bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted Plasma Proteomics to Predict the Development of Carotid Plaques
Authors: Baragetti Andrea , Mattavelli Elisa , Grigore Liliana , Pellegatta Fabio , Magni Paolo , Catapano Alberico Luigi 
Published: July 2022

Background:
Cardiovascular risk stratification in primary prevention is a clinical challenge. We recently identified a large set of circulating proteins improving the risk prediction for cardiovascular events. We now evaluate which of these proteins predicts the development of subclinical carotid atherosclerosis (SCA) in primary cardiovascular prevention.

Methods:
Three hundred sixty-eight proteins were quantified, by proximity extension assay, from the plasma collected at basal visit from 586 subjects without previous cardiovascular events and without preclinical atherosclerosis. These subjects were reevaluated 11 years after median follow-up (10–12) in a longitudinal observational analysis, to assess the development of SCA, defined as the formation of focal lesion in any carotid tract and detected by carotid ultrasound at basal visit and after follow-up. Common carotid (intima-media thickness [IMT]) was also measured by ultrasound during the same follow-up to identify subjects with faster common carotid intima-media thickness (IMT) progression (increase IMT)>1.3 mm in the common carotid tract).

Results:

The variation of 68 proteins predicted SCA development and, among them, higher levels of PIgR2 (polymeric immunoglobulin receptor), chemokine (C-C motif) ligand 18, CA1 (carbonic anhydrase 1), Fc gamma receptor IIa and reduced MMP10 (matrix metallopeptidase 10), GT (gastrotropin), IL7R (interleukin 7 receptor) were the most predictive for SCA development. These 7 proteins improved the sensitivity and the specificity for SCA development versus risk factors (age, sex, overweight, hypertension, low HDL-cholesterol, high triglyceride); area under the curve: 0.747 ([0.707–0.784] versus 0.620 [0.577–0.663];
P
<0.001). Vice versa, 25 proteins (not in common with the previous 68) predicted faster common carotid IMT progression. Among them, increased IL7D (interleukin 7), chemokine (C-X-C motif) ligand 1, and reduced TNFS13B (TNF superfamily member 13b) significantly increased the sensitivity and the specificity to predict faster common carotid IMT progression as compared with same risk factors (area under the curve: 0.719 [0.680–0.756] versus 0.569 [0.527–0.610];
P
<0.001).

Conclusions:
A new set of circulating proteins have been identified that may be considered as markers of preclinical atherosclerosis development. The difference of the protein identified to predict SCA versus IMT progression may reflect different etiological factors.
On the Politics of Design Framing Practices
Authors: Prendeville Sharon , Syperek Pandora , Santamaria Laura 
Published: July 2022

Abstract
In this conceptual article, our aim is to deconstruct the conceptualization of design framing and establish its essentially political nature. It demonstrates the positionality inherent within frames insofar as frames articulate subordinated or dominant status, or express normative understandings until challenged. In doing so, we build a conceptualization of the political foundations of design framing practices and their implications for those contexts within which design operates. Consequently, we argue for dissensual counter-framing design practices that unsettle institutionalized norms and ideologies played out within frames, and through which a form of political agency is sociomaterially enacted.
Evaluation of Independent Stochastically Perturbed Parameterization Tendency (iSPPT) Scheme on HWRF-Based Ensemble Tropical Cyclone Intensity Forecasts
Authors: Zhao Xiaohui , Torn Ryan D. 
Published: July 2022

