bluuebunny/crossref_metadata_2025_split huggingface dataset:
Satellite retrieved stubble-burning activities in north-western India in 2021: Contribution to air pollution in Delhi
Authors: Govardhan Gaurav , Ambulkar Rupal , Kulkarni Santosh , Vishnoi Ashok , Yadav Praful , Choudhury B. Abida , Khare Manoj , Ghude Sachin D. 
Published: March 2022

Abstract
Stubble-burning in northern India is an important source of atmospheric particulate matter (PM) and trace gases, which significantly impact local and regional climate, in addition to causing severe health risks. Scientific research on assessing the impact of these burnings on the air quality over Delhi is still relatively sparse. The present study analyzes the satellite-retrieved stubble-burning activities in the year 2021, using the MODIS active fire count data for Punjab and Haryana, and assesses the contribution of CO and PM2.5 from such biomass-burning activities to the pollution load in Delhi. The analysis suggests that the satellite-retrieved fire counts in Punjab and Haryana were the highest among the last five years (2016–2021). Further, we note that the stubble-burning fires in the year 2021 are delayed by ~ 1 week compared to that in the year 2016. To quantify the contribution of the fires to the air pollution in Delhi, we use tagged tracers for CO and PM2.5 emissions from fire emissions in the regional air quality forecasting system. The modeling framework suggests a maximum daily mean contribution of the stubble-burning fires to the air pollution in Delhi in the months of October-November 2021 to be around 30–35%. The quantification of this contribution is critical from the crop-residue and air-quality management perspective for policymakers in the source and the receptors regions, respectively.
Acidic culture medium enhances secretion of myoglobin and GDF-15 in MCF-7 breast cancer cells– multiplex assay data
Authors: Worsley Catherine Mary , Veale Rob B , Mayne Elizabeth S 
Published: March 2022

Abstract
Metastatic breast cancer is one of the leading causes of cancer mortality worldwide. While many therapeutic strategies try to control and combat this disease, a better understanding of cellular communication within the acidic tumour microenvironment is needed to improve treatment success. Here we characterized the secretory profile of MCF-7 breast cancer cells in medium of physiological pH, and compared it to those cells treated with medium of 6.5 and 3.2. MCF-7 cells secreted IP-10, VEGF, EGF, FGF, G-CSF, GDF-15, and myoglobin at baseline. When treated with acidic medium, MCF-7 cells downregulated secretion of many of these factors, although myoglobin and GDF-15 were significantly increased at pH 6.5 (1hr) (p < 0.0001). This may provide a survival advantage to the tumour cells at slightly acidic pH. Further studies investigating the effects of acidosis on breast carcinoma cells are needed to understand both their autocrine and paracrine signaling functions in the tumour microenvironment.
The Rice Blast Resistance Gene Pid Family Has Been Strictly Diverged Into Indica And Japonica Subspecies
Authors: Chai Ruipeng , Wang Jinyan , Wang Xing , Wen Jianqiang , Liang Zhijian , Ye Xuemei , Zhang Yaling , Yao Yongxiang , Zhang Jianfu , Zhang Yihua , Wang Ling , Pan Qinghua 
Published: March 2022

