bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anion complexes of diborane derivatives inserted to benzene
Authors: López‐Sánchez Rubén , Oliva‐Enrich Josep M. , Alkorta Ibon , Elguero José 
Published: July 2022

AbstractThe complexes formed between three molecules where the diboryl units (HBH2BH) replace the C2H2 moiety in benzene (B6H12, C2B4H10, and C4B2H8) and 10 anions (H−, F−, Cl−, Br−, OH−, CCH−, CH3−, CN−, N3−, and CNO−) have been studied using MP2 computational methods with the complete basis set (CBS) extrapolation scheme. The stability of the complexes for a given anion increases with the number of diborane units in the molecules, and these energy values are correlated with the presence of different anions and number of diborane units. The electron density of the complexes has been characterized and analyzed using the quantum theory of atoms in molecules (QTAIM) and electron density shift (EDS) models.
An internal‐model‐based event‐triggered strategy for rendezvous with connectivity preservation problem of multi‐agent systems
Authors: Wu Xun , Dong Yi 
Published: July 2022

AbstractIn this article, an internal‐model‐based event‐triggered control is proposed for the rendezvous problem of linear uncertain multi‐agent systems. Our approach is not only robust to parametric uncertainty and external disturbances, but also capable of preserving the connectivity of the position‐dependent time‐varying communication network. The event‐triggered mechanism is in a piecewise constant form and thus can be directly implemented in the digital platform. Technically, different from traditional internal model design, a class of distributed dynamic compensators are designed based on sampled relative position and velocity signals to convert the rendezvous problem into a stabilization with connectivity problem of a special augmented system, which is then solved by a piecewise constant stabilizer. Finally, it is proved that the rendezvous problem of the original system is solvable by stabilizing such augmented system and excluding Zeno behavior.
A switched system approach to exponential filtering design for Takagi–Sugeno fuzzy systems with sampled‐data measurements subject to packet dropouts
Authors: Wang Meng , Yan Huaicheng , Li Zhichen , Tian Yongxiao 
Published: July 2022

AbstractThis article studies the problem of exponential filtering design for Takagi–Sugeno fuzzy systems with sampled‐data measurements under the data packet dropout phenomenon. A novel switched system approach is developed, and thus the resulting filtering error system is rewritten in a time‐varying delayed switched system form. Based on novel piecewise time‐dependent Lyapunov functionals, sufficient conditions are obtained to guarantee the exponential stability with performance of the filtering error system. The full‐/reduced‐order filter design results in the form of solving a set of linear matrix inequalities are obtained. Finally, simulation results are provided to show the effectiveness of the method.
Expeditious Electrochemical Synthesis of Mesoporous Chalcogenide Flakes: Mesoporous Cu2Se as a Potential High‐Rate Anode for Sodium‐Ion Battery
Authors: Nagaura Tomota , Li Jinliang , Fernando Joseph F. S. , Ashok Aditya , Alowasheeir Azhar , Nanjundan Ashok Kumar , Lee Sukho , Golberg Dmitri V. , Na Jongbeom , Yamauchi Yusuke 
Published: July 2022

AbstractNanostructured copper selenide (Cu2Se) attracts much interest as it shows outstanding performance as thermoelectric, photo‐thermal, and optical material. The mesoporous structure is also a promising morphology to obtain better performance for electrochemical and catalytic applications, thanks to its high surface area. A simple one‐step electrochemical method is proposed for mesoporous chalcogenides synthesis. The synthesized Cu2Se material has two types of mesopores (9 and 18 nm in diameter), which are uniformly distributed inside the flakes. These materials are also implemented for sodium (Na) ion battery (NIB) anode as a proof of concept. The electrode employing the mesoporous Cu2Se exhibits superior and more stable specific capacity as a NIB anode compared to the non‐porous samples. The electrode also exhibits excellent rate tolerance at each current density, from 100 to 1000 mA g−1. It is suggested that the mesoporous structure is advantageous for the insertion of Na ions inside the flakes. Electrochemical analysis indicates that the mesoporous electrode possesses more prominent diffusion‐controlled kinetics during the sodiation–desodiation process, which contributes to the improvement of Na‐ion storage performance.
Transition Metal (Co, Ni, Fe, Cu) Single‐Atom Catalysts Anchored on 3D Nitrogen‐Doped Porous Carbon Nanosheets as Efficient Oxygen Reduction Electrocatalysts for Zn–Air Battery
Authors: Zhang Mengtian , Li Hao , Chen Junxiang , Ma Fei‐Xiang , Zhen Liang , Wen Zhenhai , Xu Cheng‐Yan 
Published: July 2022

