bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-Molecular-Weight Heparin Resistance and Its Viscoelastic Assessment in Critically Ill COVID-19 Patients
Authors: Bösch Johannes , Rugg Christopher , Schäfer Volker , Lichtenberger Philipp , Staier Nikolai , Treichl Benjamin , Rajsic Sasa , Peer Andreas , Schobersberger Wolfgang , Fries Dietmar , Bachler Mirjam 
Published: September 2022

AbstractCritically ill COVID-19 patients present an inflammatory and procoagulant status with a high rate of relevant macro- and microvascular thrombosis. Furthermore, high rates of heparin resistance have been described; yet, individualized anticoagulation by drug monitoring has not been sufficiently researched. We analyzed data from critically ill COVID-19 patients treated at Innsbruck Medical University Hospital with routinely adapted low-molecular-weight heparin (LMWH) doses according to anti-Xa peak levels, and regularly performed ClotPro analyses (a viscoelastic hemostatic whole blood test). A total of 509 anti-Xa peak measurements in 91 patients were categorized as below (<0.008 IU/mL/mg), within (0.008–0–012 IU/mL/mg) or above (> 0.012 IU/mL/mg) expected ranges with respect to the administered LMWH doses. Besides intergroup comparisons, correlations between anti-Xa levels and ClotPro clotting times (CTs) were performed (226 time points in 84 patients). Anti-Xa peak levels remained below the expected range in the majority of performed measurements (63.7%). Corresponding patients presented with higher C-reactive protein and D-dimer but lower antithrombin levels when compared with patients achieving or exceeding the expected range. Consequently, higher enoxaparin doses were applied in the sub-expected anti-Xa range group. Importantly, 47 (51.6%) patients switched between groups during their intensive care unit (ICU) stay. Anti-Xa levels correlated weakly with IN test CT and moderately with Russell's viper venom (RVV) test CT. Critically ill COVID-19 patients present with a high rate of LMWH resistance but with a variable LMWH response during their ICU stay. Therefore, LMWH–anti-Xa monitoring seems inevitable to achieve adequate target ranges. Furthermore, we propose the use of ClotPro's RVV test to assess the coagulation status during LMWH administration, as it correlates well with anti-Xa levels but more holistically reflects the coagulation cascade than anti-Xa activity alone.
Management Strategies for Sexuality Complaints after Gynecologic Cancer: A Systematic Review
Authors: Pizetta Luciane Machado , Reis Augusto da Cunha , Méxas Mirian Picinini , Guimarães Vanessa de Almeida , de Paula Carmen Lucia 
Published: September 2022

Abstract
Objective To explore the main sexuality complaints of gynecologic cancer survivors after treatment and to identify the care strategies provided.
Data Source Searches were conducted in six electronic databases: Scopus, Web of Science, LILACS, MEDLINE, PsychINFO, and EMBASE.
Study Selection Articles published between 2010 and 2020 were selected and the following descriptors were used in the English language: female genital neoplasms and gynaecological cancer. The methodological quality of the studies used the Mixed Methods Appraisal Tool (MMAT).
Data Collection The primary data extracted were: names of the authors, year of publication, country of origin, objective and type of study, data collection instrument, sample size and age range, types of cancer, and symptoms affected with the strategies adopted.
Data Summary A total of 34 out of 2,536 screened articles were included. The main strategies found for patient care were patient-clinician communication, practices for sexuality care, individualized care plan, multiprofessional team support, and development of rehabilitation programs. For sexuality care, the most common practices are pelvic physiotherapy sessions and the use of vaginal gels and moisturizers.
Conclusion The main complaints identified in the scientific literature were low libido and lack of interest in sexual activity, vaginal dryness, pain during sexual intercourse, and stenosis. Different care strategies may be adopted, such as follow-up with a multidisciplinary health team and sexual health rehabilitation programs, which could minimize these symptoms and ensure the quality of life of patients.
Predictors of Refractoriness and Survival following Transarterial Chemoembolization for Hepatocellular Carcinoma: Outcomes from a Southeast Asian Cohort
Authors: Kuhn Rudolf V. , Ignacio Glenn Marc G. , Jamias Jade D. , Teh Catherine S.C. 
Published: September 2022

