bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gambaran Kadar Debu Respirabel pada Pekerja Bagian Produksi di PT. Bintang Manunggal Persada Kelurahan Buluri Kota Palu
Authors: Sunuh Herlina , Subagyo Indro 
Published: October 2022

Pendahuluan: Debu merupakan salah satu partikel yang melayang di udara. Pada peristiwa polusi udara baik di dalam maupun udara ambien (Indoor and Out Door Pollution) Debu merupakan parameter yang dijadikan sebagai salah satu indikator pencemaran yang menyatakan tingkat bahaya baik bagi lingkungan maupun terhadap kesehatan dan keselamatan kerja. Tujuan: Penelitian ini bertujuan untuk memberikan gambaran kadar debu respirabel pada pekerja di bagian produksi PT. Bintang Manunggal Persada Kelurahan Buluri. Metode: Penelitian ini merupakan jenis penelitian deskriptif dengan pendekatan observasional, dari populasi yaitu 26 orang responden bagian produksi dengan jumlah sampel sebesar 5 orang yang pengambilannya dilakukan menggunakan Kriteria inklusi yaitu mereka yang bersedia dijadikan sebagai responden. Hasil: Hasil penelitian menunjukkan bahwa dari pengukuran kadar debu pada pekerja bagian produksi di PT. Bintang Manunggal Persada dengan menggunakan Personal Dust Sampler, menunjukkan bahwa 4 responden memenuhi persyaratan dan 1 responden tidak memenuhi persyaratan karena hasil pengukuran yang menunjukkan, jumlah kadar debu yang masuk melalui zona pernapasan melebihi NAB 3,0mg/m3. Kesimpulan: Berdasarkan hasil analisa disimpulkan bahwa dari 5 orang responden diperoleh I orang dengan kadar debu respirabel melebihi Nilai Ambang. Debu respirabel memiliki risiko yang cukup tinggi terhadap terjadinya keluhan kesehatan seperti gangguan pernafasan.
Peningkatan Pengetahuan tentang Sanitasi Total Berbasis Masyarakat (STBM) pada Kepala Keluarga di Desa Bale Kecamatan Tanantovea Kabupaten Donggala
Authors: Bungawati Andi 
Published: October 2022

Pendahuluan: Sanitasi menjadi salah satu tujuan pembangunan berkelanjutan SDGs meskipun dilapangan menunjukkan kemajuan yang masih lambat. Strategi Nasional Kebijakan STBM mengacu pada strategi percepatan yang bertujuan untuk mengejar target SDGs. Poster dipilih sebagai media penyuluhan karena ekonomis dan mudah dipahami dan bisa berfungsi sebagai pengingat bagi sasaran. Tujuan: Tujuan penelitian untuk mengetahui efektifitas poster untuk meningkatkan pengetahuan tentang STBM pada kepala keluarga di Desa Bale Kabupaten Donggala. Metode: Jenis penelitian ini adalah metode eksperimen semu dengan pendekatan pre-test and post-test one group design. Sampel dalam peneltian ini adalah 41 responden yang masuk dalam anggota populasi menggunakan teknik sampling random sederhana. Penelitian ini dilaksanakan di Desa Bale Kabupaten Donggala. Hasil: Hasil penelitian dengan menggunakan uji paired sampel t-test didapatkan bahwa skor pengetahuan kepala keluarga sebelum diberikan penyuluhan menggunakan poster, yaitu sebesar 26,82 dan pengetahuan kepala keluarga sesudah diberikan poster yaitu sebesar 31,40. Kesimpulan: Pemberian poster memberikan pengaruh terhadap pengetahuan kepala keluarga mengenai STBM karena nilai p-value yang didapatkan 0,000 < 0,05.
Does the sizing of current cervical disc arthroplasty systems match Chinese cervical anatomic dimensions?
Authors: Wang Lu , Bai Meng , Li Xing-Bin , Wang Zhao-Rui , Wang Bang , Huang Ai-Bing 
Published: October 2022

