutoff point. Effect sizes were calculated for differences in means – of Cohen, performed ANCOVA in all ABPM periods using the covariate sex; significance level for all nalyses 5%.

Results:
Analyzed 2073 exams, 66.3% of the female sex; medium age 58.3 years (±12.6), 29.4% were older than 65 years. The elderly, in all periods, had higher SBP media and lower of DBP. The elderly showed less BP control during nighttime (27.3%) than adults (35.3%) and more absence of nighttime drop (83.5%). Nocturnal drop in elderly was 17.7%/systolic and 36.6%/diastolic; in adults was 26.8%/52.1%, respectively. The Systolic Coefficient of Variation was higher among elderly in the 24hr period 10.8 (±3.1) x 10.0 (±2.4), daytime 10.3 (±2.9) x 9.0 (±2.4) and nighttime 9.0 (±3.0) x 8.6 (±2.8).

Conclusions:
The elderly had less pressure control during sleep and more absence of nocturnal drop; furthermore, they had a higher Systolic Coefficient of Variation in all periods.
BEHAVIOR OF PRESSURE VARIABILITY IN PATIENTS WITH ARTERIAL HYPERTENSION AND DIABETES MELLITUS WITH OR WITHOUT INSULIN USE AND THE INFLUENCE OF THE NUTRITIONAL STATE IN BRAZIL
Authors: Silva Suelen , Sousa Andrea Cristina , Sousa Ana Luíza , Vitorino Priscila , Lima Lucas , Magalhães Fabrício , Souza Weimar 
Published: June 2022

Objective:
To evaluate the behavior of systolic and diastolic blood pressure variability through residential measurements in patients with hypertension and diabetes mellitus with or without insulin use associated with nutritional status.

Design and method:
Cross-sectional study, which evaluated patients undergoing prognosis and/or monitoring of arterial hypertension, who underwent blood pressure examination outside the clinic through telemonitoring by the TeleMRPA platform, between 2015 and 2020, divided into two groups: diabetic hypertensive patients with and without using insulin. Incomplete information and age under 18 and over 100 were excluded. Variables evaluated: body mass index, age, systolic and diastolic blood pressure variability obtained by home blood pressure monitoring, calculated by standard deviation. The results were presented using mean, standard deviation and inferential statistics through the unpaired t-student test, considering a confidence interval of 95% and a significance level of 5%.

Results:
57,379 patients with arterial hypertension were selected, of which 2,189 had diabetes mellitus, meeting the criteria, with a mean age of 64.1 (~ 13.02) years for patients with use, and 64.7 (~ 12.26) years for did not use insulin. The body mass index for patients who used insulin was 28.6 (~ 4.57) kg/m2 and for those who did not use it was 29.1 (~ 4.65) kg/m2, without statistical significance (p 0.171). The values of systolic blood pressure variability for patients with and without insulin use were, respectively, 11.1 (~ 4.44) and 10.0 (~ 3.93) with p = 0.0002, and for the variability of diastolic blood pressure, 6.5 (~ 2.94) and 5.9 (~ 2.67) with p = 0.017.

Conclusions:
In diabetic hypertensive patients, nutritional status was not associated with insulin use. In relation to systolic and diastolic blood pressure variability, there were higher elevations in the group that used insulin. Home blood pressure monitoring is an important alternative for monitoring blood pressure variability, which is a predictor of cardiovascular events in hypertensive and diabetic patients, and can be used reliably through telemonitoring.
POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME: DIVERSE ETIOLOGIES
Authors: Khadhar Meriam , Barbouch Samia , Hidri Hafedh , Ounissi Mondher , Bêcha Monti , Abderrahim Ezzeddine 
Published: June 2022

Objective:
Posterior Reversible Encephalopathy, called PRES, is a clinico-radiological entity individualized for the first time in 1996 as a special form of hypertensive encephalopathy.

Design and method:
We collected retrospectively 8 cases of PRES Syndrome either on-specific or followed in Internal Medicine service. All patients had a confirmed diagnosis by brain MRI.

Results:
There were 5 women and 3 men, mean age was 30 years (range 16–66 years). Three patients had a past history of arterial hypertension. Two patients had moderate chronic renal failure, three had a chronic renal failure on hemodialysis, one had normal renal function and the two others were transplanted. Hypertension with diastolic blood pressure greater than 120 mmHg was noted in two patients. For the others, it was an acute and sudden increase of blood pressure usually well balanced. Neurological manifestations are on-specific, such as confusion, a prolonged critical post coma or seizure initially focal (Braved-Jacksonian) limited to brain lobe affected by the PRES which become generalized secondarily. All patients had seizures, one presented a status epilepticus. They all underwent magnetic resonance imaging (MRI). Typical imaging findings characteristically involve the white matter bilaterally in the parieto-occipital regions. Involvement of the white matter is constant. To equilibrate the systemic blood pressure, we used calcium channel blockers in all cases (nicardipine in the electric syringe pump in one case). The therapeutic goal was to maintain a mean arterial pressure between 105 and 125 mmHg.

