bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nature, smells, and human wellbeing
Authors: Bentley Phoebe R. , Fisher Jessica C. , Dallimer Martin , Fish Robert D. , Austen Gail E. , Irvine Katherine N. , Davies Zoe G. 
Published: July 2022

AbstractThe link between nature and human wellbeing is well established. However, few studies go beyond considering the visual and auditory underpinnings of this relationship, even though engaging with nature is a multisensory experience. While research linking smell to wellbeing exists, it focuses predominantly on smells as a source of nuisance/offence. Smells clearly have a prominent influence, but a significant knowledge gap remains in the nexus of nature, smell, and wellbeing. Here, we examine how smells experienced in woodlands contribute to wellbeing across four seasons. We show that smells are associated with multiple wellbeing domains, both positively and negatively. They are linked to memories, and specific ecological characteristics and processes over space/time. By making the link between the spatiotemporal variability in biodiversity and wellbeing explicit, we unearth a new line of enquiry. Overall, the multisensory experience must be considered by researchers, practitioners, policy-makers and planners looking to improve wellbeing through nature.
Preliminary functional results after transanal irrigation in patients undergoing SHiP procedure for low rectal cancer
Authors: Bianco Francesco , Grassia Sebastiano , Goglia Marta , Gallo Gaetano 
Published: July 2022

AbstractThe short-stump and high-anastomosis pull-through procedure (SHiP) is a newly introduced technique in the treatment of rectal cancer. This procedure does not involve the creation of a diverting ostomy with great improvement of the patients’ quality of life in the post-operative period. However, functional post-operative alterations such as low anterior rectal resection syndrome (LARS) may occur. In this context, trans-anal irrigation (TAI) may represent a viable option in the treatment and management of LARS symptoms. The aim of the present study is to investigate the role of TAI in patients operated on SHiP procedure for low rectal cancer. A prospective database of 17 patients who underwent a SHiP procedure was maintained from April 2019 to December 2021. Anal continence and functional outcomes were assessed through LARS score and Cleveland Clinic Incontinence Score (CCIS), respectively. All patients with a LARS score > 21 underwent TAI in the post-operative period. LARS median value was 36 (IQR = 8) and drastically improved after TAI treatment to 3 (IQR = 3), as the CCIS at a mean follow-up of 9 months (SD ± 5.02). Good functional result was reached in 12 out of 13 patients (92%). Our study confirms that patients with severe post-operative dysfunction could benefit from the use of TAI.
EV-miRome-wide profiling uncovers miR-320c for detecting metastatic colorectal cancer and monitoring the therapeutic response
Authors: Yang Chan-Keng , Hsu Hung-Chih , Liu Yu-Hao , Tsai Wen-Sy , Ma Chung-Pei , Chen Yi-Tung , Tan Bertrand Chin-Ming , Lai Ying-Yu , Chang Ian Yi-Feng , Yang Chi , Yang Chia-Yu , Yu Jau-Song , Liu Hsuan 
Published: July 2022

Abstract
Purpose
Molecular composition of circulating small extracellular vesicles (EVs) does not merely reflect the cells of origin, but also is enriched in specific biomolecules directly associated with the cellular transformation. However, while most of the currently identified EV-miRs are only geared towards one-dimensional disease detection, their application for long-term tracking and treatment response monitoring has been largely elusive.

Methods
We established and optimized a rapid, sensitive and robust liquid biopsy sampling method, and further used small RNA sequencing to comprehensively catalogue EV-miRomes in association with the progression and outcome of metastatic colorectal cancer (mCRC).

Results
By cross-comparison of EV-miRomes (n = 290) from multi-stage and longitudinal cohorts, we uncovered a 15-EV-miR signature with dual detection and long-term monitoring of tumor size progression for mCRC. From this panel, EV-miR-320c was uncovered as a strong clinical marker – aside from its diagnostic power and a therapeutic monitoring performance superior to carcinoembryonic antigen (CEA), its high expression has also been linked to lower overall survival and a greater likelihood of disease recurrence. Further, integrative analyses of tissue transcriptomic and liquid biopsy implicated this 15-EV-miR signature in programming the mesenchymal–epithelial transition (MET) for distant localization of the metastasized cells and also in creating a tumor-favoring metastatic niche.

