bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of Traditional and Nontraditional Network Involvement in Insulo-Sylvian Gliomas: An Anatomic Study using the Quicktome Platform
Authors: Wu Zhiqiang , Zhang Zifeng , Hu Guanjie , Wang Xiefeng , Zhao Lin , Wang Binbin , Liu Ning , Dadario Nicholas , Zheng Yan , Zhang Junxia , Sughrue Michael , You Yongping 
Published: January 2022

Abstract
BackgroundNeurosurgeons are increasingly capable of maintaining language and motor functions in glioma patients following surgery due to the ability to preserve traditionally “eloquent” structures. However, glioma patients continue to present with severe morbidity in cognitive functions due to the lack of familiarity in the neurosurgical community with non-traditionally “eloquent” brain networks. Therefore, the authors sought to identify and describe the frequency of invasion and/or proximity of Insulo-Sylvian gliomas to portions of non-traditional, large scale brain networks during surgery.MethodsA retrospective analysis was completed of consecutive adult patients undergoing surgery for newly diagnosed glioma at a single center between 2017-2020 with WHO grade II-IV infiltrating gliomas centered in the insula, opercular cortices or temporal stem. Diffusion tensor imaging (DTI)-based tractography was completed by creating a personalized brain connectome atlas based on the Human Connectome parcellation scheme with Quicktome software. This algorithm utilizes an machine learning (ML)-approach to assign voxels of the cerebral cortex to various brain regions according to structural connectivity patterns of voxels in the brain region of interest utilizing neuroimaging data specifically from normal healthy adults. Insulo-Sylvian tumors were categorized based on their involvement with non-traditional cognitive networks versus traditionally eloquent structures.Results45 patients were included (47±15 years, 51% female) consisting of mostly high grade (IV)-gliomas (56%) compared WHO grade II (22%) or III (22% tumors). Ultimately, 44/45 (98%) patients demonstrated tumor involvement (<1cm proximity or invasion) to the cortical or subcortical components of a non-traditional, large scale brain network or major white matter pathway involved in cognition. In comparison, 35/45 (78%) patients demonstrated tumor involvement of traditionally considered “eloquent” structures like the corticospinal tract or language regions/tracts. The most common non-traditional cognitive networks involved in cases included the salience network (60%) followed by the central executive network (56%). ConclusionsNon-traditionally “eloquent” brain networks are increasingly encountered during surgical resection of Insulo-Sylvian gliomas in both hemispheres and must be considered moving forward. Damage or dysfunction in these networks has been shown to result in severe cognitive morbidity and an improved understanding of their presence can allow for more informed surgical decisions based on patient onco-functional goals.
A Practical Swelling Constitutive Model of Anhydrite and its Application on Tunnel Engineering
Authors: Hou Zhenkun , Wu Jianxun 
Published: January 2022

Abstract
Swelling of anhydrite rock is a major threat in tunneling engineering, causing serious damage to tunnels as well as producing high additional costs during tunnel construction and operation. Reliable prediction of swelling pressures and deformations based on conventional swelling constitutive models is extremely difficult. This paper focuses on developing a practical swelling constitutive model of anhydrite for tunnel engineering. Firstly, swelling tests of natural anhydrite samples, focusing on time effect, were designed and conducted. The test results show swelling strain-time can be better described by S-curve model, and swelling stress-strain can be better described by quadratic model. Secondly, a swelling constitutive model with consideration of time effect was developed to reproduce the swelling behavior of anhydrite observed in swelling tests. This model can track the evolution of swelling activity in the tunnelling, which has practical significance for process simulation and process control of swelling disaster. Then this model was implemented within ANSYS for numerical simulation of Lirang tunnel. Based on simulation results, some useful measures were proposed and applied to this tunnel, and got a satisfactory result according to the on-site feedback information.
Designing Rare Disease Care Pathways in the Republic of Ireland – A Co-operative Model
Authors: Ward A J , Murphy Daniel , Marron Rita , McGrath V , Bolz-Johnson M , Cullen Walter , Daly Avril , Hardiman Orla , Lawlor A , Lynch Sally Ann , MacLachlan Mac , McBrien Jackie , O'Byrne James , Turner Jacqueline , O'Connell Susan , Treacy Eileen P 
Published: January 2022

