bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Specialization of S-Adenosylmethionine Synthases Links Phosphatidylcholine to Mitochondrial Function and Stress Survival
Authors: Munden Athena L. , Lui Dominique S. , Higgins Daniel P. , Fanelli Matthew J. , Ngyuen Thien-Kim , Edwards Katherine M. , Ericsson Maria , Godbole Adwait A. , Haley John A. , Lewis Caroline , Spinelli Jessica B. , Harrison Benjamin , Raftery Daniel , Djukovic Danijel , Promislow Daniel E.L. , Miller Dana L. , Walker Amy K. 
Published: February 2025

AbstractS-adenosylmethionine (SAM), produced by SAM synthases, is critical for various cellular regulatory pathways and the synthesis of diverse metabolites. Studies have often equated the effects of knocking down one synthase with broader SAM-dependent outcomes such as histone methylation or phosphatidylcholine (PC) production. Humans and many other organisms express multiple SAM synthases. Evidence inCaenorhabditis elegans, which possesses four SAM synthase genes, suggest that the enzymatic source of SAM impacts its function. For instance, loss ofsams-1leads to enhanced heat shock survival and increased lifespan, whereas reducingsams-4adversely affects heat stress survival. Here, we show that SAMS-1 contributes to a variety of intermediary metabolic pathways, whereas SAMS-4 is more important to generate SAM for methylation reactions. We demonstrate that loss ofsams-1exerts age-dependent effects on nuclear-encoded mitochondrial gene expression, mitochondrial metabolites, and may induce mitophagy. We propose a mechanistic model where reduced SAM from SAMS-1 acts through PC to impact mitochondria, thereby enhancing survival during heat stress.
Urban rail transit in heritage – rich cities: exploring the unique project risks
Authors: Ma Ying , Bhatt Nava Raj , Wu Qianlong , Pokharel Mandeep 
Published: February 2025

PurposeThis study introduces the heritage city risk dimension of the urban rail transit (URT) projects. It aims to identify the risk factors affecting URT projects within the unique context of heritage-rich cities, exploring their interrelation and evaluating critical factors.Design/methodology/approachThe research adopts a multi-case exploratory study to identify the unique challenges faced by URT projects in heritage-rich environments, followed by a comprehensive risk assessment framework integrating Fuzzy Decision-Making Trial and Evaluation Laboratory (DEMATEL), Analytic Network Process (ANP) and Risk Interaction Network (RIN) analysis to assess identified risks in the context of Kathmandu Valley. Additionally, a risk response action is simulated using RIN analysis.FindingsAbout 16 risk factors were identified from the case studies and evaluated using the proposed risk assessment methodology. The study reveals a highly interconnected risk environment, with heritage impact-related factors exerting the strongest causative influence on cost and social engagement factors. Community opposition (R8) shows the highest betweenness centrality, indicating its central position in risk propagation across the network. Cost-related risk, social demand contingency (R2) ranked as the most critical. Simulations of a targeted risk avoidance strategy showed that addressing only three key high-betweenness centrality factors (R5, R8 and R15) reduced overall risk interactions by 46%, simplifying the risk network, reducing project complexity and improving manageability.Practical implicationsThe findings emphasize that project managers, urban planners and policymakers should integrate heritage preservation concerns when planning and executing URT projects in heritage-rich cities. Moreover, the research highlights that effective community engagement serves as a key strategy for reducing risk propagation and plays a crucial role in overall project risk management.Originality/valueThe study contributes to the underexplored context of URT projects in heritage-rich cities, providing a comprehensive risk management framework for identifying and assessing project risks intersecting with urban development imperatives and heritage conservation objectives.
Relation between ethical sales behaviour and switching costs: a mediation of trust in medical schemes
Authors: Mofokeng Thabang Excellent 
Published: February 2025

Purpose
This study aims to assess how ethical sales behaviour affects switching costs typology, mediated by trust and moderated by brand affiliation, monthly contributions and the number of dependent beneficiaries in medical schemes in South Africa.

Design/methodology/approach
A quantitative study targeted a non-probability judgement sample of 250 main members of medical schemes, elicited near health-care facilities in South Africa’s Gauteng province. Data was collected in a face-to-face survey and analysed using structural equation modelling on AMOS version 29 and PROCESS procedure for Statistical Package of Social Science release 2.041.

