bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative prevention of thrombohemorrhagic complications in patients with calculous cholecystitis and obstructive jaundice
Authors: Fedorov V. E. , Kharitonov B. S. , Aslanov A. D. , Logvina O. E. 
Published: May 2022

The OBJECTIVE was to improve the effectiveness of prevention of thrombohemorrhagic disorders in patients with calculous cholecystitis and obstructive jaundice.METHODS AND MATERIALS. The clinic examined 537 patients operated on for obstructive jaundice. From 2010 to 2015, the prevention of thrombohemorrhagic complications consisted in the determination of risk factors, elastic compression of the lower extremities and the appointment of anticoagulants (1st comparative group). Since 2015, all medical measures have also been carried out taking into account the stages of obstructive jaundice (2nd study group).RESULTS. When comparing the results, the number of subhepatic abscessed hematomas decreased from 4 (1.6 %) patients in the first group to 2 (0.8 %) in the second, the number of gastric bleedings-from 6 (2.4 %) to 3 (1.2 %), metrorrhagia – from 3 (1.2 %) to 1 (0.4 %), pancreatic necrosis – from 8 (3.2 %) to 5 (1.9 %), pulmonary embolism – from 7 (2.8 %) to 5 (2.0 %), the number of strokes and transient disorders of cerebral circulation – from 5 (2.0 %) to 3 (1.2 %), the number of cardiac arrhythmias in the form of atrial fibrillation-from 3 (1.2 %) to 2 (0.8 %). The incidence of myocardial infarction decreased from 5 (2.0 %) patients to 3 (1.2 %), and the incidence of mesenteric vascular thrombosis decreased from 3 (1.2 %) to 1 (0.4 %). In group 1, 2 (0.8 %) patients had hemobilia.CONCLUSION. In addition to protocols and standards, the prevention of thrombohemorrhagic complications should take into account the stages of obstructive jaundice. During the period of cholestasis, the prevention of thrombohemorrhagic complications should be used in the same volume as in the absence of jaundice. In hepatocytolysis, it should be performed using the CHA2DS2-VASc scale with the HEMORR2HAGESscale as a safety net. In cholangitis, on the contrary, the main role is assigned to the HEMORR2HAGESscale.
Molecular-genetic substantiation of combined therapy in the early postoperative period in diffuse peritonitis
Authors: Vlasov A. P. , Al-Kubaisi Sh. S. , Vlasova T. I. , Salakhov Y. K. , Myshkina N. A. , Romanov D. A. , Ali-Fuad F. A. , Al-Anbari S. T. 
Published: May 2022

The OBJECTIVE was to give a molecular genetic foundation of combination therapy in the early postoperative period for peritonitis.METHODS AND MATERIALS. 70 patients with diffuse peritonitis were studied: the first (n=35) – patients underwent basic treatment, the second (n=35) – combined treatment with the inclusion of Remaxol and laser irradiation. The severity of endotoxemia and oxidative stress, the state of the hemostasis system and the functional status of the liver were determined. Molecular genotyping of the following genes was performed: beta subunits of platelet fibrinogen receptor (T1565C, ITGB3), fibrinogen (G(-455)A, FGB), catalase (-262C/T, CAT), superoxide dismutase (C47T, SOD2).RESULTS. It was found that the early postoperative period in patients with peritonitis is accompanied by endotoxemia, oxidative stress, impaired functional status of the liver, hypercoagulation and hypofibrinolysis. In patients with conditionally «mutant» genotypes of the studied genes, peritonitis is more severe, the severity of changes in the studied indicators of homeostasis is greater. At the same time, the effectiveness of therapy decreased, the number of complications increased, and the stay of patients in the hospital increased. The early inclusion of Remaxol and laser radiation in basic therapy increases the overall effectiveness of treatment: the severity of endotoxemia and oxidative stress decreases, the functional state of the liver and hemostasis system is restored relatively quickly, and as a result, an improvement in clinical results has been registered (a 37.5 % decrease in the frequency of complications (χ2=3.360, p=0.047) and a reduction in the length of stay of patients in the hospital by 16.6 % (p<0.05)).CONCLUSION. The inclusion of Remaxol and laser therapy in the early postoperative period in the treatment regimen of patients with peritonitis makes it possible to influence pathogenetically important links of the disease relatively quickly, which improves treatment results. This type of therapy is particularly effective in patients with polymorphic genotypes T1565C and C1565C of the ITGB3 gene.
Peculiarities of nasogastric and nasojejunal feeding during the early period of acute severe pancreatitis
Authors: Sivkov O. G. , Sivkov A. O. , Popov I. B. , Zaitsev E. U. 
Published: May 2022

