bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of Treatment of Patients with Concomitant Aortic Lesions and Coronary Heart Disease
Authors: Zhekov Ihor I. , Kravchenko Vitalii I. , Sarhosh Oleh I. , Larionova Olena B. , Rudenko Anatoliy V. 
Published: March 2022

The aim. To determine the degree of increased operative risk in the group of patients with a combination of aortic aneurysms and coronary artery disease compared with those with isolated aortic aneurysms.
Materials and methods. In the period from January 1, 2010 to October 1, 2021 at the National Amosov Institute of Cardiovascular Surgery, 820 patients with aortic aneurysm, including 172 (20.9%) patients with concomitant aortic and coronary artery disease, underwent surgical treatment. Diagnosis was based on standard examination methods such as electrocardiography, transthoracic echocardiography, coronary angiography, and computed tomography without coronary angiography in cases of aortic dissection. In patients with aortic dissection and coronary artery disease, the extent of the lesion was examined mainly by CT diagnosis and Coronary Artery Disease Reporting and Data System (CAD-RADS) scale due to contraindications to coronary angiography.
Results.Thetotalnumberofcomplicationswas26(15.1%)cases.Cerebrovasculardisorderswereobservedin4(2.3%) cases, 3 of which regressed in the postoperative period; in all 4 (2.3%) cases there was a history of acute cerebrovascular disorders. Spinal cord ischemia was observed in 2 (1.2%) cases. Multiple organ failure occurred in the postoperative period in 6 (3.5%) patients, renal failure in 4 (2.3%) patients. Respiratory failure was found in 3 (1.7%) patients. Septic shock occurred in 1 (0.6%) patient. Increased exudation was present in 6 (3.5%) cases requiring rethoracotomy. There were 7 (4.0%) in-hospital deaths, 3 (9.3%) in the acute dissection group and 4 (2.9%) in the aortic aneurysm group without stratification. The distribution of patients by lethal complications was as follows: 1 (14.3%) patient had acute cerebrovascular accident, 1 (14.3%) had septic shock and 1 (14.3%) had acute renal failure. In more than 50% of cases, the cause of death was multiple organ failure (4 [57%] patients).
Conclusions. Concomitant lesions of arteries with aortic aneurysms are associated with higher rates of postoperative complications and mortality. In the group of patients with aortic dissection combined with coronary artery disease, there was longer duration of surgery, duration of artificial circulation and aortic compression due to the high initial severity of condition in such patients and greater complexity and volume of surgery. Hospital mortality in the group of aortic aneurysms combined with coronary artery lesions was almost 3 times higher than that in the group of isolated aortic aneurysms (4% and 1.5%, respectively).
Urgensi Membangun Iklim Belajar dalam Membentuk Karakter Peserta Didik
Authors: Windayana Husen , Annisa Annisa , Sudirman Putri Rizqi Aura Tanzil , Berlian Roja Khalda 
Published: March 2022

Pendidikan karakter merupakan sarana dan prasarana yang harus dimiliki oleh siswa sebagai pendidikan dasar sebelum memasuki kehidupan yang sebenarnya. Tujuan dari penelitian ini adalah menganalisis pengaruh iklim belajar dalam membentuk karakter pada peserta didik. Metode penelitian yang digunakan adalah metode kualitatif melalui penelitian studi pustaka. Hasil penelitian menunjukkan bahwa iklim belajar akan sangat mempengaruhi siswa dalam membentuk karakter mereka, hal ini karena dalam proses pembelajaran siswa membentuk pengalaman dan pengetahuan, sehingga iklim atau situasi belajar juga mempengaruhi proses memperoleh pengalaman dan pengetahuan yang sangat bermanfaat bagi pengembangan karakter siswa dilingkungan masyarakat. Pendidikan karakter melalui iklim belajar ini dapat diimplementasikan melalui beragam cara salah satunya seperti dijadikan mata pelajaran sendiri, terintegrasi dengan mata pelajaran lain, dan gabungan keduanya. Kemudian sebagai guru, terdapat beberapa cara agar dapat terbentuk iklim belajar yang kondusif, salah satunya ialah dengan pemberian tugas yang dapat membentuk kepribadian mandiri siswa, membuat aturan kelas bersama, dan bekerja sama membangun kelas yang nyaman dengan membuat barang kreatif dari benda-benda yang ada disekitar untuk membentuk kreativitas peserta didik. Sehingga dapat menghasilkan tujuan yang ingin dicapai yaitu membentuk iklim belajar yang efisien dan efektif khususnya di lingkungan sekolah yang membantu proses Pendidikan karakter dalam membentuk karakter pada peserta didik dapat terlaksanakan dengan baik.
Application of Seed Mucilage Extracted from Lallemantia royleana as a Suspending Agent
Authors: A.Abdulrasool Alaa , A.Naseer Abdulmuttalib , A.Rahi Firas 
Published: March 2022

