bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short‐ and long‐term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity
Authors: Kvitne Kine Eide , Krogstad Veronica , Wegler Christine , Johnson Line Kristin , Kringen Marianne K. , Hovd Markus Herberg , Hertel Jens K. , Heijer Maria , Sandbu Rune , Skovlund Eva , Artursson Per , Karlsson Cecilia , Andersson Shalini , Andersson Tommy B. , Hjelmesæth Jøran , Åsberg Anders , Jansson‐Löfmark Rasmus , Christensen Hege , Robertsen Ida 
Published: April 2022

AimRoux‐en‐Y gastric bypass (RYGB) may influence drug disposition due to surgery‐induced gastrointestinal alterations and/or subsequent weight loss. The objective was to compare short‐ and long‐term effects of RYGB and diet on the metabolic ratios of paraxanthine/caffeine (cytochrome P450 [CYP] 1A2 activity), 5‐hydroxyomeprazole/omeprazole (CYP2C19 activity) and losartan/losartan carboxylic acid (CYP2C9 activity), and cross‐sectionally compare these CYP‐activities with normal‐to‐overweight controls.MethodsThis trial included patients with severe obesity preparing for RYGB (n = 40) or diet‐induced (n = 41) weight loss, and controls (n = 18). Both weight loss groups underwent a 3‐week low‐energy diet (<1200 kcal/day, weeks 0‐3) followed by a 6‐week very‐low‐energy diet or RYGB (both <800 kcal/day, weeks 3‐9). Follow‐up time was 2 years, with four pharmacokinetic investigations.ResultsMean ± SD weight loss from baseline was similar in the RYGB‐group (13 ± 2.4%) and the diet group (10.5 ± 3.9%) at week 9, but differed at year 2 (RYGB −30 ± 6.9%, diet −3.1 ± 6.3%). From weeks 0 to 3, mean (95% confidence interval [CI]) CYP2C19 activity similarly increased in both groups (RYGB 43% [16, 55], diet 48% [22, 60]). Mean CYP2C19 activity increased by 30% (2.6, 43) after RYGB (weeks 3‐9), but not in the diet‐group (between‐group difference −0.30 [−0.63, 0.03]). CYP2C19 activity remained elevated in the RYGB group at year 2. Baseline CYP2C19 activity was 2.7‐fold higher in controls compared with patients with obesity, whereas no difference was observed in CYP1A2 and CYP2C9 activities.ConclusionOur findings suggest that CYP2C19 activity is lower in patients with obesity and increases following weight loss. This may be clinically relevant for drug dosing. No clinically significant effect on CYP1A2 and CYP2C9 activities was observed.
Using Personal‐Disclosure Mutual‐Sharing (PDMS) with first‐year undergraduate students transitioning to higher education
Authors: Evans Andrew L. , Slater Matthew J. , Turner Martin J. 
Published: April 2022

AbstractBackgroundUsing Personal‐Disclosure Mutual‐Sharing (PDMS) with students transitioning to Higher Education (HE) has yet to be researched in education.AimsIn two studies, we aimed to explore the immediate effects of a Coping Oriented Personal‐Disclosure Mutual‐Sharing (COPDMS) intervention on first‐year undergraduate students’ relational and organizational identification, perceived social support availability, and self‐efficacy for learning and performance. In our second study, we also aimed to examine student‐perceptions of participating in a COPDMS intervention.Sample and MethodsAt the beginning of induction week in both studies, first‐year undergraduate students on the same degree programme at a HE provider in England received an education session where COPDMS was introduced. Students participated in a COPDMS session a few days later. During COPDMS sessions, students mutually‐shared and disclosed personal information and/or stories relating to transitional experiences.ResultsAcross both studies, students’ relational identification with staff and perceived emotional, esteemed, and informational support availability from others on the degree programme significantly increased from pre‐ to post‐COPDMS phases. Findings relating to relational identification with other Year 1 students and perceived availability of tangible support were mixed. No significant changes occurred for organizational identification with the university and self‐efficacy for learning and performance. In Study 2, five higher‐order themes relating to students’ perceptions of COPDMS were found: (1) emotionality; (2) personal development; (3) storytelling; (4) enhanced group processes; and (5) task appropriateness and value.ConclusionsStudy findings provide evidence that COPDMS is a useful psychological intervention to deliver to students transitioning to HE. Practical considerations, limitations, and future research suggestions are provided.
Innovation energy: The stimulus converting employees' innovation properties into innovative work behaviour
Authors: van Essen Henk Jan , de Leede Jan , Bondarouk Tanya 
Published: April 2022

