bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cloud Failure Prediction based on Traditional Machine Learning and Deep Learning
Authors: Asmawi Tengku Nazmi Tengku , Ismail Azlan , Shen Jun 
Published: May 2022

Abstract
Cloud failure is one of the critical issues since it can cost millions to the cloud service providers in addition to the loss of productivity being suffered by the industrial users using different cloud-based applications and services. As the cloud system grows larger, the process of failure prediction is still a challenge for both practitioners and academic researchers. In this study, we tackle the challenge of predicting job and task failure using the benchmarking Google Cluster Traces Dataset. We first propose a conceptual model to prepare, construct and evaluate five traditional machine learning algorithms and three variants of the latest deep learning algorithms for predicting job and task failures. We then perform a series of experiments on two datasets; (1) Dataset A for the job failure prediction models and (2) Dataset B for the task failure prediction models. In the case of job failure prediction experiments, we observe that Extreme Gradient Boosting is the best performance with 94.35% accuracy with the F-Score score of 0.9310, 91.92% sensitivity, and 96.07% specificity. For Extreme Gradient Boosting, the disk space request and CPU request are the most important features in determining the outcome of the job prediction. In the case of task failure prediction, we observe that Decision Tree and Random Forest have achieved the highest 89.75% accuracy and 0.9145 for F-Score with 98% sensitivity and 78% specificity. The priority of the task is the most important feature for determining the task prediction outcome for both, the Decision Tree and Random Forest.
Bioinformatics identification of key genes associated with risk and prognosis of neuroblastoma
Authors: Zhang Jiao , Han Yahui , Yan Dun , Zhou Diming , Yuan Xiafei , Zhao Wei , Zhang Da 
Published: May 2022

Abstract
Objective
Neuroblastoma is a childhood malignancy with high morbidity and mortality. Through bioinformatics analysis, we identified key biomarkers associated with neuroblastoma risk and prognosis.
Methods
The gene modules most associated with neuroblastoma risk were derived by weighted gene co-expression network analysis (WGCNA). Modular genes were intersected with differentially expressed genes (DEGs) between high-risk neuroblastoma (HR-NB) patients and non-high-risk neuroblastoma (NHR-NB) patients to obtain risk genes, and enrichment analysis was performed. After incorporating risk genes into Cox regression analysis, Least Absolute Shrinkage and Selector Operation (LASSO) algorithm, and Kaplan-Meier survival analysis, key genes were identified and introduced into three external datasets for validation. In addition, we performed short time-series expression miner (STEM) analysis and single sample genome enrichment analysis (ssGSEA). Finally, we evaluated the difference in DNA methylation levels to identify meaningful methylation marks.
Results
The 26 risk genes we screened were mainly associated with ion channels and ion transport across membranes. We identified 5 key genes (ANO6, CPNE2, DST, PLXNC1, SCN3A) for neuroblastoma risk and prognosis, which correlated closely with known neuroblastoma biomarkers. All key genes showed a progressive down-regulation trend with increasing risk levels of neuroblastoma. The level of immune infiltration of 14 immune cells was significantly different between HR-NB and NHR-NB, and most immune cells were negatively correlated with key genes. Furthermore, the expression of ANO6, CPNE2, DST and PLXNC1 was modified by DNA methylation.
Conclusion
This study identified 5 key genes for neuroblastoma risk and prognosis that were potential biomarkers and potential therapeutic targets for neuroblastoma.
Does Nail Size or Difference between Canal and Nail Diameter Influence Likelihood of Union or Time to Union of Femoral Shaft Fractures Treated With Intramedullary Nailing? A retrospective cohort study
Authors: Shih Chiu-Yu , Lo Yu-Cheng , Hsu Chiu-Ting 
Published: May 2022

