bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro cytotoxicity against breast cancer using biogenically synthesized gold and iron oxide nanoparticles derived from the hydroethanolic extract of Salvia officinalis L
Authors: El-Rafie Hanaa M. , El-Aziz Salem M. Abd , Zahran Magdy K. 
Published: September 2022

AbstractNanotechnology has a real-world impact on every aspect of life. Many researchers have been drawn to the biosynthesis of gold and iron oxide nanoparticles (Au-NPs and SPIONS) because they have a wide range of life applications. In this work, a single-step environmentally friendly biosynthesis of Au-NPs and SPIONS is reported by reducing solutions of gold aureate and ferric chloride is reported for the first time using the hydroethanolic extract (HEE) of Salvia officinalis (S. officinalis), an edible plant found in Egypt. The phytochemicals present in HEE were responsible for the reduction as well as stabilization of these nanoparticles. Before using the HEE, it was phytochemically screened for its constituents. Qualitatively, the HEE was found to have comparable levels of phenolics, flavonoids, tannins, proteins, carbohydrates, terpenoids, steroids, and polysaccharides. Quantitatively, total phenolics (236.91 ± 2.15 mg GAE/g extract), flavonoids (91.38 ± 0.97 mg QE/g extract), tannins (101.60 ± 1.33 mg/g extract), proteins (284.62 ± 2.65 mg/g extract), carbohydrates (127.73 ± 1.68 mg/g extract), soluble sugars (52.3 ± 0.67 mg/g extract), and polysaccharides (75.43 ± 1.01 mg/g extract) were estimated. In addition, HPLC analysis revealed the identification of seven phenolic compounds [ferulic (67.26%), chlorogenic (3.12%), caffeic (3.11%), p-coumaric (1.13%), protocatechuic (0.65%), catechin (0.69%), rosmarinic (0.53%)] and three flavonoids [apigenin (5.29%), quercetin-7-O-glucoside (3.39%), and luteolin-7-O-rutinose (2.01%)]. The characterization of the biosynthesized NPs was confirmed by Fourier transform infrared (FT-IR) spectroscopy, UV–Vis absorption spectroscopy, X-ray diffraction (XRD), and transmission electron microscopy (TEM). In vitro cytotoxic studies showed that Au-NPs, SPIONS, and HEE have an inhibitory effect on the growth of human breast cancer (MCF-7) cells at an IC50 of 6.53, 6.97, and 26.12 µg mL−1, respectively, by comparison with the standard drug (Doxorubicin) effect (0.18 µg mL−1).
Cilostazol Alleviates NLRP3 Inflammasome–Induced Allodynia/Hyperalgesia in Murine Cerebral Cortex Following Transient Ischemia: Focus on TRPA1/Glutamate and Akt/Dopamine/BDNF/Nrf2 Trajectories
Authors: Zaki Omnia S. , Nassar Noha N. , Abdallah Dalaal M. , Safar Marwa M. , Mohammed Reham A. 
Published: September 2022

Abstract

Global cerebral ischemia/reperfusion (I/R) provokes inflammation that augments neuropathic pain. Cilostazol (CLZ) has pleiotropic effects including neuroprotection in several ravaging central disorders; nonetheless, its potential role in transient central ischemic-induced allodynia and hyperalgesia has not been asserted before. Rats were allocated into 4 groups; sham, sham + CLZ, and 45 min-bilateral carotid occlusion followed by a 48 h-reperfusion period either with or without CLZ (50 mg/kg; p.o) post-treatment. CLZ prolonged latency of hindlimb withdrawal following von Frey filaments, 4 °C cold, and noxious mechanical stimulations. Histopathological alterations and the immunoexpression of glial fibrillary acidic protein induced by I/R were reduced by CLZ in the anterior cingulate cortex (ACC) area, while, CLZ enhanced intact neuronal count. Meanwhile, CLZ modulated cerebral cortical glutamate, dopamine neurotransmission, and transient receptor potential ankyrin 1 (TRPA1). CLZ anti-inflammatory potential was mediated by the downregulated p65 NF-κB and sirtuin-1 enhancement to reduce nucleotide-binding domain-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein (ASC), active caspase-1, and interleukin-1β, indicative of inflammasome deactivation. It also revealed an antioxidant capacity via boosting nuclear factor E2-related factor (Nrf2) enhancing glutathione through forkhead box protein O3a (FOXO3a) reduction. Additionally, CLZ triggered neuronal survival by promoting the p-content of Akt, TrkB, and CREB as well as BDNF content. A novel approach of CLZ in hindering global cerebral I/R–mediated neuropathy is firstly documented herein to forward its adjunct action via deactivating the NLRP3 inflammasome, besides enhancing Nrf2 axis, neuronal survival, and dopamine neurotransmission as well as inhibiting TRPA1 and excitotoxicity.
Graphical abstract
Former Training Relieves the Later Development of Behavioral Inflexibility in an Animal Model Overexpressing the Dopamine Transporter
Authors: Edemann-Callesen Henriette , Glienke Maximilian , Akinola Esther Olubukola , Lieser Maike Kristin , Habelt Bettina , Hadar Ravit , Bernhardt Nadine , Winter Christine 
Published: September 2022

