bluuebunny/crossref_metadata_2025_split huggingface dataset:
Промисловий поступ Донбасу за мемуарами іноземців (друга половина ХІХ – початок ХХ ст.)
Authors: Piatnytskova Iryna , Otzemko Olena 
Published: October 2022

Метою статті є дослідження мемуарних свідчень іноземців про Донбас другої половини ХІХ – початку ХХ ст., як прикладу іноземного погляду на регіон часів модернізаційних змін, визначення їхнього інформаційного потенціалу та репрезентативності щодо відтворення історії Донбасу. Дослідницький інтерес зосереджений на території Донеччини.
Наукова новизна статті полягає в аналізі особливостей віддзеркалення промислового поступу Донбасу другої половини ХІХ – початку ХХ ст. в мемуарах іноземців, зважаючи на їхні властивості як джерел особового походження, і як складової іноземної україніки.
Висновки. Аналізовані мемуари іноземців відрізняються за жанром і характером висвітлення подій і процесів на території Донбасу другої половини ХІХ – початку ХХ ст. Їхніми авторами були представники різних країн і професій, які мали відмінну мету перебування в регіоні, а відповідно власний фокус спостереження. Разом з тим для них характерно багато спільних моментів в описанні краю. Автори наголошували на вторинній модернізації в Росії, недостатності внутрішніх причин для промислового поступу та його можливості лише за умови залучення іноземних фахівців. З огляду на це їхню увагу привертали приклади найбільш вдалого промислового розвитку, що були реалізовані шляхом поєднання місцевого ресурсу з досвідом іноземців. Саме цим пояснюється зосередження основної уваги мемуаристів на діяльності «Новоросійського товариства», його підприємствах та Юзівці.
Індустріальний ландшафт робітничого поселення автори порівнюють із світовим досвідом промислових міст, наголошуючи на їхній аналогічності. Зосередженням англійського способу життя автори вважали британську колонію Юзівки. У меншій мірі описано інші промислові поселення регіону. У мемуарах іноземців, через опис життя й умов праці, відтворено складнощі процесу формування робітничої соціально-професіональної групи. Авторам притаманна рефлексія щодо позитивного культурницького впливу іноземців на розвиток регіону.
Залучення матеріалів аналізованих джерел до досліджень історії Донбасу другої половини ХІХ – початку ХХ ст. здатне розширити їхній фактографічний і концептуальний аспект як в інформаційному плані, так і в аспекті формування образу регіону представниками іноземної спільноти.
A novel blood pressure monitoring technique by smart HUAWEI WATCH: A validation study according to the ANSI/AAMI/ISO 81060-2:2018 guidelines
Authors: Wang Lili , Xian Hong , Guo Jiajun , Li Weihao , Wang Jiaqi , Chen Qing , Fu Xiaoyu , Li Hongbao , Chen Qin , Zhang Wei , Chen Yucheng 
Published: October 2022

BackgroundGiven the rapid innovation of wearable technology, additional physical indicators can be detected, and blood pressure (BP) has become the focus of many emerging medical-device manufacturers. This study aimed to validate the accuracy of the newly developed HUAWEI WATCH in BP monitoring, according to the American National Standards Institute/Association for the Advancement of Medical Instrumentation/International Organization for Standardization (ANSI/AAMI/ISO 81060-2:2018) guidelines.Materials and methodsThe same arm sequential BP measurement was applied. One validation included four reference BP measurements taken simultaneously by two independent observers using a mercury sphygmomanometer, alternating with three test-watch measurements. Each test-watch measurement was compared against the average of the previous and subsequent reference BP readings. Two criteria were required for validation: (1) a mean BP difference of 5 mm Hg or less, with a standard deviation (SD) of 8 mm Hg or less for systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the 255 pairs of measurements, and (2) an SD for the of 85 averaged BP differences within the threshold defined by the mean test-reference BP difference listed in the ANSI/AAMI/ISO 81060-2:2018 guidelines.ResultsThe mean age of the 85 participants was 48 ± 18 years (range: 21–85), and 53 (62.4%) were male. The mean differences between the test and reference BPs were -0.25 ± 5.62 mm Hg and -1.33 ± 6.81 mm Hg for SBP and DBP, respectively (according to Criterion 1). The mean differences between the test BPs and reference BPs were -0.25 ± 5.00 mm Hg and -1.33 ± 6.31 mm Hg for SBP and DBP, respectively, according to Criterion 2.ConclusionBlood pressure measurement using the HUAWEI WATCH showed excellent consistency with reference BPs, and fulfilled both validation criteria of the guidelines, show its promise as a wearable device for BP self-monitoring.
Spatiotemporal impact of the COVID-19 pandemic lockdown on air quality pattern in Nanjing, China
Authors: Fei Sun , Wagan Raja Asif , Hasnain Ahmad , Hussain Aamir , Bhatti Uzair Aslam , Elahi Ehsan 
Published: October 2022

