bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical effectiveness of a combination of oxiracetam and traditional Chinese medicine rehabilitation program in the treatment of early stroke patients with hemiplegia
Authors: Zhang Xiangli , Mao Haiyu 
Published: August 2022

Purpose: To evaluate the efficacy of a combination of oxiracetam and traditional Chinese medicine rehabilitation program on early stroke patients with hemiplegia.
Methods: 120 patients with early stroke hemiplegia admitted to Wuhu Fifth People's Hospital from March 2019 to July 2020 were recruited. They were equally and randomly assigned to either a control group or a study group, using the random number table method. The control group received oxiracetam, while the study group received oxiracetam plus a traditional Chinese medicine (TCM) rehabilitation program. Outcome measures included treatment effectiveness, motor function, neurological function, TCM symptom scores, and patient satisfaction.
Results: There was significantly higher treatment effectiveness in the study group versus the control group (p < 0.05). The Fugl-Meyer score of the control group was lower than that of the study group (52.49 ± 4.73 vs 74.73 ± 5.92; p < 0.001). After treatment, patients in the study group showed lower neurological function and TCM scores than those in the control group (p < 0.05). Furthermore, the study group showed higher satisfaction than the control group (p < 0.05). Conclusion: The combination of oxiracetam and TCM rehabilitation program produce good treatment effectiveness in early stroke hemiplegia patients, and also boosts motor and neurological functions when compared to the use of oxiracetam alone. However, the combination treatment should be subjected to further clinical trials prior to application in clinical practice.
Keywords: Chinese medicine rehabilitation program; Early stroke hemiplegia; Oxiracetam; Motor function; Nerve function
Effects of SOCS3 on the development of colon cancer via regulation of HIF-1α
Authors: Chen Fang , Long Yifan , Guo Cuiyun , Zou Hui , Wang Yingying , Dong Kunbo 
Published: August 2022

Purpose: To investigate the influence of suppressor of cytokine signaling 3 (SOCS3) on rats with colon cancer (CC).
Methods: Sprague-Dawley (SD) rats were randomly divided into CC group and control group, and then CC rat model was constructed. The expression of SOCS3 in CC tissues was determined by quantitative real time-polymerase chain reaction (qRT-PCR). Hematoxylin-eosin staining (H&E) was used to examine colon tissue morphology. Immunohistochemistry (IHC) staining assay was performed to determine the expression of SOCS3 protein in colon tissues. The contents of HIF-1α, phosphorylated phosphatidylinositol 3-hydroxy kinase (p-PI3K), and phosphorylated protein kinase B (p-AKT) proteins were determined by Western blotting (WB).
Results: Compared with that in the control group, the number of tumors in CC group was significantly increased (p < 0.05). 2). On the other hand, protein and message ribonucleic acid (mRNA) expressions of SOCS3 were down-regulated in CC group (p < 0.05). 3), while protein expressions of p-PI3K, p-AKT and HIF-1α were raised in CC group (p < 0.05).
Conclusion: SOCS3 is lowly expressed in CC rats, and promotes the expression of HIF-1α by activating PI3K/AKT signaling pathway. Thus, SOCS3 provides a therapeutic strategy for the management of colon cancer.
Keywords: Colon cancer; Suppressor of cytokine signaling protein 3 (SOCS3); Hypoxia inducible factor-1α
Synergetic effect of poly (ADP-ribosyl) polymerase (PARP) inhibitor and cisplatin on ovarian cancer
Authors: Li Yanyi , Shan Ying , Duan Yingchun , Jiang Cui , A Jisaihan , Ohno Yuko 
Published: August 2022

