bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint Inversion of GNSS and GRACE for Terrestrial Water Storage Change in California
Authors: Carlson G. , Werth S. , Shirzaei M. 
Published: March 2022

AbstractGlobal Navigation Satellite System (GNSS) vertical displacements measuring the elastic response of Earth's crust to changes in hydrologic mass have been used to produce terrestrial water storage change (∆TWS) estimates for studying both annual ∆TWS as well as multi‐year trends. However, these estimates require a high observation station density and minimal contamination by nonhydrologic deformation sources. The Gravity Recovery and Climate Experiment (GRACE) is another satellite‐based measurement system that can be used to measure regional TWS fluctuations. The satellites provide highly accurate ∆TWS estimates with global coverage but have a low spatial resolution of ∼400 km. Here, we put forward the mathematical framework for a joint inversion of GNSS vertical displacement time series with GRACE ∆TWS to produce more accurate spatiotemporal maps of ∆TWS, accounting for the observation errors, data gaps, and nonhydrologic signals. We aim to utilize the regional sensitivity to ∆TWS provided by GRACE mascon solutions with higher spatial resolution provided by GNSS observations. Our approach utilizes a continuous wavelet transform to decompose signals into their building blocks and separately invert for long‐term and short‐term mass variations. This allows us to preserve trends, annual, interannual, and multi‐year changes in TWS that were previously challenging to capture by satellite‐based measurement systems or hydrological models, alone. We focus our study in California, USA, which has a dense GNSS network and where recurrent, intense droughts put pressure on freshwater supplies. We highlight the advantages of our joint inversion results for a tectonically active study region by comparing them against inversion results that use only GNSS vertical deformation as well as with maps of ∆TWS from hydrological models and other GRACE solutions. We find that our joint inversion framework results in a solution that is regionally consistent with the GRACE ∆TWS solutions at different temporal scales but has an increased spatial resolution that allows us to differentiate between regions of high and low mass change better than using GRACE alone.
Mechanisms of Submarine Debris Flow Growth
Authors: Du Jianting , Choi Clarence Edward , Yu Jiantao , Thakur Vikas 
Published: March 2022

AbstractSubmarine debris flows are among the largest types of landslide on planet Earth. They occur under the cloak of the sea so little is known about how they reach such large volumes. Field evidence suggests that the entrainment from the sediment‐rich sea floor enables the growth of submarine debris flows. However, there is a dearth of understanding of the dynamic processes of entrainment. In this study, a new entrainment model is proposed for submarine debris flows with different clay contents. The entrainment model considers the relative contributions from basal grain friction and fluid viscous stresses that drive the entrainment process, and the effects of hydroplaning. To evaluate the new model, a new experimental setup is developed to simulate submarine debris flows, with clay contents from 4% to 12%, overriding and entraining a loose sand bed. The clay content is found to have profound effects on the entrainment dynamics. Flows with high clay contents (i.e., ≥10%) hydroplane, which enhances the mobility of the flow but reduces its entrainment potential. The predicted entrainment depths from the proposed model are consistent with the measured ones from the experiments. The proposed theoretical model and unique experimental evidence can be used as guiding tools to progress toward the inclusion of entrainment in vulnerability assessments of offshore infrastructure.
Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation
Authors: Wu Linhui , Yu Ke , Chen Kai , Zhu Xuelian , Yang Zheng , Wang Qi , Gao Junjie , Wang Yingying , Cao Tong , Xu Hui , Pan Xueshan , Wang Lixia , Xia Jun , Li Yuyun , Wang Zhiwei Peter , Ma Jia 
Published: March 2022

