bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sufentanil: a risk factor for lactic acidosis in patients after heart valve surgery
Authors: Zhan Yu-Fei , Shi Quan , Pan Yu-Chen , Zheng Bao-Shi , Ge Yi-Peng , Luo Tian-Ge , Xiao Zhi-Hong , Jiang Wei 
Published: September 2022

AbstractBackgroundsHyperlactatemia is a common metabolic disorder after cardiac surgery with cardiopulmonary bypass. Epinephrine use has been identified as a potential cause of increased lactate levels after cardiac surgery. Stress can lead to an increase in catecholamines, mainly epinephrine, in the body. Exogenous epinephrine causes hyperlactatemia, whereas endogenous epinephrine released by stress may have the same effect. Opioids are the most effective anesthetics to suppress the stress response in the body. The authors sought to provide evidence through a retrospective data analysis that helps investigate the relationship between intraoperative opioid dosage and postoperative lactic acidosis after cardiac surgery.MethodsThe clinical data of 215 patients who underwent valvular heart surgery with cardiopulmonary bypass from July 2016 to July 2019 were analyzed retrospectively. Blood lactate levels were measured at 0.1 h, 2 h, 4 h, and 8 h after surgery. Patients with continuous increases in lactate levels and lactate levels exceeding 5 mmol/L at two or more time points were included in the lactic acidosis group, whereas the other patients were included in the control group. First, univariate correlation analysis was used to identify parameters that were significantly different between the two groups, and then multivariate regression analysis was conducted to elucidate the independent risk factors for lactic acidosis. Fifty-one pairs of patients were screened by propensity score matching analysis (PSM). Then, lactic acid levels at four time points in both groups were analyzed by repeated measures ANOVA.Resultshe EF (heart ejection fraction) (OR = 0.94,P = 0.003), aortic occlusion time (OR = 10.17,P < 0.001) and relative infusion rate (OR = 2.23,P = 0.01) of sufentanil was an independent risk factor for lactic acidosis after valvular heart surgery. The patients were further divided into two groups with the mean sufentanil infusion rate as the reference point. The data were filtered with PSM (Propensity Score Matching). Lactic acid values in both groups peaked at 4 h after surgery and then declined. The rate of lactic acid decline was significantly faster in the group with a higher sufentanil dosage than in the lower group. The difference was statistically significant (P < 0.05). There was also a significant difference in lactic acid levels at the four time points (0.1 h, 2 h, 4 h and 8 h after surgery) in both groups (P < 0.001).ConclusionThe inadequate intraoperative infusion rate of sufentanil is an independent risk factor for lactic acidosis after heart valve surgery. The possibility of lactic acidosis caused by this factor after cardiac surgery should be considered, which is helpful for postoperative patient management.
Rapamycin nanoparticles improves drug bioavailability in PLAM treatment by interstitial injection
Authors: Shi Yahong , Jiao Chuqiao , Lu Xi , Nie Yifeng , Li Xiang , Han Dong 
Published: September 2022

Abstract
Background
Pulmonary lymphangiomyomatosis (PLAM) is a rare interstitial lung disease characterized by diffuse cystic changes caused by the destructive proliferation of smooth muscle-like cells or LAM cells. PLAM is more common in young women than other people, and a consensus is lacking regarding PLAM treatment. The clinical treatment of PLAM is currently dominated by rapamycin. By inhibiting the mTOR signaling pathway, rapamycin can inhibit and delay PLAM’s occurrence and development. However, the application of rapamycin also has shortcomings, including the drug’s low oral bioavailability and a high binding rate to hemoglobin, thus significantly decreasing the amount of drug distributed to the lungs.

Methods and results
Here, we developed a new mode of rapamycin administration in which the drug was injected into the intrathecal space after being nanosized; the directional flow characteristics of the liquid in the intrathecal space were exploited to increase the drug content in the interstitial fluid to the greatest extent possible. We studied the rapamycin content in the interstitial fluid and blood after intervaginal space injection (ISI). Compared with oral administration, ISI significantly increased the drug concentration in the lung interstitial fluid.

