bluuebunny/crossref_metadata_2025_split huggingface dataset:
Satisfactory clinical and radiologic outcomes with a new shorter and modular stem for end-stage hip osteoarthritis: an international prospective multicentre pilot study
Authors: D’Ambrosi Riccardo , Toni Aldo , Czubak Jaroslaw , Guadilla Jorge , Lieber Lawrence , Mariani Ilaria , Ursino Nicola 
Published: April 2022

Introduction: This multicenter prospective cohort study aimed to assess the safety and clinical and radiologic performance of the CLS® BreviusTM Stem with Kinectiv® Technology. Material and Methods: A total of 222 consecutive subjects, recruited in five different centers, qualifying for primary total hip arthroplasty (THA), were enrolled in the study. All the subjects received the CLS® BreviusTM Stem with Kinectiv® Technology. All the enrolled study subjects underwent pre-operative clinical and radiographic evaluation. Additionally, all subjects underwent post-operative clinical, functional and radiographic evaluations at 6 months and 1, 2, 3, and 5 years. These evaluations included implant survival, pain and functional performance (Harris Hip Score [HHS], University of California, Los Angeles [UCLA] Activity Score, Oxford Hip Score), subject quality-of-life (EQ-5D), radiographic parameters, complications, and concentration of metal ions (aluminum and titanium) in blood. Results: No revisions were performed during the follow-up period. Of the 222 patients, only 76 completed the 5-year follow-up. Only 7 and 5 patients had aluminum and titanium 5-year evaluations, respectively. All the clinical parameters showed an overall improvement in the overtime measured with ANOVA for repeated measures; furthermore, the clinical scores showed a statistically significant improvement at 5 years with respect to pre-operative value (p < 0.001). Aluminum and titanium showed no variation for repeated measures at different time points (p > 0.05). A total of six complications were reported, of which only two were hip-related. Conclusions: The function of the CLS® BreviusTM Stem with Kinectiv® Technology indicated that subject well-being significantly increased following THA regardless of age, gender, BMI, previous surgery, primary diagnosis, and lifestyle.
Kleine Mittel im Fokus
Authors: Stern Cornelia 
Published: April 2022

SummaryIn der Gemmotherapie wird das Meristem von Pflanzen, also das sich schnell teilende Gewebe der Pflanzenknospen oder Triebspitzen, zu Mitteln verarbeitet. Die Anwendung erfolgt über das Sprühen in den Mund. Zu den weniger bekannten Gemmomitteln gehören unter anderem die Mittel aus Speierlings- und Maulbeerknospen sowie Triebspitzen der Libanonzeder und der Besenheide. Vergleiche mit der Volksheilkunde können helfen, die Wirkungen der Knospen zu differenzieren.
Pflanzen zeigen den Weg
Authors: Stumpf Ursula 
Published: April 2022

SummaryPhytoKinesiologie vereint Pflanzenheilkunde mit Kinesiologie, einem körpereigenen Biofeedbacksystem. Der kinesiologische Muskeltest zeigt dabei Blockaden und Möglichkeiten auf. Im Gespräch wird ein Ziel mithilfe einer Pflanze definiert. Hindernisse wie Glaubenssätze und energetische Blockaden werden aufgespürt und notiert. In dem Behandlungsschritt Balance kommen Mensch und Pflanze in einer Fantasiereise in Kontakt, und die Impulse der Pflanze können übertragen werden.
Kräuterwein und Arzneibrei für den Bauch
Authors: Eisenmann-Tappe Iris 
Published: April 2022

SummaryVerdauungsbeschwerden zählen zu den wichtigsten Indikationen der Klostermedizin, die sich mit Einflüssen der Humoralpathologie und Protagonisten wie Walahfrid Strabo, Odo Magdunensis oder Hildegard von Bingen vom 8. bis ins 12. Jahrhundert erstreckt. Als Darreichungsformen haben sich Kräuterplätzchen (Trochisci), Arzneibreie (Latwergen), Milchauszüge und Medizinalweine bewährt, die in ihrer Auszugskraft oftmals über den heute gebräuchlicheren Teeauszug hinausgehen. Mittelalterliche Zubereitungen, mit Beispielen in diesem Beitrag, können mit geringen Modifikationen bis heute als wirkkräftige Therapeutika gegen Verdauungsbeschwerden angewandt werden.
Aromatherapie: Rezepturen für das Lymphsystem
Authors: Herber Sabrina , Zimmermann Eliane 
Published: April 2022

