bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk prediction of cardiovascular disease using machine learning classifiers
Authors: Pal Madhumita , Parija Smita , Panda Ganapati , Dhama Kuldeep , Mohapatra Ranjan K. 
Published: June 2022

Abstract
Cardiovascular disease (CVD) makes our heart and blood vessels dysfunctional and often leads to death or physical paralysis. Therefore, early and automatic detection of CVD can save many human lives. Multiple investigations have been carried out to achieve this objective, but there is still room for improvement in performance and reliability. This study is yet another step in this direction. In this study, two reliable machine learning techniques, multi-layer perceptron (MLP), and K-nearest neighbour (K-NN) have been employed for CVD detection using publicly available University of California Irvine repository data. The performances of the models are optimally increased by removing outliers and attributes having null values. Experimental-based results demonstrate that a higher accuracy in detection of 82.47% and an area-under-the-curve value of 86.41% are obtained using the MLP model, unlike the K-NN model. Therefore, the proposed MLP model was recommended for automatic CVD detection. The proposed methodology can also be employed in detecting other diseases. In addition, the performance of the proposed model can be assessed via other standard data sets.
A More Liberal Public Reason Liberalism
Authors: Fumagalli Roberto 
Published: June 2022

AbstractIn recent years, leading public reason liberals have argued that publicly justifying coercive laws and policies requires that citizens offer both adequate secular justificatory reasons and adequate secular motivating reasons for these laws and policies. In this paper, I provide a critical assessment of these two requirements and argue for two main claims concerning such requirements. First, only some qualified versions of the requirement that citizens offer adequate secular justificatory reasons for coercive laws and policies may be justifiably regarded as plausible liberal principles of public justification. And second, the requirement that citizens offer adequate secular motivating reasons for coercive laws and policies is untenable on multiple grounds. Public reason liberals should focus on assessing the justificatory reasons offered for and against coercive laws and policies rather than requiring citizens to offer adequate secular motivating reasons for such laws and policies.
Intermarine Area Archaeology and its Contribution to Studies of Prehistoric Europe
Authors: Kośko Aleksander , Szmyt Marzena , Makarowicz Przemysław , Ignaczak Marcin 
Published: June 2022

Abstract
Intermarine Area Archaeology refers to research programmes focusing on the prehistory of the Baltic-Pontic Intermarine Area, i.e. lands extending between the Baltic and Black seas. This article outlines the development stages and current state of Intermarine Area Archaeology in Poland, being one of the several important research studies into the prehistory of the continent in the Eneolithic, Bronze, and Early Iron Ages. The authors concentrate on the southern portion of the Intermarine Area that covers the Black Sea catchment area. When describing the current state of the Polish conceptual and research contribution to Intermarine Area Archaeology, space shall be given to the programme offer, formation of international research teams, and research specializations.
Colonists and Natives. The Beginning of the Eneolithic in the Middle Warta Catchment. 4500–3500 BC
Authors: Żurkiewicz Danuta 
Published: June 2022

Abstract
The article presents the history of research and the latest archaeological discoveries of the Greater Poland Neolithic in the Middle Warta River catchment. I propose focusing on new areas of research that have potential but have not yet been conducted. It focuses on two social groups, the Funnel Beaker culture (FBC) and the Brześć Kujawski culture (BKC). The unsatisfactory level of knowledge about the development of these cultural communities in the region may be supplemented by recently conducted research. The discovery and excavation of the first megalithic tombs in Greater Poland, conducted with the help of LiDAR, was of great importance. Following this, more such cemeteries have been located. The re-analysis of previously excavated materials from the site in Kotowo determined that the early phase of FCB occurred around 3700 BC. A fruitful area for future study is the acquisition of unique BKC settlement evidence obtained from the site in Kąkolewo. Another important area that can supplement current understandings of cultural relations in this area is understanding the environmental background, which is to be served by the proposed palaeoenvironmental research, particularly near the cemetery in Sobota. Considering this new information will allow for a proper estimation of the role of Greater Poland in the transmission of cultural patterns that created the image of the Central European Plain in 4500–3500 BC.
Home and Exile – Dancing in the Mess of Contradictions
Authors: Hellsten Laura 
Published: June 2022

AbstractThis is a meta-reflection on the methodological and epistemological challenges of doing ethnographic theology in a context outside the church or religious communities. Particularly, it argues that in a multi- or inter-disciplinary setting theologians are placed in a precarious position when it comes to use of language, theories and concepts if they want to speak simultaneously to the people they encounter in the field and to their “own” scientific community. The article asks how a researcher can do theology in a secular environment without doing violence towards ones interlocutors and still be considered to “belong” in the theological community? Based on the lived experiences of ongoing research and particularly concerning the gathering and telling the stories of Women in the Natural sciences, the author weaves together Eileen Campbell-Reed’s and Sarah Coakley’s methodological frameworks in order to present her own method of contemplative dance. The author uses rich metaphors and the sensory experience of “Home” and “Exile” in relationship to the movements in a foot to bring forth her embodied insights about dancing in the messy entanglement of ethnographic research.
Early creatinine and e-GFR changes as prognostic predictors of COVID-19 patients
Authors: Ahmet Karatas , Ebru Canakci , Emre Erdem , Aykut Ozturan , Yasemin Kaya , Beyza Sayim , Mervegul Kaya 
Published: June 2022

Abstract

Objectives
We aimed to investigate the effects of the COVID-19 disease on kidney functions and early prognosis.

