bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medication Adherence Among Adults With Comorbid Chronic Conditions Initiating Oral Anticancer Agent Therapy for Multiple Myeloma
Authors: Gatwood Justin , Dashputre Ankur , Rajpurohit Abhijeet , Gatwood Katie , Mackler Emily , Wallace Leah , Farris Karen , Rizvi-Toner Amna , Farley Joel 
Published: June 2022

PURPOSE: Increased use of oral anticancer agents (OAAs) has empowered adults with multiple myeloma (MM) to manage their oncolytic therapy, but such a shift may result in issues with medication use, particularly among patients being concurrently treated for pre-existing, multiple chronic conditions. METHODS: This retrospective cohort study used 2013-2018 commercial and Medicare claims data to assess medication use in adults with MM. To be included, adults (18 years and older) must have been diagnosed with and had 2+ claims for an OAA, had continuous enrollment for 12 months before and after OAA initiation, and have been previously diagnosed with and had prescription fills for 2+ select chronic conditions. The proportion of days covered metric assessed medication adherence and was compared for 12 months before and after the OAA initiation by Wilcoxon signed-rank tests, McNemar's tests, and difference-in-differences models. RESULTS: The mean OAA adherence in the first year of therapy was 58.3% (standard deviation: 24.5) and 65.1% (standard deviation: 27.01) for commercial and Medicare patients, respectively. Adherence and the proportion adherent (proportion of days covered ≥ 80%) to comorbid therapies generally declined in the first year after OAA initiation. Changes in medication use were particularly noticeable among those on antihypertensive therapy: adjusted analyses uncovered a 2.5% (Medicare) and 5.2% (commercial) difference in adherence to these medications between those initially adherent and nonadherent to OAA therapy (both P < .05). CONCLUSION: Initiating OAA therapy in adults with MM may complicate an already complex treatment regimen, resulting in poor overall medication adherence in patients with multiple comorbid conditions.
CZO films: Effect of different post-annealing temperatures on electron-phonon interactions, steepness parameters, coordination numbers, optical mathematical equations, and skin depth
Authors: Dalouji Vali , Rahimi Nasim 
Published: June 2022

Abstract
The CZO films annealed at 500°C are smoother and they have the maximum value of electron-phonon interaction. The CZO films annealed at 500°C have the maximum value of optical density. The absorption edge of films up to 500°C has a redshift and over 500°C they have a blue shift. The CZO films annealed at 500°C have the minimum value of band-to-band transitions energy. The as-deposited CZO films are more disordered. The empirical optical mathematical equation from linear fitting for these films was given as

. It was demonstrated that values of the steepness parameters of CZO films are represented by a decreasing function while electron-phonon interactions by an increasing function with increasing annealing temperature. This may be ascribed to a change in iconicity and action valences of CZO films. Considering

,

, and

for ZnO, the coordination number constants

were calculated and for CZO films annealed at 600°C, β has a minimum value about of 0.18. Swanepoel method parameters also were obtained.
Hip Contact Force Magnitude and Regional Loading Patterns Are Altered in Those with Femoroacetabular Impingement Syndrome
Authors: SAVAGE TREVOR N. , SAXBY DAVID J. , LLOYD DAVID G. , HOANG HOA X. , SUWARGANDA EDIN K. , BESIER THOR F. , DIAMOND LAURA E. , EYLES JILLIAN , FARY CAMDON , HALL MICHELLE , MOLNAR ROBERT , MURPHY NICHOLAS J. , O’DONNELL JOHN , SPIERS LIBBY , TRAN PHONG , WRIGLEY TIM V. , BENNELL KIM L. , HUNTER DAVID J. , PIZZOLATO CLAUDIO 
Published: June 2022

ABSTRACT

Purpose
The magnitude and location of hip contact force influence the local mechanical environment of the articular tissue, driving remodeling. We used a neuromusculoskeletal model to investigate hip contact force magnitudes and their regional loading patterns on the articular surfaces in those with femoroacetabular impingement (FAI) syndrome and controls during walking.

Methods
An EMG-assisted neuromusculoskeletal model was used to estimate hip contact forces in eligible participants with FAI syndrome (n = 41) and controls (n = 24), walking at self-selected speed. Hip contact forces were used to determine the average and spread of regional loading for femoral and acetabular articular surfaces. Hip contact force magnitude and region of loading were compared between groups using statistical parametric mapping and independent t-tests, respectively (P < 0.05).

