bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary gastric Burkitt’s Lymphoma mimicking gastric cancer: a case report
Authors: Geng Siyi , Chu Yi , Zhou Peng , Zhu Hongyi 
Published: November 2022

Abstract
Burkitt’s Lymphoma is a highly malignant B-cell non-Hodgkin’s lymphoma that is extremely sensitive to intensified chemotherapy and its occurrence is closely associated with Epstein-Barr virus. Extranodal lymphoma often involves the gastrointestinal tract, but primary gastrointestinal lymphoma is rare, and primary gastric Burkitt’s Lymphoma is even rarer. We report a case of upper abdominal distension, eventually diagnosed as primary Burkitt’s Lymphoma of the stomach, including clinical manifestations, diagnosis and treatment. The patient showed favorable treatment response to intensified combination chemotherapy. We evaluate treatment response through endoscopy and radiological tests. This report suggested that primary gastric Burkitt’s Lymphoma is a rare yet treatable disease. The etiology and prognosis of Burkitt’s Lymphoma need to be explored in the future.
Synchronous double primary lung cancer with cystic airspaces: a case report and literature review
Authors: Wang An , Du Yu , Ma Qinyun , Chen Xiaofeng 
Published: November 2022

Abstract
Background: Synchronous double primary lung cancer (SDPLC) is the most common type in multiple primary lung cancer (MPLC), which is a rare type of lung cancer. Lung cancer combined with cystic airspaces is relatively rare in imaging manifestation.
Case presentation: Here, we reported a case with SDPLC which consisted of squamous cell carcinoma and mucinous adenocarcinoma with cystic airspaces. A new solid nodule developed form cystic airspaces in the left lower lung in three months after the right inferior lung cancer radical surgery. Left pleural effusion appeared in two months after the second left inferior lung cancer radical surgery. The patient died of severe immune-related pneumonitis induced by Camrelizumab in the fourth cycle of postoperative treatment.
Conclusion: Synchronous double primary lung cancer with cystic airspaces have never been reported before, and no SMPLC cases with rapidly and poorly prognosis were reported. Therefore, we must pay more attention to the rapid progress of mucinous adenocarcinoma with cystic airspaces.
Retrospective Drug use Evaluation of Ceftriaxone In Resource Limited Setting In Case Of Bedele General Hospital, Ethiopia
Authors: Jifar Wakuma Wakene , Adugna Debisa , Gadisa Bontu , Debele Gebiso Roba , Admasu Tesfaye Tsegaye 
Published: November 2022

Abstract
Background: Anti-microbial resistance (AMR) due to the over use of the reserved antibiotics like ceftriaxone is one of the threatening global issues of public health and many patients suffer due to harms arising from AMR because the infections caused by viruses, bacteria, fungi, protozoa and helminthes are no longer susceptible to the commonly available antibiotics.
Objective: To evaluate the utilization pattern of ceftriaxone at Medical Ward in Bedele General Hospital, Bedele, South West Oromia, Ethiopia.
Methodology: Patients' medical record cards (PMRCs) from the medical ward at Bedele General Hospital who took ceftriaxone between July 1 and December 30 of 2021 were the subject of a hospital-based retrospective cross-sectional study design and the selection of the medical record cards was done using a systemic random sample technique. Utilizing current Ethiopia's Standard Treatment Guideline for General Hospital and Drug Use Evaluation Criteria, the appropriateness of the ceftriaxone usage was assessed.
Results: A total of 212 patients’ medical records were reviewed and the most frequent age group was adults in the range of 18-65 (80.5%) and the use of ceftriaxone was inappropriate in 185 cases (47.1%). Ceftriaxone was mainly used for the treatment of pneumonia condition (46.2%), regarding ceftriaxone dosage in our study, the majority of patients received 2 g/day (85.4%) and the mean duration of ceftriaxone therapy in our study was 11.47 days, with a range of 2-7 days (49.7%). Maintenance fluids were the most commonly co-administered medications with a frequency of 32.9%. Conclusions: Prescribers should follow the national standard treatment guideline in order to increase rational use of ceftriaxone and stop the emergence of resistance. The hospital may choose to implement antimicrobial control systems and short-term training for health care professional in order to adhere the treatment guideline is our recommendation.
Predominant contribution of an endogenous cellulase to the cellulolysis in the digestive system of grub of banana pseudostem weevil, Odoiporus longicollis (Coleoptera: Curculionidae)
Authors: Bhuvaragavan Sreeramulu , Reshma Thenozhiyil , Hilda Karuppiah , Meenakumari Mani , Sru Kannan , Nivetha Ramanathan , Janarthanan Sundaram 
Published: November 2022

