bluuebunny/crossref_metadata_2025_split huggingface dataset:
P-511 Measuring patient-centredness in publicly funded fertility care and private funded fertility care in China
Authors: Liang J , Ma Y , Li Q , Xu W , Jie Q 
Published: June 2022

Abstract

Study question
Does the Patient-Centred Questionnaire-Infertility (PCQ-Infertility) validate in China? Do patients experience different on patient-centredness in public fertility care compared to that in private fertility care?

Summary answer
PCQ-Infertility is valid in China. The patients in private fertility care have better experiences on patient-centredness than that in publicly fertility from results of PCQ-Infertility.

What is known already
Patient-centredness is one of the most important elements of quality of care. The PCQ-Infertility has validated to be a reliable tool to assess the extent of patient-centredness of fertility care in many countries, cross European counties to New Zealand. In China, physicians in many hospitals have recognized the importance of patient-centred infertility care, but lack of using instrument to measure it and then to improve it.

Study design, size, duration
This is a cross-sectional study. A survey with written questionnaire was performed among patients who diagnosed with infertility in Reproductive Medical Center of the First Affiliated Hospital of Hainan Medical University (publicly funded fertility care and Reproductive Medical Center of Hainan Modern Women and Children’s Hospital (private funded fertility care) between July and December 2021.

Participants/materials, setting, methods
In this study, 315 patients and 189 patients completed the survey at two reproductive medical centers. We used patient’s questionnaires to collect data on the patients’ experience with the quality of care. The PCQ-Infertility content, besides background questions, the questionnaire included 46 care aspects. Psychometric tests included inter-item and reliability analyses. An elaborate multivariate multilevel regression analysis was performed to assess the PCQs ability to measure differences in patient-centredness between reproductive medical centers.

Main results and the role of chance
The questionnaire was completed by 315 and 189 patients from the two hospitals. Patients’ mean scores on overall patient-centredness and the eight subscales (possible range 0–3) were calculated. High scores represent positive experiences with care. Both private and public hospitals scored high on care organization and communication. The lowest scores for both hospitals were the subscale, namely,‘information’. The significant differences between two hospitals were in “accessibility, respect for patient’s values, continuity and transition”.

Limitations, reasons for caution
This study is cross-sectional, the sample size is small, and enrolled fertility care centers are only two.

Wider implications of the findings
The PCQ-infertility is encouraged to be used in China to measure the patient-centredness, and can be adopted for quality improvement especially for publicly funded fertility care.

Trial registration number
ChiCTR2100053616
P-577 A Therapeutic Protocol in Previous Failed ART Patients With High Total NK Cells: An RCT
Authors: Saad A.S , Abdelaziz K 
Published: June 2022

Abstract

Study question
To evaluate a combined therapeutic protocol of lipid emulsion, prednisolone & LMWH in cases of failed ART cycles with high NK cells

Summary answer
The combined therapy of lipid emulsion, prednisolone & LMWH had a higher pregnancy rate but not significant than the standard therapy alone.

What is known already
Many researchers have proved that a high numbers and/or cytotoxicity of peripheral blood NK cells is associated with infertility, recurrent spontaneous miscarriage (RSM) and failed ART cycles.
Many investigations have shown that intralipid has the ability to suppress NK cell activity. It is well known that parenteral fat emulsions accumulate in macrophages modifying many immune responses. So, modifying the T helper1/ T helper 2 balance in favor of T helper 2 with implantation chances increase.
Prednisolone has an immunosuppressive and anti-inflammatory actions and has widely used in autoimmune diseases. Prednisolone also reduces the high numbers of uNK in RSM.

Study design, size, duration
This was a prospective randomized controlled trial in 100 cases with failed ART cycles & high NK cells. From Jan 2019- Dec 2021

Participants/materials, setting, methods
One hundred failed ART cases with high NK cells were divided into 2 groups: (Control group)(50 cases) with previous failed ART cycles will undergo standard treatment (progesterone, low dose aspirin & folic a.). While the other (Interventional group)(50 cases) will have in addition to the previous protocol: lipid emulsion begin in the cycle before embryo transfer & prednisolone begin with the start of lipid emulsion & LMWH begin with the day of ET

Main results and the role of chance
Chemical pregnancy was higher in the interventional group (54.0%) than the control group (40.0%) but without statistical significance (P = 0.161). Also, ongoing pregnancy was higher in the interventional group (85.0%) than the control group (60.0%) but without statistical significance (P = 0.094). No significant difference was reported regarding clinical pregnancy (P = 0.943).

