bluuebunny/crossref_metadata_2025_split huggingface dataset:
Not in their hands only: hospital hygiene, evidence and collective moral responsibility
Authors: Jukola Saana , Gadebusch Bondio Mariacarla 
Published: November 2022

AbstractHospital acquired infections (HAIs) are a major threat to patient safety. This paper addresses the following question: given what is known about the causes of and possible interventions on HAIs, to whom or what should the moral responsibility for preventing these infections be attributed? First, we show how generating robust evidence on the effectiveness of preventive hygiene measures is a complex endeavour and review the existing evidence on the causes of HAIs. Second, we demonstrate that the existing literature on the ethical aspects of infection control has focused on responsibility at the individual-level. Thirdly, we argue that these accounts do not accommodate systemic factors relevant for HAI prevention. We show that the notion of collective responsibility is useful for making understandable how systemic factors, such as employment conditions in hospitals, are both causally and ethically relevant in infection control.
Piezoelectric Condylectomy Through Transoral Endoscopic Approach: A Cadaveric Study
Authors: Orabona Giovanni Dell’Aversana , Abbate Vincenzo , Maffia Francesco , Romano Antonio , Bonavolontà Paola , Valletta Alessandra , Iaconetta Giorgio , Califano Luigi 
Published: November 2022

AbstractSurgical approaches in the treatment of TMJ pathologies are a much-debated topic in literature. We propose a new surgical approach performed by intraoral access and completed by endoscopic magnification and long-tip piezosurgery assistance. A piezosurgery (Piezosurgery Plus, Mectron s.p.a. 2014) with a long angled tip (MT5-10 L) was used to perform an endoscopically assisted condylectomy.
Potential application of spent mushroom compost (SMC) biochar as low-cost filtration media in heavy metal removal from abandoned mining water: a review
Authors: Madzin Z. , Zahidi I. , Raghunandan M. E. , Talei A. 
Published: November 2022

AbstractOverpopulation and rapid development have put an increasing burden on the environment, leading to various water crisis. Importing water from abandoned mines as an alternative raw water source could be the next answer to alleviate water scarcity problems globally. However, due to its high heavy metals content, there is a need to find an economical and effective method to remove heavy metals before reusing it as potable water source. Biochar, a low-cost and carbon-rich biosorbent, has received increasing attention on its application as a remediating agent to remove heavy metals from water. Previous studies have revealed the potential properties of biochar as a heavy metal removal agent including high cation exchange capacity, high surface area, active surface functional groups, as well as efficient adsorption. Apparently, the most important factor influencing the sorption mechanism is the type of feedstock materials. Spent mushroom compost (SMC), a waste product from mushroom cultivation, has been found as an excellent biosorbent. SMC has received global attention as it is low cost and eco-friendly. It also has been proved as an efficient heavy metals remover from water. Nevertheless, its application as biochar is still scarce. Therefore, this review focuses on the potential of transforming SMC into modified biochar to remove heavy metals, especially from abandoned mining water. The present review emphasizes the current trends in adsorption methods for heavy metal removal from water, assembles data from previous studies on the feedstock of biosorbents to biochars, and discusses the potentials of SMC as a biochar for water treatment.
Relationship Between Hardiness and the Learning Adaptation of Chinese College Students: The Mediating Role of Teacher Support and the Moderating Role of an Only-Child Status
Authors: Li Jun , Huang Jian-Hao , Chen Jian-Yong 
Published: November 2022

AbstractAccording to the Social Cognitive Theory and the perspectives of parental differential treatment, the current research proposed and verified a moderated mediation model to explore the mediating role of teacher support and the moderating role of only-child (OC) /non-only-child (NOC) status in the relationship between hardiness and college student learning adaptation. A questionnaire survey of 1138 Chinese college students was conducted using the hardiness scale, the learning adaptation scale, and the student perception of teacher supportive behavior questionnaire. The results revealed a significant positive effect of hardiness on college student learning adaptation. The mediation model analysis showed that teacher support had a complementary partial mediating role in the relationship between hardiness and college students’ learning adaptation. Furthermore, the moderated mediation model analysis suggested that OC/NOC status moderated the second half of this mediating relationship and indicated that teacher support had a stronger effect on the learning adaptation of college students with OC status than NOC status. The research results not only enrich our understanding of the internal influence mechanism of the relationship between hardiness and college students’ learning adaptation, but also broaden the research on the identity difference between OC/NOC status. Practical discussions and suggestions are proposed based on the results.
AGDS: adaptive goal-directed strategy for swarm drones flying through unknown environments
Authors: Wang Fakui , Huang Jialei , Low Kin Huat , Nie Zisen , Hu Tianjiang 
Published: November 2022

