bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypophosphatemia Due to Increased Effector Cell Metabolic Activity Is Associated with Neurotoxicity Symptoms in CD19-Targeted CAR T-cell Therapy
Authors: Tang Jack Pengfei , Peters Cole W. , Quiros Crystal , Wang Xiaoyan , Klomhaus Alexandra M. , Yamada Reiko E. , Timmerman John M. , Moore Theodore B. , Nowicki Theodore S. 
Published: October 2022

Abstract

A major complication of chimeric antigen receptor (CAR) T-cell therapy is immune effector cell–associated neurotoxicity syndrome (ICANS), which presents as aphasia, confusion, weakness, somnolence, seizures, and coma. This is similar to the neurologic manifestations of hypophosphatemia, which can result from sudden increases in metabolic demand for phosphorylated intermediates (e.g., refeeding syndrome and sepsis). Given these similarities, we investigated whether CAR T-cell effector metabolic activity is associated with increased extracellular phosphate consumption and a possible association between hypophosphatemia and ICANS. In vitro 4–1BB and CD28 CD19-targeted CAR T-cell effector activity was found to be associated with increased consumption of media phosphorus, which was temporally associated with increased single-cell effector secretomic activity and increased phosphorus-dependent metabolic demand of the CAR T cells. A clinical cohort of 77 patients treated with CD19-targeted CAR T-cell therapy demonstrated a significant anticorrelation between serum phosphorus and ICANS incidence and severity, with earlier onset of hypophosphatemia after CAR T-cell infusion more likely to result in neurotoxicity. These results imply phosphorous level monitoring could alert to the development of ICANS in clinical scenarios.
See related Spotlight by Tobin et al., p. 1422
Home Blood Pressure Can Predict the Risk for Stroke/Bleeding Events in Elderly Patients With Nonvalvular Atrial Fibrillation From the ANAFIE Registry
Authors: Kario Kazuomi , Hasebe Naoyuki , Okumura Ken , Yamashita Takeshi , Akao Masaharu , Atarashi Hirotsugu , Ikeda Takanori , Koretsune Yukihiro , Shimizu Wataru , Suzuki Shinya , Tsutsui Hiroyuki , Toyoda Kazunori , Hirayama Atsushi , Yasaka Masahiro , Yamaguchi Takenori , Teramukai Satoshi , Kimura Tetsuya , Morishima Yoshiyuki , Takita Atsushi , Inoue Hiroshi 
Published: October 2022

Background:
Blood pressure (BP) fluctuates significantly in patients with atrial fibrillation (AF); office BP measurements seem insufficient to assess AF patient risk accurately. We hypothesized that home BP could better predict the risk of stroke/systemic embolic events (SEE) and major bleeding in patients with AF than office BP.

Methods:
In this prespecified subcohort study of the ANAFIE (All Nippon AF in the Elderly) Registry, we evaluated the impact of home BP on the risk of stroke/SEE, major bleeding, intracranial hemorrhage, all-cause death, and net cardiovascular outcome (a composite of stroke/SEE and major bleeding). At enrollment, home BP was measured twice in the morning and evening for 7 days.

Results:
In total, 4933 elderly patients (aged ≥75 years) with nonvalvular AF participated. Incidences of net cardiovascular outcome, stroke/SEE, major bleeding, and intracranial hemorrhage increased significantly with increasing home systolic BP (H-SBP). Compared with H-SBP <125 mm Hg, ≥145 mm Hg was associated with increased risk of these events. The association between H-SBP and the events was observed only in patients with ≥20 H-SBP measurements.

Conclusions:
In elderly patients with nonvalvular AF, high H-SBP (≥145 mm Hg) was a significant predictor of stroke/SEE, major bleeding, and intracranial hemorrhage risk. Strict BP control guided by the increasing number of home BP measurements may provide an accurate clinical outcome risk assessment.

