bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of Establishing a Core Set of Sexual, Reproductive, Maternal, Newborn, Child, and Adolescent Health Indicators in Humanitarian Settings: Results from a Multi-Methods Assessment in the Democratic Republic of Congo
Authors: Emina Jacques , Etinkum Rinelle , Aissaoui Anya , Gbomosa Cady Nyombe , Elamurugan Kaeshan , Lakshmi Kanya , Mowafi Ieman Mona El , Kobeissi Loulou 
Published: January 2022

Abstract
Background: Reliable and rigorously collected sexual, reproductive, maternal, newborn, child, and adolescent health (SRMNCAH) data in humanitarian settings are often sparse and variable in quality across different humanitarian settings. To address this gap in quality data, the World Health Organization (WHO) developed a core set of indicators for monitoring and evaluating SRMNCAH services and outcomes and assessed their feasibility in four countries, including the Democratic Republic of Congo (DRC) with the goal of aggregating information from global consultations and field-level assessments to reach consensus on a set of core SRMNCAH indicators among WHO partners. Methods: The feasibility assessment in DRC focused on the following constructs: relevance/usefulness, feasibility of measurement, systems and resources, and ethical issues. The multi-methods assessment included five components; a desk review, key informant interviews, focus group discussions, facility assessments, and observational sessions. Results: The findings suggest that there is widespread support among stakeholders for developing a standardized core list of SRMNCAH indicators to be collected among all humanitarian actors in DRC. There are numerous resources and data collection systems that could be leveraged, built upon, and improved to ensure the feasibility of collecting this proposed set of indicators. However, the data collection load requested from donors, the national government, international and UN agencies, coordination/cluster systems must be better harmonized, standardized, and less burdensome. Conclusions: Despite stakeholder support in developing a core set of indicators, this would only be useful if it has the buy-in from the international community. Greater harmonization and coordination, alongside increased resource allocation, would improve data collection efforts and allow stakeholders to meet indicators’ reporting requirements.
Economic Burden of Inpatient Wound Dressing in Nigeria: Implication for Catastrophic Household Expenditure
Authors: Ogundeji Kolawole Damilare , Risenga Patrone Rebecca , Thupayagale-Tshweneagae Gloria 
Published: January 2022

Abstract
Background: The literature is replete with family impoverishment resulting from out of pocket healthcare financing on the Africa continent. In Nigeria the healthcare insurance scheme is evolving and requires wider coverage. The aim of this study is to examine catastrophic household expenditure emanating from daily or alternate day wound dressing.Methods. The study was based on a descriptive cross-sectional research design to investigate the economic burden of daily or alternate day wound dressing among hospitalized patients in selected teaching hospitals in south west Nigeria. The inclusion criteria focused on inpatients about to be discharged or already spent minimum of four weeks in hospital. The data collection instrument was pre-tested with a coefficient of stability of 0.774. Respondents were selected via convenience sampling while an interview administered questionnaire was used to elicit information on wound care from patients in medical surgical wards. Covid-19 protocols were strictly adhered to and ethical approval was sought from each hospital.Results: The result revealed that the mean age of the respondents was 44.95 ± 16.12. Two-thirds were men who are artisans and traders with only secondary school education. Over 70% of the respondents have between 5 and 10 family members, more than 50% earn less than ₦50000 per month. The majority have no comorbidities (79.5%), about 50% were on daily dressing which required 1–5 moderate or major dressing packs per week. The length of hospital stay for the majority of the respondents (85.3%) was less than 11 weeks.Conclusions: The daily or alternate day wound dressing requires a financial input beyond the coping capacity of the indigenous Nigerian families. The Nigerian government should scale up coverage of health insurance scheme to cover artisans, small traders and other low income earners to reduce the incidence of catastrophic household expenditure.
Facile Fabrication of Amino-Functionalized MIL-68(Al) Metal-organic Framework for Effective Adsorption of Arsenate (As(V))
Authors: Rahmani Alireza , Shabanloo Amir , Zabihollahi Solmaz , Salari Mehdi , Leili Mostafa , Khazaei Mohammad , Alizadeh Saber , Nematollahi Davood 
Published: January 2022

