bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Cytoskeletal Action of Xylosides
Authors: Mencio Caitlin P. , Tilve Sharada , Suzuki Masato , Higashi Kyohei , Katagiri Yasuhiro , Geller Herbert M. 
Published: February 2022

AbstractProteoglycan glycosaminoglycan (GAG) chains are attached to a serine residue in the protein through a linkage series of sugars, the first of which is xylose. Xylosides are chemicals which compete with the xylose at the enzyme xylosyl transferase to prevent the attachment of GAG chains to proteins. These compounds have been employed at concentrations in the millimolar range as tools to study the role of GAG chains in proteoglycan function. In the course of our studies with xylosides, we conducted a dose-response curve for xyloside actions on neural cells. To our surprise, we found that concentrations of xylosides in the nanomolar to micromolar range had major effects on cell morphology. These effects are due to changes in cytoskeletal dynamics. Concentrations of xylosides which were effective in altering morphology did not alter GAG chain synthesis rates, nor did they produce any changes in gene expression as determined by RNAseq of treated cells. These observations support a novel action of xylosides on neuronal cells.
Volumetric development of hippocampal subfields and hippocampal white matter connectivity: Relationship with episodic memory
Authors: Dick Anthony Steven , Ralph Yvonne , Farrant Kristafor , Reeb-Sutherland Bethany , Pruden Shannon , Mattfeld Aaron T. 
Published: February 2022

AbstractThe hippocampus is a complex structure composed of several distinct subfields and has been at the center of scientific study examining the neural foundations of episodic memory. To date, there is little consensus regarding the structural development of the hippocampus and its subfields assessed both volumetrically and through anatomical connectivity, nor how the development of the related substructures influences episodic memory. In the current cross-sectional study, using a large sample of 830, 3- to 21-year-olds from a unique and publicly available dataset we examined the following questions: 1) Is there elevated grey matter volume of the hippocampus and its respective subfields in late compared to early development? 2) How does hippocampal volume compare with the rest of the cerebral cortex at different developmental stages? and 3) What is the relation between hippocampal volume, and the connectivity of the hippocampus with cortex as measured by diffusion-weighted imaging, with episodic memory performance? We found hippocampal subfield volumes exhibited a non-linear relation with age. Specifically, hippocampal subfield volumes showed a lag in volumetric change with age when compared to adjacent cortical regions (e.g., entorhinal cortex). We also observed a significant reduction in cortical volume across older cohorts, while hippocampal volume showed the opposite pattern. In addition to age-related differences in grey matter volume, several distinct subfields are significantly related to episodic memory. We did not, however, find any associations with episodic memory performance and connectivity through the uncinate fasciculus, fornix, or cingulum. The results are discussed in the context of current research and theories of hippocampal development and its relation to episodic memory.
Exploring relationship among semiotic product packaging, brand experience dimensions, brand trust and purchase intentions in an Asian emerging market
Authors: Shukla Mahima , Misra Richa , Singh Deepak 
Published: February 2022

PurposeOver recent years, brand semiotics have been gaining the marketing practitioners' attention for designing their brand strategy. Hence, to address this gap, the current study investigates the effect of semiotic product packaging on brand experience dimensions, brand trust and purchase intent of reputed major brands of fast-moving consumer good (FMCG) products.Design/methodology/approachThe data for this study were collected by administering a questionnaire-based survey from 254 respondents from the Delhi National Capital Region (NCR) of India, using systematic sampling. Structural equation modeling has been used to test the conceptual model and examine the hypotheses developed in the study.FindingsThe results present evidence of the growing influence of semiotic product packaging upon consumer brand trust and purchase intentions. The study suggests that brand semiotics positively influence customer brand experience, brand trust and purchase intention of FMCG products.Practical implicationsThe research findings will benefit FMCG companies to identify how to apply semiotics in packaging to improve consumers' brand experience and influence intent to purchase.Originality/valueResearch in brand semiotics on product packaging is limited, as most prior studies focus on brand semiotics in advertising, product design improvement and retail design. The present study has investigated the impact of semiotics on brand experience dimensions in product packaging, which is emerging as a critical concern for the FMCG sector particularly in the post-COVID period.
Working mothers in East and West Germany: a cluster analysis using a three-stage approach
Authors: Ziegler Yvonne , Graml Regine , Khachatryan Kristine , Uli Vincenzo 
Published: February 2022