AbstractExploring highly active and cost‐efficient single‐atom catalysts (SACs) for oxygen reduction reaction (ORR) is critical for the large‐scale application of Zn–air battery. Herein, density functional theory (DFT) calculations predict that the intrinsic ORR activity of the active metal of SACs follows the trend of Co > Fe > Ni ≈ Cu, in which Co SACs possess the best ORR activity due to its optimized spin density. Guided by DFT calculations, four kinds of transition metal single atoms embedded in 3D porous nitrogen‐doped carbon nanosheets (MSAs@PNCN, M = Co, Ni, Fe, Cu) are synthesized via a facile NaCl‐template assisted strategy. The resulting MSAs@PNCN displays ORR activity trend in lines with the theoretical predictions, and the Co SAs@PNCN exhibits the best ORR activity (E1/2 = 0.851 V), being comparable to that of Pt/C under alkaline conditions. X‐ray absorption fine structure (XAFS) spectra verify the atomically dispersed Co‐N4 sites are the catalytically active sites. The highly active CoN4 sites and the unique 3D porous structure contribute to the outstanding ORR performance of Co SAs@PNCN. Furthermore, the Co SAs@PNCN catalyst is employed as cathode in Zn–air battery, which can deliver a large power density of 220 mW cm–2 and maintain robust cycling stability over 530 cycles.
Nanostructures and catalytic atoms engineering of tellurium‐based materials and their roles in electrochemical energy conversion
Authors: Li Tiantian , Deng Yuting , Rong Xiao , He Chao , Zhou Mi , Tang Yuanjiao , Zhou Hongju , Cheng Chong , Zhao Changsheng 
Published: July 2022

AbstractWith the dramatic developments of renewable and environmental‐friendly electrochemical energy conversion systems, there is an urgent need to fabricate durable and efficient electrocatalysts to address the limitation of high overpotentials exceeding thermodynamic requirements to facilitate practical applications. Recently, tellurium‐based nanomaterials (Te NMs) with unique chemical, electronic, and topological properties, including Te‐derived nanostructures and transition metal tellurides (TMTs), have emerged as one of the most promising electrocatalytic materials. In the absence of comprehensive and guiding reviews, this review comprehensively summarizes the main advances in designing emerging Te NMs for electrocatalysis. First, the engineering strategies and principles of Te NMs to enhance their electrocatalytic activity and stability from the nanostructures to the catalytic atoms are discussed in detail, especially on the chemical/physical/multiplex templating strategies, heteroatom doping, vacancy/defect engineering, phase engineering, and the corresponding mechanisms and structure‐performance correlations. Then, typical applications of Te NMs in electrocatalysis are also discussed in detail. Finally, the existing key issues and main challenges of Te NMs for electrocatalysis are highlighted, and the development trend of Te NMs as electrocatalysts is expounded. This review provides new concepts to guide future directions for developing Te NMs‐based electrocatalysts, thereby promoting their future wide applications in electrochemical energy systems.
Identifying and expression analysis of WD40 transcription factors in walnut
Authors: Chen Shuwen , Li Dapei , Chen Sisi , He Jianing , Wang Zengbin , Yang Guiyan , Lu Zhoumin 
Published: July 2022

AbstractWalnut (Juglans regia L.) is an important woody oil plant and will be affected by abiotic and biological stress during its growth and development. The WD‐repeat (WD40) protein is widely involved in plant growth, development, metabolism, and abiotic stress response. To explore the stress response mechanism of walnut, based on the complete sequencing results of the walnut genome, this study identified and analyzed the physiological, biochemical, genetic structure, and conservative protein motifs of 42 JrWD40 genes, whose expression to abnormal temperature were tested to predict the potential biological function. The results showed that the open reading frame (ORF) of theseWD40 genes were 807–2,460 bp, encoding peptides were 29,610.55–90,387.98 Da covering 268–819 amino acids, as well as 12–112 phosphorylation sites. JrWD40 proteins were highly conserved with four to five WD40 domains and shared certain similarity to WD40 proteins from Arabidopsis thaliana (L.) Heynh. JrWD40 genes can be induced to varying degrees by low and high temperature treatments. JrWD40‐32, JrWD40‐27, JrWD40‐35, and JrWD40‐21 are affected by high temperature more seriously and their expression levels are higher; while JrWD40‐37, JrWD40‐26, JrWD40‐20, JrWD40‐24, and other genes are inhibited under low temperature stress. JrWD40‐40, JrWD40‐28, and JrWD40‐18 were first suppressed with low expression, while as the treatment time prolonging, the expression level was increased under cold condition. JrWD40‐14, JrWD40‐18, JrWD40‐34, and JrWD40‐3 displayed strong transcriptions response to both heat and cold stress. These results indicated that JrWD40 genes can participate in walnut adaptation to adversity and can be used as important candidates for walnut resistance molecular breeding.
Quality and sustainability in the production process: A study of bakeries using an integrated multi‐criteria method based on fuzzy AHP and fuzzy TOPSIS
Authors: Serpa Natália Pedroso , Silva Deoclécio Junior Cardoso da , Wegner Roger da Silva , Stertz Estefana da Silva , Teixeira Clarissa Stefani , Lopes Luis Felipe Dias 
Published: July 2022

