bluuebunny/crossref_metadata_2025_split huggingface dataset:
Боротьба за скликання Помісного собору Автокефальної Православної Церкви у Польщі в другій половині 20-х – 30-х роках ХХ століття
Authors: Нерода Інна 
Published: October 2022

Метою статті є дослідження особливостей процесу боротьби за скликання Помісного собору Автокефальної Православної Церкви в Польщі (АПЦП) у другій половині 20-х – 30-х роках ХХ століття, метою якого було врегулювання її правового статусу і майнового положення. Авторкою проаналізовано архівні документи, матеріали тогочасної періодичної преси та видань, в яких висвітлювалися проблеми щодо скликання Помісного собору АПЦП. Методологія дослідження. Методологічну основу статті склали принципи історизму, об’єктивності, системності, міждисциплінарного підходу. Застосовано загальнонаукові, спеціально-історичні та міждисциплінарні методи. Кожен із них у конкретній ситуації був результативним і дозволив об’єктивно реконструювати процеси щодо скликання Помісного собору Автокефальної Православної Церкви у Польщі. Наукова новизна роботи полягає у тому, що авторка на основі архівних документів та матеріалів періодичної преси досліджуваного періоду з’ясувала особливості процесу боротьби за скликання Помісного собору АПЦП. Дослідження ґрунтується на новому джерельному матеріалі, який вперше вводиться до наукового вжитку. На відміну від попередніх робіт, присвячених цій темі, у статті більш рельєфно виявлена динаміка змін у релігійній політиці як Польської держави, так і Римо-католицького костелу щодо Православної церкви. Висновки. Після проголошення автокефалії Православна церква у Польщі потребувала врегулювання свого правового статусу та внутрішньої реорганізації. Вирішення цих питань було дуже важливим для забезпечення церковно-релігійних потреб православної громади. Перед православ’ям стояла ціла низка проблем. Їх вирішення залежало від польського уряду, православної ієрархії і вірян. Переплетення інтересів цих трьох основних чинників спрямовувало процес організаційного та правового становлення АПЦП. Наприкінці 20-х і 30-х роках ХХ ст. на захист інтересів АПЦП активно стали українські посли і сенатори. Вони домагалися задоволення потреб українського православного населення з трибун сейму і сенату, перед церковною та світською владою. Створене у 1931 році Волинське українське об’єднання (ВУО) та Товариство імені митрополита Петра Могили домагалися скликання Помісного собору АПЦП, який мав врегулювати її правовий статус і майнове становище. Однак на шляху скликання Собору зустрічалися перепони з боку православної ієрархії та польського уряду. Він так і не відбувся. Але постійні передсоборні приготування стали імпульсом до активізації православних вірян, які відстоювали права своєї Церкви.
Prevalence of anemia and its risk factors among supplemented and non-supplemented pregnant women in Sulaimani city Kurdistan-Iraq
Authors: Qadir Pirot Aras , M. Weli Sardar 
Published: October 2022

Abstract:
Background: Anaemia is a serious global public health problem that particularly affects pregnant women. It was estimated that 41.8% of pregnant women worldwide were anaemic.
Objectives: The objectives of this study were to find out the prevalence of anemia and its associated risk factors among supplemented and non-supplemented pregnant women in Sulaimani city.
Patient and methods: Sixty hundred and forty one samples were collected randomly from the pregnant and control women. Data concerned to age, education, residence, and obstetrical related factors were collected by face to face interview. Finally, 5 ml of venous blood were collected from each pregnant woman for complete blood count, serum iron, serum ferritin, folic acid and vitamin B12 determination.
Results: this study found that 74.2% and 34.9 of non-supplemented and supplemented pregnant women were anemic respectively. Factors such as; gestational age, gravidity, history of abortion, birth intervals, age, occupation, level of education, body mass index, family income and blood pressure were significantly associated with the rate of anaemia. There were differences between the rate of anemia among supplemented and non-supplemented pregnant women in all factors, the rates were decreased in the supplemented groups. The normal percentage of serum ferritin was very low; 16.5% and 38.4% among non-supplemented and supplemented anemic pregnant women respectively.
Conclusion: the prevalence of anemia was high among non-supplemented compared to supplemented pregnant women. The majority of anemia was mild type. All risk factors that are associated with anemia were decreased in supplemented compared to non-supplemented pregnant women. Most of the anemic cases in our result are iron deficient.
Experimental design and numerical investigation of a photoacoustic sensor for a low-power, continuous-wave, laser-based frequency-domain photoacoustic microscopy
Authors: Sathiyamoorthy Krishnan , Kolios Michael 
Published: October 2022

