bluuebunny/crossref_metadata_2025_split huggingface dataset:
A constant pressure flowmeter for extreme-high vacuum
Authors: Eckel S , Barker D S , Fedchak J , Newsome E , Scherschligt J , Vest R 
Published: June 2022

Abstract
We demonstrate operation of a constant-pressure flowmeter capable of generating and accurately measuring flows as low as 2 × 10−13 mol s−1. Generation of such small flows is accomplished by using a small conductance element with C ≈ 50 nl s−1. Accurate measurement then requires both low outgassing materials (

<
1
×
1

0

−
15

mol s−1) and small volume changes (

≈
70

μl). We outline the present flowmeter’s construction, detail its operation, and quantify its uncertainty. The type-B uncertainty is

<
0.2

% (k = 1) over the entire operating range. In particular, we present an analysis of its hydraulic system, and quantify the shift and uncertainty due to the slightly compressible oil. Finally, we compare our flowmeter against a NIST standard flowmeter, and find agreement to within 0.5% (k = 2).
Right large deviation principle for the top eigenvalue of the sum or product of invariant random matrices
Authors: Mergny Pierre , Potters Marc 
Published: June 2022

Abstract
In this note we study the right large deviation of the top eigenvalue (or singular value) of the sum or product of two random matrices A and B as their dimensions goes to infinity. We consider a general framework containing the cases where A and/or B are taken from an invariant ensemble or are fixed diagonal matrices. We show that the tilting method introduced in Guionnet and Maïda (2020 Electron. J. Probab.
25 1–24) can be extended to our general setting and is equivalent to the study of a spherical spin glass model specific to the operation—sum of symmetric matrices/product of symmetric matrices/sum of rectangular matrices—we are considering.
Implementation of the school literacy movement development stage in fostering secondary school students’ mathematical literacy skills
Authors: Sopiany Hanifah Nurus , Turmudi  , Juandi Dadang , Sari Rika Mulyati Mustika 
Published: June 2022

AbstractThis is a further research from the previous study which describes the situation of how the school literacy movement activities at the habituation stage were implemented which was carried out by the researchers in early 2020. This research is a situation analysis on the implementation of school literacy movement activities at the development stage which becomes a part of Indonesian government program in Strengthening Character Education. The growth and development of students’ mathematical literacy is one of the final objectives of the series researches being conducted. Teachers in secondary schools around North Cimahi region were involved as research subject in this study. The data of this research were collected through questionnaires and interviews. The results presented are divided into two parts, namely: the result of general literacy development and the result of mathematical literacy development.
Quadratic Bezier Curve as the base for pot modelling
Authors: Mutimmah Dzurotul , Prayekti Novi 
Published: June 2022

Abstract
Pot is a place or container made of clay, earthenware, cement, or plastic to plant trees or plants. In addition to a place to plant plants, pots also function to decorate the appearance of the house, both on the outside (outdoor) or in the room (indoor). So that the selection of the right pot model can make the yard or corner of the room look more comfortable, beautiful, and attractive. Some pot models that are already on the market have a circular or rectangular base with a monotonous pot shape. Thus, the researcher conducted on the pot modelling with the initial data of regular hexagon polygons as the base of the pot and the Quadratic Bezier curve as the basis for modelling pots with the help of Maple software. This research method uses applied research methods, namely the application of the Quadratic Bezier Curve in making pot models, several pot models were produced, namely a pot with two tiers and three tiers, where each level has several potted models with twisted and symmetrical types. So that the pot models obtained are more attractive and have artistic value.
Metric dimension of vertex shackle operation result graph on wheel and star graphs
Authors: Saifudin Ilham , Umilasari Reni , Jalil Abdul 
Published: June 2022

