bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turning the flywheel: mobilizing the JBI model of evidence-based healthcare
Authors: Jordan Zoe , Pilla Bianca , Porritt Kylie , Munn Zachary , Aromataris Ed , Lockwood Craig 
Published: September 2022

ABSTRACT
Since its emergence in the 1990s, evidence-based healthcare (EBHC) has made great strides in locating, synthesizing, summarizing, and disseminating evidence, but sustainable mechanisms for getting trustworthy evidence into policy and practice continues to be less well understood. We propose that there is an EBHC ‘Flywheel’ that begins and ends with culture and the development of adaptive but disciplined approaches that generate new ‘norms’ in relation to EBHC. In mechanics, a flywheel is a device that uses momentum to create rotational energy. The concept of a ‘flywheel effect’ has been adopted in management fields to demonstrate how change in organizations or practices rarely happen in one fell swoop; rather, sustainable change requires energy and persistent effort.
This energy might be exemplified by leadership to get the wheel moving, but it needs to be guided, channelled, harnessed and supported throughout the rest of the organization. To achieve sustainable momentum, it is necessary to communicate with transparency the EBHC principles, practices, and perspectives that are considered of broad organizational value to generate cohesion and understanding about practice expectations. With a common vision, cooperation and collective identity in place, true multidisciplinary collaboration underpinned by EBHC is possible. The final component in the EBHC flywheel, capacity, is self-generating (i.e. you do not need ‘more time’ or ‘more resource’ for EBHC as EBHC is embedded in the fabric and fibre of the organization). This shifts the notion of EBHC initiatives from being ‘in addition to’ or being singular one-off initiatives or projects to being part of the lifeblood of how the organization functions. EBHC is, ultimately, a human-to-human endeavour. It relates to individuals connecting and committing to a common purpose. The ‘four C's’ that underpin the JBI Model (culture, communication, collaboration, and capacity) are the organizational navigational instruments and roadmaps required to provide the human focus/lens that is needed.
The role of perceived expertise and trustworthiness in research study and clinical trial recruitment: Perspectives of clinical research coordinators and African American and Black Caribbean patients
Authors: Morgan Susan E. , Harrison Tyler R. , Wright Kallia O. , Jia Xiaofeng , Deal Bonnie , Malova Kate 
Published: September 2022

AbstractThis study investigates the role of source credibility on minority participant recruitment, particularly African American and Black Caribbean patients. A total of nine focus groups (N = 48 participants) were conducted with both patient groups and clinical research coordinators (CRCs). Using the elaboration likelihood model as a guiding framework for analysis, this study found that the credibility of research coordinators (or other professionals who recruit for research studies and clinical trials) was instrumental in shaping attitudes of prospective participants. The perspectives of patients and CRCs aligned closely, with few exceptions. For both groups, professionalism and professional displays (clothing, institutional artifacts) enhanced perceived expertise, a core component of credibility. Trustworthiness, another important component of credibility, was fostered through homophily between recruiter and patient, expressions of goodwill and assuaging anxiety about CRCs’ financial motivations for recruitment. Additionally, CRCs believed that credibility was supported when CRCs could emphasize transparency and truthfulness in communication. The importance of these findings for the development of empirically-based training programs to improve communication practices in recruitment contexts is discussed.
Age-associated sleep-wake patterns are altered with Prdm13 signaling in the dorsomedial hypothalamus and dietary restriction in mice
Authors: Tsuji Shogo , Brace Cynthia S , Yao Ruiqing , Tanie Yoshitaka , Tada Hirobumi , Rensing Nicholas , Mizuno Seiya , Almunia Julio , Kong Yingyi , Nakamura Kazuhiro , Ogiso Noboru , Toyokuni Shinya , Takahashi Satoru , Wong Michael , Imai Shin-ichiro , Satoh Akiko 
Published: September 2022

