bluuebunny/crossref_metadata_2025_split huggingface dataset:
Luteinizing hormone stimulates the expression of amphiregulin in human theca cells
Authors: Liu Yang , Zhong Yiping , Shen Xiaoting , Guo Xi , Wu Rihan , Yang Turui , Chen Minghui 
Published: December 2022

Abstract
Background
Luteinizing hormone (LH) can stimulate mural granulosa cells to produce Amphiregulin (AREG), which can induce the resumption of meiosis in oocytes. Theca cells are present in the outer layer of follicles, providing communication with the pituitary axis through the established vascular system around the follicle. As LH target cells, it is unknown whether theca cells can produce AREG after LH stimulation.

Methods
Primary cultured human theca cells were treated with LH (with or without the inhibitor of PKA, H89), or agonists of adenylate cyclase (forskolin or db-cAMP). The mRNA and protein levels of AREG were evaluated by RT-qPCR, immunochemistry, immunofluorescence, western blotting, and ELISA.

Results
Immunohistochemistry of normal ovarian tissue obtained in the early-mid follicle phase showed that AREG expression was absent in both the theca layer and the granulosa cell layer of antral follicles. Double immunofluorescent staining revealed colocalization of AREG and CYP17A1 in human theca cells and colocalization of FSHR and AREG in human granulosa cells isolated from follicular fluid collected during IVF/ICSI after hCG trigger. LH significantly increased the mRNA and protein levels of AREG in human theca cells and the concentration of AREG in the culture medium. Forskolin and db-cAMP, activators of the cAMP/PKA signalling pathway, also significantly increased the mRNA and protein levels of AREG in human theca cells and the concentration of AREG in the culture medium. H89 antagonized the stimulating effect of LH on AREG expression in human theca cells. In addition, the concentration of AREG was lower in polycystic ovarian syndrome (PCOS) follicular fluid than in normal follicular fluid. The mRNA levels of AREG were significantly lower in PCOS granulosa cells and theca cells than in normal granulosa cells and theca cells.

Conclusion
LH can stimulate the expression of AREG in human theca cells, and the adenylate cyclase/cAMP/PKA cascade may mediate this process. Expression of AREG is decreased in PCOS theca cells compared to normal theca cells, with or without LH stimulation.
Maintenance of gut microbiome stability for optimum intestinal health in pigs – a review
Authors: Upadhaya Santi Devi , Kim In Ho 
Published: December 2022

AbstractPigs are exposed to various challenges such as weaning, environmental stressors, unhealthy diet, diseases and infections during their lifetime which adversely affects the gut microbiome. The inability of the pig microbiome to return to the pre-challenge baseline may lead to dysbiosis resulting in the outbreak of diseases. Therefore, the maintenance of gut microbiome diversity, robustness and stability has been influential for optimum intestinal health after perturbations. Nowadays human and animal researches have focused on more holistic approaches to obtain a robust gut microbiota that provides protection against pathogens and improves the digestive physiology and the immune system. In this review, we present an overview of the swine gut microbiota, factors affecting the gut microbiome and the importance of microbial stability in promoting optimal intestinal health. Additionally, we discussed the current understanding of nutritional interventions using fibers and pre/probiotics supplementation as non-antibiotic alternatives to maintain microbiota resilience to replace diminished species.
Targeting toll-like receptor 7/8 for immunotherapy: recent advances and prospectives
Authors: Sun Hao , Li Yingmei , Zhang Peng , Xing Haizhou , Zhao Song , Song Yongping , Wan Dingming , Yu Jifeng 
Published: December 2022

