bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lung Ultrasound Signs and Their Correlation With Clinical Symptoms in COVID-19 Pregnant Women: The “PINK-CO” Observational Study
Authors: Vetrugno Luigi , Sala Alessia , Orso Daniele , Meroi Francesco , Fabbro Sebastiano , Boero Enrico , Valent Francesca , Cammarota Gianmaria , Restaino Stefano , Vizzielli Giuseppe , Girometti Rossano , Merelli Maria , Tascini Carlo , Bove Tiziana , Driul Lorenza ,   The PINK-CO study investigators
Published: June 2022

ObjectiveTo analyze the application of lung ultrasound (LUS) diagnostic approach in obstetric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and compare LUS score and symptoms of the patients.DesignA single-center observational retrospective study from October 31, 2020 to March 31, 2021.SettingDepartment of Ob/Gyn at the University-Hospital of Udine, Italy.ParticipantsPregnant women with SARS-CoV-2 diagnosed with reverse transcription-PCR (RT-PCR) swab test were subdivided as symptomatic and asymptomatic patients with COVID-19.ExposureLung ultrasound evaluation both through initial evaluation upon admission and through serial evaluations.Main OutcomeReporting LUS findings and LUS score characteristics.ResultsSymptomatic patients with COVID-19 showed a higher LUS (median 3.5 vs. 0, p &lt; 0.001). LUS was significantly correlated with COVID-19 biomarkers as C-reactive protein (CPR; p = 0.011), interleukin-6 (p = 0.013), and pro-adrenomedullin (p = 0.02), and inversely related to arterial oxygen saturation (p = 0.004). The most frequent ultrasound findings were focal B lines (14 vs. 2) and the light beam (9 vs. 0).ConclusionLung ultrasound can help to manage pregnant women with SARS-CoV-2 infection during a pandemic surge.Study RegistrationClinicalTrials.gov, NCT04823234. Registered on March 29, 2021.
Acanthocytes Identified in Huntington’s Disease
Authors: Yu Yueyi , Lu Yuanyuan , Wang Fen , Lu Yan , Xie Beijia , Meng Xiaosheng , Tang Yi 
Published: June 2022

BackgroundNeuroacanthocytosis (NA) and Huntington’s disease (HD) are neurodegenerative conditions that share clinical symptoms and imaging findings, despite their distinct genetic etiologies. Usually, the presence of acanthocytes can help narrow the differential diagnosis of a familial choreiform disorder, as the diagnosis of NA syndrome is supported by the presence of acanthocytes in peripheral blood. In this study, we demonstrate four patients who present with HD and acanthocytosis.MethodsWe retrieved the data of 40 HD patients with fresh peripheral blood screened for erythrocytes in our hospital from 2014 to 2022. Of these 40 patients, four patients with acanthocytes were recruited for this study. Patients’ investigations included clinical and laboratory studies, HTT gene sequencing, and whole-exome sequencing. Fresh peripheral blood was screened for erythrocytes by scanning electron microscopy.ResultsThe four adult patients were Han Chinese and unrelated. The age ranged from 45 to 61 years, with a disease duration of 4–10 years. The main neurological features at diagnosis included progressive involuntary movements, psychiatric changes, and dementia. Genetic analysis showed an expansion at the HTT gene. The mean proportion of acanthocytes was mild (6–10%) elevated in patient one and high (&gt;20%) elevated in patients 2–4 by scanning electron microscopy examination.ConclusionOur study illustrates that HD can combine with acanthocytosis, which may expand the clinical phenotype. Even though the primary gene defect appears to be predominately directed at the brain, a peripheral defect can be seen in HD. Our study highlights the complexity and diversity of HD.
A Simplified Herbal Formula Improves Cardiac Function and Reduces Inflammation in Mice Through the TLR-Mediated NF-κB Signaling Pathway
Authors: Dong Xiaoming , Han Xiaowei , Zhang Xiaojiao , Li Sijing , Li Ziru , Kang Jinhua , Jiang Jialin , Ni Shihao , Lu Lu , He Zhiling , Huang Haoming , Xian Shaoxiang , Yuan Tianhui , Yang Zhongqi , Long Wenjie , Wan Zemin 
Published: June 2022

