bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iron Deficiency Impacts Diastolic Function, Aerobic Exercise Capacity, and Patient Phenotyping in Heart Failure With Preserved Ejection Fraction: A Subanalysis of the OptimEx-Clin Study
Authors: Gevaert Andreas B. , Mueller Stephan , Winzer Ephraim B. , Duvinage André , Van de Heyning Caroline M. , Pieske-Kraigher Elisabeth , Beckers Paul J. , Edelmann Frank , Wisløff Ulrik , Pieske Burkert , Adams Volker , Halle Martin , Van Craenenbroeck Emeline M. ,   for the OptimEx-Clin Study Group
Published: February 2022

AimsIron deficiency (ID) is linked to reduced aerobic exercise capacity and poor prognosis in patients with heart failure (HF) with reduced ejection fraction (HFrEF); however, data for HF with preserved ejection fraction (HFpEF) is scarce. We assessed the relationship between iron status and diastolic dysfunction as well as aerobic exercise capacity in HFpEF, and the contribution of iron status to patient phenotyping.Methods and ResultsAmong 180 patients with HFpEF (66% women; median age, 71 years) recruited for the Optimizing Exercise Training in Prevention and Treatment of Diastolic HF (OptimEx-Clin) trial, baseline iron status, including iron, ferritin, and transferrin saturation, was analyzed (n = 169) in addition to exercise capacity (peak oxygen uptake [peak V̇O2]) and diastolic function (E/e′). ID was present in 60% of patients and was more common in women. In multivariable linear regression models, we found that diastolic function and peak V̇O2 were independently related to iron parameters; however, these relationships were present only in patients with HFpEF and ID [E/e′ and iron: β−0.19 (95% confidence interval −0.32, −0.07), p = 0.003; E/e′ and transferrin saturation: β−0.16 (−0.28, −0.04), p = 0.011; peak V̇O2 and iron: β 3.76 (1.08, 6.44), p = 0.007; peak V̇O2 and transferrin saturation: β 3.58 (0.99, 6.16), p = 0.007]. Applying machine learning, patients were classified into three phenogroups. One phenogroup was predominantly characterized by the female sex and few HFpEF risk factors but a high prevalence of ID (86%, p &lt; 0.001 vs. other phenogroups). When excluding ID from the phenotyping analysis, results were negatively influenced.ConclusionIron parameters are independently associated with impaired diastolic function and low aerobic capacity in patients with HFpEF and ID. Patient phenotyping in HFpEF is influenced by including ID.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier NCT02078947.
Visceral Adiposity, Inflammation, and Testosterone Predict Skeletal Muscle Mitochondrial Mass and Activity in Chronic Spinal Cord Injury
Authors: Goldsmith Jacob A. , Lai Raymond E. , Garten Ryan S. , Chen Qun , Lesnefsky Edward J. , Perera Robert A. , Gorgey Ashraf S. 
Published: February 2022

