bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying evolving priorities in national river governance from Parliamentary Questions
Authors: Azhoni Adani , Holman Ian , Grabowski Robert C. 
Published: September 2022

Abstract
Rivers and their surrounding land provide resources and services that result in trade-offs requiring legislative and institutional interventions, for which the perspectives of law-policymakers and their societal values and political expediencies play a major role in decision-making. This study critically evaluates the evolving land–river governance in large democratically elected governments with complex developmental priorities and how law-policymakers’ recognition of emerging issues of river management influences common pool environmental resources governance. We selected an emerging economy – India – and analysed Parliamentary Questions (PQs) between 1999 and 2020 using a mixed method approach. Conflicting priorities over economic development, pollution management, socio-cultural values and inter-state–centre issues shape the evolving priorities of land–river governance. A declining focus on large-scale dams coupled with increasing attention on inter-basin water transfers, river conservation and pollution abatement, demonstrates an evolution away from the earlier narrow view of rivers for irrigation and hydropower. Our analysis demonstrates how the priorities of law-policymakers and political expedience play a critical role in river governance and thereby provide important insights into common pool environmental resources governance for sustainable development while also identifying important knowledge gaps and suggesting scopes for interdisciplinary studies.
WDFY3-AS2: A Potential Prognostic Factor and Therapeutic Target
Related to Cancer
Authors: Mou Jie , Chen Jinlan , Wu Yinxin , He Yuequan , Zhou Gang , Yuan Chengfu 
Published: September 2022

Background:
Abundant studies have shown that non-coding RNA is connected
with tumor cell growth, migration and invasion. As a newly discovered non-coding
RNA, WDFY3-AS2 has gradually emerged in the molecular mechanism of various tumors
and has a potential prospect as a biological indicator of tumor prognosis. This review
describes the pathophysiological mechanism and prognostic value of WDFY3-AS2
in different cancers.

Objective:
This review reveals the changes and roles of WDFY3-AS2 in many tumors
and cancers. The change of WDFY3-AS2 can be used as a cancer biomarker and plays
an important role in improving tumor growth, migration and invasion. WDFY3-AS2 is
unique because it can be considered a prognostic marker for many tumors and is of great
significance for clinical diagnosis and treatment. WDFY3-AS2 shows the potential prognostic
value and the prospect of therapeutic targets in various tumors.

Methods:
PubMed reviewed the related literature to analyze and summarize the regulatory
molecular mechanism of WDFY3-AS2 in various tumors and its value as a prognostic
indicator.

Results:
The abnormal expression of LncRNA WDFY3-AS2 in many cancers was connected
with the poor prognosis of cancer patients, including diffuse glioma, hepatocellular
carcinoma, ovarian cancer, esophageal cancer, triple-negative breast cancer, Clear
Cell Renal Carcinoma, Esophageal squamous cell carcinoma, Lung adenocarcinoma,
which participated in the recovery of orthodontic teeth. WDFY3-AS2 has revealed the
cellular process of cancer cell growth, migration, and invasion.

Conclusion:
The molecular mechanism of LncRNA WDFY3-AS2 regulating tumor specifically
proves that WDFY3-AS2 has a good prospect in the biological index of prognosis
or clinical treatment target of cancer patients.
A Review on Traditional Anti-ulcer Medicinal Plants
Authors: Singh Ambrish K. , Shahzad Naiyer , Arun Priyamvada , Shukla Jyoti , Kumar Ajay , Nandi Manmath K. , Abduljaleel Zainularifeen , Al-Ghamdi Saeed S. , Alzahrani Abdullah R. 
Published: September 2022

Abstract:
Traditional remedies have been used for generations to treat and maintain people's health and indigenous medicinal plants are an important part of this system, which, unlike western medicine, provides cures for practically all illnesses with no side effects. Such an ulcer is a chronic ailment that affects most of the world's population and has no absolute cure. An ulcer is the erosion of mucous lining in the gastrointestinal tract due to over secretion of HCl in the stomach, leading to inflammation and soreness. Consumption of highly spicy meals, an obese lifestyle, an unplanned diet, the use of excessive non-steroidal anti-inflammatory medicines, smoking, stress, an irregular sleep cycle, and regular alcohol consumption are all possible causes of ulcers. Ayurvedic and traditional medicine practitioners employ a variety of indigenous medicinal plants to cure ulcers. This review covers a wide variety of medicinal plants that may work as anti-ulcer and deserves more investigation.
Triacylglycerols are a Rich Source of Polyunsaturated Fatty Acids in Red
King Crab Juveniles (Paralithodes camtschaticus)
Authors: Sikorskaya Tatyana V. 
Published: September 2022

