bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of durable chemoimmunotherapy response via circulating tumor DNA in advanced esophageal squamous cell carcinoma
Authors: Yang Dongyang , Xu Fei , Li Ying , Lai Xiaorong , Xian Bohong , Yu Pengli , Chen Rongrong , Li Zijun , Ma Dong 
Published: August 2022

AbstractImmune checkpoint inhibitor (ICI)‐based therapies have shown promising advances for the first‐line treatment of advanced or metastatic esophageal cancer (EC). However, few studies concerning the identification of patients who achieve durable response from ICIs have been previously reported. In the present study, pre‐ and on‐treatment plasma circulating tumor DNA (ctDNA) were analyzed in 10 patients with advanced esophageal squamous cell cancer (ESCC) receiving first‐line chemoimmunotherapy. Patients with decreased molecular tumor burden index (mTBI) >7% experienced longer progression‐free survival (PFS) and durable clinical benefit (DCB, PFS ≥ 6 months). In addition, five patients showed stable disease at first scan, all three patients with decreased mTBI > 7% achieved DCB, while two cases with decreased mTBI ≤ 7% experienced non‐DCB. Our results demonstrate that ctDNA monitor might help identify which ESCC patients respond to chemoimmunotherapy.
Umbrella review of nursing interventions NIC for the treatment and prevention of suicidal behavior
Authors: Sufrate‐Sorzano Teresa , Pérez Jesús , Juárez‐Vela Raúl , Garrote‐Cámara MaríaElena , de Viñaspre Regina Ruiz , Molina‐Luque Fidel , Santolalla‐Arnedo Iván 
Published: August 2022

AbstractPurposeThe aim of this umbrella review was to determine the most effective nursing interventions for the prevention and management of suicidal behavior. In order to do so, the review identifies interventions from the Nursing Interventions Classifications taxonomy with evidence to this end.MethodsA systematic search was conducted for systematic reviews included in the PubMed, CINAHL, Cochrane, Scopus, Web of Knowledge, and Joanna Briggs Institute databases between January 1, 2011 and May 1, 2020.FindingsThe review is made up of 21 systematic reviews. In order to carefully analyze the interventions described, these were coded into categories, grouping the interventions into those based on psychological therapy, interventions related to pharmacotherapy, interventions related to the professional relationship between health professional and patient, and interventions aimed at the general public.ConclusionsNursing interventions for suicide risk management are prevalent in the scientific literature and are shown to be effective for patients with suicidal ideation or suicide attempts. Prevention and treatment of suicidal behavior require the provision of coping tools, behavioral interventions that directly address suicidal thoughts and behaviors, and support through therapeutic partnerships, among others.Implications for nursing practiceThis paper synthesizes the most current evidence on the most effective Nursing Interventions Classifications interventions for the treatment and prevention of suicidal behavior. It provides nursing practitioners with a comprehensive review of the therapeutic interventions with the best evidence and is useful for the development of clinical guidelines and protocols, as well as for the development of health policies and plans.
Patchiness of aquatic plant assemblages in seasonal wetlands: Local abiotic factors explain the spatial distribution of growth forms
Authors: Matias Lígia Queiroz , Santos Larissa Ibiapina , Romero Ricardo Espíndola , Menezes Bruno Sousa 
Published: August 2022

AbstractThe spatial distribution of aquatic plants can be influenced by dispersal capacity, and local abiotic factors. In general, aquatic plants are widely distributed and have a large‐scale ability to disperse. However, some groups have narrower tolerance and are more sensitive to local environmental variations. Thus, we investigated which factors explain the spatial distribution of growth forms in different seasonal pools in the Brazilian semi‐arid region. We hypothesized that if dispersal limitation is absent and pools have similar abiotic conditions, all pools must have communities with the same growth form pattern that fit together in the water column. Conversely, if the abiotic factors among pools differ significantly, there will be a higher frequency of certain growth forms associated with the most striking local factors. We found no relationship between growth form composition in pools and geographic distance (rM = −0.004; P = 0.96), indicating high dispersal capacity. Nonetheless, the pool showed different growth forms proportions, indicating that different abiotic factors affect each local. Additionally, the variation explained by the abiotic factors was higher than the distance. Nitrate, ammonia, cation exchange capacity and redox potential were the main environmental variables related to the presence of growth forms. Helophytes and bottom‐rooted emergent hydrophytes were positively associated with nitrate and redox potential, whereas bottom‐rooted submerged hydrophytes were positively associated with ammonia. Unpredictably, free‐floating emergent hydrophytes were more frequent in pools with high cation exchange capacity. This association may come from a nutrient flux integrated system between soil and water. Our results suggest that the effect of abiotic factors is stronger than dispersal limitation on the growth forms composition in Brazilian semi‐arid pools, and the frequency of growth forms in each pool depends on the role most striking (or joint) of the local limnological and edaphic variables.
The quality effects of agency staffing in residential aged care
Authors: Ma Nelson , Sutton Nicole , Yang Jin Sug , Rawlings‐Way Olivia , Brown David , McAllister Gillian , Parker Deborah , Lewis Rachael 
Published: August 2022

