bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green Synthesis of Mono, Bis and Tris Aminobenzochromenes and Benzopyranochromenes
using Fe3O4@Sio2@ Vanillin/Vitamin B1 Nanoparticles:
A New, Mild, Simple and Effective Bronsted Acid Catalyst for the Synthesis
of Chromenes
Authors: Fekri Leila Zare , Kadivar-Kalmarzi Mohaddeseh , Hojjati-Zolpirani Zahra 
Published: August 2022

Objective:
Vanillin/Vitamin B1 (Thiamine) supported Fe3O4@SiO2 nanoparticles (Fe3O4 @SP@VT) were synthesized and thoroughly analyzed, and was used for the green and efficient synthesis of chromenes using the multicomponent reaction of aldehyde, malononitrile and 4-hydroxy coumarin, as well as the multicomponent reaction of aldehyde, α-naphthol or β–naphthol and 4-hydroxy coumarin.

Methods:
The reaction was performed under grinding conditions and at the end of the reaction the catalyst was separated in the presence of a strong magnet and can be recovered 10 times.

Results:
The advantages of this method are high purity of products, short times, higher yield, easy separation and cheap raw materials.

Conclusion:
we have developed Fe3O4@SP@VT catalyzed multicomponent synthesis of aminobenzochromenes using the reaction of benzaldehyde, malononitrile and naphthol and multicomponent synthesis of benzopyranochromenes using benzaldehyde, 4-hydroxycoumarin and β-naphthol under grind technique.
Comprehensive Metabolomic Analysis of Lung Cancer Patients Treated
with Fu Zheng Fang
Authors: Ding Yongjuan , Lv Juan , Hua Yujiao 
Published: August 2022

Background:
Lung cancer remains one of the leading cancers with increasing mortality rates in the world, the clinicians in our hospital summarized “Fu Zheng Fang (FZF)” as Chinese medicine prescription with good therapeutic effect and low adverse reactions to treat lung cancer.

Objective:
To give an in-depth study on the essence and internal rules of the effect of FZF.

Method:
Serums samples from twenty lung cancer patients and whom accepted FZF were subjected to metabolomic profiling using UPLC-Q-Exactive-MS combined with multivariate statistical analysis.

Result:
17 significantly differential metabolites were found in NC and FZF group, which were mainly participated in phenylalanine metabolism, apelin signaling pathway, sphingolipid signaling pathway, and others. Seven metabolites were increased in FZF group relative to NC group, while ten metabolites were decreased in FZF group, most of them were proved to be consistent with previous experiments. This indicated that FZF had a definite therapeutic effect on lung cancer by regulating the contents of metabolites through amino acid metabolism, metabolism of cofactors and vitamins, carbohydrate metabolism, and cancer.

Conclusion:
This study provides a deeper insight into the comprehensive understanding of molecular mechanisms of FZF treatment against lung cancer.
Cyclodextrin based Nanosponges for the Oral Delivery of Actarit:
Physicochemical Characterisation and Dissolution Studies
Authors: Madhavi M. , Kumar G.S. 
Published: August 2022

Introduction:
The current research aims to formulate a controlled release formulation of
Actarit utilizing cyclodextrin based nanosponges as a nanocarriers. β-Cyclodextrin built nanosponges
were prepared by condensation reaction using diphenyl carbonate as crosslinking agent.

Method:
A 3-level, 3-factor Box-Behnken design was used to optimize the reaction conditions. The
particle size, zeta potential and solubilization efficiency of prepared nanosponges were determined.
Actarit was loaded into nanosponges by freeze drying method. Actarit loaded nanosponges were
further evaluated for particle size, zeta potential, surface morphology, FTIR, DSC, XRD and
Dissolution characteristics. The cyclodextrin nanosponges prepared under optimum conditions exhibited
a particle size range of 143.42 to 152.76 nm with low polydispersity indices. FTIR spectra confirmed
the formation of carbonyl bond between the β-Cyclodextrin molecules.

