bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel high-efficiency Poly(butyl acrylate-co-2-ethylhexyl acrylate) grafting of Poly(methyl methacrylate) impact modifier: Synthesis and application
Authors: Sun Yinan , Liu Xiangchi , Liu Tingting , Liu Baijun , Zhang Mingyao 
Published: July 2022

Polyacrylate latexes with uniform particle size and excellent dispersion were successfully synthesized via emulsion copolymerization of butyl acrylate and 2-ethylhexyl acrylate with different types of grafting agents. The effect of grafting agent type for residual double bonds of seed latex was discussed. The results indicated that the residue double bonds of acrylic seed latex of graft agents with non-equally active double bonds were higher than acrylic seed latex of graft agents with equally active double bonds. Acrylic impact modifiers (ACR) were generated by using an emulsion grafting polymerization of polyacrylate latex as the core and poly (methyl methacrylate) (PMMA) as the shell for preparing poly(vinyl chlorid) (PVC)/ACR blends. Mechanical properties test analysis shows that the PVC/ACR blend reached a brittle-toughness transition when the ACR content was 8 phr, indicating that modifiers play a good toughening role in the matrix. The highest impact strength of PVC toughened through ACR (dicyclopentenyl acrylate as grafting agent) was 1682 J/m, almost 62 times than the pure PVC, whereas only 45 times than the pure PVC that of traditional ACR prepared PVC/ACR blend. Scanning electron microscope graphs showed that the shear yielding of the matrix was the major toughening mechanisms.
Fear of Covid-19 and Hotel Frontline Employees’ Sense of Work Alienation: Intervening and Interactional Analysis
Authors: Peng Michael Yao-Ping , Khalid Adeel , Usman Muhammad , Khan Muhammad Aamir Shafique , Ali Moazzam 
Published: July 2022

The present study examines the role of death anxiety as an important mechanism underlying the relationship between fear of Covid-19 and hotel frontline employees’ (FLEs) sense of work alienation. Importantly, the study proposes FLEs’ intrinsic spirituality as being a relevant boundary condition. Results, based on time-lagged survey data (three rounds, 2 weeks apart) from 203 FLEs in 91 hotels and analyzed using structural equation modeling, reveal that death anxiety mediates the association between fear of Covid-19 and work alienation. In addition, FLEs’ intrinsic spirituality moderates the direct relationship between fear of Covid-19 and death anxiety and the indirect relationship between fear of Covid-19 and work alienation, such that the relationships are weak when intrinsic spirituality is high (vs. low). The study offers several important suggestions that can help hospitality managers address FLEs’ sense of work alienation during traumatic conditions. Highlights Death anxiety mediates the relationship between fear of Covid-19 and work alienation. Intrinsic spirituality moderates the link between fear of Covid-19 and death anxiety. Intrinsic spirituality moderates the indirect fear of Covid-19-work alienation link. The findings can help hotel managers address FLEs’ sense of work alienation.
Migrating to Long-Read Sequencing for Clinical Routine BCR-ABL1 TKI Resistance Mutation Screening
Authors: Schaal Wesley , Ameur Adam , Olsson-Strömberg Ulla , Hermanson Monica , Cavelier Lucia , Spjuth Ola 
Published: July 2022

