bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Studies on Local Barrier Field Variations Above Field-Adsorbed Helium and Neon with a Micro-Probe Hole Field Ion Microscope
Authors: Ohta Yasushi , Kobayashi Ataru 
Published: September 2022

Abstract
The local field ion emission properties of helium and neon around a step edge atom of W(112) were examined at liquid nitrogen temperature using a micro-probe hole field ion microscope combined with a pulse-counting analysis. We have analyzed the mapped field ion densities obtained for both imaging gas atoms at their respective best local image voltages based on the formula for tunneling barrier strength and have evaluated the dipole moment of polarized adatom as well as the local field enhancement factor at the adatom site. We found that the dipole moments of helium and neon adatoms showed the same value, although the best local image field acting on the helium adatom is much higher than that on the neon adatom. We also found the same magnitude of local field enhancement factors for both noble gas field adsorptions. These results imply that the key to the best local image condition is the tunneling barrier field variations above the adatom. The vital role of the imaging gas atoms is to form an optimum dipole moment to create an ideal electric field distribution for the best local image appearance at each atom site depending on the different chemical nature of adatom species.
Das Multidimensionale Düsseldorfer Trauminventar (MDTI)
Authors: Pietrowsky Reinhard , Schmitz Annett , Zink Nicolas , Gieselmann Annika 
Published: September 2022

Zusammenfassung. Vorgestellt wird die Entwicklung und testpsychologische Evaluation des Multidimensionalen Düsseldorfer Trauminventars (MDTI), eines Fragebogens zur Erfassung des Traumerlebens unabhängig vom Trauminhalt. Dazu wurde eine Vorläuferversion, das Düsseldorfer Trauminventar (DTI; 51 Items), einer Stichprobe aus N = 715 vorgelegt, welche über E-Mail-Verteiler an Universitäten, sozialen Netzwerke sowie Medizin- und Traumforen rekrutiert und zu einem digitalen Fragebogenformular weitergeleitet wurden. Die Stichprobe bestand aus n = 444 weiblichen (62 %) und n = 270 männlichen (38 %) Teilnehmenden. Ihr Alter lag zwischen 15 und 73 Jahren. Das mittlere Alter betrug M = 30.03 Jahre ( SD = 10.36). Die Items wurden einer Hauptkomponentenanalyse mit obliquer Rotation unterzogen, um anschließend die reliabelsten und validesten Items herauszufiltern. Die Faktorenanalyse ergab eine eindeutige 5-faktorielle Struktur des Fragebogens mit sehr guten Reliabilitäten der Subskalen. Die verbliebenen 27 Items bilden nun die 5 Skalen des als Multidimensionales Düsseldorfer Trauminventar (MDTI) bezeichneten Fragebogens: (1) Inkorporation von Tagesereignissen, (2) Angenehme Trauminhalte, (3) Traumerinnerung, (4) Aversive Trauminhalte und (5) Persönliche Bedeutsamkeit der Träume. Mit dem MDTI ist es möglich, das Traumerleben unabhängig vom Trauminhalt zu erfassen.
Role of Water Vapor Modulation From Multiple Pathways in the Occurrence of a Record‐Breaking Heavy Rainfall Event in China in 2021
Authors: Gao Zhiqiu , Zhang Jianbin , Yu Miao , Liu Zhizhao , Yin Ruoying , Zhou Shaohui , Zong Lian , Ning Guicai , Xu Xiaoze , Guo Yunqian , Wei Han , Yang Yuanjian 
Published: September 2022

AbstractExtreme torrential rainfall events are low‐probability events. A “China‐Record Extremely Heavy Rainfall” (CREHR) event with rain rate of 201.9 mm/hr occurred on 20 July in Zhengzhou in North China. Using high‐density meteorological observations, ERA5 reanalysis data, remote sensing data from China's FY‐4A satellite, and numerical simulation, we revealed that sufficient warm–humid airflows were continuously transported to the Zhengzhou area via multiple pathways that were mainly modulated by the large‐scale western Pacific subtropical high to the north along with the anomalies of the westerly belt and a meso‐scale binary typhoon system. At the local scale, under the combined action of the vertical circulation that caused low‐level convergence and high‐level divergence, and the rapid uplift of water vapor related to the blocking by mountainous terrain, this CREHR event was eventually triggered. Particularly, our present work shows the roles of both typhoon Cempaka and meso‐scale convective systems to south of Henan province can not be ignored, producing a strong super‐thick water vapor transport layer. The existence of the binary typhoon raises the level of uncertainty involved in the water vapor transport of this CREHR event.
Machine Learning Thermobarometry for Biotite‐Bearing Magmas
Authors: Li Xiaoyan , Zhang Chao 
Published: September 2022

