bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENYULUHAN PEMANFAATAN LINGKUNGAN MASA PANDEMI UNTUK BUDIDAYA TANAMAN HERBAL DI SMAN 65 JAKARTA
Authors: Setiawan Eko Adhy , Budiyanti Rully Besari , Supriyatna Yayat , Syabilla Ovia 
Published: May 2022

AbstractA new regular life change has occurred in the school environment. Teachers must be able to set an example to implement healthy behaviour, especially during a pandemic. The school environment has a significant role in changing health behaviour. The purpose of the service is to apply knowledge and provide education to educators, students, and school managers to cultivate herbal plants in the school environment in realizing the health of the school environment during the pandemic. The method used in implementing this service activity is the lecture method by providing counselling about the use of the school environment for the cultivation of herbal plants at the 65 Jakarta State Senior High School. The service results showed that the service activities at the 65 Jakarta State Senior High School were running smoothly, and the counselling took place online. This service activity will increase knowledge, insight, and educators, students, and school managers can understand the importance of implementing the school environment for cultivating herbal plants in realizing healthy behaviour changes during a pandemic. AbstrakPerubahan kehidupan normal yang baru ada pada lingkungan sekolah. Guru-guru harus bisa memberikan teladan agar bisa menerapkan perilaku sehat, terutama di masa pandemik. Lingkungan sekolah mempunyai andil yang cukup besar dalam mengubah perilkau sehat. Adapun tujuan pengabdian adalah menerapkan pengetahuan dan memberikan edukasi kepada para pendidik, peserta didik dan pengelola sekolah untuk dibudidayakan tanaman herbal di lingkungan sekolah dalam mewujudkan kesehatan lingkungan sekolah masa pandemi. Metode yang digunakan dalam pelaksanaan kegiatan pengabdian ini adalah metode ceramah dengan memberikan penyuluhan tentang pemanfaatan lingkungan sekolah untuk budidaya tanaman herbal di Sekolah Menengah Atas Negeri 65 Jakarta. Hasil pengabdian menunjukkan bahwa kegiatan pengabdian di Sekolah Menengah Atas Negeri 65 Jakarta berjalan lancar dan penyuluhan berlangsung secara daring. Kegiatan pengabdian ini akan meningkatkan pengetahuan, wawasan dan pendidik, peserta didik serta pengelola sekolah mampu memahami pentingnya penerapan lingkungan sekolah untuk budidaya tanaman herbal dalam mewujudkan perubahan perilaku sehat dalam masa pendemik.
ДЕПРИВАЦІЯ ВІЙСЬКОВОСЛУЖБОВЦІВ, ЯКІ ВИКОНУЮТЬ ЗАВДАННЯ У ВІДРИВІ ВІД ОСНОВНИХ СИЛ, ТА В УМОВАХ ПОЛОНУ
Authors: Красницька О. 
Published: May 2022

Стаття присвячена проблемі впливу депривації на психіку й особистість військовослужбовців, які виконують завдання у відриві від основних сил, та в умовах полону. З’ясовано особливості впливу психічної, сенсорної, когнітивної, емоційної, депривації сну, сімейної, екзистенційної депривації.
Визначено зовнішні та внутрішні деприваційні фактори, що чинять негативний вплив на військовослужбовця в екстремальних умовах діяльності. До зовнішніх факторів належать ізоляція, відсутність належних соціально-побутових умов, невизначеність і небезпека, швидкоплинність змін бойової обстановки, обмеження в часовому еквіваленті, високий ступінь ризику, новизна бойової обстановки, недовіра в ланці субординації згори – донизу та знизу – догори. Серед внутрішніх деприваційних факторів виділено високий рівень амбівалентності та сумніву, виражені ананкастичні властивості, схильність до сугестії, високий рівень тривожності й низький рівень стресостійкості, невміння бачити картину в цілому, відсутність попереднього досвіду бойових дій або негативний попередній досвід, низький рівень критичного та креативного мислення.
Fabrication and Effect of Strontium-Substituted Calcium Silicate/Silk Fibroin on Bone Regeneration In Vitro and In Vivo
Authors: Zhou Yuning , Hu Yue , Uemura Mamoru , Xia Lunguo , Yu Xingge , Xu Yuanjin 
Published: May 2022

