bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of sample handling on the stability of interleukin-6 in patients with breast neoplasms
Authors: Wang Yunxiu , Wang Baiye , She Lanhui , Wang Jijuan , Chen Yingting , Huang Di , Han Guang , Lu Miaolian , Wu Xiaobin , Wan Zemin , He Min , Ke Peifeng , Huang Xianzhang , Liu Hongcan 
Published: March 2022

Abstract

Objectives
To investigate the influence of preservation methods and processes on the plasma interleukin-6 (IL-6) stability.

Methods
Lithium-heparin plasma was collected from female patients: 32 female patients with invasive breast neoplasms and 20 healthy females. Each sample was divided into three tubes. Samples were stored at different temperatures or at different times. The concentration of IL-6 was detected.

Results
IL-6 levels in patients were not altered significantly compared to the control group after storage at 4 °C or 25 °C for 12 h. However, IL-6 levels were significantly higher compared to controls (p<0.05) after storage at 25 °C for 48 h. IL-6 levels in patients with breast neoplasms were significantly higher compared to the control group (p<0.05) when stored at 4 °C after 12 h. IL-6 levels in patients with breast neoplasm increased more than 10-folds compared to the control group after only 2 h storage at 25 °C.

Conclusions
Concentrations of IL-6 in breast neoplasms samples significantly change under different storage conditions. Pretreatment needs to be standardized for blood sample handling procedure. Comparison of different storage conditions of IL-6 levels may not be reliable.
Exact path integral solutions of Dirac wave equation for an exponentially decaying magnetic field
Authors: Boudiaf Nadira , Merdaci Abdeldjalil , Chetouani Lyazid 
Published: March 2022

Abstract
The Green’s functions related to a Dirac electron and its corresponding antiparticle, i.e., the positron submitted to an exponentially decaying magnetic field in (2 + 1) coordinate space are analytically calculated via path integral formalism. The energy spectra for both discrete and continuous phenomena, as well as the corresponding normalized eigenspinors are extracted following this approach from the known Morse potential propagator. The interesting properties of the spinors are thus deduced after symmetrization of the Green’s functions. Special cases are also considered.
El origen del humanismo de la Bauhaus (1919-1933) en la cultura clásica griega: una mirada a través del alumnado femenino
Authors: Vadillo Rodríguez Marisa 
Published: March 2022

El objetivo de esta investigación plantea una reflexión inédita que enlaza la pedagogía de la célebre Bauhaus (1919-1933) con ideales clásicos humanistas, cuyo origen esencial lo situamos en la Grecia clásica: physis, paideia, el templo, la armonía y la geometría. La investigación se ha basado en una metodología de estudio histórico y hermenéutico de carácter cualitativo, cuyas fuentes primarias son documentos originales conservados en el Bauhaus-Archiv de Berlín junto a bibliografía internacional consultada en The Warburg Institute de la Universidad de Londres, ya que gracias a esta se contextualizaron los datos previos del archivo alemán sobre la cultura griega clásica. Con el fin de visibilizar esta vinculación en su realidad más inexplorada, los referentes y figuras que se han usado en la investigación han sido acotados al alumnado femenino como sujetos menos conocidos en la producción artística general de la escuela. El artículo confirma y demuestra la tesis inicial sostenida: que la Bauhaus –posiblemente la última escuela humanista clásica en Europa– estaría más cercana a la cultura griega de lo que se ha considerado hasta ahora, este fenómeno, que permitió el salto a las vanguardias, estuvo presente en la producción de sus alumnas.
Development of the STEM-Pedagogical Content Knowledge Scale for Pre-service Teachers: Validity and Reliability Study
Authors: Akçay Behiye , Avcı Filiz 
Published: March 2022

This study aims to develop a valid and reliable scale to determine the STEM-Pedagogical Content Knowledge (STEM-PCK) levels of pre-service teachers. This study was conducted in the 2018-2019 academic year with 322 pre-service teachers in Turkey. In the study, one of the mixed method typologies, Exploratory Sequential Design was applied. The scale was submitted for evaluation by four experts to determine the content and face validity. Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) was performed to determine the construct validity of the scale. As a result of EFA, the scale had five factors including STEM Pedagogical Knowledge, Pedagogical Knowledge, Engineering Pedagogical Knowledge, Mathematics Pedagogical Knowledge and Science Pedagogical Knowledge.As a result of CFAχ ² / df = 2.7085, RMSEA = .073, RMR = 0.0420, SRMR = .0667, NFI = .940, NNFI = .960, CFI = .961, IFI = .962, RFI = .938 values were reached and the factor structure determined to be suitable.To determine the reliability of the scale, internal consistency and test-retest reliability analyzes were made. Internal consistency reliability value of the scale was found as .977. The final form of the STEM-PCK scale is a 5-point Likert type that includes 57 items and 5 factors.
Experience of intracavernous silicone prosthesis implantation for erectile impotence
Authors: Lobkarev O. A. 
Published: March 2022