Anticipating the post‐Covid‐19 period, the need for innovation remains urgent, with the innovative work behaviour (IWB) exhibited by employees being a crucial aspect. Since Scott and Bruce (1994) wrote about this behaviour, many IWB‐related factors have been found. In this study, we distinguished various employees' personal innovation properties as IWB‐related factors: creativity, psychological empowerment, optimism and work‐contextual factors like room for autonomy, leadership, multidisciplinary innovative teamwork and external contacts. In our qualitative research within two innovative Dutch companies (Philips and Topicus), we interviewed 49 employees, most with a high degree of IWB, and their 22 managers to uncover the relation between the factors and IWB. Earlier research provided rich information about IWB and its factors, mostly from an organizational viewpoint. Our research focuses on the employees themselves, who are showing IWB. We assumed at the start of our research that in addition to these factors, there must be an overall energetic stimulus, because innovation is a process with many obstacles. Therefore, we introduce the concept of innovation energy, which converts employees' innovation properties into innovative work behaviour. This outcome can be used in further research and in the managerial and HRM practice.
Developmental foundations of physiological dynamics among mother–infant dyads: The role of newborn neurobehavior
Authors: Gao Mengyu (Miranda) , Speck Bailey , Ostlund Brendan , Neff Dylan , Shakiba Nila , Vlisides‐Henry Robert D. , Kaliush Parisa R. , Molina Nicolette C. , Thomas Leah , Raby K. Lee , Crowell Sheila E. , Conradt Elisabeth 
Published: April 2022

AbstractThis study tested whether newborn attention and arousal provide a foundation for the dynamics of respiratory sinus arrhythmia (RSA) in mother–infant dyads. Participants were 106 mothers (Mage = 29.54) and their 7‐month‐old infants (55 males and 58 White and non‐Hispanic). Newborn attention and arousal were measured shortly after birth using the NICU Network Neurobehavioral Scale. Higher newborn arousal predicted a slower return of infant RSA to baseline. Additionally, greater newborn attention predicted mothers’ slower return to baseline RSA following the still‐face paradigm, and this effect only held for mothers whose infants had lower newborn arousal. These findings suggest that newborn neurobehavior, measured within days of birth, may contribute to later mother–infant physiological processes while recovering from stress.
‘Sentí que Alguien Murió’ (‘I felt someone died’): Ambiguous loss in the face of parental deportation
Authors: Taschman Katrina , Muruthi Bertranna A. , Thompson Cañas Reid E. , Romero Lindsey 
Published: April 2022

AbstractOver 16 million people in the United States belong to a mixed‐status family in which at least one member of their household is undocumented. The current study will explore adult reflections on childhood experiences of parental deportation in order to elucidate their meaning of the loss and if their experiences resemble an ambiguous loss. Interpretative Phenomenological Analysis was utilized to analyse in‐depth retrospective meaning‐making narratives of adult children who lost a parent to deportation. Findings indicate that the children of detained or deported parents experienced difficulty not knowing what was happening, believed their parents would return, and noted family practices that they found to be helpful or unhelpful in processing their loss.
Real geo‐time‐based secured access computation model for e‐Health systems
Authors: Kumar Ajay , Abhishek Kumar , Chakraborty Chinmay , Rodrigues Joel J. P. C. 
Published: April 2022

