bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bioefficacy and persistence of acaricides applied against two spotted spider mite (Tetranychus urticae Koch) in cucumber (Cucumis sativus Linnaeus) under protected cultivation system
Authors: Prakash K. , Baskaran V. , Suganthi A. , Sumathi E. , Swarnapriya R. 
Published: June 2022

Abstract
The two-spotted spider mite (Tetranychus urticae Koch) is the most pronounced polyphagous non-insect pest, wreaking havoc on agricultural and horticultural crops. In cucumber, the infestation by various pests jeopardises effective cultivation, with two spotted spider mites causing great harm to the crop. Six different chemical acaricides were tested for their effectiveness against T. urticae in cucumber cultivated under protected cultivation system at the farmer’s field. The results revealed that none of the acaricides exhibited a tangible decrease over the control, but spiromesifen (59.50 %) recorded a rather excellent reduction over the other investigated chemicals (40 to 54.47 %). The experimental bioassays were performed to determine the effective dosage, which resulted in a significant mite population reduction and the results revealed that tested chemical acaricides were found to be effective at their higher dose, ranging nearly from 3X to 4X of recommended by CIB&RC. The pot culture and field study was conducted to determine the effectiveness of fixed doses from bioassay investigations. A good reduction in mite population was observed for all tested chemicals with spiromesifen recorded a 100 per cent reduction in mite population. Residue analysis of harvest time samples of cucumber after spiromesifen application revealed residues below quantification limit of 0.025 µg/kg.
Intracorporeal versus extracorporeal anastomosis in laparoscopic right colectomy: a retrospective study
Authors: Chen Fangqian , Lv Zeping , Feng Wenqing , Xu Zhuoqing , Miao Yiming , Xu Zifeng , Zhang Yuchen , Gao Han , Zheng Minhua , Zong Yaping , Zhao Jingkun , Lu Aiguo 
Published: June 2022

Abstract
Background: Laparoscopic right colectomy (LRC) with intracorporeal ileocolic anastomosis (IIA) may be beneficial for postoperative recovery, but there is a lack of evidence to confirm this hypothesis. This study aimed to investigate the feasibility and safety of IIA.Methods: A total of 114 patients who underwent LRC with IIA (58) or extracorporeal ileocolic anastomosis (EIA, 56) between January 2019 and September 2021 were enrolled. We assessed clinical characteristics, pathological characteristics and short-term outcomes.Results: Faster gastrointestinal (GI) recovery and less postoperative pain were observed in patients with IIA than EIA [time to first flatus: (2.4±0.7) vs (2.8±1.0) days, p <0.01; time to fluid intake: (3.5±0.7) vs (4.0±1.1) days, p =0.01; visual analogue scale score on the day of surgery: (3.9±1.0) vs (4.3±0.6), p =0.02]. No significant differences were detected in oncological outcomes or postoperative complications. IIA tended to be performed in patients with higher body mass index than EIA [( 23.93±3.52) vs ( 22.36±2.87) kg/m2, p =0.01].Conclusions: IIA is associated with faster GI function recovery and less postoperative pain, and considered to be potentially superior to EIA in patients with obesity.
Focus Fusion: Overview of Progress Towards p-B11 Fusion with the Dense Plasma Focus
Authors: Lerner Eric J. , Hassan Syed 
Published: June 2022

Abstract
LPPFusion is developing a source of fusion energy using the dense plasma focus device and pB11 fuel, a combination we call Focus Fusion. So far, this project has led to the achievement of the highest confined ion energies of any fusion experiment (> 200 keV) as well as, recently, the lowest impurities of any fusion plasma. Among privately-funded fusion efforts, our experiments have achieved the highest ratio of fusion energy generation to device energy input (wall-plug efficiency) and the highest ntT product of 3.4x1020 keV-s/cm3. Our calculations and simulations indicate that the quantum magnetic field effect will allow a great reduction in bremsstrahlung radiation with pB11 fuel. For commercial fusion, this approach has several major advantages. The small size and simplicity of design of the DPF can lead to 5MW generators that are much cheaper than any existing energy source, that can be manufactured by mass production and that can be located close to loads. It shares with other pB11 approaches a lack of neutron damage and radioactive waste. Direct energy conversion of the ion beam and x-rays produced by the device avoids the high costs associated with thermal cycles. With adequate, but still modest, financial resources we anticipate working prototype generators could be ready for production by 2026–2030.
Blood-brain-barrier dysfunction and folate and vitamin B12 levels in first-episode psychosis
Authors: Campana Mattia , Löhrs Lisa , Strauß Johanna , Münz Susanne , Oviedo-Salcedo Tatiana , Fernando Piyumi , Maurus Isabel , Raabe Florian , Moussiopoulou Joanna , Eichhorn Peter , Falkai Peter , Hasan Alkomiet , Wagner Elias 
Published: June 2022

