bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Review Article on Proniosome: As A Drug Carrier
Authors: Sachan Anupam Kr. , Kumar Sunil , Dwivedi Tapasya 
Published: March 2022

A drug carrier is any substrate used in the process of drug delivery.
The basic component of the drug delivery system is an appropriate drug carrier that sets out to improve the selectivity, effectiveness, and safety of drug administration. So, based on their biocompatible, biodegradable, and non-immunogenic structure, Proniosomes are promising drug carriers that are non-ionic surfactant-based multilamellar or unilamellar vesicle are now widely used as an alternative to the liposome. On the basis of structure, they are similar to liposomes in having bilayer but having chemical differences in monomer units which make Proniosomes stable. They can entrap both hydrophilic and lipophilic drugs of using either in an aqueous layer or in the vesicular membrane. Proniosomal carriers are suitable for the transdermal delivery of numerous pharmacological agents, including antioxidant, anticancer, anti-inflammatory, antimicrobial, and antibacterial molecules.
MENGEMBANGKAN KREATIVITAS SENI ANAK MELALUI ME-DIA LOOSE PARTS DALAM PEMBELAJARAN DARING
Authors: Laelasari Eva , Windarsih Chandra Asri , Alam Syah Khalif 
Published: March 2022

This research is motivated by the lack of creativity of early childhood art in imagining, issuing ideas, and exploring through the media. Therefore, it takes a game that can stimulate these abilities. The purpose of the research is to describe loose parts of media in developing children's artistic creativity in online learning, the 2020/2021 school year. This study uses a qualitative descriptive method with the research subjects of children aged 5-6 years who numbered 14 children of group B in KB Al-Jihad. Research data collection techniques are documentation, observation, and interviews. Data analysis in the form of data reduction activities, data display, and conclusion drawing. The results of this study showed that after doing activities using loose parts media, children's artistic creativity skills can develop according to the stage of development, using simple media such as natural materials, plastic materials, metal, wood and bamboo, glass and Kramnik, and packaging containers, which are implemented according to the theme of learning. In addition, it was found that using loose parts can develop the creativity of children's art characterized by children being able to think creatively and innovatively, and can foster new relationships with the environment.Penelitian ini dilatar belakangi kurangnya kemampuan kreativitas seni anak usia dini dalam berimajinasi, mengeluarkan ide, serta berkesplorasi melalui media. Dengan sebab itu, dibutuhkan sebuah permainan yang dapat menstimulus kemampuan tersebut. Tujuan penelitian ini untuk mendeskripsikan media loose partsdalam mengembangkan kreativitas seni anak pada pembelajaran daring, tahun pelajaran 2020/2021. Penelitian ini menggunakan metode deskriptif kualitatif dengan subjek penelitian anak usia 5-6 tahun yang berjumlah 14 anak kelompok B di KB Al-Jihad. Teknik pengumpulan data peneliti yaitu dokumentasi, observasi, dan wawancara. Analisis datanya berupa aktivitas reduksi data, display data dan penarikan kesimpulan. Hasil penelitian ini menunjukan bahwa setelah melakukan kegiatan menggunakan media loose partskemampuan kreativitas seni anak dapat berkembang sesuai tahap perkembangannya, dengan menggunakan media sederhana seperti bahan alam, bahan plastik,logam, kayu dan bambu, kaca dan kramik, dan bekas kemasan, yang di implementasikan sesuai tema pembelajaran. Selain itu, ditemukan bahwa dengan menggunakan loose partsdapat mengembangkan kreativitas seni anak ditandai dengan anak mampu berpikir kreatif dan inovatif, serta dapat menumbuhkan hubungan baru dengan alam sekitar.
Effects of Intensive Lifestyle Intervention on All-Cause Mortality in Older Adults With Type 2 Diabetes and Overweight/Obesity: Results From the Look AHEAD Study
Authors:   Look AHEAD Research Group, Wing Rena R. , Bray George A. , Cassidy-Begay Maria , Clark Jeanne M. , Coday Mace , Egan Caitlin , Evans Mary , Foreyt John P. , Glasser Stephen , Gregg Edward W. , Hazuda Helen P. , Hill James O. , Horton Edward S. , Isaac Juan Carlos , Jakicic John M. , Jeffery Robert W. , Johnson Karen C. , Kahn Steven E. , Kritchevsky Stephen , Lewis E. , Maruthur Nisa M. , J. Maschak-Carey Barbara , Nathan David M. , Patricio Jennifer , Peters Anne , Pi-Sunyer Xavier , Reboussin David , Ryan Donna H. , Ruelas Valerie , Steinburg Helmut , Toledo Katie , Wadden Thomas A. , Wagenknecht Lynne E. , Wesche-Thobaben Jacqueline , Wyatt Holly , Yanovski Susan Z. , Zhang Ping 
Published: March 2022

