bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single center retrospective subgroup analysis of “primary aortic” (aneurysm, aortic dissection, PAU) and “secondary aortic” (iatrogenic, trauma and aortoesophageal fistula) indications for emergency TEVAR
Authors: Rebelo Artur , Partsakhashvili Jumber , Ronellenfitsch Ulrich , John Endres , Kleeff Jörg , Ukkat Jörg 
Published: July 2022

Abstract
Background: The aim of the study was to analyse the outcome of emergency thoracic endovascular aortic repair (TEVAR) in the treatment of “primary aortic” (aneurysm, aortic dissection, penetrating aortic ulcer [PAU]) and “secondary aortic” (iatrogenic, trauma and aortoesophageal fistula) pathologies. Methods: Retrospective review of a cohort of patients treated at a single tertiary referral center from 2015 to 2021. Primary end point was postoperative in-hospital mortality. Secondary end points were the duration of the procedure, duration of postoperative intensive care treatment, length of hospital stay, and the nature and severity of postoperative complications according Dindo-Clavien Classification Results: A total of 34 patients underwent TEVAR for emergency indications. 22 patients were treated for primary and 12 patients for secondary aortic pathologies. Concerning in-hospital mortality, no statistically significant difference could be observed between the primary and secondary aortic groups (27.3% vs 33.3 %, p=0.711). Patients with aortoesophageal fistula had a mortality rate of 66.7%. Postoperative morbidity (Dindo-Clavien >3) was also not statistically significant different between the aortic and non-aortic groups (36.4% vs 33.3%, p=0.86). Preoperative hemoglobin level (mmol/L) (p<0.001), postoperative creatinine level (umol/L) (p=0.009) and pre- and postoperative lactate levels (p<0.001) were found to be independent factors associated with early mortality and morbidity (Dindo-Clavien >3). Conclusions: Morbidity and in-hospital mortality are still considerable after emergency TEVAR, for both aortic and non-aortic indications. Pre- and postoperative levels of hemoglobin, creatinine and lactate may be valuable to predict the patient outcomes.
A novel camptothecin derivative, ZBH-01, exhibits superior antitumor efficacy than irinotecan by regulating the cell cycle
Authors: Li Yongqi , Zhao Dawei , Zhang Wenqiu , Yang Miaomiao , Wu Zhihui , Shi Weiguo , Lan Shijie , Guo Zhen , Yu Hong , Wu Di 
Published: July 2022

Abstract
Irinotecan (CPT-11) is a classic chemotherapeutic agent that plays an important role in the clinical treatment of metastatic colon cancer and other malignant tumors. We previously designed a series of novel irinotecan derivatives and selected one representative, ZBH-01, to investigate its sophisticated antitumor mechanisms in colon tumor cells. Our current results showed that ZBH-01 has superior antitumor activity against colon cancer cells compared to CPT-11 and SN38 (7-Ethyl-10-hydroxy camptothecin), both in vivo and in vitro. However, its inhibitory ability on topoisomerase I (TOP1) was weaker than these two control drugs. Moreover, 842 mRNAs were downregulated and 927 were upregulated in the ZBH-01-treated group by Next-Generation Sequencing (NGS) and bioinformatics analysis. The most significantly enriched KEGG pathways for these dysregulated mRNAs were DNA replication, the p53 signaling pathway, and the cell cycle. Then, we constructed a protein-protein interaction (PPI) network and identified a significant cluster containing 73 genes, including 14 involved in the cell cycle process. ZBH-01 induced G0/G1 phase arrest and enhanced the levels of p53 protein in colon cancer cells, while CPT-11/SN38 caused S phase arrest. The initiation of apoptosis by ZBH-01 was also superior to CPT-11/SN38, followed by the increased expression of Bax, active caspase 3, and cleaved-PARP, and decreased expression of Bcl-2. Additionally, CCNA2 (cyclin A2), CDK2 (cyclin-dependent kinase 2), and MYBL2 (MYB proto-oncogene like 2) might be involved in the G0/G1 cell cycle arrest induced by ZBH-01. Overall, ZBH-01 can be an antitumor candidate drug for preclinical study in the future.
Effectiveness and Safety of Statins on Outcomes in Patients with HIV Infection: A Systematic Review and Meta-Analysis
Authors: Vigny Njeodo Njongang , Bonsu Kwadwo Osei , Kadirvelu Amudha 
Published: July 2022

