bluuebunny/crossref_metadata_2025_split huggingface dataset:
The management of an oral pyogenic granuloma around osseointegrated dental implants
Authors: Burgess Danielle K. , Levi Paul A. , Kim David M. 
Published: July 2022

AbstractIntroductionOral pyogenic granulomas (PGs) presenting in association with dental implants are uncommon occurrences. While tooth‐associated PGs are well‐documented in the literature, there are only seven case reports with biopsy‐confirmed diagnoses of PG related to dental implants. This case report details the treatment of an intraoral PG related to dental implants that had been osseointegrated and asymptomatic for 10 years.Case PresentationA 39‐year‐old female presented with a hyperplastic erythematous mass that encompassed the dental implants in the position of the maxillary central incisors. Surgical exploration of the site revealed nonintegrated, particulate bone material distributed throughout the peri‐implant tissues approximating the granuloma. Treatment involved surgical excision of the lesion, elimination of all nonintegrated bone material, and implant surface debridement. Laser therapy was later used to manage a recurrence. Histology of the biopsied tissue confirmed the diagnosis of PG and described the presence of multiple exogenous, refractile, particulate materials in the specimen.ConclusionThe combination of surgical excision, implant debridement, and conservative laser therapy resulted in the elimination of a dental implant‐related PG and successful soft tissue management. The localized presence of nonintegrated particulate bone material surrounding the granuloma appears to have functioned as a chronic irritant to the peri‐implant soft tissues over time and is likely, along with oral bacteria, the primary etiological agents.Key pointsWhy is this case new information?

There is a paucity of reports describing the management of dental implant‐related pyogenic granulomas especially in the esthetic region. The present case demonstrates that particulate bone materials used in guided bone regeneration have the capacity to behave as a low‐grade irritant to the gingival tissues. It also demonstrates the successful elimination of the tissues and management of the peri‐implant soft tissues for an esthetic result.
What are the keys to successful management of this case?

The key to successful management of this case was adequate removal of the exogenous irritant, proper implant surface debridement, and decontamination and adequate gingivoplasty to remove all residual hyperplastic granulomatous tissues. Additionally, patient education and appropriate oral hygiene instructions were important to proper healing and maintenance of the area.
What are the primary limitations to success in this case?

The ambiguity of the clinical boundaries of PGs makes it challenging to guarantee complete excision beyond the base of the lesion, leading to recurrence.
Virtual enhanced education in counselor education: Is this for real?
Authors: Sacco‐Bene Christine , Walsh Michael J. , Dawson Robert D. , Petrino Janet , Boening Emily 
Published: August 2022

AbstractMost applications of virtual reality and technology used in counseling occur in the context of client intervention and treatment. This article presents how virtual enhanced education tools such as virtual reality, augmented reality, and 360° videos provide a stage for constructing creative opportunities for experiential learning in counselor education.
Bimetallic Ruthenium Nitrosyl Complexes with Enhanced Two‐Photon Absorption Properties for Nitric Oxide Delivery
Authors: Juarez‐Martinez Yael , Labra‐Vázquez Pablo , Enríquez‐Cabrera Alejandro , Leon‐Rojas Andrés F. , Martínez‐Bourget Diego , Lacroix Pascal G. , Tassé Marine , Mallet‐Ladeira Sonia , Farfán Norberto , Santillan Rosa , Ramos‐Ortiz Gabriel , Malval Jean‐Pierre , Malfant Isabelle 
Published: August 2022

AbstractOne monometallic and three bimetallic ruthenium nitrosyl (RuNO) complexes are presented and fully characterized in reference to a parent monometallic complex of formula [FTRu(bpy)(NO)]3+, where FT is a fluorenyl‐substituted terpyridine ligand, and bpy the 2,2’‐bipyridine. These new complexes are built with the new ligands FFT, TFT, TFFT, and TF‐CC‐TF (where an alkyne C≡C group is inserted between two fluorenes). The crystal structures of the bis‐RuNO2 and bis‐RuNO complexes built from the TFT ligand are presented. The evolution of the spectroscopic features (intensities and energies) along the series, at one‐photon absorption (OPA) correlates well with the TD‐DFT computations. A spectacular effect is observed at two‐photon absorption (TPA) with a large enhancement of the molecular cross‐section (σTPA), in the bimetallic species. In the best case, σTPA is equal to 1523±98 GM at 700 nm, in the therapeutic window of transparency of biological tissues. All compounds are capable of releasing NO⋅ under irradiation, which leads to promising applications in TPA‐based drug delivery.
Pyrimidopteridine‐catalyzed Photo‐mediated Hydroacetoxylation
Authors: Petrosyan Andranik , Zach Luisa , Taeufer Tobias , Mayer T. S. , Rabeah Jabor , Pospech Jola 
Published: August 2022

