bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacto do consumo de ultraprocessados à saúde infantil em tempos de COVID-19: Uma revisão
Authors: Barros Loren Carine Alves , Landim Liejy Agnes dos Santos Raposo 
Published: November 2022

Objetivo: Discutir sobre o impacto do consumo de alimentos ultraprocessados à saúde infantil em tempos de pandemia da COVID-19. Metodologia: Revisão narrativa da literatura realizada por meio de busca bibliográfica de artigos em inglês e português, disponíveis nas bases de dados: Scielo, Biblioteca Virtual de Saúde (BVS), Google acadêmico e PubMed. Foram incluídos artigos com datas de publicação dos últimos cinco anos. Os descritores utilizados foram: “COVID-19”, “Nutrição infantil”, “Infant nutrition”, “Eating habits” e “Hábitos alimentares”. Resultados: As estratégias utilizadas para limitar a disseminação da COVID-19, como o distanciamento social e suspensão das aulas, causam impacto direto na alimentação, com isso, há um maior consumo de ultraprocessados e enlatados, por serem produtos mais fáceis de adquirir, armazenar e apresentarem maior prazo de validade. Esse tipo de alimento possui baixo valor nutricional e valor calórico elevado, são ricos em gorduras saturada e trans, carboidratos refinados e baixos níveis de fibra, gordura insaturada, micronutrientes e antioxidantes. Atuam negativamente na imunidade, causando inflamação crônica, manifestação ou agravamento de sobrepeso e obesidade, prejudicando a defesa do organismo contra patógenos virais, representando um alto risco para a patologia grave da COVID-19. Considerações finais: As mudanças relacionadas as restrições causadas pela pandemia refletiram nos maus hábitos alimentares e, consequentemente, o agravamento de doenças crônicas não transmissíveis. Manter uma alimentação saudável e equilibrada é essencial, pois reduz os impactos negativos promovidos pelo SARS-Cov2, visto que alimentos in natura influenciam direta e positivamente o sistema imunológico, fortalecendo-o de possíveis problemas futuros e prevenindo também a obesidade infantil.
Programa Saúde na Escola: Uma análise comparativa
Authors: Rocha Bárbara Decarli , Almeida Bruna Sousa de , Nunes Caroline Jonas Ricomini Regazhi 
Published: November 2022

O Programa Saúde na Escola, instituído em 2007, caracteriza-se por ações intersetoriais entre saúde e educação que visam promover saúde, prevenir agravos e prestar atendimento integral aos estudantes. As ações a serem desenvolvidas são pactuadas a cada 2 anos. Sendo assim, este trabalho tem como objetivo realizar uma análise comparativa dos primeiros anos dos biênios 2019/2020 e 2021/2022 do Programa Saúde na Escola no Distrito Federal e compreender as particularidades, tais como percentual de cobertura, adesão, monitoramento e avaliação. Além disso, identificar o território das escolas em que as ações ocorreram. Metodologia: Pesquisa qualitativa comparativa de abordagem mista, utilizando fonte de dados públicos do Sistema de Informação da Atenção Básica. Resultados e Discussão: foram obtidos dados referente aos anos de 2019 e 2021, sendo eles a quantidade de atividades coletivas, o turno em que ocorreram, o tema de saúde abordado, a prática de saúde realizada, o público alvo participante e o INEP da escola em que a ação ocorreu. Foram considerados apenas o primeiro ano de cada ciclo, pois ambos já estavam encerrados, esse fato viabilizou a realização da discussão comparativa. Conclusão: O Programa Saúde na Escola é uma ferramenta potente na promoção de saúde, e deve ser alvo de incentivo de pesquisa na saúde pública.
Análise de Sepse Neonatal no Hospital Santa Isabel de Sergipe
Authors: Cerqueira Daniel Barbosa , Silva Décio Fragata da , Lima Sônia Oliveira 
Published: November 2022

