bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cranial osteomyelitis associated with SAPHO syndrome: An underdiagnosed cause of chronic headache
Authors: Sugie Masayuki , Yasaki Shunji 
Published: March 2022

AbstractA 50‐year‐old woman having palmoplantar pustulosis was admitted with a headache accompanied by occipital bulge. She had a history of cryptogenic cervical spondylitis which had not completely remitted despite treatment with nonsteroidal anti‐inflammatory drugs. Head magnetic resonance imaging revealed enhanced swelling in the soft tissues of the right occipital region corresponding to the bulging locus. Bone scintigraphy demonstrated increased uptake in the parieto‐occipital bone, cervical spine, and sternoclavicular joints. Considering the negative results of the culture tests, she was diagnosed with aseptic cranial osteomyelitis induced by synovitis‐acne‐pustulosis‐hyperostosis‐osteitis (SAPHO) syndrome; cervical osteitis might induce her unidentified spondylitis. This syndrome is unrecognized as a cause of secondary headache. Based on our review of previous reports and the current case, we suggest that a painful bulge, which is demonstrated as an enhanced swelling in the cephalic soft tissue, may be a diagnostic cue for SAPHO syndrome.
Women's Low Employment Rates in India: Cultural and Structural Explanations
Authors: Chatterjee Esha , Vanneman Reeve D. 
Published: March 2022

AbstractIndian women's labor force participation rates have long demonstrated a U‐shaped relationship with their education, rather than a more conventional positive linear relationship. The low rates of employment for moderately educated women are usually explained either as a result of the cultural stigma of women's employment in a patriarchal society or because of the lack of demand from white‐collar and light manufacturing jobs for women with middle levels of education. Using especially well‐suited data from two waves of the India Human Development Survey, we test these explanations by examining the education–employment relationship in districts with low cultural stigma (low observance of purdah) and high proportions of (salaried) employment considered “suitable” for women. We find little support for either the cultural or structural explanations: the education–employment relationship remains U‐shaped in districts with low stigma or with more “suitable” salaried employment. Instead, we suggest a better explanation lies in the high levels of gender segregation where most white‐collar jobs are reserved for men. We simulate what the education–employment relationship would look like if these white‐collar occupations were female‐dominated as they are in most places in the world and find a more conventional linear relationship.
Sovereign bail‐outs and fiscal rules in a banking union*
Authors: Marattin Luigi , Meraglia Simone , Minetti Raoul 
Published: March 2022

AbstractIn this paper, we study optimal fiscal rules in a two‐country economy in which cross‐country linkages between sovereign debts and banking sectors motivate bail‐outs among countries. The first‐best sovereign borrowing, which is contingent on the output gap between the countries, cannot be achieved in the presence of asymmetric information on a country's potential output. Because bail‐out induces overborrowing, fiscal rules can be implemented to prevent the ensuing inefficiency. A mechanism can be designed to induce a country with low potential output (i.e., a small negative output gap) to run an optimal budget deficit upon receiving a transfer (ex post) from the other country. We characterize conditions under which this fiscal mechanism Pareto dominates a “cyclically adjusted” fiscal rule imposing a unique ceiling on a country's borrowing, independently of its potential output. We apply our setting to a discussion of the implications for fiscal rules within the European Monetary Union.
Muscular heat shock protein response and muscle damage after semi‐professional football match
Authors: Wiig Håvard , Cumming Kristoffer T. , Handegaard Vilde , Stabell Jostein , Spencer Matthew , Raastad Truls 
Published: March 2022

PurposeA typical football match leads to neuromuscular fatigue and physical performance impairments up to 72–96 h post‐match. While muscle damage is thought to be a major factor, damage on the ultrastructural level has never been documented. The purpose of this study was to investigate post‐match cellular muscle damage by quantifying the heat shock protein (HSP) response as a proxy for protein damage.MethodsMuscle biopsies, blood samples, countermovement jumps, and perception of muscle soreness were obtained from twelve semi‐professional football players 1, 24, 48, and 72 h after a 90‐min football match. Muscle biopsies were analyzed for αB‐crystallin and HSP70 in the cytosolic and cytoskeletal sub‐cellular fractions by Western blotting. Fiber type‐specific αB‐crystallin and HSP70 staining intensity, and tenascin‐C immunoreactivity were analyzed with immunohistochemistry. Blood samples were analyzed for creatine kinase and myoglobin.ResultsWithin 24 h post‐match, a 2.7‐ and 9.9‐fold increase in creatine kinase and myoglobin were observed, countermovement jump performance decreased by −9.7% and muscle soreness increased by 0.68 units. αB‐crystallin and HSP70 accumulated in cytoskeletal structures evident by a 3.6‐ and 1.8‐fold increase in the cytoskeletal fraction and a parallel decrease in the cytosolic fraction. In type I and II fibers, αB‐crystallin staining intensity increased by 15%–41% and remained elevated at 72 h post‐match. Lastly, the percentage of fibers with granular staining of αB‐crystallin increased 2.2‐fold.ConclusionsFootball match play induced a muscular HSP stress response 1–72 h post‐match. Specifically, the accumulation of HSPs in cytoskeletal structures and the granular staining of αB‐crystallin suggests occurrence of ultrastructural damage. The damage, indicated by the HSP response, might be one reason for the typically 72 h decrease in force‐generating capacity after football matches.
Time spent walking and disability‐free survival in older Japanese: The Ohsaki Cohort 2006 Study
Authors: Ito Kumiko , Tomata Yasutake , Obuchi Shuichi , Kawai Hisashi , Zhang Shu , Sone Toshimasa , Sugawara Yumi , Tsuji Ichiro 
Published: March 2022

