bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward a generalized developmental model of psychopathological liabilities and psychiatric disorders
Authors: Blanco Carlos , Wall Melanie M. , Hoertel Nicolas , Krueger Robert F. , Olfson Mark 
Published: February 2022

AbstractBackgroundMost psychiatric disorders are associated with several risk factors, but a few underlying psychopathological dimensions account for the common co-occurrence of disorders. If these underlying psychopathological dimensions mediate associations of the risk factors with psychiatric disorders, it would support a trans-diagnostic orientation to etiological research and treatment development.MethodAn analysis was performed of the 2012–2013 National Epidemiologic Survey on Alcohol and Related Conditions III (NESARC-III), a US nationally representative sample of non-institutionalized civilian adults, focusing on respondents who were aged ⩾21 (n = 34 712). Structural equation modeling was used to identify the psychopathological dimensions underlying psychiatric disorders; to examine associations between risk factors, psychopathological dimensions and individual disorders; and to test whether associations of risk factors occurring earlier in life were mediated by risk factors occurring later in life.ResultsA bifactor model of 13 axis I disorders provided a good fit (CFI = 0.987, TLI = 0.982, and RMSEA = 0.011) including an overall psychopathology factor as measured by all 13 disorders and 2 specific factors, one for externalizing disorders and one for fear-related disorders. A substantial proportion of the total effects of the risk factors occurring early in life were indirectly mediated through factors occurring later in life. All risk factors showed a significant total effect on the general psychopathology, externalizing and fear-related factors. Only 23 of 325 direct associations of risk factors with psychiatric disorders achieved statistical significance.ConclusionMost risk factors for psychiatric disorders are mediated through broad psychopathological dimensions. The central role of these dimensions supports trans-diagnostic etiological and intervention research.
Multimodal meta-analysis of structural gray matter, neurocognitive and social cognitive fMRI findings in schizophrenia patients
Authors: Picó-Pérez Maria , Vieira Rita , Fernández-Rodríguez Marcos , De Barros Maria Antónia Pereira , Radua Joaquim , Morgado Pedro 
Published: February 2022

AbstractNeuroimaging research has shown that patients with schizophrenia (SCZ) present brain structural and functional alterations, but the results across imaging modalities and task paradigms are difficult to reconcile. Specifically, no meta-analyses have tested whether the same brain systems that are structurally different in SCZ patients are also involved in neurocognitive and social cognitive tasks. To answer this, we conducted separate meta-analyses of voxel-based morphometry, neurocognitive functional magnetic resonance imaging (fMRI), and social cognitive fMRI studies. Next, with a multimodal approach, we identified the common alterations across meta-analyses. Further exploratory meta-analyses were performed taking into account several clinical variables (illness duration, medication status, and symptom severity). A cluster covering the dorsomedial prefrontal cortex (dmPFC) and the supplementary motor area (SMA), and the right inferior frontal gyrus (IFG), presented shared structural and neurocognitive-related activation decreases, while the right angular gyrus presented shared decreases between structural and social cognitive-related activation. The exploratory meta-analyses replicated to some extent these findings, while new regions of alterations appeared in patient subgroups with specific clinical features. In conclusion, we found task-specific correlates of brain structure and function in SCZ, which help summarize and integrate a growing literature.
‘Daddy-callin’ Mamas’ and ‘Jelly Beans’: sex work and ribaldry in the blues archive
Authors: Curtis Bruce 
Published: February 2022

AbstractI present a thematic overview of sex work and ribaldry in recorded blues songs for the period c.1920–1942. My ambition is primarily documentary, to take up Paul Oliver's insistence that discussion of the blues must ultimately revolve around its ‘libidinous hub’ and to concretise Abbott and Seroff's characterisation of blues as ‘unabashedly licentious a music form as America has ever produced’. Ribald sex work songs are common in the blues archive, but have not been a focus of sustained study. A grasp of the significance of sex work provides a key to decoding creative wordplay, even as the relation between blues performers and real sex work must remain obscure.
Social justice and the judicial interpretation of international equal protection law
Authors: Altwicker Tilmann 
Published: February 2022

