bluuebunny/crossref_metadata_2025_split huggingface dataset:
A composite indicator of derived neutrophil–lymphocyte ratio and lactate dehydrogenase correlates with outcomes in pancreatic carcinoma patients treated with PD-1 inhibitors
Authors: Chen Shiyun , Guo Shiyuan , Gou Miaomiao , Pan Yuting , Fan Mengjiao , Zhang Nan , Tan Zhaoli , Dai Guanghai 
Published: October 2022

BackgroundThere are currently no established biomarkers that can predict whether advanced pancreatic carcinoma (PC) patients would benefit from immune checkpoint inhibitors (ICIs). Our study investigated whether the pretreatment composite biomarker of derived neutrophil–lymphocyte ratio (dNLR) and lactate dehydrogenase (LDH) can be used as a reliable prognostic factor for the survival of PC patients receiving PD-1 inhibitor therapy.MethodsPatients with advanced PC treated with PD-1 inhibitors at a single center from September 2015 to September 2020 were included. The high levels of dNLR (≥3) and LDH (≥250 U/L) were considered to be risk factors. Based on these two risk factors, patients in this study were categorized into two risk groups: the good dNLR-LDH group, without risk factors, and the intermediate/poor dNLR-LDH group, with one to two risk factors. Overall survival (OS) and progression-free survival (PFS) served as this study’s primary and secondary endpoints. Cox regression models were used to identify independent prognostic factors for survival benefit.ResultsThere were 98 patients in our study. The good group included 61 (62.2%) patients and the intermediate/poor group included 37 (37.8%). The overall patients with PC who received immunotherapy had a median OS of 12.1 months, and the good dNLR-LDH group had a significantly longer OS compared with the intermediate/poor dNLR-LDH group (44.2 vs. 6.4 months; p &lt; 0.010); median PFS was 3.7 and 2.5 months (p = 0.010). The number of metastatic sites &gt;2 and immunotherapy as third-line or later was associated with worse PFS, and the line of immunotherapy and the dNLR-LDH indicator were independent prognostic factors for OS, according to multivariate analysis.ConclusionThe pretreatment composite biomarker of dNLR and LDH can be used as a prognostic biomarker in patients with advanced PC treated with PD-1 inhibitors.
Consistency of recommendations for pharmacotherapy of rheumatoid arthritis
Authors: Hu Yue , Han Yunze , Ma Yan , Fan Shumei , Wang Xue , Fu Xinyu , Hu Xiaopeng , Luo Xufei , Ma Yanfang , Xun Yangqin , Yang Nan , Wen Chengping , Cao Wei , Song Xuping , Chen Yaolong 
Published: October 2022

Background: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory arthropathy. Recommendations for RA, specifically on pharmacotherapy, are essential in clinical practice. However, the direction and strength of recommendations are controversial across current clinical practice guidelines (CPGs) of RA.Objective: To systematically analyze the consistency of recommendations regarding pharmacotherapy of RA across CPGs.Methods: 11 electronic databases and websites were comprehensively searched from inception to 14 March 2022, to identify CPGs for diagnosis, therapy, and management of RA. Unambiguous and discrete specifications of the population-intervention-comparison (PIC) framework were used to classify the recommendations. Based on the PIC framework, consistency analyses across CPGs on pharmacotherapy of RA were performed. Two researchers reached a consensus on coding the direction and strength of each recommendation.Results: Finally, 26 CPGs were included in this study, and 14 of them, which included pharmacotherapy, were performed consistency analysis. 1) 64 recommendations from 14 CPGs were classified into 18 PICs. 2) Seven PICs (38%) were consistent in direction and strength, 10 PICs (56%) were consistent in direction but inconsistent in strength, and one PIC (6%) was inconsistent in direction (hydroxychloroquine, HCQ). 3) Sensitivity analysis tested the robustness, and the inconsistency remained high.Conclusion: The direction was highly consistent among the recommendations of pharmacotherapy for RA, but the strength was highly inconsistent. Reasons for the inconsistency need to be further investigated, and consistent recommendations could guide the pharmacotherapy of RA in clinical practice.
Mean-field simulations of Es-254 + Ca-48 heavy-ion reactions
Authors: Stevenson Paul D. 
Published: October 2022

