bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Pre-Exercise Carbohydrate Meal on the Effects of Yerba Mate Drink on Metabolism, Performance, and Antioxidant Status in Trained Male Cyclists
Authors: Krolikowski Thaiana C. , Borszcz Fernando K. , Panza Vilma P. , Bevilacqua Laura M. , Nichele Sarah , da Silva Edson L. , Amboni Renata D. M. C. , Guglielmo Luiz G. A. , Phillips Stuart M. , de Lucas Ricardo D. , Boaventura Brunna C. B. 
Published: July 2022

AbstractIntroductionThe consumption of yerba mate (YM), a source of antioxidants, in a fasted state increases fatty acid oxidation (FATox) during low–moderate-intensity exercise and improves performance in high-intensity exercise. However, the impact of a pre-exercise carbohydrate (CHO) meal on YM effects during exercise is unknown.ObjectiveWe investigated the effects of yerba mate drink (YMD) consumed in the fasted state (YMD-F) or after a CHO meal (YMD-CHO) on measurements of metabolism, performance, and blood oxidative stress markers in cycling exercise.MethodsIn a randomized, repeated-measures, crossover design, eight trained male cyclists ingested (i) YMD-CHO, (ii) YMD-F, or (iii) control-water and CHO meal (Control-CHO). The YMD (an infusion of 5 g of ultrarefined leaves in 250 mL of water) was taken for 7 days and 40 min before exercise. CHO meal (1 g/kg body mass) was consumed 60 min before exercise. The cycling protocol included a 40-min low-intensity (~ 53%V̇O2peak) constant load test (CLT); a 20-min time trial (TT); and 4 × 10-sall-outsprints. Blood samples and respiratory gases were collected before, during, and/or after tests.ResultsDuring CLT, YMD-CHO increased FATox ~ 13%vs. YMD-F (P = 0.041) and ~ 27%vs. Control-CHO (P < 0.001). During TT, YMD-CHO increased FATox ~ 160%vs. YMD-F (P < 0.001) and ~ 150%vs. Control-CHO (P < 0.001). Power output during TT improved ~ 3% (P = 0.022) in YMD-CHOvs. Control-CHO and was strongly correlated with changes in serum total antioxidant capacity (r = −0.87) and oxidative stress index (r = 0.76) at post-exercise in YMD-CHO. Performance in sprints was not affected by YMD.ConclusionCHO intake did not negate the effect of YMD on FAToxor TT performance. Instead, a synergism between the two dietary strategies may be present.Clinical Trial RegistrationNCT04642144. November 18, 2020. Retrospectively registered.
Study protocol: development and pilot testing of the Critical Care Pain Observation Tool for families (CPOT-Fam)
Authors: Shahid Anmol , Owen Victoria S. , Sept Bonnie G. , Longmore Shelly , Soo Andrea , Brundin-Mather Rebecca , Krewulak Karla D. , Moss Stephana J. , Plotnikoff Kara M. , Gélinas Céline , Fiest Kirsten M. , Stelfox Henry T. 
Published: July 2022

Abstract
Background
Patients in the intensive care unit (ICU) often have limited ability to communicate making it more difficult to identify and effectively treat their pain. Family caregivers or close friends of critically ill patients may be able to identify signs of pain before the clinical care team and could potentially assist in routine pain assessments. This study will adapt the Critical Care Pain Observation Tool (CPOT) for use by family members to create the CPOT-Fam and compare family CPOT-Fam assessments with nurse-provided CPOT assessments for a given patient.

