bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Zn2+-triggered two-step mechanism of CLIC1 membrane insertion and activation into chloride channels
Authors: Varela Lorena , Hendry Alex C. , Cassar Joseph , Martin-Escolano Ruben , Cantoni Diego , Ossa Felipe , Edwards John C. , Abdul-Salam Vahitha , Ortega-Roldan Jose L. 
Published: July 2022

ABSTRACT
The chloride intracellular channel (CLIC) protein family displays the unique feature of altering its structure from a soluble form to a membrane-bound chloride channel. CLIC1, a member of this family, is found in the cytoplasm or in internal and plasma membranes, with membrane relocalisation linked to endothelial disfunction, tumour proliferation and metastasis. The molecular switch promoting CLIC1 activation remains under investigation. Here, cellular Cl− efflux assays and immunofluorescence microscopy studies have identified intracellular Zn2+ release as the trigger for CLIC1 activation and membrane insertion. Biophysical assays confirmed specific binding to Zn2+, inducing membrane association and enhancing Cl− efflux in a pH-dependent manner. Together, our results identify a two-step mechanism with Zn2+ binding as the molecular switch promoting CLIC1 membrane insertion, followed by pH-mediated activation of Cl− efflux.
Translation and preliminary validation of the Modified Mini Mental State [3MS] in a Greek sample
Authors: Lyrakos Georgios N , Nikolaidou Georgia , Alizioti Apostolia , Matsota Paraskevi 
Published: July 2022

Background: The Modified Mini Mental State (3MS) is the extended version of the original Mini Mental State test with additional items improving the coverage of the remaining cognitive functions of the original version.
Aim: The aim of this pilot study is to translate the Modified Mini Mental State test and assess its psychometric properties, in order to enable the use of 3MS test for Greek speakers.
Method and Material: Independent sample t-test analysis was performed to test for differences between the study groups (N=105) and dependent sample (N=37), while pair sample t-test for pre-post differences in the treatment group for the 3MS.
Results: Cronbach’s a was 0.867 showing very good internal consistency. Children in the cases group presented significantly lower scores after the tonsil operation as compared to controls revealing good discriminant validity of the measurement. Finally, test-retest scores were shown to be significantly correlated, revealing excellent test-retest reliability of the measurement.
Conclusions: The reliability and validity of the 3MS test is established for the healthy children undergoing routine surgery population.
Teoria demokracji a polaryzacja. Czy spolaryzowane społeczeństwo może być demokratyczne?
Authors: Horonziak Sonia 
Published: July 2022

THEORY OF DEMOCRACY AND POLITICAL POLARIZATION: CAN A POLARIZED SOCIETY REMAINS DEMOCRATIC?
Polarization is a totalizing political tool. While the us versus them division has long fueled political competition, polarization is taking systemic struggle to the next level. Polarization divides the political landscape into two camps, where a compromise can only be found within a given group. The political scene in 21st century Europe is polarized. However, how does this situation affect European values and democratic principles of the rule of law, which protect the stability of democratic systems? Is a polarized state a place where citizens can fully enjoy the benefits of democracy? Can a polarized society reconcile political conflict with democratic values? The article analyzes the phenomenon of political polarization in theoretical terms related to the democratic principles, both classical and those of the contemporary liberal democracies. At the same time, using the example of Poland and other countries, the effects of polarizing actions and their impact on the internal political scene and the social situation are shown.
Susceptibility status of the wild-caught Phlebotomus argentipes (Diptera: Psychodidae: Phlebotominae), the sand fly vector of visceral leishmaniasis, to different insecticides in Nepal
Authors: Roy Lalita , Uranw Surendra , Cloots Kristien , Smekens Tom , Kiran Usha , Pyakurel Uttam Raj , Das Murari Lal , S. Yadav Rajpal , Van Bortel Wim 
Published: July 2022

