bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying anthropogenic and natural causes of wildfires by maximum entropy method-based ignition susceptibility distribution models
Authors: Sari Fatih 
Published: June 2022

AbstractTurkey has a high potential for wildfires along its Mediterranean coast because of its dense forest cover and mild climate. An average of 250 wildfires occurs every year with more than 10,000 hectares destroyed due to natural and human-related causes. The study area is sensitive to fires caused by lightning, stubble burning, discarded cigarette butts, electric arcing from power lines, deliberate fire setting, and traffic accidents. However, 52% of causes could not be identified due to intense wildfires occurring at the same time and insufficient equipment and personnel. Since wildfires destroy forest cover, ecosystems, biodiversity, and habitats, they should be spatially evaluated by separating them according to their causes, considering environmental, climatic, topographic and forest structure variables that trigger wildfires. In this study, wildfires caused by lightning, the burning of agriculture stubble, discarded cigarette butts and power lines were investigated in the provinces of Aydın, Muğla and Antalya, where 22% of Turkey’s wildfires occurred. The MaxEnt method was used to determine the spatial distribution of wildfires to identify risk zones for each cause. Wildfires were used as the species distribution and the probability of their occurrence estimated. Additionally, since the causes of many wildfires are unknown, determining the causes is important for fire prediction and prevention. The highest wildfire occurrence risks were 9.7% for stubble burning, 30.2% for lightning, 4.5% for power lines and 16.9% by discarded cigarette butts. In total, 1,266 of the 1,714 unknown wildfire causes were identified by the analysis of the cause-based risk zones and these were updated by including cause-assigned unknown wildfire locations for verification. As a result, the Area under the ROC Curve (AUC) values were increased for susceptibility maps.
Scenario-based quantification of land-use changes and its impacts on ecosystem services: A case of Bhitarkanika mangrove area, Odisha, India
Authors: Kadaverugu Rakesh , Dhyani Shalini , Purohit Vigna , Dasgupta Rajarshi , Kumar Pankaj , Hashimoto Shizuka , Pujari Paras , Biniwale Rajesh 
Published: June 2022

Abstract
Mangrove habitats play a vital role in balancing the coastal ecosystems by providing an array of provisioning, regulating, cultural, and supporting ecosystem services. Despite several conservation measures taken to protect mangroves, they have been facing economic, socio-environmental, and climatic threats. There is a need to quantify the mangroves' ecosystem services (ES), especially in developing and under-developed nations, to fasten up the mangrove conservation. To address this issue, in the present study, we quantified the ES of the mangroves in Odisha State on the eastern coast of India. And we projected the changes in ES according to the plausible future land-use changes using scenario analysis. The plausible future scenarios (by 2030) have been generated based on the participatory surveys and key informant interviews from the stakeholders in the region. The scenarios encompass socio-economic development, infrastructural development, mangrove conservation, agriculture and aquaculture expansion, and climate change. Coastal blue carbon sequestration, sediment retention and export, and nutrient export were quantified using the InVEST (Integrated valuation of ecosystem services and trade-offs) model. Results indicate that disturbances to mangrove forests in Odisha can emit 2.16 Tg C back into the atmosphere by 2030. In an optimistic scenario, mangroves can sequester 1.55 Tg C from the atmosphere. An increase in mangrove and green cover has reduced sediment and nutrient export by a maximum of 24.9% and 7.6%, respectively. The findings will help in evidence-based decision-making about the socio-environmental systems comprising sensitive mangrove ecosystems.
Clinicopathological features of male patients with breast cancer based on a nationwide registry database in Japan
Authors: Shimomura Akihiko , Nagahashi Masayuki , Kumamaru Hiraku , Aogi Kenjiro , Asaga Sota , Hayashi Naoki , Iijima Kotaro , Kadoya Takayuki , Kojima Yasuyuki , Kubo Makoto , Miyashita Minoru , Miyata Hiroaki , Niikura Naoki , Ogo Etsuyo , Tamura Kenji , Tanakura Kenta , Yoshida Masayuki , Yamamoto Yutaka , Imoto Shigeru , Jinno Hiromitsu 
Published: June 2022

Abstract
Background
Male breast cancer (MBC) is rare; however, its incidence is increasing. There have been no large-scale reports on the clinicopathological characteristics of MBC in Japan.

