bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of artificial light at night in marine ecosystems—A review
Authors: Marangoni Laura F. B. , Davies Thomas , Smyth Tim , Rodríguez Airam , Hamann Mark , Duarte Cristian , Pendoley Kellie , Berge Jørgen , Maggi Elena , Levy Oren 
Published: May 2022

AbstractThe globally widespread adoption of Artificial Light at Night (ALAN) began in the mid‐20th century. Yet, it is only in the last decade that a renewed research focus has emerged into its impacts on ecological and biological processes in the marine environment that are guided by natural intensities, moon phase, natural light and dark cycles and daily light spectra alterations. The field has diversified rapidly from one restricted to impacts on a handful of vertebrates, to one in which impacts have been quantified across a broad array of marine and coastal habitats and species. Here, we review the current understanding of ALAN impacts in diverse marine ecosystems. The review presents the current state of knowledge across key marine and coastal ecosystems (sandy and rocky shores, coral reefs and pelagic) and taxa (birds and sea turtles), introducing how ALAN can mask seabird and sea turtle navigation, cause changes in animals predation patterns and failure of coral spawning synchronization, as well as inhibition of zooplankton Diel Vertical Migration. Mitigation measures are recommended, however, while strategies for mitigation were easily identified, barriers to implementation are poorly understood. Finally, we point out knowledge gaps that if addressed would aid in the prediction and mitigation of ALAN impacts in the marine realm.
Four decades of climatic fluctuations and fish recruitment stability across a marine‐freshwater gradient
Authors: Colombano Denise D. , Carlson Stephanie M. , Hobbs James A. , Ruhi Albert 
Published: May 2022

AbstractInvestigating the effects of climatic variability on biological diversity, productivity, and stability is key to understanding possible futures for ecosystems under accelerating climate change. A critical question for estuarine ecosystems is, how does climatic variability influence juvenile recruitment of different fish species and life histories that use estuaries as nurseries? Here we examined spatiotemporal abundance trends and environmental responses of 18 fish species that frequently spend the juvenile stage rearing in the San Francisco Estuary, CA, USA. First, we constructed multivariate autoregressive state‐space models using age‐0 fish abundance, freshwater flow (flow), and sea surface temperature data (SST) collected over four decades. Next, we calculated coefficients of variation (CV) to assess portfolio effects (1) within and among species, life histories (anadromous, marine opportunist, or estuarine dependent), and the whole community; and (2) within and among regions of the estuary. We found that species abundances varied over space and time (increasing, decreasing, or dynamically stable); and in 83% of cases, in response to environmental conditions (wet/dry, cool/warm periods). Anadromous species responded strongly to flow in the upper estuary, marine opportunist species responded to flow and/or SST in the lower estuary, and estuarine dependent species had diverse responses across the estuary. Overall, the whole community when considered across the entire estuary had the lowest CV, and life histories and species provided strong biological insurance to the portfolio (2.4‐ to 3.5‐fold increases in stability, respectively). Spatial insurance also increased stability, although to a lesser extent (up to 1.6‐fold increases). Our study advances the notion that fish recruitment stability in estuaries is controlled by biocomplexity—life history diversity and spatiotemporal variation in the environment. However, intensified drought and marine heatwaves may increase the risk of multiple consecutive recruitment failures by synchronizing species dynamics and trajectories via Moran effects, potentially diminishing estuarine nursery function.
Recent development on recovering bioactive peptides and phenolic compounds from under‐utilised by‐products during production of certain edible oil plants: current situation and future perspectives
Authors: Karami Zohreh , Akbari‐adergani Behrouz , Duangmal Kiattisak 
Published: May 2022

SummaryDuring the edible oil production process, massive amounts of by‐products are generated each year that are not efficiently utilised, posing economic and environmental challenges. Under‐utilised products derived from valuable oil‐plants such as oil‐extracted wheat germ, oil‐extracted moringa seed, oil‐extracted walnut and flaxseed meal will be increased, and new integration concepts will be required as soon as possible. These underutilised products can be rich sources of phenolic compounds and bioactive peptides with appropriate health‐promoting properties such as anti‐diabetic, antioxidant, anti‐hypertensive, anti‐inflammatory, anticancer and antibacterial properties, according to this review. The recovery of bioactive compounds from these by‐products can go a long way toward ensuring a sustainable food supply. Current challenges and requirements for recovering bioactive peptides and phenolic compounds from underutilised products derived from valuable oil‐plants as well as the relationship between their biological activity and structure are discussed in this study.
Effects of high‐pressure pretreatment on acid extraction of pectin from pomelo peel
Authors: Duan Hanying , Yan Xu , Azarakhsh Nima , Huang Xuesong , Wang Chao 
Published: May 2022

