bluuebunny/crossref_metadata_2025_split huggingface dataset:
High B-value diffusion tensor imaging for early detection of hippocampal microstructural alteration in a mouse model of multiple sclerosis
Authors: Crombé Amandine , Nicolas Renaud , Richard Nathalie , Tourdias Thomas , Hiba Bassem 
Published: July 2022

AbstractSeveral studies have highlighted the value of diffusion tensor imaging (DTI) with strong diffusion weighting to reveal white matter microstructural lesions, but data in gray matter (GM) remains scarce. Herein, the effects of b-values combined with different numbers of diffusion-encoding directions (NDIRs) on DTI metrics to capture the normal hippocampal microstructure and its early alterations were investigated in a mouse model of multiple sclerosis (experimental autoimmune encephalomyelitis [EAE]). Two initial DTI datasets (B2700-43Dir acquired with b = 2700 s.mm−2 and NDIR = 43; B1000-22Dir acquired with b = 1000 s.mm−2 and NDIR = 22) were collected from 18 normal and 18 EAE mice at 4.7 T. Three additional datasets (B2700-22Dir, B2700-12Dir and B1000-12Dir) were extracted from the initial datasets. In healthy mice, we found a significant influence of b-values and NDIR on all DTI metrics. Confronting unsupervised hippocampal layers classification to the true anatomical classification highlighted the remarkable discrimination of the molecular layer with B2700-43Dir compared with the other datasets. Only DTI from the B2700 datasets captured the dendritic loss occurring in the molecular layer of EAE mice. Our findings stress the needs for both high b-values and sufficient NDIR to achieve a GM DTI with more biologically meaningful correlations, though DTI-metrics should be interpreted with caution in these settings.
Measurement precision of the Pain Catastrophizing Scale and its short forms in chronic low back pain
Authors: Franchignoni Franco , Giordano Andrea , Ferriero Giorgio , Monticone Marco 
Published: July 2022

AbstractThe Pain Catastrophizing Scale (PCS) is a widely studied tool to assess pain catastrophizing for chronic low back pain (LBP). Short forms of the PCS exist, but their measurement precision at individual level is unclear. This study aimed to analyze the Rasch psychometric characteristics of the PCS and three of its short forms (two 4-item and one 6-item) in a sample of 180 Italian-speaking patients with chronic LBP, and compare their measurement precision at the individual level. We performed a Rasch analysis on each version of the PCS and calculated test information functions (TIFs) to examine conditional measurement precision. Rasch analysis showed appropriate rating category functioning, unidimensionality, and acceptable fit to the Rasch model for all PCS versions. This represented a prerequisite for performing further advanced psychometric analyses. According to TIFs, the PCS full scale showed—at any score level—higher measurement precision in estimating individual pain catastrophizing than its short forms (which had unacceptably high standard errors of measurement). Our results show acceptable conditional precision of the PCS full scale in estimating pain catastrophizing. However, further studies are needed to confirm its diagnostic accuracy at individual level. On the other hand, the study warns against use of the three PCS short forms for clinical decision-making at the individual level.
Dynamical links of convective storms associated with tropospheric biennial oscillation in the Indian monsoon regime
Authors: Murali Krishna U. V. , Das Subrata Kumar , Uma K. N. , Jha Abhishek Kumar , Pandithurai G. 
Published: July 2022

