bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boswellia serrata Extract as an Antibiofilm Agent against Candida spp.
Authors: Jaroš Petr , Vrublevskaya Maria , Lokočová Kristýna , Michailidu Jana , Kolouchová Irena , Demnerová Kateřina 
Published: January 2022

The use of antibiotics or antifungals to control infections caused by pathogenic microorganisms is currently insufficiently effective because of their emerging resistance. Thanks to the ability of microorganisms to form a biofilm and thus increase their resistance to administered drugs even more, modern medicine faces the task of finding novel substances to combat infections caused by them. In this regard, the effects of essential oils or plant extracts are often studied. Among the relatively neglected plants is Boswellia serrata, which has a high content of biologically active boswellic acids. In this study, we focused on one of the most common nosocomial infections, which are caused by Candida species. The most common representative is C. albicans, although the number of infections caused by non-albicans species has recently been increasing. We focused on the antifungal activity of Boswellia serrata extract Bioswellix against planktonic and adhering cells of Candida albicans, Candida parapsilosis and Candida krusei. The antifungal activity against adhering cells was further explored by determining the metabolic activity of cells (MTT) and determining the total amount of biofilm using crystal violet. Boswellic acid-containing plant extract was shown to suppress the growth of a suspension population of all tested Candida species. Boswellia serrata extract Bioswellix was most effective in inhibiting C. albicans biofilm formation.
Nanostructured Lipid Carriers Loaded with Lippia sidoides Essential Oil as a Strategy to Combat the Multidrug-Resistant Candida auris
Authors: Baldim Iara , Paziani Mario H. , Grizante Barião Patrícia H. , Kress Marcia R. von Zeska , Oliveira Wanderley P. 
Published: January 2022

The emerging pathogen Candida auris is an emerging fungal pathogen that was associated with nosocomial infectious outbreaks. Its worldwide incidence and the emerging multidrug-resistant strains highlight the urgency for novel and effective antifungal treatment strategies. Lippia sidoides essential oil (LSEO) proved antifungal activity, including anti-Candida. However, it may undergo irreversible changes when in contact with external agents without adequate protection. Herein, we encapsulated LSEO in nanostructured lipid carriers (NLC) through the hot emulsification method followed by sonication. NLC matrix was based on oleic acid and Compritol® 888, or a combination of carnauba wax and beeswax, stabilized by sodium dodecyl sulfate. Eight formulations were produced and characterized by the determination of the particle size (213.1 to 445.5 nm), polydispersity index (around 0.3), and ζ-potential (−93.1 to −63.8 mV). The antifungal activity of nanoparticles and LSEO against C. auris and the in vivo toxicity in Galleria mellonella model were also evaluated. Both NLC and LSEO exhibited potent activity against the yeast, with Minimum Inhibitory Concentration between 281 and 563 µg/mL, and did not evidence toxicity in the in vivo model. Therefore, this study confirms the viability of NLCs loaded with LSEO in combating drug-resistant pathogens as a potential new therapeutic strategy for managing of candidemia.
Tingkat Pengetahuan Masyarakat tentang Covid-19 dan Perilaku Masyarakat di Masa Pandemi Covid-19
Authors: Mukhlis Siti Hidayati , Karminingtyas Sikni Retno 
Published: January 2022

Covid-19 merupakan penyakit infeksi pernafasan yang disebabkan oleh SARS-COV2. Pandemi Covid-19 dianggap sebagai bencana kesehatan global yang paling krusial pada abad ini dan tantangan terbesar yang dihadapi umat manusia sejak Perang Dunia ke-2. Jumlah kasus di Indonesia terus meningkat setiap hari dan mengakibatkan ancaman bagi masyarakat dalam hal kesehatan, ekonomi, dan sosial. Tujuan penelitian ini untuk mengetahui tingkat pengetahuan masyarakat tentang Covid-19 dan perilaku masyarakat di masa pandemi Covid-19 di Desa Montong Beter Kecamatan Sakra Barat. Jenis penelitian ini adalah deskriptif analitik dengan pendekatan Cross-Sectional Study. Jumlah sampel 100 responden dengan metode pengambilan consecutive sampling menggunakan kuesioner google form dan disebarkan melalui WhatsApp. Hasil penelitian menunjukkan tingkat pengetahuan masyarakat dalam kategori baik yaitu sebanyak 85 responden (85%). Perilaku masyarakat Desa Montong Beter di masa pandemi Covid-19 terkait upaya dalam pencegahannya dalam kategori cukup baik yaitu sebesar 54 responden (54%). Uji gamma diperoleh nilai p 0,005 (sig <0,05) dan koefisien korelasi 0,657 yang menunjukkan bahwa terdapat hubungan yang kuat antara pengetahuan masyarakat dengan perilaku pencegahan Covid-19. Simpulan penelitian ini pengetahuan masyarakat dalam kategori baik, sedangkan perilaku masyarakat dalam kategori cukup baik dan terdapat hubungan antara pengetahuan dengan perilaku masyarakat dalam upaya pencegahan Covid-19.
Genetic Risk Factors for Idiopathic Urolithiasis: The Causative Role of Genes in Stones Formation
Authors: Susilo Jatmiko 
Published: January 2022

