bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shift work, clinically significant sleep disorders and mental health in a representative, cross-sectional sample of young working adults
Authors: Reynolds Amy C. , Lechat Bastien , Melaku Yohannes Adama , Sansom Kelly , Brown Brandon W. J. , Crowther Meagan E. , Wanstall Sian , Maddison Kathleen J. , Walsh Jennifer H. , Straker Leon , Adams Robert J. T. , McArdle Nigel , Eastwood Peter R. 
Published: September 2022

AbstractMental health conditions confer considerable global disease burden in young adults, who are also the highest demographic to work shifts, and of whom 20% meet criteria for a sleep disorder. We aimed to establish the relationship between the combined effect of shift work and sleep disorders, and mental health. The Raine Study is the only longitudinal, population-based birth cohort in the world with gold-standard, Level 1 measurement of sleep (polysomnography, PSG) collected in early adulthood. Participants (aged 22y) underwent in-laboratory PSG and completed detailed sleep questionnaires. Multivariable adjusted robust linear regression models were conducted to explore associations with anxiety (GAD7) and depression (PHQ9), adjusted for sex, health comorbidities, and work hours/week. Data were from 660 employed young adults (27.3% shift workers). At least one clinically significant sleep disorder was present in 18% of shift workers (day, evening and night shifts) and 21% of non-shift workers (p = 0.51); 80% were undiagnosed. Scores for anxiety and depression were not different between shift and non-shift workers (p = 0.29 and p = 0.82); but were higher in those with a sleep disorder than those without (Md(IQR) anxiety: 7.0(4.0–10.0) vs 4.0(1.0–6.0)), and depression: (9.0(5.0–13.0) vs 4.0(2.0–6.0)). Considering evening and night shift workers only (i.e. excluding day shift workers) revealed an interaction between shift work and sleep disorder status for anxiety (p = 0.021), but not depression (p = 0.96), with anxiety scores being highest in those shift workers with a sleep disorder (Md(IQR) 8.5(4.0–12.2). We have shown that clinical sleep disorders are common in young workers and are largely undiagnosed. Measures of mental health do not appear be different between shift and non-shift workers. These findings indicate that the identification and treatment of clinical sleep disorders should be prioritised for young workers as these sleep disorders, rather than shift work per se, are associated with poorer mental health. These negative mental health effects appear to be greatest in those who work evening and/or night shift and have a sleep disorder.
Biosynthesis of copper oxide nanoparticles mediated Annona muricata as cytotoxic and apoptosis inducer factor in breast cancer cell lines
Authors: Mahmood Rana I. , Kadhim Afraa Ali , Ibraheem Sumayah , Albukhaty Salim , Mohammed-Salih Harraa S. , Abbas Ruaa H. , Jabir Majid S. , Mohammed Mustafa K. A. , Nayef Uday M. , AlMalki Faizah A. , Sulaiman Ghassan M. , Al-Karagoly Hassan 
Published: September 2022

AbstractThis study investigated for the first time a simple bio-synthesis approach for the synthesis of copper oxide nanoparticles (CuO NPs) using Annona muricata L (A. muricata) plant extract to test their anti-cancer effects. The presence of CuONPs was confirmed by UV–visible spectroscopy, Scanning electron microscope (SEM), and Transmission electron microscope (TEM). The antiproliferative properties of the synthesized nanoparticles were evaluated against (AMJ-13), (MCF-7) breast cancer cell lines, and the human breast epithelial cell line (HBL-100) as healthy cells. This study indicates that CuONPs reduced cell proliferation for AMJ-13 and MCF-7. HBL-100 cells were not significantly inhibited for several concentration levels or test periods. The outcomes suggest that the prepared copper oxide nanoparticles acted against the growth of specific cell lines observed in breast cancer. It was observed that cancer cells had minor colony creation after 24 h sustained CuONPs exposure using (IC50) concentration for AMJ-13 was (17.04 µg mL−1). While for MCF-7 cells was (18.92 µg mL−1). It indicates the uptake of CuONPs by cancer cells, triggering apoptosis. Moreover, treatment with CuONPs enhanced Lactate dehydrogenase (LDH) production, probably caused by cell membrane damage, creating leaks comprising cellular substances like lactate dehydrogenase. Hence, research results suggested that the synthesized CuONPs precipitated anti-proliferative effects by triggering cell death through apoptosis.
Evaluation of outcome from endovascular therapy for Budd-Chiari syndrome: a systematic review and meta-analysis
Authors: Mukhiya Gauri , Zhou Xueliang , Han Xinwei , Jiao Dechao , Pokhrel Gaurab , Li Yahua , Pokhrel Sita 
Published: September 2022

