bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of antimicrobial resistance awareness interventions involving schoolchildren, development of an animation and parents engagements: a pilot study
Authors: Appiah Bernard , Asamoah-Akuoko Lucy , Samman Elfreda , Koduah Augustina , Kretchy Irene Akwo , Ludu Julius Yaw , Odonkor Gloria , Nam Su Hyun , Gyansa-Luterrodt Martha 
Published: February 2022

Abstract
Background
Antimicrobial resistance (AMR) is a global health challenge, particularly in low- and middle-income countries where antibiotics are widely available to consumers, leading to their misuse. However, AMR educational interventions for engaging parents of schoolchildren are mainly lacking in Sub-Saharan Africa. This study aimed to assess the potential of AMR animation and schoolchildren in influencing parents’ AMR knowledge, attitudes, and beliefs.

Methods
Parents of schoolchildren aged 11–15 years in Tema, a city in Ghana, watched and discussed an AMR animation designed with ideas from the schoolchildren’s top stories and picture drawings. The children from two schools were first engaged with AMR lessons, with one school using storytelling, the other school using picture drawing, and none serving as a control. The children were then asked to discuss the lessons with their parents. Baseline surveys of parents of randomly selected children were conducted to assess AMR knowledge, attitudes and beliefs before engaging the students and parents, and immediately after the parents participated in viewing and discussing the animation. McNemar and t-tests were used to assess changes in AMR knowledge, attitudes and beliefs.

Results
Parents who participated in the animation event, and whose schoolchildren were in the storytelling intervention school had significantly improved knowledge regarding the statement “Antibiotics will cure any infection” (p = 0.021, χ2 = 0.711; 88% vs 50%) between baseline and endline. However, these parents also had statistically significant decreased scores regarding the statement “Antibiotics do not kill our good bacteria” (p = 0.021, χ2 = 1.042; 71.4% vs 40%) between baseline and endline. There was no significant effect on any statement among parents whose children were in the picture drawing school. However, t-test results combining the statements as composite scores showed statistically significant difference in only the attitude construct among parents whose children participated in storytelling intervention (p = 0.043) or picture drawing intervention (p = 0.019). There were no statistically significant changes in knowledge and beliefs constructs.

Conclusions
This study shows that interventions involving schoolchildren with parents engagements and AMR animation could influence parents’ AMR attitudes. The intervention could also positively or negatively impact parents’ AMR knowledge. Modifications of the interventions may be needed for tackling AMR.
Mathematics and science across the transition from primary to secondary school: a systematic literature review
Authors: Kaur Tandeep , McLoughlin Eilish , Grimes Paul 
Published: February 2022

AbstractThis study presents the findings from a systematic review of literature (1990–2020) of mathematics and science transition from primary to secondary education. The purpose of this review was to explore factors that influence students’ experiences of mathematics and science transition from primary to secondary school, implications of these experiences and measures that have been used to support students during these transitions. In total, 73 publications related to mathematics transition and 47 publications related to science transition were analysed. Synthesis of findings identified three factors, namely student self-regulation, school and academic related, and social factors that contribute to shaping students’ positive or negative experiences of mathematics and science transitions. The review findings suggest that no single factor can be attributed to influence students’ experiences of mathematics and science transition and an interplay between various factors contributes to these experiences. The implications of difficult transition experiences were identified as shifts in students’ academic achievement, attitudes towards mathematics and science and constructs related to identity development. Recommendations for future research are proposed to address gaps identified in current literature.
Effects of norepinephrine infusion on cerebral energy metabolism during experimental haemorrhagic shock
Authors: Jakobsen Rasmus Peter , Hansen Elisabeth Charlotte , Nielsen Troels Halfeld , Nordström Carl-Henrik , Toft Palle 
Published: February 2022

Abstract
Background
The use of norepinephrine in the case of life-threatening haemorrhagic shock is well established but widely discussed. The present study was designed to compare the effects of early norepinephrine treatment vs. no treatment on cerebral energy metabolism during haemorrhagic shock.

