bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined experimental and TD-DFT/DMOl3 investigations, optical properties, and photoluminescence behavior of a thiazolopyrimidine derivative
Authors: Abozeed Amina A. , Younis Osama , Al-Hossainy Ahmed F. , El-Mawla Nada Abd , Sayed Mostafa , M. Kamal El-dean Adel , Tolba Mahmoud S. 
Published: September 2022

AbstractWe present here the FT-IR, DFT computation, XRD, optical, and photophysical characterization of a heterocyclic compound with thienopyrimidine and pyran moieties. TD-DFT/DMOl3 and TD-DFT/CASTEP computations were used to study the geometry of isolated and dimer molecules and their optical behavior. The indirect (3.93 eV) and direct (3.29 eV) optical energy bandgaps, HOMO–LUMO energy gap (3.02 eV), and wavelength of maximum absorption (353 nm) were determined in the gas phase with M062X/6-31+G (d, p). A thin film of the studied molecule was studied using XRD, FT-IR, and UV–Vis spectroscopy. The average crystallite size was found as 74.95 nm. Also, the photoluminescence spectroscopy revealed that the compound exhibited different emission bands at the visible range with different intensities depending on the degree of molecular aggregation. For instance, solutions with different concentrations emitted blue, cyan, and green light. On the other hand, the solid-state material produced a dual emission with comparable intensities at λmax = 455, 505, and 621 nm to cover the entire visible range and produce white emission from a single material with CIE coordinates of (0.34, 0.32) that are very similar to the ideal pure white light. Consequently, these findings could lead to the development of more attractive new luminous materials.
Field measurement of local wind environment on the approach deck of a suspension bridge in mountain terrain
Authors: Zhang Mingjin , Jiang Fanying , Zhang Jingyu , Qin Jingxi , Jiang Xulei , Li Yongle 
Published: September 2022

AbstractThe local wind environment above the bridge deck affects the aerodynamic characteristics of vehicles, thus affecting the driving safety of the bridge deck. Influenced by the mountain topography and the bridge deck's ancillary facilities, the local wind environment above the bridge deck is complex and changeable, and its impact on the bridge deck traffic can not be ignored. In order to accurately evaluate the local wind field parameters, a monitoring system of the local wind environment is developed. Utilizing the monitoring system, wind parameters above the approach deck of a long-span suspension bridge in a mountain area are measured. The relationship of wind characteristics between the incoming flow and the wind above the bridge deck is investigated. Results show the significant difference between the local wind environment above the bridge deck and the incoming flow's characteristics; the wind profile above the bridge deck does not follow the exponential distribution; the equivalent height of the wind load on the vehicle is higher than the vehicle's gravity centre. This study is relevant for studying the local wind environment, driving safety, and serviceability of long-span bridges in mountainous areas.
A proposed synergetic mechanism for metal fume fever involving ZnO and Fe3O4 nanoparticles
Authors: Suárez Guillaume , Niculita-Hirzel Hélène , Correia Daniela , Pralong Jacques A. , Vernez David 
Published: September 2022

AbstractMetal fumes fever (MFF) is an inflammatory condition, whose mechanism is yet unclear, associated with the inhalation of metal fumes, particularly zinc. In this study we investigate experimentally the hypothesis of a two-step mechanism of MFF onset: (1) the photocatalytic production of airborne hydrogen peroxide (H2O2) via ZnO and (2) the production of hydroxyl radicals (HOׄ) through Fenton reaction via magnetite (Fe3O4) nanoparticles. Photocatalysis and Fenton reaction products were measured using a multiscattering-enhanced absorbance device and assessing the degradation of bromophenol blue with microplate photometry, respectively. We observed that in the presence of UV, ZnO produces 3 to 4-times more H2O2 than UV alone or that non-UV irradiated ZnO. In the presence of biologically-relevant ligands, we also measured a Fenton reaction at physiological pH with either Fe(II), Fe(III) or Fe3O4 nanoparticles. Our results support the hypothesis of a two-step mechanism of MFF onset, in which the prior presence of Fe in the lungs exacerbates the oxidative stress, triggered by the photocatalysis of ZnO, a situation that could occurs when welding galvanized steel. More broadly, this raises the question of the role of the Fenton mechanism in respiratory exposure to metal particles and its possible contribution to other lung diseases.
Association of cardiovascular health with the risk of dementia in older adults
Authors: Cho Seunghoon , Yang Pil-Sung , Kim Daehoon , You Seng Chan , Sung Jung-Hoon , Jang Eunsun , Yu Hee Tae , Kim Tae-Hoon , Pak Hui-Nam , Lee Moon-Hyoung , Joung Boyoung 
Published: September 2022

