bluuebunny/crossref_metadata_2025_split huggingface dataset:
An autonomous lunar geophysical experiment package (ALGEP) for future space missions
Authors: Kawamura Taichi , Grott Matthias , Garcia Raphael , Wieczorek Mark , de Raucourt Sébastien , Lognonné Philippe , Bernauer Felix , Breuer Doris , Clinton John , Delage Pierre , Drilleau Mélanie , Ferraioli Luigi , Fuji Nobuaki , Horleston Anna , Kletetschka Günther , Knapmeyer Martin , Knapmeyer-Endrun Brigitte , Padovan Sebastiano , Plesa Ana-Catalina , Rivoldini Attilio , Robertsson Johan , Rodriguez Sebastien , Stähler Simon C. , Stutzmann Eleonore , Teanby Nicholas A. , Tosi Nicola , Vrettos Christos , Banerdt Bruce , Fa Wenzhe , Huang Qian , Irving Jessica , Ishihara Yoshiaki , Miljković Katarina , Mittelholz Anna , Nagihara Seiichi , Neal Clive , Qu Shaobo , Schmerr Nicholas , Tsuji Takeshi 
Published: May 2022

AbstractGeophysical observations will provide key information about the inner structure of the planets and satellites and understanding the internal structure is a strong constraint on the bulk composition and thermal evolution of these bodies. Thus, geophysical observations are a key to uncovering the origin and evolution of the Moon. In this article, we propose the development of an autonomous lunar geophysical experiment package, composed of a suite of instruments and a central station with standardized interface, which can be installed on various future lunar missions. By fixing the interface between instruments and the central station, it would be possible to easily configure an appropriate experiment package for different missions. We describe here a series of geophysical instruments that may be included as part of the geophysical package: a seismometer, a magnetometer, a heat flow probe, and a laser reflector. These instruments will provide mechanical, thermal, and geodetic parameters of the Moon that are strongly related to the internal structure. We discuss the functionality required for future geophysical observations of the Moon, including the development of the central station that will be used commonly by different payloads.
Innovation in potentiometry: 3D-printed polylactic acid-based ion-selective bulk electrode membranes
Authors: Golcs Ádám , Vermes Brúnó , Siwek David Christopher , Huszthy Péter , Tóth Tünde 
Published: May 2022

AbstractAlthough ion-selective membrane-based potentiometric sensors have already proved their analytical performance in several fields of life, their applicability is still limited in practice. Biodegradable, ionic additive-free, polylactic acid-based bulk electrode membrane matrix containing various environmentally friendly polyethylene glycol derivatives as plasticizer was developed for the first time to replace the conventional PVC-based ones. Moreover, the first introduction of 3D printing in potentiometric chemosensing was also reported. It was demonstrated that a thoroughly optimized and generalizable procedure for filament extrusion combined with 3D printing technology provides a unique tool for series production of the redesigned ion-selective bulk electrochemical membranes. Finally, the potentiometric detection of Hg2+ in water was carried out as a proof-of-concept study on sensing. Results showed an unexpected improvement in electrochemical characteristics of the novel membranes compared to their conventional analogues. The present work expanded the practical applicability of conventional potentiometric cation-selective electrode membranes enabling their green, decentralized, and automated state-of-the-art manufacturing using a novel matrix composition.
Graphical abstract
Early Social Behavior in Young Children with Sex Chromosome Trisomies (XXX, XXY, XYY): Profiles of Observed Social Interactions and Social Impairments Associated with Autism Spectrum Disorder (ASD)
Authors: Bouw Nienke , Swaab Hanna , Tartaglia Nicole , Cordeiro Lisa , van Rijn Sophie 
Published: May 2022

AbstractIndividuals with Sex Chromosome Trisomies (SCT; XXX, XXY, XYY) have an increased vulnerability for developing challenges in social adaptive functioning. The present study investigates social interaction behavior in the context of varying social load, and Autism Spectrum Disorder (ASD) symptomatology in young children aged 1–7.5 years old, with SCT (N = 105) and control children (N = 101). Children with SCT show less interaction behaviors and more social withdrawal, as compared to their control peers, which were most evident in the high social load condition. Second, social impairments related to ASD are more prevalent, as compared to controls (27.1% at clinical level). These findings stress the importance of early monitoring and (preventive) support of early social development in young children with SCT.
A study of the inclusion complex formed between cucurbit[8]uril and isonicotinic acid
Authors: Yu Zhi-chao , Lu Yun , Shan Pei-hui , Fan Ying , Tao Zhu , Xiao Xin , Wei Gang , Prior Timothy J. , Redshaw Carl 
Published: May 2022