Objective: The aim of this project was to implement long-read sequencing for BCR-ABL1 TKI resistance mutation screening in a clinical setting for patients undergoing treatment for chronic myeloid leukemia. Materials and Methods: Processes were established for registering and transferring samples from the clinic to an academic sequencing facility for long-read sequencing. An automated analysis pipeline for detecting mutations was established, and an information system was implemented comprising features for data management, analysis and visualization. Clinical validation was performed by identifying BCR-ABL1 TKI resistance mutations by Sanger and long-read sequencing in parallel. The developed software is available as open source via GitHub at https://github.com/pharmbio/clamp Results: The information system enabled traceable transfer of samples from the clinic to the sequencing facility, robust and automated analysis of the long-read sequence data, and communication of results from sequence analysis in a reporting format that could be easily interpreted and acted upon by clinical experts. In a validation study, all 17 resistance mutations found by Sanger sequencing were also detected by long-read sequencing. An additional 16 mutations were found only by long-read sequencing, all of them with frequencies below the limit of detection for Sanger sequencing. The clonal distributions of co-existing mutations were automatically resolved through the long-read data analysis. After the implementation and validation, the clinical laboratory switched their routine protocol from using Sanger to long-read sequencing for this application. Conclusions: Long-read sequencing delivers results with higher sensitivity compared to Sanger sequencing and enables earlier detection of emerging TKI resistance mutations. The developed processes, analysis workflow, and software components lower barriers for adoption and could be extended to other applications.
Internet addiction in adolescent psychiatric patient population: A hospital-based Study from China
Authors: Zhou Rui , Zhang Ji-Jie , Liu Yin-Du , Chen Hong-Bei , Wang Shi-Bin , Jia Fu-Jun , Hou Cai-Lan 
Published: July 2022

Background Internet is gradually reshaping adolescents’ behaviors in China. It is important to identify the prevalence and risk factors to predict Internet addiction among adolescent psychiatric patients. Methods The survey was conducted among inpatient or outpatient adolescent patients with mental disorders. All participants were interviewed face-to-face and completed Young Internet Addiction Test and other relevant assessments. Binary logistic regression analysis was used to exam between-group differences of internet addiction. Result The prevalence for internet addiction (mild to severe) in adolescent psychiatric patients was 80.2%, where the prevalence for “medium and severe internet addiction was 25.5%. Logistic regression analysis identified two independent predictors for “medium and severe internet addiction” including the total score of Adolescent Non-suicidal-self-injury (NSSI) Behavior Function Assessment Scale (ANBFAS) and the diagnosis of generalized anxiety disorder (GAD) (R2 =0.27, p = .02 for total ANBFAS score, p = .01 for GAD) in psychiatric adolescent patients. Conclusion The prevalence of internet addiction is notably high among adolescent psychiatric patients in China. Coping for Internet addiction in adolescent psychiatric patients should conclude the coping of NSSI and GAD.
Risk factors for the development of new-onset and persistent postpartum preeclampsia: A case–control study in Ghana
Authors: Fondjo Linda Ahenkorah , Amoah Beatrice , Tashie Worlanyo , Annan John Jude 
Published: July 2022

Background: Postpartum preeclampsia has been implicated in increasing hospital re-admissions, maternal morbidity, and mortality worldwide. The knowledge of the risk factors of postpartum preeclampsia would be helpful in formulating strategies to aid in the prevention, early diagnosis, and timely treatment of this disorder. Thus, this study aimed to identify the risk factors associated with the development of new-onset postpartum preeclampsia and persistent postpartum preeclampsia in the Ghanaian setting. Methods: This case–control study was conducted at the Obstetrics and Gynecology units of Komfo Anokye Teaching Hospital and the Kumasi Regional Hospital, both located in the Ashanti Region of Ghana. A total of 65 postpartum preeclamptic women (33 new-onset postpartum preeclampsia and 32 persistent postpartum preeclampsia) and 65 normotensive postpartum mothers were recruited from 48 h to 6 weeks post-delivery. Questionnaires were administered to assess the socio-demographic, lifestyle, obstetric characteristics, and past medical history of the study participants. Results: Physical inactivity ( p < 0.0001), infrequent antenatal visits ( p < 0.0001), analgesic use ( p < 0.0001), and cesarean delivery ( p = 0.021) were significantly associated with both the new-onset postpartum preeclampsia and persistent postpartum preeclampsia. Contraceptive use was significantly associated with the development of new-onset postpartum preeclampsia ( p < 0.0001) while women with low-birthweight babies are also at high risk of developing persistent postpartum preeclampsia ( p  < 0.0001). Conclusion: Physical inactivity, infrequent antenatal visits, analgesic use, contraceptive use, and cesarean delivery are major predisposing risk factors for the development of postpartum preeclampsia. Screening using these risk factors, close monitoring and follow-up observation of women after delivery would be beneficial in identifying and managing postpartum preeclampsia.
Impact of coronavirus 2019 pandemic on post-traumatic stress disorder symptoms among pregnant women in Jordan
Authors: Bataineh Mo’ath F , Mohamad Maysm N , Al Dhaheri Ayesha S , Rawashdeh Monketh , Al-Nawaiseh Ali M , Asali Fida F , Hashim Mona , Jarrar Amjad , Abu Jamous Dima O , Stojanovska Lily , Daour Rameez Al , Saleh Sheima T , Osaili Tareq M , Cheikh Ismail Leila 
Published: July 2022