AbstractHerein we report a photo‐mediated formal addition of carboxylic acids to activated alkenes catalyzed by a pyrimidopteridine photoredox catalyst. The decarboxylation of aliphatic carboxylic acids upon single‐electron oxidation is countered in the presence of electron‐rich alkenes and a hydroacetoxylation is observed. Mechanistic proposals have been made based on CV measurements, competitive Stern‐Volmer quenching and EPR experiments. Evidence that tetra‐N‐substituted pyrimidopteridines function as dual photoredox and hydrogen atom transfer catalyst was supported by spectroscopic means.
Pd‐Catalyzed Aerobic Intermolecular 1,2‐Diamination of Conjugated Dienes: Regio‐ and Chemoselective Synthesis of Piperazines and 2‐Piperazinones
Authors: Liu Huikang , Li Yunyi , Yang Zehua , Ge Qianyi , Wu Zhengxing , Zhang Wanbin 
Published: August 2022

AbstractDinitrogen heterocycles are among the most important molecular structures, and the synthesis of these types of structures through intermolecular 1,2‐diamination of olefins is a direct and efficient method. However, the types of nitrogen sources are mostly derived from ureas or arylamines, and nitrogen sources from aliphatic amines are still limited due to their distinct electronic and steric effects. Herein, we report a palladium‐catalyzed aerobic intermolecular 1,2‐diamination of conjugated dienes, using ethanediamine and α‐amino amide derivatives as nitrogen sources respectively, for the synthesis of piperazines and 2‐piperazinones in good yields (up to 95 %) and with high regio‐ and chemoselectivities.
Elastin‐Hyaluronan Bioconjugate as Bioactive Component in Electrospun Scaffolds
Authors: Laezza Antonio , Pepe Antonietta , Bochicchio Brigida 
Published: August 2022

AbstractHyaluronic acid or hyaluronan (HA) and elastin‐inspired peptides (EL) have been widely recognized as bioinspired materials useful in biomedical applications. The aim of the present work is the production of electrospun scaffolds as wound dressing materials which would benefit from synergic action of the bioactivity of elastin peptides and the regenerative properties of hyaluronic acid. Taking advantage of thiol‐ene chemistry, a bioactive elastin peptide was successfully conjugated to methacrylated hyaluronic acid (MAHA) and electrospun together with poly‐D,L‐lactide (PDLLA). To the best of our knowledge, limited reports on peptide‐conjugated hyaluronic acid were described in literature, and none of these was employed for the production of electrospun scaffolds. The conformational studies carried out by Circular Dichroism (CD) on the bioconjugated compound confirmed the preservation of secondary structure of the peptide after conjugation while Scanning Electron Microscopy (SEM) revealed the supramolecular structure of the electrospun scaffolds. Overall, the study demonstrates that the bioconjugation of hyaluronic acid with the elastin peptide improved the electrospinning processability with improved characteristics in terms of morphology of the final scaffolds.
Improved survival in cervical cancer patients receiving care at National Cancer Institute–designated cancer centers
Authors: McDaniels‐Davidson Corinne , Feng Christine H. , Martinez Maria Elena , Canchola Alison J. , Gomez Scarlett Lin , Nodora Jesse N. , Patel Sandip P. , Mundt Arno J. , Mayadev Jyoti S. 
Published: August 2022

