bluuebunny/crossref_metadata_2025_split huggingface dataset:
A hybrid Genetic–Grey Wolf Optimization algorithm for optimizing Takagi–Sugeno–Kang fuzzy systems
Authors: Elghamrawy Sally M. , Hassanien Aboul Ella 
Published: May 2022

AbstractNature-inspired optimization techniques have been applied in various fields of study to solve optimization problems. Since designing a Fuzzy System (FS) can be considered one of the most complex optimization problems, many meta-heuristic optimizations have been developed to design FS structures. This paper aims to design a Takagi–Sugeno–Kang fuzzy Systems (TSK-FS) structure by generating the required fuzzy rules and selecting the most influential parameters for these rules. In this context, a new hybrid nature-inspired algorithm is proposed, namely Genetic–Grey Wolf Optimization (GGWO) algorithm, to optimize TSK-FSs. In GGWO, a hybridization of the genetic algorithm (GA) and the grey wolf optimizer (GWO) is applied to overcome the premature convergence and poor solution exploitation of the standard GWO. Using genetic crossover and mutation operators accelerates the exploration process and efficiently reaches the best solution (rule generation) within a reasonable time. The proposed GGWO is tested on several benchmark functions compared with other nature-inspired optimization algorithms. The result of simulations applied to the fuzzy control of nonlinear plants shows the superiority of GGWO in designing TSK-FSs with high accuracy compared with different optimization algorithms in terms of Root Mean Squared Error (RMSE) and computational time.
Fist-Palm Test (FiPaT): a bedside motor tool to screen for global cognitive status
Authors: Cuoco Sofia , Erro Roberto , Carotenuto Immacolata , Picillo Marina , Pellecchia Maria Teresa , Barone Paolo 
Published: May 2022

Abstract

Objective
The Fist-Palm Test (FiPaT) is a novel non-verbal task to be used at the patient’s bedside for a cognitive functions screening. The aims of this study are to analyze (I) the qualitative and quantitative performance features at FiPaT, (II) the psychometric characteristics of FiPaT, and (III) the correlation between FiPat and traditional cognitive assessments in subjects with normal cognition (NC), Mild Cognitive Impairment-single domain (MCI-sd), and Mild Cognitive Impairment-multiple domain (MCI-md).

Methods
One hundred-thirteen subjects (53M/60F), with a mean age of 66.28 ± 7.22 years and 11.08 ± 4.93 years of education, were recruited and underwent a complete neuropsychological battery and FiPaT.

Results
We found 68 subjects with NC, 31 with MCI-sd, and 14 with MCI-md and a high reliability of the FiPaT (alpha =0.762). The number of FiPaT errors correlated with age and all neuropsychological tests, except for the memory recall test. Subjects with MCI had greater FiPaT errors than subjects with NC. The FiPaT, used with the MOCA test, predicted the presence of MCI, with a variance of 44%.

Conclusion
The FiPaT is an acceptable and reliable non-verbal test, able to screen for global cognitive status, attention, and executive functions, and to predict the MCI. Future studies will validate this initial findings as well as the discriminatory role of the FiPaT in detecting specific types of cognitive impairment.
The influence of UGT1A1 polymorphisms on modified FOLFIRINOX dose in double-variant-type patients with advanced pancreatic cancer
Authors: Satake Tomoyuki , Morizane Chigusa , Maruki Yuta , Ohba Akihiro , Nagashio Yoshikuni , Kondo Shunsuke , Hijioka Susumu , Ueno Hideki , Okusaka Takuji 
Published: May 2022

Abstract
Background
UGT1A1 polymorphisms should be considered when using irinotecan-containing regimens, especially in patients with a double-variant-type (DV), including homozygous for UGT1A1*28 and UGT1A1*6 and heterozygous for both UGT1A1*28 and UGT1A1*6. We investigated the safety and efficacy of modified FOLFIRINOX (mFOLFIRINOX) (irinotecan 80 mg/m2) in patients having DV.