The mucilage from the seeds of Lallemantia royleana family Labiatae was extracted and subjected to preformulation study for evaluation of its suitability for use as suspending agent. Furosemide suspensions were prepared using (1.5% w/v) of the extracted Lallemantia royleana mucilage, (1.5% w/v) chitosan and (0.35% w/v) xanthan gum. The mucilage was white in color and the average yield of dried mucilage obtained from L.royleana nutlets was 14 % w/w of the seeds used. It is sparingly soluble in water but swells in contact with it, giving a highly viscous solution. It is slightly acidic to neutral. It was found that the extracted natural mucilage of Lallemantia royleana exhibited a higher viscosity profile and it exhibited better mucoadhesive property in comparison to chitosan, Carbopol 934 and hydroxypropyl - methylcellulose. The result showed that the suspension of furosemide prepared with 1.5 % w/v of the extracted mucilage was found to be ideal and comparable with the other two preparations of xanthan gum 0.35% w/v and chitosan 1.5% w/v. The study revealed that the mucilage of Lallemantia royleana has good properties to be used as a suspending agent and the performance is comparable with that of chitosan and xanthan gum since it is of natural origin, non-toxic, and of good biocompatibility.
Key words: mucilage; polymer; excipient; drug delivery; suspension; Lallemantia royleana.
MODELLING OF MAGNESITE FLOTATIONS WITH TWO DIFFERENT COLLECTORS: BIOCOLLECTOR AND OLEATE
Authors: ÖZ AKSOY Derya , ÖZDEMİR Serhat , KOCA Sabiha , ÇAKMAK Hakan , AYTAR ÇELİK Pınar , ÇABUK Doç. Dr. Ahmet , KOCA Hüseyin 
Published: March 2022

As environmental concerns grow, flotation researches, particularly for the recovery of fine-grained ores, encourage "bioflotation" studies, in which biological origin alternatives are used instead of traditional flotation reactives. While bioflotation applications starting from the pyrite mineral have spread to many carbonate and oxide minerals over time, and biomaterials used as a bioreagent have diversified from the microorganism itself to its metabolites and even cell components.
In this article, the use of surfactin derived from Bacillus subtilis as a bio-collector in the flotation of magnesite was investigated. The results of bioflotation studies were compared to those of oleate, traditional magnesite collector. Moreover, process models were created with statistical design methods, and the verification results of the optimization studies using model datas showed that these models were statistically strong.
The Androids of Hephaestus: Between Human and Machine in the <em>Iliad</em>
Authors: Silverman Kenneth 
Published: March 2022

The description of Hephaestus’ workshop in Iliad 18 presents several kinds of fanciful automata. Contrary to several previous treatments of this topic, this paper argues that it is not anachronistic to think of these figures as “robots”—i.e., as having some kind of inner-workings, even though Homer does not explicitly say what they are. This discussion helps to situate the Homeric poems within the pre-history of Greek natural philosophy.
PENGARUH PEMAHAMAN KODE ETIK PROFESI AKUNTAN, KECERDASAN INTELEKTUAL, KECERDASAN EMOSIONAL, KECERDASAN SPIRITUAL DAN LOCUS OF CONTROL TERHADAP PERILAKU ETIS MAHASISWA AKUNTANSI
Authors: Riyana Ririn , Mutmainah Kurniawati , Maulidi Rizky 
Published: March 2022