AbstractToll-like receptors (TLRs) are a large family of proteins that are expressed in immune cells and various tumor cells. TLR7/8 are located in the intracellular endosomes, participate in tumor immune surveillance and play different roles in tumor growth. Activation of TLRs 7 and 8 triggers induction of a Th1 type innate immune response in the highly sophisticated process of innate immunity signaling with the recent research advances involving the small molecule activation of TLR 7 and 8. The wide range of expression and clinical significance of TLR7/TLR8 in different kinds of cancers have been extensively explored. TLR7/TLR8 can be used as novel diagnostic biomarkers, progression and prognostic indicators, and immunotherapeutic targets for various tumors. Although the mechanism of action of TLR7/8 in cancer immunotherapy is still incomplete, TLRs on T cells are involved in the regulation of T cell function and serve as co-stimulatory molecules and activate T cell immunity. TLR agonists can activate T cell-mediated antitumor responses with both innate and adaptive immune responses to improve tumor therapy. Recently, novel drugs of TLR7 or TLR8 agonists with different scaffolds have been developed. These agonists lead to the induction of certain cytokines and chemokines that can be applied to the treatment of some diseases and can be used as good adjutants for vaccines. Furthermore, TLR7/8 agonists as potential therapeutics for tumor-targeted immunotherapy have been developed. In this review, we summarize the recent advances in the development of immunotherapy strategies targeting TLR7/8 in patients with various cancers and chronic hepatitis B.
Hong Kong’s new wave of migration: socio-political factors of individuals’ intention to emigrate
Authors: Chan Anita Kit Wa , Cheung Lewis T. O. , Chong Eric King-man , Lee Man Yee Karen , Wong Mathew Y. H. 
Published: December 2022

AbstractWith a recent surge in the outward movement of the population, a new wave of emigration has been suggested to have started in Hong Kong. It is speculated that recent socio-political changes in Hong Kong may have contributed to this phenomenon. Therefore, five socio-political variables—mobility, sense of place, trust and confidence in the law and the legal system, global citizenship, and perception of inequality—are employed in this study as proposed determinants to investigate the intention of Hong Kong residents to migrate to mainland China and to other international destinations. A random telephone questionnaire survey representative of the local population was conducted, with a total of 801 valid samples collected. Stepwise multiple regression analysis was carried out. The results showed that all five proposed socio-political variables successfully predicted people’s migration intention to mainland China and to foreign countries, with important variations between the two choices. Our results carry strong implications for understanding people’s concerns behind their intention to emigrate. Further, our findings present a challenge for Hong Kong; society may gradually be failing to accommodate individuals with diverse perceptions and values, particularly in terms of trust and confidence in the law and the legal system, and individuals’ sense of global citizenship.
Research hotspots and trends for axon regeneration (2000–2021): a bibliometric study and systematic review
Authors: Chou Yuyu , Nawabi Homaira , Li Jingze 
Published: December 2022

Abstract
Background
Axons play an essential role in the connection of the nervous system with the rest of the body. Axon lesions often lead to permanent impairment of motor and cognitive functions and the interaction with the outside world. Studies focusing on axon regeneration have become a research field with considerable interest. The purpose of this study is to obtain an overall perspective of the research field of axonal regeneration and to assist the researchers and the funding agencies to better know the areas of greatest research opportunities.

Methods
We conducted a bibliometric analysis and Latent Dirichlet Allocation (LDA) analysis of the global literature on axon regeneration based on the Web of Science (WoS) over the recent 22 years, to address the research hotspots, publication trends, and understudied areas.

Results
A total of 21,018 articles were included, which in the recent two decades has increased by 125%. Among the top 12 hotspots, the annual productions rapidly increased in some topics, including axonal regeneration signaling pathway, axon guidance cues, neural circuits and functional recovery, nerve conduits, and cells transplant. Comparatively, the number of studies on axon regeneration inhibitors decreased. As for the topics focusing on nerve graft and transplantation, the annual number of papers tended to be relatively stable. Nevertheless, the underlying mechanisms of axon regrowth have not been completely uncovered. A lack of notable research on the epigenetic programs and noncoding RNAs regulation was observed. The significance of cell-type-specific data has been highlighted but with limited research working on that. Functional recovery from neuropathies also needs further studies.

Conclusion
The last two decades witnessed tremendous progress in the field of axon regeneration. There are still a lot of challenges to be tackled in translating these technologies into clinical practice.
What Is Philology? From Crises of Reading to Comparative Reflections
Authors: Helle Sophus 
Published: December 2022

AbstractThe article proposes a new definition of philology as a systematic engagement with crises of reading, focused on the difficulties that prevent readers from gaining access to or drawing meaning from a given text, all the way from scrubbed signs to obscure ontologies. Responding to two recent interventions in the field—Philology by James Turner and World Philology by Sheldon Pollock, Benjamin A. Elman, and Ku-ming Kevin Chang—the article explores the practices, history, and current state of philology. It argues that a resurgence of philological self-reflection over the past twelve years is bringing the field into view as a global, transhistorical, and anti-disciplinary practice, spanning many centuries and continents, and encompassing a wealth of methodological tools and approaches. These new developments promise to revitalize a field that currently finds itself in disciplinary disarray, by infusing it with a global and self-critical awareness. But the vision presented by Turner and the editors of World Philology, of philology as an inherently cross-disciplinary, cross-cultural practice, necessitates a clearer delimitation of what philology is, which the present article sets out to provide.
“To Tell a Story by Not Telling It”: Toward a Networked Poetics of Delay in Anne Carson'sThe Beauty of the Husband
Authors: Van Praet Helena 
Published: December 2022

