bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Dermoscopy and Ultrasonography be Considered a Prognostic Tool in Management of Psoriasis?
Authors: Muralidharan Elga , Malhotra Suresh K , Singh Arvinder 
Published: April 2022

Background:
Dermoscopy can reliably predict the diagnosis of plaque psoriasis. Ultrasonography has been increasingly used in dermatology in inflammatory diseases like psoriasis as a tool for evaluation. Hence, this study was done to evaluate the role of dermoscopy and ultrasonography as prognostic aid in plaque psoriasis.

Aims and Objectives:
To study the sonographic and dermoscopic findings of clinically diagnosed psoriatic lesions and the changes in the psoriatic lesions if any, with the treatment. How these findings can be utilized to assess the prognosis in these patients.

Materials and Methods:
The present study comprised 50 patients with clinically diagnosed plaque psoriasis. Lesions were assessed with Dino-Lite digital microscope AM7515MZT, followed by ultrasonography using a 15 MHz probe, and findings were recorded. All the patients included in this study were given appropriate treatment (topical/systemic) for 6 weeks and were followed up twice i.e., at 3 weeks and 6 weeks after initiating treatment.

Results:
Whitish scales were the most common scale color seen in our study seen in 35/50 patients (70%). All the vascular structures were reddish, red dots and globules being the predominant type and with the improvement of the lesions, brown structures increased. A total of 28 (56%) patients had a regular pattern of vessel arrangement. Mean capillary size was 0.097 ± 0.012 mm that reduced to 0.075 ± 0.019 mm at the end of the third week and 0.027 ± 0.032 mm at the end of 6 weeks. In ultrasonographic assessment, mean epidermal thickness reduced from 0.1008 to 0.0764 cm at third week and 0.068 cm at the sixth week, and mean dermal thickness reduced from 0.2692cm to 0.1906cm at the third week and then to 0.1906cm 0.1806cm at the sixth week. In our study, clinical improvement preceded dermoscopic improvement. Newer structures identified in the study are a perifollicular arrangement of capillaries and the presence of lacunar structures in the healing lesions.

Conclusion:
The scale distribution, capillary number, and capillary size in dermoscopic assessment, and epidermal and dermal thickness in ultrasonography showed statistically significant changes with treatment and thus may be taken as the prognostic indicators. Thus, both these noninvasive modalities may be useful in the therapeutic monitoring of plaque psoriasis.
MicroRNA-31 Overexpression may Aggravate the Formation of Psoriasis-like Lesions by STAT3/p53 Pathway
Authors: Wang Qiang , Wang Chunfang , Zhao Xincheng , Li Xiao , Li Junqin , Hou Ruixia , Yin Guohua , Zhang Kaiming 
Published: April 2022

Background:
Psoriasis is a chronic inflammatory skin disease with an unknown pathogenesis. Recently, miR-31 have been shown to play an important role in psoriasis. Moreover, STAT3/p53 pathway has been used in tumor studies, but rarely in psoriasis studies.

Aims:
The present study aimed to investigate the role of STAT3/p53 pathway in psoriasis-like lesions in a mouse model of miR-31 overexpression.

Methods:
All mice (n = 44) were divided into four groups: normal mice treated with Vaseline® (NV; n = 10), normal mice treated with imiquimod (NI; n = 12), miR-31-overexpressing mice treated with Vaseline® (MV; n = 10), and miR-31-overexpressing mice treated with imiquimod (MI; n = 12). Then, we assayed the expression of STAT3 and p53.

Results:
Our results showed that at the protein level (P < 0.01) and gene level (4.45 times), the expression of STAT3 in the MV group was higher than that in the NV group, and at the protein level (P < 0.01) and gene level (11.43 times), the expression of STAT3 in the MI group was higher than that in the NI group. At the protein level, the expression of p53 in MV group was higher than that in the NV group (P < 0.05), and the expression of p53 in MI group was higher than that in the NI group (P < 0.01).

