bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current and future potential distribution of the invasive scale Ceroplastes rusci (L., 1758) (Hemiptera: Coccidae) under climate niche
Authors: Shan Yiman , Gao Xinyue , Hu Xinyu , Hou Yunfeng , Wang Fang 
Published: November 2022

AbstractBACKGROUNDThe fig wax scale, Ceroplastes rusci is an invasive pest that feeds on more than 94 genera from 52 families that is spread across 60 countries, causing negative impacts to agriculture and forestry. Understanding the potential distribution of invasive species under climate change is crucial for the management and monitoring purposes. Thus, we predicted the potential distribution areas of C. rusci using Maximum Entropy (MaxEnt) based on the occurrence data and environmental variables under current and future climatic scenarios.RESULTSOur results showed that the temperature annual range (Bio 7) and mean temperature of the warmest quarter (Bio 10) attributed to a higher contribution to the current model of the distribution of C. rusci. The potential distribution maps illustrated the main concentrated areas of C. rusci which included South America, Africa, Asia, and Oceania. In addition, potential range expansions or reductions were predicted under different future climate change scenarios, which showed that the total suitable areas of the fig wax scale presented an increasing trend until 2100.CONCLUSIONOur study provides significant data to understand the potential distribution of C. rusci around the world. It also serves as an early warning for the highly suitable habitat areas that even offers a platform to the currently non‐infested regions or countries who are yet to develop monitoring strategies in response to the possible C. rusci outbreak. © 2022 Society of Chemical Industry.
The Immobilized Zirconocene Chloride on Magnetite‐reduced Graphene Oxide: A Highly Efficient and Reusable Heterogeneous Nanocatalyst for One‐pot Three‐component Synthesis of Tetrahydrobenzo[b]pyrans and Dihydropyrano[3,2‐c]chromenes
Authors: Bayzidi Massood , Zeynizadeh Behzad 
Published: November 2022

AbstractThe present paper describes the synthesis and characterization of the functionalized magnetite reduced graphene oxide (rGO@Fe3O4) with zirconocene dichloride as rGO@Fe3O4@ZrCp2Cl2. The prepared magnetic nanomaterial was characterized by Fourier‐transform infrared spectroscopy (FT‐IR), scanning electron microscopy (SEM), energy‐dispersive X‐ray spectroscopy (EDX), X‐ray diffraction (XRD), thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM), inductively coupled plasma optical emission spectroscopy (ICP‐OES) and mass spectrometry (MS). This new heterogeneous nanocatalyst showed the perfect catalytic activity towards synthesis of tetrahydrobenzo[b]pyran and Dihydropyrano[3,2‐c]chromenes derivatives through multicomponent reaction of dimedone or 4‐hydroxycoumarin, malononitrile and aromatic aldehydes in polyethylene glycol 400 (PEG‐400) at 100 °C. The influence of the amount of nanocatalyst, varying temperature of the reaction and the kind of solvent on the rate of condensation reaction was investigated. Recovery and reusability of the applied nanocatalyst was examined for five consecutive cycles without the significant loss of its catalytic activity.
Synthesis and Characterization of 2‐(2‐((1‐Aryl‐1H‐1,2,3‐triazol‐4‐yl)methoxy)phenyl)benzoxazoles: Evaluation of Cytotoxicity and Antioxidant Activity
Authors: Thakral Sumit , Rani Suman , Lal Kashmiri , Kumar Devinder 
Published: November 2022

AbstractA series of twenty 2‐(2‐((1‐aryl‐1H‐1,2,3‐triazol‐4‐yl)methoxy)phenyl) benzoxazoles were synthesized from different aryl azides by copper catalyzed [3+2] cycloaddition reaction in 78–88 % yield. The structure of products was elucidated using spectroscopic techniques. These compounds were tested for cytotoxicity against five cancer cell lines [MCF‐7 (Breast), HT‐29 (Colon), Hep‐G2 (Liver), A549 (Lung) and PC‐3 (Prostate)] using the standard drug Adriamycin. It was found that 2‐(2‐((1‐(3,4‐dichlorophenyl)‐1H‐1,2,3‐triazol‐4‐yl)methoxy)phenyl)benzoxazole (6 g) was active against all the above cancer cell lines with good activity against PC‐3 cancer cell line (GI50 value 60 μM) comparative to Adriamycin (GI50 value 0.3 μM). Compound 6 g also displayed significant antioxidant activity (IC50 value 4.56 μM) as compared to standard ascorbic acid (IC50 value 9.10 μM).
Nano‐Theranostic Modality for Visualization of the Placenta and Photo‐Hyperthermia for Potential Management of Ectopic Pregnancy
Authors: Moses Abraham S. , Kadam Leena , St Lorenz Anna , Baldwin Maureen K. , Morgan Terry , Hebert Jessica , Park Youngrong , Lee Hyelim , Demessie Ananiya A. , Korzun Tetiana , Mamnoon Babak , Alani Adam W. G. , Taratula Oleh , Myatt Leslie , Taratula Olena R. 
Published: November 2022

