bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression Of Inflammatory Markers In The Muscles Of Patients With Idiopathic Inflammatory Myopathy According To The Presence Of Interstitial Lung Disease
Authors: Lee Jung Sun , Ghang Byeongzu , Choi Wonho , Hong Seokchan , Kim Yong-Gil , Lee Chang-Keun , Nam Soo Jeong , Yoo Bin 
Published: February 2022

Abstract

Objective. Several studies have identified factors associated with the development of interstitial lung disease (ILD) in patients with idiopathic inflammatory myopathies (IIMs). However, few have assessed the association between ILD and muscle biopsy findings including inflammatory marker expressions analyzed using immunohistochemistry (IHC). We investigated the muscle biopsy findings that were associated with the presence of ILD.Methods. Muscle biopsies from patients who were newly diagnosed with IIMs between 2000 and 2017 were reviewed. ILD was diagnosed based on high-resolution computed tomography findings at the time of diagnosis of IIMs. IHC staining was performed for CD3, CD4, CD8, CD20, CD68, CD163, MX1, MHC class I, and HLA-DR. The factors associated with the presence of ILD were evaluated by logistic regression analysis. Results. Of the 129 patients with IIM, 49 (38%) had ILD. In muscle biopsy findings, CD4 expression (47% vs. 29%, P = 0.036), MX1 expression on immune cell (29% vs. 13%, P = 0.023), and expression of MHC class I (67% vs. 41%, P = 0.004) and HLA-DR (37% vs. 11%, P = 0.001) on myofiber were more common in patients with ILD than those without. In logistic regression analysis, HLA-DR expression on myofiber was significantly associated with the risk of ILD (OR, 2.39; 95% CI, 1.24–4.90, P = 0.012) after adjusting for pathologic findings, clinical features, and autoantibodies.Conclusion. Expression of HLA-DR on myofibers was associated with the presence of ILD in patients with IIM.
Enhanced Magneto-Optical Effect in Three Layer Based Magnetoplasmonic Structures
Authors: khaghani Zeinab , Farzad Mahmood Hosseini , Asgari Asghar 
Published: February 2022

Abstract
In this article we introduce a magnetoplasmonics (MP) planar nanostructure with enhanced transverse magneto-optical (MO) activity. For this goal MO characteristics of magneto-structures comprising both metal layer and linear array of (metal) nanorods are analyzed. We explore three types of structures with nanorods and compare their features based on transvers magneto-optical Kerr effect (TMOKE) with the corresponding one for conventional three layers MO structure. Comparison between the values of TMOKE signals in two structures (proposed and conventional) shows more than one order of magnitude improvement. Due to this feature the refractive index sensitivity of the offered structures, specially with one and three types of Au nanorod arrays, appearance more than 2 order of magnitude larger than the conventional Au/Co/Au three layer MO structures. This notable response enhancement becomes serious affair in MP biosensing applications. We believe that our idea in these proposed nanostructures can be used in any other three layer based MO structures in the literature. In this basis, we apply this scenario to other types of such MO structures which leads to improvement in their MO activities and accordingly in their refractive index sensitivities.
Single-axillary-incision Endoscopic Nipple/Skin-sparing Mastectomy With Immediate Implant-based Breast Reconstruction of Day Surgery: Preliminary Results, Complications and Patient-reported Outcome From Preliminary 68 Procedures
Authors: Feng Yu , Xie Yanyan , Zhou Jiao , Wen Nan , Qin Xiangquan , Liu Xinran , Li Juan , Yang Huanzuo , Qiu Mengxue , Liang Faqing , Du Zhenggui 
Published: February 2022

