bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidental Zenker’s diverticulum during exploration of penetrating neck wound
Authors: Nyren Molly Q , Rosenthal Martin D 
Published: April 2022

Abstract
Intraoperative incidental findings are a persistent concern for surgeons. Even when such findings are not overtly life-threatening, surgeons must quickly decide whether to intervene. Esophageal diverticula are rare and underdescribed incidental findings associated with increased morbidity. A 40-year-old man was brought in by EMS after sustaining a penetrating Zone II left anterolateral neck wound. Emergent surgical exploration revealed a full-thickness distal oropharyngeal injury. The endotracheal tube was exposed and a Zenker’s diverticulum was identified on the superior edge of the laceration. The diverticulum was excised and oversewn along with the oropharyngeal laceration repair. Intraoperative esophagogastroduodenoscopy leak test and 7-day post-op computed tomography esophagram were negative. Our case describes the first successful management of an incidental Zenker’s diverticulum in the literature. The decision to resect the diverticulum allowed for proper repair of the oropharyngeal laceration and improved outcomes by reducing the need for future surgical intervention.
Review Essay: Implicated in violence: Socio-legal approaches to international humanitarian law and international criminal law
Authors: Wilke Christiane 
Published: April 2022

Abstract
Kamari Maxine Clarke, Affective Justice: The International Criminal Court and the Pan-Africanist Pushback (Duke University Press 2020).
Noura Erakat, Justice for Some: Law and the Question of Palestine (Stanford University Press 2019).
Neve Gordon and Nicola Perugini, Human Shields: A History of People in the Line of Fire (University of California Press 2020).
Craig Jones, The War Lawyers: The United States, Israel, and Juridical Warfare (Oxford University Press 2020).
Rebecca Sutton, The Humanitarian Civilian: How the Idea of Distinction Circulates Within and Beyond International Humanitarian Law (Oxford University Press 2021).
Core-collapse, evaporation, and tidal effects: the life story of a self-interacting dark matter subhalo
Authors: Zeng Zhichao Carton , Peter Annika H G , Du Xiaolong , Benson Andrew , Kim Stacy , Jiang Fangzhou , Cyr-Racine Francis-Yan , Vogelsberger Mark 
Published: April 2022

ABSTRACT
Self-interacting dark matter (SIDM) cosmologies admit an enormous diversity of dark matter (DM) halo density profiles, from low-density cores to high-density core-collapsed cusps. The possibility of the growth of high central density in low-mass haloes, accelerated if haloes are subhaloes of larger systems, has intriguing consequences for small-halo searches with substructure lensing. However, following the evolution of ${\lesssim}10^8 \, \mathrm{M}_\odot$ subhaloes in lens-mass systems (${\sim}10^{13}\, \mathrm{M}_\odot$) is computationally expensive with traditional N-body simulations. In this work, we develop a new hybrid semi-analytical + N-body method to study the evolution of SIDM subhaloes with high fidelity, from core formation to core-collapse, in staged simulations. Our method works best for small subhaloes (≲1/1000 host mass), for which the error caused by dynamical friction is minimal. We are able to capture the evaporation of subhalo particles by interactions with host halo particles, an effect that has not yet been fully explored in the context of subhalo core-collapse. We find three main processes drive subhalo evolution: subhalo internal heat outflow, host-subhalo evaporation, and tidal effects. The subhalo central density grows only when the heat outflow outweighs the energy gain from evaporation and tidal heating. Thus, evaporation delays or even disrupts subhalo core-collapse. We map out the parameter space for subhaloes to core-collapse, finding that it is nearly impossible to drive core-collapse in subhaloes in SIDM models with constant cross-sections. Any discovery of ultracompact dark substructures with future substructure lensing observations favours additional degrees of freedom, such as velocity-dependence, in the cross-section.
Selumetinib in children with neurofibromatosis type 1 and asymptomatic inoperable plexiform neurofibroma at risk for developing tumor-related morbidity
Authors: Gross Andrea M , Glassberg Brittany , Wolters Pamela L , Dombi Eva , Baldwin Andrea , Fisher Michael J , Kim AeRang , Bornhorst Miriam , Weiss Brian D , Blakeley Jaishri O , Whitcomb Patricia , Paul Scott M , Steinberg Seth M , Venzon David J , Martin Staci , Carbonell Amanda , Heisey Kara , Therrien Janet , Kapustina Oxana , Dufek Anne , Derdak Joanne , Smith Malcolm A , Widemann Brigitte C 
Published: April 2022

Abstract

Background
Selumetinib was recently approved for the treatment of inoperable symptomatic plexiform neurofibromas (PNs) in children with neurofibromatosis type 1 (NF1). This parallel phase II study determined the response rate to selumetinib in children with NF1 PN without clinically significant morbidity.