Abstract
Background: Vitamin deficiency syndromes and blood-brain-barrier (BBB) dysfunction are frequent phenomena in psychiatric conditions. We analysed the largest available first-episode psychosis (FEP) cohort to date regarding routine cerebrospinal fluid (CSF) and blood parameters to investigate the association between vitamin deficiencies (vitamin B12 and folate) and BBB impairments in FEP. Methods: We report a retrospective analysis of clinical data from all inpatients that were admitted to our tertiary care hospital with an ICD-10 diagnosis of a first-episode F2x (schizophrenia-spectrum) between January 1, 2008 and August 1, 2018 and underwent a lumbar puncture and blood-based vitamin status diagnostics within the clinical routine. Results: 222 FEP patients were included in our analyses. We report an increased CSF/serum albumin quotient (Qalb) as a sign of BBB dysfunction in 17.1% (38/222) of patients. White matter lesions (WML) were present in 29.3% of patients (62/212). 17.6% of patients (39/222) showed either decreased vitamin B12 levels or decreased folate levels. No statistically significant association was found between impairments in vitamin levels and an altered Qalb.Conclusions: This retrospective analysis contributes to the discussion on the impact of vitamin deficiency syndromes in FEP. Although decreased vitamin B12 or folate levels were found in approximately 17% of our cohort, we found no evidence for significant associations between BBB dysfunction and vitamin deficiencies. To strengthen the evidence regarding the clinical implications of vitamin deficiencies in FEP, prospective studies with standardized measurements of vitamin levels together with follow-up measurements and assessment of symptom severity in addition to CSF diagnostics are needed.
Identification of new biomarkers for pancreatic cancer management: A bioinformatics analysis
Authors: Jafari Somayeh , Ravan Milad , Aria Hamid , Atapour Amir , Sarab Gholamreza Anani 
Published: June 2022

Abstract
Background
Pancreatic adenocarcinoma is one of the highly invasive and the seventh most common cause of death among cancers worldwide. To identify key genes and the involved mechanisms in pancreatic adenocarcinoma, we used bioinformatics analyzes in our study to introduce potential biomarkers in pancreatic cancer management.
Methods
In this study, gene expression profiles of pancreatic adenocarcinoma patients and normal adjacent tissues were screened and downloaded from The Cancer Genom Atlas (TCGA) bioinformatics database. Differentially expressed genes (DEGs) were identified between normal and pancreatic cancer gene expression signatures using R software. Then, Enrichment analysis of DEGs [including Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis] was performed by an enrichr (interactive and collaborative HTML5 gene list enrichment analysis) web-based tool. The protein-protein interaction (PPI) network was also constructed using STRING (Search Tool for the Retrieval of Interacting Genes) and Cytoscape software to identify the hub genes according to the top 100 DEGs in pancreatic adenocarcinoma.
Results
In our study, more than 2000 DEGs with variable log2 fold (LFC) were identified among 34,706 genes. Principal component analysis showed that the top 20 DEGs, including H1-4, H1-5, H4C3, H4C2, RN7SL2, RN7SL3, RN7SL4P, RN7SKP80, SCARNA12, SCARNA10, SCARNA5, SCARNA7, SCARNA6, SCARNA21, SCARNA9, SCARNA13, SNORA73B, SNORA53, SNORA54 with 99.91% probability might distinguish pancreatic adenocarcinoma from normal tissue. GO analysis of these 20 top DEGs showed that they have more enriched in negative regulation of gene silencing, negative regulation of chromatin organization, negative regulation of chromatin silencing, nucleosome positioning, regulation of chromatin silencing and nucleosomal DNA binding. KEGG analysis identified an association between pancreatic adenocarcinoma and systemic lupus erythematosus, alcoholism, neutrophil extracellular trap formation, and viral carcinogenesis. In protein-protein interaction (PPI) network analysis, we found that different types of histone-encoding genes are involved as hub genes in the carcinogenesis of pancreatic adenocarcinoma.
Conclusions
Our bioinformatics analysis showed that the DEGs and hub genes as key genes identified in this study may serve as new biomarkers in the near future for better management of pancreatic cancer. Although, H1.3 is currently one of the prognostic biomarkers in pancreatic cancer.
Anti-nodavirus potential activity of R.A73 Enterococcus faecium strain, isolated from Tunisian freshwater fish mucus
Authors: Chérif Nadia , El-Jeni Rim , Amdouni Fatma , Bouhaouala-Zahar Balkiss , El-Bour Monia 
Published: June 2022

