bluuebunny/crossref_metadata_2025_split huggingface dataset:
RBM47 is a novel immunotherapeutic target and prognostic biomarker in gliomas
Authors: Wei Wei , Cao Yongfu , Lu Xin , Wang Long , Li Jianbin , Deng Guojun , Li Donghai , Xiao Limin 
Published: January 2025

AbstractThe role of RBM47, an RNA-binding protein, in shaping the immune landscape of gliomas and tumor immune responses is yet to be fully studied. Therefore, a comprehensive investigation into the immunomodulatory roles of RBM47 in gliomas was conducted, leveraging gene expression data from multi-omic datasets. The prognosis of patients with gliomas considering RBM47 was elucidated using bioinformatics methods and clinical data, with results validated using immunohistochemistry and immunofluorescence analyses. The expression of RBM47 in gliomas was higher than that in normal tissues and was positively correlated with the World Health Organization tumor grade. Increased RBM47 expression is associated with poor prognosis in patients with glioma, serving as an independent predictor of overall survival. The nomogram combining RBM47 expression levels with clinical prognostic factors demonstrated strong predictive accuracy, achieving a C-index of up to 0.863 in both TCGA training and CGGA validation groups. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Variation Analysis indicated that RBM47 is closely related to immunity and inflammation. Single-cell sequencing and immunofluorescence assays confirmed the enrichment of RBM47 in CD163 + macrophages. Therefore, RBM47 plays a vital role in the immune microenvironment of gliomas and may be a potential immunotherapy target.
Elevations in D-dimer levels in patients with Plasmodium infections: a systematic review and meta-analysis
Authors: Sukati Suriyan , Kotepui Kwuntida Uthaisar , Masangkay Frederick Ramirez , Tseng Ching-Ping , Mahittikorn Aongart , Anabire Nsoh Godwin , Wilairatana Polrat , Wangdi Kinley , Majima Hideyuki J , Suwannatrai Apiporn Thinkhamrop , Klangbud Wiyada Kwanhian , Mala Wanida , Rattanatham Rujikorn , Kotepui Manas 
Published: January 2025

AbstractD-dimer, a byproduct of cross-linked fibrin degradation, arises during the fibrinolysis process, breaking down blood clots in circulation. This systematic review and meta-analysis aimed to synthesize evidence of D-dimer alteration in people with malaria, including variations in disease severity. The systematic review was registered in PROSPERO with registration number CRD42024528245. Searches were performed in EMBASE, Scopus, MEDLINE, PubMed, Nursing & Allied Health Premium, and Journals@Ovid on March 25, 2024, to identify original studies that reported D-dimer in patients with Plasmodium infections. The methodological quality of the included studies was assessed using the Joanna Briggs Institute critical appraisal tools. Thematic synthesis and meta-analysis were carried out to synthesize the findings of the included studies. A total of 24 studies were included in the review out of 1,115 records identified. According to the evaluated studies, patients with Plasmodium infections had higher D-dimer levels. A meta-analytic evaluation of D-dimer levels between patients with and without Plasmodium infections revealed a significant elevation of D-dimer in patients with infection, with high heterogeneity (SMD = 2.11, 95% CI = 0.59; 3.64, P = 0.007, I² = 98%, 6 studies, 1,418 participants, random-effects model). However, no significant alterations in D-dimer levels were observed following the comparison between patients with severe and uncomplicated malaria, also with high heterogeneity (SMD = 2.54, 95% CI = -1.60; 6.68, P = 0.23, I² = 99%, 3 studies, 595 participants). The findings suggested that malaria patients have significantly higher D-dimer levels compared to non-malarial individuals. However, there was no significant difference in D-dimer levels between severe and uncomplicated malaria cases. These results highlight the potential of D-dimer as a biomarker for Plasmodium infections, but its clinical utility requires further validation. Future studies should prioritize standardizing D-dimer measurement methods, including assay types, threshold values, and sample types, to ensure consistent and reliable application in clinical settings. Additionally, large, multicentric cohorts are needed to establish robust guidelines for incorporating D-dimer into malaria management practices. Further research should also explore the role of D-dimer in the pathogenesis of Plasmodium infections to deepen our understanding of their clinical significance.
Spectral energy distribution modelling of broad emission line quasars: From X-ray to radio wavelengths
Authors: Chakraborty Avinanda , Kundu Maitreya , Chatterjee Suchetana , Panda Swayamtrupta , Sar Arijit , Jaison Sandra , Chatterjee Ritaban 
Published: January 2025