AbstractEctopic pregnancy (EP) is the leading cause of maternity‐related death in the first trimester of pregnancy. Approximately 98% of ectopic implantations occur in the fallopian tube, and expedient management is crucial for preventing hemorrhage and maternal death in the event of tubal rupture. Current ultrasound strategies misdiagnose EP in up to 40% of cases, and the failure rate of methotrexate treatment for confirmed EP exceeds 10%. Here the first theranostic strategy for potential management of EP is reported using a near‐infrared naphthalocyanine dye encapsulated within polymeric nanoparticles. These nanoparticles preferentially accumulate in the developing murine placenta within 24 h following systemic administration, and enable visualization of implantation sites at various gestational stages via fluorescence and photoacoustic imaging. These nanoparticles do not traverse the placental barrier to the fetus or impact fetal development. However, excitation of nanoparticles localized in specific placentas with focused NIR light generates heat (>43 °C) sufficient for disruption of placental function, resulting in the demise of targeted fetuses with no effect on adjacent fetuses. This novel approach would enable diagnostic confirmation of EP when current imaging strategies are unsuccessful, and elimination of EP could subsequently be achieved using the same nano‐agent to generate localized hyperthermia resulting in targeted placental impairment.
Versatile MXene integrated assembly for piezoresistive micro‐force sensing
Authors: Wang Shenglong , Lan Boling , Gao Yuyu , Xie Yanting , He Hanyu , Xiong Da , Tian Guo , Yang Tao , Huang Junfeng , Ao Yong , Sun Yue , Yang Weiqing , Deng Weili 
Published: November 2022

AbstractMXenes have received tremendous attention for flexible electronics owing to their excellent conductivity, water dispersibility, and mechanical flexibility. However, the sediment from the MXene production process is usually discarded as trash, resulting in low utilization. Here, we present a flexible pressure sensor that enables micro‐force sensing and efficient utilization of MXene by confining MXene trash among structured MXene electrodes. Benefiting from the synergistic effect of both the confined micro‐conical structure and easily changeable space of MXene trash, the as‐designed device can detect extremely subtle pressure of 2.9 Pa, deliver a high sensitivity over 4.08 kPa−1, and exhibit a remarkably fast response time (7 ms). These properties make it suitable for monitoring weak force signals from human wrist pulse and even for detecting dynamic responses associated with acoustic waves. This work provides a reference for the versatile and efficient application of MXene in the same device, showing great potential for sustainable production of next‐generation wearable smart electronics.
2D nonlocal elasticity: Investigation of stress and strain fields in complex shape regions
Authors: Kuvyrkin Georgy Nikolaevich , Savelyeva Inga Yurievna , Sokolov Andrey Alexandrovich 
Published: November 2022

AbstractThe paper presents the features of solutions to nonlocal elasticity problems in domains with stepped transitions and elliptical notches. A comparative analysis of the solutions obtained in the classical and nonlocal elasticity theories was carried out, as well as an analysis of the influence of the main parameters of the model on the final results. The presented solutions for the region with a step transition are in qualitative agreement with the experimental data and have similar portraits of deformations and resultant stresses along the loading axis. In regions with elliptical notches, similar effects are observed. In addition to qualitative agreement with experiments, solutions in the nonlocal formulation have lower stress values in the concentrators and exhibit edge effects, which are characterized by sharp stress and strain gradients at the domain boundaries. The solutions were carried out numerically by the finite element method.
Religious/Spiritual Development and Positive Psychology: Toward an Integrative Theory
Authors: Davis Edward B. , Day James M. , Lindia Philip A. , Lemke Austin W. 
Published: November 2022