Achieving rapid osteogenesis and angiogenesis was the key factor for bone regeneration. In the present study, the strontium-substituted calcium silicate (SrCS)/silk fibroin (SF) composite materials have been constructed by combining the different functional component ratios of SrCS (12.5 wt%, 25 wt%) and SF. Then, the effects of SrCS/SF materials on proliferation, osteogenic differentiation, and angiogenic factor secretion of rat bone marrow-derived mesenchymal stromal cells (rBMSCs) were first evaluated in vitro. Moreover, the in vivo effect of osteogenesis was evaluated in a critical-sized rat calvarial defect model. In vitro studies showed that SrCS/SF significantly enhanced the cell proliferation, alkaline phosphatase (ALP) activity, and the expression of osteogenic and angiogenic factors of rBMSCs as compared with the SF and CS/SF, and the optimum proportion ratio was 25 wt%. Besides, the results also showed that CS/SF achieved enhanced effects on rBMSCs as compared with SF. The in vivo results showed that 25 wt% SrCS/SF could obviously promote new bone formation more than SF and CS/SF. The present study revealed that SrCS could significantly promote the osteogenic and angiogenic activities of SF, and SrCS/SF might be a good scaffold material for bone regeneration.
Intelligent Fall-Risk Assessment Based on Gait Stability and Symmetry Among Older Adults Using Tri-Axial Accelerometry
Authors: Lien Wei-Chih , Ching Congo Tak-Shing , Lai Zheng-Wei , Wang Hui-Min David , Lin Jhih-Siang , Huang Yen-Chang , Lin Feng-Huei , Wang Wen-Fong 
Published: May 2022

This study aimed to use the k-nearest neighbor (kNN) algorithm, which combines gait stability and symmetry derived from a normalized cross-correlation (NCC) analysis of acceleration signals from the bilateral ankles of older adults, to assess fall risk. Fifteen non-fallers and 12 recurrent fallers without clinically significant musculoskeletal and neurological diseases participated in the study. Sex, body mass index, previous falls, and the results of the 10 m walking test (10 MWT) were recorded. The acceleration of the five gait cycles from the midsection of each 10 MWT was used to calculate the unilateral NCC coefficients for gait stability and bilateral NCC coefficients for gait symmetry, and then kNN was applied for classifying non-fallers and recurrent fallers. The duration of the 10 MWT was longer among recurrent fallers than it was among non-fallers (p &lt; 0.05). Since the gait signals were acquired from tri-axial accelerometry, the kNN F1 scores with the x-axis components were 92% for non-fallers and 89% for recurrent fallers, and the root sum of squares (RSS) of the signals was 95% for non-fallers and 94% for recurrent fallers. The kNN classification on gait stability and symmetry revealed good accuracy in terms of distinguishing non-fallers and recurrent fallers. Specifically, it was concluded that the RSS-based NCC coefficients can serve as effective gait features to assess the risk of falls.
Elevated ACE Levels Indicate Diabetic Nephropathy Progression or Companied Retina Impaired
Authors: Huang Kangkang , Liang Yunlai , Wang Kun , Ma Yating , Wu Jiahui , Luo Huidan , Yi Bin 
Published: May 2022