At present time surgical treatment of erectile impotence is gaining more and more supporters.
40 surgical aids for persistent erectile dysfunction were performed at the urological department of the Republican Clinical Hospital of the TASSR Ministry of Health Care in 1985-1987. Prostheses were implanted in both cavernous bodies in 30 patients and in one body in 10 patients. The indications for surgical treatment were complete absence of adequate and spontaneous erections during three years of unsuccessful treatment by a sexopathologist, absence of auditory and visual stimulation, partial regression of libido.
Features of diagnostics and treatment of thyrotoxicosis in patients with severe comorbid pathology: clinical case
Authors: Styazhkina S. N. , Chernyadeva E. V. , Karmanova V. V. , Sazhina K. I. , Korobeinikov V. I. 
Published: March 2022

Objective. To demonstrate the stages of diagnostics and successful treatment of thyrotoxicosis in a patient with severe comorbid pathology.
Materials and methods. A clinical case report of a patient with toxic goiter is presented.
Results. To specify the state of the thyroid gland, diagnostic and laboratory methods were applied: ultrasound examination (thyroid volume increased up to 182 cm2, isoechogenic nodule in the left lobe up to 1 cm, thyroid vascularization increased), spiral computed tomography (picture of diffuse nodular goiter with partial retrosternal location of the left thyroid lobe), hormone studies, the results of which revealed thyrotoxicosis. Thyroidectomy was subsequently carried out. Both thyroid lobes with isthmus were removed step-by-step with technical difficulties and high bleeding of tissues. The patient was discharged in 10 days in a satisfactory state.
Conclusions. Thyrotoxicosis is certainly a complex surgical pathology, in which correct assessment of the diagnosis by instrumental, clinical and laboratory methods is required, as well as successful surgical intervention. Not only normalization of hormonal status of a patient has to be taken into account, but also the possibility of disease relapse, contraindications due to age, physiological status, and comorbid abnormalities.
Modification of liver reparative regeneration in laboratory animals after partial hepatectomy
Authors: Maksimova A. Yu. , Valamina I. E. , Polushina L. G. , Tsvirenko S. V. , Bazarnyi V. V. 
Published: March 2022

Objective. To investigate the effect of cytoflavin on the adaptive liver growth after partial hepatectomy (PH).
Materials and methods. An experimental study was conducted on 60 male white mice aged 78 months, weighing 2431 g. All animals were divided into three groups: group 1 intact mice; group 2 operated control mice, who received saline NaCl instead of the drug; group 3 the main group of animals, who underwent partial hepatectomy, after which they received сytoflavin. Partial hepatectomy was performed by Claudia Mitchell and Holger Willenbring technique (2008). The preparation cytoflavin (Russia) was injected intraperitoneally at a dose of 0.014 ml /10 g of body weight for 7 days once daily. Morphological and morphometric studies of hepatobiopsy specimens were conducted. Statistical analysis was carried out using the methods of nonparametric statistics.
Results. It was found that 3 days after PH, in the liver of animals of the main group, the number of dystrophically altered hepatocytes decreased by 25 times, the mitotic index increased against the background of the preserved radial-beam structure. There was an increase in the size of the cytoplasm and nucleus by 1.5 times relative to the intact group (p 0.05), that is associated with adaptive hypertrophy. At the same time, on the 3rd day, in the control group the number of dystrophically altered cells was several times higher than in the intact animals and was accompanied by an increase in the cytoplasm of hepatocytes as a result of vacuolar degeneration after PH.
Conclusions: The use of cytoflavin leads to an increase in the mitotic activity of the partially resected liver, while the level of binuclear cells decreases. The manifestations of hepatocyte dystrophy also decrease. Comparison of the dynamics of the morphometric parameters of hepatocytes in animals of the control group and those who received cytoflavin after PH suggests that the studied drug stimulates the recovery processes in the liver during induced regeneration.
Efektivitas Karbon Aktif dalam Pembuatan Garam Rumput Laut Cokelat (Sargassum polycystum dan Padina minor)
Authors: Manteu Shindy Hamidah , Nurjanah Nurjanah , Abdullah Asadatun , Nurhayati Tati , Seulalae Anggrei Viona 
Published: March 2022

