bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired insulin-stimulated myocardial glucose metabolic rate is associated with reduced myocardial energetic efficiency
Authors: Succurro Elena , Cicone Francesco , Papa Annalisa , Miceli Sofia , Vizza Patrizia , Fiorentino Teresa Vanessa , Perticone Maria , Sciacqua Angela , Guzzi Pietro Hiram , Veltri Pierangelo , Cascini Giuseppe Lucio , Andreozzi Francesco , Sesti Giorgio 
Published: September 2022

Abstract
Background: Alterations in myocardial mechano-energetic efficiency (MEEi), which represents the capability of the left ventricles to convert the chemical energy obtained by oxidative metabolism into mechanical work, have been associated with cardiovascular disease. Although whole-body insulin resistance has been related to impaired myocardial MEEi, it is unknown the relationship between cardiac insulin resistance and MEEi. Aim of this study was to evaluate the relationship between insulin-stimulated myocardial glucose metabolic rate (MrGlu) and myocardial MEEi in subjects having different degrees of glucose tolerance.
Methods: We evaluated insulin-stimulated myocardial MrGlu using cardiac dynamic positron emission tomography (PET) with 18F-Fluorodeoxyglucose (18F-FDG) combined with euglycemic-hyperinsulinemic clamp, and myocardial MEEi in 57 individuals without history of coronary heart disease having different degrees of glucose tolerance. The subjects were stratified into tertiles according to their myocardial MrGlu values.
Results: After adjusting for age, gender and BMI, subjects in I tertile showed a decrease in myocardial MEEi (0.31±0.05 vs 0.42±0.14 ml/sec*g, P=0.02), and an increase in myocardial oxygen consumption (MVO2) (10153±1375 vs 7816±1229 mmHg*bpm, P<0.0001) as compared with subjects in III tertile. Univariate correlations showed that insulin-stimulated myocardial MrGlu was positively correlated with MEEi and whole-body glucose disposal, and negatively correlated with waist circumference, fasting plasma glucose, HbA1c and MVO2. In a multivariate regression analysis running a model including several CV risk factors, the only variable that remained significantly associated with MEEi was myocardial MrGlu (b 0.346; P=0.01).
Conclusions: These data suggest that an impairment in insulin-stimulated myocardial glucose metabolism is an independent contributor of depressed myocardial MEEi in subjects without history of CHD.
Biofunctionalized carbon nanotubes as a smart nanomaterial immobilized on a tissue culture polystyrene plate for promoting neuronal outgrowth
Authors: Kim Hyun-Soo , Leong Kam W. , Kim Gi Jin , Shin Ueon Sang , Kim Hae-Won , Hwang Ji-Young 
Published: September 2022

Abstract

Carbon nanotubes (CNTs) offer attractive attributes that are useful in innovative biomaterial design for neuroscience research due to their nanoscale features, modifiable chemical functionalities, and tunable electrical properties. In this study, we developed a simple and cost-effective fabrication method for advanced surface-modified cell culture system by immobilizing biofunctionalized CNTs onto commercial tissue culture polystyrene plates. This active substrate was examined to understand the effects of electrical, morphological, and chemical interactions with CNT-entrapped drug, bpV as a PTEN inhibitor, on the neuronal differentiation of PC-12 cells. Compared to control, the percentage of neuronal cells stimulating neurites increased by a factor of 4.0, 7.8, and 10.0, when cultured on immobilized carboxylated CNT substrate, PEGylated CNT substrate, and PEGylated CNT substrate in the presence of 10 nM bpV, respectively. The bpV-loaded CNT substrates down-regulated the expression of PTEN and up-regulated the Akt/ERK signaling pathway, thereby providing the mechanism for the improved neuronal outgrowth. These results highlight the promise of the biofunctionalized CNTs as the electroactive and drug-releasing smart nanomaterials for promoting neuronal outgrowth and suggest their potential utility in future neural regeneration applications.
Pre-biologic screening and biologic monitoring in a tertiary dermatology department in Ireland
Authors: Howard-James Claudine , Malouf Martine Malouf , O'Brennan Eimear 
Published: September 2022

