bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between Serum Fatty Acids and Pregnancy in PCOS Women Undergoing Ovulation Induction
Authors: Li Mingyue , Tian Ye , Lv Yonghuan , Xu Yanping , Bai Xiaohong , Zhang Huijuan , Wang Yanxia , Song Xueru 
Published: March 2022

Abstract
Background: Long-term dietary fat intake is thought to affect metabolism and pregnancy of polycystic ovary syndrome (PCOS) patients, and the type of fatty acids one consumes plays an important role. Previous studies mostly used questionnaires to analyze the type and proportion of fatty acids. In this study, serum fatty acids were measured by the gas chromatograph-mass spectrometry method before ovulation induction to explore the influence of serum fatty acids on pregnancy in PCOS when undergoing ovulation induction.Methods: This prospective study included ninety-one PCOS patients. We investigated serum fatty acid profiles using the gas chromatograph-mass spectrometry method. We compared the fatty acids between the pregnancy group and the non-pregnancy group and explored the influence of the fatty acids on live births and pregnancy loss. Results: Petroselinic acid in the pregnancy group was higher than in the non-pregnancy group (4.99% vs. 3.35%, P = 0.009), and nervonic acid was lower in the pregnancy group than in the non-pregnancy group (0.24% vs. 0.29%, P = 0.014). The following trans fatty acids were significantly lower in the pregnancy group than in the non-pregnancy group: trans-10-heptadecenoic acid, trans-vaccenic acid, trans-7-nonadecenoic acid, trans-11-eicosenoic acid, and brassidic acid. The level of polyunsaturated fatty acids in the live birth group was significantly higher than the pregnancy loss group (16.95% vs. 14.06%, P = 0.027). Among individual PUFAs, the levels of linoleic acid (P = 0.043), docosapentaenoic acid (P = 0.015), alpha-linolenic acid (P = 0.040) and eicosapentaenoic acid (P = 0.032) were higher in the live birth group than in the pregnancy loss group. After adjusting for infertility duration, age, and body mass index, our findings suggested a positive association between pregnancy and petroselinic acid and an inverse association between pregnancy and nervonic acid, trans-10-heptadecenoic acid, trans-vaccenic acid, trans-7-nonadecenoic acid, trans-11-eicosenoic acid, and brassidic acid and pregnancy.Conclusions: Our findings indicate that serum trans fatty acids and nervonic acid are inversely associated with pregnancy. Serum petroselinic acid and polyunsaturated fatty acids are beneficial to pregnancy.
Complex Trait Analysis of Human Gut Microbiome-Active Traits in Sorghum bicolor: a new category of human health traits in food crops
Authors: Yang Qinnan , Haute Mallory Van , Korth Nate , Sattler Scott , Toy John , Rose Devin , Schnable James , Benson Andrew 
Published: March 2022

Abstract
Several bioactive components of the human diet have major effects on composition and function of the gut microbiome, but no systematic framework exists for understanding variation in microbiome-active components amid the vast amount of genotypic and phenotypic variation within a given species of food crop. Here we present a powerful new approach for complex trait analysis of Microbiome-Active Traits (MATs) in food crops. Capitalizing on a novel automated in vitro microbiome screening (AiMS) methodology to quantify human gut microbiome phenotypes after fermentation of grain from genetically diverse lines, we show how microbiome phenotypes can be used as quantitative traits for genetic analysis. Quantitative Trait Locus (QTL) analysis of AiMS-based phenotypes across grain samples from 294 sorghum (Sorghum bicolor) recombinant inbred lines identified significant QTLs at 10 different genomic regions that collectively control MATs affecting 16 different microbial taxa. Segregation analysis and validation in Near-Isogenic Lines (NILs) confirmed that overlapping QTL peaks for microbiome phenotypes, seed color, and tannin concentration are driven by variation in the Tan2 (chromosome 2) and Tan1 (chromosome 4) regulators of the tannin biosynthetic pathway. Candidate genes at other QTLs suggest that variation in a diverse array of plant molecules can drive MATs.
Assessment of clinical effect of long-term administration of maintenance temozolomide therapy in patients with IDH1/2-wildtype glioblastoma
Authors: Ohno Makoto , Miyakita Yasuji , Takahashi Masamichi , Yanagisawa Shunsuke , Tamura Yukie , Narita Yoshitaka 
Published: March 2022