Einstenium-254 (Z = 99, N = 155), can be prepared as a target for research into nuclear reaction studies. This work presents structure and reaction calculations of Es-254 and Ca-48 (Z = 20, N = 28), using the Skyrme-(Time-Dependent)-Energy-Density-Functional formalism. The reaction calculations show the initial parts of the heavy-ion reaction between the nuclei which, depending on the interaction parameters, can lead to capture to a compound nucleus of element 119. For collisions with the spherical 48Ca impinging on the tip of the prolate 254Es no fusion events are found. For collisions where the calcium approaches the belly of the einsteinium, capture occurs with the compound nucleus outlasting the lifetime of the calculation, indicating a possible fusion candidate. For a sample center-of-mass collision energy of 220 MeV, slightly non-central collisions, up to an impact parameter of 1 fm, also form long-lived compound nuclei.
All-polarization-maintaining fiber optical frequency comb for the dispersion measurement of a microcavity
Authors: Yanyan Zhang , Pan Zhang , Mingkun Li , Jiazheng Song , Faxi Chen , Libo Li , Xuelong Li , Yuanshan Liu 
Published: October 2022

In this research, we demonstrate an optical frequency comb (OFC) based on a figure-9 laser and polarization-maintaining fibers to measure the dispersion of a microcavity. We adopt a multi-branch structure to obtain a broadband spectrum from 1,250 nm to 1,640 nm with 6-dB bandwidth. The single-mode power at each wavelength of the supercontinuum spectra is greater than 300 nJ, which assures the signal-to-noise ratio of the beat notes between the OFC and the diode laser. The frequency stability of the repetition rate is about 7.5 × 10–14 in an integration time of 1 s. This system allows us to extend the measurement bandwidth to 60 THz at the sub-megahertz resolution, which meets the requirements of the microcavity’s higher-order dispersion measurement.
Temperature dependence of dielectric properties of blood at 10 Hz–100 MHz
Authors: Wang Weice , Li Weichen , Liu Benyuan , Wang Lei , Li Kun , Wang Yu , Ji Zhenyu , Xu Canhua , Shi Xuetao 
Published: October 2022

The temperature dependence of the dielectric properties of blood is important for studying the biological effects of electromagnetic fields, electromagnetic protection, disease diagnosis, and treatment. However, owing to the limitations of measurement methods, there are still some uncertainties regarding the temperature characteristics of the dielectric properties of blood at low and medium frequencies. In this study, we designed a composite impedance measurement box with high heat transfer efficiency that allowed for a four/two-electrode measurement method. Four-electrode measurements were carried out at 10 Hz-1 MHz to overcome the influence of electrode polarization, and two-electrode measurements were carried out at 100 Hz-100 MHz to avoid the influence of distribution parameters, and the data was integrated to achieve dielectric measurements at 10 Hz-100 MHz. At the same time, the temperature of fresh blood from rabbits was controlled at 17–39°C in combination with a temperature-controlled water sink. The results showed that the temperature coefficient for the real part of the resistivity of blood remained constant from 10 Hz to 100 kHz (−2.42%/°C) and then gradually decreased to −0.26%/°C. The temperature coefficient of the imaginary part was positive and bimodal from 6.31 kHz to 100 MHz, with peaks of 5.22%/°C and 4.14%/°C at 126 kHz and 39.8 MHz, respectively. Finally, a third-order function model was developed to describe the dielectric spectra at these temperatures, in which the resistivity parameter in each dispersion zone decreased linearly with temperature and each characteristic frequency increased linearly with temperature. The model could estimate the dielectric properties at any frequency and temperature in this range, and the maximum error was less than 1.39%, thus laying the foundation for subsequent studies.
Value-driven career attitude and job performance: An intermediary role of organizational citizenship behavior
Authors: Iqbal Muhammad Babar , Li Jianxun , Yang Shuili , Sindhu Paras 
Published: October 2022

