bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the International Trauma Questionnaire—Child and Adolescent Version (ITQ-CA) in a Chinese mental health service seeking adolescent sample
Authors: Ho G. W. K. , Liu H. , Karatzias T. , Hyland P. , Cloitre M. , Lueger-Schuster B. , Brewin C. R. , Guo C. , Wang X. , Shevlin M. 
Published: August 2022

Abstract
Background
The International Trauma Questionnaire—Child and Adolescent version (ITQ-CA) is a self-report measure that assesses posttraumatic stress disorder (PTSD) and complex PTSD (CPTSD) based on the diagnostic formulation of the 11th version of the International Classification of Diseases (ICD-11). This study aimed to provide a Chinese translation and psychometric evaluation of the ITQ-CA using a sample of mental-health service seeking adolescents in Mainland China.

Methods
The ITQ-CA was translated and back-translated from English to simplified Chinese and finalized with consensus from an expert panel. Adolescents ages 12–17 were recruited via convenience sampling from an outpatient psychiatric clinic in Mainland China. Participants completed the ITQ-CA; measures of four criterion variables (depression, anxiety, stress, adverse childhood experiences); and the PTSD Checklist for DSM-5 (PCL-5). Construct validity, concurrent validity, and comparison of PTSD caseness between ICD-11 and DSM-5 measures were assessed.

Results
The final sample consisted of 111 Chinese adolescents (78% female; mean age of 15.23), all diagnosed with a major depressive disorder. Confirmatory factor analysis indicated the two-factor second-order model provided optimal fit. All criterion variables were positively and significant correlated with the six ITQ-CA symptom cluster summed scores. In the present sample, 69 participants (62.16%) met symptom criteria for ICD-PTSD or CPTSD using the ITQ-CA, and 73 participants (65.77%) met caseness for DSM-5 PTSD using the PCL-5. Rates of PTSD symptom cluster endorsement and caseness deriving from both diagnostic systems were comparable.

Conclusions
The Chinese ITQ-CA has acceptable psychometric properties and confers additional benefits in identifying complex presentations of trauma-related responses in younger people seeking mental health services.
Risk of tick-borne pathogen spillover into urban yards in New York City
Authors: Gregory Nichar , Fernandez Maria P. , Diuk-Wasser Maria 
Published: August 2022

Abstract
Background
The incidence of tick-borne disease has increased dramatically in recent decades, with urban areas increasingly recognized as high-risk environments for exposure to infected ticks. Green spaces may play a key role in facilitating the invasion of ticks, hosts and pathogens into residential areas, particularly where they connect residential yards with larger natural areas (e.g. parks). However, the factors mediating tick distribution across heterogeneous urban landscapes remain poorly characterized.

Methods
Using generalized linear models in a multimodel inference framework, we determined the residential yard- and local landscape-level features associated with the presence of three tick species of current and growing public health importance in residential yards across Staten Island, a borough of New York City, in the state of New York, USA.

Results
The amount and configuration of canopy cover immediately surrounding residential yards was found to strongly predict the presence of Ixodes scapularis and Amblyomma americanum, but not that of Haemaphysalis longicornis. Within yards, we found a protective effect of fencing against I. scapularis and A. americanum, but not against H. longicornis. For all species, the presence of log and brush piles strongly increased the odds of finding ticks in yards.

Conclusions
The results highlight a considerable risk of tick exposure in residential yards in Staten Island and identify both yard- and landscape-level features associated with their distribution. In particular, the significance of log and brush piles for all three species supports recommendations for yard management as a means of reducing contact with ticks.

