bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of oestradiol treatment on hot flushes in men undergoing androgen deprivation therapy for prostate cancer: a randomised placebo-controlled trial
Authors: Russell Nicholas , Hoermann Rudolf , Cheung Ada S , Zajac Jeffrey D , Grossmann Mathis 
Published: September 2022

Abstract

Objective
Most men undergoing androgen deprivation therapy (ADT) for prostate cancer experience hot flushes. Current treatments have low or limited evidence of efficacy. It is likely that oestradiol depletion is the mediator of these hot flushes, and transdermal oestradiol might be an effective treatment.

Design
This is a 6-month randomised, placebo-controlled trial with the hypothesis that oestradiol would reduce hot flush frequency and intensity and improve quality of life (QoL).

Methods
Seventy-eight participants receiving ADT were randomised to 0.9 mg of 0.1% oestradiol gel per day or matched placebo. Hot flush frequency and severity were assessed by 7-day diary at baseline, month 1, month 3, and month 6. QoL was assessed by validated questionnaire.

Results
Oestradiol reduced daily hot flush frequency, with a mean adjusted difference (MAD) of −1.6 hot flushes per day (95% CI: −2.7 to −0.5; P = 0.04). The effect on weekly hot flush score was non-significant, with a MAD –19.6 (95% CI: −35.5 to −3.8; P = 0.11). On per protocol analysis, E2 significantly reduced daily hot flush frequency, with a MAD of −2.2 hot flushes per day (95% CI: −3.2 to −1.1; P = 0.001), and weekly hot flush score, with a MAD of −27.0 (−44.7 to −9.3; P = 0.02). Oestradiol had no significant effect on QoL.

Conclusion
We confirmed our hypothesis of a clinical effect of assignment to oestradiol to reduce hot flush frequency in men with castrate testosterone due to ADT. Transdermal oestradiol could be considered for men with burdensome hot flushes in whom other treatments have failed as long as the risk of breast effects and fat gain are considered.
Unusual presentation of lung carcinoma with pituitary metastasis: a challenging diagnosis and sodium management dilemmas
Authors: Wong Poh Shean , Rajoo Subashini , Achmad Sankala Hairuddin , Long Bidin Mohamed Badrulnizam 
Published: September 2022

Summary
Pituitary metastasis (PM) is a rare complication of an advanced malignancy. Albeit rare, PM can be more detected and achieve a longer survival rate through frequent neuroimaging and newer oncology therapies. Lung cancer is the most frequent primary site, followed by breast and kidney cancers. Patients with lung cancer generally present with respiratory symptoms and are commonly diagnosed at an advanced stage already. Nevertheless, physicians should be mindful of other systemic manifestations as well as signs and symptoms related to metastatic spread and paraneoplastic syndromes. Herein, we report the case of a 53-year-old woman who presented with PM as the first sign of an undiagnosed lung cancer. Initially, her condition was a challenging diagnosis and was even complicated with diabetes insipidus (DI), which can present as severe hyponatremia when coexisting with adrenal insufficiency. This case also highlights that treating DI with antidiuretic hormone (ADH) replacement was complicated by extreme difficulties in attaining satisfactory sodium and water balance during the clinical course, with the possibility of coexistent DI and syndrome of inappropriate ADH secretion because of the underlying lung cancer.

Learning points

When patients present with pituitary mass and diabetes insipidus (DI), pituitary metastasis should be considered as an initial differential diagnosis. DI caused by pituitary adenoma is rare and is typically a late finding.

DI can present as severe hyponatremia when coexisting with adrenal insufficiency.

Cortisol can directly inhibit endogenous antidiuretic hormone (ADH) secretion. Patients with adrenocorticotropic hormone deficiency will have increased tonic ADH activity and subsequently reduced capacity for free-water excretion. However, when on steroid therapy, patients should be monitored for possible DI because steroids can restore free-water excretion.

