bluuebunny/crossref_metadata_2025_split huggingface dataset:
An overview of progressive advancement in ultra-high performance concrete with steel fibers
Authors: Alkadhim Hassan Ali , Amin Muhammad Nasir , Ahmad Waqas , Khan Kaffayatullah , Umbreen-us-Sahar  , Al-Hashem Mohammed Najeeb , Mohamed Abdullah 
Published: December 2022

A progressive advance in the construction sector is attained by employing ultra-high performance concrete (UHPC) technology. Rigorous efforts have been made in this research domain to have remarkable quality levels with 150 MPa or more strength and significant durability, which was impossible previously. Steel fiber incorporation in UHPC is vital in improving its mechanical characteristics. This review on the incorporation of steel fibers in UHPC evaluates, identifies, and synthesizes research outcomes for creating a summary of current evidence that can contribute to evidence-based practice. This study summarized a review of the literature on steel fibers’ effect on UHPC, intending to explore its essential aspects. The aim is to summarize the literature in this research domain and provide guidance for future research. Moreover, the basic requirements and materials, mixing and casting, mechanical properties, modern applications, advantages and disadvantages, and future perspectives associated with steel fibers reinforced UHPC in the construction sector are discussed. It is revealed from the conducted analysis that the most widely applied keyword is “steel fibers.” Due to the graphical illustration of the contributing studies, the current work may benefit academic scholars in sharing novel techniques and ideas and establishing collaborative efforts. Furthermore, the present work reveals that steel fibers have the potential to enhance the mechanical properties of UHPC; however, the large-scale production and applications of steel fiber-reinforced UHPC are controlled by parameters like fiber content and geometry.
Selective activation of the hypothalamic orexinergic but not melanin-concentrating hormone neurons following pilocarpine-induced seizures in rats
Authors: He Zhenquan , Wang Xiao , Ma Kang , Zheng Leyi , Zhang Yan , Liu Chunhong , Sun Tao , Wang Peng , Rong Weifang , Niu Jianguo 
Published: December 2022

IntroductionSleep disorders are common comorbidities in patients with temporal lobe epilepsy (TLE), but the underlying mechanisms remain poorly understood. Since the lateral hypothalamic (LH) and the perifornical orexinergic (ORX) and melanin-concentrating hormone (MCH) neurons are known to play opposing roles in the regulation of sleep and arousal, dysregulation of ORX and MCH neurons might contribute to the disturbance of sleep-wakefulness following epileptic seizures.MethodsTo test this hypothesis, rats were treated with lithium chloride and pilocarpine to induce status epilepticus (SE). Electroencephalogram (EEG) and electromyograph (EMG) were recorded for analysis of sleep-wake states before and 24 h after SE. Double-labeling immunohistochemistry of c-Fos and ORX or MCH was performed on brain sections from the epileptic and control rats. In addition, anterograde and retrograde tracers in combination with c-Fos immunohistochemistry were used to analyze the possible activation of the amygdala to ORX neural pathways following seizures.ResultsIt was found that epileptic rats displayed prolonged wake phase and decreased non-rapid eye movement (NREM) and rapid eye movement (REM) phase compared to the control rats. Prominent neuronal activation was observed in the amygdala and the hypothalamus following seizures. Interestingly, in the LH and the perifornical nucleus, ORX but not MCH neurons were significantly activated (c-Fos+). Neural tracing showed that seizure-activated (c-Fos+) ORX neurons were closely contacted by axon terminals originating from neurons in the medial amygdala.DiscussionThese findings suggest that the spread of epileptic activity from amygdala to the hypothalamus causes selective activation of the wake-promoting ORX neurons but not sleep-promoting MCH neurons, which might contribute to the disturbance of sleep-wakefulness in TLE.
Effect of dietary inflammatory potential on the aging acceleration for cardiometabolic disease: A population-based study
Authors: Hu Yuanlong , Wang Xiaojie , Huan Jiaming , Zhang Lei , Lin Lin , Li Yuan , Li Yunlun 
Published: December 2022

