bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social capital and health outcomes among older adults in India: a multilevel analysis
Authors: Jyoti Jyoti , Singh S.P. , Malik Manzoor Ahmad 
Published: September 2022

Purpose
The social capital theory is increasingly being looked at as a valuable paradigm to understand if community socioeconomic factors influence health behaviours and outcomes. This requires an understanding of the forms in which social capital manifests and the levels at which it operates.

Design/methodology/approach
Thus, the purpose of this paper is to study if social capital is associated with health outcomes among older adults in India and providing an estimate of the extent to which the neighbourhood differences in health outcomes among the older adults can be attributed to social capital.

Findings
The authors find several forms of social capital to be associated with health outcomes among older adults. The results show that community-level social capital variables collectively explain 12.81% unexplained neighbourhood variation in self-rated health, 2.5% variation in psychological well-being and 11.32% variation in the ability to perform activities of daily living, respectively.

Originality/value
The findings highlight the role social capital plays in serving as a coping mechanism for older adults to survive deteriorating health and social exclusion and call for conscious investment in building social capital.
HigherpHis associated with enhanced co‐occurrence network complexity, stability and nutrient cycling functions in the rice rhizosphere microbiome
Authors: Guo Yaping , Song Bin , Li Anqi , Wu Qi , Huang Haili , Li Na , Yang Ying , Adams Jonathan Miles , Yang Lin 
Published: September 2022

AbstractThe rice rhizosphere microbiota is crucial for crop yields and nutrient use efficiency. However, little is known about how co‐occurrence patterns, keystone taxa and functional gene assemblages relate to soil pH in the rice rhizosphere soils. Using shotgun metagenome analysis, the rice rhizosphere microbiome was investigated across 28 rice fields in east‐central China. At higher pH sites, the taxonomic co‐occurrence network of rhizosphere soils was more complex and compact, as defined by higher average degree, graph density and complexity. Network stability was greatest at medium pH (6.5 < pH < 7.5), followed by high pH (7.5 < pH). Keystone taxa were more abundant at higher pH and correlated significantly with key ecosystem functions. Overall functional genes involved in C, N, P and S cycling were at a higher relative abundance in higher pH rhizosphere soils, excepting C degradation genes (e.g. key genes involved in starch, cellulose, chitin and lignin degradation). Our results suggest that the rice rhizosphere soil microbial network is more complex and stable at higher pH, possibly indicating increased efficiency of nutrient cycling. These observations may indicate routes towards more efficient soil management and understanding of the potential effects of soil acidification on the rice rhizosphere system.
Voting for bureaucracy? Contestation, suffrage and meritocracy
Authors: ANDERSEN DAVID , CORNELL AGNES 
Published: September 2022

AbstractThe relationship between democracy and bureaucracy is the object of both classic and contemporary studies in political science. In classic works, scholars argue that there is an inherent conflict between democracy and bureaucracy, whereas contemporary scholars often assert that democracy is positively related to the development of bureaucracy. We argue that both classic and recent interpretations of the relationship are too simplistic since the two dimensions of democracy, contestation and inclusiveness, are likely to affect bureaucratic development in different ways. On the one hand, electoral contestation strengthens bureaucracy if voters demand public goods that politicians cater to by employing meritocratic recruitment. On the other hand, we cannot take for granted that all voters demand public goods. As poorer people are enfranchised, popular demands for particularistic goods increase, which incentivizes politicians to keep a patrimonial state administration, thus facilitating clientelistic linkages with the electorate. Based on new and improved data on electoral contestation and meritocratic recruitment and a measure of male suffrage, we examine the separate and combined effects of contestation and suffrage on meritocracy worldwide from 1790 to 2012. We find that contestation is positively related to meritocracy after the advent of World War II when universal suffrage and contested elections were generally introduced simultaneously. Before World War II, when suffrage was limited and only gradually extended to poorer segments, contestation is significantly related to meritocracy only at lower levels of suffrage.
The finch in the coal mine: Interrogating the environmental politics of extinction narratives
Authors: Hine Amelia , Mayes Robyn , Hurst Bree 
Published: September 2022

