bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of perioperative chemotherapy and radiotherapy for localized high-grade malignant peripheral nerve sheath tumor at the extremities and trunk wall: a population-based cohort study
Authors: Kobayashi Hiroshi , Zhang Liuzhe , Okajima Koichi , Hirai Toshihide , Tsuda Yusuke , Ikegami Masachika , Kawai Akira , Tanaka Sakae 
Published: December 2022

Abstract

Background
Primary tumor resection is the mainstay of treatment for malignant peripheral nerve sheath tumors. However, the efficacy of perioperative chemotherapy and radiotherapy for malignant peripheral nerve sheath tumors has not been elucidated.

Methods
This retrospective analysis based on a Japanese registry included patients with localized malignant peripheral nerve sheath tumors arising at the extremities and trunk wall. Disease-specific overall survival and local recurrence-free survival were estimated using the Kaplan–Meier method. A Cox regression model was used to identify prognostic factors. Characteristics of groups with or without chemotherapy were adjusted using propensity score matching.

Results
In total, 291 patients were included. The 5-year disease-specific overall survival rate was 70.6%. Multivariate analysis of disease-specific overall survival revealed that deep-seated tumors were a poor prognostic factor, but perioperative chemotherapy was not associated with disease-specific overall survival (hazard ratio, 0.81; 95% confidence interval, 0.45–1.43, P = 0.46). Local recurrence was observed in 55 patients (19.0%), and surgical margins (R1 and R2) were significant risk factors. Overall, perioperative chemotherapy did not prolong disease-specific overall survival (5-year disease-specific overall survival: 74.1% vs. 69.3%, P = 0.75) and had limited efficacy in the group with tumor size ≥ 5 cm, although the difference was not statistically significant (5-year disease-specific overall survival: 77.2% vs. 68.6%, respectively, P = 0.13). After adjustment by propensity score matching, perioperative chemotherapy significantly prolonged disease-specific overall survival (5-year disease-specific overall survival: 74.9% vs. 57.1%, P = 0.03), but this effect was not observed in local recurrence-free survival. In all patients, perioperative radiotherapy did not correlate with local recurrence-free survival (hazard ratio, 1.43; 95% confidence interval 0.78–2.62, P = 0.25).

Conclusions
Perioperative chemotherapy had limited efficacy for disease-specific overall survival in patients with localized malignant peripheral nerve sheath tumors.
Phlebotominae Fauna (Diptera: Psychodidae) and the Spatial Distribution of Species in Sergipe, Brazil
Authors: Andrade David Campos , Lima Antônio Fernando Viana de Assis , Jeraldo Verónica de Lourdes Sierpe , de Melo Cláudia Moura , Pinto Mara Cristina , Madi Rubens Riscala 
Published: December 2022

AbstractSome sand fly species are the vectors responsible for the transmission of Leishmania spp. (Kinetoplastida: Trypanosomatidae), the etiological agent of leishmaniasis, and in the state of Sergipe, the two main forms of the disease (visceral and cutaneous) are recorded. Few works show information about the species that form the Phlebotominae fauna in Sergipe. This study aimed to update and determine how they are distributed throughout the state. The study used data from surveys about phlebotomines in Sergipe, from the Program of Surveillance and Control of Visceral Leishmaniasis, carried out by the Central Public Health Laboratory of Sergipe, from 2008 to 2018, along with review and original data from 2022. The commentary on this information was developed with focus on the species that can be vectors for the disease. Sergipe has, up to now, 27 registered species of phlebotomines from 12 genera, 15 of them are of sanitary relevance. Twenty two of these species are in the mesoregion East, 19 in the Agreste, and 11 in the Sertão of Sergipe. The species with the greatest distribution was Evandromyia lenti (Mangabeira, 1938), present in 74.6% of the municipalities of Sergipe, followed by Lutzomyia longipalpis (Lutz & Neiva, 1912), the main vector of the etiological agent of visceral leishmaniasis in Brazil, present in 68% of the municipalities studied. This study expands the number and distribution of species recorded in the state. This information can contribute to disease containment plans and support health education actions aimed at the control of leishmaniasis in Sergipe.
Racial survival disparities in head and neck cancer clinical trials
Authors: Liu Jeffrey C , Egleston Brian L , Blackman Elizabeth , Ragin Camille 
Published: December 2022

Abstract

Background
Survival disparities between Black and White head and neck cancer patients are well documented, with access to care and socioeconomic status as major contributors. We set out to assess the role of self-reported race in head and neck cancer by evaluating treatment outcomes of patients enrolled in clinical trials, where access to care and socioeconomic status confounders are minimized.