AbstractThe complexation between cucurbit[8]uril, Q[8], and isonicotinic acid has been studied using 1H NMR spectroscopy, UV–Vis absorption spectroscopy, Raman spectroscopy and single crystal X-ray diffraction. The results revealed that the 2:1 inclusion complex (4-PA)2@Q[8]·25H2O is formed, with two guests simultaneously encapsulated in the hydrophobic cavity; the mean planes of the guests are 3.535 Å apart.
Graphical abstract
The Broken Promise of Institutional Psychiatry: Sexuality, Women and Mental Illness in 1950s Lebanon
Authors: Moghnieh Lamia 
Published: May 2022

AbstractThis article traces the case of Hala, a woman chronic patient of the Lebanon Hospital for Mental and Nervous Disorders (LHMND) in late 1950s Lebanon. Her story reveals a conglomeration of actors, expertise and technologies that regulated both her sexuality and mental illness, as she was moved, returned, then moved again, from the care of the family to the care of the psychiatric institution. By reconstructing an ethnographic case of the story of Hala, the article tackles an under-investigated area of research at the intersection of subjectivity, sexuality, psychiatry and family life. The case of Hala illustrates an on-going tension in defining and diagnosing mental illness for women between two forms of care: institutional psychiatry on one hand—promising a quick return of patients to society—and the family on the other, with its own understandings of what constitutes abnormality for women. Having lived at the hospital for more than twenty years, Hala’s voice and experience provide a powerful contribution to the ethnographic history of psychiatry in Lebanon. The article tackles questions on competing psychiatric and social authorities and the formation of psychiatric subjectivities. It also provides methodological and ethical reflections on the use of archives when conducting ethnographic research on psychiatry from the global peripheries. The case of Hala illustrates the patient’s own experience of LHMND’s policies of social rehabilitation in the late 1950s. It adds to a broader understanding of the processes that have led to the pathologizing of sexuality in under-studied societies such as Lebanon and the Middle East.
Spatial and seasonal patterns of water use in Mediterranean coastal dune vegetation
Authors: Zunzunegui María , Esquivias M. Paz , Gallego-Fernández Juan B. 
Published: May 2022

Abstract

Aims
This paper examines the water dynamics of a coastal dune plant community, addressing spatial and seasonal variations. We aimed to detect the patterns of water use by plants at the community level according to their distribution across a coastal dune gradient from beach to inland.

Methods
Five sites were established: upper beach, embryo-dune, slack, foredune, and inland. Eight perennial species were collected seasonally to analyse the isotopic composition and water potential. Soil water samples at 3 depths, groundwater, and atmosphere, were obtained to determine plant water sources.

Results
The species from Inland and foredune plant communities, Retama, Juniperus, and Helichrysum, showed the most stable isotopic signal throughout the year. On the contrary, the species most abundant on the upper beach, embryo-dune, and slack (Ammophila, Achillea, and Polygonum) showed the highest variability. Water deficit decreased the dependence on shallow and mid-soil layers along the beach-inland gradient. Beach and embryo-dune sites showed less negative leaf water potential values than the other positions in the dune gradient.

Conclusions
Three factors mark the proportion of water sources used for vegetation in coastal vegetation: community composition, distance to the sea, and seasonality. Coastal dune vegetation exhibited a species-specific response in water uptake that was modified by its location on the gradient. From upper beach to inland, the plant communities showed a slight progressive increase in the use of water from deeper layers. This pattern was similar and overlapped with the wet to dry seasonal pattern.
Constraints to agroforestry diffusion under the Billion Trees Afforestation Project (BTAP), Pakistan: policy recommendations for 10-BTAP
Authors: Ullah Ayat , Zeb Alam , Saqib Shahab E. , Kächele Harald 
Published: May 2022

