bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reversible and Irreversible HAuCl4 Binding to DNA for Seeded Gold Nanoparticle Growth and Opposite DNA and Aptamers Colorimetric Sensing Outcomes
Authors: Lu Chang , Zandieh Mohamad , Zheng Jinkai , Liu Juewen 
Published: August 2022

AbstractDNA‐directed seeded growth of gold nanoparticles has been used for the development of aptamer‐based biosensors with the assumption that target analytes can modulate the adsorption of aptamers to the gold seeds and thus affect the growth reaction. To understand the reaction, the effect of single‐ and double‐stranded DNA is first examined, and it is found that they have a similar promotion effect of anisotropic growth, suggesting that DNA cannot be detected using this method. By studying the interaction between HAuCl4 and DNA, both weak reversible binding and strong irreversible binding are identified, with the latter becoming dominating with a longer incubation time. Single‐ and double‐stranded DNA have similar weak binding to HAuCl4, and this weak binding is more important for the growth reaction. Then three aptamers are tested, where only cortisol appeared to modulate its aptamer adsorption and the growth reaction reflected aptamer binding. Hg2+ shows no advantage for its aptamer, and quinine induced aggregation of AuNPs cannot be detected by this reaction either. Therefore, each aptamer target needs to be individually studied to test if this method is applicable. It is also noted that DNA and aptamers have opposite outcomes for the target‐dependent growth reactions.
Application of CD and Eu3+ Dual Emission MOF Colorimetric Fluorescent Probe Based on Neural Network in Fe3+ Detection
Authors: Zheng Yuewei , Wang Xuan , Guan Zhihao , Deng Junjie , Liu Xinghai , Li Houbin , Zhao Pingping 
Published: August 2022

AbstractA new highly fluorescent hybrid material (CD@Eu‐MOF) is synthesized by encapsulating carbon dots (CD) prepared from citric acid and ethylenediamine on the basis of a metal‐organic framework (MOF) prepared from Eu3+ and 1,2,4‐benzenetricarboxylic acid. The prepared composite not only maintains the excellent fluorescence properties of CD and Eu3+, respectively, but also forms a dual‐emission fluorescence system, and the system has good stability in an aqueous solution. It is further used as a novel fluorescent probe for the detection of Fe3+, which can effectively exclude the interference of other metal ions from the detection, and the intensity ratio of IEu/ICD of CD@Eu‐MOF material has a good linear relationship with Fe3+ in the range of 1–200 µm. In this study, computer vision and backpropagation (BP) neural networks are used to train and fit the sample data, and it is verified that the actual fluorescence color of CD has a good linear relationship with Fe3+ concentration. In addition, the BP neural network also verifies that the fluorescence spectrum data of CD@Eu‐MOF also have a good linear relationship with Fe3+ concentration. This study provides a new method for the fabrication of ratio and colorimetric Fe3+ fluorescence sensors.
Effect of ear exercises on hearing loss in patients with nasopharyngeal carcinoma after radiotherapy
Authors: Lu Juan , Zhang Hui , Xu Dejing , Shi Lingyun , Wen Jing 
Published: August 2022

AbstractThe objective of the study is to explore the effect of an ear health exercise on hearing loss of patients with nasopharyngeal carcinoma receiving radiotherapy. One hundred and seventeen patients diagnosed with nasopharyngeal carcinoma from June 2018 to January 2020 were selected as research subjects randomly divided into three groups. Thirty‐eight cases were in experimental group 1 and given an ear health exercise for 6 months, 38 cases were in experimental group 2 and given an ear health exercise for 12 months, and 41 cases in control group only received hearing health education. The hearing loss of three groups was compared before intervention and at 6 and 12 months after intervention. The value of the average audibility threshold of air conduction, the occurrence rate of abnormal acoustic immittance (ear), the rate of tympanic cavity effusion, and occur rate of secretory otitis media in two experimental groups were lower than control group among different time points. The above indicators of experimental group 2 were lower than those of group 1 (p < .05). The total effective rate of hearing improvement in experimental groups 1 and 2 was higher than that of control group after the intervention. Besides, the total effective rate in experimental group 2 was higher than that in group 1, and the difference was statistically significant (p < .05). There was no serious adverse reaction. An ear health exercise can reduce hearing loss of patients with nasopharyngeal carcinoma receiving radiotherapy. It can be used as daily rehabilitation measures to prevent or delay hearing loss for these patients.
Elucidating tricuspid Doppler signal interpolation and its implication for assessing pulmonary hypertension
Authors: Dual Seraina A. , Verdonk Constance , Amsallem Myriam , Pham Jonathan , Obasohan Courtney , Nataf Patrick , McElhinney Doff B. , Arunamata Alisa , Kuznetsova Tatiana , Zamanian Roham , Feinstein Jeffrey A. , Marsden Alison , Haddad François 
Published: August 2022