Results and Discussion:
Actarit loaded nanosponges exhibited a particle size range of 157.13 to
168.34 nm with minimum polydispersity index. The zeta potential value was sufficiently high to maintain
the stability of colloidal nanosponges. TEM image exposed the spherical structure of drug loaded
nanosponges that could be retained and released gradually over time. The FTIR, DSC and XRPD
studies inveterate the interaction between Actarit and nanosponges. The drug loaded nanosponges
displayed a significant progress in dissolution of drug when compared to plain Actarit. The initial rapid
release of Actarit from nanosponges formulations was observed. After 24 h of study, around 90 % of
the drug released from nanoformulation and only around 20 % of the drug from free drug suspension.

Conclusion:
Cyclodextrin based nanosponges displayed superior complexing capability with increased
solubility of poorly soluble Actarit.
Applications of Bacteriocins of Lactic Acid Bacteria in Biotechnology and Food Preservation: A Bibliometric Review
Authors: Anumudu Christian K. , Omoregbe Osaze , Hart Abarasi , Miri Taghi , Eze Ukpai A. , Onyeaka Helen 
Published: August 2022

Introduction:
Due to the growing prevalence of antibiotic resistance in microorganisms and the demand for safe food, there is increasing interest in using natural bioproducts such as the antimicrobial peptides bacteriocins to extend the shelf-life of foods. This is because of their spectrum of activity, ease of synthesis and applicability. This study reports on the global trends in lactic acid bacteria (LAB) bacteriocins based research publications in the Web of Science core collections within the last 20 years (2000-2019), with specific focus to their applications in biotechnology and food science.

Methods:
Data analysis was undertaken using VOSviewer and HistCite software to evaluate relationships between articles and visualise research linkages amongst authors, institutions and countries.

Results:
In the 20 years under review, a total of 1741 bacteriocin related articles were published, with the most cited publication examining the anti-infective activity of Lactobacillus salivarius. The highest research output was recorded by the United States, followed by Spain and China. However, Europe as a continent had the highest research output with a higher inter-institution collaboration network and stronger food safety legislations.

Discussion:
The bibliometric analysis gave insights into the research areas, cooperation network of authors, co-citation maps and co-occurrence of keywords utilized in the research field and indicates that bacteriocin-based research is highly multidisciplinary with a global reach.

Conclusion:
Key focus is on the control of foodborne disease pathogens, search for new producer organisms and approaches to improve bacteriocin yield and application. This class of antimicrobial peptides has the potential to replace chemical food preservatives in the future.
Substances of Milky Juice of Genus Lactarius Fungi: Chemical and Toxicological
Characteristics
Authors: Antonyuk Volodymyr O. , Panchak Lydia V. , Tsivinska Mariana V. , Stoika Rostyslav S. 
Published: August 2022

Background:
Fungi of the genus Lactarius Pers. before the maturation of spores are not
damaged by microorganisms, insects, mollusks, and animals. Such resistance correlates with the period
when the basidiomes of these fungi are filled with milky juice, which contains substances of various
chemical nature that provide their protection.

Objective:
The aim of our work is to present the results of our recent and previously published studies
on the identification and toxicological characteristics of substances available in the milky juice of fungi
of the genus Lactarius Pers and used for protection against predator and parasite organisms. The possibility of using these substances to suppress tumor cells is also discussed.

Methods:
The biological effect of the juice of L. pergamenus, L. quietus, and L. volemus, as well as
methylene chloride, extracts obtained from fresh, frozen and dried basidiomes of L. pergamenus was
studied. Purification of individual fractions of hexane extract from the basidiomes was performed by
chromatography on a silica gel column and their analysis by done by thin layer chromatography and
gas chromatography mass spectrometry.

Results:
The sesquiterpene aldehydes were shown to be the main component of the chemical protection system of Lactarius. These agents are present in the milky juice of the Lactarius fungi, and they
are easily oxidized by oxygen in the air. The milky juice of these mushrooms is also rich in higher fatty
acids and phthalates. Phthalates possess an insecticidal effect, while higher fatty acids are capable of
forming adducts with sesquiterpenes that provide emulsion stability. Water-soluble substances, in particular, the polyphenol oxidase enzyme, whose activity correlates with the content of milky juice in
basidiomes, also play a protective role.

