bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the predictive ability of the Johns Hopkins Fall Risk Assessment Tool (Chinese Version) in inpatient settings
Authors: Chen Yadan , Lv Limin , Wu Chunni , Wen Huan , Cai Hongxia , Xiao Yujuan , Zhu Haihua 
Published: July 2022

AbstractAimsThis study was to assess the predictive ability of the Johns Hopkins Fall Risk Assessment Tool (Chinese Version) in inpatient settings.DesignA case–control study.MethodsThis study was conducted in a tertiary hospital based on 2019 data. With a case–control design in a 1:2 ratio, the predictive ability of the Johns Hopkins Fall Risk Assessment Tool (Chinese Version) was determined by ROC curve. The best cut point was identified based on sensitivity, specificity, positive predict value and negative predict value. Conditional logistical regression analysis was conducted to test the predictive ability of each indicator.ResultsThe study included 309 patients, with 103 in the case group and 206 in the control groups. Generally, the predictive ability was acceptable with the area under ROC curve value at 0.73 (95% CI: 0.67–0.79). Positive predict value and negative predict value performed best at the cut point of 13. Sensitivity at cut point 6 was much higher than that at cut point 13, though specificity was lower. Except for age, all indicators in the Johns Hopkins Fall Risk Assessment Tool (Chinese Version) demonstrated significant predictive ability as to occurrence of fall.ConclusionThe Johns Hopkins Fall Risk Assessment Tool (Chinese Version) is a reliable assessment instrument in the inpatient settings.ImpactThis is the first study that evaluated the predictive ability of the Johns Hopkins Fall Risk Assessment Tool (Chinese version) in the inpatient settings, and proved that the instrument is reliable for assessing inpatient fall risks. Further studies could be carried out to assess the predict ability of Johns Hopkins Fall Risk Assessment Tool (Chinese version) among specific populations.
Promoting community institutional partnerships to improve the health of intimate partner violence survivors experiencing homelessness
Authors: Jagasia Emma , Lee Jennifer J. , Wilson Patty R. 
Published: July 2022

AbstractBackgroundDisparities faced by individuals experiencing homelessness pose significant threats to the health and wellbeing of communities. Survivors of intimate partner violence are at heightened risk, with over 80% experiencing homelessness at some point in time. The intersection of homelessness and survivorship creates numerous barriers to care including safety concerns, stable housing, employment and childcare needs. The establishment of community institutional partnerships offers an opportunity to provide healthcare in transitional housing settings.AimsThe aim of this paper is to discuss the need for community institutional partnerships in addressing the health needs of intimate partner violence survivors and provide a working example of an existing partnership.MethodsA critical literature review of the literature was conducted. Multiple databases were searched to identify articles relating to health services, community institutional partnerships, intimate partner violence and sheltered housing. Articles were reviewed using The Johns Hopkins Nursing Evidence‐Based Practice Quality Guide.FindingsThree types of partnerships that can be leveraged to address the needs of individuals experiencing homelessness were identified: academic‐community, hospital‐community, and large‐scale partnerships. Only one article was identified that focused on the health needs of survivors experiencing homelessness, pointing to the need for implementation of more community institutional partnerships to address the unique needs of homeless intimate partner violence survivors. We highlighted a current successful community institutional partnership that addresses the health needs of survivors living in an emergency shelter.ImplicationsAddressing the complex needs of this population is imperative to dismantle health inequities and structural barriers to healthcare. Holistic, nurse‐led approaches to care are essential to address the health of intimate partner violence survivors experiencing homelessness. The example of a successful community institutional partnership provides a framework for delivering a wide range of healthcare services. Future nursing research is needed to evaluate programmes and provide foundational support for increased funding.
A rapid review of the impact of COVID‐19 on clinical supervision practices of healthcare workers and students in healthcare settings
Authors: Martin Priya , Tian Esther , Kumar Saravana , Lizarondo Lucylynn 
Published: July 2022