AbstractObjectivesIn Australia, temporary agency workers are a relatively small but enduring component of the residential aged care workforce. However, evidence from other countries suggests reliance on agency workers has a detrimental effect on the quality of care (QoC). We examined whether QoC outcomes differ for Australian residential aged care facilities (RACFs) based on their reliance on agency care staff.MethodsA retrospective observational study was conducted using de‐identified datasets obtained under the legal authority of the Royal Commission into Aged Care Quality and Safety. Regression analysis was conducted using data comprising 6221 RACF‐year observations, across 5 years (2015–2019), from 1709 unique RACFs in Australia.ResultsAfter controlling for other determinants of QoC, RACFs with a greater reliance on agency care staff have poorer QoC outcomes, with significantly higher rates of complaints, missing persons, reportable assaults, hospitalisations, and accreditation flags.ConclusionsConsistent with international evidence, we found that the QoC of Australian RACFs is sensitive to the reliance on agency staff in delivering direct care to residents. These findings illustrate the importance of workers' employment conditions, alongside other workforce characteristics, in driving the quality of residential aged care.
Editorial: switching to tenofovir alafenamide monotherapy is effective and safe for other nucleos(t)ide analogues‐treated patients with chronic hepatitis B
Authors: Wang Meng‐Lan , Chen En‐Qiang 
Published: August 2022

LINKED CONTENTThis article is linked to Ogawa et al papers. To view these articles, visit https://doi.org/10.1111/apt.17107 and https://doi.org/10.1111/apt.17173
Editorial: investigating the association between sweetened beverages and risk of inflammatory bowel disease—authors' reply
Authors: Fu Tian , Wang Xiaoyan , Chen Jie 
Published: August 2022

LINKED CONTENTThis article is linked to Fu et al papers. To view these articles, visit https://doi.org/10.1111/apt.17149 and https://doi.org/10.1111/apt.17178
A crossover study evaluating the sex‐dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects
Authors: Hijma Hemme , Koopmans Ingrid , Klaassen Erica , Doll Robert Jan , Zuiker Rob , Groeneveld Geert Jan 
Published: August 2022

AimWe assessed whether total sleep deprivation (TSD) in combination with pain tests yields a reliable method to assess altered pain thresholds, which subsequently may be used to investigate (novel) analgesics in healthy subjects.MethodsThis was a two‐part randomized crossover study in 24 healthy men and 24 women. Subjects were randomized 1:1 to first complete a day of nonsleep‐deprived nociceptive threshold testing, followed directly by a TSD night and morning of sleep‐deprived testing, or first complete the TSD night and morning sleep‐deprived testing, returning 7 days later for a day of nonsleep‐deprived testing. A validated pain test battery (heat, pressure, electrical burst and stair, cold pressor pain test and conditioned pain modulation [CPM] paradigm) and sleep questionnaires were performed.ResultsSubjects were significantly sleepier after TSD as measured using sleepiness questionnaires. Cold pressor pain tolerance (PTT, estimate of difference [ED] −10.8%, 95% CI −17.5 to −3.6%), CPM PTT (ED −0.69 mA, 95% CI −1.36 to −0.03 mA), pressure PTT (ED −11.2%, 95% CI −17.5% to −4.3%) and heat pain detection thresholds (ED ‐0.74 °C, 95% CI −1.34 to −0.14 °C) were significantly decreased after TSD compared to the baseline morning assessment in the combined analysis (men + women). Heat hyperalgesia was primarily driven by an effect of TSD in men, whereas cold and pressure hyperalgesia was primarily driven by the effects of TSD observed in women.ConclusionsTSD induced sex‐dependent hyperalgesia on cold, heat and pressure pain, and CPM response. These results suggest that the TSD model may be suitable to evaluate (novel) analgesics in early‐phase drug studies.
Recent updates in the development of small molecules as potential clinical candidates for Alzheimer's disease: A review
Authors: Umar Tarana , Meena Rampratap , Mustehasan  , Kumar Pawan , Khan Asim Ali 
Published: August 2022