Abstract:
In the Sea of Japan and the Okhotsk Sea, the red king crab Paralithodes camtschaticus
is the major commercial species of the crab. The crab is a rich source of polyunsaturated fatty acids
(PUFAs). The composition of triacylglycerol (TG) molecular species in freshly collected juveniles
of P. camtschaticus has been determined for the first time. By supercritical fluid chromatography
with mass-spectrometry, 45 molecular species of TG were identified. Most of the molecular
species contained docosahexaenoic acid (DHA; 22:6n-3), eicosapentaenoic acid (EPA;
20:5n-3), arachidonic acid (AA, 20:4n-6), and monounsaturated fatty acid 18:1. Thus, DHA,
EPA, and AA received from the diet are used to build phospholipids (PL) and also stored in TG
in P. camtschaticus juveniles. Therefore, the crab is a rich source of PUFAs, which are concentrated
both in structural PL and in reserve TG.
Orally Administered Curcumin Inhibits Breast Cancer In vivo and
Reduces Cell Proliferation In vitro in an Iron Dependent Manner
Authors: Inzunza-Soto Marce , Leal-León Emir , Vergara-Jiménez Marcela , López-Moreno Samuel , Cedano-Prieto Dora Maria , Franco Moises , Jiménez-Ferrer Jesús Enrique , Alegría Herrera Elian Yuritzi , Alvarez Jonathan Cortés , Alemán-Hidalgo David , Teran-Cabanillas Eli 
Published: September 2022

BACKGROUNG:
Increased intracellular iron metabolism is a hallmark of breast cancer. Curcumin is an iron chelator with suggested anti-proliferative effects in breast cancer cell lines. However, preclinical studies in murine models are required to validate these important benefits

AIMS:
Therefore, this study was aimed to determine if the iron-chelating properties of curcumin are responsible for its anti-proliferative effect in breast cancer cells and to investigate the translation of this effect to in vivo models

METHODS:
For in vitro experiments, human MCF-7 and mouse 4T1 breast cancer cells were tested. Cell proliferation was assessed in presence and absence of different concentrations of FAC (ferric ammonium citrate) and curcumin. For in vivo studies, 4T1 cells were implanted into BALB/c mice. After tumor development, animals were divided into four groups (n=5); control, curcumin, optimized curcumin (OC) and chemotherapy group. Tumor volumes were calculated prior and posterior oral gavage treatments.

RESULT:
Curcumin inhibited cell proliferation in both MCF-7 and 4T1 cell lines in a seemingly iron-dependent manner. FAC addition inhibited the anti-proliferative effect exhibited by curcumin. Moreover, curcumin group showed a significantly decreased in tumor growth; interestingly, treatment with OC supplement induced the opposite effect.

CONCLUSION:
These results suggest that curcumin may have an important positive impact in breast cancer, due to its iron dependent anti-proliferative properties.
Lower Gastrointestinal Bleeding in the Emergency Department: High-
Volume vs. Low-Volume Peg Bowel Preparation for Colonoscopy: A
Randomized Trial
Authors: Saviano Angela , Petruzziello Carmine , Riccioni Maria Elena , Di Pumpo Marcello , Petrucci Martina , Brigida Mattia , Zanza Christian , Candelli Marcello , Franceschi Francesco , Ojetti Veronica 
Published: September 2022

Background:
Lower Gastrointestinal Bleeding (LGIB) is a common cause of
admission to the Emergency Department (ED). Early colonoscopy is the exam of choice for
evaluating LGIB, and an adequate colon cleansing is essential. High-volume solution 4L-PEG is
largely used, but it has some limitations. Low-volume solution 2L-PEG may improve patient’s
tolerability and compliance, reducing the time of administration and speeding up the exam.

Patients And Methods:
We conducted a randomized 1:1, prospective observational monocentric
study in 228 patients (144M/84F) with LGIB. 121 (69M/52F) received the High-Volume, while
107 (75M/32F) received Low-Volume. They completed a “satisfaction questionnaire” (taste and
smell, mood, time of taking, general experience). We collected the results of the Boston Bowel
Preparation Scale (BBPS) and the final diagnosis.
The study was retrospectively registered on clinicaltrial.gov with protocol number NCT0536
2227.