OBJECTIVE
Look AHEAD, a randomized trial comparing intensive lifestyle intervention (ILI) and diabetes support and education (DSE) (control) in 5,145 individuals with overweight/obesity and type 2 diabetes, found no significant differences in all-cause or cardiovascular mortality or morbidity during 9.6 (median) years of intervention. Participants in ILI who lost ≥10% at 1 year had lower risk of composite cardiovascular outcomes relative to DSE. Since effects of ILI may take many years to emerge, we conducted intent-to-treat analyses comparing mortality in ILI over 16.7 years (9.6 years of intervention and then observation) to DSE. In a secondary exploratory analysis, we compared mortality by magnitude of weight loss in ILI relative to DSE.

RESEARCH DESIGN AND METHODS
Primary outcome was all-cause mortality from randomization to 16.7 years. Other outcomes included cause-specific mortality, interactions by subgroups (age, sex, race/ethnicity, and cardiovascular disease history), and an exploratory analysis by magnitude of weight loss in ILI versus DSE as reference. Analyses used proportional hazards regression and likelihood ratio.

RESULTS
The incidence of all-cause mortality did not differ significantly in ILI and DSE (549 and 589 participants, respectively) (hazard ratio [HR] 0.91 [95% CI 0.81, 1.02]; P = 0.11). There were no significant differences between treatments in cause-specific mortality or within prespecified subgroups. ILI participants who lost ≥10% at 1 year had a 21% reduced risk of mortality (HR 0.79 [95% CI 0.67, 0.94]; P = 0.007) relative to DSE.

CONCLUSIONS
ILI focused on weight loss did not significantly affect mortality risk. However, ILI participants who lost ≥10% had reduced mortality relative to DSE.
Intertextual Inclusions in Russian Spiritual Epistolary Communication: Typology, Functions, Context
Authors: Smolina A. N. 
Published: March 2022

Intertextual inclusions (quotations, reminiscences, allusions) functioning in Russian spiritual epistolary communication are considered. Their types are presented: biblical (Old Testament and New Testament), patristic, prayer, hymnographic (from psalms and akathists), hagiographic. Their main functions are indicated: meaning-forming, argumentative, prescriptive, evaluative, syndicative, aesthetic. Based on the material of the letters of Russian church writers of the 20th century, the features of the use of intertextual inclusions from Christian texts that have become part of the spiritual heritage are shown in the church-religious style. The following features were revealed: (1) formation of meanings with the help of quotations, reminiscences and allusions, connected with the spiritual education of the addressee, his moral perfection, the creation of an inner man in himself, strengthening in faith, the study of the foundations of Christianity, the knowledge of church Orthodox life; (2) focus on Christian values: the gospel commandments, the doctrine of salvation, Christian virtues, and others; (3) prescribing perfection in acquiring mercy, humility, patience, obedience, sobriety, non-possession, repentance and other virtues, fighting sins, reading the Gospel and the writings of the holy fathers; an expression of evaluation of sweat in relation to sins and virtues, issues related to spiritual education and development, the fulfillment of church rules and Christian commandments, the achievement of soul salvation, following the instructions of confessors; (4) creation and strengthening of a common spiritual and religious space through the implementation of the iconic function of intertextual inclusions.
Influence of Biodiesel on Performance of Machine-Tractor Units
Authors: Nadykto Volodymyr , Findura Pavol , Kyurchev Volodymyr , Orel Oleksander 
Published: March 2022

