bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of NMR-based circulating metabolic biomarkers in development and risk prediction of new onset type 2 diabetes
Authors: Bragg Fiona , Kartsonaki Christiana , Guo Yu , Holmes Michael , Du Huaidong , Yu Canqing , Pei Pei , Yang Ling , Jin Donghui , Chen Yiping , Schmidt Dan , Avery Daniel , Lv Jun , Chen Junshi , Clarke Robert , Hill Michael R. , Li Liming , Millwood Iona Y. , Chen Zhengming 
Published: September 2022

AbstractAssociations of circulating metabolic biomarkers with type 2 diabetes (T2D) and their added value for risk prediction are uncertain among Chinese adults. A case-cohort study included 882 T2D cases diagnosed during 8-years’ follow-up and a subcohort of 789 participants. NMR-metabolomic profiling quantified 225 plasma biomarkers in stored samples taken at recruitment into the study. Cox regression yielded adjusted hazard ratios (HRs) for T2D associated with individual biomarkers, with a set of biomarkers incorporated into an established T2D risk prediction model to assess improvement in discriminatory ability. Mean baseline BMI (SD) was higher in T2D cases than in the subcohort (25.7 [3.6] vs. 23.9 [3.6] kg/m2). Overall, 163 biomarkers were significantly and independently associated with T2D at false discovery rate (FDR) controlled p < 0.05, and 138 at FDR-controlled p < 0.01. Branched chain amino acids (BCAA), apolipoprotein B/apolipoprotein A1, triglycerides in VLDL and medium and small HDL particles, and VLDL particle size were strongly positively associated with T2D (HRs 1.74–2.36 per 1 SD, p < 0.001). HDL particle size, cholesterol concentration in larger HDL particles and docosahexaenoic acid levels were strongly inversely associated with T2D (HRs 0.43–0.48, p < 0.001). With additional adjustment for plasma glucose, most associations (n = 147 and n = 129 at p < 0.05 and p < 0.01, respectively) remained significant. HRs appeared more extreme among more centrally adipose participants for apolipoprotein B/apolipoprotein A1, BCAA, HDL particle size and docosahexaenoic acid (p for heterogeneity ≤ 0.05). Addition of 31 selected biomarkers to an established T2D risk prediction model modestly, but significantly, improved risk discrimination (c-statistic 0.86 to 0.91, p < 0.001). In relatively lean Chinese adults, diverse metabolic biomarkers are associated with future risk of T2D and can help improve established risk prediction models.
Highly sensitive characterization of non-human glycan structures of monoclonal antibody drugs utilizing tandem mass spectrometry
Authors: She Yi-Min , Dai Shaojun , Tam Roger Y. 
Published: September 2022

AbstractGlycosylation is an important attribute of monoclonal antibodies (mAbs) for assessing manufacturing quality. Analysis of non-human glycans containing terminal galactose-α1,3-galactose and N-glycolylneuraminic acid is essential due to the potential immunogenicity and insufficient efficacy caused by mAb expression in non-human mammalian cells. Using parallel sequencing of isobaric glycopeptides and isomeric glycans that were separated by reversed-phase and porous graphitic carbon LC, we report a highly sensitive LC MS/MS method for the comprehensive characterization of low-abundance non-human glycans and their closely related structural isomers. We demonstrate that the straightforward use of high-abundance diagnostic ions and complementary fragments under the positive ionization low-energy collision-induced dissociation is a universal approach to rapidly discriminate branch-linkage structures of biantennary glycans. Our findings reveal the structural diversity of non-human glycans and sulfation of α-galactosylated glycans, providing both an analytical method and candidate structures that could potentially be used in the crucial quality control of therapeutic mAb products.
Molecular pathogenesis of desmoid tumor and the role of γ-secretase inhibition
Authors: Federman Noah 
Published: September 2022