AbstractThroughout the history of psychology, scholars and practitioners have sought to understand religious/spiritual (R/S) development and its intersections with well-being. Several models of R/S development have been proposed, but they have neither been well-integrated with each other nor studied and applied broadly in the field of positive psychology. This chapter’s purpose is to draw on existing longitudinal research on R/S development to propose an integrative theory that can guide developmental science and practice on religion, spirituality, and positive psychology. This Positive Religious and Spiritual Development (PRSD) theory posits that people’s religiousness/spirituality (a) is motivated by goals designed to meet psychological needs (e.g., for acceptance, predictability, and competence); (b) consists of mental/neural representations (stored beliefs, emotions, action tendencies, and physiological responses) and R/S habits that develop and change through relational experiences at the micro-, meso-, and macrolevels; (c) is influenced by numerous contextual factors (e.g., age, sex/gender, culture, and faith tradition), including personal and sociocultural assets and liabilities (risk and resilience factors); and (d) interacts bidirectionally with people’s holistic well-being via psychological, social, behavioral, and physical pathways. We offer illustrative examples of PRSD theory, highlight some of its caveats and limitations, and discuss its applications for clinical practice and religious ministry.
Meaning as a Framework for Integrating Positive Psychology and the Psychology of Religiousness and Spirituality
Authors: Park Crystal L. , Van Tongeren Daryl R. 
Published: November 2022

AbstractBoth the subfields of positive psychology (PP) and the psychology of religiousness and spirituality (PRS) are producing interesting, relevant, and impactful research, but very little integration of this research occurs between these subfields. We propose that a meaning system framework may be useful in unifying science and practice at the intersection of PP and PRS. In this chapter, we describe this meaning systems framework and summarize each subfield’s key meaning-related areas of focus, methods, and applications. We then highlight the convergences and divergences in these key areas of both subfields. We conclude that meaning is a unifying construct around which future theory and empirical research on PP and PRS can coalesce, and we propose some specific directions for a fruitful integration of these two subfields.
Large N expansion of an integrated correlator in $$ \mathcal{N} $$ = 4 SYM
Authors: Hatsuda Yasuyuki , Okuyama Kazumi 
Published: November 2022

Abstract
Recently Dorigoni, Green and Wen conjectured a remarkable exact formula for an integrated correlator of four superconformal primary operators in $$ \mathcal{N} $$
N
= 4 supersymmetric Yang-Mills theory. In this work, we investigate its large N limit in detail. We show that the formula of Dorigoni, Green and Wen can be recast into the sum over the contributions of (p, q)-strings via the holography in the large N limit. Due to the SL(2, ℤ) duality, all the contributions are governed by a single function, typically appearing as the fundamental string contribution. The large order behavior for the perturbative genus expansion of this function allows us to reveal the large N non-perturbative corrections. The same result is obtained more systematically by using a Laplace-difference equation for the integrated correlator.
Hermitian K-theory for stable $$\infty $$-categories I: Foundations
Authors: Calmès Baptiste , Dotto Emanuele , Harpaz Yonatan , Hebestreit Fabian , Land Markus , Moi Kristian , Nardin Denis , Nikolaus Thomas , Steimle Wolfgang 
Published: November 2022

AbstractThis paper is the first in a series in which we offer a new framework for hermitian$${\text {K}}$$K-theory in the realm of stable$$\infty $$∞-categories. Our perspective yields solutions to a variety of classical problems involving Grothendieck-Witt groups of rings and clarifies the behaviour of these invariants when 2 is not invertible. In the present article we lay the foundations of our approach by considering Lurie’s notion of a Poincaré$$\infty $$∞-category, which permits an abstract counterpart of unimodular forms called Poincaré objects. We analyse the special cases of hyperbolic and metabolic Poincaré objects, and establish a version of Ranicki’s algebraic Thom construction. For derived$$\infty $$∞-categories of rings, we classify all Poincaré structures and study in detail the process of deriving them from classical input, thereby locating the usual setting of forms over rings within our framework. We also develop the example of visible Poincaré structures on$$\infty $$∞-categories of parametrised spectra, recovering the visible signature of a Poincaré duality space. We conduct a thorough investigation of the global structural properties of Poincaré$$\infty $$∞-categories, showing in particular that they form a bicomplete, closed symmetric monoidal$$\infty $$∞-category. We also study the process of tensoring and cotensoring a Poincaré$$\infty $$∞-category over a finite simplicial complex, a construction featuring prominently in the definition of the$${\text {L}}$$L- and Grothendieck-Witt spectra that we consider in the next instalment. Finally, we define already here the 0th Grothendieck-Witt group of a Poincaré$$\infty $$∞-category using generators and relations. We extract its basic properties, relating it in particular to the 0th$${\text {L}}$$L- and algebraic$${\text {K}}$$K-groups, a relation upgraded in the second instalment to a fibre sequence of spectra which plays a key role in our applications.
Importance of beta cell mass for glycaemic control in people with type 1 diabetes
Authors: Jansen Theodorus J. P. , Brom Maarten , Boss Marti , Buitinga Mijke , Tack Cees J. , van Meijel Lian A. , de Galan Bastiaan E. , Gotthardt Martin 
Published: November 2022

