bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurologic Complications in Hereditary Hemorrhagic Telangiectasia with Pulmonary Arteriovenous Malformations: A Systematic Review
Authors: Agarwal Joel , LaBranche Jennifer , Dhillon Simran , Allison W. Ted , Jeerakathil Thomas , Vethanayagam Dilini 
Published: June 2022

ABSTRACT:Background:Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant multi-organ condition occurring with a 1 in 3800 prevalence in Alberta. This genetic disorder leads to vascular malformations in different organs including the lungs and brain, commonly affecting pulmonary vasculature leading to pulmonary arteriovenous malformations (PAVMs). PAVMs lead to right-to-left shunts, which may be associated with neurologic complications. We aimed to evaluate and summarize the reported neurologic manifestations of individuals with HHT with pre-existing PAVMs.Methods:We performed a qualitative systematic review to determine available literature on neurological complications among patients with PAVMs and HHT. Published studies included observational studies, case studies, prospective studies, and cohort studies including search terms HHT, PAVMs, and various neurologic complications using MEDLINE and EMBASE.Results:A total of 449 manuscripts were extracted including some duplicates of titles, abstracts, and text which were screened. Following this, 23 publications were identified for inclusion in the analysis. Most were case reports (n = 15). PAVMs were addressed in all these articles in association with various neurological conditions ranging from cerebral abscess, ischemic stroke, hemorrhagic stroke, embolic stroke, and migraines.Conclusion:Although HHT patients with PAVMs are at risk for a variety of neurological complications compared to those without PAVMs, the quality and volume of evidence characterizing this association is low. Individuals with PAVMs have a high prevalence of neurological manifestations such as cerebral abscess, transient ischemic attack, cerebral embolism, hemorrhage, and stroke. Mitigating stroke risk by implementing proper standardized screening techniques for PAVMs is invaluable in preventing increased mortality.
Engraving Portraits in the Skin: Vernacular Commemorative Tattoos for Ceauşescu, Tito, and Stalin
Authors: Asavei Maria Alina 
Published: June 2022

AbstractThis article focuses on the privately created commemorative practice of getting the official portraits of three former socialist leaders as a tattoo: Nicolae Ceauşescu, Josip Broz Tito, and Josif Vissarionovich Dzhugashvili (Stalin). The mnemonic actors who have indulged in this practice after the 1990s contribute to a culture informed by vernacular memorials that conform to neither the official politics of remembrance and its aesthetics nor its content. Correspondingly, this article focuses on the aesthetic, political, and epistemic intricacies of remembering through the inked body. Unlike memorial tattoos that mark the recognition of a group that has suffered the same trauma, the commemorative tattoos analyzed in this article reflect a centrifugal set of identity concerns, ranging fromYugonostalgiato individualized spaces of self-healing and identity affirmation. The argument put forth is that tattoos can act as vernacular commemorations collected into a body archive of nostalgia for the ontological security of the past and “great leadership.” Thus, the overarching question is not how and why people materialize memories through their bodies but rather to what ends the inked body accommodates commemorative representations of former political leaders who are usually depicted in public memory as “unworthy” of commemoration.
BOG PINE AND DECIDUOUS TREES CHRONOLOGIES RELATED TO PEAT SEQUENCES STRATIGRAPHY OF THE PODEMSZCZYZNA PEATLAND (SANDOMIERZ BASIN, SOUTHEASTERN POLAND)
Authors: Margielewski Włodzimierz , Krąpiec Marek , Buczek Krzysztof , Korzeń Katarzyna , Szychowska-Krąpiec Elżbieta , Pociecha Agnieszka , Pilch Jolanta , Obidowicz Andrzej , Sala Dariusz , Klimek Agnieszka 
Published: June 2022

ABSTRACTThe Podemszczyzna peatland (Sandomierz Basin, SE Poland) is a place of peat exploitation for balneological purposes. The thickness of organic sediments (minerogenic peat) reaches 4.0 m, while the beginning of peat accumulation was dated using the radiocarbon method (14C) at 13,517–13,156 cal BP. During the peat exploitation numerous fragments of subfossil wood (of various species) were excavated and, based on dendrochronological analyzes and 14C dating (wiggle-matching), two short floating chronologies were elaborated: bog pine chronology (147 years long) and deciduous trees (oak, elm) chronology (139 years long). 14C dating has shown that the bog pine chronology (ca. 9980–9830 mod. cal BP) is the oldest pine chronology found in the Polish peatlands so far. It was synchronous with the Preboreal decline of fluvial activity and peat formation, whereas dying off of trees was connected with distinct rise of fluvial activity. Floating chronology of deciduous trees is much younger and encompasses time interval of ca. 680–545 cal BP. The trees’ encroachment on the peatland was related to the terrestrialization of the depositional fen, recorded in the loss on ignition curve in the form of mineral sediment delivery to the bog, as well as it is marked in the pollen record.
Class and relative wealth accumulation in five European countries: Sociological Lessons from the Household Financial and Consumption Survey (European Central Bank, 2014 Wave)
Authors: Duvoux Nicolas , Papuchon Adrien 
Published: June 2022

