bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smaller left ventricular end-systolic diameter and lower ejection fraction at baseline associated with greater ejection fraction improvement after revascularization among patients with left ventricular dysfunction
Authors: Wang Shaoping , Lyu Yi , Cheng Shujuan , Zhang Yuchao , Gu Xiaoyan , Gong Ming , Liu Jinghua 
Published: September 2022

ObjectivesTo investigate the predictive roles of pre-operative left ventricular (LV) size and ejection fraction (EF) in EF improvement and outcome following revascularization in patients with coronary artery disease (CAD) and LV dysfunction.BackgroundRevascularization may improve EF and long-term outcomes of patients with LV dysfunction. However, the determinants of EF improvement have not yet been investigated comprehensively.Materials and methodsPatients with EF measurements before and 3 months after revascularization were enrolled in a cohort study (No. ChiCTR2100044378). All patients had baseline EF ≤ 40%. EF improvement was defined as absolute increase in EF &gt; 5%. According to LV end-systolic diameter (LVESD) (severely enlarged or not) and EF (≤35% or of 36–40%) at baseline, patients were categorized into four groups.ResultsA total of 939 patients were identified. A total of 549 (58.5%) had EF improved. Both LVESD [odds ratio (OR) per 1 mm decrease, 1.05; 95% CI, 1.04–1.07; P &lt; 0.001] and EF (OR per 1% decrease, 1.06; 95% CI, 1.03–1.10; P &lt; 0.001) at baseline were predictive of EF improvement after revascularization. Patients with LVESD not severely enlarged and EF ≤ 35% had higher odds of being in the EF improved group in comparison with other three groups both in unadjusted and adjusted analysis (all P &lt; 0.001). The median follow-up time was 3.5 years. Patients with LVESD not severely enlarged and EF ≤ 35% had significantly lower risk of all-cause death in comparison with patients with LVESD severely enlarged and EF ≤ 35% [hazard ratio (HR), 2.73; 95% CI, 1.28–5.82; P = 0.009], and tended to have lower risk in comparison with patients with LVESD severely enlarged and EF of 36–40% (HR, 2.00; 95% CI, 0.93–4.27; P = 0.074).ConclusionAmong CAD patients with reduced EF (≤ 40%) who underwent revascularization, smaller pre-operative LVESD and lower EF had greatest potential to have EF improvement and better outcome. Our findings imply the indication for revascularization in patients with LV dysfunction who presented with lower EF but smaller LV size.
Prognostic impact of physical activity patterns after percutaneous coronary intervention. Protocol for a prospective longitudinal cohort. The PIPAP study
Authors: Gonzalez-Jaramillo Nathalia , Eser Prisca , Casanova Flurina , Bano Arjola , Franco Oscar H. , Windecker Stephan , Räber Lorenz , Wilhelm Matthias 
Published: September 2022

IntroductionCurrent guidelines recommend wearable activity trackers to detect insufficient physical activity (PA) and help increase PA to prevent or ameliorate cardiovascular disease. However, there is a paucity of data regarding how objectively measured PA trajectories, patterns, and sedentary time, are associated with mortality and recurrent events after percutaneous coronary intervention (PCI) in patients with established coronary artery disease (CAD). Additionally, it remains unclear if early PA and sedentary time after PCI are associated with such outcomes. Therefore, in the present study (ClinicalTrials.gov Identifier: NCT04663373), we aim to establish the associations of objectively measured PA with major adverse cardiac events and mortality at one-year follow-up.Methods and analysisIn this single-centre observational study, patients with CAD will be prospectively recruited immediately after PCI. All the information from the clinical history, baseline characteristics, and outcomes during follow-up will be obtained from the CARDIOBASE registry. Accelerometer data will be collected for 18 days following hospital discharge and 14 days at one-year follow-up. PA trajectories will be identified by group-based trajectory modeling. Major adverse cardiac events and mortality will be prospectively monitored up to 1 year after PCI. All data will be collected using Research Electronic Data Capture.
Adherence and persistence to oral anticoagulants in patients with atrial fibrillation: A Belgian nationwide cohort study
Authors: Grymonprez Maxim , Capiau Andreas , Steurbaut Stephane , Mehuys Els , Boussery Koen , De Backer Tine L. , Lahousse Lies 
Published: September 2022

