bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolated Lateral Tibiofemoral Compartment Osteoarthritis
Authors: Plancher Kevin D. , Briggs Karen K. , Chinnakkannu Karthikeyan , Dotterweich Kathryn A. , Commaroto Sarah A. , Wang Karina H. , Petterson Stephanie C. 
Published: June 2022

Background:
Lateral unicompartmental knee arthroplasty (UKA) is an excellent option to alleviate disability and restore function in patients with lateral compartment knee osteoarthritis (OA). The purpose of the present study was to determine the survivorship and long-term outcomes in both younger/middle-aged and older patients with lateral compartment OA following non-robotically-assisted, fixed-bearing lateral UKA and to determine if an acceptable symptom state can be achieved.

Methods:
All patients were managed with fixed-bearing lateral UKA by a single surgeon utilizing a lateral parapatellar approach without robotic assistance. The primary outcome variables were the Knee injury and Osteoarthritis Outcome Score (KOOS) Activities of Daily Living (ADL) and Sport subscale scores. In addition, the other KOOS subscores, the Lysholm score, the achievement of the Patient Acceptable Symptom State (PASS), and the Veterans RAND (VR-12) Physical Component Summary score (PCS) and Mental Component Summary score (MCS) were collected. Failure was defined as conversion to total knee arthroplasty (TKA). Patients were divided into 2 cohorts: younger/middle-aged patients (<60 years of age) and older patients (≥60 years of age).

Results:
A cohort of 256 patients underwent medial (n = 193) or lateral (n = 63) UKA. Sixty-one patients met the inclusion criteria. At mean of 10 years (range, 4 to 17 years) of follow-up, there were no significant differences between the groups in terms of any patient-reported outcome measures (p > 0.05). The percentage of patients in whom PASS was achieved on the KOOS ADL and Sport subscores was 82% and 88%, respectively, in the younger cohort and 80% and 80%, respectively, in the older cohort. The mean survival estimate of the prothesis was 15.3 years (95% confidence interval [CI], 14.5 to 16.2 years) for the entire cohort. The estimated rate of implant survival in the younger cohort was 100% at 5 and 10 years, and the estimated rate of implant survival in the older cohort was 98% at 5 years and 96% at 10 years.

Conclusions:
Lateral fixed-bearing, non-robotic UKA for the treatment of isolated lateral compartment OA resulted in >80% of patients reaching an acceptable symptom state in terms of both activities of daily living and sporting activities. UKA provides an excellent option that provides longevity with high PASS rates and return to activities with a low risk of complications and failure.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Prediction of Elastic Properties of Thin Homogeneous Layers Based on Seismic Data
Authors: Alekseeva P.A. , Kerusov I.N. 
Published: June 2022

Abstract
—Many attributes and inversion transformations solving the problem of extracting information on the elastic properties of a medium are based on the Zoeppritz equation or its approximations calculated for a boundary between two half-spaces. In a real medium, a seismic signal is in interference as a result of reflection from the top and bottom of individual thin layers or units, the elastic properties of which differ from those of the adjacent rocks. In such media, there is a discrepancy between experimental and theoretical dependences of the reflection coefficient amplitude developed for half-spaces. For a homogeneous thin layer, the change in the frequency response of the reflection coefficient is associated with the reflection coefficients of the layer top and bottom interfaces and the wave traveltime within the layer at the same time. A detailed analysis of the reflection coefficient amplitude of a homogeneous thin layer using the spectral decomposition technology allows us to isolate only the change in the reflection coefficients, regardless of the thickness. The proposed method for predicting the elastic properties of thin beds is based on the analytical derivation of the reflection coefficient of a homogeneous thin bed, according to which there is a parabolic relation between the squared reflection coefficient amplitude and the squared frequency. The approximation coefficient at the zero degree of the argument mainly characterizes the properties of a medium, unlike the first- and second-degree coefficients, which depend both on the properties and on the thickness of the bed. Therefore, it makes sense to use the approximation coefficient at the zero degree of the argument as an attribute of the wavefield to predict the elastic properties of thin beds in the interwell space. A good example of a relatively homogeneous thin layer is a narrow riverbed. Determining the properties of the rock filling the channel feature helps identify more sandy areas that are promising for further development of the field.
RoughSet based Feature Selection for Prediction of Breast Cancer
Authors: BHUKYA HANUMANTHU , Manchala Sadanandam 
Published: June 2022