Background: The genetic factor of urolithiasis plays an important role in the etiology. Elucidation of responsible genes can lead to better targeted gene therapy and prevention in the future. This article aims to explain various genetic factors that play a role in kidney stone formation Method: A review article on urolithiasis based on a genetic approach is reported to underlie stone formation. A total of 41 abstracts and research articles published by internationally reputed journals were selected based on the keywords genetic factors and urolithiasis. Summary: A deeper understanding of the genetic factors that play a role in the mechanisms of stone formation and advances in molecular and pharmacogenomics have revolutionized diagnosis and treatment, and paved the way for the identification of new therapeutic targets and treatment approaches based on genetic engineering.
Evaluasi Ketepatan Obat Dan Dosis Obat Antihipertensi Terhadap Keberhasilan Terapi Pada Pasien Hipertensi Rawat Jalan Di Rumah Sakit Bhakti Wira Tamtama Semarang
Authors: Wycidalesma Wycidalesma , Yuswantina Richa 
Published: January 2022

Hipertensi adalah peningkatan tekanan darah sistolik >140 mmHg dan tekanan darah diastolik >90 mmHg dan merupakan faktor terbesar penyebab mobiditas dan mortalisis. Ketidaktepatan terapi hipertensi dapat menyebabkan terjadinya komplikasi yang dapat memperburuk keadaan penderita.Penelitian ini bertujuan untuk mengetahui ketepatan penggunaan obat dan dosis obat antihipertensi. Penelitian ini merupakan jenis penelitian deskriptif non eksperimental menggunakan pendekatan retrospektif. Jumlah sampel 90 yang memenuhi kriteria inklusi dan eksklusi diambil secara purposive sampling. Analisis data menggunakan program SPSS (Statistic Package for the Social Science) meliputi analisis univariat dan bivariat. Hasil penelitian menunjukkan bahwa ketepatan obat terjadi pada 85 pasien (94,44%). Ketepatan dosis obat terjadi pada 90 pasien (100%)Kata Kunci : Ketepatan, Hipertensi, Obat, Dosis
Business Simulation Training Using Monsoonsim
Authors: Dinata Yuwono Marta , Tanjono Christian , Tanamal Rinabi , Tanuwijaya Evan 
Published: January 2022

Business simulation training has been conducted by the School of Information Technology, Information Systems Department, Ciputra University, using MonsoonSIM. The aim of this activity is to introduce the concept of Enterprise Resource Planning (ERP) to students through virtual business simulation game. This training was conducted online, due to to Covid-19 pandemic. By using MonsoonSIM software, students can manage a virtual company and learn the company's business processes. Learnings in this training were in the form of material module explanations, simulations, discussions, and evaluations. This program was attended by students from Junior High School and Senior High School. Participants not only play individually to learn from the game experience, but also in a team to compete to be the best virtual company that can dominate the market within a predetermined period of time. By participating in this training, students can manage the operational processes of a virtual company, understand existing resources, and can make a company planning strategy in order to survive and grow.
Structural characterization of defects in EFG- and HVPE-grown β-Ga2O3 crystals
Authors: Ueda Osamu , Kasu Makoto , Yamaguchi Hirotaka 
Published: January 2022

