bluuebunny/crossref_metadata_2025_split huggingface dataset:
INTERVENSI HINDIA BELANDA TERHADAP BIROKRASI KERAJAAN MUNA, 1910-1947
Authors: Inggraeni Herni , Aslim Aslim , Hadara Ali , Salebaran Salebaran 
Published: September 2022

Penelitian ini mengkaji tentang intervensi Hindia Belanda terhadap birokrasi Kerajaan Muna, 1910-1947 dengan tujuan untuk: (1) Menjelaskan struktur pemerintahan Kerajaan Muna tahun 1910-1947. (2) Menjelaskan intervensi Hindia Belanda terhadap birokrasi Kerajaan Muna tahun 1910-1947. (3) Menerangkan dampak dari intervensi Hindia Belanda terhadap birokrasi Kerajaan Muna tahun 1910-1947. Penelitian ini menggunakan metode sejarah yang terdiri dari lima tahapan, yakni (a) Pemilihan topik, (b) Heuristik sumber, (c) Verifikasi sumber, (d) Interpretasi sumber, (e) Historiografi. Adapun hasil penelitian menunjukkan bahwa: (1) Pascamasuknya Hindia Belanda struktur pemerintahan Kerajaan Muna mengalami perubahan, pertama pemerintahan pusat (gouvernement) terdiri dari aparat pemerintah dan aparat agama. Kedua, pemerintah daerah (swapraja) terdiri dari Raja (Omputo), Bhonto bhalano, Mintarano bhitara, Kapitalao, Ghoerano, Kino Bharata, Kino dan Mino. Fato Lindano, Parabhela, Kapita, Pengawal Raja. (2) Hindia Belanda melakukan intervensi pada birokrasi Kerajaan Muna seperti pengahapusan Dewan Sara, membentuk pemerintahan distrik, berwenang dalam memilih raja, mengubah sistem pemerintahan, serta menghapus beberapa kedudukan pejabat kerajaan. (3) Dampak dari intervensi Hindia Belanda terhadap birokrasi Kerajaan Muna yakni, menimbulkan gerakan perlawanan masyarakat pada Hindia Belanda, perubahan di bidang ekonomi, perubahan di bidang sosial, serta perubahan di bidang kebudayaan.
IDENTIFIKASI KEARIFAN LOKAL MASYARAKAT DI DESA MUARA SAMPARA KECAMATAN KAPOIALA KABUPATEN KONAWE SULAWESI TENGGARA
Authors: Burhan Faika , Malik Elmy Selfiana , Sarman Sarman , Latif Abdul , Hermina Sitti 
Published: September 2022

Penelitian ini bertujuan mendeskripsikan Kearifan Lokal Masyarakat di Desa Muara Sampara Kecamatan Kapoiala Kabupaten Konawe Sulawesi Tenggara. Penelitian ini bersifat deskripsi kualitatif melalui metode wawancara, observasi dan dokumentasi di lapangan. Hasil penelitian menunjukkan bahwa kearifan lokal Masyarakat Desa Muara Sampara Kecamatan Kapoiala dapat dilihat dalam bentuk aktivitas lalu lintas perahu dan pincara. Pembuatan dan penggunaan perahu dan pincara sudah dilakukan sejak tahun 1960-an, bahkan menurut informasi sebelumnya pincara pernah digunakan sebagai jalur lalu lintas perdagangan pada masa Kerajaan Konawe. Hal ini merupakan bentuk kearifan lokal masyarakat yang sudah dilakukan sejak dahulu hingga saat ini untuk mempertahankan hidup (2) sikap solidaritas kelompok masyarakat di Desa Muara Sampara Kecamatan Kapoiala terwujud dalam aktivitas gotong royong dalam mendukung pembangunan di Desa Muara Sampara. Sikap gotong royong tersebut terlihat dalam kegiatan sosial maupun budaya yang tercermin dalam perilaku masyarakat yang sederhana dalam jiwa kebersamaan. Kebersamaan etnis Bugis, Makassar dan Tolaki di Desa Muara Sampara terlihat dari sikap solidaritas dan sikap saling menghargai yang tetap terjaga hingga sekarang.
PERKEMBANGAN PELABUHAN LANGARA DAN DAMPAKNYA TERHADAP KEHIDUPAN SOSIAL EKONOMI MASYARAKAT WAWONII BARAT, KABUPATEN KONAWE KEPUALAUAN TAHUN 1995-2020
Authors: Herman Herman , Syahrun Syahrun , Mukadas Aswati , Hisna Hisna 
Published: September 2022

