bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying to a nursing home is a way to maintain control of life—Experiences from Swedish nursing home applicants
Authors: Spang Lisa , Holmefur Marie , Hermansson Liselotte , Lidström Holmqvist Kajsa 
Published: July 2022

AbstractBackgroundSwedish social policy enables ageing in place with support from home‐based care services despite high age and/or declining health.AimThis study aims to describe the daily life experiences behind the decision to apply for a nursing home placement in older adults ageing in place.Materials and MethodsA qualitative design was chosen, and 11 semi‐structured interviews were conducted and analysed using inductive qualitative content analysis.ResultsThe participants described a feeling of dependence in which they had to ignore their personal privacy when receiving home‐based care. They reached a turning point when ageing in place was, for several reasons, no longer considered an acceptable option. This influenced their choice to apply to a nursing home where they expected that they could maintain control over their lives.Discussion and ConclusionThe results indicate that when enhancing ageing in place it is important to enable older adults to receive support to maintain autonomy in daily activities and to have the opportunity to age in the right place.
Immune surveillance in glioblastoma: Role of the NKG2D system and novel cell‐based therapeutic approaches
Authors: Chitadze Guranda , Kabelitz Dieter 
Published: July 2022

AbstractGlioblastoma, formerly known as glioblastoma multiforme (GBM), is the most frequent and most aggressive brain tumour in adults. The brain is an immunopriviledged organ, and the blood‐brain barrier shields the brain from immune surveillance. In this review, we discuss the composition of the immunosuppressive tumour micromilieu and potential immune escape mechanisms in GBM. In this respect, we focus on the role of the NKG2D receptor/ligand system. NKG2D ligands are frequently expressed on GBM tumour cells and can activate NKG2D‐expressing killer cells including NK cells and γδ T cells. Soluble NKG2D ligands, however, contribute to tumour escape from immunological attack. We also discuss the current immunotherapeutic strategies to improve the survival of GBM patients. Such approaches include the modulation of the NKG2D receptor/ligand system, the application of checkpoint inhibitors, the adoptive transfer of ex vivo expanded and/or modified immune cells or the application of antibodies and antibody constructs to target cytotoxic effector cells in vivo. In view of the multitude of pursued strategies, there is hope for improved overall survival of GBM patients in the future.
Likeminded? Congruence Between Political Elites and their Voters Regarding Policy Choices inSwiss‐EURelations
Authors: Lauener Lukas 
Published: July 2022

AbstractSwiss‐EU relations not only rank among the most important political problems for citizens but are also the subject of repeated political contestation. Using data from the 2019 Swiss Election Study (Selects), this article examines the extent to which the opinions of political elites and voters coincide on four European integration issues: 1) the trade‐off between maintaining the bilateral agreements and limiting immigration, 2) the cohesion billion, 3) the trade‐off between the institutional framework agreement and the accompanying measures, and 4) EU membership. The results show that, overall, candidates represent voters extremely well with regard topositions, i.e., both groups are “on the same side”. However, candidates are generally more EU‐integrationist and hold more extreme opinions than voters. Moreover, this article investigates how well candidates represent thevarietyof voter opinions and finds that – contrary to previous research – there is no systematic difference between centrist and pole parties.
A pan‐genome and chromosome‐length reference genome of narrow‐leafed lupin (Lupinus angustifolius) reveals genomic diversity and insights into key industry and biological traits
Authors: Garg Gagan , Kamphuis Lars G. , Bayer Philipp E. , Kaur Parwinder , Dudchenko Olga , Taylor Candy M. , Frick Karen M. , Foley Rhonda C. , Gao Ling‐Ling , Aiden Erez Lieberman , Edwards David , Singh Karam B. 
Published: July 2022

SUMMARYNarrow‐leafed lupin (NLL; Lupinus angustifolius) is a key rotational crop for sustainable farming systems, whose grain is high in protein content. It is a gluten‐free, non‐genetically modified, alternative protein source to soybean (Glycine max) and as such has gained interest as a human food ingredient. Here, we present a chromosome‐length reference genome for the species and a pan‐genome assembly comprising 55 NLL lines, including Australian and European cultivars, breeding lines and wild accessions. We present the core and variable genes for the species and report on the absence of essential mycorrhizal associated genes. The genome and pan‐genomes of NLL and its close relative white lupin (Lupinus albus) are compared. Furthermore, we provide additional evidence supporting LaRAP2‐7 as the key alkaloid regulatory gene for NLL and demonstrate the NLL genome is underrepresented in classical NLR disease resistance genes compared to other sequenced legume species. The NLL genomic resources generated here coupled with previously generated RNA sequencing datasets provide new opportunities to fast‐track lupin crop improvement.
Family–level phylogeny of infraorder Systellognatha (Insecta: Plecoptera) inferred from mitochondrial genomes
Authors: Wang Ying , Cao Jinjun , Murányi Dávid , Guo Xuan , Guo Caiyue , Li Weihai 
Published: July 2022

