bluuebunny/crossref_metadata_2025_split huggingface dataset:
INSIGHT FROM RECRUITING DYADS OF INDIVIDUALS WITH DEMENTIA AND CARE PARTNERS FOR A MULTI-SITE ORAL CARE INTERVENTION
Authors: Wang Jing , Siamdoust Shahrzad , Xu Sophie Zhijing , Anderson Ruth , Plassman Brenda , Bailey Donald , Wu Bei 
Published: January 2025

Abstract
Maintaining oral health is essential for individuals with dementia, yet they often need support. We sought to identify lessons learned during the recruitment process for an intervention designed to teach care partners skills to guide individuals with mild dementia in proper oral hygiene techniques and provide reminders to practice oral hygiene care. Throughout the study, research team members from two research sites met regularly to discuss their experiences in recruiting participants. Notes from these meetings served as the basis for identifying key challenges and effective strategies. Recruitment involved direct patient engagement, collaboration with dementia research centers and community organizations, and the use of electronic health record systems, including MyChart. Recruitment coordinators connected study personnel with organizations and support groups, thereby broadening the recruitment base. The most effective strategies were leveraging established relationships or building new ones with clinical dementia experts to access a clinically well-characterized patient pool and presenting at support groups within dementia-focused community organizations to build connections and disseminate information about the study. Barriers to recruitment included the reduced frequency of patient visits to clinics during the COVID-19 pandemic, which limited in-person recruitment opportunities, as well as the time required to establish new relationships with non-affiliated hospitals and community organizations. Facilitating factors included building trust-based relationships with medical and community facilities, diversifying recruitment channels, maintaining flexible and clear communication, and customizing strategies for different contexts. In conclusion, successful recruitment for this intervention required a multifaceted approach that combined strong partnerships with flexibility and tailored communication strategies.
THE ROLE OF TELEHEALTH PAYMENT PARITY ON RECOMMENDED CARE AMONG WORKERS WITH HIGH-RISK FACTORS OF DEMENTIA
Authors: Zhang Zhang 
Published: January 2025

Abstract

Objective
This study examines the impact of telehealth payment parity, requiring equal payment rate for telehealth and in-person services, on the use of recommended care services and emergency department (E.D.) visits among insured workers with high-risk factors of dementia.

Methods
We conducted a causal inference design and adopted a two-way fixed-effect difference-in-differences approach using the Merative Commercial Claims and Encounters database from 2019 to 2021. We focused on insured workers with mental health disorders or cardiometabolic risks (CMRs), which are high-risk factors for dementia.

Results
Telehealth payment parity significantly increased psychotherapy visits by 0.2208 visits per quarter and tele-psychotherapy by 0.4107 visits per quarter. Additionally, it reduced E.D. visits among those with mental health disorders by 0.003 visits per quarter, a 25% relative decrease. However, the policy did not significantly enhance the uptake of preventive care counseling for CMRs.

Conclusion
Telehealth payment parity effectively boosted psychotherapy usage and reduced E.D. visits for mental health disorders. Public health Implications: Future policies and public health interventions should optimize the telehealth payment model to enhance preventive care uptake, especially for those with CMRs.
AGE DIFFERENCES IN PRO-ENVIRONMENTAL BEHAVIORS: IS IT ABOUT ME OR THE NEXT GENERATION?
Authors: Lin Zhixuan , Fung Helene Hoi-Lam 
Published: January 2025

Abstract
Aging society and climate change have emerged as two pressing concerns in modern society. However, questions remain unsolved regarding whether older and younger adults engage in pro-environmental behavior with different frequencies and/or out of different motivations. In the current study, we examined age differences in pro-environmental behaviors, as well as two underlying motivations: self-relevance and self-transcendence motivations. The former is defined as the extent to which people feel personally harmed or worried by climate change (i.e., ecological risk perceptions), and the latter is defined as the extent to which people hold concerns about the next generation. According to the positivity effect in the aging process and the socioemotional selectivity theory, older age could be correlated with lower risk perceptions and higher generativity concerns. These factors indicate opposing directions in age-related differences in pro-environmental behaviors. We conducted a survey among 126 older adults (Mean age = 70.65, SD = 5.12, 61.5% females) and 117 younger adults (Mean age = 25.43, SD = 5.93, 67.2% females). The results revealed that older adults engaged in pro-environmental behaviors more frequently and scored higher on social generativity concerns compared to younger adults. However, no significant age difference was found in ecological risk perceptions. Moreover, social generativity concerns positively correlated with pro-environmental behaviors only among younger adults, but not among older adults. Ecological risk perceptions positively correlated with pro-environmental behaviors among both younger and older adults. These results provide insights into different approaches for encouraging pro-environmental behaviors among younger and older adults.
APP ENGAGEMENT IN TECHNOLOGY-SUPPORTED SPEECH-LANGUAGE THERAPY FOR PRIMARY PROGRESSIVE APHASIA
Authors: Fegter Ollie , Rademaker Alfred , Bona Matthew , Roberts Angela , Rogalski Emily 
Published: January 2025

