bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel mortality risk score for emphysematous pyelonephritis: A multicenter study of the Global Research in the Emphysematous Pyelonephritis group
Authors: Trujillo-Santamaría Hegel , Robles-Torres José Iván , Teoh Jeremy Yuen-Chun , Tanidir Yiloren , Campos-Salcedo José Gadú , Bravo-Castro Edgar Iván , Wroclawski Marcelo Langer , Yeoh W. S. , Kumar Santosh , Sanchez-Nuñez Juan Eduardo , Espinoza-Aznar José Enrique , Ragoori Deepak , Hamri Saeed Bin , Aik Ong Teng , Tarot-Chocooj Cecil Paul , Shrestha Anil , Lakmichi Mohamed Amine , Cosentino-Bellote Mateus , Vázquez-Lavista Luis Gabriel , Kabre Boukary , Tiong Ho Yee , Arrambide-Herrera José Gustavo , Gómez-Guerra Lauro Salvador , Kutukoglu Umut , Alves-Barbosa Joao Arthur Brunhara , Jaspersen Jorge , Acevedo Christian , Virgen-Gutiérrez Francisco , Agrawal Sumit , Duarte-Santos Hugo Octaviano , Ann Chai Chu , Castellani Daniele , Gahuar Vineet 
Published: November 2022

Abstract

Background
Emphysematous pyelonephritis (EPN) is a necrotizing infection of the kidney and the surrounding tissues associated with considerable mortality. We aimed to formulate a score that classifies the risk of mortality in patients with EPN at hospital admission.

Materials and methods
Patients diagnosed with EPN between 2013 and 2020 were retrospectively included. Data from 15 centers (70%) were used to develop the scoring system, and data from 7 centers (30%) were used to validate it. Univariable and multivariable logistic regression analyses were performed to identify independent factors related to mortality. Receiver operating characteristic curve analysis was performed to construct the scoring system and calculate the risk of mortality. A standardized regression coefficient was used to quantify the discriminating power of each factor to convert the individual coefficients into points. The area under the curve was used to quantify the scoring system performance. An 8-point scoring system for the mortality risk was created (range, 0–7).

Results
In total, 570 patients were included (400 in the test group and 170 in the validation group). Independent predictors of mortality in the multivariable logistic regression were included in the scoring system: quick Sepsis-related Organ Failure Assessment score ≥2 (2 points), anemia, paranephric gas extension, leukocyte count >22,000/μL, thrombocytopenia, and hyperglycemia (1 point each). The mortality rate was <5% for scores ≤3, 83.3% for scores 6, and 100% for scores 7. The area under the curve was 0.90 (95% confidence interval, 0.84–0.95) for test and 0.91 (95% confidence interval, 0.84–0.97) for the validation group.

Conclusions
Our score predicts the risk of mortality in patients with EPN at presentation and may help clinicians identify patients at a higher risk of death.
Impact of surgical management of upper tract urothelial cancer in octogenarians: A population-based study
Authors: Wang Shu , Phelan Michael , Siddiqui Mohummad Minhaj 
Published: November 2022

Abstract

Background
Upper tract urothelial carcinoma (UTUC) is an aggressive disease with a high progression rate. The standardmanagement for this disease is nephroureterectomy. Nephron sparing nonradical surgery is an alternative therapeutic approach. In men with limited life expectancy, the potential harm of UTUC progression must be weighed against surgical morbidity and mortality, and thus, more conservative approaches may be selected. This study aims to investigate the comparative benefits of radical and conservative surgical management in patients older than 80 years with localized UTUC.

Materials and methods
A search was conducted in the Surveillance, Epidemiology, and End Results database for patients older than 80 years who were diagnosed with localized (T1–2N0M0) cancer in the renal pelvis or ureter as the only malignancy from 2004 to 2015. Patients were divided into 3 therapeutic groups: no surgery, local intervention (ie, local tumor excision or segmented ureterectomy), and radical surgery (nephroureterectomy). Demographic and cancer-related parameter data were collected. Logistic regression analysis was conducted to investigate predictors for surgical treatment. Kaplan-Meier curves and Cox regression were used to analyze survival outcomes.

