bluuebunny/crossref_metadata_2025_split huggingface dataset:
The missing piece in policy for carbon dioxide removal: reverse auctions as an interim solution
Authors: Lundberg Liv , Fridahl Mathias 
Published: April 2022

AbstractThe expectation that carbon dioxide removal (CDR) will play a crucial role in the climate transition is starting to gain traction in policy. An increasing number of countries are expanding their CDR policies, from specification of objectives (via elimination of regulatory obstacles) to market development. Among the many CDR options, sustainably sourced bioenergy with carbon capture and storage (BECCS) is often cited as having the greatest theoretical potential. Unlocking this potential will necessitate new and robust economic incentives. However, at present, there is a serious gap between actual policy and the required incentive structures, and developing these policies in a responsible way will likely take many years. To get BECCS started sooner than it otherwise might, we argue that an interim policy for allowing BECCS to mature would help identify potential trade-offs or pitfalls, and would help test how firms react to incentives for CDR before rolling our large scale international incentive structures. In this Perspectives article, we provide an insight into the current status of BECCS and CDR policy based on interviews with key policy makers and experts. We also provide a special insight into Sweden’s development of interim policy that takes the form of a reverse auction.
Compatibilist Libertarianism: Why It Talks Past the Traditional Free Will Problem and Determinism Is Still a Worry
Authors: WRIGHT JOHN DANIEL 
Published: April 2022

AbstractCompatibilist libertarianism claims that alternate possibilities for action at the agential level are consistent with determinism at the physical level. Unlike traditional compatibilism about alternate possibilities, involving conditional or dispositional accounts of the ability to act, compatibilist libertarianism offers us unqualified modalities at the agential level, consistent with physical determinism, a potentially big advance. However, I argue that the account runs up against two problems. Firstly, the way in which the agential modalities are generated talks past the worries of the incompatibilist in the traditional free will problem. As such, it fails to dispel the worries that determinism generates for the incompatibilist. Secondly, in spite of the ingenious use of the supervenience thesis and multiple realizability, the position still allows us to generate the old worry that determinism at the physical level would mean no alternate possibilities at the level of agency. In particular, I develop a new example, the ‘atomic slit case’ that demonstrates how physical level information is salient to what is possible at the agential level, motivating incompatibilism.
UNDECIDABILITY AND NON-AXIOMATIZABILITY OF MODAL MANY-VALUED LOGICS
Authors: VIDAL AMANDA 
Published: April 2022

AbstractIn this work we study the decidability of a class of global modal logics arising from Kripke frames evaluated over certain residuated lattices, known in the literature as modal many-valued logics. We exhibit a large family of these modal logics which are undecidable, in contrast with classical modal logic and propositional logics defined over the same classes of algebras. This family includes the global modal logics arising from Kripke frames evaluated over the standard Łukasiewicz and Product algebras. We later refine the previous result, and prove that global modal Łukasiewicz and Product logics are not even recursively axiomatizable. We conclude by closing negatively the open question of whether each global modal logic coincides with its local modal logic closed under the unrestricted necessitation rule.
‘Once a combatant, always a combatant’? Revisiting assumptions about Liberian former combatant networks
Authors: Käihkö Ilmari 
Published: April 2022

AbstractBuilding on 15 months of ethnographic fieldwork, this article draws from military sociology to revisit past portrayals of Liberian former combatant networks and assesses four central assumptions connected to them: that formal wartime command structures continue as informal networks long after the end of the war; that former combatants are united by a wartime identity and form a community to an extent separated from the surrounding society; that wartime experiences have had a major disciplining effect on former combatants; and that former combatants are both good mobilisers and easy to mobilise in elections and armed conflict alike. Finding limited evidence close to two decades after the end of war to support these assumptions, I ultimately ask whether it would be more productive to both theory and Liberians alike to widen investigation from former combatants to structural issues that affect many more in the country.
Changes in expeditioners' personality measures during 1 year Antarctic expeditions
Authors: Kokun Oleg , Bakhmutova Larysa 
Published: April 2022