Methods
We investigated patients diagnosed with breast cancer in the Japanese National Clinical Database (NCD) between January 2012 and December 2018.

Results
A total of 594,316 cases of breast cancer, including 3780 MBC (0.6%) and 590,536 female breast cancer (FBC) (99.4%), were evaluated. The median age at MBC and FBC diagnosis was 71 (45–86, 5–95%) and 60 years (39–83) (p < 0.001), respectively. MBC cases had a higher clinical stage than FBC cases: 7.4 vs. 13.3% stage 0, 37.2 vs. 44.3% stage I, 25.6 vs. 23.9% stage IIA, 8.8 vs. 8.4% stage IIB, 1.9 vs. 2.4% stage IIIA, 10.1 vs. 3.3% stage IIIB, and 1.1 vs. 1.3% stage IIIC (p < 0.001). Breast-conserving surgery was more frequent in FBC (14.6 vs. 46.7%, p = 0.02). Axillary lymph node dissection was more frequent in MBC cases (32.9 vs. 25.2%, p < 0.001). Estrogen receptor(ER)-positive disease was observed in 95.6% of MBC and 85.3% of FBC cases (p < 0.001). The HER2-positive disease rates were 9.5% and 15.7%, respectively (p < 0.001). Comorbidities were more frequent in MBC (57.3 vs. 32.8%) (p < 0.001). Chemotherapy was less common in MBC, while endocrine therapy use was similar in ER-positive MBC and FBC. Perioperative radiation therapy was performed in 14.3% and 44.3% of cases.

Conclusion
Japanese MBC had an older age of onset, were more likely to be hormone receptor-positive disease, and received less perioperative chemotherapy than FBC.
The Transcription Factor, α1ACT, Acts Through a MicroRNA Network to Regulate Neurogenesis and Cell Death During Neonatal Cerebellar Development
Authors: Wei Cenfu , Benzow Kellie , Koob Michael D. , Gomez Christopher M. , Du Xiaofei 
Published: June 2022

AbstractMicroRNAs, a class of small RNA regulators, function throughout neurodevelopment, from neural stem cell neurogenesis to neuronal maturation, synaptic formation, and plasticity. α1ACT, a transcription factor (TF), plays a critical role in neonatal cerebellar development by regulating an ensemble of genes. Of these, ChIP-seq analysis matched near 50% genes directly regulated by α1ACT. Yet, more than half the regulated transcripts lacked direct interaction with α1ACT. To investigate whether α1ACT acts through a microRNA network, we studied α1ACT-associated simultaneous miRNA:mRNA transcriptome profiles, using miRNA-seq paired with RNA-seq. Thirty-one differentially expressed miRNAs (DEMs) associated with α1ACT-regulated differentially expressed genes (DEGs) were profiled in α1ACT-overexpressing PC12 cells and were further validated in neonatal transgenic mouse cerebellum overexpressing α1ACT in a context-dependent manner. Here, we also demonstrated that α1ACT facilitates neurogenesis and development of dendritic synapses and is partially a result of the downregulation of the miR-99 cluster, miR-143, miR-23, miR-146, miR-363, and miR-484. On the other hand, the miR-181, miR-125, and miR-708 clusters were upregulated by α1ACT, which inhibit MAPK signaling and cell death pathways by targeting Ask1, Odc1, Atf4, and Nuf2 for decreased expression. MiR-181a-5p was verified as the most abundant DEM in neonatal cerebellum, which was further induced by α1ACT. Overall, under α1ACT modulation, up-/downregulated miRNA clusters with their paired target genes may form a regulatory network controlling the balance between the neuronal proliferation, differentiation, and cell death in the cerebellum to promote neonatal development. Our findings concerning the α1ACT-related miRNA/mRNA expression profiles in neonatal cerebellum may inform future investigations for cerebellar development.
Reconceptualization of eating addiction and obesity as displacement behavior and a possible treatment
Authors: Pretlow Robert , Glasner Suzette 
Published: June 2022