Abstract
Background: Rice blast (causative agent the fungus Pyricularia oryzae) represents a major constraint over the productivity of one of the world’s most important staple foods. Genes encoding resistance have been identified in both the indica and japonica subspecies genepools and combining these within new cultivars represents a rational means of combating the pathogen.Results: In this research, a deeper allele mining was carried out on Pid-2, Pid-3, and Pid-4 by each of comprehensive FNP marker set in the three panels consisting of 70 indica and 58 japonica cultivars. Within Pid-2, three functional and one non-functional alleles were identified; the former were only identified in indica type entries. At Pid-3, four functional and one non-functional alleles were identified, and once again, all of the formers were present in indica type entries. However, the pattern of variation at Pid-4 was rather different: here, the five functional alleles uncovered were dispersed across the japonica type germplasm. Among all the 12 candidate functional alleles, both Pid2-ZS and Pid3-ZS were predominant. Furthermore, the resistance functions of both Pid2-ZS and Pid3-ZS were assured by transformation test. Conclusions: Profiting from merits of three comprehensive FNP marker sets, the study has validated that all three members of the Pid family have been strictly diverged into indica and japonica subspecies: Pid-2 and Pid-3 were defined as indica type resistance genes, and Pid-4 as japonica one. Rather limited genotypes of the Pid family have been effective in both indica and japonica rice groups, of which Pid2-ZS+Pid3-ZS has been central to the Chinese rice population.
Structure-Based Virtual Screening, Molecular Docking, Molecular Dynamics simulation of VEGF inhibitors for the clinical treatment of Ovarian Cancer
Authors: Mukherjee Sourav , Abdalla Mohnad , Yadav Manasi , Madhavi Maddala , Bhrdwaj Anushka , Khandelwal Ravina , Prajapati Leena , Panicker Aravind , Chaudhary Aashish , Al-Brakati Ashraf , Hussain Tajamul , Nayarisseri Anuraj , Singh Sanjeev Kumar 
Published: March 2022

Abstract
Vascular Endothelial Growth Factor (VEGF) and its receptor play an important role both in physiologic and pathologic angiogenesis, which is identified in ovarian cancer progression and metastasis development. The aim of the present investigation is to identify a potential Vascular Endothelial Growth Factor inhibitor which is playing a crucial role in stimulating the immunosuppressive microenvironment in tumour cells of the ovary and to examine for an effectiveness of identified inhibitor for the treatment of ovarian cancer using various in-silico approaches. 12 established VEGF inhibitors were collected from various literature. The compound AEE788 displays the great affinity towards the target protein as a result of docking study. AEE788 was further used for structure-based virtual screening in order to obtain a more structurally similar compound with high affinity. Among the 80 Virtual screened compounds, CID 88265020, explicates much better affinity than established compound AEE788. Based on Molecular Dynamics Simulation, pharmacophore and comparative toxicity analysis of both the best-established compound and the best virtual screened compound displayed a trivial variation in associated properties. The virtual screened compound CID 88265020 have a high affinity with the lowest re-rank score, and holds a huge potential to inhibit the VGFR and can be implemented for prospective future investigations in Ovarian Cancer.
Platelet is the early predictor of bronchopulmonary dysplasia in very premature infants: an observational cohort study
Authors: Wang Xiaoling , Ma Yan , Wang Shenghui , Dong Wenbin , Lei Xiaoping 
Published: March 2022

Abstract
Background: A previous study showed that the lungs are involved in the biogenesis of platelets (PLTs). Thus, the present study aimed to investigate the association between bronchopulmonary dysplasia (BPD), a chronic lung disease, and PLT parameters in very premature infants.Methods: The study subjects were premature infants with a gestational age of ≤ 30 weeks and birth weight of ≤1500 g in a preterm birth cohort study recruited between January 1, 2015, and August 31, 2019. BPD was defined as the need for oxygen supplementation more than 28 days after birth. The PLT count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) level were compared between BPD and non-BPD infants. A generalized estimating equation model was used to adjust for confounding factors. A forward stepwise logistic regression model was used to calculate the adjusted odds ratio (OR) for thrombocytopenia in the BPD group. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive value of PLT count combined with gestational age (GA) and birth weight (BW) for BPD.Results: The final study subjects were 134 very premature infants, namely, 64 infants with BPD and 70 infants without BPD. The BPD infants had lower PLT counts (F=4.44, P=0.03) and PCT levels (F=12.54, P=0.00) than the non-BPD infants. However, the MPV (F=14.25, P=0.00) and PDW (F=15.04, P=0.00) were higher in the BPD group. After adjusting for potential confounding factors, the BPD infants had a higher risk of thrombocytopenia than the non-BPD infants (adjusted aOR 2.88, 95% CI 1.01-8.15), and the risk of BPD was increased in very premature infants with a PLT count ≤ 177*109/L (OR 4.74, 95% CI 1.93-11.62) at the end of the second week. In the multivariate predictive model, it was showed that the AUC area (0.85), sensitivity (0.88), specificity (0.70) and Youden index (0.58) are improved using PLT counts ≤ 177*109/L combined with GA and BW.Conclusions: Abnormal PLT parameters were observed in BPD infants, and a PLT count ≤ 177*109/L was a potential risk factor for the development of BPD in very premature infants.
The use of new technological processes and their impact on the assessment of energy efficiency measures in the region (on the example of reducing the negative environmental consequences of snow disposal in Russian cities)
Authors: Полетаев И.Ю. 
Published: March 2022

