bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Redox Pathway Leading to the Alkylation of Nucleic Acids by Doxorubicin and Related Anthracyclines: Application to the Design of Antitumor Drugs for Resistant Cancer
Authors: Kocht Tad H. , Taatjes Dylan J. , Fenick David J. , Gaudianot Giorgio 
Published: October 2022

Abstract:
Doxorubicin has been a constituent of antitumor drug protocols for a broad spectrum of cancers for more than two decades. Side effects and resistance continue to be important limitations. Drug targets responsible for both side effects and anti-tumor activity are cell membrane receptors, cell membrane lipids, nucleic acids and topoiso-
merase. Induction of oxidative stress is responsible for most if not all biological activity. An important consequence of oxidative stress is the production of formaldehyde which can subsequently be utilized by the drug for covalent bonding to nucleic acids and other targets as shown by in vitro experiments. Multidrug resistance mechanisms inhibit drug-induced DNA damage, drug uptake, and drug-induced oxidative stress. Synthetic anthracyclines conjugated to formaldehyde circumvent some if not all of the resistance mechanisms. Consequently, anthracycline-formaldehyde conjugates have potential for the treatment of resistant cancer.
Recent Progress in the Development of Tubulin Inhibitors As Antimitotic Antitumor Agents
Authors: Lee Kuo-Hsiung , Shi Qian , Chen Ke , Morris-Natschke Susan L. 
Published: October 2022

Abstract:
Tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors have attracted great attention as antimitotic antitumor agents for chemotherapeutic use. Hundreds of synthetic or semisynthetic tubulin inhibitors have been discovered and developed recently that are related to the natural products colchicine, vinblastine; and taxol. Representatives include allothiocolchicinoids, vinorelbine, and taxotere. This review will describe the recent progress being made in the development of novel antimitotic antitumor tubulin inhibitors. The emphasis has been placed on related research in the author's laboratory, including development of colchicine derivatives and
other colchicine binding site drugs, such as flavonoids and quinolone derivatives. Syntheses and modifications of novel compounds, biological activity evaluation, and structural activity relationships will be discussed as well. Further research will undoubtedly lead to the discovery of additional tubulin inhibitors that have potential for use as anticancer drugs.
Heterocyclic Analogs of DNA Minor Groove Alkylating Agents
Authors: Baraldi P.G. , Cacciari B. , Guiotto A. , Romagnoli R. , Zaid A.N. , Spalluto G. 
Published: October 2022

Abstract:
It is generally accepted that neoplastic transformation is related to genes alteration or oncogene activation. In particular, DNA minor groove binding drugs have been extensively studied through the years in order to influence the regulation of gene expression by means of specific interactions with DNA bases moieties. Pyrrolo[2,l­ c].[l,4].benzodiazepines (PBDs), CC-1065 and distamycins are three classes of minor groove binders which showed interesting cytotoxicity profiles, refined through already reviewed processes of SAR studies.
Among the modifications to the three families of antitumor compounds, heterocyclic substitutions have been extensively applied by many groups in order to either modify the reactivity profile or introduce extra interactions within the minor groove, thus changing the binding site or modulating the binding sequence. The updated material related to these modifications has been rationalised and ordered in order to offer an overview of the argument.
DR (MHC Class 11) Ligands: an Approach to Rheumatoid Arthritis Therapeutics
Authors: Hanson Gunnar J. 
Published: October 2022

Abstract:
The presentation of peptide antigens to T-cells by MHC Class II proteins is a central process in cellular and humoral immune responses. Blockade of this presentation event via synthetic ligands that bind to disease-associated MHCs (such as DR1 and DR4 l may be useful for the treatment of autoimmune diseases such as rheumatoid arthritis, Type I diabetes, multiple sclerosis, lupus erthymatosis and Graves disease. Recently reported synthetic ligands for DR1 and DR4 are short modified peptides (2-7mers) capable of competing at nanomolar concentrations with antigenic peptides for the DR (MHC) binding groove.
Circular External Fixation for Distal Femoral Physeal Injury: A Case Report
Authors: Sato Takahiro , Chida Shuichi , Nozaka Koji , Kobayashi Moto , Sakuraba Tsutomu , Sasaki Ken , Miyakoshi Naohisa 
Published: October 2022

Background:
Distal femoral physeal injuries are a challenging clinical scenario because the injuries have a high risk of growth disturbance. The selected treatments include closed reduction and cast immobilization, percutaneous pin fixation, and cannulated screws or internal fixation, but these treatments have some complications. Circular external fixation enables rigid immobilization and walking with full weight bearing. To the best of our knowledge, there is no article on the results of using circular external fixation for distal femoral physeal injury. This case is the first in which circular external fixation for distal femoral physeal injury is used.