AbstractSocial justice is turning into an international concern. This development is a response to the continuous rise of socioeconomic inequality – the gap between the rich and the poor –growing in several OECD member states since the 1970s. International human rights law (IHRL) presently only establishes a weak normative framework regarding social justice. This article argues that the full potential of this framework has still not been activated by international human rights adjudication. There are several reasons for this: a complex history of ideas suggesting little common understanding of the notion of social justice, the focus of international human rights adjudication on individual rather than constitutional justice, and the priority of liberty rights over equality rights. Yet, the domination of the liberal over the social in international human rights adjudication has started to change. The article shows how the social justice concern is beginning to be incorporated into IHRL by judicial interpretation of international equal protection and non-discrimination law (international equal protection law, IEPL). Integrating the social justice concern into IEPL is a legitimate yet transformative step as it increases judicial discretion at the international level. More than many other human rights, socioeconomic equality is highly context-specific and depends on a complex factual assessment of the local circumstances. This exacerbates the institutional legitimacy challenge levelled against international human rights courts. However, the article argues that the legitimacy challenge can be alleviated by focusing more on procedural rather than a substantive international review.
Early childhood maltreatment and profiles of resilience among child welfare-involved children
Authors: Yoon Susan , Pei Fei , Logan Jessica , Helsabeck Nathan , Hamby Sherry , Slesnick Natasha 
Published: February 2022

AbstractGiven the high burden of child maltreatment, there is an urgent need to know more about resilient functioning among those who have experienced maltreatment. The aims of the study were to: 1) identify distinct profiles of resilience across cognitive, emotional, behavioral, and social domains in young children involved in the child welfare system; and 2) examine maltreatment characteristics and family protective factors in relation to the identified resilience profiles. A secondary analysis was conducted using data from the National Survey of Child and Adolescent Well-Being (NSCAW-II). Latent profile analysis was performed on a sample of 827 children aged 3–5 years (46% girls, Mean age = 3.96). Three distinct resilience profiles were identified: 1)low cognitive resilience(24%); 2)low emotional and behavioral resilience(20%); and 3)multidomain resilience(56%). Caregiver cognitive stimulation, no out-of-home placement, higher caregiver education level, older child age, and being a girl were associated with themultidomain resilienceprofile. The findings provide empirical support for the multifaceted nature of resilience and suggest that practitioners need to help children achieve optimal and balanced development by assessing, identifying, and targeting those domains in which children struggle to obtain competence.
Immediate maternal and fetal outcome following percutaneous mitral valve balloon commissurotomy: a 6-year single-center experience from sub-Saharan Africa
Authors: Sebah Mohammed Bedru , Mengistu Azene Dessie , Tadesse Kefelegn Dejene , Tekleab Atnafu Mekonnen 
Published: February 2022

AbstractBackground:Mitral stenosis is the most common valvular heart disease during pregnancy. When severe, it leads to significant maternal and fetal morbidity and mortality. Percutaneous mitral valve balloon commissurotomy can be performed during pregnancy, and the present study aimed to describe the immediate maternal and fetal outcomes after percutaneous mitral valve balloon commissurotomy was done in a cohort of 23 pregnant patients with severe mitral stenosis in Addis Ababa, Ethiopia.Methods:Included in the current study were all pregnant mothers who had severe rheumatic mitral valve stenosis and who underwent percutaneous mitral valve balloon commissurotomy at the Cardiac Center of Ethiopia over 6-year period. Data were collected through chart abstraction using a structured proforma and then analysed using STATA version 13.0.Result:Median gestational age was 22 weeks and percutaneous mitral valve balloon commissurotomy was successful resulting in a significant increase in the mean mitral valve area of the group from 0.78 ± 0.20 cm2 to 1.89 ± 0.31 cm2 (p < 0.001). The mean mitral valve inflow gradient of the group was 23.95 ± 6.27 mmHg and 6.80 ± 2.44 mmHg, respectively, before and after the percutaneous mitral valve balloon commissurotomy procedure (p < 0.001). Post-procedure, there was no significant increment in mitral valve incompetence. The mean pulmonary artery pressure of the group decreased from 77.68 ± 23.19 mmHg to 42.31 ± 9.95 mmHg (p < 0.001). There was no fetal or maternal death following the procedure. Pregnancy ended at term gestation for 19/23 (82.6%) of the mothers and the mean birth weight of the neonates was 2800 g.Conclusion:Percutaneous mitral valve balloon commissurotomy procedure can safely be done for severe symptomatic rheumatic mitral stenosis in pregnancy in our setting.
Family child care home providers’ self-reported nutrition and physical activity practices, self-efficacy, barriers and knowledge: baseline findings from happy healthy homes
Authors: Sisson Susan B , Eckart Erin , Williams Bethany D , Patel Sarah M , Kracht Chelsea L , Davis Holly A , Ward Dianne S , Hildebrand Deana , Stoner Julie A , Stinner Emily , Kerr Kelly E , Salvatore Alicia 
Published: February 2022