Abstract
Aims/hypothesis
The role of beta cell mass in the balance of glucose control and hypoglycaemic burden in people with type 1 diabetes is unclear. We applied positron emission tomography (PET) imaging with radiolabelled exendin to compare beta cell mass among people with type 1 diabetes and either low glucose variability (LGV) or high glucose variability (HGV).

Methods
All participants with either LGV (n=9) or HGV (n=7) underwent a mixed-meal tolerance test to determine beta cell function and wore a blinded continuous glucose monitor for a week. After an i.v. injection with [68Ga]Ga-NODAGA-exendin-4, PET images were acquired for the quantification of pancreatic uptake of radiolabelled exendin. The mean standardised uptake value (SUVmean) of the pancreas was used to determine the amount of beta cell mass.

Results
Participants with LGV had lower HbA1c (46.0 mmol/mol [44.5–52.5] [6.4% (6.3–7)] vs 80 mmol/mol [69.0–110] [9.5% (8.5–12.2)], p=0.001) and higher time in range (TIR) (75.6% [73.5–90.3] vs 38.7% [25.1–48.5], p=0.002) than those with HGV. The SUVmean of the pancreas was higher for the LGV than for the HGV group (5.1 [3.6–5.6] vs 2.9 [2.1–3.4], p=0.008). The AUCC-peptide:AUCglucose ratio was numerically, but not statistically, higher in the LGV compared with the HGV group (2.7×10−2 [6.2×10−4–5.3×10−2] vs 9.3×10−4 [4.7×10−4–5.2×10−3], p=0.21). SUVmean correlated with the AUCC-peptide:AUCglucose ratio (Pearson r=0.64, p=0.01), as well as with the TIR (r=0.64, p=0.01) and the SD of interstitial glucose levels (r=−0.66, p=0.007).

Conclusion/interpretation
Our data show higher beta cell mass in people with type 1 diabetes and LGV than in those with HGV, independent of beta cell function.

Graphical abstract
Mergers and bank branches: two decades of evidence from the USA
Authors: Calzada Joan , Fageda Xavier , Martínez-Santos Fernando 
Published: November 2022

AbstractIn recent decades, the US bank market has been exposed to several waves of mergers, resulting in concerns about branch presence and consumer access to financial services. This paper examines the effects of bank mergers on branch density in the period 2000–2020. To do so, we use panel regressions and matching techniques at the census tract level to study the impact of inter- and intrastate mergers before and after the Great Recession of 2007. To generate plausible exogenous variation for mergers, our analysis focuses on transactions involving large entities, and we consider the within-tract variation in exposure to mergers. A comparison of exposed and unexposed tracts shows that in the period under study each merger reduced branch density by around 3%. Moreover, interstate mergers reduced branch density at the tract level across the whole period but had an expansionary effect on the number of branches at the county level before the crisis. Intrastate mergers, in contrast, had a consolidation effect across the whole period, an impact that was more intense in rural tracts and in tracts where merging entities operated overlapping branch networks. Finally, we show that the reduction of bank branches was stronger in tracts with a relatively higher penetration of broadband Internet services, but we find no evidence that the adoption of FinTech services intensified branch closures.
Leflunomide abrogates neuroinflammatory changes in a rat model of Alzheimer’s disease: the role of TNF-α/NF-κB/IL-1β axis inhibition
Authors: Nafea Menna , Elharoun Mona , Abd-Alhaseeb Mohammad Mohmoud , Helmy Maged Wasfy 
Published: November 2022