Results
All of the following findings are reported compared with controls. Those with FAI syndrome walked with lower-magnitude hip contact forces (mean difference, −0.7 N·BW−1; P < 0.001) during first and second halves of stance, and with lower anteroposterior, vertical, and mediolateral contact force vector components. Participants with FAI syndrome also had less between-participant variation in average regional loading, which was located more anteriorly (3.8°, P = 0.035) and laterally (2.2°, P = 0.01) on the acetabulum but more posteriorly (−4.8°, P = 0.01) on the femoral head. Participants with FAI syndrome had a smaller spread of regional loading across both the acetabulum (−1.9 mm, P = 0.049) and femoral head (1 mm, P < 0.001) during stance.

Conclusions
Compared with controls, participants with FAI syndrome walked with lower-magnitude hip contact forces that were constrained to smaller regions on the acetabulum and femoral head. Differences in regional loading patterns might contribute to the mechanobiological processes driving cartilage maladaptation in those with FAI syndrome.
Identifying the association of women’s empowerment with reproductive and maternal health practices using a cross-sectional study in the context of self-help groups in rural India
Authors: Irani Laili , Verma Supriya , Mohanan P. S. , Hazra Avishek 
Published: June 2022

Background: Globally, women’s empowerment is captured through different combinations of indicators related to their collective and individual empowerment. In this paper, the association of diverse domains related to women’s collective and individual empowerment on their reproductive and maternal health practices were assessed. Collective empowerment referred to a cluster of indicators measuring mutual support, rights, and access to services women received, as a result of membership in self-help groups (SHGs) focused on micro-finance activities. Women’s individual empowerment was measured through their perception to make decisions on their own, be mobile, financially self-reliant, self-confident in expressing themselves, having self-esteem and being free from spousal violence. Methods: Cross-sectional data were collected in 2017 from 2,197 SHG members across 57 administrative blocks of Uttar Pradesh, India. Using exploratory and confirmatory factor analysis, the sub-domains of individual and collective empowerment were developed. The reproductive and maternal health indicators included antenatal care, delivery preparedness, postnatal care and current contraceptive use. Bivariate and multivariate analyses, using logistic regression, were carried out to measure the association of sub-domains of women’s empowerment with health practices. Results: Collective and individual empowerment were independently and jointly associated with correct health practices. Women with greater empowerment through independent mobility, high self-esteem, access to financial resources, and confidence in interacting with a frontline worker, were more likely to access antenatal care. Similarly, delivery preparedness—which entailed deciding on the place of delivery, arranging for transportation during labor, and managing expenses for the delivery—was positively influenced by collective support from fellow SHG members. Receiving postnatal care was positively associated with self-confidence and financial autonomy, and current family planning method use was positively associated with self-confidence, lower spousal violence and confidence in support from the group. Conclusions: Women’s collective and individual empowerment were independently and jointly positively associated with health outcomes among SHG members.
Special meal of the Acehnese, Indonesia during Ramadhan
Authors: MANAN ABDUL , SALASIYAH CUT INTAN , RAHMAWATI SRI , SAPRIJAL SAPRIJAL , KHAIRISMAN KHAIRISMAN , CHAIRUNNISAK CHAIRUNNISAK 
Published: June 2022

Abstract. Manan A, Salasiyah CI, Rahmawati S, Saprijal, Khairisman, Chairunnisak. 2022. Special meal of the Acehnese, Indonesia during Ramadhan. Biodiversitas 23: 1187-1195. Ie Bu Peudah is a special meal of Acehnese, Indonesia society in every month of Ramadhan consisting of 44 kinds of mixed substances. All mixed ingredients are pounded or mashed using a special mortal done together and collectively. This study aimed to explore more deeply the origin of the making Ie Bu Peudah, its usefulness, social functions, and knowledge transfer amongst community. This descriptive analysis study employed observation, interview, questionnaire, and documentation to collect the data. The obtained data were analyzed by reducing, displaying, and concluding stages. The findings showed that the history of Ie Bu Peudah was carried by Indian traders that visited Aceh then the meal was recreated and modified by the local people in the sultanate of Aceh during 15 AD and was passed down over generations until today. Its efficacy was for body immunity, including the danger of coronavirus and healing many diseases like a tumor as it contains antioxidants, antibiotics, antiseptic, etc. Besides protecting from many diseases, Ie Bu Peudah also has the social functions which were to strengthen the friendship (silaturrahmi) among traditional figures and local people, strengthening the unity, glorifying the month full of blessing, preserving the harmony between the leaders of the village and people and upholding the values of togetherness during the month of Ramadhan.
Performance of tomato M7 mutant lines and their similarities to the parents based on SSR markers
Authors: ARRUFITASARI PUTRI NUR , SUTJAHJO SURJONO HADI , WIRNAS DESTA 
Published: June 2022