Case Presentation:
A 9-year-old boy was injured in a skiing accident, and his injury was a Salter-Harris type II fracture of the distal femoral epiphysis. We immediately performed percutaneous pin fixation with circular external fixation under general anesthesia. After surgery, he was allowed to walk with full weight bearing. One year after surgery, he had no pain, and his knee regained full extension and 140°flexion.

Conclusion:
We consider circular external fixation to be an effective treatment option because of its rigid immobilization without injury to the plate. However, we and patients must fully acknowledge its difficulties (i.e., pin-site problems, neurologic injury, vascular injury, joint stiffness, and pain, and difficulty sleeping).
Analyzing the Adoption of Clean and Healthy Living Behaviors against COVID-19 Students in Indonesia
Authors: Utami Tri Niswati , Usiono Usiono , Sayekti Retno 
Published: October 2022

The ease of obtaining information influences students adopting the behavior.

Purpose:
To analyze the indicators of clean and healthy living behavior (PHBS) on students and find the effect of information in dealing with COVID-19.

Methods:
This is a quantitative study using a cross-sectional design and was conducted from March – to June 2020. The sample of students at one of the State Universities in Medan City was 352 respondents. Furthermore, the data were collected through a questionnaire, and path analysis determined the relationship between variables x and y. The influence of the respondents’ characteristic variables (X1) on the consumption of nutritious food (Y1), exercise habits (Y2), handwashing habits (Y3), environmental hygiene (Y4), smoking habits (Y5), wearing masks (Y6), water consumption (Y7), consumption of cooked food (Y8), use of health facilities (Y9), the habit of praying (Y10) was analyzed. Meanwhile, the effect of access to information (X2) on the consumption of nutritious food (Y1), exercise habits (Y2), handwashing habits (Y3), environmental hygiene (Y4), smoking habits (Y5), wearing masks (Y6), water consumption (Y7), consumption of cooked food (Y8), use of health facilities (Y9), and praying habit (Y10) was studied.

Results:
This study found that information affected the consumption of nutritious food, exercise habits, handwashing habits, and health facilities with a T-statistic value of 2.603, 1.970, 2.941, and 4.631, respectively, while individual characteristics influenced the use of masks with a value of 2,167.

Conclusion:
Information affects PHBS, and information media is an effective way and impetus for students to adopt the behavior. Furthermore, behavior change will be impacted when information is presented well.
Myocardial extracellular volume expansion in type 2 diabetes is associated with ischemic heart disease, autonomic neuropathy, and active smoking
Authors: Bojer Annemie Stege , Sørensen Martin Heyn , Gæde Peter , Madsen Per Lav 
Published: October 2022

<p> </p>
<p>OBJECTIVE Myocardial interstitial fibrosis expands the extracellular volume (ECV) and is in patients with type 2 diabetes implicated in the development of heart failure. ECV can be determined with gadolinium-contrast magnetic resonance imaging. We investigated which known risk factors for cardiovascular disease were associated with increased ECV in patients with type 2 diabetes.</p>
<p>RESEARCH DESIGN AND METHODS 296 patients with type 2 diabetes and 25 sex and age-matched controls were included in a cross-sectional magnetic resonance imaging study. The influence of risk factors on ECV was investigated by multiple regression analysis.</p>
<p>RESULTS Controls and patients with type 2 diabetes without complications had similar ECV (27.4±2.1% vs 27.9±2.6%, p=0.4). Compared to patients without, ECV was significantly increased in patients with 1≥ complication (29.0±3.3%, p=0.02). Both in univariable analysis and after multivariable adjustment, ischemic heart disease, autonomic neuropathy, and active smoking were associated with increased levels of ECV. Active smoking exhibited the largest effect size (ß=2.0%-point 95% CI 0.7 to 3.3). Former smokers had similar ECV as never-smokers. Albuminuria and systolic blood pressure were inversely associated with ECV in multivariable analysis, but after adjustment for medication suspected to affect ECV, the association with albuminuria was no longer significant (p=0.1). SGLT2i treatment was not significantly associated with reduced ECV (-0.8% 95%CI -1.7 to 0.06, p=0.067).</p>
<p>CONCLUSION Patients with complications of diabetes have increased ECV not seen in patients without complications. Ischemic heart disease, autonomic neuropathy, and active but not former smoking was highly associated with increased ECV.</p>
OVERHEAD OPERATIONAL WATER FOOTPRINT DAN KUALITAS AIR PADA GEDUNG BERTINGKAT (STUDI KASUS GRAHA REKTORAT UNIVERSITAS NEGERI MALANG)
Authors: Yulistyorini Anie , Silvia Sanjaya , Ariestadi Dian 
Published: October 2022