Abstract
Introduction
Biologic therapies are important treatments for dermatological conditions. They have immense therapeutic benefit, but they are not without side effects.
Aim
This audit plans to evaluate adherence to the British Association of Dermatology guidelines for biologic therapy for psoriasis.
Methods
We retrospectively identified patients attending Dermatology OPD established on biologic therapy for a diagnosis of psoriasis, hidradenitis suppurativa(HS) or necrobiosis liopoidica(NL). A chart review was carried out. Records were anonymised and analysed to identify demographics, primary diagnosis, biologic agent and associated investigations.
Results
In total, 50 patients were audited. Median age was 46 with 58% being female. Primary diagnosis was psoriasis in 82%, HS in 30% and NL in 2%. Seven patients(14%) had dual diagnoses of psoriasis and HS.
Seven biologic agents were in use in this cohort; most commonly Adalimumab(in 52%), then Ustekinumab(26%) and Etanercept(8%).
At baseline, disease severity scores were documented in 68% and 87% had a full viral screen. Vaccination status was documented in 80%. In groups eligible for national screening programmes; <37.5% were asked about participation. Of 19 women of childbearing potential, 21% were asked about pregnancy planning.
At last review, disease severity was documented in 94% and minimal response criteria met in 84%.
Conclusion
We identified areas of strengths and weakness in biologic pre-screening and monitoring. Strengths include viral screening, weaknesses include family planning discussions. We created screening and monitoring checklists which are being implemented in our tertiary Dermatology OPD. We plan to re-audit in six months, to include a larger sample size.
Two-dimensional Numerical Simulation of Suspended Sediment Transport in Lobo Reservoir(Western-central of Côte D’ivoire)
Authors: Koffi Bérenger , Sanchez Martin , Kouamé Kouadio Jean Olivier , Amemou Hilaire , Yangouliba Gnibga Issoufou , Kouassi Kouakou Lazare 
Published: September 2022

Abstract
Built to improve the water supply of the populations of the city of Daloa, the water reservoir of the Lobo River is no longer functioning properly due to sedimentation phenomena. This study aims to understand the hydro-sedimentary functioning of the reservoir for better management. Based on the river flows, bathymetric surveys, suspended solids concentrations, settling velocity, a two-dimensional modelling of the flows and sedimentation of the Lobo River reservoir was carried out using the MIKE 21FM/MT software. The simulation results indicate that the hydrodynamic model could reproduce the variation of water levels at the free surface of the reservoir. The results are very sensitive to the boundary conditions of the model but also to the initial conditions. A strong influence of the initial conditions on the long-term stability of the models was observed. It could be seen that in all cases the deposition rate tends towards a final value which only depends on the river flow. The trapping efficiency of the reservoir is between 26.7% and 80.4%. The different simulation scenarios indicate that the deposition thicknesses are between 0.02 and 48 mm and that the deposition occurs when the flow is loaded, during the rise and fall phase of the hydrograph. The old intake, the new intake and the weir are the preferred areas for sediment deposition in the Lobo reservoir.
Prophylactic endoscopic double endoloop hemostasis for large pedunculated colorectal polyps with a stalk: a single-center study (with video)
Authors: Ai Xinbo , Zhou Bin , Huang Yaoming , Lai Linmin , Wang Zhenjiang , Xu Xiaohong , Chen Yuping 
Published: September 2022

Abstract
Background and Aims: This study aimed to explore a novel prophylactic endoscopic therapy for post-polypectomy bleeding of larger colon polyps with a stalk (≥15 mm) and improve clinical outcomes. We also evaluated the feasibility and safety of prophylactic double endoloop hemostasis (PDEH) for larger colon polyps with a stalk (≥15 mm). Methods: This single-center prospective study included 16 patients with larger colon polyps with stalks (≥15 mm) between January 2020 and March 2022. The first endoloop (MAJ-254, MAJ-340; Olympus, Tokyo, Japan) was positioned at the base of the stalk, followed by conventional snare polypectomy. The second endoloop passed through the tail of the first endoloop and slowly approached the base. It was then successfully placed near the first endoloop to decrease the possibility of delayed bleeding. Results: A total of 16 enrolled patients underwent complete endoscopic resection, as confirmed by histopathology (three females, 13 males). The mean age of the patients was 49.8±13.8 years, and 10 patients had polyps in the sigmoid colon (62.5%). The mean diameter of all polyps was 25.6±9.5 mm, and the largest polyp had a diameter of 50 mm. Meanwhile, the mean width of the pedunculated polyps was 7.5±1.3 mm. Only six patients underwent cap-assisted endoscopic polypectomy (46.1%). The mean procedure time was 11.5±2.8 min with or without cap assistance. Additionally, the mean hospital stay was 1.7±0.4 days. Conclusions: PDEHwas found to be a feasible and safe technique for larger pedunculated colon polyps.
Progress on the unfair 0-1-polynomials conjecture using linear recurrences and numerical analysis
Authors: Ghidelli Luca 
Published: September 2022

