bluuebunny/crossref_metadata_2025_split huggingface dataset:
Left ventricle accessory antero-septal papillary muscle: an echocardiography and cardiac MRI case-series report
Authors: Angheloiu George O. , Biederman Robert W. 
Published: September 2022

Abstract

Background. We studied by means of echocardiography and cardiac MRI (CMR) the occurrence of an accessory papillary muscle that unites mostly the left ventricle (LV) apex with the basal antero-septum in the immediate vicinity of left ventricle outflow tract (LVOT) in patients with and without hypertrophic cardiomyopathy (HOCM).

Methods. We included all good quality echocardiography and CMR studies as reviewed by two cardiologists and assessed the occurrence of a contractile papillary muscle situated between the LV apex and antero-septum.

Results. A contractile accessory papillary muscle situated between the LV apex and the anteroseptum was seen in 100% of HOCM patients and 62% of control patients (p=0.05) in the CMR images acquired from a total of 9 HOCM and 13 control patients. The same structure was observed in 241 patients representing 69.5% of all-comers echocardiography studies. The age was 69 ± 17 years on average in the echocardiography arm, patients harboring the antero-septal accessory muscle being older (71.6 + 15.7 years old vs 63.5 ± 18.1 for those without, p=0.0005). We exemplify this structure by parasternal long axis still echocardiography images and clips from 24 patients and CMR SSFP still images and a clip from two HOCM patients and one control.

Conclusion. A contractile accessory papillary muscle was observed in more than half of the all-comer echocardiography studies, and in all HOCM patients in the CMR arm. Further research is needed to fully characterize the anatomical and physiological significance as well as the possible structural interventional consequences of this structure attaching in the immediate vicinity of the LVOT in HOCM and control patients.
Ventriculoperitoneal shunt failure due to raised intra-abdominal pressure: A case report and review of the literature
Authors: Hmimidi Dounia , Ariai Shafie , Reithmeier Thomas 
Published: September 2022

Background:
Ventriculoperitoneal (VP) shunt implantation is the standard neurosurgical procedure to treat hydrocephalus for various reasons. Its function depends on the differential pressure between the ventricular space and the peritoneal cavity. Correct functioning of cerebrospinal fluid (CSF) valves requires a gradient of pressure between the ventricular and the abdominal cavity. Any reason that disrupts this balance can result in dysfunction of the system. Increased intra-abdominal pressure (IAP) may be a reason to induce shunt failure by decreasing CSF drainage from the ventricular system to the peritoneal cavity.

Case Description:
We report a case of repeated VP shunt failure because of constipation and successful conservative management by lowering IAP without surgical revision of the VP shunt system and reviewed the relevant literature.

Conclusion:
Increased IAP for a variety of reason should always be considered as a possible reason for shunt failure that can often be treated conservatively and therefore can reduce unnecessary shunt revision surgery.
The Relationship Between Audit Services and Non-Audit Actuarial Services in the Auditor’s Report
Authors: Abass Zeina Khdier , Flayyih Hakeem Hammood , Hasan Sarah Isam 
Published: September 2022

Purpose: In view of the trend toward using international financial reporting standards when generating financial statements, we looked at the interaction between audit services and non-audit services for auditors in the context of actuarial services for insurance firms. CPAs are authorized to work in banks and insurance businesses, but those with a practicing license obtained after earning a higher academic degree are not.
Design/methodology/approach: A small number of auditing firms control the decisions issued by the Iraqi Accountants Association, monopolizing audit services in banks and insurance businesses. In the case of actuarial services used in reserve estimation, they are credited to an external party's account without any verification of the Reliability of the reserve estimation procedure.
Originality/value: In addition to audit services, a scale has been developed to examine the auditors' non-audit actuarial services. The financial reporting rules for insurance contracts 17 and the examinations for acquiring an actuarial certificate in the United States of America are used to create this scale.
Findings: The findings show that there is no substantial relationship between the two services supplied, and we recommend that the actuarial services be audited by specialist international companies that support the auditors' judgment on the computation of expected reserves in the financial accounts. Conducting specialist courses in the actuarial profession, and obtaining this credential is a requirement for auditing insurance companies.
Can high COVID-19 vaccination rates in adults help protect unvaccinated children? Evidence from a unique mass vaccination campaign, Schwaz/Austria, March 2021
Authors: Winner Hannes , Kimpel Janine , Krammer Florian , von Laer Dorothee , Paetzold Jörg 
Published: September 2022