AbstractRole Back Access Control model (RBAC) allows devices to access cloud services after authentication of requests. However, it does not give priority in Big Data to devices located in certain geolocations. Regarding the crisis in a specific region, RBAC did not provide a facility to give priority access to such geolocations. In this paper, we planned to incorporate Location Time‐ (GEOTime) based condition alongside Priority Attribute role‐based access control model (PARBAC), so requesters can be allowed/prevented from access based on their location and time. The priority concept helped to improve the performance of the existing access model. TIME‐PARBAC also ensures service priorities based on geographical condition. For this purpose, the session is encrypted using a secret key. The secret key is created by mapping location, time, speed, acceleration and other information into a unique number, that is, K(Unique_Value) = location, time, speed, accelerator, other information. Spatial entities are used to model objects, user position, and geographically bounded roles. The role is activated based on the position and attributes of the user. To enhance usability and flexibility, we designed a role schema to include the name of the role and the type of role associated with the logical position and the rest of the PARBAC model proposed using official documentation available on the website for Azure internet of things (IoT) Cloud. The implementation results utilizing a health use case signified the importance of geology, time, priority and attribute parameters with supporting features to improve the flexibility of the existing access control model in the IoT Cloud.
Path‐finding algorithm as a dispersal assessment method for invasive species with human‐vectored long‐distance dispersal event
Authors: Lee Sung‐Joo , Cho Hyojin , Choi Yuyoung , Choi Won Il , Chung Hye In , Lim No Ol , Nam Youngwoo , Jeon Seongwoo 
Published: April 2022

AbstractAimAn assessment method that can precisely represent human‐vectored long‐distance dispersals (HVLDD) is currently in need for the effective management of invasive species. Here, we focussed on HVLDD happening along roads and proposed a path‐finding algorithm as a more precise dispersal assessment tool than the most widely used Euclidean distance method by using pine wilt disease (PWD) as a case study.LocationBusan Metropolitan City, Republic of Korea.MethodsA path‐finding algorithm, which calculates distances by considering the spatial distribution of road networks, was tested for its effectiveness in estimating dispersal distances of HVLDD events. To this end, annual HVLDD cases were classified from entire PWD occurrence data from 2016 to 2019, and their dispersal distances were calculated using the path‐finding algorithm and the Euclidean distance method. We constructed potential dispersal ranges based on the occurrence points in 2016, 2017 and 2018 using the respective year's mean dispersal distance for both methods, and their performances in accounting for each subsequent year's HVLDD cases were compared to determine which method calculated more precise distances. The information on which road class contributed more to dispersal occurrences and distances was analysed as well using the proposed algorithm.ResultsThe potential dispersal ranges of the path‐finding algorithm accounted for more future anthropogenic infection cases than the ones that used the Euclidean distance method, validating its higher functionality. It also revealed that most HVLDDs started and ended on small roads, and large roads constituted the majority of the total dispersal length.Main conclusionsThe path‐finding algorithm has proven to be a more effective dispersal assessment method for HVLDD events. It can help design effective control strategies. Thus, we encourage using the path‐finding algorithm for the dispersal assessment of invasive species that move along road networks, and for the development of more powerful HVLDD prediction models.
Revascularization strategies for patients with established chronic coronary syndrome
Authors: Coerkamp Casper F. , Hoogewerf Marieke , van Putte Bart P. , Appelman Yolande , Doevendans Pieter A. 
Published: April 2022

AbstractCoronary artery disease is the most common type of cardiovascular disease, leading to high mortality rates worldwide. Although the vast majority can be treated effectively and safely by medical therapy, revascularization strategies remain essential for numerous patients. Outcomes of both percutaneous coronary intervention and coronary artery bypass grafting improve in a rapid pace, resulting from technical innovation and ongoing research. Progress has been achieved by technical improvements in coronary stents, optimal coronary target and graft selection, and the availability of minimally invasive surgical strategies. Besides technical progress, evidence‐based patient‐tailored decision‐making by the Heart Team is the basic precondition for optimal outcome. The combination of fast innovation and long‐term clinical evaluations creates a dynamic field. Research outcomes should be carefully interpreted according to the techniques used and the trial's design. Therefore, more and more trial outcomes suggest that revascularization strategies should be tailored towards the specific patient. Although the European Society of Cardiology/European Association for Cardio‐Thoracic Surgery guidelines on myocardial revascularization date from 2018 and a large variety of trial outcomes on revascularization strategies in chronic coronary syndrome have been published since, we aim to provide an updated overview within this review.
Growth and canopy traits affected by myrtle rust (Austropuccinia psidii Winter) in Eucalyptus grandis x Eucalyptus urophylla
Authors: Hakamada Rodrigo , da Silva Renato Meulman Leite , Moreira Gabriela Gonçalves , Teixeira José Da Silva , Takahashi Simone , Masson Marcus Vinicius , Ferreira Karina Zamprogno , Fernandes Pietro Gragnolati , Martins Sarah Diniz Silva 
Published: April 2022