Conclusions:
Our findings indicate that overexpression of miR-31 causes upregulation of STAT3, which further brings about upregulation of p53, and eventually leads to serious psoriasis skin lesion.
HLA-Cw6 Status and Treatment Responses Between Psoriasis Patients
Authors: Temel Berkay , Adisen Esra , Gonen Sevim 
Published: April 2022

Background
The number of treatment options in psoriasis has increased considerably, so biomarkers should be searched to assist in the selection of the optimal treatment agent. The most common of these biomarkers is HLA-Cw6.

Objective:
The aim was to determine whether there is a relationship between HLA-Cw6-positivity (HLA-Cw6-POS) and the response of treatment agents in psoriasis.

Methods:
Blood samples of 124 patients were subjected to genetic study for HLA-Cw6.

Results:
Psoriasis area severity index (PASI) score of more than 75% (PASI75) response was received in 34 (73.9%) of the HLA-Cw6-POS methotrexate-treated patients, 30 (78.9%) of the HLA-Cw6-POS cyclosporine-treated patients, and 8 (37.5%) of the HLA-Cw6-POS acitretin-treated patients. The differences were not statistically significant (P = 0.634-0.071-0.409). PASI75 response was received in 73 (68.2%) of the HLA-Cw6-POS patients in patients treated with conventional agents. In adalimumab-treated patients, PASI75 response was received in 8 (53.3%) of the HLA-Cw6-POS patients, 6 (75%) of the HLA-Cw6-POS infliximab-treated patients, and 4 (57.1%) of the HLA-Cw6-POS ustekinumab-treated patients. The differences were not statistically significant (P = 0.245-1.00-0.322). PASI75 response was received in 24 (64.9%) of the HLA-Cw6-POS and 33 (84.6%) of HLA-Cw6 negative (HLA-Cw6-NEG) patients with biological agents. The biological agent response was statistically significantly lower in HLA-Cw6-POS.

Conclusion:
None of the agents were affected by HLA-Cw6. When biological agents were evaluated collectively, the treatment response of HLA-Cw6-POS patients was lower.
Iron Deficiency and Pruritus
Authors: Saini Shivani , Jain Akshay K , Agarwal Shail , Yadav Devendra 
Published: April 2022

Background:
As generalized pruritus can be a symptom of a systemic disease, iron deficiency may be the underlying internal cause of its symptoms. Because data on the relationship between iron deficiency and generalized chronic pruritus are limited, more research is needed to ensure proper diagnosis and management.

Aims:
To evaluate the prevalence of iron deficiency in patients with generalized chronic pruritus in the southeast region of Rajasthan and to assess the correlation of serum ferritin with iron deficiency variables.

Materials and Methods:
An observational, analytical study was conducted among a total of 200 patients complaining of itching all across the body without any skin lesions for more than 6 weeks and enrolled in the outdoor and indoor Dermatology, Venereology, and Leprology departments of the Government Medical College, Kota. The duration of the study experiment was 1 year from June 2018 to May 2019.

Results:
Females (108; 54%) were more than males (92; 46%) with a ratio of 1.17:1. The mean age of the patients was 37.35 ± 13.56. S. ferritin was found to be below 15 g/L in 58 (29%) patients. Significant correlation was found between S. ferritin and hemoglobin, MCV, MCH, and MCHC, and the P value was <0.05. Maximum number of patients (70; 35%) achieved visual analog scale (VAS) scores between 4 and 9, followed by 50 (25%) patients obtaining scores >9. Similarly, a correlation was found between the VAS score and hemoglobin, MCV, MCH, and MCHC and a statistically significant P value was obtained.

Limitations:
The sample size was small in the study. The overall levels of iron and serum transferrin were not checked, keeping patients' compliance in mind.

Conclusion:
Although statistically significant results were found, limitations were also present in our study; so, further studies for proper diagnosis and management should be conducted in greater depth.
Clinical-Dermoscopic-Histopathological Correlations in Collision Skin Tumours
Authors: Fikrle Tomas , Divisova Barbora , Pizinger Karel 
Published: April 2022

Objectives:
Collision tumours are rare situations characterised by the coincidence of two different skin neoplasms in the same lesion.

Methods:
We have analyzed 41 collision skin tumours from one department in the clinical-dermoscopic-histopathologic correlations.