AbstractFbxo45, a conserved F-box protein, comprises of an atypical SKP1, CUL1, F-box protein (SCF) ubiquitin ligase complex that promotes tumorigenesis and development. However, the biological function and molecular mechanisms of Fbxo45 involved in pancreatic carcinogenesis are ambiguous. We conducted several approaches, including transfection, coIP, real-time polymerase chain reaction (RT-PCR), Western blotting, ubiquitin assays, and animal studies, to explore the role of Fbxo45 in pancreatic cancer. Here, we report that USP49 stability is governed by Fbxo45-mediated ubiquitination and is enhanced by the absence of Fbxo45. Moreover, Fbxo45 binds to a short consensus sequence of USP49 through its SPRY domain. Furthermore, Fbxo45-mediated USP49 ubiquitination and degradation are enhanced by NEK6 kinase. Functionally, Fbxo45 increases cell viability and motility capacity by targeting USP49 in pancreatic cancer cells. Xenograft mouse experiments demonstrated that ectopic expression of Fbxo45 enhanced tumor growth in mice and that USP49 overexpression inhibited tumor growth in vivo. Notably, Fbxo45 expression was negatively associated with USP49 expression in pancreatic cancer tissues. Fbxo45 serves as an oncoprotein to facilitate pancreatic oncogenesis by regulating the stability of the tumor suppressor USP49 in pancreatic cancer.
Tau deposition patterns are associated with functional connectivity in primary tauopathies
Authors: Franzmeier Nicolai , Brendel Matthias , Beyer Leonie , Slemann Luna , Kovacs Gabor G. , Arzberger Thomas , Kurz Carolin , Respondek Gesine , Lukic Milica J. , Biel Davina , Rubinski Anna , Frontzkowski Lukas , Hummel Selina , Müller Andre , Finze Anika , Palleis Carla , Joseph Emanuel , Weidinger Endy , Katzdobler Sabrina , Song Mengmeng , Biechele Gloria , Kern Maike , Scheifele Maximilian , Rauchmann Boris-Stephan , Perneczky Robert , Rullman Michael , Patt Marianne , Schildan Andreas , Barthel Henryk , Sabri Osama , Rumpf Jost J. , Schroeter Matthias L. , Classen Joseph , Villemagne Victor , Seibyl John , Stephens Andrew W. , Lee Edward B. , Coughlin David G. , Giese Armin , Grossman Murray , McMillan Corey T. , Gelpi Ellen , Molina-Porcel Laura , Compta Yaroslau , van Swieten John C. , Laat Laura Donker , Troakes Claire , Al-Sarraj Safa , Robinson John L. , Xie Sharon X. , Irwin David J. , Roeber Sigrun , Herms Jochen , Simons Mikael , Bartenstein Peter , Lee Virginia M. , Trojanowski John Q. , Levin Johannes , Höglinger Günter , Ewers Michael 
Published: March 2022

AbstractTau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. Tau is assumed to spread prion-like across connected neurons, but the mechanisms of tau propagation are largely elusive in 4-repeat tauopathies, characterized not only by neuronal but also by astroglial and oligodendroglial tau accumulation. Here, we assess whether connectivity is associated with 4R-tau deposition patterns by combining resting-state fMRI connectomics with both 2nd generation 18F-PI-2620 tau-PET in 46 patients with clinically diagnosed 4-repeat tauopathies and post-mortem cell-type-specific regional tau assessments from two independent progressive supranuclear palsy patient samples (n = 97 and n = 96). We find that inter-regional connectivity is associated with higher inter-regional correlation of both tau-PET and post-mortem tau levels in 4-repeat tauopathies. In regional cell-type specific post-mortem tau assessments, this association is stronger for neuronal than for astroglial or oligodendroglial tau, suggesting that connectivity is primarily associated with neuronal tau accumulation. Using tau-PET we find further that patient-level tau patterns are associated with the connectivity of subcortical tau epicenters. Together, the current study provides combined in vivo tau-PET and histopathological evidence that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
Electrical modulation of transplanted stem cells improves functional recovery in a rodent model of stroke
Authors: Oh Byeongtaek , Santhanam Sruthi , Azadian Matine , Swaminathan Vishal , Lee Alex G. , McConnell Kelly W. , Levinson Alexa , Song Shang , Patel Jainith J. , Gardner Emily E. , George Paul M. 
Published: March 2022