Abstract
The ordered set W = (w1, w2, w3,…, wk
} of vertex set on graph G and a vertex v in G the it form k-vector ordered r(v|W) = (d(v, w1
), d(v, w2
),…, (v, wk
)) is set of metric coordinate by v to W. W can be said as resolving set of G if every coordinate of W are not same. The number of resolving set or basis of G which minimum is called metric dimension and written by dim(G). Shackle is one technique to construct a graph by attach the vertex or edge between the same graph then it make linkage vertex and edge vertex that every graph which constructed be denoted by Shack(G, v, t) and Shack(G, e, t) means a shackle graph consist of t copy with t > 2. In this study case, we determine metric dimension of vertex shackle products graphs of wheel graph Shack(Wm, v, n) for m > 3, n > 2 and vertex shackle products of star graph Shack(Sm, v, n) for m > 3 and n > 2. In addition, we also determined the implementation of metric dimension theory by finding the coordinate of drone as navigation for traffic monitoring in Jember Regency.
Alternative solution optimization quadratic form with fuzzy number parameters
Authors: Sugiyarto  
Published: June 2022

Abstract
The fuzzy number is one of the alternatives to maximize solving a quadratic model programming problem. Based on that statement, this paper provides one of the methods to solve the quadratic model programming problem. It started with a general discussion on quadratic model programming and continued by transposing a basic form into a fuzzy quadratic programming equation and giving a reference to solve that problem. Finally, a few examples are provided to analyse how accurate this method works.
1071 INCIDENCE OF RECORDED OSTEOPOROSIS, OSTEOPENIA AND FRAGILITY FRACTURE IN OLDER PEOPLE: ANALYSIS OF UK PRIMARY CARE DATA
Authors: Avgerinou C , Petersen I , Clegg A , West R M , Osborn D , Walters K 
Published: June 2022

Abstract

Introduction
Osteoporosis is common in later life, leading to fragility fractures associated with increased mortality, disability, and costs. There is a surprising lack of data regarding the incidence of osteoporosis. We aimed to estimate the incidence of recorded diagnosis of osteoporosis, osteopenia, and fragility fracture in older people, explore time trends in diagnosis, and differences by age, sex, and social deprivation.

Method
We used de-identified patient data provided as part of routine primary care (IQVIA Medical Research Database (IMRD). All patients aged 50-99y registered with THIN (The Health Improvement Network) participating practices between 1/1/2000–31/12/2018 were included. Crude incidence rates (IR) were estimated per 10,000 person-years (PY). We used Poisson regression to calculate adjusted Incidence Rate Ratios (IRR) accounting for sex, age, calendar year and deprivation.

Results
The IR of osteoporosis was significantly higher in women, 84.32 (95%CI 83.81–84.83) vs. 16.66 (95%CI 16.43–16.90) in men per 10,000PY. In women, recorded IR of osteoporosis reached a peak in 2009. In the adjusted model, older men in most deprived areas had a higher IRR of osteoporosis [1.67 (95% 1.59–1.74)] compared to those in least deprived areas. Women were more likely to be diagnosed with osteopenia compared to men, at any age. Incidence of osteopenia diagnosis increased over time. In the adjusted model, men in most deprived areas had a higher IRR of osteopenia [1.44 (95%CI 1.35–1.53)] compared to least deprived areas. The IR of fragility fracture was higher in women, 84.97 (95%CI 84.45–85.48) vs. 31.15 (95%CI 30.83–31.48) in men per 10,000PY. In the adjusted model, men in most deprived areas had an increased IRR of fragility fracture [1.53 (95%CI 1.48–1.59)] compared to least deprived areas.

Conclusion
Community bone health interventions might be targeted at populations at higher risk of fragility fractures, including older men living in socially deprived areas.
1027 DEVELOPING A MINIMUM COMMON DATASET FOR HIP FRACTURE AUDIT
Authors: Poacher A , Ojeda-Thies C , Hall A , Ahern E , Brent L , Costa M , Johansen A 
Published: June 2022

Abstract

Introduction
National hip fracture audits share a common heritage in the work of Rikshöft and the Standardised Audit of Hip Fracture in Europe. However, as more countries develop audit programmes and these evolve to address local needs, divergence in the data they collect compromises their scope for learning from clinical, audit and quality improvement work in other nations.