Abstract
PurposeWe aimed to explore the clinical impact of long-term maintenance temozolomide (TMZ) on glioblastoma (GBM) patient outcomes. MethodsWe included 41 patients with isocitrate dehydrogenase (IDH) 1/2-wildtype GBM, who completed 12 cycles of TMZ between June 2006 and December 2019. Associations between the Karnofsky performance status at 12 cycles (KPS at 12 cycles), residual tumor at 12 cycles, MGMT promoter methylation status, maintenance therapy regimen, or maintenance TMZ beyond 12 cycles and outcomes were assessed.ResultsThe median progression-free survival and median survival time were 25.0 and 45.1 months. Multivariate analysis based on KPS at 12 cycles, residual tumor at 12 cycles, maintenance therapy regimen, maintenance TMZ beyond 12 cycles, and the MGMT promoter methylation status revealed that KPS at 12 cycles ≥ 80 was significantly associated with increased survival after completing 12 cycles (p = 0.0007). The median survival time for 26 patients with KPS at 12 cycles ≥ 80 was significantly longer than that for 15 those with KPS at 12 cycles < 80 (89.3 months vs. 30.7 months: p < 0.0001). The 5-year survival rate for patients with KPS at 12 cycles ≥ 80 was 57.0%. The median survival after first progression was 11.9 months in 29 patients who had tumor progression.ConclusionsPatients who completed 12 cycles of TMZ with KPS at 12 cycles ≥ 80 had an extremely favorable OS, suggesting these patients could receive maximum benefits from prolonged TMZ. Long-term maintenance TMZ does not appear to negatively affect survival after tumor progression.
The Study on the Clinico-pathological Spectrum of Non-neoplastic and Neoplastic Lesions in Cholecystectomy Specimens at a Tertiary Care Centre
Authors: Chaudhary Aishwarya , Bhattacharya Aarti B 
Published: March 2022

Background: Most commonly used surgical procedure for gall-bladder pathology is cholecystectomy. Gall-bladder diseases incidence has increased over the past decade and are cause for a number of histopathological changes like pre-neoplastic conditions and ultimately culminating into the neoplasia. Histopathologic examination of the specimen serves as the absolute diagnosis of the non-neoplastic and neoplastic lesions as pre-operative imaging techniques fail to identify the lesions
Aim: To analyse the clinico-pathological spectrum of various non- neoplastic and neoplastic lesions
occurring in cholecystectomy specimens with and without gall bladder calculus.
Materials & Method: An observational, cross-sectional study was conducted between 2019 to 2020 at a tertiary care centre in Safedabad, Barabanki, UP. A total of 135 cholecystectomy specimens were evaluated for histopathological examination. After histopathological reporting all cases were clinicopatholically related. Data was analysed using SPSS software, the demographic data were presented as frequency, percentage; continuous variables with mean and standard deviation.
Results: 74.8% were females (n=101) and 25.2% were males (n=34) with mean age of 42.96 years. Gall-bladder stone was present in 85.2% of patients (n=115) and absent in 14.8% patients (n=20). Neoplastic lesion in 7 of the patients, 5 patients with adenocarcinoma, 1 patient with adenosquamous carcinoma and 1 patient with papillary adenocarcinoma. Gall-bladder carcinoma were diagnosed in our study; the poorly differentiated GBC revealed high Ki67 Score.
Conclusion: Gall-bladder diseases can have a varied presentation both clinically and histopathologically. Hence, a complete and meticulous macroscopic and microscopic examination of all cholecystectomy specimens should be mandatory for better patient care.
A produção acadêmica sobre o Turismo Religioso e a COVID-19:
Authors: Da Silva Cruz Bruno , José dos santos Junior João 
Published: March 2022

