bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pencil‐Drawing Graphite Nanosheets: A Simple and Effective Cathode for High‐Capacity Aluminum Batteries
Authors: Yu Jiangkun , Li Xiaojing , Li Na , Wu Tingting , Liu Yanru , Li Caixia , Liu Jie , Wang Lei 
Published: March 2022

AbstractCommercial graphite, as an attractive cathode material, has been extensively applied in rechargeable aluminum batteries. However, low capacity and complex cathode preparation procedures limit its further development. Herein, graphite nanosheets as cathode of aluminum battery have been prepared by a novel pencil‐drawing strategy, which shows superior capacity of 96 mAh g−1 and excellent stability with almost 100% capacity retention after 2000 cycles at a current density of 0.5 A g−1. By increasing charge–discharge current density to 2 A g−1, the battery also exhibits a high capacity of 72 mAh g−1 and retains 90% after 6000 cycles. Furthermore, a stage 3 anion intercalation/deintercalation mechanism has been proposed according to in situ X‐ray diffraction and ex situ characterization techniques. This work provides a controllable method for developing a graphite nanosheets cathode with a simplified process and contributes to the development of other kinds of energy storage devices.
Implementation of the expansion of sensor information storage based on the Internet of Things and cloud computing
Authors: Hu Lei 
Published: March 2022

AbstractIn the era of rapid development of informatization, the Internet of Things (IoT) and cloud computing have also been born and developed, quietly changing our way of life. The application of sensors has also brought great convenience to our lives, but there are still shortcomings that need to be studied in depth. This article aims to study the application and realization of Internet and cloud computing in sensor information storage. Aiming at the problems of sensors with multiple sources of information, large amount of data concurrency and low efficiency, the single‐point data agent is clustered and clustered to achieve high availability of sensor information storage. After a series of experimental results analysis, the information storage system constructed in this article can input 12 700 pieces of information per second and output 134 pieces of information per second. Therefore, sensor information storage based on the IoT and cloud computing has higher work efficiency, safety performance and availability than other sensor information storage. The architecture of information storage based on the IoT and sensors made in this article has far‐reaching significance for the development of smart devices in the future, and has great research value.
Die Netto‐Null als Ziel – erfolgreiche Projektbeispiele für das Bauen nach dem Leitsatz Reduce – Reuse – Recycle
Authors: Stockhusen Knut , Erichsen Jannika 
Published: March 2022

AbstractDie Baubranche steht aktuell vor einer nie dagewesen Herausforderung: Wie können die durch sie verursachten klimaschädlichen Treibhausgase drastisch reduziert und der weltweit steigende Bedarf der gebauten Umwelt gedeckt werden? Gewiss ist: Nachhaltigkeit kann nur durch ganzheitliche architektonische Qualität entstehen. Mindestens genauso wichtig wie die Berücksichtigung der betrieblichen Emissionen sind die Emissionen, die beim Bau selbst entstehen. Denn die Menge dieser von heute bis 2050 entstehenden grauen Emissionen wird für das Erreichen der Klimaziele der Vereinten Nationen entscheidend sein. Die drei R „Reduce – Reuse – Recycle“ sind im Bau unverzichtbar, um diese Ziele erreichen zu können. Im Folgenden werden Projekte präsentiert, die sich an den drei R orientieren und damit erfolgreich demonstrieren, wie innovative Ansätze und Konzepte den Wandel zur Netto‐Null vorantreiben können. Dazu gehören die Überdachung des Olympiastadions in München als Vorbild aller Leichtbauten, das Holz‐Hängedach für das Olympische Wassersportzentrum 2024 in Paris als Beispiel des materialgerechten Entwurfs, die vier Freiform‐Stahl‐Glaskuppeln der Moynihan Train Hall in New York City und das modulare Containerstadion als Beispiele für den Erhalt und die Lebenszyklusverlängerung von Bauwerken oder ganzen Bauteilen, der City of Dream Pavillon „Cast & Place“ aus rezykliertem Aluminium sowie die Jugendreinrichtung Betonoase in Berlin, deren Außenwände und Vordächer aus dem besonders recyclingfreundlichen Infraleichtbeton (ILC) bestehen.
A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2‐positive breast cancer through regulating ferroptosis
Authors: Wang Shengting , Wang Yufang , Li Qian , Li Xiaoming , Feng Xinghua 
Published: March 2022

