bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embodying the avatar of an omnipotent agent modulates the perception of one’s own abilities and enhances feelings of invulnerability
Authors: Frisanco Althea , Schepisi Michael , Tieri Gaetano , Aglioti Salvatore Maria 
Published: December 2022

AbstractImmersive virtual reality can give people the illusion of owning artificial bodies (i.e., avatars) and controlling their actions. Tellingly, people appear to adhere to the newly embodied entities not just on the basis of physical traits but also behaving accordingly with the hallmarks of the represented characters. In two studies we pushed the limits of this process by testing if one’s own sense of power could be affected by embodying the anthropomorphic representation of the Christian God, that is considered an omnipotent entity. A human Muscled and a Normotype avatar were used as controls. Results showed that participants embodying the God-avatar: (i) reacted to a threatening event compromising their physical safety by exhibiting a lower skin conductance response and heart rate deceleration compared to the Normotype-control avatar (Study 1); (ii) estimated they had more physical abilities compared to both the Normotype-control and the Muscled-control avatars (Study 2). Taken together, our findings suggest that embodying an omnipotent agent may exert an influence on people’s perception of their own limits and capabilities, nourishing feelings of physical invulnerability and strength. Our study indicates that effectively embodying virtual role models may boost achievements and have translational implications in the field of empowerment.
Identification and characterization of learning weakness from drawing analysis at the pre-literacy stage
Authors: Dui Linda Greta , Lomurno Eugenio , Lunardini Francesca , Termine Cristiano , Campi Alessandro , Matteucci Matteo , Ferrante Simona 
Published: December 2022

AbstractHandwriting learning delays should be addressed early to prevent their exacerbation and long-lasting consequences on whole children’s lives. Ideally, proper training should start even before learning how to write. This work presents a novel method to disclose potential handwriting problems, from a pre-literacy stage, based on drawings instead of words production analysis. Two hundred forty-one kindergartners drew on a tablet, and we computed features known to be distinctive of poor handwriting from symbols drawings. We verified that abnormal features patterns reflected abnormal drawings, and found correspondence in experts’ evaluation of the potential risk of developing a learning delay in the graphical sphere. A machine learning model was able to discriminate with 0.75 sensitivity and 0.76 specificity children at risk. Finally, we explained why children were considered at risk by the algorithms to inform teachers on the specific weaknesses that need training. Thanks to this system, early intervention to train specific learning delays will be finally possible.
Utilizing MALDI-TOF MS and LC-MS/MS to access serum peptidome-based biomarkers in canine oral tumors
Authors: Ploypetch Sekkarin , Jaresitthikunchai Janthima , Phaonakrop Narumon , Sakcamduang Walasinee , Manee-in Sukanya , Suriyaphol Prapat , Roytrakul Sittiruk , Suriyaphol Gunnaporn 
Published: December 2022

AbstractTumors frequently found in dogs include canine oral tumors, either cancerous or noncancerous. The bloodstream is an important route for tumor metastasis, particularly for late-stage oral melanoma (LOM) and late-stage oral squamous cell carcinoma (LOSCC). The present study aimed to investigate serum peptidome-based biomarkers of dogs with early-stage oral melanoma, LOM, LOSCC, benign oral tumors, chronic periodontitis and healthy controls, using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and liquid chromatography tandem mass spectrometry. A principal component analysis plot showed distinct clusters among all groups. Four peptides were identified, including peptidyl-prolyl cis-trans isomerase FKBP4 isoform X2 (FKBP4), steroid hormone receptor ERR1 (ESRRA or ERRA), immunoglobulin superfamily member 10 (IGSF10) and ATP-binding cassette subfamily B member 5 (ABCB5). FKBP4, ESRRA and ABCB5 were found to be overexpressed in both LOM and LOSCC, whereas IGSF10 expression was markedly increased in LOSCC only. These four proteins also played a crucial role in numerous pathways of cancer metastasis and showed a strong relationship with chemotherapy drugs. In conclusion, this study showed rapid screening of canine oral tumors using serum and MALDI-TOF MS. In addition, potential serum peptidome-based biomarker candidates for LOM and LOSCC were identified.
Adaptations by the coral Acropora tenuis confer resilience to future thermal stress
Authors: Hazraty-Kari Sanaz , Tavakoli-Kolour Parviz , Kitanobo Seiya , Nakamura Takashi , Morita Masaya 
Published: December 2022

