bluuebunny/crossref_metadata_2025_split huggingface dataset:
A right pulmonary vein abnormality treated with 3D CT assistance in thoracoscopic surgery for esophageal cancer: a case report
Authors: Kuwayama Naoki , Hoshino Isamu , Gunji Hisashi , Tonooka Toru , Soda Hiroaki , Kurosaki Takeshi , Takiguchi Nobuhiro , Nabeya Yoshihiro , Takayama Wataru 
Published: March 2022

Abstract
Background
Anomalous bifurcation of the right superior pulmonary vein is an important anomaly that should be recognized not only in respiratory and cardiac surgeries, but also in esophageal surgery for the safe performance of surgery. We report a case in which thoracoscopic esophagectomy was safely performed using preoperative three-dimensional computed tomography (3D CT) imaging.

Case presentation
An 81-year-old male patient received an upper gastrointestinal endoscopy, which revealed a 20-cm incisor at the entrance, 43-cm EGJ, and 30-mm large type 1 + IIc lesion between the 23-cm and 26-cm incisors; biopsy showed squamous cell carcinoma (SCC). Contrast-enhanced CT showed wall thickening in the anterior wall of the upper thoracic esophagus, without evidence of multi-organ invasion or lymph node metastasis. In addition, a break in the right pulmonary vein passing dorsal to the right main bronchus and flowing directly into the left atrium was observed, and 3D CT was performed preoperatively to confirm the 3D positioning. Positron emission tomography (PET)–CT showed a high degree of accumulation (SUVmax 19.95) in the upper thoracic esophagus. The patient was diagnosed with upper thoracic esophageal cancer, cT2N0M0 cStage II, and underwent thoracoscopic subtotal esophagectomy (three-region dissection) and gastric tube reconstruction. The dorsal inflow of the pulmonary vein in the right main bronchus, which was recognized on preoperative CT, was confirmed and preserved. The pathological diagnosis was basaloid squamous cell carcinoma, pT1b(SM1)N0(0/58)M0 pStage I. The postoperative course was uneventful, and the patient was discharged on postoperative day 20.

Conclusions
The anomalous bifurcation of the pulmonary vein in the right upper lobe area required attention because of its potential to cause massive bleeding and difficulty in securing the operative field if misidentified and damaged during surgery. Although it is not frequently encountered, it is the bifurcation anomaly that esophageal surgeons must bear in mind due to its severe consequences. Preoperative image-reading and intraoperative manipulation of this vessel are imperative for surgical safety.
Hyperinsulinemic hypoglycemia in adolescents: case report and systematic review
Authors: Castillo-López M. G. , Fernandez M. F. , Sforza N. , Barbás N. C. , Pattin F. , Mendez G. , Ogresta F. , Gondolesi I. , Barros Schelotto P. , Musso C. , Gondolesi G. E. 
Published: March 2022

AbstractBackgroundHyperinsulinemic hypoglycemia is the most common cause of severe and persistent hypoglycemia in neonates and children. It is a heterogeneous condition with dysregulated insulin secretion, which persists in the presence of low blood glucose levels.Case presentationWe report a case of a 15 year-old male with hyperinsulinemic hypoglycemia, who underwent a subtotal pancreatectomy after inadequate response to medical therapy. Pathological examination was positive for nesidioblastosis (diffuse β-cell hyperplasia by H-E and immunohistochemical techniques). The patient’s blood glucose levels normalized after surgery and he remains asymptomatic after 1 year of follow-up. The systematic review allowed us to identify 41 adolescents from a total of 205 cases reported in 22 manuscripts, from a total of 454 found in the original search done in PubMed and Lilacs.ConclusionsAlthough very well reported in children, hyperinsulinemic hypoglycemia can occur in adolescents or young adults, as it happens in our reported case. These patients can be seen, treated and reported by pediatricians or adult teams either way due to the wide age range used to define adolescence. Most of them do not respond to medical treatment, and subtotal distal pancreatectomy has become the elected procedure with excellent long-term response in the vast majority.
Assessing parents’ self-efficacy to handle child obesity-related behaviors: validation of the Lifestyle Behavior Checklist in Iran
Authors: Omidvar Nasrin , Narmcheshm Saba , Eini-Zinab Hassan , Amiri Parisa , Sobhani Sayyed Reza , Doustmohammadian Azam 
Published: March 2022

Abstract
Background
The aim of the present study was to validate the Lifestyle Behavior Checklist (LBC) questionnaire, to measure Iranian parents' perceptions of their children's weight-related behaviors and their self-efficacy in dealing with those behaviors.

