bluuebunny/crossref_metadata_2025_split huggingface dataset:
Next generation lanthanide doped nanoscintillators and photon converters
Authors: Lei Lei , Wang Yubin , Kuzmin Andrey , Hua Youjie , Zhao Jingtao , Xu Shiqing , Prasad Paras N. 
Published: September 2022

AbstractScintillators are of significance for the realization of indirect X-ray detection and X-ray excited optical luminescence (XEOL) imaging. However, commercial bulk scintillators not only require complex fabrication procedures, but also exhibit non-tunable XEOL wavelength and poor device processability. Moreover, thick crystals usually generate light scattering followed by evident signal crosstalk in a photodiode array. Lanthanide doped fluoride nanoscintillators (NSs) prepared with low-temperature wet-chemical method possess several advantages, such as low toxicity, cheap fabrication cost, convenient device processability and adjustable emission wavelengths from ultraviolet to visible and extending to second near infrared window. In addition, they exhibit X-ray excited long persistent luminescence (XEPL) making them suitable for broadening the scope of their applications. This review discusses and summarizes the XEOL and XEPL characteristics of lanthanide doped fluoride NSs. We discuss design strategies and nanostructures that allow manipulation of excitation dynamics in a core–shell geometry to simultaneously produce XEOL, XEPL, as well as photon upconversion and downshifting, enabling emission at multiple wavelengths with a varying time scale profile. The review ends with a discussion of the existing challenges for advancing this field, and presents our subjective insight into areas of further multidisciplinary opportunities.
A phase II trial of pembrolizumab and cabozantinib in patients (pts) with recurrent metastatic head and neck squamous cell carcinoma (RMHNSCC).
Authors: Saba Nabil F. , Ekpenyong Asari , McCook-Veal Ashley , Patel Mihir , Schmitt Nicole Cherie , Stokes William A. , Bates James Edward , Rudra Soumon , Abousaud Marin Ibrahim , Muzaffar Jameel , Kirtane Kedar , Teng Yong , Steuer Conor Ernst , Shin Dong Moon , Liu Yuan , Chung Christine H. 
Published: September 2022

6008 Background: Pembrolizumab (pembro) is an immune checkpoint inhibitor (ICI) approved for treating pts with recurrent/metastatic (RM) HNSCC. Cabozantinib (cabo) is a multiple receptor tyrosine kinase inhibitor (TKI) targeting MET and VEGFR2 shown to reduce tumor growth, metastasis, and angiogenesis and has immuno-modulatory properties. Methods: This is a phase II, open label multi-center, single arm trial evaluating the tolerability and clinical benefit of pembro administered at 200 mg every 3 weeks and cabo 40 mg daily for pts with RM HNSCC who have not received prior ICI. It had a lead-in safety cohort allowing reduction of cabo dose to 20mg daily. Eligible pts had RM HNSCC, deemed incurable, with a tumor PD-L1 CPS > 1, RECIST 1.1 measurable disease, a life expectancy of > 3 months, an Eastern Cooperative Group (ECOG) Performance Status (PS) of 0-1. Enrollment was initiated in March of 2019. We estimated that the ORR will improve to 35% with pembro+ cabo (from a historic of 18%) with a significance level of 0.05 and 80% power. Results: A total of 47 pts were screened, 13 screen failures [cavitation on scan (4), inability to swallow pills (2), other exclusions (7)]; 34 pts were enrolled, 32 were dosed and 31 evaluable (at least one follow-up scan). Pts had cancers of the oropharynx (21, 65%), nasopharynx (6, 19%), larynx/hypopharynx (4, 13%) and oral cavity (1,3%). 32 patients received cabo at 40 mg daily; 13 patients (41%) were dose reduced to 20mg daily [mucositis, increased liver function (LFT) tests, diarrhea]; males (n=29, 90%), median age 63 years (range 53-67); presence of distant metastases (34, 100%); prior radiation (29, 90%), chemotherapy (14, 43%); ECOG PS =0 (16, 50%), 1 (16,50%); HPV/p16 positive (17, 53%), negative (5, 16%), not applicable (10, 29%); the most frequent adverse event (AE) (all grades) was fatigue (16,50.0%), grade 3 or 4 treatment-related AE were increased LFTs, hyponatremia (3, 9.3% each). With a median follow up of 12.7 months (mos) (range 6.9- 20.5 mos), a RECIST 1.1 overall response rate ORR= 45.2% (CR=0; PR=14, 45.2%; SD =14, 45.2%; PD=3.0, 10%) with an overall clinical benefit of 90.4% were observed; The 1-yr OS was 67.7% (95% CI, 42.9%-83.6%; median 22.3 mos) and 1-yr PFS was 51.8% (95% CI, 28.8%-70.7%; median 14.6 mos). Conclusions: This phase II trial of pembro + cabo met its primary endpoint of ORR. The regimen is well-tolerated with very encouraging clinical activity in RM HNSCC and warrants further exploration in this disease. The study was supported by a grant from Exelixis to NFS. Clinical trial information: NCT03468218.
Audio geolocalizado. El móvil como mediador de experiencias del patrimonio inmaterial
Authors: Piñeiro-Otero Teresa , Martínez-Rolán Xabier , Mihura López Rocío 
Published: September 2022