BackgroundLocally advanced cervical cancer (CC) remains lethal in the United States. We investigate the effect of receiving care at an National Cancer Institute–designated cancer center (NCICC) on survival.MethodsData for women diagnosed with CC from 2004 to 2016 who received radiation treatment were extracted from the California Cancer Registry (n = 4250). Cox proportional hazards regression models assessed whether (1) receiving care at NCICCs was associated with risk of CC‐specific death, (2) this association remained after multivariable adjustment for age, race/ethnicity, and insurance status, and (3) this association was explained by receipt of guideline‐concordant treatment.ResultsMedian age was 50 years (interquartile range [IQR] 41–61 years), with median follow‐up of 2.7 years (IQR 1.3–6.0 years). One‐third of patients were seen at an NCICC, and 29% died of CC. The hazard of CC‐specific death was reduced by 20% for those receiving care at NCICCs compared with patients receiving care elsewhere (HR = .80; 95% CI, 0.70–0.90). Adjustment for guideline‐concordant treatment and other covariates minimally attenuated the association to 0.83 (95% CI, 0.74–0.95), suggesting that the survival advantage associated with care at NCICCs may not be due to receipt of guideline‐concordant treatment.ConclusionsThis study demonstrates survival benefit for patients receiving care at NCICCs compared with those receiving care elsewhere that is not explained by differences in guideline‐concordant care. Structural, organizational, or provider characteristics and differences in patients receiving care at centers with and without NCI designation could explain observed associations. Further understanding of these factors will promote equality across oncology care facilities and survival equity for patients with CC.
DELLAs directed gibberellins responses orchestrate crop development: A brief review
Authors: Sarwar Rehman , Zhu Ke‐Ming , Jiang Ting , Ding Peng , Gao Yue , Tan Xiao‐Li 
Published: August 2022

AbstractGibberellins (GAs) are a pervasive group of diterpene phytohormones. They can dominate various aspects of plant development and modulate plant phenotypic plasticity by crosstalking with multiple phytohormones. Studies on GA signaling illustrate that master negative regulator DELLA proteins regulate GAs and nearly all phytohormones’ growth responses to sustain plant growth and defense under relentless biotic and abiotic stresses. The molecular mechanism of DELLA proteins in regulating GA‐sensitive growth in an integrated manner with multiple phytohormones became apparent recently. These studies describe the interaction of interaction DELLA proteins with a diverse group of transcriptional regulators and factors as well as nontranscriptional proteins in directing GA‐stimulated plant growth. In this review, we address the extensive recent work to delineate DELLA proteins and their interacting partners and summarize the latest evidence that DELLA proteins have a unique function in suppressing the GA‐related responses to sustain the tension among growth and defense.
Selective Oxidation of Glycerol into Formic Acid by Photogenerated Holes and Superoxide Radicals
Authors: Liu Meijiang , Liu Huifang , Li Ning , Zhang Chaofeng , Zhang Jian , Wang Feng 
Published: August 2022

AbstractPhotocatalysis is a promising technology for conversion of the glycerol into formic acid, but photocatalytic oxidation of C−C bonds in glycerol exhibits poor selectivity towards formic acid because the photogenerated radicals (e.g., hydroxyl radicals) further oxidize formic acid to CO2. In this work, a synergy of photogenerated holes and superoxide radicals that achieved the selective oxidation of glycerol into formic acid over the TiO2 catalyst was revealed. The charge separation of pristine TiO2 was improved with the aid of oxygen, which resulted in efficient hole oxidation of the C−C bonds in glycerol to formic acid. Surface active species were controlled to prevent being converted to hydroxyl radicals on TiO2 by controlling the oxygen and water contents, which solved the problem of formic acid peroxidation without sophisticated catalyst modifications. Mechanism studies suggested that glyceraldehyde and glycolaldehyde were the intermediates to generate formic acid. This work provides a green and efficient approach to produce formic acid as a liquid hydrogen carrier from bio‐based alcohols.
Highly Stable Iron‐ and Carbon‐Based Electrodes for Li‐Ion Batteries: Negative Fading and Fast Charging within 12 Min
Authors: Choi Wonyoung , Ha Jaeyun , Kim Yong‐Tae , Choi Jinsub 
Published: August 2022

AbstractLithium‐ion batteries (LIBs) with high energy density and safety under fast‐charging conditions are highly desirable for electric vehicles. However, owing to the growth of Li dendrites, increased temperature at high charging rates, and low specific capacity in commercially available anodes, they cannot meet the market demand. In this study, a facile one‐pot electrochemical self‐assembly approach has been developed for constructing hybrid electrodes composed of ultrafine Fe3O4 particles on reduced graphene oxide (Fe3O4@rGO) as anodes for LIBs. The rationally designed Fe3O4@rGO electrode containing 36 wt % rGO exhibits an increase in specific capacity as cycling progresses, owing to improvements in the active sites, electrochemical kinetics, and catalytic behavior, leading to a high specific capacity of 833 mAh g−1 and outstanding cycling stability over 2000 cycles with a capacity loss of only 0.127 % per cycle at 5 A g−1, enabling the full charging of batteries within 12 min. Furthermore, the origin of this abnormal improvement in the specific capacity (called negative fading), which exceeds the theoretical capacity, is investigated. This study opens up new possibilities for the commercial feasibility of Fe3O4@rGO anodes in fast‐charging LIBs.
Diverse stem cells for periodontal tissue formation and regeneration
Authors: Nagata Mizuki , English Jeryl D. , Ono Noriaki , Ono Wanida 
Published: August 2022