Method
In 2021 we compared all ten established national hip fracture audits: England/Wales/Northern Ireland; Scotland; Australia/New Zealand; Ireland; Germany; the Netherlands; Sweden; Norway; Denmark; Spain. We tabulated all questions included in each, and cross-referenced them against the 32 questions of the minimum common dataset (MCD) defined by the global Fragility Fracture Network (FFN) in 2014. We identified those consistently used in most national audits, and additional fields that might need to form part of a revised MCD. Any MCD must meet the needs of both developed and developing countries. We presented these findings at the Asia-Pacific FFN meeting, and used an online questionnaire to capture feedback from different countries. A draft revision was presented at the Global FFN conference in September 2021, with feedback again used to finalise this revised MCD.

Results
We tabulated a total of 215 possible questions. Only 72 (34%) were used in &gt;1 national audit, and only 32 (15%) by more than half of audits. Adherence to the 2014 MCD was disappointing; all 32 fields were used by at least one audit, but 5/32 only by one audit. Only 21/32 (65%) were used in the majority, and only three (anaesthetic grade, operation and date/time of surgery) by all ten established audits.

Discussion
This revised MCD will help aspirant nations establish new audit programmes, facilitate the integration of novel analytic techniques and greater multinational collaboration, and serve as an internationally-accepted standard for monitoring and improving hip fracture services.
942 THE POST-OPERATIVE RISKS OF STOMA FORMATION IN THE COGNITIVELY IMPAIRED
Authors: Jarratt-Barnham I 
Published: June 2022

Abstract

Introduction
Over 20,000 stomas are formed in the UK annually, many for geriatric patients. However, formation both requires significant surgical intervention and leaves patients with the substantial post-operative burden of stoma care. Such is this care’s complexity, 70% of all stoma patients experience complication. Patients with cognitive impairment may be at particular risk of poor outcomes following stoma formation. However, the impact of cognitive impairment on patient suitability for stoma formation is under-discussed in the literature. We conducted a preliminary literature review to identify factors for to be considered when proposing stoma formation in this patient group.

Method
A preliminary literature review searching several databases (PubMed, Cochrane and Embase) was conducted using pre-devised search terms. A further manual search was then performed reviewing the references of identified papers of interest. Arguments relevant to stoma formation in elderly patients with cognitive impairment were extracted.

Results
Little quantitative evidence surrounding stoma formation in the cognitively impaired was found. However, four key risks for these patients were identified: 1) Patients with cognitive impairment, particularly dementia, experience higher rates of perioperative complication following surgery. 2) Cognitively impaired patients are at increased risk of post-operative stoma complications, precipitated by poor stoma care. These complications are also more likely to be uncommonly advanced on presentation due to poor patient surveillance. 3) The need for regular stoma care can necessitate unwanted nursing home admission. 4) Cognitively impaired patients are particularly vulnerable to psychological distress following stoma formation due to reduced ability to adapt to and participate in their stoma’s care.

Conclusion
This preliminary review identified several factors to be considered when determining suitability for stoma formation in a cognitively impaired patient. However, little quantitative research exploring this association was identified. Further work is required to better characterise the risks posed by stoma formation in this patient group.
945 EFFECTIVENESS OF CREATINE SUPPLEMENTATION ON MEMORY IN HEALTHY INDIVIDUALS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Prokopidis K , Giannos P , Triantafyllidis K K , Kechagias K 
Published: June 2022

Abstract

Introduction
The benefit of creatine monohydrate supplementation in improving memory performance in healthy humans is unclear. The aim of this study was to determine the effectiveness of creatine monohydrate supplementation on memory performance in healthy humans.

Method
A literature search of PubMed, Web of Science, Cochrane Library, and Scopus for randomized clinical trials (RCTs) published from database inception until September 30, 2021, examining the effects of creatine supplementation on measures of memory in healthy humans was conducted. The control groups consisted of placebo. The main outcome was performance measures of memory that were further examined according to age, sex, treatment duration, and dose of creatine monohydrate supplementation.

Results
Ten RCTs met the inclusion criteria and 8 were included in the meta-analysis. Overall, creatine supplementation improved memory compared to placebo (SMD: 0.29, 95% CI: 0.04–0.53, I2 = 66%, P = 0.02). Subgroup analyses revealed a significant improvement on memory in older adults (66–76 years) (SMD: 0.88, 95% CI: 0.22–1.55, I2 = 83%, P = 0.009). Creatine dose, duration of intervention, and sex did not influence the findings.