AbstractThe extreme working and living conditions at Antarctic stations cause numerous psychological changes in expeditioners. However, research on the changes in expeditioners' personality traits is virtually non-existent. Therefore, the present study aims to determine the changes in expeditioners' personality measures during 1 year Antarctic expeditions. This study examined 56 expeditioners working at the Ukrainian Antarctic Akademik Vernadsky station (52 men, 4 women; ages 20–63 years, M = 38.12, SD = 10.01) who participated in five annual expeditions between 2016 and 2021. The Ukrainian adaptations of four measures were used: the Thomas-Kilmann Conflict Mode Instrument, the Eysenck Personality Questionnaire, the Leonhard-Schmieschek Questionnaire and the Leary Interpersonal Checklist. During 1 year Antarctic expeditions, 8 of the 26 indicators used to describe expeditioners' personality measures changed significantly (P < 0.001–0.1). These indicators belonged to three of the four measures used in the study and were assessed as personally unfavourable. They included increased psychoticism and competing, managerial-autocratic, aggressive-sadistic, responsible-hypernormal, competitive-narcissistic and self-effacing-masochistic styles and a decreased accommodating style. Based on these results, promising areas for further research that could improve psychological selection, training and work for Antarctic expedition personnel are outlined.
Earth System's Gatekeeping of “One Health” Approach to Manage Climate‐Sensitive Infectious Diseases
Authors: Dovie Delali B. K. , Miyittah Michael K. , Dodor Daniel E. , Dzodzomenyo Mawuli , Christian Aaron K. , Tete‐Larbi Reuben , Codjoe Samuel N. A. , Bawah Ayaga A. 
Published: April 2022

AbstractGlobal response to climate‐sensitive infectious diseases has been uncertain and slow. The understanding of the underlying vulnerabilities which forms part of changes created by forces within the Earth system has never before been critical until the coronavirus disease 2019, “COVID‐19” pandemic with the initial developmental phase linked to weather elements and climate change. Hence, the heightened interest in climate‐sensitive infectious diseases and GeoHealth, evident in the renewed calls for “One Health” approach to disease management. “One Health” explains the commonality of human and animal medicine, and links to the bio‐geophysical environment, yet are at crossroads with how forces within the Earth system shape etiologies, incidences, and transmission dynamics of infectious diseases. Hence, the paper explores how these forces, which are multistage and driven by climate change impacts on ecosystems affect emerging infectious diseases, leading to the question “what drive the drivers of diseases?” Three questions that challenge broad theories of Earth system science on boundaries and connectivity emerged to guide study designs to further interrogating disease surveillance and health early warning systems. This is because, climate change (a) drives prevailing biological health hazards as part of forces within the Earth system, (b) shifts disease control services of ecosystems and functioning to effectively regulate disease incidence, and (c) modifies pathogen—species hosts relationships. Hence, the need to rethink pluralistic concepts of climate‐sensitive diseases in their infection and management from a GeoHealth perspective, which “One Health” potentially conveys, and to also maintain ecosystem health.
Rock Magnetic Signatures of Hydrothermal Mineralization in the Trans‐Atlantic Geotraverse (TAG) Hydrothermal Field
Authors: Wang Shishun , Chang Liao 
Published: April 2022

AbstractThe Ocean Drilling Program Leg 158 drill holes from the Trans‐Atlantic Geotraverse hydrothermal field are investigated to understand the rock magnetic signatures of hydrothermal mineralization. A composite columnar section has been constructed through hole correlation to understand the stratigraphic variation of magnetomineralogy within the stockwork. Isothermal remanent magnetization components unmixing, first‐order reversal curve diagrams, low‐temperature magnetic signatures, and electron microscopic analyses disclose magnetic minerals of disparate occurrences related to predominating hydrothermal mineralization reactions in three broad zones: For basaltic basements, serpentinization of olivine phenocrysts during preliminary hydrothermal alteration produces magnetite, in addition to primary titanomagnetite; Chloritized and silicified zone samples contain relict titanomagnetite and exsolved magnetite that survived hydrothermal dissolution; Anhydrite and sulfide zone samples are dominated by magnetite and hematite, likely from oxidation of polymetallic sulfides due to exposure in oxidative seafloor environments during drilling. Our findings suggest that seafloor oxidation potentially modifies the magnetic properties of polymetallic sulfides in hydrothermal deposits, which applies to magnetic tomography of sophisticated subseafloor vent structures and prospecting seafloor massive sulfides (SMS) deposits therein. Meanwhile, we alert future deep‐sea mining that drilling may promote physicochemical alteration of SMS deposits, causing environmental risks. The established magnetic signatures ultimately contribute to understanding the in situ geological preservation of SMS deposits and optimizing exploitation procedures in the future.
In Situ and Orbital Stratigraphic Characterization of the InSight Landing Site—A Type Example of a Regolith‐Covered Lava Plain on Mars
Authors: Warner N. H. , Golombek M. P. , Ansan V. , Marteau E. , Williams N. , Grant J. A. , Hauber E. , Weitz C. , Wilson S. , Piqueux S. , Mueller N. , Grott M. , Spohn T. , Pan L. , Schmelzbach C. , Daubar I. J. , Garvin J. , Charalambous C. , Baker M. , Banks M. 
Published: April 2022