Introdução. A sepse neonatal é uma patologia infecciosa de alto índice de morbidade e mortalidade, que ocorre até 28º dia de vida e pode caracterizada como precoce quando ocorre até as primeiras 72 horas de vida e tardia quando ocorrer depois desse tempo e tem geralmente sintomas clínicas associados a desordens sistêmicas, tendo as culturas de micro organismo como grande auxílio no diagnóstico e o tratamento é realizado em ambiente hospitalar. Método. Foi aplicado um formulário de 55 itens analisando um total de 273 pacientes com diagnóstico de sepse neonatal, sendo utilizado para análise dos dados Statistical Package for the Social Sciences. Objetivo. Apresentar os dados de padrão significativos de epidemiologia no Hospital Santa Isabel, tendo comparativo com a literatura atual. Resultados. Foi encontrada significância e concordância na literatura com os dados analisados sobre características do nascimento (peso ao nascer e prematuridade), relação direta também ao tipo de sepse e suas caraterísticas, como também avaliação da vitalidade no nascimento e os procedimentos invasivos realizados e sua associação com o desfecho do paciente. Conclusão. O baixo peso, prematuridade, apagar abaixo de 7 e procedimentos invasivos são os maiores preditores negativos para sobrevida dos recém-nascidos.
SYNTHESIS OF SALTS OF N-ALLYLTRICHLOROACETAMIDINIUM HEXAHALOGENOTELLURATE
Authors: Povidaichik Mariana , Shalimov Oleksandr , Onysko Mykhailo , Onysko Petro 
Published: November 2022

Amidines with a trichloromethyl group exhibit the properties of inotropic agents, which are used as scaffolds in synthesizing aza-hete­rocycles and ligands for complex formation. Functionalized amidines show anticancer, and antidiabetic activity, and are antihypertensive and antiparasitic agents. The synthesis of new functional derivatives of such amidines is definitely an urgent task. The introduction of an alkenyl substituent and several nucleophilic centers in the amidine creates prerequisites for electrophilic cyclization. This work aims to study the reactions of N-allyl-N-methyl-N'-(trimethylsilyl)-2,2,2-trichloroethanimidamide with tellurium halides.
The starting N-allyl-N-methyl-N'-(trimethylsilyl)-2,2,2-trichloroethanimidamide was synthesized from N-allyl-N-methyl-­2,2,2-­trichloroethanimidamide by the action of trimethylsilyl chloride in the presence of triethylamine base. The reaction of N-­allyl-­N-methyl-N'-(trimethylsilyl)-2,2,2-trichloroethanimidamide with tellurium dioxide in hydrohalic acid was carried out while cooling to 0°C. Elemental analysis confirms that the electrophilic reagent is in its acidic form in the complex. The 1H NMR spectra of the obtained complexes indicate the absence of EVC - the spin pattern of the proton signals of the allylic substituent, characteristic of the starting compounds, is preserved, but the signals are shifted by 0.3–0.6 ppm. The absence of proton signals of the trimethyl salt substituent indicates the removal of imide protection under these conditions. The presence of a broade­ned singlet in a weak field indicates the pre­sence of acidic protons. Apparently, protonation does not take place on the alkenyl multiple bonds, but, presumably, on the imide nitrogen atom. Based on elemental analysis, the composition of the formed complex was determined: N-allyl-N-methyl-2,2,2-trichloroethanimidamidine: hexahalogenotelluric acid as 1:0.5, which contains 4 or 3 water molecules. So the interaction of N-allyl-N-methyl-N'-(trimethylsilyl)-2,2,2-trichloroethanimidamide with tellurium tetrahalides in a strongly acidic environment, tellurium- or proton-induced cyclization does not occur, but hexahalogeno­tellurate N-allyl-N-methyl-2,2,2-trichloro­etha­neimidamidinium regardless of the polarity of the solvent.
The safety, efficacy, and functional outcomes on arthroscopic fixation of posterior cruciate ligament avulsion fracture by a bio-absorbable anchor or traditional pull-out technique: A prospective cohort study
Authors: Ren Xiangyu , Wang Jianing , Yang Shulong , Liu Zhe , Wang Tianda , Zhang Teng , Li Haoxin , Zhang Zhong 
Published: November 2022