Abstract
This paper reviews the status of characterization of defects in β-Ga2O3 crystals grown by edge-defined film-fed growth and hydride vapor phase epitaxy using chemical etching, scanning electron microscopy, focused ion beam scanning ion microscopy, X-ray topography (XRT), and transmission electron microscopy (TEM). The observed defects are classified into four types: dislocations, stacking faults (SFs), twins, and plate-like nanovoids (PNVs). First, we present the detailed characterization of dislocations in the crystal by chemical etching, XRT, and TEM, and discuss possible slip systems. Next, we describe XRT analyses of two types of SFs: SFs 1 lying on the (

2
¯

01

) plane and SFs 2 on the (111) and (

1

1
¯

1

) planes. We describe the results for twins found in crystals via high-resolution TEM and electron diffraction analysis, and PNVs corresponding to etch pits on the (010) plane. Finally, we discuss possible generation mechanisms of the defects and their influence on device characteristics.
Pengaruh Ekstrak Paederia foetida pada Kadar Kolesterol Total Tikus Model Hiperlipidemia yang Diinduksi Deksametason
Authors: Taufik Dhia Farhan , Mukono Indri Safitri , Fatimah Nurmawati 
Published: January 2022

Hiperlipidemia merupakan istilah yang mengacu pada kelainan yang menyebabkan peningkatan profil lipid dalam tubuh manusia. Menurut WHO, secara global, sepertiga penyakit jantung iskemik dikaitkan dengan kadar kolesterol yang tinggi. Peningkatan kadar kolesterol diperkirakan menyebabkan 94,9 juta disability adjusted life year (DALYs) dan 4,32 juta kematian. Penelitian ini bertujuan untuk mengevaluasi pengaruh ekstrak etanol Paederia foetida (EEPF) pada kadar kolesterol total tikus model hiperlipidemia yang diinduksi deksametason. Penelitian Penelitian eksperimen in vivo ini dilakukan dengan menggunakan desain penelitian post-test only complete randomized design (CRD). Proses penelitian dilaksanakan di Departemen Biokimia, Fakultas Kedokteran, Universitas Airlangga, Surabaya, Indonesia, dari bulan Juni 2021 hingga November 2021. Pembuatan EEPF dilakukan dengan metode maserasi pada pelarut etanol 96%. Hewan coba yang digunakan adalah tikus galur Wistar albino jantan berjumlah 30 ekor, sehat, dan berat badan 150-200 gram. Penelitian dilaksanakan dengan membagi rata hewan coba secara acak menjadi kelompok kontrol normal, kontrol patogen, kelompok simvastatin, kelompok EEPF 250 mg/kg, dan kelompok EEPF 500 mg/kg. Sampel darah diambil dari vena pada bagian ekor dan kadar kolesterol total diukur dengan metode point of care testing (POCT). Analisis data dilakukan dengan One-way ANOVA dilanjutkan dengan uji post hoc Dunnett. Hasil penelitian menunjukkan, pemberian deksametason (10 mg/kg) selama 14 hari menyebabkan peningkatan kadar kolesterol total yang signifikan, sedangkan pada kelompok perlakuan simvastatin, EEPF 250 mg/kg, dan EEPF 500 mg/kg terjadi penurunan signifikan pada kadar kolesterol total jika dibandingkan dengan kelompok kontrol patogenik (P<0,001, P<0,05, P<0,05). Pemberian ekstrak etanol Paederia foetida dapat menurunkan kadar kolesterol total pada tikus model hiperlipidemia yang diinduksi deksametason.
Produksi Gas Sintesis Dari Batubara Peringkat Rendah Indonesia Serta Optimasi dan Simulasi Menggunakan Aspen Hysys
Authors: M Irfan Fahmuddin , Harto Andang Widi , Kusnanto Kusnanto 
Published: January 2022