Methods
Twelve pigs were subjected to haemorrhagic shock, 4 in the control group and 8 in the norepinephrine (NE) group. Following a 60 min baseline period haemorrhagic shock was achieved by bleeding all animals to a pre-defined mean arterial blood pressure (MAP) of approximately 40 mm Hg. When mean arterial pressure had decreased to 40 mmHg NE infusion started in the treatment group. After 90 min, NE infusion stopped, and all pigs were resuscitated with autologous blood and observed for 2.5 h. During the experiment cerebral tissue oxygenation (PbtO2) was monitored continuously and variables reflecting cerebral energy metabolism (glucose, lactate, pyruvate, glutamate, glycerol) were measured by utilizing intracerebral microdialysis.

Results
All 12 pigs completed the protocol. NE infusion resulted in significantly higher MAP (p < 0.001). During the shock period lactate/pyruvate (LP) ratio group increased from 20 (15–29) to 66 (38–82) (median (IQR)) in the control group but remained within normal limits in the NE group. The significant increase in LP ratio in the control group remained after resuscitation. After induction of shock PbtO2 decreased markedly in the control group and was significantly lower than in the NE group during the resuscitation phase.

Conclusion
NE infusion during haemorrhagic shock improved cerebral energy metabolism compared with no treatment.
Use of Taguchi method for high energy ball milling of CaCO3
Authors: Radune Maya , Lugovskoy Svetlana , Knop Yaniv , Yankelevitch Avigdor 
Published: February 2022

AbstractTaguchi’s method was applied to investigate the effect of main high energy ball milling (HEBM) parameters: milling time (MT), ball to powder weight ratio (BPWR), and milling speed (MS) on the CaCO3 crystallite size. The settings of HEBM parameters were determined by using the L9 (33) orthogonal experiments array (OA). The as-received and milled powders were characterized by X-ray diffraction (XRD) scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy. The crystallite size of CaCO3 varied between 140 and 540 nm depending on the HEBM conditions. The analysis of variance (ANOVA) was used to find the significance and percentage of contribution of each milling parameter. It was established that the MT is the most effective parameter followed by MS and BPWR. A confirmation test was carried out with a 90% confidence level to illustrate the effectiveness of the Taguchi optimization method. The optimum milling parameter combination was determined by using the analysis of signal-to-noise (S/N) ratio. Based on the S/N ratio analysis, optimal HEBM conditions were found MT 10 h, MS 600 revolutions per minute (rpm), BPWR 50:1.
Improving management of needle distress during the journey to dialysis through psychological education and training—the INJECT study feasibility pilot protocol
Authors: Radisic G. , Duncanson E. , Le Leu R. , Collins K. L. , Burke A. L. J. , Turner J. K. , Chur-Hansen A. , Donnelly F. , Hill K. , McDonald S. , Macauley L. , Jesudason S. 
Published: February 2022

Abstract
Background
Needle-related distress is a common yet poorly recognised and managed problem among haemodialysis (HD) patients. The aim of this pilot study is to test the feasibility and acceptability of the INJECT Intervention—an innovative psychology-based intervention to empower patients to self-manage needle distress with the support of dialysis nurses.

Methods
This investigator-initiated, single-arm, non-randomised feasibility study will take place in a large dialysis service in Adelaide, Australia. Participants will include patients aged ≥ 18 years, commencing or already receiving maintenance HD, recruited through dialysis physicians and nursing staff as individuals believed to be at risk of needle distress. They will be screened for inclusion using the Dialysis Fear of Injection Questionnaire (DFIQ) and enrolled into the study if the score is ≥ 2. The multi-pronged intervention encompasses (i) psychologist review, (ii) patient self-management program and (iii) nursing education program. The primary aim is to evaluate feasibility and acceptability of the intervention from patient and dialysis nurse perspectives, including recruitment, retention, engagement with the intervention and completion. Secondary exploratory outcomes will assess suitability of various tools for measuring needle distress, evaluate acceptability of the nursing education program and measure cannulation-related trauma and vascular access outcomes.

