bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inter/Transgenerational Effects of Drugs of Abuse: A Scoping Review
Authors: Zarrindast Mohammad-Reza , Sadat-Shirazi Mitra-Sadat , Sadeghi-Adl Mahsa , Akbarabadi Ardeshir , Ashabi Ghorbangol , Mokri Azarakhsh 
Published: May 2022

Abstract:
Drug addiction is a chronic relapsing disorder that makes it a global problem. Genetics and
environmental factors are the two most important factors that make someone vulnerable to drug addiction.
Investigations in the past decade highlighted the role of epigenetics in the inter/transgenerational
inheritance of drug addiction. A growing body of evidence showed that parental (paternal, maternal,
and biparental) drug exposure before conception changes the phenotype of the offspring, which is correlated
with neurochemical and neurostructural changes in the brain. The current paper reviews the effects
of parental (maternal, paternal, and biparental) exposure to drugs of abuse (opioids, cocaine, nicotine,
alcohol, and cannabis) before gestation in animal models.
Design and Molecular Docking Studies of N-Mannich Base Derivatives of
Primaquine Bearing Isatin on the Targets involved in the Pathophysiology
of Cerebral Malaria
Authors: Purohit Deepika , Dutt Rohit , Kumar Pawan , Kumar Sahil , Kumar Ajit 
Published: May 2022

Background::
Malaria is considered one of the life-threatening mosquito-borne infectious
diseases responsible for approximately more than 4,00,000 deaths every year all over the world. Plasmodium
falciparum and Plasmodium vivax are widespread species, but infections caused by the former
are of great concern.

Objective:
Among the various forms of infections associated with Plasmodium falciparum, cerebral
malaria (CM) is the most severe neurological complication, accounting for almost 13% of all malariarelated
mortality. The development of effective therapeutics is urgently needed to overcome the fatality
of this dreadful disease.

Methods:
The present work attempted to design and virtually screen a chemical library of 75 molecules
(N-Mannich base derivatives of primaquine bearing isatin moiety as heterocyclic) by molecular
docking studies against anti-malarial target proteins-Cystein Protease Falcipain-2; Dipeptidyl Aminopeptidase-
1; Dipeptidyl Aminopeptidase-3 and Glycogen synthase Kinase-3β receptors, for evaluating
their anti-malarial potential. Among all studied anti-malarial target receptors, the designed molecules
showed an overall higher affinity for Dipeptidyl Aminopeptidase-3. Furthermore, the molecules
were analyzed for binding affinity and drug-like properties using Lipinski rules, and 30 best hits were
shortlisted and analyzed for the pharmacokinetic profile.

Results:
Two of these hits were found to be more toxic than primaquine, hence were omitted in further
analysis. Later, these 28 hits were docked against two target proteins, (a) Plasmodium falciparum
erythrocyte membrane protein-1 and (b) Intracellular adhesion molecule-1, to determine their efficiency
against cerebral malaria, and the results were recorded. Analysis of docking results led to the identification
of the 8 studied molecules as lead molecules which were selected for chemical synthesis,
in vivo studies, and further preclinical evaluation.

Conclusion:
The molecule DSR 11 was predicted as the most appropriate lead molecule for anti-CM
activity in the present investigation apart from the other seven molecules (DSR4, DSR26, DSR38,
DSR40, DSR49, DSR56, and DSR70).
Microbiome and Development of Ovarian Cancer
Authors: Dhingra Aditi , Sharma Divyani , Kumar Anuj , Singh Shalini , Kumar Pramod 
Published: May 2022