AbstractDesmoid tumor (DT) is a rare, soft tissue neoplasm associated with an unpredictable clinical course. Although lacking metastatic potential, DT is often locally aggressive and invasive, causing significant morbidity. Both sporadic DT and familial adenomatous polyposis (FAP)-associated DT are linked to constitutive activation of the Wnt signaling pathway with mutations in the β-catenin oncogeneCTNNB1or the tumor suppressor geneAPC, respectively. Cross-talk between the Notch and Wnt pathways, as well as activation of the Notch pathway resulting from dysregulation of the Wnt pathway, suggest a possible therapeutic target for DT. Due to the role γ-secretase plays in Notch signaling through cleavage of the Notch intracellular domain (with subsequent translocation to the nucleus to activate gene transcription), γ-secretase inhibitors (GSIs) have emerged as a potential treatment for DT. Two GSIs, nirogacestat (PF-03084014) and AL102 are in later-stage clinical development; nirogacestat is being evaluated in a phase 3, randomized, placebo-controlled trial while AL102 is being evaluated in a phase 2/3, dose-finding (part A) and placebo-controlled (part B) trial. This review summarizes current understanding of the molecular pathogenesis of DT focusing on dysregulation of the Wnt signaling pathway, crosstalk with the Notch pathway, and the potential therapeutic role for GSIs in DT.
Deep learning framework for multi‐round service bundle recommendation in iterative mashup development
Authors: Ma Yutao , Geng Xiao , Wang Jian , He Keqing , Athanasopoulos Dionysis 
Published: September 2022

AbstractRecent years have witnessed the rapid development of service‐oriented computing technologies. The boom of Web services increases software developers' selection burden in developing new service‐based systems such as mashups. Timely recommending appropriate component services for developers to build new mashups has become a fundamental problem in service‐oriented software engineering. Existing service recommendation approaches are mainly designed for mashup development in the single‐round scenario. It is hard for them to effectively update recommendation results according to developers' requirements and behaviours (e.g. instant service selection). To address this issue, the authors propose a service bundle recommendation framework based on deep learning, DLISR, which aims to capture the interactions among the target mashup to build, selected (component) services, and the following service to recommend. Moreover, an attention mechanism is employed in DLISR to weigh selected services when recommending a candidate service. The authors also design two separate models for learning interactions from the perspectives of content and invocation history, respectively, and a hybrid model called HISR. Experiments on a real‐world dataset indicate that HISR can outperform several state‐of‐the‐art service recommendation methods to develop new mashups iteratively.
Understanding dust production and mass loss in the AGB phase using post-AGB stars in the Magellanic Clouds
Authors: Tosi S. , Dell’Agli F. , Kamath D. , Ventura P. , Van Winckel H. , Marini E. 
Published: September 2022

Context. The asymptotic giant branch (AGB) phase of evolution in low- and intermediate-mass stars is governed by poorly understood physical mechanisms, such as convection, mixing, dust production and mass loss, which play a crucial role in determining the internal structure and the evolution of these stars. The spectra of post-asymptotic giant branch (post-AGB) stars hold critical chemical fingerprints that serve as exquisite tracers of the evolution, nucleosynthesis, and dust production during the AGB phase.
Aims. We aim to understand the variation in the surface chemistry that occurs during the AGB phase by analysing results from observations of single post-AGB stars in the Magellanic Clouds. We also aim to reconstruct dust-formation processes, which are active in the circumstellar envelope of AGB stars, occurring towards the end of the AGB phase and during the subsequent course of evolution when contraction to the post-AGB has begun.
Methods. We study likely single post-AGB sources in the Magellanic Clouds that exhibit a double-peaked (shell-type) spectral energy distribution (SED). We interpret their SED by comparing with results from radiative transfer calculations to derive the luminosity and the dust content of the individual sources. Additionally, we compare the observationally derived stellar parameters and the photospheric chemical abundances of the target sample with results from stellar evolution modelling of AGB and post-AGB stars. This allows for the characterization of the individual sources in terms of the initial mass and formation epoch of the progenitors. The theoretically derived dust mineralogy and optical depth is used to assess when dust formation ceases and to determine the propagation velocity of the dust-gas system during post-AGB evolution.
Results. We find that amongst our target sample of 13 likely single post-AGB stars with shell-type SED, eight objects are carbon stars descending from ∼1−2.5 M⊙ progenitors. Five of the 13 objects are of lower mass, descending from M < 1 M⊙ stars. Based on the dust mineralogy, we find that these five stars are surrounded by silicate dust, and thus failed to become carbon stars. The dust optical depth and the luminosity of the stars are correlated, owing to the faster evolutionary timescale of brighter stars, which makes the dusty layer closer to the central object. From our detailed analysis of the SEDs, we deduce that the dust currently observed around post-AGB stars was released after the onset of the central star contraction and an increase in the effective temperature to ∼3500−4000 K.
Sexualbezogene Online-Fortbildung für Fachkräfte: TikTok
Authors: Döring Nicola 
Published: September 2022

