bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dificuldades e desafios enfrentados pelos enfermeiros no pré-natal de alto risco: um estudo fenomenológico
Authors: Silva Eli Borges de Freitas , Silva Jovânia Marques de Oliveira e , Santos Jéssica Diodino da Silva , Leandro Vinícius Luiz Farias Oliveira , Comassetto Isabel , Holanda Juliana Bento de Lima , Tavares Clodis Maria , Silva Meirielly Kellya Holanda da 
Published: June 2022

Objetivo: compreender o mundo vida do enfermeiro ao enfrentar dificuldades e desafios no pré-natal de alto risco. Metodologia:estudo do tipo qualitativo de abordagem fenomenológica sendo utilizado como suporte teórico metodológico a sociologia compreensiva de Alfred Schütz. Os cenários de desenvolvimento do estudo foram os quatro ambulatórios de referência para o pré-natal de alto risco de Alagoas: Hospital Universitário Professor Alberto Antunes, em Maceió; Maternidade Escola Santa Mônica, em Maceió; Espaço Nascer, em Arapiraca; e Centro de Assistência à Saúde da Mulher Quitéria Neves, em Santana do Ipanema. Participaram do estudo, sete enfermeiras que prestam assistência às gestantes nos ambulatórios de pré-natal de alto risco de Alagoas. Foram realizadas entrevistas abertas, no local de atuação de cada uma das enfermeiras, guiadas pela seguinte questão disparadora: “Como é para você a experiência de atuar como enfermeiro assistindo gestantes que apresentam alto risco, no pré-natal? Resultados: emergiu a partir dos depoimentos, a categoria temática: mundo vida do enfermeiro enfrentando dificuldades e desafios para atuar no pré-natal de alto risco.Conclusão: os dados analisados permitiram identificar a assistência desempenhada pelas enfermeiras no cuidado às gestantes, no pré-natal de alto risco em Alagoas, através da identificação dos “motivos porque” e “motivos para” dessa ação profissional e das falas dos sujeitos, desvelando as dificuldades e desafios enfrentados por esses enfermeiros em seu mundo vida.
Determinação dos parâmetros microbiológicos, físico-químicos e parasitológico da água de bebedouros presentes em uma unidade hospitalar do Sudoeste da Bahia
Authors: Silva Rafaela Meira , Gama Vítor França Leite , Amorim Aline Teixeira , Portela Fernanda Santos , Silva Tatielle Pereira , Santos Tayanne Andrade dos 
Published: June 2022

As características da água podem ser alteradas pelos diferentes componentes presentes, capazes de influenciar os parâmetros físicos, químicos e biológicos, e determinar a qualidade. Para estar adequada ao consumo humano é imprescindível que a água seja potável e para isso, uma constante vigilância deve ser realizada, a fim de atender aos padrões de potabilidade estabelecidos. Este estudo teve como objetivo determinar os parâmetros físico-químicos e microbiológicos, bem como a análise parasitológica, das amostras da água de bebedouros de um hospital particular do sudoeste da Bahia. Os resultados obtidos foram confrontados com os parâmetros determinados pelo Ministério da Saúde (MS) com a justificativa de certificar uma água de qualidade, fornecida no ambiente hospitalar. Trata-se de um estudo de caráter descritivo-exploratório, com características que se baseiam na observação através de métodos quantitativos e qualitativos. Uma vez que, o uso desses dois métodos, possibilita resultados mais aprofundados e abrangentes da realidade em investigação, assegurando uma melhor compreensão do problema em estudo. As análises para os parâmetros físico-químicos atenderam os padrões de potabilidade estabelecidos pela Portaria 2.914/2011 e foram seguros para as análises parasitológicas. Em relação as análises microbiológicas, os desfechos se mostram insatisfatórios pois apontam a presença de coliformes em uma das amostras estudadas.
Automedicação influenciada pela mídia no Brasil
Authors: Costa Junior Vanilson Silva , Oliveira Ana Lívia Rodrigues de , Amorim Aline Teixeira 
Published: June 2022