Results
Data from 774 patients were analyzed, including 205 in the no-surgery group, 181 in the local intervention group, and 388 in the radical surgery group. Older, African American patients with T1 stage disease were less likely to receive surgical treatment. Among surgically treated patients, renal pelvic tumors, and high-grade and T2 stage disease were associated with radical resection. Surgically treated patients had a longer median overall survival (OS) than in those treated nonsurgically (13, 35, and 47 months in no-surgery, local intervention, and radical surgery groups, respectively; p < 0.001). Although surgically treated patients demonstrated higher 5-year OS (8.8% [no surgery], 23.2% [local intervention], and 23.5% [radical surgery], p < 0.001) and 5-year disease-specific survival (DSS) (41.0%[no surgery], 69.1%[local intervention], and 72.9%[radical surgery]; p < 0.001) than in those treated nonsurgically, no significant differences were found between the local intervention and radical surgery groups (p > 0.05). Based on multivariate Cox regression analysis, surgical treatments, including both nonradical and radical resection, were independently associated with improved OS and DSS after controlling for age, marital status, tumor grade, and radiation status.

Conclusions
Patients older than 80 years with localized UTUC who undergo surgery demonstrate longer survival. Radical and nonradical resections seemto have similar OS and DSS outcomes. Thus, when clinically indicated in this population, a more conservative surgical approach may be reasonable.
Argument for Prompt Corneal Cross-Linking on Diagnosis of Keratoconus in a Pediatric Patient
Authors: Henriquez Maria A. 
Published: November 2022

Abstract:
Strong evidence suggests that corneal crosslinking is a safe procedure capable of stopping or slowing down the progression of keratoconus, avoiding visual loss associated with progression, and delaying or preventing the need for corneal transplantation. The progressive and chronic nature of the disease makes the option for prompt crosslinking upon keratoconus diagnosis in a pediatric patient valid.
A comparison of 3 productive authors’ research domains based on sources from articles, cited references and citing articles using social network analysis
Authors: Ho Sam Yu-Chieh , Chien Tsair-Wei , Huang Chien-Cheng , Tsai Kang-Ting 
Published: November 2022

Background:
An individual’s research domain (RD) can be determined from objective publication data (e.g., medical subject headings and Medical Subject Headings (MeSH) terms) by performing social network analysis. Bibliographic coupling (such as cocitation) is a similarity metric that relies on citation analysis to determine the similarity in RD between 2 articles. This study compared RD consistency between articles as well as their cited references and citing articles (ARCs).

Methods:
A total of 1388 abstracts were downloaded from PubMed and authored by 3 productive authors. Based on the top 3 clusters in social network analysis, similarity in RD was observed by comparing their consistency using the major MeSH terms in author articles, cited references and citing articles (ARC). Impact beam plots with La indices were drawn and compared for each of the 3 authors.

Results:
Sung-Ho Jang (South Korea), Chia-Hung Kao (Taiwan), and Chin-Hsiao Tseng (Taiwan) published 445, 780, and 163 articles, respectively. Dr Jang’s RD is physiology, and Dr Kao and Dr Tseng’s RDs are epidemiology. We confirmed the consistency of the RD terms by comparing the major MeSH terms in the ARC. Their La indexes were 5, 5, and 6, where a higher value indicates more extraordinary research achievement.

Conclusion:
RD consistency was confirmed by comparing the main MeSH terms in ARC. The 3 approaches of RD determination (based on author articles, the La index, and the impact beam plots) were recommended for bibliographical studies in the future.
Enhancement of fluoride release in glass ionomer cements modified with titanium dioxide nanoparticles
Authors: Morales-Valenzuela Adriana Alejandra , Scougall-Vilchis Rogelio José , Lara-Carrillo Edith , Garcia-Contreras Rene , Hegazy-Hassan Wael , Toral-Rizo Víctor Hugo , Salmerón-Valdés Elias Nahum 
Published: November 2022

Background:
Several efforts have been made to improve the glass ionomer cements (GICs) properties with nanotechnology. Fluoride release in once of most beneficial properties of GICs. The purpose of this study was to evaluate the fluoride release, recharge, and cytotoxicity in GICs reinforced with titanium dioxide nanoparticles (TiO2N).

Objective:
Evaluate the fluoride release, recharge, and cytotoxicity in GICs reinforced with TiO2N.