Nuanxinkang tablet (NXK), a Chinese herbal formula, can improve heart function and quality of life in patients with chronic heart failure (CHF). However, the mechanisms of action of NXK are not fully understood. In this study, we investigated the effects of NXK on inflammation in the CHF mouse model. This model was established by transverse aortic constriction (TAC) and treated with NXK for 8 weeks. Then, the cardiac function and myocardial fibrosis were evaluated. The monocytes/macrophages were evaluated by immunofluorescence. The mRNA levels of IL-1β, IL-6, TNF-α, ICAM-1, and VCAM-1 were measured by quantitative real-time polymerase chain reaction (qRT-PCR), while TLR4, MyD88, NF-κB p65, P-IκBα, TLR2, TLR7 and TLR9 protein levels were evaluated by Western blot. The results showed that NXK improved the left ventricular ejection fraction (LVEF) and left ventricular end-systolic dimension, reversed myocardial fibrosis, and inhibited pro-inflammatory (CD11b + Ly6C+) monocytes/macrophages in the TAC mouse model. NXK also reduced the mRNA and protein levels of the above markers. Taken together, NXK improved heart function and reduced inflammation through the TLR-mediated NF-κB signaling pathway, suggesting that it might be used as an innovative treatment strategy for CHF.
Acute Effects of Barbell Bouncing and External Cueing on Power Output in Bench Press Throw in Resistance-Trained Men
Authors: Saeterbakken Atle Hole , Loken Jorund , Solstad Tom Erik Jorung , Stien Nicolay , Prieske Olaf , Scott Suzanne , Andersen Vidar 
Published: June 2022

The aims of this study were to compare power output during a bench press throw (BPT) executed with (BPTbounce) and without (BPT) the barbell bounce technique, and examine the effect of cueing different barbell descent velocities on BPT power output in resistance-trained males. In total, 27 males (age 23.1 ± 2.1 years; body mass 79.4 ± 7.4 kg; height 178.8 ± 5.5 cm; and 4.6 ± 1.9 years of resistance training experience) were recruited and attended one familiarization session and two experimental sessions (EXP 1 and EXP 2). The force–velocity profile during maximal BPT and BPTbounce (randomized order) under different loads (30–60 kg) was established (EXP 1), and the effect of varying external barbell descent velocity cues “slow, medium, and as fast as possible” (i.e., “fast”) on the power output for each technique (BPT and BPTbounce) was examined (EXP 2). Comparing two BPT techniques (EXP 1), BPTbounce demonstrated 7.9–14.1% greater average power (p ≤ 0.001, ES = 0.48–0.90), 6.5–12.1% greater average velocity (p ≤ 0.001, ES = 0.48–0.91), and 11.9–31.3% shorter time to peak power (p ≤ 0.001–0.05, ES = 0.33–0.83) across the loads 30–60 kg than BPT. The cueing condition “fast” (EXP 2) resulted in greater power outcomes for both BPT and BPTbounce than “slow.” No statistically significant differences in any of the power outcomes were observed between “medium” and “slow” cuing conditions for BPT (p = 0.097–1.000), whereas BPTbounce demonstrated increased average power and velocity under the “medium” cuing condition, compared to “slow” (p = 0.006–0.007, ES = 0.25–0.28). No statistically significant differences were observed in barbell throw height comparing BPT and BPTbounce under each cuing condition (p = 0.225–1.000). Overall, results indicate that both bouncing the barbell and emphasizing barbell descent velocity be considered to improve upper body power in athlete and non-athlete resistance-training programs.
Nuclear Receptors (PPARs, REV-ERBs, RORs) and Clock Gene Rhythms in Goldfish (Carassius auratus) Are Differently Regulated in Hypothalamus and Liver
Authors: Gómez-Boronat Miguel , De Pedro Nuria , Alonso-Gómez Ángel L. , Delgado María J. , Isorna Esther 
Published: June 2022