AbstractAimsTo synthesize available data on the impact of the COVID‐19 pandemic on clinical supervision practices of healthcare workers and students in healthcare settings.DesignA quantitative rapid review of the literature.Data SourcesA search of MEDLINE, Embase, PsycINFO, the Cochrane Library and Scopus for English language papers published between December 2019 (initial onset of the pandemic) to March 2021.Review methodsUsing the World Health Organization and Cochrane guidelines for rapid reviews, following an identification of relevant papers and data extraction, a narrative synthesis approach was used to develop themes.ResultsEight studies met the inclusion criteria. Four themes identified from data synthesis were nature and extent of disruptions to clinical supervision, unmet need for psychological support, supervisors also need support and unpacking telesupervision. Findings highlight the extent and nature of disruption to clinical supervision at the point of care. Further information on factors that facilitate high‐quality telesupervision have come to light.ConclusionThe COVID‐19 pandemic has placed tremendous burden on healthcare workers compromising their own health and well‐being. It is essential to restore effective clinical supervision practices at the point of care, so as to enhance patient, healthcare worker and organizational outcomes into the post‐COVID‐19 pandemic period.ImpactThis review has provided initial evidence on the adverse impacts of the COVID‐19 pandemic on clinical supervision of healthcare workers and students at the point of care. Available evidence indicates the urgent need to restore effective and high‐quality clinical supervision practices in health settings. The review has highlighted a paucity of studies in this area, calling for further high‐quality studies.
In vitro radiosensitization of breast cancer with hypoxia‐activated prodrugs
Authors: Aiyappa‐Maudsley Radhika , Elsalem Lina , Ibrahim Ali I. M. , Pors Klaus , Martin Stewart G. 
Published: July 2022

AbstractKP167 is a novel hypoxia‐activated prodrug (HAP), targeting cancer cells via DNA intercalating and alkylating properties. The single agent and radiosensitizing efficacy of KP167 and its parental comparator, AQ4N, were evaluated in 2D and 3D cultures of luminal and triple negative breast cancer (TNBC) cell lines and compared against DNA damage repair inhibitors. 2D normoxic treatment with the DNA repair inhibitors, Olaparib or KU‐55933 caused, as expected, substantial radiosensitization (sensitiser enhancement ratio, SER0.01 of 1.60–3.42). KP167 induced greater radiosensitization in TNBC (SER0.01 2.53 in MDAMB‐231, 2.28 in MDAMB‐468, 4.55 in MDAMB‐436) and luminal spheroids (SER0.01 1.46 in MCF‐7 and 1.76 in T47D cells) compared with AQ4N. Significant radiosensitization was also obtained using KP167 and AQ4N in 2D normoxia. Although hypoxia induced radioresistance, radiosensitization by KP167 was still greater under 2D hypoxia, yielding SER0.01 of 1.56–2.37 compared with AQ4N SER0.01 of 1.13–1.94. Such data show KP167 as a promising single agent and potent radiosensitiser of both normoxic and hypoxic breast cancer cells, with greater efficacy in TNBCs.
Prenatal exposure to nickel and atopic dermatitis at age 3 years: a birth cohort study with cytokine profiles
Authors: Ho J.C. , Wen H.J. , Sun C.W. , Tsai S.F. , Su P.H. , Chang C.L. , Sun H.L. , Wang S.L. , Lee C.H. 
Published: July 2022

AbstractBackgroundNickel, the fifth most common element on Earth, is the leading inducer of contact allergies in humans, with potent immunological effects. Nickel‐induced contact allergies predominantly affect females. Maternal exposure to nickel has been associated with several developmental abnormalities. However, how a maternal nickel exposure affects the development of atopic diathesis and immune abnormalities in children has never been addressed.ObjectivesWe aimed to determine whether maternal nickel exposure affects the development of atopic dermatitis and immune abnormalities in their children.MethodsUsing a birth cohort study, we analysed 140 mother–child pairs recruited in 2012–2015 from central Taiwan. Maternal exposure to nickel was estimated using urinary nickel levels measured by inductively coupled plasma mass spectrometry (ICP‐MS). The serum levels of 65 analytes and IgE in 3‐year‐old children were profiled with a multiplex ELISA. The correlation between the maternal urinary nickel concentration and serum analyte levels was assessed using Spearmen's correlation. Multivariant regression analysis was performed to evaluate the association between maternal urinary nickel levels and serum analyte concentrations in their children.ResultsThe geometric means of the maternal urinary nickel and the children's serum IgE levels were 2.27 μg/L and 69.71 IU/mL, respectively. The maternal nickel exposure was associated with increased serum levels of IL‐1β, IL‐2, TNF‐α, and leukaemia inhibitory factor (LIF) but with decreased serum levels of matrix metalloproteinase‐1 (MMP‐1), IL‐2R, and eotaxin‐1 in the children. In addition, the development of childhood atopic dermatitis at 3 years old was significantly associated with the child's serum levels of IgE and IL‐2R, but it was negatively associated with the maternal nickel exposure.ConclusionsThis is the first study showing the potential immunological effects of maternal nickel exposure in their children at an early developmental stage.
The prevalence, antibiotic resistance and multilocus sequence typing of colistin‐resistant bacteria isolated from Penaeus vannamei farms in earthen ponds and HDPE film‐lined ponds in China
Authors: Que Muyi , Cao Weiwei , Zhang Huang , Shi Lei , Ye Lei 
Published: July 2022

