bluuebunny/crossref_metadata_2025_split huggingface dataset:
GENE POLYMORPHISM AMONG RESIDENTS OF TERNOPIL REGION AFFLICTED WITH ESSENTIAL ARTERIAL HYPERTENSION
Authors: Hnizdiukh R.V. , Shmanko V.V. 
Published: January 2022

Relevance. Dissensions in genotype distribution may substantively vary among different ethnic groups; that is why association of particular polymorphous markers with arterial hypertension (AH) development not always matches among distinct populations, which makes researches significant for every ethnic and population group.
Objective is to study prevalence of polymorphism of A1166C-gene of angiotensin II receptor of the first type and T786C-promoter of endothelial NO-synthase gene among patients with arterial hypertension, residents of Ternopil region.
Material and methods. We have examined 86 patients with arterial hypertension who were treated and examined in the therapeutic department of the Central District Hospital in Kozova, aged from 45 to 76 years. The control group consisted of 30 healthy individuals. Genetic typing of endothelial NOS genes and angiotensin II receptors (type 1) genes was performed by means of polymerase chain reaction with electrophoretic scheme of result detection.
Results. When analyzing the frequency distribution of genotypes of polymorphism A1166C of the angiotensin II receptor gene type 1, it was found that the proportion of CC genotype in patients with stage 3 hypertension was 61.1%, which is probably more than in the control group – 16.6% (χ² = 10, 0, p = 0.002). Among patients with stage 2 hypertension, the frequency of AA genotype A1166C polymorphism of the angiotensin II type 1 receptor gene was lower than in the control group (19.1% vs. 43.3%, χ² = 5.2, p = 0.02), and among patients with stage 3 hypertension, the number of individuals with the AA genotype was 11.1% versus 43.3% in the control group (χ² = 5.43, p = 0.02). Analysis of the T-786C polymorphism of the eNOS gene promoter revealed that in patients with stage 2 hypertension, the frequency of pathological CC genotype was higher than in the control group (38.3% vs. 16.6%, χ² = 4.09, p = 0.04 ), patients with stage 3 hypertension also had a greater number of carriers of the CC genotype than in the control group (44.4% vs. 16.6%, χ² = 4.4, p = 0.03).
Conclusions. Results of the research have shown that polymorphism of the type 1 angiotensin II receptors’ A1166C gene and of the eNOS gene T786C-promotor are associated with development of arterial hypertension.
Descubriendo la Estructura Organizacional
Authors: Norman Marilyn N. , Jordan Joy C. 
Published: January 2022

4-HS-FS101.3-Spn, a 3-page fact sheet by Marilyn N. Norman and Joy C. Jordan, is part of the 4-H 101 Fact Sheets series. It is the Spanish language version of 4-HS FS101.3/4H236: Discovering the Organizational Structure. It describes the national, state, county, and foundation roles in the 4-H organization. Published by the UF 4-H Youth Development Program, July 2009.
Regime Switching Mechanism during Energy Futures' Price Bubbles
Authors: Koy Ayben 
Published: January 2022

In the last twenty years, many huge ups and downs have been seen in not only oil prices but also in other spot and derivative' energy prices too. This study has two main purposes. The main purpose of the study is to detect bubbles and their beginning and ending dates in energy derivatives futures prices. Crude oil WTI, natural gas, and heating oil monthly prices are analyzed for the period beginning from 1990 to 2018. Following detecting bubbles, Markov Regime Switching Autoregressive (MSAR) models and Markov Regime Switching Vector Autoregressive (MSVAR) models are used to analyze the movement of the regime-switching mechanism between the bubble dates. The general evidence indicates that the switching mechanism during bubble periods has some mutual similarities as generally their direction is to regime 1 as recession with low/negative returns and high volatility. Following positive return periods in energy prices, mostly after the high return/high volatility periods, the market actors might face bubble collapses.
Deteksi Metichilin Resistance Staphylococcus Aureus (MRSA) Pada Peralatan Medis Yang Digunakan Di Ruang Rawat Inap RSUD Provinsi NTB
Authors: Pristianingrum Santy , Zainiati Baiq Lely , Muttaqin Zainul , Puspita Fergy Desy , Arman Rolly 
Published: January 2022