PurposeThe second Frankfurt Career Study was conducted in 2017 in East and West Germany to analyze the impact of motherhood on female professional advancement in the specific national context of Germany. In addition, this study aims to present a unique perspective of the similarities and dissimilarities between the Western and Eastern parts of the country.Design/methodology/approachThe research is presented as a three-stage statistical approach based on quantitative data generated from a survey conducted among 2,130 working mothers. In the first step, the authors performed a multiple correspondence analysis to explore the relationships between important categorical variables. Using the object scores obtained in the first step, we then ran a hierarchical cluster analysis, followed by the third and last step: using the k-means clustering method to partition the survey respondents into groups.FindingsThe authors found that working mothers in Germany are distributed according to four clusters mainly described by demographics and orientation toward work. East Germany has been found as a more egalitarian context than West Germany with respect to family system arrangements. However, the upper bound of the sample in West Germany presented an atypical female breadwinner model in high-performance households.Originality/valueThe authors want to contribute to previous investigations on the topic by providing a more comprehensive view of the phenomenon, especially comparing the two different family systems and social norms from the Eastern and Western parts of the country. The authors ask whether and how career perspectives and female labor supply are influenced by drivers such as work–family conflict determinants, working mothers demographics, partner support and employer support.
COVID-19 health misinformation: using design-based research to develop a theoretical framework for intervention
Authors: Houlden Shandell , Veletsianos George , Hodson Jaigris , Reid Darren , Thompson Christiani P. 
Published: February 2022

PurposeBecause health misinformation pertaining to COVID-19 is a serious threat to public health, the purpose of this study is to develop a framework to guide an online intervention into some of the drivers of health misinformation online. This framework can be iterated upon through the use of design-based research to continue to develop further interventions as needed.Design/methodology/approachUsing design-based research methods, in this paper, the authors develop a theoretical framework for addressing COVID-19 misinformation. Using a heuristic analysis of research on vaccine misinformation and hesitancy, the authors propose a framework for education interventions that use the narrative effect of transportation as a means to increase knowledge of the drivers of misinformation online.FindingsThis heuristic analysis determined that a key element of narrative transportation includes orientation towards particular audiences. Research indicates that mothers are the most significant household decision-makers with respect to vaccines and family health in general; the authors suggest narrative interventions should be tailored specifically to meet their interests and tastes, and that this may be different for mothers of different backgrounds and cultural communities.Originality/valueWhile there is a significant body of literature on vaccine hesitancy and vaccine misinformation, more research is needed that helps people understand the ways in which misinformation works upon social media users. The framework developed in this research guided the development of an education intervention meant to facilitate this understanding.
Implementing a strategic campus-wide approach to authentic assessment: considerations and recommendations for implementation
Authors: Brown Melanie , Nomikoudis Milton , Bouilheres Frederique , Nkhoma Clara , Akbari Mohammadreza 
Published: February 2022

PurposeThis article addresses the experience of academic developers and academic staff during the transition of assessment practices in an English-speaking international university campus in South East Asia. The project examined in the study was born out of the institutional strategy focused on producing graduates ready for employment.Design/methodology/approachA case study from a Business discipline highlights key factors in curricula change from the academic perspective.FindingsThis study focuses on what it meant for the academic teaching and academic development teams to work together to bridge the broadly strategic with the local practical implementation. Potential implications for others embarking on academic development within large-scale strategic projects are also provided.Originality/valueThis paper offers a discussion of the symbiotic relationship between management, academic staff and academic developers (Roxå and Mårtensson, 2008) generated by the transition to authentic assessment as a key element in the development of student employability.
Service learning in Indonesia: developing undergraduate students' leadership during COVID-19 pandemic
Authors: Ferdiansyah Sandi , Winarno Ahmad , Ardhita Zally 
Published: February 2022