Results:
We present 41 collisions tumours. The mean age of our patients was 67.9 years, the mean diameter of the lesion was 11.6 mm. The most frequent locations were trunk (27 lesions) and head/neck (11 lesions). The collisions were classified as benign/benign (13 cases), benign/malignant (25 cases) and malignant/malignant (3 cases). The most frequent participants were seborrheic keratosis (24 cases), malignant melanoma (17 cases), melanocytic nevus (14 cases), basal cell carcinoma (12 cases) and heamangioma (10 cases). Thirty cases were of “dominant/minor” type and 11 cases of “half to half” type. Malignant tumours were a part of 28 collisions; these lesions were larger, patients were older and the malignant part was dominant in most cases. More than half of the collisions were unexpected by the initial clinical examination. Six collisions were missed by the initial histopathological examination.

Conclusions:
Collision tumours can be missed by clinical or even histopathological examination. Dermoscopy is very helpful in the recognizing of difficult cases and cooperating with the histopathologist.
Assessment of the quality of randomized controlled trials in surgery using Jadad score: Where do we stand?
Authors: Mohsina S , Gurushankari B , Niranjan R , Sureshkumar S , Sreenath GS , Kate V 
Published: April 2022

Introduction:
Quality assessment of randomized controlled trials (RCTs) is important to prevent clinical application of erroneous results.

Materials and Methods:
This was an assessment of published RCTs in surgical subspecialties during 2011–2018 based on MEDLINE and EMBASE search. The primary objective of the present study was to quantitatively and qualitatively analyze the RCTs published from India based on year of publication, geographical distribution, and subspecialty using the modified Jadad score (high quality if score is ≥3; or ≥2 if blinded design was not feasible). Its secondary objective was to identify factors affecting the quality of RCTs.

Results:
Among 1304 trials identified, 162 were analyzed. Of these 96 (59%) had a score of ≥3; and 104 (64.2%) were of high quality (score ≥2). Year-wise there was no significant quantitative (P = 0.329) or qualitative (P = 0.255) variation. Geographic regions had similar quantity (P = 0.206) and quality (P = 0.068). The RCTs among subspecialties too were comparable in quantity and quality. Higher impact factor of journal (P = 0.013) and assessment by Institute Review Board (IRB) (P = 0.004) were significantly associated with a better study quality. Type of institution, number of authors, centricity, assistance by a statistician, and source of funding did not affect the quality of RCTs.

Conclusions:
The quantity and quality of surgical RCTs were stable and comparable over the years and across geographical regions and subspecialties. Higher impact factor of journal and review by IRB were significantly associated with a better study quality.
Mutation survey in Taiwanese patients with Stickler syndrome
Authors: Huang Faye , Wang Tzu-Jou , Cho Wan-Hua , Chen Yi-Hao , Wu Pei-Chang , Kuo Hsi-Kung 
Published: April 2022

PURPOSE:
The purpose of this study was to identify gene mutation and phenotype correlations in a cohort of Taiwanese patients with Stickler syndrome.

MATERIALS AND METHODS:
Patients clinically diagnosed with Stickler syndrome or suspected Stickler syndrome were enrolled. DNA was extracted from venous blood samples. For the targeted next-generation sequencing (NGS) approach, specific primers were designed for all COL2A1, COL11A1, COL11A2, COL9A1, and COL9A2 exons and flanking intron sequences.

RESULTS:
Twenty-three patients from 12 families were enrolled in this study. The myopia power in these 23 cases (35 eyes) ranged from −4.625 to −25.625 D, with a median of −10.00 D. Four patients had retinal detachment. Fourteen patients had a cleft palate. These 23 patients and 13 healthy controls were enrolled in the NGS study. Three families had significant single nucleotide variants (SNVs) in COL2A1. The mutation rates in this survey were 25% (3/12 families) and 35% (8/23 cases). The SNV of family #1, located at exon 27, c.1753G >T, p. Gly585Val, was novel and has not yet been reported in the ClinVar database. Families #10 and #11 had the same SNV, located in exon 33, c.2101C >T, p. Arg701X. Both variants were classified as likely pathogenic according to the American College of Medical Genetics and Genomics guidelines.

