bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-Hospital Availability of Instrumental Support May Influence Patients' Readiness for Discharge
Authors: Schultz Beth E. , Corbett Cynthia F. , Hughes Ronda G. , Bell Nathaniel 
Published: May 2022

Purpose of Study:
Evaluate the relationship between unplanned acute care utilization after discharge from an index hospital admission and registered nurse and patient perceptions of available instrumental support the patient would have after discharge.

Primary Practice Setting:
Three hospitals in a large regional hospital system in the southeastern United States.

Methodology and Sample:
Retrospective, secondary quantitative analysis of 13,361 patient records (mean age 58.4 years; 51% female) from index hospitalizations evaluating patient and nurse responses to 2 questions that specifically address instrumental support on both the patient and nurse versions of the Readiness for Hospital Discharge Survey (RHDS) and subsequent unexpected care received (emergency department [ED] visit, observation stay, hospital readmission) in the acute care setting within 60 days of discharge. Logistic regression was used to evaluate the relationship between RHDS scores and unplanned care received.

Results:
Patients who required hospital-based acute care within 60 days after discharge had lower average RN-RHDS scores than those who did not require hospital-based acute care.

Implications for Case Management Practice:
Including a nursing assessment of potential postdischarge expected instrumental support may be helpful in identifying patients who are at a higher risk of experiencing postdischarge acute care utilization. Monitoring ED visits and observation stays in addition to readmissions will facilitate capturing significantly more points of care received after discharge and provide additional information regarding postdischarge care utilization.
Parent-Reported Experience Measures of Care for Children With Serious Illnesses: A Scoping Review
Authors: Ang Felicia Jia Ler , Finkelstein Eric Andrew , Gandhi Mihir 
Published: May 2022

OBJECTIVE:
This scoping review aimed to: 1) identify parent-reported experience measures (PaREMs) for parents of children with serious illnesses from peer-reviewed literature, 2) map the types of care experience being evaluated in PaREMs, 3) identify and describe steps followed in the measure development process, including where gaps lie and how PaREMs may be improved in future efforts, and 4) help service providers choose a PaREM suitable for their service delivery setting and strategy.

DATA SOURCES:
Relevant articles were systematically searched from PubMed, CINAHL, and Scopus EBSCOhost databases until June 10, 2021, followed by a manual reference list search of highly relevant articles.

STUDY SELECTION:
Abstracts were screened, followed by a full-text review using predetermined inclusion and exclusion criteria.

DATA EXTRACTION:
A standardized data extraction tool was used.

DATA SYNTHESIS:
Sixteen PaREMs were identified. There were large variances in the development processes across measures, and most have been developed in high-income, English-speaking Western countries. Most only assess the quality of acute inpatient care. Few measures can be used by multiple service providers or chronic care, and many do not capture all relevant domains of the parent experience.

CONCLUSIONS:
Service providers should integrate PaREMs into their settings to track and improve the quality of care. Given the multidisciplinary nature of pediatric care and the often-unpredictable disease trajectories of seriously ill children, measures that are applicable to multiple providers and varying lengths of care are essential for standardized assessment of quality of care and coordination among providers. To improve future PaREM development, researchers should follow consistent and methodologically robust steps, ideally in more diverse sociocultural and health systems contexts. Future measures should widen their scope to be applicable over the disease trajectory and to multiple service providers in a child’s network of care for a comprehensive evaluation of experience.
Ultrasound-Guided Paravenous Saphenous Nerve Block for Lower Extremity Abscess Incision and Drainage in a Male Adolescent
Authors: Allen Kelsey W. , Moake Matthew M. 
Published: May 2022

Abstract
The use of ultrasound-guided regional anesthesia is growing as a modality for analgesia provision within the pediatric emergency department. We present a case in which a paravenous saphenous nerve block was used for anesthesia during incision and drainage of a lower extremity abscess. We further review the technique and literature concerning this straightforward and effective procedure.
The Outcomes of an Individualized Physical Therapy Program in CALFAN Syndrome: A Case Report
Authors: Yigit Sedat , Albayrak Hatice Mutlu , Perk Yücel Peren , Usgu Serkan , Yakut Yavuz 
Published: May 2022

Purpose:
This case report investigated the effectiveness of an individualized physical therapy program in CALFAN syndrome.

