bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progressing nemaline myopathy in a patient repeatedly operated on the spine: clinical case and literature review
Authors: Prudnikova O. G. , Kotelnikov A. O. , Migalkin N. S. , Filimonova G. N. 
Published: March 2022

Objective. To present a clinical case of a patient with spinal deformity associated with myopathy, which was initially undiagnosed and assessed as secondary myopathy after performed spinal surgeries.Material and Methods. Study design: clinical observation and review of the literature. A 51-year-old female patient has been repeatedly operated on for scoliotic deformity of the spine with progressing neurological disorders. Clinical and complex radiological assessment (spinal telemetry in sitting position, CT, MRI) of the pathology was performed. In connection with the atypical course of the disease, a pathohistological study of muscle tissue fragments was performed with their fixation in a solution of 10 % neutral formalin. After histological processing, the fragments were embedded in paraffin and stained with hematoxylin-eosin by the Masson trichromic method and by the PTAH method. The preparations were examined using the Pannoramic MIDI II BF hardware and software complex to obtain digital images using the Whole slide imaging technology in the Single layer and Extended focus modes and an AxioScope.A1 stereomicroscope with a digital camera.Results. Two patterns of distribution of nemaline rods of various density and configuration stained dark blue (by PTAH) were identified in sarcoplasm of parts of muscular tissues: diffusely throughout the myocyte and forming clusters of various sizes in transverse sections, and as filamentous structures – in longitudinal ones. Extensive fields of fatty degeneration, transformation of fibers into lipocytes, contracturely changed fibers, pictures of myophaga and areas of fibrosis of the interstitial space associated with residual myocytes were noted. Intramuscular nervous conductors were subjected to complete involution, singular nervous fibers were deformed, internal space was fibrotic. Neuromuscular spindles had unusually increased connective tissue capsule filled with lipocytes. Arterial vessels had fibrosis of t. adventicia and t. media, narrowed or obliterated lumen, and venous vessels were thin-walled and tortuous, which causes their permeability and can cause hemorrhage. The revealed changes in myocytes with the presence of nemaline rods are characteristic of primary nemaline myopathy.Conclusion. The atypicality of clinical manifestations, primarily of the neurological status in scoliosis, requires excluding neuromuscular disease by conducting a histopathological examination of the surgical material.
Efficiency of various options for surgical treatment and prevention of proximal junctional kyphosis in patients with lumbar spine deformities and concomitant osteoporosis
Authors: Basankin I. V. , Ptashnikov D. A. , Masevnin S. V. , Afaunov A. A. , Giulzatyan A. A. , Takhmazyan K. K. 
Published: March 2022

Objective. To conduct a comparative analysis of the effectiveness of various options for the prevention of proximal junctional kyphosis (PJK) in the surgical treatment of adult patients with deformities of the lumbar spine, including taking into account the degree of correction of the lumbar lordosis.Material and Methods. The results of instrumental fixation of the spine performed in 140 adult patients with severe frontal spinal deformity and/or sagittal imbalance corresponding to types III and IV according to Berjano and Lamartina were studied. The patients were divided into 4 clinical groups depending on the methods of surgical treatment: in 36 cases, correction of lumbar lordosis of no more than 30° was performed without the use of PJK prevention methods (Group I); in 24 – the same correction was supplemented with laminar fixation of the vertebra above the fusion zone (Group II); 20 patients underwent complete restoration of the sagittal and frontal balance with prophylactic vertebroplasty of the superjacent vertebra above the zone of instrumental fixation (Group III); and in 60 – the same intervention was performed without the use of the PJK prevention methods (Group IV).Results. Statistically significant differences in lumbar lordosis, difference in the pelvic angle and lumbar lordosis, and displacement of the sagittal vertical axis were found between the pairs of groups I and II, and III and IV. Postoperative values of the index of the proximal junctional angle (PJA) in patients of Group II differed significantly from the corresponding indicators of other groups. A statistically significant increase in the PJA after surgery was found in patients of groups III and IV. There was a statistically significant decrease in PJK cases in Group II in comparison with other groups (p = 0.001), as well as more pronounced trend to decrease in pain intensity and ODI score. Laminar fixation of the superjacent vertebra leads to a decrease in local kyphosis over the area of instrumental fixation and reduces the load on the ventral parts of the vertebra. Prophylactic vertebroplasty (Group III) provides better results compared to a comparable cohort (Group IV).Conclusion. Partial correction of lumbar lordosis (no more than 30°) and preventive laminar fixation of the superjacent vertebra showed significantly better clinical results (by more than 50 %; p = 0.001) compared with the other three clinical groups in terms of reducing the level of pain and improving the quality of life, as well as of decrease in number of cases of PJK development – by 16–28 % (p = 0.001).
Economic Analysis Methodologies Applied in Merger Investigations in the EU and China: Comparative Case Studies
Authors: Lyu Shuping , Buts Caroline , Jegers Marc 
Published: March 2022

