bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thromboelastometry (ROTEM) Assessing Hypercoagulability in Patients Referred for Thrombophilia Screening
Authors: Assar Mazen , Nilius Henning , Kearn Natalie , Hopman Wilma , Nagler Michael , Othman Maha 
Published: February 2025

ABSTRACTIntroductionThrombophilia, a blood coagulation disorder, poses risks of venous thromboembolism (VTE). Coagulation assays may not be sufficient to assess VTE risk and global assays such as Rotational Thromboelastometry (ROTEM) may add valuable information. We investigated ROTEM's capacity to detect hypercoagulability in patients undergoing thrombophilia screening, its potential impact on patient outcomes, and limitations.MethodsComprehensive clinical, laboratory, genetic tests, and ROTEM (EXTEM and INTEM) were conducted for 356 patients referred for thrombophilia screening at an academic hospital outpatient unit. Hypercoagulability was identified as a shorter clot formation time (CFT), larger alpha angle (AA), and greater maximum clot firmness (MCF), and was compared in patients with and without VTE. Statistically this was analyzed using Mann–Whitney U and Chi‐square tests with p < 0.05 considered significant.ResultsAmong 356 patients, 64.6% had previous VTE, with 76.9% experiencing one event, 14.3% recurrent (35.6% unprovoked, 64.4% provoked). 22.5% of patients were on anticoagulation. Those with VTE history exhibited significant alterations in EXTEM and INTEM parameters compared to those without (p < 0.001), showing decreased CFT and increased AA and MCF. However, receiver operating characteristic curves for these variables indicated that none were able to discriminate between those individuals with and without thromboembolic complications.ConclusionROTEM does not appear to be a strong discriminatory test. However, it can detect hypercoagulopathy in patients referred for thrombophilia screening. Abnormal ROTEM may indicate a higher risk for recurrence. However, this can only be determined in prospective cohort studies.
Recruitment Practices in Times of Demographic Change: The Case of Japan
Authors: Hennings Matthias , Pilz Matthias , Bebenroth Ralf 
Published: February 2025

ABSTRACTDue to a shrinking number of employable graduates, companies in industrialised nations have increasingly faced problems in hiring qualified young people. This situation is particularly pronounced in Japan, where companies are competing for the best talents. Based on a multi‐stakeholder perspective, this study examines changes in the Japanese recruitment system from the viewpoint of companies, university career centres and external organisations involved in recruitment. Using in‐depth interviews with these stakeholders, this study investigates how recruitment practices in Japan have changed, which guidelines for recruitment are currently followed by companies, and to what extent traditional recruitment practices still prevail. As the results show, recruiting activities in Japan have accelerated over the last years with companies trying to recruit university students early in their studies to secure qualified talents. This article also discusses the implications of these findings for Japan and other industrialised countries with similar demographic problems.
Contract strategy in a nonexclusive system under the competition
Authors: Li Xiaojing , Gu Feng , Ai Xingzheng 
Published: February 2025

AbstractThis paper studies the contract strategy of the nonexclusive supply chain, where two manufacturers supply competing products to two retailers nonexclusively. The retailers can choose a revenue‐sharing contract or a wholesale price contract to trade with the manufacturers. We compare and analyze the different contract arrangements and provide insights into the impact of the nonexclusive selling format, the product competition, and the retailer competition on the contract decision. Our results show that in the presence of nonexclusive selling, competition between retailers is an important factor in the contract choice. Existing literature has shown that the wholesale price contract enables participants to achieve Pareto improvement when the market competition is fierce. In contrast, we find that the intense retailer competition has resulted in neither the revenue‐sharing nor wholesale price contracts dominating. In this case, the negotiations between the manufacturer and the retailer on the revenue‐sharing ratio could not be successful, so they are forced to deal with a wholesale price contract. The wholesale price contracts could achieve a win‐win situation only when the retailer competition is weak and the product competition is fierce. Furthermore, in the case of exclusive selling, the revenue‐sharing contract can only be an equilibrium strategy for manufacturers and retailers, regardless of the fierce or weak competition of retailers.
Structural stability of the robust GdYTi2O7 pyrochlore under high pressure
Authors: Singh Yogendar , Kumar Vivek , Vazhappilly Tijo , Poswal Himanshu Kumar , Pandey K. K. , Kulriya Pawan Kumar 
Published: February 2025

