bluuebunny/crossref_metadata_2025_split huggingface dataset:
University Social Mission in the Wartime under Knowledge Society
Authors: Orzhel Olena 
Published: August 2022

The article is dedicated to the growing social role of universities under knowledge society and its revision during wartime and post-war revival. This role has not received due attention of Ukrainian scholars and higher education stakeholders; on the contrary, in western academic discourse university third mission (also referred to as social mission) is actively discussed and several studies on university roles during conflict and post-conflict recovery are available. The article aims at conceptualization of university third mission relevant for Ukraine’s higher education of today as the country is striving towards knowledge society, higher education modernization and its alignment with European Higher Education Area, as well as fighting against Russian Federation aggression and planning economic recovery and national revival. Knowledge is a key concept in interpretation and definitions of three university missions: knowledge is generated or produced via research (second mission); it is disseminated and promoted via teaching and learning (first mission); the essence of the third / social mission is to apply knowledge for problem-solving and general societal benefit. Application of knowledge is not limited to technological innovations and know-hows and covers social, humanitarian, cultural, business and entrepreneurship, economic, political and other domains. Knowledge is becoming the major problem-solving tool; and demand for knowledge is growing among different categories of knowledge workers engaged in problem definition, decision-making and implementation in different economic sectors and spheres of life. Problems and challenges incurred by war make them the most serious grievances of today’s Ukraine. Multiple challenges faced by Ukrainian society, economy, territories, industries will require the wisdom of all Ukrainian higher education institutions and knowledge workers and can only be addressed effectively via innovative approaches and mobilization of many partners: local and international, academic and non-academic, private and public, non-profit and commercial. Due to their specific features (multidiscipline expertise, access to international knowledge sharing and good practices exchange, non-profit focus, multiple perspectives and diversity of opinions), universities like no other institutions are well-positioned to establish and run partnerships, project consortia, lead innovation ecosystems, catalyse and contribute to reconstruction and revival processes.
Financial Policies of Higher Educational Institutions
Authors: Shofolova Nataliia 
Published: August 2022

In the context of legal regulation and restrictions on public funding of higher educational institutions and competition in the search for additional resources, the efficiency of the use of funds, openness and accountability of the expenditures are extremely important. The implementation of university financial policies will help to support a system of financial management, increase the level of financial autonomy, promote publicity and transparency in financial decision-making and facilitate management decisions towards achieving strategic goals.
The article considers the theoretical foundations of financial policies in higher education institutions. University financial policies is defined as a purposeful activity of the management team aimed at making effective financial decisions to achieve and maintain financial sustainability and stable development of the university, achieving its strategic goals and current tasks, based on developing alternative algorithms with clear distribution of the powers and responsibilities.
Arguments for the necessity to implement university financial policies as a mechanism to expand the financial autonomy, increase the competitiveness of the institution, reduce financial risks, ensure integrity and social responsibility, increase the efficiency of financial management, simplify of financial processes, and improve the quality of educational services are substantiated.
The recommendations of projects and guides on financial policies and procedures and the experience of British universities on the content of financial policies are analyzed, as well as the main components of financial policies for Ukrainian universities are proposed.
Processing induced changes on coarse cereals (majorly millets) derived antioxidant compounds - a review
Authors: Aggarwal Dipesh , Bhardwaj Aastha , Sobti Anupreet Kaur , Fatma Sana , Sharma Nitya , Bansal Vasudha 
Published: August 2022

Coarse cereals also known as nutricereals contain several bioactive components that provide many health-promoting and disease-preventing properties. This paper presents a review of the effect of processing on the various antioxidant compounds present in coarse cereals. Polyphenols, phenolic compounds, flavonoids, tannins, avenanthramides, vitamins, and phytoestrogens are the major categories that contribute to the antioxidant properties of coarse cereals. As per the literature, processing technologies like fermentation, boiling, malting, hydrolysis, soaking and germination, heat treatment, microwaving and extrusion, etc, have a significant effect on these antioxidant compounds present in coarse cereals. Coarse cereals and their processed products could be of potential benefit to human health, but extensive research is required to optimize the dietary recommendation for realizing these health benefits.Keywords: Millets; flavonoids; polyphenols, processing techniques
TO THE QUESTION OF UNITED NATIONS COUNTER-TERRORISM ACTIVITIES
Authors: Бородаенко Анна Андреевна 
Published: August 2022

