bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endothelial cell death after ionizing radiation does not impair vascular structure in mouse tumor models
Authors: Kaeppler Jakob R , Chen Jianzhou , Buono Mario , Vermeer Jenny , Kannan Pavitra , Cheng Wei‐Chen , Voukantsis Dimitrios , Thompson James M , Hill Mark A , Allen Danny , Gomes Ana , Kersemans Veerle , Kinchesh Paul , Smart Sean , Buffa Francesca , Nerlov Claus , Muschel Ruth J , Markelc Bostjan 
Published: July 2022

AbstractThe effect of radiation therapy on tumor vasculature has long been a subject of debate. Increased oxygenation and perfusion have been documented during radiation therapy. Conversely, apoptosis of endothelial cells in irradiated tumors has been proposed as a major contributor to tumor control. To examine these contradictions, we use multiphoton microscopy in two murine tumor models: MC38, a highly vascularized, and B16F10, a moderately vascularized model, grown in transgenic mice with tdTomato‐labeled endothelium before and after a single (15 Gy) or fractionated (5 × 3 Gy) dose of radiation. Unexpectedly, even these high doses lead to little structural change of the perfused vasculature. Conversely, non‐perfused vessels and blind ends are substantially impaired after radiation accompanied by apoptosis and reduced proliferation of their endothelium. RNAseq analysis of tumor endothelial cells confirms the modification of gene expression in apoptotic and cell cycle regulation pathways after irradiation. Therefore, we conclude that apoptosis of tumor endothelial cells after radiation does not impair vascular structure.
Sirtuins as potential therapeutic targets for mitigating OxInflammation in typical Rett syndrome: plausible mechanisms and evidence
Authors: Cordone Valeria , Pecorelli Alessandra , Valacchi Giuseppe 
Published: July 2022

Graphical abstract

Abstract
Rett syndrome (RTT), a monogenic neurodevelopmental disorder mainly affecting female, is caused by mutations in X-linked MECP2 gene, an ubiquitous epigenetic regulator. In addition to neurological issues, RTT patients show a variety of multisystem manifestations and impairment of different signalling and metabolic pathways, including compromised mitochondrial function, altered redox homeostasis, improper cholesterol metabolism and subclinical inflammation. The sirtuin family (SIRTs), comprising seven members, catalyses the NAD+-dependent deacetylation, ADP-ribosylation and deacylation of a wide range of targets and works as sensors of cellular energetic status. In addition, SIRTs can modulate activities and gene expression of proteins involved in cellular stress responses related to oxidative stress, mitochondrial dysfunctions and inflammation, in both physiological and pathological conditions. Given some shared molecular aspects, herein, we revised the current scientific literature and hypothesized the possible relationship of SIRTs signalling involvement in RTT pathogenesis and OxInflammation. Although further research is needed, uncovering the possible involvement of SIRTs in RTT could reveal new potential pharmacological targets for the disorder. In light of this, SIRT-enhancing compounds could likely represent a new option to be tested as co-adjuvant alternatives to the current therapies.
Essential trace element selenium and redox regulation: its metabolism, physiological function, and related diseases
Authors: Saito Yoshiro 
Published: July 2022

Graphical abstract

Abstract
The essential trace element selenium plays a significant role in redox homeostasis in the human body. Selenium is very reactive and has a potent toxicity; however, the living body cleverly utilizes its reactivity for redox reactions. The biological function of selenium is mainly mediated by selenoproteins, which contain selenocysteine, a cysteine analogue that possesses selenium instead of sulphur. Twenty-five types of human selenoproteins have been identified, including glutathione peroxidase (GPX; for the reduction of hydrogen peroxide and lipid hydroperoxide) and thioredoxin reductase (for redox regulation). Selenoprotein P (SELENOP), which is a major selenoprotein in the plasma, is mainly synthesized in the liver and secreted into the plasma. As a multifunctional protein with selenium-transporting activity, GPX-like activity, and metal-binding properties, SELENOP plays a vital role in selenium metabolism and redox regulation. This review focuses on the relationship between selenium metabolism and redox regulation, particularly on the physiological role of selenoproteins and the pathophysiological implications of its disorder. Furthermore, the significant roles of selenium in infectious diseases and its utility for phylaxis are discussed.
Covid-19 Case with Mild Pneumonia
Authors: Ikhsan Mukhtar 
Published: July 2022

