bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conceptualising, designing and drafting a monthly multi‐family therapy programme and manual for adolescents with anorexia nervosa
Authors: Minier Lisa , Carrot Benjamin , Cook‐Darzens Solange , Criquillion‐Doublet Sophie , Boyer France , Barton‐Clegg Vesper , Simic Mima , Voulgari Stamatoula , Godart Nathalie , Duclos Jeanne ,   the THERAFAMBEST group
Published: May 2022

AbstractThe written transmission of therapists' expertise in manuals is an important issue which is highlighted in the literature. Manuals are essential for research, training and therapeutic guidance. However, the conceptualisation, design and drafting of therapy manuals have received little attention. Our team conceptualised and designed a 10‐monthly session multi‐family therapy programme for adolescents suffering from anorexia nervosa. This paper presents the methodology used to evolve from training and theoretical models to designing a programme and drafting the accompanying manual. We then describe how our team reached a consensus regarding the role to be attributed to food‐related symptoms in the programme. These arduous tasks were rewarded by fruitful discussions among team members, which led to a shared theory of treatment. The methodology presented here is drawn from both the experience of specialised teams and from that of families in providing care to adolescents with anorexia nervosa.
Maternal race and pre‐eclampsia: Cohort study and systematic review with meta‐analysis
Authors: Arechvo Anastasjja , Voicu Diana , Gil María M. , Syngelaki Argyro , Akolekar Ranjit , Nicolaides Kypros H. 
Published: May 2022

AbstractObjectivesTo examine the association between race and pre‐eclampsia and gestational hypertension after adjustment for factors in maternal characteristics and medical history in a screening study from the Fetal Medicine Foundation (FMF) in England, and to perform a systematic review and meta‐analysis of studies on pre‐eclampsia.DesignProspective observational study and systematic review with meta‐analysis.SettingTwo UK maternity hospitals.PopulationA total of 168 966 women with singleton pregnancies attending for routine ultrasound examination at 11–13 weeks of gestation without major abnormalities delivering at 24 weeks or more of gestation.MethodsRegression analysis examined the association between race and pre‐eclampsia or gestational hypertension in the FMF data. Literature search to December 2021 was carried out to identify peer‐reviewed publications on race and pre‐eclampsia.Main outcome measureRelative risk of pre‐eclampsia and gestational hypertension in women of black, South Asian and East Asian race by comparison to white women.ResultsIn black women, the respective risks of total‐pre‐eclampsia and preterm‐pre‐eclampsia were 2‐fold and 2.5‐fold higher, respectively, and risk of gestational hypertension was 25% higher; in South Asian women there was a 1.5‐fold higher risk of preterm pre‐eclampsia but not of total‐pre‐eclampsia and in East Asian women there was no statistically significant difference in risk of hypertensive disorders. The literature search identified 19 studies that provided data on several million pregnancies, but 17 were at moderate or high‐risk of bias and only three provided risks adjusted for some maternal characteristics; consequently, these studies did not provide accurate contributions on different racial groups to the prediction of pre‐eclampsia.ConclusionIn women of black and South Asian origin the risk of pre‐eclampsia, after adjustment for confounders, is higher than in white women.
Idiopathic intracranial hypertension: Evaluation of births and fertility through the Hospital Episode Statistics dataset
Authors: Thaller Mark , Mytton Jemma , Wakerley Benjamin R. , Mollan Susan P. , Sinclair Alexandra J. 
Published: May 2022

AbstractObjectiveIdiopathic intracranial hypertension (IIH) predominantly affects women of reproductive age with obesity, and these women have a distinct profile of hyperandrogenism and insulin resistance. Polycystic ovary syndrome (PCOS) has an established adverse fertility phenotype that typically affects obese women. As IIH may impact reproductive health, we sought to evaluate fertility, gestational complications and pregnancy outcome in IIH.DesignProspective cohort study from English Hospital Episode Statistics dataset.SettingEnglish hospitals, UK.PopulationWomen aged 18–45 years seen in English hospitals between 1 April 2002 and 31 March 2019. Patients were required to have an IIH diagnosis and were compared with those with PCOS and general population female controls.Main outcome measuresPregnancies resulting in live births, complications of gestational diabetes and pre‐eclampsia, and method of delivery.ResultsData was collected from 17 587 IIH, 199633 PCOS and 10 947 012 women in the general population. The live birth rate, adjusted for age, was significantly lower among women with IIH (54.1%) than PCOS (67.9%), p < 0.0001 and the general population (57.7%), p < 0.0001. Pre‐eclampsia and gestational diabetes risks were higher following a diagnosis of IIH (5.3‐fold and 2.7‐fold, respectively, p < 0.0001) compared with the general population controls. Following a diagnosis of IIH, elective caesarean section rates were more than twice that of general population (odds ratio [OR] 2.4) and prior to a diagnosis of IIH (OR 2.2).ConclusionsThese data indicate there are lower age‐adjusted total pregnancy rates, increased risk of pre‐eclampsia and gestational diabetes, and a doubling of elective caesarean section rates in those with a diagnosis of IIH.
Revenue growth in not‐for‐profit organisations: The effects of interactive and diagnostic controls and organisational culture
Authors: Jiao Lu , Harrison Graeme , Chen Jinhua 
Published: May 2022