Abstract
As the global population ages, dementia prevalence is increasing. Primary Progressive Aphasia (PPA) is a clinical dementia syndrome characterized by progressive language decline. Access to care for individuals living with PPA is limited by a shortage of qualified clinicians and evidence-based interventions. While technology-supported interventions have the potential to overcome this barrier, there has been no systematic exploration of factors affecting web application use in this population. This study aimed to evaluate feasibility and acceptability and identify clinical and demographic factors affecting app usage in individuals with PPA. Web application data were analyzed from participants (N=95) of Communication Bridge-2, an NIH stage 2 randomized controlled trial of speech-language therapy for PPA (NCT03371706). Participants were encouraged to complete app-based practice exercises five days per week over the 12-month intervention. Data-driven user-type clustering determined engagement groups based on number of logins. Multinomial logistic regression identified demographic and clinical factors that differed between groups. On average, participants completed 13.7 (SD = 5.95) home practice exercises 3.99 days per week (SD = 1.19) and logged into the app 5.88 times per week (SD = 1.29). Older age and increased education significantly predicted increased app engagement (p &lt;.05), even when accounting for work status; other clinical and demographic factors were nonsignificant. All participants logged into and completed practices exercises on the app at least weekly, demonstrating high feasibility and acceptability. These findings suggest that technology-supported interventions may be a valuable tool to improve access to evidence-based care to individuals with PPA and related conditions.
EVALUATION OF A NURSE PRACTITIONER-LED VIRTUAL BEHAVIORAL MEDICINE PROGRAM: INNOVATIVE NEUROPSYCHIATRIC CARE
Authors: Vellani Shirin , Haslam Lynn , Luke Miles , Singh Amaya , Iaboni Andrea 
Published: January 2025

Abstract
People living with dementia in long-term care (LTC) who exhibit severe neuropsychiatric symptoms are often at risk of being transferred to the hospital from their familiar environment. The virtual Behavioral Medicine (VBM) model was designed to manage these symptoms with intensive virtual support within LTC to prevent hospitalization. We adapted this model to a nurse practitioner (NP)-led approach and conducted a program evaluation to assess its implementation and preliminary effectiveness during its first year. Between April 2023 to March 2024, 102 patients were referred for management of severe neuropsychiatric symptoms and/or consideration for admission to our psychogeriatric unit. The average wait time from referral to the first consultation was 10 days, with follow-ups occurring every 7.6 days by an NP and every 16.2 days involving a geriatric psychiatrist. The average length of stay in the program was 41 days. The average Neuropsychiatric Inventory score improved from 31 to 9.4 at discharge, and the number of medications decreased from 16 to 9. Among the 102 patients, 48 (47%) improved with VBM alone, avoiding hospital admission. In a survey of 60 LTC teams, 49 (81%) responded. Over 90% noted improvement in neuropsychiatric symptoms and expressed satisfaction with the quality of care and support provided by the VBM team. All respondents felt heard and more equipped to care for residents in-house, though some reported challenges with the virtual technology. These first-year insights into operations will inform continuous quality improvement. Further evaluation of caregiver satisfaction and the effectiveness of the NP-led model is warranted.
NEXT STEPS: ADVANCING CLINICAL TRIALS RESEARCH IN NURSING HOMES
Authors: Unroe Kathleen , Hickman Susan , Levy Cari , Zimmerman Sheryl , Floyd Alex , Saliba Debra 
Published: January 2025