Conclusions
These results provided new ideas for treating PLAM and optimizing the dosing regimens of drugs with similar characteristics to rapamycin.
A multi-disciplinary, comprehensive approach to management of children with heterotaxy
Authors: Saba Thomas G. , Geddes Gabrielle C. , Ware Stephanie M. , Schidlow David N. , del Nido Pedro J. , Rubalcava Nathan S. , Gadepalli Samir K. , Stillwell Terri , Griffiths Anne , Bennett Murphy Laura M. , Barber Andrew T. , Leigh Margaret W. , Sabin Necia , Shapiro Adam J. 
Published: September 2022

AbstractHeterotaxy (HTX) is a rare condition of abnormal thoraco-abdominal organ arrangement across the left–right axis of the body. The pathogenesis of HTX includes a derangement of the complex signaling at the left–right organizer early in embryogenesis involving motile and non-motile cilia. It can be inherited as a single-gene disorder, a phenotypic feature of a known genetic syndrome or without any clear genetic etiology. Most patients with HTX have complex cardiovascular malformations requiring surgical intervention. Surgical risks are relatively high due to several serious comorbidities often seen in patients with HTX. Asplenia or functional hyposplenism significantly increase the risk for sepsis and therefore require antimicrobial prophylaxis and immediate medical attention with fever. Intestinal rotation abnormalities are common among patients with HTX, although volvulus is rare and surgical correction carries substantial risk. While routine screening for intestinal malrotation is not recommended, providers and families should promptly address symptoms concerning for volvulus and biliary atresia, another serious morbidity more common among patients with HTX. Many patients with HTX have chronic lung disease and should be screened for primary ciliary dyskinesia, a condition of respiratory cilia impairment leading to bronchiectasis. Mental health and neurodevelopmental conditions need to be carefully considered among this population of patients living with a substantial medical burden. Optimal care of children with HTX requires a cohesive team of primary care providers and experienced subspecialists collaborating to provide compassionate, standardized and evidence-based care. In this statement, subspecialty experts experienced in HTX care and research collaborated to provide expert- and evidence-based suggestions addressing the numerous medical issues affecting children living with HTX.
Liver organoids: an in vitro 3D model for liver cancer study
Authors: Dong Renshun , Zhang Bixiang , Zhang Xuewu 
Published: September 2022

AbstractPrimary liver cancer (PLC) is the second leading cause of cancer mortality worldwide, and its morbidity unceasingly increases these years. Hepatitis B virus (HBV) infection accounted for approximately 50% of hepatocellular carcinoma (HCC) cases globally in 2015. Due to the lack of an effective model to study HBV-associated liver carcinogenesis, research has made slow progress. Organoid, an in vitro 3D model which maintains self-organization, has recently emerged as a powerful tool to investigate human diseases. In this review, we first summarize the categories and development of liver organoids. Then, we mainly focus on the functions of culture medium components and applications of organoids for HBV infection and HBV-associated liver cancer studies. Finally, we provide insights into a potential patient-derived organoid model from those infected with HBV based on our study, as well as the limitations and future applications of organoids in liver cancer research.
Collaborative task offloading and resource allocation with hybrid energy supply for UAV-assisted multi-clouds
Authors: Zhou Yu , Ge Hui , Ma Bowen , Zhang Shuhang , Huang Jiwei 
Published: September 2022

AbstractCloud computing has emerged as a promising paradigm for meeting the growing resource demands of Internet of Things (IoT) devices. Meanwhile, with the popularity of mobile aerial base stations, Unmanned Aerial Vehicle (UAV) assisted cloud computing is essential for providing diversified service at areas without available infrastructure. However, it is difficult to meet the requirements of a number of IoT devices which distribute a large area through one single UAV cloud server, and thus multi-clouds have been applied in large-scale IoT environments. Due to the limited battery capacity of UAV, hybrid energy supply has been considered as an effective approach. How to allocate the computing resources and offload the tasks to the UAV-assisted clouds is a challenging task. In this paper, we study the trade-off between the energy consumption and system performance in a UAV-assisted multi-clouds system. Considering the transmission and execution cost, a dynamic optimization problem with the objective of minimizing the power consumption of UAVs with the constraint of queue stability is formulated, which is further decomposed into three sub-problems using stochastic optimization techniques. A collaborative task offloading and resources allocation algorithm (CTORAA) based on artificial intelligent (AI) technique is proposed to jointly determine task offloading and energy harvesting. We provide corresponding mathematical analysis showing that CTORAA can reach the arbitrary profit-stability trade-off. Finally, we conduct simulation experiments to validate the efficacy of our algorithm.
A review of landscape ecology experiments to understand ecological processes
Authors: Wiersma Yolanda F. 
Published: September 2022