Abstract
Purpose Patients with hepatocellular carcinoma (HCC) become refractory to repeated sessions of transarterial chemoembolization (TACE). The aim of this study was to identify predictors associated with overall survival and refractoriness following repetitive TACE of HCC among patients in Southeast Asia.
Methods The clinical and laboratory characteristics and radiologic response of 39 patients treated with conventional TACE (range 2 to 5) with mitomycin from January 2012 to June 2018 were retrospectively analyzed. Patients were mostly male with a median age of 59 years and belonged to the BCLC B stage with a median tumor size of 7.5 cm.
Results The median overall survival was 23.2 months and the overall mortality at 5 years was 36%. Multivariate Cox regression analysis revealed that Child–Pugh (CP) score (hazard ratio [HR] = 3.47, p = 0.044), AST (HR = 7.6, p = 0.021), tumor size (HR = 5.47, p = 0.033), progressive disease on Choi criteria (HR = 5.47, confidence interval [CI] 1.15–25.99, p = 0.033), neutrophil-lymphocyte ratio (HR = 1.25, p = 0.049), and nodular enhancement on follow-up computed tomography (CT; HR = 1.98, p = 0.034) were independent risk factors for poor survival. ALT (p = 0.005), enhancement (p = 0.003), CP score (p = 0.010), and progressive disease on Choi criteria (p = 0.022) were predictive of TACE refractoriness/failure.
Conclusion Elevated liver enzymes, CP score, and progressive disease on Choi criteria accurately predict TACE refractoriness and failure, allowing early identification of patients who might benefit from other therapies.
Application of Activators Ecarin and Factor Xa in Thrombelastography for Measurement of Anticoagulant Effect of Direct Oral Anticoagulants Using TEG 5000
Authors: Artang Ramin , Brod Camille , Nielsen Jorn Dalsgaard 
Published: September 2022

AbstractThere are situations where monitoring direct oral anticoagulants (DOACs) would be useful, including bleedings and trauma. The thromboelastographic technique has proven useful in bleeding situations in trauma and heart surgery. The aim of this study was to examine the effect of DOACs on all currently commercially available conventional TEG®5000 assays as well as novel modified assay using Ecarin and human factor Xa (HFXa). Healthy male volunteers were given single dose of oral dabigatran 150 mg, rivaroxaban 20 mg, or apixaban 5 mg. Kaolin, RapidTEG, functional fibrinogen, PlateletMapping assay, and novel modified assays using Ecarin and HFXa were prepared. All TEG parameters were recorded. DOAC concentrations were correlated to the parameters with highest response to the DOAC effect. Sensitivity and negative predictive value of the parameter with highest response to DOAC concentration of 50 ng/mL was calculated. None of the conventional TEG assays demonstrated significant response to the effect on apixaban. Using Ecarin, reaction time R was strongly correlated with dabigatran concentrations. Using HFXa assay, R was strongly correlated with rivaroxaban and apixaban concentrations: r = 0.96, 0.84, and 0.86, respectively; p < 0.0001 for all. The R times obtained with the modified assays demonstrated strong sensitivity and negative predictive values for DOAC levels of ≥50 ng/mL. We have demonstrated that TEG®5000 can monitor the DOAC effect on hemostasis when the appropriate activator is used with significant correlation with DOAC concentrations. Larger clinical studies are warranted for correlation of TEG profile and clinical outcomes.
Evaluation of Correlation and Agreement between SpO2/FiO2 ratio and PaO2/FiO2 ratio in Neonates
Authors: Muniraman Hemananda K. , Kibe Rutuja , Namjoshi Abhijeet , Song Ashley Y. , Lakshmanan Ashwini , Ramanathan Rangasamy , Biniwale Manoj 
Published: September 2022

Abstract
Objectives This article evaluates correlation and agreement between oxygen saturation (SpO2)/fraction of inspired oxygen (FiO2) (SF) ratio and partial pressure of oxygen (PaO2)/FiO2 (PF) ratio. It also derives and validates predictive PF ratio from noninvasive SF ratio measurements for clinically relevant PF ratios and derives SF ratio equivalent of PF ratio cutoffs used to define acute lung injury (ALI, PF < 300) and acute respiratory distress syndrome (ARDS, PF < 200).
Methods Retrospective cohort study including neonates with respiratory failure over a 6-year study period. Correlation and agreement between PF ratio with SF ratio was analyzed by Pearson's correlation coefficient and Bland–Altman analysis. Generalized estimating equation was used to derive PF ratio from measured PF ratio and derive corresponding SF ratio for PF ratio cutoffs for ALI and ARDS.
Results A total of 1,019 paired measurements from 196 neonates with mean 28 (± 4.7) weeks' gestational age and 925 (± 1111) g birth weight were analyzed. Strong correlation was noted between SF ratio and PF ratio (r = 0.90). Derived PF ratios from regression (1/PF = –0.0004304 + 2.0897987/SF) showed strong accuracy measures for PF ratio cutoffs < 200 (area under the curve [AUC]: 0.85) and < 100 (AUC: 0.92) with good agreement. Equivalent SF ratio to define ALI was < 450, moderate ARDS was < 355, and severe ARDS was < 220 with strong accuracy measures (AUC > 0.81, 0.84, and 0.93, respectively).
Conclusion SF ratio correlated strongly with PF ratio with good agreement between derived PF ratio from noninvasive SpO2 source and measure PF ratio. Derived PF ratio may be useful to reliably assess severity of respiratory failure in neonates. Further studies are needed to validate SF ratio with clinical illness severity and outcomes.
Von Willebrand Factor Multimer Analysis and Classification: A Comprehensive Review and Updates
Authors: Saadalla Abdulrahman , Seheult Jansen , Pruthi Rajiv K. , Chen Dong 
Published: September 2022