BackgroundMitochondrial health is an important predictor of several health-related comorbidities including obesity, type 2 diabetes mellitus, and cardiovascular disease. In persons with spinal cord injury (SCI), mitochondrial health has been linked to several important body composition and metabolic parameters. However, the complex interplay of how mitochondrial health is affected has yet to be determined in this population.ObjectiveIn this study, we examined the contribution of visceral adiposity, inflammatory biomarkers, testosterone and circulating serum growth factors as predictors of mitochondrial health in persons with chronic SCI.ParticipantsThirty-three individuals with chronic SCI (n = 27 Males, n = 6 Females, age: 40 ± 13.26 years, level of injury: C4-L1, BMI: 23 ± 5.57) participated in this cross-sectional study.MethodsVisceral adipose tissue (VAT) was measured via magnetic resonance imaging (MRI). After an overnight fast, serum testosterone, inflammatory biomarkers [interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), c-reactive protein (CRP)], and anabolic growth factors [insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3)] were measured. Skeletal muscle biopsies were obtained from the vastus lateralis muscle to measure citrate synthase (CS) and Complex III activity. Regression analyses were used to examine predictors of mitochondrial mass and activity.ResultsCS activity was negatively associated with VAT (r2 = 0.360, p &lt; 0.001), CRP (r2 = 0.168, p = 0.047), and positively associated with testosterone (r2 = 0.145, p = 0.042). Complex III activity was negatively associated with VAT relative to total lean mass (VAT:TLM) (r2 = 0.169, p = 0.033), trended for CRP (r2 = 0.142, p = 0.069), and positively associated with testosterone (r2 = 0.224, p = 0.010). Multiple regression showed CS activity was significantly associated with VAT + CRP (r2 = 0.412, p = 0.008) and VAT + Testosterone (r2 = 0.433, p = 0.001). Complex III activity was significantly associated with VAT relative to total trunk cross-sectional area (CSA) + CRP (VAT:total trunk CSA + CRP; r2 = 0.286, p = 0.048) and VAT + Testosterone (r2 = 0.277, p = 0.024).ConclusionIncreased visceral adiposity and associated inflammatory signaling (CRP) along with reduced testosterone levels predict mitochondrial dysfunction following SCI. Specifically, lower VATCSA and higher testosterone levels or lower VATCSA and lower CRP levels positively predict mitochondrial mass and enzyme activity in persons with chronic SCI. Future research should investigate the efficacy of diet, exercise, and potentially testosterone replacement therapy on enhancing mitochondrial health in chronic SCI.Clinical Trial Registration[www.ClinicalTrials.gov], identifier: [NCT02660073].
Childhood Trauma in Patients With PAH—Prevalence, Impact on QoL, and Mental Health—A Preliminary Report
Authors: Park Da-Hee , Meltendorf Tanja , Kahl Kai G. , Kamp Jan C. , Richter Manuel J. , Gall Henning , Ghofrani Hossein A. , Hoeper Marius M. , Olsson Karen M. , Fuge Jan 
Published: February 2022

Background/ObjectiveChild maltreatment is associated with increased risk of psychological consequences, contributes to morbidity and has long lasting effects on mental health and quality of life. Child maltreatment has not been assessed in patients with pulmonary arterial hypertension (PAH). We examined the prevalence of child maltreatment and determined their impact on disease severity in patients with PAH.MethodsA cross-sectional observational multicenter study at two PH centers in Germany was conducted. Patients with a confirmed diagnosis of PAH were given a self-administered questionnaire. Child maltreatment using the Childhood Trauma Questionnaire (CTQ), quality of life (QoL), anxiety, depression, and lifestyle factors were assessed and enhanced by clinical parameters 6-min walk distance (6MWD), WHO functional class (WHO FC), and serum levels of N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP). Prevalence rates of child maltreatment were compared to the general population and impact of child maltreatment on disease severity was calculated by logistic regression analysis.ResultsTwo-hundred and seventeen patients, 71% female and a median age of 56 years were enrolled in this study. Patients with PAH had higher rates of emotional abuse and lower rates of physical neglect compared to the German population while rates of emotional neglect, physical abuse, and sexual abuse did not differ between patients and German population. Patients with any form of child maltreatment were more likely to be active smokers, had a worse QoL and more anxiety or depression. Moderate associations between child maltreatment, mental health, QoL, lifestyle factors and clinical parameters could be observed. Logistic regression analysis showed a significant impact of CTQ-total score on disease severity with an OR of 1.022 (95%-CI: 1.001–1.042, p = 0.035).ConclusionWe found a higher rate of child maltreatment in patients with PAH in comparison to the German population. Correlations suggest moderate associations between CTQ-scores and mental health as well as QoL. Child maltreatment had significant impact on disease severity. However, effects were moderate. We conclude that child maltreatment has effects on mental health and quality of life in patients with PAH and may have limited effect on disease severity.
Psychological Traits of Patients With Depression Comorbid With Chronic Pain: Are Complaint and Competitive Tendency Related to Pain?
Authors: Fujimoto Koji , Hosoi Masako , Katsuki Ryoko , Matsushima Toshio , Matsuo Keitaro , Nakao Tomohiro , Sudo Nobuyuki , Kato Takahiro A. 
Published: February 2022