Methods
Patients with advanced pancreatic cancer who had received FOLFIRINOX between January 2015 and December 2019 were included in this study. Non-DV patients received the standard mFOLFIRINOX (irinotecan 150 mg/m2) as first-line (non-DV1) or second-line therapy (non-DV2); however, DV patients received mFOLFIRINOX (irinotecan 80 mg/m2) as the second-line therapy (DV2). We retrospectively evaluated the safety and efficacy of the lowered irinotecan dose in the DV2 group relative to the non-DV1 (safety) or non-DV2 (safety and efficacy) groups.

Results
A total of 235 patients were eligible for this study with 118 patients in the non-DV1, 106 in the non-DV2, and 11 in the DV2 groups. Major grade 3–4 adverse events were neutropenia (33.9, 31.1, and 18.2%) and febrile neutropenia (6.8, 3.8, and 9.1%) in the non-DV1, non-DV2, and DV2 groups, respectively. The median progression-free survival was 3.4 months in the non-DV2 group, and 4.4 months in the DV2 group. The overall survival from the date of starting second-line chemotherapy was 8.8 months in the non-DV2 group and 11.5 months in the DV2 group.

Conclusions
Based on our findings, the safety and efficacy of mFOLFIRINOX (irinotecan 80 mg/m2) in DV patients were comparable with the standard mFOLFIRINOX (irinotecan 150 mg/m2) in non-DV patients.
Robotic oncologic colorectal surgery with a new robotic platform (CMR Versius): hope or hype? A preliminary experience from a full-robotic case-series
Authors: Huscher Cristiano , Marchegiani Francesco , Cobellis Francesco , Tejedor Patricia , Pastor Carlos , Lazzarin Gianni , Wheeler James , Di Saverio Salomone 
Published: May 2022

Abstract
Background
The present case-series describes the first full-robotic colorectal resections performed with the new CMR Versius platform (Cambridge Medical Robotics Surgical, 1 Evolution Business Park, Cambridge, United Kingdom) by an experienced robotic surgeon.

Methods
In a period between July 2020 and December 2020, patients aged 18 years or older, who were diagnosed with colorectal cancer and were fit for minimally invasive surgery, underwent robotic colorectal resection with CMR Versius robotic platform at “Casa di Cura Cobellis” in Vallo della Lucania,Salerno, Italy. Three right colectomies, 2 sigmoid colectomies and 1 anterior rectal resection were performed. All the procedures were planned as fully robotic. Surgical data were retrospectively reviewed from a prospectively collected database.

Results
Four patients were male and 2 patients were female with a median (range) age of 66 (47–72) years. One covering ileostomy was created. Full robotic splenic flexure mobilization was performed. No additional laparoscopic gestures or procedures were performed in this series except for clipping and stapling which were performed by the assistant surgeon due to the absence of robotic dedicated instruments. Two ileocolic anastomoses, planned as robotic-sewn, were performed extracorporeally. One Clavien–Dindo II complication occurred due to a postoperative blood transfusion. Median total operative time was 160 (145–294) min for right colectomies, 246 (191–300) min for sigmoid colectomies and 250 min for the anterior rectal resection.

Conclusions
The present series confirms the feasibility of full-robotic colorectal resections while highlighting the strengths and the limitations of the CMR Versius platform in colorectal surgery. New devices will need more clinical development to be comparable to the current standard.
Exploring the impact of spatial correlations of earthquake ground motions in the catastrophe modelling process: a case study for Italy
Authors: Schiappapietra E. , Stripajová S. , Pažák P. , Douglas J. , Trendafiloski G. 
Published: May 2022