Methicillin resistant Staphylococcus aureus (MRSA) adalah jenis bakteri yang timbul karena resistensi terhadap antibiotik, di pusat layanan kesehatan penyebaran bakteri-bakteri yang mengalami resistensi tersebut dapat melalui sentuhan pasien dengan tenaga medis atau peralatan medis yang digunakan di fasilitas layanan kesehatan. Penelitian ini bertujuan untuk mendeteksi keberadaan MRSA, resistensinya terhadap antibiotik serta mendeteksi keberadaan MRSA SSCmec tipe III. Sampel dari diafragma stetoskop dan manset tensimeter di ruang rawat inap RSUD Provinsi NTB, diperiksa secara mikrobiologi dan secara molekuler menggunakan teknik PCR (Polimerase Chain Reaction) menggunakan primer SSCmec Tipe III. Selama bulan Januari hingga Februari 2018 didapatkan sebanyak 20 sampel swab diafragma stetoskop dan 18 swab manset tensimeter. Pengambilan sampel dilakukan pada akhir Januari hingga pertengahan Februari 2018. Hasil penelitian ditemukan sebanyak 2 isolat dari swab diafragma stetoskop (10%) dan 2 dari manset tensimeter (11.1%) terdeteksi sebagai MRSA. Dari empat isolate tersebut semuanya masih sensitive terhadap Vancomycin, tiga isolate resisten Clindamycin, Cefoxitin, dan Oxacilin, serta 1 isolat resisten Cefoxitin dan Oxacilin. Hasil pemeriksaan PCR pada 4 isolat MRSA menunjukkan tidak ditemukan MRSA SSCmec tipe III.
Analisis Mutu Pelayanan Terhadap Tingkat Kepuasan Pasien Di Laboratorium Rumah Sakit Umum Daerah Kota Mataram
Authors: Santoso Teguh , Fikri Zainal , Jiwantoro Yudha Anggit 
Published: January 2022

Rumah sakit merupakan salah satu bentuk sarana kesehatan, baik yang diselenggarakan oleh pemerintah maupun masyarakat yang berfungsi untuk melakukan upaya kesehatan dasar atau kesehatan rujukan dengan meningkatkan mutu pelayanan. Mutu pelayanan kesehatan merupakan faktor penting dalam keberhasilan suatu rumah sakit, dimana terdapat pelayanan laboratorium yang tidak dapat terpisahkan dengan rumah sakit. Pelayanan yang diberikan laboratorium sangat berpengaruh terhadap tingkat kepuasan pasien. Cara pengukuran tingkat kepuasan pasien menggunakan lima dimensi mutu pelayanan seperti, bukti fisik (tangible), kehandalan (reliabilty), ketanggapan (responsiveness), jaminan (assurance), dan empati (empathy). Mengetahui mutu pelayanan terhadap tingkat kepuasan pasien di laboratorium RSUD Kota Mataram. Jenis penelitian ini adalah survei analitik dengan rancangan cross sectional. Populasi dalam penelitian ini adalah pasien laboratorium RSUD Kota Mataram, sampel penelitian sebanyak 98 orang. Tekknik pengambilan sampel purposive sampling dengan kriteria sampel. Pengumpulan data menggunakan kuesioner tentang pengaruh mutu pelayanan terhadap tingkat kepuasan pasien. Analisis data dengan uji chi square. Hasil penelitian karakteristik responden berdasarkan lima dimensi mutu pelayanan, didapatkan hasil variabel mutu pelayanan: tangible baik (67,4%), tidak baik (32,6%), reliability baik (83,7%), tidak baik (16,3%), responsiveness baik (94,0%), tidak baik (6,0%), assurance baik (51,1%), tidak baik (48,9%), dan empathy baik (97,0%), tidak baik (3,0%). Variabel kepuasan pasien responden yang mengatakan puas sebesar (74,5%). Hasil penelitian menunjukkan p value (0.000). Ada pengaruh mutu pelayanan terhadap tingkat kepuasan pasien di laboratorium RSUD Kota Mataram.
Perubahan Status Gizi Balita Dengan Akupresur Selama Pemberian Makanan Tambahan (PMT) Pemulihan Pada Balita
Authors: Anggraeni Enggar , Palupi Mirthasari , Trisnagati Risma 
Published: January 2022