AbstractHER2‐positive breast cancer is an aggressive subtype of breast cancer, characterized by high malignancy and poor prognosis. Trastuzumab, the first HER2‐targeted monoclonal antibody therapy, has a crucial role in a curative setting in HER2‐positive breast cancer. However, frequent drug resistance inhibits its clinical efficacy. Herein, by performing circular RNA (circRNA) profiling, we identified a novel circRNA, circ‐BGN, as a key contributor in trastuzumab resistance. Circ‐BGN was evidently increased in trastuzumab‐resistant breast cancer cells and tissues, linking to poor overall survival. Knockdown of circ‐BGN inhibited breast cancer cell viability and notably restored its sensitivity to trastuzumab. Further, we found that circ‐BGN could directly bind to OTUB1 and SLC7A11, enhancing OTUB1‐mediated SLC7A11 deubiquitination and thereby inhibiting ferroptosis, a newly recognized form of cell death that is distinct from apoptosis, necrosis, and autophagy. Moreover, erastin, a small‐molecule ferroptosis inducer, could effectively restore the anti‐tumor effect of trastuzumab. Pre‐clinically, the orthotopic tumor model showed that erastin significantly reduced tumor volume generated by trastuzumab‐resistant breast cancer cells, which was more pronounced after combined circ‐BGN knockdown. Collectively, our data reveal a novel circRNA controlling trastuzumab resistance via regulation of ferroptosis, providing a promising therapeutic strategy for trastuzumab‐resistant breast cancer patients.
Using a non‐invasive technique to identify suspected microplastics in grey seals (Halichoerus grypus) living in the western North Sea
Authors: Desclos‐Dukes Lucas , Butterworth Andrew , Cogan Tristan 
Published: March 2022

AbstractBackgroundPlastic pollution is of growing concern in marine ecosystems worldwide. Specifically, microplastics (<5 mm) may interact with a variety of biota with the potential to cause harm to organism health. Studies investigating microplastics are increasing, yet their occurrence within free‐ranging and living marine mammals remains largely unexplored.MethodsBy using a protocol involving enzymatic digestion, filtration and microscopic identification, faecal samples collected from a grey seal (Halichoerus grypus) haul‐out site in the North Sea were investigated for microplastic presence.ResultsAltogether, 71 suspected microplastic particles, consisting of both fibres and fragments in a variety of colours and sizes, were identified across 66 analysed faecal subsamples.ConclusionThe present study indicates that marine mammals are ingesting microplastics and that faecal material can be used to indirectly and non‐invasively record microplastic uptake data in pinnipeds. Since the current paper is the first to document potential microplastic exposure among wild, living and free‐ranging grey seals of the western North Sea, further research is needed to begin to understand the biological significance of these findings.
Managing Forestry in a Sustainable Manner: The Importance of System Analysis
Authors: Stjernquist Ingrid , Schlyter Peter 
Published: March 2022

AbstractThis chapter examines from systems and livelihood perspectives, with Nemoral and Boreal forest zones of the Global North and Sweden as examples, how forestry may meet current and future sustainability challenges both as a traditional resource base and with respect to other ecosystem services. Previous and current forest policy/governance is briefly described against the background that Swedish forestry is based both on huge holdings by few industrial owners as well as on a multitude of small individual, often family owned, forest estates. Successful delivery against environmental objectives will require careful balancing of interests and the active participation of local forest owners. Cumulative effects of old and new societal demands on forestry and their impact on local livelihoods poses in this respect a systemic risk as economic and social sustainability often gets limited consideration. There is a need for a more synoptic and systemic analysis of how forestry is affected by multiple, partly contradictory, demands from an increasing array of stakeholders, in order to enable a move towards a biobased economy. Stakeholder-based group modelling is a potentially powerful analytic and conflict reducing approach that could help improve forestry’s contribution to the acute need to handle the climate change and current sustainability challenges.
Politics, Systems Thinking and Building the Wellbeing Economy: The Example of Wales
Authors: Parker Jenneth 
Published: March 2022

AbstractThis chapter discusses the example of Wales to give insights to how and why a Wellbeing Economy approach has been successfully initiated there, and some idea of its future prospects. The systems aspects of Wellbeing Economy are identified as being inherent in ambitions to develop transitional strategies that can achieve system change through combinations of measures across different aspects of economy, society and ecology. The example of Wales includes the historical, cultural and economic background to help understanding of the bases on which Wellbeing Economy commitments can be supported in a population. The chapter concludes with some general points about the value of systems tools and approaches in helping to really bring Wellbeing Economy topics off the page and into reality. In particular, the complexity of the task of Wellbeing Economy is suited to systems approaches that can help to map coherent relationships between different areas and also aid in moving from loose alliances to more synergies. These tools and approaches can be powerful when combined with the extensive local knowledge and motivation that exists wherever we find communities and individuals working for a better future.
Models of Change: Strategies to Make the Socio-ecological Transformation a Success
Authors: Kristof Kora 
Published: March 2022