The circadian system is formed by a network of oscillators located in central and peripheral tissues that are tightly linked to generate rhythms in vertebrates to adapt the organism to the cyclic environmental changes. The nuclear receptors PPARs, REV-ERBs and RORs are transcription factors controlled by the circadian system that regulate, among others, a large number of genes that control metabolic processes for which they have been proposed as key genes that link metabolism and temporal homeostasis. To date it is unclear whether these nuclear receptors show circadian expression and which zeitgebers are important for their synchronization in fish. Therefore, the objective of this study was to investigate whether the two main zeitgebers (light-dark cycle and feeding time) could affect the synchronization of central (hypothalamus) and peripheral (liver) core clocks and nuclear receptors in goldfish. To this aim, three experimental groups were established: fish under a 12 h light-12 h darkness and fed at Zeitgeber Time 2; fish with the same photoperiod but randomly fed; and fish under constant darkness and fed at Circadian Time 2. After one month, clock genes and nuclear receptors expression in hypothalamus and liver and circulating glucose were studied. Clock genes displayed daily rhythms in both tissues of goldfish if the light-dark cycle was present, with shifted-acrophases of negative and positive elements, as expected for proper functioning clocks. In darkness-maintained fish hypothalamic clock genes were fully arrhythmic while the hepatic ones were still rhythmic. Among studied nuclear receptors, in the hypothalamus only nr1d1 was rhythmic and only when the light-dark cycle was present. In the liver all nuclear receptors were rhythmic when both zeitgebers were present, but only nr1d1 when one of them was removed. Plasma glucose levels showed significant rhythms in fish maintained under random fed regimen or constant darkness, with the highest levels at 1-h postprandially in all groups. Altogether these results support that hypothalamus is mainly a light-entrained-oscillator, while the liver is a food-entrained-oscillator. Moreover, nuclear receptors are revealed as clear outputs of the circadian system acting as key elements in the timekeeping of temporal homeostasis, particularly in the liver.
How Did People Cope During the COVID-19 Pandemic? A Structural Topic Modelling Analysis of Free-Text Data From 11,000 United Kingdom Adults
Authors: Wright Liam , Fluharty Meg , Steptoe Andrew , Fancourt Daisy 
Published: June 2022

BackgroundThe COVID-19 pandemic has had substantial impacts on lives across the globe. Job losses have been widespread, and individuals have experienced significant restrictions on their usual activities, including extended isolation from family and friends. While studies suggest population mental health worsened from before the pandemic, not all individuals appear to have experienced poorer mental health. This raises the question of how people managed to cope during the pandemic.MethodsTo understand the coping strategies individuals employed during the COVID-19 pandemic, we used structural topic modelling, a text mining technique, to extract themes from free-text data on coping from over 11,000 UK adults, collected between 14 October and 26 November 2020.ResultsWe identified 16 topics. The most discussed coping strategy was ‘thinking positively’ and involved themes of gratefulness and positivity. Other strategies included engaging in activities and hobbies (such as doing DIY, exercising, walking and spending time in nature), keeping routines, and focusing on one day at a time. Some participants reported more avoidant coping strategies, such as drinking alcohol and binge eating. Coping strategies varied by respondent characteristics including age, personality traits and sociodemographic characteristics and some coping strategies, such as engaging in creative activities, were associated with more positive lockdown experiences.ConclusionA variety of coping strategies were employed by individuals during the COVID-19 pandemic. The coping strategy an individual adopted was related to their overall lockdown experiences. This may be useful for helping individuals prepare for future lockdowns or other events resulting in self-isolation.
Prevalence, Influencing Factors, and Clinical Characteristics of Cognitive Impairment in Elderly Patients With Schizophrenia
Authors: Liu Guojun , Zhang Xiaoying , Huo Xiaoning , Li Wei 
Published: June 2022