BackgroundModern-Type Depression (MTD) is a category of depression that has been studied mainly in Japan; however, no study has attempted to determine its relation to chronic pain.AimTo determine possible associations between psychological traits related to MTD and the chronic pain of patients at psychiatric clinics.MethodTwo hundred and twenty-one first time patients who visited the psychiatric clinic at a Japanese university medical center or an associated clinic were enrolled. The Hamilton Depression Rating Scale was used to measure depressive symptoms. The 22-item Tarumi's Modern-Type Depression Trait Scale (TACS-22), Achievement Motive, and 20-item Toronto Alexithymia Scale were used to assess psychological traits related to depression and chronic pain. The clinical diagnosis of each patient was confirmed by use of the Structured Clinical Interview for DSM-IV Axis I Disorders, administered by experienced specialists. The medians of the psychological traits identified were compared between patients with or without chronic pain. Analysis was also done of patients with Major Depressive Disorder (MDD).ResultOf the 221 patients, 139 had chronic pain. Patients with chronic pain had more severe depressive symptoms, Alexithymia, and high scores for the complaint trait of MTD. Seventy-three of the 221 patients met the criteria for MDD (53 had chronic pain). Patients with MDD comorbid with chronic pain had a higher competitive achievement score, severe depression, and difficulty identifying feelings.ConclusionComplaint and competitive traits were shown to be related to chronic pain in psychiatric settings. Further study will allow us to design multidimensional approach for patients suffering from depression.
Depression, Anxiety and Sleep Alterations in Caregivers of Persons With Dementia After 1-Year of COVID-19 Pandemic
Authors: Bussè Cinzia , Barnini Teresa , Zucca Milena , Rainero Innocenzo , Mozzetta Stefano , Zangrossi Andrea , Cagnin Annachiara 
Published: February 2022

BackgroundSocial isolation due to COVID-19 pandemic has an important psychological impact particularly in persons with dementia and their informal caregivers.AimTo assess frequency and severity of long-term stress-related symptoms in caregivers of patients with dementia 1-year after the beginning of COVID-19 pandemic and to identify predictors of psychological outcomes.MethodsEighty-five caregivers were involved in a longitudinal study with 1-year follow-up during pandemic in Italy. At baseline in April 2020 a telephone interview assessed socio-demographic characteristics of caregivers and self-perception of distress symptoms. After 1 year, between March and April 2021, the same standardized interview was delivered to the caregivers' sample. In addition, scales assessing levels of depression and anxiety (DASS-21), sleep disturbances (PSQI) and coping strategies (COPE-NVI) were administered to the caregivers and to 50 age and sex-matched non-caregivers subjects. Linear regression analysis was performed to investigate the power of baseline variables to predict long-term psychological outcomes.ResultsAfter 1 year of pandemic frequency of caregivers' stress-related symptoms increased respect to baseline: depression (60 vs. 5, 9%; p &lt; 0.001), anxiety (45, 9 vs. 29, 4%; p = 0.035), irritability (49, 4 vs. 24, 7%; p &lt; 0.001), and anguish (31, 7 vs. 10, 6%; p &lt; 0.001). Frequency of severe depression was higher in caregivers than in non-caregivers (p = 0.002) although mean levels of depression were comparable in the two groups. Long-term higher depression was predicted by a model built on baseline information (r2 = 0.53, p &lt; 0.001) where being female (t = −3.61, p &lt; 0.001), having lower education (t = −2.15, p = 0.04), presence of feelings of overwhelm (t = 2.29, p = 0.02) and isolation (t = 2.12, p = 0.04) were significant predictors. Female sex was also predictive of anxiety (t = −2.7, p = 0.01) and poor sleep quality (t = −2.17, p = 0.03).DiscussionAt 1 year follow-up caregivers of patients with dementia reported higher prevalence of all stress-related symptoms respect to the acute phase of lockdown, particularly depression. Long-lasting stressful conditions may cause exhaustion of resilience factors and increased depression. Planning interventions should support caregivers to enable them to continue with their role during pandemic.
DIAGNÓSTICO DE LAS CONDICIONES DE SALUD DE LOS CARPINTEROS DEL QUINDÍO (COLOMBIA)
Authors: Gómez-Yepes Milena Elizabeth , Sánchez-López Juan Farid , Torres Paola , Sánchez Deisy , Camargo Lina María , Castañeda Rene Arturo , Fierro-Pioquinto Jaime , Cardona Angela María , Villamizar Rafael Humberto , Cremades Lazaro Vicente 
Published: February 2022

