bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antisense lncRNA PCNA-AS1 promotes esophageal squamous cell carcinoma progression through the miR-2467-3p/PCNA axis
Authors: Hu Tao , Niu Yunfeng , Fu Jianfeng , Dong Zhiming , He Dongwei , Liu Junfeng 
Published: September 2022

Abstract
Multiple studies have indicated that long non-coding RNAs are aberrantly expressed in cancers and are pivotal in developing various tumors. No studies have investigated the expression and function of long non-coding antisense RNA PCNA-AS1 in esophageal squamous cell carcinoma (ESCC). In this study, the expression of PCNA-AS1 was identified by qRT–PCR. Cell function assays were used to explore the potential effect of PCNA-AS1 on ESCC progression. A prediction website was utilized to discover the relationships among PCNA-AS1, miR-2467-3p and proliferating cell nuclear antigen (PCNA). Dual luciferase reporter gene and RNA immunoprecipitation (RIP) assays were executed to verify the binding activity between PCNA-AS1, miR-2467-3p and PCNA. As a result, PCNA-AS1 was highly expressed in ESCC and was associated with patient prognosis. PCNA-AS1 overexpression strongly contributed to ESCC cell proliferation, invasion and migration. PCNA-AS1 and PCNA were positively correlated in ESCC. Bioinformatics analysis, RIP and luciferase reporter gene assays revealed that PCNA-AS1 could act as a competitive endogenous RNA to sponge miR-2467-3p, thus upregulating PCNA. In conclusion, the current outcome demonstrates that PCNA-AS1 may be a star molecule in the treatment of ESCC.
Core–shell structured magnetic MCM-41-type mesoporous silica-supported Cu/Fe: A novel recyclable nanocatalyst for Ullmann-type homocoupling reactions
Authors: Abdollahi-Alibeik Mohammad , Ramazani Zahra 
Published: September 2022

Abstract
In this study, a novel magnetic MCM-41-type mesoporous silica-supported Fe/Cu (Fe3O4@Fe–Cu/MCM-41) was prepared, characterized, and used as a heterogeneous catalyst for the synthesis of symmetric biaryls by Ullmann cross-coupling reaction. This nanocomposite was characterized using Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and nitrogen adsorption–desorption isotherm. The Fe3O4@Fe–Cu/MCM-41 was applied as an efficient catalyst in the synthesis of biaryls under optimum conditions. This nanocatalyst was recovered and reused several times without significant loss of activity.
Das Bildarchiv des Bruckmann Verlags
Authors: Lampe Franziska 
Published: September 2022

Abstract
Mit dem historischen Bildarchiv des Bruckmann Verlags in München hat sich der fotografische Quellenbestand einer der größten deutschen Verlags- und Druckanstalten erhalten. Diese in sich geschlossene Sammlung gelangte im Herbst 2016 an das Zentralinstitut für Kunstgeschichte (ZI) in München. Der circa 150 000 fotografische Medieneinheiten umfassende Bestand zeichnet sich durch eine große materielle und motivische Diversität aus und ist über eine Zeitspanne von circa 1860 bis in die 1990er Jahre entstanden. Das Archiv besteht aus Positiven und Negativen, die Reproduktionen von Kunstwerken vor allem der Malerei, Skulptur sowie Architektur zeigen und sich auch durch ihre Retuschen und Annotationen aus dem verlegerischen Arbeitsprozess als besondere Forschungsgegenstände ausweisen. Das historische Bildarchiv galt lange Zeit als nicht mehr existent und steht nun erstmals der Wissenschaft zur Verfügung.
Mesostructural Mechanism of Hydraulic Gradient Fluctuations Affecting Internal Instability Using Transparent Soil
Authors: Deng Zezhi , Wang Gang , Jin Wei 
Published: September 2022

