bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-Hepatitis C Activity of Combination of Ruta angustifolia Extract and Ribavirin
Authors: Wahyuni Tutik Sri , Permatasari Adita Ayu , Aoki-Utsubo Chie , Widyawaruyanti Aty , Fuad Achmad 
Published: September 2022

Background: Hepatitis c virus infection is a global health problem which chronically infected 71 million people in the world. This infection has a risk of becoming liver cirrhosis and hepatocellular carcinoma. Since the current HCV therapy has been developed by direct-acting antivirals (DAA), however, most patients get limited access due to the high cost. Therefore, further development anti-HCV agent still greatly needed. Ruta angustifolia is a natural resource which was reported to possess anti-HCV activity. Ribavirin is an antiviral agent used to treat several virus infections, either DNA or RNA. Ribavirin was known to inhibit HCV infection by regulated immune system in host cells and interfering the replication of HCV by inhibit HCV RdRp. Objective: The current study evaluated the combination treatment of R. angustifolia extracts and ribavirin by in vitro culture cells of Huh 7it. Method: The study was conducted under an invitro cell culture of Huh 7it and infected with JFH1a. Result: The result demonstrated an enhancement effect of the extract by increasing the anti-HCV activity 3.5-fold higher compared to ribavirin alone. The 50% inhibitory concentration of ribavirin by single treatment was 10.43 ± 0.18 µg/mL, while in combination with Ruta angustifolia extract was 2.80 ± 0.03 µg/mL. Further analysis of the combination by CompuSyn software mediated a synergistic effect among the combination with a combination index value of 0.691. Conclusion: These results suggested that combination of Ribavirin and Ruta angustifolia should be considered in developing anti-hepatitis C virus agents.
Health impacts of water and sanitation insecurity in the Global North: a scoping literature review for U.S. colonias on the Mexico border
Authors: Zheng Madeleine , Wutich Amber , Brewis Alexandra , Kavouras Stavros 
Published: September 2022

Abstract
U.S. border colonias are peri-urban settlements along the U.S.–Mexico border. Residents often face substandard housing, inadequate septic and sewer systems, and unsafe or inadequate household water. As of 2015, an estimated 30% of over 5 million U.S. colonia residents lacked access to clean drinking water, suggesting health complications. This scoping review identifies a very limited existing set of research on water and sanitation insecurity in U.S.–Mexico border colonias, and suggests value in additional focused research in this specific context to address health challenges. Preliminary health data indicates that due to water insecurity, colonia residents are more likely to contract gastrointestinal diseases, be exposed to carcinogenic compounds from contaminated water, and experience psychosocial distress. These widespread health issues in colonias are exacerbated by historical and ongoing socioenvironmental injustices in the U.S.–Mexico border region and their relation to the poor health outcomes.
Effects of antimicrobials in anammox mediated systems: critical review
Authors: Zungu Phumza Vuyokazi , Kosgey Kiprotich , Kumari Sheena , Bux Faizal 
Published: September 2022

Abstract
Anammox-mediated systems are thought to be cost-effective and efficient technologies for removing nitrogen from wastewater by converting nitrite and ammonium into dinitrogen gas. However, there are inhibitory substances that reduce the effectiveness and efficiency of these processes, preventing their widespread application. Antimicrobial agents are among these substances that have been observed to inhibit anammox-mediated processes. Therefore, this review provides a comprehensive overview of the effects of various antimicrobials on the anammox-based systems with emphasis on the effects in different reactor configurations, sludge types and microbial population of anammox-based systems. In addition, this review also discusses the mechanisms by which nitrifying bacteria are inhibited by the antimicrobials. Gaps in knowledge based on this review as well as future research needs have also been suggested. This review gives a better knowledge of antimicrobial effects on anammox-based systems and provides some guidance on the type of system to use to treat antimicrobial-containing wastewater using anammox-based processes.
Phytochemicals-based Therapeutics against Alzheimer's Disease: An Update
Authors: Ayaz Muhammad , Nawaz Asif , Naz Falak , Ullah Farhat , Sadiq Abdul , Islam Zia Ul 
Published: September 2022

