bluuebunny/crossref_metadata_2025_split huggingface dataset:
GERENCIAMENTO DE RECEITA (RM) E BUSINESS ANALYTICS (BA) COMO UM RECURSO ESTRATÉGICO ORGANIZACIONAL
Authors: Cavalcanti Claudia 
Published: February 2022

Objetivo deste artigo é compreender como Business Analytics é identificado como um recurso estratégico no contexto do Gerenciamento de Receita em uma companhia aérea. Nesse âmbito, para responder à questão central desta pesquisa optou-se pela condução de uma pesquisa qualitativa. O processo de coleta de dados foi realizado por meio de observação direta (não participante), de entrevistas e de análise documental. Para a análise de dados, foi realizada uma análise de conteúdo pelo método de análise em espiral de Creswell (2013). Foi possível avançar na abordagem da Visão Baseada em Recursos ao fazer uma articulação teórica entre o campo de Business Analytics (BA) e Gerenciamento de Receita (RM). Dentro das categorias de análise encontradas, cada recurso de capital humano, organizacional e físico foi descrito na rotina da área de Gerenciamento de Receita. Ao descrever essa rotina, foi possível identificar, dentro do modelo VRIO (BARNEY, 1995), como cada atributo foi evidenciado ao buscar garantir a eficiência e eficácia dos recursos que são utilizados pela organização.
The Case of the Red Extremities
Authors: Abarikwu Kelechi , Komara James , Urumov Andrej 
Published: February 2022

Case Presentation: A 37-year-old man with severe obstructive sleep apnea presented to the emergency department with burning pain, redness and swelling in his hands and feet, worsening for several weeks. Pertinent laboratory studies revealed polycythemia.
Discussion: Erythromelalgia is a clinical diagnosis characterized by painful burning, erythema, warmth, and edema usually involving the distal extremities. Therapeutic goals are focused on symptom reduction, while also managing the underlying condition in cases of secondary erythromelalgia. Pharmacological and non-pharmacological therapies have proven to be of limited success.
Scrotal Pain Caused by a Segmental Testicular Infarct
Authors: Muradian Michael , Fox Stephen , Barish Patrice , Todd Brett 
Published: February 2022

Case Presentation: A 44-year-old Black male presented to the emergency department with left scrotal pain. His initial workup did not identify an etiology of his symptoms; however, he returned the following day with worsening pain and a radiology-performed ultrasound then revealed a segmental testicular infarct.
Discussion: Segmental testicular infarcts are a rare, often idiopathic, source of scrotal pain. Diagnosis is made by ultrasound, and repeat imaging may be required if not apparent on initial evaluation. Management is typically conservative although some require surgical intervention.
A Case Report of Prolonged Anaphylaxis after COVID-19 Vaccine
Authors: Armstrong Lisa , Maguire Nicole 
Published: February 2022

Introduction: As the medical community and world have combatted the coronavirus disease 2019 (COVID-19) pandemic, a significant advance was the development of a vaccine against the virus that has already claimed over 4.5 million lives worldwide. Vaccines manufactured by Pfizer-BioNTech and Moderna were the first two COVID-19 vaccines given emergency use authorization by the United States Food and Drug Administration. Preliminary data demonstrated not only the vaccines’ efficacy rates of greater than 95% after a second dose, but also marked safety. Initial data showed only 21 cases of anaphylaxis of greater than 1.8 million doses administered. The majority of those patients had a history of anaphylaxis and presented within the first 15 minutes after administration of the vaccine.
Case Report: We describe a patient who had an anaphylactic reaction to her second dose of the Pfizer BioNTech severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) vaccine with no prior history of allergic reactions or anaphylaxis. This reaction required multiple doses of epinephrine and a four-day hospitalization. We review both the available reports of anaphylaxis to the SAR CoV-2 vaccine and information on other prolonged cases of anaphylaxis.
Conclusion: Our case report is unique in that the patient, despite no prior history of anaphylaxis, had a prolonged course requiring a four-day hospitalization. To our knowledge this is one of the first case reports of prolonged anaphylaxis after the second dose of Pfizer BioNTech COVID-19 vaccine in a patient with no history of prior anaphylaxis.
Star Power
Authors: Bécoulet Alain 
Published: February 2022