The OBJECTIVE of the study was to identify factors independently influencing intolerance to early enteral feeding via a nasogastric and nasojejunal tube in patients during the early phase of severe acute pancreatitis.METHODS AND MATERIALS. An open, randomized, controlled, cohort study was carried out. Out of 64 patients with predictors of severe acute pancreatitis, a cohort with severe form was isolated, in which 16 patients received nasogastric and 15 patients – nasojejunal feeding. The enteral feeding intolerance criteria were: discharge via the nasogastric tube >500ml at a time or >500ml/day compared to total enteral feeding administered during 24 hours, intensified pain syndrome, abdominal distension, diarrhea, nausea and vomiting. Indicators featuring prognostic significance were identified using the logistic regression technique. The null hypothesis was rejected at p<0.05.RESULTS. The presented findings demonstrate that a more severe multiple organ failure (SOFA – OR – 1.283, 95 % CI 1.029–1.6, p=0.027), the operative day (OR – 4.177, 95 % CI 1.542–11.313, p=0.005) increase while the nasojejunal route of nutrients delivery decreases (OR – 0.193, 95 % CI 0.08–0.4591, p≤0.001) the incidence of large residual stomach volumes. Postpyloric feeding reduces the risk of developing pain syndrome (OR – 0.191, 95 % CI 0.088–0.413, p≤0.001), abdominal distension (OR – 0.420, 95 % CI 0.203–0.870, p=0.002), nausea and vomiting (OR – 0.160, 95 % CI 0.069–0.375, p≤0.001).CONCLUSION. During severe acute pancreatitis, multiple organ dysfunction, the nasogastric route of enteral feeding delivery, and the fact of a surgery increase independently the risk of developing large residual stomach volumes. In case of severe acute pancreatitis, the nasogastric route of nutrients administration increases the development of such manifestations of enteral feeding intolerance as nausea, vomiting, pain intensification, and abdominal distension. In patients with severe acute pancreatitis, the nasoejunal route of administration of nutrients is preferable.
Pengaruh Harga, Promosi, dan Brand Ambassador yang Dimediasi oleh Citra Merek terhadap Keputusan Pembelian pada Situs Belanja Online Shopee
Authors: Fauziah Ibnaty , Tunjungsari Hetty Karunia 
Published: May 2022

The purpose of this study was to determine whether prices, promotions, and brand ambassadors mediated by brand image influence purchasing decisions on the Shopee online shopping site. Determination of the sample using probability. The research data use secondary data, with questionnaire distribution techniques. The data collected were 200 respondents and processed using Partial Least Square (SmartPLS 3.0). This research was tested using a validity test, reliability test, R-square, and hypothesis testing. Tujuan dari penelitian ini adalah untuk mengetahui apakah harga, promosi, dan brand ambassador yang dimediasi citra merek memiliki pengaruh terhadap keputusan pembelian pada situs belanja online Shopee. Penentuan sampel menggunakan probability sampling. Data penelitian menggunakan data sekunder, dengan teknik penyebaran kuesioner. Data yang terkumpul sebanyak 200 data responden dan diolah menggunakan Partial Least Square (Smart PLS 3.0). Penelitian ini diuji menggunakan uji validitas, uji reliabilitas, R-square, dan uji hipotesis.
Pengaruh Brand Image, Brand Trust, dan Brand Communication terhadap Brand Loyalty Client Jasa Inspeksi Batu Bara PT Tribhakti Inspektama di Indonesia
Authors: Tanady Edi Sucipto , Firdausy Carunia Mulya 
Published: May 2022

