bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel RoF System Integrating Optical Fiber and FSO Channel with Polarization Multiplexing PAM4 Downlink Signals
Authors: Shao Yufeng , Tian Qing , Wang Anrong , Yu Ni , Yang Qiming , Yi Linfang , Yuan Jie , Li Yanlin , Chen Peng , Li Chong , Liu Shuanfan , Zuo Renjie 
Published: December 2022

Abstract
A novel radio over fiber (RoF) system with polarization multiplexing 4-ary pulse amplitude modulation (PAM4) downlink signals is proposed and designed. The generated downstream signal is transmitted over 25km smf-28 and 100m optical wireless channel. The 60GHz millimeter-wave is generated by the beating of two continuous light waves, and the high frequency signal is demodulated by using self-mixing detection method. We analyzed the transceiver and transmission performance of the introduced polarization multiplexing RoF-FSO system. The results demonstrate this scheme can effectively improve the spectral efficiency of downlink broadband access signals, and be applied in the future broadband access network.
Basigin interacts with majority of the erythrocyte binding Pvfam ‘a’ family proteins of Plasmodium vivax to assist parasite entry into host cell
Authors: Tripathi Manish , Santoshi Meghna , Sharma Yagya D. , Rathore Sumit 
Published: December 2022

Abstract
Molecular mechanisms of red cell invasion by the Plasmodium vivax parasite remain obscure since information on receptor-ligand interaction is scarce. Our lab had identified Basigin as receptor molecule for one of the important members of Pvfam “a’ family protein i.e., PvTRAg38. Here, we demonstrate by using solid phase binding assay, and Surface Plasmon Resonance that seven out of ten-erythrocyte binding Pvfam ‘a’ family proteins of P. vivax interact with erythrocyte receptor Basigin. This receptor-ligand interaction seems to be important for parasite’s survival since each of these proteins interfered with the parasite growth in a heterologous culture system. Furthermore, a higher parasite growth inhibition rate was achieved with combination of proteins suggesting the significance of multiple parasite ligands interaction with the same erythrocyte receptor during invasion process. These results will be helpful in understanding P. vivax biology and developing the therapeutics for vivax malaria.
Interdecadal Variations and Causes of the Relationship Between the winter East Asian Monsoon and Interhemispheric Atmospheric Mass Oscillation
Authors: Lu Chuhan , Zhong Lei , Guan Zhaoyong , Qiao Nian 
Published: December 2022

Abstract
Under the background of global warming, East Asia has been frequently affected by large-scale persistent extreme cold events in winter in recent years. As the most important circulation system affecting the East Asian winter climate, especially the temperature anomaly, the East Asian winter monsoon (EAWM) is affected by changes in semipermanent atmospheric activity centres such as the Siberian high and the Aleutian low. We found that there has been a significant positive correlation between the EAWM and Interhemispheric Oscillation (IHO). However, conspicuous interdecadal variations have occurred in the relationship between the EAWM and IHO. The relationship between the IHO and EAWM was most significant during 1979–2020, but this relationship was weak and insignificant during 1962–1978. During 1979–2020, the atmospheric mass (surface pressure) difference between the Northern Hemisphere (NH) and Southern Hemisphere (SH) during 1979–2020 was significantly reduced by 7.85% (0.75×1015 kg) compared with that during 1962–1978. Such interhemispheric redistribution of atmospheric mass (AM) has had a distinct impact on the land‒sea pressure contrast in East Asia and has intensified the connection between the EAWM and IHO. A strengthened EAWM has resulted in notable cooling and more severe winters in China. The apparent exportation of AM in the Antarctic region is an important driving factor for this interhemispheric change. The accompanying anomalous accumulation of AM in the Northern Hemisphere is linked with an increase in the pressure difference between land and sea in East Asia, resulting in intensifying correlation between IHO and the EAWM. The decadal enhancement of the IHO during 1979–2020 was closely connected with conspicuous warming in the tropical troposphere/lower stratosphere (UTLS). A seesaw pattern of anomalous air temperature and ozone between tropical and Antarctic UTLS has induced a decrease in Antarctic ozone masses and air temperature and has strengthened the polar vortex, corresponding to a decadal enhancement of interhemispheric AM imbalance.
Improving UWB Ranging Accuracy via Multiple Network Model with Second Order Motion Prediction
Authors: Xing Guangwei , Guo Yanrong , Chen Xiaoxuan , Luo Hangzai , Zhong Sheng 
Published: December 2022