Abstract
Background: Rare diseases (RDs) are often complex, serious, chronic and multi-systemic conditions, associated with physical, sensory and intellectual disability. Patients require follow-up management from multiple medical specialists and health and social care professionals (HSCPs) involving a high level of integrated care, service coordination and specified care pathways.Methods and Objectives: This pilot study aimed to explore the best approach for developing national RD care pathways in the Irish healthcare system in the context of a lack of agreed methodology. Irish clinical specialists and patient/lived experience experts were asked to map existing practice against evidence-based Clinical Practice Guidelines (CPGs) and best practice recommendations from the European Reference Networks (ERNs) to develop optimal care pathways. The study focused on the more prevalent, multisystemic rare conditions that require multidisciplinary care, services, supports and therapeutic interventions. Results: 29 rare conditions were selected across 18 ERNs, for care pathway development. Multidisciplinary input from multiple specialisms was relevant for all pathways. A high level of engagement was experienced from clinical leads and patient organisations. CPGs were identified for 26 of the conditions. Nurse specialist, Psychology, Medical Social Work and Database Manager roles were deemed essential for all care pathways. Access to the therapeutic Health Service Professionals: Physiotherapy, Occupational Therapy, and Speech and Language Therapy were seen as key requirements for holistic care. Genetic counselling was highlighted as a core discipline in 27 pathways demonstrating the importance of access to Clinical Genetics services for many people with RDs. Conclusions: This study proposes a methodology for Irish RD care pathway development, in collaboration with patient/service user advocates. Common RD patient needs and health care professional interventions across all pathways were identified. Key RD stakeholders have endorsed this national care pathway initiative. Future research focused on the implementation of such care pathways is a priority.
Effects of metal leachates from hydrothermal ore particulates in the marine copepod Tigriopus japonicus
Authors: Han Jeonghoon , Park Yeun , Jeong Hyeryeong , Kim Sang Bae , Yoo Chan Min , Hyeong Kiseong , Lee Kyun-Woo 
Published: January 2022

Abstract
We investigated the effects of metal leachates from hydrothermal ore particulates on the physiological and molecular responses of the marine copepod Tigriopus japonicus. We evaluated its life cycle parameters including survival, development, and fecundity and the transcriptional profiles of its genes regulating detoxification (cytochrome P450 [CYP]), antioxidation (glutathione S-transferase [GST]), and development (vitellogenin [Vtg]) in response to hydrothermal ore and beneficiation leachates. There were preponderances of copper, iron, and zinc in the hydrothermal ore and the leachates derived from it. There were no significant changes in copepod developmental time in response to leachate exposure. However, copepod survival and fecundity significantly changed in response to the leachates. Moreover, the transcriptional profiles of the detoxification, antioxidation, and development-related genes were significantly modulated following leachate treatment. Collectively, our results suggest that metal leachates from hydrothermal ore particulates can promote the transcriptional expression of detoxification, antioxidation, and development-related genes, and altered survival and fecundity in T. japonicus.
Ab Initio DFT Study of Polysaccharides To Predict Their Applicability In Wound Healing
Authors: Tripathi Shikha , Dadhich Bharat , Tripathi Manwendra Kumar , Kumar Awanish 
Published: January 2022

Abstract
A wound-healing patch is used to help in this repairing process in which the dermal patch has been proven to be the fastest and economical way to help. Nowadays more attention is being paid to the use of biodegradable polymers for making efficient biocomposite films. In this study, we have explored the properties of some polysaccharides that can be used for wound healing. In recent years ab initio method for electronic structure study is being used frequently. We have done the density function theory (DFT) calculations of polysaccharides (Alginic acid, Chitosan oligosaccharide, Chitosamine hydrochloride, Ethylcellulose, and Sodium carboxymethyl cellulose) using SIESTA software to know its structure/interaction at the molecular level. This information is helpful to understand the blending possibility of the above-mentioned biopolymers so that their patches can be cast easily for wound healing application. Further MD simulation calculations decipher the virial energy, order parameters, and accumulation time averages of biopolymers that could play useful information in storing biopolymeric blends for long time storage. DFT study has shown that chitosan oligosaccharide is thermally most unstable whereas chitosamine hydrochloride is most stable. Also, chitosan oligosaccharide has the highest density and lowest is of chitosamine hydrochloride at a similar energy level. The range of density at different states and structures of polymer helps in predicting homogenous blends. Overall, this study could help in providing insights for the formulation of effective blends of these polymers to obtain better biocomposite material with desired properties that could be used as efficient biocomposite films/patches in wound healing.
The Prevalence and Associated Factors of Depression Among Residents in Training
Authors: Karawekpanyawong Nuntaporn , Chimnuan Kamolchanok , Orrapin Saranat , Kawilapat Suttipong , Wiriyacosol Punjaree 
Published: January 2022