Rumput laut cokelat memiliki potensi menjadi bahan baku garam diet untuk hipertensi, namun terdapat permasalahan dari produk akhir garam rumput laut yaitu aroma khas rumput laut (amis) yang masih kuat. namun Bahan alami yang dapat mencegah aroma ini salah satunya adalah karbon aktif. Tujuan penelitian adalah menentukan konsentrasi karbon aktif dalam proses pembuatan garam S. polycystum dan P. minor untuk menghasilkan garam yang bisa diterima oleh masyarakat. Metode yang digunakan dengan perlakuan konsentrasi karbon aktif berbeda (0%, 0,50%, 0,75%, 1%, 1,25%, 1,50% (b/v)) pada proses pembuatan garam, uji sensori aroma dan karakterisasi garam rumput laut. Karakteristik garam meliputi kadar mineral (Mg, Fe, Ca, Na, K), rasio Na:K, kadar NaCl dan aktivitas antioksidan. Konsentrasi karbon aktif optimum garam S. polycystum 1,50% dengan karakteristik Mg 29,24 mg/g; Fe 0,15 mg/g; Ca 27,66 mg/g; rasio Na:K 0.87 mg/g; NaCl 33.87%; aktivitas antioksidan 201,0 mg/L. Konsentrasi karbon aktif optimum garam P. minor yaitu 1% dengan karakteristik Mg 39,05 mg/g; Fe 0,03 mg/g; Ca 32,28 mg/g; rasio Na:K 1,97 mg/g; NaCl 28.34% dan aktivitas antioksidan111,39 mg/L.
Source Process Featuring Asymmetric Rupture Velocities of the 2021 Mw 7.4 Maduo, China, Earthquake from Teleseismic and Geodetic Data
Authors: Li Qi , Wan Yongge , Li Chengtao , Tang He , Tan Kai , Wang Dongzhen 
Published: March 2022

AbstractOn 21 May 2021, an Mw 7.4 left-lateral strike-slip earthquake occurred within the Bayan Har block in the Tibetan plateau. To learn about the source rupture process, we collected the teleseismic waveforms and utilized the backprojection method to investigate the rupture kinematics of the earthquake. The results indicate that the earthquake was a bilateral rupture event with asymmetric rupture velocities. The rupture velocity in the east of the epicenter was uniform and in the range of 2.72–3.67 km/s, whereas, in the west, it was in the range of 1.39–1.78 km/s in the first 20 km and then increased to 2.82–3.17 km/s. The slip distribution constrained by the Interferometric Synthetic Aperture Radar and Global Positioning System displacements clearly reveals kinematic coseismic slip in greater detail, which makes up for the limitations of the backprojection method. Two main asperities in the east verify the results of the backprojection method. The rupture depth in the west was slightly shallower than that in the east, which may be the reason for the asymmetry of rupture velocities. The initial rupture point was updated based on the asymmetric velocities and geodetic slip distribution. The multiple-point-source moment tensors based on the rupture velocities and new initial rupture point not only match the fault geometries determined by relocated aftershocks but also fit well with the released energy distribution, which proves the asymmetry of rupture velocities.
Effects of Probiotics, Prebiotics and Synbiotic Supplementation on Cognitive Impairment: A Review
Authors: Mukilan Murugan 
Published: March 2022

Learning and memory formation are the two essential terms widely used in the field of cognition. Learning can be defined as acquiring new information or skills. Memory is formed due to changes in the neuronal system as a result of continuous stimulus exposure. Both learning and memory are fundamental processes that occur in all living organisms. Memory is broadly categorized into two different categories such as short-term memory (STM) and long-term memory (LTM). Compared to STM, LTM plays an essential role in the day-to-day activities of different living organisms. LTM requires RNA and protein synthesis-dependent mechanisms for memory storage, which lasts up to their lifetime. LTM formation is initiated when the neurotransmitters are released from the presynaptic neuron; further released neurotransmitters bind with their respective receptors present in the postsynaptic neuron and initiate the calcium influx. Calcium influx results in the further activation of molecules involved in the neuronal signaling pathway and results in memory formation. Present review reports the outcome of recent studies which showed that probiotic supplement is responsible for the retrieval of memory in case of memory impairment and its uses in the treatment of neurodegenerative disorders like mild cognitive impairment (MCI), Alzheimer's disease (AD). Recent research studies were shown that probiotic microorganisms may positively regulate neurotransmitter release and increase the calcium influx, brain derived neurotrophic factor (BDNF), and N-methyl-D-aspartate receptor (NMDAR) and plays a pivotal role in the LTM formation in gut-dysbiosed & memory-impaired animal models.
Determination of Trace Elements in Sediments Samples by Using Neutron Activation Analysis
Authors: Krishnan Kumar , Saion Elias B. , CK Yap , Chong Mee Yoke , Nadia A. S. 
Published: March 2022