Background/AimOptimized dietary patterns have been considered an important determinant of delaying aging in cardiometabolic disease (CMD). Dietary pattern with high-level dietary inflammatory potential is a key risk factor for cardiometabolic disease, and has drawn increasing attention. The aim of this study was to investigate whether dietary pattern with high dietary inflammatory potential was associated with aging acceleration in cardiometabolic disease.Materials and methodsWe analyzed the cross-sectional data from six survey cycles (1999–2000, 2001–2002, 2003–2004, 2005–2006, 2007–2008, and 2009–2010) of the National Health and Nutritional Examination Surveys (NHANES). A total of 16,681 non-institutionalized adults and non-pregnant females with CMD were included in this study. Dietary inflammatory index (DII) was used to assess the dietary inflammatory potential. The two age acceleration biomarkers were calculated by the residuals from regressing chronologic age on Klemera-Doubal method biological age (KDM BioAge) or Phenotypic Age (PhenoAge), termed “KDMAccel” and “PhenoAgeAccel.” A multivariable linear regression accounting for multistage survey design and sampling weights was used in different models to investigate the association between DII and aging acceleration. Four sensitivity analyses were used to ensure the robustness of our results. Besides, we also analyzed the anti-aging effects of DASH-type dietary pattern and “Life’s Simple 7”.ResultsFor 16,681 participants with CMD, compared with the first tertile of DII after adjusting for all potential confounders, the patients with second tertile of DII showed a 1.02-years increase in KDMAccel and 0.63-years increase in PhenoAgeAccel (KDMAccel, β = 1.02, 95% CI = 0.64 to 1.41, P &lt; 0.001; PhenoAgeAccel, β = 0.63, 95% CI = 0.44 to 0.82, P &lt; 0.001), while the patients with the third tertile of DII showed a 1.48-years increase in KDMAccel and 1.22-years increase in PhenoAgeAccel (KDMAccel, β = 1.48, 95% CI = 1.02 to 1.94, P &lt; 0.001; PhenoAgeAccel, β = 1.22, 95% CI = 1.01 to 1.43, P &lt; 0.001). In addition, DASH-type dietary pattern was associated with a 0.57-years reduction in KDMAccel (β = −0.57, 95% CI = −1.08 to −0.06, P = 0.031) and a 0.54-years reduction in PhenoAgeAccel (β = −0.54, 95% CI = −0.80 to −0.28, P &lt; 0.001). The each one-unit increase in CVH score was associated with a 1.58-years decrease in KDMAccel (β = −1.58, 95% CI = −1.68 to −1.49, P &lt; 0.001) and a 0.36-years in PhenoAgeAccel (β = −0.36, 95% CI = −0.41 to −0.31, P &lt; 0.001).ConclusionAmong CMD, the dietary pattern with high dietary inflammatory potential was association with aging acceleration, and the anti-aging potential of DASH-type dietary pattern and “Life’s Simple 7” should also be given attention, but these observations require future prospective validation.
A pathway towards the development and evolution of consumer behavior: Policy directions for sustainable development and improvement of nutrition
Authors: Su Fang , Chang Jiangbo , Zhang Xing , Fahad Shah , Aslam Shimza Bint 
Published: December 2022

IntroductionThe virtuality, concealment, uncertainty and complexity of online trading make the online food trading market have security risks, while the lack of information, information asymmetry and imperfect market system make the “lemon problem” in the market increasingly obvious.MethodsIn order to clearly understand and manage the “lemon problem” in the online food trading market, we built an evolutionary game model involving the seller, buyers and online food trading platform, deeply analyzed the formation process of the “lemon problem” in the online food trading market, and revealed the influencing factors and effects of each subject’s strategy choice from the perspectives of subsidy, punishment, cost, and benefit.ResultsFindings of this study reveal that: (1) In the online food trading market, the strategy of the seller, buyer and platform will be stable in six situations, and the “lemon problem” will emerge with the development and evolution of the online food trading market. (2) The strategy of each subject in the online food trading market will be affected by variables like cost difference between positive performance and negative performance of the seller, punishment from the buyer with positive participation to the seller with negative performance, subsidy from the platform with positive regulation to the seller with positive performance, etc., and different factors have different influence directions and degrees on the subject strategy. (3) In the online food trading market, cost, punishment, subsidy and benefit have different effects on the subject’s strategy. Among them, cost and cost difference have the most significant impact on the subject’s strategy, followed by punishment and benefit difference, and subsidy and additional benefit have less impact on the subject’s strategy.DiscussionBased on our study findings, it is proposed that by constructing a complete and standardized system of online food trading market from the aspects of examination and verification institution, reward and punishment institution, and supervision institution, it will be able to provide reference for managing the “lemon problem” in the online food trading market, promoting the sustainable development of the market, and ensuring the safety of online food.
Development and validation a simple scoring system to identify malignant pericardial effusion
Authors: Jin Xiaxia , Hu Lingling , Fang Meidan , Zheng Qiaofei , Yuan Yuan , Lu Guoguang , Li Tao 
Published: December 2022