AbstractBiotite (sensu lato) is a widespread rock‐forming mineral in magmatic rocks that can be stable in a broad range of pressure and temperature, but appropriate biotite thermometers or barometers are lacking. Based on a collected experimental dataset (n = 839, T = 625–1,325°C, P = 1–48 kbar) containing biotites that span a wide compositional range [e.g., Mg/(Mg + Fe) = 0–1, TiO2 = 0–9 wt%], we have trained several machine learning algorithms for calibrating a biotite thermobarometer. Our evaluation on model performance reveals that the thermobarometry derived from extremely randomized trees is the best option, which returns coefficients of determination (R2) ≥0.97 for estimating both temperature and pressure using either biotite‐only or biotite + melt model. The model reliability were evaluated using three different approaches for the biotite‐only and biotite + melt thermobarometers respectively, including Monte Carlo cross‐validation (RMSEs are 65°C and 4.7 kbar, 38°C and 3.2 kbar, respectively), testing with independent test set (RMSEs are 54°C and 4.4 kbar, 35°C and 2.4 kbar, respectively), and error propagation from assumed analytical uncertainty (2*MAD are 54°C and 1.27 kbar, 10°C and 1.26 kbar, respectively). Quantified relative importance of involved components in the thermobarometers supports an intrinsic control of thermodynamics in the stability of biotite as a function of pressure and temperature. We applied the new biotite thermobarometer for biotite‐bearing andesitic, phonolitic and rhyolitic volcanic systems provide reliable constraints of temperature and pressure for magma storage, ascent, and evolution. We also offer a user‐friendly webpage for online performance of the thermobarometers (https://lixiaoyan.shinyapps.io/Biotite_thermobarometer/).
Precursory Off‐Fault Deformation in Restraining and Releasing Step Overs: Insights From Discrete Element Method Models
Authors: McBeck J. A. , Ben‐Zion Y. , Zhou X. , Renard F. 
Published: September 2022

AbstractAccelerating geophysical activity is detected preceding some, but not all, large earthquakes. This observation may indicate that no precursors occur before some earthquakes, or that the instrumentation lacks the required sensitivity. To aid crustal monitoring efforts, we use discrete element method models to identify the locations and styles of deformation that may provide useful information about approaching fault reactivation. We model the reactivation of two healed rough faults in a variety of step over configurations, embedded in a host rock with varying amounts of damage subject to shear velocity loading parallel to the faults. Both the fault geometry and ratio of fault to host rock strength control the amount of off‐fault deformation. Consistent with field observations, models with larger steps and more preexisting host rock damage produce higher amounts of off‐fault deformation. We assess the size of the continuous regions of high velocities and strains to compare the value of the precursory information of each velocity and strain component. Comparing the three components of the velocity vector suggests that the fault‐parallel velocity produces the largest and most temporally continuous regions of elevated velocity. The size of these regions increases toward failure, indicating the usefulness of tracking this component. Comparing the volumetric and shear components of the three‐dimensional strain tensor suggests that during most of the interseismic period, the shear strain provides more information about approaching fault slip than the volumetric strain. However, in the days and months preceding fault reactivation, both the shear and volumetric strains provide similarly valuable information.
Brittle Creep and Failure: A Reformulation of the Wing Crack Model
Authors: Bernabé Yves , Pec Matej 
Published: September 2022

AbstractWe propose a reformulation of the wing crack model of brittle creep and failure. Experimental studies suggest that the mechanical interactions of sliding and tensile wing cracks are complex, involving formation, growth, and coalescence of multiple tensile, shear and mixed‐mode cracks. Inspired by studies of failure in granular media, we propose that these complex mechanical interactions lead to the formation of micro shear‐bands, which, in turn, develop longer wing cracks and interact with a wider volume of rock to produce larger shear bands. This process is assumed to indefinitely continue at greater scales. We assume that the original wing crack formalism is applicable to micro shear‐band formation, with the difference that the half‐length, a, of the characteristic micro shear band is allowed to increase with wing crack growth. In this approach, the functional relationship of a with the wing crack length l embodies the entire process of shear band formation, growth and interaction with other shear bands and flaws. We found that the function a(l)/a(0) = 1 + (l/λ)q, where λ and q are constant parameters, generated creep curves consistent with published creep data of rocks. Similar accord was also obtained with experimental brittle failure data. Furthermore, we found that the Mohr‐Coulomb behavior emerged from our model, allowing estimation of the cohesion and angle of internal friction in materials for which λ and q are independently known.
How nature nurtures: Amygdala activity decreases as the result of a one-hour walk in nature
Authors: Sudimac Sonja , Sale Vera , Kühn Simone 
Published: September 2022