AbstractAlzheimer’s disease (AD) is one of the most common neurodegenerative diseases and is associated with disrupted cognition and behavior. Neuroinflammatory pathogenesis is the main component that contributes to AD initiation and progression through microglial activation and neuronal damage. Thus, targeting inflammatory pathways may help manage AD. In this study, for the first time, the potential prophylactic and therapeutic effects of leflunomide were investigated either alone or in combination with rivastigmine in aluminum chloride (AlCl3)-induced AD-like rats using behavioral, biochemical, and histological approaches. Thirty-six adult male albino rats were divided into two protocols: the treatment protocol, subdivided into five groups (n = 6)—(1) control group, (2) AlCl3 (50, 70, 100 mg/kg/I.P) group, (3) reference group (rivastigmine 2 mg/kg/P.O.), (4) experimental group (leflunomide 10 mg/kg/P.O.), and (5) combination group (rivastigmine + leflunomide); and the prophylactic protocol (leflunomide 10 mg/kg/P.O.), which started 2 weeks before AlCl3 induction. The results showed that AlCl3 disrupted learning and memory parameters in rats and increased amyloid-β plaque deposition and neurofibrillary tangle aggregation. Moreover, AlCl3 administration markedly elevated acetylcholinesterase activity, nuclear factor-kappa β, tumor necrosis factor-α, and interleukin-1 beta, and marked degenerative changes in the pyramidal neurons. However, administration of leflunomide alone or with rivastigmine in AlCl3-induced AD rats restored most of the behavioral, biochemical, and histological parameters triggered by AlCl3 in rats. Our findings suggest that leflunomide can potentially restore most of the neuronal damage in the hippocampal tissues of AlCl3-induced AD rats. However, these preclinical findings still need to be confirmed in clinical trials.
Bioactive compounds, pharmacological actions and pharmacokinetics of Cupressus sempervirens
Authors: Batiha Gaber El-Saber , Teibo John Oluwafemi , Shaheen Hazem M. , Akinfe Opeyemi Abigail , Awad Aya Ahmed , Teibo Titilade Kehinde Ayandeyi , Alexiou Athanasios , Papadakis Marios 
Published: November 2022

AbstractThe roles of plants and its products in all forms of life cannot be overemphasized. The medicinal products from plant are phytochemicals, drugs, food supplements, beauty products, etc. In ethnomedicine, leaves, fruits, stem, bark, root and fluids from plants are used in the cure, management and prevention of several diseases. Cupressus sempervirens, sometimes called Italian or Mediterranean cypress, is found in subtropical Asia, North America and eastern Mediterranean region. Pharmacological investigations of Cupressus sempervirens showed biological properties such as aromatherapeutic, antiseptic, astringent, balsamic or anti-inflammatory, astringent, antiperspirant, diuretic and antispasmodic. Chemical analysis of Cupressus sempervirens gives phytochemicals like monoterpenes, diterpenes, flavonoid glycosides and bioflavonoids. The current review highlights interactions, conventional uses and biological actions of Cupressus sempervirens plant and plant products.
Brief report: STING expressed in tumor and non-tumor compartments has distinct roles in regulating anti-tumor immunity
Authors: Kim Jennie C. , Liu Xian , Fitzgerald Karen , Eng Jason S. , Orf Jessica , O’Brien Sarah A. , Belmontes Brian , Casbon Amy-Jo , Novitskiy Sergey V. , Tarbell Kristin V. , DeVoss Jason , Egen Jackson G. 
Published: November 2022

AbstractType I interferon-mediated activation of immune cells can facilitate the generation of productive tumor antigen-specific T cell responses in solid tumors. The cGAS/STING DNA sensing pathway is a critical upstream mediator of type I interferon production and is an important regulator of anti-tumor immunity. Numerous STING pathway agonists are now being tested in clinical trials, but the effectiveness of this approach is not yet clear and a better understanding of the relative importance of this pathway in various tumor settings is needed. We have evaluated syngeneic tumor models with different baseline inflammatory states to determine the contributions of STING activity in both tumor and non-tumor cellular compartments to anti-tumor immune responses. We find that productive anti-tumor immune responses in the poorly immunogenic B16F10 model show a strong dependence on STING expression in non-tumor cells. In the immunogenic MC38 model, constitutive STING activation in tumor cells can partially bypass the requirement for STING-dependent activity from immune cells. Our findings reveal multiple, context-dependent roles for STING activity in the regulation of anti-tumor immunity and the response to immunotherapy. In preclinical models where STING is basally active, checkpoint inhibition is more likely to have a therapeutic effect and removal of STING signaling from either the tumor or the non-tumor compartment has a minimal effect. Removal of STING signaling in both, however, diminishes the efficacy derived from checkpoint therapy. Further work is needed to understand the heterogeneity of STING signaling in patients, both in tumor cells and the tumor microenvironment, and the best means of harnessing this pathway to generate anti-tumor immunity and improve therapeutic outcomes.