bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying Determinants of Neuro-Enchancement Substance Use in	Students
Authors: Galli Federica , Chirico Andrea , Mallia Luca , Alivernini Fabio , Manganelli Sara , Zelli Arnaldo , Hagger Martin S. , Lucidi Fabio 
Published: July 2022

Abstract. Background: Use of Neuro-Enhancement Substances (NES) such as prescription drugs, illicit drugs, or alcohol to improve cognition, prosocial behavior, and performance is increasing among students. Aims: The study applied a multi-theory, integrated theoretical model to identify motivational and social cognition determinants of NES use among students. Methods: A prospective longitudinal design was adopted with 306 high school (66.8% female; Mage = 17.31 years, SD = 0.93) and 692 university (70.5% female; Mage = 24.97 years, SD = 6.64) students. They completed measures of motivation, social cognition constructs, and planning with respect to studying behavior and NES use. Results: Well-fitting structural equation models indicated the pervasive influence of autonomous motivation, attitudes, subjective norms, and perceived behavioral control for studying, as well as of attitudes, subjective norms, and perceived behavioral control for NES use. Inclusion of past NES use increased explained variance in NES use and attenuated model effects, but the pattern of effects remained. Multi-group analyses indicated consistency in the pattern model effects across high school and university students. Limitations: The study findings might not be generalizable, as student samples were not randomly recruited. Furthermore, NES use only relied on self-report, and its assessment did not consider different NES substances. Finally, there was no assessment of implicit attitudes and habits toward studying and NES use. Conclusions: Findings extend prior literature by demonstrating the integrated guiding view that students’ motivation and beliefs about studying influence their beliefs about and use of NES. Furthermore, the findings provide starting points for interventions targeting the reduction in NES use.
Net Primary Production and Ecosystem Carbon Flux of Brazilian Tropical Savanna Ecosystems From Eddy Covariance and Inventory Methods
Authors: Vourlitis George L. , Pinto Osvaldo Borges , Dalmagro Higo J. , Enrique Zanella de Arruda Paulo , de Almeida Lobo Francisco , de Souza Nogueira José 
Published: July 2022

AbstractEstimates of net primary (NPP) and ecosystem production (NEP) are needed for tropical savanna, which is structurally diverse but understudied compared to tropical rainforest. We used eddy covariance and inventory methods to estimate carbon (C) fluxes for an upland mixed grassland and a seasonally flooded forest to determine the correspondence between these methods and assess the contribution of C cycling components to the total NPP. Both techniques provided similar estimates of net ecosystem CO2 exchange (−3.0 ‒ 2.3 MgC ha−1 y−1 for eddy covariance vs. −2.0 ‒ 4.3 MgC ha−1 y−1 for inventory), gross primary production (7.5–16.3 MgC ha−1 y−1 for eddy covariance vs. 8.7–18.4 MgC ha−1 y−1 for inventory), and total NPP (0.9–7.5 MgC ha−1 y−1 for eddy covariance vs. 2.0–9.5 MgC ha−1 y−1 for inventory). Belowground NPP accounted for 49%–53% of the total NPP for both ecosystems, followed by aboveground litter (26%–27%) and wood (16%–17%) production. Increases in water availability increased the potential for C storage, but the mechanism was different in the savanna types. Compared to other savanna ecosystems, the mixed grassland had a lower productivity and C use efficiency (CUE = NPP/GPP = 0.28), while the Cerrado forest had a high CUE (0.58) and similar C flux rates to other tropical savanna forests. The agreement in the C cycle estimates derived from the eddy covariance and inventory methods increases our confidence in the productivity estimates for these tropical savanna ecosystems.
Imaging the Whole‐Lithosphere Architecture of a Mineral System—Geophysical Signatures of the Sources and Pathways of Ore‐Forming Fluids
Authors: Comeau Matthew J. , Becken Michael , Kuvshinov Alexey V. 
Published: July 2022