O objetivo estimar, através de referências e artigos científicos, os impactos causados pela mídia e pelas publicidades de medicamentos, bem como esses fatores aumentam a prática de automedicação, identificando os riscos de saúde que a mesma pode ocasionar na população. O presente estudo trata-se de uma revisão de literatura integrativa, baseada a partir de um estudo bibliográfico, a qual tem como objetivo alcançar profundo entendimento de um determinado fenômeno com base em estudos anteriores. O farmacêutico desempenha um papel importante na uma oferta de medição para evitar o uso irracional de drogas, ser um especialista que pretenda prestar assistência médica, de acordo com lei e código de conduta, serviços de garantia, e acesso a medicamentos, atendimento administrativo especializado e consciência dos perigos das reações adversas, interações medicamentosas e dependência de drogas. Nesse sentido, o farmacêutico é considerado um promotor de saúde e deve fornecer informações ao usuário que escolherá o melhor produto prevenção e tratamento de doenças, principalmente quando o paciente opta a prática da automedicação. O farmacêutico também é responsável por identificar sinais e sintomas de problemas de saúde e tomar decisões, aconselhar o encaminhamento do paciente a um médico. A população é muito influenciada por anúncios de medicamentos, que produzem automedicação indiscriminadamente. Nota-se ao ver nos estudos a dificuldade dos profissionais médicos diariamente no exercício do papel de direcionar o uso efetivo de remédios, a prática da automedicação sempre foi utilizada por muito tempo, principalmente pela dificuldade de acesso da população no sistema de saúde. A publicidade destina-se a destacar o produto também como resultado do aumento de suas vendas, deixando de lado, em muitos casos, às vezes, informações sobre a segurança do medicamento, como efeitos colaterais, reações adversas e interações medicamentosas, mostrando apenas seus benefícios e indicadores.
Tendências de hospitalizações por acidente vascular cerebral no Ceará 2009-2020
Authors: Braz Antônio Igor Duarte , Araújo Samila Torquato , Pereira Maíra Barroso , Mendonça Francisco Antônio da Cruz , Rabêlo Dieison Roberto Vieira , Macêdo André Luiz Coutinho Araújo , Guimarães Manoel Pedro Guedes , Medeiros Melissa Soares 
Published: June 2022

Objetivo: Analisar a tendência de hospitalizações por acidente vascular cerebral (AVC) na população adulta no estado do Ceará, Brasil. Métodos: Estudo ecológico com desenho de séries temporais, realizado a partir de duas bases de dados secundárias, sendo elas o Sistema de Informações Hospitalares do Sistema Único de Saúde (SIH/SUS) e o Instituto Brasileiro de Geografia e Estatística (IBGE) do Ceará e suas regiões de saúde, no período de 2009 a 2020. Resultados: Do total de hospitalizações por AVC no Ceará, obteve-se uma média de 7.981,5 internações, observando aumento gradativo a partir de 2012, com ápice em 2019 (9.485/ano). Pacientes com idade entre 70 e 79 anos apresentaram maior média anual de internações (2.072,4/ano). O número absoluto de óbitos hospitalares foi de 3.277 em 2009 a 2.750 em 2020, tendo uma redução de aproximadamente 16,08%. Quanto às regiões de saúde no Ceará, foi possível observar uma tendência crescente de internações no Litoral Leste, Sertão Central e Norte. Conclusão: O Ceará apresentou uma tendência crescente de hospitalizações por AVC nos últimos 11 anos, com faixa etária predominante de 70 a 79 anos. Apesar do aumento das hospitalizações houve uma redução no número absoluto de óbitos hospitalares.
Paleoenvironmental Changes Since the Late Pleistocene Revealed by Ostracodes Record in Changmu Co., Western Tibet
Authors: Song Gao , Wang Hailei 
Published: June 2022