Abstract
Background and Aims The aim of this study is to present a day surgery protocol that minimizes resource utilization to enable hospitals to increase inpatient capacity and maximize treatment efficiency for breast cancer patients undergoing endoscopic nipple/skin-sparing mastectomy(E-N/SSM) with breast reconstruction through a single invisible axillary incision. Methods We retrospectively reviewed 60 consecutive patients(68 breasts) who underwent day surgery of E-N/SSM with implant-based reconstruction from July 2020 to November 2021 in West China Hospital. Postoperative complications, cost-effectiveness, and oncological safety were retrospectively analysed in patients. The SCAR-Q, BREAST-Q reconstruction module and photography were used to evaluate the breast satisfaction and quality of life(QoL). Results Sixty patients(68 breasts)with a mean age of 41.8±9.7 years were examined, with a median follow-up time of 6.5 months. Overall, the major complication rate and minor complication rate was 0% and 10.29%(7/68), respectively. Mean operation time was 123.94±24.26min(Surgeon A) and 180.64±16.68min (Surgeon B and C). The mean score of appearance scale of SCAR-Q was 60.9±12.7 at 3 months after operation. Breast satisfaction scores at 3 and 6 months after operation were significantly better than those before operation and at 1 month after operation (P<0.05); QoL scores (except for Physical Well-being: chest) at 6 months after operation were significantly better than those before operation(P<0.05). No local recurrence or distant metastasis developed. Conclusions Day surgery of E-N/SSM with immediate endoscopic breast reconstruction is safe and feasible in practice.
Phase Angle Research Study in NeoplastIc Patients Treated with Standard Chemotherapy (PARSNIP)
Authors: Vignini Arianna , Copparoni Cecilia , Pelati Elisa , Crocetti Sonia , Mobili Aurora Anna , Pistelli Mirco , Alia Sonila , Paolo Alice Di , Taus Marina , Berardi Rossana , Giampieri Riccardo 
Published: February 2022

Abstract
Purpose
This study evaluated whether a series of analyses that are associated with physical state decay, such as phase angle (PhA), obtained by bio-electrical impedance analysis (BIA) performed before the first cycle (t0) and after 1-2 months (t1) of chemotherapy, might be associated with differences in a series of clinical factors.
Methods
In this monocentric, prospective, observational study we enrolled patients affected by solid tumors (breast or gastrointestinal cancers) treated with chemotherapy at our Institution between February and July 2019. We calculated whether a series of clinical factors (age, sex, type of chemotherapy regimen, metastatic vs not-metastatic disease involvement and different tumor type) might be associated with changes in PhA. BIA analysis was performed with DF50 Body Composition Analyzer. Statistical analysis was performed with statistical software R (4.1.0) and MedCalc® Statistical Software version 19.7.2.
Results
Thirty patients were enrolled, treated with chemotherapy in neoadjuvant, adjuvant or first line metastastic setting. In the whole cohort of patients, it was observed a reduction of PhA (p=0.02) between t0 and t1. Stratifying by clinical variables, female patients (p=0.02), younger patients (p=0.02), predominantly with not-metastatic involvement (p=0.03), affected by breast cancer (p<0.01) and who received taxane-based chemotherapy (p=0.01) were those a statistically significant difference in PhA between t0 and t1 was observed.
Conclusion
Our study suggest that PhA decrease is frequent as neoplastic disease worsens. BIA is an effective method for detecting PhA that seems to be a good indicator of patient’s malnutrition state. Selected subgroups of patients might be at higher risk of PhA decrease (females, breast cancer patients, younger patients, those treated with taxanes) and should be offered prompt nutritional assessment and support. Further studies in these subgroups of patients are recommended.
State Estimation of Drive-by-wire Chassis Vehicle Based on Dual Unscented Particle Filter Algorithm
Authors: Wang Zixu , Chen Chaoning , Jiang Quan , Zheng Hongyu , Kaku Chuyo 
Published: February 2022

Abstract
Vehicle dynamic state parameter information plays an important role in vehicle driving safety, and accurate vehicle dynamic information can improve the dynamic performance of the controlled vehicle. This paper proposes a state estimation method for drive-by-wire chassis vehicle based on the dual unscented particle filter algorithm, which make full use of the known advantages of the four-wheel drive torque and steer angle parameters of the drive-by-wire chassis vehicle. In the dual unscented particle filter algorithm, two unscented particle filter transfer information to each other, observe the vehicle state information and the tire force parameter information of the four wheels respectively, which reduce the influence of parameter uncertainty and model parameter changes on the estimation accuracy during driving. Dual unscented particle filter algorithm is verified through both simulation and experiment. The performance with the proposed algorithm is analyzed in terms of the time-average square error in double lane change as compared to the case where unscented Kalman filter is utilized. The results demonstrate the effectiveness of the proposed algorithm.
Fine Unwrapping Phase for Deformation Control
Authors: omar Hadj Sahraoui 
Published: February 2022