Findings
The results show that ethical sales behaviour negatively affects trust and positively affects evaluation, monetary and personal relational loss costs. Trust positively affects personal relational loss costs, economic risk, evaluation, monetary and benefit loss costs. Moreover, trust mediates the effect of ethical sales behaviour on evaluation, monetary and personal relational loss costs. Finally, the number of dependent beneficiaries, monthly contributions and brand affiliation significantly moderate these interactions.

Originality/value
The paper validates the application of commitment-to-trust theory in mediating how the effects of the general theory of marketing ethics on switching costs typology differ according to the number of dependent beneficiaries, monthly contributions and brand affiliation with medical schemes.
Hotel employees’ attitudes towards multitasking: scale development and validity testing
Authors: Ayyildiz Tuğrul , Koc Erdogan , Baykal Muhammed , Yazıcı Ayyıldız Ahu 
Published: February 2025

PurposeThere is an increasing multitasking expectation from tourism and hospitality managers, including hotel managers. There has been a significant amount of research investigating various aspects of multitasking. Yet, there is no scale to measure the willingness and tendency of hotel employees to engage in multitasking.Design/methodology/approachA rigorous scale development process was followed. After a pre-test with 218 hotel employees, data were collected from 646 employees in tourist destinations in Türkiye, including Kusadasi, Antalya, Ankara, Bodrum, Didim, Istanbul, Fethiye and Marmaris. The nomological validity of the scale was tested by examining multitasking’s effect on role clarity.FindingsA multitasking scale with five dimensions (accomplishment, customer satisfaction, difficulty, fear and workload) and 16 items has been developed to determine the multitasking orientations of hotel employees. It was also discovered that multitasking was a good predictor of employee role clarity.Practical implicationsThe scale enables hotel managers to evaluate multitasking ability and willingness during recruitment and address challenges like performance, motivation and stress. It supports HR adjustments to enhance employee and customer satisfaction.Originality/valueExisting multitasking scales, primarily focused on media multitasking, are not comprehensive for employees, and no specific scale exists for hotel employees who frequently multitask. This scale offers valuable insights for HRM and service quality improvement. Forced multitasking, driven by fear of career jeopardy, can lead to negative outcomes such as role ambiguity, reduced performance, motivation and job satisfaction.
Beyond reality: examining consumer intention to embrace metaverse within hospitality
Authors: Azhar Mohd , Khan Safdar , Kirmani Mohd Danish , Mustafa Farhan , Khan Fateh Mohd 
Published: February 2025

PurposeThis study intends to unmask the antecedents of metaverse adoption intention (MAI) within the Indian hospitality industry. To achieve this objective, we extended the “unified theory of acceptance and use of technology” (UTAUT) by integrating additional constructs: “perceived cyber risk” (PCR), “trust” (TR), “personal innovativeness in IT” (PIT) and “hedonic motivation” (HM).Design/methodology/approachA quantitative research methodology was employed, utilizing data gathered through an online survey disseminated via Google Forms to evaluate the constructs of the study. Convenience and snowball sampling were used, and the proposed relationships were analyzed using “partial least squares structural equation modeling” (PLS-SEM).FindingsThe study presents a robust model explaining MAI among Indian hospitality consumers, with a high R² of 81%, indicating strong predictive relevance. Core UTAUT constructs (PE, EE, SI and FC) and additional constructs (TR, HM and PIT) positively influence MAI, while PCR negatively impacts it.Research limitations/implicationsThis research enhances the existing body of knowledge by providing a deeper insight into metaverse adoption among hospitality consumers in India. The proposed framework provides a more nuanced perspective on metaverse adoption, extending beyond conventional technological factors.Originality/valueThis study is distinctive in its integration of four additional constructs- PCR, TR, PIT and HM- into the original UTAUT model, thereby addressing a gap in the existing literature. Furthermore, it advances the understanding of the metaverse by identifying key antecedents influencing MAI among Indian hospitality consumers.
Rapid developments in the emerging hybrid sukuk market: a case of Ijara-Murabaha sukuk, perceived promising reforms in oil sectors of Pakistan
Authors: Kashif Uzma , Arif Unbreen , Saad Hafiz Muhammad , Siddiqui Ahmed Ali 
Published: February 2025