AbstractStroke is a leading cause of long-term disability worldwide, intensifying the need for effective recovery therapies. Stem cells are a promising stroke therapeutic, but creating ideal conditions for treatment is essential. Here we developed a conductive polymer system for stem cell delivery and electrical modulation in animals. Using this system, electrical modulation of human stem cell transplants improve functional stroke recovery in rodents. Increased endogenous stem cell production corresponds with improved function. Transcriptome analysis identified stanniocalcin 2 (STC2) as one of the genes most significantly upregulated by electrical stimulation. Lentiviral upregulation and downregulation of STC2 in the transplanted stem cells demonstrate that this glycoprotein is an essential mediator in the functional improvements seen with electrical modulation. Moreover, intraventricular administration of recombinant STC2 post-stroke confers functional benefits. In summation, our conductive polymer system enables electrical modulation of stem cells as a potential method to improve recovery and identify important therapeutic targets.
Measuring mechanical anisotropy of the cornea with Brillouin microscopy
Authors: Eltony Amira M. , Shao Peng , Yun Seok-Hyun 
Published: March 2022

AbstractLoad-bearing tissues are typically fortified by networks of protein fibers, often with preferential orientations. This fiber structure imparts the tissues with direction-dependent mechanical properties optimized to support specific external loads. To accurately model and predict tissues’ mechanical response, it is essential to characterize the anisotropy on a microstructural scale. Previously, it has been difficult to measure the mechanical properties of intact tissues noninvasively. Here, we use Brillouin optical microscopy to visualize and quantify the anisotropic mechanical properties of corneal tissues at different length scales. We derive the stiffness tensor for a lamellar network of collagen fibrils and use angle-resolved Brillouin measurements to determine the longitudinal stiffness coefficients (longitudinal moduli) describing the ex vivo porcine cornea as a transverse isotropic material. Lastly, we observe significant mechanical anisotropy of the human cornea in vivo, highlighting the potential for clinical applications of off-axis Brillouin microscopy.
Neural oscillations during motor imagery of complex gait: an HdEEG study
Authors: Putzolu Martina , Samogin Jessica , Cosentino Carola , Mezzarobba Susanna , Bonassi Gaia , Lagravinese Giovanna , Vato Alessandro , Mantini Dante , Avanzino Laura , Pelosin Elisa 
Published: March 2022

AbstractThe aim of this study was to investigate differences between usual and complex gait motor imagery (MI) task in healthy subjects using high-density electroencephalography (hdEEG) with a MI protocol. We characterized the spatial distribution of α- and β-bands oscillations extracted from hdEEG signals recorded during MI of usual walking (UW) and walking by avoiding an obstacle (Dual-Task, DT). We applied a source localization algorithm to brain regions selected from a large cortical-subcortical network, and then we analyzed α and β bands Event-Related Desynchronizations (ERDs). Nineteen healthy subjects visually imagined walking on a path with (DT) and without (UW) obstacles. Results showed in both gait MI tasks, α- and β-band ERDs in a large cortical-subcortical network encompassing mostly frontal and parietal regions. In most of the regions, we found α- and β-band ERDs in the DT compared with the UW condition. Finally, in the β band, significant correlations emerged between ERDs and scores in imagery ability tests. Overall we detected MI gait-related α- and β-band oscillations in cortical and subcortical areas and significant differences between UW and DT MI conditions. A better understanding of gait neural correlates may lead to a better knowledge of pathophysiology of gait disturbances in neurological diseases.
Function of SYDE C2-RhoGAP family as signaling hubs for neuronal development deduced by computational analysis
Authors: Kouchi Zen , Kojima Masaki 
Published: March 2022

AbstractRecent investigations of neurological developmental disorders have revealed the Rho-family modulators such as Syde and its interactors as the candidate genes. Although the mammalian Syde proteins are reported to possess GTPase-accelerating activity for RhoA-family proteins, diverse species-specific substrate selectivities and binding partners have been described, presumably based on their evolutionary variance in the molecular organization. A comprehensive in silico analysis of Syde family proteins was performed to elucidate their molecular functions and neurodevelopmental networks. Predicted structural modeling of the RhoGAP domain may account for the molecular constraints to substrate specificity among Rho-family proteins. Deducing conserved binding motifs can extend the Syde interaction network and highlight diverse but Syde isoform-specific signaling pathways in neuronal homeostasis, differentiation, and synaptic plasticity from novel aspects of post-translational modification and proteolysis.
A straightforward edge centrality concept derived from generalizing degree and strength
Authors: Bröhl Timo , Lehnertz Klaus 
Published: March 2022