AbstractTropospheric Biennial Oscillation (TBO) is characterized by a tendency for a relatively stronger monsoon to be followed by a relatively weaker one (positive) or vice-versa (negative). This study examines the distribution of different convective systems occurring during TBO phases over the Indian monsoon region. During negative TBO phase, convection is preferential over the Arabian Sea (AS), whereas during positive TBO phase, it is favoured over the land areas and Bay of Bengal (BoB). The isolated shallow convection (ISC) is dominated over the AS and Indian west coast during negative TBO years. A relatively stable environment (statically) capped with drier mid-troposphere results in abundant ISC over the AS. Broad stratiform rain (BSR) dominates over the central and east coast of India, BoB and Myanmar coast during positive TBO years and wide convective core (WCC) are present along the orographic regions, i.e., Myanmar coast and Western Ghats during negative TBO phase. The anomalous easterlies induced by the upper-ocean temperature gradient interact with the mean monsoon winds during positive TBO to provide pathways for developing BSR echoes. The deep-wide convection (DWC) are higher along the Himalayan foothills during positive TBO years. The moist low-level flow from the AS is trapped by dry mid-level flow from high latitudes, resulting in orographic lifting along the Himalayan foothills and form DWC.
Reduced heart rate variability is related to the number of metabolic syndrome components and manifest diabetes in the sixth Tromsø study 2007–2008
Authors: Azulay Naomi , Olsen Roy Bjørkholt , Nielsen Christopher Sivert , Stubhaug Audun , Jenssen Trond Geir , Schirmer Henrik , Frigessi Arnoldo , Rosseland Leiv Arne , Tronstad Christian 
Published: July 2022

AbstractBoth diabetes mellitus (DM) and the metabolic syndrome (MetS) are associated with autonomic neuropathy, which predisposes to cardiac events and death. Measures of heart rate variability (HRV) can be used to monitor the activity of the autonomic nervous system (ANS), and there are strong indications that HRV can be used to study the progression of ANS-related diabetes complications. This study aims to investigate differences in HRV in healthy, MetS and diabetic populations. Based on 7880 participants from the sixth health survey in Tromsø (Tromsø 6, 2007–2008), we found a significant negative association between the number of MetS components and HRV as estimated from short-term pulse wave signals (PRV). This decrease in PRV did not appear to be linear, instead it leveled off after the third component, with no significant difference in PRV between the MetS and DM populations. There was a significant negative association between HbA1c and PRV, showing a decrease in PRV occurring already within the normal HbA1c range. The MetS and DM populations are different from healthy controls with respect to PRV, indicating impaired ANS in both conditions. In the future, a study with assessment of PRV measurements in relation to prospective cardiovascular events seems justified.
Nutritional support for successful weaning in patients undergoing prolonged mechanical ventilation
Authors: Lo Shih-Ching , Ma Kevin Sheng-Kai , Li Yen-Ru , Li Zi-Yue , Lin Cheng-Hung , Lin Hsing-Chun , Yang Shun-Fa 
Published: July 2022

AbstractSuccessful weaning from ventilators not only improves the quality of life of patients, but also reduces medical expenses. The aim of this study was to explore the association between nutritional provision and successful ventilator weaning. In this retrospective study data from the Respiratory Care Center of Chung Shan Medical University Hospital between October, 2017 and July, 2019 on patient characteristics, amount of nutrition delivered, and clinical outcomes were retrieved. A total of 280 ventilated patients were enrolled and divided into successful extubation and failed weaning groups. There were 178 males (63.6%) and 102 females (36.4%) with a mean age of 67.3 ± 16.9 years. The successful extubation group consisted of patients who tended towards ideal body weight during the weaning process (BMI 23.9 ± 5.0 versus 22.7 ± 4.8 kg/m2, p < 0.001). Patients from both groups initially received the same nutritional intervention, while patients of successful extubation received significantly more calories and protein after weaning (23.8 ± 7.8 kcal versus 27.8 ± 9.1 kcal, p < 0.001 and 0.97 ± 0.36 g versus 1.14 ± 0.42 g, p < 0.001). Successful weaning was associated with higher survival rate (p = 0.016), shortened hospital stay (p = 0.001), and reduced medical costs (p < 0.001). Overall, nutritional support with high calories and protein was associated with the probability of successful ventilator weaning in patients undergoing prolonged mechanical ventilation. Adequate nutrition is a determinant of successful ventilator weaning.
Double-mode and double-beam staggered double-vane traveling-wave tube with high-power and broadband at terahertz band
Authors: Wang Wenbo , Zhang Zheng , Wang Pengpeng , Zhao Yaqi , Zhang Feng , Ruan Cunjun 
Published: July 2022