Abstract
An amino-functionalized MIL-68(Al) metal-organic framework (amino-MIL-68(Al) MOF) was synthesized by solvothermal method and then characterized by FESEM, XRD, FTIR, EDX-mapping, and BET-BJH techniques. In order to predict arsenate (As(V)) removal, a robust quadratic model (R2 > 0.99, F-value = 2389.17 and p-value < 0.0001) was developed by the central composite design (CCD) method and then the genetic algorithm (GA) was utilized to optimize the system response and four independent variables. The results showed that As(V) adsorption on MOF was affected by solution pH, adsorbent dose, As(V) concentration and reaction time, respectively. Predicted and experimental As(V) removal efficiencies under optimal conditions were 99.45 and 99.87 %, respectively. The fitting of experimental data showed that As(V) adsorption on MOF is well described by the nonlinear form of the Langmuir isotherm and pseudo-second-order kinetic. At optimum pH 3, the maximum As(V) adsorption capacity was 74.29 mg/g. Thermodynamic studies in the temperature range of 25 to 50 °C showed that As(V) adsorption is a spontaneous endothermic process. The reusability of MOF in ten adsorption/regeneration cycles was studied and the results showed high reusability of this adsorbent. The highest interventional effect in inhibiting As(V) adsorption was related to phosphate anion. The results of this study showed that amino-MIL-68(Al) can be used as an effective MOF with a high surface area (> 1000 m2/g) and high reusability for As(V)-contaminated water.
H3.3K27M Mutation Promotes The Migration and Invasion of Glioma Cells By Activating β-Catenin/USP1 Signaling
Authors: Sun Zhiyuan , Zhu Yufu , Feng Xia , Liu Xiaoyun , Zhou Kunlin , Shi Hengliang 
Published: January 2022

Abstract
H3.3K27M is a newly identified molecular pathology marker in glioma and is especially correlated with the malignancy of diffuse intrinsic pontine glioma (DIPG). In recent years, accumulating research has revealed that other types of glioma also contain the H3.3K27M mutation. However, the role of H3.3K27M in high-grade adult glioma, which is the most malignant glioma, has not been investigated. In this study, we focused on exploring the expression and function of H3.3K27M in high-grade adult glioma patients. We found that H3.3K27M is partly highly expressed in high-grade glioma tissues. Then, we introduced H3.3K27M into H3.3 wild-type glioma cells, U87 cells and LN229 cells. We found that H3.3K27M did not regulate the growth of glioma in vitro and in vivo; however, the survival of mice with transplanted tumors was significantly reduced. Further investigation revealed that H3.3K27M expression mainly promoted the migration and invasion of glioma cells. Moreover, we certified that H3.3K27M overexpression enhanced the protein levels of ꞵ-catenin and p-ꞵ-catenin, the protein and mRNA levels of ubiquitin-specific protease 1 (USP1), and the protein level of enhancer of zeste homolog 2 (EZH2). Importantly, the ꞵ-catenin inhibitor XAV-939 significantly attenuated the upregulation of the aforementioned proteins. Overall, the H3.3K27M mutation is present in a certain proportion of high-grade glioma patients and facilitates a poor prognosis by promoting the metastasis of glioma by regulating the ꞵ-catenin/USP1/EZH2 pathway.
WITHDRAWN: Control of the COVID-19 System by Vaccination Using a New Control Engineering Technique
Authors: Ali Hazem Ibrahim , Mhmood Ali Hassan 
Published: January 2022