Abstract
For internally unstable soil, fine particles might migrate in the pore channels of its coarse matrix because of seepage flow, and fluctuations in the hydraulic gradient might promote this migration. To reveal the mechanism for this behavior, simulation testing using transparent soil was employed to visualize the soil mesostructure and particle migration process. Three gap-graded transparent soils with internal stability ranging from unstable to marginally stable and stable were made by mixing different amounts of fine particles. First, comparative seepage tests were conducted on the three soils under steady and fluctuating hydraulic conditions. The effect of hydraulic fluctuations depends on the internal stability of the soil. For the internally unstable or marginally stable soils, hydraulic fluctuations promoted internal instability, whereas for the internally stable soil, small applied hydraulic fluctuations had negligible effects on the measured hydraulic characteristics. Particle bridging during the migration process was used to explain the different behaviors. To verify this concept, a two-stage seepage test was performed, and a three-dimensional digital mesostructural model of the specimen was reconstructed based on continuously scanned images of cross sections. The comparison of the digital models at different stages provided visual evidence of particle bridging. It clearly showed that fine particles bridged at some pore constrictions, and the bridges remained intact during the first steady seepage stage and blocked particle migration paths. During the subsequent fluctuating seepage stage, these particle bridges disappeared, and particle migration resumed.
Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis
Authors: Dong Chen , Zhao Chuntao , Chen Xiang , Berry Kalen , Wang Jiajia , Zhang Feng , Liao Yunfei , Han Rong , Ogurek Sean , Xu Lingli , Zhang Li , Lin Yifeng , Zhou Wenhao , Xin Mei , Lim Daniel A. , Campbell Kenneth , Nakafuku Masato , Waclaw Ronald R. , Lu Q. Richard 
Published: September 2022

The chromatin remodeler CHD8 represents a high-confidence risk factor in autism, a multistage progressive neurologic disorder, however the underlying stage-specific functions remain elusive. In this study, by analyzingChd8conditional knock-out mice (male and female), we find that CHD8 controls cortical neural stem/progenitor cell (NSC) proliferation and survival in a stage-dependent manner. Strikingly, inducible genetic deletion reveals that CHD8 is required for the production and fitness of transit-amplifying intermediate progenitors (IPCs) essential for upper-layer neuron expansion in the embryonic cortex. p53 loss of function partially rescues apoptosis and neurogenesis defects in theChd8-deficient brain. Further, transcriptomic and epigenomic profiling indicates that CHD8 regulates the chromatin accessibility landscape to activate neurogenesis-promoting factors including TBR2, a key regulator of IPC neurogenesis, while repressing DNA damage- and p53-induced apoptotic programs. In the adult brain, CHD8 depletion impairs forebrain neurogenesis by impeding IPC differentiation from NSCs in both subventricular and subgranular zones; however, unlike in embryos, it does not affect NSC proliferation and survival. Treatment with an antidepressant approved by the Federal Drug Administration (FDA), fluoxetine, partially restores adult hippocampal neurogenesis inChd8-ablated mice. Together, our multistage functional studies identify temporally specific roles for CHD8 in developmental and adult neurogenesis, pointing to a potential strategy to enhance neurogenesis in the CHD8-deficient brain.SIGNIFICANCE STATEMENTThe role of the high-confidence autism geneCHD8in neurogenesis remains incompletely understood. Here, we identify a stage-specific function of CHD8 in development of NSCs in developing and adult brains by conserved, yet spatiotemporally distinct, mechanisms. In embryonic cortex, CHD8 is critical for the proliferation, survival, and differentiation of both NSC and IPCs during cortical neurogenesis. In adult brain, CHD8 is required for IPC generation but not the proliferation and survival of adult NSCs. Treatment with FDA-approved antidepressant fluoxetine partially rescues the adult neurogenesis defects in CHD8 mutants. Thus, our findings help resolve CHD8 functions throughout life during embryonic and adult neurogenesis and point to a potential avenue to promote neurogenesis in CHD8 deficiency.
Human SFI1 and Centrin form a complex critical for centriole architecture and ciliogenesis
Authors: Laporte Marine H , Bouhlel Imène B , Bertiaux Eloïse , Morrison Ciaran G , Giroud Alexia , Borgers Susanne , Azimzadeh Juliette , Bornens Michel , Guichard Paul , Paoletti Anne , Hamel Virginie 
Published: September 2022

