bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience of 300 Cases of Prenatal Fetoscopic Open Spina Bifida Repair: Report of the International Fetoscopic Neural Tube Defect Repair Consortium
Authors: Sanz Cortes M. , Chmait R.H. , Lapa D.A. , Belfort M.A. , Carreras E. , Miller J.L. , Brawura Biskupski Samaha R. , Sepulveda Gonzalez G. , Gielchinsky Y. , Yamamoto M. , Persico N. , Santorum M. , Otaño L. , Nicolaou E. , Yinon Y. , Faig-Leite F. , Brandt R. , Whitehead W. , Maiz N. , Baschat A. , Kosinski P. , Nieto-Sanjuanero A. , Chu J. , Kershenovich A. , Nicolaides K.H. 
Published: September 2022

(Am J Obstet Gynecol. 2021;225:678.e1–678.e11. [Epub June 3, 2021])
Prenatal repair of open spina bifida (OSB) showed increased chance of independent ambulation and increased outcomes of ventriculoperitoneal shunting compared with postnatal repair in a multicenter randomized controlled trial in the Management of Myelomeningocele Study (MOMS). The technique, involving a hysterotomy, has risks regarding the uterine incision used. Due to the risks, fetal surgeons worldwide have been attempting to repair OSB using minimally invasive techniques to mitigate adverse outcomes and improve neonatal neurologic benefits. One such technique is fetoscopic OSB repair.
Nirsevimab for Prevention of RSV in Healthy Late-preterm and Term Infants
Authors: Hammitt L.L. , Dagan R. , Yuan Y. , Baca Cots M. , Bosheva M. , Madhi S.A. , Muller W.J. , Zar H.J. , Brooks D. , Grenham A. , Wählby Hamrén U. , Mankad V.S. , Ren P. , Takas T. , Abram M.E. , Leach A. , Griffin M.P. , Villafana T. ,   MELODY Study Group
Published: September 2022

(N Engl J Med. 2022;386:837–846. doi: 10.1056/NEJMoa2110275)
Infants experience medically attended illness and hospitalization at elevated rates from respiratory syncytial virus (RSV) infection. As a monoclonal antibody with an extended half-life, Nirsevimab (N) is an emerging treatment that binds to the RSV fusion protein and has enhanced inhibitory potency for RSV in cell-culture and animal models over Palivizumab. Preterm (29 to <35 wk gestational age birth) infants receiving a single dose of N before RSV season showed 70.1% efficacy at protection against RSV with a favorable safety profile. The safety and efficacy of N in late-preterm and term infants entering their first RSV season is investigated in this phase 3 trial.
Prediction of Severe Adverse Neonatal Outcomes at the Second Stage of Labor Using Machine Learning: A Retrospective Cohort Study
Authors: Guedalia J. , Sompolinsky Y. , Novoselsky Persky M. , Cohen S.M. , Kabiri D. , Yagel S. , Unger R. , Lipschuetz M. 
Published: September 2022

(BJOG. 2021;128:1824–1832)
During the second stage of labor, close maternal and neonatal monitoring is important for avoiding adverse outcomes. Machine learning has been used to analyze complex data patterns and has successfully predicted the need for emergent cesarean delivery (CD) and successful vaginal birth after CD. This study aimed to develop a model to predict adverse neonatal outcomes based on data available to clinicians before the onset of the second stage of labor using machine learning tools.
The Effect of Mode of Delivery and Duration of Labor on Subsequent Pregnancy Outcomes: A Retrospective Cohort Study
Authors: Van Winsen K.D. , Savvidou M.D. , Steer P.J. 
Published: September 2022

(BJOG. 2021;128:2132–2139. [Epub August 30, 2021])
Gestational length of a pregnancy is varied with maternal age, medical conditions, race, and socioeconomic factors contributing. Highly correlated gestational length in subsequent pregnancies suggests that constitutional factors may also influence pregnancy outcomes. This study aimed to determine the method of delivery and labor duration of a first singleton labor on the subsequent pregnancy outcomes, including gestational length, method of delivery, and neonatal outcome.
Multicenter Study Evaluating Nitrous Oxide Use for Labor Analgesia at High- and Low-altitude Institutions
Authors: Wood C. , Arbet J. , Amura C. , Nodine P. , Collins M. , Orlando B. , Mayer D. , Stein D. , Anderson J. 
Published: September 2022