BackgroundMalignant pericardial effusion (MPE) is a serious complication in patients with advanced malignant tumors, which indicates a poor prognosis. However, its clinical manifestations lack specificity, making it challenging to distinguish MPE from benign pericardial effusion (BPE). The aim of this study was to develop and validate a scoring system based on a nomogram to discriminate MPE from BPE through easy-to-obtain clinical parameters.MethodsIn this study, the patients with pericardial effusion who underwent diagnostic pericardiocentesis in Taizhou Hospital of Zhejiang Province from February 2013 to December 2021 were retrospectively analyzed. The eligible patients were divided into a training group (n = 161) and a validation group (n = 66) according to the admission time. The nomogram model was established using the meaningful indicators screened by the least absolute shrinkage and selection operator (LASSO) and multivariate logistic regression. Then, a new scoring system was constructed based on this nomogram model.ResultsThe new scoring system included loss of weight (3 points), no fever (4 points), mediastinal lymph node enlargement (2 points), pleural effusion (6 points), effusion adenosine deaminase (ADA≦18U/L) (5 points), effusion lactate dehydrogenase (LDH&gt;1033U/L) (7 points), and effusion carcinoembryonic antigen (CEA&gt;4.9g/mL) (10 points). With the optimal cut-off value was 16 points, the area under the curve (AUC), specificity, sensitivity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (PLR), negative likelihood ratio (NLR) for identifying MPE were 0.974, 95.1%, 91.0%, 85.6%, 96.8%, 10.56 and 0.05, respectively, in the training set and 0.950, 83.3%, 95.2%, 90.9%, 90.9%, 17.50, and 0.18, respectively, in the validation set. The scoring system also showed good diagnostic accuracy in differentiating MPE caused by lung cancer from tuberculous pericardial effusion (TPE) and MPE including atypical cell from BPE.ConclusionThe new scoring system based on seven easily available variables has good diagnostic value in distinguishing MPE from BPE.
Assessment of PD-L1 mRNA expression in gastrointestinal tumors and the response to immunotherapy
Authors: Qiu Qingqing , Li Jieyi , Chen Qiaofeng , Zhao Xiaokai , Zhou Ru , Zhang Wenpeng , Gong Ziying , Zhang Daoyun , Wang Mingliang 
Published: December 2022

BackgroundProgrammed death ligand 1 (PD-L1) immunohistochemistry (IHC) has been proposed as a predictive biomarker to predict response to immunotherapy. Given the limitations of IHC test in PD-L1 detection, this study aimed to investigate the technical feasibility of using quantitative RT-PCR (qRT-PCR) to replace IHC in PD-L1 detection in gastrointestinal tumors.Materials and methodsThe Cancer Genome Atlas database was used to evaluate the relationship between PD-L1 expression in tumor tissue and the patient prognosis. In addition, 52 patients with gastrointestinal cancer were enrolled and divided into the stomach (STAD), colon (COAD), and rectum (READ) adenocarcinoma cohorts. IHC test was used to determine the PD-L1 level of the tissue specimens, and the qRT-PCR test was used to analyze the mRNA expression in both blood and tissue specimens. Moreover, the correlation between blood PD-L1 mRNA expression and immunotherapy efficacy was investigated in additional 15 patients with gastric cancer that further enrolled.ResultsThe expression level of PD-L1 in tumor tissue is related to the tumor stage of COAD (p-value = 0.001) and primary therapy outcomes in patients with READ (p-value = 0.003) but not significantly correlated to the overall survival (OS) time of patients with gastrointestinal cancer. Moreover, the concordance of PD-L1 mRNA expression level of tissue and paired blood samples is low, despite a weak linear relationship that was found in the STAD cohort (r = 0.43, p-value = 0.049). We further demonstrated that qRT-PCR results in both tissue and blood specimens were numerically but not statistically significant consistent with IHC results (corresponding to a p-value of 0.84 and 0.55, respectively). Remarkably, high PD-L1 expression in blood of patients with STAD shows a better response to immunotherapy (p-value = 0.04), which could be well identified at the relative expression cutoff of 1.5 (sensitivity of 85.7%, specificity of 75.0%, and AUC of 0.82).ConclusionsOur study established a novel strategy for rapidly distinguishing patients with gastrointestinal cancer with the response to immunotherapy and has potential clinical benefits.
Accuracy and image quality of wide-detector revolution CT angiography combined with prospective ECG-triggered CT angiography in the diagnosis of congenital aortic arch anomalies in Chinese children
Authors: Xiao Hui-Jun , Zhan A-Lai , Huang Qing-Wen , Huang Rui-Gang , Lin Wei-Hua 
Published: December 2022