Objective: The objectives of this study were to analyze the computed tomography (CT) scan imaging data of the cervical spine from healthy volunteers and to correlate the measurements to the dimensions of current cervical disc arthroplasty systems.Methods: A total of 130 participants (78 males and 52 females) with a mean age of 41.0 years (range 18.0–66.0 years) who had undergone computed tomography scans of the cervical spine were included. The linear parameters of the C3 to C7 levels, including anterior-posterior diameter (AP), middle disc height (DH), anterior disc height (ADH), posterior disc height (PDH) and center mediolateral diameter (ML), were measured. The analysis was conducted comparing different cervical levels, sexes, and age groups. Known dimensions from eight cervical disc arthroplasty systems were compared with the morphologic data.Results: A total of 520 vertebral segments were measured. The mean values for the measured parameters were as follows: anterior-posterior diameter 16.08 ± 1.84 mm, mediolateral diameter 16.13 ± 1.99 mm, anterior disc height 3.88 ± 1.11 mm, disc height 5.73 ± 1.00 mm, posterior disc height 2.83 ± 0.94 mm, and mediolateral diameter/anterior-posterior diameter 1.01 ± 0.13. All parameters except for posterior disc height were significantly different across the different cervical levels (p &lt; 0.05). There were also significant sex differences in terms of the linear parameters. No differences were found in the majority of parameters among the different age groups (p &gt; 0.05), except for anterior-posterior diameter at the C6/7 level. A comparison of the bone dimensions from the study data and the dimensions of the implants indicated the presence of a size mismatch in the currently available cervical disc prostheses.Conclusion: There is a large discrepancy between the cervical anatomical data of Chinese patients and the sizes of currently available prostheses. The dimensions collected in this study could be used to design and develop appropriate disc prostheses for Chinese patients.
First quantitative dosages: Strong correlations between non-5-HT2Rs serotonin receptors on normal human heart valves
Authors: Schussler Olivier , Maroteaux Luc , Jashari Ramadan , Falcoz Pierre , Alifano Marco , Lecarpentier Yves , Launay Jean-Marie 
Published: October 2022

ObjectivesAlthough critical in animal and human development and pathology, a measurement of the quantitative expression of 5-HTR serotonin receptors on animal or human valvular tissues has never been performed.MethodsQuantification of the most frequent 5-HTRs reported as being present in human peripheral tissue was performed using radiolabeled agonists/antagonists. A membrane protein extract from normal human valves (aortic/mitral/tricuspid and some pulmonary) and associated diseased left myocardium, all unusable in clinics, were obtained from the Homograft bank.ResultsWe analyzed 5-HT1AR/5-HT1B/DR/5-HT2AR/5-HT2BR/5-HT 2CR/5-HT4R/5-HT7R from 28 hearts. We confirmed the presence of tissue and measured the quantitative content for respective proteins in femtomol/mg of protein extracts: for 5-HT2AR (35.9+/−0.7), 5-HT2BR (28.8+/−1.3) but also a newly observed and robust expression for 5-HT4R (38+/−4.2). We identified one, 5-HT1ARs (4.9+/−0.3), and the possible expression, but at a very low level, of previously reported 5-HT1B/DRs (1.3+/−0.5) as well as the new 5-HT7Rs (3.5+/0.1) and 5-HT2CRs (1.2+/−0.1). Interestingly, by using univariate analysis, we were able to observe many correlations between the different 5-HTR levels of expression especially between 5-HT1AR/5-HT1B/DR and also between 5-HT4R/5-HT7R, but none were observed between 5-HT2AR and 5-HT2BR. Using multivariate analyses for a specific 5-HTR level of expression, after adjustment for implantation sites and other 5-HTRs, we found that 5-HT1AR was correlated with 5-HT1B/DR;5-HT4R with 5-HT7R and 5-HT1AR;5-HT2BR with 5-HT2AR only. For 5-HT2C, no correlation was observed.Conclusion5-HT2AR/5-HT2BR and 5-HT4R were all observed to have a high and equal level of expression on human valves, but that of 5-HT1AR was more limited. Since these non-5-HT2Rs are coupled with different G-proteins, with specific signaling, theoretically they may control the main 5-HT2R signaling (i.e., PLC/DAG-PKC-ERK/Ras/Src signaling) involved in valvular fibrosis and degeneration.
Similar clinical outcomes with transcatheter aortic valve implantation and surgical aortic valve replacement in octogenarians with aortic stenosis
Authors: Kolar Tadeja , Lakič Nikola , Kotnik Aleša , Štubljar David , Fras Zlatko , Bunc Matjaž 
Published: October 2022

