bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges in the pre- and post-natal diagnosis of posterior fossa cysts: A case report and review of historical evolution of descriptive terminologies
Authors: Kutty Sarvesh , Clarke Glen , Kutty Jayasree 
Published: September 2022

Background:
Radiological diagnoses of posterior fossa cystic abnormalities during antenatal and postnatal periods pose significant challenges as they may have similar early imaging features. Some of the frequently described entities are arachnoid cysts and Dandy-Walker malformations. Blake’s pouch cyst is relatively underdiagnosed. The main aim of the study was to explore these diagnostic challenges in the context of various descriptive terminologies and their prognostic implications.

Methods:
We illustrate this through our case, where fetal magnetic resonance imaging (MRI) at 36 weeks gestation showed small right cerebellum without hydrocephalus or hemorrhage. Possible differential diagnoses included Dandy-Walker malformation or posterior fossa malformations, facial hemangiomas, arterial anomalies, cardiac and eye anomalies, sternal clefting, and supraumbilical raphe.

Results:
Postnatal sonography noted posterior fossa cyst without hydrocephalus in a normal term infant, who went on to develop symptomatic hydrocephalus by 15 weeks. Computed tomography brain scan confirmed large subtentorial posterior fossa cyst and extensive internal hydrocephalus. Despite emergent ventriculoperitoneal shunt insertion, head circumference continued to rise. MRI scan showed persistent cyst. Subsequently, infant underwent endoscopic fenestration of the cyst with balloon septostomy and now has an age appropriate developmental profile.

Conclusion:
There is considerable discordance between antenatal and postnatal neuroimaging findings as highlighted in our case. Diagnostic conundrum here was whether this was an arachnoid or Blake’s pouch cyst. Differentiating between posterior fossa fluid collections is crucial for management, prognosis, and parental counseling. Close postnatal follow-up is essential to avert complications due to acute hydrocephalus.
Spinal intradural solitary fibrous tumor/ hemangiopericytoma with intramedullary invasion mimicking a hemangioblastoma
Authors: Thapa Shanta , Yamahata Hitoshi , Okada Tomohisa , Yonenaga Masanori , Bajagain Madan , Makino Ryutaro , Hanaya Ryosuke 
Published: September 2022

Background:
Solitary fibrous tumor/hemangiopericytomas (SFT/HPCs) are rare mesenchymal tumors of nonmeningothelial origin that comprises <1% of all central nervous system tumors.

Case Description:
A 45-year-old male presented with sleep apnea (apnea-hypopnea index was 17.1 events/hour) and dysesthesias of the right upper and lower extremities. The magnetic resonance demonstrated a heterogeneous intradural extra-axial C1 mass with syringobulbia and syringomyelia. The right vertebral angiography revealed a hypervascular mass (i.e., intense tumor staining). With the preoperative diagnosis of a spinal hemangioblastoma, the patient underwent tumor removal. However, intraoperative findings demonstrated that the ventral component of the tumor was intramedullary without a dural attachment. Further, the histological diagnosis was consistent with SFT/HPC (HPC phenotype). The postoperative course was uneventful, and the patient’s symptoms and the syrinxes spontaneously regressed.

Conclusion:
A 45-year-old male presented a rare spinal intradural lesion at C1 appeared to be a spinal hemangioblastoma, but proved to be SFT/HPC (HPC phenotype) with intramedullary invasion.
Primary intracranial synovial sarcoma: A case report and review of literature
Authors: Vora Tarang K. , Lath Rahul , Swain Meenakshi , Ray Amitava 
Published: September 2022

Background:
Primary intracranial synovial sarcomas (PrISS) are unusual dural based mesenchymal tumors seen most commonly in the supratentorial compartment. They can mimic a spontaneous intracranial hemorrhage or a high-grade glioma on imaging.

