bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Spherical Self-reconfigurable Modular Robot Joint with Electromechanical Connector based on Vision-guided Docking
Authors: Song Jingzhou , Wang Yun , qin ziao , Kong Fanxu 
Published: August 2022

Abstract
With the development of robotics, more and more different types of robotic systems appear. Among them, the modular self-reconfigurable robot is a relatively cutting-edge robot with high research value. Modular self-reconfigurable robot is a robot system composed of several unit modules connected and capable of autonomous deformation and reconfiguration. Meta-module is the basic unit and the most important component of the modular self-reconfigurable robot. Each module has complete functions such as docking, perception, motion, and control. Compared with traditional robots, our modular robots have the characteristics of free docking, deformable reconfiguration, and can be changed into different configurations to adapt to different tasks in robot applications. In this paper, we propose a spherical self-reconfigurable robot modular joint with electromechanical connector. The robot joint has three degrees of freedom and can be used as a unit module of a self-reconfigurable robot system to form self-reconfigurable robots with different configurations. An electromechanical connector with a single degree of freedom is proposed for vision-guided docking and electromechanical connection. Finally, we manufacture a self-reconfigurable robot modular joint prototype, build an experimental platform, and conduct experimental testing and performance verification on the prototype. A series of experiments on dislocation tolerance, visual inspection positioning accuracy, and bearing capacity test were carried out on the prototype of the connector to verify the feasibility of the design. In addition, a vision-guided autonomous docking test was performed to verify the overall performance of the connector.
Identification of high-reliability regions of machine learning predictions in materials science using perovskite oxides as an example
Authors: askanazi evan , Grinberg Ilya , Lazar Emanuel 
Published: August 2022

Abstract
Progress in the application of machine learning (ML) methods to materials design is hindered by the lack of understanding of the reliability of ML predictions, in particular for the application of ML to small data sets often found in materials science. Using ML prediction of lattice parameter, formation energy and band gap of ABO3 perovskites as an example, we demonstrate that 1) similar to the composition-structure-property relationships, inclusion in the ML training data set of materials from classes with different chemical properties will not be beneficial and will decrease the accuracy of ML prediction; 2) Reliable results likely will be obtained by ML model for narrow classes of similar materials even in the case where the ML model will show large errors on the dataset consisting of several classes of materials, and 3) materials that satisfy all well-known chemical and physical principles that make a material physically reasonable are likely to be similar and show strong relationships between the properties of interest and the standard features used in ML. We also show that analysis of ML results by construction of a convex hull in features space that encloses accurately predicted systems can be used to identify high-reliability chemically similar regions and extract physical understanding. Our results indicate that the accuracy of ML prediction may be higher than previously appreciated for the regions in which the ML model interpolates the available data, and that inclusion of physically unreasonable systems is likely to decrease ML accuracy. Our work suggests that analysis of the error distributions of ML methods will be beneficial for the further development of the application of ML methods in material science.
Comparison of Pediatric Inflammatory Multisystem Syndrome temporarily-associated with SARS-CoV-2 and Kawasaki Disease: Results from a nationwide German registry 2020-2021
Authors: Hufnagel Markus , Armann Jakob , Jakob André , Doenhardt Maren , Diffloth Natalie , Hospach Anton , Schneider Dominik T , Trotter Andreas , Roessler Martin , Schmitt Jochen , Berner Reinhard , group PIMS-DGPI working 
Published: August 2022

