bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Clean and Healthy Behavior Activities In the Covid-19 Pandemic in Miftahul Islamic Boarding School, South Jakarta, Indonesia
Authors: Mulyanti Mulyanti , Subur Rina Yuliana , Rahayu Sri 
Published: October 2022

<p><strong>Introduction:</strong> The COVID-19 pandemic has hit countries around the world, including Indonesia. One of the sectors affected by the COVID-19 pandemic is the education sector. Educational institution in Indonesia has designed a distance learning program to prevent COVID-19 but not all educational institutions can implement this, for example an Islamic boarding school. The Pandemic COVID-19 causes the weakness of teaching and learning activities in islamic boarding school. However, teaching and learning activities must continue to be carried out with study times, to follow government directives in preventing the wider spread of the pandemic COVID-19. One of the ways to prevent the spread of COVID-19 is to wash your hands with soap and running water, also maintaining clean and healthy behavior activities.</p><p><strong>Method: </strong>This study uses a qualitative method with a descriptive phenomenological approach. The sample was selected purposively, the research informants were student Islamic Boarding School Miftahul, South Jakarta and key informants consisted of boarding school leaders, teachers in the boarding school environment on November 2021.</p><p><strong>Result: </strong>The results showed that the informants had behaved in a clean and healthy life both as an effort to prevent the covid-19 virus.</p><p><strong>Conclusion:</strong> It is hoped that the board and management of Islamic boarding schools can coordinate with local health center health workers to conduct health education related to Clean and Healthy Behavior (PHBS).</p><p><em> </em></p><p><strong><em> </em></strong></p><p align="center"> </p>
Stratified support pattern-based internet-assisted self-management therapy for MCI associated with DM: a randomized controlled trial protocol
Authors: Wang Yun-xian , Lin Rong , Yan Yuan-jiao , Li Hong 
Published: October 2022

Abstract
Background: Mild cognitive impairment (MCI) associated with diabetes mellitus (DM) is common among elderly individuals, and self-management is critical to controlling disease progression. However, both MCI and DM are heterogeneous diseases, and existing integrated self-management interventions do not consider patient differences. Grouping patients by disease characteristics could help to individualize disease management and improve the use of available resources. The current study sought to explore the feasibility and effectiveness of a stratified support model.
Methods: A randomized controlled trial will be conducted after dividing MCI associated with DM patients into an intervention group and a control group in a 1:1 ratio. The intervention group will receive a self-management intervention using the “internet +” stratified support mode, while the control group will receive the health manual integrated intervention mode. After 12 weeks, cognitive function, blood glucose, self-management ability, and psychological status of patients in both groups will be measured and compared.
Discussion: This study developed an “internet +” stratified support mode to provide self-management intervention for patients with MCI associated with DM. The impact of different models and forms of self-management intervention on cognitive function, blood glucose management, and psychological status will be assessed. The results of this study should inform related cognitive intervention research on stratification and the internet, and help to slow the decline of cognitive function in patients with MCI associated with DM.
Trial registration: ChiCTR2200061991. Registered 16 July 2022.
Multi-omics Research on the Heterogeneity and Immune Landscape of Lung Adenocarcinoma with Ground-glass opacity
Authors: Miao Huiwen , Teng Xiao , Teng Xiaodong , Fu Shaozi , Gao Meihui , Xu Heyun 
Published: October 2022

Abstract
Background:
Lung adenocarcinoma with ground-glass opacity (GGO) has been detected increasingly and now accounts for most lung cancer patients. Lung adenocarcinoma with GGO contains a complex ecosystem. The mechanism of lung adenocarcinoma with GGO remains largely elusive. We use mass spectrometry proteomics combined with metabolomics to understand how these characteristics achieve a long-term functional balance and the trend of changes in tumor progression at the cellular functional level.
Methods:
We initiated a prospective cohort study to characterize lung adenocarcinoma with GGO components or without GGO components. Tumor and para-cancer tissue samples were collected. Multi-omics including transcriptomics proteomics and metabonomics were performed.
Results:
We found lung adenocarcinoma with GGO had a relatively slow proliferation tumor cells and stronger immune cell infiltration in proteomic and transcriptomic analysis. The immune cell markers expression, including CD47, CD68, CD81, CD86, C1Q, SPP1, CXCL13, ALOX5AP and HPGD was found overexpression in lung adenocarcinoma with GGO, which indicated more immune cell infiltration. In metabolomic analysis, GAPDH, ENO1 and LDHA were highly expressed in pure-solid lung adenocarcinoma, and GPD1 was highly expressed in lung adenocarcinoma with GGO. The combined transcriptome and proteome analysis revealed that proteins with consistent differences mainly included GAPDH, MKI67, AGER, and CRYM. KEGG pathway enrichment analysis showed that several aliphatic acyclic compounds expression were higher in lung adenocarcinoma with GGO.
Conclusion:
We describe a functional homeostasis in lung adenocarcinoma with GGO, which was constructed by relatively slow proliferation tumor cells and stronger immune cell infiltration. Overexpression of CXCL13 drives the infiltration of immune cells, which means the formation of anti-tumor tertiary lymphatic structures. The dysfunction of macrophage may be an important marker of this progression.
Gamma' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity
Authors: Kornblith Lucy Z. , Sadhanandhan Bindhya , Arun Sreepriya , Long Rebecca , Johnson Alicia J. , Noll Jamie , Ramchand C. N. , Olynyk John K. , Farrell David H. 
Published: October 2022