PurposeThis phenomenological case study reports how 16 participating students built their leadership skill through a community-based service-learning project as a part of their undergraduate program at an Islamic university in Indonesia. Education for sustainability framework promoted by Warwick (2016) was employed to portray students' leadership development and explore their lived experience while doing service-learning project in their neighborhood.Design/methodology/approachPhenomenological case study was employed to portray how the participants engaged in projects that empower the community during their service amidst the coronavirus disease 2019 (COVID-19) pandemic. They were interviewed using online platforms such as WhatsApp and Zoom Meeting. To triangulate the data, the photos elicited during their field study posted in social media were also presented as visual data. The interview data and photo elicitation were transcribed, interpreted using interpretative phenomenological analysis and thematically analyzed.FindingsThe findings of the study showcase that the student participants transformed their sense of agency as learners into leaders. The service-learning program has also become a springboard for them to engage in the community service and build strategy to fill the local community's need, especially amid the pandemic of COVID-19.Research limitations/implicationsThere are two limitations in regards to this study. First, this study only examined data garnered from a small number of participants that could not be used to overgeneralize the results of the study. Second, the participants were interviewed upon the completion of their service-learning project. It did not investigate the sustainability of the projects that the participants had carried out after the service-learning program ended.Originality/valueWhile ample previous studies investigated how service-learning program that involved undergraduate students were enacted during COVID-19 pandemic, the present study specifically looked into how participants exercise their leadership skill upon the implementation of service-learning from education for sustainability framework promoted by Warwick (2016).
Time-efficiency factors in road tunnel rescue as perceived by Swedish operative personnel – an interview study
Authors: Hylander Johan , Saveman Britt-Inger , Björnstig Ulf , Gyllencreutz Lina , Westman Anton 
Published: February 2022

PurposeMajor incidents in road tunnels remain a collaborative challenge for the emergency services (fire and rescue service, police and ambulance), emergency dispatch centres (EDCs) and infrastructure owners. The aim of this paper is to investigate how collaborative partners to the ambulance services perceive the rescue effort and to identify factors that may influence its efficiency.Design/methodology/approachFocus group and individual interviews were conducted with 19 participants who were infrastructure owners or had operational or tactical responsibilities with the emergency services or EDCs in two regions in Sweden with multiple road tunnels. The collected data were analysed using qualitative content analysis.FindingsThree main categories described efficiency factors during and after an incident: (1) coordinating the initial information (using a shared terminology), (2) achieving situational awareness (identifying those persons in need) and (3) lessons (not) learnt (lack of joint tactical plans and exercises). The emerging theme was access, assess and evaluate.Practical implicationsThe findings suggest that establishing national policies and collaborative forums might yield more efficiently managed rescue efforts in road tunnel incidents in Sweden and other countries with similar organisational structures.Originality/valueThis study offers new insights on interoperability during responses to complex underground incidents.
How do marital formation and dissolution differ across employment statuses? Analysis of Japanese non‐regular employees
Authors: Esteban‐Pretel Julen , Fujimoto Junichi 
Published: February 2022

AbstractOver time, Japan has seen an increase in non‐regular employment and a shift away from marriage. To uncover any link between these issues, this paper uses Japanese Labour Force Survey microdata to examine annual transitions between marital statuses and how such transitions vary across labour market statuses, in particular between male regular and non‐regular employees. We find, for different age groups, that the odds ratio of marriage for male non‐regular employees is 30% to 40% lower than that for male regular employees even after controlling for education. We also find that the odds ratio of divorce for married couples is twice as large when the husband is a non‐regular employee than when the husband is a regular employee. Our analysis sheds light on the challenges faced by Japanese males with non‐regular jobs in enjoying stable marital relationships and it reveals the regional heterogeneity of such challenges.
Horner syndrome after cervical spine corticosteroid injection
Authors: Hassold Nolan , Pina Vegas Laura , Jelin Germain , Forien Marine , Palazzo Elisabeth , Dieudé Philippe , Ottaviani Sébastien 
Published: February 2022