Abstract
The connection between Pediatric Inflammatory Multisystem Syndrome (PIMS) and Kawasaki Disease (KD) is not yet fully understood. Using the same national registry, clinical features and outcome of children hospitalized in Germany, and Innsbruck (Austria) were compared. Reported to the registry were 395 PIMS and 69 KD hospitalized patients. Patient age in PIMS cases was higher than in KD cases (median 7 [IQR 4–11] vs. 3 [IQR 1–4] years). A majority of both PIMS and KD patients were male and without comorbidities. PIMS patients more frequently presented with organ dysfunction, with the gastrointestinal (80%), cardiovascular (74%), and respiratory (52%) systems being most commonly affected. By contrast, KD patients more often displayed dermatological (99% vs. 68%) and mucosal changes (94% vs. 64%), plus cervical lymph node swelling (51% vs. 34%). Intensive care admission (48% vs. 19%), pulmonary support (32% vs. 10%), and use of inotropes/vasodilators (28% vs. 3%) were higher among PIMS cases. No patients died. Upon patient discharge, potentially irreversible sequelae – mainly cardiovascular – were reported (7% PIMS vs. 12% KD). Despite differences in age distribution and disease severity, PIMS and KD cases shared many common clinical and prognostic characteristics. This supports the hypothesis that the two entities represent a syndrome continuum.
Prospects for public involvement in monitoring the post-2020 global biodiversity framework
Authors: Danielsen Finn , Ali Natasha , Andrianandrasana Herizo , Baquero Andrea , Basilius Umai , Constantino Pedro , Frederiksen Per Ole , Isaac Max , Jakobsen PâviâraK , Klimmek Helen , Mapendembe Abisha , Meng Han , Moul Katherine , Oliva Maria , Schmidt-Vogt Dietrich , Sophat Seak , Sulyandziga Rodion , Burgess Neil 
Published: August 2022

Abstract
The world’s countries are negotiating a post-2020 global biodiversity framework to guide biodiversity actions by governments and other actors. We assessed monitoring possibilities, ranging from scientist-driven to those undertaken by local people, for the current proposed indicators to measure progress towards goals and targets in this framework. Of the 291 indicators, 159 (55%) require monitoring by scientists, whereas 132 (45%) can involve citizens. Contrary to expectations, the potential for citizen participation is lower than for the Aichi Targets. Involving citizens and Indigenous Peoples in the collection and interpretation of environmental data can support monitoring of progress and improve conservation outcomes, as demonstrated by global community monitoring and citizen science.
Separation and identification of related substances in Candesartan cilexetil tablets by UHPLC-Q- TOF-MS
Authors: Yang Lishi , Gu Xiao , Yan Chenxiao , Tao Qiaofeng , Zhao Xinyu , Hong Liya , Zheng Jinqi 
Published: August 2022

Abstract
Related substances, such as process-related substances and degradation products, may affect the efficacy of drugs and cause adverse reactions. Therefore, identifying and controlling them is of the importance. A rapid ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) method has been developed for the separation and characterization of related substances in Candesartan cilexetil tablets. Chromatographic separation was achieved by using ZORBAX Eclipse XDB-C18 column (2.1 mm× 100 mm, 1.8 µm), with two mobile phases consisting of acetonitrile/water (57:43, v/v) (including 0.1% formic acid) as solvent A and acetonitrile/water (90:10, v/v) (including 0.1% formic acid) as solvent B in a gradient mode of elution. This method is applied to the separation of related substances in commercial tablets obtained from two companies. Moreover, accelerated stability studies (60℃, 90% RH and 4500lx for ten days) and forced degradation studies (acidic, alkaline, oxidative and photolytic degradation conditions) were conducted as described in ICH Q1. A total of eleven related substances (including one process-related impurity and ten degradation products) were detected. The related substances were characterized through Q-TOF fragmentation studies, and their fragmentation pathways were proposed. Among them, four related substances have not been reported in the literature yet, and one of them (RS7) was further confirmed by reference substance. In addition, plausible mechanisms for the formation of these related substances are discussed.
Effective re-vascularization of non-healing wounds by the Stromal Vascular Fraction relies on the formation of hybrid vessels between host and transplanted cells.
Authors: Zacchigna Serena , Vuerich Roman , Groppa Elena , Vodret Simone , Ring Nadja , Cauteruccio Matteo , Colliva Andrea , Simoncello Francesca , Benvenuti Federica , Stocco Chiara , Bossi Fleur , Agostinis Chiara , Agnelli Anna , Dore Franca , Palmisano Silvia , De Manzini Nicolo' , Bulla Roberta , Papa Giovanni , Mazzarol Flavia , Moretti Massimo , Paulitti Alice , Chiesa Mattia , Pompilio Giulio 
Published: August 2022