AbstractMineral systems can be thought of as a combination of several critical elements, including the whole‐lithosphere architecture, favorable geodynamic/tectonic events, and fertility. Because they are driven by processes across various scales, exploration benefits from a scale‐integrated approach. There are open questions regarding the source of ore‐forming fluids, the depth of genesis, and their transportation through the upper crust to discrete emplacement locations. In this study, we investigate an Au–Cu metal belt located at the margin of an Archean‐Paleoproterozoic microcontinent. We explore the geophysical signatures by analyzing three‐dimensional models of the electrical resistivity and shear‐wave velocity throughout the lithosphere. Directly beneath the metal belt, narrow, vertical, finger‐like low‐resistivity features are imaged within the resistive upper‐middle crust and are connected to a large low‐resistivity zone in the lower crust. A broad low‐resistivity zone is imaged in the lithospheric mantle, which is well aligned with a zone of low shear‐wave velocity, examined with a correlation analysis. In the upper‐middle crust, the resistivity signatures give evidence for ancient pathways of fluids, constrained by a structure along a tectonic boundary. In the lower lithosphere, the resistivity and velocity signatures are interpreted to represent a fossil fluid source region. We propose that these signatures were caused by a combination of factors related to refertilization and metasomatism of the lithospheric mantle by long‐lived subduction at the craton margin, possibly including iron enrichment, F‐rich phlogopite, and metallic sulfides. The whole‐lithosphere architecture controls the genesis, evolution, and transport of ore‐forming fluids and thus the development of the mineral system.
Transient Brittle Creep Mechanism Explains Early Postseismic Phase of the 2011 Tohoku‐Oki Megathrust Earthquake: Observations by High‐Rate GPS Solutions
Authors: Periollat Axel , Radiguet Mathilde , Weiss Jérôme , Twardzik Cédric , Amitrano David , Cotte Nathalie , Marill Lou , Socquet Anne 
Published: July 2022

AbstractThe early stage of the postseismic phase is characterized by a large deformation rate. Its analysis is thus key to decipher the role played by different mechanisms (afterslip and viscoelasticity) at various time scales. Here, we process GPS data to obtain 30‐s kinematic position time series recording the surface deformation following the Mw 9.0 Tohoku‐Oki megathrust earthquake (2011), and combine them with static solutions over 9 years. We analyze the temporal evolution of the time series and use these observations to image the postseismic slip. We find that the first month of deformation following Tohoku‐Oki can be explained by an afterslip mechanism, that exhibits an “Omori‐like” decay, with a p‐value around 0.75 almost everywhere with the exception of a small region around Ibaraki prefecture where p ∼ 1 is observed. This p < 1 indicates that the postseismic displacements do not increase logarithmically with time as predicted by rate‐and‐state rheology. Instead, we argue that early afterslip is associated with a transient brittle creep mechanism. We use numerical simulations to show that an exponent of p < 1 can be explained by a combination of thermal activation of local slips and elastic interactions. Over longer time scales, an additional mechanism is required to explain the observed deformation signal, and the transient brittle creep mechanism is combined with viscoelastic relaxation modeled by a Newtonian flow. The spatial analysis reveals two distinct afterslip regions, a major one on the North, associated with a p‐value around 0.75, and a smaller one close to the Ibaraki aftershock, associated with p ∼ 1.
Greenland Ice Core Record of Last Glacial Dust Sources and Atmospheric Circulation
Authors: Újvári G. , Klötzli U. , Stevens T. , Svensson A. , Ludwig P. , Vennemann T. , Gier S. , Horschinegg M. , Palcsu L. , Hippler D. , Kovács J. , Di Biagio C. , Formenti P. 
Published: July 2022

AbstractAbrupt and large‐scale climate changes have occurred repeatedly and within decades during the last glaciation. These events, where dramatic warming occurs over decades, are well represented in both Greenland ice core mineral dust and temperature records, suggesting a causal link. However, the feedbacks between atmospheric dust and climate change during these Dansgaard–Oeschger events are poorly known and the processes driving changes in atmospheric dust emission and transport remain elusive. Constraining dust provenance is key to resolving these gaps. Here, we present a multi‐technique analysis of Greenland dust provenance using novel and established, source diagnostic isotopic tracers as well as results from a regional climate model including dust cycle simulations. We show that the existing dominant model for the provenance of Greenland dust as sourced from combined East Asian dust and Pacific volcanics is not supported. Rather, our clay mineralogical and Hf–Sr–Nd and D/H isotopic analyses from last glacial Greenland dust and an extensive range of Northern Hemisphere potential dust sources reveal three most likely scenarios (in order of probability): direct dust sourcing from the Taklimakan Desert in western China, direct sourcing from European glacial sources, or a mix of dust originating from Europe and North Africa. Furthermore, our regional climate modeling demonstrates the plausibility of European or mixed European/North African sources for the first time. We suggest that the origin of dust to Greenland is potentially more complex than previously recognized, demonstrating more uncertainty in our understanding dust climate feedbacks during abrupt events than previously understood.
Monocytic myeloid-derived suppressive cells mitigate over-adipogenesis of bone marrow microenvironment in aplastic anemia by inhibiting CD8+ T cells
Authors: Qu Ying , Sun Zhengxu , Yuan Yan , Li Zifeng , Wang Fen , Wu Kunpeng , Yu Huihui , Lin Qiwang , Fei He , Chen Jian , Qian Maoxiang , Cheng Yunfeng , Jiang Hua , Chen Tong 
Published: July 2022