A 4.9-m profile (BG-1) in Changmu Co., western Tibet, provides a continuous climate record from the Late Pleistocene to mid-Holocene on the basis of ostracode assemblages and shell trace elements. The results show six distinct climate change zones from 23.4 to 4.9 ka BP based on U-Th dating. The climate remained extremely cold until 13 ka BP because of the influence of the Last Glacial Maximum, which was indicated by the rare ostracodes occurring in this period. After that, the temperature rose gradually and the paleolake (Changmu Co.) enlarged. The ostracode assemblage during this period had high abundance and diversity, although the dominance of cold-water species and low Mg/Ca ratios indicate that the climate was still cold. More runoff water from a relatively warm climate entering into the lake, suggested by the increased U/Ca and Mn/Ca, led to a high lake level of 13–10.5 ka BP; this trend was also verified by the decreasing Sr/Ca values. The climate changed from humid to drought between 10.5 and 7.9 ka BP, which was inferred from the decreased abundance of ostracodes; however, there was a short humid period from 9.5 to 9.2 ka BP suggested by increased U/Ca and Mn/Ca ratios. A gradual transition to a humid environment began at 7.9 ka BP and ended at 5.3 ka BP. After this period, an extremely arid climate occurred after rising temperature and increasing evaporation, indicated by sharply increased Mg/Ca and Sr/Ca ratios. Eventually, the Changmu Co. paleolake shrank and dried up at some time after 4.9 ka BP. The changes in paleoclimate in Changmu Co. since the Late Pleistocene corresponded well to changes that occurred in the Westerlies-dominated Central Asia, suggesting that the climate in this region was mainly controlled by Westerlies circulation.
The Effect of BMI, Age, Gender, and Pubertal Stage on Bone Turnover Markers in Chinese Children and Adolescents
Authors: Cao Bingyan , Liu Meijuan , Luo Qipeng , Wang Qiao , Liu Min , Liang Xuejun , Wu Di , Li Wenjing , Su Chang , Chen Jiajia , Gong Chunxiu 
Published: June 2022

ObjectivesTo ascertain the associations of serum bone turnover markers (BTMs) levels with body mass index (BMI) in Chinese children and adolescents, and whether the influence of BMI, age, pubertal stage on BTMs varied by gender.MethodsA total of 500 students (180 controls and 320 children and adolescents with overweight/obesity) aged 9–14 years were randomly selected from the Chinese National Survey on Students Constitution and Health Cohort. Serum levels of BTMs, including bone formation marker bone alkaline phosphatase (BAP), collagen type 1 C-terminal propeptide (CICP), and bone resorption markers C-terminal telopeptide of type-I collagen (CTX) were determined by commercial enzyme-linked immunosorbent assay kits. The associations among BMI, age, gender, pubertal stage, and BTMs were analyzed.ResultsSerum levels of CICP and CTX in overweight/obese children and adolescents were lower than those in controls (p&lt;0.05). Moreover, after subgroup analysis stratified by gender, the decreased serum CICP and CTX levels in overweight/obese children and adolescents were observed only in boys (p&lt;0.05). After adjustment of age and pubertal stage, there was a negative correlation between serum BAP and BMI in both boys and girls (p&lt;0.05). However, the correlations between serum CICP, CTX levels, and BMI were significant in boys but not in girls. Serum BAP and CICP levels were independently correlated with BMI, age, gender, and pubertal stage, while CTX levels were independently correlated with BMI, age, and gender (p&lt;0.05). BAP, CICP, and CTX levels showed a clear age, gender, and pubertal stage dependence with significantly higher values in boys (p&lt;0.05).ConclusionsOur findings support the associations between serum BTMs levels and BMI in Chinese children and adolescents, and suggest age, gender, and pubertal stage differences in this relationship that warrant future studies.
Human Leukocyte Antigen Fine-Mapping and Correlation Analysis of Han and Minority Leprosy Patients in Southern China
Authors: Li Zhuo , Wang Yirui , Fan Wencheng , Zhang Chang , Liu Hao , Zhang Ruixue , Cao Lu , Zhen Qi , Chen Weiwei , Yu Yafen , Li Bao , Mao Yiwen , Bai Yuanming , Wang Daiyue , Luo Sihan , Li Yuanyuan , Qin Qin , Ge Huiyao , Yong Liang , Hu Xia , Yu Yanxia , Sun Liangdan 
Published: June 2022

