bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the transition capability of the low-voltage wind turbine in the sub-synchronous state using a fuzzy controller
Authors: Dwijendra Ngakan Ketut Acwin , Jalil Abduladheem Turki , Abed Azher M , Bashar Bashar S , Al-Nussairi Ahmed Kateb Jumaah , Hammid Ali Thaeer , Shamel Ali , Uktamov Khusniddin Fakhriddinovich 
Published: August 2022

Abstract
The main problem of wind turbines is associated with induction generators in their power supply during short circuits in the grid. In this research, a new method is presented for the uninterrupted operation of a wind turbine equipped with an induction generator fed on both sides of feeding during network errors. Wind farms equipped with a doubly-fed induction generator (DFIG) require two abilities to allow system operators to increase proficiency. These capabilities include fault ride-through and synchronization of output force fluctuations, especially when these generators generate significant electrical power. A MATLAB® software environment has been used to evaluate and improve the performance of these turbines. A fuzzy complement (FC) controller is used to improve the performance of the DFIG. The results demonstrate that this controller limits the operation of the turbine current and voltage in the short-circuit mode well. Regarding results obtained from comparing two different modes, it can be said that ripple is 4% in the FC mode, while this parameter is equal to 10% for the proportional-integral controller.
Regional variation in tolvaptan prescribing across England: national data and retrospective evaluation from an expert centre
Authors: Chong Jiehan , Harris Tess , Ong Albert C M 
Published: August 2022

ABSTRACT

Background
Tolvaptan, a vasopressin V2 receptor antagonist, was approved in 2015 by the UK National Institute for Health and Care Excellence for use in patients with autosomal dominant polycystic kidney disease (ADPKD) and rapid disease progression. Simultaneous guidance was issued by the UK Kidney Association (UKKA) to facilitate national implementation.

Methods
Data on tolvaptan prescribing in England was obtained through the National Health Service (NHS) Digital, a national survey of all 77 adult kidney units, and the implementation of UKKA guidance was evaluated at an expert PKD centre.

Results
A regional variation of up to 4-fold for tolvaptan prescribing in England was found. Despite most kidney units following UKKA guidance, centre-based estimates of eligible or treated patient numbers were highly variable. Retrospective evaluation at an expert PKD centre revealed that in a cohort demonstrating rapid estimated glomerular filtration rate (eGFR) decline, 14% would not be eligible for tolvaptan by Mayo imaging classification and more than half (57%) would not be eligible by Predicting Renal Outcome in Polycystic Kidney Disease score. The 3-year discontinuation rate was higher than expected (56%), the majority (70%) due to aquaretic symptoms. In patients taking tolvaptan for at least 2 years, 81% showed a reduction in the rate of eGFR decline compared with baseline, with earlier disease associated with positive treatment response.

Conclusion
Real-world data have revealed a much higher regional variation in tolvaptan prescribing for ADPKD in England than expected. We propose further investigation into the factors responsible for this variation.
Pushed Northward by Climate Change: Range Shifts With a Chance of Co-occurrence Reshuffling in the Forecast for Northern European Odonates
Authors: Pélissié Mathieu , Johansson Frank , Hyseni Chaz 
Published: August 2022

AbstractBiodiversity is heavily influenced by ongoing climate change, which often results in species undergoing range shifts, either poleward or uphill. Range shifts can occur provided suitable habitats exist within reach. However, poleward latitudinal shifts might be limited by additional abiotic or biotic constraints, such as increased seasonality, photoperiod patterns, and species interactions. To gain insight into the dynamics of insect range shifts at high latitudes, we constructed ecological niche models (ENMs) for 57 Odonata species occurring in northern Europe. We used citizen science data from Sweden and present-day climatic variables covering a latitudinal range of 1,575 km. Then, to measure changes in range and interactions among Odonata species, we projected the ENMs up to the year 2080. We also estimated potential changes in species interactions using niche overlap and co-occurrence patterns. We found that most Odonata species are predicted to expand their range northward. The average latitudinal shift is expected to reach 1.83 and 3.25 km y−1 under RCP4.5 and RCP8.5 scenarios, respectively, by 2061–2080. While the most warm-dwelling species may increase their range, our results indicate that cold-dwelling species will experience range contractions. The present-day niche overlap patterns among species will remain largely the same in the future. However, our results predict changes in co-occurrence patterns, with many species pairs showing increased co-occurrence, while others will no longer co-occur because of the range contractions. In sum, our ENM results suggest that species assemblages of Odonata—and perhaps insects in general—in northern latitudes will experience great compositional changes.
Predictive value of post-percutaneous coronary intervention fractional flow reserve: a systematic review and meta-analysis
Authors: Andersen Birgitte Krogsgaard , Ding Daixin , Mogensen Lone Juul Hune , Tu Shengxian , Holm Niels Ramsing , Westra Jelmer , Wijns William 
Published: August 2022

