bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid change in soil properties after converting grasslands to crop production
Authors: Strock Jeffrey S. , Johnson Jane M. F. , Tollefson David , Ranaivoson Andry 
Published: March 2022

AbstractChanges to land management over the last 150 years, primarily the conversion of perennial grasslands to agricultural production dominated by annual row crops, have greatly changed soil properties and reduced the soil's ability to infiltrate and store water in the soil profile. Direct near‐term response at the time of conversion of an uncultivated remnant prairie to row crops is rare, especially responses that include repeated measurements on the same parcel of land and resampling of soils to a depth of 1 m to document rapid changes in soil organic carbon, nitrogen, and selected soil physical properties related to hydraulic properties. The objective of this research was to measure changes in soil chemical and physical properties after the conversion of perennial grassland to annual row‐crop production. A before‐and‐after approach was used to compare soil properties from a 0.31‐ha field in southwest Minnesota. Cultivation resulted in a negative shift in soil properties. Two years postcultivation, there was an overall reduction in soil organic carbon of 18.6 Mg ha−1 for the 0–1.0 m soil profile. Infiltration rates and soil sorptivity exhibited significant decreases following cultivation. The average decrease in the mean postcultivation infiltration and sorptivity rates were 0.30 mm s−1 and 0.12 mm s−0.5, respectively. Bulk density increased on average by 0.10 Mg m−3 between 0–0.2 m and 0.14 Mg m−3 between 0.2–1.0 m. This work provided a rare glimpse of the vast shift in soil properties, which occurred when the plow ripped through virgin prairie decades ago during the massive expansion of agriculture.
Anxiety in Geoffroy's spider monkeys (Ateles geoffroyi): Can scratching be used as an indicator?
Authors: Dell'Anna Fabrizio , Schino Gabriele , Aureli Filippo 
Published: March 2022

AbstractSelf‐directed behavior, such as self‐scratching (hereafter, scratching), occurs in several taxa across the animal kingdom, including nonhuman primates. There is substantial evidence that scratching is an indicator of anxiety‐like emotions in a variety of nonhuman primate species. Despite its importance as a window into emotional states, few studies have investigated scratching in Platyrrhines. We investigated scratching patterns of 24 Geoffroy's spider monkeys (Ateles geoffroyi) belonging to a group living in theOtoch Ma'ax Yetel Koohprotected area in the Yucatàn peninsula (Mexico). We assessed whether scratching could be used as an indicator of anxiety levels in this species by testing predictions based on contexts and behaviors associated with risk and uncertainty. We found no effect of the subject's sex and age, subgroup size, male presence, and the occurrence of fusions between subgroups on scratching rates. Similarly, we found no effect of infant proximity on their mother's scratching rates. Supporting our prediction, we found evidence that isolation from conspecifics affected scratching rates as individuals scratched more frequently the more time they spent isolated. Being in proximity with a partner with a relationship characterized by uncertainty affected scratching rates as individuals scratched more frequently when in proximity with a partner with whom they engaged in embraces (an indicator of uncertainty) than when in proximity with a partner with whom they did not exchange embraces. Our study provides insight into the factors affecting scratching in Geoffroy's spider monkeys, suggesting that scratching may indicate anxiety in this species at least in some contexts and thus opening a window into the emotional experience of another Platyrrhine monkey species.
Synthesis of Chiral Covalent Organic Frameworks via Asymmetric Organocatalysis for Heterogeneous Asymmetric Catalysis
Authors: Li Fei , Kan Jing‐Lan , Yao Bing‐Jian , Dong Yu‐Bin 
Published: March 2022

