bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of antithrombotic therapy in patients at high bleeding risk after percutaneous coronary intervention for acute coronary syndromes: a case report
Authors: Mahmood Hamid , Shahid Farhan , Egred Mohaned , Farag Mohamed 
Published: June 2022

AbstractBackgroundChoosing antithrombotic therapy for patients at high bleeding risk, particularly those requiring long-term anticoagulant therapy, who have acute coronary syndromes (ACS) and/or undergoing percutaneous coronary intervention (PCI) is becoming increasingly complex.Case summaryA 78-year-old women was hospitalized with chest pain and a diagnosis of non-ST-elevation ACS was made. It was decided that the patient should undergo coronary angiogram with a view for angioplasty. Subsequently, she underwent successful PCI to the left anterior descending artery. Shortly after PCI, she was noted to be in atrial fibrillation. Furthermore, she had per rectal bleeding and acute kidney injury, which were managed conservatively. Aspirin and ticagrelor were stopped and she was discharged on dual antithrombotic therapy with clopidogrel and apixaban.DiscussionAvailable evidence, driven mainly from expert consensus documents, advocates a case-by-case comprehensive evaluation that integrates patient- and procedure-related factors to assess patients for thrombotic and bleeding tendencies to identify those who may gain most net clinical benefit of antithrombotic combination therapy. In general, if thrombotic drivers prevail, an augmented antithrombotic regime with a view for a longer duration should be planned, and if bleeding drivers prevail, a de-escalated regime with a view for a shorter duration should be sought.
Early Retirement and Social Class: A Health-Giving Choice for All?
Authors: Qvist Jeevitha Yogachandiran 
Published: June 2022

AbstractEmpirical evidence on the effect of the timing of retirement on post-retirement health is so far inconclusive regarding the causal nature of this relationship, and little is known about how the effect varies by social class. This paper uses birth cohort variation in incentives to postpone early retirement in an instrumental variable framework to estimate the causal effect of early retirement on post-retirement health as indicated by visits to general practitioners (GP) and mortality. Drawing on Danish administrative register data, results from instrumental variable regressions suggest that for men, the effect of early retirement at age 60 on GP visits is positive and short-term, if anything, as it reduces early retirees’ number of visits to the GP compared to men who retire later than at age 60. These effects, among men, are particularly driven by members of the skilled manual working class. For women, the results show no evidence of a health effect of early retirement on GP visits. Additionally, for mortality, the results provided no evidence of a health effect of early retirement, irrespective of social class and gender.
Family Background, Educational Qualifications, and Labour Market Attainment: Evidence from Danish Siblings
Authors: Karlson Kristian Bernt , Birkelund Jesper Fels 
Published: June 2022

AbstractPrevious studies on how family background affects labour market outcomes among offspring with similar formal educational qualifications are limited either by the way in which they measure family background or by the detail level by which they measure educational attainment. To address these limitations, we develop a comprehensive approach based on sibling similarities in labour market outcomes. Applying the approach to high-quality register data on all Danes born 1965–1971, we examine the direct effect––other than through extremely granular education measures––of all combined effects of family background on occupational status and wages. Our analyses show that fine-grained education measures account for more than 90 per cent of the total family background effect on occupational status, while for wages they account for merely three-quarters. Half of the direct effect on wages can be explained by sibling similarities in occupational attainment, suggesting that direct family background effects on wages operate equally within and between occupations. However, observed family background characteristics account only for a minor portion of the direct effect on wages, pointing to that family-based advantages in the labour Danish market result from largely unidentified family characteristics. We discuss different mechanisms that may account for this pattern of results.
Characterization of a gene cluster involved in Aspergillus fumigatus zwitterionic glycosphingolipid synthesis
Authors: Seegers Carla I I , Ramón Roth Isabel , Zarnovican Patricia , Buettner Falk F R , Routier Françoise H 
Published: June 2022

