bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reorganization of prefrontal network in stroke patients with dyskinesias: evidence from resting‐state functional near‐infrared spectroscopy
Authors: Pang Richong , Wang Dan , Chen Tara Scarlette Rosalyn , Yang Anping , Yi Li , Chen Sisi , Wang Jie , Wu Kai , Zhao Chaochao , Liu Hua , Ai Yilong , Yang Aoran , Sun Jinyan 
Published: March 2022

AbstractStroke usually causes multiple functional disability. To develop novel rehabilitation strategies, it is quite necessary to improve the understanding of post‐stroke brain plasticity. Here, we use functional near‐infrared spectroscopy to investigate the prefrontal cortex (PFC) network reorganization in stroke patients with dyskinesias. The PFC hemodynamic signals in the resting state from 16 stroke patients and 10 healthy subjects are collected and analyzed with the graph theory. The PFC networks for both groups show small‐world attributes. The stroke patients have larger clustering coefficient and transitivity and smaller global efficiency and small‐worldness than healthy subjects. Based on the selected network features, the established support vector machine model classifies the two groups of subjects with an accuracy rate of 88.5%. Besides, the clustering coefficient and local efficiency negatively correlate with patients' motor function. This study suggests that the PFC of stroke patients with dyskinesias undergoes specific network reorganization.
Comparative evaluation of mesenchymal stromal cell growth and osteogenic differentiation on a shape memory polymer scaffold
Authors: Stukel Shah Jessica M. , Lundquist Bridney , Macaitis Joseph , Pfau‐Cloud Michaela R. , Beltran Felipe O. , Grunlan Melissa A. , Lien Wen , Wang Heuy‐Ching , Burdette Alexander J. 
Published: March 2022

AbstractTrauma‐induced, critical‐size bone defects pose a clinical challenge to heal. Albeit autografts are the standard‐of‐care, they are limited by their inability to be shaped to various defect geometries and often incur donor site complications. Herein, the combination of a “self‐fitting” shape memory polymer (SMP) scaffold and seeded mesenchymal stromal cells (MSCs) was investigated as an alternative. The porous SMP scaffold, prepared from poly(ε‐caprolactone) diacrylate (PCL‐DA) and coated with polydopamine, provided conformal shaping and cell adhesion. MSCs from five tissues, amniotic (AMSCs), chorionic tissue (CHSCs), umbilical cord (UCSCs), adipose (ADSCs), and bone marrow (BMSCs) were evaluated for viability, density, and osteogenic differentiation on the SMP scaffold. BMSCs exhibited the fastest increase in cell density by day 3, but after day 10, CHSCs, UCSCs, and ADSCs approached similar cell density. BMSCs also showed the greatest calcification among the cell types, followed closely by ADSCs, CHSCs and AMSCs. Alkaline phosphatase (ALP) activity peaked at day 7 for AMSCs, UCSCs, ADSCs and BMSCs, and at day 14 for CHSCs, which had the greatest overall ALP activity. Of all the cell types, only scaffolds cultured with ADSCs in osteogenic media had increased hardness and local modulus as compared to blank scaffolds after 21 days of cell culture and osteogenic differentiation. Overall, ADSCs performed most favorably on the SMP scaffold. The SMP scaffold was able to support key cellular behaviors of MSCs and could potentially be a viable, regenerative alternative to autograft.
Towards improved FAIRness of the ThermoML Archive
Authors: Riccardi Demian , Trautt Zachary , Bazyleva Ala , Paulechka Eugene , Diky Vladimir , Magee Joseph W. , Kazakov Andrei F. , Townsend Scott A. , Muzny Chris D. 
Published: March 2022