AbstractThe objective of the present study is to evaluate, determine, and apply alternatives for improving the quality of the process and the product, with an emphasis on sustainable practices, using an integrated multi‐criteria method. For this purpose, an analysis was conducted at a chain of bakeries, aiming to highlight bottlenecks in the production process and in the product. With the support of a literature review, four criteria and seven alternatives were defined to overcome these bottlenecks and, at the same time, contribute to the sustainability of the organization. For data analysis, six decision makers were interviewed and, following their evaluations, an integrated method based on fuzzy AHP and fuzzy TOPSIS was created. The fuzzy AHP was adopted to establish the importance of the criteria, while the fuzzy TOPSIS was used to evaluate and classify the alternatives developed to bypass the bottlenecks. The results revealed that of the criteria, Criterion “Cr1 – Quality” was prioritized. On the other hand, the alternative with the best performance was “A3 – Physical Layout Reorganization”. Applying this alternative, the study demonstrates the results achieved such as reduction of errors and accident risks, as well as greater fluidity in the productive space. the present study also makes theoretical and managerial contributions to the field, bringing the theory closer to the reality of companies that operate in the food sector.
TamaFlex™—A novel nutraceutical blend improves lameness and joint functions in working horses
Authors: Jain Sandesh , Patil Satyajit G. , Chinta Gopichand , Alluri KrishnaRaju Venkata 
Published: July 2022

AbstractBackgroundLameness is one of the major causes of reduced physical performance and early retirement in working horses. TamaFlex™ (NXT15906F6) is a standardized synergistic anti‐inflammatory botanical formulation containing Tamarindus indica seed extract and Curcuma longa rhizome extract at a 2:1 ratio.MethodsWe conducted a 12‐week single‐center, randomized, blinded, placebo‐controlled trial demonstrating the efficacy of NXT15906F6 in horses with lameness grade 2–4 on the American Association of Equine Practitioners (AAEP) scale. Twenty‐two lame horses were supplemented with NXT15906F6 (2.5 gram/day) or placebo over a period of 84 days. Improvement in lameness over placebo was the primary endpoint, and changes in the levels of rheumatoid factor (RF), anti‐nuclear antibody (ANA), and anti‐cyclic citrullinated peptide (ACC‐peptide) in serum, and pro‐inflammatory cytokines including interleukin (IL‐1β and IL‐6), tumor necrosis factor‐α (TNF‐α) and prostaglandin‐E2 (PGE2) in serum and synovial fluid were the secondary endpoints.ResultsNXT15906F6 exhibited significant relief from lameness in a time‐dependent manner. NXT15906F6 also reduced levels of ANA, PGE2, IL‐1β, TNF‐α and IL‐6. Moreover, NXT15906F6 supplementation is safe and tolerable in alleviating joint pain in lame horses, and protects the joints from further degradation by reducing pro‐inflammatory mediators.ConclusionNXT15906F6 significantly reduces the lameness during walking and trotting, leading to an improvement in their joint flexibility, health, and working performances.
Gene expression ofNectin‐4and its clinical significance in dogs with primary lung adenocarcinoma
Authors: Tamura Kei , Ishigaki Kumiko , Yoshida Orie , Kazuyuki Terai , Sakurai Naoki , Heishima Tatsuya , Fujiyuki Tomoko , Kai Chieko , Asano Kazushi 
Published: July 2022

