bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asymmetric Transfer Hydrogenation of Diaryl Ketones with Ethanol Catalyzed by Chiral NCP Pincer Iridium Complexes
Authors: Qian Lu , Tang Xixia , Wang Yulei , Liu Guixia , Huang Zheng 
Published: January 2022

Comprehensive SummaryThe use of a chiral (NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent. This reaction was applicable to various ortho‐substituted diaryl keontes, affording benzhydrols in good yields and enantioselectivities. This protocol could be carried out in a gram scale under mild reaction conditions. The utility of the catalytic system was highlighted by the synthesis of the key precursor of (S)‐neobenodine.
A phase 3 safety study of fosnetupitant as an antiemetic in patients receiving anthracycline and cyclophosphamide: CONSOLE‐BC
Authors: Matsuura Kazuo , Tsurutani Junji , Inoue Kenichi , Tanabe Yuko , Taira Tetsuhiko , Kubota Kaoru , Tamura Tomohide , Saeki Toshiaki 
Published: January 2022

BACKGROUNDFosnetupitant (FosNTP), an intravenous neurokinin 1 receptor antagonist, demonstrated a favorable safety profile with a potentially low risk of injection site reactions (ISRs) and promising antiemetic efficacy in patients receiving cisplatin‐based highly emetogenic chemotherapy in a previous phase 2 study. We conducted a randomized, double‐blind safety study to evaluate the safety profile of FosNTP, including ISRs, in patients receiving doxorubicin‐cyclophosphamide or epirubicin‐cyclophosphamide (AC/EC) chemotherapy.METHODSPatients scheduled to receive AC/EC were randomized 1:1 to receive 235 mg of FosNTP or 150 mg of fosaprepitant (FosAPR), both in combination with 0.75 mg of intravenous palonosetron and 9.9 mg of dexamethasone on day 1. The stratification factors were age category (<55 vs ≥55 years) and study site. The primary end point was the incidence of treatment‐related adverse events (TRAEs) with FosNTP.RESULTSOverall, 102 patients were randomized to FosNTP (n = 52) or FosAPR (n = 50), and all were treated with the study drug and evaluated for safety. The primary end point, the incidence of TRAEs, was similar with FosNTP (21.2%; 95% confidence interval [CI], 11.1%‐34.7%) and FosAPR (22.0%; 95% CI, 11.5%‐36.0%), with any‐cause ISRs observed in 5.8% and 26.0% of patients, respectively, and treatment‐related ISRs observed in 0% and 10.0%, respectively. The overall (0‐120 hour) complete response (defined as no emetic event and no rescue medication) rate, standardized by age category in the full analysis set, was 45.9% (23 of 51 patients) with FosNTP and 51.3% (25 of 49 patients) with FosAPR.CONCLUSIONSFosNTP demonstrated a favorable safety profile with a very low risk of ISRs in the AC/EC setting.
Detection of Short DNA Sequences with DNA Nanopores**
Authors: Yang Luyan , Cullin Christophe , Elezgaray Juan 
Published: January 2022

AbstractSeveral studies suggest strong correlation between different types of cancer and the relative concentration of short circulating RNA sequences (miRNA). Because of short length and low concentration, miRNA detection is not easy. Standard methods such as RT‐PCR require both the standard PCR amplification step and a preliminary additional step of reverse transcription. In this paper, we investigate the use of DNA nanopores as a tool to detect short oligonucleotide sequences at the single molecule level. These nanostructures show two different conformations depending on the presence of DNA analogues of miRNA sequences. By monitoring current across a lipid bilayer, we show that this change of conformation translates to different levels of conductance.
Actions in the spotlight: Differential effects of corporate social responsibility actions on organizational celebrity
Authors: Turner Kyle D. 
Published: January 2022

