bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neutrophil extracellular traps exacerbate microglia/macrophages-mediated neuroinflammation via cGAS in mice with traumatic brain injury
Authors: shi mingming , Liu Liang , Cao Yiyao , Min Xiaobin , li tuo , Jia Haoran , Mi Liang , Zhang Yanfeng , Liu Xilei , Zhou Yuan , Li Shenghui , Yang Guili , Liu Xiao , Deng Quanjun , Chen Fanglian , chen xin , Zhang Shu , Zhang Jianning 
Published: November 2022

Abstract
Intense neuroinflammatory response with widespread microglia/macrophage activation and leucocyte infiltration occurring during the acute phase of traumatic brain injury (TBI) is an important mediator of secondary neurological injury. Neutrophils, as the most abundant leukocytes in peripheral circulation and the first-line transmigrated immune cells at the contused parenchyma following TBI, are suggested to worsen TBI outcomes and exacerbate TBI-related neuroinflammation, via unclear mechanisms. We hypothesized that neutrophil extracellular trap (NET) formation as a key mechanistic regulator, exacerbate microglia/macrophage-mediated neuroinflammation and acute neurological deficits after TBI. In this study, we observed massive NET formation in contused brain tissue of TBI patients and elevated plasma NET biomarkers correlated with upregulated cGAS-STING pathway. Overexpression of peptidylarginine deiminase 4 (PAD4) induces an increase in the NET formation that is accompanied by upregulation of the cGAS-STING pathway and exacerbation of microglia/macrophages-mediated neuroinflammation and neurological injury. Additionally, degradation of NETs-associated DNA by DNase 1 and inhibition of NET formation by pharmacological inhibition of PAD effectively inhibit cGAS-STING pathway activation and ameliorate microglia/macrophages-mediated neuroinflammatory responses. Collectively, our data highlight that targeting NETs is a promising therapeutic strategy for TBI treatment.
Why does mere field of study mismatch yield wage premium in the Turkish labor market?
Authors: EGE Ahmet Alper , ERDIL Erkan 
Published: November 2022

Abstract

Using a micro dataset from labor force survey of Turkey, this paper estimates the effects of covariates on wages by employing a quantile regression method, with special emphasis on the effect of overlapping mismatch. The analyses are conducted separately for two target groups: the employees who graduated from (i) higher education and (ii) vocational and technical high schools. For both target groups, employees who are well-matched by field of study but overeducated (mere vertical mismatch) and those who are both overeducated and mismatched by field of study (full-mismatch) incur wage penalties at an increasing rate along the wage distribution. However, for higher education, the effect of mere field of study mismatch (well-matched by education level but mismatched by field of study) on wages is mixed and novel to some extent in the literature. More notably, employees who graduated from higher education and who are merely field of study mismatched incur wage penalties at the first three quantiles of wage distribution but earn more than the well-matched employees at higher quantiles. This finding suggests that mere field of study mismatch need not be considered negative per se but it yields a wage premium, especially at higher quantiles of the wage distribution. This novel finding might imply that these employees are highly skilled and are preferred by employers with a reward of higher wages.
Development and verification of pyroptosis scoring system of lower-grade gliomas
Authors: Chen Xiao , Xu Ying , Wang Maode , Ren Chunying 
Published: November 2022

