bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered higher-order coupling between brain structure and function with embedded vector representations of connectomes in schizophrenia
Authors: Wang Bin , Guo Min , Pan Tingting , Li Zhifeng , Li Ying , Xiang Jie , Cui Xiaohong , Niu Yan , Yang Jiajia , Wu Jinglong , Liu Miaomiao , Li Dandan 
Published: December 2022

Abstract
It has been shown that the functional dependency of the brain exists in both direct and indirect regional relationships. Therefore, it is necessary to map higher-order coupling in brain structure and function to understand brain dynamic. However, how to quantify connections between not directly regions remains unknown to schizophrenia. The word2vec is a common algorithm through create embeddings of words to solve these problems. We apply the node2vec embedding representation to characterize features on each node, their pairwise relationship can give rise to correspondence relationships between brain regions. Then we adopt pearson correlation to quantify the higher-order coupling between structure and function in normal controls and schizophrenia. In addition, we construct direct and indirect connections to quantify the coupling between their respective functional connections. The results showed that higher-order coupling is significantly higher in schizophrenia. Importantly, the anomalous cause of coupling mainly focus on indirect structural connections. The indirect structural connections play an essential role in functional connectivity–structural connectivity (SC–FC) coupling. The similarity between embedded representations capture more subtle network underlying information, our research provides new perspectives for understanding SC–FC coupling. A strong indication that the structural backbone of the brain has an intimate influence on the resting-state functional.
Three-year follow-up of aortic arch endovascular stent grafting with the Nexus device: results from a prospective multicentre study
Authors: D’Onofrio Augusto , Lachat Mario , Mangialardi Nicola , Antonello Michele , Schelzig Hubert , Chaykovska Lyubov , Hill Andrew , Holden Andrew , Lindsay Thomas , Ten Tan Kong , Orrico Matteo , Ronchey Sonia , Greener Gabby Elbaz , Hayes Paul , Lorenzoni Giulia , Gerosa Gino , Planer David 
Published: December 2022

Abstract

OBJECTIVES
Endovascular aortic arch stent grafting with branched devices has shown initial promising results. The aim of this prospective, multicentre study was to evaluate 3-year outcomes of aortic arch stent grafting with NEXUS® Aortic Arch Stent Graft System (Nexus), a single-branch, bi-modular, off-the-shelf aortic arch stent graft system in high-risk patients.

METHODS
Patients treated with Nexus, either under the feasibility clinical study or as compassionate use procedures in 5 centres, were included in this study. The primary end point was overall survival. The secondary end points included the incidence of procedure-related unplanned intervention, stroke, paraplegia and endoleak. Clinical and radiologic follow-up was performed at each study site at 30 days, 6 months and on a yearly basis thereafter up to 3 years postoperatively.

RESULTS
We analysed data from a total of 28 patients. The overall median follow-up was 1132 (interquartile range: 809–1537). There were no device or procedure-related deaths between 1 and 3 years. Overall survival at 1 and 3 years was 89% and 71%, respectively. The cumulative incidence of unplanned reintervention at 1 and 3 years was 11% and 29%, respectively. There were no reports of stroke, paraplegia, aneurysm rupture, myocardial infarction or new aortic valve insufficiency. In this study’s 1–3 year follow-up period, 1 type Ib (4%), 1 type II (4%) and 2 type III (8%; between Nexus’ distal end and Thoracic endovascular aortic repair (TEVAR) extensions) endoleak were detected.

CONCLUSIONS
Endovascular aortic arch exclusion with the single-branch, off-the-shelf Nexus system provides promising clinical and radiologic results at 3-year follow-up in a high-risk patient cohort.
Germination and Micropropagation ofCrataegus monogynaJacq. Seeds by Tissue Culture Method
Authors: Dinçer Deryanur , Bekiryazıcı Fatih , Dündar Havva , Ögçe Hüseyin 
Published: December 2022

