bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perovskite‐Socketed Sub‐3 nm Copper for Enhanced CO2 Electroreduction to C2+
Authors: Li Yuxi , Liu Fuzhu , Chen Zitao , Shi Lei , Zhang Zhenbao , Gong Yue , Zhang Yu , Tian Xuezeng , Zhang Yu , Qiu Xiaoyu , Ding Xiangdong , Bai Xuedong , Jiang Heqing , Zhu Yongfa , Zhu Jiawei 
Published: September 2022

AbstractIn situ socketing metal nanoparticles onto perovskite oxides has shown great potential in heterogeneous catalysis, but its employment in boosting ambient CO2 electroreduction (CER) is unexplored. Here, a CER catalyst of perovskite‐socketed sub‐3 nm Cu equipped with strong metal–support interactions (SMSIs) is constructed to promote efficient and stable CO2‐to‐C2+ conversion. For such a catalyst, plentiful sub‐3 nm ellipsoid Cu particles are homogeneously and epitaxially anchored on the perovskite backbones, with concomitant creation of significant SMSIs. These SMSIs are able to not only modulate electronic structure of active Cu and facilitate adsorption/activation of key intermediates, but also to strengthen perovskite–Cu adhesion and intensify resistance to structural degradation. Beneficial from these advantageous merits, when evaluated in CER, it performs comparably to or better than most reported Cu‐based heteronanostructures. Relative to a physical‐mixture counterpart, it features marked improvements (up to 6.2 folds) in activity and selectivity for C2+, together with greatly boosted stability (>80 h). This work gives a new avenue to rationally design more advanced Cu‐based heteronanostructures for CER.
High Hysteresis Suspended Wetting State: A Wetting Regime for Controlled Trapping of Drops on Micro‐Trench Covered Surfaces
Authors: Rajak Anil , Rühe Jürgen 
Published: September 2022

AbstractWetting of simple liquids on rough surfaces is usually described either by the Cassie–Baxter model where drops are suspended over the roughness features with air trapped below, or by the Wenzel model where the drops are impaled on the roughness features. According to the Wenzel model, drops can be trapped on the surfaces, whereas in the Cassie–Baxter model, the drops can be easily released upon adding a small tilt. Surfaces with very regular surface pattern, such as closely spaced micro‐trenches, can exhibit the so‐called High Hysteresis Suspended State (HySS). In this state the drops assume a spherical shape with air trapped below them, a characteristic feature of the Cassie–Baxter state, but show a very high contact angle hysteresis (up to >70°), typical for the Wenzel regime. The HySS regime is studied as a function of the surface geometry, applied pressure and the mass of the drop. Through roll‐off measurements it is shown that surfaces with controlled trapping conditions can be generated, where drops can be captured, however, upon addition of a small amount of energy (e.g., induced by tilt) can be released. The parameters that can be used to control the “depth” of the trap are elucidated.
One‐Step Spraying Fabrication of Superomniphobic Coatings with Anti‐Flame, Anti‐Corrosive, and Mechanochemically Durable Ability
Authors: Bu Xinyu , Zhang Hailong , Sun Chaofan , Ji Xingxiang , Tao Furong , Gai Ligang , Jiang Haihui , Liu Libin 
Published: September 2022

AbstractA durable and high‐quality superomniphobic coating that gives good repellency to water and organic liquid with lower surface tension is critical for basic research and practical applications. Although it has made significant progress, incorporating flame retardancy without sacrificing its superomniphobicity and durability remains a challenge. Here, these challenges are addressed by one‐step spraying suspension consisting of epoxy resin, micro/nano‐particles, and flame retardant. The durability and flame retardancy can be regulated by adjusting the mass ratio of different components and curing temperature. The resulting coating possesses good superomniphobicity (repelling liquids with surface tension as low as 21 mN m−1) and mechanochemical durability even under severe environments such as harsh abrasion, high temperature, erosion of aqua regia, and other strong alkaline substances. In addition, the coating is resistant to metal corrosion and exhibits excellent flame retardance ability. Combined with this convenient spraying process, the coating is more conducive to realizing industrial production.
Responsive Chiral Photonic Cellulose Nanocrystal Materials
Authors: Qu Dan , Rojas Orlando J. , Wei Bing , Zussman Eyal 
Published: September 2022

