bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge Graph Embedding based on Line Graph Attention Mechanism
Authors: Liu Bo , Wu Jiahui , Wu Enju 
Published: November 2022

Abstract

The broad application prospects of knowledge graphs have spawned many research work in the field of knowledge graph completion. In these works, models based on convolution neural networks perform well on link prediction tasks by generating expressive feature embedding. Some models based on graph neural networks also obtain good knowledge graph embedding results by capturing graph structure features and node features in the knowledge graph. However, these models often rely more on the entity features in the triples and ignore the importance of the relationship features, so they cannot guarantee the generalization ability on the triples containing unseen entities. To this end, we propose a method of learning Knowledge Graph embedding on Line Graphs using Graph Attention mechanism (KG-LGAT). By transforming the neighborhood of the target triples on the knowledge graph into a line graph, and using the graph attention mechanism to fuse the relationship features on the line graph, this method cannot only reduce the difficulty of modeling the heterogeneous map structure of the knowledge graph, but strengthen the connection between the triples and the entire knowledge graph, thereby reducing the model’s dependence on entity features. The comparison results with related works on the benchmark data sets WN18RR and FB15k-237 prove the superiority of proposed method.
INDICATORS FOR EVALUATION OF SPECIALIZED DENTAL CENTERS BY EXPERTS CONSENSUS METHOD
Authors: Christiane de Azevedo Machado Flávia , Valdivino da Silva Janmille , De Oliveira Suelen Ferreira 
Published: November 2022

Introdução: Os Centros Dentários Especializados (SDC) devem apoiar a Atenção Primária à Saúde (PHC) dentro de uma complexidade média. Objetivo: Os indicadores de desempenho foram construídos com base em um modelo lógico que ilustra os recursos, atividades, produtos e resultados exigidos por um Centro Odontológico Especializado para cumprir sua missão. Metodologia: Para validá-los, professores, gerentes médios e gerentes (n = 6) atribuíram uma pontuação (0-9) a cada atributo (validade, sensibilidade, especificidade, relevância, simplicidade, custo-benefício, oportunidade) dos indicadores, antes e depois da discussão em grupo. Resultados: Dos 82 indicadores iniciais, 63 foram considerados importantes por consenso (mediana ?7; distância interquartil ?2) relacionados à motivação para o trabalho; absenteísmo às consultas; atmosfera organizacional; segurança do paciente; gestão participativa; recursos financeiros; produtividade; educação em saúde e interação Centro Dentário Especializado/Cuidados Primários formaram a matriz final que prevê subsidiar avaliações de desempenho, principalmente baseadas em processos de trabalho. Conclusões: Assim, é possível ajudar a alcançar a missão do Centro Odontológico Especializado e a construir uma Rede de Saúde Bucal.
Palavras-Chave: Saúde Bucal; Cuidados Secundários; Avaliação em Saúde; Pesquisa sobre Serviços de Saúde.
MORBIMORTALIDADE POR DOENÇAS DO APARELHO RESPIRATÓRIO NO BRASIL: UM ESTUDO ECOLÓGICO
Authors: Alexandrino Arthur , De Queiroz Xavier Bárbara Letícia , Batista de Oliveira Fellipe , Macêdo Venâncio dos Santos Ana Beatriz , Santos Quirino Ana Luiza , Barbosa de Andrade Fábia 
Published: November 2022

Introdução: As doenças do aparelho respiratório se configuram como o segundo principal motivo de internações hospitalares no Brasil entre 2013 e 2017. Objetivo: Analisar a morbimortalidade de doenças do aparelho respiratório da população brasileira, segundo faixa etária, no período compreendido entre os anos de 2015 a 2019. Metodologia: Trata-se de um estudo do tipo ecológico, retrospectivo, realizado sobre o território brasileiro. Os dados foram coletados a partir do Departamento de Informática do Sistema Único de Saúde, nas seções de Morbidade Hospitalar, de Mortalidade e População Residente. Foram analisados os dados entre 2015 a 2019 e de todas as faixas etárias. Resultados: Ao investigar a mortalidade por doenças do sistema respiratório entre os anos de 2015 e 2019, as cinco causas mais frequentes foram: influenza e pneumonia; doenças crônicas das vias aéreas inferiores; outras doenças do aparelho respiratório; outras doenças respiratórias que afetam principalmente interstício; doenças pulmonares devidas a agentes externos, nessa ordem. Enquanto as cinco causas de morbidades mais frequentes foram: pneumonia; outras doenças do aparelho respiratório; bronquite, enfisema e outras doenças pulmonares obstrutivas crônicas; asma; bronquite aguda e bronquiolite aguda. Conclusões: Verificou-se que a pneumonia, influenza, doenças respiratórias do trato inferior e outras doenças crônicas respiratórias foram as mais prevalentes entre a população respectivamente. Dentre o público mais acometido, foi possível constatar que o público infantil e a população idosa foram os mais atingidos tanto na mortalidade quanto na morbidade.
SAÚDE DO HOMEM NA ATENÇÃO BÁSICA: FATORES QUE INFLUENCIAM A BUSCA PELO ATENDIMENTO
Authors: Disney Silva Júnior Clausson , Rodrigues de Souza Jéssica , Santana Silva Natatia , Pereira de Almeida Shirley , Machado Torres Lilian 
Published: November 2022