AbstractThe black‐throated finch is an endangered species whose highest quality remaining habitat directly overlaps with the site of the controversial Adani Carmichael coal mine in Central Queensland, Australia. The image of this finch has been widely used by anti‐Adani protest groups as a powerful symbol for the destructive nature of greenfield coal mining. Drawing on extinction studies literature, we problematise the use of the black‐throated finch as a symbol of imminent extinction, highlighting how activists have constructed a fixed finch on‐the‐brink ontology that narrows possible futures for the species. We identify how the finch has been strategically deployed as an affective tool for engaging publics while the anti‐Adani campaign has been primarily driven by concerns around climate change futures. We use primary sources of anti‐Adani ephemera as well as interviews with key scientists, activists, and image‐makers involved in the debate about the Carmichael coal mine. We argue that critical evaluation of the effects and potential consequences of simplified environmental activist narratives and the instrumentalisation of nonhumans is needed to support and enable activism that centres care and responsibility within multispecies entanglements. Engagement with the complexities of environmental intervention in relation to the finch, and not exclusively the mine, is also necessary to locate openings through which more‐than‐human futures can be creatively imagined and enacted.
Proteomic analysis reveals the mechanism of green regulation in garlic puree induced by purple light stress
Authors: Fan Gongjian , He Yi , Kou Xiaohong , Dou Jinfeng , Li Tingting , Wu Caie , Zhu Jinpeng 
Published: September 2022

AbstractGreening is an undesirable appearance in garlic puree during processing. Our previous study indicated that purple light could induce the greening changes in garlic. In order to investigate the mechanism of green regulation in garlic puree, purple light‐induced greening and nongreening garlic puree were used as materials to investigate the differentially expressed proteins (DEPs) by sodium dodecyl‐sulfate polyacrylamide gel electrophoresis and data‐independent acquisition (DIA) technology. The results showed that a total of 186 DEPs were detected by DIA, with 73 DEPs were up‐regulated in greening garlic puree and 113 of them were down‐regulated in greening garlic puree. Most DEPs were belonged to 20 functional categories, and mainly participated in post‐translational modification and transport of proteins, molecular chaperones (12.93%) and signal transduction mechanisms (10.20%), energy production and transformation (6.80%), carbohydrate transport and metabolism (5.44%) and amino acid transport and metabolism (4.08%), indicating that the biological metabolic pathway, metabolic direction, and metabolic strength efficiency significantly changed in garlic puree after greening. Besides, the physiological and biochemical experiments showed that purple light significantly induced the γ‐glutathione transpeptidase activity and prompted the conversion of thiosulfinate into garlic green pigment. This study explained the general molecular mechanism of greening changes of garlic puree in response to purple light.Practical ApplicationGreening is an undesirable appearance in garlic puree during processing, which deteriorate the qualities of garlic. This study provides a comprehensive understanding of green regulation in garlic puree based on proteomics analysis.
Chromosome‐level assembly of Culex pipiens molestus and improved reference genome of Culex pipiens pallens (Culicidae, Diptera)
Authors: Liu Wenjuan , Cheng Peng , An Sha , Zhang Kexin , Gong Maoqing , Zhang Zhong , Zhang Ruiling 
Published: September 2022

AbstractCulex pipiens molestus and Culex pipiens pallens are two distinct bioforms in the Culex pipiens complex that are important vectors of several pathogens and are widely distributed around the world. In the current study, we present a high‐quality chromosome‐level genome of Cx. pipiens f. molestus and describe the genetic characteristics of this genome. The assembly genome was 559.749 Mb with contig and scaffold N50 values of 200.952 Mb and 0.370 Mb, and more than 94.78% of the assembled bases were located on 3 chromosomes. A total of 19,399 protein‐coding genes were predicted. Many gene families were expanded in the genome of Cx. pipiens f. molestus, particularly those of the chemosensory protein (CSP) and gustatory receptor (GR) gene families. In addition, utilizing Hi‐C data, we improved the previously assembled draft genome of Cx. pipiens f. pallens, with scaffold N50 of 186.195 Mb and contig N50 of 0.749 Mb, and more than 97.02% of the assembled bases were located on three chromosomes. This reference genome provides a foundation for genome‐based investigations of the unique ecological and evolutionary characteristics of Cx. pipiens f. molestus, and the findings in this study will help to elucidate the mechanisms involved in species divergence in the Culex pipiens complex.
Jian Pi Shen Shi formula alleviates hyperuricemia and related renal fibrosis in uricase‐deficient rats via suppression of the collagen‐binding pathway
Authors: Yin Na , Li Xiaosi , Liu Weichao , Qi Yan , Wu Runfang , Li Zhaofu , Ying Sai , Yang Haihao , Gu Qianlan , Wu Zhao , Zou Nanting , Duan Weigang , Peng Jiangyun , Wan Chunping 
Published: September 2022