AbstractThe ThermoML Archive is a subset of Thermodynamics Research Center (TRC) data holdings corresponding to cooperation between NIST TRC and five journals: Journal of Chemical Engineering and Data (ISSN: 1520‐5134), The Journal of Chemical Thermodynamics (ISSN: 1096‐3626), Fluid Phase Equilibria (ISSN: 0378‐3812), Thermochimica Acta (ISSN: 0040‐6031), and International Journal of Thermophysics (ISSN: 1572‐9567). Data from initial cooperation (around 2003) through the 2019 calendar year are included. The archive has undergone a major update with the goal of improving the FAIRness and user experience of the data provided by the service. The web application provides comprehensive property browsing and searching capabilities; searching relies on a RESTful API provided by the Cordra software for managing digital objects. JSON files with a schema derived from ThermoML are provided as an additional serialization to lower the barrier to programmatic consumption of the information, for stakeholders who may have a preference of JSON over XML. The ThermoML and JSON files for all available entries can be downloaded from data.nist.gov (https://data.nist.gov/od/id/mds2-2422).
Conformations and binding pockets of HRas and its guanine nucleotide exchange factors complexes in the guanosine triphosphate exchange process
Authors: Xiong Yuqing , Zeng Juan , Xia Fei , Cui Qiang , Deng Xianming , Xu Xin 
Published: March 2022

AbstractThe human Son of Sevenless (SOS) activates the signal‐transduction protein Ras by forming the complex SOS·Ras and accelerating the guanosine triphosphate (GTP) exchange in Ras. Inhibition of SOS·Ras could regulate the function of Ras in cells and has emerged as an effective strategy for battling Ras related cancers. A key factor to the success of this approach is to understand the conformational change of Ras during the GTP exchange process. In this study, we perform an extensive molecular dynamics simulation to characterize the specific conformations of Ras without and with guanine nucleotide exchange factors (GEFs) of SOS, especially for the substates of State 1 of HRasGTP∙Mg2+. The potent binding pockets on the surfaces of the RasGDP∙Mg2+, the S1.1 and S1.2 substates in State 1 of RasGTP∙Mg2+ and the ternary complexes with SOS are predicted, including the binding sites of other domains of SOS. These findings help to obtain a more thorough understanding of Ras functions in the GTP cycling process and provide a structural foundation for future drug design.
On a relation between bipartite biregular cages, block designs and generalized polygons
Authors: Araujo‐Pardo Gabriela , Jajcay Robert , Ramos‐Rivera Alejandra , Szőnyi Tamás 
Published: March 2022

AbstractA bipartite biregular ‐graph is a bipartite graph of even girth having the degree set and satisfying the additional property that the vertices in the same partite set have the same degree. An ‐bipartite biregular cage is a bipartite biregular ‐graph of minimum order. In their 2019 paper, Filipovski, Ramos‐Rivera, and Jajcay present lower bounds on the orders of bipartite biregular ‐graphs, and call the graphs that attain these bounds bipartite biregular Moore cages. In our paper, we improve the lower bounds obtained in the above paper. Furthermore, in parallel with the well‐known classical results relating the existence of ‐regular Moore graphs of even girths , and 12 to the existence of projective planes, generalized quadrangles, and generalized hexagons, we prove that the existence of an ‐Steiner system yields the existence of a bipartite biregular ‐cage, and, vice versa, the existence of a bipartite biregular ‐cage whose order is equal to one of our lower bounds yields the existence of an ‐Steiner system. Moreover, with regard to the special case of Steiner triple systems, we completely solve the problem of determining the orders of ‐bipartite biregular cages for all integers . Considering girths higher than 6, we relate the existence of generalized polygons (quadrangles, hexagons, and octagons) to the existence of ‐, ‐, ‐, ‐ and ‐bipartite biregular cages, respectively. Using this connection, we also derive improved upper bounds for the orders of other classes of bipartite biregular cages of girths 8, 12, and 14.
Using social network analysis as a tool in action research
Authors: Paterson Susan , McInerney Elizabeth E. W. , Evans Scotney D. 
Published: March 2022

