bluuebunny/crossref_metadata_2025_split huggingface dataset:
Präklinische Zell- und Tiermodelle zur Untersuchung der
Auswirkungen des Parathormons auf den Zahnhalteapparat
Authors: Marnet Katharina , Schiffmaier Jana , Herrmann Marietta 
Published: May 2022

ZusammenfassungDas Parathormon (PTH) oder das Parathormon verwandte Protein (PTHrP) binden an
den Parathormon Rezeptor Typ 1 (PTH1R) und lösen somit unterschiedliche
biochemische Antworten aus. Der PTH1R gehört zur Familie der G-Protein
gekoppelten Rezeptoren und reguliert die Calciumhomöostase und die
Knochenbildung. Im Zahnhalteapparat sind Mutationen im PTH1R mit
Zahndurchbruchsstörung assoziiert und bringen einen Verlust des
Alveolarknochens mit sich.Durch präklinische in vitro Studien konnte gezeigt werden, dass
PTH einen positiven Einfluss auf die Proliferation und die Differenzierung von
Zellen aus dem parodontalen Ligament hat. Die intermittierende Verabreichung von
PTH in vivo hat in unterschiedlichen Studien einen positiven Einfluss auf
den Alveolarknochenverlust bewirkt, was eine Grundlage für einen
Therapieansatz in dentalen Erkrankungen darstellt. Jedoch sind die
molekularbiologischen Zusammenhänge bei der intermittierenden
Applikation von PTH noch nicht bekannt, weshalb weitere Untersuchungen notwendig
sind.In diesem kurzen Übersichtsartikel werden daher verschiedene Studien
über die Verabreichung von PTH und seine Auswirkungen auf den
Zahnhalteapparat verglichen.
8-Quinolinyl Oxazoline: Ligand Exploration in Enantioselective Ni-Catalyzed Reductive Carbamoyl-Alkylation of Alkene to Access the Chiral Oxindoles
Authors: Wu Xianqing , Chen Yifeng , Luan Baixue , Tang Zaiquan 
Published: May 2022

AbstractChiral ligands play an essential role in transition-metal-catalyzed enantioselective transformations, in which chiral oxazoline-based scaffolds are the privileged chiral ligand. Nevertheless, 8-quinolinyl oxazoline (8-Quinox) ligands are underexplored in transition-metal-catalyzed asymmetric transformations since their development in 1998. Herein, we report an 8-Quinox ligand promoted Ni-catalyzed enantioselective reductive carbamoyl-alkylation of carbamoyl chloride tethered styrene with unactivated alkyl iodide, providing an expedient access to valuable enantioenriched oxindoles in good results.
Zur Umsetzung der Verordnung (EU) 2017/746 vom 5. April 2017 über In-vitro-Diagnostika (IVDR) in medizinischen Laboratorien, insbesondere in der
Ophthalmopathologie
Authors: Auw-Hädrich Claudia , Reinhard Thomas , Hädrich Johannes 
Published: May 2022

