bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do students of dance schools show orthorexic behaviours?
Authors: Grajek Mateusz , Krupa-Kotara Karolina , Białek-Dratwa Agnieszka , Sas-Nowosielski Krzysztof 
Published: March 2022

Abstract
Introduction. Many studies have shown that a group of people practicing sports, including those representing sports disciplines that require a slim figure and flexibility, is exposed to an increased risk of orthorexia nervosa (ON). Due to great difficulties in making the final diagnosis, the exact number of people suffering from orthorexia is still unknown. Aim. The study aimed to assess the risk of orthorexic behavior in the group of girls attending ballet schools. The essence of the study was to analyze the anthropometric indicator and eating habits and to correlate them with the obtained risk indicator of orthorexic behaviors. Material and method. The investigated group consisted of 800 female students (10–18 years old) who attended ballet schools in Poland (Silesia). At the beginning of the study, anthropometric measurements of the examined students were performed and a detailed nutritional interview was conducted with them. The dietary habits of the research group were evaluated by the diet quality index (DQI) . To assess the risk of orthorexic behaviors, an ORTO-15, and ORTO-15 PL questionnaires were used. The collected data were statistically analyzed (the Statistica 13.0 package was applied). The degree of probability was 0.05. Results. Based on the DQI it was found that 44% of all respondents reported good, 36% - satisfactory, and 20% - bad eating habits. The genuine risk of eating disorders was observed among 65% (ORTO-15) and 59% (ORTO-15 PL) of subjects. This included students with good dietary habits (65%) and 73% of students who considered themselves to be obese. Statistical inference showed a relationship between the positive result obtained in the ORTO-15 questionnaire and participants’ incorrect perception of their own body (p<0.05). Moreover, it was noted that higher scores in both ORTO scales were obtained by girls whose BMI (62%) and %BF (56%) were in the correct range. Conclusion. This is particularly visible in the group of girls whose eating habits were assessed as good and in the group of ballerinas who consider themselves obese. Moreover, it was noted that BMI and adipose tissue level in the risk group was at the correct level.
Using Population Health Management to improve screening of women with history of gestational diabetes in an urban setting
Authors: Bridle Laura , Cross Pauline , Danielli Shaun , Ashrafian Hutan , Darzi Ara 
Published: March 2022

Abstract
Background The human and financial costs of diabetes related illness and treatment are significant and increasing. This is also true of women who develop gestational diabetes in pregnancy, the majority of which are subsequently likely to develop type 2 diabetes. The National Institute for Health & Care Excellence (NICE) guidance sets out clear expectations of the care pregnant women should receive. However, evidence suggests reality is a long way from this guidance. Methods Data was collected from the population health management system covering the London borough of Lewisham. This was used to compare actual care with NICE guidance. The results were used to target cultural appropriate interventions to improve care. ResultsThe care pregnant women were receiving fell a long way short of NICE guidance, with 84% of women not being screened at the initial 3 months postpartum and 99% of women not being screened annually. This is significantly worse than the UK average. ConclusionUsing population health management is beneficial in identifying the gap between actual care and best practice. The process of examining the data through population health management also enable targeted culturally appropriate interventions.
Predictive role of Ubiquitin-conjugating enzyme E2T in recurrence-free survival and aromatase inhibitor responsiveness in breast cancer
Authors: Zhang Wei , wang Siying , Zhang Ruiqi , Qu Shaohua , Lyu Jun , Lyu Rongzhao , Wang Ningxia 
Published: March 2022