AbstractThis paper aims to address a challenging problem of a drone swarm for a specific mission by reaching a desired region, through an unknown environment. A bio-inspired flocking algorithm with adaptive goal-directed strategy (AGDS) is proposed and developed for the drones swarmed across unknown environments. Each drone employs a biological visual mechanism to sense obstacles in within local perceptible scopes. Task information of the destination is only given to a few specified drones (named as informed agents), rather than to all other individual drones (uninformed agents). With the proposed flocking swarm, the informed agents operate collectively with the remaining uninformed agents to achieve a common and overall mission. By virtue of numerical simulation, the AGDS and non-adaptive goal-directed strategy (non-AGDS) are both presented and evaluated. Experiments by flying six DJI Tello quadrotors indoor are conducted to validate the developed flocking algorithm. Additional validations within canyon-like complicated scenarios have also been carried out. Both simulation and experimental results demonstrate the efficiency of the proposed swarm flocking algorithm with AGDS.
Influence of sample preparation method on static liquefaction behaviour of geotextile reinforced sandy soil
Authors: Denine Sidali , Della Noureddine , Benziane Mehdi Missoum , Feia Sadok 
Published: November 2022

AbstractThis paper aims to evaluate the influence of soil deposition methods on the shear strength of reinforced sand using a triaxial test. Non-woven geotextile layers were used as reinforcement in the experiment to reconstitute specimens of natural sand prepared at loose relative density (Dr = 30%). Arrangements of reinforcement layers (0, 1 and 2 layers) on soil samples were prepared using two different deposition methods [dry funnel pluviation (DFP) and wet deposition (WD)] and consolidated under three levels of confining pressures. Result shows that geotextile inclusion improves the mechanical behavior of sand; a significant increase in the shear strength is obtained by adding up layers of reinforcement. However, it reveals also that the soil-geotextile reinforcement interface efficiency is directly related to the number of layers and the soil dispositional method as well as their initial state. Since, the DFP method exhibits samples strain hardening compared to the WD samples which is very sensitive to static liquefaction. It is important to note that the difference in behavior of test on reinforced WD samples was attributed to the strain at failure, where unreinforced soil tested at ($${\text{p}}_{{\text{c}}}^{{\prime }} = {50}\,{\text{kPa}}$$

p

c

′

=
50

kPa

) has attained complete liquefaction at small stain (εfa = 1.6% for sample tested at 50 kPa of confining pressure) compared to reinforced samples tests in which failure envelope be found for more axial strain.
Impact of “sachet water” microplastic on agricultural soil physicochemistry, antibiotics resistance, bacteria diversity and function
Authors: Edet Uwem Okon , Joseph Akaninyene Paul , Nwaokorie Francisca O. , Okoroiwu Henshaw Uchechi , Udofia Udeme Uyom , Ibor Oju R. , Bassey Ini Ubi , Atim Asitok David , Edet Bassey Okon , Bassey Dokwo Edet , Nkang Ani 
Published: November 2022

AbstractNigeria's most consumed potable water plastic wastes are indiscriminately dumped into agricultural soil despite their ability to become microplastics. The study evaluates the potential impacts of these microplastics on soil physico-chemical parameters, soil bacterial diversity and functions as well as antibiotic resistance. Soil sample was collected using a sterile hand-held auger and its physico-chemical parameters evaluated. Baseline microplastic concentration was determined via the flotation method while microbial isolates were obtained from the test (enriched with microplastics) and control samples using cultural technique and metagenomics. Metagenomic next-generation sequencing (mNGS) was done using the Illumina Miseq platform. The cluster of orthologous genes (COG) tool was used in the prediction of bacterial functional roles. Replicate readings were analysed using analysis of variance (ANOVA) and means compared using the student’s t test. Observed baseline microplastic concentration was 0.08 particles/g of soil. The addition of the microplastics to the soil sample decreased the concentrations of some metals (iron, zinc, lead and nickel) while cobalt concentration, pH level and microbial counts increased. Microbial count and pH clustered together while iron, magnesium, nitrate, nitrite, chromium, cobalt, total organic carbon, zinc, lead, and nickel showed positive loading values suggesting that the addition of microplastics could alter them. Dominant taxa were proteobacteria, unknown, firmicutes at the phyla level. At the level of species, Pseudomonas species dominated microplastics incubated soil while potential pathogenic species such as Klebsiella dominated the control sample. A higher level of multi-drug resistance and altered metabolisms was observed in the test sample. Sachet water microplastics could have serious implications for public health and food security.
Rethinking Committee Work in the Research Enterprise: The Case of Regenerative Gatekeeping
Authors: Lewis Jonathan C. , Alemán‐Díaz Aixa , Behl Mona , Kolesar Sarah , White Lisa , Jones Brandon , Garza Corey , Cooper Sharon 
Published: November 2022