The objective of this study is to examine the influences of brand image, brand trust, and brand communication on the brand loyalty of PT Tribhakti Inspektama clients in Indonesia. The number of respondents sampled was 115 respondents. These respondents were sampled by using the nonprobability sampling technique. The instruments to collect the data were collected by using an online questionnaire. The Method to analyze the data was by using multiple regression analysis. The results showed that brand image, brand trust, and brand communication have positive and significant influences on the brand loyalty of the clients of PT Tribhakti Inspektama. Therefore, PT Tribhakti Inspektama needs to give particular attention to brand image, brand trust, and brand communication to create brand loyalty for the clients. This is important to improve the company’s strength to get repeat orders and reduce the company’s burden to find new clients. Penelitian ini bertujuan untuk menguji pengaruh citra merek, kepercayaan merek, dan komunikasi merek terhadap loyalitas merek client PT Tribhakti Inspektama di Indonesia. Jumlah responden yang dijadikan sampel adalah 115 responden. Responden ini diambil sampelnya dengan menggunakan teknik nonprobability sampling. Instrumen untuk mengumpulkan data dikumpulkan dengan menggunakan kuesioner online. Metode analisis data menggunakan analisis regresi berganda. Hasil penelitian menunjukkan bahwa citra merek, kepercayaan merek, dan komunikasi merek berpengaruh positif dan signifikan terhadap loyalitas merek client PT Tribhakti Inspektama. Oleh karena itu, PT Tribhakti Inspektama perlu memberikan perhatian khusus pada citra merek, kepercayaan merek, dan komunikasi merek untuk menciptakan loyalitas merek dari client. Hal ini penting untuk meningkatkan kekuatan perusahaan untuk mendapatkan repeat order dan mengurangi beban perusahaan untuk mencari client baru.
Pengaruh Brand Awareness dan Brand Association terhadap Purchase Intention melalui Perceived Quality pada Laneige di Jakarta
Authors: Wijaya Jesica , Erdiansyah Rezi 
Published: May 2022

The purpose of this study was to examine the effect of the relationship between Brand Awareness and Brand Association towards Purchase Intention through the Perceived Quality of Laneige in Jakarta. The problem that exists in this research is the rare skincare research, while many sources said that the sales of beauty products are increasing growth every year. This research uses causal dan descriptive methods. For collecting the sample and data, purposive sampling was used and successfully gathered 124 respondents. Structural Equation Modeling (SEM) and PLS were used to process the data and descriptive statistics were obtained using IBM SPSS. The results obtained from the research using SmartPLS 3.0 tools are exogenous variables give a positive influence on endogenous variables of research that is the influence of Brand Awareness and Brand Association towards Purchase Intention through Perceived Quality of Laneige in Jakarta. The ultimate goal of this research is so that companies can know the factors that must be upgraded from the Beauty Brand especially Laneige to be able to reach more consumers in Indonesia. Tujuan dari penelitian ini untuk melihat pengaruh Brand Awareness dan Brand Association terhadap Purchase Intention melalui Perceived Quality pada perusahaan kosmetik korea yaitu Laneige di Jakarta. Alasan utama penelitian ini dilakukan adalah dikarenakan penelitian tentang skincare dan kosmetik yang belum banyak diteliti serta menurut beberapa sumber, penjualan produk kecantikan meningkat setiap tahunnya. Penelitian ini menggunakan metode deskriptif dan kausal. Dalam mengumpulkan data dan sampel, menggunakan purposive sampling dan berhasil mengumpulkan 124 responden melalui kuesioner yang dibagikan secara online melalui Google Form. Penelitian ini menggunakan Structural Equation Modeling (SEM) dan PLS untuk memproses data, serta menggunakan IBM SPSS untuk mengumpulkan statistik deskriptif. Hasil akhir yang didapat melalui penelitian ini adalah terdapat pengaruh positif dari variabel endogen yang dipengaruhi oleh Brand Awareness dan Brand Association terhadap Purchase Intention melalui Perceived Quality pada Laneige di Jakarta. Tujuan utama penelitian ini adalah agar perusahaan dapat mengetahui faktor yang harus ditingkatkan dari merek produk kecantikan agar dapat menjangkau konsumen yang lebih banyak di Indonesia.
Pengaruh Struktur Modal, Profitabilitas, dan Ukuran Perusahaan terhadap Nilai Perusahaan pada Perusahaan Pertambangan Batu Bara yang Terdaftar di Bursa Efek Indonesia Tahun 2016-2019
Authors: Efriyanti Efriyanti , Widjaja Indra 
Published: May 2022

