bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why Is Friday Better than Sunday?
Authors: Da Silva Sergio , Matsushita Raul , Korzenowski Eduarda 
Published: March 2022

We present survey evidence that most people prefer Friday to Sunday. Moreover, we pit against one another two explanations for this fact, the joy of anticipation hypothesis and the Weber law. According to the joy of anticipation hypothesis, Friday promises a weekend ahead, and Sunday does not. The Weber law predicts a relative decrease in the perception of interesting new events as the weekend passes, contributing to the impression that time is shortened as Sunday comes. Our findings favour the joy of anticipation hypothesis. JEL: D91, D15
Blood volume estimation in cardiac surgery – A comparative analysis
Authors: Cumpston Philip 
Published: March 2022

Introduction This paper seeks to identify which of three published formulas used for estimating the blood volume of normal human subjects correlates most closely with blood volumes measured in a published study where erythrocyte volume was determined by a method using 51Cr and a nonradioactive dye was used to determine the plasma volume. Methods Blood volumes predicted by three published algorithms were compared with blood volume estimates from a study by Retzlaff et al. using the two-tailed Wilcoxon signed rank test and a robust version of the Bland–Altman test. Results When applied to a sample of normal subjects selected from Mayo Clinic personnel and patients, the Nadler formula correlated more closely with blood volume measured using a radio nucleotide technique than did the Allen formula or one based on a saline haemodilution technique. Conclusions The Nadler formula correlated more closely with blood volume measurements derived from Retzlaff’s study than the other formulas for estimating blood volume in a population with height and weight distribution more consistent with that seen in North America. It should be used in preference to the Allen formula for estimating blood volume in adult patients currently undergoing cardiac surgical procedures. Saline haemodilution techniques used to measure blood volume require validation against more recently developed nuclear medicine techniques using statistical methods other than regression analysis. Until validated, they should be used with caution for estimating blood volume in adult patients currently undergoing cardiac surgical procedures. If a formula using height, weight and sex is used to estimate blood volume in the context of cardiac surgery, then it must be derived using a much more comprehensive sample of the population to which it is applied than has occurred to date. In particular, it should include broader distributions of height, weight and the presence or absence and type of significant valvular disease.
Effects of different exercise methods of calf muscles on the hemodynamics of lower extremity vein
Authors: Li Tianhua , Yang Shuhong , Dou Chenhao , Geng Qian , Lu Qing , Hu Fang , Ding Junqin 
Published: March 2022

Objective To compare the effects of active and passive calf muscle contraction on the hemodynamics of the lower extremity vein. Methods 30 females were selected by convenient sampling. The hemodynamic indexes of the common femoral vein were measured by Duplex ultrasound during the active ankle pump exercise, active circular exercise, passive ankle pump exercise, passive circular exercise, and massage the calf muscles. Results There was no significant difference in the velocity of common femoral vein when the subjects do active ankle pump exercise, active circular exercise, and massage the calf muscles ( p > .05), but the velocity of common femoral vein was faster than that of passive ankle pump exercise and passive circular exercise ( p < .01). Conclusion The effects of active ankle exercise and massage on promoting venous blood return of lower extremity are better than that of passive ankle exercise.
Correlation between characteristics of intracranial atherosclerotic plaques and ischemic stroke in high-resolution vascular wall MRI
Authors: Sun Jie , Feng Xu-Ran , Yang Xuan , Feng Ping-Yong , Liu Yu-Bo , Yang Hai-Xiao , Zhang Tian-Zi 
Published: March 2022

