bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between three age-stratified cohorts reveals poor prognosis of young patients with tongue carcinoma
Authors: Baba Daisuke , Matsuura Kazuto , Wakabayashi Masashi , Morishita Yohei , Nishiya Yukio , Okano Wataru , Tomioka Toshifumi , Shinozaki Takeshi , Hayashi Ryuichi 
Published: September 2022

ObjectivesInvestigation of the prognosis of young patients with tongue carcinoma has been the focus of several recent studies aimed at improving future precision treatment. Most studies have been two-cohort investigations comparing young and older patients, who have wide discrepancies in prognosis. Older patients, especially those aged &gt;70 years, often have a poor general condition. This affects the prognosis of the older cohort and accounts for the discrepancies observed in two-cohort studies. Accordingly, in this study, older patients (aged ≥71 years) were separated and compared to young and middle-aged patients.MethodsA total of 257 patients with oral tongue carcinoma referred during 2011–2017 were analyzed. Patients were sorted into young (aged ≤40 years), middle-aged (aged ≥41 and ≤70 years), and older (aged ≥71 years) groups. Overall survival (OS) and disease-free survival (DFS) were compared among the groups. Furthermore, patterns of recurrence rates were compared.ResultsCompared with young patients, there was no difference in OS or DFS for older patients (hazard ratio [HR]: 1.2, 95% confidence interval [CI]: 0.5–2.7 and HR: 0.7, 95% CI: 0.4–1.2, respectively) in a multivariate analysis. There was also no difference in OS (HR: 0.6, 95% CI: 0.3–1.3) for middle-aged patients. However, middle-aged patients had low recurrence rates (HR: 0.5, 95% CI: 0.3–0.8). With respect to the recurrence type, middle-aged patients had a low local recurrence rate (HR: 0.3, 95% CI: 0.1–0.7).ConclusionThree-cohort studies should be conducted to evaluate whether the prognosis of young patients with tongue carcinoma is truly poor in terms of future precision treatment.
Lymph node ratio is a superior predictor in surgically treated early-onset pancreatic cancer
Authors: Zheng Yangyang , Lu Zhenhua , Shi Xiaolei , Tan Tianhua , Xing Cheng , Xu Jingyong , Cui Hongyuan , Song Jinghai 
Published: September 2022

BackgroundThe prognostic performance of four lymph node classifications, the 8th American Joint Committee on Cancer (AJCC) Tumor Node Metastasis (TNM) N stage, lymph node ratio (LNR), log odds of positive lymph nodes (LODDS), and examined lymph nodes (ELN) in early-onset pancreatic cancer (EOPC) remains unclear.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was searched for patients with EOPC from 2004 to 2016. 1048 patients were randomly divided into training (n = 733) and validation sets (n = 315). The predictive abilities of the four lymph node staging systems were compared using the Akaike information criteria (AIC), receiver operating characteristic area under the curve (AUC), and C-index. Multivariate Cox analysis was performed to identify independent risk factors. A nomogram based on lymph node classification with the strongest predictive ability was established. The nomogram’s precision was verified by the C-index, calibration curves, and AUC. Kaplan–Meier analysis and log-rank tests were used to compare differences in survival at each stage of the nomogram.ResultsCompared with the 8th N stage, LODDS, and ELN, LNR had the highest C-index and AUC and the lowest AIC. Multivariate analysis showed that N stage, LODDS, LNR were independent risk factors associated with cancer specific survival (CSS), but not ELN. In the training set, the AUC values for the 1-, 3-, and 5-year CSS of the nomogram were 0.663, 0.728, and 0.760, respectively and similar results were observed in the validation set. In addition, Kaplan–Meier survival analysis showed that the nomogram was also an important factor in the risk stratification of EOPC.ConclusionWe analyzed the predictive power of the four lymph node staging systems and found that LNR had the strongest predictive ability. Furthermore, the novel nomogram prognostic staging mode based on LNR was also an important factor in the risk stratification of EOPC.
Incidence of venous thromboembolism after surgery for adenocarcinoma in situ and the validity of the modified Caprini score: A propensity score-matched study
Authors: Cai Yong-sheng , Dong Hong-hong , Li Xin-yang , Ye Xin , Chen Shuo , Hu Bin , Li Hui , Miao Jin-bai , Chen Qi-rui 
Published: September 2022