AbstractA general and efficient organocatalytic asymmetric polymerization approach for the synthesis of chiral covalent organic frameworks (CCOFs) has been developed. With a chiral 2‐methylpyrrolidine catalyst, a series of tris(N‐salicylideneamine)‐derived β‐ketoenamine‐CCOFs are directly constructed from prochiral aldehyde‐ and primary amine‐monomers. The adopted aminocatalytic asymmetric Schiff‐base condensation herein is performed under ambient conditions with clear green synthetic advantages over the conventional acid‐catalysed solvothermal methods. The obtained β‐ketoenamine‐CCOFs can be further metalated by a solid‐state coordination approach, and the resulting CuII@CCOFs can highly promote an asymmetric A3‐coupling reaction. Specifically, a CuII@CCOF@chitosan aerogel was fabricated as a highly efficient fixed‐bed model reactor for scaled‐up catalysis. The concept of aminocatalytic asymmetric polymerization might open a new way for constructing the CCOFs via asymmetric organocatalysis.
Cu microcrystals garnished with copper nanoparticles catalyzed one‐pot facile synthesis of novel 1,2,3‐triazoles via click chemistry as antifungal agents
Authors: Kodasi Barnabas , Joshi Shrinivas D. , Kamble Ravindra R. , Keri Rangappa S. , Bayannavar Praveen K. , Nesaragi Aravind R. , Dixit Shruti , Vootla Shyam Kumar , Metre Tukaram V. 
Published: March 2022

AbstractA remarkable, efficacious, and environmental friendly one‐pot procedure affianced for the synthesis of 1,2,3‐triazoles by 1,3‐dipolar cycloaddition of aromatic azides, terminal alkynes over Cu microcrystals (CuMCs) by click chemistry as subsequent way. The predominance of this method is green synthetic pathway, transient reaction times, facile workup, exceptional yields (87% to 90%) with excellent purity, regioselective single product formation, and eco‐friendliness of the CuMCs catalyst. Docking studies manifested strong binding interactions with enzyme sterol 14‐alpha‐demethylase (PDB ID: 3KHM) with excellent C‐score values. The antifungal screening of synthesized compounds revealed promising activity.
Artificial aquatic habitats impoverish amphibian diversity in agricultural landscapes of central Argentina
Authors: Perrone Sofía Micaela , Deutsch Camila , Bilenca David Norberto , Agostini María Gabriela 
Published: March 2022

Abstract

In central Argentina, agro‐ecosystems constitute the dominant landscape, representing the replacement of extensive grassland areas by crops and pastures. Agriculture has caused the loss of extensive areas of Pampean inland wetlands through drainage and the construction of artificial aquatic habitats such as ditches and ponds.
This study evaluated the availability and amphibian breeding use of 194 natural and artificial open water habitats and identified those attributes that affect amphibian diversity (richness, abundance and species occurrence).
Interviews with farmers revealed that all artificial ditches, drainage channels and ponds were constructed directly or indirectly to support agricultural activities, and 61.5% of them were created at the expense of natural wetlands. The results from generalized linear mixed models) indicated a significant decrease (P < 0.05) in amphibian richness (14.2–35.7%) and abundance (35.3–86.6%) in artificial habitats compared with natural habitats.
Overall, vegetation cover, average depth and edge slope emerged as the most important attributes affecting amphibian diversity in artificial open water habitats. Vegetation cover had a significant (P < 0.05) positive influence on species richness and abundance, whereas average depth and edge slope had the opposite effect.
Given the substantial modification of inland wetlands in central Argentina, natural aquatic habitats should be considered top priorities for conservation, and law enforcement is urgently needed to control the drainage and levelling of lagoons, ponds and low‐lying areas. The appropriate design and planning of constructed wetlands, including shallow depth and slightly sloping edges, could greatly improve the ability of artificial wetlands to favour native amphibians in these altered landscapes.
Artificial wetlands could offer complementary habitats to natural habitats for amphibians and aquatic wildlife if actions leading to sustainable management and territorial planning are applied.
Pre‐incubation conditions determine the fermentation pattern and microbial community structure in fermenters at mild hydrostatic pressure
Authors: Ceron‐Chafla Pamela , García‐Timermans Cristina , de Vrieze Jo , Ganigué Ramon , Boon Nico , Rabaey Korneel , van Lier Jules B. , Lindeboom Ralph E. F. 
Published: March 2022