AbstractEffective agroforestry diffusion under the newly started 10-Billion Trees Afforestation Project (10-BTAP) needs a thorough understanding of the policy and implementation shortfalls of the already completed BTAP. This study examines the factors that affected the diffusion of the agroforestry in the Hindu-Kush Himalayan (HKH) region of Pakistan under BTAP. The data were gathered through in-depth interviews with Village Development Committee (VDC) members, Forest Department (FD) officials, and local farmers. Important factors positively affecting agroforestry diffusion included locations of crop fields on the river sides, community dependency on firewood, and market value of agroforestry timber. The logistic regression model shows that household head’s age, access to information, and area under cropland positively affected household level adoption of agroforestry under BTAP; forest cover was negatively related. In-depth interviews show that key barriers to FD in diffusion of agroforestry included provision of false information by farmers to monitoring teams, non-availability of extension staff, lack of communication among project staff and community, as well as a lack of sufficient budget for activities. Primary barriers to community adoption of agroforestry included no participation of VDCs in planning and monitoring of agroforestry programs, lack of plant need assessments on the part of the project staff, poor quality of plants distributed by FD, farmers’ poor know-how of plantations, lack of trust among community and project staff, as well as the waste of plants by farming community. Thus, this study recommends that policy-makers and project designers should consider these factors when planning agroforestry diffusion under 10-BTAP to improve its success.
Correlation between renal ablation zone in contrast-enhanced CT and non-enhanced MRI during the early period following percutaneous cryoablation
Authors: Umakoshi Noriyuki , Iguchi Toshihiro , Hiraki Takao , Matsui Yusuke , Tomita Koji , Uka Mayu , Kajita Soichiro , Araki Motoo , Mitsuhashi Toshiharu , Gobara Hideo , Kanazawa Susumu 
Published: May 2022

Abstract
Purpose
To retrospectively evaluate and correlate the contrast-enhanced computed tomography (CECT) and non-enhanced magnetic resonance imaging (MRI) during the early period following renal cryoablation.

Materials and methods
Both dynamic CECT and non-enhanced MRI were performed within 4 days following cryoablation in 34 renal tumors in 33 patients. The renal volumes of the unenhanced regions on dynamic CECT (nephrogenic phase, 4 mm thickness) and the regions with signal intensity changes on non-enhanced MRI (fat-suppressed T2-weighted image, 4 mm thickness) were evaluated. Fusion images of the axial, coronal, and sagittal sections of CECT and MRI images were created from the maximum cross-section of the renal tumor, and the match score of each image was visually evaluated on a 5-point scale.

Results
The mean renal volume of the unenhanced regions on CECT and those with signal intensity changes on non-enhanced MRI following cryoablation were 29.5 ± 19.9 cm3 (range, 4.3–97.4 cm3) and 30.7 ± 19.8 cm3 (range, 6.7–94.0 cm3), respectively; the difference between them was –1.17 cm3 (95% confidence interval [CI] –2.74, 0.40, P = 0.139). The Pearson’s product-moment correlation coefficient (r = 0.975; 95% CI, 0.951, 0.988; P < 0.0001) showed a strong correlation between the volumes. The average match score between CECT and non-enhanced MRI was as high as 4.5 ± 0.5 points (radiologist 1, 4.3 ± 0.5; radiologist 2, 4.7 ± 0.5). Local tumor control rate was 94.1% (32/34 tumors) and recurrence-free survival rate was 82.0% (95% CI: 64.2%, 91.5%) at 5 years.

Conclusions
The region with signal intensity changes on non-enhanced MRI was strongly correlated with the unenhanced region on CECT during the early period following renal cryoablation.
Addressing Peroxisome Proliferator-Activated Receptor-gamma in 3-Nitropropionic Acid-Induced Striatal Neurotoxicity in Rats
Authors: Mansour Riham M. , El Sayed Nesrine S. , Ahmed Maha A. E. , El-Sahar Ayman E. 
Published: May 2022