The extent to which long disability‐free survival (DFS) time can be extended according to the amount of time spent walking has not been investigated. The aim of this study was to examine the association between time spent walking per day and DFS time in older adults. We conducted a cohort study of 14 342 disability‐free individuals (aged ≥ 65 years) living in Ohsaki City, Japan. The amount of time spent walking per day (<0.5 h, 0.5–1 h, ≥1 h) by each individual in 2006 was assessed by a self‐reported questionnaire. Data on 11‐year incident functional disability were retrieved from the public Long‐Term Care Insurance database. After estimating the multivariable‐adjusted hazard ratios (HRs) of the composite outcome (incident functional disability or death), the multivariable‐adjusted 50th percentile differences (50th PDs; difference in the period until the first 50% of the composite outcome occurred) were estimated according to time spent walking. Among 114 764 person‐years, the composite outcome occurred in 7761 persons (67.6 per 1000 person‐years). The HRs (95% confidence intervals) of the composite outcome were 1.00 (reference) for <0.5 h, 0.84 (0.79, 0.88) for 0.5–1 h, and 0.78 (0.74, 0.83) for ≥1 h (p‐trend < 0.001). The 50th PDs (95% confidence intervals) of DFS time were 238 (155, 322) days longer for 0.5–1 h and 360 (265, 454) days longer for ≥1 h, in comparison with <0.5 h. The results suggest that longer time spent walking per day contributes to longer DFS time.
Fifty years of welfare state generosity
Authors: Scruggs Lyle A. , Ramalho Tafoya Gabriela 
Published: March 2022

AbstractThis article describes an overview of key findings from the Comparative Welfare Entitlements Project (CWEP). CWEP compiles major features of the generosity of unemployment, sickness and public pension programs over the last several decades in 21 countries. Describing and extending earlier work to measure the institutional variation in major social insurance programs over time, we provide previously unpublished methodological details of widely used measures of program generosity; measures which have appeared in over 200 analyses during the last decade and a half. We find a high level of variation in wage replacement and benefit conditionality across programs in most countries; calling into question the notion of an historically stable configurations of characteristics, at least during the last 45 years. For instance, our research shows that several prototypical social democratic welfare states experienced the highest declines in generosity in the last three decades. Furthermore, we also show that, as late as the mid‐1970s, some ‘social democratic’ welfare states still trailed some ‘conservative’ welfare states, including prototypical ones like Germany.
Association between gut colonization of vancomycin‐resistant enterococci and liver transplant outcomes
Authors: Chiang Diana , Dingle Tanis C. , Belga Sara , Kabbani Dima , Bhanji Rahima A. , Walter Jens , Abraldes Juan G. , Cervera Carlos 
Published: March 2022

