bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced brain activity during a working memory task in middle-aged apolipoprotein E ε4 carriers with overweight/obesity
Authors: Drake Jermon A. , Jakicic John M. , Rogers Renee J. , Aghjayan Sarah L. , Stillman Chelsea M. , Donofry Shannon D. , Roecklein Kathryn A. , Lang Wei , Erickson Kirk I. 
Published: November 2022

ObjectiveThe apolipoprotein E ε4 (APOE ε4) allele and midlife obesity are independent risk factors for Alzheimer’s disease (AD). Both of these risk factors are also associated with differences in brain activation, as measured by blood oxygenation level-dependent (BOLD) responses, in the absence of detectable cognitive deficits. Although the presence of these risk factors may influence brain activity during working memory tasks, no study to date has examined whether the presence of the ε4 allele explains variation in working memory brain activity while matching for levels of overweight/obesity. The primary aim of this study was to determine whether the presence of the ε4 allele is associated with differences in task-functional magnetic resonance imaging (fMRI) brain activation in adults with overweight/obesity. We predicted that ε4 carriers would have greater brain activation in regions that support working memory.MethodsThis ancillary study included 48 (n = 24 APOE ε4 carriers; n = 24 APOE ε4 non-carriers), sedentary middle-aged adults (Mean age = 44.63 ± 8.36 years) with overweight/obesity (Mean BMI = 32.43 ± 4.12 kg/m2) who were matched on demographic characteristics. Participants were a subsample enrolled in 12-month randomized clinical trial examining the impact of energy-restricted diet and exercise on cardiovascular health outcomes. Participants completed a n-back working memory task with fMRI, which were completed within one month of the start of the intervention. Participants also underwent pseudo-continuous arterial spin labeling scans, a MRI measure of cerebral blood flow (CBF).ResultsCompared to non-ε4 carriers with overweight/obesity, ε4 carriers with overweight/obesity had lower fMRI brain activity in the middle frontal gyrus, pre and post central gyrus, supramarginal gyrus, superior temporal gyrus, lateral occipital cortex, and angular gyrus (z range = 2.52–3.56) during the n-back working memory task. Differences persisted even when controlling for CBF in these brain regions.ConclusionThese results indicate that presence of the APOE ε4 allele in middle-aged adults with overweight/obesity is related to altered brain activity during a working memory paradigm, which may confer risk for accelerated neurocognitive decline in late adulthood. Future research is needed to clarify the clinical implications of these findings in the context of risk for AD.
Underlying reasons for post-mortem diagnosed lung cancer cases – A robust retrospective comparative study from Hungary (HULC study)
Authors: Kiss Zolta´n , Bogos Krisztina , Tamási Lilla , Ostoros Gyula , Müller Veronika , Bittner Nóra , Sárosi Veronika , Vastag Aladár , Knollmajer Kata , Várnai Máté , Kovács Krisztina , Berta Andrea , Köveskuti István , Karamousouli Eugenia , Rokszin György , Abonyi-Tóth Zsolt , Barcza Zsófia , Kenessey István , Weber András , Nagy Péter , Freyler-Fadgyas Petra , Szócska Miklós , Szegner Péter , Hilbert Lászlóné , Géczy Gabriella Branyiczkiné , Surján György , Moldvay Judit , Vokó Zoltán , Gálffy Gabriella , Polányi Zoltán 
Published: November 2022

