bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Skydrol immersion at elevated temperatures on the thermo‐mechanical properties of a high‐Tg anhydride epoxy resin toughened with a hydroxy‐terminated polyester
Authors: Hübsch Jan David , Demleitner Martin , Bard Simon , Berendes Philipp , Altstädt Volker , Mittelstedt Christian 
Published: November 2022

AbstractCurrently, the application of composites in aerospace parts exposed to higher temperatures and in aggressive media is still severely limited. To replace metal alloys, alternative resins systems with suitable long‐term heat resistance are needed. In this study, the effect of the aviation hydraulic fluid Skydrol on the thermal and mechanical properties of a high‐Tg, anhydride‐cured epoxy resin in the unmodified and toughened state at elevated temperature is investigated. An aliphatic polyester diol was selected as an intrinsic toughener and its impact on the thermal, mechanical, and aging properties was determined. Experimental characterization of the aging effects is carried out with dynamic‐mechanical characterization, infrared spectroscopy, and electron dispersion x‐ray spectroscopy. In addition, the fracture toughness and the fatigue crack propagation behavior are determined. Initially, the toughened system shows an improved fracture toughness. Since oxidation is blocked by the Skydrol fluid only thermal degradation takes place as determined by the decrease in glass transition temperature Tg and network density. The thermal degradation leads to a tougher behavior, which is observed in both systems in static and dynamic mode with toughness decreasing with aging time again.
The influence of several nutritional supplements on the rational use of cabozantinib
Authors: Duan Xinyue , Wang Dongjing , Liu Yu , Wang Lei , Wang Xiao , Liu Bin 
Published: November 2022

AbstractTo promote the rational use of cabozantinib (CBZ), this paper studied the influence of several nutritional supplements on the interaction between CBZ and bovine serum albumin (BSA), an appropriate alternative model for human serum albumin (HSA) that is one of the important transporter proteins in plasma, by fluorescence spectroscopy and UV–vis spectroscopy. The results showed that CBZ could quench the fluorescence of BSA via a dynamic–static quenching process, and the six nutritional supplements did not change the quenching mode of BSA by CBZ. However, all of them could reduce the binding constant of the CBZ–BSA system at 293 K and increase the polarity around tryptophan residues. Among them, nicotinamide and vitamin B12 (VB12) had a greater effect on the binding constants of the CBZ–BSA system. In the meantime, the thermodynamic parameters of the CBZ–BSA system were examined, indicating that the interaction of CBZ with BSA was spontaneous and dominated by hydrophobic forces. Further research discovered that the combining of CBZ with BSA was primarily located within Site I of BSA, and the binding distance r was 2.48 nm. Consequently, while taking CBZ, patients should use VB12 and nicotinamide carefully, which may interfere with the transport of drugs.
Translational aspect in peptide drug discovery and development: An emerging therapeutic candidate
Authors: Anand Uttpal , Bandyopadhyay Anustup , Jha Niraj Kumar , Pérez de la Lastra José M. , Dey Abhijit 
Published: November 2022

AbstractIn the last two decades, protein–protein interactions (PPIs) have been used as the main target for drug development. However, with larger or superficial binding sites, it has been extremely difficult to disrupt PPIs with small molecules. On the other hand, intracellular PPIs cannot be targeted by antibodies that cannot penetrate the cell membrane. Peptides that have a combination of conformational rigidity and flexibility can be used to target difficult binding interfaces with appropriate binding affinity and specificity. Since the introduction of insulin nearly a century ago, more than 80 peptide drugs have been approved to treat a variety of diseases. These include deadly diseases such as cancer and human immunodeficiency virus infection. It is also useful against diabetes, chronic pain, and osteoporosis. Today, more research is being done on these drugs as lessons learned from earlier approaches, which are still valid today, complement newer approaches such as peptide display libraries. At the same time, integrated genomics and peptide display libraries are new strategies that open new avenues for peptide drug discovery. The purpose of this review is to examine the problems in elucidating the peptide‐protein recognition mechanism. This is important to develop peptide‐based interventions that interfere with endogenous protein interactions. New approaches are being developed to improve the binding affinity and specificity of existing approaches and to develop peptide agents as potentially useful drugs. We also highlight the key challenges that must be overcome in peptide drug development to realize their potential and provide an overview of recent trends in peptide drug development. In addition, we take an in‐depth look at early efforts in human hormone discovery, smart medicinal chemistry and design, natural peptide drugs, and breakthrough advances in molecular biology and peptide chemistry.
Synthesis of 1‐Aminoisoquinolines and Their Application in a Host‐Guest Doped Strategy To Construct Ultralong Room‐Temperature Phosphorescence Materials for Bioimaging
Authors: Chen Lepeng , Xiong Wenzhang , Ma Yaogeng , Ge Jing‐Yuan , Lv Ningning , Wu Xuan , Chen Jiuxi , Chen Zhongyan 
Published: November 2022