Abstract
The human pathogenic fungus Aspergillus fumigatus synthesizes the zwitterionic glycolipid Manα1,3Manα1,6GlcNα1,2IPC, named Af3c. Similar glycosphingolipids having a glucosamine (GlcN) linked in α1,2 to inositolphosphoceramide (IPC) as core structure have only been described in a few pathogenic fungi. Here, we describe an A. fumigatus cluster of 5 genes (AFUA_8G02040 to AFUA_8G02090) encoding proteins required for the glycan part of the glycosphingolipid Af3c. Besides the already characterized UDP-GlcNAc:IPC α1,2-N-acetylglucosaminyltransferase (GntA), the cluster encodes a putative UDP-GlcNAc transporter (NstA), a GlcNAc de-N-acetylase (GdaA), and 2 mannosyltransferases (OchC and ClpC). The function of these proteins was inferred from analysis of the glycolipids extracted from A. fumigatus strains deficient in one of the genes. Moreover, successive introduction of the genes encoding GntA, GdaA, OchC, and ClpC in the yeast Saccharomyces cerevisiae enabled the reconstitution of the Af3c biosynthetic pathway. Absence of Af3c slightly reduced the virulence of A. fumigatus in a Galleria mellonella infection model.
Integrated delivery of family planning and childhood immunization services: a qualitative study of factors influencing service responsiveness in Malawi
Authors: Hamon Jessie K , Kambanje Misozi , Pryor Shannon , Kaponda Alice S , Mwale Erick , Mayhew Susannah H , Webster Jayne , Burchett Helen E D 
Published: June 2022

Abstract
Evidence from several countries in sub-Saharan Africa suggests that the integration of family planning (FP) with childhood immunization services can help reduce the unmet need for FP among postpartum women without undermining the uptake of immunizations. However, the quality and responsiveness of FP services that are integrated with childhood immunizations remain understudied. A qualitative study was conducted in two districts of Malawi, which examined the factors influencing the responsiveness of FP services that were integrated with childhood immunizations in monthly public outreach clinics. Semi-structured interviews with clients (n = 23) and FP providers (n = 10) and a clinic audit were carried out in six clinics. Hardware (material) and software (relational) factors influencing service responsiveness were identified through thematic and framework analyses of interview transcripts, and clinic characteristics were summarized from the audit data to contextualize the qualitative findings. Overall, 13 factors were found to influence service responsiveness in terms of the ease of access, choice of provider, environment, service continuity, confidentiality, communication, dignity and FP counselling afforded to clients. Among these factors, hardware deficiencies, including the absence of a dedicated building for the provision of FP services and the lack of FP commodities in clinics, were perceived to negatively affect service responsiveness. Crucially, the providers’ use of their agency to alter the delivery of services was found to mitigate the negative effects of some hardware deficits on the ease of access, choice of provider, environment and confidentiality experienced by clients. This study contributes to an emerging recognition that providers can offset the effect of hardware deficiencies when services are integrated if they are afforded sufficient flexibility to make independent decisions. Consideration of software elements in the design and delivery of FP services that are integrated with childhood immunizations is therefore critical to optimize the responsiveness of these services.
Oxytocinergic Modulation of Stress-Associated Amygdala-Hippocampus Pathways in Humans Is Mediated by Serotonergic Mechanisms
Authors: Lan Chunmei , Liu Congcong , Li Keshuang , Zhao Zhiying , Yang Jiaxin , Ma Yina , Scheele Dirk , Yao Shuxia , Kendrick Keith M , Becker Benjamin 
Published: June 2022