Graha Rektorat Building at the State University of Malang (UM) significantly contributes to water usage. Water usage in the building must be managed and appropriately considered, so it can highly contribute to UM's ranking of UI Green Metric for water conservation indicators. Water usage can be calculated by analysis of overhead operational water footprint. This research aims to analyse green, blue, and grey water footprint, overhead operational water footprint, and the quality of green water on the Graha Rektorat building. The methods used in this research are the quantitative method. This research showed the blue water footprint, green water footprint, and grey water footprint of Graha Rektorat building each by 5628 m3 during January – September 2021, 4361.43 m3/year 18.575 m3/day. Overhead operational water footprint on Graha Rektorat building equal with the value of blue water footprint which is 5628 m3 during January – September 2021. The quality of green water on the Graha Rektorat building does not meet the requirements of Indonesian Minister of Health No. 32 of 2017 concerning environmental health quality standards and water health requirements for hygienic and sanitation purposes. Swimming Pools, Solus Per Aqua, and Public Baths, so as another alternative, green water can be used as a substitute for flushing toilets and watering plants to reduce blue water usage.
Analisis Kelayakan Pengembangan Unit Hemodialisis di Rumah Sakit X di Surabaya
Authors: Dahliana Anita , Winnie Nirmala Santosa  , Ummy Maisarah Rasyidah  
Published: October 2022

Abstract—Indonesia is one country with the kidney failure is quite high, according to the Indonesian Society of Nephrology (PERNEFRI) in the 5th Report of Indonesian Renal Registry, in 2012 there were 16.040 patients with kidney failure but reportedly only 9161 patients were active in hemodialysis in 2012. The increasing incidence of kidney failure that requires hemodialysis services, the more hemodialysis services are needed to meet the needs of patients with kidney failure. Research to assess the development of hemodialysis units at Wiyung Sejahtera Hospital in terms of the size of the market difference, the difference in the cost of single-use and reuse HD units compared to the amount of financing from BPJS. The research method uses a case study conducted at Wiyung Sejahtera Hospital. Data collection is done by means of observation, document study and interviews. The investment analysis method used is the Net Present Value method, the Pay Back Period method and the Internal Rate of Return. Results and Discussion. The results of the SWOT analysis of the hospital are in quadrant I, where the hospital has a great opportunity to increase the number of hemodialysis services. The results of the financial analysis and investment assessment, Wiyung Sejahtera Hospital has a profitable income growth and based on the results of the analysis the investment is relatively safe.
Keywords: feasibility study, hemodialysis, SWOT analysis

Abstrak—Indonesia merupakan salah satu negara dengan angka gagal ginjal cukup tinggi. Perkumpulan Nefrologi Indonesia (PERNEFRI) dalam 5 th Report of Indonesian Renal Registry pada tahun 2012 melaporkan terdapat 16.040 penderita gagal ginjal, tetapi hanya 9.161 pasien yang aktif dalam kegiatan hemodialisa. Meningkatnya insiden gagal ginjal yang memerlukan pelayanan hemodialisa, maka semakin banyak senter pelayanan hemodialisa yang diperlukan untuk memenuhi kebutuhan terhadap pasien gagal ginjal. Tujuan penelitian untuk menilai kelayakan pengembangan unit hemodialisa di RS Wiyung Sejahtera ditinjau dari besarnya pangsa pasar, selisih biaya unit cost HD single use dan reuse dibandingkan dengan besarnya pembiayaan dari BPJS. Metode penelitian menggunakan studi kasus yang dilakukan di RS Wiyung Sejahtera. Pengumpulan data yang dilakukan dengan cara observasi, studi dokumen dan wawancara. Metode analisis investasi yang digunakan adalah metode Net Present Value, metode Pay Back Periode dan Internal Rate of Return. Hasil dan pembahasan. Hasil analisis SWOT RS berada pada kuadran I, dimana RS mempunyai peluang besar meningkatkan jumlah layanan hemodialisa. Hasil analisis keuangan dan penilaian investasi, RS Wiyung Sejahtera memiliki perkembangan pendapatan yang menguntungan dan berdasarkan hasil analiisis investasi relatif aman.
Kata kunci: studi kelayakan, hemodialisis, analisis SWOT
Análisis comparativo de El consentidor y el disentidor, de Bertolt Brecht, y Dogville, de Lars von Trier.
Authors: Hernández Rodríguez María 
Published: October 2022