Registration:

URL:
https://www.umin.ac.jp/ctr
; Unique identifier: UMIN000024006
Subordinate submissive responses are predicted by dominant behaviour in a cooperatively breeding fish
Authors: Manara Veronica , Ruberto Tommaso , Swaney William T. , Reddon Adam R. 
Published: October 2022

Abstract
In complex social groups, animals rely on communication to facilitate priority access to resources and minimise the costs of conflict. Animals typically have more aggression signals than submission signals. However, some social species do show multiple submission signals, and the context in which these different signals are used is often not well understood. In the current study, we assessed agonistic interactions within groups of the cooperatively breeding daffodil cichlid fish (Neolamprologus pulcher) to investigate the relationship between the aggressive behaviours of the dominant breeding pair, and the submissive responses of the highest ranked subordinate within the group. Daffodil cichlids may respond to aggression by fleeing or by the production of either a tail quiver display or a head up display. Among the two submission signals, the tail quiver display was used more frequently in response to a threat display, while head up displays were produced approximately equally in response to both threat displays and overt aggression. An exaggerated version of the head up display was given more often in response to overt aggression, suggesting a graded submissive response both within and between the two submission signals. Within fish, the frequency of head up displays, but not tail quiver displays, correlated positively with the frequency of threat displays received. The current study helps us to better understand the use of submission signals in a highly social vertebrate and sheds light on submission as an understudied aspect of communication.
Decolonising the Theologico-Political Problem
Authors: Dube Siphiwe Ignatius 
Published: October 2022

Abstract
The theologico-political problem, traditionally concerned with the question of the seat of authority or sovereignty in the West (rendered through the metaphor of Jerusalem vs Athens or Revelation vs Reason), has been brought to the fore of late in a number of nation-states in Africa. To the end of rethinking the theologico-political problem or decolonising it, this article draws on Achille Mbembe’s notion of improvisation as an important avenue through which the decolonisation of the theologico-political problem can be situated meaningfully in the African context. Its core argument is that such a decolonisation of the theologico-political problem is not only useful for centering African experiences in political theology broadly, but also for further problematizing the decontextualized ways in which notions such as the theologico-political problem elide a history of “others” in their continued access primarily or even solely through Western experiences of state formation.
On the behavioural biology of a morpho-variant of Myrmaplata plataleoides (O. Pickard-Cambridge, 1869) (Araneae: Salticidae) with taxonomic notes
Authors: Kumar Rahul , Gupta Birendra Kumar , Sharma Ajay Kumar 
Published: October 2022

Abstract
We hereby report an isolated population of a rare morpho-variant of the ant-mimicking jumping spider Myrmaplata plataleoides (O. Pickard-Cambridge, 1869) from Hazaribagh Wildlife Sanctuary, Hazaribagh, Jharkhand, India, which is also the first record of this species from the state of Jharkhand, India. Descriptions of both male and female spiders, the female’s exuviae, its eggs and habitat are presented. We have studied its moulting, feeding and sexual behaviour in detail, and have recorded various behavioural aspects that were never documented before, such as debris-rolling behaviour, photokinetic response, starvation response and oxygen deprivation response. We here report the occurrence of this spider near the colonies of the ground-nesting ant Camponotus compressus (Fabricius, 1787). This spider is known to mimic the Asian weaver ant Oecophylla smaragdina (Fabricius, 1775), which are greenish orange to red in colour. Specimens collected by us are dark brown to black in coloration whereas the commonly reported specimens are often greenish orange to red. We propose that the darker coloration would have been naturally selected in this isolated population of M. plataleoides as an adaptation to coexist with C. compressus, which is also black in coloration and abundant around the spiders. Study of the moulting behaviour of the morpho-variant further reveals the display of a novel mechanism of ant mimicry among these spiders which we have named as temporal myrmecomorphy. Temporal myrmecomorphy has been proposed to be a protective mechanism used by a harmless mimic against the attacks of the aggressive models so that it can co-exist with the models. Present study establishes the usefulness of a morpho-variant as an important model in understanding the evolution and behaviour of a species holistically.
Evaluation of the Applicability of Three Methods for Climatic Spatial Interpolation in the Hengduan Mountains Region
Authors: Xu Xiaoming , Zhang Xueqin , Li Xiang 
Published: October 2022