AbstractIn this paper, a 220 GHz broadband and high-power staggered double-vane traveling-wave tube has been designed and verified. Firstly, a planar double-beam staggered double-vane slow-wave structure is proposed. By using the double-mode operation scheme, the transmission performance and bandwidth have been almost increased with twice as the single mode. Second, to satisfy the high output power requirement and improve the stability of the traveling-wave tube, a double pencil-beam electron optical system has been designed, the 20–21 kV driven voltage and the 2 × 80 mA current are set as the design target. By using the mask portion and the control electrode in the double beam gun, the two pencil beams can be focused with a compression ratio of 7 along their respective centers with narrow distances of about 0.18 mm with good stability. The uniform magnetic focusing system has also been optimized. The stable transmission distance of planar double electron beams could reach 45 mm with the focusing magnetic field of 0.6 T, which was long enough to cover the whole high-frequency system (HFS). Then, to verify the availability of the electron optical system and the performance of the slow-wave structure, particle-in-cell (PIC) simulation has also been carried out with the whole HFS. Results demonstrate that the beam-wave interaction system can get a nearly 310 W peak output power at 220 GHz with a 20.6 kV optimized beam voltage and beam current of 2 × 80 mA, the gain is of 38 dB with the 3-dB bandwidth over 35 dB about 70 GHz. Finally, the high precision microstructures fabrication has been carried out to verify the performance of the HFS, the results show that the bandwidth and the transmission properties are in good agreement with simulation result. Thus, the proposed scheme in this paper is expected to develop the high-power and ultra-wideband terahertz band radiation source with potential applications in the future.
Linear and nonlinear thermoelectric transport in a quantum spin Hall insulators coupled with a nanomagnet
Authors: Wang Rui , Liao Hui , Song Chun-Yan , Tang Guang-Hui , Yang Ning-Xuan 
Published: July 2022

AbstractThermoelectric effects in quantum systems have been focused in recent years. Thermoelectric energy conversion study of systems with edge states, such as quantum Hall insulators and quantum spin Hall insulators, is one of the most important frontier topics in material science and condensed-matter physics. Based on the previous paper (Gresta in Phys Rev Lett 123:186801, 2019), we further investigated the linear and nonlinear thermoelectric transport properties of helical edge states of the quantum spin Hall insulators coupled with double nanomagnet, calculated the Seebeck coefficients $$S_c$$

S
c

and the thermoelectrical figure of merit ZT, discussed the influence of the length of the nanomagnet and the relative tilt angle of component of the magnetization perpendicular on the thermoelectric coefficients ($$S_c$$

S
c

and ZT), and summarized some meaningful conclusions in the linear response regime. In the nonlinear regime, we calculated the equivalent figure of merit $$ZT_M$$

Z

T
M

and the power-generation efficiency $$\eta$$
η
in different length of the nanomagnet, obtain the temperature difference of achieving optimal thermoelectricity. The results of this paper further confirm that the setup can indeed be used as a device for achieving high performance thermoelectric.
Electrochemical detection of uric acid in undiluted human saliva using uricase paper integrated electrodes
Authors: Han Seong Hyun , Ha You-Jung , Kang Eun Ha , Shin Kichul , Lee Yun Jong , Lee Gi-Ja 
Published: July 2022

AbstractIn this study, we introduce a uricase-immobilized paper (UOx­-paper) integrated electrochemical sensor for detection of uric acid (UA) in saliva. The UOx was immobilized on the detection zone in the wax-patterned paper substrate. This UOx-paper was integrated with a Prussian blue­-modified, screen-printed carbon electrode after electropolymerization of o-phenylenediamine to construct an electrochemical cell for small-volume (20 μL) of samples. First, we optimized the fabrication conditions of UOx-paper. Next, the amperometric response of the UOx-paper-based electrochemical UA sensor was analyzed using a known concentration of UA standard solution in artificial saliva at an applied potential of − 0.1 V (versus Ag pseudo-reference electrode). The UOx-­paper based electrochemical UA sensor showed a sensitivity of 4.9 μA·mM−1 in a linear range of 50 to 1000 μM (R2 = 0.998), high selectivity and good reproducibility, as well as a limit of detection of 18.7 μM (0.31 mg/dL) UA. Finally, we quantified the UA levels in undiluted saliva samples of healthy controls (n = 20) and gout patients (n = 8). The levels were correlated with those measured with conventional salivary UA enzymatic assays as well as serum UA levels. The UOx-paper-based electrochemical UA sensor is a user-friendly and convenient tool to assess salivary UA levels.
Simultaneous measurement of energy spectrum and fluence of neutrons using a diamond detector
Authors: Liu Jie , Jiang Haoyu , Cui Zengqi , Hu Yiwei , Bai Haofan , Fan Tieshuan , Chen Jinxiang , Gao Yuan , Yang Xiangjun , Zhang Guohui 
Published: July 2022