ObjectiveThe Hungarian Undiagnosed Lung Cancer (HULC) study aimed to explore the potential reasons for missed LC (lung cancer) diagnosis by comparing healthcare and socio-economic data among patients with post-mortem diagnosed LC with those who were diagnosed with LC during their lives.MethodsThis nationwide, retrospective study used the databases of the Hungarian Central Statistical Office (HCSO) and National Health Insurance Fund (NHIF) to identify patients who died between January 1, 2019 and December 31, 2019 and were diagnosed with lung cancer post-mortem (population A) or during their lifetime (population B). Patient characteristics, socio-economic factors, and healthcare resource utilization (HCRU) data were compared between the diagnosed and undiagnosed patient population.ResultsDuring the study period, 8,435 patients were identified from the HCSO database with LC as the cause of death, of whom 1,203 (14.24%) had no LC-related ICD (International Classification of Diseases) code records in the NHIF database during their lives (post-mortem diagnosed LC population). Post-mortem diagnosed LC patients were significantly older than patients diagnosed while still alive (mean age 71.20 vs. 68.69 years, p&lt;0.001), with a more pronounced age difference among female patients (difference: 4.57 years, p&lt;0.001), and had significantly fewer GP (General Practitioner) and specialist visits, X-ray and CT scans within 7 to 24 months and 6 months before death, although the differences in GP and specialist visits within 7–24 months did not seem clinically relevant. Patients diagnosed with LC while still alive were more likely to be married (47.62% vs. 33.49%), had higher educational attainment, and had more children, than patients diagnosed with LC post-mortem.ConclusionsPost-mortem diagnosed lung cancer accounts for 14.24% of total lung cancer mortality in Hungary. This study provides valuable insights into patient characteristics, socio-economic factors, and HCRU data potentially associated with a high risk of lung cancer misdiagnosis.
Prognostic value and immune infiltration of the gasdermin family in lung adenocarcinoma
Authors: Peng Lu-Shan , Duan Sai-Li , Li Run-Qi , Wang Dan , Han Ying-Ying , Huang Tao , Yu Yu-Pei , Ou Chun-Lin , Wang Jun-Pu 
Published: November 2022

BackgroundThe GSDM family includes six members, GSDMA, GSDMB, GSDMC, GSDMD, GSDME (DFNA5), and PJVK (Pejvakin, DFNB59), which can induce pyroptosis, thereby regulating the tumorigenesis of various cancers. However, the clinical characteristics and role of the GSDM family in LUAD are not well understood.MethodsIn this study, several important bioinformatics databases were used to integrate the analysis of the expression, prognostic value, and immune infiltration of GSDMs in LUAD. These databases include UALCAN, DiseaseMeth, GEPIA, THPA, cBioPortal, TIMER, WebGestalt, STRING database, and Cytoscape.ResultsThe findings from the UALCAN database revealed that the expression of all six GSDMs based on the tumor stage in LUAD was increased (particularly GSDMD). Our IHC results verified it. Additionally, the DiseaseMeth database showed that the methylation levels of GSDMA, GSDMB, GSDMC, and GSDMD were decreased. The expression of six GSDMs was related to shorter overall survival in patients with LUAD, according to the GEPIA database. The cBioPortal database was further used to explore the alteration rate and correlated genes in LUAD. Subsequently, these genes were subjected to functional enrichment and protein-protein interaction network analyses. We identified that the GSDM family regulate several signaling pathways, including immune-associated signaling pathways. According to tumor-infiltrating immune cell analysis from the TIMER database, GSDM family members are associated with the infiltration of important immune cells and their signature markers.ConclusionsGSDM family may be prognostic markers and novel strategies for the treatment of LUAD.
Optimizing maize yields using growth stimulants under the strategy of replacing chemicals with biological fertilizers
Authors: Abdo Ahmed I. , El-Sobky El-Sayed E. A. , Zhang Jiaen 
Published: November 2022