Case Description:
A 31-year-old male presented with headache and right hemiparesis for 2 weeks. CT brain revealed a left frontal spontaneous intracerebral hemorrhage. PrISS revealed a heterogeneously ring enhancing solid cystic lesion with attachment to convexity dura. Intraoperatively, it mimicked a high-grade glioma. Histopathology report showed features of a synovial sarcoma, which was later confirmed with IHC. Classical SYT-SSX2 translocation was confirmed only on RTPCR after fluorescent in situ hybridization (FISH) was negative for same. Whole body positron emission tomography (PET-CT) did not show any extracranial tumor. Despite radiotherapy, there were recurrence and tumor progression at 6 months and the patient succumbed 11 months later.

Conclusion:
PrISS is an unusual aggressive intracranial neoplasm that carries a worse prognosis when compared nonintracranial synovial sarcomas. Molecular cytogenetics (FISH and RTPCR) are essential for confirming the diagnosis, though FISH seems to have a lower sensitivity and can yield false negative results as was noted in this case.
Dorsal vertebral body tumor and non-compressive quadriparesis – A rare case report of a phosphaturic mesenchymal tumor
Authors: Bhatjiwale Mrudul Mohinish , Chandrachari Komal Prasad , Kannan Subramanian 
Published: September 2022

Background:
Phosphaturic mesenchymal tumors cause renal phosphate wasting leading to hypophosphatemia manifesting as bone pain and fractures. About 95% of these tumors involve the extremities and the appendicular skeleton, with spinal tumors being exceedingly rare. We describe a case of non-compressive quadriparesis, caused by a thoracic vertebral body phosphaturic mesenchymal tumor (PMT).

Case Description:
A 34-year-old gentleman presented with a 3-year history of gradually progressive quadriparesis, predominantly involving proximal muscles. Magnetic resonance imaging neither showed evidence of compressive lesions nor myelopathy. On routine biochemistry, he was found to have hypophosphatemia and phosphaturia, with serum phosphorus levels of 1.84 mg/dl, and fractional excretion of phosphorus >5%. A DOTATOC positron emission tomography scan suggested the possibility of a PMT in the D10 vertebral body with a corresponding hyperdense/sclerotic focus on non-contrast computed tomography. After instituting phosphate replacement therapy and complete surgical excision of the hyperdense focus, he made a full neurological recovery. His phosphate levels normalized without the need for supplements. Histopathological examination showed spindle cells with positive staining for Vimentin, a mesenchymal cell marker. At 5 years of follow-up, the patient continues to be asymptomatic with a full return to normal function and no residual weakness.

Conclusion:
PMTs involving the spine are a rare reversible cause of non-compressive quadriparesis. Early diagnosis and excision of the lesion correct the hypophosphatemia and result in complete neurological recovery.
Burr hole on polyetheretherketone cranioplasty for the management of chronic subdural hematoma: A case report
Authors: Marrone Salvatore , Costanzo Roberta , Scalia Gianluca , Iacopino Domenico Gerardo , Nicoletti Giovanni Federico , Umana Giuseppe Emmanuele 
Published: September 2022

Background:
In rare cases, chronic subdural hematoma can be a complication following cranioplasty implantation. Therefore, it can develop spontaneously or after a trauma in the underlying site of a duroplasty and represent, if compression of the brain structures, a life-threatening condition. In case of a patient with cranioplasty in polyetheretherketone (PEEK), performing a burr hole on prosthesis can represent, although unusual, an effective and safe technique for evacuation of the chronic subdural hematoma, avoiding the need to remove the prosthesis itself. Nevertheless, a rare and insidious prosthesis infection can occur, even after years.