Background
After an outbreak of the SARS-CoV-2 Beta variant in the district of Schwaz/Austria, vaccination with Comirnaty vaccine (BNT162b2 mRNA, BioNTech-Pfizer) had been offered to all adult inhabitants (≥ 16 years) in March 2021. This made Schwaz one of the most vaccinated regions in Europe at that time (70% of the adult population took up the offer). In contrast, all other Austrian districts remained with low vaccine coverage.

Aim
We studied whether this rapid mass vaccination campaign provided indirect protection to unvaccinated individuals such as children (< 16 years) living in the same district.

Methods
To study the effect of the campaign we used two complementary approaches. We compared infection rates among the population of children (< 16 years) in Schwaz with (i) the child population from similar districts (using the synthetic control method), and (ii) with the child population from municipalities along the border of Schwaz not included in the campaign (using an event study approach).

Results
Before the campaign, we observed very similar infection spread across the cohort of children in Schwaz and the control regions. After the campaign, we found a significant reduction of new cases among children of −64.5% (95%-CI: −82.0 to −30.2%) relative to adjacent border municipalities (using the event study model). Employing the synthetic control method, we observed a significant reduction of −42.8% in the same cohort.

Conclusion
Our results constitute novel evidence of an indirect protection effect from a group of vaccinated individuals to an unvaccinated group.
Disfunção Sexual Persistente e Antidepressivos Inibidores Seletivos da Recaptação da Serotonina: Mito ou Realidade?
Authors: Marinho Figueiredo Carlos José , Silva Castro Faria Freitas José Diogo , Ferreira Maria do Céu 
Published: September 2022

Os antidepressivos inibidores seletivos da recaptação da serotonina são psicofármacos frequentemente utilizados na prática clínica pelas especialidades de Medicina Geral e Familiar e de Psiquiatria no tratamento de perturbações depressivas e de ansiedade. As elevadas prescrições desta classe de antidepressivos resultam do seu concomitante perfil de eficácia, segurança e tolerabilidade.É clinicamente consensual que esta classe farmacológica pode interferir nas várias fases da resposta sexual durante o tratamento antidepressivo. No entanto, têm sido reportados cada vez mais casos na literatura em que a disfunção sexual não é reversível após a suspensão do fármaco, configurando uma nova entidade clínica persistente, cujo substrato patofisiológico se encontra presentemente sob intensa investigação científica. Rever a literatura recentemente publicada neste âmbito e consciencializar os clínicos para esta nova entidade revela-se uma prioridade com potenciais implicações, particularmente ao nível da abordagem de patologias psiquiátricas tão prevalentes na sociedade atual.
ORTA ÖĞRETİM ÖĞRENCİLERİNİN MEKÂNSAL DÜŞÜNME BECERİLERİNİN İNCELENMESİ
Authors: SERİNCİ Hüseyin , ÖZDEMİR Nevin 
Published: September 2022