Conclusion:
Milky juice of mushrooms of Lactarius Pers. genus is a stable balanced emulsion containing a large number of substances. One part is responsible for the toxic effects on other organisms,
while the other part determines the chemical stability of the emulsion. Altogether, they create an effective system of protection of fungi of the Lactarius genus against microorganisms, insects, mollusks,
and animals.
Application of Fuzzy Neutrosophic Cone in Decision Making
Authors: Kumar De Sujit , Bhattacharya Kousik , Roy Biswajit 
Published: August 2022

Aims:
This article deals with a new decision-making process under a neutrosophic fuzzy
environment. First of all, we develop various types of neutrosophic set by means of neutrosophic
cones. In fact, this set has been developed from the general equation of second degree in the field
of classical geometry. Considering the neutrosophic components “true membership”, the “falsity
membership” and the “indeterminacy” as the three variables of three-dimensional rectangular axes
we develop various types of cones like structures of the traditional neutrosophic set and hence a
new defuzzification method.

Background:
Fuzzy set has some limitations in its domain [0,1] to describe real-life decisionmaking
problems. The problem of difficulties lies in the variation of lower and upper bound and
also the single valued logic (membership function only) systems. In reality, three valued logics
(membership function, non-membership function and indeterminacy) have been established in the
name of Neutrosophic logic/sets, and two valued logics (membership and non-membership functions)
have developed in the name of Intuitionistic fuzzy logic/sets. In three valued logic system,
the concepts of negation are now a growing subject of any group decision making problems. However,
to draw a clear estimation of a neutrosophic decision has not yet been studied by modern researchers.

Objective:
Various kinds of new establishments of the Neutrosophic set have been studied from the
algebraic point of view, along with some polynomial structures. We have seen that; no finite geometric
structures have been developed yet to qualify the real-world problems.

Method:
We consider the three components of a neutrosophic set as the variables of threedimensional
geometry. Since, the decisions are compact and constructive, we may consider the
convex neutrosophic cone for analyzing single/ multiple group decision making problems.

Result:
Various definitions are made over the cone- fundamentals using non-standard neutrosophic
set in the domain [−1,1] × [−1,1] × [−1,1]. Then, we studied the constructions of several expressions/
functions of neutrosophic cones, such as reciprocal cone, and enveloping cone via a novel
thinking process. Then using some examples, we have developed a new ranking method along
with their geometric structures exclusively.

Conclusion:
In this changing world, the nature of decision-making behaviors is also changing rapidly.
So, the need of establishing new concepts is an emerging area of research. However, more attention
is required in discussing such vital issues in near future. The proposed approach may be applied
to the decision-making problems of global issues also.
Perceived Unmet Needs in Patients Living With Advanced Bladder Cancer and Their Caregivers: Infodemiology Study Using Data From Social Media in the United States
Authors: Renner Simon , Loussikian Paul , Foulquié Pierre , Arnould Benoit , Marrel Alexia , Barbier Valentin , Mebarki Adel , Schück Stéphane , Bharmal Murtuza 
Published: August 2022

Background
Locally advanced or metastatic bladder cancer (BC), which is generally termed advanced BC (aBC), has a very poor prognosis, and in addition to its physical symptoms, it is associated with emotional and social challenges. However, few studies have assessed the unmet needs and burden of aBC from patient and caregiver perspectives. Infodemiology, that is, epidemiology based on internet health-related content, can help obtain more insights on patients’ and caregivers’ experiences with aBC.

Objective
The study aimed to identify the main discussion themes and the unmet needs of patients with aBC and their caregivers through a mixed methods analysis of social media posts.