ZusammenfassungDie Europäische Kommission hat die Richtlinie 98/79/EG über In-vitro-Diagnostika (IVDD) überarbeitet, um die Sicherheit der Patienten zu verbessern und dem technischen Fortschritt
angemessen Rechnung zu tragen. Mit der neuen Verordnung (EU) 2017/746 vom 5. April 2017 über In-vitro-Diagnostika (IVDR) gelten innerhalb der Europäischen Union hohe Standards für Qualität
und Sicherheit von In-vitro-Diagnostika (IVD). Die IVDR richtet sich in erster Linie an Hersteller und Anbieter von IVD, hat aber auch erhebliche Auswirkungen auf medizinisch-diagnostische
Labore. Ihre Anwendung ist seit dem 26. Mai 2022 verbindlich. Die IVD werden entsprechend ihrer Zweckbestimmung und den damit verbundenen Risiken in 4 Risikoklassen A bis D eingeteilt.
Erstmals werden EU-weit gesetzliche Anforderungen an Produkte aus Eigenherstellung formuliert. Jedes medizinische Labor, das „laborentwickelte Tests“ (LDT) verwendet, oder CE-IVD-Produkte
verändert oder außerhalb der Herstellerangaben einsetzt, wird selbst zum Hersteller und es gilt IVDR-Artikel 5 (5) in vollem Umfang. Herstellung und Verwendung von LDT müssen dann im Rahmen
geeigneter QM-Systeme erfolgen. Die Gesundheitseinrichtung muss bestimmten Vorschriften (Normen) entsprechen, in Deutschland ist hier die Rili-BÄK zu nennen. Die LDT unterliegen den in
Anhang 1 zur IVDR aufgeführten Sicherheits- und Leistungsanforderungen, darunter der Verpflichtung zur Validierung vor erstmaligem Gebrauch, während kommerzielle CE-IVD-Produkte lediglich
verifiziert werden müssen. Verordnung (EU) 2022/112 vom 25. Januar 2022 sieht zwar für einige dieser Anforderungen gestaffelte Übergangsfristen von bis zu 6 Jahren vor, doch es ist zu
erwarten, dass viele Labore von LDT auf kommerzielle CE-IVD-Produkte umstellen werden, weil dies letztlich ressourcenschonender für sie ist. Im vorliegenden Beitrag beschreiben wir die sich
aus der IVDR ergebenden Anforderungen für medizinisch-diagnostische Labore und bieten Lösungskonzepte für deren Umsetzung in kleineren, insbesondere ophthalmopathologischen Laboratorien.
Association of the Transcription Factor 7-Like 2 (TCF7L2) rs7903146
Polymorphism with the Risk of Diabetic Nephropathy: A
Meta-Analysis
Authors: Ning Bobiao , Wang Jie , Li Baohua , Lyu Cuixia 
Published: May 2022

AbstractTranscription factor 7-like 2 (TCF7L2) polymorphism plays an essential role in
the occurrence and development of patients living with diabetes, but the current
conclusions are inconsistent on the relationship between TCF7L2 polymorphism and
the risk of diabetic nephropathy. This meta-analysis aims to explore the exact
association between TCF7L2 rs7903146 locus polymorphism and susceptibility to
diabetic nephropathy. PubMed, Embase, Web of Science, Cochrane Library, China
National Knowledge Infrastructure (CNKI), and China Wanfang databases were
searched for studies on the relationship between single nucleotide polymorphism
at TCF7L2 rs7903146 locus and susceptibility to diabetic nephropathy until
January 10, 2022. The data were analyzed by Stata 15.0 software. A total of 7
articles were included, covering 1443 patients with diabetic nephropathy and
2129 diabetic non-nephropathy patients. The results showed that allele C at
TCF7L2 rs7903146 locus, compared to allele T, the pooled odds ratio
(OR)=0.69 (95% CI: 0.56–0.85, p≤0.05). In the
dominant gene inheritance model, recessive gene inheritance model, homozygous
genetic model, and heterozygous genetic model, the pooled OR was 0.47
(95% CI: 0.36–0.61), 0.63 (95% CI: 0.54–0.73),
0.39 (95% CI: 0.29–0.51), and 0.59 (95% CI:
0.45–0.78), respectively, and the differences were statistically
significant. In conclusion, TCF7L2 rs7903146 polymorphism is associated with
susceptibility to diabetic nephropathy. Allele T and genotype TT can increase
the risk of diabetic nephropathy.
Copillar[5]arene Chemistry: Synthesis and Applications
Authors: Vincent Stéphane P. , Chen Wenzhang 
Published: May 2022

AbstractResearch on pillar[n]arenes has witnessed a very quick expansion. This emerging class of functionalized macrocyclic oligoarenes not only offers host–guest properties due to the presence of the central cavity, but also presents a wide variety of covalent functionalization possibilities. This short review focuses on copillararenes, a subfamily of pillar[n]arenes. In copillararenes, at least one of the hydroquinone units bears different functional groups compared to the others. After having defined the particular features of copillararenes, this short review compares the different synthetic strategies allowing their construction. Some key applications and future perspectives are also described. 1	Introduction2	General Features of Pillar[5]arenes3	Synthesis of Functionalized Copillar[4+1]arenes4	Concluding Remarks
Tranexamic Acid and Its Potential Anti-Inflammatory Effect: A Systematic Review
Authors: Okholm Søren Hauge , Krog Jan , Hvas Anne-Mette 
Published: May 2022