AbstractAimsWe aimed to investigate the relationship between post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) and clinical outcome using a systematic review with a study-level meta-analysis.Methods and resultsMEDLINE, Embase, and CENTRAL were systematically searched for articles with clinical follow-up reporting mean or median final post-PCI FFR. The main outcome was a composite of major adverse cardiac events (MACE) including all-cause death, myocardial infarction (MI), and target vessel revascularization (TVR). Meta-regression analyses were performed on mean post-PCI FFR values. A total of 62 studies with 12 340 patients and 12 923 stented vessels were included, with follow-ups ranging from 1 to 89 months. Post-PCI FFR was not continuously associated with the rate of 1-year MACE or 1-year TVR using meta-regression models accounting for heterogeneous follow-up lengths. For studies comparing high vs. low post-PCI FFR, low post-PCI FFR was associated with high risk ratio for MACE {1.97 [95% confidence interval (CI):1.45–2.67]}, all-cause death [1.59 (95% CI: 1.08–2.34)], MI [3.18 (95% CI: 1.84–5.50)], TVR [2.08 (95% CI: 1.63–2.65)] and angina status [2.50 (95% CI: 1.53–4.06)] using different optimal cut-off values spanning from 0.80 to 0.95.ConclusionWe found no clear continuous association between post-PCI FFR and clinical outcomes in this systematic study-level meta-analysis. In a subset of studies investigating binary classification, high post-PCI FFR was associated with a better clinical outcome than low post-PCI FFR.We investigated the relationship between post-percutaneous coronary intervention (PCI) fractional flow reserve (FFR) and rate of major adverse cardiac events (MACE), including all-cause death, myocardial infarction (MI), and target vessel revascularization (TVR), using a systematic review and study-level meta-analysis, pooling 12 340 patients from 62 studies. Mean post-PCI FFR was not continuously associated with a 1-year MACE rate accounting for heterogenous follow-up lengths. Still, the risk ratio favoured high post-PCI FFR for reduced MACE, all-cause death, MI, TVR, and better angina status using different cut-offs.
Identification and Parametric Estimation of Empirical Dynamic Marriage Matching Models
Authors: Chen Liang , Choo Eugene 
Published: August 2022

Abstract
Marriage matching markets typically involve heterogenous agents participating in a dynamic, non-stationary environment. These features pose a considerable modelling challenge. In this paper, we develop a new parametric model of dynamic marriage that allows for market non-stationarity using a system of transitionary equilibria. We propose a method to identify and parametrically estimate the model by representing the model equilibrium with a fixed-point mapping. We apply our model to investigate how China’s one-child policy has affected the marriage distribution through its effect on the population and sex ratios.
Incidental coronary calcium in cancer patients treated with anthracycline and/or trastuzumab
Authors: Hooks Matthew , Sandhu Gurmandeep , Maganti Tejaswini , Chen Ko-Hsuan Amy , Wang Michelle , Cullen Ryan , Velangi Pratik S , Gu Christina , Wiederin Jason , Connett John , Brown Roland , Blaes Anne , Shenoy Chetan , Nijjar Prabhjot S 
Published: August 2022

Abstract

Aims
Cancer patients are at increased risk of cardiovascular disease (CVD) after treatment with potentially cardiotoxic treatments. Many cancer patients undergo non-gated chest computed tomography (NCCT) for cancer staging prior to treatment. We aimed to assess whether coronary artery calcification on NCCT predicts CVD risk in cancer patients.