(Anesth Analg. 2022;124:294–302)
The United States has used nitrous oxide as a labor analgesia since the 1940s because it has no impact on uterine myometrial contractility, it has little impact on maternal hemodynamics and respiration, and it is a noninvasive procedure. However, most medical professionals still prefer neuraxial analgesia. Previous studies report that 40% nitrous oxide successfully decreased pain and increased maternal satisfaction during labor compared with a placebo at sea level, but there are no studies evaluating the effect of nitrous oxide on maternal pain relief or satisfaction in high altitudes. Because of the partial pressure gas law, as elevation increases, the study hypothesized gas analgesia administration had less of an effect than at sea level, both in pain relief and side effects. This study evaluated altitude's effect on nitrous oxide administration by comparing high altitude and low altitude births.
Neuraxial Labor Analgesia Failure Rates in Women With a Body Mass Index ≥50 kg/m2: A Single-center Retrospective Study
Authors: Arnolds D. , Scavone B. 
Published: September 2022

(Int J Obstet Anesth. 2021;48:103176)
Rates of emergency cesarean delivery (CD) are higher in obstetric patients with a body mass index (BMI) of 50 kg/m2 or more, known as super obesity. Reliable neuraxial techniques are needed in the event of emergency CD. While combined spinal-epidural technique results in a lower proportion of catheters replaced than epidurals without dural puncture (EPI) in the general population, it is not clear if this is also true for super-obese patients. This study aimed to determine the failure rate of first neuraxial catheter placement for labor analgesia in super-obese parturients.
Intrathecal 2-Chloroprocaine 3% Versus Hyperbaric Bupivacaine 0.75% for Cervical Cerclage: A Double-blind Randomized Controlled Trial
Authors: Lee A. , Shatil B. , Landau R. , Menon P. , Smiley R. 
Published: September 2022

(Anesth Analg. 2022;134:624–632)
Cervical cerclage, an operation designed to reduce preterm delivery and improve perinatal outcomes, often utilizes spinal anesthesia. While the benefits of spinal anesthesia are well documented, an intrathecal local anesthetic agent, such as 2-chloroprocaine (2-CP), could shorten postanesthesia care unit stay as it has a fast onset and short duration. Currently, bupivacaine is commonly used during spinal anesthesia because of historical concern regarding 2-CP’s safety. This study randomly compared the outcome of 2-CP 3% 50 mg and hyperbaric bupivacaine 0.75% 9 mg on dermatomal level, sensory block resolution, ability to ambulate and void, and motor blockade.
Accuracy of Cricothyroid Membrane Identification Using Ultrasound and Palpation Techniques in Obese Obstetric Patients: An Observational Study
Authors: Lavelle A. , Drew T. , Fennessy P. , McCaul C. , Shannon J. 
Published: September 2022

(Int J Obstet Anesth. 2021;48:103205)
Emergency front of neck access (e-FONA) is a potentially life-saving intervention but requires the accurate identification of the cricothyroid membrane (CTM). CTM identification failure is most common in obese females, who also have an increased risk of emergency and elective cesarean delivery. This study aimed to compare accuracy of CTM identification using ultrasound (US) compared with palpation in obese obstetric patients.
The Role of Echocardiography in Amniotic Fluid Embolism: A Case Series and Review of the Literature
Authors: Simard C. , Yang S. , Koolian M. , Shear R. , Rudski L. , Lipes J. 
Published: September 2022

(Can J Anesth/J Can Anesth. 2021;68:1541–1548)
Amniotic fluid embolism (AFE) is not completely understood and can be difficult to diagnose, as it shares characteristics with other obstetric complications. AFE occurs during labor or soon after delivery and is characterized by acute hypotension, hypoxia, and coagulopathy. The Clark diagnostic criteria for diagnosis of AFE is as follows: sudden cardiorespiratory arrest or both hypotension and respiratory compromise; disseminated intravascular coagulation; clinical onset during labor or within 30 minutes of delivery of the placenta; and absence of fever. Situations that may lead to the exchange of maternal and fetal fluid, such as cesarean delivery or cervical trauma, have been reported as risk factors. Point-of-care echocardiography has recently been used to diagnose and manage maternal shock. This report details three cases of AFE that utilized point-of-care echocardiography.
Indocyanine Green Fluorescence-Guided Surgery for Gastrointestinal Tumors: A Systematic Review
Authors: Sposito Carlo , Maspero Marianna , Belotti Paolo , Simonotti Nicolò , Altomare Michele , Ciana Paolo , Mazzaferro Vincenzo 
Published: September 2022

Objective:
To conduct a systematic review of the currently available literature on the use of ICG to guide surgical dissection in gastrointestinal (GI) cancer surgery.