Abstract

Coronavirus disease 2019 (COVID-19) is characterized by a pro-inflammatory state associated with organ failure, thrombosis, and death. We investigated a novel inflammatory biomarker, γ' fibrinogen (GPF), in 103 hospitalized patients with COVID-19 and 19 healthy controls. We found significant associations between GPF levels and the severity of COVID-19 as judged by blood oxygen saturation (SpO2). The mean level of GPF in the patients with COVID-19 was significantly higher than in controls (69.8 (95% CI 64.8–74.8) mg/dL compared with 36.9 (95% CI 31.4–42.4) mg/dL, p < 0.0001), whereas C-reactive protein (CRP), lactate dehydrogenase (LDH), and total fibrinogen levels were not significantly different between groups. Mean GPF levels were significantly highest in patients with severe COVID-19 (SpO2 ≤ 93%, GPF 75.2 (95% CI 68.7–81.8) mg/dL), compared to mild/moderate COVID-19 (SpO2 > 93%, GPF 62.5 (95% CI 55.0–70.0) mg/dL, p = 0.01, AUC of 0.68, 95% CI 0.57–0.78; Youden's index cutpoint 62.9 mg/dL, sensitivity 0.64, specificity 0.63). In contrast, CRP, interleukin-6, ferritin, LDH, D-dimers, and total fibrinogen had weaker associations with COVID-19 disease severity (all ROC curves with lower AUCs). Thus, GPF may be a useful inflammatory marker of COVID-19 respiratory disease severity.
Ortho-palladated complexes with aromatic N-donor ligands, synthesis, characterization, molecular structures, antibacterial and anticancer activity
Authors: Afandi Zana S. , Al-Jibori Subhi A. , Ferjani Hela , Al-Shammar Riyadh H. , Aldossari Samar Abdullah , Al-Janabi Ahmed S. 
Published: October 2022

Abstract
Ten newly synthesized ortho-palladated complexes of the type [PdCl(bhq)L] (1–10) (where bhp = benzo[H]quinolate, L = 2-aminobenzothiazole (2-abt), 2-amino-benzimidazole(2-abi), 2-aminothiazole(at), imidazole(im), 2-aminopyridine(2-apy), 2-amino-3-methylpyridine(2-ampy), 2-amino-5-chloropyridine(2-acpy), 3-methyl-pyridine (3-mpy), 2-methylpyridine(2-mpy)or2-pyridinemethaneamine (2-pyma) have been prepared by bridge opening reaction of dimeric [PdCl(bhq)]2 with two equivalent of various aromatic N-donor ligands(L). The prepared complexes were characterized using IR, 1H n.m.r, mass spectroscopy, molar conductance and X-ray crystallography. The result refer to that all complexes have neutral square planar shape except complex (10) is ionic have electric conductance (40µs), then approved by addition of AgNO3 solution to afford white precipitate of AgCl. The biological activity of the prepared complexes were examined against Pseudomonas aeruginosa, Escherichia coli and staphylococcus aurous. The complexes showed good to moderate activity against the three pathogenic bacteria, Further more complex 4, displays a highest anti-bacterial activity than the other complexes. Some of synthesized complexes were evaluated as anticancer, screening against A2780 and HCT-116 cell lines using the MTT colorimetric assay. The [Pd(bhq)Cl(im)] (4) complex exhibited significant cytotoxicity against the HCT-116 and A2780 cell lines with IC50 values are 8.67 ± 1.04 µM and 6.32 ± 0.86 µM for respectively.
Stability and pattern formation in a general class of reaction-diffusion-advection system
Authors: Maimaiti Yimamu , Yang Wenbin 
Published: October 2022