AbstractThe following paper presents case examples of one research team's use of social network analysis (SNA) with three different collaboratives in South Florida: (a) a Collective Impact initiative seeking to end youth homelessness, (b) a university collaborative of campus organizations working towards Black students' concerns, and (c) a movement network of local social justice organizations. The research team used SNA to assess the level of connectivity of three different community coalitions. While research questions were slightly different for each collaborative, each project asked about the frequency of communication between organizations to determine connectivity. Results vary between case examples. Both the Youth Homeless Collaboration and the Black Student Association used Gephi to analyze results, while The Community Partnership used R to measure network centrality. The paper concludes with a general discussion of challenges related to using SNA as an action research tool, as well as the role of power in organizational networks.
A model based on endorectal ultrasonography predicts lateral lymph node metastasis in low and middle rectal cancer
Authors: Yan Li , Weifeng Zhou , Qin Wang , Jinping Wang 
Published: March 2022

AbstractPurposeTo investigate the risk factors for lymph node (LN) metastasis in low and middle rectal tumors, construct a predictive model and test the model's diagnostic efficacy.MethodsThe clinical and pathological data of 172 patients with rectal cancer confirmed by surgery were retrospectively evaluated, among whom 61 patients were finally included in this study. Patients were divided into positive groups and negative groups based on LN metastasis, and risk factors that might affect LN metastasis were analyzed. Finally, a risk predictive model was constructed based on the weights of each risk factor.ResultsCompared with pathology, the efficacy of diagnosing LN metastasis only according to conventional endorectal ultrasonography (ERUS) features of LN was not high, with sensitivity 67%, specificity 86%, positive predictive value 76%, negative predictive value 80%, and accuracy 79%. Univariate analysis showed that circumferential angle of the tumor, ultrasonic T‐ stage (UT stage), conventional ultrasound features diagnosis of LN metastasis, strain ratio (SR) of tumor were risk factors for LN metastasis, while vascular resistance index of rectal tumor was protective factor. Multivariate analysis showed that UT stage (OR = 7.188, p = 0.049), conventional ultrasound features diagnosis of LN metastasis (OR = 8.010, p = 0.025) and SR (OR = 5.022, p = 0.031) were independent risk factors for LN metastasis. These risk factors were included in logistic regression analysis and the model was established, Y = −7.3 + 1.9 X10 + 2.1 X11 + 1.6 X13 (Y = Logit[P], P: LN metastasis rate, X10: UT stage, X11: conventional ultrasound features diagnosis of LN metastasis, X13: SR). The receiver operating characteristic (ROC) curve was used to test the model's predictive efficacy, the area under the curve was 0.95, sensitivity: 95%, specificity: 87%. Hosmer–Lemeshow goodness of fit test showed X2 = 6.015, p = 0.65 (p > 0.05), indicating that the model had a high predictive value.ConclusionEvaluation of perirectal LN metastasis only based on conventional ERUS features of LN was not effective enough. UT stage of tumor, conventional ultrasound features diagnosis of LN metastasis and SR were independent risk factors for LN metastasis. The predictive model had good assessment efficacy and had certain clinical application value.
Saturated buffer design flow and performance in Illinois
Authors: Chandrasoma Janith , Christianson Reid , Cooke Richard Andrew , Davidson Paul C. , Lee DoKyoung , Christianson Laura 
Published: March 2022