AbstractUsing survey and archival data for 180 not‐for‐profit aged care organisations, we find that interactive use of performance measurement systems positively affects the organisations’ revenue growth, while the diagnostic use negatively affects revenue growth. We also find that organisational culture, specifically attention to detail, innovation and respect for people, moderates these effects. Our findings have implications for the literature in terms of understanding the combinatorial effects of formal management control and culture on organisational performance. The findings also have practical implications for designing performance measurement systems and developing organisational cultures, to create an internal environment effective in enabling revenue growth.
Concurrent extramammary Paget's disease involving the genitalia and axilla: Case report and literature review
Authors: Zhao Chunxia , Zhang Guohong , Li Yurong , Zhang Chong , Yang Shuxia , Li Hang 
Published: May 2022

AbstractConcurrent multiple primary extramammary Paget's disease (EMPD) is rare. Herein, we present two Chinese cases of concurrent primary EMPD involving both the genitalia and the axilla, and they also had a history of other malignancy. We also summarise the cases of multiple primary EMPD previously described in literature. Careful examination of all apocrine sweat gland‐bearing sites and additional internal malignancies is recommended for patients with EMPD.
Risk factors and outcomes for patients with bleeding complications receiving extracorporeal membrane oxygenation: An analysis of the Chinese Extracorporeal Life Support Registry
Authors: Li Chenglong , Cai Tong , Xie Haixiu , Wang Liangshan , Yang Feng , Du Zhongtao , Hong Xiaoyang , Zhou Chengbing , Li Yimin , Qiu Haibo , Tong Zhaohui , Zeng Hui , Peng Zhiyong , Li Xin , Hou Xiaotong 
Published: May 2022

AbstractObjectiveBleeding is a severe complication of patients supported with extracorporeal membrane oxygenation (ECMO). This study aimed to analyze the occurrence, risk factors, and clinical outcomes of patients on ECMO with bleeding complications.MethodsECMO cases reported to the multicenter ECMO registry database of the Chinese Society of Extracorporeal Life Support (CSECLS) from January 2017 to December 2020 were enrolled. General information, ECMO indications, application, complications, and patient outcomes were collected and analyzed.ResultsA total of 6541 ECMO patients from 112 centers were enrolled. Overall, 1185 patients (18.1%) presented with one of the following bleeding complications, including 82 cases (1.3%) with severe bleeding during ECMO catheterization, 462 cases (7.1%) with bleeding at the ECMO cannulation site, 200 cases (3.5%) with bleeding at the surgical site, 180 cases (2.8%) with cerebral hemorrhage, 99 cases (1.5%) with pulmonary hemorrhage, 200 cases (3.5%) with gastrointestinal hemorrhage, 82 cases (1.3%) with ECMO withdrawal, and 118 (1.8%) deaths due to severe bleeding. Extracorporeal cardiopulmonary resuscitation (ECPR) patients had the highest incidence of bleeding complications (22.4%), followed by those on circulatory support (18.7%) and respiratory support (15.4%) (p < 0.001). Multivariate analysis showed that pediatric patients (odds ratio [OR] 1.509, p < 0.001), patients receiving renal replacement therapy (OR 1.932, p < 0.001), and patients receiving central ECMO cannulation (OR 3.023, p < 0.001) were independent risk factors for all bleeding complications, while peripheral cannulation (OR 0.712, p < 0.001) was an independent protective factor. Patients with any bleeding complication had significantly higher in‐hospital mortality than patients without (61.9% vs. 46.3%, p < 0.001).ConclusionUp to 18.1% of ECMO patients in the CSECLS registry experienced bleeding complications, which was associated with higher in‐hospital mortality, especially in patients who received ECPR, patients on circulatory support, and pediatric patients, which should arouse the attention of clinicians.
Interventions to reduce loneliness among Chinese older adults: A network meta‐analysis of randomized controlled trials and quasi‐experimental studies
Authors: Li Jia , Zhou Xiaochen , Wang Qi 
Published: May 2022