AbstractFermentation at elevated hydrostatic pressure is a novel strategy targeting product selectivity. However, the role of inoculum history and cross‐resistance, that is, acquired tolerance from incubation under distinctive environmental stress, remains unclear in high‐pressure operation. In our here presented work, we studied fermentation and microbial community responses of halotolerant marine sediment inoculum (MSI) and anaerobic digester inoculum (ADI), pre‐incubated in serum bottles at different temperatures and subsequently exposed to mild hydrostatic pressure (MHP; < 10 MPa) in stainless steel reactors. Results showed that MHP effects on microbial growth, activity, and community structure were strongly temperature‐dependent. At moderate temperature (20°C), biomass yield and fermentation were not limited by MHP; suggesting a cross‐resistance effect from incubation temperature and halotolerance. Low temperatures (10°C) and MHP imposed kinetic and bioenergetic limitations, constraining growth and product formation. Fermentation remained favorable in MSI at 28°C and ADI at 37°C, despite reduced biomass yield resulting from maintenance and decay proportionally increasing with temperature. Microbial community structure was modified by temperature during the enrichment, and slight differences observed after MHP‐exposure did not compromise functionality. Results showed that the relation incubation temperature—halotolerance proved to be a modifier of microbial responses to MHP and could be potentially exploited in fermentations to modulate product/biomass ratio.
Risk assessment, development and validation of a GC‐ECD‐based method for the quantification of cypermethrin from green pea
Authors: Jan Ishrat , Dar Alamgir A. , Wani Ashraf A. , Mukhtar Malik , Sofi Javid A. , Hassan G. I. 
Published: March 2022

AbstractThe present work describes the persistence, dissipation behaviour, half‐life, risk assessment and novel gas chromatography method for the residue estimation of cypermethrin in green pea by spraying cypermethrin 10EC at 50 g a.i. ha−1 at fruiting stage followed by another application at a 10 day interval. The sample extraction and cleanup was followed bya modified quick, easy, cheap, effective, rugged, and safe method, and the residues of cypermethrin were determined using a validated gas chromatography method. The initial deposits were found to be 1.21 mg kg−1 following the application of insecticide at 50 g a.i. ha−1. Cypermethrin residues declined to below the detection limit of 0.05 mg kg−1 after 15 days at the recommended dosage. The half‐life of cypermethrin was 2.66 days at 50 g a.i. ha−1. For risk assessment studies, the waiting period of 15 days is recommended as safe for consumption for the insecticide. The GC‐ECD method was validated according to the SANTE guidelines by various analytical parameters including linearity, accuracy, detection and quantification limits. The developed method is simple, selective and repeatable, and can be used for the standardization of pesticides on fruits and vegetables.
The role of hypertension and diabetes mellitus on the etiology of middle cerebral artery disease
Authors: Zhang Changqing , Li Zixiao , Liu Liping , Pu Yuehua , Zou Xinying , Yan Hongyi , Pan Yuesong , Zhao Xingquan , Wang Yilong , Wang Yongjun 
Published: March 2022

AbstractBackgroundIschemic stroke (IS) caused by middle cerebral artery (MCA) disease is the most common type of IS caused by intracranial artery disease in the Chinese population. Hypertension and diabetes mellitus are the common risk factors of cerebral small vessel disease and large artery atherosclerosis (LAA). However, little is known about whether hypertension and diabetes mellitus had different correlations with the small artery occlusion (SAO) and LAA etiology of MCA disease. Therefore, our aim was to identify the predictors of the etiology of MCA disease.MethodsWe consecutively enrolled 967 patients with noncardiogenic IS in unilateral MCA territory. Vascular risk factors and the clinical–radiologic features of IS were analyzed. The etiology of IS were classified as SAO or LAA according to the Stop Stroke Study Trial of Org 10172 in Acute Stroke Treatment classification criteria. Multivariable logistic regression was used to identify the differences in the predictors between SAO and LAA etiology of MCA disease.ResultsMultivariable logistic regression identified male and hypertension as the predictors of the SAO etiology of MCA disease, however diabetes mellitus, repeated transient ischemic attack before the stroke, gaze palsy, aphasia, headache at admission, and disability at discharge as the predictors of the LAA etiology of MCA disease.ConclusionHypertension and diabetes mellitus are related with the different etiology of MCA disease.
The bioeconomy transformation as an external enabler of sustainable entrepreneurship
Authors: Hinderer Sebastian , Kuckertz Andreas 
Published: March 2022