Abstract
Background: Residency training causes high stress and leads to depression.Aims: This study aims to investigate the prevalence and factors associated with depression in residents.Methods: This cross-sectional, single-site study was conducted on residents from March to July 2020. We used the nine-item Patient Health Questionnaire (PHQ-9) to determine depression. We use binary logistic regression to evaluate associated factors: loneliness, burnout, sleep quality, Emotional quotients (EQ), and perceived social support (PSS). Results: About one-fifth of residents had depression (47 of 201), 6.97% of students had suicidality. Factors showing a positive correlation with depression included: loneliness (aOR: 1.27; 95%CI: 1.15-1.40); burnout syndrome in depersonalization (aOR: 1.18; 95%CI: 1.10-1.25), and reduced personal accomplishment (aOR: 1.10; 95%CI: 1.05-1.14). Factors showing a negative correlation with depression included: perceived social support from significant others (aOR: 0.91; 95%CI: 0.85-0.98); three subscales of EQ included motivation (aOR: 0.82; 95%CI: 0.68-0.99); life satisfaction (aOR: 0.83; 95%CI: 0.70-0.97); level of peace (aOR: 0.76; 95%CI: 0.66-0.87).Conclusions: Depression in residents was 23.40%. Loneliness, low social support, and burnout (depersonalization, reduced personal accomplishment) were associated with depression. EQ (motivation, life satisfaction, and peace) might reduce depression.
Extreme climatic conditions and effects on cropping activities at a farm settlement in southwestern Nigeria
Authors: Adewoyin Adelowo A , Eludoyin Adebayo Oluwole , Adetoro Olusola Olumide-Ige 
Published: January 2022

Abstract
Mitigating against the impact of extreme climatic conditions is a major concern for many communities in developing countries, especially in the sub-Saharan Africa. This study examined the occurrence of extreme climatic elements and coping strategies of smallholders in a farm community in Nigeria, as well as perception stakeholders in the area on the impact of extreme climatic conditions. Data used were responses of 24 purposively stakeholders and 35 years’ daily rainfall, temperature and wind speed data. Results showed that area experienced rainfall fluctuations as well as temperature increase which were associated with poor germination, impaired of crops growth, alteration of quality harvests and lowered crop productivity in the area. Coping strategies varied with socio-economic differences among the farmers; with the relatively wealthy farmers practicing preventive methods while poor farmers embraced reactive strategies like changing methods of cultivation and praying. The study concluded that food security in the area as typical of many farm communities in the region, will benefit significantly from local knowledge of the farmers.
Non-Invasive Imaging Modalities for Stem Cells Tracking in Osteoarthritis
Authors: Dortaj Hengameh , Alizadeh Ali Akbar , Azarpira Negar , Tayebi Lobat 
Published: January 2022

Abstract
The administration of stem cells in regenerative medicine has emerged as a potential treatment option for many diseases. The privation of an impressive cure for joint pathologies such as knee osteoarthritis (OA) has increased concern in stem cell (SC)-based therapies. Many questions remain about the survival and biology of SC after transplantation. Current progression in molecular biology and imaging has accredited winsome non-invasive SC monitoring in living subjects. Over time, these methods have been updated to assess the viability and biology of SC transplantation. The use of nanoparticles has become important in many aspects of SCs tracking. Given that different tracking strategies are being used for clinical trials, it is important to choose the best one. In this review, various imaging methods, which were assimilated to monitor the viability and biology of SC after injection in osteoarthritis, were discussed.
High-throughput sequencing reveals the dominance of Shewanella species in the intestinal microbiota of Barbour’s seahorses (Hippocampus barbouri)
Authors: Ortega Rose Chinly Mae Huerte , Tabugo Sharon Rose M. , Martinez Joey Genevieve T. , Balcázar José L. 
Published: January 2022

