bluuebunny/crossref_metadata_2025_split huggingface dataset:
Malignant mixed mullerian tumor: A case report about a uterine Tumor's case
Authors: Morgan Emmanuel D. , Okecha Tony , Yahaya James J. , Othieno Emmanuel 
Published: May 2022

ABSTRACT

Introduction:
Malignant mixed Mullerian tumor (MMMT) is an exceedingly rare and aggressive tumor which occurs predominantly in postmenopausal women though it has been reported rarely in premenopausal women.

Case presentation:
A 54-year old nulliparous postmenopausal female presented with a 3-month history of vaginal bleeding, mild lower abdominal pain and weight loss. Ultrasound revealed markedly enlarged uterus with a hyper-echoic solid and cystic mass and a right adnexal complex mass. Total abdominal hysterectomy and bilateral salpingioopherectomy were done. Histopathological features were consistent with MMMT. The patient is currently stable after 6 cycles of adjuvant chemotherapy which consisted of paclitaxel and carboplatin.

Clinical discussion:
MMMT of the uterus is rare, high-grade neoplasms comprising only 1–2% of uterine cancers and 3–5% of all uterine malignancies. This tumor may arise in the ovaries, fallopian tubes and vagina. Histologically, MMMT is a biphasic tumor composed of both epithelial (carcinoma) elements and mesenchymal (sarcoma) elements; though, which component is responsible for the tumor's aggressive biological behavior remains undetermined.

Conclusion:
MMMT is a rare and aggressive tumor which is commonly seen in postmenopausal women with high rate of recurrence therefore, Radical surgery and close follow-up is mandatory since the role of chemoradiotherapy remains unclear in the management of patients with this tumor. Both stage of the tumor and myometrial invasion are considered as potential prognostic factors.

Highlights
Rules of Origin in International Trade
Authors: Inama Stefano 
Published: May 2022

This book provides comprehensive, in-depth analysis of the different sets of rules of origin adopted by major trading partners and worldwide, as well as efforts to establish multilateral rules at WTO and WCO. It discusses the status of non-preferential as well as preferential rules of origin in international trade, their evolution during the last decades and their tendencies and future. With its multidisciplinary approach, this book's contents provide comparative analysis of the relevant legal and economic features of different rules origin compilation sets, reviewing their drafting differences and their implications and impact on the economic and industrial environments. This edition has been updated and expanded to include the latest developments on rules of origin at multilateral level in WTO and WCO and on rules of origin in recent FTAs. Drawing from his thirty years of experience, Stefano Inama provides insights from trade negotiations along with practical tools for policy makers and practitioners, orientation for the private sector and analytical tools for researchers.
Testing the Drugs’ Sentencing Guidelines: A Comparison between England and Wales and Hong Kong
Authors: Cheng Kevin Kwok-Yin , Ri Sayaka , Pushkarna Natasha 
Published: May 2022

AbstractIn the era of sentencing guidelines, the punishment for traffickers is primarily based on the offenders’ culpability and the drug weight. Existing literature tend to focus on the issue of proportionality as it relates to the roles and culpability of offenders. However, little attention has been drawn to the quantity of drugs. England and Wales have incorporated offender roles into their sentencing guidelines, while Hong Kong uses drug tariffs strictly based on drug weight to calculate the starting point of a sentence. Using a novel equation called ‘the arithmetic starting point of sentence’, this study examines the starting sentence based on each gram of drugs by undertaking a comparative analysis of the respective jurisdictions. The results show that both jurisdictions have adopted sentencing guidelines that exhibit a logarithmic curve. This implies that the scale used to measure the quantity of drugs is disproportionate, penalising smaller quantities more harshly than larger quantities.
Evidence-based practice strategies for faculty professional development in clinical translational research at Institutional Development Award (IDeA) state institutions in the Mountain West
Authors: Kataoka-Yahiro Merle R. , Myaskovsky Larissa , Dagda Ruben K. , Sood Akshay , Conway Kathrene , Lopez Joseph Guerrero , Burge Mark R. , Sy Francisco S. 
Published: May 2022