Abstract
With the wide application of ultra-wideband (UWB) ranging technology in industry, production and aerospace, how to improve the accuracy of UWB ranging has become a research hotspot. If the UWB ranging data is treated as sequence data, it is possible to improve the ranging performance by sequence analysis, which has low computation complexity compared to direct UWB signal processing. However, as the UWB ranging data has its inherent properties, existing sequence analysis methods may not achieve good performance on UWB ranging data. In this paper, a two-path deep-learning framework to process, namely the Multiple Network model with Second order motion (MNS), is proposed the improve UWB ranging performance via ranging sequence analysis. The proposed method fuses the target motion prediction via Newton's laws of motion and error estimation via GRU, LSTM and Bayes. To evaluate our algorithm, we also proposed a method to collect both UWB ranging data and the accurate answer via laser ranging. The collected dataset DATA_TS, the proposed MNS algorithm, and the trained model are all open sourced to the community to help researchers for further research,please visit https://github.com/xiaojiuwotongxue/data-store.git. Experiments on DATA_TS shows our proposed method outperforms traditional regresion methods significantly.
Ground-layer vegetation of cleared woodlands (pastures) has lower biodiversity and different invertebrate assemblages to remnant woodlands in grazed landscapes of eastern Australia
Authors: Houston Wayne A. , Black Robert L. , Wormington Kevin R. 
Published: December 2022

Abstract

Introduction: Clearing of woodlands is used by graziers to promote pasture production, even though understanding of impacts of clearing on native fauna is lacking. Aim/Methods: To evaluate impacts of clearing on biodiversity by comparing invertebrates associated with ground-layer vegetation in pastures to that of nearby uncleared woodlands. Two replicates of cleared woodlands (pastures) were compared with two woodlands at each of four locations. The adjacent riparian forest to each pasture and woodland site provided a geographic control, making four habitats. Invertebrates of ground-layer vegetation were sampled using three suction subsamples of 1m2 at each site. Results: Pastures had significantly lower order richness, herbivores, pollinators and macroinvertebrates (food for birds) than the woodlands, whereas the riparian forests closely resembled each other in all metrics. Invertebrate assemblages of pastures also differed from those of the woodlands, groundcover and leaf-litter correlating strongest with invertebrate composition. Discussion: Findings of this study contrasted with another in recently cleared woodlands where few differences were observed. Our study differed in the much longer period since clearing (> 20 years cf. 5 years) and the dominance by introduced grasses (> 40% cover in pastures cf. <15% in woodlands) rather than native grasses. Implications for insect conservation: Pastoralists have the capacity to improve outcomes for invertebrate biodiversity by maintaining groundcover above 80%, by encouraging native pastures over introduced species such as Buffel Grass and by retaining native woodlands. Biodiverse invertebrates benefit graziers by contributing to soil health, food webs that support pest control, pollination, herbivory of weeds and sustainable grass production.
Effects of Polyion Adsorption on Surface Properties of TiO2
Authors: Jukić Jasmina , Juračić Tea , Josić Eva , Namjesnik Danijel , Begović Tajana 
Published: December 2022