A substantial change in serum sodium after desmopressin treatment should eliminate the possibility of desmopressin overdose or coexistence of DI and syndrome of inappropriate ADH secretion in patients with lung cancer. Therefore, frequent monitoring of serum sodium concentrations is crucial.
Semen characteristics of individuals before and after Covishield™ vaccination
Authors: Meitei Huidrom Yaiphaba , Uppangala Shubhashree , Lakshmi R Vani , Kalthur Guruprasad , Adiga Satish Kumar 
Published: September 2022

Concern about fertility impairment after vaccination is one of the reasons for vaccine hesitancy in the population. This retrospective observational study aims to understand the impact of Covishield™ (ChAdOx1 nCoV-19 corona virus vaccine, recombinant) COVID-19 vaccination on ejaculate quality in 53 patients undergoing semen analysis between 2018 and 2021. A baseline semen profile was recorded from the subjects during their visit before the vaccination for fertility work-up. Follow-up ejaculates were provided approximately 82 (Q1: 37, Q3: 124) days after the second dose of vaccination. Semen characteristics such as volume, sperm concentration, sperm motility, and morphological abnormalities were recorded. Of the 53 subjects, 33 (62%) had semen characteristics above the World Health Organization (WHO) reference. In general, no significant variations in the semen parameters were observed except for a moderate decline in sperm morphology (P <  0.05). The baseline semen characteristics in 20 (38%) subjects were below the WHO reference range; however, no significant decline in the ejaculate quality was observed in their follow-up samples. Further, none of the ejaculates in both study groups were azoospermic during the follow-up evaluation. Our results affirm that CovishieldTM vaccine is not detrimental to male fertility.

Lay summary
Concern about fertility impairment after vaccination is one of the reasons for vaccine hesitancy in the population. This study is aimed at understanding the impact of non-mRNA COVID-19 vaccination on ejaculate quality in 53 patients undergoing semen analysis who received Covishield™ (ChAdOx1 nCoV-19 corona virus vaccine, recombinant) vaccine. No significant variation in the semen characteristics was observed between the baseline and follow-up samples in the vaccinated subjects. Results from this study affirm that Covishield™ vaccination is not detrimental to male fertility.
Análisis de la ganancia de aprendizaje en la enseñanza de las ecuaciones lineales implementando un entorno personal de aprendizaje
Authors: Montero Cortés Lizeth Johanna 
Published: September 2022

Este trabajo da a conocer los efectos generados a partir de la implementación de un Entorno Personal de Aprendizaje (PLE, por sus siglas en inglés) en estudiantes de grado noveno de la Institución Educativa El Bosque.
El análisis se basa en el coeficiente de concentración de Hake con la finalidad de determinar las tendencias en las respuestas y la ganancia de aprendizaje de conceptos en el proceso de enseñanza de las ecuaciones lineales. Adicionalmente, muestra el cambio de recursos por medio del uso de varias herramientas web, las cuales son diferentes y particulares para cada uno de los estudiantes: Este es el principio del PLE, generar autonomía.
Esta propuesta surge como respuesta a los bajos resultados presentados en los últimos años en las pruebas saber y la falta de recursos tecnológicos en la Institución. Los análisis se realizan desde dos enfoques: ganancia de aprendizaje y motivación.
ADLİ KONTROL TEDBİRLERİ ÇERÇEVESİNDE GEÇİRİLEN SÜRELERİN MAHSUBU VE TAZMİNİ
Authors: YAŞAR Ercan 
Published: September 2022

Ceza muhakemesi hukuku uygulamasına Fransız hukukundan esinlenerek alındığı bilinen adli kontrol tedbirleri öncelikli olarak tutuklama koruma tedbirine seçenek olması düşüncesiyle getirilmiştir. Çeşitli şekillerde ortaya çıkan bu adli kontrol tedbirlerinin bazılarının kişi hürriyeti üzerinde ciddi kısıtlamalara sebebiyet verdiğini bilinmektedir. Temel hak ve hürriyetlere ciddi müdahale bu tedbirlerin tutuklama tedbirine seçenek oluşturmalarından da kaynaklanmaktadır. Kişi hürriyetinin kısıtlanması konutu terk etmeme yükümlülüğünde olduğu gibi bazı durumlarda fiili olarak tutukevinde bulunmaya neredeyse eşdeğer neticeler doğurmaktadır. Kimi adli kontrol tedbirlerinde ise bu temel hak ve hürriyetlere müdahale görece daha hafif bir hal teşkil etmektedir. Kanun koyucu son dönemlerde mahsup ve tazminata ilişkin artan tartışmaları gidermek için birtakım değişikliklere gitmiş ancak bu mahsup halini sınırlı tedbir türüne hasretmiş ve fakat tazminata ilişkin ise bir düzenlemeye yer vermemiştir.
Çalışma ile mevcut kanun düzenlemeler çerçevesinde mahsup ve veya tazminata ilişkin diğer adli kontrol tedbirlerini kapsayıcı bir uygulamanın mümkün olup olmadığı öğreti ve uygulamada verilen kararlar çerçevesinde ele alınacaktır.
Mabel Paola López Jerez. Morir de amor. Violencia conyugal en la Nueva Granada. Siglos XVI a XIX.
Authors: Bohórquez Forero Andrés Felipe 
Published: September 2022