Case Description:
A 54-year-old male patient, following severe traumatic brain injury, underwent a right hemispheric decompressive craniectomy associated to acute subdural hematoma evacuation and, subsequently, a PEEK cranioplasty implant with polytetrafluoroethylene (PTFE or Gore-Tex) duroplasty. About 10 years later, he experienced worsening headache with sensory alterations; therefore, he underwent a brain computed tomography scan documenting a right hemispheric chronic subdural hematoma (cSDH), expanding in subsequent radiological examinations. Because of symptoms’ worsening, he underwent cSDH evacuation through a burr hole centered on the parietal region of the PEEK prosthesis, associated with mini-reopening of duroplasty. Two years after the procedure, he went to the emergency department because of the appearance of a serum-purulent material drained from the surgical site. He underwent cranioplasty removal and then started a targeted therapy to treat a triple surgical site infection, often unpredictable and totally accidental.

Conclusion:
Based on the literature evidence, performing a burr hole on a cranial prosthesis in bone-like material such as PEEK represents a surgical procedure never performed before and in our opinion could, in selected cases, guarantee the cSDH evacuation and the treatment of intracranial hypertension, avoiding the cranioplasty removal, although there is a risk of even late surgical site infection.
Change of angiogenesis in the nodular form of benign mammary dysplasia during treatment with alkaloids, flavonoids and glycosides
Authors: Pokul' Liliana V. , Chugunova Nina A. , Lebedeva Marina G. , Sorokivskii Ivan M. , Uriupina Anna P. , Solov'eva Elena A. , Utkina Anna M. 
Published: September 2022

Introduction. The formation of new blood vessels is called angiogenesis. As the tumor grows, the oxygen and nutrient requirements of the abnormal cells continuously increase, and new blood vessels are formed. These processes are disrupted by angiogenesis inhibitors. Therefore, it is warranted to investigate ways to enhance the capabilities of angiogenesis inhibitors alkaloids, flavonoids, and glycosides.
Aim. To justify the extension of clinical use of alkaloids, flavonoids and glycosides (Conium maculatum and Hydrastis canadensis, Thuja occidentalis), being a part of the complex medical product Mastopol, taking into account the obtained data on the angiogenic balance in the nodular form of benign mammary dysplasia (BMD).
Materials and methods. The study included 69 volunteers divided into two groups: Group 1 included 27 patients with medical history of surgery for nodular BMD who received antiproliferative preoperative therapy with Mastopol for 12 weeks. Group 2 (comparison group), n=42, also included patients with medical history of surgery for nodular BMD but without preoperative therapy with the herbal medicine Mastopol. We studied angiogenesis markers (VEGF-A [vascular endothelial growth factor] and pVEGF-1) and immunohistochemical marker CD34 (cluster of differentiation CD).
Results. We found a significantly higher (p0.001) rate of CD34 detection on medium and small caliber vessels in the comparison group, i.e., in the patients who were not treated preoperatively with alkaloids, flavonoids, and glycosides (Mastopol), while blood supply to the nodules by the medium and small vessels was 1.4 and 1.8 times lower in the Group 1, respectively. Analysis of VEGF expression shows an increase of angiogenic promoters VEGF-A and pVEGF-1 in serum before treatment with biologically active herbal components of Mastopol in both groups. There were no statistically significant differences in vascular markers. However, a statistically significant decrease in VEGF-A and pVEGF-1 (p0.001) was noted in Group 1 after Mastopol therapy. Note the presence of a moderate direct correlation (rs=0.49) of CD34 expression with VEGF-A expression in Group 1 and rs=0.41 in Group 2, which indicated a direct relationship between angiogenesis and proangiogenic factors.
Conclusion. In addition to the proven antiproliferative, anti-inflammatory, cytokine stabilizing, analgesic, and anti-edema properties of Mastopol, the study also showed the antiangiogenic effect of the herbal drug components. Considering the decreased vascular growth in fibroadenomas during Mastopol treatment, the indications for its use in patients with fibroadenomas before the surgery can be extended. Specific immunological test to measure VEGF can be proposed as a noninvasive screening method to evaluate the effectiveness of conservative treatment in general clinical practice.
KEANEKARAGAMAN JENIS PLANKTON DI PERAIRAN BATU BELUBANG DAN PULAU PANJANG KABUPATEN BANGKA TENGAH SEBAGAI INDIKATOR KUALITAS PERAIRAN
Authors: Novrilianty Herlena , Hudatwi Mu’alimah , Utami Eva 
Published: September 2022