Abstract
The National Institute on Aging recently funded the $15.6 million NEXT STEPs (Nursing home EXplanatory clinical Trials: Supporting Transformation by Enhancing Partnerships) initiative to create the organizational structure, processes, and procedures to develop a sustainable, diverse network of nursing home (NH) partners and researchers conducting clinical trials to guide optimal care. The perspectives and participation of interdisciplinary clinical providers and researchers are critical to inform the launch and activities of this innovative network. In addition to leveraging existing infrastructure and collaborations, NEXT STEPs embraces a comprehensive perspective of NH research that addresses six key elements of successful trials: 1) Designing the intervention, including anticipation of the study’s potential burden on NH staff and residents, and potential regulatory issues; 2) Ensuring equity throughout the trial’s design, conduct, analyses and dissemination; 3) Recruiting both NHs and individual participants, such as assessing and communicating the value of a given intervention to residents, providers, staff or leadership; 4) Cultivating engagement throughout the project, including plans to monitor and respond to internal or external events that affect projects; 5) Assessing outcomes, including identifying metrics and reliable data sources that can be used across projects; and 6) Following up and following through on communicating results and developing sustainable paths to implement successful interventions. Activities of this project will be guided through deep involvement with partner workgroups. This presentation will describe the evidence that supported the key elements and highlight the opportunities available for researchers, providers, and advocates to participate in the NEXT STEPS initiative.
TRAJECTORIES OF FALLS AND ASSOCIATED FACTORS AMONG ADULTS 65 AND OLDER: INSIGHTS FROM THE HEALTH AND RETIREMENT STUDY
Authors: Balasundaram Rohit Baal , Krenek-Schneider Brittany , Mendoza Edna Patricia , Patel Anup Dharmendrakumar , Quach Lien , Nguyen Uyen-Sa 
Published: January 2025

Abstract
Falls are the leading cause of injuries among older adults in the United States, with over 14 million older adults, or 1 in 4, reporting a fall each year. This longitudinal prospective cohort study investigated fall trajectories and associated risk factors in people with no prior history of falls. We analyzed 2006 to 2018 data from the Health and Retirement Study (HRS), restricted to participants 65+ who did not report falls prior to the baseline year of 2006. The outcome is biennial incidence of falls, and risk factors include sociodemographic and biological factors, and health behaviors. Group-based trajectory modeling identified distinct fall trajectories. Multinomial logistic regression assessed associations between trajectories and risk factors;. Three distinct trajectories of falls incidence were identified over a 12-year period. Nearly half of the population (48.9%) remained in a low-stable risk group, 22.4% experienced a moderate but steadily increasing risk, and 28.7% belonged to a high-increasing risk group. Individuals identified as Black/African American or “Other” race were associated with a lower likelihood of being in the high-risk group compared to White/Caucasian individuals (OR = 0.38, 95% CI: 0.27, 0.55; OR = 0.32, 95% CI: 0.16, 0.67, respectively). Conversely, having comorbid conditions was associated with a higher likelihood of being in the high-risk group (OR = 1.37, 95% CI: 1.08, 1.73). The study identified distinct trajectories of fall risk among older adults without a history of falls, significantly varying by race/ethnicity and comorbid conditions, highlighting the need for targeted fall prevention strategies tailored to specific groups.
Volumetric (dilatant) plasticity in geodynamic models and implications on thermal dissipation and strain localization
Authors: Momoh Ekeabino , Bhat Harsha S , Tait Stephen , Gerbault Muriel 
Published: January 2025