Conclusion
Our clinically-oriented delineation of the mCRC-associated circulating EV-miRomes systematically revealed the functional significance of these liquid biopsy markers and further strengthen their translational potential in mCRC therapeutic monitoring.

Graphical abstract
An integrated distribution scheduling and route planning of food cold chain with demand surge
Authors: Chen Youhua , Lan Hongjie , Wang Chuan , Jia Xiaoqiong 
Published: July 2022

AbstractWith the rapid development of e-commerce, customers could order online to ensure timeliness. Therefore, e-commerce enterprises need to pick and distribute customers’ orders. These two operations are interdependent. Order picking needs to consider the vehicle route planning. At the same time, the vehicle route planning is also based on the batching of orders. Considering the demand surge scenario of food cold chain, with the shortest time and lowest cost to complete all distribution tasks as the objective, this paper aims at the integrated optimization of distribution scheduling and route planning, and establishes a mixed integer programming mathematical model. Finally, we design a three-stage heuristic algorithm to solve this problem, and use the actual data to carry out numerical experiments to verify the reliability and effectiveness of the mathematical model and heuristic algorithm.
Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy
Authors: Bai Shuang , Lan Yulu , Fu Shiying , Cheng Hongwei , Lu Zhixiang , Liu Gang 
Published: July 2022

AbstractAs the indispensable second cellular messenger, calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins. The importance of calcium ions (Ca2+) makes its “Janus nature” strictly regulated by its concentration. Abnormal regulation of calcium signals may cause some diseases; however, artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role. “Calcium overload,” for example, is characterized by excessive enrichment of intracellular Ca2+, which irreversibly switches calcium signaling from “positive regulation” to “reverse destruction,” leading to cell death. However, this undesirable death could be defined as “calcicoptosis” to offer a novel approach for cancer treatment. Indeed, Ca2+ is involved in various cancer diagnostic and therapeutic events, including calcium overload-induced calcium homeostasis disorder, calcium channels dysregulation, mitochondrial dysfunction, calcium-associated immunoregulation, cell/vascular/tumor calcification, and calcification-mediated CT imaging. In parallel, the development of multifunctional calcium-based nanomaterials (e.g., calcium phosphate, calcium carbonate, calcium peroxide, and hydroxyapatite) is becoming abundantly available. This review will highlight the latest insights of the calcium-based nanomaterials, explain their application, and provide novel perspective. Identifying and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics.
A comparison between carbon footprint of water production facilities in the Canary Islands: groundwater resources vs. seawater desalination
Authors: Cruz-Pérez Noelia , Santamarta Juan C. , Gamallo-Paz Isabel , Rodríguez-Martín Jesica , García-Gil Alejandro 
Published: July 2022

AbstractThe Canary Islands have a water culture tied to the exploitation of their groundwater by means of wells and water galleries. However, the growth of tourism, the increase in the local population and the development of agriculture have led to the emergence of new ways of obtaining water, such as the desalination of seawater. The presence of these desalination plants covers the entire archipelago except for the island of La Palma, and sometimes they function as a complement to water needs, while in other cases they are the only source of drinking water available. To study the environmental impact of the production of drinking water through the exploitation of the aquifer and the desalination of seawater, the carbon footprint methodology was used following the guidelines of the GHG Protocol. The result has shown that seawater installations have the largest carbon footprint, mainly due to the high electricity consumption in the islands and the electricity mix of the archipelago which, as it does not rely entirely on renewable energy sources, increases CO2 emissions into the atmosphere due to the production of drinking water in the islands.
Integral Real-time Locomotion Mode Recognition Based on GA-CNN for Lower Limb Exoskeleton
Authors: Wang Jiaqi , Wu Dongmei , Gao Yongzhuo , Wang Xinrui , Li Xiaoqi , Xu Guoqiang , Dong Wei 
Published: July 2022