Abstract
Purpose
Displacement behavior is a biobehavioral mechanism that allows an animal to deal with situations that cannot readily be faced nor avoided, or that are thwarting. It may explain compulsive overeating (eating addiction). Resembling addiction, displacement behavior is irrepressible behavior that is contextually inappropriate, e.g., sleeping or feeding when threatened by a predator, or binge eating in response to a work altercation. It is thought to be due to rechanneling of overflow brain energy to another drive (e.g., feeding drive) when two drives, e.g., fight or flight, equally oppose each other. Moving the opposing drives out of equilibrium, by resolving the person’s underlying problems/stressful situations, theoretically should mitigate the displacement mechanism and addictive overeating.

Methods
We developed a mobile phone intervention targeting addictive overeating, including a displacement mechanism component. A displacement use subgroup (N = 37) ages 14–18 with obesity (mean BMI = 38.1) identified life situations they could neither face nor avoid, or that were thwarting them, and developed action plans to address each situation. Feasibility and acceptability were evaluated.

Results
Participants found the displacement component to be understandable and user-friendly. The majority (26/37–70%) used the core “Dread List” feature to input 90 individual dreaded/problem situations fueling displacement-based overeating, coupled with action plans to address each problem. Dread items related to school accounted for nearly one-half (46%: 41/90) of all dread situations reported by participants.

Conclusion
The displacement mechanism may be a useful basis for treatment of eating addiction and obesity and may provide individuals with hope that they can curb their addiction without relying on willpower to not overeat. A randomized trial evaluating the displacement intervention is planned.

Level of evidence
Level V: Opinions of respected authorities, based on descriptive studies, narrative reviews, clinical experience, or reports of expert committees.

Registration
The study was reported according to the Consolidated Standards of Reporting Trials (CONSORT) statement and was registered with ClinicalTrials.gov (NCT03500835) April 18, 2018.
The Limit Notion at Three Educational Levels in Three Countries
Authors: Viirman Olov , Vivier Laurent , Monaghan John 
Published: June 2022

AbstractThis paper documents how the limit concept is treated in high school, at a university and in teacher education in England, France and Sweden. To this end we make use of vignettes, data-grounded accounts of the situation at the three levels in the three countries. These are analysed using the Anthropological Theory of the Didactic (ATD). While university praxeologies are relatively similar across the three countries, greater differences manifest themselves in high school and teacher education. For instance, at the high school level, in France a local praxeology on the limits of sequences is taught, which is not the case in England or Sweden. Results from the analysis of limits are extrapolated to comment on implications for the teaching of calculus, and for teacher education, in the three countries. The paper also raises methodological issues in our approach.
Fostering ethical reflection on health data research through co-design: A pilot study
Authors: Sleigh Joanna , Amann Julia 
Published: June 2022

AbstractHealth research ethics training is highly variable, with some researchers receiving little to none, which is why ethical frameworks represent critical tools for ethical deliberation and guiding responsible practice. However, these documents' voluntary and abstract nature can leave health researchers seeking more operationalised guidance, such as in the form of checklists, even though this approach does not support reflection on the meaning of principles nor their implications. In search of more reflective and participatory practices in a pandemic context with distance learning, this study explored whether co-design could support engagement and reflection on ethical principles amongst early-stage health researchers. In a pilot test using the Swiss Personalized Health Network's ethical framework for Responsible Usage of Personal Data in Health Research as a case study, we engaged health researchers to design visuals of four ethical principles. In two online workshops, participants (N = 10, N = 8) completed activities such as individual reflection, collaborative ideation, sketching, prototyping, discussion, and feedback. Our analysis shows that the co-design process helped foster in-depth engagement and reflection on the meaning and relevance of the SPHN ethical principles. Participants reported enjoying the experience, and most felt that visuals could motivate engagement with ethical frameworks. This study demonstrates the feasibility of a participatory, design-oriented approach to promote engagement with research ethics among early-career health researchers and highlights key challenges and lessons learned. In doing so, it lays the foundation for future research to investigate the impact of design-oriented, participatory learning to foster reflection and deliberation in ethics education.
Comparison of Cardiovascular Parameters and Internal Training Load of Different 1-h Training Sessions in Non-elite CrossFit® Athletes
Authors: Meier Nicole , Sietmann Danien , Schmidt Annette 
Published: June 2022