AbstractCatastrophe models are important tools to provide proper assessment and financial management of earthquake-related emergencies, which still create the largest protection gap across all perils. Earthquake catastrophe models include three main components, namely: (1) the earthquake hazard model, (2) the exposure model and, (3) the vulnerability model. Simulating spatially distributed ground-motion fields within either deterministic or probabilistic seismic hazard assessments poses a major challenge when site-related financial protection products are required. In this framework, we develop ad hoc correlation models for different Italian regions (specifically northern, central and southern Italy) and thereafter we perform both deterministic scenario-based and probabilistic event-based hazard and risk assessments in order to advance the understanding of spatial correlations within the catastrophe modelling process. We employ the OpenQuake engine for our calculations. This is an open-source tool suitable for accounting for the spatial correlation of earthquake ground-motion residuals. Our outcomes, albeit preliminary, demonstrate the importance of considering not only the spatial correlation of ground motions, but also its associated uncertainty in risk analyses. Although loss exceedance probability curves for the return periods of interest for the (re)insurance industry show similar trends, both hazard and risk footprints in terms of average annual losses feature less noisy and more realistic patterns if spatial correlation is taken into account. Such results will have implications for (re)insurance companies evaluating the risk to high-value civil engineering infrastructures.
Commentary on Coram et al. (2021) on the use of Facebook to understand marine mammal stranding issues in Southeast Asia
Authors: Peter Cindy , Mustika Putu Liza Kusuma , Acebes Jo Marie Vera , Chansue Nantarika , Dolar Louella , Ham Gin Swen , Hines Ellen , Hte Wint , Minton Gianna , Ponnampalam Louisa Shobhini , Porter Lindsay , Vu Long , Westerlaken Rodney , Htay Yin Yin , Whitty Tara Sayuri 
Published: May 2022

AbstractWe reviewed Coram et al. (Biodivers Conserv 30:2341–2359, 2021, 10.1007/s10531-021-02196-6), a paper that highlights the use of social media data to understand marine litter and marine mammals in Southeast Asia. While we commend its intent, we find that the methodology used and conclusions drawn portray an incomplete and inaccurate perception of how strandings, stranding response, and analysis of stranding data have been conducted in the region. By focusing on investigative results revealed by a very limited search of one social media platform (Facebook), using only English keywords, and insufficient ground-truthing, Coram et al. (2021) have, unintentionally, given the perception that Southeast Asian scientists have not conducted even the bare minimum of investigation required to better understand the issue of marine litter and its impact on marine mammals. In this commentary we provide a more accurate account of strandings research in Asia and include recommendations to improve future studies using social media to assess conservation issues.
A Psychoeducational Support Group Intervention for People Who Have Attempted Suicide: An Open Trial with Promising Preliminary Findings
Authors: Maple Myfanwy , Wayland Sarah , Pearce Tania , Sanford Rebecca , Bhullar Navjot 
Published: May 2022

AbstractPsychoeducational groups have been used to address many health needs. Yet, there are few such options available for people who have attempted suicide. This study presents preliminary findings from an open trial of Eclipse, an 8-week closed, psychoeducational group for people who have attempted suicide. It examined the effectiveness of the Eclipse program in reducing suicidal ideation, depressive symptoms, perceived burdensomeness and thwarted belongingness, and increasing resilience and help-seeking. Results showed statistically significant improvements in depressive symptoms, perceived burdensomeness, resilience and help-seeking from baseline (T1) to immediate post-test (T2), and in perceived burdensomeness from T1 to 1-month follow-up (T3). A pervasiveness analysis showed that over half of the participants reported improvements in key study outcomes, respectively, as a result of participating in the Eclipse group. Psychoeducational support groups could provide broad application for those who have previously attempted suicide in decreasing severity of suicidal thinking by reductions in depressive symptoms, burdensomeness, and thwarted belongingness.
Targeting wild-type TP53 using AMG 232 in combination with MAPK inhibition in Metastatic Melanoma; a phase 1 study
Authors: Moschos Stergios J. , Sandhu Shahneen , Lewis Karl D. , Sullivan Ryan J. , Puzanov Igor , Johnson Douglas B. , Henary Haby A. , Wong Hansen , Upreti Vijay V. , Long Georgina V. , Flaherty Keith T. 
Published: May 2022

Abstract
Background
Targeting the MDM2-p53 interaction using AMG 232 is synergistic with MAPK inhibitors (MAPKi) in preclinical melanoma models. We postulated that AMG 232 plus MAPKi is safe and more effective than MAPKi alone in TP53-wild type, MAPKi-naïve metastatic melanoma.

Methods
Patients were treated with increasing (120 mg, 180 mg, 240 mg) oral doses of AMG 232 (seven-days-on, 15-days-off, 21-day cycle) plus dabrafenib (D) and trametinib (T) (Arm 1, BRAFV600-mutant) or T alone (Arm 2, BRAFV600-wild type). Patients were treated for seven days with AMG 232 alone before adding T±D. Safety and efficacy were assessed using CTCAE v4.0 and RECIST v1.1 criteria, respectively. Pharmacokinetic (PK) analysis was performed at baseline and steady-state levels for AMG 232.

