bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors of recurrent pharyngotonsillitis among preschool children attending a rural family health center, Kafr El-Sheikh Egypt
Authors: Mohamed Fatma Y. , Saied Shimaa M. , Attala Asmaa O. , Atlam Samir Abd Al Majeed 
Published: June 2022

Background
Recurrent pharyngotonsillitis in children poses a global and local public health burden and causes an extra load on families and health systems.

Aim
This study aimed to determine the frequency and some potential risk factors for recurrent pharyngotonsillitis among the preschool children attending Matboul Family Health-Care Center, Kafr El-Sheikh Governorate, Egypt.

Patients and methods
A cross-sectional study was carried out on 360 children, using a predesigned valid interview questionnaire filled by interviewing parents of studied children.

Results
About two-thirds (66.4%) of the participants had recurrent pharyngotonsillitis, regarding seasonal variations of pharyngotonsillitis attack, more than two-thirds of attacks (79.7%) in recurrent cases occurred during winter, while in nonrecurrent cases the majority of cases (86.4%) occurred in autumn; second child or next was more prone to recurrence. There was a significant relationship between recurrent pharyngotonsillitis and some sociodemographic and clinical risk factors as family income, living conditions, passive smoking, bad general hygiene, frequent receiving of antibiotics, comorbidities such as allergy, and a positive family history of recurrence. Clinical severity and course of episodes, history of allergy, family socioeconomics, and handwashing to be significant independent predictors of recurrent pharyngotonsillitis.

Conclusions and recommendations
Recurrent pharyngotonsillitis was prevalent in the studied children; clinical severity and course of episodes, history of allergy, family socioeconomics, and handwashing were found to be significant independent predictors of recurrence of pharyngotonsillitis. Many of recurrence risk factors are preventable. So, health education and socioeconomic promotion should be focused.
Inhibition of miR-182 represses growth of hepatocellular carcinoma cells by targeting SOX11
Authors: Liu Zhi , Chen Jianyu , Mo Lin , Chuan Chuan , Chen Hui , Li Jianshui , Hou Songlin 
Published: June 2022

Purpose: To investigate the effect of microRNA-182 (miR-182) on hepatocellular carcinoma (HCC) and its mechanisms of action.Methods: Sixty-five HCC tissues and matched adjacent tissues were obtained, and miR-182 and sexdetermining region on the Y Chromosome (SRY)-related HMG box 11 (SOX11) expression were quantified using reverse transcription-polymerase chain reaction (RT-PCR). SOX11-positive cells were identified by immunohistochemistry and the correlation between SOX11 and miR-182 expression was analyzed by Spearman correlation analysis. Huh-7 cells were transfected with the miR-182 mimic, the miR-182 inhibitor, and/or si-SOX11, and cell proliferation was measured by cell counting kit-8 (CCK-8) assay. Apoptosis was assessed by flow cytometry. Luciferase reporter assay was used to investigate the putative target gene of miR-182. A xenograft nude mouse model was established by transfection with miR-182 antagomir, while tumor volume and weight were calculated. SOX11, cleaved caspase-3, cleaved poly (ADP ribose) polymerase (PARP), B-cell lymphoma-2 (Bcl-2), and Bcl-2-associated X (Bax) protein levels were analyzed by western blot.Results: MiR-182 expression increased and SOX11 expression was decreased in HCC tissues (p < 0.05). Luciferase reporter assay data confirmed that miR-182 directly targets SOX11. Inhibition of miR-182 repressed proliferation and Bcl-2 expression, but increased protein expression of cleaved caspase-3, cleaved RAPP, and Bax in Huh-7 cells (p < 0.05). In addition, suppression of SOX11 reversed the effects of miR-182 on cell proliferation and apoptosis. The miR-182 antagomir decreased tumor growth and miR-182 expression but increased SOX11 expression in vivo (p < 0.05).Conclusion: MiR-182 and SOX11 may be novel therapeutic targets for HCC patients.
Simulation of training solution for the prevention of medication errors in the emergency ward
Authors: Khari Sorour , Pazokian Marzieh 
Published: June 2022