AbstractBackgroundOne way in which we make inferences about ecological processes is via experimentation. Many ecological processes happen at landscape extents and it is at this extent that experimentation is more challenging. This review explores the intersection between experimentation, ecological processes and landscape ecology. Specifically, this review seeks to discover how scientists design experiments to understand ecological processes at landscape scales.ResultsI found 87 papers where these three concepts intersected, and reviewed them in more depth to assess characteristics of scale (treatment and study area extent), replication, research question and experiment type.ConclusionsThe findings suggest that experimental approaches for understanding ecological processes are well established, and beginning to more readily accommodate spatial dimensions. However, there is room to integrate more spatially explicit, landscape-scale experiments into studies of ecological processes.
Financial intermediaries and speculation in the foreign exchange market: the role of monetary policy in Iran’s economy
Authors: Sadeghi Abdorasoul , Marzban Hussein , Samadi Ali Hussein , Azarbaiejani Karim , Rostamzadeh Parviz 
Published: September 2022

AbstractGiven the high fluctuations of the general price level, the importance of investment, and accessing sufficient financial resources, we examine the effects of monetary policy on the nominal (Inflation) and real (Investment) sectors of a developing economy, like Iran, through the channel of the relationship between bank deposits, stock market, and speculation in the foreign exchange market (FEM). For this purpose, due to regime switching in Iran’s economy, the non-linear relation between the variables has been investigated by applying Markov switching models and annual data of 1988–2018. The results show that the financial intermediaries (FIs) have not had a complementary relationship in both bear and bull market and high and low banks deposits regimes. Both FIs have negatively impacted speculation in the FEM in high and low exchange rates difference regimes. The difference between official and unofficial exchange rates negatively impacted the FIs in bear market and low banks deposits regimes; on the contrary, a positive effect in a bull market and high bank deposits. The effects of both FIs on investment have been positive in high and low investment regimes and negative on inflation rates in high and very high inflation regimes. In comparison, the impact of speculation in the FEM has been negative on investment and positive on inflation. Therefore, in the event of the lack of limitations regarding using interest rate (IR) and the policy of exchange rate unification, the central bank would be able to affect the nominal and real sectors of the economy suitably through the channels of the FIs and the FEM.
Characterization and insecticidal activity of two natural formulation types against the scale insect (Parlatoria ziziphi) and their biochemical effects on Citrus aurantium
Authors: Abdel-Aziz Nahed Fawzy , Salem Hamdy Abdel-Naby , El-Bakry Ahmed Mohamed , Sammour Elham Ahmed 
Published: September 2022

Abstract
Background
The scale insect, Parlatoria ziziphi (Lucas) (Diaspididae: Hemiptera), is one of the most serious insects in citrus orchards in Egypt. The efficiency of two different formulation types (emulsifiable concentrates (EC) and nanoemulsions) based on the essential oils Artemisia herba-alba (Asso.) (Asterales: Asteraceae) and Laurus nobilis (L.) (Laurales: Lauraceae) at two concentrations of 3 and 5%, compared with the commercial mineral oil, Active Cable, was examined against P. ziziphi. The green formulations were named Artemisia and Laury relative to A. herba-alba and L. nobilis, respectively. The physicochemical properties of the tested formulations have been studied.