AbstractResponsive photonic crystals have attracted significant attention in fundamental scientific research and technological applications. Upon applying external stimuli, such as mechanical, electrical, magnetic, and optical triggers, the optical properties of photonic crystals can be actively tuned. Among a large number of photonic crystals, cellulose nanocrystals (CNCs) are considered one of the most promising materials due to their renewability, simplicity of preparation, and unprecedented chirality. A comprehensive overview of the fundamental design principles, methodologies, responsive mechanisms, and practical applications of responsive chiral photonic CNC materials is presented here. The changes in helix pitch, refractive index, orientation, and resulting structural and optical properties of chiral photonic CNCs in response to various stimuli are discussed. Thereafter, novel applications of responsive chiral photonic CNCs, such as colorimetric sensors, photonic actuators, rewritable photonic papers, and anti‐counterfeiting smart tags are described. We conclude by discussing future challenges and opportunities for developing high‐performance responsive chiral photonic CNC materials.
Organic–Inorganic Hybrid Cuprous‐Based Metal Halides for Warm White Light‐Emitting Diodes
Authors: Meng Xuan , Ji Sujun , Wang Qiujie , Wang Xiaochen , Bai Tianxin , Zhang Ruiling , Yang Bin , Li Yimeng , Shao Zhipeng , Jiang Junke , Han Ke‐li , Liu Feng 
Published: September 2022

AbstractSingle‐component emitters with stable and bright warm white‐light emission are highly desirable for high‐efficacy warm white light‐emitting diodes (warm‐WLEDs), however, materials with such luminescence properties are extremely rare. Low­dimensional lead (Pb) halide perovskites can achieve warm white photoluminescence (PL), yet they suffer from low stability and PL quantum yield (PLQY). While Pb‐free air‐stable perovskites such as Cs2AgInCl6 emit desirable warm white light, sophisticated doping strategies are typically required to increase their PL intensity. Moreover, the use of rare metal‐bearing compounds along with the typically required vacuum‐based thin‐film processing may greatly increase their production cost. Herein, organic–inorganic hybrid cuprous (Cu+)‐based metal halide MA2CuCl3 (MA = CH3NH3+) that meets the requirements of i) nontoxicity, ii) high PLQY, and iii) dopant‐free is presented. Both single crystals and thin films of MA2CuCl3 can be facilely prepared by a low‐cost solution method, which demonstrate bright warm white‐light emission with intrinsically high PLQYs of 90–97%. Prototype electroluminescence devices and down‐conversion LEDs are fabricated with MA2CuCl3 thin films and single crystals, respectively, which show bright luminescence with decent efficiencies and operational stability. These findings suggest that MA2CuCl3 has a great potential for the single‐component indoor lighting and display applications.
Transparent, Multivalued Transistors Enabled By Area‐Selective Optical Doping on Ga‐Doped IZTO Thin Films
Authors: Kim Jihyun , Lee Ju Hyeon , Jung Myeongjin , Kim Jae Hyung , Park Jung‐Min , Kim Han‐Ki , Kang Joohoon 
Published: September 2022

AbstractMultivalued transistors are demonstrated on wafer‐scale, sputtered gallium‐doped indium‐zinc‐tin‐oxide (Ga‐doped IZTO) thin films by area‐selective optical doping. Cation elemental doping and ultraviolet (UV) exposure are representative techniques to control the carrier concentrations of metal oxide semiconductors. In this work, both doping techniques are exploited to design a pseudo‐heterojunction on a monolithic Ga‐doped IZTO thin film to generate multivalued electrical characteristics. The resulting semiconductor channel possessed two distinct work functions (i.e., smaller work function on the UV‐exposed area with respect to the masked Ga‐doped IZTO area), which resulted in sequential activation with two turn‐on voltages under a gate voltage sweep. Consequently, a stable intermediate state is generated for the ternary operation of the devices. This work further demonstrates the fabrication of transparent ternary device arrays by utilizing transparent elements including indium tin oxide (ITO), Ga‐doped IZTO, SiO2, and glass as electrodes, semiconducting channels, dielectric layers, and substrates, respectively.
Two‐Dimensional Fluorinated Graphene Reinforced Solid Polymer Electrolytes for High‐Performance Solid‐State Lithium Batteries
Authors: Zhai Pengbo , Yang Zhilin , Wei Yi , Guo Xiangxin , Gong Yongji 
Published: September 2022

