bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jak filozofia może stać się bardziej powszechna i użyteczna dla dobra ludu?
Authors: Herder Johann Gottfried , Michalski Rafał 
Published: May 2022

Przekład i opracowanie:
Rafał Michalski,
Uniwersytet Mikołaja Kopernika w Toruniu
E-mail: Rafal.Michalski@umk.pl
ORCID: 0000-0002-9587-5074
Platelet-rich plasma: how safe is it, and can it cause irreversible blindness?
Authors: McGloin Claudia 
Published: May 2022

Platelet-rich plasma (PRP) is not a new treatment. It has been around for a long time, but it is still very much misunderstood and there are many unanswered questions about it. It is known that it is autologous, meaning that it comes from the patient's own body, and, therefore, allergic reactions cannot occur to one's own blood and the body will not reject it. Despite this, questions still remain around whether it is completely safe. There are several articles that briefly touch on the safety of PRP, but they do not delve into the topic deep enough. As clinicians already know from other medical aesthetic procedures, none are 100% safe and they all come with potential risks and complications. Therefore, it is worth asking whether PRP is any different.In this article, the author discusses PRP from a safety perspective and dissects three clinical papers that highlight that there have been six reported cases of blindness from this treatment.
Improved Radio-Frequency Heating through Application of Wool Insulation during Phytosanitary Treatment of Wood Packaging Material of Low Moisture Content
Authors: Janowiak John J. , Szymona Karolina S. , Dubey Manoj K. , Mack Ron , Hoover Kelli 
Published: May 2022

Abstract
The International Standard of Phytosanitary Measures No. 15 (ISPM-15) requires signatory countries of the International Plant Protection Convention to use approved treatment methods on wood packaging materials used in international trade to significantly reduce the risk of spreading alien species. One of the approved methods utilizes dielectric heating (DH) to raise the temperature in the wood to 60°C through the profile of the workload for 1 minute to eradicate pests. To improve the uniform distribution of heat within a wood workload using radio frequency, a form of DH, we tested the use of a wool blanket as a thermal insulation material for wood pallet components. Three species commonly used in the pallet industry—yellow poplar (Liriodendron tulipifera L.), northern red oak (Quercus rubra L.), and eastern white pine (Pinus strobus L.)—of low moisture content were used to generate matched sets of stringer samples. Internal wood temperatures were monitored continuously during treatment to comply with the ISPM-15 schedule. Applying a wool (keratin) insulation blanket increased the rate of heating, improved heating uniformity throughout the workload, and reduced moisture loss compared to uninsulated controls for some wood species, but not all. These findings were most significant for pallet materials with higher moisture content and more permeability (white pine and yellow poplar). By reducing treatment time, power consumption costs can be reduced using wool insulation when implementing the ISPM-15 DH treatment schedule.
Relationship between skin snip and Ov16 ELISA: Two diagnostic tools for onchocerciasis in a focus in Cameroon after two decades of ivermectin-based preventive chemotherapy
Authors: Djune-Yemeli Linda , Domché André , Nana-Djeunga Hugues C. , Donfo-Azafack Cyrille , Lenou-Nanga Cedric G. , Masumbe-Netongo Palmer , Kamgno Joseph 
Published: May 2022

Background
Onchocerciasis elimination currently relies on repeated ivermectin-based preventive chemotherapy. Current World Health Organization’s guidelines strongly recommend, though with low evidence of certainty, the use of Ov16 serology testing in children younger than 10 years old to assess whether mass drugs administration can be safely stopped. Therefore, more evidences are needed to support the use of this marker as sero-evaluation tool. This study aimed at determining the relationship between microfilaridermia and anti-Ov16 IgG4, and their variation according to age, gender and ivermectin intake history.

Methodology
A cross-sectional survey was conducted in an area where ivermectin-based MDA has been implemented since more than 20 years. A questionnaire was used to record ivermectin intake history for the last 5 years. All volunteers aged ≥2 years were tested for microfilaridermia. IgG4 antibodies against Ov16 antigen were determined using the Standard Diagnostic Ov16 IgG4 ELISA kits and the recombinant anti-Ov16 AbD19432 antibodies. Prevalences, microfilaridermia counts and IgG4 concentrations were compared with regards to age, gender and history of ivermectin intake.