Background Intracranial atherosclerotic stenosis is a major cause of ischemic stroke, accounting for 30% of ischemic strokes in Asian populations. Purpose To investigate the relationship between the degree of arterial stenosis and enhancement grade of intracranial atherosclerotic disease (ICAD), the plaque characteristics in different remodeling patterns, and its potential impact. Material and Methods A total of 210 patients diagnosed with ICAD were enrolled in this retrospective study. Patients were divided into the middle cerebral artery (MCA) group (101 cases), posterior cerebral artery (PCA) group (14 cases), basilar artery (BA) group (71 cases), and intracranial segment of vertebral artery (VA) group (90 cases) according to the difference of diseased vessels. Data on presence or absence of ischemic infarction, intracranial vascular position of lesions, plaque characteristics, ICAD enhancement grade, remodeling index, and degree of arterial stenosis were collected for analysis. Results The incidence of ischemic infarction in enhancement grade 2 was significantly higher than that in enhancement grade 1 in MCA group ( P = 0.019). Enhancement grade 2 of ICAD was an independent risk factor for the development of ischemic infarction (odds ratio = 4.60; 95% confidence interval: 1.91–11.03; P = 0.001). There was no significant statistical difference in infarct rate between different remodeling modalities ( P>0.05). Conclusion Enhancement grade of ICAD is significantly associated with the degree of stenosis and the occurrence of ischemic stroke, which varies in different intracranial vessels. The pattern of vascular remodeling varies among different intracranial vessels, and the pattern of vascular remodeling has a significant impact on plaque characteristics.
Prevalence of elevated Anti-p53 in Chinese patients with upper gastrointestinal or colorectal cancer
Authors: Wang Min , Xie Suhong , Gao Xiang , Feng Jingjing , Deng Minjie , Sun Jiajun , He Ying , Donner Horst , Lu Renqun , Guo Lin 
Published: March 2022

Background The monitoring of anti-p53 auto-antibodies in the peripheral blood has been used in cancer management; however, their clinical significance alone is limited. This pilot study aimed to describe the prevalence of elevated anti-p53 in newly diagnosed or recurrent upper gastrointestinal cancer or colorectal cancer in Chinese subjects. It also evaluated whether the addition of anti-p53 to a set of established tumor markers would allow for the detection of additional cancer cases than when using these markers alone. Methods A total of 573 subjects, including 187 healthy individuals, 169 patients with upper gastrointestinal cancer and 217 patients with colorectal cancer were included in this observational, prospective study. All subjects were required to provide up to 10 mL of blood. The following biomarkers were measured: anti-p53, carcinoembryonic antigen, cancer antigen (CA)19-9, and CA72-4. Results At the cutoff of 0.02 µg/mL, the sensitivity of anti-p53 in early-stage upper gastrointestinal cancer and colorectal cancer was 8.16% and 26.4%, and in late-stage disease was 7.81 and 28.0%, respectively. The specificity of anti-p53 in the healthy cohort at this cutoff was 98.4%. By adding anti-p53 to other tumor markers, the sensitivities were increased by 8.88%–9.47% in upper gastrointestinal cancer, and by 18.06%–25.00% in colorectal cancer; specificities decreased by 1%–2%. Conclusion The addition of anti-p53 to established tumor markers may improve their diagnostic value for patients with colorectal cancer.
Preparation of polybutylene terephthalate/artificial marble wastes composites with simultaneously enhanced thermal, crystallization, and impact properties by in situ polymerization
Authors: Feng Tianliang , Li Yangzhou , Pang Yilan , Fang Liang , Chen Zhenming 
Published: March 2022

The treatment of artificial marble wastes (AMWs) is a difficult aspect of the artificial marble industry and has enormous impacts on the environment. Herein, a series of polybutylene terephthalate (PBT)/AMWs composites were prepared by in situ polymerization. The effects of AMWs content (1–10 wt%) on the thermal stability, crystallization rate, and impact strength of the PBT/AMWs composites were investigated in detail. The results showed that the composites containing 10 wt% of AMWs exhibited the best performance. Due to the high thermal resistance and uniform distribution of the AMWs particles, the heat deflection temperature reached 67.40°C with optimal thermal stability. Additionally, under heterogeneous nucleation, the crystallization rate was also the highest, and impact strength reached 17.29 kJ/m2 due to the partial core-shell structure and hardened matrix effects of the AMWs particles.
Safety and Tolerability of Intravenous Push Lacosamide and Levetiracetam
Authors: Ragoonanan David , Tran Nicolas , Levesque Melissa 
Published: March 2022