Limitations, reasons for caution

Wider implications of the findings
Our results suggest a hopeful therapeutic protocol that may be used in such failed ART cases especially when no other reason can be found. But selecting which cases will benefit the most will need much further investigations.

Trial registration number
NCT03792997
P-597 The effects of triple trigger on IVF outcomes and pregnancy rates in poor responder patients
Authors: Öner G , Yavuz A 
Published: June 2022

Abstract

Study question
Are there any positive effects of triple trigger on oocyte morphology, embryo quality and pregnancy rates in poor responder (POR) patients?

Summary answer
The trigger with human chorionic gonadotropin (hCG), gonadotropin-releasing hormone agonist (GnRHa) and human menopausal gonadotropin (hMG) may improve embryo quality and pregnancy rates in POR.

What is known already
The ESHRE consensus criteria define a poor ovarian response (POR) as less than four oocytes retrieved. Advanced female age and severe sperm disorder were associated fertilization failure after intracytoplasmic sperm injection (ICSI). Also, oocyte quality is pivotal to determine the fertilization of the oocyte. Hence there is no study to evaluate triple trigger on the embryo quality in POR and severe male infertility are excluded.

Study design, size, duration
In this prospective randomized study, we analyzed poor responder patients that have history of fertilization failure and cleavage arrest embryo, including 100 patients with only hCG trigger (group 1), 100 patients with dual trigger hCG + GnRHa (Group 2), and 100 patients with triple trigger hCG + GnRHa + hMG (Group 3). Patients who have the POR criteria according to MII oocytes lower than 4 were included in the analysis.

Participants/materials, setting, methods
Mean age, body mass index (BMI), AMH levels, day-2 FSH and E2, duration of infertility, LH and E2 levels on trigger day, duration of stimulation, total dose of gonadotropins used, number of previous trials, MII oocytes were examined and compared between the groups. Sperm concentration under 5 x 106 mL was not included to exclude severe male factor. Embryo quality, pregnancy rates evaluation was performed for each patient that has been performed GnRH antagonist protocols.

Main results and the role of chance
Age, Body Mass Index (BMI), AMH levels, day 2 FSH and E2, duration of infertility, duration of stimulation, E2 levels on trigger day, and total dose of gonadotropins usage between the three groups were similar. Number of MII oocytes, fertilization (2PN), and D5 (blastocyst) embryo transfer were significantly higher in Group 3 (Table 1). Pregnancy rates are higher in group 3 however significantly not significant.

Limitations, reasons for caution
The study is limited by its sample size and a higher sample size might be used in the future studies to corroborate the current findings. hMG trigger dosage may be arranged in another study.

Wider implications of the findings
Our results showed that the number of MII oocytes 2PN levels, D5 ET were higher in DOR patients triggered with hCG + GnRHa + hMG.

Trial registration number
28012022
P-676 Comparison of hCG triggering versus hCG in combination with a GnRH agonist: a prospective randomized controlled trial
Authors: Yang L , Luo K , Lu G , Lin G , Gong F 
Published: June 2022

Abstract

Study question
Does co-administration of GnRH agonist and Human chorionic gonadotropin(dual trigger) in PGT cycles improve the number of usable blastocysts per patient compared to hCG alone?

Summary answer
Using the dual trigger has no effect on the number of usable blastocysts undergoing the GnRH-ant protocol for PGT compared to triggering with hCG alone.

What is known already
HCG is used at the end of controlled ovarian hyperstimulation as a surrogate LH surge to induce final oocyte maturation. Recently, based on retrospective studies, the co-administration of GnRH agonist and hCG for final oocyte maturation (dual trigger) has been suggested to improve IVF outcome and pregnancy rates.

Study design, size, duration
A prospective, randomized, open-label controlled clinical trial (ChiCTR-ICR-2000031342), enrolled patients attending our university affiliated Infertility and IVF center (the Reproductive and Genetic Hospital of CITIC-Xiangya, China) between August 2020 and June 2021. This sample size achieves with a power of 80%, at a significance level(α) of 0.05. A sample size of 160 patients, 80 randomized to each group, was chosen to allow for those 10% dropped out.

