bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher efficacy of resveratrol against advanced breast cancer organoids: A comparison with that of clinically relevant drugs
Authors: Ye Hai‐Shan , Gao Hong‐Fei , Li Hong , Nie Jun‐Hua , Li Ting‐Ting , Lu Meng‐Di , Wu Mo‐Li , Liu Jia , Wang Kun 
Published: June 2022

AbstractThe lack of reliable drugs is a therapeutic challenge of advanced breast cancers (ABCs). Resveratrol (Res) exerts inhibitory effects on breast cancer cell lines and animal models, while its efficacy against individual breast cancer cases remains unknown. This study aims to use ABC‐derived organoids (ABCOs) as the ex vivo therapeutic platform to clarify the effectiveness of resveratrol against different ABC subtypes. Immunohistochemical staining confirmed that the ABCOs maintained their original tumors' ER, PR, HER2, and Ki67 expression patterns. ABCO proliferation and viability tests showed >50% cell death rates in 79.2% (19/24) of Res‐treated, 28.6% (2/7) fulvestrant‐treated, 66.7% (4/6) paclitaxel‐treated, and 66.7% (6/9) gemcitabine‐treated ABCOs. pSTAT3 nuclear translocation was more frequent in Res‐sensitive (17/19; 89.47%) than that (1/5; 20%) of Res‐insensitive ABCOs, which were suppressed upon Res treatment. Statistical analysis revealed a close correlation of STAT3 activation with the efficacy of Res, but not related to tumor receptor expression patterns (ER, PR, HER2) and pathological classification. We demonstrate for the first time the higher efficacy and broader spectrum of Res against different subtypes of ABCOs in comparison with that of conventional antibreast cancer drugs, providing an alternative approach for better management of ABCs.
The cultural dimensions of sustainable development: A cross‐country configurational analysis
Authors: Sedita Silvia Rita , Blasi Silvia , Yang Jiawen 
Published: June 2022

AbstractOur research emphasizes the need to explore the importance of cross‐country cultural differences in shaping sustainable development. We employ the fuzzy set Qualitative Comparative Analysis (fsQCA) to analyze cross‐national data, focusing on the relationship between Hofstede's six cultural dimensions and the sustainable development goals (SDGs) index of 82 countries worldwide. The empirical evidence sustains that the culture influences the modalities through which countries reach sustainable development. We identified four configurations of cultural dimensions associated with high levels of sustainability performance. The analysis informs that there are mainly two possible configurations: the first is characterized by low power distance (PDI) and high individualism, while the second is characterized by high PDI and low individualism. Given the existence of multiple modalities for reaching the same goal, we derive some policy implications to advise policymakers and governments on how to improve the sustainable development of their countries, taking into consideration their cultural characteristics.
Preparation of pH‐Sensitive Molecularly Imprinted Polymer via Dual‐Monomer for Selective Solid‐Phase Extraction of Ribavirin from Human Urine and Pharmaceutical Samples
Authors: Zafarghandi Setareh Samiei , Panahi Homayon Ahmad , Nezhati Mahshid Nikpour 
Published: June 2022

AbstractThe specific molecularly imprinted polymer for ribavirin was fabricated by using 3‐allyloxy‐1, 2‐propanediol and acrylic acid as the functional monomers, divinylbenzene and N, N’‐methylenebisacrylamide as the cross‐linkers, and azobisisobutyronitrile as the initiator. It was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy combined with an energy dispersive X‐ray analyzer, and thermogravimetric analysis. Several factors affecting the extraction of ribavirin, such as pH, contact time, and temperature were also investigated. The molecularly imprinted polymer indicated high sorption capacity (3.1 mg g−1) for ribavirin, and the adsorption equilibrium was established after 15 min. The adsorption isotherm results could be well described with the Freundlich isotherm model. The linear range was 0.5–80 mg L−1, and recoveries ranging from 93 % to 102 % were achieved. The detection limit of ribavirin was identical at 0.82 μg L−1, and the relative standard deviation was 0.265 %. It was successfully used for ribavirin analysis in human urine and pharmaceutical samples.
Oxidation Behavior and Interfacial Bonding Properties of NiCrAl Alloys
Authors: Li Zhiqiang , Song Zhengqi , Li Tinghua , Li Shoubo , You Junheng , Lei Ping , Zhu Donglai , Shang Shanzhai , Zou Jianpeng 
Published: June 2022