Abstract
Breast cancer is the most deadly cancer and has highest mortality rate in women all over the world. Early prediction of breast cancer can improve the survival rate of the patient. Consequently, high accuracy in cancer prediction is important to avoid any mis-diagnosis. Machine learning algorithms can contribute in early prediction and diagnosis of breast cancer. In this study, we have used rough set based feature selector to extract relevant features from the breast cancer feature set and classify them using machine learning algorithm like Decision Tree, Naive Bayes, Support Vector Machine, K-Nearest Neighbor, Logistic Regression, Random Forest, Adaboost. The main aim is to predict cancerous breast nodules, using rough set driven feature selection and machine learning classification algorithms. The results were evaluated pertaining to accuracy, sensitivity and specificity and positive predictive value. It is observed that random forest outperformed all other classifiers and achieved the highest accuracy using the proposed approach (95.23%).
Adaptive Data Aggregation Scheme with Optimal Hop Selection using Optimized Distributed Voronoi-based Cooperation with Energy-aware Dual-path Geographic Routing Protocol
Authors: Sri M. , Pankajavalli P.B. 
Published: June 2022

Abstract
In Wireless Sensor Network (WSN), the consumption of energy is high due to the data transmission in the sensing region. The Optimized Distributed Voronoi-based Collaboration (ODVOC) optimizes data delivery and it suffers from huge energy consumption. To overcome this drawback, a data aggregation scheme is introduced to expand the lifetime of the network and to minimize the energy utilization. Data aggregation is a significant approach that preserves the unwanted usage of energy during data transmission. In this paper, the Optimized Distributed Voronoi-based Cooperation scheme with Energy-aware Dual-path Geographic Routing (DAOHS-ODVOC-EDGR) is proposed which incorporates the polydisperse aggregation scheme and it aggregates the indispensable data in the intermediary nodes. The effective data aggregation is achieved by the estimation of the waiting time of the data at every intermediary node and cost function that is used for electing the next-hop node. In the proposed protocol, the buffer value of every node is divided to retain diversified kinds of flow for effective and fair delivery of data. The rate of transmission at the source and intermediary node is altered during the congestion. The proposed DAOHS- ODVOC-EDGR protocol is tested via simulation scheme. The result of the simulation exposes that DAOHS-ODVOC-EDGR outperforms the TESDA and DVOC protocol in terms of network lifetime, energy efficiency, and hop count delay.
Speech Enhancement, Databases, Features and Classifiers in Automatic Speech Recognition: A Review
Authors: Swamy Mahadeva 
Published: June 2022

Abstract

This paper gives a comprehensive introduction about speech production and perception in Human beings, discusses the challenges and applications, frame work of Automatic Speech Recognition(ASR) systems, and provides the detailed description about the architecture of ASR. The paper highlights the problem definition, general objectives, scope of ASR research. The work provides meticulous review about the baseline ASR systems and indicates the need for research in ASR. A methodical way of designing a speech corpus for Indian languages is presented in this paper. Finally wavelet based Thresholding techniques are utilized to process the designed speech corpus. The experiments are carried out on the Kannada speech corpus consisting of continuous sentences and results are compared with those obtained on the bench marking TIMIT dataset. The results convey that the Proposed method performs better for both the databases for various SNR conditions.
Incidence, Risk Factors, Prevention and Treatment of Postmastectomy Pain Syndrome in Breast Cancer: a Multicenter Study
Authors: Ren Yinpeng , Kong Xiangyi , Yang Qinheng , Ouyang Liquan , Liu Qiang , Dong Hao , Wang Zhongzhao , Fang Yi , Wang Jing 
Published: June 2022