Principal findings
The prevalence of skin microfilariae was 23.4% (95% CI: 23.4–30.8), whereas Ov16 seroprevalence was 53.2% (95% CI: 47.9–58.4). A moderate positive percentage agreement (50.4%) and a high negative percentage agreement (69.2%) was found between skin snip and Ov16 serology in the whole population, while in children aged <10 years, the agreements were higher (positive percentage agreement: 62.6%; negative percentage agreement: 83.5%). In addition, no associations were found between ivermectin intake, Mf counts and estimated IgG4 concentration of participants. Anti-Ov16 IgG4 were higher in individuals harboring microfilariae than their negative counterparts (p<0.0001), though a negative correlation was found between skin microfilarial counts and anti-Ov16 IgG4 levels (r = -0.2400; p = 0.03). No variation in microfilarial counts according to age and gender was observed. Though positively correlated with age (r = 0.4020; p<0.0001), IgG4 was significantly different between the different age classes (p<0.0001).

Conclusion/Significance
Our results revealed moderate positive and negative agreements between parasitological and immunological parameters of onchocerciasis infection after several rounds MDA. Anti-Ov16 IgG4 levels increased with age but decreased with microfilarial counts, suggesting a variation of anti-Ov16 IgG4 as a result of constant exposure and accumulation of infection. This brings evidence sustaining the use of Ov16 serology in children as evaluation tool. However, additional investigations are needed to further reshape the appropriate age range among children aged <10 years old.
An iterative algorithm for optimizing COVID-19 vaccination strategies considering unknown supply
Authors: Bicher Martin , Rippinger Claire , Zechmeister Melanie , Jahn Beate , Sroczynski Gaby , Mühlberger Nikolai , Santamaria-Navarro Julia , Urach Christoph , Brunmeir Dominik , Siebert Uwe , Popper Niki 
Published: May 2022

Background and objective
The distribution of the newly developed vaccines presents a great challenge in the ongoing SARS-CoV-2 pandemic. Policy makers must decide which subgroups should be vaccinated first to minimize the negative consequences of the pandemic. These decisions must be made upfront and under uncertainty regarding the amount of vaccine doses available at a given time. The objective of the present work was to develop an iterative optimization algorithm, which provides a prioritization order of predefined subgroups. The results of this algorithm should be optimal but also robust with respect to potentially limited vaccine supply.

Methods
We present an optimization meta-heuristic which can be used in a classic simulation-optimization setting with a simulation model in a feedback loop. The meta-heuristic can be applied in combination with any epidemiological simulation model capable of depicting the effects of vaccine distribution to the modeled population, accepts a vaccine prioritization plan in a certain notation as input, and generates decision making relevant variables such as COVID-19 caused deaths or hospitalizations as output. We finally demonstrate the mechanics of the algorithm presenting the results of a case study performed with an epidemiological agent-based model.

Results
We show that the developed method generates a highly robust vaccination prioritization plan which is proven to fulfill an elegant supremacy criterion: the plan is equally optimal for any quantity of vaccine doses available. The algorithm was tested on a case study in the Austrian context and it generated a vaccination plan prioritization favoring individuals age 65+, followed by vulnerable groups, to minimize COVID-19 related burden.

Discussion
The results of the case study coincide with the international policy recommendations which strengthen the applicability of the approach. We conclude that the path-dependent optimum optimum provided by the algorithm is well suited for real world applications, in which decision makers need to develop strategies upfront under high levels of uncertainty.
The role and mechanism of tetramethylpyrazine for atherosclerosis in animal models: A systematic review and meta-analysis
Authors: Li SiJin , Liu Ping , Feng XiaoTeng , Wang YiRu , Du Min , Wang JiaRou 
Published: May 2022

Background
Atherosclerosis(AS) is widely recognized as a risk factor for incident cardiovascular and cerebrovascular diseases. Tetramethylpyrazine (TMP) is the active ingredient of Ligusticum wallichii that possesses a variety of biological activities against atherosclerosis.