AbstractTranexamic acid (TXA) is an antifibrinolytic drug primarily used for reducing blood loss in patients with major bleedings. Animal and cell studies have shown that TXA might modulate the inflammatory response by either enhancing or inhibiting cytokine levels. Furthermore, recent human studies have found altered inflammatory biomarkers in patients receiving TXA when compared with patients who did not receive TXA. In this systematic review we investigated the effect of TXA on inflammatory biomarkers in different patient groups. A systematic literature search was conducted on the databases PubMed and Embase to identify all original articles that investigated inflammatory biomarkers in patients receiving TXA and compared them to a relevant control group. The review was performed according to the PRISMA guidelines, and the literature search was performed on November 29, 2021. Thirty-three studies were included, among which 14 studies compared patients receiving TXA with patients getting no medication, another 14 studies investigated different dosing regimens of TXA, and finally five studies examined the administration form of TXA. The present review suggests that TXA has an anti-inflammatory effect in patients undergoing orthopaedic surgery illustrated by decreased levels of C-reactive protein and interleukin-6 in patients receiving TXA compared with patients receiving no or lower doses of TXA. However, the anti-inflammatory effect was not found in patients undergoing cardiac surgery, pediatric craniosynostosis patients, or in rheumatoid arthritis patients. The inflammatory response was not affected by administration form of TXA (oral, intravenous, or topical). In conclusion, an anti-inflammatory effect of TXA was consistently found among orthopaedic patients only.
Year in Review: Synopsis of Selected Articles in Neuroanesthesia and Neurocritical Care from 2021
Authors: Shao Evan , Hasanaly Nahemah , Venkatraghavan Lashmi 
Published: May 2022

AbstractThis review is a synopsis of selected articles from neuroscience, neuroanesthesia, and neurocritical care from 2021 (January–December 2021). The journals reviewed include anesthesia journals, critical care medicine journals, neurology, and neurosurgical journals as well as high-impact medical journals such as the Lancet, Journal of American Medical Association, New England Journal of Medicine, and Stroke. This summary of important articles will serve to update the knowledge of anesthesiologists and other perioperative physicians who provide care to neurosurgical and neurocritical care patients. In addition, some of the important narrative reviews that are of interest to neuroanesthesiologists are also listed.
Assessing timber trade middlemen for development policy actions: a case study in the Caraga region, Philippines
Authors: Balanay Raquel M. , Reyes Shiela G. , Bongolan Rodrigo L. , Cutao Jaime M. , Casinginan Ronie C. , Omboy Andrew V. 
Published: May 2022

AbstractThe timber trade middlemen are examined in this work to understand their functions, work conditions and work outcomes in the Caraga Region (Philippines) for development insights. Investigative practice and comparative observation were the approaches used to assess these middlemen. The results exhibit the essential role of the timber trade middlemen from log cutting to log delivery and in the regularity of timber trade operations across Caraga Region. Merchant middlemen, agent middlemen and service providers are the three general middlemen types observed. The service providers have the largest number and composition with six subtypes. Further results show that the purchase order holders (merchant middlemen) can profit largely (more than 20%) from the buy and sell of logs. The timber trade middlemen’s work conditions have issues with personal security, occupational safety, price uncertainty and transparency. They have been involved “incognito” in timber trade operations, rendering some of them vulnerable and less protected in the timber supply chain. Policy actions to enhance transparency and recognize properly these middlemen for the safe conduct of their businesses, for further skills development, for their organization in the timber industry, and for incentivizing their services properly are recommended for the sustainable development of the timber supply chain in Caraga Region.
Soft hearts and hard souls
Authors: Díaz-Vera Javier E. 
Published: May 2022

AbstractOne of the most fundamental claims of the Cognitive Theory of Metaphor is the direction of mapping from concrete to abstract. The pervasiveness of this path of semantic change has been widely accepted among researchers interested in the study of the history and development of emotional expressions. Whereas most studies focus on the analysis of one specific target domain (i.e., one emotion or one family of emotions), less attention has been paid to the reconstruction and analysis of the set of diachronic changes that affected one single source domain. Within this framework, in this paper I have used data extracted from standard Old English dictionaries and thesauri, in order to propose a complete analysis of the set of Old English adjectives for different textural properties of physical objects (such as roughness, smoothness, softness and hardness). I am especially interested in the reconstruction and analysis of the paths of semantic change (from concrete to abstract) illustrated by this section of the Old English vocabulary. Broadly speaking, apart from the original senses for physical texture, these adjectives developed secondary meanings in the fields of feelings and emotions, which I have classified into three categories:physical sensations(such as weakness and pleasantness),sensorial sensations(such as auditive, visual or gustative sensations) andemotional sensations(such as grief, anger, compassion and empathy). Furthermore, the resulting figurative meanings (which I have analysed in terms of metonymic, synaesthetic and metaphoric extensions) can also be grouped into positive and negative sensations. The present paper supports the idea that the origin of our understanding of abstract concepts is deeply rooted in our physical experiences. This is indeed a conceptual pattern showed by the diachronic evolution of Old English adjectives for texture. This paper concludes with some remarks on the social and cultural changes that prompted some of these semantic changes, paying special attention to the Christianization of Anglo-Saxon England and the introduction of Christian values.
Recurrent gestures throughout bodies, languages, and cultural practices
Authors: Harrison Simon , Ladewig Silva H. 
Published: May 2022