BackgroundSince non-vitamin K antagonist oral anticoagulants (NOACs) do not require coagulation monitoring, concerns of lower adherence and persistence to NOACs than vitamin K antagonists (VKAs) have been raised. Moreover, little is known on the frequency of permanent cessation and switching between anticoagulants in patients with atrial fibrillation (AF). Therefore, persistence, reinitiation, switching and adherence to oral anticoagulants (OACs) were investigated.Materials and methodsAF patients with a first OAC prescription claim between 2013 and 2019 were identified in Belgian nationwide data. Persistence, reinitiation and switching were estimated using Kaplan-Meier analyses. Adherence was investigated using the proportion of days covered (PDC). Predictors for non-adherence and non-persistence were identified by multivariable logistic regression.ResultsAmong 277,782 AF patients, 69.6% NOAC and 37.2% VKA users were persistent after 1 year, whereas 44.3% and 18.9% after 5 years, respectively. After one year, 67.1% rivaroxaban, 68.1% dabigatran, 69.8% apixaban, and 76.9% edoxaban users were persistent. Among subjects having discontinued NOAC or VKA treatment, 75.4% and 46.1% reinitiated any OAC within 5 years, respectively. VKAs were more frequently switched to NOACs than vice versa (17.6% versus 2.5% after 1 year). After 1 year, a high PDC (≥ 90%) was observed in 87.8% apixaban, 88.6% dabigatran, 91.3% rivaroxaban, and 94.7% edoxaban users (90.2% NOAC users). Adherence and persistence were higher in older, female subjects, while lower in subjects with dementia or hyperpolypharmacy.ConclusionAdherence and persistence to NOACs were high. However, 10% of subjects were non-adherent after 1 year and one-fourth did not reinitiate anticoagulation within 5 years after NOAC discontinuation.
Analysis of 2D and 3D GPR data interpretation using continuous wavelet transforms: Case study from an archaeological test site
Authors: Iqbal Ibrar , Xiong Bin , Tian Gang , Ali Amjad , Peng Sanxi , Wen Gao , Huang Xingfu , Anees Aqsa , Ashraf Umar , Abd El-Raouf Amr 
Published: September 2022

Ground-penetrating radar (GPR) is one of the most important techniques for obtaining high-resolution data in archaeological research, and it is becoming increasingly important. The continuous wavelet transform (CWT), which is non-numerical technique, gives an overcomplete representation of a signal by continuously varying the wavelet’s translation and scale parameters in the time series dataset. This paper focuses on the novel technique of integrating CWT and the wavelet transform maxima (WTM) to extract information from an archaeological test site in south-eastern China. For the characterization of archaeological features, we assessed the importance of dense and accurate data collection as well as GPR signal processing. The mathematical formulation and applicability of GPR attributes, particularly amplitude-based attributes, to identify and characterize archaeological buried targets are also discussed. GPR data is acquired using co-polarized and cross-polarized configurations with transverse-electric (TE) and transverse-magnetic (TM) broadside frequency plates at 100 and 200 MHz. Next, CWT was applied using six different wavelet levels, followed by amplitude comparison. The archaeological targets were successfully interpreted using peak amplitude and CWT. The proposed methodology has significantly improved data visualization and interpretation of GPR data, and it also gave us good results in identifying archaeological anomalies.
Active degassing of crustal CO2 in areas of tectonic collision: A case study from the Pollino and Calabria sectors (Southern Italy)
Authors: Randazzo Paolo , Caracausi Antonio , Aiuppa Alessandro , Cardellini Carlo , Chiodini Giovanni , Apollaro Carmine , Paternoster Michele , Rosiello Angelo , Vespasiano Giovanni 
Published: September 2022