AbstractOver the course of evolution, the centrosome function has been conserved in most eukaryotes, but its core architecture has evolved differently in some clades, with the presence of centrioles in humans and a spindle pole body (SPB) in yeast. Similarly, the composition of these two core elements has diverged, with the exception of Centrin and SFI1, which form a complex in yeast to initiate SPB duplication. However, it remains unclear whether this complex exists at centrioles and whether its function has been conserved. Here, using expansion microscopy, we demonstrate that human SFI1 is a centriolar protein that associates with a pool of Centrin at the distal end of the centriole. We also find that both proteins are recruited early during procentriole assembly and that depletion of SFI1 results in the loss of the distal pool of Centrin, without altering centriole duplication. Instead, we show that SFI1/Centrin complex is essential for centriolar architecture, CEP164 distribution, and CP110 removal during ciliogenesis. Together, our work reveals a conserved SFI1/Centrin module displaying divergent functions between mammals and yeast.
Detection of ESBL and AmpC producing Klebsiella pneumoniae ST11 and ST147 from urinary tract infections in Iran
Authors: Shahkolahi Shaghayegh , Shakibnia Pegah , Shahbazi Shahla , Sabzi Samira , Badmasti Farzad , Asadi Karam Mohammad Reza , Habibi Mehri 
Published: September 2022

AbstractIn the present study a total of 200 Klebsiella pneumoniae isolates were collected from patients with urinary tract infections (UTIs) in Tehran, Iran. Antibiotic resistance was determined by disk diffusion and broth dilution methods. Detection of extended-spectrum β-lactamases (ESBLs) and AmpCs was performed using phenotypic tests. Polymerase chain reaction (PCR) was applied to detect the ESBL, AmpC, and integron genes. Analysis of AmpC and cassette arrays of integron genes was performed using DNA sequencing. Plasmids were analyzed by PCR-based replicon typing and conjugation. Pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST) were applied to explore the genomic relatedness among the isolates. The highest levels of resistance were observed against ampicillin (100%), followed by piperacillin (57.5%), ceftazidime (46%), trimethoprim/sulfamethoxazole (44%), ciprofloxacin (32.5%), and imipenem (19%). Approximately, 66.5% of isolates harbored at least one of the beta-lactamase genes (blaTEM, blaSHV, blaCTX-M, and blaOXA-1). In addition, 22.5% of isolates carried at least one of the AmpC genes including blaDHA and blaCIT. Integron class I was the most prevalent integron among resistant isolates. According to the results of replicon typing, IncFII, IncL/M, and IncA/C were the most frequent replicons, respectively. All selected isolates were able to transfer blaCTX-M, also two isolates transferred the blaDHA-1 gene to Escherichia coli K12 through conjugation. Finally, 21 isolates were categorized into 4 pulsotypes and 11 unique clusters in PFGE. MLST identified ST147 and ST11 sequence types but ST147 was the most prevalent in the current study.
„Ut pictura meditatio”. A győri volt jezsuita rendház díszlépcsőinek dekorációja a jezsuita Mária-emblematika kontextusában
Authors: Kusler Ágnes 
Published: September 2022

This paper aims towards a contextual analysis of the emblematic decoration of the staircase of the former jesuit (today Benedictine) college in Győr, North-Western hun-gary. The decoration, created in 1697, visualizes the prayer Salve Regina, and its content is closely connected to the jesuit spiritual exercise of meditation. According to my interpretation, the emblems of the staircase offered a visual aid to the jesuit clerks, for their meditations on the significance of holy Mary. The emblems, thus, embody the idea of “Ut pictura meditatio”, as defined by Walter S. Melion.I offer an analysis of the meditational programme of the decoration of the Győr staircase, and a brief outline of its place in late 17th-century devotional emblematics. The source of the emblematic decoration could be found in the context of jesuit emblem literature and applied emblematics. Besides several analogous emblematic publications, according to my research, the visual source for the Győr programme was the Salve regina print-series by the Antwerp artist Anton Wierix. Through an analysis of this source, I aim to distance the interpretation of the staircase’s decoration from the former attempt of Éva Knapp, proposing that the decoration was based on creative visual translations of emblem-descriptions by jacob Masen.Through my interpretation of the emblems and their overall programme, the decoration of the Győr college could be placed in the context of jesuit meditation and applied emblematics. I also aim to elaborate on the practical function of the decorative programme, and thus widening our knowledge on early modern practices of emblematic meditation in monastic communities.
Címereslevelek a Jagelló-kori Magyarországon •
Authors: Mikó Árpád 
Published: September 2022