Abstract
BackgroundThis study aims to determine whether nail size or the difference between canal and nail diameter (CN difference) affects the union rate and time of femoral shaft fracture treated with an interlocking intramedullary nail (IMN).MethodsThis was a retrospective review of 257 patients with femoral shaft fractures treated with IMN at a tertiary trauma medical center. All the IMN inserted were the same (Stryker T2 Femoral Nail). The patients were divided into groups based on nail size (10-, 11-, 12-, or 13-mm) and CN difference (<1, 1-2, or >2 mm), and union rate and time to union were compared.ResultsThe 10-, 11-, 12-, and 13-mm groups based on nail size had 113, 74, 54, and 16 patients, respectively. The overall union rate was 97% (256/264). No significant differences in union rate or time to union were observed among these 4 groups. The groups based on CN differences of <1-, 1 to 2, and >2 mm comprised 143, 79, and 35 patients, respectively. Again, no significant differences were noted in union rate or mean time to union among the groups.ConclusionsSimilar union rate and time to union were observed, regardless of nail size or CN difference. This finding indicates that most simple femoral shaft fractures can be treated with a standard, reamed 10-mm IMN. A larger nail insertion is unnecessary and presents more risks; comparatively, the use of a small nail with less reaming is simpler, requires shorter operative times, results in less blood loss, and is less expensive.
Impaired mitochondria of Tregs decreases OXPHOS-derived ATP in primary immune thrombocytopenia with positive plasma pathogens detected by metagenomic sequencing
Authors: Zhan Yanxia , Ji Lili , Qian Mengjia , Zhang Miaomiao , Shen Qi , Xu Pengcheng , Zhuang Xibing , Qin Sansan , Hua Fanli , Sun Lihua , Li Feng , Chen Hao , Cheng Yunfeng 
Published: May 2022

Abstract
Background Primary immune thrombocytopenia (ITP) is an autoimmune disease. Some of patients are associated with pathogen infections undetected with conventional technologies. Investigating the changes of T cells and potential metabolic mechanism are important for better understanding of ITP. Methods Seventy-five newly diagnosed ITP patients were enrolled in the study. The pathogens of ITP patients were detected by metagenomic next-generation sequencing (mNGS). CD4+ T cell subsets and CD8+ T cells were analyzed using flow cytometry. Mitochondrial reactive oxygen species (ROS) and mitochondrial membrane potential were measured by flow cytometry. Seahorse XF real-time ATP rate assay was used to investigate the change of cellular metabolism.Result Positive plasma pathogens were detected in 7 ITP patients. Of them, 5 (71.4%) positive pathogen-ITP patients were NR after first-line treatment with corticosteroids. Tregs increased significantly in positive pathogen-ITP patients compared to negative pathogen-ITP patients and HC. Mitochondrial membrane potential of Th17 and Tregs were decreased in positive pathogen-ITP and negative pathogen-ITP patients, compared to HC (p<0.05). The overall metabolism flux of positive pathogen-ITP patients was decreased, as compared to HC (p=0.004), of them a higher proportion of glycolysis-derived ATP and a smaller proportion of oxidative phosphorylation (OXPHOS)-derived ATP were found in Tregs. The ATP rate index of Tregs was decreased significantly in positive pathogen-ITP patients compared to negative pathogen-ITP patients and HC.Conclusion Impaired mitochondria function of Tregs in positive pathogen-ITP patients caused a decrease of OXPHOS-derived ATP and overall metabolism flux that might be the cause of steroid resistance in ITP patients.
Comprehensive effects of different chemical preservatives on dehydrated diced radish during storage
Authors: Muratkhan Marat , Sugyrbai Adilet , Gulnazym Ospankulova , Mutamed Awais 
Published: May 2022

