bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of long-chain omega-3 polyunsaturated fatty acids on reducing anxiety and/or depression in adults; A systematic review and meta-analysis of randomised controlled trials
Authors: Kelaiditis Christos F. , Gibson E. Leigh , Dyall Simon C. 
Published: October 2022

AbstractFirst-line treatment for anxiety and depressive disorders comprises pharmacotherapy and psychotherapy; options not safe, effective, or suitable for all. Mounting evidence suggests that the omega-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic (EPA), docosahexaenoic (DHA) and docosapentaenoic (DPAn-3) acids are promising therapeutic options. However, meta-analyses of randomised controlled trials (RCTs) have produced inconsistent findings. This review assesses for the first time the efficacy of omega-3 PUFAs against the severity of anxiety and depression symptoms, measured by validated scales, with specific consideration of methodological issues encountered in this area. PubMed, CINAHL, PsycINFO, Cochrane Library and Web of Science were searched for eligible RCTs administering omega-3 PUFAs against anxiety and/or depression. This study adopts the PRISMA guidelines. Ten RCTs comprising 1509 participants were included in the quantitative synthesis. EPA-enriched interventions at ≥60% of total EPA+DHA were associated with significant reduction in depression severity, compared to placebo (SMD: -0.32; 95% CI: -0.59, -0.06; p=0.02); however, EPA doses of ≥2000 mg/day were not (SMD: -0.11; 95% CI: -0.43, 0.20; p=0.48). Only 10 RCTs fulfilled the eligibility criteria, and there were some concerns regarding bias and population heterogeneity, highlighting the lack of high-quality RCTs in this area. Overall, these results support previous observations where EPA at proportions ≥60% of total EPA+DHA, up to 2000 mg, reduces depression scores. However, more trials are needed which specifically consider the unique nature of this type of research to elucidate the therapeutic potential of EPA, DHA and DPAn-3.
Microbial Community Interactions on a Chip
Authors: Juang Duane. S. , Wightman Wren E. , Lozano Gabriel L. , Barkal Layla J. , Yu Jiaquan , Garavito Manuel F. , Hurley Amanda , Venturelli Ophelia S. , Handelsman Jo , Beebe David J. 
Published: October 2022

AbstractMultispecies microbial communities drive most ecosystems on Earth. Chemical and biological interactions within these communities can affect survival of individual members and the entire community. However, the prohibitively high number of possible interactions within a microbial community has made the characterization of factors that influence community development challenging. Here we report a Microbial Community Interaction (μCI) device to advance the systematic study of chemical and biological interactions within a microbial community. The μCI creates a combinatorial landscape made up of an array of triangular wells interconnected with circular wells, which each contains either a different chemical or microbial strain, generating chemical gradients and revealing biological interactions.Bacillus cereusUW85 containing GFP provided the “target” readout in the triangular wells, and antibiotics or microorganisms in adjacent circular wells are designated the “variables”. The μCI device revealed that gentamicin and vancomycin are antagonistic to each other in inhibiting the targetB. cereusUW85, displaying weaker inhibitory activity when used in combination than alone. We identified three-member communities constructed with isolates from the plant rhizosphere that increased or decreased growth ofB. cereus. The μCI device enables both strain-level and community-level insight. The scalable geometric design of the μCI device enables experiments with high combinatorial efficiency, thereby providing a simple, scalable platform for systematic interrogation of three-factor interactions that influence microorganisms in solitary or community life.
The Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening
Authors: Chopra Ashima , Bauman Joseph D. , Ruiz Francesc X. , Arnold Eddy 
Published: October 2022