The introductory part of the study reviews the historiography of research into jagiellonian letters patent of nobility and the art historical problems of the illuminations. a similar survey was compiled sixty years earlier by dénes radocsay. since then several deeds of granting armorial bearings have cropped up, and lots of new data have been found in historical sources about once existing, now lost or latent, letters patent. the introduction is not meant to thoroughly revise dénes radocsay’s groups compiled by style critical criteria, but it touches on several questions solved or seen more clearly now. For example, the mark of an early 16th century buda illuminator’s hand is preserved not only by letters with armorial bearings, but also by three fragmentary liturgical manuscripts, and the oeuvre of the so-called bakócz monogrammist – who painted the coats of arms in the most representative letters patent in greatest numbers during louis ii’s reign – has been considerably extended.A few words about the arrangement of the data in the list. the letters patent follow in chronological order, the years of granting emphasized for better orientation.Vladislav ii’s letters patent arranged by years are followed by a few items that cannot be dated accurately. line one traditionally contains the names of the grantees, modernized – if possible – but not in phonetic transcription gaining ground lately. (i attach the original form of the name in parentheses.) then come dating, measurements, place of preservation and (when known) provenance. the most important data are followed by the list of works in which the given diploma is mentioned. it includes hand-written – 18th and 19th century – mentions, copied texts, as well as items of the modern special literature.
Integrating Quality Features into Technology Acceptance Model for Examining the Acceptance of Mobile Payment Go-Pay
Authors: Djauhari Medina Juniar , Furqon Chairul , Sultan Mokh Adib 
Published: September 2022

Go-Pay was the innovation in Financial Technology offered in efficiency of payment. The main objective of this study was to bring further insights into consumer intentions to use mobile payments Go-Pay it helps improving service quality and increasing user satisfaction of the Go-Jek user. Mobile payment is in a developing stage and consumers are still reluctant and so they hesitate to use mobile payment. Data is collected from Go-Jek user who have used Go-Pay as mobile payment systems in Bandung city. A survey study with the SEM analysis of 200 participants, with four out of six hypothesis are supported. Research results demonstrate that there are significant relationships between service quality and intention to use, there is not significant relationship between perceived ease of use, perceived usefulness to intention to use mobile payment Go-Pay. Keyword. Quality Technology Acceptance Model (QTAM); Intention to Use; Structural Equation Model;
The effects of nefopam hydrochloride and tramadol hydrochloride on postoperative pain in patients undergoing long bone fracture fixations: A randomised triple blinded study
Authors: Dholariya Ravi D , Marviya Jalja , Aggarwal Shubham , Beri Sudhir 
Published: September 2022

Orthopaedic surgery has one of the most painful post-operative periods. Pain management is an important consideration in Orthopaedic department. The purpose of this study was to assess the effect of Nefopam hydrochloride and Tramadol hydrochloride in postoperative analgesia in patients undergoing long bone fracture fixations.Triple blindedRandomization and allocation to study groups were carried out by odd and even number method. The study was conducted in tertiary care center from May 2019 till March 2020.184 patients who underwent Orthopaedic surgery were included in this randomized study. 92 patients were placed each in group-A and B. Patients in group-A received Tramadol hydrochloride and in group-B received Nefopam hydrochloride. The primary outcome measures were pain intensity assessed by using a Visual Analogue Scale (VAS) Score, Verbal Rating Scale (VRS) score whereas the secondary outcome measures included side effects related to the drugs and number of patients who required rescue analgesia. Unpaired t-test and Chi-square test was used to carry out all the data analysis. The pain intensity assessed on VAS score was significantly better for Tramadol group compared to Nefopam group at all time periods except at 15 minutes and a significant difference was present in verbal rating scale score between the groups only at 24 hours. Side effect profile and requirement of rescue analgesia were more in Nefopam hydrochloride group.Tramadol hydrochloride was more effective in providing post-operative pain relief in patients compared to Nefopam hydrochloride.
Fusion Reaction Study of some Selected Halo Systems
Authors: Abbas Shaimaa A. , Hussein Aeshah Ali , Obaid Sarah M. , Mohammed Noor Adil 
Published: September 2022