Abstract
Tropical cyclone (TC) intensity has been shown to have limited predictability in numerical weather prediction models; therefore, ensemble forecasting may be critical. An ensemble prediction system (EPS) should ideally cover all sources of uncertainty; however, most meso- and convective-scale EPSs typically consider initial-condition uncertainty alone, with limited treatment of model uncertainty, even though the evolution of mesoscale features is highly dependent on uncertain parameterization schemes. The role of stochastic treatment of model error in the Hurricane Weather Research and Forecasting (HWRF) EPS is evaluated by applying independent stochastically perturbed parameterization (iSPPT) scheme to individual parameterization schemes for four TCs from 2017 to 2018. Experiments with Hurricane Irma (2017) indicate that TC intensity ensemble standard deviation is most sensitive to the amplitude of the stochastic perturbation field, with smaller impact from adjusting the decorrelation time scale and spatial length scale. Results from all four TC cases show that stochastic perturbations to the turbulent mixing scheme can increase the ensemble standard deviation in intensity metrics over a 72-h simulation without introducing significant differences in mean error or bias. By contrast, stochastic perturbations to the microphysics, radiation, and cumulus tendencies have negligible effects on intensity standard deviation.
Transcriptome analysis of the response to low temperature acclimation in Calliptamus italicus eggs
Authors: Liu Qian , Luo Di , Wang Mengjia , Song Xingmin , Ye Xiaofang , Jashenko Roman , Ji Rong 
Published: July 2022

Abstract
Background
Calliptamus italicus is a dominant species in the desert and semi-desert grassland. It is widely distributed throughout many regions such as Asia, Europe, North Africa and the Mediterranean, and has enormous destructive potential for agriculture and animal husbandry. The C. italicus overwintering as eggs in the soil through diapause, and the cold tolerance of locust eggs is the key to their ability to survive the winter smoothly to maintain the population.

Results
Transcriptome analysis of C. italicus eggs was carried out in this paper in constant low temperature acclimation, natural low temperature acclimation and room temperature. The differentially expressed genes related to cold tolerance were screened out, the differences in expression patterns under different low temperature acclimation were analyzed, and the genes in the significantly up-regulated pathways may play an important role in cold tolerance. The results show that different domestication modes can induce C. italicus eggs to express a large number of genes to alleviate low temperature damage, but C. italicus eggs are more sensitive to changes in temperature. Compared with the control, there are 8689 DEGs at constant low temperature and 14,994 DEGs at natural low temperature. KEGG analysis showed that DEGs were mainly enriched in pathways related to metabolism and biological systems under constant low temperature, and were mainly enriched in pathways related to biological systems and environmental information processing under natural low temperature. In addition, RNAi technology was used to further verify the regulation of genes in the significantly enriched up-regulated pathways on C. italicus eggs, and it was confirmed that the hatching rate of C. italicus eggs at low temperature was significantly reduced after interference.

Conclusions
Transcriptome analysis of C. italicus eggs treated at different temperatures provided a theoretical basis for further understanding the adaptation mechanism of C. italicus eggs to low temperature. In addition, four potential RNAi target genes were verified in the eggs of C. italicus for the first time, providing new ideas for effective control of this species.
Pragmatic solutions to enhance self-management skills in solid organ transplant patients: systematic review and thematic analysis
Authors: Abtahi Hamidreza , Safdari Reza , Gholamzadeh Marsa 
Published: July 2022

AbstractBackgroundIn organ transplantation, all patients must follow a complex treatment regimen for the rest of their lives. Hence, patients play an active role in the continuity of the care process in the form of self-management tasks. Thus, the main objective of our study was to investigate the pragmatic solutions applied by different studies to enhance adherence to self-management behaviors.MethodA systematic review was conducted in five databases from 2010 to August 2021 using keywords. Eligible studies were all English papers that developed self-management programs to enhance patient care in solid organ transplantation. The interventions were analyzed using thematic analysis to determine the main descriptive areas. The quality of the included articles was evaluated using the research critical appraisal program (CASP) tool.ResultsOf the 691 retrieved articles, 40 met our inclusion criteria. Of these, 32 studies were devoted to the post-transplantation phase. Five main areas were determined (e-health programs for telemonitoring, non-electronic educational programs, non-electronic home-based symptom-monitoring programs, electronic educational plans for self-monitoring, and Telerehabilitation) according to thematic analysis. Most studies (72.5%) declared that developed programs and applied solutions had a statistically significant positive impact on self-management behavior enhancement in transplant patients.ConclusionThe results showed that an effective solution for improving organ transplantation needs patient collaboration to address psychological, social, and clinical aspects of patient care. Such programs can be applied during candidate selection, waiting list, and after transplantation by putting the patient at the center of care.
Extramedullary relapse of acute myeloid leukemia in brachial plexus after allogeneic stem cell transplantation: a case report
Authors: Shirota Shogo , Katoh Daisuke , Shimomura Yoshimitsu , Imai Yukihiro , Ishikawa Takayuki 
Published: July 2022

