bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, Attitude, and Practice Towards Reproductive Health Issue of Adolescents in Rural area, Indonesia: A Cross-sectional Study
Authors: Adjie JM Seno , Kurniawan Andrew Pratama , Surya Raymond 
Published: September 2022

Background:
Indonesia’s population is dominated by adolescents; however, reproductive health (RH) issues significantly affect them. Limited access to information and taboo issues regarding reproductive health are significant problems in Indonesian rural areas.

Objectives:
This study investigates the knowledge, attitudes, and practices (KAP) regarding RH issues among high school adolescents in rural areas in Indonesia and provides information about RH issues.

Methods:
This is a quantitative, pre-and post-workshop evaluation, cross-sectional descriptive study determining the KAP of adolescents regarding reproductive health issues. We used a questionnaire to measure the KAP. It was conducted on all high school students in Mekong 1 High School of Meranti district, Riau province, Indonesia. After filling out the questionnaire, there was a 25-minute workshop to educate them on RH issues. A statistical significance was set at p<0.05

Results:
121 students completed the questionnaire. Most of them were 17 years old lived with parents (93.4%), with their father’s occupation being labor (42.9%) and housewife (89.3%) for their mothers. The median results of their knowledge were low, although they had a positive attitude and mostly had good practice. There were no differences in knowledge and attitude based on class or gender, but there was a difference of practice between genders. The workshop improves their knowledge level significantly.

Conclusion:
High school students in the rural district have low knowledge, positive attitudes, and poor sexual health and reproduction practices. There are five of the 121 students who had sex before. The workshop that had been done significantly increased their knowledge and attitude.
Hoslundia opposita Vahl. - A Promising Source of Bioactive Compounds
against Infectious and Non-infectious Diseases
Authors: Oyeyemi Ifeoluwa T. , Ojo Tunbi D. , Oyeyemi Oyetunde T. 
Published: September 2022

Abstract:
Hoslundia opposita is an aromatic plant of the family Lamiaceae and the only member of
the Hoslundia genus. It is used traditionally for treating HIV/AIDs related diseases, Breast cancer,
gonorrhea, syphilis, appendicitis, epilepsy and convulsion, malaria, etc. A review of relevant literature
on biology, folkloric uses, phytochemistry and pharmacology were done. The electronic databases
searched included Google Scholar, PubMed, Science Direct, Wiley and Springer. Sixteen bioactive
compounds have been isolated from the plants, namely; 3-O-benzoylhosloppone, 3-Ocinnamoylhosloppone,
3-O-benzoylhinokiol, 3-O-benzoylhosloquine, Euscaphic acid, 5,7-
dimethoxy6-methylflavone, Hoslunddiol, Oppositin, 5-O-methylhoslundin, Tectochrysin, Hoslundin,
Hoslunfuranine, 5-O-methylhoslunfuranine, Hosloppin, Hoslundal and Ursolic acid. The
plant, with its phytochemicals, has shown various pharmacological effects such as antimalarial, antidiabetes,
antioxidant, anti-inflammatory, anticancer and immunomodulatory effects. This review
presented scientific findings on the therapeutic potential of Hoslundia opposita against several infectious
and non-infectious diseases. There is a need for further investigation of the mechanism underlying
the therapeutic potential of this plant against various diseases. There is also a need for clinical
trials which will validate its efficacy and safety.
Emergency Visits and Hospitalization After Chat Message, Voice Call, or Video Call for Telehealth in Obstetrics and Gynecology Using Telehealth Service User Data in Japan: Cross-sectional Study
Authors: Sakakibara Koichi , Shigemi Daisuke , Toriumi Rena , Ota Ai , Michihata Nobuaki , Yasunaga Hideo 
Published: September 2022

Background
In obstetric and gynecologic practices, synchronous telehealth services via chat message, voice calls, and video calls have been increasingly equipped to improve patients’ health care accessibility and clinical outcomes. Nevertheless, differences in clinical outcomes between communication tools remain unknown, especially in terms of safety.

Objective
This study compared the occurrence of emergency visits and hospitalization after telehealth services through different communication tools, including chat messages, voice calls, and video calls.