AbstractObjective:Describe nutrition and physical activity practices, nutrition self-efficacy and barriers and food programme knowledge within Family Child Care Homes (FCCH) and differences by staffing.Design:Baseline, cross-sectional analyses of the Happy Healthy Homes randomised trial (NCT03560050).Setting:FCCH in Oklahoma, USA.Participants:FCCH providers (n 49, 100 % women, 30·6 % Non-Hispanic Black, 2·0 % Hispanic, 4·1 % American Indian/Alaska Native, 51·0 % Non-Hispanic white, 44·2 ± 14·2 years of age. 53·1 % had additional staff) self-reported nutrition and physical activity practices and policies, nutrition self-efficacy and barriers and food programme knowledge. Differences between providers with and without additional staff were adjusted for multiple comparisons (P < 0·01).Results:The prevalence of meeting all nutrition and physical activity best practices ranged from 0·0–43·8 % to 4·1–16·7 %, respectively. Average nutrition and physical activity scores were 3·2 ± 0·3 and 3·0 ± 0·5 (max 4·0), respectively. Sum nutrition and physical activity scores were 137·5 ± 12·6 (max 172·0) and 48·4 ± 7·5 (max 64·0), respectively. Providers reported high nutrition self-efficacy and few barriers. The majority of providers (73·9–84·7 %) felt that they could meet food programme best practices; however, knowledge of food programme best practices was lower than anticipated (median 63–67 % accuracy). More providers with additional staff had higher self-efficacy in family-style meal service than did those who did not (P = 0·006).Conclusions:Providers had high self-efficacy in meeting nutrition best practices and reported few barriers. While providers were successfully meeting some individual best practices, few met all. Few differences were observed between FCCH providers with and without additional staff. FCCH providers need additional nutrition training on implementation of best practices.
PLURAL ANCESTRAL LOGIC AS THE LOGIC OF ARITHMETIC
Authors: TATTON-BROWN OLIVER 
Published: February 2022

AbstractNeo-Fregeanism aims to provide a possible route to knowledge of arithmetic via Hume’s principle, but this is of only limited significance if it cannot account for how the vast majority of arithmetic knowledge, accrued by ordinary people, is obtained. I argue that Hume’s principle does not capture what is ordinarily meant by numerical identity, but that we can do much better by buttressing plural logic with plural versions of the ancestral operator, obtaining natural and plausible characterizations of various key arithmetic concepts, including finiteness, equinumerosity and addition and multiplication of cardinality—revealing these to be logical concepts, and obtaining much of ordinary arithmetic knowledge as logical knowledge. Supplementing this with an abstraction principle and a simple axiom of infinity (known either empirically or modally) we obtain a full interpretation of arithmetic.
Design and analysis of circular microstrip patch probe array for precise specific absorption rate measurement at quad-band
Authors: Naik Bhukya Venkanna 
Published: February 2022

AbstractThis paper distinguishes the design and analysis of 3 × 2 circular microstrip patch probe array for specific absorption rate (SAR) measurement at quad-band. This novel approach consists of FR4 substrate radial dimension of 88 mm and it has six circular array elements with a radius of 17 mm; out of these six elements, three array elements are having rectangular slots with dimensions of 1.8 × 1.5 × 1.5 mm3. The array elements are coupled with six probes which have a dimension of 100 mm with a 2.5 mm tip radius; these six probes are embedded into a tissue-equivalent liquid-filled human head mannequin. In this mannequin, instantaneous SAR at any six positions has been investigated. The proposed design resonates at 1.8, 2.1, 2.4, and 2.5 GHz with a return loss of −11.53, −15.90, −15.73, and −25.49 dB. The circular microstrip probe array is fed by a 50 Ohm coaxial feed. In addition, the 3D human head model analysis is also presented. The precisely estimated SAR values are 0.135, 0.108, 0.167, and 0.244 W/kg at 1 g of tissue. For the traceable measurements, each source of uncertainty budget has been estimated.
Automatic Segmentation of Sinkholes Using a Convolutional Neural Network
Authors: Rafique Muhammad Usman , Zhu Junfeng , Jacobs Nathan 
Published: February 2022

