bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PENAMBAHAN POTONGAN LIMBAH PLASTIK KEMASAN SUSU DENGAN BENTUK POTONGAN MEMANJANG TERHADAP BERAT JENIS, KUAT TEKAN DAN KUAT LENTUR BETON
Authors: Ernawati Sri Sunarsih Deny Priambodo, Roemintoyo, 
Published: March 2022

Pembangunan dibidang konstruksi saat ini mengalami kemajuan yang sangat pesat. Hal ini tidak lepas dari tuntutan dan kebutuhan masyarakat terrhadap infrastruktur yang semakin maju.Dalam bidang konstruksi terdapat berbagai macam material yang digunakan, salah satu material yang digunakan yaitu beton.sementara itu sisi sampah plastik kegiatan manusia jumlahnya semakin meningkat setiap tahunnya salah satunya plastik kemasan susu.Untuk dapat memanfaatkan limbah kemasan susu dan mutu beton maka diperlukan penelitian.Penelitian ini memanfaatkan limbah plastik kemasan susu guna meningkatakan karakteristik dan kualitas beton.Tujuan dari penelitian ini untuk mengetahui(1)Pengaruh variasi penambahan potongan plastik kemasan susu terhadap berat jenis beton,(2)Pengaruh variasi penambahan potongan plastik kemasan susu terhadap kuat tekan beton,(3)Pengaruh variasi penambahan potongan plastik kemasan susu terhadap kuat lentur beton,(4)Persentase optimal penambahan potongan plastik kemasan susu terhadap kuat tekan maksimal dan kuat lentur maksimal.Penelitian ini merupakan penelitian kuantitatif dengan menggunakan metode eksperimen.Perencanaan pembuatan campuran beton menggunakan metode <em>Mix Design </em>sesuai dengan SNI 03-3449-2002. Variasi persentase penambahan limbah plastik kemasan susu yang digunakan adalah 0,00%, 0,10%, 0,20%, 0,30%, 0,40%, dan 0,50% dari berat campuran beton.Dengan mutu beton yang direncanakan yaitufc’20 MPa.Karakteristik beton yang diuji dalam penelitian ini adalah berat jenis, kuat tekan, dan kuat lentur beton pada usia 28 hari.Benda uji untuk pengujian berat jenis dan kuat tekan berbentuk silinder dengan diameter 150 mm dan tinggi 300 mm.Benda uji untuk pengujian lentur berbentuk balok dengan dimensi 150 x 150 x 600 mm.Hasil pengujian (1)Beton usia 28 hari denganvariasi persentase penambahan potongan plastik kemasan susu terdapat pengaruh yang signifikan terhadap berat jenis beton.(2)Terdapat pengaruh yang signifikan pada variasi persentase penambahan potongan plastik kemasan susu terhadap kuat tekan beton.(3)Tidak terdapat pengaruh yang signifikan pada variasi persentase penambahan potongan plastik kemasan susu terhadap kuat lentur beton.(4)Persentaseoptimal penambahan potongan plastik kemasan susu terhadap kuat tekan beton maksimal yang dihasilkan yaitu berada pada persentase penambahan 0,10 % dengan kuat tekan maksimal 16,63 N/mm<sup>2</sup>. (5)Persentase optimal penambahan potongan plastik kemasan susu terhadap kuat kuat lentur maksimalbeton yang dihasilkan yaitu berada pada persentase penambahan 0,40 % dengan kuat lentir maksimal 6,19 N/mm<sup>2</sup>.
Impact on Health Care Utilization and Costs of a Medicaid Community Health Worker Program in Detroit, 2018–2020: A Randomized Program Evaluation
Authors: Heisler Michele , Lapidos Adrienne , Kieffer Edith , Henderson James , Guzman Rebeca , Cunmulaj Jasmina , Wolfe Jason , Meyer Trish , Ayanian John Z. 
Published: March 2022