AbstractCommittees touch nearly every facet in the science, technology, engineering, and mathematics research enterprise. However, the role of gatekeeping through committee work has received little attention in Earth and space sciences. We propose a novel concept called, “regenerative gatekeeping” to challenge institutional inertia, cultivate belonging, accessibility, justice, diversity, equity, and inclusion in committee work. Three examples, a hiring committee process, a seminar series innovation, and an awards committee, highlight the need to self‐assess policies and practices, ask critical questions and engage in generative conflict. Rethinking committee work can activate distributed mechanisms needed to promote change.
Land Subsidence Hazard and Building Collapse Risk in the Coastal City of Lagos, West Africa
Authors: Ohenhen L. O. , Shirzaei M. 
Published: November 2022

AbstractEvery year incidents of building collapse claim many lives and cause enormous financial losses around the world, which are often blamed on low‐quality materials, non‐compliance with standards, lack of oversight, and failure to enforce building codes. Here, we highlight the role of land subsidence in triggering unprecedented collapses in the city of Lagos, Nigeria, which has reported over 200 casualties during 152 building failures since 2005. We used acquisitions from radar satellites for 2018–2021 and provided data that link subsidence to foundation damage and high building failure risk in the region. We estimate that an area of 5–81 km2 and 255–4,000 buildings are exposed to a high to very high risk of collapse for short‐term (10 years) to long‐term (75 years) periods. Differential land subsidence can trigger building collapse, and the data presented here will enable authorities to create adequate building codes and standards and devise mitigation strategies.
Understanding Regional Background Ozone by Multiple Methods: A Case Study in the Shandong Region, China, 2018–2020
Authors: Wang F. T. , Zhang K. , Xue J. , Huang L. , Wang Y. J. , Chen H. , Wang S. Y. , Fu J. S. , Li L. 
Published: November 2022

AbstractUprising ground‐level ozone (O3) and its regional pollution in Northern China are attracting more attention. Besides local precursor emissions and photochemistry, background ozone and long‐range transport also contribute significantly to O3 concentrations. To quantify the regional background O3 concentrations and their temporal and spatial variations, multiple methods, including the principal component analysis (PCA) and the Texas Commission on Environmental Quality (TCEQ) method, were applied as a case study in Shandong province in Northern China, where serious O3 pollution occurred frequently yet the background contributions have not been well quantified. We used four methods to quantify the regional background O3: Method 1 is PCA analysis with only ambient O3 data as input; Method 2 is PCA analysis considering O3 and meteorological parameters; Method 3 combines multiple linear regression and the traditional PCA method; and Method 4 is based on TCEQ and consists of the lowest MAD8 O3 measured to represent regional background O3 concentrations. Results derived from multiple methods show an overall consistent trend with 2018–2020 averaged regional background O3 (MDA8) of 41.5 ppb, accounting for 79.4% of the total O3 in the region. From 2018 to 2020, the changes in regional MDA8 O3 estimated by Methods 1–4 are −1.8, 0.7, −2.4, and 0.4 ppb, respectively. Clear seasonal variations in the regional background O3 are observed, showing a pattern of summer > spring > autumn > winter. In addition, the regional ozone contribution at coastal cities was larger than that for inland cities with local O3 contribution gradually increasing from coastal areas to inland areas. The 3‐year average sea‐land breeze contribution to summertime O3 in the eastern coastal cities was estimated to be around 2.1%, while the local photochemistry to O3 in the inland cities was about 29.7% during ozone pollution episodes, with maximum contribution estimated up to 55.8%. Overall, our study provides insights into the regional background ozone and local photochemistry in Northern China.
Determining Emplacement Conditions and Vent Locations for Channelized Lava Flows Southwest of Arsia Mons
Authors: Flynn I. T. W. , Crown D. A. , Ramsey M. S. 
Published: November 2022