The challenge in studying fusion reaction when the projectile is neutron or proton rich halo nuclei is the coupling mechanism between the elastic and the breakup channel, therefore the motivation from the present calculations is to estimate the best coupling parameter to introduce the effect of coupled-channels for the calculations of the total cross section of the fusion , the barrier distribution of the fusion and the average angular momentum 〈L〉 for the systems 6He+206Pb, 8B+28Si, 11Be+209Bi, 17F+208Pb, 6He+238U, 8He+197Au and 15C+232Th using quantum mechanical approach. A quantum Coupled-Channel Calculations are performed using CC code. The predictions of quantum mechanical approach are comparable with the measured data that is available. Above and below the Coulomb barrier, comparison of theoretical calculations of quantum mechanical with the relevant measured data demonstrates good agreement.
Interrelationships between sex hormones, brain-derived neurotrophic factor, and cognitive impairment in male patients with schizophrenia and receiving chronic antipsychotic treatment
Authors: Li Jin , Xiao Wenhuan , Ye Fei , Tang Xiaowei , Jia Qiufang , Zhang Xiaobin 
Published: September 2022

Abstract
Background: Complex interactive effects between brain derived neurotrophic factor (BDNF) and sex hormones are known to be involved to the pathogenesis of schizophrenia (SCZ). However, the impact of these interrelationships between BDNF and sex hormones on cognitive function and clinical manifestations in chronic antipsychotic-treated male (CATM) SCZ patients have yet to be investigated. We investigated interrelationships between sex hormones, BDNF, clinical symptoms, and cognitive function, in the CATM patients with SCZ.
Methods: Serum concentrations of follicular-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P), testosterone (T), and prolactin (PRL) were compared between a group of 120 CATM patients with SCZ and a group of 120 healthy controls. Schizophrenia symptoms were measured by the Positive and Negative Syndrome Scale, cognition by the neuropsychological tests. The levels of BDNF and sex hormones were determined by enzyme linked immunosorbent assay (ELISA).
Results: Levels of T, PRL and LH were significantly higher in the patient group than in the healthy controls while E2 levels were significantly lower. Analysis also identified positive correlations between E2 levels and BDNF levels, and BDNF levels and the digital cancellation time, in the whole sample. we found significant correlations between PRL levels and negative symptoms score in CATM patients with SCZ.
Conclusions: This study provides the first comprehensive assessment of elevated levels of LH, PRL, and T, as well as reduced levels of E2, in CATM group when compared with controls. Another exciting finding in this study is that E2 levels and BDNF levels, along with BDNF levels and the DCT, were significantly and positively correlated in the combined subjects.
Enformer: Encoder-based sparse periodic self-attention time-series forecasting
Authors: Wang Na , Zhao Xianglian 
Published: September 2022

Abstract
Time-series forecasting makes reasonable prediction and planning on stock forecast, traffic flow, power consumption and extreme weather warning through the correlation characteristics of its own multi-dimensional data and time. The proposed Transformer structure in natural language processing is proved to be beneficial for establishing the global dependence between vectors, which is undoubtedly advantageous for the time prediction problem. However, the unchanged introduction of Transformer into the time-series forecasting will also bring corresponding problems, including high computing complexity, vector information redundancy. And bound by the unique processing methods of natural language processing problems, it ignores the common processing methods of time-series forecasting problems. To this end, we design a lightweight Transformer structure that breaks the cascade structure of traditional Transformer encoders-decoders, only using encoder to build the network. At the same time, the CMM (Coarse Matching Module) is proposed to construct the multi-scale output of the input sequence, so that the subsequent networks can capture the dependencies with different time granularity. The self-attention head is also redesigned, called sparse periodic attention, which pays more attention to the periodic dependence of sequence context while reducing the computational complexity. The overall change gives full play to the advantages of Transformer, making it more suitable for time series prediction. Thanks to the synergy of the above innovative work, the accuracy of the algorithm proposed in this paper is improved by 7.1% on average in the testing experiments of multiple public datasets, and the prediction time efficiency is also improved by 44.1%. It is proved that the reasonable improvement of transformer structure in time-series prediction can reduce the amount of calculation and give consideration to the accuracy at the same time.