Penelitian ini bertujuan untuk menganalisis pengaruh pemahaman kode etik profesi akuntan, kecerdasan intelektual, kecerdasan emosional, kecerdasan emosional, dan locus of control terhadap perilaku etis mahasiswa akuntansi.
Populasi dalam penelitian ini adalah mahasiswa prodi akuntansi fakultas ekonomi dan bisnis Universitas Sains Al-Qur’an sebanyak 382 mahasiswa.
Sampel dalam penelitian ini adalah 80 mahasiswa akuntansi yang masih aktif yang didapat melalui teknik model slovin dan menggunakan teknik analisis regresi linier berganda. Hasil menunjukkan bahwa pemahaman kode etik profesi akuntan, IQ, EQ, SQ dan LOC berpengaruh terhadap perilaku etis mahasiswa akuntansi.
Gaya Kepemimpinan Pengurus Organisasi IPMAKA (Ikatan Pelajar Mahasiswa Kandis) di Kecamatan Kandis Kabupaten Siak
Authors: Rahayu Nurmai , Ayub Daeng , Sumardi Sumardi 
Published: March 2022

Studi ini bertujuan untuk menjelaskan tentang leadership style pengurus organisasi IPMAKA (Ikatan Pelajar Mahasiswa Kandis) di Kecamatan Kandis Kabupaten Siak, yang meliputi: gaya kepemimpinan Pengurus Organisasi Ikatan Pelajar Mahasiswa Kandis di Kecamatan Kandis Kabupaten Siak dan daya tarik penyelesaian masalah kepemimpinan organisasi IPMAKA. Penelitian ini memiliki 4 indikator yaitu: (1)bentuk mempengaruhi Demokratis, (2)bentuk mepengaruhi Otokratis, (3)bentuk mempengaruhi paternalistik, (4)bentuk mempengaruhi Laissez faire. Dalam studi yang dilakukan ini, penulis menggunakan cara kualitatif bersama strategi deskriptif diterapkan guna memiliki situasi serta keadaan yang memang nyata. Studi ini ingin memiliki suatu pencapaian dalam bentuk pengetahuan yang dianilisis melalui bentuk mempengaruhi pemimpin Pengurus di Organisasi IPMAKA (Ikatan Pelajar Mahasiswa Kandis) yang terletak di Kecamatan Kandis, Kabupaten Siak. Hasil penelitian ini menunjukkan bahwa sudah berjalan cukup baik, namun sebagian pengurus organisasi IPMAKA ada yang masih belum memahami fungsi dan tugasnya dalam menjalankan organisasi.

This study addreses the leadership style of the IPMAKA (Kandis Student Association) organizational management in Kandis District, Siak Regency, including: the leadership style of the Kandis Student Association Management Organization in Kandis District, Siak Regency, and solving problems in the leadership of the IPMAKA organization. That it has been explained in the field results that there is a history of the formation of IPMAKA to the implementation of new management from the old and new periods at IPMAKA, there is an attraction for the authors to examine this study by seeing that there is an unusual problem solving in an organization. This study has 4 indicators, namely: (1) the form of influencing the Democratic, (2) the form of influencing the Autocratic, (3) the form of influencing the paternalistic, (4) the form of influencing Laissez faire. In this study, the author uses a qualitative method along with a descriptive strategy to apply real situations and circumstances. This study wants to have an achievement in the form of knowledge which is analyzed through influencing the leaders of the Management at the IPMAKA Organization (Kandis Student Association) located in Kandis District, Siak Regency.
PENERAPAN MODEL PEMBELAJARAN INKUIRI TERBIMBING UNTUK MENINGKATKAN HASIL BELAJAR IPA PADA SISWA KELAS I SD NEGERI 2 GLANGGANG
Authors: Wibowo Andi , Suryani Sri 
Published: March 2022

