bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a predictive model for the early occurrence of acute kidney injury in patients with acute pancreatitis
Authors: Wu Simin , Zhou Qin , Cai Yang , Duan Xiangjie 
Published: September 2022

Abstract
Background: Acute pancreatitis (AP) is associated with a high incidence of acute kidney injury (AKI), which has a high mortality rate. Currently, there is no clinically useful tool for predicting AKI in AP patients. Therefore, this study aimed to develop a predictive nomogram of the early onset of AKI in AP patients admitted to the intensive care unit (ICU).Method: Data were extracted from the Medical Information Mart for Intensive Care IV version 1.0 (MIMIC-IV version 1.0) database. Eligible patients were randomly divided into training and validation cohorts. The training cohort was used to construct the model, while the validation cohort was used to validate the model. The independent prognostic factors for the early (within seven days of admission) development of AKI in AP patients were determined using the all-subsets regression method. Subsequently, a nomogram was constructed to predict the early occurrence of AKI in AP patients. After that, multiple regression analysis was used to validate the predictive factors. Finally, we determined the area under the receiver operating characteristic curve (AUC) values, developed calibration curves and conducted decision curve analysis (DCA).Results: Seven independent prognostic factors, including age, ethnicity, total bilirubin, activated partial thromboplastin time, need for mechanical ventilation, use of vasoactive drugs, and sepsis, were identified as predictive factors for early onset AKI in AP patients. The constructed nomogram of the training cohort had an AUC value determined at a 95% confidence interval (95% CI) of 0.795(0.758-0.832). However, the nomogram for the validation cohort had an AUC value of 0.772(0.711-0.832, 95% CI).The AUC values of the nomogram were higher than those of the BISAP, Ranson, APACHE II scores, indicating that the nomogram had a good differentiation and discriminative ability. Further, the calibration curve revealed that the predictions had a high agreement with the actual observations. Finally, the DCA curves showed that the nomogram had a good clinical applicability value.Conclusion: The constructed nomogram showed a good predictive ability for determining the early occurrence of AKI in AP patients. The findings of this study are clinically useful in guiding clinicians in averting the development of AKI in AP patients.
Roles of the cerebellum and basal ganglia in temporal integration: insights gained from the synchronized tapping task
Authors: Tokushige Shin-ichi , Matsuda Shunichi , Tada Masayoshi , Yabe Ichiro , Takeda Atsushi , Tanaka Hiroyasu , Hatakenaka Megumi , Enomoto Hiroyuki , Kobayashi Shunsuke , Shimizu Kazutaka , Shimizu Takahiro , Kotsuki Naoki , Inomata-Terada Satomi , Furubayashi Toshiaki , Hanajima Ritsuko , Tsuji Shoji , Ugawa Yoshikazu , Terao Yasuo 
Published: September 2022

AbstractThe aim of this study was to clarify the roles of the cerebellum and basal ganglia for temporal integration. We studied 39 patients with spinocerebellar ataxia (SCA), comprising SCA6, SCA31, Machado–Joseph disease (MJD, also called SCA3), and multiple system atrophy (MSA). Thirteen normal subjects participated as controls. Participants were instructed to tap on a button in synchrony with isochronous tones. We analyzed the inter-tap interval (ITI), synchronizing tapping error (STE), negative asynchrony, and proportion of delayed tapping as indicators of tapping performance. The ITI coefficient of variation was increased only in MSA patients. The standard variation of STE was larger in SCA patients than in normal subjects, especially for MSA. Negative asynchrony, which is a tendency to tap the button before the tones, was prominent in SCA6 and MSA patients, with possible basal ganglia involvement. SCA31 patients exhibited normal to supranormal performance in terms of variability STE, which was surprising. In conclusion, cerebellar patients generally showed greater STE variability, except for SCA31. The pace of tapping was affected in patients with possible basal ganglia pathology. Our results suggest that interaction between the cerebellum and the basal ganglia is essential for temporal processing. The cerebellum and basal ganglia together with their interaction regulates synchronized tapping, resulting in distinct tapping patterns among different SCA subtypes.
The effect of geometric design and materials on section properties of additively manufactured lattice elements
Authors: Almalki Abduladheem , Downing David , Noronha Jordan , Dash Jason , Lozanovski Bill , Tino Rance , Alghamdi Ahmad , Khorasani Mahyar , Qian Ma , Brandt Milan , Leary Martin 
Published: September 2022