BackgroundVisceral leishmaniasis (VL) is targeted for elimination as a public health problem in Nepal by 2023. For nearly three decades, the core vector control intervention in Nepal has been indoor residual spraying (IRS) with pyrethroids. Considering the long-term use of pyrethroids and the possible development of resistance in the vectorPhlebotomus argentipessand flies, we monitored the susceptibility status of their field populations to the insecticides of different classes, in villages with and without IRS activities in recent years.Methodology/Principal findingsSand flies were collected from villages with and without IRS in five VL endemic districts from August 2019 to November 2020. The WHO susceptibility test procedure was adopted using filter papers impregnated at the discriminating concentrations of insecticides of the following classes: pyrethroids (alpha-cypermethrin 0.05%, deltamethrin 0.05%, and lambda-cyhalothrin 0.05%), carbamates (bendiocarb 0.1%) and organophosphates (malathion 5%). Pyrethroid resistance intensity bioassays with papers impregnated with 5× of the discriminating concentrations, piperonyl butoxide (PBO) synergist-pyrethroid bioassays, and DDT cross-resistance bioassays were also performed. In the IRS villages, the vector sand flies were resistant (mortality rate <90%) to alpha-cypermethrin and possibly resistant (mortality rate 90–97%) to deltamethrin and lambda-cyhalothrin, while susceptibility to these insecticides was variable in the non-IRS villages. The vector was fully susceptible to bendiocarb and malathion in all villages. A delayed knockdown time (KDT50) with pyrethroids was observed in all villages. The pyrethroid resistance intensity was low, and the susceptibility improved at 5× of the discriminating concentrations. Enhanced pyrethroid susceptibility after pre-exposure to PBO and the DDT-pyrethroid cross-resistance were evident.Conclusions/SignificanceOur investigation showed thatP.argentipessand flies have emerged with pyrethroid resistance, suggesting the need to switch to alternative classes of insecticides such as organophosphates for IRS. We strongly recommend the regular and systematic monitoring of insecticide resistance in sand flies to optimize the efficiency of vector control interventions to sustain VL elimination efforts in Nepal.
The burden of T. solium cysticercosis and selected neuropsychiatric disorders in Mocuba district, Zambézia province, Mozambique
Authors: Langa Irene , Padama Fernando , Nhancupe Noémia , Pondja Alberto , Hlashwayo Delfina , Gouveia Lidia , Stelzle Dominik , da Costa Clarissa Prazeres , Schmidt Veronika , Winkler Andrea S. , Noormahomed Emília Virgínia 
Published: July 2022

BackgroundTaenia solium(neuro-)cysticercosis, a neglected tropical disease, can be associated with epileptic seizures and other neuropsychiatric (= neurological and psychiatric) disorders. This study aimed to evaluate the association ofT. soliumcysticercosis with selected neuropsychiatric disorders and/or symptoms (chronic headache, epileptic seizures/epilepsy and psychosis) in Mocuba district, Mozambique.MethodologyBetween March and May 2018, a cross-sectional study was conducted among 1,086 participants aged 2 years or above in Mocuba district, Zambézia province, central Mozambique, to assess the seroprevalence of human cysticercosis and risk factors for infection, as well as to explore its relation to selected neuropsychiatric disorders. Socio-demographic and clinical data were collected from each participant using a modified questionnaire designed by the Cysticercosis Working Group for Eastern and Southern Africa. Additionally, neuropsychiatric disorders, such as chronic headache, epileptic seizures/epilepsy and psychosis were assessed using four vignettes.T.soliumantigen and cysticercosis IgG in serum were detected using bothT.soliumantigen B158/B60 enzyme linked immunosorbent assay (ELISA) and LDBIO Cysticercosis Western Blot, respectively.Principal findingsOverall, 112/1,086 participants (10.3%) were sero-positive forT.soliumantigen or antibodies. Prevalence of antibodies (6.6%; n = 72) was higher than of antigens (4.9%; n = 54). In the questionnaires, 530 (49.5%) of participants reported chronic headache, 293 (27%) had generalized epileptic seizures, 188 (18%) focal seizures and 183 (18.3%) psychosis. We found a statistically significant association between seropositivity forT.soliumand chronic headache (p = 0.013). Additionally, increasing age (p = 0.03) was associated with Ag-ELISA seropositivity.ConclusionsOur study revealed that in Mocuba,T.soliumcysticercosis is prevalent and associated with self-reported chronic headache. Additionally, in the study setting, the seroprevalence of cysticercosis increased with age. However, it is not associated with other neuropsychiatric disorders such epileptic seizures/epilepsy and psychosis. Future studies are needed to confirm the high burden of neuropsychiatric disorders and their possible etiology, including neurocysticercosis, using additional serological, molecular biological and radiological diagnostic tools, as well as in-depth clinical examinations.
Antiphospholipid antibodies and vitamin D deficiency in COVID-19 infection with and without venous or arterial thrombosis: A pilot case-control study
Authors: Shah Ruchi , Mohammed Yaqub Nadeem , Koehler Tracy J. , Kaur Jasmeet , Toufeili Margarita , Pulipati Priyanjali , Alqaysi Ahmed , Khan Ali , Khalid Mahrukh , Lee Yi , Dhillon Parveen , Dan Anna Thao , Kumar Nicholas , Bowen Monica , Sule Anupam A. , Krishnamoorthy Geetha 
Published: July 2022

Background
Coronavirus disease-2019 (COVID-19) is associated with thromboembolism. Antiphospholipid antibody (APLa) formation is one of the mechanisms. Vitamin D deficiency has been associated with thrombosis in antiphospholipid antibody syndrome.

