bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomical and histological investigation of the pineal gland in the lake van fish (Alburnus tarichi (Güldenstädt, 1814))
Authors: Örği Elif , Oğuz Ahmet Regaib 
Published: March 2022

AbstractThe pineal gland and melatonin secreted from the gland regulate the biological clock and adaptation to seasonal changes, glucose balance, nutrition and locomotor activities. In this study, the pineal gland of the Lake Van fish was examined anatomically and histologically. The melatonin level secreted from the pineal gland was determined in fish plasma sampled from both lakes and streams during reproduction migration. The pineal gland in the Lake Van fish, as in other teleost fish, is located in the head, under the translucent pineal window, which does not contain many pigment cells. The gland consists of pineal vesicle and pineal stalk parts on the dorsal sac in the Lake Van fish. It was determined that the pineal gland showed good vascularity. The presence of pinealocytes and different types of cells in the pineal organ was determined histologically. Pinealocytes were intensely localized in the lumen of the pineal vesicle. The plasma melatonin level increased in fish passing from lake to stream for reproductive migration.
Impact of COVID‐19 on appendicitis presentations in children in Australia and New Zealand
Authors:   ANZSCRAFT Collaborative, Roberts Kiera 
Published: March 2022

AbstractBackgroundIn contrast to many countries, the prevalence of COVID‐19 in Australia and New Zealand has been low. We hypothesised, however, that a potential secondary effect of the COVID‐19 pandemic would be delayed presentation of paediatric appendicitis, with resultant higher rates of complicated appendicitis. This study was an initiative of the Australian and New Zealand Surgery in Children Registrars' Association for Trials collaborative, a trainee‐led research group based in Australia and New Zealand.MethodsA binational multicentre, retrospective review was undertaken of paediatric patients with appendicitis early in the COVID‐19 pandemic (20 March–30 April 2020), compared with previous years (2018, 2019). Primary outcomes were the duration of symptoms prior to presentation and the severity of disease.ResultsA total of 400 patients from six centres were included. Duration of symptoms prior to presentation, sepsis at presentation, complicated disease and presence of complications did not differ significantly between time periods. Duration of intravenous antibiotic treatment and overall antibiotic treatment were both significantly shorter during 2020 (2.4 days versus 3.5 in 2018 and 3.0 in 2019 [P = 0.0038] and 3.7 days versus 5.2 in 2018 and 4.6 in 2019 [P = 0.04], respectively). Management approach did not differ, with the majority of patients managed operatively.ConclusionsWe did not demonstrate any difference in duration of symptoms prior to presentation or other markers of disease severity early in the pandemic. Duration of antibiotic treatment was shorter during this period compared with previous years. Management of children with appendicitis, both simple and complicated, did not appear to change as a result of COVID‐19.
Meta‐analysis: analysis of mechanistic pathways in the treatment of non‐alcoholic steatohepatitis. Evidence from a Bayesian network meta‐analysis
Authors: Ng Cheng Han , Muthiah Mark D. , Xiao Jieling , Chin Yip Han , Lim Grace , Lim Wen Hui , Tay Phoebe , Tan Darren Jun Hao , Yong Jie Ning , Pan Xin‐Hui , Koh Jeffery Wei Heng , Chew Nicholas , Syn Nicholas , Tan Eunice , Huang Daniel Q. , Siddiqui Mohammad Shadab , Loomba Rohit , Sanyal Arun J. , Noureddin Mazen 
Published: March 2022