AbstractDue to the excellent radiation hardness and high–temperature endurance, diamond detectors are suitable for intense neutron measurements and promising for neutron diagnostics of scientific fusion devices. In the present work, simultaneous measurement of energy spectrum and fluence of neutrons using a diamond detector was realized for the first time. The absolute response matrix of the diamond detector was simulated based on detailed analysis of the nuclear reactions and the proper selection of nuclear reaction data. Neutron energy spectra as well as neutron fluences for 5.0, 5.5, 8.5, 9.5 and 10.5 MeV neutrons from d–d reaction were measured using the diamond detector based on the absolute response matrix. The measured neutron energy spectra and neutron fluences are reasonable compared with those detected using a EJ-309 liquid scintillator and a 238U fission chamber, respectively, which verifies the reliability of the present work. Furthermore, the energy spectrum and fluence of a 14.2 MeV d–t neutron source were also measured using the diamond detector. The present work demonstrates the ability of simultaneous measurement of energy spectrum and fluence as well as for both d–d and d–t neutrons using a diamond detector, which is of great significance for neutron diagnostics of scientific fusion devices.
The rise of Indian summer monsoon precipitation extremes and its correlation with long-term changes of climate and anthropogenic factors
Authors: Falga Renaud , Wang Chien 
Published: July 2022

AbstractThe trends of extreme precipitation events during the Indian summer monsoon measured by two different indicators have been analyzed for the period of 1901–2020, covering the entire India in 9 regions segregated by a clustering analysis based on rainfall characteristics using the Indian Meteorological Department high-resolution gridded data. In seven regions with sufficiently high confidence in the precipitation data, 12 out of the 14 calculated trends are found to be statistically significantly increasing. The important climatological parameters correlated to such increasing trends have also been identified by performing for the first time a multivariate analysis using a nonlinear machine learning regression with 17 input variables. It is found that man-made long-term shifting of land-use and land-cover patterns, and most significantly the urbanization, play a crucial role in the prediction of the long-term trends of extreme precipitation events, particularly of the intensity of extremes. While in certain regions, thermodynamical, circulation, and convective instability parameters are also found to be key predicting factors, mostly of the frequency of the precipitation extremes. The findings of these correlations to the monsoonal precipitation extremes provides a foundation for further causal relation analyses using advanced models.
Design, characterization and structure–function analysis of novel antimicrobial peptides based on the N-terminal CATH-2 fragment
Authors: Sharma Pratibha , Sharma Sheetal , Joshi Shubhi , Barman Panchali , Bhatt Aashish , Maan Mayank , Singla Neha , Rishi Praveen , Ali Md. Ehesan , Preet Simran , Saini Avneet 
Published: July 2022