Methods
The LBC was translated into Farsi. Face and content validity of the questionnaire was evaluated by an expert panel. A total of 213 mothers of 3–12-year-old children responded to the questionnaire. Criterion validity of the questionnaire was evaluated through comparing its result with a parenting style questionnaire. Principal component analysis (PCA) and confirmatory factor analyses (CFA) were used to evaluate construct validity of the questionnaire. Reproducibility was measured by twice administration of LBC, one month apart and using Spearman's rho correlation test. The questionnaire's internal consistency was assessed by calculating Cronbach's α.

Results
LBC Problem scale was significantly correlated with authoritarian parenting style score, while the Confidence scale was significantly correlated with authoritative and negatively with permissive and authoritarian parenting styles. PCA suggested a six-factor construct, including, fussy eating, food-related problem behaviors, overeating behaviors, low interest in physical activity, poor self-image and sedentary behaviors. The results of CFA indicated acceptable fit indices for the proposed models. Both, Problem scale (Cronbach's α = 0.8) and Confidence scale (Cronbach's α = 0.95) had high internal consistency. Spearman correlation coefficients indicated acceptable reproducibility for both the Problem scale (r = 0.74) and the Confidence scale (r = 0.70).

Conclusions
The Farsi version of LBC questionnaire is reliable and reasonably valid to measure Iranian mothers' perception of their children's weight-related problem behavior.
Prognostic value of patient-reported outcome measures in adult heart-transplant patients: a systematic review
Authors: Villa Bernardo Perez , Alotaibi Sultan , Brozzi Nicolas , Spindler Kurt P. , Navia Jose , Hernandez-Montfort Jaime 
Published: March 2022

Abstract
Background
The aim of this systematic review was to describe the prognostic value of patient-reported outcome measures (PROMs) in adult heart-transplant (HT) patients.

Methods
A systematic search was performed on Ovid Medline, CINAHL Plus, Web of Science, and PubMed. The study protocol was registered on the PROSPERO database (CRD42021225398), and the last search was performed on January 7, 2021. We included studies of adult HT patients where generic and disease-specific PROMs were used as prognostic indicators for survival, readmissions, HT complications, and the onset of new comorbidities. We excluded studies that used clinician-reported and patient-experience outcomes. The Quality in Prognosis Studies tool (QUIPS) was used to measure the risk of bias of the included studies.

Results
We included five observational studies between 1987 and 2015, whose populations’ mean age ranged from 43 to 56 years and presented a higher proportion of males than females. The Kansas City Cardiomyopathy Questionnaire demonstrated a negative correlation with readmissions (coefficient = − 1.177, p = 0.031), and the EQ-5D showed a negative correlation with the onset of neuromuscular disease after HT (coefficient = − 0.158, p < 0.001). The Millon Behavioral Health Inventory and the Nottingham Health Profile demonstrated a statistically significant association as survival predictors (p = 0.002 and p < 0.05, respectively). A moderate overall risk of bias was reported in three studies, one study resulted in a low risk of bias, and a proportion of more than 75% of males in each of the studies. High heterogeneity between the studies impeded establishing a link between PROMs and prognostic value.

Conclusion
There is low evidence supporting PROMs usage as prognostic tools in adult HT patients. Comparing outcomes of PROMS to routine prognostic in wider and systematic settings is warranted. Systematic use of PROMs in clinical settings is warranted.
Rare cause of duodenal obstruction in a young-age female: a case report
Authors: Tag-Adeen Mohammed , Abdellatif Abeer Awad , Kamel Ahmed Hosni , Alboraie Mohamed 
Published: March 2022

Abstract
Background
Gastrointestinal tract can be compressed by many vascular structures in the abdomen; such compressions may be incidentally found or may result in compression symptoms like abdominal pain and vomiting.

Case presentation
We illustrate an uncommon cause of extrinsic compression of the third part of the duodenum by jejunal branches of the superior mesenteric artery in an 18-year-old female, presented with dull-aching epigastric pain and vomiting. Contrast Enhanced Computerized Tomography (CECT) showed atypical origin of the jejunal branches of superior mesenteric artery with relative space narrowing between it and the aorta, causing significant compression on the third part of the duodenum. Barium follow-through confirmed indentation of the duodenal lumen at the same level of the aberrant vessel. Conservative treatment failed to control her symptoms, and the patient referred to the surgery.