AbstractElevated temperatures cause coral bleaching and reef degradation. However, coral may have strategies to survive by reproducing more heat-tolerable larvae. We examine the direct and carryover effects of thermal stress on fecundity and fitness in the reef-building coral Acropora tenuis. Fragments from the same colony are subjected to control temperature (~27.5 °C) or heat stress (~31 °C) for ten days. We then examine the fecundity of adults (egg number and size) and the thermal tolerance of larvae and recruits (survival rates, growth, and size). The stressed fragments show a trade-off in egg production, an increase in egg number but a decrease in size. In addition, larvae and recruits from the stressed colony show marginally higher survival rates in the higher water temperature but do not differ in the control condition. Therefore, corals produce more heat-resistant larvae and recruits after they experience heat stress, which may improve coral reef resilience.
Single cell RNA sequencing of the adult Drosophila eye reveals distinct clusters and novel marker genes for all major cell types
Authors: Yeung Kelvin , Bollepogu Raja Komal Kumar , Shim Yoon-Kyung , Li Yumei , Chen Rui , Mardon Graeme 
Published: December 2022

AbstractThe adult Drosophila eye is a powerful model system for phototransduction and neurodegeneration research. However, single cell resolution transcriptomic data are lacking for this tissue. We present single cell RNA-seq data on 1-day male and female, 3-day and 7-day old male adult eyes, covering early to mature adult eyes. All major cell types, including photoreceptors, cone and pigment cells in the adult eye were captured and identified. Our data sets identified novel cell type specific marker genes, some of which were validated in vivo. R7 and R8 photoreceptors form clusters that reflect their specific Rhodopsin expression and the specific Rhodopsin expression by each R7 and R8 cluster is the major determinant to their clustering. The transcriptomic data presented in this report will facilitate a deeper mechanistic understanding of the adult fly eye as a model system.
Deep learning models for predicting RNA degradation via dual crowdsourcing
Authors: Wayment-Steele Hannah K. , Kladwang Wipapat , Watkins Andrew M. , Kim Do Soon , Tunguz Bojan , Reade Walter , Demkin Maggie , Romano Jonathan , Wellington-Oguri Roger , Nicol John J. , Gao Jiayang , Onodera Kazuki , Fujikawa Kazuki , Mao Hanfei , Vandewiele Gilles , Tinti Michele , Steenwinckel Bram , Ito Takuya , Noumi Taiga , He Shujun , Ishi Keiichiro , Lee Youhan , Öztürk Fatih , Chiu King Yuen , Öztürk Emin , Amer Karim , Fares Mohamed ,   Eterna Participants, Das Rhiju 
Published: December 2022

AbstractMedicines based on messenger RNA (mRNA) hold immense potential, as evidenced by their rapid deployment as COVID-19 vaccines. However, worldwide distribution of mRNA molecules has been limited by their thermostability, which is fundamentally limited by the intrinsic instability of RNA molecules to a chemical degradation reaction called in-line hydrolysis. Predicting the degradation of an RNA molecule is a key task in designing more stable RNA-based therapeutics. Here, we describe a crowdsourced machine learning competition (‘Stanford OpenVaccine’) on Kaggle, involving single-nucleotide resolution measurements on 6,043 diverse 102–130-nucleotide RNA constructs that were themselves solicited through crowdsourcing on the RNA design platform Eterna. The entire experiment was completed in less than 6 months, and 41% of nucleotide-level predictions from the winning model were within experimental error of the ground truth measurement. Furthermore, these models generalized to blindly predicting orthogonal degradation data on much longer mRNA molecules (504–1,588 nucleotides) with improved accuracy compared with previously published models. These results indicate that such models can represent in-line hydrolysis with excellent accuracy, supporting their use for designing stabilized messenger RNAs. The integration of two crowdsourcing platforms, one for dataset creation and another for machine learning, may be fruitful for other urgent problems that demand scientific discovery on rapid timescales.
Railway car routing optimization based on the coordinated utilization of station‐line capacities
Authors: Guangye Li , He Shiwei , Song Rui , Song Zilong , Xue Shouqiang 
Published: December 2022