Abstract
Postmastectomy pain syndrome (PMPS) is a common postoperative condition after breast cancer surgery, The aim of this study was to investigate the incidence rate and risk factors of PMPS, and to propose prevention and treatment methods. The study included 1790 postoperative breast cancer patients from three hospitals from 2017 to 2021, of which 302 (13.0%) patients with PMPS were included in the study. Age, breast surgery type, axillary surgery type and radiotherapy are the risk factors of PMPS. Age, radiotherapy and chemotherapy affect the pain degree of PMPS during movement. For breast cancer patients with high risk factors, pain should be actively prevented during perioperative period. Oral pharmacological agents, multidisciplinary combination therapy, local anesthetics and regional anesthesia are the most common treatment of PMPS.
Pyrite residues mixed leaching characteristics from an abandoned sulfuric acid production plant in Santa Catarina, Brazil
Authors: Gonçalves Janaína Oliveira , Oliveira Luis Felipe Silva , Dotto Guilherme Luiz , Oliveira Marcos Leandro Silva 
Published: June 2022

Abstract
Coal mining is a major source anthropogenic of sulfur oxides in the world and an important contributor to acid rain. In this process are produced high concentrations of potentially hazardous elements, that when exposed to weathering leached and flowed directly into the sea. Therefore, this work aims to verify the detailed leachate composition of rejects and ash coal from an abandoned sulphuric acid production plant. Leachate concentrations were determined using inductively coupled plasma atomic emission spectrometry, Inductively coupled plasma mass spectrometry, and high-performance liquid chromatography. The chemical characterization indicated highly toxic contaminants exposed to opencast, which favor bioaccumulation and the formation of secondary materials. Therefore, the work emphasizes the importance of listing these leachates due to the harm they cause to living beings and the ecosystem's disorder, thus corroborating for there to be more attention and correct destination for these tailings.
ZNF185 prevents stress fiber formation through the inhibition of RhoA in endothelial cells
Authors: Suzuki Soichiro , Ando Fumiaki , Kitagawa Sae , Hara Yu , Fujiki Tamami , Mandai Shintaro , Susa Koichiro , Mori Takayasu , Sohara Eisei , Rai Tatemitsu , Uchida Shinichi 
Published: June 2022

Abstract
Signaling through cAMP/protein kinase A (PKA) promotes endothelial barrier function to prevent plasma leakage induced by inflammatory mediators. The discovery of novel PKA substrates in endothelial cells has increased our understanding of the molecular mechanisms involved in vessel maturation. In this study, we evaluated a cAMP inducer, forskolin, and a phospho-PKA substrate antibody to identify ZNF185 as a PKA substrate. ZNF185 interacted with PKA and a deletion mutant of ZNF185, which lacks the PKA-interacting domain, was not phosphorylated by PKA. In addition to PKA, ZNF185 colocalized with F-actin in endothelial cells. Both phospho-ZNF185 and F-actin accumulated in the plasma membrane region in response to forskolin to stabilize the cortical actin structure. By contrast, ZNF185 knockdown disrupted actin filaments and promoted stress fiber formation without inflammatory mediators. Constitutive activation of RhoA was induced by ZNF185 knockdown, which resulted in forskolin-resistant endothelial barrier dysfunction. ZNF185 was essential for cAMP/PKA/RhoA signaling for the suppression of endothelial hyperpermeability. Thrombin protease was used as a positive control to assemble stress fibers via RhoA activation. Unexpectedly, ZNF185 was cleaved by thrombin, resulting in an N-terminal actin-targeting domain and a C-terminal PKA-interacting domain. Irreversible dysfunction of ZNF185 protein potentially causes RhoA-dependent stress fiber formation by thrombin.
Bacteroidales-specific antimicrobial gene analysis identifies gastrointestinal tract reservoirs of microbial sub strains selected for fecal dominance
Authors: Morrow Casey , Koo Hyunmin 
Published: June 2022

Abstract
To gain insight into the dynamics of selection for the dominant fecal microbe strain from the gut ecosystem, we analyzed individual fecal samples from 3 longitudinal metagenomic DNA sequencing data sets for genes encoding Bacteroidales-specific antimicrobial proteins (BSAP) that have functions to restrict species specific replication of Bacteroides uniformis (BSAP-2) or Bacteroides vulgatus (BSAP-3). Individuals had B. vulgatus or B. uniformis sub strains with either complete or deleted BSAP gene patterns that did not change over time, indicating an origin from a stable sub strain reservoir. In most individuals, the BSAP phenotype and gene pattern recovered after single or multiple antibiotics was the same as the pre antibiotic strain. In some individuals, strain change following antibiotics correlated with the presence of the BSAP positive phenotype. Our studies demonstrate the dominant fecal Bacteroides strain contains a defined BSAP phenotype that can influence the selection from the gut ecosystem sub strain reservoir.
Targeting Hypertension in a Low-Income, Uninsured Population Through a Self-Management Program
Authors: Stock Eleanor Louise 
Published: June 2022