ObjectiveTo explore the accuracy and image quality of wide-detector revolution CT angiography combined with prospective ECG-triggered CT angiography in the diagnosis of congenital aortic arch anomalies in Chinese children.MethodsFrom January 2020 to July 2022, the clinical data of 57 children with congenital aortic arch anomalies confirmed by surgery were collected. All patients underwent CT angiography (CTA) with Revolution CT and transthoracic echocardiography (TTE) before the operation. The accuracy of CTA and TTE in the diagnosis of aortic arch anomalies was compared with the surgical results.ResultThe diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of CTA and TTE for congenital aortic arch anomalies (including intracardiac and extracardiac structural abnormalities) were 92.2% and 85.5%, 99.4%, and 99.1%, 97.4% and 95.6%, 98.1% and 96.9%, and 97.2% and 95.2%, respectively. Regarding extracardiac structural malformations, the sensitivity of CTA was 100%, whereas that of TTE was 78.6% (P &lt; 0.001). Regarding intracardiac structural malformations, the sensitivity of CTA was 84.5%, whereas that of TTE was 92.5% (P &lt; 0.001). Regarding satisfaction with the images in aortic arch anomalies, surgeons noted that the CTA images were more useful for diagnosis and operation planning compared with TTE.ConclusionWide-detector revolution CT angiography combined with prospective ECG triggering can be routinely used to assess congenital aortic arch anomalies, providing adequate image quality and high diagnostic accuracy. However, limitations in the identification of intracardiac structural abnormalities are noted.
Splenic rupture and fungal endocarditis in a pediatric patient with invasive fusariosis after allogeneic hematopoietic stem cell transplantation for aplastic anemia: A case report
Authors: Hannemann Maurice , Wilmes Dunja , Dombrowski Frank , Löffler Jürgen , Kaminski Alexander , Hummel Astrid , Ulm Lena , Bohnert Jürgen , Rickerts Volker , Springer Jan , Lode Holger N. , Ehlert Karoline 
Published: December 2022

BackgroundInvasive mold infections are a well-known and life-threatening condition after allogeneic hematopoietic stem cell transplantation (HSCT). While Aspergillus species are recognized as predominant pathogens, Fusarium species should also be considered due to their broad environmental distribution and the expected poor outcome of invasive fusariosis. Particularly, splenic rupture as a complication of disseminated disease has not been reported yet.Case presentationTwo weeks after allogeneic HSCT for severe aplastic anemia, a 16-year-old boy presented with painful, erythematous skin nodules affecting the entire integument. As disseminated mycosis was considered, treatment with liposomal amphotericin B and voriconazole (VCZ) was initiated. Invasive fusariosis was diagnosed after histological and previously unpublished polymerase chain reaction-based examination of skin biopsies. Microbiological tests revealed Fusarium solani species. Despite stable neutrophil engraftment and uninterrupted treatment with VCZ, he developed mold disease-associated splenic rupture with hypovolemic shock and fungal endocarditis. The latter induced a cardiac thrombus and subsequent embolic cerebral infarctions with unilateral hemiparesis. Following cardiac surgery, the patient did not regain consciousness because of diffuse cerebral ischemia, and he died on day +92 after HSCT.ConclusionInvasive fusariosis in immunocompromised patients is a life-threatening condition. Despite antimycotic treatment adapted to antifungal susceptibility testing, the patient reported here developed uncommon manifestations such as splenic rupture and fungal endocarditis.
Measurements on the external load acting on aquatic resistance fins during flexion/extension movements using a robotic joint
Authors: Gislason M. K. , Einarsson I. T. , Ingvason S. S. , Saavedra J. M , Waller B. 
Published: December 2022