AbstractBioeconomy strategies worldwide emphasize the importance of entrepreneurship in the transformation toward a sustainable and circular bioeconomy. However, the bioeconomy transformation itself also offers great opportunities for creating new ventures. Based on interviews with bioeconomy entrepreneurs from six European countries, we investigate how entrepreneurial opportunities emerge in the bioeconomy context and what competencies entrepreneurs need to act on them. By conceptualizing the bioeconomy transformation as an external enabler of entrepreneurial activity, we open new avenues for research on sustainable development and innovation policy. We conceptualize sustainable entrepreneurship as a phenomenon that can be enabled externally via the transformation toward sustainable development. Furthermore, we show that new venture creation in the bioeconomy requires unique knowledge (transformative knowledge) and specific competencies (sustainable valorization of biomass, marketing of biobased products, and management of limited resources).
The deep brachial artery—A meta‐analysis of its origin and diameter with a review of the literature
Authors: Przybycień Wojciech , Bonczar Michał , Ostrowski Patryk , Koziej Mateusz , Mizia Ewa , Wysiadecki Grzegorz , Loukas Marios , Walocha Jerzy 
Published: March 2022

AbstractThe deep brachial artery (DBA) is the first and largest branch of the brachial artery. Multiple variations of the DBA's origin, termination, and diameter have been reported in the literature. Major online medical databases such as PubMed, Scopus, Embase, Web of Science, and Google Scholar were searched in order to find all studies considering origin variations and the diameter of the DBA. The prevalence of the DBA originating directly from the axillary or brachial artery was shown to be 92.87%. DBA originating indirectly from the axillary or brachial artery, as a common trunk with other arteries, was found to be 7.13%. The mean diameter of the DBA was shown to be 2.05 mm. The authors of the present study believe that this is the most accurate and up‐to‐date meta‐analysis considering origin patterns and the diameter of the DBA. Additionally, this study contains a comprehensive literature review in which current detailed anatomical knowledge concerning the DBA was gathered. The results of this study could provide a helpful tool for physicians, especially surgeons, dealing with an upper limb in their daily practice.
A WIN Consortium phase I study exploring avelumab, palbociclib, and axitinib in advanced non‐small cell lung cancer
Authors: Solomon Benjamin , Callejo Ana , Bar Jair , Berchem Guy , Bazhenova Lyudmila , Saintigny Pierre , Wunder Fanny , Raynaud Jacques , Girard Nicolas , Lee J. Jack , Sulaiman Raed , Prouse Bruce , Bresson Catherine , Ventura Hila , Magidi Shai , Rubin Eitan , Young Brandon , Onn Amir , Leyland‐Jones Brian , Schilsky Richard L. , Lazar Vladimir , Felip Enriqueta , Kurzrock Razelle 
Published: March 2022

AbstractBackgroundThe Worldwide Innovative Network (WIN) Consortium has developed the Simplified Interventional Mapping System (SIMS) to better define the cancer molecular milieu based on genomics/transcriptomics from tumor and analogous normal tissue biopsies. SPRING is the first trial to assess a SIMS‐based tri‐therapy regimen in advanced non‐small cell lung cancer (NSCLC).MethodsPatients with advanced NSCLC (no EGFR, ALK, or ROS1 alterations; PD‐L1 unrestricted; ≤2 prior therapy lines) received avelumab, axitinib, and palbociclib (3 + 3 dose escalation design).ResultsFifteen patients were treated (five centers, four countries): six at each of dose levels 1 (DL1) and DL2; three at DL3. The most common ≥Grade 3 adverse events were neutropenia, hypertension, and fatigue. The recommended Phase II dose (RP2D) was DL1: avelumab 10 mg/kg IV q2weeks, axitinib 3 mg po bid, and palbociclib 75 mg po daily (7 days off/21 days on). Four patients (27%) achieved a partial response (PR) (progression‐free survival [PFS]: 14, 24, 25 and 144+ weeks), including two after progression on pembrolizumab. Four patients attained stable disease (SD) that lasted ≥24 weeks: 24, 27, 29, and 64 weeks. At DL1 (RP2D), four of six patients (66%) achieved stable disease (SD) ≥6 months/PR (2 each). Responders included patients with no detectable PD‐L1 expression and low tumor mutational burden.ConclusionsOverall, eight of 15 patients (53%) achieved clinical benefit (SD ≥ 24 weeks/PR) on the avelumab, axitinib, and palbociclib combination. This triplet showed antitumor activity in NSCLC, including in tumors post‐pembrolizumab progression, and was active at the RP2D, which was well tolerated.NCT03386929 clinicaltrial.gov
Impact of body mass index on perioperative and oncological outcomes in elderly patients undergoing minimally invasive McKeown esophagectomy for esophageal squamous cell carcinoma
Authors: Tong Chaoyang , Lu Huijie , Zhu Hongwei , Wu Jingxiang 
Published: March 2022

