bluuebunny/crossref_metadata_2025_split huggingface dataset:
DEPDC1B Promotes Melanoma Angiogenesis and Metastasis through Sequestration of Ubiquitin Ligase CDC16 to Stabilize Secreted SCUBE3
Authors: Hu Feng , Fong Ki On , Cheung May Pui Lai , Liu Jessica Aijia , Liang Rui , Li Tsz Wai , Sharma Rakesh , IP Philip Pun‐Ching , Yang Xintao , Cheung Martin 
Published: January 2022

AbstractThe ability of melanoma to acquire metastasis through the induction of angiogenesis is one of the major causes of skin cancer death. Here, it is found that high transcript levels of DEP domain containing 1B (DEPDC1B) in cutaneous melanomas are significantly associated with a poor prognosis. Tissue microarray analysis indicates that DEPDC1B expression is positively correlated with SOX10 in the different stages of melanoma. Consistently, DEPDC1B is both required and sufficient for melanoma growth, metastasis, angiogenesis, and functions as a direct downstream target of SOX10 to partly mediate its oncogenic activity. In contrast to other tumor types, the DEPDC1B‐mediated enhancement of melanoma metastatic potential is not dependent on the activities of RHO GTPase signaling and canonical Wnt signaling, but is acquired through secretion of signal peptide, CUB domain and EGF like domain containing 3 (SCUBE3), which is crucial for promoting angiogenesis in vitro and in vivo. Mechanistically, DEPDC1B regulates SCUBE3 protein stability through the competitive association with ubiquitin ligase cell division cycle 16 (CDC16) to prevent SCUBE3 from undergoing degradation via the ubiquitin‐proteasome pathway. Importantly, expression of SOX10, DEPDC1B, and SCUBE3 are positively correlated with microvessel density in the advanced stage of melanomas. In conclusion, it is revealed that a SOX10‐DEPDC1B‐SCUBE3 regulatory axis promotes melanoma angiogenesis and metastasis, which suggests that targeting secreted SCUBE3 can be a therapeutic strategy against metastatic melanoma.
Nanophysical Antimicrobial Strategies: A Rational Deployment of Nanomaterials and Physical Stimulations in Combating Bacterial Infections
Authors: Jia Bingqing , Du Xuancheng , Wang Weijie , Qu Yuanyuan , Liu Xiangdong , Zhao Mingwen , Li Weifeng , Li Yong‐Qiang 
Published: January 2022

AbstractThe emergence of bacterial resistance due to the evolution of microbes under antibiotic selection pressure, and their ability to form biofilm, has necessitated the development of alternative antimicrobial therapeutics. Physical stimulation, as a powerful antimicrobial method to disrupt microbial structure, has been widely used in food and industrial sterilization. With advances in nanotechnology, nanophysical antimicrobial strategies (NPAS) have provided unprecedented opportunities to treat antibiotic‐resistant infections, via a combination of nanomaterials and physical stimulations. In this review, NPAS are categorized according to the modes of their physical stimulation, which include mechanical, optical, magnetic, acoustic, and electrical signals. The biomedical applications of NPAS in combating bacterial infections are systematically introduced, with a focus on their design and antimicrobial mechanisms. Current challenges and further perspectives of NPAS in the clinical treatment of bacterial infections are also summarized and discussed to highlight their potential use in clinical settings. The authors hope that this review will attract more researchers to further advance the promising field of NPAS, and provide new insights for designing powerful strategies to combat bacterial resistance.
Dual‐Ion Flux Management for Stable High Areal Capacity Lithium–Sulfur Batteries
Authors: Liu Borui , Torres Juan F. , Taheri Mahdiar , Xiong Pan , Lu Teng , Zhu Junwu , Liu Yun , Yu Guihua , Tricoli Antonio 
Published: January 2022