AbstractThe aquaculture environment, especially the culture ponds and aquaculture products, is considered to be an important reservoir of colistin resistance genes. However, systematic investigations of colistin resistance in Penaeus vannamei farming in different culture modes are scarce. In this study, a total of 93 non‐duplicated samples were collected from P. vannamei farms in five cities in China from 2019 to 2021. The prevalence, antibiotic resistance and multilocus sequence typing (MLST) of colistin‐resistant bacteria were measured and analysed. The results showed that among the 1601 isolates in P. vannamei and its environmental samples, the pollution of colistin‐resistant bacteria was serious (the overall prevalence was 37.3% and 28.8%, respectively), regardless of the earthen pond or high‐density polyethylene (HDPE) film‐lined pond. Among 533 isolates, the prevalence of mobile colistin resistance (mcr) genes, mcr‐1, was the highest (60%, 320/533), followed by mcr‐4 (1.5%, 8/533), mcr‐8 (0.9%, 5/533), mcr‐10 (0.6%, 3/533) and mcr‐7 (0.4%, 2/533). The prevalence of mcr‐1 in earthen ponds was significantly higher than that in HDPE film‐lined ponds (67.5% vs. 49.1%, p < .001). The dominant strain carrying mcr‐1 was Bacillus spp. (54.1%, 173/320), followed by Enterobacter spp. (8.1%, 26/320), Staphylococcus spp. (6.3%, 20/320) and Aeromonas spp. (5.3%, 17/320). The antibiotic resistance profiles of 173 Bacillus spp. varied among different sampling locations and culture types. These isolates were highly resistant to cefepime, ceftriaxone, trimethoprim‐sulfamethoxazole and ceftiofur (>45%), and multidrug‐resistant isolates were common (62.4%, 108/173). Sequence type (ST) 26 (37/66, 56%) was found to be the most prevalent ST in mcr‐1‐positive Bacillus cereus isolated from the aquaculture environment. In summary, our study pointed out that it is necessary to continuously monitor antibiotic usage and its residues regardless of the pond types, especially with regard to critical drugs such as colistin.
Antigenic epitope screening and functional modification of mannose enhance the efficacy of largemouth bass virus subunit vaccines
Authors: Jia Yi‐Jun , Xia Jun‐Yao , Jiang Fu‐Yi , Li Yang , Chen Guo , Zhu Bin 
Published: July 2022

AbstractMajor capsid protein (MCP) can be used as a subunit vaccine against largemouth bass virus (LMBV). However, subunit vaccines usually have low immunogenicity. Here, to identify the major immunogenicity determinant region of the MCP gene, we truncated the MCP of the LMBV gene into four parts (MCP‐1, MCP‐2, MCP‐3 and MCP‐4). Enzyme‐linked immunosorbent assay (ELISA) was used to identify the antigenicity of these four truncated MCP proteins. Then, the highly antigenic truncated protein was modified with mannose and connected with functionalized single‐walled carbon nanotubes (SWCNTs) as carriers. Largemouth basses were immunized by bath immersion, challenged with LMBV on the 28th day after immunization and evaluated for related immune indicators. The results indicated that the MCP‐2 protein could induce a higher antibody titre than the other truncated MCP proteins. We found that the levels of immune‐related genes (TNF‐α, CD40, IgM, IFNγ and IL‐10) in the spleen and kidney were significantly increased in the MCP‐2 and MCP‐2‐Man groups. ELISA results showed that the antibody content in the serum increased significantly in the MCP‐2 group 7 days post‐vaccination and increased with days in all the vaccinated groups, with the highest observed on the 21st day. Notably, the MCP‐2‐Man vaccine (10 mg L−1) showed durability of immunoprotection efficacy that could protect largemouth basses from LMBV challenge, and the immune protection rate reached 78.94%. These results suggest that MCP‐2 might be the major immunogenicity determinant region of LMBV and that the mannose‐modified MCP‐2 vaccine can induce stronger adaptive immune responses.
Intersectional stigma and developmental competence among youth living with HIV
Authors: Gabbidon Kemesha , Chenneville Tiffany , Earnshaw Valerie , Drake Hunter 
Published: July 2022