Methods
Clinical trial data from the Radiation Therapy Oncology Group studies were obtained. Studies were included if they were therapeutic trials that employed survival as an endpoint. Studies that did not report survival as an endpoint were excluded; 7 Radiation Therapy Oncology Group Studies were included for study. For each Black patient enrolled in a clinical trial, a study arm–matched White patient was used as a control.

Results
A total of 468 Black participants were identified and matched with 468 White study arm–specific controls. White participants had better outcomes than Black participants in 60% of matched pairs (P &lt; .001). Black participants were consistently more likely to have worse outcomes. When outcomes were measured by progression-free survival or disease-free survival, the failure rate was statistically significantly higher in Black participants (hazard ratio [HR] = 1.50, P &lt; .001). Failure was largely due to locoregional failure, and Black participants were at higher risk (subdistribution HR =1.51, P = .002). The development of distant metastasis within the paired cohorts was not statistically significantly different.

Conclusion
In this study of clinical trial participants using self-reported race, Black participants consistently had worse outcomes in comparison to study arm–specific White controls. Further study is needed to confirm these findings and to explore causes underlying this disparity.
Impact of Penicillin Allergy Labels on Children Treated for Outpatient Respiratory Infections
Authors: Joerger Torsten , Taylor Margaret G , Li Yun , Palazzi Debra L , Gerber Jeffrey S 
Published: December 2022

AbstractBackgroundPenicillin allergy is the most common antibiotic allergy, yet most children labeled as allergic tolerate penicillin. The impact of inaccurate penicillin allergy labels (PALs) on pediatric outpatients is unknown. The objective of this study was to compare outcomes between children with and without a PAL after treatment for outpatient respiratory tract infections (RTI).MethodsA retrospective, longitudinal birth cohort study was performed in children who received care in 90 pediatric primary care practices in Philadelphia and Houston metropolitan areas. Prescribing and clinical outcomes of children with a PAL at the time of an RTI were compared to non-allergic children, adjusting for potential confounders.ResultsAntibiotics were prescribed for 663,473 non-recurrent RTIs among 200,977 children. Children with a PAL (5% of cohort) were more likely than non-allergic children to receive broad-spectrum antibiotics (adjusted relative risk (aRR) 3.24, 95% CI 3.22-3.26) and second-line antibiotics (aRR 4.87, 95% CI 4.83, 4.89). Compared to non-allergic children receiving first-line antibiotics, children with a PAL were more likely to return with adverse drug events (aRR 1.28, 95% CI 1.18–1.39). There was no difference in treatment failure between groups (aRR 0.95, 95% CI 0.90–1.00).ConclusionsPALs lead to higher rates of broad-spectrum and second-line antibiotic prescribing in children treated for RTIs in primary care and contribute to unnecessary healthcare utilization through increased adverse events. Given the frequency of PALs, efforts to prevent inappropriate penicillin allergy labeling and promote de-labeling of existing inaccurate allergy labels may improve care of children treated for common bacterial infections.
Complementary water and nutrient utilization of perianth structural units help maintain long floral lifespan inDendrobium
Authors: Li Jia-Wei , Zhou Yi , Zhang Zi-Bin , Cui Xue-Qiang , Li Hong-Yan , Ou Mei-Jing , Cao Kun-Fang , Zhang Shi-Bao 
Published: December 2022

AbstractMost orchids have high ornamental value with long-lived flowers. However, the mechanisms by which orchids maintain floral longevity are poorly understood. Here, we hypothesized that floral longevity in Dendrobium is maintained by high resource investment and complementary water and nutrient utilization in different structural units of the perianth. To test this hypothesis, we determined which water- and nutrient-related traits are correlated with flower longevity in 23 Dendrobium species or cultivars, and examined variations of the related traits during flower development of one long-lived cultivar. We found that floral longevity was correlated with dry mass per unit area of perianths and total flower biomass, which indicates that maintaining floral longevity requires increased resource investment. During development of long-lived flowers, labella showed a high capacity for water storage and nutrient reutilization, which could partly remedy high water demand and biomass investment. Sepals and petals, in contrast, had stronger desiccation avoidance and higher metabolic activity with lower biomass investment. These findings indicate that Dendrobium flowers maintain longevity by complementary water and nutrient utilization strategies in the sepals, petals and labella, with labella consuming more water and nutrients to extend flower display, and sepals and petals using a more conservative strategy.
Characterization of lodging variation of weedy rice
Authors: Wang Haoquan , Lu Huan , Yang Zixuan , Zhang Zixu , Li Mengshuo , Zhang Zheng , Dai Weimin , Song Xiaoling , Olsen Kenneth M , Qiang Sheng 
Published: December 2022