Abstract

Pyroptosis plays a crucial role in the malignant progression of solid tumors, while the underlying mechanism of pyroptosis has not been systematically investigated in lower-grade glioma (LGG). We retrospectively enrolled TCGA-LGG and CGGA-LGG cohorts, the Genotype-Tissue Expression project, and clinical samples. Pyroptosis-related genes (PRGs) were obtained from the Molecular Signatures Databas. Pyroptosis consensus clustering based on the expression profile of PRGs was used for consistency matrix construction in LGG samples. Subsequently, the “Boruta” algorithm was performed to identify the signature genes among pyroptosis subtypes. Principal component analysis implemented the dimension reduction of the expression profile of signature genes to construct a pyroptosis scoring system. Functional annotation analysis and immune cell infiltrating research depict the immune landscape among different pyroptosis groups. In addition, biomarkers of the pyroptosis scoring system were identified through weight gene co-expression network analysis (WGCNA). 27 PRGs were obtained, 5 of PRGS downregulate while 8 upregulate in LGG. Three pyroptosis patterns identified retain distinct clinical features and tumor microenvironment (TME). Based on the best cut-off pyroptosis value (7.244834), LGG samples were assigned into low and high pyroptosis groups. Patients with higher pyroptosis scores tend to have better prognoses. The pyroptosis score was considered as an indicator predicting the benefits of immunotherapy. In addition, BUB1 and KIF11 were considered the prognostic and pyroptosis-related markers in LGG. The Pyroptosis scoring system constructed in this study could heighten our comprehension of the tumor microenvironment of LGG and assist us in making individualized treatment strategies for patients.
Framing a novel holistic energy subsystem structure for water-energy-food nexus: A review of existing literature
Authors: Vahabzadeh Masoud , Afshar Abbas , Molajou Amir 
Published: November 2022

Abstract
Water, Energy, and Food (WEF) are inseparably interrelated vital resources for every society's subsistence, sustainability, and development. Due to world population growth and economic developments, new environmental challenges that aggravate WEF resources' insufficiency have emerged. WEF nexus aims to examine how three WEF subsystems will interact and grow together. Most existing energy models do not fully account for all requirements and interactions between the WEF subsystems in the WEF nexus context. This paper frames a comprehensive structure for the energy subsystem within the WEF nexus system for Iran country. In the proposed framework, the energy subsystem's supply and demand side are formulated using both data and equations. The presented framework addresses most interactions between WEF subsystems in a dynamic and adaptive setting. It is shown that through analysis of binding interactions between WEF, different management scenarios can boost the flexibility of the supply and demand side of the energy subsystem. In addition, by incorporating this framework, the water subsystem will manage the allocated and consumed water on the supply side and arrive at the most desirable outcome for the water sector. Also, the optimal cropping pattern could be evaluated based on energy consumption.
Importance of engineering geology on slope stability analysis applied in Northern Marmara Motorway (Section-5), İzmit, Turkey
Authors: Çakıner Müge , Bozkurtoğlu Erkan 
Published: November 2022

Abstract

Northern Marmara Motorway is a project planned to reduce the heavy traffic load around İstanbul, Tekirdağ, Kocaeli and Adapazarı provinces. In the Kurtköy-Akyazı section of the Northern Marmara Motorway, within the 5th section, bordered by “the Motorway Port Connection Road” and “İzmit Junction”, flow and slide-type mass movements were observed along the route. Possible causes of these mass movements occurred in the Çaycuma Formation which is sandstone-shale alternation, and the support system to stop the movements were evaluated within the scope of the study. The existing project criteria were analysed for the static and dynamic conditions, types of mass movements and the factors causing these mass movements were determined, and the slope stabilization applications suggested. The study area was additionally evaluated in terms of hydrogeological characteristics. Therefore, a meteorological water budget for the study area has been calculated by the Penman Method. Additionally, the water budget data was evaluated in terms of the mechanism that creates the mass movement, the environmental properties and the water relationships. Stability analyses were run in terms of soil structure, soil-rock mechanics, engineering geology, geotechnical engineering, and field and laboratory test results for the mass movements that took place in the right cut slopes between KM: 170 + 300 − 170 + 400, KM: 170 + 640 and KM: 175 + 297 − 175 + 463 of the 5th section.
Schistosoma mansoni excretory secretory products induce protein kinase signalling, hyperkinesis, and stem cell proliferation in the opposite sex
Authors: Shakir Eman , Rinaldi Gabirel , Kirk Ruth , Walker Anthony 
Published: November 2022

