bluuebunny/crossref_metadata_2025_split huggingface dataset:
TNF Receptors Choose HSC Fate in SupportingDnmt3a-Mutant Clonal Hematopoiesis
Authors: Niño Katia E. , Pietras Eric M. 
Published: December 2022

Summary:TNFα receptor signaling distinctly promotes self-renewal and lymphoid differentiation in Dnmt3a-mutant hematopoietic stem cells, contributing to clonal hematopoiesis of indeterminate potential.See related article by SanMiguel et al., p. 2763 (3).
Expectancy Effects Threaten the Inferential Validity of Synchrony-Prosociality Research
Authors: Atwood S. , Schachner Adena , Mehr Samuel A. 
Published: December 2022

Abstract
Many studies argue that synchronized movement increases prosocial attitudes and behavior. We reviewed meta-analytic evidence that reported effects of synchrony may be driven by experimenter expectancy, leading to experimenter bias; and participant expectancy, otherwise known as placebo effects. We found that a majority of published studies do not adequately control for experimenter bias and that multiple independent replication attempts with added controls have failed to find the original effects. In a preregistered experiment, we measured participant expectancy directly, asking whether participants have a priori expectations about synchrony and prosociality that match the findings in published literature. Expectations about the effects of synchrony on prosocial attitudes directly mirrored previous experimental findings (including both positive and null effects)—despite the participants not actually engaging in synchrony. On the basis of this evidence, we propose an alternative account of the reported bottom-up effects of synchrony on prosociality: the effects of synchrony on prosociality may be explicable as the result of top-down expectations invoked by placebo and experimenter effects.
The introduction of three cryptic tree frog species in the Dutch coastal dunes challenges conservation paradigms
Authors: Kuijt Marit , Oskam Liam , den Boer Ingrid , Dufresnes Christophe , France James , Gilbert Maarten J. , de Visser Manon C. , Struijk Richard P.J.H. , Wielstra Ben 
Published: December 2022

Abstract
Invasive species are considered one of the main drivers of the sixth mass extinction. Conservation solutions depend on whether a species is also indigenous to the country it invades (i.e., beyond its native range). In the case of invasive cryptic species, genetic tools are required to establish their identity. We illustrate these issues with the human-mediated colonization of the Dutch coastal dunes by Hyla tree frogs. Although previously assumed to concern the indigenous common tree frog H. arborea, European tree frogs comprise a complex of allopatric cryptic species, meaning the taxonomic identity of introduced Dutch populations warrants investigation. We sequence mtDNA for 173 individuals from native and introduced populations across the Netherlands and compare our dataset with hundreds of Hyla haplotypes previously barcoded in the Western Palearctic. Two of the dune populations carry an mtDNA haplotype of the native species H. arborea that occurs naturally elsewhere in the Netherlands. In contrast, mtDNA assigned to the eastern tree frog H. orientalis was detected in all three other dune populations. In one of these populations mtDNA of the Italian tree frog H. intermedia was also found. Not one, but three species of tree frogs have thus been introduced to the Dutch coastal dunes, only one of them being native to the Netherlands. This situation causes a conservation conundrum as some introduced populations are lawfully protected but could pose a threat to local biodiversity. Regarding the ‘true’ exotic tree frog species, all conservation options should be considered.
Dynamic Weighting of Time-Varying Visual and Auditory Evidence During Multisensory Decision Making
Authors: Tuip Rosanne R. M. , van der Ham Wessel , Lorteije Jeannette A. M. , Van Opstal Filip 
Published: December 2022