AbstractVertex degree—the number of edges that are incident to a vertex—is a fundamental concept in network theory. It is the historically first and conceptually simplest centrality concept to rate the importance of a vertex for a network’s structure and dynamics. Unlike many other centrality concepts, for which joint metrics have been proposed for both vertices and edges, by now there is no concept for an edge centrality analogous to vertex degree. Here, we propose such a concept—termed nearest-neighbor edge centrality—and demonstrate its suitability for a non-redundant identification of central edges in paradigmatic network models as well as in real-world networks from various scientific domains.
Monitoring fluid intake by commercially available smart water bottles
Authors: Cohen Rachel , Fernie Geoff , Roshan Fekr Atena 
Published: March 2022

AbstractFluid intake is important to prevent dehydration and reduce recurrent kidney stones. There has been a trend in recent years to develop tools to monitor fluid intake using “smart” products such as smart bottles. Several commercial smart bottles are available, mainly targeting health-conscious adults. To the best of our knowledge, these bottles have not been validated in the literature. This study compares four commercially available smart bottles in terms of both performance and functionality. These bottles are the H2OPal, HidrateSpark Steel, HidrateSpark 3, and Thermos Smart Lid. One hundred intake events for each bottle were recorded and analyzed versus ground truth obtained from a high-resolution weight scale. The H2OPal had the lowest Mean Percent Error (MPE) and was able to balance out errors throughout multiple sips. The HidrateSpark 3 provided the most consistent and reliable results, with the lowest per sip error. The MPE values for HidrateSpark bottles were further improved using linear regression, as they had more consistent individual error values. The Thermos Smart Lid provides the lowest accuracy, as the sensors do not extend through the entire bottle, leading to many missed recordings.
Z-folding aircraft electromagnetic scattering analysis based on hybrid grid matrix transformation
Authors: Zhou Zeyang , Huang Jun 
Published: March 2022

AbstractTo study the electromagnetic scattering characteristics of a morphing aircraft with Z-folding wings, a method of hybrid grid matrix transformation (HGMT) is presented. The radar cross-section (RCS) of the aircraft in the four Z-folding modes is calculated and analyzed. When considering the deflection of the outer wing separately, the RCS of the wing under the head and side azimuth shows obvious dynamic characteristics, while the peak and fluctuation range are quite different. When the mid wing and the outer wing are deflected upwards together, the RCS of the aircraft under the positive side direction could be significantly reduced. When the mid wing deflects upward and the outer wing remains level, the peak of the side RCS of the aircraft is slightly reduced. When the mid wing deflects upwards and the outer wing deflects downwards, this peak indicator is further reduced, while the local fluctuation of the side RCS of the aircraft is increased. The HGMT method is effective to study the electromagnetic scattering characteristics of the Z-folding aircraft.
Belief in biological origin of race (racial essentialism) increases sensitivities to cultural category changes measured by ERP mismatch negativity (MMN)
Authors: Zeng Ginger Qinghong , Xiao Xue-Zhen , Wang Yang , Tse Chun-Yu 
Published: March 2022

AbstractThe dynamic multicultural view explains culture-specific effects on cognition that cultural knowledge is organized in multiple knowledge systems which are specific to each culture and differentially activated when exposed to related objects or scenes. This view predicts automatic categorizations of environmental information according to the culture-specific knowledge systems. This study investigated whether cultural information could be spontaneously categorized, and the modulation of this process by the belief in the biological origin of race (i.e., racial essentialism) with an event-related brain potential, the visual Mismatch Negativity (vMMN). Deviant pictures of Eastern (Western) culture were randomly presented in a stream of standard Western (Eastern) pictures while participants were playing a video game. Participants who endorse racial essentialism (high group) showed vMMNs to the deviants with high relevance to the Eastern or Western culture and the deviant with low Eastern relevance; while participants with low racial essentialism showed vMMN to the deviant with high Eastern relevance only. These results revealed spontaneous cultural categorization with vMMN and the top-down modulation of spontaneous categorization by personal belief. In addition, this is the first demonstration of MMNs to cultural deviance and the potentials in applying MMNs to study psychological essentialism and social categorization.
An Aotearoa New Zealand survey of the impact and diagnostic delay for endometriosis and chronic pelvic pain
Authors: Tewhaiti-Smith Jordan , Semprini Alex , Bush Deborah , Anderson Augustus , Eathorne Allie , Johnson Neil , Girling Jane , East Michael , Marriott Joy , Armour Mike 
Published: March 2022