AbstractControlling the interaction between multiple ion fluxes is a major challenge that hampers the adoption of post‐Li intercalation battery systems, which offer a multifold increase in energy density over existing technologies. Here, a dual‐ion flux management strategy is introduced to simultaneously control the distribution of Li and polysulfide ions in high‐energy Li–S batteries. This approach enables long‐term use of high S‐loading cathodes with 13.6 mgsulfur cm−2, achieving 9 mAh cm−2 areal capacity with 73% capacity retention for 1000 charging/discharging cycles. The battery system relies on the use of a multiscale membrane, with comparable size to existing battery separators, which simultaneously acts as an atomic redisperser for Li ions, dielectric and mechanical separator, polysulfide barrier, and extended cathode. Combined characterization and modeling reveal that the membrane is stable down to <1.0 V versus Li+/Li and result in a uniform Li‐ion flux to the anode and effective polysulfide confinement and reutilization. The potential of this approach for application is demonstrated by the fabrication of stable pouch cells with a horizontal surface of 40 cm2 and 6.8 mAh cm−2 capacity. These findings provide an exemplification of the potential for effective multi‐ion flux management for future energy storage and emerging electrochemical systems.
Non‐Volatile Perfluorophenyl‐Based Additive for Enhanced Efficiency and Thermal Stability of Nonfullerene Organic Solar Cells via Supramolecular Fluorinated Interactions
Authors: Hung Kai‐En , Lin Yu‐Sheng , Xue Yung‐Jing , Yang Hau‐Ren , Lai Yu‐Ying , Chang Je‐Wei , Su Chun‐Jen , Su An‐Chung , Hsu Chain‐Shu , Jeng U‐Ser , Cheng Yen‐Ju 
Published: January 2022

AbstractA novel non‐volatile additive, fluorinated bis(perfluorophenyl)pimelate (BF7), is demonstrated to effectively improve both the efficiency and thermal stability of a highly efficient organic solar cell (OSC), comprising fluorinated Y6 as the small‐molecule acceptor and PM6 as the polymer donor. Processed with optimized 0.5 wt% BF7 in solution, the PM6:Y6:BF7 device achieves an elevated power conversion efficiency (PCE) of 17.01%, compared to 15.16% of that processed without BF7. Moreover, the BF7‐elevated PCE can sustain 95% of the best PCE over 100 °C annealing for 72 h. Grazing incidence X‐ray scattering and differential scanning calorimetry results consistently indicate that BF7 in the PM6:Y6:BF7 device interacts preferentially with Y6, resulting in improved fractal‐like network structures of the active layer with optimized size and orientation of Y6 nano‐crystallites and elevated thermal stability. Molecular simulation also supports that the observed structure and thermal stability is associated with the F–π noncovalent supramolecular interactions between the perfluorophenyl moieties of BF7 and difluorophenyl‐based FIC‐end‐groups of Y6. Similar bifunctional BF7 effects are also observed in the well‐known PM6:IT‐4F system, suggesting that adding BF7 for concomitantly improved PCE and thermal stability might extend generally to OSCs that feature small molecule acceptors of difluorophenyl end‐groups.
Using truck‐to‐trunk programs to increase food security and help support farm incomes
Authors: Dorfman Jeffrey H. , Grant Jared D. , Worley Julian M. 
Published: January 2022

AbstractThe initial lockdown phase of the coronavirus pandemic in the U.S. simultaneously caused food demand from the food service industry to plummet and food insecurity to soar. This created a unique scenario with a large need for food access and a large surplus of food, but no established way to connect the two. The Georgia Department of Agriculture worked with agricultural producers, distributors, and local governments to create a program that facilitated the sale of excess farm commodities and helped alleviate food insecurity. This paper describes how the program was designed and the lessons learned in its execution.
Health‐related quality of life in patients with relapsed/refractory multiple myeloma treated with pomalidomide and dexamethasone ± subcutaneous daratumumab: Patient‐reported outcomes from the APOLLO trial
Authors: Terpos Evangelos , Dimopoulos Meletios A. , Boccadoro Mario , Delimpasi Sosana , Beksac Meral , Katodritou Eirini , Moreau Philippe , Pompa Alessandra , Symeonidis Argiris , Bila Jelena , Oriol Albert , Mateos Maria‐Victoria , Einsele Hermann , Orfanidis Ioannis , Gries Katharine S. , Fastenau John , Liu Kevin , He Jianming , Kampfenkel Tobias , Qiu Yanping , Amin Himal , Carson Robin , Sonneveld Pieter 
Published: January 2022