Abstract
Understanding the application of economic analysis methods in merger reviews across various jurisdictions can benefit antitrust authorities when reviewing cases and aid the legal and economic teams that work with merging parties in better anticipating concerns and outcomes. The comparative studies on economic analysis methods applied in merger cases have mainly been focused on China/the US and the EU/US. The objective of this study is to explore how the EU and China apply economic analysis methods to merger control enforcement for the same concentrations, by means of a comparative case study. Two research questions are addressed: (i) What are the economic analysis methods employed by Chinese antitrust authorities when investigating merger cases and how are they used? (ii) What similarities and differences exist between the antitrust authorities in the EU and China in applying economic analysis methods during merger case reviews?
Nachder Krise istvorder Krise istinder Krise …
Authors: Weber Lena 
Published: March 2022

ZusammenfassungDie „Care-Krise“ war schon längst vor der „Corona-Krise“ in den Sozialwissenschaften diagnostiziert worden. Während der Corona-Krise treten die strukturellen Widersprüche der Care-Krise – einerseits gestiegener Bedarf an Care-Arbeit und andererseits Fachkräftemangel in den Care-Berufen – noch deutlicher hervor und verschärfen die Arbeitsbedingungen in der formalen Pflegearbeit, wovon Frauen ungleich stärker betroffen sind. Der vorliegende Beitrag untersucht anhand einer qualitativen Interviewstudie die alltäglichen und biografischen Arbeitsarrangements von Eltern, die in der Pflege während der Corona-Pandemie erwerbstätig sind. Die Ergebnisse zur geschlechtlichen Arbeitsteilung geben Aufschluss darüber, inwieweit ein Ausbau der Kinderbetreuungsangebote zur Gleichstellung der Geschlechter und zugleich zu einer nachhaltigen Krisenprävention und einem leistungsfähigeren Gesundheits- und Pflegesystem beitragen kann. Das geschlechtliche Arbeitsarrangement des Typus Quasi-Single-Mum zeigt, dass gesellschaftliches Mutterbild und gestiegene Anforderungen an systemrelevante Arbeitskräfte widersprüchlich zueinander sind und auf der Subjektebene zu inneren Care-Konflikten der überwiegend weiblichen Pflegekräfte führen.
Verfestigte Klassenungleichheiten
Authors: Niehoff Steffen , Holst Hajo , Fessler Agnes 
Published: March 2022

Zusammenfassung
Der Beitrag beschäftigt sich aus einer klassenanalytischen Perspektive mit der arbeitsweltlichen Dynamik der Corona-Pandemie. Auf der Basis eines Mixed-Methods-Designs, eines thematisch breiten arbeitssoziologischen Zugangs und von zwei Erhebungswellen des Arbeitswelt-Monitors „Arbeiten in der Corona-Krise“ werden die Pandemieeffekte im April/Mai 2020 und im April/ Mai 2021 miteinander verglichen. Quantitativ zeigt sich eine bemerkenswerte Kontinuität in der Risiko- und Lastenverteilung. Die beiden „harten Lockdowns“ unterscheiden sich kaum in den absoluten Betroffenheiten mit subjektiven Infektionsrisiken, wirtschaftlichen Lasten und verschlechterten Arbeitsbedingungen sowie im Zugang zum mobilen Arbeiten – und damit auch nicht in den vertikalen und horizontalen Klassenungleichheiten, die sich aus dem Zusammenspiel der Einzeleffekte ergeben. Zugleich deuten die qualitativen Interviews darauf hin, dass sich im Pandemieverlauf die Wahrnehmung der gesellschaftlichen Risiko- und Lastenverteilung verschiebt. In den stark betroffenen unteren Klassen bildet sich nämlich ein Spannungsverhältnis zwischen dem Stolz auf die eigenen Beiträge zur Pandemiebewältigung und den verfestigten Klassenungleichheiten in den Arbeitsfolgen heraus. Letztere werden zunehmend als Missachtung der eigenen Leistungen und als Angriff auf die menschliche Würde erlebt.
Die Coronapandemie: Gesundheitliche Ungleichheit und betriebliches Krisenmanagement
Authors: Becke Guido , Busse Britta , Zenz Cora , Pöser Stephanie , Mümken Sarah , Schicktanz Christel , Gerdau-Heitmann Cornelia 
Published: March 2022