Abstract
The Mountain West Clinical Translational Research – Infrastructure Network (MW CTR-IN), established in 2013, is a research network of 13 university partners located among seven Institutional Development Award (IDeA) states targeting health disparities. This is an enormous undertaking because of the size of the infrastructure network (encompassing a third of the US landmass and spanning four time zones in predominantly rural and underserved areas, with populations that have major health disparities issues). In this paper, we apply the barriers, strategies, and metrics to an adapted educational conceptual model by Fink (2013). Applying this model, we used four tailored approaches across this regional infrastructure network to: (1) assess individual faculty specific needs, (2) reach out and engage with faculty, (3) provide customized services to meet the situational needs of faculty, and (4) utilize a “closed communication feedback loop” between Professional Development (PD) core and MW CTR-IN faculty within the context of their home institutional environment. Summary statement results from participating faculty show that these approaches were positive. Grounded in best educational practice approaches, we have an opportunity to refine and build from this sound foundation with implications for future use in other CTR-IN networks and institutions in the IDeA states.
The zero mass problem for Klein-Gordon equations: quadratic null interactions
Authors: Dong Shijie 
Published: May 2022

Abstract
We study in

$\mathbb {R}^{3+1}$

a system of nonlinearly coupled Klein-Gordon equations under the null condition, with (possibly vanishing) mass varying in the interval

$[0, 1]$

. Our goal is three-fold, which extends the results in the earlier work of [5, 3]: 1) we want to establish the global well-posedness result to the system that is uniform in terms of the mass parameter (i.e., the smallness of the initial data is independent of the mass parameter); 2) we want to obtain a unified pointwise decay result for the solution to the system, in the sense that the solution decays more like a wave component (independent of the mass parameter) in a certain range of time, while the solution decays as a Klein-Gordon component with a factor depending on the mass parameter in the other part of the time range; 3) the solution to the Klein-Gordon system converges to the solution to the corresponding wave system in a certain sense when the mass parameter goes to 0. In order to achieve these goals, we will rely on both the flat and hyperboloidal foliation of the spacetime and prove a mass-independent

$L^2$

–type energy estimate for the Klein-Gordon equations with possibly vanishing mass. In addition, the case of the Klein-Gordon equations with certain restricted large data is discussed.
Validating the Applicability of Bayesian Inference with Surname and Geocoding to Congressional Redistricting
Authors: DeLuca Kevin , Curiel John A. 
Published: May 2022

AbstractEnsuring descriptive representation of racial minorities without packing minorities too heavily into districts is a perpetual difficulty, especially in states lacking voter file race data. One advance since the 2010 redistricting cycle is the advent of Bayesian Improved Surname Geocoding (BISG), which greatly improves upon previous ecological inference methods in identifying voter race. In this article, we test the viability of employing BISG to redistricting under two posterior allocation methods for race assignment: plurality versus probabilistic. We validate these methods through 10,000 redistricting simulations of North Carolina and Georgia’s congressional districts and compare BISG estimates to actual voter file racial data. We find that probabilistic summing of the BISG posteriors significantly reduces error rates at the precinct and district level relative to plurality racial assignment, and therefore should be the preferred method when using BISG for redistricting. Our results suggest that BISG can aid in the construction of majority-minority districts during the redistricting process.
Isoleucine stimulates mTOR and SREBP-1c gene expression for milk synthesis in mammary epithelial cells through BRG1-mediated chromatin remodelling
Authors: Hao Qi , Wang Zhe , Wang Lulu , Han Meihong , Zhang Minghui , Gao Xuejun 
Published: May 2022