AbstractIn the phase 3 APOLLO trial, daratumumab in combination with pomalidomide and dexamethasone (D‐Pd) significantly reduced the rate of disease progression or death by 37% relative to Pd alone in patients with relapsed/refractory multiple myeloma (RRMM) who had received ≥1 prior line of therapy including lenalidomide and a proteasome inhibitor. Here, we present patient‐reported outcomes (PROs) from APOLLO. Median treatment duration was 11.5 months with D‐Pd and 6.6 months with Pd. PRO compliance rates were high and similar in both groups. No changes from baseline were observed for EORTC QLQ‐C30 global health status scores in either group, while physical and emotional functioning, disease symptoms, and adverse effects of treatment remained at baseline levels with D‐Pd but worsened with Pd. Reductions (p < 0.05) in pain and fatigue were seen at several time points with D‐Pd versus Pd. Overall, these results suggest patients' health‐related quality of life remained stable when daratumumab was added to Pd, with several results favoring D‐Pd versus Pd. These findings complement the significant clinical improvements observed with D‐Pd and support its use in patients with RRMM.
Chronic neutrophilic leukemia: 2022 update on diagnosis, genomic landscape, prognosis, and management
Authors: Szuber Natasha , Elliott Michelle , Tefferi Ayalew 
Published: January 2022

AbstractDisease OverviewChronic neutrophilic leukemia (CNL) is a rare, often aggressive myeloproliferative neoplasm (MPN) defined by persistent mature neutrophilic leukocytosis, bone marrow granulocyte hyperplasia, and frequent hepatosplenomegaly. The 2013 seminal discovery of oncogenic driver mutations in colony‐stimulating factor 3 receptor (CSF3R) in the majority of patients with CNL not only established its molecular pathogenesis but provided a diagnostic biomarker and rationale for pharmacological targeting.DiagnosisIn 2016, the World Health Organization (WHO) recognized activating CSF3R mutations as a central diagnostic feature of CNL. Other criteria include leukocytosis of ≥25 × 109/L comprising >80% neutrophils with <10% circulating precursors and rare blasts, and absence of dysplasia or monocytosis, while not fulfilling criteria for other MPN.ManagementThere is currently no standard of care for management of CNL, due in large part to the rarity of disease and dearth of formal clinical trials. Most commonly used therapeutic agents include conventional oral chemotherapy (e.g., hydroxyurea), interferon, and Janus kinase (JAK) inhibitors, while hematopoietic stem cell transplant remains the only potentially curative modality.Disease UpdatesIncreasingly comprehensive genetic profiling in CNL, including new data on clonal evolution, has disclosed a complex genomic landscape with additional mutations and combinations thereof driving disease progression and drug resistance. Although accurate prognostic stratification and therapeutic decision‐making remain challenging in CNL, emerging data on molecular biomarkers and the addition of newer agents, such as JAK inhibitors, to the therapeutic arsenal, are paving the way toward greater standardization and improvement of patient care.
Identifizierung eines Zweifach‐Koordinierten Eisen(I)‐Oxalat‐Komplexes
Authors: Mayer Martin , Vankova Nina , Stolz Ferdinand , Abel Bernd , Heine Thomas , Asmis Knut R. 
Published: January 2022

AbstractExotische Oxidationszustände der Metalle der ersten Übergangsreihe haben in letzter Zeit großes Interesse geweckt. Um die Oxidationsstufen einer Reihe von Eisenoxalat‐Komplexen zu untersuchen, wurde eine wässrige Lösung von Eisen(III)‐nitrat und Oxalsäure mittels Flüssigstrahl‐Infrarot‐Laser‐Desorptions‐ und Elektrospray‐Massenspektrometrie untersucht. Wir zeigen, dass Eisen nicht nur in seinen üblichen Oxidationsstufen +II und +III, sondern auch in der ungewöhnlichen Oxidationsstufe +I nachgewiesen werden kann, sowohl im positiven als auch im negativen Ionenmodus. Die Gasphasenschwingungsspektren der anionischen Eisenoxalat‐Komplexe [FeIII(C2O4)2]−, [FeII(C2O4)CO2]− und [FeI(C2O4)]− werden mit Hilfe von Infrarot‐Photodissoziationsspektroskopie gemessen und ihre Strukturen durch Vergleich mit berechneten anharmonischen Schwingungsspektren auf der Grundlage der Störungstheorie zweiter Ordnung zugeordnet.
Design, Synthesis, and Targeted Delivery of an Immune Stimulant that Selectively Reactivates Exhausted CAR T Cells
Authors: Napoleon John Victor , Zhang Boning , Luo Qian , Srinivasarao Madduri , Low Philip S. 
Published: January 2022