SUMMARY
Here, we present a new thermomechanical geodynamic, numerical implementation that incorporates Maxwell viscoelastic rheology accounting for temperature-dependent power-law dislocation creep and pressure-sensitive, non-associated Drucker–Prager brittle failure, as well as for volumetric stresses and strains during viscoplastic flow, a departure from the traditional incompressible assumptions. In solving for energy conservation, we incorporate the heat source term resulting from irreversible mechanical deformations, which embodies viscoelastic and viscoplastic work, and by considering the total stress tensor and total inelastic strain rate tensors, including dilatant plasticity effects for lithospheric-scale applications, instead of only the shear terms as is usually assumed for incompressible materials. This form of the work term thus allows to consider, volumetric deformation and to couple the energy equation to the constitutive description, and hence the stress balance, via the evolving temperature field. Code design enables us to switch individual features of this general rheology ‘on or off’ and thus to benchmark this implementation with published numerical experiments of crustal-scale shortening experiments. We investigate whether ‘brittle-plastic’ compressibility can promote or inhibit localization of deformation and thermal evolution during compression for crustal, and upper mantle rheology. For both crustal-scale and lithospheric-scale experiments, we establish that the feedback from volumetric dissipation, while contributing to temperature increase along with shear dissipation, can potentially slow down heat production per unit time, depending on the choice of boundary conditions. Our new implementation can be used to address buckling problems and collision tectonics.
Effects of maternal Cu, Mn, and Zn supplementation from different sources on physiological and productive responses of cows and their offspring
Authors: Cruz Vinicius Alves , Marques Rodrigo S , Kvamme Keenan , Limede Arnaldo Cintra , Cidrini Fernando Alerrandro Andrade , Cidrini Iorrano Andrade , dos Santos Nascimento Keuven , Mackey Shea J , Cooke Reinaldo F , Farmer Chance , Heldt Jeff 
Published: January 2025

Abstract
Seventy-two nonlactating, pregnant Angus cows (initial body weight [BW] = 637 ± 13 kg; body condition score [BCS] = 5.5 ± 0.07 yr; and age = 6.1 ± 0.57; exposed to artificial insemination = 54 and bull = 18) were ranked by pregnancy type, BW, and BCS and assigned to receive a supplement containing: 1) Cu, Mn, and Zn sulfate source (INR; n = 24), 2) Cu, Mn, and Zn organic-complexed source (ORG; n = 24), or 3) Cu, Mn, and Zn hydroxychloride source (HDX; n = 24). From day 11 (days of gestation 195 ± 5.1) to calving, cows were allocated to rangeland pasture. From day 0 until calving, cows were gathered and fed the treatments thrice a week. Cow BW and BCS were recorded, and blood was collected on days 11 and 10, upon calving, and at weaning. Liver biopsies were performed in all cows on day 10 and upon calving (cows and calves). Longissimus muscle (LM) biopsies were performed, and blood was collected in all calves upon calving. Calves were weaned on day 260, backgrounded for 99 d, and then sent to a commercial feedyard. Calves blood samples were collected on days 245, 260, 264, 268, 275, 280, and 288. No differences were detected (P ≥ 0.31) for cow BW and BCS changes among treatments during gestation, and mineral sources did not improve (P ≥ 0.16) mineral liver concentrations of Zn, Mn, Se, and Co at parturition. However, there was a tendency (P = 0.07) for HDX to have improved liver Cu concentration vs. ORG and INR cows. Cows fed HDX and ORG had improved (P ≤ 0.03) BCS at weaning, and BCS changed from parturition to weaning vs. INR cows. No treatment differences were detected (P ≥ 0.21) for calf birth measurements, IgG levels, mRNA expression of hepatic enzymes, or LM genes associated with muscle and adipose tissue development. At weaning and during the backgrounding, no treatment differences were detected (P ≥ 0.21) for offspring performance, health outcomes, plasma cortisol, serum nonesterified fatty acids, and serum β-hydroxybutyrate. However, a tendency for a treatment × day interaction was detected (P = 0.07) for haptoglobin concentrations, which was reduced (P &lt; 0.01) in calves from cows supplemented with HDX vs. calves from cows supplemented with ORG and INR 15 d after weaning. No treatment effects were noted (P ≥ 0.35) for final BW, feedyard average daily gain, and carcass traits between treatment groups. Overall, different sources of Cu, Mn, and Zn supplemented to late-gestating beef cows yielded similar cow-calf productive responses from birth to finishing.
The First Spin-Orbit Obliquity of an M dwarf/brown dwarf system: an eccentric and aligned TOI-2119 b
Authors: Doyle Lauren , Cañas Caleb I , Libby-Roberts Jessica E , Cegla Heather M , Stefánsson Guðmundur K , Anderson David , Armstrong David J , Bender Chad , Bayliss Daniel , Carmichael Theron W , Casewell Sarah , Kanodia Shubham , Lafarga Marina , Lin Andrea S J , Mahadevan Suvrath , Monson Andy , Robertson Paul , Veras Dimitri 
Published: January 2025