Abstract
PurposeSelf-management is a crucial skill for optimal management of chronic health conditions such as hypertension. Low-income and uninsured individuals are especially vulnerable to the risks and complications associated with hypertension. Self-management programs have demonstrated positive results for management of chronic health conditions. This volunteer clinic for the medically underserved in Central Florida does not have an established protocol for hypertension management. Therefore, the purpose of this project was to pilot a hypertension self-management program with the primary goal of improving blood pressure.Project DesignThis was a pilot project to determine the effectiveness of a hypertension self-management program in a low-income, uninsured population.MethodSeven eligible participants participated in a 12-week hypertension self-management program. The self-management program consisted of individual sessions focused on education, self-monitoring, and support. The program included three face-to-face appointments and two follow-up phone calls.ResultsOn average participants’ systolic blood pressures decreased by 9.14 mmHg, and diastolic blood pressures decreased by 6.14 mmHg. Self-management assessment scores increased in every participant, and 86% of participants had a reduction in weight and body mass index. Attendance at scheduled appointments was 100%, and home blood pressure log completeness was 75.98% for twice a day monitoring, 84.18% for once-a day monitoring.ConclusionThis hypertension self-management program demonstrated positive outcomes in a short period of time. It is a low-cost and feasible option for this volunteer medical clinic for the medically underserved.
Suprachoroidal Triamcinolone Acetonide for the treatment of Macular Edema Associated with Retinal Vein Occlusion: A Pilot Study
Authors: Ali Boushra , Alhalabi Nawras , Azmeh Arwa 
Published: June 2022

Abstract
Background: Intravitreal administration of therapeutic agents for the management of Retinal vein occlusion (RVO) associated Macular Edema (ME) is still hindered by adverse events. Delivery of therapeutics into the Suprachoroidal space provides a novel promising approach. we aim to study of the efficacy and safety of suprachoroidal injection of Triamcinolone Acetonide (TA) using a microinjector as a mono treatment of ME due to RVO.Methods: This trial included 16 eyes of 16 patients with RVO associated ME presenting to the department of ophthalmology, Almouwasat university hospital, Syria. 4 mg of preserved TA was injected suprachoroidally 4 mm away from the inferotemporal limbus using a patient-customized microinjector. After injection, patients were followed after 1 week then monthly for 3 months.Primary outcome measures included the percentage of participants with best-corrected visual acuity (BCVA) gain≥ 15 letters and increased intraocular pressure (IOP)≥ 20 mmHg in months 1,2, and 3, secondary measures included mean change from baseline BCVA, central subfield thickness (CST), and IOP through each of the follow-up points in addition to other measures.Results: After injection, BCVA gain≥15 letters occurred in 68.7%, 62.5%, 50%, 50% of patients at week 1 and through months 1,2 and 3 respectively, the mean BCVA improved significantly by 16.4, 16, 14.4, and 11.9 letters (p-value<0.0005) at week 1 and months 1,2 and 3 respectively. This visual gain was associated with significant reduction of CST by 290.94±181.76 (week-1) (p-value<0.0005), 274.31±184.60 (month-1) (p-value<0.0005), 183.50±165.61 (month-2) (p-value=0.006) and 137,75±156.25 microns (month-3) (p-value=0.038). We reported one case of increased IOP ≥ 20 mmHg in the first month that decreased in the second month. The mean change of IOP readings was not statistically significant, with an increase ranging from 0.75 mmHg after the first week (p-value=0.09) and 0.5 mmHg after 3 months (p-value=0.72).Conclusion: This study suggests that suprachoroidal TA could be well tolerated and efficacious as a mono-treatment of RVO associated ME. Future clinical trials are required to confirm its longer-term safety and efficacy and to compare this efficacy with the other therapeutic options.Trial registration: This study was retrospectively registered at clinicaltrials.gov (ID: NCT05038072) on September 8, 2021.
Correlations between heavy metals and chronic diarrhea and constipation in US adults
Authors: Xie Minhua , Lei Xia 
Published: June 2022