In response to the COVID-19 outbreak, severe steps have been taken to control its rapid spread by countries globally. A nationwide lockdown was executed at the end of January 2020 in China, which resulted in a significant change and an improvement in air quality patterns. In this study, the objectives were to assess the spatiotemporal impact of the COVID-19 lockdown on air quality in Nanjing, China. The present study researched the six air pollutant parameters, namely, PM10, PM2.5, SO2, NO2, CO, and O3. The data were divided into six periods, P1–P3: pre-lockdown, during lockdown, and after lockdown periods, P4–P6: 2017–19 (same dates of lockdown). The results reveal that during the COVID-19 control period, a significant drop and an improvement in air quality were observed. According to our findings, the PM10, PM2.5, SO2, NO2, and CO concentrations were reduced by -33.03%, -35.41%, -21.26%, -39.79%, and -20.65%, respectively, while the concentration of O3 significantly increased by an average of 104.85% in Nanjing. From the previous 3 years to lockdown variations, PM10 (-40.60%), PM2.5 (-40.02%), SO2 (-54.19%), NO2 (-33.60%), and CO (23.16%) were also reduced, while O3 increased (10.83%). Moreover, compared with those in the COVID-19 period, the levels of PM10, SO2, NO2, CO, and O3 increased by 2.84%, 28.55%, 4.68%, 16.44%, and 37.36%, respectively, while PM2.5 reduced by up to -14.34% after the lockdown in Nanjing. The outcomes of our study provide a roadmap for the scientific community and local administration to make policies to control air pollution.
A system suitability testing platform for untargeted, high-resolution mass spectrometry
Authors: Dmitrenko Andrei , Reid Michelle , Zamboni Nicola 
Published: October 2022

The broad coverage of untargeted metabolomics poses fundamental challenges for the harmonization of measurements along time, even if they originate from the very same instrument. Internal isotopic standards can hardly cover the chemical complexity of study samples. Therefore, they are insufficient for normalizing data a posteriori as done for targeted metabolomics. Instead, it is crucial to verify instrument’s performance a priori, that is, before samples are injected. Here, we propose a system suitability testing platform for time-of-flight mass spectrometers independent of liquid chromatography. It includes a chemically defined quality control mixture, a fast acquisition method, software for extracting ca. 3,000 numerical features from profile data, and a simple web service for monitoring. We ran a pilot for 21 months and present illustrative results for anomaly detection or learning causal relationships between the spectral features and machine settings. Beyond mere detection of anomalies, our results highlight several future applications such as 1) recommending instrument retuning strategies to achieve desired values of quality indicators, 2) driving preventive maintenance, and 3) using the obtained, detailed spectral features for posterior data harmonization.
Potential use of gold-silver core-shell nanoparticles derived from Garcinia mangostana peel for anticancer compound, protocatechuic acid delivery
Authors: Lee Kar Xin , Shameli Kamyar , Nagao Yuki , Yew Yen Pin , Teow Sin-Yeang , Moeini Hassan 
Published: October 2022

Colorectal cancer is one of the most killing cancers and this has become a global problem. Current treatment and anticancer drugs cannot specifically target the cancerous cells, thus causing toxicity towards surrounding non-cancer cells. Hence, there is an urgent need to discover a more target-specific therapeutic agent to overcome this problem. Core-shell nanoparticles have emerged as good candidate for anticancer treatment. This study aimed to synthesize core-shell nanoparticles via green method which utilised crude peels extract of Garcinia mangostana as reducing and stabilising agents for drug delivery. Gold-silver core-shell nanoparticles (Au-AgNPs) were synthesized through seed germination process in which gold nanoparticles acted as the seed. A complete coating was observed through transmission electron microscopy (TEM) when the ratio of AuNPs and AgNPs was 1:9. The size of Au-AgNPs was 38.22 ± 8.41 nm and was mostly spherical in shape. Plant-based drug, protocatechuic acid (PCA) was loaded on the Au-AgNPs to investigate their anticancer activity. In HCT116 colon cancer cells, PCA-loaded Au-AgNPs (IC50 = 10.78 μg/ml) showed higher inhibitory action than the free PCA (IC50= 148.09 μg/ml) and Au-AgNPs alone (IC50= 24.36 μg/ml). Up to 80% inhibition of HCT116 cells was observed after the treatment of PCA-loaded Au-AgNPs at 15.63 μg/ml. The PCA-loaded Au-AgNPs also showed a better selectivity towards HCT116 compared to CCD112 colon normal cells when tested at the same concentrations. These findings suggest that Au-AgNPs system can be used as a potent nanocarrier to combat cancerous cells by offering additional anticancer properties to the loaded drug.
Narrow ovale foramina may be involved in the development of primary trigeminal neuralgia
Authors: Li Shuo , Liao Chenlong , Qian Meiqiong , Yang Xiaosheng , Zhang Wenchuan 
Published: October 2022