Objectives. To compare health care utilization and costs between beneficiaries randomly assigned to usual services versus a community health worker (CHW) program implemented by 3 Medicaid health plans. Methods. From February 2018 to June 2019, beneficiaries residing in Detroit, Michigan’s Cody Rouge neighborhood with more than 3 emergency department (ED) visits or at least 1 ambulatory care‒sensitive hospitalization in the previous 12 months were randomized. CHWs reached out to eligible beneficiaries to assess their needs and link them to services. We compared ED and ambulatory care visits, hospitalizations, and related costs over 12 months. Results. In intention-to-treat analyses among 2457 beneficiaries, the 1389 randomized to the CHW program had lower adjusted ratios of ED visits (adjusted rate ratio [ARR] = 0.96; P < .01) and ED visit costs (ARR = 0.96; P < .01), but higher adjusted ratios of ambulatory care costs (ARR = 1.15; P < .01) and no differences in inpatient or total costs compared with the usual-care group. Conclusions. Initial increases in ambulatory care use from effective programs for underserved communities may mitigate savings from decreased acute care use. Longer-term outcomes should be followed to assess potential cost savings from improved health. Trial Registration: ClinicalTrials.gov identifier: NCT03924713. (Am J Public Health. 2022;112(5):766–775. https://doi.org/10.2105/AJPH.2021.306700 )
Prevalence of Alzheimer’s and Related Dementia Diseases and Risk Factors Among Transgender Adults, Florida, 2012‒2020
Authors: Guo Yi , Li Qian , Yang Xi , Jaffee Michael S. , Wu Yonghui , Wang Fei , Bian Jiang 
Published: March 2022

Objectives. To estimate the prevalence rates of Alzheimer’s disease and related dementias (ADRD) and their risk factors in the transgender population and compare the rates to those in cisgender adults. Methods. We identified 1784 transgender adults in the linked electronic health records and claims data between 2012 and 2020 from the OneFlorida Clinical Research Consortium. We calculated the prevalence of ADRD and ADRD risk factors for the transgender and matched cisgender control adults. Results. The prevalence of ADRD was higher in the transgender adults compared with the cisgender control adults. Overall, the prevalence of ADRD risk factors was significantly higher in the transgender adults than the cisgender controls for 11 out of the 13 risk factors, with the only exceptions being traumatic brain injury and visual impairment. Conclusions. Transgender adults are at significantly higher risk for ADRD than cisgender adults. Our study highlights the urgent need for more research on the unique ADRD risks among the aging transgender and larger sexual- and gender-minority populations. (Am J Public Health. 2022;112(5):754–757. https://doi.org/10.2105/AJPH.2022.306720 )
Prevalence and Sociodemographic and Behavioral Correlates of Psychological Distress among Lesbian, Gay, and Bisexual Adults in the United States, 2013-2018
Authors: Singh Gopal K , Lee Hyunjung , Daus Gem P. 
Published: March 2022

Background: The lesbian, gay, bisexual, and transgender (LGBT) population comprises approximately 5.6% of the total US population. Levels and patterns of psychological distress in the LGBT population are less well known compared with the general population. This study examines the prevalence and sociodemographic and behavioral correlates of psychological distress among lesbian, gay, and bisexual (LGB) adults in the United States.
Methods: Using the pooled cross-sectional data from the 2013-2018 National Health Interview Surveys (N=183,020), differentials in serious psychological distress (SPD) and factor-based psychological distress scores were analyzed by multivariate linear and logistic regression.
Results: The prevalence of SPD was 8.0% for the LGB population aged ≥18, 7.0% for gay and bisexual males, and 8.9% for LGB females, compared with 3.4% for the total straight/heterosexual population, 2.7% for straight males, and 4.0% for straight females. Mean psychological distress index scores were highest among LGB females (109.8), followed by gay and bisexual males (105.8), straight females (100.6), and straight males (97.7). Compared with the straight population, LGB adults had higher education, unemployment, and poverty levels and were more likely to be non-Hispanic White and single. LGB adults were more likely to smoke and drink alcohol and more likely to be physically active than straight adults. LGB females had higher obesity but gay and bisexual males had lower obesity rates than their straight counterparts. After controlling for covariates, LGB adults had 89% higher odds of SPD and significantly higher distress levels than straight adults. Younger age, lower-income, divorce/separation, lack of health insurance, functional limitation, smoking, physical inactivity, and obesity were significant predictors of SPD and higher psychological distress levels in LGB adults.
Conclusion and Implications for Translation: Significant disparities in mental health exist, with LGB adults at substantially increased risk of psychological distress and likely in greater need of appropriate social and mental health services. Health policies aimed at improving the material conditions and social environments may lead to improved mental health outcomes among LGB adults and the general population.