AbstractSeveral amino acids can stimulate milk synthesis in mammary epithelial cells (MEC); however, the regulatory role of isoleucine (Ile) and underlying molecular mechanism remain poorly understood. In this study, we aimed to evaluate the regulatory effects of Ile on milk protein and fat synthesis in MEC and reveal the mediation mechanism of Brahma-related gene 1 (BRG1) on this regulation. Ile dose dependently affected milk protein and fat synthesis, mechanistic target of rapamycin (mTOR) phosphorylation, sterol regulatory element binding protein 1c (SREBP-1c) expression and maturation, and BRG1 protein expression in bovine MEC. Phosphatidylinositol 3 kinase (PI3K) inhibition by LY294002 treatment blocked the stimulation of Ile on BRG1 expression. BRG1 knockdown and gene activation experiments showed that it mediated the stimulation of Ile on milk protein and fat synthesis, mTOR phosphorylation, and SREBP-1c expression and maturation in MEC. ChIP-PCR analysis detected that BRG1 bound to the promoters of mTOR and SREBP-1c, and ChIP-qPCR further detected that these bindings were increased by Ile stimulation. In addition, BRG1 positively regulated the binding of H3K27ac to these two promoters, while it negatively affected the binding of H3K27me3 to these promoters. BRG1 knockdown blocked the stimulation of Ile on these two gene expressions. The expression of BRG1 was higher in mouse mammary gland in the lactating period, compared with that in the puberty or dry period. Taken together, these experimental data reveal that Ile stimulates milk protein and fat synthesis in MEC via the PI3K-BRG1-mTOR/SREBP-1c pathway.
Association between pre-conceptional carbohydrate quality index and the incidence of gestational diabetes: the SUN cohort study
Authors: Fernández-González Elena , Martínez-González Miguel Á. , Bes-Rastrollo Maira , Suescun-Elizalde David , Basterra-Gortari Francisco Javier , Santiago Susana , Gea Alfredo 
Published: May 2022

AbstractThe aim of the study was to investigate the association between pre-gestational carbohydrate quality index (CQI) and the incidence of gestational diabetes mellitus (GDM). Data from the ‘Seguimiento Universidad de Navarra’ (SUN) cohort were used, which includes 3827 women who notified at least one pregnancy between December 1999 and December 2019. We used a validated semi-quantitative 136-item FFQ to evaluate dietary exposures at baseline and at 10-year follow-up. The CQI was defined by four criteria: glycaemic index, whole-grain/total-grain carbohydrate, dietary fibre intake and solid/total carbohydrate ratio. We fitted generalised estimating equations with repeated measurements of the CQI to assess its relationship with incident GDM. A total of 6869 pregnancies and 202 new cases of incident GDM were identified. The inverse association between the global quality of carbohydrate and the development of GDM was not statistically significant: OR the highestv. the lowest CQI category: 0·67, 95 % CI (0·40, 1·10),Pfor trend= 0·10. Participants at the highest CQI category and with daily carbohydrate amounts ≥50 % of total energy intake had the lowest incidence of GDM (OR = 0·29 (95 % CI (0·09, 0·89)) compared with those with the lowest quality (lowest CQI) and quantity (≤40 %). Further studies are needed to overcome the limitations of our study. Those studies should jointly consider the quality and the quantity of dietary carbohydrates, as the quality might be of importance, especially in women with a higher intake of carbohydrates.
Intestinal parasites in the Neolithic population who built Stonehenge (Durrington Walls, 2500 BCE)
Authors: Mitchell Piers D. , Anastasiou Evilena , Whelton Helen L. , Bull Ian D. , Parker Pearson Mike , Shillito Lisa-Marie 
Published: May 2022

AbstractDurrington Walls was a large Neolithic settlement in Britain dating around 2500 BCE, located very close to Stonehenge and likely to be the campsite where its builders lived during its main stage of construction. Nineteen coprolites recovered from a midden and associated pits at Durrington Walls were analysed for intestinal parasite eggs using digital light microscopy. Five (26%) contained helminth eggs, 1 with those of fish tapeworm (likelyDibothriocephalus dendriticus) and 4 with those of capillariid nematodes. Analyses of bile acid and sterol from these 5 coprolites show 1 to be of likely human origin and the other 4 to likely derive from dogs. The presence of fish tapeworm reveals that the Neolithic people who gathered to feast at Durrington Walls were at risk of infection from eating raw or undercooked freshwater fish. When the eggs of capillariids are found in the feces of humans or dogs it normally indicates that the internal organs (liver, lung or intestines) of animals with capillariasis have been eaten, and eggs passed through the gut without causing disease. Their presence in multiple coprolites provides new evidence that internal organs of animals were consumed. These novel findings improve our understanding of both parasitic infection and dietary habits associated with this key Neolithic ceremonial site.
General overview of the current status of human foodborne trematodiasis
Authors: Chai Jong-Yil , Jung Bong-Kwang 
Published: May 2022