AbstractRecent sociological research tends to move beyond the divide between economics and sociology in the study of socioeconomic inequality. It focuses primarily on the relationship between social class and work-related income. Yet, it has been shown that wealth, rather than income, was the decisive feature of contemporary inequality and that wealth and income increasingly tend to be captured through the same households. To bridge the gap between the two disciplines and provide a comprehensive understanding of socioeconomic inequality, this article developed an integrated analysis of wealth and income distribution among occupational groups at different ages in five major European countries. To that end, we used the Household Financial and Consumption Survey [2014 wave] of the European Central Bank network.
The facade of power and the power of the facade: memory and meaning in Victorian cities
Authors: Rodger Richard 
Published: June 2022

AbstractTerraces and tenements provide the facades upon which are inscribed texts and decorative images. Embedded in the walls, these ‘plaques’ convey meanings and memories that saturate the built environment with references to the past. Evidence based on property surveys, maps and archival documents form the empirical basis from which it is concluded that images and inscriptions presented a wider geo-political and historical awareness in the everyday setting of local residents.
Searching for Transient Slow Slips Along the San Andreas Fault Near Parkfield Using Independent Component Analysis
Authors: Michel Sylvain , Jolivet Romain , Lengliné Olivier , Gualandi Adriano , Larochelle Stacy , Gardonio Blandine 
Published: June 2022

AbstractThe Parkfield segment of the San Andreas Fault (SAF) sits at the transition between the locked Cholame segment to the South and the SAF creeping segment to the North. The Parkfield segment hosts regular 6 earthquakes followed by postseismic deformation. Recent studies based on geodetic data have highlighted spatial and temporal variations of aseismic slip rate in addition to postseismic slip along this section of the fault. We combine Global Navigation Satellite Systems (GNSS) and seismicity data over the 2006–2018 period to detail a comprehensive picture of transient slip events. We produce a catalog of relocated seismicity and repeating earthquakes. We use a variational Bayesian independent component analysis decomposition on GNSS data to separate geodetic deformation due to non‐tectonic sources from signals of potential tectonic origin. We then reconstruct the temporal evolution of fault slip and detect potential slip transients. Those events, determined as mostly aseismic with the exception of one related to a 4.8 earthquake, occur more frequently during the 2004 6 post‐seismic period than during the subsequent inter‐seismic phase. Our study illustrates the rich dynamics of seismic and aseismic slip during both post‐ and inter‐seismic periods along active faults.
Microphysical Characteristics of Raindrop Size Distribution and Implications for Radar Rainfall Estimation Over the Northeastern Tibetan Plateau
Authors: Li Qiong , Wei Jiahua , Yin Jianguo , Qiao Zhen , Cao Jiongwei , shi Yang 
Published: June 2022

AbstractRaindrop size distribution (DSD) observations with OTT PARSIVEL2 disdrometers at Dari and Delingha in the northeast of the Tibetan Plateau (TP) during summer 2019 and 2020 were utilized to investigate the DSD characteristics and DSD‐based polarimetric radar quantitative precipitation estimation (QPE) relations on the X, Ku, and Ka bands. The DSD characteristics were examined for different rain rates (R) and for stratiform and convective rainfall types. The raindrop spectra became wider and flatter as the R increased. Gamma parameters N0, μ, and λ (representing intercept, shape, and slope parameters, respectively) were smaller for convective compared to stratiform rainfall, corresponding to the broader and flatter convective raindrop spectra. The μ–λ and Dm–log10Nw relationships were also examined in our study. There was a significant μ–λ correlation, with a quadratic function relationship. The summer convective rainfall at both Dari and Delingha showed continental‐like clusters based on the Dm–log10Nw relationship. The DSD‐based two‐parameter polarimetric radar QPE relations (R(Zh, ZDR), R(KDP, ZDR)), and one‐parameter relations (R(Zh), R(KDP)) at the X, Ku, and Ka bands were proposed, and the R computed from DSD was implemented to evaluate these relations. The performance of two‐parameter models was stronger than that of one‐parameter models. Moreover, R(Zh, ZDR) and R(KDP, ZDR) performed better for the X and Ku bands, while the R(KDP, ZDR) model performed best for the Ka band. The ground‐based Ka/Ku band measurement Z at Dari was used to evaluate the Z–R and R−Dm QPE relations. The R−Dm relations had a better performance compared to the Z–R relations. The Ku radar‐derived R series are more consistent with the DSD measured counterparts. The research of the dual‐polarization radar parameter models is vital to develop radar QPE algorithms on the TP.
A Simulation Study on the Variation of Thermospheric O/N2 With Solar Activity
Authors: Li Zhongli , Luan Xiaoli , Lei Jiuhou , Ren Dexin 
Published: June 2022