AbstractIt has been becoming important to identify modifiable risk factors to prevent dementia. We investigated the association of individual and combined cardiovascular health (CVH) on dementia risk in older adults. From the National Health Insurance Service of Korea-Senior database, 191,013 participants aged ≥ 65 years without prior dementia or cerebrovascular diseases who had check-ups between 2004 and 2012 were assessed. Participants were stratified into three groups according to the number of optimal levels of CVH (low, 0–2; moderate, 3–4; and high CVH status, 5–6) and grouped by levels of individual CVH metrics, the number of optimal CVH metrics, and the CVH score. Over a median follow-up of 6.2 years, 34,872 participants were diagnosed with dementia. Compared with low CVH status, moderate and high CVH status were associated with a decreased risk of dementia (hazard ratio [95% confidence interval], 0.91 [0.89–0.92] for moderate; 0.78 [0.75–0.80] for high CVH status) including Alzheimer’s and vascular dementia. The risk of dementia decreased with an increase in the number of optimal CVH metrics (0.94 [0.93–0.94] per additional optimal metric) and with an increase in the CVH score (0.93 [0.93–0.94] per 1-point increase). After censoring for stroke, the association of CVH metrics with dementia risk was consistently observed. Among individual metrics, physical activity had the strongest association with the risk of dementia. In an older Asian population without prior dementia or cerebrovascular disease, a consistent relationship was observed between the improvement of a composite metric of CVH and the reduced risk of dementia.
Induction immune-checkpoint inhibitors for resectable oncogene-mutant NSCLC: A multicenter pooled analysis
Authors: Zhang Chao , Chen Hua-Fei , Yan Shi , Wu Lin , Yan Li-Xu , Yan Xiao-Long , Yue Dong-Sheng , Xu Chun-Wei , Zheng Min , Li Ji-Sheng , Liu Si-Yang , Yang Ling-Ling , Jiang Ben-Yuan , Ou Qiu-Xiang , Qiu Zhen-Bin , Shao Yang , Wu Yi-Long , Zhong Wen-Zhao 
Published: September 2022

AbstractDespite limited efficacy of immunotherapy for advanced non-small-cell lung cancer (NSCLC) with driver mutations, whether neoadjuvant immunotherapy could be clinically valuable in those patients warrants further investigation. We utilized 40 oncogene-mutant NSCLC treated with induction immunotherapy from a large consecutive multicenter cohort. Overall response rate was 62.5% while 2 patients had disease progression. Of 39 patients that received surgery, R0 resection rate was 97.4%. The major pathological response (MPR) rate was 37.5% and the pathological complete response (pCR) rate was 12.5%. Pre-treatment PD-L1 expression was not a predictive biomarker in these patients. Median disease-free survival for all oncogenic mutation and EGFR mutation was 28.5 months. Indirect comparison through integrating CTONG1103 cohort showed neoadjuvant immunotherapy plus chemotherapy yielded the most superior efficacy among erlotinib and chemotherapy for resectable EGFR-mutant NSCLC. No MPR patients were identified with neoadjuvant immunotherapy plus chemotherapy for uncommon EGFR insertion or point mutations. Our results indicated the potential clinical feasibility of neoadjuvant immunotherapy for resectable localized oncogene-mutant NSCLC especially for EGFR-mutant NSCLC.
The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase
Authors: Khelashvili George , Kots Ekaterina , Cheng Xiaolu , Levine Michael V. , Weinstein Harel 
Published: September 2022

AbstractTMEM16F is a Ca2+-activated phospholipid scramblase in the TMEM16 family of membrane proteins. Unlike other TMEM16s exhibiting a membrane-exposed hydrophilic groove that serves as a translocation pathway for lipids, the experimentally determined structures of TMEM16F shows the groove in a closed conformation even under conditions of maximal scramblase activity. It is currently unknown if/how TMEM16F groove can open for lipid scrambling. Here we describe the analysis of ~400 µs all-atom molecular dynamics (MD) simulations of the TMEM16F revealing an allosteric mechanism leading to an open-groove, lipid scrambling competent state of the protein. The groove opens into a continuous hydrophilic conduit that is highly similar in structure to that seen in other activated scramblases. The allosteric pathway connects this opening to an observed destabilization of the Ca2+ ion bound at the distal site near the dimer interface, to the dynamics of specific protein regions that produces the open-groove state to scramble phospholipids.
Food system by-products upcycled in livestock and aquaculture feeds can increase global food supply
Authors: Sandström Vilma , Chrysafi Anna , Lamminen Marjukka , Troell Max , Jalava Mika , Piipponen Johannes , Siebert Stefan , van Hal Ollie , Virkki Vili , Kummu Matti 
Published: September 2022