En 1806, en el proceso iniciado por Josefa Callejas contra su esposo José Ignacio Ramil —quien era oficial de herrero y tenía cincuenta años—, con ocasión de los malos tratos de palabras, golpes y amenazas de muerte con un cuchillo que había sufrido constantemente por parte de él durante sus años de matrimonio, el abogado defensor alegó que: “El contrato matrimonial es contrato oneroso que nos impone la obligación de sufrir sus defectos con paciencia. Si vosotras sabéis callar, ahorrareis muchas pesadumbres y sinsabores” (p. 20). De esta manera, Mabel Paola López Jerez nos introduce en un tema doloroso y poco estudiado en la historiografía colombiana, vital para conocer nuestro pasado histórico: la violencia conyugal.
„Videmus nunc per speculum“ Selbstrepräsentation und Belehrung auf dem Kupferstich in Aenigma theologicum von Álvaro de Cienfuegos
Authors: Majorossy Imre Gábor 
Published: September 2022

AbstractThe paper deals with the copperplate engraving that stands at the beginning of the main theological treatise of Álvaro de Cienfuegos, bishop of Pécs (Hungary) between 1737 and 1739. The sophisticated work includes also an artistic engraving which is clearly part of the written treatise. The study aims to point out how comprehensively the engraving presents the author's basic intellectual attitude and essential details of the theoretical work. It is a real challenge for the audience of all times: Only in the case of a successful decoding it is possible to feel not only worthy, but also suitable and prepared to read, study and understand the two-volume treatise.
Biblical criticism and congregational singing two Unitarian translations of the Book of Psalms in 16–17th-century Transylvania
Authors: Etlinger Mihály , Szatmári Áron 
Published: September 2022

AbstractWithin half a century, there were two Unitarian authors who created rhymed Hungarian translations of the Book of Psalms – Miklós Fazakas Bogáti at the end of the 16th century and János Thordai in 1627. There are still unanswered questions regarding these translations: why did Bogáti's translation not spread among Unitarian congregations? Was Thordai acquainted with Bogáti's translation?This paper explores the circle of possible answers to these questions from various perspectives. It also examines Bogáti's biography and the subsequent legacy of his Psalterium, taking into account the context of Church history and the history of publishing Unitarian songbooks. In addition, the poetics of the two translations are analysed. Based on these it transpires that there were several circumstances that made the spreading of the Psalterium difficult.However, Thordai's work should not be viewed solely as depending on Bogáti's translation, since it is not certain that Thordai was trying to fill a gap with his translation. The Transylvanian Unitarians did not necessarily intend to publish a complete Unitarian translation of the Book of Psalms in their songbooks.
Evaluation of different phenotypic techniques in detection of metallo-betalactamases in pseudomonas aeruginosa
Authors: Mangla Aarushi , Vasani Hetal , Vegad M M 
Published: September 2022

Metallo-beta-lactamase (MBL) producing Pseudomonas is a worrisome pathogen to hospital infection control due to production of resistance to multiple antibiotics. So, treatment options are narrowed down to only few antibiotics which will result in high morbidity and mortality. This study was conducted with the aim to detect prevalence of MBL producing Pseudomonas aeruginosa and to compare the different phenotypic methods for the detection of MBL production in Imipenem resistant clinical isolates of Pseudomonas aeruginosa. : In this prospective study total of 14,145 different clinical samples received from different wards. Out of which 804 Pseudomonas aeruginosa were isolated and antibiotic sensitivity testing was done by Kirby-Bauer disc diffusion method using CLSI guidelines. These were evaluated for Carbapenems resistance and MBL production. Imipenem resistant strains were subjected to screening tests like Double-disc synergy test, Combined disc diffusion test (CDT) and Modified-Hodge test. : In our study out of 804 isolates,153(19.02%) isolates are resistant to Imipenem. Out of 153 Imipenem resistant isolates, Combined disc diffusion test was positive in 100%, Double disc synergy test in 76.5% and Modified-hodge test in 84.15% isolates.: Combined disc diffusion test is very sensitive, cost effective and convenient screening test for detection of MBL producing Pseudomonas aeruginosa. So, all Imipenem resistant Pseudomonas isolates should be regularly screened for detection of MBL by Combined disc diffusion test (CDT) to prevent spread of resistance, longer hospital stay and treatment failure.
Smooth and Rough Brucella Infections in Dogs
Authors: Arserim Neval Berrin , Gürbilek Sevil Erdenliğ , Keskin Oktay , Tel Yaşar , Doğan Elif 
Published: September 2022