Abstract

Additive manufacturing (AM) technologies such as laser-based powder bed fusion (LB-PBF) facilitate the fabrication of complex lattice structures. However, these structures consistently display dimensional variation between the idealised and as-manufactured specimens. This research proposes a method to characterise the impact of common LB-PBF powders (aluminium and titanium alloys) and geometric design parameters (polygon order, effective diameter and inclination angle) on section properties relevant to stiffness and strength of as-manufactured strut elements will be quantified. Micro-computed tomography (µCT) will be applied to algorithmically characterise the as-manufactured variation and identify a scale threshold below which additional geometric resolution does not influence the section properties of as-manufactured parts. This methodology provides a robust and algorithmic, design for additive manufacturing (DFAM) tool to characterise the effects of manufacturing and design parameters on the functional response of AM strut elements, as is required for certification and optimisation.
F-MPSO: a hybrid metaheuristic approach based on the manifold distance for energy efficient-clustering in WSN
Authors: Aeini Faraein 
Published: September 2022

Abstract
This paper proposes an enhanced algorithm, called F-MPSO, for clustering to increase the lifetime of wireless sensor networks. Optimization for cluster head selection is a Non-Deterministic Polynomial (NP)-hard problem. The hybrid metaheuristic approach based on manifold distance has been introduced to cluster the sensor nodes. Our proposed method will enhance life because the Firefly approach is widely used for local updates, and the PSO approach is used for global updates and makes a reliable cluster. Wireless sensor networks aim to increase the entire network's lifetime. So, we propose a manifold-based metric to prefer the paths with the intermediate sensor with high residual energy to the straight distance between an ordinary node and cluster heads with low residual energy. The Matlab-based results obtained for the proposed F_MPSO algorithm and its comparison with the previous algorithm show efficient energy consumption using F_MPSO and successfully extending the network lifetime.
Falcarindiol attenuates cisplatin-induced nephrotoxicity through the modulation of NF-kB and Nrf2 signaling pathways in mice
Authors: Dolatpanah Mojtaba , Rashtchizadeh Nadereh , Abbasi Mehran Mesgari , Nazari Saeed , Mohammadian Jamal , Roshangar Leila , Argani Hassan , Ghorbanihaghjo Amir 
Published: September 2022

Abstract
Cisplatin is a therapeutic drug widely used to treat various solid tumors. Nephrotoxicity is a well-known side effect in patients treated with cisplatin. Falcarindiol (FAD), natural polyacetylene compound greatly found in Apiaceae family, has anti-cancer, -bacterial, -inflammatory and -oxidant activity which is utilized in the present study. Thirty male C57BL/6 mice were randomly divided into five groups of six each; sham, cisplatin (15 mg/kg), cisplatin + FAD (50 and 100 mg/kg/day), and FAD (100 mg/kg/day). Cisplatin administration elevated the concentrations of BUN and creatinine, as well as kidney histopathologic damage. On the other hand, FAD treatment attenuated cisplatin-induced injury, and also down-regulated mRNA levels of TNF-α and IL-1β together with protein expression of p-NF-kB p65. Moreover, FAD induced the protein expression of p-AMPK and nuclear Nrf2 accompanied by its respective target genes such as NQO-1 and HO-1 in a dose-dependent manner. In conclusion, the findings collectively characterize FAD as a drug candidate to treat cisplatin-induced nephrotoxicity thorough down-regulation of NF-kB signaling pathway in mice
Comprehensive bioinformatics analysis on exportins in lung adenocarcinoma and lung squamous cell carcinoma
Authors: Pan Meini , Huang Peng , Li Linmao 
Published: September 2022