A concise and accessible explanation of the science and technology behind the domestication of nuclear fusion energy.
Nuclear fusion research tells us that the Sun uses one gram of hydrogen to make as much energy as can be obtained by burning eight tons of petroleum. If nuclear fusion—the process that makes the stars shine—could be domesticated for commercial energy production, the world would gain an inexhaustible source of energy that neither depletes natural resources nor produces greenhouse gases. In Star Power, Alan Bécoulet offers a concise and accessible primer on fusion energy, explaining the science and technology of nuclear fusion and describing the massive international scientific effort to achieve commercially viable fusion energy.
Bécoulet draws on his work as Head of Engineering at ITER (International Thermonuclear Experimental Reactor) to explain how scientists are trying to “put the sun in a box.” He surveys the history of nuclear power, beginning with post–World War II efforts to use atoms for peaceful purposes, and describes how energy is derived from fusion, explaining that the essential principle of fusion is based on the capacity of nucleons (protons and neutrons) to assemble and form structures (atomic nuclei) in spite of electrical repulsion between protons, which all have a positive charge. He traces the evolution of fusion research and development, mapping the generation of electric current though fusion.
The ITER project marks a giant step in the development of fusion energy, with the potential to demonstrate the feasibility of a nuclear fusion reactor. Star Power offers an introduction to what may be the future of energy production.
Cathepsin S are involved in human carotid atherosclerotic disease progression, mainly by mediating phagosomes: bioinformatics and in vivo and vitro experiments
Authors: Wang Hailong , Jiang Haiying , Cheng Xian Wu 
Published: February 2022

Background
Atherosclerosis emerges as a result of multiple dynamic cell processes including endothelial damage, inflammatory and immune cell infiltration, foam cell formation, plaque rupture, and thrombosis. Animal experiments have indicated that cathepsins (CTSs) mediate the antigen transmission and inflammatory response involved in the atherosclerosis process, but the specific signal pathways and target cells of the CTSs involved in atherosclerosis are unknown.

Methods
We used the GEO query package to download the dataset GSE28829 from the Gene Expression Omnibus (GEO) and filtered the data to check the standardization of the samples through the box chart. We then used the ‘limma’ package to analyze between-group differences and selected the corresponding differentially expressed genes of CTSs from the protein-protein interaction (PPI) network constructed with the STRING database, and then visualized the CTS-target genes. The best matching pathway and target cells were verified by a male mouse ligation experiment, single-sample GSEA (ssGSEA) analysis, and vitro experiment.

Results
There were 275 differentially expressed genes (DEGs) selected from the GSE28829 dataset, and the DEGs were identified mainly in the PPI network; 58 core genes (APOE, CD74, CP, AIF1, etc.) target three selected CTS family members (CTSS, CTSB, and CTSC). After the enriched analysis, 15 CTS-target genes were markedly enriched in the phagosome signaling pathway. The mouse experiment results revealed that the percentages and numbers of monocytes and neutrophils and the number of CD68+ cells in CTSS deficiency (CatS−/−) group were lower than those in the wildtype (CatS+/+) group. CTSS mediating phagosome via macrophage were further verified by ssGSEA analysis and vitro experiment.

Conclusions
CTSS are the main target molecules in the CTS family that are involved in atherosclerosis. The molecule participate in the progression of atherosclerosis by mediating the phagosome via macrophage.
Comparative Evaluation of the Effects of Lighting Conditions on the Shade Selection of Ceramics using Visual Method
Authors: Kawade Rewa , Kambala Seema Sathe 
Published: February 2022