AbstractThis meta‐analytic study investigates the effectiveness of different interventions in alleviating loneliness among Chinese older adults aged 50 years and above. We searched eight English databases, four Chinese databases, and grey literature. Thirty‐four studies, including four randomized controlled trials (RCTs) and 30 quasi‐experimental studies, were eventually included in the meta‐analysis (n = 3843). Quality appraisal indicated risks of bias in the included studies. The pooled effect size was large and significant (Hedge'sg = 0.84, 95% CI [0.54, 1.15]), indicating the effectiveness of interventions in reducing loneliness. However, the effect size may be overestimated due to publication bias. Moderation analyses showed significant differences in effect sizes by study designs and regions of studies. Network meta‐analysis (NMA) indicated that hybrid and psychological interventions appeared to be advantageous over others. In addition, group‐based delivery modes can add extra benefits to the interventions. This study adds to the knowledge of the effectiveness of current interventions in reducing Chinese older people's loneliness. However, the findings need to be interpreted with caution due to the relatively low study quality, considerable heterogeneity, and publication bias. Despite the limitations, this study offers valuable insights for future research, practice, and policy‐making in reducing older people's loneliness.
Hyperspectral imaging for quantitative assessment of hepatic steatosis in human liver allografts
Authors: Wagner Tristan , Katou Shadi , Wahl Philip , Vogt Franziska , Kneifel Felicia , Morgul Haluk , Vogel Thomas , Houben Philipp , Becker Felix , Struecker Benjamin , Pascher Andreas , Radunz Sonia 
Published: May 2022

AbstractIntroductionIn liver transplantation (LT), steatosis is commonly judged to be a risk factor for graft dysfunction, and quantitative assessment of hepatic steatosis remains crucial. Liver biopsy as the gold standard for evaluation of hepatic steatosis has certain drawbacks, that is, invasiveness, and intra‐ and inter‐observer variability. A non‐invasive, quantitative modality could replace liver biopsy and eliminate these disadvantages, but has not yet been evaluated in human LT.MethodsWe performed a pilot study to evaluate the feasibility and accuracy of hyperspectral imaging (HSI) in the assessment of hepatic steatosis of human liver allografts for transplantation. Thirteen deceased donor liver allografts were included in the study. The degree of steatosis was assessed by means of conventional liver biopsy as well as HSI, performed at the end of back‐table preparation, during normothermic machine perfusion (NMP), and after reperfusion in the recipient.ResultsOrgan donors were 51 [30–83] years old, and 61.5% were male. Donor body mass index was 24.2 [16.5–38.0] kg/m2. The tissue lipid index (TLI) generated by HSI at the end of back‐table preparation correlated significantly with the histopathologically assessed degree of overall hepatic steatosis (R2 = .9085, P < .0001); this was based on a correlation of TLI and microvesicular steatosis (R2 = .8120; P < .0001). There is also a linear relationship between the histopathologically assessed degree of overall steatosis and TLI during NMP (R2 = .5646; P = .0031) as well as TLI after reperfusion (R2 = .6562; P = .0008).ConclusionHSI may safely be applied for accurate assessment of hepatic steatosis in human liver grafts. Certainly, TLI needs further assessment and validation in larger sample sizes.
International sourcing, complementary inputs, and the structure of trade agreements: Deep, shallow, narrow, and wide
Authors: Chisik Richard , Rohany Tabatabai Sara 
Published: May 2022

AbstractWe analyze Preferential Trade Agreement (PTA) formation among a subset of members of a multilateral agreement when imported inputs are complementary to one another. A shallow (focused only on border policies) multilateral agreement does not place countries on the efficiency frontier. Furthermore, no subset of countries will form a shallow PTA. Alternatively, a deep PTA that addresses behind‐the‐border policies increases each country's welfare. This result suggests that the recent proliferation of PTA formation is driven by a need for deep integration. Although these deep PTAs increase welfare over a shallow multilateral agreement the efficiency frontier can only be reached by a deep multilateral agreement that covers both border and behind‐the‐border policies. Whether a deep PTA can generate consensus approval for further multilateral‐deep integration depends on the structure of the PTA and the success of the multilateral‐shallow agreement in lowering tariffs.
Harvesters (Arachnida: Opiliones) mate more at cooler temperatures, but the effect of temperature on mating varies across years
Authors: Fowler‐Finn Kasey D. , Johnson Todd 
Published: May 2022