Methods
We collected data on obstetric and gynecologic concerns of women who consulted specialized doctors and midwives through a telehealth consulting service in Japan (Sanfujin-ka Online) between January 1, 2019, and December 31, 2020. The outcomes were emergency visits or hospitalizations at night after the consultation. Chi-square test and multivariate logistic regression analysis were performed to compare the clinical outcomes between the groups who received telehealth services via chat message, voice calls, and video calls.

Results
This study included 3635 participants. The mean age of the participants was 31.4 (SD 5.7) years, and the largest age group (n=2154, 59.3%) was 30-39 years. The numbers (or proportions) of those who received telehealth services via chat message, voice calls, and video calls were 1584 (43.5%), 1947 (53.6%), and 104 (2.9%), respectively. The overall incidence of the outcome was 0.7% (26/3635), including 10 (0.3%) cases of chat message, 16 (0.5%) cases of voice calls, and no video calls. There were no emergency visits that happened due to inappropriate advice. No significant difference in the proportions of the outcomes was observed between the communication tools (P=.55). The multivariate logistic regression analysis showed no significant differences in the outcome between those who used chat message and those who used voice calls (odds ratio 1.63, 95% CI 0.73-3.65).

Conclusions
The communication tools of telehealth services in obstetrics and gynecology did not show a significant difference in terms of emergency visits or hospitalizations after using the service.
To Refer or Not to Refer in Teledermoscopy: Retrospective Study
Authors: Tensen Esmée , van Sinderen Femke , Bekkenk Marcel W , Jaspers Monique W , Peute Linda W 
Published: September 2022

Background
Challenges remain for general practitioners (GPs) in diagnosing (pre)malignant and benign skin lesions. Teledermoscopy (TDsc) supports GPs in diagnosing these skin lesions guided by teledermatologists' (TDs) diagnosis and advice and prevents unnecessary referrals to dermatology care. However, the impact of the availability of TDsc on GPs’ self-reported referral decisions to dermatology care before and after the TDsc consultation is unknown.

Objective
The objective of this study is to assess and compare the initial self-reported referral decisions of GPs before TDsc versus their final self-reported referral decisions after TDsc for skin lesions diagnosed by the TD as (pre)malignant or benign.

Methods
TDsc consultations requested by GPs in daily practice between July 2015 and June 2020 with a TD assessment and diagnosis were extracted from a nationwide Dutch telemedicine database. Based on GP self-administered questions, the GPs’ referral decisions before and their final referral decision after TDsc consultation were assessed for (pre)malignant and benign TD diagnoses.

Results
GP self-administered questions and TD diagnoses were evaluated for 6364 TDsc consultations (9.3% malignant, 8.8% premalignant, and 81.9% benign skin lesions). In half of the TDsc consultations, GPs adjusted their initial referral decision after TD advice and TD diagnosis. Initially, GPs did not have the intention to refer 67 (56.8%) of 118 patients with a malignant TD diagnosis and 26 (16.0%) of 162 patients with a premalignant TD diagnosis but then decided to refer these patients after the TDsc consultation. Furthermore, GPs adjusted their decision from referral to nonreferral for 2534 (74.9%) benign skin lesions (including 676 seborrheic keratosis and 131 vascular lesions).

Conclusions
GPs adjusted their referral decision in 52% (n=3306) of the TDsc consultations after the TD assessment. The availability of TDsc is thus of added value and assists GPs in their (non)referral for patients with skin lesions to dermatology care. TDsc resulted in referrals of patients with (pre)malignant skin lesions that GPs would not have referred directly to the dermatologist. TDsc also led to a reduction of unnecessary referrals of patients with low complex benign skin lesions (eg, seborrheic keratosis and vascular lesions).
Validation of an Electronic Visual Analog Scale App for Pain Evaluation in Children and Adolescents With Symptomatic Hypermobility: Cross-sectional Study
Authors: Maarj Muhammad , Pacey Verity , Tofts Louise , Clapham Matthew , Gironès Garcia Xavier , Coda Andrea 
Published: September 2022

Background
Rapid advances in mobile apps for clinical data collection for pain evaluation have resulted in more efficient data handling and analysis than traditional paper-based approaches. As paper-based visual analogue scale (p-VAS) scores are commonly used to assess pain levels, new emerging apps need to be validated prior to clinical application with symptomatic children and adolescents.