Abstract

Insects have evolved with effective strategies to utilize cellulose as energy source by possessing novel cellulolytic enzymes which can be used as an optimal resource in the bioenergy sector. The study was aimed for evaluating the cellulolytic enzyme in the grub gut of banana pseudostem weevil, Odoiporus longicollis Olivier (Coleoptera: Curculionidae). Primarily, cellulase activity was localized in the gut system, in which the midgut showed the highest activity. The optimum temperature and thermo-tolerance of cellulase activity were found to be 60°C, and was stable at a pH between 5 and 6. Various concentrations of divalent cations (CaCl2, MgCl2, and CuCl2) have differential enhancing and inhibitory effects on cellulase activity. The cellulase was purified using anion exchange chromatography. The specific activity of purified cellulase was 1190.46 U mg− 1. The molecular weight of the cellulase was determined to be 47 kDa. The physicochemical parameters of purified enzyme were similar to that of enzyme activity of crude extract. Mass spectrometry results identified this cellulase was of GHF5 family. The gut microbial cellulase activity as exogenous source showed no competence comparatively.
Synthesis of visible light-responsive cuprous oxide/sunflower stem pith hybrid materials for detoxification of methylene blue
Authors: Liu Xiangyao , Zhang Haili , Jing Guolin 
Published: November 2022

Abstract
The detoxification of dye-contaminated water by photocatalysis has become a research priority. Here, a novel hybrid material, cuprous oxide/sunflower stem pith (Cu2O/SSP), was successfully synthesized in situ, using copper hydroxide gel, prepared by ion exchange, as the precursor to Cu2O. The presence of Cu2O nanoparticles on the SSP was confirmed by scanning electron microscopy, Fourier transform infrared spectroscopy and X-ray diffraction analyses. Using methylene blue (MB) as the target pollutant, Cu2O/SSP delivered excellent adsorption–photocatalytic degradation and was readily photoregenerated. Cu2O/SSP removed 72.7% of MB after 60 min under visible light irradiation, an increase of 15.6 % compared with unmodified SSP. SSP plays three roles in the removal of MB: it acts as an adsorbent for the MB, a carrier for the Cu2O nanoparticles and it also inhibits photocorrosion of Cu2O. The mechanism of adsorption–photocatalysis by Cu2O/SSP was investigated and a description of the mechanism is provided. This study paves the way for the detoxification of dye-containing wastewater using hybrid biomass materials.
Concentration-mediated Folding and Unfolding of Collagen Triple Helix
Authors: Sun Xiuxia , Xiao Jianxi , Fu Caihong , Li Wenhua 
Published: November 2022

Background:
Collagen has been widely utilized in tissue engineering, regenerative
medicine and cosmetics. Collagen of low concentrations is frequently applied to reduce the production
cost, while it may result in the loss of triple helical structure and bioactivity. CD and NMR techniques
have enhanced our understanding of collagen triple helix, while they require high concentrations of
collagen samples.

Objective:
We have systematically investigated the folding and unfolding features of collagen mimetic
peptides at a broad variety of concentrations in order to decipher the role of the concentration in the
triple helical stability.

Methods:
Peptide FAM-G(POG)10 was synthesized by the solid phase synthesis method. Fluorescence
spectra of peptide FAM-G(POG)10 at different concentrations were recorded. The unfolding and
folding profiles of peptide FAM-G(POG)10 with concentrations varying from 1 nM to 100 μM were
examined. The effect of concentration on the folding and unfolding capability of peptide FAMG(
POG)10 was investigated.

Results:
Fluorescence characterization of peptide FAM-G(POG)10 under widely varying concentrations
from 1 nM to 100 μM has revealed that concentration played a critical role in the stability of collagen
peptides. The two-phase pattern of the concentration-dependent folding and unfolding curves has for
the first time demonstrated the presence of a critical concentration for the collagen peptide to trigger
the complete folding of the triple helix and to maintain the triple helix structure. It is noteworthy that
the triple helix structure of collagen peptides was very stable at μM-level concentrations from both the
folding and unfolding perspectives.

Conclusion:
It has significantly contributed to our understanding of collagen triple helix stability at
low and ultra-low concentrations, and provided valuable and practical guidelines for the preparation of
collagen-based products.
Imaging Manifestation and Pathological Comparison of the Peritoneal
Loose Body: A Case Report and Review of the Literature
Authors: Li Xiaoran , Wu Hui , Wang Shuwen , Wu Jing , Chen Yu-Chen 
Published: November 2022

Background:
Peritoneal loose body (PLB) which is also called "peritoneal mouse" is a rare
disease, with only a few cases reported. PLB is mostly found due to unplanned examination, surgery,
or autopsy. With the increase in abdominal imaging examinations, it was gradually recognized by us.
The diagnosis of PLB has three major characteristics: free movement, no blood supply, and pathological
exclusion of other tumors.