AbstractTo optimize railway car routing based on balanced station‐line capacities, thereby improving railway freight traffic organization efficiency, and reducing transportation costs, a railway car routing optimization model based on the coordinated utilization of station‐line capacities was developed. Based on the theory of the membership function in fuzzy mathematics, the level of railway station‐line coordination based on capacity utilization was presented. The occupancy of a railway line by each car was taken as a binary decision variable. Using a set of deviation constraints, the deviation between the station‐line flow of the railway network and the utilization of a certain level was expressed in the form of decision variables that were then penalized to different degrees in the objective function. The total transportation cost and the penalty cost were taken as the objective function for minimization. Based on the characteristics of the fuzzy membership degree, the relationship between the penalty for capacity deviation and the membership function in the optimization model was analyzed, and the calculation method of the penalty for the capacity deviation considering the membership function was presented. An adaptive large‐scale neighbourhood search (ALNS) algorithm was designed to solve the model, and its effectiveness was verified. An actual 36‐station railway network was used to validate the proposed railway car routing optimization model through comparison with existing models. The optimization results showed that, at the expense of increasing the transportation cost by 1.05%, the coordination penalty cost was reduced by 11.24%, the overall cost was reduced by 3.21%, and most of the situation with 90% utilization rate of stations and lines in the railway network was eliminated. The model proposed in this paper can help reduce the pressure on lines and stations with tight capacity in the network, improve the utilization of virtual lines and stations and coordination of station‐line capacities.
Kardiologische Rehabilitation
Authors: Schwaab Bernhard 
Published: December 2022

AbstractA scientific guideline has been developed to update and harmonize exercise based
cardiac rehabilitation (CR) in German speaking countries of Europe. It addresses all
aspects of CR including indications, contents and delivery. Four meta-analyses were
performed to evaluate the prognostic effect of CR after acute coronary syndrome
(ACS), after coronary bypass grafting (CABG), in patients with systolic heart
failure (HFrEF), and to define the effect of psychological interventions during CR.
Other indications for CR were based on a predefined semi-structured literature
search and recommendations were established by a formal consenting process. CR is
associated with a significant reduction in all-cause mortality in patients after ACS
and CABG, whereas HFrEF-patients benefit in terms of exercise capacity and
health-related quality of life. Patients with other cardiovascular diseases such as
heart valve surgery or intervention, adults with congenital heart disease and
peripheral arterial disease also benefit from CR-participation, but the scientific
evidence is less clear. There is increasing evidence that the beneficial effect of
CR strongly depends on “treatment intensity” including medical
supervision, modulation of cardiovascular risk factors, information and education,
and a minimum of individually adapted exercise volume. Additional psychologic
interventions (PI) should be performed on the basis of individual needs. There was a
trend towards reduction of depressive symptoms for “distress
management” and “lifestyle changes” for PI. Patient
education is able to increase patients` knowledge and motivation as well as
behavior changes regarding physical activity, dietary habits and smoking cessation.
Diversity-sensitive structures should be established to interact with the needs of
special patient groups and gender issues. This guideline reinforces the substantial
benefit of CR in specific cardiac indications, and it points out the minimal
therapeutic needs in CR-delivery.
Personelle Zusammensetzung klinischer Ernährungsteams in
Deutschland
Authors: Girsemihl Caroline , Blumenschein Birgit 
Published: December 2022

Zusammenfassung
Hintergrund Eine zunehmende Anzahl an ernährungstherapeutisch
ausgerichteten Studiengängen in Deutschland verspricht einen wachsenden
Markt an Ernährungsfachkräften. Inwiefern die verschiedenen
Berufs- und Studienabschlüsse bereits auf dem Arbeitsmarkt integriert
werden, wurde in dieser Arbeit exemplarisch für klinische
Ernährungsteams erfasst.
Methoden Mit einem standardisierten halboffenen Fragebogen wurden
Ernährungsteams in deutschen Kliniken zur Zusammensetzung des eigenen
Teams befragt. Die Erstellung des Fragebogens wurde mit dem Portal maQ-Online
durchgeführt und die Auswertung der Daten fand in Excel statt.
Ergebnisse Insgesamt haben 30 verschiedene Teammitglieder und
Teamleitungen aus 19 verschiedenen Ernährungsteams aus neun
Bundesländern in Deutschland teilgenommen. Dabei kam heraus, dass
Ärzte und Ernährungsfachkräfte regelhaft Teil in
klinischen Ernährungsteams sind. Die Profession der
Diätassistenz wies unter den Ernährungsfachkräften
(n=29) die größte Zugehörigkeit auf, verglichen
mit den Professionen Ökotrophologie und Ernährungswissenschaft
(n=8; n=9).
Schlussfolgerung Klinische Ernährungsteams in Deutschland weisen
eine heterogene und dabei überwiegend interprofessionelle
Zusammensetzung auf, jedoch erfüllen die Teams derzeit nicht immer die
deutschen und/oder europäischen Leitlinienempfehlungen zur
Zusammensetzung der klinischen Ernährungsteams. Neuere
ernährungstherapeutisch ausgerichtete Studienabschlüsse,
Ökotrophologie und Ernährungswissenschaft exklusive, finden
derzeit wenig Berücksichtigung in diesen Teams.
Jahresrückblick HaMiPla
Authors: Giunta Riccardo 
Published: December 2022