ÖZET
Çalışmanın amacı, orta öğretim kurumlarının 9 ve 12. Sınıf düzeyinde öğrenim gören öğrencilerin mekânsal düşünme becerilerinin incelenmesidir. Araştırma genel tarama modelinde nicel bir durum çalışmasıdır. Çalışma örneklemi, Çorum İli Merkez İlçesinde yer alan sosyal bilimler, fen, Anadolu ve meslek liseleri gibi farklı orta öğretim kurumlarında 2020-2021 eğitim öğretim yılında öğrenim gören, 400 kişilik öğrenci grubundan oluşmaktadır. Çalışma örneklemi tabakalı tesadüfi örnekleme yöntemi ile belirlenmiştir. Örneklem tabakalarını lise türleri oluşturmakta olup, bu tabakalardan örneklemin seçimi rastgele veya tesadüfü örnekleme ile yapılmıştır. Veri toplama aracı olarak Google formlar aracılığı ile hazırlanmış bir anket formu kullanılmıştır. Anketin birinci bölümünde sınıf, lise türü, cinsiyet gibi demografik sorular; ikinci bölümünde ise Mekânsal Düşünme Beceri Testi (MDBT) yer almaktadır. Bu anket formu pandemi koşulları nedeniyle çevrimiçi olarak öğrencilere gönderilmiştir. MDBT’nin yapı geçerliliği açıklayıcı faktör analizi (AFA) ve doğrulayıcı faktör analizi ile de teyit edilmiştir ve MDBT’nin lise öğrencilerinin mekânsal düşünme becerilerini ölçmek için kullanılabilecek geçerli ve güvenilir bir ölçek olduğuna karar verilmiştir. Verilerin analizinde demografik değişkenlerin MDBT puanları üzerindeki etkisini incelemek için veri yapısına göre Mann-Whitney-Wilcoxon (MWW) veya Kruskal-Wallis testleri uygulanmıştır. Analiz sonuçları MDBT puanları üzerinde eğitim görülen orta öğretim türü, sınıf düzeyi, LGS puanı ile coğrafya sınav puanı değişkenlerde gruplar arasında istatistiksel olarak anlamlı farklılık olduğunu göstermiştir.
Early concepts of nutrition, digestion, diseases of the gastrointestinal tract and their treatment: mysticism, astrology, bloodletting, and leeches
Authors: Gubergrits N. B. , Byelyayeva N. V. , Linevska K. Y. 
Published: September 2022

The secrets that veiled alchemy with mysticism were passed down from the members of the fraternal order associations to the physicists and pharmacists, and are still preserved to a certain extent among these professionals. Their preparations were exotic and included a wide range of medicines to treat many diseases. Thus, the so‑called «golden solution», presented as a universal cure, was marketed under the name of the «Solar elixir».In ancient times, presence of parasites, such as worms or their eggs, was one of the objective signs of the disease. Their revealing led to conclusions about the devil’s possession as a result of sin. Thus, treatment included not only extraction of parasites through the anus or skin ulcers but also the prayers and potions to exorcise evil spirits.While cosmology, divination and biblical prophecy dominated the assessment of health status and were used to predict the likelihood of a successful outcome of treatment, the results of research by anatomists and physiologists of the 16th and 17th centuries made it possible to give rise to an understanding of the relationship between body structure and function. The application of the principle that structure governs function, while function is influenced by structure according to the concept of total integration of the organism allowed the researchers of that time to unravel some of the mysteries of the organism and led to certain advances in the medical field.Medical bloodletting was applied in almost all cultures and societies. It was based on the concept that the removal of a certain amount of blood ensures a faster recovery of the patient in several diseases. There were three main techniques of bloodletting: phlebotomy — opening a vein to let blood out; cupping, which was used in young, elderly and weak patients who could not tolerate phlebotomy; the use of leeches. However, leeches were the most popular. Anticoagulants secreted by the leech into the blood slow down healing and scarring. This property is especially useful for repairing damaged tissues without scarring, and therefore is of particular interest for plastic surgery.
Wound closure with a mesh and liquid tissue adhesive (Dermabond Prineo) system in pediatric spine surgery: a prospective single-center cohort study incorporating parent-reported outcome measures
Authors: Stricker Sarah , Eberhard Noëmi , Licci Maria , Greuter Ladina , Zweifel Christian , Guzman Raphael , Soleman Jehuda 
Published: September 2022

OBJECTIVE
Wound healing can be challenging in children undergoing spine surgery for neurological conditions due to a high risk of cerebrospinal fluid (CSF) leakage and wound infection. In adults, use of the Dermabond Prineo (DP) skin closure system, which consists of both tissue adhesive glue and a self-adhesive mesh, for wound closure of medium-length surgical incisions has been reported. The aim of this study was to investigate the efficiency and cosmetic outcome of DP for wound closure in extra- and intradural pediatric neurological spine surgery.