Abstract
An ideal spatial interpolation approach is indispensable for obtaining high-quality gridded climatic data in mountainous regions with scarce observations, particularly for the Hengduan Mountains Region (HMR) with dense longitudinal ranges and gorges. However, there is much controversy about the applicability of thin plate smooth spline (TPSS), cokriging, and inverse distance weighting (IDW) in mountainous regions. Here, we use the daily observations of temperature and precipitation at 125 stations in HMR and its surroundings from 1961 to 2018 and adopt three interpolation methods to map the annual average temperature and precipitation at a resolution of 500 m in HMR. Then, we assess the applicability of three interpolation methods in HMR from the perspectives of interpolation accuracy and effects. The evaluation implies a satisfactory interpolation accuracy of TPSS with the highest correlation and lowest error, whether for temperature (R2 = 0.92, RMSE = 1.2°C) or precipitation (R2 = 0.54, RMSE = 165.9 mm). In addition, the TPSS could better display the temperature (precipitation) gradient along elevation and depict dry valleys’ high-temperature and low-precipitation characteristics. Moreover, the satisfactory interpolation performance of TPSS mainly benefits from the screening of optimal TPSS model that varied primarily with the regional topography feature and meteorological observation density. The uncertainty of gridded climate datasets has become an urgent problem to solve in the complex terrain. This research illustrates the satisfactory applicability of TPSS for climatic spatial interpolation in HMR, providing theoretical support for high-precision interpolation in complex terrain, hopefully improving the regional weather forecasts and disaster warnings.
A New Experimental Paradigm to Manipulate Risk in Human-Automation Research
Authors: Hoesterey Steffen , Onnasch Linda 
Published: October 2022

Objective Two studies serve as a manipulation check of a new experimental multi-task paradigm that can be applied to human-automation research (Virtual Reality Testbed for Risk and Automation Studies; ViRTRAS), in which a subjectively experienceable risk can be manipulated as part of a virtual reality environment. Background Risk has been postulated as an important contextual factor affecting human-automation interaction. However, experimental evidence is scarce due to the difficulty operationalizing risk in an ethical way. In the new paradigm, risk is varied by the altitude at which participants carry out the task, including the possibility of virtually falling in case of a mistake. Method Key components of the paradigm were used to investigate participants’ risk perception in a low (0.5 m) and high altitude (70 m) using subjective self-reports and objective behavioral measures. Results In the high-altitude condition risk perception was significantly higher with medium to large effect sizes. In addition, results of the behavioral measures reveal that participants habituated with length of exposure. However, this habituation seems to occur similarly in both altitude conditions. Conclusion The manipulation checks were successful. The new paradigm is a promising tool for automation research. It incorporates the contextual factor of risk and creates a situation which is more comparable to what real-life operators experience. Additionally, it meets the same requirements of other multi-task environments in human-automation research. Application The new paradigm provides the basis to vary the contextual factor of risk in human-automation research, which has previously been either neglected or operationalized in an arguably inferior way.
Effects of Initial Graft Tension and Patient Sex on Knee Osteoarthritis Outcomes After ACL Reconstruction: A Randomized Controlled Clinical Trial With 10- to 12-Year Follow-up
Authors: Costa Meggin Q. , Badger Gary J. , Chrostek Cynthia A. , Carvalho Orianna D. , Faiola Stacy L. , Fadale Paul D. , Hulstyn Michael J. , Gil Holly C. , Shalvoy Robert M. , Fleming Braden C. 
Published: October 2022