AbstractComplex ceramics with pyrochlore (A2B2O7) and defect‐fluorite ((A, B)4O7) type structures experience structural modifications under high pressure. Here, we used mechanical milling and sintering followed by compression in diamond anvil cell to determine the high‐pressure behavior using in‐situ synchrotron diffraction. Raman spectroscopy and X‐ray diffraction at ambient pressure confirm the pyrochlore phase of as‐prepared GdYTi2O7 ceramic. In‐situ high‐pressure experiments reveal no structural phase transition in GdYTi2O7 pyrochlore up to approximately 50 GPa. The variation in the x positional coordinate of O48f oxygen and cation–anion bond lengths shows that disordering occurs at high pressure above ∼43 GPa. The Rietveld refinement results indicate the pyrochlore phase of GdYTi2O7 ceramic at the highest pressure of ∼50 GPa. Compared to Y2Ti2O7, the equal substitution of Y3+ and Gd3+ at the A‐site increases phase stability at high pressures. The experimental results indicate that mainly cation disordering occurs with increasing pressure, and lower compressibility of < Ti–O48f > bonds should play a significant role in the robustness of GdYTi2O7 pyrochlore to sustain pyrochlore structure up to very high pressures. DFT‐derived cation–anion bond lengths and bulk modulus value agree with the experimental results in supporting the robustness of the GdYTi2O7 pyrochlore.
Morphological and Molecular Phylogenetic Characterization of Three New Marine Goniomonad Species
Authors: Phanprasert Yasinee , Kim Sun Young , Kang Nam Seon , Jeong Minseok , Kim Jong Im , Shin Woongghi , Lee Won Je , Kim Eunsoo 
Published: February 2025

ABSTRACTGoniomonads are commonly found heterotrophic biflagellates in both marine and freshwater environments. Despite the high genetic diversity inferred from 18S rDNA data, many goniomonad species remain undescribed. In this study, we established a total of 21 marine goniomonad culture strains, and from these, describe three new species by using 18S rDNA phylogeny, light microscopy, and electron microscopy. Molecular sequence analyses suggest the presence of several distinct sub‐lineages within the marine goniomonad clade. Two of these are Goniomonas ulleungensis sp. nov. and G. lingua sp. nov., which are similar in size, flagellar length, appendage, and orientation and have a tongue‐like protrusion at the anterior. The two species can be differentiated by the periplast plate pattern with G. ulleungensis displaying one additional plate on the right side. G. duplex sp. nov. differed from these two species by having two unequal flagella with the longer one trailing posteriorly and having the opposite cell orientation when skidding. Comparative analyses of five marine goniomonad species showed that genetically distinct goniomonad groups can be delineated by morphological data as well, and of several morphological features that are of taxonomic utility, the periplast plate pattern, observable by SEM, is particularly informative in goniomonad taxonomy.
Study on the Correlation Between Water Content of Peanut Kernel, Water Phase State and Electrical Impedance Spectrum Parameters
Authors: Dong Zhanwei , Feng Longlong , Liu Zhixia , Zhao Jun , Wang Jing , Zhang Meiyue 
Published: February 2025