Abstract
Background: Ubiquitin-conjugating enzyme E2T (UBE2T), an E2 ubiquitin-conjugating enzyme, is verified to play an important role in the tumorigenesis of various cancers. By downregulation of BRCA1, UBE2T affects the growth of BC cells. However, the clinical significance of UBE2T is uncertain. To explore the role of UBE2T in breast cancer (BC). Methods: Firstly, we analyzed the correlations between UBE2T and clinicopathological characteristics of BC by the TCGA database. Next, Cox regression and Kaplan-Meier analysis were utilized for association between clinicopathological features and the overall survival (OS). Kaplan-Meier analysis and ROC plotter were used for survival analysis and drug sensitivity. Results：UBE2T was significantly upregulated in BC in comparison with para cancer tissue(p<0.001). The high expression of UBE2T is related to lager tumor sizes (p=0.006) and later clinical stages (p=0.001). UBE2T is verified to be correlated with ER, PR, HER2 status of BC. The expression level of UBE2T varies in different molecular subtypes of BC. Further research revealed that UBE2T mainly affected the recurrence-free time of BC in subgroups. Conclusions: Univariate analysis and multivariate analysis certified that UBE2T was an independent indicator for BC prognosis. UBE2T is proven to be a good biomarker for predicting the responds of BC patients to aromatase inhibitor (AI).
Design and Development of RTI System for Moisture Content Localization in Rice Silo
Authors: ABDULLAH MOHAMMED SAEED MOQBEL , Rahiman Mohd Hafiz Fazalul , Zakaria Ammar , Kamarudin Latifah Munirah , Mohamed Latifah , Ramli Nurul Amira , Talib Masturah Tunnur Mohamad , Lee Chau Ching , Ahmad Anita , Rahim Ruzairi Abdul 
Published: March 2022

Abstract
Moisture content (MC) is the weight of water contained in rice and other grains expressed in percent. Accurate MC testing is essential for managing and selling the paddy and rice, depending on the marketing goals. Inaccurate MC measurement leads to lower head rice, extra drying cost, and a loss of quality, whereas spoilage and harvesting losses if the paddy is harvested wetter than necessary. Currently, the assessment of rice MC is based on a sampling and single point measurement, and so far, there is no available method for the overall measurement of the MC in a rice silo. This research intends to reconstruct a Radio Tomography Imaging (RTI) of the rice MC. By using the tomography method, one can assess the rice MC in the whole silo. The efficiency and accuracy of the localization of moisture distribution in the rice silo can be investigated by mapping the strong and weak received signal strength (RSS), where different colors in the tomogram represent the changes in moisture distribution. The mapping of the RSS in terms of RTI tomogram was reconstructed by three proposed image reconstruction algorithms which are linear back projection, filtered back projection and Gaussian. In this study, eight different phantoms' position and size have been tested. The reconstructed images were analyzed using the Mean Structural Similarity Index (MSSIM). Gaussian algorithm scored the highest MSSIM index for all phantoms' features. In conclusion, this study offered a new finding on the tomography approach to localize the rice MC in a whole silo.
The Distribution and Drug Resistance Characteristics of Methicillin Resistant Staphylococcus aureous to be Public and Animal Health Burdon in Ethiopia: Meta-Analysis
Authors: Fayissa Negassa , Alemu Tesfaye , Desalegn Asnake , Jirata Dagim 
Published: March 2022

Abstract
Introduction: Antimicrobial resistance to specific antibacterial drugs in bacteria have led many drugs of choice ineffective against pathogens. Methecillin resistant S.aureus (MRSA) is one of the pathogens, which looses sensitivity to Methicillin. Methicillin has been considered as the drug of choice of choice to treat infections caused by β-lactams and other antibiotics resistant S. aureus. Objectives: The objectives of the current study were to analyse the prevalence of MRSA in S. aureus isolates from different sources of samples and to assess the risk factors associated with the prevalence. The multidrug resistance pattern of the pathogen was also one of the outcome of interest of the review.Methods: The original research articles were collected from PubMed and PMC databases from 12th to 14th December 2021. The English language articles conducting on MRSA prevalence in Ethiopia were included in the analysis. Relevant data were extracted, coded and displayed on Excel spreadsheet. The pooled prevalence of MRSA was determined per S. aureus isolates. The analysis were made by using R statistical software at 95% CI. Result: 79 research eligible articles were selected for the meta-analysis. 26930 samples were collected from different sampled materials. Of these 4219 (15.65%) were S. aureus positive of which 1695 were found MRSA strains. The overall pooled prevalence of MRASA in S. aureus was found to be 40%. The pooled prevalence of MRSA in human, animal, food and environment was 38%,15%,77%,and 54% respectively. The strain was determined significantly highest in food and environment than in animal and human samples (p<0.05). The subgroup analysis based on the health status of the individual in samples of human indicated that MRSA was significantly prevalent in patients than in health individuals (p<0.05). The assessment of MDR pattern of MRSA revealed that it was highly resistant to cefuroxime (100%), Tobramycin (100%), Neomycin (99%) and Penicillin (92%), Pipracilin (91%), Erythromycin (88%), Bacitracin(84%) and Amoxacilin-clavulanicacid (80%). In contrast Clindamycin, chloramphenicol, Amikacin, vancomycin, Knamycin and Ceftriaxone with pooled resistance rates of 21%, 22%, 27% , 20%, 25% and 30% respectively were antibiotic of relatively better effective.
Efficacy of Alternating Antipyretic Therapy According to the Administration Interval in Children Using Patient-Generated Health Data: A Retrospective Observational Study
Authors: Kim Hyery , Na Se Hee , Park Ji Ae , Sung Min Dong , Lee Jae-Ho , Shin Jae Won , Park Yu Rang 
Published: March 2022