AbstractTelmisartan (TEL) is an angiotensin II type 1 receptor blocker and a partial activator of peroxisome proliferator-activated receptor-gamma (PPARγ), which regulates inflammatory and apoptotic pathways. Increasing evidence has demonstrated the PPARγ agonistic property of TEL in several brain disorders. This study aims to explore the neuroprotective impact of TEL in 3-nitropropionic acid (3-NP)-induced neurotoxicity in rats. The PPARγ effect of TEL was affirmed by using the PPARγ agonist pioglitazone (PIO), and the antagonist GW9662. 3-NP led to a significant reduction in body weight alongside motor and cognitive functioning. The striata of the 3-NP-treated rats showed energy-deficit, microglia-mediated inflammatory reactions, apoptotic damage as well as histopathological lesions. PIO and TEL improved motor and cognitive perturbations induced by 3-NP, as confirmed by striatal histopathological examination, energy restoration, and neuronal preservation. Both drugs improved mitochondrial biogenesis evidenced by elevated mRNA expression of PPARγ, PGC-1α, and TFAM, alongside increased striatal ATP and SDH. The mitochondrial effect of TEL was beyond PPARγ activation. As well, their anti-inflammatory effect was attributed to suppression of microglial activation, and protein expression of pS536 p65 NF-κB with marked attenuation of striatal inflammatory mediator's release. Anti-inflammatory cytokine IL-10 expression was concurrently increased. TEL effectively participated in neuronal survival as it promoted phosphorylation of Akt/GSK-3β, further increased Bcl-2 expression, and inhibited cleavage of caspase-3. Interestingly, co-treatment with GW9662 partially revoked the beneficial effects of TEL. These findings recommend that TEL improves motor and cognitive performance, while reducing neuronal inflammation and apoptosis in 3-NP-induced neurotoxicity via a PPARγ-dependent mechanism.
Graphical Abstract
A notable bounded probability distribution for environmental and lifetime data
Authors: Bakouch Hassan S. , Hussain Tassaddaq , Chesneau Christophe , Jónás Tamás 
Published: May 2022

AbstractIn this article, we introduce a notable bounded distribution based on a modification of the epsilon function that creates an upper bound on the domain of a distribution. Further, a key feature of the distribution is to have asymptotic connections with the famous Lindley distribution, which is a weighted variant of the exponential distribution and also a mixture of exponential and gamma distributions. In some ways, the proposed distribution provides a flexible solution to the modeling of bounded characteristics that can be almost well-fitted by the Lindley distribution if the domain is restricted. Moreover, we have also explored its application, particularly with reference to lifetime and environmental points of view, and found that the proposed model exhibits a better fit among the competing models. Namely, we demonstrate the practical applicability of the new distribution on two data sets containing lifetime data, as well as on two other data sets of rainfall data. Further, from the annual rainfall analysis, the proposed model exhibits a realistic return period of the rainfall.
A bi-objective blood supply chain model under uncertain donation, demand, capacity and cost: a robust possibilistic-necessity approach
Authors: Ghahremani-Nahr Javid , Kian Ramez , Sabet Ehsan , Akbari Vahid 
Published: May 2022

AbstractThis paper addresses a multi-objective blood supply chain network design, considering economic and environmental aspects. The objective of this model is to simultaneously minimize a blood supply chain operational cost and its logistical carbon footprint. In order to embed the uncertainty of transportation costs, blood demand, capacity of facilities and carbon emission, a novel robust possibilistic-necessity optimization used regarding a hybrid optimistic-pessimistic form. For solving our bi-objective model, three multi-objective decision making approaches including LP-metric, Goal-Programming and Torabi- Hassini methods are examined. These approaches are assessed and ranked with respect to several attributes using a statistical test and TOPSIS method. Our proposed model can accommodate a wide range of decision-makers’ viewpoints with the normalized objective weights, both at the operational or strategic level. The trade-offs between the cost and carbon emission for each method has been depicted in our analyses and a Pareto frontier is determined, using a real case study data of 21 cities in the North-West of Iran considering a 12-month implementation time window.
Analysis of clinical characteristics of children with Aicardi-Goutieres syndrome in China
Authors: Wang Wei , Wang Wei , He Ting-Yan , Zou Li-Ping , Li Wen-Dao , Yu Zhong-Xun , Ma Ming-Sheng , Yang Jun , Song Hong-Mei 
Published: May 2022

Abstract
Background
Aicardi-Goutieres syndrome (AGS) is an inflammatory disorder belonging to the type I interferonopathy group. The clinical diagnosis of AGS is difficult, which can lead to a high mortality rate. Overall, there is a lack of large-sample research data on AGS in China. We aim to summarize the clinical characteristics of Chinese patients with AGS and provide clues for clinical diagnostic.

Methods
The genetic and clinical features of Chinese patients with AGS were collected. Real-time polymerase chain reaction was used to detect expression of interferon-stimulated genes (ISGs).