Abstract
If the product of two monic polynomials with real nonnegative coefficients has all coefficients equal to 0 or 1, does it follow that all the coefficients of the two factors are also equal to 0 or 1? % Here is an equivalent formulation of this intriguing problem: is it possible to weigh unfairly a pair of dice so that the probabilities of every possible outcome (roll them and take the sum) were the same? If the two dice have six faces numbered 1 to 6, it is easy to show that the answer is no. But for general dice with finitely many faces, this is an open problem with no significant advancement since 1937. In this paper we examine, in some sense, the first infinite family of cases that cannot be treated with classical methods: the first die has three faces numbered with 0,2 and 5, while the second die is arbitrary. In other words, we examine factorizations of 0-1-polynomials with one factor equal to x5+a x2 +1 for some nonnegative a. We discover that this case may be solved (that is, necessarily a=0 or a=1) using the theory of linear recurrence sequences, computation of resultants, as well as analytic and numerical approximations.
2020
MSC Classification: Primary 12D05 , 60B15 , 60-08 , 11B39 , 13P15 , 26C10; Secondary 00A08 , 11C08 , 60A10 , 11C20 , 26A05 , 26D05 , 65H04.
WITHDRAWN: Deeply understanding delivery of Tetracycline under different morphologies of ZIF-8
Authors: Luan Tran Ba , Lam Nguyen Truong 
Published: September 2022

Abstract
Facile and biocompatible fabrication of ZIF-8 (zeolite imidazole framework) and its modifications are reported in two ways: TiO2@ZIF-8 and creating mesoporous. Adding a small amount of surfactant changes the traditional crystal morphology to mesoporous and reduces the amount of base needed compared to normal synthesis, thus minimizing environmental impact. The resulting crystals were characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), Infrared Spectroscopy meter (FTIR), and nitrogen adsorption measurements, which revealed the mesoporous and TiO2@ZIF-8 with polyhedral morphology. The examination of Tetracycline (TC) delivery was thoroughly studied on these hybrids ZIF-8. The loading and release of TC were controlled under the influence of factors such as morphology, and electrostatic force... by experiment data and estimating mechanism. For the first time, the number of molecules of TC adsorbed outer ZIF-8 surface area and inside its structure was investigated. This study demonstrates a green synthesis of mesoporous and TiO2@ZIF-8, maintaining an excellent yield and scalability, successfully applying for TC delivery study, and exposes the important effects of the porous structure on drug loading and release.
Serum Metabolomic Profiles for Human Gastric Adenocarcinoma Discrimination
Authors: Zhu Cailin , Liu Hui , Li Hongtao , Bi Weiyun , Bai Bin , Zhao Qingchuan 
Published: September 2022

Abstract
As one of the most common cancers, Gastric cancer (GC) exhibits high incidence and mortality. Recent studies have indicated that serum tumor markers can provide valuable diagnostic information for GC. In this study, we examine the clinicopathological significance of preoperative serum tumor markers and serum metabolites on gastric adenocarcinoma patients. We first perform the serum metabolic profiling of 139 gastric adenocarcinoma patients and 156 healthy controls by the Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS). Based on these chemometric results, we then identify three metabolites, namely phosphatidylcholine (PC) (34:1), palmitoyl-L-carnitine and m/z 361.234, as “potential marker metabolites”. Finally, we perform the ROC curve analysis on the three potential marker metabolites to distinguish the 12 early gastric adenocarcinoma patients from healthy controls. Our analysis has yielded an AUC of 0.973, with 91.7% on sensitivity and 93.6% on specificity at the best cut-off point. Our study has empirically shown that serum metabolomics is amenable for the minimally invasive diagnosis of human gastric adenocarcinoma.
Pengaruh Penggunaan Internet Terhadap Minat dan Perilaku Belajar Siswa
Authors: Rizalia Syarif , Sunartin Sunartin , Mansyur Mansyur 
Published: September 2022