Methods
This study will be executed in two phases:
1) Development of the CPOT-Fam — A working group of patient partners, ICU clinicians, and researchers will adapt the CPOT for use by family caregivers (creating the CPOT-Fam) and produce an accompanying educational module to deliver information on pain and how to use the tool. The CPOT-Fam will undergo preclinical testing with participants (i.e., members of the public and family caregivers of critically ill adults), who will complete the educational module and provide CPOT-Fam scores on sample cases. Feedback on the CPOT-Fam will be collected.
2) Pilot testing the CPOT — Fam family caregivers of critically ill adults will complete the educational module and provide information on the following: (1) demographics, (2) anxiety, (3) caregiving self-efficacy, and (4) satisfaction with care in the ICU. Family caregivers will then provide a proxy assessment of their critically ill loved one’s pain through the CPOT-Fam and also provide a subjective (i.e., questionnaire-based including open-ended responses) account of their loved one’s pain status. A comparison (i.e., agreement) will be made between family caregiver provided CPOT-Fam scores and ICU nurse-provided CPOT scores (collected from the provincial health information system), calculated independently and blinded to one another. Feasibility and acceptability of the CPOT-Fam will be determined.

Discussion
The results of this work will produce a family caregiver CPOT (i.e., CPOT-Fam), determine feasibility and acceptability of the CPOT-Fam, and compare pain assessments conducted by family caregivers and ICU nurses. The results will inform whether a larger study to determine a role for family caregivers in ICU pain assessment using the CPOT-Fam is warranted.
A case of afterload mismatch associated with shivering leading to fatal hypoxia in a COVID-19 patient
Authors: Suzuka Takanori , Naito Yusuke , Uemura Keiko , Ida Mitsuru , Egawa Junji , Kawaguchi Masahiko 
Published: July 2022

Abstract
Background
Fever and associated shivering are frequent symptoms in patients with coronavirus disease 2019 (COVID-19). High body temperature activates the immune system, which might be beneficial. However, shivering leads to high oxygen demand.

Case presentation
A 38-year-old man diagnosed with COVID-19 was transferred to our intensive care unit (ICU). His oxygen saturation (SpO2) level was approximately 92–95% and was managed with a high flow nasal cannula. Six hours after admission to the ICU, he started shivering, and his systolic blood pressure rose above 200 mmHg. Concomitantly, his SpO2 levels decreased rapidly. Mechanical ventilation was started, but oxygenation could not be maintained, requiring the establishment of extracorporeal membrane oxygenation (ECMO).

Conclusions
COVID-19 is known to cause thrombosis in the pulmonary microvasculature at the early stage of the disease. Under these circumstances, caution should be paid since shivering may worsen the patient’s condition.
Surgical face masks do not impair the decoding of facial expressions of negative affect more severely in older than in younger adults
Authors: Henke Lea , Guseva Maja , Wagemans Katja , Pischedda Doris , Haynes John-Dylan , Jahn Georg , Anders Silke 
Published: July 2022

AbstractSurgical face masks reduce the spread of airborne pathogens but also disturb the flow of information between individuals. The risk of getting seriously ill after infection with SARS-COV-2 during the present COVID-19 pandemic amplifies with age, suggesting that face masks should be worn especially during face-to-face contact with and between older people. However, the ability to accurately perceive and understand communication signals decreases with age, and it is currently unknown whether face masks impair facial communication more severely in older people. We compared the impact of surgical face masks on dynamic facial emotion recognition in younger (18–30 years) and older (65–85 years) adults (N = 96) in an online study. Participants watched short video clips of young women who facially expressed anger, fear, contempt or sadness. Faces of half of the women were covered by a digitally added surgical face mask. As expected, emotion recognition accuracy declined with age, and face masks reduced emotion recognition accuracy in both younger and older participants. Unexpectedly, the effect of face masks did not differ between age groups. Further analyses showed that masks also reduced the participants’ overall confidence in their emotion judgements, but not their performance awareness (the difference between their confidence ratings for correct and incorrect responses). Again, there were no mask-by-age interactions. Finally, data obtained with a newly developed questionnaire (attitudes towards face masks, atom) suggest that younger and older people do not differ in how much they feel impaired in their understanding of other people’s emotions by face masks or how useful they find face masks in confining the COVID-19 pandemic. In sum, these findings do not provide evidence that the impact of face masks on the decoding of facial signals is disproportionally larger in older people.
Statistical feature training improves fingerprint-matching accuracy in novices and professional fingerprint examiners
Authors: Growns Bethany , Towler Alice , Dunn James D. , Salerno Jessica M. , Schweitzer N. J. , Dror Itiel E. 
Published: July 2022