Plankton adalah organisme mikroskopis yang memiliki peranan yang sangat penting yaitu sebagai dasar dari kehidupan, khususnya dalam kehidupan perairan pelagis. Plankton digolongkan menjadi dua jenis yaitu : fitoplankton dan zooplankton. Penelitian ini bertujuan untuk mengetahui jenis plankton, mengidentifikasi hubungan keanekaragaman jenis plankton dengan parameter fisika dengan analisis statistik, dan mengidentifikasi indeks keanekaragaman jenis plankton di Perairan Pantai Batu Belubang dan Pulau Panjang. Waktu dan tempat penelitian ini dilaksanakan pada bulan Bulan Maret 2021 di Perairan Pantai Batu Belubang dan Pulau Panjang Kecamatan Pangkalan Baru Kabupaten Bangka Tengah. Pengambilan data dalam Penelitian ini menggunakan metode random sampling dimana berdasarkan hasil survei yang telah dilakukan. Hasil penelitian menunjukkan bahwa di perairan Pantai Batu Belubang dan Pulau Panjang ditemukan 30 spesies plankton yang terdiri dari 13 family dan total berjumlah 286 spesies dengan indeks keanekaragaman tergolong sedang, indeks keseragaman tergolong tinggi dan untuk indeks dominansi tergolong rendah. Hasil korelasi menunjukkan bahwa memiliki hubungan korelasi yang berbeda-beda nilai dan arahnya.
PERILAKU JOINT BALOK-KOLOM BETON FIBER BENDRAT
Authors: Ngudiyono Ngudiyono 
Published: September 2022

Joint balok-kolom merupakan bagian yang penting dalam bangunan bertingkat dari beton bertulang, dimana daerah ini berfungsi meneruskan gaya-gaya dari balok dan kolom. Oleh karena itu joint balok-kolom harus direncanakan dan dibuat lebih kuat serta berperilaku daktail daripada daerah yang lain. Salah satu cara untuk merubah joint balok-kolom berperilaku daktail dan mudah pelaksanaan di lapangan adalah dengan menambahkan fiber bendrat pada campuran beton. Benda uji telah dibuat untuk mengetahui kapasitas geser dan daktiitas joint balok-kolom. Benda uji dikelompokkan menjadi 4 yaitu joint balok-kolom normal dengan jarak sengkang 50 mm (JBN) dan beton fiber bendrat dengan perbandingan variasi jarak sengkang 50 mm (JBF1), 100 mm (JBF2) dan 150 mm (JBF3). Pembebanan diberikan adalah beban statik, diberikan secara bertahap hingga joint balok-kolom runtuh, besarnya lendutan dicatat dan pola retak yang terjadi diamati. Hasil penelitian menunjukkan bahwa penambahan fiber bendrat sebesar 1% dari volume beton pada joint balok-kolom mampu meningkatkan kapasitas geser joint balok-kolom sebesar 8,67% sampai dengan 10,89% dan daktlitas 34,88% sampai dengan 186,04% serta merubah dan memperlambat pola retak ke arah kolom.
Semântica da Enunciação: um percurso teórico
Authors: Rodrigues Mara Lúcia Martins , Zattar Neuza 
Published: September 2022

Este artigo é o resultado de um dos capítulos desenvolvidos durante o curso no Programa de Pós-Graduação Stricto Sensu em Linguística da Universidade do Estado de Mato Grosso/Unemat e tem como propósito apresentar os estudos sobre enunciação desenvolvidos por Bally (1932), Benveniste (1966; 1974), Ducrot (1972; 1973; 1984), na França, e por Guimarães (1987; 1995; 2002; 2018) e Dias (2018), no Brasil.
Alguns problemas de consciência fonológica ditongal do professor brasileiro de língua inglesa como L2
Authors: Rossa Priscila , Ayres Carlos Renê , Cumpri Marcos Luiz 
Published: September 2022