Abstract
This paper focuses on a general class of reaction-diffusion-advection system with linear cross-diffusion and cross-advection. By investigating the linearized stability of the constant equilibrium solution, we prove that the self-diffusion and self-advection terms have no effect on the stabilization of the constant steady state, the linear cross terms favor the destabilization of the constant steady state and mechanism of pattern formation. The theoretical results are applied to predator-prey and water-vegetation models with cross-diffusion and cross-advection.
Arabic Text to Image Generation Tasks
Authors: BAHANI Mourad 
Published: October 2022

Abstract
Current AI systems have shown impressive results in the Automatic synthesis realistic images from texts descriptions tasks. In fact, Generative Adversarial Networks (GANs) are used mostly in this tasks. The Generator generates realistic images given noise and sentence vectors, and the discriminator produce a probability of how the synthetic images are reals. In this paper, in order to generate images from Arabic text, we fuse DF-GAN as a sample and efficient text-to-image generation framework and AraBERT architecture. To achieve this purpose, firstly, we re-create new datasets matching the Arabic text-to-image generation task by applying DeepL-Translator from English to Arabic on texts descriptions of original datasets. Secondly, we leverage the power of AraBERT which is trained on billions of Arabic words to produce a strong sentence embedding, and we reduce that vector's dimension to match with DF-GAN shape. Thirdly, we inject the reduced sentence embedding into the UPBlocks sections of DF-GAN and we train the proposed architecture on two challenging datasets. Following the previous works, we use CUB and Oxford-102 flowers as original datasets. Further, we measure our framework with FID and IS. Our framework is the first that achieve much success in generating high-resolution realistic and text matching images conditioned with Arabic text.
Involvement of Proteasome and Endoplasmic Reticulum Stress in Neurodegeneration after Global Brain Ischemia
Authors: Ziakova Katarina , Kovalska Maria , Pilchova Ivana , Dibdiakova Katarina , Pokusa Michal , Kalenska Dagmar , Racay Peter 
Published: October 2022

Abstract
A brief period of transient global brain ischemia leads to a selective ischemic neurodegeneration associated with death of hippocampal CA1 pyramidal neurons days after reperfusion. The mechanism of such selective and delayed neurodegeneration is still uncertain. The aim of our work was to study an involvement of proteasome and endoplasmic reticulum (ER) stress in ischemic neurodegeneration. We have performed laser scanning confocal microscopy analysis of brain slices from control and experimental animals that underwent global brain ischemia in duration of 15 minutes and varying times of reperfusion. We have focused on ubiquitin, PUMA that is proapoptotic protein of Bcl-2 family overexpressed in response to both proteasome and ER stress, and p53 that controls expression of PUMA. We have also examined expression of HRD1, E3 ubiquitin ligase that was shown to be overexpressed after ER stress. Using cellular models of both proteasome and ER stress, we have examined possible crosstalk between proteasome and ER stress. We demonstrate that global brain ischemia is associated with an appearance of distinct immunoreactivity of ubiquitin, PUMA and p53 in pyramidal neurons of CA1 layer of hippocampus 72 hours after ischemic insults. Such changes corelate with a delay and selectivity of ischemic neurodegeneration. Immunoreactivity of HRD1 observed in all investigated regions of rat brain was transiently absent in both CA1 and CA3 neurones 24 hours after ischemia in hippocampus that does not correlate with a delay and selectivity of ischemic neurodegeneration. We do not document significant crosstalk between proteasome and ER stress. Our results are in favour of dysfunction of ubiquitin proteasome system and consequent p53-induced expression of PUMA as the main mechanisms responsible for selective and delayed degeneration of pyramidal neurons of hippocampal CA1 layer in response to global brain ischemia.
Effects of the coronavirus disease 2019 pandemic on anxiety and spirituality in patients with cancer undergoing chemotherapy: a cross-sectional study
Authors: Oliveira Francisca Fernanda Barbosa , Carlos Anna Clara Aragão Matos , Crispim André Alves , Coelho Lívia Moreira Caetano , Malta Cássia Emanuella Nóbrega , de Souza Thuany Pinto Rocha , Silva-Fernandes Isabelle Joyce de Lima , Silva Paulo Goberlânio de Barros 
Published: October 2022