Partial replacement of chemicals with biological fertilizers is a recommended strategy to reduce the adverse environmental effects of chemical fertilizer losses. Enhancing the reduced mineral with biological fertilizers strategy by foliar application of humic acid (HA) and amino acids (AA) can reduce environmental hazards, while improving maize (Zea mays L.) production under semiarid conditions. The recommended doses of N, P and K (e.g., 286 kg N ha-1, 75 kg P2O5 ha-1 and 67 kg K2O ha-1) were applied as the first fertilization level (100% NPK) and were replaced with biofertilizers by 100%, 75%, 50% and 25% as levels of reducing mineral fertilization. These treatments were applied under four foliar applications of tap water (TW), HA, AA and a mixture of HA and AA. Our results reported significant reductions in all parameters, including maize ear yield attributes and grain nutrient uptake, when replacing the mineral NPK with biofertilizers by 25-100% replacement. However, these reductions were mitigated significantly under the application of growth stimulants in the descending order: HA and AA mixture&gt;AA&gt;HA&gt;TA. Applying a mixture of HA and AA with 75% NPK + biofertilizers increased ear length, grain yield, grain uptake of N and K, and crude protein yield by 37, 3, 4, 11 and 7%, respectively as compared with 100% mineral fertilizer only. Moreover, all investigated parameters were maximized under the application of 75% NPK + biofertilizers combined with AA or the mixture of HA and AA, which reveals the importance of growth stimulants in enhancing the reduced chemical NPK strategy. It could be concluded that the mineral NPK rate can be reduced by 25% with biofertilization without any yield losses when combined with HA and AA under arid and semi-arid conditions. That achieves the dual goals of sustainable agriculture by improving yield, while reducing environmental adverse effects.
Anti-BLV antibodies in whey correlate with bovine leukemia virus disease progression and BoLA-DRB3 polymorphism
Authors: Nakatsuchi Ayumi , Bao Aronggaowa , Watanuki Sonoko , Matsuura Ryosuke , Borjigin Liushiqi , Bai Lanlan , Kuroda Maho , Matsumoto Yasunobu , Kohara Junko , Aida Yoko 
Published: November 2022

IntroductionBovine leukemia virus (BLV) belongs to the family Retroviridae and is a causative agent for enzootic bovine leucosis, the most common neoplastic disease affecting cattle worldwide. BLV proviral load (PVL) is associated with disease progression and transmission risk but requires blood collection and quantitative PCR testing. Anti-BLV antibodies in whey have been used as a diagnostic tool for BLV infection; however, quantitative utilization has not been fully investigated. Furthermore, bovine leukocyte antigen (BoLA)-DRB3 is a polymorphic gene associated with BLV infectivity and PVL, but its effect on anti-BLV antibody levels in whey from BLV infected dams is unknown. Therefore, we aimed to investigate whether it is possible to correctly predict PVL in the blood and milk based on the amount of anti-BLV antibodies in milk, and whether the BoLA-DRB3 alleles associate with the amount of anti-BLV antibodies in milk.MethodsWe examined whey from 442 dams from 11 different dairy farms located in 6 prefectures in Japan, including susceptible dams carrying at least one BoLA−DRB3*012:01 or *015:01 allele related with high PVL, resistant dams carrying at least one BoLA-DRB3*002:01, *009:02, or *014:01:01 allele related with low PVL, and neutral dams carrying other alleles.ResultsFirst, our results provided compelling evidence that anti-BLV antibody levels in whey were positively correlated with the anti-BLV antibody levels in serum and with BLV PVL in blood and milk, indicating the possibility of estimating BLV PVL in blood and milk by measuring anti-BLV antibody levels in whey. Thus, our results showed that antibody titers in milk might be effective for estimating BLV transmission risk and disease progression in the field. Second, we demonstrated that anti-BLV antibody levels in whey from BLV resistant dams were significantly lower than those from susceptible and neutral dams.DiscussionThis is the first report suggesting that the BoLA-DRB3 polymorphism affects anti-BLV antibody levels in whey from BLV-infected dams. Taken together, our results suggested that anti-BLV antibody levels in whey, measured by enzyme-linked immunosorbent assay, may be a useful marker to diagnose the risk of BLV infection and estimate PVL in blood and milk.
Evaluation and Application of an Engineering Calculation Method of the Static Performance of an Aerostatic Journal Bearing with Multiple Orifice-Type Restrictors
Authors: Wu Yangong , Qiao Zheng , Chen Wentao , Xue Jiadai , Wang Bo 
Published: November 2022