Background : Nutritional problems are still one of the problems faced by Indonesia. Malnutrition and micronutrient deficiencies are major nutritional problems facing Indonesia. Macro-nutrient deficiency occurs when the body lacks energy and protein, this is due to a gap between nutritional needs and nutrient intake so that it can cause a deficiency of micronutrients in the body which has an impact on malnutrition or malnutrition status. Inadequate nutrition is a condition of a lack of energy and protein intake, while malnutrition is a lack of energy and protein intake for a long period of time. Provision of Recovery Supplement (PMT Recovery) is a program aimed at overcoming the problem of malnutrition and malnutrition by improving nutritional status, fulfilling children's nutritional needs so that good nutritional status and condition are achieved according to the child's age. So that in this study the role of PMT is used in order to increase body weight and nutritional status of children. Objectives : The purpose of this study was to distinguish nutritional status during supplementation with supplementary food with acupressure. Methods : This research uses quantitative research type, with the research design used is Quasy Experiment with Pre and Post Test Control Group Design approach. The statistical test used was the Independent t-Test and Wilcoxon test. Results : The results of the study conducted on 3 - 16 July 2020 with a sample of 10 toddlers with acupressure, weight gain before and after PMT administration ranged from 0.2 to 0.4 kg, while the p value is 0.004 <0.05 then there are the difference between body weight before and after giving PMT. As for the Nutritional Status of the statistical test results obtained p value of 0.083 (> 0.05) which indicates that there is no difference between the nutritional status of children under five before and after giving PMT.
ASUHAN GIZI PADA IBU HAMIL DENGAN HIPEREMESIS GRAVIDARUM
Authors: Efrizal Wiwin 
Published: January 2022

Background : Hyperemesis gravidarum is a condition of nausea and vomiting that causes weight loss in pregnant women. Hyperemesis can cause malnutrition in the mother and affect the fetus and risk causing death. Purpose : The purpose of writing is to provide a comprehensive description of nutritional care for pregnant women with hyperemesis gravidarum using the literature review method. From the study, it is known the importance of proper nutritional care for mothers with hyperemesis gravidarum in the form of a cycle of assessment, nutritional diagnosis, intervention, monitoring and evaluation which are carried out continuously to overcome the problem of hyperemesis gravidarum in collaboration with the nutrition care team. Conclusion : The conclusion is that nutritional care with a comprehensive understanding of the problem of hyperemesis gravidarum in the form of cross-professions collaboration will improve the nutritional status of mothers.
RASIO SUKROSA DAN KARAGENAN TERHADAP KARAKTERISTIK FISIKO-KIMIA DAN SENSORI ES KRIM CEMPEDAK (ARTOCARPUS INTEGER)
Authors: Rahayuni Tri , Astina Astina , Fadly Dzul 
Published: January 2022

Background : Ice cream is a frozen food made through freezing and agitationPurpose : This study aimed to determine the effect of sucrose and carrageenan on the physical, chemical, and organoleptic properties of cempedak ice cream.Method : This study was a Randomized Block Design (RBD) with two factors, Carrageenan (0.3%, 0.4%, 0.5%) and Sucrose (9%, 12%, 15%).Results : The best level of carrageenan and sucrose was determined through the effectiveness index test method was 0.5% carrageenan and 15% sucrose. The best ice cream products were with chemical characteristics of 1.47% fat and 15.87% protein. In addition, there were physical characteristics, in the form of overrun (31.67%), melting speed (17.87 minutes), and sensory characteristics were ranging from moderate-like on the parameters of taste (3.37), texture (3.43), color (3,31), aroma (3,27), and liking (3,33). Conclusion : Thus, a right ratio of sucrose and carrageenan produces cempedak ice cream products with appropriate characteristics.Latar Belakang : Es krim adalah pangan beku yang melalui proses pembekuan dengan agitasi.Tujuan : Penelitian ini bertujuan untuk menentukan pengaruh sukrosa dan karagenan pada sifat fisik, kimia, dan organoleptik pada es krim buah cempedak.Metode : Penelitian ini merupakan Rancangan Acak Kelompok (RAK) dengan dua faktor yaitu Karagenan (0,3%, 0,4%, 0,5%) dan Sukrosa (9%, 12%, 15%).Hasil : Taraf karagenan dan sukrosa terbaik ditentukan melalui metode uji indeks efektivitas, yaitu karagenan 0,5% dan sukrosa 15%. Produk es krim terbaik tersebut memiliki karakteristik kimia, yaitu 1,47% lemak, dan 15,87% protein. Selain juga, memiliki karakteristik fisik, berupa overrun (31,67%), kecepatan leleh (17,87 menit), dan karakteristik sensoris berkisar agak suka hingga suka pada parameter rasa (3,37), tekstur (3,43), warna (3,31), aroma (3,27), dan kesukaan (3,33).Kesimpulan : Demikian, maka rasio tepat sukrosa dan karagenan menghasilkan produk es krim cempedak dengan karakteristik yang sesuai.
FAKTOR YANG MEMPENGARUHI SISA MAKANAN DAN BIAYA YANG TERBUANG PADA PASIEN SKIZOFRENIA RAWAT INAP
Authors: Fitriati Astri , Sofiyatin Reni , Suhaema Suhaema , Suranadi Luh 
Published: January 2022