AbstractBackgroundCanine primary lung adenocarcinoma (CPLA) is suspected by radiography or computed tomography; however, since there are no tumour markers, early diagnosis is difficult, and the prognosis is poor due to increased tumour volume. Nectin‐4 has been reported to be expressed in human lung, ovarian, and pancreatic cancers and promotes tumour growth. It has been reported to be a tumour marker and prognostic factor, and oncolytic virotherapy is being investigated using nectin‐4 as a therapeutic target.ObjectivesThe purpose of this study was to investigate the expression ofNectin‐4in CPLA and its clinical significance in dogs with pulmonary adenocarcinomas.MethodsThe relationships betweenNectin‐4expression and signalling, tumour volume, tumour weight, and prognosis were analyzed in 34 CPLA patients.ResultsThe expression of canineNectin‐4(highNectin‐4) was found in 25 of 34 cases (73%), andNectin‐4expression levels did not show any significant associations with gender, body weight, and tumour stage. However, there was a significant positive correlation betweenNectin‐4expression and tumour volume (r = 0.623,p < 0.05) and tumour weight (r = 0.735,p < 0.05). Regarding prognosis, the median survival time was 427 days in highNectin‐4cases and 420 days in cases with noNectin‐4expression.ConclusionOur study demonstrated thatNectin‐4is highly expressed in CPLA. In addition, nectin‐4 might be a tumour growth factor in CPLA and thus is a promising biomarker for CPLA. Further investigations on nectin‐4 in CPLA are warranted for its diagnosis and novel targets for oncolytic virotherapy.
Shimosato Co-Location of the SLR and GNSS Stations
Authors: Nakamura Yuto , Watanabe Shun-ichi , Yokota Yusuke , Suzuki Akira , Ueshiba Haruka , Seo Noritsune 
Published: July 2022

Abstract
The Japan Coast Guard (JCG) operates Satellite Laser Ranging (SLR) and Global Navigation Satellite System (GNSS) instruments at the Shimosato Hydrographic Observatory (SHO) in Wakayama Prefecture located at the southernmost area of the main island of Japan. SHO is a co-location site where SLR and GNSS can be linked by precisely measuring the local tie vector (relative position) between these two space geodetic techniques. In November 2020, JCG collaborated with the Geospatial Information Authority of Japan (GSI) and performed a local tie survey to precisely determine the local tie vector between the stone marker of the GNSS station and the invariant point (IVP) of the SLR telescope. The IVP of the SLR telescope was determined by an indirect method, in which the reflector targets mounted on the SLR telescope were precisely observed from the surrounding temporary marks. The SLR telescope was rotated at a constant interval during the survey so that the observed target positions form arcs, from which we determined the azimuth and elevation axes; the orthogonal projection of the elevation axis onto the azimuth axis was determined as the IVP. The resulting local tie vector and its variance-covariance information were submitted for the development of the upcoming International Terrestrial Reference Frame 2020 (ITRF2020).
Instantons: thick-wall approximation
Authors: Mukhanov V. F. , Sorin A. S. 
Published: July 2022

Abstract
We develop a new method for estimating the decay probability of the false vacuum via regularized instantons. Namely, we consider the case where the potential is either unbounded from below or the second minimum corresponding to the true vacuum has a depth exceeding the height of the potential barrier. In this case, the materialized bubbles dominating the vacuum decay naturally have a thick wall and the thin-wall approximation is not applicable. We prove that in such a case the main contribution to the action determining the decay probability comes from the part of the solution for which the potential term in the equation for instantons can be neglected compared to the friction term. We show that the developed approximation exactly reproduces the leading order results for the few known exactly solvable potentials. The proposed method is applied to generic scalar field potentials in an arbitrary number of dimensions.
Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses
Authors: Solomon Shiden , Sampathkumar Nirmal Kumar , Carre Ivo , Mondal Mrityunjoy , Chennell George , Vernon Anthony C. , Ruepp Marc-David , Mitchell Jacqueline C 
Published: July 2022

Abstract
Background
A rare coding variant, P522R, in the phospholipase C gamma 2 (PLCG2) gene has been identified as protective against late-onset Alzheimer’s disease (AD), but the mechanism is unknown. PLCG2 is exclusively expressed in microglia within the central nervous system, and altered microglial function has been implicated in the progression of AD.

Methods
Healthy control hiPSCs were CRISPR edited to generate cells heterozygous and homozygous for the PLCG2P522R variant. Microglia derived from these hiPSC’s were used to investigate the impact of PLCγ2P522R on disease relevant processes, specifically microglial capacity to take up amyloid beta (Aβ) and synapses. Targeted qPCR assessment was conducted to explore expression changes in core AD linked and microglial genes, and mitochondrial function was assessed using an Agilent Seahorse assay.

Results
Heterozygous expression of the P522R variant resulted in increased microglial clearance of Aβ, while preserving synapses. This was associated with the upregulation of a number of genes, including the anti-inflammatory cytokine Il-10, and the synapse-linked CX3CR1, as well as alterations in mitochondrial function, and increased cellular motility. The protective capacity of PLCγ2P522R appeared crucially dependent on (gene) ‘dose’, as cells homozygous for the variant showed reduced synapse preservation, and a differential gene expression profile relative to heterozygous cells.

