bluuebunny/crossref_metadata_2025_split huggingface dataset:
Latest Oligocene adakitic rocks in western Iran: implications for early crustal thickening and tectonic evolution of the Iran Block
Authors: Liu Yi-Xin , Chen Jian-Lin , Yang Tian-Nan , Hou Zeng-Qian , Zhang Hong-Rui , Yang Zhi-Ming , Yang Zhu-Sen , Aghazadeh Mehraj , Xu Ji-Feng 
Published: September 2022

Adakitic rocks occur in a variety of tectonic settings and are key to understanding the tectonic evolution and geodynamics of orogenic belts. We investigated latest Oligocene (23.5–22.5 Ma) quartz monzonites and granites from the western segment of the Urumieh–Dokhtar magmatic belt in Iran, which are likely to have formed in response to the early stages of Arabia–Eurasia collision. The studied rocks have the geochemical characteristics of typical adakites, such as high SiO
2
(60.18–68.82 wt%) and Sr (499–793 ppm) contents, low Y (8.90–17.1 ppm) and Yb (0.88–1.58 ppm) contents, and high Sr/Y (26.1‒67.8) and (La/Yb)
N
(21.9‒32.9) ratios. They have variable K
2
O (3.88–5.09 wt%), MgO (0.44–2.74 wt%; Mg# = 33.7–52.5), Cr (4.27–40.59 ppm), Ni (4.28–35.68 ppm) and Th (9.56–59.59 ppm) contents, and relatively depleted Sr–Nd isotopic compositions [(
87
Sr/
86
Sr)
i
= 0.70450–0.70516;

ε

Nd
(
t
) = 2.1–2.7]. These characteristics indicate that the quartz monzonites were derived from the partial melting of delaminated lower crust that interacted with mantle peridotite with high MgO, Cr and Ni contents and depleted Sr–Nd isotopic compositions and suggest that the granites were formed by the fractional crystallization of quartz monzonitic magma. The geochemical features of the studied adakitic rocks could therefore have been affected by magmatic processes (e.g. fractional crystallization), which might be misleading in interpretations of their petrogenesis and related tectonic settings. The geochemical features of the studied rocks indicate that the crust of the western segment of the Urumieh–Dokhtar magmatic belt was thickened to
c.
50 ± 4.43 km during the latest Oligocene (
c.
23.5 Ma) as a result of Arabia–Eurasia collision.

Supplementary material:
Whole rock geochemical and Sr–Nd isotopic compositions, and zircon U–Pb and Lu–Hf isotopic data are available at
https://doi.org/10.6084/m9.figshare.c.6188328
Orthogonality Property of the Discreteq-Hermite Matrix Polynomials
Authors: Salem Ahmed , Alzahrani Faris , El-Shahed Moustafa 
Published: September 2022

In this paper, we prove that the solution of the autonomousq-difference systemDqYx=AYqxwith the initial conditionY0=Y0whereAis a constant square complex matrix,Dqis the Jacksonq-derivative and0<q<1, is asymptotically stable if and only ifℜλ<0for allλ∈σAwhereσAis the set of all eigenvalues ofA(the spectrum ofA). This results are exploited to provide the orthogonality property of the discreteq-Hermite matrix polynomials.
Feasibility of a Novel Academic BCMA-CART (HBI0101) for the Treatment of Relapsed and Refractory AL Amyloidosis
Authors: Kfir-Erenfeld Shlomit , Asherie Nathalie , Grisariu Sigal , Avni Batia , Zimran Eran , Assayag Miri , Sharon Tatyana Dubnikov , Pick Marjorie , Lebel Eyal , Shaulov Adir , Cohen Yael C. , Avivi Irit , Cohen Cyrille J. , Stepensky Polina , Gatt Moshe E. 
Published: September 2022

Abstract

Purpose:
AL amyloidosis (AL) treatments are generally based on those employed for multiple myeloma. Anti–B-cell maturation antigen (BCMA) chimeric antigen receptor T (CART)-cell therapy, already approved for multiple myeloma, might be too toxic for patients with AL.

Experimental Design:
Here we describe the ex vivo applicability of a novel in-house, academic anti-BCMA CAR construct on AL primary cells, as well as the safety and efficacy in 4 patients with relapsed/refractory (RR) primary AL, treated in a phase I clinical trial (NCT04720313).