AbstractSystellognatha is a monophyletic group within stoneflies containing seven families in two superfamilies. However, the family–level phylogeny within Systellognatha is largely unresolved, with some controversial hypotheses generated by molecular data. In this study, we sequenced one complete and three nearly complete mitochondrial genomes (mitogenomes) representing three systellognathan families (including one newly described family), to recover the phylogeny of all seven extant systellognathan families. We tested the effect of heterogeneous sequence divergence within mitogenome sequences on phylogenetic reconstruction. To study incongruent topologies supported by different datasets, we also utilized four–cluster likelihood mapping to elucidate these phylogenetic questions. We found a low degree of compositional heterogeneity in systellognathan mitogenomes. Our results showed that phylogenetic analyses with various datasets under site–homogeneous models failed to recover the Perloidea and Pteronarcyoidea as monophyletic groups. However, Bayesian inference with a site–heterogeneous model (CAT + GTR) recovered Perloidea as monophyletic. Our results confirm a sister–group relationship between Chloroperlidae and Perlodidae. Despite all phylogenetic analyses failed to recover the Pteronarcyoidea as monophyletic, the analyses with site–heterogeneous model based on PCG12, PCG12R and PCGR datasets reconstructed the same relationships among Pteronarcyidae, Peltoperlidae, Styloperlidae and Perloidea. Our study shows the power of the site–heterogeneous models in resolving phylogeny within Systellognatha and provides a new insight into the phylogeny of this group.
Giant deep submarine depressions: A combined dissolution-mechanical process along carbonate margins
Authors: Mulder T. , Cavailhes T. , Hanquiez V. , Gillet H. , Recouvreur A. , Fabregas N. 
Published: July 2022

AbstractSubmarine depressions are common features on the eastern Bahamian seafloor but the genesis of the deepest ones (&gt;4000 m in water depth) is not well understood. We conducted a morphometric analysis and compared them to a worldwide database of rounded depressions, whatever their genesis is. The deep Bahamian depressions are large elongated structures, among the largest on Earth, with a width greater than 1000 m and a depth sometimes greater than 200 m. They extend at the toe of the Blake Bahama Escarpment (BBE), one of the tallest escarpments on Earth. Some of them align parallel to the BBE. Other depressions align along large submarine canyon axes. When aligned along canyon axes, the depressions closest to the canyon head are flanked by a topographic high interpreted as a slope-break deposit, i.e., sediment deposited after flow expansion following a hydraulic jump. Turbidity currents in the carbonate canyon system are not permanent processes, but are rather triggered during sea-level highstands when the carbonate platform is flooded. In addition, some depressions are not located in canyon axes. Consequently, the size and location of the depressions are not likely explained by a simple plunge pool mechanical erosion. Rather, our data suggest that all depressions could be initiated by giant karstic dissolution structures (dolines or sinkholes). Under interpretation, those located in canyon axes are sporadically refreshed by carbonate-laden turbidity currents. The height of the outsized chutes marking the crossing of the BBE by the canyon mouth generates a hydraulic jump allowing sediment deposition toward the bottom of the depression. Large depressions observed at this location in the Bahamas were the result of an initial dissolution phase related to retreat of the BBE and the more recent sediment-laden flow activity. The depressions orientated along canyon axes facilitated the regressive erosion that formed the canyons. At present, the depressions located at canyon mouths act as regular plunge pools.
Portomesenteric Vein Thrombosis After Laparoscopic Sleeve Gastrectomy: A Single-Institution Report
Authors: Wilkinson Lily , Aubry Staci T. , Haskins Ivy N. , Duke Meredith C. , Moll Stephan , Dixon Robert , Farrell Timothy M. 
Published: July 2022