ObjectivesRenin-angiotensin-aldosterone system plays important roles in the development of diabetic nephropathy (DN), and angiotensin converting enzyme (ACE) is the key factor in the process from angiotensin I to angiotensin II, but the variation and roles of serum ACE in DN patients are still unclear.MethodsForty-four type 2 diabetes mellitus (T2DM) patients, 75 DN patients, and 36 age-gender-matched healthy volunteers were recruited who attended Xiangya Hospital of Central South University in this case control study. Serum ACE levels and other indexes were tested with commercial kit.ResultsACE levels in DN were significantly higher than T2DM and controls (F = 9.66, P &lt; 0.001). Serum ACE levels significantly correlated with UmALB (r = 0.3650, P &lt; 0.001), BUN (r = 0.3102, P &lt; 0.001), HbA1c (r = 0.2046, P = 0.0221), ACR (r = 0.4187, P &lt; 0.001), ALB (r = -0.1885, P = 0.0192), and eGFR (r = -0.3955, P &lt; 0.001), and we got an equation that Y = 2.839 + 0.648X1 + 2.001X2 + 0.003X3 - 6.637X4 +0.416X5 - 0.134X6 (Y: ACE; X1: BUN; X2: HbA1C; X3: UmALB; X4: gender; X5: ALB; X6: eGFR, R2 = 0.655). When DN patients were divided into advanced-stage and early-stage with or without DR, ACE levels would increase when early-stage DN develops into advanced-stage or companied with DR.ConclusionElevated serum ACE levels may hint DN progression or retina impaired of DN patients.
The Design of a Remediation Device for Heavy Metal Contaminated Soil Under Digital Economy
Authors: Li Yuanyuan , Liu Jiang , Jia Shibo 
Published: May 2022

Since entering the new era, the economy has grown rapidly and the economic strength has improved significantly, but it is accompanied by resource and environmental problems caused by the high pollution and high energy consumption growth model. Realizing the transformation of economic development from “incremental” to “increasing quality” and promoting economic green transformation has become one of the main development goals of China in the next stage. With the rapid development of China’s social economy, the changes of industrialization, urbanization and agricultural intensification are getting faster and faster. The discharge of industrial “three wastes” and urban domestic wastewater has gradually increased, and a large amount of chemical fertilizers and pesticides have been applied to rural arable land. It accelerates soil heavy metal pollution. Electrodynamic remediation technology, as an emerging soil in situ remediation technology, has attracted wide attention due to its advantages of wide range of pollutant removal, low cost and good effect. In this paper, a remediation device for heavy metal-contaminated soil is designed based on electrodynamic remediation technology. That is, on the basis of the digital economy, an electrolyte circulation mechanism with high adsorption of heavy metal ions is introduced. In this paper, the feasibility of electrokinetic remediation of the contaminated soil was investigated, and the effects of electrolyte type, voltage, and remediation time on the removal of heavy metals were studied. The following results were obtained through a series of experimental studies: the pH values of region A in E1, E2, and E3 were 3.24, 3.18, and 3.09, respectively. The current peak values of E1, E2 and E4 are 0.44, 0.68 and 0.75 mA respectively. E4 had the best adsorption effect on heavy metal cadmium ions, with an average adsorption rate of 7.3%. The results show that the electrodynamic remediation device can effectively remove heavy metals in soil. It can also recycle the electrolyte solution, which is an environmentally friendly repair device.
Energy and Exergy Analysis on a Novel Solar-Air Dual-Source Vapor Injection Heat Pump Air-Conditioner for the Electric Bus
Authors: Zhang Hong , Liu Qian , Yang Lichen 
Published: May 2022