Background:
Real-time indocyanine green (ICG) fluorescence-guided surgery has the potential to enhance surgical outcomes by increasing patient-tailored oncological precision.

Methods:
MEDLINE, PubMed, EMBASE, and Google Scholar were searched for publications on the use of ICG as a contrast agent in GI cancer surgery until December 2020. Perfusion studies were excluded. Quality of the studies was assessed with the Methodological Index for nonrandomized Studies or Jadad scale for randomized controlled trials. A narrative synthesis of the results was provided, with descriptive statistics when appropriate.

Results:
Seventy-eight studies were included. ICG was used for primary tumor and metastases localization, for sentinel lymph node detection, and for lymph flow mapping. The detection rate for primary colorectal and gastric tumors was 100% after preoperative ICG endoscopic injection. For liver lesions, the detection rate after intravenous ICG infusion was 80% and up to 100% for lesions less than 8 mm from the liver surface. The detection rate for sentinel lymph nodes was 89.8% for esophageal, 98.6% for gastric, 87.4% for colorectal, and 83.3% for anal tumors, respectively. In comparative studies, ICG significantly increases the quality of D2 lymphadenectomy in oncological gastrectomy.

Conclusion:
The use of ICG as a guiding tool for dissection in GI surgery is promising. Further evidence from high-quality studies on larger sample sizes is needed to assess whether ICG-guided surgery may become standard of care.
TREATMENT OF PERSISTENT MACULAR HOLES WITH HEAVY SILICONE OIL
Authors: Lohmann Tibor , Schwarzer Hendrik , Koutsonas Antonis , Djalali-Talab Yassin , Fuest Matthias , Widder Randolf A. , Walter Peter , Roessler Gernot 
Published: September 2022

Background/Purpose:
To determine anatomical success and best-corrected visual acuity after secondary surgery with heavy silicone oil tamponade in patients with persistent full-thickness macular holes.

Methods:
In this retrospective study, 63 eyes with persistent full-thickness macular holes after primary pars plana vitrectomy and internal limiting membrane peeling underwent secondary surgery with heavy silicone oil tamponade. Macular spectral domain optical coherence tomography and best-corrected visual acuity measurements were performed during the follow-up.

Results:
Fifty of 63 eyes (79.4%) achieved anatomical success. In eyes achieving anatomical success, best-corrected visual acuity before primary vitreoretinal surgery was significantly better (0.77 [∼20/125 Snellen] ± 0.24 [1.3–0.3] logarithm of the minimum angle of resolution) compared with eyes not achieving anatomical success (0.88 [∼20/160 Snellen] ± 0.17 [1.1–0.6] logarithm of the minimum angle of resolution, P = 0.044). Minimum linear diameter of full-thickness macular holes was significantly smaller in eyes achieving anatomical success, both before primary (403.4 ± 128.7 [199.0–707.0] µm vs. 568.1 ± 209.1 [307.0–953.0] µm, P = 0.009) and secondary surgery (464.1 ± 215.0 [178.0–1,521.0] µm vs. 663.3 ± 228.5 [451.0–1,301.0] µm, P = 0.010). Patients remaining phakic during all three surgeries did not benefit from best-corrected visual acuity improvement, although anatomical success was achieved.

Conclusion:
Heavy silicone oil tamponade in secondary surgery for persistent full-thickness macular holes is a safe and efficient surgical method. Best-corrected visual acuity and minimum linear diameter before surgery may be indicators for anatomical success.
Unilateral Diffuse Uveal Melanocytic Proliferation (DUMP): Case Report and Brief Review
Authors: Cord Medina Flávio Mac , Reis Raphael Araujo , da Cunha Gomes Pereira Manoella , Gameiro Filho Aluisio Rosa 
Published: September 2022

Abstract

Purpose:
To report a case of unilateral diffuse uveal proliferation (DUMP), in a patient with history of breast cancer, with bone and hepatic metastasis.

Methods:
Case report with funduscopic examination, fundus autofluorescence and spectral domain optical coherence tomography

Results:
A 57-year-old female patient attended at our clinic for a routine glaucoma follow up. Fundoscopy was normal on the right eye, and showed multiple red patches, in the posterior pole and inferior arcade. Multimodal examination was performed, compatible to diffuse uveal melanocytic proliferation on her left eye, and excluding other conditions, such as choroidal metastasis.