AbstractA range of dopamine-dominating neuropsychiatric disorders present with cognitive deficits. In accordance, the dopamine transporter overexpressing rat model (DAT-tg rat) displays cognitive deficits by means of behavioral inflexibility and learning disabilities. It remains to be investigated when cognitive deficits emerge, due to the inherent DA irregularities, during the life course of the DAT-tg rat and what may relieve symptoms. The Morris water maze (MWM) was used to assess cognitive abilities in three cohorts of DAT-tg rats. In the first cohort, the development of cognitive deficits was assessed by repeatedly testing animals in the MWM at postnatal day (PND) 35, 60, and 90. In the second and third cohort, pharmacological interventions and transcranial direct current stimulation (tDCS) were tested in adult animals to understand what drives, and thus relieves, the deficits. Minor differences were observed between DAT-tg rats and control rats at PND 35 and 60, whereas cognitive deficits fully emerged at PND 90. A high dosage of methylphenidate diminished both behavioral inflexibility and improved learning abilities in adult rats. Interestingly, rats subjected early in life to the MWM also displayed improved behavioral flexibility as compared to rats naïve to the paradigm. Cognitive deficits gradually develop over time and fully emerge in adulthood. Pharmacological modulation of the ubiquitous DAT overexpression overall improves deficits in adult rats, whereas early training decreases later development of behavioral inflexibility. Thus, former training may constitute a preventive avenue that alters some aspects of cognitive deficits resulting from inherent DA abnormalities.
Incorporating barriers in scenarios for energy efficiency improvement and promoting renewable energy in the Bulgarian residential sector
Authors: Konidari Popi , Nikolaev Angel 
Published: September 2022

AbstractThe progress in achieving targets for energy efficiency (EE) and renewable energy sources (RES) is hindered by a set of barriers linked with the end-users (social, educational, cultural, economic, and institutional), but previously, the effect of these barriers was only rarely quantified and no comprehensive methodology to do so is available. This paper, through a step-by-step methodology, examines the development of scenarios for the Bulgarian residential sector until 2030, focusing on the combination of available – for this sector – EE and RES technologies, after incorporating these barriers with the use of the HERON Decision Support Tool (HERON-DST). Two more research tools are used, LEAP (modeling tool) and AMS (multi-criteria evaluation method). Six different scenarios, three of which address barriers, were developed for LEAP. All scenarios are evaluated with the AMS method against a set of criteria/sub-criteria regarding their overall performance under the particular national framework. This results in the identification of the most appropriate (EE/RES) scenario for the country, i.e., addresses behavioral barriers and performs better (one with the highest AMS score) than the others under the particular national framework. This scenario promotes building shell improvement, efficient heating, and cooling in the Bulgarian residential sector. Its policy mixture mainly through financial incentives and more demanding building codes handles social, institutional, and economic barriers linked with end-users behavior. Conclusions concern the methodology, its outcomes, and future use.
Beating Around the Bush – Swedish Schoolgirls’ Coping Strategies and Impact Processes of Sexual Harassment
Authors: Eek-Karlsson Liselotte , Berggren Jan , Torpsten Ann-Christin 
Published: September 2022