AimsThe purpose of this study was to investigate the prevalence, influencing factors, and clinical characteristics of cognitive impairment in elderly patients with chronic schizophrenia.Materials and MethodsA total of 264 elderly patients with chronic schizophrenia and 156 normal controls were enrolled in the current study. The Mini-mental State Examination (MMSE) was used to assess their overall cognitive function, the Positive And Negative Syndrome Scale (PANSS) was used to assess their psychotic symptoms, the Geriatric Depression Scale (GDS) was used to assess their depressive symptoms, while Activity of Daily Living Scale (ADL) was used to assess their daily living ability.ResultsThe prevalence of cognitive impairment was 77.7% (205/264) in elderly patients with chronic schizophrenia, which was much higher than that [16.7% (26/156)] in normal controls. By using stepwise binary regression analysis, we found that hobbies (p &lt; 0.001, OR = 0.224, 95% CI: 0.114–0.441) might be a protective factor for cognitive impairment, and this relationship remained statistically significant after adjusting for total scores of GDS, ADL and PANSS (modelb) (p = 0.016, OR = 0.406, 95% CI: 0.195–0.847). Compared with individuals without cognitive impairment, individuals with cognitive impairment tend to have more depression and psychiatric symptoms as well as worse activities of daily living (p &lt; 0.05). Through linear regression analysis of the mediating model, we found that hobbies may improve cognitive function by improving psychiatric symptoms, and play a partial mediating role (B = −4.789, p &lt; 0.001).ConclusionCognitive impairment is a very prominent problem in elderly patients with chronic schizophrenia. Elderly schizophrenia patients with cognitive impairment tended to have more depressive mood, more psychotic symptoms and worse activities of daily living. Hobbies will help prevent cognitive impairment in elderly patients with schizophrenia and may improve their cognitive function by influencing psychiatric symptoms. Therefore, we should encourage elderly patients with chronic schizophrenia to develop their own hobbies. However, the above conclusion still need to be further verified, as we cannot exclude the effects of age and education.
Comparative Safety Signal Assessment of Hospitalization Associated With the Use of Atypical Antipsychotics
Authors: Yunusa Ismaeel , Teng Chengwen , Karaye Ibraheem M. , Crounse Emily , Alsahali Saud , Maleki Nasim 
Published: June 2022

BackgroundPersons with symptoms of psychosis receiving treatment with atypical antipsychotics (AAPs) can experience serious adverse events (AEs) requiring admission to the hospital. The comparative likelihood of AE-related hospitalization following the use of all AAPs has not been fully characterized. Therefore, we evaluated the safety signals of hospitalizations associated with the use of AAPs.MethodsWe conducted a cross-sectional analysis using the FDA Adverse Event Reporting System (FAERS) database (from January 1, 2004, to December 31, 2021) to examine disproportionality in reporting hospitalizations suspected to be associated with 12 AAPs (aripiprazole, asenapine, brexpiprazole, clozapine, iloperidone, lurasidone, olanzapine, paliperidone, and pimavanserin, quetiapine, risperidone, and ziprasidone). Hospitalization in the FAERs database is an outcome that is recorded as a result of an AE occurring at any drug dose. We estimated reporting odds ratios (RORs) by comparing the odds of hospitalization occurring with a particular AAP to the odds of its occurrence with other drugs. In addition, we considered the presence of a significant safety signal when the lower limit of the 95% confidence interval (CI) of the ROR is &gt;1.ResultsA total of 204,287 cases of hospitalizations were reported to the FDA for individuals treated with AAPs. There were significant safety signals of hospitalization associated with using clozapine (ROR, 2.88; 95% CI, 2.84–2.92), olanzapine (ROR, 2.61; 95% CI, 2.57–2.64), quetiapine (ROR, 1.87; 95% CI, 1.85–1.89), risperidone (ROR, 1.41; 95% CI, 1.39–1.43), aripiprazole (ROR, 1.34; 95% CI, 1.32–1.35), and ziprasidone (ROR, 1.14; 95% CI, 1.10–1.18). However, no hospitalization-related safety signals were observed with the use of paliperidone, pimavanserin, iloperidone, asenapine, lurasidone, and brexpiprazole. The ROR estimates were numerically higher among older adults than younger adults.ConclusionsThis cross-sectional assessment of data from FAERs (2004–2021) suggested that users of clozapine, olanzapine, quetiapine, risperidone, aripiprazole, and ziprasidone were more likely to report being hospitalized than users of other AAPs. Given that the FAERs database only contains spontaneous reports of AEs experienced by persons exposed to a drug but without information on exposed persons who did not have an event, a cohort study comparing hospitalizations among new users of individual AAPs against each other is needed to delineate these safety signals further.
Wide-range tunable Ba0.7Sr0.3TiO3 films capacitors on LiNbO3 substrates
Authors: Mao Fei-Long , Lu Zeng-Tian , Luo Zhi-Tao , Wang Wei-Biao , Zhang Hui 
Published: June 2022