A novel solar-air dual-source vapor injection heat pump air-conditioner for the electric bus is proposed, aiming to enhance the system heating performance and increase the vehicle endurance. Three working modes are designed for the proposed system, including solar-air dual-source heating mode, air source heating mode, and cooling mode. The system heating performance is explored by the simulation approach. Compared with the conventional vapor injection heat pump, the proposed system averagely enlarges the heating capacity and efficiency by 17.0% and 21.2%, respectively, under the considered evaporating temperature range (−25∼0°C) by utilizing the solar energy. Moreover, the two systems possess the optimal intermediate pressures to achieve the maximal heating efficiency. The system performance comparison under the two heating modes indicates that the dual-source mode is preferred except for the extremely low or no solar radiation situation. The exergy analysis shows that more than half of the system total exergy input is destructed in the solar collector, which grows by 111.4% as the solar radiation intensity increases by 300 W m−2; thus, the system exergy efficiency decreases as the solar radiation enhances, although the system heat exergy output shows a growth tendency. The component irreversibility analysis on the proposed system is also conducted, aiming to explore the reason for the system exergy performance variation and the irreversibility distribution rule. At last, the exergy flow situations of the proposed system and the conventional system are contrastively analyzed. The exergy performance comparison indicates that under the given condition the proposed system can improve the exergy output by 20.2% and decrease the electricity consumption by 4.5% compared with the conventional system.
rs401502 and rs11575934 Polymorphisms of the IL-12 Receptor Beta 1 Gene are Protective Against Colorectal Carcinogenesis
Authors: Jelassi Refka , Dhouioui Sabrine , Ben Salah Hamza , Saidi Nasreddine , Mzoughi Nabiha , Ammi Radhia , Bouratbine Aida , Aoun Karim , Zidi Ines , Chelbi Hanen 
Published: May 2022

Background: Colorectal cancer (CRC) is a major public health problem worldwide and in Tunisia. It ranks among the main cancers in terms of incidence and cancer-related cause of death. Its pathogenesis is currently considered to be multifactorial involving genetic and environmental factors. Recent studies have suggested that the gene encoding the β1 subunit of the IL-12 receptor, an important pro-inflammatory cytokine of the anti-tumor response, could be involved in the susceptibility to inherited CRC. Hence, it would be interesting to study the role of single nucleotide polymorphisms (SNPs) within the IL-12RB1 gene (rs401502 and rs11575934) in CRC susceptibility.Aim: Our purpose was to assess whether genetic variants IL-12RB1 +1196G/C (rs401502) and IL-12RB1 +705A/G (rs11575934) within the IL-12RB1 gene are associated with the sporadic CRC risk.Methods: A total of 110 Tunisian patients with sporadic CRC and 141 healthy control subjects were included in this study. Genotyping was performed by high-resolution melting (HRM) analysis. All results were confirmed by direct DNA sequencing or PCR-RFLP methods. Later, the allele frequencies and genotype distribution were established and compared between the control group and CRC patients.Results: The obtained results showed that the two target SNPs were in Hardy–Weinberg equilibrium (HWE) in both patients and controls. Minor allele frequencies of rs401502 SNP were 16.4% in CRC cases and 23.8% in controls. Mutant allele of rs11575934 SNP was present with 21.4% in CRC patients and 29.8% in control group. An association study showed a significant association of two target polymorphisms with CRC, according to the dominant genetic model with OR = 0.577, 95% CI = [0.343 to 0.972], p = 0.038 and OR = 0.547, 95% CI = [0.328 to 0.911], p = 0.02, respectively.Conclusion: In this study, we found, for the first time, a potential protective effect of two SNPs in the IL-12RB1 gene, namely rs401502 and rs11575934, in sporadic colorectal cancer in Tunisians.
Transcriptomic Analysis Reveals Endometrial Dynamics in Normoweight and Overweight/Obese Polycystic Ovary Syndrome Women
Authors: Liu Su , Hong Ling , Lian Ruochun , Xiao Shan , Li Yuye , Diao Lianghui , Zeng Yong 
Published: May 2022