AbstractThe wearable lower limb exoskeleton is a typical human-in-loop human–robot coupled system, which conducts natural and close cooperation with the human by recognizing human locomotion timely. Requiring subject-specific training is the main challenge of the existing approaches, and most methods have the problem of insufficient recognition. This paper proposes an integral subject-adaptive real-time Locomotion Mode Recognition (LMR) method based on GA-CNN for a lower limb exoskeleton system. The LMR method is a combination of Convolutional Neural Networks (CNN) and Genetic Algorithm (GA)-based multi-sensor information selection. To improve network performance, the hyper-parameters are optimized by Bayesian optimization. An exoskeleton prototype system with multi-type sensors and novel sensing-shoes is used to verify the proposed method. Twelve locomotion modes, which composed an integral locomotion system for the daily application of the exoskeleton, can be recognized by the proposed method. According to a series of experiments, the recognizer shows strong comprehensive abilities including high accuracy, low delay, and sufficient adaption to different subjects.
How User Manuals Support the Diagnosis of Common Faults in Household Appliances: an Analysis of 150 Manuals
Authors: Pozo Arcos Beatriz , Bakker Conny , Balkenende Ruud 
Published: July 2022

Abstract
Product repairs are at the core of sustainable consumption and user manuals can play a relevant role in facilitating them. They are the accredited source of product information for end users and are therefore sought as an important means for the diagnosis and subsequent repair of household appliances. However, despite increasing societal demand for repairable products, few studies have been conducted on the extent to which manuals contribute to the fault diagnosis and subsequent repair process. In this study, we analysed current guidance provided by manuals for the diagnosis process, answering the research question: ‘To what extent do user manuals provide sufficient information to diagnose the most frequent faults in household appliances?’ We examined the diagnosis instructions provided in the user manuals of four different household appliances using data on the appliances’ most frequently failing components, and a framework that considers three steps towards a successful diagnosis: fault detection, fault location, and fault isolation. In total, we analysed 150 user manuals of 48 brands available on the European market. We show that manuals do not instruct the diagnosis of frequently failing components. They mainly refer to causes of failure and directly recommend corrective actions after fault detection. Thus, they rarely include a three-step fault diagnosis process to identify and isolate a faulty component. Based on these results, we have extended the framework for the process of fault diagnosis to include a step from cause identification to corrective action. Both routes, the component-oriented and the cause-oriented route in fault diagnosis, should be considered during the design of products for easy fault diagnosis, and should be included in future regulations that address product reparability.
Woody species in the urban schoolyards in West Africa Sahel cities in Niger: diversity and benefits for green schools
Authors: Soulé Moussa , Nyamekye Clement , Abdoul-Azize Hamidou Taffa 
Published: July 2022

AbstractUrban schoolyards are essential in biodiversity conservation; they provide numerous ecosystem services to students, school managers, and the city where the schools are located. However, limited or no studies have explored the role of urban schoolyards in both biodiversity conservation and carbon sequestration. This study, therefore, assessed the structure and values of urban schoolyards forest in the cities of Niamey and Maradi in the Niger Republic. A total of 60 schools was selected purposively from Maradi and Niamey (30 schools in each city), where the data were collected through a face-to-face survey. Additionally, a forest inventory and participatory observations were conducted to gather the dendrometric data and animal biodiversity. The findings revealed that, a total of 97 different tree species belonging to 35 families and 81 genera. In addition, neem tree and Fabaceae (22 species) were found to be the dominant tree species and botanical family respectively in the schoolyards of both cities. The similarity index was 64% indicating high similarity between the floras of the schoolyards in the two cities. The biomass value equals about 48.91 t/ha and 27.49 t/ha carbon stock in the primary schools of Niamey and Maradi respectively. Furthermore, the analysis of the structure of the urban schoolyard forests showed high values of structural parameters indicating the vitality/health/integrity of the forest. The ability of students to name plants, animals, and ecosystem services of their schoolyards is significantly low. This study recommends the use of multipurpose woody plant species in urban greening school initiatives for quality education. Furthermore, the study recommends a further investigation of the effects of the school urban forest structure on the students' academic performance and the allergenic potential of woody species found in urban schools.
What’s the Plan? Exploring the Bounds of a Health-Care Standard of Preparedness for Florida Hospitals: A Policy Analysis
Authors: Connor Courtney Lee 
Published: July 2022