AbstractOrganic ultralong room‐temperature phosphorescence (RTP) materials have attracted great attention for their wide applications in optoelectronic devices and bioimaging. However, the development of these materials remains a challenging task, partially due to the lack of rational molecular design strategies and unclear luminescence mechanisms. Herein, we present a method for facile access to structurally diverse substituted 1‐aminoisoquinoline derivatives through a copper‐catalyzed one‐pot three‐component coupling reaction that provides a promising approach to rapidly assemble a library of 1‐aminoisoquinolines for exploring the regularity of the host‐guest doped system. A series of host‐guest RTP materials with wide‐ranging lifetimes from 4.4 to 299.3 ms were constructed by doping various substituted isoquinolines derivatives into benzophenone (BP). Furthermore, 4 r/BP nanoparticles could be used for in‐vivo imaging with a signal‐to‐noise ratio value as high as 32, revealing the potential of the isoquinoline framework for the construction of high‐performance RTP materials.
Construction and validation of an aging‐related gene signature for prognosis prediction of patients with breast cancer
Authors: Li Jian , Qi Chunling , Li Qing , Liu Fei 
Published: November 2022

AbstractBackgroundBreast cancer (BC) is an aging‐related disease. Aging‐related genes (ARGs) participate in the initiation and development of lung and colon cancer, but the prognosis signature of ARGs in BC has not been clearly studied.AimsThis study aimed to construct an ARGs signature to predict the prognosis of patients with breast cancer.MethodFirstly, the expression data of ARGs from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were collected. Then COX and least absolulute shrinkage and selection operator(LASSO) were performed to construct the ARGs prognostic signature. The correlation between the signature and immune cell infiltration, immunotherapeutic response and drug sensitivity were subsequently analysed. The TCGA nomogram was constructed by combining the signature with other clinical features, and was validated by using GEO database.ResultsAfter LASSO and COX regression analyses, a prognostic signature based on nine ARGs, namely, HSP90AA1, NFKB2, PLAU, PTK2, RECQL4, CLU, JAK2, MAP3K5, and S100B, was built by using the TCGA dataset. Moreover, this risk signature is closely related to immune cell infiltration, immunotherapeutic response, and responses to chemotherapy and targeted therapy. Subsequently, The calibration curve demonstrates that the nomogram agrees well with practical prediction results. The receiver operating characteristic curve and decision‐making curve analysis demonstrate that ARG signature has the better prognosis diagnosis ability and clinical net benefits.ConclusionsTherefore, the proposed ARG prognosis signature is a new prognosis molecular marker of patients with BC, and it can provide good references to individual clinical therapy.
Induction of Type I Diabetes Mellitus in Beagle Dogs Using Alloxan and Streptozotocin
Authors: Araujo Joseph , Paradis Andrea , Mendes Jessica , Petrik Shawn , de Rivera Christina 
Published: November 2022

AbstractThis article describes a protocol for chemically inducing type I diabetes mellitus in beagle dogs using a mixture of alloxan (ALX) and streptozotocin (STZ). ALX and STZ are both cytotoxic, diabetogenic agents that cause necrosis of pancreatic β‐cells and therefore halt the production of insulin. Although both compounds are widely used in experimental animal models of diabetes, standard protocols employing a single high dose of either agent are also implicated in adjacent organ damage. In contrast, combined administration of ALX and STZ allows for the use of lower doses, a method that effectively destroys β‐cells and circumvents unwanted adverse effects. The procedures described in this protocol produce persistent, insulin‐dependent hyperglycemia in beagle dogs using combined doses of ALX and STZ lower than those previously described for a single intravenous administration. This model can be used to test experimental compounds indicated for the treatment of diabetes. © 2022 Wiley Periodicals LLC.Basic Protocol: Induction of type I diabetes mellitus in beagle dogs using alloxan and streptozotocin
Juvenile psammomatoid ossifying fibroma of the maxilla and mandible: A systematic review of published case reports
Authors: R. Chandini , R. Saranya , Mohideen Khadijah , Balasubramaniam Murali , Ghosh Snehashish , Dhungel Safal 
Published: November 2022