Abstract. The article is devoted to the study of a number of aspects of United Nations counter-terrorism activities in the current phase of globalization. Purpose: to analyze the problems directly related to the activities of the UN in the field of countering international terrorism, as well as the basic provisions of the UN Global Counter-Terrorism Strategy (2006). Methods: the study uses comparison, description, analogy, dialectical logic, interpretation of legal norms, content-analysis, synergistic method. Results: the study substantiates the main conclusion that UN counter-terrorism activities are a major factor in the maintenance of international peace and security, representing a synergy of efforts among UN bodies and system, aimed at countering and combating terrorism. The article identifies the problems that are hampering the progressive development and improvement of United Nations counter-terrorist activities at the present time. It is noted in particular that none of the universal international legal instruments against terrorism currently contains a clear definition of the concept of «international terrorism». This circumstance hinders the development and potential adoption of the UN Comprehensive Convention against International Terrorism, proposed at the time by the delegation of India. The author believes that this long-standing problem, which has been trying to be resolved for a quarter of a century in negotiations within the UN, is unlikely to be solved by the current generation of politicians and leaders: there are too many disagreements that lead to deadlock in the relevant negotiations. It is suggested that the institutional reform of the UN counter-terrorism architecture, aimed at strengthening the common approach to coordination and coherence in the UN system of counter-terrorism activities, launched by the new Secretary-General António Guterres in 2018, will be fruitfully continued in the near future.
Modification of bladder thermodynamics in stress urinary incontinence patients submitted to trans-obturator tape: A retrospective study based on urodynamic assessment
Authors: Lau Hui-Hsuan , Lai Cheng-Yuan , Peng Hsien-Yu , Hsieh Ming-Chun , Su Tsung-Hsien , Lee Jie-Jen , Lin Tzer-Bin 
Published: August 2022

Importance: It needs to be clarified whether trans-obturator tape (TOT)-enhanced urethral resistance could impact the voiding function.Objective: Although TOT has been well-recognized for enhancing urethral resistance to restore continence in stress urinary incontinence (SUI) patients, whether the bladder’s voiding functions adapt to the TOT-enhanced resistance has not been adequately investigated. This study thereby aimed to investigate whether TOT impacts the bladder’s thermodynamic efficacy during the voiding phase.Design: A retrospective analysis of urodynamics performed before and after TOT was assessed.Setting: A tertiary referral hospital in Taiwan.Participants: A total of 26 female SUI patients who underwent urodynamic investigations before and after TOT.Main outcomes and measures: The area enclosed by the pressure-volume loop (Apv), which represents the work performed by the bladder during voiding, in a pressure-volume analysis established by plotting the detrusor pressure versus intra-vesical volume was retrospectively analyzed. Paired Student’s t-tests were employed to assess the difference in values before and after the operation. Significance in difference was set at p &lt; 0.05.Results: TOT increased Apv in 20 of 26 (77%) patients and significantly increased the mean Apv compared to the preoperative control (2.17 ± 0.18 and 1.51 ± 0.13 × 103 cmH2O-ml, respectively p &lt; 0.01). TOT also increased the mean urethral resistance (1.03 ± 0.30 vs. 0.29 ± 0.05 cmH2O-sec/ml, p &lt; 0.01) and mean voiding pressure (25.87 ± 1.72 and 19.30 ± 1.98 cmH2O p &lt; 0.01) but did not affect the voided volume and voiding time. Moreover, the TOT-induced Apv increment showed a moderate correlation with the changes in urethral resistance and voiding pressure (both r &gt; 0.5) but no correlation with changes in voided volume or voiding time. It is remarkable that the TOT-induced urethral resistance increment showed a strong correlation with changes in voiding pressure (r &gt; 0.7).Conclusion and Relevance: The bladder enhances thermodynamic efficacy by adapting the voiding mechanism to increased urethral resistance caused by TOT. Further studies with higher case series and longer follow-ups should assess whether this effect could be maintained over time or expire in a functional detrusor decompensation, to define diagnostic criteria that allow therapeutic interventions aimed at its prevention during the follow-up.Clinical Trial Registration: (clinicaltrials.gov), identifier (NCT05255289)
Biomechanical comparative analysis of effects of dynamic and rigid fusion on lumbar motion with different sagittal parameters: An in vitro study
Authors: Wang Wei , Kong Chao , Pan Fumin , Wang Yu , Wu Xueqing , Pei Baoqing , Lu Shibao 
Published: August 2022