Background: The posterior cruciate ligament avulsion fracture (PCLAF) is a special type of PCL rupture, and arthroscopic fixation for PCLAF has been recommended currently. The bio-absorbable suture anchor is a novel internal fixation for PCLAF. This study aims to estimate and compare the safety, efficacy, and functional outcomes between the bio-absorbable anchor and the traditional suture pull-out technique for arthroscopic fixation of PCLAF.Methods: This was a prospective cohort study. PCLAF patients were included from 1 January 2020, to 31 August 2021, in our department, and randomly divided into the absorbable anchor group and control group (pull-out suture fixation). Clinical assessments included: post drawer test, gravity test, anterior-posterior laxity (KT-2000), range of motion, Lysholm and International Knee Documentation Committee (IKDC) scores, total failure rate, and returning to sports rate. The minimum follow-up was 1 year (y).Results: 31 patients had accomplished the 1 year follow-up (missing rate: 13.9%). We did not face any complications such as neurovascular injury, fever, infection, un-union, or re-rupture during the follow-up. CT scan showed that all of the patients in the two groups had a well bone union at 3 months in post-operation. At 1 year follow-up, the total failure rate of the bio-absorbable anchor group (1/17, p = 0.036) was lower than the control group (5/14), and the IKDC (86.24 ± 4.35, p = 0.008) and return to sports rate (11/17, p = 0.045) of the bio-absorbable anchor group were higher than that of the control group (81.43 ± 5.06) (4/14).Conclusion: Both the bio-absorbable anchor and suture pull-out technique for arthroscopic fixation of PCLAF have acquired a well bone union and superior safety, but the bio-absorbable anchor group had better efficacy and functional outcomes than the traditional pull-out technique.
Volatile trace metals deposited in ice as soluble volcanic aerosols during the 17.7.ka eruptions of Mt Takahe, West Antarctic Rift
Authors: Mason Emily , Edmonds Marie , McConnell Joseph R. 
Published: November 2022

Volatile metals are emitted at significant rates as gases and particulates from volcanoes, although their speciation, bioreactivity and longevity during atmospheric transport are essentially unknown. Ice cores provide detailed yet largely unexplored long-term records of volcanogenic volatile metals in air and precipitation. Here we evaluate the source and speciation of volatile metals (cadmium, lead, bismuth, and thallium) in Antarctic ice cores from the massive, halogen-rich and sulfur-poor ∼17.7 ka eruptions of Mt. Takahe, West Antarctic Rift. We show that these volatile, chalcophile metals were transported to the ice core as soluble aerosol, derived from magma degassing, in contrast to lithophile elements in the ice core that were transported as silicate ash. We use correlation analysis and chemical speciation modelling of the chlorine-rich volcanic plume to show that the volcanic metals cadmium, lead and bismuth were likely transported as water-soluble chloride aerosols in the atmosphere before they were scavenged from the plume by ice, water or ash and deposited onto the ice within 400 km of the vent. Our findings show that as well as recording trace metals sourced from much more distal regions, ice cores from Antarctica also record clear signatures of regional continental volcanism in the form of chloride aerosol.
Off-shore and underwater sampling of aquatic environments with the aerial-aquatic drone MEDUSA
Authors: Farinha André Tristany , di Tria Julien , Reyes Marta , Rosas Constanca , Pang Oscar , Zufferey Raphael , Pomati Francesco , Kovac Mirko 
Published: November 2022