ABSTRACTX-ray crystallographic fragment screening (XCFS) uses fragment-sized molecules (∼60 – 300 Da) to access binding sites on proteins that may be inaccessible to larger drug-like molecules (>300 Da). Previous studies from our lab and others have shown that fragments containing halogen atoms have a higher binding occurrence compared to non-halogenated fragments. Specifically, we showed that 4-halopyrazoles hold potential for predicting the likelihood of success of a XCFS campaign. Here, we designed the Halo Library containing 46 halogenated fragments (including the “universal fragment” 4-bromopyrazole). The basis of fragment selection was presence of (at least) one halogen atom, and binding to or inhibitory activity against (at least) two targets in literature. The library was screened against crystals of HIV-1 reverse transcriptase with drug rilpivirine, yielding an overall hit rate of 26%. Two new binding sites were discovered in addition to previously reported sites, and several hot spots were identified (i.e., sites with multiple fragment hits). This small library may thus provide a convenient tool for assessing feasibility of a target for XCFS, mapping hot spots and cryptic sites, as well as finding fragment binders that can be useful for developing drug leads.
STING activation depends on ACBD3 and other phosphatidylinositol 4-phosphate-regulating proteins
Authors: Luteijn Rutger D. , van Terwisga Sypke R. , Ver Eecke Jill E. , Onia Liberty , Zaver Shivam A. , Woodward Joshua J , Raulet David H. , van Kuppeveld Frank J.M. 
Published: October 2022

AbstractSTING induces transcription of pro-inflammatory genes upon activation at the Golgi apparatus. Many of the regulators involved in STING activation are unknown. We found that ACBD3 and other phosphatidylinositol 4-phosohate (PI4P) regulating proteins play a critical role in STING activation. We show that proper STING localization and activation at the Golgi depended on ACBD3 and PI4KB expression. Furthermore, depleting PI4P by inactivating PI4KB or overexpressing Sac1 diminished STING activation. STING signalling was also regulated by the lipid-shuttling protein OSBP, which removes PI4P from the Golgi. OSBP inhibition by the FDA-approved antifungal itraconazole and other OSBP inhibitors greatly enhanced STING activation by increasing the levels of STING-activating phospholipids. Itraconazole-enhanced STING activation resulted in a hundred to thousand-fold increased expression of interferon-beta and other cytokines. In conclusion, the phospholipid PI4P is critical for STING activation and manipulating PI4P levels is a promising therapeutic strategy to alter the STING immune response.
Genetic Dissection of Mutual Interference between Two Consecutively Learned Tasks inDrosophila
Authors: Zhao Jianjian , Zhang Xuchen , Zhao Bohan , Wang Liyuan , Hu Wantong , Zhong Yi , Li Qian 
Published: October 2022

AbstractAnimals can continuously learn different tasks to adapt to changing environments and therefore have strategies to effectively cope with inter-task interference, including both proactive interference (Pro-I) and retroactive interference (Retro-I). Many biological mechanisms are known to contribute to learning, memory, and forgetting for a single task, however, mechanisms involved only when learning sequential different tasks are relatively poorly understood. Here, we dissect the respective molecular mechanisms of Pro-I and Retro-I between two consecutive associative learning tasks inDrosophila. Pro-I is more sensitive to inter-task interval (ITI) than Retro-I. They occur together at short ITI (<20 min), while only Retro-I remains significant at ITI beyond 20 min. Acutely overexpressing Corkscrew (CSW), an evolutionarily conserved protein tyrosine phosphatase SHP2, in mushroom body (MB) neurons reduces Pro-I, whereas acute knockdown of CSW exacerbates Pro-I. Such function of CSW is further found to rely on the γ subset of MB neurons and the downstream Raf/MAPK pathway. In contrast, manipulating CSW does not affect Retro-I as well as a single learning task. Interestingly, manipulation of Rac1, a molecule that regulates Retro-I, does not affect Pro-I. Thus, our findings suggest that learning different tasks consecutively triggers distinct molecular mechanisms to tune proactive and retroactive interference.
Privacy concerns and avoidance behaviour towards data-driven online behavioural advertising
Authors: Jain Shradha , Purohit H.C. 
Published: October 2022