The purpose of this research is to prove whether individually or simultaneously the independent variables (capital structure measured by Debt to Equity Ratio (DER), profitability measured by Return of Equity (ROE), and company value measured by Size) will have an impact on the dependent variable (company value). Through purposive sampling, 13 companies were found to have met the research criteria for a 4-year observation period from 2016 to 2019, and 52 observational data were obtained. Downloaded from the Indonesia Stock Exchange to obtain secondary data such as financial statements for all samples of companies. The data obtained were then calculated based on the formula for each variable and then reprocessed using the multiple linear regression test method along with the classical assumption test and at the end of the stage, the hypothesis was tested. The results of this research indicated that individually capital structure has a significant impact on company value with a significance value of 0.035, profitability also has a significant impact on company value with a significance value of 0.001, and company size is known to have no significant impact on company value with a significance value of 0.180 and simultaneously capital structure, profitability, and company size have a significant impact on company value with a significance value of 0.001. Tujuan dari penelitian ini untuk membuktikan apakah secara individual maupun secara simultan variabel independen (struktur modal yang diukur dengan Debt to Equity Ratio (DER), profitabilitas yang diukur dengan Return of Equity (ROE) dan ukuran perusahaan yang diukur dengan Size) akan berdampak terhadap variabel dependen (nilai perusahaan). Melalui purposive sampling didapatkan sampel penelitian sebanyak 13 perusahaan yang dianggap telah memenuhi kriteria penelitan untuk periode 4 tahun observasi dari tahun 2016 sampai dengan tahun 2019 dan diperoleh data pengamatan sejumlah 52 data. Dilakukan pengunduhan dari Bursa Efek Indonesia untuk memperoleh data sekunder berupa laporan keuangan untuk semua perusahaan sampel. Data yang diperoleh kemudian dilakukan perhitungan berdasarkan formula untuk masing-masing variabel kemudian diolah kembali dengan metode uji regresi linier berganda beserta uji asumsi klasik dan pada akhir tahapan dilakukan uji hipotesis. Hasil dari penelitian ini memperlihatkan secara individual struktur modal berdampak signifikan terhadap nilai perusahaan dengan nilai signifikansi sebesar 0,035, profitabilitas juga berdampak signifikan terhadap nilai perusahaan dengan nilai signifikansi sebesar 0,001, ukuran perusahaan diketahui tidak berdampak signifikan terhadap nilai perusahaan dengan nilai signifikansi sebesar 0,180 dan secara simultan struktur modal, profitabilitas dan ukuran perusahaan berdampak signifikan terhadap nilai perusahaan dengan nilai signifikansi sebesar 0,001.
Pengaruh Capital Adequacy Ratio (CAR), Loan To Deposit Ratio (LDR), dan Non-Performing Loan (NPL) terhadap Profitabilitas Perusahaan Perbankan yang Terdaftar di Bursa Efek Indonesia (BEI) Periode Tahun 2017-2019
Authors: Putri Novianti S. , Widjaja Indra 
Published: May 2022