Results
All the EC formulations of the essential oils (EOs) as well as the nanoemulsions with ratios of EOs to Tween 1:1.5 (Artemisia) and 1:2 (Laury) passed all the tested characteristics. The droplet sizes of the successful nanoemulsions’ formulations by the ultrasonic emulsification were 153.7, 113.4 nm for Artemisia and 139.3, 89.4 nm for Laury at 3 and 5% concentrations, respectively. Laury EC caused average reductions of 92.79 and 94.94% (nymphs and females) when applied at 3 and 5%, respectively, while the same oil prepared as nanoemulsions caused average reductions of 50.02 and 55.32% at the same concentrations, compared with 91.74% reduction resulted from spraying Active Cable. Moreover, Artemisia caused reduction percentages of 74.97, 91.52 for EC and 43.7, 54.01 for nanoemulsions, sprayed at 3 and 5%, respectively. Although EC emulsions were more effective in reducing insect populations than nanoemulsion formulations, the efficiency of nanoemulsions gradually increased with time elapsed. The antioxidant activities of superoxide dismutase, catalase, and polyphenol oxidase enzymes were researched. It is recognized that insect infestations increase plant enzyme activity to defend them against insect attack. The results revealed a significant reduction of all the examined enzymes which were more obvious for EC emulsions than nanoemulsions.

Conclusions
The EC formulations originated from the EOs, especially Laury 3% EC and Artemisia 5% EC, could be an alternative to the traditional insecticides for controlling the scale insect, P. ziziphi.
COVID-19-induced multisystem inflammatory syndrome in a child with Wilson disease: a case report
Authors: Abdel-Ghaffar Tawhida Yassin , Zakaria Haidy Mohammed , Elsayed Eman Mohamed , Magdy Sondos , El Naghi Suzan , Naeem Suhaib Alsayed Mohammed , Hasan Mahmoud Yosry , khallaf Rabab Qasim 
Published: September 2022

Abstract
Background
Infection with coronavirus disease 2019 (COVID-19) can progress to the multisystem inflammatory syndrome in children (MIS-C). Patients with liver cirrhosis are at increased risk of complications.

Case presentation
We report on a 13-year-old Wilson’s disease patient who was referred for liver transplantation because of rapid deterioration in his hepatic condition. After admission, he developed fever, respiratory distress, coronary arteries dilatation on echocardiography, laboratory evidence of inflammation, and positive severe acute respiratory syndrome coronavirus (SARS-CoV-2) PCR. SARS-CoV-2-induced MIS-C was diagnosed. Inspite of aggressive management of MIS-C, progressive deterioration of the respiratory, liver, kidney, and cardiac functions occurred and he passed away.

Conclusion
MIS-C is a serious possible complication leading to multiorgan failure and higher death rate especially in cirrhotic children. So, early diagnosis and management with higher level of care by a multidisciplinary team are warranted.
Economic policy uncertainty and the US stock market trading: non-ARDL evidence
Authors: Javaheri Bakhtiar , habibi Fateh , Amani Ramin 
Published: September 2022

AbstractThe present study investigates the impact of economic policy uncertainty, and economic factors on the stock market index in the USA using Non-ARDL and Quantile models. The findings reveal that declining economic and economic-political factors will increase the stock market index in the US. The results indicate that the effect of inflation and GDP variables follows a nonlinear pattern. Similar results using quantitative regression showed asymmetric impacts of inflation and GDP on stock market transactions.
Limited impacts of climatic conditions on commercial oil palm yields in Malaysian plantations
Authors: Fleiss Susannah , McClean Colin J. , King Henry , Hill Jane K. 
Published: September 2022