AbstractForensic science practitioners compare visual evidence samples (e.g. fingerprints) and decide if they originate from the same person or different people (i.e. fingerprint ‘matching’). These tasks are perceptually and cognitively complex—even practising professionals can make errors—and what limited research exists suggests that existing professional training is ineffective. This paper presents three experiments that demonstrate the benefit of perceptual training derived from mathematical theories that suggest statistically rare features have diagnostic utility in visual comparison tasks. Across three studies (N = 551), we demonstrate that a brief module training participants to focus on statistically rare fingerprint features improves fingerprint-matching performance in both novices and experienced fingerprint examiners. These results have applied importance for improving the professional performance of practising fingerprint examiners, and even other domains where this technique may also be helpful (e.g. radiology or banknote security).
Possible ameliorative effect of human placental extract on methotrexate-induced nephrotoxicity in albino rats
Authors: Mahran Hoda A. , Khedr Yasser I. , Gawaan Yasmeen M. , El-Gerbed Mohamed SA. 
Published: July 2022

Abstract
Background
Methotrexate (MTX) is one of chemotherapeutic drugs that induce several side effects. The present study aimed to investigate the ameliorative effect of human placental extract (HPE) against MTX-induced nephrotoxicity in rats. In this study, forty adult male albino rats were equally divided into four groups. Control group: rats were daily injected intraperitoneally with physiological saline (0.5 ml for each rat) for 5 days, HPE group: rats were subcutaneously injected with HPE at a dose level of 10.08 mg/Kg b.w/day for 2 weeks, MTX group: rats were intraperitoneally injected with MTX at a dose level of 5 mg/Kg b.w/day for 5 consecutive days, MTX and HPE group: rats were intraperitoneally injected with MTX (at the same dosage of MTX group) for 5 days and at the same time they were subcutaneously injected with HPE (at an exact dosage of HPE group), daily for 2 weeks. Twenty-four hours after the last dose for each treatment, rats were killed and blood samples were collected for determination of urea, creatinine, sodium (Na+) and potassium (K+) levels. Kidney tissues were taken for histological examination and immunohistochemical staining of both cysteine-aspartic protease-3 (caspase-3) and proliferating antigen Ki-67 (Ki-67) expressions.

Results
From the obtained data, MTX induced nephrotoxicity through a highly significant increase in urea, creatinine, Na+ and K+ levels compared with the control group. In addition to massive histological alterations, a highly significant increase in caspase-3 expression and a significant decrease in Ki-67 expression were observed. On the other hand, injection with HPE ameliorated urea, creatinine, Na+ and K+ levels comparing to MTX group. Moreover, HPE markedly improved the histological and immunohistochemical changes resulted from MTX treatment.

Conclusions
It is concluded that HPE ameliorated the nephrotoxicity induced by MTX.
Thymic plasmacytoma presenting as polyneuropathy and revealing multiple myeloma: a case report
Authors: Laroussi Syrine , Moalla Khadija Sonda , Kallel Faten , Makni Saadia , Kallel Nozha , Farhat Nouha , Damak Mariem , Elloumi Moez , Sellami Tahya , Ben Mahfoudh Khaireddine , Mhiri Chokri 
Published: July 2022

Abstract
Background
Multiple myeloma (MM) is the most frequent malignant plasma cell disorder with proliferation of neoplastic plasma cells in the bone marrow or other tissue, most commonly in the upper aerodigestive tract. The invasion of the thymus is exceptional. Neurological complications are usual, but represent exceptionally the revealing symptom.

Case presentation
We report a case of polyneuropathy revealing a thymic plasmacytoma as a mediastinal invasion of MM in a 48-year-old woman. She was admitted after developing progressive ascending distal paresthesias and weakness in lower limbs. Examination showed symmetrical distal sensorimotor impairment with axillary and inguinal adenopathies. Electroneuromyography revealed a sensorimotor length-dependent neuropathy. Serum protein electrophoresis showed monoclonal protein peak in β-γ globulin region. Immunoelectrophoresis showed IgA lambda monoclonal gammapathy. Myelogram and bone marrow biopsy revealed plasmocytosis of 5%. Chest computed tomography showed a histologically confirmed thymic plasmacytoma associated with a lytic lesion of the 5th rib leading to the diagnosis of MM.