Background : The success of a food maintenance system can be evaluated by observation of food waste that causes the cost to be wasted and will have an impact on the anggran used for the procurement of foodstuffs. The observations showed that in Mutiara Sukma Mental Hospital, there were still food waste that was not consumed by patients.Objective : This study aims to analyze "factors that affect food waste and its relationship to the cost of food waste".Method : The type of research is cross sectional with survey approach. Respondents to this study were 24 patients who underwent hospitalization from December 1 to 10, 2020. The food waste data was taken by observation using Comstock's visual method and compared with the price of the menu, patient assessment data on food taste was obtained by interview using questionnaires. The relationship between food waste and food waste costs was obtained by pearson correlation tests.Result : Average food waste in period 1 menu cycle of 9.07%, from the results of double logistic regeresi test there is no relation between food waste wit ofh age, gender and taste of food. The cost of food waste cost per patient per day is Rp. 2283.5,-Conclusion : Food waste correlated with the cost of food waste. Latar belakang : Keberhasilan suatu sitem penyelenggaraan makanan dapat dievaluasi dengan pengamatan sisa makanan yang menyebabkan adanya biaya yang terbuang secara sia-sia dan akan berdampak terhadap anggaran yang digunakan untuk pengadaan bahan makanan. Hasil observasi menunjukkan bahwa di Rumah Sakit Jiwa Mutiara Sukma masih ditemukan adanya sisa makanan yang tidk dikonsumsi oleh pasien.Tujuan : Penelitian ini bertujuan untuk menganalisis “ Faktor-faktor yang mempengaruhi sisa makanan dan hubungannnya dengan biaya sisa makanan”.Metode : Jenis penelitian adalah cross sectional. Responden sebanyak 24 pasien yang menjalani rawat inap di ruang pemulihan. Waktu penelitian 1-10 Desember 2020. Metode visual Comstock untuk pengukuran sisa makanan kemudian melihat biaya dari sisa dengan membandingkan dengan harga menu persajian. Analisis faktor yang mempengaruhi sisa dengan uji regresi logistk ganda dan melihat hubungan antara sisa makanan dan biaya sisa makanan diperoleh dengan uji korelasi pearson.Hasil : Rata-rata sisa makanan dalam periode 1 siklus menu sebesar 9.07%, tidak terdapat hubungan antara sisa makanan dengan umur, jenis kelamin dan cita rasa makanan. Biaya sisa makanan per pasien perhari sebesar Rp. 2283.5.Kesimpulan : Sisa makanan berkorelasi dengan biaya sisa makanan.
Strengthening the Capacity of Village Community Institutions through Village-Owned Enterprises in Sumbermulyo Village Bantul, Yogyakarta
Authors: Setiawan Hendy , Sulistyo Nur Wahyu 
Published: January 2022

The success of village-owned enterprises management cannot be separated from the quality of the performance and leadership of a village head. The more village-owned enterprises can develop rapidly, then there is the role and contribution of the Village Head as a catalyst for strengthening village community institutions. The purpose of this article is to provide an analysis related to how to strengthen village community institutions. Related to the focus of this research, namely the case of village-owned enterprises in Sumbermulyo Village, because the Village Head of Sumbermulyo has repeatedly been named the best Lurah in Yogyakarta, so whether this is in line with the development of village-owned enterprises in the village. The method used in this study uses a descriptive qualitative approach. Data collection techniques in this study used interview, observation, and documentation techniques. Processing research data using the stages of data presentation, verification, and drawing conclusions. The results of the study show that the management of the Sumbermulyo village-owned enterprises has not been able to run effectively and still encounters obstacles so that it is still far from being successful. This is related to strengthening the capacity of village governance which is still minimal so that further direction is needed. But on the other hand, independent innovations outside village-owned enterprises have also been found which are much more successful in their management, so that this can also be a means to form and revitalize village-owned enterprises so that their existence can be in line with village progress.
Estrategia de prevención de riesgos ocupacionales en estudiantes de enfermería de una institución pública en Popayán, Colombia.
Authors: González Rojas Tatiana , Tobar Sotelo Angela Maria 
Published: January 2022

