bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic Analysis of Murine Bone Marrow Very Small Embryonic-like Stem Cells at Steady-State Conditions and after In Vivo Stimulation by Nicotinamide and Follicle-Stimulating Factor Reflects their Germ-Lineage Origin and Multi Germ Layer Differentiation Potential
Authors: Chumak Vira , Sielatycka Katarzyna , Ciechanowicz Andrzej , Bujko Kamila , Ratajczak Mariusz Z. , Kucia Magdalena 
Published: August 2022

AbstractVery small embryonic-like stem cells (VSELs) are a dormant population of development early stem cells deposited in adult tissues that as demonstrated contribute to tissue/organ repair and regeneration. We postulated developmental relationship of these cells to migrating primordial germ cells (PGCs) and explained the quiescent state of these cells by the erasure of differently methylated regions (DMRs) at some of the paternally imprinted genes involved in embryogenesis. Recently, we reported that VSELs began to proliferate and expand in vivo in murine bone marrow (BM) after exposure to nicotinamide (NAM) and selected pituitary and gonadal sex hormones. In the current report, we performed proteomic analysis of VSELs purified from murine bone marrow (BM) after repeated injections of NAM + Follicle-Stimulating Hormone (FSH) that in our previous studies turned out to be an effective combination to expand these cells. By employing the Gene Ontology (GO) resources, we have performed a combination of standard GO annotations (GO-CAM) to produce a network between BM steady-state conditions VSELs (SSC-VSELS) and FSH + NAM expanded VSELs (FSH + NAM VSELs). We have identified several GO biological processes regulating development, organogenesis, gene expression, signal transduction, Wnt signaling, insulin signaling, cytoskeleton organization, cell adhesion, inhibiting apoptosis, responses to extra- and intracellular stimuli, protein transport and stabilization, protein phosphorylation and ubiquitination, DNA repair, immune response, and regulation of circadian rhythm. We report that VSELs express a unique panel of proteins that only partially overlapped with the proteome of BM – derived hematopoietic stem cells (HSCs) and hematopoietic mononuclear cells (MNCs) and respond to FSH + NAM stimulation by expressing proteins involved in the development of all three germ layers. Thus, our current data supports further germ-lineage origin and multi germ layer differentiation potential of these cells.
Graphical abstract
Therapeutic Effects of Salvianolic Acid B on Angiotensin II–Induced Atrial Fibrosis by Regulating Atrium Metabolism via Targeting AMPK/FoxO1/miR-148a-3p Axis
Authors: Liu Jie , Sun Qijuan , Sun Xiaotong , Wang Qian , Zou Guangchen , Wang Dewei , Zhuang Baoxiang , Juan Zhaodong , Zhang Rui , Zhang Daoliang 
Published: August 2022

Abstract
The present study highlights the effects of salvianolic acid B (Sal B) on angiotensin II (Ang II)–activated atrial fibroblasts as well as the associated potential mechanism from the metabonomics perspective. Metabolic profile analysis performed an optimal separation of the Ang II and control group, indicating a recovery impact of Sal B on Ang II–activated fibroblasts (FBs). We found that metabolite levels in the Ang II + Sal B group were reversed to normal. Moreover, 23 significant metabolites were identified. Metabolic network analysis indicated that these metabolites participated in purine metabolism and FoxO signaling pathway. We found that Sal B activated AMP-activated protein kinase (AMPK) phosphorylation, which further promoted FoxO1 activation and increased miR-148a-3p level. We further verified that Sal B modulate the abnormal AMP, phosphocreatine, glutathione (GSH), and reactive oxygen species (ROS) production in Ang II–stimulated FBs. Collectively, Sal B can protect the Ang II–activated FBs from fibrosis and oxidative stress via AMPK/FoxO1/miRNA-148a-3p axis.
Graphical abstract
Effect of copper and silver ions on sequence and DNA methylation changes in triticale regenerants gained via somatic embryogenesis
Authors: Pachota Katarzyna Anna , Orłowska Renata 
Published: August 2022