Tujuan penelitian ini adalah mengetahui pengaruh penggunaan internet terhadap minat belajar biologi siswa, mengetahui pengaruh penggunaan internet terhadap perilaku belajar biologi siswa, dan mengetahui pengaruh penggunaan internet terhadap minat dan perilaku belajar biologi siswa. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan metode Survey (menggunakan angket). Hasil penelitian menunjukkan bahwa: 1) Penggunaan internet berpengaruh positif dan signifikan terhadap minat belajar Biologi siswa, dibuktikan dengan nilai signifikansi 0,000 0,05 sehingga H1 diterima, yang berarti terdapat pengaruh positif dan signifikan antara variabel X terhadap variabel Y1; 2) Penggunaan internet berpengaruh positif dan signifikan terhadap perilaku belajar Biologi siswa, dibuktikan dengan nilai signifikansi 0,000 0,05 sehingga H1 diterima, yang berarti terdapat pengaruh positif dan signifikan antara variabel X terhadap variabel Y2; 3) Penggunaan internet berpengaruh simultan terhadap minat dan perilaku belajar, dibuktikan dengan nilai simultan yang didapatkan dari hasil uji manova (Multivariate Analysis of Anova) dengan nilai signifikansi rata-rata berada dibawah 0,05.
The laparoscopic isolation of a splenic artery aneurysm: a case report
Authors: Odintsov N.S. , Belova Yu.K. , Vanyurkin A.G. , Kudaev Yu.A. , Neimark A.E. , Chernyavskiy M.A. 
Published: September 2022

Splenic artery aneurysm is a rather rare abnormality, and its treatment is a pressing issue due to high morbidity and mortality in case of its rupture.Our aim is to show the advantages of the laparoscopy for splenic artery aneurysms.Patient P., 81 years old, was admitted for surgical treatment of the splenic artery aneurysm. Angiography revealed the tortuosity of the splenic artery with a 28-mm distal aneurysm. Laparoscopic treatment of the aneurysm was performed using a stapler. No complications were observed during the postoperative period, so the patient was discharged on day 5.The laparoscopic treatment is a method of choice in patients with a tortuos splenic artery and a distal aneurysm to spare a spleen.
Received 20 December 2021. Revised 13 April 2022. Accepted 26 April 2022.
Informed consent: The patient’s informed consent to use the records for medical purposes is obtained.
Funding: The study did not have sponsorship.
Conflict of interest: Authors declare no conflict of interest.
Contribution of the authorsLiterature review: A.G. Vanyurkin, Yu.A. KudaevDrafting the article: N.S. Odintsov, Yu.K. BelovaCritical revision of the article: A.E. Neimark, M.A. ChernyavskiySurgical treatment: A.E. NeimarkFinal approval of the version to be published: N.S. Odintsov, Yu.K. Belova, A.G. Vanyurkin, Yu.A. Kudaev, A.E. Neimark, M.A. Chernyavskiy
Evaluation of the Mechanism of Action of Rosemary Volatile Oil in the
Treatment of Alzheimer's Disease Using Gas Chromatography -mass
Spectrometry Analysis and Network Pharmacology
Authors: Zhou Peijie , Wang Xuan , Zhao Yijun , She Xinhua , Jia Yanzhuo , Wang Wenfei , Li Jia , Luo Xiangning 
Published: September 2022

Objective:
This study aimed to investigate the active components and mechanism of action
of rosemary volatile oil for treating Alzheimer's disease (AD) using network pharmacology.

Methods:
We obtained the constituents of the rosemary volatile oil by searching Chinese herbal
systemic pharmacological databases and analytical platforms and constructed the constituent-target
networks by predicting and screening the action targets of the rosemary volatile oil constituents using
SwissTargetPrediction, metaTarFisher, and Pubchem. We obtained the AD-related targets using
the Genecards, OMIM, and DisGeNET databases and constructed the protein-protein interaction
networks (PPI) using the STRING database in Venny 2.1.0 graph to identify the cross-targets
by screening the core-acting targets. Cytoscape 3.8.2 software was used to construct a componenttarget-
pathway network to screen the potential active components of the rosemary volatile oil for
the treatment of AD and predict the mechanism of action of the rosemary volatile oil for the treatment
of AD in combination with existing pharmacological studies. We performed a gene ontology
(GO) biological process and a Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment
analysis of the targets of the rosemary volatile oil for the treatment of AD using R language and
molecular docking using Discovery Studio 4.0 software to validate their biological activities.

Results:
A network constructed using gas chromatography-mass spectrometry (GC-MS) analysis
identified 26 potentially active ingredients in the rosemary volatile oil. We retrieved a total of
10762 AD targets from Genecards and other databases. Our GO enrichment analysis yielded 39 entries
(P < 0.05), including 14 entries for biological processes, five entries for cellular composition,
and 20 entries for molecular function. A total of 14 entries (P < 0.05) were then enriched in the
KEGG pathway that primarily involved the IL-17 signaling pathway and the AGE-RAGE pathway.