Penelitian ini bertujuan untuk untuk menjelaskan (1) latar belakang pembangunan dan perkembangan Pelabuhan Langara di Kecamatan Wawonii Barat, Kabupaten Konawe Kepulauan tahun 1995-2020, (2) dampak Pelabuhan Langara terhadap kehidupan sosial ekonomi masyarakat yang berada di Kecamatan Wawonii Barat, Kabupaten Konawe Kepulauan tahun 1995-2020. Penelitian ini menggunakan metode sejarah menurut Louis Gottschalk dengan melalui empat tahapan kerja antara lain: heuristik, kritik sumber, interpretasi sumber, dan historiografi atau penulisan sejarah. Hasil penelitian ini menunjukkan bahwa pembangunan Pelabuhan Langara di Kabupaten Konawe Kepulauan pada tahun 1995, dilatarbelakangi oleh keinginan masyarakat setempat untuk membangun sebuah pelabuhan. Pembangunan Pelabuhan Langara pada masa itu dianggap sangat penting bagi masyarakat setempat. Hal itu karena selain bertujuan untuk menghubungkan Pulau Wawonii dan Kota Kendari, Pelabuhan Langara juga berfungsi sebagai transaksi ekonomi masyarakat Wawonii khususnya yang berada di sekitar pelabuhan tersebut. Keberadaan Pelabuhan Langara memiliki peran penting dalam mendukung kelancaran transportasi laut masyarakat karena menjadi titik simpul yang menghubungan antardaerah Wawonii dan Kota Kendari. Pelabuhan Langara terus mengalami perkembangan dari tahun 1995-2020. Hal itu dapat dilihat dari jenis kapal yang berlabuh di Pelabuhan Langara misalnya jumlah kapal kayu dan kapasitas kapal ferry yang semakin meningkat, jumlah sarana-prasarana pelabuhan, seperti terminal penumpang, toilet, listrik, dan fasilitas lainnya terus bertambah. Pelabuhan Langara memiliki dampak bagi kehidupan sosial ekonomi masyarakat Wawonii. Hal demikian karena Pelabuhan Langara selain berperan sebagai tempat interaksi sosial masyarakat yang ingin melakukan aktivitas antarpulau juga menjadi tempat aktivitas ekonomi masyarakat masyarakat Wawonii.
Construction and properties of the silk fibroin and polypropylene composite biological mesh for abdominal incisional hernia repair
Authors: Luan Fengming , Cao Wangbei , Cao Chunhui , Li Baizhou , Shi Xiaoyu , Gao Changyou 
Published: September 2022

Background: In this study, a new composite biological mesh named SFP was prepared by combining silk fibroin with polypropylene mesh. The mechanism and clinical application value of the SFP composite mesh were explored.Methods: The fibrous membrane was prepared by electrospinning of silk fibroin. The silk fibrous membrane was adhered to the polypropylene mesh by fibrin hydrogel to make a new composite mesh. The characterizations were verified by structural analysis and in vitro cell experiments. A total of 40 Sprague–Dawley rats were randomly divided into two groups, and 20 rats in each group were implanted with the SFP mesh and pure polypropylene mesh, respectively. The rats were sacrificed in batches on the 3rd, 7th, 14th, and 90th days after surgery. The adhesion degree and adhesion area on the mesh surface were compared, and a histopathological examination was carried out.Results:In vitro cell function experiments confirmed that the SFP mesh had good cell viability. The control group had different degrees of adhesion on the 3rd, 7th, 14th, and 90th days after surgery. However, there was almost no intraperitoneal adhesions on the 3rd and 7th days after surgery, and some rats only had mild adhesions on the 14th and 90th days after surgery in the SFP group. There were statistically significant differences in the postoperative intraperitoneal adhesion area and adhesion degree between the two groups (p &lt; 0.05). Histopathological examination confirmed that the mesenchymal cells were well arranged and continuous, and there were more new capillaries and adipocyte proliferation under the mesenchymal cells in the SFP group.Conclusion: The SFP mesh shows good biocompatibility and biofunction in vitro and in vivo. It can promote the growth of peritoneal mesenchymal cells. The formation of a new mesenchymal cell layer can effectively reduce the extent and scope of adhesion between the mesh and abdominal organs. The SFP mesh will have a good application prospect in the field of abdominal wall hernia repair.
Non-invasive and quantitive analysis of flatfoot based on ultrasound
Authors: Jiang Zhende , Zhang Qianpeng , Ren Lei , Qian Zhihui 
Published: September 2022