SummaryThe periodontium is comprised of multiple units of mineralized and nonmineralized tissues including the cementum on the root surface, the alveolar bone, periodontal ligament (PDL), and the gingiva. PDL contains a variety of cell populations including mesenchymal stem/progenitor cells (MSCs) termed PDLSCs, which contribute to periodontal regeneration. Recent studies utilizing mouse genetic models shed light on the identities of these mesenchymal progenitors in their native environment, particularly regarding how they contribute to homeostasis and repair of the periodontium. The current concept is that mesenchymal progenitors in the PDL are localized to the perivascular niche. Single‐cell RNA sequencing (scRNA‐seq) analyses reveal heterogeneity and cell‐type specific markers of cells in the periodontium, as well as their developmental relationship with precursor cells in the dental follicle. The characteristics of PDLSCs and their diversity in vivo are now beginning to be unraveled thanks to insights from mouse genetic models and scRNA‐seq analyses, which aid to uncover the fundamental properties of stem cells in the human PDL. The new knowledge will be highly important for developing more effective stem cell‐based regenerative therapies to repair periodontal tissues in the future.
Ambulatory haemodynamic‐guided management reduces heart failure hospitalizations in a multicentre European heart failure cohort
Authors: Dauw Jeroen , Sokolski Mateusz , Middleton Jennifer T. , Nijst Petra , Dupont Matthias , Forouzan Omid , Rothman Alexander M.K. , Ruschitzka Frank , Flammer Andreas J. , Mullens Wilfried 
Published: August 2022

AbstractAimsTo investigate the outcomes and associated costs of haemodynamic‐guided heart failure (HF) management with a pulmonary artery pressure (PAP) sensor in a multicentre European cohort.Methods and resultsData from all consecutive patients receiving a PAP sensor in Ziekenhuis Oost‐Limburg, University Hospital Zurich and Sheffield Teaching Hospitals NHS Foundation Trust before January 2021 were collected. Medication changes, total number of HF hospitalizations and HF related health care costs (composed of HF hospitalizations, outpatient cardiology visits and monitoring costs) were compared between the pre‐implantation and post‐implantation period at 3, 6, and 12 months. PAP evolution post‐implantation were grouped according to baseline mPAP ≥25 mmHg versus <25 mmHg and changes from baseline were analyzed via an area under the curve (AUC) analysis. A total of 48 patients received a PAP sensor (29 CardioMEMS and 19 Cordella devices) with a median follow‐up of 19 (13–30) months. Mean age was 71 ± 10 years, 25.0% were female, 68.8% had a left ventricular ejection fraction < 50%, median NT‐proBNP was 1801 (827–4503) pg/mL, and 89.6% were in NYHA class III. The number of diuretic therapy changes were non‐significantly increased after 3 months (49 vs. 82; P = 0.284) and 6 months (82 vs. 127; P = 0.093) with a significant increase noted after 12 months (118 vs. 195; P = 0.005). The mPAP AUC decreased by −1418 mmHg‐days for patients with a baseline mean PAP ≥ 25 mmHg. The number of HF hospitalizations was reduced for all patients after 6 (34 vs. 17; P = 0.014) and 12 months (48 vs. 29; P = 0.032). HF related health care costs were reduced from € 6286 to € 3761 at 6 months (P = 0.012) and from € 8960 to € 6167 at 12 months (P = 0.032).ConclusionHaemodynamic‐guided HF management reduces HF hospitalizations and HF related health care costs in selected HF patients amongst different European health care systems.
A New Family of Tropylium Ions: Tropone–Triarylborane Complexes
Authors: Kinoshita Ryo , Tomura Fumiya , Fujita Takeshi , Ichikawa Junji 
Published: August 2022