Abstract:
Alzheimer’s disease (AD) is one of the main healthcare challenges of the twenty-first century, not only affecting millions people's quality of life but also increasing the burden on the medical community, families and society. It is a neurodegenerative disorder characterized by learning and cognitive dysfunction, behavioral turbulence, and memory loss and is a major cause of dementia, contributing to 50–60 % of dementia cases in patients above the age of 65. The major pathophysiological changes include accumulation of beta-amyloid plaques (Aβ), highly phosphorylated tau protein, neuroinflammation, GABA neurotransmission disruption, mitochondrial dysfunction, neuronal damage due to free radicals, and decrease in the concentration of acetylcholine (ACh) and butyrylcholine (BCh). The inability of commercial therapeutics such as donepezil, rivastigmine, galantamine, and tacrine leads to the attraction towards phytochemical based therapeutics. Phytochemicals derived from plants exhibit neuroprotection via targeting apoptosis, neurotrophic factor deficit, mitochondrial dysfunction, oxidative stress, and abnormal accumulation of proteins. Here we discussed some of the neuroprotective phytochemicals used for the treatment of neurodegenerative diseases like AD and dementia.
Self-management Strategies for Patients with Risk Factors to Reduce the Impact of Cardiovascular Disease in Selected Clinics in Limpopo Province, South Africa
Authors: Kgatla Mamoeng Nancy , Mothiba Tebogo Maria , Malema Rambelani Nancy , Makgahlela Mpsanyana , Sodi Tholene 
Published: September 2022

Background:
Cardiovascular diseases are now the leading cause of death worldwide, amounting to 17.8% of all deaths recorded. In Sub-Saharan Africa, it contributes to about 13% of deaths, whereas 80% were recorded from developing countries. A quarter of all deaths are attributable to behavioural and metabolic risk factors due to patients` lack of self-management strategies, which are practices and activities that the patients can use and manage themselves, effectively preventing the development of CVD.

Objective:
The study aimed to explore patients at risk of CVD’s knowledge of self-management strategies to prevent the development of CVD.

Methods:
This was a qualitative exploratory and descriptive study conducted in four primary health care settings in two contexts (i.e., a rural and peri-urban setting) in the Capricorn District of Limpopo Province, South Africa. The target population were patients with risk factors and diagnosed with either hypertension or diabetes mellitus. Twenty-five patients (male n=9; female n=16) were purposefully sampled and participated in semi-structured individual interviews with a schedule guide. The data was analysed using thematic Tesch’s open coding qualitative data analysis method.

Results:
Thematically analysed data resulted in three main themes and their related subthemes enumerating patients at risk of CVD’s knowledge regarding disease onset, risk factors, and self-management, including daily challenges affecting disease progression. The major themes isolated are 1) knowledge related to CVD onset, symptoms, and self-management strategies, 2) challenges experienced by persons at risk of developing CVD, 3) suggestions to help improve health and the prevention of the onset of CVD.

Conclusion:
The study concludes by recommending in-depth CVD awareness and education programs for patients at risk. More importantly, the provision of mental health awareness, counselling, and equipping patients with coping skills are recommended.
Collective Action for Wellness in the Malaysian Workplace: Protocol for a Feasibility Study
Authors: Thai Janus Y , McCaffrey Tracy , Ramadas Amutha , Chandrasekara Dharshani , Koh Sharon G M , Choi Tammie Suet Ting , Malini Hema , Xie Jue , Olivier Patrick , Md Zain Anuar Zaini , Watterson Jessica 
Published: September 2022

Background
Chronic diseases and the associated risk factors are preventable with lifestyle changes such as eating a healthier diet and being more physically active. In Malaysia, the prevalence of chronic diseases, including diabetes, hypertension, and heart diseases, has risen. In the present study, we explore the potential of co-designing and implementing a digital wellness intervention to promote socially-driven health knowledge and practices in the workplace in Malaysia, drawing on social cognitive theory, social impact theory, and social influence theory.

Objective
This study aims to co-design and assess the feasibility of a socially-driven digital health intervention to promote healthy behavior and prevent chronic diseases in a workplace in Malaysia.

Methods
This study involves two phases: (i) identifying the barriers and facilitators to healthy behaviors at work and co-designing the intervention activities with the employees, (ii) implementing and evaluating the intervention’s feasibility. Phase 1 will involve qualitative data collection and analysis through semi-structured, in-depth interviews and co-design workshops with the employees, while Phase 2 will consist of a feasibility study employing quantitative measurements of health behaviors through accelerometers and questionnaires.