Methods
Children with NF1 and inoperable PNs, which were not yet causing clinically significant morbidity but had the potential to cause symptoms, received selumetinib at 25 mg/m2 orally twice daily (1 cycle = 28 days). Volumetric magnetic resonance imaging analysis and outcome assessments, including patient-reported (PRO), observer-reported, and functional outcome measures were performed every 4 cycles for 2 years, with changes assessed over time. A confirmed partial response (cPR) was defined as PN volume decrease of ≥20% on at least 2 consecutive scans ≥3 months apart.

Results
72% of subjects experienced a cPR on selumetinib. Participants received selumetinib for a median of 41 cycles (min 2, max 67) at data cutoff. Approximately half of the children rated having some target tumor pain at baseline, which significantly decreased by pre-cycle 13. Most objectively measured baseline functions, including visual, motor, bowel/bladder, or airway function were within normal limits and did not clinically or statistically worsen during treatment.

Conclusions
Selumetinib resulted in PN shrinkage in most subjects with NF1 PN without clinically significant morbidity. No new PN-related symptoms developed while on selumetinib, and PRO measures indicated declines in tumor-related pain intensity. This supports that selumetinib treatment may prevent the development of PN-related morbidities, though future prospective studies are needed to confirm these results.

Clinical Trial registration
ClinicalTrials.gov NCT01362803.
Association between area-level material deprivation and incidence of hospitalization among children with SARS-CoV-2 in Montreal
Authors: Abda Assil , del Giorgio Francesca , Gauvin Lise , Autmizguine Julie , Kakkar Fatima , Drouin Olivier 
Published: April 2022

Abstract

Background
Although sociodemographic factors have been linked with SARS-CoV-2 infection and hospitalizations in adults, there are little data on the association between sociodemographic characteristics and SARS-CoV-2-related hospitalization in children. The objective of this study was to determine the association between area-level material deprivation and incidence of hospitalization with SARS-CoV-2 among children.

Methods
We conducted a retrospective cohort study of all children (0 to 17 years of age) with a PCR-confirmed SARS-CoV-2 infection March 1, 2020 through May 31, 2021 at a tertiary-care paediatric hospital, in Montreal, Canada. Data were collected through chart review and included age, sex, and postal code, allowing linkage to dissemination area-level material deprivation, measured with the Pampalon Material Deprivation Index (PMDI) quintiles. We examined the association between PMDI quintiles and hospitalization using Poisson regression.

Results
During the study period, 964 children had a positive PCR-confirmed SARS-CoV-2 test and 124 were hospitalized. Children living in the most deprived quintile of PMDI represented 40.7% of hospitalizations. Incidence rate ratio of hospitalization for this group compared to the most privileged quintile was 2.42 (95%CI: 1.33; 4.41).

Conclusion
Children living in the most materially deprived areas had more than twice the rate of hospitalizations for COVID-19 than children living in most privileged areas. Special efforts should be deployed to protect children who live in disadvantaged areas, especially pending vaccination of younger children.
Light-induced displacement of PLASTID MOVEMENT IMPAIRED1 precedes light-dependent chloroplast movements
Authors: Dwyer Matthew E , Hangarter Roger P 
Published: April 2022

Abstract
Light-dependent chloroplast movements are an actin-dependent cellular response to changes in the light environment that help plants maximize photosynthetic potential and reduce photodamage. Over a dozen proteins are known to be required for normal chloroplast movements, but the molecular mechanisms regulating the transformation of light perception into chloroplast motility are not fully understood. Here, we show that in Arabidopsis (Arabidopsis thaliana) the actin-bundling plasma membrane-associated proteins THRUMIN1, PLASTID MOVEMENT IMPAIRED1 (PMI1), and KINESIN-LIKE PROTEIN FOR ACTIN-BASED CHLOROPLAST MOVEMENT1 (KAC1) interact through the 14-3-3 proteins KAPPA and OMEGA. We also show that the interaction of PMI1 with 14-3-3 KAPPA and OMEGA is regulated by blue light activation of the Phototropin2 photoreceptor. Live-cell confocal microscopy revealed light-induced dynamic changes in the cellular localizations of PMI1 and KAC1. In particular, PMI1 was relocated away from irradiated areas of the plasma membrane in less than a minute after blue light exposure, consistent with PMI1 playing a critical role in initiating light-dependent chloroplast movements. We present a modified conceptual model for high light-dependent chloroplast movements in which PMI1 acts as the mobile signal that initiates a coordinated sequence of changes in protein–protein and protein–plasma membrane interactions that initiate the chloroplast movement response and determine where in the cell chloroplasts are able to anchor to the plasma membrane.
A Bayesian zero-one inflated beta modeling of dairy farmers’ decision to sell nothing or some output through contract farming
Authors: Ng'ombe John N , Kabwela Benny , Kiwanuka-Lubinda Rebecca N , Addai Kwabena Nyarko 
Published: April 2022