ZusammenfassungDer vorliegende Praxisbeitrag befasst sich mit der Kurzvideoplattform TikTok. Er beschreibt die Funktionsweise der Plattform und geht auf den bisherigen Stand der TikTok-Forschung ein. Im Fokus stehen dann Sexualaufklärung, LGBTIQ + sowie Beziehungs- und Datingberatung auf TikTok.
Doppelstöckige Rindertransporte und die Grenzen des Tierschutzes
Authors: Schimanski Michael , Franzky Andreas , Herzog Kathrin 
Published: September 2022

ZusammenfassungDoppelstöckige Rindertransporte werden regelmäßig innerstaatlich, EU-weit und in Nicht-EU-Staaten durchgeführt. Dabei sind sehr lange Transporte von einer Woche und mehr keine Seltenheit. Insbesondere bei ausgewachsenen Deutsch-Holstein Rindern ist ein doppelstöckiger Transport problematisch, da die Tiere aufgrund ihrer Größe immer seltener unter Wahrung der tierschutzrechtlichen Vorgaben verladen werden können.Aufgrund ihrer Größe können Rinder mit dem Kopf oder dem Rücken mit den Dach- oder Zwischenbodenkonstruktionen in Kontakt kommen und sich dabei verletzen. Gemäß der europäischen Tierschutztransportverordnung darf eine Tierbeförderung nicht durchgeführt oder veranlasst werden, wenn den Tieren dabei Verletzungen oder unnötige Leiden zugefügt werden. Sowohl die europäische als auch die nationale Tierschutztransportverordnung bilden das Regelwerk tierschutzrechtlicher Vorgaben zur gewerbsmäßigen Beförderung von Tieren. Die Platzvorgaben über den Tieren (sog. „Rückenfreiheit“) sind nicht eindeutig im Verordnungstext geregelt, weshalb die Europäische Kommission in einer angeforderten Konkretisierung 2011 bei Rindern eine „Rückenfreiheit“ von mind. 20 cm über dem Widerrist des größten Tieres als erforderlich ansieht.Dieser Artikel soll einen Überblick über die Tierschutzproblematik der doppelstöckigen Beförderung von Rindern geben und aktuell mögliche Lösungsansätze aufzeigen.
Divergierende Konzeptionen sexueller Funktionsstörungen in DSM-5 und ICD-11: Konsequenzen für die Diagnostik, Forschung und Praxis
Authors: Schwesig Rebekka , Briken Peer , Velten Julia , Hoyer Jürgen 
Published: September 2022

Zusammenfassung
Einleitung Obwohl in vielen Bereichen psychischer Störungen in den letzten Jahrzehnten eine Harmonisierung der Diagnosekategorien gemäß DSM-5 und ICD-11 erreicht wurde, gilt dies für den Bereich der sexuellen Funktionsstörungen nicht.
Forschungsziele Anliegen dieser Übersicht ist ein Vergleich der Konzeptionen sexueller Funktionsstörungen in der ICD-11 und im DSM-5. In einem zweiten Schritt sollen Vor- und Nachteile beider Konzeptionen sowie deren Konsequenzen für die Diagnostik, Forschung und Praxis untersucht und kritisch diskutiert werden.
Methoden Die Konzeptionen und diagnostischen Entscheidungsregeln sexueller Funktionsstörungen in den zwei Klassifikationssystemen werden gegenübergestellt und hinsichtlich der Gemeinsamkeiten und Unterschiede auf Symptom- und Störungsebene untersucht.
Ergebnisse In der ICD-11 werden die sexuellen Funktionsstörungen nicht mehr den psychischen Störungen zugeordnet, sondern in einem neunen Kapitel „Conditions related to sexual health“ verortet. Während sich ICD-11 und DSM-5 in ihren Störungs- und Symptombeschreibungen deutlich angenähert haben, unterscheiden sie sich nun fundamental in ihrem Umgang hinsichtlich der Ätiologie sexueller Funktionsstörungen: Dem neuen integrativen, multifaktoriellen, (in Bezug auf die Diagnosevergabe) nicht-ätiologischen Ansatz der ICD-11 (bei dem aber gleichzeitig eine Ätiologie benannt werden kann) steht der ausschließlich psychische, Ätiologie-geleitete Ansatz des DSM-5 entgegen, der zum Ziel hat, sexuelle Funktionsstörungen isoliert als psychische Störungen zu definieren.
Schlussfolgerung Die Unterschiede in der Konzeption sexueller Funktionsstörungen erschweren die internationale Kommunikation und Forschungszusammenarbeit maßgeblich und sind auch für die Anwendungspraxis mit erheblichen Konsequenzen verbunden. Eine einheitliche Klassifikation sexueller Funktionsstörungen wäre daher wünschenswert. Dies scheint aber auch in Zukunft – aufgrund der unterschiedlichen Prioritäten und Zielgruppen der Weltgesundheitsorganisation und der American Psychiatric Association – nicht sehr wahrscheinlich.
Successful treatment of coagulation disorders and hypoalbuminaemia in a puppy with Infectious Canine Hepatitis
Authors: Polovitzer Julia , Guija-De-Arespacochaga Abigail , Auer Angelika , Künzel Frank 
Published: September 2022