AbstractThis article addresses the literary response to network forms in twenty-first-century print poetry. Through the case of Anne Carson's long poem The Beauty of the Husband (2001), it explores how contemporary poetry, whose textuality will be termed prosthetic, can engender a network aesthetic that evokes infinite connections among ideas that are analogically related. Firstly, taking its cue from recent developments in literary history and relational aesthetics, the article investigates how Carson's poem participates in a network aesthetic typical of the digital age. To this end, it situates this aesthetic in the context of an emergent metamodernism by relating the notion of connection, central to network aesthetics, to an ethos of affect and sincerity characteristic of metamodernism. The literary analysis, which focuses on five key hubs, then demonstrates how the poem never arrives at representation and yet evokes a disintegrating marriage by analogically relating it to other ideas and texts. The article concludes that Carson's poem operates by means of a poetics of delay by reconciling lyrical with conceptual impulses. Ultimately, the aim of this article is to flesh out a fuller picture of Carson's notoriously uncategorizable poetry against the background of a network aesthetic.
Playful Poetics: Metareferential Interfaces in Recent Indie Games
Authors: Krampe Theresa , Lotzow Stephanie , Thon Jan-Noël 
Published: December 2022

AbstractThis article sets out to explore the playful poetics of recent indie games in terms of what could be described as metareferential interfaces. Drawing on a range of theories from literary studies, media studies, and game studies, we propose to conceptualize metareferential interfaces as interfaces that foreground and draw attention to their own mediality. They thus allow for videogame-specific forms of metareference and metalepsis to be employed as part of often quite experimental and aesthetically ambitious approaches to videogame design. Using the recent indie games Pony Island (2016) and OneShot (2016) as our core case studies, we offer an in-depth analysis of this metaization of videogames’ playful poetics, focusing primarily on three salient aspects: First, the multiplication of interfaces can lead to mise-en-abyme-like structures that highlight and reflect on the mediality of videogames while also establishing ontological boundaries between different levels of videogame storyworlds. Second, the disruption of interface functionality is a metareferential strategy that can be used to establish specific gameplay challenges and reflect on the design conventions of videogame interfaces. Third, the transgression of ontological boundaries affects not only the borders between subworlds within a videogame's storyworld but also the more fundamental distinction between what is “in the game” and what is “outside it.”
Brokerage House Initial Public Offerings and Analyst Forecast Quality
Authors: Bradshaw Mark , Drake Michael , Pacelli Joseph , Twedt Brady 
Published: December 2022

We examine how brokerage firm initial public offerings (IPOs) influence the research quality of sell-side analysts employed by the brokerage. Our main results focus on earnings forecast bias and absolute forecast errors as proxies for research quality. Using a staggered difference-in-differences analysis, we document significant decreases in forecast bias and absolute forecast error during the two-year period centered on the analysts’ brokerage house IPO. In additional analyses, we explore several potential explanations for the short-term benefits of brokerage house IPOs. We find some evidence that IPOs delay the departure of more talented analysts and that the effects are more concentrated among analysts and brokers that face more scrutiny. This paper was accepted by Brian Bushee, accounting. Supplemental Material: Data are available at https://doi.org/10.1287/mnsc.2022.4610 .
DEMETRA: um periódico em constante aprimoramento
Authors: Feldenheimer da Silva Ana Carolina , Brum Martucci Renata 
Published: December 2022