AbstractHurricane Katrina uncovered a potential new theory of liability for the health-care industry—failure to plan. Today, the issue remains unresolved: how does a hospital define its duty of preparedness? Research shows there are over 13 definitions for hospital preparedness, multiple types of risk, and arbitrary hospital assessment tools that are not based on empirical data. In the absence of a clear definition for health-care preparedness, this article proposes a “reasonable under the circumstances” test to evaluate alleged liability for failure to plan and similar claims of negligence. In addition, translational science is proposed to aid in the development of a health-care standard of preparedness through a 5-phase evidenced-based, multi-disciplinary process.
Identifying the Challenges of Simulating the Hospital Emergency Department in the Event of Emergencies and Providing Effective Solutions: A Qualitative Study
Authors: Barghi Shirazi Fahimeh , Moslehi Shandiz , Rasouli Mohammad Reza , Masoumi Gholamreza 
Published: July 2022

AbstractIntroduction:Emergencies and disasters occur in any society, and it is the hospitals and their emergency department staff who must be prepared in such cases. Therefore, 1 of the effective methods of training medical care staff is the use of simulators. However, when introducing new simulation approaches, we face many challenges. The aim of this study was to identify challenges of the simulation of the hospital emergency department during disasters and provide effective solutions.Methods:This conventional content, thematic, analysis study was conducted in 2021. Participants were selected from Iranian experts using purposeful and snowball sampling methods. Data were collected using semi-structured interviews and were analyzed by the content analysis.Results:After analyzing the data, the challenges of simulating the hospital emergency department during disasters were identified in 2 main components and 6 perspectives, which included organizational components (inappropriate and aimless training methods, lack of interaction and cooperation, lack of funding, and inadequate physical space) and technological components (weak information management and lack of interdisciplinary cooperation). Solutions included management (resource support) and data sharing and exchange (infrastructures, cooperation and coordination).Conclusion:The simulation technology can be used as a method for training and improving the quality of health care services in emergencies. Considering that most of these challenges can be solved and need the full support of managers and policy makers, by examining these issues, supporting staff of health care centers are advised to make a significant contribution to the advancement of education and problem reduction in the event of disasters.
Egoism and Class Consciousness, or: Why Marx and Engels Wrote So Much About Stirner
Authors: Whyman Tom 
Published: July 2022

AbstractInterest inThe German Ideologyhas largely focused on the ‘chapter’ on Feuerbach—invariably the focus of the various abridgements in which the work is usually read. But this does not reflect the weighting of the text itself, which is dominated by Marx and Engels's critique of the radical egoist philosopher Max Stirner. Which begs the question: just why did they spend so much time and effort writing about Stirner? In this paper, I will provide an answer—which comes down to three related points. The first concerns the critique of reason; the second, egoistic self-interest. On both of these two points, Stirner makes a novel contribution—contributions which Marx and Engels feel clear affinities with. However, Stirner can ultimately be seen to get these two points, as it were,the wrong way around. This then leads to the third point: Stirner's misunderstanding of the nature of Communism. To clarify the nature of Communism, then, Marx and Engels were compelled to turn Stirner on his head.
Surgical site infection trends in community hospitals from 2013 to 2018
Authors: Seidelman Jessica L. , Baker Arthur W. , Lewis Sarah S. , Advani Sonali D. , Smith Becky , Anderson Deverick ,   for the Duke Infection Control Outreach Network Surveillance Team
Published: July 2022