Se realizó un estudio descriptivo observacional de las condiciones de salud de los trabajadores de las áreas de lijado, cepillado y pinturas (trabajadores con mayor probabilidad de sufrir problemas o enfermedades respiratorias por exposición al polvo de madera). Teniendo en cuenta la similitud de tareas, utilización de materiales y equipos se tomó una muestra por conveniencia de 10 empresas más representativas del Quindío. Se encuestaron el 100% de los trabajadores de las áreas antes mencionadas. El 22.6% dieron positivo a problemas respiratorios; estos trabajadores fueron elegidos para la elaboración de las historias clínicas ocupacionales. Se detectó el uso de maderas duras y blandas en la elaboración del mueble, así como inmunizantes o plaguicidas, solventes orgánicos volátiles, resinas epóxicas sintéticas, pegamentos y pinturas para los acabados de la madera. Del total de los encuestados, 45% eran mujeres y 55 % hombres, siendo las mujeres cabeza de hogar. El promedio de edad fue de 31 años, el más joven de 19 y el mayor de 51 años. Con respecto a los hábitos, el 20% son fumadores y el 45% ingieren alcohol. El 45% practican deportes y el 100% negó padecer alguna enfermedad profesional. El 100% de los trabajadores se quejó de de sufrir de tos, ronquera, renitis, conjuntivitis y gripas frecuentes. Es notable la falta de estilos de vida saludables y de programas de vigilancia epidemiológica de las empresas, que, junto a las condiciones ambientales existentes en sus áreas de trabajo, generan un importante factor de riesgo para eventos crónicos de salud, como la enfermedad pulmonar obstructiva crónica (EPOC).
ANALISIS TATANIAGA KELAPA SAWIT (Elaeis guineensis Jacq.) (STUDI KASUS : KECAMATAN KUALUH SELATAN KABUPATEN LABUHAN BATU UTARA)
Authors: Sirait Maruli Tua 
Published: February 2022

Kelapa sawit merupakan komoditas unggulan di Kecamatan Kualuh Selatan Kabupaten Labuhanbatu Utara. Berdasarkan latar belakang, maka tujuan penelitian ini adalah menganalisis marjin dan farmer share atau kinerja indusri kelapa sawit. Pemilihan Kecamatan Kualuh Selatan sebagai lokasi penelitian dilakukan secara purposive (sengaja)dengan pertimbangan bahwa daerah tersebut sebagai daerah sentra produksi kelapa sawit.Lembaga yang terlibat dalam pemasaran komoditas kelapa sawit di Kecamatan Kualuh Selatan adalah agen kecil, agen besar dan pabrik. Masing-masing lembaga tersebut menjalankan fungsi pemasaran yang terdiri dari tiga fungsi pokok yaitu pertukaran, fisik dan fasilitas. Pola saluran pemasaran yang terbentuk untuk komoditas kelapa sawit ada tiga yaitu: 1) petani–pabrik; 2) petani–agen besar–pabrik 3) petani–agen kecil–agen besar–pabrik. Kinerja pasar kelapa sawit di Kecamatan Kualuh Selatan menunjukkan bahwah 3 saluran pemasaran dengan total marjin yang berbeda beda, semakin banyak lembaga pemasaran yang terlibat maka marjin pemasaran semakin tinggi, hal ini farmer share semakin rendah. Saluran yang paling efisien adalah saluran pemasaran 1 (petani–pabrik).
PENGARUH PENDAPATAN PER BULAN, HARGA, JUMLAH TANGGUNGAN KELUARGA, DAN SELERA TERHADAP KEPUTUSAN MEMBELI MINYAK GORENG CURAH DI PASAR TRADISIONAL
Authors: Purba Mohd Nawi 
Published: February 2022