METHODS
In this prospective cohort study, 47 children underwent 50 spine procedures using DP for wound closure between 2018 and 2022 at a single institution. Patient demographic and surgical data were collected. The primary outcome was revision surgery for wound healing disorders, while secondary outcomes were infections, minor wound healing disorders, and both physician and parental satisfaction (parent-reported outcome measures [PROMs]) at last follow-up.

RESULTS
Among 50 spinal (45 intra- and 5 extradural) interventions, 1 patient (2%) underwent revision surgery for a cutaneous CSF fistula and pseudomeningocele. Minor wound healing disorders occurred after 16 surgeries, which did not require surgical wound revision and resolved completely. No allergic reactions to DP or surgical site infections within 30 days were observed. The parents and the medical team described wound care as significantly facilitated since wound dressing changes were not needed. Three families (6.4%) encountered difficulties in wound care, and 46 (97.9%) were satisfied with DP. The cosmetic outcome based on PROMs was excellent, with a mean score of 8 (IQR 2) on a scale from 1 to 10. At long-term follow-up, a mean of 11.3 ± 10.7 months after surgery, physicians rated the cosmetic outcome on the visual analog scale (median score 9, IQR 1) and Hollander scale (median score 6, IQR 1). The outcomes were similar among the different pathologies and age groups and did not differ in patients with and without syndromic malformations.

CONCLUSIONS
The application of DP is simple, enables good patient comfort, facilitates both professional and parental wound care, and leads to excellent cosmetic results. DP possibly aids in the reduction of postoperative CSF leakage and infections after pediatric neurological spine surgery.
Rod fractures in thoracolumbar fusions to the sacrum/pelvis for adult symptomatic lumbar scoliosis: long-term follow-up of a prospective, multicenter cohort of 160 patients
Authors: Sardi Juan Pablo , Lazaro Bruno , Smith Justin S. , Kelly Michael P. , Dial Brian , Hills Jeffrey , Yanik Elizabeth L. , Gupta Munish , Baldus Christine R. , Yen Chun Po , Lafage Virginie , Ames Christopher P. , Bess Shay , Schwab Frank , Shaffrey Christopher I. , Bridwell Keith H. 
Published: September 2022

OBJECTIVE
Previous reports of rod fracture (RF) in adult spinal deformity are limited by heterogeneous cohorts, low follow-up rates, and relatively short follow-up durations. Since the majority of RFs present > 2 years after surgery, true occurrence and revision rates remain unclear. The objectives of this study were to better understand the risk factors for RF and assess its occurrence and revision rates following primary thoracolumbar fusions to the sacrum/pelvis for adult symptomatic lumbar scoliosis (ASLS) in a prospective series with long-term follow-up.

METHODS
Patient records were obtained from the Adult Symptomatic Lumbar Scoliosis–1 (ASLS-1) database, an NIH-sponsored multicenter, prospective study. Inclusion criteria were as follows: patients aged 40–80 years undergoing primary surgeries for ASLS (Cobb angle ≥ 30° and Oswestry Disability Index ≥ 20 or Scoliosis Research Society-22r ≤ 4.0 in pain, function, and/or self-image) with instrumented fusion of ≥ 7 levels that included the sacrum/pelvis. Patients with and without RF were compared to assess risk factors for RF and revision surgery.