AbstractWeedy rice (Oryza spp.), one of the most notorious weeds of cultivated rice, evades eradication through stem lodging and seed shattering. Many studies have focused on seed shattering, whereas variations in lodging have received less attention and the underlying mechanisms that cause the differences in lodging between weedy and cultivated rice have not been studied in detail. Here, we compared lodging variation among diverse Chinese weedy rice strains and between weedy rice and co-occurring cultivated rice. The chemical composition of basal stems was determined, and transcriptome and methylome sequencing were used to assess the variation in expression of lodging-related genes. The results showed that the degree of lodging varied between indica-derived weed strains with high lodging levels, which occurred predominantly in southern China, and japonica-derived strains with lower lodging levels, which were found primarily in the north. The more lodging-prone indica weedy rice had a smaller bending stress and lower lignin content than non-lodging accessions. In comparison to co-occurring cultivated rice, there was a lower ratio of cellulose to lignin content in the lodging-prone weedy rice. Variation in DNA methylation of lignin synthesis-related OsSWN1, OsMYBX9, OsPAL1, and Os4CL3 mediated the differences in their expression levels and affected the ratio of cellulose to lignin content. Taken together, our results show that DNA methylation in lignin-related genes regulates variations in stem strength and lodging in weedy rice, and between weed strains and co-occurring cultivated rice.
Rfd1, a restorer to theAegilops juvenaliscytoplasm, functions in fertility restoration of wheat cytoplasmic male sterility
Authors: Niu Fuqiang , Bu Yaning , Yang Xuetong , Wu Yongfeng , He Mengting , Zhang Lingli , Song Xiyue 
Published: December 2022

AbstractCytoplasmic male sterility (CMS) is a crucial means for the utilization of heterosis, which is of great significance for improving the yield and quality of hybrids. Currently, fertility restoration has been extensively investigated in crops, but fertility restoration of CMS wheat with Aegilops juvenalis cytoplasm is poorly understood. Here, a backcross population BC1F1 derived from a cross between the male-sterile line Ju706A, its maintainer line 706B, and restorer line LK783 was used to map the Rfd1 locus by bulked segregant analysis and wheat 660K single nucleotide polymorphism genotyping. Ju706A displayed complete male sterility, and its fertility can be restored by LK783 with a pair of dominant genes Rfd1Rfd1. The locus was located to a 2.4 Mb region on chromosome 1BS by markers AX-174254104 and AX-111201011. Combined with transcriptomic analysis and quantitative real-time PCR assay, TraesCS1B02G197400LC, the most likely candidate gene for Rfd1, was found to encode a pectinesterase that was localized in the cell wall, and was highly expressed in fertile anthers. The silencing of Rfd1 resulted in decreased fertility, and heterogeneous expression of Rfd1 promoted pollen germination and affected vegetative growth. This implies that Rfd1 is required for anther or pollen development and male fertility in CMS wheat with Ae. juvenalis cytoplasm. Furthermore, a 7 bp deletion in Ju706A was employed to develop a specific marker, Xnwafu1, for molecular marker-assisted selection of restorers. This study provides a new understanding for exploring the fertility restoration mechanism of CMS.
Perforating Calcinosis Cutis as a Complication of Intraosseous Fluid Infusion in the Setting of a Near-Drowning Event
Authors: Marinelli Lisa M , Arballo Olivia M , Guerrero Giselle , Wohltmann Wendi E 
Published: December 2022