AbstractBackgroundAllogeneic hematopoietic stem cell transplantation is a potentially curative treatment for acute myeloid leukemia. However, extramedullary relapse of acute myeloid leukemia can occur after hematopoietic stem cell transplantation, causing treatment failure. Extramedullary relapse rarely involves the peripheral nerves, and it is not influenced by the effect of the graft on leukemia.Case presentationWe report a case of extramedullary relapse of acute myeloid leukemia in the brachial plexus of a 41-year-old woman treated with allogeneic hematopoietic stem cell transplantation (HSCT). Complete hematological remission was confirmed by bone marrow examination 1 month after HSCT, and she developed no major complications immediately after HSCT. The immunosuppressant was discontinued 5 months later. However, 2 weeks after immunosuppressant withdrawal, the patient developed left arm pain and paresthesia, with subsequent development of a mass in the left brachial plexus. She was initially diagnosed with brachial plexus neuropathy because of concomitant graft-versus-host disease. Despite the administration of immunosuppressive agents, the mass continued to enlarge. The biopsy of the lesion revealed leukemic relapse. Thus, the patient was diagnosed with extramedullary relapse and underwent radiotherapy, resulting in tumor shrinkage.ConclusionExtramedullary relapse should be considered a differential diagnosis in post-transplant patients with leukemia presenting with paresthesia.
Associations between comorbidities and annual incidence plus frequency of asthma exacerbation hospitalisation during the past year: data from CARN study
Authors: Wang Wenqiao , Lin Jiangtao , Zhou Xin , Wang Changzheng , Huang Mao , Cai Shaoxi , Chen Ping , Lin Qichang , Zhou Jianying , Gu Yuhai , Yuan Yadong , Sun Dejun , Yang Xiaohong , Yang Lan , Huo Jianmin , Chen Zhuochang , Jiang Ping , Zhang Jie , Ye Xianwei , Liu Huiguo , Tang Huaping , Liu Rongyu , Liu Chuntao , Zhang Wei , Hu Chengping , Chen Yiqiang , Liu Xiaoju , Dai Luming , Zhou Wei , Huang Yijiang , Xu Jianying 
Published: July 2022

AbstractPurposeWhile asthma comorbidities are associated with higher health care utilisation, lower quality of life and poorer asthma control, the impact of asthma comorbidities on hospitalisation for asthma exacerbation (H-AX) remains less recognised. We aim to analyse the impact of asthma comorbidities on H-AX.MethodsBased on a national survey on asthma control and disease perception (CARN 2015 study), we analysed the impact of comorbidities on annual incidence and frequency of H-AX in China. Information on demographic characteristics, asthma comorbidities and annual incidence and frequency of H-AX were presented in this study.ResultsAmong 3875 ambulatory asthma patients, 75.9% (2941/3875) had comorbidities, and 26.4% (1017/3858) experienced H-AX during past year. After adjusting for confounding factors such as demographic data, smoking status and asthma control, COPD [OR = 2.189, 95% CI (1.673, 2.863)] and coronary heart disease [OR = 1.387, 95% CI (1.032, 1.864)] were associated with higher annual incidence, while allergic rhinitis [OR = 0.692, 95% CI (0.588, 0.815)] was associated with lower annual incidence, of H-AX. In terms of frequency, allergic rhinitis [OR = 1.630, 95% CI (1.214, 2.187)], COPD [OR = 1.472, 95% CI (1.021, 2.122)] and anxiety [OR = 2.609, 95% CI (1.051, 6.477)] showed statistically significant correlation with frequent H-AX.ConclusionsCOPD and coronary heart disease were associated with higher annual incidence, while allergic rhinitis was associated with lower annual incidence of H-AX. Allergic rhinitis, COPD and anxiety were associated with frequent H-AX. Comorbidities may have an important role in the risk and frequency of annual hospitalisations due to asthma exacerbation. The goal of asthma control should rely on a multi-disciplinary treatment protocol.
Disaster response among hospital nurses dispatched to evacuation centers after the Great East Japan Earthquake: a thematic analysis
Authors: Yamamoto Chika , Yamada Chieri , Onoda Katsuko , Takita Morihito , Kotera Yasuhiro , Hasegawa Arifumi , Oikawa Tomoyoshi , Tsubokura Masaharu 
Published: July 2022