Background: Tooth shade selection in prosthodontic restorations largely affects the patient satisfaction. Natural daylight is considered as the most recommended and standard source for shade selection. However, due to its inconsistency, shade matching lights have been introduced as an attempt to standardize the effect of light source.
Objectives: Comparative evaluation of the effects of daylight, shade matching light and dental operating light against the grey background on visual shade matching of natural teeth with VITA Classic shade guide. Daylight will be taken as the control group.
Methodology: Shade matching will be conducted in a well illuminated area with grey background. A group of 5 observers with superior color discrimination competence as determined by Pseudo Isochromatic colour test will be chosen for teeth shade matching. The matching will be carried out for 125 subjects under the three lighting conditions. The visual assessment will be done by matching the shade of maxillary central incisor of the subject with VITA Classic shade guide. Comparison will be done for two lighting conditions, each observer will perform this test three times that is for grey background in daylight, shade matching light and dental operatory light.
Expected Results: This study will determine the lighting condition that could be used as a possible alternative of daylight.
Conclusion: It will depict the lighting conditions that will best help the clinician to select the shade that will enhance the esthetics of the prosthesis and restorations.
Detection of 11 Multidrug Resistance Genes among the Strains of A. Baumannii by Computational Approach
Authors: Noufal Z. Mohamed , Girija A. S. Smiline , Ganesh P. Sankar , Priyadharshini J. Vijayashree 
Published: February 2022

Background: Acinetobacter baumannii is typically short, rod shaped gram negative bacterium. The World Health Organisation has declared it as an opportunistic pathogen in humans. Multi drug resistance involves different genetic determinants making the pathogen difficult to treat. So this study is undertaken to characterize the 11 different drug resistant genes from 19 virulent strains of A. baumannii using in-silico PCR.
Aim: Detect the 11 multidrug resistance genes among strains of A. baumannii by computational approach.
Materials & Methods: 11 multidrug resistance genes of A. baumannii were selected. Forward and reverse primers of the 11 genes as reported from earlier studies were used for in-silico PCR amplification. 19 strains of A .baumannii set as default strains on the server were chosen and the amplicon bands were observed.
Result: Among the 11 multidrug resistance genes only blaOXA-51like and blaADC were detected among the 19 virulent strains of A. bauamannii.
Conclusion: The findings of the study documents the frequency of blaADC and blaOXA-51 like from the selected strains of A. baumannii. However further experimental validation must be done towards the periodical surveillance on the drug resistant strains of A. baumannii in hospital settings.
Multiorgan Involvement in COVID-19 Patients: A Review
Authors: Shrivastava Nimisha , Tivaskar Suhas , Luharia Anurag , Christian Ravi 
Published: February 2022

Summary: The episode of severe intense respiratory disorder coronavirus 2 (Sars-CoV2) in December 2019 frame Wuhan, China, leads to widespread coronavirus illness 2019 (COVID-19). Whereas the common cold indications are watched in mellow cases, COVID-19 goes with multiorgan disappointment in extreme patients. The association of different organs in severe patients results from protracting the hospitalization item and expanding the immortality irate. In this survey, we were appointed to investigate the association of other organs in COVID-19 patients, especially in extreme cases. Too, we attempted to define the potential underlying components of SARS-CoV2 actuated multiorgan disappointment. The multiorgan brokenness is characterized by acute lung disappointment, intense liver disappointment, intense kidney harm, cardiovascular disorder, and as well as in a wide range of hematological abnormalities and neurological clutters. The main imperative components are related to the coordinate and circuitous pathogenic features of SARS-CoV2.
Conclusion: Understanding the clinical, research facility, and radiological highlights of COVID-19 in fundamentally unwell patients with multi-organ failure should be clarified for the clinician. As a result, extending the information on the pathophysiology of SARS-COV2-induced multi-organ disappointment may result in way better methods to treat COVID-19-patients and diminish the related dismalness and mortality.
A Study on Reducing the Discharge Turnaround Time of IPD Patients at AVBRH
Authors: Chaudhari Pratiksha Suresh , Shinde Vitthal , Gudhe Vandana 
Published: February 2022