ABSTRACT
Iatrogenic calcinosis cutis represents a subset of calcinosis cutis resulting secondary to treatments or procedures. We present the first report of calcinosis cutis resulting from the intraosseous infusion and one of a few cases with associated transepidermal elimination. A previously healthy 2-year-old female presented with a new-onset unilateral shin rash 1 week following hospitalization for a near-drowning event. A dermatologic exam revealed multiple small, tender, firm, chalky-white papules with surrounding erythema, in addition to two erythematous macules superior and medial to the papular lesions, corresponding to prior intraosseous access sites. The rash persisted despite trials of topical mupirocin and acyclovir cream, prompting a referral to a dermatologist. An excisional biopsy was performed, revealing circumscribed dermal deposits of acellular basophilic material connected to the overlying epidermis through an invaginated keratin plug. A von Kossa silver stain highlighted the deposits, confirming the diagnosis of perforating calcinosis cutis. The lesions did not recur following the excisional biopsy. Iatrogenic calcinosis cutis may be seen as a complication of the infusion of calcium-containing fluids via intraosseous access, in addition to the more commonly observed peripheral intravenous access. Awareness of this disorder is important in order to distinguish it from an infectious mimic and guide the selection of therapy.
FIRE-3: updated stellar evolution models, yields, and microphysics and fitting functions for applications in galaxy simulations
Authors: Hopkins Philip F , Wetzel Andrew , Wheeler Coral , Sanderson Robyn , Grudić Michael Y , Sameie Omid , Boylan-Kolchin Michael , Orr Matthew , Ma Xiangcheng , Faucher-Giguère Claude-André , Kereš Dušan , Quataert Eliot , Su Kung-Yi , Moreno Jorge , Feldmann Robert , Bullock James S , Loebman Sarah R , Anglés-Alcázar Daniel , Stern Jonathan , Necib Lina , Choban Caleb R , Hayward Christopher C 
Published: December 2022

ABSTRACT
Increasingly, uncertainties in predictions from galaxy formation simulations (at sub-Milky Way masses) are dominated by uncertainties in stellar evolution inputs. In this paper, we present the full set of updates from the Feedback In Realistic Environment (FIRE)-2 version of the FIRE project code, to the next version, FIRE-3. While the transition from FIRE-1 to FIRE-2 focused on improving numerical methods, here we update the stellar evolution tracks used to determine stellar feedback inputs, e.g. stellar mass-loss (O/B and AGB), spectra (luminosities and ionization rates), and supernova rates (core-collapse and Ia), as well as detailed mass-dependent yields. We also update the low-temperature cooling and chemistry, to enable improved accuracy at $T \lesssim 10^{4}\,$K and densities $n\gg 1\, {\rm cm^{-3}}$, and the meta-galactic ionizing background. All of these synthesize newer empirical constraints on these quantities and updated stellar evolution and yield models from a number of groups, addressing different aspects of stellar evolution. To make the updated models as accessible as possible, we provide fitting functions for all of the relevant updated tracks, yields, etc, in a form specifically designed so they can be directly ‘plugged in’ to existing galaxy formation simulations. We also summarize the default FIRE-3 implementations of ‘optional’ physics, including spectrally resolved cosmic rays and supermassive black hole growth and feedback.
The cosmic shallows – I. Interaction of CMB photons in extended galaxy haloes
Authors: Luparello Heliana E , Boero Ezequiel F , Lares Marcelo , Sánchez Ariel G , Lambas Diego Garcia 
Published: December 2022

ABSTRACT
We report and analyse a serendipitous finding of foregrounds in the cosmic microwave background (CMB) radiation associated with extended galactic haloes. Using the cross-correlation of Planck and Wilkinson Microwave Anisotropy Probe maps and the 2MRS galaxy catalogue, we find that the mean temperature radial profiles around nearby galaxies at $cz\le 4500~\rm {km~s^{-1}}$ show a statistically significant systematic decrease of $\sim 15~\mu \rm {K}$ extending up to several galaxy radii. This deficit in the temperature strongly depends on the galaxy morphological type at scales within several tens of times the galaxy size, becoming nearly independent of galaxy morphology at larger scales. The effect is significantly stronger for the more extended galaxies, with galaxy clustering having a large impact on the results. Our findings indicate the presence of statistically relevant foregrounds in the CMB maps that should be considered in detailed cosmological studies. Besides, we argue that these can be used to explore the intergalactic medium surrounding bright late-type galaxies and allow for diverse astrophysical analyses.
Flares in the changing look AGN Mrk 590 – I. The UV response to X-ray outbursts suggests a more complex reprocessing geometry than a standard disc
Authors: Lawther D , Vestergaard M , Raimundo S , Koay J Y , Peterson B M , Fan X , Grupe D , Mathur S 
Published: December 2022