SummaryTo explore the effects of high‐pressure processing (HPP) pretreatment on pectin extraction from pomelo albedo, the extraction yield, and characteristics of pectin were compared with those obtained via traditional acid (A‐pectin) extraction. Three different pressures (300, 450, and 600 MPa) and holding times (0, 5, and 10 min) were applied to the fresh albedo, followed by acid extraction. The yield, degree of esterification (DE), galacturonic acid (GalA) content, Fourier transform‐infrared (FT‐IR) spectra, and rheological properties of pectin were investigated. By comparison with A‐pectin, the yield increased by more than two and four times at 300 MPa at holding times of 5 and 10 min, respectively. All extracted pectins were high methoxyl pectins (DE of 76.30–87.83%) with high GalA content (62.3–86.60%); however, there were significant decreases in DE and GalA content when pressure was increased to 600 MPa in comparison with A‐pectin. The pressure level and holding time significantly influenced the viscosity of pectin, and HPP‐pectin 300‐5, 450‐10, and 600‐0 exhibited a much higher viscosity than A‐pectin. Consequently, this study demonstrated that HPP pretreatment of fresh albedo can increase extraction yield and/or alter pectin characteristics for further industrial applications.
5‐Aminolevulinic acid has the potential to prevent bladder dysfunction in cyclophosphamide‐induced hemorrhagic cystitis
Authors: Kuno Takahira , Shimizu Takahiro , Kawada Chiaki , Kurabayashi Atsushi , Zou Suo , Mogawa Hiroki , Tsuda Masayuki , Saito Motoaki , Inoue Keiji 
Published: May 2022

ObjectivesTo investigate the effects of pretreatment with 5‐aminolevulinic acid hydrochloride combined with sodium ferrous citrate on bladder dysfunction in cyclophosphamide‐induced hemorrhagic cystitis in rats.MethodsMale Wistar rats (340–460 g) were pretreated with vehicle or with 5‐aminolevulinic acid hydrochloride combined with sodium ferrous citrate (100/157 or 300/471 mg/kg/day, po) once daily for 7 days before cystometry. Saline or cyclophosphamide (150 mg/kg, ip) was administered 2 days before cystometry. Cystometry was performed under urethane anesthesia (0.8 g/kg, ip) via a catheter inserted into the bladder. After cystometry, bladder tissues were collected to perform hematoxylin and eosin staining for pathological evaluation (neutrophil infiltration, edema, and bleeding scores), and for enzyme‐linked immunosorbent assay and real‐time polymerase chain reaction for investigating tissue levels of myeloperoxidase, and mRNA levels of haem oxygenase‐1 as a cytoprotective molecule.ResultsCompared to controls, cyclophosphamide induced a shorter intercontraction interval, lower bladder compliance, increased number of non‐voiding contractions, and increased pathological scores and myeloperoxidase expression in the bladder. Pretreatment with 5‐aminolevulinic acid hydrochloride combined with sodium ferrous citrate (300/471 mg/kg/day) significantly improved cyclophosphamide‐induced intercontraction interval shortening and increases in number of non‐voiding contractions and neutrophil infiltration/bleeding scores and enhanced haem oxygenase‐1 expression in the bladder. In addition, cyclophosphamide‐induced decreases in bladder compliance and increases in myeloperoxidase were not detected with 5‐aminolevulinic acid hydrochloride combined with sodium ferrous citrate pretreatment.ConclusionsPretreatment with 5‐aminolevulinic acid expects protective effects on bladder dysfunction in cyclophosphamide‐induced hemorrhagic cystitis by improving inflammatory changes in bladder tissues perhaps via up‐regulation of haem oxygenase‐1.
The metabolic characteristic of decidual immune cells and their unique properties in pregnancy loss*
Authors: Zhang Tao , Shen Hui‐Hui , Qin Xue‐Yun , Li Ming‐Qing 
Published: May 2022