Abstract
Caregivers are often advised to use additional antipyretic agents if fever persists before the next dosing time. However, no consistent evidence or guidelines have been reported. This study was to evaluate appropriate time intervals for alternating antipyretic therapy based on the antipyretic effect and incidence of low body temperature using large-scale patient-generated health data. Participants were children and their caregivers, who used the Fever Coach mobile application between February 2015 and December 2019. One case was referred to as a single record for up to 72 h after the first antipyretic record. Of the total 138,117 cases, the mean age was 29.58 months, and the mean baseline temperature was 38.77°C. The reduction in body temperature from baseline was -0.33°C, -0.54°C, and -0.62°C in the 2-3 hours, 3-4 hours, and 4-5 hours interval groups, respectively (P<.001, effect size 0.041). Within 6 hours, the area under the temperature curve from baseline was -201.59 in the 2-3 hours interval, -165.62 in the 3-4 hours interval, and -164.32 in the 4-5 hours interval groups (P<.001, effect size 0.014). In this study using large-scale patient-generated health data, antipyretic effects were greatest at the 2-3 hours interval for alternating therapy. Digitalized patient-generated health data could be used as a proper reference for real-world health guidelines.
In vitro anti-inflammatory compounds from Viburnum coriaceum show inhibition of epileptic seizures in rat model
Authors: Vijayakumar Vijaytha , Jayanandan Abhithaj , Mrudhula C. , Suresh Sharanya C. , Sabu A. , Variyar E. Jayadevi , Haridas M. 
Published: March 2022

Abstract
Inflammatory mediators released during seizure act as neuromodulators for nerve cell functioning along with inflammation build-up. They can be targeted for the treatment of epilepsy. Anticonvulsant activity of Viburnum coriaceum extract suggested the potential of the plant in neurological disorders. Preliminary analysis revealed the inhibitory potential of plant root-hexane extract on trypsin and LOX in vitro. This was then fractionated by various chromatographic techniques for the isolation of active compounds. In silico scrutiny of compounds in the GC profile revealed two active compounds, docosane, and methyl palmitate. These compounds were subjected to trypsin and LOX inhibition and their kinetics assays, LOX and COX inhibition assays in LPS induced inflammatory IMR 32 cell lines, and antiepileptic activity on pilocarpine-induced rat models. Docosane showed 50.74% trypsin and 82.51% LOX inhibition. Methyl palmitate showed 91.04% trypsin and 81.12% LOX inhibition. Both the compounds showed a mixed mode of inhibition for trypsin. Docosane showed a mixed-mode and methyl palmitate showed an uncompetitive mode of inhibition for LOX. In the cell culture studies, methyl palmitate had 75.25% and docosane had 67.66% inhibition on COX whereas they had 72.97% and 67.22% inhibition on LOX respectively. Methyl palmitate showed a better antiepileptic activity on rat models.
Gradient of the First Order Reduced Density Matrix. A Look at two Charge-Shift Bonds
Authors: Hernández-Lechuga Karem , Hernández-Pérez Julio-Manuel , Ho Minhhuy 
Published: March 2022