Проблема повышения эффективности использования ископаемых видов топлива для большинства стран мира является ключевой и напрямую связана со снижением объема выбросов парниковых газов в результате антропогенной деятельности. В данной статье показана необходимость анализа как краткосрочных, так и перспективных затрат при планировании мероприятий по внедрению новых технологий в условиях всеобщего энергетического кризиса, изменения структуры мирового энергетического рынка на фоне угрозы экологической катастрофы в связи с глобальным потеплением климата планеты.
The problem of increasing the efficiency of the use of fossil fuels for most countries of the world is a key one and is directly related to the reduction of greenhouse gas emissions as a result of anthropogenic activities. This article shows the need to analyze both short-term and long-term costs when planning measures for the introduction of new technologies in the conditions of a general energy crisis, changes in the structure of the world energy market against the threat of environmental catastrophe due to global warming of the planet's climate.
Assessment of the main parameters of the intellectual potential of the science city - Кorolev in the concept of its safe development
Authors: Сафронова Е.С. , Суглобов А.Е. 
Published: March 2022

В статье рассмотрен один из наукоградов - г. Королев, приведены характеристики его социально-экономического развития, рассмотрены элементы созданной инновационной инфраструктуры. Необходимость развития инновационной инфраструктуры и поддержки малого и среднего бизнеса для наукоградов обусловлена необходимостью технического перевооружения производства и стендовой базы, трансформации избыточной инфраструктуры градообразующих предприятий и организаций; развития эффективной кооперации востребованного инновационного малого и среднего бизнеса с крупными градообразующими предприятиями, привлечения новых малых предприятий в город. Рассматривая интеллектуальный потенциал, как способность осваивать и генерировать инновации, подчеркнута значимость воспроизводства кадрового потенциала высококвалифицированных рабочих и специалистов, закрепления молодых учёных и специалистов в научных организациях города, вовлечения детей в инновационную деятельность с помощью новых инновационных структур - кванториумов, популяризации востребованных градообразующими предприятиями рабочих профессий.
The article considers one of the science cities - Korolev, presents the hackterstics of its socio-economic development, considers the elements of the created innovative infrastructure. The need to develop innovative infrastructure and support small and medium-sized businesses for science is due to the need for technical re-equipment of production and the bench base, transformation from the everyday infrastructure of city-forming enterprises and organizations; development of effective cooperation of demanded innovative small and medium-sized businesses with large city-forming enterprises, attracting new small enterprises to the city. Considering the intellectual potential as the ability to master and generate innovation, the importance of reproducing the human resources potential of highly qualified workers and specialists, consolidating young scientists and specialists in scientific organizations of the city, involving children in innovative activities with the help of new innovative structures - quantorium, popularizing the professions demanded by city-forming enterprises.
Monitoring of the sustainable development of a territory
Authors: Чувашова М.Н. 
Published: March 2022