Abstract
Perceptual decision-making in a dynamic environment requires two integration processes: integration of sensory evidence from multiple modalities to form a coherent representation of the environment, and integration of evidence across time to accurately make a decision. Only recently studies started to unravel how evidence from two modalities is accumulated across time to form a perceptual decision. One important question is whether information from individual senses contributes equally to multisensory decisions. We designed a new psychophysical task that measures how visual and auditory evidence is weighted across time. Participants were asked to discriminate between two visual gratings, and/or two sounds presented to the right and left ear based on respectively contrast and loudness. We varied the evidence, i.e., the contrast of the gratings and amplitude of the sound, over time. Results showed a significant increase in performance accuracy on multisensory trials compared to unisensory trials, indicating that discriminating between two sources is improved when multisensory information is available. Furthermore, we found that early evidence contributed most to sensory decisions. Weighting of unisensory information during audiovisual decision-making dynamically changed over time. A first epoch was characterized by both visual and auditory weighting, during the second epoch vision dominated and the third epoch finalized the weighting profile with auditory dominance. Our results suggest that during our task multisensory improvement is generated by a mechanism that requires cross-modal interactions but also dynamically evokes dominance switching.
Volumetric imaging by micro computed tomography: a suitable tool for wood identification of charcoal
Authors: Haag Volker , Dremel Kilian , Zabler Simon 
Published: December 2022

Summary
The present study focuses on the application of state-of-the-art μCT, by using a sub-micrometre CT scanner as a tool for wood identification. Charcoal was chosen as a subject for this case study. The reason for choosing charcoal is based on economic as well as technical issues. Parallel to conventional wood anatomy, various promising approaches to identification are currently being developed worldwide in order to simplify the identification of processed wood. However, due to the carbonization process, such approaches are not applicable to charcoal. In view of the rapid development of μCT technology, it was decided to examine the extent to which wood anatomical studies can be supported and improved by modern μCT technology. About 17% of the annually harvested wood worldwide is converted to charcoal (FAO 2017), and the charcoal trade is one of the least controlled/monitored segments of the European timber market. Although charcoal has a significant market share of wood-based products, it is still not yet covered by any trade regulation, e.g. the European Timber Regulations (EUTR), (EU) No995/2010. For the present study, different wood types and the anatomical fine structural features were measured and displayed at different magnifications to visualize the performance of state-of-the-art μCT standards. Three different charcoal assortments were examined, and the results were checked against the given declarations of contents. The aim of this work is to evaluate the potential of the μCT technique in the field of wood identification and to assess its use for the regulatory control of charcoal and other wood products in the international timber trade. The results are encouraging and lead to the conclusion that the application of the μCT technique in the field of wood identification can be classified as very promising for the future.
Results from a Pseudo-Real-Time Next-Generation 1-km Warn-on-Forecast System Prototype
Authors: Kerr Christopher A. , Matilla Brian C. , Wang Yaping , Stratman Derek R. , Jones Thomas A. , Yussouf Nusrat 
Published: December 2022

Abstract
Since 2017, the Warn-on-Forecast System (WoFS) has been tested and evaluated during the Hazardous Weather Testbed Spring Forecasting Experiment (SFE) and summer convective seasons. The system has shown promise in predicting high temporal and spatial specificity of individual evolving thunderstorms. However, this baseline version of the WoFS has a 3-km horizontal grid spacing and cannot resolve some convective processes. Efforts are under way to develop a WoFS prototype at a 1-km grid spacing (WoFS-1km) with the hope to improve forecast accuracy. This requires extensive changes to data assimilation specifications and observation processing parameters. A preliminary version of WoFS-1km nested within WoFS at 3 km (WoFS-3km) was developed, tested, and run during the 2021 SFE in pseudo–real time. Ten case studies were successfully completed and provided simulations of a variety of convective modes. The reflectivity and rotation storm objects from WoFS-1km are verified against both WoFS-3km and 1-km forecasts initialized from downscaled WoFS-3km analyses using both neighborhood- and object-based techniques. Neighborhood-based verification suggests WoFS-1km improves reflectivity bias but not spatial placement. The WoFS-1km object-based reflectivity forecast accuracy is higher in most cases, leading to a net improvement. Both the WoFS-1km and downscaled forecasts have ideal reflectivity object frequency biases while the WoFS-3km overpredicts the number of reflectivity objects. The rotation object verification is ambiguous as many cases are negatively impacted by 1-km data assimilation. This initial evaluation of a WoFS-1km prototype is a solid foundation for further development and future testing.