AbstractDue to high vaccination coverage of the dog population in Western and Middle Europe, veterinarians are usually not familiar with clinical signs and treatment of Infectious Canine Hepatitis (ICH). This case report describes a 4-month-old female mixed breed dog that was imported from Bulgaria. According to the history, the puppy was presented with lethargy, pyrexia, icterus and melaena. On clinical examination, the dog additionally exhibited a painful abdomen and bleeding tendency at the venous puncture sites. Blood analysis revealed anaemia, left shift without leucocytosis, increased liver enzymes and prolonged coagulation times. Polymerase Chain Reaction (PCR) and subsequently sequence analysis performed out of urine confirmed Canine Adenovirus 1 (CAV-1) as the causative agent of the disease. Peripheral oedema developed on the dog´s head and limbs during the progression of the disease due to severe hypoalbuminaemia. Initial treatment of the puppy included transfusion of whole blood and fresh frozen plasma. Hypoalbuminaemia was treated by transfusion using human albumin. On day eight after starting the treatment, the dog was released from the hospital due to an unremarkable clinically condition. This case report indicates that ICH might become a re-emerging disease by means of rising dog imports. Especially, the severe form of ICH can be associated with several life-threatening complications that require hospitalisation and intensive care treatment.
Comparison of Cervical Joint Position Sense in Computer Users with Neck Pain, Forward Head Posture, Asymptomatic and Non-Computer Users – A Cross-Sectional Study
Authors: Reddy Ravi Shankar , Alshahrani Mastour Saeed , Tedla Jaya Shankar , Dixit Snehil , Asiri Faisal , Lafi Al-Otaibi Mohammed , Kakaraparthi Venkata Nagaraj , Assiri Sultan Mofreh A. 
Published: September 2022

AbstractPurpose People use computers in offices and workplaces daily to perform different activities. Impaired cervical proprioception and forward head posture (FHP) may contribute to the development and maintenance of neck pain in computer users. The aims of this study are 1) to compare cervical joint position sense (JPS) in computer users with neck pain, with FHP, healthy computer users, and healthy non-computer users, 2) to assess the relationship between cervical JPS and age, BMI, pain, disability, head posture, and duration of computer usage.Materials and Methods This cross-sectional study included 134 subjects aged between 25 to 50 years old in four groups (Group 1: computer users with neck pain (n=31), group 2: computer users with FHP (n=33), Group 3: healthy computer users (n=35), and Group 4: healthy non-computer users (n=35). The cervical JPS was evaluated in flexion, extension left and right rotation directions using a cervical range of motion device. The reposition accuracy is estimated as joint position error (JPE) in degrees. The cervical JPS is compared between groups and correlated with age, BMI, pain, disability, head posture, and duration of computer usage.Results and Discussion The mean cervical JPE's were significantly larger in the neck pain group (p<0.001) and in the FHP group (p<0.001) compared to other groups. There were no significant differences in JPE's between healthy computer users and non-users (p.>0.05). There was a significant positive correlation between JPE's and age, pain intensity, disability, and computer usage duration.Conclusion Computer users with neck pain and with FHP had significantly impaired cervical JPS. Factors like FHP, pain intensity, disability, and duration of computer usage may influence cervical JPS, and these factors can be considered when assessing and planning treatment strategies for computer professionals.
Effects of Abacus Training on Auditory Spatial Maturation in Children with Normal Hearing
Authors: Sanjana M. , Nisha K. V. 
Published: September 2022