Abstract
In gesture studies, the adjective ‘recurrent’ has developed to distinguish a range of semiotic and conceptual
phenomena concerning the nature of meaningful bodily movements. This article begins with a brief and recent history of recurrent
gesture studies. We raise ongoing debates concerning the position of recurrent gestures on the so-called Kendon’s continuum, the
relation between gestures and practical actions, and the interplay between gesture’s cultural specificity and universality. A
selection of findings from previous research on recurrent gestures then acquaints readers with characteristics of these gestures:
their form-function pairings and context-variation, linguistic organization and multimodal constructions, and community-specific
typologies (from cultural, situational, as well as individual perspectives). Proposing to help build recurrent gesture theory, the
paper then recognizes that recurrency goes hand-in-hand with diversity – both in the ways these gestures exist
for members of a community and their role in the styles, habits, and creations of individuals.
Photoacoustic inversion formulas using mixed data on finite time intervals*
Authors: Dreier Florian , Haltmeier Markus 
Published: May 2022

Abstract
We study the inverse source problem in photoacoustic tomography (PAT) for mixed data, which denote a weighted linear combination of the acoustic pressure and its normal derivative on an observation surface. We consider in particular the case where the data are only available on finite time intervals, which accounts for real-world usage of PAT where data are only feasible within a certain time interval. Extending our previous work, we derive explicit formulas up to a smoothing integral on convex domains with a smooth boundary, yielding exact reconstruction for circular or elliptical domains. We also present numerical reconstructions of our new exact inversion formulas on finite time intervals and compare them with the reconstructions of our previous formulas for unlimited time wave measurements.
Control of matter-wave solitons using an accelerating atomic mirror
Authors: Xiong Wei , Gao Peng , Yang Zhan-Ying , Yang Wen-Li 
Published: May 2022

Abstract
We present a possible way to control matter-wave solitons, which is through the collision between solitons and an accelerating atomic mirror. The acceleration of the mirror has a nontrivial effect on the dynamical characters of the reflected solitons. In the one-dimensional Bose–Einstein condensates, when the acceleration of the mirror has the identical direction with the initial soliton’s velocity, the soliton will diffuse after collision; in the contrasting case, the soliton will shrink and then diffuse. We quantitatively explain the above dynamical phenomena by analyzing the atoms’ movement in the soliton, and demonstrate that the method can generate a similar effect to the phase imprinting technology. Moreover, considering the dipolar effect between atoms, this approach can be used for the generation and control of breathing solitons.
Phonon-drag thermopower and thermoelectric performance of MoS2 monolayer in quantizing magnetic field
Authors: Phuc Huynh V , Kubakaddi S S , Dinh Le , Bich Tran N , Hieu Nguyen N 
Published: May 2022

Abstract
We present a theory of phonon-drag thermopower,

S

x
x

g

, in MoS2 monolayer at a low-temperature regime in the presence of a quantizing magnetic field B. Our calculations for

S

x
x

g

consider the electron–acoustic phonon interaction via deformation potential (DP) and piezoelectric (PE) couplings for longitudinal (LA) and transverse (TA) phonon modes. The unscreened TA-DP is found to dominate

S

x
x

g

over other mechanisms. The

S

x
x

g

is found to oscillate with the magnetic field where the lifting effect of the valley and spin degeneracies in MoS2 monolayer has been clearly observed. An enhanced

S

x
x

g

with a peak value of

∼

1

mV K−1 at about T = 10 K is predicted, which is closer to the zero field experimental observation. In the Bloch–Grüneisen regime the temperature dependence of