PurposeWith the developments of the digital era and considerable developments in ICT, advertisers are leveraging data-driven forms of online advertising to target consumers individually. The present study integrates privacy concerns with the constructs from the persuasion knowledge model to investigate consumer avoidance of online behavioural advertising (OBA).Design/methodology/approachThe study employed an online survey method for data collection using a sample size of 345. Reliability and validity of the measurement scales were ensured, and hypotheses developed were tested through PLS-SEM using SMART PLS.FindingsThe results show that persuasion knowledge is a significant predictor of perceived benefits, perceived risks and privacy concerns. Also, privacy concern was found to significantly mediate persuasion knowledge-avoidance behaviour and perceived risk-avoidance behaviour. On the other hand, the perceived benefit was not found significant in influencing privacy concerns for OBA.Practical implicationsThe present study is one of the initial attempts to understand the level of knowledge Indian consumers hold about OBA and how they evaluate and respond to these data-driven forms of advertising. The current study helps advance knowledge of the field and the theories used. Future studies might look at the effect of various demographic and psychographic aspects on consumer avoidance of OBA.Originality/valueAs the country is shifting to digital, it becomes really important to understand the privacy concerns that people perceive in regard with the current advertising practices.
A new approach for histological classification of breast cancer using deep hybrid heterogenous ensemble
Authors: Zerouaoui Hasnae , Idri Ali , El Alaoui Omar 
Published: October 2022

PurposeHundreds of thousands of deaths each year in the world are caused by breast cancer (BC). An early-stage diagnosis of this disease can positively reduce the morbidity and mortality rate by helping to select the most appropriate treatment options, especially by using histological BC images for the diagnosis.Design/methodology/approachThe present study proposes and evaluates a novel approach which consists of 24 deep hybrid heterogenous ensembles that combine the strength of seven deep learning techniques (DenseNet 201, Inception V3, VGG16, VGG19, Inception-ResNet-V3, MobileNet V2 and ResNet 50) for feature extraction and four well-known classifiers (multi-layer perceptron, support vector machines, K-nearest neighbors and decision tree) by means of hard and weighted voting combination methods for histological classification of BC medical image. Furthermore, the best deep hybrid heterogenous ensembles were compared to the deep stacked ensembles to determine the best strategy to design the deep ensemble methods. The empirical evaluations used four classification performance criteria (accuracy, sensitivity, precision and F1-score), fivefold cross-validation, Scott–Knott (SK) statistical test and Borda count voting method. All empirical evaluations were assessed using four performance measures, including accuracy, precision, recall and F1-score, and were over the histological BreakHis public dataset with four magnification factors (40×, 100×, 200× and 400×). SK statistical test and Borda count were also used to cluster the designed techniques and rank the techniques belonging to the best SK cluster, respectively.FindingsResults showed that the deep hybrid heterogenous ensembles outperformed both their singles and the deep stacked ensembles and reached the accuracy values of 96.3, 95.6, 96.3 and 94 per cent across the four magnification factors 40×, 100×, 200× and 400×, respectively.Originality/valueThe proposed deep hybrid heterogenous ensembles can be applied for the BC diagnosis to assist pathologists in reducing the missed diagnoses and proposing adequate treatments for the patients.
Innovation orientation and government service innovation: an empirical investigation on the UAE government agencies
Authors: Alosani Mohammed Saleh , Al-Dhaafri Hassan Saleh , Mousa Nasr Mohammed 
Published: October 2022

Purpose
The purpose of this study is to empirically investigate the influence of innovation orientation, information sharing and service innovation in United Arab Emirates (UAE) government institutions.

Design/methodology/approach
Using a convenient sample approach, data was obtained from the UAE government agencies. The various constructions were analysed using partial least squares structural equation modelling in SmartPLS.

Findings
The results show that innovation orientation has an impact on service innovation. Knowledge sharing also functions as a moderator in the link between innovation orientation and government service innovation.