AbstractThis study was performed to evaluate the outcome of endovascular intervention therapy for Budd-Chiari syndrome (BCS) and compare recanalization, transjugular intrahepatic portosystemic shunt (TIPS)/direct intrahepatic portosystemic shunt (DIPS), and combined procedure treatment. For the meta-analysis, 71 studies were identified by searching four databases. The individual studies’ samples were used to calculate a confidence interval (CI 95%), and data were pooled using a fixed-effect model and random effect model. The pooled measure and an equal-weighted average rate were calculated in all participant studies. Heterogeneity between the studies was assessed with I2, and T2 tests, and publication bias was estimated using Egger’s regression test. A total of 4,407 BCS patients had undergone an endovascular intervention procedure. The pooled results were 98.9% (95% CI 97.8‒98.9%) for a technical success operation, and 96.9% (95% CI 94.9‒98.9%) for a clinical success operation. The re-intervention rate after the initial intervention procedure was 18.9% (95% CI 14.7‒22.9%), and the survival rates at 1 and 5 years after the initial intervention procedure were 98.9% (95% CI 96.8‒98.9%) and 94.9% (95% CI 92.9‒96.9%), respectively. Patients receiving recanalization treatment (98%) had a better prognosis than those with a combined procedure (95.6%) and TIPS/DIPS treatment (94.5%). The systematic review and meta-analysis further solidify the role of endovascular intervention treatment in BCS as safe and effective. It maintains high technical and clinical success and long-term survival rates. The recanalization treatment had a better prognosis and outcome than the combined procedures and TIPS/DIPS treatment.
New insights in the probability distributions of wave-by-wave overtopping volumes at vertical breakwaters
Authors: Salauddin M. , O’Sullivan J. J. , Abolfathi S. , Peng Z. , Dong S. , Pearson J. M. 
Published: September 2022

AbstractAdvances in the development of prediction tools for wave overtopping allow now for overtopping volumes to be estimated with good accuracy, with the combined use of mean overtopping rates and maximum wave by wave overtopping volumes in a sequence of wave overtopping events. While previous literature has tended to focus on mean overtopping rates at coastal structures, limited studies have investigated the wave by wave overtopping volumes at coastal sea defences; in particular, a paucity of studies have focussed on the prediction of the shape parameter in the Weibull distribution (i.e., Weibullb) of overtopping volumes. This study provides new insights on the probability distribution of individual wave overtopping volumes at plain vertical seawalls by analysing the measured Weibullbvalues derived from a series of laboratory experiments on seawalls performed on a wide range of wave conditions and crest freeboards. The influence of wave conditions (wave steepness, significant wave height), structural parameters (crest freeboard, toe water depth), impulsiveness, probability of overtopping waves, and overtopping discharge on Weibullbparameter were examined, and then compared with the well-established empirical formulae. For the conditions covered within this study, it was found that the probability distribution of wave-by-wave overtopping volumes follow a 2-parameter Weibull distribution. No apparent differences in Weibullbvalues were reported with the variation of incident wave steepness and impulsiveness parameter. Results of this study revealed that Weibullbvalues at vertical walls, subjected to non-impulsive wave conditions, can be predicted reasonably well using relative freeboard and relative overtopping rates. A new unified formula is proposed for the estimation of Weibullbvalues at vertical walls under impulsive and non-impulsive wave attack.
Vaginal microbial shifts are unaffected by oral pre-exposure prophylaxis in South African women
Authors: Mazibuko-Motau Noluthando , Sobia Parveen , Xu Jiawu , Elsherbini Joseph Ahmed , San James E. , Lewis Lara , Mtshali Andile , Mzobe Gugulethu , Ntuli Lungelo , Abdool Karim Salim S. , Mansoor Leila E. , Abdool Karim Quarraisha , Kwon Douglas S. , Archary Derseree , Ngcapu Sinaye 
Published: September 2022