AbstractSince living in cities is associated with an increased risk for mental disorders such as anxiety disorders, depression, and schizophrenia, it is essential to understand how exposure to urban and natural environments affects mental health and the brain. It has been shown that the amygdala is more activated during a stress task in urban compared to rural dwellers. However, no study so far has examined the causal effects of natural and urban environments on stress-related brain mechanisms. To address this question, we conducted an intervention study to investigate changes in stress-related brain regions as an effect of a one-hour walk in an urban (busy street) vs. natural environment (forest). Brain activation was measured in 63 healthy participants, before and after the walk, using a fearful faces task and a social stress task. Our findings reveal that amygdala activation decreases after the walk in nature, whereas it remains stable after the walk in an urban environment. These results suggest that going for a walk in nature can have salutogenic effects on stress-related brain regions, and consequently, it may act as a preventive measure against mental strain and potentially disease. Given rapidly increasing urbanization, the present results may influence urban planning to create more accessible green areas and to adapt urban environments in a way that will be beneficial for citizens’ mental health.
Targeted demethylation at ZNF154 promotor upregulates ZNF154 expression and inhibits the proliferation and migration of Esophageal Squamous Carcinoma cells
Authors: He Wenting , Lin Shiyong , Guo Yi , Wu Yuanzhong , Zhang Lu-Lu , Deng Qiling , Du Zi-Ming , Wei Mingbiao , Zhu Weijie , Chen Wan-Juan , Shao Jian-Yong , Xu Guo-Liang 
Published: September 2022

AbstractZinc finger protein 154 (ZNF154) is hypermethylated at the promoter in many epithelial-derived solid tumors. However, its methylation status and function in esophageal squamous carcinoma (ESCC) are poorly understood. We found that the ZNF154 promoter is hypermethylated in ESCC and portends poor prognosis. In addition, ZNF154 functions as a tumor suppressor gene (TSG) in ESCC, and is downregulated by promoter hypermethylation. We established a targeted demethylation strategy based on CRISPR/dCas9 technology and found that the hypermethylation of ZNF154 promoter repressed ZNF154 induction, which in turn promoted the proliferation and migration of ESCC cells in vitro and in vivo. Finally, high-throughput CUT&Tag analysis, GEPIA software and qPCR were used to revealed the role of ZNF154 as a transcription factor to upregulate the expression of ESCC-associated tumor suppressor genes. Taken together, hypermethylation of the ZNF154 promoter plays an important role in the development of ESCC, and epigenetic editing is a promising tool for inhibiting ESCC cells with aberrant DNA methylation.
Ten years of dynamic consent in the CHRIS study: informed consent as a dynamic process
Authors: Mascalzoni Deborah , Melotti Roberto , Pattaro Cristian , Pramstaller Peter Paul , Gögele Martin , De Grandi Alessandro , Biasiotto Roberta 
Published: September 2022

AbstractThe Cooperative Health Research in South Tyrol (CHRIS) is a longitudinal study in Northern Italy, using dynamic consent since its inception in 2011. The CHRIS study collects health data and biosamples for research, and foresees regular follow-ups over time. We describe the experience with the CHRIS study dynamic consent, providing an overview of its conceptualization and implementation, and of the participant-centered strategies used to assess and improve the process, directly linked to participation and communication. In order to comply with high ethical standards and to allow broadness in the areas of research, CHRIS dynamic consent was conceived as an interactive process: based on a strong governance and an ongoing tailored communication with participants, it aims to promote autonomy and to develop a trust-based engaged relationship with participants, also relevant for retention. Built within an online platform, the consent allows granular choices, which can be changed over time. In a process of co-production, participants views have been investigated and kept into account in policy development. Participants showed a high degree of participation, thus enabling the consolidation of the CHRIS resources. Even though a low change rate was reported in the baseline, participants valued the possibility of changing their informed consent choices. Communication (language-tailored, ongoing, multimedia) was important for participants, and for participation and retention. In our experience, dynamic consent was proven to be a flexible consent model, which allowed to meet ethical and legal standards for participation in research, and to accommodate participants’ and researchers’ needs.
Rapid retreat of Thwaites Glacier in the pre-satellite era
Authors: Graham Alastair G. C. , Wåhlin Anna , Hogan Kelly A. , Nitsche Frank O. , Heywood Karen J. , Totten Rebecca L. , Smith James A. , Hillenbrand Claus-Dieter , Simkins Lauren M. , Anderson John B. , Wellner Julia S. , Larter Robert D. 
Published: September 2022