Abstract. Arrufitasari PN, Sutjahjo SH, Wirnas D. 2022. Performance of tomato M7 mutant lines and their similarities to the parents based on SSR markers. Biodiversitas 23: 1239-1245. Tomato cultivation in the lowlands can be an alternative to increase tomato production so that high-yielding and lowland adaptive varieties are required. This study was aiming at determining the performance of M7 mutant lines and their similarities to the parents based on SSR markers. The experiments were conducted at KP Leuwikopo (250 m asl) and Plant Molecular Biology Laboratory, IPB University, Indonesia. The results showed that the G4 line had the highest productivity among the tested genotypes (36.72 ton ha-1) and significantly differed from all check varieties. The highest number of fruit per plant was 51.67 in the G7 line. On the other hand, G2, G3, G7, G8, and G10 lines had the lowest percentage weight and the number of fruits cracking and were not significantly different from the check varieties (Tora and Mawar). A total of 7 SSR primers detected 87 alleles with a range of 7-15 alleles per locus. The similarity between mutant lines and their parents ranged from 44-69%. The mutant most closely resembled the parent was the G3 line, while the most different based on molecular markers was the G9 line.
Species diversity of subterranean ants in Rangsit Marsh, Khlong Luang District, Pathum Thani Province, Thailand
Authors: WANNA CHANATE WANNA , BOONMAN NARUMON , PHAKPAKNAM SIRIRAT , PIKULTHONG VACHIRAPORN , JAITRONG WEEYAWUT , SOI-AMPORNKUL RUNGTIP 
Published: June 2022

Abstract. Wanna C, Boonman N, Phakpaknam S, Pikulthong V, Jaitrong W, Soi-Ampornkul R. 2022. Species diversity of subterranean ants in Rangsit Marsh, Khlong Luang District, Pathum Thani Province, Thailand. Biodiversitas 23: 1283-1292. The present study aimed to compare species diversity and abundance of subterranean ants in three habitats: scrub forest, forest plantations, and glades at Rangsit Marsh, Khong Luang District, Pathum Thani Province, Thailand. The ant samples were collected twice a month during the rainy season (June-August 2019) and dry season (September-November 2019) using a pitfall trap in the soil. A total number of 6,305 individuals belonging to 4 subfamilies, 16 genera, and 16 species of ants were recorded. The subfamilies Myrmicinae comprising 6 species were the most prevalent, followed by 4 species of Formicinae, 3 species of Dolichoderinae, and 3 species of Ponerinae. The Shannon-Wiener species diversity index indicated the diversity was the highest in the glade (1.951), followed by the forest plantation (1.635), and lastly the scrub forest (0.419). Sorensen’s similarity coefficient to determine the similarity in community composition was highest between the forest plantation and the glade at 63.40%, and then between the scrub forest and the forest plantation at 44.30%, and between the scrub forest and the glade at 39.60%. This indicated that both ant species diversity and community composition were distinctly varied in these three sites. The rainy season revealed higher species richness than the dry season. The highest occurrence of ant species was for Iridomyrmex anceps (Roger, 1863), which was recorded as uncommon and was the most abundant species in the glade, while Anoplolepis gracilipes (Smith, 1857) and Carebara diversa (Jerdon, 1851) were the most abundant species in the scrub forest and forest plantation, respectively. Therefore, this study revealed that different habitat types and seasons resulted in differences in subterranean ant species diversity.
Whole-genome analysis of Bacillus subtilis G8 isolated from natto
Authors: DIKSON DIKSON , VICTOR HANS , JONG DELVIN , SANJAYA ASTIA , SAMANTHA ARIELA , JO JUANDY , PINONTOAN REINHARD 
Published: June 2022