Objectives: The purpose of the present study was to determine the effect of simulation training on nurses' drug errors in the hospital emergency ward in Iran.
Methods: This quasi-experimental research was conducted over six months. The statistical population, who entered the study through a census, consisted of 52 nurses working in the emergency department of Imam Hossein Hospital. Data collection tools included a demographic questionnaire and Wakefield's drug error questionnaire.
Results: The mean and standard deviation of the difference in medication errors before and after the intervention was 0.31. ± 0.55 for non-injectables and 0.18 ± 0.61 for injectable drugs. A yearly increase in nurse working experience was associated with a decrease in medication errors of -1.73.
Conclusion: The present study results showed that simulation training using clinical scenarios for nurses is an efficacious step to prevent drug errors.
Új szerepben 60 fölött az online térben
Authors: Arató András 
Published: June 2022

Az előadó esettanulmányként saját példáján mutatja be, hogy egy új szerepvállalás milyen pozitív változásokat hozhat egy nyugdíjas korú ember életében.
Az időskori aktivitás az ő esetében családi örökség, édesapja 83 évesen bekövetkezett haláláig folyamatosan dolgozott szaklektorként és fordítóként, nagyapja 82 éves korában megnyert egy pályázatot, amely a korszerű fizikatanítási módszerekről szólt.
Arató András villamosmérnöki munkaköréből történt nyugdíjba vonulása után, 65 éves korában egy véletlennek köszönhetően vált az interneten főleg a fiatalok körében ismertté. Szomorkásan mosolygó fotói alapján elnevezték a fájdalmát elrejtő Hide the pain Haroldnak, és a képeiből elkezdtek vicces mémeket gyártani. Kezdetben nem fogadta el új szerepkörét, megpróbált küzdeni ellene. Több évbe telt, mire rájött, hogy amit nem tud megváltoztatni, annak az élére kell állni. 72 évesen jutott el odáig, hogy létrehozott egy saját internetes oldalt a rajongói számára, és elkezdett azon dolgozni, hogy a kezdetben nem mindig pozitív üzenetet hordozó mémeket egy követhető, pozitív életszemlélet váltsa fel. Az alapgondolat, hogy az élet kisebb-nagyobb kellemetlenségeit nem kell túl komolyan venni, egy bánatos mosollyal túl kell lépni rajtuk, visszhangra talált a fiatalok körében. Követőinek száma világszerte már meghaladja a félmilliót, de legsikeresebb posztjai a megosztások révén tízmilliókhoz jutnak el.
Az így szerzett népszerűség megváltoztatta a mindennapi életét. Meghívások révén Szibériától Dél-Amerikáig eljutott a világ számos országába, korábban inkább introvertált személyisége nyitottabbá vált a közszereplésre. A világ eseményeivel, az újabb technikai lehetőségekkel, a fiatalok gondolkodásmódjával való lépéstartás állandó elfoglaltságot jelent számára. Története egyszeri és megismételhetetlen, de példát mutat arra, hogy egy időskori karrierváltásnak milyen pozitív következményei lehetnek.
Điều trị phẫu thuật lún dương vật bảo tồn bao qui đầu: Báo cáo 433 bệnh nhân
Authors: Bích Trần Ngọc , Sơn Trần Ngọc 
Published: June 2022

Mục tiêu: Đề xuất chỉ định mổ, phân độ lún và kỹ thuật mổ lún dương vật. Đánh giá kết quả điều trị phẫu thuật.
Phương pháp:
- Đối tượng: 433 bệnh nhi bị lún dương vật được điều trị phẫu thuật từ 4/2013 đến 1/2022.
- Phương pháp: mô tả hàng loạt ca bệnh, tiến cứu
Kết quả: 433 bệnh nhân có tuổi trung bình là 6,8 tuổi (1-15). Phân độ lún: lún nặng có 331 bệnh nhân (76,4%), lún trung bình có 68 bệnh nhân (15,7%), lún nhẹ có 34 bệnh nhân(7,8%). Kết quả sớm sau mổ: kết quả tốt là 36,3% (157/433), trung bình là 63,7% (276/433). Kết quả qua theo dõi trung bình 25 tháng ở 312 bệnh nhân: Kết quả tốt là 47,8% (149/312), trung bình là 52,2%(163/312). Kết quả tốt của lún nhẹ là 100% (20/20), của lún trung bình là 79,4% (50/63), của lún nặng là 34,4% (79/229).
Kết luận: Lún dương vật nên được chẩn đoán sớm và xác định mức độ lún để có chỉ định điều trị. Phẫu thuật bảo tồn bao qui đầu cho kết quả thẩm mỹ đẹp.
Development of fruit candies from wood apple (Limonia acidissim) and passion fruit (Passiflora edulis), nutritional and acceptability study during storage
Authors: Urooj​ Asna 
Published: June 2022