AbstractThe propagation of Crataegus monogyna Jacq. using seeds is important for the creation of new cultivars, but it can be fraught with difficulty. Therefore, the effects of optimal cytokinin doses and culture media on the germination inhibition and micropropagation of seeds in C. Monogyna were investigated. The germination, shoot formation, and propagation in mature seed embryos were compared in Murashige ve Skoog (MS) and Linsmaier ve Skoog (L&S) nutrient media containing 3 mg/L BA(6-benzyladenine) and 0.5–1–2 mg/L kinetin. It was observed that the culture media influenced germination. The germination rate was higher in the MS medium (100%). Shoot proliferation was higher in MS (4.4 shoots per explant). The highest mean results were obtained in both media containing 3 mg/L BA + 1 mg/L kinetin. Root formation and shoot proliferation occurred in 56% of the explants cultured on the germination medium, and 68% rooting was achieved in the medium supplemented with 1 mg/L indoleacetic acid using the two-stage rooting procedure. Regenerated shoots were successfully rooted and transferred to ex vitro conditions. The results provide a solid basis for testing clonal propagation and efficient generative propagation of selected hawthorn genotypes with fruits of superior quality.Study Implications: In this study, the germination barrier of seeds of Crateagus monogyna was removed by the tissue culture method. The seeds germinated within 1 week. In addition, direct material was obtained for clonal production without the need for rejuvenation studies in micropropagation, and a large number of seedlings were obtained. As a result, it has been determined that this species and similar forest trees can be used in mass production owing to their brief microproduction for the protection of species in forestry and reforestation applications.
Do perceived inequalities in safe water access manifest in collective action? Evidence from urban Ghana
Authors: Achore Meshack , Bisung Elijah 
Published: December 2022

Abstract
Access to safe drinking water is critical in improving health and well-being. It is estimated that &gt;40% of urban households in Ghana do not have access to safe drinking water. Although the willingness and ability of community members to collectively take local initiatives are essential to curtailing inequities in water access in Ghana, the determinant of collective action is less explored. This paper explores determinants of collective action in water-insecure neighbourhoods and examines how perceived inequities in access to water and trust mediate the relationship between lack of access to water and collective action in urban Ghana. The results show that the urban poor OR = 12.047 (p = 0.000) were more likely to participate in water-related collective action compared to wealthy individuals. Primary decision-makers were 1.696 times more likely to participate in collective (p = 0.02). We also found that perceived inequities OR = 0.381 (p = 0.00) significantly predict participation in collective action to address water insecurity. Water service providers should be subjected to a rigid state-level framework that ensures inclusivity, fairness and justice in their distribution systems.
The ‘New’ New Normal—Digitalization and Hybridization of Work and Education Before, during and after the Covid-19 Pandemic
Authors: Gulliksen Jan , Lilliesköld Joakim , Stenbom Stefan 
Published: December 2022

Abstract
Before the COVID-19 coronavirus pandemic, work and education on the university campus were considered superior to equivalent activities conducted digitally or remotely. Despite being significantly digitally mature, many organizations did not consider or even permit digital or hybrid participation in meetings and education. In March 2020, the lockdown following the pandemic caused the transition of many organizations and most universities to online-only operation in record time. Often, this occurred while maintaining quality and production, even if some aspects relating to the user experience were lost. The purpose of this paper is to describe and analyze how digitalization following the pandemic influenced and transformed the digital work environment in higher education. KTH Royal Institute of Technology, Stockholm, Sweden, provided the experiences and data for this article. In conclusion we distinguished different phases of digital work and education before, during and after the pandemic: 1. The Pre-Pandemic Phase, 2. The Emergency Remote Phase, 3. The New Normal, 4. The Slow Acceptance Phase, and 5. The Dividing Phase, or what we refer to as The ‘New’ New Normal. In this phase it looks like it will be a battle between three perspectives; those who are looking to get back to the pre-pandemic conditions, those living in The New Normal, and those actively analyzing the lessons learned and aiming for The Thoughtful Blended Phase. Analyzing these five phases we discern that the implications for the future will be heavily dependent on the following aspects: management commitment and support; well-functioning technology and support organization; understanding the effects digitalization will have on culture, organization and well-being; increasing interest in participating in pedagogical development; new designs needed for hybrid work and education; the need to rethink structure and contents of meetings; and paying extra care and attention to the psychological well-being of staff and students.
Bleeding Complications in Patients With Severe Frostbite Injury
Authors: Murphy Jenna , Endorf Frederick W , Winters M Kenett , Rogers Charlotte , Walter Ellen , Neumann Nichole , Weber Lynn , Lacey Alexandra M , Punjabi Gopal , Nygaard Rachel M 
Published: December 2022