Purpose: To investigate the effect of the combination of poly (ADP-ribosyl) polymerase (PARP) inhibitor, talazoparib (BMN673), and cisplatin on the proliferation and apoptosis of ovarian cancer cells in vitro, and on xenograft tumors of ovarian cancer cells in vivo.
Methods: Cell viability was determined by CCK-8 assay, while cell proliferation and cell cycle were assessed using colony formation assay and flow cytometry, respectively. Cell apoptosis was evaluated by flow cytometry and TUNEL assays. Western blot assay was used to measure the expression levels of proliferation- and apoptosis-related proteins.
Results: The PARP inhibitor, BMN673, produced a dose-dependent synergistic effect with cisplatin (p < 0.05). Compared with when cisplatin or BMN673 was used alone, the combination of cisplatin and BMN673 significantly inhibited the growth of transplanted tumors (p < 0.05). Immunohistochemical analysis showed that cisplatin and BMN673 treatment increased the number of cells positive for TUNEL, but reduced the population of cells positive for Ki67.
Conclusion: Thus, BMN673 and cisplatin are synergistic against ovarian cancer cells, and therefore, should be subjected to further investigations, including clinical trials, to determine the potentials of the combination for the management of ovarian carcinoma.
Keywords: PARP inhibitor; Ovarian cancer; Xenografted tumor; Cisplatin
Dexmedetomidine protects gastric mucosal epithelial cells against ischemia/reperfusion-induced apoptosis by inhibiting HMGB1-mediated inflammation and oxidative stress
Authors: Liu Tianpin , Wang Bing , Han Qiong , Gong Wansheng , Ye Juan 
Published: August 2022

Purpose: To investigate the role of dexmedetomidine in gastric ischemia/reperfusion injury using gastric mucosal epithelial cell (GES-1) model.
Methods: GES-1 were subjected to oxygen-glucose deprivation conditions, followed by increasing dexmedetomidine concentrations (0.5, 1.0, or 1.5 μM) for 4 h of reoxygenation. Cell viability and apoptosis were determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide and flow cytometry, respectively. Oxidative stress and inflammation were analyzed by enzyme-linked immunosorbent assay (ELISA).
Results: Oxygen-glucose deprivation conditions induced cytotoxicity in GES-1 by decreasing cell viability and increasing apoptosis. Dexmedetomidine treatment significantly increased the cell viability of hypoxia/reoxygenation-induced GES-1 (p < 0.01) but reduced apoptosis. Dexmedetomidine also attenuated the hypoxia/reoxygenation-induced increase in malondialdehyde and myeloperoxidase, but the decrease in superoxide dismutase and glutathione in GES-1. Moreover, upregulated tumor necrosis factor-α, interleukin (IL)-1β, and IL-18 in hypoxia/reoxygenation-induced GES-1 was downregulated by dexmedetomidine treatment. Dexmedetomidine also enhanced IL-10 levels and inhibited proinflammatory factor production (p < 0.01). High-mobility group box 1 (HMGB1) protein in GES-1 was upregulated by hypoxia/reoxygenation but decreased by dexmedetomidine. HMGB1 over-expression attenuated the dexmedetomidine-induced increase in cell viability and the decrease in apoptosis, oxidative stress, and inflammation in hypoxia/reoxygenation-induced GES-1 (p < 0.01).
Conclusion: Dexmedetomidine protects GES-1 against ischemia/reperfusion-induced apoptosis, inflammation, and oxidative stress by inhibiting HMGB1, thus providing a potential strategy for treating gastric ischemia/reperfusion injury.
Keywords: Dexmedetomidine; gastric mucosal epithelial cells; Ischemia/reperfusion; Apoptosis; Inflammation; Oxidative stress; High-mobility group box 1 (HMGB1)
The Factor of Knowledge Implementation and the Development Status of Sub-Saharan African Countries
Authors: Situma Joseph , Mutsotso Beneah M. 
Published: August 2022