Conclusion
High index of suspicion is required for diagnosis of atypical causes of upper abdominal pain and vomiting. CECT guided by a well-descriptive comment of the treating doctor is very helpful diagnostic tool for detecting such rare condition. Barium studies still have a valuable role for determining the level of obstruction and confirming the diagnosis of such rare cases.
Influence of COVID-19 pandemic lockdown on a sample of Egyptian children with Down syndrome
Authors: Meguid Nagwa A. , Nashaat Neveen Hassan , Abdallah Hanaa Reyad , Hemimi Maha , Elnahry Ahmed , El-Hariri Hazem Mohamed , Elsaeid Amal 
Published: March 2022

Abstract
Background
Down syndrome (DS) is characterized by variable degrees of intellectual disability (ID). The coronavirus disease-2019 (COVID-19) lockdown prevented children with DS from reaching their rehabilitation facilities. This could have led to deterioration of their abilities and mental health hazards. The aim of this cohort study was to investigate frequency of COVID-19, the influence of COVID-19 pandemic on health, and some abilities of children with DS, and to explore factors that could have governed receiving home-based training during the lockdown. A survey of 150 individuals with Down syndrome was answered by their caregivers. Additionally, 135 participants were subjected to assessment of cognitive, language, and motor abilities using Portage program. They were divided into 2 groups: group I who received online therapy sessions during the lockdown and group II who did not receive sessions. Logistic regression was used to determine the factors which influenced getting home-based training.

Results
The percentage of COVID-19 cases was 3.3%. All evaluated abilities were reduced despite receiving online sessions particularly language performance (P < 0.001). Male gender, having severe ID and low parental education were among the factors which encouraged parents to get virtual training.

Conclusion
COVID-19 pandemic had a negative impact on the abilities of DS children even those who got rehabilitation sessions. Their dependence on social interaction could have limited the benefit of virtual sessions. Factors that influence a parent’s decision to get home-based training should be monitored and targeted in order to overcome obstacles or concepts that may prevent families from enduring home-based intervention.
Investigation of miR-222 as a potential biomarker in diagnosis of patients with methamphetamine abuse disorder
Authors: Fathi Shima , Soltanzadeh Hossein , Tanomand Asghar , Asadi Zahra , Rezai Moradali Saman 
Published: March 2022

AbstractBackgroundMethamphetamine abuse disorder is an important social and health problem worldwide. Diagnosis and confirmation of patients with methamphetamine abuse using serum are important in many fields. MicroRNAs (miRNAs) are small non-coding oligonucleotides and recently suggested as a biomarker for earlier diagnosis of several human disorders. Therefore, in this study, we investigated miR-222 and miR-212 expressions in blood of patients with methamphetamine abuse disorder comparison with healthy control subjects.ResultsThe results revealed that the expression of blood miR-222 is significantly increased (12.9-fold change) in patients with methamphetamine abuse disorders compared to healthy controls (p < 0.05). However, expression of miR-212 is at the same levels in both patients and healthy controls (p > 0.05).ConclusionsIn general, we suggested that the miR-222 may play a potentially important role in pathogenesis of methamphetamine abuse disorder and can be considered as an applied tool for identifying individuals with methamphetamine abuse disorder.
Lack of Concordance in Symptomatic Adverse Event Reporting by Children, Clinicians, and Caregivers: Implications for Cancer Clinical Trials
Authors: Freyer David R. , Lin Li , Mack Jennifer W. , Maurer Scott H. , McFatrich Molly , Baker Justin N. , Jacobs Shana S. , Lucas Nicole , Withycombe Janice S. , Tomlinson Deborah , Villabroza Katie Rose , Waldron Mia K. , Hinds Pamela S. , Reeve Bryce B. 
Published: March 2022