Abstract
This article reports a generalization of the study of the 1-RDM cut along the bond axis for polyatomic molecules; the use of its gradient to partition 1-RDM maps into regions that are directly related to atomic orbital interactions. Gradient maps of various diatomics reveal insights that are not apparent in the 1-RDM or density maps. Studies of two charge-shift bonds show that although the two share common features, there are important differences that are not detected neither by density based analysis nor valence bond theory. The results suggest the gradient of 1-RDM as a valuable tool in bond analysis.
Surrounded by Concrete: Genetic Isolation of Tillandsia Recurvata L. in an Urban Landscape in South-Eastern Brazil
Authors: Quail Megan Rhianne , Ramos Flavio Nunes , Dallimore Thom , Ashton Paul , Clayton-Brown Jennifer , Provan Jim , Batke Sven Peter 
Published: March 2022

Abstract
Increasing urban expansion has resulted in the decline of many natural and semi-natural communities globally. However, the connectivity and genetic structure of species that survive in these urban landscapes has received little attention, especially with regard to epiphytic plants. The aims of this study were to 1) investigate how an urban landscape can impact the connectivity and genetic structure of Tillandsia recurvata, L., a highly abundant and widely distributed atmospheric epiphyte; to 2) understand what the driving landscape factors are that affects connectivity and structure; and to 3) discuss how urbanisation can affect genetic structure in epiphytes. A total of 288 T. recurvata individuals were sampled across 65 trees throughout the city of Alfenas in South-East Brazil. We designed seven novel microsatellite markers and used four cross-amplified loci to determine the basic genetic structure of T. recurvata. All populations showed high global spatial genetic structure (SGS) and population differentiation. The high SGS of T. recurvata indicated low connectivity between urban populations, with strong evidence to suggest that this was the result of small population size and genetic drift. Pasture trees outside of the urban landscape are likely to be an important source of gene flow to isolated urban epiphyte populations. This study represents an important step towards understanding epiphyte population structure within urban landscapes. Low connectivity across urban landscapes is likely to benefit epiphytes such as T. recurvata due to their adaptability and high tolerance; suggesting a bleak future for many other more sensitive epiphyte species under predicted urbanisation globally.
Surgical Apgar score is significantly useful as a predictor of major complications after thoracic spinal surgery: a retrospective cohort study
Authors: Shibao Yosuke , Miura Kousei , Koda Masao , Asada Tomoyuki , Sato Kosuke , Eto Fumihiko , Kono Mamoru , Mataki Kentaro , Kumagai Hiroshi , Nagashima Katsuya , Noguchi Hiroshi , Takahashi Hiroshi , Funayama Toru , Tatsumura Masaki , Yamazaki Masashi 
Published: March 2022

Abstract
Background: Prediction of postoperative complications and management based on that prediction are important for improving outcomes. The surgical Apgar score, a simple score for surgical outcomes, has been used to predict postoperative complications. The purpose of this study was to investigate the usefulness of the surgical Apgar score to predict major complications after thoracic spinal surgery. Methods: The subjects were 104 patients who underwent thoracic spinal surgery at a single institution from 2014 to 2018. Background patient and disease characteristics assessed included age, gender, body mass index (BMI), comorbidities (diabetes, hypertension or coronary artery disease), anticoagulant and antiplatelet medications, preoperative hemoglobin, controlling nutritional status (CONUT) score, and American Society of Anesthesiologists-Physical Status (ASA-PS) classification. Surgical factors evaluated were operative time, approach, presence of instrumentation, and multiple intervertebral surgery. The surgical Apgar score was calculated from intraoperative estimated blood loss, minimum heart rate, and minimum mean blood pressure. Major complications were defined as unexpected elongation of intubation for more than 48 hours, postoperative blood transfusion (bleeding) of more than 4U in 72 hours, coronary artery disease, renal failure, cerebrovascular disease, sepsis, pneumonia, severe delirium, deep vein thrombosis, pulmonary embolism (PE), or wound complications. Postoperative hospitalization days were also investigated. A multivariate statistical analysis was performed using stepwise logistic regression. The occurrence of complications and the duration of postoperative hospitalization were compared using a t-test. A p-value of <0.05 was considered significant.Results: Major complications were observed in 19 (18.3%) patients; these were bleeding (8 patients), delirium and wound complications (4 patients each) PE (2 patients) and pneumonia and acute kidney injury (1 patient each). The multivariate analysis revealed that the surgical Apgar score (odds ratio=0.3) was significantly associated with major complications. Postoperative hospital stay was significantly longer in patients with complications (59 days) than in patients without complications (36 days; p=0.0015).Conclusion: The surgical Apgar score is an objective index that can be easily calculated from anesthesia records, and this study suggests that it may be useful in predicting major complications after thoracic spinal surgery.
Face, Content, and Construct Validity Evaluation of Simulation Models in General Surgery Laparoscopic Training and Education: A Systematic Review.
Authors: Rueda-Esteban Roberto Javier , Lopez-McCormick Juan Sebastian , Rodriguez-Bermeo Stefania , Andrade Mateo , Hernández Juan David , Targarona Eduardo M 
Published: March 2022