Sub-Saharan African (SSA) countries have generally remained relatively poor for many decades, despite various internal and external measures. Every year, African governments conceive and implement poverty reduction and eradication policies, and multi-lateral agencies and developed countries provide development assistance to enable SSA countries achieve their development goals. This article utilises systems theory to advance the thesis that sub-Saharan countries’ failure to develop is, to a significant extent, a consequence of poor knowledge utilisation. The significance of knowledge utilisation arises from the fact that in modern society, differentiation is pronounced and each sphere requires special knowledge for optimal outcomes. However, in sub-Saharan countries, knowledge is largely utilised to secure the vulgar goals of the political elite. When knowledge is perceived to require policies that are in disharmony with those goals, it is not utilised. This paper demonstrates that the selective under-utilisation of knowledge accounts for the failure of sub-Saharan countries to realise their development goals. The analysis concludes that while in his Social Systems Niklas Luhmann conceived society to be a constituent of systems and sub-systems that work to enable it to maintain and renew itself, in SSA countries dysfunctional political systems impede the process of self-maintenance and self-renewal. As such, Sub-Saharan states must re-orient to utilise knowledge correctly.

Keywords
Knowledge, modern society, differentiation, political elite, development
Abundance, spatial distribution and threats to Indo-Pacific bottlenose dolphins (Tursiops aduncus) in an Important Marine Mammal Area in Tanzania
Authors: Kasuga Magreth P. , Varisanga Modest D. , Davenport Tim R.B. , Jiddawi Narriman , Braulik Gill T. 
Published: August 2022

Abundance estimates of cetaceans in the western Indian Ocean are rare, but important, as many cetacean populations are under threat, especially those in coastal habitats. This study aimed to generate first estimates of abundance for Indo-Pacific bottlenose dolphins (Tursiops aduncus), assessed as Near Threatened on the IUCN Red List, in an area identified by the Marine Mammal Protected Area Task Force as an ‘Important Marine Mammal Area’. Two study sites were surveyed along the east and west coastlines of the Pemba Channel, Tanzania. In west Pemba, between 2014 and 2016 four boat-based visual surveys conducted a total of 2467 km of survey effort sighting a total of 16 groups of T. aduncus. Abundance was estimated using mark-recapture models of photo-identified individuals as 83 animals (CV 7.8%, 95% CI 72-97) in the 1084km2 study area. In the Tanga study area in 2016 two boat-based visual surveys covered 1254 km of effort during which 15 groups of T. aduncus were sighted, resulting in a photo-ID based mark-recapture abundance estimate of 196 (CV 8.9%, 95% CI 165-233) individuals in the 1562 km2 study site. Group encounter rate for this species in Tanga was double that recorded in the Pemba study site. A total of 23% of identified dolphins bore the scars of interactions with fishing gear.
The Use of Language Function in Maybelline New York Cosmetic Advertisements
Authors: Septiana Ayu Kartika 
Published: August 2022

This article discusses the use of language function in Maybelline New York Cosmetic advertisements. The theory which was applied inanalysing the data and used as the main theory is taken from the book proposed by Roman Jakobson entitled The Framework of Language published in 1980. The data were taken from the advertisements of Maybelline New York Cosmeticaround 2015 until 2019 which was downloaded from YouTube. The analyse method that is used in this paper is descriptive qualitative method. Based on the result of the analysis, there are five from six kinds of language function found in Maybelline New York cosmetic advertisements, they are referential, emotive, conative, phatic, and poetic function but there’s no metalingual function.
Barriers to telepsychiatry in the geriatric Asian American population during COVID-19
Authors: Wang Jami , Kato Brian , Agustines Davin A. 
Published: August 2022

Due to the increase in anti-Asian discrimination during COVID-19, there has been a decline in mental health in the Asian community, particularly in the geriatric population. Although the current literature tends to focus on the underutilization of telemedicine in the Asian American population due to cultural barriers, our research found that the barrier to access heavily contributed to this inequity. In this study, we discuss the limited language options for the geriatric Asian American population on a few large telepsychiatry platforms, including “Teladoc and BetterHelp”, during COVID-19.
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Pendidikan Masa Pandemi Covid-19: Strategi, Adaptasi dan Transformasi
Authors: Shofan Moh. 
Published: August 2022