Case Description:
A 13-year-old girl participated in physical therapy, which included trunk stabilization, balance training, and functional exercises for 12 weeks.

Assessments:
The International Cooperative Ataxia Rating Scale; Trunk Impairment Scale; Pediatric Quality of Life Inventory; Functional Independence Measure for Children; Quick Disability of the Arm, Shoulder, and Hand Questionnaire; 9-Hole Peg Test; and Cobb measurement were used as outcome measures.

Results:
Positive changes were observed in the International Cooperative Ataxia Rating Scale; Quick Disability of the Arm, Shoulder, and Hand Questionnaire; Pediatric Quality of Life Inventory; Trunk Impairment Scale; Functional Independence Measure; and the 9-Hole Peg Test. The Cobb angle was increased by 2° in the thoracic region and reduced by 11° in the lumbar region.

Conclusions:
Physical therapy improved quality of life, functional independence, trunk control, and upper extremity performance.

What This Adds to Evidence:
This case report is the first to support the effectiveness of physical therapy for a child with CALFAN syndrome.
Infants With Congenital Muscular Torticollis Requiring Supplemental Physical Therapy Interventions
Authors: Greve Kelly R. , Goldsbury Courtney M. , Simmons Erin A. 
Published: May 2022

Purpose:
To describe supplemental intervention (SI) frequency in infants with congenital muscular torticollis (CMT) and compare groups of infants who received first-choice intervention only to infants who received SI.

Methods:
Data were retrospectively extracted from a registry. Baseline and treatment variables were collected and analyzed.

Results:
The cohort included 907 infants with 85 receiving SI. Order of SI frequency was kinesiological tape, manual techniques, tubular orthosis for torticollis (TOT) collar, and the Benik system. Statistically significant differences were found in baseline age, passive cervical range of motion (ROM), muscle function, and treatment time between groups. A positive association was found for CMT presentation, classification grade, plagiocephaly type, and external referrals between groups.

Conclusions:
Nine percent of infants received SI, most frequently kinesiological tape. Infants who received SI had larger baseline passive ROM and muscle function differences and more visits over a longer duration but had similar CMT resolution. Education is needed when using SI.
Structuring Equity Into Minnesota's COVID-19 Response: Lessons Learned and Future Investments
Authors: Chute Sara , Chomilo Nathan T. , Dionne Jackie , Huntley Chelsie , Linde Ann , Wanduragala Danushka 
Published: May 2022

Background:
The Minnesota Department of Health (MDH) integrated 3 intentional teams into their novel coronavirus 2019 (COVID-19) response to ensure equity was not lost in the speed of response.

Implementation:
These teams—the Cultural, Faith, and Disability Communities Branch, Tribal COVID-19 Healthcare Team, and Vaccine Equity Branch were able to reach communities through trusted partners, elevate the voices of communities most impacted, respect tribal sovereignty, establish equity leadership, and set equity goals and metrics.

Lessons Learned:
The top-down nature of incident command, combined with pre-COVID-19 systems and structures that impede equity, led to both barriers and opportunities for centering equity in response efforts. Inclusion of staff and community voice in decisions and guidance leads to better results; each community's unique needs have to be considered. Equity metrics and goals help direct resources to the most disadvantaged. State, local, and tribal public health infrastructure was built quickly and needs ongoing resources to be sustained.

Future Investments:
MDH is leveraging new funding to embed successful response structures into the organization. These structures are intended to build state, local, and tribal capacity and address systemic challenges at MDH.