Abstract
Frostbite is caused by exposure to cold temperatures and can lead to severe injury resulting in amputations. Tissue plasminogen activator (tPA) is a thrombolytic agent that has demonstrated efficacy preventing amputation in frostbite patients. The goal of frostbite management with tPA is to salvage tissue without causing clinically significant bleeding complication. The purpose of this study was to characterize bleeding complications in severe frostbite patients managed with and without tPA. Retrospective chart review of severe frostbite patients admitted to a single ABA verified burn center. Bleeding events were grouped: category 0: no bleed; category 1: bleed not resulting in change or intervention; category 2: bleed resulting in change of management; and category 3: bleed resulting in change of management and intervention. Over a 7-year period, 188 patients were included in the study. Most patients had no documentation suggesting a bleeding complication: 69.7% category 0, 19.1% category 1, 4.8% category 2, and 6.4% category 3. There was no significant difference in category 2 or 3 bleeding complications between patients treated with or without tPA. Overall, 9 of the 143 patients (6.3%) treated with tPA had a category 2 or 3 bleeding complication within 12 hours of tPA completion and 12 of 143 (8.4%) within 24 hours of tPA completion. Based on the low risk of severe bleeding and significant benefit relative to limb or digit salvage demonstrated in this study, we conclude that tPA is safe and effective for the treatment of frostbite in appropriately selected patients.
Pore structure and its effect on acoustic velocity and permeability of reef-shoal carbonates in the Tarim Basin, Northwest China
Authors: Zhang Shuxia , Zou Changchun , Peng Cheng , Yan Liwen , Wu Xingwei 
Published: December 2022

Abstract
Experiment and numerical simulation are integrated to investigate the effects of pore structure on physical properties in reef-shoal carbonate samples from the Tarim Basin. The results show three correlation trends between pore structure parameters and physical properties, which closely depend on the pore structure type. The acoustic velocity of the fractured-vuggy type (Structure I) is mainly affected by porosity and pore shape, whereas the fractured and tight types (Structures II and III) are controlled by the pore connection and fractures, respectively. For permeability, the main controlling factor of Structures I and III is porosity, whereas that of Structure II is the volume fraction of fractures. From the pore structure classification, combining pore structure parameters and porosity significantly improves the predictions of acoustic velocity and permeability, confirming that pore structure classification should be prioritized and determining the main controlling factors is critical for the improvement of acoustic velocity and permeability predictions. These results allow better exploration and development of reef-shoal carbonate reservoirs using seismic and acoustic log data.
Lymph-node metastasis from gastric adenocarcinoma in a patient bearing a germ line missense variantMSH2c.1808A &gt; T (Asp603Val) responds to the immune checkpoint inhibitor pembrolizumab
Authors: Kiyomiya Miki , Fukuda Koji , Shimazu Kazuhiro , Yoshida Taichi , Taguchi Daiki , Shinozaki Hanae , Nanjyo Hiroshi , Shibata Hiroyuki 
Published: December 2022

AbstractWe report the sensitivity of immune checkpoint inhibitors for tumors developing in a patient bearing the MSH2 c.1808A &gt; T (Asp603Val) variant belonging to a pedigree of Lynch syndrome. This variant was previously thought to be of unknown significance, but we recently found that this missense mutation was likely pathogenic. At that time, there were no active members with malignancies that could be treated with chemotherapy. Thereafter, an 81-year-old woman bearing this variant, who was a cousin of the proband of this family, had multiple lymph node metastases from her resected gastric cancer. An immune checkpoint inhibitor, pembrolizumab, an anti-PD-1 antibody, was used to treat these tumors. After 3 months of treatment, almost all tumors disappeared, and elevated CA19–9 levels normalized. She survives over 15 months safely. It was indicated that the tumors bearing this germline variant were sensitive to pembrolizumab. This observation suggests that an MSH2 c.1808A &gt; T (Asp603Val) variant induces mismatch repair deficiency, resulting in sensitization to immune checkpoint inhibition.
Site occupancy by American martens and fishers in temperate deciduous forests of Québec
Authors: Suffice Pauline , Mazerolle Marc J , Imbeau Louis , Cheveau Marianne , Asselin Hugo , Drapeau Pierre 
Published: December 2022