AbstractBackgroundThe hypothalamic neuropeptide oxytocin (OXT) may exert anxiolytic and stress-reducing actions via modulatory effects on amygdala circuits. Animal models and initial findings in humans suggest that some of these effects are mediated by interactions with other neurotransmitter systems, in particular the serotonin (5-HT) system. Against this background, the present pharmacological resting-state functional magnetic resonance imaging study aimed to determine whether effects of OXT on stress-associated amygdala intrinsic networks are mediated by 5-HT.MethodsWe employed a randomized, placebo-controlled, double-blind parallel-group, pharmacological functional magnetic resonance imaging resting-state experiment with 4 treatment groups in n = 112 healthy male participants. Participants underwent a transient decrease in 5-HT signaling via acute tryptophan depletion (ATD) or a corresponding placebo-control protocol before the administration of intranasal OXT (24 IU) or placebo intranasal spray.ResultsOXT and 5-HT modulation exerted interactive effects on the coupling of the left amygdala with the ipsilateral hippocampus and adjacent midbrain. OXT increased intrinsic coupling in this pathway, whereas this effect of OXT was significantly attenuated during transiently decreased central serotonergic signaling induced via acute tryptophan depletion. In the absence of OXT or 5-HT modulation, this pathway showed a trend for an association with self-reported stress perception in everyday life. No interactive effects were observed for the right amygdala.ConclusionsTogether, the findings provide the first evidence, to our knowledge, that the effects of OXT on stress-associated amygdala-hippocampal-midbrain pathways are critically mediated by the 5-HT system in humans.
Seroepidemiological Reconstruction of Long-term Chikungunya Virus Circulation in Burkina Faso and Gabon
Authors: Lim Jacqueline Kyungah , Ridde Valery , Agnandji Selidji Todagbe , Lell Bertrand , Yaro Seydou , Yang Jae Seung , Hoinard Damien , Weaver Scott C , Vanhomwegen Jessica , Salje Henrik , Yoon In-Kyu 
Published: June 2022

Abstract
Chikungunya virus (CHIKV) is a major public health concern worldwide. However, infection levels are rarely known, especially in Africa. We recruited individuals from Ouagadougou, Burkina Faso and Lambaréné, Gabon (age range, 1–55 years), tested their blood for CHIKV antibodies, and used serocatalytic models to reconstruct epidemiological histories. In Ouagadougou, 291 of 999 (29.1%) individuals were seropositive, ranging from 2% among those aged &lt;10 years to 66% in those aged 40–55 years. We estimated there were 7 outbreaks since the 1970s but none since 2001, resulting in 600 000 infections in the city, none of which were reported. However, we could not definitively conclude whether infections were due to CHIKV or o’nyong-nyong, another alphavirus. In Lambaréné, 117 of 427 (27%) participants were seropositive. Our model identified a single outbreak sometime since 2007, consistent with the only reported CHIKV outbreak in the country. These findings suggest sporadic outbreaks in these settings and that the burden remains undetected or incorrectly attributed.
Fighting a Plague: Doctors' Stories of Challenge and Innovation Combatting the AIDS Epidemic in 1980s New York City
Authors: DeVita Timothy N 
Published: June 2022

Abstract
The human immunodeficiency virus (HIV) has devastated the United States for forty years. Though there are highly effective treatments for HIV and acquired immune deficiency syndrome (AIDS) today, the early years of the HIV/AIDS epidemic in New York City (NYC) were filled with uncertainty, fear, and death—not unlike the period we are now experiencing in the COVID-19 era. Existing scholarship captures the political discourse of the HIV/AIDS era and the narratives of physicians who specialized in HIV medicine. This essay uses eight in-depth interviews of physicians of various specialties who worked in NYC to understand the uncertainties and fears in daily work during the early AIDS epidemic. Their stories provide unique perspectives into the realities of working as physicians in the epicenter of a highly politicized epidemic with limited support, information, and treatments. They illustrate that HIV/AIDS provided unique biomedical, social, and political challenges to the physicians working in NYC during the 1980s. Over the course of the decade, these physicians adapted to meet challenges using methods that have since become commonplace in their clinical practice.
Real-time scanning electron microscopy of unfixed tissue in the solution using a deformable and electron-transmissive film
Authors: Shintani Seine A , Yamaguchi Seiji , Takadama Hiroaki 
Published: June 2022

Abstract
It is difficult to use scanning electron microscopy to observe the structure and movement of biological tissue immersed in the solution. To enable such observations, we created a highly deformable and electron-transmissive polyimide film that can withstand the pressure difference between the high-vacuum electron column and the atmospheric-pressure sample chamber. With this film, we used scanning electron microscopy to measure the intrinsic fine structure and movement of the contractile fibers of excised mouse heart immersed in physiological solutions. Our measurements revealed that the excised heart is a dynamic tissue that undergoes relaxation oscillation based on a three-dimensional force balance.
Selection and Appointment in International Adjudication: Insights from Political Science
Authors: Larsson Olof , Squatrito Theresa , Stiansen Øyvind , St John Taylor 
Published: June 2022