Background: The initial graft tension applied during anterior cruciate ligament (ACL) graft fixation may promote posttraumatic osteoarthritis (PTOA). Purpose/Hypothesis: This study sought to assess the effect of initial graft tension and patient sex on PTOA outcomes at 10 to 12 years after ACL reconstruction (ACLR). The hypothesis was that there would be no group- or sex-based differences in outcomes. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Patients were randomized to receive ACLR with a low or high initial graft tension. Outcomes were evaluated at 10 to 12 years postoperatively and compared with a matched, uninjured control group. Outcomes included clinical assessments (anteroposterior [AP] knee laxity measurement, International Knee Documentation Committee [IKDC] examination score), a functional assessment (single-leg hop for distance), patient-reported outcomes (Knee injury and Osteoarthritis Outcome Score [KOOS], 36-Item Short Form Health Survey, Tegner activity level, patient satisfaction), and PTOA imaging (Osteoarthritis Research Society International [OARSI] radiographic score and Whole-Organ Magnetic Resonance Imaging Score [WORMS]). Two-way mixed-model analyses of variance were used to evaluate differences in outcomes between tension groups and the control group and between female and male patients. Results: Both tension groups scored worse than the control group for the IKDC examination ( P≤ .021), KOOS (Pain, Activities of Daily Living, Sport/Recreation, and Quality of Life subscales) ( P≤ .049), and WORMS difference score ( P≤ .042). The low-tension group scored worse than the control group for KOOS Symptoms ( P = .016) and the OARSI difference score ( P = .015). The index limb had worse scores than the contralateral limb within the high-tension group for AP laxity ( P = .030) and hop deficit ( P = .011). This result was also observed within both tension groups for the WORMS ( P≤ .050) and within the low-tension group for the OARSI score ( P = .001). Male patients had higher Tegner scores (mean ± SE) relative to female patients (male, 5.49 ± 1.88; female, 4.45 ± 1.65) and worse OARSI difference scores (male, 1.89 ± 5.38; female, 0.244 ± 0.668) ( P = .007 and .034, respectively). However, no significant differences were detected between tension groups for any of the outcomes measured. Conclusion: Overall, ACLR failed to prevent PTOA regardless of initial graft tension. However, male patients treated with a low initial graft tension may be at greater risk for PTOA. These results do not support the hypothesis of no sex differences in outcomes at 10 to 12 years after ACLR.
Co-electrospun poly(vinyl alcohol)/poly(ɛ-caprolactone) nanofiber scaffolds containing coffee and Calendula officinalis extracts for wound healing applications
Authors: Doostan Mahtab , Doostan Maryam , Maleki Hassan , Faridi Majidi Reza , Bagheri Fariba , Ghanbari Hossein 
Published: October 2022

Fabrication of a biocompatible nanofibrous dressing with the advantage of the inclusion of bioactive herbal extracts is a promising approach in skin tissue engineering and wound healing applications. Herbal extracts possess many properties to promote the wound healing process, such as antioxidant properties, anti-inflammation activities as well as enhancing fibroblasts proliferation and migration. In this study, Calendula officinalis ( C. officinalis) and coffee extracts were loaded into poly(vinyl alcohol)/poly(ɛ-caprolactone) (PVA/PCL) nanofibrous mats. The obtained scaffolds were then characterized using scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared (ATR-FTIR), contact angle, and mechanical measurements. Also, the antioxidant activity, scratch assay, and cell viability of fibroblast cells were also evaluated. The results showed PVA/PCL scaffold loaded with 10 wt% C. officinalis and coffee extracts displayed smooth homogenous morphology with 317 ± 106 nm average diameter. Moreover, the relevant analyses confirmed that the extracts were incorporated into the nanofibers with suitable hydrophilicity and higher mechanical strength (4 ± 0.4 MPa). The antioxidant assay showed that IC50 values of coffee and C. officinalis extracts were 46 ± 1 ppm and 101 ± 4 ppm, successively, which presented a high antioxidant activity. The combination of both extracts showed a higher rate of migration than individual extracts with not detected cytotoxic effects on the human dermal fibroblast cells. In conclusion, our results confirmed that the coffee and C. officinalis extracts loaded PVA/PCL nanofibrous scaffolds could provide an appropriate construct for wound healing applications.
Dilemmas Related to Direct-Acting Oral Anticoagulant Administration in Patients With Extreme Obesity
Authors: Erstad Brian L. , Barletta Jeffrey F. 
Published: October 2022