AbstractVon Willebrand factor (VWF) is a multimeric glycoprotein with essential roles in primary hemostasis. Patients with von Willebrand disease (VWD), due to quantitative and/or qualitative defects of VWF usually experience mucocutaneous bleeding. Based on the laboratory results of VWF antigen, various VWF activities, factor VIII activity, and VWF multimer patterns, VWD can be categorized as type 1, 2, and 3 VWD. VWF multimer analysis by either manual or semi-automated electrophoresis and immunoblotting is a critical part of the laboratory testing to differentiate type 1, type 2 VWD, and subtypes of type 1 or 2 VWD. The multimer distribution patterns can also help to understand the underlying molecular mechanism of VWF synthesis, multimerization, and clearance defects in VWD. This review will cover VWF synthesis, multimerization, secretion, VWF multimer analysis, and VWF multimer interpretation of various types and subtypes of VWD.
Epigenetic Alteration in Colorectal Cancer: A Biomarker for Diagnostic and Therapeutic Application
Authors: Essa Hafsa Yousif Solayman , Kusaf Gunay , Yuruker Ozel , Kalkan Rasime 
Published: September 2022

AbstractColorectal cancer (CRC) is the leading cause of cancer death worldwide. A crucial process that initiates and progresses CRC is various epigenetic and genetic changes occurring in colon epithelial cells. Recently, huge progress has been made to understand cancer epigenetics, especially regarding DNA methylation changes, histone modifications, dysregulation of miRNAs and noncoding RNAs. In the “epigenome” of colon cancer, abnormal methylation of genes that cause gene alterations or expression of miRNA has been reported in nearly all CRC; these findings can be encountered in the average CRC methylome. Epigenetic changes, known as driving events, are assumed to play a dominant part in CRC. Furthermore, as epigenetic changes in CRC become properly understood, these changes are being established as clinical biomarkers for therapeutic and diagnostic purposes. Progression in this area indicates that epigenetic changes will often be utilized in the future to prevent and treat CRC.
Fiber-tip endoscope for optical and microwave control
Authors: Dix Stefan , Gutsche Jonas , Waller Erik , von Freymann Georg , Widera Artur 
Published: September 2022

We present a robust, fiber-based endoscope with a silver direct-laser-written structure for radio frequency (RF) emission next to the optical fiber facet. Thereby, we are able to excite and probe a sample, such as nitrogen-vacancy (NV) centers in diamond, with RF and optical signals simultaneously and specifically measure the fluorescence of the sample fully through the fiber. At our targeted frequency range of around 2.9 GHz, the facet of the fiber core is in the near-field of the RF-guiding silver structure, which comes with the advantage of an optimal RF intensity decreasing rapidly with the distance. By creating a silver structure on the cladding of the optical fiber, we achieve the minimal possible distance between an optically excited and detected sample and an antenna structure without affecting the optical performance of the fiber. This allows us to realize a high RF amplitude at the sample’s position when considering an endoscope solution with integrated optical and RF access. The capabilities of the endoscope are quantified by optically detected magnetic resonance (ODMR) measurements of an NV-doped microdiamond that we probe as a practical use case. We demonstrate a magnetic sensitivity of our device of 17.8 nT/Hz when measuring the ODMR exclusively through our fiber and compare the sensitivity to a measurement using a confocal microscope. Moreover, the application of our device is not limited to NV centers in diamonds. Similar endoscope-like devices combining optical excitation and detection with radio frequency or microwave antenna could be used as a powerful tool for measuring a variety of fluorescent particles that have so far only been investigated with bulky and large optical setups. Furthermore, our endoscope points toward precise distance measurements based on Rabi oscillations.
Corrugated, concaved vertically aligned carbon nanotube structures in impeded CVD growth conditions
Authors: Rajab Fahd M. 
Published: September 2022

