bluuebunny/crossref_metadata_2025_split huggingface dataset:
The interplay between forming planets and photoevaporating discs I: forbidden line diagnostics
Authors: Weber Michael L , Ercolano Barbara , Picogna Giovanni , Rab Christian 
Published: October 2022

ABSTRACT
Disc winds and planet formation are considered to be two of the most important mechanisms that drive the evolution and dispersal of protoplanetary discs and in turn define the environment in which planets form and evolve. While both have been studied extensively in the past, we combine them into one model by performing three-dimensional radiation-hydrodynamic simulations of giant planet hosting discs that are undergoing X-ray photoevaporation, with the goal to analyse the interactions between both mechanisms. In order to study the effect on observational diagnostics, we produce synthetic observations of commonly used wind-tracing forbidden emission lines with detailed radiative transfer and photoionization calculations. We find that a sufficiently massive giant planet carves a gap in the gas disc that is deep enough to affect the structure and kinematics of the pressure-driven photoevaporative wind significantly. This effect can be strong enough to be visible in the synthetic high-resolution observations of some of our wind diagnostic lines, such as the [O i] 6300 Å or [S ii] 6730 Å lines. When the disc is observed at inclinations around 40° and higher, the spectral line profiles may exhibit a peak in the redshifted part of the spectrum, which cannot easily be explained by simple wind models alone. Moreover, massive planets can induce asymmetric substructures within the disc and the photoevaporative wind, giving rise to temporal variations of the line profiles that can be strong enough to be observable on time-scales of less than a quarter of the planet’s orbital period.
Cosmological studies from HSC-SSP tomographic weak-lensing peak abundances
Authors: Liu Xiangkun , Yuan Shuo , Pan Chuzhong , Zhang Tianyu , Wang Qiao , Fan Zuhui 
Published: October 2022

ABSTRACT
We perform weak-lensing tomographic peak studies using the first year of shear data from the Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) survey. The effective area used in our analyses after field selection, masking, and boundary exclusions is $\sim 58 \deg ^2$. The source galaxies are divided into low- and high-redshift bins, with 0.2 ≤ zp ≤ 0.85 and 0.85 ≤ zp ≤ 1.5, respectively. We utilize our halo-based theoretical peak model, including the projection effect of large-scale structures, to derive cosmological constraints from the observed tomographic high-peak abundances with the signal-to-noise ratio in the range of νN = [3.5, 5.5]. These high peaks are closely associated with the lensing effects of massive clusters of galaxies. Thus, the inclusion of their member galaxies in the shear catalogue can lead to significant source clustering and dilute their lensing signals. We account for this systematic effect in our theoretical modelling. In addition, the impacts of baryonic effects, galaxy intrinsic alignments, as well as residual uncertainties in shear and photometric redshift calibrations are also analysed. Within the flat ΛCDM model, the derived constraint is $S_8=\sigma _8(\Omega _{\rm m}/0.3)^{0.5} =0.758_{-0.076}^{+0.033}$ and $0.768_{-0.057}^{+0.030}$ with the source clustering information measured from the two cluster catalogues CAMIRA and WZL, respectively. The asymmetric uncertainties are due to the different degeneracy direction of (Ωm, σ8) from high-peak abundances compared with that from the cosmic shear two-point correlations, which gives rise to the power index α ≈ 0.5. Fitting to our constraints, we obtain α ≈ 0.38 and $\Sigma _8=\sigma _8(\Omega _{\rm m}/0.3)^{\alpha }=0.772_{-0.032}^{+0.028}$ (CAMIRA) and $0.781_{-0.033}^{+0.028}$ (WZL). In comparison with the results from non-tomographic peak analyses, the 1σ uncertainties on Σ8 are reduced by a factor of ∼1.3.
Cosmology under the fractional calculus approach
Authors: García-Aspeitia Miguel A , Fernandez-Anaya Guillermo , Hernández-Almada A , Leon Genly , Magaña Juan 
Published: October 2022