Objective: The objective of the study was to discuss the controversies surrounding the use and dosing of direct-acting oral anticoagulants (DOACs) in obese patients recognizing the limitations of the existing evidence base that preclude strong recommendations. Data Sources: A literature search of MEDLINE was performed (2020 to end August 2022) subsequent to recent guidelines using the following search terms: direct acting anticoagulants, obesity, rivaroxaban, apixaban, edoxaban, dabigatran, dabigatran etexilate, and clinical practice guidelines. Study Selection and Data Abstraction: English-language studies and those conducted in adults were selected. Data Synthesis: The available randomized studies evaluating DOACs had relatively small numbers of patients with more extreme forms of obesity (body mass index [BMI] > 40 kg/m2) and none of the larger studies had a specific focus on dosing DOACs in obese patients. Recent guidelines by the International Society on Thrombosis and Haemostasis (ISTH) have specific recommendations for dosing DOACs in obesity. There are pharmacokinetic/pharmacodynamic and observational studies published before and after the ISTH guidelines with a focus on DOAC dosing in obese patients that generally support the recommendations in the guidelines, but most involved small numbers of patients usually with BMIs <45 kg/m2. Relevance to Patient Care and Clinical Practice: This review discusses DOAC dosing in obesity with important considerations for clinicians related to DOAC choice and dosing. Conclusions: Dosing alterations of DOACs do not appear to be necessary when used for either prophylaxis or treatment in patients with BMIs up to approximately 45 to 50 kg/m2, but research is needed for BMIs >50 kg/m2.
2022 ISFM/AAFP Cat Friendly Veterinary Environment Guidelines
Authors: Taylor Samantha , St Denis Kelly , Collins Sarah , Dowgray Nathalie , Ellis Sarah LH , Heath Sarah , Rodan Ilona , Ryan Linda 
Published: October 2022

Practical relevance: The ‘2022 ISFM/AAFP Cat Friendly Veterinary Environment Guidelines’ (hereafter the ‘Cat Friendly Veterinary Environment Guidelines’) describe how the veterinary clinic environment can be manipulated to minimise feline patient distress. Many components of a veterinary clinic visit or stay may result in negative experiences for cats. However, much can be done to improve a cat’s experience by making the veterinary clinic more cat friendly. Exposure to other cats and other species can be reduced, and adjustments made with consideration of the feline senses and species-specific behaviour. Caregivers can prepare cats for a clinic visit with appropriate advice. Waiting rooms, examination rooms, hospital wards and other clinic areas can be designed and altered to reduce stress and hence encourage positive emotions. Changes need not be structural or expensive in order to be effective and make a difference to the cats and, in turn, to cat caregivers and the veterinary team. Moreover, by improving the all-round experience at the veterinary clinic, there are positive effects on preventive healthcare, identification of and recovery from illness, and compliance with treatment. Clinical challenges: Good feline healthcare necessitates visiting the veterinary clinic, which, simply by being outside of a cat’s territory and familiar surroundings, may lead to negative experiences. Such experiences can trigger negative (protective) emotions and associated physiological stress, which can result in misleading clinical findings, patient distress, prolonged recovery from illness, further difficulties with handling at subsequent visits and potential veterinary personnel injury. There may be a mistaken belief that veterinary clinics must undergo significant renovation or building work to become cat friendly, and that, if species cannot be separated, then clinics cannot improve their care of cats. These Guidelines aim to dispel any such misconceptions and provide detailed practical advice. Evidence base: These Guidelines have been created by a Task Force of experts convened by the International Society of Feline Medicine and American Association of Feline Practitioners, based on an extensive literature review and, where evidence is lacking, the authors’ experience. Endorsements: These Guidelines have been endorsed by a number of groups and organisations, as detailed on page 1161 and at icatcare.org/cat-friendly-guidelines and catvets.com/environment .
Experiences of carers of youth, adult children and spouses with ME/CFS
Authors: Baken Don M , Ross Kirsty J , Hodges Lynette D , Batten Lesley 
Published: October 2022

Objectives The debilitating nature of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) means that family members often take on a caring role. This study compared the experiences of people caring for three groups: youth, young adults, spouses. Methods An opportunistic sample of 36 carers completed an online survey of open-ended questions asking about their experiences. Thematic analysis was used to consider the three sets of responses separately and Thematic Comparison was used to identify points of connection and disconnection across the sets. Results The themes identified were very similar to those identified in past studies. Two super-ordinate themes were identified: “Lack of knowledge and understanding” and “Holistic Impact”. Though most sub-ordinate themes were evident across all three groups, important differences were found. The sub-ordinate themes “Caring Blindly”, “Emotional and physical health cost”, and “Impact on the whole family” were more evident amongst carers of youth while the theme “Worry for the future” was more evident from carers of young adults and spouses. Discussion Differences seemed to be related to both the time since diagnosis and the life stage. A longitudinal study would help to understand how carer experiences change over the life course of caring for someone with ME/CFS.