AbstractAplastic anemia (AA) is a blood disorder resulted from over-activated T-cell related hematopoietic failure, with the characterization of hypocellularity and enhanced adipogenic differentiation of mesenchymal stroma cells (MSCs) in bone marrow (BM). However, little is known about the relationship between immune imbalance and polarized adipogenic abnormity of BM microenvironment in this disease entity. In the present study, we differentiated BM-MSCs into osteoblastic or adipogenic lineages to mimic the osteo-adipogenic differentiation. Activated CD8+ T cells and interferon-γ (IFN-γ) were found to stimulate adipogenesis of BM-MSCs either in vitro or in vivo of AA mouse model. Interestingly, myeloid-derived suppressive cells (MDSCs), one of the immune-regulating populations, were decreased within BM of AA mice. We found that it was not CD11b+Ly6G+Ly6C- granulocytic-MDSCs (gMDSCs) but CD11b+Ly6G-Ly6C+ monocytic-MDSCs (mMDSCs) inhibiting both T cell proliferation and IFN-γ production via inducible nitric oxide synthetase (iNOS) pathway. Single-cell RNA-sequencing (scRNA-seq) of AA- and mMDSCs-treated murine BM cells revealed that mMDSCs transfusion could reconstitute BM hematopoietic progenitors by inhibiting T cells population and signature cytokines and decreasing immature Adipo-Cxcl12-abundant reticular cells within BM. Multi-injection of mMDSCs into AA mice reduced intra-BM T cells infiltration and suppressed BM adipogenesis, which subsequently restored the intra-BM immune balance and eventually prevented pancytopenia and hypo-hematopoiesis. In conclusion, adoptive transfusion of mMDSCs might be a novel immune-regulating strategy to treat AA, accounting for not only restoring the intra-BM immune balance but also improving stroma’s multi-differentiating microenvironment.
Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model
Authors: Han Xiaobo , de Dieu Habimana Jean , Li Amy L. , Huang Rongqi , Mukama Omar , Deng Weiyue , Wang Ling , Zhang Yuying , Wang Wei , Deng Sihao , Peng Kexin , Ni Bin , Zhang Shusheng , Huang Jufang , Yan Xiao-xin , Li Zhiyuan 
Published: July 2022

AbstractDefects in ataxin-3 proteins and CAG repeat expansions in its coding gene ATXN3 cause Spinocerebellar Ataxia Type 3 (SCA3) or Machado-Joseph disease (MJD) polyglutamine neurodegenerative disease. The mutant proteins aggregate as inclusion bodies in cells and compete with wild-type ataxin-3, which leads to neuronal dysfunction or death and impairs Beclin1-mediated autophagy. It has been reported that Mesenchymal stem cells (MSCs) can reliably treat several neurodegenerative diseases. Herein, we used a Transcription Factor EB (TFEB) nuclear translocation-mediated MSCs co-culture approach to reconstitute autophagy and lysosomal biogenesis, and reduce SCA3-like behaviors in induced pluripotent stem cells (iPSCs)-derived neuron cells models. Our iPSCs model showed enhanced expression of autophagy proteins, attenuated the expression and toxic effects of mutant ataxin-3 on neurons, and alleviated the effects of ataxin-3 on autophagy. Therefore, MSCs are associated with autophagy-inducing therapy and compared to animal models, our MSCs co-culture could be used as a novel and potential therapeutic approach to study SCA3 disease and other neurodegenerative diseases.
Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression
Authors: Wall Mark J. , Hill Emily , Huckstepp Robert , Barkan Kerry , Deganutti Giuseppe , Leuenberger Michele , Preti Barbara , Winfield Ian , Carvalho Sabrina , Suchankova Anna , Wei Haifeng , Safitri Dewi , Huang Xianglin , Imlach Wendy , La Mache Circe , Dean Eve , Hume Cherise , Hayward Stephanie , Oliver Jess , Zhao Fei-Yue , Spanswick David , Reynolds Christopher A. , Lochner Martin , Ladds Graham , Frenguelli Bruno G. 
Published: July 2022