Abstract
In this study, taxonomic classification of intestinal microbiota from healthy Barbour’s seahorses (Hippocampus barbouri) was determined as it plays an important role in host nutrition and immunity. Genomic DNA was extracted from the intestinal mucus samples of eleven Barbour’s seahorses, which were subjected to high-throughput sequencing of bacterial 16S rRNA genes targeting V1-V3 regions. The results revealed that the most abundant operational taxonomic units (OTUs) were affiliated to the genus Shewanella. Our findings may provide baseline data for further studies in order to explore the potential implications of intestinal microbiota to seahorses in terms of health status, development, growth, and survival.
Clinical Study of Surgical Management of Olecranon Fractures
Authors: Shivanna Harish Y , S Ananth H , N Santhosh Kumar T 
Published: January 2022

Abstract
BACKGROUND AND OBJECTIVE: Olecranon fractures are one of the most commonly seen orthopaedic injuries in the emergency room. Fractures of the Olecranon process of the Ulna typically occurs as a result of a motor-vehicle or motorcycle accident, a fall, or assault. The accepted management for Olecranon fractures is for Non displaced fractures short immobilization followed by gradually increasing range of motion. When displaced ,Open reduction and internal fixation with k-wires and figure of eight tension band wiring for simple transverse fractures and olecranon hook plate for comminuted fractures The present study is undertaken to evaluate the results of surgical management, the merits and demerits and to asses elbow joint motion and stability after the procedure.MATERIALS AND METHODS: It is a prospective study which was carried out from September 2010 to September 2012 in Bapuji Hospital and Chigateri General Hospital attached toJ.J.M Medical College, Davangere. In this study period of 25 cases of fracture olecranon treated by Tension band wiring with Kirshner wire for Simple transverse fractures and Olecranon hook plate for Communited fracturesRESULTS: In our series, majority of the patients were males, middle aged, with road traffic accident being the commonest mode of injury, Most of the cases were Type II B fractures i.e., oblique and transverse fractures according to Colton’s classification Surgery was performed with in 3.48 average days, Union was noted clinically and radiologically and functional evaluation was done by Mayo elbow performance score. Excellent results was present in 18 patients (72%), 4(16%) good and 3(12%) fair with no poor results.INTERPRETATION /CONCLUSION From the present study it is concluded that the technique of open reduction and internal fixation with Kirschner wires and tension band wiring for simple transverse and oblique fractures and olecranon plate fixation for comminuted fractures are effective means and gold standard technique of treating fractures of olecranon and is based on sound biomechanical principle.
A Biomechanical Study of the Medial Row Tightening on Stability of Single Stitch Suture-Bridge Construct
Authors: Abihssira Sharon , BOUCHE Pierre-Alban , CAMMAS Claire , THIRACHE Clément , NOURISSAT Geoffroy 
Published: January 2022

Abstract
Purpose: To define the more stable knot tightening of a suture-bridge when a single limb is preserved. Methods: Five different sutures were tested : No. 2 Ethibond (Ethicon), Hi-Fi (ConMed Linvatec), Sutblue (SBM), SingleFlat (SBM), Hi-Fi Ribbon (ConMed Linvatec).A Surgeon’s Knot was tied around a 30-mm circumference device, 6 times for each experiment. A single limb was kept to analyze failure modes of the knot.First step was to analyze which of pulling or sliding suture of the construct must be kept preventing failure of the knot.The cutting distance from the knot was evaluated at 1 mm and 4 mm with the suture loops pretensioned to 10 N and fixed to a second row after a 50 N tension load. The more stable construct was found: a single-pull load to100 N and cyclic load (to 50 N for 30 cycles) experiments were conducted to evaluate the impact of cycling on knot loosening.Results: The more stable construct was obtained when the non-post limb was tensioned, and the post-limb was cut at 4 mm (p<0.01). Loop circumference increased after each experiment for all tested sutures, independently of the preserved limb and the cutting distance. Elongation was significant for all tested sutures in all groups. Knot failure mostly occurred by slippage; only with tapes. Conclusions: a suture bridge construct with the non-post limb preserved and the post-limb cut at a 4 mm distance from the knot provides with the best security. Sutures are safer than tapes in suture-bridge.
Aging threatens sustainability of smallholder farming in China
Authors: Gu Baojing , Ren Chenchen , Zhou Xinyue , Wang Chen , Guo Yaolin , Diao Yu , Shen Sisi , Reis Stefan , Li Wanyue , Xu Jianming 
Published: January 2022