BackgroundThe etiology of primary trigeminal neuralgia remains unclear and is worthy of further study; In this study, the morphometric characteristics of ovale foramina between various groups were compared and analyzed to explore the novel cause of primary trigeminal neuralgia.MethodsHigh-resolution three-dimensional reconstruction images from head computed tomography of 109 patients with primary trigeminal neuralgia affecting the third branch of the trigeminal nerve and 46 healthy controls were retrospectively reviewed. Among the 109 primary trigeminal neuralgia patients, 79 patients with apparent neurovascular compression (not simply contact) demonstrated on MRI or during surgery were divided into the classical trigeminal neuralgia group and 30 patients with MRI showing no significant abnormalities were divided into idiopathic trigeminal neuralgia group. The morphometric parameters including the area, width and length of ovale foramina were examined through the use of radiologic methods.ResultsIn this study, the average minimum area, width and length of 79 ovale foramina on the affected and unaffected sides in the classical trigeminal neuralgia group were 21.83 ± 8.45, 21.94 ± 7.93 mm2, 2.32 ± 0.91, 2.58 ± 0.81, 5.32 ± 1.29, and 5.26 ± 1.21 mm, respectively. No significant difference in these parameters was observed (p &gt; 0.05). However, in the idiopathic trigeminal neuralgia group, the average minimum area, width and length of 30 ovale foramina were 21.33 ± 8.21, 22.85 ± 8.36 mm2, 2.25 ± 0.90, 2.79 ± 0.96, 5.20 ± 1.27, and 5.28 ± 1.19 mm, respectively. The width on the symptomatic side was significantly smaller (p = 0.03) than that on the asymptomatic side. No significant difference in area (p = 0.48) or length (p = 0.79) was observed. In addition, when compared with the healthy control group, the area and width of ovale foramina on the symptomatic side in both groups were significantly smaller. No significant difference in length was observed.ConclusionsBy comparing and analyzing the statistical data, it can be inferred that a narrow foramen ovale is associated with primary trigeminal neuralgia, as well as its recurrence after microvascular decompression.
A non-contrast computed tomography-based radiomics nomogram for the prediction of hematoma expansion in patients with deep ganglionic intracerebral hemorrhage
Authors: Xu Wei , Guo Hongquan , Li Huiping , Dai Qiliang , Song Kangping , Li Fangyi , Zhou Junjie , Yao Jingjiang , Wang Zhen , Liu Xinfeng 
Published: October 2022

Background and purposeHematoma expansion (HE) is a critical event following acute intracerebral hemorrhage (ICH). We aimed to construct a non-contrast computed tomography (NCCT) model combining clinical characteristics, radiological signs, and radiomics features to predict HE in patients with spontaneous ICH and to develop a nomogram to assess the risk of early HE.Materials and methodsWe retrospectively reviewed 388 patients with ICH who underwent initial NCCT within 6 h after onset and follow-up CT within 24 h after initial NCCT, between January 2015 and December 2021. Using the LASSO algorithm or stepwise logistic regression analysis, five models (clinical model, radiological model, clinical-radiological model, radiomics model, and combined model) were developed to predict HE in the training cohort (n = 235) and independently verified in the test cohort (n = 153). The Akaike information criterion (AIC) and the likelihood ratio test (LRT) were used for comparing the goodness of fit of the five models, and the AUC was used to evaluate their ability in discriminating HE. A nomogram was developed based on the model with the best performance.ResultsThe combined model (AIC = 202.599, χ2 = 80.6) was the best fitting model with the lowest AIC and the highest LRT chi-square value compared to the clinical model (AIC = 232.263, χ2 = 46.940), radiological model (AIC = 227.932, χ2 = 51.270), clinical-radiological model (AIC = 212.711, χ2 = 55.490) or radiomics model (AIC = 217.647, χ2 = 57.550). In both cohorts, the nomogram derived from the combined model showed satisfactory discrimination and calibration for predicting HE (AUC = 0.900, sensitivity = 83.87%; AUC = 0.850, sensitivity = 80.10%, respectively).ConclusionThe NCCT-based model combining clinical characteristics, radiological signs, and radiomics features could efficiently discriminate early HE, and the nomogram derived from the combined model, as a non-invasive tool, exhibited satisfactory performance in stratifying HE risks.
Sex differences in apoptosis do not contribute to sex differences in blood pressure or renal T cells in spontaneously hypertensive rats
Authors: Abdelbary Mahmoud , Mohamed Riyaz , Gillis Ellen E. , Diaz-Sanders Karl , Baban Babak , Brands Michael W. , Sullivan Jennifer C. 
Published: October 2022