AbstractMany livestock and aquaculture feeds compete for resources with food production. Increasing the use of food system by-products and residues as feed could reduce this competition. We gathered data on global food system material flows for crop, livestock and aquaculture production, focusing on feed use and the availability of by-products and residues. We then analysed the potential of replacing food-competing feedstuff—here cereals, whole fish, vegetable oils and pulses that account for 15% of total feed use—with food system by-products and residues. Considering the nutritional requirements of food-producing animals, including farmed aquatic species, this replacement could increase the current global food supply by up to 13% (10–16%) in terms of kcal and 15% (12–19%) in terms of protein content. Increasing the use of food system by-products as feed has considerable potential, particularly when combined with other measures, in the much-needed transition towards circular food systems.
Wildfire aerosol deposition likely amplified a summertime Arctic phytoplankton bloom
Authors: Ardyna Mathieu , Hamilton Douglas S. , Harmel Tristan , Lacour Léo , Bernstein Diana N. , Laliberté Julien , Horvat Christopher , Laxenaire Rémi , Mills Matthew M. , van Dijken Gert , Polyakov Igor , Claustre Hervé , Mahowald Natalie , Arrigo Kevin Robert 
Published: September 2022

AbstractSummertime wildfire activity is increasing in boreal forest and tundra ecosystems in the Northern Hemisphere. However, the impact of long range transport and deposition of wildfire aerosols on biogeochemical cycles in the Arctic Ocean is unknown. Here, we use satellite-based ocean color data, atmospheric modeling and back trajectory analysis to investigate the transport and fate of aerosols emitted from Siberian wildfires in summer 2014 and their potential impact on phytoplankton dynamics in the Arctic Ocean. We detect large phytoplankton blooms near the North Pole (up to 82°N in the eastern Eurasian Basin). Our analysis indicates that these blooms were induced by the northward plume transport and deposition of nutrient-bearing wildfire aerosols. We estimate that these highly stratified surface waters received large amounts of wildfire-derived nitrogen, which alleviated nutrient stress in the phytoplankton community and triggered an unusually large bloom event. Our findings suggest that changes in wildfire activity may strongly influence summertime productivity in the Arctic Ocean.
Ninety years of coastal monitoring reveals baseline and extreme ocean temperatures are increasing off the Finnish coast
Authors: Goebeler Norman , Norkko Alf , Norkko Joanna 
Published: September 2022

AbstractGlobal marine heatwave assessments often rely on satellite-derived sea surface temperature. However, these data have low accuracy in coastal areas, are unable to measure sub-surface temperatures and have only been available since the 1980s. Here, we analyse 90 years of in situ surface and bottom (30 m) water temperature data from a Finnish coastal monitoring site. Water temperatures were significantly higher between 1991–2020 than 1931–1960 and 1961–1990. We find strong differences between satellite-derived and in situ temperatures, with in situ temperatures being lower in autumn and winter and higher in spring. Measurements at the seafloor indicate marine heatwaves occurred during all seasons between 2016 and 2020, with intensities and durations exceeding previous records. Since the 1990s, we find an upward shift of the baseline temperature and increasingly frequent occurrence of temperatures previously considered as an extreme. Our findings highlight the importance of long-term in situ data and choice of climatological reference periods for assessing change.
Characterization and genome analysis of a psychrophilic methanotroph representing a ubiquitous Methylobacter spp. cluster in boreal lake ecosystems
Authors: Khanongnuch Ramita , Mangayil Rahul , Svenning Mette Marianne , Rissanen Antti Juhani 
Published: September 2022