Introdução: Alguns aspectos influenciam o distanciamento dos homens em buscar atendimento nas Unidades de Saúde. Objetivo: Analisar os fatores que influenciam o atendimento à saúde do homem na Atenção Primária de Saúde. Metodologia: Pesquisa qualitativa realizada em uma Unidade Básica de Saúde de Belo Horizonte. Foram entrevistados homens entre 18 e 59 anos atendidos no referido serviço. O conteúdo dos depoimentos foi submetido à análise temática de conteúdo. Resultados: Os participantes desconhecem a política a eles direcionada e expressaram como se sentem durante a atenção, diante da demora no atendimento e do desejo de serem assistidos como as mulheres. Emergiram três categorias: (Des)Conhecendo as políticas de saúde; A busca pelos serviços de saúde; e A insatisfação dos homens: revelando fatores que dificultam a procura aos serviços de saúde. Conclusões: Urge identificar a satisfação do público alvo. Capacitação e sensibilização permanentes das equipes concorrem para melhorias do cuidado cotidiano.
Palavras-Chave: Saúde do Homem; Enfermagem; Atenção Primária à Saúde; Satisfação do Paciente.
The Radioprotective Potentials of Silymarin/Silibinin Against Radiotherapy-
Induced Toxicities: A Systematic Review of Clinical and Experimental
Studies
Authors: Latacela Gloria Alexandra , Ramaiah Pushpamala , Patra Indrajit , Jalil Abduladheem Turki , Gupta Reena , Madaminov Fakhriddin Akhmadovich , Shaker  Shafik Shafik , Al-Gazally Moaed Emran , Ansari Mohammad Javed , Kandeel Mahmoud , Mustafa Yasser Fakri , Farhood Bagher 
Published: November 2022

Background:
Although radiotherapy is one of the main cancer treatment modalities, exposing
healthy organs/tissues to ionizing radiation during treatment can lead to different adverse effects.
In this regard, it has been shown that the use of radioprotective agents may alleviate the ionizing
radiation-induced toxicities.

Objective:
The present study aims to review the radioprotective potentials of silymarin/silibinin in
the prevention/reduction of ionizing radiation-induced adverse effects on healthy cells/tissues.

Methods:
Based on PRISMA guidelines, a comprehensive and systematic search was performed
for identifying relevant literature on the “potential protective role of silymarin/silibinin in the treatment
of radiotherapy-induced toxicities” in the different electronic databases of Web of Science,
PubMed, and Scopus up to April 2022. Four hundred and fifty-five articles were obtained and
screened in accordance with the inclusion and exclusion criteria of the current study. Finally, 19 papers
were included in this systematic review.

Results:
The findings revealed that the ionizing radiation-treated groups had reduced survival rates
and body weight in comparison with the control groups. It was also found that radiation can induce
mild to severe adverse effects on the skin, digestive, hematologic, lymphatic, respiratory, reproductive,
and urinary systems. Nevertheless, the administration of silymarin/silibinin could mitigate the
ionizing radiation-induced adverse effects in most cases. This herbal agent exerts its radioprotective
effects through anti-oxidant, anti-apoptosis, anti-inflammatory activities, and other mechanisms.