AbstractSolid polymer electrolytes (SPEs) hold a great promise in the application of solid‐state lithium batteries, but suffer from poor mechanical properties and uncontrolled electrode/electrolyte interfacial reaction, which restrict their overall electrochemical performance. Herein, the design of 2D fluorinated graphene‐reinforced PVDF‐HFP‐LiTFSI (FPH‐Li) polymer electrolytes to address these challenges is reported. Uniformly dispersed fluorinated graphene induces a unique grain refinement effect, which effectively improves the mechanical properties without excessively increasing the thickness of the polymer electrolyte. Significant reduction in polymer grain size enhances interfacial lithium ion (Li‐ion) transport and homogenizes Li‐ion flux, thereby improving Li‐ion conductivity and promoting uniform Li plating/stripping. Furthermore, extensive characterizations show that fluorinated graphene is involved in the construction of a stable artificial interface, which effectively prevents the side reactions between the lithium metal anode and solvated molecules. As a result, the use of thin FPH‐Li polymer electrolytes (thickness of ≈45 µm) enables long‐term Li plating/stripping with a small overpotential in Li/Li symmetrical cells and stable cycling of Li/LiNi0.6Co0.2Mn0.2O2 full cells with a high average Coulombic efficiency of 99.5% at 1.0 C. This work verifies the effectiveness of 2D materials in improving the comprehensive properties of polymer electrolytes and promotes the applications of SPEs in high‐performance solid‐state lithium batteries.
Polyester‐tethered near‐infrared fluorophores confined in colloidal nanoparticles: Tunable and thermoresponsive aggregation and biomedical applications
Authors: Yang Cangjie , Zhang Wei , Pang Xin , Xiao Fan , Kalva Sandeep Kumar , Zhang Yipeng , Pramanik Manojit , Tian Leilei , Liu Gang , Wang Mingfeng 
Published: September 2022

AbstractIntricate assembly of multiple molecular chromophores assisted by protein scaffolds is essential in tuning the optical absorption and energy transfer in the light‐harvesting complexes of the photosynthetic systems in nature. However, it remains a challenge to achieve such structural complexity and functionality in synthetic polymer‐chromophore systems. Here, we report a series of polyester‐tethered pyrrolopyrrole cyanine derivatives and their colloidal nanoparticles dispersed in water, which show tunable J‐ or H‐aggregation excitonic coupling and near‐infrared fluorescence by precise control of the polymer chain lengths, composition, and temperature. Moreover, the optimal fluorescence or photothermal effect of the J‐aggregate nanoparticles enables broad applications in fluorescence or photoacoustic bioimaging and phototherapy.
Supramolecular chiral polymeric aggregates: Construction and applications
Authors: Zhang Gong , Cheng Xiaoxiao , Wang Yuefei , Zhang Wei 
Published: September 2022

AbstractInspired by the mystery of natural homochirality, the design and construction of artificial chiral systems with special functions including mechanics, chiroptical devices, and chiral separation have aroused the great interest of scientists. Due to its diverse conformations and components, polymers become an excellent candidate to construct artificial chiral aggregates, which provides an opportunity to fabricate advanced chiral materials. Herein, in this review, we summarized not only the different strategies for construction and regulation of supramolecular chirality in chiral or achiral polymer systems, mainly including post‐assembly and polymerization‐induced chiral self‐assembly in chiral polymer systems and several chirality transfer and induction strategies in achiral polymer systems, but also the formation mechanisms of chiral aggregates by the chirality amplification from the molecular level to supramolecular level. Furthermore, we present the typical applications of chiral polymeric aggregates in circularly polarized light emission, chiral recognition and separation, and chiral elastomer. Finally, the current challenges and future directions of chiral polymeric aggregates are also elaborated.
Functional role of endothelial transferrin receptor 1 in iron sensing and homeostasis
Authors: Fisher Allison L. , Wang Chia‐yu , Xu Yang , Joachim Kole , Xiao Xia , Phillips Sydney , Moschetta Gillian A. , Alfaro‐Magallanes Victor M. , Babitt Jodie L. 
Published: September 2022