Aims. We study differences in the physical properties of quasar host galaxies using an optically selected sample of radio-loud (RL) and radio-quiet quasars (in the redshift range 0.15 ≤ z ≤ 1.9) that we have further cross-matched with the VLA-FIRST survey catalogue. The sources in our sample have broad Hβ and Mg II emission lines (1000 km/s < FWHM < 15 000 km/s) with a sub-sample of high broad-line quasars (FWHM > 15 000 km/s). We constructed the broad-band spectral energy distribution (SED) of our broad-line quasars using multi-wavelength archival data and targeted observations with the AstroSat telescope.
Methods. We used the state-of-the-art SED modelling code CIGALE v2022.0 to model the SEDs and determine the best-fit physical parameters of the quasar host galaxies; namely, their star formation rate (SFR), main-sequence stellar mass, luminosity absorbed by dust, e-folding time, and stellar population age.
Results. We find that the emission from the host galaxy of our sources is between 20% and 35% of the total luminosity, as they are mostly dominated by central quasars. Using the best-fit estimates, we reconstructed the optical spectra of our quasars, which show remarkable agreement in reproducing the observed SDSS spectra of the same sources. We plot the main-sequence relation for our quasars and note that they are significantly away from the main sequence of star-forming galaxies. Further, the main-sequence relation shows a bimodality for our RL quasars, indicating populations segregated by Eddington ratios.
Conclusions. We conclude that RL quasars in our sample with lower Eddington ratios tend to have substantially lower SFRs for similar stellar mass. Our analyses thus provide a completely independent route to studying the host galaxies of quasars and addressing the radio dichotomy problem from the host galaxy angle.
Methane precipitation in ice giant atmospheres
Authors: Toledo D. , Rannou P. , Irwin P. , de Batz de Trenquelléon B. , Roman M. , Apestigue V. , Arruego I. , Yela M. 
Published: January 2025

Context. Voyager-2 radio occultation measurements have revealed changes in the atmospheric refractivity within a 2–4 km layer near the 1.2-bar level in Uranus and the 1.6-bar level in Neptune. These changes were attributed to the presence of a methane cloud, consistent with the observation that methane concentration decreases with altitude above these levels, closely following the saturation vapor pressure. However, no clear spectral signatures of such a cloud have been detected thus far in the spectra acquired from both planets.
Aims. We examine methane cloud properties in the atmospheres of the ice giants, including vertical ice distribution, droplet radius, precipitation rates, timescales, and total opacity, employing microphysical simulations under different scenarios.
Methods. We used a one-dimensional (1D) cloud microphysical model to simulate the formation of methane clouds in the ice giants. The simulations include the processes of nucleation, condensation, coagulation, evaporation, and precipitation, with vertical mixing simulated using an eddy-diffusion profile (Keddy).
Results. Our simulations show cloud bases close to 1.24 bars in Uranus and 1.64 bars in Neptune, with droplets up to 100 µm causing high settling velocities and precipitation rates (∼370 mm per Earth year). The high settling velocities limit the total cloud opacity, yielding values at 0.8 µm of ∼0.19 for Uranus and ∼0.35 for Neptune, using Keddy = 0.5 m2 s−1 and a deep methane mole fraction (μCH4) of 0.04. In addition, lower Keddy or μCH4 values result in smaller opacities. Methane supersaturation is promptly removed by condensation, controlling the decline in μCH4 with altitude in the troposphere. However, the high settling velocities prevent the formation of a permanent thick cloud. Stratospheric hazes made of ethane or acetylene ice are expected to evaporate completely before reaching the methane condensation level. Since hazes are required for methane heterogeneous nucleation, this suggests either a change in the solid phase properties of the haze particles, inhibiting evaporation, or the presence of photochemical hazes.
Short-term and long-term fluoride stress induce differential molecular and transcriptional regulation and variable ranges of fluoride tolerance in two indica rice (Oryza sativa) varieties
Authors: Singh Ankur , Banerjee Aditya , Roychoudhury Aryadeep 
Published: January 2025