Abstract
Background
Lung cancer is one of the most common malignant tumors in the world. Exportins are closely associated with the cellular activity and disease progression in a variety of different tumors. However, the expression level, genetic variation, immune infiltration and biological function of different exportins in LUAD and LUSC and their relationship with the prognosis of LUAD and LUSC patients have not been fully clarified.
Methods
In this study, ONCOMINE, UALCAN, HPA, Kaplan-Meier plotter, cBioPortal, STRING, DAVID, TIMER and LinkedOmics databases were used to analyze the differential expression, prognostic value, genetic variation, biological function and immune cell infiltration of exportins in patients with LUAD and LUSC.
Results
The transcriptional and protein expression levels of CSE1L and XPO1 / 5 / 6 / 7 were increased in LUAD and LUSC patients, and the increased transcriptional levels of CSE1L and XPO5 / 6 / 7 were related to worse prognosis. The increased transcriptional level of XPO1 suggested a better prognosis. These results indicated that CSE1L and XPO1 / 5 / 6 / 7 may be potential prognostic biomarkers for the survival of patients with LUAD and LUSC. Besides, the high mutation rate of exportins in NSCLC was 50.48%, and the largest proportion of mutations was high mRNA expression. The expression of exportins was significantly correlated with the infiltration of various immune cells. Differentially expressed exportins could regulate the occurrence and development of LUAD and LUSC by involving a variety of miRNAs and transcription factor E2F1.
Conclusions
Our study could provide novel insights for the selection of prognostic biomarkers of exportins in LUAD and LUSC.
Risk Factors for Reduced Function in Women with a History of Breast Cancer
Authors: Stoyles Nicholas , Cheville Andrea , Zucker David , Richards Blair , Vargo Mary , Gerber Lynn , Shahpar Samman , Henderson Maryanne , Jay Gina , Smith Sean 
Published: September 2022

Abstract
Purpose
Breast cancer patients are at risk of losing function during and after treatment. Unfortunately, little is known about the individual and additive effects of specific treatment, disease-related, and demographic factors that may contribute to functional decline. This manuscript reports the results of a multi-center study to evaluate the effects of these factors on function.
Methods
In this cross-sectional study, women with a history of breast cancer referred to cancer rehabilitation clinics were administered the PROMIS Cancer Function Brief 3D Profile to evaluate function in the domains of physical function, fatigue, and social participation. Clinical and demographic information, including treatment history and disease status, was recorded by clinicians. Patients were analyzed in two groups: those with active disease on antineoplastic treatment, and those with no evidence of disease (NED). A multivariable model was constructed to detect associations between clinical and demographic factors.
Results
In patients with NED, the presence of chemotherapy-induced peripheral neuropathy (CIPN) was strongly associated with reduced function in all three domains. In those with active disease, having brain metastases was significantly associated with reduced function in all domains and CIPN with reduced physical function. Radiation was associated with improved function in both cohorts.
Conclusions
Among women seeking rehabilitative care, CIPN and the presence of brain metastases were most strongly associated with a decline in function. The effects of radiation on function were unexpected and may be partially explained by the treatment’s role in symptom management. Clinicians who treat breast cancer should consider a patient’s functional status when providing supportive care.
Distribution of b-value in the central and southern Ryukyu: Is the low b-value in the rift-axis of the Okinawa Trough accurate?
Authors: Nakamura Mamoru 
Published: September 2022

Abstract
Here, I investigated whether the b-value in the rift-axis of the Okinawa Trough, a back-arc basin, is low. The cause of the low b-value in the rift-axis of the Okinawa Trough had previously been interpreted as increased stress by dyke intrusion. However, the previous study ignored the spatial variations in magnitude completeness in the Okinawa Trough. In addition, for the M4-class earthquakes that occurred in the Okinawa Trough, the values of displacement magnitudes and velocity magnitudes determined by the Japan Meteorological Agency (JMA) for the same events did not match. The previous study did not correct for these effects. Thus, I conducted these corrections and examined the spatial variation of b-values in the Okinawa Trough and the Ryukyu arc. The magnitude completeness was calculated using goodness-of-fit methods and the b-value was calculated using the maximum likelihood method. The JMA earthquake catalog from 2001 to 2019 was used for the analysis. After the corrections, the b-values around the rift-axis of the central and southern Okinawa Trough (0.90–0.92) were almost the same as those for the Ryukyu arc (0.83–0.84). Magnitude completeness in the Okinawa Trough varied spatially, and was particularly large in the earthquake swarm area in the rift-axis of the Okinawa Trough. The steady-state magnitude completeness was 2.0 in the earthquake swarm area in the rift-axis of the Okinawa Trough. However, the magnitude completeness increased to 3.5 or higher only during the several days of occurrence of the earthquake swarms. This was caused by the short-term decrease in the ability to detect earthquakes when an earthquake swarm occurred. The finding that the b-values do not differ between the rift-axis of the Okinawa Trough and the Ryukyu arc indicates that stress concentration in the rift-axis of the Okinawa Trough is not a strong influence on the b-values. Alternatively, this might indicate that in the rift-axis of the Okinawa Trough, the distribution of low and high b-value regions was not detectable due to the insufficient accuracy of hypocenter determination.
Pregnancy in Spina Bifida Patients: A Comparative Analysis of Peripartum Procedures and Complications
Authors: Sciscent Bao Y. , Bhanja Debarati , Daggubati Lekhaj C. , Ryan Casey , Hallan David R. , Rizk Elias B. 
Published: September 2022