Flatfoot is a common foot deformity that seriously affects the quality of life. The aim of this study is to develop an accurate and noninvasive method for the diagnosis of flatfoot based on B-mode ultrasound. In this study, 51 patients (the flatfoot group) and 43 healthy subjects (the control group) were included. The plantar fascia angle, a new measurement for use in the diagnosis of flatfoot is proposed, as determined using B-mode ultrasound. For comparison, the calcaneal pitch angle and medial cuneiform height were also measured using lateral X-radiography, based on traditional diagnostic methods. The intraclass correlation values of the plantar fascia angle, the calcaneal pitch angle, and the medial cuneiform height were all more than 0.95, and there is a moderate correlation (r = 0.51) between the medial cuneiform height and the calcaneal pitch angle, and an excellent correlation (r = 0.85) between the plantar fascia angle and the calcaneal pitch angle. The optimal cutoff value, sensitivity, and specificity for medial cuneiform height in flatfoot diagnosis were 12.8 mm, 93.0%, and 54.9%, respectively. The optimal cutoff value, sensitivity, and specificity for plantar fascia angle in flatfoot diagnosis were 9.8°, 97.7%, and 94.1%, respectively. The proposed plantar fascia angle has good sensitivity and specificity in diagnosing flatfoot, therefore supplying a new approach for the noninvasive diagnosis of flatfoot.
Fate of petroleum-based and plant-based teabags exposed to environmental soil conditions for one year
Authors: Mateos–Cárdenas Alicia 
Published: September 2022

Petroleum-based plastics are materials which have provided important industrial benefits from being lightweight and having low production costs. However, plastic pollution is pervasive and ubiquitous on all environments. This has led some industries to rapidly introduce the so called ‘bioplastics’ into the market by switching the conventional ones for new plant-based alternatives with similar properties. However, little is known about the fate of such alternatives especially in the open environment. In this novel study, the degradation of teabags from eight different brands was investigated, five petroleum based (cellulose-PP blend) and three plant-based (cellulose, cellulose-PLA blend and PLA). The degradation was tested under real-environmental soil conditions over a 12-month period. Fourier Transform Infrared Spectroscopy (FTIR-ATR) and Scanning Electron Microscopy (SEM) techniques were used to examine the change in polymer makeup and surface degradation of teabags at 3 weeks, 3.5, 6 and 12 months. Teabag dry weight and any retrieved fragments were measured over time. Teabags that contained a plastic blended to cellulose were brittle or degraded into smaller fragments after 3 weeks in soil. Parallel to this, the cellulose layer also degraded in this short timeline. Petroleum-based teabags produced the highest numbers of PP fragments overtime and fragmented teabags were still found after 12 months. Plant-based teabags made of cellulose only or a blend of cellulose-PLA were absent from soil samples after 3.5 months, including no fragments. Contrary to this, teabags made of PLA which were marketed as completely biodegradable, persisted completely intact in soil throughout all time points. The novel results from this study provide a perspective on plastic degradation in terrestrial sources. Based on these findings, it can be recommended that teabags mostly made of cellulose or cellulose blended with a bioplastic present in a smaller ratio, are a better alternative to petroleum-based or pure PLA plastics, in terms of rapid environmental degradation. Further studies should focus on their ecotoxicity, additive presence, microbial degradation and life cycle in order to draw a full environmental assessment.
Identification and validation of a prognostic risk model based on caveolin family genes for breast cancer
Authors: Tang Qiang , Wang Shurui , Di Ziyang , Li Huimin , Xu Kailiang , Hu Xin , Di Maojun 
Published: September 2022