Abstract
Lakes and ponds are considered as a major natural source of CH4 emissions, particularly during the ice-free period in boreal ecosystems. Aerobic methane-oxidizing bacteria (MOB), which utilize CH4 using oxygen as an electron acceptor, are one of the dominant microorganisms in the CH4-rich water columns. Metagenome-assembled genomes (MAGs) have revealed the genetic potential of MOB from boreal aquatic ecosystems for various microaerobic/anaerobic metabolic functions. However, experimental proof of these functions, i.e., organic acid production via fermentation, by lake MOB is lacking. In addition, psychrophilic (i.e., cold-loving) MOB and their CH4-oxidizing process have rarely been investigated. In this study, we isolated, provided a taxonomic description, and analyzed the genome of Methylobacter sp. S3L5C, a psychrophilic MOB, from a boreal lake in Finland. Based on phylogenomic comparisons to MAGs, Methylobacter sp. S3L5C represented a ubiquitous cluster of Methylobacter spp. in boreal aquatic ecosystems. At optimal temperatures (3–12 °C) and pH (6.8–8.3), the specific growth rates (µ) and CH4 utilization rate were in the range of 0.018–0.022 h−1 and 0.66–1.52 mmol l−1 d−1, respectively. In batch cultivation, the isolate could produce organic acids, and the concentrations were elevated after replenishing CH4 and air into the headspace. Up to 4.1 mM acetate, 0.02 mM malate, and 0.07 mM propionate were observed at the end of the test under optimal operational conditions. The results herein highlight the key role of Methylobacter spp. in regulating CH4 emissions and their potential to provide CH4-derived organic carbon compounds to surrounding heterotrophic microorganisms in cold ecosystems.
A low‐power and area‐efficient ultrasound receiver using beamforming successive approximation register analog‐to‐digital converter with capacitive digital‐to‐analog converter combined delay cell structure for 3‐D imaging systems
Authors: Lee Seungah , Yun Soohyun , Bae Joonsung 
Published: September 2022

AbstractThe authors present a low‐power area‐efficient subarray beamforming receiver (RX) structure for a miniaturized 3‐D ultrasound imaging system. Given that the delay‐and‐sum (DAS) and digitization functions consume most of the area and power in the receiver, the beamforming successive approximation register (SAR) analog‐to‐digital converter (ADC) shares its capacitive digital‐to‐analog converter (CDAC) with the delay cells. As a result, the delay cells implemented with capacitors are embedded in the CDAC with significant area reduction, further eliminating the need for power‐hungry ADC buffers. Furthermore, the dual reference 10‐bit SAR ADC reduces the area of CDAC by 32 times, achieving a switching energy reduction of 98.3%, compared to the conventional SAR ADC. As a result, the proposed beamforming SAR ADC, simulated using a 0.18 μm CMOS process, consumes 230 μW per channel, significantly reducing the per channel capacitance.
A self‐driven synchronous rectification wide‐range ZVS single‐switch forward converter controlled using the variable inductance
Authors: Ghavidel Jalise Mahdi , Allahyari Hesamodin , Shoaei Aran , Adib Ehsan , Bahrami Hamid , Latif Zadeh Mohammad Ali , Fahimifar Mohammad Hossein 
Published: September 2022

AbstractA new single switch ZVS forward converter with a wide soft‐switching range is proposed here. Compared to the conventional forward converter, the proposed converter uses fewer components and operates under ZVS soft switching. A capacitor, along with both the leakage and magnetizing inductances, provides ZVS soft switching and transformer core reset. To regulate the output voltage against the input voltage and the load variations, an inductor is added to the converter. The inductance of the additional inductor varies with the direct current (DC) of the DC bias winding to regulate the output voltage. Therefore, the duty cycle and the switching frequency are constant in the proposed converter. With the constant duty cycle and the constant switching frequency, the wide ZVS soft switching is achieved. The proposed converter is completely analysed theoretically. The finite element analysis is used to design the additional inductor. By designing an experimental prototype, the theoretical analysis is justified using the experimental results.
Wanted: A name for a commonly used trigonometry function
Authors: Koks Don 
Published: September 2022

AbstractExcept in trivial cases, an unknown angle is always extracted from a knowledge of its sine and cosine. These two numbers determine the angle unambiguously; and yet no universally accepted notation expresses that angle as a function of those numbers in a single statement. Some authors use “atan2” for this purpose. I argue that this name is not appropriate, and its description as a “four‐quadrant inverse tangent” is misleading. I propose two interchangeable names “” as candidates for the sought‐after function.
Comparison of the effect of reporting cytoplasmic patterns as
anti-nuclear antibody positive and anti-nuclear antibody negative on reflex test
ordering
Authors: Uyar Neval Yurttutan 
Published: September 2022