Results:
Three had MAYO stage IIIa cardiac involvement at enrollment. The treatment proved relatively safe, with a short and manageable grade 3 cytokine release syndrome evident in 2 patients and no neurotoxicity in any. Cardiac decompensations, observed in 2 patients, were also short and manageable. The overall hematologic response and complete response rates were observed in all patients with an organ response evident in all four. Within a median follow-up period of 5.2 (2.5–9.5) months, all 4 patients maintained their responses.

Conclusions:
BCMA-CART cells provide a first proof-of-concept that this therapy is safe enough and highly efficacious for the treatment of patients with advanced, RR AL.
Abstract IA020: Reprogramming of myogenic transcription factors in rhabdomyosarcoma
Authors: Ford Heide L. , Hsu Jessica Y. , Danis Etienne P. , Nance Stephanie , O’Brien Jenean H. , Gustafson Annika L. , Wessells Veronica M. , Goodspeed Andrew E. , Talbot Jared C. , Amacher Sharon L. , Jedlicka Paul , Black Joshua C. , Costello James C. , Durbin Adam D. , Artinger Kristin B. 
Published: September 2022

Abstract
Rhabdomyosarcoma, a pediatric malignancy with partial resemblance to undifferentiated skeletal muscle, is characterized by high expression of myogenic-lineage transcription factors such as MYOD1 and MYOG. Despite high expression of these transcription factors, which in normal muscle result in differentiation, RMS cells fail to differentiate, suggesting the presence of factors that inhibit their normal differentiation-promoting functions. In this talk, I will present data that the key muscle transcriptional regulator, SIX1, which in development activates the myogenic regulatory factors (MRFs) and promotes muscle differentiation, in fact inhibits differentiation in fusion-negative (FN) RMS. SIX1 holds FN-RMS cells in a progenitor-like state by altering the chromatin landscape and causing MYOD1, a key MRF, to preferentially bind to regulatory regions of genes permissive to growth rather than differentiation. Loss of SIX1 results in re-localization of MYOD1 to promoters/enhancers of genes associated with differentiation, and further results in increased binding of MYOG at such loci. Altered binding of MYOD1 and MYOG in response to SIX1 loss results in marked inhibition of RMS growth in vivo, via induction of differentiation. These data suggest that SIX1 acts as a master regulatory factor controlling the fate of RMS cells. Data will be presented that suggest dynamic actions of SIX1 and its co-factors throughout normal muscle differentiation, whereby high levels of SIX1 expressed in early muscle differentiation may mimic a transcriptional state seen in RMS. We hypothesize that the specific levels of SIX1, combined with a unique combination of transcriptional co-factors, reprogram genome-wide binding of MRFs to different promoter/enhancer sites at specific developmental time points, and that RMS is trapped in an early developmental state where SIX1 represses differentiation via genome-wide alterations in MRF binding that favor growth. Understanding the co-factors that work with SIX1 to alter chromatin state and MRF binding may enable the discovery of novel targets whose inhibition could serve as a relatively non-toxic treatment to restore normal developmental processes and inhibit RMS progression.
Citation Format: Heide L. Ford, Jessica Y. Hsu, Etienne P. Danis, Stephanie Nance, Jenean H. O’Brien, Annika L. Gustafson, Veronica M. Wessells, Andrew E. Goodspeed, Jared C. Talbot, Sharon L. Amacher, Paul Jedlicka, Joshua C. Black, James C. Costello, Adam D. Durbin, Kristin B. Artinger. Reprogramming of myogenic transcription factors in rhabdomyosarcoma [abstract]. In: Proceedings of the AACR Special Conference: Sarcomas; 2022 May 9-12; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2022;28(18_Suppl):Abstract nr IA020.
Non-steroidal anti-inflammatory drugs (NSAIDs) in cancer pain: A database analysis to determine recruitment feasibility for a clinical trial
Authors: Page Andrew J , Spencer Katie , Mulvey Matthew R , Laird Barry JA , Bennett Michael I 
Published: September 2022