Methods
Social media posts were collected between January 2015 and April 2021 from US geolocalized sites using specific keywords for aBC. Automatic natural language processing (regular expressions and machine learning) methods were used to filter out irrelevant content and identify verbatim posts from patients and caregivers. The verbatim posts were analyzed to identify main discussion themes using biterm topic modeling. Difficulties or unmet needs were further explored using qualitative research methods by 2 independent annotators until saturation of concepts.

Results
A total of 688 posts from 262 patients and 1214 posts from 679 caregivers discussing aBC were identified. Analysis of 340 randomly selected patient posts and 423 randomly selected caregiver posts uncovered 33 unique unmet need categories among patients and 36 among caregivers. The main unmet patient needs were related to challenges regarding adverse events (AEs; 28/95, 29%) and the psychological impact of aBC (20/95, 21%). Other patient unmet needs identified were prognosis or diagnosis errors (9/95, 9%) and the need for better management of aBC symptoms (9/95, 9%). The main unmet caregiver needs were related to the psychological impacts of aBC (46/177, 26.0%), the need for support groups and to share experiences between peers (28/177, 15.8%), and the fear and management of patient AEs (22/177, 12.4%).

Conclusions
The combination of manual and automatic methods allowed the extraction and analysis of several hundreds of social media posts from patients with aBC and their caregivers. The results highlighted the emotional burden of cancer for both patients and caregivers. Additional studies on patients with aBC and their caregivers are required to quantitatively explore the impact of this disease on quality of life.
Health Information Sourcing and Health Knowledge Quality: Repeated Cross-sectional Survey
Authors: Korshakova Elena , Marsh Jessecae K , Kleinberg Samantha 
Published: August 2022

Background
People’s health-related knowledge influences health outcomes, as this knowledge may influence whether individuals follow advice from their doctors or public health agencies. Yet, little attention has been paid to where people obtain health information and how these information sources relate to the quality of knowledge.

Objective
We aim to discover what information sources people use to learn about health conditions, how these sources relate to the quality of their health knowledge, and how both the number of information sources and health knowledge change over time.

Methods
We surveyed 200 different individuals at 12 time points from March through September 2020. At each time point, we elicited participants’ knowledge about causes, risk factors, and preventative interventions for 8 viral (Ebola, common cold, COVID-19, Zika) and nonviral (food allergies, amyotrophic lateral sclerosis [ALS], strep throat, stroke) illnesses. Participants were further asked how they learned about each illness and to rate how much they trust various sources of health information.

Results
We found that participants used different information sources to obtain health information about common illnesses (food allergies, strep throat, stroke) compared to emerging illnesses (Ebola, common cold, COVID-19, Zika). Participants relied mainly on news media, government agencies, and social media for information about emerging illnesses, while learning about common illnesses from family, friends, and medical professionals. Participants relied on social media for information about COVID-19, with their knowledge accuracy of COVID-19 declining over the course of the pandemic. The number of information sources participants used was positively correlated with health knowledge quality, though there was no relationship with the specific source types consulted.

Conclusions
Building on prior work on health information seeking and factors affecting health knowledge, we now find that people systematically consult different types of information sources by illness type and that the number of information sources people use affects the quality of individuals’ health knowledge. Interventions to disseminate health information may need to be targeted to where individuals are likely to seek out information, and these information sources differ systematically by illness type.
Sundhed.dk and MyHealth During the Corona Storm
Authors: Elbæk Petersen Morten 
Published: August 2022

Background
The Danish eHealth portal, sundhed.dk, pioneers open access to medical records since 2003 and is, in this regard, unique worldwide. As part of the Danish health care sector, sundhed.dk supports transparency and patient empowerment and provides health professionals with the possibility to access patient health data outside of local systems and across sectors and boundaries. Sundhed.dk and the MyHealth app have played a crucial role during the COVID-19 pandemic in Denmark, not least due to the development of the corona passport.

Objective
The overall purpose during the COVID-19 pandemic has been to assist the health authorities handling the pandemic and to support patient empowerment. Sundhed.dk provided new digital services to support monitoring the spread of the virus and telemedicine solutions to support the Danish citizens both during isolation and as the society was gradually reopening.