AbstractThere are few peer‐reviewed studies documenting saturated buffer annual nitrate (NO3) removal or that have assessed the federal practice standard design criteria. Drainage flow, NO3, and dissolved reactive phosphorus (DRP) were monitored at three saturated buffers in Illinois, USA, for a combined 10 site‐years. Nitrate loss reduction averaged 48 ± 19% with removals of 3.5–25.2 kg NO3–N ha−1 annually. Median DRP concentrations at all sampling locations were at the analytical detection limit of 0.01 mg L−1. The current design paradigm (i.e., USDA practice standard) prescribes there should be no flow bypassing the saturated buffer at flow rates that are ≤5% of the peak drainage system flow rate. The drainage coefficient–based and Manning's equation‐based peak flow estimates were higher and lower, respectively, than the observed annual peaks in all years. This illustrated inherent uncertainty introduced early in the design process, which can be further compounded by dynamic in‐buffer hydrology. The percentage of the observed peak flow rate at which bypass initiated ranged across an order of magnitude between sites (4.4–8.1% of peak flow rate at one site and 42–49% of peak at another) despite the buffers providing relatively similar NO3 removal. Bypass at one site (SB2) was related to the concept of “antecedent buffer capacity filled,” which was defined as the 5‐d average water depth in the middle control structure chamber expressed as a relative percentage of the bypass stop log height. This design flow analysis serves as a call to further evaluate predictive relationships and design models for edge‐of‐field practices.
Wellness of hospitalists and hospital medicine advanced practice providers during the COVID‐19 pandemic, 2020–2021
Authors: Dugani Sagar B. , Fischer Karen M. , Schroeder Darrell R. , Geyer Holly L. , Maniaci Michael J. , Croghan Ivana T. , Kashani Daniel , Burton M. Caroline 
Published: March 2022

AbstractBackgroundThe early phase of the coronavirus disease 2019 (COVID‐19) pandemic had a negative impact on the wellness of hospitalists and hospital medicine advanced practice providers (APPs). However, the burden of the pandemic has evolved and the change in hospitalist and hospital medicine APP wellness is unknown.ObjectiveTo evaluate the longitudinal trend in wellness of hospitalists and hospital medicine APPs during the COVID‐19 pandemic and guide wellness interventions.Design, Setting and ParticipantsBetween May 4, 2020, and June 6, 2021, we administered three surveys to Internal Medicine hospitalists (physicians) and hospital medicine APPs (nurse practitioners and physician assistants) at 16 Mayo Clinic hospitals in four U.S. states.MeasurementsWe evaluated the association of hospitalist and hospital medicine APP characteristics with PROMIS® measures of global wellbeing‐mental health, global wellbeing‐social activities and relationships, anxiety, social isolation, and emotional support, using logistic and linear regression models.ResultsThe response rates were 52.2% (n=154/295; May 2020), 37.1% (n=111/299; October 2020) and 35.5% (n=114/321; May 2021). In mixed models that included hospitalist and hospital medicine APP characteristics and survey period, APPs, compared with physicians, had lower odds of top global wellbeing‐social activities and relationships (adjusted odds ratio 0.42 [0.22–0.82]; p = .01), whereas survey period showed no association. The survey period showed an independent association with higher anxiety (May 2020 vs. others) and higher social isolation (October 2020 vs. others), whereas profession showed no association. Concern about contracting COVID‐19 at work was significantly associated with lower odds of top global wellbeing‐mental health and global wellbeing‐social activities and relationships, and with higher anxiety and social isolation. Hospitalist and hospital medicine APP characteristics showed no association with levels of emotional support.ConclusionsIn this longitudinal assessment of hospitalists and hospital medicine APPs, concern about contracting COVID‐19 at work remained a determinant of wellness. The trend for global wellbeing, anxiety, and social isolation may guide wellness interventions.
Provider preferences for delivery of HIV care coordination services: results from a discrete choice experiment
Authors: Zimba Rebecca , Fong Chunki , Conte Madellena , Baim‐Lance Abigail , Robertson McKaylee , Carmona Jennifer , Gambone Gina , Nash Denis , Irvine Mary 
Published: March 2022