Aquatic resistance training has been proven to be beneficial to many people, in particular those struggling with degenerative joint diseases or recovering from other musculoskeletal issues as the reaction forces acting on the joints become lower, but without compromising the cardiovascular and neuromuscular benefit of the movement. Little has been written on the load produced by or measurements of the devices used in aquatic resistance training. Therefore, uncertainties exist regarding details of how much load can be applied onto the foot when performing the movements and how to quantify progression. In this study, an instrumented robotic arm was designed, built, and used to measure the load acting on the three different types of fins during a simulated flexion/extension movement of a knee. The angular velocities of the knee ranged from 25°/s to 150°/s, which represent the physiological range of in vivo movements. The results demonstrated that the load followed a second-order polynomial with the angular velocities. The load is therefore a function of the angular velocity, the surface area of the fins, and the location of the fins away from the joint center rotation. We modeled the progression of speeds at maximal voluntary movements based on previous studies. The maximum loads measured between 11 kg and 13 kg in extension and 6 kg and 9 kg in flexion at 150°/s rotational velocity.
Resting and exercise metabolic characteristics in obese children with insulin resistance
Authors: Youxiang Cao , Lin Zhu , Zekai Chen , Weijun Xie 
Published: December 2022

Purpose: This study aimed to explore the characteristics of resting energy expenditure (REE) and lipid metabolism during incremental load exercise in obese children and adolescents with insulin resistance (IR) to provide evidence for exercise intervention in obese children and adolescents with IR.Method: From July 2019 to August 2021, 195 obese children and adolescents aged 13–17 were recruited through a summer camp. The participants were divided into IR (n = 67) and no-IR (without insulin resistance, n = 128) groups and underwent morphology, blood indicators, body composition, and resting energy consumption gas metabolism tests. Thirty participants each were randomly selected from the IR and no-IR groups to carry out the incremental treadmill test.Results: Significant metabolic differences in resting and exercise duration were found between the IR and no-IR groups. In the resting state, the resting metabolic equivalents (4.33 ± 0.94 ml/min/kg vs. 3.91 ± 0.73 ml/min/kg, p = 0.001) and REE (2464.03 ± 462.29 kcal/d vs. 2143.88 ± 380.07 kcal/d, p &lt; 0.001) in the IR group were significantly higher than in the no-IR group. During exercise, the absolute maximal fat oxidation (0.33 ± 0.07 g/min vs. 0.36 ± 0.09 g/min, p = 0.002) in the IR group was significantly lower than in the no-IR group; maximal fat oxidation intensity (130.9 ± 8.9 bpm vs. 139.9 ± 7.4 bpm, p = 0.040) was significantly lower in the IR group.Conclusion: Significant resting and exercise metabolic differences were found between obese IR and no-IR children and adolescents. Obese IR children and adolescents have higher REE and lower maximal fat oxidation intensity than obese no-IR children and adolescents.
The effects of psychological distance on spontaneous justice inferences: A construal level theory perspective
Authors: Zhang Qing , Wei Wei , Li Ningchen , Cao Wen 
Published: December 2022

ObjectiveThe aim of this study was to examine the effects of psychological distance on spontaneous justice inferences.MethodsTwo experiments were conducted using the probe recognition paradigm to directly examine whether psychological distance affects spontaneous justice inferences. In Experiment 1, the spatial distance of justice actions from the perceivers was manipulated. In Experiment 2, temporal distance was manipulated.ResultsConsistent with our expectations, the results of Experiments 1 and 2 (for spatial distance and temporal distance, respectively) consistently demonstrated the effect of psychological distance on spontaneous justice inferences. In concrete terms, participants made stronger spontaneous justice inferences when confronted with situation descriptions of justice-implying events occurring in a spatially distant location than in a proximal location (Experiment 1) and in the distant-future condition than in the near-future condition (Experiment 2).ConclusionThese findings indicate that psychological distance can influence influence simplicity, unintentional processing of justice inferences.