AbstractAlthough chimeric antigen receptor (CAR) T cells have demonstrated significant promise in suppressing hematopoietic cancers, their applications in treating solid tumors have been limited by onset of CAR T cell exhaustion that accompanies continuous CAR T cell exposure to tumor antigen. To address this limitation, we have exploited the abilities of recently designed universal CARs to bind fluorescein and internalize a fluorescein‐TLR7 agonist conjugate by CAR‐mediated endocytosis. We demonstrate here that anti‐fluorescein CAR‐mediated uptake of a fluorescein‐TLR7‐3 conjugate can reactivate exhausted CAR T cells, leading to dramatic reduction in T cell exhaustion markers (PD‐1+Tim‐3+) and shrinkage of otherwise resistant tumors without inducing systemic activation of the immune system. We conclude that CAR T cell exhaustion can be reversed by administration of a CAR‐targeted TLR7 agonist, thereby enabling the CAR T cells to successfully treat solid tumors without incurring the systemic toxicity that commonly accompanies administration of nontargeted TLR7 agonists.
The water uptake, thermal and mechanical properties, and aging resistance to thermo‐oxidation of phenylboronic acid‐modified benzoxazine‐glass fiber composites
Authors: Hsu Chin‐shih , Hwang Po‐Yu 
Published: January 2022

AbstractPolybenzoxazines, also known as Benzoxazine (Bz) is one kind of high‐performance thermoset polymers. It manifests several advantages when used for thermal protection applications, such as thermal and dimensional stabilities, low rate of moisture absorption and near zero volatility in curing process. However, benzoxazine shows its drawbacks in terms of curing temperature, char yield at elevated temperature, and resin toughness. Thus, modification of Bz matrix would be essential in order to improve these unfavorable properties. In this study, a facile synthesis of phenylboronic acid‐modified (PBA) benzoxazine (PBz) and glass fibers (GF) composites with varied PBA ratios were prepared. Briefly, GF fabrics were impregnated with each of Bz or PBz/acetone solution and baked to form B‐staged prepregs. Then, the prepregs were stacked, molded and cured in a hot‐pressing machine to form composites. The present study shows the 10 wt% PBA modified‐Bz/GF composite is the optimal formulation as it exhibits minimal water uptake, enhanced char yield, decent thermomechanical stability in terms of glass transition temperature, exceptional interlaminar shear strength (ILSS) and highest flexural strength. Moreover, the PBz 10/GF composite subject to thermo‐oxidative aging still maintains good levels of shear and flexural properties for potential service as thermal protection layer.
Dispersion of hydroxyapatite nanoparticles in natural rubber latex and poly lactic acid based matrices
Authors: Cesar Mariana Biondi , Poli Hamish , Piazza Rodolfo Debone , Marques Rodrigo Fernando Costa , Herculano Rondinelli Donizetti , Grøndahl Lisbeth 
Published: January 2022

AbstractHydroxyapatite (HAp)‐polymer composite materials are of interest for materials that interface with or substitute bone tissue. HAp nanoparticles (length 290 nm, width 56 nm) synthesized by a wet chemical method were incorporated (5 wt%) into natural rubber latex (NRL), poly lactic acid (PLA) and NRL/PLA (75/25) solvent cast films using three different methods: dry nanoparticles; a dispersion prepared from dry nanoparticles; a dispersion prepared through solvent exchange. Common to all composite materials were an improvement in the contact angle by 10%–13% and a reduction in the elongation at break from 430% to 330%–370%. Furthermore, the method of HAp incorporation influenced the properties of the material with the use of dioxane suspension improving the homogeneity of the films as evidenced from visual appearance and SEM. This led to slower water uptake and higher thermal stability with a shift in the PLA melting peak from 296°C to 334°C when compared to pure polymer and composites with poorly dispersed particle.
Effect of acids and freeze–thaw on the durability of modified rubberized concrete with optimum rubber crumb content
Authors: Kumar Rahul , Dev Nirendra 
Published: January 2022

AbstractInvestigations of the effect of acids and freeze–thaw on pozzolanic cement‐based rubberized concrete after surface treatment of rubber crumbs are limited. Rubberized concrete's mechanical and durability properties (water absorption, acid attack resistance, and freeze–thaw attack resistance) are evaluated. Six rubber crumbs content (0%, 10%, 15%, 20%, 25%, and 30%) and particle size 0.6–2.36 mm are used to replace fine aggregate in concrete partially, and 15% replacement level of rubber crumb is found to be the optimum quantity in concrete. Structural analyses show that the specimens remain in the crystalline phase after being submerged in H2SO4 and HCl acid. When rubberized concrete is immersed in H2SO4 and HCl solution with equal concentrations and duration, specimens immersed in HCl solution have been found to have less surface erosion, less weight loss, and lower compressive strength loss. When the conventional concrete mix is immersed in H2SO4 and HCl solution, the losses in compressive strength are 74.56% and 30.34%, but in rubberized concrete, the losses are 60.01% and 24.22% only. No apparent microcracks and no spalling on the surfaces of the specimens are found up to 90 freeze–thaw cycles. Rubberized concrete's ultrasonic velocity decreases slightly up to 90 freeze–thaw cycles, but it still has good concrete quality.
Nacre‐inspired construction of soft–hard double network structure to prepare strong, tough, and water‐resistant soy protein adhesive
Authors: Xu Yantao , Han Yufei , Li Yue , Luo Jing , Li Jianzhang , Li Jingchao , Gao Qiang 
Published: January 2022