Results
A total of 23 cases were included, consisting of 7 cases of AGS1 with three prime repair exonuclease 1 mutations, 3 of AGS2 with ribonuclease H2 subunit B (RNASEH2B) mutations, 3 of ASG3 with RNASEH2C, 1 of AGS4 with RNASEH2A mutations, 2 of AGS6 with adenosine deaminase acting on RNA 1 mutations, and 7 of AGS7 with interferon induced with helicase C domain 1 mutations. Onset before the age of 3 years occurred in 82.6%. Neurologic involvement was most common (100%), including signs of intracranial calcification which mainly distributed in the bilateral basal ganglia, leukodystrophy, dystonia, epilepsy, brain atrophy and dysphagia. Intellectual disability, language disability and motor skill impairment were also observed. Skin manifestations (60.87%) were dominated by a chilblain-like rash. Features such as microcephaly (47.62%), short stature (52.38%), liver dysfunction (42.11%), thyroid dysfunction (46.15%), positive autoimmune antibodies (66.67%), and elevated erythrocyte sedimentation rate (53.85%) were also found. The phenotypes of 2 cases fulfilled the diagnostic criteria for systemic lupus erythaematosus (SLE). One death was recorded. ISGs expression were elevated.

Conclusions
AGS is a systemic disease that causes sequelae and mortality. A diagnosis of AGS should be considered for patients who have an early onset of chilblain-like rash, intracranial calcification, leukodystrophy, dystonia, developmental delay, positive autoimmune antibodies, and elevated ISGs, and for those diagnosed with SLE with atypical presentation who are nonresponsive to conventional treatments. Comprehensive assessment of vital organ function and symptomatic treatment are important.
Sources and Fate of Organic Carbon in West Spitsbergen Fjord Systems: A Review
Authors: Saalim Syed Mohammad , Choudhary Shabnam , Mohan Rahul 
Published: May 2022

Abstract
Fjord margins in the high latitude regions are the hotspots for long term carbon burial. Studying the source and fate of organic carbon in high latitude fjords would help assess the sedimentary processes and burial. With the unprecedented warming, the marine productivity patterns are changing, leading to changes in the sources of organic carbon and its eventual burial in marine sediments. In the present study, high latitude fjords in the West Spitsbergen region has been reviewed, subjected to competing effects of large freshwater influx from the glacial melts, enhanced West Spitsbergen Current and its control on marine productivity. The West Spitsbergen Current advects warm North Atlantic waters enriched in nutrients to the fjords in the West Spitsbergen region. The increased freshwater from the glacial melts also dominates the fjords. Thus, the composition of organic matter in the fjord is mainly controlled by the inflow of freshwater from the glaciers and intrusion of oceanic waters to the fjords influencing the organic matter stability and carbon burial efficiency in the fjord sediments. The ongoing rapid warming in the Arctic changes the hydrographic settings, and changes in the strength of West Spitsbergen Current may also influence the long-term organic carbon burial in the West Spitsbergen fjords.
Improving Prospective Teachers’ Beliefs About a Double Discontinuity Between School Mathematics and University Mathematics
Authors: Eichler Andreas , Isaev Viktor 
Published: May 2022

AbstractProspective teachers often perceive a “double discontinuity” between school mathematics and university mathematics. The first discontinuity can be described as the belief that there is no coherence between school mathematics and university mathematics, which forms part of the notoriously problematic transition from school to university. The second discontinuity can be described as a belief about the lack of relevance of university mathematics for the later professional practice of prospective teachers. Beliefs about coherence and relevance have been known to impact prospective mathematics teachers’ interests and academic success. In this paper, we discuss an intervention involving 72 prospective secondary school mathematics teachers, aimed at influencing their beliefs about coherence and relevance. For this, we refer to the construct of beliefs as the main part of our theoretical framework, as well as the sub-constructs of beliefs regarding coherence and relevance. We then describe an intervention implemented within the first two years of mathematics courses, involving so-called “teacher-oriented” tasks that aim to trigger reflection on the benefit of university mathematics for teaching mathematics in school. The effect of the intervention was measured with a pretest-posttest experimental design using a questionnaire concerning teachers’ beliefs about coherence and relevance. Our results show that the prospective teachers’ beliefs about coherence and relevance generally decrease during the semester. However, statistically significant differences between the treatment group and a control group were found, especially regarding their beliefs about relevance.