Case Presentation:
We reported a 66-year-old male patient with an asymptomatic freely moving peritoneal
loose body. The size of the lesion was about 4*4cm. The imaging data were complete including
Ultrasound, Magnetic resonance (MR), Computed tomography (CT) plain scan and enhancement. Interestingly,
changes in the location of the lesion were found on follow-up CT. The lesion showed concentric
circles changes on CT without obvious enhancement. MR also appeared as a multi-layer signal
of concentric circles. In addition, the imaging manifestations were compared with histological pathology
in this article to explain imaging characteristics.

Conclusion:
PLB is an uncommon disease. Through the complete imaging examination of this case,
we can further understand the mobility of the lesion by changing the position. The CT and MR have
characteristic concentric circle changes without obvious enhancement. The diagnosis could be confirmed
before surgery, which prompted the clinical early diagnosis of the disease, and an appropriate
choice between surgery and conservative treatment.
Evaluation of Stress and Strain on Mandible Caused by Using “All-on-Four” System from PEEK in Hybrid Prosthesis: Finite Element Analysis
Authors: Shash Yomna H. , Elwakad Mohamed T. , Eldosoky Mohamed A. A. , Dohiem Mohamed M. 
Published: November 2022

Background
Hybrid prostheses have recently been used to restore the mastication mechanism. These prostheses utilize the “All on four” concept, in which four implants are inserted into the jaw bone and supported by bar. Titanium is usually used in the production of “All on four” parts due to its good mechanical properties, however, it has drawbacks such as aesthetic impairment, casting issues, stress shielding, and incompatibility with imaging techniques. These drawbacks have prompted researchers to find alternative materials (e.g. polymers). Recently, the new polymeric material PEEK, has a major role in dentistry due to its biocompatibility, shock-absorbing ability, and good mechanical and chemical properties. The density of spongy bone is expected to influence the choice of “All on four” material.

Objective
This work used the finite element method to conduct stress /strain analysis on a mandible rehabilitated with a hybrid prosthesis, by using PEEK in the production of “All on four” parts instead of titanium, using different densities of spongy bone.

Methods
3D mandibular model with a hybrid prosthesis was constructed, then “All on four” parts were stimulated with titanium and PEEK materials under different mastication mechanisms.

Results
PEEK material reduced the stresses and strains on bone tissues and increased the mucosal stress compared to titanium. Consequently, this material was recommended to be used in producing “All on four” parts, especially in the low-density model.

Conclusions
The density of spongy bone influenced the choice of “All on four” material. Moreover, further researches on PEEK implants and abutments are required in near future.
The Relevance of Human Cytomegalovirus and Epstein-Barr Virus infections in Febrile Neutropenic Patients with Hematological Malignancy
Authors: Mohammed Ahmed Hasan 
Published: November 2022

Background:
viral infections are commonly detected in the patients with neutropenia and hematological malignancies. Human Cytomegalovirus (HCMV) and Epstein-Barr Virus (EBV) are reported in the association with many types of hematological malignancies and they have clinical relevance in the febrile neutropenia.

Patients and Methods:
Fifty patients with febrile neutropenia and hematological malignancies whether receiving prophylaxis antibiotic and chemotherapy treatment or not have been enrolled in this study. Blood sample was collected for viral DNA extraction, then conventional PCR and gel electrophoresis were performed to detect HCMV and EBV DNA in the patient’s samples.

Results:
Acute Myeloid Leukemia is the most leukemic type 25 (50%) of hematological malignancies. There was no association between the presence of HCMV and EBV DNA and febrile neutropenia and the results showed presence of 1 sample positive from 50 sample (2%) for each of HCMV and EBV.

Conclusion:
Although small percentage of patients in the current study showed positive finding for HCMV and EBV DNA, but this does not diminish the importance of further studies to look for the role of these viruses and the investigation of other viruses that can increase the disease burden at patients with febrile neutropenia and hematological malignancies.
Molecular Study of Class1 and 2 Integrons in Methicillin-resistant Staphylococcus Aureus
Authors: Zaki Maysaa El Sayed , Faried Osama Ahmed , Montaseer Karim 
Published: November 2022

Background and Aim:
Methicillin-Resistant Staphylococcus aureus (MRSA) had appeared in the last few decades and became a significant health problem. The study aimed to evaluate the prevalence of class 1 and class 2 integrons among MRSA clinical isolates from different healthcare-associated infections (HAIs) and the prevalence of multi-drug resistance (MDR) in these isolates.