A simplified calculation method is evaluated to calculate the static performance of an aerostatic journal bearing with multiple orifice-type restrictors. This method adopts a one-dimension flow assumption and is a fast calculation method to design journal bearings in engineering by directly linking the structural parameters and performance parameters affecting radial bearings with nonlinear equations. In addition, this method is verified with computational fluid dynamics by two actual case studies, and it is found that the LCC difference between those two methods is less than 5% for a 200 mm diameter spindle, and less than 10% for a 100 mm diameter spindle. Subsequently, the influence of a key parameter ζi on the static performance of journal bearings is explained theoretically. This method is much easier and more intuitive compared with numerical computational methods. Furthermore, it promotes the application of aerostatic journal bearings.
Developing Teaching Materials of Academic Reading for Third Semester of English Department of Qomaruddin University
Authors: Masruroh Lailatul 
Published: November 2022

In learning activities, teaching materials play a critical role. Teaching materials have appealing designs that encourage students to learn and use them as a study resource. The goal of this study was to figure out and develop what kind of teaching materials are used in academic reading classes. This study employs the research and development technique, as well as the Borg and Gall models. There are ten stages of Borg and Gall models, but The author generates teaching materials in the fourth stage of Borg and Gall model only because the author wants to do this research fast; they are the production of initial drafts of materials for teaching. The type of materials of teaching from this research is handouts of academic reading, Academic reading was taught in the third semester of the English department of education faculty at the Qomaruddin University. So the subject of this research was students who are in semester three of the English Department of Qomaruddin University, some twenty-seven students consisting of twenty-two females and Five males. based on the findings of the development from teaching materials that have been already done. The Specific instructional objectives, instructional analysis, behavior analysis of learner, specific instructional objectives, and also syllabus are needed to create the handouts of teaching materials
PENGARUH IPK DAN MASA STUDI TERHADAP WAKTU TUNGGU MENDAPATKAN PEKERJAAN
Authors: Kiri Trismawati Piga , Atti Astri 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui model regresi linier berganda mengenai pengaruh IPK dan masa studi terhadap waktu tunggu mendapatkan pekerjaan, dan variabel yang paling signfikan dalam mempengaruhi waktu tunggu mendapatkan pekerjaan. Penelitian ini menggunakan pendekatan deskriptif kuantitatif. Subjek penelitian ini adalah Alumni Prodi Matematika FST UNDANA dengan pengambilan sampel sebanyak 95 responden. Metode pengumpulan data yang digunakan adalah kuesioner. Teknik analisis yang digunakan adalah analisis regresi linier berganda. Hasil penelitian ini adalah model regresi linier berrganda untuk pengaruh IPK dan masa studi terhadap waktu tunggu mendapatkan pekerjaan pertama yakni Y=0,555-0,080X1+0,021X2, dan tidak ada variabel yang dominan dalam mempengaruhi waktu tunggu mendapatkan pekerjaan karena berdasarkan hasil pengujian hipotesis secara parsial IPK dan masa studi Alumni Prodi Matematika FST UNDANA tidak mempengaruhi waktu tunggu mendapatkan pekerjaan pertama.
PENGARUH PENGGUNAAN OBAT NYAMUK, KARAKTERISTIK BALITA DAN PERILAKU KELUARGA TERHADAP KEJADIAN INFEKSI SALURAN PERNAPASAN AKUT (ISPA) PADA BALITA
Authors: Ollo Tris Mariana , Atti Astri , Lobo Maria , Kleden Maria 
Published: November 2022

Infeksi Saluran Pernapasan Akut adalah penyakit infeksi yang menyerang salah satu bagian atau lebih dari saluran pernapasan. Penelitian ini bertujuan untuk mencari faktor-faktor dan faktor yang dominan mempengaruhi kejadian Infeksi Saluran Pernapasan Akut pada balita di Puskesmas Nulle, Kabupaten Timor Tengah Selatan. Data yang digunakan dalam penelitian ini yaitu jumlah balita penderita Infeksi Saluran Pernapasan Akut, jenis kelamin balita, berat badan lahir, ASI eksklusif, status imunisasai, status gizi, umur ibu, pendidikan ibu, pendapatan keluarga, keluarga merokok, penggunaan obat nyamuk dan bahan bakar memasak. Dalam penelitian ini, digunakan metode Analisis Faktor untuk menganalisis dalam hal ini mereduksi dua belas (12) variabel penelitian sehingga diperoleh tiga (3) faktor baru yang disebut faktor penggunaan obat nyamuk dan polusi udara, faktor karakteristik balita serta faktor keluarga merokok dengan variansnya berturut-turut adalah: 30,681%, 19,805% dan 13,510% dengan nilai eigennya 2,454, 1,584 dan 1,081. Sehingga diperoleh faktor yang dominan mempengaruhi kejadian Infeksi Saluran Pernapasan Akut pada balita adalah faktor penggunaan obat nyamuk dan polusi udara yaitu dengan varians sebesar 30,681% dan nilai eigen sebesar 2,454.
ESTIMASI BILANGAN REPRODUKSI DASAR PENYEBARAN PENYAKIT TUBERKULOSIS DI KABUPATEN BIMA TAHUN 2022
Authors: Ariyanto Ariyanto , Pangaribuan Rapmaida M. 
Published: November 2022