The aim of this study was to decipher the reprogramming of protective machineries and sulfur metabolism, as responses to time-dependent effect of fluoride stress for 10 and 20 days in two indica rice (Oryza sativa) varieties. Unregulated accumulation of fluoride via chloride channels (CLC1 and CLC2) in 10-day-old (cv. Khitish) and 20-day-old (cv. MTU1010) seedlings caused higher accumulation of H2O2 and superoxide anion that eventually incited chlorophyll loss and electrolyte leakage, along with the formation of malondialdehyde and methylglyoxal. Higher fluoride accumulation also enhanced lipoxygenase and NADPH oxidase activities, which further aggravated the oxidative damages. However, for stressed 20-day-old Khitish and 10 day-old MTU1010 seedlings, plant growth was maintained with lesser oxidative damages due to upregulated expression of H+-ATPase and FEX along with the elevated level of cysteine and H2S, which could be linked with higher activity of ATP-S, OASTL, and DES. The activity of the enzymatic antioxidants (superoxide dismutase, catalase, ascorbate peroxidase, guaiacol peroxidase, and glutathione peroxidase) and level of non-enzymatic antioxidants (anthocyanins and flavonoids) were also enhanced that strengthened the antioxidative potential of the seedlings. Our work demonstrated that differential reprogramming of the protective metabolites and sulfur assimilation pathways is responsible for the differential pattern of adaptive strategies against fluoride stress in the two indica rice varieties, with Khitish exhibiting tolerance against long-term fluoride stress, whilst MTU1010 showing high susceptibility to the same.
The New Haven School
Authors: Derrig Ríán 
Published: January 2025

Abstract
This book is an intellectual history of the ‘New Haven School’, a school of legal theory and practice associated with Yale Law School in the city of New Haven. New Haven School ‘policy-oriented jurisprudence’—so-called for its emphasis on using law to pursue acknowledged policy aims—was developed from the 1940s by Harold Lasswell, a central figure of twentieth-century American political science, and Myres McDougal, a prominent international lawyer. The book argues that the New Haven School style of argument was representative of mid-century American international law. Through the biographies and scholarship of Lasswell, McDougal, and New Haven School members, and using previously unexploited archival materials, the book explores how this body of legal theory was shaped and how it influenced the legal arguments made by McDougal and other members of the school in support of Cold War anti-communist policy positions and legal practice of the United States. The book shows that the New Haven School represented a specific anti-formalism and a collection of methods that characterized how American scholars and lawyers practised international law in the middle of the twentieth century, and still do today.
The Psychological Age
Authors: Derrig Ríán 
Published: January 2025

Abstract
This chapter uses archival sources to develop an intellectual biography of Harold Lasswell’s life before he met Myres McDougal in 1935 and began to develop their ‘policy-oriented jurisprudence’. The chapter recounts formative experiences of Lasswell’s childhood in small, early twentieth-century Illinois towns, including his interactions with Progressive Era politicians. Lasswell’s studies at the University of Chicago are examined. The chapter reconstructs his contact with historically prominent figures in 1920s Geneva at the League of Nations, in London amongst the Fabian Society, in Freudian psychoanalytic circles in Vienna, and in avant-garde psychoanalytic circles in Berlin. Lasswell’s efforts to pursue research on psychoanalysis and politics in the 1930s United States are described, as are the 1950s FBI investigations into his associations with communism. The chapter argues that Lasswell’s experiences and scholarship in this period heavily influenced the policy-oriented jurisprudence he would later develop with McDougal.
Teaching American International Law
Authors: Derrig Ríán 
Published: January 2025