AbstractAlzheimer's disease (AD) is one of the prominent causes for disability and lowered quality of life worldwide in elderly population. It has fostered immense burden to AD patients, families and society. Burgeoning progress in the field of pathogenesis over last two decades has persuaded the investigation of novel pharmacological therapeutics that focuses towards the pathophysiological events of AD. Miscellaneous clinical trials, development and testing of interventions aimed at various targets, such as anti‐tau and anti‐amyloid interventions, neurotransmitter modification, neuroprotection and anti‐neuroinflammation interventions, cognitive enhancement and interventions to palliate behavioural symptoms have been carried out. Despite massive efforts to find disease‐modifying therapies, there lingers a vital need for continuing the advancement in progress of the AD research. This review features the new developments of small molecule compounds that will be beneficial in evolution of new AD therapies. In particular, this review briefly describes summary of mechanistic causes chiefly associated with AD and focuses on medicinal approach via small molecule inhibitors that can manage cognitive impairment and dysfunction and may combat Alzheimer's development.
Early pandemic impacts on family environments that shape childhood development and health: A Canadian study
Authors: McIsaac Jessie‐Lee D. , Lamptey De‐Lawrence , Harley Jane , MacQuarrie Madison , Cummings Randi , Rossiter Melissa D. , Janus Magdalena , Turner Joan 
Published: August 2022

AbstractObjectivesChanges to income and employment are key social determinants of health that have impacted many families during the COVID‐19 pandemic. This research aimed to understand how changes to employment and income influenced family environments that contribute to early childhood development and health.MethodsA concurrent triangulation mixed method design was used through a cross‐sectional survey on early impacts of the COVID‐19 pandemic involving families with young children in the Canadian Maritime provinces (n = 2158). Analyses included multivariate regression models to examine whether changes to employment and income predicted changes to Family access to resources and social support, parenting Abilities and self‐care at home, and home Routines and Environments (FARE Change Scale). Content analysis was used to identify themes from the open‐ended questions.ResultsChanges to employment and income early in the pandemic like no longer working but continued to receive salary, working fewer hours for the same salary earned before the pandemic, no longer working nor receiving salary, working fewer hours resulting in salary reduction, essential worker status and household income were significant predictors of FARE Change Scale when ethnicity/cultural background and province of residence are controlled (P < .05). Themes provided a description of family impacts, including shifting employment and income, finding time and capacity, feelings of guilt and the creation of new routines.ConclusionOur study provides insight on the implications of public health restrictions, such as the importance of increased time for parents (through reduced work hours) and access to resources and social support to support child development and health.
Approach to the patient with a variant of uncertain significance on genetic testing
Authors: Newey Paul J 
Published: August 2022

AbstractEstablishing a genetic diagnosis may lead to major health benefits for the patient and their wider family, but is dependent on the accurate interpretation of test results. The processes of variant interpretation are by their nature imprecise such that the potential for uncertain test results (i.e., variant(s) of uncertain significance [VUS]) are an inevitable consequence of genomic testing. With an increased responsibility for diagnostic testing in the hands of the specialty physician (e.g., endocrinologist) rather than clinical geneticist, it is essential that they are familiar with the possible outcomes of testing including an understanding of the VUS category. While uncertainty is endemic to many aspects of clinical medicine, receiving a VUS result may pose a considerable challenge to both the clinician and the patient. In this article, a framework to support decision‐making when confronted with a VUS variant is provided, focusing on the key components of the genetic testing pathway. This highlights the importance of assessing the VUS result in the context of the clinical presentation and genetic testing strategy, the value of multidisciplinary team working and ensuring good communication with the patient.
Psychiatric genetic counseling for people with copy number variants associated with psychiatric conditions
Authors: Morris Emily , Inglis Angela , Austin Jehannine 
Published: August 2022