Methods
All cases were divided into those discharged and exitus cases. The patients were diagnosed with acute kidney injury (AKI) according to the KDIGO criteria.

Results
As a result of the ROC analysis, the patients with a creatinine value above 1.05 for day 1 and 0.975 for creatinine value on day 7 would be mortal (AUC values of 0.641 (0.569–0.714) and 0.757 (0.689–0.825), respectively). As a result of Univariate analysis; D-Dimer, Procalcitonin, BUN and creatinine values are risk factors and a one-unit increase in these values is 1.184; 1.105; It was determined that it would increase 1.024 and 1.304 times (p values 0.008; 0.007; <0.001; 0.002), respectively. Decreased in e-GFR value would increase the risk of death 1.026 (1/0.975) times (p<0.001).

Conclusions
We observed the high creatinine, D-dimer, procalcitonin, ferritin, and low e-GFR levels were risk factors for severity and mortality for COVID-19 disease. While physicians and all stakeholders focus on the prognosis and mortality of the disease of COVID-19 disease, it is necessary to be thorough about kidney involvement as much as respiratory system involvement.
Retrospective analysis of the main indicators of Kosiv CRH efficiency for the period 2014–2018
Authors: Stovban Mykola , Tolstanov Alexandr , Kravchenko Oleksiy 
Published: June 2022

This article presents a retrospective analysis relating to the main performance indicators of the Kosovo Central District Hospital (CDH).
The author's method of calculating the efficiency of the hospital on the components of medical, social and economic efficiency is proposed. The reason for the low level of efficiency of the Kosovo CDH is substantiated and ways to increase the efficiency are suggested.
The aim of this article is to conduct a retrospective analysis of the effectiveness of the Kosiv Central District Hospital to identify the main problems of local hospitals and to formulate scientifically sound proposals for improving the medical system in the newly formed united territorial communities.
Research methods. In the article were used general scientific research methods:
Analysis and synthesis, in the study of scientific literature and determining the effectiveness of the Kosiv CDH;
Economic and statistical analysis and comparison, when calculating indicators of medical, social and economic efficiency of the Kosiv CDH,
Generalization - when developing recommendations for improving the efficiency of the Kosiv CDH.
Results: The author's method of calculating indicators for assessing the medical, social, and economic efficiency of the Kosiv CDH was developed.
A retrospective analysis of the effectiveness of the Kosiv CDH was conducted, which allowed us to state the low level of efficiency, which was formed under the influence of factors independent of the hospital itself.
The necessity of introduction of paid medical services and their realization by the Kosiv CDH, development of public-private partnership and the mechanism of acquisition of the diagnostic car for realization of programs on complex diagnostics of health of the population of the Kosiv city united territorial community are substantiated.
Conclusions. A retrospective analysis of the effectiveness of the Kosiv CDH in 2014-2018 allowed us to conclude that the level of such efficiency is quite low. However, the low level of efficiency of the Kosiv CDH is due to the existing principles of medical development in Ukraine, which is, “de jure” based on the concept of free medical care
Comparative study of intrathecal tramadol and fentanyl as adjuvants in lower abdominal surgeries
Authors: Rani H. L. Baby , Rao J. Samba Siva , Vaishnavi G. 
Published: June 2022