Abstract
With the increased prevalence of chronic diseases, non-healing wounds place a significant burden on both the quality of life of affected patients and health systems. Skin substitutes are applied to promote the closure of non-healing wounds, although their efficacy is limited by inadequate vascularization. The stromal vascular fraction (SVF) from the adipose tissue has emerged as a promising therapy to overcome this limitation. Despite a few successful clinical trials, its incorporation in the clinical routine has been hampered by their inconsistent results. All these studies concluded by warranting pre-clinical work aimed at both characterizing the cell types composing the SVF and shedding light on their mechanism of action.
Here, we established a new model of non-healing wound, in which we applied the SVF in combination with a clinical grade skin substitute. First, we purified the SVF cells from transgenic animals to trace their fate after transplantation and observed that it gave rise to a mature vascular network composed of arteries, capillaries, veins, as well as lymphatics, structurally and functionally connected with the host circulation. Then we moved to a human-in-mouse model and confirmed that SVF-derived endothelial cells formed hybrid human-mouse vessels, that were stabilized by perivascular cells of both species. Also in this case, these vessels were connected with the host circulatory system and determined a 2-fold increase in tissue perfusion. Mechanistically, SVF-derived endothelial cells engrafted and expanded, directly contributing to the formation of new vessels, while a population of fibro-adipogenic progenitors stimulated the expansion of the host vasculature in a paracrine manner.
These data have important clinical implications, as they provide a steppingstone toward the reproducible and effective adoption of the SVF as a standard care for non-healing wounds.
The construction efficiency study of China National Ecological Civilization Pilot Zone with network SBM model: A city-based analysis
Authors: LIU Dan , LIU Tiange , ZHENG Yuting , ZHANG Qi 
Published: August 2022

Abstract
The Chinese government proposed the establishment of China National Ecological Civilization Pilot Zone in 2016 to further explore the coordinated development of economy and environment, and Fujian, Jiangxi and Guizhou provinces were selected as the first batch of pilot zones. After years of exploration, it is necessary to discuss and summarize the construction progress of the three pilot zones from the perspective of the city. In this study, first, the ecological civilization pilot zone construction system was decomposed into an economic construction subsystem (ECS) and an environmental optimization subsystem (EOS). Then, a two-stage network SBM model was adopted to calculate the efficiencies of the subsystems, and the Kruskal-Wallis test was used to measure the efficiency difference. Finally, a panel data regression model was applied to explore the influencing factors of both subsystems. The results show that the ECS efficiency is higher than that of the EOS, and the ECS efficiency in Fujian is significantly better than that in Jiangxi and Guizhou, however, there is no significant difference in EOS efficiency in the three provinces. Furthermore, industrial structure and population agglomeration have a significant effect on ECS efficiency, environmental regulation has a significant impact on EOS, and the technology level has a significant impact on both subsystems. Based on the results, policy implications for improving the efficiency of the two subsystems were given respectively.
BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms
Authors: Fry Andrew , Singh Anita , Busacca Sara , Gaba Aarti , Sheaff Michael , Poile Charlotte , Nakas Apostolos , Dzialo Joanna , Bzura Aleksandra , Dawson Alan , Fennell Dean 
Published: August 2022