Conclusion
These data support that the use of creatine monohydrate supplementation enhances memory performance in healthy humans compared to placebo, especially in older adults. However, caution is warranted due to the combination of various assessment tools designed to measure memory, which would increase the heterogeneity of the data.
959 OPTIMISING MEDICAL CARE IN OLDER EMERGENCY UROLOGY PATIENTS USING A GERIATRICIAN-LED PERI-OPERATIVE SERVICE
Authors: Lam R , Dhesi J , Forsyth E , Streeter E , Kommu S , Thomas M , Meilak C 
Published: June 2022

Abstract

Introduction
Older and frail patients account for a large proportion of urology service use (Drch GW, Griebling TL., JAGS, 2003; 51: S355–8). Frail patients are at higher risk of complications and readmissions (Suskind A et al., BJUI, 2016; 117:836–42). Emergency patients may not be optimised before admission, leading to further increased risk and time restraints on care planning. Therefore, a geriatrician-led Perioperative Care for Older People Undergoing Surgery (POPS) service was established within the urology department at a District General Hospital to improve older emergency urology inpatients’ outcomes. We reviewed the impact on medical management, readmissions, and care planning.

Method
Retrospective documentation review of emergency urology patients aged over 65 admitted in the 3 months before the POPS service implementation, compared to those reviewed by POPS in the 3 months following. Median clinical frailty score of the POPS group was 6. The Comprehensive Geriatric Assessment based inpatient perioperative service was created using co-design and staff questionnaires were completed post-implementation.

Results
100% of staff (n = 26) would recommend POPS to other surgical wards and comments on improvements focused on expansion (9/15).

Conclusion
The POPS service significantly improved the recognition and management of medical conditions and reduced medical readmissions. Increased end of life recognition and planning allowed patients’ wishes to be acted on. This service was successfully implemented with high staff acceptance.
967 USING CLINICAL INFORMATICS TO IMPROVE OUTCOMES AND PATIENT EXPERIENCE FOR ADMISSIONS TO WWL WITH PD AND RELATED CONDITIONS
Authors: Alicehajic-Becic D 
Published: June 2022

Abstract

Introduction
Patients with PD depend on timely administration of their regular medication regimen to optimise their motor function. Using Clinical Informatics Database to allow analysis of medication doses, a service evaluation of PD and related conditions was undertaken using QI methodology with a particular focus on omitted and delayed doses. Alongside this, prospective qualitative data capture took place on patients’ experience during hospital stay. The impact of specialist team was also analysed.

Method
Using electronic prescribing records, a database of all doses for co-beneldopa was used as a starting point of identifying gaps and areas for improvement. Various interventions were implemented to address these using QI methodology. Ongoing mechanism for data capture was developed to analyse the results. Patient experience via data capture questionnaire was sought on how the changes affected their experience of hospital stay. Specialist team input was anlaysed using report on ‘PD Team’ notes.

Results
The percentage of omissions had a mean of 10.8% from the 19,462 doses of co-beneldopa analysed while the delays in administration improved from initial figure of 40% in 2019 to 34.7% although the trend in 8 months of 2021 increased back up to 39% (17,313 doses of co-beneldopa). The overall total percentage of co-beneldopa doses administered had also increased (88%, 90% and 90.4% for 2019, 2020 and 2021 (Jan-Aug)). Patients reported different views on medicines management during hospital stay. PD team input more than tripled between 2019 and 2020 (192 vs 611notes) with 421 placed in 2021 up to Aug.

Conclusion
Clinical Informatics data can be used to improve patient pathways and improve outcomes. Further work on patient experience will be completed to ensure their feedback is incorporated into future pathway design. Specialist input is essential in safe care of PD patients.
970 FRAILTY IS INVERSELY CORRELATED WITH SERUM ALBUMIN IN ACUTE HIP FRACTURE
Authors: Pathmanathan K , Mubin M , Sevilla C , Zaman M , Chan R , Hussain M , Brown E , McDevitt G , Khan R , Nandi A , Mukherjee B , Obiechina N 
Published: June 2022

Abstract

Introduction
Frailty and sarcopenia have been shown to significantly increase the risk of falls, traumatic hip fractures and all-cause mortality in the elderly. The assessment of frailty using a validated clinical frailty scale such as that proposed by Rockwood et al., therefore, continues to remain an important step in determining post-operative prognosis in patients undergoing hip fracture surgery. The purpose of this study was to examine the relationship between frailty and serum albumin—an independent biochemical predictor of survival in hip fracture patients (1).