Methods:
Four GICs, FUJI IX EXTRA (G1c), KETAC MOLAR (G2c), IONOFILL MOLAR (G3c), and FUJI IX (G4c) were combined with TiO2N (G1e, G2e, G3e, and G4e) and divided into blocks of 5-mm width and 1-mm thickness 10 each. A total of 80 samples were arranged as follows: GICs alone as negative control (n = 40) and GICs + TiO2N as experimental groups (n = 40). The fluoride release was determined for periods of 1, 2, 6, 10, 31, 90, 180, 240, and 300 days. On days 30 and 179, samples were recharged by submerging in 1 mL of 20,000 ppm sodium fluoride gel. Cytotoxic activity was carried out with gingival fibroblasts, using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide cell viability assay.

Results:
The experimental groups obtained the highest and more constant fluoride released when compared to control groups. After the first recharge, experimental groups (G1e, G3e, and G4e) showed statistically significant results (P = .001, 0.010, and 0.001 respectively) enhancing their recharge ability regarding control groups. The second recharge showed better results in G1e concerning the rest of the groups. No cytotoxic activity was observed in all experimental groups, although significant differences were observed in G3e and G4e regarding control group.

Conclusion:
The incorporation of TiO2N enhance the fluoride release in glass ionomers with a noncytotoxic effect on human gingival fibroblasts.
Wound exudate reduction from retroperitoneum with facilitation of healing by triamcinolone injection: A case report
Authors: Tsunekawa Kazuhiro , Yuzuriha Shunsuke 
Published: November 2022

Rationale:
Maintaining a moderately moist environment is important in the treatment of chronic skin ulcers. Excessive exudate inhibits wound healing, although it may be difficult to control. We report a case of successful treatment with triamcinolone to suppress retroperitoneal exudates and facilitate wound healing.

Patient concerns:
A 78-year-old man presented to our department with excessive exudative oozing from a chronic ulcer in the gluteal region. The retroperitoneum was exposed for a prolonged period after colon cancer surgery and developed chronic granulation.

Diagnoses:
The exposed retroperitoneum was covered using an island flap, with the left superior gluteal artery perforator providing the feeding vessels and skin graft, which covered part of the flap harvesting area. The flap and lower bed did not adhere because of the presence of an excessive retroperitoneal exudate. Skin grafts to the flap harvesting area were not accepted, and secondary healing did not proceed because of exudate leakage.

Intervention:
A single dose of 2.5-mg triamcinolone was injected inferiorly to the flap.

Outcomes:
After injection of triamcinolone, the exudate decreased, and secondary healing in the residual ulcer progressed satisfactorily.

Conclusion:
Injection of triamcinolone might be an option for controlling exudates to heal skin ulcers.
Comparing the accuracy of shear wave elastography and strain elastography in the diagnosis of breast tumors: A systematic review and meta-analysis
Authors: Wu Huayu , Wang Cong , An Qi , Qu Xiaomeng , Wu Xiaohang , Yan Yumei 
Published: November 2022

Background:
Shear wave elastography (SWE) and strain elastography (SE) are 2 new ultrasonic technologies which have developed rapidly in recent years. Elastography transforms the elastic information of tissue into optical information for display, thus more intuitive display of tissue elasticity. Conflicting results have been obtained in different scholars’ studies on the accuracy comparison of the 2 elastography technologies in the diagnosis of breast tumors. This meta-analysis aims to compare the accuracy of the 2 elastography technologies in the diagnosis of breast tumors, and provide a reference for clinical decision making.

Methods:
We have searched Chinese and English literatures on the accuracy of SWE and SE in the diagnosis of breast tumors from PubMed, Web of Science, China national knowledge infrastructure and Wanfang databases, and the time was up to December30, 2020. Two literature reviewers screened the literatures according to the screening criteria, and Quality Assessment of Diagnostic Accuracy Study tool was used to evaluate the quality of included literatures. Meta Disc1.4 and Stata14.0 softwares were used to perform heterogeneity test, sensitivity analysis and publication bias test.

Results:
Ten literatures included 1599 patients and 1709 breast lesions. The final results in the SWE as follow: The pooled sensitivity was 0.852 (95% confidence interval [CI] [0.826–0.874]), the pooled specificity (Spe) was 0.799 (95% CI [0.776–0.820]), the pooled positive likelihood ratio was 4.758 (95% CI [3.443–6.576]), the pooled negative likelihood ratio was 0.192 (95% CI [0.147–0.250]), the pooled diagnostic odds ratio was 29.071 (95% CI [16.967–49.811]), and the area under the summary receiver operating characteristic curve was 0.9159. The final results in the SE as follow: The pooled sensitivity was 0.843 (95% CI [0.817–0.866]), the pooled Spe was 0.766 (95% CI [0.743–0.789]), the pooled positive likelihood ratio was 4.387 (95% CI [3.088–6.233]), the pooled negative likelihood ratio was 0.216 (95% CI [0.179–0.261]), the pooled diagnostic odds ratio was 22.610 (95% CI [15.622–32.724]), and the area under the summary receiver operating characteristic curve was 0.8987.