AbstractBackgroundVancomycin‐resistant enterococci (VRE) colonization is common in liver transplant recipients and has been associated with worse posttransplant outcomes.MethodsWe conducted a retrospective cohort study at the University of Alberta Hospital including patients who underwent a liver transplant between September 2014 and December 2017.ResultsOf 343 patients, 68 (19.8%) had pretransplant VRE colonization and 27 (27/275, 9.8%) acquired VRE posttransplant, 67% were males and the median age was 56.5 years. VRE colonized patients at baseline had higher MELD scores and required longer posttransplant hospitalization. VRE colonization was associated with increased risk of early acute kidney injury (AKI) (64% vs. 52%, p = .044), clinically significant bacterial/fungal infection (29% vs. 17%, p = .012) and invasive VRE infection (5% vs. 1%, p = .017). Mortality at 2 years was 13% in VRE‐colonized versus 7% in noncolonized (p = .085). On multivariate analysis, VRE colonization increased the risk of posttransplant AKI (HR 1.504, 95% CI: 1.077‐2.100, p = .017) and clinically significant bacterial or fungal infection at 6 months (HR 2.038, 95% CI: 1.222–3.399, p = .006), and was associated with nonsignificant trend toward increased risk of mortality at 2 years posttransplant (HR 1.974 95% CI 0.890–4.378; p = .094).
imageConclusionsVRE colonization in liver transplant patients is associated with increased risk of early AKI, clinically significant infections, and a trend toward increased mortality at 2 years.
AtGH3.10 is another jasmonic acid‐amido synthetase in Arabidopsis thaliana
Authors: Delfin Jay C. , Kanno Yuri , Seo Mitsunori , Kitaoka Naoki , Matsuura Hideyuki , Tohge Takayuki , Shimizu Takafumi 
Published: March 2022

SUMMARYJasmonoyl‐isoleucine (JA‐Ile) is a key signaling molecule that activates jasmonate‐regulated flower development and the wound stress response. For years, JASMONATE RESISTANT1 (JAR1) has been the sole jasmonoyl‐amino acid synthetase known to conjugate jasmonic acid (JA) to isoleucine, and the source of persisting JA‐Ile in jar1 knockout mutants has remained elusive until now. Here we demonstrate through recombinant enzyme assays and loss‐of‐function mutant analyses that AtGH3.10 functions as a JA‐amido synthetase. Recombinant AtGH3.10 could conjugate JA to isoleucine, alanine, leucine, methionine, and valine. The JA‐Ile accumulation in the gh3.10–2 jar1‐11 double mutant was nearly eliminated in the leaves and flower buds while its catabolism derivative 12OH‐JA‐Ile was undetected in the flower buds and unwounded leaves. Residual levels of JA‐Ile, JA‐Ala, and JA‐Val were nonetheless detected in gh3.10–2 jar1‐11, suggesting the activities of similar promiscuous enzymes. Upon wounding, the accumulation of JA‐Ile and 12OH‐JA‐Ile and the expression of JA‐responsive genes OXOPHYTODIENOIC ACID REDUCTASE3 and JASMONATE ZIM‐DOMAIN1 observed in WT, gh3.10–1, and jar1‐11 leaves were effectively abolished in gh3.10–2 jar1‐11. Additionally, an increased proportion of undeveloped siliques associated with retarded stamen development was observed in gh3.10–2 jar1‐11. These findings conclusively show that AtGH3.10 contributes to JA‐amino acid biosynthesis and functions partially redundantly with AtJAR1 in sustaining flower development and the wound stress response in Arabidopsis.
TonoVet Plus®: Higher reliability and repeatability compared with Tono‐Pen XL™ and TonoVet® in rabbits
Authors: Barbosa Sirlene F. , Raposo Ana Claudia S. , Dórea Neto Francisco de Assis , Araujo Nayone L. L. C. , Oliveira Maria Madalena S. , Oriá Arianne P. 
Published: March 2022

AbstractObjectiveTo evaluate the accuracy and repeatability of the Tono‐Pen XL™, TonoVet® and TonoVet Plus® tonometers by manometric evaluation, and to establish adjustment equations for intraocular pressure (IOP) estimates in rabbits.Animal StudiedRabbits.ProceduresA postmortem study was conducted on seven rabbit eyes to verify the correlation between manometry and tonometry with an artificial incremental increase in IOP from 5 and 60 mmHg. A clinical study was conducted to evaluate accuracy and to establish reference values for the species, with measurement of IOP in 17 animals, for 2 consecutive days, with the same tonometers and calibrations used in the postmortem evaluations.ResultsThere were strong linear trends for all evaluated tonometers. In the in‐vivo evaluation, the mean IOP values were: 14.23 ± 1.75 (Tono‐Pen XL™); 13.89 ± 2.07 (TonoVet® calibration mode ‘d’); 8.88 ± 1.24 (TonoVet calibration mode ‘p’); 18.59 ± 1.94 (Tonovet Plus®). There was a significant difference in the two evaluation times for the two TonoVet® calibration modes. The adjustment equations generated from the manometry for the evaluated tonometers were: Y = 0.2570X + 2.219 (Tono‐Pen XL™), Y = 0.2289X + 2.389 (TonoVet® ‘d’), Y = 0.4043X + 4.062 (TonoVet® ‘p’), Y = 0.1233X + 0.3644 (TonoVet Plus®) (X is device‐estimated IOP).ConclusionsAll evaluated tonometers were well correlated with the manometry, with an underestimation of IOP by all devices. Applying adjustment formulas may compensate for systematic errors. TonoVet Plus® was well tolerated, and showed better repeatability and reliability in successive evaluations.
Distribution and phylogenetics of hepatitis E virus genotype 4 in humans and animals
Authors: Li Bingzhe , Wagner Abram L. , Song Yujian , Chen Xiangxiang , Lu Yihan 
Published: March 2022