Abstract
Background
Disaster relief operations involve a variety of components of healthcare efforts. The post-disaster recovery is a key component of hospital preparedness. This study aimed to investigate the role of hospital nurses in the disaster area and their challenges during the relief efforts after the Great East Japan Earthquake in 2011.

Methods
Semi-structured interviews were conducted with ten nurses who worked in a general public hospital before the Great East Japan Earthquake and were dispatched to the evacuation centers after the disaster. A qualitative approach with the thematic analysis method was employed. Three research queries (RQs) were prepared before the interview.

Results
The study participants played administrative roles as city employees in addition to performing nursing services as healthcare providers in evacuation centers. The first RQ on their challenges in evacuation centers gave us four themes: criticism by the evacuees, conflicts between multiple roles, difficulties in performing the first experience, and anxiety in working. The second RQ asking about motivation to accomplish disaster relief efforts raised three themes of carrying out the nursing role, acceptance by evacuees, and strengths of human connections. Two themes of awareness of disaster medicine and professional growth were raised from the third RQ of gains from the experiences in the evacuation centers.

Conclusions
The hospital nurses in the disaster area performed multiple roles in the relief efforts in the evacuation centers, which developed a psychological burden on them. A sense of competence supported the motivation to accomplish the disaster relief activities and professional growth as a specialist in disaster medicine. A study limitation is missing hospital nurses who resigned during the relief efforts. Further study is warranted to refine the disaster preparedness of hospital operations.
Pulmonary actinomycosis mimicking lung cancer on 18F-fluorodeoxyglucose positron emission tomography: a case report
Authors: Miyazaki Shinichi , Fujito Takeo , Kondo Yuki , Kuno Yasumasa , Mori Shunsuke , Yamashita Ryo , Ishida Junzo , Nara Yoshiharu , Ikeda Takuya 
Published: July 2022

Abstract
Background
Pulmonary actinomycosis is a chronic disease characterized by abscess formation, draining sinuses, fistulae, and tissue fibrosis. It can mimic other conditions, particularly malignant and granulomatous diseases, and is perhaps extremely challenging to diagnose.

Case presentation
A 64-year-old Japanese man presented with 6-week history of a painful solid lump in the chest wall. Chest computed tomography scan revealed a mass-like consolidation in the left upper lobe, with rib erosion and direct extension into the anterior chest wall. 18F-fluorodeoxyglucose positron emission tomography scan showed increased metabolic activity in the mass, which is indicative of primary lung cancer. The bronchoscopy and computed tomography scan-guided transthoracic biopsy results were considered nondiagnostic. Finally, the patient was diagnosed with pulmonary actinomycosis via surgical resection. He completed an 8-week course of antibiotic therapy and experienced no recurrence.

Conclusions
There is no difference in positron emission tomography/computed tomography scan findings between actinomycosis and malignancy. Therefore, pulmonary actinomycosis should be considered in the differential diagnosis of cases involving intensive activity on 18F-fluorodeoxyglucose positron emission tomography scan.
Women’s lifetime reproductive profiles and frailty among aging individuals in the USA and the Philippines
Authors: Escasa-Dorne Michelle , Zoorob Ronza 
Published: July 2022