Abstract
This study aimed to the effect of chemical preservatives on dehydrated diced radish, as well as their effect on the taste, nutritional value and shelf life of the final product. Before dehydration turnip diced were treated with different chemical preservatives and their different concentrations viz. The eight samples were added T1 = 0.1% potassium metabisulphite, T2 = 0.1% sodium benzoate, T3 = 0.1% potassium sorbate, T4 = 0.05% potassium metabisulphite + 0.05% sodium benzoate, T5 = 0.05% potassium metabisulphite + 0.05% potassium sorbate, T6 = 0.05% sodium benzoate + 0.05% potassium sorbateT7 = 0.05% potassium metabisulphite + 0.025% sodium Benzoate + 0.025% potassium sorbate, T0 = no chemical preservative. Samples were evaluated for physiochemical (moisture, pH, total solid, titratable acidity, ash and ascorbic acid), sensory (color, texture, taste and overall acceptability) and total bacterial count at 15 days interval of 90 days storage. Moisture value was decreased during storage. Maximum decreased was found in T0 (8.65) 3.52% while minimum decrease was observed in T1 (9.23)1.40%. pH was decreased during storage. The maximum decrease was observed in T0 (5.44) 16.10%. While minimum decreased found in T1 (5.64) 6.36%. Titratable acidity value was increased during storage. Maximum increase was observed in T0 (1.96) 17.78% while minimum increase was observed in T1 (1.81) 8.05%. Total solid was increased during storage. Maximum increase was found in T0 (91.35) 0.34% and lower limit was detected in T1 (90.77) 0.14%. Ash content was increased with storage interval. Maximum increased in T0 (6.57) 2.31% while minimum in T1 (6.08) 0.99%. Ascorbic acid was decreased during storage. Maximum decreased in T0 (6.15)80.48% while minimum in T1 (9.05) 37.79%. Color, Texture, Taste and Overall acceptability were decreased with storage interval. Color maximum score was found in T1 (7.70) while minimum score was found in T0 (3.97). Texture maximum score was found in T1 (8.06) and minimum score in T0 (2.97). Taste maximum score was found in T1 (7.56) while minimum was noticed in T0 (3.33). Maximum score of overall acceptability was found in T1 (7.77) while minimum score obtained by T0 (3.42). Total bacterial count was increased with storage interval. Maximum increased in T0 (24.43x107) 800% while minimum increased in T1 (10.57x107cfu/g) 375%. Both chemical preservatives and storage intervals resulted in highly significant (p < 0.000) differences for all parameters. When comparing the chemical preservatives, the best acceptability among all the treatments was obtained by T1 which was treated with 0.1% potassium metabisulphite.
Bradykinin and Galectin-3 in Survived and Died Patients With Covid-19 Pneumonia: An Increasingly Promising Biochemical Target
Authors: Turnic Tamara Nikolic , Popadic Viseslav , Klasnja Slobodan , Sekulic Ana , Nikolic Novica , Zivkovic Vladimir , Jeremic Nevena , Andjic Marijana , Draginic Nevena , Srejo Ivan , Jeremic Jovana , Zdravkovic Marija , Jakovljevic Vladimir Lj. 
Published: May 2022

Abstract
Still, there are no curative or preventive strategies for COVID-19, noting the importance of understanding the pathogenesis of COVID-19 infections for the rational development of pharmacological protocols. Considering the proinflammatory, oxidative and other roles of BK and Galectin-3, it is more than relevant to investigate the clinical repercussion of that molecules in patients who survived and died after COVID-19 confirmed pneumonia. This was prospective cross-sectional study which included 47 adult patients with confirmed SARS-CoV-2 infection and with criteria for hospital treatment who are admitted to tertiary Clinical Center “Bezanijska kosa” during June of 2021. Our study strongly supports the bradykinin storm hypothesis which underlying in many of COVID-19 fatal outcomes. In that sense, future therapeutical strategies must be focused on reducing a bradykinin serum concentration in COVID-19 patients. “Bradykinin storm” and oxidative stress in patients with fatal outcome are probably responsible for the overactive inflammatory response in COVID-19 patients and resulting symptoms. Understanding the mechanisms by which the two storms, bradykinin and cytokine, affect the body, separate or together, is crucial to mitigating the pandemic’s effect, saving lives, and producing effective treatments that we presently lack.
Osteophytes mediate the associations between cartilage morphology and changes in knee symptoms in patients with knee osteoarthritis
Authors: Fan Tianxiang , Li Jia , Zeng Muhui , Wang Xiaoshuai , Ruan Guangfeng , Cao Peihua , Zhang Yan , Chen Tianyu , Chen Shibo , Ou Qianhua , Wang Qianyi , Wluka Anita E , Cicuttini Flavia , Ding Changhai , Zhu Zhaohua 
Published: May 2022

Abstract
Aims: To investigate whether the associations between cartilage defects and cartilage volumes with changes in knee symptoms were mediated by osteophytes.Methods: Data from Vitamin D Effects on Osteoarthritis (VIDEO) study were analyzed as a cohort. Western Ontario and McMaster Universities Osteoarthritis Index was used to assess knee symptoms at baseline and follow-up. Osteophytes, cartilage defects and cartilage volumes were measured using magnetic resonance imaging at baseline. Associations between cartilage morphology and changes in knee symptoms were assessed using linear regression models, and mediation analysis was used to test whether these associations were mediated by osteophytes. Results: 334 participants (aged 50 to 79 years) with symptomatic knee osteoarthritis were included in the analysis. Cartilage defects were significantly associated with change in total knee pain, change in weight-bearing pain and change in non-weight-bearing pain after adjustment for age, sex, body mass index and intervention. Cartilage volume was significantly associated with change in weight-bearing pain and change in physical dysfunction after adjustment. Lateral tibiofemoral and patellar osteophyte mediated: the associations of cartilage defects with change in total knee pain (49%-55%) and change in weight-bearing pain (61%-62%); the association of cartilage volume with change in weight-bearing pain (27%-30%) and dysfunction (24%-25%). Both cartilage defects and cartilage volume had no direct effects on change in knee symptoms.Conclusions: The significant associations between cartilage morphology and changes in knee symptoms were indirect and were partly mediated by osteophytes.
Resveratrol protects against IL-1β-induced chondrocyte damage via the SIRT1/FOXO1 signalling pathway
Authors: Liang ChuanCai , Xing Hengte , Wang ChenYu , Xu XiongFeng , Hao Yarong , Qiu Bo 
Published: May 2022