RESULTS
Inclusion criteria were met by 160 patients (median age 62 years, IQR 55.7–67.9 years). At a median follow-up of 5.1 years (IQR 3.8–6.6 years), there were 92 RFs in 62 patients (38.8%). The median time to RF was 3.0 years (IQR 1.9–4.54 years), and 73% occurred > 2 years following surgery. Based on Kaplan-Meier analyses, estimated RF rates at 2, 4, 5, and 8 years after surgery were 11%, 24%, 35%, and 49%, respectively. Baseline radiographic, clinical, and demographic characteristics were similar between patients with and without RF. In Cox regression models, greater postoperative pelvic tilt (HR 1.895, 95% CI 1.196–3.002, p = 0.0065) and greater estimated blood loss (HR 1.02, 95% CI 1.005–1.036, p = 0.0088) were associated with increased risk of RF. Thirty-eight patients (61% of all RFs) underwent revision surgery. Bilateral RF was predictive of revision surgery (HR 3.52, 95% CI 1.8–6.9, p = 0.0002), while patients with unilateral nondisplaced RFs were less likely to require revision (HR 0.39, 95% CI 0.18–0.84, p = 0.016).

CONCLUSIONS
This study provides what is to the authors’ knowledge the highest-quality data to date on RF rates following ASLS surgery. At a median follow-up of 5.1 years, 38.8% of patients had at least one RF. Estimated RF rates at 2, 4, 5, and 8 years after surgery were 11%, 24%, 35%, and 49%, respectively. Greater estimated blood loss and postoperative pelvic tilt were significant risk factors for RF. These findings emphasize the importance of long-term follow-up to realize the true prevalence and cumulative incidence of RF.
ТРЕНДИ DIGITAL-МАРКЕТИНГУ В УМОВАХ КРИЗИ
Authors: Martyniuk O. V. 
Published: September 2022

В статті визначено основні тренди digital-маркетингу в умовах кризи. Виявлено тенденції його подальшого розвитку з урахуванням особливостей сучасного етапу економічного розвитку, невід’ємною частиною якого є використання цифрових технологій. Сформовано цілі digital-маркетингу з метою комунікації та утримання уваги споживачів, залучення нових клієнтів, збільшення трафіку та отримання стабільного доходу. Доведено, що імплементація сучасних трендів digital-маркетинг є інструментом, здатним посилити позиції компанії на ринку, підвищити цінність пропозиції компанії споживачам, завоювати довіру цільової аудиторії, підвищити рейтинг бренду в пошуковій мережі.
МЕТОДИ ОЦІНКИ РІВНЯ ЕКОНОМІЧНОЇ БЕЗПЕКИ ПІДПРИЄМСТВА: ПІДХОДИ ДО ОЦІНЮВАННЯ ТА ЗАБЕЗПЕЧЕННЯ ЕКОНОМІЧНОЇ БЕЗПЕКИ
Authors: Shуlo Zh. S. , Krechko M. Yu. 
Published: September 2022

У статті досліджено та узагальнено підходи до оцінки рівня економічної безпеки підприємства. Проаналізовано зміст, переваги й недоліки кожного з них. Визначено, що сучасна економічна література не має єдиної методики комплексної оцінки економічної безпеки підприємства з урахуванням усіх необхідних для цього критеріїв. Запропоновано використання методичного підходу, що розроблений на основі узагальнення декількох підходів і складається з послідовних етапів оцінки для комплексного оцінювання рівня економічної безпеки підприємства.
POSSIBILITIES OF DIFFERENT APPROACHES USING DURING DENTAL RESTORATION IN PRESCHOOL CHILDREN
Authors: Soloshenko J.I. 
Published: September 2022

