bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autologous platelet‐rich plasma intrauterine perfusion to improve pregnancy outcomes after implantation failure: A systematic review and meta‐analysis
Authors: Liu Kepeng , Cheng Hui , Guo Yaqiong , Liu Yuan , Li Lifei , Zhang Xuehong 
Published: September 2022

AbstractAimsPrevious studies have reported inconsistent findings on the efficacy of platelet‐rich plasma (PRP) therapy in women with implantation failure. The objective of this review was to evaluate whether PRP administration could improve pregnancy outcomes in women with implantation failure undergoing in vitro fertilization.MethodsElectronic databases were searched for studies that explored the effects of PRP for patients with implantation failure. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Based on the available data, we performed subgroup analyses and sensitivity analyses.ResultsEight studies were included. PRP treatment improved pregnancy outcomes for all women compared with no treatment or placebo (clinical pregnancy rate: OR 2.24, 95% CI 1.41–3.54; live birth rate: OR 5.76, 95% CI 1.55–21.44; miscarriage rate: OR 0.18, 95% CI 0.05–0.63), especially in randomized controlled trials. No significant differences were detected in multiple pregnancy rates (OR 2.54, 95% CI 0.67–9.67). Furthermore, subgroup analysis based on the number of previous implantation failures showed that PRP treatment improved pregnancy outcomes in women with recurrent implantation failure (clinical pregnancy rate: OR 2.55, 95% CI 1.49–4.38; live birth rate: OR 5.07, 95% CI 1.15–22.34; miscarriage rate: OR 0.20, 95% CI 0.05–0.78).ConclusionPRP administration could improve pregnancy outcomes in women with recurrent implantation failure. Due to the limited evidence available, the efficacy of PRP in women with recurrent implantation failure needs to be further verified in high‐quality studies with larger sample sizes.
Experiments on the reactivity of basaltic minerals and glasses in Venus surface conditions using the Glenn Extreme Environment Rig
Authors: Radoman‐Shaw Brandon G. , Harvey Ralph P. , Costa Gustavo , Jacobson Nathan S. , Avishai Amir , Nakley Leah M. , Vento Daniel 
Published: September 2022

AbstractClimate models for Venus rely heavily on theoretical modeling and laboratory experimentation due to the extreme surface conditions of the planet and limited in situ surface data. To better explore the relative importance of reactions between the surface and the atmosphere on Venus, we exposed representative volcanic glasses and basaltic minerals to a large‐scale simulation of Venus surface conditions with a realistic atmospheric composition. This study consistend of two experiments of 42 and 80 days that replicated both physical conditions and atmosphere composition derived from available in situ near‐surface data using the Glenn Extreme Environment Rig (GEER) at the NASA Glenn Research Center. These experiments revealed significant reactivity of common Ca‐bearing pyroxenes (diopside and augite) to form anhydrite. Olivine and labradorite showed minimal reactivity. Volcanic glasses, including both natural and synthetic samples, were exceptionally reactive, rapidly forming both anhydrite and thénardite (Na2SO4), as well as transition metal sulfates (i.e., Cu, Cr), halite (NaCl), and sylvite (KCl). Our results document chemical and textural alteration of sample surfaces and provide sufficient evidence for an active sulfur sink on multiple samples, with sulfates as the dominant secondary mineralogy. These experiments suggest likely surface mineralogies and solid phases present on Venus' surface with significant implications for upcoming missions and provide new data for comparison to high‐temperature mineral–gas reactions prevalent on Venus, Earth, and Io.
Maize cytosolic invertase INVAN6 ensures faithful meiotic progression under heat stress
Authors: Huang Wei , Li Yunfei , Du Yan , Pan Lingling , Huang Yumin , Liu Hongbing , Zhao Yue , Shi Yunlu , Ruan Yong‐Ling , Dong Zhaobin , Jin Weiwei 
Published: September 2022

Summary

Faithful meiotic progression ensures the generation of viable gametes. Studies suggested the male meiosis of plants is sensitive to ambient temperature, but the underlying molecular mechanisms remain elusive.