AbstractDoppler echocardiography plays a central role in the assessment of pulmonary hypertension (PAH). We aim to improve quality assessment of systolic pulmonary arterial pressure (SPAP) by applying a cubic polynomial interpolation to digitized tricuspid regurgitation (TR) waveforms. Patients with PAH and advanced lung disease were divided into three cohorts: a derivation cohort (n = 44), a validation cohort (n = 71), an outlier cohort (n = 26), and a non‐PAH cohort (n = 44). We digitized TR waveforms and analyzed normalized duration, skewness, kurtosis, and first and second derivatives of pressure. Cubic polynomial interpolation was applied to three physiology‐driven phases: the isovolumic phase, ejection phase, and “shoulder” point phase. Coefficients of determination and a Bland−Altman analysis was used to assess bias between methods. The cubic polynomial interpolation of the TR waveform correlated strongly with expert read right ventricular systolic pressure (RVSP) with R2 > 0.910 in the validation cohort. The biases when compared to invasive SPAP measured within 24 h were 6.03 [4.33; 7.73], −2.94 [1.47; 4.41], and −3.11 [−4.52; −1.71] mmHg, for isovolumic, ejection, and shoulder point interpolations, respectively. In the outlier cohort with more than 30% difference between echocardiographic estimates and invasive SPAP, cubic polynomial interpolation significantly reduced underestimation of RVSP. Cubic polynomial interpolation of the TR waveform based on isovolumic or early ejection phase may improve RVSP estimates.
Preparation of Nanostructured Graphene Oxide and Its Application in Drug Loading and Sustained Release
Authors: Fu Dongsheng , You Jinhui , Guo Ruijie , Zhang Jie , Li Qiang , Wen Jing , Wang Huifang , Yan Hong 
Published: August 2022

AbstractGraphene oxide (GO) and its derivatives are considered as a promising drug carrier in tumor therapy due to their excellent biocompatibility. Here, a series of nanostructured GO with long‐range ordered lamellar or hexagonal structure were prepared by lyotropic liquid crystals (LLCs) templating strategy and used as drug carriers. The nanostructure was verified via polarized‐light optical microscopy (POM), low angle X‐ray diffraction (XRD) and transmission electron microscopy (TEM), which showed that the interlayer spacing or pore size was determined by the carbon chain length of templating molecular. 5‐fluorouracil (5‐Fu), doxorubicin (DOX) and docetaxel (DOC) which had gradually increased molecular size were chosen as model drugs, and the highly ordered nanochannels can be used as space for adsorption and diffusion of drug molecules. Ultraviolet spectrometer and simulated release test in vitro were used to determine drug loading capacity and drug release performance. The results showed that larger pore diameter/layer spacing was beneficial to the adsorption and diffusion of drug molecules, especially those with shorter molecule size. Besides, the water‐solvable DOX exhibited fast release rate than the hydrophobic 5‐Fu and DOC. The in vitro cytotoxicity assay demonstrated the good biocompatibility of both the pristine GO and the nanostructured GO.
Poly(methyl methacrylate) Nanoparticles Grafted with Gold‐L‐Cysteine as a Water Cleaning Material for the Photocatalytic Degradation of Paracetamol
Authors: Agoudjil Karima , Haddadine Nabila , Davidson Anne , Barama Siham , Abouzeid Khaled , Barama Akila , Selmane Mohamed , Bouslah Naima , Benaboura Ahmed , Barillé Régis , Samy El‐Shall M. 
Published: August 2022