Background: Although the management of the lumbar disease is highly dependent on the severity of the patient’s condition, optimal surgical techniques to reduce the risk of adjacent degeneration disease (ADS) remain elusive. Based on in vitro biomechanical tests of the cadaver spine, this study aimed to comparatively analyze the kinematic responses of the spine with dynamic and rigid fixations (i.e., Coflex fixation and posterolateral fusion) after single-or double-level lumbar fusion in daily activities.Methods: Six human lumbar specimens (L1-S1) were selected for this experiment, and the sagittal parameters of each lumbar specimen were measured in the 3D model. The specimens were successively reconstructed into five groups of models: intact model, single-level L4-5 Coflex fixation model, single-level L4-5 Fusion (posterior pedicle screw fixation) model, double-level L4-5 Coflex + L5-S1 Fusion model; and double-level L4-5 Fusion + L5-S1 Fusion model. The pure moment was applied to the specimen model to simulate physiological activities in daily life through a custom-built robot testing device with an optical tracking system.Results: For single-level lumbar fusion, compared to the traditional Fusion fixation, the Coflex dynamic fixation mainly restricted the extension of L4-L5, partially retained the range of motion (ROM) of the L4-L5 segment, and reduced the motion compensation of the upper adjacent segment. For the double-level lumbar fixation, the ROM of adjacent segments in the Coflex + Fusion was significantly decreased compared to the Fusion + Fusion fixation, but there was no significant difference. In addition, PT was the only sagittal parameter of the preoperative lumbar associated with the ROM under extension loading. The Coflex fixation had little effect on the original sagittal alignment of the lumbar spine.Conclusion: The Coflex was an effective lumbar surgical technique with a less altering kinematic motion of the lumbar both at the index segment and adjacent segments. However, when the Coflex was combined with the fusion fixation, this ability to protect adjacent segments remained elusive in slowing the accelerated degradation of adjacent segments.
Pan-cancer analysis of the angiotensin II receptor-associated protein as a prognostic and immunological gene predicting immunotherapy responses in pan-cancer
Authors: Hong Kai , Zhang Yingjue , Yao Lingli , Zhang Jiabo , Sheng Xianneng , Song Lihua , Guo Yu , Guo Yangyang 
Published: August 2022

Background: Understanding interior molecular mechanisms of tumorigenesis and cancer progression contributes to antitumor treatments. The angiotensin II receptor-associated protein (AGTRAP) has been confirmed to be related with metabolic products in metabolic diseases and can drive the progression of hepatocellular carcinoma and colon carcinoma. However, functions of AGTRAP in other kinds of cancers are unclear, and a pan-cancer analysis of AGTRAP has not been carried out.Methods and materials: We downloaded data from The Cancer Genome Atlas and Genotype-Tissue Expression dataset and The Human Protein Atlas databases and then used R software (version 4.1.1) and several bioinformatic tools to conduct the analysis.Results: In our study, we evaluated the expression of AGTRAP in cancers, such as high expression in breast cancer, lung adenocarcinoma, and glioma and low expression in kidney chromophobe. Furthermore, our study revealed that high expression of AGTRAP is significantly related with poor prognosis in glioma, liver cancer, kidney chromophobe, and so on. We also explored the putative functional mechanisms of AGTRAP across pan-cancer, such as endoplasmic reticulum pathway, endocytosis pathway, and JAK-STAT signaling pathway. In addition, the connection between AGTRAP and tumor microenvironment, tumor mutation burden, and immune-related genes was proven.Conclusion: Our study provided comprehensive evidence of the roles of AGTRAP in different kinds of cancers and supported the relationship of AGTRAP and tumorous immunity.
Decreased level of soluble receptor activator of nuclear factor-κβ ligand (sRANKL) in overweight and obese children
Authors: Erazmus Michał , Rumińska Małgorzata , Witkowska-Sędek Ewelina , Kucharska Anna M. , Stelmaszczyk-Emmel Anna , Majcher Anna , Pyrżak Beata 
Published: August 2022