Conclusion:
The results of the current systematic review showed that co-treatment of silymarin/silibinin
with radiotherapy alleviates the radiotherapy-induced adverse effects in healthy cells/tissues.
Exploring the Phosphatidylcholine in Inflammatory Bowel Disease: Potential
Mechanisms and Therapeutic Interventions
Authors: Cui Bota , Ai Rujun , Xu Jie , Ji Guozhong 
Published: November 2022

Background:
Inflammatory bowel disease (IBD) is a significant health problem with an increasing financial burden worldwide. Although various treatment strategies have been used, the results were not satisfactory. More and more researches have proved that the application of phosphatidylcholine (PC) may become an alternative therapy for IBD.

Objective:
This review aims to provide an overview of the possible mechanisms of PC and promote the potential application of PC for IBD therapy further.

Methods:
A comprehensive literature search was performed in PubMed with the following keywords: ‘phosphatidylcholine’, ‘inflammatory bowel disease’, ‘Crohn's disease’, ‘inflammation’, ‘ulcerative colitis’, ‘therapy’, ‘nanomedicines’, ‘PKCζ’, ‘lysophosphatidylcholine’, ‘microbiota’ and ‘drug carrier’. The logical operators
“AND” and “OR” were applied to combine different sets of the search results.

Results:
Studies suggested that PC displays a significant effect in the treatment of IBD by modulating gut barrier function, remodeling gut microbiota structure, regulating polarization of macrophages, and reducing the inflammatory response. PC has also been exploited as a drug carrier for anticancer or anti-inflammation agents in
multiple forms, which implies that PC has immense potential for IBD therapy.

Conclusion:
PC has shown promising potential as a new therapeutic agent or a drug carrier, with a novel, stable, prolonged mechanism of action in treating IBD. However, more high-quality basic and clinical studies are
needed to confirm this.
Applications of Transesterification in the Synthesis of Commercial and Noncommercial
β -Ketoesters/Esters, Medicinally Important Heterocycles and Production of
Biodiesel
Authors: Bendi Anjaneyulu , Rao G.B. Dharma 
Published: November 2022

Abstract:
Transesterification is one of the paramount chemical reactions in organic synthesis
and is broadly used to synthesize the biologically and pharmacologically active heterocycles
of greater medicinal importance. The transesterification reaction provides the useful synthon
called β-ketoester, which bears both electrophilic and nucleophilic reactive centers, which is
helpful for the construction of various complex structures with greater medicinal properties.
This article discusses various methods to synthesize β-keto esters/esters via transesterification
through catalysis, including nanocatalysts, and different applications of transesterification
reactions in the preparation of biologically active heterocycles and production of biodiesel
have also been summarized as per the available literature. The main focus of the current study
is to highlight the importance of transesterification in synthesizing variety of commercial and noncommercial β -
ketoesters / esters, which will be used to synthesize various biologically important heterocycles and production of
biodiesel.
Potential of Surface Functionalized Nanomaterials in Innovative Drug
Development: A Mini-review
Authors: Ditta Sarwar Allah , Yaqub Atif , Tanvir Fouzia 
Published: November 2022

Abstract:
The unique properties of nanomaterials (NMs) make them special entities for biomedical innovation and research. Early diagnosis and follow-up of diseases are easily possible with the help of nanotechnology and nanomedicine, which can help combat any medical condition. Surface functionalization
with specific molecules might impart marked properties to NMs, leading to the modification of cellspecific interactions within the biological systems. This modification may provide excellent phenomena
for innovative drug development. Modified NMs might play essential roles in various applications, i.e., in
vivo diagnostics, magnetic resonance imaging (MRI), positron emission tomography (PET), etc. Functionalization of NMs with appropriate ligands, small molecules, or polymers assigned them enhanced
stability, biocompatibility, and functionality for their novel and improved biological applications. Surface
functionalized NMs might display enhanced antimicrobial, antidiabetic, and drug delivery potential for
various applications. Different studies reported the potential of functionalized metallic nanoparticles in
regenerative medicines. Conjugation of NMs with various molecules such as peptides, small ligands,
polysaccharides, proteins, saturated and polyunsaturated fatty acids, siRNA, plasmids, and DNA, might
be achieved by various reactions. Biomolecule-conjugated nanoparticles result in the production of hybrid
NMs with specific and novel biological interactions in biological systems. Chemical treatment methods
are considered among the most trusted and efficient functionalization methods. Some commonly used
techniques and strategies of functionalization involve grafting to and grafting from methods, ligand exchange technique, covalent bonding, chemisorption, non-covalent interactions, electrostatic adsorption,
etc. This brief review is dedicated to the surface functionalization of NMs with the latest development
Foot Functional Disability in Rheumatoid Arthritis: The Involvement of
Body Mass Index
Authors: Boussaid Soumaya , Jeriri Sarra , Hannech Emna , Rekik Sonia , Jammali Samia , Cheour Elhem , Sahli Hela , Elleuch Mohamed 
Published: November 2022

Introduction:
Overweight and obesity are common in patients with Rheumatoid Arthritis (RA), with a probable impact on bearing foot joints.