AbstractOld animals display significant alterations in sleep-wake patterns such as increases in sleep fragmentation and sleep propensity. Here we demonstrated that dorsomedial hypothalamus-specific PR-domain containing protein 13-knockout (DMH-Prdm13-KO) mice recapitulated age-associated sleep alterations such as sleep fragmentation and increased sleep attempts during sleep deprivation (SD). These phenotypes were further exacerbated during aging, with increased adiposity and decreased physical activity, resulting in shortened lifespan. Dietary restriction (DR), a well-known anti-aging intervention in diverse organisms, ameliorated age-associated sleep alterations, whereas these effects of DR were abrogated in DMH-Prdm13-KO mice. Moreover, overexpression of Prdm13 in the DMH ameliorated sleep fragmentation and excessive sleepiness during SD in old mice. Therefore, maintaining Prdm13 signaling in the DMH might play an important role to control sleep-wake patterns during aging.
Interneuron-targeted disruption of SYNGAP1 alters sensory representations in neocortex and impairs sensory learning
Authors: Zhao Meiling , Kwon Sung Eun 
Published: September 2022

AbstractSYNGAP1 haploinsufficiency in humans results in severe neurodevelopmental disorders characterized by intellectual disability, autism, epilepsy, and sensory processing deficits. However, circuit mechanisms that underlie SYNGAP1-related neurodevelopmental disorders are poorly understood. A decrease of SynGAP in mice causes cognitive and behavioral deficits in part by disrupting the development of excitatory glutamatergic connections. Whether and to what extent SynGAP functions in inhibitory circuits remain unclear. We show that interneuron-specific SYNGAP1 heterozygous mice display learning deficits characterized by elevated behavioral responses in the absence of relevant sensory input and premature responses to a sensory input unrelated to reward acquisition. These behavioral deficits are associated with specific circuit abnormalities within primary somatosensory cortex, characterized by increased detrimental correlations and elevated responses to irrelevant sensory stimuli. Collectively, we show that a decrease of SynGAP in inhibitory interneurons disrupts sensory representation in the primary sensory cortex, which likely contributes to behavioral deficits.
The Neurotoxin DSP-4 Dysregulates the Locus Coeruleus-Norepinephrine System and Recapitulates Molecular and Behavioral Aspects of Prodromal Neurodegenerative Disease
Authors: Iannitelli Alexa F. , Kelberman Michael A. , Lustberg Daniel J. , Korukonda Anu , McCann Katharine E. , Mulvey Bernard , Segal Arielle , Liles L. Cameron , Sloan Steven A. , Dougherty Joseph D. , Weinshenker David 
Published: September 2022

AbstractThe noradrenergic locus coeruleus (LC) is among the earliest sites of tau and alpha-synuclein pathology in Alzheimer’s disease (AD) and Parkinson’s disease (PD), respectively. The onset of these pathologies coincides with loss of noradrenergic fibers in LC target regions and the emergence of prodromal symptoms including sleep disturbances and anxiety. Paradoxically, these prodromal symptoms are indicative of a noradrenergic hyperactivity phenotype, rather than the predicted loss of norepinephrine (NE) transmission following LC damage, suggesting the engagement of complex compensatory mechanisms. Because current therapeutic efforts are targeting early disease, interest in the LC has grown, and it is critical to identify the links between pathology and dysfunction. We employed the LC-specific neurotoxin DSP-4, which preferentially damages LC axons, to model early changes in the LC-NE system pertinent to AD and PD in male and female mice. DSP-4 (2 doses of 50 mg/kg, 1 week apart) induced LC axon degeneration, triggered neuroinflammation and oxidative stress, and reduced tissue NE levels. There was no LC cell death or changes to LC firing, but transcriptomics revealed reduced expression of genes that define noradrenergic identity and other changes relevant to neurodegenerative disease. Despite the dramatic loss of LC fibers, NE turnover and signaling were elevated in terminal regions and were associated with anxiogenic phenotypes in multiple behavioral tests. These results represent a comprehensive analysis of how the LC-NE system responds to axon/terminal damage reminiscent of early AD and PD at the molecular, cellular, systems, and behavioral levels, and provides potential mechanisms underlying prodromal neuropsychiatric symptoms.
An AMOS-SEM approach to evaluating stakeholders' influence on construction project delivery performance
Authors: AL-Fadhali Najib 
Published: September 2022