AbstractWhile the financial value of corporate social responsibility (CSR) has been thoroughly addressed in extant research, scholars have yet to fully explore the mechanisms through which CSR benefits the firm. Social approval assets, such as reputation or legitimacy, represent one mechanism through which CSR actions generate idiosyncratic value among stakeholders that is likely to lead to superior firm performance. The present study introduces a new social approval asset, organizational celebrity, to the CSR literature and proposes how CSR actions can be leveraged to generate high levels of attention and positive emotional resonance among stakeholders. In doing so, the model provides insight into how organizational celebrity is formed via distinctive CSR actions that generate media attention and emotional resonance among stakeholders. The conceptual model extends existing work integrating CSR as a key antecedent to the development of social approval assets as key intangible resources for the firm.
Optimization design of fractional‐order Chebyshev lowpass filters based on genetic algorithm
Authors: He Xue , Hu Zhizhong 
Published: January 2022

AbstractFractional‐order filters have received extensive attention from international scholars because of their greater design freedom and continuously stepped stopband attenuation rate. Based on genetic algorithm (GA), this paper proposes an optimum design approach for fractional‐order Chebyshev lowpass filters that meet design specifications. The fractional order and ripples attenuation of the normalized Chebyshev lowpass filter are calculated according to specifications, the integer order in the Chebyshev polynomial is replaced with the calculated fractional order, and then the fractional‐order Chebyshev polynomial is substituted into the magnitude response of the normalized Chebyshev lowpass filter along with the ripples attenuation to achieve the ideal response. The transfer function parameters of a fractional‐order filter are optimized using GA to make the magnitude response approximate the ideal response described above. This completes the optimized design of a fractional‐order Chebyshev filter that meets specifications. Given three different sets of design specifications, the fractional‐order Chebyshev filter designed using the proposed method is compared with one designed by another method in the literature. Finally, design examples are presented, stability analysis and Pspice simulations are performed, and an actual circuit is constructed to illustrate the effectiveness of the proposed method.
A low‐leakage single‐bitline 9T SRAM cell with read‐disturbance removal and high writability for low‐power biomedical applications
Authors: Abbasian Erfan , Gholipour Morteza 
Published: January 2022

AbstractThe design of power‐efficient SRAM cells is necessary for biomedical applications such as body area networks (BANs) to extent their battery life. SRAM cell's power consists of two main components, including leakage power and dynamic power, in which the former overcomes the latter in advanced technology. This paper presents a low‐leakage single‐bitline 9T (L2SB9T) SRAM cell. The proposed design is free from read‐disturbance issue and eliminates writing “1” problem. The results are carried out by utilizing HSPICE and 16‐nm CMOS PTM at a 0.7 V, 25°C, and under severe PVT variations. The proposed L2SB9T SRAM cell is comprehensively compared with other recently published SRAM cells including conventional 6T, write/read enhanced 8T (WRE8T), transmission‐gate 9T (TG9T), read‐disturb‐free 9T (RDF9T), fully differential 10T (Chang10T), data‐independent read port 10T (DIRP10T), and single‐bitline 11T (SB11T). It shows at least 1.26X/1.07X/1.01X improvement in read static noise margin (RSNM)/write static noise margin (WSNM)/write margin (WM). Furthermore, the leakage power is reduced by the proposed cell, at least 1.137X. Moreover, the suggested cell consumes the third/second best dynamic read/write power, which is 1.42X/1.37X lower than that of conventional 6T SRAM cell. The proposed L2SB9T SRAM cell performs its read/write operation reliably by showing at least 1.71X narrower speared in RSNM compared to the best SRAM cell and third best WM variability. For all these improvements, the proposed L2SB9T SRAM cell incurs a 4.20X/1.06X/1.808X penalty in read delay/write delay/layout area when compared with the best SRAM cells, that is, the Chang10T/6T/6T.
Facebook as Embodiment of Social Relations and Piety among American Muslim Women
Authors: Hahn Ashley 
Published: January 2022

AbstractBased on a three‐year‐long ethnographic research on a group of young Turkish‐American Muslim women, affiliated with a faith‐based social movement, I explored why these young women turned to Facebook to maintain their religious sisterhood after their graduation from high school and how their media choice and use of Facebook contribute to their Muslim subject formation. Drawing from literature on ethics and morality and employing a discourse‐centered approach to language and culture provide me with frameworks and tools that help to move beyond the homogenizing and prescriptive concepts like “media niche” and “networked ore digital religion” in this study. Through these frameworks, I demonstrated that their media choice and use is more about their ethical becoming as Muslim subjects rather than solely being about medium itself or performing religious identities. Besides, their moral project, that is becoming better Muslims, rely not only on religious codes and norms but also on everyday social norms and values. This study particularly demonstrates how new practices of mediation become part of existing and old ethical debates and therefore is important in shedding light on the media choices of individuals.
Censorship in the Study of Early Islam
Authors: Wood Philip 
Published: January 2022