В статье предлагаются рекомендации по мониторингу устойчивого развития территории для органов власти. Основная цель предлагаемого мониторинга связана с проведением исследований по социально-экономическому и экологическому развитию и планированию территорий с целью достижения устойчивого развития и повышения межрегиональной и внутрирегиональной пространственной связанности. Предложен алгоритм государственного мониторинга устойчивого развития территории. Результаты мониторинга могут быть использованы региональными властями для формулирования положений по достижению устойчивого развития территории в рамках формирования Стратегии социально-экономического развития региона.
The paper proposes a methodology for the formation of monitoring of sustainable development of a territory. The main goal of the proposed methodology is connected with conducting research on socio-economic and environmental development and planning of territories in order to achieve sustainable development and increase inter-regional and intra-regional connectivity of territories. The algorithm for state monitoring of the sustainable development of a territory is proposed. The monitoring results can be used by regional authorities to formulate provisions for achieving the sustainable development of a territory within the framework of formation the Strategy for the socio-economic development of a region.
Formation of a region's portfolio of investment projects
Authors: Ващенко Т.В. , Восканян Р.О. 
Published: March 2022

Разработка и последовательная реализация инвестиционной стратегии региона выступает основой макроэкономической стабильности и повышает его инвестиционную привлекательность. В настоящей статье авторами предлагается алгоритм формирования портфеля инвестиционных проектов региона посредством ранжирования на две категории: проекты, приносящие высокий доход инвесторам за счет генерируемого будущего свободного денежного потока и социально-значимые проекты, не генерирующие непосредственно достаточного денежного потока, но создающие необходимые условия для формирования высокого уровня инвестиционного климата и деловой среды. Определение критериальной группы инвестиционного проектов позволяет в дальнейшем сформировать портфель, определяющий стратегическое развитие региона в области инвестиционных решений.
The development and consistent implementation of the region's investment strategy is the basis of macroeconomic stability and magnification of investment attractiveness. In this article, the authors have proposed an algorithm for forming a region's investment projects portfolio by ranking them into two categories. Projects that bring high income to investors due to the generated future free cash flow and socially significant projects that do not directly generate sufficient cash flow but create the necessary conditions for forming a high level of investment climate and business environment. The definition of the criterion group of investment projects makes it possible to develop further a portfolio that determines the region's strategic development in the field of investment decisions.
Integration of the regional economies of the people's Republic of China and the Russian Federation under the imperatives of accelerating the global energy transition
Authors: Филобокова Л.Ю. 
Published: March 2022

Ускорение мирового энергетического перехода обусловлено императивами обеспечения устойчивого социально-экономического развития, в условиях которого экологическая детерминанта приобретает особое значение и ставит на повестку получение синергетического эффекта от взаимодействия энергетической эффективности, децентрализации, диджитализации и декарбонизации. Решение таких задач предстоит обеспечить, прежде всего, на региональном уровне, в том числе и за счет интегрирования экономик КНР и РФ. Выдвигается и защищается положение о том, что двусторонняя интеграция региональных экономик КНР и РФ, в условиях ускоренного энергетического перехода, сопровождаемого повышенными рисками и высокой степенью неопределенности, способна обеспечить странам приток экономических выгод, решение ряда экологических и социальных проблем.
The acceleration of the global energy transition is due to the imperatives of ensuring sustainable socio-economic development, in which the environmental determinant is of particular importance and puts on the agenda the receipt of a synergistic effect from the interaction of energy efficiency, decentralization, digitalization and decarbonization. The solution of such tasks will have to be provided, first of all, at the regional level, including through the integration of the economies of the PRC and the Russian Federation. The position is put forward and defended that the bilateral integration of the regional economies of the PRC and the Russian Federation, in the conditions of an accelerated energy transition, accompanied by increased risks and a high degree of uncertainty, can provide countries with an influx of economic benefits, solving a number of environmental and social problems.
Assessment of innovative activities of small enterprises when deciding on the allocation of state support in the digital economy
Authors: Зайцев И.А. 
Published: March 2022