Significance Statement
This study investigates the impacts of performing data assimilation directly on a 1-km WoFS model grid. Most previous studies have only initialized 1-km WoFS forecasts from coarser analyses. The results demonstrate some improvements to reflectivity forecasts through data assimilation on a 1-km model grid although finer resolution data assimilation did not improve rotation forecasts.
“Real-Life Needs”: How Humanitarian Techniques Produce Hierarchies of Science and Mathematics Education
Authors: Kirchgasler Kathryn L. , Yolcu Ayşe 
Published: December 2022

Background and Context: Racialized disparities in curricular tracking have long been ascribed to narrow tests that create a hierarchy of perceived ability. Consequently, teachers are urged to reject deficit views of ability and embrace more expansive techniques to reveal and respond to the real-life needs of students, especially those from minoritized groups. Paradoxically, these tools, upheld as equity strategies today, had prior careers racializing populations along a hierarchy of perceived needs. That hierarchy, which gave a humanitarian basis for curricular tracking, continues to produce racializing effects today. Purpose: This article rethinks how teachers are taught to distinguish the real-life needs of students from marginalized communities. As a history of the present, it examines how demographic distinctions in health-related needs emerged historically and became tied to lower track science and mathematics instruction. We ask: To what extent do current strategies persist in dividing populations and prescribing distinct pedagogies? Have the normalizing impulses of past tools been removed or rearticulated in recent reforms that promote educational and health equity? Research Design: We first analyzed articles reviewed as exemplary of culturally responsive science and mathematics education to identify techniques recommended to uncover students’ real-life needs. Next, we compared these techniques with similar tools promoted in early 20th-century U.S. science and mathematics education journals, when these fields began distinguishing types of students and matching them with distinct tiers of instruction. Conclusions: Despite key shifts over the century (e.g., from treating inherent pathologies to redressing inequities), similar tools operate as humanitarian techniques today. That is, they classify populations as having “immediate needs” for intervention in daily life that preempt “future needs” for academic preparation. The resulting hierarchy of perceived needs orders students and subject matter from applied relevance to abstract rigor. This yields four dangers: (1) positing target students and families as not-yet-capable of self-direction, (2) prioritizing for target groups an applied and often lower prestige curriculum with consequences for their academic trajectories, (3) depoliticizing systemic inequities as problems of attitude adjustment, and (4) depoliticizing mainstream science and mathematics education by isolating sociopolitical concerns as compensatory interventions. We argue that school science and mathematics are not unique in these respects but epitomize risks present whenever social scientific tools offer an ostensibly neutral basis for seeing and sorting difference.
Association of Psychological distress and Physical Health with Subjective and Objective Memory in Older Adults
Authors: Liu Zhong-Xu , Whitehead Brenda , Botoseneanu Anda 
Published: December 2022

Objectives To investigate how indicators of psychological stress and physical health differentially influence subjective and objective memory in older adults. Methods: 404 adults aged ≥55 without cognitive impairment participated in remote assessment of physical health (PHY; multimorbidity, body-mass-index), psychological distress (PDS; perceived stress, anxiety, depression), subjective memory complaints (SM), and task-based objective memory performance (OM). Results: Separately, both PHY and PDS significantly predicted SM ( p < 0.01), but only PHY was associated with OM ( p = 0.05). Combined models showed that PHY and PDS maintained significant association with SM ( p < 0.01, R2 = 0.30), while only PHY was associated with OM ( p = .07, R2 = 0.03; for associative OM, p = 0.04). Discussion: SM is associated with participants’ psychological profile, highlighting the importance of addressing these factors when assessing SM. The results also reveal that remotely-administered OM tasks are more immune to participants’ psychological profile, and support previously-established links between physical health and objective and subjective memory function.
The protective effects of red ginseng and amifostine against renal damage caused by ionizing radiation
Authors: Yilmaz Hamit , Karakoc Yunus , Tumkaya Levent , Mercantepe Tolga , Sevinc Hacer , Yilmaz Adnan , Yılmaz Rakıcı Sema 
Published: December 2022