ABSTRACTIn an effort to develop a novel approach for detecting the moisture content of peanut kernels and enhancing detection efficiency, this study employed electrical impedance technology, and low‐field nuclear magnetic resonance technology to investigate the relationship between water phase state, impedance values (real and imaginary components), phase angle, and moisture content of peanut kernels ranging from 10.4% to 41.0%. The findings revealed that water in the peanut kernel mainly gathered in the middle part of the two cotyledons. As the moisture content escalates from 10.4% to 41.0%, the ratio of free water to bound water decreased from 6.3:1 to 1.9:1. The highest correlation coefficient was observed between the real part of impedance and moisture content, whereas the phase angle exhibited the lowest correlation coefficient. The real part of impedance emerged as the most effective impedance spectrum parameter for modeling the moisture content of peanut kernels. Furthermore, the relationship between electrical impedance spectrum parameters, and water content was found to be frequency‐dependent, with the highest correlation between the real part of impedance and water content observed in the frequency range of 1–4 MHz, yielding an R2 value of 0.986. These research outcomes offer valuable insights for advancing the development of rapid and nondestructive moisture content detection technologies for peanut kernels utilizing resistance methods.
Somatic variations in the meiosis‐specific gene CrMER3 confer seedlessness in a citrus bud sport
Authors: Fan Yan‐Jie , Du Ze‐Zhen , He Xing‐Yi , Liu Zi‐Ang , Zhuang Ji‐Xin , Xiao Gong‐Ao , Duan Yao‐Yuan , Tan Feng‐Quan , Xie Kai‐Dong , Jiao Wen‐Biao , Zhang Fei , Yang Chao , Guo Wen‐Wu , Wu Xiao‐Meng 
Published: February 2025

ABSTRACTSeedlessness is a most valuable trait in fruit crops for fresh consumption and processing. The mutations in essential meiosis genes are known to confer sterility and seed abortion in plants. However, defects in meiosis have rarely been reported in fruit crops. Here, we found meiosis defects caused sterility in a seedless citrus bud sport cultivar, with massive unpaired univalents during diakinesis, indicating a disruption in crossover formation. A non‐functional CrMER3A‐103 bp allele with a 103‐bp deletion in the gene body, together with the other non‐functional CrMER3a allele with a T deletion in exon, were identified in the seedless cultivar. The CrMER3 protein was undetectable at meiotic prophase I in the seedless cultivar, and knock out of CrMER3 resulted in sterility in precocious Mini‐citrus. Therefore, the natural variation in CrMER3 is responsible for sterility and seedlessness in this bud sport cultivar. The CrMER3a allele originated from the primitive wild mandarin and was passed to cultivated mandarins. A Kompetitive Allele‐Specific PCR (KASP) marker was developed to identify citrus germplasm with CrMER3a allele and to screen potential sterile and seedless hybrids in citrus cross breeding. Uncovering the natural mutations responsible for meiosis defects in citrus enhances our understanding of mechanisms controlling seedlessness in fruit crops and facilitates breeding of seedless varieties.
Comparing the impact of three‐dimensional display systems and barbed V‐LOC™ sutures in laparoscopic hysterectomy: A retrospective cohort study
Authors: Tercan Can , Dagdeviren Emrah , Yeniocak Ali Selcuk , Can Sultan , Aktoz Fatih 
Published: February 2025

AbstractAimThis study aims to evaluate the impact of two‐dimensional (2D) versus three‐dimensional (3D) imaging systems and barbed versus standard absorbable multifilament sutures on surgical times and complications in total laparoscopic hysterectomy.MethodsA retrospective cohort study was conducted at a tertiary hospital between May 2020 and September 2024. Patients who underwent total laparoscopic hysterectomy were categorized into four groups based on imaging system (UltraHD‐2D vs. FullHD‐3D) and suture type (VICRYL™ multifilament suture interrupted figure‐of‐8 technique vs. V‐LOC™ barbed suture running technique). Primary outcomes included vaginal cuff closure time and total operation duration. Secondary outcomes were mean suturing time, perceived difficulty, and postoperative complications.ResultsA total of 159 patients were analyzed. Vaginal cuff closure time was significantly shorter with 3D imaging systems compared to 2D systems when VICRYL™ sutures were used (13.85 ± 4.30 vs. 21.17 ± 5.13 min, p < 0.001). No significant difference was observed between imaging systems when V‐LOC™ barbed sutures were used. Across both systems, V‐LOC™ sutures consistently reduced suturing time compared to VICRYL™ sutures (p < 0.001). Surgeon‐perceived difficulty was lower with V‐LOC™ sutures, particularly in 2D systems. No significant difference in complication rates was observed between groups (p = 0.188).ConclusionThe use of 3D imaging systems in total laparoscopic hysterectomy significantly reduces vaginal cuff closure duration and overall operative time with VICRYL™ sutures, while V‐LOC™ sutures consistently enable faster procedures across both imaging modalities. These findings suggest that 3D imaging systems and barbed sutures may enhance surgical efficiency without increasing complication rates.
Actigraphy against 32‐hour polysomnography in patients with suspected idiopathic hypersomnia
Authors: Adam Tugdual , Tanty Jérôme , Barateau Lucie , Dauvilliers Yves 
Published: February 2025