Background: On December 31, 2019, WHO China Country Office reported a case of pneumonia of unknown etiology in Wuhan City, China. On January 7, 2020, China identified pneumonia of unknown etiology as a grew type of coronavirus (coronavirus disease, COVID-19).Case report: A 39-year-old woman – health care worker - came to the hospital with the chief complaint of coughing three days earlier. Dry cough with no phlegm, fever and no shortness of breath. There are also no other complaints. On physical examination found no abnormalities. There is no history of traveling abroad but there is a history of contact with sufferers of COVID-19 when treating patients. Patients diagnosed as acute respiratory infection were given cefixim 2 x 200 mg for 5 days, paracetamol if necessary and vitamins. Chest X-ray examination is normal while CT X-ray examination without contrast shows a picture of ground glass opacity (GGO). The PCR swab was found to be positive. The patient was diagnosed as positive for COVID-9 with Mild Pneumonia. The patient underwent independent isolation by taking the hydrochloroquin sulfate on day 1: 2 x 2 tab, days 2 - 14: 2 x 1 tab. In addition, the patient also took 1 x 1000 mg of Vitamin C supplements, 1 x 200 IU of vitamin D3 and 1 x 20 mg of Zinc.Results:Clinical symptoms are getting better. On the chest CT scan, the GGO image has improved. The PCR swab turned negative. The patient with COVID-19 with Mild Pneumonia cured.
The Association of Race, Ethnicity, and Poverty With Child Maltreatment Reporting
Authors: Rebbe Rebecca , Sattler Kierra MP , Mienko Joseph A. 
Published: July 2022

OBJECTIVES
To determine the role of race/ethnicity and poverty in the likelihood of children younger than age 3 years hospitalized because of child abuse and neglect-related injuries being reported to child protective services (CPS) and being assigned a specific maltreatment diagnostic code.

METHODS
We used population-based linked administrative data comprising of birth, hospitalization, and CPS records. Children were identified for maltreatment-related hospitalizations using standardized diagnostic codes. Regression models were used to compute crude and adjusted race/ethnicity estimates regarding the likelihood of being reported to CPS and assigned a specific maltreatment diagnostic code during the maltreatment-related hospitalization.

RESULTS
Of the 3907 children hospitalized because of child maltreatment, those with public health insurance were more likely than those with private insurance (relative risk [RR]: 1.29; 95% confidence interval [CI], 1.16-1.42) and those with Asian/Pacific Islander mothers were less likely than those with White mothers to be reported to CPS (RR: 0.78; 95% CI, 0.65-0.93). No differences were found for children with Black, Hispanic, and Native American mothers compared with those with White mothers for CPS reporting. However, children with Native American mothers (RR: 1.45; 95% CI, 1.11-1.90) and public health insurance (RR: 2.00; 95% CI, 1.63-2.45) were more likely to have a specific maltreatment diagnostic code, the second strongest predictor of a CPS report.

CONCLUSIONS
Race/ethnicity and poverty were factors for CPS reports during a child maltreatment-related hospitalization. It is necessary to implement programs and policies that mitigate implicit bias to prevent inequities in which children receive protective intervention.
Fomentando la competencia intercultural en el aula universitaria: trabajando la empatía histórica a través de the thing around your neck, de Chimamanda Ngozi Adichie”
Authors: Perales Fernández de Gamboa Andrea , Apaolaza-Llorente Dorleta , Orcasitas-Vicandi María 
Published: July 2022