SummaryAls ätherische Öle wirken unter anderem Lorbeer und Immortelle entstauend auf das Lymphsystem. Die Anwendung kann unter anderem Lymphdrainagen begleiten. Das fette Calophyllumöl mag für westliche Nasen gewöhnungsbedürftig sein, seine abschwellenden und wundheilungsfördernden Eigenschaften sprechen jedoch für sich. Die Autorinnen stellen eine Fülle von Rezepturen vor – bei Lymphstau, Lymphödemen und mehr, für zu Hause und unterwegs.
The Utility of Early Brain MRI for Patients with Neurofibromatosis Type 1 and Optic Pathway Glioma: A Long-Term Follow-Up in a Tertiary Referral Hospital
Authors: Rony Cohen , Aharoni Sharon , Halevy Ayelet 
Published: April 2022

AbstractScreening studies have shown detection of optic pathway gliomas (OPGs) in 8 to 31% of children with neurofibromatosis type 1 (NF1). Many of those affected show prolonged indolent phases, but others develop vision disturbances even before diagnosis and treatment. We assessed the clinical presentation at diagnosis, location, natural progression, and risk factors for impaired vision of OPG. The clinical database of the NF1 multidisciplinary clinic of Schneider Children's Medical Center of Israel was reviewed for all patients diagnosed and followed with NF1 during 2007 to 2019. OPG was diagnosed by hyperintensity and thickening along the optic pathway on T2-weighted brain magnetic resonance imaging (MRI), with or without contrast enhancement. Of 257 children with NF1 who underwent MRI, 57 (22%) were diagnosed with OPG; 31 (54%) were females. Twenty-five (44%) had familial NF1. Fifteen (26%) who exhibited tumor progression and worsening in ophthalmic examinations required treatment. Post-chiasmatic glioma was a predictive factor for treatment (p < 0.05), whereas MRI done later and female gender were not significant. Four patients who eventually needed therapy had normal ophthalmic examinations at least 1 year prior to their first MRI. For 6 (40%) of the patients treated, vision continued to worsen. Our findings demonstrate that normal ophthalmic examinations do not always exclude OPG in children with NF1. Early brain MRI before age 36 months may detect OPG, lead to better follow-up and early treatment, and help improve vision outcome.
The Mechanism of Hyperoxia-Induced Neonatal Renal Injury and the Possible Protective Effect of Resveratrol
Authors: Shen Yunchuan , Yuan Yuan , Dong Wenbin 
Published: April 2022

With recent advances in neonatal intensive care, preterm infants are surviving into adulthood. Nonetheless, epidemiological data on the health status of these preterm infants have begun to reveal a worrying theme; prematurity and the supplemental oxygen therapy these infants receive after birth appear to be risk factors for kidney disease in adulthood, affecting their quality of life. As the incidence of chronic kidney disease and the survival time of preterm infants both increase, the management of the hyperoxia-induced renal disease is becoming increasingly relevant to neonatologists. The mechanism of this increased risk is currently unknown, but prematurity itself and hyperoxia exposure after birth may predispose to disease by altering the normal trajectory of kidney maturation. This article reviews altered renal reactivity due to hyperoxia, the possible mechanisms of renal injury due to hyperoxia, and the role of resveratrol in renal injury.
Key Points
The Validity of Positive Coagulase-Negative Staphylococcus Cultures for the Diagnosis of Sepsis in the Neonatal Unit
Authors: Benenson Shmuel , Cohen Matan J. , Greenglick Nofar , Schwartz Carmela , Eventov-Friedman Smadar , Ergaz Zivanit 
Published: April 2022