Backround: Leprosy is very prevalent in many populations around the world, which is well known that both alleles for human leukocyte antigen (HLA) as well as single nucleotide polymorphisms (SNPs) in the HLA region are common in leprosy patients. Previous studies have identified leprosy-associated susceptibility genes that explain only part of disease risk and heritability. In view of the complicated characteristics of the major histocompatibility complex (MHC) region, this study aimed to explore the development and variation of HLA in leprosy and its possible mechanism.Methods: Previous genome-wide association data were extracted from Han and minority populations in southern China for HLA fine-mapping studies. Insertion and deletion (INDEL), SNP, and copy number variation (CNV) imputation were determined by using the Thousand People Database (1KGP Phase 3 Dataset) as a reference panel. The HAN-MHC database was used to input the HLA classical alleles and amino acids in the MHC region, and further step-regression analysis was performed to analyze independent variation signals associated with leprosy.Results: The most significant locus rs75324027 (the same locus as rs602875 in the HLA-DR region) [p = 7.49E-09, OR= 0.62, 95%,CI: 0.52–0.73] in the intergene region between HLA-DQA1 and HLA-DRB1 was related with leprosy in M-S(Han leprosy patients in south China)disease. In M-SM (Leprosy patients of ethnic minorities in south China)disease, one of the most significant loci of the HLA-DQB1 gene was 6-32626438-A-T (p = 4.49E-08, OR = 0.36, 95%,CI: 0.25–0.52). Therefore, rs75324027 is a locus in M-S disease, and 6-32626438-a-T may be a new locus in M-SM disease. The interaction between 6 and 32626438-A-T and RS75324027 was analyzed, and A significant interaction relationship was found. In the optimal model, the accuracy of prediction was 0.5974, cross-validation Consistency:10, p = 0.0107.Conclusion: In conclusion, this study is the first to assess the association between HLA and leprosy susceptibility in Han and other minority populations in southern China using the Thousand Population database and the Han MHC database. In addition, our analysis validated the previously reported locus rs602875 in the HLA-DR region and for the first time identified an unreported independent locus in leprosy among ethnic minorities in southern China.
An Individual-Based Model to Quantify the Effect of Salinity on the Production of Apocyclops royi (Cyclopoida, Copepoda)
Authors: Yoshino Mizuki , Pan Yen-Ju , Souissi Sami , Dur Gaël 
Published: June 2022

In this study, an individual-based model (IBM) was established and applied to simulate the effects of salinity variations on the productivity of a promising live feed cyclopoid copepod Apocyclops royi for aquaculture applications. The model integrates the effect of salinity on the different reproductive traits and temperature on female longevity. To calibrate the model developed on the Mobidyc platform, we collected data from previous literature and conducted complementary experiments. The model outputs on total nauplii production match the experimental results. Both showed a progressive increase in nauplii production from 0 up to 21 PSU, beyond which the production decreases. There were no significant differences between the estimated nauplii production and the observed ones for most salinity conditions. We then used the model to estimate the egg and nauplii production of a population initiated with 1,000 females along a salinity gradient from 0 to 39 PSU during 20-d cultivation. Around the optimal salinity of 21 PSU, the egg and nauplii production peaked at 1.8x105 eggs and 1.39x105 nauplii, respectively. A deviation of 7 PSU from the optimal salinity range would lead to a loss of 22 to 25% in egg and nauplii production. The results indicate that implementing the IBM into a life-cycle model provides useful tool for managing the risks of salinity variation on the copepod productivity in aquaculture conditions.
Outcomes of Transferred Adult Venovenous and Venoarterial Extracorporeal Membrane Oxygenation Patients: A Single Center Experience
Authors: Zhao Yang-Chao , Zhao Xi , Fu Guo-Wei , Huang Ming-Jun , Zhao Hui , Wang Zhen-Qing , Li Xing-Xing , Li Jun 
Published: June 2022