AbstractClimate change and many other problems show us more and more clearly that fundamental change is necessary. However, many good ideas get stuck in implementation. Therefore, the question is how we can change more successfully. We take sports courses or go to music lessons to learn, to get better quickly or to avoid hurting ourselves. Professionals in sport, art and other fields also receive intensive coaching from experts. However, when it comes to making successful progress towards sustainability, people often rely on ‘home recipes’. It is time to become more professional in this area as well. To achieve this, it is important to make targeted use of the findings of transformation research and key success factors as well as to develop transformation literacy. In this chapter, the models of change approach is presented, which focuses on central success factors for social change and shows ways to successful change.
Small Scale, Large Scale—Why Networks are the Cornerstone of Transformations
Authors: Kühn Elisabeth 
Published: March 2022

AbstractThis chapter takes a deep dive into the practice of transformative change. It suggests that transformation literacy needs to incorporate the understanding that achieving the vision of vital and regenerative systems requires actors to drive change that models the future systems aliveness. Only then can they become successful transformation systems. Practical experience gives evidence that the shift to transformative impact happens best in enlivening networks across systems, in what is calledtransformation networks. This chapter shows that a necessary systemic perspective on transformation network means they can and need to be strategically built. It introduces sixtransformation networkenablersthat support such strategic guidance in building networks, that were used in two practical examples of setting up transformation networks. The first example is on the local level and looks at a network of youth civil society for good governance in central Tunisia. The second example is on the other end of the spectrum: it examines a global network of professionals towards a new economic future.
Collective Stewardship Towards Life Economies
Authors: Kuenkel Petra 
Published: March 2022

AbstractThis chapter explores how different actors, who drive an urgently needed economic systems change, can become part of a more coherent transformation system by focusing on a unifying future narrative: creating economiesin service to life. The understanding of what gives life to systems is an overarching guiding force of the manifold transformative efforts that already exist. Based on an extensive literature review of new economic approaches, the chapter introduces a combination of guiding principles for new economies that would safeguard planetary and human integrity, while allowing for different interpretations and manifestations. It shows that for most principles, implementation strategies already exist. However, the so urgent systems transformations require combined efforts and an approach of collective stewardship by multiple actors, across societal sectors, cultures and institutions. The chapter elaborates how the adoption of a systems aliveness approach informs collective stewardship. The conscious choice of a constellation of strategic drivers, if applied together, increases the leverage of transformative efforts. The chapter concludes with deliberations on how to use the guiding principles and strategic drivers as an entry point for creating pathways towards regenerative civilizations, in which planetary life-support systems are as much valued as the dignity of people.
Global existence in reaction–diffusion systems with mass control under relaxed assumptions merely referring to cross-absorptive effects
Authors: Lankeit Johannes , Winkler Michael 
Published: March 2022

AbstractWe introduce a generalized concept of solutions for reaction–diffusion systems and prove their global existence. The only restriction on the reaction function beyond regularity, quasipositivity and mass control is special in that it merely controls the growth of cross-absorptive terms. The result covers nonlinear diffusion and does not rely on an entropy estimate.
The effect of migration on unionization in Austria
Authors: Antón José-Ignacio , Böheim René , Winter-Ebmer Rudolf 
Published: March 2022

AbstractWe analyze how native employees’ union membership rates change in response to foreign employees using Austrian administrative data for the period 2002 to 2012. Using an instrumental variables approach, our results indicate a negative effect of immigrant employees on native employees’ unionization rates at the firm level. The negative effect is the result of a greater—mostly voluntary—turnover of unionized native employees in firms with a larger share of migrants, but it is not caused by native employees leaving unions or firms’ reduced hiring of native union members.
Wheat amylase/trypsin inhibitors (ATIs): occurrence, function and health aspects
Authors: Geisslitz Sabrina , Weegels Peter , Shewry Peter , Zevallos Victor , Masci Stefania , Sorrells Mark , Gregorini Armando , Colomba Mariastella , Jonkers Daisy , Huang Xin , De Giorgio Roberto , Caio Giacomo P. , D’Amico Stefano , Larré Colette , Brouns Fred 
Published: March 2022