AbstractVaginal microbiota have been shown to be a modifier of protection offered by topical tenofovir in preventing HIV infection in women, an effect not observed with oral tenofovir-based pre-exposure prophylaxis (PrEP). It remains unclear whether PrEP can influence the vaginal microbiota composition. This study investigated the impact of daily oral tenofovir disoproxil fumarate in combination with emtricitabine for PrEP on the vaginal microbiota in South African women. At baseline, Lactobacillus iners or Gardnerella vaginalis dominant vaginal communities were observed in the majority of participants. In cross sectional analysis, vaginal microbiota were not affected by the initiation and use of PrEP. Longitudinal analysis revealed that Lactobacillus crispatus-dominant “cervicotypes 1 (CT1)” communities had high probability of remaining stable in PrEP group, but had a higher probability of transitioning to L. iners-dominant CT2 communities in non-PrEP group. L. iners-dominant communities were more likely to transition to communities associated with bacterial vaginosis (BV), irrespective of PrEP or antibiotic use. As expected, BV-linked CTs had a higher probability of transitioning to L. iners than L. crispatus dominant CTs and this shift was not associated with PrEP use.
A message passing framework with multiple data integration for miRNA-disease association prediction
Authors: Dong Thi Ngan , Schrader Johanna , Mücke Stefanie , Khosla Megha 
Published: September 2022

AbstractMicro RNA or miRNA is a highly conserved class of non-coding RNA that plays an important role in many diseases. Identifying miRNA-disease associations can pave the way for better clinical diagnosis and finding potential drug targets. We propose a biologically-motivated data-driven approach for the miRNA-disease association prediction, which overcomes the data scarcity problem by exploiting information from multiple data sources. The key idea is to enrich the existing miRNA/disease-protein-coding gene (PCG) associations via a message passing framework, followed by the use of disease ontology information for further feature filtering. The enriched and filtered PCG associations are then used to construct the inter-connected miRNA-PCG-disease network to train a structural deep network embedding (SDNE) model. Finally, the pre-trained embeddings and the biologically relevant features from the miRNA family and disease semantic similarity are concatenated to form the pair input representations to a Random Forest classifier whose task is to predict the miRNA-disease association probabilities. We present large-scale comparative experiments, ablation, and case studies to showcase our approach’s superiority. Besides, we make the model prediction results for 1618 miRNAs and 3679 diseases, along with all related information, publicly available at http://software.mpm.leibniz-ai-lab.de/to foster assessments and future adoption.
Prenatal and early postnatal exposure to a natural disaster and Attention-Deficit/Hyperactivity Disorder symptoms in Indian children
Authors: Hanć Tomasz , Gomula Aleksandra , Nowak-Szczepanska Natalia , Chakraborty Raja , Kozieł Sławomir 
Published: September 2022