Method
This retrospective cross-sectional study analysed 190 patients, aged above 60 years, admitted to Queen’s Hospital Burton (QHB) between the 1st January and 28th December 2019 with a newly diagnosed hip fracture. Pre-operative serum albumin levels (g/L) and Rockwood clinical frailty scores (rCFS) were recorded from electronic medical records (EMR). Using the SPSS 27 statistical package, Pearson’s correlation co-efficient and linear regression analysis were carried out using these variables.

Results
A total of 190 patients were included in the study (57 male, 133 female). Mean patient age was 82.2 ± 8.47 years. More than 50% of patients had a Rockwood CFS ≥5. Mean serum albumin (g/L) was 37.3 ± 6.56. A statistically significant inverse correlation was demonstrated between pre-operative serum albumin levels and Rockwood CFS (r = −0.243, p &lt; 0.001).

Conclusion
This study showed how serum albumin, a negative acute phase reactant and marker of chronic malnutrition, is inversely associated with frailty in hip fracture patients and the important role of Rockwood CFS and pre-operative serum albumin levels in the prognostication of hip fractures in the elderly. References 1) Bohl D, Shen M, Hannon C, Fillingham Y, Darrith B, Della Valle C. Serum Albumin Predicts Survival and Postoperative Course Following Surgery for Geriatric Hip Fracture. Journal of Bone and Joint Surgery. 2017;99(24):2110–2,118.
972 EXPLORING THE IMPACT OF FRAILTY FOLLOWING TRAUMA: AN ANALYSIS OF EMERGENCY DEPARTMENT (ED) MANAGEMENT AND LONG TERM OUTCOMES
Authors: Cuthbertson R , Ellis K , Reda E , Chaplow K , Gordon M W G , Capek E 
Published: June 2022

Abstract

Introduction
Major trauma represents a large number of hospital presentations in Scotland. 1 We aimed to: -Describe the population of ‘major trauma’ patients presenting to the Emergency Department of QEUH, Glasgow -Compare assessment, management and clinical outcomes in frail versus non-frail patients with trauma.

Method
This was a retrospective, cohort study. Patients were identified using the Scottish Trauma Audit Group (STAG) database. 2 Patients aged over 18, admitted between 01/11/18 and 31/01/19 were included. STAG data was supplemented by individual case note review. Clinical Frailty Scale (CFS) and Charlson Comorbidity Index (CCI) were calculated.

Results
203 patients (173 non-frail, 30 frail) were included. Median age was 58 years (range 19–98). Isolated head injuries were the predominant injury type in frail patients (36.7%) versus polytrauma in non-frail cohort (44.5%). Injury Severity Score (ISS) was similar across both groups (median score: 10v9.5). CCI score correlated well with frailty. Frail patients were less likely to:
-Have ambulance pre-alert call (10% v 28%, p = 0.041).
-Be managed in ‘Resus’ (17% v 54%, p &lt; 0.05).
-Have consultant-led care in ED (6.6% v 36.4%, p = 0.001).
-Undergo CT within 60 minutes (10% v 34.7%, p = 0.0095).
They were more likely to be admitted under a Medical Team (20% v 2.9%, p &lt; 0.05). Frailty was associated with poorer outcomes:
-Mortality 30% v 9.8%: significant difference in unadjusted, 1-year survival curves (Log-rank test p = 0.0026). Frailty carried a hazard-ratio of death of 5.02 (CI:2.13–11.79, p = 0.0002) compared to non-frailty through the first year after trauma.
-Longer median Length of Stay: 22 v 8 days.

Conclusion
We identified poorer clinical outcomes in our frail patient cohort. Despite this, and with similar ISS scores across both groups, our data would suggest a tendency to under-recognise significant trauma in Frail patients. References [1] Audit of Trauma Management in Scotland. Public Health Scotland, 2021 [2] Scottish Trauma Audit Group https://www.stag.scot.nhs.uk/