Conclusion
The results will inform the protocol for larger trials addressing needle distress in HD patients.

Trial registration
Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12621000229875, approved 4 April 2021, https://www.anzctr.org.au/.
InSegtCone: interactive segmentation of crystalline cones in compound eyes
Authors: Tichit Pierre , Zhou Tunhe , Kjer Hans Martin , Dahl Vedrana Andersen , Dahl Anders Bjorholm , Baird Emily 
Published: February 2022

Abstract
Background
Understanding the diversity of eyes is crucial to unravel how different animals use vision to interact with their respective environments. To date, comparative studies of eye anatomy are scarce because they often involve time-consuming or inefficient methods. X-ray micro-tomography (micro-CT) is a promising high-throughput imaging technique that enables to reconstruct the 3D anatomy of eyes, but powerful tools are needed to perform fast conversions of anatomical reconstructions into functional eye models.

Results
We developed a computing method named InSegtCone to automatically segment the crystalline cones in the apposition compound eyes of arthropods. Here, we describe the full auto-segmentation process, showcase its application to three different insect compound eyes and evaluate its performance. The auto-segmentation could successfully label the full individual shapes of 60-80% of the crystalline cones and is about as accurate and 250 times faster than manual labelling of the individual cones.

Conclusions
We believe that InSegtCone can be an important tool for peer scientists to measure the orientation, size and dynamics of crystalline cones, leading to the accurate optical modelling of the diversity of arthropod eyes with micro-CT.
Mechanical obstruction of the peritoneal catheter with ovarian fimbriae, case reports
Authors: Jug Juraj , Kocman Ivica , Prkačin Ingrid 
Published: February 2022

AbstractThe number of treated patients with peritoneal dialysis accounts for 2.8% of all kidney replacement therapy methods and constantly decreases. Peritoneal dialysis should be the first choice as the kidney function replacement treatment method in a transplantation waiting period. Besides all other possible infectious and mechanical complications of peritoneal catheter placement and maintenance, mechanical obstruction by ovarian fimbriae is very rare but potentially dangerous. We present four clinical cases (women 32–56 years) of mechanical obstruction of the peritoneal catheter by ovarian fimbriae during 2012–2014 in Clinical Hospital Merkur, Zagreb, Croatia. We use a laparoscopic technique with Čala trocar for peritoneal catheter placement in the right part of the Douglas cavity using a double-cuff Tenckhoff straight catheter. In our cases, all described obstructions were on the right side of the abdominal cavity. Only one patient had a displaced catheter. This problem was described only in a few case reports in which were presented with fluid exchange difficulties or initial vaginal secretion which can be easily mistaken for urinary incontinence. Mechanical complications connected with a peritoneal catheter can be successfully solved with laparoscopy intervention, which includes the ovary fimbriae obstruction.
Cross-cultural differences in visuo-spatial processing and the culture-fairness of visuo-spatial intelligence tests: an integrative review and a model for matrices tasks
Authors: Gonthier Corentin 
Published: February 2022

AbstractVisuo-spatial reasoning tests, such as Raven's matrices, Cattell's culture-fair test, or various subtests of the Wechsler scales, are frequently used to estimate intelligence scores in the context of inter-racial comparisons. This has led to several high-profile works claiming that certain ethnic groups have lower intelligence than others, presumably due to genetic inferiority. This logic is predicated on the assumption that such visuo-spatial tests, because they are non-verbal, must be culture-fair: that their solution process does not significantly draw on factors that vary from one culture to the next. This assumption of culture-fairness is dubious at best and has been questioned by many authors. In this article, I review the substantial body of psychological and ethnographic literature which has demonstrated that the perception, manipulation and conceptualization of visuo-spatial information differs significantly across cultures, in a way that is relevant to intelligence tests. I then outline a model of how these inter-cultural differences can affect seven major steps of the solution process for Raven's matrices, with a brief discussion of other visuo-spatial reasoning tests. Overall, a number of cultural assumptions appear to be deeply ingrained in all visuo-spatial reasoning tests, to the extent that it disqualifies the view of such tests as intrinsically culture-fair and makes it impossible to draw clear-cut conclusions from average score differences between ethnic groups.
Effects of verbal tasks on driving simulator performance
Authors: Rann Jonathan C. , Almor Amit 
Published: February 2022