Graphical Abstract
Retrospective analysis of the diagnostic accuracy of lung ultrasound for pulmonary embolism in patients with and without pleuritic chest pain
Authors: Nazerian Peiman , Gigli Chiara , Reissig Angelika , Pivetta Emanuele , Vanni Simone , Fraccalini Thomas , Ferraris Giordana , Ricciardolo Alessandra , Grifoni Stefano , Volpicelli Giovanni ,   WINFOCUS and US SIMEU study group, Nazerian Peiman 
Published: August 2022

Abstract
Background
Lung ultrasound (LUS) has a role in the diagnosis of pulmonary embolism (PE) mainly based on the visualization of pulmonary infarctions. However, examining the whole chest to detect small peripheral infarctions by LUS may be challenging. Pleuritic pain, a frequent presenting symptom in patients with PE, is usually localized in a restricted chest area identified by the patient itself. Our hypothesis is that sensitivity of LUS for PE in patients with pleuritic chest pain may be higher due to the possibility of focusing the examination in the painful area. We combined data from three prospective studies on LUS in patients suspected of PE and extracted data regarding patients with and without pleuritic pain at presentation to compare the performances of LUS.

Results
Out of 872 patients suspected of PE, 217 (24.9%) presented with pleuritic pain and 279 patients (32%) were diagnosed with PE. Pooled sensitivity of LUS for PE in patients with and without pleuritic chest pain was 81.5% (95% CI 70–90.1%) and 49.5% (95% CI 42.7–56.4%) (p < 0.001), respectively. Specificity of LUS was similar in the two groups, respectively 95.4% (95% CI 90.7–98.1%) and 94.8% (95% CI 92.3–97.7%) (p = 0.86). In patients with pleuritic pain, a diagnostic strategy combining Wells score with LUS performed better both in terms of sensitivity (93%, 95% CI 80.9–98.5% vs 90.7%, 95% CI 77.9–97.4%) and negative predictive value (96.2%, 95% CI 89.6–98.7% vs 93.3%, 95% CI 84.4–97.3%). Efficiency of Wells score + LUS outperformed the conventional strategy based on Wells score + d-dimer (56.7%, 95% CI 48.5–65% vs 42.5%, 95% CI 34.3–51.2%, p = 0.02).

Conclusions
In a population of patients suspected of PE, LUS showed better sensitivity for the diagnosis of PE when applied to the subgroup with pleuritic chest pain. In these patients, a diagnostic strategy based on Wells score and LUS performed better to exclude PE than the conventional strategy combining Wells score and d-dimer.
A spontaneous reduction in tumor size of a thymic carcinoma: a case report
Authors: Kuroki Shoei , Ayabe Takanori , Tanaka Hiroyuki , Nakada Hiroshi , Maeda Ryo 
Published: August 2022

Abstract
Background
Spontaneous regression of thymic carcinoma is extremely rare. We report a case of a resected thymic carcinoma with preoperative spontaneous regression in a 67-year-old woman.

Case presentation
The patient presented with low-grade fever and anterior chest pain. Chest computed tomography (CT) showed a 55 × 43 mm exophytic heterogeneously enhancing mass showing some areas of necrosis. Chest CT done one day preoperatively revealed that the tumor had rapidly shrunk for one month. Surgical resection was performed to obtain a definitive diagnosis and achieve complete resection, yielding a postoperative diagnosis of thymic carcinoma. The patient survived without signs of recurrence for 12 months postoperatively.

Conclusions
Mediastinal tumors with necrosis demonstrating spontaneous regression should include thymic carcinomas in the differential diagnosis.
Regression of choroidal metastasis from breast carcinoma with palbociclib
Authors: Parakh Shweta , Das Shrutanjoy , Maheshwari Shrey , Gupta Vinita , Luthra Gaurav , Luthra Saurabh 
Published: August 2022

Abstract
Background
Uveal metastasis is reported to be the most common intraocular malignancy. The most common site of origin of ocular metastases in females is the breast. In some cases, uveal metastatic lesions respond to systemic chemotherapy. We report a case of a patient who developed choroidal metastasis, while on endocrine therapy with selective estrogen receptor modulator (SERM), tamoxifen, for estrogen receptor (ER) positive, progesterone receptor (PR) positive and (human epidermal growth factor receptor 2) HER2 negative primary breast carcinoma, which then regressed following systemic chemotherapy with palbociclib.

Case description
An 83-year-old female, with a history of modified radical mastectomy, chemotherapy and radiation therapy for infiltrating duct carcinoma of the breast, presented with a choroidal metastatic lesion in the left eye along with liver and lung metastases, 3 years after the primary carcinoma was treated. At the time of presentation, she was on tamoxifen. The choroidal tumor showed regression after the introduction of palbociclib, a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor.