Copyright © 2022 Singh, et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
Eficiência nos atendimentos hospitalares nas capitais brasileiras no período de 2014-2017
Authors: Cavalcanti Ivanessa , Amorim Inara , Fraga Joana , Ferreira Júnior Hamilton 
Published: March 2022

Objetivo: Analisar o nível de eficiência dos atendimentos hospitalares nas capitais estaduais e Distrito Federal entre os anos de 2014 a 2017. Métodos: O método de investigação utilizado foi a Análise Envoltória de Dados para estimar os níveis de eficiência dos recursos. Resultados: Os resultados indicam que ocorrem diferenças no nível de eficiência das capitais estaduais e Distrito Federal, sendo possível desenvolver o potencial das unidades ineficientes, de forma que aumentem a eficiência técnica nos atendimentos hospitalares. Conclusão: Analisar o uso dos recursos públicos contribui para identificar se os recursos estão sendo aplicados de forma eficiente e, quando não, sinaliza para a necessidade de tomada de decisões mais coerentes com a realidade de cada capital.
A dual-activity topoisomerase complex regulates translation and abundance of mRNAs important for psychiatric disorders
Authors: Su Shuaikun , Xue Yutong , Sharov Alexei , Zhang Yongqing , Lee Seung kyu , Martindale Jennifer , Li Wen , Ku Wai Lim , Zhao Keji , De Supriyo , Sen Payel , Gorospe Myriam , Xu Dongyi , Wang Weidong 
Published: March 2022

Abstract
Topoisomerase 3b (TOP3B)-TDRD3 is a dual-activity topoisomerase complex in animals that can change topology for both DNA and RNA. A current hypothesis proposes that this complex interacts with Fragile X mental retardation protein, FMRP, to regulate mRNA translation. Here we examined this hypothesis by identifying TOP3B-TDRD3-bound mRNAs in human HCT116 cells; and analyzing the effect of inactivating TOP3B, TOP3B catalytic activity, TDRD3, and FMRP, on translation and abundance of these mRNAs. We found that TOP3B-TDRD3 resembles FMRP in preferentially binding to coding regions of long mRNAs. Complete inactivation of TOP3B protein, but not a point mutation that only disrupts TOP3B catalytic activity, preferentially reduced the abundance of the TOP3B-TDRD3-bound mRNAs. Moreover, ablation of the complex or inactivation of TOP3B catalytic activity alters translation for some but not all TOP3B-TDRD3 bound mRNAs, suggesting that TOP3B-TDRD3 may solve topological problems for specific mRNAs. Finally, several schizophrenia and autism-risk genes are bound and regulated by TOP3B-TDRD3 in mRNA translation and abundance by topoisomerase activity dependent and independent manners. Our data suggest that TOP3B-TDRD3 can regulate mRNA translation and abundance by topoisomerase activity dependent or independent mechanisms; and disruption of this function could contribute to pathogenesis of psychiatric disorders in TOP3B mutation carriers.
Mid-pregnancy poly(I:C) viral mimic disrupts placental ABC transporter expression and leads to long-term offspring motor and cognitive dysfunction
Authors: Ortiga-Carvalho Tania Maria , Monteiro Victoria Regina de S. , Andrade Cherley B. V. , Gomes Hanailly R. , Reginatto Mila W. , Império Güínever E. , Fontes Klaus N. , Spiess Daiane A. , Junior William S. R. , Nascimento Veronica M. O. , Lima Camila O. S. , Sousa Ronny P. C. , Bloise Flavia F. , Matthews Stephen G. , Bloise Enrrico , Pimentel-Coelho Pedro M. 
Published: March 2022

Abstract
Limited information is available about the effect of mid-pregnancy viral infections on the placental expression of efflux transporters and offspring behavior. We hypothesized that maternal exposure to polyinosinic-polycytidylic acid [poly(I:C)], a synthetic double-stranded RNA viral mimic, would impair placental cell turnover, the expression of selected ABC transporters and adult offspring behavior. C57BL/6 mice were administered poly(I:C) (10mg/Kg;ip) or vehicle at gestational day (GD) 13.5 (mid-pregnancy). Dams were euthanized for blood collection 4 h after injection, fetal and placental collection at GD18.5 or allowed to deliver spontaneously at term. At GD 13.5, poly(I:C) induced an acute pro-inflammatory response characterized by an increase in maternal plasma levels of IL-6, CXCL-1 and CCL-2. At GD 18.5, poly(I:C) decreased cell proliferation/death in the labyrinthine and increased cell death in the junctional zones, a disruption of placental cell turnover. Abca1 and Abcg1 immunolabelling was decreased in the labyrinthine zone, but Abca1, Abcg1 and breast cancer resistance transporter (Bcrp) expression increased in the junctional zone. Moreover, adult offspring showed motor and cognitive impairments in the Rotarod and T-water maze tests. These results indicate that viral infection during mid-pregnancy may disrupt the placental barrier and offspring behavior in adult life.
The effect of water shower spray on stress physiology and mortality in broiler chickens subjected to road transportation under the hot and humid tropical condition
Authors: Abidin Zulaikha Zainool , Sulaiman Nur Farrah Aizurin , Ramiah Suriya Kumari , Awad Elmutaz Atta , Idrus Zulkifli 
Published: March 2022