Abstract
This chapter uses unpublished teaching materials to reconstruct the legal theory that Harold Lasswell and Myres McDougal taught in their Law, Science and Policy seminars at Yale Law School from the 1940s. The chapter connects the core tenets of their ‘policy-oriented jurisprudence’ to legal arguments in support of Cold War anti-communist policies of the US State Department that made the New Haven School famous and controversial. The psychoanalytic and anthropological premises of this theory are emphasized, as is its theorization of connections between the personal characters of people and constitutional orders. Using examples from the laws of war and in war, as well as international human rights law, the chapter argues that this understanding of how personal value commitments related to legal and political order was central to New Haven School legal arguments, which were representative of the broader field of American international law.
The School
Authors: Derrig Ríán 
Published: January 2025

Abstract
This chapter reconstructs the web of former students who associated themselves with what they called the ‘New Haven School’ and used the legal theory developed by Harold Lasswell and Myres McDougal. It examines McDougal’s practice of co-authoring his most prominent legal arguments with former students and draws on debates between those co-authors and in the wider field of international law to explore how the anti-formalist style of New Haven School arguments was understood to challenge an ideal of the autonomy of international law from politics. McDougal’s arguments at the Vienna Conference on the Law of Treaties and for the United States in the 1986 ICJ case Nicaragua v United States are used to illustrate the perceived political consequences of his anti-formalism and to argue that it became representative of American international law more broadly.
Introduction
Authors: Derrig Ríán 
Published: January 2025

Abstract
This chapter introduces the book. It explains that as a book about the New Haven School—the mid-century legal theory developed by Harold Lasswell and Myres McDougal at Yale Law School in the city of New Haven—it is also inevitably a book about American international law. The chapter describes how the New Haven School practiced and represented an effective articulation of a style of arguing about and using law that characterized American international law at mid-century, and which still does so today. The chapter explains methodological premises adopted in writing the book, and concludes by introducing the structure of the book as a whole and of each subsequent chapter.
Explanatory Solutions to Skeptical Problems
Authors: McCain Kevin 
Published: January 2025

Abstract
In Appearance & Explanation, Kevin McCain and Luca Moretti developed “Phenomenal Explanationism” (PE). PE is a theory of epistemic justification that combines an explanationist theory of evidential support with an appearance-based/phenomenal conception of evidence. According to PE, epistemic justification is a matter of what best explains our evidence, which ultimately consists of appearances. In Appearance & Explanation it was argued that PE is a complete internalist theory of epistemic justification that delivers on the promises of other appearance-based theories while avoiding their pitfalls. One of the promises of PE is that it provides a satisfactory response to skepticism. However, in Appearance & Explanation only PE’s response to external world skepticism was discussed, and that discussion of the issue was limited. In Explanatory Solutions to Skeptical Problems the discussion of PE’s response to external world skepticism is greatly expanded. This isn’t all though. In Explanatory Solutions to Skeptical Problems readers will find that PE also offers solutions to a host of other perennial skeptical problems, including the problem of the criterion, the regress of justification, memory skepticism, and inductive skepticism. The promise PE displays in responding to these problems makes it plain that it is a viable theory of epistemic justification worthy of careful consideration and that accepting internalism more generally doesn’t leave one without reasonable responses to skeptical problems.
Phenomenal Explanationism Revisited Part II
Authors: McCain Kevin 
Published: January 2025

Abstract
This chapter completes discussion of Phenomenal Explanationism (PE) as a theory of epistemic justification. In particular, the explanationist account of evidential fit is formulated and various finer points are discussed such as the relevant notion of explanation and what it takes for an explanation to be the best. Once the details of PE are firmly in hand the chapter turns toward an explication of how PE applies to various kinds of justification. Specifically, the chapter discusses a number of cases of perceptual, memorial, testimonial, introspective, inferential, and a priori justification and how PE yields the intuitively correct results in each case.
The Cartesian Problem
Authors: McCain Kevin 
Published: January 2025

Abstract
This chapter begins by getting clear on the nature of the skeptical argument for external world skepticism. The relationship between skeptical arguments that rely on closure principles and skeptical arguments that rely on underdetermination principles is explored. The chapter shows how Phenomenal Explanationism (PE) offers a unified response to both forms of the skeptical argument. The chapter then argues that overly simple skeptical hypotheses can be dismissed because they cannot match the explanatory power of our common-sense view of the world. The chapter also includes an argument for thinking that the explanation offered by our common-sense view of the world is superior to all of the relevant skeptical competitors (the skeptical competitors that are sufficiently sophisticated to avoid the problem with overly simple skeptical hypotheses). It is for this reason that our common-sense view of the world is justified, and skeptical arguments are unsound.
Memory Problems
Authors: McCain Kevin 
Published: January 2025