Abstract:
Cancer of the female reproductive system involves abnormal cell growth that can potentially
invade the peritoneal cavity resulting in malignancy and disease severity. Ovarian cancer
is the most common type of gynecological cancer, which often remains undiagnosed until the
later stages of the disease or until cancer has metastasized towards the peritoneum and omentum,
compelling it to be a deadly disease complicating the prognosis and therapeutics. Environmental,
genetics and microbial factors are the common mainsprings to the disease. Moreover, human
beings harbor rich microbial diversity in various organs (gut, respiratory tract, reproductive tract,
etc.) as a microbiome, crucially impacting health. Any dysbiosis in the microbial diversity or
richness of the reproductive tract and gut can contribute to preconditions to develop/progress
various diseases, including ovarian carcinoma. The microbiome may have a casual or associate
role in ovarian cancer development, with Proteobacteria being the most dominant taxa in cancer
patients and Firmicutes being the most dominant in a normal healthy adult female. A healthy
estrogen-gut axis has an essential role in estrogen metabolism and utilization. However, estrobolome
(Bacteriodete, Firmicutes, Actinobacteria, and Proteobacteria) dysbiosis has an indirect
association with ovarian carcinoma. Microbes associated with sexually transmitted diseases also
impact the induction and progression of ovarian malignancies. Altogether, the microbes and their
metabolites are incidental to the risk of developing ovarian carcinoma.
Comparison of HPLC and ATR-FTIR Methods for the Determination of
Rosmarinic Acid in Aqueous Leaf Extract of Orthosiphon stamineus.
Authors: Akowuah Gabriel Akyirem , Chen Chow Jie 
Published: May 2022

Background:
Rosmarinic acid (RA) is an important natural bioactive compound widely distributed in food plants. ATR-FTIR and HPLC methods for comparative determination of RA in aqueous methanolic extracts of Orthosiphon stamineus leaf samples are described.

Method:
The quantitative determination of RA was performed by using HPLC with UV detection at 340 nm and ATR-FTIR based on peak height location at 1712.29 cm-1.

Results:
The mean recovery of RA was 99.54 ± 1.23% by the HPLC method and 105.48 ± 2.76 by the ATR-IR method. The relative standard deviation for the intra-day and inter-day precision were less than 5% for the HPLC method and less than 8% for the ATR-FTIR method. The limit of detection and limit of quantification values for the HPLC method were 2 ng/ml and 10 ng/ml, respectively. The limit of detection and limit of quantification values for the ATR-FTIR method were 0.14% and 0.83% w/w, respectively. The validated methods were used for the quantification of RA in leaf samples of O. staminues. The results of HPLC and ATR-FTIR methods were comparable.

Conclusion:
ATR-FTIR method is suitable for the routine determination of RA in herbal medicinal products of O. stamineus.
Exploring the Patent Landscape and Innovation of Hydrogel-based Bioinks
Used for 3D Bioprinting
Authors: Fatimi Ahmed 
Published: May 2022

Background:
This paper provides a comprehensive overview of the patent situation for hydrogel-
based bioinks used for 3D bioprinting globally. It encapsulates information which could be
used as a reference by researchers in the fields of 3D bioprinting, biomaterials, tissue engineering, and
biomedical engineering, as well as those interested in biomaterials, especially in the formulation of
hydrogels. It can also inform policy discussions, strategic research planning, or technology transfer in
this area. The findings presented hereinafter are considered novel research aspects regarding the used
hydrogels, their preparation methods, and their formulations, as well as the 3D bioprinting process using
hydrogels. Furthermore, the novel part, synthesized patents, is regarded as a breakthrough in hydrogel-
based bioinks.

Methods:
The following research aspects of this study are based on data collection from selected patent
databases. The search results are then analyzed according to publication years, classification, inventors,
applicants, and owners, as well as jurisdictions.

Results:
Based on the earliest priority date, it is possible to precisely assume that 2004 is considered
the starting year of patenting of hydrogel-based bioinks. Furthermore, 2020 was the year with the most
patent documents. According to the findings, the United States, China, and the Republic of Korea are
the most prolific countries in terms of patenting on hydrogel-based bioinks. The most prolific patenting
companies are from the United States, Sweden, and Australia, while universities from the Republic
of Korea and the United States are the academic institutions leading the way. Most inventions of hydrogel-
based bioinks intended for hydrogels or hydrocolloids used as materials for prostheses or for
coating prostheses are characterized by their function or physical properties.