SummaryActigraphy, a tool known for investigating sleep–wake patterns at home, lacks scientific validation in hypersomnolent subjects. We aim to validate an actigraphy‐based sleep–wake prediction algorithm against 32‐h continuous polysomnography in patients with suspected idiopathic hypersomnia, and to compare its performance to predict sleep–wake parameters assessed by polysomnography with those of a commercially available algorithm. Two hundred and six hypersomnolent subjects were included prospectively in a Reference Centre for Hypersomnias, and underwent a 32‐h bedrest protocol, wearing wrist‐actigraphy, to diagnose idiopathic hypersomnia. Among them, 126 patients (91 females, 30.6 ± 15.5 years, 101 idiopathic hypersomnia, 25 non‐specified hypersomnia) with synchronised actigraphy and polysomnography were analysed. Age, sex, and Epworth Sleepiness Scale scores were collected. We trained various supervised algorithms and selected a recurrent neural network (S2S sequence‐to‐sequence long short‐term memory network) for comparison with Actiwatch Software (AS) on sleep–wake variables and prediction errors during daytime and nighttime. S2S outperformed AS across all relevant metrics, and Bland–Altman analysis showed disagreement between the two algorithms. S2S had a lower absolute error than AS. AS mainly overestimated sleep, an overestimation that was substantially reduced with S2S, overall as well as during day and night. Performance was not correlated with age, sex, or subjective sleepiness, but objective sleepiness and longer sleep time on the bedrest were associated with sleep underestimation. Our S2S algorithm using deep learning performed better to predict sleep–wake parameters than AS and other commonly used algorithms. The next objective is to leverage this algorithm to study sleep–wake patterns in patients with hypersomnolence at home.
The crime of counterfeiting or imitating a trademark under Jordanian trademarks law
Authors: Juwaihan Ma'en , Abu Issa Hamzeh , Khater Mohammad Nasr 
Published: February 2025

AbstractThis paper critically analyzes the crime of counterfeiting or imitating trademarks under Article 37/1/a of the Jordanian Trademarks Law No. 33 of 1952 and its amendments. Recognizing a significant gap in the alignment of Jordanian trademark laws with international standards, the study aims to evaluate the effectiveness of current legislation in protecting trademark owners' rights and consumer interests. The importance of this research lies in the escalating instances of trademark infringement, which undermine consumer trust, hinder economic growth, and affect Jordan's compliance with international treaties. Employing descriptive, analytical, and comparative methodologies, the paper examines the material, moral, and subjective elements of the crime, explores jurisprudential and judicial debates on criminal intent, and compares Jordanian legal provisions with those of other jurisdictions. The study shows that, while Jordanian law prohibits the counterfeit of marks, it does not specifically protect well‐known marks, and it is inconsistent in the presumption of intention to commit a crime. Moreover, the sentence for attempted trademark infringement does not align with the general principles of Jordanian criminal law. The study recommends that the Jordanian system should consider legislative improvements to ensure stronger protection for trademarks in Jordan. It will also advise to amend Article 37 to set provision for well‐known trademarks and more delimitative provisions on criminal intent to conform to the dowry of presumption of innocence, enhance deterrent in penalties, and to be in line with penalty slow down to the international law practice. This paper seeks to address these gaps, contribute to the debate about the purpose of intellectual property rights, and provide suggestions for policymakers who are looking towards enhancing legislative protection from trademark infringement to promote increased economic stability and consumer safety.
Artificial Intelligence: An Emerging Tool for Studying Drug‐Induced Liver Injury
Authors: Niu Hao , Alvarez‐Alvarez Ismael , Chen Minjun 
Published: February 2025