AbstractThe ratio of number density of atomic oxygen (O) to that of molecular nitrogen (N2) in the thermosphere (O/N2) on the constant pressure surface, which has complex temporal and spatial characteristics, is widely regarded as an important parameter connecting the terrestrial thermosphere and daytime ionosphere. Previous studies demonstrated that the thermospheric O/N2 increases with increasing solar activity, and the changes in O/N2 with solar activity show significant difference between winter and summer hemispheres. However, the root causes, which are responsible for the solar activity variation of O/N2, are not fully understood. In this study, the contributions of various physical and chemical processes on the response of O/N2 to the solar radiation change were quantitatively investigated through a series of controlled simulations from the Thermosphere Ionosphere Electrodynamics General Circulation Model. The simulation results suggested that the chemical processes lead to the increase of thermospheric O/N2 over the globe with increasing solar activity. The increase of O/N2 with solar activity is dominated by the enrichment of O abundance and the loss of N2 abundance in the lower and upper thermosphere, respectively. Moreover, the simulation results suggested that the stronger hemispheric asymmetry is attributed to the stronger thermospheric circulation, which changes the vertical advection of O/N2 through both direct and indirect effects.
CDiP technology for reverse engineering of sporadic Alzheimer’s disease
Authors: Kondo Takayuki , Yada Yuichiro , Ikeuchi Takeshi , Inoue Haruhisa 
Published: June 2022

AbstractAlzheimer’s disease (AD) is a neurodegenerative disease that causes cognitive impairment for which neither treatable nor preventable approaches have been confirmed. Although genetic factors are considered to contribute to sporadic AD, for the majority of AD patients, the exact causes of AD aren’t fully understood. For AD genetics, we developed cellular dissection of polygenicity (CDiP) technology to identify the smallest unit of AD, i.e., genetic factors at a cellular level. By CDiP, we found potential therapeutic targets, a rare variant for disease stratification, and polygenes to predict real-world AD by using the real-world data of AD cohort studies (Alzheimer’s Disease Neuroimaging Initiative: ADNI and Japanese Alzheimer’s Disease Neuroimaging Initiative: J-ADNI). In this review, we describe the components and results of CDiP in AD, induced pluripotent stem cell (iPSC) cohort, a cell genome-wide association study (cell GWAS), and machine learning. And finally, we discuss the future perspectives of CDiP technology for reverse engineering of sporadic AD toward AD eradication.
“Clean” doping to advance 2D material phototransistors
Authors: Wang Zhen , Wang Peng , Hu Weida 
Published: June 2022

AbstractDoping is an essential element to develop next-generation electronic and optoelectronic devices and has to break the limit of specific steps during material synthesis and device fabrication. Here the authors reveal “clean” doping to enhance the electric and photoelectric performance of two-dimensional (2D) indium selenide (InSe) via a neutron-transmutation method for the first time, even after device fabrication.
Giant excitonic upconverted emission from two-dimensional semiconductor in doubly resonant plasmonic nanocavity
Authors: Qi Pengfei , Dai Yuchen , Luo Yang , Tao Guangyi , Zheng Liheng , Liu Donglin , Zhang Tianhao , Zhou Jiadong , Shen Bo , Lin Feng , Liu Zheng , Fang Zheyu 
Published: June 2022