AbstractThis article argues that an important driver for complaints about anti‐Muslim blasphemy has been the political and legal environment of Pakistan. It examines a case where an academic text on early Islam was suppressed because of fears over its reception in Pakistan. It argues that university presses ought to keep open a space where ideas can be critiqued in a non‐polemical fashion, but that, in this case, the globalized network in which university presses operate has served to stifle open discussion.
Assessing drivers of localized invasive spread to inform large‐scale management of a highly damaging insect pest
Authors: Nunez‐Mir Gabriela C. , Walter Jonathan A. , Grayson Kristine L. , Johnson Derek M. 
Published: January 2022

AbstractStudies of biological invasions at the macroscale or across multiple scales can provide important insights for management, particularly when localized information about invasion dynamics or environmental contexts is unavailable. In this study, we performed a macroscale analysis of the roles of invasion drivers on the local scale dynamics of a high‐profile pest,Lymantria dispar disparL., with the purpose of improving the prioritization of vulnerable areas for treatment. Specifically, we assessed the relative effects of various anthropogenic and environmental variables on the establishment rate of 8010 quadrats at a localized scale (5 × 5 km) across the entireL. dispartransition zone (the area encompassing the leading population edge, currently from Minnesota to North Carolina). We calculated the number of years from first detection ofL. disparin a quadrat to the year when probability of establishment ofL. disparwas greater than 99% (i.e., waiting time to establishment after first detection). To assess the effects of environmental and anthropogenic variables on each quadrat's waiting time to establishment, we performed linear mixed‐effects regression models for the full transition zone and three subregions within the zone. Seasonal temperatures were found to be the primary drivers of local establishment rates. Winter temperatures had the strongest effects, especially in the northern parts of the transition zone. Furthermore, the effects of some factors on waiting times to establishment varied across subregions. Our findings contribute to identifying especially vulnerable areas to furtherL. disparspread and informing region‐specific criteria by invasion managers for the prioritization of areas for treatment.
Functionalized Carbazolyl Hydro‐ and Allyl‐Silanes
Authors: Hädinger Pauline , Hinz Alexander 
Published: January 2022

AbstractThe synthesis and properties of silanes bearing a bulky carbazolyl substituent are described. Metathesis routes with different reagents under different conditions are required to obtain the compounds of the general formula RSi(X)2H and RSi(X)2All (X=Cl, N3, NCO, NCS, NH2, All=CH2CHCH2). The silanes were studied by XRD, NMR and IR spectroscopy and all findings were corroborated by DFT methods.
Novel prevention insights into depletion of oxidative stress status through regular exercise and grape seed effective substance in heart ischemia rat model
Authors: Zarei Safar , Taghian Farzaneh , Sharifi Gholamreza , Abedi Hassanali 
Published: January 2022

AbstractMyocardial ischemia (MI) is recognized as the most frequent cardiovascular disease which is the dominant cause of global morbidity and mortality. Artificial intelligence tools and integrative data analysis revealed superoxide dismutase, catalase, glutathione peroxidase, gap junction protein α, myosin heavy chains, and zinc finger transcription factor GATA4 are engaged in oxidative stress and in cardiomyopathy. Network analysis indicated that MAPK3 might be the highest distribution property and cut point in this network, which could be a potential candidate for preventing and treating oxidative stress in heart tissue. Among antioxidant agents, grape seed extract (GSE) is an effective substance that altered antioxidant status in heart tissue. Considering drug discovery methods, we illustrated that GSE might target the MAPK3 protein with sufficient binding affinity. Moreover, we found that low‐ and moderate‐intensity training might prevent the depletion of antioxidants after MI. GSE consumption altered the levels of superoxide dismutase, glutathione peroxidase, and catalase after 14 weeks. Therefore, the interaction of low‐ and moderate‐intensity training and GSE had a synergistic effect on the antioxidant status and relative expression of the Mapk3. Moreover, the interaction of high‐intensity training and GSE had a compensatory mechanism that could scavenge reactive oxygen species and improve endogenous antioxidants and modulate the Mapk3 level in MI rats. Consequently, we displayed positive influence and synergic effects of simultaneous GSE prescription and regular physical activity for 14 weeks to prevent acute and chronic heart ischemia cardioprotective phenomenon. Furthermore, the capacitation oxidative stress and relative expression of the Mapk3 was significantly increased by GSE and regular exercise.
Establishment and application of risk classification model for lead in vegetables based on spectral clustering algorithms
Authors: Jiang Tong‐qiang , Wang Zheng , Zhang Qing‐chuan , Wang Zu‐zheng , Cheng Bao‐lian 
Published: January 2022