Artikel-artikel dalam jurnal ini mencoba untuk melihat fenomena wajah pendidikan yang berubah drastis akibat pandemi covid-19. Selama ini guru lebih cenderung mengajar dengan bertatap muka, baik di kelas maupun di luar ruang kelas. Hal lain yang perlu diperhatikan adalah bahwa sangat tidak mungkin institusi pendidikan bisa menciptakan karakter siswanya jika pembelajaran tidak dengan bertatap muka. Tentu, banyak kendala yang dihadapi guru dan siswa yang muncul dalam pembelajaran metode daring yang tidak bisa dihindari. Sebagaimana dijelaskan di atas, banyak satuan pendidikan yang terkendala dengan koneksi jaringan internet yang tidak ada.
Impasses territoriais:
Authors: Santos Luan Moraes dos 
Published: August 2022

Buscamos nesse artigo analisar a história recente do povo Xukuru-Kariri, evidenciando a presença indígena a partir da retomada territorial da gleba conhecida como Fazenda Jarra, em Palmeira dos Índios-AL. Discutindo as formas de organização política tanto dos índios quanto das elites, sobretudo no que diz respeito ao Movimento Palmeira de Todos, ocorrido em 2013, numa tentativa de elucidar rupturas e continuidades na disputa territorial, tendo como pressupostos teóricos as reflexões de Fredrik Barth (1995), Milton Santos (1998) e Manuel Correia de Andrade (2004).
Sağlıkta Şiddet: Bibliyometrik Bir Analiz
Authors: YABA Mevsim , DEMİR YURTSEVEN Ecem , TÜRKMENOĞLU Bahar , DAŞLI Yılmaz 
Published: August 2022

This study aims to reveal the current situation of the articles written on violence in health by using the bibliometric analysis method, which has become a common problem of all societies. Although there are many studies on various subjects using the bibliometric analysis method, there is no study conducted using Web of Science (WoS) data on violence in health. The data set of the study consists of 13,130 research articles published between 2017-2021 by scanning in WoS on February 3, 2021, using the themes of violence in health, violence and health, violence in healthcare organizations, and violence in health institutions by including titles, abstracts, and keywords. The data were analyzed using the VOSviewer software (version 1.6.17).
The analysis indicated that the United States is the first with 7226 research articles among 165 countries in 5 years, while Turkey is 24th with 145. According to the number of institution-based studies, Columbia University, which ranks first, published 323 research articles, the studies published in the USA received the highest citations (52,093), and Turkey received 527 citations in 5 years. It was found that the most-cited author was Richard Lowry with 1334 citations. It was found that the most frequently used keywords in studies on violence in health were intimate partner violence, violence, violence in health, violence and health, mental health, and violence and domestic violence. This study also revealed that academic studies on violence in health tend to increase over the years.
Portable Bone Imaging Devices for Screening and Diagnosing Osteoporosis
Authors: Khangura Sara D. , Mahood Quenby 
Published: August 2022

Limited evidence describing the clinical utility of 2 types of portable bone imaging devices suggest that they may be comparable to DXA for predicting the incidence of fracture, but the findings are uncertain.
Incorporating 1 type of portable bone imaging device into a screening and diagnosis management pathway for osteoporosis was more cost-effective in a Finnish context, compared to an osteoporosis management approach that did not include the portable bone imaging device.
Two guidelines were found that have recommendations about portable bone imaging devices for screening and diagnosing osteoporosis. Both guidelines reported limited evidence on the use of portable bone imaging devices.
Trastornos en los hábitos alimentarios en niños y adolescentes durante el confinamiento en Ecuador, 2021
Authors: Calderón Herrera Nataly Estefanía , Grandes Hidalgo Jenny Susana , Carrión Suarez Freddy , Erazo Cheza Carlos Vinicio 
Published: August 2022