Background: Lacosamide and levetiracetam are antiseizure medications (ASMs) commonly utilized in the treatment and prevention of seizures. Historically, these agents have been administered as slow IV infusions after further dilution. Recent literature suggests that rapid administration via undiluted IV push may be safe and may increase efficiency of administration. Objective: This study aimed to evaluate the safety and tolerability of undiluted IV push lacosamide and levetiracetam over 5 min. Methods: This study was conducted as a single-centered, retrospective, observational cohort that analyzed the rapid administration of undiluted lacosamide and levetiracetam. Adult patients admitted from September 1st, 2019, to May 31st, 2020, receiving at least one administration of IV push lacosamide at any dose or levetiracetam at doses ≤ 1500 mg were evaluated. The primary safety outcomes were the incidence of hypotension and bradycardia. Results: A total of 86 subjects were evaluated; 36 patients were administered lacosamide, and 50 patients were administered levetiracetam. Hypotension or bradycardia occurred in 6 patients in the lacosamide group (16.6%) and 6 patients in the levetiracetam group (12.0%). There were no reported infusion site reactions. Among the subjects who received lacosamide and had a 12-lead electrocardiogram (EKG), there were no reported incidences of a prolonged PR interval. Conclusions: In this safety-analysis cohort, undiluted lacosamide and levetiracetam were not associated with significant adverse events when administered via IV push over 5 min. This seems to be a safe alternative method of administration to intermittent infusion. A larger, prospective cohort is needed to confirm these findings.
Calling the Shots: Determinants of Financial Decision-making and Behavior in Domestic Migrant Households in India
Authors: Kurian Vinith , Sreedharan Shashank , Valenti Fabrizio 
Published: March 2022

This article explores financial decision-making and behavior in migrant households. Literature on migration and financial inclusion usually focuses on either migrant workers and their financial needs or remittance flows and their effects on development, leaving the subject of household decision-making significantly underresearched. Using primary data from two sample surveys, one with migrant workers and one with their household members, we employ descriptive analysis to study the financial decision-making processes and outcomes. Our sample is mostly composed of male Indian domestic migrants from Bihar, Jharkhand, and eastern Uttar Pradesh. Our analysis considers the following migrant typology dimensions: duration of migration cycle, skills, and destination. Key household characteristics explored in our study include household size, the number of financial contributors in the household, the presence of an older male and children below the age of 18, and overall household income. Our results show that household members compete for influence over financial decisions and power balances change significantly whether the migrant is at home or at destination. These dynamics play an important role in determining household financial preferences. This suggests that financial products and interventions targeting specific financial behavior (for instance, financial literacy programs) need to take these factors into account since different households and different migrant types make these choices differently. JEL Codes: D14, O15, O16
Virtual Regions Strategy for Development of Tribal Communities
Authors: Kulkarni Kiran , Shivagunde Sonal 
Published: March 2022

The Scheduled Tribe (ST) population in India is one of the most marginalised and deprived one in the country. The Constitution of India itself mandates exclusive approach, strategies and measures for their development. The Government of India and the state governments, along with other key stakeholders, have been taking very specific policy and programmatic interventions for reducing the disparities between the ST and other social groups for the past 74 years. The impact of these measures is clearly reflected through the improvement in vital development indicators. However, several gaps and challenges continue to persist, implying revisiting the fundamental approaches and planning processes which direct the interventions at policy and implementation level. In this article, an alternative, more focussed approach of ‘virtual region as planning unit’ takes the aspects related to geographical, cultural and developmental heterogeneity into consideration. Concrete strategies for implementation of various policies and programmes adopting the approach of virtual region planning in light of challenges have been presented. JEL Classification: D63, H11, H53, H61, H72, H75, H83, I14, I25, I38, J15, O21, O43, Y10, Z18
Effect of surgery and radiotherapy on overall survival in patients with chondrosarcoma: A SEER-based study
Authors: Wang Miao , Song Yu , Liu Shengfu , Sun Weibing 
Published: March 2022

