bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capacidades dinámicas generadoras de valor agregado en las empresas agroindustriales de la provincia de El Oro.
Authors: Bustamante-Jumbo Silvana , Castillo-Cruz Genesis , Pacheco-Molina Andrés , Mora-Sanchez Norman 
Published: December 2022

Las capacidades dinámicas en la actualidad permiten a las empresas adaptarse a las nuevas condiciones del mercado, por lo tanto, el presente trabajo tiene por objetivo establecer las capacidades dinámicas que conllevan a las empresas agroindustriales a generar valor agregado para potencializar el negocio y el crecimiento sostenible. La metodología aplicada es de enfoque cualitativo, por el método inductivo deductivo, donde se analizaron datos provenientes de seis empresas agroindustriales de la provincia de El Oro, donde se examinaron las variables capacidades dinámicas y valor agregado. Entre los principales hallazgos, se obtuvo como capacidad dinámica generadora de valor agregado a la de innovación, que al implementarla el principal aspecto que se consiguió fue el incremento de la productividad; en cuanto al beneficio que generó fue la reducción de la incertidumbre en la comercialización de los productos y detección de nuevas oportunidades en el mercado, además entre los factores que potencializaron la comercialización fueron: la calidad, precio y la gestión ambiental; de lo anteriormente expuesto, se concluyó que la CD de innovación a más de generar valor agregado ayudó al desarrollo económico y productivo de las organizaciones, puesto que al innovar facilita la generación de estrategias y ventajas competitivas.
Palabras Claves:
Capacidades dinámicas, empresas agroindustriales, valor agregado, innovación
La rete dialitica ai tempi della pandemia Covid: prospettive strutturali
Authors: Bonucchi Decenzio , Portale Grazie 
Published: December 2022

Risk profile of dialysis people as regards Covid 19 pandemic is unique; they stay together for some hours in an open-space, sharing transport before and after treatment as a shuttle between families and dialysis centre. As demonstrated by the waves of pandemic, isolation becomes more and more difficult, especially in centres lacking pathways and spaces devoted to contaminated patients. In our setting, dialysis centres were born as marginal areas, discarded from other uses and their design was seldom addressed to out-patients treatment. Logistic and preventive needs (spaces, distances, pathways) were often laid down to a social vision of dialysis. We describe our immediate response to adapt a network of public dialysis centres to pandemic. These measures, and the dedication of our personnel, resulted in a very low mortality rate, but we are still reporting a progressive increase of Covid patients. Organizational response becomes useless without structural changes. We therefore propose a plan oriented to transform dialysis centres into dynamic and safe places of care. Since other pandemics are expected in the future, it appears mandatory to redirect our choices towards a more conservative approach in designing a dialysis point of care, resembling the isolated pavilions of older hospital buildings. Separate entries and exits, mobile walls and large waiting rooms are needed; some personnel redundancy will be required in spite of lean management principles, strongly disproved by Covid. Dialysis rebuilding will be an extraordinary opportunity to create a sustainable way of treatment.
Klasifikasi kata kerja tak ergatif dan kata kerja tak akusatif dalam Bahasa Melayu: Agentiviti dan penamat
Authors: Yusof Maslida , Bustaman Mughni Murni , Abd Wahab Kartini 
Published: December 2022

Makalah ini bertujuan membincangkan sifat semantik kata kerja tak ergatif dan kata kerja tak akusatif bahasa Melayu. Berdasarkan Hipotesis Tak Akusatif, kata kerja tak transitif dibahagikan kepada kata kerja tak akusatif dan kata kerja tak ergatif. Kedua-dua subkelas kata kerja tak transitif ini kelihatan sama pada tahap permukaan tetapi mempunyai representasi sintaksis yang berbeza. Dengan menggunakan analisis semantik yang berdasarkan klasifikasi kata kerja Aktionsart dalam teori Role and Reference Grammar (RRG), makalah ini akan memberi perhatian kepada konsep aspektual agentiviti dan penamat yang mewujudkan perbezaan antara kedua-dua kata kerja tersebut. Klasifikasi kata kerja Aktionsart yang membahagikan kata kerja kepada kata kerja keadaan, aktiviti, penyempurnaan dan pencapaian membuktikan bahawa ciri agentiviti hanya terdapat dalam kata kerja aktiviti dan ciri penamat terdapat pada kata kerja keadaan, penyempurnaan dan pencapaian. Dari perspektif Aktionsart, apabila kata kerja tak transitif ialah proses (atau aktiviti) maka kata kerja ini dipetakan sebagai tak ergatif manakala apabila kata kerja ini bertitik penamat, maka ia direalisasikan sebagai tak akusatif. Secara tidak langsung, makalah ini membuktikan penamat dan agentiviti mendasari perbezaan dalam subklasifikasi tak transitif secara merentas linguistik.
Extraction and purification of antioxidative flavonoids from Chionanthus retusa leaf
Authors: Wang Zhen , Yang Shilong , Gao Yajun , Huang Jianting 
Published: December 2022