Results:
A mean value of BBPS 6,3 was achieved by both groups (p=0.57). Regarding smell,
taste, mood and time of taking (1 to 5), we do not find any statistically differences. The overall
satisfaction between the two preparations was 2.90 for low-volume compared to 3.17 for Highvolume
(p=0.06). No side effects were reported. The proportion of patients without an evident
source of bleeding was higher in High volume preparations compared to Low-volume (39% vs.
30%, respectively).

Conclusion:
Low volume bowel preparation showed the same efficacy and tolerability with
better satisfaction compared with high volume. Low-volume could represent an effective and
more desirable preparation for patients in the ED.

Clinical Trial Registration Number:
NCT05362227.
Perspective on Cav-1 for its Potential as Newer Therapeutics for
Parkinson’s Disease
Authors: Singh Gurpreet , Pushpa Tryphena K. , Gupta Sunil Kumar , Srivastava Saurabh , Khatri Dharmendra Kumar , Singh Shashi Bala 
Published: September 2022

Abstract:
Parkinson’s disease (PD) is the second most common neurodegenerative disease affecting
around 10 million people worldwide. Dopamine agonists that mimic the action of natural dopamine in
the brain are the prominent drugs used in the management of PD symptoms. However, the therapy is
limited to symptomatic relief with serious side effects. Phytocompounds have become the preferable
targets of research in the quest for new pharmaceutical compounds. In addition, current research is directed
towards determining a newer specific target for the better treatment and management of PD.
Cav-1, a membrane protein present on the caveolae of the plasma membrane, acts as a transporter for
lipid molecules in the cells. Cav-1 has been implicated in the pathogenesis of neurodegenerative diseases,
like Alzheimer’s disease (AD), PD, etc. In this review, we have extensively discussed the role
of Cav-1 protein in the pathogenesis of PD. In addition, molecular docking of some selective phytochemical
compounds against Cav-1 protein (Q03135) was performed to understand their role. The best
phytochemical compounds were screened based on their molecular interaction and binding affinity
with the Cav-1 protein model.
Preliminary User Evaluation of a New Dental Technology Virtual Simulation System: Development and Validation Study
Authors: Pang Mengwei , Zhao Xiaohan , Lu Daiyu , Dong Yihan , Jiang Lin , Li Jie , Ji Ping 
Published: September 2022

Background
With the advancements in the dental health care industry, the demand for dental technicians has increased. Dental technicians should be thoroughly assessed and trained in practical skills and pass professional certification examinations to ensure that they are competent to work closely with dentists. Unfortunately, such training courses and tests are in short supply worldwide. The use of virtual simulation technology can help solve these problems.

Objective
This study presents a new strategic framework design for a certified dental technician practical examination called as the certified Objective Manipulative Skill Examination of Dental Technicians (OMEDT), which is based on the Objective Structured Clinical Examination (OSCE). We present the development and validation of the OMEDT system, a new virtual simulated training system, to meet the demands of the OMEDT framework. The combination of OMEDT and the OMEDT system can solve the complex problems encountered in the certified dental technician practical examination with excellent efficiency, high quality, and low cost.

Methods
The OMEDT framework design was constructed according to the OSCE guide and the Chinese vocational skill standards for dental technicians. To develop the OMEDT system, we organized a new framework based on the virtual learning network platform, the haptic feedback system, and the real-time dental training and evaluation system. The effectiveness evaluation of the OMEDT system was divided into 2 phases: in the first phase, 36 students were recruited to use the test module to finish the task and their performance data were collected and analyzed; and in the second phase, a questionnaire was administered to 30 students who used the system for their studies and graduation exams.

Results
The OMEDT and the corresponding skill training virtual simulation OMEDT system were developed, and preliminary user evaluation was performed to assess their effectiveness and usefulness. The OMEDT system was found to improve students’ practical skills by training with the evaluation results. In addition, several key research topics were explored, including the effects of positive feedback of the knowledge of results on the improvement of the students’ skill level and the common sense transformation of educators in the virtual simulation technology environment.