Las nuevas tecnologías no solo han transformado las estrategias de difusión patrimonial, también han favorecido una reflexión en torno a cuestiones como patrimonio, cultura, identidad y participación. La vinculación del patrimonio cultural con el espacio y las comunidades que lo habitan, y la multiplicación de los terminales móviles conectados en los bolsillos de las personas, con sus potencialidades implícitas para la geolocalización y participación han propiciado el desarrollo de nuevas experiencias basadas en la interacción y retroalimentación del espacio virtual y del espacio real. En este sentido, el presente trabajo efectúa una revisión bibliográfica de la literatura de la investigación sobre el sonido como elemento cultural e identitario de un lugar-comunidad, poniendo especial énfasis en las narrativas sonoras como forma de expresión-visibilización del patrimonio cultural para proveer experiencias únicas e inmersivas del espacio, diferentes de las tradicionales. Unas expresiones que aúnan creatividad, diversidad social-cultural y las potencialidades de geoposicionamiento de los dispositivos para ofrecer unas rutas alternativas de la ciudad
Comparison of patient-reported outcomes at one year after injury between limb salvage and amputation: A prospective cohort study
Authors: Kurozumi Taketo , Inui Takahiro , Nakayama Yuhei , Honda Akifumi , Matsui Kentaro , Ishii Keisuke , Suzuki Takashi , Watanabe Yoshinobu 
Published: September 2022

Purpose
This single-center, prospective cohort study aimed to compare the patient-reported outcomes one year after injury between limb salvage and amputation and to elucidate whether amputation contributes to early recovery of functionality and quality of life.

Methods
We included 47 limbs of 45 patients with severe open fractures of the lower limb and categorized them into limb salvage and amputation groups. Data on patient-reported outcomes one year after injury were obtained from the Database of Orthopaedic Trauma by the Japanese Society for Fracture Repair at our center. Patients’ limbs were evaluated using the lower extremity functional scale and Short-Form 8. Early recovery was assessed using functionality and quality-of-life questionnaires.

Results
Of the 47 limbs, 34 limbs of 34 patients were salvaged, and 13 limbs of 11 patients were amputated. Significant differences were noted between the limb salvage and amputation groups in terms of the lower extremity functional scale scores (mean: 49.5 vs. 33.1, P = 0.025) and scores for the mental health component (mean: 48.7 vs. 38.7, P = 0.003), role–physical component (mean: 42.2 vs. 33.3, P = 0.026), and mental component summary (mean: 48.2 vs. 41.3, P = 0.042) of the Short-Form 8. The limb salvage group had better scores than the amputation group.

Conclusions
As reconstruction technology has advanced and limb salvaging has become possible, the focus of studies should now be based on the perspective of “how the patient feels;” hence, we believe that the results of this study, which is based on patient-reported outcomes, are meaningful.
Comparative efficacy and safety of caffeine citrate and aminophylline in treating apnea of prematurity: A systematic review and meta-analysis
Authors: Miao Yiqun , Zhou Yun , Zhao Shuliang , Liu Wenwen , Wang Aihua , Zhang Yuanyuan , Li Yanan , Jiang Huimin 
Published: September 2022

Background
Methylxanthine, including caffeine citrate and aminophylline, is the most common pharmacologic treatment for apnea of prematurity. However, due to the lack of high-quality evidence, there are no clear recommendations or guidelines on how to choose between caffeine and aminophylline.