Abstract
Ba0.7Sr0.3TiO3 (BST) films on Y-cut LiNbO3 substrates are investigated to realize wide-range tunable BST capacitors. The performances of the BST films are improved by the optimal magnetron sputtering conditions. It is found that the permittivity tunability of the BST capacitor reaches 300% under an applied voltage of 5 V. Moreover, the film has a high dielectric constant 2700 under an applied voltage of 0 V, and the Q value of the BST capacitor exceeds 3000. The results demonstrate that the BST film on the LiNbO3 substrate has potential as a wide-range tunable capacitor for tunable surface acoustic wave filters.
PENGARUH EKSTRAK DAUN KATUK TERHADAP KECUKUPAN PRODUKSI ASI PADA IBU POSTPARTUM
Authors: Yolanda Puput , Indah Purnama Eka Sari Wenny , Kurniyati Kurniyati 
Published: June 2022

Pemberian ASI Ekslusif menjadi salah satu strategi global untuk meningkatkan pertumbuhan, perkembangan, kesehatan, dan kelangsungan hidup bayi. Salah satu upaya memperbanyak ASI dengan meningkatkan kualitas makanan yang berpengaruh secara langsung pada produksi air susu yaitu daun katuk. Jenis penelitian yang digunakan adalah Quasi experiment dengan rancangan two group posttest only design. Subjek penelitian adalah ibu postpartum yang memiliki bayi usia 6 bulan berjumlah 34 responden dengan teknik pengambilan sampel purposive Sampling. Uji statistik yang digunakan adalah uji paired t Test. Hasil Penelitian ini menunjukkan terdapat pengaruh pengaruh ekstrak daun katuk terhadap Kecukupan Produksi ASI pada ibu postpartum dengan hasil p-value 0,000. Ekstrak daun katuk dapat direkomendasikan sebagai alternatif bagi ibu postpartum untuk meningkatkan produksi ASI sehingga dapat meningkatkan cakupan ASI Ekslusif.
Wireless Material Identification in the Recycling Chain Using Chipless RFID Tags
Authors: Villa-Gonzalez Fatima , Bhattacharyya Rahul , Tellbach Denise , Sarma Sanjay , Li Heyi 
Published: June 2022