Originality/value
This paper contributes both theoretically and practically. To the best of the authors’ knowledge, it is one of the first studies to examine direct correlations between innovation orientation and government service innovation, giving evidence of the moderating function of knowledge sharing in innovation orientation and service innovation.
The environment, social and governance (ESG) activities and profitability under COVID-19: evidence from the global banking sector
Authors: Yuen Mui Kuen , Ngo Thanh , Le Tu D.Q. , Ho Tin H. 
Published: October 2022

PurposeThis study investigated the impacts of the environment, social and governance (ESG) and its components on global bank profitability considering the COVID-19 outbreak.Design/methodology/approachThis study used a system generalized method of moments (GMM) proposed by Arellano and Bover (1995) to investigate the relationship between ESG and bank profitability using an unbalanced sample of 487 banks from 51 countries from 2006 to 2021.FindingsThe findings generally found that ESG activities may reduce bank profitability, thus supporting the trade-off hypothesis that adopting ESG standards could increase bank costs while lowering profitability. In addition, there is a U-shaped relationship between ESG and bank profitability, suggesting that ESG activities can help improve bank performance in the long term. Such an effect is the first time observed in the global banking sector. This study’s results are robust across different models and settings (e.g., developed vs. developing countries, different levels of profitability, and samples with vs without US banks).Practical implicationsThis study provides empirical evidence to support many countries' sustainable development policies. It also provides empirical incentives for bank managers to be more ESG-oriented.Originality/valueThis study provides a better understanding of the roles of ESG activity and its components in the global banking system, considering the recent crises.
Antecedents of psychological ownership among family hotel employees
Authors: Azila-Gbettor Edem Maxwell , Blomme Robert Jan , Honyenuga Ben Q. , Kil Ad 
Published: October 2022

PurposeThis paper examines the mediating process of enhancing employees' psychological ownership among family hotel employees.Design/methodology/approachA total of 1,005 employees from 197 budget-to-three-star family hotels took part in the study by completing an either self-reported or interviewer questionnaire. The respondents were selected using a convenient sampling technique. A partial least square structural equation was used to analyse the data.FindingsWork engagement and organisational performance were shown to significantly predict psychological ownership, except for counterproductive work behaviour. Both counterproductive work behaviour and organisational performance were found to predict psychological ownership. Finally, the relationship between (1) counterproductive work behaviour and psychological ownership and (2) organisational performance and psychological ownership is mediated by work engagement.Practical implicationsReplication of this model in different countries and other work settings is highly recommended for cross validating the reported findings in this study. The study emphasises the need for family hotel owners to create a conducive work environment devoid of conditions that promote counterproductive work behaviour among employees and encourage them to engage in higher productivity.Originality/valueThis study appears to be one of the first to have investigated a model linking counterproductive work behaviour, performance to psychological ownership through work engagement in the family hotel context.
Pretrial diversion agreements after Andersen’s prosecution: a utilitarian theoretical framework
Authors: Gates Sandra K. 
Published: October 2022

Purpose
Using the ethical consequentialist theory of utilitarianism, this paper aims to demonstrate the correlation between the prosecution of Arthur Andersen LLP and the United States Department of Justice’s (DOJ) increased use of pretrial diversion agreements, both nonprosecution and deferred prosecution agreements (N/DPA) for criminal corporations.

Design/methodology/approach
Through an analysis of previous literature, the United States Justice Manual, and data from the Corporate Prosecution Registry, this study examines the trend of N/DPAs from 1992 to 2021. Specifically, the data is examined to assess whether a pattern exists before and after the 2002 prosecution of Andersen.

Findings
This study finds an exponential increase of N/DPAs after Andersen’s prosecution. The DOJ’s basis for the increased use of these agreements is rooted in the utilitarian theory that the punishment of criminal corporations should deter and rehabilitate behavior while also maximizing the benefit to society (e.g. shareholders, employees and business community). The justice manual, memorandums and public speeches explicitly promote the use of N/DPAs for corporations to minimize collateral damage and the potential for negative societal impact.

Originality/value
This study applies a utilitarian framework to explain the criminal justice system’s increased use of pretrial diversion agreements for criminal corporations.
Work and religion: an exploratory study of Muslim entrepreneurs in the United Arab Emirates
Authors: Tahir Rizwan 
Published: October 2022

Purpose
This study aims to understand how religion impacts the everyday activities of Muslim entrepreneurs in the United Arab Emirates (UAE).