Vertically Aligned Carbon Nanotubes (VACNT) are promising soft materials in advanced devices, including wearable strain sensors. VACNT uniform growth depends on nucleation, growth, and deactivation of metal seed catalysts by chemical vapor deposition (CVD) at specific process conditions. CVD is performed at controlled process conditions to maximize VACNT growth with iron seed catalysts of various sizes, optimize water vapor concentration for enhanced VACNT growth, and probe their morphology by creating competition of the hydrocarbon feedstock to Fe seed catalyst of selected layer thicknesses. The analytical studies include ellipsometry to measure thermal oxide, barrier layer, and catalyst layer thicknesses; Raman spectroscopy to assess the characteristic peaks of carbon nanotubes; as well as scanning electron microscopy to evaluate VACNT morphology. The findings show a maximum VACNT growth of 1284 µm at 1 nm Fe catalyst, optimum water vapor content at 12.5–20 SCCM, and predominantly concaved and corrugated, a tube chamber position-dependent VACNT structures with low Ar/H2 ratio and C2H4 gas rates.
Symmetry-resolved CO desorption and oxidation dynamics on O/Ru(0001) probed at the C K-edge by ultrafast x-ray spectroscopy
Authors: LaRue Jerry , Liu Boyang , Rodrigues Gabriel L. S. , Liu Chang , Garrido Torres Jose Antonio , Schreck Simon , Diesen Elias , Weston Matthew , Ogasawara Hirohito , Perakis Fivos , Dell’Angela Martina , Capotondi Flavio , Ball Devon , Carnahan Conner , Zeri Gary , Giannessi Luca , Pedersoli Emanuele , Naumenko Denys , Amann Peter , Nikolov Ivaylo , Raimondi Lorenzo , Spezzani Carlo , Beye Martin , Voss Johannes , Wang Hsin-Yi , Cavalca Filippo , Gladh Jörgen , Koroidov Sergey , Abild-Pedersen Frank , Kolb Manuel , Miedema Piter S. , Costantini Roberto , Heinz Tony F. , Luntz Alan C. , Pettersson Lars G. M. , Nilsson Anders 
Published: September 2022

We report on carbon monoxide desorption and oxidation induced by 400 nm femtosecond laser excitation on the O/Ru(0001) surface probed by time-resolved x-ray absorption spectroscopy (TR-XAS) at the carbon K-edge. The experiments were performed under constant background pressures of CO (6 × 10−8 Torr) and O2 (3 × 10−8 Torr). Under these conditions, we detect two transient CO species with narrow 2π* peaks, suggesting little 2π* interaction with the surface. Based on polarization measurements, we find that these two species have opposing orientations: (1) CO favoring a more perpendicular orientation and (2) CO favoring a more parallel orientation with respect to the surface. We also directly detect gas-phase CO2 using a mass spectrometer and observe weak signatures of bent adsorbed CO2 at slightly higher x-ray energies than the 2π* region. These results are compared to previously reported TR-XAS results at the O K-edge, where the CO background pressure was three times lower (2 × 10−8 Torr) while maintaining the same O2 pressure. At the lower CO pressure, in the CO 2π* region, we observed adsorbed CO and a distribution of OC–O bond lengths close to the CO oxidation transition state, with little indication of gas-like CO. The shift toward “gas-like” CO species may be explained by the higher CO exposure, which blocks O adsorption, decreasing O coverage and increasing CO coverage. These effects decrease the CO desorption barrier through dipole–dipole interaction while simultaneously increasing the CO oxidation barrier.
Ab initio quantum scattering calculations for the CO–O2 system and a new CO–O2 potential energy surface: O2 and air broadening of the R(0) line in CO
Authors: Zadrożny Adam , Jóźwiak Hubert , Quintas-Sánchez Ernesto , Dawes Richard , Wcisło Piotr 
Published: September 2022