Abstract
Background: Laparoscopic technical surgical skills (LTS) are considered a fundamental competence for General Surgery residents. Several simulation tools (ST) have been explored to develop these skills. Although a plethora of systematic reviews evaluate the translation of LTS developed in simulation to real surgery, there is a lack of evidence that clarifies effectiveness of different validated ST in acquisition of LTS in surgical residents. The aim of this systematic review (SR) is to summarize current published evidence on ST validation used for general surgery education and training.Methods: An initial protocol was published in PROSPERO, under registration number: CRD42020205397. A SR of the literature was carried out following PRISMA guidelines. Complete published articles in English or Spanish that validate either content or construct, plus another form of validation of ST to acquire LTS in general surgery were included. Articles that used only one validation strategy or did not validate an ST were excluded.Results: 1052 publications were initially identified across all searched databases. Title review identified 204 studies which were eligible for full text screening. 10 studies were included for final review. Two studies assessed both face and content, four face and construct, and four face, content and construct validity. None of the studies presented comparable outcomes due to metrics variation and scores used for the validation strategies.Conclusions: This study assessed validated laparoscopic simulation models, with particular interest in content and construct validity. Articles reported an increased use of simulation models in laparoscopic training with positive feedback from trainees, but few studies reported validation of training model. Validation strategies are not standardized, limiting comparability between them.
Impact of COVID-19 Epidemic on the Incidence and Mortality of Tuberculosis by Regions in Taiwan
Authors: Lin En-Cheng , Hong Chien-Hui 
Published: March 2022

Abstract
Tuberculosis (TB) remains a significant health and public issue in many countries. Its incidence and mortality have been decreasing in many countries. The recent COVID-19 could have significant impacts on the transmission and health care for this chronic disease by obligatory facial masking and by affecting healthcare capacities. We asked whether the trend of TB incidence and mortality would be affected by COVID-19 epidemic due to their common air transmission route. We also asked whether the incidence of TB in regions with different COVID-19 incidence would be similar. We obtained the annular new cases of TB and multi-drug resistant TB through Taiwan CDC and estimated the incidence and mortality by the population numbers in 7 administrative regions in Taiwan in 2011–2021. The result showed that incidences of TB and multi-drug resistant TB in recent 10 years show a continuously decreasing trend, even amid the COVID-19 epidemic in 2020-21. In addition, the mortality of TB shows similar decreasing trend in 2020-21. From 2011–2011, the highest incidence of TB was in the southern and eastern Taiwan whereas the lowest incidence of TB was in northern Taiwan. In contrast, the highest incidence of COVID-19 in 2020-21 was in the northern Taiwan while the lowest incidence of COVID-19 in 2020-21 is in the southern and eastern Taiwan. These results indicated that in the low COVID-19 incidence regions of Taiwan, the incidence of TB remained high during COVID-19 pandemic. We concluded that the decreasing trend of incidence and mortality of TB does not change during COVID-19 epidemic in Taiwan. The mask wearing and social distancing could prevent the transmission of COVID-19, however, their effect on the limiting spread of TB may be limited.