Conclusion:
Diffuse uveal melanocytic proliferation is a rare paraneoplastic condition, which usually is presented bilaterally. Unilateral cases of DUMP have been previously described only 5 times on the literature, and are usually associated with breast cancer.
Long-term follow-up of PRPH2-associated retinal dystrophy
Authors: Zhao Zhanlin , Miere Alexandra , Mai LE Hoang , Souied Eric H 
Published: September 2022

Abstract:

Purpose:
To report a thirteen-year follow-up of PRPH2-associated retinal dystrophy.

Methods:
A 54-year-old female patient presented with decreased vision and mild metamorphopsia in both eyes since the age of 40. A complete evaluation was performed using multimodal imaging techniques.

Results:
At presentation, fundus examination revealed multiple irregular pisciform flecks in the posterior pole sparing the peripapillary area in both eyes, as well as some mildly atrophic zones in the perifoveal area. The mildly atrophic areas evolved and merged into a central atrophic zone in the following ten years, leading to a decreased vision of less than 20/400 in both eyes. The genetic molecular diagnosis revealed a mutation in PRPH2/RDS gene (NM_000322.4:c.421T>C (p.Tyr141His)). Based on genetics, imaging, and clinical findings, a diagnosis of multifocal pattern dystrophy simulating STGD1/fundus flavimaculatus (MPDSFF) was evoked. Her mother was found to have the same gene mutation, with multiple irregular pisciform flecks in the posterior pole associated with central areolar choroidal dystrophy.

Conclusions:
This report demonstrated the thirteen-year progression of MPDSFF in a patient with a pathogenic variant of the PRPH2/RDS gene (NM_000322.4:c.421T>C (p.Tyr141His)).
Factors affecting the quality of life of family caregivers of patients with heart failure: A cross-sectional study
Authors: Kim Kyoung-A , Park Jin-Sun , Seo Kyoung-Woo , Choi Eui-Young , Ahn Jeong-Ah 
Published: September 2022

Heart failure is a chronic disease requiring lifetime self-management at home by patients, who often require additional support. However, the long-term nature of this self-management presents great challenges for both heart failure patients and their family caregivers. The role of family caregivers is critical, but little is known about the relationship between the burden, stress, depressive symptoms, and quality of life in the family caregivers of heart failure patients. We aimed to explore caregiver burden, stress, depressive symptoms, and quality of life in both patients with heart failure and their family caregivers and identify the factors associated with family caregivers’ quality of life.
The sample included 120 participants (60 heart failure patients and 60 corresponding family caregivers) from cardiovascular outpatient clinics at 2 university-affiliated hospitals in South Korea from September 2018 to July 2019. The mean ages of the heart failure patients and their caregivers were 72.72 (SD = 12.73) and 57.03 (SD = 13.42) years, respectively. Caregiver burden (r = −0.601, P < .001) and caregiver depressive symptoms (r = -0.535, P < .001) were negatively correlated with the caregivers’ quality of life. The result of the hierarchical multiple regression analysis identified 3 significant factors related to the family caregivers’ quality of life: caregiver’s age (β = −0.257, P = .012), caregiver burden (β = −0.408, P = .002) and caregiver depressive symptoms (β = −0.298, P = .018), with overall explanatory power of 47.5%.
It is necessary to develop practical strategies to improve family caregivers’ quality of life by alleviating their burden and depressive symptoms. Healthcare providers should be engaged with not only heart failure patients but also their family caregivers during the disease management process to improve patients’ outcomes.
HIV incidence among men who have sex with men (MSM) in Metro Manila, the Philippines: A prospective cohort study 2014–2018
Authors: Ditangco Rossana , Mationg Mary Lorraine 
Published: September 2022

The human immunodeficiency virus (HIV) epidemic in the Philippines has been driven by sexual transmission among men who have sex with men (MSM) over the past 2 decades. As the incidence of HIV infection among MSM has not been extensively evaluated, this study aimed to determine the incidence of HIV infections and the associated risk factors among MSM in Metro Manila, Philippines.
This prospective cohort study was conducted in 2 community centers in Metro Manila, the Philippines, between March 2014 and December 2018. MSM who had anal or oral sex in the past 12 months, aged ≥18 years, and confirmed HIV-negative status were enrolled. Participants were followed up every 3 months with repeat HIV testing and assessment of HIV-related practices.
Of the 708 MSM included in this study, a total of 59 HIV seroconversions occurred during the follow-up, resulting in an incidence of 2.7 (95% confidence interval: 2.1–3.5) per 100 patient-years. Multivariate risk regression analysis indicated that age (P = .002) and anal sex with a consensual male partner in the past 3 months (P = .039) were significantly associated with HIV infection.
Our study has shown high rates of incident HIV infection among Filipino MSM. This demonstrates the need for effective HIV prevention, surveillance, treatment, and intervention strategies targeting this population.
A jejunal gastrointestinal stromal tumor with massive gastrointestinal hemorrhage treated by emergency surgery: A case report
Authors: Jabłońska Beata , Szmigiel Paweł , Wosiewicz Piotr , Baron Jan , Szczęsny-Karczewska Weronika , Mrowiec Sławomir 
Published: September 2022