AbstractWe report results from a driving simulator paradigm we developed to test the fine temporal effects of verbal tasks on simultaneous tracking performance. A total of 74 undergraduate students participated in two experiments in which they controlled a cursor using the steering wheel to track a moving target and where the dependent measure was overall deviation from target. Experiment 1 tested tracking performance during slow and fast target speeds under conditions involving either no verbal input or output, passive listening to spoken prompts via headphones, or responding to spoken prompts. Experiment 2 was similar except that participants read written prompts overlain on the simulator screen instead of listening to spoken prompts. Performance in both experiments was worse during fast speeds and worst overall during responding conditions. Most significantly, fine scale time-course analysis revealed deteriorating tracking performance as participants prepared and began speaking and steadily improving performance while speaking. Additionally, post-block survey data revealed that conversation recall was best in responding conditions, and perceived difficulty increased with task complexity. Our study is the first to track temporal changes in interference at high resolution during the first hundreds of milliseconds of verbal production and comprehension. Our results are consistent with load-based theories of multitasking performance and show that language production, and, to a lesser extent, language comprehension tap resources also used for tracking. More generally, our paradigm provides a useful tool for measuring dynamical changes in tracking performance during verbal tasks due to the rapidly changing resource requirements of language production and comprehension.
The optimal use of computer aided detection to find low prevalence cancers
Authors: Kunar Melina A. 
Published: February 2022

AbstractPeople miss a high proportion of targets that only appear rarely. This low prevalence (LP) effect has implications for applied search tasks such as the clinical reading of mammograms. Computer aided detection (CAD) has been used to help radiologists search mammograms by highlighting areas likely to contain a cancer. Previous research has found a benefit in search when CAD cues were correct but a cost to search when CAD cues were incorrect. The current research investigated whether there is an optimal way to present CAD to ensure low error rates when CAD is both correct and incorrect. Experiment 1 compared an automatic condition, where CAD appeared simultaneously with the display to an interactive condition, where participants could choose to use CAD. Experiment 2 compared the automatic condition to a confirm condition, where participants searched the display first before being shown the CAD cues. The results showed that miss errors were reduced overall in the confirm condition, with no cost to false alarms. Furthermore, having CAD be interactive, resulted in a low uptake where it was only used in 34% of trials. The results showed that the presentation mode of CAD can affect decision-making in LP search.
Reversible occlusion of the pulmonary vasculature by transarterial embolisation with degradable starch microspheres: preclinical assessment in a human isolated lung perfusion model
Authors: Schaarschmidt Benedikt M. , Slama Alexis , Collaud Stéphane , Okumus Özlem , Steinberg Hannah , Bauer Sebastian , Schildhaus Hans-Ulrich , Theysohn Jens , Aigner Clemens 
Published: February 2022

Abstract
Background
Transpulmonary embolisation (TPE) using degradable starch microspheres (DSM) is a potential approach to treat pulmonary metastases. However, there is a paucity of detailed information on perfusion dynamics. The aim of this study was to establish a human ex vivo isolated lung perfusion (ILP) model to observe and evaluate the effects of DSM-TPE in a near-physiologic setting.

Methods
ILP was carried out on six surgically resected lung lobes. At baseline, computed tomography (CT), including CT perfusion imaging (CTPI), and histopathological sampling were performed (t30). DSM-TPE was initiated and increased stepwise (t45, t60, t75, and t90) to be followed by CT imaging, histopathological sampling, and pulmonary arterial pressure (PAP). After the last assessment (t90), alpha-amylase was injected into the pulmonary artery to allow for DSM hydrolysation and two additional assessments (t105; t120). Histopathological specimens were evaluated using a semiquantitative ordinal score. CTPI was used for time to peak (TTP) analysis.