Abstract
Purpose
The fact that CrossFit® is the best-known and rapidly growing concept for high-intensity interval training (HIIT) and high-intensity functional training (HIFT) results in a continuous increase of athletes performing CrossFit®. In the more than 15,000 CrossFit® Affiliates worldwide, the training concept is usually offered in 1-h training sessions containing the CrossFit®-related workout of the day (WOD), as well as a general warm-up, movement demonstrations, and skill training. Here, we report how physiological parameters measured by heart rate (HR) values vary during four different 1-h CrossFit® training sessions of non-elite athletes (n = 27) in a local affiliated training center and what influencing factors may exist.

Methods
The duration of the 1-h training sessions were divided into a warm-up part (WU-part), a skill development part combined with strength exercises (A-part), followed by the WOD part (B-part).

Results
Analysis of HR values shows high training intensity (≥ 91% HRmax) not throughout the duration of each training session, only during B-part. The mean HR values in B-part differ significantly compared to the remaining training parts (P < 0.001) for all four training sessions. Comparison of different CrossFit® experience levels revealed no significant difference in acute physiological demands and training load between beginner and experienced CrossFit® athletes.

Conclusion
Our results may suggest that practicing CrossFit® in 1-h training sessions combined anaerobic and aerobic exercise intensities, with the training concept allows beginners and experienced athletes to be trained with the same cardiovascular responses and training intensities.
Computer-Assisted Surgery Enables Beginner Surgeons, Under Expert Guidance, to Achieve Long-Term Clinical Results not Inferior to Those of a Skilled Surgeon in Knee Arthroplasty
Authors: Larrainzar-Garijo Ricardo , Molanes-López Elisa M. , Cañones-Martín Miguel , Murillo-Vizuete David , Valencia-Santos Natalia , Garcia-Bogalo Raul , Corella-Montoya Fernando 
Published: June 2022

Abstract
Purpose
The purpose of this study is to determine whether the use of a surgical navigation system in total knee replacement (TKR) enables beginner and intermediate surgeons to achieve clinical PROM outcomes as good as those conducted by expert surgeons in the long term.

Methods
We enrolled 100 consecutive patients whose total navigated knee arthroplasty (TKA) was performed in our institution from 2008 to 2010. According to the principal surgeon's surgical experience, the patients were divided into three groups: (1) beginner surgeons, with no more than 30 previous knee replacement performances, (2) intermediate surgeons, with more than 30 but not more than 300, and (3) expert surgeons, with more than 300 knee replacements. Demographic data collected on the cohort included gender, laterality, age, and body mass index (BMI). The outcome measures assessed were Forgotten Joint Score (FJS), implant positioning, limb alignment, and prosthesis survival rate. A margin of equivalence of ± 18.5 points in the FJS scale was prespecified in terms of the minimal clinically important difference (MCID) to compare the FJS results obtained in the long period between the groups of interest.

Results
The mean follow-up was 11.10 ± 0.78, 10.86 ± 0.66, and 11.30 ± 0.74 years, respectively, for each of the groups. The long-term FJS mean score was 80.86 ± 21.88, 81.36 ± 23.87, and 90.48 ± 14.65 for each group. The statistical analysis proved noninferiority and equivalence in terms of the FJS results reported in the long term by patients in Groups 1 or 2 compared to those in Group 3. More specifically, it has been proved that the mean difference between groups is within the interval of equivalence defined in terms of the MCID. The overall prostheses survival rate was 93.7%.