AbstractThis study aims to evaluate the risk of lead pollution in 9 kinds of vegetables consumed by residents in 20 provinces/cities of China. Sampling data and vegetable consumption data from 20 provinces/cities in 2019 were used. Combined with dietary exposure assessment, the vegetable categories and provinces were paired, and a risk classification model based on spectral clustering algorithms was proposed. The results of the spectral clustering algorithm showed that the risk level of lead pollution in vegetables can be divided into five levels. The combination of vegetable‐province/cities at the risk level of 1 and 2 accounted for 92.78%, and that at the risk level of 4 and 5 accounted for 2.22%. The high‐risk combinations were fresh edible fungus–Shaanxi, fresh edible fungus–Sichuan, and fresh edible fungus–Shanghai and bean sprouts–Guangdong. In the proposed model, objective data were used as the classification index, and the spectral clustering algorithm was employed to select the optimal risk classification in a data‐driven way. As a result, the influence of subjective factors was effectively reduced, the risk of lead pollution in vegetables was classified, and the results were scientific and accurate. This study provides a scientific basis of supervision priorities for regulatory departments.
Venetoclax exposure‐efficacy and exposure‐safety relationships in patients with treatment‐naïve acute myeloid leukemia who are ineligible for intensive chemotherapy
Authors: Brackman Deanna , Eckert Doerthe , Menon Rajeev , Salem Ahmed Hamed , Potluri Jalaja , Smith B. Douglas , Wei Andrew H. , Hayslip John , Miles Dale , Mensing Sven , Gopalakrishnan Sathej , Zha Jiuhong 
Published: January 2022

AbstractThis study evaluated venetoclax population pharmacokinetics (popPK) in patients with treatment‐naïve acute myeloid leukemia and assessed the relationship between venetoclax exposure and clinical response for venetoclax in combination with either a hypomethylating agent (HMA) or low‐dose cytarabine (LDAC). A total of 771 patients who received venetoclax from 5 Phase 1–3 studies were included in the popPK model. Exposure‐response analyses included data from 575 patients for venetoclax/placebo plus HMA and 279 patients for venetoclax/placebo plus LDAC. The popPK model successfully characterized venetoclax plasma concentrations over time and confirmed venetoclax exposure did not vary significantly with age, weight, sex, mild to moderate hepatic impairment, or mild to severe renal impairment. Asian patients had 67% higher mean relative bioavailability than non‐Asian patients, however the range of exposures in Asian patients was similar to non‐Asian patients. For all efficacy endpoints with both treatment combinations, efficacy was higher in the venetoclax treatment groups compared with the respective control arm of placebo plus azacitidine or LDAC. Within patients who received venetoclax, no significant exposure‐efficacy relationships were identified for either treatment combination, indicating that the beneficial effects of venetoclax were already maximized in the dose ranges studied. There was no apparent effect of venetoclax exposure on treatment‐emergent Grade ≥3 thrombocytopenia or infections for either combination. Rates of treatment‐emergent Grade ≥3 neutropenia were higher in the venetoclax treatment arms compared with the respective control arms; however, within patients who received venetoclax, there was only a shallow relationship or no apparent relationship with venetoclax exposure for venetoclax plus HMA or LDAC, respectively. Along with the efficacy and safety data previously published, the exposure‐response analyses support the venetoclax dose regimens of 400 mg once daily (QD) plus HMA and 600 mg QD plus LDAC in treatment‐naïve AML patients who are ineligible for intensive chemotherapy.
Numerical solution of MHD, Soret, Dufour, and thermal radiation contributions on unsteady free convection motion of Casson liquid past a semi‐infinite vertical porous plate
Authors: Reddy K. Veera , Ramana Reddy G. Venkata , Sandhya A. , Krishna Y. Hari 
Published: January 2022