Design/methodology/approach
This qualitative research is grounded on in-depth interviews with 50 entrepreneurs presently living and working in the UAE. When selecting the interviewees, the authors used purposeful sampling to ensure a diverse sample of interviewees with respect to nationality, age, gender and the nature of their business.

Findings
It was found that religion for these Muslim entrepreneurs is highly individualized, leading to our initial impressions that work and religion have no relationship. Nevertheless, following deeper investigation, it was found that religion does shape the everyday entrepreneurial activities of these entrepreneurs. More precisely, the entrepreneurial activities of these Muslim entrepreneurs are impacted by a desire to re-explain their work in religious terms, leading to conflicts between work and religion.

Originality/value
In todays’ competitive environment in the UAE, the workplace is increasingly consuming a considerable amount of individuals’ time, becoming more fundamental to their identity, and incorporating more life factors. However, the aspects impacting work have not been extensively researched, particularly the impact of religion on entrepreneurial endeavors, which represents a different type of work. The current study endeavors to fill this crucial research gap, and by doing so, we bring empirical attention to the relationship proposed yet largely ignored in prior studies.
Positioning products through names: effect of sound symbolism on perception of products with blended brand names
Authors: Arora Sunny Vijay , Kalro Arti D. , Sharma Dinesh 
Published: October 2022

PurposeManagers prefer semantic imbeds in brand names, but extant literature has primarily studied fictitious names for their sound-symbolic perceptions. This paper aims to explore sound-symbolic perceptions of products with blended brand names (BBNs), formed with at least one semantic and one nonsemantic component. Unlike most extant literature, this study not only estimates the effect of vowels and consonants individually on product perceptions but also of their combinations. The boundary condition for this effect is examined by classifying products by their categorization and attributes by their abstractness.Design/methodology/approachThrough a within-subject experiment, this paper tested perceptions of products with BBNs having high-/low-frequency sounds. A mixed-design experiment followed with sound frequency, product-level categorization and attributes’ abstractness as predictor variables.FindingsFor BBNs, vowel sounds convey brand meaning better than the combinations of vowel and consonant sounds – and these convey brand meaning better than consonant sounds. Differences in consumers’ perceptions of products with BBNs occur when the degree of attributes’ abstractness matches product-level categorization, such as when concrete attributes match subordinate-level categorization.Practical implicationsBrand managers/strategists can communicate product positioning (attribute-based) through BBNs created specifically for product categories and product types.Originality/valueThis research presents a comparative analysis across vowels, consonants and their combinations on consumers’ perceptions of products with BBNs. Manipulation of names’ length and position of the sound-symbolic imbed in the BBN proffered additional contributions. Another novelty is the interaction effect of product categorization levels and attributes’ abstractness on sound-symbolic perception.
Engaging with matters that matter: a cross-cultural journey into the financialization of climate change effects
Authors: Chua Wai Fong , Fiedler Tanya 
Published: October 2022

Purpose
The purpose of this paper is to develop a concept of engaged research that promotes research on matters that matter. Engaged research comes to the fore at the margins of accounting where issues are often ill-structured and less well studied. This study empirically illustrates how the principles of engaged research are embodied in practice at the borders of accounting.

Design/methodology/approach
The authors first consider engaged research conceptually, by articulating the philosophical principles upon which such research is grounded. This study argues that engaged research comes to the fore in settings where accounting practices are emergent and uncertainty high. The authors illustrate the “doing” of engaged research by exploring accounting for the financial effects of climate change. The authors conclude by highlighting the integrated form and purpose of engagement and by making suggestions for engaged research of the future.

Findings
Engaged research is characterised by an ontology of becoming, an epistemology of cross-cultural travel and a methodology of co-production. It is enacted through multilingualism, a reflexive dialogue that enables self-others to travel into and experience alternative worlds, as well as through the mediation of knowledge and associated artefacts. Its intent is to promote dialogue and knowledge sharing. This study argues and shows how engaged research is an active entanglement of metatheory, theory, artefacts and the lives of self and others.

Originality/value
This paper reflects on engaged research at the margins of accounting, as well as on how such research is a “becoming”, sociomaterial, co-produced entanglement.