bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication and Applications of Polymeric Nanoparticles for Herbal Drug Delivery and Targeting
Authors: Shree Dipthi , Patra Chinam N. , Sahoo Biswa M. 
Published: August 2022

Background and objective:In the pharmaceutical era, nanoscience and nanotechnology have been revolutionary as substantial and scientific growth with the development of several innovative nanocarriers to amplify the therapeutic worth. In particular, the invention of nanomedicine is impetuous to developing nanocarriers, enabling the phytoconstituents to encapsulate within the smart carrier to boost nanotherapeutics. Thus, herbal drugs molded-in novel nanocarriers have been extensively investigated as they are the most promising drug delivery system. Herbal-based polymeric nanoparticles are the most prominent and emerging polymeric nanocarrier that have gained much research attention in the field of novel drug delivery systems.Methods:In herbal drug delivery technologies, the advancement of phytopharmacological science has led to the elucidation of the composition of phytoconstituents and their biological activities. By fabricating herbal medicaments in nano-size-form, there are considerable chances to circumvent poor bioavailability, in vivo degradation and toxicity, uneven drug distribution, intestinal absorption, and non-specific site of action. The combinatorial strategy of employing both herbal drugs and nanotechnology enables potentiation of the therapeutics, reducing the required dose and unwanted toxic effects. The herbal nanosystem has the potential to convey the active constituents in a controlled manner to the targeted site with greater therapeutic value compared to the conventional system. In this current manuscript, sterling efforts were made to gather information from the existing original research papers using databases viz., Google Scholar, Pubmed, Embase, Scopus, Baidu, Web of Science, etc. Furthermore, painstaking efforts were made to compile and update potential pharmaceutical and cosmeceutical applications of herbal-based polymeric nanoparticles in the form of tables. This article portrays a comprehensive recent finding that formulation scientists are working on novel herbal nanocarriers to pave the way for future research in the field of pharmaceutical nanotechnology.Conclusion:The herbal extracts encapsulated within the nanocapsule or nanosphere are an effective and emerging way for the herbal drug delivery to the intended site of action with pronounced therapeutic worth. Therefore, extensive scientific research is still being carried out in the field of herbal drug technology, which offers several positive aspects to impart the phytoconstituents to the intended sites and is a considerably promising herbal drug delivery system for controlled drug delivery and targeting.
Decentralized Wind Power Forecasting Method Based on Informer
Authors: Li Wei , Yan Yuting , Su Shi , Bai Hao , Yang Yang , Pan Shuhui , Yuan Zhiyong , Chen Jun , Zhao Qindao 
Published: August 2022

Background:
Improving the accuracy of decentralized wind power forecasting has become an important means to ensure the safe and stable operation of the power grid. Traditional
prediction methods cannot meet the requirements of precise wind power prediction for long time
series

Methods:
A decentralized wind power prediction model based on Informer is established. Introducing the model's sparse self-attention mechanism, self-attention distillation mechanism and The
generative decoder model realizes the long-term sequence power prediction of decentralized wind
power.

Results:
The results of the proposed model are analyzed by comparing it with traditional neural
network models such as LSTM and feed-forward neural networks. The root mean square error
(RMSE) can be reduced by up to 6.3%

Conclusion:
It is proved that the Informer model prediction has a lower prediction error and performs better in long-term sequence power pre-tasks.
mHealth Physical Activity Intervention for Individuals With Spinal Cord Injury: Planning and Development Processes
Authors: Lawrason Sarah Victoria Clewes , Brown-Ganzert Lynda , Campeau Lysa , MacInnes Megan , Wilkins C J , Martin Ginis Kathleen Anne 
Published: August 2022

Background
Interventions to support physical activity participation among individuals with spinal cord injury (SCI) are required given this population’s low levels of physical activity and extensive barriers to quality physical activity experiences.

Objective
This study aimed to develop a mobile health intervention, called SCI Step Together, to improve the quantity and quality of physical activity among individuals with SCI who walk.

Methods
Our overarching methodological framework was the Person-Based approach. This included the following 4 steps: conduct primary and secondary research (step 1); design intervention objectives and features (step 2a); conduct behavioral analysis and theory (step 2b); create a logic model (step 3); and complete the SCI Step Together program content and integrated knowledge translation (IKT; step 4), which occurred throughout development. The partnership approach was informed by the SCI IKT Guiding Principles. Three end users pilot-tested the app and participated in the interviews.