Conclusion:
The state has been reviewed by introducing what has been patented concerning hydrogelbased
bioinks. Knowledge clusters and expert driving factors indicate that the research based on biomaterials,
tissue engineering, and biofabrication is concentrated in the most common patent documents.
Finally, this paper, which gives a competitive analysis of the past, present, and future trends in
hydrogel-based bioinks, leads to various recommendations that could help one to plan and innovate
research strategies.
UPAYA PERTAHANAN KEBERLANGSUNGAN INDUSTRI KERAJINAN ONIX DAN MARMER KABUPATEN TULUNGAGUNG
Authors: Aris Suseno Wahyu Rizki 
Published: May 2022

Abstrak: Penulisan artikel ini bertujuan untuk memberikan analisis mengenai upaya yang dilakukan oleh pelaku usaha kerajinan onix dan marmer dalam mempertahankan keberlangsungan industri yang dimilikinya meliputi pengembangan produk, pengembangan pasar, pengelolaan keuangan dan pendidikan ekonomi keluarga. Penulisan penelitian ini menggunakan pendekatan kualitatif serta jenis metode penelitian fenomenologi. Yang menjadi subyek adalah pelaku usaha kerajinan onix dan marmer di Kecamatan Campurdarat. Teknik yang digunakan adalah teknik pengambilan data berupa observasi, dokumentasi, wawancara mendalam serta triangulasi. Penelitian ini memperoleh hasil yaitu: (1) pengembangan produk yang digunakan yaitu dengan melakukan modifikasi produk yang sudah ada sebelumnya (2) Pengembangan pasar ini dilakukan dengan memasarkan produk yang sudah diproduksi tidak hanya melalui offline namun juga secara online, seperti media sosial maupun market place, (3) pengelolaan keuangan, sebagian pemilik industri sudah melakukan perencanaan dengan baik terhadap keuangan (4) Pendidikan ekonomi keluarga juga diterapkan oleh pemilik industri sebagai upaya untuk mempertahankan perusahaan yang mereka dirikan.Abstract: The writing of this article aims to provide an analysis of the efforts made by Onix and marble handicraft businesses in maintaining the sustainability of their industries including product development, market development, financial management, and family economic education. The writing of this research used a qualitative approach as well as a phenomenological research method. The subject is the handicraft and marble business actors in the Campurdarat District. The technique used is data collection techniques in the form of observation, documentation, interviews, and triangulation. This research obtained the results, namely: (1) product development used, namely by modifying existing products (2) Market development is carried out by marketing products that have been produced not only through offline but also online, such as social media and market places. (3) financial management, some industrial owners have planned well on finances. (4) Industry owners also apply for family economic education in an effort to maintain the companies they have founded.
Pengembangan perangkat pembelajaran statistika dan peluang untuk mengembangkan statistical literacy siswa SMP
Authors: Hariyanti Firda , Wutsqa Dhoriva Urwatul 
Published: May 2022

Penelitian ini bertujuan untuk (1) menghasilkan perangkat pembelajaran statistika dan peluang untuk mengembangkan statistical literacy siswa SMP yang valid, praktis dan efektif; dan (2) mendeskripsikan karakteristik perangkat pembelajaran statistika dan peluang untuk mengembangkan statistical literacy siswa SMP. Jenis penelitian ini adalah penelitian pengembangan. Pengembangan perangkat pembelajaran menggunakan model Plomp yang terdiri dari tiga tahapan, yaitu analisis, perancangan dan pengembangan prototipe, dan evaluasi. Instrumen penelitian terdiri dari lembar validasi, lembar keterbacaan, lembar penilaian guru, lembar penilaian siswa, lembar observasi keterlaksanaan pembelajaran, dan instrumen tes statistical literacy. Penelitian ini menghasilkan perangkat pembelajaran statistika dan peluang untuk mengembangkan statistical literacy siswa SMP yang terdiri dari RPP dan LKS yang telah memenuhi kriteria valid, praktis, dan efektif. Karakteristik dari hasil pengembangan perangkat pembelajaran statistika dan peluang untuk mengembangkan statistical literacy siswa SMP, yaitu (1) menggunakan model guided discovery learning; (2) adanya kegiatan yang membimbing siswa untuk menginterpretasikan, menyimpulkan, dan mengevaluasi data; dan (3) menggunakan masalah-masalah kontekstual terkait dengan pribadi, sekolah, dan masyarakat. AbstractThe objectives of this study were to (1) produce a statistics and probability teaching kit to develop statistical literacy of junior secondary school students that was valid, practical, and effective; and (2) describe the characteristics of statistics and probability teaching kit to develop statistical literacy of junior secondary school students. This study was research and development. The development of a teaching kit was using Plomp’s model consisting of three stages. Those were analysis, design and development of the prototype, and evaluation. The research instruments consisted of a validation sheet, legibility sheet, teacher's assessment sheet, student’s assessment sheet, learning enforcement observation sheet, and statistical literacy test instruments. This research produced statistics and probability teaching kit to develop statistical literacy of junior secondary school students consisting of a lesson plan and student’s worksheet which have met the criteria valid, practical, and effective. The characteristics of development result from statistics and probability teaching kit to develop statistical literacy of junior secondary school students were (1) using guided discovery learning model; (2) there were activities guide students to interpret, infer, and evaluate data; and (3) using contextual problems related to personal, school, and public
Intervention Mapping of a Gamified Therapy Prescription App for Children With Disabilities: User-Centered Design Approach
Authors: Johnson Rowan W , White Becky K , Gucciardi Daniel F , Gibson Noula , Williams Sian A 
Published: May 2022