Conclusion:
While equity can be incorporated into pandemic response and incident command structures, ongoing investment to support public health infrastructure is vital to sustaining equity.
Lessons Learned: The Varied Responses of Massachusetts' Local Health Departments During the COVID-19 Pandemic
Authors: Mauzy Steven , Putney Kimberly , Baroni Emily , Dey Andrew , Elangovan Kavya , Ji Grace , McHale Samantha , Prabha Gargi , Sarkisova Natalya , Granger Stephanie , Black Kristin , Lindenmayer Joann 
Published: May 2022

Context:
Massachusetts' decentralized public health model holds tightly to its founding principle of home rule and a board of health system established in 1799. Consequently, Massachusetts has more local health departments (n = 351) than any other state. During COVID-19, each health department, steeped in centuries of independence, launched its own response to the pandemic.

Objectives:
To analyze local public health resources and responses to COVID-19.

Design:
Semistructured interviews and a survey gathered quantitative and qualitative information about communities' responses and resources before and during the pandemic. Municipality demographics (American Community Survey) served as a proxy for community health literacy. We tracked the frequency and content of local board of health meetings using minutes and agendas; we rated the quality of COVID-19 communications on town Web sites.

Setting:
The first 6 months of the COVID-19 pandemic in Massachusetts: March-August 2020.

Participants:
Health directors and agents in 10 south-central Massachusetts municipalities, identified as the point of contact by the Academic Public Health Corps.

Main Outcome Measures:
We measured municipality resources using self-reported budgets, staffing levels, and demographic-based estimates of community health literacy. We identified COVID-19 responses through communities' self-reported efforts, information on town Web sites, and meeting minutes and agendas.

Results:
Municipalities excelled in communicating with residents, local businesses, and neighboring towns but lacked the staffing and funding for an efficient and coordinated response. On average, municipal budgets ranged from $5 to $16 per capita, and COVID-19 consumed 75% of health department staff time. All respondents noted extreme workload increases. While municipal Web sites received high scores for Accurate Information, other categories (Navigability; Timeliness; Information Present) were less than 50%.

Conclusions:
Increased support for regionalization and sustained public health funding would improve local health responses during complex emergencies in states with local public health administration.
Exploring Care Left Undone in Pediatric Nursing
Authors: Bagnasco Annamaria , Rossi Silvia , Dasso Nicoletta , Catania Gianluca , Zanini Milko , Aleo Giuseppe , Scelsi Silvia , Petralia Paolo , Watson Roger , Sasso Loredana 
Published: May 2022

Objectives
This study aimed to investigate the association between nursing care left undone in pediatrics and factors related to nursing staff characteristics and work environment.

Methods
The data of the present study were extracted from our RN4CAST@IT-Ped database, a cross-sectional observational study, which included 13 hospitals belonging to the Italian Association of Paediatric Hospitals. Through convenience sampling, nurses and pediatric nurses providing direct care in routine pediatric wards were enrolled in the study. Data aggregated by clinical care area were analyzed, through descriptive and inferential statistics methods using IBM SPSS 22.0 software.

Results
We collected data from 399 pediatric nurses working in surgical wards, 1208 in medical wards, and 631 in critical care units. Some of the investigated factors have shown an association with the risk of omitting essential nursing activities, like health care judged of poor quality, patient safety judged as poor, and nurses’ intention-to-leave the job. For every nursing activity under investigation, we found some significant statistical associations.

Conclusions
Our results are consistent with the international literature showing that nurses miss some activities more frequently. Understanding the associations underpinning care left undone could be a starting point for the implementation of patient-centered care and the improvement of the quality and safety of care in pediatric settings, as well as the work environment.
Understanding Hazards for Adverse Drug Events Among Older Adults After Hospital Discharge: Insights From Frontline Care Professionals
Authors: Xiao Yan , Smith Aaliyah , Abebe Ephrem , Hannum Susan M. , Wessell Andrea M. , Gurses Ayse P. 
Published: May 2022

Objectives
Care transitions pose a high risk of adverse drug events (ADEs). We aimed to identify hazards to medication safety for older adults during care transitions using a systems approach.