Here, we characterized a maize (Zea mays ssp. mays L.) dominant male sterile mutant Mei025, in which the meiotic process of pollen mother cells (PMCs) was arrested after pachytene.

An Asp‐to‐Asn replacement at position 276 of INVERTASE ALKALINE NEUTRAL 6 (INVAN6), a cytosolic invertase (CIN) that predominantly exists in PMCs and specifically hydrolyses sucrose, was revealed to cause meiotic defects in Mei025. INVAN6 interacts with itself as well as with four other CINs and seven 14‐3‐3 proteins. Although INVAN6Mei025, the variant of INVAN6 found in Mei025, lacks hydrolytic activity entirely, its presence is deleterious to male meiosis, possibly in a dominant negative repression manner through interacting with its partner proteins. Notably, heat stress aggravated meiotic defects in invan6 null mutant. Further transcriptome data suggest INVAN6 has a fundamental role for sugar homeostasis and stress tolerance of male meiocytes.

In summary, this work uncovered the function of maize CIN in male meiosis and revealed the role of CIN‐mediated sugar metabolism and signalling in meiotic progression under heat stress.
The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large‐scale resting‐state functional brain networks in aging
Authors: Deery Hamish A. , Di Paolo Robert , Moran Chris , Egan Gary F. , Jamadar Sharna D. 
Published: September 2022

AbstractThe literature on large‐scale resting‐state functional brain networks across the adult lifespan was systematically reviewed. Studies published between 1986 and July 2021 were retrieved from PubMed. After reviewing 2938 records, 144 studies were included. Results on 11 network measures were summarized and assessed for certainty of the evidence using a modified GRADE method. The evidence provides high certainty that older adults display reduced within‐network and increased between‐network functional connectivity. Older adults also show lower segregation, modularity, efficiency and hub function, and decreased lateralization and a posterior to anterior shift at rest. Higher‐order functional networks reliably showed age differences, whereas primary sensory and motor networks showed more variable results. The inflection point for network changes is often the third or fourth decade of life. Age effects were found with moderate certainty for within‐ and between‐network altered patterns and speed of dynamic connectivity. Research on within‐subject bold variability and connectivity using glucose uptake provides low certainty of age differences but warrants further study. Taken together, these age‐related changes may contribute to the cognitive decline often seen in older adults.
Bacterial killing activity and lysozymes: A stable defence mechanism in stallion seminal plasma?
Authors: Jakop Ulrike , Hensel Britta , Czirják Gábor. Á. , Quirino Monike , Schröter Filip , Jung Markus , Schulze Martin 
Published: September 2022

AbstractDuring insemination, bacterial contamination of the ejaculate can lead to reduced sperm quality and transmission of pathogens to the female, thus should be avoided. The semen of a variety of animal taxa possess antimicrobial properties against a wide range of bacterial species through antimicrobial molecules, such as lysozyme, but their variance and the factors influencing it are unknown for most species. In this study, the antibacterial defence (bacterial killing activity (BKA) against Escherichia (E.) coli and Staphylococcus (S.) aureus as well as lysozyme concentration) was studied in seminal fluid from two consecutive ejaculates of 18 stallions. All ejaculates showed BKA against the tested bacteria, which correlated between the two consecutive ejaculates (rS = 0.526, p = .025 for E. coli and rS = 0.656, p = .003 for S. aureus) and appeared to be stable over the tested period. The lysozyme concentration (LC) showed no significant correlation between the consecutive ejaculates (rS = 0.161, p = .681). However, LC had a positive correlation to the ratio of apoptotic spermatozoa within the ejaculates (rS = 0.426, p = .019). In contrast to other livestock (e.g., boar, bull), the BKA in stallion semen did not correlate significantly with the age of the animal nor sperm quality characteristics.
N‐terminal domain of ARF‐GEF GNOM prevents heterodimerization with functionally divergent GNL1 in Arabidopsis
Authors: Brumm Sabine , Singh Manoj K. , Kriechbaum Choy , Richter Sandra , Huhn Kerstin , Kucera Tim , Baumann Sarah , Wolters Hanno , Takada Shinobu , Jürgens Gerd 
Published: September 2022