Abstract
Objective Anti-nuclear antibody (ANA) patterns are classified as nuclear,
cytoplasmic or mitotic. The International Consensus on ANA patterns (ICAP)
suggests three parameters for ANA reporting – assay type, results and
advice for reflex testing – but has not yet reached a consensus on the
reporting of cytoplasmic/mitotic patterns as ANA-negative or positive.
We investigated the effect of ICAP’s two proposals for reporting
cytoplasmic patterns as ANA-positive and negative with a view to the
recommendation for reflex testing in a country that has no national
reimbursement policies for automatic reflex testing.
Methods This non-interventional descriptive study included 1241 patients
with positive cytoplasmic ANA patterns. 442 patients were reported as
ANA-negative and 799 as ANA-positive. Patients were followed up for a two-year
period to determine testing recommendations based upon nuclear and cytoplasmic
patterns. For statistical analysis, the t-test was used, with a significance
threshold of p-value<0.05.
Results Appropriate reflex orders were seen more commonly with cytoplasmic
patterns reported as ANA-positive (27.30%) than with those reported as
ANA-negative (5.51%, p-value<0.05). However, ANA-positive
reports led to higher ordering of nuclear pattern reflex tests (12.97%)
compared with ANA-negative reports (1.10%, p-value<0.05). A
large group of patients (59.73% ANA-positive, 93.39%
ANA-negative) did not receive reflex testing.
Conclusion Reporting cytoplasmic patterns as ANA-positive was considered
more significant, but reading the result report without considering the pattern
and recommendation notes could lead to inappropriate reflex testing. Besides
reaching a consensus for reporting cytoplasmic patterns as ANA-negative or
positive, it is important to consider solutions to reimbursement policies for
automatic reflex testing to decrease the impediments in reporting cytoplasmic
ANA patterns.
Mucocele of the Appendix: A Presentation
Authors: Singh Mahendra Pratap , Huda Tanweerul 
Published: September 2022

AbstractThe mucocele of the appendix can be described as an obstructive dilatation of the appendix by an intraluminal accumulation of mucus. A 60-year-old diabetic male patient presented with chief complains of pain in right lower abdomen for the past 2 months which was dull in nature, not associated with fever, vomiting, diarrhea, constipation, or any urinary complains. Contrast-enhanced computed tomography (CECT) of the abdomen revealed appendiceal lumen distended, filled with fluid collection. There was abrupt narrowing seen at its junction with cecum. Features were suggestive of appendicular mucocele. The patient was taken up for exploratory laparotomy, and a distended turgid appendix, around 4 cm in diameter with dilated cecum, was found. Ileocecal resection was done followed by ileo-ascending colon side-to-side anastomosis using staplers. The histopathological examination report revealed an R0 resection. The patient was followed up for 3 years postoperatively with CECT of the abdomen and a colonoscopy yearly. There was no evidence of any recurrence in the follow-up.
Chest HRCT Assessment of COVID-19 Patients in Vaccinated versus Nonvaccinated Patients: A Comparative Study in a Tertiary Care Hospital
Authors: Mendiratta Kuldeep , Solanki Shubham , Rathi Bhavyansh , Bhandari Sudhir , Bellamkondi Ashwini , Parihar Bineeta Singh , Singh Apoorva , Parakh Pradeep 
Published: September 2022

AbstractCoronavirus disease 2019 (COVID-19) has turned out to be the most devastating viral disease that the world has encountered for the past century. The World Health Organization (WHO) declared it a pandemic on March 11, 2020. The disease mainly spreads through respiratory droplets which makes social distancing a primary tool of prevention. Many variant strains have emerged up since the pandemic started and the Delta variant is responsible for recent surge of cases in second wave of COVID-19 in India. Mass vaccination is the most efficacious precautionary measure that can be applied to stop the transmission and generate herd immunity. Vaccination does not give 100% prevention from infection, but it halts the severity of infection. Vaccine is the boon amidst the mayhem. Our study highlights that those vaccinated (particularly two doses) had clinically mild symptoms and mild computed tomography severity score (CTSS) with a speedy recovery. Those unvaccinated had moderate to severe symptoms with moderate to severe CTSS (>8) often requiring hospital admission and having poor prognosis. Thus, vaccine helps reduce the health burden of the already strained health care system. Immunization visit can also be used as an opportunity to disseminate message to encourage behavior, to reduce transmission risk of COVID-19 virus, to identify the signs and symptoms of disease, and to provide guidance on what to do.