AbstractAimJian Pi Shen Shi Formula (JPSSF) is a beneficial treatment for hyperuricemia and related tissue damage in the clinical setting. This study was designed to investigate its therapeutic potential and underlying mechanisms in uricase‐deficient rats (Uox−/− rats).MethodsUox−/− rats were used to assess the therapeutic potential of JPSSF on hyperuricemia. Protein extracts from renal tissues of a Uox−/− group and a JPSSF group were analyzed using tandem mass tag labeling quantitative proteomic workflow. Collagen deposition in Uox−/− rat kidneys was analyzed by Masson trichromatic staining. The gene expression associated with collagen‐binding‐related signaling pathways in the kidneys was further explored using quantitative polymerase chain reaction assay. The protein expressions of collagen 1a1 (col1a1), col6a1, and α‐smooth muscle actin were measured by Western blotting and immunohistochemistry.ResultsJPSSF significantly decreased renal function indices and alleviated renal injuries. The action of JPSSF was manifested by down‐regulation of col6a1 and interleukin‐1 receptor‐associated kinase‐like 2, which blocked the binding sites on collagen and further prevented kidney injury. The anti‐renal fibrosis effect of JPSSF was confirmed by reducing the collagen deposition and hydroxyproline concentrations. JPSSF treatment also intensely down‐regulated the mRNA and protein expressions of col6a1, col1a1, and α‐smooth muscle actin, which inhibited the function of the collagen‐binding‐related signaling pathway.ConclusionOur results indicated that JPSSF notably ameliorated hyperuricemia and related renal fibrosis in Uox−/− rats through lowering uric acid and down‐regulating the function of the collagen‐binding pathway. This suggested that JPSSF is a potential empirical formula for treating hyperuricemia and accompanying renal fibrosis.
Cost‐effectiveness analysis of silver diamine fluoride to divert dental general anaesthesia compared to standard care
Authors: Nguyen TM , Tonmukayakul U , Hall M , Calache H 
Published: September 2022

AbstractBackgroundThe aim is to perform a model‐based cost‐effectiveness analysis of a silver diamine fluoride (SDF) protocol intervention to divert dental general anaesthesia (DGA) among Victorian children aged 2–10 years.MethodsData inputs were based on an Australian single‐cohort 2017/18 study. Intervention costs for standard care were derived from two subgroups of children: (1) children who received standard care without DGA, and (2) children who received standard care with DGA. Two scenarios were modelled due to limited post‐follow‐up data: (1) children receiving SDF had standard care without DGA (base‐case scenario), and (2) children receiving SDF did not receive standard care without DGA (alternative scenario). A simple decision‐tree model with probabilistic sensitivity analysis (PSA) estimated the incremental costs per diverted DGA.ResultsThe probability of children requiring specialist referral and offered SDF, but the primary carer opted for DGA is 0.124 (SD 0.034), and the probability of children requiring DGA in standard care is 0.346 (SD 0.036). For both the base‐case and alternative scenario, the incremental cost‐effectiveness ratio outcome is dominant and their cost‐effectiveness being either 74.8% or 100% respectively.ConclusionsThe SDF protocol intervention is cost‐effective dental caries management option for young children where referral for DGA is considered. © 2022 Australian Dental Association.
Effects of chemotherapy dose reductions in overweight patients with acute myeloid leukaemia: A Danish nationwide cohort study
Authors: Kristensen Daniel Tuyet , Nielsen Lars Børty , Jakobsen Lasse Hjort Kyneb , Kristensen Tove‐Christina Choe , Jepsen Lene Østergaard , Schöllkopf Claudia , Theilgaard‐Mönch Kim , El‐Galaly Tarec Christoffer , Roug Anne Stidsholt , Severinsen Marianne Tang 
Published: September 2022