PurposeConstruction project stakeholders can have a major effect on delivering projects on time. However, little attempt has been made to address the influence of internal stakeholders on delaying project delivery. This research aims to propose the internal stakeholders' influence as a solution to improving project delivery performance (PDP) in order to boost the value of investment in the construction industry's projects.Design/methodology/approachIn Yemen, a structured questionnaire was distributed to owners, consultants and contractors, 283 of which were found usable after the data screening. A purposeful sampling technique was used and structural equation modelling (SEM) was adopted for analysis. The structural model was drawn up, based on seven categories of influencing factors: labour, supplier, designer, contractor, consultant, sub-contractor and owner.FindingsThe results of the structural model suggest that of these seven categories, designers, owners, suppliers and subcontractors have a significant p-value and impact on PDP, while the labour and consultant's impact was not substantiated. The findings support the proposal that internal stakeholders' influence contributes directly to construction PDP.Originality/valueThe influence of stakeholders on PDP is important. Nonetheless, few studies have focussed on their effectiveness, especially in developing countries. This paper's contribution is evaluating the cause–effect relationship between stakeholders' influence and construction PDP through analysis of moment structures (AMOS) analysis. The policy implications of the research are to encourage governments in general and construction companies in particular to take responsibility for improving PDP, as slow execution of construction projects leads to increased costs, failure and abandoning projects.
The role of HEIs to achieve SDG7 goals from Netzero campuses: case studies and possibilities in Brazil
Authors: Matana Júnior Sidnei , Antonio Leite Frandoloso Marcos , Barbosa Brião Vandré 
Published: September 2022

Purpose
Energy consumption and renewable energy sources are included in the goals for the 2030 Sustainable Development Goal 7 (SDG7) agenda, and target buildings are the biggest electricity consumers. In turn, Netzero energy buildings (NZEB) contribute to achieve SDG7 goals. This paper aims to identify which Brazilian higher education institutions (HEIs) practices contribute to developing the NZEB concept.

Design/methodology/approach
Case studies were selected to identify which implanted practices applied by HEIs in Brazil, listed in the UI GreenMetric 2020 Ranking, are related to the NZEB concept. The implemented sustainable practices were also analyzed to evaluate the connections and impact between universities and the local community.

Findings
Results show the lighting and air conditioning retrofit were among the most common practices related to energy efficiency to reduce consumption. For renewable energy generation, photovoltaic solar energy is the most common practice used by HEIs.

Research limitations/implications
Only Brazilian HEIs listed in the UI Green Metric Ranking were analyzed. No standard regulation or formal reports support the wide dissemination of the strategies adopted by HEIs in Brazil.

Practical implications
The strategies adopted by HEIs related to Netzero buildings can reduce emissions, optimize operating costs and improve building comfort conditions, which connect all SDGs.

Social implications
HEIs can promote awareness related to energy use and clean energy generation within the local community.

Originality/value
This paper presents the most common strategies adopted by Brazilian HEIs. However, limitations related to lack of strategies, data transparency and specific Netzero energy regulation were also found. These issues can hinder other HEIs to adopt similar strategies and contribute to the promotion of SDG7 in Brazil.
Investigating the effects of innovation intensity and lenders’ monitoring on the relation between financial slack and performance
Authors: Jermias Johnny , Yigit Fatih 
Published: September 2022

Purpose
The purpose of this study is to investigate the moderating roles of innovation intensity and lenders’ monitoring on the relation between financial slack and performance.

Design/methodology/approach
This study adopts an empirical method using data from firms listed in both the Compustat S&P500 and Boardex for the period 2010 to 2019 to analyze the effects of innovation intensity and lenders’ monitoring on the relation between financial slack and performance.

