bluuebunny/crossref_metadata_2025_split huggingface dataset:
In‐silico calibration of intracranial aneurysm thrombosis models based on clinical data
Authors: Liu Qiongyao , Foroushani Ali Sarrami , Wang Yongxing , Macraild Michael , Kelly Christopher , Ravikumar Nishant , Taylor Zeike A. , Patankar Tufail , Lassila Toni , Frangi Alejandro F. 
Published: May 2022

Abstract
How common is spontaneous thrombosis (ST) formation in intracranial aneurysms (IAs); and how ST differs in normo- and hypertensive conditions? We address the former question by a thorough analysis of published datasets to identify the incidence of ST across different patients and demographics. Based on the statistical ST incidence in large and giant (LG) aneurysms (>10 mm), we perform an in-silico observational study in 89 virtual patients to calibrate two trigger thresholds, residence time (RT) and shear rate (SR). We then address the second question by using a calibrated thrombosis model to study the effects of hypertension on thrombus formation. According to our statistical analysis, the clinical ST (partial or complete) incidence for LG IAs is 40.67% (85/290) ±5.59%, with 90% confidence. The accuracy of our calibrated model in predicting ST is 75.8% by comparison with 62 documented clinical cases. Our model predicts a lower ST incidence in hypertensive patients due to the smaller maximum RT in the aneurysm sac caused by hypertension. This study not only collates ST literature and improves our clotting model by providing more accurate threshold parameters, but also reveals that ST may be less common in hypertensive patients.
Gully erosion susceptibility assessment using machine learning techniques, Shazand watershed, Iran
Authors: Mohammady Majid , Davudirad Aliakbar 
Published: May 2022

Abstract
Soil, as a valuable natural resource, provides a large number of services and plays an important role in the environment and world economy. Soil degradation and erosion reduce the quality and quantity the soil and are important natural and anthropogenic processes that affect many countries. Water erosion is the most common type of soil degradation in the world and Asia has about fifty percent of the total water erosion area of the world. Gullies are a typical erosion type and gully formation is an important process of soil erosion and degradation in semi-arid and arid areas, especially areas impacted by human activities and land uses. Because of arid and semi-arid climate, piping and gully erosion is an active phenomenon in the agricultural lands, bare land and rangeland areas of the Shazand watershed, Markazi Province, central Iran. The goal of this research was to identify the priority conditioning factors of gully erosion, map the susceptibility of the Shazand watershed to gully erosion and compare some of the applied machine learning techniques based on their accuracy. Prioritization of conditioning factors using a random forest (RF) algorithm demonstrated that distance from the roads, altitude, and rainfall have the greatest impact on gully occurrence in the Shazand watershed. The RF, boosted regression tree (BRT), functional discriminant analysis (FDA), generalized linear model (GLM), and mixture discriminant analysis (MDA) algorithms were applied to create gully erosion susceptibility maps in the study area. The receiver operating characteristic curve (ROC) and area under the curve (AUC) performance metrics were used to validate susceptibility maps. The AUC values of 0.850, 0.831, 0.760, 0.751, and 0.758 were achieved for the RF, BRT, FDA, GLM, and MDA algorithms, respectively. Due to the negative and destructive effects of gully erosion, its management and control is a critical component in the management of natural resources and land uses. The susceptibility maps of gully erosion prepared in this study are a substantial information resource for decision makers, planners, and engineers concerned with human impacts on natural resources and land uses. The areas identified with high and very high erosion susceptibility in the Shazand watershed need more care to mitigate the consequences of gully erosion and soil degradation.
Development of mungbean (Vigna radiata L. Wilczek) genotypes for shattering tolerance and correlation analysis with biochemical and morphological factors governing Pre harvest sprouting
Authors: Mogali Suma , Patil N. K. Biradar , H Ranjita , Balol Gurupad 
Published: May 2022