BackgroundValue-driven career attitude (VDCA) is considered a dimension of a protean career attitude (PCA). Individuals with this attitude seek out personally meaningful experiences and set their own psychological career success standards. This study investigates the association between value-driven career attitude and job performance. It looks at how organizational citizenship behavior affects the relationship between value-driven career attitudes and job performance.MethodsA self-reported questionnaire was used to collect data from 400 random employees of SMEs in Pakistan during the early pandemic. We chose Cochran’s formula to determine the appropriate sample size, and PLS-SEM was used to analyze the model. P-O fit and self-determination theory is the theoretical lenses used in this study. The underpinning theories to this study enable the researchers to establish a link between VDCA, OCB, and job performance.ResultsBy analyzing a sample of 400 employees from active enterprises, we discover that VDCA contributes to an improvement in job performance. Furthermore, OCB plays an intervening effect in the relationship between VDCA and job performance. Thus, the study provided evidence for the underpinning models of P-O fit and self-determination theory.ConclusionThis study adds to the body of knowledge by investigating the connections between VDCA, OCB, and job performance in SMEs. The existing literature sheds scant light on these linkages, leaving a gap that this study will address. The current study expands on other themes to provide an in-depth analysis of many under-explored PCA outcomes, which may open up new avenues for future researchers to broaden and strengthen PCA with other constructs.
Study on lifestyle habits affecting sleep disorders at the undergraduate education stage in Xuzhou City, China
Authors: Wu Qi , Yuan Lei , Guo Xiao-Han , Li Jia-An , Yin Dehui 
Published: October 2022

BackgroundIn China, undergraduate students face both academic and career selection pressures, sleep is an important physiological process for them. Investigate the physical exercise, sleep quality of undergraduate students in the education stage in Xuzhou City, and analyze the factors affecting their sleep quality, to promote the health education and psychological health of undergraduate students.Materials and methodsThe Physical Activity Rating Scale-3 (PARS-3), the Pittsburgh Sleep Quality Index (PSQI), and the demographic information questionnaire were used to survey a whole-group sample of four undergraduate colleges and universities (Xuzhou Institute of Engineering, Xuzhou Medical University, China University of Mining and Technology, Jiangsu Normal University) in Xuzhou by cluster sampling, the general characteristics including gender, grade, height, weight, domicile, race, economic income, etc., were collected, and the data were analyzed and processed using chi-square tests and multi-factor logistic regression.Results3,366 valid questionnaires were collected from four undergraduate colleges and universities, including 1,355 males and 2,011 females. The detection rate of exercise in Jiangsu Normal University was lower than that in other universities, and the detection rate of sleep disorders was higher than that in other universities. Xuzhou Medical University, the highest detection rate of large exercise, Xuzhou Institute of Technology, the lowest detection rate of sleep disorders. There were significant differences in the detection rate of large amount of exercise among college students of different genders, grades, body types, and majors (χ2 = 259.172, P &lt; 0.001; χ2 = 34.473, P &lt; 0.001; χ2 = 36.026, P &lt; 0.001; χ2 = 57.908, P &lt; 0.001). There were significant differences in the detection rate of sleep disorders among college students with different gender, grade, family economic status, daily cell phone use time, cell phone purposeless usage, and exercise level (χ2 = 5.806, P = 0.016; χ2 = 47.5, P &lt; 0.001; χ2 = 28.949, P &lt; 0.001; χ2 = 55.866, P &lt; 0.001; χ2 = 147.101, P &lt; 0.001; χ2 = 9.129, P = 0.010). Multivariate logistic regression analysis showed that grade, family economic status, cell phone use time, cell phone purposeless usage is the main influencing factors of sleep disorders in college students.ConclusionThe sleep problems of undergraduates are serious, especially in Jiangsu Normal University. Scientific and appropriate exercise is an important measure to solve the sleep problems of undergraduates. Colleges and universities should actively carry out health education, college students living habits such as cell phone use should be guided training.
Virtual leadership in relation to employees' mental health, job satisfaction and perceptions of isolation: A scoping review
Authors: Efimov Ilona , Rohwer Elisabeth , Harth Volker , Mache Stefanie 
Published: October 2022