AbstractThe InSight lander rests on a regolith‐covered, Hesperian to Early Amazonian lava plain in Elysium Planitia within a ∼27‐m‐diameter, degraded impact crater called Homestead hollow. The km to cm‐scale stratigraphy beneath the lander is relevant to the mission's geophysical investigations. Geologic mapping and crater statistics indicate that ∼170 m of mostly Hesperian to Early Amazonian basaltic lavas are underlain by Noachian to Early Hesperian (∼3.6 Ga) materials of possible sedimentary origin. Up to ∼140 m of this volcanic resurfacing occurred in the Early Amazonian at 1.7 Ga, accounting for removal of craters ≤700 m in diameter. Seismic data however, suggest a clastic horizon that interrupts the volcanic sequence between depths of ∼30 and ∼75 m. Meter‐scale stratigraphy beneath the lander is constrained by local and regional regolith thickness estimates that indicate up to 10–30 m of coarse‐grained, brecciated regolith that fines upwards to a ∼3 m thick loosely‐consolidated, sand‐dominated unit. The maximum depth of Homestead hollow, at ∼3 m, indicates that the crater is entirely embedded in regolith. The hollow is filled by sand‐size eolian sediments, with contributions from sand to cobble‐size slope debris, and sand to cobble‐size ejecta. Lander‐based observations indicate that the fill at Homestead hollow contains a cohesive layer down to ∼10–20 cm depth that is visible in lander rocket‐excavated pits and the HP3 mole hole. The surface of the landing site is capped by a ∼1 to 2 cm‐thick loosely granular, sand‐sized layer with a microns‐thick surficial dust horizon.
Rural-urban difference in the prevalence of hypertension in West Africa: a systematic review and meta-analysis
Authors: Sani Ruqayya Nasir , Connelly Paul J. , Toft Mette , Rowa-Dewar Neneh , Delles Christian , Gasevic Danijela , Karaye Kamilu Musa 
Published: April 2022

AbstractUrbanisation is considered a major contributor to the rising prevalence of hypertension in West Africa, yet the evidence regarding rural-urban differences in the prevalence of hypertension in the region has been mixed. A systematic literature search of four electronic databases: PubMed, Embase, African Journals Online, and WHO’s African Index Medicus; and reference lists of eligible studies was carried out. Original quantitative studies describing the rural-urban difference in the prevalence of hypertension in one or more countries in West Africa, and published in English language from the year 2000 to 2021 were included. A random effects meta-analysis model was used to estimate the odds ratio of hypertension in rural compared to urban locations. A limited sex-based random effects meta-analysis was conducted with 16 studies that provided sex-disaggregated data. Of the 377 studies screened, 22 met the inclusion criteria (n = 62,907). The prevalence of hypertension was high in both rural, and urban areas, ranging from 9.7% to 60% in the rural areas with a pooled prevalence of 27.4%; and 15.5% to 59.2% in the urban areas with a pooled prevalence of 33.9%. The odd of hypertension were lower in rural compared to urban dwellers [OR 0.74, 95% CI: 0.66-0.83; p < 0.001]. The pooled prevalence of hypertension was 32.6% in males, and 30.0% in females, with no significant difference in the odds of hypertension between the sexes [OR 0.91, 95% CI: 0.8-1.05, p = 0.196]. Comprehensive hypertension control policies are needed for both rural, and urban areas in West Africa, and for both sexes.
Chip-integrated van der Waals PN heterojunction photodetector with low dark current and high responsivity
Authors: Tian Ruijuan , Gan Xuetao , Li Chen , Chen Xiaoqing , Hu Siqi , Gu Linpeng , Van Thourhout Dries , Castellanos-Gomez Andres , Sun Zhipei , Zhao Jianlin 
Published: April 2022