Background: Smooth and patient-friendly admission and discharge processes attract a good number of patients and improve hospital turnover, ultimately bringing good profits to hospitals within optimum use of resources. Delay in the discharge process causes stagnation of patients, ultimately affecting new admissions. Discharge procedures for some critical patients are complicated and challenging. A lot of time is spent on discharge intimation, billing, Pharmacy Clearance, handover, etc. This study aims to assess the discharge process causes of delay in discharge and reflect on ways to improve the efficiency of the discharge process so that the discharge turnaround period can be reduced.
Methodology: This will be a Retrospective Observational study conducted in AVBRH, Wardha. Data will be collected from 60 discharged patients admitted to IPD wards. Data will be collected using a structured questionnaire during personal interviews. Data will be analyzed using appropriate statistical tools.
Expected Results: Some administrative and management gaps and handover gaps are expected to be found, which can be corrected to increase the efficiency of the discharge process.
Conclusion: This Will be drawn as per the findings of study.
Comparative Evaluation of Remineralization Potential of Acidulated Phosphate Fluoride and Hydroxyapatite Nanoparticles with and without Iontophoresis on the Incipient Carious Lesion in Permanent Teeth
Authors: Ragit Rutuja , Rathi Nilesh , Thosar Nilima , Khubchandani Monika 
Published: February 2022

Background: A non- invasive method used to improve the drug delivery with the help of electric arena is termed as Iontophoresis. The iontophoresis process may cause deeper penetration of ions using electric current. Remineralizing nanomaterial may be infused at higher concentrations in the deeper layer of incipient caries under the influence of iontophoresis. Hydroxyapatite crystals are the most stable form of calcium phosphate which is responsible for the mechanical strength of the dental tissues. Improvedre-mineralization occurs more with the apatite particle size of less than 4 µm. Due to the size of the nanocomplexes ofhydroxyapatite, there can be possibilities that they would enter the porosities and diffuse into the body of the subsurface lesion to enhance remineralization using iontophoresis technique.
Objectives: 1) To evaluate the remineralization potential of APF gel with or without iontophoresis on the incipient carious lesion in permanent teeth. 2) To evaluate the remineralization potential of hydroxyapatite nanoparticles with or without iontophoresis on the incipient carious lesion of permanent teeth. 3) To compare the remineralization potential of APF gel and hydroxyapatite nanoparticles with or without iontophoresis on the incipient carious lesion in permanent teeth.
Methodology: Forty extracted intact teeth will be taken and artificial caries will be induced. These specimens will be randomly divided into five groups as per the treatment - 1) APF gel application 2) APF gel with iontophoresis 3) Hydroxyapatite nanoparticles solution application 4) Hydroxyapatite nanoparticles solution with iontophoresis 5) Distilled water (control group). Remineralization will be analysis by using Vickers hardness test. The alterations in the carious lesion will be assessed by confocal laser scanning microscopy.
Expected Results: APF gel and hydroxyapatite nanoparticles with iontophoresis will give superior remineralization effect as compared to the conventional method.
Conclusion: The utilization of the iontophoresis with hydroxyapatite nanoparticle will provide improved mineralization of incipient caries and prove to be a better method for treatment.
Knowledge, Awareness and Practice of Periodontal Therapy during Pregnancy among Dental Professionals
Authors: Santhanam P. , Jeevitha M. , Jayaraman Selvaraj , Kumar M. Naveen 
Published: February 2022

Aim: To assess the knowledge, awareness and practice of periodontal therapy during pregnancy among dental professionals
Materials and Methods: This cross-sectional study was conducted among 100 dental professionals in and around Chennai. A well-structured questionnaire consisted of 18 questions which were used to assess the awareness of periodontal therapy during pregnancy among dental professionals. Simple randomised sampling method was used to categories the sample population (online survey participants).The knowledge, awareness, scores were calculated for the correct answers to the questions. Based on their response data were statistically analysed.
Results: Based on statistical analysis results were tabulated. Around 74% of participants were undergraduates and 26% were postgraduates. Around 64% of the participants were aware of adverse pregnancy outcomes associated with periodontal disease. 80% of the participants were aware that pregnant patients must be turned to the left side on a dental chair for any dental examination and treatment.
Conclusion: The results of the present study showed that knowledge and awareness of periodontal therapy during pregnancy among dental professionals are appreciable among postgraduates than undergraduates. The attitude of the dental professionals, particularly undergraduates toward bringing the facts into clinical practice needs to be improved through integrated programs which can provide better and safe treatment to pregnant patients.
Clinical significance of quantitative blood cultures in newborn infants
Authors: Sabui T , Tudehope DI , Tilse M 
Published: July 2002