AbstractAmylase/trypsin inhibitors (ATIs) are widely consumed in cereal-based foods and have been implicated in adverse reactions to wheat exposure, such as respiratory and food allergy, and intestinal responses associated with coeliac disease and non-coeliac wheat sensitivity. ATIs occur in multiple isoforms which differ in the amounts present in different types of wheat (including ancient and modern ones). Measuring ATIs and their isoforms is an analytical challenge as is their isolation for use in studies addressing their potential effects on the human body. ATI isoforms differ in their spectrum of bioactive effects in the human gastrointestinal (GI), which may include enzyme inhibition, inflammation and immune responses and of which much is not known. Similarly, although modifications during food processing (exposure to heat, moisture, salt, acid, fermentation) may affect their structure and activity as shown in vitro, it is important to relate these changes to effects that may present in the GI tract. Finally, much of our knowledge of their potential biological effects is based on studies in vitro and in animal models. Validation by human studies using processed foods as commonly consumed is warranted. We conclude that more detailed understanding of these factors may allow the effects of ATIs on human health to be better understood and when possible, to be ameliorated, for example by innovative food processing. We therefore review in short our current knowledge of these proteins, focusing on features which relate to their biological activity and identifying gaps in our knowledge and research priorities.
Development and characterization of anti-fibrotic natural compound similars with improved effectivity
Authors: Kreutzer Fabian Philipp , Meinecke Anna , Mitzka Saskia , Hunkler Hannah Jill , Hobuß Lisa , Abbas Naisam , Geffers Robert , Weusthoff Jan , Xiao Ke , Jonigk Danny David , Fiedler Jan , Thum Thomas 
Published: March 2022

AbstractCardiac fibroblasts constitute the major cell type of the murine and human heart. Once activated, they contribute to an excessive deposition of extracellular matrix (ECM) leading to cardiac fibrosis and subsequently organ dysfunction. With the exception of the pulmonary drugs, nintedanib and pirfenidone, drugs specifically targeting anti-fibrotic pathways are scarce. We recently performed large library screenings of natural occurring compounds and identified first lead structures with anti-fibrotic properties in vitro and in vivo. In line, we now aimed to improve efficacy of these anti-fibrotic lead structures by combining in vitro validation studies and in silico prediction. Next to this combined approach, we performed large OMICs-multi-panel-based mechanistic studies. Applying human cardiac fibroblasts (HCF), we analysed 26 similars of the initially identified anti-fibrotic lead molecules bufalin and lycorine and determined anti-proliferative activity and potential toxicity in an array of in vitro and ex vivo studies. Of note, even at lower concentrations, certain similars were more effective at inhibiting HCF proliferation than nintedanib and pirfenidone. Additionally, selected similars showed low cytotoxicity on human iPS-derived cardiomyocytes and anti-fibrotic gene regulation in human ex vivo living myocardial slices. Further, array and RNA sequencing studies of coding and non-coding RNAs in treated HCFs revealed strong anti-fibrotic properties, especially with the lycorine similar lyco-s (also known as homoharringtonine), that led to a nearly complete shutdown of ECM production at concentrations 100-fold lower than the previously identified anti-fibrotic compound lycorine without inducing cellular toxicity. We thus identified a new natural compound similar with strong anti-fibrotic properties in human cardiac fibroblasts and human living heart tissue potentially opening new anti-fibrotic treatment strategies.
Seizures and risks for recurrence in critically ill patients: an observational cohort study
Authors: Wagner Anna S. , Semmlack Saskia , Frei Anja , Rüegg Stephan , Marsch Stephan , Sutter Raoul 
Published: March 2022

Abstract
Background
To assess the frequency and clinical characteristics of seizures in adult critically ill patients, to identify predictors of recurrent seizures not transforming into status epilepticus and to characterize their effects on course and outcome.

Methods
ICU patients at a Swiss academic medical center with seizures not transforming into status epilepticus from 2015 to 2020 were included. Recurrent seizures and associated clinical characteristics were primary, death, and return to premorbid neurologic function were secondary outcomes.

Results
Two hundred of 26,370 patients (0.8%) with a median age of 65 years had seizures during ICU stay. Seizure semiology was described in 82% (49% generalized; 33% focal) with impaired consciousness during seizures in 80% and motor symptoms in 62%. Recurrent seizures were reported in 71% (36% on EEG) and associated with longer mechanical ventilation (p = 0.031), higher consultation rate by neurologists (p < 0.001), and increased use of EEG (p < 0.001) when compared to single seizures. The use of EEG was not associated with secondary outcomes. Acidosis at seizure onset and prior emergency operations were associated with decreased odds for seizure recurrence (OR 0.43; 95% CI 0.20–0.94 and OR 0.48; 95% CI 0.24–0.97). Epilepsy had increased odds for seizure recurrence (OR 3.56; 95% CI 1.14–11.16).

Conclusions
Seizures in ICU patients are infrequent, but mostly recurrent, and associated with higher resource utilization. Whenever seizures are observed, clinicians should be vigilant about the increased risk of seizures recurrence and the need for antiseizure treatment must be carefully discussed. While known epilepsy seems to promote recurrent seizures, our results suggest that both acidosis and previous emergency surgery seem to have protective/antiseizure effects.

Trial registration
Clinicaltrials.gov (No. NCT03860467).