A produção acadêmica abordando a temática do turismo religioso tem sido crescente nos últimos anos. Particularmente em 2020 e 2021 onde verifica-se o crescimento de estudos e a consequente relevância dessa área. Sobretudo em 2020 quando o mundo foi atingido pela grave pandemia de Covid-19. Dessa forma, a temática do turismo religioso se encontra também impactada pela referida pandemia, assim, foram necessária medidas sanitárias e o isolamento social imposto para a contenção do vírus afetando diversos segmentos turísticos O presente trabalho se utilizou de uma pesquisa exploratório-descritiva com abordagem quantitativa e como metodologia a bibliometria a respeito do tema, utilizando como ferramenta a base de dados Scopus, a fim observar os impactos ocasionados pela crise pandêmica no atendimento aos praticantes de turismo sob a motivação religiosa, bem como compreender a pertinência do assunto por meio da apresentação de material publicado a respeito do tema. Os resultados indicam a importância e a relevância da temática na contemporaneidade e também a importância de pesquisas práticas sobretudo no contexto brasileiro que possam esclarecer pontos ainda não muito bem aprofundados sobre a temática. Sobretudo porque a abordagem a esse conteúdo se utiliza de bibliografia recente, os autores deste trabalho pretenderam apresentar um panorama destas publicações no contexto pandêmico, estimando que possa também servir como apoio para pesquisas posteriores.
Palavras-chave: Turismo religioso. Pandemia. Bibliometria.
Impact of Cerebral Oxygen Saturation Monitoring on Short-term Neurodevelopmental
Outcomes in Neonates with Encephalopathy - A Prospective
Cohort Study
Authors: Tewari Vishal Vishnu , Kumar Ashutosh , Kurup Arjun , Daryani Hitesh , Saxena Apoorv 
Published: March 2022

Background:
Near-infrared spectroscopy (NIRS) has been used for monitoring cerebral oxygen saturation (rSO2) in neonates. There is a lack of data from low-middle income countries (LMIC) setting of cerebral rSO2 in neonates with encephalopathy of diverse etiologies. This study aimed to monitor cerebral rSO2 using NIRS in encephalopathic neonates to maintain the rSO2 be-tween 55 to 85 % in the first 72 hours of admission to improve short-term neurodevelopmental out-comes (NDO).

Materials and Methods:
This prospective cohort study enrolled encephalopathic neonates with hy-poxic-ischemic encephalopathy (HIE) and non-HIE etiologies into 8 clinical categories. The cere-bral rSO2 was monitored and targeted to be between 55 to 85 %, with predefined actions and man-agement alterations over 72 hours. The neurodevelopmental assessment was conducted at 3, 6, and 9-12 months corrected age. Moreover, the motor and mental developmental quotients (MoDQ) (MeDQ) were recorded and compared to historical control.

Results:
A total of 120 neonates were enrolled and assessed for NDO. The MoDQ (mean ± SD) was 92.55 ± 14.85, 93.80 ± 13.20, 91.02 ± 12.69 and MeDQ (mean ± SD) was 91.80 ± 12.98, 91.80 ± 13.69, 88.41 ± 11.60 at 3, 6 and 9-12 months. The MoDQ and MeDQ scores of the historic cohort at 12 months were 86.35 ± 20.34 and 86.58 ± 18.27. The mean difference [MD (95 %CI)] for MoDQ was - 4.670 (- 8.48 to - 0.85) (p=0.0165) and for MeDQ was - 1.83 (- 5.26 to 1.6) (p=0.29). There was a negative correlation between the composite developmental quotient (CoDQ) with mean rSO2 and a positive correlation with cerebral fractional tissue oxygen extraction (CFTOE). Neonates with HIE and neonatal encephalopathy (NE) (n=37/120) had the lowest motor and mental DQ on neuro-developmental assessment. Clinical categories, neonatal meningitis (NM), and intraventricular hemorrhage (IVH) improved in DQ scores over the study period.