Objective: To examine the prevalence of psychological symptoms of the coronavirus disease 2019 outbreak among pregnant women and its association with gestational age and post-traumatic stress disorder symptoms. Methods: A cross-sectional study was conducted between June and November 2020 to assess the impact of the COVID-19 pandemic on mental health in pregnancy using the Impact of Event Scale-Revised. Pregnant women 18 years and older were recruited from antenatal and obstetrics clinics in Jordan. A total of 481 pregnant women participated in an online survey developed on Google Forms. A self-administered structured questionnaire was used to collect sociodemographic data, mental health information, and lifestyle changes. The Impact of Event Scale-Revised, the Perceived Support Scale, and the Mental Health Lifestyle Scale were administered. Variables related to sociodemographic information and dietary behavior and perception during the COVID-19 pandemic were also assessed. Results: The results showed that 58.6% of pregnant women reported the presence of post-traumatic stress disorder symptoms and women in the second trimester were more likely to show post-traumatic stress disorder symptoms compared with the first and third trimesters ( p = 0.001). Moreover, a higher level of education, employment, poor dietary habits, and changes due to the pandemic were significantly associated with the Impact of Event Scale-Revised score and the presence of post-traumatic stress disorder symptoms. Conclusion: The COVID-19 pandemic was associated with high rates of psychological distress among pregnant women. Identifying mothers at risk of post-traumatic stress disorder symptoms may help improve maternity services and prevent adverse child outcomes.
Association of early changes of circulating cancer stem-like cells with survival among patients with metastatic breast cancer
Authors: Chang Pei-Hung , Lee Chun-Hui , Wu Tyler Min-Hsien , Yeh Kun-Yun , Wang Hung-Ming , Huang Wen-Kuan , Chan Sheng-Chieh , Chou Wen-Chi , Kuan Feng-Che , Kuo Hsuan-Chih , Kuo Yung-Chia , Hu Ching-Chih , Hsieh Jason Chia-Hsun 
Published: July 2022

Background: This study aimed to investigate the role of circulating tumor cells (CTCs) and circulating cancer stem-like cells (cCSCs) before and after one cycle of chemotherapy and assessed the effects of early changes in CTCs and cCSCs on the outcomes of patients with metastatic breast cancer. Methods: Patients with stage IV invasive ductal carcinoma of the breast who received first-line chemotherapy between April 2014 and January 2016 were enrolled. CTCs and cCSCs were measured before the first cycle of chemotherapy (baseline) and on day 21, before the second cycle of chemotherapy commenced; a negative selection strategy and flow cytometry protocol were employed. Results: CTC and cCSC counts declined in 68.8 and 45.5% of patients, respectively. Declines in CTCs and cCSCs following the first chemotherapy cycle were associated with superior chemotherapy responses, longer progression-free survival (PFS), and longer overall survival (OS). An early decline in cCSCs remained an independent prognostic indicator for OS and PFS in multivariate analysis. Conclusions: A cCSC decline after one cycle of chemotherapy for metastatic breast cancer is predictive of a superior chemotherapy response and longer PFS and OS, implying that cCSC dynamic monitoring may be helpful in early prediction of treatment response and prognosis.
Association of proton pump inhibitor use with survival outcomes in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis
Authors: Chen Baoqing , Yang Chen , Dragomir Mihnea P. , Chi Dongmei , Chen Wenyan , Horst David , Calin George A. , Li Qiaoqiao 
Published: July 2022