This study aimed to elucidate the effects of amifostine (ethyol) (AM), a synthetic radioprotector, and red ginseng (RG), a natural radioprotective agent, against the toxic effect of ionizing radiation (IR) on kidney tissues through changes in biochemical and histopathological parameters in addition to contributions to the use of amifostine and RG in clinical studies . Five groups were established: Group I (control, receiving only saline by gavage), Group II (IR only), and Group III (IR+AM, 200 mg/kg intraperitoneally (i.p.). Group IV (IR + RG, 200 mg/kg orally once a day for 4 weeks), and Group V (IR+RG+AM, 200 mg/kg orally once/day for 4 weeks before IR and 200 mg/kg AM administered (i.p.) 30 min before IR). All groups, except for the control group, were subject to 6-Gy whole-body IR in a single fraction. 24 h after irradiation, all animals were sacrificed under anesthesia. IR enhanced MDA, 8-OHdG, and caspase-3 expression while decreasing renal tissue GSH levels ( p < .05). Significant numbers of necrotic tubules together with diffuse vacuolization in proximal and distal tubule epithelial cells were also observed. The examination also revealed substantial brush boundary loss in proximal tubules as well as relatively unusual glomerular structures. While GSH levels significantly increased in the AM, RG, and AM+RG groups, a decrease in KHDS, MDA, 8-OHdG, and caspase-3 expression was observed, compared to the group subject to IR only ( p < .05). Therefore, reactive oxygen species-scavenging antioxidants may represent a promising treatment for avoiding kidney damage in patients receiving radiation.
Modified scarf osteotomy for hallux valgus: From a finite element model to clinical results
Authors: Li Yan , Wang Yue , Tang Kanglai , Tao Xu 
Published: December 2022

Purpose Finite element (FE) analysis and clinical follow-up were used to evaluate the efficacy of modified scarf osteotomy for moderate-to-severe hallux valgus (HV). Method We retrospectively evaluated 42 patients (44 feet) who underwent modified rotational scarf osteotomy for moderate-to-severe HV at our institution between January 2010 and January 2019. Radiological indicators and subjective scores were recorded at different time points. To compare the results and elemental characteristics, a FE model of the metatarsophalangeal (MTP) joint that included anatomically realistic geometrical and structural characteristics was built. The biomechanical features and correction differences in dynamic loads as well as the incidence of troughing were estimated. Results Both the hallux valgus angle (HVA) and intermetatarsal angle (IMA) showed significant improvement 6 weeks postoperatively ( p < 0.05); additionally, the HVA increased from 6 weeks postoperatively to the last follow-up, while the IMA showed no significant changes ( p > 0.05). The subjective scores significantly improved from the preoperative period to the last follow-up. The percentages of troughing and recurrence were remarkably low in our pilot study because of the innate stability of the modified rotated fixation. Conclusion Our preliminary findings suggest that modified rotational scarf osteotomy offers sufficient stability, correct HV deformity effectively, and good clinical outcomes for moderate to severe HV.
Digital Gaming Trends of Middle-Aged and Older Adults: A Sample from Turkey
Authors: Seçer İlmiye , Us Elif Öykü 
Published: December 2022