AbstractAustropuccinia psidii Winter, causal agent of myrtle rust, is one of the main pathogens in Eucalyptus plantations in Brazil. We investigated the effects of the pathogen on wood yield and light use efficiency (LUE) in a Eucalyptus grandis x Eucalyptus urophylla clone in a field trial at the end of a five‐year rotation. The study comprised two treatments that are commonly adopted by managers. One treatment with curative fungicide spray (Triadimenol 250 g l−1) seven months after planting and another with five preventive sprays of the same fungicide, from the 1st to 7th month age of saplings. At 5 years old, the control plots attained a mean annual increment of 35 m³ ha−1 yr−1, the curative and preventive treatments were 39 and 47 m³ ha−1 yr−1 (11% and 34% higher, respectively). LUE was also higher when fungicides were applied, 8% and 26% higher in curative and preventive treatments (1.06 and 1.24 g MJ−1) compared with the control plots (0.98 g MJ−1). To confirm the negative effect of rust at a larger scale, we tracked 102 inventory plots (from 1,234 ha) from 2 to 6 years old with the same clone, half infected and half with rust corrective control. Growth difference decreased with time, from an average of 41% at age 2%–5% at age 6. These results highlight the importance of managing myrtle rust in Eucalyptus plantations by selecting a disease‐tolerant genotype or adopting other strategies for disease control.
Ascertaining land allocation decisions of farmers about the adoption of carinata as a potential crop for sustainable aviation fuel production in the Southern United States
Authors: Ullah Kazi Masel , Dwivedi Puneet 
Published: April 2022

AbstractThe adoption of a bioenergy crop is affected by various factors, including but not limited to the characteristics of farmers, farm economics, market forces, and physical environment. This study develops a spatially explicit agent‐based model for ascertaining the adoption rate of carinata (Brassica carinata) among the farmers in the Little River Experimental Watershed located in the southern state of Georgia in the United States. Each farmer's adoption behavior is modeled using the profitability difference between traditional crop rotations (with and without carinata at different contract prices), the adoption rate of neighboring farmers, and their land allocation decisions from managing a risky portfolio of enterprises. Carinata production in the winter season once every 3 years has no conflict with the most profitable and popular traditional row crop rotations, such as cotton‐cotton‐cotton and cotton‐cotton‐peanut, to a larger extent. The results show that 28% and 85% of farmers in the watershed will adopt carinata after 33 years at a contract price of $13/bushel (bu) under two different assumptions of low (2.5%) and high (5%) initial neighborhood adoption rates. The proportions of land allocated to carinata to the total farmland under field crops are 38% and 85% after 33 years under the same low and high neighborhood adoption rates, respectively. Our results suggest that fixing the appropriate contract price of carinata will bring additional profits to farmers without any significant foreseeable agronomic risks, thereby increasing the adoption rate of carinata at a regional level.
T cell‐intrinsic miR‐155 is required for Th2 and Th17‐biased responses in acute and chronic airway inflammation by targeting several different transcription factors
Authors: Kim Hyo Jin , Park Seong Ok , Byeon Hee Won , Eo Jun Cheol , Choi Jin Young , Tanveer Maryum , Uyangaa Erdenebelig , Kim Koanhoi , Eo Seong Kug 
Published: April 2022