AbstractThe aim of this study is to contribute knowledge about Swedish school girls’ perspectives of sexual harassment and their relations to peers when exposed to violence in terms of sexual harassment, both online and offline. The empirical data was collected through pair interviews where 28 girls participated. The theoretical framework was based on coping strategies that people use when facing stressful situations. The transcribed empirical data was read and interpreted based on what appeared to be important and decisive related to the theoretical framework. The found strategies are divided into three main categories, namely, problem-focused behavioural strategies, emotion-focused cognitive strategies, and emotion-focused behavioural strategies. The results show that the girls use different strategies depending on if the harassment occurs online or offline and if the perpetrator is known or unknown. Problem-focused cognitive strategies are used due to the specific context. Emotion-focused cognitive strategies are foremost used if the perpetrator is a known friend.
Hydrodynamic Variability of an Intermittently Closed Estuary over Interannual, Seasonal, Fortnightly, and Tidal Timescales
Authors: Harvey Madeleine E. , Giddings Sarah N. , Pawlak Geno , Crooks Jeffrey A. 
Published: September 2022

AbstractSmall low-inflow intermittently closed estuaries are common in Mediterranean climates worldwide; however, despite their important contributions to ecosystem services and coastal resilience, their dynamics have been less well studied relative to classical (i.e., deeper, persistent freshwater inflow) estuaries. It is known that infragravity wave propagation into these estuaries can induce strong currents and that closures lead to stagnating flows and declining water quality; however, how the estuarine circulation (tidal and subtidal) dynamically drives and responds to these conditions remains largely unknown. Here we analyze over 4 years of hydrodynamic observations in Los Peñasquitos Lagoon, a low-inflow, intermittently closed estuary in Southern California, to examine wave propagation into the estuary, sill accretion, and the estuarine circulation response over tidal, fortnightly, seasonal, and interannual time scales, providing an unprecedented view as to how these systems respond to changing forcing. Wave observations near the estuary inlet show that wave energy inside the inlet, which contributes to sill accretion, is dependent on water level relative to the sill height and has a tidal variation due to wave-current interactions. Tidal phase averages of conditions during open, pre-closure, spring, neap, and closed conditions highlight the large dynamic range that these estuaries experience. During open, low sill conditions, circulation and stratification are consistent with stratification-induced periodic straining and subtidal exchange varies with the fortnightly cycle as observed in many classical estuaries. However, as the sill grows, tidal circulation weakens and becomes strongly sheared and the subtidal exchange no longer scales with a classical theoretical pressure-friction balance.
The Vestibulocerebellum and the Shattered Self: a Resting-State Functional Connectivity Study in Posttraumatic Stress Disorder and Its Dissociative Subtype
Authors: Rabellino Daniela , Thome Janine , Densmore Maria , Théberge Jean , McKinnon Margaret C. , Lanius Ruth A. 
Published: September 2022

Abstract
The flocculus is a region of the vestibulocerebellum dedicated to the coordination of neck, head, and eye movements for optimal posture, balance, and orienting responses. Despite growing evidence of vestibular and oculomotor impairments in the aftermath of traumatic stress, little is known about the effects of chronic psychological trauma on vestibulocerebellar functioning. Here, we investigated alterations in functional connectivity of the flocculus at rest among individuals with post-traumatic stress disorder (PTSD) and its dissociative subtype (PTSD + DS) as compared to healthy controls. Forty-four healthy controls, 57 PTSD, and 32 PTSD + DS underwent 6-min resting-state MRI scans. Seed-based functional connectivity analyses using the right and left flocculi as seeds were performed. These analyses revealed that, as compared to controls, PTSD and PTSD + DS showed decreased resting-state functional connectivity of the left flocculus with cortical regions involved in bodily self-consciousness, including the temporo-parietal junction, the supramarginal and angular gyri, and the superior parietal lobule. Moreover, as compared to controls, the PTSD + DS group showed decreased functional connectivity of the left flocculus with the medial prefrontal cortex, the precuneus, and the mid/posterior cingulum, key regions of the default mode network. Critically, when comparing PTSD + DS to PTSD, we observed increased functional connectivity of the right flocculus with the right anterior hippocampus, a region affected frequently by early life trauma. Taken together, our findings point toward the crucial role of the flocculus in the neurocircuitry underlying a coherent and embodied self, which can be compromised in PTSD and PTSD + DS.
Participatory monitoring in community-based fisheries management through a gender lens
Authors: House Jenny , Kleiber Danika , Steenbergen Dirk J. , Stacey Natasha 
Published: September 2022