Abstract
This article summarizes insights from political science and empirical legal scholarship concerning selection and appointment of adjudicators to permanent international courts (ICs). This scholarship suggests that designers of ICs face challenging trade-offs in balancing judicial independence and accountability, as well as in promoting descriptive representation and necessary qualifications on the bench. The article considers different institutional design features related to appointment procedures: representation, reappointment, screening procedures and procedures for removing judges. Representation is discussed in a series of sections considering full or selective representation, voting rules and geographic and gender quotas and aspirational targets. Throughout, we draw on data on 24 ICs to illustrate the different appointment procedures and institutional features.
Refugee Participation through Representative Committees: UNHCR and the Sudanese Committee in Beirut
Authors: Janmyr Maja 
Published: June 2022

Abstract
The notions of refugee participation and empowerment are core—but highly debated and poorly implemented—standards of humanitarian response. Drawing on empirical research in Lebanon, this article offers an account of the ways in which—and which not—meaningful refugee participation and empowerment are achieved through representative committees. Spotlighting the case of the United Nations High Commissioner for Refugees (UNHCR)-supported Sudanese refugee committee in Beirut 2014–2015, it focuses on three intricate and interrelated concerns—refugee participation, representation, and autonomy. The article finds that the design and function of the committee made it difficult for refugees to share authority with UNHCR over decisions that impact their lives. The committee was primarily seen by UNHCR as a good in and of itself rather than as an opportunity to actively involve refugees in decision-making processes. The article suggests that there is ample room for the development of more meaningful participation that better integrates the capabilities, preferences, and agencies of persons living as refugees.
Axillary intra-aortic balloon pump, biventricular assist device implantation and subsequent orthotopic heart transplantation in a patient with sickle cell trait
Authors: Taylor Marcus , Mouyer Zakariya , Callan Paul , Shaw Steve , Venkateswaran Rajamiyer , Nwaejike Nnamdi 
Published: June 2022

Abstract
A 38-year-old male with sickle cell trait and acute refractory heart failure received an axillary intra-aortic balloon pump and short-term biventricular assist device. He underwent orthotopic heart transplantation 45 days later, which was complicated by major bleeding necessitating significant intra-operative transfusion. Support with veno-arterial extracorporeal membrane oxygenation was provided and successfully weaned five days later. He made a full recovery and remains alive and well 34 months after discharge. We hypothesize that the protective peri-operative measures undertaken, including normothermia during surgery and post-operative haemodynamic stability due to the use of mechanical circulatory support, conveyed a degree of protection against complications associated with sickle cell dysfunction and contributed to the successful outcome.
Application of the Fluorescence Method on Sysmex XN9000 Hematology Analyzer for Correcting Platelet Count in Individuals with Microcytosis
Authors: Deng Jiankai , Xie Shuhua , Chen Yaoming , Ma Qinghua , He Yuting , Liu Min , Wang Dong , Yu Xuegao 
Published: June 2022