The Juru River is a highly industrialized, urbanized, and agricultural catchment. This study aimed to investigate trace elements in Juru mangrove sediments, including geochemical baselines and enrichment. Sediment was collected from the mangrove in Juru, Penang, Malaysia. A total of eight target elements was examined. Instrumentation activation analysis (INAA) was used to determine the concentration of Fe, V, Cr, Zn and Co. Atomic absorption spectrometry (AAS) was used to determine the concentration of elements that not detectable by INAA (Cd, Pb, and As). In both methods, validated reference material studies were used for validation of the methodology. Metal pollution was estimated using the Enrichment Factor (EF), Geoaccumulation Index (Igeo), Contamination Factor (CF), and Pollutant Load Index (PLI). The EF, Igeo, and CF ranges from 0.45–7.96, -2.18 – 1.95, and 0.33–5.83 respectively. The order of accumulation of the elemental concentration found was Fe > Zn> Cr > V > Pb > As > Co >Cd. The computed mean value of PLI exceeds the unit (PLI > 1).
Projeto de Extensão Reconstruindo a Cidadania
Authors: Dare Mônica Elizabeth , Pirolla Douglas Leffa , Prado Rafael José , Zancan Evelise Chemalle 
Published: March 2022

Projeto de Extensão Reconstruindo a Cidadania Daré, Mônica Elizabeth[1]Pirolla, Douglas Leffa[2]Prado, Rafael José[3]Zancan, Evelise Chemalle[4]1- IntroduçãoSegundo Paiva e Salgado (2003) a educação dos operários, sem dúvida alguma, contribui para que eles tenham condições de assimilar novas técnicas, aceitando avanços nas existentes, diminuindo os erros de execução, que geram não conformidades, e, portanto, o retrabalho, os acidentes de trabalho e o desperdício. Diante destas questões o objetivo deste projeto é promover a preparação e a capacitação para as pessoas em vulnerabilidade social e/ou trabalhadores na construção civil, nas categorias profissionais pertinentes às equipes de obras, proporcionando oportunidades de integração e compreensão do ambiente de trabalho, para melhor inserção no meio social e do trabalho. O projeto de extensão Reconstruindo a Cidadania desenvolve suas atividades desde 2010 em parcerias com várias entidades, instituições e empresas. A empresa Farben Tintas S.A. constitui-se parceira permanente do projeto, e como outras parcerias, em várias edições anteriores, têm-se a Prefeitura Municipal de Criciúma, a Prefeitura Municipal de Jacinto Machado, a Acijam (Associação Comercial de Jacinto Machado), a Associação Beneficente ABADEUS, e a Prefeitura Municipal de Cocal do Sul. A partir do ano de 2017 a entidade Bairro da Juventude tornou-se parceira do projeto. Destaca-se dentro do projeto o módulo de pintura imobiliária e moveleira que promove aos participantes a preparação e a capacitação para atividades de pintura na construção civil e na indústria de móveis.[1]Especialista, Unesc, dare@terra.com.br[2]Acadêmico, Unesc, dpirolla@unesc.net[3]Acadêmico, Unesc, rafael-do-p@hotmail.com[4]Mestre, Unesc, ecz@unesc.net
Análise do concreto de pós reativos sustentável com dois diferentes tipos de areia
Authors: Piccinini Ângela Costa , José Jonas Carvalho 
Published: March 2022