Batubara merupakan salah satu potensi sumber energi yang menggantikan minyak bumi sebagai sumber energi dan bahan baku untuk industri kimia di indonesia. Sekarang ini, sumber batubara di indonesia diestimasikan mencapai 61 juta ton dan 80% dari itu adalah batu bara peringkat rendah (low rank coal). Permasalahan pada penelitian ini ialah untuk mengetahui bagaimana pengaruh dari beberapa faktor seperti temperatur, tekanan, serta aliran massa terhadap syngas yang dihasilkan. Selain itu yang ingin diketahui dari penelitian ini ialah untuk menentukan berapa energi yang dapat dihasilkan dari produksi syngas terhadap energi yang diperlukan dalam proses gasifikasi. Proses gasifikasi batubara untuk menghasilkan syngas yang baik memerlukan kondisi dari berbagai parameter tersebut sehingga optimasi sistem gasifikasi perlu dilakukan untuk menghasilkan syngas dengan kualitas yang baik. Syngas yang baik dapat diketahui dari nilai rasio H2 dan CO yang dapat diatur dengan mengubah parameter reaksi. Model yang digunakan pada penelitian ini telah dirancang dengan menggunakan 2 komponen reaktor untuk menjalankan reaksi gasifikasi serta didorong oleh berbagai komponen pendukung seperti kompresor. Metode optimasi yang dilakukan ialah dengan melakukan variasi nilai dari setiap parameter yang ada didalam pemodelan yang dirancang dengan 3 sampel berbeda dengan kode sampel CQ004, CQ005, dan CQ008. Penentuan jumlah energi yang dihasilkan dapat diketahui dengan mengasumsikan produk syngas tersebut digunakan sebagai bahan bakar dengan reaksi pembakaran sehingga dapat diketahui berapakah energi yang diperoleh dari produk syngas tersebut dan akan dibandingkan dengan nilai energi yang diperlukan dalam produksi.
STRUCTURE OF THE DECISION SUPPORT INFORMATION SYSTEM BY THE NPP OPERATOR
Authors: Ушков М.Е. , Бурковский В.Л. 
Published: January 2022

Рассматривается структура системы информационной поддержки процессов принятия решений оператором АЭС в оперативных условиях. Анализируются функциональные возможности системы информационной поддержки оператора (СИПО) на примере Нововоронежской атомной электростанции (НВ АЭС). Данная система дает возможность оператору, управляющему распределенным комплексом технологических объектов АЭС, проводить качественный анализ и обработку больших объемов сложностpуктурированной информации и принимать своевременные адекватные решения в темпе реального времени. Кроме того, рассматривается объект управления и его структура, приводятся рекомендации, направленные на увеличение функциональных возможностей СИПО на базе искусственных нейронных сетей. Одной из многочисленных функций СИПО является прогнозирование состояния объекта управления на основе реализации программно-технологического комплекса модели энергоблока (ПТК МЭ). Однако существующая модель не способна учесть все факторы, влияющие на производственный процесс. Альтернативой здесь выступает искусственная нейронная сеть, которая в процессе обучения может сформировать искомые зависимости между большим числом параметров объекта управления и получить более полный и достоверный прогноз. Предложена структура искусственной нейронной сети на базе нечёткой системы вывода, которая реализует возможности нейронных сетей и нечеткой логики
We considered the structure of the information support system for decision-making by the NPP operator in operational conditions. We analyzed the functional capabilities of the operator information support system (SIPO) using the example of the Novovoronezh nuclear power plant (NV NPP). This system provides the operator managing the distributed complex of NPP technological facilities to carry out high-quality analysis and processing of large volumes of complex structured information and make timely adequate decisions in real time. In addition, we considered the control object and its structure and made recommendations aimed at increasing the functionality of the SIPO based on artificial neural networks. One of the many functions of the SIPO is to predict the state of the control object based on the implementation of the software and technological complex of the power unit model. However, the existing model is not able to take into account all the factors influencing the production process. An alternative here is an artificial neural network, which in the learning process can form the required dependencies between a large number of parameters of the control object and get a more complete and reliable forecast. The proposed structure of an artificial neural network based on a fuzzy inference system, which implements the capabilities of neural networks and fuzzy logic
MODERN APPROACHES TO DIAGNOSTICS AND REPAIR OF LOW-POWER SWITCHING POWER SUPPLIES
Authors: Ромащенко М.А. , Гудков А.В. 
Published: January 2022