SUMMARYEvolutionary change following gene duplication can lead to functionally divergent paralogous proteins. If comprising identical subunits their random assortment would also form potentially detrimental heteromeric proteins. In Arabidopsis, the ARF GTPase guanine‐nucleotide exchange factor GNOM is essential for polar recycling of auxin‐efflux transporter PIN1 from endosomes to the basal plasma membrane whereas its paralog GNL1 mediates retrograde Golgi‐endoplasmic reticulum traffic. Here we show that both GNOM and GNL1 form homodimers but no heterodimers. To assess the biological significance of this, we generated transgenic plants expressing engineered heterodimer‐compatible GNOM variants. Those plants showed developmental defects such as the failure to produce lateral roots. To identify mechanisms underlying heterodimer prevention, we analyzed interactions of the N‐terminal dimerization and cyclophilin‐binding (DCB) domain. Each DCB domain interacted with the complementary fragment (ΔDCB) both of their own and of the paralogous protein. However, only DCBGNOM interacted with itself whereas DCBGNL1 failed to interact with itself and with DCBGNOM. GNOM variants in which the DCB domain was removed or replaced by DCBGNL1 revealed a role for DCB‐DCB interaction in the prevention of GNOM‐GNL1 heterodimers whereas DCB‐ΔDCB interaction was essential for dimer formation and GNOM function. Our data suggest a model of early DCB‐DCB interaction that facilitates GNOM homodimer formation, indirectly precluding formation of detrimental heterodimers.
The efficacy of subcutaneous slow‐release melatonin implants in the prevention of canine flank alopecia recurrence is uncertain: A double‐blind, randomized, placebo‐controlled study
Authors: Verschuuren Millie U. M. Y. , Schlotter Yvette M. , van Geijlswijk Inge M. , van der Lugt Jaco J. , Gehring Ronette 
Published: September 2022

AbstractBackgroundCanine flank alopecia (CFA) is characterized by seasonally recurring noninflammatory, occasionally hyperpigmented alopecia predominantly in the thoracolumbar area. Previous studies suggest that reduced production of endogenous melatonin may play a role in the pathogenesis of this condition, and placebo‐controlled studies on the efficacy of preventative melatonin treatment are lacking.ObjectiveTo evaluate the efficacy of subcutaneous slow‐release melatonin implants in the prevention of CFA recurrence.AnimalsTwenty‐one client‐owned dogs with a history of CFA were included in the study.Materials and MethodsAt time (T)0, a general physical and dermatological examination was performed on each dog, blood was collected for serum biochemistry analysis and two skin biopsies were taken from alopecic areas on the nonsedated affected dogs after subcutaneous injection with 2% lidocaine. Dogs with normal blood work and histological results compatible with CFA were included in the study. Participating dogs were randomly assigned to receive either placebo or 18 mg melatonin subcutaneously in the interscapular area, approximately 2 months before expected CFA onset (T1). CFA recurrence was scored qualitatively as complete, ≤50% recurrence, or no recurrence at 5 and 7 months after the intervention (T2 and T3, respectively).ResultsAt T3, in dogs treated with placebo (nine of 17), the percentages for complete recurrence, ≤50% recurrence and no recurrence were 44%, 0% and 56%, respectively. In dogs treated with melatonin (eight of 17), these percentages were 25%, 50% and 25%, respectively. There were no statistically significant differences in the scores between melatonin‐treated dogs and placebo‐treated dogs (p = 0.40). In three of eight melatonin‐treated dogs, mild transient swelling was observed at the injection site.ConclusionsThis study did not provide evidence that an 18 mg melatonin implant treatment, although well‐tolerated, is efficacious in preventing recurrence of CFA in affected dogs.
Exploring Visual Cues for Design Analogy: A Deep Learning Approach
Authors: Zhang Zijian , Jin Yan 
Published: September 2022