Results
Step 1 identified issues to be addressed when designing intervention objectives and features (step 2a) and features were mapped onto the Behavior Change Wheel (step 2b) to determine the behavior change techniques (eg, action planning) to be included in the app. The logic model linked the mechanisms of action to self-determination theory (steps 2/3). Interviews with end users generated recommendations for the technology (eg, comparing physical activity levels with guidelines), trial (eg, emailing participants’ worksheets), and intervention content (eg, removing graded tasks; step 4).

Conclusions
Using the SCI IKT Guiding Principles to guide partner engagement and involvement ensured that design partners had shared decision-making power in intervention development. Equal decision-making power maximizes the meaningfulness of the app for end users. Future research will include testing the acceptability, feasibility, and engagement of the program. Partners will be involved throughout the research process.

Trial Registration
ClinicalTrials.gov: NCT05063617; https://clinicaltrials.gov/ct2/show/NCT05063617
Designing Studies to Inform Tobacco Harm Reduction: Learnings From an Oral Nicotine Pouch Actual Use Pilot Study
Authors: Campbell Chris , Feehan Michael , Kanitscheider Claudia , Makena Patrudu S , Cai Jenny , Baxter Sarah A 
Published: August 2022

Background
Introduction of new tobacco products in the United States, including those that may be lower on the risk continuum than traditional combustible cigarettes, requires premarket authorization by the US Food and Drug Administration and information on the potential impact of the products on consumer behaviors. Efficient recruitment and data capture processes are needed to collect relevant information in a near-to-real-world environment.

Objective
The aim of this pilot study was to develop and test a protocol for an actual use study of a new tobacco product. The product included in this study was a commercially available oral nicotine pouch. Through the process of study design and execution, learnings were garnered to inform the design, execution, analysis, and report writing of future full-scale actual use studies with tobacco products.

Methods
A small sample (n=100) of healthy adult daily smokers of 7 or more cigarettes per day were recruited to participate in an 8-week prospective observational study conducted at 4 geographically dispersed sites in the United States. A smartphone-based customized electronic diary (eDiary) was employed to capture daily tobacco product use, including 1 week of baseline smoking and 6 weeks during which participants were provided with oral nicotine pouches for use as desired.

Results
Online screening procedures with follow-up telephone interviews and on-site enrollment were successfully implemented. Of 100 participants, 97 completed the study, with more than half (59/99, 60%) identifying as dual- or poly-users of cigarettes and other types of tobacco products at baseline. There was more than 90% (91-93/99, 92%-94%) compliance with daily eDiary reporting, and the majority (92/99, 93%) of participants expressed satisfaction with the study processes. Product use data from the eDiary indicated that after an initial period of trial use, pouches per day increased among those continuing to use the products, while per day average cigarette consumption decreased for 82% (79/97) of all study participants. At the end of the week 6, 16% (15/97) of participants had reduced their cigarette consumption by more than half.

Conclusions
The design of this study, including recruiting, enrollment, eDiary use, and oversight, was successfully implemented through the application of a detailed protocol, a user-friendly eDiary, electronically administered questionnaires, and remote monitoring procedures. High-resolution information was obtained on prospective changes in tobacco product use patterns in the context of availability of a new tobacco product. Future, larger actual use studies will provide important evidence supporting the role that alternatives to combustible cigarettes may play in smoking reduction and/or cessation and lowering the population health burden of tobacco and nicotine-containing products.
Technology-Based Innovative Health Care Solutions for Improving Maternal and Child Health Outcomes in Low- and Middle-Income Countries: Systematic Review and Network Meta-analysis
Authors: Rahman Md Obaidur , Yamaji Noyuri , Suzuki Daichi , Sasayama Kiriko , Yoneoka Daisuke , Ota Erika 
Published: August 2022

Background
Technology-based health care interventions (TBIs) are being considered as a promising solution to effectively strengthen maternal and child health (MCH) service uptake in resource-limited settings.

Objective
This study aimed to identify the most effective TBIs that could achieve the best functional MCH outcomes in low- and middle-income countries (LMICs).

Methods
A comprehensive search was performed in January 2021. In all, 2 independent researchers identified randomized controlled trials (RCTs) implemented in LMICs using the Population, Intervention, Comparison, Outcomes framework: Population: healthy pregnant women; Intervention: TBIs; Comparison: usual care or non-TBIs; and Outcomes: MCH outcomes. We estimated the direct, indirect, and relative effects, with their certainty based on the Grading of Recommendations, Assessments, Development, and Evaluations approach, for a wide range of MCH outcomes.