ABSTRACT
Fractional cosmology modifies the standard derivative to Caputo’s fractional derivative of order μ, generating changes in General Relativity. Friedmann equations are modified, and the evolution of the species densities depends on μ and the age of the Universe tU. We estimate stringent constraints on μ using cosmic chronometers, Type Ia supernovae, and joint analysis. We obtain $\mu =2.839^{+0.117}_{-0.193}$ within the 1σ confidence level providing a non-standard cosmic acceleration at late times; consequently, the Universe would be older than the standard estimations. Additionally, we present a stability analysis for different μ values. This analysis identifies a late-time attractor corresponding to a power-law decelerated solution for μ &lt; 2. Moreover, a non-relativistic critical point exists for μ &gt; 1 and a sink for μ &gt; 2. This solution is a decelerated power law if 1 &lt; μ &lt; 2 and an accelerated power-law solution if μ &gt; 2, consistent with the mean values obtained from the observational analysis. Therefore, for both flat Friedmann–Lemaître–Robertson–Walker and Bianchi I metrics, the modified Friedmann equations provide a late cosmic acceleration under this paradigm without introducing a dark energy component. This approach could be a new path to tackling unsolved cosmological problems.
WHTZ 1: a high excitation Planetary Nebula not a gaseous cocoon from runaway star HD 185806
Authors: Parker Quentin A , Le Dû Pascal , Ritter Andreas , Goodhew Peter , Rasool Sakib , Charbonnel Stephane , Garde Olivier , Mulato Lionel , Petit Thomas 
Published: October 2022

ABSTRACT
We present evidence that the nebular cocoon and bow-shock emission nebula putatively and recently reported as deriving from the 9th magnitude ‘runaway’ star HD 185806 is the previously discovered but obscure Planetary Nebula WHTZ 1 (Ra 7). It has a Gaia DR3 G∼16 blue ionizing star at its geometric centre. We present imagery, spectroscopy, other data and arguments to support that this emission source is a high excitation Planetary Nebula not a stellar wind bow shock.
MicroCrystalline Tyrosine-adsorbed immunotherapy
Authors: Al Saleh Helal , Mösges Ralph 
Published: October 2022

Purpose of review
The purpose of this article is to provide an overview of the literature pertaining to the use of MicroCrystalline Tyrosine (MCT) in the immunotherapy with an emphasis on recent developments.

Recent findings
In addition to significant effectiveness and safety profiles, additional aspects of interest such as booster immunotherapy concepts, sustained clinical effects, long-term efficacy and disease-modifying effects are being focused on in the recently published studies. The depot adjuvant MCT also shows potential in promising disease-challenge models such as for malaria and melanoma.

Summary
MCT-adsorbed immunotherapy products have been shown to provide convincing overall safety, tolerability and efficacy outcomes, as well in vulnerable groups such as children and asthmatic patients.
Associations Between Inpatient Induction on Medications for Opioid Use Disorder and Postdischarge Medications for Opioid Use Disorder Adherence, Overdose, and Service Use
Authors: Noam Krista R. , Schmutte Timothy J. , Pirard Sandrine , Bourdon Carol , Langless Daniel , Plant Robert 
Published: October 2022

Objectives
This study aimed to examine outcomes of a pilot program designed to increase inpatient medications for opioid use disorder (MOUD) induction and to support MOUD adherence after discharge.

Methods
This retrospective cohort analysis examined Medicaid adults diagnosed with opioid use disorder discharged from 2 freestanding inpatient withdrawal management facilities between October 1, 2018, and December 31, 2019. Participants had ≥90 days of continuous Medicaid enrollment before and after admission. Odds ratios (ORs) examined associations of inpatient MOUD induction with discharge against medical advice, 7- and 30-day all-cause hospital readmission, and postdischarge MOUD adherence. Mixed-effect models examined changes associated with MOUD induction and postdischarge MOUD adherence in acute service utilization and opioid overdose in the 90-day postdischarge period.

Results
Of the 2332 patients discharged, 493 started MOUD inpatient care (21.1%), with most initiating buprenorphine (76.5%). Induction of MOUD was associated with a lower likelihood of discharge against medical advice (OR, 0.49; 95% confidence interval [CI], 0.37–0.64), 30-day all-cause hospital readmission (OR, 0.61; 95% CI, 0.47–0.80), and higher odds of postdischarge MOUD adherence (OR, 3.83; 95% CI, 3.06–4.81). In the 90 days after discharge, MOUD adherent patients had significant reductions in emergency department visits for behavioral health, inpatient days, withdrawal management episodes, and opioid overdoses compared with the 90-day preadmission period.

Conclusions
Inpatient MOUD induction is associated with a higher likelihood of short-term MOUD adherence after discharge, which in turn is associated with significant reductions in short-term service utilization and opioid overdose after discharge.
Pregnant and Postpartum Individuals' Knowledge, Attitudes, and Perceptions of Extended-release Buprenorphine for Treatment of Opioid Use Disorder
Authors: Lai Miao , Bowman Justin , Charles Jasmin , Smid Marcela C. 
Published: October 2022

Objective
The objective of this study is to explore pregnant and postpartum individuals' knowledge, attitudes, and perceptions regarding extended-release buprenorphine (XR-BUP) treatment for opioid use disorder.