IntroductionChildhood obesity contributes to the development of cardiovascular diseases. The molecular pathway – receptor activator of nuclear factor-κβ ligand (RANKL), its receptor RANK and osteoprotegerin (OPG) - takes part not only in bone metabolism but is also involved in the atherosclerosis process. RANKL stimulates osteogenic differentiation and calcification of vascular smooth cells. The associations between the OPG-sRANKL system and various cardiovascular risk factors were displayed. We aimed to evaluate the relationships between serum sRANKL (soluble RANKL) levels and the OPG/sRANKL ratio with cardiometabolic risk factors in overweight and obese children.Material and methodsThe study included 70 children with overweight and obesity (mean age 13.0 ± 2.8) and 35 age-matched normal weight, healthy peers as a control group. In all patients, anthropometric measurements and laboratory tests were performed. Additionally, an oral glucose tolerance test (OGTT) was made only in overweight and obese children. Atherogenic and insulin resistance indices were calculated.ResultsOverweight and obese children had lower sRANKL levels compared to the control group (median 276.95 vs 325.90, p=0.011), and consequently a higher OPG/sRANKL ratio (0.02 vs 0.01, p = 0.013). The studied children in the lowest quartile of sRANKL levels had higher body weight, Body Mass Index, waist circumference and increased glucose and insulin levels 60 minutes after OGTT and higher uric acid values compared to children in the highest quartile. In multivariable linear regression analysis sRANKL negatively correlated only with uric acid (β = - 0.508, p = 0.041). No association was found for the OPG/sRANKL ratio.ConclusionExcess fat mass seems to alter the OPG/RANKL ratio mainly by reducing serum sRANKL levels. The correlation between sRANKL and uric acid may suggest a contribution of the OPG-sRANKL system in the cardiometabolic process, but that observation should be confirmed in future studies.
Patient reported outcome measures in children and adolescents with type 1 diabetes using advanced hybrid closed loop insulin delivery
Authors: Gianini Ana , Suklan Jana , Skela-Savič Brigita , Klemencic Simona , Battelino Tadej , Dovc Klemen , Bratina Nataša 
Published: August 2022

PurposeTo determine the impact of advanced hybrid closed - loop (AHCL) insulin delivery on quality of life, metabolic control and time in range (TIR) in youth with type 1 diabetes mellitus (T1DM).MethodsTwenty-four children and adolescents with T1DM (14 female) aged of 10 to 18 years participated in the study. Mixed methods study design was implemented. Quantitative part of the study was conducted as a longitudinal crossover study with data collection before and at the end of AHCL use. Qualitative data were obtained with modeled interviews of four focus groups before and the end of the period. Clinical data were collected from the electronic medical records.ResultsThe use of AHCL significantly improved the quality of life in terms of decreased fear of hypoglycemia (p&lt;0.001), decrease in diabetes-related emotional distress (p&lt;0.001), and increased wellbeing (p=0.003). The mean A1C decreased from 8.55 ± 1.34% (69.9 ± 12.3 mmol/mol) to 7.73 ± 0.42 (61.1 ± 2.2 mmol/mol) (p=0.002) at the end of the study. Mean TIR was 68.22% (± 13.89) before and 78.26 (± 6.29) % (p&lt;0.001) at the end of the study.ConclusionThe use of advanced hybrid closed loop significantly improved the quality of life and metabolic control in children and adolescents with T1DM.
Prognostic and immunological role of cuproptosis-related protein FDX1 in pan-cancer
Authors: Xiao Chen , Yang Linhui , Jin Liangzi , Lin Weiguo , Zhang Faqin , Huang Shixin , Huang Zhijian 
Published: August 2022