Background: Breast cancer (BC) is the most vicious killer of women’s health and is accompanied by increased incidence and mortality rates worldwide. Many studies have demonstrated that caveolins (CAVs) were abnormally expressed in a variety of tumors and implicated in tumorigenesis and cancer progression. However, the role of CAVs in BC remains somewhat contentious.Methods: We comprehensively explored the expression and prognostic value of CAVs (CAV1-3) in BC utilizing public databases (ONCOMINE, TIMER, UALCAN, and TCGA databases). Then we constructed a prognostic model based on the expression profiles. Also, a prognostic nomogram was built to predict the overall survival (OS). We further investigated the relationship between this signature and immune cell infiltration and the mutational landscape in BC. The R package “pRRophetic” was used to predict chemotherapeutic response in BC patients. Finally, we employed loss-of-function approaches to validate the role of CAVs in BC.Results: We found that CAVs were significantly downregulated in various cancer types, especially in BC. Low CAV expression was closely related to the malignant clinicopathological characteristics and worse OS and relapse-free survival (RFS) in BC. Then we constructed a prognostic model based on the expression profiles of CAVs, which divided BC patients into two risk groups. The Kaplan–Meier analysis showed that patients in the high-risk group tend to have a poorer prognosis than those in the low-risk group. Multivariate analysis indicated that the risk score and stage were both independent prognostic factors for BC patients, suggesting a complementary value. The clinical profiles and risk module were used to construct a nomogram that could accurately predict the OS in BC. In addition, we found that patients in the low-risk group tend to have a relatively high immune status and a lower mutation event frequency compared to the high-risk group. Furthermore, this signature could predict the response to chemotherapy and immunotherapy. Finally, CAV depletion promoted the colony formation, migration, and invasion of BC cells.Conclusion: CAVs may serve as novel biomarkers and independent prognostic factors for BC patients. Also, the constructed signature based on CAVs may predict immunotherapeutic responses and provide a novel nomogram for precise outcome prediction of BC.
Ferroptosis-related gene signatures in neuroblastoma associated with prognosis
Authors: Chen Yiru , Li Zihao , Cao Qingtai , Guan Haoyu , Mao Longfei , Zhao Mingyi 
Published: September 2022

Background: Ferroptosis, a form of regulatory cell death, has been linked to the development of various tumors. Peripheral neuroblastoma (NB) is one of the most common extracranial solid tumors in children, and it has been proposed that regulating tumor cell ferroptosis may be a future treatment for NB. However, it is unclear how ferroptosis contributes to NB development.Methods: Expression data were collected from two independent cohorts (GEO and Arrayexpress databases). Univariate Cox analysis, multivariate Cox analysis, and the least absolute shrinkage and selection operator (Lasso) algorithm were applied to create a prognostic signature, whose performance was quantified using the area under the receiver operating characteristic curve (AUC) and Kaplan–Meier curves. A prognostic meta-analysis was used to test the suitability and stability of the FRG signature. Drug sensitivity analyses were performed using the data collected from Cell Miner™.Results:PROM2, AURKA, STEAP3, CD44, ULK2, MAP1LC3A, ATP6V1G2, and STAT3 are among the eight genes in the FRG prognostic signature, all of which were highly expressed in stage 1 NB, except AURKA. Furthermore, the high-risk group, which was stratified by signature, had a lower overall survival rate than the low-risk group. GSEA revealed that high-risk groups have more biological processes related to ferroptosis.Conclusion: Ferroptosis-related genes are expressed differently between stages 1 and 4 NB. The FRG signature successfully stratified NB patients into two risk groups and can accurately predict the overall survival in NB. In addition, we found that the gene AURKA might have the potential to be a prognostic marker in NB.
Updates on mesenchymal stem cell therapies for articular cartilage regeneration in large animal models
Authors: Liu Timothy P. , Ha Pin , Xiao Crystal Y. , Kim Sang Yub , Jensen Andrew R. , Easley Jeremiah , Yao Qingqiang , Zhang Xinli 
Published: September 2022

There is an unmet need for novel and efficacious therapeutics for regenerating injured articular cartilage in progressive osteoarthritis (OA) and/or trauma. Mesenchymal stem cells (MSCs) are particularly promising for their chondrogenic differentiation, local healing environment modulation, and tissue- and organism-specific activity; however, despite early in vivo success, MSCs require further investigation in highly-translatable models prior to disseminated clinical usage. Large animal models, such as canine, porcine, ruminant, and equine models, are particularly valuable for studying allogenic and xenogenic human MSCs in a human-like osteochondral microenvironment, and thus play a critical role in identifying promising approaches for subsequent clinical investigation. In this mini-review, we focus on [1] considerations for MSC-harnessing studies in each large animal model, [2] source tissues and organisms of MSCs for large animal studies, and [3] tissue engineering strategies for optimizing MSC-based cartilage regeneration in large animal models, with a focus on research published within the last 5 years. We also highlight the dearth of standard assessments and protocols regarding several crucial aspects of MSC-harnessing cartilage regeneration in large animal models, and call for further research to maximize the translatability of future MSC findings.
The application of acupuncture in cardiopathy: A bibliometric analysis based on Web of Science across ten recent years
Authors: Li Xiao , Yin Zihan , Ling Fayang , Zheng Qianhua , Li Xiang , Qi Wenchuan , Liang Fanrong 
Published: September 2022