Introducción: Se ha reportado que el confinamiento domiciliario por la pandemia de COVID 19 ha ocasionado cambios importantes en los hábitos alimentarios de niños y adolescentes a nivel mundial, comprometiendo su estado nutricional por el incremento de la prevalencia de desnutrición y obesidad. El objetivo del presente estudio fue identificar trastornos en los hábitos alimentarios en niños y adolescentes durante el confinamiento en Ecuador.
Metodología: El presente estudio transversal, incluyó a 1,446 padres o cuidadores primarios de niños y adolescentes ecuatorianos. Con una muestra probabilística se realizó una encuesta validada. Se realizó un análisis descriptivo e inferencial de las variables del estudio con el software estadístico SPSS Versión 25.
Resultados: En confinamiento el 67.8 % (n= 981) de encuestados no realizó cambios en la alimentación. El 79.8 % (n= 791) de las personas ya tenían hábitos saludables y los mantuvo durante el confinamiento, el 20.2 % (n=200) cambió sus hábitos de saludables a no saludables. El 67.5 % (n=307), no tenían hábitos alimentarios saludables y continuaron esta práctica, el 32.5 % (n=148) pasaron de tener hábitos no saludables a saludables. La presencia de “hábitos saludables” se asoció con familias biparentales (OR 1.29, IC 95% 1.04-1.61, P <0.05), 1 a 2 de personas viviendo en la casa (OR 0.56, IC 95% 0.34-0.93, P <0.05), con trabajo presencial (OR 0.69, IC 95% 0.55-0.86, P<0.05), trabajo en relación de dependencia (OR 0.62, IC 95% 0.48-0.80, P <0.05), y cumplimiento de la cuarentena (OR 1.55, IC 95% 1.21-1.98, P<0.05).
Conclusión: Niños y adolescentes en Ecuador, en su mayoría no presentaron cambios en los hábitos de alimentación, siendo estos saludables.
News Production and Consumption Practices in Online Journalism: A Cross-Platform Review
Authors: KARAOĞLU Gülhanım 
Published: August 2022

Internet-based technologies, which mark a revolutionary period in journalism, have revealed new understandings in journalism. This change in the news media has affected the established forms of production and consumption, and has transformed traditional relations and understandings. Expanding information distribution capacities and reader expectations growing, differentiating and specializing necessitate using new communication technologies more effectively. Social media platforms and online environments, which provide additional channels to reach the reader, both open new areas for news producers and reveal different usage patterns from traditional media for consumers.
The study investigates the trends in news production, distribution, and consumption in different social media platforms as an alternative field. In the study, Twitter, Instagram, and Telegram platforms were discussed, and content production, distribution, and consumption styles were examined in the context of journalism, based on the assumption that Telegram is an alternative channel for creating public opinion, increasing interaction and creating their brands for journalists. In this context, Twitter, which functions more as a news sharing application, Instagram, which has increased in popularity in recent years, and Telegram, which stands out with its bot and channel creation features, are evaluated. The shares on the Cia Medya Telegram channel, Cia Haber Instagram page and Cia Haber Twitter page, which constitute the sample of the research, were analyzed by content analysis method, and it was concluded that the Telegram platform is used more actively in content production, distribution and interaction.
Bursa Gazetesinde (1891-1892) Kadına Dair Haberlerin Analizi
Authors: ÖZÇELİK Mürvet 
Published: August 2022