AbstractSmallholder farmers’ preferences for participation in contract farming may take the form of proportional data––whereby farmers only sell some proportions or fractions of their output to contractors. We analyze determinants for preferences for zero (potential corner solution) and proportional amounts of milk that farmers sell through contract farming, using dairy farmers’ data from Zambia. Bayesian linear, linear probability, and hurdle models are compared with a Bayesian zero-one inflated beta regression. Monte Carlo simulations show that alternative models are biased. Meanwhile, empirical findings suggest that gender and marital status of the household head, household size, and delayed payment significantly drive preferences for proportional milk sales in contract farming. Additionally, household size, experience selling through milk collection centers, total livestock units, access to dairy marketing information, and a buyer's milk price, among others, tend to affect zero-inflated outcomes. We recommend a Bayesian zero-one inflated beta regression model for proportional data and also provide strategies to overcome farmer-engagement barriers in contract farming.
Early onset is an indication of the severity of DADA2 disease
Authors: Zhao Xiaozhen , Zhang Junmei , Li Caifeng , Kuang Weiying , Deng Jianghong , Tan Xiaohua , Li Chao , Li Shipeng , Wang Jiang 
Published: April 2022

Abstract

Objective
To find indicators of disease severity and factors of early remission in patients with deficiency of adenosine deaminase 2 (DADA2).

Methods
We enrolled six DADA2 patients from six families. Direct sequencing of adenosine deaminase 2 gene (ADA2) was performed by Sanger analysis. A literature review was conducted for articles regarding paediatric DADA2.

Results
We found that more organs were involved in early-onset (≤1 year of age) than in late-onset (&gt;1 year of age) DADA2 patients had high level inflammatory responses, such as elevated ESR, SF, serum amyloid A and CRP. Disease severity was not significantly different from missense and frameshift mutation. Early administration of TNF inhibitor might result in better remission and reduce recurrence. In the literature, four articles describing 51 paediatric DADA2 patients were identified. We also found that fever, stroke, peripheral nervous system involvement, hypogammaglobulinaemia and hypertension were more frequent in early onset DADA2 patients.

Conclusion
Early-onset DADA2 may be more severe. Early administration of TNF inhibitor can effectively reduce recurrence and quickly alleviate the disease.
Extent of vascular plaque predicts future cardiovascular events in patients with systemic lupus erythematosus
Authors: Bakshi Jyoti , Croca Sara C , Griffin Maura , Farinha Filipa , Isenberg David A , Nicolaides Andrew , Rahman Anisur 
Published: April 2022

Abstract

Objective
Patients with SLE have increased prevalence of clinical cardiovascular disease (CVD) and subclinical atherosclerosis. Although 30–40% of patients with SLE have vascular plaque on ultrasound scanning, this study is the first to consider the relationship between total burden of plaque and subsequent CVD risk.

Methods
One hundred patients with SLE and without any previous clinical CVD underwent vascular ultrasound scans of both carotid and both common femoral bifurcations between 2011 and 2013. Clinical, serological, demographic and treatment data were collected at baseline. Patients were followed till 2020 to identify those who developed new onset coronary disease or stroke. Statistical analysis to identify factors associated with increased risk of developing CVD events was carried out.

Results
Thirty-six patients had plaque at baseline. During follow-up five patients (all had baseline plaque) developed coronary disease and two, without baseline plaque, developed lacunar strokes. Mean (s.d.) age of these patients was 46.5 (4.5) years. Patients with three or more baseline bifurcations with plaque were 10 times more likely to develop CVD than those with 0–2 bifurcations with plaques (OR 9.9, P = 0.009). TPA &gt; 16mm2 was associated with six-fold increased risk of CVD (OR = 6.44, P = 0.028). Patients with disease duration &gt; 14 years were more likely than those with disease duration &lt; 14 years to develop CVD (OR 8.3 P = 0.043)

Conclusions
The number of bifurcations with plaque and TPA in patients with SLE may be valuable in assessing risk of CVD and deciding on clinical measures to reduce this risk.
Development and validation of the multicopter modelling code: a physics-based tool for multicopter analysis
Authors: Oppong David Kofi , Obu Evans , Asare Timothy , Aidam God'sable Sitsofe Koku 
Published: April 2022

Purpose
This study aims to present details of the development and validation of the multicopter modelling code (MMC), a tool for the analysis of small-scale multicopters based on flight physics.

Design/methodology/approach
The development effort involved the study of aircraft dynamics and translating the equations of motion into MATLAB code. The authors also developed several auxiliary functions, so that the tool could trim the aircraft about a steady state, linearize the dynamic equations to produce a model that could be used for control systems design and carry out flight simulation.