Findings
The authors find that financial slack is positively related to performance, and this relation is stronger as innovation intensity increases. Furthermore, we demonstrate that lenders’ monitoring strengthens the positive relationship between financial slack and performance.

Research limitations/implications
First, this study focuses on the effects of financial slack, research and development (R&D) intensity and lenders’ monitoring on financial performance. Future research might extend this study by investigating the effects of these variables on non-financial performance. Second, the data and results do not provide insights into the reasons for firms to accumulate financial slack. Future research might conduct a longitudinal field study to understand why firms build financial slack. Finally, this study only uses R&D intensity and lenders’ monitoring as the moderating variables. Future studies might incorporate other contingency variables such as firms’ budgeting and budget-based compensation systems to provide useful insights into the relationship between financial slack and performance.

Practical implications
This study provides important insights into the value of financial slack for firms that invest heavily in R&D activities. This study also provides useful insight into the benefits of lenders’ monitoring to mitigate managers’ unethical behavior.

Social implications
This study provides useful insights for companies that invest heavily in innovation activities by showing that financial slack is beneficial for this company and lenders’ monitoring is needed to discipline managers in using the slack resources.

Originality/value
This study is the first to investigate the moderating effects of innovation intensity and lenders’ monitoring on the relation between financial slack and performance. Previous studies focus their investigations on the direct effect of financial slack and performance.
Role of corporate social responsibility authenticity in developing perceived brand loyalty: a consumer perceptions paradigm
Authors: Safeer Asif Ali , Liu Hancheng 
Published: September 2022

Purpose
Authenticity has become increasingly dominant in business practices, particularly in branding and corporate social responsibility (CSR) activities, as consumers want it in all aspects of their lives. Thus, the purpose of this study is to examine the role of perceived CSR authenticity in predicting perceived brand loyalty (i.e. brand trust, positive word of mouth [PWOM]) via perceived brand authenticity by considering the moderating effects of brand image on perceived brand authenticity and loyalty to determine its influence in the global branding context.

Design/methodology/approach
Using a non-probability convenience sampling technique, this study received 817 responses from consumers who regularly used global brands. Finally, this research examined 734 responses to test the proposed hypotheses using structural equation modeling.

Findings
This study discovered that perceived CSR authenticity strengthened perceived brand authenticity, which fostered perceived brand loyalty by enhancing brand trust and motivating consumers to spread PWOM about global brands. Similarly, perceived CSR authenticity directly influenced perceived brand loyalty by enhancing brand trust but did not affect PWOM. Likewise, the moderating effect of brand image was significant in fostering perceived brand loyalty by enhancing brand trust, but it had no effect on PWOM. In contrast, the brand image had a significant negative effect on perceived brand authenticity.

Practical implications
This research offered many insightful suggestions to global managers in the manufacturing and service industries that might assist them in designing and implementing several branding strategies to achieve corporate objectives.

Originality/value
This novel research contributes to the attribution theory by examining consumers’ perceptions of CSR authenticity, brand image, brand authenticity and brand loyalty from the global branding perspective.
Critical success factors for open source innovation in pharma industry: learning from two case studies
Authors: Jha Ajay , Sharma R.R.K. , Kumar Vimal 
Published: September 2022