Abstract
Development of pre-harvest sprouting (PHS) tolerant varieties is imperative to minimize yield losses due to viviparous germination. F2 seeds derived from the crosses DGGV-2 x Pant Moong-1 were irradiated with 60 kR gamma rays for the creation of desirable variability. In F2M2 generation, segregants with small pod beak and angle, thick pod wall, hard seededness and higher epicuticular wax and lignin content were isolated. Desirable mutants conferring tolerance to PHS were selected from 206 progenies consisting of 4812 plants. During the subsequent selfing generations the desirable plants with less than five percent PHS were stringently characterized by morphological and biochemical indicators. Due to incessant heavy rain fall (462.2mm) during pod development and maturity coupled with high humidity weather was conducive for viviparous germination, resulting in higher PHS. Correlation analysis between pre harvest sprouting and biochemical and morphological parameters revealed that negative correlation of PHS was observed for epicuticular wax (r = -0.983), phenol (r = -0.892), lignin content (r = -0.981) and hard seed percentage (r = -0.942). Significant negative correlation was observed for pod wall thickness (r = -0.570). Pod beak length recorded highly significant positive correlation (r = 0.911) to PHS. Genotypes with inherent tolerance to seed shattering hold a promise to minimize yield losses due to viviparous germination.
Dog domestication strongly relied on translation regulation according to differential gene expression analysis
Authors: Jónás Dávid , Tátrai Kitti , Sándor Sára , Egyed Balázs , Kubinyi Enikő 
Published: May 2022

Abstract
The domestication of dogs from their shared ancestors with wolves occurred around 25,000 years ago and affected many characteristics of the species, including its appearance and behavior. Comparative RNA sequencing experiments can help shed light on the delicate details of gene expression regulation responsible for the variance in complex traits between dogs and wolves. Previously, Yang et al. identified the differentially expressed genes in the blood transcriptome of two Asian dogs and three wolves. We extended this study by adding ten European dog blood RNA-seq samples. The additional European samples made the analyzed dog cohort significantly more heterogenous, helping us avoid the detection of false positives. 40-120 million reads were aligned to the CanFam v3.1 reference genome per sample, ensuring high confidence in our results and conclusions. We detected approximately 14,000 expressed genes in the samples. Analyzing the sequence data, we found that the sample origin (Europe or Asia) had a significant effect on blood gene expression levels. Consequently, this was corrected for in the differential gene expression analysis model. We identified 1,807 differentially expressed genes between the two species and identified several significantly overrepresented gene ontology terms, such as rRNA binding, ribosomal large subunit biogenesis, and translation. Our functional gene ontology analysis implies that gene expression and regulation had a significant role in dog domestication. The findings suggest that further comparative studies between wolves and dogs should rely on a more diverse sample, including individuals from different breeds and geographical origins, to enhance the specificity of detecting differentially expressed transcripts between wolves and dogs.
Targeted analysis of HSP70 isoforms in human spermatozoa in the context of capacitation and motility
Authors: Grassi Sarah , Bisconti Marie , Martinet Baptiste , Arcolia Vanessa , Simon Jean-François , Wattiez Ruddy , Leroy Baptiste , Hennebert Elise 
Published: May 2022

Abstract

HSP70s constitute a family of chaperones, some isoforms of which appear to play a role in sperm function. Notably, global proteomic studies analysing proteins deregulated in asthenozoospermia, a main cause of male infertility characterized by low sperm motility, showed the deregulation of some HSP70 isoforms. However, to date, no clear trend has been established since the variations in the abundance of HSP70 isoforms differed between studies. The HSPA2 isoform has been reported to play a key role for fertilization, but its deregulation and possible relocation during capacitation, a maturation process making the spermatozoon capable to fertilize an oocyte, is debated in the literature. The aim of the present study was to investigate the fate of all sperm HSP70 isoforms during capacitation and in relation to sperm motility. Using Multiple-Reaction Monitoring (MRM) mass spectrometry, we showed that the relative abundance of all detected isoforms was stable between non-capacitated and capacitated spermatozoa. Immunofluorescence using two different antibodies also demonstrated the stability of HSP70 isoform localization during capacitation. We also investigated spermatozoa purified from 20 sperm samples displaying various levels of total and progressive sperm motility. We showed that the abundance of HSP70 isoforms is not correlated to sperm total or progressive motility and does not vary significantly between astheno-teratozoospermic, normozoospermic, and teratozoospermic samples.
Cancer-related correlates of Traditional and Complementary Medicine use among Norwegian cancer survivors: A cross-sectional study
Authors: Nakandi Kiwumulo , Stub Trine , Kristoffersen Agnete Egilsdatter 
Published: May 2022