Apoptosis is a physiological and anti-inflammatory form of cell death that is indispensable for normal physiology and homeostasis. Several studies have reported aberrant activation of apoptosis in various tissues at the onset of hypertension. However, the functional significance of apoptosis during essential hypertension remains largely undefined. The current study was designed to test the hypothesis that apoptosis contributes to sex differences in blood pressure and the T cell profile in spontaneously hypertensive rats (SHR). Apoptosis was measured in kidney, aorta and spleen of 13-week-old adult hypertensive male and female SHR. Female SHR had greater renal and aortic apoptosis compared to age-matched males; apoptosis in the spleen was comparable between the sexes. Based on well-established sex differences in hypertension, we tested the hypothesis that greater apoptosis in female SHR contributes to the lower BP and pro-inflammatory profile compared to males. Male and female SHR were randomized to receive vehicle or ZVAD-FMK, a cell permeable pan-caspase inhibitor, in established hypertension from 13 to 15 weeks of age or at the onset of hypertension from 6 to 12 weeks or age. Treatment with ZVAD-FMK lowered renal apoptosis in both studies, yet neither BP nor renal T cells were altered in either male or female SHR. These results suggest that apoptosis does not contribute to the control or maintenance of BP in male or female SHR or sex differences in renal T cells.
Personal protective equipment (PPE) related adverse skin reactions among healthcare workers at the main COVID-19 isolation center in Barbados
Authors: Bharatha Ambadasu , Krishnamurthy Kandamaran , Cohall Damian , Rahman Sayeeda , Forde Corey A. , Corbin-Harte Rhea , Ojeh Nkemcho , Kabir Russell , Parsa Ali Davod , Rabbi Ahbab Mohammad Fazle , Majumder Md Anwarul Azim 
Published: October 2022

BackgroundThe use of personal protective equipment (PPE) reduces the risk of transmission of infectious agents significantly among healthcare workers (HCWs). The study aimed to investigate the prevalence and characteristics of PPE-related adverse skin reactions among HCWs working at the main COVID-19 isolation center in Barbados.MethodsA cross-sectional web-based online survey was conducted during April to June 2021 which recorded demographic information, details of PPE use and adverse skin reactions including severity and duration of onset of symptoms.ResultsMost of the respondents used PPE for consecutive days (77.9%), 1–6 h/day (59.2%), and more than a year (62.5%). Fewer than half of the participants (45.6%) experienced adverse skin reactions from the use of PPE. The reactions were mostly observed in the cheeks (40.4%) and nose bridges (35.6%). Females had more reactions than their male counterparts (p = 0.003). The use of N95 masks and a combination of surgical and N95 masks produced adverse effects predominantly in the ears (60%) and cheeks (56.4%). Binary logistic regression showed that female HCWs (OR = 5.720 95% CI: 1.631, 20.063), doctors (OR = 5.215 95% CI: 0.877, 31.002), and longer duration of PPE use (&gt;1 year) (OR = 2.902 95% CI: 0.958, 8.787) caused a significantly higher prevalence of adverse skin reactions.ConclusionThe PPE-related skin reactions were common among HCWs which mainly occurred due to prolonged use. Preventive measures inclusive of appropriate training of HCWs on the use of PPE are recommended to minimize these adverse events.
Therapeutic effect of laparoscopic salpingotomy vs. salpingectomy on patients with ectopic pregnancy: A systematic review and meta-analysis
Authors: Wenjing Lin , Haibo Li 
Published: October 2022