Penelitian ini bertujuan untuk meningkatkan hasil belajar IPA siswa kelas I SD Negeri 2 Glanggang dengan menggunakan model pembelajaran inkuiri terbimbing. Model pembelajaran inkuiri terbimbing adalah model pembelajaran terdiri dari beberapa tahapan yaitu, orientasi masalah, merumuskan masalah, membuat hipotesis, menguji hipotesis, mengumpulkan dan menganalisis data serta membuat kesimpulan. Jenis penelitian ini adalah penelitian tindakan kelas (PTK) dengan model Kemmis & Mc Taggart. Penelitian ini dalam perencanaanya menggunakan sistem spiral refleksi diri yang dimulai dengan rencana, tindakan, pengamatan, refleksi, dan perencanaan kembali. Penelitian tindakan kelas ini terdiri dari dua siklus, dimana setiap siklus terdiri atas tahapan perencanaan, pelaksanaan, observasi dan refleksi. Subjek penelitian ini adalah siswa kelas I SD Negeri Glanggang Kecamatan Pakisaji Kabupaten Malang pada tahun pelajaran 2017/2018, dengan jumlah 50 siswa. Materi IPA yang digunakan dalam penelitian ini adalah materi IPA semester 2 yaitu gerak benda. Hasil dari penelitian ini adalah hasil belajar siswa meningkat. Hasil belajar pada kegiatan pra tindakan diperoleh nilai rata-rata siswa 62 dengan ketuntasan belajar 58%. Hasil belajar pada siklus I nilai rata-rata siswa 74,42 dengan ketuntasan belajar 72%. Hasil belajar pada iklus II nilai rata-rata siswa meningkat menjadi 80,82 dengan ketuntasan 82%. Berdasarkan hasil penelitian tersebut dapat disimpulkan bahwa penerapan model inkuri terbimbing dapat meningkatkan hasil belajar IPA pada siswa kelas I SD Negeri 2 Glanggang Kecamatan Pakisaji Kabupaten Malang.
Pulmonary Visceral Pleura Biomaterial: Elastin- and Collagen-Based Extracellular Matrix
Authors: Lu Xiao , Han Ling , Kassab Ghassan S. 
Published: March 2022

Objective: The goal of the study is to determine the structural characteristics, mechanical properties, cytotoxicity, and biocompatibility of the pulmonary visceral pleura (PVP).Background: Collagen and elastin are the major components of the extracellular matrix. The PVP has an abundance of elastin and collagen that can serve as a potential biomaterial for clinical repair and reconstructions.Methods: The PVP was processed from swine and bovine lungs. Chemical analyses were used to determine collagen and elastin contents in the PVPs. Immunofluorescence microscopy was used to analyze the structure of the PVP. The stress–strain relationships and stress relaxation were determined by using the planar uniaxial test. The cytotoxicity of the PVP was tested in cultured cells. In in vivo evaluations, the PVP was implanted in the sciatic nerve and skin of rats.Results: Collagen and elastin contents are abundant in the PVP with larger proportions of elastin than in the bovine pericardium and porcine small intestinal submucosa. A microstructural analysis revealed that the elastin fibers were distributed throughout the PVP and the collagen was distributed mainly in the mesothelial basal lamina. The incremental moduli in stress–strain curves and relaxation moduli in the Maxwell–Wiechert model of PVP were approximately one-tenth of the bovine pericardium and small intestinal submucosa. The minimal cytotoxicity of the PVP was demonstrated. The axons proliferated in the PVP conduit guidance from proximal to distal sciatic nerves of rats. The neo-skin regenerated under the PVP skin substitute within 4 weeks.Conclusions: The PVP is composed of abundant collagen and elastin. The structural characteristics and mechanical compliance of the PVP render a suitable biological material for repair/reconstruction.
The Shape of Corneal Deformation Alters Air Puff–Induced Loading
Authors: Yousefi Atieh , Roberts Cynthia J. , Reilly Matthew A. 
Published: March 2022