AbstractHere, we report the photocatalytic degradation of aqueous paracetamol (Acetaminophen or N‐acetyl‐p‐aminophenol, APAP) as a drug model under visible light in presence of opal and inverse opal photonic crystals (PC) derived from gold‐L‐cysteine and grafted on poly(methyl methacrylate) (PMMA) nanoparticles. The L‐cysteine grafted PMMA colloidal nanoparticles with average diameters of 170 and 200 nm were prepared by emulsion polymerization. The reduction of the gold ions (HAuCl4) by L‐cysteine resulted in the formation of gold nanoparticles (AuNPs) attached to the PMMA colloidal particles. The opal photonic crystals Au@PC170 and Au@PC200, formed by self‐assembly of gold‐L‐cysteine‐PMMA nanoparticles, were treated by the sol‐gel method in the presence of a silica precursor. Therefore, two inverse opal photonic crystals (IOPCs): Au@SiO2(1) and Au@SiO2(2) were isolated following the polymer removal by calcination at 500 °C. The photocatalytic degradation of paracetamol (APAP) as a drug model was performed in the presence of the opal and inverse opal PCs. The results showed that 18.9 % of APAP photodegradation was obtained using the opal photonic crystals Au@PC200 after 2.5 hours, whereas 70.3 % of the photodegradation occurred instantaneously with the silica inverse opal photonic crystals Au@SiO2(2). Consequently, the inverse opal photonic crystals were proposed as a potential effective water cleaning photocatalyst under visible light irradiation.
Structural Exploration and Protein Binding Efficiencies of Binuclear Dioxidomolybdenum(VI) Complexes Constructed from ONO Chelator and Linear N−N Ditopic Spacer
Authors: Sarkar Oiendrilla , Roy Malini , Biswal Debanjana , Ranjan Pramanik Nikhil , Paul Suvendu , Drew Michael G. B. , Chakrabarti Syamal 
Published: August 2022

AbstractThis communication describes the syntheses, spectroscopic characterizations and crystal structures of two binuclear dioxidomolybdenum(VI) complexes 1 and 2 of general formula [MoO2L]2(N−N) with ONO donor ligands obtained by the condensation of benzoyl acetone with salicylhydrazide (H2L1) and anthranylhydrazide (H2L2) and spacer 1,2‐bis(4‐pyridyl)ethene (bpe). The crystal structures of these complexes have been solved by single crystal X‐ray crystallography. Both the complexes 1 and 2 are centrosymmetric and each Mo centre exhibits a distorted octahedral geometry. The complexes give rise to 3D supramolecular architectures with the formation of cavities via hydrogen bonding and C−H⋅⋅⋅π stacking interactions. Extensive DFT calculations are carried out to compare the structural parameters of the complexes with the experimental data and energy of frontier molecular orbitals are also calculated. The intermolecular interactions in the crystal structures are also studied by the Hirshfeld surface analysis. The redox behaviour of complexes has been examined by cyclic voltammetry. The binding affinity and binding mode of the complexes towards BSA has been explored by absorption and fluorescence titration method. Both the complexes exhibit fluorescence resonance energy transfer from protein to the complexes. The molecular docking investigations are also carried out to get a deeper insight into the binding mechanism.
Fabrication of N‐doped Porous Carbon Materials by Biomass Carbonization for Energy Storage, Electroanalysis and Metal Ion Removal
Authors: Xu Hui , Dong Lina , Yu Jinzhi , Yuan Baiqing , Li Mei , Jiang Tingting , Wang Hua 
Published: August 2022

AbstractIn this work, nitrogen‐doped porous carbons (NDPCs) were prepared by one‐step carbonization of biomass using Sargassum thunbergii as a model for energy storage, electroanalysis, and metal ion removal. The pore structures of NDPCs can be adjusted by changing the pyrolysis temperature (600–800 °C). It was discovered that NDPCs‐700 as a supercapacitor electrode material could display acceptable specific capacitance of 177 F g−1 in 6 M KOH aqueous electrolyte at current density of 0.2 A g−1 with good cycling stability (capacitance retention of 95 % after 2000 cycles), owing to its unique micro‐meso hierarchical pore structure, good conductivity and high nitrogen content (4.61 %). Also, it could act as an electrochemical sensing material, showing good electrocatalytic performance for dopamine (DA) detection in the dynamic detection range of 1.0 to 120 μM with a detection limit of 0.382 μM. Besides, the so fabricated multifunctional material can allow for the removal of metal ions like Hg2+ with high efficiency.
Advanced security testing using a cyber‐attack forecasting model: A case study of financial institutions
Authors: Qasaimeh Malik , Hammour Rand Abu , Yassein Muneer Bani , Al‐Qassas Raad S. , Torralbo Juan Alfonso Lara , Lizcano David 
Published: August 2022