AbstractThe emergence of multidrug resistance coupled with shrinking antibiotic pipelines has increased the demand of antimicrobials with novel mechanisms of action. Therefore, researchers across the globe are striving to develop new antimicrobial substances to alleviate the pressure on conventional antibiotic therapies. Host-Defence Peptides (HDPs) and their derivatives are emerging as effective therapeutic agents against microbial resistance. In this study, five analogs (DP1-5) of the N-terminal (N-15) fragment of CATH-2 were designed based on the delicate balance between various physicochemical properties such as charge, aliphatic character, amphipathicity and hydrophobicity. By means of in-silico and in-vitro studies a novel peptide (DP1) with the sequence “RFGRFLRKILRFLKK” was found to be more effective and less toxic than the N-terminal CATH-2 peptide. Circular dichroism spectroscopy and differential scanning calorimetry were applied for structural insights. Antimicrobial, haemolytic, and cytotoxic activities were also assessed. The resulting peptide was characterized by low cytotoxicity, low haemolytic activity, and efficient anti-microbial activity. Structurally, it displayed strong helical properties irrespective of the solvent environment and was stable in membrane-mimicking environments. Taken together, the data suggests that DP1 can be explored as a promising therapeutic agent with possible clinical applications.
Towards 3D basic theories of plant forms
Authors: Lin Yi , Hyyppä Juha 
Published: July 2022

AbstractAllometric, metabolic, and biomechanical theories are the critical foundations for scientifically deciphering plant forms. Their concrete laws, however, are found to deviate for plenty of plant specimens. This phenomenon has not been extensively studied, due to technical restrictions. This bottleneck now can be overcome by the state-of-the-art three-dimensional (3D) mapping technologies, such as fine-scale terrestrial laser scanning. On these grounds, we proposed to reexamine the basic theories regarding plant forms, and then, we case validated the feasibility of upgrading them into 3D modes. As an in-time enlightening of 3D revolutionizing the related basic subject, our theoretical prospect further sorted out the potential challenges as the cutting points for advancing its future exploration, which may enable 3D reconstruction of the basic theories of plant forms and even boost life science.
Mitochondrial prohibitin complex regulates fungal virulence via ATG24-assisted mitophagy
Authors: Yan Yaqin , Tang Jintian , Yuan Qinfeng , Liu Caiyun , Chen Xiaolin , Liu Hao , Huang Junbin , Bao Chonglai , Hsiang Tom , Zheng Lu 
Published: July 2022

AbstractProhibitins are highly conserved eukaryotic proteins in mitochondria that function in various cellular processes. The roles of prohibitins in fungal virulence and their regulatory mechanisms are still unknown. Here, we identified the prohibitins ChPhb1 and ChPhb2 in a plant pathogenic fungus Colletotrichum higginsianum and investigated their roles in the virulence of this anthracnose fungus attacking crucifers. We demonstrate that ChPhb1 and ChPhb2 are required for the proper functioning of mitochondria, mitophagy and virulence. ChPhb1 and ChPhb2 interact with the autophagy-related protein ChATG24 in mitochondria, and ChATG24 shares similar functions with these proteins in mitophagy and virulence, suggesting that ChATG24 is involved in prohibitin-dependent mitophagy. ChPhb1 and ChPhb2 modulate the translocation of ChATG24 into mitochondria during mitophagy. The role of ChATG24 in mitophagy is further confirmed to be conserved in plant pathogenic fungi. Our study presents that prohibitins regulate fungal virulence by mediating ATG24-assisted mitophagy.
Classifying soft self-assembled materials via unsupervised machine learning of defects
Authors: Gardin Andrea , Perego Claudio , Doni Giovanni , Pavan Giovanni M. 
Published: July 2022

AbstractUnlike molecular crystals, soft self-assembled fibers, micelles, vesicles, etc., exhibit a certain order in the arrangement of their constitutive monomers but also high structural dynamicity and variability. Defects and disordered local domains that continuously form-and-repair in their structures impart to such materials unique adaptive and dynamical properties, which make them, e.g., capable to communicate with each other. However, objective criteria to compare such complex dynamical features and to classify soft supramolecular materials are non-trivial to attain. Here we show a data-driven workflow allowing us to achieve this goal. Building on unsupervised clustering of Smooth Overlap of Atomic Position (SOAP) data obtained from equilibrium molecular dynamics simulations, we can compare a variety of soft supramolecular assemblies via a robust SOAP metric. This provides us with a data-driven “defectometer” to classify different types of supramolecular materials based on the structural dynamics of the ordered/disordered local molecular environments that statistically emerge within them.