BackgroundRecently, the new World Health Organization (WHO) tumor classification removed adenocarcinoma in situ (AIS) from the diagnosis of lung cancer. However, it remains unclear whether the “malignancy” item should be assessed when the modified Caprini Risk Assessment Model (RAM) is used to assess venous thromboembolism (VTE) risk in AIS. The purpose of our study is to assess differences between AIS and stage IA adenocarcinoma (AD) from a VTE perspective.MethodsA retrospective study was performed on AIS and IA adenocarcinoma in our hospital from January 2018 to December 2021, and divided into AIS group and AD group. Propensity score matching (PSM) was used to compare the incidence of VTE and coagulation function, and to analyze whether the RAM is more effective when the “malignancy” item is not evaluated in AIS.Results491 patients were included after screening, including 104 patients in the AIS group and 387 patients in the AD group. After PSM, 83 patients were matched. The incidence of VTE and D-dimer in the AIS group was significantly lower than that in the AD group (P&lt;0.05).When using the RAM to score AIS, compared with retaining the “malignancy” item, the incidence of VTE in the intermediate-high-risk group was significantly higher after removing the item (7.9% vs. 36.4%, P=0.018), which significantly improved the stratification effect of the model.ConclusionsThe incidence of postoperative VTE in AIS was significantly lower than that in stage IA adenocarcinoma. The stratification effect was more favorable when the “malignancy” item was not evaluated in AIS using the RAM.
Ultrasomics prediction for cytokeratin 19 expression in hepatocellular carcinoma: A multicenter study
Authors: Zhang Linlin , Qi Qinghua , Li Qian , Ren Shanshan , Liu Shunhua , Mao Bing , Li Xin , Wu Yuejin , Yang Lanling , Liu Luwen , Li Yaqiong , Duan Shaobo , Zhang Lianzhong 
Published: September 2022

ObjectiveThe purpose of this study was to investigate the preoperative prediction of Cytokeratin (CK) 19 expression in patients with hepatocellular carcinoma (HCC) by machine learning-based ultrasomics.MethodsWe retrospectively analyzed 214 patients with pathologically confirmed HCC who received CK19 immunohistochemical staining. Through random stratified sampling (ratio, 8:2), patients from institutions I and II were divided into training dataset (n = 143) and test dataset (n = 36), and patients from institution III served as external validation dataset (n = 35). All gray-scale ultrasound images were preprocessed, and then the regions of interest were then manually segmented by two sonographers. A total of 1409 ultrasomics features were extracted from the original and derived images. Next, the intraclass correlation coefficient, variance threshold, mutual information, and embedded method were applied to feature dimension reduction. Finally, the clinical model, ultrasonics model, and combined model were constructed by eXtreme Gradient Boosting algorithm. Model performance was assessed by area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and accuracy.ResultsA total of 12 ultrasomics signatures were used to construct the ultrasomics models. In addition, 21 clinical features were used to construct the clinical model, including gender, age, Child-Pugh classification, hepatitis B surface antigen/hepatitis C virus antibody (positive/negative), cirrhosis (yes/no), splenomegaly (yes/no), tumor location, tumor maximum diameter, tumor number, alpha-fetoprotein, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, glutamyl-transpeptidase, albumin, total bilirubin, conjugated bilirubin, creatinine, prothrombin time, fibrinogen, and international normalized ratio. The AUC of the ultrasomics model was 0.789 (0.621 – 0.907) and 0.787 (0.616 – 0.907) in the test and validation datasets, respectively. However, the performance of the combined model covering clinical features and ultrasomics signatures improved significantly. Additionally, the AUC (95% CI), sensitivity, specificity, and accuracy were 0.867 (0.712 – 0.957), 0.750, 0.875, 0.861, and 0.862 (0.703 – 0.955), 0.833, 0.862, and 0.857 in the test dataset and external validation dataset, respectively.ConclusionUltrasomics signatures could be used to predict the expression of CK19 in HCC patients. The combination of clinical features and ultrasomics signatures showed excellent effects, which significantly improved prediction accuracy and robustness.
Evaluation of in ovo feeding of low or high mixtures of cysteine and lysine on performance, intestinal morphology and physiological responses of thermal-challenged broiler embryos
Authors: Ajayi O. I. , Smith O. F. , Oso A. O. , Oke O. E. 
Published: September 2022