SummaryBackground and AimsNon‐alcoholic steatohepatitis (NASH) is the most common cause of liver disease. However, there is lack of comparison of efficacy between different NASH drug classes. We conducted a network meta‐analysis evaluating drug classes through comparing histological outcomes and targets of drugs.Approach and ResultsMedline, EMBASE and CENTRAL were searched for randomised controlled trials evaluating NASH drugs in biopsy‐proven NASH patients. Primary outcomes included NASH resolution without worsening of fibrosis, at least 2‐point reduction in Non‐alcoholic fatty liver disease Activity Score (NAS) without worsening of fibrosis and at least 1‐point reduction in fibrosis. Treatments were classified into inflammation, energy, bile acid and fibrosis modulators. The analysis was conducted with Bayesian network model and surface under the cumulative ranking curve (SUCRA) analysis. Among 49 included trials, treatments modulating energy (Risk ratio (RR): 1.92, Credible intervals (Crl): 1.59‐2.34) were most likely to achieve NASH resolution followed by treatments modulating fibrosis (RR 1.66, Crl: 0.65‐4.50), bile acids (RR: 1.37, Crl: 0.99‐1.92) and inflammation (RR: 1.00, Crl: 0.75‐1.33). Energy and bile acids modulation were effective in at least 2‐point NAS reduction without worsening of fibrosis (RR: 1.52, Crl 1.30‐1.77; RR: 1.69, Crl 1.41‐2.03) and at least 1‐point reduction in fibrosis (RR: 1.26, Crl:1.05‐1.49; RR: 1.54, Crl: 1.20‐1.97).ConclusionsThis network analysis demonstrates the relative superiority of drugs modulating energy pathways and bile acids in NASH treatment. This guides the development and selection of drugs for combination therapies.
The quantification of midwifery research: Limiting midwifery knowledge
Authors: Newnham Elizabeth , Rothman Barbara Katz 
Published: March 2022

AbstractAs two academics researching in the area of maternal health, we are increasingly concerned with what we see as a positivist turn in midwifery research. In this paper, we examine this idea of the quantification of midwifery research, using as an example the current esteem given to the systematic literature review, and its creep into other methodologies. We argue that the current favor toward quantitative research and expertise in midwifery academia risks the future of midwifery research by the lack of equal development of qualitative experts, diluting qualitative research rigor within the profession, and limiting the kinds of questions asked. We identify the similarity between the current prominence of quantitative research and medical dominance in midwifery and maintain that it is of vital importance to the profession (research and practice) that the proper attention, contemplation, and merit are given to qualitative research methods.
Ermin deficiency leads to compromised myelin, inflammatory milieu, and susceptibility to demyelinating insult
Authors: Ziaei Amin , Garcia‐Miralles Marta , Radulescu Carola I. , Sidik Harwin , Silvin Aymeric , Bae Han‐Gyu , Bonnard Carine , Yusof Nur Amirah Binte Mohammad , Ferrari Bardile Costanza , Tan Liang Juin , Ng Alvin Yu Jin , Tohari Sumanty , Dehghani Leila , Henry Lily , Yeo Xin Yi , Lee Sejin , Venkatesh Byrappa , Langley Sarah R. , Shaygannejad Vahid , Reversade Bruno , Jung Sangyong , Ginhoux Florent , Pouladi Mahmoud A. 
Published: March 2022

AbstractErmin is an actin‐binding protein found almost exclusively in the central nervous system (CNS) as a component of myelin sheaths. Although Ermin has been predicted to play a role in the formation and stability of myelin sheaths, this has not been directly examined in vivo. Here, we show that Ermin is essential for myelin sheath integrity and normal saltatory conduction. Loss of Ermin in mice caused de‐compacted and fragmented myelin sheaths and led to slower conduction along with progressive neurological deficits. RNA sequencing of the corpus callosum, the largest white matter structure in the CNS, pointed to inflammatory activation in aged Ermin‐deficient mice, which was corroborated by increased levels of microgliosis and astrogliosis. The inflammatory milieu and myelin abnormalities were further associated with increased susceptibility to immune‐mediated demyelination insult in Ermin knockout mice. Supporting a possible role of Ermin deficiency in inflammatory white matter disorders, a rare inactivating mutation in the ERMN gene was identified in multiple sclerosis patients. Our findings demonstrate a critical role for Ermin in maintaining myelin integrity. Given its near‐exclusive expression in myelinating oligodendrocytes, Ermin deficiency represents a compelling “inside‐out” model of inflammatory dysmyelination and may offer a new paradigm for the development of myelin stability‐targeted therapies.
Big data, computational social science, and other recent innovations in social network analysis
Authors: Tindall David , McLevey John , Koop‐Monteiro Yasmin , Graham Alexander 
Published: March 2022