AbstractIn small-scale fisheries management, the significance of participation is widely recognised but we are still learning how this can be better operationalised to include different groups, such as women or Indigenous peoples. Participatory monitoring is one tool which has been used to increase participation in fisheries management. The aim of this review is to use critical interpretive synthesis to examine the literature on participatory monitoring within community-based fisheries management from a gender perspective. The synthesis identified and discussed several key areas: reasons presented in the literature for engaging with the themes of gender or participatory monitoring, gendered aspects of participatory monitoring, knowledge valuation and prioritisation in management, replicability and transparency of programme or research methods, and marginalisation narratives. Our findings show the complexities of conducting gender-aware participatory monitoring. Participatory monitoring has the potential to be a transformative and empowering process if the power dynamics involved are considered and addressed.
A unified way to solve IVPs and IBVPs for the time-fractional diffusion-wave equation
Authors: Rodrigo Marianito 
Published: September 2022

AbstractThe time-fractional diffusion-wave equation is revisited, where the time derivative is of order $$2 \nu $$

2
ν

and $$0 < \nu \le 1$$

0
<
ν
≤
1

. The behaviour of the equation is ‘diffusion-like’ (respectively, ‘wave-like’) when $$0 < \nu \le \frac{1}{2}$$

0
<
ν
≤

1
2

(respectively, $$\frac{1}{2} < \nu \le 1$$

1
2

<
ν
≤
1

). Two types of time-fractional derivatives are considered, namely the Caputo and Riemann-Liouville derivatives. Initial value problems and initial-boundary value problems are studied and handled in a unified way using an embedding method. A two-parameter auxiliary function is introduced and its properties are investigated. The time-fractional diffusion equation is used to generate a new family of probability distributions, and that includes the normal distribution as a particular case.
Date Palm as Source of Nutraceuticals for Health Promotion: a Review
Authors: Al-Okbi Sahar Y. 
Published: September 2022

AbstractPurpose of ReviewChronic diseases are problematic to health professional specially when using drugs throughout the course of life with un-tolerated side effects. Returning to nature through using nutraceuticals might have both protective and therapeutic effects. Date palm was claimed to be a good source of such nutraceuticals or functional food ingredients. The purpose of the present review was to spot light on the different phytochemicals, phytonutrients, and remedial effects of date palm (Phoenix dactyliferaL.) in a goal to be utilized in form of nutraceuticals. The possible mechanisms of action of the remedial effects were among the aim of the study.Recent FindingsA protein hydrolyzate prepared from date seed could prevent DNA mutation and susceptibility to cancer. In addition to cancer prevention, date palm fruit improved the treatment outcome of cancer pediatric patients and possesses anti-angiogenic activity as one of the important anticancer mechanisms of action. On the other hand, date seed extracts was recently reported to protect from ulcerative colitis. It seems that all the aforementioned remedial effect might be ascribed to immunoregulatory effect of date palm. These findings proposed that date palm is beneficial for health.SummaryDate palm fruit is a rich source of vitamins, minerals, dietary fibers, energy, and easily digestible and absorbable sugars that instantaneously replenish and revitalize the body specially after fasting condition. Mineral contents in date fruits include potassium, phosphorus, magnesium, and calcium. Diverse health claims were reported to belong to various parts of the tree including the edible part of fruits, the seeds, the leaves, spathe (an envelope-like structure that encloses male and female date palm flowers), and pollen grains due to the presence of different bioactive constituents. The main phytochemicals and phytonutrients reported in date palms are phenolic compounds, carotenoids, sterols, anthocyanins, and others. In folk medicine, date palm fruits are used for enhancing immunity and treating gastrointestinal tract disorders, edema, bronchitis, wound, cancer, as well as infectious diseases.However, the exact health benefits and remedial effects of date palm were not fully and deeply investigated. The present review focused on the bioactive constituents and the reported health benefits of date palm and proposed mechanism of action.
Analysis of Heading Stability due to Interactions between Pectoral and Caudal Fins in Robotic Boxfish Locomotion
Authors: Qiu Hongcheng , Chen Lingkun , Ma Xinshuo , Bi Shusheng , Wang Bo , Li Tiefeng 
Published: September 2022