Objective
This study aimed to assess the validity and reliability of an electronic visual analogue scale (e-VAS) method via a mobile health (mHealth) App in children and adolescents diagnosed with hypermobility spectrum disorder/hypermobile Ehlers-Danlos syndrome (HSD/HEDS) in comparison with the traditional p-VAS.

Methods
Children diagnosed with HSD/HEDS aged 5-18 years were recruited from a sports medicine center in Sydney (New South Wales, Australia). Consenting participants assigned in random order to the e-VAS and p-VAS platforms were asked to indicate their current lower limb pain level and completed pain assessment e-VAS or p-VAS at one time point. Instrument agreement between the 2 methods was determined from the intraclass correlation coefficient (ICC) and through Bland–Altman analysis.

Results
In total, 43 children with HSD/HEDS aged 11 (SD 3.8) years were recruited and completed this study. The difference between the 2 VAS platforms of median values was 0.20. Bland–Altman analysis revealed a difference of 0.19 (SD 0.95) with limits of agreement ranging –1.67 to 2.04. An ICC of 0.87 (95% CI 0.78-0.93) indicated good reliability.

Conclusions
These findings suggest that the e-VAS mHealth App is a validated tool and a feasible method of collecting pain recording scores when compared with the traditional paper format in children and adolescents with HSD/HEDS. The e-VAS App can be reliably used for pediatric pain evaluation, and it could potentially be introduced into daily clinical practice to improve real-time symptom monitoring. Further research is warranted to investigate the usage of the app for remote support in real clinical settings.
Influence of Lecithin cholesterol acyltransferase alteration during different pathophysiologic conditions: a 45 years bibliometrics analysis (Preprint)
Authors: Gao Hongliang , Wu Jing , Sun Zhenyu Sun , Zhang FuRong , Shi Tianshu , Lu Ke , Qian Dongfu , Zhao Yinjuan , Qin Jian , Xue Bin 
Published: September 2022

BACKGROUND

Lecithin cholesterol acyltransferase (LCAT) is an important enzyme responsible for free cholesterol (FC) esterification, which is critical for high density lipoprotein (HDL) maturation and the completion of the reverse cholesterol transport (RCT) process. Plasma LCAT activity and concentration showed various patterns under different physiological and pathological conditions. Research on LCAT has grown rapidly over the past 50 years, but there is no bibliometric studies summarizing this field as a whole. This study aimed to use the bibliometric analysis to demonstrate the trends in LCAT publications, thus offering a brief perspective with regard to future developments in this field.

OBJECTIVE

This study aimed to use the bibliometric analysis to demonstrate the trends in LCAT publications, thus offering a brief perspective with regard to future developments in this field.

METHODS

We used the Web of Science Core Collection to retrieve LCAT-related studies published from 1975 to 2020. The data were further analyzed in the number of studies, the journal which published the most LCAT-related researches, co-authorship network, co-country network, co-institute network, co-reference and the keywords burst by CiteSpace V 5.7.

RESULTS

2584 publications contained 55,311 references were used to analyzed. The number of included articles fluctuated in each year. We found that Journal of lipid research published the most LCAT-related researches. Among all the authors who work on LCAT, they tend to collaborate with a relatively stable group of collaborators to generate several major authors clusters which Albers, J. published the most articles (n=53). The United States of America contributed the greatest proportion (n=1036) of LCAT-related researches. The LCAT-related researches have been focused on the vascular disease, lecithin-cholesterol acyltransferase reaction, phospholipid, cholesterol efflux, chronic kidney disease, milk fever, nephrotic syndrome, platelet-activating factor acetylhydrolase, reconstituted lpa-i, reverse cholesterol transport. Four main research frontiers in terms of burst strength for LCAT-related researches including “transgenic mice” ， “oxidative stress”, “risk” and “cholesterol metabolism”need more attention.