Background:
A jejunal gastrointestinal stromal tumor (GIST) is a rare neoplasm of the gastrointestinal (GI) tract. Massive bleeding due to a jejunal GIST is a diagnostic and therapeutic challenge. It may be a life-threatening GIST complication that requires urgent intervention. Acute GI bleeding, which requires urgent surgical intervention, is a very rare clinical manifestation of GIST. A jejunal GIST with massive hemorrhage with coronavirus disease 2019 in a male patient in older age with many comorbidities has been not reported in the worldwide literature.

Methods:
In this case report, we present an 80-year-old man who was admitted to surgery due to abdominal pain, melena, and hematochezia for several hours. An upper endoscopy and colonoscopy were inconclusive. A multidetector contrast-enhanced computed tomography (CT) of the abdominal and pelvic cavity showed concentric irregular thickening in the distal jejunum.
The histopathological finding showed a GIST measuring 6 cm with a mitotic index 2/50 high power fields. The patient’s hemodynamic condition deteriorated despite initial conservative treatment including a blood transfusion. Therefore, patient underwent the emergency surgery 24 hours after admission: partial jejunal resection with the tumor followed by primary end-to-end anastomosis.

Results:
The mass was removed completely. There were no surgical complications in the postoperative course. On the first postoperative day, a severe acute respiratory syndrome coronavirus 2 polymerase chain reaction test was performed due to a persistent dry cough, which yielded a positive result. After 14 days, the patient died due to pneumonia and circulatory failure.

Conclusions:
This case indicates that jejunal GIST can present as massive lower gastrointestinal bleeding and urgent surgery can successfully stop bleeding and save the patient’s life. The CT scan was the most effective investigation to find the source of GI bleeding in this case. Therefore, we suggest performing CT in patients with acute massive lower gastrointestinal bleeding when the source of bleeding is not visible on endoscopy, and urgent surgical jejunal resection to stop life-threatening bleeding caused by a jejunal GIST.
CD20-positive subcutaneous panniculitis-like T-cell lymphoma presenting as polycranial neuropathy: A CARE-compliant case report and literature review
Authors: Xu Jing , Li Jia , Sun Ya-juan , Quan Wei , Liu Li , Zhang Qing-hui , Qin Yi-dan , Pei Xiao-chen , Su Hang , Chen Jia-Jun 
Published: September 2022

Background:
Subcutaneous panniculitis-like T-cell lymphoma(SPTCL) is a very rare cytotoxic T-cell skin lymphoma involving subcutaneous tissue, and mainly affects young females. T-cell phenotype is characterized by CD3+, CD8+, and CD4−. SPTCT with polycranial neuropathy has rarely been described. SPTCL is believed to show an indolent clinical course unless patients develop haemophagocytic syndrome or sudden respiratory failure. Its treatment has not been established yet.

Case presentation:
We report a case of intractable SPTCT in a 66-year-old woman with multiple cranial nerve palsies and diabetes. She showed involvement of the bilateral facial nerve, left trigeminal nerve, left auditory nerve, and right oculomotor nerve. The single inconspicuous skin lesion in the trunk presented with an erythematous nodule with a diameter of <5 cm and a slightly pink infiltrated plaque. Electromyography revealed bilateral damage to the facial nerve. Differential immunohistochemical characteristics were observed. Immunohistochemistry demonstrated diffuse CD20 positivity. Cerebral spinal fluid analysis revealed elevated protein levels of 0.92 (0.15–0.45) g/L. Her condition regressed severely over time. She was treated with chemotherapy but died 10 months later, the probable cause of death was lung involvement.

Conclusion:
The patient’s involvement with the central nervous system may be associated with positivity for CD20. Molecular biomarkers may act as therapeutic targets for SPTCL.