Conclusion
These findings suggest that PLCγ2P522R may result in increased surveillance by microglia, and prime them towards an anti-inflammatory state, with an increased capacity to respond to increasing energy demands, but highlights the delicate balance of this system, with increasing PLCγ2P522R ‘dose’ resulting in reduced beneficial impacts.

Graphical abstract
NPC transplantation rescues sci-driven cAMP/EPAC2 alterations, leading to neuroprotection and microglial modulation
Authors: Martínez-Rojas Beatriz , Giraldo Esther , Grillo-Risco Rubén , Hidalgo Marta R. , López-Mocholi Eric , Alastrue-Agudo Ana , García-García Francisco , Moreno-Manzano Victoria 
Published: July 2022

AbstractNeural progenitor cell (NPC) transplantation represents a promising treatment strategy for spinal cord injury (SCI); however, the underlying therapeutic mechanisms remain incompletely understood. We demonstrate that severe spinal contusion in adult rats causes transcriptional dysregulation, which persists from early subacute to chronic stages of SCI and affects nearly 20,000 genes in total tissue extracts. Functional analysis of this dysregulated transcriptome reveals the significant downregulation of cAMP signalling components immediately after SCI, involving genes such as EPAC2 (exchange protein directly activated by cAMP), PKA, BDNF, and CAMKK2. The ectopic transplantation of spinal cord-derived NPCs at acute or subacute stages of SCI induces a significant transcriptional impact in spinal tissue, as evidenced by the normalized expression of a large proportion of SCI-affected genes. The transcriptional modulation pattern driven by NPC transplantation includes the rescued expression of cAMP signalling genes, including EPAC2. We also explore how the sustained in vivo inhibition of EPAC2 downstream signalling via the intrathecal administration of ESI-05 for 1 week impacts therapeutic mechanisms involved in the NPC-mediated treatment of SCI. NPC transplantation in SCI rats in the presence and absence of ESI-05 administration prompts increased rostral cAMP levels; however, NPC and ESI-05 treated animals exhibit a significant reduction in EPAC2 mRNA levels compared to animals receiving only NPCs treatment. Compared with transplanted animals, NPCs + ESI-05 treatment increases the scar area (as shown by GFAP staining), polarizes microglia into an inflammatory phenotype, and increases the magnitude of the gap between NeuN + cells across the lesion. Overall, our results indicate that the NPC-associated therapeutic mechanisms in the context of SCI involve the cAMP pathway, which reduces inflammation and provides a more neuropermissive environment through an EPAC2-dependent mechanism.
Graphical abstract
Instability of Boundary Layers with the Navier Boundary Condition
Authors: Quarisa Lorenzo , Rodrigo José L. 
Published: July 2022

AbstractWe study the $$L^{\infty }$$

L
∞

stability of the Navier-Stokes equations in the half-plane with a viscosity-dependent Navier friction boundary condition around shear profiles which are linearly unstable for the Euler equation. The dependence from the viscosity is given in the Navier boundary condition as $$\partial _y u = \nu ^{-\gamma }u$$

∂
y

u
=

ν

-
γ

u

for some $$\gamma \in {\mathbb {R}}$$

γ
∈
R

, where u is the tangential velocity. With the no-slip boundary condition, which corresponds to the limit $$\gamma \rightarrow +\infty $$

γ
→
+
∞

, a celebrated result from E. Grenier (Comm. Pure Appl. Math. 53:1067–1091, 2000) provides an instability of order $$\nu ^{1/4}$$

ν

1
/
4

. M. Paddick (Differ. Integral Equ. 27:893–930, 2014) proved the same result in the case $$\gamma =1/2$$

γ
=
1
/
2

, furthermore improving the instability to order one. In this paper, we extend these two results to all $$\gamma \in {\mathbb {R}}$$

γ
∈
R

, obtaining an instability of order $$\nu ^{\vartheta }$$

ν
ϑ

, where in particular $$\vartheta =0$$

ϑ
=
0

for $$\gamma \le 1/2$$

γ
≤
1
/
2

and $$\vartheta =1/4$$

ϑ
=
1
/
4

for $$\gamma \ge 3/4$$

γ
≥
3
/
4

. When $$\gamma \ge 1/2$$

γ
≥
1
/
2

, the result denies the validity of the Prandtl boundary layer expansion around the chosen shear profile.