The aim of this work was to identify the transcriptomic characteristics of the endometrium in normoweight and overweight/obese polycystic ovary syndrome (PCOS) potentially underlying the pathogenesis. This study included 38 patients undergoing in vitro fertilization: 22 women with PCOS and 16 matched controls. Each of the groups was subdivided into normoweight (body mass index (BMI) &lt; 25 kg/m2) and overweight/obese (BMI ≥25 kg/m2) subgroups. Endometrium samples were collected in the secretory phase from controls or in a modeled secretory phase using daily administration of progesterone from women with PCOS before in vitro fertilization treatment. Transcriptome profiles were assessed by high-throughput RNA sequencing to investigate distinct endometrial gene expression patterns in PCOS. Bioinformatics analyses revealed that the endometrium from PCOS expresses significantly different transcripts encoding endometrial receptivity, inflammatory response, angiogenesis, and energy metabolism. Additionally, our study demonstrated that the differentially expressed genes between normoweight and overweight/obese PCOS are involved in fatty acid metabolism, endometrial decidualization, and immune response. For the first time, we have described the transcriptome characteristics of normoweight and overweight/obese PCOS endometria. Our results indicate different endometrial gene expressions between different subtypes of PCOS and non-PCOS women, which might affect endometrial functions in PCOS patients.
Identifying and Exploring the Candidate Susceptibility Genes of Cirrhosis Using the Multi-Tissue Transcriptome-Wide Association Study
Authors: Zhu Xiao-Bo , Hou Yu-Qing , Ye Xiang-Yu , Zou Yi-Xin , Xia Xue-Shan , Yang Sheng , Huang Peng , Yu Rong-Bin 
Published: May 2022

Objective: We identify and explore the candidate susceptibility genes for cirrhosis and their underlying biological mechanism.Methods: We downloaded the genome-wide association studies summary data of 901 cirrhosis cases and 451,363 controls and integrated them with reference models of five potential tissues from the Genotype-Tissue Expression (GTEx) Project, including whole blood, liver, pancreas, spleen, and thyroid, to identify genes whose expression is predicted to be associated with cirrhosis. Then, we downloaded gene expression data of individuals with hepatocellular carcinoma from TCGA database to conduct differential expression analysis to validate these identified genes and explored their possible role in driving cirrhosis via functional enrichment and gene set enrichment analysis (GSEA).Results: We identified 10 significant genes (SKIV2L, JPH4, UQCC2, RP11-91I8.3, MAU2, ERAP1, PUS3, ZNF677, ARHGAP40, and SHANK3) associated with cirrhosis at a Bonferroni-corrected threshold of p &lt; 0.01, among which two (SKIV2L and JPH4) were identified in the liver and five (SKIV2L, JPH4, MAU2, SHANK3, and UQCC2) were validated by differential expression analysis at an FDR-corrected threshold of p &lt; 0.01. The enrichment analysis showed that the degradation process of RNA, which is enriched by 58 genes, is significantly under-enriched in liver cancer tissues (p = 0.0268).Conclusion: We have identified several candidate genes for cirrhosis in multiple tissues and performed differential genetic analysis using the liver cancer database to verify the significant genes. We found that the genes SKIV2L and JPH4 identified in the liver are of particular concern. Finally, through enrichment analysis, we speculate that the process of mRNA transcription and RNA degradation may play a role in cirrhosis.
A Toolbox for Constructing a Stable Genetic Transformation Platform Allowing Foreign Fragment Integration in the Genome of Neopyropia yezoensis
Authors: Cao Xuexue , Kong Fanna , Sun Bin , Yin Jiqiang , Ren Hongzhong , Yue Huijie , Yu Chenggong , Tang Xianghai , Du Guoying , Wang Dongmei , Mao Yunxiang 
Published: May 2022