Results
This study was funded in June 2021 and ethics approval for Phase 1 was obtained from the Monash University Human Research Ethics Committee in January 2022. As of August 2022, qualitative interviews with 12 employees have been completed and the data has been transcribed and analyzed. These results will be published in a future paper with results from all Phase 1 activities.

Conclusions
The study will help us to better understand the mechanisms through which digital technologies can promote socially-driven health knowledge and behaviors. This research will also result in a scalable wellness intervention that could be further tailored and expanded to other employers and social groups across the region.

International Registered Report Identifier (IRRID)
PRR1-10.2196/39238
Augmentation of Nanofluids Heat transfer in a Circular Tube with Baffled Winged Twisted Swirl Generator
Authors: Salman Sami D. , Abd Alsaheb Ramzi Ata 
Published: September 2022

This article introduces a numerical study on heat exchange and corrosion coefficients of Zinc–water nanofluid stream in a circular tube fitted with swirl generator utilizing CFD emulation. Different forms of swirl generator which have the following properties of plain twisted tape (PTT) and baffle wings twisted tape (BTT) embeds with various ratio of twisting (y = 2.93, 3.91 and 4.89), baffle inclination angles (β = 0°, - 30° and 30) joined with 1%, 1.5% and 2% volume fraction of ZnO nanofluid were utilized for simulation. The results demonstrated that the heat and friction coefficients conducted by these two forms of vortex generator raised with Reynolds number, twist ratio and baffle inclination angles decreases. Likewise, the results showed that the heat transfer rate raised with accretion of ZnO nanoparticle concentration. Furthermore, the maximum rate of heat transfer with significant intension in friction coefficient has been produced by baffle wings tape with ratio of twisting y=2.93 and baffle angle β= -30 with 2% volume fraction of ZnO nanofluid.
Online three-tier diagnostic test to identify misconception about virus and COVID-19
Authors: Fikri Refsya Aulia , Suwono Hadi , Susilo Herawati 
Published: September 2022

During the COVID-19 pandemic, various misinformation circulating among the public has the potential to be a source of misconceptions. This study aimed to validate the online three-tier diagnostic instrument test for Virus and COVID-19 as well as analyze the level of misconceptions experienced by students. The Treagust model is used as a reference for the instrument development process. Three public high schools providing 187 second grade students who had previously studied Virus content were involved as research respondents, The data analysis techniques used were descriptive statistics. Construct and content validity obtained from expert validation reached 89.88% and 97.12%, respectively. The results of data analysis also inform that each item was valid and the instrument was reliable. The average percentage of students who experience misconceptions was 39.96%. The average percentage of students who understand the topic correctly was 32.10%. The percentage of lucky guess reached 14.83% and students with low level of knowledge reached 13.10%. The diagnostic test as overall, was successful in detecting students’ misconceptions. To overcome misconceptions and improve the quality of learning during a pandemic, biology learning must apply creative learning models, methodologies, and teaching materials.
Perbandingan Antara Metode USLE dan MUSLE Dalam Analisis Erosi Lahan Pada Daerah Tangkapan Air Waduk Cengklik
Authors: Abdurrosyid Jaji , Saputra Krisna Dwi Aji 
Published: September 2022