AbstractIntroductionThe PROMISE study was launched in 2018 to assess and document the implementation of changes to an existing HIV Care Coordination Programme (CCP) designed to address persistent disparities in care and treatment engagement among persons with HIV in New York City. We evaluated provider endorsement of features of the CCP to understand drivers of engagement with the programme.MethodsWe used a discrete choice experiment to measure provider endorsement of four CCP attributes, including: (1) how CCP helps with medication adherence, (2) how CCP helps with primary care appointments, (3) how CCP helps with issues other than primary care and (4) where CCP visits take place (visit location). Each attribute had three to four levels. Our primary outcomes were relative importance and part‐worth utilities, measures of preference for the levels of the four CCP program attributes, estimated using a hierarchical‐Bayesian multinomial logit model. All non‐medical providers in the core CCP positions of patient navigator, care coordinator and programme director or other administrator from each of the 25 revised CCP‐implementing agencies were eligible to participate.ResultsWe received responses from 152 providers, 68% of whom identified as women, 49% identified as Latino/a, 34% identified as Black and 60% were 30–49 years old. Visit location (28.6%, 95% confidence interval [CI] 27.0–30.3%) had the highest relative importance, followed by how staff help with ART adherence (24.3%, 95% CI 22.4–26.1%), how staff help with issues other than primary care (24.2%, 95% CI 22.7–25.7%) and how staff help with primary care appointments (22.9%, 95% CI 21.7–24.1%). Within each of the above attributes, respectively, the levels with the highest part‐worth utilities were home visits 60 minutes from the program or agency (utility 19.9, 95% CI 10.7–29.0), directly observed therapy (utility 26.1, 95% CI 19.1–33.1), help with non‐HIV specialty medical care (utility 26.5, 95% CI 21.5–31.6) and reminding clients about and accompanying them to primary care appointments (utility 20.8, 95% CI 15.6–26.0).ConclusionsOngoing CCP refinements should account for how best to support and evaluate the intensive CCP components endorsed by providers in this study.
Men missing from the HIV care continuum in sub‐Saharan Africa: a meta‐analysis and meta‐synthesis
Authors: Nardell Maria F. , Adeoti Oluwatomi , Peters Carson , Kakuhikire Bernard , Govathson‐Mandimika Caroline , Long Lawrence , Pascoe Sophie , Tsai Alexander C. , Katz Ingrid T. 
Published: March 2022

AbstractIntroductionMen are missing along the HIV care continuum. However, the estimated proportions of men in sub‐Saharan Africa meeting the UNAIDS 95‐95‐95 goals vary substantially between studies. We sought to estimate proportions of men meeting each of the 95‐95‐95 goals across studies in sub‐Saharan Africa, describe heterogeneity, and summarize qualitative evidence on factors influencing care engagement.MethodsWe systematically searched PubMed and Embase for peer‐reviewed articles published between 1 January 2014 and 16 October 2020. We included studies involving men ≥15 years old, with data from 2009 onward, reporting on at least one 95‐95‐95 goal in sub‐Saharan Africa. We estimated pooled proportions of men meeting these goals using DerSimonion‐Laird random effects models, stratifying by study population (e.g. studies focusing exclusively on men who have sex with men vs. studies that did not), facility setting (healthcare vs. community site), region (eastern/southern Africa vs. western/central Africa), outcome measurement (e.g. threshold for viral load suppression), median year of data collection (before vs. during or after 2017) and quality criteria. Data from qualitative studies exploring barriers to men's HIV care engagement were summarized using meta‐synthesis.Results and discussionWe screened 14,896 studies and included 129 studies in the meta‐analysis, compiling data over the data collection period. Forty‐seven studies reported data on knowledge of serostatus, 43 studies reported on antiretroviral therapy use and 74 studies reported on viral suppression. Approximately half of men with HIV reported not knowing their status (0.49 [95% CI, 0.41–0.58; range, 0.09–0.97]) or not being on treatment (0.58 [95% CI, 0.51–0.65; range, 0.07–0.97]), while over three‐quarters of men achieved viral suppression on treatment (0.79 [95% CI, 0.77–0.81; range, 0.39–0.97]. Heterogeneity was high, with variation in estimates across study populations, settings and outcomes. The meta‐synthesis of 40 studies identified three primary domains in which men described risks associated with engagement in HIV care: perceived social norms, health system challenges and poverty.ConclusionsPsychosocial and systems‐level interventions that change men's perceptions of social norms, improve trust in and accessibility of the health system, and address costs of accessing care are needed to better engage men, especially in HIV testing and treatment.