In this work, flavonoids from the leaves of Chionanthus retusa were extracted using alcohol, and the extraction yield was optimized by single-factor and orthogonal experiments. Then, the extracted solution with flavonoids was purified via macroporous resin by elution with different concentrations of ethanol. The antioxidative activity of total flavonoid in purified extracted solution was evaluated by detecting its ability to scavenge DPPH free radicals. The results demonstrated that ethanol with a concentration of 60%, ultrasonic power of 140 W, liquid–solid ratio of 25:1 ml g−1, and water-bath temperature of 80°C were the optimal conditions for the extraction of total flavonoids from C. retusa leaf, achieving a yield of 121.28 mg g−1. After purification by macroporous resin using different concentrations of ethanol, the highest content of total flavonoids (88.51%) in the extracted solution can be obtained with the 50% ethanol eluant. The results of scavenging DPPH free radicals suggest that the purified flavonoids in the 50% ethanol eluant had the best antioxidant capacity over the flavonoids in other ethanol eluants. In addition, it is confirmed the antioxidant capacity of the extractives was associated with the content of total flavonoids and kinds of flavonoids. These results may provide a feasible pathway to make full use of total flavonoids from C. retusa leaf.
Growth factor for therapeutic angiogenesis in ischemic heart disease: A meta-analysis of randomized controlled trials
Authors: Tan Ling , Long Lin-Zi , Li Hong-Zheng , Yang Wen-Wen , Peng Yu-Xuan , Lu Jie-Ming , Liao Fei-Fei , Ma Xiao-Chang , Qu Hua , Fu Chang-Geng , Zhang Shan-Shan 
Published: December 2022

Aim: This study was designed to systematically evaluate the effects of growth factor (GF) for therapeutic angiogenesis on ischemic heart disease (IHD) by pooling the results of randomized controlled trials (RCTs).Methods and Results: PubMed, EMBASE, and CENTRAL databases were searched from inception to October 2022. RCTs, investigating the effects of GF therapy on IHD, were included. The risk bias of included study was assessed according to Cochrane tool. Weighted mean difference (WMD), calculated with fixed effect model or random effect model, was used to evaluate the effects of GF therapy on left ventricular ejection fraction (LVEF) and Canadian Cardiovascular Society (CCS) angina class. Relative risk (RR) was used to evaluate the effects of GF therapy on all-cause mortality, major adverse cardiovascular events (MACE) and revascularization. Meta-analysis, meta-regression analysis and publication bias analysis were performed by RevMan 5.3 or Stata 15.1 software. Twenty-nine studies involving 2899 IHD patients (1,577 patients in GF group and 1,322 patients in control group) were included. Compared with the control group, GF therapy did not reduce all-cause mortality (RR: 0.82; 95% CI: 0.54–1.24; p = 0.341), MACE [(RR: 0.83; 95% CI: 0.61–1.12; p = 0.227), revascularization (RR: 1.27, 95% CI: 0.82–1.96, p = 0.290) and CCS angina class (WMD: −0.08, 95% CI: −0.36 to 0.20, p = 0.560). However, GF therapy could increase LVEF during short-term follow-up (&lt;1 year).Conclusion: GF for therapeutic angiogenesis was beneficial for increasing LVEF during short-term follow-up (&lt;1 year), however, the therapy was not efficacious in decreasing all-cause mortality, MACE and revascularization.
Risk factors of chronic kidney disease among type 2 diabetic patients with longer duration of diabetes
Authors: Siddiqui Khalid , George Teena P. , Joy Salini S. , Alfadda Assim A. 
Published: December 2022

BackgroundChronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM) is the major cause of end stage renal disease, characterized by proteinuria with a subsequent decline in glomerular filtration rate. Although hyperglycemia is the major risk factor for the development and progression of kidney disease among diabetic patients, many other risk factors also contribute to structural and functional changes in the kidneys. As recommended by Kidney Disease Improving Global Outcomes (KDIGO), CKD classification based on cause and severity, links to risk of adverse outcomes including mortality and kidney outcomes.ObjectiveThe aim of this study is to investigate the involvement of risk factors associated with the severity of CKD among participants with longer duration of diabetes. This study also aims to find whether number of risk factors vary among risk of CKD progression categories based on KDIGO classification.Material and methodsThis cross-sectional study retrospectively selected 424 participants from type 2 diabetic cohort and categorized them based on the classifications for the diagnosis of kidney diseases in patients with diabetes, according to the KDIGO guidelines. Odds ratios and 95% CI of each risk factors according to severity of renal disease were determined.ResultsBased on KDIGO classification, participants with type 2 diabetes (T2D) were categorized in to low risk (n=174); moderately increased risk (n=98); and high/very high risk (n=152). Type 2 diabetic participants with risk factors such as, hyperlipidemia, hypertension, DM duration ≥15 years and diabetic retinopathy showed a high/very high risk of CKD progression when compared with low-risk category. While T2D participants with risk factors such as, lack of exercise, hypertension, and diabetic retinopathy showed a moderately increased risk of CKD progression. In addition, participants with highest number of risk factors were significantly distributed among high/very high risk of CKD progression category.ConclusionThis study findings conclude that patients with T2DM and duration of ≥15 years, hyperlipidemia, hypertension and diabetic retinopathy have an increased prevalence of advanced CKD. In addition to this, increased number of risk factors could be an indicator of the severity of CKD in T2D.
The molecular basis of the associations between non-alcoholic fatty liver disease and colorectal cancer
Authors: Qiu Ting , Hu Weitao , Rao Zilan , Fang Taiyong 
Published: December 2022

Background: Given the ongoing research on non-alcoholic fatty liver disease (NAFLD) and colorectal cancer (CRC), the number of studies suggesting a strong link between NAFLD and CRC is on the rise, while its underlying pathological mechanisms remain uncertain. This study aims to explore the shared genes and mechanisms and to reveal the molecular basis of the association between CRC and NAFLD through bioinformatics approaches.Methods: The Gene Expression Omnibus (GEO) dataset GSE89632 is downloaded for NAFLD cases and healthy controls. Additionally, the GSE4107 and GSE9348 datasets are obtained for CRC cases and healthy controls. Differentially expressed genes (DEGs) are obtained for NAFLD and CRC datasets, as well as shared genes between the two disorders. GO and KEGG enrichment analyses are further conducted. Subsequently, the STRING database and Cytoscape software are utilized to establish the PPI network and identify the hub genes. Then, co-expression analysis is performed using GeneMANIA. Subsequently, ROC curves and external datasets validation were applied to further screen the candidate markers. Finally, NetworkAnalyst is available as a means to construct a miRNA-gene regulatory network.Results: Under the threshold of FDR ≤ 0.01, 147 common genes are obtained in NAFLD and CRC. Categorization of GO functions shows that DEGs are predominantly enriched in “response to organic substance”, “cellular response to chemical stimulus”, and “response to external stimulus”. The predominant KEGG pathways in DEGs are the “IL-17 signaling pathway”, the “TNF signaling pathway”, “Viral protein interaction with cytokine and cytokine receptor”, “Cytokine-cytokine receptor interaction”, and the “Toll-like receptor signaling pathway”. Additionally, MYC, IL1B, FOS, CXCL8, PTGS2, MMP9, JUN, and IL6 are identified as hub genes by the evaluation of 7 algorithms. With the construction of miRNA-gene networks, 2 miRNAs, including miR-106a-5p, and miR-204-5p are predicted to be potential key miRNAs.Conclusion: This study identifies possible hub genes acting in the co-morbidity of NAFLD and CRC and discovers the interaction of miRNAs and hub genes, providing a novel understanding of the molecular basis for the relevance of CRC and NAFLD, thus contributing to the development of new therapeutic strategies to combat NAFLD and CRC.
Immunogenic change after percutaneous microwave ablation in pulmonary malignancies: Variation in immune cell subsets and cytokines in peripheral blood
Authors: Zhang Liang , Zhang Mingming , Wang Jun , Li Yang , Wang Taijie , Xia Jianguo , Feng Bo , Shen Jialin 
Published: December 2022