AbstractThe aim of this study was to assess the relation between early exposure to stressful events and symptoms of the Attention-Deficit/Hyperactivity Disorder (ADHD) in children, based on the outcomes from a natural experiment. It was hypothesized that children pre- and postnatally exposed to cyclone Aila have increased ADHD symptoms compared to the control group, and the effect depends on the timing of the exposure. Indian children (8–11 years) prenatally (N = 336) and early postnatally (N = 216) exposed to cyclone Aila were compared to a non-exposed control peer group (N = 285). ADHD symptoms were assessed using the Conner’s Teacher Rating Scale Revised. The main effect of exposure to the cyclone on the total ADHD symptoms’ score, ADHD index, Hyperactivity and Oppositional symptoms was significant and independent to covariates: age and sex of children, gestational age and birth weight, maternal stress during the year before the study and the socioeconomic status of a family. The timing of exposure and sex of the children were found to be a significant moderator of the relation between early exposure to the natural disaster and ADHD symptoms. The prenatal, but also early postnatal exposure to stressful experiences such as a natural disaster, may disturb the development of cognitive functions and behavioural control, thus increasing the risk of ADHD in children.
Honey bees save energy in honey processing by dehydrating nectar before returning to the nest
Authors: Nicolson Susan W. , Human Hannelie , Pirk Christian W. W. 
Published: September 2022

AbstractHoney bees process nectar into honey by active evaporation on the tongue and passive evaporation involving nest ventilation and fanning behaviour, as well as enzymatic action. The elimination of excess water from nectar carries considerable energetic costs. The concentration of the nectar load is assumed to remain constant during transport. However, some of this water elimination may occur before foragers return to the nest and pass their nectar loads to receiver bees. In honey bees captured while foraging in Macadamia orchards, we show that the nectar in their crops has approximately twice the sugar concentration of the fresh nectar in flowers. This was true for four Macadamia cultivars, with up to 75% of the initial water content being removed. There is a further concentration increase in the crops of returning bees captured at the hive entrance. The only possible route of water elimination from the crop is via evaporation from the mouthparts. We calculate the savings in honey processing costs to be on average 35 times more than the reduction in flight costs due to reduced body mass. Pre-concentration of nectar in foraging honey bees may be widespread, and of crucial importance for honey storage.
Race/Ethnicity, Gender, and Socioeconomic Status Representation in U.S.-Based Randomized Controlled Trials of Tinnitus: A Systematic Review
Authors: Deshpande Shruti Balvalli , Deshpande Aniruddha K. 
Published: September 2022

Purpose:
The purpose of this study was to investigate if peer-reviewed randomized controlled trials (RCTs) for the management/treatment of tinnitus conducted in the United States include diverse participants in terms of gender, race/ethnicity, education, occupation, and income.

Method:
We performed a comprehensive and systematic literature search via PubMed, Web of Science, Clinical-Trials.gov, and the Cochrane Central Register of Controlled Trials. Our goal was to identify prospective RCTs of tinnitus intervention conducted in the United States from January 1994 to September 2021 and published in peer-reviewed journals.

Results:
A total of 2,584 studies were retrieved. Thirty-two peer-reviewed articles met all inclusion criteria. Of the included studies, approximately 96% reported participants' gender. Approximately 15% studies reported race/ethnicity information in alignment with the U.S. Census Bureau. However, an underrepresentation of both females and people of color was evident across studies. Reporting of socioeconomic status information of participants was also scarce, with only 25% studies reporting education and/or occupation of participants and 0% reporting income levels.

Conclusions:
This study indicates underrepresentation and underreporting of diverse participant pools in tinnitus research. Reasons for such underrepresentation are explored. Additionally, this systematic review indicates that recent research in tinnitus portrays an optimistic trend in terms of reporting and recruitment of diverse participant groups. Sustainable strategies for including diverse research participants are essential for hearing health care equity. Research and strategies to promote this goal are discussed.
Social-Pragmatic Skills and Length of Bilingualism Predict Inhibitory Control in Children
Authors: Slawny Caitlyn , Crespo Kimberly , Weismer Susan Ellis , Kaushanskaya Margarita 
Published: September 2022

Purpose:
There is conflicting evidence regarding effects of bilingualism on inhibition, and the mechanisms that might underlie the effects remain unclear. A prominent account views additional demands on structural language use in bilinguals as being at the root of bilingual effects on inhibition. In this study, we tested the novel hypothesis that social-pragmatic skills (alone or together with structural language skills) are associated with inhibition in bilingual children.