AbstractSomatic embryogenesis is a plant regeneration method that can be exploited in tissue culture systems for a variety of tasks, such as genetic modification or the selection of somaclones with advantageous characteristics. Therefore, it is crucial to create efficient regeneration procedures and comprehend how medium components affect regeneration effectiveness or the degree of variation created in plant tissue cultures. The level of tissue culture-induced variation in triticale regenerants was examined in the current study in relation to the concentration of copper and silver ions in the induction media as well as the length of time immature zygotic embryo explants were incubated on these media. The high degree of variation (45%) revealed by the methylation-sensitive amplified fragment length polymorphism approach for estimating variation included 38% DNA sequence alterations, 6% DNA demethylation, and 1% de novo DNA methylation. Different levels of variance were found in relation to various DNA sequence settings. The CHG context had the most alterations, whereas CG experienced the fewest; sequence variation predominated in each sequence context. Lower copper ion concentrations showed the most variance. However, it could not be connected to the duration of in vitro culture or the effect of silver ions. Accordingly, we think that altering the concentration of copper ions in the induction medium may throw off the equilibrium of the metabolic processes in which copper is involved, resulting in tissue culture-induced variation.
An Innovative Structural Damage Detection System for Preventive Maintenance of Wind Turbines
Authors: Ozbek Muammer 
Published: August 2022

AbstractThis study aims to develop a novel damage detection and preventive maintenance system that can be used for continuous or periodic monitoring of wind turbine components. The main features of the proposed system such as the measurement technique, data analysis procedure, and damage estimation methodology are described in detail by presenting the results of finite element model-based damage simulations, laboratory experiments, and in-field vibration tests. A hybrid measurement system with accelerometers and an automated infrared laser scanner is used to acquire vibration data with high spatial resolution. The obtained response data are then processed to extract the dynamic properties (e.g., natural vibration periods and mode shapes) of the structure. An efficient damage detection algorithm, which is based on monitoring sudden changes observed in mode shapes, is utilized to determine the location and extent of a possible damage. Within the scope of the work, a novel and simplified version of the widely used mode shape curvature method is developed for the rapid analysis and interpretation of the acquired vibration data. The applicability of the proposed methodology is demonstrated on a 61.5 m long numerical blade model proposed for NREL 5 MW Benchmark wind turbine.
Subordination principle and Feynman-Kac formulae for generalized time-fractional evolution equations
Authors: Bender Christian , Bormann Marie , Butko Yana A. 
Published: August 2022

AbstractWe consider a class of generalized time-fractional evolution equations containing a fairly general memory kernel k and an operator L being the generator of a strongly continuous semigroup. We show that a subordination principle holds for such evolution equations and obtain Feynman-Kac formulae for solutions of these equations with the use of different stochastic processes, such as subordinate Markov processes and randomly scaled Gaussian processes. In particular, we obtain some Feynman-Kac formulae with generalized grey Brownian motion and other related self-similar processes with stationary increments.
Altered Fetal Cardiac Function in Smoking During Pregnancy
Authors: Kaya Serdar , Kandemir Hülya , Kaya Başak , Sanhal Cem Yaşar 
Published: August 2022

AbstractMaternal smoking during pregnancy remains a major public health issue and is associated with adverse perinatal outcomes. This study aimed to evaluate fetal cardiac functions in chronic maternal smoking during pregnancy and to compare them with non-smoker pregnant women. Forty-two smoker pregnant women between 24 and 34 weeks of gestation and gestational age-matched 44 non-smoker pregnant women were enrolled in this cross-sectional study. Fetal cardiac functions were measured using conventional Doppler echocardiography. The peak velocities of the mitral valve during early diastole (E) and atrial contraction (A) were measured, and the E/A ratio was calculated. The following time periods were also calculated; isovolumetric contraction time (ICT), isovolumetric relaxation time (IRT), and ejection time (ET). Then, the fetal left ventricle modified myocardial performance index (Mod-MPI) was calculated. No significant differences were noted between the groups in terms of E, A, and E/A ratio z-scores (p > 0.05). The ICT and IRT z-scores were found to be significantly higher in the study group compared with those in the control group (p = 0.001 and p = 0.034). Mod-MPI z-score was also found significantly higher in the study group than in the control group (p = 0.034). There was no significant difference between the groups in terms of ET (p > 0.05). The signs of systolic, diastolic, and global cardiac dysfunction were demonstrated in fetuses of pregnant women with chronic smoking. It, therefore, merits consideration that the fetal heart is also exposed to the detrimental effects of smoking.
Topological magnets—their basic science and potential applications
Authors: Nakatsuji Satoru 
Published: August 2022