OBJECTIVES:Fruit candies were prepared using Wood apple (Limonia acidissima) and Passion fruit (Passiflora edulis) and evaluated for the proximate composition, antioxidant activity, flavonoids and phenolics contents, sensory attributes, storage stability, and microbial load in the developed products. Wood apple and passion fruit are cheaper, highly nutritious and easily perishable, and seasonally available fruits. This study planned to make these fruits available through the year by preserving them as soft candies.
MATERIAL AND METHODS:Soft candies were developed stored and quality parameters were assessed for a period of 90 days. The candies were evaluated by a panel for sensory attributes using 9 point hedonic scale.
RESULTS:The acid content of the preserved products remained the same during the entire storage. The moisture content in both the products was > 12% and the protein content ranged from 1.4% to 2.34%. As expected, the fat and crude fiber contents were low. The total phenolics and flavonoids were present in appreciable amounts. The developed products showed acceptable sensory attributes and were microbiologically safe at the end of the storage period and fit for consumption.
CONCLUSION:Hence the study concluded that, the developed wood apple jam and fruit bar in this study was safe and fit for consumption. The seasonal fruits can be exploited for preparation of fruit candies.
Development and Refinement of the American Occupational Therapy Association’s Knowledge Translation Toolkit
Authors: Juckett Lisa A. , Schmidt Elizabeth K. , Tanner Kelly Jane , Sagester Grace , Wengerd Lauren R. , Hunter Elizabeth G. , Lieberman Deborah , Richardson Hillary 
Published: June 2022

Abstract
Importance: Occupational therapy practitioners are expected to translate promising discoveries from empirical research into routine practice with their clients. However, complex barriers can influence practitioners’ knowledge translation (KT) efforts, leading the American Occupational Therapy Association’s Evidence-Based Practice (EBP) group to develop the KT Toolkit tailored to the perceived needs of occupational therapists and occupational therapy assistants.
Objective: To identify common barriers to implementing EBPs and potential strategies to support EBP uptake.
Design: Cross-sectional survey.
Setting: United States.
Participants: Occupational therapy practitioners.
Outcomes and Measures: Data underwent descriptive and directed content analysis, the latter of which was guided by the Consolidated Framework for Implementation Research.
Results: Occupational therapy survey respondents (N = 818) identified common EBP implementation barriers (e.g., lack of time and resources, difficulty understanding research findings). Initial KT Toolkit content was developed to address these barriers and included resources for searching for, analyzing, and applying evidence in practice.
Conclusions and Relevance: Survey findings have informed the development of the KT Toolkit, which includes resources designed to support occupational therapy practitioners’ EBP implementation efforts. This KT Toolkit is available at AOTA.org and will be continuously revised and updated on an ongoing basis.
What This Article Adds: Several barriers limit the extent to which occupational therapy practitioners can implement evidence with their client populations. The KT Toolkit is directly informed by practitioner input and provides resources to support practitioners in their efforts to translate knowledge into real-world practice.
Feature-tracking cardiac magnetic resonance method: a valuable marker of replacement fibrosis in hypertrophic cardiomyopathy
Authors: Rezaeian Nahid , Hosseini Leila , Omidi Negar , Khaki Mahya , Najafi Homa , Kasani Kianoosh , Mousavizadeh Mostafa , Khalili Yasaman , Komasi Mohammad Mehdi Hemmati , Toloueitabar Yaser , Asadian Sanaz 
Published: June 2022