Conclusion:
The active components of rosemary volatile oil had good inhibition of the inflammatory
response. This study provides a reference and guidance for the in-depth study on rosemary
volatile oil for the treatment of AD.
Computer Aided Reverse Vaccinology: A Game-changer Approach for
Vaccine Development
Authors: Srivastava Poornima , Jain Chakresh Kumar 
Published: September 2022

Abstract:
One of the most dynamic approaches in biotechnology is reverse vaccinology, which
plays a huge role in today’s developing vaccines. It has the capability of exploring and identifying
the most potent vaccine candidate in a limited period of time. The first successful novel approach
of reverse vaccinology was observed in Neisseria meningitidis serogroup B, which has revolutionised
the whole field of computational biology. In this review, we have summarized the application
of reverse vaccinology for different infectious diseases, discussed epitope prediction and various
available bioinformatic tools, and explored the advantages, limitations and necessary elements of
this approach. Some of the modifications in the reverse vaccinology approach, like pan-genome
and comparative reverse vaccinology, are also outlined. Vaccines for illnesses like AIDS and hepatitis
C have not yet been developed. Computer Aided Reverse vaccinology has the potential to be a
game-changer in this area. The use of computational tools, pipelines and advanced soft-computing
methods, such as artificial intelligence and deep learning, and exploitation of available omics data
in integration have paved the way for speedy and effective vaccine designing. Is reverse vaccinology
a viable option for developing vaccines against such infections, or is it a myth? Vaccine development
gained momentum after the spread of various infections, resulting in numerous deaths; these vaccines
are developed using the traditional technique, which includes inactivated microorganisms. As a result,
reverse vaccinology may be a far superior technique for creating an effective vaccine.
Glycation of Immunoglobulin-G from Pentose Sugar: A Cause for Structural
Perturbations
Authors: Alenazi Fahaad , Ahmad Saheem , Saleem Mohd , Syed Khaja Azharuddin Sajid , Zafar Mubashir , Alharbi Mohammed Salem , Hagbani Turki Al , Khan Mohd Yasir 
Published: September 2022

Background:
Glycation of immunoglobulin-G (IgG) molecule with monosaccharides may cause significant structural disability thus resulting in their loss of function. The accumulation of AGEs formed from glycation play an important role in the aliments associated with metabolic diseases. Therefore, excess of sugar in plasma, interferes with the functioning of IgG and may contribute to wide range of diabetes-associated complications. The long-term formation of these heterogeneous AGEs may accumulate and can affect plasma proteins, especially long-lived proteins. In this study, we analyze glycation of immunoglobulin-G (IgG) with 2’-deoxyribose (deoxyribose) instigated modification in IgG structure and AGEs formation.

Methods:
This study aims to glycate IgG from varying concentrations of a pentose sugar, 2’-deoxy-ribose (deoxyribose). Post glycation of IgG, both the native and its glycated analogue were characterized by various physicochemical methods and techniques. The glycated protein will be assessed for its stability and perturbations by UV-VIS., fluorescence and FT-IR spectroscopic techniques. Moreover, the early glycation product will be done by NBT assay and other biochemical parameters like HMF, carbonyl content and thioflavin-T assays were also performed to see the biochemical changes induced in the glycated IgG macromolecule.

Results:
Glycation of protein macromolecules generates stable early glycation products (Amadori products). Later on, these Amadori products involve in series of chemical reactions to form more stable advanced glycation end products (AGEs).Our experimental study results could validate the modification in IgG structure and AGEs formation.

Conclusion:
The formation of IgG-AGEs from glycation of IgG with deoxyribose could exert cellular toxicity and might initiates secondary complications of diabetes. Therefore, this study emphasized on glycation reaction of IgG from deoxyribose and which has not been reported yet.
Significance of Molecular Docking in Developing Potent Antimicrobial
1,3,4-Thiadiazole Derivatives
Authors: Kaur Parminder , Arora Vimal 
Published: September 2022

Abstract:
New drug development has been a convoluted, costly, tedious, and difficult job. Overall,
enormous sums of money are required for a new drug development pipeline through traditional methods.
The pharmaceutical industry faces challenges in diminishing the research cost and time period for
new drug discovery. Artificial intelligence has contributed to the industry for quicker, less expensive,
and more successful drug designs by giving new paradigms such as computer-aided drug discovery.
Recently, the fast development of computational tools for drug discovery is exhibiting remarkable effects
on drug design. This article delivers knowledge and success stories of artificial intelligence via
Computer Aided Drug Design (CADD) in Medicinal Chemistry and considers the assistance of molecular
docking in developing anti-microbial thiadiazole derivatives during the last decade.