A bank is one of the intermediary institutions or intermediaries from parties who have excess funds to parties who need funds. Therefore, the bank is one of the sectors that has a very important role in the stability and growth of the economy as a whole. To assess the performance of banking companies can be measured using ratios including Capital Adequacy Ratio (CAR), Loan to Deposit Ratio (LDR), and Non-Performing Loan (NPL). The purpose of this research is to know and analyze the impact of CAR, LDR, and NPL, partially and simultaneously on profitability at all banking companies (conventional and sharia) that are listed on the Indonesian Stock Exchange from the period 2017 to 2019. The research was conducted using samples from 41 banking companies. The samples were determined by the purposive sampling method. The results showed: 1) simultaneously tested that CAR, LDR, and NPL have a significant effect on profitability; 2) partially LDR and NPL have a significant effect on profitability, while CAR has no significant effect on profitability. Bank merupakan salah satu lembaga intermediasi atau perantara dari pihak yang memiliki kelebihan dana dengan pihak yang membutuhkan dana. Oleh karena itu, bank merupakan salah satu sektor yang memiliki peran yang sangat penting untuk stabilitas dan pertumbuhan perekonomian secara keseluruhan. Untuk menilai kinerja perusahaan perbankan, dapat diukur dengan menggunakan rasio diantaranya Capital Adequacy Ratio (CAR), Loan to Deposit Ratio (LDR), dan Non-Performing Loan (NPL). Tujuan penelitian ini ialah untuk mengetahui dan menganalisis pengaruh CAR, LDR, dan NPL, secara parsial dan simultan terhadap profitabilitas pada semua perusahaan perbankan (konvensional dan syariah) yang tercatat di Bursa Efek Indonesia periode 2017-2019. Penelitian ini dilakukan dengan menggunakan 41 sampel perusahaan perbankan. Teknik pengambilan sampel dengan menggunakan metode purposive sampling. Hasil penelitian menunjukkan: 1) secara simultan diuji bahwa CAR, LDR, dan NPL berpengaruh signifikan terhadap profitabilitas; 2) diuji secara parsial bahwa LDR dan NPL berpengaruh signifikan terhadap profitabilitas, sedangkan CAR tidak berpengaruh signifikan terhadap profitabilitas.
Laporan Kasus: Terapi Covid-19 pada Pasien dengan Komorbid Hipertensi
Authors: Laily Putri Dina Mahera 
Published: May 2022

Corona Virus Desease 2019 (COVID-19), is a disease caused by corona virus. According to the World Health Organization (WHO), COVID-19 is a tragedy in the world of global health. The main clinical manifestations are cough, fever, shortness of breath and in some cases can cause multiple organ failure, septic shock and metabolic acidosis which is difficult to correct. Where people who are elderly and have chronic disease generally have a poor prognosis. Prompt and appropriate therapy is expected to save patients. Until now, scientific evidence regarding the effectiveness and safety of these therapies is still very little. This study aims to evaluate the effectiveness and safety of COVID-19 therapy in COVID-19 patients with comorbid hypertension. The therapy used in this patient was azithromicin, ceftriaxone, levofloxacin and meropenem; Antiviral therapy was given hydroxychloroquine; symptomatic therapy for fever was given paracetamol; hypertension therapy was given amlodipine; Support therapy was given salbutamol and dexamethasone; Additional therapy was given vitamin C 1000 mg / 24 hours, and zinc. There was no worsening effect on the patient after receiving this therapy. Patients get treatment at RSUP Dr. Sardjito then was discharged after treatment without any complaints and with PCR swabs were negative results.
Keywords: Therapy, COVID-19, Comorbid, Hypertensi
Profil Penyakit Periodontal Pada Penderita Diabetes Melitus Berdasarkan Tipe Diabetes Melitus, Jenis Kelamin, dan Usia di RSUD dr. Kanujoso Djatiwibowo Pada Tahun 2016-2020
Authors: Aliyah Aanisah Nida , Listyawati Listyawati , Utami Nuryanni Dihin 
Published: May 2022