Carbon dioxide (CO2) is released from the Earth’s interior into the atmosphere through both volcanic and non-volcanic sources in a variety of tectonic settings. A quantitative understanding of CO2 outgassing fluxes in different geological settings is thus critical for decoding the link between the global carbon budget and different natural processes (e.g., volcanic eruption and earthquake nucleation) and the effects on the climate evolution over geological time. It has recently been proposed that CO2 degassing from non-volcanic areas is a major component of the natural CO2 emission budget, but available data are still sparse and incomplete. Here, we report the results of a geochemical survey aimed at quantifying CO2 emissions through cold and thermal springs of the tectonically active Pollino Massif and Calabrian arc (Southern Italy). The chemical ad isotopic (He and C) composition of fifty-five dissolved gas samples allows to identify two different domains: 1) a shallow system dominated by gas components of atmospheric signature (helium, hereafter He) and biogenic origin (C), and 2) a deeper system in which crustal/deep fluids (CO2 and He) are dominant. The measured He isotope ratios range from 0.03 to 1.1 Ra (where Ra is the He isotopic ratio in the atmosphere) revealing a variable atmospheric contamination. Furthermore, the He isotopic data indicate the presence of traces of mantle He contributions (2%–3%) in the thermal groundwater. The prevailing low R/Ra values reflect the addition of crustal radiogenic 4He during groundwater circulation. Using helium and carbon isotope data, we explore the possible sources of fluids and the secondary processes (dissolution/precipitation) that act to modify the chemistry of pristine volatiles. For the thermal springs, we estimate a deep C output of 2.3 x 107 to 6.1 x 108 mol year−1. These values correspond to deep CO2 fluxes per square km comparable with those estimated in several active and inactive volcanic areas and in continental regions affected by metamorphic CO2 degassing (e.g., the southern margin of the Tibetan Plateau).
Latitudinal changes in submarine channel-levee system evolution, architecture and flow processes
Authors: Allen Charlotte , Peakall Jeff , Hodgson David M. , Bradbury Will , Booth Adam D. 
Published: September 2022

Models of the sedimentary architecture of submarine channel-levee systems and their formative flow processes are predominantly based on studies from low latitude settings. Here, we integrate high-resolution seismic reflection, bathymetry and GLORIA side scan data to document the architecture and interpret the formative processes of a series of ultra-high latitude (72–76°N) submarine channel-levee systems that feed lobe complexes off the Greenland margin. We demonstrate that the sedimentary architecture of the channel-fills are dominated by vertical or near-vertical sediment accumulation, reflecting the lack of, or very limited nature of, lateral migration over time. All the Greenland channel-levee systems show significant cross-sectional asymmetry, and a peak sinuosity of 1.38, on a low gradient slope (∼0.3°). The bounding external levees are very thick (∼200 m) and wide relative to low latitude systems. Comparison of these channel-levee systems with other examples reveals that these characteristics appear to be common to systems in high and ultra-high latitudes, suggesting latitudinal controls in the sedimentary architecture of submarine channel-levee systems. The differences between high- and low-latitude systems is likely due to the interplay of physical forcing (i.e., Coriolis force) and climatic factors that control sediment calibre and flow type, both of which are latitudinally dependent. Several formative mechanisms for supressing the initial phase of lateral migration and subsequent asymmetrical development are proposed, including:i) rapid channel aggradation, (ii) Coriolis forcing causing preferred deposition on the right-hand side of the channel, and iii) variance in flow properties, with traction- and suspension-dominated flows deposited on opposing sides of the channel. We argue that a high latitudinal location of larger channel-levee systems may result in the dominance of vertical stacking of channels, the construction of large external levees, and the development of a low sinuosity planform.
The Evangelical Puzzle Partially Explained: Privileged Prejudice and the Development of Appreciative Attitudes Toward Evangelical Christianity
Authors: Mayhew Matthew J. , Winkler Christa E. , Staples B. Ashley , Singer Kevin , Shaheen Musbah , Rockenbach Alyssa N. 
Published: September 2022