Background: Proton pump inhibitors (PPIs) have been shown to regulate the gut microbiome and affect the response to immune checkpoint inhibitors (ICIs). Contradictory results on survival have been observed in patients concomitantly treated with ICIs and PPIs. We performed a systematic review and meta-analysis to determine the association between PPI use and survival outcomes in ICI-treated cancer patients. Methods: EMBASE, MEDLINE/PubMed, Cochrane Library databases, and major oncology conference proceedings were searched. Studies comparing overall survival (OS) and progression-free survival (PFS) between PPI-treated and PPI-free groups of ICI-treated cancer patients were included. Data regarding study and patient characteristics, ICI and PPI treatments, and survival outcomes were extracted. Hazard ratios (HRs) with 95% confidence interval (CI) were pooled using random effects models. Subgroup meta-analyses and meta-regressions were performed to explore possible factors of heterogeneity among the studies. Results: A total of 33 studies were included, comprising 7383 ICI- and PPI-treated patients and 8574 ICI-treated and PPI-free patients. The pooled HR was 1.31 (95% CI, 1.19–1.44; p < 0.001) for OS and 1.30 (95% CI, 1.17–1.46; p < 0.001) for PFS, indicating a significant negative association between PPI use and survival in ICI-treated patients. Subgroup meta-analyses by factors including cancer type, ICI type, and time window of PPI use revealed that ICI and PPI use impacted survival in patients with non-small cell lung or urothelial cancer, patients treated with anti-PD-1/PD-L1 antibodies, and patients receiving PPI as baseline treatment or 60 days before ICI treatment initiation. Conclusions: PPI use in patients treated with ICIs was associated with shorter OS and PFS, especially in several specific subgroups of cancer patients. PPIs should be strictly controlled and appear to not impact survival if given temporarily after ICI initiation. These observations could provide the basis for clinical guidelines for concomitant PPI and ICI use.
Efficacy of local therapy to metastatic foci in nasopharyngeal carcinoma: large-cohort strictly-matched retrospective study
Authors: Zhang Meng-Xia , Liu Ting , You Rui , Zou Xiong , Liu Yong-Long , Ding Xi , Duan Chong-Yang , Xu Han-Shi , Liu You-Ping , Jiang Rou , Wang Zhi-Qiang , Lin Chao , Xie Yu-Long , Chen Si-Yuan , Ouyang Yan-Feng , Xie Ruo-Qi , Hua Yi-Jun , Sun Rui , Huang Pei-Yu , Wang Shun-Lan , Chen Ming-Yuan 
Published: July 2022

Background: Studies of local therapy (LT) to metastatic foci from nasopharyngeal carcinoma (NPC) are inconsistent and controversial. Here, we aimed to explore the survival benefit of LT directed at metastatic foci from NPC. Methods: A retrospective analysis was conducted in NPC patients with liver, lung, and/or bone metastases. The postmetastatic overall survival (OS) rate was analyzed using the Kaplan–Meier method and compared by the log-rank test. Multivariate analysis was performed using the Cox hazard model. Subgroup analyses evaluating the effect of LT were performed for prespecified covariates. Propensity score matching was applied to homogenize the compared arms. Results: Overall, 2041 of 2962 patients were eligible for analysis. At a median follow-up of 43.4 months, the 5-year OS improved by an absolute difference of 14.6%, from 46.2% in the LT group versus 31.6% in the non-LT group, which led to a hazard ratio of 0.634 for death ( p < 0.001). Matched-pair analyses confirmed that LT was associated with improved OS ( p = 0.003), and the survival benefits of LT remained consistent in the subcohorts of liver and lung metastasis ( p = 0.009 and p = 0.007, respectively) but not of bone metastasis (BoM; p = 0.614). Radiotherapy was predominantly used for BoM and biological effective dose (BED) >60 Gy was found to yield more survival benefit than that of BED ⩽ 60 Gy. Conclusions: The addition of LT directed at metastasis has demonstrated an improvement to OS compared with non-LT group in the present matched-pair study, especially for patients with liver and/or lung metastases.
The presence and size of intrahepatic tumors determine the therapeutic efficacy of nivolumab in advanced hepatocellular carcinoma
Authors: Kim Han Sang , Kim Chang Gon , Hong Jung Yong , Kim Il-hwan , Kang Beodeul , Jung Sanghoon , Kim Chan , Shin Sang Joon , Choi Hye Jin , Cheon Jaekyung , Chon Hong Jae , Lim Ho Yeong 
Published: July 2022