Background: B. canis infections have been reported in many countries of the world. B.canis can cause infections both in dogs and human beings. It can be transmitted to human via laboratory accidents during handling and contact with sick dogs. is an infectious agent for humans and it is transmitted to humans by various ways including laboratory accidents and contact with sick dogs. Methods: In this study serum samples were collected by using stratified random sampling method from the Diyarbakýr Metropolitan Municipality Animal Care and Rehabilitation Center, where approximately 600 dogs were housed. Result: Out of 83 samples, 9.6% and 26.5% of serum samples were found as positive by B.canis RSAT and B.canis ELISA, respectively. While 6% and 9.6% of the samples were positive by B. abortus S99 RSAT and B. abortus ELISA, respectively. Sensitivity and specificity of B. abortus S99 ELISA was 98% and 95.5%, respectively. On the other hand, sensitivity and specificity of B.canis M(-) ELISA was 96.6% and 94%. As a result, it was concluded that B. canis infection is common in dogs and this should be considered both for dogs and public health. Unfortunately, there is no standardized commercial serological test for diagnosis of B.canis and other rough Brucella species currently. This is the main reason that rough brucella infections might not represent the real B.canis infection situation. Therefore, most of the cases have the possibility of being undetected. For this reason it is utmost important that B.canis RSAT and ELISA can be used as routine tests in the hospitals and veterinary clinics in the serological diagnosis of brucellosis.
Predictors of Women’s Childbirth Experience: A Prospective Longitudinal Study on Italian New Mothers
Authors: Molgora Sara , Campo Emanuela , Carones Maurizio Barbieri , Ferrazzi Enrico , Saita Emanuela , Facchin Federica 
Published: September 2022

BACKGROUNDWomen’s memories of their childbirth experience tend to remain unchanged over time. This experience can be influenced by obstetric factors as well as by sociodemographic and psychological variables.OBJECTIVETo examine whether women’s perceived childbirth experience changes over time; to identify the predictors (obstetric, sociodemographic, and psychological variables) of this experience immediately after delivery and after 3 months.METHODSThis prospective longitudinal study comprised two hundred and twenty-one Italian women who completed a self-report questionnaire at two assessment points: immediately (1–3 days) after birth (Time 1) and 3 months postpartum (Time 2). At Time 1, the questionnaire included some questions on sociodemographic, psychological, and obstetric information, and the Wijma Delivery Experience Questionnaire (WDEQ(B); at Time 2 women compiled again the WDEQ(B).RESULTSRepeated measures ANOVA revealed that the childbirth experience did not change from Time 1 to Time 2. However, predictors of this experience were different between Time 1 and Time 2: at Time 1, the childbirth experience (WDEQ(B)_t1) was significantly predicted nly by type of cesarean section; at Time 2, the childbirth experience (WDEQ(B)_t2) was significantly predicted by WDEQ(B)_t1, history of psychological disorders, and type of conception.DISCUSSIONSOur findings enhance the understanding of the main predictors of a woman’s childbirth experience. Identifying areas of vulnerability is important for clinical practice, as well as for developing maternal health policies to improve women’s birth experiences, postpartum well-being, and the baby’s development.
Does Childbirth Preparation Education Affect Prenatal Adaptation?
Authors: Uzun Aksoy Mehtap , Şentürk Erenel Ayten 
Published: September 2022