The objective of this study was to evaluate the effect of in ovo feeding cysteine, lysine or their combinations on the perinatal and post-hatch physiological responses of broiler embryos exposed to heat stress during incubation. A total of two thousand fertile eggs of broiler breeders (Ross 308) flock (at 38 weeks of age) were used for this study. In the first 10 days, the eggs were incubated using the conventional protocol of relative humidity and temperature of 55% and 37.8°C respectively. From day ten onward, the temperature was increased to 39.6°C for 6 h per day. On day 17.5, 1,500 eggs with the evidence of living embryos were randomly selected and assigned to 6 treatments having five replicates of 50 eggs each. The treatments were: un-injected eggs (UI), eggs injected with only 0.5 ml distilled water (DW), 3.5 mg/egg cysteine (CY), 2mg/egg lysine (LY), 3.4 mg cysteine+2 mg lysine (CLH) and 1.7 mg cysteine+1 mg lysine (CLL). On day 21, the hatchability, anatomical characteristics, chick quality and the antioxidant status of the chicks were evaluated. During the post-hatch phase, data were collected on the haematology, biochemical parameters, growth performance and intestinal morphology of the birds. The results revealed that the hatchability of CY chicks was higher (p&lt; 0.05) than in the other treatments, while the lowest values were recorded in CLH. The hatching muscle of the chicks of CLL was similar to those of CY but higher (p&lt; 0.05) than the others. The MDA of DW and UI chickens was similar and higher than birds in the other treatment groups. The serum SOD of CLL birds was comparable to that of CY but higher than the values recorded in the other treatments. The final weights of CLL chickens were similar to those of LY but significantly higher (p&lt; 0.05) than those of the other treatments. The duodenal villus heights of the birds of CLL were higher than those of the other treatment groups, whereas the villus height of the birds of CLH was higher than those of UI, DW and CY. Overall,in ovofeeding of cysteine alone improved the hatchability of thermally-challenged broiler embryos. In contrast, a low-dose mixture of cysteine plus lysine improved the post-hatch growth performance.
The importance of incorporating geology, soil, and landscape knowledge in freshwater farm planning in Aotearoa New Zealand
Authors: Burkitt Lucy , Bretherton Michael 
Published: September 2022

Over half of Aotearoa New Zealand’s (NZ’s) land area is under agriculture or forestry production. Long term monitoring has shown declines in freshwater quality in regions with the most intensive agriculture. The New Zealand government has historically focused on reducing the impact of agriculture on water quality through its Resource Management Act 1991. Lack of improvement in freshwater quality has resulted in the 2020 Essential Freshwater package of reforms which will require all pastoral farms &gt;20 ha in size and all arable farms &gt; 5 ha in size to develop a Freshwater Farm Plan (FFP) by a certified Freshwater Farm Planner. As far as we are aware, New Zealand is the first country in the world to mandate compulsory FFPs. This paper describes the key geological, soil, and landscape factors that need to be considered in an FFP for it to be successful in meeting the 2020 Essential Freshwater objectives. We argue that a greater emphasis should be placed on understanding a farm’s natural resources, as they provide the physical interface between the farming system and both the freshwater and atmospheric ecosystems. Documenting our learning in this area could assist other countries considering Freshwater Farm Planning as a strategy to reduce the impact of agriculture on freshwater quality.
Treatment of Periprosthetic Joint Infection and Fracture-Related Infection With a Temporary Arthrodesis Made by PMMA-Coated Intramedullary Nails – Evaluation of Technique and Quality of Life in Implant-Free Interval
Authors: Walter Nike , Baertl Susanne , Lang Siegmund , Szymski Dominik , Weber Johannes , Alt Volker , Rupp Markus 
Published: September 2022