Abstract
Background
Cancer survivors are a diverse group with varying needs that are patient-, disease-, and/or treatment-specific. Cancer survivors have reported supplementing conventional anti-cancer treatment with Traditional and Complementary Medicine (T&CM) to combat the effects of the disease, as well as the adverse effects of conventional anti-cancer treatments, at different phases of their diagnosis. We aimed to study disease- and treatment-related correlates of T&CM use among Norwegian cancer survivors.
Methods
Data was collected from the seventh survey of the Tromsø Study, Tromsø 7, conducted in 2015-16 among residents of the Tromsø municipality aged 40 and above. Of the 32 591 inhabitants invited, 21 083 accepted the invitation leading to a response rate of 64.7%. The Tromsø study consists of a three-part questionnaire and a thorough clinical examination. In addition to data from the Tromsø study, data on cancer diagnosis and conventional anti-cancer treatment were collected from the Cancer Registry of Norway. Pearson chi-square test, Fisher’s exact tests and independent sample t-test were used to compare T&CM users with non-users. Statistical significance was set at the p-value of < 0.05. All statistical analyses were conducted using Statistical Package for Social Sciences (SPSS) version 28.0 for Windows.
Results
T&CM was used by 31.2% of the participants with natural remedies as the most reported modality of T&CM (18.2%, n = 238), followed by self-help practices of meditation, yoga, qigong, or tai chi, which was reported by 8.7% (n = 114). Provider-based T&CM were reported by 10.0%, where each (acupuncturists; traditional healers; and other CM providers) were reported by 4% of the participants, respectively. Users of T&CM were significantly younger and more likely to be female (p < .001) than the non-users, with higher use of T&CM among females with poor self-reported health, distant metastasis, and being 1–5 years post-diagnosis. Lower use was found among women who received a combination of surgery and hormonal therapy. Similar trends were seen in males, but not at a significant level. For both males and female, T&CM was most frequently used by those with only one cancer diagnosis (p = .046).
Conclusion
The findings suggest that there is a difference in clinical predictors for T&CM between female and male cancer survivors, with more clinical predictors among females.
The instantaneous phase difference between two cables with different parameters under parametric excitation: characteristics and originations
Authors: SUN Ceshi , Lin Junqiang , Deng Zhengke , Jiao Dewang 
Published: May 2022

Abstract
The response phase of a nonlinear vibrating cable under fixed excitation frequency is commonly believed to be a constant value in the linear solution, while the higher-order terms (HOTs) effect is omitted. However, as the variation of cable parameters, the HOTs would have a significant contribution to the response and thus changes the phase instantaneously. In order to ascertain the instantaneous phase difference between cables with the consideration of the HOTs, the instantaneous phase-frequency characteristics of two suspended cables with different parameters are investigated. The dimensionless dynamic equations of a two-cable system were derived, and the discrete ordinary differential equations were obtained using the Galerkin method and then solved by the Method of Multiple Scales (MSM). The MSM solution was verified simultaneously using the Runge-Kutta method (R-K) and the Finite Element Method (FEM). The numerical analysis shows that the HOTs’ influence on the instantaneous phase cannot be ignored in some frequency range. The origination of the instantaneous phase difference between the two cables with different parameters comes from two aspects: (i) the difference in the phase shift values (PSVs) in the linear term; and (ii) the difference in the proportion of the drift terms (DTs) in the HOTs.
Κ-Carrageenan Oligosaccharides Postpone the Progression of Alzheimer's Disease by Inhibiting Neuronal Damage Caused by Microglial Overactivation
Authors: Yao Zi-ang , Xu Ling , Jin Li-ming , Li Jiang-zhou , Wang Tian-sheng , Wang Yong , Lu Rong-hao , Bai Ying , Wu Hai-ge 
Published: May 2022