Conclusions
The development of OMEDT and the OMEDT system has been completed and their effectiveness has been verified.
A Bioinformatics Tool for Predicting Future COVID-19 Waves Based on a Retrospective Analysis of the Second Wave in India: Model Development Study
Authors: Kumar Ashutosh , Asghar Adil , Dwivedi Prakhar , Kumar Gopichand , Narayan Ravi K , Jha Rakesh K , Parashar Rakesh , Sahni Chetan , Pandey Sada N 
Published: September 2022

Background
Since the start of the COVID-19 pandemic, health policymakers globally have been attempting to predict an impending wave of COVID-19. India experienced a devastating second wave of COVID-19 in the late first week of May 2021. We retrospectively analyzed the viral genomic sequences and epidemiological data reflecting the emergence and spread of the second wave of COVID-19 in India to construct a prediction model.

Objective
We aimed to develop a bioinformatics tool that can predict an impending COVID-19 wave.

Methods
We analyzed the time series distribution of genomic sequence data for SARS-CoV-2 and correlated it with epidemiological data for new cases and deaths for the corresponding period of the second wave. In addition, we analyzed the phylodynamics of circulating SARS-CoV-2 variants in the Indian population during the study period.

Results
Our prediction analysis showed that the first signs of the arrival of the second wave could be seen by the end of January 2021, about 2 months before its peak in May 2021. By the end of March 2021, it was distinct. B.1.617 lineage variants powered the wave, most notably B.1.617.2 (Delta variant).

Conclusions
Based on the observations of this study, we propose that genomic surveillance of SARS-CoV-2 variants, complemented with epidemiological data, can be a promising tool to predict impending COVID-19 waves.
Physical and Chemical Properties Improvement of Soils from Progo River Estuarine after Rehabilitation using Sonneratia sp
Authors: Faridah Eny , Prehaten Daryono , Koranto Cahyono Agus Dwi , Atmanto Winastuti Dwi , Supriyo Haryono , Nurjanto Handojo Hadi 
Published: September 2022

Mangrove planting in Progo River Esturaine in Kulon Progo was hindered by its marginal conditions, where the land was dominated by very dynamic sandy substrat. This condition has caused the growth of various planted mangrove seedlings by Forestry UGM team (2015-2016) was very low. Nevertheless, it was found that Sonneratia can grow well in the location. It was expected that Sonneratia can improve site condition so it became suitable for the growth of other mangrove species. This research aimed to assess soil properties of Progo River estuarine after rehabilitation using Sonneratia. Characterisation of soil physical (texture) and chemical (salinity, pH, and soil organic matter) properties were conducted in the Laboratory of Tree Physiology and Forest Soil, Faculty of Forestry UGM. Soil samples were collected from Sonneratia plant area in various growing conditions. The results showed that growth of Sonneratia affected soil physical properties particularly increasing the proportion of clay and silt, but not soil texture class. In general, more proportion of clay and sand were detected in the bigger Sonneratia plants and in the outer section of root system. The growth of Sonneratia also affected soil chemical properties particularly soil organic matter but not soil pH and salinity.
Pemahaman Menjauhi Zina menurut Pandangan Mufasir
Authors: Ramli Nafisah Binti 
Published: September 2022

Social phenomena that occur in today's society, especially young people cannot distinguish between actions that can bring them closer to adultery. To avoid mistakes in understanding religion, it is necessary to study the understanding of the verses of the Qur'an from the opinions of the commentators, both classical and contemporary interpreters. This study is bibliographic in nature, and the data were obtained through the tahlili interpretation method. The main focus of this paper is to see the understanding of the commentators about the verse lâ taqrabu fornication. The results showed that the mufassir understood the meaning of lâ taqrabu adultery to include a prohibition on all actions that encourage adultery, both externally such as dating, ikhtilat between men and women, handshakes between men and women, showing jewelry, wearing perfumes in public places. public, technological advances, as well as internal ones, such as daydreaming, so as to arouse feelings and hearts. Fenomena sosial yang terjadi dalam masyarakat sekarang, terutama kaum muda mudi tidak dapat membedakan perbuatan yang dapat mendekatkan mereka pada zina. Untuk menghindari kekeliruan dalam memahami agama, perlu kajian tentang pemhaman ayat-ayat Al-Qur’an dari pendapat para mufasir, baik penafsir klasik maupun kontemporer. Kajian ini bersifat kepustakaan, dan data didapatkan melalui metode tafsir tahlili. Fokus utama tulisan ini adalah melihat pemahaman para mufasir tentang ayat lâ taqrabu zina. Hasil penelitian menunjukan bahwa mufassir memahami makna lâ taqrabu zina adalah mencakup larangan terhadap seluruh perbuatan yang mendorong kepada perbuatan zina, baik yang bersifat eksternal seperti berpacaran, ikhtilat antara laki dan perempuan, jabat tangan antara laki dan perempuan, memperlihatkan perhiasan, memakai wangi-wangian di depan umum, kemajuan teknologi, maupun yang sifatnya internal, seperti menghayal, sehingga menggugah perasaan dan hati.
Kualitas Hadis dalam Kitab Pelajaran Akhlak Karya Adnan Yahya Lubis
Authors: Mawarni Sari 
Published: September 2022