ABSTRACT
Mrk 590 is a known changing-look active galactic nuclei (AGNs) which almost turned off in 2012, and then in 2017 partially re-ignited into a repeat flaring state, unusual for an AGN. Our Swift observations since 2013 allow us to characterize the accretion-generated emission and its reprocessing in the central engine of a changing-look AGN. The X-ray and UV variability amplitudes are higher than those typically observed in ‘steady-state’ AGN at similar moderate accretion rates; instead, the variability is similar to that of highly accreting AGN. The unusually strong X-ray to UV correlation suggests that the UV-emitting region is directly illuminated by X-ray outbursts. We find evidence that the X-rays are reprocessed by two UV components, with the dominant one at ∼3 d and a faint additional reprocessor at near-zero lag. However, we exclude a significant contribution from diffuse broad line region continuum, known to contribute for bonafide AGN. A near-zero lag is expected for a standard ‘lamp-post’ disc reprocessing model with a driving continuum source near the black hole. That the overall UV response is dominated by the ∼3-d lagged component suggests a complicated reprocessing geometry, with most of the UV continuum not produced in a compact disc, as also found in recent studies of NGC 5548 and NGC 4151. None the less, the observed flares display characteristic time-scales of ∼100 rest-frame days, consistent with the expected thermal time-scale in an accretion disc.
What can Gaussian processes really tell us about supernova light curves? Consequences for Type II(b) morphologies and genealogies
Authors: Stevance H F , Lee A 
Published: December 2022

ABSTRACT
Machine learning has become widely used in astronomy. Gaussian process (GP) regression in particular has been employed a number of times to fit or resample supernova (SN) light curves, however by their nature typical GP models are not suited to fit SN photometric data and they will be prone to overfitting. Recently GP resampling was used in the context of studying the morphologies of Type II and IIb SNe and they were found to be clearly distinct with respect to four parameters: the rise time (trise), the magnitude difference between 40 and 30 d post-explosion (Δm40–30), the earliest maximum (post-peak) of the first derivative (dm1), and minimum of the second derivative (dm2). Here we take a close look at GP regression and its limitations in the context of SN light curves in general, and we also discuss the uncertainties on these specific parameters, finding that dm1 and dm2 cannot give reliable astrophysical information. We do reproduce the clustering in trise–Δm40–30 space, although it is not as clear cut as previously presented. The best strategy to accurately populate the trise–Δm40–30 space will be to use an expanded sample of high-quality light curves [such as those in the Asteroid Terrestrial-impact Last Alert System (ATLAS) transient survey] and analytical fitting methods. Finally, using the bpass fiducial models, we predict that future photometric studies will reveal clear clustering of the Type IIb and II light curve morphologies with a distinct continuum of transitional events.
The circumgalactic medium of Milky Way-like galaxies in the TNG50 simulation – I: halo gas properties and the role of SMBH feedback
Authors: Ramesh Rahul , Nelson Dylan , Pillepich Annalisa 
Published: December 2022

ABSTRACT
We analyse the physical properties of gas in the circumgalactic medium (CGM) of 132 Milky Way (MW)-like galaxies at z = 0 from the cosmological magneto-hydrodynamical simulation TNG50, part of the IllustrisTNG project. The properties and abundance of CGM gas across the sample are diverse, and the fractional budgets of different phases (cold, warm, and hot), as well as neutral H i mass and metal mass, vary considerably. Over our stellar mass range of $10^{10.5} &lt; M_\star /{\rm M}_\odot &lt; 10^{10.9}$, radial profiles of gas physical properties from $0.15 &lt; R/R_{\rm 200c} &lt; 1.0$ reveal great CGM structural complexity, with significant variations both at fixed distance around individual galaxies, and across different galaxies. CGM gas is multiphase: the distributions of density, temperature, and entropy are all multimodal, while metallicity and thermal pressure distributions are unimodal; all are broad. We present predictions for magnetic fields in MW-like haloes: a median field strength of $|B|\sim 1\,\mu{\rm G}$ in the inner halo decreases rapidly at larger distance, while magnetic pressure dominates over thermal pressure only within ${\sim}0.2 \times R_{\rm 200c}$. Virial temperature gas at ${\sim}10^6\,{\rm K}$ coexists with a subdominant cool, $\lt 10^5\,{\rm K}$, component in approximate pressure equilibrium. Finally, the physical properties of the CGM are tightly connected to the galactic star formation rate, in turn dependent on feedback from supermassive black holes (SMBHs). In TNG50, we find that energy from SMBH-driven kinetic winds generates high-velocity outflows (≳500–2000 km s−1), heats gas to supervirial temperatures (&gt;106.5–7 K), and regulates the net balance of inflows versus outflows in otherwise quasi-static gaseous haloes.