AbstractAir‐ and thermally stable tropone–triarylborane 1 : 1 complexes were synthesized in excellent yields by treating tropones, including benzo‐fused derivatives, with an equimolar amount of B(C6F5)3. NMR and X‐ray analyses and DFT calculations including nuclear independent chemical shift (NICS) and anisotropy of the induced current density (ACID) studies revealed that the tropone–triarylborane complexes have betaine structures consisting of tropylium and borate moieties and that their aromaticity depends on the number of fused benzene rings.
Catechol‐Functionalized Carbon Nanotubes as Support for Pd Nanoparticles: a Recyclable System for the Heck Reaction
Authors: Mercadante Alessandro , Campisciano Vincenzo , Morena Anthony , Valentino Laura , La Parola Valeria , Aprile Carmela , Gruttadauria Michelangelo , Giacalone Francesco 
Published: August 2022

AbstractCarbon nanotubes have been covalently functionalized with catechol moieties through the formation of the corresponding aryl radicals obtained by reacting 4‐aminocatechol with isoamyl nitrite. The functionalized multiwalled carbon nanotubes have been in turn used to immobilize Pd(II) ions on its surface forming catechol‐Pd complexes, which were reduced to Pd nanoparticles (NPs). The so‐obtained hybrid material has been characterized by means of thermogravimetric analysis coupled with differential scanning calorimetry (TGA‐DSC), X‐ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). This latter technique allowed to estimate the nanoparticle size (5.7±2.8 nm) whereas a palladium loading of 20.3 wt % has been found by inductively coupled plasma optical emission spectroscopy (ICP‐OES). The carbon nanotube‐catechol‐Pd hybrid was used as catalyst in two C−C coupling reactions, namely Suzuki and Heck reactions, resulting recyclable for at least 9 times in the latter process. During the reuse Pd nanoparticles increase their dimension to 19.3±11.7 nm.
Iron‐Based Imidazolium Salt as Dual Lewis Acid and Redox Catalyst for the Aerobic Synthesis of Quinazolines
Authors: Martos Mario , Pastor Isidro M. 
Published: August 2022

AbstractA low transition temperature mixture formed with 1‐butyl‐3‐(methoxycarbonylmethyl)imidazolium chloride and iron(III) chloride has proven to be an efficient catalyst for the synthesis of quinazolines following a sequence of condensation‐cyclization‐oxidation reactions. The protocol is simple and effective for coupling 2‐acylanilines and benzylamines to form nitrogen containing heterocycles with moderate to excellent yields (up to 93 %), being possible to perform the reaction in preparative scale. The functionalized imidazolium salt is crucial for the activation of the reagents under solvent‐free conditions, and the presence of iron in the catalyst mediates the oxidation step with atmospheric oxygen. These features make the presented procedure better, from an environmental point of view, than other processes previously described. For this comparison, different “green” metrics have been used, such as atom economy, stoichiometric factor, reaction mass efficiency, E‐factor, and EcoScale.
D‐Limonene for regulating metabolism‐associated fatty liver disease (MAFLD) and analysis of the TCM constitution: A protocol for an exploratory, randomized, double‐blind, placebo‐controlled trial (DL‐MAFLD‐TCM)
Authors: Lv Wenwen , Tan Xiyang , Chen Xiaochen , Hu Tingting , Jiang Jiayuan , Li Qiang , Chen Xiao‐yun , Tan Hongsheng , Qian Biyun 
Published: August 2022

AbstractThe protocol describes the first study evaluating the treatment of metabolism‐associated fatty liver disease (MAFLD). MAFLD, formerly known as nonalcoholic fatty liver disease, was renamed by an internationally renowned liver disease expert group in 2020. MAFLD contains three types: overweight/obesity (A type), type 2 diabetes mellitus (B type), or evidence of metabolic dysregulation (C type). There is a lack of effective therapeutic drugs. We found that D‐limonene, a food additive in China, has potential activity on the A type of MAFLD through animal studies. Then, we designed an exploratory, single‐center, double‐blind, placebo‐controlled, randomized clinical trial for the evaluation of limonene capsules (marketed product in China) on regulating A type of MAFLD and analysis of the TCM constitution (DLMAFLD‐TCM). A total of 60 patients with A type of MAFLD will be randomly assigned to a treatment arm with (n = 30) or without (n = 30) Food Frontiers for Review Only limonene (placebo) for 12 weeks. The primary end point will be assessed at two end points combined for A type: changes in the controlled attenuation parameter and body mass index at baseline and 12 weeks after administration. The study procedures and informed consent form were approved by the hospital. We detail the protocol and the statistical analysis plan of the trial prior to study completion, which is for further study. This trial is registered in the Chinese Clinical Trial Registry (ChiCTR2000035888).