1. IntroduçãoDevido às demandas do mercado da construção civil, novos materiais precisam ser desenvolvidos, seja em função da necessidade de maior capacidade de carga, de menor permeabilidade, de maior durabilidade, ou de quaisquer características necessárias para sua aplicação.[1] Segundo Soto [2], após o concreto convencional, já houve o desenvolvimento do concreto de alta resistência, o concreto de alto desempenho e, mais recentemente, o concreto de ultra alto desempenho. O concreto de pós reativos ou somente CPR pode atingir resistências de um concreto de ultra alto desempenho. São concretos formados de partículas com diâmetro máximo menor que 2mm, que estão aplicados em elementos estruturais. O material oferece grandes resistências à compressão e, também, à tração e à flexão, quando utilizada cura térmica. [3]. No CPR, por ser uma mistura composta por materiais de baixa granulometria, são eliminados os vazios da estrutura internamente, ganhando uma maior resistência e homogeneidade. A utilização do CPR em outros países já possibilitou construções mais leves, esbeltas, de baixo custo de manutenção e com maior vida útil. O custo e a metodologia de produção são as desvantagens. Com isso, este trabalho visa diminuir o custo da mistura de um CPR, além de presar pela parte ambiental, com a substituição em, aproximadamente, 35% de cimento pela escória de alto forno e com dois tipos diferentes de areia. Não será utilizada cura térmica na produção.2. MetodologiaO traço foi baseado na pesquisa de Yang et al [4]. Os materiais constituintes do CPR foram cimento CP-V ARI, escória de alto forno, sílica, areia, superplastificante e relação água/cimento de 0,16. Foram analisados 12 corpos de prova, sendo 6 com areia n. 50 (retida na peneira 0,3mm) padronizada, fornecida pelo Instituto de Pesquisa e Tecnologia, e 6 com areia de praia da região de Osório, RS, com diâmetro médio de 0,15 mm. Os corpos de provas (CP) foram submetidos a ensaios de compressão axial aos 7 e aos 28 dias.3. ResultadosA resistência à compressão com areia do IPT, aos 7 dias foi de 73,49 MPa, sendo 63,64% acima da resistência com a areia de praia. E aos 28 dias, com areia de praia, a resistência foi de 62,22 MPa e com areia do IPT de 84,7 MPa. Com relação à idade, o aumento foi maior, 38,54%, com a areia de praia, dos 7 aos 28 dias.4. ConclusõesPor ser um concreto ecoeficiente, com menor consumo de cimento, reduzindo custo e impacto ambiental, os resultados encontrados foram satisfatórios, ficando acima da média para um concreto comum, e com maior durabilidade por possuir menos vazios. Pode-se perceber que com a utilização de uma areia padronizada os resultados da resistência à compressão foram mais satisfatórios.
DNA metabarcoding of benthic algae and associated eukaryotes from Lake Baikal in the face of rapid environmental changes
Authors: Bukin Yu. S. , Kravtsova L. S. , Peretolchina T. E. , Fedotov A. P. , Tupikin A. E. , Kabilov M. R. , Sherbakov D. Yu. , Mincheva E. V. 
Published: March 2022

Here we report new data describing the biodiversity of phytobenthic communities based on DNA-metabarcoding using the 18S rDNA marker and the Illumina MiSeq system. The study was initiated due to the blooming of filamentous algae (mainly of the genus Spirogyra) and cyanobacteria in the coastal zone of Lake Baikal under climate change and anthropogenic impact. The composition and taxonomic diversity of algae and other organisms associated with them on different sites of Lake Baikal (near Bolshoi Ushkaniy Island, in Listvennichny Bay) and in the Kaya (within the city of Irkutsk, located in the same drainage basin as Lake Baikal) were determined using DNAmetabarcoding. About 15 thousand reads of the 18S rRNA marker were obtained by applying NGS (next-generation sequencing). The species of algae dominating in the number of reads, as well as the difficult-to-identify taxa (Stramenopiles, Alveolata, Euglenozoa, Chromista, Rhizaria, Amoebozoa, etc.), which play an important role in the functioning and formation of the structure of algal communities, were revealed. The Shannon index of the communities studied ranges from 1.56 to 2.72. The advantages and weaknesses of using DNA-metabarcoding based on the 18S rRNA gene fragment for studying the structure of algal communities are shown. The advantage of this method is the possibility to more fully determine the diversity of eukaryotes taxa, which are difficult to identify by morphology, without involving a large number of specialists, while the disadvantage of the method is the distortion that may occur during the PCR. Here, ways of solving this problem are proposed. The results of the study show that the analysis of the minor component of the eukaryotic community in samples (organisms with low biomass) consisting of a mixture of multicellular and unicellular organisms requires a read-depths of at least 100,000 sequences per sample. In general, the DNA-metabarcoding method is recommended for studying the structure of algal communities and eukaryotes associated with them.