AbstractMaternal tolerance to semi‐ or fully allograft conceptus is a prerequisite for the maintenance of pregnancy. Once this homeostasis is disrupted, it may result in pregnancy loss. As a potential approach to prevent pregnancy loss, targeting decidual immune cells (DICs) at the maternal‐fetal interface has been suggested. Although the phenotypic features and functions of DIC have been extensively profiled, the regulatory pathways for this unique immunological adaption have yet to be elucidated. In recent years, a pivotal mechanism has been highlighted in the area of immunometabolism, by which the changes in intracellular metabolic pathways in DIC and interaction with the adjacent metabolites in the microenvironment can alter their phenotypes and function. More inspiringly, the manipulation of metabolic profiling in DIC provides a novel avenue for the prevention and treatment of pregnancy loss. Herein, this review highlights the major metabolic programs (specifically, glycolysis, ATP‐adenosine metabolism, lysophosphatidic acid metabolism, and amino acid metabolism) in multiple immune cells (including decidual NK cells, macrophages, and T cells) and their integrations with the metabolic microenvironment in normal pregnancy. Importantly, this perspective may help to provide a potential therapeutic strategy for reducing pregnancy loss via targeting this interplay.
Two years into the pandemic massive investment in nursing is more urgent than ever
Authors: Catton Howard 
Published: May 2022

AbstractThe COVID‐19 pandemic has taught us some very painful lessons about underinvestment in healthcare and the lack of adequate preparation for a pandemic. In this article, ICN Chief Executive Officer Howard Catton examines the World Health Organization's review of global preparedness and looks to the future and how nursing can contribute to better planning and health outcomes for all.
Genotyping of respiratory syncytial virus among influenza‐like illness and severe acute respiratory infection cases of children in the Philippines from 2006 to 2016
Authors: Calaor‐Morin Jonjee , Arguelles Vina Lea , Foronda Janiza Lianne , Tan Alvin , Lagamayo Evelina , Dapat Clyde , Lupisan Socorro 
Published: May 2022

AbstractObjectiveRespiratory syncytial virus (RSV) is a leading cause of severe lower respiratory infection, and therefore, a major threat to global health. This study determined the epidemiological and molecular characteristics of RSV among cases of influenza‐like illness (ILI) and severe acute respiratory infection (SARI) among children in the Philippines.MethodThe study included archived nasopharyngeal swab and oropharyngeal swab samples collected from patients under the age of five who are presented with ILI or SARI for the period of 2006–2016. Swabs were examined for RSV subgroup by multiplex real‐time qRT‐PCR. Partial genome sequencing and phylogenetic analyses of the second hypervariable region (HVR) of the G gene were used to determine the genotype of RSV isolates.ResultsA total of 1036 representative samples from all sites were selected and tested. Of these samples, 122 were RSV‐positive at 11.8% prevalence rate, and 58.2% (71/122) were classified as RSV‐A. Six genotypes were identified, which include NA1 (27/122, 22.1%), ON1 (5/122, 4.1%), GA2 (1/122, 0.8%), and GA5 (1/122, 0.8%) for RSV‐A; and BA2 (13/122, 10.7%) and BA9 (1/122, 0.8%) for RSV‐B. Most RSV‐related cases were significantly associated with clinical characteristics such as runny nose (88.1% RSV vs. 11.9% non‐RSV: p value = 0.021), pneumonia (80.6% RSV vs. 19.4% non‐RSV; p value = 0.015), and bronchitis (71.7% RSV vs. 28.3% non‐RSV; p value < 0.001). Increased RSV‐related cases were observed among children below 24 months old.ConclusionThe RSV trend and genetic variability in the Philippines resembles a similar pattern of transmission globally.
Immediate post‐exercise blood pressure and arterial stiffness in hypertensive and normotensive older females
Authors: Costa Eduardo C. , Browne Rodrigo A. V. , Câmara Marcyo , Macêdo Geovani A. D. , Lucena Bruno E. B. , Vianna Lauro C. , Duhamel Todd A. 
Published: May 2022