Materials and Methods:
Two hundred Staphylococcus aureus (S. aureus) isolates from different HAIs were evaluated for the presence of the mecA gene, class 1 (intI1) and class 2 (intI2) integrons via the polymerase chain reaction (PCR) beside the determination of antibiotics sensitivity.

Results:
MRSA was determined by resistance to cefoxitin in 152 isolates (76%) of isolated S. aureus. The molecular study showed the prevalence of mecA, intI1, and intI2 genes among the isolated MRSA strains as follows: 100%, 70.4%, 13.1, respectively, and there were 12 isolates (7.9%) that had both intI1 and intI2 genes. There was a significant high incidence of resistance to gentamicin (P=0.01), amikacin (P=0.005), tobramycin (P=0.035), erythromycin (P=0.035), clindamycin (P=0.08), levofloxacin (P=0.0001) and ciprofloxacin (P=0.0001) in MRSA strains positive for intI1 and/or intI2 genes compared to MRSA strains negative for intI genes and non-methicillin resistant S. aureus (Non- MRSA) strains. There was a significantly high prevalence of MDR among MRSA strains positive for intI1 and/or intI2 genes (62.8%) compared to MRSA strains negative for intI genes (28.8%) and Non- MRSA strains (8.3%), (P=0.0001).

Conclusion:
The present study revealed a high prevalence of MRSA strains among S. aureus clinical isolates with a high prevalence of the mecA gene in those isolates. There was also a high prevalence of intI1gene but not intI2 gene. The mecA and intI genes were associated with the development of MDR in S. aureus.
Self-management Strategies for Patients with Risk Factors to Reduce the Impact of Cardiovascular Disease in Selected Clinics in Limpopo Province, South Africa
Authors: MN Kgatla , Mothiba TM , RN Malema , Makgahlela M , Sodi T 
Published: November 2022

Background:
Cardiovascular diseases are now the leading cause of death worldwide, amounting to 17,8% of all deaths recorded. In sub-Saharan Africa, it contributes to about 13% of deaths, whereas 80% were recorded from developing countries. A quarter of all deaths are attributable to behavioural and metabolic risk factors due to patients` lack of self-management strategies, which are practices and activities that the patients can use and manage themselves, effectively preventing the development of CVD.

Objective:
The study aimed to explore patients at risk of CVD’s knowledge of self-management strategies to prevent the development of CVD.

Design:
This was a qualitative exploratory and descriptive study conducted in four primary health care settings in two contexts (i.e a rural and peri-urban setting) in the Capricorn District of Limpopo Province, South Africa. The target population were patients with risk factors and diagnosed with either hypertension or diabetes mellitus. Twenty-five patients (male n=9; female n=16) were purposefully sampled and participated in semi-structured individual interviews with a schedule guide. The data was analysed using thematic Tesch’s open coding qualitative data analysis method.

Results:
Thematically analysed data resulted in three main themes and their related subthemes enumerating patients at risk of CVD’s knowledge regarding disease onset, risk factors, and self-management including daily challenges affecting disease progression. The major themes isolated are, 1) Knowledge related to CVD onset, symptoms, and self-management strategies, 2) Challenges experienced by persons at risk of developing CVD, 3) Suggestions to help improve health and the prevention of the onset of CVD.

Conclusion:
The study concludes by recommending in-depth CVD awareness and education programs for patients at risk. More importantly, the provision of mental health awareness, counselling, and equipping patients with coping skills are recommended.
ANALISIS BIAYA PADA PROYEK URUGAN LIMESTONE RESTORASI DI BIBIR PANTAI NEW GRASS ROOT REFINERY KILANG MINYAK TUBAN
Authors: Sugiyanto  , Joni Setiyono  
Published: November 2022