Background Although the gaming habits of children, adolescents, and younger adults have been investigated in Turkey there has been less emphasis on the gaming patterns of middle-aged and older adults. The current study therefore investigated middle-aged and older adults' digital gaming habits, the aspects of digital games that they believe are enjoyable and any perceived psychological and cognitive advantages. Methods Of the 177 middle-aged and older adults aged between 55 and 85 years ( M = 62) living in Turkey who partook in the study, data from 140 participants were analyzed. Participants completed the ‘Demographic Information Form’ and Engagement with Digital Games Questionnaire’ via a Qualtrics link that was distributed on social media platforms and using the convenience and snowball sampling technique. Results Findings of this study showed that out of the 57 digital game players, the majority ( N = 34) reported to play puzzle games such as Candy Crush. Moreover, gamers indicated that they believed digital games had psychological and cognitive benefits. Conclusion Overall, the findings of the current study revealed that middle-aged and older adults enjoy playing digital games for fun, stress relief, and as a mental exercise regime.
From Bedside to Bench and Back: Advancing Our Understanding of the Pathophysiology of Cleft Palate and Implications for the Future
Authors: Stanton Eloise , Sheridan Samuel , Urata Mark , Chai Yang 
Published: December 2022

Objective To provide a comprehensive understanding of the pathophysiology of cleft palate (CP) and future perspectives. Design Literature review. Setting Setting varied across studies by level of care and geographical locations. Interventions No interventions were performed. Main Outcome Measure(s) Primary outcome measures were to summarize our current understanding of palatogenesis in humans and animal models, the pathophysiology of CP, and potential future treatment modalities. Results Animal research has provided considerable insight into the pathophysiology, molecular and cellular mechanisms of CP that have allowed for the development of novel treatment strategies. However, much work has yet to be done to connect our mouse model investigations and discoveries to CP in humans. The success of innovative strategies for tissue regeneration in mice provides promise for an exciting new avenue for improved and more targeted management of cleft care with precision medicine in patients. However, significant barriers to clinical translation remain. Among the most notable challenges include the differences in some aspects of palatogenesis and tissue repair between mice and humans, suggesting that potential therapies that have worked in animal models may not provide similar benefits to humans. Conclusions Increased translation of pathophysiological and tissue regeneration studies to clinical trials will bridge a wide gap in knowledge between animal models and human disease. By enhancing interaction between basic scientists and clinicians, and employing our animal model findings of disease mechanisms in concert with what we glean in the clinic, we can generate a more targeted and improved treatment algorithm for patients with CP.
Polymorphisms in IL-17A Gene and Susceptibility of Colorectal Cancer in Bangladeshi Population: A Case-Control Analysis
Authors: Islam Md. Robiul , Aziz Md. Abdul , Shahriar Mohammad , Islam Mohammad Safiqul 
Published: December 2022

Objective Interleukin-17A ( IL-17A) genetic polymorphisms are associated with multiple cancer types, including colorectal cancer (CRC). However, no previous study was performed in the Bangladeshi population to evaluate the association. Our study aimed to find the association between two IL-17A variants (rs10484879 C/A and rs3748067 G/A) and susceptibility of CRC. Methods and Materials This retrospective case-control study comprised 292 CRC patients and 288 age, sex, and BMI matched healthy volunteers. Genotyping of both variants was done by the tetra-primer ARMS-PCR method, and the results were analyzed by the SPSS software package (version-25.0). Results Logistic regression analysis indicated that in case of IL-17A rs10484879 polymorphism, AC and AA genotype carriers showed 2.44- and 3.27-times significantly increased risk for CRC development (OR = 2.44, P = .0008 and OR = 3.27, P = .0133, individually). A significant association was also observed for AC + AA genotype (OR = 2.58, P = .0001). Again, over-dominant and allelic model revealed statistically significant link to CRC risk (OR = 2.13, P = .0035 and OR = 2.22, P = .001). For rs3748067 polymorphism, AG and AA genotype carriers showed 2.30- and 2.45-times enhanced risk for CRC (OR = 2.30, P = .005 and OR = 2.45, P = .031). A statistically significant association was also observed for AG + AA genotype (OR = 2.35, P = .001), over-dominant model (OR = 2.05, P = .014), and allelic model (OR = 2.11, P = .0004). Conclusion This study highlights that IL-17A rs10484879 and rs3748067 polymorphisms may be associated with CRC development. However, further functional research with larger samples may reveal more statistically significant outcomes.