BackgroundThe significant increase of digital collaboration, driven by the current COVID-19 pandemic, is resulting in changes in working conditions and associated changes in the stress-strain perception of employees. Due to the evident leadership influence on employees' health and well-being in traditional work settings, there is a need to investigate leadership in virtual remote work contexts as well. The objective of this scoping review was to assess the extent and type of evidence concerning virtual leadership in relation to employees' mental health, job satisfaction and perceptions of isolation.MethodA search was undertaken in five databases, PubMed, Cochrane Library, PsycINFO, PSYNDEX and Web of Science, as well as reference lists of included articles on 9th February 2021 and an update on 28th September 2021. The search strategy was limited to English, German and French language, peer reviewed journal articles published from January 2000 onwards. This scoping review was conducted in accordance with the JBI methodology for scoping reviews. The methodological quality of the included studies was assessed using the JBI critical appraisal tools. A narrative synthesis was conducted.ResultsNineteen studies met the eligibility criteria for this review. Overarching review findings suggested a positive link between virtual leadership and well-being, job satisfaction, and a negative link to psychological strain, stress and perceptions of isolation of digitally collaborating employees.ConclusionsBy mapping the available evidence on virtual leadership in relation to health and work-related employee outcomes, the review identified many research gaps in terms of content and methodology. Due to limited data, causal relationships were not derived. Future research is needed to examine the complex cause-and-effect relationships of virtual leadership in more detail.
The nature and content of rumination for head and neck cancer survivors
Authors: Menger Fiona , Deane Jennifer , Patterson Joanne M. , Fisher Peter , O’Hara James , Sharp Linda 
Published: October 2022

IntroductionHead and neck cancer (HNC) diagnosis and treatment can be a significant life trauma. Some HNC survivors experience post-traumatic growth (PTG), which has been linked with better health-related quality-of-life. Empirical research on PTG, and theoretical models, point to the importance of being able to purposely make sense of the traumatic experience. Intrusive rumination, by contrast, is linked to poorer outcomes. This study explored HNC survivors’ experiences of rumination.MethodsTwenty HNC survivors between 9 months and 5 years post-diagnosis were recruited (11 male, 9 female, age range 46–83). They had a range of HNC sub-types and cancer treatments. Participants underwent a semi-structured interview about their cancer diagnosis and treatment. Reflexive thematic analysis identified themes and sub-themes around rumination.ResultsFour themes with linked subthemes on the content and process of rumination were identified. Theme 1 was rumination and worry related to diagnosis. Here, survivors discussed how the HNC diagnosis and plans for treatment had dominated their initial thoughts. Theme 2 was processing the trauma of HNC. This theme reflected rumination on the traumatic experience of diagnosis and treatment and how the participant was reacting to it. Theme 3 was considering the impact. This theme encompassed retrospective thinking (e.g., on treatment decisions made) and comparisons between the participant now versus the early days after diagnosis. Theme 4 was continued rumination. This theme included ongoing intrusive and distressing rumination about the trauma and impact of cancer. Those who expressed ongoing rumination revisited fears (e.g., concerns about their future) or returned to negative experiences (e.g., distressing exchanges with healthcare professionals or what they perceived as poor care).ConclusionThis study uniquely describes the nature and content of rumination following HNC. Early intrusive rumination is common and may reflect perceptions of cancer as an existential threat. Over time, rumination can become more reflective and move towards deliberate meaning-making. Some HNC survivors may benefit from interventions to reduce barriers to this transition. The content of distressing and difficult to control rumination (commonly focused on ongoing fears or inability to resolve difficult experiences) helps to identify those who may benefit from more directed psychological support.
Preliminary evidence of links between ayahuasca use and the corpus callosum
Authors: Simonsson Otto , Bouso José Carlos , Kurth Florian , Araújo Dráulio B. , Gaser Christian , Riba Jordi , Luders Eileen 
Published: October 2022