Purpose
This research aims to explore the role played by Ijara-Murabaha Sukuk in attracting foreign direct investment (FDI) that adheres to Shariah principles into Pakistan’s oil sector. It focuses on the difficulties faced by the country in terms of payment for oil procurement. It highlights the recent collaboration with ARAMCO, Saudi Arabia’s national oil company, to establish the Gwadar Refinery Project. This project aims to enhance oil production, reduce costs and increase storage capacity.

Design/methodology/approach
Data was collected from 379 investors who participate in Ijara-Murabaha Sukuk through a questionnaire designed to evaluate how trade finance solutions, sustainability practices, transparency measures and governance structures impact FDI that comply with Shariah principles. The study also considers the moderating role of market conditions on these factors. Smart PLS 4 software was used to analyze their influence on creating an environment conducive to Shariah-compliant FDI.

Findings
The findings reveal that if the company prioritizes shariah-compliant foreign direct investment over conventional due to underlying productive activities ensuring economic growth as well as strong compliance mechanisms ensuring transparency, the multifaceted challenges associated with oil procurement, circular deficit, foreign exchange reserves and transparency problems can be solved. The groundbreaking analysis from this study will guide the major stakeholders while developing policies to convert the most expensive and massive budget deficit sector into a contributing sector of the economy.

Originality/value
This is a pioneering study on the application of Ijara-Murabaha Sukuk to resolve the problem of circular deficit of oil sectors of Pakistan by issuing 51% Ijara Sukuk for enhancing the capacity for the storage of oil and producing the oil from imported crude oil. 49% murabaha sukuk for importing crude oil. Successful implementation of the Shariah-compliant ARAMCO project can open the door to foreign direct investment for Pakistan and the other third economies, meeting the “Reducing Poverty of SDGs.”
The Evolution of Emergency Planning at Kent State University, 1970–2020
Authors: Eckert Erica 
Published: February 2025

ABSTRACTThe shootings at Kent State on May 4, 1970, shocked people all over the world and were a disaster for the university. To resume operations and rebuild its reputation, Kent State University turned to emergency planning decades before it was standard practice in higher education. Scholars of emergency management assert that innovation in the field often arises in response to disasters (Rubin, 2020) and that examining its history offers valuable insights (Butler, 2020; Phillips et al. 2012). The Kent State shootings served as a focusing event (Rubin, 2020) that opened a policy window (Kingdon, 1995) within the institution. Drawing on archival documents and oral histories, this historical case study examines how Kent State created their emergency plan through the lens of Kingdon's multiple streams framework. It presents a rare glimpse of an early example of emergency planning in higher education. This paper situates Kent State's actions within the broader context of emergency planning in higher education, explains how its first plan was developed and what it contained, and concludes with a brief description of recent emergency planning at Kent State.
Opioid‐induced androgen deficiency in men: Prevalence, pathophysiology, and efficacy of testosterone therapy
Authors: Kafel Hussein , Braga‐Basaria Milena , Basaria Shehzad 
Published: February 2025