AbstractTemperature impacts a wide range of mating behaviors, particularly in ectothermic organisms that tend to have body temperatures similar to ambient thermal conditions. Here, we test the effects of thermal variation on precopulatory and copulatory behavior in the harvester Leiobunum politum Weed 1889, which belongs to the group commonly known as daddy longlegs. We ran single choice mating trials across temperatures commonly experienced in the field during the mating season (18–34°C) for 2 years. We tested how temperature affected the likelihood to move, attempt to mate, and successfully mate, as well as the duration of copulation. Mating was highest at low to intermediate temperatures, and the temperature at which peak mating rates occurred varied across years. The wide range of temperatures across which L. politum is found to mate reflects thermal variability in the field and the flexibility in mating behavior in this fascinating animal.
T‐cell activation and bacterial infection in skin wounds of recessive dystrophic epidermolysis bullosa patients
Authors: Alexeev Vitali , Huitema Leonie , Phillips Taylor , Cepeda Rodrigo , de los Cobos Diego , Perez Regina Isabella Matus , Salas‐Garza Mauricio , Fajardo‐Ramirez Oscar R. , Ringpfeil Franziska , Uitto Jouni , Salas‐Alanis Julio Cesar , Igoucheva Olga 
Published: May 2022

AbstractRecessive dystrophic epidermolysis bullosa (RDEB) patients develop poorly healing skin wounds that are frequently colonized with microbiota. Because T cells play an important role in clearing such pathogens, we aimed to define the status of adaptive T cell‐mediated immunity in RDEB wounds. Using a non‐invasive approach for sampling of wound‐associated constituents, we evaluated microbial contaminants in cellular fraction and exudates obtained from RDED wounds. Infectivity and intracellular trafficking of inactivated Staphylococcus aureus was accessed in RDEB keratinocytes. S. aureus and microbial antigen‐specific activation of RDEB wound‐derived T cells were investigated by fluorescence‐activated cell sorting‐based immune‐phenotyping and T‐cell functional assays. We found that RDEB wounds and epithelial cells are most frequently infected with Staphylococcus sp. and Pseudomonas sp. and that S. aureus essentially infects more RDEB keratinocytes and RDEB‐derived squamous cell carcinoma cells than keratinocytes from healthy donors. The RDEB wound‐associated T cells contain populations of CD4+ and CD8+ peripheral memory T cells that respond to soluble microbial antigens by proliferating and secreting interferon gamma (IFNγ). Moreover, CD8+ cytotoxic T lymphocytes recognize S. aureus‐infected RDEB keratinocytes and respond by producing interleukin‐2 (IL‐2) and IFNγ and degranulating and cytotoxically killing infected cells. Prolonged exposure of RDEB‐derived T cells to microbial antigens in vitro does not trigger PD‐1‐mediated T‐cell exhaustion but induces differentiation of the CD4high population into CD4highCD25+FoxP3+ regulatory T cells. Our data demonstrated that adaptive T cell‐mediated immunity could clear infected cells from wound sites, but these effects might be inhibited by PD‐1/Treg‐mediated immuno‐suppression in RDEB.
Social deficits in BTBR T+ Itpr3tf/J mice vary with ecological validity of the test
Authors: Winiarski Maciej , Kondrakiewicz Ludwika , Kondrakiewicz Kacper , Jędrzejewska‐Szmek Joanna , Turzyński Krzysztof , Knapska Ewelina , Meyza Ksenia 
Published: May 2022