AbstractTwo-dimensional materials are attractive for constructing high-performance photonic chip-integrated photodetectors because of their remarkable electronic and optical properties and dangling-bond-free surfaces. However, the reported chip-integrated two-dimensional material photodetectors were mainly implemented with the configuration of metal-semiconductor-metal, suffering from high dark currents and low responsivities at high operation speed. Here, we report a van der Waals PN heterojunction photodetector, composed of p-type black phosphorous and n-type molybdenum telluride, integrated on a silicon nitride waveguide. The built-in electric field of the PN heterojunction significantly suppresses the dark current and improves the responsivity. Under a bias of 1 V pointing from n-type molybdenum telluride to p-type black phosphorous, the dark current is lower than 7 nA, which is more than two orders of magnitude lower than those reported in other waveguide-integrated black phosphorus photodetectors. An intrinsic responsivity up to 577 mA W−1 is obtained. Remarkably, the van der Waals PN heterojunction is tunable by the electrostatic doping to further engineer its rectification and improve the photodetection, enabling an increased responsivity of 709 mA W−1. Besides, the heterojunction photodetector exhibits a response bandwidth of ~1.0 GHz and a uniform photodetection over a wide spectral range, as experimentally measured from 1500 to 1630 nm. The demonstrated chip-integrated van der Waals PN heterojunction photodetector with low dark current, high responsivity and fast response has great potentials to develop high-performance on-chip photodetectors for various photonic integrated circuits based on silicon, lithium niobate, polymer, etc.
Influence of resistant starch resulting from the cooling of rice on postprandial glycemia in type 1 diabetes
Authors: Strozyk Sylwia , Rogowicz-Frontczak Anita , Pilacinski Stanislaw , LeThanh-Blicharz Joanna , Koperska Anna , Zozulinska-Ziolkiewicz Dorota 
Published: April 2022

AbstractIntroductionCarbohydrates are one of the macronutrients which have the most substantial influence on glycemic response. The cooling of rice after cooking causes retrogradation of starch, which becomes a non-absorbable product in the human digestive tract.Aim of the studyThis study aimed to assess whether cooling of rice affects postprandial glycemia in subjects with type 1 diabetes.Materials and methodsThe study included 32 patients with type 1 diabetes. Each participant of the study consumed two standardized test meals consisting of long-grain white rice. One of the test meals was served immediately after preparation, and another was cooled for 24 h at 4 °C after preparation and reheated before being served. Postprandial glycemia was measured for 3 h using the FreeStyle Libre flash glucose monitoring system for each patient.ResultsAfter consumption of the test meal containing rice subjected to the cooling process when compared to fresh rice, a significantly lower value of maximum glycemia (11 vs. 9.9 mmol/L,p = 0.0056), maximum glycemic increase (2.7 vs. 3.9 mmol/L,p < 0.0001), areas under the glycemic curve (135 vs. 336 mmol/L * 180 min,p < 0.0001) and significantly shorter time to peak (35 vs. 45 min,p = 0.031) was observed. There was a significantly higher number of hypoglycemic episodes among the patients after consuming test meals with cooled rice compared to fresh ones during 180 min of observation (12(38) vs. 3(9),p = 0.0039).ConclusionsConsumption of rice subjected to the cooling process results in a lower increase of postprandial blood glucose in subjects with type 1 diabetes. At the same time it increases the risk of postprandial hypoglycemia using a standard insulin dose.
Differential routing and disposition of the long-chain saturated fatty acid palmitate in rodent vs human beta-cells
Authors: Thomas Patricia , Arden Catherine , Corcoran Jenna , Hacker Christian , Welters Hannah J. , Morgan Noel G. 
Published: April 2022

Abstract
Background
Rodent and human β-cells are differentially susceptible to the “lipotoxic” effects of long-chain saturated fatty acids (LC-SFA) but the factors accounting for this are unclear. Here, we have studied the intracellular disposition of the LC-SFA palmitate in human vs rodent β–cells and present data that reveal new insights into the factors regulating β-cell lipotoxicity.