AbstractObjective:Sparse recent data are available on the epidemiology of surgical site infections (SSIs) in community hospitals. Our objective was to provide updated epidemiology data on complex SSIs in community hospitals and to characterize trends of SSI prevalence rates over time.Design:Retrospective cohort study.Methods:SSI data were collected from patients undergoing 26 commonly performed surgical procedures at 32 community hospitals in the southeastern United States from 2013 to 2018. SSI prevalence rates were calculated for each year and were stratified by procedure and causative pathogen.Results:Over the 6-year study period, 3,561 complex (deep incisional or organ-space) SSIs occurred following 669,467 total surgeries (prevalence rate, 0.53 infections per 100 procedures). The overall complex SSI prevalence rate did not change significantly during the study period: 0.58 of 100 procedures in 2013 versus 0.53 of 100 procedures in 2018 (prevalence rate ratio [PRR], 0.84; 95% CI, 0.66–1.08; P = .16). Methicillin-sensitive Staphylococcus aureus (MSSA) complex SSIs (n = 480, 13.5%) were more common than complex SSIs caused by methicillin-resistant S. aureus (MRSA; n = 363, 10.2%).Conclusions:The complex SSI rate did not decrease in our cohort of community hospitals from 2013 to 2018, which is a change from prior comparisons. The reason for this stagnation is unclear. Additional research is needed to determine the proportion of or remaining SSIs that are preventable and what measures would be effective to further reduce SSI rates.
A hierarchical network densification approach for reconstruction of historical ice velocity fields in East Antarctica
Authors: Feng Tiantian , Li Yanjun , Wang Kangle , Qiao Gang , Cheng Yuan , Yuan Xiaohan , Luo Shulei , Li Rongxing 
Published: July 2022

AbstractAccurate ice flow velocity data are essential for studying the mass balance of the Antarctic ice sheet. However, there is a lack of ice velocity maps of 1960s–80s in basin-wide regions or the entire ice sheet. In this study, an enhanced hierarchical network densification approach is developed for basin-wide Antarctic velocity mapping using historical ARGON and Landsat images. The produced multiple historical velocity maps from 1963 to 1989 in the region of the Fimbul and Jelbart ice shelves, East Antarctica, achieved an accuracy better than 29 m a−1. They revealed that the ice flow velocity had no significant changes over the period. Combining the surface mass balance estimate with the ice discharge estimated from our historical velocity maps and recently published velocity maps, we estimated a positive mass balance of 8.6 ± 3.9 Gt a−1 in the study area from 1963 and 2015. Our results indicate that the region's positive mass balance, as estimated in recently published studies, has been maintained since the 1960s. It is also in concordance with the low level of mass balance from 1992 to 2017 in East Antarctica. This suggests that the study area has been stable since the 1960s.
The larval brachyopid Platycepsion wilkinsoni from the Triassic of New South Wales provides insight into the stereospondyl life cycle
Authors: Witzmann Florian , Schoch Rainer R. 
Published: July 2022

AbstractThe small, immature brachyopid stereospondyl Platycepsion wilkinsoni from the Early or Middle Triassic of Gosford, New South Wales, is redescribed from a developmental point of view. Whereas the sutural contact between postorbital and parietal suggested by earlier authors cannot be confirmed, a new autapomorphy, the posterior process of the interclavicle with a slightly concave posterior margin, is recognized. A further apomorphic state may be the probable presence of five pairs of ossified ceratobranchials. Soft-tissue preservation of external gills demonstrates that Platycepsion wilkinsoni represents a true larva, forming the first evidence of a larval stage in stereospondyls. Morphology and developmental stage of Platycepsion wilkinsoni indicates that brachyopids conserved the plesiomorphic ontogenetic pattern seen in most Paleozoic temnospondyls, including the early ossification of the dermal skull roof and delayed ossification of the postcranium. The strongly developed ornament, the widened lateral lines, and the well-ossified exoccipitals and stapes suggest an even faster ossification and differentiation of the skull compared to Paleozoic temnospondyls and might represent a general stereospondyl characteristic. In the vertebral column, only the poorly differentiated, still separate neural arches are ossified, whereas the centra remained cartilaginous. This implies that the plesiomorphic pattern of vertebral development was conserved in Mesozoic stereospondyls, irrespective of whether the adult vertebral morphology was rhachitomous, stereospondylous, or diplospondylous. The low degree of ossification of the postcranium, its slow differentiation, and the delayed development of the scapulocoracoid indicate an aquatic mode of life, and the strongly ossified skull and hyobranchial apparatus suggest an emphasis on powerful suction feeding.