Conclusions
The association between a thymic plasmacytoma and peripheral neuropathy is rare and a workup for MM is necessary to guide therapeutic management.
Could early infusion of fish-oil-based lipid emulsion affect the need for intensive care in moderately diseased COVID-19 patients? A randomized clinical trial
Authors: Soliman Omar M. , Abbas Yara H. , Aboelhassan Arafa Mohamed Ahmed , Ismail Eman Ahmed 
Published: July 2022

Abstract
Background
Sixty moderate diseased COVID-19 patients were divided into two equal groups and were enrolled in a randomized double-blind clinical trial. Group C was delivered standard enteral nutrition plus 100 ml/day of 0.9% normal saline. Group L was delivered fish-oil-based lipid emulsion (FOBLE) supplementation to standard enteral nutrition at a dose of 100 ml/day. Both groups infused at a rate of 12.5 ml/h over 8 h for 5 days. We aimed to compare the effect of FOBLE versus placebo in COVID-19 disease to clarify the impact on the number of patients shifted to the ICU, oxygenation, inflammatory markers, and short-term outcomes (7 days).

Results
The failed conventional care and shift to ICU was significantly lower in group L in comparison to group C (six patients (20.0%) versus 14 patients (46.7%) shifted to ICU, P-value = 0.028). The inflammatory markers were determined and evaluated. Throughout the trial, there were no significant changes with the exception of the 7th day neutrophil/lymphocyte ratio (NLR), when the ratio was lower in group L than in group C (6.10 (3.90–7.20) versus 9.65 (8.30–10.90), respectively, P-value 0.001).

Conclusions
In moderate diseased COVID-19 patients, early administration of parenteral FOBLE as an adjuvant to enteral feeding reduces shifts and so minimizes the burden on the ICU.

Trial registration
ClinicalTrials.gov PRS (NCT04957940). Registered on 5 July 2021.
Metrics to evaluate implementation scientists in the USA: what matters most?
Authors: Maddox Brenna B. , Phan Mary L. , Byeon Y. Vivian , Wolk Courtney Benjamin , Stewart Rebecca E. , Powell Byron J. , Okamura Kelsie H. , Pellecchia Melanie , Becker-Haimes Emily M. , Asch David A. , Beidas Rinad S. 
Published: July 2022

Abstract
Background
Implementation science has grown rapidly as a discipline over the past two decades. An examination of how publication patterns and other scholarly activities of implementation scientists are weighted in the tenure and promotion process is needed given the unique and applied focus of the field.

Methods
We surveyed implementation scientists (mostly from the USA) to understand their perspectives on the following matters: (1) factors weighted in tenure and promotion for implementation scientists, (2) how important these factors are for success as an implementation scientist, (3) how impact is defined for implementation scientists, (4) top journals in implementation science, and (5) how these journals are perceived with regard to their prestige. We calculated univariate descriptive statistics for all quantitative data, and we used Wilcoxon signed-rank tests to compare the participants’ ratings of various factors. We analyzed open-ended qualitative responses using content analysis.

Results
One hundred thirty-two implementation scientists completed the survey (response rate = 28.9%). Four factors were rated as more important for tenure and promotion decisions: number of publications, quality of publication outlets, success in obtaining external funding, and record of excellence in teaching. Six factors were rated as more important for overall success as an implementation scientist: presentations at professional meetings, involvement in professional service, impact of the implementation scientist’s scholarship on the local community and/or state, impact of the implementation scientist’s scholarship on the research community, the number and quality of the implementation scientist’s community partnerships, and the implementation scientist’s ability to disseminate their work to non-research audiences. Participants most frequently defined and described impact as changing practice and/or policy. This expert cohort identified Implementation Science as the top journal in the field.