Рассмотрены вопросы оптимизации технологических процессов поиска и устранения неисправностей маломощных DC-DC преобразователей, изготавливаемых ООО «АЕДОН». Перечислены наиболее характерные неисправности, встречающиеся у импульсных источников питания малой мощности. Рассмотрены основные методы поиска и устранения неисправностей, применяемые в процессе диагностики импульсных преобразователей. Предложен подход, основывающийся на комбинировании различных методов диагностики и ремонта, позволяющий увеличить эффективность поиска и устранения неисправностей импульсных DC-DC преобразователей. Рассматриваемый подход позволил повысить оперативность технической диагностики и ремонта в условиях серийного производства, а также был эффективно использован при первоначальной подготовке молодых специалистов участка регулировки и тестирования. В качестве примера представлена процедура поиска и устранения причин повышенного напряжения холостого хода в маломощных импульсных источниках питания. Рассмотрены причины появления дефекта как в одиночных модулях, так и во всей партии. Проведено экспериментальное исследование влияния обратной связи на выходное напряжение модуля в режиме холостого хода, показано влияние возможных неисправностей. В результате применения данной процедуры в короткий срок была произведена диагностика и ремонт маломощного импульсного источника питания (ИИП), выполнена регулировка обратной связи по напряжению
The article considers the issues of optimization of technological processes for troubleshooting low-power DC-DC converters manufactured by company AEDON. We listed the most typical malfunctions that occur in low-power switching power sources. We considered the main methods of troubleshooting used in the process of diagnostics of pulse converters. We propose an approach based on the combination of various diagnostic and repair methods, which allows one to increase the efficiency of troubleshooting of pulsed DC-DC converters. The considered approach allowed us to increase the efficiency of technical diagnostics and repair in the conditions of mass production, and was also effectively used in training of young specialists of the adjustment and testing subdivision. As an example, we present the procedure for finding and eliminating the causes of increased idle voltage in low-power switching power sources. We considered the reasons for the appearance of the defect both in single modules and in the entire batch. We carried out an experimental study of the effect of feedback on the output voltage of the module in the idle mode. We showed the influence of possible failures. As a result of the application of this procedure, we performed diagnostics and repair of a low-power switching power supplies in a short time and adjusted the voltage feedback
DEVELOPMENT OF CALIBRATION MODULES FOR A COMPLEX OF ASSESSING THE IMPACT OF ELECTROMAGNETIC INTERFERENCE ON ELECTRONIC DEVICES
Authors: Пухов Д.А. , Суворин А.В. , Васильченко Д.В. , Ромащенко М.А. 
Published: January 2022

В современном мире при стремлении человечества к миниатюризации электротехнической и радиоэлектронной продукции без потери технических характеристик устройств, наряду с их расширением одной из значимых проблем является влияние электромагнитных помех на стабильное функционирование устройств. Представлены модули калибровки, используемые в программно-аппаратном комплексе (ПАК), который позволяет произвести оценку влияния электромагнитных помех (ЭМП) на электронные средства. Практическое искажение сигналов неизбежно, так как причиной помех может стать взаимное влияние элементов печатной платы (ПП) друг на друга, а также конфигурация самого рисунка дорожек ПП и её топологии. Рассматриваются модули, позволяющие выявить ряд ошибок по ранее полученным результатам и обеспечить калибровку комплекса с целью повышения точности оценки влияния самоиндукции и импеданса линии передач на вносимые искажения сигнала при различных конфигурациях трассировки печатной платы. Применение данного программно-аппаратного комплекса позволяет значительно сократить время, необходимое на разработку устройства и комплекс испытаний, что, в свою очередь, снижает финансовую нагрузку на выпуск единицы продукции, поскольку позволяет выявить недостатки устройств на стадии макетирования электротехнической продукции
In the modern world, with the desire of all mankind to miniaturize electrical products without loss of power, one of the significant problems is the influence of electromagnetic interference on the stable functioning of devices. This article presents the calibration modules used in the software and hardware complex (SHC), which allows one to assess the influence of electromagnetic interference (EMI) on electronic means. The practical distortion of signals is inevitable since the cause of interference can be their mutual influence on each other, as well as the configuration of the printed circuit board pattern itself. The paper considers modules that allow identifying a number of errors based on previously obtained results and providing calibration of the complex in order to increase the accuracy of estimating the effect of self-induction and transmission line impedance on the introduced signal distortion in various configurations of the PCB trace. The use of this software and hardware complex can significantly reduce the development time and conduct tests that require financial costs since it allows one to conduct a number of experiments at the stage of prototyping electrical products