Neopyropia yezoensis, previously known as Pyropia yezoensis, is regarded as a model macroalgae because of its economic value and typical intertidal seaweed species. However, the genetic transformation system to introduce foreign genes into its cells is inefficient and not stable. This study developed a more efficient transformation toolbox that allows the stable expression of foreign genes in N. yezoensis cells. We constructed an efficient transformation platform with the parameters of biolistic bombardment of 6 cm target distance, 600 μg gold particles/shot, 10 μg plasmid DNA/shot, 1,350 psi of helium, and 30 mmHg vacuum pressure. Thalli at 35 days of age were the most suitable transformation conditions, in which the highest transformation efficiency was generated. The endogenous promoter pPyACT1 could control gene expression efficiently compared to pPyUBC, pPyDPE2, and pPyEF1-a, especially the exogenous promoter d35S. Finally, the foreign genes PyGUS and PyHygR were stably expressed in different generations of transformants, including monospores, gametophytes, and filamentous sporophytes. Southern blotting analysis confirmed that PyGUS was integrated into the genome of N. yezoensis transformants. Establishing an efficient gene expression toolbox provides a strong foundation for functional genomics research and molecular genetic breeding on N. yezoensis.
AgNP-AC Composite Fibers and its Adsorption and Antibacterial Properties
Authors: Liu Dandan , Zhang Chuanwei , Wang Bin , Quan Wenwen , Xu Chao 
Published: May 2022

In this study, the electrospinning method was used to prepare silver nanoparticle–activated carbon (AgNP-AC) composite nanofiber membranes, aiming to obtain a high-performance dual-functional filter composite fiber membrane with good antibacterial and adsorption properties. A scanning electron microscope (SEM), X-ray diffractometer (XRD), and other instruments were used to characterize the morphology and structure of the composite nanofibers. The effects of different concentrations of activated carbon, silver, and polymer (polyethylene–vinyl alcohol—EVOH) on the fiber morphology were discussed. The adsorption performance and antibacterial performance of the composite fiber membrane were investigated to verify the mutual influence of silver and activated carbon. The results show that with the increase in the activated carbon and silver concentration, the fiber diameter of the AgNP-AC membrane increase and the diameter distribution tends to become uniform. When the mass fraction of polymer EVOH is 10% and the concentration ratio of silver nitrate and carbon is 0.05 and 0.085 (g/ml), the adsorption performance of the composite fiber membrane is at the best with an adsorption rate of 94.07%. The AgNP-AC composite nanofiber membrane also demonstrates a good antibacterial function against Staphylococcus aureus and is most effective in the first 8 h. However, it is found that the silver concentration is proportional to the antibacterial ability, but the activated carbon has a certain inhibitory effect on the antibacterial properties.
Clinical Relevance of the LVEDD and LVESD Trajectories in HF Patients With LVEF < 35%
Authors: Chen Yu-Chen , Hsing Shi-Chue , Chao Yuan-Ping , Cheng Yung-Wen , Lin Chin-Sheng , Lin Chin , Fang Wen-Hui 
Published: May 2022

BackgroundCertain variables reportedly are associated with a change in left ventricular ejection fraction (LVEF) in heart failure (HF) with reduced ejection fraction (HFrEF). However, literature describing the association between the recovery potential of LVEF and parameters of ventricular remodeling in echocardiography remains sparse.MethodsWe recruited 2,148 HF patients with LVEF &lt; 35%. All patients underwent at least two echocardiographic images. The study aimed to compare LVEF alterations and their association with patient characteristics and echocardiographic findings.ResultsPatients with “recovery” of LVEF (follow-up LVEF ≥ 50%) were less likely to have prior myocardial infarction (MI), had a higher prevalence of atrial fibrillation (Af), were less likely to have diabetes and hypertension, and had a smaller left atrium (LA) diameter, left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD), both in crude and in adjusted models (adjustment for age and sex). LVEDD cutoff values of 59.5 mm in men and 52.5 mm in women and LVESD cutoff values of 48.5 mm in men and 46.5 mm in women showed a year-to-year increase in the rate of recovery (follow-up LVEF ≥ 50%)/improvement (follow-up LVEF ≥ 35%), p-value &lt; 0.05 in Kaplan–Meier estimates of the cumulative hazard curves.ConclusionsOur study shows that LVEDD and LVESD increments in echocardiography can be predictors of changes in LVEF in in HF patients with LVEF &lt; 35%. They may be used to identify patients who require more aggressive therapeutic interventions.