PurposeLeft ventricular (LV) replacement fibrosis is a marker of adverse cardiac events in hypertrophic cardiomyopathy (HCM). We aimed to assess the efficacy of the feature-tracking cardiac magnetic resonance (FT-CMR) in the detection of LV replacement fibrosis.Material and methodsFifty-one patients with HCM (51% female, mean age = 21 ± 5.2 years) and significant myocardial hypertrophy, who underwent CMR between February 2018 and December 2019 were enrolled. Functional and 3D FT-CMR parameters were measured. LV global longitudinal strain, global radial strain (GRS), and global circumferential strain (GCS) were recorded. The percentage of enhanced myocardial mass was calculated. Univariate and multivariate regression analyses were performed to determine the predictors of fibrosis. A p-value of less than 0.05 was considered significant.ResultsThe mean enhanced mass percentage was 15.2 ± 10.53%. Among LV volumetric parameters, end-systolic and end-diastolic volume indices predicted fibrosis (fitness [F] = 8.11 and p = 0.006 vs. F = 6.6 and p = 0.012, correspondingly). The univariate linear regression demonstrated that GCS and GRS predicted total enhanced mass (%) (F = 12.29 and p = 0.001 vs. F = 7.92 and p = 0.007, respectively). After the inclusion of all volumetric and deformation parameters, the multivariate analysis identified the model of a combination of LV end-diastolic volume index (LV EDVI) and LV GCS as a robust predictor of the fibrosis percentage (F = 8.86 and p = 0.005).ConclusionsNon-contrast CMR parameters including LV GCS and LV EDVI are valuable markers of replacement fibrosis in HCM patients with notable myocardial hypertrophy.
Fire in lichen-rich subarctic tundra changes carbon and nitrogen cycling between ecosystem compartments but has minor effects on stocks
Authors: Heim Ramona J. , Yurtaev Andrey , Bucharova Anna , Heim Wieland , Kutskir Valeriya , Knorr Klaus-Holger , Lampei Christian , Pechkin Alexandr , Schilling Dora , Sulkarnaev Farid , Hölzel Norbert 
Published: June 2022

Abstract. Fires are predicted to increase in Arctic regions due to ongoing climate change. Tundra fires can alter carbon and nutrient cycling and release a substantial quantity of greenhouse gases with global consequences. Yet, the long-term effects of tundra fires on carbon (C) and nitrogen (N) stocks and cycling are still unclear. Here we used a space-for-time approach to investigate the long-term fire effects on C and N stocks and cycling in soil and aboveground living biomass. We collected data from three large fire scars (>44, 28, and 12 years old) and corresponding control areas and used linear mixed-effect models in a Bayesian framework to analyse long-term development of C and N stocks and cycling after fire. We found that tundra fires had no long-term effect on total C and N stocks because a major part of the stocks was located belowground in soils which were largely unaltered by fire. However, fire had a strong long-term effect on stocks in the aboveground vegetation, mainly due to the reduction in the lichen layer. Fire reduced N concentrations in graminoids and herbs on the younger fire scars, which affected respective C/N ratios and may indicate an increased post-fire competition between vascular plants. Aboveground plant biomass was depleted in 13C in all three fire scars. In soil, the relative abundance of 13C changed with time after fire. Our results indicate that in lichen-rich subarctic tundra ecosystems, the contribution of fires to the release of additional carbon to the atmosphere might be relatively small as soil stocks appear to be resilient within the observed time frame.
Modeling interactions between tides, storm surges, and river discharges in the Kapuas River delta
Authors: Sampurno Joko , Vallaeys Valentin , Ardianto Randy , Hanert Emmanuel 
Published: June 2022