Objective
This systematic review and meta-analysis sought to study the impact of and mechanism of tetramethylpyrazine for atherosclerosis in animal models.

Methods
A systematic search was conducted of PubMed, Embase, Cochrane Library, Web of Science database, Chinese Biomedical (CBM) database, China National Knowledge Infrastructure (CNKI), WanFang data, and Vip Journal Integration Platform, covering the period from the respective start date of each database to December 2021. We used SYRCLE’s 10-item checklist and Rev-Man 5.3 software to analyze the data and the risk of bias.

Results
Twelve studies, including 258 animals, met the inclusion criteria. Compared with the control group, TMP significantly reduced aortic atherosclerotic lesion area, and induced significant decreases in levels of TC (SMD = ‐2.67, 95% CI -3.68 to -1.67, P < 0.00001), TG (SMD = ‐2.43, 95% CI -3.39 to -1.47, P < 0.00001), and LDL-C (SMD = ‐2.87, 95% CI -4.16 to -1.58, P < 0.00001), as well as increasing HDL-C (SMD = 2.04, 95% CI 1.05 to 3.03, P = 0.001). TMP also significantly modulated plasma inflammatory responses and biological signals associated with atherosclerosis. In subgroup analysis, the groups of high-dose TMP (≥50 mg/kg) showed better results than those of the control group. No difference between various durations of treatment groups or various assessing location groups.

Conclusion
TMP exerts anti-atherosclerosis functions in an animal model of AS mediated by anti-inflammatory action, antioxidant action, ameliorating lipid metabolism disorder, protection of endothelial function, antiplatelet activity, reducing the proliferation and migration of smooth muscle cells, inhibition of angiogenesis, antiplatelet aggregation. Due to the limitations of the quantity and quality of current studies, the above conclusions need to be verified by more high-quality studies.

Trial registration number
PROSPERO registration no.CRD42021288874.
FINITE ELEMENT ANALYSIS OF MECHANICAL PROPERTIES OF SPECIMEN WITH UHPC AND STUD CONNECTOR
Authors: Liu Long , Wan Songqiang , Yao Shuwen , Zhao Xinzhen , Ma Jinyan 
Published: May 2022

UHPC is different from ordinary concrete for mechanical properties. To study the stress state of stud connector when UHPC is used to strengthen RC beam and its influence on bearing capacity of the strengthened beam, in this paper, ABAQUS was adopted first to simulate the push-out test of stud to verify accuracy of the finite element model. The nonlinearity of materials and contact conditions was considered in the model, and then three parameters including concrete strength, stud length and stud diameter were studied. Results showed the finite element model established by surface to surface contact method was possible to simulate the force and failure of the stud connector. UHPC could improve the bearing capacity of the stud specimens obviously, and the length of stud had little effect on bearing capacity of stud while failure of the stud may occur if length of the stud was too small. The increase of stud diameter could improve bearing capacity of elastic working stage.
All-optical ultrafast ReLU function for energy-efficient nanophotonic deep learning
Authors: Li Gordon H.Y. , Sekine Ryoto , Nehra Rajveer , Gray Robert M. , Ledezma Luis , Guo Qiushi , Marandi Alireza 
Published: May 2022

Abstract
In recent years, the computational demands of deep learning applications have necessitated the introduction of energy-efficient hardware accelerators. Optical neural networks are a promising option; however, thus far they have been largely limited by the lack of energy-efficient nonlinear optical functions. Here, we experimentally demonstrate an all-optical Rectified Linear Unit (ReLU), which is the most widely used nonlinear activation function for deep learning, using a periodically-poled thin-film lithium niobate nanophotonic waveguide and achieve ultra-low energies in the regime of femtojoules per activation with near-instantaneous operation. Our results provide a clear and practical path towards truly all-optical, energy-efficient nanophotonic deep learning.
The effects of high alkali impregnation and oxygen delignification of softwood kraft pulps on the yield and mechanical properties
Authors: Esteves Cláudia V. G. , Brännvall Elisabet , Östlund Sören , Sevastyanova Olena 
Published: May 2022