Conclusion
This report highlights the use of palbociclib, in the palliative treatment of choroidal metastasis from primary breast cancer. The use of chemotherapy for choroidal metastasis can help avoid external beam radiation therapy and its concurrent side effects. Although there are a few reports involving the use of palbociclib for metastatic breast carcinoma, all of those have been in conjunction with and/or following non-response to other treatment modalities. Ours is the first report wherein palbociclib has been used as the first-line palliative chemotherapy and helped in regression of choroidal metastasis.
Partnership dynamics and the fertility gap between Sweden and Spain
Authors: Nishikido Momoko , Cui Qi , Esteve Albert 
Published: August 2022

AbstractBelow-replacement fertility has persisted across European countries for a few decades, though, with variation. Delays in age at first union and first birth have been key factors in the declining fertility levels within these societies. While the vast majority of births occurs within a stable partnership, the link between partnership formation and childbearing is rarely taken into account. In this paper, we examine the role of partnership formation in explaining the gap between Sweden and Spain regarding transitions to first birth. We utilize data from the 2018 Spanish Fertility Survey and the 2012/2013 Swedish Generations and Gender Survey to explore transition probabilities to first birth and implement Kitagawa decomposition and standardization techniques. Results show that having a partner is a strong predictor of becoming a first-time parent in the next 3 years, mainly within the ages 25 to 35. On average, Swedish first-birth transition probabilities for women are only 12% higher than probabilities of Spanish counterparts within this age range, suggesting that the proportion of partnerships formed plays a crucial role in explaining the fertility gap. Decomposition results confirm that before age 30, 74% of the difference in first-order births among women are due to the difference in partnership composition. We further find that earlier union formation in Spain could potentially reduce childlessness levels. Overall, our study highlights the importance of examining the role of partnership dynamics in fertility studies.
Priorities for rheumatic and musculoskeletal disease research in Ireland
Authors: Dorris Emma R. , Grealis Stacey , Kegl Karmen , Kennedy Norelee , Larkin Louise , Lynch Brian , Moran Ailis , O’Brien Justine , Skeffington Stephanie , Slater Kayleigh , Ward Rebecca , Willett Allison 
Published: August 2022

Abstract
Background
Research priority setting is a useful approach to decide which unanswered questions are most worth trying to solve through research. The aim is to reduce bias in the research agenda. Traditionally, research was decided by funders, policymakers, and academics with limited influence from other stakeholders like people living with health conditions, caregivers, or the community. This can lead to research gaps that fail to address these important stakeholder needs. The objective of this study is to identify the top research priorities for Rheumatic and Musculoskeletal Disease (RMD) research in Ireland.

Methods
The process framework included a design workshop, two online surveys and a review of the literature.

Participants
545 people completed the first survey to identify RMD research topics relevant to Ireland, of which 72% identified as a person living with RMD. 460 people completed the second survey to prioritise these research topics.

Results
The first survey had 2185 research topics submitted. These were analysed and grouped into 38 topic areas which were ranked in the second survey. The top three research priorities for RMD research in Ireland focused on preventing RMD progression, RMD diagnosis and its impact, and pain management.

Conclusions
The prioritised research topics indicate important areas of RMD research for Ireland. Research funded in response to these co-created research priorities will have increased relevance and impact.
Eco-friendly control method against invasive pest box tree moth, (Cydalima perspectalis (Walker) (Lepidoptera: Crambidae))
Authors: Tozlu Elif , Tozlu Göksel , Kotan Recep , Tekiner Nasibe , Dadaşoğlu Fatih , Göktürk Temel 
Published: August 2022