AbstractThe oxidation behavior and oxidation kinetics of NiCrAl alloy were studied by XRD, SEM and the thermogravimetric analysis method. The adhesion strength of the films was characterized by micron scratch tester. The results show that the oxide film has not formed at 600 °C and 700 °C, and an oxide layer of Al2O3 has formed at 800 °C. Moreover, an oxide layer composed of Cr2O3 and Al2O3 has formed at 900 °C. After oxidation at 800 °C for 100 h, partial θ‐Al2O3 has transformed to steady‐state α‐Al2O3 and a dense oxide film of Al2O3 with the thickness of about 620 nm has formed on the surface of the NiCrAl alloy. The oxidation kinetics curve of the alloy obeys the parabolic law and there are two oxidation rate constants in the oxidation process. The oxidation rate constant of 1.58×10−4 mg2⋅cm−4⋅h−1 in the early oxidation period (0∼12 h) and the oxidation rate constant of 1.04×10−4 mg2⋅cm−4⋅h−1 in the late oxidation period (12∼100 h) indicate that the oxidation resistance ability of the alloy increases with the extension of oxidation time. With the increase of the oxidation time, the interface bonding strength between the oxide film and the substrate can be improved and reaches 5.21 N at 800 °C for 100 h.
Rheological Characterization of Mixed Aqueous Solutions of Enzymatic Hydrolysis Lignin and Ionic Liquid
Authors: Ma Yingchong , Zheng Huanda , Zheng Laijiu , Wei Ligang , Cai Tao , Zheng Fuer 
Published: June 2022

AbstractHere we present a rheological study of enzymatic hydrolysis lignin (EH lignin) in 1‐butyl‐3‐methylimidazolium chloride ([C4min]Cl) aqueous solutions. The effects of ionic liquid mass fraction, shear rate and temperature on the viscosity and macromolecular chain configuration of EH lignin / C4min] Cl aqueous solution were studied. The results showed that the viscosity of the aqueous solutions increased with the increase of lignin content. The mass percentages of overlapping and winding, responding to divisions of lignin macromolecules existence state, were varied with changing in the temperature and mass percentages of ionic liquid. Increasing the mass of ionic liquid will significantly change the viscosity of lignin solution. Most of the lignin solutions had shear thinning behavior, suggesting that macromolecular chains of lignin moved with orientation to the fluid, and disentangled under the shear force. The viscosity of lignin solution decreased with the increase of temperature, and the viscosity activation energy increased with the increase of lignin or ionic liquid mass fraction.
Monosaccharide Linked Schiff Base Metal Complexes of Cu(II), Zn(II) and Mn(II): Exploring the Antiproliferative Activity and Cell Death Mechanism
Authors: Mondal Shyam Sundar , Jaiswal Namita , Tripathy Rajat Kumar , Bera Partha Sarathi , Chanda Nripen , Behera J. N. , Ghosal Subhas , Saha Tanmoy Kumar 
Published: June 2022

AbstractHerein, a new type of Schiff base ligand, HSL2 (where HSL2=2,2,7,7‐tetramethyltetrahydro‐3aH‐bis[1,3]dioxolo[4,5‐b:4′,5′‐d]pyran‐5‐yl) methyl‐4‐(3,5‐dichloro‐2‐hydroxybenzylidene amino)benzoate) anchored with a monosaccharide unit have been synthesized and characterized by FT‐IR, 1H NMR, and ESI‐MS. The ligand are chelated to metal ions Zn(II) (1), Cu(II) (2), and Mn(II) (3) to from square planar/tetrahedral or octahedral complexes. The DFT studies are carried out to optimize the shapes of the compounds. Moreover, Cu(II) and Mn(II) complexes were also characterized by EPR spectroscopy. The cytotoxicity of the complexes was screened towards three different cell lines A549 (lung cancer), HeLa (cervical cancer), and HT29 (colorectal cancer). These complexes exhibited significant cytotoxicity against three aforementioned cell lines and IC50 values are found in the range of 19.77–23 μM on HeLa cells, 9.42–12.25 μM on A549 cells and 8.84–16 μM on HT29 cells. The cell death mechanism was also studied by employing DNA fragmentation, Hoechst 33342 nuclear staining, and Acridine orange/ Ethidium Bromide (AO/EB) assay. In addition, ROS generation was also evaluated with these metal complexes.
Hydrogen Bonding in 1‐Propanol‐Ethanol Binary Mixture: Experimental and Modeling Approaches
Authors: Swathi P. V. , Abdulkareem U. , Kartha Thejus R , Madhurima V. 
Published: June 2022