Participants/materials, setting, methods
The inclusion criteria for participating were: women age 20–35years, AMH≥1.2ng/ml and /or AFC ≥5, Couples with PGT-SR preimplantation genetic testing for chromosomal structural rearrangements (patients with abnormal chromosomal structure only in male or female), undergoing one of their first PGT cycle attempts. Patients fulfilled the criteria on the trigger day were randomly assigned to receive hCG or the dual trigger for final oocyte maturation. The primary outcome was the number of usable blastocysts per patient.

Main results and the role of chance
160 patients were included in the study. The age (29.1 years versus 29.4 years), BMI (22.1 kg/m2 versus 21.9 kg/m2) and the AMH (5.3 ng/ml versus 5.3 ng/ml) were comparable between the two groups. Based on PP analysis, there were no statistical difference in the number of eggs retrieved (17.1 versus 15.9), the MII oocytes (13.3 versus 12.5), the number of usable blastocysts per patient (5.0 versus 4.6) and top-quality blastocysts per patient (3.4 versus 3.2) between the two groups.

Limitations, reasons for caution
None

Wider implications of the findings
The enhanced response observed with the dual trigger might lead to better IVF outcomes were it used more widely.

Trial registration number
ChiCTR-ICR-2000031342
P-730 Transparency and Trustworthiness in Randomised Controlled Trials in In Vitro Fertilisation: An Analysis of Published Literature
Authors: Bai Y 
Published: June 2022

Abstract

Study question
What is the transparency and trustworthiness of randomised controlled trials (RCTs) on in vitro fertilisation (IVF) in the past decade?

Summary answer
Quality of IVF-research has improved in the last decade. Further progress can be made by prospective RCT-registration, raw data accessibility and better outlined recruitment timelines.

What is known already
Transparency and trustworthiness are fundamental features in science, and especially in RCTs as these studies provide evidence that guides clinical practice. The number of published RCTs is increasing. The differing quality of the RCTs, however, remains a challenge. A recent study analysing the transparency and reproducibility of RCTs published in high impact journals from 2013 to 2018 has identified trial registration, protocol availability, data accessibility as avenues of improvement (Kemper, 2020). Ongoing optimisation of routine research practices will increase faith in the generated evidence and maximise its potential benefits to the community.

Study design, size, duration
We performed a meta-epidemiologic study with a two-author system. We searched for all RCTs evaluating IVF published from 01/01/2010 to 23/08/2021 inclusive. Included studies were scored on transparency and trustworthiness. The main parameters were trial registration, protocol publication, funding and

Trial registration number
Not applicable
A Guide for Successful Research Collaborations between Zoos and Universities
Authors: Schulz Andrew K , Shriver Cassie , Aubuchon Catie , Weigel Emily G , Kolar Michelle , Mendelson III Joseph R , Hu David L 
Published: June 2022

SynopsisZoos offer university researchers unique opportunities to study animals that would be difficult or impractical to work with in the wild. However, the different cultures, goals, and priorities of zoos and universities can be a source of conflict. How can researchers build mutually beneficial collaborations with their local zoo? In this article, we present the results of a survey of 117 personnel from 59 zoos around the United States, where we highlight best practices spanning all phases of collaboration, from planning to working alongside the zoo and maintaining contact afterward. Collaborations were hindered if university personnel did not appreciate the zoo staff’s time constraints as well as the differences between zoo animals and laboratory animals. We include a vision for how to improve zoo collaborations, along with a history of our own decade-long collaborations with Zoo Atlanta. A central theme is the long-term establishment of trust between institutions.
Strategic 2-step surgery using thoracic endovascular aortic repair for an infected thoracic aortic aneurysm
Authors: Nakano Mitsunori , Miyagawa Atsushi , Shinoda Daigo , Yuri Koichi 
Published: June 2022