Telah dilakukan penelitian untuk mencari nilai estimasi bilangan reproduksi dasar penyebaran penyakit tuberkulosis di Kabupaten Bima dengan menggunakan model matematika SEIR. Penyebaran penyakit tuberkulosis di Kabupaten Bima dari bulan November tahun 2021 sampai dengan April tahun 2022 mengalami trend penurunan kasus yang sangat signifikan. Berdasarkan hasil analisis data lapangan dari Dinas Kesehatan Kabupaten Bima diperoleh nilai estimasi bilangan reproduksi dasar sebesar . Karena nilai bilangan reproduksi dasar lebih kecil dari satu, penyebaran penyakit tuberkulosis pada durasi waktu tersebut di atas akan hilang dari populasi Kabupaten Bima.
Religiosidade brasileira: apontamentos
Authors: Tomé Maria Dulce Silva 
Published: November 2022

Religião e cultura, ainda que palavras etimologicamente distintas, em suas simbologias e representações fundem-se na construção da identidade do povo brasileiro. Um olhar sobre as festas nacionais revela-nos esse entrelaçamento entre religião e a cultura brasileira: O Ciro de Nazaré, Festa de São João, Folia dos Reis, Festa do Divino, Cavalhada... Interessante observar que o Carnaval, maior festa popular brasileira, ainda que de natureza profana tenha sua data de comemoração marcada de modo que, a quarta-feira de cinzas, ocorra concomitantemente com o início da quaresma que antecede a páscoa. Sendo a religiosidade parte integrante do ser humano, para a compreensão da mesma, faz-se necessário o conhecimento da sua formação na história. Esse ensaio é fruto de uma reflexão tendo como ponto de partida o livro Matriz religiosa brasileira, de José Bittencourt Filho e o artigo Cultura brasileira e religião... passado e atualidade..., de Pierre Sanchis.
AS INFLUÊNCIAS DO CETICISMO PIRRÔNICO NO RACIOCINO FILOSÓFICO DO SÉCULO XVI E XVIII
Authors: Alves Lion Granier 
Published: November 2022

O presente artigo procura discorrer brevemente sobre influência do ceticismo pirrônico no pensamento filosófico do século XVI E XVIII. Foi analisado o ceticismo e religião em Michel de Montaigne a partir da leitura de alguns textos de Giovanni Reale. Foi proposto uma discussão sobre a problemática do questionamento dos critérios de verdade e da nova espiritualidade a partir do pensamento teológico de Martinho Lutero. Foi finalizado com uma tentativa de compreender as contribuições do ceticismo antigo na filosofia iluminista do século XVIII, a partir a libertação dos dogmas metafísicos, das supertições e tradições religiosas ante o raciocínio filosófico iluminista.
MÍDIA, EMPREENDEDORISMO E PODER: O CASO DA IGREJA UNIVERSAL DO REINO DE DEUS
Authors: Granier Alves Granier 
Published: November 2022