Tujuan penelitian ini adalah untuk menganalisis pendapatan per bulan, harga, jumlah tanggungan keluarga, dan selera konsumen minyak goreng curah di lokasi penelitian. Menganalisis pengambilan keputusan konsumen dalam membeli minyak goreng curah, dan untuk mengetahui faktor-faktor yang berpengaruh terhadap keputusan konsumen dalam membeli minyak goreng curah. Pengambilan sampel dilakukan dengan mengggunakan teknik “proportional Random Sampling” dengan sampel sebanyak 100 responden. Metode analisis yang digunakan adalah metode analisis regresi berganda. Pengolahan data dibantu dengan statistical package social science (SPSS) versi 23.
Penelitian ini dilakukan pada bulan Juli 2018. Hasil penelitian dapat disimpulkan bahwa (1) Pendapatan per bulan berpengaruh signifikan dengan keputusan membeli minyak goreng curah di pasar tradisional sei sikambing medan; (2) Harga berpengaruh signifikan dengan keputusan membeli minyak goreng curah di pasar tradisional sei sikambing medan; (3) Jumlah tanggungan keluarga berpengaruh signifikan dengan keputusan membeli minyak goreng curah di pasar sei sikambing medan; (4) Selera tidak berpengaruh signifikan dengan keputusan membeli minyak goreng curah di pasar tradisional sei sikambing medan; (5) Pendapatan per bulan, harga, jumlah tanggungan keluarga, dan selera berpengaruh signifikan dengan keputusan membeli minyak goreng curah di pasar tradisional sei sikambing medan.
Training for parents on forming the skills of effective interaction with children as a means of prevention of riskable behavior of children and adolescents
Authors: Yarova L. D. 
Published: February 2022

Researchers at the World Health Organization are drawing attention to the long-term effects of risky behavior on adolescent children, as 35% of the global burden of illness originates in adolescence. According to the WHO definition, violence can be a cause of infectious and non-communicable diseases, psychological trauma, and also a risk behavior for children and adolescents.
Purpose of the study. The effective means identifying of preventing risky behavior in children and adolescents.
Materials and methods. One of the factors affecting the formation of appropriate «risk behaviors» in children and adolescents can be considered as various forms of violence. In order to find out the appropriate situation in Zaporizhzhya we conducted a study aimed at determining the degree of prevalence of physical, psychological and sexual abuse among adolescents of vocational establishments of the city. 283 vocational school students, whose average age years from 15 to 17.
The questionnaire included behavioral and social risk factors in the family, interviews with adolescents about physical, psychological, and sexual abuse against them, if so, by whom: parents, teachers, classmates, acquaintances, and acquaintances.
In accordance with the set tasks and to achieve the goal of the research, we used a set of general scientific and special methods interrelated and consistently applied during the research: system analysis, biblio-semantic, statistical, correlation.
Results and discussion. When asked whether the facts of physical violence with punishment from 283 respondents confirmed the facts of physical violence with punishment against them – 78 persons, or 27,5% of the total number of respondents. Among the possible abusers (parents, teachers, classmates, acquaintances, and non-abusers) mentioned in the questionnaire, parents rank first in the number of cases of physical violence and punishment.
In cases where child abuse was recorded or observed, family members were prevented, which included targeted work with specific groups of adults and children. The purpose of the relevant work is to develop humane treatment of adults for children, life skills and skills of adults and children, clarify the nature and responsibility of child abuse through training.
Conclusions. An effective tool for preventing risky behavior of children and adolescents can be considered as training for parents to develop the skills of constructive interaction with children.
Improving the Surgical Stage of Complex Rehabilitation of Patients with Laryngeal Cancer
Authors: Федорова Е.Б. , Дайхес Н.А. , Виноградов В.В. , Решульский С.С. , Хабазова А.М. 
Published: February 2022