AbstractFoodborne trematodes (FBT) of public health significance include liver flukes (Clonorchis sinensis, Opisthorchis viverrini, O. felineus, Fasciola hepaticaandF. gigantica), lung flukes (Paragonimus westermaniand several otherParagonimusspp.) and intestinal flukes, which include heterophyids (Metagonimus yokogawai, Heterophyes nocensandHaplorchis taichui), echinostomes (Echinostoma revolutum, Isthmiophora hortensis, Echinochasmus japonicusandArtyfechinostomum malayanum) and miscellaneous species, includingFasciolopsis buskiandGymnophalloides seoi. These trematode infections are distributed worldwide but occur most commonly in Asia. The global burden of FBT diseases has been estimated at about 80 million, however, this seems to be a considerable underestimate. Their life cycle involves a molluscan first intermediate host, and a second intermediate host, including freshwater fish, crustaceans, aquatic vegetables and freshwater or brackish water gastropods and bivalves. The mode of human infection is the consumption of the second intermediate host under raw or improperly cooked conditions. The major pathogenesis ofC. sinensisandOpisthorchisspp. infection includes inflammation of the bile duct which leads to cholangitis and cholecystitis, and in a substantial number of patients, serious complications, such as liver cirrhosis and cholangiocarcinoma, may develop. In lung fluke infections, cough, bloody sputum and bronchiectasis are the most common clinical manifestations. However, lung flukes often migrate to extrapulmonary sites, including the brain, spinal cord, skin, subcutaneous tissues and abdominal organs. Intestinal flukes can induce inflammation in the intestinal mucosa, and they may at times undergo extraintestinal migration, in particular, in immunocompromised patients. In order to control FBT infections, eating foods after proper cooking is strongly recommended.
Feasibility study to characterize price and reimbursement decision-making criteria for the inclusion of new drugs in the Spanish National Health System: the cefiderocol example
Authors: Calleja Miguel Ángel , Badia Xavier 
Published: May 2022

Abstract

Objectives
The reimbursement of medicines by the Spanish National Health System (NHS) is based on a set of criteria included in the Royal Legislative Decree 1/2015 (RDL 1/2015). The Interministerial Committee on Pricing of Medicines and Healthcare Products (CIPM) is responsible for the final price and reimbursement (P&R) decision, including on its resolutions the criteria listed in the law by which the reimbursement of a drug is approved or denied. Nevertheless, the information behind its reasoning is not provided. The present study aims to characterize the P&R criteria of the RDL 1/2015 through criteria definitions from other countries to improve the P&R evaluation in Spain.

Results
A multidisciplinary experts panel with relevant experience in drug evaluation and decision making at national, regional, and local level in Spain was selected for this study. A literature review to characterize the criteria listed in the RDL 1/2015 was performed based on the most relevant and recognized Health Technology Assessment (HTA) agencies in Europe, UK, and Canada. Eventually, a feasibility study was performed to evaluate the novel drug cefiderocol using the characterized criteria, including a reflective discussion of the results.

Conclusions
Consensus was reached among the multidisciplinary experts on the characterization of the criteria set by the law. The feasibility of their application to a new drug was exploratory, notwithstanding it showed the potential to improve the transparency as well as to offer a more structured rationale for the CIPM to evaluate the inclusion of new drugs in the Spanish NHS.
The Heritability of Twinning in Seven Large Historic Pedigrees
Authors: Duffy David L. , Martin Nicholas G. 
Published: May 2022