Abstract
Rapidly demographic aging substantially affects socioeconomic development 1-4, presents grand challenges for food security and agricultural sustainability 5-8, which have so far not been well understood. Here, by using over 30,000 households survey across China, we show that rural population aging lowers average education level of farmers by 3% (0-11% across different provinces) and reduces farm size by 4% (2-11%) due to land transfer-out and abandonment in 2019. These changes further led to a reduction of agricultural inputs, including fertilizers and machinery, which decrease agricultural output by 4% and labor productivity by 9%. Meanwhile, fertilizer use efficiency is reduced by 3%, while increasing fertilizer-related pollutants emission to the environment. New farming models, such as cooperative farming, tend to have larger farm sizes and being operated by younger farmers, who have a higher average education level, hence reducing total labor requirement. Without policy interventions, agricultural output, labor productivity and fertilizer use efficiency would decrease by 3-16% as a consequence of population aging by 2100, compared to 2019 levels. With policy measures, such as new farming models, this decrease could be reversed and in fact an increase by approximately one-third achieved in the same time period. Our analyses suggest that population aging effects on agriculture could be effectively addressed through labor saving in large-scale new farming models, further contributing to a widespread transformation of smallholder farming to sustainable agriculture in China.
Spatial Coherence Patterns of Extreme Winter Precipitation In The United States
Authors: Banerjee Abhirup , Kemter Matthias , Goswami Bedartha , Merz Bruno , Kurths Jürgen , Marwan Norbert 
Published: January 2022

Abstract
Extreme precipitation events have a significant impact on life and property. The United States experiences huge economic losses due to severe floods caused by extreme precipitation. With the varied terrain, it becomes increasingly important to understand the spatial variability of extreme precipitation to conduct a proper risk assessment of natural hazards such as floods. In this work, we use a complex network based approach to identify distinct regions exhibiting spatially coherent precipitation patterns due to various underlying climate mechanisms. To quantify interactions between event series of different locations, we use a nonlinear similarity measure, called the edit-distance method, which considers not only the occurrence of the extreme events but also their intensity while measuring similarity. Using network measures, namely, degree and betweenness centrality, we are able to identify the specific regions affected by landfall of atmospheric rivers in addition to those regions where the extreme precipitation due to storm track activity is modulated by different mountain ranges such as the Rockies and the Appalachians. Our approach provides a comprehensive picture of the spatial patterns of extreme winter precipitation in the United States due to various climate processes despite its vast complex topography
Theoretical study on the nature of Gold-X(IVA) interaction
Authors: Xinying Li , Zhang Wanli 
Published: January 2022

Abstract
Structures, stabilities, and interactions of AuX (X = C − Pb) series are theoretically investigated at CCSD(T) and B3LYP levels with extend basis sets. Natural bond orbital analysis shows that the Au-X interaction is resulted by the overlap of sp hybrid on X and 6s5d hybrid on Au atom. Laplacian and total electronic energy density values at BCP shows the “intermediate type” of Au-X (X = Si, Ge, Sn, Pb) interactions and covalent type of Au-C interaction. Moreover, analysis of electron density deformation shows pronounced charge accumulation in the middle of the region between lighter X and Au, suggesting obvious covalent character of interaction. ELF shows increased covalency from X = Pb to X = C. Energy decomposition analysis shows positive steric contribution and negative quantum contributions to the Au-X interactions. Comparing the interaction energy of AuC with other AuX series, the decrease of interaction strength between them is caused by the positive contribution of steric effect and the negative contribution of quantum and electrostatic effects. And steric energy is correlated positively with the total interaction energy and correlated positively with the steric charge deformation at BCP.