Background:Evangelical Christian college students simultaneously experience the privileges that accompany dominant religious identities and feel a need to conceal their identity and perspectives on college campuses. Consistently and empirically, the college campus has been studied for its potential to help students develop appreciative attitudes toward religious, secular, and spiritual worldviews. Yet, few studies have investigated evangelical Christian appreciation longitudinally over 4 years of college, and even fewer through the additional use of a mixed-methods design.Purpose:This inquiry examined if and how college students developed an appreciation of evangelical Christianity over 4 years of college.Methods:This paper used data gathered through the Interfaith Diversity Experiences and Attitudes Longitudinal Survey (IDEALS), a nationally-representative, mixed-methods study that included survey data collection from 9,470 students at 122 colleges and universities over 3 time points, and 18 qualitative case studies conducted across institutions of various sizes, locations, and affiliations.Results:Using latent growth modeling, we demonstrated that overall appreciation for evangelical Christianity developed during college and was related to institutional cultures that invited and embraced worldview diversity as well as religiously-inclusive campus climates and practices. Related qualitative insights storied change in evangelical appreciation that centered on personal relationships with evangelicals, efforts to understand evangelical viewpoints, and a recognition that Christian students often have the privilege of operating from unexamined beliefs.Conclusion and Implications:Study results provide recommendations for educational practices that support student growth from tolerance to appreciation for evangelical Christianity.
Causal associations of obesity related anthropometric indicators and body compositions with knee and hip arthritis: A large-scale genetic correlation study
Authors: Wang Chao , Zhu Yong , Liu Zhi , Long Haitao , Ruan Zhe , Zhao Shushan 
Published: September 2022

BackgroundsEpidemiological studies have repeatedly investigated the association between obesity related anthropometric indicators and body compositions and osteoarthritis (OA). However, the results have remained inconsistent. This work aimed to investigate the genetic correlation and causal associations of obesity related anthropometric indicators and body compositions with knee and hip OA.MethodsSingle-nucleotide polymorphisms associated with the exposures were searched from the recent genome-wide association studies (GWAS) to obtain full statistics. Summary-level results of knee and hip OA were from the UK Biobank and arcOGEN. First, linkage disequilibrium score regression (LD score regression) was applied to detect the genetic correlation (rg). We further performed a series of sensitivity analyses as validation of primary mendelian randomization (MR) results and the specific evidence of potential causal effects was defined.ResultsWe found that genetic components in OA had significant correlation with obesity related traits, except waist-to-hip ratio. In the univariable MR analysis, with the exception of waist-to-hip ratio, obesity related anthropometric indicators were causally associated with increased risks of knee and hip OA. For obesity related body compositions, higher fat-free mass in arm, leg, and whole body increased the risk of knee OA but only fat-free mass in leg showed a significant association with hip OA. Meanwhile trunk fat mass and trunk fat percentage, were associated with knee but not with hip OA. Higher fat mass, and fat percentage in arm, leg, and whole body increased the risk of both knee and hip OA. After adjusting for BMI, the multivariable MR showed maintained results in knee OA. However, in hip OA, only fat mass and fat-free mass in arm, leg, trunk and whole body were significantly associated with the risk of hip OA.ConclusionThe present study suggests genetic evidence for certain causal associations of obesity related anthropometric indicators and body compositions with knee and hip OA, which may provide important insights for the prevention and treatment on OA.
Dry season forage assessment across senegalese rangelands using earth observation data
Authors: Lo Adama , Diouf Abdoul Aziz , Diedhiou Ibrahima , Bassène Cyrille Djitamagne Edouard , Leroux Louise , Tagesson Torbern , Fensholt Rasmus , Hiernaux Pierre , Mottet Anne , Taugourdeau Simon , Ngom Daouda , Touré Ibra , Ndao Babacar , Sarr Mamadou Adama 
Published: September 2022