Abstract
This chapter explains Phenomenal Explanationism’s (PE) responses to two forms of memory skepticism: skepticism about the past and skepticism concerning the reliability of the faculty of memory itself. Concerning the first problem, the chapter contends that of the many (perhaps infinite) ages that the world could be only a small portion of those would actually amount to a genuine skeptical threat. Once it is made clear that the non-skeptical age range for the world is vastly larger than the skeptical one, it appears that we have good reason to reject skepticism about the past. With respect to the second problem, it is made clear that skeptical attacks on memory are limited in key ways. Once these limitations are recognized, PE provides good reason to think that the faculty of memory is reliable.
Among Other Things, a Theological Solution to the Fermi Paradox
Authors: Sportiello Daniel John 
Published: January 2025

Abstract
This essay addresses a serious question in theistic bioethics—what those of faith ought to make of transhumanism. In it, I argue for two theses: (1) Humanity—having slain Pestilence, War, and Famine—will slay Death as well. (In other words, the transhumanists are descriptively right.) (2) It is not death that really torments us. (In other words, the transhumanists are normatively wrong.) In doing so, I’ll suggest a theological solution to the Fermi Paradox: maybe we have not encountered any other technological civilizations because, while intelligent animals are fairly common in our galaxy, none of the others are driven by the restlessness that would drive us to sail the stars. In other words, maybe none of the others are fallen.
Patient activation improves with a multi-component personalized mHealth intervention in older patients at risk of cardiovascular disease: a pilot randomized controlled trial
Authors: Candelaria Dion , Cacciata Marysol , Serafica Reimund , Reyes Andrew Thomas , Lee Jung-Ah , Hildebrand Janett A , Sta. Maria Axel , Strömberg Anna , Evangelista Lorraine S 
Published: January 2025

Abstract

Aims
This study aimed to determine the effect of a multi-component mHealth intervention on patient activation and examine its predictors among older adults at risk of cardiovascular disease (CVD).

Methods and results
This pilot randomized controlled trial compared two groups: Get FIT (control), who received healthy lifestyle counselling from a licensed health coach, a mHealth app (MyFitnessPal) with push alerts, and an activity tracker, and Get FIT + (intervention), who received the same interventions and had personalized text messages with 3- and 6-month follow-up periods. Patient activation was measured using the 13-item Patient Activation Measure; higher scores indicated better activation. Linear mixed-effects models were used to investigate between-group changes in outcomes across time. The participants’ (n = 54) mean age was 65.4 ± 6.0 years; 61% were female; and 61% were married. Baseline characteristics were comparable between groups. Significant improvements in mean patient activation scores were observed in the Get FIT + group at 3 months [mean 3.53 points, 95% confidence interval (CI) 0.11, 6.96; P = 0.043] and 6 months (mean 4.37 points, 95% CI 0.91, 7.83; P = 0.014), whereas improvements in the Get FIT group were non-significant. Adjusting for age, gender, education, employment, marital status, social support, smartphone confidence, and self-perceived health, we found that only social support was associated with higher patient activation overall (B = 5.14, 95% CI 1.00, 9.27; P = 0.015).

Conclusion
The findings indicate that personalized text messaging can improve the self-care of older adults at risk of CVD. Findings also emphasize the importance of social support in the success of mHealth interventions for older adults.

Registration
The study is registered in ClinicalTrials.gov (NCT03720327).
Invariance of Elliptic Genus Under Wall-Crossing
Authors: Liu Henry 
Published: January 2025

Abstract
Wall-crossing formulas for various flavors of elliptic genus can be obtained using master spaces. We give a topological criterion which implies that such wall-crossing formulas are trivial. Applications are given for the following: GIT quotients, following Thaddeus; moduli of sheaves, following Mochizuki; and Donaldson–Thomas and Vafa–Witten theory, following Joyce and Tanaka–Thomas, respectively.