Abstract
Statins are hypolipidaemic in human immunodeficiency virus (HIV) positive individuals. However, their all-cause mortality and discontinuation rates improvement is unclear. We evaluated statins impact on all-cause mortality, discontinuation rates, and adverse effects incidence among HIV patients on highly active antiretroviral therapy (HAART). We searched four electronic databases from inception until October 2021 for trials and cohort studies in HIV patients evaluating statins versus placebo. Forty-seven studies involving 91,594 patients were included. Statins significantly decreased discontinuation rates (RR, 0.701; 95% CI, 0.508–0.967; p = 0.031), but insignificantly reduced all-cause mortality (RR, 0.994; 95% CI, 0.561–1.588; p = 0.827). Also, statins insignificantly lowered the incidence of any adverse effects (RR, 0.780; 95% CI, 0.564–1.077; p = 0.131), diabetes mellitus (RR, 0.272; 95% CI, 0.031–2.393; p = 0.241) and raised the incidence of myalgia (RR, 1.341; 95% CI, 0.770–2.333; p = 0.299), and elevated creatine kinase (RR, 1.101; 95% CI, 0.457–2.651; p = 0.830) and liver enzyme (RR, 1.709; 95% CI, 0.605–4.831; p = 0.312) activities. In HAART-experienced patients, statins reduced discontinuation rates and had comparable effects on all-cause mortality with placebo. Furthermore, statin therapy did not increase the onset of any adverse effects, myalgia, elevated creatine kinase and liver enzyme activities, and decrease the onset of diabetes mellitus.
Optimized analysis of waveguides bends and Y-junctions with the Method of Lines
Authors: Spiller Waldemar 
Published: July 2022

Abstract
An analysis of bends and Y-junctions in different waveguide structures was described in the past using the Method of Lines. The impedance/admittance and field transformation were combined with finite differences. This paper will shown how waveguide bends and Y-junctions can be analyzed in an efficient way. The computation time is thus almost halved. It is also shown how different coordinate systems can be combined in the different sub-parts of the structures. For the demonstration, 2D defect waveguides in photonic crystals in the form of bends and Y-junctions are considered.
Accumulation of Heavy Metals and its Health Risk Assessment in Vegetables of India
Authors: Fazili Mohammad Afaan , Ahmad Naushad , War John Mohd , Nazir Romaan , Akram Mohammad 
Published: July 2022

Abstract
In the present study, the vegetable grown in different areas of Aligarh and sold in different places were studied for the extent of accumulation of eight selected heavy Metals. Samples of twenty selected vegetables were collected from three market sites of Aligarh city. The vegetables studied include different edible parts as root, stem, leaf, nascent inflorescence and fruit. The eight metals mainly cadmium (Cd), Chromium (Cr), Copper (Cu), Iron (Fe), Manganese (Mn), Nickel (Ni), Lead (Pb) and Zinc (Zn) have been determined in the edible parts and compared. The optimum Oral reference doses (RfD) mg kg-1 day-1 for heavy metals is (Cd =0.001), Chromium (Cr =1.5), Copper (Cu =0.04), Iron (Fe = 0.7), Manganese (Mn = 0.14), Nickel (Ni =0.02), Lead (Pb = 0.004) and Zinc (Zn =0.3) as per Indian standard.
Bioactivity of essential oils from Croton grewioides and its major compounds: toxicity to soybean looper Chrysodeixis includens and selectivity to the predatory stink bug Podisus nigrispinus
Authors: Santos Natielli Conceição , Silva Jefferson Elias da , Santos Ane Caroline Celestino , Dantas Jaciele de Oliveira , Tavares Swamy Rocha Siqueira Abreu , Andrade Valfran Silva , Oliveira Sara Dayan da Silva , Blank Arie Fitzgerald , Araújo Ana Paula Albano , Bacci Leandro 
Published: July 2022