Spinal anesthesia is preferred choice of anesthesia in lower abdominal surgeries for a long time. However, the problem with this is limited duration of action, so for long duration surgeries alternatives are required.
The aim: to compare the intra-operative effects of a low dose of intrathecal tramadol and intrathecal fentanyl with hyperbaric bupivacaine hydrochloride.
Materials and methods: prospective randomized control study for a duration of study is one year. 50 patients, aged 18 years to 60 years, belonging to ASA physical status I and II, posted for elective lower abdominal surgeries under spinal anaesthesia were chosen.
These patients were divided into two groups: group BT- this group of patients received 2.5 mL volume of 0.5 % hyperbaric bupivacaine with 25 mg of tramadol intrathecally. Group BF- this group of patients received 2.5 mL volume of 0.5 % hyperbaric bupivacaine with 25 μg of fentanyl intrathecally.
Results: demographic parameters in both the groups are not statistically significant. The association between the differences in duration of surgeries of both the study groups is not statistically. The association between the differences in mean time of onset of sensory block and motor block of both the study groups was comparable with p>0.05
The duration of sensory block (analgesia) and duration of motor block difference between the two means was statistically significant with p<0.0000001. The difference between the mean VAS score at 3 hours and at 20 hours was statistically significant with p<0.05. Among the study BT group, 52 % needed 2 analgesics and 48 % needed 3 doses of analgesics. Among BF group, 6 % needed only one dose of analgesics and 44 % needed 2 doses of analgesics. The difference between the two was statistically significant with p<0.000002. The association between the hemodynamic variables between both the groups at the end of procedure was statistically significant with p<0.05.
Conclusions: Intrathecal fentanyl and tramadol produced a similar onset of sensory and motor blocks. Fentanyl provided better duration and quality of postoperative analgesia compared to tramadol
Water purification from cationic organic dyes using kaolin-based ceramic materials
Authors: Bondarieva Antonina , Yaichenia Iryna , Zahorodniuk Nataliia , Tobilko Viktoriia , Pavlenko Volodymyr 
Published: June 2022

The development of effective sorbents based on cheap natural raw materials for water purification from synthetic organic dyes is an important environmental problem. It is known that layered silicates are distinguished by mechanical strength, thermal and chemical resistance, high dispersion, ion exchange, availability and low cost. However, the main disadvantage of natural clays is their insufficiently high sorption capacity with respect to organic toxicants. Therefore, to increase it, the surface of clay minerals is modified by various physical and chemical methods. The object of study is kaolin from the Glukhovets deposit (Ukraine), the main rock-forming mineral of which is kaolinite. After its thermal modification followed by acid activation with chloride acid, sorbents with sufficiently high structural-sorption properties and increased sorption capacity with respect to the synthetic organic dye, methylene blue, are obtained. The influence of the conditions for the synthesis of ceramic materials on the physicochemical features of the dye removal from the aqueous medium is studied. The dependence of the values of methylene blue sorption by silicate sorbents on the temperature of kaolin treatment and the concentration of chloride acid, which was used for its acid activation, is studied. It has been established that the specific surface of the obtained samples is significantly affected by both the kaolin treatment temperature and the concentration of perchloric acid. Thus, under certain experimental conditions, sorption materials were obtained with a specific surface area of 140 m2/g, which significantly exceeds that for the original kaolin, which is 9 m2/g. A significant increase in the sorption capacity of acid-activated samples compared to the original clay and heat-treated forms was established. The value of the maximum sorption of methylene blue for acid-activated samples exceeds that for natural kaolin by almost 2 times and reaches 16 mg/g.
Study on application of pumpkin seed protein isolate in sausage production process
Authors: Gao Dan , Helikh Anna , Duan Zhenhua , Liu Yan , Shang Feifei 
Published: June 2022

The object of the research is sausage added with pumpkin seed protein isolate. Recently, plant proteins such as soybean protein and peanut protein are widely applied in meat products. Plant proteins have a lower price and less fat than animal meat, which is benefit for human health. Pumpkin seed protein is one of the new plant proteins, which contained balanced amino acids for human beings, was attracted an increasing interest in food industry. In this study, a new type of sausage was developed by single-factor experiments and orthogonal test. According to the single factor results, the added amount of the pumpkin seed protein isolate (1.5 g/100 g, 2.25 g/100 g, 3.0 g/100 g), lean meat (60 g/100 g, 70 g/100 g, 80 g/100 g), cooking time (35 min, 40 min, 45 min), and baking time (2.5 h) were determined to do the orthogonal test. The orthogonal test showed that the addition amount of pumpkin seed protein isolate had the greatest impact on the sausage quality, followed by the cooking time, and the addition amount of lean meat. The optimal production conditions were pumpkin seed protein isolate of 1.5 g/100 g, lean meat of 80 g/100 g, cooking time of 45 min, and baking time of 2.5 h. Under this condition, the sensory score reached 8.5, and the content of moisture, ash, protein, and fat were 51.16 g/100 g, 2.26 g/100 g, 15.22 g/100 g, and 23.15 g/100 g, respectively. This study can provide a fundamental knowledge for the application of pumpkin seed protein isolate in sausages.
Development of innovative model of regional management of freshwater resources in conditions of sustainable development
Authors: Serbov Mykola 
Published: June 2022