AbstractThe performance limitations of conventional electronic materials pose a major problem in the era of digital transformation (DX). Consequently, extensive research is being conducted on the development of quantum materials that may overcome such limitations, by utilizing quantum effects to achieve remarkable performances. In particular, considerable progress has been made on the fundamental theories of topological magnets and has had a widespread impact on related fields of applied research. An important advance in the field of quantum manipulation is the development of the technology to control the quantum phase of conduction electron wavefunctions through the spin structure. This new technology has led to the realization of phenomena that had been considered infeasible for more than a century, such as the anomalous Hall effect in antiferromagnets and the giant magneto-thermoelectric effect in ferromagnets. This review article presents the remarkable properties of Weyl antiferromagnets and topological ferromagnets, which have been discovered recently. Additionally, this paper examines the current status of how advances in the basic principles of topological magnetism are facilitating the development of next-generation technologies that support the DX era, such as energy harvesting, heat flow sensors, and ultrafast nonvolatile memory.
Transcriptional and post-transcriptional regulation of RNAi-related gene expression during plant-virus interactions
Authors: Gong Qian , Wang Yunjing , Jin Zhenhui , Hong Yiguo , Liu Yule 
Published: August 2022

AbstractAs sessile organisms, plants encounter diverse invasions from pathogens including viruses. To survive and thrive, plants have evolved multilayered defense mechanisms to combat virus infection. RNAi, also known as RNA silencing, is an across-kingdom innate immunity and gene regulatory machinery. Molecular framework and crucial roles of RNAi in antiviral defense have been well-characterized. However, it is largely unknown that how RNAi is transcriptionally regulated to initiate, maintain and enhance cellular silencing under normal or stress conditions. Recently, insights into the transcriptional and post-transcriptional regulation of RNAi-related genes in different physiological processes have been emerging. In this review, we integrate these new findings to provide updated views on how plants modulate RNAi machinery at the (post-) transcriptional level to respond to virus infection.
People, posts, and platforms: reducing the spread of online toxicity by contextualizing content and setting norms
Authors: Record Isaac , Miller Boaz 
Published: August 2022

AbstractWe present a novel model of individual people, online posts, and media platforms to explain the online spread of epistemically toxic content such as fake news and suggest possible responses. We argue that a combination of technical features, such as the algorithmically curated feed structure, and social features, such as the absence of stable social-epistemic norms of posting and sharing in social media, is largely responsible for the unchecked spread of epistemically toxic content online. Sharing constitutes a distinctive communicative act, governed by a dedicated norm and motivated to a large extent by social identity maintenance. But confusion about this norm and its lack of inherent epistemic checks lead readers to misunderstand posts, attribute excess or insufficient credibility to posts, and allow posters to evade epistemic accountability—all contributing to the spread of epistemically toxic content online. This spread can be effectively addressed if (1) people and platforms add significantly more context to shared posts and (2) platforms nudge people to develop and follow recognized epistemic norms of posting and sharing.
Teaching fisheries bycatch: Exploring economic and behavioral drivers of bycatch through a classroom game
Authors: Priestley Mitchell Blaine , Williams J. Forrest , Dissanayake Sahan T. M. 
Published: August 2022