S

x
x

g

gives the power-law

S

x
x

g

∝

T

δ
e

, where δ

e
varies marginally around 3 and 5 for unscreened and screened couplings, respectively. In addition,

S

x
x

g

is smaller for larger electron density n

e
. The power factor PF is found to increase with temperature T, decrease with n

e
, and oscillate with B. The prediction of an increase of thermal conductivity with temperature and the magnetic field is responsible for the limit of the figure of merit (ZT). At a particular magnetic field and temperature, ZT can be maximized by optimizing electron density. By fixing

n
e

=

10

12

cm−2, the highest ZT is found to be 0.57 at T = 5.8 K and B = 12.1 T. Our findings are compared with those in graphene and MoS2 for the zero-magnetic field.
Validation of a fast and traceable radiographic scale calibration of dimensional computed tomography
Authors: Neuschaefer-Rube Ulrich , Illemann Jens , Sturm Matthias , Bircher Benjamin A , Meli Felix , Bellon Carsten , Evsevleev Sergei 
Published: May 2022

Abstract
A fast and highly precise method of determining the geometrical scale factor of computed tomography (CT) measurements has been validated successfully by Bundesanstalt für Materialforschung und -prüfung (BAM), the Federal Institute of Metrology (METAS) and Physikalisch-Technische Bundesanstalt (PTB) within the scope of AdvanCT (Advanced Computed Tomography for dimensional and surface measurements in industry), a project funded in the European Metrology Programme for Innovation and Research (EMPIR). The method has been developed by PTB and requires only two radiographic images of a calibrated thin 2D standard (hole grid standard) from two opposite directions. The mean grid distance is determined from both radiographs. From this and with the help of the calibration result, the radiographic scale and therefore the voxel size is determined. The procedure takes only a few minutes and avoids a time-consuming CT scan. To validate the method, the voxel sizes determined via this method were compared with voxel sizes determined from CT scans of calibrated objects. Relative deviations between the voxel sizes in the range of 10−5 were achieved with minimal effort using cone-beam CT systems at moderate magnifications.
AuPd nanoparticles functionalized core–shell Co3O4/ZnO@ZnO for ultra-sensitive toluene detection
Authors: Wang Ziyan , Liu Hongyan , Shao Junkai , Li Zhenhua , Zhang Hao , Sun Caixuan , Pan Guofeng , Yang Xueli 
Published: May 2022

Abstract
In this work, core–shell AuPd nanoparticles (NPs) sensitized Co3O4/ZnO@ZnO ellipsoid nanoparticles was successfully synthesized via a simple liquid phase synthesis method. SEM and TEM characterization results showed that the as-prepared samples have core–shell ellipsoid morphology and the size of the nanoparticles were uniform. Systematic gas sensing characterization was carried out to obtain the gas sensing property of AuPd NPs decorated Co3O4/ZnO@ZnO. It was found that the gas sensing property could be significantly enhanced after noble metal decoration with Au, Pd and AuPd NPs, respectively. The optimal gas sensing performance was achieved by AuPd NPs functionalized Co3O4/ZnO@ZnO based gas sensor. The maximum response reached 256–100 ppm toluene at 250 °C, which is 50 °C lower than pure ZnO. The detection limit of AuPd functionalized Co3O4/ZnO@ZnO was as low as 100 ppb. The enhanced sensing mechanism was mainly attributed to the synergistic effect of Au and Pd, which was detailly discussed in gas sensing mechanism part.
Plasma electron acceleration in a non-resonant microwave heating scheme below the electron cyclotron frequency
Authors: Köhn-Seemann A , Birkenmeier G , Diez P , Holzhauer E , Merli S , Ramisch M , Sichardt G , Stroth U 
Published: May 2022

Abstract
Microwave heating of over-dense plasmas is routinely achieved in the stellarator TJ-K. In contrast to usually applied heating scenarios in tokamaks or stellarators, an operational regime is described where the heating occurs well below the electron cyclotron frequency but still well above the lower hybrid frequency. Microwave energy is deposited at the so-called O-resonance, accompanied by a small population of high-energy electrons with an energy up to 100 keV. These electrons are responsible for a significant toroidal net current and the occurrence of hard x-rays. Requirements for achieving this heating regime are described together with a novel scheme for plasma-electron acceleration.