AbstractHIV continues to heavily burden vulnerable groups including youth, racial/ethnic minorities, sexual and gender minorities, and those who are socioeconomically disadvantaged. Youth living with HIV (YLWH) experience intersecting stigmas that may produce disruptive effects as they navigate adolescence. Considering the dual roles of development and intersectionality, we produce an integrated framework pulling on the constructs of the Process Person Context Time Model—a developmental framework—and the Stigma and HIV Disparities Model—an intersectional framework—to produce a nuanced examination of the processes, persons, and contexts supporting psychosocial and biological resilience among YLWH. Implications for future directions such as expanding theoretical frameworks to address both the developmental and intersectional challenges experienced by YLWH (and/or living with other stigmatized illnesses) and creating policies and practices that support the health of vulnerable youth are discussed.
Inflammatory complications after hair transplantation: Report of 10 cases
Authors: Saad Sarra , Cavelier‐Balloy Bénédicte , Smadja Jack , Assouly Philippe , Reygagne Pascal 
Published: July 2022

AbstractBackgroundAndrogenetic alopecia (AGA) is a pathology involving the aesthetic prognosis. Hair transplantation is among best treatments. The principle of hair micro‐grafts during AGA consists in taking hair from the non‐androgen‐dependent occipital area to transplant them with their root in the sparse androgen‐dependent areas. Herein, we report 10 cases of the different types of post‐transplant inflammatory complications.Materials and MethodsWe included patients referred to our center by their dermatologists or hair transplant surgeons for inflammatory cicatricial alopecia or hair loss observed after the hair transplant.ResultsTen patients (eight men and two women) were included. These patients represented 0.08% of all consultations in our center. The indication for hair transplantation was AGA in all of our patients. The technique used for the transplant was follicular unit extraction (FUE) in seven cases and follicular unit transplantation (FUT) strip in three cases. None of the patients had pathology of the scalp or an inflammatory dermatosis before the operation. The inflammatory complications found were lichen planopilaris (LPP) in seven cases, erosive pustulosis of the scalp (EPS) in two cases, and superficial folliculitis (SF) in 1 case.ConclusionOur series highlight the rarity of inflammatory complications that occur after a hair transplant. We demonstrate through this work that a hair transplant can trigger inflammatory pathology a few months after the act. We show also, the importance of detecting the rough forms of lichen before an intervention, hence the interest of the systematic dermatoscopic examination during the preoperative consultation.
Key parameters of non‐ablative fractional laser pretreatments for enhanced topical uptake
Authors: Wang Jordan V. , Friedman Paul M. , Johnson Jenny , Konda Adarsh , Keator Linda , Geronemus Roy G. 
Published: July 2022

AbstractBackgroundThe uptake of topical formulations can be enhanced through laser pretreatments. Newer technologies, such as non‐ablative fractional lasers (NAFLs), can target dermal tissues and spare the stratum corneum (SC), which can mitigate common side effects associated with ablative laser treatment.ObjectiveTo discuss the parameters of 2 NAFL pretreatment systems (1440‐nm/1927‐nm diode system or 1550‐nm erbium‐doped glass/1927‐nm thulium system), which can be paired with topicals to improve their cutaneous uptake.Methods and MaterialsThe parameters of the 1440‐nm/1927‐nm diode system and 1550‐nm erbium‐doped glass/1927‐nm thulium system were reviewed, as well as in vivo experiments using both laser systems.ResultsMultiple parameters should be optimized to enhance the uptake of various topical formulations and minimize side effects, including wavelength, spot size, density, pulse duration, thermal properties, and topical formulation. Chosen therapeutic parameters must account for patient‐specific factors, such as treatment indication, therapeutic area, and Fitzpatrick skin type. In vivo experiments have demonstrated that both laser systems are effective in enhancing the uptake of various topical therapies relative to untreated controls.ConclusionIndividualization of laser system parameters increases efficiency and minimizes risk.
Impact of school closure due to the coronavirus disease 2019 pandemic on body mass index in Japanese children: Retrospective longitudinal study
Authors: Nagashima Yuka , Inokuchi Mikako , Yasui Yosuke , Uchida Keiko , Tokumura Mitsuaki , Hasegawa Tomonobu 
Published: July 2022