BackgroundAntimicrobial coating of intramedullary nails with polymethyl methacrylate (PMMA) bone cement promises infection control and stabilization for subsequent bone healing. However, when removing the implant, bone cement can debond and remain in the medullary cavity of the long bones, representing a nidus for reinfection. This work presents a technique comprising reinforcement of PMMA-coated intramedullary nails with cerclage wire to prevent such problems in patients treated for fracture-related infection (FRI) or knee periprosthetic joint infection (PJI) with a static spacer as temporary arthrodesis allowing weight-bearing in the implant-free interval. Outcomes of this surgical treatment were evaluated in terms of (i) associated complications and (ii) patient-reported quality of life.MethodsIn this retrospective case series, 20 patients with PJI (n = 14, 70%) and FRI (n = 6, 30%) treated with PMMA-coated intramedullary nails reinforced with cerclage wire between January 2021 and July 2021 were included. Quality of life during the implant-free interval was evaluated with the EQ-5D, SF-36, and an ICD-10 based psychological symptom rating and compared with previously analyzed cohorts of successfully treated PJI and FRI patients in whom eradication of infection and stable bone consolidation was achieved.ResultsComplications during the implant-free interval comprised a broken nail in one case (5.0%) and a reinfection in one case (5.0%). Coating-specific side effects and cement debonding during removal did not occur. The mean physical health component score of SF-36 was 26.1 ± 7.6, and the mean mental health component score reached a value of 47.1 ± 18.6. The mean EQ-5D index value was 0.36 ± 0.32 and the mean EQ-5D visual analogue scale rating was 47.4 ± 19.4. The scores were significantly lower than those in the successfully treated FRI cohort but not in the PJI cohort. The mean ICD-10-based symptom rating scores revealed psychological symptom burden on the depression scale and enhanced levels of anxiety in comparison with healed FRI and PJI patients.ConclusionReinforcement of PMMA bone cement-coated implants seems to be a reasonable treatment option to create a temporary arthrodesis, preventing detachment of the bone cement when the implant was removed.Level of Evidence: IV.
SIMULAÇÃO DO PROCESSO DE PRODUÇÃO DO ADAPTADOR HIDROSTÁTICO UTILIZANDO SOFTWARE ARENA STUDENT 12 ®
Authors: Pereira Vitor , Romanhol Caio , Cardoso João Vytor , Pereira Barizon Yago , Nazaré Tiago 
Published: September 2022

Resumo
A usinagem consiste em um processo mecânico de desgaste da matéria bruta que da origem a uma peça de formato especifico. Uma alternativa a outros tipos de processos de produção, como a moldagem e a fundição. O estudo realizou uma pesquisa em cima da fabricação de um certo modelo de peça, produzida através do processo de usinagem, utilizando as maquinas torno convencional e fresadora, foi cronometrado cada etapa desse processo e feita uma simulação no software Arena Student 12 ® com o intuito de realizar vários testes para saber onde se encontra os problemas na produção. O propósito é verificar onde e em quais etapas podem ser diminuído o tempo de execução, buscando melhoria continua e eliminando retrabalhos, pois foi visto que em uma das etapas o processo de retrabalho tem um longo período de duração, o que pode ocasionar um descontrole na linha de produção.
Inovasi Kemasan Dan Pemasaran Sebagai Daya Tarik Produk Jajanan Tradisional Di Kampung Jajanan Kelurahan Mlatibaru Semarang
Authors: Widyaswati Rahmatya , Tri Widiastuti C , Meiriyanti Rita 
Published: September 2022