AbstractBackgroundBuxus sempervirens(Boxwood) is a type of plant that has economic and cultural significance, danger of extinction due to various factors.Cydalima perspectalis(Walker, 1859) (Lepidoptera: Crambidae), an invasive species, has an important role as a boxwood pest. The inadequacy of the pheromone trap methods recommended to control the pest or the negative effects of chemical insecticides on the environment have led to seeking alternative approaches in this regard. In this study, it was conducted to determine whether entomopathogens can be applied in pest control, the insecticidal effects ofBacillus thuringiensissubsp. kenyae(FDP-8),Bacillus cereus(FD-63),Brevibacillus brevis(FD-1) andVibrio hollisae(FD-70) bacterial strains at the concentration of 1 × 108 CFU/ml andBeauveria bassiana(Bals.-Criv.) Vuill. (Cordycipitaceae) (ET 10) fungal isolate at the concentrations of 1 × 106, 1 × 107and 1 × 108conidia/ml were tested under controlled conditions.ResultsAs compared the results of the bacterial strains and fungal tested, it was determined that the best results were obtained from in the fungal isolate at the concentration of 1 × 108conidia/ml. After 192 and 216 h. of observation, the 1 × 108 CFU/ml of bacterial strains:B. cereusFD-63,B. brevisFD-1 andV. hollisaeFD-70; also, 1 × 108conidia/ml concentration of ET 10 fungal isolate ofB. bassianacontrolC. perspectaliscaused mortality rate of 100% under laboratory conditions.ConclusionFuture studies of these microorganisms against this pest in the field, may be an important alternative method to control this pest.
Comorbidities and outcomes among patients hospitalized with COVID-19 in Upper Egypt
Authors: Khedr Eman M. , Daef Enas , Mohamed-Hussein Aliae , Mostafa Ehab F. , Zein Mohamed , Hassany Sahar M. , Galal Hanan , Hassan Shimaa Abbas , Galal Islam , Zarzour Amro A. , Hassan Hebatallah M. , Amin Mariam Taher , Hashem Maiada K. , Osama Khaled , Gamea Ayman 
Published: August 2022

Abstract
Background
The coronavirus disease 19 (COVID-19) pandemic has spread rapidly around the globe with considerable morbidity and mortality. Coexistence of comorbidities with COVID-19 had consistently been reported as risk factors for unfavorable outcome. We aimed to evaluate the impact of comorbidities in COVID-19 patients on the outcome and determine predictors of prolonged hospital stay, requisite for intensive care unit (ICU) admission. Four hundred and thirty-nine adult patients who are admitted through (June and July 2020) in our University Hospitals were included in the study. All participants were diagnosed with COVID-19 according to Egyptian Ministry of Health guidance as definite case or probable case.

Results
Patients with comorbidities represented 61.7% of all cases. Constitutional symptoms especially myalgia and lower respiratory tract (LRT) symptoms such as dyspnea were significantly higher in patients with comorbidities (P < 0.05). Patients with comorbidities had significantly worse laboratory parameters. ICU admission was higher in patients with comorbidities (35.8%). Among different comorbidities 45.4% of cardiovascular diseases (CVD) cases were admitted in ICU followed by diabetes mellitus (DM) cases (40.8%). Also, patients with comorbidities needed invasive mechanical ventilation more than those without comorbidity (31 versus 10.7%, P < 0.001). Significant lower frequency of recovery was found in COVID-19 patients with comorbidities (59% versus 81%, P < 0.001) and death rate was significantly higher in cases with comorbidities (P < 0.001). The survival rates in cases with pre-existing CVD and neurological diseases were lower than those without disease (P < 0.002 and 0.001, respectively).

Conclusions
Association of cardiovascular comorbid conditions including hypertension or neurological diseases including old cerebrovascular strokes together with COVID-19 infections carries higher risks of mortality. However, other comorbidities such as diabetes mellitus, chronic pulmonary or kidney diseases may also contribute to increased COVID-19 severity.
Genetic investigations pathway for people with intellectual disability, autism and/or epilepsy
Authors: Clark Elaine , Koutsogianni Maria 
Published: August 2022