A Revista Demetra: Alimentação, Nutrição & Saúde, antes Revista Ceres: Nutrição e Saúde, vem mantendo suas atividades desde o ano de 2006. Durante esses mais de 15 anos, a revista passou por mudanças e aprimoramentos, aumentando sua importância e relevância na missão de ampliar a comunicação de trabalhos científicos desenvolvidos no campo da Alimentação, Nutrição e Saúde.De 2018 a 2021, a revista foi coordenada pelas Professoras Josely Koury e Luciana Castro, sucedendo as Professoras Fabiana Kraemer e Shirley Prado, todas do Instituto de Nutrição da Universidade do Estado do Rio Janeiro, às quais agradecemos por toda dedicação e empenho na manutenção da publicação e pelo constante avanço na qualidade do periódico. Neste momento de renovação, também gostaríamos de agradecer à equipe editorial e aos editores associados e pareceristas, que têm o importante papel de fazer a revista acontecer. Nosso “muito obrigada” a todos.Nos últimos anos, a revista passou por uma série de melhorias, como a indexação na plataforma LILACS, além da indexação em outras bases (J4F - Journals for Free; FMJ - Free Medical Journals; LATINDEX - Sistema Regional de Información en Línea para Revistas Científicas de América Latina, el Caribe, España y Portugal; DOAJ - Directory of Open Access Journals; ROAD - Directory of Open Access Scholarly Resource; DRJI - Directory of Research Journals Index; OAJI - Open Academic Journals Index; DIADORIM - Diretório de Políticas de Acesso Aberto das Revistas Científicas Brasileiras; PERIÓDICA - Índice de Revistas Latinoamericanas en Ciencias; GALE - Cengage-Learning; PERIÓDICOS CAPES; GOOGLE SCHOLAR; REDIB - Red Iberoamericana de Innovación y Conocimiento Científico), instituição de um Conselho Editorial Deliberativo, ampliação do corpo de editores assistentes, com representação das diversas regiões do país, readequação do layout da página da revista, instituição do fluxo contínuo para publicação de artigos, criação de perfil nas redes sociais e a manutenção de todas as atividades durante o período de isolamento social. Atualmente, a Revista Demetra é classificada como B4 na área da Nutrição (classificação QUALIS da Capes - 2016).No próximo período, teremos novos desafios na condução da revista, como a indexação na plataforma SciELO e a manutenção dos patamares de qualidade alcançados. Reconhecemos que muito foi feito e que ainda há uma série de conquistas e desafios que se colocam na editoria de uma revista cada vez mais conceituada na área de Alimentação, Nutrição e Saúde. Para este ano, será publicado um suplemento temático sobre “Dietética e promoção da alimentação adequada e saudável”, sobre o qual divulgaremos mais notícias em breve. Esperamos poder oferecer, em um futuro próximo, a oportunidade de novos suplementos em outras áreas temáticas de interesse dos leitores.Agradecemos o convite para ocupar a editoria da Revista Demetra e esperamos entregar para a comunidade acadêmica um trabalho à altura das expectativas. Sigamos juntos!
A GOVERNANÇA GLOBAL COMO INSTRUMENTO DE REGULAÇÃO JURÍDICA
Authors: Tiveron Julia Martins , Villas Bôas Filho Orlando 
Published: December 2022

O presente trabalho procura enfocar o conjunto de fenômenos que vem sendo abarcado pela terminologia “governança”. Esta aparece como uma ferramenta que visa dar conta do contexto complexo derivado das mudanças socioeconômicas associadas à globalização, as quais impõem a exigência por uma constante atualização das instituições políticas e jurídicas a fim de responderem aos problemas que se colocam no campo social. Destaca-se a abordagem realizada por André-Jean Arnaud, para quem a governança introduz uma nova lógica de tomada de decisão, que não equivale ao modelo top down, característico do direito tradicional. Trata-se de um instrumento de difícil definição, devendo ser compreendido por seu caráter difuso e plural. Ganha destaque a relação que se desenvolve entre direito e governança. Tal como apresentada por Jacques Chevallier, essa deve ser compreendida a partir de um processo de mútua influência e não como simples anulação. 10.12957/rfd.2020.43749
DESCONSIDERAÇÃO DA PERSONALIDADE JURÍDICA EM SOCIEDADES LIMITADAS APÓS A LEI DA LIBERDADE ECONÔMICA
Authors: Soares Dallemole Deborah , Tassinari Cardoso Fleischmann Simone 
Published: December 2022