Findings
MMC proved to be of good accuracy, producing results similar to those of other software such as AcuSolve, Overflow and the Rensselaer Multicopter Analysis Code (RMAC), which served as the motivation for this study.

Originality/value
The tool presented here provides an alternative to the aforementioned software, which are not freely available, programmed in MATLAB, a language well known to engineers and scientists.
“Same, same but different”: insights on ageing consumers and their expectations of institutional food
Authors: Andreassen Hanne , Gjerald Olga , MyrnesHansen Kai Victor 
Published: April 2022

PurposeSocieties are experiencing a rapidly ageing population, which puts pressure on health services and institutions for the elderly. Ageing baby boomers have unique characteristics compared to previous generations, yet very little is known about these consumers' expectations of institutional food. The importance and issues with institutional food are well-recognized, and new approaches to improving institutional food offerings are warranted. The purpose of this study was to identify various segments of ageing consumers based on individual characteristics (entitlement, subjective food knowledge, disconfirmation sensitivity and age) and investigate differences in expectations between the groups.Design/methodology/approachData were collected using a cross-sectional survey (n = 300) of ageing consumers (50–80 years old). A two-step cluster analysis was used to identify meaningful clusters.FindingsA four-cluster solution was reached, with clusters (1) “Uninvolved oldies”, (2) “Humble old foodies”, (3) “Entitled youngsters” and (4) “Food experts”. This study found significant differences in expectations of institutional food between the clusters.Practical implicationsRecommendations for public policy implications for each segment are provided. This study contributes to preparing healthcare services and institutions to meet the institutional food expectations of various types of ageing consumers.Originality/valueThis paper measures ageing consumers' normative expectations of institutional food and concludes that expectations of food quality, freedom of choice, servicescape and sustainability differ by segments of ageing consumers.
Know your guests’ preferences before they arrive at your hotel: evidence from TripAdvisor
Authors: Rahimi Roya , Thelwall Mike , Okumus Fevzi , Bilgihan Anil 
Published: April 2022

PurposeToward achieving a better guest experience, the current study aims to use the word frequency comparison technique to evaluate the types of attributes and services that are used most frequently in guests’ five- and one-star reviews on TripAdvisor. The working-paper also aims to investigate the differences between reviews written by men and women.Design/methodology/approachA combined sentiment and text analysis was applied to 329,849 UK hotel reviews from UK TripAdvisor to identify factors that influence customer satisfaction, including those with gender differences.FindingsThe present findings reveal important differences between the male- and female-produced terms. The results show that female travelers pay more attention to the hotel’s core products and their comfort compared to male travelers. In terms of food and beverage, men’s comments tended to focus on pubs, beer and certain types of food. In contrast, women’s comments were more likely to be related to healthy eating, such as homemade, vegan and vegetarian foods, as well as fruits and healthy breakfasts. Women also pay more attention to the soft skills of staff such as friendliness, helpfulness and welcoming messages.Practical implicationsWhile core attributes of a hotel stay remain crucial for all guests, disparities exist between the language men and women use to describe them. For core products, women pay more attention to the room’s cleanliness, comfort and features such as bed, pillow, blanket, towel, toiletries and decoration, whereas men pay more attention to the layout, size and type of room. Hotels may use gender as a segmentation variable and use these findings in their marketing campaigns.Originality/valueThis is one of the first studies offering insights into the differences between the male and female reactions to and preferences for hotel services at a national level. Following a novel method, this study has listed and ranked attributes and differentiated them based on gender.
The impact of project manager’s emotional intelligence on project performance: a meta-analysis
Authors: Zhang Qi , Hao Shengyue , Chung Kon Shing Kenneth 
Published: April 2022

PurposeA project manager’s (PM) emotional intelligence (EI) is essential for project performance (PP). However, the cause and effect and the potential moderators of the relationship between EI and PP remain disputed. Some scholars found a positive association between PMs’ EI and project outcomes, while some other studies showed non or negative relation. This paper aims to find the relationship between PMs’ EI and PP and the factors that influence this relationship based on diverse prior research.Design/methodology/approachThis paper conducts a meta-analysis of 5,229 observations based on 24 independent studies from 1990 to 2021.FindingsResults show that PMs’ EI has a significant positive influence on PP, and the project complexity and measurement of PP are two critical moderators explaining inconsistencies in existing research.Practical implicationsThe current study proposes suggestions for construction companies on PMs’ selection and training. This study also offers suggestions for PMs in management practice.Originality/valueTo the best of the authors’ knowledge, this study is the first to explore the inconsistencies in prior research results on the relationship between PMs’ EI and PP at the meta-analytic level. This research extends the current literature by revealing the factors leading to existing consistencies that are not explored before. This study implies that the meta-analysis method could help reach a balanced conclusion based on inconsistent results.