Background and aimLaparoscopic treatment of ectopic pregnancy mainly includes laparoscopic salpingotomy and salpingectomy. We aimed to assess the therapeutic effect of laparoscopic salpingotomy and salpingectomy on patients with tubal pregnancy.MethodsFrom January 2000 through June 2022, the Cochrane Library, Medline, PubMed, Web of Science, EMBASE, and the Chinese Biomedicine Database were searched for studies that compared the therapeutic effect of laparoscopic salpingotomy vs. salpingectomy in the treatment of tubal pregnancy.ResultsTwenty-four randomized clinical trials (RCTs) studies were incorporated into this analysis. No statistical differences were found between the two groups in terms of operation duration and postoperative hospitalize length, but the volume of intraoperative blood loss in patients with laparoscopic salpingotomy was less than that in salpingectomy. Importantly, the natural intrauterine pregnancy rate after laparoscopic salpingotomy was significantly higher than those who underwent salpingectomy. In addition, laparoscopic salpingotomy can better protect the ovarian reserve function and endocrine function and provide favorable conditions for the second pregnancy.ConclusionPatients with ectopic tubal pregnancy should give priority to laparoscopic salpingotomy for embryo extraction.
A point source model to represent heat distribution without calculating the Joule heat during radiofrequency ablation
Authors: Mariappan Panchatcharam , B Gangadhara , Flanagan Ronan 
Published: October 2022

Numerous liver cancer oncologists suggest bridging therapies to limit cancer growth until donors are available. Interventional radiology including radiofrequency ablation (RFA) is one such bridging therapy. This locoregional therapy aims to produce an optimal amount of heat to kill cancer cells, where the heat is produced by a radiofrequency (RF) needle. Less experienced Interventional Radiologists (IRs) require a software-assisted smart solution to predict the optimal heat distribution as both overkilling and untreated cancer cells are problematic treatments. Therefore, two of the big three partial differential equations, 1) heat equation (Pennes, Journal of Applied Physiology, 1948, 1, 93–122) to predict the heat distribution and 2) Laplace equation (Prakash, Open Biomed. Eng. J., 2010, 4, 27–38) for electric potential along with different cell death models (O’Neill et al., Ann. Biomed. Eng., 2011, 39, 570–579) are widely used in the last three decades. However, solving two differential equations and a cell death model is computationally expensive when the number of finite compact coverings of a liver topological structure increases in millions. Since the heat source from the Joule losses Qr = σ|∇V|2 is obtained from Laplace equation σΔV = 0, it is called the Joule heat model. The traditional Joule heat model can be replaced by a point source model to obtain the heat source term. The idea behind this model is to solve σΔV = δ0 where δ0 is a Dirac-delta function. Therefore, using the fundamental solution of the Laplace equation (Evans, Partial Differential Equations, 2010) we represent the solution of the Joule heat model using an alternative model called the point source model which is given by the Gaussian distribution.Qrx=∑xi∈Ω1K∑icie−|x−xi|22σ2where K and ci are obtained by using needle parameters. This model is employed in one of our software solutions called RFA Guardian (Voglreiter et al., Sci. Rep., 2018, 8, 787) which predicted the treatment outcome very well for more than 100 patients.
Cat-CVD SiN
x
as a gas barrier for application to perovskite solar cells
Authors: Tu Huynh Thi Cam , Shimazaki Ai , Kaneko Ryuji , Wakamiya Atsushi , Ohdaira Keisuke 
Published: October 2022

Abstract
We investigated a silicon nitride (SiN
x
) film prepared by catalytic chemical vapor deposition as a gas barrier for further improving stability of mixed-cation-halide perovskite (PVK) Cs0.05FA0.85MA0.1PbI2Br under dark air conditions. The SiN
x
film can be formed on the PVK capped with carrier transport layers such as 2,2′,7,7′-tetrakis[N,N-di(4-methoxylphenyl)amino]−9,9′-spirobifluorene (Spiro-OMeTAD) and phenyl-C61-butyric-acid-methyl-ester (PCBM)/aluminum-doped-zinc-oxide (AZO) with less degradation in its optical transmittance property and crystal structure. The PVK/Spiro-OMeTAD encapsulated by SiN
x
exhibits a slower reduction in average carrier lifetime after storage for 330 h at room temperature with ∼65%RH. The PVK/PCBM/AZO covered with SiN
x
shows a small blue-shift (8–10 nm) in the absorption band-edge of PVK and with less decrease in the transmittance in the long wavelength range for ∼500 h at 85 °C with ∼2%RH. These results demonstrate the effect of SiN
x
in preventing the degradation of PVK due to the interactions with moisture and oxygen in the air.