Abstract
The goal of this research is to develop a computer-aided visual analogy support (CAVAS) framework to augment designers’ visual analogical thinking by stimulating them by providing relevant visual cues from a variety of categories. Two steps are taken to reach this goal: developing a flexible computational framework to explore various visual cues, i.e., shapes or sketches, based on the relevant datasets and conducting human-based behavioral studies to validate such visual cue exploration tools. This article presents the results and insights obtained from the first step by addressing two research questions: How can the computational framework CAVAS be developed to provide designers in sketching with certain visual cues for stimulating their visual thinking process? How can a computation tool learn a latent space, which can capture the shape patterns of sketches? A visual cue exploration framework and a deep clustering model CAVAS-DL are proposed to learn a latent space of sketches that reveal shape patterns for multiple sketch categories and simultaneously cluster the sketches to preserve and provide category information as part of visual cues. The distance- and overlap-based similarities are introduced and analyzed to identify long- and short-distance analogies. Performance evaluations of our proposed methods are carried out with different configurations, and the visual presentations of the potential analogical cues are explored. The results have demonstrated the applicability of the CAVAS-DL model as the basis for the human-based validation studies in the next step.
Evolution of the Bronson Hill arc and Central Maine basin, northern New Hampshire to western Maine: U-Pb zircon constraints on the timing of magmatism, sedimentation, and tectonism
Authors: Eusden* J. Dykstra , Hillenbrand† Ian W. , Folsom Elizabeth , Merrill Thorn , Niiler Kurt , Wheatcroft Audrey 
Published: September 2022

ABSTRACTThe Ordovician Bronson Hill arc and Silurian–Devonian Central Maine basin are integral tectonic elements of the northern Appalachian Mountains (USA). However, understanding the evolution of, and the relationship between, these two domains has been challenging due to complex field relationships, overprinting associated with multiple phases of Paleozoic orogenesis, and a paucity of geochronologic dates. To constrain the nature of this boundary, and the tectonic evolution of the northern Appalachians, we present U-Pb zircon dates from 24 samples in the context of detailed mapping in northern New Hampshire and western Maine. Collectively, the new geochronology and mapping results constrain the timing of magmatism, sedimentation, metamorphism, and deformation. The Bronson Hill arc formed on Gondwana-derived basement and experienced prolonged magmatic activity before and after a ca. 460 Ma reversal in subduction polarity following its accretion to Laurentia in the Middle Ordovician Taconic orogeny. Local Silurian deformation between ca. 441 and 434 Ma may have been related to the last stages of the Taconic orogeny or the Late Ordovician to early Silurian Salinic orogeny. Silurian Central Maine basin units are dominated by local, arc-derived zircon grains, suggestive of a convergent margin setting. Devonian Central Maine basin units contain progressively larger proportions of older, outboard, and basement-derived zircon, associated with the onset of the collisional Early Devonian Acadian orogeny at ca. 410 Ma. Both the Early Devonian Acadian and Middle Devonian to early Carboniferous Neoacadian orogenies were associated with protracted amphibolite-facies metamorphism and magmatism, the latter potentially compatible with the hypothesized Acadian altiplano orogenic plateau. The final configuration of the Jefferson dome formed during the Carboniferous via normal faulting, possibly related to diapirism and/or ductile thinning and extrusion. We interpret the boundary between the Bronson Hill arc and the Central Maine basin to be a pre-Acadian normal fault on which dip was later reversed by dome-stage tectonism. This implies that the classic mantled gneiss domes of the Bronson Hill anticlinorium formed relatively late, during or after the Neoacadian orogeny, and that this process may have separated the once-contiguous Central Maine and Connecticut Valley basins.
Is rehabilitation effective in preventing decreased functional status after community-acquired pneumonia in elderly patients? Results from a multicentre, retrospective observational study
Authors: Chen Hao , Hara Yu , Horita Nobuyuki , Saigusa Yusuke , Hirai Yoshihiro , Kaneko Takeshi 
Published: September 2022