BackgroundWith high morbidity and mortality, cardiopathy is a major component of cardiovascular disease, causing a huge burden of disease to public health worldwide. In recent years, research on acupuncture treatment of cardiopathies has been increasing. However, no bibliometric analysis has been conducted to systematically describe the research progress and hotspots in this field. Therefore, this study aimed to conduct a bibliometric analysis of the relevant literature to explore the current status and future development of acupuncture for cardiopathies.MethodsThe Web of Science (WoS) Core Collection Database was searched for literature related to acupuncture therapies for cardiopathies from 2011 to 2021. Using CiteSpace 5.8 R3, cooperation network diagrams of authors, institutions, countries and journals, keyword co-occurrences, and clustering were performed and analyzed.ResultsA total of 321 studies were included. Overall, the number of annual publications increased yearly. These publications came from 31 countries or regions, of which China and the United States made the greatest contributions. In total, 333 authors from 258 institutions participated in this field, and Beijing University of Chinese Medicine and Professor Fanrong Liang were the most published institution and author, respectively. Evidence-based Complementary and Alternative Medicine published the largest number of articles, and CIRCULATION was the most commonly cited journal. Based on co-occurrences and cluster analysis of 257 keywords, three research frontiers and hotspots were identified: acupuncture for blood pressure regulation, acupuncture for coronary heart disease, and acupuncture for regulation of heart rate. In these three research frontiers, the rostral ventrolateral medulla (RVLM) and autonomic nervous system (ANS) are the most popular mechanisms.ConclusionA stable development trend has formed in this field. Further research should focus on the role of acupuncture therapies in the treatment of hypertension or hypertensive heart disease, coronary heart disease, and arrhythmia based on the mechanisms related to the RVLM and ANS.
Electrocardiographic changes associated with SGLT2 inhibitors and non-SGLT2 inhibitors: A multi-center retrospective study
Authors: Wu Victor Chien-Chia , Chiu Kai-Pin , Wang Chun-Li , Hsu Chiu-Yi , Tu Hui-Tzu , Huang Yu-Tung , Chang Chih-Hsiang , Huang Chien-Hao , Kuo Chang-Fu , Chen Shao-Wei , Chu Pao-Hsien , Chang Shang-Hung 
Published: September 2022

BackgroundSodium-glucose co-transporter 2 (SGLT2) inhibitors has been shown with cardiovascular benefit in type 2 diabetes mellitus (T2DM) patients. However, its osmotic diuresis still concern physicians who may look for possible electrolyte imbalance. We therefore aimed to investigate electrocardiographic (ECG) changes associated with SGLT2 inhibitors.MethodsElectronic medical records from Chang Gung Research Database between January 1, 2001 and January 31, 2019 were searched for patients with ECG reports and patients on an oral hypoglycemic agent (OHA). We then separate these T2DM patients with EKG into those taking either SGLT2 inhibitors or non-SGLT2 inhibitors. We excluded patients with OHA use &lt;28 days, age &lt;18 years, baseline ECG QTc &gt; 500 ms, and ECG showing atrial fibrillation or atrial flutter. Propensity score matching (PSM) was performed between groups by age, sex, comorbidities, and medications (including QT prolonging medications). Conditional logistic regression and Firth's logistic regression for rare events were employed to compare the difference between SGLT2 and non-SGLT2 inhibitor patients.ResultsAfter exclusion criteria and PSM, there remained 1,056 patients with ECG on SGLT2 inhibitors and 2,119 patients with ECG on non-SGLT2 inhibitors in the study. There were no differences in PR intervals, QT prolongations by Bazett's or Fridericia's formulas, new onset ST-T changes, new onset CRBBB or CLBBB, and ventricular arrhythmia between the group of patients on SGLT2 inhibitors and the group of patients on non-SGLT2 inhibitors. There were no differences between the two groups in terms of cardiovascular death and sudden cardiac death. In addition, there were no differences between the two groups in terms of electrolytes.ConclusionsCompared with T2DM patients on non-SGLT2 inhibitors, there were no differences in PR interval, QT interval, ST-T changes, bundle-branch block, or ventricular arrhythmia in the patients on SGLT2 inhibitors. There were no differences in cardiovascular mortality between these two groups. In addition, there were no electrolyte differences between groups. SGLT2 inhibitors appeared to be well-tolerated in terms of cardiovascular safety.