Abstract
An 81-year-old man with multiple comorbidities developed infected thoracic aortic aneurysm, and we employed a strategic 2-step surgical approach combining thoracic endovascular aortic repair and local debridement with an omental flap during the active phase of infection. No signs of reinfection were observed at the 1-year follow-up. This strategy can be a safe and less invasive alternative to conventional open surgery in patients with high surgical risk.
Interplay between demographic, clinical and polygenic risk factors for severe COVID-19
Authors: Crossfield Samantha S R , Chaddock Natalie J M , Iles Mark M , Pujades-Rodriguez Mar , Morgan Ann W 
Published: June 2022

AbstractBackgroundWe aimed to identify clinical, socio-demographic and genetic risk factors for severe COVID-19 (hospitalization, critical care admission or death) in the general population.MethodsIn this observational study, we identified 9560 UK Biobank participants diagnosed with COVID-19 during 2020. A polygenic risk score (PRS) for severe COVID-19 was derived and optimized using publicly available European and trans-ethnic COVID-19 genome-wide summary statistics. We estimated the risk of hospital or critical care admission within 28 days or death within 100 days following COVID-19 diagnosis, and assessed associations with socio-demographic factors, immunosuppressant use and morbidities reported at UK Biobank enrolment (2006–2010) and the PRS. To improve biological understanding, pathway analysis was performed using genetic variants comprising the PRS.ResultsWe included 9560 patients followed for a median of 61 (interquartile range = 34–88) days since COVID-19 diagnosis. The risk of severe COVID-19 increased with age and obesity, and was higher in men, current smokers, those living in socio-economically deprived areas, those with historic immunosuppressant use and individuals with morbidities and higher co-morbidity count. An optimized PRS, enriched for single-nucleotide polymorphisms in multiple immune-related pathways, including the ‘oligoadenylate synthetase antiviral response’ and ‘interleukin-10 signalling’ pathways, was associated with severe COVID-19 (adjusted odds ratio 1.32, 95% CI 1.11–1.58 for the highest compared with the lowest PRS quintile).ConclusionThis study conducted in the pre-SARS-CoV-2-vaccination era, emphasizes the novel insights to be gained from using genetic data alongside commonly considered clinical and socio-demographic factors to develop greater biological understanding of severe COVID-19 outcomes.
Patient satisfaction with inpatient pharmacy services at tertiary care setting—a meta-analysis of recent literature
Authors: Azhar Anam , Wasif Gillani Syed , Jiaan Nada , Menon Vineetha , Abdi Semira , Rathore Hassaan A 
Published: June 2022

AbstractObjectivesThis study aimed to determine patient satisfaction with the following pharmacist-led services for inpatients in tertiary care hospitals.MethodsStudies were identified from different databases from 2012 to 2020. A total of 1910 articles were identified using the search strategies out of which 1153 were rejected based on the review of titles and abstracts. The search criteria were the roles of inpatient pharmacists and patient satisfaction with inpatient pharmacy services. Multiple keywords were used such as ‘patient satisfaction’/‘inpatient pharmacist’/‘pharmacist hospital services’/‘clinical pharmacist roles’. The quality of each study was measured using the mixed methods appraisal tool, and the same was used to evaluate the risk of bias as well.Key findingsA total of 11 cross-sectional studies were included in the evidence synthesis of this meta-analysis. Three studies tested the satisfaction of patients with inpatient counselling with a sample size of n = 742. The odd ratio (OR) was 215.33 (141.77 to 327.05) [95% confidence interval (CI)] showed a significant patient satisfaction (P = 0.00001) with the pharmacist’s inpatient counselling (I2 = 0%). Studies showed a statistically significant satisfaction of patients with discharge counselling P &lt; 0.00001 and OR 55.74 (35.93 to 86.49) and heterogeneity I2 = 0%. In a total of five studies, the healthcare professional (HCP) satisfaction with pharmacist services was reported, and satisfied and unsatisfied HCPs were n = 801 and n = 362, respectively. Results showed high satisfaction (P &lt; 0.00001) and OR 4.62 (95% CI, 3.89 to 5.48).ConclusionThis meta-analysis concluded that clinical pharmacist services in an inpatient setting have a significant impact on increasing patient satisfaction with their treatment. The clinical pharmacist services are not very well implemented and are limited in some hospitals, but patients who have received these services were highly satisfied and expected to receive them more often.
Vienna—The Cradle of Sephardic Sephardism
Authors: Stechauner Martin 
Published: June 2022