Strengthening of feed security in the Sahel is urgently needed given the climate change and growing human population. A prerequisite to this is sustainable use of rangeland forage resources for livestock. Many studies have focused on the assessment of rangeland resources during the rainy season, while only a few have focused on the dry season which is the longest and most demanding period for livestock in Sahelian rangelands. The objective of this study is to develop remote sensing-based models for estimating dry season forage vegetation mass. To that end, 29 vegetation indices calculated from each of the MODIS-MCD43A4 (500 m), Landsat-8 (30 m), and Sentinel-2 (10 m) satellite products were used and tested against in situ data collected during three field-measurement campaigns in 2021 at eleven monitoring sites across Senegalese rangelands. Four statistical models were tested, namely, random forest, gradient boosting machines, and simple linear and multiple linear regressions. The two main vegetation mass variables modeled from remote sensing imagery were the standing herbaceous and litter dry mass (BH) and total forage dry mass (BT) with a dry mass of woody plant leaves added to BH. Overall, Sentinel-2 data provided the best performance for the assessment of BH with multiple linear regression (R2 = 0.74; RMSE = 378 kg DM/ha) using NDI5 (Normalized Difference Index5), GRCI (Green Residue Cover Index), SRI (Simple Ratio Index), TCARI (Transformed Chlorophyll Absorption in Reflectance Index), and DFI (Dead Fuel Index) indices. For BT, the best model was also obtained from Sentinel-2 data, including RVI3 (Ratio Vegetation Index3) (R2 = 0.78; RMSE = 496 kg DM/ha). Results showed the suitability of combining the red, green, blue, NIR, SWIR1, and SWIR2 bands in monitoring forage availability during the dry season. Our study revealed that the spectral richness of the optical sensor systems Sentinel-2, Landsat-8, and MODIS-MCD43A4 allowed for accurate assessments of dry-season forage mass of semi-arid rangelands. Adding to this, the high spatial and temporal resolution of Sentinel-2 satellite imagery makes this a promising data source for timely monitoring. These findings can support the monitoring of the animal feed balance in Sahelian countries and contribute to enhancing the resilience of pastoralism toward feed shortage through early warning systems.
Rural transformation and differential vulnerability: Exploring adaptation strategies to water scarcity in the Aculeo Lake basin (Chile)
Authors: Ocampo-Melgar Anahi , Barria Pilar , Chadwick Cristian , Diaz-Vasconcellos Raúl 
Published: September 2022

The way of life of agricultural rural territories and their long-term capacity to adapt to changes will be challenged not only by the impacts of climate change; but by increased vulnerability stemming from previous inadequate climate adaptations and development policies. Studies that deepen understanding of the differential causes and implications of vulnerabilities will improve adaptation or transformation of institutions for climate change. The Aculeo basin of Central Chile suffered an extreme 10-years rainfall deficit that resulted in the disappearance of a 12 km2lake and the economic transformation of the territory. This paper presents a cross-scale exploration of the political, cultural and historical interconnections behind this dramatic story, while critically discussing whether today’s land use configuration reflects the territory’s adaptive capacity. The story is reconstructed using land-use change analysis along with literature review and Causal-Loop Analysis. Results show how previous policies and other human factors contributed to the agroecosystem transformation, creating different vulnerabilities in different economic sectors. Today, what is observed as disparate capacities to adapt to climatic drought is actually the result of historic exacerbations of the vulnerabilities that had significantly contributed to the water scarcity crisis.
Investigation of critical response characteristics of micro-droplets under the action of low-frequency acoustic waves
Authors: Bai Wenwen , Shi Yang , Zhao Zhifeng , Wei Jiahua 
Published: September 2022

For the droplets with different size distribution, reasonably selecting the frequency and period of acoustic waves are of great significance to acoustic agglomeration. To investigate critical responses of microdroplets under the action of low-frequency acoustic waves, laboratory experiments and numerical simulations of acoustic interference were conducted, and statistical test and theoretical analysis were carried out. A total of 1,680 sets of experiments were performed, from which about 300,000 particle size samples were collected, with sound frequency of 30–280 Hz and the sound pressure level (SPL) of 70–130 dB. Droplet size distribution (DSD), equilibrium response time (ERT), the nodal plane in the air chamber and entrainment coefficient were analyzed. The critical SPL of acoustic agglomeration was 110 ± 15 dB based on average droplet size increment, and the variation of droplet size indicated that the ERT of acoustic intervention on microdroplets under the critical SPL was 44 ± 12 s. In addition, lower sound frequencies corresponded to larger widths of droplet size with significant response (DSSR), which were jointly affected by sound pressure gradient (SPG), the entrainment coefficient and the droplet concentration. For microdroplets with unknown particle size distribution, acoustic intervention with variable frequencies is suggested for fog elimination and precipitation enhancement.