AbstractHorner syndrome is a rare condition caused by a lesion of the sympathetic cervical chain. Multiple cervical disorders are associated with such lesions. Here we report the first case of Horner syndrome after cervical facet joint corticosteroid injection.
When Does Transparency Improve Institutional Performance? Evidence from 20,000 Projects in 183 Countries
Authors: Honig Dan , Lall Ranjit , Parks Bradley C. 
Published: February 2022

AbstractAccess to information (ATI) policies are often praised for strengthening transparency, accountability, and trust in public institutions, yet evidence that they improve institutional performance is mixed. We argue that an important impediment to the effective operation of such policies is the failure of bureaucrats to comply with information requests that could expose poor performance. Analyzing a new data set on the performance of approximately 20,000 aid projects financed by 12 donor agencies in 183 countries, we find that enforcement matters: the adoption of ATI policies by agencies is associated with better project outcomes when these policies include independent appeals processes for denied information requests but with no improvement when they do not. We also recover evidence that project staff adjust their behavior in anticipation of ATI appeals, and that the performance dividends of appeals processes increase when bottom‐up collective action is easier and mechanisms of project oversight are weak.
Cannabis‐related allergies: An international overview and consensus recommendations
Authors: Skypala Isabel J. , Jeimy Samira , Brucker Hannelore , Nayak Ajay P. , Decuyper Ine I. , Bernstein Jonathan A. , Connors Lori , Kanani Amin , Klimek Ludger , Lo Shun Chi Ryan , Murphy Kevin R. , Nanda Anil , Poole Jill. A. , Walusiak‐Skorupa Jolanta , Sussman Gordon , Zeiger Joanna S. , Goodman Richard E. , Ellis Anne K. , Silvers William S. , Ebo Didier G. ,   The International Cannabis Allergy Collaboration
Published: February 2022

AbstractCannabis is the most widely used recreational drug in the world. Cannabis sativa and Cannabis indica have been selectively bred to develop their psychoactive properties. The increasing use in many countries has been accelerated by the COVID‐19 pandemic. Cannabis can provoke both type 1 and type 4 allergic reactions. Officially recognized allergens include a pathogenesis‐related class 10 allergen, profilin, and a nonspecific lipid transfer protein. Other allergens may also be relevant, and recognition of allergens may vary between countries and continents. Cannabis also has the potential to provoke allergic cross‐reactions to plant foods. Since cannabis is an illegal substance in many countries, research has been hampered, leading to challenges in diagnosis since no commercial extracts are available for testing. Even in countries such as Canada, where cannabis is legalized, diagnosis may rely solely on the purchase of cannabis for prick‐to‐prick skin tests. Management consists of avoidance, with legal issues hindering the development of other treatments such as immunotherapy. Education of healthcare professionals is similarly lacking. This review aimed to summarize the current status of cannabis allergy and proposes recommendations for the future management of this global issue.
Damage in hidradenitis suppurativa: a narrative review emphasizing the need for a novel outcome measure
Authors: Fritsche Madelaine , Okun Martin , Kirby Joslyn S. 
Published: February 2022