AbstractSystemic iron homeostasis is regulated by the hepatic hormone hepcidin to balance meeting iron requirements while limiting toxicity from iron excess. Iron‐mediated induction of bone morphogenetic protein (BMP) 6 is a central mechanism for regulating hepcidin production. Liver endothelial cells (LECs) are the main source of endogenous BMP6, but how they sense iron to modulate BMP6 transcription and thereby hepcidin is uncertain. Here, we investigate the role of endothelial cell transferrin receptor 1 (TFR1) in iron uptake, BMP6 regulation, and systemic iron homeostasis using primary LEC cultures and endothelial Tfrc (encoding TFR1) knockout mice. We show that intracellular iron regulates Bmp6 expression in a cell‐autonomous manner, and TFR1 mediates iron uptake and Bmp6 expression by holo‐transferrin in primary LEC cultures. In addition, endothelial Tfrc knockout mice exhibit altered iron homeostasis compared with littermate controls when fed a limited iron diet, as evidenced by increased liver iron and inappropriately low Bmp6 and hepcidin expression relative to liver iron. However, endothelial Tfrc knockout mice have a similar iron phenotype compared to littermate controls when fed an iron‐rich standard diet. Finally, ferritin and non‐transferrin bound iron (NTBI) are additional sources of iron that mediate Bmp6 induction in primary LEC cultures via TFR1‐independent mechanisms. Together, our data demonstrate a minor functional role for endothelial cell TFR1 in iron uptake, BMP6 regulation, and hepatocyte hepcidin regulation under iron limiting conditions, and suggest that ferritin and/or NTBI uptake by other transporters have a dominant role when iron availability is high.
Long‐term outcomes and predictors of early response, late relapse, and survival for patients treated with bispecific LV20.19 CAR T‐cells
Authors: Zurko Joanna C. , Fenske Timothy S. , Johnson Bryon D. , Bucklan Daniel , Szabo Aniko , Xu Huiqing , Chaney Katherine , Hamadani Mehdi , Hari Parameswaran , Shah Nirav N. 
Published: September 2022

AbstractWe previously reported results of a first‐in‐human trial of bispecific LV20.19 chimeric antigen receptor T‐cell (CAR‐T) therapy, demonstrating high response rates in patients with relapsed, refractory (R/R) B‐cell malignancies. We now report two‐year survival outcomes and predictors of early response, late relapse, and survival. Patients from the previously reported phase 1 dose escalation and expansion trial of LV20.19 CAR‐T therapy (NCT03019055) treated at target dose of 2.5 × 106 cells/kg (n = 16) were included in this updated analysis. Two‐year progression‐free survival (PFS) and overall survival (OS) were estimated using Kaplan–Meier method. The relationship of in‐vivo CAR‐T expansion, tumor burden, and effector: target ratio on early response (day 28) and late relapse (>180 days post‐CAR‐T) were assessed. Exact log‐rank testing was performed to evaluate the impacts of clinical variables on survival outcomes. With a median of 31 months (range 27–40) of follow‐up, two‐year PFS and OS were 44% and 69%. Median PFS and OS were 15.6 months and not reached, respectively. For CAR‐naïve large B‐cell lymphoma patients (n = 8), two‐year PFS and OS were 50% and 75%. No patient with progression experienced dual target antigen (CD19 or CD20) loss on post‐relapse biopsy. Lower in vivo expansion was strongly associated with late relapse. Early treatment response was impeded by high metabolic tumor volume and low effector: target ratio. Bridging therapy and higher absolute lymphocyte count on day of CAR‐T infusion were associated with inferior survival outcomes. In conclusion, this initial trial of LV20.19 CAR‐T demonstrates a signal for favorable long‐term outcomes for patients with R/R B‐cell malignancies.
Mortality of hospital walk‐in trauma patients: a multicenter retrospective cohort study
Authors: Kakimoto Kohei , Shibahashi Keita , Oishio Masato , Sugiyama Kazuhiro , Hamabe Yuichi 
Published: September 2022