BackgroundTranscatheter aortic valve implantation (TAVI) is the preferred treatment option for severe aortic stenosis in the elderly and in patients with comorbidities. We sought to compare outcomes after TAVI and surgical aortic valve replacement (SAVR) in octogenarians.MethodsIn this retrospective cohort study conducted at our tertiary center, clinical data were gathered before and after TAVI and SAVR procedures performed from January 2013 to May 2019; follow-up completed in March 2021. The primary outcome was 1-year mortality. Patients were stratified according to Society of Thoracic Surgeons (STS) score and procedure type. Propensity score-based matching was also performed.ResultsOf 542 patients who matched the inclusion criteria, 273 underwent TAVI and 269 SAVR. TAVI patients were older (85.8 ± 3.0 vs. 82.2 ± 2.2 years; P &lt; 0.001) and had a higher mean STS score (5.0 ± 4.0 vs. 2.8 ± 1.3; P &lt; 0.001) and EuroSCORE II (5.3 ± 4.1 vs. 2.8 ± 6.0; P &lt; 0.001). Rates of postoperative permanent pacemaker insertion (15.0% vs. 9.3%; P = 0.040) and paravalvular leak (9.9% vs. 0.8%; P &lt; 0.001) were higher and acute kidney injury lower (8.8% vs. 32.7%; P &lt; 0.001) after TAVI, with no difference between treatment groups for major bleeding (11.0% vs. 6.7%; P = 0.130) or 30-day mortality (5.5% vs. 3.7%; P = 0.315). A statistically significant difference was found between TAVI and SAVR in low- and intermediate-risk groups when it came to occurrence of paravalvular leak, acute kidney injury, and new onset AF (all P &lt; 0.001).ConclusionThis analysis of an octogenarian “real-life” population undergoing TAVI or SAVR (with a biological valve) showed similar outcomes regarding clinical endpoints in low- and medium-risk (STS score) groups.
Wheat straw biochar and its performance in treatment of phenanthrene containing water and microbial remediation of phenanthrene contaminated soil
Authors: Ding Chengcheng , Gan Yonghai , Luo Jun , Cui Yibin 
Published: October 2022

In recent years, biochar has been considered as an effective adsorbent and soil conditioner due to its abundant carbon and high porosity. This study applied a kind of biochar from wheat straw pyrolysis to remediate phenanthrene-contaminated water and soil. The performance of the biochar in the removal of phenanthrene was discussed by liquid phase adsorption and soil incubation experiments. Furthermore, this work explored the enhancement effect of wheat straw biochar on soil microbial numbers and soil properties. The result of liquid phase adsorption indicated, 92.2% of phenanthrene was removed after incubating 0.6 g/L of wheat straw biochar for 4 h. Pseudo-second-order kinetic model (R2 = 0.99823) and Langmuir isotherm model (R2 = 0.99577) described the removal of phenanthrene by wheat straw biochar well. In soil incubation experiment with an initial phenanthrene content of 11.2 mg/kg, 89.1% of phenanthrene was removed at biochar dosage of 12% (w/w, wheat straw biochar/soil) after 30 days of incubation. In addition, the number of soil microorganisms, soil pH and organic matter (SOM) content increased after wheat straw biochar treatment. At the dosage of 12%, soil microbial count increased to 9.8 × 108 CFU/g-soil, soil pH increased by 1.8 units and SOM increased by 8.5 folds. The addition of wheat straw biochar not only improved soil quality, but also reduced the proportion of phenanthrene components, which could provide theoretical support for the resource utilization of agricultural waste.
Participant characteristics associated with the effects of a physical and cognitive training program on executive functions
Authors: Tirkkonen Anna , Törmäkangas Timo , Kulmala Jenni , Hänninen Tuomo , Neely Anna Stigsdotter , Sipilä Sarianna 
Published: October 2022

BackgroundPhysical and cognitive interventions have been shown to induce positive effects on older adults’ executive functioning. However, since participants with different background characteristics may respond differently to such interventions, we investigated whether training effects on executive functions were associated with sex, training compliance, and age. We also investigated if change in global cognition was associated with physical and cognitive training intervention-induced changes in executive functions.MethodsExploratory data from a randomized controlled trial were analyzed. Participants were 70–85-year-old men and women who received a 12-month physical (PT) or physical and cognitive training (PTCT) intervention. Measurements of executive functions related to inhibition (Stroop), set shifting (Trail Making Test B) and updating (Verbal Fluency) were performed at baseline and 12 months. Data were analyzed using a longitudinal linear path model for the two measurements occasion.ResultsStroop improved significantly more in women and participants in the low compliance subgroup who received PTCT than in counterparts in the PT subgroup (difference –8.758, p = 0.001 and difference –8.405, p = 0.010, respectively). In addition, TMT B improved after the intervention in the low compliance PTCT subgroup and worsened in the corresponding PT subgroup (difference –15.034, p = 0.032). No other significant associations were observed.ConclusionExecutive functions in women and in the participants, who only occasionally engaged in training showed greater improvement after the PTCT than PT intervention. However, the additional extra benefit gained from the PTCT intervention was uniquely expressed in each executive function measured in this study.
Fluctuation of depressive symptoms in cognitively unimpaired participants and the risk of mild cognitive impairment 5 years later: Results of the Heinz Nixdorf Recall study
Authors: Jokisch Martha , Schramm Sara , Weimar Christian , Moebus Susanne , Gronewold Janine , Dragano Nico , Jöckel Karl-Heinz 
Published: October 2022