Abstract
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by gradual decline of cognitive function, which is also one of the main causes of cognitive and memory impairment in the elderly. The delicate balance between the pro-inflammatory and anti-inflammatory properties of microglia determines its role in the occurrence and development of AD. Κ-carrageenan oligosaccharide (KOS) was obtained by enzymatic hydrolysis of carrageenan from Marine red algae, which can inhibit the over activation of microglia. In this study, APP/PS1 transgenic mice were used to study the effect of KOS on the symptoms of AD mice by detecting the ability of learning and memory, the activation of microglia cells, the expression of related proteins in the brain, and the deposition of APP and Aβ1−42. The expression of inflammatory cytokines and inflammation-related proteins in microglia cells were detected in vitro, and the effects of KOS on over activation of microglia cells were determined. In addition, microglia and nerve cells were cultured in transwell co-culture system to study the effect of microglia cells treated with KOS on the activity of nerve cells. The results showed that KOS could inhibit clinical symptoms and inflammatory responses by microglia of AD mice. The apoptosis of nerve cells caused by the inflammatory response of microglia was also decreased. KOS could improve the spatial learning and memory ability of AD mice and inhibit over activation of microglia, which has a promising application in the prevention and treatment of AD.
Studies of synthesis of Zeolite/TiO 2 composite based dye-sensitized solar cell application
Authors: Dandolia Ramkumar Singh , Tomar S. S. , Dandotia Arvind , Tiwari R. K. 
Published: May 2022

Abstract
This paper focuses on the performance of introducing zeolite nanocomposite into photoanodes of dye-sensitized solar cells (DSSCs). Mesoporous titanium dioxide (TiO2) and zeolite nanoparticles were synthesized using the hydrothermal technique. TiO2/ zeolite composites were prepared by sol-gel techniques. The Synthesized nanocomposite was characterized by various techniques like X-ray diffraction technique (XRD), Scanning electron microscopy (SEM), and UV–Vis’s spectrophotometer. XRD analysis showed the highly crystalline zeolite, Titanium oxide and their composite is showing polycrystalline nature. SEM results elucidated that the incorporation of Titanium oxide into the zeolite changed the surface morphology from rectangular to spherical. UV-Vis’s spectroscopy shows that the bandgap of zeolite, titanium oxide, and its composite is 2.96, 3.4, and 3.24 eV, respectively. I-V results confirmed the formation of p-n heterojunction was formed between p– and n-type materials indicating that this is the behavior of solar cell devices.
Parameter estimation and tracking algorithm for resolvable group targets based on GLMB filter and RLS algorithm
Authors: Liu Weifeng , Zhao Zhi , Liu Qiliang , Peng Zhangming 
Published: May 2022

Abstract
The current resolvable group target tracking algorithms can only track a small number of group targets and assume that the standard deviation vectors(SDVs) are known. Based on the RFS framework, this paper first proposes a group target tracking algorithm based on serial GLMB, in order to save the computational cost of filter tracking large-batch and multi-structure group target when the SDVs are known. Then the least squares and the k-means algorithms are used to jointly estimate the SDVs and the group target states. The experimental simulation results verify the effectiveness of the proposed methods.
Bioinformatics screening of biomarkers related to glioma
Authors: Yang Xitong 
Published: May 2022

Abstract
To screen target genes analyze the expression and mechanism of target genes in glioma. Glioma data were downloaded from TCGA database. Differentially expressed genes (DEGs) were screened by differential expression screening, protein-protein interaction (PPI) and enrichment analysis, and then the differentially immune related genes were obtained by analyzing DEGs and immune genes. The abundance of 22 leukocyte subtypes was calculated by CIBERSORT algorithm. The Hub gene constructed by PPI and the gene of prognosis model were analyzed to screen the glioma target gene. The correlation between target gene and glioma prognosis and clinical characteristics of glioma were analyzed. After immunotherapy, the survival of high TMB group was significantly longer than that low TMB group, and the scores of TMB group were correlated with the age of patients. PPI indicates that AURKA, BUB1, AURKB, CDC20, BIRC5, TTK, CCNB2, CDCA8 and CENPE are the hub genes of glioma. The expression level of BIRC5 in glioma tumor tissues was significantly higher than that in normal tissues. BIRC5 might participate in the occurrence and development of glioma through P53 pathway. BIRC5 can be used as glioma target gene, and its high expression in glioma indicates poor prognosis, provides a new direction for immunotherapy of glioma.
Radiation and Convection Heat Transfer Optimization with MHD Analysis of a Hybrid Nanofluid within a Wavy Porous Star-Like Enclosure
Authors: Hosseinzadeh Kh. , Moghaddam M. A. Erfani , Nateghi SeyedKeivan , Shafii Mohammad Behshad , Ganji D. D. 
Published: May 2022