Abstract
PurposeOsteoarthritis (OA) is a common joint disease characterized by cartilage degeneration, synovial inflammation, osteophytes, and subchondral osteosclerosis. The present study aimed to investigate the effects of RES on in the extracellular matrix ，autophagy and apoptosis in the process of osteoarthritis via the SIRT1/FOXO1 pathway. MethodsThe microenvironment of OA chondrocytes was simulated in vitro by adding 10 ng/mL of IL-1β to primary Wistar rat chondrocyte culture flasks. Western blotting, immunohistochemistry, transmission electron microscopy was used.ResultsIn the presence of IL-1β, RES increased the expression of SIRT1 protein and the phosphorylation level of FOXO1, promoted the expression of autophagy genes (LC3, ATG5 and Beclin-1) and matrix synthesis genes (SOX9 and Aggrecan), inhibited the expression of pro-apoptosis related genes (caspase-3 and BCL-2) and matrix catabolic genes (MMP13 and ADAMT) and protected chondrocytes from IL-1β damage. Inhibition of SIRT1 prevents the reduction of IL-1β -induced chondrocyte damage in the presence of RES. Inhibition of FOXO1, but not SIRT1, reduced the expression of FOXO1 phosphorylation. Our results suggest that RES regulates extracellular matrix metabolism, autophagy and apoptosis of OA chondrocytes through the SIRT1/FOXO1 pathway to ameliorate IL-1β -induced chondrocyte injury.ConclusionRES protects against IL-1β-induced chondrocyte damage by activating SIRT1/FOXO1 signaling. RES provides insight into the treatment of osteoarthritis.
Mortality Predictors Of Pre-variant SARS-CoV-2 Infected ARDS Patients Receiving Favipiravir and Tocilizumab
Authors: YILDIRIM Fatma , ŞİMŞEK Meltem , APAYDIN Muhammed , KARAMAN İrem , DURAL Halil İbrahim 
Published: May 2022

Abstract
Objective
In this study, viral clearance (oronasopharyngeal swab RT-PCR negativity) and intensive care outcomes and risk factors affecting mortality of critically ill patients with COVID-19-related acute respiratory distress syndrome (ARDS) who received tocilizumab and favipiravir treatments together before vaccination were investigated.
Material-Methods
The data of patients who were followed up and treated between 1 July 2020 and 5 October 2020 were retrospectively analyzed. Demographic data of the patients (age, gender), oro-nasopharyngeal swab RT-PCR and classification of ARDS, respiratory support treatments, all medical treatments, and ICU outcomes were recorded.
Results
Totally, 60 patients with a median age of 69.8 [24–87], 25 females and 35 males were included in the study. Mean APACHE II score was 18.9 ± 8.0; and SOFA score was 4.5 ± 2.0. Thirty-four (56.7%) patients were intubated during follow-up. Tocilizumab was given on average of 2.5th day (± 2.0 days). On the day of tocilizumab administration, 1 (1.7%) patient had mild ARDS, 30 (50.0%) had moderate ARDS, 29 (48.3%) had severe ARDS. PaO2/FIO2 on the day of tocilizumab administration was 96.7 ± 36.6 mmHg. Forty (66.7%) patients died, while 20 (33.3%) patients transferred to the service. The mean length of stay in the ICU was 11.4 ± 5.5 days. Advanced age [Hazard ratio (HR) 1.8; 95% confidense interval (CI) 0.88–0.93; p < 0.001), higher APACHE II score (HR 0.81, 95% CI 0.74–0.98; p = 0.001), higher SOFA score on the day of tocilizumab administration (HR 1.47, 95% CI 0.39–0.79; p = 0.001), and lower PaO2/FIO2 ratio (HR 2.54, 95% CI 2.33–3.79; p < 0.001) were determined as independent risk factors for mortality.
Conclusion
Patients who were administered tocilizumab and favipiravir together in our intensive care unit were mostly patients with severe ARDS and had higher inflammatory markers. High mortality was attributed to the use of tocilizumab as an add-on treatment, not as a routine treatment.
A Study of The Widespread of Anxiety, Stress and Depression of Thalassemia Patients Among Thalassemia Centers in Damascus
Authors: Mohammad Amena Abbas Alhaj , Alhajji Esraa Trad , A.Kadri Saeed , Alhouri Ahmad 
Published: May 2022