AimDuring the coronavirus disease 2019 pandemic, the governments of many countries responded to high levels of infection with lockdowns. As a result, some children were reported to experience weight gain. The aim of the present study was to examine the impact of school closures on body mass index (BMI) in Japanese children.MethodsThis was a retrospective study of students enrolled in the participating schools (6‐ to 11‐year‐old elementary school students and 12‐ to 14‐year‐old junior high school students) between 2015 and 2020. Using school health check‐up data, annual changes in the BMI standard deviation score (ΔBMI‐SDS) were calculated. We compared ΔBMI‐SDS in 2019–2020 with the corresponding control years.Results19 565 children with complete data were included in the analysis. Median ΔBMI‐SDS in 2019–2020 were 0.24–0.35 in elementary school boys, 0.10–0.13 in junior high school boys, −0.02 to 0.15 in elementary school girls and −0.14 to −0.10 in junior high school girls. In comparison with every control year, ΔBMI‐SDS in 2019–2020 were significantly higher in elementary school boys (control years: −0.07 to 0.14) and junior high school boys (control years: −0.04 to 0.06), and significantly lower in junior high school girls (control years: −0.06 to 0.09).ConclusionBMI‐SDS increased significantly in elementary and junior high school boys, but decreased significantly in junior high school girls. The pandemic appears to have had an impact on Japanese children that was different from other countries.
Efficacy of extracts of mango residues loaded in chitosan nanoparticles and their nanocoatings on in vitro and in vivo postharvest fungal
Authors: Istúriz‐Zapata María Alejandra , Correa‐Pacheco Zormy Nacary , Bautista‐Baños Silvia , Acosta‐Rodríguez José Luis , Hernández‐López Mónica , Barrera‐Necha Laura Leticia 
Published: July 2022

AbstractThe antifungal efficacy of ethanolic extracts of peels and seeds of mango (cvs. Ataulfo, Manila, Kent and Creole) at concentrations of 2.5, 5, 7.5 and 10% w/v were assessed. Nanostructured coatings based on chitosan nanoparticles (CNPs), chitosan‐peel extracts nanoparticles (CPNP) and chitosan‐seed extracts nanoparticles (CSNP) were evaluated in the four mango cultivars. The volatile composition of the extract was measured by GC/ME. For the nanoparticles (NP), dynamic light scattering (DLS), Zeta potential and Fourier‐transform infrared spectroscopy (FTIR) of CNP, CPNP and CSNP, and the in vitro and in situ effects of the nanocoatings on various postharvest phytopathogens were also tested. Of the 42 volatile found, 11 exhibited antimicrobial activity. Among these, α‐pinene was present in all cvs and Creole. The average NP sizes were 5 ± 2.76 nm for CNP, 4.123 ± 1.23 nm for CPNP and 3.11 ± 1.06 nm for CSNP with Zeta potentials of −1.94 mV, −2.26 mV and − 4.53 mV respectively. The peel extracts were more efficient at reducing mycelial growth. The most sensitive fungi were Colletotrichum asianum and Talaromyces variabilis. The CPNP completely inhibited the in vitro growth of C. asianum, Fusarium solani, Lasiodiplodia theobromae, Neofusicoccum oculatum, Pestalotiopsis mangiferae and T. variabilis. The lowest disease incidence was 20% for the cv. Manila with the nanocoating of CSNP, while in cv Kent, an infection reduction of 50% was achieved with the nanocoating of CPNP. Lower disease severity was with both nanocoatings in cv. Kent. The use of Nanocoatings from mango residues could be an excellent option as a natural antifungal agent.