En el presente artículo se pretenden analizar los elementos literarios comunes que presentan las obras teatrales El consentidor y El disentidor, de Bertolt Brecht y la película Dogville, del director Lars von Trier con el teatro oriental. Para ello, se realiza un estudio comparativo de ambas obras atendiendo a conceptos como la mímesis aristotélica, la ruptura de las unidades (prestando especial atención a la ruptura de la unidad de espacio), la hibridación genérica y la posible metalepsis o ruptura de la lógica ficcional en estas creaciones artísticas. Así mismo, siempre teniendo en cuenta estos elementos, se analizan los rasgos comunes con el teatro oriental.
DOM JE TAMO GDE NAM JE DOBRO
Authors: Ranković Uroš 
Published: October 2022

Nismo srećni dok ne vidimo da napredujemo; a kako bismo došli do toga, moramo bolje upoznati svoju prošlost. Rad „Dom je tamo gde nam je dobro“ predstavlja istraživanje fenomena prostora, kuće, doma, traume i sećanja. Kroz teorijsko istraživanje prikazana su razmišljanja na koji način možemo posmatrati i analizirati prostor, kako tumačimo fenomen dvojnosti kuće i doma, ali i na koji način možemo posmatrati savremenu izvođačku praksu - imerzivnost. Oslanjajući se na teorijske okvire, a posredstvom umetničkog istraživanja i analize umetničkih referenci ova studija pokušava odgovoriti na sledeća pitanja: Kako scenski prikazati naglo prekinuto detinjstvo? Kako u neki prostor upisati atmosferu traumatskog procesa nastalog nakon bombardovanja? Šta za pojedinca znači kuća, a šta dom? Glavni cilj istraživanja bio je formulisanje sopstvene umetničke poetike koja predstavlja sintezu filozofske, teorijske i umetničke misli. Ishod celokupnog istraživanja jeste realizacija imerziv­nog pozorišnog događaja koji je izveden u nekoliko raz­ličitih prostora u Beogradu i to u okviru galerije „Footnote – centre for image and textˮ, art haba „Kulaˮ, poslastičarnice „Milicaˮ i „Bitef teatraˮ. Pored toga, odigravao se na nekoliko gradskih ulica, kao i u minibusu kojim su se prevozili posetioci.
Appendiceal metastasis in ovarian carcinoma-a case report
Authors: Anjum Tooba , Khan Muhammad Mehraiz , Imtiaz Misha , Ismail Usman , Tarin Taha Ahmed 
Published: October 2022

Background:
Being highly malignant, ovarian carcinoma mostly presents at an advanced stage at the time of diagnosis. The appendix could be a potential site for metastatic involvement by ovarian malignancy, however, this is a rare event. Though, its presence can upgrade the tumor to stage III.

Case Presentation:
We report a post-menopausal patient with abdominal mass and distension. Computed tomography scan showed bilateral adnexal lesions, an enlarged enhancing appendix, right hydroureteronephrosis, and ascites. On histopathological correlation, the adnexal lesions turned out to be moderate to poorly differentiated papillary adenocarcinoma with omental and appendiceal involvement by the pathologic process. The patient was then referred to the Oncology department.

Conclusion:
Clinical assessment of appendix or routine appendectomy as part of late-stage ovarian carcinoma management in older patients with omental involvement can lower the risk of appendiceal involvement with subsequent downstaging of the tumor.
Effects of Corn Stalks Ash as A Substitution Material of Cement Due to the Concrete Strength of Rigid Pavement
Authors: Mildawati Roza , Puri Anas , Handayani M. Zaky 
Published: October 2022