SUMMARYGenomic medicine is an evolving medical specialty that uses genomic information about an individual as part of their clinical care (e.g. for diagnostic or therapeutic decision-making). It has rapidly grown since the completion of the Human Genome Project in 2003. In England, the National Health Service's Genomic Medicine Service is considered to be the first national healthcare system to offer whole-genome sequencing as part of routine clinical care. Already, genomic medicine is making an impact in the fields of oncology, pharmacology, rare and undiagnosed diseases, infectious disease and neurology. In this article, we present a useful tool kit for clinicians working with individuals with intellectual disability, autism spectrum disorder and epilepsy. This article provides evidence for the importance of genetic testing, conveys an understanding of the range of genetic tests available and their diagnostic yields and how these apply to intellectual disability, autism spectrum disorder and epilepsy. Our simple tool kit gives information on when to refer to a clinical geneticist and where to find resources for clinicians and parents on genetic testing.
Role of Local Evidence in Transferring Evidence-Based Interventions to Low- and Middle-Income Country Settings: Application to Global Cancer Prevention and Control
Authors: Parascandola Mark , Neta Gila , Salloum Ramzi G. , Shelley Donna , Rositch Anne F. 
Published: August 2022

PURPOSE Although the global burden of cancer falls increasingly on low- and middle-income countries (LMICs), much of the evidence for cancer prevention and control comes from high-income countries and may not be directly applicable to LMIC settings. In this paper, we focus on the following question: When the majority of the evidence supporting an evidence-based intervention or implementation strategy comes from high-income countries, what local, contextual evidence is needed when transferring and adapting an intervention or strategy to a specific LMIC setting? METHODS We draw on an existing framework (the Population, Intervention, Environment, Transfer-T process model) for assessing transferability of interventions between distinct settings and apply the model to two case studies as learning examples involving implementation of tobacco use treatment guidelines and self sampling for human papillomavirus DNA in cervical cancer screening. RESULTS These two case studies illustrate how researchers, policymakers, practitioners, and consumers may approach the need for local evidence from different perspectives and with different priorities. As uses and expectations around local evidence may be different for different groups, aligning these priorities through multistakeholder engagement in which all parties participate in defining the questions and cocreating the solutions is critical, along with promoting standardized reporting of contextual factors. CONCLUSION Local, contextual evidence can be important for both researchers and practitioners, and its absence may hinder translation of research and implementation efforts across different settings. However, it is essential for researchers, practitioners, and other stakeholders to be able to clearly articulate the type of data needed and why it is important. In particular, where resources are limited, evidence generation should be prioritized to address real needs and gaps in knowledge.
The Critical Role of Academic Clinical Trials in Pediatric Cancer Drug Approvals: Design, Conduct, and Fit for Purpose Data for Positive Regulatory Decisions
Authors: De Wilde Bram , Barry Elly , Fox Elizabeth , Karres Dominik , Kieran Mark , Manlay John , Ludwinski Donna , Reaman Gregory , Kearns Pamela 
Published: August 2022

PURPOSE For decades, academic clinical trials consortia have collaborated to optimize outcomes for childhood cancers through evaluating incremental improvements in conventional mutimodality treatment regimes. There are now increasing opportunities to partner with industry to test new medicines in academic-sponsored trials, but these collaborative studies rarely contribute to marketing authorizations. We addressed why this is the case and sought solutions to enable academic-sponsored trials to directly contribute to the licensing of new medicines. METHODS Under the auspices of the multistakeholder platform ACCELERATE, we convened a working group of representatives from clinical academia, pharmaceutical industry, European Medicines Agency, US Food and Drug Administration, and patient advocacy to define the challenges and propose recommendations to facilitate academic-sponsored trial design and conduct to be aligned to both the needs of the pharmaceutical company who own the asset and the expectations of the regulatory (licensing) authorities. RESULTS We identified that although academic consortia have long-standing expertise to conduct robust clinical trials, there were critical gaps in knowledge, standard procedures, and resources that hindered the trial data directly contributing to marketing authorization applications. We propose a suite of recommendations focused on (1) essential documents, (2) essential data, (3) data management, and (4) trial resources, specifically aimed at enabling academic-industry partnerships to deliver an academic-sponsored trial that meets the requirements for a marketing authorization submission. These recommendations pivot around transparency in academic-industry partnerships and early engagement with regulators. CONCLUSION Academic sponsors and industry partners need to prospectively recognize when the planned collaborative trial could contribute to an application to marketing authorization and plan accordingly. Transparent collaboration and knowledge sharing between the partners opens an important pathway for accelerating new treatments into clinical practice for children with cancer.