Abstract
Currently, liquid biofuels, and especially biodiesel, are increasingly used. In terms of agricultural production, there arises an urgent question whether utilization of biofuels in agricultural tractors is feasible and efficient. Majority of results regarding the biodiesel use comes from bench tests of engines. However, work of any machine-tractor unit under real conditions, except for the steady-state mode of movement, includes acceleration mode after a turn, or after it was forced stop in the field. It has been established that the addition of sunflower methyl ester (SME) into conventional diesel (CD) leads to a decrease in the throttle response of a tractor engine during its field operation. Using 50% CD and 50% SME as fuel mixture, the tillage machine-tractor unit’s acceleration time increased by 16.6%. Operating on SME only, the unit’s acceleration time reached 50%. The acceleration process of a machine-tractor unit using fuel with addition of SME is non-linear. It consists of two parts: more intensive − with SME content in diesel fuel of up to 50%, and less intensive − with an increase in SME proportion over 50%. When using a mixture of CD with SME in a ratio of 50 : 50, the soil cultivation machine-tractor unit performance decreased by 7.2%, and fuel consumption per tilled area increased by 5.3%.
Characteristics of Distance Errors of Infrared Sensor Relation to Colour Surfaces
Authors: Hrubý Dušan , Vacho Lukáš , Kubík Ľubomír , Tóth Ladislav , Baláži Juraj , Kósa Patrik , Kišev Marián 
Published: March 2022

Abstract
This paper deals with the determination of the absolute errors of a small time of flight (ToF) distance sensor with respect to coloured surfaces at different illumination intensities. The aim was to determine the absolute error of the measured distance by the VL53L1X sensor when set to short-mode and long-mode at different illumination intensities: 10 lx and 350 lx depending on the coloured surface using regression analysis methods. The research was performed using 7 colour samples with different spectral colours determined according to the CIE Lab colour model. Based on the performed experiments, it was found that the error at different sensor settings, change of colour surface and different illumination intensity is approximated by a linear function only up to a certain measured distance. The process is influenced by proposed factors such as: illumination intensity, coloured surface with different illumination reflectance and signal-noise parameters of the tested sensor during the experiment.
The Use of University Biosystem Environmental Protection Platform to Prevent a New Outbreak of the COVID-19 Pandemic
Authors: Shcherbak Valeriia , Ganushchak-Yefimenko Liudmyla , Nifatova Olena , Kosiba Ján , Holota Tomáš , Yatsenko Valentуna 
Published: March 2022

Abstract
The purpose of this study was to determine the possibility of practical use of the Hackathon Platform for ecological protection of the university biosystem to prevent a new outbreak of the COVID-19 pandemic. The COVID-19 pandemic significantly affects companies and population’s behaviour. The most significant change occurred in the attitude of companies to the environment from technical and technological points of view. To increase their production sustainability, these companies are looking at the possibilities of waste recovery through sustainable recycling, or recovery of waste as a source of secondary raw material. One of the simplest ways is to use agricultural waste for energy purposes, bringing bioenergy to the forefront as a new area of Industry 4.0. The ALARA model was used to assess the quality of six biosystem components (atmospheric air, water resources, soil layer, the level of land pollution with chemicals and littering by the unauthorized dumps; sufficient volume of green planting on the territory). This allowed the development of management decisions and environmental protection measures based on the system of calculated indicators of potential environmental damage for each of six biosystem components. The forecast of plan implementation: the quality of four from among six biosystem components (atmospheric air, water resources, soil layer, sufficient volume of green planting on the territory) will increase on average by 30–40%. A minor improvement in the quality of the other biosystem components (approx. by 10%) raises concerns about the high probability of a new outbreak of the COVID-19 pandemic.
Diabetic nephropathy patient with heavy proteinuria: A case report
Authors: Yu Pei , Lu Manman , Liu Dongwei , Gao Dan 
Published: March 2022

Abstract
We herein report a case of advanced stage rapidly progressive diabetic nephropathy that finally received long-term renal replacement therapy. A 53-year-old man with hypertension and heavy proteinuria suffered rapid progression of DKD [estimated glomerular filtration rate (eGFR): 18 mL/min/1.73m2; proteinuria: 12.21 g/d]. Renal biopsy revealed diabetic nephropathy (Class III) with severe interstitial lesion and tubular atrophy. Despite aggressive treatment, the proteinuria and blood pressure were poorly controlled. The patient finally became dialysis dependent. We hold the position that this is related to his proteinuria and hypertension.
Yoga exercise intervention improves balance control and prevents falls in seniors aged 65+
Authors: Krejčí Milada , Hill Martin , Kajzar Jiří , Tichý Miroslav , Hošek Vaclav 
Published: March 2022

Abstract

Introduction
Body balance control represents a key factor preventing falls and subsequent injuries in seniors aged 65+. Intervention based on yoga exercises seem to be effective in improving balance.

Objective
The objective is to analyse and compare changes in static, dynamic, and total balance scores, changes in body composition and social indices as effects of yoga-based intervention.