ObjectivesThis study was designed to evaluate the effect of rehabilitation in preventing decreased functional status (FS) after community-acquired pneumonia (CAP) in elderly patients.DesignThis was a retrospective observational study.SettingMulticentre study was conducted in two medical facilities from January 2016 to December 2018.ParticipantsHospitalised patients with CAP aged over 64 years were enrolled. FS was assessed by the Barthel Index (BI) (range, 0–100, in 5-point increments) at admission and before discharge and graded into three categories: independent, BI 80–100; semidependent, BI 30–75; and dependent, BI 0–25. Multivariable analysis of factors contributing to decreased FS was conducted with two groups: with a decrease of at least one category (decreased group) or without a decrease of category (maintained group).Primary and secondary outcome measuresThe primary outcome was the effect of rehabilitation in preventing decreased FS. The secondary outcomes were factors associated with decreased FS.ResultsThe maintained and decreased groups included 400 and 138 patients, respectively. A high frequency of rehabilitation therapy was observed in the decreased group (189 (47.3%) vs 104 (75.4%); p<0.001). Multivariable analysis showed that the factors affecting FS were aspiration pneumonia, Pneumonia Severity Index (PSI) category V, length of stay and age (OR 2.66, 95% CI 1.58 to 4.49; OR 1.92, 95% CI 1.29 to 3.44; OR 1.05, 95% CI 1.04 to 1.07; and OR 1.05, 95% CI 1.02 to 1.09, respectively). After adjusting for factors contributing to decreased FS, rehabilitation showed a limited effect in preventing decreased FS in 166 matched pairs by McNemar’s test (p=0.327).ConclusionsAspiration and PSI played important roles in reducing FS. The effect of rehabilitation remains unclear in CAP.Trial registration numberUMIN000046362.
Treatment of periprosthetic joint infections guided by minimum biofilm eradication concentration (MBEC) in addition to minimum inhibitory concentration (MIC): protocol for a prospective randomised clinical trial
Authors: Tillander Jonatan A N , Rilby Karin , Svensson Malchau Karin , Skovbjerg Susann , Lindberg Erika , Rolfson Ola , Trobos Margarita 
Published: September 2022

IntroductionProsthetic joint infections (PJIs) are disastrous complications for patients and costly for healthcare organisations. They may promote bacterial resistance due to the extensive antibiotic use necessary in the PJI treatment. The PJI incidence is estimated to be 1%–3%, but the absolute numbers worldwide are high and increasing as large joint arthroplasties are performed by the millions each year. Current treatment algorithms, based on implant preserving surgery or full revision followed by a semitailored antibiotic regimen for no less than 2–3 months, lead to infection resolution in approximately 60% and 90%, respectively. Antibiotic choice is currently guided by minimum inhibitory concentrations (MICs) of free-living bacteria and not of bacteria in biofilm growth mode. Biofilm assays with relatively rapid output for the determination of minimum biofilm eradication concentrations (MBECs) have previously been developed but their clinical usefulness have not been established.Methods and analysisThis single-blinded, two-arm randomised study of hip or knee staphylococcal PJI will evaluate 6-week standard of care (MIC guided), or an alternative antibiotic regimen according to an MBEC-guided-based decision algorithm. Sixty-four patients with a first-time PJI treated according to the debridement, antibiotics, and implant retention principle will be enrolled at a single tertiary orthopaedic centre (Sahlgrenska University Hospital). Patients will receive 14 days of standard parenteral antibiotics before entering the comparative study arms. The primary outcome measurement is the proportion of changes in antimicrobial regimen from first-line treatment dependent on randomisation arm. Secondary endpoints are unresolved infection, how microbial properties including biofilm abilities and emerging antimicrobial resistance correlate to infection outcomes, patient reported outcomes and costs with a 12-month follow-up.Ethics and disseminationApproval is received from the Swedish Ethical Review Authority, no 2020-01471 and the Swedish Medical Products Agency, EudraCT, no 2020-003444-80.Trial registration numberClinicalTrials.gov ID:NCT04488458.