Abstract
Introduction The spatial auditory system, though developed at birth, attains functional maturity in the late childhood (12 years). Spatial changes during childhood affect navigation in the environment and source segregation. Accommodation of a new skill through learning, especially during childhood, can expedite this process.
Objective To explore the auditory spatial benefits of abacus training on psychoacoustic metrics in children. The study also aimed to identify the most sensitive metric to abacus training related changes in spatial processing, and utilize this metric for a detailed spatial error profiling.
Methods A standard group comparison analysis with 90 participants divided into three groups: I: children with abacus training (C-AT); II: children with no training (C-UT); III: adults with no training (A-UT). The groups underwent a series of psychoacoustic tests, such as interaural time difference (ITD), interaural level difference (ILD), and virtual auditory space identification (VASI), as well as perceptual tests such as the Kannada version of the speech, spatial, and quality questionnaire (K-SSQ).
Results Significant group differences were observed in the multivariate analysis of variance (MANOVA) and post-hoc tests, with the C-AT group showing significantly lower ILD scores (p = 0.01) and significantly higher VASI scores (p<0.001) compared to the C-UT group, which is indicative of better spatial processing abilities in the former group. The discriminant function (DF) analyses showed that the VASI was the most sensitive metric for training-related changes, based on which elaborate error analyses were performed.
Conclusions Despite the physiological limits of the immature neural framework, the performance of the C-AT group was equivalent to that of untrained adults on psychoacoustic tests, which is reflective of the positive role of abacus training in expediting auditory spatial maturation.
The Boundaries of a Small Company’s Human Voice: Insights into Dark Humour in Internet Recruitment Advertising
Authors: Oikarinen Eeva-Liisa 
Published: September 2022

AbstractThis study develops a framework on how a small company's human tone of voice involving dark humour can be communicated in Internet recruitment advertising. A case study approach with an abductive logic provided a synthesis of the different recruitment communication perspectives [sender, message, electronic word-of-mouth (eWOM)] and a dark humour tone of voice used in a small company's Internet recruitment advertising in a holistic framework. The developed framework was able to demonstrate the dynamics related to a tone of voice based on dark humour from different communication perspectives in Internet recruitment advertising, and the process of how the limits for an acceptable human tone of voice are formed. Further, the study proposed a new definition for eWOM in recruitment advertising which included a human tone of voice as a relevant aspect of eWOM. For managers, the boundaries of the human tone of voice, in this case dark humour, should be handled as it might become an irritating employer brand message element and might negatively affect the construction of a positive and consistent employer image.
Physiological noise facilitates multiplexed coding of vibrotactile-like signals in somatosensory cortex
Authors: Kamaleddin Mohammad Amin , Shifman Aaron , Abdollahi Nooshin , Sigal Daniel , Ratté Stéphanie , Prescott Steven A. 
Published: September 2022

Neurons can use different aspects of their spiking to simultaneously represent (multiplex) different features of a stimulus. For example, some pyramidal neurons in primary somatosensory cortex (S1) use the rate and timing of their spikes to, respectively, encode the intensity and frequency of vibrotactile stimuli. Doing so has several requirements. Because they fire at low rates, pyramidal neurons cannot entrain 1:1 with high-frequency (100 to 600 Hz) inputs and, instead, must skip (i.e., not respond to) some stimulus cycles. The proportion of skipped cycles must vary inversely with stimulus intensity for firing rate to encode stimulus intensity. Spikes must phase-lock to the stimulus for spike times (intervals) to encode stimulus frequency, but, in addition, skipping must occur irregularly to avoid aliasing. Using simulations and in vitro experiments in which mouse S1 pyramidal neurons were stimulated with inputs emulating those induced by vibrotactile stimuli, we show that fewer cycles are skipped as stimulus intensity increases, as required for rate coding, and that intrinsic or synaptic noise can induce irregular skipping without disrupting phase locking, as required for temporal coding. This occurs because noise can modulate the reliability without disrupting the precision of spikes evoked by small-amplitude, fast-onset signals. Specifically, in the fluctuation-driven regime associated with sparse spiking, rate and temporal coding are both paradoxically improved by the strong synaptic noise characteristic of the intact cortex. Our results demonstrate that multiplexed coding by S1 pyramidal neurons is not only feasible under in vivo conditions, but that background synaptic noise is actually beneficial.