Abstract
This study investigated whether the yield improvement after high alkali impregnation (HAI) is maintained after oxygen delignification and whether the potential of oxygen delignification to increase the mechanical properties is affected by high alkali impregnation. The yield improvement achieved by high alkali impregnation (1 %) was preserved after oxygen delignification, particularly of glucomannan. The total fiber charge and swelling increased after oxygen delignification regardless of the type of impregnation in the cooking step. The tensile index improvement obtained by oxygen delignification was retained if this was preceded by high alkali impregnation. The stiffness index was higher and elongation slightly lower after HAI impregnation than after a standard (REF) impregnation. Fibers obtained through high alkali impregnation seem to be slightly less deformed and slightly wider than fibers obtained after a standard impregnation.
Healthy Lifestyle and Dietary Approaches to Treating Polycystic Ovary Syndrome: A Review
Authors: Zehravi Mehrukh , Maqbool Mudasir , Ara Irfat 
Published: May 2022

Abstract
PCOS (Polycystic Ovary Syndrome) is an endocrine condition that affects women of reproductive age: it can have catastrophic consequences, as it is accompanied by anovulation, androgen excess, infertility, insulin resistance, depression, and amenorrhea. Women who have a hereditary tendency are more likely to be affected. Other environmental variables such as a sedentary lifestyle, bad eating habits, inactivity, and obesity have frequently been implicated in the development of this illness. Each year, more women are diagnosed with PCOS as a result of an increasingly unhealthy lifestyle. When PCOS is detected early and treated correctly, the accompanying reproductive, metabolic, and cardiovascular problems can be effectively managed or predicted. PCOS is becoming a growing source of worry, as it primarily affects women of reproductive age. PCOS is also prevalent in many teenage girls during puberty. Despite being one of the most frequent reproductive health issues among women, doctors face a tremendous obstacle in providing appropriate medical therapy. PCOS is known to cause anxiety and despair, particularly when exacerbated by excessive facial hair growth, obesity, and infertility, anxiety and despair. Thus, PCOS can have a negative effect on an individual’s quality of life if it is not treated promptly. The best first-line treatment for PCOS is a lifestyle intervention that includes a healthy diet with caloric restriction, exercise to aid in weight loss and to avoid future weight gain, and support for behaviour modification. Future studies should focus on the gaps in our understanding of PCOS. Patients will receive the best care if those physicians are followed. To date, there has been no effective treatment for PCOS, and most patients receive only symptomatic treatment with hormones and insulin sensitizers, which leads to long-term medication dependency.
Conservative Therapy of Pressure Ulcers Using Physical Methods (Review)
Authors: Osmanov E. G. , Shulutko А. M. , Yakovlev A. A. , Krylov A. Y. , Yakovleva A. V. , Altuкhov E. L. , Gandybina E. G. , Martynov I. A. 
Published: May 2022

In Russia and European countries, the incidence of pressure (decubitus) ulcers in sedentary patients with severe comorbidities, spinal trauma, and cerebral accident sequelae varies from 3 to 40 %, reaching 80 % in the chronic critical illness. The final result of conservative treatment of pressure ulcers (PU) with adequate correction of comorbidities and proper care of the immobilized patient depends largely on the choice of local interventions. Aim of the review: to demonstrate the range of effective methods of physical treatment of pressure ulcers suitable for conservative treatment. Materials and methods. We selected and analyzed 80 scientific publications. Sources were selected from the PubMed, Scopus, and RSCI databases of medical and biological publications. The following methods were covered: negative pressure wound therapy, ultrasonic methods, hydrosurgical treatment, plasma flows, laser therapy (including low-level laser therapy), «hardware» acceleration of regenerative processes, including electrical stimulation, as well as a combination of these methods. Results. The variety of physical methods of wound treatment, on the one hand, provides an opportunity to select an individual therapy program. On the other hand, each method has its own limitations and contraindications. That is why in practice various combinations of these methods are reasonable. Conclusion. For several objective reasons, no reduction of PU incidence in clinical practice is expected. Therefore, studying the issues of evidence-based clinical effectiveness and economic feasibility of various conservative techniques of decubitus treatment to find best solutions in this area is warranted.
Experimental Study of Action Different Kinetic Energy on the Colon
Authors: Kvasnevskyi Yevhen , Kashtalian Michailo , Gerasimenko Oleh , Kvasnevskyi Oleksandr 
Published: May 2022