AbstractWhile sociologists have studied social networks for about one hundred years, recent developments in data, technology, and methods of analysis provide opportunities for social network analysis (SNA) to play a prominent role in the new research world of big data and computational social science (CSS). In our review, we focus on four broad topics: (1) Collecting Social Network Data from the Web, (2) Non‐traditional and Bipartite/Multi‐mode Networks, including Discourse and Semantic Networks, and Social‐Ecological Networks, (3) Recent Developments in Statistical Inference for Networks, and (4) Ethics in Computational Network Research.
Featured Cover
Authors: Germain Dominique P. , Levade Thierry , Hachulla Eric , Knebelmann Bertrand , Lacombe Didier , Seguin Vanessa Leguy , Nguyen Karine , Noël Esther , Rabès Jean‐Pierre 
Published: March 2022

The cover image is based on the Review Challenging the traditional approach for interpreting genetic variants: Lessons from Fabry disease by Dominique P. Germain et al., https://doi.org/10.1111/cge.14102.image
Boardroom gender diversity and investment inefficiency: New evidence from the United Kingdom
Authors: Farooq Sanaullah , Gan Christopher , Nadeem Muhammad 
Published: March 2022

AbstractResearch Question/IssueMotivated by the recent regulatory reforms, in the forms of the UK Corporate Governance Code (UK CGC) in 2011 and the enaction of section 414C of the Companies Act 2006, to increase female representation on corporate boards, this study investigates the effect of boardroom gender diversity (BGD) on investment inefficiency (IE). These reforms were aimed at enhancing corporate governance by allowing a pool of female directors into directorship positions and bringing fresher and independent perspective of female directors, thus strengthening board monitoring and its internal control systems. This study therefore seeks to understand whether and how female directors align managers' and shareholders' interests by improving investment efficiency.FindingsUsing a sample of UK listed firms from 2005 to 2018, this study provides the first empirical evidence on the impact of BGD on IE. Consistent with our theoretical predictions, we find a negative and statistically significant association between BGD and IE. Furthermore, in a difference‐in‐differences analysis, we find a significant impact of UK CGC on the BGD‐IE relationship. We also identify three possible channels (board dynamics, stewardship effect, and information environment) through which BGD is likely to affect IE. Finally, we also document that the said relationship is more pronounced in firms with three or more female directors, which is consistent with critical mass theory, and that BGD mitigates concerns surrounding both the underinvestment and overinvestment decisions. Our main results are robust to endogeneity bias, alternative measures of BGD and IE, and controlling for potential bias with a two‐step investment estimation method.Policy ImplicationsOur findings have important implications for regulators, policy‐makers, and other corporate stakeholders. Most importantly, the recent policy initiatives on improving representation of female directors can strengthen board monitoring and could reduce inefficient investments.
An evaluation of the properties of denim dyed with sulphur dyeing by elimination of pre‐treatment processes
Authors: Mezarciöz Serin , Sirlibaş Serdal 
Published: March 2022

AbstractIn recent years, the low‐environmental impact technology has given rise to new types of treatment in the textile industry. From the environmental point of view, mainly the textile dyeing process constitutes a significant pollution problem due to the variety and complexity of chemicals employed. Denim has been identified with indigo dyestuff throughout history. However, the percentage of warp yarn woven with sulphur‐dyed denim (included in the denim group of products) has increased in recent years. The justification of this study is to create a new concept in denim fabric dyeing. Conventional denim fabric properties have been tried to be obtained with less process. A novel method with a less environmentally detrimental technique that limits the use of water, chemicals, and other resources has been developed to achieve traditional denim fabric qualities. The colour changes, tensile‐tear strength, skew movement, dimensional stability, and the rubbing fastness values of fabrics dyed using these methods were examined comparatively. According to the results, the properties of fabric treated with the developed dyeing method, are very similar to those of the standard dyed fabrics. The tensile and tear strength values of the fabrics dyed using the reduced process method increased. The dimensional change and movement values of the fabric dyed with the new technique are higher. Fabric dyed with the conventional method has the highest K/S value but the lowest L* value. The greatest ΔE value was seen in fabrics with stone+hypo washing. The rubbing fastness value of the fabric dyed with the reduced process method was better.
Impact of psychiatric comorbidities in psoriasis, hidradenitis suppurativa and atopic dermatitis: The importance of a psychodermatological approach
Authors: Iannone Michela , Janowska Agata , Panduri Salvatore , Morganti Riccardo , Davini Giulia , Romanelli Marco , Dini Valentina 
Published: March 2022