Abstract
The tumour suppressor BRCA1-associated protein 1 (BAP1) is the most frequently mutated cancer gene in mesothelioma. Here we report novel functions for BAP1 in mitotic progression highlighting the relationship between BAP1 and control of genome stability in mesothelioma cells with therapeutic implications. Depletion of BAP1 protein induced proteasome-mediated degradation of BRCA1 in mesothelioma cells while loss of BAP1 correlated with BRCA1 loss in mesothelioma patient tumour samples. BAP1 loss also led to mitotic defects that phenocopied the loss of BRCA1 including spindle assembly checkpoint failure, centrosome amplification and chromosome segregation errors. However, loss of BAP1 also led to additional mitotic changes that were not observed upon BRCA1 loss, including an increase in spindle length and enhanced growth of astral microtubules. Intriguingly, these consequences could be explained by loss of expression of the KIF18A and KIF18B kinesin motors that occurred upon depletion of BAP1 but not BRCA1, as spindle and astral microtubule defects were rescued by re-expression of KIF18A and KIF18B, respectively. We therefore propose that BAP1 inactivation causes mitotic defects through BRCA1-dependent and independent mechanisms revealing novel routes by which mesothelioma cells lacking BAP1 may acquire genome instability and exhibit altered responses to microtubule-targeted agents.
Investigation of Sleep Quality and its influencing factors in Iranian Patients with Esophageal and Gastric Cancer
Authors: Maroufi Negin , Sohrabi Masoudreza , Mehrabadi Shima , Zamani Farhad , Ajdarkosh Hossein , Hatamian Sare , Bahavar Atefeh , Tameshkel Fahimeh Safarnezhad , Gholami Ali 
Published: August 2022

Abstract
Sleep quality is one of the noteworthy clinical constructs, which affect physical and mental health. The main approach of this study was to investigate sleep quality and its influencing factors among patients suffering from esophageal and gastric cancer. Pittsburg Sleep Quality Index (PSQI) was completed by 312 cancer patients aged from 18 to 93. Univariate and multivariable logistic regression was applied. The Results demonstrated that about 66% of cancer patients had poor sleep quality regardless of their cancer type and stage. Furthermore, Wealth Index (WI), chronic diseases, and marital status seemed to influence cancer patients' sleep quality. In conclusion, it may seem that paying more attention to these influencing factors will improve the sleep quality of cancer patients.
Monosodium glutamate (MSG) perturbs trophoblast differentiation and invasion program through a ROS mediated pathway
Authors: Mukherjee Indrani , Singh Sunil , Biswas Subhrajit , Talukdar Joyeeta , Alqahtani Mohammed S. , Abbas Mohamed , Nag Tapas Chandra , Mridha Asit , Gupta Surabhi , Sharma Jai Bhagwan , Kumari Supriya , Dhar Ruby , Karmakar Subhradip 
Published: August 2022

Abstract
Monosodium glutamate (MSG) is a flavor-enhancing food additive widely used in Asian cuisine. It is one of the common ingredients used in curry and other tinned food that is believed to bring out the "umami" meat flavor and enhance the savory taste of the food. It is the sodium salt of the naturally occurring amino acid Glutamate. Due to its massive consumption as part of fast-food culture along with concerns about its possible effect on health in general and pregnancy in particular, we undertook this study to address its impact on placental trophoblast cells. We investigated the effect of MSG on placental trophoblast cells. Our studies confirmed that short and long-term exposure to MSG has a profound influence on trophoblast invasion and differentiation, two of the most critical and dispensable functions during placentation. Our results showed an acute short-term MSG-treatment enhanced trophoblast invasion and cell motility along with an increased expression in trophoblast cell differentiation markers. However, a long-term chronic MSG stimulation in these cell types showed an opposite effect with both reduced invasion and differentiation. Further, MSG-treated placental explants displayed signs of an elevated oxidative stress. These effect of MSG on trophoblast cells along with an increased ROS production indicates that short and long-term usage of MSG as part of food additive might have adverse health consequences on the fetus by compromising the trophoblast and placental function.
“I realised that, if I am dead, I cannot finish my PhD!”: A narrative ethnography of psychological capital in academia
Authors: Pretorius Lynette 
Published: August 2022