Laparoscopic sleeve gastrectomy (LSG) is an effective weight-loss operation. Portomesenteric vein thrombosis (PMVT) is an important complication of LSG. We identified four cases of PMVT after LSG at our institution in women aged 36-47 with BMIs ranging from 44-48 kg/m2. All presented 8-19 days postoperatively. Common symptoms were nausea, vomiting, and abdominal pain. Thrombotic risk factors were previous deep vein thrombosis and oral contraceptive use. Management included therapeutic anti-coagulation, directed thrombolysis, and surgery. Complications were readmission, bowel resection, and bleeding. Discharge recommendations ranged from 3-6 months of anticoagulation using various anticoagulants. No consensus was reached on post-treatment hypercoagulable work up or imaging. All cases required multi-disciplinary approach with Surgery, Interventional Radiology, and Hematology. As PMVT is a rare but potentially morbid complication of LSG, further development of tools that quantify preoperative thrombotic risk and clear guidance regarding use of anticoagulants are needed for prevention and treatment of PMVT following LSG.
Clinical correlates of comorbid attention deficit hyperactivity disorder in adults suffering from bipolar disorder: A meta-analysis
Authors: Bartoli Francesco , Callovini Tommaso , Cavaleri Daniele , Cioni Riccardo Matteo , Bachi Bianca , Calabrese Angela , Moretti Federico , Canestro Aurelia , Morreale Marco , Nasti Christian , Palpella Dario , Piacenti Susanna , Nacinovich Renata , Riboldi Ilaria , Crocamo Cristina , Carrà Giuseppe 
Published: July 2022

Objective: Attention deficit hyperactivity disorder is a frequent comorbid condition in adults with bipolar disorder. We performed a meta-analysis aimed at assessing sociodemographic and clinical correlates of attention deficit hyperactivity disorder in bipolar disorder. Method: We searched main electronic databases up to June 2021. Random-effects meta-analyses, with relevant meta-regression and quality-based sensitivity analyses, were carried out to estimate the association between attention deficit hyperactivity disorder and putative correlates, grading the quality of evidence. Results: We included 43 studies, based on 38 independent samples. Attention deficit hyperactivity disorder participants were more likely to be males (odds ratio = 1.46; p < 0.001) and unemployed (odds ratio = 1.45; p = 0.045), and less likely to be married (odds ratio = 0.62; p = 0.014). They had an earlier onset of bipolar disorder (standardized mean difference = −0.36; p < 0.001); more mood episodes (standardized mean difference = 0.35; p = 0.007), particularly depressive (standardized mean difference = 0.30; p = 0.011) and mixed (standardized mean difference = 0.30; p = 0.031) ones; higher odds of using antidepressants (odds ratio = 1.80; p = 0.024) and attempted suicides (odds ratio = 1.83; p < 0.001) and lower odds of psychotic features (odds ratio = 0.63; p = 0.010). Moreover, they were more likely to have generalized anxiety disorder (odds ratio = 1.50; p = 0.019), panic disorder (odds ratio = 1.89; p < 0.001), social phobia (odds ratio = 1.61; p = 0.017), eating disorders (odds ratio = 1.91; p = 0.007), antisocial personality disorder (odds ratio = 3.59; p = 0.004) and substance (odds ratio = 2.29; p < 0.001) or alcohol (odds ratio = 2.28; p < 0.001) use disorders. Quality of the evidence was generally low or very low for the majority of correlates, except for bipolar disorder onset and alcohol/substance use disorders (high), and suicide attempts (moderate). Conclusion: Comorbid bipolar disorder/attention deficit hyperactivity disorder may have some distinctive clinical features including an earlier onset of bipolar disorder and higher comorbid alcohol/substance use disorder rates. Further research is needed to identify additional clinical characteristics of this comorbidity.
Results of contralateral anastomosis of microvascular free flaps in head and neck reconstruction
Authors: Gschossmann Juliane D. , Balk Matthias , Rupp Robin , Müller Sarina K. , Allner Moritz , Sievert Matti , Mantsopoulos Konstantinos , Koch Michael , Iro Heinrich , Gostian Antoniu O. 
Published: July 2022