Objective Coagulase-negative Staphylococcus (CoNS) is the most frequent pathogen causing late-onset sepsis (LOS) in neonatal intensive care units (NICUs). Technical difficulties hinder blood culture (BC) collection and obtaining only one culture before initiating antibiotic therapy is a common practice. We sought to assess specific clinical information and CoNS cultures for the diagnosis of true bacteremia in the NICU.
Study Design This historical cohort study was conducted in NICUs at the Hadassah-Hebrew University Medical Center of Jerusalem in Israel. Clinical and laboratory data in every CoNS bacteremia were collected and compared between bacteremia groups as follows: true positive, two positive BCs; contaminant, one positive BC out of two; undefined, one BC obtained and found positive.
Results For 3.5 years, CoNS was isolated in 139 episodes. True positive was identified in 44 of 139 (31.7%), contaminant in 42 of 139 (30.2%), and the event was undefined in 53 of 139 (38.1%). Vancomycin treatment was more frequent in the true positive and undefined groups than the contaminant group (100, 90.6, and 73.8% respectively, p = 0.001); treatment was also prolonged in these two groups (p < 0.001). No clinical variables were associated with true bacteremia on multivariable analysis.
Conclusion Diagnosis should definitely be based on at least two positive BCs, despite objective difficulties in obtaining BCs in neonates.
Key Points
Maternal Diabetes and Intrapartum Fetal Electrocardiogram
Authors: Plunkett Beth A. , Weiner Steven J. , Saade George R. , Belfort Michael A. , Blackwell Sean C. , Thorp John M. , Tita Alan T. N. , Miller Russell S. , McKenna David S. , Chien Edward K. S. , Rouse Dwight J. , El-Sayed Yasser Y. , Sorokin Yoram , Caritis Steve N. ,   for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units (MFMU) Network*
Published: April 2022

Objective Fetal electrocardiogram (ECG) ST changes are associated with fetal cardiac hypoxia. Our objective was to evaluate ST changes by maternal diabetic status and stage of labor.
Methods This was a secondary analysis of a multicentered randomized-controlled trial in which laboring patients with singleton gestations underwent fetal ECG scalp electrode placement and were randomly assigned to masked or unmasked ST-segment readings. Our primary outcome was the frequency of fetal ECG tracings with ST changes by the stage of labor. ECG tracings were categorized into mutually exclusive groups (ST depression, ST elevation without ST depression, or no ST changes). We compared participants with DM, gestational diabetes mellitus (GDM), and no DM.
Results Of the 5,436 eligible individuals in the first stage of labor (95 with pregestational DM and 370 with GDM), 4,427 progressed to the second stage. ST depression occurred more frequently in the first stage of labor in participants with pregestational DM (15%, adjusted odds ratio [aOR] 2.20, 95% confidence interval [CI] 1.14–4.24) and with GDM (9.5%, aOR 1.51, 95% CI 1.02–2.25) as compared with participants without DM (5.7%). The frequency of ST elevation was similar in participants with pregestational DM (33%, aOR 0.79, 95% CI 0.48–1.30) and GDM (33.2%, aOR 0.91, 95% CI 0.71–1.17) as compared with those without DM (34.2%). In the second stage, ST depression did not occur in participants with pregestational DM (0%) and occurred more frequently in participants with GDM (3.5%, aOR 2.01, 95% CI 1.02–3.98) as compared with those without DM (2.0%). ST elevation occurred more frequently in participants with pregestational DM (30%, aOR 1.81, 95% CI 1.02–3.22) but not with GDM (19.0%, aOR 1.06, 95% CI 0.77–1.47) as compared with those without DM (17.8%).
Conclusion ST changes in fetal ECG occur more frequently in fetuses of diabetic mothers during labor. ClinicalTrials.gov number, NCT01131260.
Precis: ST changes in fetal ECG, a marker of fetal cardiac hypoxia, occur more frequently in fetuses of diabetic parturients.
Key Points
Changes in Internal Cerebral Vein Pulsation and Intraventricular Hemorrhage in Extremely Preterm Infants
Authors: Tanaka Kenichi , Matsumoto Shirou , Minamitani Youhei , Imamura Hiroko , Yoshimatsu Hidetaka , Nakamura Tomomi , Naramura Tetsuo , Iwai Masanori , Mitsubuchi Hiroshi , Nakamura Kimitoshi 
Published: April 2022

Objectives This study aimed to investigate the relationship between internal cerebral vein (ICV) pulsation and intraventricular hemorrhage (IVH) and to identify the cut-off values that predict IVH. We hypothesized that the severity of ICV flow pulsations was related to IVH severity.
Study Design In this prospective observational study, ICV flow was measured in 61 extremely preterm infants using ultrasonography at every 12 hours until 96 hours after birth and on days 7, 14, and 28. The ICV pulsation index (ICVPI = minimum/maximum ICV speed) was calculated and compared among the groups determined by Papile's IVH classification. The ICVPI cut-off values for IVH were determined by receiver operating characteristic curve analysis.
Results Compared with those in the no IVH (NIVH) group (n = 51), the ICVPI median values in the severe IVH (SIVH; grades 3 and 4) group (n = 5) were lower at 25 to 96 hours and on day 7, whereas those in the mild IVH (MIVH; grades 1 and 2) group (n = 5) were lower at 37 to 60 hours. All SIVH events were initially detected within 60 hours after birth. The ICVPI cut-off values for SIVH were 0.92 at 13 to 24 hours, 0.42 at 25 to 36 hours, 0.58 at 37 to 48 hours, and 0.55 at 49 to 60 hours. Infants whose ICVPI values were below the cut-off value ≥3 times between 13 and 60 hours had a significantly higher SIVH incidence than those whose ICVPI values were below the cut-off value ≤2 times (57.1 vs. 1.9%, p < 0.001).
Conclusion Our results indicate that SIVH had sustained pronounced internal cerebral vein pulsations and that the ICVPI values may help predict SIVH. Further research on strategies to decrease venous pressure for IVH prevention is needed.
Key Points
Identification of the Mismatch Negativity in the Responses of Individual Listeners
Authors: Dalebout Susan D. , Fox Lisa G. 
Published: April 2022