Methods
Hospital-based professionals from 4 hospitals were interviewed about ADE risks after hospital discharge among older adults. Concerns were extracted from the interview transcript, and for each concern, hazard for medication-related harms was coded and grouped by its sources according to a human factors and systems engineering model that views postdischarge ADEs as the outcome of professional and patient home work systems.

Results
Thirty-eight professionals participated (5 hospitalists, 24 nurses, 4 clinical pharmacists, 3 pharmacy technicians, and 2 social workers). Hazards were classified into 6 groups, ranked by frequencies of hazards coded: (1) medication tasks related at home, (2) patient and caregiver related, (3) hospital work system related, (4) home resource related, (5) hospital professional-patient collaborative work related, and (6) external environment related. Medications most frequently cited when describing concerns included anticoagulants, insulins, and diuretics. Top coded hazard types were complex dosing, patient and caregiver knowledge gaps in medication management, errors in discharge medications, unaffordable cost, inadequate understanding about changes in medications, and gaps in access to care or in sharing medication information.

Conclusions
From the perspective of hospital-based frontline health care professionals, hazards for medication-related harms during care transitions were multifactorial and represented those introduced by the hospital work system as well as defects unrecognized and unaddressed in the home work system.
Growth Differentiation Factor-15 Correlates with Mortality and Severity in Severe Burns
Authors: Onishi Shinya , Ebihara Takeshi , Togami Yuki , Matsubara Tsunehiro , Matsumoto Hisatake , Osuka Akinori , Ogura Hiroshi , Oda Jun 
Published: May 2022

ABSTRACT

Background:
Growth differentiation factor-15 (GDF-15) is expressed in almost all tissues of the body and is necessary for the body's defense response to stress such as inflammation. It has been reported to be associated with incidence and mortality in many diseases, including systemic inflammatory response syndromes. There are no reports on GDF-15 in burns. The purpose of this study was to investigate the trend of GDF-15 in blood in patients with severe burns and to determine its relationship with severity and mortality.

Methods:
This was a retrospective, observational, single-center study. The level of GDF-15 in the blood was measured and compared with clinical parameters, including prognosis. Time points for sample collection were the day of injury, 4 days after injury, and 1 week after injury.

Results:
Eighty-three patients were enrolled in the study. At all time points, GDF-15 levels in the nonsurvivor group were significantly higher than those in the survivor group. In the analysis using the ROC curve for 28-day survival, the AUC of the GDF-15 value on the day of injury was 0.798, which was higher than those of % total body surface area, burn index, and Sequential Organ Failure Assessment (SOFA) score. GDF-15 levels correlated positively with SOFA score, and the relationship became stronger along with the time course of severe burn.

Conclusions:
In the acute phase of severe burn, GDF-15 levels were associated with mortality and SOFA scores.
The Las Vegas military-civilian partnership: An origin story and call to action
Authors: Kilburn Jeremy P. , Streit Stephanie , Degoes John J. , Andersen Allison , Gardner Michael , Fraser Douglas R. , Fildes John 
Published: May 2022