Methods and results
Six hundred and three patients (mean age: 61.3 years, 30.8% male) with either breast cancer, lymphoma, or sarcoma were identified retrospectively. Primary endpoint was a major adverse cardiac event (MACE) composite including non-fatal myocardial infarction, new heart failure (HF) diagnosis, HF hospitalization, and cardiac death, with Fine-Gray analysis for non-cardiac death as competing risk. Secondary endpoints included a coronary composite and a HF composite. Coronary artery calcification was present in 194 (32.2%) and clinically reported in 85 (43.8%) patients. At a median follow-up of 5.3 years, 256 (42.5%) patients died of non-cardiac causes. Coronary artery calcification presence or extent was not an independent predictor of MACE [sub-distribution hazards ratio (SHR) 1.28; 0.73–2.27]. Coronary artery calcification extent was a significant predictor of the coronary composite outcome (SHR per two-fold increase 1.14; 1.01–1.28), but not of the HF composite outcome (SHR per two-fold increase 1.04; 0.95–1.14).

Conclusion
Coronary artery calcification detected incidentally on NCCT scans in cancer patients is prevalent and often not reported. Coronary artery calcification presence or extent did not independently predict MACE. Coronary artery calcification extent was independently associated with increased risk of CAD events but not HF events.
Infection by a eukaryotic gut parasite in wild Daphnia sp. associates with a distinct bacterial community
Authors: Rajarajan Amruta , Wolinska Justyna , Walser Jean-Claude , Mäder Minea , Spaak Piet 
Published: August 2022

Abstract
Host-associated bacterial communities play an important role in host fitness and resistance to diseases. Yet, few studies have investigated tripartite interaction between a host, parasite and host-associated bacterial communities in natural settings. Here, we use 16S rRNA gene amplicon sequencing to compare gut- and body- bacterial communities of wild water fleas belonging to the Daphnia longispina complex, between uninfected hosts and those infected with the common and virulent eukaryotic gut parasite Caullerya mesnili (Family: Ichthyosporea). We report community-level changes in host-associated bacteria with the presence of the parasite infection; namely decreased alpha diversity and increased beta diversity at the site of infection, i.e. host gut (but not host body). We also report decreased abundance of bacterial taxa proposed elsewhere to be beneficial for the host, and an appearance of taxa specifically associated with infected hosts. Our study highlights the host-microbiota-infection link in a natural system and raises questions about the role of host-associated microbiota in natural disease epidemics as well as the functional roles of bacteria specifically associated with infected hosts.
Intensification of Implementation Strategies: Developing a Model of Foundational and Enhanced Implementation Approaches to Support National Adoption and Scale-up
Authors: Hughes Jaime M , Zullig Leah L , Choate Ashley L , Decosimo Kasey P , Wang Virginia , Van Houtven Courtney H , Allen Kelli D , Nicole Hastings S 
Published: August 2022

AbstractImplementation strategies are activities to support integration of evidence-based programs (EBPs) into routine care. Comprised of 170+ facilities, the Veterans Affairs Healthcare System is conducive to evaluating feasibility and scalability of implementation strategies on a national level. In previous work evaluating implementation of three EBPs for older Veterans (hospital-based walking, caregiver skills training, group physical therapy), we found facilities varied in their need for implementation support, with some needing minimal guidance and others requiring intensive support. Committed to national scalability, our team developed an implementation intensification model consisting of foundational (low-touch) and enhanced (high-touch) implementation support. This Forum article describes our multilevel and multistep process to develop and evaluate implementation intensification. Steps included (a) review completed trial data; (b) conduct listening sessions; (c) review literature; (d) draft foundational and enhanced implementation support packages; (e) iteratively refine packages; and (7) devise an evaluation plan. Our model of implementation intensification may be relevant to other health care systems seeking strategies that can adapt to diverse delivery settings, optimize resources, help build capacity, and ultimately enhance implementation outcomes. As more health care systems focus on spread of EBPs into routine care, identifying scalable and effective implementation strategies will be critical.
Quantitative trait locus (xQTL) approaches identify risk genes and drug targets from human non-coding genomes
Authors: Bykova Marina , Hou Yuan , Eng Charis , Cheng Feixiong 
Published: August 2022