Objectives Despite various solutions to the issue of ipsilateral vessel-depleted neck in microvascular head and neck reconstruction, concrete data on its safety and implementation are scarce. This paper focuses on the feasibility and success rates of contralateral anastomosis in free flap reconstruction in the head and neck region. Methods This single-center retrospective study at a tertiary referral center includes all patients who underwent free flap reconstruction of the head and neck with contralateral anastomosis between January 1st, 2007 and February 28th, 2021. Primary objectives were frequency, success, and flap-associated complication rates. Secondary objectives were recipient vessels and flap type. Results Of 318 patients who underwent microvascular reconstruction, anastomosis was performed on the contralateral side of the neck in 32 patients (10.0%). Recipient vessels involved mainly the superior thyroid artery (74.2%; n = 23) and the facial vein (51.1%; n = 23). Thirty patients (93.8%) received a radial forearm free flap. Flap-associated complications occurred in 12.5% of included cases (n = 4): one partial flap necrosis (3.1%), one anastomotic insufficiency (3.1%), one venous thrombosis of the microvascular pedicle (3.1%), and one wound dehiscence (3.1%). All of these complications were resolved without complete flap loss. Conclusion This study demonstrates that contralateral anastomosis is a successful and safe option in microvascular head and neck reconstruction, especially using a radial forearm free flap. Thus, anastomosing to the contralateral side of the neck can be advocated as a valuable option in the ipsilateral vessel-depleted neck.
Building Civic Capacity: The History and Landscape of NYC Integration Activism, 2012–2021
Authors: Debs Mira , Makris Molly Vollman , Castillo Elise , Rodriguez Alexander , Smith Ayana , Ingall Josephine Steuer 
Published: July 2022

Background: New York City is one of the most segregated school districts in the country, but between 2012 and 2021, school integration moved from a marginal to a central education policy. Existing narratives have emphasized the efforts of parents and school and political leaders, with less attention given to the significance of citywide coalitions of activists, especially youth activists. Purpose: We examine how grassroots activists contributed to advancing school integration policy, and the opportunities and challenges that resulted, through urban regime theory, and specifically civic capacity, which highlights how various constituencies build a shared agenda for policy change. Research Design: Working in partnership with four youth interviewers at two integration activist organizations, we conducted 72 semi-structured interviews with New York City student, parent, and community activists. We also observed 36 hours of public meeting observations and collected publicly available documents, including 360 newspaper articles and policy documents, to triangulate our findings. Conclusions: We found that activist coalitions made progress in developing civic capacity through increased collaboration among diverse stakeholders, notably youth, toward a shared definition of integration. However, growing tensions with rival coalitions and the fragmented political landscape of NYC limited the strength and durability of civic capacity.
Preventative effects of antioxidants on changes in sebocytes, outer root sheath cells, and Cutibacterium acnes-pretreated mice by particulate matter: No significant difference among antioxidants
Authors: Kwack Mi Hee , Ha Dae-Lyong , Lee Weon Ju 
Published: July 2022

Objectives Particulate matter (PM) is an air pollutant that can damage human skin; antioxidants have shown some efficacy in alleviating PM-induced skin inflammation. We investigated the antioxidant effects of punicalagin, epigallocatechin-3-gallate (EGCG), and resveratrol on PM-induced changes in cultured human sebocytes, outer root sheath (ORS) cells, and Cutibacterium acnes-pretreated mice. Methods Sebocytes and ORS cells were cultured with 100 μg/mL PM10 and 5 μM punicalagin, 1 μM EGCG, or 1 μM resveratrol for 24 h. In C. acnes-pretreated mice, inflammatory nodules were treated with 100 μg/mL PM10 and 5 μM punicalagin, 1 μM EGCG, or 1 μM resveratrol. Cell viability was measured using an MTT assay. Antioxidant effects were analyzed according to RNA expression, using real-time PCR, as well as reactive oxygen species (ROS) and sebum measurements. Results Antioxidants inhibited the upregulation of inflammatory cytokines, matrix metalloproteinase, aryl hydrocarbon receptor, and NF-kB as well as the production of ROS induced by PM10 in cultured sebocytes and ORS cells. The preventative effects of punicalagin and EGCG on biomarker expression in cultured sebocytes and ORS cells were slightly greater than those of resveratrol, though the difference was not significant. In C. acnes-pretreated mice, the antioxidants inhibited inflammatory cytokine and matrix metalloproteinase expression as well as sebum production. Conclusions Antioxidants effectively reduced the expression of inflammatory biomarkers and sebum production in cultured sebocytes, ORS cells, and C. acnes-pretreated mice.
The association between dietary patterns and a doctor diagnosis of systemic lupus erythematosus: the Adventist Health Study-2
Authors: Oh Jisoo , Oda Keiji , Brash Marissa , Beeson W. Lawrence , Sabaté Joan , Fraser Gary E , Knutsen Synnove F 
Published: July 2022