Program “Gerbang Hebat” dan kampung tematik merupakan salah satu program pemerintah daerah dan masyarakat dalam pemberdayaan masyarakat yang inovatif dalam penanganan program kemiskinan dan pengangguran di Kota Semarang. Dengan adanya program “ Gerbang Hebat” dan Kampung Tematik diharapkan mampu mengurangi angka kemiskinan dan pengangguran serta mengurangi daerah-daerah kumuh , memberdayakan masyarakat dan merubahnya menjadi destinasi wisata yang baru. Dengan adanya program “Gerbang Hebat” mampu mengatasi permasalahanterkait dengan kualitas lingkungan rumah tinggal ,prasarana dasar pemukiman, serta mampu meningkatkan pendapatan melalui pemberdayaan masyarakat yang inovatf
Pengabdian masyarakat bertujuan untuk memberdayakan masyarakat untuk mengembangkan keahlian dalam berwirausaha mandiri sehingga dapat membantu meningkatkan kualitas hidup warga kelurahan Mlatibaru Semarang.
Metode pengabdian masyarakat dilakukan dengan melakukan persiapan pelatihan yakni pembuatan proposal, menetapkan tempat pengabdian, pelaksanaan pengabdian, pembuatan laporan dan evaluasi, Tujuan adanya evaluasi dilaksanakan adalah untuk mengukur apakah pelatihan efektif atau tidak. Hasil dari pengabdian ini yakni bahwa ibu-ibu warga kelurahan Mlatibaru Semarang sangat termotivasi untuk berwirausaha, sehingga dapat menambah penghasilan keluarga.

Kata Kunci : pemberdayaan, rumah tangga, usaha mandiri
Penyuluhan Teknik Dasar Tinju Amatir Junior Pertina Kota Surakarta
Authors: Adhi Kusuma Danang , Mahardika Wisnu , Widagdo  , Yuliyanto Rustam 
Published: September 2022

ABSTRAK
Kegiatan pengabdian ini dilaksanakan pada tanggal 17 Maret 2022 pukul 10.00-16.00 WIB bertempat di Sasana Tinju PERTINA Surakarta. Peserta berjumlah 20 atlit. Peserta sangat antusias untuk mengikuti materi penyuluhan. Sebelum praktek diberikan, secara singkat peserta diberikan materi tentang teknik Dasar Tinju selain itu teknik dasar permainan tinju dan juga latihan Komponen teknik dasar tinju dapat meningkat kemampuan pribadi. Metode yang digunakan adalah dengan bentuk kegiatan dalam pelatihan olahraga petanque ini dengan menggunakan pendekatan langsung, demontrasi, diskusi, praktek dan evaluasi terhadap serapan dari atlit yang ikut langsung di lokasi yaitu di Sasana Tinju PERTINA Surakarta dengan teori dan langsung praktek di dilapangan. Pelatihan ini diberikan supaya peserta mengetahui dan memahami tentang penerapan latihan teknik dasar permainan Tinju dalam peningkatan permainan Tinju dengan benar, sehinga dapat menunjang pencapaian prestasi Tinju yang optimal. Materi yang saya sampaikan pada kegiatan ini adalah mengenai teknik dasar permainan olahraga tinju dan program latihan praktek teknik dasar untuk penunjang kemampuan permainan tinju.
Kata Kunci : Penyuluhan, Permainan Tinju Amatir
Penataan Infrastruktur Saluran dan Taman Di Jalan Kahuripan Utama Kelurahan Sumber
Authors: Hartanto Tri , Yuuono A. Bamban , Krisnawati Eny , Karsono Danarti , Ismadi  
Published: September 2022