Abstract
This article explores the rise and development of ‘Sephardism’ among Sephardic Jews in Vienna. Sephardism was originally a cultural phenomenon among the Ashkenazic Jews of Germany and Austria in the early nineteenth century. Based on the ‘Myth of Sephardic Supremacy’, they used it as a paradoxical emancipatory attempt to simultaneously stand out and integrate within the non-Jewish majority culture. Sephardic intellectuals in Vienna, living in a predominantly liberal Ashkenazic milieu, turned out to be highly receptive to some of the variants that German-Jewish Sephardism had to offer. Thus, during the second half of the nineteenth century, the Viennese Sephardim developed their own ‘Sephardic Sephardism’ with the aim of celebrating their own Sephardic (i.e. ‘Spanish’) heritage within a predominantly Ashkenazic environment. In the process, Sephardic Sephardism redefined the Viennese Sephardim’s self-image as Sephardic Jews, especially within the Eastern Sephardic Diaspora, where most Jews previously had little to no awareness of their Spanish origin.
Digital transit ports for the illicit trade in antiquities: the case of the ‘Afghan Genizah’
Authors: Palombo Cecilia , Yates Donna 
Published: June 2022

AbstractIn this article, we present the idea of a digital transit port, an online space that illicit cultural objects pass through in digital format while on a pathway to public legitimization. These virtual transit ports connect virtual illicit and illegally trafficked cultural objects with virtual consumers under the aegis of promoting access and preservation, while simultaneously normalizing the presence of these objects in market and academic spaces. Digital transit ports, then, make virtual versions of illicit cultural objects openly consumable, much like physical transit ports launder physical cultural objects. They may also legitimize use of the physical objects, infringing on legislative efforts at curbing the illicit trade. To explore the idea of the digital transit port, we will consider the case of the so-called ‘Afghan Genizah’ collection, a disarticulated group of historical documents from northern Afghanistan that have appeared on the international market most likely after being looted and trafficked illicitly outside their country of origin.
Quantum study of the bending relaxation of H2O by collision with H
Authors: Cabrera-González Lisán David , Denis-Alpizar Otoniel , Páez-Hernández Dayán , Stoecklin Thierry 
Published: June 2022

ABSTRACT
Vibrationally excited levels of the H2O molecule are currently detected in various environments of the interstellar medium (ISM), and collisional data for H2O, including vibration with the main colliders of the ISM, are needed. The present study focuses on the bending relaxation of H2O by collision with H when taking bending–rotation coupling explicitly into account with the rigid-bender close-coupling (RB-CC) method. With this aim, a new four-dimensional potential energy surface including the H2O bending mode is developed from a large grid of ab initio energies computed using a high level of theory. For purely rotational transitions, our RB-CC rates show very good agreement with rigid-rotor calculations performed using our new potential energy surface (PES) and with those available in the literature. Calculations for pure rotational transitions inside the excited bending level ν2 = 1 of H2O are performed and compared with their equivalents inside ν2 = 0. Vibrational quenching of H2O is also calculated and found to be much more efficient through collision with H rather than with He.
On cosmological bias due to the magnification of shear and position samples in modern weak lensing analyses
Authors: Duncan Christopher A J , Harnois-Déraps Joachim , Miller Lance , Langedijk Alexander 
Published: June 2022

ABSTRACT
The magnification of galaxies in modern galaxy surveys induces additional correlations in the cosmic shear, galaxy–galaxy lensing, and clustering observables used in modern lensing ‘3 × 2 pt’ analyses, due to sample selection. In this paper, we emulate the magnification contribution to all three observables utilizing the SLICS simulations suite, and test the sensitivity of the cosmological model, galaxy bias, and redshift distribution calibration to un-modelled magnification in a Stage-IV-like survey using Monte Carlo sampling. We find that magnification cannot be ignored in any single or combined observable, with magnification inducing &gt;1σ biases in the w0−σ8 plane, including for cosmic shear and 3 × 2 pt analyses. Significant cosmological biases exist in the 3 × 2 pt and cosmic shear from magnification of the shear sample alone. We show that magnification induces significant biases in the mean of the redshift distribution where a position sample is analysed, which may potentially be used to identify contamination by magnification.