AbstractHydrogen bonds between the constituent molecules determine the physical properties of binary liquids. In this work, we explore the nature of hydrogen bonding in ethanol‐propanol system through experimental and computational techniques. The refractive index, dielectric spectroscopy and infrared spectroscopy along with molecular dynamic simulations of 1‐propanol‐ethanol binary system over the entire concentration range are reported here. The excess static permittivity and excess relaxation time shows the evidence of hydrogen bonded multimer structures. The deconvoluted OH peaks from IR spectra indicate the presence of trimers, tetramers and pentamers. The linear decrease in refractive index indicates the absence of caged structures. Molecular Dynamics simulations confirm the presence of the multimers and the absence of caged structures. Radial distribution function shows the binary mixtures exhibit no structural change throughout the concentration range. We also examine the H‐bonding networks present in these systems via graph theoretic analysis.
Highly Efficient Zn(L‐Pro)2 Catalyst for the Synthesis of 2‐Phenyl Benzimidazoles and 2‐Phenyl Benzothiazoles via Aerobic Oxygenation
Authors: Katla Rakhi , Katla Ramesh , Domingues Nelson Luis C. 
Published: June 2022

AbstractThe synthesis of biologically active 2‐substituted benzimidazoles and benzothiazoles was developed using Zn(L‐Pro)2 as catalyst in ethanol at room temperature in an aerobic oxidative cyclization reaction involving o‐phenylenediamine and 2‐aminothiophenol with various substituted aldehydes. This process offers a quick and eco‐friendly way to synthesize a variety of pharmacologically important benzothiazoles and benzimidazoles.
MnO2@MXene/Carbon Cloth as an Anode for Microbial Fuel Cells
Authors: Jiang Demin , Chen Huina , Xie Hao , Liu Haojia , Zeng Mengyuan , Xie Kun , Wang Yuqiao 
Published: June 2022

AbstractHydrophobicity of carbon‐based anodes hinders bacterial adhesion and biofilm formation. Herein, MnO2@MXene coated carbon cloth (CC) was designed as an anode for microbial fuel cells (MFCs). The anode integrated the hydrophilicity and conductivity of MXene with the biocompatibility of MnO2. This unique structure promoted bacterial colonisation and biofilm formation on the anode surface. MnO2@MXene enhanced electricity generation performance and wastewater degradation efficiency owing to the synergistic effect of MXene and MnO2. The MFC achieved a short startup time and an effective extracellular electron transfer process. The MnO2@MXene/CC anode ensured a higher power density and efficient decolourisation in MFCs. The MFC device achieved a high maximum power density of 746.3 mW/m2 and a Congo red decolourisation efficiency of 87.6 % at 48 h. This work offers a potential strategy for the effective degradation of wastewater and recovery of electrical energy.
Modifying the Lithiophilicity of Cu2O/Cu Collector by LiCuO to Restrain Lithium Dendrite Growth
Authors: Zuo Zhongzheng , Huang Xianli , Zhuang Dongmei , Zhao Qiliang , Wang Tao , He Jianping 
Published: June 2022