ABSTRACT
Military-civilian partnerships (MCPs) in urban American trauma centers have existed for more than 60 years to assist in the development and maintenance of wartime skills of military medical professionals. In the last 5 years, MCPs have gained congressional support, and their number and variety have grown substantially. The historical impact of these flagship trauma MCPs is well documented, with bidirectional benefit in the advancement of trauma care during the wars in Iraq and Afghanistan both deployed and stateside, and the future aim of MCPs lies primarily in mitigating the “peacetime effect.” The majority of data regarding MCPs; however, focus on trauma care and are biased toward surgeons specifically. The Las Vegas (LV) MCP began in 2002 with the similar goal of sustaining Air Force (AF) expeditionary medical skills by embedding AF medics from nearby Nellis Air Force Base (AFB) into University Medical Center of Southern Nevada (UMC), the only Level 1 Trauma Center in Nevada. Over nearly 20 years, the LV-MCP has evolved into an innovative market-based collaboration composed of numerous relationships and programs that are designed to develop and sustain critical skills for military medical personnel in all aspects of expeditionary medicine. This includes AF medical personnel providing care to federal beneficiaries as well as civilian patients in a variety of medical settings. The partnership's central coordinating authority, the Office of Military Medicine-Las Vegas (OMM-LV), brings together military and civilian organizations with distinct and intersecting missions to support the greater LV population and the DoD mission of readiness. The LV-MCP is presented here as a model for the future of MCPs within the integrated local and national trauma and medical systems.
Synaptic resilience is associated with maintained cognition during
ageing
Authors: King Declan , Holt Kris , Toombs Jamie , He Xin , Dando Owen , Okely J. A. , Rose Jamie , Gunn Ciaran , Correia Adele , Montero Carmen , Tulloch Jane , Lamont Douglas , Taylor Adele M , Harris Sarah E , Redmond Paul , Cox Simon R , Henstridge Christopher M , Deary Ian J , Smith Colin , Spires-Jones Tara L 
Published: May 2022

ABSTRACT

INTRODUCTION
It remains unclear why age increases risk of Alzheimer’s disease and why
some people experience age-related cognitive decline in the absence of
dementia. Here we test the hypothesis that resilience to molecular changes
in synapses contribute to healthy cognitive ageing.

METHODS
We examined post-mortem brain from people in mid-life (n=15), healthy
ageing with either maintained cognition (n=8) or lifetime cognitive decline
(n=7), and Alzheimer’s disease (n=13). Synapses were examined with high
resolution imaging, proteomics, and RNA sequencing. Stem cell-derived
neurons were challenged with Alzheimer’s brain homogenate.

RESULTS
Synaptic pathology increased, and expression of genes involved in
synaptic signalling decreased between mid-life, healthy ageing and
Alzheimer’s. In contrast, brain tissue and neurons from people with
maintained cognition during ageing exhibited decreases in synaptic
signalling genes compared to people with cognitive decline.

DISCUSSION
Efficient synaptic networks without pathological protein accumulation
may contribute to maintained cognition during ageing.
Correlated retrograde and developmental regulons implicate multiple retrograde signals as coordinators of chloroplast development in maize
Authors: Kendrick Rennie , Chotewutmontri Prakitchai , Belcher Susan , Barkan Alice 
Published: May 2022

AbstractSignals emanating from chloroplasts influence nuclear gene expression, but roles of retrograde signals during chloroplast development are unclear. To address this gap, we analyzed transcriptomes of four non-photosynthetic maize mutants and interpreted them in the context of transcriptome dynamics during normal leaf development. We analyzed two albino mutants lacking plastid ribosomes and two chlorotic mutants with thylakoid targeting or plastid transcription defects. The ∼2700 differentially expressed genes fall into six major categories based on the polarity and mutant-specificity of the change. These distinct retrograde responses correlate with distinct developmental dynamics, with down-regulated genes expressed later in normal development and up-regulated genes acting early. Photosynthesis genes are down-regulated specifically in the albino mutants, whereas up-regulated genes are enriched for functions in chloroplast biogenesis and cytosolic translation. TOR signaling is elevated in plastid ribosome-deficient mutants and declines in concert with plastid ribosome buildup during leaf development. Our results implicate three plastid signals as integral players during photosynthetic differentiation. One signal requires plastid ribosomes and activates photosynthesis genes. A second signal reflects attainment of chloroplast maturity and represses chloroplast biogenesis genes. A third signal responds to nutrient consumption by developing chloroplasts and represses TOR, which down-regulates cell proliferation genes early in leaf development.One sentence summaryTranscriptomes of non-photosynthetic maize mutants when interpreted in the context of normal developmental dynamics implicate three plastid signals as coordinators of photosynthetic differentiation.The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (https://academic.oup.com/plcell/pages/General-Instructions) is Alice Barkan (abarkan@uoregon.edu)