AbstractInvestigating the interaction between fins can guide the design and enhance the performance of robotic fish. In this paper, we take boxfish as the bionic object and discuss the effect of coupling motion gaits among the two primary propulsors, pectoral and caudal fins, on the heading stability of the body. First, we propose the structure and control system of the bionic boxfish prototype. Second, using a one/two-way fluid–structure interaction numerical method, we analyse the key parameters of the prototype and discuss the influence of pectoral and caudal motion gaits on the hydrodynamic performance. Finally, effect of the pectoral and caudal interactions on heading stability of the prototype is systematically analyzed and verified in experiments. Results show that the course-deviating degree, oscillation amplitudes of yawing, rolling, and pitching exhibited by the prototype are smaller than that caused by single propulsor when the motion gaits of both pectoral and caudal fins are coordinated in a specific range. This paper reveals for the first time the effect of interactions between pectoral and caudal fins, on the stability of body's course by means of Computational Fluid Dynamics and prototype experiments, which provides an essential guidance for the design of robotic fish propelled by multi-fins.
Contexts Rather Than Close Readings of Latin American Literature
Authors: Pollard Scott 
Published: September 2022

This essay reviews the following works:Borges and the Literary Marketplace: How Editorial Practices Shaped Cosmopolitan Readings. By Nora C. Benedict. New Haven, CT: Yale University Press, 2021. Pp. ix+ 365. $35.00 hardcover. ISBN: 9780300251418.Oriente no es una pieza de museo: Jorge Luis Borges, la clave orientalista y el manuscrito de “Qué es el budismo.” By Sonia Betancort. Salamanca: Ediciones Universidad de Salamanca, 2018. Pp. 316. Paperback. ISBN: 9788490129678.Artesana de sí misma: Gabriela Mistral, una intelectual en cuerpo y palabra. By Claudia Cabello Hutt. West Lafayette, IN: Purdue University Press, 2018. Pp. vii + 240. $45.00 paperback. ISBN: 9781557538079.Jorge Luis Borges in Context. Edited by Robin Fiddian. Cambridge: Cambridge University Press, 2020. Pp. viii + 285. $116.00 hardcover. ISBN: 9781108470445.A History of Chilean Literature. Edited by Ignacio López-Calvo. Cambridge: Cambridge University Press, 2021. Pp. xii + 654. $115.00 hardcover. ISBN: 9781108487375.Ascent to Glory: How “One Hundred Years of Solitude” Was Written and Became a Global Classic. By Alvaro Santana-Acuña. New York: Columbia University Press, 2020. Pp. 384. $28.00 paperback. ISBN: 9780231184335.
Refinement of AlphaFold2 models against experimental and hybrid cryo-EM density maps
Authors: Alshammari Maytha , Wriggers Willy , Sun Jiangwen , He Jing 
Published: September 2022

Abstract
Recent breakthroughs in deep learning-based protein structure prediction show that it is possible to obtain highly accurate models for a wide range of difficult protein targets for which only the amino acid sequence is known. The availability of accurately predicted models from sequences can potentially revolutionise many modelling approaches in structural biology, including the interpretation of cryo-EM density maps. Although atomic structures can be readily solved from cryo-EM maps of better than 4 Å resolution, it is still challenging to determine accurate models from lower-resolution density maps. Here, we report on the benefits of models predicted by AlphaFold2 (the best-performing structure prediction method at CASP14) on cryo-EM refinement using the Phenix refinement suite for AlphaFold2 models. To study the robustness of model refinement at a lower resolution of interest, we introduced hybrid maps (i.e. experimental cryo-EM maps) filtered to lower resolutions by real-space convolution. The AlphaFold2 models were refined to attain good accuracies above 0.8 TM scores for 9 of the 13 cryo-EM maps. TM scores improved for AlphaFold2 models refined against all 13 cryo-EM maps of better than 4.5 Å resolution, 8 hybrid maps of 6 Å resolution, and 3 hybrid maps of 8 Å resolution. The results show that it is possible (at least with the Phenix protocol) to extend the refinement success below 4.5 Å resolution. We even found isolated cases in which resolution lowering was slightly beneficial for refinement, suggesting that high-resolution cryo-EM maps might sometimes trap AlphaFold2 models in local optima.