Results
After DSM administration, PAP and TTP increased significantly: PAP slope 95% confidence interval (CI) 0.104−0.483, p = 0.004; TTP t30 versus t45, p = 0.046. After the addition of alpha-amylase, functional parameters reverted to values comparable to baseline. In histopathological samples, embolisation grades increased significantly until t90 (slope 95% CI 0.027−0.066, p < 0.001) and decreased after addition of alpha-amylase (slope 95% CI -0.060−0.012, p = 0.165),

Conclusions
The ILP model demonstrated successfully both the physiologic effect of DSM-TPE on human lungs and its reversibility with alpha-amylase. Thus, it can be used as a near-physiologic preclinical tool to simulate and assess later clinical approaches.
Oral mucosal lesions during SARS-CoV-2 infection: a case series and literature review
Authors: Mahmoud Mohammad Salah , Taha Mohamed Shehata , Mansour Ossama Ibrahim , Barakat Eman , Allah Samar Abd , Omran Azza , Askoura Anas 
Published: February 2022

Abstract
Background
The most common manifestations of infection with COVID-19 are fever, sore throat, dry cough, headache, and body aches. The available evidence for successful and safe pharmacological therapy against COVID-19 has not yet been identified, and the possible evidence relates to many adverse reactions. Taste disorders, petechiae, desquamative gingivitis, unspecific oral ulcerations, xerostomia, and candidiasis are the oral manifestations related to SARS-CoV-2 infection.

Main body of the abstract
We reviewed the literature regarding the reported oral mucosal lesions in cases with confirmed COVID-19 infection together with presenting five cases with oral mucosal lesions associated with COVID-19 infection. Direct causal association between COVID-19 infection and oral mucosal lesions is still vague, hence further research is required.

Conclusion
Oral examination is mandatory in cases with suspected or confirmed COVID-19 infection.
Evaluation method of hydrocarbon yield of source rocks in open, semiopen, and closed systems: A case study on the K1qn Formation, northern Songliao Basin, China
Authors: Wang Wenguang , Wang Min , Lu Shuangfang , Lin Chengyan , Zheng Min 
Published: February 2022

Hydrocarbon yield of source rocks is an important parameter in the evaluation of oil and gas resources, and its value determines the potential of conventional and unconventional oil and gas resources. There is no oil cracking into gas in the thermal pyrolysis experiment data of an open system, whereas kerogen cracking into oil in a closed system is involved in the calculation of oil cracking into gas. However, most source rocks in sedimentary basins are a process of hydrocarbon generation and hydrocarbon expulsion, which could lead to insufficient understanding of hydrocarbon yield of source rocks. Based on the multiple thermal pyrolysis experiment data, three hydrocarbon generation kinetic models, and actual geologic data (burial history, thermal history, and hydrocarbon generation threshold), we established the evaluation method and chart of hydrocarbon yield of source rocks under open, semiopen, and closed systems by using the hydrocarbon generation kinetics method. The concept of degree of openness was proposed. From a closed system to an open system, the degree of openness increases gradually, and its value changes from 0 to 1. Taking the K1qn Formation in the northern Songliao Basin as an example, the hydrocarbon expulsion efficiency of the K1qn Formation source rock is approximately 70%, and it can be approximated as the degree of openness. Based on our method for evaluating hydrocarbon yield of source rocks, the charts of hydrocarbon yield of source rocks under open system, semiopen system with a degree of openness of 0.7, and closed system of the K1qn Formation in the northern Songliao Basin were established. The oil and gas yields of the K1qn Formation source rocks in a semiopen system with a degree of openness of 0.7 are approximately 540 and 105 mgHC/gTOC at a burial depth of 2000 m, respectively. Our results indicate that the hydrocarbon yield of source rocks in a semiopen system is closer to the hydrocarbon yield of source rocks under geologic condition. We use the thermal pyrolysis experiment data, hydrocarbon generation kinetics model, and geologic data to propose a very valuable evaluation method of hydrocarbon yield of source rock, which has a solid theoretical basis and strong applicability.