AbstractPhonon-assisted upconverted emission is the heart of energy harvesting, bioimaging, optical cryptography, and optical refrigeration. It has been demonstrated that emerging two-dimensional (2D) semiconductors can provide an excellent platform for efficient phonon-assisted upconversion due to the enhanced optical transition strength and phonon-exciton interaction of 2D excitons. However, there is little research on the further enhancement of excitonic upconverted emission in 2D semiconductors. Here, we report the enhanced multiphoton upconverted emission of 2D excitons in doubly resonant plasmonic nanocavities. Owing to the enhanced light collection, enhanced excitation rate, and quantum efficiency enhancement arising from the Purcell effect, an upconverted emission amplification of >1000-fold and a decrease of 2~3 orders of magnitude in the saturated excitation power are achieved. These findings pave the way for the development of excitonic upconversion lasing, nanoscopic thermometry, and sensing, revealing the possibility of optical refrigeration in future 2D electronic or excitonic devices.
Distinct promoter regions of the oxytocin receptor gene are hypomethylated in Prader-Willi syndrome and in Prader-Willi syndrome associated psychosis
Authors: Heseding Hannah M. , Jahn Kirsten , Eberlein Christian K. , Wieting Jelte , Maier Hannah B. , Proskynitopoulos Phileas J. , Glahn Alexander , Bleich Stefan , Frieling Helge , Deest Maximilian 
Published: June 2022

AbstractPrader-Willi syndrome (PWS) is a rare neurodevelopmental disorder caused by a loss of usually paternally expressed, maternally imprinted genes located on chromosome 15q11-q13. Individuals with PWS display a specific behavioral phenotype and have a higher susceptibility than the general population for certain psychiatric conditions, especially psychosis. An impairment of the oxytocin system has been described in Prader-Willi syndrome, but has not yet been investigated in detail on the epigenetic level. Recent studies have pointed out altered methylation patterns of the oxytocin receptor gene (OXTR) in various psychiatric disorders, including psychosis. In this study, we investigated methylation rates of CpG dinucleotides in the promoter region of the oxytocin receptor gene via bisulfite-sequencing using DNA extracted from peripheral blood samples of 31 individuals with PWS and 14 controls matched for age, sex, and BMI. Individuals with PWS show significantly lower methylation in the intron 1 region of the OXTR than neurotypical controls (p = 0.012). Furthermore, male PWS subjects with psychosis show significantly lower methylation of the OXTR exon 1 region than those without psychosis (p = 0.002). Transcription factor binding site analysis revealed E2F1 as a transcription factor potentially binding to the exon 1 region. E2F1 is physiologically regulated by Necdin, an anti-apoptotic protein whose corresponding gene is located within the PWS locus. This study provides evidence of a disruption of the Oxytocin system on an epigenetic level in PWS in general and in individuals with PWS and psychosis.
The role of the anterior temporal cortex in action: evidence from fMRI multivariate searchlight analysis during real object grasping
Authors: Knights Ethan , Smith Fraser W. , Rossit Stéphanie 
Published: June 2022

AbstractIntelligent manipulation of handheld tools marks a major discontinuity between humans and our closest ancestors. Here we identified neural representations about how tools are typically manipulated within left anterior temporal cortex, by shifting a searchlight classifier through whole-brain real action fMRI data when participants grasped 3D-printed tools in ways considered typical for use (i.e., by their handle). These neural representations were automatically evocated as task performance did not require semantic processing. In fact, findings from a behavioural motion-capture experiment confirmed that actions with tools (relative to non-tool) incurred additional processing costs, as would be suspected if semantic areas are being automatically engaged. These results substantiate theories of semantic cognition that claim the anterior temporal cortex combines sensorimotor and semantic content for advanced behaviours like tool manipulation.
A photosynthetic rate prediction model using improved RBF neural network
Authors: Pu Liuru , Li Yuanfang , Gao Pan , Zhang Haihui , Hu Jin 
Published: June 2022

AbstractA photosynthetic prediction rate model is a theoretical basis for light environmental regulation, and the existing photosynthetic rate prediction models are limited by low modeling speed and prediction accuracy. Therefore, this paper analyses effects of light quality on photosynthesis rate, and proposes a method based on Radial basis function (RBF) optimized by Quantum genetic algorithm (QGA) to establish photosynthetic rate prediction model. We selected "golden embryo2 formula 98-1F1" cucumber seedlings as experimental material and used LI-6800 to record the photosynthetic rates under different temperatures, light intensities and light quality. Experimental data is used to train and test the proposed model. The determinant coefficient of the model between the predicted and the measured values is 0.996, the straight slope of linear fitting is 1.000, and the straight intercept of linear fitting is 0.061. Moreover, the proposed method is compared with 6 artificial intelligence algorithms. The comparison results also validate that the proposed model has the highest accuracy compared with other algorithms.
Deciphering waste bound nitrogen by employing psychrophillic Aporrectodea caliginosa and priming of coprolites by associated heterotrophic nitrifiers under high altitude Himalayas
Authors: Sheikh Tahir , Baba Zahoor , Yatoo Ali Mohd , Hamid Basharat , Iqbal Sadaf , Wani Fehim , Fatima Sabah , Alfarraj Saleh , Javed Ansari Mohammad 
Published: June 2022