AbstractUnderstanding the recent history of Thwaites Glacier, and the processes controlling its ongoing retreat, is key to projecting Antarctic contributions to future sea-level rise. Of particular concern is how the glacier grounding zone might evolve over coming decades where it is stabilized by sea-floor bathymetric highs. Here we use geophysical data from an autonomous underwater vehicle deployed at the Thwaites Glacier ice front, to document the ocean-floor imprint of past retreat from a sea-bed promontory. We show patterns of back-stepping sedimentary ridges formed daily by a mechanism of tidal lifting and settling at the grounding line at a time when Thwaites Glacier was more advanced than it is today. Over a duration of 5.5 months, Thwaites grounding zone retreated at a rate of >2.1 km per year—twice the rate observed by satellite at the fastest retreating part of the grounding zone between 2011 and 2019. Our results suggest that sustained pulses of rapid retreat have occurred at Thwaites Glacier in the past two centuries. Similar rapid retreat pulses are likely to occur in the near future when the grounding zone migrates back off stabilizing high points on the sea floor.
Colonization dynamics of extended-spectrum beta-lactamase-producing Enterobacterales in the gut of Malawian adults
Authors: Lewis Joseph M. , Mphasa Madalitso , Banda Rachel , Beale Mathew A. , Heinz Eva , Mallewa Jane , Jewell Christopher , Faragher Brian , Thomson Nicholas R. , Feasey Nicholas A. 
Published: September 2022

AbstractDrug-resistant bacteria of the order Enterobacterales which produce extended-spectrum beta-lactamase enzymes (ESBL-Enterobacterales, ESBL-E) are global priority pathogens. Antimicrobial stewardship interventions proposed to curb their spread include shorter courses of antimicrobials to reduce selection pressure but individual-level acquisition and selection dynamics are poorly understood. We sampled stool of 425 adults (aged 16–76 years) in Blantyre, Malawi, over 6 months and used multistate modelling and whole-genome sequencing to understand colonization dynamics of ESBL-E. Models suggest a prolonged effect of antimicrobials such that truncating an antimicrobial course at 2 days has a limited effect in reducing colonization. Genomic analysis shows largely indistinguishable diversity of healthcare-associated and community-acquired isolates, hence some apparent acquisition of ESBL-E during hospitalization may instead represent selection from a patient’s microbiota by antimicrobial exposure. Our approach could help guide stewardship protocols; interventions that aim to review and truncate courses of unneeded antimicrobials may be of limited use in preventing ESBL-E colonization.
Single-particle cryo-EM structures from iDPC–STEM at near-atomic resolution
Authors: Lazić Ivan , Wirix Maarten , Leidl Max Leo , de Haas Felix , Mann Daniel , Beckers Maximilian , Pechnikova Evgeniya V. , Müller-Caspary Knut , Egoavil Ricardo , Bosch Eric G. T. , Sachse Carsten 
Published: September 2022

AbstractIn electron cryomicroscopy (cryo-EM), molecular images of vitrified biological samples are obtained by conventional transmission microscopy (CTEM) using large underfocuses and subsequently computationally combined into a high-resolution three-dimensional structure. Here, we apply scanning transmission electron microscopy (STEM) using the integrated differential phase contrast mode also known as iDPC–STEM to two cryo-EM test specimens, keyhole limpet hemocyanin (KLH) and tobacco mosaic virus (TMV). The micrographs show complete contrast transfer to high resolution and enable the cryo-EM structure determination for KLH at 6.5 Å resolution, as well as for TMV at 3.5 Å resolution using single-particle reconstruction methods, which share identical features with maps obtained by CTEM of a previously acquired same-sized TMV data set. These data show that STEM imaging in general, and in particular the iDPC–STEM approach, can be applied to vitrified single-particle specimens to determine near-atomic resolution cryo-EM structures of biological macromolecules.
Theoretical investigation of hybrid nanomaterials transient flow through variable feature of Darcy–Forchheimer space with exponential heat source and slip condition
Authors: Ullah Ikram , Alajlani Yahya , Pasha Amjad Ali , Adil Mohammad , Weera Wajaree 
Published: September 2022