PURPOSE To examine concordance in symptomatic adverse event (AE) grading using the Common Terminology Criteria for Adverse Events (CTCAE 4.0) for clinicians and its patient-reported outcome (PRO) versions for children (Ped-PRO-CTCAE) and caregivers (Ped-PRO-CTCAE [Caregiver]). METHODS Children age 7-18 years with a first cancer diagnosis, their clinicians, and caregivers completed CTCAE-based measures before starting a treatment course (T1) and after the treatment (T2). Grades (0-3) were assigned by each reporter for 15 core AEs spanning physical and mental health. Mean grades were compared between reporters using two-sample t-tests; agreement was estimated using weighted kappa (κ) statistics. Multivariable mixed regression models were used to evaluate associations of clinical factors with AE reporting concordance. Significance was set at α = .05 (two-sided). RESULTS There were 438 child-clinician-caregiver triads with complete data at either T1 or T2. For children, the mean age was 13 years (standard deviation = 3.4), 53.7% were male, 32.6% non-White, and 56.4% had leukemia/lymphoma. At T1, clinician mean AE grades were significantly lower (ie, better) than children for all AEs and remained significantly lower at T2 except for constipation, nausea, anorexia, neuropathy, and anxiety. Caregiver mean AE grades were similar to children at T1 and significantly higher (ie, worse) at T2 for nausea, vomiting, anorexia, pain, fatigue, anxiety, and depression. Agreement for child-clinician grading was poor-to-fair at T1 (κ range, 0.08-0.34) and T2 (0.11-0.35), and for child-caregiver, was fair-to-good at T1 (0.34-0.65) and T2 (0.24-0.60). No factors were consistently associated with reporter concordance across AEs. CONCLUSION Compared with children, symptomatic AEs were consistently under-reported by clinicians with low agreement and over-reported by caregivers with low-moderate agreement. Direct reporting by children using Ped-PRO-CTCAE or similar measures should be routinely incorporated for toxicity assessment in clinical trials.
Safety, Feasibility, and Merits of Longitudinal Molecular Testing of Multiple Metastatic Sites to Inform mTNBC Patient Treatment in the Intensive Trial of Omics in Cancer
Authors: Burton Kimberly A. , Mahen Elisabeth , Konnick Eric Quentin , Blau Sibel , Dorschner Michael O. , Ramirez Arturo B. , Schmechel Stephen C. , Song Chaozhong , Parulkar Rahul , Parker Stephanie , Senecal Francis Mark , Pritchard Colin C. , Mecham Brigham H. , Szeto Christopher , Spilman Patricia , Zhu Jingchun , Gadi Vijayakrishna K. , Ronen Roy , Stilwell Jackie , Kaldjian Eric , Dutkowski Janusz , Benz Stephen Charles , Rabizadeh Shahrooz , Soon-Shiong Patrick , Blau C. Anthony 
Published: March 2022

PURPOSE Patients with metastatic triple-negative breast cancer (mTNBC) have poor outcomes. The Intensive Trial of Omics in Cancer (ITOMIC) sought to determine the feasibility and potential efficacy of informing treatment decisions through multiple biopsies of mTNBC deposits longitudinally over time, accompanied by analysis using a distributed network of experts. METHODS Thirty-one subjects were enrolled and 432 postenrollment biopsies performed (clinical and study-directed) of which 332 were study-directed. Molecular profiling included whole-genome sequencing or whole-exome sequencing, cancer-associated gene panel sequencing, RNA-sequencing, and immunohistochemistry. To afford time for analysis, subjects were initially treated with cisplatin (19 subjects), or another treatment they had not received previously. The results were discussed at a multi-institutional ITOMIC Tumor Board, and a report transmitted to the subject's oncologist who arrived at the final treatment decision in conjunction with the subject. Assistance was provided to access treatments that were predicted to be effective. RESULTS Multiple biopsies in single settings and over time were safe, and comprehensive analysis was feasible. Two subjects were found to have lung cancer, one had carcinoma of unknown primary site, tumor samples from three subjects were estrogen receptor–positive and from two others, human epidermal growth factor receptor 2–positive. Two subjects withdrew. Thirty-four of 112 recommended treatments were accessed using approved drugs, clinical trials, and single-patient investigational new drugs. After excluding the three subjects with nonbreast cancers and the two subjects who withdrew, 22 of 26 subjects (84.6%) received at least one ITOMIC Tumor Board–recommended treatment. CONCLUSION Further exploration of this approach in patients with mTNBC is merited.
Quantum Hall effect and magnetothermoelectric properties in a periodically modulated three-dimensional electron gas
Authors: Qi G. Y. , Ge Y. F. , Deng M. X. , Ma R. , Geng H. , Sheng L. , Chen W. , Xing D. Y. 
Published: March 2022

Abstract
In a periodically modulated three-dimensional (3D) electron gas subject to a magnetic field, the Hall conductivity exhibits quantized plateaus, which well correspond to the zero values of the transverse conductivity, a clear signature of the emergence of 3D quantum Hall effect (QHE). We develop a semiclassical theory for the 3D QHE system, taking into account the effect of the Landau level broadening and finite temperatures, to calculate the conductivities and thermoelectric transport coefficients. Our theory provides a concise unified theoretical description for the complex oscillation behavior of the conductivities and thermoelectric transport coefficients in a 3D QHE system. It may serve as a valuable assistance for understanding the simultaneously measured electrical and thermoelectric data in experiments.
SHBG, Bone Mineral Density, and Physical Function Among Injection Drug Users With and Without HIV and HCV
Authors: Dias Jenny Pena , Piggott Damani A , Sun Jing , Wehbeh Leen , Garza Joshua , Abraham Alison , Astemborski Jacquie , Moseley Kendall F , Basaria Shehzad , Varadhan Ravi , Brown Todd T 
Published: March 2022