AbstractAs the number of cyber‐attacks on financial institutions has increased over the past few years, an advanced system that is capable of predicting the target of an attack is essential. Such a system needs to be integrated into the existing detection systems of financial institutions as it provides them with proactive controls with which to halt an attack by predicting patterns. Advanced prediction systems also enhance the software design and security testing of new advanced cyber‐security measures by providing new testing scenarios supported by attack forecasting. This present study developed a model that forecasts future network‐based cyber‐attacks on financial institutions using a deep neural network. The dataset that was used to train and test the model consisted of some of the biggest cyber‐attacks on banking institutions over the past three years. This provided insight into new patterns that may end with a cyber‐crime. These new attacks were also evaluated to determine behavioral similarities with the nearest known attack or a combination of several existing attacks. The performance of the forecasting model was then evaluated in a real banking environment and provided a forecasting accuracy of 90.36%. As such, financial institutions can use the proposed forecasting model to improve their security testing measures.
Design and implementation of a fully transparent partial abort support for software transactional memory
Authors: Pellegrini Alessandro , Di Sanzo Pierangelo , Piccione Andrea , Quaglia Francesco 
Published: August 2022

AbstractSoftware transactional memory (STM) provides synchronization support to ensure atomicity and isolation when threads access shared data in concurrent applications. With STM, shared data accesses are encapsulated within transactions automatically handled by the STM layer. Hence, programmers are not requested to use code‐synchronization mechanisms explicitly, like locking. In this article, we present our experience in designing and implementing a partial abort scheme for STM. The objective of our work is threefold: (1) enabling STM to undo only part of the transaction execution in the case of conflict, (2) designing a scheme that is fully transparent to programmers, thus also allowing to run existing STM applications without modifications, and (3) providing a scheme that can be easily integrated within existing STM runtime environments without altering their internal structure. The scheme we designed is based on automated software instrumentation, which injects into the application capabilities to undo the required portions of transaction executions. Further, it can correctly undo also non‐transactional operations executed on the stack and the heap during a transaction. This capability allows programmers to write transactional code without concerns about the side effects of aborted transactions on both shared and thread‐private data. We integrated and evaluated our partial abort scheme within the TinySTM open‐source library. We analyze the experimental results we achieved with common STM benchmark applications, focusing on the advantages and disadvantages of the proposed solutions for implementing our scheme's different components. Hence, we highlight the appropriate choices and possible solutions to improve partial abort schemes further.
Improving early compressive strength of precast concrete by increasing active silicon content
Authors: Zhang Zhongzhe , Ji Yongsheng , Ma Zhanguo , Geng Ou , Gao Furong , Xu Zhishan , Zhang Jie , Xue Qi 
Published: August 2022

AbstractIn order to make the precast concrete reach the design strength quickly, by increasing the active silicon content of the precast concrete, the influence mechanism of the active silicon on the early compressive strength of the precast concrete was studied. The early hydration process, early pore structure, and chemical composition of precast concrete mixed with different types and dosages of water‐soluble active silicon materials (WASM) were characterized through heat of hydration test, mercury intrusion porosimetry (MIP), X‐ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT‐IR). The increase of active silicon content in precast concrete can greatly improve the early compressive strength of precast concrete (PC) under steam curing conditions. The increase of active silicon content in PC can greatly improve the early hydration process of cement and accelerate the rate of early cement hydration heat release. The addition of active silicon in the early stage of cement hydration can promote the rapid conversion of Ca(OH)2 generated in the gelling system to high‐strength CSH gel. A large amount of high‐strength CSH gel is formed in the early stage of cement hydration, which can promote the formation of a dense internal structure of PC as soon as possible, thereby promoting the rapid improvement of the early compressive strength of PC.
The essential role of community in teaching and learning
Authors: Wehlburg Catherine M. 
Published: August 2022

AbstractLearning can happen anywhere but it often happens best when it occurs in connection with others. When the COVID‐19 pandemic happened and caused many institutions to move all instruction to virtual modalities, many faculty and students expressed feelings of isolation and loneliness. In addition to that, anecdotal conversations with faculty and students pointed to the possibility that there was less learning that occurred during the pandemic in many instances as there was not the same focus on coursework, homework, and lectures. Perhaps the lack of feelings of connection and community with other learners had some direct impact on the level of learning.
Effect of long‐term management of hypoadrenocorticism on the quality of life of affected dogs and their owners
Authors: Hupfeld Julia , Dölle Michael , Volk Holger , Rieder Johanna 
Published: August 2022