Objective
This meta-analysis aimed to assess the comparative efficacy and safety of caffeine and aminophylline for apnea of prematurity, and provide reliable evidence for clinical medication in the treatment for apnea of prematurity.

Methods
PubMed, Scopus, Embase, EBSCO, Web of Science, and Cochrane databases were systematically searched from May 1975 to June 2022.

Results
Ten studies including a total of 923 preterm infants were evaluated. Our results showed that there was no significant difference in the effective rate of 1-3days between caffeine and aminophylline (OR 1.05, 95%CI: 0.40–2.74, P = 0.914). However, for side effects such as tachycardia (OR 0.22, 95%CI: 0.13–0.37, P<0.001) and feeding intolerance (OR 0.40, 95%CI: 0.23–0.70, P = 0.001), the incidence rate was lower in the caffeine group compared with the aminophylline group. No significant difference was found in hyperglycemia (OR 0.45, 95%CI: 0.19–1.05, P = 0.064).

Conclusion
This meta-analysis reveals that caffeine citrate and aminophylline have similar therapeutic effectiveness on respiratory function, but caffeine has fewer side effects and should be considered first for treatment.
Neurotrauma clinicians’ perspectives on the contextual challenges associated with traumatic brain injury follow up in low-income and middle-income countries: A reflexive thematic analysis
Authors: Smith Brandon G. , Whiffin Charlotte J. , Esene Ignatius N. , Karekezi Claire , Bashford Tom , Mukhtar Khan Muhammad , Fontoura Solla Davi J. , Indira Devi Bhagavatula , Paiva Wellingson S. , Servadei Franco , Hutchinson Peter J. , Kolias Angelos G. , Figaji Anthony , Rubiano Andres M. 
Published: September 2022

BackgroundTraumatic brain injury (TBI) is a major global health issue, but low- and middle-income countries (LMICs) face the greatest burden. Significant differences in neurotrauma outcomes are recognised between LMICs and high-income countries. However, outcome data is not consistently nor reliably recorded in either setting, thus the true burden of TBI cannot be accurately quantified.ObjectiveTo explore the specific contextual challenges of, and possible solutions to improve, long-term follow-up following TBI in low-resource settings.MethodsA cross-sectional, pragmatic qualitative study, that considered knowledge subjective and reality multiple (i.e. situated within the naturalistic paradigm). Data collection utilised semi-structured interviews, by videoconference and asynchronous e-mail. Data were analysed using Braun and Clarke’s six-stage Reflexive Thematic Analysis.Results18 neurosurgeons from 13 countries participated in this study, and data analysis gave rise to five themes: Clinical Context: What must we understand?; Perspectives and Definitions: What are we talking about?; Ownership and Beneficiaries: Why do we do it?; Lost to Follow-up: Who misses out and why?; Processes and Procedures: What do we do, or what might we do?ConclusionThe collection of long-term outcome data plays an imperative role in reducing the global burden of neurotrauma. Therefore, this was an exploratory study that examined the contextual challenges associated with long-term follow-up in LMICs. Where technology can contribute to improved neurotrauma surveillance and remote assessment, these must be implemented in a manner that improves patient outcomes, reduces clinical burden on physicians, and does not surpass the comprehension, capabilities, or financial means of the end user. Future research is recommended to investigate patient and family perspectives, the impact on clinical care teams, and the full economic implications of new technologies for follow-up.
Multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS
Authors: Batra Richa , Whalen William , Alvarez-Mulett Sergio , Gomez-Escobar Luis G. , Hoffman Katherine L. , Simmons Will , Harrington John , Chetnik Kelsey , Buyukozkan Mustafa , Benedetti Elisa , Choi Mary E. , Suhre Karsten , Schenck Edward , Choi Augustine M. K. , Schmidt Frank , Cho Soo Jung , Krumsiek Jan 
Published: September 2022