Background: Insufficient evidence exists to support or refute use of NSAIDs for managing cancer pain. Palliative physicians support a placebo-controlled trial of NSAIDs as strong opioid adjuncts for cancer-induced bone pain as the most pragmatic design to benefit clinical practice. Aim: We aimed to determine patient numbers receiving palliative radiotherapy for cancer-induced bone pain, estimate the suitability of NSAID prescription and determine survival, guiding future trial feasibility. Design: A retrospective observational database analysis was undertaken using 5 years of routinely collected regional radiotherapy and healthcare data, filtered to achieve a cohort with cancer-induced bone pain. Demographics and survival were linked to available serology and co-morbidity data. Setting/participants: Data was sourced from the regional Leeds Cancer Centre, a tertiary care setting. Patients who underwent palliative single fraction 8 gray (Gy) radiotherapy treatment for cancer-induced bone pain were included, totalling 2411 over 5 years. Results: A mean of 478 patients received palliative radiotherapy for cancer-induced bone pain annually. Median age (IQR) was 70 (62–77); negatively skewed (−0.69). 65.3% died within 1 year of radiotherapy; 48.0% within 6 months. Age was not associated with survival on univariable analysis (HR 0.999 (95% CI 0.996–1.003)). Serology from 1063 patients (44.2%) were available; eGFR was ⩾60 mL/min/1.73 m2 in 83.0%. From available data (1352 pts; 51.6% of sample), 20.2% had a coded co-morbidity contra-indicating NSAIDs. Combining serology and co-morbidities, 68.5% could be considered for NSAID prescription. Conclusions: Patient numbers at a regional radiotherapy centre support the feasibility of trial recruitment. Available serology and co-morbidity data suggest two-thirds may be suitable for NSAID prescription.
Strategies for recruiting the dependent children of patients with a life-limiting illness as research participants
Authors: Marshall Steve , Stephenson Pam , Sheehan Denice 
Published: September 2022

Background: The voices of children and adolescents have historically been substituted by the perspective of adults. There is growing recognition that children (<18 years old) are able to participate in research and appreciate the opportunity to participate in studies. Aim: To share the strategies employed by two research teams from USA and UK, who have successfully recruited children living with parental life-limiting illness as research participants. Findings: The researchers overcame common challenges when negotiating ethics committees by anticipating the IRB/REC concerns, providing the committees with detailed applications including distress protocols, and offering resources to their ethics committee to learn about conducting research with this population. The researchers navigated recruitment and gatekeeping by clinicians and parents by partnering with clinical agencies and nurturing relationships with practitioners who are supportive of the research, offering to present the findings of the study with continuing education credits, and developing children’s, adolescents’ and parents’ project advisory groups to support recruitment, data collection and analysis. Conclusions: Simple strategies can be used to overcome barriers to recruitment, providing opportunities for children to be research participants and for their unique perspectives to be heard in palliative care research.
An updated analysis on the association of GSTM1 polymorphism and smoking exposure with the increased risk of coronary heart disease
Authors: Liu Min , Gu Ye , Ma Jian-Ning , Bao Ke-Na , Ao Li , Ni Xin 
Published: September 2022

Objective To undertake a meta-analysis to investigate if there is an association between the glutathione S-transferase mu 1 ( GSTM1) gene polymorphism, coronary artery disease (CAD) susceptibility and smoking. Methods Electronic databases, including PubMed®, Web of Science and Embase®, were searched for relevant case–control studies. Data were extracted and the odds ratio (OR) was calculated and appropriate statistical methods were used for the meta-analysis. Results The analysis included eight studies with a total of 1880 cases with CAD and 1758 control subjects. The results of this meta-analysis demonstrated that there is no association between the GSTM1 null and CAD (OR 1.24, 95% confidence interval [CI] 1.00, 1.55). An increased risk of CAD was observed in the smoking population with the GSTM1 null genotype (OR 1.48, 95% CI 1.02, 2.15). Subgroup analyses of geographical region, genotyping method and publication language category demonstrated potential relationships among gene polymorphism, smoking and CAD. Conclusions Based on the current literature, the GSTM1 null genotype was associated to CAD in the smoking population. The interaction between smoking and GSTM1 polymorphism may contribute to the susceptibility of CAD.
Impact on Blood Product Utilization with Thromboelastography Guided Resuscitation for Gastrointestinal Hemorrhage
Authors: Rizvi Ghazi , Marcinkowski Bridget , Srinivasa Nandan , Jett Alex , Benjenk Ivy , Davison Danielle , Yamane David 
Published: September 2022