AimTo investigate the characteristics of patients who visited the emergency department by themselves after experiencing trauma and subsequently died, and to identify the prognostic factors of mortality in such patients.MethodsAdult patients with trauma visiting the emergency department by themselves between 2004 and 2019 in Japan were identified using a nationwide trauma registry (the Japan Trauma Data Bank). The characteristics of patients who died were compared with those who survived, and multivariable logistic regression analysis was used to determine the independent association of each preselected variable with in‐hospital mortality (end‐point).ResultsOf the 9753 patients eligible for analysis, 4369 (44.8%) were men, and the median age was 75 years. Of these patients, 130 (1.3%) died in the hospital. The following factors had a significant association with in‐hospital mortality: age, male sex, Charlson Comorbidity Index (CCI) 3–4 and ≥5 with CCI = 0 as a reference, circumstances of injury (free fall and fall at ground level), Glasgow Coma Scale score, Shock Index ≥ 0.9, severe injuries of the head, abdomen and lower extremities, and Injury Severity Score ≥ 15.ConclusionsSeveral risk factors, including older age, male sex, higher CCI, circumstances of injury (free fall and fall at ground level), lower Glasgow Coma Scale score, higher Shock Index, and severe injuries of the head, abdomen, and lower extremities, were identified as being associated with the death of trauma patients visiting the emergency department by themselves. Early identification of patients with these risk factors and appropriate treatment may reduce mortality posttrauma.
Spatiotemporally Targeted Polypeptide Nanoantidotes Improve Chemotherapy Tolerance of Cisplatin
Authors: Yang Jiazhen , Su Tianqi , Zou Haoyang , Yang Guanqing , Ding Jianxun , Chen Xuesi 
Published: September 2022

AbstractThe toxicity of drugs causes various adverse effects in patients. While antidotes that neutralize drug toxicity help reduce systemic damage during clinical therapy, these antidotes are generally accompanied by the loss of drug efficacy. Herein, the spatiotemporally targeted polycystine‐based nanoantidotes were designed as a neutralizer of cisplatin (CDDP) to decrease its toxicity without affecting its anticancer efficacy. The nanoantidotes administered before CDDP selectively accumulated in the liver and kidney and then firmly bound to CDDP through the highly stable Pt−S bond during subsequent chemotherapy. This two‐step administration strategy reduced the level of Pt in normal organs, shortened the half‐life of CDDP in plasma, and increased the tolerance to CDDP. More importantly, the nanoantidotes maintained the anticancer efficacy of CDDP after reducing systemic toxicity, indicating its great potential in expanding the clinical application of CDDP.
Nanopore Electrochemistry for Pathogen Detection
Authors: Ju Yuan , Pu Mengjun , Sun Ke , Song Guiqin , Geng Jia 
Published: September 2022

AbstractPathogen infections seriously threaten human health, and there is an urgent demand for rapid and efficient pathogen identification to provide instructions in clinical diagnosis and therapeutic intervention. Recently, nanopore technology, a rapidly maturing technology which delivers ultrasensitive sensing and high throughput in real‐time and at low cost, has achieved success in pathogen detection. Furthermore, the remarkable development of nanopore sequencing, for example, the MinION sequencer from Oxford Nanopore Technologies (ONT) as a competitive sequencing technology, has facilitated the rapid analysis of disease‐related microbiomes at the whole‐genome level and on a large scale. Here, we highlighted recent advances in nanopore approaches for pathogen detection at the single‐molecule level. We also overviewed the applications of nanopore sequencing in pathogenic bacteria identification and diagnosis. In the end, we discussed the challenges and future developments of nanopore technology as promising tools for the management of infections, which may be helpful to aid understanding as well as decision‐making.
The covariance intersection fusion estimation algorithm weighted by diagonal matrix based on genetic simulated annealing algorithm and machine learning
Authors: Liu Jingang , Hao Gang 
Published: September 2022

SummaryThis paper is concerned with covariance intersection (CI) fusion for multi‐sensor linear time‐varying systems with unknown cross‐covariance. Firstly, a CI fusion weighted by diagonal matrix (DCI) is proposed, and it is proved to be unbiased and robust and has higher accuracy than classical CI fusion. Secondly, the genetic simulated annealing (GSA) algorithm is used for multi‐parameter optimization problem caused by diagonal matrix weights. Considering the serious time‐consuming problem in optimization process of the GSA algorithm, Back Propagation (BP) network is used to obtain the optimal weights. Eventually, the DCI based on GSA algorithm and BP network is proposed. The proposed algorithm has higher accuracy and better stability than classic CI fusion algorithms. Simulation analyses verify the effectiveness and correctness of the conclusion.