Conclusions:
PRES is highly diverse in terms of etiologies. Our series is particular by the large number of cases of PRES compared to the literature but especially by the diversity of the etiologies of PRES. All our patients had chronic renal failure and / or underlying nephropathy.
SEASONAL VARIATION IN METEOROLOGICAL PARAMETERS AND BLOOD PRESSURE IN CROATIAN ADULT POPULATION
Authors: Jelakovic Ana , Srnec Lidija , Orlic Mirko , Premuzic Vedran , Domislovic Marija , Begic Zvonimir , Barisic Karla , Radunovic Danilo , Prelevic Vladimir , Dika Zivka , Stevanovic Ranko , Jelakovic Bojan 
Published: June 2022

Objective:
There are many reports on the seasonality of cardiovascular risk factors particularly of blood pressure (BP). Our aim was to analyze association of BP with various meteorological parameters in random sample of general Croatian adult population.

Design and method:
EHUH -2 study is nation-wide survey (Croatian Science Foundation) on prevalence, treatment and control of hypertension in Croatia. In 2018–2021 a random sample of 1321 subjects were enrolled. Office blood pressure (BP) and heart rate were measured in sitting position using Omron 3 device three times and average BP values were calculated. Estimated pulse wave velocity (ePWV) was calculated using validated equation. Meteorological data (mean daily 2 m air temperature – T2m, atmosphere pressure, air humidity measured at meteorological stations according to WMO standards) were collected in Croatian Meteorological and Hydrological Service.

Results:
We found significant difference in systolic and diastolic BP, heart rate and ePWV accorss nalys (Figure 1a and Figure 2), as well significant correlation between all parameters and T2m. (Figure 3 for systolic BP). There is nonsignificant trend in association between systolic BP and air humidity. We failed to find association of diastolic BP, heart rate and ePWV with any of nalysed meteorological parameters. Furthermore, we found inverse association between systolic BP, diastolic BP and heart rate with T2m i.e. we confirmed seasonal fluctuations (Figure 1b).

Conclusions:
Our data confirmed findings of seasonal (inverse) variation between BP and T2m. Interestingly, we found association of seasonal variation and ePWV. T2m has impact on long-term BP variability but also on ePWV and should be taken into account in clinical research as well as in regular clinical work.
OBESITY AND MYELOPROLIFERATIVE NEOPLASMS: A SYSTEMATIC REVIEW
Authors: Gaman Mihnea-Alexandr , Epingeac Mirela Elena , Gaman Amelia Maria , Diaconu Camelia Cristina 
Published: June 2022

Objective:
Obesity is a known trigger for carcinogenesis and its involvement is proven in the development of solid and blood cancers. However, the involvement of obesity in myeloproliferative neoplasms (MPNs), namely polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), has not been assessed so far.

Design and method:
Systematic review in PubMed/MEDLINE from its inception to March 13th, 2022. The database was searched using specific keywords/word combinations to identify relevant papers which were further evaluated if they were original articles and investigated the role of obesity in MPNs. Reviews, case reports, meeting abstracts, letters to the editor, in vivo/in vitro studies were excluded.

Results:
The initial search yielded 88 results of which 62 remained after the exclusion of reviews/case reports (n = 26). After screening of titles/abstracts, 25 full-texts were assessed of which 18 were entered into the qualitative analysis. Most conclusions were drawn from singular studies. Two papers pointed out that obesity affects the evaluation of red cell mass in PV due to the hypovascular nature of the adipose tissue, arguing for new reference ranges in obese subjects. Adults with obesity during adolescence had an increased risk of MPNs development during adulthood. Obesity was particularly linked to the development of ET. Obese MPNs adults had an elevated number of bone marrow adipocytes, higher total symptom burden (U-shaped association with BMI), higher rate of cerebrovascular accidents (ET) and venous thrombosis, lower risk of post-PV myelofibrosis and stroke, higher survival rates. Obesity did not influence anxiety in MPNs or the occurrence of thrombosis (ET). However, lower survival rates and thrombosis-free survival were noted in MPNs patients with multiple cardiovascular risk factors. PMF patients treated with ruxolitinib who had higher BMI values registered better outcomes. Ruxolitinib-treated subjects exhibited an increase in BMI. Obesity did not influence the outcome of allogeneic bone marrow transplantation in PMF, nor did it influence the outcome of this procedure in elderly patients transplanted for myeloid malignancies.