Background
Mobile health (mHealth) apps for children are increasing in availability and scope. Therapy (physiotherapy, speech pathology, and occupational therapy) prescription apps to improve home or school program adherence work best when developed to be highly engaging for children and when they incorporate behavior change techniques (BCTs) within their design.

Objective
The aim of this study was to describe the development of a user-centered therapy prescription app for children (aged 6-12 years) with neurodevelopmental disabilities (eg, cerebral palsy, autism spectrum disorder, and intellectual disability) incorporating intervention mapping (IM) and gamified design.

Methods
We used an iterative, user-centered app development model incorporating the first 3 steps of IM. We conducted a needs analysis with user feedback from our previous mHealth app study, a literature review, and a market audit. Change objectives were then specified in alignment with the psychological needs of autonomy, competence, and relatedness identified in self-determination theory. From these objectives, we then selected BCTs, stipulating parameters for effectiveness and how each BCT would be operationalized. A gamification design was planned and implemented focusing on maximizing engagement in children. In total, 2 rounds of consultations with parents, teachers, and therapists and 1 round of prototype app testing with children were conducted to inform app development, with a final iteration developed for further testing.

Results
The IM process resulted in the specification of app elements, self-determination theory–informed BCTs, that were embedded into the app design. The gamification design yielded the selection of a digital pet avatar with a fantasy anime visual theme and multiple layers of incentives earned by completing prescribed therapy activities. Consultation groups with professionals working with children with disabilities (4 therapists and 3 teachers) and parents of children with disabilities (n=3) provided insights into the motivation of children and the pragmatics of implementing app-delivered therapy programs that informed the app development. User testing with children with disabilities (n=4) highlighted their enthusiasm for the app and the need for support in the initial phase of learning the app. App quality testing (Mobile Application Rating Scale-user version) with the children yielded means (out of 5) of 4.5 (SD 0.8) for engagement, 3.3 (SD 1.6) for function, 3.3 (SD 1.7) for aesthetics, and 4.3 (SD 1.1) for subjective quality.

Conclusions
mHealth apps designed for children can be greatly enhanced with a systematic yet flexible development process considering the specific contextual needs of the children with user-centered design, addressing the need for behavior change using the IM process, and maximizing engagement with gamification and strong visual design.
STUDY OF GENERALISED ANXIETY DISORDER AND FACTORS AFFECTING IT DURING POSTNATAL PERIOD.
Authors: Manish Tiwari  , Pise Harshal N , Mahima Tiwari  
Published: May 2022