AbstractThe lava flow field southwest of Arsia Mons, Mars has complex volcanic geomorphology. Overlapping flows make observations of their total lengths and identification of their source vents impossible. Application of flow emplacement models, which rely upon physical parameters such as flow length, using only the exposed flow may produce inaccurate estimates of effusion rate, viscosity, and yield strength. We use an established terrestrial thermorheological model (PyFLOWGO), modified to Mars conditions, to estimate effusion rates, viscosities, yield strengths, and possible vent locations for five Mars flows. Our investigation found a range of effusion rates from 2,500 to 6,750 m3 s−1 (average of ∼4,960 m3 s−1). These results are an order of magnitude higher than terrestrial channelized basaltic flows. Corresponding modeled viscosities and yield strengths ranged from 9.4 × 103 to 6.6 × 105 Pa s (average of 5.5 × 104 Pa s) and 66 to 381 Pa (average of 209 Pa), respectively. A novel secondary application of PyFLOWGO that assumes upslope channel narrowing provided estimates of the entire channel length, which is on average four times longer than the exposed portions. Projecting these lengths upslope shows that four of the five flows may have a common vent location, which shares morphologic similarities to other Tharsis region vents. This modeling approach for partially‐exposed lava flows makes it possible to not only determine eruptive parameters, but also to estimate total channel lengths and thereby identify possible source vents.
Sex differences in preclinical models of hypertension
Authors: Olivera Sol , Graham Delyth 
Published: November 2022

AbstractHypertension remains the primary contributor in the development of cardiovascular disease which is rapidly increasing worldwide. High blood pressure affects men and women differently and understanding these sex differences is the ultimate unmet need for researchers in this field. Due to the inherent differences in hypertension prevalence, control and outcomes between men and women, novel research needs to be carried out to tackle these disparities and improve targeted treatment. Animal models of hypertension have provided valuable insights into the sexual dimorphism of blood pressure mechanisms. The availability of genetic and non-genetic hypertensive strains allows the opportunity to study diverse environmental and genetic factors that affect blood pressure, therefore presenting a valuable tool for researchers. Sex differences are present before birth and throughout life, which presents a challenge for the study of disease development in humans, but these complexities can be resolved with the use of in vivo models that display similarities to human disease. The aim of the present review is to provide an overview of the different available animal models of hypertension that present sexual dimorphisms and to discuss their relevance to humans.
Perceived stress as a predictor of eating behavior during the 3-year PREVIEW lifestyle intervention
Authors: Jalo Elli , Konttinen Hanna , Westerterp-Plantenga Margriet , Adam Tanja , Drummen Mathijs , Huttunen-Lenz Maija , Siig Vestentoft Pia , Martinez J. Alfredo , Handjiev Svetoslav , Macdonald Ian , Brand-Miller Jennie , Poppitt Sally , Swindell Nils , Lam Tony , Navas-Carretero Santiago , Handjieva-Darlenska Teodora , Taylor Moira , Muirhead Roslyn , Silvestre Marta P. , Raben Anne , Fogelholm Mikael 
Published: November 2022

Abstract
Background
To better support participants to achieve long-lasting results within interventions aiming for weight loss and maintenance, more information is needed about the maintenance of behavioral changes. Therefore, we examined whether perceived stress predicts the maintenance of changes in eating behavior (flexible and rigid restraint of eating, disinhibition, and hunger).

Methods
The present study was a secondary analysis of the PREVIEW intervention including participants with overweight (BMI ≥ 25 kg/m2) at baseline and high risk of type 2 diabetes (n = 1311). Intervention included a 2-month low-energy diet phase and a 34-month subsequent weight maintenance phase. The first 6 months were considered an active behavior change stage and the remaining 2.5 years were considered a behavior maintenance stage. Eating behavior was measured using the Three Factor Eating Questionnaire and stress using the Perceived Stress Scale. The associations between stress and eating behavior were analyzed using linear mixed effects models for repeated measurements.