Abstract. Dikson, Victor H, Jong D, Sanjaya A, Samantha A, Jo J, Pinontoan R. 2022. Whole-genome analysis of Bacillus subtilis G8 isolated from natto. Biodiversitas 23: 1293-1300. Bacillus subtilis-fermented soy-based food is associated with multiple health benefits. Various bacterial strains have been isolated from it, includingB. subtilisG8, recent isolation from Japanese natto commercially available in Indonesia. Both 16S rRNA gene sequencing and fibrinolytic activity characterization have been performed and published in prior studies. After comparison to the genome of a natto-isolated reference strain (i.e., B. subtilisBEST195), the B. subtilis G8 genome showed a similar guanine-cytosine (GC) content, predicted number of coding sequences (CDS) and predicted number of tRNA genes, but had a shorter sequence length and fewer predicted rRNA genes. Further analysis using multiple genome alignment with Mauve, average nucleotide identity (ANI) matrix calculation, and phylogenetic inference indicated that B. subtilis G8 was more related to natto-derived B. subtilis than to cheonggukjang-derived B. subtilis and B. subtilis 168. Finally, sequence analyses of a gene encoding nattokinase as well as two genes regulating poly-gamma-glutamic acid (?-PGA) production in B. subtilis G8, B. subtilis BEST195 and B. subtilis 168 clearly indicated that B. subtilis G8 is able to produce nattokinase and ?-PGA, which both contribute to natto’s fermentation process. Therefore, it is proposed that B. subtilis G8 should be reclassified as B. subtilis subsp. natto G8 to reflect that it is a natto-derived B. subtilis strain.
Increasing the diversity of marigold (Tagetes sp.) by acute and chronic chemical induced mutation of EMS (Ethyl Methane Sulfonate)
Authors: LENAWATY DEWI YANNY , SUKMA DEWI , SYUKUR MUHAMAD , SUPRAPTA DEWA NGURAH , NURCHOLIS WARAS , AISYAH SYARIFAH IIS 
Published: June 2022

Abstract. Lenawaty DY, Sukma D, Syukur M, Suprapta DN, Nurcholis W, Aisyah SI. 2022. Increasing the diversity of marigold (Tagetes sp.) by acute and chronic chemical induced mutation of EMS (Ethyl Methane Sulfonate). Biodiversitas 23: 1399-1407. Increasing the diversity of marigold (Tagetes sp.) can be carried out through chemical induction mutations with Ethyl Methane Sulfonate (EMS).This study aims to obtain the LC50value, determine the sensitivity level of plants, and obtain plant diversity of Tagetes sp.with EMS both acutely and chronically. The genetic material used in this study was derived from T. erecta genotype MG04 and T. patula genotype MG21. The acute mutation technique was performed by soaking the seeds in EMS concentration for 4 hours under 10 different concentration levels (0%, 0.2%, 0.4%, 0.6%, 0.8%, 1.0%, 1.5%, 2.0%, and 3.0%). The chronic mutation technique was carried out by diluting the concentration of EMS LC501/10x, 1/100x, 1/1000x and immersion time of 6 hours, 24 hours and 48 hours. The study used a Completely Randomized Block Design. Observationswere made on the percentage of surviving plants, quantitative and qualitative characters. The data obtained were analyzed using Boxplot and ANOVA. The results showed that the LC50 value of T. erecta is 0.82% and LC50of T. patula is 1.87%, which means that the sensitivity level of T. erecta to EMS treatment is quite higher than T. patula. The acute application method shows a relatively low mutation rate and limited diversity of flower types. The chronic application method produced various flower shapes and whiter flower color in T. erectaand T. patula resulting in a redder flower color than the acute application method.
Self-calibrated Fourier transform spectrometer for laser-induced fluorescence spectroscopy with single-photon avalanche diode detection
Authors: Gaire Vinod , Parker Colin V. 
Published: June 2022

Fourier transform spectrometers are commonly used in scientific and industrial settings because of their ability to record complete spectra with high signal-to-noise ratios. Using a single-photon avalanche diode as the detector improves the sensitivity but adds complications in laser-induced fluorescence applications related to detector saturation and acquisition time exceeding the typical scan time. Here, we report a spectrometer for the detection of laser-induced fluorescence signal together with the excitation light, and use the second harmonic signal from the excitation light to correct the phase and calibrate the spectrum, removing the need for a separate calibration source. We achieve a resolution of

0.4

c

m

−
1

in the wavelength range of 1140.2 nm, and demonstrate detection of signals with powers as low as

377

f
W

, with a noise floor of

172

f
W

/

c

m

−

1

.
Machine learning-based risk factor analysis and prevalence prediction of intestinal parasitic infections using epidemiological survey data
Authors: Zafar Aziz , Attia Ziad , Tesfaye Mehret , Walelign Sosina , Wordofa Moges , Abera Dessie , Desta Kassu , Tsegaye Aster , Ay Ahmet , Taye Bineyam 
Published: June 2022