Este trabalho levanta problemas na consciência fonológica de professores de inglês como L2, que é um dos maiores obstáculos para o ensino eficiente. Como foco de pesquisa, contornamos os aspectos ditongais no nível segmental da pronúncia. O método utilizado é o indutivo e a aplicação consistiu na coleta, via gravação de áudio, da fala de cinco professores de língua inglesa como L2 em universidades e cursos de idioma. Após a análise das pronúncias, por meio de comparação com o General American Accent, pudemos identificar que há uma discrepância considerável em relação ao nível de consciência fonológica de professores brasileiros de língua inglesa.
"O delírio do verbo". Uma reflexão em torno de características teórico-metodológicas da TOPE
Authors: Valentim Helena Topa 
Published: September 2022

Com o objetivo de revisitar algumas características teórico-metodológicas da TOPE, não se opta, neste artigo, por uma reflexão sistematizadora sobre a identidade na variação de uma forma linguística nem pela exploração teórica em torno de um qualquer conceito. Convocar-se-á, antes, para tal, alguns outros objetos, de natureza diversa. Alguns serão linguísticos, problematizações a partir de observáveis. Outros correspondem a textos de autores não linguistas, sobretudo de escritores e de poetas, que comportam intuições aproximáveis, ou mesmo em convergência com características teórico-metodológicas da TOPE. O mesmo se passa com outros objetos, no caso, não linguísticos, por exemplo, imagens ou instalações artísticas, que constituem outras formas de pensamento, não linguístico, e que, segundo propomos, auxiliam na compreensão de conceitos teóricos da TOPE.
Procura-se dar um fio condutor à sequência destes fenómenos, com hipóteses descritivas baseadas no programa de trabalho culioliano, mas – frise-se – sem uma pretensão sistematizadora, mesmo quando cada caso o permitisse perspetivar. Propõe-se, por conseguinte, um levantar de problemas, numa perspetiva problematizadora e fundamentada no programa de trabalho de Culioli.
Brain Protection in Patients with Aortic Dissection and Coronary Artery Disease
Authors: Zhekov Ihor I. , Kravchenko Vitalii I. , Sarhosh Oleh I. , Zinchenko Genadii A. , Rudenko Anatoliy V. 
Published: September 2022

The aim. To compare the effectiveness of methods of protecting the brain and visceral organs during operations for aortic aneurysms combined with coronary artery lesions.
Materials and methods. In the period from 2012 to 2020, 23 patients with Stanford type A and non-A non-B aortic dissection with damage to the coronary arteries were operated at the National Amosov Institute of Cardiovascular Surgery of the NAMS of Ukraine using the brain protection techniques. Out of 23 surgical interventions, 16 were performed for Stanford type A acute aortic dissection, 3 for Stanford type A chronic aortic dissection, 1 for Stanford type A subacute aortic dissection, and 3 for Stanford non-A non-B aortic dissection. The main causes of aortic dissection were hypertension (16 patients), Marfan syndrome (3 patients), bicuspid aortic valve (4 patients).
Results. The most threatening postoperative complication in this group of patients is neurological damage, which was observed in 4 (17%) patients after surgery, with gradual recovery of brain function. Also, the complications observed were respiratory failure in 3 (13%) patients, which required long-term artificial ventilation (more than 72 hours), and multiple organ failure in 1 (4.3%) patient, which caused a fatal outcome.Complications such as kidney and liver failure were not observed (most likely due to the small sample size). Heart failure was not noted as well. Hospital mortality was 4.3% (1 fatal case). In our study, among the entire group of operated patients, symptoms of neurological damage occurred in 4 (17.4%) patients, hemorrhagic stroke was present in 1 (4.3%) patient with a complicated medical history, 2 (8.6%) patients had hemiparesis and in 1 case (4.3%) there were cognitive disorders.
Conclusions. Comparing brain protection techniques, taking into account the prolongation of aortic clamping time due to coronary artery shunting compared to isolated aortic dissection, it can be concluded that longer duration of selective brain perfusion (retrograde or antegrade) or duration of circulatory arrest more often lead to postoperative complications, namely neurological lesions.
On the other hand, the small number of observations does not make it possible to fully assess the impact of each of the techniques. Further follow-up with a larger sample will provide opportunities for a more complete evaluation of brain protection techniques in operations for dissecting aortic aneurysms and coronary artery lesions.
Covid-19: A Retrospective Study About The Challenges for ERCP?
Authors: CAKCAK İbrahim Ethem , KAYABAŞ Merve Yaren , CANSIZ Sıla , YILMAZ Mustafa Numan , ALBAYRAK Doğan 
Published: September 2022