AbstractNanomaterials have achieved remarkable importance in cooling small electronic gadgets like akin and microchips devices. The role of nanoparticles is essential in various aspects, especially in biomedical engineering. Thus hybrid nanomaterials is introduced to strengthen the heat exchangers' performance. In view of the above practical and existing applications of nanomaterials. Our aim is to examine the consequences of Darcy–Forchheimer's radiative and Hall current flow of nanomaterials over a rotating porous disk with variable characteristics. Stretching disk accounting for the slip condition. Nanoparticles ZnO and CoF2O4 are dispersed in based fluid water. The present model is utilized for thermo-physical attributes of hybrid nanomaterials with the impact of shape factor. Transformations convert the modeled PDEs into ODEs. The obtained highly non-linear system is tackled numerically by the NDSolve technique through the software Mathematica. The outcomes of significant variables against different profiles are executed and elaborated in detail. Obtained results show that both nano and hybrid nanofluid radial velocity have reverse behavior against variable porosity and permeability parameters, whereas it decays for larger Forchheimer numbers. Further, it is worthy to point out that, hybrid nanophase has a higher impact on distinct profiles when compared with nano and common liquid phases.
Highly time-resolved 4D MR angiography using golden-angle radial sparse parallel (GRASP) MRI
Authors: Goldman-Yassen Adam E. , Raz Eytan , Borja Maria J. , Chen Duan , Derman Anna , Dogra Siddhant , Block Kai Tobias , Dehkharghani Seena 
Published: September 2022

AbstractCurrent dynamic MRA techniques are limited by temporal resolution and signal-to-noise penalties. GRASP, a fast and flexible MRI technique combining compressed-sensing, parallel imaging, and golden-angle radial sampling, acquires volumetric data continuously and can be reconstructed post hoc for user-defined applications. We describe a custom pipeline to retrospectively reconstruct ultrahigh temporal resolution, dynamic MRA from GRASP imaging obtained in the course of routine practice. GRASP scans were reconstructed using a custom implementation of the GRASP algorithm and post-processed with MeVisLab (MeVis Medical Solutions AG, Germany). Twenty consecutive examinations were scored by three neuroradiologists for angiographic quality of specific vascular segments and imaging artifacts using a 4-point scale. Unsubtracted images, baseline-subtracted images, and a temporal gradient dataset were available in 2D and 3D reconstructions. Distinct arterial and capillary phases were identified in all reconstructions, with a median of 2 frames (IQR1-3 and 2–3, respectively). Median rating for vascular segments was 3 (excellent) in all reconstructions and for nearly all segments, with excellent intraclass correlation (range 0.91–1.00). No cases were degraded by artifacts. GRASP-MRI obtained in routine practice can be seamlessly repurposed to produce high quality 4D MRA with 1–2-s resolved isotropic cerebrovascular angiography. Further exploration into diagnostic accuracy in disease-specific applications is warranted.
Anatomical network analyses reveal evolutionary integration and modularity in the lizards skull
Authors: Asakura Yuya , Kawabe Soichiro 
Published: September 2022

AbstractThe morphology of lizard skulls is highly diverse, and it is crucial to understand the factors that constrain and promote their evolution to understand how lizards thrive. The results of interactions between cranial bones reflecting these factors can be detected as integration and modularity, and the analysis of integration and modularity allows us to explore the underlying factors. In this study, the integration and modularity of the skulls of lizards and the outgroup tuatara are analyzed using a new method, Anatomical Network Analysis (AnNA), and the factors causing lizards morphological diversity are investigated by comparing them. The comparison of modular structures shows that lizard skulls have high integration and anisomerism, some differences but basically common modular patterns. In contrast, the tuatara shows a different modular pattern from lizards. In addition, the presence of the postorbital bar by jugal and postorbital (postorbitofrontal) also reflect various functional factors by maintaining low integration. The maintenance of basic structures due to basic functional requirements and changes in integration within the modules play a significant role in increasing the morphological diversity of the lizard skull and in the prosperity of the lizards.