Monitoring of aquatic habitats for water quality and biodiversity requires regular sampling, often in off-shore locations and underwater. Such sampling is commonly performed manually from research vessels, or if autonomous, is constrained to permanent installations. Consequentially, high frequency ecological monitoring, such as for harmful algal blooms, are limited to few sites and/or temporally infrequent. Here, we demonstrate the use of MEDUSA, an Unmanned Aerial-Aquatic Vehicle which is capable of performing underwater sampling and inspection at up to 10 m depth, and is composed of a multirotor platform, a tether management unit and a tethered micro Underwater Vehicle. The system is validated in the task of vertical profiling of Chlorophyll-a levels in freshwater systems by means of a custom solid sample filtering mechanism. This mechanism can collect up to two independent samples per mission by pumping water through a pair of glass-fibre GF/F filters. Chlorophyll levels measured from the solid deposits on the filters are consistent and on par with traditional sampling methods, highlighting the potential of using UAAVs to sample aquatic locations at high frequency and high spatial resolution.
Ecohydrological features and biodiversity status of estuaries in Bengal delta, Bangladesh: A comprehensive review
Authors: Rakib Md. Refat Jahan , Hossain Mohammad Belal , Islam Mohammad Shahanul , Hossain Iqbal , Rahman Md. Mostafizur , Kumar Rakesh , Sharma Prabhakar 
Published: November 2022

An estuary represents a transition point between freshwater and saltwater and has a complex but productive environment due to a strong interplay between geological, physical, chemical, and biological processes. In Bangladesh, the ecological factors and biodiversity of different estuaries have been investigated for the last 35 years. However, the data is widely scattered, not easily accessible, unpublished, and/or in the form of grey literature. In this study, an attempt has been made to aggregate information available on the geo-environmental and biodiversity status of estuaries for their sustainable management. The biological and environmental data of 21 estuaries along the Bangladesh coast were collected from previously published literature and analyzed. The analyses revealed that the estuarine environment of Bangladesh is very dynamic and diverse like other tropical estuaries. The physico-chemical and geological parameters in estuaries significantly varied due to monsoon patterns, nutrient influx, salinity intrusion, riverine discharge, siltation, and human interventions in estuaries. Among the key environmental variables, such as salinity (3.7–30 ppt), pH (7.04–8), dissolved oxygen (3.30–13.63 mg/L), and water temperature (21–30°C) varied. Over 830 faunal and floral species of 273 genera were recorded from the estuarine environment, including 208 fishes, 87 species of phytoplankton, and 67 species of zooplankton in this region. This study suggests the development of an appropriate policy to protect valuable, productive, and diverse ecosystems, especially for erosion control, pollution abatement, and habitat destruction, particularly in the mangrove forests and their associated habitats of Bangladesh.
A comparative mRNA- and miRNA transcriptomics reveals novel molecular signatures associated with metastatic prostate cancers
Authors: Shinawi Thoraia , Nasser Khalidah Khalid , Moradi Fatima Amanullah , Mujalli Abdulrahman , Albaqami Walaa F. , Almukadi Haifa S. , Elango Ramu , Shaik Noor Ahmad , Banaganapalli Babajan 
Published: November 2022