Conclusions
Overall, there was a significant mismatch between the factors experts identified as being important to academic success (e.g., tenure and promotion) and the factors needed to be a successful implementation scientist. Findings have important implications for capacity building, although they are largely reflective of the promotion and tenure process in the USA.
Implementing community pharmacy-based influenza point-of-care test-and-treat under collaborative practice agreement
Authors: Hohmeier Kenneth C. , McKeirnan Kimberly , Akers Julie , Klepser Michael , Klepser Stephanie A. , Chen Christe , Klepser Donald G. 
Published: July 2022

Abstract
Background
Early and accessible testing for influenza with point-of-care testing (POCT) can be a critical factor for deciding to begin antiviral treatment. More than 10,000 pharmacies across the USA offer Clinical Laboratory Improvement Amendments-waived POCT for infectious diseases, such as influenza A/B. Knowledge of barriers and facilitators to large-scale POCT implementation may be useful in scaling POCT for influenza test-and-treat services (Flu POCT). The objective of this study was to explore the experiences of pharmacists who were early adopters of Flu POCT and treatment under collaborative practice agreement in community pharmacy settings.

Methods
Qualitative research design with in-depth, semi-structured virtual video interviews of licensed US community pharmacists. Interview questions were derived from the Consolidated Framework for Implementation Research (CFIR). Interviewees were selected via a purposeful sampling of pharmacists who were enrolled in a nationwide clinical trial involving pharmacy-based influenza test-and-treat under a collaborative agreement. Interviews were recorded and transcribed. A deductive analytic approach was used via constructs from the CFIR.

Results
Six pharmacists were interviewed. Interviews ranged from 28 to 70 min, with an average length of 46 min. Four broad themes emerged from the data, and each had corresponding subthemes and supporting quotes: influence of the Flu POCT service characteristics on pharmacy implementation, influence of factors outside of the pharmacy setting in Flu POCT implementation, factors within the pharmacy setting influencing implementation, and process of implementing Flu POCT. A novel pharmacy-based Flu POCT implementation framework is presented.

Conclusions
Implementation of community pharmacy-based Flu POCT services is feasible; but, a thorough understanding of both barriers and facilitators to their implementation is needed to increase the spread and scale of these programs. Specifically, pharmacy stakeholders should focus efforts on increasing patient and provider awareness, pharmacist acceptance, leadership support, and support of health providers external to the pharmacy to improve implementation success.
Diagnosis of portal vein thrombosis in cirrhotic patients with and without hepatocellular carcinoma
Authors: Serag Waleed M. , Eysa Basem E. 
Published: July 2022

Abstract
Background
The levels of Annexin A5 (Annexin V) were measured in patients with and without HCC who had liver cirrhosis. These patients were followed for 12 months to determine the incidence of PVT and to determine the role of Annexin V in the diagnosis of PVT. Our goal was to look at the value of Annexin A5, platelet count, spleen size, portal flow velocity, portal vein width, Fibrosis 4, and APRI score in these individuals to see if they might be used as PVT markers.

Methods
Between March 2017 and August 2018, ninety-one HCV patients with cirrhosis with and without HCC, as well as a control group of twenty healthy people, were included in this longitudinal study at the NHTMRI. The blood anxA5 level was determined using a commercial Hyphen BioMed immunoassay using Stat Fax 4700’s Microstrip Reader l.

Results
Cirrhotic patients with and without HCC who developed PVT had higher Annexin A5 scales (5.75 + 0.18), compared to cirrhotic patients who did not develop PVT (3.63 + 1.08 (P 0.001). PVT was 20% in all cirrhotic patients after a year, 15% in cirrhotic patients without HCC, and 25% in cirrhotic patients with HCC. Cirrhotic patients who had PVT throughout the follow-up period had greater AnxA5 serum levels than cirrhotic patients who did not develop PVT.

Conclusions
In all cirrhotic patients, AnxA5 level, platelet count, spleen size, portal flow velocity, portal vein diameter, and Fibrosis 4 score might be employed as markers for PVT development.