AbstractTranslational value of mouse models of neuropsychiatric disorders depends heavily on the accuracy with which they replicate symptoms observed in the human population. In mouse models of autism spectrum disorder (ASD) these include, among others, social affiliation, and communication deficits as well as impairments in understanding and perception of others. Most studies addressing these issues in the BTBR T+ Itpr3tf/J mouse, an idiopathic model of ASD, were based on short dyadic interactions of often non‐familiar partners placed in a novel environment. In such stressful and variable conditions, the reproducibility of the phenotype was low. Here, we compared physical conditions and the degree of habituation of mice at the time of testing in the three chambered social affiliation task, as well as parameters used to measure social deficits and found that both the level of stress and human bias profoundly affect the results of the test. To minimize these effects, we tested social preference and network dynamics in mice group‐housed in the Eco‐HAB system. This automated recording allowed for long‐lasting monitoring of differences in social repertoire (including interest in social stimuli) in BTBR T+ Itpr3tf/J and normosocial c57BL/6J mice. With these observations we further validate the BTBR T+ Itpr3tf/J mouse as a model for ASD, but at the same time emphasize the need for more ecological testing of social behavior within all constructs of the Systems for Social Processes domain (as defined by the Research Domain Criteria framework).
Profiles of sturgeon protein prepared by two methods and the correlation between protein fractions and functional properties
Authors: Wu Chongyi , Fang Yizhou , Huang Shiwen , Shao Jiahui , Liu Jianhua , Huang Guangrong 
Published: May 2022

SummaryIn order to find the potential functional components in sturgeon protein, the protein fractions and functional properties of sturgeon proteins (SP) prepared by two methods were investigated, including pH‐shift and subcritical dimethyl ether extraction (SDEE). In the case of the former method, four different experimental conditions were followed. The SP prepared by alkali‐aided pH‐shift had the highest salt‐soluble protein content as well as the lowest water‐soluble protein content, while the highest water‐soluble protein content was observed in SDEE‐produced SP due to a higher proportion of water‐soluble protein that was retained during SDEE. Besides, the significant variations in almost all detected myofibrillar and sarcoplasmic fractions were observed across protein samples, which was mainly due to the solubility of various proteins under different preparation conditions. Moreover, the SDEE‐produced SP possessed the greatest capacities in all the emulsification, foaming and gelation, followed by alkali‐aided pH‐shift and acid‐aided pH‐shift. In addition, the correlation analysis results indicated that enolase, aldolase, PM‐2, TI, NDK, parvalbumin, actin and tropomyosin might be the primary functional components, while PM‐1, CK, MLC3, degradation products and lipids had negative effects on its functional properties. Therefore, changes of the above components might be another important reason to explain how different methods affect the quality of protein, except for the degradation of protein.
Application and challenges of 3D food printing technology in manned spaceflight: a review
Authors: Zhang Long‐zhen , Dong Hai‐sheng , Yu Yan‐bo , Liu Li‐yan , Zang Peng 
Published: May 2022

SummaryThree‐dimensional (3D) food printing is a digital food engineering method that has a remarkable application potential in long‐term manned spaceflight. Extrusion‐based 3D food printing, among the available 3D food printing techniques utilised in the food industry, is one of the most suitable printing methods for manned spaceflight. Extrusion‐based 3D food printing could suffice most of the energy and personalised nutritional requirements of astronauts during long‐term stay in space by utilising fruits, vegetables, meat products, and nutrients as printing materials. However, 3D food printing in manned spaceflight is still limited by technologies and costs such as printing materials, microgravity, post‐processability of food, and engineering transportation under the existing technical conditions. Therefore, this article reviews the 3D food printing and manned spaceflight technologies that are currently available and discusses the challenges involved in 3D food printing in manned spaceflight, thus providing a theoretical basis for future 3D food printing for space missions.
Design of volatile organic compounds profiles of roasted Coffea arabica extracts produced by supercritical and conventional solvents
Authors: de Toledo Paulo R. A. B. , de Melo Marcelo M. R. , Rodrigues Vítor H. , Pezza Helena R. , Rocha Sílvia M. , Toci Aline T. , Pezza Leonardo , Portugal Inês , Silva Carlos M. 
Published: May 2022

SummaryThis work addresses the potential of supercritical fluid extraction (SFE) to design volatile organic compounds (VOCs) profiles using roasted Coffea arabica. On the whole, 57 VOCs were identified by HS‐SPME/GC–MS. A full factorial design was adopted to study the effect of pressure (180 and 300 bar), temperature (40 and 80 °C) and ethanol content (0 and 5 wt.%). The total extraction yield ranged from 1.4 wt.% to 9.8 wt.%. At 180 bar and 80 °C, two extracts exhibited VOCs amount up to 3.5 times higher than the dichloromethane extract. Temperature and pressure favoured VOCs amount and total yield in conflicting ways, and ethanol had a negligible effect on VOCs amount. At 180 bar and 80 °C, the VOCs profile revealed a reinforcement of pyrroles, phenols, cyclopentenes and pyrans, at the expense of pyridines, carboxylic acids and furans. Hence, this essay evidences the potential of SFE to engineer coffee VOCs profiles.