Conclusion:
Monitoring and maintaining cerebral rSO2 between 55-85 % through appropriate management changes improved neurodevelopmental scores at the 12-month follow-up in neonates with encephalopathy caused by varied etiologies.
Herbal Medicines as Potential Immune Boosters against Coronavirus Diseases
Authors: Chime Salome Amarachi , Madumere Chika Phoebe 
Published: March 2022

Abstract:Coronavirus disease COVID-19 is causing havoc globally, infecting millions of people and has led to the deaths of people in thousands. COVID-19 attacks persons with low immune systems, especially neonates and geriatrics. Hence, boosting immunity may be one of the best options during this pandemic. There is a need to explore the possible herbal drugs to boost the immunity of people as a result of the rising cases of deaths due to COVID-19. However, the rationale for the use of herbal drugs is that each herb has the possibility of treating many health conditions. A single herb could have antiviral, antibacterial, and anti-inflammatory properties. Herbs may be one possible source of a true cure for COVID-19. Herbal drugs are from renewable sources and pose less danger of possible adverse effects compared to synthetic drugs. Because COVID-19 has no true cure presently, man should resort to herbal drugs given by nature. Herbal drugs are highly potent and efficacious; hence, the early men treated their ailments with herbs. However, their use has been limited by poor pharmaceutical design into dosage forms that would be acceptable to people. Herbal drugs could be formulated as teas, decoctions, infusions, and, more recently, tablets, capsules, microparticles, nanoparticles, and phytosomes, amongst others. Different herbal plants with possible immune booster effects will be discussed in this work, and how they can be formulated into stable and acceptable dosage forms will be explored.
Evaluation of Antimicrobial Activity of Thymbra spicata L. var. spicata Essential
Oil as a Potential Source of Herbal Medicine
Authors: Şahiner Aslı , Aksoy Sevinç , Yapar Evren Algın , Cengiz Gökhan , Halat Ece , Ateş Mustafa 
Published: March 2022

Background:
Since ancient times, human kind has used plants for their flavor and essence and
especially for medical purposes; they are also used as food sources. Turkey, due to its geographical location, is home to many varieties of species of medicinal and aromatic plants. Aromatic and medicinal plants
produce essential oils in the form of secondary metabolites. These essential oils are being used in the
food, cosmetic, and pharmaceutical industries. Due to the various side effects of synthetic agents, the use
of essential oils as antimicrobial agents comes to the fore.

Objective:
The purpose of this study was to determine the essential oil composition of Thymbra spicata
L. var. spicata collected from the Gaziantep Region of Turkey and to evaluate its antimicrobial efficacy
against microorganism species commonly encountered in food, cosmetic, and pharmaceutical industries.

Methods:
In this study, the antimicrobial effect of the volatile oil obtained from dried leaves of Thymbra
spicata L. var. spicata, traditionally known as Zahter, was investigated. For this purpose, volatile oil was
obtained from the leaves of the plant by steam vapor distillation method. Antimicrobial efficacy tests were
conducted against microorganisms; Staphylococcus aureus, Enterococcus hirae, Enterococcus faecalis,
Listeria monocytogenes, Escherichia coli, Klebsiella pneumoniae, Proteus hauseri, Pseudomonas aeruginosa, Salmonella typhimurium, and Candida albicans.

Results:
Results of the experiments showed that the volatile oil obtained from Thymbra spicata L. var.
spicata had a cidal effect on selected pathogenic microorganisms even at low concentrations.