Conclusions:
Obesity can influence the development and evolution of MPNs and should be carefully monitored. Further studies should assess the obesity paradox in MPNs.
STUDY ON HYPERTENSION-RELATED TARGET ORGAN DAMAGE IN ESSENTIAL HYPERTENSION PATIENTS WITH HYPOKALEMIA
Authors: Wang Qiongying , Zhang Haodong , Wang Wenjuan , Pei Ying , Kou Chengkun , Yu Jing 
Published: June 2022

Objective:
To explore the early target organ damage in essential hypertension patients with hypokalemia,we nalysed ambulatory blood pressure, cardiac structure and function, early renal function, neck blood vessels and head imaging in patients with essential hypertension.

Design and method:
590 patients with hypertension who were nalysedsed from January 2015 to June 2021 were selected, including 257 cases with hypokalemia and 76 cases have primary aldosteronism.Collect patients’ general information, biochemistry, urine routine, office blood pressure, 24 h ambulatory blood pressure monitoring.The results were statistically nalysed by SPSS.

Results:
Compared with the essential hypertension group,average systolic blood pressure during the day, average diastolic blood pressure during the day, average systolic blood pressure at night, and average diastolic blood pressure at night, 24 h average systolic blood pressure, 24 h average diastolic blood pressure, daytime systolic blood pressure load rate, night diastolic blood pressure load rate, 24 h systolic blood pressure load rate, and 24 h diastolic blood pressure load rate were significantly higher in both the hypokalemia group and the essential hyperaldosteronism group (P < 0.05). Urinary microalbumin in the primary hypertension with hypokalemia group and primary aldosteronism group was significantly higher than that in the primary hypertension group (P < 0.05).The 24 h average diastolic blood pressure, night systolic blood pressure load rate, and 24 h systolic blood pressure load rate were all positively correlated with urine microalbumin(P < 0.05); they were negatively correlated with serum potassium ion (P < 0.05). The nighttime mean systolic blood pressure and nighttime systolic pressure load rate were independently positively correlated with urine microalbumin (P < 0.05), and serum potassium ions were independently negatively correlated with urine microalbumin by Multiple linear regression analysis (P < 0.05).

Conclusions:
Essential hypertension patients with hypokalemia have higher 24 h blood pressure and blood pressure load rate, and have more serious early renal damage than patients with normal potassiumic Otherwise, Serum potassium concentration was an independent risk factor for urinary microalbumin in essential hypertension patients with hypokalemia
THE PROGNOSTIC VALUE OF FATTY LIVER INDEX FOR CARDIOVASCULAR EVENTS IN HYPERTENSIVE PATIENTS
Authors: Siafi Eirini , Andrikou Ioannis , Thomopoulos Costas , Konstantinidis Dimitrios , Manta Eleni , Polyzos Dimitrios , Tatakis Fotis , Zammanis Ioannis , Drogkaris Sotirios , Kariori Maria , Kakouri Niki , Liatakis Ioannis , Filippou Christina , Tsioufis Konstantinos 
Published: June 2022

Objective:
The prevalence of on-alcoholic fatty liver disease (NAFLD) has been increasing rapidly worldwide affecting 25–30% of population. Fatty liver index (FLI) is a validated marker of NAFLD and can be used as a screening tool for hepatic steatosis. The purpose of the study was to evaluate the relationship between FLI and the risk of major cardiovascular events in hypertensive patients.

Design and method:
903 hypertensive patients without history of cardiovascular disease participated in the study (mean age 52.7 ± 11.4 years; males 55%; baseline clinic BP 149.8 ± 15.2/95.5 ± 10.1 mmHg). Participants were prospectively evaluated for a mean follow-up period of 6.0 ± 3.3 years with at least one annual visit. The diagnosis of NAFLD was based on FLI and consequently patients were divided in two groups according to the presence of NAFLD. The primary endpoint was a composite of major cardiovascular events.

Results:
The incidence of cardiovascular events during the follow up was 8.5% (n = 77). Patients without NAFLD (n = 625) had better BP control compared to their counterparts with NAFLD (n = 278) during follow up (43% vs 33%, p = 0.02). A Cox-regression analysis indicated that age (HR 1.09 CI 1.04–1.13, p < 0.01), smoking (HR 2.4 CI 1.1–5.2, p = 0.03) and FLI (HR 2.7 CI 1.9–4.1, p < 0.001) were significant independent determinants of the outcome. The presence of NAFLD at baseline visit was also a significant independent determinant of the outcome (HR 5.2 CI 2.4–11.1, p < 0.001).

Conclusions:
FLI has an independent prognostic value for the incidence of cardiovascular events in hypertensive patients. Therefore, it could be useful in identifying patients at higher risk of cardiovascular events. Further studies will clarify whether the early treatment of NAFLD could reduce the incidence of cardiovascular disease.