OBJECTIVETo determine the effect of childbirth preparation education on the prenatal adaptation of pregnant women.METHODSThis study design was a quasi-experimental; one-group pretest-posttest. This study was conducted with the participation of 42 pregnant women and their spouses. The educations were given in four sessions in a special area designed for childbirth preparation educations in a private hospital where the study was conducted. The data of the study were collected using the Pregnant Women Information Form and the Prenatal Self-Evaluation Questionnaire. Prenatal Self-Evaluation Questionnaire consists of seven subscales which are the well-being of pregnant women and their infants, acceptance of pregnancy, acceptance of motherhood, fear of childbirth, relationship with her mother and relationship with her spouse. The Wilcoxon signed rank test statistics were used to analyze the difference between the pretest and posttest PSEQ scores.RESULTSThe concerns about the well-being of pregnant women and their infants (p < .05), acceptance of pregnancy (p < .05), acceptance of motherhood (p < .05), fear of childbirth (p < .05), relationship with her mother (p < .05), relationship with her spouse (p < .05) subscale and total adaptation score (p < .05) were significantly higher before the education compared with the after the education. However, there was no significant difference between pre and post-education scores regarding readiness for birth subscale (p > .05).CONCLUSIONThis study showed that childbirth preparation education improves prenatal adaptation, acceptance of pregnancy and motherhood, relationship with her mother and relationship with her partner of pregnant women. In addition, it decreased fear of childbirth of pregnant women.
Correlations Between Primiparous Women’s Perceived Internal Control, External Control, Support and Their Birth Experience
Authors: Ghanbari-Homaie Solmaz , Meedya Shahla , Mohammad-Alizadeh-Charandabi Sakineh , Asghari Jafarabadi Mohammad , Mohammadi Eesa , Mirghafourvand Mojgan 
Published: September 2022

BACKGROUNDPerceived control and support can contribute to a positive childbirth experience. However, most studies have not differentiated between perceived internal and external control.OBJECTIVEThe present study aimed to assess primiparous women’s perceived internal control, external control, and support, including family and professional support and their association with the childbirth experience.METHODSA cross-sectional study was carried out on 800 primiparous mothers recruited from health centers across Tabriz, Iran, through cluster sampling. The childbirth experience questionnaire (2.0) and the support and control in birth scale were used to measure women’s childbirth experience and their perceived internal and external control and support. Data were collected through an interview during early postpartum and analyzed by independent t-test, one-way ANOVA, Pearson correlation and general linear model.RESULTSThe results demonstrated a significant correlation between perceived internal control (r = 0.80, p < .001), external control (r = 0.79, p < .001) and professional support (r = 0.83, p < .001) with childbirth experience. By controlling confounders such as socio-demographic and reproductive variables, internal control [β (95% CI): 0.28 (0.25 to 0.31); p < .001], external control [0.10 (0.06 to 0.14); p < .001], professional support [0.27 (0.23 to 0.30); p < .001], were independent predictors of positive childbirth experience.CONCLUSIONThese findings point to the importance of perceived internal, external control and professional support and the relationship between healthcare providers, especially midwives, with the women in improving childbirth experience. It is suggested that healthcare providers give support to women and utilize methods that enhance women’s control during labor and childbirth.
A deep learning model for detection of leukocytes under various interference factors
Authors: Li Meiyu , Li Lei , Song Shuang , Ge Peng , Zhang Hanshan , Lu Lu , Liu Xiaoxiang , Zheng Fang , Lin Cong , Zhang Shijie , Sun Xuguo 
Published: September 2022

Abstract
The accurate detection of leukocytes is the basis for the diagnosis of blood system diseases. However, current methods and instruments either fail to fully automate the identification process or have low performance. To improve the current status, we do need to develop more intelligent methods. In this paper, we investigate fulfilling high-performance automatic detection for leukocytes using a deep learning-based method. A complete working pipeline for building a leukocyte detector is presented, which includes data collection, model training, inference, and evaluation. We established a new leukocyte dataset that contains 6273 images (8595 leukocytes), considering nine common clinical interference factors. Based on the dataset, the performance evaluation of six mainstream detection models is carried out, and a more robust ensemble scheme is proposed. The mAP @IoU = 0.50:0.95 and mAR@IoU = 0.50:0.95 of the ensemble scheme on the test set are 0.853 and 0.922, respectively. The detection performance of poor-quality images is robust. For the first time, it is found that the ensemble scheme yields an accuracy of 98.84% for detecting incomplete leukocytes. In addition, we also compared the test results of different models and found multiple identical false detections of the models, then provided correct suggestions for the clinic.