<p>We have developed a photoacoustic (PA) sensor using a low-power, continuous- wave laser and a kHz-range microphone. The sensor is simple, flexible, cost-effective, and compatible with commercial optical microscopes. The sensor enables noncontact PA measurements through air, whereas most current existing PA techniques require an acoustic coupling liquid for detection. The PA sensor has three main components: one is the chamber that holds the sample, the second is a resonator column used to amplify the weak PA signals generated within the sample chamber, and the third is a microphone at the end of the resonator column to detect the amplified signals. The chamber size was designed to be 8  mm  ×  3  mm as the thermal diffusion length and viscous-thermal damping of air at room pressure and temperature are 2 and 1 mm, respectively. We numerically and experimentally examined the effect of the resonator column size on the frequency response of the PA sensor. The quality factor decreased significantly when the sample chamber size was reduced from 4  mm  ×  3  mm to 2  mm  ×  3  mm due to thermos-viscous damping of the air. The quality factor decreased by 27%, demonstrating the need for optimal design for the sample chamber and resonator column size. The system exhibited noise equivalent molecular sensitivity (NEM) per unit bandwidth (NEM  /    √  Δ<em>f</em>) of ∼19,966  Hz  −  1/2 or 33  ×  10  −  21  mol or 33 zeptomol, which is an improvement of 2.2 times compared to the previous system design. This PA sensor has the potential for noncontact high-resolution PA imaging of materials without the need for coupling fluids. </p>
Sex-specific differences in sleep-disordered breathing and nocturnal hypoxemia in chronic thromboembolic pulmonary hypertension and chronic thromboembolic pulmonary disease
Authors: Li Hui-Ting , Yuan Ping , Zhao Qin-Hua , Gong Su-Gang , Jiang Rong , Li Jin-Ling , Liu Hong-Ting , Qiu Hong-Ling , Wu Wen-Hui , Luo Ci-Jun , He Jing , Wang Lan , Liu Jin-Ming 
Published: October 2022

ObjectiveAlthough chronic thromboembolic pulmonary hypertension (CTEPH) and chronic thromboembolic pulmonary disease (CTEPD) are known to be accompanied by symptoms associated with sleep-disordered breathing (SDB) and nocturnal hypoxemia, the sex-specific differences of SDB and nocturnal hypoxemia in patients with CTEPH and CTEPD remain unknown.MethodsBetween July 2020 and August 2022, data were retrieved from 57 males and 63 female patients with CTEPH and CTEPD who underwent sleep study at Shanghai Pulmonary Hospital. Nocturnal mean SpO2 (mean SpO2) &lt; 90% was defined as nocturnal hypoxemia. Logistic and linear regression analysis was performed to assess the predictive value of sleep study indices to hemodynamic parameters. Receiver operating characteristic (ROC) curve was applied to analyze the specific parameters to predict the risk of CTEPH.ResultsSDB was similarly present in males and females, and both sexes predominantly had obstructive sleep apnea (OSA); more women were diagnosed with nocturnal hypoxemia (32 vs. 7%, p = 0.002). SaO2 was negatively associated with mean pulmonary arterial pressure (mPAP) in men (p &lt; 0.001), whereas the ratio of nocturnal SpO2 &lt; 90% of the total monitoring time (T90%) was positively correlated with mPAP. Mean SpO2 was an independent predictor for pulmonary vascular resistance and cardiac output in women (p = 0.001, p &lt; 0.001, p = 0.001, respectively). T90%, SaO2, and minimal SpO2 were combined to develop a new composite parameter: hypoxemia scoring index (HSI). ROC curve analysis indicated that HSI levels of 0.55 could discriminate CTEPH from CTEPD with a sensitivity of 92.3% and specificity of 87.5% in female patients (an area under the curve, 0.937; 95% CI: 0.879–0.995, p &lt; 0.001).ConclusionSex-specific nocturnal hypoxemia was present in patients with CTEPH or CTEPD. In female patients, the HSI showed high capacity for predicting the risk of CTEPH.Clinical trials registrationRegistry: chictr.org.cn; Identifier: ChiCTR-DDD-16009406.
Using the changes of several simple anthropometric indices to predict the occurrence of metabolic syndrome: Findings from medically under-resourced communities in rural China
Authors: Li Qiyu , Wang Pengbo , Li Guangxiao , Chang Ye , Guo Xiaofan , Sun Yingxian , Zhang Xingang 
Published: October 2022