Conclusion:
The sensitivity and Spe of SWE were higher than those of SE, suggesting that SWE may have a higher accuracy in the diagnosis of breast tumors.

Register name:
PROSPERO. Registration number: CRD42021251110.
Diagnostic performance of mono-exponential DWI versus diffusion kurtosis imaging in breast lesions: A meta-analysis
Authors: Wang Yewu , Jin Yumei , Li Mou , Zhang Jun , Wang Shaoyu , Zhang Huapeng , Song Bin 
Published: November 2022

Background:
This meta-analysis aimed to explore the diagnostic value of diffusion kurtosis imaging (DKI) compared to mono-exponential diffusion weighted imaging (DWI) in the diagnosis of breast cancer.

Methods:
A systematic electronic literature search (up to September 2020) was conducted for published English-language studies comparing the diagnostic values of DKI and DWI for the detection of breast cancer. The data of mean kurtosis (MK), mean diffusivity (MD), and apparent diffusion coefficient (ADC) were extracted to construct 2 × 2 contingency tables. The pooled sensitivities, specificities, and areas under the receiver operating characteristic curve (AUCs) were compared between DKI and DWI in the diagnosis of breast cancer.

Results:
Eight studies were finally included, with a total of 771 patients in the same population. Pooled sensitivities were 82.0% [95% confidence interval (95% CI), 78.2‐85.3%] for ADC, 87.3% (95% CI, 83.9‐90.1%) for MK, and 83.9% (95% CI, 80.2‐87.1%) for MD. Pooled specificities were 81.1% (95% CI, 76.7‐84.9%) for ADC, 85.1% (95% CI, 81.1‐88.5%) for MK, and 83.2% (95% CI, 79.0‐86.8%) for MD. According to the summary receiver operator characteristic curve analyses, the AUCwas 0.901 for ADC, 0.930 for MK, and 0.918 for MD (ADC vs MK, P = .353; ADC vs MD, P = .611). No notable publication bias was found, while significant heterogeneity was observed.

Conclusions:
Although DKI is feasible for identifying breast cancer, MD and MK offer similar diagnostic performance to ADC values. Thus, we recommend that DKI should not be included in the routine evaluation of breast lesions now.
Transient asystole during balloon dilation of the Eustachian tube: A case report
Authors: Chung Mee Young , Shin Min Jung , Cha Seung Hee , Lee Ji Yung 
Published: November 2022

Rationale:
Neurally mediated reflexes can induce cardiac arrest during head and neck surgery through mechanisms including direct vagal stimulation, trigeminocardiac reflex, and baroreceptor reflex. Balloon dilation of the Eustachian tube (BDET) is a safe procedure without serious complications, including cardiac arrest.

Patient concerns:
Transient asystole developed during BDET under general anesthesia in a 33-year-old woman as soon as the balloon in the Eustachian tube (ET) was inflated.

Diagnoses:
Monitoring records were reviewed. The asystolic period was recorded on the patient monitor as an event, which we recalled and printed. The asystole lasted for 13 seconds.

Interventions:
The patient recovered sinus rhythm spontaneously after the balloon was deflated before resuscitation. The BDET was successfully performed after prophylaxis with vagolytic drugs.

Outcomes:
The patient recovered uneventfully after anesthesia.

Lessons:
BDET, previously known to be a relatively safe procedure, induces asystole via balloon dilation. It is thought to be a neurally mediated vagal reflex, and both anesthesiologists and otologic physicians should pay proper attention to monitoring during the procedure.
Secondary oxalate nephropathy and kidney transplantation
Authors: Aziz Fahad , Jorgenson Margaret , Garg Neetika 
Published: November 2022

Purpose of review
Secondary hyperoxaluria is associated with poor kidney allograft outcomes after the kidney transplant. Calcium oxalate (CaOx) deposition is common in early allograft biopsies leading to acute tubular necrosis and poor kidney allograft function. Though treatment options for secondary hyperoxaluria are limited, it is crucial to identify patients at increased risk of oxalate nephropathy after the transplant.