AbstractBackgroundThe association between elevated body mass index (BMI) and perioperative and oncological outcomes among elderly patients undergoing minimally invasive McKeown esophagectomy (MIE) remains unclear.MethodsWe performed a single‐center retrospective analysis of 526 consecutive patients aged 65 years or older who underwent MIE for esophageal squamous cell carcinoma (SCC) between January 2016 and December 2019. Two groups were stratified by BMI: normal (18.5 ≤ BMI < 24 kg/m2) and elevated groups (BMI ≥ 24 kg/m2). A 1:1 propensity score matching (PSM) analysis was used to compare perioperative and oncological outcomes between the two groups.ResultsA total of 480 elderly patients were eventually enrolled, with a mean age of 70.2 years (range: 65–87), and 185 patients were eligible for elevated BMI, with a mean BMI of 26.3 ± 1.9 kg/m2. Compared with the normal BMI group, the elevated BMI group had prolonged operation time (261.7 ± 57.2 vs. 278.9 ± 62.7 mins, p = 0.002) and increased incidence of intraoperative hypoxemia (12.2% vs. 21.6%, p = 0.006). The differences in intraoperative estimated blood loss, transfusion, new‐onset arrhythmia, and conversion rates and postoperative outcomes regarding pulmonary and surgical complications, intensive care unit and 30‐day readmissions, the length of hospital stay, and oncological outcomes regarding R0 dissection, and the number of dissected lymph nodes between two groups were comparable. After a 1:1 PSM analysis, there was no significant difference in both perioperative and oncological outcomes between two groups.ConclusionsAmong elderly patients undergoing MIE for esophageal SCC, there was insufficient evidence to demonstrate that elevated BMI could increase perioperative and oncological adverse outcomes.
Giant cell arteritis with rare manifestations of stroke and internal carotid artery dissection: A case study
Authors: Hashami Leila , Haj Mohamad Ebrahim Ketabforoush Arsh , Nirouei Matineh 
Published: March 2022

AbstractGiant cell arthritis is a systemic vasculitis. A 51‐year‐old man was presented with sudden onset of right‐side blurred vision, frozen movements, and ptosis in the right eye and left side paresis. The diagnosis of GCA with first manifestations of stroke and carotid dissection may be neglected as an underlying cause.
Successful approach for couples having their own genetic offspring using vitrified‐warmed oocytes injected by frozen‐thawed poor quality testicular sperm: A case report
Authors: Safari Somayyeh , Amouzegar Hoora , Ashourzadeh Sareh , Hosseini Elham 
Published: March 2022

AbstractThe clinical applications of donated gametes are approved in many countries; however, attitudes toward its application and national legislation in some countries are challenging. The purpose of this study is to report a healthy live birth produced by vitrified‐warmed oocytes and frozen‐thawed testicular sperms to avoid sperm donation.
Novel use of a Synovis™ coupler device for a surgical lymphovenous anastomosis for the treatment of refractory chylothorax in a patient with central lymphatic flow disorder
Authors: Rezkalla Joshua , Husain Majid , Slack Ginger , Sinha Sanjay 
Published: March 2022

AbstractRefractory post‐operative chylothorax in congenital heart disease is difficult to treat. We present a case of intractable neonatal chylothorax after cardiac surgery due to central lymphatic flow disorder that was treated by creating a lymphovenous anastomosis of the thoracic duct to the left external jugular vein for definitive treatment.
Transient flare of psoriasis under direct‐acting antiviral therapy of chronic hepatitis C: A case report
Authors: Dold Leona , Hausen Annekristin , Langhans Bettina , Strassburg Christian P. , Spengler Ulrich 
Published: March 2022

AbstractExtrahepatic manifestations of chronic hepatitis C virus (HCV) infection frequently involve the skin. Here, we report the case of a woman, who experienced a psoriasis exacerbation on DAA treatment, which lead to psoriasis resolution upon HCV clearance under continued treatment with elbasvir/grazoprevir.