AbstractFrailty, particularly traits which are related to sex steroid hormone production, results from the age-associated decline in function considered to be part of the typical aging process. This process may vary with influences including environmental, biological, or lifestyle factors. An area of concern that has received relatively little attention is the impact of cumulative lifetime changes in sex steroid hormones related to the traits we see that typify the human aging process. Women’s lifetime reproductive profiles include menstrual/ovulatory cycles, gestation, and lactation, all of which respond to changes in sex steroid hormone levels. Here, we review data on reproductive profiles and risks of frailty among post-menopausal women. In the current study, our team collected reproductive histories of women to determine the estimated number of lifetime reproductive cycles (ELC). We interviewed 44 women in the USA and 67 women in the Philippines aged 65 years plus to obtain data on reproductive cycles, pregnancy, and breastfeeding. Participants completed several frailty tasks including grip strength, a sit-to-stand test, and gait speed. While ELC was not associated with frailty in the US population, higher ELC was associated with lower frailty among the Philippine population. The current study should be considered as an exploratory project investigating field-friendly methods to use when considering lifetime reproductive histories and the influence on the aging process.
Imported cases of cutaneous leishmaniasis in Cuba, 2017: role of human movement
Authors: Monzote Lianet , González Daniel , Blanco Orestes , Fraga Jorge , Capó Virginia , Herrera Alberto , Montalvo Ana Margarita 
Published: July 2022

AbstractBackgroundLeishmaniasis is a vector-borne disease caused by several species from genusLeishmania. An increase in the number of cases related to human movement has been informed in the last years. Due to the increase of suspicious leishmaniasis cases arriving in Cuba during 2017, a general analysis is presented herein.MethodsClinical samples were collected from 5 patients suspicious of leishmaniasis, received from January to December 2017 at the Institute of Tropical Medicine Pedro Kourí, Cuba. Skin lesion samples were analyzed using different diagnostic assays: direct smear, histological examination, and molecular analysis for species identification. Epidemiological and demographic data were requested from each case and analyzed. Treatment and follow up of patient was also performed.ResultsFive cases were confirmed asLeishmaniainfection according to microscopic observation and molecular methods results. PCR-18S, PCR-N/RFLP and PCR-F/RFLP identified the following species:L. panamensis(2 cases),L. braziliensis(1 case),L.panamensis/L.guyanensis(1 case),L. mexicanacomplex (1 case). In treated patients, drugs were well tolerated, cure were documented and no relapse have been currently reported (3 years later).ConclusionsClinical characteristics, demographic data, and epidemiological features of infection for each case evidence the potential risk related with travel to endemic areas of leishmaniasis.KeyworksCutaneous leishmaniasis, Epidemiology, Imported cases.
Grasses are able to harbor the oversummering of urediospores and the overwintering of teliospores of Puccinia striiformis f. sp. tritici in China
Authors: Qin Jianfeng , Wang Zhiyan , Lv Yanjie , Kang Zhensheng , Zhao Jie 
Published: July 2022

AbstractPuccinia striiformis f. sp. tritici (Pst), the cause of wheat stripe rust, is a biotrophic and heteroecious rust fungus with five spore types. Cool and humid climatic conditions are conducive for the development of wheat stripe rust, and in turn, temperatures above 22 °C limit or even cease the disease. The survival of Pst during summer after wheat harvest is responsible for the infection on autumn-sown wheat to maintain disease cycle all the year round. Teliospores formed at late stage of wheat growth are essential for initiating sexual reproduction in spring. Although Chinese native grasses have been experimentally testified as susceptible hosts for Pst and teliospores produced on wheat have been shown to be potential inoculum sources causing infection on alternate hosts (mainly Berberis) in spring, the roles of grass hosts in harboring the survival of urediospores and teliospores of Pst and promoting the emergence of diverse races under field conditions in China have not been known. Herein, Gansu, as a hotspot and an important oversummering region for Pst, was exemplified to demonstrate these roles of grass hosts. As a result, 63 Pst isolates, derived from 2184 uredial samples collected from grass hosts during harvesting period (from mid-June to mid-to-late July) and seeding period (mid to late September) in 2012 and 2013, were identified as 52 diverse phenotypes (82.5%) on the Chinese differential hosts. Subsequently, after inoculation of barberry, 52 Pst isolates with high infection type, 20 known races and 32 new races, were recovered from 1,712 single aecium, which are derived from 35 telial samples of grass hosts. Our experiments showed that Pst urediospores can oversummer on grass species in Gansu or other oversummering regions with similar ecological and climatic conditions. Pst teliospores, which are produced on these grass hosts, are important inoculum source for barberry infection in spring. Therefore, treatment of grasses hosts should be taken into consideration in management of wheat stripe rust.