Liebe Leserinnen und LeserAuch im dritten Jahr der Covid-19 Pandemie haben uns die Folgen in den Kliniken und
Praxen weiterhin beeinträchtigt. Hinzu kommen schwere Krisen durch den Krieg
in der Ukraine mit der Behandlung von Kriegsverletzten, die plastisch-chirurgische
Eingriffe benötigen sowie die daraus resultierende Energiekrise und die
Inflation. Alles dies hat auch erheblichen Einfluss auf unser chirurgisches
Fachgebiet.
Vegane und vegetarische Lebensmittel aus rechtlicher
Perspektive
Authors: Hartwig Stefanie , Sina Christian , Smollich Martin 
Published: December 2022

Zusammenfassung
Einleitung Aufgrund der in den letzten Jahren stark gestiegenen
Vermarktung von vegetarischen und veganen Alternativprodukten zu tierischen
Lebensmitteln ergeben sich zahlreiche lebensmittelrechtliche Fragestellungen,
die sowohl die Zusammensetzung der Lebensmittel an sich als auch Aspekte der
Produktkennzeichnung betreffen. Ziel des vorliegenden Übersichtsartikels
ist es, diese Fragestellungen und die dafür bestehenden rechtlichen
Vorgaben bzw. den aktuellen Diskussionsstand umstrittener Fragen unter
Zugrundelegung der geltenden Rechtsnormen, der Rechtsprechung und der
untergesetzlichen Vorgaben darzustellen.
Methoden Die relevanten Rechtsvorschriften wurden über offizielle
europäische und deutsche Datenbanken recherchiert. Die untergesetzlichen
Vorgaben wurden über Webseiten des Bundesministeriums der Justiz, des
Bundesministeriums für Ernährung und Landwirtschaft und des
Bundesamtes für Verbraucherschutz recherchiert. Die
Rechtsprechungsrecherche erfolgte über die juristische Datenbank
Beck-online und über die Rechtsprechungsdatenbanken einzelner
Bundesländer. Die Recherche erfolgte nach Suchbegriffen, die für
die rechtlichen Fragestellungen im Zusammenhang mit Tierersatzerzeugnissen
relevant sind.
Ergebnisse Es gibt bislang keine gesetzliche Definition für vegane
und vegetarische Lebensmittel. Daher wird in Deutschland auf die nicht
rechtsverbindliche Definition der Begriffe „vegan“ und
„vegetarisch“ in den Leitsätzen der deutschen
Lebensmittelbuchkommission zurückgegriffen. Hieraus ergeben sich
zahlreiche lebensmittelrechtliche Implikationen.
Diskussion Bei der Definition der Begriffe „vegan“ und
„vegetarisch“ ist es legitim, angesichts der fehlenden
Legaldefinition auf die Leitsätze der deutschen
Lebensmittelbuchkommission zurückzugreifen. Bei der Kennzeichnung und
dem Vertrieb solcher Erzeugnisse sind zudem allgemeine lebensmittelrechtliche
Vorschriften zu berücksichtigen, und zwar insbesondere
Irreführungsvorschriften und die Vorgaben zum Schutz der Bezeichnung von
Milcherzeugnissen.
Comparison of Patients Satisfaction with Direct to Implant versus Latissimus Dorsi Flap with Implant Breast Reconstruction Using Breast-Q
Authors: Kim Ji Min , Song Woo Jin , Kang Sang Gue 
Published: December 2022

AbstractBackground The latissimus musculocutaneous flap (LD flap) is a useful option for breast reconstruction following mastectomy. It has the advantage of obtaining sufficient tissue padding and natural shape by using autologous tissue. However, with the emergence of the skin-sparing mastectomy technique and artificial dermis matrix, direct-to-implant (DTI) breast reconstruction has become the first choice of surgery. The purpose of this study was to compare the satisfaction levels of patients who underwent DTI and LD flap with implant using patient-reported Breast-Q results.Methods A retrospective study was performed reviewing the records of 49 women who underwent immediate breast reconstruction with DTI or LD flap with implant and responded to the BREAST-Q questionnaire after the operation. The patient-reported breast-Q results were analyzed and correlated to the demographic information and intraoperative information.Results A total of 26 patients who underwent reconstruction with LD flap with implant and 23 patients with DTI were identified and responded to the questionnaire after an average of 32.3 and 10.4 months postoperation, respectively. According to the patient response to the breast-q values, satisfaction with breast was 60.0 and 57.0 points, psychosocial well-being 61.0 and 60.0 points, and sexual well-being 41.0 and 43.0 points in the two groups. Overall, there was no significant difference in the breast-Q score between the two groups.Conclusion Patients who underwent DTI breast reconstruction seemed equally satisfied with the appearance and outcome of their breast reconstruction compared with LD flap with implant. Therefore, it appears that DTI is adequately replacing LD with implant.
Oral Conditions as Risk Factors for Low Oral Health-Related Quality of Life Among the Elderly Population in Yogyakarta, Indonesia
Authors: Agustina Dewi , Hanindriyo Lisdrianto , Chrismawaty Bernadetta Esti , Naritasari Fimma 
Published: December 2022