AbstractObjectiveAlthough small red blood cells are a well-known analytical pitfall that could cause artifactual increase of the platelet count, limited information is available on the accuracy of impedance platelet counting in cases with microcytosis. The aim of this study is to assess the accuracy of impedance platelet counting in the presence of small red blood cells, and to establish the optimal mean corpuscular volume (MCV) cutoff to endorse fluorescence platelet counting.MethodsIn this study, platelet counts estimated by the impedance method on the Sysmex XN9000 analyzer (Sysmex, Kobe, Japan) were compared with those provided by the fluorescence method. The accuracy of impedance platelet counting was assessed. Receiver operating characteristic curve was used to evaluate the performance of MCV in predicting falsely increased platelet counts.ResultsThere was a tendency for the impedance method to overestimate the platelet count in samples with 70 fL &lt; MCV ≤ 80 fL, 60 fL &lt; MCV ≤ 70 fL, MCV ≤ 60 fL. Receiver operating characteristic curve analysis showed that a 73.5fL cutoff of MCV was highly sensitive in predicting falsely increased platelet counts.ConclusionIn cases with MCV &lt; 73.5 fL, we strongly suggest that the platelet counts obtained by the impedance method on the Sysmex XN9000 analyzer should be checked and corrected by fluorescence counting.
Aspergillosis in a colony of Humboldt penguins (Spheniscus humboldti) under managed care: a clinical and environmental investigation in a French zoological park
Authors: Cateau Estelle , Leclerc Antoine , Cartier Noémie , Valsecchi Isabel , Bailly Éric , Le Senechal Ronan , Becerra Margaux , Le Gallou Brice , Lavergne Rose-Anne , Chesnay Adélaïde , Robin Jean-Patrice , Cray Carolyn , Goddard Nicolas , Thorel Milan , Guillot Jacques , Mulot Baptiste , Desoubeaux Guillaume 
Published: June 2022

AbstractAspergillosis is pervasive in bird populations, especially those under human care. Its management can be critically impacted by exposure to high levels of conidia and by resistance to azole drugs. The fungal contamination in the environment of a Humboldt penguin (Spheniscus humboldti) group, housed in a French zoological park next to numerous large crop fields, was assessed through three serial sessions of surface sampling in nests, in 2018–20: all isolates were counted and characterized by sequencing. When identified as Aspergillus fumigatus, they were systematically screened for resistance mutations in the cyp51A gene and tested for minimal inhibitory concentrations (MICs) determination. At the same time, the clinical incidence of aspergillosis was evaluated in the penguin population by the means of systematic necropsy and mycological investigations. A microsatellite-based analysis tracked the circulation of A. fumigatus strains. Environmental investigations highlighted the substantial increase of the fungal load during the summer season (&gt;12-fold vs. the other timepoints) and a large overrepresentation of species belonging to the Aspergillus section Fumigati, ranging from 22.7 to 94.6% relative prevalence. Only one cryptic species was detected (A. nishimurae), and one isolate exhibited G138S resistance mutation with elevated MICs. The overall incidence of aspergillosis was measured at ∼3.4% case-years, and mostly in juveniles. The analysis of microsatellite polymorphism revealed a high level of genetic diversity among A. fumigatus clinical isolates. In contrast, one environmental strain appeared largely overrepresented during the summer sampling session. In all, the rural location of the zoo did not influence the emergence of resistant strains.Lay summary
Resonant shattering flares in black hole-neutron star and binary neutron star mergers
Authors: Neill Duncan , Tsang David , van Eerten Hendrik , Ryan Geoffrey , Newton William G 
Published: June 2022

ABSTRACT
Resonant shattering flares (RSFs) are bursts of gamma-rays expected to be triggered by tidal resonance of a neutron star (NS) during binary inspiral. They are strongly dependent on the magnetic field strength at the surface of the NS. By modelling these flares as being the result of multiple colliding relativistic shells launched during the resonance window, we find that the prompt non-thermal gamma-ray emission may have luminosity up to a few $\times 10^{48}\rm{ erg\,s}^{-1}$, and that a broad-band afterglow could be produced. We compute the expected rates of detectable RSFs using the BPASS population synthesis code, with different assumptions about the evolution of surface magnetic field strengths before merger. We find the rate of detectable RSFs to be ∼0.0001–5 per year for BHNS mergers and ∼0.0005–25 per year for NSNS mergers, with the lower bound corresponding to surface-field decay consistent with magneto-thermal evolution in purely crustal fields, while the upper bounds are for systems that have longer lived surface magnetic fields supported by flux frozen into the superconducting core. If some of the observed SGRB precursor flares are indeed RSFs, this suggests the presence of a longer lived surface field for some fraction of the NS population, and that we could expect RSFs to be the most common detectable EM counterpart to GW detections of BHNS mergers. The non-detection of an RSF prior to GRB170817A provides an upper bound on the magnetic fields of the progenitor NSs of Bsurf ∼ 1013.5G.