Aim: To evaluate quantitative blood culture as a secondary test on a positive blood culture for the diagnosis of sepsis in newborn infants.Method: A 15‐month prospective study of colony forming units (CFU) on positive blood cultures from newborn infants clinically suspected of having bacterial sepsis. Growth of bacteria in peripheral blood cultures was quantified using the isolater 1.5 microbial tube lysis direct plating culture system. Colony forming units were evaluated against a clinical assessment of infection.Results: Of 137 positive blood cultures, 71 (51.8%) were taken from neonates with clinically defined infection and 66 (48.2%) were from non‐infected infants. The clinical and biographical data in these two groups were similar. Coagulase negative staphylococci were the most commonly isolated organisms in each group (60.6%vs 93.9%). Eight deaths from sepsis occurred in the clinically infected group. Eighty‐five per cent of sepsis was late onset. Although a CFU count ≥ 30/mL predicted sepsis (sensitivity 83%, specificity 60%, positive predictive value 69%, negative predictive value 76%), a CFU count < 30/mL did not rule out serious sepsis. The higher the CFU count the greater the likelihood of sepsis.Conclusion: Quantitative blood culture was not shown to be a sensitive secondary test on a positive blood culture to distinguish clinical sepsis from culture contamination. Although a positive threshold of ≥ 30 CFU/mL proved to be optimal, improvement in test performance would be expected with a lower incidence of culture contamination.
Modification of GaAs/AlGaAs growth-interrupted interfaces through changes in ambient conditions during growth
Authors: Kopf R. F. , Schubert E. F. , Harris T. D. , Becker R. S. , Gilmer G. H. 
Published: July 2002

The effect of the ambient conditions in the growth chamber of the molecular beam epitaxy machine during the growth of GaAs/Al0.35Ga0.65As structures was investigated. Both growth-interrupted (120 s at each heterointerface) and uninterrupted surfaces and interfaces were evaluated using a growth temperature of 580 °C. Two ambient conditions were studied: (a) ∼1×10−10 Torr O2; and (b) ultrahigh vacuum (UHV, ∼5×10−11 Torr, with no intentional introduction of contaminants). A striking difference was observed in both the 1.7 K photoluminescence (PL) spectra of single quantum well (SQW) structures and UHV scanning tunneling microscopy (STM) of surfaces, which were grown under ambient condition (a) as opposed to (b). When consecutive growth-interrupted SQW samples were grown with different well widths (25 and 28 Å) under condition (a), the emission energy splitting into several peaks was observed, indicating discrete thicknesses of the well. However, the peak energies shifted as the laser spot was scanned across each sample. Additionally, the peak energy shifted from sample to sample for the same nominal well width.
On the other hand, when SQW samples were grown under condition (b), no variation in the emission energy was observed as the laser was scanned across the sample, or from sample to sample for a given well width. Furthermore, the PL observations are supported by UHV-STM results. UHV-STM images indicated a very rough surface with large islands containing small terraces on top (a bimodal distribution) for condition (a). Conversely, when samples were grown under condition (b), only large islands were observed. For growth interrupted GaAs surfaces, 400 Å×600 Å islands were observed, and for Al0.35Ga0.65As, they were 150 Å×400 Å, with a one-monolayer step in between islands. These data are consistent with abrupt interfaces with only a single-mode distribution for growth-interrupted surfaces. On the other hand, UHV-STM images of uninterrupted GaAs surfaces grown under condition (b) showed islands that were 40–60 Å across. Photoluminesce spectra of a similarly grown SQW sample showed only a single broad emission line, consistent with an interface configuration of many steps which are smaller than the exciton diameter. The results show that interface roughness is sensitive to background O2.