AbstractInterspecific interactions can mediate site occupancy of sympatric species and can be a key factor in habitat use patterns. American martens (Martes americana) and Fishers (Pekania pennanti) are two sympatric mesocarnivores in eastern North American forests. Due to their larger size, fishers have a competitive advantage over martens. We investigated site occupancy of martens and fishers in temperate deciduous forests of Québec, an environment modified by forest management and climate change. We formulated hypotheses on the spatial distribution of the studied species based on the knowledge of local trappers and on the scientific literature regarding forest cover composition, habitat fragmentation, and competitive relationships. We used a network of 49 camera traps monitored over two fall seasons to document site occupancy by both species. We used two-species site occupancy models to assess habitat use and the influence of fishers on martens at spatial grains of different sizes. None of the habitat variables that we considered explained site occupancy by fishers. Availability of dense old coniferous stands explained the spatial distribution of martens both at the home range grain size and at the landscape grain size. We identified the characteristics of habitat hotspots based on the knowledge of trappers, which highlighted the importance of stand composition, height, age, and canopy closure. The characteristics of habitat hotspots for martens in temperate deciduous forests refine the habitat suitability model for American martens that was originally developed for boreal forests of Québec.
Multiscale study on the microstructural evolution and macromechanical deterioration of expansive soil under dry–wet cycles
Authors: Zhou Zihao , Bai Yang , Wu Yuntao , Chen Yiqian , Guo Zhuang , Cheng Weikang 
Published: December 2022

Abstract
To explore the influence law of dry–wet cycles on the microstructure of expansive soil and the deterioration effect of macroscopic shear strength, the correlation between the change in the soil internal structure and the deterioration of the mechanical properties is analysed. The expansive soil in the test section of the slope support project in Hanzhong city, Shaanxi Province, China, is selected for sample preparation, three groups of different dry–wet cyclic water content variation paths are defined. The volume damage rate of the soil sample caused by dry–wet cycles is tested, and the microscopic evolution law of soil sample structure was analyzed. On the basis of the conclusion of microscopic analysis, the deterioration effect of macro shear strength of soil samples is further elaborated. The results show that expansive soil is rich in hydrophilic minerals such as illite and montmorillonite. The larger the amplitude of the dry–wet cycle, the more significant the volume change is. With the alternating dry–wet cycle treatment, the microscopic analysis shows that the water migration channels gradually become larger until a new balance is reached. The T2 spectra of the NMR test also show that the overall internal structure develops from stable to unstable. With dry–wet cycles, the unstable change in the soil internal structure leads to the attenuation of the macroscopic shear strength. These micro- and macroscopic research results show that the deterioration effect of drying and wetting on expansive soil cannot be ignored.
Remarks on a New Aramaic Incantation Bowl IM 77781
Authors: Faraj Ali 
Published: December 2022

Abstract
This article presents the edito princeps of a formerly unpublished incantation bowl written in Jewish Babylonian Aramaic. The text consists of fifteen lines and is devoted to protecting the client, his wife and his daughter against the curses of enemies and opponents. The bowl is a gift of Mr. Ismā'īl Nāyf and is part of a collection housed in the Iraq Museum (IM 77781).
Ascending to Jerusalem: On Spatial Cognition, Ideology and Language in the Hebrew Bible
Authors: Lamprecht Adriaan 
Published: December 2022

Abstract
This study focuses on the cognitive relation of interiority between an objective space and an objective ideological schema within the metaphorical use of ascending to Jerusalem. Hitherto, lexicons have failed to consider this specific metaphorical concept's peculiar nuanced distinction within the verb (‘lh)’s horizontal and vertical spatial schemata and the verb (bw’)’s horizontal spatial schemata. Methodologically, this study proposes a cognitive linguistic approach and argues that, apart from the horizontal spatial schemata used by the ancient Hebrew people, it seems that they also utilized unique vertical spatial schemata describing ideological experiences metaphorically.
Long-Term Dynamic of Anti-TrimericS and Anti-RBD Antibodies in Naive and COVID-19 Recovered mRNA-1273 Vaccine Recipients
Authors: Ocmant Annick , Roisin Sandrine , Mathieu Delphine , Brauner Jonathan , De Leener Frédéric 
Published: December 2022

Abstract

Objective
Patients and physicians are increasingly requesting their clinical laboratory to provide SARS-CoV-2 serology interpretation. Our study aimed to assess the evolution of SARS-CoV-2 antibodies in Moderna-vaccinated health care workers.

Methods
We analyzed the evolution of mRNA-1273 (Moderna)–elicited antibodies by 2 high-throughput assays, TrimericS IgG (Diasorin) and SARS-CoV-2 IgG-II (Abbott).