Background Thromboelastography (TEG) can guide transfusion therapy in trauma and has been associated with decreased transfusion requirements. This population differs from the medical population where the most common bleeding source is gastrointestinal hemorrhage (GIB). The utility of TEG in patients with acute GIB is not well described. We sought to assess whether the use of TEG impacts blood product utilization in patients with medical GIB. Methods A retrospective study looking at all adult patients admitted with a primary diagnosis of GIB to the George Washington University Intensive Care Unit (ICU) between 01/01/2017 to 12/31/2019. The primary intervention was the use of TEG to guide blood product resuscitation in addition to standard of care (TEG arm) versus standard of care alone (non-TEG arm). Results The primary outcome was the total number of blood products utilized. Patients in the TEG arm used more blood products compared to the non-TEG arm (9.10 vs 3.60, p < 0.001). There was no difference in secondary endpoints except for an increased requirement for mechanical ventilation within the TEG arm (26.2% vs 13.4%, p  =  0.018). Conclusions The use of TEG to guide resuscitation in patients with acute GIB may be associated with increased blood product utilization without any clinical benefit to patient-centered outcomes.
Secondary syphilis with extra-genital condyloma lata: A case report and review of the literature
Authors: Barei Francesca , Murgia Giulia , Ramoni Stefano , Cusini Marco , Marzano Angelo V 
Published: September 2022

Background Syphilis is known as the “great imitator” because of its polymorphic clinical manifestations. Condyloma lata are an uncommon mucocutaneous manifestation of secondary syphilis, generally localized in intertriginous areas, such as the genitals and anus. Extragenital localization of condyloma lata is considered unusual. Methods A case study of extra-genital condylomata is presented. To contextualise the case, a literature review of extra-genital condylomata lata was subsequently undertaken. The authors searched MEDLINE/PubMed, Scopus and Excerpta Medica/EMBASE English-language sources using the following keywords: “condyloma lata”, “condylomata lata”, and “condyloma latum”. Results Thirty-five papers (from 1940 to 2021) describing an extra-anogenital localization of condyloma lata were found and are summarized in Table 1. Patients were mainly males (82.1%), with a mean age of 31.9 years. Most of them showed other manifestations of secondary syphilis (53.9%). In a minority of cases (39.0%), concomitant anogenital condyloma lata were present, thus making the diagnosis easier. The toe web localization was the most documented (26.2%) followed by the oral cavity (23.8%). Conclusion In the presence of extra-genital condyloma lata, the differential diagnosis is not always clear, especially when no other muco-cutaneous lesions are observed. In the case of eroded or wet lesions involving any cutaneous fold, associated or not with other cutaneous manifestations, a sexual history should be obtained, and syphilis must be considered.
Latrine Utilization and Associated Factors in Transformed District, West Gojjam Zone, Amhara Region, Ethiopia, 2021
Authors: Degu Abrham , Girma Meskerem , Melese Amsalu Birara 
Published: September 2022

Background: Ethiopia has been encountering a higher predominance of communicable illnesses, which bring about high morbidity, mortality, and hospital admission rates. One of the higher contributing factors to this can be the lower level of latrine utilization. Objective: To assess latrine utilization and associated factors in transforming District, West Gojjam zone, Ethiopia. Methods: A community-based cross-sectional study was conducted from March to April 2021 among 352 households in the Dega Damot District, one of the transformed districts in the West Gojjam Zone. A systematic random sampling technique was used to select the study household. The data were collected through a face-to-face interview and right-away observation methods using structured questionnaires and an observational checklist respectively. Data were entered using Epi info version 7 and exported to a statistical package for social science’s version 25. Independent variables that had a P-value of <.25 were included in the multivariable binary logistic regression model. Variables with P-values of less than .05 were declared as statistically significant and an odds ratio of 95% CI was used to measure the strength of association between outcome and predictor variables. Results: We found that the prevalence of latrine utilization among households was 48.9% (95% CI: 44, 54). The household head has good knowledge of latrine utilization (AOR = 2.96, 95% CI 1.79, 4.87), a mother has formal education (AOR = 1.85, 95% CI 1.13, 3.04), daily cleaning of the latrine (AOR = 1.99, 95% CI 1.06, 3.74), and latrine having squat hole cover (AOR = 8.08, 95% CI 3.13, 20.87) were factors significantly associated with latrine utilization. Conclusion: In the transformed district latrine utilization was low Knowledge, education status, latrine cleaning frequency, and squat hole cover were factors associated with latrine utilization. Market-based sanitation, health extension program, and behavioral change communication strategies need to be strengthened to improve sustainable and consistent use of latrines.
Extensor hood injuries in elite boxers: injury characteristics, surgical technique and outcomes
Authors: Matharu Gulraj S. , Gatt Ian T. , Delaney Rachel , Loosemore Michael , Hayton Michael J. 
Published: September 2022