Purpose Chondrosarcoma is an orthopedic malignancy, and the purpose of this study was to evaluate the effect of surgery and radiotherapy (RT) on the survival of patients with chondrosarcoma. Methods Data were obtained from the SEER database for patients diagnosed with chondrosarcoma between 1988 and 2015. All patients were divided into surgery, RT, surgery + RT, and no surgery/no RT groups. Kaplan–Meier curves were used to analyze the overall survival and cancer-specific survival of patients in different treatment groups. The propensity score matching was used to balance baseline covariates between patients in the surgery and surgery + RT groups and in the RT and surgery + RT groups. Results Data from 3756 patients with chondrosarcoma were included in this study. The number of patients who underwent surgery, RT, surgery + RT, and no surgery or RT was 2885 (76.8%), 112 (3.0%), 403 (10.7%), and 356 (9.5%), respectively. Multivariate Cox regression models showed that treatment modality was independent risk factor for OS and CSS. Before PSM, Kaplan–Meier curves showed that OS and CSS were highest in the surgery group and lowest in the RT group. After PSM, although there was no significant difference in OS ( p = .13) and CSS ( p = .22) between the surgery and surgery + RT group, OS was longer in the surgery group than in the surgery + RT group. Additionally, OS ( p < .001) and CSS ( p = .009) were longer in the surgery + RT group than in the RT group after PSM. Conclusion Surgical resection was the key approach for the treatment of chondrosarcoma, while RT confers no significant advantage in improving patient survival time.
Correlation of Epidermal Growth Factor Receptor Mutation With Major Histologic Subtype of Lung Adenocarcinoma According to IASLC/ATS/ERS Classification
Authors: Boukansa Sara , Benbrahim Zineb , Gamrani Sanaa , Bardai Sanae , Bouguenouch Laila , Mazti Asmae , Boutahiri Nadia , Serraj Mounia , Amara Bouchra , Ouadnouni Yassine , Smahi Mohamed , Alami Badreeddine , Mellas Nawfel , El Fatemi Hinde 
Published: March 2022

Objective Our prospective study aims to define the correlation of EGFR(epidermal growth factor receptor) mutations with major histological subtypes of lung adenocarcinoma from resected and non-resected specimens, according to the WHO 2015 classification, in Moroccan North East Population. Methods Epidermal growth factor receptor mutations of 150 primary lung adenocarcinoma were performed using Real-Time PCR or SANGER sequencing. SPSS 21 was used to assess the relationship between histological subtypes of lung adenocarcinoma and EGFR mutation status. Results 25 mutations were detected in the series of 150 lung adenocarcinomas, most of which were found in cases with papillary, acinar, patterns than without these patterns and more frequently occurred in the cases without solid pattern than with this pattern. A significant correlation was observed between EGFR mutation and acinar (P = 0,024), papillary pattern (P = 0,003) and, negative association with a solid pattern (P < 0,001). In females, EGFR mutations were significantly correlated with the acinar pattern (P = 0,02), whereas in males with the papillary pattern (P = 0,01). Association between the histologic component and exon 19 deletions and exon 21 mutations were also evaluated and, we found a significant correlation between the papillary major pattern with exon 19 mutations (P = 0,004) and, ex21 with the acinar component (P = 0,03). Conclusion An analysis of resected and non-resected lung ADC specimens in 150 Moroccan Northeast patients, revealed that acinar and papillary patterns may predict the presence of a mutation in the EGFR gene. While the solid major pattern may indicate a low mutation rate of the EGFR gene.
Management of bilateral conjunctival squamous carcinoma following ocular cicatricial pemphigoid: A case report and review of literature
Authors: Franco Elena , Salgari Niccolò , Dugo Marco , Franco Maria , Stefanelli Antonio , Franco Filippo 
Published: March 2022

The purpose of this study is to report a case of bilateral highly locally invasive conjunctival squamous neoplasia in the clinical setting of ocular cicatricial pemphigoid (OCP), and to review the available literature about this rare association. Case description: A man presented with chronic bilateral conjunctivitis and forniceal foreshortening. He had been previously diagnosed with OCP, and received proper therapy with systemic Dapsone and local steroids. After six months from treatment initiation, the patient complained of worsening symptoms and underwent two more biopsies, revealing a bilateral conjunctival squamous neoplasia. Conclusion: In rare cases, OCP can be associated with conjunctival squamous neoplasia. In case of suspected clinical modifications, it is important to make an early diagnosis by repeating several conjunctival biopsies or by performing less invasive diagnostic techniques (e.g. impression cytology of the ocular surface epithelium) to avoid unnecessary surgical damages.
Retinal atrophy and markers of systemic and cerebrovascular severity in homozygous sickle cell disease
Authors: Martin Gilles C. , Brousse Valentine , Connes Philippe , Grevent David , Kossorotoff Manoelle , Da Costa Lydie , Bourdeau Hélène , Charlot Keyne , Boutonnat-Faucher Bénédicte , Allali Slimane , De Montalembert Mariane , Bremond-Gignac Dominique , Vidal Pierre-Paul , Robert Matthieu P. 
Published: March 2022