AbstractChronic pelvic pain (CPP) causes important negative effects on quality of life. Endometriosis is the most common cause of CPP in females, and diagnostic delay is over six years internationally. Data remain scarce for CPP impact or diagnostic delay in Aotearoa New Zealand. This study used an online survey to explore the impact of CPP on various life domains for those aged over 18. Additionally, for those with an endometriosis diagnosis, diagnostic delay and factors affecting this over time were explored. There were 800 respondent (620 with self-reported endometriosis). CPP symptoms, irrespective of final diagnosis, started prior to age 20 and negatively impacted multiple life domains including employment, education, and relationships. Mean diagnostic delay for those with endometriosis was 8.7 years, including 2.9 years between symptom onset and first presentation and 5.8 years between first presentation and diagnosis. Five doctors on average were seen prior to diagnosis. However, there was a reduction in the interval between first presentation and diagnosis over time, from 8.4 years for those presenting before 2005, to two years for those presenting after 2012. While diagnostic delay is decreasing, CPP, irrespective of aetiology, continues to have a significant negative impact on the lives of those affected.
Evaluation of vascular endothelial growth factor (VEGF) level in the tears and serum of age-related macular degeneration patients
Authors: Shahidatul-Adha Mohamad , Zunaina Embong , Aini-Amalina Mazlan N. 
Published: March 2022

AbstractAge-related macular degeneration (AMD) is an important cause of irreversible central blindness worldwide. Clinical manifestations range from asymptomatic in early and intermediate AMD to significant vision loss in late AMD. Approximately 10% of cases of early AMD eventually progress to the late advanced stage, influenced by the upregulation of vascular endothelial growth factor (VEGF). In this study, we evaluated VEGF concentration in the tears and serum of AMD patients. Our study revealed a significantly higher level of VEGF in the tears of patients with AMD compared with controls. The tear VEGF level has high sensitivity and specificity, and is significantly related to the severity of AMD, whilst serum VEGF level is non-specific and non-predictive of AMD severity. Thus, VEGF level in the tears may be used as a non-invasive biomarker for AMD progression. A large cohort study is needed for further verification.
The role of the Pacific Decadal Oscillation and ocean-atmosphere interactions in driving US temperature predictability
Authors: Vijverberg Sem , Coumou Dim 
Published: March 2022

AbstractHeatwaves can have devastating impact on society and reliable early warnings at several weeks lead time are needed. Previous studies showed that north-Pacific sea surface temperatures (SST) can provide long-lead predictability for eastern US temperature, mediated by an atmospheric Rossby wave. The exact mechanisms, however, are not well understood. Here we analyze two different Rossby waves associated with temperature variability in western and eastern US, respectively. Causal discovery analyses reveal that both waves are characterized by positive ocean-atmosphere feedbacks at daily timescales. Only for the eastern US, a long-lead causal link from SSTs to the Rossby wave exists, which generates summer temperature predictability. We show that this SST forcing mechanism originates from the evolution of the winter-to-spring Pacific Decadal Oscillation (PDO). During pronounced winter-to-spring PDO phases (either positive or negative) eastern US summer temperature forecast skill more than doubles, providing a temporary window of enhanced long-lead predictability.
Synthesis of aryl cobalt and iron complexes and their catalytic activity on hydrosilylation of alkenes
Authors: Huang Wei , Lu Jiahui , Fan Qingqing , Li Xiaoyan , Hinz Alexander , Sun Hongjian 
Published: March 2022

Four aryl Co and Fe complexes, (F4C5N)CoCl(PMe3)3 (1), (F4C5N)Fe(PMe3)4 (2), (F5C6)CoCl(PMe3)3 (3) and (F4C5)FeCl(PMe3)3(4), were synthesized from the reactions of 3-chloro-2,4,5,6-tetrafluoro-pyridine and chloropentafluorobenzene with Co(PMe3)4and Fe(PMe3)4, respectively.