Aim:
Our study aimed to explore the impact of Body Mass Index (BMI) on foot health parameters in RA patients.

Methods:
It was a cross-sectional study. Domains of foot health explored were: foot pain (Numeric Rating Scale), foot-related activity limitations (Foot Function Index (FFI), and WOMAC scale), foot synovitis, foot deformity (Platto Score (PS)), radiological joint damage and footwear problems.

Results:
Fifty RA were included, 82% were female. The mean age was 45.68 ± 10.3 years. The mean DAS28-CRP was 3.25 ± 0.98. Sixty-six percent were overweight or obese, with a mean BMI of 29 Kg/m2 ± 5.74. The average foot pain intensity while walking was 6 ± 1.75. The mean swollen foot joint was 2.2 ± 1.55. The average foot structural index was 7.8 ± 2.73. The mean FFI Disability score was 32 ± 14.2 and WOMAC score was 33.8 ± 13.98. Half of our patients had footwear prob-lems predominantly because of claw toe (40%). High BMI was significantly correlated with foot pain and foot-related activity limitations. It was also correlated with foot deformities assessed with PS (B=4.78; CI(3.87-5.68); p = 0.02), foot synovitis (OR=4.66, CI(2.61-8.32); p < 0.001) and prob-lems with footwear (OR= 0.32; CI(0.18-0.56); p = 0.05). However, it was significantly associated with less radiological joint damage (CI(-0.7-1.1); p = 0.01) and lower foot sharp score (B = -13.9; CI(-0.34-0.01); P = 0.06).

Conclusion:
Despite our findings of a possible protective effect of obesity on structural damage, obesity is still an important cause of increased pain, functional disability, and impaired QoL in RA patients.
Expediting Molecular Translational Approach of Mesenchymal Stem Cells
in COVID-19 Treatment
Authors: Balaji Easwaran Vignesh , Satarker Sairaj , V Gujaran Tanvi , John Jeena , Veedu Anuranjana Putiya , George Krupa Thankam , Purayil Divya Kunhi , Beegum Fathima , Mathew Anna , Vibhavari RJA , Chaudhari Sneha Sunil , Pai K Sreedhara Ranganath 
Published: November 2022

Abstract:
Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 with severe respiratory failure and organ damage that later appeared as a pandemic disease. Worldwide, people’s mental and physical health and socioeconomic have been affected. Currently, with no promising treatment for COVID-19, the existing anti-viral drugs and vaccines are the only hope to boost the host immune system to reduce morbidity and mortality rate. Unfortunately, several reports show that people who are partially or fully vaccinated are still susceptible to COVID-19 infection. Evidence suggests that COVID-19 immunopathology may include dysregulation of macrophages and monocytes, reduced type 1 interferons (IFN-1), and enhanced cytokine storm that results in hypersecretion of proinflammatory cytokines, capillary leak syndrome, intravascular coagulation, and acute respiratory distress syndrome (ARDS) ultimately leading to the worsening of patient’s condition and death in most cases. The recent use of cell-based therapies such as mesenchymal stem cells (MSCs) for critically ill COVID-19 patients has been authorized by the Food and Drug Administration (FDA) to alleviate cytokine release syndrome. It protects the alveolar epithelial cells by promoting immunomodulatory action and secreting therapeutic exosomes to improve lung function and attenuate respiratory failure. As a result, multiple clinical trials have been registered using MSCs that aim to use various cell sources, and dosages to promote safety and efficacy against COVID-19 infection. In this review, the possibility of using MSCs in COVID-19 treatment and its associated challenges in their use have been briefly discussed.
The Experience of our Center in Patients Undergoing Insulin Degludec/
Insulin Aspart Co-formulation Therapy
Authors: Altay Feride Pınar , Farzaliyeva Aydan , İyidir Özlem Turhan , Bozkuş Yusuf , Kırnap Nazlı Gülsoy , Kut Altuğ , Nar Aslı , Tütüncü Neslihan Başçıl 
Published: November 2022

Aim:
A co-formulation containing insulin degludec and insulin aspart (IDegAsp) is available
for the treatment of diabetes in Turkey. We aimed to evaluate the clinical results of switching to
IDegAsp treatment for Type 2 diabetes.