AbstractSoy protein (SPI) adhesives are non‐toxic and eco‐friendly that can potentially replace traditional formaldehyde‐based adhesives to ease toxic gas emissions. The development of strong and toughness SPI adhesive benefits its bonding stability but is challenging. In this study, inspired by nacre structure, a soft–hard double network structure was constructed in SPI adhesive. The triglycidylamine (TGA) cross‐linked protein served as the hard phase to provide cohesion. In addition, the self‐synthesizing epoxidized rubber (ER) as soft phase cross‐linked protein and enhanced the interfacial force between hard and soft phase to dissipate energy during fracture, which improved the toughness of adhesive. The results showed that: compared with original SPI adhesive, the residue rate of SPI/4%TGA/3%ER adhesive increased by 7.9%, and the moisture absorption rate decreased by 16.7%. The dry and wet shear strength of the plywood prepared by SPI/4%TGA/3%ER adhesive increased by 58.9% and 160.4% to 1.86 and 1.38 MPa, which was higher than commercial polyamide‐epichlorohydrin modified SPI adhesive. The elongation at break increased by 55.2%–45%, the fracture energy increased by 233% to 2.96 MJ/m2, and the cracks on the adhesive surface disappeared, indicating that the strength, toughness, and water resistance of the adhesive were significantly improved. In this research, a soft–hard double network structure is constructed in a bio‐based adhesive to obtain excellent performance, this eco‐friendly adhesive opens up a new way to replace harmful formaldehyde‐based adhesives.
Genetic monitoring of the declining European stony sea urchin Paracentrotus lividus from the central Bay of Biscay (Asturias, northwest Spain) and attempts to restore its wild populations
Authors: Parrondo Marina , López Samuel , de la Uz Silvia , Rodríguez Carmen , Carrasco José F. , García‐Flórez Lucía , Borrell Yaisel J. 
Published: January 2022

Abstract

Paracentrotus lividus is a sea urchin with an important ecological role in the Cantabrian Sea ecosystem, where its populations are in severe decline and the regional government has implemented a population restoration strategy with the aim of preserving this valuable marine resource.
In this study, genetic monitoring was conducted for the first time in the central area of the southern Bay of Biscay to describe the genetic diversity patterns of P. lividus and to assess the potential impacts of conservation and mitigation actions on the wild gene pool. Genetic analyses were performed using the mitochondrial cytochrome b gene and microsatellite loci.
Asturian localities showed significant genetic heterogeneity, possibly due to genetic drift, and seemed to constitute a differentiated management unit with regard to other areas of the species’ distribution. The genetic diversity analyses comparing wild samples with those subjected to restoration experiments did not show significant negative effects on restored localities.
Sea urchins from hatcheries represented 3.5% of the total recaptured individuals (95% accuracy). Even when low hatchery contributions were detected in this work, the results pointed to the necessity of improving the initial autochthonous breeder genetic pool and the aquaculture strategies applied when restoring wild populations to avoid future unwanted negative effects on wild gene pools.
Understanding the preterm human heart: What do we know so far?
Authors: Schuermans Art , Lewandowski Adam J. 
Published: January 2022

AbstractGlobally, preterm birth affects more than one in every 10 live births. Although the short‐term cardiopulmonary complications of prematurity are well known, long‐term health effects are only now becoming apparent. Indeed, preterm birth has been associated with elevated cardiovascular morbidity and mortality in adulthood. Experimental animal models and observational human studies point toward changes in heart morphology and function from birth to adulthood in people born preterm that may contribute to known long‐term risks. Moreover, recent data support the notion of a heterogeneous cardiac phenotype of prematurity, which is likely driven by various maternal, early, and late life factors. This review aims to describe the early fetal‐to‐neonatal transition in preterm birth, the different structural and functional changes of the preterm human heart across developmental stages, as well as potential factors contributing to the cardiac phenotype of prematurity.