Zusammenfassung
Auch in der Coronakrise korrespondiert ein niedriger sozioökonomischer Status (z.B. niedrige Bildung, niedriger beruflicher Status, niedrige Löhne) von Erwerbstätigen mit ungleich schlechteren Gesundheitschancen und größeren Krankheitsrisiken. Überdies sind verschiedene Tätigkeitsgruppen (mit jeweils spezifischen Qualifikationen und Status) unterschiedlichen Gesundheitsrisiken ausgesetzt, generell und im Besonderen, während eine hoch ansteckende Virusinfektion grassiert. Das Infektionsrisiko unterscheidet sich zwischen Berufsgruppen, die Interaktionsarbeit in Kopräsenz ausüben, und solchen, die sie primär technisch vermittelt verrichten. Die wegen der Covid-19-Pandemie von Betrieben zu treffenden Infektionsschutzmaßnahmen haben nicht-intendierte Folgen für die Arbeitsqualität, die abhängig vom Tätigkeitsfeld unterschiedlich ausfallen. Der vorliegende Beitrag analysiert vergleichend das Krisenmanagement und seine gesundheitlichen Herausforderungen bei Unternehmen der sozialen Dienste (Pflege, Hauswirtschaft) und der IT-Services sowie deren Auswirkungen auf die Beschäftigten und ihre Arbeitsqualität. Es wird anhand von Betriebsfallstudien verdeutlicht, dass das betriebliche Krisenmanagement einerseits gesundheitliche Ungleichheit zu begrenzen vermag, andererseits aber auch neue Arbeitsbelastungen hervorbringen kann, die Gesundheitschancen von Beschäftigten verschlechtern können.
Orthogonal gap-enhanced Raman tags for interference-free and ultrastable surface-enhanced Raman scattering
Authors: Li Jin , Liu Fugang , He Chang , Shen Feng , Ye Jian 
Published: March 2022

Abstract
Spectral interference from backgrounds is not negligible for surface-enhanced Raman scattering (SERS) tags and often influences the accuracy and reliability of SERS applications. We report the design and synthesis of orthogonal gap-enhanced Raman tags (O-GERTs) by embedding alkyne and deuterium-based reporters in the interior metallic nanogaps of core–shell nanoparticles and explore their signal orthogonality as optical probes against different backgrounds from common substrates and media (e.g., glass and polymer) to related targets (e.g., bacteria, cancer cells, and tissues). Proof-of-concept experiments show that the O-GERT signals in the fingerprint region (200–1800 cm−1) are likely interfered by various backgrounds, leading to difficulty of accurate quantification, while the silent-region (1800–2800 cm−1) signals are completely interference-free. Moreover, O-GERTs show much higher photo and biological stability compared to conventional SERS tags. This work not only demonstrates O-GERTs as universal optical tags for accurate and reliable detection onto various substrates and in complex media, but also opens new opportunities in a variety of frontier applications, such as three-dimensional data storage and security labeling.
A comprehensive review of the application of DEM in the investigation of batch solid mixers
Authors: Jadidi Behrooz , Ebrahimi Mohammadreza , Ein-Mozaffari Farhad , Lohi Ali 
Published: March 2022

Abstract
Powder mixing is a vital operation in a wide range of industries, such as food, pharmaceutical, and cosmetics. Despite the common use of mixing systems in various industries, often due to the complex nature of mixing systems, the effects of operating and design parameters on the mixers’ performance and final blend are not fully known, and therefore optimal parameters are selected through experience or trial and error. Experimental and numerical techniques have been widely used to analyze mixing systems and to gain a detailed understanding of mixing processes. The limitations associated with experimental techniques, however, have made discrete element method (DEM) a valuable complementary tool to obtain comprehensive particle level information about mixing systems. In the present study, the fundamentals of solid-solid mixing, segregation, and characteristics of different types of batch solid mixers are briefly reviewed. Previously published papers related to the application of DEM in studying mixing quality and assessing the influence of operating and design parameters on the mixing performance of various batch mixing systems are summarized in detail. The challenges with regards to the DEM simulation of mixing systems, the available solutions to address those challenges and our recommendations for future simulations of solid mixing are also presented and discussed.
Trends and Resource Utilization for Neonatal Jaundice Hospitalizations in the United States
Authors: Bhatt Parth , Umscheid Jacob , Ayensu Marian , Parmar Narendrasinh , Vasudeva Rhythm , Donda Keyur , Doshi Harshit , Dapaah-Siakwan Fredrick 
Published: March 2022

OBJECTIVES
To evaluate the trends in hospitalization for neonatal jaundice and its management with phototherapy and exchange transfusion in the United States from 2006 through 2016.