AbstractPurpose To evaluate anxiety and spirituality levels in oncology patients during the coronavirus disease 2019 (COVID-19) pandemic. Methods This short-term cross-sectional study applied a previously validated General Anxiety Disorder-7 (GAD7) scale and spirituality inventory to 230 patients undergoing antineoplastic chemotherapy during the second wave of COVID-19 in Brazil. The means ± SD of the scales were calculated and correlated (Spearman'srho). After categorization, chi-square and multinomial regression models were used to identify risk factors (p < 0.05). Results The levels of anxiety (6.16 ± 5.11) and spirituality (17.22 ± 2.66) were moderately and inversely correlated (p = 0.001, r = -0.212). Women (p = 0.025), fatigue (p = 0.048), and insomnia (p = 0.001) were associated with an increased incidence of anxiety; however, spirituality was associated with a reduced incidence of fatigue (p = 0.032). Death of family or friends due to COVID-19 increased the risk of high levels of anxiety (p < 0.05), while in multivariate analysis, insomnia (p = 0.030) and sleep difficulty (p = 0.031) were also directly associated with anxiety and spirituality reduced the interruption of chemotherapy during the COVID-19 pandemic (p = 0.036). Conclusion and Implications for Cancer Survivors: Fear of the COVID-19 pandemic altered the psychoemotional environment of patients undergoing chemotherapy, resulting in increased levels of anxiety. However, spirituality was an important coping strategy in patients undergoing cancer treatment.
Subclavian vein ultrasound-guided fluid management to prevent post-spinal anaesthetic hypotension: a randomized controlled trial
Authors: Lu Yan , Zhang Yueqi , Shen Fuyi , Xu Zhendong , Liu Zhiqiang 
Published: October 2022

AbstractBackground Hypotension frequently occurs after spinal anaesthesia during caesarean delivery, which is recommended to prevent by fluid loading. We evaluated subclavian vein (SCV) ultrasound (US)-guided volume optimisation in preventing hypotension after spinal anaesthesia during caesarean delivery. Methods This randomised controlled study included 80 consecutive full-term parturients scheduled for caesarean delivery under spinal anaesthesia. Women were randomly divided into the SCVUS group, comprising SCVUS analysis before spinal anaesthesia with SCVUS-guided volume management, and the control group without SCVUS assessment. Before anaesthesia, the SCVUS group received 3 mL/kg crystalloid fluid challenges repeatedly within 3 min with a 1-min interval based on the SCV collapsibility index (SCVCI), while the control group received a fixed dose (10 mL/kg). Incidence of post-spinal anaesthetic hypotension was the primary outcome. Total fluid volume, vasopressor dosage, changes in hemodynamic parameters, maternal adverse effects, and neonatal status were secondary outcomes. Results The total fluid volume was significantly higher in the control group than in the SCVUS group (690 [108] vs. 160 [280] mL, p < 0.001), while the phenylephrine dose (0 [40] vs. 0 [30] µg, p = 0.276) and incidence of post-spinal anaesthetic hypotension (65% vs. 60%, p = 0.950) were comparable. The incidence of maternal adverse effects, including nausea/vomiting and bradycardia (12.5% vs. 17.5%, p = 0.531 and 7.5% vs. 5%, p = 1, respectively), and neonatal outcomes (Apgar scores) were comparable between the groups. SCVCI correlated with the amount of fluid administered (R = 0.885, p < 0.001). Conclusions SCVUS-guided volume management did not ameliorate post-spinal anaesthetic hypotension but reduced the volume of the preload required before spinal anaesthesia. Trail registration: The trial was registered with the Chinese Clinical Trial Registry at chictr.org.cn (registration number, ChiCTR2100055050) on December 31, 2021.
Transcendental entire solutions of quadratic functional equations
Authors: Basir Molla Basir Ahamed , Sanju Sanju mandal 
Published: October 2022

Abstract
Solving Fermat-type functional equations is long standing problems in function theory and it is well-known that ƒ2 + g2 = 1 and ƒ2 + 2αƒg + g2 = 1 are respectively called binomial and trinomial quadratic equations. Using Nevanlinna theory as a tool, in this paper, we study existence and precise form of the solutions general quadratic functional equations aƒ2+2αƒg+bg2+2βƒ+2γg+C = 0. Moreover, we give an answer to a conjecture posed by Zhang. In addition, we obtain a result on the existence of meromorphic solutions to Fermat-type difference equations considering polynomial coefficients, which generalizes an existence result.
Mathematics Subject Classification (2010). 39B32, 30D35.
A machine learning model that identifies neoantigen-reactive CD8+ T cells in human gastrointestinal cancer
Authors: Shi Zhiwen 
Published: October 2022