Purpose: To determine the dynamic modification of the load exerted on the eye during air-puff testing by accounting for the deformation of the cornea.Methods: The effect of corneal load alteration with surface shape (CLASS) was characterized as an additional component of the load produced during the concave phase where the fluid outflow tangential to the corneal surface creates backward pressure. Concave phase duration (tCD), maximum CLASS value (CLASSmax), and the area under CLASS-time curve (CLASSint) are calculated for 26 keratoconic (KCN), 102 normal (NRL), and 29 ocular hypertensive (OHT) subjects. Tukey’s HSD tests were performed to compare the three subject groups. A p-value less than 0.05 was considered statistically significant.Results: Accounting for CLASS increased the load by 34.6% ± 7.7% at maximum concavity; these differences were greater in KCN subjects (p &lt; 0.0001) and lower in OHT subjects (p = 0.0028) than in NRL subjects. tCD and CLASSint were significantly longer and larger, respectively, for KCN subjects than those in the NRL and OHT groups (p &lt; 0.0001).Conclusion: Load characterization is an essential step in assessing the cornea’s biomechanical response to air-puff–induced deformation. The dynamic changes in the corneal surface shape significantly alter the load experienced by the corneal apex. This implies a subject-specific loading dynamic even if the air puff itself is identical. This is important when comparing the same eye after a surgical procedure or topical medication that alters corneal properties. Stiffer corneas are least sensitive to a change in load, while more compliant corneas show higher sensitivity.
Microfluidic Chip for the Electrochemical Detection of MicroRNAs: Methylene Blue Increasing the Specificity of the Biosensor
Authors: Poujouly Claire , Le Gall Jérémy , Freisa Martina , Kechkeche Djamila , Bouville David , Khemir Jihed , Gonzalez-Losada Pedro , Gamby Jean 
Published: March 2022

MicroRNAs (miRNAs) are biomarkers involved in biological processes that are released by cells and found in biological fluids such as blood. The development of nucleic acid-based biosensors has significantly increased in the past 10 years because the detection of such nucleic acids can easily be applied in the field of early diagnosis. These biosensors need to be sensitive, specific, and fast in order to be effective. This work introduces a newly-built electrochemical biosensor that enables a fast detection in 30 min and, as a result of its integration in microfluidics, presents a limit of detection as low as 1 aM. The litterature concerning the specificity of electrochemical biosensors includes several studies that report one base-mismatch, with the base-mismatch located in the middle of the strand. We report an electrochemical nucleic acid biosensor integrated into a microfluidic chip, allowing for a one-base-mismatch specificity independently from the location of the mismatch in the strand. This specificity was improved using a solution of methylene blue, making it possible to discriminate a partial hybridization from a complete and complementary hybridization.
Discovery of 2-(4-Acrylamidophenyl)-Quinoline-4-Carboxylic Acid Derivatives as Potent SIRT3 Inhibitors
Authors: Hui Qian , Li Xueming , Fan Wenli , Gao Congying , Zhang Lin , Qin Hongyu , Wei Liuya , Zhang Lei 
Published: March 2022

In discovery of novel SIRT3 inhibitors for the treatment of cancer, a series of 2-(4-acrylamidophenyl)-quinoline-4-carboxylic acid derivatives were designed and synthesized. Among the derived compounds, molecule P6 exhibited SIRT3 inhibitory selectivity with IC50 value of 7.2 µM over SIRT1 (32.6 µM) and SIRT2 (33.5 µM). molecular docking analysis revealed a specific binding pattern of P6 in the active site of SIRT3 compared with the bindings in the active site of SIRT1 and SIRT2. In the antiproliferative and colony forming assay, molecule P6 showed potent inhibitory activity against a group of MLLr leukemic cell lines. Further analysis revealed that induction of G0/G1 phase cell cycle arrest and cell differentiation, but not apoptosis, makes contributions to the anticancer effects of P6. Collectively, a potent SIRT3 inhibitor (P6) was discovered as a lead compound for the leukemic differentiation therapy.
Lacticaseibacillus rhamnosus GG Counteracts Rotavirus-Induced Ion Secretion and Enterocyte Damage by Inhibiting Oxidative Stress and Apoptosis Through Specific Effects of Living and Postbiotic Preparations
Authors: Buccigrossi Vittoria , Poeta Marco , Cioffi Valentina , Terranova Sara , Nunziata Francesco , Lo Vecchio Andrea , Guarino Alfredo 
Published: March 2022