Methods
We conducted a paper-based survey of pregnant or postpartum individuals with opioid use disorder attending a multidisciplinary perinatal addiction specialty care clinic where XR-BUP is available. Participants' nonidentifiable demographic and treatment characteristics were collected, including duration and satisfaction of current medication for opioid use disorder. Participants' knowledge, attitudes, and perceptions about XR-BUP were assessed using a 5-point Likert scale. Descriptive statistics were used to summarize the data.

Results
From February 2021 to August 2021, 79 of 98 eligible participants completed the survey (81% response rate). More than 9 of 10 participants were currently taking medication for opioid use disorder, and 7 individuals (8.9%) were taking XR-BUP. Nearly half (49.4%) had never heard of XR-BUP, and 84.8% did not personally know anyone taking XR-BUP. However, 45.6% and 29.1% would consider an injectable medication for opioid use disorder to avoid trouble remembering to take their daily medications and avoid opioid withdrawal symptoms, respectfully.

Conclusions
In a population of pregnant and postpartum individuals, nearly half were unaware of a monthly XR-BUP option for the treatment of opioid use disorder. Many were interested in considering this medication. Future studies are needed to rigorously assess outcomes associated with XR-BUP among pregnant and postpartum individuals with opioid use disorder.
Community Health Workers as Patient-Site Facilitators in Adult Hearing Aid Services via Synchronous Teleaudiology: Feasibility Results from the Conexiones Randomized Controlled Trial
Authors: Coco Laura , Carvajal Scott , Navarro Cecilia , Piper Rosie , Marrone Nicole 
Published: October 2022

Objectives:
The purpose of this study was to investigate the feasibility of Community Health Workers (CHWs) as patient-site facilitators in teleaudiology-facilitated hearing aid services to improve hearing aid rehabilitation outcomes for older Hispanic/Latino adults in a medically underserved, rural, US-Mexico border community.

Design:
A total of 28 adults (aged 55 to 89) with bilateral hearing loss participated in this study. Individuals were randomized to one of two teleaudiology intervention arms that differed at the level of the patient-site facilitator. Participants in the experimental group were assisted locally by trained CHW facilitators. Participants in the control group were assisted locally by trained university student facilitators. Synchronous (real-time) teleaudiology hearing aid services took place with participants located at a rural community health center and the clinician located a university 70 miles away. The results of this feasibility study are presented within the reach, effectiveness, adoption, implementation fidelity, and maintenance implementation framework.

Results:
Regarding reach, the participants in this study population are historically under-represented in research (primarily low-income Hispanic/Latino older adults). A total of 57 individuals were recruited, 47 were consented and assessed for eligibility and 28 individuals met inclusion criteria and were randomized. The average age of participants was 73.9 years, (range: 55 to 89 years) and most individuals were female (75%). Most participants (86%) reported having incomes less than $20,000 annually. Effectiveness results (via the Self Efficacy for Situational Communication Management Questionnaire) showed that both groups (CHW and control) significantly improved listening self-efficacy from pre-fitting baseline and no difference between groups was observed. Regarding datalogging, at the short-term follow-up, participants in the CHW group wore their hearing aids for more hours/day on average compared with participants in the control group. Implementation fidelity was high for both groups. Long-term maintenance of CHW-supported teleaudiology appears feasible given that training and institutional support is in place.

Conclusions:
Teleaudiology-delivered hearing aid services were feasible when facilitated locally by trained CHWs. Future efficacy and effectiveness research is warranted with CHWs and teleaudiology, potentially leading to a significant reduction in barriers for rural and medically under-resourced communities.
MRI-based Score for Assessment of Bone Mineral Density in Operative Spine Patients
Authors: Kim Ashley Yeo Eun , Lyons Keith , Sarmiento Manuel , Lafage Virginie , Iyer Sravisht 
Published: October 2022

Study Design.
Retrospective comparison.

Objective.
To determine whether a previously developed MRI-derived BMD scoring system can differentiate between healthy and osteoporotic vertebrae and to validate this scoring system against quantitative computed tomography measurements.

Summary of Background Data.
Bone mineral density is an important pre-operative consideration in spine surgery. Techniques to measure BMD are subject to falsely elevated values in the setting of spondylosis (DEXA) or require significant exposure to radiation (QCT). Previous studies have shown that MRI may be utilized to measure bone quality using changes in the bone marrow signal observed on T1-weighted MRIs.