AbstractAlthough it has been suggested that increased arterial stiffness is linked to exaggerated blood pressure (BP) from brief moderate exercise, it is not clear whether this occurs in older adults with and without hypertension. This study investigates whether the immediate post‐exercise systolic BP following brief moderate exercise is associated with arterial stiffness in older females with different BP status. This cross‐sectional study included 191 older females aged 60–80 years without known cardiovascular disease (CVD). Arterial stiffness was determined by aortic pulse wave velocity (aPWV). Systolic BP was measured before and immediately following a 3‐min moderate walking test (stage 1 Bruce protocol). Specific quartile‐based thresholds were used to define an exaggerated immediate post‐exercise systolic BP for hypertensive and normotensive older females (quartile 4 as an exaggerated response). Traditional CVD risk factors were assessed (covariates). Older females from the highest quartile of immediate post‐exercise absolute systolic BP showed higher aPWV compared to their peers from the lowest quartile (β = .22 m/s, p = .018). The quartile‐based threshold to define the exaggerated post‐exercise systolic BP was higher in hypertensive than in normotensive older females (174 vs. 172 mmHg). In summary, exaggerated immediate post‐exercise systolic BP following a brief moderate exercise is associated with higher arterial stiffness in older females with different BP status.
Farrerol alleviates collagenase‐induced tendinopathy by inhibiting ferroptosis in rats
Authors: Wu Yongfu , Qian Jun , Li Kang , Li Wenjun , Yin Wenhua , Jiang Huaji 
Published: May 2022

AbstractTendinopathy is mainly characterized by local pain, functional limitation and decreased athletic ability, which seriously affects the quality of life of patients and the career of athletes. Farrerol (FA), one of the main active compounds extracted from Rhododendron and plants in the Rhododendron family, has a wide range of pharmacological activities, such as immunomodulatory, anti‐inflammatory and antiviral effects. However, the effect of FA on tendinopathy is unclear. Here, we investigated the pharmacological effect and mechanism of FA in tendon injury through collagenase‐induced tendinopathy in vivo and RSL3‐induced tenocytes injury in vitro. The results showed that FA alleviated the infiltration of inflammatory cells, promoted tenogenesis and improved mechanical properties of the Achilles tendon in rats. In addition, ferroptosis inducer RSL3 inhibits the tenogenesis in vitro and in vivo, which accelerates the progression of tendinopathy. Moreover, FA effectively inhibited iron accumulation and alleviated ferroptosis in the Achilles tendon. Using in vitro experiments, we found that FA antagonized ferroptosis by reducing lipid peroxidation and iron accumulation in tenocytes. Finally, we found that glutathione peroxidase 4 silencing could block the protective effect of FA on ferroptosis of tenocytes. Therefore, the results of this study suggest that FA can relieve collagenase‐induced tendinopathy by inhibiting ferroptosis, and reveal that FA may be a potentially effective drug for the treatment of tendinopathy in the future.
Euroscepticism, Anti‐Nostalgic Nostalgia and the Past Perfect Post‐Brexit Future
Authors: Melhuish Francesca 
Published: May 2022

AbstractWhile extant work on British Euroscepticism has highlighted vestiges of historical empire imaginaries in discourses opposing EU integration, the emotional dynamics of such frames remain curiously underexplored. The diluted quality of these Eurosceptic histories, with their distinctive interplay of past and future, has led some to reject their nostalgic emotional credentials altogether. This article challenges such assumptions of emotional absence through a qualitative discourse analysis of the 2016 EU referendum Vote Leave campaign's materials, and interviews with 13 former campaigners. By unpacking Vote Leave's preference for an anti‐nostalgic form of empire nostalgia, central to its vision of a past perfect post‐Brexit future, this analysis contributes primarily to literatures on British Euroscepticism and Brexit, revealing the counterintuitive nostalgic politics and persistent cultural appeal of ostensibly forward‐looking discursive stances. The analysis also has broader relevance, particularly for advocates of an ‘emotional turn’ in EU Studies and scholars investigating escalating nationalisms beyond Britain.
Moral Panics, Viral Subjects: Black Women's Bodies on the Line during Cuba's 2020 Pandemic Lockdowns
Authors: Bastian Hope , Berry Maya J. 
Published: May 2022