AbstractObjectiveThe aim of this study is to evaluate recent evidence‐based data that summarize the clinicopathological findings and treatment along with follow‐up measures taken in terms of published cases of Juvenile psammomatoid ossifying fibroma (JPOF) of the maxilla and mandible by a systematic review.Materials and MethodsThe databases searched were PubMed, MEDLINE, Scopus, Google scholar, and Cross references. Only those case reports of JPOFs published in the English language from 2000 to 2022 were considered. All cases included confirmed JPOF lesions histopathologically. The SR‐included details like clinical and radiographic data, follow‐up details such as recurrence, and the presence of any adverse outcome.ResultsThe database search produced 595 articles from 2000 to 2022, among which 22 case reports were included in the systematic review. The mean age of JPOF occurrence in patients was 18 ± 16 years. A male predilection was noted among patients younger than 14 years of age, whereas a female predilection was noted in patients older than 14 years of age. Frequent involvement of the mandible (56%) compared to the maxilla (44%) was reported. The posterior mandible was the most commonly affected site involving numerous adjacent structures. The expansile nature of the JPOF displayed 57% buccolingual expansion, 50% downward displacement or erosion of the lower border of the mandible and 81% of involvement of the maxillary antrum/pterygoid plate/orbital floor. Among the 20 cases reported, the treatment provided included surgical excision in 45% of the patients, jaw resection in 35% of the patients, and enucleation and curettage in 18% of the patients. Follow‐up details were provided in 80% of the reports that showed recurrence.ConclusionsThe diagnosis of JPOF requires correlation of the clinical and radiographic features with key histopathological features. Although long‐term follow‐up of the case reports has been reported, the data lack information about the long‐term outcomes of JPOF.
Design and implementation of pixel‐based adjustable ESD protection circuits for capacitive fingerprint biometric sensors
Authors: Lin Wei‐Cheng , Hsieh Chun‐Ting , Chang Ming‐Chiu 
Published: November 2022

AbstractThe trade‐off design between ESD endurability and polymer thickness on sensor plate for capacitive fingerprint is emerging in these years since the image quality of fingerprint is vital for biometrics authentication. In this paper, we propose a pixel‐based ESD protection circuitry in parallel to GDPMOS and GGNMOS and an adjustable body terminal in proposed pixel‐based ESD circuit to meet and exceed air discharge ±15 kV without thicker polymer. With the proposed pixel‐based adjustable ESD protection circuit, the maximum air discharge achieved by (18 kV, −17 kV), and 10 out of 10 samples passed +15 kV, and 10 out of 10 samples passed −15 kV. Compared to conventional ground wall fingerprint sensor, the maximum air discharge was stopped by (15 kV, −15 kV), and just merely five out 10 samples passed 15 kV, seven out of 10 samples passed −15 kV. Besides the excellent ESD endurability, the proposed pixel‐based ESD protection circuit achieves air‐discharge 15.5 kV and grayscale count 230 at merely 50 μm thickness of polymer. Compared to the conventionally used ground wall sensor types, it passes only 13 kV and a grayscale count of 210 at a polymer thickness of 50 μm, but fails 15 KV Level 4 of IEC‐61000‐4‐2. Even with polymer thickness increased to 250 μm, ground wall sensor types barely passed 15 kV, and the grayscale count dropped to 120, which is far from PIV image standard.
Child emotion inhibition mediates the effect of parent's adaptive cognitive emotion regulation on child frontal EEG asymmetry during reappraisal
Authors: Meza‐Cervera Tatiana , Tucker Alexandra , Liu Ran , Bell Martha Ann 
Published: November 2022