La empatía histórica se define como el proceso de compromiso cognitivo y afectivo que los estudiantes adquieren con las figuras históricas para comprender sus experiencias, toma de decisiones y acciones. La empatía histórica implica el entendimiento de cómo las personas, en el pasado, pensaban, sentían, decidían, actuaban y afrontaban las consecuencias dentro de un contexto histórico y social específico. Esta es una herramienta fundamental para el cambio de paradigma en la enseñanza histórica conectando tres procesos: la contextualización histórica, la toma de perspectiva y la conexión afectiva. Así, la propuesta que presentamos tiene dos objetivos: trabajar la empatía histórica desde la literatura, enfoque novedoso y único, y trabajarla en un aula universitaria. Consideramos que, debido a la exclusión que tradicionalmente han sufrido las mujeres, su literatura es la más pertinente para desarrollar esta propuesta. Por ello, utilizaremos el cuento “A Private Experience”, de Chimamanda Ngozi Adichie, incluído en The Thing Around Your Neck.
Implementation and Analysis of Combined Machine Learning Method for Intrusion Detection System
Authors: Masduki Bisyron Wahyudi , Ramli Kalamullah , Murfi Hendri 
Published: July 2022

As one of the security components in Network Security Monitoring System, Intrusion Detection System (IDS) is implemented by many organizations in their networks to detect and address the impact of network attacks. There are many machine-learning methods that have been widely developed and applied in the IDS. Selection of appropriate methods is necessary to improve the detection accuracy in the application of machine-learning in IDS. In this research we proposed an IDS that we developed based on machine learning approach. We use 28 features subset without content features of Knowledge Data Discovery (KDD) dataset to build machine learning model. From our analysis and experiment we get 28 features subset of KDD dataset that are most likely to be applied for the IDS in the real network. The machine learning model based on this 28 features subset obtained 99.9% accuracy for both two-class and multiclass classification. From our experiments using the IDS we have developed show good performance in detecting attacks on real networks.
Jurisdictional and Non-jurisdictional Forms of Patent Rights Protection: Russian and Foreign Experience
Authors: Diakonova Maria O. , Pechegina Polina D. 
Published: July 2022

The features of patent disputes determine the variety of mechanisms for their consideration and resolution. A review of the Russian and foreign experiences (Germany, Norway, United States, France, Sweden, Japan) show the applicability of various forms of patent rights protection, including administrative and judicial.
Administrative bodies that protect patent rights generally include divisions of patent offices and other executive authorities.
In the judicial systems of the states under review, special judicial structures function in the nature of courts with general competence to consider civil cases, while specialized courts for the protection of intellectual property rights including patents have been created.
The authors conclude that in the modern period, the arbitration and mediation of patent disputes are becoming increasingly widespread, offering a number of advantages, including confidentiality of the case and the necessary level of specialization of arbitrators (mediators). At the same time, however, it is hindered by the lack of uniformity in resolving the issue of the arbitrability of patent disputes.
Federal guidelines on diagnosis and treatment of bronchial asthma
Authors: Chuchalin A. G. , Avdeev S. N. , Aisanov Z. R. , Belevskiy A. S. , Vasil’eva O. S. , Geppe N. A. , Ignatova G. L. , Knyazheskaya N. P. , Malakhov A. B. , Meshcheryakova N. I. , Nenasheva N. M. , Fassakhov R. S. , Khaitov R. M. , Il’ina N. I. , Kurbacheva O. M. , Astafieva N. G. , Demko I. V. , Fomina D. S. , Namazova-Baranova L. S. , Baranov A. A. , Vishneva E. A. , Novik G. A. 
Published: July 2022

Bronchial asthma is a heterogeneous disease that requires identification of its phenotype and a personalized approach to therapy. At the same time, despite a wide range of therapeutic options, many patients with asthma cannot achieve control over the disease.Methodology. The target audience of these clinical recommendations are general practitioners, therapists, pediatricians, allergologists-immunologists, pulmonologists, and functional diagnostics doctors. Each thesis-recommendation about diagnostic and therapeutic procedures has been scored according to the scales of classes of recommendations from 1 to 5 and A, B, C scale of the levels of evidence. The clinical recommendations also contain comments and explanations to the theses, algorithms for the diagnosis and treatment of bronchial asthma, and reference materials.Conclusion. The presented clinical guidelines cover current information about the etiology and pathogenesis, classification, clinical manifestations, diagnosis, treatment, and prevention of bronchial asthma. These guidelines were approved by the Scientific and Practical Council of the Ministry of Health of the Russian Federation in 2021.
STRENGTHENING RELIGIOUS MODERATION THROUGH FABLE ACTIVITIES IN EARLY CHILDHOOD
Authors: Azizah Qorina 
Published: July 2022