AbstractIn this paper, the unsteady motion of Casson liquid over a half‐infinite penetrable vertical plate with MHD, thermal radiation, Soret, and Dufour contributions have been explored numerically. In the physical geometry, the Casson liquid flows to the layer from the penetrable vertical plate. At the layer, Casson liquid is set into motion and the flow equations are illustrated using coupled partial differential equations (PDEs). This set of PDEs is simplified to form dimensionless PDEs with the use of normal nondimensional transformation. The controlling parameters' effects on the working fluid are extensively discussed on velocity, concentration, and temperature and presented graphically. Computational values of Nusselt plus Sherwood number and skin friction for controlling parameters are depicted in a tabular form. Our outcomes show that a raise in the Casson term depreciates the velocity because of the magnetic parameter influence on the fluid flow. The Soret parameter was found to accelerate the skin friction along with the Sherwood number coefficients. An incremental value of the Dufour parameter was detected to hike the skin friction alongside the Nusselt number. Results of this study were found to be in conformity with previously published work.
Empirical study on the impact of major asset restructuring on the price of sub‐new stocks in Chinese A‐shares
Authors: Mingli Zhang , Yijie Zhang , Simeng Qin , Juhong Gong 
Published: January 2022

AbstractWith the improvement of Chinese economic status, Chinese A‐share market has attracted more and more attention from international investors. Sub‐new stock is a general name for the companies which list less than a year, most companies of this category come from the China Growth Enterprise Market (GEM) and are high‐tech companies with high growth. To study the influence of major asset restructuring on the stock prices of different companies, this paper adopts the event study method to calculate the samples' abnormal return in a 20‐day window period, compares related party transactions and unrelated party transactions, as well as different payment methods for the restructuring. The analysis shows that the listed companies of Growth Enterprise Market can get higher excess returns, the sample of unrelated transaction obtains more abnormal income than the sample of related transaction. The research can provide a reference for local and international investors.
Does the Chinese labour force make sufficient efforts? Empirical evidence using non‐parametric analysis
Authors: Wang Qiao 
Published: January 2022

AbstractIn this study, we construct an incentive model under which the optimal wage incentive scheme is a linear contract. This linear incentive contract can induce truth telling by workers about their inefficiency types and promote optimal efforts by them. We use the non‐parametric kernel estimation method to estimate the model primitives to analyse the insufficient efforts in the Chinese labour market. The empirical results based on data collected from the China Health and Nutrition Survey show that efficient male workers in white‐collar occupations do not exert sufficient efforts in the Chinese labour market. And wages for male workers in white‐collar occupations are undervalued.
Estimating Infiltration in Open‐ended Furrow Irrigation by Modifying Final Infiltration Rate
Authors: Panahi Amir , Alizadeh‐Dizaj Amin , Ebrahimian Hamed , Seyedzadeh Amin 
Published: January 2022

AbstractThe Kostiakov–Lewis equation is one of the commonly used infiltration equations in furrow irrigation. Elliott and Walker developed a two‐point method to estimate coefficients of the Kostiakov–Lewis equation. The basic infiltration rate (fo) in the Kostiakov–Lewis equation is usually calculated by the inflow–outflow method to determine the other two Kostiakov–Lewis parameters. In that method the entire furrow is used as an infiltrometer, which can cause overestimation of fo. In this study, by considering a correction factor in the mathematical calculations where the newly calculated value of fo is represented as fo* and the values of the a and k parameters, as calculated during the advance phase, are represented as a* and k*. The amount of infiltration volume estimated by the proposed method was evaluated using 21 open‐ended furrow irrigation data sets by calculating the relative error (RE) index. The value of fo decreased and the values of a and k increased by using the proposed method as compared to the Elliott and Walker method. Therefore, the results showed that the proposed method estimated infiltration volume with greater accuracy (average absolute RE = 4.0%) as compared to the Elliott and Walker method (average absolute RE = 7.8%).