Method:
A total of 217 patients with type 2 diabetes treated with IDegAsp and having follow-up data were included. The patients were divided into 3 groups. Group 1 switched from basal insulin to IDegAsp, group 2 switched from twice-daily premixed insulin regimen to IdegAsp, and group 3 switched from intensive and thrice-daily premixed insulin regimen to IDegAsp. Groups were evaluated in terms of changes in insulin dose, the number of injections, and changes in HbA1c.

Results:
The mean follow-up period was 7.5 ± 4.4 months. The mean age was 62.8 ± 12.9 years. The
mean duration of diabetes was 15.3 ± 8 years. There was a significant decrease in HbA1c and glucose
(p < 0.0001 and p < 0.0001, respectively). HbA1c was significantly reduced in group 1 (p < 0.0001)
while insulin dose and the number of injections increased (p < 0.0001 and p < 0.0001, respectively).
HbA1c, insulin dose, and the number of injections in group 2 and group 3 (p = 0.001, p = 0.002, p <
0.0001, respectively, and p < 0.0001, p = 0.043, p < 0.0001, respectively) were significantly reduced.

Conclusion:
This study includes real-life experiences involving a remarkable number of patients in
the literature. IDegAsp treatment provided effective blood glucose regulation and caused a significant
decrease in the insulin dose and the number of injections, resulting in increased quality of life
among those who had to receive twice or more insulin injections.
Recent Research on Medical Stent Manufacturing Based on 3D Printing
Technology
Authors: Lu Zikang , Xie Baocheng 
Published: November 2022

Background:
With the increasing number of patients with cardiovascular and respiratory
diseases, medical stents are needed to reshape the blood vessels and trachea to restore their function.
Due to its high degree of standardization, the existing medical stent manufacturing technology
is mature and suitable for most groups. However, conventional medical stents are not suitable for
every patient due to the patients’ individual differences and other reasons. Hence, patients need
custom medical stents. Therefore, 3D printing technology with high customization function as an
emerging stent manufacturing method has attracted much attention in recent years.

Objective:
By solving the problem of poor matching rates between traditional medical stents and
human body channels, 3D printing technology will continue to develop in the medical stent manufacturing
field.

Methods:
This study traces the representative patents related to the vascular stent and tracheal stent
manufacturing based on 3D printing technology.

Results:
Through the analysis of numerous patents about 3D printed vascular stents and tracheal
stents, the reasons for the mismatched medical stent specifications and low efficiency are summarized.
The challenges in the development of 3D printing medical stents are discussed.

Conclusion:
Research on the 3D printing of medical stents is conducive to improving patients’
suitability and medical stent implantation and reducing the time cost. More patents will be invented
in the future.
Seismic Performance Assessment of the Historical Reggio Calabria Cathedral
Authors: Brandonisio Giuseppe , Naqash Muhammad Tayyab , Farsangi Ehsan Noroozinejad 
Published: November 2022

Background:
Italy's church buildings' cultural and architectural significance cannot be overstated.

Objective:
This paper addresses the seismic vulnerability of the cathedral located in Reggio Calabria, Italy. The analysis of this building is interesting as it was retrofitted after the destructive 1908 Messina-Reggio Calabria earthquake.

Methods:
The original design illustrating the static schemes and the considered actions of the church are described. Structural drawings of that time are also reported, which proved to be fundamental for the numerical modelling of the building. The issues and assumptions made during the modelling phase of the structure with the seismic actions are also illustrated. All the transverse and longitudinal frames were analysed using nonlinear analysis to evaluate the seismic capacity and vulnerability indicators in terms of accelerations and periods.

Results:
The results provided by the modal analysis are presented and discussed to highlight the global dynamic behaviour of the church.

Conclusion:
The seismic vulnerability indicators have been calculated by considering the seismic actions recommended by the current technical standards and concerning the 1975 Messina earthquake, which represents the most severe earthquake experienced by the church.