Abstract
Purpose
Spina Bifida (S.B.) is caused by a failure in neural tube closure that can present with lower extremity sensory deficits, paralysis, and hydrocephalus. Medical advances have allowed increased pregnancies among S.B. patients, but management and pregnancy-associated complications have not been thoroughly investigated. The objective is to delineate peripartum procedures and complications in patients with S.B.
Methods
A national de-identified database, TriNetX, was retrospectively queried to evaluate pregnant S.B. patients and the general population. Procedures and complications were investigated using corresponding ICD-10 and CPT codes within 1 year of pregnancy diagnosis.
Results
11,405 SB patients were identified and compared to 9,269,084 non-S.B. patients. SB patients were significantly more likely to undergo cesarean delivery (1.200; 95% CI [1.133–1.271]) and less likely to receive neuraxial analgesia (0.406; 95% CI [0.383–0.431]). Additionally, patients with SB had an increased risk of seizures (3.922; 95% CI [3.529–4.360]) and venous thromboembolism (VTE) (3.490; 95% CI [3.070–3.969]). Risks of pre-eclampsia and hemorrhage were comparable. S.B. patients with hydrocephalus and Chiari malformation type 1 (CM-1) or type 2 (CM-2) were compared to patients without these comorbid conditions. This sub-group analysis showed a significantly increased risk of having cesarean deliveries (S.B. with hydrocephalus: 12.55%, S.B. with CM-1 or CM-2: 12.81% vs. S.B. without hydrocephalus or CM: 6.16%) and VTE (3.74%, 2.43% vs. 0.81%). There were also increased risks of hemorrhage and seizures and decreased use of neuraxial analgesia, but the sample size was insufficient.
Conclusion
S.B. patients were more likely to undergo cesarean section and exhibit peripartum complications compared to those without S.B.
Ultrasound-assisted green synthesis of poly(o-phenylenediamine)/zinc oxide nanohybrids for enhanced adsorption of Cu (II) from water: Kinetic, equilibrium, and thermodynamic studies
Authors: Jadoun Sapana , Fuentes Juan Pablo , Urbano Bruno F. , Yáñez Jorge 
Published: September 2022