AbstractLithium dendrite growth has long been considered an obstacle to the practical application of lithium metal battery, which could be efficiently suppressed by increasing the lithiophilicity of Cu collector. Therefore, herein we developed a facile way to prepare LiCuO/Cu composite current collector, which shows better wettability with EC/EDC electrolyte than pure Cu2O layer. X‐ray diffraction (XRD) analysis shows that there is a large amount of LiCuO on the surface of the anode. The nucleation overpotential of LiCuO/Cu composite current collector is only 26 mV in the electrodeposition curve. At a current density of 1 mA/cm2, the Li−Cu cell with the as‐prepared LiCuO/Cu anode, can keep more than 85 % Coulombic efficiency for more than 125 cycles. Impedance spectra of electrodes image show that the impedance of LiCuO/Cu composite current collector is only 60 Ω at the initial stage, which can promote the transfer of Li+ at the collector surface and thus inhibit the formation of lithium dendrites on the electrode surface.
Recent Advances of Carbon Materials in Anodes for Aqueous Zinc Ion Batteries
Authors: Gao Xingyuan , Li Yuyan , Yin Wei , Lu Xihong 
Published: June 2022

AbstractCarbon‐based materials have been successfully applied in the zinc ion batteries to improve the energy storage capability and durability of zinc anodes. In this review, four types of carbon materials (conventional carbons, fiber‐like carbons, carbon nanotubes, graphene and other 2D carbon materials) are introduced based on the electrode preparation, physicochemical property and battery performance. Several modification strategies are also illustrated, such as heteroatom doping, hierarchical design and metal/carbon composites. Besides the discussion of existing issues of zinc anodes, the structure‐performance relationships are analyzed in depth. Finally, conclusive remarks of this review are summarized and prospects of the future improvement are proposed.
Theories of Motivation and Empowerment in Open, Distance, and Digital Education
Authors: Ng Clarence 
Published: June 2022

AbstractMotivation instigates and guides learning in open, distance, and digital education (ODDE). It is indispensable to distance learners’ engagement, persistence, and achievement. A lack of motivation is associated with perennial issues such as early dropout and poor performance in ODDE. This chapter provides an introduction to key theoretical perspectives on motivation, including sociocognitive theories, sociocultural theories, and the concept of perezhivanie. Each perspective provides a unique way for understanding and researching motivation in open and distance learning (ODL). Motivation is discussed as personal attributes internal to the distance learner from a sociocognitive perspective. Drawing attention to social processes and contextual influences, sociocultural theories situate motivation in relevant contexts and highlight motivation as a social, interactive, mediated, and evolving construct. The concept of perezhivanie gives prominence to distance learners’ learning experiences and subjective meanings they derived from personally significant experiences in ODL. This perspective pinpoints motivation that is experiential, reflective, and affect-laden. To advance the goal of empowering distance learners to engage and persist in ODL, these theoretical perspectives are important as they underscore empowerment derived from enabling personal attributes (sociocognitive theories), motivating contexts (sociocultural theories), and personally significant experiences (perezhivanie).
Probing sub-GeV leptophilic dark matter at Belle II and NA64
Authors: Liang Jinhan , Liu Zuowei , Yang Lan 
Published: June 2022

Abstract
An analysis is given of the Belle II sensitivities and NA64 constraints on the sub-GeV Dirac dark matter that interacts with charged leptons. We consider two different types of interactions between sub-GeV Dirac dark matter and the charged leptons: the EFT operators and the light vector mediators. We compute the Belle II mono-photon sensitivities on sub-GeV dark matter with 50 ab−1 data which are expected to be accumulated in the full Belle II runs. Although the Belle II mono-photon sensitivities on the EFT operators are of similar size as the LEP constraints, Belle II can probe new parameter space of the light vector mediator models that are unexplored by LEP. For both the EFT operators and the light vector mediator models, the Belle II mono-photon sensitivities can be several orders of magnitude stronger than the current dark matter direct detection limits, as well as the white dwarf limits. The light vector mediator can also be directly searched for by reconstructing the invariant mass of its di-lepton decay final states at Belle II, which is found to be complementary to the mono-photon channel. We compute the NA64 constraints on the sub-GeV Dirac dark matter and provide analytic expressions of the dark matter cross section in the Weizsäcker-Williams approximation, for the EFT operators, and for the light vector mediator models. We find that the current NA64 data (with 2.84 × 1011 electron-on-target events) provide strong constraints on sub-GeV dark matter. Although the NA64 constraints are found to be about one order of magnitude smaller than the Belle II sensitivities for the EFT operators, NA64 can probe some regions of the parameter space in the light vector mediator models that are beyond the reach of Belle II. We also find that Belle II and NA64 can probe the canonical dark matter annihilation cross section in thermal freeze-out in a significant portion of the parameter space of the models considered.
Sub-subleading soft graviton theorem from asymptotic Einstein’s equations
Authors: Freidel Laurent , Pranzetti Daniele , Raclariu Ana-Maria 
Published: June 2022