SummaryOverweight patients with cancer are frequently reduced in chemotherapy dose due to toxicity concerns, although previous studies have indicated that dose reduction (DR) of overweight patients results in comparable toxicity but may compromise overall survival (OS). Current evidence regarding DR in patients with acute myeloid leukaemia (AML) is limited. To investigate the association between DR and outcome among overweight patients with AML we analysed a Danish nationwide cohort of overweight adult AML patients treated with remission induction chemotherapy. Among 536 patients identified, 10.1% were categorized as DR defined as 95% or less of full body surface area (BSA)‐based dose. Risk factors for DR were high body mass index (BMI) and BSA, therapy‐related AML and favourable cytogenetics. No significant differences were observed for rates of complete remission (CR), 30‐ and 90‐day mortality between DR and non‐DR patients. Furthermore, DR did not affect median relapse‐free survival (RFS) [DR, 14.5 (95% confidence interval, 9.0–41.7) months; non‐DR, 15.0 (12.3–19.3)] with an adjusted difference in five‐year restricted mean survival time (Δ5y‐RMST) of 0.2 (−8.4 to 8.8) months nor median OS (DR, 17.0 [11.9 to 45.5] months; non‐DR, 17.5 [14.8 to 20.5]) with an adjusted Δ5y‐RMST of 0.8 (−5.7 to 7.3) months. In conclusion, we found no statistically significant association between DR and outcomes among overweight patients with AML. However, we acknowledge the limited sample size and encourage further studies in this important subject.
When open data closes the door: A critical examination of the past, present and the potential future for open data guidelines in journals
Authors: Prosser Annayah M. B. , Hamshaw Richard J. T. , Meyer Johanna , Bagnall Ralph , Blackwood Leda , Huysamen Monique , Jordan Abbie , Vasileiou Konstantina , Walter Zoe 
Published: September 2022

AbstractOpening data promises to improve research rigour and democratize knowledge production. But it also presents practical, theoretical, and ethical considerations for qualitative researchers in particular. Discussion about open data in qualitative social psychology predates the replication crisis. However, the nuances of this ongoing discussion have not been translated into current journal guidelines on open data. In this article, we summarize ongoing debates about open data from qualitative perspectives, and through a content analysis of 261 journals we establish the state of current journal policies for open data in the domain of social psychology. We critically discuss how current common expectations for open data may not be adequate for establishing qualitative rigour, can introduce ethical challenges, and may place those who wish to use qualitative approaches at a disadvantage in peer review and publication processes. We advise that future open data guidelines should aim to reflect the nuance of arguments surrounding data sharing in qualitative research, and move away from a universal “one‐size‐fits‐all” approach to data sharing. This article outlines the past, present, and the potential future of open data guidelines in social‐psychological journals. We conclude by offering recommendations for how journals might more inclusively consider the use of open data in qualitative methods, whilst recognizing and allowing space for the diverse perspectives, needs, and contexts of all forms of social‐psychological research.
Ordinal state‐trait regression for intensive longitudinal data
Authors: Osei Prince P. , Reiss Philip T. 
Published: September 2022

AbstractIn many psychological studies, in particular those conducted by experience sampling, mental states are measured repeatedly for each participant. Such a design allows for regression models that separate between‐ from within‐person, or trait‐like from state‐like, components of association between two variables. But these models are typically designed for continuous variables, whereas mental state variables are most often measured on an ordinal scale. In this paper we develop a model for disaggregating between‐ from within‐person effects of one ordinal variable on another. As in standard ordinal regression, our model posits a continuous latent response whose value determines the observed response. We allow the latent response to depend nonlinearly on the trait and state variables, but impose a novel penalty that shrinks the fit towards a linear model on the latent scale.A simulation study shows that this penalization approach is effective at finding a middle ground between an overly restrictive linear model and an overfitted nonlinear model. The proposed method is illustrated with an application to data from the experience sampling study ofBaumeister et al. (2020,Personality and Social Psychology Bulletin, 46, 1631).
Repurposing nitazoxanide as a novel anti‐atherosclerotic drug based on mitochondrial uncoupling mechanisms
Authors: Ma Ming‐Hui , Li Feng‐Feng , Li Wen‐Feng , Zhao Hui , Jiang Man , Yu Yuan‐Yuan , Dong Yan‐Chao , Zhang Yi‐Xin , Li Ping , Bu Wen‐Jie , Sun Zhi‐Jie , Dong De‐Li 
Published: September 2022