AbstractCognitive reappraisal is considered an adaptive emotion regulation strategy, but little is known regarding children's ability to effectively implement cognitive reappraisal. Some research indicates that parenting contributes to child cognitive reappraisal ability, with parent's own adaptive cognitive emotion regulation strategies playing a role. Minimal research attempts to examine how child and parenting factors work together to affect child cognitive reappraisal. We examined this association through mediation analyses to determine whether child emotion coping and emotion inhibition would mediate the relation between parent's adaptive cognitive emotion regulation and children's cognitive reappraisal implementation. Children were instructed to implement cognitive reappraisal during a sad film, while electroencephalogram (EEG) was collected. Left frontal EEG asymmetry was conceptualized as effective cognitive reappraisal implementation. Our model supported full mediation for child emotion inhibition. Parent's adaptive cognitive emotion regulation was positively associated with children's emotion inhibition, which was then positively linked to children's left frontal EEG asymmetry during cognitive reappraisal. The model with child emotion coping as a mediator was not supported. Our findings highlight the importance of examining multiple pathways that may impact children's adaptive cognitive reappraisal ability.
Identifying priority reserves favors the sustainable development of wild ungulates and the construction of Sanjiangyuan National Park
Authors: Jiang Feng , Zhang Jingjie , Song Pengfei , Qin Wen , Wang Haijing , Cai Zhenyuan , Gao Hongmei , Liu Daoxin , Li Bin , Zhang Tongzuo 
Published: November 2022

AbstractSanjiangyuan National Park (SNP), the first national park in China, is one of the most important biodiversity conservation areas in the Sanjiangyuan National Nature Reserve (SNNR) and even the world. The threatened ungulates play an irreplaceable role in maintaining the ecosystem diversity and stability in SNNR. Here, based on 1434 occurrence records of six ungulates, the maximum entropy model, with two different strategies, was utilized to determine the priority reserves. The results indicated that the priority reserves in SNNR was mainly located in and around SNP, which were mainly distributed in the middle east, middle west, and southwest of SNNR. Six ungulates shared preference for altitude ranging 4000–5000 m, the average annual temperature below −3.0°C, and average annual precipitation ranging 200–400 mm on meadow, steppe, and unused land. The proportion of high and medium suitable areas for ungulates in SNP was higher than that in SNNR. As the SNP is not contiguously spaced in space, and some core wildlife habitats are not included, it is suggested to optimize the functional areas and adjust the boundary range on the basis of the pilot scope of SNP, so as to enhance the integrity and connectivity of each functional area.
Direct Boronic Acid Promoted Amidation of Carboxylic Acids with Poorly Nucleophilic Amines
Authors: Zhou Jingning , Paladino Marco , Hall Dennis G. 
Published: November 2022

AbstractDirect amidation of carboxylic acids with poorly nucleophilic amines such as anilines is a notorious challenge in organic chemistry. Previously reported methodologies for direct amidation tend to report none or just a few examples with simple anilines, which generally react at temperatures over 100 °C. To address this challenge and develop a mild and direct dehydrative anilide synthesis, herein a series of novel boronic acids with a biphenyl scaffold were prepared based on a design concept of bifunctional activation. The optimal thioether‐substituted biphenylboronic acid, 1e, exhibits good reactivity in promoting the amidation reaction of various anilines at 85 °C in fluorobenzene, including halogenated anilines, electron‐rich and electron‐deficient anilines, and the heterocyclic 6‐aminoquinoline. Variations of the aliphatic carboxylic acid are possible, affording the corresponding anilides in good yields. The efficiency and recyclability of boronic acid 1e were demonstrated on a gram‐scale amidation reaction.
Synthesis and Reactivity of Bidentate N‐Heterocyclic Carbene‐Phosphinidene Supported Si(IV) Dicationic Complexes
Authors: Baierl Ramona , Kostenko Arseni , Hanusch Franziska , Beck Alexander D. , Inoue Shigeyoshi 
Published: November 2022

AbstractHerein, we report the synthesis and isolation of Si(IV) dications stabilized by a bidentate N‐heterocyclic carbene‐phosphinidene (NHCP). Treatment of the bis(NHCP) with Si(IV) bis(triflate) R2Si(OTf)2 (with R=H, Ph) resulted in the instant formation of Si(IV) dicationic complexes [2 a] and [2 b] featuring a tetracoordinated silicon centre. The dications show expected high Lewis acidity. The bis(NHCP)‐stabilized parent silyl dication 2a (SiH22+) presents the first isolable example of a parent SiH2 dication. In addition, dication [2 a] is able to react with diphenylketene by insertion into the Si−P bond.
Political distrust, perceived threat, and intentions to engage in normative and violent collective action: A mixed‐methods study
Authors: Gulliver Robyn , Chan Christian S. , Tam Katy Y. Y. , Lau Iris S. K. , Hong Ying Yi , Louis Winnifred R. 
Published: November 2022