Objective
Measure APLa and vitamin D in hospitalized COVID-19 patients with and without thrombosis to evaluate if thromboembolism is associated with concomitant APLa and vitamin D deficiency.

Methods
Case-control study. Hospitalized COVID-19 patients with a thromboembolic event (ischemic stroke, myocardial infarction, deep venous thrombosis/pulmonary embolism, Cases n = 20). Controls (n = 20): Age, sex-matched without thromboembolic events. Patients with autoimmune disorders, antiphospholipid antibody syndrome, thrombophilia, anticoagulation therapy, prior thromboembolism, chronic kidney disease 3b, 4, end-stage renal disease, and malignancy were excluded. Given the limited current literature on the role of concomitant antiphospholipid antibodies and vitamin D deficiency in causing venous and/or arterial thrombosis in hospitalized COVID-19 patients, we enrolled 20 patients in each arm. Anti-cardiolipin IgG/IgM, beta-2 glycoprotein-1 IgG/IgM, lupus anticoagulant and vitamin D levels were measured in both groups.

Results
Cases were 5.7 times more likely to be vitamin D deficient (OR:5.7, 95% CI:1.3–25.6) and 7.4 times more likely to have any one APLa (OR:7.4, 95% CI: 1.6–49.5) while accounting for the effects of sex. Patients with both APLa and vitamin D deficiency had significantly more thrombosis compared to patients who were antibody positive without vitamin D deficiency (100% vs 47.4%; p = 0.01).

Conclusions
Thrombosis in COVID-19 was associated with concomitant APLa and vitamin D deficiency. Future studies in COVID-19 should assess the role of vitamin D in reducing thrombosis.
Health care professionals’ experiences of screening immigrant mothers for postpartum depression–a qualitative systematic review
Authors: Skoog Malin , Hallström Inger Kristensson , Vilhelmsson Andreas 
Published: July 2022

Introduction
Postpartum depression is considered a major public health problem, which immigrant mothers are at particular risk of being affected by, but it can also have long-lasting traumatic effects on the child’s health and development. The Edinburgh Postnatal Depression Scale is the world’s most commonly employed screening instrument for postpartum depression, used in connection with a clinical interview to screen for symptoms of postpartum depression. The aim of this study was to synthesize health care professionals (HCPs) experiences of identifying signs of postpartum depression and performing screening on immigrant mothers, since previous research suggested that this task might be challenging.

Methods
The databases CINAHL, PubMed, PsycINFO, SocINDEX, Embase and Cochrane were searched for papers published January 2000–December 2020, reporting qualitative data on immigrants, postpartum depression and the Edinburgh Postnatal Depression Scale. Eight papers representing eight studies from four countries were included and the Critical Appraisal Skills Program was used to assess their quality. The synthesis of studies was guided by Noblit & Hare’s seven-step method based on meta-ethnography.

Findings
The synthesis resulted in two final themes: “I do my best, but I doubt that it’s enough” and “I can find no way forward”. The themes convey the fear and frustration that health care professionals experienced; fear of missing mothers with signs of postpartum depression, related to feeling uncomfortable in the cross-cultural setting and frustration in handling difficulties associated with communication, translated versions of the Edinburgh Postnatal Depression Scale and cultural implications of postpartum depression.

Conclusions and clinical implication
By supporting HCPs’ self-efficacy in handling cultural implications of postpartum depression and by developing evidence-based clinical guidelines for the use of interpreters and translated versions of the Edinburgh Postnatal Depression Scale the screening of immigrant mothers may be facilitated.
Follow-up lung ultrasound to monitor lung failure in COVID-19 ICU patients
Authors: Barnikel Michaela , Alig Annabel Helga Sophie , Anton Sofia , Arenz Lukas , Bendz Henriette , Fraccaroli Alessia , Götschke Jeremias , Vornhülz Marlies , Plohmann Philipp , Weiglein Tobias , Stemmler Hans Joachim , Stecher Stephanie-Susanne 
Published: July 2022

Objectives
Point-of-care lung ultrasound (LU) is an established tool in the first assessment of patients with coronavirus disease (COVID-19). To assess the progression or regression of respiratory failure in critically ill patients with COVID-19 on Intensive Care Unit (ICU) by using LU.