Abstract
Adsorption of polyions, strongly charged poly(N-ethyl-4-vinylpyridinium) cation (P4VP) weakly charged poly(allylammonium) cation (PAH) and weakly charged poly(acrylate) anion (PAA) on TiO2 surface was investigated. The selected polyions have different functional groups and degree of polyion ionization, which affects the interactions with the TiO2 surface. The effect of polyion adsorption on the inner surface potential and the electrokinetic potential were measured and analyzed. The inner surface potential of TiO2 was measured by means of single crystal (SCr) electrodes with two different crystal orientation (001) and (100). The electrokinetic potential of titania particles was obtained from electrophoretic measurements. In suspensions, uncoated TiO2 particles tend to aggregate and aggregation is reduced after polyion adsorption. The process of aggregation was monitored measuring the size of the particles. Since the surface charge of TiO2 and the degree of polyion ionization depend on the composition of the solution, namely on pH and ionic strength, the adsorption of polyions on TiO2 also depends on these parameters. The contribution of the surface charge and degree of polyion ionization of the selected polyelectrolytes to the rate of aggregation of TiO2 particles was examined. It was found that in the case of weak polyelectrolyte the degree of polyanion ionization plays significant role in stabilization of titania suspensions.
A Fundamental Question of Counting in Association Rules
Authors: Bodoff David , Goldman Marina Feldus 
Published: December 2022

Abstract

Association Rules (AR) are widely used for data mining in industry, and have been extensively researched in academia. An elementary step in the calculation of the strength of each proposed rule X -> Y is the tabulation of occurrences and co-occurrences of X and Y. Yet, a fundamental question does not appear to have received attention in the literature. The question is, how should one count these occurrences? Nearly all researchers and practitioners use one method, but there is actually an alternative way to count, and the data mining literature has not seriously considered the alternative or justified the prevailing choice. This fundamental question of counting is not a purely theoretical difference; the methods yield different results. In this research, we investigate the implications of the two methods. Results include the following: (1) Both methods can be correct under a different probabilistic setup; (2) The two counting methods yield different results, in terms of the relative order of rules when ranked by strength; (3) The extent to which the methods diverge depends on properties of the data, one of which we identify; (4) The methods can be compared based on their properties, one of which we investigate. The contribution of our work is that it brings to light a technical choice that impacts results, and provides a few bases upon which a researcher or practitioner can make a principled choice of which method to use when employing AR.
Multi-dimensional Spectral Graph Wavelet Transform
Authors: Sheikh Tawseef Ahmad Sheikh , Sheikh Neyaz A. Sheikh 
Published: December 2022

Abstract
In this paper, we introduce the two-dimensional spectral graph wavelet transform (SGWT) of discrete functions defined on Cartesian product graphs. We build this transform with the help of spectral decomposition of N1N2×N1N2 Laplacian matrix L of the Cartesian product graph G = G1□G2, where N1N2 is the number of vertices of the Cartesian product graph. We have established the inversion formula for SGWT for continuous scale parameter s. By sampling the scale parameter s at discrete values, we obtain discrete SGWT coeffients at different scales and vertices.We have found the frame bounds of the frame formed by the set of scaling and wavelet coeffients. Further, we have proved the localization result which holds for both normalized and non-normalized form of Laplacian. Towards the end we have given the implementation details of SGWT through an example to show how to calculate the graph wavelet coefficients.
Mathematics Subject Classification: 42C40; 42C15; 44A15; 44A35.
Difficult-to-treat axial spondyloarthritis: factors contributing to excessive biologic switching and burden of disease
Authors: Dua Devika , Gullick Nicola , Tonks Catherine , Young Keir , Blake Tim 
Published: December 2022