AbstractSinkholes are the most abundant surface features in karst areas worldwide. Understanding sinkhole occurrences and characteristics is critical for studying karst aquifers and mitigating sinkhole‐related hazards. Most sinkholes appear on the land surface as depressions or cover collapses and are commonly mapped from elevation data, such as digital elevation models (DEMs). Existing methods for identifying sinkholes from DEMs often require two steps: locating surface depressions and separating sinkholes from non‐sinkhole depressions. In this study, we explored deep learning to directly identify sinkholes from DEM data and aerial imagery. A key contribution of our study is an evaluation of various ways of integrating these two types of raster data. We used an image segmentation model, U‐Net, to locate sinkholes. We trained separate U‐Net models based on four input images of elevation data: a DEM image, a slope image, a DEM gradient image, and a DEM‐shaded relief image. Three normalization techniques (Global, Gaussian, and Instance) were applied to improve the model performance. Model results suggest that deep learning is a viable method to identify sinkholes directly from the images of elevation data. In particular, DEM gradient data provided the best input for U‐net image segmentation models to locate sinkholes. The model using the DEM gradient image with Gaussian normalization achieved the best performance with a sinkhole intersection‐over‐union (IoU) of 45.38% on the unseen test set. Aerial images, however, were not useful in training deep learning models for sinkholes as the models using an aerial image as input achieved sinkhole IoUs below 3%.
Topographically Trapped Waves Around South America With Periods Between 40 and 130 Days in a Global Ocean Reanalysis
Authors: Poli Léa , Artana Camila , Provost Christine 
Published: February 2022

AbstractThe South American continental slope hosts a variety of topographic waves. We use a 27‐year‐long global ocean reanalysis (1/12° Spatial resolution) to examine trapped waves (TWs) around South America at periods ranging from 40 to 130 days. The waves propagate from the Equatorial Pacific to the Tropical Atlantic (22°S) with phase velocities between 1.8 and 7 m/s according to the local background characteristics, such as stratification, slope steepness, latitude, mean flow and shelf width. The Madden‐Julian Oscillation (MJO) plays a key role in forcing the TWs in two ways (a) through an oceanic connection implying equatorial Kelvin waves reaching the western American Coast and (b) through an atmospheric teleconnection enhancing southerly winds in the south‐east Pacific. Furthermore, local winds, not necessarily linked with the MJO, modulate and trigger waves in specific locations, such as the Brazil‐Malvinas Confluence. Trapped waves impact the along‐shore currents: during the positive phase of the waves the near‐surface flow is enhanced by about 0.1 m/s.
Soil Respiration Phenology Improves Modeled Phase of Terrestrial net Ecosystem Exchange in Northern Hemisphere
Authors: Endsley K. Arthur , Kimball John S. , Reichle Rolf H. 
Published: February 2022

AbstractIn the northern hemisphere, terrestrial ecosystems transition from net sources of CO2 to the atmosphere in winter to net ecosystem carbon sinks during spring. The timing (or phase) of this transition, determined by the balance between ecosystem respiration (RECO) and primary production, is key to estimating the amplitude of the terrestrial carbon sink. We diagnose an apparent phase bias in the RECO and net ecosystem exchange (NEE) seasonal cycles estimated by the terrestrial carbon flux (TCF) model framework and investigate its link to soil respiration mechanisms. Satellite observations of vegetation canopy conditions, surface meteorology, and soil moisture from the NASA SMAP Level 4 Soil Moisture product are used to model a daily carbon budget for a global network of eddy covariance flux towers. Proposed modifications to TCF include: the inhibition of foliar respiration in the light (the Kok effect); a seasonally varying litterfall phenology; an O2 diffusion limitation on heterotrophic respiration (RH); and a vertically resolved soil decomposition model. We find that RECO phase bias can result from bias in RECO magnitude and that mechanisms which reduce northern spring RECO, like substrate and O2 diffusion limitations, can mitigate the phase bias. A vertically resolved soil decomposition model mitigates this bias by temporally segmenting and lagging RH. Applying these model enhancements at continuous soil respiration (COSORE) sites verifies their improvement of RECO and NEE skill compared to in situ observations (up to ΔRMSE = −0.76 g C m−2 d−1). Ultimately, these mechanisms can improve prior estimates of NEE for atmospheric inversion studies.
Lack of germline transmission in male mice following a single intravenous administration of AAV5-hFVIII-SQ gene therapy
Authors: Fonck Carlos , Su Cheng , Arens Jeremy , Koziol Elli , Srimani Jaydeep , Henshaw Joshua , Van Tuyl Andrea , Chandra Sundeep , Vettermann Christian , O’Neill Charles A. 
Published: February 2022