AbstractThe development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity of GPCRs to couple to multiple intracellular signalling pathways. This promiscuous coupling leads to numerous downstream cellular effects, some of which are therapeutically undesirable. This is especially the case for adenosine A1 receptors (A1Rs) whose clinical potential is undermined by the sedation and cardiorespiratory depression caused by conventional agonists. We have discovered that the A1R-selective agonist, benzyloxy-cyclopentyladenosine (BnOCPA), is a potent and powerful analgesic but does not cause sedation, bradycardia, hypotension or respiratory depression. This unprecedented discrimination between native A1Rs arises from BnOCPA’s unique and exquisitely selective activation of Gob among the six Gαi/o subtypes, and in the absence of β-arrestin recruitment. BnOCPA thus demonstrates a highly-specific Gα-selective activation of the native A1R, sheds new light on GPCR signalling, and reveals new possibilities for the development of novel therapeutics based on the far-reaching concept of selective Gα agonism.
Duration of protection of CoronaVac plus heterologous BNT162b2 booster in the Omicron period in Brazil
Authors: Cerqueira-Silva Thiago , de Araujo Oliveira Vinicius , Paixão Enny S. , Júnior Juracy Bertoldo , Penna Gerson O. , Werneck Guilherme L. , Pearce Neil , Barreto Maurício L. , Boaventura Viviane S. , Barral-Netto Manoel 
Published: July 2022

AbstractTo date, no information has been published on the effectiveness of inactivated whole-virus COVID-19 vaccines plus heterologous booster against symptomatic infection and severe outcomes (hospitalization or death) during the dominance of the SARS-CoV-2 Omicron variant period. We evaluated the vaccine effectiveness (VE) of CoronaVac plus BNT162b2 booster during the period of dominance of the Omicron variant in Brazil (January to April 2022). Using a test-negative design, we analysed data for 2,471,576 individuals tested during the Omicron variant’s dominant period using a nationally linked database from Brazil. Compared to unvaccinated, vaccinees maintained protection against severe outcomes, with an estimated VE of 84.1% (95% CI:83.2–84.9) at more than 120 days after BNT162b2 booster. Furthermore, while we detected a high level of protection against severe outcomes for individuals up to 79 years old, waning was observed for individuals aged ≥80 years, with VE decreasing from 81.3% (95% CI:77.9–84.2) at 31–60 days to 72.9% (95% CI:70.6–75.1) at 120 days or more after the booster dose. However, no significant protection against symptomatic infection was observed at this time period. In conclusion, except for individuals aged ≥80 years, CoronaVac plus a BNT162b2 booster dose offered high and durable protection against severe outcomes due to Omicron.
Bioinspired asymmetric amphiphilic surface for triboelectric enhanced efficient water harvesting
Authors: Zhang Song , Chi Mingchao , Mo Jilong , Liu Tao , Liu Yanhua , Fu Qiu , Wang Jinlong , Luo Bin , Qin Ying , Wang Shuangfei , Nie Shuangxi 
Published: July 2022