Abstract
Adult male and female schistosomes in copula dwell within human blood vessels and lay eggs that cause the major Neglected Tropical Disease human schistosomiasis. How males and females communicate to each other is poorly understood; however, male-female physical interaction is known to be important. Here, we investigated whether excretory-secretory products (ESPs), released into the external milieu by mature Schistosoma mansoni, might induce responses in the opposite sex. We demonstrate that ESPs adhere to the surface of opposite sex worms inducing the activation of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (p38 MAPK) pathways, particularly in the parasite tegument. Furthermore, we show that mature worms stimulated signalling in juvenile worms. Strikingly, we demonstrate that ESPs from the opposite sex promote stem cell proliferation, in an ERK- and p38 MAPK-dependent manner, in the tegument and within the testes of males, and the ovaries and vitellaria of females. Hyperkinesia also occurred following opposite sex ESP exposure. Our findings support the novel concept that male and female schistosomes may communicate over distance to modulate key processes underlying worm development and disease progression, opening novel avenues for schistosomiasis control.
The effect of northern hemisphere blocking systems on wet and dry periods in Iran under climate change conditions
Authors: Nejad Meysam Toulabi , Sharifi Leyla , Lupo Anthony R 
Published: November 2022

Abstract

The present research was carried with the aim of investigating the relationship between blockings in the northern hemisphere and widespread wet periods and droughts in Iran. The data of the research include: precipitation of 43 synoptic stations of Iran, data of 500 hPa height geopotential and blocking factors from 1973 up to 2018. Blocking indicator (BI) was used for studying blockings and ZSI indicator was used to extract wet periods and droughts. Pearson's correlation was also used to investigate the relationship between blocking components and droughts and wet periods. Results from investigating widespread wet periods and droughts showed that before global warming, 7 wet periods occurred broadly while during the global warming, this number decreased to 5 years. Nevertheless, widespread droughts increased from 16 years to 18 years. Results from data analysis reveals that during a 46-year period of time, 977 blocking's cores have been shaped in the whole region 41 percent of which have been formed in pre-climate change period and the rest 59 percent in the second period. Regarding the intensity of blocking'sformation, it can be said that more than 77% of blockings have been medium, 10.5 % strong and 12% have been weak and with the occurrence of global warming got even weaker and inclined more to dryness and latitudes above 55 55º N. As a result, their power has decreased and they reached Iran less effectively. Blockings migration to upper latitudes can be attributed to the Increase in the subtropical high-pressure force and reduction of polar vortex penetration (polar low pressure) toward middle latitudes due to climate change. Thus, with the transference of blocking cores to upper latitudes the landing position of the troughs resulted from the blocking systems, has lesser reached to Iran and as a result, drought in Iran has increased. The results from correlation of factors of blocking and wet periods and droughts showed that in the situation of climate change, the intensity of blocking systems affecting Iran has decreased and led to decrease of wet periods and increase of droughts.
Incidence and Predictors of Acute Kidney Injury Among Type 2 Diabetes Mellitus Patients in Amhara Region Comprehensive Specialized Hospitals, 2021: Retrospective Follow-up Study
Authors: Abiye Melesse , Gedefaw Mihrete , Endaweke Migbaru , Abinew Yideg , Shimekaw Atirsaw , Gurmu Yonas , Zeleke Haymanot 
Published: November 2022