Introduction While paramacular retinal atrophy (PRA) is known to be found in 48% of eyes of adults and 42% of eyes of children with homozygous SCD (SS-SCD), the aim of this study is to assess the association between PRA and red blood cell (RBC) deformability, hematological markers and brain imaging abnormalities in SS-SCD. Methods This study is a subset of DREAM2, a prospective observational study performed between August 2015 and August 2016. Children (5–17 years) with SS-SCD and no history of large vessel vasculopathy, were included. Ophthalmological characteristics including visual acuity, fundus examination, OCT of central and temporal retina (with several retinal thickness measurements) were explored in relation with RBC deformability (ektacytometry), hematological and biochemical (hemolysis parameters), and neurological (cerebral oxygenation estimated by Near Infrared Spectroscopy, brain magnetic resonance imaging) investigations. Results 17 children (5 boys; mean age: 13 years) with complete ophthalmological investigations were included in the analysis; 8 exhibited PRA. RBC deformability was found to be significantly lower in children with PRA for measurements made at 1.69 Pa (0.16 a.u ± 0.02 vs 0.21 a.u ± 0.03, p = 0.02) and above, as well as cerebral oxygenation (59.25% ± 9.9 vs 71.53% ± 4.9, p = 0.02). A significant positive correlation was found between temporal retinal thickness and hemoglobin level (ρ = 0.65, p = 0.007), hematocrit (ρ = 0.53, p = 0.04) and RBC deformability at 3 Pa (ρ = 0.75, p = 0.005) and above. Conclusions These results suggest that PRA could be an early marker of systemic severity and cerebral oxygenation in SCD. Whether it could help predicting cerebral vasculopathy requires further investigations.
Does 18F-FDG PET/CT change the surgical management of potentially resectable colorectal liver metastases?
Authors: Jonsson Josefin , Hemmingsson Oskar , Strengbom Rebecca , Axelsson Jan , Riklund Katrine , Nyström Hanna 
Published: March 2022

Purpose: Resectability assessment of patients with colorectal liver metastases is based on computed tomography and liver magnetic resonance imaging. Addition of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography has been recommended, but the impact of the added information remains unclear. The primary aim of this study was to determine how preoperative positron emission tomography/computed tomography changed management in patients with potentially resectable colorectal liver metastases. The secondary aim was to investigate whether findings on positron emission tomography/computed tomography correlated to metastatic disease in cases with extended surgery and influenced oncological outcomes. Methods: A retrospective observational study of the impact of adding positron emission tomography/computed tomography to conventional imaging in the surgical decision-making of colorectal liver metastases. All patients with colorectal liver metastases diagnosed by conventional imaging were included and assessed by a multidisciplinary team conference at Umeå University Hospital between June 2013 and December 2017. Eligibility criteria were all patients with potentially resectable colorectal liver metastases. Patients who underwent preoperative positron emission tomography/computed tomography in addition to conventional radiology were compared with those who underwent conventional imaging only. Results: 151/220 patients underwent preoperative positron emission tomography/computed tomography. Findings on positron emission tomography/computed tomography changed the management in 10.6% of the patients. Eight patients were excluded from surgery after detection by positron emission tomography/computed tomography of extrahepatic disease. Eight patients underwent more extended surgery than initially planned due to positron emission tomography/computed tomography. Five of these positron emission tomography-positive resected sites were verified by pathology as metastatic disease. No difference in overall survival was seen following surgical resection in patients with and without a preoperative positron emission tomography/computed tomography. Conclusions: Preoperative positron emission tomography/computed tomography resulted in a changed surgical management in 10.6% of cases in a selected cohort.