BackgroundPrevious epidemiological studies have examined the prevalence and risk factors for a variety of parasitic illnesses, including protozoan and soil-transmitted helminth (STH, e.g., hookworms and roundworms) infections. Despite advancements in machine learning for data analysis, the majority of these studies use traditional logistic regression to identify significant risk factors.MethodsIn this study, we used data from a survey of 54 risk factors for intestinal parasitosis in 954 Ethiopian school children. We investigated whether machine learning approaches can supplement traditional logistic regression in identifying intestinal parasite infection risk factors. We used feature selection methods such as InfoGain (IG), ReliefF (ReF), Joint Mutual Information (JMI), and Minimum Redundancy Maximum Relevance (MRMR). Additionally, we predicted children’s parasitic infection status using classifiers such as Logistic Regression (LR), Support Vector Machines (SVM), Random Forests (RF) and XGBoost (XGB), and compared their accuracy and area under the receiver operating characteristic curve (AUROC) scores. For optimal model training, we performed tenfold cross-validation and tuned the classifier hyperparameters. We balanced our dataset using the Synthetic Minority Oversampling (SMOTE) method. Additionally, we used association rule learning to establish a link between risk factors and parasitic infections.Key findingsOur study demonstrated that machine learning could be used in conjunction with logistic regression. Using machine learning, we developed models that accurately predicted four parasitic infections: any parasitic infection at 79.9% accuracy, helminth infection at 84.9%, any STH infection at 95.9%, and protozoan infection at 94.2%. The Random Forests (RF) and Support Vector Machines (SVM) classifiers achieved the highest accuracy when top 20 risk factors were considered using Joint Mutual Information (JMI) or all features were used. The best predictors of infection were socioeconomic, demographic, and hematological characteristics.ConclusionsWe demonstrated that feature selection and association rule learning are useful strategies for detecting risk factors for parasite infection. Additionally, we showed that advanced classifiers might be utilized to predict children’s parasitic infection status. When combined with standard logistic regression models, machine learning techniques can identify novel risk factors and predict infection risk.
Effectiveness and safety of non-vitamin K direct oral anticoagulants in atrial fibrillation patients with bioprosthetic valve
Authors: Moon Inki , Go Tae-Hwa , Kim Jang Young , Kang Dae Ryong , Sohn Suk Ho , Lee Hyun-Jung , Choi Jae-Woong , Park Jun-Bean , Hwang Ho-Young , Kim Hyung-Kwan , Kim Yong-Jin , Kim Kyung-Hwan , Lee Seung-Pyo 
Published: June 2022

Background
Non-vitamin K direct oral anticoagulant (DOAC) is effective for prevention of embolic events in nonvalvular atrial fibrillation (AF) patients. However, the effectiveness and safety of DOAC in AF patients who have bioprosthetic heart valve (BPHV) is largely unknown.

Methods
We retrospectively identified patients with AF and BPHV, using the diagnostic code and medical device and surgery information from the Korean National Health Insurance Service database, between 2013 and 2018. A 1:2 propensity score-matched cohort (n = 724 taking warfarin; n = 362 taking DOAC) was constructed and analyzed for the primary clinical outcome, a composite of ischemic stroke and systemic embolism. Important secondary outcomes included major bleeding, all-cause death, and the net clinical outcome, defined as a composite of all embolic events, major bleeding, and death.

Results
The mean age was 78.9±6.8 years old, and 45% (n = 489) were male. The mean CHA2DS2-VASc score was 4.7±1.4. DOAC was non-inferior to warfarin for preventing ischemic stroke and systemic embolism (hazard ratio [HR] 1.14, 95% confidence interval [CI] 0.56–2.34), major bleeding (HR 0.80, 95% CI 0.32–2.03) and all-cause death (HR 1.09, 95% CI 0.73–1.63). As for the net clinical outcome, DOAC was also similar to warfarin (HR 1.06, 95% CI 0.76–1.47). These outcomes were not different in various subgroups analyzed.

Conclusion
In this nationwide Korean AF population with a BPHV, DOAC was at least as effective and safe as warfarin for the prevention of systemic embolic events. These results suggest that DOAC may be an excellent alternative to warfarin in AF patients with BPHV.