Caries of temporary teeth in children occurs already from the first year of life, and the prevalence and intensity of early childhood caries tend to increase with age. Therefore, its treatment in children of early childhood and preschool age is a difficult but very important task for a dentist. The purpose of our study was to compare different approaches to oral hygiene in children of early childhood and preschool age. We examined 25 children aged 2 to 6 years who had suband decompensated caries and belonged to 2 health groups. These children were divided into two groups depending on the approach to dental treatment. The first group consisted of 10 children who were treated in outpatient settings. The second group consisted of 15 children who underwent oral rehabilitation under general anesthesia. The children of the first group were 5-6 years old persons, the second group included 2-5 years old children. Treatment of children of the 1st group, who had a positive attitude to dental manipulations, was carried out under local anesthesia in an outpatient setting. In the 2nd group of children who had either a negative attitude to dental treatment or an early age, rehabilitation was carried out under general anesthesia. Isolation of the working field was carried out using a rubberdam system. Universal nano-ceramic material SeramX SphereTEC one (Dentsply) was used for permanent fillings. When diagnosing pulpitis, treatment was carried out by the method of vital amputation or extirpation. Bio MTA Plus (Cerkamed P.P.H, Poland) was used as biological material during amputation, and Metapex filling material (Meta Biomed) was used to fill root canals during extirpation. Riva LC (SDI Limited, Australia) was used as a gasket for pulpitis.
Research results and their discussion. We could not (in the most cases) provide quality treatment to the children of the 1st group, despite the fact that they had an older age, a lower intensity of caries, and a lower percentage of complicated caries. Although there is a significant number of dental visits (from 4 to 9) compared to children of the 2nd group, who were completely rehabilitated in the oral cavity in one visit.
Conclusions. As the results of the clinical study demonstrated, it is better to treat children in early childhood and preschool age who have a high intensity of caries under general anesthesia. This will allow the doctor to carry out the high-quality treatment according to modern protocols with a predictable result and will save the child from a negative experience of dental treatment, which in the future will make it possible to safely carry out rehabilitation of the oral cavity in an outpatient setting.
SISTEM INFORMASI PUSAT KARIR DAN TRACER STUDY PADA UNIVERSITAS BINA DARMA BERBASIS ANDROID
Authors: Riska Aprilliah  , Supratman Edi 
Published: September 2022

Kemajuan teknologi pada saat ini yang semakin berkembang sangat berperan penting dalam menunjang segala macam kegiatan terutama dalam pemanfaatan data dan pencarian informasi dalam berbagai bidang, seperti bidang pendidikan. Pusat karir adalah pusat sistem pendidikan dan pelatihan yang diperuntukkan bagi alumni suatu perguruan tinggi. Adapun tracer study merupakan sebuah layanan yang disediakan oleh setiap lembaga pendidikan untuk melacak alumni yang telah lulus dari lembaganya yang mana nantinya dapat digunakan untuk akreditasi dan pendataan para lulusan yang ada. Pada Universitas Bina Darma memiliki 22 Program Studi, dan memiliki lulusan sebanyak 1392 pada tahun 2019, 1100 alumni pada tahun 2020, dan 1063 alumni pada tahun 2021. Dengan banyaknya lulusan setiap tahunnya pada Universitas Bina Darma, maka tujuan dari penelitian ini adalah membangun dan menerapkan sistem informasi pusat karir dan tracer study pada Universitas Bina Darma. Setiap perguruan tinggi diharapkan bisa mempunyai sistem penelusuran alumni berupa tracer study dan pusat pengembangan karir untuk mengetahui penyerapan dan posisi lulusan dalam dunia kerja. Tujuan penelitian ini adalah untuk membangun sistem informasi pusat karir dan tracer study berbasis android agar dapat memudahkan tim tracer study dalam melacak data alumni. Metode yang digunakan dalam penelitian ini adalah Metode Prototype. Penelitian ini akan dilakukan di Universitas Bina Darma yang akan dilaksanakan pada bulan Februari sampai dengan Maret 2021. Hasil penelitian yang diharapkan dapat berupa aplikasi sistem pusat karir dan tracer study berbasis android.