Methods.
Retrospective study of patients who underwent operative lumbar procedures at a single tertiary institution between 2016 and 2021 (n=61). Vertebral bone quality (VBQ) scores were measured by dividing the median signal intensities of L1-L4 by the SI of CSF on noncontrast T1W MRI. Demographic data, comorbidities, VBQ scores, and QCT-derived T-scores and BMD of the lumbar spine were compared between healthy (T-score ≥−1; n=21), osteopenic (−2.5 < T-score < −1; n=21), and osteoporotic (T-score ≤−2.5; n=19) cohorts using ANOVA with post-hoc Tukey test. Linear regression and receiver operating characteristic curve analyses were performed to assess the predictive value of VBQ scores. Pearson correlation test was used to evaluate the association between VBQ scores and QCT-derived measurements.

Results.
VBQ differentiated between healthy and osteoporotic groups (P=0.009). ROC curve analysis revealed that a greater VBQ score was associated with presence of osteoporosis (AUC=0.754, P=0.006). Cutoff VBQ for osteoporosis was 2.6 (Youden index 0.484; sensitivity: 58%; specificity: 90%). VBQ scores weakly correlated with QCT-derived BMD (P=0.03, r=−0.27) and T-scores (P=0.04, r=−0.26).

Conclusion.
This study attempted to further validate a previously developed MRI-based BMD scoring system against QCT-derived measurements. VBQ score was found to be a significant predictor of osteoporosis and could differentiate between healthy and osteoporotic vertebrae.
Proton Pump Inhibitors and Cancer Risk
Authors: Zhang Man-Li , Fan Yu-Xin , Meng Rui , Cai Wen-Ke , Yin Sun-Jun , Zhou Tao , Huang Yan-Hua , Wang Ping , Jiang Fang-Fang , Yang Mei , He Gong-Hao 
Published: October 2022

Objectives:
Increasing evidence suggested that proton pump inhibitors (PPIs) use might affect the development of cancers, but previous conclusions remain controversial. Therefore, an umbrella review was performed to clarify the associations between PPIs and various types of cancer by summarizing the existing meta-analyses and systematic reviews.

Methods:
We searched PubMed, Cochrane Library, Embase, CNKI, Wanfang, and VIP database up to June 2022 for eligible meta-analyses or systematic reviews. The summary effect size, 95% CI, heterogeneity, small study effect, and 95% prediction interval were considered in the present study. A Measurement Tool to Assess Systematic Review 2 and grading of recommendation, assessment, development, and evaluation were used to assess methodological quality and evidence.

Results:
The umbrella review included 21 meta-analyses containing 65 studies and 10 cancer types with 6.8 million subjects. The results showed that PPI use was significantly associated with increased risks of certain types of cancer, including gastric cancer (odds ratio [OR]: 2.07; 95% CI, 1.30 to 3.29), pancreatic cancer (OR: 1.73; 95% CI, 1.23 to 2.44), colorectal cancer (OR: 1.84; 95% CI, 1.26 to 2.67), and liver cancer (OR: 1.80; 95% CI, 1.27 to 2.54), but was not associated with esophageal cancer. In addition, PPI use was associated with decreased risk of breast cancer (OR: 0.69; 95% CI, 0.50 to 0.96).

Conclusions:
These findings suggested that clinicians should pay more attention to the occurrence of gastric cancer, pancreatic cancer, colorectal cancer, and liver cancer in patients who used PPIs, and PPI prescription should be written only when an accurate specific diagnosis has been made. Furthermore, additional PPIs to the treatment regimen may be benefit for women with a higher-than-average risk of breast cancer.
Double-Scroll Formation by Fluid Column Manipulation in Preloaded DMEK Grafts Prepared From Younger and Older Donor Tissue
Authors: Straiko Megan M. W. , Odell Kelly , Blitzer Andrea L. , Tran Khoa D. , Veldman Peter B. 
Published: October 2022

Purpose:
The purpose of this study was to determine whether manipulation of preloaded single-scroll Descemet membrane endothelial keratoplasty (DMEK) grafts within the fluid column of an injector can safely and reliably result in formation of double-scroll DMEK grafts and whether there are differential effects on younger versus older donor tissue.

Methods:
Pairs of DMEK grafts prepared from older (65–80 years) and younger (48–64 years) donors were preloaded into a Straiko modified Jones tube. One member of the pair was manipulated within the fluid column to form a double-scroll graft, and the other remained unmanipulated. Outcomes measured include success rate for double-scroll formation, endothelial cell loss (ECL), and relative scroll width.