We present ab initio calculations of the collisional broadening of the R(0) pure rotational line in CO (at 115 GHz) perturbed by O2. Our calculations are done in a fully quantum way by solving close-coupling quantum-scattering equations without any approximations. We also report a new, highly accurate CO–O2 potential energy surface on which we did the quantum-scattering calculations. The calculated collisional broadening agrees with the available experimental data in a wide temperature range. The calculated collisional shift is negligible compared to the broadening, which is also consistent with the experimental data. We combine this result with our previous calculations for the same line in CO perturbed by N2 [Jóźwiak et al., J. Chem. Phys. 154, 054314 (2021)]; the obtained air-perturbed broadening of the R(0) pure rotational line in CO and its temperature dependence perfectly agree with the HITRAN database. This result constitutes an important step toward developing a methodology for providing accurate ab initio reference data on spectroscopic collisional line-shape parameters for molecular systems relevant to the Earth’s atmosphere and for populating spectroscopic line-by-line databases.
Disentangling professional competence and foreign accent
Authors: Teló Cesar , Trofimovich Pavel , Grantham O’Brien Mary 
Published: September 2022

Abstract
This study examined listeners’ evaluations of first (L1) and second language (L2) English speech in work-related contexts. Ninety-six English-speaking listeners from Calgary rated audio recordings of 12 English speakers (6 L1 English, 6 L1 Tagalog) along three continua capturing one professional (competence), one experiential (treatment preference), and one linguistic (comprehensibility) dimension. The audio recordings additionally differed in terms of job prestige (high vs. low) and performance level (high vs. low). Compared to English speakers, Tagalog speakers were rated as less competent and comprehensible overall, and listeners wished to be treated more like the clients in scenarios recorded by English than Tagalog speakers, with all effects magnified for speakers with heavier foreign accents. Nonetheless, listeners generally evaluated English and Tagalog speakers similarly in low-prestige and in low-performance scenarios, but rated low performance less negatively in low-prestige positions. Findings demonstrate highly nuanced accent bias in work-related contexts.
Emotion in speech
Authors: Ariztimuño Lilián I. , Dreyfus Shoshana , Moore Alison Rotha 
Published: September 2022

AbstractThis paper explores how emotion is conveyed in spoken language based on a sample of three stories for children read aloud by a trained storyteller. It draws on both Martin & White’s appraisal framework (2005) and a systematic account of vocal features. Interpreting and profiling emotion is a challenge both for researchers interested in spoken language and for English-as-an-additional-language teachers, when working to improve students’ spoken expression of emotion. Underpinning this challenge is the absence of a unified theoretical stance and a consequent lack of shared analytical tools for describing how speakers use semiotic resources to convey emotion in their speech. A systemic functional semiotic approach can make visible the co-patterning of wordings and vocalisations that express emotion.
Evaluating Jesus and other “heroes”
Authors: Lamb David A. , Tenbrink Thora 
Published: September 2022

AbstractThe appraisal framework developed by Martin and White and others working within systemic functional linguistics has been applied in a wide variety of contexts. However, to our knowledge, it has been little used in the interpretation of ancient written documents. We believe that it may have value, amongst other things, in determining the genre of such literature and we see this as particularly relevant in the area of biography, where the author’s presentation of the subject is a key factor. So, in this study, we apply aspects of the appraisal framework to three Hellenistic Greek texts often categorised with the genre “Lives”. Selected passages from these texts were divided into short units for quantitative analysis that focused on theJudgementthat the texts’ authors make of their central characters (their “heroes”), how this isamplifiedand how theyengagewith different “voices”. These passages were also compared with the rest of the texts in a more qualitative study. Our results show notable differences in theJudgementthe authors make and presumably wish their readers to share in terms of the positive/negative portrayal of their “heroes”, the degree of amplification and the interaction with other “voices”. We consider the appropriateness of the “Lives” genre for one of these texts, theGospel of John, and also a number of methodological issues arising from an area of application that has not previously received attention. These include the difficulty of making clear-cut evaluation choices where authors themselves may be ambivalent about those they are describing and the need to take account of the differing and complex value systems of ancient cultures. We suggest that our findings may have wider relevance for other applications of appraisal.
Derisive laughter and religious identity in ancient Christianity
Authors: Sælid Gilhus Anne Ingvild 
Published: September 2022

Abstract
Polemic and mockery were part of Christian identity-making, especially in apologies and
heresiologies, where boundaries were created against pagans and other Christians. In this paper, the focus is on the
use of derisive laughter in the Nag Hammadi texts. This chapter presents a survey of four variants of the
laughter-motif, discusses them and investigates what they have to say about Christian monastic identity in the fourth
to fifth century in Upper Egypt. It appears that the motif works as a powerful rhetorical instrument and pedagogical
tool. It contributed to guide the readers in the right direction – towards spirituality and superior knowledge, but it
was not necessarily intended to make them laugh out loud.