Abstract

Cutaneous damage caused by hidradenitis suppurativa (HS) is an important contributor to disease burden, independent of active lesions. Outcome measures used to specifically assess damage are becoming commonplace in the assessment of inflammatory diseases. However, no standardized method for assessing HS damage currently exists. The purpose of this study was to review outcome measures in HS that include constructs of both active disease and damage, review damage-specific instruments used in other inflammatory and destructive diseases, and review instruments used to assess scars of various aetiologies. This ultimately provides insight into how attributes of different tools can be applied to develop an outcome measure specific to HS damage.
What is already known about this topic? Hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin condition, which causes consequent cutaneous damage and scarring. Damage caused by HS is highly prevalent and an important contributor to its morbidity. Damage is an important component of inflammatory diseases that has proven its utility in a number of outcome measures; however, no standardized method for assessing HS damage currently exists.
What does this study add? This narrative review assesses outcome measures used to measure damage in other inflammatory and destructive diseases. Instruments used to assess damage in other diseases can provide a starting point for the development of a damage outcome measure for HS.
Paclitaxel in vitro reversibly sensitizes the excitability of IB4(−) and IB4(+) sensory neurons from male and female rats
Authors: Villalba‐Riquelme Eva , de la Torre‐Martínez Roberto , Fernández‐Carvajal Asia , Ferrer‐Montiel Antonio 
Published: February 2022

Background and PurposePaclitaxel produces a chemotherapy‐induced peripheral neuropathy that persists in 50–60% of cancer patients upon treatment. Evidence from animal models suggests an axonopathy of peripheral A‐ and C‐type fibres that affects their excitability. However, direct effects of paclitaxel on sensory neuron excitability and sexual dimorphism remain poorly understood.Experimental ApproachWe used a long‐lasting (10 days in vitro) primary culture of rat dorsal root ganglion (DRG) neurons to investigate the time course effect of paclitaxel on the electrical activity of IB4(−) and IB4(+) sensory neurons of female and male adult Wistar rats.Key ResultsPaclitaxel strongly and reversibly stimulated spontaneous activity and augmented action potential tonic firing in IB4(−) and IB4(+) neurons in both sexes, peaking at 48 h post‐treatment and virtually disappearing at 96 h. Paclitaxel decreased the current rheobase for action potential firing by reducing and accelerating the after‐hyperpolarization phase. Molecularly, paclitaxel modulated Na+ and K+ ion currents. Particularly, the drug significantly augmented the function of Nav1.8, TRPV1 and TRPM8 channels. Furthermore, paclitaxel increased Nav1.8 and TRPV1 expression at 48 h post‐treatment. Notably, we observed that female DRG neurons appear more sensitive to paclitaxel sensitization than their male counterparts.Conclusions and ImplicationsOur data indicate that paclitaxel similarly potentiated IB4(−) and IB4(+) electrogenicity and uncover a potential sex dimorphism in paclitaxel‐induced chemotherapy‐induced peripheral neuropathy. Our in vitro, pre‐clinical, chemotherapy‐induced peripheral neuropathy paradigm provides a tool for studying the dynamics and underlying molecular mechanisms contributing to nociceptor sensitization in peripheral neuropathies and for testing desensitizing compounds.
Real‐Time Microstructure Rendering with MIP‐Mapped Normal Map Samples
Authors: Tan Haowen , Zhu Junqiu , Xu Yanning , Meng Xiangxu , Wang Lu , Yan Ling‐Qi 
Published: February 2022

AbstractNormal map‐based microstructure rendering can generate both glint and scratch appearance accurately. However, the extra high‐resolution normal map that defines every microfacet normal may incur high storage and computation costs. We present an example‐based real‐time rendering method for arbitrary microstructure materials, which significantly reduces the required storage space. Our method takes a small‐size normal map sample as input. We implicitly synthesize a high‐resolution normal map from the normal map sample and construct MIP‐mapped 4D position‐normal Gaussian lobes. Based on the above MIP‐mapped 4D lobes and a LUT (lookup table) data structure for the synthesized high‐resolution normal map, an efficient Gaussian query method is presented to evaluate ‐NDFs (position‐normal distribution functions) for shading. We can render complex scenes with glint and scratch surfaces in real time (30 fps) with a full high‐definition resolution, and the space required for each microstructure material is decreased to 30 MB.