METHODS
Repeated, cross-sectional analysis of the 2006 to 2016 editions of the Kids’ Inpatient Database. All neonatal hospitalizations with an International Classification of Diseases, 9th or 10th Revision, Clinical Modification code for jaundice and admitted at age ≤28 days were included. The outcome measures were changes in the diagnosis of jaundice (expressed as a proportion) and its management over the years.

RESULTS
Among 16 094 653 neonatal hospitalizations from 2006 to 2016, 20.5% were diagnosed with jaundice. While the incidence of jaundice remained stable over the years, 20.9% to 20.5% (P = .1), the proportion with jaundice who received phototherapy increased from 22.5% to 27.0% (P &lt; .0001) between 2006 and 2016. There was no significant change in the exchange transfusion rate per year among neonatal hospitalizations with jaundice.

CONCLUSIONS
While the proportion of newborns with jaundice remained stable between 2006 and 2016, the use of phototherapy significantly increased with no significant change in exchange transfusion rate. The impact of these changes on the prevention of acute bilirubin encephalopathy needs further examination in future studies.
PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK BERBASIS CONTEXTUAL TEACHING AND LEARNING PADA MATERI HIMPUNAN KELAS VII SMPN 2 KUBUNG
Authors: Yulia Yulia , Gusniarti Gusniarti 
Published: March 2022

One of the problems in the world of education was the limited teaching materials that can help students enrich their experience, build students 'knowledge and support students' thinking skills to construct their own understanding in solving mathematical problems. One way that can be done to complement the shortcomings of teaching materials is to design an LKPD. LKPD is made using the CTL approach. Based on this, a CTL-based student worksheet (LKPD) was developed on set material for class VII students. This study aims to 1) produce CTL based LKPD that meets valid criteria 2) produce CTL based LKPD that meets practical criteria and 3) produces CTL based LKPD that meets the effective criteria. This is a development research with 4-D models. consists of four stages of development that is define, design, develop and disseminate. This research is only up to the stage of define, design and develop. Define’s stage consists of : a) front end analysis b) student analysis c) concept analysis d) task analysis. Design’s stage consists of : a) LKPD design b) instrument design and validation of instrument penilain module. Develop’s stage consists of : a) the stage of validity b) the stage of practicability an c) the stage of effectiveness. The results of this study indicate that based on the validator's assessment, The developed LKPD meets very valid criteria with an average of 89,14%. Based on the results of filling the practical questionnaire for educators, practical questionnaire for students and interviews with students showed that LKPD which was developed very practically was used in the mathematics learning of set material with an average of 88,20% by educators and 84,20% by students. Based on the results of the analysis of learning outcomes obtained the average value of the pre test is 59,9655 and the post test average value was 79,3793, then carried out the hypothesis with the t-test. From the calculation results obtained 5,0493 and thus with a confidence level of 95%. This shows that the hypothesis is accepted, meaning that the mathematical connection ability of students after using LKPD is better than the students’ mathematical connection ability before using LKPD so that it can be concluded that CTL based LKPD is effectively used
MANAJEMEN PEMBIAYAAN PENDIDIKAN UNTUK MENDUKUNG KEBIJAKAN KEMANDIRIAN EKONOMI PONDOK PESANTREN DI KABUPATEN ACEH TENGGARA
Authors: Prasetyo Muhammad Anggung Manumanoso 
Published: March 2022

The subject of this research is how to manage pesantren in Southeast Aceh in the aspect of economic independence, that relates to the problem of financial management in pesantren. From 36 pesantren, only 6 of them are accredited A, one of the assessment indicators is economic aspect, it means the rest are considered not sufficiently financially independent. If we/YOU see the data that is processed is qualitative using field research. The data obtained from the managers of pesantren in Southeast Aceh. The method of data collection was done through observation, interview, and documentation techniques. The study uses observation guides, interview guidelines and data documentation as research instruments. Data processing and analysis technique were carried out through three stages; data reduction, data presentation and data verification. At the implementation level, generally the management of pesantren has held business units from various existing sources / potentials, in fact the implementation has not been running as it should. The study also found that there is a relationship between quality and accessibility on the one hand, and the composition of income and expenditure at the pesantren level on the other hand. Strategic advice for the development of financial management in pesantren in Southeast Aceh as well as research findings, including (1) the presence of a financial manager or someone who has financial competence; (2) having a development plan as a form of achieving targets; (3) forming business units as a form of independence; and finally (4) team cohesiveness.
HUBUNGAN KEPEMIMPINAN DENGAN LEMBAGA PENDIDIKAN
Authors: Nabila Fanisa Syifa , Husna Inul , Makrifatullah Nuzul Habdi 
Published: March 2022