Abstract
This study was performed to investigate the effect of water shower spray on rectal temperature (RT), serum levels of corticosterone (CORT), heat shock protein (HSP) 70 and creatine kinase (CK) in broiler chickens road transported at different times of the day. A total of 320 male broiler chickens (35 days of age) were crated and subjected to either water shower spray (WS) for 10 minutes or no water shower (control). The WS and control broilers were then loaded into an open truck and transported either from 0900 h to 1100 h (29.0oC and 89.0% RH) (AM) or 1900 h to 2100 h (26.0oC and 94.0% RH) (PM) with an average speed of 80 km/h. The CORT of AM birds were significantly reduced by WS, but the treatment had negligible influence on the PM group. Transportation during AM significantly elevated RT, CORT and HSP70 compared to the PM group. Water shower spraying of birds before transit significantly reduced RT and HSP70 compared to controls. Neither water shower treatment nor transportation time had a significant on CK and mortality rate of broilers. In conclusion, water shower spray is beneficial to alleviate the physiological stress response in road transported broilers under the hot and humid tropical environment.
Perpetuation of Gender Discrimination in Pakistani Society: Results from a Qualitative Study Conducted in Three Provinces of Pakistan
Authors: Ali Tazeen Saeed , Ali Shahnaz Shahid , Nadeem Sanober , Memon Zahid , Soofi Sajid , Madhani Falak , Karim Yasmin , Mohammad Shah , Bhutta Zulfiqar 
Published: March 2022

Abstract
BackgroundPrejudice based on one’s gender leads to contempt, mistreatment, and marginalization, which can be characterized as gender discrimination. This occurrence appears in every country of the world and in many societies in which women are often on the receiving end. It affects the provision of women’s rights and negatively impacts their physical and emotional livelihoods. Thus, this study aims to qualitatively evaluate the reasons for gender discrimination in a specific country, Pakistan, and how women are affected. MethodsParticipant recruitment was done with purposive sampling. The collection of the data included community leaders/workers and various families using in-depth interviews and focused group discussions. The subsequent data analysis was manually done and electronically through QSR NVivo 10. All data were then complied with and verified by the research team. ResultsThe focus of the collected data resulted in three emergent themes. Firstly, gender discrimination seems to be geared more towards women based on how they are perceived by the community. Specifically, women are viewed as sexual objects and dependent beings, who are not identifiable as an individual unless they have a male partner. They are also subject to restrictive responsibilities, inherent to the household, while being deprived of rights, being neglected, and forced to suppress self-expression. Secondly, men are viewed as dominant figures in the lives of women, who often make all the familial decisions and do not share issues with their wives. This puts them in the role to be the financial provider and a source of protection, hence, the desire for male children to be born over female children. Thirdly, many institutions are involved in perpetuating gender discrimination including older generations, media, schools, and healthcare. Participants also gave recommendations to tackle the issue at hand including increasing education and healthcare resources. DiscussionThis study highlights the perpetuation of gender norms as a result of perceptions and cultural norms held by Pakistani society. To promote the wellbeing and rights of women more action is needed. Social movements, drawn out from social institutions, have proven useful for women's empowerment and advocation of societal change. Conclusion Due to the largely patriarchal society, Pakistani society continues to encourage gender discrimination through complex gender roles, with high resistance to change. Yet, this can be slowly altered as education can grow for men and women, thus, leading to a public effort with the power to improve the provision of rights for women in Pakistan
Efficacy and Pharmacokinetic of Human iPSC-derived Cardiomyocytes for Treating Heart Failure in Non-Human Primates
Authors: Liang Ningxia , Wang Qian , Zhang He , Li Zhaomin , Chen Taotao , Xu Faxiang , Guo Zhixin , Chen Guokai , Yang Huang-Tian , Wang Dongjin , Wang Guangji , Wang Jiaxian 
Published: March 2022