Waduk Cengklik adalah waduk yang terletak di Desa Ngargorejo, Kecamatan Ngemplak, Kabupaten Boyolali, Provinsi Jawa Tengah. Waduk Cengklik sendiri memiliki fungsi utama sebagai pemasok air irigasi pada 3 kecamatan yaitu Sambi, Ngemplak, dan Nogosari. Oleh karena setiap tahunnya waduk cengklik mengalami penurunan tampungan air menyebabkan kurangnya pasokan air ke pertanian di 3 kecamatan terutama saat musim kemarau. Hal ini disebabkan oleh besarnya laju sedimentasi yang terjadi. Penelitian ini bertujuan untuk menghitung laju sedimentasinya yang nantinya bisa dilakukan penangan agar sedimentasi di waduk bisa berkurang dan tampungan air pada waduk tidak berkurang. Prediksi erosi dan laju sedimentasi pada penelitian ini menggunakan 2 metode yaitu USLE (Universal Soil Loss Equation) dan MUSLE (Modified Universal Soil Loss Equation). Dari hasil penelitian ini diperoleh nilai faktor erosifitas hujan (R) dari tahun 2010-2019, faktor erodibilitas tanah (K) sebesar 0,23, faktor panjang dan kemiringan lereng (LS) sebesar 0,4, faktor tanaman penutup lahan dan faktor tindakan konservasi (CP) sebesar 0,491 sehingga didapatkan besar erosi dan laju sedimentasi menggunakan Metode USLE sebesar 66,698 ton/ha/tahun dan 14,653 ton/ha/tahun. Lalu diperoleh nilai debit banjir maksimum (QP), volume aliran permukaan (VQ) dan limpasan permukaan (R) tahun 2010-2019 sehingga erosi dan laju sedimentasi menggunakan Metode MUSLE sebesar 35,106 ton/ha/tahun dan 7,713 ton/ha/tahun. Kemudian didapatkan rasio pembadingan antara Metode USLE dan MUSLE sebesar 1,90 : 1,00.
La quasi vida de la percepción artificial
Authors: Fryga Verónica 
Published: September 2022

Elsa Boyer desarrolla un intricado análisis de la fenomenología husserliana desembocando en un examen local sobre la conciencia de imagen libre o Phantasia inducida por los videojuegos y dispositivos de realidad virtual contemporáneos.
A partir de la experiencia que provoca el contacto con lo virtual y los bagajes perceptivos que allí se activan involucrando lo kinestésico, táctil, sonoro, recuerdos y simulacros; indaga sobre la relación entre soporte técnico, imaginación y percepción ampliando las fronteras del campo fenomenológico. Su obra nos interpela preguntándonos ¿existe una esencia de la percepción artificial? de ser así, ¿cuál es? y ¿qué conflictos inaugura?
The impact of foliar application of biostimulators on the morphological characteristics of the leaf rosette of winter rape plants
Authors: Sikorska Anna , Gugała Marek , Zarzecka Krystyna , Domański Łukasz 
Published: September 2022

The field experiment was caried out in three growing seasons (2013–2016) at the Agricultural Experimental Station – Zawady (52°03'N and 22°33'E) belonging to the University of Natural Sciences and Humanities in Siedlce, Poland. The experiment was set up in a split-plot configuration with three replications. The examined factors were: I – morphotypes of winter oilseed rape: population (Poznaniak), hybrid restored with a semi-dwarf type of growth (PX104), hybrid restored with a traditional type of growth (Konkret); II – four types of biostimulators: 1. control variant, 2. biostimulator Tytanit® (titan), 3. biostimulator Asahi®SL (sodium ortho-nitrophenol, sodium para-nitrophenol, sodium 5-nitroguaiacol), 4. biostimulator Silvit® (active silicon, potassium oxide, boron – form of pure element, zinc – form of pure element). The aim of the study was to evaluate the effect of biostimulators containing various active substances on the morphological characteristics of winter oilseed rape plants in the leaf rosette stage (number of rosette leaves, tap root length, height of the growth cone) and on the fresh and dry mass of the above-ground rosette and the root system of traditional and semi-dwarf winter oilseed rape morphotypes type of growth under changing climatic conditions. The genetic factor significantly influenced the morphological features of plants, marked in autumn by inhibition of vegetation. The population variety Poznaniak developed more rosette leaves, greater length of the tap root, and fresh and dry mass of the rosette and the root system as compared to the restored hybrids. The applied biostimulators significantly influenced plant parameters determined in the fall before the vegetation inhibition. After the use of a biostimulator containing the active substance in the form of sodium o-nitrophenol, sodium para-nitrophenol and sodium 5-nitroguajakol, a significantly higher value of the tested features was obtained compared to the control variant. Regardless of the type of biostimulator used, the height of the growth cone was the same as in the control object. The most favourable parameters of the leaf rosette were obtained in the first and second periods of summer-autumn vegetation and winter dormancy, while in extreme drought conditions during sowing and a fairy dry period of emergence, its weakest features were obtained. Natural growth stimulants are becoming an increasingly common elements of agricultural plant agrotechnics. Their use has a positive effect on the growth and development of plants and increases the resistance of plants to the adverse effects of stress factors.
From Incubation to Sustainability: a Case-Study of Graduated Companies in Portugal
Authors: Almeida Cunha Alegre Silva Maria Teresa , Clara Ribeiro Parente Cristina 
Published: September 2022