Abstract
In this work, a novel control engineering method is proposed to achieve a control strategy by vaccination for the COVID-19 epidemic. A proper mathematical model with vaccination control is developed for the COVID-19 system based on the Susceptible-Exposed-Infectious-Recovered (SEIR) epidemiological model after conducting some analyses and assumptions that reflect the COVID-19 features. Then, the proposed control law is designed using the feedback linearization approach and the H-infinity control framework. In addition, a model reference control is incorporated to ensure that satisfactory time responses are obtained. The Black Hole Optimization (BHO) technique is used to attain the optimality of the proposed control method. Following that, the reported statistics and vaccination plan of the Lombardy region of Italy are utilized to assess the effectiveness of the proposed control law. Ultimately, the simulation results illustrate that the proposed control law can effectively control the COVID-19 system and correctly perform the vaccination plan by tackling the system’s nonlinearity and uncertainty and realizing elegant asymptotic tracking characteristics with reasonable control effort.
Use of Space by Black-and-Gold Howler Monkeys (Alouatta caraya) in an Urban Environment in Paraguay.
Authors: Duffy Xander , Wellian Jake , Smith Rebecca L. 
Published: January 2022

Abstract
As urbanisation continues to reduce the available habitat for wildlife some species, such as the black-and-gold howler monkey (Alouatta caraya) in Pilar, southwest Paraguay, are making their homes in anthropogenic environments. Understanding an animal's home range is an important first step to understanding its ecological needs, an essential requirement for robust conservation plans. In this study we determined the home ranges and core areas of five groups of urban dwelling A. caraya using Minimum Convex Polygon (MCP) and Kernel Density Estimation (KDE) Analysis. We used a Spearman’s Correlation to explore the relationship between home range size and group size. All five groups had home ranges of less than 10 ha and used core areas of less than 1ha. Group size had no significant relationship to home range size. We provide the first estimates of home range for A. caraya in an urban environment in Paraguay. Though the home ranges of the urban A. caraya in Pilar, Paraguay fall at the smaller end of the spectrum of range sizes in Alouatta they are not abnormal for a species in this genus.
Numerical Modelling of Carrier Transport in Organic Field Effect Transistors
Authors: Hussien Salma A. , Abdullatif Sameh O. 
Published: January 2022

Abstract
Organic field effect transistors (OFETs), used in the fabrication of nano-sensors, are one of the most promising devices in the field of organic electronics, because of their light weight, flexible and low fabrication cost. However, the optimization of such OFETs is still in an early stage due to the very limited analytical as well as numerical models presented in the literature. This research presses to demonstrate a numerical carrier transport model based on finite element method (FEM), to investigate the I-V characteristic of OFETs. Two various organic semiconductor materials have been included in the study, polyaniline and pentacene, where a micro-scale as well as a nano-scale models have been presented. OFETs have been studied in terms of channel length, dielectric thickness, and doping level impact. We nominated the threshold voltage, the on/off current ratio, the sub threshold swing, and the field effect mobility’s as the main output evaluating parameters. The numerical model has shown the criticality of the doping effect on tuning the device flowing drain current, to exceed 300 μA saturation current, along with threshold voltage of -0.1 V under a channel length of 30 nm. Additionally, the study highlights the effectiveness of the polyaniline over pentacene as nano-channel length OFET, due to the boosted conductivity of polyaniline with respect to pentacene.
Utility of Indocyanine Green Videoangiography with FLOW 800 Analysis in Brain Tumor Resection - Venous Protection Tchnique
Authors: sun yue , Wang Zilan , Jiang Fan , Yang Xingyu , Tan Xin , Chen Zhouqing , Liu Yanfei , Zhu Yun , Wang Zhong 
Published: January 2022

Abstract
Background: When it comes to central nervous system tumor resection, preserving vital venous structures to avoid devastating consequences such as brain edema and hemorrhage is important. Wheras, in clinical practice, it is difficult to obtain clear and vivid intraoperative venous visualization and blood flow analysis.Methods: We retrospectively reviewed patients underwent brain tumor resection through the application of indocyanine green videoangiography (ICG-VA) integrated with FLOW 800 from February 2019 to December 2020 and presented our clinical cases to demonstrate the process of venous preservation. Galen vein, sylvian vein and superior cerebral veins were included in our cases.Results: Clear documentations of the veins from different venous groups were obtained via ICG-VA integrated with FLOW 800, which semiquantitatively analyzed the flow dynamics. ICG-VA integrated with FLOW 800 enabled us to achieve brain tumor resection without venous injury and obstructing the venous flux.Conclusions: ICG-VA integrated with FLOW 800 is an available method for venous preservation, though further comparison between ICG-VA integrated with FLOW 800 and other techniques of intraoperative blood flow monitoring is needed.
Night-eating, Overweight/obesity and Sleep Quality
Authors: Eid Shireen Walid , Brown Rhonda , Maloney Shane , Birmingham Carl Laird 
Published: January 2022