Dalam penyelenggaraan proyek konstruksi, pengendalian biaya merupakan salah satu sasaran yang sangat penting dalam mencapai status kinerja biaya. Penelitian ini bertujuan menganalisis biaya pada proyek urugan limestone restorasi di bibir pantai new grass root refinery kilang minyak Tuban. Data yang digunakan diperoleh dari PT. Wira Karya Tehnika selaku kontraktor proyek yang memilki anggaran sebesar Rp. 1,596,270,000.00 dengan durasi selama 90 hari dengan jadwal rencana pelaksanaan 19 November 2021 hingga 16 Februari 2022. Metode nilai hasil digunakan dalam analisis dengan meliputi variabel, indikator dan indek nilai hasil. Hasil analisis mendapatkan pola yang terbentuk atas ke-3 variabel nilai hasil pada kurva terpadu dalam durasi proyek minggu ke-1 hingga ke-13 dicapai status kinerja biaya tepat anggaran (on budget). Selanjutnya, hasil analisis sistem pengendalian biaya berdasarkan varian biaya memberikan kepastian yang sangat kuat bahwa kinerja biaya pelaksanaan proyek dapat dikendalikan dengan sangat baik. Akhirnya, hasil analisis sistem pengendalian biaya berdasarkan indek kinerja biaya, merupakan fakta yang tak terbantahkan biaya proyek tersebut dapat dikendalikan dengan sangat baik.
Effect of Hydrothermal Treatment on selected Properties of Cocoyam Corm (colocasia esculenta) Flour
Authors: Asema Kator , Adejumo Bolanle Adenike 
Published: November 2022

The aim of this work is to evaluate the effect of hydrothermal treatment on the physicochemical properties of cocoyam flour. Harvested cocoyam (Colocasia esculenta) was sorted, peeled, washed, sliced, washed, blanched at temperature 60 ̊ C, 80 ̊ C and 100 ̊ C and soaked at different time of 12 hours, 24 hours and 48 hours after then oven dried. The dried samples were milled into flour labelled A, B, and C at three replicates (3×3×3=27) with unblanched and unsoaked sample D as control. The samples were packaged for analysis. Result showed that at temperature 60 ̊ C for soaking time 12 hours, 24 hours and 48 hours, the moisture content are 4.16 %, 3.62 % and 5.01 %, fat 5.22 %, 5.22 % and 4.72 %, crude fibre 0.98 %, 0.99 % and 0.53 %, protein 1.75 %, 1.47 % and 1.61 %. It is concluded that hydrothermal treatment of cocoyam (colocasia esculenta) can modify the physicochemical properties of flour produced. However, the minimum effect occurred at 60 ̊ C compared to 80 ̊ C and 100 ̊ C .thus, the quality of cocoyam flour can be improved using blanching temperature 60 ̊ C and 12 hours soaking time.
Peran Digital Forensik dalam Pembuktian Tempus Delicti Sebagai Upaya Pertanggungjawaban Pidana Pelaku Pembuat Video Pornografi
Authors: Wijanarko Anas Aditya , Ridwan Ridwan , Prakarsa Aliyth 
Published: November 2022

This article aims to discuss the role of digital forensics in proving tempus delicti as an effort to criminal liability for the makers of pornographic video (case study: vina garut video. The role of digital forensics is used in the recent case of pornographic content, namely the Vina Garut video case. This case is a case of immoral videos showing pornographic scenes between several men and a woman, there are at least two videos of Vina Garut that are spread on social media and this makes the Garut Resort Police immediately move to investigate this case. This type of research is empirical juridical. The result of this study lead to the conclusion that based on the results of digital forensic tests, criminal liability should be imposed on the perpetrator of pornographic videos in this Vina Garut video case, namely against female perpetrators in this case with the initials PA can be categorized as victims while against other perpetrators with initials W and D are subject to Article 37 in conjunction with Article 11 of the Pornography Law, this is because the digital forensic results of the PA can still be categorized as victims.

ABSTRAK
Penelitian ini bertujuan untuk untuk membahas tentang peran digital forensik dalam pembuktian tempus delicti sebagai upaya pertanggungjawaban pidana pelaku pembuat video pornografi (studi kasus: video vina garut). Peran digital forensic digunakan dalam kasus konten pornografi yang belum lama ini terjadi yaitu kasus video Vina Garut. Kasus ini merupakan kasus video asusila yang memperlihatkan adegan bermuatan pornografi antara beberapa pria dengan seorang wanita, setidaknya terdapat dua video Vina Garut yang tersebar di media sosial dan hal tersebut membuat Kepolisian Resor Garut langsung bergerak menyelidiki kasus ini. Tipe penelitian ini adalah penelitian yuridis empiris. Hasil Penelitian ini menghasilkan kesimpulan bahwa berdasarkan hasil uji digital forensik maka seharusnya pertanggungjawaban pidana yang dikenakan terhadap para pelaku pembuat video pornografi dalam kasus video Vina Garut ini yaitu terhadap pelaku wanita dalam kasus ini dengan inisial PA dapat dikategorikan sebagai korban sedangkan terhadap para pelaku lain dengan inisial W dan D dikenakan Pasal 37 juncto Pasal 11 Undang-Undang Pornografi hal ini dikarenakan berdasarkan hasil digital forensik PA masih dapat dikategorikan sebagai korban.