Methods
The subcellular distribution of the LC-SFA palmitate was studied in rodent (INS-1E and INS-1 823/13 cells) and human (EndoC-βH1) β-cells using confocal fluorescence and electron microscopy (EM). Protein expression was assessed by Western blotting and cell viability, by vital dye staining.

Results
Exposure of INS-1 cells to palmitate for 24 h led to loss of viability, whereas EndoC-βH1 cells remained viable even after 72 h of treatment with a high concentration (1 mM) of palmitate. Use of the fluorescent palmitate analogue BODIPY FL C16 revealed an early localisation of the LC-SFA to the Golgi apparatus in INS-1 cells and this correlated with distention of intracellular membranes, visualised under the EM. Despite this, the PERK-dependent ER stress pathway was not activated under these conditions. By contrast, BODIPY FL C16 did not accumulate in the Golgi apparatus in EndoC-βH1 cells but, rather, co-localised with the lipid droplet-associated protein, PLIN2, suggesting preferential routing into lipid droplets. When INS-1 cells were treated with a combination of palmitate plus oleate, the toxic effects of palmitate were attenuated and BODIPY FL C16 localised primarily with PLIN2 but not with a Golgi marker.

Conclusion
In rodent β-cells, palmitate accumulates in the Golgi apparatus at early time points whereas, in EndoC- βH1 cells, it is routed preferentially into lipid droplets. This may account for the differential sensitivity of rodent vs human β-cells to “lipotoxicity” since manoeuvres leading to the incorporation of palmitate into lipid droplets is associated with the maintenance of cell viability in both cell types.
Venetoclax combinations delay the time to deterioration of HRQoL in unfit patients with acute myeloid leukemia
Authors: Pratz Keith W. , Panayiotidis Panayiotis , Recher Christian , Wei Xudong , Jonas Brian A. , Montesinos Pau , Ivanov Vladimir , Schuh Andre C. , DiNardo Courtney D. , Novak Jan , Pejsa Vlatko , Stevens Don , Yeh Su-Peng , Kim Inho , Turgut Mehmet , Fracchiolla Nicola , Yamamoto Kazuhito , Ofran Yishai , Wei Andrew H. , Bui Cat N. , Benjamin Katy , Kamalakar Rajesh , Potluri Jalaja , Mendes Wellington , Devine Jacob , Fiedler Walter 
Published: April 2022

AbstractPhase 3 trials Viale-A and Viale-C evaluated health-related quality of life (HRQoL) in patients with AML unfit for intensive chemotherapy who received venetoclax (VEN) + (AZA) (Viale-A) or low-dose cytarabine (LDAC) (Viale-C) or placebo (PBO) + AZA or LDAC. Patient-reported outcomes included: EORTC QLQ-C30 global health status (GHS/QoL) and physical functioning (PF), PROMIS Cancer Fatigue Short Form 7a (Fatigue), and EQ-5D-5L health status visual analog scale (HS-VAS). Time to deterioration (TTD), defined as worsening from baseline in meaningful change thresholds (MCT) of ≥10, 5, or 7 points for GHS/QoL or PF, fatigue, and HS-VAS, respectively, was assessed; differences between groups were analyzed using Kaplan-Meier and unadjusted log-rank analyses. VEN + AZA vs PBO + AZA patients had longer TTD in GHS/QoL (P = 0.066) and fatigue (P = 0.189), and significantly longer TTD in PF (P = 0.028) and HS-VAS (P < 0.001). VEN + LDAC vs PBO + LDAC patients had significantly longer TTD in GHS/QoL (P = 0.011), PF (P = 0.020), and fatigue (P = 0.004), and a trend in HS-VAS (P = 0.057). Approximately 43%, 35%, 32%, and 18% of patients treated with VEN + AZA, AZA + PBO, VEN + LDAC, or LDAC + PBO, respectively, saw improvements >MCT in GHS/QoL. Overall, VEN may positively impact HRQoL in patients with AML ineligible for intensive chemotherapy, leading to longer preservation of functioning and overall health status.