Abstract
R.A73 Enterococcus faecium (HG937697) was tested for investigating anti-nodaviral activity and immunomodulatory properties on E-11 fish cells. Non R.A73-related toxicity was confirmed. Likewise, in-vitro inhibition of nodavirus replication and gene expression of nodavirus capsid protein gene in addition to CCR3, IL-10 and TNFα genes were evaluated using qPCR. A preventive treatment of E-11 cells by the bacterial suspension generated a remarkable reduction in virus loads (RQ values from 0.1 to 0.9) at day 7. Interestingly, R.A73 E. faecium showed a significant gene expression upregulation of proinflammatory IL-10 cytokine whereas it did not significantly enhance CCR3 nor TNF-α immune gene expression in E-11 cells. Therefore, add-on its probiotic potential, R.A73 E. faecium is able to stimulate the immune system in the preventive phase throughout the differential expression of main inflammatory genes. This study provides the first evidence that R.A73 E. faecium strain can prevents effectively nodavirus replication, in vitro.
Application of Protein-Protein interaction network analysis in order to identify Cervical cancer mRNA and miRNA biomarkers
Authors: Tabrizi-Nezhadi Parinaz , MotieGhader Habib , Maleki Masoud 
Published: June 2022

Abstract
Background: Cervical cancer (CC) is one of the most common and serious cancers in the world. This cancer includes two histological types including Squamous cell carcinoma (SCC) and adenocarcinoma (ADC). In this project SCC have been studied. The current study aimed to identify novel potential candidate mRNA and miRNA biomarkers for CC based on a Protein-Protein Interaction (PPI) and miRNA-mRNA networks analysis.Results: In the current project, transcriptome profile for normal and CC samples was utilized. First, the PPI network was constructed for the 1335 DEGs, and then a significant gene module was extracted from the PPI network. Next, a list of miRNAs which are targeting module's genes are collected from the miRTarBase online database and a miRNA-mRNA regulatory network was formed. Afterward, CC driver genes were selected from the module's genes (MCM2, MCM10, POLA1, and TONSL) and introduced as potential candidate biomarkers for CC. As well as, two hub miRNAs including miR-193b-3p and miR-615-3p were selected from the miRNA-mRNA regulatory network and reported as potential candidate biomarkers for CC. Conclusion: In summary, six potential candidate RNA-based biomarkers consist of four genes containing MCM2, MCM10, POLA1, and TONSL and two miRNAs containing miR-193b-3p and miR-615-3p are opposed as potential candidate biomarker for CC.
Autonomous Vehicle Decision-Making at Unsignalized Intersection via Deep Reinforcement Learning
Authors: Xie Junran , Wang Qingling 
Published: June 2022

Abstract
This paper is concerned with the performance of different state representation on the vehicle decision-making problem at unsignalized intersection based on deep reinforcement learning. A hybrid state representation architecture based on attention mechanism and collision time prediction is designed, which can effectively improve the autonomous decision-making ability of vehicles. Compared with the traditional state representation method, the feature of our method is that the fusion of features can improve the vehicle’s obstacle avoidance ability, and the introduced action masking module can improve the vehicle’s traffic efficiency. Finally, test results in the simulation environment verify the effectiveness of our proposed method.
Student Perspectives on the Use of Universal Design for Learning in Virtual Formats in Higher Education
Authors: Wells Melissa 
Published: June 2022