CONCLUSION:
Genetic mutations in COL2A1 were found in 25% of Taiwanese families with Stickler syndrome. One novel variant was identified using NGS, which expanded the COL2A1 mutation spectrum. Molecular genetic analysis is helpful to confirm the clinical diagnosis of patients with suspected Stickler syndrome.
Iniciação a Vida Cristã a partir da casa e da comunidade
Authors: Bertoldi Marlene , Da Rosa Togneri Silvia Regina , Stippe Maria de Fátima 
Published: April 2022

Este artigo procura demonstrar que a catequese, com inspiração catecumenal, compreende a Igreja como a casa da Iniciação à Vida Cristã, estando construída sobre três pilares: Palavra, Pão e Caridade. A Palavra de Deus, o Pão e a Caridade estão entrelaçados com a Iniciação à Vida Cristã, quando falamos em família-casa-comunidade. A casa, no contexto bíblico, sempre foi muito valorizada como base de uma sociedade que se desenvolve com valores provindos da convivência familiar. É neste convívio que passa de geração a geração a história da aliança, da eleição do povo e da bênção, três elementos que também Jesus recebeu desde a sua infância, na sua catequese familiar. A Iniciação à Vida Cristã realiza-se numa comunidade de irmãos e irmãs, que assume seriamente a vivência da fé. O cultivo da fé não poderá ser terceirizado como tarefa exclusiva da catequese, trata-se, na verdade, de um tripé: a presença na Igreja, principalmente na celebração dominical, a participação ativa nos encontros catequéticos e a vivência da oração em família. Os tempos de pandemia nos colocaram em nova posição para analisar as realidades eclesiais, dentre as quais a catequese. Entre desafios e oportunidades, vislumbramos muitas possibilidades de continuar com empenho o processo de evangelização, com métodos adaptados, personalizados, que não esqueçam a importância dos vínculos comunitários.
Sverdlovsk underground art of 1960–1980s in the Yekaterinburg Museum of Fine Arts — analysis of the collection and development potential
Authors: Пономарёва Н.И. 
Published: April 2022

В статье на основе архивных документов рассматривается история комплектования коллекции свердловского неофициального искусства 1960–1980-х годов в Екатеринбургском музее изобразительных искусств, начиная с 1990-х и заканчивая 2021 годом, анализируется ее состав в контексте существующего в музее собрания отечественного искусства советского периода, представляются перспективы ее дальнейшего развития.
The article focuses on the history of development of Sverdlovsk unofficial art collection in the Yekaterinburg Museum of Fine Arts from the 1990’s to the 2021 as well as it’s analysis in the context of the museum’s collection of Soviet art.
Arthur Vollenweider — the artist, educator herald of urban industrial culture
Authors: Трифонова Г.С. , Казакова Г.М. 
Published: April 2022

Статья посвящена художнику и педагогу уральского города Коркино Артуру Фолленвейдеру, чье наследие стало недавно объектом искусствоведческого и культурологического исследования. Показаны основные этапы биографии и творческого становления художника. Авторы подчеркивают, что актуализация советского наследия в региональных вариациях становится исследовательским мейнстримом, поскольку взгляд на искусство соцреализма как на некую стандартизированную монолитность уступает место более широкому и неоднозначному пониманию. Отмечается важная роль творчества А. Фолленвейдера в художественном пространстве СССР и России. Показано отражение в его работах перекрестных связей исторических событий и личной судьбы; принципы формирования языка, окрашенного романтизмом, метафорикой, лирикой, декоративностью колорита и конструктивностью формы.
The article is devoted to the artist and teacher of the Ural city of Korkino Arthur Vollenweider, whose legacy has recently become the object of art history and cultural studies. The main stages of the artist's biography and creative development are shown. The authors emphasize that the actualization of the Soviet heritage in regional variations is becoming a research mainstream, since the view of the art of socialist realism as a kind of standardized solidity is giving way to a broader and more ambiguous understanding. The important role of A. Vollenweider's creativity in the artistic space of the USSR and Russia is noted. The reflection in his works of cross-links of historical events and personal fate is shown; the principles of the formation of a language colored by romanticism, metaphor, lyricism, decorative coloring and constructive form.
Ural history in the monumental sculpture of Nizhny Tagil: universal and individual in the art of Tagil sculptors
Authors: Шемякина А.Л. 
Published: April 2022