Abstract
Background
Thalassemia is a congenital blood condition, which patients require blood transfusions and are vulnerable to a variety of complications. DAS (depression, anxiety, and stress) can make their situation worse. Syrian Arab republic has no reports on measuring DAS in thalassemia patients. The DASS-21 (Depression, Anxiety, and Stress Scale − 21 Items) assessment is used to evaluate the incidence of DAS symptoms in our thalassemia patients.
Methods
A cross-sectional study was conducted on teens and adults aged 12 and up who had thalassemia and were treated in Damascus centers for thalassemia, omitting patients who is below 12 years.
Results
There were 67 male and 93 female patients in all, with a largest percentage age group was between 16–20 years. 48 (30%) and 59 (36.7%) of patients received blood transfusions every two weeks and monthly, respectively. 40.6% of patients did not remember to take their prescription and did not commit to taking it more than twice a week. 72% of patients had depression symptoms, 79% of the patients had anxiety symptoms, and 69% of patients had stress symptoms.
Conclusion
Patients with thalassemia are more prone to developing psychiatric issues, which can have an impact on the disease's progression. Our findings are comparable to those of national and Arab community research, which have revealed the greatest prevalence rates. Patients with thalassemia should have their psychological evaluations done and should be referred for adequate monitoring and treatment.
Analysis of static var compensator-based distance protection of transmission network considering different line lengths: a case study of nigerian grid
Authors: Alayande Akintunde Samson , Popoola Olawale , Akinbode Sunday Oluwagbenga 
Published: May 2022

Abstract
This paper presents a Matlab/Simulink-based approach for investigating the performance of Static Var Compensators (SVCs) on distance relay protection installed at varying lengths of the practical Nigerian 132-kV sub-transmission grid system. The shunt-connected SVC is located at the Ikorodu sub-station end of the Ikorodu-Sagamu 132-kV transmission line. The faults are simulated on a short line (18.4 km), medium line (100 km) and long line (226 km) in the Matlab/Simulink model of the Ikorodu-sagamu 132kV sub-transmission distance protection scheme. The results obtained are then used to investigate the impact SVCs have on distance protection relays when they are connected and disconnected for varying transmission line lengths whilst keeping all other parameters constant. The results obtained show that the SVC despite being advantageous, also introduces under-reach and over-reach tendencies for different zone faults (zones 1 and 2) as simulated on varying lengths of 132-kV transmission lines. This implies that a further simulation is required to recommend measures aimed at reducing the error margin introduced by the SVCs.
Fate of microplastics in background headwater lake catchments using a particle balance approach
Authors: Welsh Brittany , Aherne Julian , Paterson Andrew , Yao Huaxia , McConnell Chris 
Published: May 2022

Abstract
Microplastics are pervasive contaminants of concern, yet their fate in headwater lakes, especially in background regions, remains relatively unknown. Further, few field studies have quantified the inputs, outputs, and pathways of microplastics at the catchment level. In this study, the flux of microplastics (MP) were quantified over a 12-month period for three background headwater lake catchments in Muskoka-Haliburton, Ontario, Canada. A microplastic particle balance approach was used, incorporating inputs from atmospheric deposition and stream inflows against outflows and sedimentation to lakes. Atmospheric deposition had the highest daily microplastic flux rate (3.84–8.04 MP/m2/day), suggesting that it is the dominant source of microplastics to lakes in background regions. Of the microplastics deposited on the catchment, 41–73% were retained in the terrestrial area. Furthermore, a large fraction of the microplastics entering the lake were retained (30–45%), suggesting that lakes are a reservoir for microplastics. The microplastic residence time for the study lakes ranged from 3.15 to 7.70 years. Fibres (> 60%) were the most common particle type, further, polyethylene terephthalate was the dominant polymer identified followed by polypropylene and polyamide.