Abstract. The Kapuas River delta is a unique estuary system on the western coast of the island of Borneo, Indonesia. Its hydrodynamics are driven by an interplay
between storm surges, tides, and river discharges. These interactions are likely to be exacerbated by global warming, leading to more frequent
compound flooding in the area. The mechanisms driving compound flooding events in the Kapuas River delta remain, however, poorly known. Here we
attempt to fill this gap by assessing the interactions between river discharges, tides, and storm surges and how they can drive a compound
inundation over the riverbanks, particularly within Pontianak, the main city along the Kapuas River. We simulated these interactions using the
multi-scale hydrodynamic model SLIM (Second-generation Louvain-la-Neuve Ice-ocean Model). Our model correctly reproduces the Kapuas River's hydrodynamics and its interactions with tides and storm surge
from the Karimata Strait. We considered several extreme-scenario test cases to evaluate the impact of tide–storm–discharge interactions on the
maximum water level profile from the river mouth to the upstream part of the river. Based on the maximum water level profiles, we divide the Kapuas
River's stream into three zones, i.e., the tidally dominated region (from the river mouth to about 30 km upstream), the transition region
(from about 30 km to about 150 km upstream), and the river-dominated region (beyond 150 km upstream). Thus, the local water
management can define proper mitigation for handling compound flooding hazards along the riverbanks by using this zoning category. The model also
successfully reproduced a compound flooding event in Pontianak, which occurred on 29 December 2018. For this event, the wind-generated surge
appeared to be the dominant trigger.
Estimating a mean transport velocity in the marginal ice zone using ice–ocean prediction systems
Authors: Sutherland Graig , de Aguiar Victor , Hole Lars-Robert , Rabault Jean , Dabboor Mohammed , Breivik Øyvind 
Published: June 2022

Abstract. Understanding the transport of objects and material in the marginal ice zone (MIZ) is critical for human operations in polar regions. This can be the transport of pollutants, such as spilled oil, or the transport of objects, such as drifting ships and search and rescue operations. For emergency response, the use of environmental prediction systems are required which predict ice and ocean parameters and are run operationally by many centres in the world. As these prediction systems predict both ice and ocean velocities, as well as ice concentration, it must be chosen how to combine these data to best predict the mean transport velocities. In this paper we present a case study of four drifting buoys in the MIZ deployed at four distinct ice concentrations. We compare short-term trajectories, i.e. up to 48 h lead times, with standard transport models using ice and ocean velocities from two operational prediction systems. A new transport model for the MIZ is developed with two key features aimed to help mitigate uncertainties in ice–ocean prediction systems: first, including both ice and ocean velocities and linearly weighting them by ice concentration, and second, allowing for a non-zero leeway to be added to the ice velocity component. This new transport model is found to reduce the error by a factor of 2 to 3 for drifters furthest in the MIZ using ice-based transport models in trajectory location after 48 h.
The antibacterial efficiency of dental powder, toothpastes, mouth rinses, charcoal, table salt and chewing sticks against Streptococcus and Lactobacillus acidophilus
Authors: Ogbe B. , Oviasiogie F. E. , Ikhajiagbe B. 
Published: June 2022

Chewing sticks and other means of obtaining oral health are widely used throughout Africa. But how does the usage of materials compare to the conventional use of fluoride toothpastes for oral hygiene? The aim of the study was to comparatively evaluate the antibacterial efficacy of traditional oral care practices (chewing sticks, dental powders, mouth washes, table salt, and charcoal) and conventional toothpaste against two bacteria strains of public health significance. Standard microbiological and analytical methods were used. Lactobacillus acidophilus ATCC 314TM and Streptococcus mutans ATCC 25175were obtained from the American Type Culture Collection Centre and appropriately reactivated. The stem cuttings of chewing stick (Zanthoxylum zanthoxyloides and Massularia acuminata) were extracted using Soxhlet apparatus. Antibacterial activity of the extracts were done using a modified Kirby-Bauer disk diffusion technique, the minimum inhibitory concentration and minimum bactericidal concentration were carried out using micro dilution technique of double fold dilution. Antibacterial susceptibility testing was done and multiple antibiotic resistance index of the bacterial strain was evaluated thereafter. The results showed that the toothpaste sample labelled B had the highest zone of inhibition (18.00±0.10 cm) and (21.00±0.87 cm) in at a 100% concentration for L. acidophilus and S. mutans respectively. The two chewing stick samples used in the study had antibacterial activity at 100 % concentration for both strains. The mouthwash used in the study tend to have the highest antibacterial activity against S. mutans and L. acidophilus having a diameter (mm) zone of inhibition 26.00±0.20 cm and 24.00±0.95 cm at 100 % concentration respectively. Mouth wash sample met the Clinical Laboratory Standard Institute criterion for reporting the result as sensitive ≥20. Gentamicin, Cefazidime and Meropenem were sensitive to both S. mutans ATCC®25175 and L. acidophilus ATCC®314. Both bacterial strains used in the study had an index greater than 0.2 which symbolizes that they are of public health importance.