AbstractAdvances and reduction of costs in various sequencing technologies allow for a closer look at variations present in the non-coding regions of the human genome. Correlating non-coding variants with large-scale multi-omic data holds the promise not only of a better understanding of likely causal connections between non-coding DNA and expression of traits but also identifying potential disease-modifying medicines. Genome–phenome association studies have created large datasets of DNA variants that are associated with multiple traits or diseases, such as Alzheimer’s disease; yet, the functional consequences of variants, in particular of non-coding variants, remain largely unknown. Recent advances in functional genomics and computational approaches have led to the identification of potential roles of DNA variants, such as various quantitative trait locus (xQTL) techniques. Multi-omic assays and analytic approaches toward xQTL have identified links between genetic loci and human transcriptomic, epigenomic, proteomic and metabolomic data. In this review, we first discuss the recent development of xQTL from multi-omic findings. We then highlight multimodal analysis of xQTL and genetic data for identification of risk genes and drug targets using Alzheimer’s disease as an example. We finally discuss challenges and future research directions (e.g. artificial intelligence) for annotation of non-coding variants in complex diseases.
Dominantly acting KIF5B variants with pleiotropic cellular consequences cause variable clinical phenotypes
Authors: Flex Elisabetta , Albadri Shahad , Radio Francesca Clementina , Cecchetti Serena , Lauri Antonella , Priolo Manuela , Kissopoulos Marta , Carpentieri Giovanna , Fasano Giulia , Venditti Martina , Magliocca Valentina , Bellacchio Emanuele , Welch Carrie L , Colombo Paolo C , Kochav Stephanie M , Chang Richard , Barrick Rebekah , Trivisano Marina , Micalizzi Alessia , Borghi Rossella , Messina Elena , Mancini Cecilia , Pizzi Simone , De Santis Flavia , Rosello Marion , Specchio Nicola , Compagnucci Claudia , McWalter Kirsty , Chung Wendy K , Del Bene Filippo , Tartaglia Marco 
Published: August 2022

Abstract
Kinesins are motor proteins involved in microtubule (MT)-mediated intracellular transport. They contribute to key cellular processes, including intracellular trafficking, organelle dynamics and cell division. Pathogenic variants in kinesin-encoding genes underlie several human diseases characterized by an extremely variable clinical phenotype, ranging from isolated neurodevelopmental/neurodegenerative disorders to syndromic phenotypes belonging to a family of conditions collectively termed as ‘ciliopathies.’ Among kinesins, kinesin-1 is the most abundant MT motor for transport of cargoes towards the plus end of MTs. Three kinesin-1 heavy chain isoforms exist in mammals. Different from KIF5A and KIF5C, which are specifically expressed in neurons and established to cause neurological diseases when mutated, KIF5B is an ubiquitous protein. Three de novo missense KIF5B variants were recently described in four subjects with a syndromic skeletal disorder characterized by kyphomelic dysplasia, hypotonia and DD/ID. Here, we report three dominantly acting KIF5B variants (p.Asn255del, p.Leu498Pro and p.Leu537Pro) resulting in a clinically wide phenotypic spectrum, ranging from dilated cardiomyopathy with adult-onset ophthalmoplegia and progressive skeletal myopathy to a neurodevelopmental condition characterized by severe hypotonia with or without seizures. In vitro and in vivo analyses provide evidence that the identified disease-associated KIF5B variants disrupt lysosomal, autophagosome and mitochondrial organization, and impact cilium biogenesis. All variants, and one of the previously reported missense changes, were shown to affect multiple developmental processes in zebrafish. These findings document pleiotropic consequences of aberrant KIF5B function on development and cell homeostasis, and expand the phenotypic spectrum resulting from altered kinesin-mediated processes.
Clonal hematopoiesis and risk of prostate cancer in large samples of European ancestry men
Authors: Wang Anqi , Xu Yili , Yu Yao , Nead Kevin T , Kim TaeBeom , Xu Keren , Dadaev Tokhir , Saunders Ed , Sheng Xin , Wan Peggy , Pooler Loreall , Xia Lucy Y , Chanock Stephen , Berndt Sonja I , Gapstur Susan M , Stevens Victoria , Albanes Demetrius , Weinstein Stephanie J , Gnanapragasam Vincent , Giles Graham G , Nguyen-Dumont Tu , Milne Roger L , Pomerantz Mark M , Schmidt Julie A , Stopsack Konrad H , Mucci Lorelei A , Catalona William J , Hetrick Kurt N , Doheny Kimberly F , MacInnis Robert J , Southey Melissa C , Eeles Rosalind A , Wiklund Fredrik , Kote-Jarai Zsofia , de Smith Adam J , Conti David V , Huff Chad , Haiman Christopher A , Darst Burcu F 
Published: August 2022