Results
In total, 30 trials with 70,807 participants were included, and 80% had low risk of bias. Our network meta-analysis (NMA) estimates indicated that TBIs, particularly SMS text messaging or phone call with mobile voucher interventions, were likely to be effective in improving MCH outcomes. The 1-way communication intervention was likely to be the most effective for the uptake of ≥4 antenatal care visits (relative risk [RR] 1.81, 95% CI 1.33-2.45; moderate certainty), facility delivery (RR 1.45, 95% CI 1.10-1.91; moderate certainty), early breastfeeding initiation (RR 1.18, 95% CI 1.02-1.37; moderate certainty), and caesarean delivery (RR 0.87, 95% CI 0.84-0.91; low certainty) outcomes; however, 2-way communication intervention was likely to be the most effective for the skilled birth attendance (RR 1.36, 95% CI 1.14-1.63; low certainty), maternal (RR 2.04, 95% CI 1.05-3.96; very low certainty) and infant’s postnatal care use (RR 1.55, 95% CI 1.19-2.04; low certainty), exclusive breastfeeding practice (RR 1.53, 95% CI 1.14-2.05; moderate certainty), and perinatal death (RR 0.51, 95% CI 0.32-0.83; low certainty) outcomes. There was no substantial inconsistency between direct and indirect evidence, but small study effects were detected in the NMA.

Conclusions
Different forms of TBIs have a possibility to improve MCH outcomes in LMICs and can be integrated into the existing health systems based on their priorities. This study suggests the implementation of large-scale, well-designed RCTs in low-income countries due to the limited number of RCTs in the NMA.

Trial Registration
PROSPERO CRD42021239185; https://tinyurl.com/yuvmp35x
Systematic Approaches for Telemedicine and Data Coordination for COVID-19 in Baja California, Mexico
Authors: Castillo Olea Jr Cristian , Vera Hernandez Sr Carlos , Mendias Alarcon Amellaly , Conte Galvan Sr Roberto 
Published: August 2022

Background
In 2019, the State of Baja California had a total population of 3,682,063 inhabitants; in the city of Tijuana, there were only 13 Red Cross ambulances and 1 fire department ambulance to attend to the prehospital emergencies of almost 2 million inhabitants.

Objective
This study aimed to provide information to the public; evaluate COVID-19 in real time; and track regional, municipal, and state-wide data in real time that inform supply chains and resource allocation with the anticipation of a surge in COVID-19 cases.

Methods
Our model is based on human-centric design factors and cross-disciplinary collaborations for the scalable, data-driven enablement of smartphone teleconsultation technologies to link hospitals, clinics, and emergency medical services for point-of-care assessments of COVID-19 testing and subsequent treatment and quarantine decisions.

Results
The Telehealth System handled 28,964 telephone calls in the period from April 1, 2020, to January 30, 2022, and accumulated 20,287 working hours. In total, 13,721 follow-up calls were made to quarantined patients, providing medical and psychological counseling, and 12,643 calls were received and transferred from the 911 system, of which 4964 calls from patients with respiratory symptoms required urgent ambulance dispatch.

Conclusions
Telehealth offers capabilities for remote detection, care, and treatment to help with supervision, surveillance, discovery, and prevention, as well as to mitigate the effects of health care indirectly related to COVID-19.
Investigations on diesel engine characteristics using waste biomass Pyrolysis oil: A study on the effect of compression ratio
Authors: MarshalS Joseph John , Rajamohan Sakthivel , Gnanasundari Kondru , Kumar Gomathi , Sharon Mary Goldena 
Published: August 2022

This work is focussed at studying the compression ratio (CR) effect on the operating characteristics of a diesel engine fuelled with diesel (80%) and pyrolytic oil (20%) blend, derived from Bael de oiled cake at standard conditions. Engine was operated at three CR’s namely 18:1 (higher), 17.5:1 (standard) and 16:1 (lower). For the blended fuel operation at full load, the brake thermal efficiency (BTE) improved by 5% and brake specific energy consumption (BSEC) diminished by 3% as the CR increased from 17.5 to 18. At high CR, the carbon monoxide (CO) and unburnt hydrocarbon (HC) were lowered by 58.3% and 38.5% respectively for blended fuel when compared to diesel at peak load. The nitrogen oxides emission (NOx) increased by 25.7% for blended fuel at peak load and CR of 18:1. On the whole the experimental results suggest that optimum performance of the engine can be attained at CR 18:1.
SISTEM PEMBAYARAN SEWA TANAH PADA PENAMBANGAN EMAS SECARA TRADISIONAL DI KEC. SAWANG DALAM PERSPEKTIF AKAD IJĀRAH BI AL-MANFA’AH
Authors: Mutia Arjayanda  
Published: August 2022