Abstract
Natural biological control is a key factor that ensures the regulation of insect pest populations in agroecosystems. However, the indiscriminate use of pesticides has compromised this environmental service. Thus, the search for environmentally safe pesticides is an increasing requirement for sustainable food production. In this study, we analyzed the toxicity of essential oils from two accessions (CGR112 and CGR126) of Croton grewioides and its major compounds, methyl eugenol and eugenol, on the soybean pest Chrysodeixis includens. In addition, we investigated the sublethal effects of these compounds on the predatory bug Podisus nigrispinus, analyzing its developmental, reproduction and life table parameters. Essential oils and their major compounds were toxic to C. includens and P. nigrispinus. In general, the presence of eugenol made the essential oil more toxic to the pest and selective to the natural enemy. Eugenol was the most toxic compound for second instar larvae of C. includens at LD50, followed by CGR126 essential oil from C. grewioides which was equally toxic and this compound at higher doses. The estimated lethal times for essential oils to cause mortality in 50% of the population of C. includens were less than 15 hours. There was selectivity of the essential oil of CGR126 accession of C. grewioides at lethal doses above 90%. Although the treatments showed little effect on the development of P. nigrispinus, body mass and reproductive parameters were negatively affected, with the exception of the essential oil of CGR126 accession of C. grewioides. The essential oil of C. grewioides may represent a promising source to be used in the synthesis of new insecticides, which are efficient against C. includens and at the same time are safer for the natural enemy P. nigrispinus.
Paired Associative Transcranial Magnetic Stimulation Synchronized With Endogenous Human Hippocampus Activity Enhances Memorization Capacity
Authors: Agustín Arantzazu San , Crevillén David , Soto-León Vanesa , Moreno Juan C. , Oliviero Antonio , Pons Jose L. 
Published: July 2022

Abstract
The hippocampus is considered a fundamental cortical structure in the memory process of encoding, retaining, and recalling information. Transcranial Magnetic Stimulation (TMS) following a Paired Associative Stimulation (PAS) protocol is known to induce nervous system excitability enhancement and promote cortical plasticity mechanisms, synchronizing two stimuli in the same neural pathway. However, PAS has not been shown to improve memorization capacity yet. Here, we present an innovative PAS based on the paired application of single-pulse TMS towards the hippocampus synchronized with the endogenous hippocampal activity during a memory task. 96 volunteers were randomized across one experimental group and three parallel groups (motor cortex stimulation, sham stimulation and no stimulation) for a single PAS session. This new configuration of PAS resulted in an increased memorization capacity in the working memory task, dependent on the cortical location of the stimulation and subjects’ basal memory performance. Future research in PAS parameter variability would be required to unveil the PAS derived changes in neural mechanisms that enhance the ability to memorize. These results are potentially significant to clinical research on memory dysfunction and related neurological disorders.
UDP-glucose pyrophosphorylase as a target for regulating carbon flux distribution and antioxidant capacity in Phaeodactylum tricornutum
Authors: Zhang Ruihao , Zhu Baohua , Sun Changze , Li Yun , Yang Guanpin , Zhao Yan , Pan Kehou 
Published: July 2022

Abstract
UDP-glucose pyrophosphorylase (UGPase) is a key enzyme for polysaccharide synthesis, and its role in plants and bacteria is well established; however, its functions in unicellular microalgae remain ill-defined. Here, we performed bioinformatics as well as in vitro and in vivo analyses to elucidate the functions of two UGPs (UGP1 and UGP2) in the model microalga Phaeodactylum tricornutum. Despite differences in amino acid sequence, substrate specificity, and subcellular localization between UGP1 and UGP2, both enzymes could efficiently increase the production of chrysolaminarin (Chrl) or lipids by regulating carbon flux distribution without impairing growth and photosynthesis in transgenic strains. Productivity evaluation indicated that UGP1 played a bigger role in regulating Chrl and lipid production than UGP2. In addition, UGP1 enhanced antioxidant capacity, whereas UGP2 was involved in sulfoquinovosyldiacylglycerol (SQDG) synthesis in P. tricornutum. Taken together, the present results suggest that ideal microalgal strains can be developed for the industrial production of Chrl or lipids and lay the foundation for the development of methods to improve oxidative stress tolerance in diatoms.
Complication Rates in Concurrent Inflatable Penile Prosthesis and Incontinence Surgery: Comparing the Penoscrotal Versus Perineal Incision Approach
Authors: Blum Kyle , Mehr Justin , Green Travis , Macharia Kirema , Kim Daniel , Westney Ouida , Wang Run 
Published: July 2022