ObjectivesExtracorporeal membrane oxygenation (ECMO) patients with or without transport both have high hospital mortality rate and there are few data on adult VA-ECMO transport patients. Hence, this study was designed to analyze factors that affect the outcomes of patients with ECMO transport.MethodsThis study retrospectively enrolled 126 ECMO patients transferred from regional hospital to the First Affiliated Hospital of Zhengzhou University by our ECMO team during June 2012 to Sept 2020. Data were calculated and analyzed.ResultsThe median distance of transportation was 141 (76–228) km, the median transport time consuming was 3 (1.3–4) h, the percentage of complications during transport was 40.5% (except for bleeding on cannula site, and no one death during transport), and the survival rate in hospital was 38.9%. Compared with survivors, the non-survivors were older and showed higher SOFA score, longer time with ECMO assisted, longer time in ICU and in hospital. However, after divided into VA-ECMO and VV-ECMO groups, the older age showed no significant difference between survivors and non-survivors groups of VA-ECMO patients. Moreover, the Cox regression survival analysis showed that higher SOFA score and lactate level indicated higher ICU mortality of VA-ECMO patients while higher SOFA score, higher lactate level, older age and lower MAP after transportation (&lt;70mmHg) indicated higher ICU mortality of VV-ECMO patients. However, there was no significant difference of comorbidities and complications in survivors and non-survivors groups of ECMO patients.ConclusionsThe transportation for ECMO patients can be feasible performed although life-threatening complications might occur. The SOFA score and the lactate level could be used to evaluate the risk of ICU mortality of transportation ECMO patients. Besides, lower MAP after transportation (&lt;70mmHg) had potential predictive value for short-term outcome of VV-ECMO patients.
A Multi-Atlas-Based [18F]9-Fluoropropyl-(+)-Dihydrotetrabenazine Positron Emission Tomography Image Segmentation Method for Parkinson’s Disease Quantification
Authors: Pan Yiwei , Liu Shuying , Zeng Yao , Ye Chenfei , Qiao Hongwen , Song Tianbing , Lv Haiyan , Chan Piu , Lu Jie , Ma Ting 
Published: June 2022

Objectives[18F]9-fluoropropyl-(+)-dihydrotetrabenazine ([18F]-FP-DTBZ) positron emission tomography (PET) provides reliable information for the diagnosis of Parkinson’s disease (PD). In this study, we proposed a multi-atlas-based [18F]-FP-DTBZ PET image segmentation method for PD quantification assessment.MethodsA total of 99 subjects from Xuanwu Hospital of Capital Medical University were included in this study, and both brain PET and magnetic resonance (MR) scans were conducted. Data from 20 subjects were used to generate atlases, based on which a multi-atlas-based [18F]-FP-DTBZ PET segmentation method was developed especially for striatum and its subregions. The proposed method was compared with the template-based method through striatal subregion parcellation performance and the standard uptake value ratio (SUVR) quantification accuracy. Discriminant analysis between healthy controls (HCs) and PD patients was further performed.ResultsSegmentation results of the multi-atlas-based method showed better consistency than the template-based method with the ground truth, yielding a dice coefficient of 0.81 over 0.73 on the full striatum. The SUVRs calculated by the multi-atlas-based method had an average interclass correlation coefficient (ICC) of 0.953 with the standardized result, whereas the template-based method only reached 0.815. The SUVRs of HCs were generally higher than that of patients with PD and showed significant differences in all of the striatal subregions (all p &lt; 0.001). The median and posterior putamen performed best in discriminating patients with PD from HCs.ConclusionThe proposed multi-atlas-based [18F]-FP-DTBZ PET image segmentation method achieved better performance than the template-based method, indicating great potential in improving accuracy and efficiency for PD diagnosis in clinical routine.
Probabilistic Decision-Making in Children With Dyslexia
Authors: Pereira Christa L. Watson , Zhou Ran , Pitt Mark A. , Myung Jay I. , Rossi P. Justin , Caverzasi Eduardo , Rah Esther , Allen Isabel E. , Mandelli Maria Luisa , Meyer Marita , Miller Zachary A. , Gorno Tempini Maria Luisa 
Published: June 2022