Results
31 patients were enrolled. Ten and 21 patients were enrolled in Arm 1 and Arm 2, respectively. The most common AMG 232-related adverse events (AEs) were nausea (87%), diarrhea (77%), and fatigue (74%). Seven patients (23%) were withdrawn from the study due to AMG 232-related AEs. Three dose-limiting AEs occurred (Arm 1, 180 mg, nausea; Arm 2, 240 mg, grade 3 pulmonary embolism; Arm 2, 180 mg, grade 4 thrombocytopenia). AMG 232 PK exposures were not altered when AMG 232 was combined with T±D. Objective responses were seen in 8/10 (Arm 1) and 3/20 (Arm 2) evaluable patients. The median progression-free survival for Arm 1 and Arm 2 was 19.0 months-not reached and 2.8 months, respectively.

Conclusion
The maximum tolerated dose of AMG 232 for both arms was 120 mg. AMG 232 plus T±D exhibited a favorable PK profile. Although objective responses occurred in both arms, adding AMG 232 to T±D did not confer additional clinical benefit.
Experimental investigation of the near-surface flow dynamics in downburst-like impinging jets
Authors: Canepa Federico , Burlando Massimiliano , Romanic Djordje , Solari Giovanni , Hangan Horia 
Published: May 2022

Abstract
Downbursts are strong downdrafts that originate from thunderstorm clouds and create vigorous radial outflows upon hitting the ground. This study is part of the comprehensive experimental research on downburst outflows produced as large-scale impinging jets in the WindEEE Dome simulator at Western University, Canada. The 2800 tests carried out form the largest database of experimental measurements on downburst winds developed thus far, which is made available to the public in its whole and described in detail in a complementary study. Therefore, the current manuscript merely focuses on the data post-processing outcomes and interpretation of results from a selected subset of measurements. Impinging jets are here simulated as transient phenomena in which velocity time series are characterized by a sudden ramp-up of velocity, followed by the velocity peak, a short statistically stationary region, and the final velocity slowdown, as it is expected to occur in the actual downbursts. A dominant velocity peak that was systematically observed in all velocity records is associated with the radial advection of the primary vortex in the outflow. Depending on the radial distance from the downdraft, the primary vortex was sometimes preceded by a secondary, much smaller, vortex close to the surface. Vertical profiles of mean velocity and turbulence intensity are for the first time characterized through the extent of a downburst-like event in the spatiotemporal domain. Particularly, these profiles rapidly change in relation to the passage of the primary vortex and consequent variation of the surface layer thickness. This study lays out a foundation for an experimental model of non-stationary downburst outflows to come.
A conceptual model for unifying variability in space and time: Rationale, validation, and illustrative applications
Authors: Ananieva Sofia , Greiner Sandra , Kehrer Timo , Krüger Jacob , Kühn Thomas , Linsbauer Lukas , Grüner Sten , Koziolek Anne , Lönn Henrik , Ramesh S. , Reussner Ralf 
Published: May 2022

AbstractWith the increasing demand for customized systems and rapidly evolving technology, software engineering faces many challenges. A particular challenge is the development and maintenance of systems that are highly variable both in space (concurrent variations of the system at one point in time) and time (sequential variations of the system, due to its evolution). Recent research aims to address this challenge by managing variability in space and time simultaneously. However, this research originates from two different areas, software product line engineering and software configuration management, resulting in non-uniform terminologies and a varying understanding of concepts. These problems hamper the communication and understanding of involved concepts, as well as the development of techniques that unify variability in space and time. To tackle these problems, we performed an iterative, expert-driven analysis of existing tools from both research areas to derive a conceptual model that integrates and unifies concepts of both dimensions of variability. In this article, we first explain the construction process and present the resulting conceptual model. We validate the model and discuss its coverage and granularity with respect to established concepts of variability in space and time. Furthermore, we perform a formal concept analysis to discuss the commonalities and differences among the tools we considered. Finally, we show illustrative applications to explain how the conceptual model can be used in practice to derive conforming tools. The conceptual model unifies concepts and relations used in software product line engineering and software configuration management, provides a unified terminology and common ground for researchers and developers for comparing their works, clarifies communication, and prevents redundant developments.
Evolving software system families in space and time with feature revisions
Authors: Michelon Gabriela Karoline , Obermann David , Assunção Wesley K. G. , Linsbauer Lukas , Grünbacher Paul , Fischer Stefan , Lopez-Herrejon Roberto E. , Egyed Alexander 
Published: May 2022