Background and PurposeThe anthelmintic drug nitazoxanide has a mitochondrial uncoupling effect. Mitochondrial uncouplers have been proven to inhibit smooth muscle cell proliferation and migration, inhibit NLRP3 inflammasome activation of macrophages and improve dyslipidaemia. Therefore, we aimed to demonstrate that nitazoxanide would protect against atherosclerosis.Experimental ApproachThe mitochondrial oxygen consumption of cells was measured by using the high‐resolution respirometry system, Oxygraph‐2K. The proliferation and migration of A10 cells were measured by using Edu immunofluorescence staining, wound‐induced migration and the Boyden chamber assay. Protein levels were measured by using the western blot technique. ApoE (−/−) mice were fed with a Western diet to establish an atherosclerotic model in vivo.Key ResultsThe in vitro experiments showed that nitazoxanide and tizoxanide had a mitochondrial uncoupling effect and activated cellular AMPK. Nitazoxanide and tizoxanide inhibited serum‐ and PDGF‐induced proliferation and migration of A10 cells. Nitazoxanide and tizoxanide inhibited NLRP3 inflammasome activation in RAW264.7 macrophages, the mechanism by which involved the AMPK/IκBα/NF‐κB pathway. Nitazoxanide and tizoxanide also induced autophagy in A10 cells and RAW264.7 macrophages. The in vivo experiments demonstrated that oral administration of nitazoxanide reduced the increase in serum IL‐1β and IL‐6 levels and suppressed atherosclerosis in Western diet‐fed ApoE (−/−) mice.Conclusion and ImplicationsNitazoxanide inhibits the formation of atherosclerotic plaques in ApoE (−/−) mice fed on a Western diet. In view of nitazoxanide being an antiprotozoal drug already approved by the FDA, we propose it as a novel anti‐atherosclerotic drug with clinical translational potential.
Hsa‐microRNA‐370‐3p targeting Snail and Twist1 suppresses IL‐8/STAT3‐driven hepatocellular carcinoma metastasis
Authors: Peng Siqi , Chen Yutong , Li Ting , Mao Junjie , Yang Pengfei , Zou Baojia , Luo Lisi , Zhang Weiyu , Wang Wen , Xie Rongzhi , Li Jian , Zeng Linjuan 
Published: September 2022

AbstractThe pro‐inflammatory factor interleukin‐8 (IL‐8) is related to poor prognosis in hepatocellular carcinoma (HCC) patients. Interleukin‐8 enhanced HCC invasion by upregulating Snail and Twist1, whether this modulation relies on microRNAs (miR) is unclear. In this study, hsa‐miR‐370‐3p was screened as candidate miRNA targeting Snail and Twist1, and its expression was downregulated by IL‐8. Luciferase assays and RNA electrophoretic mobility shift assays were used to evaluate the interaction between miR‐370‐3p and targeted mRNAs. Coimmunoprecipitation, luciferase, and ChIP assays were undertaken to investigate the mechanisms underlying IL‐8‐mediated modification of miR‐370‐3p. Gain‐ and loss‐of‐function studies, Transwell assays, and a xenograft nude mouse model were used to investigate pro‐ and antitumor activities. Interleukin‐8 and miR‐370‐3p levels were analyzed for clinical relevance in HCC patients. Our results showed that HCC patients with high levels of IL‐8 experienced more metastasis and shorter survival. Interleukin‐8 induced epithelial–mesenchymal transition and promoted liver cancer cell migration, invasion, and metastasis both in vitro and in vivo. MicroRNA‐370‐3p interacted with its cognate mRNA within the 3′‐UTR regions of Twist1 and Snail mRNA directly and specifically and attenuated IL‐8 protumoral effects on liver cancer cells. Interleukin‐8 negatively modulated miR‐370‐3p through signal transducer and activator of transcription 3 (STAT3) activation by recruiting histone deacetylase 1 (HDAC1) to miR‐370‐3p promoter. The STAT3 and HDAC antagonists inhibited liver cancer cell migration and invasion. Patients with high miR‐370‐3p and low IL‐8 levels had longer overall survival. In conclusion, our study elucidated a novel axis IL‐8/STAT3/miR‐370‐3p/Twist1 and Snail relying on HDAC1 recruitment, which showed both diagnostic and therapeutic potentials of miR‐370‐3p in HCC metastasis.