AbstractBackgroundWorldwide, hepatitis E virus (HEV) infection is considered a significant public health concern. In particular, HEV genotype 4 (HEV‐4) has spread to more areas and host species. In this study, we describe the global distribution of HEV‐4 and characterize HEV‐4 subtypes by host, country and year of isolation.MethodsWe retrospectively collected HEV‐4 sequences available before December 31, 2019, in GenBank. HEV‐4 and its subtypes were determined using phylogenetic comparison with HEV reference sequences. Information on the isolation of the sequences was extracted from the GenBank or original publications. Temporal, spatial and host characteristics of the sequences were summarized and nucleotide similarity was calculated based on five amplified fragments within HEV genome, stratified by host, country and year.ResultsA total of 2295 HEV‐4 complete and partial nucleotide sequences were studied. The majority (92.7%) was isolated in China's mainland, Japan, Hong Kong and France. A total of 20 animal hosts were documented, though swine remained predominant (71.7%). Globally, prevalent HEV‐4 subtypes changed remarkably over the last 18 years. Subtypes 4a, 4b, 4d and 4h were most commonly isolated (80.3%). Subtypes 4c, 4e, 4f, 4g and 4i remained limited in temporal distribution. High nucleotide similarities were observed between the sequences amplified in HEV ORF2, in the same and neighbouring countries, and in similar animal hosts.ConclusionChina and Japan are endemic for HEV‐4, and have all the subtypes. In Europe, France has a high prevalence of HEV‐4. Increases in affected areas and animal hosts imply consistent cross‐border and cross‐species transmission.
Reorientation of Free-Falling Legged Robots
Authors: Charlet Mark , Gosselin Clément 
Published: March 2022

Abstract
Based on the cat-righting reflex, this paper presents two reorientation maneuvers for legged robots that can produce roll and pitch reorientation during free fall. In order to better describe and plan these maneuvers, two separate, but equivalent, theoretical frameworks that describe the kinematic and dynamic behavior of free-floating articulated architectures are explored and developed. A nine-degree-of-freedom quadruped robot architecture is then presented and used to demonstrate the proposed maneuvers. Finally, kinematic and dynamic simulations of this architecture are performed. The results validate the presented theoretical framework and demonstrate that both roll and pitch reorientations are obtained through the application of the presented maneuvers.
Integrating ecological and molecular data to investigate species maintenance and interspecific hybridization between the redbreast sunfish (Lepomis auritus) and the pumpkinseed sunfish (Lepomis gibbosus)
Authors: Flamio Richard , Levano Samantha R. , Kashiwagi Tom , Makkay Amanda M. , Hekkala Evon R. 
Published: March 2022

True sunfishes (genus Lepomis Rafinesque, 1819) of North America are renowned for hybridization, although hybrids often comprise only a fraction of the sunfish population in natural systems. Species boundaries may be maintained through premating mechanisms (e.g., ethological and habitat isolation), which may be facilitated by the promiscuous sunfish mating system; primarily, singular males guard nests that multiple females visit. Natural hybridization occurs between redbreast ( Lepomis auritus (Linnaeus, 1758)) and pumpkinseed ( Lepomis gibbosus (Linnaeus, 1758)) sunfishes, but there is no published research on its extent and causes. In this study, we assessed the relationship between ecological variables and the prevalence of hybridization in a sunfish population in a freshwater lake. Nests of both species were evaluated for differences in substrate, date, water depth, temperature, and dissolved oxygen. Sequencing of one fragment of nuclear DNA (calmodulin intron 4) and one fragment of mitochondrial DNA (12S) was employed on adult males and eight offspring from each nest to determine genetic identity and hybridization direction. Nonparametric tests found a significant difference in substrate between species’ nests ( p < 0.01), warranting further investigation into nest substrate as a mechanism for species maintenance. Furthermore, we observed asymmetrical hybridization with the less abundant species (redbreast sunfish) disproportionately affected.
College English Teaching Quality Monitoring and Intelligent Analysis Based on Internet of Things Technology
Authors: Wang Xin 
Published: March 2022