Abstract
Universal Design for Learning (UDL) in higher education may be a useful tool in supporting the heterogenous higher education student population, specifically in supporting student academic outcomes and retention. With more students enrolling in digital formatted education, specifically international students, a strong framework must be established to support non-geocentric students. Using survey responses of undergraduate degree-seeking students, this mixed-methods study explored the students’ perceptions and impact of UDL in virtual learning modalities (online courses, independent studies, and virtual study groups). Participants used a Likert-type survey to assess the student-reported prevalence of UDL techniques in higher education in various virtual learning modalities. Students also discussed the strategies that impacted their experience as learners and the mode of study in which they felt most successful. Implications for practice and research are also presented.
CoFee-L: A model of animal displacement in large groups combining Cohesion maintenance, Feeding area search and transient Leadership.
Authors: Gavrilitchenko Nikita , Gazagne Eva , Vandewalle Nicolas , Delcourt Johann , Hambuckers Alain 
Published: June 2022

Abstract
BackgroundIn the current context of climate change and intensive anthropization of natural environments, the preservation of ecosystems is a matter of great importance. In the tropics, the conservation of tree species is closely linked to that of animals. A large proportion of tree species is zoochore and needs animals, mainly vertebrates, to disperse their seeds in order to increase their chances of survival. Being able to predict the movement of animals is therefore an important skill. Lots of research exists on the subject, but it has always focused on particular characteristics of collective behavior. In contrast to previous studies, we included the concepts of Cohesion maintenance, Feeding area search and transient Leadership in a single model, CoFee-L.MethodsWe tested CoFee-L to simulate the movement of a wild-ranging troop of primates belonging to the species Macaca leonina in a nature reserve of Thailand. We analyzed this methodology by statistical physics tools (mean squared displacement) and we characterized the simulated trajectories by histograms and χ2 for the step length and turning angle distributions sampled at the same frequency as the collection of field observations.ResultsCoFee-L allowed us to reproduce the physical properties of the troop's centre of mass trajectory, as well as the step length and angle distributions of the field data. Moreover, CoFee-L is able to produce trajectories looking like correlated random walks or levy walks depending of the parametrisation. ConclusionsWe created a model, CoFee-L, which allowed us to simulate the movement of a group of vertebrates taking into account not only the movement and individual characteristics of each member, but this also independently of the group size. The parameterisation of CoFee-L was rather simple, as it was sufficient to fix a set of parameters easily observable in the field (number of individuals, size of the study site, duration of monitoring, duration of foraging, distance between individuals and maximum spread of the group) and then to adjust the values of 4 parameters which have biological meaning (personal information, exploration of the study site, speed of movement and tendency to do a levy walk).
Clinical verification of the relationship between serum lipid metabolism and immune activity in breast cancer patients treated with neoadjuvant chemotherapy
Authors: Goto Wataru , Kashiwagi Shinichiro , Takada Koji , Asano Yuka , Ogisawa Kana , Morisaki Tamami , Shibutani Masatsune , Tanaka Hiroaki , Ohira Masaichi 
Published: June 2022

Abstract
Background: The have been recent reports that lipid metabolism affects the prognosis and tumor immune activity in cancer patients. However, the effect of lipid metabolism on chemosensitivity in patients with breast cancer treated with neoadjuvant chemotherapy (NAC) remains unclear. Methods: We examined 327 patients with breast cancer who were treated with NAC followed by curative surgery. The correlations between the serum levels of total cholesterol (TC) and triglyceride (TG) and the clinicopathological features, including the efficacy of NAC, neutrophil-to-lymphocyte ratio (NLR), and absolute lymphocyte count (ALC), were evaluated retrospectively. Results: Serum TG levels were increased after NAC in all the subtypes, and the rate of change was the highest, especially in triple-negative breast cancer (TNBC) (21.0% → 48.1%). In addition, only TNBC patients with an objective response (OR) had significantly higher TG levels after NAC than those without (P = 0.049). Patients with a high ALC before NAC had significantly higher TG levels after NAC than patients with breast cancer (P = 0.001), HER2-enriched breast cancer (P = 0.021), and TNBC (P = 0.008). Patients with a low NLR before NAC had significantly higher TG levels after NAC only among patients with TNBC (P = 0.025). In patients with human epidermal growth factor receptor 2-enriched breast cancer, the group with normal TC levels before NAC had significantly better OS than those with high TC levels (P = 0.013, log-rank test), and in patients with TNBC, the group with high TC levels after NAC had significantly better OS than those with normal TC levels (P = 0.014, log-rank test). Conclusions: Good systemic immune activity and chemosensitivity may be associated with lipid metabolism regulated by NAC in TNBC patients.
Hub genes for early diagnosis and therapy of adamantinomatous craniopharyngioma
Authors: Zou Yang-fan , Zhang Shu-yuan , Wu Bin , Li Li-weng , Jin Kai , Sun Caixing , Xia Liang 
Published: June 2022