AbstractWhile Cuba was in a COVID‐19‐induced lockdown, coleras, women who wait in hours‐long colas (lines) to purchase scarce goods to resell, emerged in online state media as “folk devils” responsible for the acute shortages of basic goods. Using an intersection lens, we combine fieldwork in lines and content analysis of online media to examine the creation and policing of the colera threat during the summer of 2020. Coleras were framed as immoral subjects, gendered and racialized, and often depicted as a virus that threatened the nation's health. The colera moral panic attempted to obscure class, race, and gender inequalities and structures that have made certain citizens vulnerable in the aftermath of successive waves of Cuban economic reforms. Understanding this moral panic allows us to appreciate the material scarcities and indignities to which poor Black women have been subjected, and widespread concerns about the state's failure to protect society's most vulnerable.
Measuring text similarity and its associated factors in electronic nursing progress notes: A retrospective review
Authors: Shala Danielle Ritz , Sheppard‐Law Suzanne 
Published: May 2022

AbstractAims and objectivesTo measure text similarity in electronic nursing progress notes and determine factors associated with text similarity.BackgroundElectronic clinical notes with redundant information masks clinically relevant information, increases clinicians’ cognitive burden and undermines patient safety.DesignRetrospective review of electronic medical record nursing progress notes.MethodsThe study was conducted between November 2018 and February 2019 in two Australian Paediatric Intensive Care Units. De‐identified, randomly selected inpatient data were extracted from the network's database. Manually classified shift summary progress notes for each admission were sequenced from admission to discharge. Text similarity was calculated for consecutive pairs of nursing progress notes. Linear regression was undertaken to determine the association between the similarity scores and variables of interest: note word count, total number of notes and unit. The STROBE checklist was used for reporting.Results921 shift summary nursing progress notes were analysed. Similarity scores were widely distributed with a median of 10.37%. Only 17.2% (n = 144) of the notes have similarity scores above 20%. Of these, 5% (n = 47) were above 50% similar in comparison with a previously written note. Similarity above 50% was observed as early as the first note pair in the course of a patient's admission. A significant difference was found between the similarity scores of Unit 1 and Unit 2. Hospital unit was the only variable of interest significantly associated with similarity scores.ConclusionText similarity among electronic nursing progress notes in Australian Paediatric ICUs is minimal; however, notes with >50% similarity have been identified. Text analytics provides measurable data and insights about electronic clinical documentation to inform future nursing practice, research and eMR design.Relevance to clinical practiceFindings have implications for nursing practice in the way that nursing staff are educated to maintain data quality, professional accountability and effective communication in electronic documentation and to avoid unnecessary repetition of text.
Myoepithelioma‐like tumors of the vulvar region: A case report and review of the literature
Authors: Liu Xu , Chen Lu , Zhou Quan , Liu Jiao , Hu Yuchang 
Published: May 2022

AbstractMyoepithelioma‐like tumors of the vulvar region (MELTVR) is a kind of solid tumor newly recognized in recent years, which is characterized by mesenchymal tumors of adult female vulva. The histopathology is similar to myoepithelioma, but the immunohistochemical phenotype and genetic changes are different from myoepithelioma. It usually has clear boundary and partial capsule, mixed with two forms of cells (epithelioid and spindle), the cells are mild, the nucleoli are clear, mitoses are rare, some cases have myxoid differentiation. In this article, a case of MELTVR diagnosed in our hospital is discussed. The patient was a 43‐year‐old female who finds a neoplasm in the pubic tubercle 4 months ago. Local resection was performed. Pathological examination showed that the boundary of the tumor was clear with partial capsule. The cells were arranged in cords or nests, and partially infiltrated the surrounding adipocytes. The tumor cells had two morphologies, epithelioid or spindle shaped. The spindle type cells were dominant, with bright cytoplasm, obvious nucleoli, rare nuclear mitosis (about 1/10HPF), and no necrosis was observed. Immunohistochemically, the tumor cells were positive for vimentin, epithelial membrane antigen, estrogen receptor, progestogen receptor, calponin and were partially positive for cathepsin k. INI1/SMARCB1 expression was deficient. There was no recurrence or metastasis during the 8‐month‐long follow‐up. The unique feature of this case was that the site of the disease was not the vulva, but in front of the pubic tubercle, there was no large amount of mucus production, and the cytoplasm of most tumor cells was transparent. Due to our limited knowledge of MELTVR, its pathogenesis and tissue origin are not clear. Clinicians should be aware of such potential patients.