Methods
By exploiting sundhed.dk’s known and widespread position in the society and the already existing digital building blocks, sundhed.dk and MyHealth managed to provide fast and easy access to COVID-19 laboratory responses and, on top of that, to develop the corona passport, which was the result of accelerated IT development and fast scaling of the required server with the users.

Results
The many digital services accessible through sundhed.dk or MyHealth made it possible for Danish citizens to continue to see their doctor or physiotherapist during lockdown. Moreover, the corona passport made the safe and efficient reopening of Denmark possible.

Conclusions
The story of sundhed.dk during the COVID-19 pandemic is a story of success, a result of its close interdisciplinary and cross-sectoral cooperation with Danish health authorities and private IT vendors. It illustrates what can be achieved when there is a unified blueprint and overall purpose to overcome barriers in order to ensure development and progress for both the individual and the society. This has also drawn global attention, as reflected in a report by the World Health Organization.
Sandino, Guiteras y las variantes del nacionalismo revolucionario
Authors: Rojas Rafael 
Published: August 2022

el objetivo de este artículo es analizar los movimientos políticos encabezados por el nicaragüense César Augusto Sandino y el cubano Antonio Guiteras en sus respectivos países, pero en el contexto del nacionalismo revolucionario y de la lucha antimperialista de la región en la tercera década del siglo xx. Basado en un análisis comparativo y sustentado con fuentes primarias y secundarias, el artículo revela y demuestra las variantes del nacionalismo revolucionario expresado a partir de las condiciones políticas e ideológicas específicas de Nicaragua y Cuba de esos años, destacando, como principal hallazgo, la identificación y descripción de nombres, grupos, ideas, y organizaciones políticas en el proceso histórico que caracterizó a cada nación.Palabras clave: Sandino; Guiteras; Nacionalismo revolucionario; Socialismo; Antimperialismo; América Latina.
Nivolumab Versus Cetuximab In Recurrent/Metastatic Squamous Cell Carcinoma Of The Head And Neck. A Real-World Data Study
Authors: Rivas Lola Macía , Carbajales-Álvarez Mónica , Fernández-Laguna Clara , Álvarez-Asteinza Cristina , Maray-Mateos Iván , Lozano-Blázquez Ana 
Published: August 2022

Aim
Assess the effectiveness and safety of nivolumab versus cetuximab in
patients with R/M HNSCC, as well as to analyze possible prognostic
factors for response to treatment with nivolumab.
Methods
We conducted an observational, retrospective, descriptive study of
patients with R/M HNSCC who initiated treatment with nivolumab or
cetuximab monotherapy in two periods of equivalent duration. Overall
efficacy was measured in progression-free survival (PFS) and overall
survival (OS); safety was evaluated using the CTCAE (Common Terminology
Criteria for Adverse Events) classification version 5.0 of the National
Cancer Institute (NCI).
Results
Median overall survival (OS) was 9.1 months with nivolumab (n=34) vs.
6.3 months with cetuximab (n=12)(HR=0.5; 95%CI: 0.24-1.03; p=0.058).
Progression free survival (PFS) were 4.3 for nivolumab and 4.65 months
for cetuximab (HR=0.59; 95%CI: 0.29-1.19; p=0.14). Any grade adverse
events (AEs) were reported in 97% and 100% of the patients treated
with nivolumab and cetuximab. Serious AEs were observed in 26% and 58%
of the patients respectively. Elevated albumin values, lymphocytosis,
neutropenia and elevated neutrophil/lymphocyte ratio values have
positive prognostic value on the response to nivolumab in R/M CCECC.
Conclusion
Effectiveness of nivolumab in terms of OS remains superior to cetuximab.
OS, PFS and severe or any grade AEs were superior in both arms of our
study than in the clinical trials. The AEs profile of nivolumab differs
in our study from the clinical trials’ observations. We have identified
four positive statistically significant prognostic variables on the
response to nivolumab in R/M HNSCC.