Recent findings
Recent data suggest that significant changes in renal replacement therapies and dietary modifications in high-risk patients can prevent kidney allograft damage from the calcium oxalate deposition leading to improve allograft outcomes.

Summary
The accurate and timely diagnosis of secondary oxalate nephropathy in kidney transplant recipients is paramount to preserving graft function in the long-term. This review will discuss the incidence, risk factors, prevention, and management of oxalate nephropathy in the kidney allograft.
18F-FDG PET/CT of Primary Extraskeletal Ewing Sarcoma of the Prostate
Authors: Guo Yue-Hong , Yang Min-Fu 
Published: November 2022

Abstract
Prostate Ewing sarcoma is rare. We report the 18F-FDG PET/CT finding of a 16-year-old adolescent boy who presented with dysuria and was confirmed to be extraskeletal Ewing sarcoma of the prostate by histopathologic findings.
Primary Aortic Epithelioid Angiosarcomas With Metastatic Disease Detected by 18F-FDG PET/CT
Authors: Guan Meichao , Liu Wei , Huang Jianmin , Wei Lingge , Xie Peng 
Published: November 2022

Abstract
Epithelioid angiosarcoma in the aortic arch with metastatic disease is extremely rare. We report a case of 63-year-old man with suspected bone metastases who underwent 18F-FDG PET/CT for seeking the potential primary tumor. PET/CT demonstrated intense FDG uptake in the aortic arch with multiple FDG-avid lesions involving the lung, lymph nodes, and bones. Finally, the diagnosis of primary aortic epithelioid angiosarcomas with metastatic disease was confirmed.
68Ga-DOTA-FAPI-04 PET/CT Imaging in a Case of Radioactive Iodine–Induced Chronic Parotitis
Authors: Xu Tingting , Zhang Yan , Wu Ruilin , Ding Haoyuan , Chen Yue 
Published: November 2022

Abstract

68Ga-DOTA-FAPI-04 is a promising PET agent for tumor imaging. However, inflammatory lesions can also show increased FAPI uptake. Herein, we reported a 52-year-old woman who underwent total thyroidectomy for thyroid papillary carcinoma 1 year ago and underwent adjuvant radioiodine therapy 1 month later. After 131I therapy, she began to develop pain and swelling in bilateral cheeks, which developed into oral dryness. The patient was diagnosed with radioactive iodine–induced parotitis. 68Ga-DOTA-FAPI-04 PET/CT showed the density of bilateral parotid glands increased, and the volume decreased with intense tracer uptake. 99mTcO4
− salivary gland scintigraphy showed decreased tracer uptake in the bilateral parotid glands.
Robotic Approach for Lymphadenectomy in Biliary Tumors
Authors: Ratti Francesca , Cipriani Federica , Ingallinella Sara , Tudisco Antonella , Catena Marco , Aldrighetti Luca 
Published: November 2022

Objective:
This study aimed to evaluate the oncological adequacy of lymphadenectomy (LND) for biliary tumors and surgical outcomes of resections performed using robotic, laparoscopic, and open approaches and to compare the techniques within a weighted propensity score analysis.

Background:
The need to perform formal LND is considered a limit for the applicability of minimally invasive liver surgery.

Methods:
Overall, 25 robotic resections with LND (2021-2022) from a single-center constituted the study group (Rob group), matched by inverse probability treatment weighting with 97 laparoscopic (Lap group) and 113 open (Open group) procedures to address the primary endpoint. A “per-period” analysis was performed comparing the characteristics and outcomes of the Rob group with the first 25 consecutive laparoscopic liver resections with associated LND (LapInit group).

Results:
Minimally invasive techniques performed equally well regarding the number of harvested nodes, blood transfusions, functional recovery, length of stay, and major morbidity and provided a short-term benefit to patients when compared with the open technique. A better performance of the robotic approach over laparoscopic approach (and both approaches over the open technique) was recorded for patients achieving LND with retrieval of >6 nodes. The open approach reduced both the operative time and time for LND, and robotic surgery performed better than laparoscopic surgery.

Conclusions:
Minimally invasive techniques are excellent tools for the management of LND in patients with biliary tumors, showing feasibility, and oncological adequacy. Robotics could contribute to the large-scale diffusion of these procedures with a high profile of complexity.