Abstract

Objectives
To identify factors that drive high biologic usage in a real-world clinical setting.
Methods
We collected retrospective data from all patients with axial spondyloarthritis who had received biologic therapy for their disease in our designated specialised clinic in a tertiary centre. Our outcome measure was ‘high biologic usage’ (defined as the use ≥ 3 biologic drugs/tsDMARDs and/or ≥ 2 biologic pathways targeted for therapy. We analysed patient age, sex, BMI, the concomitant presence of chronic widespread pain (CWP), HLA-B27 positivity, radiographic-SpA, extra-articular manifestations, time to initiate biologic therapy from diagnosis and disease activity measures (BASDAI, pain VAS and CRP) to identify predictors.
Results
Out of a total of 227 patients in our axSpA cohort, 166 (71% male, mean age 48 years) had received biologic therapy. Of these, 62 (27%) met the definition of high biologic usage. Our analysis identified four factors that were significantly associated with our outcome: HLA-B27 positivity (positive correlation), time to start biologic from diagnosis (negative correlation), concomitant chronic widespread pain (negative correlation) and aggregate BASDAI burden while on biologics (positive correlation).
Conclusion
There was a significant cohort of axial spondyloarthritis patients who met our criteria of ‘high biologic usage’. HLA-B27 positivity, the early requirement of biologics in the disease course and higher aggregate BASDAI burden were associated with greater biologic usage. A concomitant diagnosis of chronic widespread pain has the confounding effect of being associated with a higher BASDAI though lower biologic usage, exemplifying the impact this diagnosis has on clinical decision making. Key messages: Patients with axSpA receiving high-cost therapies form distinct clusters based on response to treatment, and the presence or absence of CWP. Concurrent CWP in axSpA can introduce cognitive bias when deciding on the need for change in therapy, especially given the subjective nature of assessments including BASDAI. AxSpA patients with CWP are likely to represent a distinct subtype of disease who display worse clinical outcomes and are likely to require alternative management strategies.
Effects of tree species and planting density on the total productivity of an agroforestry system
Authors: Teodoro Arthur Gabriel , Rodrigues Lucas Matheus , Rocha José Henrique , Santos Alessandro José , Backes Clarice , Lopes Luciana Christina , Ribon Adriana , Giongo Pedro 
Published: December 2022

Abstract

The agroforestry system consists of crop, forest, and pasture cultivation in combination, succession, or rotation, with the goal of increasing resource-use efficiency and, consequently, productivity. This system is an important strategy to recover degraded land. Our goal with this study was to assess the effects of the spacing and stand density of three Eucalyptus species on the total productivity of an agroforest system. For this purpose, an agroforest was planted in a degraded pasture in the central-eastern region of Brazil. The system consisted of three Eucalyptus species alongside maize and Crotalaria juncea in the first year, maize and grass-to-silage production in the second year, and pasture during the third and fourth years. The increase in tree density led to greater wood production; however, it decreased the productivity of the other system compounds, indicating that the prioritization of one compound decreased the productivity of the others. Despite this negative correlation between tree growth and the growth of the other compounds, the most productive treatment (simple rows of E. urophylla) during the four years after the system implantation was 3 Mg ha− 1 of maize, 15.6 Mg ha− 1 of Crotalaria juncea for soil enhancement, 6.2 Mg ha− 1 of silage (maize with grass), 13.8 Mg ha− 1 of pasture, and 180 m3 ha− 1 of wood.
When synthetic biology fails: a modular framework for predicting genetic stability in engineered cell populations
Authors: Ingram Duncan , Stan Guy-Bart 
Published: December 2022

Abstract
Predicting the dynamics of mutation spread in engineered cell populations is a sought- after goal in synthetic biology. Until now, models that capture these processes have been lacking, either by failing to account for the diversity of mutation types, or by failing to link the growth rate of a cell to the consumption of shared cellular resources by synthetic constructs. In this study we address these shortcomings by building a novel mutation-aware modelling framework of cell growth in a turbidostat. Our framework allows users to input essential design elements of their synthetic constructs so as to predict the time evolution of different mutation phenotypes and protein production dynamics. Its structure allows quick mutation-based analysis of any construct design, from single-gene constructs to multi-gene devices with regulatory elements. We show how our framework can generate new insights into industrial applications, such as how the design of synthetic constructs impacts long-term protein yield and genetic shelf-life. Our framework also uncovers new mutation-driven design paradigms for synthetic gene regulatory networks, such as how mutations can temporarily increase the bistability of toggle switches, or how repressilators can be resistant to single points of failure.
Identification of the anoikis-related prognostic gene signature in pancreatic adenocarcinoma
Authors: Chen Wei , Xu Zeyan , Jiang Jingjing , Chen Hong , Shi Ruihua 
Published: December 2022