ABSTRACTDrug‐induced liver injury (DILI) is a complex and potentially severe adverse reaction to drugs, herbal products or dietary supplements. DILI can mimic other liver diseases clinical presentation, and currently lacks specific diagnostic biomarkers, which hinders its diagnosis. In some cases, DILI may progress to acute liver failure. Given its public health risk, novel methodologies to enhance the understanding of DILI are crucial. Recently, the increasing availability of larger datasets has highlighted artificial intelligence (AI) as a powerful tool to construct complex models. In this review, we summarise the evidence about the use of AI in DILI research, explaining fundamental AI concepts and its subfields. We present findings from AI‐based approaches in DILI investigations for risk stratification, prognostic evaluation and causality assessment and discuss the adoption of natural language processing (NLP) and large language models (LLM) in the clinical setting. Finally, we explore future perspectives and challenges in utilising AI for DILI research.
Multi‐hazard probabilistic risk assessment and equitable multi‐objective optimization of building retrofit strategies in hurricane‐vulnerable communities
Authors: Braik Abdullah M. , Gupta Himadri Sen , Koliou Maria , González Andrés D. 
Published: February 2025

AbstractCoastal communities are increasingly vulnerable to hurricanes, which cause billions of dollars in damage annually through wind, storm surge, and flooding. Mitigation efforts are essential to reduce these impacts but face significant challenges, including uncertainties in hazard prediction, damage estimation, and recovery costs. Resource constraints and the disproportionate burden borne by socioeconomically vulnerable groups further complicate retrofitting strategies. This study presents a probabilistic methodology to assess and mitigate hurricane risks by integrating hazard analysis, building fragility, and economic loss assessment. The methodology prioritizes retrofitting strategies using a risk‐informed, equity‐focused approach. Multi‐objective optimization balances cost‐effectiveness and risk reduction while promoting fair resource allocation among socioeconomic groups. The novelty of this study lies in its direct integration of equity as an objective in resource allocation through multi‐objective optimization, its comprehensive consideration of multi‐hazard risks, its inclusion of both direct and indirect losses in cost assessments, and its use of probabilistic hazard analysis to incorporate varying time horizons. A case study of the Galveston testbed demonstrates the methodology's potential to minimize damage and foster equitable resilience. Analysis of budget scenarios and trade‐offs between cost and equity underscores the importance of comprehensive loss assessments and equity considerations in mitigation and resilience planning. Key findings highlight the varied effectiveness of retrofitting strategies across different budgets and time horizons, the necessity of addressing both direct and indirect losses, and the importance of multi‐hazard considerations for accurate risk assessments. Multi‐objective optimization underscores that equitable solutions are achievable even under constrained budgets. Beyond a certain point, achieving equity does not necessarily increase expected losses, demonstrating that more equitable solutions can be implemented without compromising overall cost‐effectiveness.
No Association of Pediatric Vitiligo With Visual Acuity Deficits
Authors: Tissera Kristin A. , Buros‐Stein Amy , Delva Camile A. , Mayur Omkar , Hawryluk Elena B. , Harris John , Garza‐Mayers Anna Cristina 
Published: February 2025

ABSTRACTVitiligo is characterized by the autoimmune destruction of melanocytes, which most visibly affect skin pigmentation, but are also present in the choroid and retinal pigmented epithelium of the eye raising the possibility of underappreciated vision loss in affected populations. To inform whether this vulnerable population should be more rigorously screened and offered early intervention, we performed a multi‐center retrospective analysis of optotype recognition of 248 pediatric vitiligo patients compared with 496 age‐ and sex‐matched healthy subjects between 2000 and 2023; we found a significant difference in the risk of visual acuity deficits in patients as compared with healthy controls (p = 0.0476), although this association was lost when controlling for family history and genetic diagnoses associated with visual acuity deficits or vision loss. These results extend prior studies in adult populations and are consistent with current guidelines that do not recommend routine vision screening the pediatric vitiligo population, although further studies are warranted to determine if there are more subtle changes in vision and eye function.