Conclusion:
This study showed that the high carvacrol content of the T. spicata L. var. spicata grown in
the Gaziantep region of Turkey is a promising source of antimicrobial raw materials in the pharmaceutical, cosmetic, and food industries.
Pengembangan Lembar Kerja Peserta Didik (LKPD) Berbasis Inkuiri Terbimbing Pada Materi Fungi Kelas X SMA
Authors: Estitika Estitika , Haryanto Haryanto , Murni Pinta 
Published: March 2022

This study aims to develop LKPD based on Guided Inquiry for Class X Fungi Materials in SMA. The development model used in this research is the Plomp development model which consists of three stages, namely; (1) initial investigation, (2) development and manufacture of prototypes, and (3) assessment. The LKPD was tested on tenth-grade students of SMA IT Diniyyah Al-Azhar Jambi City and biology subject teachers. The results of the design expert's assessment, it was found that the LKPD design was very feasible, with a score of 61 or 95.31%. Meanwhile, from the results of the material expert assessment, it was found that the material on the LKPD was very feasible, with a score of 110 or 86%. The results of individual trials, small group trials, and large-group trials, it was found that LKPD has a very practical level of practicality, with the acquisition of practicality scores of 34.67, 36.40 and 34.60, respectively. Likewise, the results of the practicality assessment by the teacher showed that the LKPD had a very practical level of practicality, with a practicality score of 35. It was concluded that the LKPD based on Guided Inquiry on Fungic Materials was very feasible and practical to use in learning activities.
Keywords: Development, LKPD, Guided Inquiry, Fungi Material

Abstrak. Penelitian ini bertujuan mengembangkan LKPD berbasis Inkuiri Terbimbing Materi Fungi Kelas X SMA. Model pengembangan yang digunakan dalam penelitian ini adalah model pengembangan Plomp yang terdiri dari tiga tahapan, yaitu; (1) investigasi awal, (2) pengembangan dan pembuatan prototype, dan (3) penilaian. LKPD diujicobakan kepada siswa kelas X SMA IT Diniyyah Al-Azhar Kota Jambi dan guru mata pelajaran biologi. Hasil penilaian ahli desain, didapatkan bahwa desain LKPD sudah sangat layak, dengan perolehan skor sebesar 61 atau 95,31%. Sementara dari hasil penilaian ahli materi, didapatkan bahwa materi pada LKPD sudah sangat layak, dengan perolehan skor sebesar 110 atau 86%. Hasil ujicoba perorangan, uji coba kelompok kecil, dan ujicoba kelompok besar, didapatkan bahwa LKPD memiliki tingkat kepraktisan sangat praktis, dengan perolehan skor praktikalitas masing-masing sebesar 34,67, 36,40 dan 34,60. Begitupula hasil penilaian praktikalitas oleh guru didapatkan bahwa LKPD memiliki tingkat kepraktisan sangat praktis, dengan perolehan skor praktikalitas sebesar 35. Disimpulkan bahwa LKPD berbasis Inkuiri Terbimbing Materi Fungi sudah sangat layak dan praktis untuk digunakan dalam kegiatan pembelajaran.
Kata kunci: Pengembangan, LKPD, Inkuiri Terbimbing, Materi Fungi
Bidirectional nitrogen transfer, nodulation, and growth in an intercropping system of Eucalyptus and Dalbergia odorifera
Authors: Yao Xianyu , Goodale Uromi , Yang Mei , Liao Liangning , Yu Sufang , Wang Shengqiang , Ye Shaoming 
Published: March 2022

We measured bidirectional N transfer and quantified the amount of
transferred N between Eucalyptus urophylla × grandis (Eucalyptus) and
Dalbergia odorifera (Dalbergia), to determine whether the facilitation
process from N transfer could improve Eucalyptus productivity and
nodulation of Dalbergia. A 15N leaf-labeling study was conducted by
using a pot experiment with Dalbergia and , and 15N was traced in the
labeled species as well as in neighboring trees at 90, 135 and 180 days
after labeling. Bidirectional N occurred between Eucalyptus and
Dalbergia, the amount of net transferred N was 21.8–127.0 mg plant-1 N
from Dalbergia to Eucalyptus, which was equal to 1.5–21.2 % of the
total N accumulated in Eucalyptus plants to increase the biomass of
Eucalyptus. The results also showed that the nodule number of Dalbergia
increased by 19.4–107.4 % in the intercropping system and further
improved its N2-fixation. The concentration of soil nitrogen, especially
the concentration of N-NH4+, was a major factor affecting N transfer in
this system. This study indicated that the advantage in Eucalyptus and
legume intercrops relates to ‘complementary N use’, which provide a
significant amount of N required for Eucalyptus productivity, and
maintain ecological sustainability.
Analisis Kemampuan Bernalar Siswa SMA Dalam Memaknai Permasalahan Integral Berbasis Konteks
Authors: Rahmi Afifah , Hairi Anisa Putri , Lukman Alphiyani , Nasution Andrea Arifsyah 
Published: March 2022