Abstract
Pancreatic adenocarcinoma (PAAD) remains a tumor with high malignancy and poor prognosis. Anoikis can regulate tumor cell invasion and metastasis, which in turn leads to poor prognosis for cancer patients. However, the role of anoikis-related genes (ARGs) in PAAD remains unclear. In our study, we performed a comprehensive bioinformatics analysis to construct a prognostic gene model. Correlations between ARGs and tumor immune infiltration, tumor mutation burden and microsatellite instability were assessed using Spearman correlation analysis. A total of 23 ARGs were upregulated in PAAD. Functional enrichment analysis revealed that these 23 ARGs were mainly involved in proteoglycans in cancer, regulation of anoikis, lipid and atherosclerosis, focal adhesion, and regulation of apoptotic Prognostic analysis showed that patients with PAAD with high expression of PTK2, ITGB1, EGFR, CASP8, BCL2L1, and CASP3 had a low survival rate. The prognostic ARGs model constructed using the above six prognostic genes was constructed to predict the overall survival of PAAD patients. There was a significant correlation between prognostic ARGs and immune cell infiltration and tumor mutation burden, while there was no correlation with microsatellite instability. Meanwhile, knockdown of BCL2L1 expression could inhibit the proliferation of pancreatic cancer cells. In conclusion, we performed a comprehensive bioinformatics analysis to identify PAAD patients containing six genes (PTK2, ITGB1, EGFR, CASP8, BCL2L1, and CASP3). Further studies are needed to validate our findings.
Evaluating the characteristics of Myocardial Work by Two-Dimensional Echocardiography during Pre-eclampsia Pregnancy
Authors: Piao Shun-Fu , Cong Juan , Li Rong , Song Guang-Hui , Li Yong , Xu Lin 
Published: December 2022

Abstract
This study aimed to analyze the changes in myocardial work (MyW) properties and the correlation of MyW with cardiovascular indices during the pre-eclampsia (PE) pregnancy. Standard two-dimensional and speckle-tracking echocardiography were sequentially performed on 77 women with PE and 89 with normal pregnancy. Four components of MyW: global myocardial work index (GWI), constructive work (GCW), wasted work (GWW), and work efficiency (GWE) were measured. The significant increased GWI, GCW and GWW with decreased GWE were observed, while GWW elevated more than GCW with consequently resulting the decline in GWE in PE cases. Further, there was a various relationship between MyW elements and LV morphological as well as functional parameters. Those findings of MyW in the patients with PE may indicate the changes in cardiac contraction and myocardial metabolism as well as the imbalance between them during PE gestation, which not detected by left ventricular ejection fraction and strain alone.
Protocol of identical exercise programs with and without specific breathing techniques for the treatment of chronic low back pain: randomized feasibility trial with two-month follow-up.
Authors: Mikkonen Jani , Luomajoki Hannu , Airaksinen Olavi , Goubert Liesbet , Leinonen Ville 
Published: December 2022

Abstract
Background
Chronic low back pain (CLBP) is a leading cause of disability globally. Exercise therapies are one of the commonly prescribed treatment options for CLBP. The specific exercise therapies for CLBP most commonly target movement dysfunction, but seldom brain-based pain modulation. Exercise therapies with specific breathing techniques (SBTs) have been shown to influence and enhance brain-based structural and functional pain modulation.
Aims and objectives
To assess the feasibility of the SBTs protocol, eligibility criteria, randomization, and dropout rates. To quantify the changes in patient outcome measures and choose the most relevant measure for larger-scale study. To quantify self-adherence levels to home exercise and monitor and record possible pain medication and other treatment modality usage, and adverse events during exercise.
Design
A parallel randomised analyst-blinded feasibility trial with two-month follow-up.
Outcome measures
Feasibility related to aims and objectives. Multiple pain- and health-related patient-reported outcome measures of pain intensity, disability, central sensitization, anxiety, kinesiophobia, catastrophising, self-efficacy, sleep quality, quality of life, and health and well-being status. Exercise adherence, pain medication and other treatment modality usage, and possible adverse events related to exercises will be monitored and recorded.
Methods
Thirty participants will be randomized to movement control exercise with SBTs (experimental group) or movement control exercise without SBTs (control group) with an allocation ratio of 1:1.
Discussion
SBTs are a simple, free, and safe addition to exercise that may influence clinical outcomes. The clinical difference in effectiveness between practically identical exercise programs in uniform study settings with or without SBTs has not been studied before.