Abstract
Earth observation and environmental control are becoming more important where the realization of DEM by the technique of interferometry of RSO images facilitates the control of terrestrial deformations, which is the subject of this paper. The unwrapping phase is a very important step in the interferometry process, especially to treat it carefully in steep degraded and mountainous ground. We have focused on the reduction and sometimes the elimination of the residues in flat terrains and otherwise to keep the maximum of the residues in the very steep sites. For this purpose, the methods developed and proposed are based on a transformation by the ISODATA which is based on KMEANS and the double passage of the median filter, and this in order to limit the creation of the brunch-Cut for the progress of the filtered interferogram (elimination of large black spot on The Brunch-Cut image).The tests of this method were carried out on several sites, and showed good results.
Tuneable Magnetic Nanocomposites for Remote Self-Healing
Authors: Gupta Ranjeetkumar , Gupta Priya , Footer Charles , Darr Jawwad , Pancholi Ketan , Stenning Gavin 
Published: February 2022

Abstract
When polymer composites containing magnetic nanoparticles (MNPs) are exposed to an alternating magnetic field, heat is generated to melt the surrounding polymer locally, partially filling voids across any cracks or deformities. Such materials are of interest for structural applications; however, structural polymers with high melting temperatures pose the challenge of generating high localised temperatures enabling self-healing. A method to prepare a multiferroic-Polyamide 6 (PA6) nanocomposite with tuneable magnetocaloric properties is reported. Tunability arises from varying the MNP material (and any coating, its dispersion, and agglomerate sizes in the nanocomposite). The superparamagnetic MNPs (SMNPs) and iron oxide MNPs with and without surface functionalization were dispersed into PA6 through in situ polymerization, and their magnetic properties were compared. Furthermore, computer simulations were used to quantify the dispersion state of MNPs and assess the influence of the interaction radius on the magnetic response of the self-healable magnetic nanoparticle polymer (SHMNP) composite. It was shown that maintaining the low interaction radius through the dispersion of the low coercivity MNPs could allow tuning of the bulk magnetocaloric properties of the resulting mesostructures. An in-situ polymerization method improved the dispersion and reduced the maximum interaction radius value from ca. 806 to 371 nm and increased the magnetic response for the silica-coated SMNP composite. This sample displayed ca. three orders of magnitude enhancement for magnetic saturation compared to the unfunctionalized Fe3O4 MNP composite.
Got Coke? Self-Limiting Poisoning Makes an Ultra Stable and Selective Sub-nano Cluster Catalyst.
Authors: Li Guangjing , Poths Patricia , Masubuchi Tsugunosuke , Morgan Harry , Alexandrova Anastassia , Anderson Scott L. 
Published: February 2022

Abstract
Supported sub-nano clusters hold great promise as economical and highly active catalysts. However, they tend to deactivate rapidly by poisoning and sintering, impeding their widespread use. We find that self-limiting poisoning can stabilize and promote cluster catalysis, i.e., poisoning is not always detrimental, but can sometimes be exploited. Specifically, Pt-Ge alloy clusters supported on alumina undergo slow coking (carbon deposition) under conditions of thermal dehydrogenation, yet preserve strong binding sites. For the case of Pt4Ge/alumina, theory shows a number of thermally populated isomers, one of which catalyzes carbon deposition. Because the clusters are fluxional at high temperatures, this isomer acts as a gateway, slowly converting all the clusters to Pt4GeC2. The surprising result is that Pt4GeC2 is highly catalytically active and selective against further coking, i.e., coking produces functional, stable catalytic clusters. Ge and C2 have synergistic electronic effects, leading to efficient and highly selective catalytic dehydrogenation that stops at alkenes, and improving stability. Thus, under reaction conditions, the clusters develop into a robust catalyst, suggesting an approach to practicable cluster catalysis.
Comprehensive Characterization and Screening of Different Trichoderma Isolates as Plant Growth Promoters: Insight to Metal Solubilization, Enzymatic Activity, and Antagonistic Effect
Authors: Hewedy Omar A. , Mansour Abdelaziz , Ali Mostafa G. , Lateif Khalid S. Abdel , Ismaiel Mohamed H. , El-Meihy Rasha M. 
Published: February 2022