Results:
Older donor grafts formed double scrolls with a 100% success rate. ECL of older donor manipulated grafts was statistically higher than that of unmanipulated mate grafts (17.4% ± 3.5% vs. 13.0% ± 4.2%, P = 0.03), but was still within the acceptable range for transplant. Younger donor grafts were successfully manipulated into double scrolls with a 67% success rate, and there was no difference in the ECL of manipulated and unmanipulated grafts (15.5% ± 4.4% vs. 13.0% ± 4.5%, P = 0.24). For all grafts and conformations, there was a significant relationship between relative scroll width and ECL (P < 0.01).

Conclusions:
Fluid column manipulation can be used reliably to form double-scroll DMEK grafts. For younger donor grafts, manipulation yields a double scroll without increasing ECL. For older donor grafts, manipulation results in a minimal, acceptable increase in ECL. Surgeons should weigh the advantage of an easily opened graft against the risk of increased ECL when considering this technique.
Quantifying Clinicians’ Diagnostic Uncertainty When Making Initial Treatment Decisions for Microbial Keratitis
Authors: Hicks Patrice M. , Singh Karandeep , Prajna N. Venkatesh , Lu Ming-Chen , Niziol Leslie M. , Greenwald Miles F. , Verkade Angela , Amescua Guillermo , Farsiu Sina , Woodward Maria A. 
Published: October 2022

Purpose:
There is a need to understand physicians' diagnostic uncertainty in the initial management of microbial keratitis (MK). This study aimed to understand corneal specialists’ diagnostic uncertainty by establishing risk thresholds for treatment of MK that could be used to inform a decision curve analysis for prediction modeling.

Methods:
A cross-sectional survey of corneal specialists with at least 2 years clinical experience was conducted. Clinicians provided the percentage risk at which they would always or never treat MK types (bacterial, fungal, herpetic, and amoebic) based on initial ulcer sizes and locations (<2 mm2 central, <2 mm2 peripheral, and >8 mm2 central).

Results:
Seventy-two of 99 ophthalmologists participated who were 50% female with an average of 14.7 (SD = 10.1) years of experience, 60% in academic practices, and 38% outside the United States. Clinicians reported they would “never” and “always” treat a <2 mm2 central MK infection if the median risk was 0% and 20% for bacterial (interquartile range, IQR = 0–5 and 5–50), 4.5% and 27.5% for herpetic (IQR = 0–10 and 10–50), 5% and 50% for fungal (IQR = 0–10 and 20–75), and 5% and 50.5% for amoebic (IQR = 0–20 and 32–80), respectively. Mixed-effects models showed lower thresholds to treat larger and central infections (P < 0.001, respectively), and thresholds to always treat differed between MK types for the United States (P < 0.001) but not international clinicians.

Conclusions:
Risk thresholds to treat differed by practice locations and MK types, location, and size. Researchers can use these thresholds to understand when a clinician is uncertain and to create decision support tools to guide clinicians’ treatment decisions.
Variability in Serious Safety Event Classification among Children’s Hospitals: A Measure for Comparison?
Authors: Poppy Amy , Ziniel Sonja I , Hyman Daniel 
Published: October 2022

Introduction:
Hospitals have no standard for measuring comparative rates of serious safety events (SSE). A pediatric hospital safety collaborative has used a common definition and measurement system to classify SSE and calculate a serious safety event rate. An opportunity exists to evaluate the use of this measurement system.

Methods:
A web-based survey utilizing 7 case vignettes was sent to 132 network hospitals to assess agreement in classifying the vignettes as SSEs. Respondents classified the vignettes according to the taxonomy used at their respective organizations for deviations and SSE classification.

Results:
Of the 82 respondents, 67 (82%) utilized the same SSE classification system. Respondents did not assess deviations for 2 of the 7 vignettes, which had clear deviations. Of the remaining 5 vignettes, 3 had a substantial agreement of deviation (>85%, Gwet’s AC ≥ 0.68), and 2 had fair agreement (<70%, Gwet’s AC ≤ 0.39). Four of the 7 vignettes had a substantial agreement on SSE classification (>80%; Gwet’s AC ≥ 0.80), and 3 had slight to moderate agreement (<70%, Gwet’s AC ≤ 0.78).

Conclusions:
Results demonstrated agreement and variability in determining deviation and SSE classification in the 7 vignettes. Although the SSE methodology and metric used by participant pediatric hospitals yields generally similar review results, one must be cautious in using the SSE rate to compare patient safety outcomes across different hospitals.