AbstractHimalayan ecosystem is characterized by its fragile climate with rich repositories of biodiversity. Waste collection and disposal are becoming increasingly difficult due to topographical variations.Aporrectodea caligenosa, a versatile psychrophillic soil dweller, is a useful biocatalyst with potent bio-augmented capability for waste treatment at low temperatures. Microcosm experiments were conducted to elucidate the comprehensive nature of biogenic nitrogen transformation to NH4+and NO3−produced by coupling of earthworm-microbes. Higher biogenic recovery of NH4+-N from coprolites of garden soil (47.73 ± 1.16%) and Himalayan goat manure (86.32 ± 0.92%) with an increment of 14.12 and 47.21% respectively over their respective control (without earthworms) with a linear decline beyond 4th week of incubation was reported. NO3–-N recovery progressively sustained in garden soil and goat manure coprolites during entire incubation with highest 81.81 ± 0.45 and 87.20 ± 1.08 µg-N g−1dry weight recorded in 6th and 5th week of incubation respectively and peak increments as 38.58 and 53.71% relative to respective control (without earthworms). Declined NH4+–N in coprolites at low temperature (15.0 ± 2.0 °C) evidenced increased nitrification rates by taking over the process by abundant nitrifying microbes. Steady de-nitrification with progressive incubation on an average was 16.95 ± 0.46 ng-N g−1per week and 21.08 ± 0.87 ng-N g−1per week compared to 14.03 ± 0.58 ng-N g−1per week and 4.50 ± 0.31 ng-N g−1per week in respective control treatments. Simultaneous heterotrophic nitrification and aerobic denitrification (SHNAD) was found to be a prominent bioprocess at low temperature that resulted in high and stable total nitrogen and nitrate accumulation from garden soil and goat manure with relative recovery efficiency of 11.12%, 14.97% and 14.20%; 19.34%.A. caligenosashows promising prospects for mass applicability in biogenic N removal from manure of Himalayan goat.
“Long COVID” results after hospitalization for SARS-CoV-2 infection
Authors: Rigoni Marta , Torri Emanuele , Nollo Giandomenico , Donne Livia Delle , Rizzardo Sebastiano , Lenzi Lorenza , Falzone Andrea , Cozzio Susanna 
Published: June 2022

AbstractLong-term sequelae of symptomatic infection caused by SARS-CoV-2 are largely undiscovered. We performed a prospective cohort study on consecutively hospitalized Sars-CoV-2 patients (March–May 2020) for evaluating COVID-19 outcomes at 6 and 12 months. After hospital discharge, patients were addressed to two follow-up pathways based on respiratory support needed during hospitalization. Outcomes were assessed by telephone consultation or ambulatory visit. Among 471 patients, 80.9% received no respiratory support during hospitalization; 19.1% received non-invasive ventilation (NIV) or invasive mechanical ventilation (IMV). 58 patients died during hospitalization, therefore 413 were enrolled for follow-up. At 6 months, among 355 patients, the 30.3% had any symptoms, 18.0% dyspnea, 6.2% neurological symptoms. Fifty-two out of 105 had major damages in interstitial computed tomography images. NIV/IMV patients had higher probability to suffer of symptoms (aOR = 4.00, 95%CI:1.99–8.05), dyspnea (aOR = 2.80, 95%CI:1.28–6.16), neurological symptoms (aOR = 9.72, 95%CI:2.78–34.00). At 12 months, among 344, the 25.3% suffered on any symptoms, 12.2% dyspnea, 10.1% neurological symptoms. Severe interstitial lesions were present in 37 out of 47 investigated patients. NIV/IMV patients in respect to no respiratory support, had higher probability of experiencing symptoms (aOR = 3.66, 95%CI:1.73–7.74), neurological symptoms (aOR = 8.96, 95%CI:3.22–24.90). COVID-19 patients showed prolonged sequelae up to 12 months, highlighting the need of follow-up pathways for post-COVID-19 syndrome.