Abstract
The present study aimed to isolate a Trichoderma species with dual action as a plant growth promoter in conjunction with antagonistic activity against the plant pathogen Colletotrichum lagenarium. Using internal transcribed spacer (ITS) sequences and inter simple sequence repeat markers (ISSR), eight strains of Trichoderma were identified, and their diversity was studied. In addition, some plant growth promoters such as indole acetic acid (IAA) and element solubilization were evaluated. Moreover, the activity of amylase, pectinase, cellulase, and chitinase was studied in the isolated species. Results showed that Trichoderma viride (T27) and Trichoderma atrobrunneum (T40) produced the highest IAA (80.36, 61.39 µg/mL), respectively and K solubilization efficiency (KE) (12.2 and 14.4, respectively). In contrast, Trichoderma afroharzianum (T31) and Trichoderma atrobrunneum (T40) had the highest zinc (Zn) solubilizer (7.1 and 7.2 cm), respectively. Strains T. viride (T27) and T. atrobrunneum (T41) showed the highest antagonistic activity against anthracnose fungi; therefore, they were examined under scanning electron microscopy. The SDS-PAGE protein pattern and its antigenicity analysis ranged between 40 and 180 kDa. The results of SDS-PAGE indicated that with chitin, both T27 and T40 presented different bands in their protein profile compared to the control (without chitin). The results suggest that T. viride (T27) and T. atrobrunneum (T40) could be used as eco-friendly bio-fungicides with a high potential plant growth promoter production.
The association between sleep duration and risk of abdominal obesity in Taiwanese adults: A cross-sectional study
Authors: Su Yan-Jhu , Lee Po-Fu , Lin Chi-Fang , Chen Yun-Tsung , Lo Kai-Yang , Chen Hui-Ling , Lin I-Tung , Ho Chien-Chang 
Published: February 2022

Abstract
Background: Previous studies examining the association of sleep duration with general obesity among adults are from western countries, where the patterns of adulthood sleep (shorter or longer sleep durations) and abdominal obesity may be different from Taiwan. Furthermore, the negative associations between sleep duration and abdominal obesity among adults in the existing literature remain controversial. The purpose of this study was to investigate the association between sleep duration and risk of abdominal obesity in Taiwanese adults.Methods: This was a cross-sectional study conducted on 58,238 adults who participated in Taiwan’s National Physical Fitness Survey 2014-2015. Data from a standardized structured questionnaire and anthropometric measures were analyzed. Individuals’ sleep durations were categorized as very short (≤5.0 h), short (5.1–6.0 h), optimal (6.1–7.0 h), long (7.1–8.0 h), or very long (>8.0 h). Abdominal obesity was classified according to waist circumference (WC) ≥ 90 cm for men and WC ≥ 80 cm for women. Multiple logistic regression analysis was performed to evaluate the risk factors for abdominal obesity.Results: The multiple logistic regression, using the optimal sleep duration as a baseline, indicated significant associations between very short (OR = 1.14, 95% CI: 1.02-1.27), short (OR = 1.11, 95% CI: 1.04-1.19) and very long (OR = 1.09, 95% CI: 1.02-1.18) sleep durations and abdominal obesity after adjusting for potential confounding factors.Conclusions: Our findings suggest that subjects with shorter or longer sleep durations have a much higher risk of abdominal obesity than those with optimal sleep durations. Shorter sleep durations may result in higher risk for abdominal obesity than longer sleep durations.
COVID-19 vaccine: factual reporting, dynamic preferences, and gender hesitancy
Authors: Rinaldi Anna , Dellino Pierfranceso 
Published: February 2022