AbstractBackgroundOpioid analgesics are frequently prescribed for the treatment of chronic pain and are a common cause of male androgen deficiency. Despite its high prevalence, this adverse effect of chronic opioid use remains underappreciated by clinicians. As a result, androgen deficiency remains underdiagnosed and likely undertreated. This focused review discusses the expanding literature on opioid‐induced androgen deficiency and the efficacy of testosterone therapy, with a particular focus on its anti‐nociceptive effects.MethodsOriginal and review articles on opioid‐induced male androgen deficiency published from 1950 through June 2024 were retrieved from PubMed using the key terms “opioids,” “hypogonadism,” “low testosterone,” and “testosterone therapy.” References within the retrieved publications were also researched.ResultsOpioids suppress the gonadal axis mainly by inhibiting GnRH synthesis and secretion. The prevalence of opioid‐induced androgen deficiency in men varies between 20% and 80% and is influenced by the type of opioid used, duration of exposure, age of the cohort, and how low testosterone was defined. Limited data from clinical trials suggest that testosterone therapy improves libido, body composition, and certain domains of quality of life. Early evidence also suggests that testosterone has anti‐nociceptive properties, confirming findings from preclinical and population studies.ConclusionChronic opioid use is a common but underappreciated cause of androgen deficiency in men. There is a need to raise awareness among clinicians regarding this adverse effect of opioid use. Testosterone therapy could be considered in men with unequivocal androgen deficiency after a thorough clinical evaluation. Ongoing clinical trials will shed further light on the efficacy of testosterone therapy, particularly regarding its anti‐nociceptive effects.
Association of oral contraceptives and risk of endometrial cancer: A systematic review and meta‐analysis
Authors: Harajka András , Hercsik Tímea , das Virgens Isabel Pinto Amorim , Máthé Izabella , Tornyossy Zsófia , AlFarwi Ali , Meznerics Fanni Adél , Kiss‐Dala Szilvia , Fehérvári Péter , Nagy Rita , Bánhidy Ferenc , Majoros Attila , Valent Sándor , Hegyi Péter , Ács Nándor 
Published: February 2025

AbstractIntroductionAlthough the relationship between the use of oral contraceptives and reduced endometrial cancer risk has now long been established, the need for female patients to be informed on this matter based on the latest results of scientific research remains. To help the evidence‐based decision‐making of women when choosing contraception methods, we aimed to provide them with an up‐to‐date overview and summary of past and recent findings on the association between the use of oral contraceptives and endometrial cancer risk.Material and MethodsThis study was registered in PROSPERO: CRD42022379871. PubMed, Embase, and Cochrane Library databases were searched on the December 5, 2022, to identify eligible articles. We included all experimental and observational studies that reported the number of users and non‐users of oral contraceptives among patients diagnosed or not with endometrial cancer. Data were extracted, and random‐effects meta‐analysis was performed to obtain summary odds ratios (OR) with 95% confidence intervals (CI). Heterogeneity across studies was assessed using Higgins & Thompson's I2 statistic.ResultsFifty‐six studies were eligible for qualitative synthesis, of which twenty‐five were eligible for quantitative analysis. The use of oral contraceptives was inversely associated with the odds of having endometrial cancer (OR = 0.61, CI: 0.46–0.80). The long‐term use of oral contraceptives led to the greatest odds reduction in having endometrial cancer (≥10 years: OR = 0.31, CI: 0.13–0.70), while shorter periods were also associated with a significant decrease in these odds, although to a lesser extent (≥5 years: OR = 0.39, CI: 0.23–0.64; <5 years: OR = 0.66, CI: 0.48–0.91).ConclusionsThe administration of oral contraceptives is time dependently associated with lower odds of having endometrial cancer, suggesting a protective association between the use of oral contraceptives and endometrial cancer.
Where and why do women lead? The importance of leadership for private profit versus purpose beyond profit
Authors: Kinahan Mary M. , Bosak Janine , Eagly Alice H. 
Published: February 2025

AbstractTo examine how personal preferences and social norms can influence women's occupancy of organizational leadership roles, this research compared leadership roles that differ in their stakeholder focus on private profit (PP), producing gains for shareholders, or on purpose beyond profit (PBP), producing gains for the community and society. Consistent with the greater representation of women leaders in non‐profit than for‐profit sectors, the research showed that men preferred and were expected to prefer leader roles focussed on PP and women preferred and were expected to prefer leader roles focussed on PBP. These differing preferences and normative expectations reflected divergent life goals, whereby men favoured agentic goals and women favoured communal goals, with social norms reflecting this gender difference. This research thus showed how the communal and agentic life goals of women and men are linked to their personal role preferences and to normative expectations about leader role occupancy, thus fostering gender segregated leader roles.
Xiao‐Chai‐Hu‐Tang Ameliorates Depressive Symptoms via Modulating Neuro‐Endocrine Network in Chronic Unpredictable Mild Stress‐Induced Mice
Authors: Feng Ying , Wang Wenkai , Zhang Yingru , Feng Yuanyuan , Zhao Yiyang , Zhang Zhaozhou , Wang Yan 
Published: February 2025