AbstractSoftware companies commonly develop and maintain variants of systems, with different feature combinations for different customers. Thus, they must cope with variability in space. Software companies further must cope with variability in time, when updating system variants by revising existing software features. Inevitably, variants evolve orthogonally along these two dimensions, resulting in challenges for software maintenance. Our work addresses this challenge with ECSEST (Extraction and Composition for Systems Evolving in Space and Time), an approach for locating feature revisions and composing variants with different feature revisions. We evaluated ECSEST using feature revisions and variants from six highly configurable open source systems. To assess the correctness of our approach, we compared the artifacts of input variants with the artifacts from the corresponding composed variants based on the implementation of the extracted features. The extracted traces allowed composing variants with 99-100% precision, as well as with 97-99% average recall. Regarding the composition of variants with new configurations, our approach can combine different feature revisions with 99% precision and recall on average. Additionally, our approach retrieves hints when composing new configurations, which are useful to find artifacts that may have to be added or removed for completing a product. The hints help to understand possible feature interactions or dependencies. The average time to locate feature revisions ranged from 25 to 250 seconds, whereas the average time for composing a variant was 18 seconds. Therefore, our experiments demonstrate that ECSEST is feasible and effective.
A comprehensive overview of software product management challenges
Authors: Springer Olga , Miler Jakub 
Published: May 2022

AbstractThe principal focus of software product management is to ensure the economic success of the product, which means to prolong the product life as much as possible with modest expenditures to maximizs profits. Software product managers play an important role in the software development organization while being responsible for the strategy, business case, product roadmap, high-level requirements, product deployment (release-management), and retirement plan. This article explores the problems that affect the software product management process, their perceived frequency and perceived severity. The data were collected by a systematic literature review (5 main databases were analyzed), interviews (10 software product managers from IT companies), and surveys (89 participants). 95 software product management problems assigned nonexclusively to 7 areas were identified. 27 commonly mentioned software product management problems were evaluated for their perceived frequency and perceived severity. The problems perceived as the most frequent are: determining the true value of the product that the customer needs, strategy and priorities change frequently, technical debt, working in silos, and balancing between reactive and proactive work. In total, 95 problems have been identified which have been narrowed down to 27 problems based on their occurrence in at least 3 interviews. These selected problems were prioritized by perceived frequency and perceived severity. Some of the identified problems spanned beyond the software product management process itself, but they all affect the work of software product managers.
Newcomer OSS-Candidates: Characterizing Contributions of Novice Developers to GitHub
Authors: Rehman Ifraz , Wang Dong , Kula Raula Gaikovina , Ishio Takashi , Matsumoto Kenichi 
Published: May 2022

AbstractThe ability of an Open Source Software (OSS) project to attract, onboard, and retain any newcomer is vital to its livelihood. Although, evidence suggests an upsurge in novice developers joining social coding platforms (such as GitHub), the extent to which their activities result in a OSS contribution is unknown. Henceforth, we execute the protocols of a registered report to study activities of a “Newcomer OSS-Candidate”, who is a novice developer that is new to that social coding platform, and has the intention to later onboard an OSS project. Using GitHub as a case platform, we analyze 171 identified Newcomer OSS-Candidates to characterize their contribution activities. Results show that Newcomer OSS-Candidates are likely to target software based repositories (i.e., 66%), and their first contributions are mainly associated with development (commits) and maintenance (PRs). Newcomer OSS-Candidates are less likely to practice social coding, but eventually end up onboarding (i.e., 30% quantitative, 70% follow-up survey) an OSS project. Furthermore, they cite finding a way to start as the most challenging barrier to contribute. Our work reveals insights on how newcomers to social coding platforms are potential sources of OSS contributions.