Methods
A total of 500 participants (234 men aged 74.5 SD±7.74 and 266 women aged 76.9 SD±7.23) were assessed using the Tinetti Balance Assessment Tool, the InBody 230 bioimpedance body composition analyser, and the SF-36 Health Survey, applied to pre and post-testing. The experimental group (n=262; 122 males; 140 females) underwent a four-week yoga-based intervention, 30 minutes daily, while the control group (n=238; 112 males; 126 females) underwent its usual daily programme at senior homes or centres. The ANOVA model, consisting of the Group, Stage, Subject and Group × Stage interaction factors, was used for data evaluation.

Results
Intervention led to improvements in the static, dynamic and total balance scores in the experimental group compared to the control group. The results of SF-36 showed positive changes in the psychosocial aspects of health, such as promoting of calmness and happiness in male seniors and reducing fatigue, nervousness and depression in female seniors. The post-intervention decrease in body fat percentage and increase in muscle mass in seniors is discussed.

Conclusions
The four-week yoga-based intervention had positive effects on the static, dynamic and total balance scores, body composition and social status.
Technological competency as caring in nursing: A description, analysis and evaluation of the theory
Authors: Krel Cvetka , Vrbnjak Dominika , Bevc Sebastjan , Štiglic Gregor , Pajnkihar Majda 
Published: March 2022

Abstract

Introduction
When introducing and using technology in nursing, there is a danger that too much focus is placed on technology over caring for patients. The ‘Technological competency as caring in nursing’ theory can facilitate technology in caring, but the theory needs to be described, analysed and evaluated before it is used. The purpose of the literature review was to determine the possibility of applying the theory in education, research and practice, and whether the theory could be used to guide research into the use of electronic nursing record systems.

Methods
A literature search was conducted in PubMed, CINAHL, ScienceDirect, Google Scholar and Google Books, and supplemented with manual searching using the keywords ‘Locsin’, ‘technology’, ‘caring’ and ‘nursing theory’. The criteria for inclusion were fully accessible articles and books in English on the relevant topics. The review process is shown in a PRISMA diagram. A hierarchy of evidence was used to evaluate the relative strength of the results. Pajnkihar’s model was used to describe, analyse and evaluate the theory.

Results
A total of 26 hits were included in the final analysis. The theory in question meets the criteria of clarity, simplicity and complexity, adequacy, importance and significance; it can be tested; and it is useful in patient care that employs technology.

Discussion and conclusion
The theory is useful in nursing education, research and practice. The theory will be used to guide research on the perception of technological competency and care of internal medicine patients by nurses when using the electronic nursing record system in three Slovenian hospitals.
Pública, democrática e plural
Authors: Amorim Simone , Oliveira Taísa 
Published: March 2022

O artigo apresenta o Conselho de Representantes (CR) da Faculdade de Letras da Universidade do Porto, com o objetivo de compreender o seu papel na consolidação de um canal regular de escuta do corpo discente, que promova o exercício democrático na universidade, a partir da inclusão de um ator estratégico: o/a estudante. O CR é um dos órgãos centrais da governança da faculdade e a ele são atribuídas funções vitais ao ambiente universitário, tais como: a aprovação de plano anual de atividades, o orçamento e o aumento ou redução no valor das propinas. O artigo apresenta duas visões que, ao detalhar o referido órgão, nos permitiram discutir em que medida a universidade estimula a consolidação de um ambiente democrático e questionador que consiga extrapolar a atuação cívica do seu corpo discente para uma participação crítica na sociedade. No que concerne ao design deste estudo de caso, optou-se pelo uso de metodologias qualitativas, por meio de entrevistas semi-diretivas em profundidade, a partir da escolha aleatória de duas estudantes de Licenciatura em Sociologia, e de três representantes dos/as estudantes no CR. Procurou-se, dessa forma, compreender os desafios à consolidação de um ambiente participativo na universidade a partir dos discursos de quem vivencia a instituição de dentro de sua estrutura.