Background: Cancer is the second cause of death worldwide. Copperoptosis is a new mode of regulated cell death and is strongly associated with metabolic pathways. FDX1 is a key gene that promotes copperoptosis, and its impact on tumor pathogenesis and tumor immune response is indistinct and needs further exploration.Methods: Data was mined from the Cancer Genome Atlas database, the Broad Institute Cancer Cell Line Encyclopedia database, and the International Cancer Genome Consortium. Survival analyses included the Kaplan–Meier method for calculating the cumulative incidence of survival events and the log-rank method for comparing survival curves between groups. Immune cell infiltration levels were calculated using the Spearman correlation test and correlated with FDX1 expression to assess significance. More correlation analyses between FDX1 expression and mutational markers, such as tumor mutational burden (TMB) and microsatellite instability (MSI), were also examined via Spearman assay to explore the relation between FDX1 expression and the sensitivity of common antitumor drugs.Results: FDX1 expression was downregulated in most kinds of cancers, and this high expression indicated better overall survival and death-specific survival. For several cancer types, FDX1 expression had a positive correlation with immune cell infiltration, and FDX1 also had a positive correlation with TMB and MSI in some cancer types, linking its expression to the assessment of possible treatment responses.Conclusion: The correlations between FDX1 expression and cancer in varioustissues, including clear links to cancer survival and prognosis, make FDX1 aninteresting biomarker and potential therapeutic target for cancer surveillance and futureresearch.
Identification of cuproptosis-related subtypes, characterization of tumor microenvironment infiltration, and development of a prognosis model in breast cancer
Authors: Li Zhi , Zhang Hua , Wang Xixi , Wang Qun , Xue Jiapeng , Shi Yun , Wang Minghua , Wang Geng , Zhang Jianquan 
Published: August 2022

Breast cancer (BC) is now the most frequent and lethal cancer among women. Cuproptosis is a newly identified programmed cell death process that has been connected to tumor therapeutic sensitivity, patient outcomes, and the genesis of cancer. Cuproptosis-related genes (CRGs) are involved in breast cancer, although their roles and potential mechanisms are still unclear. First, we examined the effect of gene mutations and copy number changes on overall survival in 1168 breast cancer samples. Breast cancer patients were split into two molecular categories as determined by the variation in CRG based on clinicopathological traits, overall survival, and cell-infiltrating traits in tumor microenvironments. In addition, we created and validated a CRG score to calculate breast cancer patients' OS. Finally, we created a comprehensive nomogram for the clinical use of the CRG score. Patients whose CRG scores were low showed increased odds of developing OS, a larger mutation load, and immunological activation than those with high CRG scores. The CRG score, the cancer stem cell index, and the responsiveness to chemotherapy or targeted therapies were also shown to be statistically significantly correlated. Our thorough examination of CRGs in breast cancer patients demonstrated that they may be useful predictors of prognosis, clinical characteristics, and tumor microenvironment. These findings provide fresh insight into CRGs in breast cancer and might inspire brand-new approaches to both diagnosing and treating patients there.
Effects of graphene content on the microstructure and mechanical properties of alumina-based composites
Authors: Zhu Jun , Jia Bi , Di Yongjiang , Liu Biao , Wan Xin , Wang Wenrong , Tang Rui , Liao Shu , Chen Xingyu 
Published: August 2022

In this work, alumina-graphene (Al2O3-G) composites with graphene contents ranging from 0.5 to 3% were prepared by stepwise feeding ball milling and hot pressing. The influences of graphene content on the microstructure and mechanical properties of Al2O3-G composites were investigated. Results showed that the densification, grain sizes, flexural strength, fracture toughness and Vickers hardness of materials increased firstly and then decreased with increasing graphene contents. When the graphene content was 1%, the value of each performance parameter reached the maximum. The average grain size of material decreased from 991 to 551 nm as the graphene content increased from 0 to 1%, but it increased to 863 nm when the graphene content was 3%. The flexural strength, fracture toughness and Vickers hardness of composites with graphene content of 1% increased to 763.5 MPa, 7.4 MPa m1/2 and 21.28 GPa. Compared with the Al2O3, the fracture strength and toughness of the composites increased by up to 54.63 and 65.54%. Analysis suggested that the strength of Al2O3-G composites was mainly related to the grain size and preexisting microflaws.