AbstractAsthmatic airway inflammation is divided into two typical endotypes: Th2‐mediated eosinophilic and Th1‐ or Th17‐mediated neutrophilic airway inflammation. The miRNA miR‐155 has well‐documented roles in the regulation of adaptive T‐cell responses and innate immunity. However, no specific cell‐intrinsic role has yet been elucidated for miR‐155 in T cells in the course of Th2‐eosinophilic and Th17‐neutrophilic airway inflammation using actual in vivo asthma models. Here, using conditional KO (miR155ΔCD4 cKO) mice that have the specific deficiency of miR‐155 in T cells, we found that the specific deficiency of miR‐155 in T cells resulted in fully suppressed Th2‐type eosinophilic airway inflammation following acute allergen exposure, as well as greatly attenuated the Th17‐type neutrophilic airway inflammation induced by repeated allergen exposure. Furthermore, miR‐155 in T cells appeared to regulate the expression of several different target genes in the functional activation of CD4+ Th2 and Th17 cells. To be more precise, the deficiency of miR‐155 in T cells enhanced the expression of c‐Maf, SOCS1, Fosl2 and Jarid2 in the course of CD4+ Th2 cell activation, while C/EBPβ was highly enhanced in CD4+ Th17 cell activation in the absence of miR‐155 expression. Conclusively, our data revealed that miR‐155 could promote Th2 and Th17‐mediated airway inflammation via the regulation of several different target genes, depending on the context of asthmatic diseases. Therefore, these results provide valuable insights into actual understanding of specific cell‐intrinsic role of miR‐155 in eosinophilic and neutrophilic airway inflammation for the development of fine‐tune therapeutic strategies.
Simple strategies that generate bounded solutions for the multiple‐choice multi‐dimensional knapsack problem: a guide for OR practitioners
Authors: Dellinger Anthony , Lu Yun , Song Myung Soon , Vasko Francis J. 
Published: April 2022

AbstractThe multiple‐choice multi‐dimensional knapsack problem (MMKP) is an NP‐hard generalization of the classic 0–1 knapsack problem. The MMKP has a variety of important industrial and business applications. Approximate solution approaches characteristically give no guarantees on solution quality. Exact solution approaches usually generate solutions that are guaranteed to be close to the optimum but typically take excessive computation times—one to several hours have been recorded in the literature. In this article, we use both simple single‐step and multiple step strategies to demonstrate how a commercial software package (Gurobi in this case) can easily be used to generate guaranteed tightly bounded solutions for 293 MMKP instances commonly tested in the literature. These four simple strategies that require no problem‐specific algorithms are shown to perform competitively with the five best published algorithms for the MMKP. Since no problem‐specific coding is required, these simple strategies are easy for operations research practitioners to use.
Development and psychometric testing of the safety climate instrument suitable for nurses handling chemotherapy drugs
Authors: Lin Ying‐Siou , Gau Bih‐Shya , Liang Jyh‐Chong , Chen Hai‐Chiao , Shih Fuh‐Yuan , Lin Yen‐Chun , Lou Meei‐Fang 
Published: April 2022

AbstractAimTo develop and test the psychometric properties of the Taiwanese safety climate instrument suitable for nurses handling chemotherapy drugs.DesignThis is an instrument development study.MethodAll four stages, including questionnaire design, expert consultation, cognitive testing and psychometric validation, were used in this study. The data were collected between August and December 2018. Nurses with experience in handling chemotherapy drugs (N = 484) at one medical centre and two regional hospitals in Taiwan completed this instrument. Data were randomly split into two groups: one group (N = 237) for exploratory factor analysis and the other (N = 247) for confirmatory factor analysis.ResultsThe instruments' items were based on qualitative research, and the content validity index levels exceeded the acceptable value. An exploratory factor analysis revealed 43 items remaining in six factors, which accounted for 74.4% of variance. The result of the confirmatory factor analysis verified the acceptability of a 43‐item model. The composite reliability values, Cronbach's alpha values, convergent validity and discriminant validity for each factor exceeded the acceptable value.ConclusionMost climate safety instruments used in the health care sector focus mainly on patient safety outcomes. Furthermore, there is no safety climate instrument for handling chemotherapy drugs, and there is a cultural difference. Through the development and validation process, we have developed a new instrument suitable for nurses handling chemotherapy drugs, which has good psychometric properties.ImpactThis instrument is valuable as its development was based on the concept of a safety climate for health care perceptions and qualitative survey findings. Hospital managers can use this instrument regularly to evaluate nurses' perceptions of the safety climate to determine the strengths and weaknesses of their workplace, thereby assisting organizational managers in proposing concrete actions.