AbstractIn three studies, we examined the role of distrust and perceived threat in intentions to engage in normative and violent non‐normative collective action. A field‐based qualitative study of 35 pro‐democracy protestors during the 2019 Hong Kong Anti‐Extradition protests revealed that perceived threat to Hong Kong values alongside distrust of political institutions spurred collective action engagement and support for defensive violent collection action. In Study 2, a questionnaire (N = 639) testing pro‐democracy action intentions demonstrated direct paths on both normative and violent collective action intentions from distrust and threat. In Study 3 (N = 133), experimental trust and threat manipulations demonstrated a significant association between distrust and threat on violent collective action intentions and acceptance, and a significant interaction on acceptance of violent collective action. Our results reveal the importance of distrust and threat in attitudinal support for, and engagement in, collective action and their role in transitioning from non‐violent to violent collective action.
Zangalou Manto‐type deposit in the Sabzevar zone, northeast Iran: Evidence of mineralogy, geochemistry,U–Pbdating, fluid inclusion, and stable isotopes
Authors: Ghelichkhani Mehdi , Malekzadeh Shafaroudi Azadeh , Karimpour Mohammad Hassan , Homam Seyed Masoud 
Published: November 2022

The Zangalou Cu deposit lies in the Sabzevar volcanic‐plutonic zone, northeastern Iran. The deposit is hosted by the middle Eocene volcanic‐sedimentary sequences and it has been affected by propylitic, carbonate, sericitic, and minor argillic alterations. The volcanics have features typical of calc‐alkaline and metaluminous magmas and are plotted in the continental volcanic arc region. Zircon U–Pb dating of the andesite porphyry yield ages of 41.2 and 38.4 Ma (Bartonian). Ore mineralization occurs as stratabound with open‐space filling, dissemination, veinlet, and replacement textures in mineralized conglomerate, andesite porphyry, and trachyandesite host rocks. Cu content in Zangalou deposit vary from 1,234 g/t to 6.24% which mostly occurred as chalcocite mineral. Fluid inclusion data of mineralization‐related calcites indicate medium salinities (12.8–16.6 wt.% NaCl equivalents) and a wide range of temperatures (154–295°C) and show evidence of fluid cooling trend during the ore formation. The δ13C (between 19.3 and −2.8‰) and δ18OSMOW(between 24.8 and 25.34‰) values of ore‐related calcites suggests a contribution of sedimentary organic matter and marine carbonates as the source of carbon in the ore‐forming fluid. High positive δ34S values (27.8–33.47‰) suggest that the source of sulphur is related to sedimentary country rocks. Mineralization is lithologically and structurally controlled and it is epigenetic. According to geological, petrological, alteration, mineralization textures and geometry of deposit, fluid inclusion, and isotopic studies, the Zangalou deposit is similar to manto‐type deposits.
Digitalization of cross‐border R&D alliances: Configurational insights and cognitive digitalization biases
Authors: Bouncken Ricarda B. , Fredrich Viktor , Sinkovics Noemi , Sinkovics Rudolf R. 
Published: November 2022

AbstractResearch SummaryFirms implement digital technology for improving coordination and communication in cross‐border R&D alliances. However, there is great ambivalence regarding how digitalization influences cross‐border knowledge transfers. Our analysis clarifies some of this ambivalence by providing different configurations of absorptive capacity in cross‐border R&D alliances. The fuzzy‐set qualitative comparative analysis (fsQCA) reveals only low absorptive capacity achievement in most configurations of digital technology implementation. The findings indicate effects of cognitive digitalization biases, under which firms take the benefits of digital technology for granted while ignoring deep‐level challenges rooted in the contextuality of international ties. However, high absorptive capacity is achievable when (1) allying with bigger and younger partners, (2) under technological similarity, and (3) coping with the associated digitalization biases.Managerial SummaryFirms are eager to grasp the potential of digital technology. Within R&D alliances, digital technology is deemed to facilitate better coordination and communication. However, advantages from digital transformation are not always realized, as firms may overestimate the ease and usability of the underpinning technologies. We find that learning and understanding of partner knowledge is improved when R&D partnerships are forged between bigger and smaller partners, when partners feature technological similarities and both parties are similarly minded regarding technologies and do not take technology advantages for granted.