AbstractThe effective acquisition of clean water from atmospheric water offers a potential sustainable solution for increasing global water and energy shortages. In this study, an asymmetric amphiphilic surface incorporating self-driven triboelectric adsorption was developed to obtain clean water from the atmosphere. Inspired by cactus spines and beetle elytra, the asymmetric amphiphilic surface was constructed by synthesizing amphiphilic cellulose ester coatings followed by coating on laser-engraved spines of fluorinated ethylene propylene. Notably, the spontaneous interfacial triboelectric charge between the droplet and the collector was exploited for electrostatic adsorption. Additionally, the droplet triboelectric nanogenerator converts the mechanical energy generated by droplets falling into electrical energy through the volume effect, achieving an excellent output performance, and further enhancing the electrostatic adsorption by means of external charges, which achieved a water harvesting efficiency of 93.18 kg/m2h. This strategy provides insights for the design of water harvesting system.
Synergistic strain engineering of perovskite single crystals for highly stable and sensitive X-ray detectors with low-bias imaging and monitoring
Authors: Jiang Jizhong , Xiong Min , Fan Ke , Bao Chunxiong , Xin Deyu , Pan Zhengwei , Fei Linfeng , Huang Haitao , Zhou Lang , Yao Kai , Zheng Xiaojia , Shen Liang , Gao Feng 
Published: July 2022

AbstractAlthough three-dimensional metal halide perovskite (ABX3) single crystals are promising next-generation materials for radiation detection, state-of-the-art perovskite X-ray detectors include methylammonium as A-site cations, limiting the operational stability. Previous efforts to improve the stability using formamidinium–caesium-alloyed A-site cations usually sacrifice the detection performance because of high trap densities. Here we successfully solve this trade-off between stability and detection performance by synergistic composition engineering, where we include A-site alloys to decrease the trap density and B-site dopants to release the microstrain induced by A-site alloying. As such, we develop high-performance perovskite X-ray detectors with excellent stability. Our X-ray detectors exhibit high sensitivity of (2.6 ± 0.1) × 104 μC Gyair−1 cm−2 under 1 V cm−1 and ultralow limit of detection of 7.09 nGyair s−1. In addition, they feature long-term operational stability over half a year and impressive thermal stability up to 125 °C. We further demonstrate the promise of our perovskite X-ray detectors for low-bias portable applications with high-quality X-ray imaging and monitoring prototypes.
Modeling global 80-80-80 blood pressure targets and cardiovascular outcomes
Authors: Pickersgill Sarah J. , Msemburi William T. , Cobb Laura , Ide Nicole , Moran Andrew E. , Su Yanfang , Xu Xinpeng , Watkins David A. 
Published: July 2022

AbstractAs the leading cause of death worldwide, cardiovascular diseases (CVDs) present major challenges for health systems. In this study, we analyzed the effects of better population blood pressure control in the context of a proposed 80-80-80 target: 80% of individuals with hypertension are screened and aware of their diagnosis; 80% of those who are aware are prescribed treatment; and 80% of those on treatment have achieved guideline-specified blood pressure targets. We developed a population CVD model using country-level evidence on CVD rates, blood pressure levels and hypertension intervention coverage. Under realistic implementation conditions, most countries could achieve 80-80-80 targets by 2040, reducing all-cause mortality by 4–7% (76–130 million deaths averted over 2022–2050) and slowing the rise in CVD expected from population growth and aging (110–200 million cases averted). Although populous middle-income countries would account for most of the reduced CVD cases and deaths, low-income countries would experience the largest reductions in disease rates.
Vertebrate growth plasticity in response to variation in a mutualistic interaction
Authors: Rueger Theresa , Bhardwaj Anjali Kristina , Turner Emily , Barbasch Tina Adria , Trumble Isabela , Dent Brianne , Buston Peter Michael 
Published: July 2022

AbstractVertebrate growth can be phenotypically plastic in response to predator–prey and competitive interactions. It is unknown however, if it can be plastic in response to mutualistic interactions. Here we investigate plasticity of vertebrate growth in response to variation in mutualistic interactions, using clown anemonefish and their anemone hosts. In the wild, there is a positive correlation between the size of the fish and the size of the anemone, but the cause of this correlation is unknown. Plausible hypotheses are that fish exhibit growth plasticity in response to variation in food or space provided by the host. In the lab, we pair individuals with real anemones of various sizes and show that fish on larger anemones grow faster than fish on smaller anemones. By feeding the fish a constant food ration, we exclude variation in food availability as a cause. By pairing juveniles with artificial anemones of various sizes, we exclude variation in space availability as a single cause. We argue that variation in space availability in conjunction with host cues cause the variability in fish growth. By adjusting their growth, anemonefish likely maximize their reproductive value given their anemone context. More generally, we demonstrate vertebrate growth plasticity in response to variation in mutualistic interactions.