Kepemimpinan dipahami sebagai segala upaya bersama untuk menggerakan semua sumber dan alat (resources) yang tersedia dalam suatu organisasi. Resources tersebut dapat digolongkan menjadi dua bagian besar, yaitu; human resource dan non human resources. Dalam lembaga pendidikan, salah satu unit organisasi juga terdiri dari berbagai unsur atau sumber, dan manusia merupakan unsur terpenting. Untuk itu, dapat dikatakan bahwa sukses tidaknya suatu organisasi untuk mencapai tujuan yang telah ditetapkan sangat tergantung pada kemampuan pemimpin untuk menumbuhkan iklim kerjasama dengan mudah dan dapat menggerakan sumber daya yang ada sehingga dapat mendayagunakan dan dapat berjalan secara efektif dan efisien. Penelitian ini bertujuan untuk mengetahui hubungan kepemimpinan, lembaga pendidikan, serta urgensi kepemimpinan dengan lembaga pendidikan serta seperti apa kepemimpinan yang visioner. Penelitian ini menggunakan metode kualitatif dengan pendekatan studi pustaka (library research) dengan mengumpumpulkan berbagai referensi. Secara umum kepemimpinan dapat dipahami sebagai pemimpin yang mampu mengarahkan, membina atau mengatur, menuntun dan juga menunjukkan ataupun mempengaruhi. Serta lembaga pendidikan adalah suatu wadah yang berguna untuk membina manusia, membawa kearah masa depan yang lebih baik. Kepemimpinan dalam lembaga pendidikan dapat disebut sebagai seseorang yang memegang otoritas yang menentukan perkembangan lembaga pendidikan. Sebagai pemimpin pendidikan yang profesional seorang pemeimpin dituntut mampu melakukan perubahan yang bersifat pengembangan dan penyempurnaan.
Comparative assessment of cardiovascular risk in European and Korean ethnic groups in the Russian population using the SCORE and SCORE2
Authors: Bogdanov D. Yu. , Nevzorova V. A. , Shestopalov E. Yu. 
Published: March 2022

Aim. To carry out a comparative assessment of cardiovascular risk (CVR) in people aged 40-49 years of European and Korean ethnicity with a single residence area using the Systematic Coronary Risk Evaluation (SCORE) and SCORE2 scales.Material and methods. We examined 397 and 50 apparently healthy individuals of the European (EEG) and Korean (KEG) ethnic groups, respectively, who were evaluated for CVR according to the SCORE and SCORE2 charts.Results. According to the SCORE system, the median CVR in the EEG was 0 [0-0] vs 0 [0-1]% in the KEG (p<0,001), while from a clinical point of view, the groups did not differ from each other. The SCORE2 system demonstrated more significant clinical results as follows: the median risk in EEG individuals was 5 [3-8]%, which corresponds to a high CVR for this age group, and 8 [4-11]% in KEG individuals, which corresponds to a very high CVR (p=0,011). CVR assessment in apparently healthy individuals is decisive in considering the preventive measures. According to the SCORE system, 97,5% and 96% of apparently healthy EEG and KEG individuals, respectively, are classified as low and moderate risk. High and very high risk when using this system was determined in 2,5 and 4% among Europeans and Koreans, respectively. However, using the SCORE2 system, only 10,3% of Europeans were classified as low/ moderate risk, and among ethnic Koreans — 8%. At the same time, the category of high and very high risk was designated, respectively, for 63,7 and 25,9% in the EEG and 40 and 52% in the KEG, respectively. It has been established that according to the SCORE2 system, more than half of Koreans aged 40-49 already have a very high CVR, which significantly distinguishes this group from the European population.Conclusion. The SCORE2 system has a more differentiated approach in determining individual CVR. The SCORE2 assessment of non-high density lipoprotein cholesterol levels makes it more personalized for use in different ethnic populations.