BackgroundAcute respiratory distress syndrome (ARDS), a life-threatening condition characterized by hypoxemia and poor lung compliance, is associated with high mortality. ARDS induced by COVID-19 has similar clinical presentations and pathological manifestations as non-COVID-19 ARDS. However, COVID-19 ARDS is associated with a more protracted inflammatory respiratory failure compared to traditional ARDS. Therefore, a comprehensive molecular comparison of ARDS of different etiologies groups may pave the way for more specific clinical interventions.Methods and findingsIn this study, we compared COVID-19 ARDS (n = 43) and bacterial sepsis-induced (non-COVID-19) ARDS (n = 24) using multi-omic plasma profiles covering 663 metabolites, 1,051 lipids, and 266 proteins. To address both between- and within- ARDS group variabilities we followed two approaches. First, we identified 706 molecules differently abundant between the two ARDS etiologies, revealing more than 40 biological processes differently regulated between the two groups. From these processes, we assembled a cascade of therapeutically relevant pathways downstream of sphingosine metabolism. The analysis suggests a possible overactivation of arginine metabolism involved in long-term sequelae of ARDS and highlights the potential of JAK inhibitors to improve outcomes in bacterial sepsis-induced ARDS. The second part of our study involved the comparison of the two ARDS groups with respect to clinical manifestations. Using a data-driven multi-omic network, we identified signatures of acute kidney injury (AKI) and thrombocytosis within each ARDS group. The AKI-associated network implicated mitochondrial dysregulation which might lead to post-ARDS renal-sequalae. The thrombocytosis-associated network hinted at a synergy between prothrombotic processes, namely IL-17, MAPK, TNF signaling pathways, and cell adhesion molecules. Thus, we speculate that combination therapy targeting two or more of these processes may ameliorate thrombocytosis-mediated hypercoagulation.ConclusionWe present a first comprehensive molecular characterization of differences between two ARDS etiologies–COVID-19 and bacterial sepsis. Further investigation into the identified pathways will lead to a better understanding of the pathophysiological processes, potentially enabling novel therapeutic interventions.
Accounting Policies and Dividend Limitation: A European Comparison
Authors: Le Manh Anne 
Published: September 2022

Abstract
The adoption of IFRS by the EU has raised issues about its economic consequences in terms of, among others, volatility of corporate profits, taxation of profit and distribution of dividends. Indeed, it has brought the interactions between legal rules for dividend distribution and accounting policies back into focus. The EU company and accounting regulations are based on capital maintenance rules that involve limitations on dividend distribution when certain accounting policies are implemented in individual financial statements under local GAAP. However, while a majority of member states permit IFRS for individual financial statements, the EU regulations are silent on this issue. In this article, we outline an in-depth analysis on legal dividend distribution rules interactions with accounting policies in European countries, whether local GAAP or IFRS are applied. We have selected nine cases of potential recognition of unrealised gains in individual financial statements under local GAAP and/or IFRS, some of which are already specified in the EU regulations. For each case, we have analysed the national accounting regulations and the corporate laws. Our analysis reveals that the limitations on dividend distributions recommended by the EU have been most largely implemented in the national regulations, but not in all countries. It also sheds light on potential loopholes in the current European regulation regarding unrealised gains that may be more systematically recognised under IFRS than under local GAAP: unrealised gains arising from the recognition of deferred tax assets and unrealised gains arising from benefit pensions plan. To fill these gaps in the national regulations and to harmonise the legal basis for dividend distribution better within the EU, we suggest including in the European regulation the concept of ‘realised profits’ and thus ‘distributable profits’ as a required basis for dividend distribution. It involves in the first place identifying relevant criteria that may enable disentangling realised and unrealised profits or losses.
Accounting Research’s “Flat Earth” Problem
Authors: Cready William M. 
Published: September 2022

Abstract
This essay advances the possibly startling notion that as a matter of largely conceptual understanding, the vast majority of accounting research’s empirical efforts concern tests of null hypotheses that are, a priori, false. Figuratively speaking, our journals specialize in providing compelling evidence that ‘the earth is not flat’. It further presents thoughts on the causes and consequences of this state of affairs. Moreover, while other fields also suffer from this ‘flat earth’ condition, it argues that as a field that specializes in issues surrounding the conveyance of useful information, the accounting academy should step up and take leadership on dealing with the problem. The essay closes by discussing how the field might venture forth from this sheltered approach to empirical inference and thereby enhance the discovery content of its empirical inquiries.
Growth Competitions on Spherically Symmetric Riemannian Manifolds
Authors: Assouline Rotem 
Published: September 2022