Abstract
Fabricating novel eco-friendly adsorbents with excellent stability, outstanding adsorption capacity, facile separation, brilliant recyclability, and extensive Cu (II) ion removal capability remains challenging. To solve the pollution of Cu (II) ions from water resources, herein, novel nanohybrids of poly(o-phenylenediamine)/zinc oxide (POPD/ZnO) were synthesized using ultrasound-assisted technique via a facile in situ polymerization method following green chemistry principles. As prepared nanohybrids were characterized using infrared spectra (FTIR), UV-Visible spectra, scanning electron microscopy (SEM), X-ray scattering (XRD), and thermogravimetric analysis (TGA). The results revealed that ZnO nanoparticles were successfully incorporated into the POPD matrix and the stability of nanohybrids was found better than the POPD alone. Optimization of numerous parameters was done to see the performance of the adsorption process such as the effect of loading of OPD in nanohybrids, adsorbent dose, initial Cu (II) ion concentration, pH of the solution, contact time, and temperature. The nanohybrids POPD/ZnO-13/87 was found the best adsorbent according to the above analysis and used for the isotherm studies. The adsorption process was analyzed using a Non-linear equilibrium isotherm (Langmuir and Freundlich), kinetics (pseudo-first and second order, along with intraparticle diffusion model) and thermodynamic models. Langmuir isotherm and pseudo-second-order kinetic model were found appropriate for the adsorption process. Thermodynamic parameters (Gibbs free energy change (ΔG°), entropy change (ΔS°), and enthalpy change (ΔH°)) were calculated showing endothermic and spontaneous t process for adsorption of Cu (II) ions. According to Langmuir isotherm, the maximum adsorption capacity was found 2485 mg·g-1 that was higher than that of other reported materials till date. Mechanism studies suggested that the electrostatic interaction and cation-π interaction in between nanohybrids and Cu (II) ions was the main driving force for the adsorption of Cu (II) ions. The adsorption capability was enhanced using the nanohybridization of POPD/ZnO via ultrasonication technique in comparison to POPD and ZnO alone. These nanohybrids are efficient adsorbents to remove the maximum pollution of Cu (II) ions in a sustainable way by using the green synthesized POPD/ZnO nanohybrids.
Integrating liver and brain transcriptomic analyses provides new insights into the growth regulation mechanism of Rice flower carp
Authors: Li Zhe , Du Xuesong , Huang Yin , Li Yu , Jing Tingsen , Pan Xianhui , Zhou Kangqi , Wen Luting , Qin Junqi , Chen Zhong , Luo Hui , Lin Yong , Ye Hua 
Published: September 2022

Abstract
As the main economic fish species in integrated rice-fish farming, the growth performance of rice flower carp (Cyprinus carpio var. Quanzhounensis) directly affects farmers’ economic benefits. In this study, whole-brain and liver tissues of rice flower carp of different sizes were used for transcriptome analysis to identify differentially expressed genes (DEGs) in the two organs and to determine genes associated with the growth of rice flower carp. In the liver tissues, 28,186 genes were generated, including 880 DEGs. In the brain tissues, 50,373 genes were generated, including 2223 DEGs. Twelve and eight genes from the liver and brain, respectively, were selected for quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The high correlation between the expression of these genes in RNA-seq and qRT-PCR provided reliable transcriptome information. The transcriptome results suggested that the slow-growth individuals were affected by the feeding regulators, neuropeptide y (NPY) and cholecystokinin (CCK), less food was uptake and needed to maintain normal life activities through lipid metabolism and gluconeogenesis in the liver, thus, reducing the amount of energy available for growth and resulting in slow growth. This study provides new insights into the growth regulation mechanisms of rice flower carp and increases our understanding of growth regulation mechanisms in different fish species.
Intraocular pressure variation from ocular compression in low and high myopia
Authors: Xu Fang-yu , Kwok-cheung Lam Andrew 
Published: September 2022

Abstract
Introduction
Recent studies have monitored lamina cribrosa deformation using optical coherence tomography during ocular compression. Intraocular pressure (IOP) was measured only once immediately after ocular compression. This study aimed to evaluate IOP changes during and after ocular compression and compare the differences between low and high myopia.
Methods
Two groups of young, healthy adults were age-matched and underwent ocular compression. IOP was measured at baseline and monitored during a 2-min ocular compression followed by a 10-min recovery phase. Rebound tonometry was used and applied at 30-s intervals.
Results
Thirty low and 30 high myopes (60 right eyes) were included in the study. They had similar baseline IOP at 14.9mmHg. The immediate IOP rise was 10.2mmHg and 10.3mmHg from baseline in each group, respectively. Low myopes had faster IOP decay during ocular compression at -3.24mmHg/min than high myopes at -2.58mmHg/min (p = 0.0528). The IOP dropped below the baseline level after the release of the compressive force. Low myopes had IOP that returned to baseline levels faster (at 360 s) than high myopes (at 510 s).
Conclusion
Measuring IOP once immediately after ocular compression could under-estimate the effect of IOP increase on lamina cribrosa deformation. The difference in IOP dynamics from ocular compression between low and high myopia may be used to reflect aqueous humour outflow facilities.