В статье рассмотрены рекомендации Правительства и правительственных структур по переходу малых предприятий народного хозяйства России к цифровой экономике. Продемонстрирована необходимость выделять государственную поддержку для обеспечения успешного перехода предприятий к работе с использований современных цифровых технологий, а также с применением отвечающих современным требованиям организационным практикам и управленческим методам. В статье рассмотрена методика оценки инновационной деятельности малого предприятия, результаты оценки по которой учитываются при принятии решения о выделении государственной финансовой поддержки.
The article discusses the recommendations of the Government and government agencies on the transition of small enterprises of the national economy of Russia to the digital economy. The need to allocate government support to ensure a successful transition of enterprises to work using modern digital technologies, as well as using organizational practices and management methods that meet modern requirements, is demonstrated. The article discusses the methodology for assessing the innovative activity of a small enterprise, the results of which are taken into account when deciding on the allocation of state financial support.
Methodological support for assessment of the spatial potential of urban agglomerations import substitution
Authors: Мачин К.А. 
Published: March 2022

Стагнация процессов глобализации в современной агломерационной экономике России позволяет искать новые стратегии развития региональных экономических систем. Процессы импортозамещения способствуют поиску потенциальных направлений развития торгово-производственной сферы агломераций. Оценка потенциала импортозамещения агломерации может осуществляться на основе эконометрического моделирования структуры импорта региональной территориальной экономической системы с выделением индивидуальных фиксированных эффектов потенциальных импортозамещающих товаров. Индивидуальные эффекты, характеризующие особенности спроса и потребления конкретного товара, позволяют оценить степень потребности в нем. Методический комплекс предлагаемый авторами работы позволяет провести количественную и номенклатурную оценку потенциала импортозамещения вплоть до четырехзначной номенклатуры ТН ВЭД.
The stagnation of globalization processes in the modern agglomeration economy of Russia makes it possible to search for new strategies to develop regional economic systems. Import substitution processes contribute to the search for potential directions for the development of the trade and production sphere of agglomerations. The assessment of the agglomeration potential for import substitution can be carried out on the basis of econometric modeling of the import structure of the regional territorial economic system with the allocation of individual fixed effects of potential import-substituting goods. Individual effects characterizing the features of demand and consumption of a particular product allow us to assess the degree of need for it. The methodological complex proposed by the authors of the work allows to make a quantitative and nomenclative assessment of the import substitution potential up to a four-digit nomenclature of Customs Commodity Code
Analysis of uncertainty and error of results in measurement of physical and mechanical parameters of materials
Authors: Фролов С.В. 
Published: March 2022

В статье изложен анализ оценки результатов измерений физико-механических параметров металлопродукции (прямые однократные измерения твердости и косвенные однократные измерения предела прочности) на основе расчетов границ погрешности и расширенной неопределенности в соответствии с требованиями национальных и международных стандартов. Приведены количественные расчеты степени увеличения границ расширенной неопределенности результата косвенных измерений предела прочности при учете коэффициентов чувствительности, что важно при оценке соответствия продукции установленным требованиям.
The article presents the analysis of the measurement results of physical and mechanical parameters of metal products (direct single hardness measurements and indirect single strength measurements) based on calculations of error limits and extended uncertainty in accordance with the requirements of national and international standards. Quantitative calculations of the extent of increased limits of extended uncertainty of the result of indirect measurements of ultimate strength are given taking into account sensitivity factors, which is important when assessing product compliance with established requirements.
Multiple sun-synchronous orbits for full coverage of the Earth
Authors: Виноградов Д.Ю. 
Published: March 2022

В данной статье произведена систематизация и развитие материалов, изложенных в [1], по проектированию кратных солнечно-синхронных орбит полного покрытия Земли. Разработан алгоритм формирования каталога орбитальных структур космической системы в первом приближении на кратных околокруговых солнечно-синхронных орбитах. Приведён фрагмент каталога орбит для конкретных исходных данных в качестве примера.
In this article the systematization and development of the materials described in [1] on the design of multiple sun-synchronous orbits of the full coverage of the Earth is carried out. An algorithm for forming a catalog of satellite constellation in the first approximation on multiple near-circular sun-synchronous orbits is developed. A fragment of the orbit catalog for specific source data is given as an example.