Introducción. Según la OMS y la OIT, la seguridad y salud en el trabajo busca la promoción y mantenimiento de las condiciones de salud de los trabajadores desde un enfoque de bienestar físico, mental y social, mediante la prevención de enfermedades, de accidentes y el control de los riesgos. Sin embargo, la accidentalidad en el trabajo es un serio problema que está en aumento, cada año se presentan alrededor de 317 millones de accidentes de trabajo en el mundo. La tasa de accidentalidad de los estudiantes de enfermería es muy alta, donde los principales accidentes se presentan por pinchazos, salpicaduras, realización de prácticas inseguras como dejar objetos punzantes sobre las superficies o reencapsular jeringuillas. Considerando lo anterior, este estudio tuvo como objetivo desarrollar una estrategia tecnológica de prevención de riesgos en la seguridad y salud ocupacional de los aprendices del programa de enfermería de un Centro de Formación del SENA.
Materiales y métodos. Estudio cuantitativo – descriptivo, con 11 estudiantes del programa de enfermería que se encontraban en etapa lectiva y productiva. La encuesta final fue validada por jueces expertos y estuvo conformada por 30 preguntas cerradas que establecieron las características demográficas, el perfil relacionado con riesgos ocupacionales y antecedentes, y el perfil tecnológico de los participantes.
Resultados. Los resultados de este estudio concuerdan con la alta accidentalidad de los estudiantes de enfermería reportada en estudios similares, estas condiciones han sido relacionadas con la exposición a diferentes riesgos laborales derivados del ejercicio de las profesiones de la salud como la exposición a riesgos biológicos, químicos, ergonómicos o psicosociales. Es por lo anterior, que resaltan la necesidad de creación de estrategias para la gestión de los riesgos laborales identificados en los entornos, donde cobra vital importancia las acciones enfocadas a la capacitación en cuanto al cumplimiento de protocolos, el fomento del uso adecuado de Elementos de Protección Personal y seguimiento continuo a los trabajadores.
Conclusiones. Se sugiere la replicación de este estudio en otros territorios del país, con el fin de visibilizar las condiciones de seguridad y salud de los estudiantes de enfermería, la accidentalidad y las medidas de prevención y mitigación de los riesgos, que permitan la realización de intervenciones adecuadas, el diseño e implementación de acciones de seguridad y salud en el trabajo acorde con las necesidades de la población.
Palabras clave. Estudiantes de enfermería, Salud Ocupacional, Riesgos laborales, eSalud.
LncRNA TCONS_00145741 Knockdown Prevents Thrombin-Induced M1 Differentiation of Microglia in Intracerebral Hemorrhage by Enhancing the Interaction Between DUSP6 and JNK
Authors: Wu Lanxiang , Zhan Qingqing , Liu Pan , Zheng Heqing , Liu Mingxu , Min Jun , Xie Liang , Wu Wei 
Published: January 2022

Background: The differentiation of microglia from M1 to M2 exerts a pivotal role in the aggression of intracerebral hemorrhage (ICH), and long non-coding RNAs (lncRNAs) are associated with the differentiation of microglia. However, the underlying mechanism had not been fully clarified.Methods: The expression profile of lncRNAs in thrombin-induced primary microglia was analyzed by RNA sequencing. Under thrombin treatment, the effect of lncRNA TCONS_00145741 on the differentiation of microglia was determined by immunofluorescence staining, quantitative real-time PCR, and Western blot. The potential mechanism and related signaling pathways of TCONS_00145741 in the M1 and M2 differentiation of microglia in ICH were assessed by Gene Ontology analysis, flow cytometry, RNA pull-down, RNA Immunoprecipitation, and RNA fluorescence in situ hybridization followed by immunofluorescence analysis.Results: LncRNA TCONS_00145741 expression was elevated in the thrombin-induced primary microglia, and the interference with TCONS_00145741 restrained the M1 differentiation of microglia and facilitated the M2 differentiation under thrombin treatment. The interference with TCONS_00145741 restrained the activation of the JNK pathway in microglia under thrombin treatment and repressed the JNK phosphorylation levels by enhancing the interaction between DUSP6 and JNK. In vivo experiments further illustrated that the interference with TCONS_00145741 alleviated ICH.Conclusion: LncRNA TCONS_00145741 knockdown prevented thrombin-induced M1 differentiation of microglia in ICH by enhancing the interaction between DUSP6 and JNK. This study might provide a promising target for the clinical treatment of ICH.