BackgroundVarious anthropometric indices have been proved to be useful to predict metabolic syndrome(MetS), but the association between changes in anthropometric indices and the onset of MetS is unclear. This study selected six indices that are easy to measure and calculate in daily life and evaluated the relationships.MethodsWe established a prospective cohort in rural China during 2012-2013 and involved 5,221 participants without MetS. The follow-up visit was conducted in 2015 to repeat anthropometric indices measurements and assess MetS onset. Binary logistic regression model was used to calculate the association between changes in anthropometric indices and MetS onset. Receiver operating characteristic (ROC) curve was drawn to compare their abilities in MetS prediction.ResultsOver a median follow-up time of 2.42 years, 1,367 participants (26.2%) developed MetS. The increase in all the six indices is associated with an increased risk of MetS. Changes in WC and WHtR are the strongest predictors, with a 5 cm increase in WC and a 0.025 increase in WHtR giving the best prediction of MetS onset.ConclusionsPeople should be aware of changes in these six anthropometric indices in daily life, as their increase is closely related to an increased risk of MetS, especially WC and WHtR. We recommend an increase of 5 cm in WC and 0.025 in WHtR as the optimal cut-off for the MetS prediction.
Effects of microvibration stimulation on developmental potential of discarded germinal vesicle oocytes of human
Authors: Liu Qinli , Zhao Sen , Zhou Jian , Liu Ping , Huo Bo 
Published: October 2022

ObjectiveThis research aims to study the effects of continuous microvibration stimulation on the parthenogenetic development of human germinal vesicle oocytes.MethodsNinety-five discarded germinal vesicle oocytes from intracytoplasmic sperm injection treatment (ICSI) cycles performed at Amcare Women’s &amp; Children’s Hospital between January and December 2021 were used for conventional static culture as well as 10 Hz microvibration culture. We investigated the differences between the two groups in terms of oocyte maturation rate, parthenogenetic activation rate, and parthenogenetic blastocyst formation rate.ResultsThe static culture and 10 Hz microvibration culture of 95 oocytes showed that the parthenogenetic blastocyst formation rate in the microvibration culture group was significantly higher than those in the traditional static culture group.ConclusionA continuous microvibration stimulation can significantly improve the parthenogenetic developmental potential of human immature oocytes.
Significance of radiofrequency ablation in large solid benign thyroid nodules
Authors: Lin Yan , Shi Yao-ping , Tang Xiao-yin , Ding Min , He Yi , Li Ping , Zhai Bo 
Published: October 2022

ObjectiveThe aim of this study is to explore efficacy and safety for radiofrequency ablation (RFA) among cases attacked by large benign solid thyroid nodules, mainly focusing on volume reduction, complication rate, and thyroid function.Methods and materialsFrom June 2015 to November 2019, 24 patients with 25 large benign solid thyroid nodules (more than 25 ml) underwent single or sequential RFA in our institution. Eleven nodules achieved complete ablation after single RFA, whereas the other 14 nodules received sequential RFA. Volume reduction in large nodules was evaluated. Following single or sequential RFA, all patients received clinical and ultrasound evaluations, and the median follow-up duration among them was 23.5 months. Technical success, complication rate, and recurrence rate were assessed as well.ResultsIn single RFA group, volume reduction ranged from 62.6% to 99.4% (mean ± SD, 93.6 ± 9.9%) 6 months after RFA. In sequential RFA group, volume reduction ranged from 30.6% to 92.9% (mean ± SD, 67.4 ± 17.8%) after the first RFA and was between 83.4% and 98.4% (mean ± SD, 94.8± 3.8%) 6 months after the second RFA. The concentrations of FT3 and FT4 increased slightly 1 day after RFA and returned to normal level 1 month after.ConclusionsSingle or sequential RFA is safe and effective in treating large benign solid thyroid nodules (more than 25 ml) that cause obvious compressive symptoms. Hence, compression symptoms and cosmetic conditions could be effectively improved through single or sequential RFA without marginal recurrence.
Case report: A rare case of coexisting Waldenstrom Macroglobulinemia and B-cell acute lymphoblastic leukemia with KMT2D and MECOM mutations
Authors: Wang Lingling , Tang Jiao , Feng Jun , Huang Yongfen , Cheng Yuexin , Xu Hao , Miao Yuqing 
Published: October 2022