ABSTRACT

Background: Anxiety disorders remain the commonest mental disorder in general population. Both these disorders are common in pregnant women and postpartum period and are underdiagnosed. There is a paucity of research on mental disorders and their risk factors among women during postnatal period in India. This study aims to estimate the incidence of generalised anxiety disorder (GAD) and depression and explore the common associated factors among postnatal women in India.
Aim: The present study aims to study the incidence and risk factors of generalised anxiety disorders among mothers attending the outpatient department clinic (OPD) for vaccination of their children or gynaecology OPD for follow up.
Methods: Total of 180 women of postpartum period, up to 6 months, was randomly selected and assessed using self-report questionnaire GAD-7 for GAD. General demographic details were obtained via a revalidated proforma. Incidence and risk factors for both these mental disorders were assessed.
Results: The incidence of GAD was found to be 31.11%. Primigravida mothers scored higher on GAD-7 score than multigravida mothers and incidence of GAD was also higher in primigravidas mothers (p=0.042). There was no significant association between age of mother, socioeconomic status of mother, and sex of the child born, with development of GAD in the postnatal period. Substance abuse in husband was significantly related to development of GAD in women in postnatal period.
Conclusion: A significant proportion of women had generalised anxiety disorder. Pregnancy for the first time was associated with increased risk of GAD. Substance abuse by husband is significantly associated with development of GAD and depression during postnatal period.
Farmers' Motivation in Implementing Jajar Legowo Planting System in Tegalsari, Kepanjen, Malang
Authors: Hamyana  , Khoirunisak  , Ugik Romadi  
Published: May 2022

This study aims at determining the factors affecting the farmers' motivation in implementing Jajar Legowo planting system. This study was conducted in Tegalsari, Kepanjen, Malang, from April to June, 2020. The population in this study was the members of farmer groups "Baru Muncul 1" and "Baru Muncul 2" totaling 152 people. Sampling technique employed was proportionate random sampling. The number of samples was determined by adopting Slovin formula at a degree of error of 10% as many as 60 respondents. Moreover, the data in this study were collected by employing a questionnaire. The method used for data analysis was multiple linear regression test with IBM SPSS 22 software. The results showed that internal factors (age, land area, education, length of farming) and external factors (availability of capital, intensity of extension, and availability of labor) affected farmers' motivation in implementing Jajar Legowo planting system by 65.6%, while the remaining 34.4% is affected by other variables which were unexamined in this study. The factors significantly affecting farmers' motivation in implementing Jajar Legowo planting system are internal factors (age, land area, education, length of stay), the availability of capital, the intensity of counseling, and the availability of labor.
The Economic Impact of Climate Change on the Local Apple
Authors: Ariadi Bambang Yudi 
Published: May 2022

An unavoidable climate change has an impact on agricultural production. This study aims at determining farmers’ knowledge concerning climate change and farmers’ behavior in apple cultivation, as well as it aims at investigating the impact of climate change on apple productivity, environmental damage, and apple prices. Primary data were collected using structured interviews to farmers of apple. Structural Equation Model (SEM) is employed to analyze the effect of climate change on production, environment and price changes. The results showed farmers possessed knowledge concerning climate change based on information mainly received from television and their perceived experience. Climate change causes the increase of warmer air temperatures, drought, and the need for product facilities, like fertilizers and pesticides. However, it causes the decrease of apple production. Climate change has a significant negative effect on apple productivity and the economic value of apples. The environment also has a negative effect on apple productivity at a lower level of significance. During climate change, apple productivity has a negative effect on apple prices, It means that the higher the apple productivity is, the lower the apple price will be. Hence, climate change caused the impact of a decrease in the economic value of local apple agribusiness in Malang Raya.
The Contagion Reputational Effects of Failed Individual Audit Partners: Evidence from an Audit Client Market
Authors: Gul Ferdinand A. , Lim Chee Yeow , Wang Kun , Xu Yanping 
Published: May 2022

SUMMARY
Prior research using individual auditor data shows that the stock market punishes the clients of failed auditors but not those of nonfailed auditors in the same tainted office (e.g., Li, Qi, Tian, and Zhang 2017). In this study, using audit client market share, we find similar results, but, more importantly, we document that the nonfailed partners’ client market shares decrease when they lack a track record to infer their audit quality credentials and when they reveal connections through teamwork experience with failed audit partners. In other words, nonfailed auditors in the same tainted office suffer contagion loss if there are no mitigating circumstances, such as a good track record or dissociation with failed auditors. These findings are novel in the literature and contribute to the empirical evidence for contagion effects in an individual partner reputational environment.
JEL Classifications: M41; M42; M48