AbstractBackgroundOil palm is a key driver of deforestation, but increasing yields in existing plantations could help meet rising global demands, while avoiding further conversion of natural habitat. Current oil palm plantations present substantial opportunities for sustainable intensification, but the potential for local yield improvements depends partly on the role of climate in determining yield.MethodsWe determine the importance of local climatic conditions for oil palm yields in 12 commercial plantations in Peninsular and East Malaysia (Borneo), during 2006–2017. We quantify relationships between climatic conditions (raw and anomalised monthly temperature and rainfall data) and yield for lag times up to 36 months prior to harvest, corresponding to key stages in oil palm fruit development.ResultsOverall, climatic conditions explained < 1% of the total variation in yield. In contrast, variation in yield among plantations accounted for > 50% of the explained variation in yield (of totalR2 = 0.38; median annual fresh fruit bunch yield 16.4–31.6 t/ha). The main climatic driver of yield was a positive effect of maximum monthly temperature during inflorescence development (Spearman’s Rho = 0.30), suggesting that insufficient solar radiation is the main climatic constraint to yield in our study sites. We also found positive impacts of rainfall during key stages of fruit development (infloresence abortion and sex determination: Spearman’s Rho 0.06 and 0.08 respectively, for rainfall anomalies), suggesting minor effects of water-limitation on yield; and a negative impact of maximum temperature during the month of harvest (Spearman’s Rho – 0.14 for temperature anomalies), suggesting possible heat stress impacts on plantation workers.ConclusionsOur findings imply a relatively minor role of climate in determining yield, and potentially substantial yield gaps in some commercial plantations in Malaysia (possibly up to ~ 50%). Thus, there appear to be substantial opportunities for improving oil palm yield in existing plantations in Malaysia, with further research needed to identify the drivers of such yield gaps.
The management of depression: the evidence speaks for itself
Authors: Malhi Gin S. , Bell Erica , Bassett Darryl , Boyce Philip , Bryant Richard , Hopwood Malcolm , Lyndon Bill , Mulder Roger , Porter Richard , Singh Ajeet B. , Murray Greg 
Published: September 2022

SummaryComparing the recommendations of two recently published national clinical practice guidelines for depression, this editorial highlights the concordance of advice concerning the selection and sequencing of therapies. Lifestyle and psychological interventions feature prominently and there is broad agreement regarding medication choice and optimisation strategies. The guidelines are therefore a useful resource.
Who Matters Most? Migrant Networks, Tie Strength, and First Rural–Urban Migration to Dakar
Authors: Boujija Yacine , Bignami Simona , Delaunay Valérie , Sandberg John 
Published: September 2022

Abstract
Social networks' influence on migration has long been explored largely through the lenses of cumulative causation and social capital theory. This article aims to reconceptualize elements of these theories for the case of rural–urban migration and test their utility in explaining first-migration timing. We use a uniquely extensive social network survey linked to prospectively collected migration data in rural Senegal. We decompose migrant networks into return migrants, current migrants, and nonmigrant residents of the destination to capture heterogeneity in migration-relevant social capital. As expected, the number of nonmigrant alters living in the capital, Dakar, has an outsized association with the migration hazard, the number of current migrants from the village living in Dakar has a smaller association, and the number of return migrants has little association. Drawing on social capital theory, we test the influence of (1) subjectively assessed tie strength between the ego and their network alters and (2) structurally weak ties measured through second-order (“friend of a friend”) connections. Weak and strong subjective ties to current migrants and nonmigrant Dakar residents are positively associated with the first-migration hazard. Structurally weak ties to current migrants are too, but only for individuals with no direct ties to current migrants.
Caught in a Conflict of Loyalties
Authors: Talbot Cynthia 
Published: September 2022

Abstract
In tribute to Allison Busch, who did so much to restore the reputation of vernacular literature not just as poetry but also as history, Talbot offers an account of an obscure Rajput warrior from Bikaner who decided it would be better to die. In asking why Ramsingh Kalyanmalot sought death in 1577, we must address the larger issue of the changes wrought on the Rajput world by the expanding power of the Mughal empire, one of the main questions that Busch probed in her research. Vernacular texts composed at Rajput courts not only provide a valuable alternate perspective on the power dynamics of the Mughal era, as Busch repeatedly pointed out, but can also cast light on the lives of locally powerful men who hardly figure in imperially sponsored Persian histories. In Dalpat Vilas, a prose biography composed in Marwari, we witness the dilemma of Ramsingh, a second son who was caught between his older brother, the Bikaner Raja and obedient Mughal servant, and his younger brothers, occasional bandits who wandered freely. Their story illustrates how competing loyalties and priorities could strain brotherly bonds, especially in times of political turmoil.