AbstractBackgroundThe treatment of canine adrenal insufficiency consists of hormone substitution and requires high owner compliance and intense human–dog interaction. This might affect the quality of life (QoL) of owners and their pets. The aim of the study was to evaluate the impact of hypoadrenocorticism and its treatment on the QoL of dogs and their owners.MethodsOwners completed a web‐based survey that contained items concerning signalment, owner QoL, dog QoL and long‐term therapy.ResultsThree hundred and twenty‐two owners participated. Most owners feared an adrenal crisis. Approximately half of the participants reported that the bond between them and their pet increased after diagnosis. Although many participants felt that their own QoL was not affected by their dog's disease, worries about costs and leaving their dog unsupervised were frequently reported. Half of the study participants increased their dog's glucocorticoid doses when a stressful situation was foreseeable (‘boosting’ of therapy). Some administered hydrocortisone, mostly switched from prednisolone, resulting in a reduction in side effects.ConclusionsSpecial attention should be given to glucocorticoid therapy and owner's QoL. The overall worry of an adrenal crisis might increase caregivers’ burden, reducing their overall QoL. Hydrocortisone might be a safe alternative to prednisolone, but further research is necessary to evaluate its long‐term efficacy and safety in dogs.
Caecal gastrointestinal stromal tumour with secondary immune‐mediated haemolytic anaemia in a cocker spaniel
Authors: Cattaneo Giulia , Schiavo Luca , Bochyńska Diana , Hughes Katherine , Dobson Jane M. , McCallum Katie E. 
Published: August 2022

AbstractThe present case report documents a paraneoplastic immune‐mediated haemolytic anaemia secondary to a gastrointestinal stromal tumour of the caecum in a female neutered cocker spaniel. The dog was presented with a history of acute onset lethargy and anorexia. Investigations revealed a mildly regenerative, Coombs’ test‐positive anaemia with spherocytosis and auto‐agglutination. Abdominal ultrasonography documented a concurrent focal caecal mass. Surgical resection of the mass resulted in complete resolution of the immune‐mediated haemolytic anaemia; immunosuppressive treatment was not required at any stage. The histopathological and immunohistochemical findings supported the diagnosis of a gastrointestinal stromal tumour. To the authors’ knowledge, this is the first report of a paraneoplastic immune‐mediated haemolytic anaemia secondary to a gastrointestinal stromal tumour in a dog and demonstrates a rare case of remission of immune‐mediated haemolytic anaemia in response to surgical resection of the tumour alone.
New Interventions by silicone grease in synthesis
Authors: Werner Daniel , Rad Nazli E. , Guo Zhifang , Deacon Glen B. , Junk Peter C. 
Published: August 2022

AbstractIn redox‐transmetallation protolysis (RTP) reactions in tetrahydrofuran (thf) between excess scandium or cerium metal, Hg(C6F5)2 and 3,5‐dimethylpyrazole (Me2pzH) in silicone greased Schlenk flasks, formation of the 3,5‐dimethyl‐1‐pyrazolyl(dimethyl)siloxide (Me2pzSiMe2O) ligand was observed. Thus the former reaction gave [Sc2(Me2pz)4(Me2pzSiMe2O)2] 1 in good yield, whilst the latter gave a mixture of [Ce4O(Me2pz)9(Me2pzSiMe2O)2] 2 a, [Ce4O(Me2pz)11] 2 b, both mixed oxidation state species, and the CeIV complex [Ce(Me2pz)4(Me2pzH)] 2 c.
Exact solution of the plane problems for poroelastic rectangle and semi‐strip
Authors: Zhuravlova Zinaida 
Published: August 2022

AbstractThe exact solutions of the plane problems of poroelasticity for a rectangle and a semi‐strip are derived in the article. The original problems are reduced to one‐dimensional problems with the help of finite and semi‐infinite Fourier transforms for a rectangle and a semi‐strip, respectively. The one‐dimensional boundary value problems are formulated in vector form, and the apparatus of matrix differential calculation is used. Analytical formulas for displacements, stress, and pore pressure are derived for the rectangle and semi‐strip. The investigation of stress and pore pressure for different load types and different poroelastic materials is done for the rectangle and semi‐strip.