AbstractBackgroundThere is a strong interaction between the immunological and nervous system in the skin. Lesions that are physically disfiguring and chronically relapsing have a high impact on quality of life (QoL) and can result in the emergence of psychiatric disorders. The literature data confirm a higher prevalence of psychiatric disorders in patients with psoriasis, hidradenitis suppurativa (HS) and atopic dermatitis (AD), but such data are compromised by low‐quality evidence due to methodological heterogeneity.ObjectivesThe primary aim was to analyse the prevalence of psychiatric comorbidities in a group of psoriasis, AD and HS patients compared with a control group. The secondary aims were to evaluate the impact of psychiatric comorbidities on the disease development, severity, flare‐ups and QoL.MethodsA total of 59 cases and 64 controls were included.ResultsGeneralized anxiety disorder and depressive disorder with anxious distress were found to be risk factors for AD. Age, smoking and substance‐related disorder showed a specific association with HS. Major depressive disorder showed a specific association with dermatology life quality index (DLQI) and all the above disease flare‐ups.ConclusionsAtopic dermatitis, psoriasis and HS are associated with psychiatric disorders. A psychodermatological approach improves outcomes in terms of QoL, disease flare‐ups and long‐term management.
Omaveloxolone attenuates squamous cell carcinoma growth and disease severity in an Epidermolysis Bullosa mouse model
Authors: Cohen‐Nowak Adam J. , Cohen Alexa J. , Correia Emily D. , Portocarrero Carla P. , South Andrew P. , Nikbakht Neda 
Published: March 2022

AbstractPatients with epidermolysis bullosa (EB) are susceptible to development of squamous cell carcinomas (SCC) at sites of chronic inflammation and fibrosis. While triterpenoids such as RTA 408 (Omaveloxolone) have been shown to reduce inflammation and inhibit tumour growth in various cancer models, the utility of this class of drugs in the treatment of SCC has not been investigated. Given the dual anti‐inflammatory and anti‐neoplastic properties of triterpenoids, we hypothesized RTA 408 would be an effective treatment for SCCs that arise in the chronic inflammatory setting in EB. We tested the effects of topical RTA 408 on a mouse model of non‐Herlitz, junctional EB. RTA 408 significantly reduced phenotypic severity in the affected ears of Lamc2jeb mice. In cultures, RTA 408 reduced cell viability in EB‐associated SCC cell lines and normal human epidermal keratinocytes. When administered in vivo, RTA 408 inhibited SCC tumour growth in mice without cutaneous or systemic toxicity. These results suggest that RTA 408 can be a promising new therapy to reduce inflammation and inhibit SCC growth in patients with EB.
RETRACTED: Hybrid multi agent optimization for optimal battery storage using micro grid
Authors: Bacanin Nebojsa 
Published: March 2022

AbstractDue to rising of power demands and distributed renewable power saturation, determining optimal capability of the battery energy storage system (BESS) and demand response (DR) inside the microgrid (MG) is critical. To overcome these issues, research proposed in this manuscript employs a hybrid swarm intelligence approach that incorporates game theory. Both BESS and DR concepts are used in the hybrid method operation. The proposed method employs multi‐agent guiding particle swarm optimization (MAPS) and Halton sequence and social motivation strategy based on the grey wolf optimizer (HSGW). The HSGW method helps in minimizing power utilization and energy loss. The results show that, when compared with the traditional methodology, the proposed MAPS‐HSGW method provides the cost‐effective selection between the agents and also decreases the operational cost by about 7.5%. Moreover, it was discovered that the proposed MAPS‐HSGW method outperforms other techniques in terms of results’ quality and computational time metrics.
Guiding principles for integrating stakeholder‐based data into marine fisheries decision‐making with a focus on USA fisheries management
Authors: Murphy Robert , Downs Michael , Wolf Nathan , Harris Bradley P. 
Published: March 2022