Abstract
We propose a model for a growth competition between two subsets of a Riemannian manifold. The sets grow at two different rates, avoiding each other. It is shown that if the competition takes place on a surface which is rotationally symmetric about the starting point of the slower set, then if the surface is conformally equivalent to the Euclidean plane, the slower set remains in a bounded region, while if the surface is nonpositively curved and conformally equivalent to the hyperbolic plane, both sets may keep growing indefinitely.
A focusing study on radioprotective and antioxidant effects of Annona muricata leaf extract in the circulation and liver tissue: Clinical and experimental studies
Authors: Elmas Ozlem , Sahin Havva Hande Keser , Guven Berrak , Abuzaid Mohamed M. , Elshami Wiam , ALMisned Ghada , Zakaly Hesham M. H. , Ene Antoaneta , Tekin Huseyin Ozan 
Published: September 2022

Abstract

Objectives
This study investigates the effect of Annona muricata (AM) leaf extract against irradiation-induced damage by the evaluation of hepatic tissue and the levels of oxidative and inflammatory stress in the circulation.

Methods
An experimental study with 37 female Wistar albino rats randomized into four groups (controls and three intervention groups) was performed. The first interventional group (group 2) received 300 mg/kg of AM leaf extract by oral gavage once a day for 9 days, group 3 received a single dose of whole-body radiation (8.3 Gy) after a 9-day oral gavage treatment with saline, and the last group received the same irradiation of 8.3 Gy after being treated with 300 mg/kg of AM leaf extract by oral gavage once a day for 9 days.

Results
Radiation was found to elevate reactive oxygen species parameters, and AM administration before irradiation was found to decrease total oxidant status (TOS), increase caspase 9, and improve hepatic damage when compared with the group that received only irradiation.

Conclusion
The damage caused by irradiation may be ameliorated by the use of the AM extract, which appears to be effective in preventing oxidative stress and inflammatory activity.
Cultural capital as a background of media use and civic engagement
Authors: Jedrzejewski Stanislaw 
Published: September 2022

Abstract
This article outlines the relationship that cultural capital, which is identified as a media user’s education level, shares with news media consumption patterns, civic engagement, and cultural participation. The article’s findings are based on data gathered during a 2015 investigation on news media consumption conducted by a group of European researchers as part of a comparative research project, supplemented with data from a survey on a random sample of Polish citizens conducted in May 2019. The project for the empirical 2015 study aimed to examine the principles of building individual media repertoires as a representation of media usage patterns and experiences related to news media consumption.
The study focused on universal aspects of news media consumption, while simultaneously allowing for the discovery of aspects of news media use that are specific to the individual countries participating in the study: Germany, Denmark, Israel, Belgium-Fr., Belgium-Flanders, Portugal, Spain, the Netherlands, Croatia, and Poland.
Measuring academic satisfaction in nursing students: a systematic review of the instruments
Authors: Rossini Silvia , Mazzotta Rocco , Kangasniemi Mari , Badolamenti Sondra , Macale Loreana , Sili Alessandro , Vellone Ercole , Alvaro Rosaria , Bulfone Giampiera 
Published: September 2022

Abstract
Student academic satisfaction is one of the most important factors affecting the success and quality of a higher education institute and is an indicator about teaching and learning. This study aims to summarize and critically evaluate the instruments assessing academic satisfaction in nursing education. A systematic review was undertaken, PRISMA were used for the screening of studies. MEDLINE, Cochrane, Scopus and CINAHL were searched using MeSH terms; seven eligible articles were identified referring to five assessment tools. COSMIN was used for evaluation of the methodological of the instruments. The systematic review identified five satisfaction measurement tools used in nursing education. The analysis of the instruments rarely considered a confirmative validity structure, measurement error or criterion validity. The best available instrument was the Nursing Students Satisfaction Scale (NSSS) for validation methodology; however, it needs further validation studies that consider CFA, reliability, criteria validity, hypothesis testing and measurement error.