Abstract22q11.2 deletion is one of the most well‐known copy number variants (CNVs) associated with developing a psychiatric condition (e.g., schizophrenia), but there is a growing list of other CNVs which also confer substantial risk for developing psychiatric conditions. With increased use of chromosome microarray and exome sequencing, the frequency with which these CNVs are detected is increasing. While individuals with such CNVs often receive genetic counseling, research shows that associated psychiatric conditions are less often addressed—clinicians tend to focus on the nonpsychiatric manifestations of the CNV. This represents an important service gap for people with these CNVs and their families, as research shows that not only do these families want genetic counseling about psychiatric illness, it can also produce meaningful positive outcomes for people, including increases in empowerment, and self‐efficacy. Therefore, there is a need to ensure that individuals with psychiatric condition‐associated CNVs are being counseled about these manifestations of their condition in a way that can promote the best outcomes. In this paper we describe the process of providing genetic counseling in two clinical scenarios in which a psychiatric susceptibility CNV is identified: (1) in an individual who has not been diagnosed with a psychiatric condition and (2) in an individual with an established psychiatric condition.
Epidemiology and aetiology of chronic rhinosinusitis in Asia—A narrative review
Authors: Chee Jeremy , Pang Khang Wen , Low Terese , Wang De Yun , Subramaniam Somasundaram 
Published: August 2022

AbstractBackgroundDespite having a similar prevalence to Western populations, literature on chronic rhinosinusitis (CRS) in the Asian population is sparse. There is limited data on the epidemiology and aetiology of CRS in Asia.ObjectivesTo review the current literature on the epidemiology and aetiology of CRS in Asia.MethodsThis is a narrative review of published data on the epidemiology and aetiology of CRS. Studies on CRS in Asian countries, published in English and indexed on PubMed or Google Scholar were reviewed. Where available, data extracted included epidemiology, endotype and cytokine profiles and genetic profiles.Results and ConclusionThe prevalence of CRS in Asia ranges widely from 2.1% to 28.4%. Type 2 inflammation has been reported in 5%–55% of Asian patients, with lower levels of Type 2 cytokines reported in head to head comparisons of Western versus Asian patients. Notably, there exists marked heterogeneity in criterion of the tissue eosinophilic infiltration for diagnosis of type 2 CRS. Our review suggests that differences in prevalence of CRS and proportion of eosinophilic CRS between Asia and Europe and the Americas requires further study. Large‐scale Asian studies utilising standardised definitions are needed to bridge this gap. Head to head genetic and microbiomal analysis may also be useful in understanding differences in CRS between the Asian and Western populations.
Randomized controlled trial comparing conventional and traction endoscopic submucosal dissection for early colon tumor (CONNECT‐C trial)
Authors: Ichijima Ryoji , Ikehara Hisatomo , Sumida Yorinobu , Inada Taisuke , Nemoto Daiki , Nakajima Yuki , Minagawa Takeyoshi , Sumiyoshi Tetsuya , Inoki Kazuya , Yoshida Naohisa , Inoue Ken , Fukuzawa Masakatsu , Minoda Yosuke , Tsutsumi Koshiro , Esaki Mitsuru , Gotoda Takuji 
Published: August 2022

ObjectivesEndoscopic submucosal dissection (ESD) is a widely used treatment for early gastrointestinal cancer. However, colon ESD remains challenging. Previous studies on colon ESD using the traction method used a small sample, single‐center design, providing insufficient evidence of this procedure's efficacy. We thus aimed to investigate the efficacy and safety of the traction method in colon ESD in this multicenter randomized trial.MethodsWe conducted a prospective, multicenter, randomized, two‐arm controlled trial at 10 facilities in Japan. A 1:1 allocation was conducted for the conventional ESD (C‐ESD) and traction ESD (T‐ESD) groups. The primary end‐point was ESD procedure time.ResultsWe included 128 C‐ESD and 123 T‐ESD cases from April 2020 to August 2021. The median procedure times for C‐ESD and T‐ESD were 61 (40–100) and 53 (40–76) min (P = 0.18), respectively, and no significant differences were observed between the groups. Subgroup analysis showed that the median procedure times for patients with a lesion diameter of ≥30 mm in the C‐ESD and T‐ESD groups were 89 (57−80) and 69 (50−104) min (P = 0.05), respectively, and for nonexpert operators were 81 (62−120) and 64 (52−109) min (P = 0.07), respectively.ConclusionsThe traction method did not contribute to a significantly shortened ESD procedure time. However, this method may be useful when the tumor diameter is large or if the procedure is conducted by nonexpert endoscopists.
Activated factor XI is associated with increased factor VIIa – Antithrombin complexes in stable coronary artery disease: Impact on cardiovascular outcomes
Authors: Paszek Elżbieta , Pociask Elżbieta , Ząbczyk Michał , Butenas Saulius , Undas Anetta 
Published: August 2022