Abstract
Thermal performance maximization is a necessity in various systems that are dealing with any scale of heat flux. This requirement has been intensified due to introduction of more complex and highly crammed products, making heat dissipation a daunting task. Addressing this challenge, a curved porous star-shaped enclosure with a rounded cavity and occupied by hybrid nanoparticles of Fe3O4-Al2O3scattered uniformly in 1-Hexanol has been simulated by Galerkin finite element method. The temperature difference between inner cavity and outer wavy surface stirred the heat flux within the bounded domain. The determinants of thermal evolution are classified by porosity alteration, radiation intensity, magnetic field and natural convection strength in the form of corresponding dimensionless numbers namely epsilon, Rd, Ha and Ra. The streamlines and isotherms contours accompanied by local Nu plots for each parameter are presented. The revealed that external magnetic field deteriorates Nu and by implication convection while higher values of Ra translated to better performance. Regarding the porosity, the best output was recognized at lower porosities, with radiation having no sizeable impact on the Nu and flow field. Due to contradictory influence of the studies factors, an optimization by RSM and Taguchi incorporation led to the detection of optimum Nu and introduction of an expression for average Nu based on the investigated determinants.
Two novel species of Mesophoma gen. nov. from PR China and a potential biocontrol of the invasive weed Ageratina adenophora
Authors: Yang Ai-Ling , Chen Lin , Cheng Lu , Li Jin-Peng , Zeng Zhao-Ying , Zhang Han-Bo 
Published: May 2022

Abstract
During an investigation of the fungal pathogens associated with the invasive weed Ageratina adenophora from China, some interesting isolates were collected. Among them, a novel genus Mesophoma containing two novel species, M. speciosa and M. ageratinae, from healthy leaf, leaf spot, and roots of Ag. adenophora was found. Phylogenetic analysis of the combined the internal transcribed spacer (ITS), large nuclear subunit ribosomal DNA (LSU), the RNA polymerase II second largest subunit (rpb2), and the partial β-tubulin (tub2) sequences showed that M. speciosa and M. ageratinae each formed a distinct clade, separating from all genera previously described in Didymellaceae. Combined morphological characters allowed us to describe them as novel species belonging to a novel genus Mesophoma. The full descriptions, illustrations, and a phylogenetic tree showing the position of M. speciosa and M. ageratinae were provided in this study. The potential for these strains to be developed into a biocontrol for the spread of the invasive weed Ag. adenophora was also discussed.
Integrated analysis of multi-omics data to establish a hypoxia-related prognostic model in osteosarcoma
Authors: Tong Ye , Zhang Xiaoqing , Zhou Ye 
Published: May 2022

Abstract
Objective: Osteosarcoma (OS) is the most common malignant bone tumor in clinical practice, and currently, the ability to predict prognosis in the diagnosis of OS is limited. There is an urgent need to find new diagnostic methods and treatment strategies for OS.Methods: We downloaded the multi-omics data for OS from the TARGET database. Prognosis-associated methylation sites were used to identify clustered subtypes of OS, and OS was classified into three subtypes (C1, C2, C3). Survival analysis showed significant differences between the C3 subtype and the other subtypes. Subsequently, differentially expressed genes (DEGs) across subtypes were screened and subjected to pathway enrichment analysis. Results: A total of 249 DEGs were screened from C3 subtype to other subtypes. Metabolic pathway enrichment analysis showed that DEGs were significantly enriched to the hypoxic pathway. Based on univariate and multivariate COX regression analysis, 12 genes from the hypoxia pathway were further screened and used to construct hypoxia-related prognostic model (HRPM). External validation of the HRPM was performed on the GSE21257 dataset. Finally, differences in survival and immune infiltration between high and low risk score groups were compared. Conclusion: In summary, we proposed a hypoxia-associated risk model based on a 12-gene expression signature, which is potentially valuable for prognostic diagnosis of patients with OS.