Background: Prostate cancer (PC) is a fatally aggressive urogenital cancer killing millions of men, globally. Thus, this study aims to identify key miRNAs, target genes, and drug targets associated with prostate cancer metastasis.Methods: The miRNA and mRNA expression datasets of 148 prostate tissue biopsies (39 tumours and 109 normal tissues), were analysed by differential gene expression analysis, protein interactome mapping, biological pathway analysis, miRNA-mRNA networking, drug target analysis, and survival curve analysis.Results: The dysregulated expression of 53 miRNAs and their 250 target genes involved in Hedgehog, ErbB, and cAMP signalling pathways connected to cell growth, migration, and proliferation of prostate cancer cells was detected. The subsequent miRNA-mRNA network and expression status analysis have helped us in narrowing down their number to 3 hub miRNAs (hsa-miR-455-3p, hsa-miR-548c-3p, and hsa-miR-582-5p) and 9 hub genes (NFIB, DICER1, GSK3B, DCAF7, FGFR1OP, ABHD2, NACC2, NR3C1, and FGF2). Further investigations with different systems biology methods have prioritized NR3C1, ABHD2, and GSK3B as potential genes involved in prostate cancer metastasis owing to their high mutation load and expression status. Interestingly, down regulation of NR3C1 seems to improve the prostate cancer patient survival rate beyond 150 months. The NR3C1, ABHD2, and GSK3B genes are predicted to be targeted by hsa-miR-582-5p, besides some antibodies, PROTACs and inhibitory molecules.Conclusion: This study identified key miRNAs (miR-548c-3p and miR-582-5p) and target genes (NR3C1, ABHD2, and GSK3B) as potential biomarkers for metastatic prostate cancers from large-scale gene expression data using systems biology approaches.
Derivation of predicted no-effect concentrations for thirty-five pharmaceuticals and personal care products in freshwater ecosystem
Authors: Fan Hailin , Wang Yuwen , Liu Xiaojuan , Wang Yolina Yu Lin , Kazmi Syed Shabi Ul Hassan , Ohore Okugbe Ebiotubo , Liu Wenhua , Wang Zhen 
Published: November 2022

Pharmaceuticals and personal care products (PPCPs) are contaminants of emerging concern. PPCPs have been detected in various environmental matrices, posing potential threat to human health and environment quality. Thus far, there are no water quality guidelines (WQGs) established for PPCPs for the protection of freshwater organisms and ecosystems. In this study, we used the species sensitivity distribution (SSD) and assessment factor (AF) approaches to derive the 5% hazardous concentrations (HC5) of 35 selected PPCPs using acute and chronic toxicity data. The predicted no-effect concentrations (PNECs) and the acute-to-chronic ratios (ACRs) of chemicals were inherently computed to support the derivation of WQGs and for ecological risk assessment. Among these, endocrine-disrupting chemicals and antipsychotics were shown to pose a greater threat to the freshwater environment and organisms. The highest PNEC was recorded for chloramphenicol (3,620 μg/L) and the lowest for fluoxetine (0.0000291 μg/L), which could have significant ecological risks. In addition, the commonly used default ACRs do not seem to provide adequate support for the prediction of chronic toxicity thresholds and WQGs, as the highest ACRs of these drugs reached 39,100 (e.g., chloramphenicol). The findings of this study provide critical scientific information regarding the development of WQGs for environmental management and the risk control of PPCPs.
Effect of water temperature on embryonic development of Protunus trituberculatus in an off-season breeding mode
Authors: He Jie , Wan Litao , Yu Huaihua , Peng Yingying , Zhang Dongxu , Xu Wenjun 
Published: November 2022