BackgroundDepression might be an independent risk factor for cognitive decline, a prodromal dementia symptom or a reaction to cognitive/functional impairment.ObjectiveTo investigate the association between (1) depressive symptoms and (2) depressive symptom patterns over 13 years with incident mild cognitive impairment (MCI) 5 years later.Materials and methodsWe included 724/823 cognitively unimpaired men/women who participated in the population-based Heinz Nixdorf Recall study (t1: 2005–2008, ø62.9 years; t2: 2010–2015, ø68.1 years). Depressive symptoms were assessed in the study center and during six postal follow-ups using the short form of the Center for Epidemiologic Studies Depression Scale (CES-D). Relative risks (RR; 95% confidence intervals) for MCI at t2 (men/women: 71/76) were estimated for CES-D at t1 (linear and dichotomized at ≥17, cut-off for clinically relevant depressive symptoms) and CES-D fluctuations over 13 years (stable low, large fluctuations, stable high/stable around cut-off) using log-linear regression models with Poisson working likelihood adjusted for age, sex, education, diabetes mellitus, coronary heart disease, and stroke.ResultsFully adjusted risk for MCI at t2 (per CES-D point increase at t1) was elevated for the total cohort (1.053, 1.031–1.076), men (1.046, 1.012–1.081), and women (1.059, 1.029–1.090). Applying the dichotomized CES-D, risk for MCI was substantially increased for the total cohort [2.22 (1.38–3.58)] and in women [2.59 (1.46–4.58)]. Large CES-D fluctuations and stable high/stable around cut-off were associated with increased RR for MCI in the total cohort and in women compared to stable low symptoms.ConclusionDepressive symptoms predicted MCI in cognitively unimpaired participants of our population-based study. Adequate treatment of depression may therefore contribute to the maintenance of normal cognition and delay dementia onset.
Can laparoscopic nerve-sparing ultra-radical hysterectomy play a role in locally advanced cervical cancer? A single-center retrospective study
Authors: Wei Wei-wei , Zheng Hong , Shao Panqiu , Chen Xia , Min Yi-fei , Tang Bin , Sun Hui-ting , Chen Ji-ming , Shi Ru-xia 
Published: October 2022

Background and objectivesThe objective of this study is to investigate the outcomes of concurrent platinum-based chemoradiation therapy (CCRT), laparoscopic nerve-sparing ultra-radical hysterectomy (LNSURH), and open radical hysterectomy (ORH) on patients with locally advanced cervical carcinoma (LACC).MethodsA single-center retrospective study was conducted on LACC patients who received CCRT, ORH, or LNSURH from January 2011 to December 2019. Data on age, tumor size, overall survival (OS), disease-free survival (DFS), and early and late morbidities were collected. After 24 months of treatment, patients were asked a series of questions about their urinary, bowel, and sexual activities. Early morbidities were defined as those occurring during or within a month of treatment, whereas late morbidities and complications were defined as those occurring a month after treatment. The postoperative complications were classified with reference to the Clavien–Dindo classification (CD) system.ResultsThe Kaplan–Meier curves revealed no significant differences in OS and DFS among the three groups (P = 0.106 for DFS and P = 0.190 for OS). The rates of early complications in the CCRT group were comparable with those in the operated groups (P = 0.46). However, late complications were significantly lower in the ORH and LNSURH groups relative to those in the CCRT group. The scores of urinary and bowel functions were restored to the pretreatment state, although the sexual function scores were not satisfactory.ConclusionsThe treatments of CCRT, ORH, and LNSURH can be considered options for patients with LACC, as their OS and DFS showed no significant difference. In addition, LNSURH exhibited a lower incidence of late complications and high sexual function scores.
Anti-arthritic and toxicological evaluation of ethanolic extract of Alternanthera bettzickiana in rats
Authors: Manan Maria , Saleem Uzma , Ahmad Bashir , Aslam Nosheen , Anwar Asifa , Zafar Aimen 
Published: October 2022