Abstract
Objective Approximately 70% of the elderly population living in Yogyakarta, Indonesia, has a low oral health-related quality of life (OHRQoL). This study aimed to identify the risk factors for low OHRQoL in the elderly population of Yogyakarta.
Materials and Methods Oral Hygiene Index Simplified (OHI-S), Community Periodontal Index, Decayed, Missing, and Filled Teeth (DMFT) Index, and the number of natural occluding pairs (NOP) were assessed for 153 participants aged ≥ 60 years. Xerostomia, hyposalivation, and OHRQoL were also examined using Xerostomia Inventory (XI), unstimulated spitting whole saliva collecting method, and Geriatric Oral Health Assessment Index (GOHAI) questionnaire, respectively. OHRQoL was categorized as low, moderate, and high.
Statistical Analysis Bivariate and multivariate tests were conducted to identify the risk factors for low OHRQoL.
Results Initial analysis of characteristics of participants revealed that hyposalivation, xerostomia, periodontal pocket, high DMFT, NOP ≤ 5, poor OHI-S, and low OHRQoL were experienced by 40 (26.1%), 92 (60.1%), 39 (25.5%), 110 (71.9%), 112 (73.2%), 44 (28.8%), and 108 (70.6%) participants, respectively. Relative risk (RR) and p values for hyposalivation, xerostomia, periodontal pocket, high DMFT, NOP ≤5, and poor OHI-S were found to be at 1.573 (CI 0.681–3.637) and 0.225; 2.532 (CI 1.255–5.108) and 0.006; 0.846 (CI 0.391–1.830) and 0.606; 1.759 (CI 0.843–3.670) and 0.110; 1.133 (CI 0.522–2.461) and 0.008; and 2.723 (CI 1.293–5.734) and 0.632, respectively. Multivariate tests showed that xerostomia and NOP ≤5 had RR of 2.519 (CI 1.221–5.195) and 2.536 (CI 1.175–5.477), respectively.
Conclusions Overall, elders with xerostomia or NOP ≤ 5 had 2.5 times higher risk of having a low OHRQoL.
Periodontal Disease and Pregnancy: Correlation with Underweight Birth
Authors: Minervini Giuseppe , Basili Manuele , Franco Rocco , Bollero Patrizio , Mancini Maura , Gozzo Lucia , Romano Giovanni Luca , Marrapodi Maria Maddalena , Gorassini Francesca , D'Amico Cesare , Pedullà Eugenio , Fiorillo Luca 
Published: December 2022

AbstractPeriodontal disease is a risk factor for many systemic diseases including preterm birth and underweight birth. The purpose of this systematic review is to analyze the literature and to highlight any clinical correlation. Information sources such as PubMed, MEDLINE, and Web of Science were consulted to obtain our results with these keywords “periodontal disease,” “pregnancy,” “weight loss” using the connector “AND.” After the first screening by authors, only 27 articles were included in this review. From the analysis of the literature, it was noted that the presence of periodontal disease could have a correlation with underweight birth. Surely, control oral hygiene and oral health is essential during pregnancy to reduce risks, and these results should be essential in establishing a protocol to be maintained during pregnancy.
The Effect of Caries on the Chewing Ability of Children: A Scoping Review
Authors: Bramantoro Taufan , Irmalia Wahyuning Ratih , Santoso Cornelia Melinda Adi , Mohd Nor Nor Azlida , Utomo Haryono , Ramadhani Aulia , Kristanti Risma Aprinda , Nugraha Alexander Patera 
Published: December 2022

AbstractChildhood caries might have several effects on the children's general health and growth, including chewing ability. This study aims to identify the evidences found regarding the effect of caries on the chewing ability of children through a scoping review. A scoping review literature search was performed in three databases (Scopus, PUBMED, and Web of Science) without restricting the publicized year. The selected articles were using human as its subjects and aiming to analyze the effects of caries on mastication ability in children. Ten articles matched the inclusion criteria of this review. All the articles suggested a deleterious effect of caries on masticatory performance, maximum bite force, swallowing threshold, and even masticatory behavior. Two of them stated that the effect was reversible by giving dental treatment. This scoping review concludes a negative effect of caries on the children's chewing ability.