Abstract
It appears that tumor-infiltrating neoantigen-reactive CD8 + T cells are the primary driver of immune responses to gastrointestinal cancer in patients. By mapping neoantigen-reactive T cells from the single-cell transcriptomes of thousands of tumor-infiltrating lymphocytes, we developed a 26-gene machine learning model for the identification of neoantigen-reactive T cells. In both training and test sets, the model performed admirably. We discovered, by applying the model to large-scale single-cell sequencing data of tumor-infiltrating CD8 + T cells, that Neo T cells exhibited a hyperexpanded phenotype and two distinct differentiation pathways. Moreover, compared to non-neoantigen-reactive T cells, the majority of neoantigen-reactive T cells exhibited notable differences in the biological processes of locomotion and amide metabolism. The analysis of potential cell-to-cell interactions revealed that neoantigen-reactive T cells contain potent signaling molecules, such as CXCL13 and LTA, associated with the formation of tertiary lymphoid structures. This method expedites the identification of neoantigen-reactive TCRs and the engineering of neoantigen-reactive T cells for therapy.
An information-theoretic study of rainfall time series through the Dempster–Shafer approach over a meteorological subdivision of India
Authors: Devi Rashmi Rekha , Chattopadhyay Surajit 
Published: October 2022

Abstract
The present paper reports a study, where we have developed a methodology to understand the relative uncertainty associated with the rainfall amount corresponding to summer monsoon (JJAS) and post monsoon (OND) for the period 1871–2016 over northeast India. After calculating the partial correlation between two random variables after the removal of the effect of the third one, we have standardized all the realizations of the random variables. Subsequently, after applying the Dempster–Shafer theory, we have obtained joint basic assignments through two judging criteria for the fuzzy sets representing the closeness of the observed values to two measures of central tendency for different window sizes obtained from the original time series. The study revealed a higher rate of increase in the uncertainty with a change in the window size for OND than in the case of JJAS. This study finally concluded that this approach could generate some idea about the most advantageous ratio of training and test cases for predictive models with supervised learning procedures.
Use of rivers' water, inadequate hygiene, and sanitation as exposure of internally displaced persons (IDPs) to urogenital schistosomiasis and soil-transmitted helminthiasis in Jalingo Local Government Area (LGA), Taraba State, Nigeria
Authors: Binga Wama Emmanuel , Houmsou Robert Soumay , Garba Liatu Columbus , Amuta Elizabeth Une , Santaya Kela Larit 
Published: October 2022

Abstract
Water- and soil-transmitted helminthiasis in relation to socio-demographic status and risk factors of internally displaced persons in Jalingo Local Government Area (LGA) were determined. The nutritional status was also studied among infected individuals. Urine filtration and Kato-Katz techniques were used to examine urine and faecal samples, respectively. Urogenital schistosomiasis infection was found at a moderate level of 52 (17.6%), whereas ascariasis and hookworm infection were 48 (16.3%) and 8 (2.7%), respectively. Participants in Jauro Gbadi camp as well as the age group (41–50) years significantly had the highest infection with hookworm, 8 (8.2%) (χ2 = 16.70; p = 0.000) and 2 (11.7%)(χ2 = 17.59, p = 0.003), respectively. Farmers were significantly infected with urogenital schistosomiasis (20.1%) (χ2 = 14.03; p = 0.043). Fishing in rivers exposed individuals to urogenital schistosomiasis with an adjusted odds ratio (aOR) = 8.60 (95% CI: 0.86–85.52; p = 0.046). The lack of hygienic measures exposed individuals who ‘don't wash their hands before eating’ to soil-transmitted helminthiasis with an aOR = 4.13 (95% CI: 0.77–21.99; p = 0.045). In sanitation, individuals who ‘don't use pit latrines and do use the bush for defaecating’ were exposed to soil-transmitted helminthiasis with an aOR = 2.14 (95% CI: 1.30–3.52; p = 0.002). Farmers were infected with urogenital schistosomiasis. Participants in the Jauro Gbadi camp and individuals within the age group (41–50) years had high hookworm infection. Use of river water, inappropriate hygiene, and sanitation exposed individuals to infection.