AbstractThe propensity for fisheries management agencies in the United States to collect or request stakeholder‐based data has grown considerably in the last decade. While systems are in place for the review and use of biological data in management, there is far less structure to the integration of non‐economic social data. Here, we present a framework for characterizing the applicability of various forms of social data in regulatory processes, documents, and decisions. The social data landscape is presented as a simple framework for understanding the temporal, spatial, and impact scope of policy actions and how different kinds of social data can inform an array of action types and play important roles in management. We conclude with recommendations for practitioners and managers who seek to incorporate different types of stakeholder input into their processes and provide researchers with guidelines when weighing the trade‐offs of unique methodologies.
Basin‐scale approach needed for Yangtze River fisheries restoration
Authors: Jin Binsong , Winemiller Kirk O. , Ren Wenwei , Tickner Dave , Wei Xiaohua , Guo Li , Li Qin , Zhang Hui , Pompeu Paulo Santos , Goichot Marc , Wang Sikai , Shen Ruichang , Wu Xiaoping 
Published: March 2022

AbstractThe Yangtze River contains the highest fish diversity and most important inland fishery resources in China, but its biota and ecosystem services face an uncertain future. The river and its basin have undergone vast changes from centuries of human impacts, and fish stocks are in a particularly dire situation. A complete 10‐year moratorium on commercial fishing within the entire Yangtze River was implemented starting in January 2021. By itself, the ban on fishing will unlikely guarantee full recovery. We conclude that multiple human impacts to the basin and its fish stocks require multidisciplinary strategies implemented at the whole basin scale for effective conservation.
Design‐driven resilience and the limits of geographic critique
Authors: Cox Savannah , Grove Kevin , Barnett Allain 
Published: March 2022

AbstractIn April of 2019, the Rockefeller Foundation's ‘100 Resilient Cities’ (100RC) programme abruptly shuttered, surprising programme proponents and critics alike. In this paper, we explore why this happened, why some styles of geographic critique could not anticipate 100RC’s closure, and what this inability means for dominant strands of critical geographic analysis. To answer these questions, we bring literature on the biopolitics of resilience, technopolitics and Black geographies to bear on the case of Greater Miami resilience planning. We argue that answers to these questions revolve around the designerly roots of resilience thinking, whose distinct intellectual lineage conventional critical approaches have struggled to pick up on. We show how, on the one hand, design practices of synthesis in Greater Miami attempted to frame and instrumentalise Black histories of and experiences with racial and environmental violence as bounded knowledge that could improve the functioning of complex systems. On the other hand, synthesis created overflowings: opaque knowledges and experiences that resist the framing process and continue to mediate political battles over what resilience in Greater Miami practically becomes. Based on the case, we propose that an inductive style of critique that traces processes of framing and overflowing can help advance critical geographic analysis. As we illustrate in the paper, this mode of critique pays specific attention to the opaque, historically and contextually specific knowledges and experiences that refuse to be framed or synthesised, and work to counter‐frame dominant conceptions of resilience—critical and conventional alike.
Revitalization mechanism of specialty industries in the karst rocky desertification areas: From a perspective of the actor‐network theory
Authors: Ren Bimo , Xiong Kangning , Wang Qi 
Published: March 2022

AbstractDespite the considerable constraints of karst rocky desertification on the production and life of the locals and the regional economy, few studies have been conducted on areas with karst rocky desertification with the aim of exploring the balance between ecological governance and industrial development. In light of the promotion of featured advantageous industries to ecological governance and industrial development, this study aims to explore the mechanism of industrial revitalization in areas with karst rocky desertification to provide theoretical support for their industrial revitalization. Based on actor‐network theory, this paper presents a case study of Bashan village, a typical area in Guizhou province, China, with karst rocky desertification, to clarify the course of development of itsZanthoxylum bungeanumindustry and propose a mechanism for its revitalization. The findings identify the main actors of the revitalization of theZ. bungeanumindustry and reveal the driving forces behind it. Moreover, the study found that the industrial revitalization model is a bottom‐up process, which suggests strong endogenous dynamics. Through the revitalization of the featured industries, the results of the management of rocky desertification are transformed into economic output, which improved the livelihood of farmers and consolidated the effectiveness of management.