Praktek sewa-menyewa tanah di lokasi penambangan emas di gampong Panton Luas dilakukan oleh masyarakat yang berprofesi sebagai penambang dengan pihak pemilik lahan, karena eksplorasinya harus dilakukan secara legal. Pembayaran sewa lahan galian batuan mengandung emas dilakukan dengan menggunakan bebatuan hasil galian yang dibagi antara pihak penambang dengan pihak pemilik lahan. Namun pembayaran sewa dengan batuan merupakan cost yang tidak ada kepastian nilainya bahkan tidak dapat diestimasikan nilai atau kadar emasnya sebagai biaya sewa. Tujuan penelitian ini yaitu untuk mengetahui mekanisme penetapan harga sewa tanah pada penambangan emas secara tradisional di kecamatan Sawang, bagaimana ketentuan dan kesepakatan dalam pengambilan manfaat atas sewa tanah pada penambangan emas secara tradisional di kecamatan Sawang serta bagaimana perspektif akad ijārah bi al-manfa'ah terhadap praktik sewa-menyewa tanah pada penambangan emas secara tradisional di kecamatan Sawang. Dalam penelitian skripsi ini digunakan jenis penelitian deskriptif analisis dengan metode pengumpulan data dengan library research dan field research.Teknik pengumpulan dengan wawancara dan observasi. Hasil analisis data yang diperoleh bahwa pembayaran sewa tanah dari lahan galian emas di gampong Panton Luas tidak ditetapkan pada saat akad sewa, ujrah yang dibayar pihak penggali bersifat relatif dan biasanya standar yang digunakan tiap sepuluh karung hasil eksplorasi dijatahkan untuk pemilik lahan sebanyak dua goni. Setelah pihak penggali mendapat izin untuk mengeksplor lahan, pihak pemilik lahan tidak membatasi wiayah eksplorasi dan kedalaman galian karena sepenuhnya diserahkan kepada pihak penggali untuk menambang emas di lahan yang yang diekspektasi mengandung logam mulia tersebut. Menurut konsep ijārah bi-al manfaah bentuk akad sewa lahan galian tersebut tidak memenuhi syarat karena para pihak tidak menetapkan ujrah tertentu, kesepakatan yang dibuat lebih mengedepankan sistem bagi hasil, dan hal tersebut lebih tepat dan mengutungkan bagi para pihak.
PEMBINAAN KECERDASAN SPIRITUAL ANAK DALAM KELUARGA
Authors: Dewi Nurma 
Published: August 2022

Tulisan ini berjudul â€œFungsi Keluarga dalam Pembinaan Kecerdasan Spiritual
Anakâ€. Kecerdasan spiritual sangat penting dalam kehidupan manusia apalagi
dalam dunia pendidikan. Karena ia akan memberi kemampuan kepada
manusia untuk membedakan yang baik dengan yang buruk, memberi manusia
rasa moral dan memberi manusia kemampuan untuk memecahkan persoalan
makna dan nilai. Ketiadaan kecerdasan spiritual akan mengakibatkan
hilangnya ketenangan bathin dan pada akhirnya hilangnya kebahagian. Dari
itu, perlunya penanaman kecerdasan spiritual sejak dini pada buah hati, dan itu
dimulai dari lingkungan keluarga terutama orang tua. Dengan kecerdasan
spiritual manusia dapat mengenal jati dirinya dan mengenal Tuhannya. Karena
manusia yang memiliki spiritual yang baik akan memiliki hubungan yang kuat
dengan Allah, sehingga akan berdampak pula kepada kepandaian dalam
berinteraksi dengan manusia. Permasalahan pokok penelitian ini adalah
bagaimana peran keluarga dalam membina kecerdasan spiritual anak, langkahlangkah
apa saja yang dilakukan keluarga dalam pembinaan kecerdasan
spiritual anak. Adapun tujuan penulis mengangkat sebuah karangan ini adalah
untuk mengetahui peran keluarga dalam membina kecerdasan spiritual anak,
untuk mengetahui langkah-langkah yang dilakukan keluarga dalam
pembinaan kecerdasan spiritual anak. Untuk sampai pada tujuan penelitian ini,
maka penulis menggunakan metode deskriptif analisis yaitu penelitian
terhadap fakta-fakta yang ada sekarang dan melaporkan seperti apa yang
terjadi. Untuk pengumpulan data dilakukan kajian kepustakaan (Library
Research) baik terhadap literatur-literatur yang mendukung kajian ini. Hasil
penelitian menunjukkan bahwa fungsi keluarga dalam pembinaan kecerdasan
spiritual antara lain meliputi, fungsi edukatif, sosialisasi, afeksi, religius,
ekonomis, rekreasi dan bioligis. Secara keseluruhan keluarga mempunyai peran
yang sangat besar dalam mencendaskan anak-anaknya. Karena keluarga
merupakan lembaga pendidikan utama dan pertama yang di dapat oleh anak.
THE GOLDEN AGE : MASA EFEKTIF MERANCANG KUALITAS ANAK
Authors: Uce Loeziana 
Published: August 2022