Abstract
Background
- Acute kidney injury is an emerging global public health problem significantly associated with increased in morbidity, mortality, and extra cost incurred. Type 2 diabetes mellitus is an independent risk factor for acute kidney injury that is not well investigated in developing countries including Ethiopia.
Objective
- To assess the incidence and predictors of acute kidney injury among type 2 diabetes mellitus patients having follow-ups in Amhara region Comprehensive Specialized Hospitals.
Methods
- Institution-based retrospective follow-up study was conducted among 538 type 2 diabetes mellitus patients from January 1, 2014, to January 1, 2020, by systematic random sampling. Kaplan-Meier curve and Log-rank test were used to compare survival time between different categories of explanatory variables. Cox proportional hazard was used to determine significant predictors and proportional hazard assumptions were checked by plotting cox Snell’s residual and global test.
Results
- the incidence rate of acute kidney injury among type 2 diabetes mellitus patients was 38 per 10,000 person-months observations. The significant predictors were poor glycemic control [AHR (95% CI) 1.70(1.06, 2.74)], Hypertension [AHR (95% CI) 2.36(1.17, 4.79)], Congestive heart failure [AHR (95% CI) 1.79(1.11, 2.89)], Chronic kidney disease [AHR (95% CI) 2.02(1.23, 3.33)], Dyslipidemia [AHR (95% CI) 2.57(1.40, 4.70)], Diabetic nephropathy [AHR (95% CI) 2.08(1.24, 3.51)], Sepsis [AHR (95% CI) 2.96(1.87, 4.70)] and Body mass index((> 30 & 25-29.9 kg/m2); [AHR (95% CI) 4.24(1.98, 9.07) and 2.84(1.50, 5.38) respectively)].
Conclusion
- the incidence of acute kidney injury among type 2 diabetes mellitus patients was relatively higher in this study area than in previous studies. Implementing good glycemic control, close monitoring of comorbidities, infection prevention, and weight reduction were vital to reducing the incidence of acute kidney injury in type 2 diabetic patients.
Faecal microbiota transplantation from Alzheimer’s participants induces impairments in hippocampal neurogenesis and cognitive behaviours in rats
Authors: Grabrucker Stefanie , Marizzoni Moira , Silajdžić Edina , Lopizzo Nicolo , Mombelli Elisa , Nicolas Sarah , Dohm-Hansen Sebastian , Scassellati Catia , Moretti Davide , Rosa Melissa , Hoffmann Karina , Englsih Jane , Lavelle Aonghus , O'Neill Cora , Thuret Sandrine , Cattaneo Annamaria , Nolan Yvonne 
Published: November 2022

Abstract
The gut microbiome is emerging as an important susceptibility factor in Alzheimer’s disease (AD) possibly due to the increased prevalence of pro-inflammatory genera in gut microbiota of AD participants. Microbiota-mediated changes in cognition and adult hippocampal neurogenesis (AHN), an important process for memory which is altered in AD, position the microbiota-gut-brain axis as a key regulator of AD. However, it is unknown whether gut microbiota alterations are the cause or consequence of AD symptoms. We transplanted faecal microbiota from AD participants and age-matched controls into microbiota-depleted naïve adult rats and found impairments in AHN and associated memory tasks, which correlated with clinical cognitive scores. Discrete changes in the rat caecal and hippocampal metabolome were evident. Serum from AD participants also decreased neurogenesis in vitro and correlated with cognitive scores and pro-inflammatory genera. Our results reveal that the cognitive symptoms in AD may be due to alterations in gut microbiota, and that impaired neurogenesis may be a mechanistic link between altered gut microbiota and cognitive impairment in AD.
Label-free aptasensor for the ultrasensitive detection of insulin via a synergistic fluorescent turn-on strategy based on G-quadruplex and AIEgens
Authors: Zeng Xiaohui , Wang Hailong , Zeng Yanbo , Yang Yiwen , Zhang Zulei , Li Lei 
Published: November 2022

Abstract

Insulin, the only hormone regulating blood glucose level, is strongly associated with diabetes and its complications. Specific recognition and ultrasensitive detection of insulin are of clinical significance for the early diagnosis and treatment of diabetes. Inspired by aggregation-induced emission, we presented a turn-on label-free fluorescence aptasensor for insulin detection. Quaternized tetraphenylethene salt was synthesized as the fluorescence probe, guanine-rich aptamer IGA3 was selected as recognition element, and graphene oxide was chosen as the quencher. Under optimized conditions, the fluorescence aptasensor displayed a wide linear range (1.0 pM–1.0 µM) with a low limit of detection (0.42 pM). Furthermore, the aptasensor was successfully applied to detect insulin in human serum. Spiked recoveries were obtained in the range of 96.06–104.26%. All these results demonstrated that the proposed approach has potential application in the clinical diagnostics of diabetes.
Presaccadic attention sharpens visual acuity
Authors: Kwak Yuna , Hanning Nina M. , Carrasco Marisa 
Published: November 2022