AbstractValoctocogene roxaparvovec (AAV5-hFVIII-SQ) is an adeno-associated virus serotype five gene therapy under investigation for the treatment of hemophilia A. Herein, we assessed the potential for germline transmission of AAV5-hFVIII-SQ in mice. Male B6.129S6-Rag2tm1Fwa N12 mice received a single intravenous dose of vehicle or 6 × 1013 vg/kg AAV5-hFVIII-SQ. Vehicle and AAV5-hFVIII-SQ-treated mice were mated with naïve females 4 days after dosing, when the concentration of vector genomes was expected to be at its peak in semen, and 37 days after dosing, when a full spermatogenesis cycle was estimated to be complete. Quantitative PCR was used to evaluate the presence of transgene DNA in liver and testes from F0 males dosed with AAV5-hFVIII-SQ and liver tissue of F1 offspring. Transgene DNA was detected in liver and testes of all F0 males dosed with AAV5-hFVIII-SQ, confirming successful transduction. Importantly, no transgene DNA was detected in any tested F1 offspring derived from F0 males dosed with AAV5-hFVIII-SQ. Using a novel 2-stage statistical model that takes into account the number of males dosed with AAV5-hFVIII-SQ and the number of offspring sired by these males, we estimate that the risk of germline transmission is <5% with a 99.2% confidence level.
Reconstituting the complete biosynthesis of D-lysergic acid in yeast
Authors: Wong Garrett , Lim Li Rong , Tan Yong Quan , Go Maybelle Kho , Bell David J. , Freemont Paul S. , Yew Wen Shan 
Published: February 2022

AbstractThe ergot alkaloids are a class of natural products known for their pharmacologically privileged molecular structure that are used in the treatment of neurological ailments, such as Parkinsonism and dementia. Their synthesis via chemical and biological routes are therefore of industrial relevance, but suffer from several challenges. Current chemical synthesis methods involve long, multi-step reactions with harsh conditions and are not enantioselective; biological methods utilizing ergot fungi, produce an assortment of products that complicate product recovery, and are susceptible to strain degradation. Reconstituting the ergot alkaloid pathway in a strain strongly amenable for liquid fermentation, could potentially resolve these issues. In this work, we report the production of the main ergoline therapeutic precursor, D-lysergic acid, to a titre of 1.7 mg L−1 in a 1 L bioreactor. Our work demonstrates the proof-of-concept for the biological production of ergoline-derived compounds from sugar in an engineered yeast chassis.
Coat proteins of necroviruses target 14-3-3a to subvert MAPKKKα-mediated antiviral immunity in plants
Authors: Gao Zongyu , Zhang Dingliang , Wang Xiaoling , Zhang Xin , Wen Zhiyan , Zhang Qianshen , Li Dawei , Dinesh-Kumar Savithramma P. , Zhang Yongliang 
Published: February 2022

AbstractMitogen-activated protein kinase (MAPK) cascades play an important role in innate immunity against various pathogens in plants and animals. However, we know very little about the importance of MAPK cascades in plant defense against viral pathogens. Here, we used a positive-strand RNA necrovirus, beet black scorch virus (BBSV), as a model to investigate the relationship between MAPK signaling and virus infection. Our findings showed that BBSV infection activates MAPK signaling, whereas viral coat protein (CP) counteracts MAPKKKα-mediated antiviral defense. CP does not directly target MAPKKKα, instead it competitively interferes with the binding of 14-3-3a to MAPKKKα in a dose-dependent manner. This results in the instability of MAPKKKα and subversion of MAPKKKα-mediated antiviral defense. Considering the conservation of 14-3-3-binding sites in the CPs of diverse plant viruses, we provide evidence that 14-3-3-MAPKKKα defense signaling module is a target of viral effectors in the ongoing arms race of defense and viral counter-defense.