Materi integral merupakan salah satu materi pokok dalam kurikulum matematika di Sekolah Menengah Atas. Dalam penelitian ini, siswa dituntut untuk memiliki kemampuan bernalar. Kemampuan tersebut sangat dibutuhkan dalam penyelesaian masalah integral, khususnya pada permasalahan luas daerah di bawah kurva. Hal tersebut tentunya membutuhkan pemahaman konsep, kemampuan penalaran dan interpretasi. Pada kenyataannya, banyak siswa merasa kesulitan untuk mengatasi permasalahan integral. Akibatnya, siswa mengalami banyak kekeliruan dalam menyelesaikan masalah terkait dengan luas daerah di bawah kurva. Pada artikel ini penulis mencoba untuk menjelaskan secara deskriptif tentang bagaimana siswa menggunakan kemampuan awal mereka pada permasalahan berbasis konteks. Penelitian ini dilakukan di kelas XI yang menduduki semester kedua yang terdiri dari 40 siswa. Pengumpulan data diperoleh melalui tes awal (Student’s Worksheet), wawancara, dan catatan lapangan. Wawancara dilakukan dengan tujuan mendapatkan informasi mengenai bagaimana siswa menyelesaikan permasalahan integral yang disajikan. Hasil dari kegiatan tersebut menunjukan bahwa kemampuan siswa umumnya tidak dapat membantu mereka dalam menyelesaikan permasalahan integral berbasis konteks. Dalam hal ini, penulis menemukan bahwa beberapa siswa tidak dapat menyelesaikan permasalahan; sementara itu beberapa siswa lainnya menerapkan cara lain, seperti dengan menggunakan rumus dan menuangkan dengan kata-kata. [ANALISIS KEMAMPUAN BERNALAR SISWA SMA DALAM MEMAKNAI PERMASALAHAN INTEGRAL BERBASIS KOTEKS
Tailoring Fibre Structure Enabled by X-ray Analytics for Targeted Biomedical Applications
Authors: Schoeller Jean , Avaro Jonathan T. , Maurya Anjani K. , Rossi René M. , Neels Antonia 
Published: March 2022

The rising interest in designing fibres via spinning techniques combining the properties of various polymeric materials into advanced functionalised materials is directed towards targeted biomedical applications such as drug delivery, wearable sensors or tissue engineering. Understanding how these functional polymers exhibit multiscale structures ranging from the molecular level to nano-, micro-and millimetre scale is a key prerequisite for their challenging applications that can be addressed by a non-destructive X-ray based analytical approach. X-ray multimodalities combining X-ray imaging, scattering and diffraction allow the study of morphology, molecular structure, and the analysis of nano-domain size and shape, crystallinity and preferential orientation in 3D arrangements. The incorporation of X-ray analytics in the design process of polymeric fibers via their nanostructure under non-ambient conditions (i.e. temperature, mechanical load, humidity…) allows for efficient optimization of the fabrication process as well as quality control along the product lifetime under operating environmental conditions. Here, we demonstrate the successful collaboration between the laboratory of Biomimetic Textiles and Membranes and the Center of X-ray Analytics at Empa for the design, characterisation and optimisation of advanced functionalised polymeric fibrous material systems.