In the daily practice of Islamic teachings, it is found that some hadiths of unknown quality circulate among the general public and are used as references to educational institutions. The Book of Morals by Adnan Yahya Lubis is one of the works that contains traditions without mentioning the chain of transmission, but has been used as a reference in Islamic boarding schools and other educational institutions. Therefore, a study of the quality of the traditions in the book needs to be done academically, so that it can be seen whether the traditions contained in the book are of maqbul or mardud quality. This research is a literature study, data collection is done through takhrij hadith and analyzed through the jarh wa ta'dil science approach. The results showed that the majority of the hadith studied were narrated by Imam Ahmad, Ali, al-Tirmidhi, Ibn Majah, al-Darimi, Imam Bukhari, Imam Muslim, al-Nasa'i, Imam Malik, Abu Dawud. Of the five samples of hadith examined for the quality of the sanad, one quality hadith is authentic from Imam Ahmad's history, one is hasan quality from Tirmidhi's history, two hadiths are of da'if quality from the path of Imam Ahmad and from the path of Ibn Majah, and one is qualified mawdu' from the history of Ali. It can be concluded that the hadiths in the Moral Lesson book are of maqbul quality and some are mardud. Dalam pengamalan ajaran Islam sehari-hari, ditemukan beberapa hadis yang tidak diketahui kualitasnya beredar di kalangan masyarakat umum dan dijadikan rujukan pada lemabag-lembaga pendidikan. Kitab Pelajaran Akhlak karangan Adnan Yahya Lubis adalah salah satu karya yang memuat hadis-hadis tanpa menyebut sanad periwayatannya, akan tetapi telah dijadikan rujukan di pesantren dan lembaga pendidikan lainnya. Oleh karena itu, kajian terhadap kualitas hadis-hadis dalam kitab tersebut perlu dilakukan secara akademis, sehingga dapat dilihat apakah hadis-hadis yang dimuat dalam kitab tersebut berkualitas maqbul atau mardud. Penelitian ini bersifat kajian kepustakaan, pengumpulan data dilakukan melalui takhrij hadis dan dianalisis memalui pendekatan ilmu jarh wa ta’dil. Hasil penelitian menunjukan bahwa mayoritas hadis yang diteliti, diriwayatkan oleh Imam Ahmad, Ali, al-Tirmidhi, Ibnu Majah, al-Darimi, Imam Bukhari, Imam Muslim, al-Nasa’i, Imam Malik, Abu Dawud. Dari lima buah sampel hadis yang diteliti kualitas sanad, satu hadis berkualitas sahih riwayat Imam Ahmad, satu berkualitas hasan riwayat Tirmidhi, dua hadis berkualitas da’if dari jalur Imam Ahmad dan dari jalur Ibnu Majah, dan satu berkualitas mawdu’ dari riwayat al-Ali. Dapat disimpulkan bahwa hadis-hadis dalam kitab Pelajaran Akhlak ada yang berkualitas maqbul dan ada yang mardud.
Making Sense of Ego Depletion: The Replication Crisis, A Path Forward, and Lessons for Accounting Researchers
Authors: Hurley Patrick J. 
Published: September 2022

SUMMARY
Ego depletion, an influential social psychology theory that has been applied in auditing research, is currently in crisis following unsuccessful attempts to replicate the phenomenon. I summarize the questions surrounding ego depletion as a phenomenon and the strength model of self-control as its theoretical explanation. Existing evidence suggests that depletion is a real phenomenon but that its effect is likely overstated in prior literature. However, it seems that the strength model is not the best theoretical explanation for depletion. To provide a path forward to continue investigating this phenomenon, I describe four alternative theories from prior literature. Highlighting motivation as a common thread in these theories, I then propose a new theory that views ego depletion as transient cognitive fatigue. Finally, I discuss opportunities for future research in auditing, best practices for the design of these studies, and meta-lessons that accounting researchers can take from crises in psychology research.