AbstractThe mismatch negativity (MMN) was recorded from normal adults in three stimulus conditions: two contrast conditions and a control condition in which standard and deviant stimuli were identical. Averaged waveforms were analyzed by examiners blind to the evoking stimulus condition. Hit rates, a false alarm rate, and d values were determined based on the number of MMNs identified in each condition. Hit rates were low and the false alarm rate was relatively high, resulting in unacceptably small d values. The relationship between MMN findings and corresponding behavioral discrimination data for individual listeners was not systematic. Factors that may contribute to ambiguity and error in MMN data analysis are discussed.
Abbreviations: ABR = auditory brainstem response, Cz = vertex, Fz = 30 percent of the distance between nasion and inion at the midline, MLR = middle latency response, MMN = mismatch negativity, SNR = signal-to-noise ratio
Speech Recognition with In-the-Ear and Behind-the-Ear Dual-Microphone Hearing Instruments
Authors: Pumford John M. , Seewald Richard C. , Scollie Susan D. , Jenstad Lorienne M. 
Published: April 2022

AbstractThe primary purpose of this study was to compare the overall listening benefit in diffuse noise provided by dual-microphone technology in an in-the-ear (ITE) hearing instrument to that provided by dual-microphone technology in a behind-the-ear (BTE) hearing instrument. Further, the study was designed to determine whether the use of the dual-microphone + the manufacturer's party response algorithm in the ITE and BTE hearing instruments provided listening benefit in diffuse noise over their respective omnidirectional microphone modes. Twenty-four adults with mild to moderately severe sensorineural hearing loss were evaluated while wearing binaural BTE and ITE hearing instruments. The results indicated that the dual-microphone + party response mode did provide significant benefit in diffuse noise for both the ITE (3.27 dB signal-to-noise ratio [SNR] improvement) and BTE (5.77 dB SNR improvement) hearing instruments relative to their respective conventional omnidirectional microphones. No significant difference in performance was found between the ITE and BTE hearing instruments when each device was in the dual-microphone + party response mode. It is concluded that the use of dual-microphone technology in both ITE and BTE hearing instruments can improve speech recognition in diffuse noise.
Abbreviations: BTE = behind the ear, DI = Directivity Index, DSL [i/o] = desired sensation level input/output, HINT = Hearing in Noise Test, ITE = in the ear, KEMAR = Knowles electronic manikin for acoustic research, REAR = real-ear aided response, RECD = real-ear-to-coupler difference, RESR = real-ear saturation response, RTS = reception threshold for sentences, SC + a.R.T = super compression plus adaptive recovery time, SNR = signal-to-noise ratio
Electrophysiologic Signs of Auditory Distraction in Elderly Listeners
Authors: Fisher Amy L. , Hymel Murvin R. , Cranford Jerry L. , DeChicchis Albert R. 
Published: April 2022