The purpose of the study. To increase the effectiveness of surgical care for the wounded with combat trauma of the colon by studying of ballistic, morphological and functional features of the gunshot wounds. Patients and methods. A study of surgical treatment of 83 wounded with combat injuries of the colon, received in the area of anti-terrorist operation in the period from 2014–2018. For comparative analysis of treatment results, two clinical groups were formed: comparison and main. The comparison group included 42 wounded who were treated from April 2014 to February 2015 (the first and second periods of ATO), who used traditional surgical tactics. The main group included 41 wounded who were treated from March 2015 to 2018. Results. Analysis of the distribution of wounded with combat trauma by type of wound / injury revealed that the vast majority of them in both groups had shrapnel wounds – 49 (59.1%). There were 30 (36.1%) victims with bullet wounds, and 4 (4.8%) with closed injuries. The wounded patients with the battle trauma of the thick bowel by type of injury had missile wounds as a rule – 49 (59.1%). There were 30 (36.1%) patients with bullet wounds, and 4 (4.8%) with closed injuries. Most of the injuries were combined – 58 (69.9%), and with only abdominal injuries – 25 (30.1%), mostly multiple – 21 (25.3%). The great majority of the thick bowel injuries belonged to sigmoid – 32 (38.6%) and transverse colon – 21 (25.3%), which is explained by relatively large size of these parts of the intestine. Conclusions. The choice of surgical tactics and scope of surgical interventions on damaged organs and structures took into account the results of experimental study of mechanogenesis and pathomorphology of gunshot wounds of the colon, obtained in bench studies by modeling gunshot wounds on “thoracoabdominal ballistic material”.
Building a Life Course Intervention Research Framework
Authors: Russ Shirley A. , Hotez Emily , Berghaus Mary , Hoover Clarissa , Verbiest Sarah , Schor Edward L. , Halfon Neal 
Published: May 2022

OBJECTIVES
To report on first steps toward building a Life Course Intervention Research Framework (LCIRF) to guide researchers studying interventions to improve lifelong health.

METHODS
The Life Course Intervention Research Network, a collaborative national network of &gt;75 researchers, service providers, community representatives and thought leaders, participated in an iterative review process. Building on the revised Medical Research Council Guidance for Developing and Evaluating Complex Interventions, they identified 12 additional key models with features for inclusion in the LCIRF, then incorporated the 12 characteristics identified by the Life Course Intervention Research Network as actionable features of Life Course Interventions to produce the new LCIRF.

RESULTS
The LCIRF sets out a detailed step-wise approach to intervention development: (1) conceptualization and planning, (2) design, (3) implementation, (4) evaluation, and (5) spreading and scaling of interventions. Each step is infused with life course intervention characteristics including a focus on (1) collaborative codesign (2) health optimization, (3) supporting emerging health development capabilities (4) strategic timing, (5) multilevel approaches, and (6) health equity. Key features include a detailed transdisciplinary knowledge synthesis to inform intervention development; formation of strong partnerships with family, community, and youth representatives in intervention codesign; a means of testing the impact of each intervention on biobehavioral processes underlying emerging health trajectories; and close attention to intervention context.

CONCLUSIONS
This first iteration of the LCIRF has been largely expert driven. Next steps will involve widespread partner engagement in framework refinement and further development. Implementation will require changes to the way intervention studies are organized and funded.