AbstractThis paper presents a pedagogical exercise to explore the economics of price-based fisheries bycatch. In the exercise students experience the economic incentives that lead to bycatch due to highgrading; the discarding of low-value fish. We first discuss existing fisheries economics pedagogical activities and how our exercise is distinct. We then identify over forty economics, environmental studies, geography, management, and philosophy courses where the exercise could be played. Next, we describe the game and share results and student feedback. Finally, we provide discussion prompts and extensions to illustrate how incentives and policies can change fishing behavior to lead to sustainable fisheries.
The impact of social unrest due to systemic racism on underrepresented post-doctoral fellows and early-career faculty
Authors: White Gretchen E. , Proulx Chelsea N. , Rubio Doris M. , Thakar Maya S. , Morone Natalia E. , Mitchell-Miland Chantele , Althouse Andrew D. , Murrell Audrey J. 
Published: August 2022

Abstract

Introduction:
Social unrest tied to racism negatively impacted half of NIH-funded extramural researchers underrepresented (UR) in science. UR early-career scientists encounter more challenges in their research careers, but the impact of social unrest due to systemic racism in this group is unclear. We used mixed methods to describe the impact of social unrest due to systemic racism on mentoring relationships, research, and psychological well-being in UR post-doctoral fellows and early-career faculty.

Methods:
This is a cross-sectional analysis of data collected in September 2021–January 2022 from 144 UR early-career researchers from 25 academic medical centers in the Building Up Trial. The primary outcomes were agreement on five-point Likert scales with social unrest impact statements (e.g., “I experienced psychological distress due to events of social unrest regarding systemic racism”). Thematic analysis was conducted on responses to one open-ended question assessing how social unrest regarding systemic racism affected participants.

Results:
Most participants were female (80%), non-Hispanic Black (35%), or Hispanic (40%). Over half of participants (57%) experienced psychological distress as a result of social unrest due to systemic racism. Participants described direct and indirect discrimination and isolation from other persons of color at their institutions. Twice as many participants felt their mentoring relationships were positively (21%) versus negatively (11%) impacted by social unrest due to systemic racism.

Conclusions:
Experiences with racial bias and discrimination impact the career and well-being of UR early-career researchers. Mentoring relationships and institutional support play an important role in buffering the negative impact of racial injustice for this population.
Revisiting Pan-Slavism in the Contemporary Perspective
Authors: Đorđević Vladimir , Suslov Mikhail , Čejka Marek , Mocek Ondřej , Hrabálek Martin 
Published: August 2022

AbstractIn this article, we examine the literature on the topic of Pan-Slavism that has been published in the last 20 years. We do so by paying particular attention to discussions on contemporary perspectives and manifestations of Pan-Slavism that in our view have been largely missing from academic research. We begin the article by introducing a theoretical conceptualization of Pan-Slavism in general, preparing the ground for our inspection of the academic output in the said period. We then continue by presenting our own contribution to the conceptualization and the current state of the field on Pan-Slavism, suggesting venues that future research may take towards broadening the field that has been and remains narrow. We conclude the article by summarizing the key points made therein.
Possibilities of using the continuous type of UV light on the surface of lor (whey) cheese: impacts on mould growth, oxidative stability, sensory and colour attributes during storage
Authors: Urgu-Ozturk Muge 
Published: August 2022

AbstractThis research paper addresses the hypothesis that the optimum doses of a continuous type of ultraviolet (UV) light applied to the surface of lor (whey) cheese needs to be identified to maximize mould inactivation and shelf life while minimizing quality deterioration. Therefore, the mould inactivation, protein and lipid oxidation products, sensory and colour attributes of lor cheese subjected to different doses of UV light (1.617, 4.018, and 36.832 kJ/m2) in a continuous type of UV system were evaluated. UV treated samples presented mould counts lower than those of untreated ones. UV treatment at more than 4.018 kJ/m2 allowed around 0.7–2.7 log reductions on mould growth during storage. The increase in UV light dose caused significant increases in primary and secondary lipid oxidation products. In particular, the highest doses applied to the surface of cheese samples had the highest values of protein carbonyls, as well as lipid oxidation products. Strong positive correlations were recorded between lipid and protein oxidation markers. Exposure to the highest doses of UV light increased foreign flavour perception, probably due to the oxidative reactions. The results indicated that the application of UV light to the lor cheese surface allowed delaying mould growth during storage but extreme doses could induce lipid and protein oxidation reactions, leading to quality deterioration.
The ‘cosmic terrorist’: Reconsidering sin as personal agent
Authors: McCall Thomas 
Published: August 2022