Abstract
Visual perception is limited by spatial resolution, the ability to discriminate fine details. Spatial resolution not only declines with eccentricity but also differs for polar angle locations around the visual field, also known as ‘performance fields'. To compensate for poor peripheral resolution, we make rapid eye movements –saccades– to bring peripheral objects into high-acuity foveal vision. Already before saccade onset, visual attention shifts to the saccade target location and prioritizes visual processing. This presaccadic shift of attention improves performance in many visual tasks, but whether it changes resolution is unknown. Here, we investigated whether presaccadic attention sharpens peripheral spatial resolution; and if so, whether such effect interacts with performance fields asymmetries. We measured acuity thresholds in an orientation discrimination task during fixation and saccade preparation around the visual field. The results revealed that presaccadic attention sharpens acuity, which can facilitate a smooth transition from peripheral to foveal representation. This acuity enhancement is similar across the four cardinal locations; thus, the typically robust effect of presaccadic attention does not change polar angle differences in resolution.
Adaptive Reduced Parameters Fault-Tolerant Tracking Control for Stochastic Multiagent Systems with Simplifified Memory Event-Triggered Strategy
Authors: Li Dongni , Cao Liang , Xue Hong 
Published: November 2022

Abstract
The memory event-triggered finite-time bipartite tracking control scheme is presented for the stochastic nonlinear multiagent systems (MASs). The actuator is affected by Bouc-Wen Hysteresis and actuator faults simultaneously, and to guarantee the tracking performance, an adaptive finite-time bipartite controller which reduces online estimation parameters is constructed for the stochastic systems. A simplified memory event-triggered mechanism is proposed under the backstepping framework for the first time. Furthermore, the released data is used to set the event-triggered threshold condition, which avoids the problem of trigger instability caused by actuator faults and Bouc-Wen Hysteresis. Disturbance observers are applied to compensate the impact of input hysteresis and system disturbances. According to the Lyapunov theory, it is shown that all signals of the closed-loop systems are semiglobal practical finite-time stable (SGPFS) in probability. Meanwhile, the bipartite control performance is obtained. Finally, a practical and a numerical simulation example are provided to attest the validity of the proposed bipartite tracking control strategy.
Correlation and Agreement Between Arterial and Venous Blood Gas Analysis in Patients with Hypotension - An Emergency Department Based Cross Sectional Study
Authors: Prasad Hari , Vempalli Nagasubramanyam , Agrawal Naman , N Ajun U , Salam Ajmal , Datta Soumya Subhra , Singhal Ashutosh , Ranjan Nishant , P Shabeeba Sherin P , G Sundareshan 
Published: November 2022

Abstract
Background
Blood gas analysis is integral to assessing emergency department (ED) patients with acute respiratory or metabolic disease. Arterial blood gas (ABG) is the gold standard for oxygenation, ventilation, and acid-base status but is painful to obtain. Peripheral venous blood gas (VBG) is a valuable alternative as it is less painful and easy to collect. The comparability of ABG and VBG was studied in various conditions. But in hypotension, comparability is still a concern. So, we studied the correlation and agreement between ABG and VBG in hypotensive patients.
Methodology:
The study was conducted at the emergency department of a tertiary healthcare center in Northern India. Patients with hypotension above 18 years of age who satisfied the inclusion criteria were clinically evaluated. Patients who require ABG as a part of routine care were sampled. ABG was collected from the radial artery at the wrist level. VBG was obtained from the cubital or dorsal hand veins. Both samples were collected within 10 minutes and were analyzed. All ABG and VBG variables were entered in premade proforma. The patient was then treated and disposed of according to institutional protocol.
Results
Two hundred fifty patients were enrolled. The mean age was 53.25 ± 15.71 years. 56.8% were male. The study included 45.6% septic, 34.4% hypovolemic, 18% cardiogenic, and 2% obstructive shock patients. The study found a strong correlation and agreement for ABG and VBG pH, pCO2, HCO3, lactate, sodium, potassium, chloride, ionized calcium, blood urea nitrogen, base excess, and arterial/alveolar oxygen ratio. Hence, regression equations were made for the aforementioned. There was no correlation observed between ABG and VBG pO2 and SpO2. Our study concluded that VBG could be a reasonable alternative for ABG in hypotensive patients. We can also mathematically predict values of ABG from VBG using regression equations derived.
Conclusions
The study has shown strong correlations and agreements for most ABG and VBG parameters except pO2 and SO2. The study can predict an ABG mathematically using regression formulas formulated from a VBG. This will decrease needle stick injury, consume less time, and make blood gas evaluation easy in hypotensive settings.