With the continuous development of network communication, modern control, information perception, artificial intelligence, and other technologies, the Internet of Things technology has also been more comprehensively developed and grown, and it is playing an increasingly important role in various fields of production and life. Due to the low efficiency and cumbersome procedures of the existing college English teaching quality assessment, this study intends to propose a new method to deal with this problem. Through this research, we get the following: (1) use static weight equalization method, dynamic weight adaptation method, and iterative weight method to filter and analyze the original data received by mobile phones and discard some obviously wrong values in the preprocessing. Analyzing the number requirements of the game model, the supply operation reference model, and the IoT technology upgrade model for the number of demand points, the results show that the IoT technology upgrade model requires the least number of demand points. (2) Optimize the related parameter information of the IoT system model, including candidate numbers, number of students in class, adjustment coefficient, Di, turnover rate, system cost, and total system consumption. The Internet of Things technology upgrade model performed best.

Adjustment

coefficient
=
−
102

;

Di
=
−
99.6

;

turnover
=
−
100

;

system

cost
=
−
123.2

;

SL
=
−
123.5

;

SP
=
−
99.8

. (3) Passed the test of the number of questions and feedback rate, classroom number, classroom test scores, new vocabulary number, system scoring, and comprehensive scoring to judge the model. It is found that the number of questions, feedback rate, class number, and class test scores, number of new vocabularies, system scores, and comprehensive scores of the upgraded and transformed models of the Internet of Things are above the standard values, indicating that the model is highly efficient and intelligent.
Sprachmittlung – Mediation: Welche Konsequenzen für die Praxis aus dem Companion Volume? Eine curriculumanalytische Untersuchung und theoretisch-konzeptionelle Modellierungen für den Fremdsprachenunterricht
Authors: Reimann Daniel 
Published: March 2022

Der Beitrag hat zum Ziel, in die Modellierung der Mediation im Companion Volume (Europarat 2018) zum Gemeinsamen europäischen Referenzrahmen für Sprachen/GeR (Europarat 2001) einzuführen und ihr Potential für die Praxis des Fremdsprachenunterrichts zu untersuchen. In seinem curriculumanalytischen Teil setzt sich der Aufsatz mit der Konzeption von Mediation im GeR und seiner Überarbeitung im Companion Volume auseinander. Er untersucht diese – mit Fokus auf die Neuerungen des Companion Volume – vor der Folie des Konstrukts der Sprachmittlung, das in den letzten beiden Jahrzehnten in der deutschen Bildungspolitik und Fremdsprachendidaktik entwickelt wurde. Im Anschluss daran untersucht der Beitrag, welche Anregungen für die Weiterentwicklung der Mediation im Fremdsprachenunterricht aus dem Companion Volume hervorgehen und identifiziert dafür drei Kategorien. Schließlich werden prototypische Beispiele für den Fremdsprachenunterricht und zwei konkrete Praxisbeispiele für Deutsch als Fremdsprache in Brasilien vor allem für die erste Kategorie, „Aktivitäten, die gängige Praxis im Fremdsprachenunterricht waren oder sind, aber nunmehr unter den Vorzeichen der „Mediation“ neu reflektiert werden könnten“, gegeben.
Evaluación de un circuito de apoyo a profesionales sanitarios confinados por COVID-19
Authors: García-Sierra Rosa , Moreno-Gabriel Eduard , Perich Esther Badia , Cintas Victòria Sabaté , Simó Josep M. Bonet , Violán Concepción Fors , Gil Nuria Prat , Rodríguez Mònica Piña , Torán-Monserrat Pere 
Published: March 2022

OBJETIVOS: Evaluar la implementación de un circuito telefónico de apoyo a profesionales sanitarios confinados por COVID-19 en una dirección de Atención Primaria de Barcelona, en España.
MÉTODOS: Estudio observacional, descriptivo y transversal, realizado con profesionales confinados en domicilio entre el 11 de marzo y el 31 de mayo de 2020. Se envió por correo electrónico un cuestionario con 18 preguntas cerradas y una abierta. Se realizó un análisis descriptivo de las respuestas cerradas y un análisis del contenido temático de la pregunta abierta.
RESULTADOS: 398 profesionales puntuaron globalmente el circuito con 6,54 en una escala de 1 a 10. El formato de las llamadas realizadas en el circuito de apoyo se estimó con las puntuaciones máximas, la unidad de apoyo psicológico y la coordinación por diferentes colectivos se evaluaron con las puntuaciones más bajas. El análisis del contenido de la pregunta abierta ofrece argumentos explicativos de los resultados cuantitativos.
CONCLUSIONES: El estudio permitió evaluar de manera válida y fiable la implementación de un circuito de apoyo a profesionales confinados, además de reconocer áreas de mejora.