Abstract
Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (HiCM) transplantation is a potential next generation cell therapy to repair the injured myocardium. However, a systemic study is yet to be conducted to evaluate the efficacy, distribution, and safety of HiCM transplantation. Here using a Rhesus monkey model of myocardial infarction, we studied the efficacy of HiCM in repairing cardiac function and found HiCM significantly restored the ejection fraction (EF%) and fractional shortening (FS%) at 4 weeks after transplantation and the benefit lasted through 12 weeks. Furthermore, by using PET/CT tracking, we first demonstrated real-time biodistribution of radiolabeled hiPSC-CMs (89Zr-HiCM) in non-human primates, and found the majority of transplanted HiCM cells retained in heart after 504 hours. No tumor or ventricular arrhythmia was detected up to 32 weeks of observation. These results provide strong evidence to support HiCM as a potential reparative cure for cardiac damage.
Determination of Natural Distribution Areas and Some Agro-Morphological Characteristics with Sexual Dimorphism of Wild Asparagus (Asparagus Officinalis L.) in Iğdır Plain-Turkey
Authors: Özden Eren , Şeyran Ahmet , Koçak Mehmet Zeki , Kumlay Ahmet Metin , Tel Ahmet Zafer , Alma Mehmet Hakkı 
Published: March 2022

Abstract
Globally, interest in wild plants has been on the rise in recent years. The potential of wild plants to be used in breeding for sustainable agriculture and people's preference for consumption attract research attentions. The study was aimed to investigate the natural distribution of Asparagus officinalis L. taxon, along the Iğdır plain, one of the largest micro-climate regions of Turkey and consumed by the people of the region. The research was also motivated to evaluate wild Asparagus species using some agro-morphological characteristics with sexual dimorphism, for a two years study period. It has been identified that asparagus spreads along the Aras river forming the border of Armenia at altitudes of 800–1076 masl in the region and most densely populated in Karakoyunlu district. The result of the present investigation revealed a wide range of variations for agro-morphological characteristics like days to fruit ripening (76–91 d), edible spear length (168.21-315.34 mm), diameter (6.30-10.86 mm), fresh weight (5.27–19.52 g), dry weight (0.38–1.55 g), number of spear (8–26 plant-1), number of fruit (61-2467 spear-1), fruit weight (8.0-258.3 g spear-1), male plant length (1116.9-2.163.7 mm), female plant length (1219.4-2110.2 mm), male pedicle length (3.72–4.17 mm) and female pedicle length (3.21–3.54 mm) were observed, which can be useful for breeding purposes. Cluster constellation analysis was conducted to investigate the genetic diversity of 31 asparagus genotypes. According to the agro-morphological properties, asparagus were divided into 2 main groups and 4 sub-groups (A; A1, A2 and B; B1, B2). Aralık district samples were mostly collected in the B1 (pink), Karakoyunlu district in the B2 (blue), Tuzluca district in the Al (red) and A2 (green), and Iğdır district mostly in the B2 (blue) cluster. As a result, Karakoyunlu were found superior with the highest asparagus density and edible spear yield as compared to other districts. In order protect the habitat of wild asparagus from excessive consumption and losses due to climate changes, seeds should be collected from these areas to be used for cultivation and breeding purposes. In addition, it is advisable to keep seeds in gene banks for sustainable agriculture and protection of genetic diversity.
Determining Factors Associated with Cholera Disease in Ethiopia using Bayesian Hierarchical Modeling
Authors: Letta Tsigereda Tilahun , Belay Denekew Bitew , Ali Endale Alemayehu 
Published: March 2022

Abstract
Background: Cholera is a diarrheal disease caused by infection of the intestine with the gram-negative bacteria Vibrio cholera. It is caused by the ingestion of food or water and infected all age groups. This study aimed at identifying risk factors associated with cholera disease in Ethiopia using the Bayesian hierarchical model. Methods: The study was conducted in Ethiopia across regions and this study used secondary data obtained from the Ethiopian public health institute. Latent Gaussian models were used in this study; which is a group of models that contains most statistical models used in practice. The posterior marginal distribution of the Latent Gaussian models with different priors is determined by R-Integrated Nested Laplace Approximation. Results: There were 2790 cholera patients in Ethiopia across the regions. There were 81.61% of patients are survived from cholera outbreak disease and the rest 18.39% have died. There was 39% variation across the region in Ethiopia. Latent Gaussian models including random and fixed effects with standard priors were the best model to fit the data based on deviance. The odds of surviving from cholera outbreak disease for inpatient status are 0.609 times less than the outpatient status. Conclusions: The authors conclude that the fitted latent Gaussian models indicate the predictor variables; admission status, aged between 15 and 44, another sick person in a family, dehydration status, oral rehydration salt, intravenous, and antibiotics were significantly associated with cholera outbreak disease.