Cement is an adhesive material for concrete mixtures in addition to water, fine and coarse aggregates. One of the main ingredients of cement is silica (SiO2) which is originated from the earth's crust. Silica is also available in plants such as corn stalks. This research is aimed to utilize the corn stalk ash (CSA) as an alternative substitution for some cement in concrete for the rigid pavement of road construction. According to the Indonesian standard, the flexural tensile strength should be exceeded at least 4.5 MPa. The flexural tensile strength has also a correlation due to compressive strength.
The concrete materials consisted of the coarse aggregate (river crushed stone) from Kampar River and Danau Bingkuang sands from Kampar District of Riau Province, and Portland Composite Cement from Semen Padang. The CSA was made by burning the dried corn stalks in a steel cylinder can over 24 hours. The content of CSA was varied by 0%, 5%, 7% and 9%. The compressive strength design of concrete was 31,3 MPa. Testing procedures were based on the Indonesian Standard for concrete. The tested specimens have consisted of cube specimens (150 mm x 150 mm x 150 mm) for compressive tests, and beam specimens (150 mm x 150 mm x 600 mm) for flexural strength tests. All specimens were tested on 28 days-age.
The results show that CSA can be used as a partial substitution of cement in concrete. The addition of CSA tends to increase the compressive strength of concrete instead of its flexural tensile strength. The optimum content of CSA was 7% and resulted in an 8.0% and 6.9% increase in compressive and flexural tensile strength due to design respectively. Compressive and flexural tensile strength fulfilled the standard. Flexural tensile strength is obtained by 15% of the compressive strength. Cornstalk ash can be used as a substitution of cement for rigid pavement concrete. It can reduce the utilization of cement and will be potentially cost efficiency.
La vision de la femme chinoise selon Pierre Loti à travers Les derniers jours de Pékin : entre stéréotype et approche journalistique
Authors: HAO Xiaoli 
Published: October 2022

En tant qu'intermédiaire entre « la mystérieuse contrée » et Pierre Loti, la femme exotique qui incarne l'essence d'une civilisation est un thème récurrent dans ses œuvres. Son rôle dans ses fictions mérite d'être étudié. Dans sa description des femmes en Extrême-Orient, par rapport à la femme japonaise, la femme chinoise nous semble bien inconnue, mais son œuvre Les Derniers Jours de Pékin a comme toile de fond la Révolte des Boxers. Du point de vue particulier d'un écrivain exotique et d'un officier militaire, les témoignages qu'il apporte de la société chinoise dans cette « mystérieuse contrée » et, tout particulièrement la description qu'il donne de la « femme exotique » qu'est la femme chinoise dans ce contexte de violence si particulier et d'une autre altérité joueront un rôle non négligeable envers « tout ce qui est différent, étrange, exotique ». Les représentants du groupe le plus vulnérable « la femme chinoise » présentent une image complexe dans l'œuvre : tragique, mystérieuse, courageuse, féerique, etc. Ces personnages féminins vivants et concrets décrivent au lecteur un monde réel d'horreurs qui accompagnent la guerre. À travers le concept du stéréotype, la démarche impressionniste et l'approche journalistique, cet article vise à montrer comment, entre imaginaire romanesque, approche artistique et écriture journalistique, se révèle l'image d'un groupe diversifié de femmes.
Північнокорейська ядерна проблема та можливі сценарії її розвитку
Authors: Pohorielova Іnna 
Published: October 2022

Проаналізовано події на Корейському півострові у контексті висвітлення безпекових інтересів та політики ключових регіональних держав Північно-Східної Азії (США, КНР, РФ, Японії) щодо врегулювання північнокорейської ядерно-ракетної програми, яка залишається проблемою регіонального, міжнародного та глобального рівня. У статті простежується еволюція північнокорейської політики держав, залучених до корейської проблеми з 90-х рр. ХХ ст. до сьогодення; висвітлено різні підходи до вирішення даного питання. Окреслено особливості взаємодії ключових держав з Північною Кореєю та міжкорейських відносин. Розглянуто нові підходи до врегулювання проблеми у зв’язку з приходом до влади у США адміністрації Джо Байдена та нової адміністрації у Республіці Корея. Проаналізувавши політику ключових регіональних країн щодо північнокорейського врегулювання, окреслюються основні можливі сценарії вирішення ядерно-ракетної проблеми КНДР та перспективи розвитку ситуації на Корейському півострові, з урахуванням зовнішньополітичних чинників. З’ясовано, що на сьогодні не є можливою повна денуклеаризація Північної Кореї, а тому актуальним завданням для країн-учасниць є спрямування зусиль для зменшення ядерно-ракетної загрози та зниження існуючого рівня напруженості.
Registro de guacamaya verde (Ara militaris) en los cañones del Río Sabino y Río Seco, Santa María Tecomavaca, Oaxaca, México
Authors: Tehuacán-Cuicatlán Dirección de la Reserva de la Biosfera 
Published: October 2022

Se reporta Ara militaris en dos cañones de la Reserva de la Biosfera Tehuacán-Cuicatlán. En cada sitio se detectó una población de cerca de 20 parejas realizando actividades de anidación.