O presente artigo procura discorrer brevemente sobre o crescimento da IURD no campo religioso brasileiro, da sua origem até 1990. Foi analisado o crescimento expressivo da denominação religiosa a partir do rádio e da tevê. A instituição inovou o modelo de igreja brasileira, rompendo com modelos tradicionais, sofreu rupturas e inovações, a partir disso, trouxe uma nova parceria entre os meios de comunicação social e a religião. A igreja promoveu para a religião, uma experiências inédita através dos meios de comunicação social, tornando seu crescimento expressivo. Outro fator fundamental para sua expansão no território nacional foi à retórica. Dotada de técnicas persuasivas, a denominação usa a retórica somada a técnicas empreendedoras para conseguir persuadir os ouvintes.
O MUNDO DOS MORTOS NO ANTIGO EGITO: INTERPRETAÇÃO SOCIOLÓGICA DOS FUNERAIS EGÍPCIOS EM PERSPECTIVA DURKHEIMIANA.
Authors: Corona George Francisco 
Published: November 2022

Os rituais religiosos mais antigos da humanidade são os funerários, e o Egito Antigo se interessou muito por este tema. Suscita-se uma questão: há um significado sociológico para as crenças e práticas funerárias egípcias? Para responder a esta indagação foram analisados os rituais funerários egípcios, buscando o seu sentido social à luz do pensamento de Émile Durkheim. Para este sociólogo o significado dos rituais funerários egípcios é manter a coesão social e evitar a todo custo sua desagregação. A manutenção do pensamento mitológico é decisiva para manter o controle social, a ordem e a unidade política e territorial do país. Logo, tudo o que os funerais explicam sobre a morte e suas consequências, também explicam sobre a vida em sociedade e suas necessidades de preservação. O ideal egípcio de vida eterna e pós-morte era o seu ideal de vida social. Entender a morte egípcia é entender, na realidade, sua vida.Palavras-chave: Rituais Funerários. Egípcio. Durkheim. Sociedade.
DIÁLOGOS ENTRE A FORMAÇÃO INICIAL EM CIÊNCIAS DA RELIGIÃO E A LIBRAS: UM ESTUDO DE CASO
Authors: Veira Silvio Santiago , Dias Diego Jonata Carvalho 
Published: November 2022

Pesquisa realizada com alunos do Curso de Licenciatura em Ciências da Religião (CR) da Universidade do Estado do Pará (UEPA). Tratou-se de uma pesquisa qualitativa que, à luz da análise do discurso buscou verificar quais as principais dificuldades encontradas no seu processo de formação inicial, para o trato com o aluno Surdo incluído nas aulas de Ensino Religioso (ER), a partir do convívio com a disciplina Língua Brasileira de Sinais (Libras). Foi aplicada uma entrevista contendo cinco questões abertas. Os sujeitos da pesquisa foram seis alunos. A pesquisa demonstra a relevância da inclusão na educação hodierna, contudo observamos que ainda faltam muitos desafios na formação do professor para a escola comum ser inclusiva, de fato, como é na perspectiva da educação bilíngüe para Surdos. Parte desses sujeitos, afirmaram que não tiveram contato com turmas inclusivas, nem mesmo no período de estágio e nem foram instigados a participar de tais turmas. PALAVRAS-CHAVE: Ciências da Religião. Formação de Professores. Ensino Religioso. Inclusão. Surdo.
DO SOCIAL AO AMBIENTAL: OS “MOVIMENTOS” DA TEOLOGIA DA LIBERTAÇÃO
Authors: Silva José Andreze 
Published: November 2022

O presente texto tem como objeto de estudo o desenvolvimento da Teologia da Libertação nos documentos conclusivos das Conferências Episcopais da América Latina e do Caribe – CELAM: de Medellín a Santo Domingo em 1992 entre outros e livros. Analisei a Teologia da Libertação como uma teologia de movimento. Movimento no sentido de mover-se, pois ela move-se no transcorrer do tempo sempre que ao fazer uma leitura do contexto sócio-histórico ela busca responder aos desafios encontrados nesta leitura. Para isso, apoiou-se em teorias sociais, como o marxismo, para reformulação teológica, visando conferir eficácia política à fé. É uma teologia que se faz em três momentos, vendo, julgando e agindo. E a Igreja é conclamada a essa tríade em cumprimento de sua missão, optando pelos pobres e conscientizando a sociedade quanto à crise ambiental.