ABSTRACT
We report the first instance of an M dwarf/brown dwarf obliquity measurement for the TOI-2119 system using the Rossiter–McLaughlin effect. TOI-2119 b is a transiting brown dwarf orbiting a young, active early M dwarf ($T_{\rm {eff}}$ = 3553 K). It has a mass of 64.4 M$_{\rm {J}}$ and radius of 1.08 R$_{\rm {J}}$, with an eccentric orbit (e = 0.3) at a period of 7.2 d. For this analysis, we utilize NEID spectroscopic transit observations and ground-based simultaneous transit photometry from the Astrophysical Research Consortium and the Las Campanas Remote Observatory. We fit all available data of TOI-2119 b to refine the brown dwarf parameters and update the ephemeris. The classical Rossiter–McLaughlin technique yields a projected star–planet obliquity of $\lambda =-0.8\pm 1.1^\circ$ and a three-dimensional obliquity of $\psi =15.7\pm 5.5^\circ$. Additionally, we spatially resolve the stellar surface of TOI-2119 utilizing the Reloaded Rossiter–McLaughlin technique to determine the projected star–planet obliquity as $\lambda =1.26 \pm 1.3^{\circ }$. Both of these results agree within $2\sigma$ and confirm the system is aligned, where TOI-2119 b joins an emerging group of aligned brown dwarf obliquities. We also probe stellar surface activity on the surface of TOI-2119 in the form of centre-to-limb variations as well as the potential for differential rotation. Overall, we find tentative evidence for centre-to-limb variations on the star but do not detect evidence of differential rotation.
Episodic slow breathing in mice markedly reduces fear responses
Authors: de Sousa Abreu Raquel P. , Hoffman Ann N. , Bondarenko Evgeny , Huang Yuqing , Burgos Pujols Rosanna E. , Fanselow Michael S. , Feldman Jack L. 
Published: January 2025

AbstractWe sought to delineate neural mechanisms underlying the effects of controlled breathing in humans, such as in meditation or breathwork, which can reduce depression, anxiety, stress, and pain. Thus, we developed a murine model, where breathing frequency in awake mice can be substantially slowed. When done for 30 min/day for 4 weeks, these mice had significant reductions in stress-related changes in behavior compared to control mice. We conclude that slow breathing effects on emotional state are present in mice, and which cannot be attributed directly to top-down influences such as volitional or emotional control or placebo effects. Our study paves the way for investigations of the neural mechanisms underlying body-brain interactions related to the effects of controlled breathing as well as a platform for optimization of its therapeutic use for amelioration of ordinary and pathological stress and anxiety in humans.
TGFβ1 and RGD Cooperatively Regulate SMAD 2/3 Mediated Oncogenic Effects in Prostate Cancer Cells in Bioorthogonally Constructed Hydrogels
Authors: Pol Mugdha , Gao Hanyuan , Fox Joseph M , Jia Xinqiao 
Published: January 2025

ABSTRACTTo recapitulate prostate cancer metastasis, DU145 cells were cultured in a hyaluronic acid-based, bioorthogonally constructed, protease-degradable hydrogel. In the presence of covalently conjugated integrin-binding peptide (GRGDSP), DU145 cells formed tumoroids and exhibited small protrusions. Upon addition of soluble transforming growth factor beta 1 (TGFβ1), cells underwent morphological changes to form extended interconnected cellular networks. Contrarily, in RGD-free hydrogels, cells maintained spherical structures even in the presence of TGFβ1. In RGD-conjugated hydrogels, TGFβ1 induced nuclear localization of SMAD2/3, upregulating a wide range of TGFβ1 target genes and proteins. Prolonged exposure to TGFβ1 led to matrix remodeling and induced epithelial-to-mesenchymal transition in DU145 cells, with loss of epithelial markers and gain of mesenchymal markers. TGFβRI/ALK5 inhibitor SB-431542 attenuated TGFβ1-induced morphological changes, abrogated nuclear localization of SMAD2/3, and restored the expression of key epithelial markers. Our findings highlight the cooperative role of TGFβ1 signaling and integrin binding peptide in the acquisition of aggressive phenotype and promoting tumor progression.TEASERPhysiologically relevant 3D cell culture platforms enabled mechanistic investigation of growth factor signaling related to prostate cancer metastasis.