IntroductionTo investigate immunogenic changes after percutaneous microwave ablation (MWA) in pulmonary malignancies.MethodsTwenty-two consecutive patients with pulmonary malignancies who underwent percutaneous lung tumor MWA were prospectively enrolled in this study. Peripheral blood samples were collected on the day before (D0) and one month (M1) after MWA. Changes in immune cell subsets (CD3+, CD4+, and CD8+ T cells, and B, natural killer, regulatory T (Treg), and CD3-CD20+ cells) and cytokines (interleukin [IL]-2, 4, 6, 10, 17A, tumor necrosis factor [TNF]-α, and interferon-γ) were noted and compared. Progression-free survival (PFS) and potentially related factors were analyzed.ResultsThe proportion of CD8+ T cells increased from 22.95 ± 7.38% (D0) to 25.95 ± 9.16% (M1) (p = 0.031). The proportion of Treg cells decreased from 10.82 ± 4.52% (D0) to 8.77 ± 2.05% (M1) (p = 0.049). The IL-2 concentration was also decreased from 1.58 ± 0.46 pg/mL (D0) to 1.26 ± 0.60 pg/mL (M1) (p = 0.028). The reduction in Treg cells predicted PFS independently of clinical prognostic features in multivariate analysis (hazard ratio = 4.97, 95% confidence interval: 1.32–18.66, p = 0.018). A reduction in the proportion of Treg cells was observed in 15 patients (68.2%) and the average of the reduction was 2.05 ± 4.60%. Those patients with a reduction in the proportion of Treg cells that was more than average showed a significantly longer median PFS time than those with a reduction that was less than average (16 months vs. 8.5 months, p = 0.025).DiscussionPercutaneous MWA of pulmonary malignancies leads to immunogenic changes. The reduction in the proportion of Treg cells was independently associated with PFS.
Prediction of bronchodilation test in adults with chronic cough suspected of cough variant asthma
Authors: Hao Huijuan , Pan Yilin , Xu Zichong , Xu Zengchao , Bao Wuping , Xue Yishu , Lv Chengjian , Lin Jingwang , Zhang Yingying , Zhang Min 
Published: December 2022

BackgroundMany patients with cough variant asthma (CVA) are underdiagnosed and undertreated due to the atypical symptoms, low diagnostic sensitivity of bronchodilator response (BDR), and limited application of bronchial challenge test.ObjectiveTo investigate whether airway reversibility in BDR can predict CVA diagnosis in patients with chronic cough and negative BDR.MethodsThis open-label, prospective cohort study included patients with chronic cough, nearly normal chest CT scan, and negative BDR results. Inhaled corticosteroids and long-acting β2 agonists were given for 4 weeks. The confirmed diagnosis of CVA was defined as improved symptoms and an increase of forced expiratory volume in 1 s (FEV1) by &gt;12% and &gt;200 mL after 4 weeks of treatment.ResultsOf 155 patients recruited, 140 completed the study. Patients in the CVA positive diagnosis group had greater absolute (Δ) and percent (Δ%) improvements in FEV1 and forced expiratory flows (FEFs), and higher fractional exhaled nitric oxide (FENO) than in the CVA negative diagnosis group. The area under the receiver operating characteristic curves (AUCs) of ΔFEV1%, FEF25–75%pred (percentage of predicted forced expiratory flow at 25% to 75%) and FENO for CVA positive diagnosis was 0.825, 0.714, and 0.637, with cutoff values of 5.90%, 61.99% and 41.50 ppb, respectively. A joint model of ΔFEV1% combined with FEF25–75%pred or FENO increased the AUC to 0.848 and 0.847, respectively.ConclusionΔFEV1% in BDR can predict a CVA diagnosis and response to anti-asthma treatment in patients with chronic cough and negative BDR.Clinical trial registration[http://www.chictr.org.cn/index.aspx], identifier [ChiCTR2000029065].
Impact of physical exercise programs in breast cancer survivors on health-related quality of life, physical fitness, and body composition: Evidence from systematic reviews and meta-analyses
Authors: Joaquim Ana , Leão Inês , Antunes Pedro , Capela Andreia , Viamonte Sofia , Alves Alberto J. , Helguero Luísa A. , Macedo Ana 
Published: December 2022