Bu makale 1890 yılında Hüdavendigâr Vilayetinde yerel bir gazete olarak yayınlanmaya başlayan Bursa gazetesindeki kadına dair haberlerin analizini yaparak kadının bu dönemdeki toplumsal konumunu gazete haberleri üzerinden ortaya koymayı amaçlamaktadır. Çalışmada 19.yüzyıl sonunda sosyal, ekonomik ve nüfus bakımından Bursa toplumsal hayatının durumuna ve Bursa basın hayatına genel olarak değinilmiştir. Gazetenin 49-95 arasındaki sayıları taranıp, burada yer alan kadına dair haberler analiz edilmiş, bulgular içerik analizine tabi tutularak yorumlanmış ve temalar oluşturulmuştur.
Gazetede yer alan kadına dair haberler, bahsi geçen dönemde kadının toplumsal hayatta fail ya da mağdur olarak yer aldığı olaylar hakkında bilgi sunmakta, bu olayların aktarıldığı gazete haberlerinde kadının nasıl sunulduğuna dair verilere de ulaşmamızı sağlamaktadır. Bu veriler bize incelenen dönemde kadının mağduriyetine yol açan durumların başında aile içi şiddetin geldiğini göstermektedir. Bunun yanında kadınların gündelik hayatta darp, taciz ve tecavüz gibi mağduriyetler yaşadığı, aynı zamanda fiziksel şiddete de maruz kaldıkları görülmüştür.
Çalışmada kadına dair gazete haberleri, hem kadın hem basın hem de yerel tarihle desteklenen sosyolojik bir bakışla analiz edilmiştir. Bu analizin, kadına dair çalışmalara, farklılıkları ya da benzerlikleri kıyaslama ve karşılaştırma imkânı sunması bakımından öneme sahip olduğu düşünülmektedir.
Prediction of abnormalities in heart beat sounds using convolutional neural networks
Authors: Thendral P , Karkuzhali S. , Siyon V. A. , Sweeton C. Jeyanth Kallis 
Published: August 2022

Worldwide physicians prefer to use physical stethoscope and they listen to the heart beat sound and its rhythm to diagnose various heart conditions. In this work various abnormalities that happened in heart will be reflected in the sound of the heartbeat. In this work we have created a classification system which is based on Convolutional Neural Network (CNN) to analyze the heart beat sound to predict the abnormalities. Heart beat sound is converted to spectrogram images and then CNN is trained with those images. In order to reduce the computational time, pooling is done, so that it reduces the parameters by taking particular pixel from particular part of pixels. The parameters in CNN are varied in the convolution and pooling layers to enhance the accuracy of classification of heart beat sound. Experiment is carried out by varying number of convolutional layers and by changing the pooling methods for various combinations of CNN models and the results are analyzed to find the optimal combination which can suit for sound analysis.
clinical study on the success rate of endoscopic dacryocystorhinostomy
Authors: Swathi Akula , Preethi Akula Satya , Teja Ch. Bhava , Bandela Pandit Vinodh , Kumar Meela Ranjith 
Published: August 2022

Background: Endoscopic dacryocystorhinostomy (DCR) has advantages like excellent homeostasis, absence of scar, less post operative pain and edema. However, less literature is available on success rate. Aim and objectives: To evaluate the success rate of endoscopic DCR. After 3 months DCR success rate was estimated based on relief perceived by the patient, free flow of saline on syringing through the lower canaliculus and presence of patent stoma visualized on rigid endoscopy. Materials and methods: 25 Epiphora patients underwent anterior rhinoscopy, nasal endoscopy, syringing, CT scan and DCR. They were evaluated for the relief of symptoms at 2 week and 3 month respectively. Results: Mostly 76% females with mean age (females:54.4/Males:59) were present. Symptoms: watering of eyes (100%), swelling (92%) and mucopurulent discharge (68%). Disease on the right side- 40% and left side -56% only 4% were with bilateral disease. On follow up after 3months 96% patients reported symptomatic relief of complaints and 4% had granulations at the neoostium and synechiae between nasal and lacrimal mucosa which were removed and subsequent relief of symptoms and free flow of saline on syringing were seen. Conclusion: Endoscopic DCR is a safe, minimally invasive, surgical procedure with 96% functional success rate.