Abstract

Context
Sex hormone–binding globulin (SHBG) is a glycoprotein that regulates the bioavailability of sex hormones and is higher in people with HIV (PWH) and hepatitis C virus (HCV). SHBG is associated with aging-related diseases, including osteoporosis and frailty in the general population. However, the relationship between SHBG concentration and bone mineral density (BMD) and physical function among PWH and HCV is unclear.

Objective
This study aimed to evaluate the association between chronic infection with HIV and HCV and SHBG, and to assess the relationship of circulating SHBG concentrations with low BMD, physical function impairment, and frailty.

Methods
A cross-sectional study was conducted of 278 HCV-exposed (HCV antibody positive) adults enrolled with and without HIV and HCV from the AIDS Linked to the IntraVenous Experience cohort study into 4 groups: HCV–/HIV–, HCV–/HIV+, HCV+/HIV–, and HCV+/HIV+. We evaluated the association between SHBG concentrations and grip strength, gait speed, Short Physical Performance Battery score, frailty (Fried Frailty Phenotype), and BMD (lumbar spine, total hip, and femoral neck T-score) by using adjusted multivariable regression stratified by sex.

Results
SHBG concentrations were higher in women, in those with HIV RNA greater than 400 copies/mL (P = .02) and HCV RNA greater than 15 IU/mL (P &lt; .001). In adjusted models, higher SHBG concentrations among women were statistically significantly associated with lower grip strength (–0.43 [95% CI, –0.77 to –0.081] kg/10 nmol/L, P &lt; .05), higher odds of frailty (odds ratio, 1.49 [95% CI, 1.07 to 2.08], P &lt; .05), and lower T-scores at the lumbar spine (–0.070 [95% CI, –0.15 to –0.001] SD/10 nmol/L T-score BMD, P &lt; .05). Similar associations were not observed among men.

Conclusion
Higher SHBG concentrations are associated with the presence of HIV and HCV viremia. Among women, but not men, higher SHBG concentrations were associated with lower grip strength, higher odds of frailty, and lower lumbar spine BMD. The underlying mechanisms of these associations require further investigation.
BMI and Contraceptives Affect New Age-, Sex-, and Puberty-adjusted IGF-I and IGFBP-3 Reference Ranges Across Life Span
Authors: Hörenz Charlott , Vogel Mandy , Wirkner Kerstin , Ceglarek Uta , Thiery Joachim , Pfäffle Roland , Kiess Wieland , Kratzsch Jürgen 
Published: March 2022

Abstract

Context
Various clinical factors influencing serum levels of insulin-like growth factor I (IGF-I) and its binding protein 3 (IGFBP-3) are not entirely consistently described.

Objective
We asked whether body mass index (BMI), contraceptive drugs (CDs), and hormone replacement therapy (HRT) have potential effects on data for interpreting new age-, sex-, and puberty-adjusted reference ranges for IGF-I and IGFBP-3 serum levels.

Design and Setting
Subjects were mainly participants from 2 population-based cohort studies: the LIFE Child study of children and adolescents and the LIFE Adult study.

Participants
We investigated 9400 serum samples from more than 7000 healthy and 1278 obese subjects between 3 months and 81 years old.

Main Outcome Measures
Associations between IGF-I or IGFBP-3, measured with a new electrochemiluminescence immunoassay, and the predictors BMI and CDs were estimated using hierarchical linear modeling.

Results
During infancy, obese children had up to 1 SD score (SDS) higher mean predicted IGF-I values, converging with levels of normal-weight subjects up to 13 years old. Between 20 and 40 years of age, obesity was related to up to −0.5 lower IGF-I SDS values than the predicted values. Obesity had less impact on IGFBP-3. Estrogen- and progestin-based CDs, but not HRT, decreased IGF-I and increased IGFBP-3 (P &lt; 0.01) in adolescents (β IGF-I = −0.45, β IGFBP-3  = 0.94) and adults (β IGF-I = –0.43, β IGFBP-3  = 1.12). Conversely, progestin-based CDs were significantly positive associated with IGF-I (β IGF-I  =0.82).

Conclusions
BMI and CDs must be considered when assessing and interpreting the clinical relevance of IGF-I and IGFBP-3 measurements.