BackgroundWaldenstrom Macroglobulinemia (WM) is a rare and indolent lymphoma of B-cell origin characterized by elevated monoclonal IgM, with MYD88L265P mutation and CXCR4 mutation as common molecular alterations. B-cell Acute Lymphoblastic Leukemia (B-ALL) is clinically heterogeneous, characterized by abnormal proliferation and aggregation of immature lymphocytes in the bone marrow and lymphoid tissue. WM and ALL are hematologic malignancies of B-cell origin with completely different clinical manifestations and biological features. KMT2D and MECOM mutations are very rare in ALL and usually indicate poor disease prognosis. The coexistence of WM and ALL with KMT2D and MECOM mutations have not been reported.Case presentationA 74-year-old female patient was diagnosed with WM in July 2018 and received four cycles of chemotherapy of bortezomib and dexamethasone. In November 2018, she received immunomodulator thalidomide as maintenance therapy. In November 2020, Bruton’s Tyrosine Kinase inhibitors (BTKi) has been introduced into the Chinese market and she took zanubrutinib orally at a dose of 80 mg per day. The disease remained in remission. In December 2021, she presented with multiple enlarged lymph nodes throughout the body. Bone marrow and next-generation sequencing (NGS) suggested the coexistence of WM and B-ALL with KMT2D and MECOM mutations. The patient was treated with zanubrutinib in combination with vincristine and dexamethasone, after which she developed severe myelosuppression and septicemia. The patient finally got remission. Due to the patient’s age and poor status, she refused intravenous chemotherapy and is currently treated with zanubrutinib.ConclusionsThe coexistence of WM and B-ALL is very rare and has not been reported. The presence of both KMT2D and MECOM mutations predicts a poor prognosis and the possibility of insensitivity to conventional treatment options. BTKi achieves its anti-tumor effects by inhibiting BTK activation and blocking a series of malignant transformations in B-cell tumors. In addition, it also acts on T-cell immunity and tumor microenvironment. Combination therapy based on BTKi may improve the prognosis of this patient.
Microbial dysbiosis and lack of SCFA production in a Spanish cohort of patients with multiple sclerosis
Authors: Moles Laura , Delgado Susana , Gorostidi-Aicua Miriam , Sepúlveda Lucía , Alberro Ainhoa , Iparraguirre Leire , Suárez Jose Alberto , Romarate Leire , Arruti Maialen , Muñoz-Culla Maider , Castillo-Triviño Tamara , Otaegui David ,   The international Multiple Sclerosis Microbiome Study Consortium
Published: October 2022

BackgroundMultiple sclerosis (MS) is a chronic, demyelinating, and immune-mediated disease of the central nervous system caused by a combination of genetic, epigenetic, and environmental factors. The incidence of MS has increased in the past several decades, suggesting changes in the environmental risk factors. Much effort has been made in the description of the gut microbiota in MS; however, little is known about the dysbiosis on its function. The microbiota produces thousands of biologically active substances among which are notable the short-chain fatty acid (SCFA) excretion.ObjectivesAnalyze the interaction between microbiota, SCFAs, diet, and MS.Methods16S, nutritional questionnaires, and SCFAS quantification have been recovered from MS patients and controls.ResultsOur results revealed an increment in the phylum Proteobacteria, especially the family Enterobacteriaceae, a lack in total SCFA excretion, and an altered profile of SCFAs in a Spanish cohort of MS patients. These alterations are more evident in patients with higher disability.ConclusionsThe abundance of Proteobacteria and acetate and the low excretion of total SCFAs, especially butyrate, are common characteristics of MS patients, and besides, both are associated with a worse prognosis of the disease.
miRNA profile at diagnosis predicts treatment outcome in patients with B-chronic lymphocytic leukemia: A FILO study
Authors: Duroux-Richard Isabelle , Gagez Anne-Laure , Alaterre Elina , Letestu Rémi , Khalifa Olfa , Jorgensen Christian , Leprêtre Stéphane , Tchernonog Emmanuelle , Moreaux Jérôme , Cartron Guillaume , Apparailly Florence 
Published: October 2022