Jalan Kahuripan Utama yang merupakan jalan permukiman kampung Kahuripan RW.04, Kelurahan Sumber, Kecamatan Banjarsari timbul permasalahan tersumbatnya air saluran. Pada saat hujan lebat karena kondisi saluran yang tersumbat mengakibatkan genangan di Kawasan permukiman tersebut. Setelah diidentifikasi oleh tokoh masyarakat bersama tim pengabdian Fakultas Teknik UTP Surakarta, masalah timbul akibat rusaknya sebagai saluran dan banyaknya endapan sedimen walet. Di salah satu perempatan jalan terdapat persimpangan saluran drainase permukiman dengan saluran pertanian Mangkunegaran. Berdasarkan hasil survey lapangan, kemudian musyawarah dengan tokoh masyarakat tim pengabdian menyampaikan alternatif pemecahan, yaitu perbaikan saluran dengan mengganti dengan saluran U-ditch. Selain kuat, mudah pengerajaan, juga mudah didalam pemeliharaannya. Kemudian diatas U-dtch akan dimanfaatkan untuk taman, dengan tanaman perdu untuk keasrian lingkungan. Saluran drainase direncanakan sampai ke aliran sungai, terbagi menjadi tiga segmen dengan konstruksi U-ditch 500x500 sepanjang 81,75 m, Box Culvert 500x500x1000mm sepanjang 6 m dan U-ditch 500x600 sepanjang 73,4 m. Rencana anggaran biaya untuk pekerjaan saluran drainase dari perhitungan didapat Rp. 262.760.000,00.
Kata Kunci: penataan, saluran, taman, jalan Kahuripan Utama, Surakarta.
Scheme of Arrangement in the UK Takeover Market: Does it Make a Difference in Firms’ Survival to be Tendered?
Authors: Alqobali Hala , Alandejani Maha 
Published: September 2022

Compared with tender offers, bidders can easily obtain target firms in the scheme of arrangements. This study investigates the impact of deal and target characteristics on 803 firms’ survival to be taken over by a scheme of arrangement or a tender offer in the UK takeover market, during the 1995 to 2018 period, through applying survival analysis, including continuous (PH Cox, Weibull) and discrete-time (complementary log-log) hazard models. The findings indicate that the explanatory variables of target and deal characteristics play a significant role in both the scheme of arrangement and tender offer deals. Firm size, financial crises, the takeover Code shock, and the termination fees paid by a target firm increase the probability of a takeover of the target firm to be implemented by way of a scheme. Acquirers who are publicly listed and own a large stake in the target firm before the takeover intend to reduce the target firm’s probability of being schemed.

Received: 21 April 2022 / Accepted: 15 August 2022 / Published: 2 September 2022
The Portrayal of Gender in the Arabic Construction
Authors: Muassomah Muassomah , Abdullah Irwan , Hasanah Umdatul , Kulsum Nyimas Umi , Muzakki Akhmad 
Published: September 2022

The portrayal of gender in the Arabic construction has shown the existence of gender inequality. The Arabic language is a highly gendered language, with every word having its own male or female identity, and this has legitimized the existing gender disparities in Arabic society. Men and women are supposed to have particular characteristics, which are similarly reflected within specific spaces and positions. This article thus employs a qualitative approach to understand the gendered identities of Arabic-language words. Data were collected by reading Arabic-language texts and recorded words that highlighted the disparity between men and women. This article finds significant disparity, with words identified as male connoting strength, might, dominance, activeness, dynamicity, and independence and words identified as female connoting marginalization, subordination, passiveness, and dependence. This study highlights the unfair portrayal of women in Arabic constructions has legitimized gender inequality in Muslim society.

Received: 10 July 2022 / Accepted: 25 August 2022 / Published: 2 September 2022