PurposeThe study aims to add to the body of knowledge of open source tangible product management (also called open design). The objective is also to develop a guideline for efficient open source tangible product development and adoption.Design/methodology/approachThe exploratory research design using secondary data (like newspapers, magazines, research articles, bogs, papers, etc.) is used to analyze open source tangible product design challenges and enablers. The success stories of Open Source Software projects (OSS) were studied for identification of critical success factors and further their relevancy was tested in the two popular cases of open source drug discovery (malaria and tuberculosis)FindingsOpen innovation has become a part of competitive strategy of current businesses. It requires an efficient intellectual property protection regime for its implementation. However, in a market dominated by proprietary benefits, the open source technology development can serve as remedy for innovation needs of neglected sectors. The OSS literature revealed managing two classes of factors, namely technology sponsor level factors and environmental factors for efficiency and effectiveness. The case study analysis in the context of applicability of these OSS critical factors showed their limitations in open source tangible products, and highlighted understanding additional challenges and remedies.Research limitations/implicationsOpen source innovation is a collaborative effort involving inputs from various/diverse players, hence monitoring the effort and motivation level of the contributors is a cumbersome task. Only the information that is available online and in print media is taken as research inputs in this work. Also the data taken were from two case studies; a lot more case studies in the open design domain can progress the theory. The implications of this study are far-reaching in the areas where profit motivated proprietary efforts lack in addressing societal need. It provides guidelines for addressing those unmet needs by developing products in a collaborative way without intellectual property hurdles.Originality/valueThe essence of open design is becoming more vital, and there is a pressing need to build theory to support it, which still is elusive and dispersed. The study fills the gap using secondary data and case study approach.
The risk and prognostic factors for liver metastases in esophageal cancer patients: A large‐cohort based study
Authors: Luo Peng , Wei Xiufeng , Liu Chen , Chen Xiankai , Yang Yafan , Zhang Ruixiang , Kang Xiaozheng , Qin Jianjun , Qi Xiuzhu , Li Yin 
Published: September 2022

AbstractBackgroundThis retrospective study aimed to explore risk factors for liver metastases (LiM) in patients with esophageal cancer (EC) and to identify prognostic factors in patients initially diagnosed with LiM.MethodsA total of 28 654 EC patients were retrieved from the Surveillance, Epidemiology and End Results (SEER) database from 2010 to 2018. A multivariate logistic regression model was utilized to identify risk factors for LiM. A Cox regression model was used to identify prognostic factors for patients with LiM.ResultsOf 28 654 EC patients, 4062 (14.2%) had LiM at diagnosis. The median overall survival (OS) for patients with and without LiM was 6.00 (95% CI: 5.70–6.30) months and 15.00 (95% CI: 14.64–15.36) months, respectively. Variables significantly associated with LiM included gender, age, tumor site, histology, tumor grade, tumor size, clinical T stage, clinical N stage, bone metastases (BoM), brain metastases (BrM) and lung metastases (LuM). Variables independently predicting survival for EC patients with LiM were age, histology, tumor grade, BoM, BrM, LuM, and chemotherapy. A risk prediction model and two survival prediction models were then constructed revealing satisfactory predictive accuracy.ConclusionsBased on the largest known cohort of EC, independent predictors of LiM and prognostic indicators of survival for patients with LiM were identified. Two models for predicting survival as well as a risk prediction model were developed with robust predictive accuracy.
Reprograming of proteasomal degradation by branched chain amino acid metabolism
Authors: Ravanelli Sonia , Li Qiaochu , Annibal Andrea , Trifunovic Aleksandra , Antebi Adam , Hoppe Thorsten 
Published: September 2022

AbstractBranched‐chain amino acid (BCAA) metabolism is a central hub for energy production and regulation of numerous physiological processes. Controversially, both increased and decreased levels of BCAAs are associated with longevity. Using genetics and multi‐omics analyses in Caenorhabditis elegans, we identified adaptive regulation of the ubiquitin‐proteasome system (UPS) in response to defective BCAA catabolic reactions after the initial transamination step. Worms with impaired BCAA metabolism show a slower turnover of a GFP‐based proteasome substrate, which is suppressed by loss‐of‐function of the first BCAA catabolic enzyme, the branched‐chain aminotransferase BCAT‐1. The exogenous supply of BCAA‐derived carboxylic acids, which are known to accumulate in the body fluid of patients with BCAA metabolic disorders, is sufficient to regulate the UPS. The link between BCAA intermediates and UPS function presented here sheds light on the unexplained role of BCAAs in the aging process and opens future possibilities for therapeutic interventions.