CONCLUSIONS

This is the first study that demonstrated the trends and future development in LCAT publications. Further studies should focus on the accurate metabolic process of LCAT dependent or independent of RCT using metabolic marker tracking techniques. It was also well worth to further studying the possibility that LCAT may qualify as a biomarker for risk prediction and clinical treatment.
Effect of home-based exercise programs with e-devices on falls among community-dwelling older adults: a meta-analysis
Authors: Cao Yu-ting , Wang Jian-jie , Yang Yi-ting , Zhu Shi-jie , Zheng Liang-dong , Lu Wei-wei , Zhu Rui , Wu Tao 
Published: September 2022

Aim:To explore the effectiveness of home-based exercise programs with e-devices (HEPEs) on falls among community-dwelling older adults.Methods:Twelve randomized controlled trials were included in the meta-analysis considering four fall-related outcomes.Results:HEPEs significantly reduced the rate of falls (risk ratio: 0.82; 95% CI: 0.72–0.95; p = 0.006) and improved lower extremity strength (mean difference: -0.94; 95% CI: -1.71 to -0.47; p < 0.001). There was a significant improvement favoring HEPEs on balance if the participants were aged >75 years (mean difference: -0.55; 95% CI: -1.05 to -0.05; p = 0.03), or the intervention duration was at least 16 weeks (mean difference: -0.81; 95% CI: -1.58 to -0.05; p = 0.04).Conclusion:HEPEs demonstrated an overall positive effect on falls among community-dwelling older adults.
Techno-Economic Evaluation of a Skimmed Milk Powder Production Process
Authors: Pérez Sánchez Amaury , Olivera Romero Vladimir 
Published: September 2022

Milk powder is a highly demanded food that is used in various ways, both in the industrial area and in everyday life. In the present work, an innovative and unprecedented techno-economic evaluation of a technological proposal for a skimmed milk powder production plant with an annual capacity of 700 tons was carried out through the use of the SuperPro Designer® simulator, in order to know its main economic and profitability indicators under the current economic conditions in Cuba. For economic performance evaluation, the total capital investment, unit production cost, internal rate of return (IRR), net present value (NPV) and project payback time (PT) among other indicators, were determined. A sensitivity study was also accomplished, to determine from what value of the fluid milk unit cost the proposed skimmed milk powder plant begins to be unprofitable. A total capital investment of USD 22 744 000, an annual operating cost of USD 9 884 000, a working capital of USD 647 000 and a unit production cost of USD 352.95 per 25 kg bag were obtained. From the techno-economic results obtained, it can be concluded that the evaluated skimmed milk powder production plant is profitable and feasible due to the values of NPV (USD 14 475 000), IRR (18.98 %) and PT (4.46 years) obtained. The proposed production plant becomes unprofitable from a value of the fluid milk unit cost of USD 1.32/L.
Systematic Review of the Safety and Efficacy of Central Vascular Access Device Securement
Authors: Bell Jon A. , Hawes Michelle , Diloreto Emily , Gibson S. Matthew 
Published: September 2022

Highlights

Abstract

Background:
Central vascular access devices (CVADs) are essential for patient care in modern medicine. Providing access to the central circulation, CVADs allow fluids and medications to be infused rapidly and hemodiluted. The placement of a CVAD requires knowledge of vascular access devices, optimal site selection, infection prevention protocols, and expert techniques to limit potential adverse outcomes. Research has been focused on how to safely and effectively place CVADs, but little effort has been made to investigate the securement of the catheter once it is in place.

Methods:
This systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and registered through PROSPERO. Two systematic searches of the literature were conducted, the first in January 2021 and the second in January 2022, by using multiple medical databases. Of the 1127 titles that met initial inclusion criteria 117 were selected for evaluation and then 39 for study.

Results:
Search results yielded various outcomes, making a direct comparison between studies challenging. However, it was clear that safety and efficacy were not applied to suture-based securement and have not been well researched despite its general use.

Conclusions:
Randomized controlled studies are needed to measure the relative safety and efficacy of different securement modalities, their impact on CVAD complications, and ultimately patient outcomes.
Systematic Review and Network Meta-analysis of Neurostimulation for Painful Diabetic Neuropathy
Authors: Duarte Rui V. , Nevitt Sarah , Copley Sue , Maden Michelle , de Vos Cecile C. , Taylor Rod S. , Eldabe Sam 
Published: September 2022

BACKGROUND
Different waveforms of spinal cord stimulation (SCS) have now been evaluated for the management of painful diabetic neuropathy (PDN). However, no direct or indirect comparison between SCS waveforms has been performed to date.