Abstract
The invitation to become enmity and hostile to adherents of other religions and beliefs is phenomenal that strengthens today. Intolerance and radicalism that pursue violence and social conflict are increasingly arbitrary. This hostility occurs in the education section, where teachers and students are faced with issues that are contrary to the values ​​of Pancasila and religious norms. Religious moderation is an effort to instill peace-loving values ​​in students as an effort to de-radicalize religious education, especially Islamic religious education. To achieve it, Islamic religious education is present and participated in it. To explore data through various literature or literature studies, a qualitative descriptive study was conducted to find a picture of reinforcing patterns in natural religious education and to instill a peace-loving attitude in early childhood. This study found that a comprehensive, basic, or deep and ingrained understanding of the concept of peace and non-loyalty about choice but based it basically should be instilled in every child. In an effort to improve the background or related curriculum and commitment to applying a peace-loving attitude, the storytelling method is used in early childhood.
Core areas in the structure of the regional ecological framework of Sevastopol City
Authors: Milchakova N. A., , Bondareva L. V. , Alexandrov V. V. 
Published: July 2022

Aim. To identify land and water areas for inclusion in the regional ecological framework of Sevastopol City and to define the core areas for ensuring the representative character of the nature protection network and the ecological stability of the region.Material and Methods. Based on field surveys, archival and published data, the structure of the ecological framework of Sevastopol was specified as a part of the Crimean ecological network, developed in 2008. A schematic map of the protected areas and ecological framework elements was developed and calculation of their area carried out using the QGIS‐3.10.10. The index of environmental significance was calculated according to Guryevskikh and a scale for its gradation was suggested. For ecological centres and corridors, the ratio of key areas of the first and second order was analyzed.Results. The creation of 34 protected areas was proposed and their conservation value was shown. The boundaries of the core areas and 11 structural elements of the ecological framework were specified, its representativeness was characterized and problems of its implementation were discussed. As a result of optimization of the nature protection network of Sevastopol, the share of the protected areas and ecological framework of the total area of the city will be increased to 37.1 and 66%, respectively. A complex of conservational measures has been proposed for the protection of populations and biotopes of rare species included in the Red Data Book of Sevastopol.Conclusions. The creation of new core areas and the optimisation of the nature conservation network will ensure the maintenance of the sustainability of the ecological framework and the ecological stability of the region but will not make significant changes to the previously formed disproportion due to the impossibility of creating large objects with a high category of protection. The implementation of the ecological framework project will help to reduce the risk of losing the biological and landscape diversity of the region.
Age structure and condition assessment of Fagus orientalis Lipsky in the Caucasian Ecoregion
Authors: Aliev Kh. U. 
Published: July 2022

Aim. To determine the age structure and assess the current state of Fagus orientalis Lipsky in the Caucasian Ecoregion. Material and Methods. The material was collected in beech forests in different floristic districts of the Caucasian Ecoregion. The registration of individual specimens was carried out on 121 test sites, with a total area of 73925 m2. A total of 19936 individuals of Fagus orientalis were involved in the analysis. Each individual was assessed by condition and assigned to a certain age group.Results. The study of the age structure of Fagus orientalis in the beech forests of the Caucasian Ecoregion showed a similar pattern of distribution of age group participation in all the studied areas studied. The age spectra revealed are left‐sided and full‐membered where individuals of the pregenerative phase predominate. For all populations, in general, almost the same share of the contribution of individuals of germinal and virginal age groups was noted, amounting to about 50% in total. On average, there are 2906 individuals per 1 ha, of which 459 have reached the generative phase. The condition of individuals of the pre‐generative and generative phases across all the botanical areas of the Caucasian Ecoregion studied was estimated by us at 1.47 points.Conclusions. The study of the age structure of populations and the assessment of the condition of individuals allows us to assess the influence of certain abiotic and biotic factors. Low values of the proportion of postgenerative individuals are the result of anthropogenic load in easily accessible territories. Under the influence of processes of intra‐ and interspecific competition, the share of participation of virginal and postgenerative groups increases and is especially clearly observed in beech elfin‐woodlands.
Distribution of bottom vegetation of the shallow water zone in Karkinitskiy Bay of the Crimean Peninsula
Authors: Pankeeva T. V. , Mironova N. V. , Goryachkin Yu. N. , Kharitonova L. V. 
Published: July 2022