Вехи развития советского государства нашли отражение в тагильской монументалистике, имея свои особенности. За время советской власти сложился определенный образ Нижнего Тагила как города труженика, поддерживаемый местными скульпторами. В то же время искусство Нижнего Тагила в 1920–1980-е годы развивалось в контексте тенденций и идеологических требований, характерных для всей страны в целом. Выявление типических, универсальных и индивидуальных черт в искусстве тагильских монументалистов — основная цель данного исследования.
Milestones in the development of the Soviet state are reflected in the Tagil muralist, having their own characteristics. During the Soviet period, a certain image of Nizhny Tagil as a city of workers was formed, supported by local sculptors, at the same time, the art of Nizhny Tagil developed all the years of Soviet power in the context of those trends and ideological requirements characteristic of the whole country as a whole. The identification of typical, universal and individual features in the art of Tagil muralists is the main purpose of this study.
Tanggungjawab Negara Terhadap Kebebasan Di Papua Sebagai Hak Asasi Manusia “Persfektif Kitab Suci Dan Teori Kebebasan”
Authors: Tekege Petrus 
Published: April 2022

Tujuan Penulisan dalam artikel ini adalah untuk mengaanalis dan mengemukakan apa kata Kitab Cuci dan apa kata Teori tentang kebebasan manusia dan bagaimana Negara berperan melaksanakan kewajiban pokoknya sebagai organisasi kekuasaan tertinggi dalam menegakkan Hukum dan HAM. Dalam kenyataanya Negara belum berperan maksimal dalam melindungi, menghormati dan memenuhi hak dasar setiap manusia karena terlihat disana-sini begitu banyak pelanggaran HAM terjadi dan belum terselesaikan seperti di Papua pada kabupaten Nguga, Intan Jaya, Puncak Jaya dan pelanggaran HAM masa lalu seperti Wasior Tahun 2001, Wamena Tahun 2003 dan Paniai tahun 2014. Agar harkat dan martabat manusia dijungjung tinggi maka Negara diharapkan berperan kongkrit untuk menyelesaikan berbagai pelanggaran HAM sesuai hukum yang berlaku dengan menempatkan nilai, harkat dan martabat setiap manusia sebagai ciptaan Tuhan diatas kekuasaan Negara dan kekuasaan Negara harus dipakai untuk melindungi, menghormati dan memenuhi kebutuhan setiap warga Negara sesuai amanah Kitab suci dan dasar hukum kodrat yang ada dalam mengembang kebebasan ekspresia orang Papua sebagai bagian dari Indonesia.
PRACTICAL DIAGNOSTIC LABORATORY TESTS FOR COVID-19 IN THE EMERGENCY DEPARTMENT
Authors: Aksu Esra Arslan 
Published: April 2022

<p>COVID-19 is an infectious disease caused by the SARS-Cov-2, and it was first reported in Wuhan province of China. RT-PCR test for viral nucleic acids in the diagnosis of COVID-19 is the gold standard method. However, when the number of patients admitted to the emergency department is too high, it may take a long time to result in the PCR test. In areas where suspicious cases are followed in isolation, possible PCR negative cases are also at risk. In the study, the data of patients who were admitted to the emergency department of Samsun Training and Research Hospital with the suspicion of COVID-19 in the years 2020-2021 were analyzed retrospectively. Laboratory and chest CT images were examined through the hospital's information processing system. The C-Reactive Protein (CRP), D-dimer, White Blood Cell (WBC) count, and Eosinophil count of the patients admitted as suspicious cases were evaluated. Chest CT images were evaluated according to the CO-RADS classification. A statistically significant difference was found between PCR positive and negative patients in terms of eosinophil count, CRP, d-dimer and CO-RADS classification. In our study, tests were evaluated at the stage of making a faster and more accurate diagnosis. In addition, the patient group included in our study is a specific group of patients who did not receive any medical treatment that could affect the results of the examination. As a result, when our study and previous studies are evaluated, CRP, d-dimer, eosinophil count and computerized tomography are the tests that can be used in the diagnosis of COVID-19. And examinations can be used in units where rapid diagnosis is required, such as emergency services.</p><p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0934/a.php" alt="Hit counter" /></p>