AbstractAn important contemporary approach to understanding a Pauline account of sin takes sin to be a self or personal agent who acts in the world. This article engages with such a proposal by offering theological analysis. It is argued that the exegetical arguments in favour of the proposal that sin is a personal agent are less than convincing, and it is argued further that the theory encounters serious theological problems.
Implementation of a new Digi-HTA process for digital health technologies in Finland
Authors: Haverinen Jari , Turpeinen Miia , Falkenbach Petra , Reponen Jarmo 
Published: August 2022

Abstract

Objectives
There has been a lack of health technology assessment (HTA) methods for novel digital health technologies (DHTs) such as mHealth, artificial intelligence, and robotics in Finland. The Digi-HTA method has been developed for this purpose. The aim of this study is to determine whether it would be possible to use Digi-HTA recommendations to support healthcare decision-makers. Secondly, from the perspective of companies offering different types of DHT products, this study assesses the suitability of using the Digi-HTA framework to perform HTAs for their products.

Methods
Feedback about Digi-HTA recommendations was collected from healthcare professionals. DHT companies provided input about the Digi-HTA framework. Data were collected via a web-based survey and were analyzed using qualitative methods.

Results
Of the twenty-four healthcare professional respondents, twenty said that the Digi-HTA recommendations contained all the necessary information, and twenty-one found them useful for their work. Respondents hoped that the Digi-HTA recommendations would be better integrated into the decision-making processes and healthcare professionals would be more informed about this new HTA process. The questions of the Digi-HTA framework were applicable for different DHT products based on the responses from DHT companies (n = 8).

Conclusions
According to the study participants, although the Digi-HTA recommendations include clear and beneficial information, their integration into healthcare decision-making processes should be improved. Responses from DHT companies indicate that the Digi-HTA framework would be an appropriate tool for performing assessments for their products. To generalize the findings of this study, more comprehensive studies will be needed.
A theory-based behavioural change communication intervention to decrease the provision of water to infants under 6 months of age in the Republic of Guinea
Authors: Ninamou Nèmanan R , Dupuis Jérémie B , Zagré Noël-Marie , Daffé Mamady , Blaney Sonia 
Published: August 2022

AbstractObjective:In many countries, the provision of water in the early months of a baby’s life jeopardises exclusive breast-feeding (EBF). Using a behavioural theory, this study assessed the impact of a behaviour change intervention on mothers’ intention to act and, in turn, on the water provision in addition to breast milk to their infants under 6 months of age (IU6M) in two regions of Guinea.Design:A quasi-experimental design. Data on individual and environmental factors of the theoretical framework, sociodemographic and outcomes were collected using validated questionnaires before and after the intervention. The outcomes examined were the intention to provide water to IU6M, the provision of water and EBF. Path analyses were performed to investigate pathways by which psychosocial and environmental factors influenced the water provision in addition to breast milk.Setting:Four health centres were assigned randomly to each study’s arm (one control/CG and one intervention group/IG per region).Participants:The sample included 300 mothers of IU6M: 150 per group.Results:In IG, the proportion of mothers providing water decreased from 61 % to 29 % before and after the intervention (P< 0·001), while no difference was observed in CG (P= 0·097). The EBF rate increased in IG (from 24·0 % to 53·8 %,P< 0·001) as opposed to CG (36·7 % to 45·9 %,P= 0·107). An association (P< 0·001) between the intention and the behaviour was observed in both groups.Conclusions:An intervention developed using a sound framework reduces the provision of water among IU6M and improves EBF.