Materials and methods
We analyzed all patients admitted to Internal Intensive Care Unit, Ludwig-Maximilians-University (LMU) of Munich, from March 2020 to December 2020 suffering lung failure caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). LU was performed according to a standardized protocol at baseline and at follow up every other day for the first 15 days using a lung ultrasound score (LUSS). Ventilation data were collected simultaneously.

Results
Our study included 42 patients. At admission to ICU, 19 of them (45%) were mechanically ventilated. Of the non-invasive ventilated ones (n = 23, 55%), eleven patients required invasive ventilation over the course. While LUS did not differ at admission to ICU between the invasive ventilated ones (at baseline or during ICU stay) compared to the non-invasive ventilated ones (12±4 vs 11±2 points, p = 0.2497), LUS was significantly lower at d7 for those, who had no need for invasive ventilation over the course (13±5 vs 7±4 points, p = 0.0046). Median time of invasive ventilation counted 18 days; the 90-day mortality was 24% (n = 10) in our cohort. In case of increasing LUS between day 1 (d1) and day 7 (d7), 92% (n = 12/13) required invasive ventilation, while it was 57% (n = 10/17) in case of decreasing LUS. At d7 we found significant correlation between LU and FiO2 (Pearson 0.591; p = 0.033), p/F ratio (Pearson -0.723; p = 0.005), PEEP (Pearson 0.495; p = 0.043), pplat (Pearson 0.617; p = 0.008) and compliance (Pearson -0.572; p = 0.016).

Conclusion
LUS can be a useful tool in monitoring of progression and regression of respiratory failure and in indicating intubation in patients with COVID-19 in the ICU.
Ventilator-associated pneumonia is linked to a worse prognosis than community-acquired pneumonia in children
Authors: Hernandez-Garcia Maria , Girona-Alarcon Monica , Bobillo-Perez Sara , Urrea-Ayala Mireia , Sole-Ribalta Anna , Balaguer Mònica , Cambra Francisco-José , Jordan Iolanda 
Published: July 2022

Background
Around 12–20% of patients with community-acquired pneumonia (CAP) require critical care. Ventilator-associated pneumonia (VAP) is the second cause of nosocomial infection in Paediatric Intensive Care Units (PICU). As far as we know, there are no studies comparing both types of pneumonia in children, thus it remains unclear if there are differences between them in terms of severity and outcomes.

Objective
The aim was to compare clinical and microbiological characteristics and outcomes of patients with severe CAP and VAP.

Methods
A retrospective descriptive study, including patients diagnosed of VAP and CAP, with a positive respiratory culture and under mechanical ventilation, admitted to the PICU from 2015 to 2019.

Results
238 patients were included; 163 (68.4%) with CAP, and 75 (31.5%) with VAP. Patients with VAP needed longer mechanical ventilation (14 vs. 7 days, p<0.001) and more inotropic support (49.3 vs. 30.7%, p = 0.006). Patients with VAP had higher mortality (12 vs. 2.5%, p = 0.005).
Enterobacterales were more involved with VAP than with CAP (48 vs. 9%, p<0.001). Taking into account only the non-drug sensitive microorganisms, patients with VAP tended to have more multidrug-resistant bacteria (30 vs. 10.8%, p = 0.141) than patients with CAP.

Conclusion
Patients with VAP had worse prognosis than patients with CAP, needing longer mechanical ventilation, more inotropic support and had higher mortality. Patients with VAP were mainly infected by Enterobacterales and had more multidrug resistant microorganisms than patients with CAP.
Association between simultaneity of health-risk behaviours and self-rated health in Brazilian adolescents
Authors: Bandeira Alexsandra da Silva , Del Duca Giovani Firpo , Delevatti Rodrigo Sudatti , Manta Sofia Wolker , Silveira Pablo Magno , Leonel Larissa dos Santos , Rezende Leandro F. M. , Silva Kelly Samara 
Published: July 2022

Introduction
This study examined the association between simultaneity of four health-risk behaviours, namely, low levels of moderate-to-vigorous physical activity (insufficient MVPA: <420 min/week), tobacco use, alcohol consumption, and excessive television (TV)–(>2 h/d of TV viewing) and self-rated health (SRH) in Brazilian adolescents.

Methods
We used data of 100,551 adolescents from the National School Health Survey, a national cross-sectional study carried out in 2015. Association between simultaneity of health risk behaviours (i.e. the ratio between observed and expected prevalence rates) and SRH was examined using logistic regression models.