Abstract
Background: Adamantinomatous craniopharyngioma (ACP) is a subtype of craniopharyngioma which is a neoplastic disease with a benign pathological phenotype but a poor prognosis in the sellar region. The disease has been considered as the most common congenital tumor in the skull. Therefore, the purpose of this article is to identify hub genes which might serve as genetic markers of diagnosis, treatment and prognosis of ACP.Methods: The procedure of this research includes acquisition of public data, identification and functional annotation of differentially expressed genes (DEGs), construction and analysis of PPI network, and the mining and analysis of hub genes by Spearman-rho test, multivariable linear regression, and receiver operator characteristic curve analysis. Quantitative real-time (RT-qPCR) were used to detect the level of mRNA of relative genes.Results: Among 2 datasets, a total of 703 DEGs were identified, which were mainly enriched in chemical synaptic transmission, cell adhesion, odontogenesis of dentin-containing tooth, cell junction, extracellular region, extracellular space, structural molecule activity, and structural constituent of cytoskeleton. The PPI network was composed of 4379 edges and 589 nodes. Its significant module had 10 hub genes, and SYN1, SYP and GRIA2 were significantly down-regulated with ACP.Conclusion: In a word, we find out the DEGs between ACP patients and normal samples, which are likely to play an important role in the development of the ACP. At the same time, these DEGs are of great value in the diagnosis and targeted therapy of tumors, and could even be mined as biological molecular targets for the diagnosis and therapy of ACP patients.
Snack consumption patterns and their associations with risk of incident metabolic syndrome: Tehran Lipid and Glucose Study
Authors: Gaeini Zahra , Malmir Hanieh , Mirmiran Parvin , Feizy Zahra , Azizi Fereidoun 
Published: June 2022

Abstract
Aim: Few studies considered the association between snack patterns and metabolic abnormalities. Here we aimed to characterize the major snack patterns among Iranian adults and determine their association with the risk of metabolic syndrome (MetS) and its components.Methods: This study was conducted on 1713 MetS-free adults who participated in the third phase of the Tehran Lipid and Glucose Study (TLGS). At baseline, dietary intake of snack was assessed using a validated 168-items food frequency questionnaire, and snack patterns were obtained by principal component analysis (PCA). Adjusted Hazard Ratios (HRs) and 95% confidence intervals (CIs) were calculated for the association of incident MetS and its components with the extracted snack patterns.Results: PCA identified five major snack patterns, defined as "healthy pattern", "low-fructose pattern", "high-trans pattern", "high-caffeine pattern" and "high-fructose pattern". Participants in the highest tertile of the "high-caffeine pattern" had lower risks of MetS (HR=0.80, 95% CI=0.65-0.99) and hypertriglyceridemia (HR=0.76, 95% CI=0.63-0.92). The risk of developing abdominal obesity and hypertension decreased by 27% and 24%, respectively, in the highest compared to the lowest tertile of the "low-fructose pattern" (HR=0.73, 95% CI=0.61-0.88 and HR=0.76, 95% CI=0.58-0.99, respectively). Other snack patterns have not shown any significant association with MetS and its components.Conclusions: "High-caffeine pattern" was associated with lower risks of MetS and hypertriglyceridemia. In addition, greater adherence to a "low-fructose pattern" resulted in reduced abdominal obesity and hypertension risks.