We describe our experience of managing extensor hood injuries in boxers (57 fingers). The diagnosis was mostly clinical, with imaging only if the diagnosis was equivocal. The middle (61%) and index (26%) digits were most frequently injured. On exploration, 26% had no hood tear, however all required tenolysis from the adherent capsule. Of 42 hood tears, 15 were central splits between adjacent extensor tendons in the index or little fingers,15 tears were on the ulna side of the extensor tendon and 12 tears were on the radial side. A pseudobursa was encountered in 35%, capsular tears in 28% and chondral injury in one patient. Longitudinal curved metacarpophalangeal joint incisions were used, with hood repair performed in flexion using a locked running suture. Mean postoperative metacarpophalangeal joint flexion was 90°. Ninety-eight per cent returned to the same level of boxing at a mean of 8 months (range 1–24) from surgery. One finger was revised for re-rupture 6 months later. A reproducible technique for treating these injuries is described, with patients able to return to boxing with little risk of complications. Level of evidence: IV
Advancement of door-to-needle times in acute stroke treatment after repetitive process analysis: never give up!
Authors: Ernst Johanna , Storch Kai F. , Tran Anh Thu , Gabriel Maria M. , Leotescu Andrei , Boeck Anna-Lena , Huber Meret K. , Abu-Fares Omar , Bronzlik Paul , Götz Friedrich , Worthmann Hans , Schuppner Ramona , Grosse Gerrit M. , Weissenborn Karin 
Published: September 2022

Background: In acute ischemic stroke, timely treatment is of utmost relevance. Identification of delaying factors and knowledge about challenges concerning hospital structures are crucial for continuous improvement of process times in stroke care. Objective: In this study, we report on our experience in optimizing the door-to-needle time (DNT) at our tertiary care center by continuous quality improvement. Methods: Five hundred forty patients with acute ischemic stroke receiving intravenous thrombolysis (IVT) at Hannover Medical School were consecutively analyzed in two phases. In study phase I, including 292 patients, process times and delaying factors were collected prospectively from May 2015 until September 2017. In study phase II, process times of 248 patients were obtained from January 2019 until February 2021. In each study phase, a new clinical standard operation procedure (SOP) was implemented, considering previously identified delaying factors. Pre- and post-SOP treatment times and delaying factors were analyzed to evaluate the new protocols. Results: In study phase I, SOP I reduced the median DNT by 15 min. The probability to receive treatment within 30 min after admission increased by factor 5.35 [95% confidence interval (CI): 2.46–11.66]. Further development of the SOP with implementation of a mobile thrombolysis kit led to a further decrease of DNT by 5 min in median in study phase II. The median DNT was 29 (25th–75th percentiles: 18–44) min, and the probability to undergo IVT within 15 min after admission increased by factor 4.2 (95% CI: 1.63–10.83) compared with study phase I. Conclusion: Continuous process analysis and subsequent development of targeted workflow adjustments led to a substantial improvement of DNT. These results illustrate that with appropriate vigilance, there is constantly an opportunity for improvement in stroke care.
Nosocomial COVID-19, a risk illustrated by the first in-hospital transmission of B.1.1.7 variant of SARS-CoV-2 in a French University Hospital
Authors: Legeay Clément , Lefeuvre Caroline 
Published: September 2022

Objectives In this short report, we describe the first nosocomial spread of B.1.1.7 variant (GR/20I/501Y.V1) in a French hospital, underlining the different aspects of in-hospital transmission of SARS-CoV-2. Patients and methods Retrospective study of a SARS-CoV-2 cluster investigation in January 2021. All cases were screened with RT-PCR. Results First transmission occurred in a double room with a COVID-19 imported cases, undetected upon admission. Healthcare workers, their relatives and patients’ relatives were screened. Eleven secondary cases were identified within a week, in and out of the hospital (in hospital attack rate: 3.1%). No severe COVID-19 was encountered. Conclusions This report highlights several in-hospital chains of transmission involved with COVID-19 with rapid spread.