AbstractBackgroundCoronary artery disease (CAD) is associated with a prothrombotic tendency including increased factor (F) VIIa‐antithrombin (FVIIa‐AT) complexes, a measure of tissue factor (TF) exposure, and activated FXI (FXIa). We investigated whether increased FVIIa–AT complexes are associated with FXIa and active TF and if major adverse clinical outcomes are predicted by the complexes in CAD.MethodsIn 120 CAD patients, we assessed FVIIa–AT complex concentrations and the presence of circulating FXIa and active TF. Levels of 8‐iso‐prostaglandin F2α (8‐iso‐PGF2α), interleukin‐6, high‐sensitivity C reactive protein, prothrombin fragment 1 + 2, and free Tissue Factor Pathway Inhibitor were determined. Myocardial infarction (MI), ischemic stroke, systemic thromboembolism (SE), and cardiovascular (CV) death were recorded separately and as a composite endpoint, during follow‐up.ResultsFVIIa–AT complexes were positively associated with current smoking and multivessel CAD. Elevated FVIIa–AT complexes characterized patients with circulating FXIa and/or active TF in association with increased plasma isoprostanes but not with thrombin generation or inflammatory markers. During a median follow‐up of 106 months (interquartile range 95–119), high baseline levels of FVIIa–AT complexes predicted ischemic stroke/SE (HR 4.61 [95% CI 1.48–18.42]) and a composite endpoint of MI, stroke/SE, and CV death (HR 7.47 [95% CI 2.81–19.87]).ConclusionsThis study is the first to show that high FVIIa–AT complexes characterize advanced CAD patients with detectable FXIa and active TF, which is, in part, driven by oxidative stress. High FVIIa–AT complexes were associated with the risk of ischemic stroke/SE during long‐term follow‐up, highlighting the need for effective antithrombotic agents in CAD.
Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis
Authors: Mariajoseph Frederick P. , Chen Zhibin , Sekhar Praba , Rewell Sarah S. , O'Brien Terence J. , Antonic‐Baker Ana , Semple Bridgette D. 
Published: August 2022

AbstractPosttraumatic epilepsy (PTE) is a well‐known chronic complication following traumatic brain injury (TBI). Despite some evidence that age at the time of injury may influence the likelihood of PTE, the incidence of PTE in pediatric populations remains unclear. We therefore conducted a systematic review to determine the overall reported incidence of PTE, and explore potential risk factors associated with PTE after pediatric TBI. A comprehensive literature search of the PubMed, Embase, and Web of Science databases was conducted, including randomized controlled trials and cohort studies assessing the incidence of PTE in TBI pediatric patients. We excluded studies with a sample size of <10 patients and those in which a pediatric cohort was not clearly discernable. The review was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) guidelines. We found that the overall incidence of PTE following pediatric TBI was 10% (95% confidence interval [CI] = 5.9%–15%). Subgroup analysis of a small number of studies demonstrated that the occurrence of early seizures (cumulative incidence ratio [CIR] = 7.28, 95% CI = 1.09–48.4, p = .040), severe TBI (CIR = 1.81, 95% CI = 1.23–2.67, p < .001), and intracranial hemorrhage (CIR = 1.60, 95% CI = 1.06–2.40, p = .024) increased the risk of PTE in this population. Other factors, including male sex and neurosurgical intervention, were nonsignificantly associated with a higher incidence of PTE. In conclusion, PTE is a significant chronic complication following childhood TBI, similar to in the adult population. Further standardized investigation into clinical risk factors and management guidelines is warranted. PROSPERO ID# CRD42021245802.