Abstract
PurposeImpaired sleep has been reported to be a consequence of overweight/obesity. However, sleep-disrupting behaviour that tend to coexist with overweight/obesity are also independent risk factors for impaired sleep such as night-eating, alcohol use, insufficient physical activity (PA), electronic device use and stress/affective distress. Thus, it is unclear whether night-eating and measures of body fatness will still predict sleep quality once concurrent behaviour and affective state are taken into account. MethodsOnline questionnaires asked participants about sleep quality, night-eating, alcohol use, electronic device use and stress/affective distress at T1 (baseline) and T2 (3-months later). Height, weight and waist and hip circumference was measured at T1 and objective physical activity (PA) was assessed over 24-hours (using actigraphy) in 161 participants at T1 and T2. ResultsAt T1, night-eating was related to poorer subjective sleep quality, longer sleep onset latency, lower sleep efficacy, more sleep disturbances and daytime dysfunction and obesity category was related to daytime dysfunction after controlling demographics and covariates. At T2, high BMI predicted lower sleep efficacy after controlling T1 sleep components, demographics and covariates. ConclusionNight-eating and obesity category were associated with multiple impairments in sleep quality, but only high BMI predicted sleep quality at T2. Thus, night-eating and measures of body fatness predicted sleep quality components at T1 and T2 even after co-existing behaviour and emotional states were taken into account.Level of EvidenceLevel III, evidence obtained from well-designed cohort.
Unraveling microRNA Mediated Gene Regulation in Centella asiatica (L.) Urb. by High-throughput Sequencing based Small-RNA Profiling.
Authors: Ranjith Gouri Priya , Satheesan Jisha , Sabu K K 
Published: January 2022

Abstract
Centella asiatica is a widely spread herb mostly found in the tropics having extensive medicinal values. Here, we report for the first time, transcriptome-wide characterization of miRNA profile from the leaves of C. asiatica using high-throughput Illumina sequencing. We identified 227 conserved and 109 putative novel miRNAs. Computational screening revealed potential mRNA targets for both the conserved and novel miRNAs encoding diverse transcription factors and enzymes involved in plant development, disease resistance, metabolic and signaling pathways. Gene ontology annotation and KEGG analysis revealed the miRNA targets to be involved in a wide range of metabolomic and regulatory pathways. The differential expression of the miRNA encoding genes in diverse tissues was determined by real-time PCR analysis. We also found that gene expression levels of miR156, 159 and 1171 was reduced in salicylic acid treated axenic shoot cultures of C. asiatica compared to its control. Furthermore, RLM-RACE experiments mapped miRNA-mediated cleavage at two of the mRNA targets. The present study represents the large-scale identification of microRNAs from C. asiatica and contributes to the base for the up-coming studies on miRNA-mediated gene regulation of plant secondary metabolite pathways in particular.
Orthodontics on sale: fixed appliances on E-commerce platforms
Authors: Kamarudin Yasmin , Zakaria Nor Nadia , Xinhui Violette Ong 
Published: January 2022

Abstract

Introduction
The sale of orthodontic materials, considered as medical devices, is regulated in order to protect patients. The availability of orthodontic products on e-commerce platforms, however, may go unregulated and compromise patient safety.

Objective
The present study aimed to investigate the sale of fixed orthodontic appliances on a local and global e-commerce platform.