ABSTRACTObjectiveXiao‐Chai‐Hu‐Tang (XCHT) has been demonstrated to exert an antidepressant effect during long‐term clinical practices. However, the potential mechanisms of XCHT remain unknown. This study aims to investigate the effect of XCHT on chronic unpredictable mild stress‐induced mice with depressive‐like behaviors and to explore the underlying mechanisms.MethodsThe active compositions and potential related targets of XCHT in the brain were obtained through UPLC‐Q‐TOF‐MS, network pharmacology, and bioinformatics analyses, verified by experimental validation. Then, the protein–protein interaction (PPI), Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses, and molecular docking were used to predict the core targets and mechanisms of XCHT on depression. After being treated with XCHT standard decoction, based on enzyme‐linked immunosorbent assay (ELISA), non‐targeted metabolism, targeted LC–MS analyses, RNA‐seq, quantitative RT‐PCR, immunofluorescence, and western blotting were determined to clarify the mechanism of XCHT in the treatment of anxiety and depression disorder.ResultsIn total, 166 active ingredients and 525 related targets of XCHT were detected and selected from the network databases. The inflammatory response and metabolism of neurotransmitters were the main related signaling pathways predicted by KEGG enrichment analyses. Behavioral testing shows that XCHT has antidepressant effects, and untargeted metabolomic studies showed it significantly reduced levels of the neurotoxic substance quinoline acid. Combining the results of molecular docking, RNA‐seq, and western blot revealed that XCHT regulated nerve regeneration via BDNF/TrkB/CREB and PI3K/AKT signaling pathways. Immunofluorescence analysis revealed that XCHT downregulated the chronic stress‐induced activation of microglia and astrocytes in the hippocampus.ConclusionXCHT exerts antidepressant functions by modulating neuroinflammation and neuroregeneration.
Adaptive Evolution of Freezing Tolerance in Oaks Is Key to Their Dominance in North America
Authors: Fontes Clarissa G. , Meireles Jose Eduardo , Hipp Andrew L. , Cavender‐Bares Jeannine 
Published: February 2025

ABSTRACTFreezing tolerance plays a pivotal role in shaping the distribution and diversification of organisms. We investigated the dynamics of adaptation to climate and potential trade‐offs between stem freezing tolerance and growth rate in 48 Quercus species. Species from colder regions exhibited higher freezing tolerance, lower growth rates and higher winter‐acclimation potential than species from warmer climates. Despite an evolutionary lag, freezing tolerance in oaks is closely aligned with its optimal state. Deciduous species showed marked variability in freezing tolerance across their broad climatic range, while evergreen species, confined to warm climates, displayed low freezing tolerance. Annual growth rates were constrained in all deciduous species, but those that evolved in warm latitudes lost freezing tolerance, precluding a trade‐off between freezing tolerance and growth. We provide evidence that the capacity to adapt to a wide range of thermal environments was critical to adaptive radiation and the current dominance of the North American oaks.
Warming During Different Life Stages has Distinct Impacts on Host Resistance Ecology and Evolution
Authors: Li Jingdi , Smith Cameron A. , Chen Jinlin , Bates Kieran A. , King Kayla C. 
Published: February 2025

ABSTRACTClimate change is increasing extreme heating events and the potential for disease outbreaks. Whether hosts can adapt to infection with rising temperatures is important for forecasting species persistence. We tested whether warming—at different host life stages—affects the ecological and evolutionary dynamics of resistance in Caenorhabditis elegans infected by a wild bacterial pathogen. We competed resistant and susceptible genotypes across 10 passages and tracked the spread of resistance in the population. Infection and prolonged warming strongly selected for the resistant genotype. Warming during host development induced plastic defences against infection, reducing the selective pressure for costly genetic‐based resistance. Resistance was lost under ambient temperatures and periodic warming. Selection for resistance was likely weakened at ambient temperatures by the dilution effect, whereby the resistant genotype reduced pathogen transmission. Evolutionary dynamics of resistance depend on the balance among pathogen virulence, costs of genetic‐based resistance, the dilution effect and plastic defences induced by temperature stress.