Method:
Parents of 114 typically developing 8- to 11-year-old Spanish–English bilingual children completed the Children's Communication Checklist–Second Edition to index social pragmatics and the Behavior Rating Inventory of Executive Function to index executive functioning skills. The Inhibit clinical scale score reflected children's inhibition. Children's language ability was indexed by the Clinical Evaluation of Language Fundamentals–Fourth Edition in English and Spanish. Length of bilingualism was operationalized continuously as the length of time children had been exposed to both languages in their lifetime. Moderation analyses tested the effects of structural language, social-pragmatic skills, and length of bilingual experience, and their interactions on inhibition.

Results:
While structural language skills were not associated with inhibition, they moderated the relation between social-pragmatic skills and inhibition, such that children with better social-pragmatic skills demonstrated better inhibition, and this effect was stronger for children with better structural language skills. Furthermore, longer length of bilingual experience was associated with better inhibition, and this effect was not moderated by any other predictor.

Conclusion:
These results confirm a graded relationship between bilingualism and inhibition, and indicate that this association is not qualified by structural language or social-pragmatic skills.

Supplemental Material:

https://doi.org/10.23641/asha.21183916
Energy forecasting in smart grid systems: recent advancements in probabilistic deep learning
Authors: Kaur Devinder , Islam Shama Naz , Mahmud Md Apel , Haque Md Enamul , Dong Zhao Yang 
Published: September 2022

AbstractEnergy forecasting plays a vital role in mitigating challenges in data rich smart grid (SG) systems involving various applications such as demand‐side management, load shedding, and optimum dispatch. Managing efficient forecasting while ensuring the least possible prediction error is one of the main challenges posed in the grid today, considering the uncertainty in SG data. This paper presents a comprehensive and application‐oriented review of state‐of‐the‐art forecasting methods for SG systems along with recent developments in probabilistic deep learning (PDL). Traditional point forecasting methods including statistical, machine learning (ML), and deep learning (DL) are extensively investigated in terms of their applicability to energy forecasting. In addition, the significance of hybrid and data pre‐processing techniques to support forecasting performance is also studied. A comparative case study using the Victorian electricity consumption in Australia and American electric power (AEP) datasets is conducted to analyze the performance of deterministic and probabilistic forecasting methods. The analysis demonstrates higher efficacy of DL methods with appropriate hyper‐parameter tuning when sample sizes are larger and involve nonlinear patterns. Furthermore, PDL methods are found to achieve at least 60% lower prediction errors in comparison to other benchmark DL methods. However, the execution time increases significantly for PDL methods due to large sample space and a tradeoff between computational performance and forecasting accuracy needs to be maintained.
Motion stereo at sea: Dense 3D reconstruction from image sequences monitoring conveyor systems on board fishing vessels
Authors: Fisher Mark , French Geoffrey , Gorpincenko Artjoms , Holah Helen , Clayton Lauren , Skirrow Rebecca , Mackiewicz Michal 
Published: September 2022

AbstractA system that reconstructs 3D models from a single camera monitoring fish transported on a conveyor system is investigated. Models are subsequently used for training a species classifier and for improving estimates of discarded biomass. It is demonstrated that a monocular camera, combined with a conveyor's linear motion produces a constrained form of multiview structure from motion, that allows the 3D scene to be reconstructed using a conventional stereo pipeline analogous to that of a binocular camera. Although motion stereo was proposed several decades ago, the present work is the first to compare the accuracy and precision of monocular and binocular stereo cameras monitoring conveyors and operationally deploy a system. The system exploits Convolutional Neural Networks (CNNs) for foreground segmentation and stereo matching. Results from a laboratory model show that when the camera is mounted 750 mm above the conveyor, a median accuracy of <5 mm can be achieved with an equivalent baseline of 62 mm. The precision is largely limited by error in determining the equivalent baseline (i.e. distance travelled by the conveyor belt). When ArUco markers are placed on the belt, the inter quartile range (IQR) of error in z (depth) near the optical centre was found to be ±4 mm.