In this paper, the object of research is an innovative model of regional management of freshwater resources in the context of achieving environmental goals.
The study found that the most problematic issues are the lack of clear criteria and methodological mechanisms in the formation of the basic innovative principles of freshwater resource management in the context of sustainable development.
When solving the problems posed in the work, the methods of analysis and synthesis, comparative comparison and logical generalization were used. On their basis, the analysis of the main principles of adaptation of the world experience of regional management of freshwater resources in the context of the implementation of the European Union Water Framework Directive was carried out and the conceptual foundations for the formation of an innovative model for the management of freshwater resources of territories in the context of sustainable development were developed. A cluster model of a regional innovation-information portal of freshwater resources is proposed, which allows uniting the efforts of public authorities, the population, the public, scientific institutions and business in solving problematic issues related to the ecosystem based on smart technologies in the context of sustainable development. It is determined that for the functioning of the cluster model it is necessary to develop institutional, legislative, regulatory, scientific and innovative, investment support. It is substantiated that the functioning of the cluster model of the regional innovation-information portal of freshwater resources will solve the following problems:
– creation of a unified data bank for monitoring the quality of water resources, the results of scientific and technical activities, business planning and design for the conservation, restoration and purification of water;
– information services in the field of innovation;
– attraction of business representatives to co-financing of innovative projects.
Thanks to the results of the conducted studies, it is possible to more objectively and balanced assess the possible schemes and tools for managing the territory's freshwater resources. The conceptual approach presented in the paper is a rather flexible tool with a free choice of elements of analysis depending on the goals and objects of management.
Use of perampanel in children with refractory epilepsy of genetic aetiology
Authors: Qu Rui , Dai Yuanyuan , Qu Xiangju , Li Yan , Shao Xuejun , Zhou Rui , Zhu Yali , Chen Xuqin 
Published: June 2022

AbstractObjective. Pathogenic mutations in refractory childhood epilepsy are being increasingly discovered. In this study, we analysed the efficacy and tolerability of perampanel as treatment for genetically‐related refractory childhood epilepsy.Methods. This prospective study, conducted in China, included 50 patients with refractory epilepsy of genetic aetiology, who were treated with adjunctive perampanel therapy. Perampanel treatment was considered effective when the seizure frequency was reduced by >50%. Perampanel treatment was evaluated over at least nine months, from January 2020.Results. A total of 184 paediatric patients with refractory epilepsy received addon perampanel therapy, and of these, 128 received treatment for nine months and underwent genetic analysis. Fifty children were identified with pathogenic or likely pathogenic variants. A total of 24 different causative monogenic mutations were found, and the most common causative monogenic variants were observed in the SCN1A gene (n = 15). The mean maximal dose of perampanel was 3.4±1.2 mg/day in responders. The response rates to perampanel in children with genetically‐related refractory epilepsy (n=50) were 68.0%, 58.0%, and 46.0% at three, six and nine months post‐initiation, respectively. Adverse events were reported in 23 patients (46.0%) with genetic aetiology. Somnolence, ataxia, and irritability were the most common adverse events. The response rates to perampanel in children with pathogenic or likely pathogenic variants associated with Dravet syndrome, tuberous sclerosis, mitochondrial encephalopathy with lactic acidosis and stroke‐like episodes, Rett syndrome, and dentatorubral‐pallidoluysian atrophy were high.Significance. A low maintenance dose of perampanel may be effective and welltolerated as adjunctive treatment in children with refractory epilepsy of genetic aetiology.
Âtike bint Abdülmuttalib
Authors: ADIGÜZEL Osman 
Published: June 2022

Hz. Muhammed’in altı halasından biri olan Âtike bint Abdülmuttalib, Mekke’de doğmuş ve Hz. Peygamber’in vefatından sonra ölmüştür. Babası Abdülmuttalib b. Haşim, annesi ise Fatma bint Amr b. Aiz b. İmran b. Mahzûm’dur. Âtike, Hz. Peygamber’in babası Abdullah’la ana baba bir kardeş olması bakımından onun öz halası olmaktadır. Âtike, hayatında Ebû Ümeyye b. Muğire el-Mahzumî dışında kimse ile evlenmemiş ve bu evlilikten Abdullah b. Ebî Ümeyye, Züheyr b. Ebî Ümeyye ve Kureybe bint Ebî Ümeyye adında üç çocuk dünyaya getirmiştir. Âtike, Bedir savaşından önce içeriği çok detaylı olan bir rüya görmüş ve bunu kardeşi Abbas’a anlatmıştır. O bununla İslam Tarihi’nde üne kavuşmuş ve Mekkelilerin de güvenini kazanmıştır. Onun Mekke’de İslamiyet’i kabul ettiği ve sonrasında da Medine’ye hicret ettiği yönünde gerçeği tartışmalı olan bilgiler bulunmaktadır.
Bu çalışmada eldeki kaynaklar çerçevesinde Hz. Peygamber’in halası Âtike’nin hayatı ele alınacaktır. Spesifik olarak onun hayatı ile ilgili detaylı akademik çalışmalar pek bulunmamaktadır. Bu nedenle onunla ilgili yapılacak olan çalışmalara katkı sunmayı amaçladık.