Results
After the first injection, the COVID-19–recovered vaccinees showed a serological response as strong as that observed 1 month after the second injection in participants without COVID-19 history. Although remaining above the positivity thresholds, the TrimericS immunoglobulin G (IgG) and anti-RBD (receptor-binding domain) IgG levels fell considerably between 1 and 7 months postvaccination, dropping to 10.6% and 13% for the COVID-19 recovered subgroup and to 11.7% and 9.3% for the COVID-19 naive subgroup.

Conclusion
Regardless of the test used, a decrease in circulating anti-SARS-CoV-2 IgG levels should be expected a few months after vaccination. As this decline does not preclude the efficacy of immune response, caution is necessary when interpretating postvaccination serological data.
Aseptic meningitis as an initial manifestation of primary Sjögren’s syndrome
Authors: Higashida-Konishi Misako , Akiyama Mitsuhiro , Shimada Tatsuya , Hama Satoshi , Oshige Tatsuhiro , Izumi Keisuke , Oshima Hisaji , Okano Yutaka 
Published: December 2022

ABSTRACT
Aseptic meningitis is a rare life-threatening complication of primary Sjögren’s syndrome (pSS), and its characteristics and prognosis remain unknown. We present our case of aseptic meningitis associated with pSS and reviewed the published literature to elucidate their characteristics and prognosis. An 84-year-old man was admitted to our hospital for fever and disturbance of consciousness. Acute aseptic meningitis was diagnosed based on the results for cerebrospinal fluid and head imaging tests. As an aetiological investigation for his aseptic meningitis, serum anti-Sjögren’s-syndrome–related antigen A and anti-Sjögren’s-syndrome–related antigen B antibodies were found to be positive, and the biopsy specimen of his labial salivary gland revealed lymphocytic sialadenitis, confirming a diagnosis of pSS. Treatment with moderate-dose glucocorticoid completely improved his aseptic meningitis. Relapse of the disease was not observed during his clinical course over 12 months. Our present case and literature review suggest that aseptic meningitis can be an initial manifestation of pSS and be treatable by immunosuppressive therapy. Thus, early recognition and treatment initiation are critical to prevent the irreversible damage of central nervous system in pSS-associated aseptic meningitis. In aseptic meningitis of unknown origin, pSS should be included in differential diagnoses, and testing for serum anti-Sjögren’s-syndrome–related antigen A and anti-Sjögren’s-syndrome–related antigen A antibodies may be useful as an initial screening.
A regulatory loop establishes the link between the circadian clock and abscisic acid signaling in rice
Authors: Wang Yupeng , Wu Fuqing , Lin Qibing , Sheng Peike , Wu Ziming , Jin Xin , Chen Weiwei , Li Shuai , Luo Sheng , Duan Erchao , Wang Jiachang , Ma Weiwei , Ren Yulong , Cheng Zhijun , Zhang Xin , Lei Cailin , Guo Xiuping , Wang Haiyang , Zhu Shanshan , Wan Jianmin 
Published: December 2022

AbstractThere is a close regulatory relationship between the circadian clock and the abscisic acid (ABA) signaling pathway in regulating many developmental processes and stress responses. However, the exact feedback regulation mechanism between them is still poorly understood. Here, we identified the rice (Oryza sativa) clock component PSEUDO-RESPONSE REGULATOR 95 (OsPRR95) as a transcriptional regulator that accelerates seed germination and seedling growth by inhibiting ABA signaling. We also found that OsPRR95 binds to the ABA receptor gene REGULATORY COMPONENTS OF ABA RECEPTORS10 (OsRCAR10) DNA and inhibits its expression. Genetic analysis showed OsRCAR10 acts downstream of OsPRR95 in mediating ABA responses. In addition, the induction of OsPRR95 by ABA partly required a functional OsRCAR10, and the ABA-responsive element-binding factor ABSCISIC ACID INSENSITIVE5 (OsABI5) bound directly to the promoter of OsPRR95 and activated its expression, thus establishing a regulatory feedback loop between OsPRR95, OsRCAR10, and OsABI5. Taken together, our results demonstrated that the OsRCAR10–OsABI5–OsPRR95 feedback loop modulates ABA signaling to fine-tune seed germination and seedling growth, thus establishing the molecular link between ABA signaling and the circadian clock.