Results
Perceived stress measured after the active behavior change stage (at 6 months) did not predict changes in eating behavior during the behavior maintenance stage. However, frequent high stress during this period was associated with greater lapse of improved flexible restraint (p = 0.026). The mean (SD) change in flexible restraint from 6 to 36 months was −1.1 (2.1) in participants with frequent stress and −0.7 (1.8) in participants without frequent stress (Cohen’s ds (95% CI) = 0.24 (0.04–0.43)). Higher perceived stress at 6 months was associated with less flexible restraint and more disinhibition and hunger throughout the behavior maintenance stage (all p < 0.001).

Conclusions
Perceived stress was associated with features of eating behavior that may impair successful weight loss maintenance. Future interventions should investigate, whether incorporating stress reduction techniques results in more effective treatment, particularly for participants experiencing a high stress level.
Cadmium-induced apoptosis of Leydig cells is mediated by excessive mitochondrial fission and inhibition of mitophagy
Authors: Yi Lingna , Shang Xue-Jun , Lv Linglu , Wang Yixiang , Zhang Jingjing , Quan Chao , Shi Yuqin , Liu Yunhao , Zhang Ling 
Published: November 2022

AbstractCadmium is one of the environmental and occupational pollutants and its potential adverse effects on human health have given rise to substantial concern. Cadmium causes damage to the male reproductive system via induction of germ-cell apoptosis; however, the underlying mechanism of cadmium-induced reproductive toxicity in Leydig cells remains unclear. In this study, twenty mice were divided randomly into four groups and exposed to CdCl2 at concentrations of 0, 0.5, 1.0 and 2.0 mg/kg/day for four consecutive weeks. Testicular injury, abnormal spermatogenesis and apoptosis of Leydig cells were observed in mice. In order to investigate the mechanism of cadmium-induced apoptosis of Leydig cells, a model of mouse Leydig cell line (i.e. TM3 cells) was subjected to treatment with various concentrations of CdCl2. It was found that mitochondrial function was disrupted by cadmium, which also caused a significant elevation in levels of mitochondrial superoxide and cellular ROS. Furthermore, while cadmium increased the expression of mitochondrial fission proteins (DRP1 and FIS1), it reduced the expression of mitochondrial fusion proteins (OPA1 and MFN1). This led to excessive mitochondrial fission, the release of cytochrome c and apoptosis. Conversely, cadmium-induced accumulation of mitochondrial superoxide was decreased by the inhibition of mitochondrial fission through the use of Mdivi-1 (an inhibitor of DRP1). Mdivi-1 also partially prevented the release of cytochrome c from mitochondria to cytosol and attenuated cell apoptosis. Finally, given the accumulation of LC3II and SQSTM1/p62 and the obstruction of Parkin recruitment into damaged mitochondria in TM3 cells, the autophagosome-lysosome fusion was probably inhibited by cadmium. Overall, these findings suggest that cadmium induces apoptosis of mouse Leydig cells via the induction of excessive mitochondrial fission and inhibition of mitophagy.
ALKBH5-mediated m6A modification of lincRNA LINC02551 enhances the stability of DDX24 to promote hepatocellular carcinoma growth and metastasis
Authors: Zhang Hongwei , Liu Yachong , Wang Wei , Liu Furong , Wang Weijian , Su Chen , Zhu He , Liao Zhibin , Zhang Bixiang , Chen Xiaoping 
Published: November 2022

AbstractAs the most important RNA epigenetic regulation in eukaryotic cells, N6-metheyladenosine (m6A) modification has been demonstrated to play significant roles in cancer progression. However, this modification in long intergenic non-coding RNAs (lincRNAs) and the corresponding functions remain elusive. Here, we showed a lincRNALINC02551was downregulated by AlkB Homolog 5 (ALKBH5) overexpression in a m6A-dependent manner in hepatocellular carcinoma (HCC). Functionally,LINC02551was required for the growth and metastasis of HCC. Mechanistically,LINC02551, a bona fide m6A target of ALKBH5, acted as a molecular adaptor that blocked the combination between DDX24 and a E3 ligase TRIM27 to decrease the ubiquitination and subsequent degradation of DDX24, ultimately facilitating HCC growth and metastasis. Thus, ALKBH5-mediatedLINC02551m6A methylation was required for HCC growth and metastasis.