<p>Abstract—The utility of chipless RFID technology for the identification of 8 materials (7 plastic types and glass) in the recycling chain is examined. We first demonstrate how the frequency response of 8 Circular Ring Resonators (CRR), designed to operate in the 1.5 - 6 GHz band, are used to encode 8 unique material IDs. Tagged items are then inserted one a time in front of a chipless RFID reader and speed and accuracy of material identification is determined. We demonstrate the ability to correctly identify material type with over 90% accuracy while being 3-16X faster than other methods reported in the literature. Techniques to further improve detection speed at the cost of accuracy are then presented. Finally, future directions of exploration are also discussed.</p>
Mechanical High-Intensity Focused Ultrasound (Histotripsy) in Dogs with Spontaneously Occurring Soft Tissue Sarcomas
Authors: Arnold Lauren , Yang Ester , Gannon Jessica , Sheppard Hannah , Coutermarsh-Ott Sheryl , Ziemlewicz Timothy , Dervisis Nikolaos , Allen Irving , Daniel Gregory , Tuohy Joanne , Vlaisavljevich Eli , Klahn Shawna 
Published: June 2022

<p> Histotripsy is a non-invasive focused ultrasound therapy that uses controlled acoustic cavitation to mechanically disintegrate tissue. To date, there are no reports investigating histotripsy for the treatment of soft tissue sarcoma (STS). This study aimed to investigate the <em>in vivo </em>feasibility of ablating STS with histotripsy and to characterize the impact of partial histotripsy ablation on the acute immunologic response in canine patients with spontaneous STS. A custom 500 kHz histotripsy system was used to treat ten dogs with naturally occurring STS. Four to six days after histotripsy, tumors were surgically resected. Safety was determined by monitoring vital signs during treatment and post-treatment physical examinations, routine lab work, and owners’ reports. Ablation was characterized using radiologic and histopathologic analyses. Systemic immunological impact was evaluated by measuring changes in cytokine concentrations, and tumor microenvironment changes were evaluated by characterizing changes in infiltration with tumor-associated macrophages (TAMs) and tumor-infiltrating lymphocytes (TILs) using multiplex immunohistochemistry and differential gene expression. Results showed histotripsy ablation was achievable and well-tolerated in all ten dogs. Immunological results showed histotripsy induced pro-inflammatory changes in the tumor microenvironment. Overall, this study demonstrates histotripsy’s potential as a precise, non-invasive treatment for STS.</p>
Digital Marketing Pengaruh Digital Marketing Dan Pilihan Produk Dalam Pengambilan Keputusan Minat Membeli Konsumen Pada Marketplace Tokopedia
Authors: Suryopratomo Anggit , Jaelani Evan 
Published: June 2022

Penelitian ini dilakukan untuk mengetahui besarnya pengaruh digital marketing yang terdiri dari media social, website, PPC advertising, dan SEO Search engine optimization terhadap minat membeli konsumen dan pilihan produk pada marketplace Tokopedia. Ruang lingkup penelitian hanya membahas pengaruh digital marketing dan pilihan produk terhadap minat membeli konsumen pada marketplace Tokopedia.
Rancangan penelitian ini menggunakan jenis penelitian penjelasan (explanatory research) dengan pendekatan kuantitatif. Variabel yang digunakan dalam penelitian ini ada tiga, yaitu digital marketing ( ), Pilihan Produk ( ), dan Minat Membeli (Y). Pengumpulan data diperoleh melalui penyebaran kuesioner, populasi penelitian adalah konsumen Marketplace Tokopedia, di mana jumlah populasinya tidak diketahui.
Sampel diambil dengan teknik accidental sampling. Hasil penelitian menunjukkan bahwa: (1) ada pengaruh positif digital marketing terhadap keputusan minat membeli produk di Tokopedia; (2) tidak ada pengaruh pilihan produk terhadap keputusan minat membeli di Tokopedia; dan (3) ada pengaruh digital marketing dan pilihan produk terhadap keputusan pembelian di Tokopedia. Faktor digital marketing dan pilihan produk mempunyai pengaruh sebesar 27% terhadap keputusan minat membeli produk di Tokopedia, sedangkan sisanya 73% dipengaruhi oleh variabel lain yang tidak dimasukkan dalam penelitian ini.