Conclusion
Navigated assisted TKA, under expert guidance, can be as effective when performed by beginner or intermediate surgeons as performed by senior surgeons regarding the accuracy of implant positioning, limb alignment, and long-term clinical outcome.
Replies to critics
Authors: Rosenkranz Sven 
Published: June 2022

AbstractResponding to the critical comments by the symposiasts Julien Dutant, Niccolò Rossi, Martin Smith, Daniel Waxman, and Yiwen Zhan, I further elaborate, refine, and defend the account of epistemic justification I advanced in my book Justification as Ignorance (Oxford: Oxford University Press, 2021). Central issues tackled here include logical omniscience and non-normal epistemic logics, the luminosity of epistemic justification, methods for telling what one is in no position to know, and the relation between doxastic and propositional justification.
Petticoat Power? Mary Astell's Appropriation of Heroic Virtue for Women
Authors: BROWN DEBORAH J. , BROAD JACQUELINE 
Published: June 2022

AbstractSeveral recent studies devote themselves to Mary Astell's feminist theory of virtue—her ‘serious proposal to the ladies’ to help women obtain wisdom, equality, and happiness, despite the prejudices of seventeenth-century custom. But there has been little scholarship on Astell's conception of heroic virtues, those exceptional character traits that raise their bearers above the ordinary course of nature. Astell's appropriation of heroic virtue poses a number of philosophical difficulties for her feminist ethics—heroic virtues are characteristically masculine, exceptional, and individualistic, ill-suited to a community-oriented feminism aimed at ordinary women. In this paper, we seek to investigate—and then dispel—these key difficulties. Our intention is to generate a new understanding of Astell's theory of virtue as a unique and sophisticated theory that equalizes and naturalizes heroic virtue for women.
Rising from the pandemic ashes: Reflections on burnout and resiliency from the infection prevention and antimicrobial stewardship workforce
Authors: Nori Priya , Stevens Michael P. , Patel Payal K. 
Published: June 2022

Abstract
Hospital epidemiologists, infection preventionists, and antimicrobial stewards are integral to the pandemic workforce. However, regardless of pandemic surge or postsurge conditions, their workload remains high due to constant vigilance for new variants, emerging data, and evolving public health guidance. We describe the factors that have led to burnout and suggest strategies to enhance resilience.
Pandemic crisis and employee skills: how emotion regulation and improvisation limit the damaging effects of perceived pandemic threats on job performance
Authors: De Clercq Dirk , Fatima Tasneem , Jahanzeb Sadia 
Published: June 2022

AbstractThis study details the possible escalation of employees' perceptions of pandemic threats into diminished job performance, while considering a mediating role of their sense of job insecurity and a moderating role of their emotion regulation and improvisation skills. Results based on multisource, three-wave data show that employees' perceived pandemic threats compromise their work-related performance, because they believe that their job is at risk. This mediating role of perceived job insecurity is mitigated by employees' greater ability to control their emotions and come up with novel ideas on the spot. This study accordingly pinpoints employees' conviction that they may not be able to keep their jobs as a crucial mechanism by which the hardships of a global pandemic generate negative performance consequences, as well as how organizations can contain this risk by helping employees hone their pertinent personal skills.
Fibonacci-Lucas hyperbolas
Authors: Sporn Howard 
Published: June 2022

Let us define a Fibonacci-Lucas hyperbola as a hyperbola passing through an infinite number of points of the form (Fm, Ln), where the Fm are distinct Fibonacci numbers (0, 1, 1, 2, 3, 5, 8, 13, 21,…, where F0 = 0), and the Ln are distinct Lucas numbers (2, 1, 3, 4, 7, 11, 18, 29,…,. where L0 = 2). The simplest examples are 5x2 - y2 = 4, which contains the points (Fk, Lk) with odd subscripts, e.g. (1, 1), (2, 4), (5, 11), and 5x2 - y2 = -4, which contains the points with even subscripts, e.g. (0, 2), (1, 3), (3, 7); (see [1, 2]). These follow immediately from the identity
(1)
$$L_n^2 - 5F_n^2 = 4{( - 1)^n}.$$

Our goal is to find more of these Fibonacci-Lucas hyperbolas.