Abstract
At different rates in different countries, one can observe the phenomenon of COVID-19 vaccine hesitancy. In June 2021, we surveyed 1,068 people in France and Italy to inquire about individual potential acceptance, focusing on time preferences, in a risk-return framework: getting the jab today, in a month, and in 3 months; perceived risks of vaccination and COVID-19; and expected benefit of the vaccine. We conducted a randomized controlled trial to understand the impact of daily stimuli, such as factual news about vaccines, on audience acceptance of vaccination. In the main experiment, participants were asked to read two different articles extracted from two Italian newspapers about vaccine-related thrombosis, one using a more abstract description and language and the other using a more anecdotical description and concrete language. We find that individual preferences for vaccination are variable and unstable over time, and individual choices of accepting, refusing, or delaying may be affected by the way news is written. To understand these dynamic preferences, we propose a new model based on seven categories of human behaviours that was validated by a neural network. We observe a treatment effect: participants who red the articles significantly shifted to vaccine hesitancy categories. Furthermore, we detect a peculiar gender effect, showing that the type of language that results in a higher vaccination rate for men is correlated with women’s lower vaccination rate and vice versa. This outcome should be taken into consideration for an appropriate gender-based communication campaign to achieve herd immunity.
Strengthening of Surface Urban Heat Island Effect Driven Primarily by Urban Size Under Rapid Urbanization: Empirical Evidence From China
Authors: Guo Yujie , Ren Zhibin , Dong Yulin , Hu Nanlin , Wang Chengcong , Zhang Peng , Jia Guangliang , He Xingyuan 
Published: February 2022

Abstract
Context
Surface urban heat islands (SUHIs) have received worldwide attention owing to their significant adverse impacts on socio-economic and environmental conditions. Although SUHI patterns have been studied previously, how the SUHIs change across cities with different sizes and whether there is a threshold of city size for affecting SUHIs remains poorly understood.
Objectives
The primary objective is to facilitate more appropriate and effective planning of SUHI mitigation in urbanized areas of different sizes.
Methods
The SUHI effects were deployed to surface urban heat island intensity (SUHII). we systematically analyzed the spatio-temporal patterns of SUHIs at the national scale under the conditions of China’s rapid urbanization, and explored the impact of natural and anthropogenic factors on SUHI by spatial error model.
Results
Intense urbanization occurred in China between 2000 and 2015, primarily dominated by the expansion of petty and mega urbanized areas. The SUHII gradually increased at the national scale from 2000–2015, and SUHIs also appeared in petty urbanized areas. We also found that the size of urbanized areas contributed the most to the increase in SUHII. In addition, the size of the urbanized areas had a positive non-linear relationship with SUHIIs, and when the size was larger than 400 km2, the growth of SUHIIs maintained an equilibrium state.
Conclusions
Urban expansion is occurring rapidly. This study highlights the importance of impervious surface expansion for increasing heat island intensity. To confront SUHI effects, it is necessary to reduce the fragmented distribution of small towns and increasing green infrastructures.
Self-sealing MEMS spray-nozzles to prevent bacterial contamination of portable inhalers for aqueous drug delivery
Authors: Last Torben Sebastian , Winkler Thomas E. , Stemme Göran , Roxhed Niclas 
Published: February 2022

Abstract
Pulmonary drug delivery by portable inhalers is the gold standard in lung disease therapy. An increasing focus on environmentally friendly inhalation currently spurs the development of propellant-free devices. However, the absence of propellants in the drug creates a need for suitable sealing systems that can ensure the pathogenic safety of devices. Traditionally, liquid drug inhalers incorporate a spray nozzle and a separate check valve. Here we show a fully integrated MEMS-based spray system for aqueous drug solutions and demonstrate its bacterial safety. The device comprises a thin silicon membrane with spray orifices, which self-seal against a compliant parylene valve seat underneath. This sealing system prevents bacterial ingrowth in its default closed state, while actuation lifts the membrane from the valve seat upon pressurization and sprays an inhalable aerosol from the nozzles. To seal against bacterial contamination effectively, we found that a contact force between the valve seat and the membrane (featuring the spray nozzles) is needed. In our testing, both self-sealing and an otherwise identical unvalved version of the spray chip can be bacterially safe in continued use when thoroughly cleaned of excess fluids and subjected to low bacterial loads for brief periods. However, when directly exposed