A intenção deste artigo é analisar os possíveis impactos da Lei nº. 13.874/2019, a chamada Lei da Liberdade Econômica, na desconsideração da personalidade jurídica. Para isso, se abordará a personalidade jurídica e as teorias do patrimônio, bem como sua inserção no ordenamento brasileiro, a fim de que se possam identificar as bases históricas e dogmáticas que influenciaram o legislador pátrio. Depois, será estudada a sociedade limitada, por ser o modelo societário de maior difusão em nosso país, representando importante instrumento para a atividade comercial pela limitação da responsabilidade dos sócios pelas obrigações da sociedade ao seu investimento no capital social. Contudo, a separação patrimonial não é absoluta, de modo que a desconsideração da personalidade jurídica surge enquanto instrumento para atingir a esfera patrimonial individual do sócio em caso de abuso de direito em relação à personalidade jurídica. Na tentativa de dar garantias ao livre exercício de atividade econômica e limitar a intervenção estatal, foi promulgada a Lei nº. 13.874/2019, que trouxe maiores obstáculos à desconsideração, que somente deverá atingir os sócios que se beneficiarem direta ou indiretamente da fraude praticada, devendo esta ser devidamente comprovada por quem a alega. 10.12957/rfd.2020.49565
O DIREITO ADMINISTRATIVO SANCIONADOR NO MERCADO FINANCEIRO E DE CAPITAIS: AS MUDANÇAS PROMOVIDAS PELA LEI N° 13.506/2017 NO ÂMBITO DO BANCO CENTRAL DO BRASIL E DA COMISSÃO DE VALORES MOBILIÁRIOS
Authors: De Araujo Valter Shuenquener , Da Silva Harife Huri Eugenio , Palhares Rayssa Araújo de 
Published: December 2022

Este artigo se propõe a analisar o regime sancionador existente no âmbito do mercado financeiro e de capitais, tendo como foco as alterações promovidas pela Lei n° 13.506/2017. A pesquisa considerou a metodologia qualitativa, tendo um objetivo descritivo e explicativo e, ainda, uma análise crítica das regras jurídicas existentes sobre a temática. Quanto ao procedimento, a metodologia é bibliográfica e se ocupa da problemática acerca dos limites de atuação do BACEN e da CVM em matéria sancionatória. O texto também apresenta reflexões sobre a necessidade de se estabelecer um regime sancionador racional e proporcional no mercado financeiro e de capitais, bem como a Lei nº 13.655, que alterou a Lei de Introdução às Normas do Direito Brasileiro (LINDB), pode contribuir para se alcançar este objetivo. /rfd.2020.58343
MOTIVAÇÃO NOS LANÇAMENTOS DE OFÍCIO DO ICMS/RJ CONTEMPLANDO PERÍODOS COBERTOS PELA DECADÊNCIA
Authors: Pereira João Luís De Souza 
Published: December 2022

Apesar de já estar consolidada a jurisprudência do Superior Tribunal de Justiçaacerca da contagem do prazo decadencial em matéria tributária, a decadência ainda é temaque merece ser revisitado. Os lançamentos de ofício, exigindo ICMS, realizados pelaSecretaria de Fazenda do Estado do Rio de Janeiro não justificam o porquê de não serobservado o art. 150, §4º, do Código Tributário Nacional, quando se referem a fatosgeradores ocorridos há mais de cinco anos da ciência do auto de infração.Consequentemente, a discussão acerca do afastamento do art. 173, I, do CTN, inicia comclaro prejuízo ao direito de defesa do contribuinte. Daí, o porquê de se investigar anecessidade de o lançamento de ofício conter todas as informações úteis para o plenoexercício do direito de defesa pelo contribuinte no âmbito de um processo administrativojusto. 10.12957/rfd.2021.61605
Antipsychotics and emotionally unstable personality disorder: a literature review
Authors: Loader Katie 
Published: December 2022

Introduction This reviews aim was to explore the evidence base for the use of antipsychotic medications in the management of acute symptoms in patients with emotionally unstable personality disorder. Methods Relevant databases and grey literature were searched for relevant papers. Inclusion/exclusion criteria were applied which resulted in the retrieval of eight papers pertinent to the literature review. The papers were critically appraised, and a thematic analysis was undertaken to collate relevant data. Findings Five themes emerged from this literature review: different outcome measures, symptom domains (anger, impulsivity, mood instability, pseudopsychotic symptoms, self-harm and suicidal behaviours, adverse effects, the quality of the evidence and bias). Conclusions The evidence base is not robust enough to allow conclusions to be drawn. Any positive results must be weighed up against the potential for adverse events. This review lays the foundations for further research, which is needed to explore antipsychotic treatment.