Aim. To identify the distribution features of a key species of macrophytobenthos in the shallow water zone of Karkinitskiy Bay.Material and Methods. The field materials from a comprehensive expedition carried out during the summer 2019 were collected and processed by the authors.Results. For the first time, a map was compiled and the features of the distribution of dominant types of macrophytobentos identified in the shallow water zone of Karkinitskiy Bay.Conclusion. It was shown that in the eastern part of the bay, on a shallow slope composed of silty‐sandy deposits, adjacent to the accumulative shores, sea grasses dominate and along the abrasive‐clay shores there is no bottom vegetation and significant accumulations of dead leaves of Zostera marina и Z. noltei are typical there. In the water area of the Bakal spit macrophitobentos is not found on the sandy deposits. Cladophora spp. are represented in the base of the western branch of the spit, at the place of its joining an active clayey cliff. Mosaic distribution of bottom vegetation is noted in the area of Cape Kamenniy, where co‐growth of algae on the limestone outcrops and marine herbs living on loose soils is registered. West of Cape Kamenniy in shallow water adjacent to the abrasive limestone coasts Carpodesmia crinite – Treptacantha barbata phytocenoses are characteristic. It was shown that in the composition of macrophytobentos decreased in the role of dominant species, an increase in the proportion of algae found in the areas with increased eutrophication of marine environment, which is probably due to the influence of anthropogenic and natural factors. Monitoring observations in this area will make it possible to develop scientifically based recommendations aimed at optimizing the environmental regime and rational environmental management of the coastal zone of Karkinitskiy Bay.
Inhibitory activity of tea compositions and their constituent ingredients on SARS‐COV‐2 replication in vitro
Authors: Каzachinskaia Е. I. , Chepurnov А. А. , Коnonova Yu. V. , Shelemba А. А. , Romanyuk V. V. , Magomedov M. G. , Shestopalov А. М. 
Published: July 2022

Aim. In vitro analysis of the inhibitory activity of aqueous extracts of ready‐made tea compositions and their constituent ingredients on SARSCOV‐ 2 replication.Material and Methods. The laboratory strain SARS‐CoV‐ 2/human/RUS/Nsk‐FRCFTM‐1/2020 was passivated on Vero cell culture. For the preparation of water extracts six types of experimental tea compositions (not containing flavorings) based on black and green tea or flowers of hibiscus as well as individual ingredients were used. Antiviral (inhibitory) activity of plant raw materials was studied in vitro according to the classical scheme of neutralization (inactivation) of the virus.Results. When compared with the main control sample of an aqueous extract of chaga (Inonotus obliquus) with a 50% effective concentration equal to 13.72±2.99 μg/ml against 103 TCPD50/ml of SARS‐CoV‐2, superior activity was found for extracts of the spice Syzygium aromaticum L. and black tea from Nepal. Approximately equal inhibitory activity was detected for extracts of tea compositions based on black tea with the addition of the grass Thymus altaicus and the spice S. aromaticum L. or with the addition of seeds of Carum carvi L. and the root of Angelica archangelica L. In addition, such activity was detected for extracts of tea compositions based on green tea from China with the addition of leaves of Mentha piperita L. and flowers of Lavandula angustifolia MILL. or with the addition of the peel of Citrus sinensis L. and seeds of Pimpinella anisum L. Extracts from individual plant raw materials used to make tea compositions were black teas from India, Argentina, Vietnam and Sri Lanka, leaves of M. piperita L. and flowers of L. angustifolia MILL. Cetraria islandica lichen, green tea and berries of Oxycoccus also showed antiviral activity.Conclusion. The results obtained suggest that tea compositions based on black and green tea with the addition of various plant raw materials in the form of a regular drink can be useful to people with COVID‐19 infection.