The purpose of this article is to discuss business incubators as a new way to boost companies and create jobs in a very competitive economic context. From a sociological perspective inspired by concepts such as those of “network” and “social capital”, we analyse the entrepreneurial ecosystem as an instrument to overcome challenges during post-incubation. A qualitative research based on a multiple case-study in companies formerly incubated at the Science and Technology Park of the University of Porto (UPTEC) was conducted to analyse the impact of incubation on graduation and growth. The research objective was to understand the importance of business incubators for business sustainability. Our findings show that companies from the UPTEC were strengthened during incubation, particularly as a result of available low cost services and the reproduction of their networking context through the implementation of business communities after incubation.
The Approach to Fire Safety in the Curriculum Map-Matrix of Engineering Courses at a Federal University According to The Parameters of law 13.425: a Systematic Review
Authors: Silva Priscilla Chantal Duarte , Chaves Ferreira Stefania , Tomich Magalhães Felippe Anna Rita , Perez Teixeira Ricardo Luiz 
Published: September 2022

Objective: the aim of this study is to analyze how and how often the fire protection approach is included in the curriculum of engineering courses.

Theoretical reference: fire protection has gained the spotlight, in large part, as a result of some disasters that have occurred in recent years. The subject has evolved and gained considerable prominence, thus requiring changes in current legislation, as well as the formulation of new Standards and Laws, capable of mitigating the risk of fire occurrence. It is necessary to understand the role of the future engineer on the fire protection policy, to avoid possible fire occurrences in institutions. So, several studies from literature about fire have been used to a theorical basis of this research.

Methodology: a systematic literature review whit Prism protocol have been used to a review literature. The databases used and selected for this study was Google Academic, Scielo and Eric was carried out in a quantitative analysis. Secondly, in a qualitative analysis, a case study was carried out, starting with an investigation of the curriculum of nine engineering courses at a Brazilian university, to verify the consistency of the fire protection approach and compliance with the “Kiss Law” in the courses studied.

Results and conclusion: the results indicate a certain insufficiency of disciplines when analyzing the curricular matrices of each course. In most cases, the adoption of contents or disciplines that address the topic present fire protection generically and inconsistently. It is concluded that there is still a lack of knowledge about the relevance of the topic and effective non-compliance with legislation on the subject. There is, therefore, a need for implementation measures in the learning topics of engineering curricula.

Originality/ value: There are few studies on fire protection in the school environment. So, the originality of this study is in analyzing how engineering schools are implementing fire protection legislation and how this practice is effective for collective safety.
"The Perspective of Waste Pickers on Their Work: Incentives and Challenges in a City in a Developing Country"
Authors: De Oliveira Suellen Araújo , Ribeiro Ana Regina Bezerra , Sobral Marcos Felipe Falcão 
Published: September 2022

Objective: The present research aimed to identify, from the perspective of the collectors of recyclable materials, the challenges and incentives of performing their work in a city of a developing country.

Introduction: Waste generation is expected to grow significantly by 2050 in developing countries, making them the largest generators of MSW in the world. The Circular Economy is reflected as an alternative for dealing with the waste issue, since it seeks to promote the reduction of waste generation. For developing countries, the collectors of recyclable materials are important players in reinserting the materials into the production cycle. Brazil is an important player in this scenario, since it ranks among the five largest SUW generators in the world and has waste pickers as the majority responsible for waste recycling in the country.

Methodology: Semi-structured interviews were conducted with 67 of the 125 organized waste pickers recognized by the city government, whose answers were categorized and analyzed qualitatively with quantitative contribution coming from the correlation in three stages: incentives, challenges, and incentives and challenges.

Results and Conclusion: The study concluded that, for the Brazilian city collectors, the main stimulus for carrying out their professional activities is income generation, followed by collaboration to cause a positive impact on the environment. And, as the main challenge, the non-separation followed by the inadequate disposal of waste, which compromises the quality of the materials and the collectors' health.