NTRODUCTION: We aimed to investigate the effects of Covid-19 on Endoscopic retrograde cholangiopancreatography (ERCP) and to investigate what should be considered in the next possible epidemic situations.
METHODS: In our study, patients who applied to XXX University School of Medicine, Department of General Surgery for ERCP (Endoscopic retrograde cholangiopancreatography) between March 2019 and March 2021 were evaluated, retrospectively. Percentages, mean, standard deviation, median and interquartile range were used as the descriptive statistics. Mann-Whitney U test was used for the variations which are contrary to the normal distribution range in the comparison of two groups. The relations between qualitative variations were studied by the Pearson Chi-Square test and Fisher's Exact test. Significant value was determined as 0.05 for all statistical analyses.
RESULTS: Prior to COVID-19, ERCP indications were in the order of stone (90.1%), stent removal (8%) and tumor (1.1%), while in the period of COVID-19, the ranking changed to stone (73.8%), tumor (13.7%), and stent removal (12.4%).. The diagnostic use of ERCP has been greatly reduced (from 0.7% to 0.0%). No perforation was detected in both periods, there was no bleeding, but a small increase (4.7% to 5.9%) was found in pancreatitis in the COVID-19 period. In the pre-COVID-19 period, stones were detected in 46.2% of the patients and all of them were successfully removed, but during the COVID-19 period, stones were detected in 50.6% of the patients and the stones could not be removed in 1.3% of the patients.
DISCUSSION AND CONCLUSION: It was observed that the number of ERCPs decreased due to the delay in admissions to the hospital and the fear of coming to the hospital during the Covid-19 epidemic period, and the number of malignancies diagnosed with ERCP increased in this process. In such epidemic periods, more scheduled health services will provide better results for both patients and health personnel.
Impact of Glutathione Administration on Antioxidant Levels and Ileum Histologic of Growth Phase of Cihateup Duck in Extensively Maintained
Authors: Mushawwir Andi , Suwarno N. , Aritonang H.N. 
Published: September 2022

This research has been carried out for a month using eighty three-month-old female Cihateup ducks and has been used to study the influence of glutathione on the endogen antioxidant response and histological illeum. The separation of glutathione was carried out using the distillation technique. Each experimental group consisted of 20 ducks, each treated with G0 = without glutathione; G1= Administration of glutathione 150 µL/head; G2 = Administration of glutathione 175 µL/head; G3= Administration of glutathione 175 µL/head. Tissue and blood sampling was collected at the end of the study by EDTA tube and a fixative solution, and tissue preparations were made using the Mallory-Asan technique and analyzed using a binocular microscope. Antioxidant levels were measured using a spectrophotometer technique based on the instructions of the Randox Kit. The results showed that glutathione affected (P<0.05) morphometric ileum (villi, Peyeri's plaque and goblet cells) and increased with increasing glutathione level and endogenous antioxidant response. It was concluded that glutathione is able to stimulate protein and lipid anabolism, as well as hormonal signals related to ileal tissue growth and antioxidants.