BackgroundAdministration of Lacticaseibacillus rhamnosus GG (LGG) to children with gastroenteritis is recommended by universal guidelines. Rotavirus (RV) causes diarrhea through combined cytotoxic and enterotoxic effects. Aim of this study was to evaluate the mechanisms of efficacy of LGG in an in-vitro model of RV diarrhea in its viable form (LGG) and conditioned medium (mLGG).MethodsIon secretion corresponding to the NSP4 enterotoxic effect, was evaluated by short circuit current (Isc) and the cytotoxic effect by transepithelial electrical resistance (TEER) in Ussing chambers, upon exposure to RV in Caco-2 enterocyte monolayers treated or not with living probiotic or its culture supernatant. Mechanisms of enterotoxic and cytotoxic damage were evaluated including oxidative stress measured by reactive oxygen species, apoptosis evaluated by DAPI and nuclear staining, NFkβ immunofluorescence.ResultsRV induced Isc increase and TEER decrease, respectively indicating ion secretion and epithelial damage, the two established pathways of diarrhea. Both probiotic preparations reduced both diarrheal effects, but their potency was different. Live LGG was equally effective on both enterotoxic and cytotoxic effect whereas mLGG was highly effective on ion secretion and showed minimal protective effects on cytoskeleton, apoptosis and NFkβ.ConclusionsLGG counteracts RV-induced diarrhea by inhibiting both cytotoxic and enterotoxic pathogenic mechanisms. Namely, LGG inhibits chloride secretion by specific moieties secreted in the medium with a direct pharmacologic-like action. This is considered a postbiotic effect. Subsequently, live bacteria exert a probiotic effect protecting the enterocyte structure.
Cost Utility Analysis of Multidisciplinary Postacute Care for Stroke: A Prospective Six-Hospital Cohort Study
Authors: Chen Yu-Ching , Yeh Yu-Jo , Wang Chung-Yuan , Lin Hsiu-Fen , Lin Ching-Huang , Hsien Hong-Hsi , Hung Kuo-Wei , Wang Jung-Der , Shi Hon-Yi 
Published: March 2022

BackgroundFew studies have compared the optimal duration and intensity of organized multidisciplinary neurological/rehabilitative care delivered in a regional/district hospital with the standard rehabilitative care delivered in the general neurology/rehabilitation ward of a medical center. This study measured functional outcomes and conducted cost-utility analysis of an organized multidisciplinary postacute care (PAC) project in secondary care compared with standard rehabilitative care delivered in tertiary care.MethodsThis prospective cohort study enrolled 1,476 patients who had a stroke between March 2014 and March 2018 and had a modified Rankin scale score of 2–4. After exact matching for age ± 1 year, sex, year of stroke diagnosis, nasogastric tube, and Foley catheter and propensity score matching for the other covariates, we obtained 120 patients receiving PAC (the PAC group) from four regional/district hospitals and 120 patients not receiving PAC (the non-PAC group) from two medical centers.ResultsAt baseline, the non-PAC group showed significantly better functional outcomes than the PAC group, including EuroQol-5 dimensions (EQ-5D), Mini-Mental State Examination (MMSE) and Barthel index (BI). During weeks 7–12 of rehabilitation, improvements in all functional outcomes were significantly larger in the PAC group (P &lt; 0.001) except for Functional Oral Intake Scale (FOIS). Cost-utility analysis revealed that the PAC group had a significantly lower mean (± standard deviation) of direct medical costs (US$3,480 ± $1,758 vs. US$3,785 ± $3,840, P &lt; 0.001) and a significantly higher average gain of quality-adjusted life years (0.1993 vs. 0.1233, P &lt; 0.001). The PAC project was an economically “dominant” strategy.ConclusionsThe PAC project saved costs and significantly improved the functional outcomes of patients with stroke with slight to moderately severe disabilities. Randomized control trials are required to corroborate these results.