AbstractBrain mapping was used to investigate the ability of young and elderly female listeners to attend to /ga/ syllabic events at one ear in the presence of speech babble competition at the opposite ear. An oddball stimulus presentation paradigm was used to record the N1 and P2 components of the late auditory evoked potential (LAEP) from 19 scalp locations. With speech competition, elderly listeners exhibited significantly larger reductions in R, amplitude than did young listeners. The competition produced no changes in N1 amplitude in either group. These findings contrast with those of an earlier study in which age-related reductions in N1 but not P2 amplitude were found when listeners attended to tones rather than speech stimuli in the presence of speech competition. These studies suggest that amplitude reductions in different LAEP components may provide electrophysiologic indices of age-related breakdowns in processing sounds in the presence of competition. Which LAEP components are affected may depend on experimental variables such as task difficulty or the nature of the stimuli (e.g., speech vs nonspeech).
Abbreviations: ANOVA = analysis of variance, CID = Central Institute for the Deaf, EEG = electroencephalographic activity, GFP = global field power, LAEP = late auditory evoked potential, PTA = average of pure-tone threshold hearing levels at 500, 1000, and 2000 Hz, SL = sensation level, SRT = speech reception threshold, WRS = word recognition score
A multi-disciplinary approach for building a common understanding of genetic engineering for malaria control in Burkina Faso
Authors: Pare Toe Lea , Barry Nourou , Ky Anselme D. , Kekele Souleymane , Meda Wilfrid I. , Bayala Korotimi , Drabo Mouhamed , Thizy Delphine , Majorin Olivia , Coche Isabelle , Epopa Patric Stephane , Namountougou Moussa , Dabire Roch K. , Diabate Abdoulaye 
Published: April 2022

AbstractGenetic engineering is a complex topic, even for scientists working in other areas, and even more so for those who lack a formal scientific training. To help gene specialists and affected communities talk with one another, international guidance documents have been published that promote dialogue and exchanges. The current paper explores collaboration among scientists of different disciplines as well as between scientists, the local communities, mediated by theatre actors to develop a conversation about Target Malaria’s work on genetic technologies to modify mosquitoes for malaria elimination in Burkina Faso. It focuses on the co-construction of meaning of key scientific concepts with a view to fostering productive collaboration between scientists and the local community. The community provided feedback on what was shared with them regarding the science being developed in the lab and in the field, which in turn informed aspects of the research itself, and the nature of the collaboration between the scientists and the local community.
How to improve SME performance using iterative random forest in the empirical analysis of institutional complementaritty
Authors: Sannabe Atsushi 
Published: April 2022

AbstractEmpirically investigating the workings of institutional complementarity in organisations has been a challenge in the social sciences domain for a long time. This paper examines data from the World Management Survey (WMS) using a new machine learning method termed as iterative random forest (iRF), which is used in the field of biostatistics. An empirical study of complementarity was conducted in small and medium-sized enterprises using WMS data. The effects of 18 management quality indicators on profitability, growth and viability were examined using machine learning methods (i.e. random forest [RF] and iRF). The analysis revealed the relative importance of whether high performers are properly rewarded, poor performers are reassigned and retrained and the criteria for high and low performance are well established. Furthermore, the study results revealed that the ability to set short-term goals based on a long-term perspective is complementary to many other indicators. These findings are consistent with the findings of a survey study that examined many empirical studies on the workings of institutional complementarity. This indicates that iRF is a credible and promising method for empirical research on institutional complementarity.
Electron transfer and spin–orbit coupling: Can nuclear motion lead to spin selective rates?
Authors: Chandran Suraj S. , Wu Yanze , Teh Hung-Hsuan , Waldeck David H. , Subotnik Joseph E. 
Published: April 2022

We investigate a spin-boson inspired model of electron transfer, where the diabatic coupling is given by a position-dependent phase, eiWx. We consider both equilibrium and nonequilibrium initial conditions. We show that, for this model, all equilibrium results are completely invariant to the sign of W (to infinite order). However, the nonequilibrium results do depend on the sign of W, suggesting that photo-induced electron transfer dynamics with spin–orbit coupling can exhibit electronic spin polarization (at least for some time).
Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease
Authors: Guzmán-Vélez Edmarie , Diez Ibai , Schoemaker Dorothee , Pardilla-Delgado Enmanuelle , Vila-Castelar Clara , Fox-Fuller Joshua T. , Baena Ana , Sperling Reisa A. , Johnson Keith A. , Lopera Francisco , Sepulcre Jorge , Quiroz Yakeel T. 
Published: April 2022

SIGNIFICANCE
Amyloid-β and tau, hallmark pathologies of Alzheimer’s disease (AD), are hypothesized to spread through brain functional networks that are critical for neural communication. Using high-resolution network analyses and positron emission tomography, we showed that greater tau burden was related to functional dysconnectivity of regions associated with memory function and increased connectivity of structures that are important for integrating information in cognitively unimpaired Presenilin-1 E280A carriers, who will develop early-onset AD dementia. These findings enlighten how brain pathology relates to distinct patterns of functional connectivity in regions that are essential for memory and information processing. Elucidating how brain pathology alters functional connections before individuals experience cognitive impairment could help detect AD early and predict disease progression and dementia risk.