BackgroundBreast cancer is the most common cancer worldwide, and despite remarkable progress in its treatment, the survivors’ quality of life is hampered by treatment-related side effects that impair psychosocial and physiological outcomes. Several studies have established the benefits of physical exercise in breast cancer survivors in recent years. Physical exercise reduces the impact of treatment-related adverse events to promote a better quality of life and functional outcomes.AimThis study aims to provide an overview of systematic reviews and meta-analyses on the effect of physical exercise on the health-related quality of life, cardiorespiratory fitness, muscle strength, and body composition of breast cancer survivors.MethodsPubMed and Cochrane databases were searched for systematic reviews and meta-analyses from January 2010 to October 2022. The main focus was ascertaining the effectiveness of physical exercise in breast cancer survivors undergoing curative treatment (surgery and/or radiotherapy and/or chemotherapy). Two reviewers independently screened the literature, extracted the data, and assessed the risk of bias in the included studies.ResultsA total of 101 studies were identified, and 12 were yielded for final analysis. The eligible studies included nine systematic reviews/meta-analyses, one meta-analysis/meta-regression, and two systematic reviews. The number of randomised clinical trials included in each review varied from 11 to 63, and the number of participants was from 214 to 5761. A positive and significant effect of different physical exercise interventions on health-related quality of life was reported in 83.3% (10 studies) of the eligible studies. Physical exercise also improved cardiorespiratory fitness (3 studies; 25%) and showed to be effective in reducing body weight (3 studies; 25%) and waist circumference (4 studies; 33.3%).ConclusionsOur results suggest that physical exercise is an effective strategy that positively affects breast cancer survivors’ quality of life, cardiorespiratory fitness, and body composition. Healthcare professionals should foster the adoption of physical exercise interventions to achieve better health outcomes following breast cancer treatments.Systematic review registrationhttps://inplasy.com/inplasy-2022-11-0053/, identifier INPLASY2022110053.
Identification of a cuproptosis-related lncRNA signature to predict the prognosis and immune landscape of head and neck squamous cell carcinoma
Authors: Huang Juntao , Xu Ziqian , Yuan Zhechen , Teh Bing Mei , Zhou Chongchang , Shen Yi 
Published: December 2022

BackgroundCuproptosis is considered a novel copper-induced cell death model regulated by targeting lipoylated TCA cycle proteins. In this study, we established a novel signature based on cuproptosis-related lncRNAs (crlncRNAs) to predict the prognosis and immune landscape of head and neck squamous cell carcinoma.MethodsRNA-seq matrix, somatic mutation files, and clinical data were obtained from The Cancer Genome Atlas database. After dividing patients into two sets, a crlncRNA signature was established based on survival related crlncRNAs, which were selected by the univariate Cox analysis and least absolute shrinkage and selection operator Cox regression. To evaluate the model, Kaplan-Meier survival analysis and time-dependent receiver operating characteristic (ROC) were utilized, and a nomogram was established for survival prediction. Immune landscape analysis, drug sensitivity, cluster analysis, tumor mutation burden (TMB) and ceRNA network analysis were conducted subsequently.ResultsA crlncRNA related prognosis signature was finally constructed with 12 crlncRNAs. The areas under the ROC curves (AUCs) were 0.719, 0.705 and 0.693 respectively for 1, 3, and 5-year’s overall survival (OS). Patients in the low-risk group behaved a better prognosis, lower TMB, higher immune function activity and scores. In addition, patients from cluster 2 were more sensitive to chemotherapy and immunotherapy.ConclusionIn this study, we constructed a novel crlncRNA risk model to predict the survival of HNSCC patients. This reliable and acceptable prognostic signature may guide and promote the progress of novel treatment strategies for HNSCC patients.