Objective The aim of our study was to assess the association between a diagnosis of Systemic Lupus Erythematosus (SLE) and dietary pattern as well as demographic factors among subjects in the Adventist Health Study-2 (AHS-2) cohort. Methods Multivariable logistic regression modeling was used to assess the association between prevalence of self-reported SLE and dietary patterns (vegetarian, pesco-vegetarian and non-vegetarian). Potential confounding variables included were age, gender, race, education, and smoking history among 77,795 AHS-2 participants. Results There was a dose-response association between the prevalence of SLE with vegetarian diets, ordered by content of animal meats. The stricter vegetarians had 25% lower odds of reporting that they were currently being treated for SLE (OR = 0.75, 95% CI 0.56, 1.02) with intermediate levels for the pesco-vegetarians who eat fish (OR 0.88, 95% CI 0.57, 1.36), compared to non-vegetarians. As expected, there were also significant associations between the prevalence of SLE with sex, race, age, and smoking. Significantly fewer men were diagnosed with SLE compared to women (OR = 0.14, 95% CI: 0.08, 0.22). Compared to non-Hispanic Whites, non-Hispanic Blacks were significantly more likely to report a diagnosis of SLE (OR 1.69, 95% CI 1.29, 2.21). A significantly lower proportion of 30–39 year olds (OR 0.51, 95% CI 0.29, 0.90) reported a diagnosis of SLE when compared to those 60 or older. Also, ever smokers were more likely to report prevalent SLE than those who had never smoked (OR 1.71, 95% CI 1.27, 2.31). Conclusion We found that vegetarians had lower odds of doctor-diagnosed SLE with an increasing trend in prevalence from stricter vegetarians to pesco-vegetarians to non-vegetarians. We also note that the association with other demographic factors in AHS-2 was similar to that found in other studies. Future studies may focus on assessing the incidence and severity of the disease among vegetarians and non-vegetarians.
Incidence of Lateral Prominence Pain Following Open Medial Displacement Calcaneal Osteotomy and the Efficacy of Crushplasty as a Preventive Technique
Authors: Kim Jaeyoung , Kim Chul-Ho , Day Jonathan , Seilern und Aspang Jesse , Rajan Lavan , Kumar Prashanth 
Published: July 2022

Background: There has been concern about lateral prominence pain at the osteotomy site following medial displacement calcaneal osteotomy (MDCO). However, no study has investigated this complication. This study aimed to investigate the incidence of lateral prominence pain following MDCO and examine the efficacy of crushplasty as a surgical technique to minimize this complication. Methods: This was a retrospective cohort study in which 137 patients (148 feet) who underwent MDCO were divided into 2 groups by whether they had concurrent crushplasty at the time of MDCO (crushplasty [n = 81] vs noncrushplasty group [n = 67]). Crushplasty was performed by flattening the bony step-off using a rongeur and bone impactor. Lateral prominence pain was defined as pain or irritating symptoms over the osteotomy site that persisted over 12 months after MDCO. The overall incidence of lateral prominence pain after MDCO and within each group was investigated. Multiple logistic regression analysis was used to determine the influence of possible risk factors on the development of postoperative lateral prominence pain. Results: The overall incidence of lateral prominence pain was 9.5% (14 of 148): 3.4% (3 of 87) in the crushplasty group, and 18% (11 of 61) in the noncrushplasty group, and χ2 analysis showed a statistically significant relationship between crushplasty and lateral prominence pain ( P < .05). A relationship between the amount of medial displacement and the development of lateral prominence pain was observed in the noncrushplasty group (OR = 5.31, 95% CI 2.35-16.4, P < .05), but this was not observed in the crushplasty group ( P = .641). The amount of medial displacement was an independent risk factor for the development of lateral prominence pain (OR = 2.72, 95% CI 1.54-4.79, P < .05), and concurrent crushplasty had a negative relationship with lateral prominence pain development (OR = 0.12, 95% CI 0.03-0.57, P < .05). Conclusion: This study revealed that lateral prominence pain is a significant complication of MDCO, especially in the setting of a larger displacement. The crushplasty following MDCO may minimize this complication, particularly when a greater degree of hindfoot correction is attempted.