During many years, chemo-immunotherapy fludarabine-cyclophosphamide-rituximab (FCR) was the gold standard for first line treatment of medically fit patients with symptomatic B-chronic lymphocytic leukemia (CLL). Over the last decade, targeted biotherapies have revolutionized the treatment of B-CLL patients and almost entirely supplanted FCR. However, no biomarker still exists to predict the complete remission (CR) with undetectable minimal residual disease (uMRD) in bone marrow (BM), which remains the best predictive factor for survival. MicroRNAs represent a class of molecular biomarkers which expression is altered in B-CLL. Our study aimed at identifying before treatment blood miRNAs that predict treatment outcome in previously untreated B-CLL patients (NCT 01370772, https://clinicaltrials.gov/ct2/show/NCT01370772). Using hierarchical clustering of miRNA expression profiles discriminating 8 patients who achieved CR with BM uMRD from 8 patients who did not achieve CR and displayed detectable BM MRD, we identified 25 miRNAs differentially expressed before treatment. The expression of 11 miRNAs was further validated on a larger cohort (n=123). Based on the dosage of 5 miRNAs at diagnosis, a decision tree was constructed to predict treatment outcome. We identified 6 groups of patients with a distinct probability of being CR with BM uMRD to FCR treatment, ranging from 72% (miR-125b, miR-15b and miR-181c high) to 4% (miR-125b and miR-193b low). None of the patients displaying high expression levels of miR-125b, miR-15b and miR-181c relapsed during study follow-up. In contrast, patients with low miR-15b and high miR-412, or with low miR-125b and miR-193b, demonstrated significant low PFS. RNA sequencing of blood at diagnosis identified that patients relapsing after treatment are characterized by significant enrichment of gene signatures related to cell cycle, MYC target genes, metabolism and translation regulation. Conversely, patients achieving CR with BM uMRD displayed significant enrichment in genes related to communication between CLL cells and the microenvironment, immune system activation and upregulation of polycomb PRC2 complex target genes. Our results suggest that blood miRNAs are potent predictive biomarkers for FCR treatment efficacy and might be implicated in the FCR efficacy in B-CLL patients, providing new insight into unmet need for the treatment of B-CLL patients and identifying pathways predictive of patients’ remission.Clinical trial registrationClinicalTrials.gov, identifier NCT 01370772.
Salvage high intensity focused ultrasound for residual or recurrent cervical cancer after definitive chemoradiotherapy
Authors: Zhong Qin , Tang Fei , Ni Tingting , Chen Yanping , Liu Yuncong , Wu Jing , Zhou Wen , Feng Zhiyu , Lu Xiaokai , Tan Shisheng , Zhang Yu 
Published: October 2022

ObjectiveThe treatment of residual/recurrent cervical cancer within a previously irradiated area is challenging and generally associated with a poor outcome. Local treatments such as salvage surgery and re-irradiation are usually traumatic and have limited efficacy. High intensity focused ultrasound (HIFU) treatment can directly ablate solid tumors without damaging neighboring healthy tissue. However, the HIFU studies for these patients are limited. Experience gained over the course of 10 years with the use of HIFU for the management of residual/recurrent cervical cancer after chemoradiotherapy is reported herein.Methods153 patients with residual/recurrent cervical cancer in a previously irradiated field who received HIFU treatment between 2010 and 2021 were retrospectively analyzed. Adverse effects, survival benefit and factors affecting prognosis were given particular attention.ResultsA total of 36 patients (23.5%) achieved a partial response following HIFU treatment and 107 patients (69.9%) had stable disease. The objective response and disease control rates were 23.5% and 93.5%, respectively. The median progression-free survival (mPFS) and median overall survival (mOS) were 17.0 months and 24.5 months, respectively. Moreover, patients with lesions ≥1.40 cm before HIFU treatment and a shrinkage rate ≥ 30% after treatment had a higher mPFS and mOS, and patients with lesions ≤1.00 cm after HIFU treatment had a higher mPFS (P=&lt;0.05). All the treatment-related adverse events were limited to minor complications, which included skin burns, abdominal pain and vaginal discharge.ConclusionsHIFU treatment is likely a preferred option for cervical cancer patients with residual disease or recurrence following CRT that can safely improve the local control rate and extend survival.