Abstract
Introduction: Limited data exist on inflatable penile prosthesis (IPP) complication rates following dual implantation with an artificial urinary sphincter (AUS) or bulbourethral male sling via a single perineal incision. Herein, we assess IPP complication rates after dual implantation via a single perineal incision versus more traditional penoscrotal approach. Methods: Patients with dual implantations of an IPP and AUS or sling between the 2011-2021 were identified. Postoperative IPP complications were assessed using the Clavien-Dindo (CD) classification at <30 days, 30 days–6 months, and >6 months. Treatment satisfaction was assessed using the validated EDITS questionnaire. IPP complication rates and mean EDITS scores were compared between the perineal and penoscrotal groups. Results: A total of 38 patients underwent dual implantation; 24 perineal vs 14 penoscrotal. There was no statistical difference in rate of complications between the two groups. The penoscrotal group had only two CD Grade I complications reported in the 30-day period and one Grade III complication in the >30 day to 6-month postoperative period. The perineal group had only two Grade III reported complications in the >6 month time frame. One patient in the perineal group and two in the penoscrotal group reported device malfunction at any point during follow-up, with no statistical difference in the rate of device malfunction. Conclusion: Patients undergoing dual IPP and AUS/sling placement via a perineal vs penoscrotal incision had similar IPP complication rates. A single perineal incision is a viable surgical approach for the dual implantation of an IPP and AUS or bulbourethral male sling.
Direct yield benefits of soil carbon increases in low-carbon soils: A global meta-analysis of cover cropping co-benefits
Authors: Vendig Isaac , Guzman Aidee , De Lacerda Gisel , Esqu Kenzo , Ponisio Lauren , Bowles Timothy 
Published: July 2022

Abstract
Cropland management practices that restore soil organic carbon (SOC) are increasingly presented as climate solutions that provide the additional benefit of yield enhancement. But how often these benefits align at the farm level — the scale of farmers’ decision-making — remains uncertain. We examined concurrent SOC and yield responses to cover cropping, including their direct connection, with a global meta-analysis. We showed that cover cropping simultaneously increased yields and SOC in 59.7% of 434 paired observations. Direct yield benefits from SOC enhancement were evident in soils with initial SOC concentrations below 9.2 g kg-1. These yield benefits did not vary with nitrogen inputs or cover crop type, suggesting they are not substitutable with fertilization. In all types of soils, the largest yield increases (up to +20.2%) coincided with the largest SOC increases (up to +16.8%) when legume cover crops were integrated into systems with simplified rotations or with nitrogen inputs < 136 kg N ha-1 season-1, thus providing substantial benefits for farmers and society regardless of direct effects of SOC on yield.
Letrozole, an anti-proliferative agent from Glycosmis pentaphylla (Retz.) DC. downregulates the expression of cyclin D1, PCNA and Bcl – xL in human neuroblastoma cell lines
Authors: Babu Vinitha S , B Surumi , Radhamany P M , Nair A Jayakumaran 
Published: July 2022

Abstract
BackgroundTo evaluate the effect of letrozole, an anti-proliferating agent from Glycosmis pentaphylla (Retz.) DC. on regulating the proliferation, cell cycle distribution, apoptosis and key mechanisms in human neuroblastoma cell lines.MethodsThe human neuroblastoma cell lines, IMR 32 were treated with different doses of letrozole. The effects of letrozole on cell viability were measured by MTT assay, and the cell cycle distribution was determined by flow cytometry. The expression change in mRNA of proliferating cell nuclear antigen (PCNA), cyclin D1 and Bcl-xL were taken from real-time PCR analysis and the protein levels were detected by Western blotting.ResultsThe results of the present study showed that letrozole could cause significant inhibitory effect on proliferation of IMR 32 cells in a dose dependent manner. Cell arrest was obtained at S phase with the treatment of letrozole. Apart from this, the expression of PCNA, cyclin D1 and Bcl-xL were decreased both at mRNA and protein levels for the same treatment.ConclusionLetrozole can inhibit proliferation, induce cell arrest and cause apoptosis in IMR 32 cell lines. The decreased expression of PCNA, cyclin D1 and Bcl-xL induced by letrozole contributes to the above effects in vitro.
The impact of Russian on GPS signal jamming in the Scandinavian Region
Authors: Pırtı Atınç , Yücel Mehmet Ali 
Published: July 2022

Abstract
GPS's dependability and precision are crucial because it supports infrastructure assets that are essential to the operation of the power grid, transportation, communication, and national and international financial operations. Worldwide productivity is rising thanks to GPS, which has also had a significant impact on military operations. Despite their significance, GPS signals are vulnerable to interference because of their relative weakness. This weakness gives terrorists and state actors that utilize GPS jamming devices a wide range of options. Although different types of jammers can cause varying degrees of interference, the use of powerful military jammers is becoming more and more common. The Russian military is deploying jammers to obstruct GPS satellite signals, which are essential for navigation, mapping, and other purposes. Considering that there are jammers in the region that prevent them from getting any usable signal, Scandinavian nations may not be able to use GPS on some days. In this study, how the jamming effect on the GPS satellites in the Scandinavian regions affects the position accuracy obtained and the performance of the GLONASS, Galileo, Beidou, and QZSS satellites that are used to eliminate this situation was investigated.
Spatial and temporal distribution of ApMV and ApNMV associated with mosaic disease of apple (Malus domestica) to optimize tissue and time for real time detection
Authors: Nabi Sajad Un , Mir Javid Iqbal , Din Ambreena , Raja Wasim H , Sharma Om Chand , Sheikh Muneer A 
Published: July 2022