Purpose: Inter-tumoral heterogeneity at the differential lesion level raises the possibility of distinct organ-specific responses to immune checkpoint inhibitors (ICIs). We aimed to comprehensively examine the clinicopathological factors to predict and assess the efficacy of nivolumab, programmed cell death protein 1 (PD-1) blockade at an individual tumor site-specific level in patients with advanced hepatocellular carcinoma (aHCC). Patients and Methods: We enrolled 261 aHCC patients treated with nivolumab between 2012 and 2018. Eighty-one clinicopathological factors were comprehensively collected and analyzed. The association between all variables and survival outcomes was evaluated. According to tumor site, the organ-specific responses were assessed based on the Response Evaluation Criteria in Solid Tumors, version 1.1. Results: The liver was the most commonly involved organ (75.1%), followed by the lungs (37.5%) and lymph nodes (LNs, 11.5%). The liver of nonresponders was more frequently the organ of progression, while the lungs of responders were more frequently the organs of response. Among the 455 individual lesions (liver, n = 248; lung, n = 124; LN, n = 35; others including bone or soft tissues, n = 48), intrahepatic tumors showed the least response (10.1%), followed by lung (24.2%) and LN tumors (37.1%), indicating the presence of distinct organ-specific responses to nivolumab. In intrahepatic tumors, the organ-specific response rate decreased as the size increased (13% for ⩽50 mm, 8.1% for 50–100 mm, and 5.5% for >100 mm). In the subgroup analysis according to tumor location, patients with lung only metastasis (⩾30 mm) showed the best progression-free survival (PFS) and overall survival (OS). In contrast, primary HCC (⩾100 mm) without lung metastasis had the worst PFS and OS. Comprehensive analyses also revealed that liver function and systemic inflammatory indices, such as neutrophil-to-lymphocyte ratio (NLR), were significantly associated with PFS and OS. Conclusion: The presence and size of liver tumors, liver function, and NLR are key factors determining the response to nivolumab in aHCC. These clinical factors should be considered when treating patients with advanced HCC with PD-1 blockade.
Transforming Primary Care in New York Through Patient-Centered Medical Homes: Findings From Qualitative Research
Authors: Weiss Linda , Griffin Kerry , Wu Meng , DeGarmo Ellie , Jasani Foram , Pagán José A. 
Published: July 2022

Background: The patient-centered medical home (PCMH) model, an important component of healthcare transformation in the United States, is an approach to primary care delivery with the goal of improving population health and the patient care experience while reducing costs. PCMH research most often focuses on system level indicators including healthcare use and cost; descriptions of patient and provider experience with PCMH are relatively sparse and commonly limited in scope. This study, part of a mixed-methods evaluation of a multi-year New York State initiative to refine and expand the PCMH model, describes patient and provider experience with New York State PCMH and its key components. Methods: The qualitative component of the evaluation included focus groups with patients of PCMH practices in 5 New York State counties (n = 9 groups and 67 participants) and interviews with providers and practice administrators at New York State PCMH practices (n = 9 interviews with 10 participants). Through these focus groups and interviews, we elicited first-person descriptions of experiences with, as well as perspectives on, key components of the New York State PCMH model, including accessibility, expanded use of electronic health records, integration of behavioral health care, and care coordination. Results: There was evident progress and some satisfaction with the PCMH model, particularly regarding integrated behavioral health and, to some extent, expanded use of electronic health records. There was less evident progress with respect to improved access and reasonable wait times, which caused patients to continue to use urgent care or the emergency department as substitutes for primary care. Conclusions: It is critical to understand the strengths and limitations of the PCMH model, so as to continue to improve upon and promote it. Strengths of the model were evident to participants in this study; however, challenges were also described. It is important to note that these challenges are difficult to separate from wider healthcare system issues, including inadequate incentives for value-based care, and carry implications for PCMH and other models of healthcare delivery.