BackgroundNeurocognitive mechanisms underlying developmental dyslexia (dD) remain poorly characterized apart from phonological and/or visual processing deficits. Assuming such deficits, the process of learning complex tasks like reading requires the learner to make decisions (i.e., word pronunciation) based on uncertain information (e.g., aberrant phonological percepts)—a cognitive process known as probabilistic decision making, which has been linked to the striatum. We investigate (1) the relationship between dD and probabilistic decision-making and (2) the association between the volume of striatal structures and probabilistic decision-making in dD and typical readers.MethodsTwenty four children diagnosed with dD underwent a comprehensive evaluation and MRI scanning (3T). Children with dD were compared to age-matched typical readers (n = 11) on a probabilistic, risk/reward fishing task that utilized a Bayesian cognitive model with game parameters of risk propensity (γ+) and behavioral consistency (β), as well as an overall adjusted score (average number of casts, excluding forced-fail trials). Volumes of striatal structures (caudate, putamen, and nucleus accumbens) were analyzed between groups and associated with game parameters.ResultsdD was associated with greater risk propensity and decreased behavioral consistency estimates compared to typical readers. Cognitive model parameters associated with timed pseudoword reading across groups. Risk propensity related to caudate volumes, particularly in the dD group.ConclusionDecision-making processes differentiate dD, associate with the caudate, and may impact learning mechanisms. This study suggests the need for further research into domain-general probabilistic decision-making in dD, neurocognitive mechanisms, and targeted interventions in dD.
The Impact of Zinc Supplementation on Critically Ill Patients With Acute Kidney Injury: A Propensity Score Matching Analysis
Authors: Xia Wenkai , Li Chenyu , Zhao Danyang , Xu Lingyu , Kuang Meisi , Yao Xiajuan , Hu Hong 
Published: June 2022

BackgroundZinc is an essential trace element involved in multiple metabolic processes. Acute kidney injury (AKI) is associated with low plasma zinc, but outcomes with zinc supplementation in critically ill patients with AKI remain unknown. Our objective was to investigate the effectiveness of zinc supplementation in this patient population.MethodsCritically ill patients with AKI were identified from the Medical Informative Mart for Intensive Care IV database. Prosperity score matching (PSM) was applied to match patients receiving zinc treatment to those without zinc treatment. The association between zinc sulfate use and in-hospital mortality and 30-day mortality, need for renal replacement therapy (RRT), and length of stay was determined by logistic regression and Cox proportional hazards modeling.ResultsA total of 9,811 AKI patients were included in the study. PSM yielded 222 pairs of patients who received zinc treatment and those who did not. Zinc supplementation was associated with reduced in-hospital mortality (HR = 0.48 (95% CI: 0.28, 0.83) P = 0.009) and 30-day mortality (HR = 0.51 (95% CI, 0.30, 0.86) P = 0.012). In the subgroup analysis, zinc use was associated with reduced in-hospital mortality in patients with stage 1 AKI and those with sepsis.ConclusionsZinc supplementation was associated with improved survival in critically ill patients with AKI. The supplementation was especially effective in those with stage 1 AKI and sepsis. These results need to be verified in randomized controlled trials.