AbstractIt is widely recognized that dizygotic twinning (DZT) runs in families, but estimates of heritability from twin and family data are remarkably scarce and vary considerably. Here, we traced seven large, sometimes historical, multigeneration pedigrees from West Africans, fin de siècle French Jews, Canadians (two pedigrees), and the French royal family, in which twin births were recorded. We estimated heritability of twinning (of all types) as zygosity information was not available, diluting the true DZT heritability by a third or so. The estimates in the range 8−20% are remarkably consistent across time (8−19 generations) and ethnicities and also consistent with twin and family estimates.
Evidence of Alfvénic Activity in Jupiter's Mid‐To‐High Latitude Magnetosphere
Authors: Lorch C. T. S. , Ray L. C. , Wilson R. J. , Bagenal F. , Crary F. , Delamere P. A. , Damiano P. A. , Watt C. E. J. , Allegrini F. 
Published: May 2022

AbstractUsing a combination of Juno magnetometer and plasma data, we show evidence of Alfvénic turbulence within the mid‐to‐high latitude magnetosphere with sufficient conditions to trigger auroral particle acceleration. We analyze 12 events that, in agreement with theoretical results, are found to be dissipative at the electron inertial scale. Furthermore, these events contain significant Poynting flux in the range ∼0.8–20 mW/m2 at ionospheric altitudes. This is sufficient to generate auroral emissions. We confirm that such events are incompressible, confirming their Alfvénicity, occur at dissipative scales, have intermittent features present and are multifractal in nature. These results illustrate the importance of turbulence in the mid‐to‐high latitudes of Jupiter's magnetosphere as a driver of particle acceleration.
Age and Rate of Accumulation of Metal‐Rich Hydrothermal Deposits on the Seafloor: The Lucky Strike Vent Field, Mid‐Atlantic Ridge
Authors: Sánchez‐Mora Dennis , Jamieson John , Cannat Mathilde , Escartín Javier , Barreyre Thibaut 
Published: May 2022

AbstractHydrothermal venting at the Lucky Strike hydrothermal field, located on the Mid‐Atlantic Ridge, is associated with faulting linked to the tectonic dismemberment of a central axial volcano. Radium‐226/Ba dating of hydrothermal barite indicates that hydrothermal venting is at least 6,600 years old, and that Lucky Strike is one of the youngest known vent fields on the Mid‐Atlantic Ridge, which typically have ages exceeding 20 ka. Deposit volume calculations indicate that the total accumulated mass of the hydrothermal deposits on the seafloor at Lucky Strike is ∼1.3 ± 0.2 Mt, and that this mass accumulated at a maximum average rate of 194 ± 28 t/yr. This accumulation rate is comparable to other well characterized mid‐ocean ridge hydrothermal sites, such as TAG and Endeavor, but at Lucky Strike is concentrated within a relatively small area of <2.5 km2.
Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells
Authors: Fan Liang-Liang , Du Ran , Liu Ji-Shi , Jin Jie-Yuan , Wang Chen-Yu , Dong Yi , He Wan-Xia , Yan Ri-Qiang , Xiang Rong 
Published: May 2022

AbstractReticulon 3 (RTN3) is an endoplasmic reticulum protein that has previously been shown to play roles in neurodegenerative diseases, but little is known about its function in the kidneys. The aim of the present study was to clarify the roles of RTN3 in chronic kidney disease (CKD) and kidney fibrosis. In this study, RTN3 levels were measured in kidney tissues from healthy controls and CKD or kidney fibrosis patients. An RTN3-null mouse model was generated to explore the pathophysiological roles of RTN3 in the kidneys. The underlying mechanisms were studied in primary proximal tubular epithelial cells and HEK293 cells in vitro. The results showed that (1) a reduction in RTN3 in mice induces CKD and kidney fibrosis; (2) decreased RTN3 expression is found in patients with CKD; (3) RTN3 plays critical roles in regulating collagen biosynthesis and mitochondrial function; and (4) mechanistically, RTN3 regulates these phenotypes by interacting with GC-Rich Promoter Binding Protein 1 (GPBP1), which activates the IGF2-JAK2-STAT3 pathway. Our study indicates that RTN3 might play crucial roles in CKD and kidney fibrosis and that a reduction in RTN3 in the kidneys might be a risk factor for CKD and kidney fibrosis.