Цель. Улучшение результатов заживления раны после ларингэктомии у пациентов с диагнозом: рак гортани IVа-стадии (T4аN0M0). Материалы и методы. Проведен анализ результатов хирургического лечения у 30 пациентов сдиагнозом: рак гортани IVа-стадии (T4aN0M0). Пациенты распределены на 2 группы в зависимости от техники ушивания глотки. Результаты. У четырех пациентов из второй (контрольной) группы отмечалось заживление послеоперационной раны вторичным натяжением с формированием глоточного свища. Заключение. Разработанный способ закрытия дефекта глотки после ларингэктомии показал высокую эффективность и позволил уменьшить количество местных послеоперационных осложнений.
Purpose. Improvement of wound healing results after laryngectomy in patients diagnosed with the stage IV laryngeal cancer (T4aN0M0). Materials and methods. The results of surgical treatment of 30 patients diagnosed with the stage IV laryngeal cancer (T4aN0M0 were analyzed). The patients were divided into 2 groups depending on the technique of suturing the pharynx. Results. In patients from the second (control group) group, the postoperative wound was healed by secondary tension with the formation of a pharyngeal fistula. Conclusion. The developed method of closing the pharyngeal defect after laryngectomy showed high efficiency and let to reduce the number of local postoperative complications.
Spontaneous Intracranial Hypotension (Clinical Observations and Review of the Literature)
Authors: Лихачев С.А. , Астапенко А.В. , Терехов В.С. , Корбут Т.В. , Степанова Е.С. 
Published: February 2022

Спонтанная внутричерепная гипотензия (спонтанная ликворная гипотензия) - это редкий патологический синдром, возникающий в результате снижения давления спинномозговой жидкости ниже 50 мм вод. ст. Характерным клиническим признаком является позиционно зависимая головная боль, возникающая в течение 15-20 минут после вертикализации пациента. Особенностью этой боли является то, что она значительно уменьшается или вовсе проходит вгоризонтальном положении. Основной метод диагностики спонтанной внутричерепной гипотензии - магнитно-резонансная томография. В частности, миелография в настоящее время является самым достоверным методом для определения местоположения дефекта твердой мозговой оболочки и степени утечки ликвора. В статье приведены данные об эпидемиологии, патофизиологии, клинической картине, диагностике и методах лечения спонтанной ликворной гипотензии. Представлены собственные клинические наблюдения трех пациентов с синдромом спонтанной внутричерепной гипотензии.
Spontaneous intracranial hypotension (spontaneous cerebrospinal fluid hypotension) is a rare pathological syndrome resulting from the decrease of the pressure of cerebrospinal fluid in the dural sac below 50 mm water column. A typical clinical sign is a positional headache that occurs within 15-20 minutes after the patient is upright. A feature of this pain is that it is significantly reduced or completely disappears in a horizontal position. The main method for diagnosing spontaneous intracranial hypotension is magnetic resonance imaging. In particular, myelography is currently the most reliable method for determining the location of the dura mater defect and the extent of CSF leakage. The article provides data on epidemiology, pathophysiology, clinical presentation, diagnosis, and treatment methods in spontaneous cerebrospinal fluid hypotension. We present our own clinical observations of three patients with spontaneous intracranial hypotension syndrome.