In many developing countries, medicinal plants have long been used for therapeutic purposes due to their low cost and toxicity. This study evaluated the safety and anti-arthritic potential of Alternanthera bettzickiana ethanolic extract (ABEE). Acute oral toxicity (OECD 425) was tested in the safety evaluation. A limit test was used to identify the LD50 value. For an acute oral toxicity study a dose of 2000 mg/kg of ABEE was given orally to the treatment group, and the control group received distilled water at a rate of 10 ml/kg. Biochemical, hematological, and histopathological analyses were performed after 14 days. A formaldehyde 2% w/v solution was injected via i.p. to rats of all groups to prepare the arthritic model. Five groups were divided into control (D.H2O), standard (Diclofenac), and three groups receiving the plant extract at dose levels of 125 mg/kg, 250 mg/kg, and 500 mg/kg respectively. Treatment was continued for 10 days. Paw diameter and hematological and biochemical variables were quantified. ELISA was performed for the estimation of inflammatory cytokines. In the acute oral toxicity study, no mortality or morbidity were observed, so the LD50 of this plant was greater than 2000 mg/kg. ABEE decreased the paw diameter with the restoration of hematological and biochemical changes. SOD and CAT levels were increased while decreasing the MDA, NO, TNF-α, and IL-6 levels in arthritic rats. It is concluded that the use of A. bettzickiana has low toxicity, and it can be used for the treatment of arthritis.
A qualitative exploration of the mental health challenges and therapeutic needs of Canadian correctional workers
Authors: Moghimi Elnaz , Knyahnytska Yuliya , Zhu Yiran , Kumar Anchan , Knyahnytski Alexander , Patel Charmy , Omrani Mohsen , Gerritsen Cory , Martin Michael , Simpson Alexander Ian Frederic , Alavi Nazanin 
Published: October 2022

PurposeCorrectional work is described as a high-stress environment associated with increased prevalence of mental health disorders in employees. Identifying appropriate healthcare services necessitates investigating the mental health challenges and needs of correctional workers (CWs).MethodsIndividual interviews (n = 9; 5 M and 4 W) and a mixed gender focus group (n = 6; 3 M and 3 W) were conducted to gather a general sense of the mental health landscape. Data were analyzed to develop a targeted and comprehensive question guide for gender-specific focus groups (n = 14 unique participants; 6 M and 8 W).ResultsEight themes emerged from the gender-specific focus groups. Themes focusing on work culture described the negative repercussions of job stress and the inability to discuss challenges openly due to confidentiality concerns and feelings of seclusion associated with the CW profession. Men were more likely to be subjected to physical violence and women to emotional and sexual harassment from staff and inmates. Themes related to mental health care described the benefits and limitations of the current services and digital mental healthcare. Stigma and accessibility were notable treatment barriers. Lastly, sector-specific therapy was seen as an important component in enhancing engagement and therapist interaction.ConclusionThe study demonstrates the interconnection between work culture and CW mental health that needs to be acknowledged when addressing mental health care.
Exposure characteristics and risk assessment of air particles in a Chinese hotel kitchen
Authors: Zhou Zanrong , Gao Xiangjing , Cao Yiyao , Zou Hua , Jin Yulan 
Published: October 2022

BackgroundThe hazards of kitchen particles have attracted social attention, but their distribution characteristics and risk assessment are rarely reported.ObjectiveTo explore the temporal and spatial distribution characteristics of kitchen particles, analyze the variations in characteristics of number concentration (NC), mass concentration (MC), surface area concentration (SAC), and particle size distribution, provide reference indexes for evaluating worker exposure, evaluate the risk of kitchen particles, as well as suggest improvements and control measures.Patients and methodsDifferent cooking posts in a Chinese hotel kitchen were selected to monitor exposure to particles, explore the temporal and spatial distribution characteristics of NC, MC, and SAC of particles in the cooking post, analyze changes in the particle size, compare the individual exposure of particles between the cooking and steaming posts, and analyze the correlation between NC, MC, and SAC. Risk assessment of kitchen ultrafine particles was performed using a Nanotool.ResultsThe sizes and fluctuation ranges of NC10 − 500nm at cooking posts during lunch preparation and at peak periods were significantly higher than those at the end of the lunch period. The mean values of MC10 − 500nm during the lunch preparation peak and ending periods were 0.149, 0.229, and 0.151 mg m−3, respectively. The mean values of SAC10 − 500nm were 225, 961, and 466 μm2·cm−3, respectively. The mode diameter of exposed particles at the cooking post [(34.98 ± 2.33) nm] was higher than that at the steaming post [(30.11 ± 2.17) nm] (P &lt; 0.01). The correlation between SAC10 − 500nm and NC10 − 500nm (r = 0.703) was the strongest. Nanotool gave a hazard rating ratio, exposure rating ratio, and risk ratio of 0.75.ConclusionThe sizes of the NC, MC, and SAC of the particles at the cooking post were related to the kitchen operations. Since kitchen particles are of high exposure and risk levels, protective measures should be formulated and implemented to deal with them safely.