Abstract
We identify in Einstein gravity an asymptotic spin-2 charge aspect whose conservation equation gives rise, after quantization, to the sub-subleading soft theorem. Our treatment reveals that this spin-2 charge generates a non-local spacetime symmetry represented at null infinity by pseudo-vector fields. Moreover, we demonstrate that the non-linear nature of Einstein’s equations is reflected in the Ward identity through collinear corrections to the sub-subleading soft theorem. Our analysis also provides a unified treatment of the universal soft theorems as conservation equations for the spin-0,-1,-2 canonical generators, while highlighting the important role played by the dual mass.
Holographic superconductivity in Einsteinian Cubic Gravity
Authors: Edelstein José D. , Grandi Nicolás , Sánchez Alberto Rivadulla 
Published: June 2022

Abstract
We study the condensation of a charged scalar field in a (3 + 1)-dimensional asymptotically AdS background in the context of Einsteinian cubic gravity, featuring a holographic superconductor with higher curvature corrections corresponding to a CFT with a non-vanishing value of the stress tensor three-point function t4. As it was previously noticed for higher dimensional Gauss-Bonnet theory, we observe that the critical temperature of the superconducting phase transition is lowered as the higher curvature coupling grows.
Rings and strings: a basis for understanding subleading colour and QCD coherence beyond the two-jet limit
Authors: Forshaw Jeffrey R. , Holguin Jack , Plätzer Simon 
Published: June 2022

Abstract
Guided by the colour-diagonal structure of collinear singularities, we identify a set of kinematic basis functions that are well suited to the simplification of soft gluon emission amplitudes. In particular, these basis functions, which emerge naturally in the colour flow basis, isolate the subleading colour contributions and improve the statistical convergence of the CVolver amplitude-evolution code. They also allow us to extend current angular-ordered parton showers beyond the azimuthally-averaged, two-jet limit.
General and age-specific fertility rates in non-affective psychosis: population-based analysis of Scottish women
Authors: MacBeth Angus , McSkimming Paula , Bhattacharya Sohinee , Park John , Gumley Andrew , St Clair David , Barry Sarah J. E. 
Published: June 2022

Abstract
Purpose
Women diagnosed with non-affective psychosis have a lower general fertility rate (GFR) and age-specific fertility rate (ASFR) than women in the general population. Contemporary data on GFR in this group remain limited, despite substantive changes in prescribing and management. We calculated contemporary estimates of the GFR and ASFR for women diagnosed with non-affective psychosis compared with the general population of women without this diagnosis.

Methods
A population-based design combined routinely collected historical maternity and psychiatric data from two representative areas of Scotland. Women were included from the NHS Grampian or Greater Glasgow and Clyde areas and were aged 15–44 between 2005 and 2013 inclusive. The ‘exposed’ group had a diagnosis of non-affective psychosis (ICD-10 F20–F29) and was compared to the general population of 'unexposed' women in the same geographical areas.

Results
Annual GFR between 2005 and 2013 for women with non-affective psychosis varied from 9.6 to 21.3 live births/1000 women per year in the exposed cohort and 52.7 to 57.8 live births/1000 women per year in the unexposed cohort, a rate ratio (RR) of 0.28 [p < 0.001; 95% CI (0.24, 0.32)]. ASFR for all 5-year age groups was lower in the exposed cohort than amongst unexposed women.

Conclusion
We highlight continued low fertility rates in women with a diagnosis of non-affective psychosis, despite widespread availability of prolactin-sparing atypical antipsychotics. Accurate estimation of fertility rates remains crucial in developing needs-matched perinatal care for these women. Methodological improvements using routine datasets to investigate perinatal mental health are also urgently needed.