Penyakit periodontal adalah suatu keadaan peradangan dan degenerasi dari jaringan lunak maupun tulang penyangga gigi. Etiologi utama penyakit periodontal adalah faktor lokal yakni kondisi rongga mulut yang meningkatkan kerentanan seseorang terhadap infeksi periodontal atau yang dapat merusak jaringan periodontal dan dapat diperparah dengan adanya faktor sistemik diantaranya penyakit diabetes melitus. Tujuan penelitian ini adalah untuk mengetahui profil penyakit periodontal yang disertai diabetes melitus berdasarkan jenis penyakit periodontal, tipe diabetes melitus, jenis kelamin, dan usia di IRJA Publik Poliklinik Gigi dan Mulut RSUD dr. Kanujoso Djatiwibowo pada tahun 2016-2020. Penelitian ini merupakan deskriptif dengan sumber data sekunder berupa rekam medis pasien penyakit periodontal yang disertai diabetes melitus di IRJA Publik Poliklinik Gigi dan Mulut RSUD dr. Kanujoso Djatiwibowo pada tahun 2016-2020. Hasil penelitian didapatkan distribusi frekuensi pasien penyakit periodontal yang disertai diabetes melitus sebanyak 1 kasus. Jenis kelamin yang lebih dominan yakni perempuan sebanyak 3 pasien dan laki-laki sebanyak 1 pasien dengan jenis penyakit periodontal chronic periodontitis dengan DM tipe unspecified diabetes mellitus without complication. Pasien berjenis kelamin laki-laki dengan usia 63 tahun.
Neurotoxic Peptides in the Multicomponent Venom of the Spider Cupiennius Salei Part I. Primary Structure of Neurotoxic Peptides in Relation to their Biological Function
Authors: Schaller Johann , Kuhn-Nentwig Lucia , Schürch Stefan , Kämpfer Urs , Mülier Jürg , Nentwig Wolfgang 
Published: May 2022

Beside other components, spider venom contains neurotoxically acting peptides which predominantly target a variety of different ion channels within the spider's prey. From the multicomponent venom of Cupiennius salei 13 toxic peptides (CSTX-1 – CSTX-13) were purified by a combination of gel filtration, cation-exchange chromatography, and reverse-phase HPLC. The amino acid sequence of two important neurotoxic peptides, CSTX-1 (74 residues, 8352.6 Da) and CSTX-9 (68 residues, 7530.9 Da), as well as CSTX-2a (61 residues, 6865.7 Da), a truncated form of CSTX-1, were determined by Edman degradation. Sequence comparison of CSTX-1 with CSTX-9 revealed an identity of 53% as well as identical positions of all eight cysteine residues. CSTX-1 and CSTX-9 share the same disulphide bridge pattern linking Cys1–Cys4, Cys2–Cys5, Cys3–Cys8 and Cys6–Cys7. This disulphide bridge pattern is also found in other spider toxins such as agatoxins and curtatoxins. CSTX-1 and CSTX-9 belong to the family of the ion channel toxins containing the inhibitor cystine knot structural motif with the consensus sequence: CX3-7CX3-10CX0-7CX1-8CX4-20C. CSTX-2a and CSTX-9, lacking the lysine-rich C-terminal tail of CSTX-1, exhibit a much lower toxicity for Drosophila melanogaster than CSTX-1, providing good evidence for the direct involvement of this lysine-rich C-terminal tail in the toxicity of CSTX-1.
Sistemas de costos y tecnologías avanzadas
Authors: Bellido Sánchez Pedro Alberto 
Published: May 2022

El presente artículo muestra una visión general de los retos a que deben enfrentarse los modernos sistemas de costos o de contabilidad estratégica, en tecnlogías actuales, que emplean principalmente "el justo a tiempo", así como "el control total de la calidad, en la permanente búsqueda de la "productividad" y la "excelencia". Además se describen clara y brevemente las respuestas de hoy, ante tales desafíos para los sistemas de costos o contabilidad de gestión.