Mencetak anak sukses bukan hanya tergantung pada lembaga pendidikan
formal, melainkan bisa kita mulai dengan memberikan pendidikan di dalam
keluarga sejak usia dini. Satu diantara faktor penentu keberhasilan mencetak
anak yang berkualitas adalah dengan memanfaatkan suatu kesempatan emas,
atau masa keemasan dalam periodisasi tumbuh kembanh mausia atau yang
dalam kajian periodisasi pertumbuhan dan perkembangan manusia. dikenal
dengan istilah The Golden Age. Dari berbagai penelitian ditemukan bahwa The
Golden Age ini terdapat pada masa konsepsi,yakni sejak manusia masih
sebagai janin dalam Rahim ibunya hingga beberapa tahun pertama
kelahirannya yang diistilahkan dengan usia dini. Dalam kajian mengenai The
golden age yang berarti masa keemasan dalam periodisasi kehidupan ini,
ternyata peranannya mengambil porsi cukup besar dalam menentukan kualitas
manusia. Dari berbagai penelitian diketahui bahwa the Golden Age merupakan
masa yang sangat efektif dan urgen untuk dilakukannya optimalisasi berbagai
potensi kecerdasan yang dimiliki oleh anak manusia untuk menuju Sumber
Daya Manusia yang berkualitas. Keberhasilan ataupun kegagalan
pengembangan kecerdasan intelektual, emosional dan spiritual seorang anak
sering terletak pada tingkat kemampuan dan kesadaran orang tua dalam
memanfaatkan peluang pada masa keemasan ini. Tingkat optimalisasi peran
pengasuhan orang tua yang kontinyu dan konsisten terhadap pertumbuhan
dan perkembangan anak pada priode tersebut sangat menentukan kualitas
anak dikemudian hari. Pengasuhan yang dimaksud adalah perawatan dan
pendidikan , selain dengan pemberian nutrisi makanan yang memadai
untuk pengembangan kecerdasan intelektual, juga nutrisi pemberian non
materi untuk pengembangan kecerdasan emosi dan spiritual yang dilakukan
melalui kontinuitas dan konsistensi pengasuhan, pendidikan serta penerapan
disiplin dalam internalisasi dan sosialisasi ajaran agama , nilai-nilai moral,
sosial dan budaya pada periode the golden age tersebut.
PENGEMBANGAN MEDIA PAPAN PINTAR HURUF UNTUK MENGENALKAN HURUF ABJAD PADA ANAK USIA 4-5 TAHUN
Authors: Heliati Fajriah Cut Maranda Suryanti, Putri Rahmi, 
Published: August 2022

Permasalahan yang terdapat di PAUD Ibnu Sina adalah terbatasnya media pembelajaran dalam menunjang proses belajar mengajar sehingga hal tersebut menyebabkan perkembangan bahasa keaksaraan anak kurang optimal seperti anak-anak mengalami kesulitan dalam membedakan bunyi dan bentuk antara huruf B,D,F,P,M,N,V,W,S dan Z. Penelitian ini bertujuan untuk mengembangkan dan menghasilkan sebuah media papan pintar huruf yang layak untuk membantu anak dalam mengenal huruf abjad. Penelitian ini merupakan penelitian R&D dengan model ADDIE yang terdiri dari 5 tahap yaitu, Analysis, Design, Development, Implementasi, dan Evaluation. Berdasarkan hasil uji kelayakan pengembangan media papan pintar huruf oleh ahli materi dengan skor persentase 96,87% termasuk dalam kategori “Sangat Layak”, penilaian ahli media dengan skor 77,27% termasuk dalam kategori “Layak”. Berdasarkan hasil uji kepraktisan yang dilakukan di PAUD Ibnu Sina dapat disimpulkan bahwa media papan pintar huruf untuk mengenalkan huruf abjad pada anak usia 4-5 tahun “Layak” digunakan dan diterapkan dalam pembelajaran sesuai dengan hasil penilaian lembar observasi pada anak dengan skor 85,71%.