Abstract

Despite the increasing quantitative evidence that there is a mental health crisis in doctoral education, there is a lack of qualitative research that highlights the voices of individuals experiencing mental illness. This study highlights the experiences of a second-year PhD student as she discovers that she is mentally unwell. The participant’s experiences are interwoven with the reflections and experiences of the researcher, a doctoral educator. Through the use of narrative ethnography, this study highlights the need for doctoral educators to build an environment that fosters students’ psychological capital by helping them develop efficacy, optimism, hope, and resilience. In this way, doctoral education environments can become more welcoming, compassionate, inclusive, and growth-focused. This study also demonstrates the benefits for educators of employing narrative ethnography as a methodology to improve their own pedagogical practices by better understanding their own lived experiences as well as those of their students.
Modeling the Antidepressant Treatment Response to Transcranial Magnetic Stimulation using an Exponential Decay Function
Authors: Berlow Yosef A. , Zandvakili Amin , Brennan McKenna C. , Williams Leanne M. , Price Lawrence H. , Philip Noah S. 
Published: August 2022

Abstract
Recovery from depression often demonstrates a nonlinear pattern of treatment response, where the largest reduction in symptoms is observed early followed by smaller improvements. This study investigated whether this exponential pattern could model the antidepressant response to repetitive transcranial magnetic stimulation (TMS). Symptom ratings from 97 patients treated with TMS for depression were collected at baseline and after every five sessions. A nonlinear mixed-effects model was constructed using an exponential decay function. This model was also applied to group-level data from several published clinical trials of TMS for treatment-resistant depression. These nonlinear models were compared to corresponding linear models. In our clinical sample, response to TMS was well modeled with the exponential decay function, yielding significant estimates for all parameters and demonstrating superior fit compared to a linear model. Similarly, when applied to multiple studies comparing TMS modalities as well as to previously identified treatment response trajectories, the exponential decay models yielded consistently better fits compared to linear models. These results demonstrate that the antidepressant response to TMS follows a nonlinear pattern of improvement that is well modeled with an exponential decay function. This modeling offers a simple and useful framework to inform clinical decisions and future studies.
Response of Canopy Photosynthesis, Grain Quality and Harvest Index of Wheat to Different Nitrogen Application Methods
Authors: Zhang Xiangqian , Du Shizhou , Xu Yunji , Qiao Yuqiang , Cao Chengfu , Li Wei 
Published: August 2022

Abstract
To fully explore the effects of N on enhancing photosynthesis, grain quality and yield of wheat, experiments with four nitrogen levels 0 (N0), 120 (N1), 180 (N2) and 240 (N3) kg N ha− 1 and four ratios of basal to topdressing R0 (0:0), R1 (7:3), R2 (6:4) and R3 (5:5) were conducted. The effect of N topdressing ratio on improving leaf area of photosynthetic efficiency was insignificant under the same N level. The effect of N fertilization level on increasing chlorophyll content was more significant than that of N topdressing ratio. Within the same N level, the canopy photosynthetically active radiation in R2 was higher than that in R1 and R3, and increasing 60 kg N ha− 1 significantly enhanced canopy photosynthetically active radiation. The effect of N topdressing ratio on photosynthetic rate, stomatal conductance and transpiration rate were consistently R2 > R3 > R1, compared to N1, N3 could significantly increase photosynthetic rate. Increasing 120 kg N ha− 1 significantly enhanced grain protein content, wet gluten and sedimentation value, while the effect of N topdressing ratio was insignificant. Increasing N application amount from 120 kg ha− 1 to 180 kg ha− 1 significantly enhanced yield, and the yields and harvest indexes in 2019, 2020 and 2021 were consistently R2 > R3 > R1. The findings suggested that the effect of increasing N application amount (60 kg ha− 1) was more obviously than that of N topdressing ratio, and R2 was more conducive to improving canopy photosynthesis, grain quality, yield and harvest index.