BackgroundRecent research suggests that ayahuasca and its alkaloid-containing ingredients may be helpful in the treatment and prevention of certain movement and neurodegenerative disorders. However, such research is still in its infancy and more studies in normative samples seem necessary to explore effects of ayahuasca on clinically relevant brain structures, such as the corpus callosum.AimsThe purpose of the present study was to investigate links between ayahuasca use and callosal structure in a normative sample.MethodsUsing structural imaging data from 22 ayahuasca users and 22 matched controls we compared the thickness of the corpus callosum between both groups at 100 equidistant points across the entire midsagittal surface. In addition, we investigated point-wise correlations between callosal thickness and the number of past ayahuasca sessions.ResultsThe corpus callosum was significantly thicker within the isthmus in the ayahuasca group than in the control group. There was also a significant positive correlation between callosal thickness and the number of past ayahuasca sessions within the rostral body, albeit none of these effects survived corrections for multiple comparisons. No region was significantly thicker in the control than in the ayahuasca group, and no callosal region was negatively linked to ayahuasca use, even at uncorrected significance thresholds.ConclusionThis study provides preliminary evidence of links between ayahuasca use and the corpus callosum. However, future studies need to replicate these findings, preferably using larger sample sizes and ideally also utilizing longitudinal research designs, to draw any practical conclusion and offer implications for follow-up clinical research.
Supply of basic necessities to vulnerable populations during the COVID-19 pandemic: Empirical evidence from Shanghai, China
Authors: Wang Qian , Dai Ruiming , Zhang Tiantian , Li Jiaru , Sheng Tao , Wu Bin 
Published: October 2022

BackgroundIn spite of initial widespread skepticism, city lockdown has been proved to be an effective short-term tool in containing and delaying the spread of a viral epidemic. The measures to ensure the supply of the basic necessities adequately and equitably, especially for those vulnerable ones has become a major challenge faced by all countries taking a city lockdown measure during the epidemic.MethodsData was collected through relevant government documents, work records, policy reports, media reports and the online-work information platform designed by the research group. Based on these references, the study analyzed the mainly technical difficulties and the countermeasures of the supply process, and summarized the key characteristics of basic necessities supply strategy for vulnerable groups in Shanghai.ResultsThe supply strategy for vulnerable groups in Shanghai covers 16 districts, 232 streets and 6,028 neighborhood communities, which has already been in test running in April in some districts. The practical experience in Shanghai solved three key materials supply problems (lack of purchase channels, insufficient material reserves, insufficient transportation capacity) faced by government during the city lockdown, and showed three essential characteristics (overall coordination, community-centered intervention, technical support).ConclusionsThe findings in this study may provide some suggestions to other countries about how to better manage the preparation, dispatch and transportation of basic necessities in shortage for those vulnerable ones during the city lockdown.
Adverse events following immunization of COVID-19 vaccine among children aged 6–11 years
Authors: Puspitarani Fitriana , Sitaresmi Mei Neni , Ahmad Riris Andono 
Published: October 2022

IntroductionStarting in December 2021, the Indonesian Government has recommended inactivated SARS-CoV-2 vaccine (CoronaVac) for children aged 6–11 years. This study aims to determine the prevalence and determinant factors of adverse events following immunization (AEFI) of the first dose and the second dose of the COVID-19 vaccine among children aged 6–11 years old.Materials and methodsWe conducted a cross-sectional study in Bantul District, Yogyakarta, Indonesia, in February–March 2022. Data were collected by trained interviews with 1,093 parents of children 6–11 years old who received the first dose and the second dose of the COVID-19 vaccine. Data were analyzed with chi-square and logistic regression.ResultsThe prevalence of AEFI in the first dose of the COVID-19 vaccine was 16.7%, while the second dose was 22.6%. The most common symptoms of AEFI at the first dose were local site pain and fever, while at the second dose were cough and cold. Determinants of AEFI of COVID-19 vaccination among children were girls with OR 1.31 (95% CI 1.0–1.7; P 0.04), mass-setting of vaccination with OR 0.70 (95% CI 0.5–0.9; P 0.01), the history of AEFI in childhood vaccination with OR 1.63 (95% CI 1.2–2.2; P &lt; 0.01) and administering other vaccines within 1 month before COVID-19 vaccination, with OR 5.10 (95% CI 2.1–12.3 P &lt; 0.01).ConclusionThe prevalence of AEFI in the first and the second dose of inactivated COVID-19 vaccine was comparable to that reported in the clinical trial study and the communities. Risk communication should be provided to the child and their parents regarding the risk of mild AEFI of the COVID-19 vaccine, especially for children with a history of AEFI in childhood vaccination and who received other vaccines containing the same adjuvant with CoronaVac within 1 month. A mass-setting of vaccination should be taken as an advantage to educate parents about the risk of AEFI and also about the reporting pathways.