PURPOSE
To conduct a systematic review and network meta-analysis to evaluate the effectiveness of SCS for PDN.

DATA SOURCES
MEDLINE, CENTRAL, Embase, and WikiStim were searched from inception until December 2021.

STUDY SELECTION
Randomized controlled trials (RCTs) of SCS for PDN were included.

DATA EXTRACTION
Pain intensity, proportion of patients achieving at least a 50% reduction in pain intensity, and health-related quality of life (HRQoL) data were extracted.

DATA SYNTHESIS
Significant reductions in pain intensity were observed for low-frequency SCS (LF-SCS) (mean difference [MD] −3.13 [95% CI −4.19 to −2.08], moderate certainty) and high-frequency SCS (HF-SCS) (MD −5.20 [95% CI −5.77 to −4.63], moderate certainty) compared with conventional medical management (CMM) alone. There was a significantly greater reduction in pain intensity on HF-SCS compared with LF-SCS (MD −2.07 [95% CI −3.26 to −0.87], moderate certainty). Significant differences were observed for LF-SCS and HF-SCS compared with CMM for the outcomes proportion of patients with at least 50% pain reduction and HRQoL (very low to moderate certainty). No significant differences were observed between LF-SCS and HF-SCS (very low to moderate certainty).

LIMITATIONS
Limited number of RCTs and no head-to-head RCTs conducted.

CONCLUSIONS
Our findings confirm the pain relief and HRQoL benefits of the addition of SCS to CMM for patients with PDN. However, in the absence of head-to-head RCT evidence, the relative benefits of HF-SCS compared with LF-SCS for patients with PDN remain uncertain.
Making Diabetes Electronic Medical Record Data Actionable: Promoting Benchmarking and Population Health Improvement Using the T1D Exchange Quality Improvement Portal
Authors: Mungmode Ann , Noor Nudrat , Weinstock Ruth S. , Izquierdo Roberto , Indyk Justin A. , DeSalvo Daniel J. , Corathers Sarah , Demeterco-Berggen Carla , Hsieh Susan , Jacobsen Laura M. , Mekhoubad Allison , Akturk Halis Kaan , Wirsch Anton , Scott Mary Lauren , Chao Lily C. , Miyazaki Brian , Malik Faisal S. , Ebekozien Osagie , Clements Mark , Alonso G. Todd 
Published: September 2022

<p> </p>
<p>This article describes how the T1D Exchange Quality Improvement Collaborative leverages an innovative web platform, the QI Portal, to gather and store electronic medical record (EMR) data to promote benchmarking and population health improvement in a type 1 diabetes learning health system. The authors explain the value of the QI Portal, the process for mapping center-level data from EMRs using standardized data specifications, and the QI Portal’s unique features for advancing population health.</p>
Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Authors: Davies Melanie J. , Aroda Vanita R. , Collins Billy S. , Gabbay Robert A. , Green Jennifer , Maruthur Nisa , Rosas Sylvia E. , Prato Stefano Del , Mathieu Chantal , Mingrone Geltrude , Rossing Peter , Tankova Tsvetalina , Tsapas Apostolos , Buse John B. 
Published: September 2022

<p> </p>
<p>The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the previous consensus statements on the management of hyperglycaemia in type 2 diabetes in adults, published since 2006 and last updated in 2019. The target audience is the full spectrum of the professional healthcare team providing diabetes care in the USA and Europe. A systematic examination of publications since 2018 informed new recommendations. These include additional focus on social determinants of health, the healthcare system and physical activity behaviours including sleep. There is a greater emphasis on weight management as part of the holistic approach to diabetes management. The results of cardiovascular and kidney outcomes trials involving sodium–glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists, including assessment of subgroups, inform broader recommendations for cardiorenal protection in people with diabetes at high risk of cardiorenal disease. After a summary listing of consensus recommendations, practical tips for implementation are provided.</p>