Recebido: 10/5/2021
Aceite: 15/9/2021
“Todos nós temos um bocadinho de ativismo”
Authors: Garcia Ana Dias , Macedo Eunice , Queirós João 
Published: March 2022

O presente artigo tem como objetivo trazer ao palco do debate direitos de cidadania ativista de jovens. Para isso, apresenta argumentos que desmontam pressupostos que desconsideram e desqualificam as pessoas jovens, sobretudo as menores de 18 anos, enquanto cidadãs ativas e capazes de se envolver em causas comuns, criar propostas e participar em processos de tomada de decisão. O cenário é o de uma investigação participativa com base em métodos artísticos e orientada para a ação, em que jovens entre os 14 e os 17 anos do grupo de pesquisa participaram na Greve Climática Estudantil que aconteceu no Porto em maio e setembro de 2019. Desencadeada pela jovem ativista Greta Thunberg, esta mobilização internacional de jovens pela justiça ambiental e social foi um dos palcos onde foram observadas e analisadas práticas participativas do grupo. Esta experiência evidenciou desejos de liberdade e a necessidade destas pessoas jovens se expressarem, serem vistas, ouvidas e consideradas na gestão de assuntos que as afetam direta ou indiretamente, portanto, de exercerem cidadania. Simultaneamente, revelou-se a necessidade de compreensão das limitações às estruturas de acesso e oportunidade de participação como exercício de cidadania, do reconhecimento de formas e contextos plurais de expressão e participação jovem.

Recebido: 14/5/2021
Aceite: 6/12/2021
agenda e o discurso da qualidade em educação
Authors: Braga Altamiro , Torres Leonor 
Published: March 2022

O presente artigo expõe os principais resultados da pesquisa de doutoramento em ciências da educação, especialização em sociologia da educação e políticas educativas. Ancorada numa abordagem qualitativa, a investigação se desenvolveu através do estudo de caso de duas escolas públicas brasileiras e um agrupamento de escolas em Portugal. O objetivo da pesquisa pautou-se em analisar os limites da participação democrática através da presença do discurso da qualidade em educação.
Para além da vasta análise documental, realizaram-se entrevistas e inquéritos por questionário aos/às professores/as e gestores/as das escolas tomadas como estudo de caso com o objetivo de explorar suas relações com o discurso da qualidade e as interferências nas possibilidades de participação democrática das escolas. Os resultados apontam para uma intensa influência das resoluções dos poderes públicos do Brasil e de Portugal, sob a égide do discurso da qualidade, no processo de racionalização e burocratização da vida escolar. As escolas apresentam investidas para a garantia de qualidade em educação que, com efeito, imputam à docência e à escola um ritmo industrial de trabalho, aprofundando a limitação da participação democrática nos rumos da escola, prevalecendo a escola para o trabalho de execução de tarefas e alcance de resultados de qualidade.

Recebido: 30/05/2021
Aceite: 22/11/2021
KENYAMANAN INAP AT CAPSULE HOSTEL SEBAGAI DESAIN COMPACT
Authors: Wari Ahmad Muzzayin Dina , Rahardjo Setiamurti , Widyaevan Dea Aulia 
Published: March 2022

AbstractThe increasing number of millennial travelers has affected the growth of backpacker accommodations in Bandung, especially those which are built in a form of capsules. Located at the city center of Bandung, “Inap at Capsule Hostel” has many facilities, all of which are installed inside the capsules and make the design compact. Although all of those facilities are dimensionally accommodated, the anthropometric comfort of the capsule is still questionable since there are spaces required for body movements. With combining the qualitative method through experiencing the capsule’s interior directly and the quantitative method through analyzing reviews from booking websites with the instrument word cloud text analysis, it is found that the compact design of Inap at Capsule Hostel still represents the anthropometric comfort regardless its limited dimension. Nevertheless, rearrangement of some lighting facilities and materials inside the capsules is suggested to improve the quality of the spatial comfort. AbstrakMeningkatnya wisatawan milenial menjadi salah satu faktor pendorong berkembangnya penginapan backpacker berbentuk kapsul di kota Bandung. Inap at Capsule Hostel yang terletak di pusat kota Bandung memiliki lima belas fasilitas yang semuanya terletak di dalam unit kapsulnya dan membuat desainnya padat. Meskipun seluruh fasilitas tersebut dapat tertampung secara dimensi, tapi hal ini belum tentu sejalan dengan kenyamanan kapsul ini saat digunakan karena tubuh manusia memiliki aktivitas gerak yang membutuhkan ruang tambahan. Dengan memadukan metode kualitatif melalui pengalaman ruang secara langsung dan metode kuantitatif melalui olahan data review dari situs pemesanan akomodasi dengan word cloud text analysis, ternyata ditemukan bahwa unit yang padat pada Inap at Capsule Hostel masih nyaman digunakan meski secara dimensi terhitung sempit bagi ruang gerak manusia. Meskipun demikian, disarankan adanya penataan ulang beberapa fasilitas pencahayaan serta penggunaan material untuk meningkatkan kualitas kenyamanan ruangnya.