Abstract
Background: Besides apple mosaic virus (ApMV), apple necrotic mosaic virus (ApNMV) has also been found associated with apple mosaic disease. Both viruses being labile in nature and their titer varies negatively with high temperatures, needs proper tissue as well as time for real time detection within the plants. The present study was carried out to understand the distribution and titre of ApMV and ApNMV in apple trees from different plant parts (spatial) during different seasons (temporal) for optimization of tissue and time for their timely detection.Methods and Results: The RT-PCR and RT-qPCR was carried out to detect and quantify both the viruses in various plant parts of apple trees during different seasons. Depending upon the availability of tissue, both ApMV and ApNMV were detected in all the plant parts during spring season using RT-PCR. During summer both the viruses were detected in only in seeds and fruits, whereas in leaves and pedicel during autumn season. The RT-qPCR results showed that during spring the ApMV and ApNMV expression was higher in leaves, where as in summer and autumn the titre was highest in seeds and leaves respectively. Conclusions: Leaves during spring and autumn, whereas seeds during summer season can be used as detection material via RT-PCR for early and rapid detection of ApMV and ApNMV. This study will help in accurate sampling to index the planting material well in time and will also aid in production of virus free planting material
Prevalence of Parenteral Nutrition-Associated Liver Disease in Neonates With Congenital Heart Disease
Authors: Santharam Yasasvhinie , Nitkin Christopher , Rajgarhia Ayan , Oschman Alexandra , Fischer Ryan , Feldman Keith 
Published: July 2022

Abstract
Objective: Infants receiving parenteral nutrition (PN) are at increased risk of PN associated liver disease (PNALD) which can manifest in hepatic fibrosis. While congenital heart disease (CHD) represents a risk factor for hepatic fibrosis, this study sought to better understand if infants with CHD were at elevated risk of PNALD when receiving long-term PN. Study Design: A retrospective cohort of infants at a Level-IV NICU 2010-2020 who received long-term PN during the first 8-weeks of life. A 5000-iteration bootstrap estimation for time-varying cox-survival model was used to model risk of PNALD adjusted for demographics and PN exposure. Results: Neonates with CHD were found to be at higher risk for PNALD during or quickly following long-term PN exposure. Conclusions: This work offers a step in understanding how diagnoses can be factored into neonate PN prescription. Future work will explore lipid profiles and timing to mitigate risk in patients with CHD.
Relationship between Sexual Quality of Life with Sexual Function and Sexual Distress in clinical married employed women
Authors: Arbabi Tahereh , Shahhosseini Zohreh , Ansari Fatemeh , Maasoumi Raziyeh , eslami Parisa , Hamzehgardeshi Zeinab 
Published: July 2022

Abstract
Objective: Sexual Quality Of Life (SQOL) is an important dimension of women's quality of life and several factors affect it. In this study, the relationship between SQOL with sexual function and sexual distress of clinical married employed women was investigatedMethods: The present study is a cross-sectional study that was performed on 385 clinical married employed women in hospitals of Tehran city Universities of Medical Sciences, using multi-stage sampling method during 2018. The research instruments include demographic information questionnaire, standardized Persian versions of female sexual function, female sexual distress scale, SQOL-F and Beck depression questionnaires and a researcher-made questionnaire of factors related to SQOL. The study data were analyzed using SPSS18 statistical software and the application of independent t-test, one-way ANOVA, chi-square and multiple linear regression.Results: 43.4% and 41.8% of the participants respectively had poor quality of sexual life and high sexual distress; While 64.7% of them had low sexual function. The variables of job type, education (postgraduate, bachelor’s and master’s degree) and domains of desire, satisfaction and pain in FSFI, total sexual function score and sexual distress score, were related factors to SQOL score.Conclusions: The majority of subjects in this study had good sexual quality of life but low sexual function, so the sexual quality of life in women can be affected by various factors (not just sexual function).