Results
The majority of the participants were female (51.9%) and 14 years of age (50.6%), and 26% of the participants’ SRH ranged from ’average’ to ’extremely poor’. Those who engaged in the following combinations of health-risk behaviours had higher odds of worse SRH than their healthier counterparts: insufficient MVPA and tobacco use (odds ratio—OR: 2.0, 95% confidence interval [CI]: 1.4 to 3.0); insufficient MVPA and alcohol consumption (OR: 1.6, 95%CI: 1.3 to 1.9); insufficient MVPA and >2 h/day of TV viewing (OR: 1.3, 95%CI: 1.1 to 1.6); insufficient MVPA, tobacco use and alcohol consumption (OR: 2.1, 95%CI: 1.7, to 2.7); and insufficient MVPA, alcohol consumption and >2 h/day of TV viewing (OR: 1.6, 95%CI: 1.4 to 2.0).

Conclusions
Insufficient MVPA, alcohol consumption, and other health-risk behaviours were associated with worse SRH in Brazilian adolescents.
African Luxury: Aesthetics and Politics, Mehita Iqani and Simidele Dosekun (eds) (2019)
Authors: Mullins Jacqueline F. 
Published: July 2022

Review of: African Luxury: Aesthetics and Politics, Mehita Iqani and Simidele Dosekun (eds) (2019)
Bristol: Intellect Ltd., 180 pp.,
ISBN 978-1-78320-993-4, h/bk, $33.00
THE EFFECT OF MAT PILATES IN LUMBAR FLEXIBILITY OF OVERWEIGHT AND OBESE CHILDREN
Authors: Hartono Graciela Eunike , Koesoema Tanti Ajoe , Isma AP Rahmi , Anantyo Dimas Tri 
Published: July 2022

Background : Overweight and obesity are the conditions where lumbar have to bear more load, and it will decrease its flexibility. Decrease of lumbar flexibility will affect the range of motion. Based on some literatures, mat pilates will increase the ability on lumbar flexibility, however there is no evidence effect of mat pilates in children, especially overweight and obese children. Aim : To know the effect of mat pilates on lumbar flexibility of overweight and obese children. Method :This study was pre experimental one group pre and post test design with 20 subjects based on inclusion dan exclusion criteria. Subjects did mat Pilates exercise for 12 times. Lumbar flexibility was measured by Modified Modified Schober Test for lumbal flexion and extension before intervention and after 4 weeks mat pilates exercise. Data analyzed by SPSS using Saphiro Wilk test as data’s nomalities test and Paired T test as hypothesis test. Result : The mean of MMST Flexion pre and post test after Mat Pilates have increased from 3,15±0,3118 cm to 7,63±0,4 cm. The mean of MMST extension pre and post test after Mat Pilates hav e increased from 1,415±0,21 cm to 3±0,236 cm. The means of a BMI Post test (24,89 ± 0,9 kg/m2) is higher than the mean of a BMI Pre test (24,86 ± 0,8 kg/m2).The significant result proves the effect of mat pilates in lumbar flexibility of overweight and obese children which measured by MMST Flexion and MMST Extension. The result of p value for MMST Flexion is p=0,00 and the result of p value for MMST Extension is p=0,00 which both of MMST flexion and Extension are significant or different. Conclusion : Mat pilates can increase the lumbar flexibility of overweight and obese children.Keyword: Mat Pilates, Lumbar Flexibility, overweight and obese children.
Zur Konzeption einer Religionslinguistik
Authors: Liebert Wolf-Andreas 
Published: July 2022

Zusammenfassung
Es wird eine religionslinguistische Konzeption dargestellt, mit der Sprache nicht nur in monotheistischen Religionen, sondern auch in den weniger bekannten Formen, insbesondere in losen Netzwerkstrukturen, in Formen des Atheismus und Agnostizismus sowie »säkularen« Bereichen wie Sport, Wissenschaft, Wirtschaft oder Politik untersucht werden kann. Dazu werden die Konzepte der exzentrischen Positionalität Helmuth Plessners und der Unbedingtheit Ulrich Barths religionslinguistisch verknüpft, um daraus einen Begriff von religiöser Erfahrung zu gewinnen. Religion erscheint dann als kulturelle Praxis mit der Funktion, mit diesen religiösen Erfahrungen produktiv umzugehen. Mit einem linguistischen Sprachbegriff, der die sechs Aspekte Strukturen, Ereignisse, Praktiken, Artefakte, Figuren und Diskurse enthält, kann eine dreidimensionale Matrix aus religiöser Erfahrung, Funktion und Sprache gewonnen werden, die als Heuristik für den Dialog zwischen Theologie und Linguistik verstanden wird, aber auch als Grundlage für die erwähnten anderen Formen im religiösen Bereich oder den angesprochenen säkularen Bereichen wie der Politik dienen kann.