Materials and Methods
A cross-sectional analysis of orthodontic materials sold on Shopee and Amazon was conducted using a specific keyword search for brackets, arch wires and ligatures. After deleting duplicates and irrelevant search results, the top 50 products for each keyword search were analysed. Product name, the type of product, seller, cost, star rating, the number of reviews, the number of sales, shipping location and brand identification were recorded. Brand registration with a medical device regulatory authority was checked. Collected data were tabulated in Google (spread)sheet to derive descriptive statistics and frequency tables.

Results
A total of 800 search results were screened. Three hundred and forty-eight relevant results were identified, approximately two-thirds of which originated from Shopee. Ligatures generated the highest search outcome in both Shopee (39%) and Amazon (80%). Fixed orthodontic materials sold on Shopee resulted in a larger number of reviews, higher star ratings and a lower cost per item compared to those supplied by Amazon. Products on Amazon were more likely to have brand identification (97%) compared to Shopee (5%). None of the identifiable brands on Shopee were registered with regulatory bodies, whereas eight products listed on Amazon were registered. A large portion of shipping locations originated from China for both e-commerce platforms.

Conclusions
Orthodontic brackets, arch wires and ligatures are more readily available on Shopee compared to Amazon. The quality and safety of these products cannot be assured as the majority of the products were either not clearly labelled or their registration was not identified under the regulation of medical devices.
Water-food-energy nexus for transboundary cooperation in Eastern Africa
Authors: Elsayed Hamdy , Djordjevic Slobodan , Savic Dragan , Tsoukalas Ioannis , Makropoulos Christos 
Published: January 2022

Abstract
Establishing cooperation in transboundary rivers is challenging especially with the weak or non-existent river basin institutions. A nexus-based approach is developed to explore cooperation opportunities in transboundary river basins while considering system operation and coordination under uncertain hydrologic river regimes. The proposed approach is applied to the Nile river basin with a special focus on the Grand Ethiopian Renaissance Dam (GERD), assuming two possible governance positions: with or without cooperation. A cooperation mechanism is developed to allocate additional releases from the GERD when necessary, while a unilateral position assumes that the GERD is operated to maximize hydropower generation regardless of downstream users' needs. The GERD operation modes were analysed considering operation of downstream reservoirs and varying demands in Egypt. Results show that average basin-wide hydropower generation is likely to increase by about 547 GWh/year (1%) if cooperation is adopted when compared to the unilateral position. In Sudan, hydropower generation and water supply are expected to enhance in the unilateral position and would improve further with cooperation. Furthermore, elevated low flows by the GERD are likely to improve the WFE nexus outcomes in Egypt under full cooperation governance scenario with a small reduction in GERD hydropower generation (2,000 GWh/year (19%)).
The Role of Natural Products in Treatment of Depressive Disorder
Authors: Noori Tayebeh , Sureda Antoni , Sobarzo-Sánchez Eduardo , Shirooie Samira 
Published: January 2022

Abstract:
Depressive disorder is one of the most common psychiatric syndromes that, if left untreated,
can cause many disturbances in a person's life. Numerous factors are involved in depression,
including inflammation, brain-derived neurotrophic factor (BDNF), GABAergic system, hypothalamic–
pituitary–adrenal (HPA) Axis, monoamine neurotransmitters (serotonin (5-HT), noradrenaline,
and dopamine). Common treatments for depression are selective serotonin reuptake inhibitors,
tricyclic antidepressants, and monoamine oxidase inhibitors, but these drugs have several side effects
such as anxiety, diarrhea, constipation, weight loss, and sexual dysfunctions. These agents only
reduce the symptoms and temporarily reduce the rate of cognitive impairment associated with depression.
As a result, extensive research has recently been conducted on the potential use of antidepressant
and sedative herbs. According to the available data, herbs used in traditional medicine can
be significantly effective in reducing depression, depressive symptoms and improving patients' performance.
The present study provides a summary of biomarkers and therapeutic goals of depression
and shows that natural products such as saffron or genipin have antidepressant effects. Some of the
useful natural products and their mechanisms were evaluated. Data on various herbs and natural isolated
compounds reported to prevent and reduce depressive symptoms is also discussed.