Portunus trituberculatus (swimming crab) is an important breeding crab in China. The current breeding mode of swimming crab is still the traditional “spring seedling and winter harvest” breeding mode. In recent years, researchers have begun to explore a new off-season breeding mode through autumn seedling. In this study, the rate of embryonic development, embryo antioxidant ability and hatching rate of swimming crab in different water temperatures in an off-season breeding mode (breeding in early autumn) and digestive enzyme activity of newly hatched larvae were compared. The results showed that the duration of each development stage of swimming crab embryos was gradually reduced with increasing water temperature. The total development time was 9.43 d at 27°C and only 6.88 d at 33°C. These effects were accompanied by an increase in the development rate from 0.11 d-1 to 0.15 d-1. The total effective accumulated temperature under the 4 temperature conditions was basically maintained at about 150°C·d (147.08 ∼ 153.62°C·d), and there was no significant difference between different groups. The development of embryos at 27°C and 29°C was very synchronous, and no abnormal embryos were observed. Conversely, at 31°C, the later stage of development exhibited asynchrony, and diapause and death were noted in some embryos. At 33°C, more embryos died. The embryo hatching rate was approximately 70% at 27°C and 29°C, and the rate was significantly reduced at 31°C and 33°C. Specifically, the rate was only 13.89% at 33°C. As the water temperature increased, the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) as well as the total antioxidant capacity (T-AOC) and malondialdehyde (MDA) levels of embryos increased first and then decreased, reaching the highest value at 31°C. Catalase (CAT) activity exhibited the opposite trend which was the lowest at 29 °C with a value of only 0.17 U/mg prot and the highest at 33°C with a value of up to 0.51 U/mg prot. At temperatures of 27°C, 29°C and 31°C, the differences in various digestive enzymes of newly hatched larvae primarily manifested as the high activities of pepsin (PEP) and α-amylase (AMS) at 31°C, and other differences were not obvious. At 33°C during embryonic development, the activities of various digestive enzymes were relatively low, especially the activities of trypsin (TPS) and cellulase (CL), which were significantly lower than those of the other three temperature groups. Therefore, judging from the antioxidant index of embryos and the digestive enzyme activity of newly hatched larvae, the embryonic development was still good when the water temperature was 31°C, accompanied by water temperatures above 31°C that seriously affected enzyme activity. Overall, a temperature below 31°C represents the appropriate temperature for embryonic development in autumn in swimming crabs.
Effect of electroacupuncture on the repair of stress ulcer injury in neurocritical patients: A randomized clinical trial
Authors: Li He , Li Li-li , Wang Jian , Wang Yong-qiang , Wang Lan , Yuan Lan , Chen Wen-ting , Song Jian-gang 
Published: November 2022

BackgroundStress ulcer (SU) is one of the main causes of prolonged hospital stay, poor prognosis, and increased mortality in critically ill patients. This study aimed to investigate the effect of electroacupuncture (EA) on SU in patients with severe neurological diseases and explore its possible mechanisms.MethodsTaking patients with SU in adult neurocritical care as the research object, they were randomly divided into the EA group and the control group. Through the perioperative EA intervention, the following indicators were documented: main observation indicator (the effective rate of SU treatment), secondary observation indicators (gastric juice pH, gastric juice occult blood test, and stool occult blood test), related mechanisms [repair factors trefoil factor family 2 (TFF2), vascular endothelial growth factor (VEGF), and heat shock protein 70 (HSP70)], complications during hospitalization, and intensive care unit (ICU) stay time.ResultsCompared with the control treatment, EA increased the effective rate of SU treatment (85.4% for the EA group, 57.5% for the control group, risk difference: 27.9% (95% CI: 8.3%–45.1%); P &lt; 0.01). EA increased the success rate of gastric juice pH treatment on days 1, 2, and 3 (P &lt; 0.01 for day 1, P &lt; 0.05 for days 2 and 3). EA lowered the positive rate of gastric occult blood test on days 1 and 3 (all P-values &lt; 0.05) and the positive rate of fecal occult blood test on day 3 (P &lt; 0.05). EA also reduced the ICU stay time (P &lt; 0.01) and total hospitalization time (P &lt; 0.05). Compared with day 0, all serum repair factors (VEGF, HSP70, and TFF2) of both groups significantly increased on days 1, 3, and 5 (all P-values &lt; 0.01). Compared with the control group, VEGF in the EA group was increased on days 3 and 5 (all P-values &lt; 0.01); HSP70 was increased on days 1, 3, and 5 (P &lt; 0.05 for day 1, P &lt; 0.01 for days 3 and 5); and TFF2 was increased on days 1, 3, and 5 (all P-values &lt; 0.01).ConclusionElectroacupuncture promoted the repair of SU damage in severe neurological disease, and its effect was related to enhancing the expression of gastric mucosal repair factors.Clinical trial registration[https://www.chictr.org.cn/showprojen.aspx?proj=127012], identifier [ChiCTR2100046701].