Abstract
Background
Heavy metals such as lead, mercury, and cadmium are closely related to human health. However, their correlations with chronic constipation and diarrhea have not been systematically studied.
Aims
To evaluate the associations between the blood levels of lead, cadmium, and mercury with chronic constipation and diarrhea.
Methods
First, we collected and analyzed the National Health and Nutrition Examination Survey (NHANES) (2009–2010) dataset from the USA. Then, we evaluated the associations between heavy metals and chronic diarrhea and constipation using the survey generalized linear model (SVYGLM), and the weighted quantile sum (WQS) regression. Finally, we used restricted cubic splines (RCS) models to determine the dose-response relationship between heavy metals and the prevalence of chronic diarrhea and constipation.
Results
The blood levels of cadmium were positively correlated with chronic diarrhea [p = 0.002, odds ratio (OR) = 1.33, 95% confidence interval (CI): 1.14–1.54] and the blood levels of lead were negatively correlated with chronic constipation (p = 0.01, OR = 0.84, 95% CI: 0.75–0.95) by the SVYGLM. Based on the WQS regression, the blood levels of cadmium were positively correlated with chronic diarrhea (p = 0.008, OR = 1.21, 95% CI: 1.05–1.39), the blood levels of lead were negatively correlated with chronic constipation (p = 0.016, OR = 0.91, 95% CI: 0.85–0.98), and the levels of mercury were negatively correlated with chronic constipation (p = 0.008, OR = 0.93, 95% CI: 0.89–0.98). Morever, a linear dose-response association was detected between the blood concentration of cadmium and the prevalence of chronic diarrhea (nonlinearity p = 0.51). Additionally, a non-linear dose-response association was detected between blood concentration of lead and the prevalence of chronic constipation (nonlinearity p = 0.002).
Conclusion
The blood levels of cadmium were positively associated with chronic diarrhea, and the blood levels of lead and mercury were inversely associated with chronic constipation.
Implementation and Design of Secure Business Process Models Based on Organisational Goals
Authors: Patrick Adeel 
Published: June 2022

Abstract
Business processes are essential instruments used for the coordination of organisational activities in order to produce value in the form of products and services. Information security is an important non-functional characteristic of business processes due to the involvement of sensitive data exchanged between their participants. Therefore, potential security shortfalls can severely impact organisational reputation, customer trust and cause compliance issues. Nevertheless, despite its importance, security is often considered as a technical concern and treated as an afterthought during the design of information systems and the business processes which they support. The consideration of security during the early design stages of information systems is highly beneficial. Goal-oriented security requirements engineering ap- proaches can contribute to the early elicitation of system requirements at a high level of abstraction and capture the organisational context and rationale behind design choices. Aligning such requirements with process activities at the operational level augments the traceability between system models of different abstraction levels and leads to more robust and context-aware operationalisations of security. Therefore, there needs to be a well-defined and verifiable interconnection between a system’s security requirements and its business process models. This work introduces a framework for the design of secure business process models. It uses security-oriented goal models as its starting point to capture a socio-technical view of the system to-be and its security requirements during its early design stages. Concept mappings and model transformation rules are also introduced as a structured way of extracting business process skeletons from such goal models, in order to facilitate the alignment between the two different levels of abstraction. The extracted business process skeletons, are refined to complete business process models through the use of a set of security patterns, which standardise proven solutions to recurring security problems. Finally, the framework also offers security verification capabilities of the produced process models through the introduction of security-related attributes and model checking algorithms. Evaluation of this work is performed: (i) through individual evaluation of its components via their application in real-life systems, (ii) a workshop-based modelling exercise where participants used and evaluated parts of the framework and (iii) a case study from the public administration domain where the overall framework was applied in cooperation with stakeholders of the studied system. The evaluation indicated that the developed framework provides a structured approach which supports stakeholders in designing and evaluating secure business process models.