Abstract
Little is known regarding the potential relationship between clonal hematopoiesis (CH) of indeterminate potential (CHIP), which is the expansion of hematopoietic stem cells with somatic mutations, and risk of prostate cancer, the fifth leading cause of cancer death of men worldwide. We evaluated the association of age-related CHIP with overall and aggressive prostate cancer risk in two large whole-exome sequencing studies of 75 047 European ancestry men, including 7663 prostate cancer cases, 2770 of which had aggressive disease, and 3266 men carrying CHIP variants. We found that CHIP, defined by over 50 CHIP genes individually and in aggregate, was not significantly associated with overall (aggregate HR = 0.93, 95% CI = 0.76–1.13, P = 0.46) or aggressive (aggregate OR = 1.14, 95% CI = 0.92–1.41, P = 0.22) prostate cancer risk. CHIP was weakly associated with genetic risk of overall prostate cancer, measured using a polygenic risk score (OR = 1.05 per unit increase, 95% CI = 1.01–1.10, P = 0.01). CHIP was not significantly associated with carrying pathogenic/likely pathogenic/deleterious variants in DNA repair genes, which have previously been found to be associated with aggressive prostate cancer. While findings from this study suggest that CHIP is likely not a risk factor for prostate cancer, it will be important to investigate other types of CH in association with prostate cancer risk.
Aeroallergen-related Diseases Predate the Diagnosis of Inflammatory Bowel Disease
Authors: Alenezy Namarik , Nugent Zoann , Herman Sari , Zaborniak Karver , Ramsey Clare D , Bernstein Charles N 
Published: August 2022

Abstract

Objective
This study aimed to determine whether having a diagnosis of asthma or allergic rhinitis (AR) increased the risk of being diagnosed with inflammatory bowel disease (IBD) and whether there was increased incidence of these diseases after a diagnosis of IBD.

Design
This is a retrospective, historical cohort–based study. We used the administrative data of Manitoba Health and the population-based University of Manitoba IBD Epidemiology Database. We used numbers of prescriptions for drugs used to treat asthma and to treat AR to identify diagnoses of asthma and AR, respectively.
We calculated relative risks (RRs) to assess incidence of IBD compared with matched controls after diagnoses of asthma and AR and hazard ratios to determine the incidence of asthma and AR after IBD diagnosis.

Results
Compared with controls, a diagnosis of asthma or AR preceding a diagnosis of IBD was increased in cases (RR, 1.62; 95% confidence interval [CI], 1.50-1.75; and RR, 2.10; 95% CI, 1.97-2.24) with a similar outcome by subtype of IBD (Crohn’s disease vs ulcerative colitis) and by sex. On sensitivity analysis, diagnoses of asthma or AR were comparable when considering at least 5, 10, 15 or 20 drug prescriptions. Persons with IBD were more likely to develop asthma or AR than controls after being diagnosed with IBD (hazard ratio for asthma, 1.31, 95% CI, 1.18-1.45; and hazard ratio for AR, 2.62, 95% CI, 2.45-2.80).

Conclusions
The association between asthma, AR, and IBD suggest the possibility that whatever triggers the onset of these atopic diseases may trigger the onset of IBD as well, and aeroallergens are plausible culprits.
The Dialectic of the International: Elaborating the Historical Materialism of the Gay Liberationists
Authors: Stoffel Alexander 
Published: August 2022

Abstract
What is the relation between sexuality and the international? The literature on sexuality within international studies demonstrates that a full appreciation of contemporary transformations of sexuality across the globe requires an interrogation of the divisions—West/non-West, North/South, or core/periphery—that characterize our view of the international. While many have studied how the transnational circulation of sexual discourses troubles such divisions, fewer have asked how they came about in the first place. Historical materialism is uniquely instructive in this regard. This methodology expounds the division of the international into distinct spheres as historically constituted and founded on capitalist social relations. Such a methodology can be found within the intellectual writings of the gay liberation movement. Through their fraught relationship with the Cuban government, which represented them as a cultural imperialist offensive against the newly formed Communist state, the gay liberationists developed a dialectical conception of the international that acknowledged the differential constitution of sexual life within specific contexts, yet sought to reveal the international systems of power that produce and regulate those seemingly distinct sexual formations across international divides. Gay liberationism, this article argues, offers us a rich tradition for developing accounts of sexuality within a stratified capitalist world order.