bluuebunny/crossref_metadata_2025_split huggingface dataset:
A protocol for rapid generation cycling (speed breeding) of hemp (Cannabis sativa) for research and agriculture
Authors: Schilling Susanne , Melzer Rainer , Dowling Caroline A. , Shi Jiaqi , Muldoon Shaun , McCabe Paul F. 
Published: December 2022

SUMMARYHemp (Cannabis sativa) is a highly versatile crop with a multitude of applications, from textiles, biofuel and building material to high‐value food products for consumer markets. Furthermore, non‐hallucinogenic cannabinoids like cannabidiol (CBD), which can be extracted from female hemp flowers, are potentially valuable pharmacological compounds. In addition, hemp has high carbon sequestration potential associated with its rapid growth rate. Therefore, the hemp industry is gaining more traction and breeding hemp cultivars adapted to local climate conditions or bred for specific applications is becoming increasingly important. Here, we present a method for the rapid generation cycling (speed breeding) of hemp. The speed breeding protocol makes use of the photoperiod sensitivity of Cannabis. It encompasses vegetative growth of the plants for 2 weeks under continuous light, followed by 4 weeks under short‐day conditions, during which flower induction, pollination and seed development proceed, and finally a seed ripening phase under continuous light and water stress. With the protocol described here, a generation time of under 9 weeks (61 days) from seed to seed can be achieved. Furthermore, our method synchronises the flowering time of different hemp cultivars, thus facilitating crosses between cultivars. The extremely short generation time will enable hemp researchers and breeders to perform crosses in a time‐efficient way and generate new hemp cultivars with defined genetic characteristics over a short period of time.
Influence of cohousing communities on social determinants of health in later life: a scoping review protocol
Authors: Bigonnesse Catherine , Weeks Lori , Puplampu Vivian , Paris Mario , Dupuis-Blanchard Suzanne , McInnis-Perry Gloria J. , Haché-Chiasson Allison 
Published: December 2022

Objective:The objective of this scoping review is to chart the extent and type of literature available worldwide on the effects of cohousing communities on older adults’ social determinants of health, to identify and categorize key evidence on this topic, and to highlight gaps to guide further research.Introduction:The rapid aging population in many industrialized countries has precipitated the development of housing alternatives, such as cohousing communities, to better address older adults’ housing and social needs. There is mounting evidence that living in a cohousing community has many positive outcomes for this population; however, the scope and size of this body of research are unknown.Inclusion criteria:This review will assess studies conducted in all countries and territories focusing on people aged 60 and older living in cohousing communities. It will include quantitative, qualitative, and mixed method studies published from 1960 to 2022.Methods:The databases to be searched are APA PsycArticles (EBSCO), Cairn.info, Campbell Collaboration, CINAHL (EBSCO), Érudit, Google Scholar, JBI, PubMed, SAGE Journals Online, Scopus, Science Direct (Elsevier), Sociological Abstracts (ProQuest), and ProQuest Dissertations and Theses Global (ProQuest). Two independent reviewers will review the titles and abstracts of potential studies against the inclusion criteria for the review followed by an assessment of the full text of selected citations. Data will then be extracted using a data extraction tool developed by the reviewers. The findings will be presented graphically and include tables with a narrative summary organized by relevant geographic areas.
The Longitudinal Mediating Influence of Maturation on the Relationship Between Strength and Performance in Male Youth Swimmers
Authors: Abbott Shaun , En Leong Wei , Gwinn Tom , Postiglione Giovanni Luca , Salter James , Cobley Stephen 
Published: December 2022

Purpose: To examine the longitudinal relationships between shoulder internal and external rotation (IR and ER) strength, maturity status, and swim performance (aim 1). To determine whether maturity status mediated (partially/fully) the relationship between shoulder IR/ER strength and performance in age-group swimmers (aim 2). Methods: Using a repeated-measures design, anthropometrics, maturity status, shoulder IR/ER strength, and 200-m front-crawl velocity were assessed over 3 competition seasons in N = 82 Australian male competitive swimmers (10–15 y). For aim 1, linear mixed models examined longitudinal relationships between assessed variables. For aim 2, causal mediation analyses examined proportional (in)direct contributions of maturity status between shoulder IR strength and swim performance. Results: For aim 1, linear mixed models identified a significant relationship between shoulder IR strength and swim performance over time (F1,341.25 = 16.66, P < .001, marginal R2 = .13, conditional R2 = .91). However, maturity status was influential (ΔAkaike information criterion = −75.8, χ2 = 19.98, P < .001), suggesting removal of the shoulder IR strength–swim velocity relationship (F1,214.1 = 0.02, P = .88). For aim 2, mediation analyses identified maturity status as fully mediating the shoulder IR strength–swim velocity relationship (92.30%, P < .001). Conclusions: Shoulder IR and ER strength did not account for variance in longitudinal age-group swim performance independent of maturity status. Interindividual differences in maturity status fully explained the relationship between shoulder IR/ER strength and swim performance. For practitioners, findings promote the need to account for maturation status and question the rationale for upper-limb strength assessment during maturational years.
Sponge-rich sediment recycling in a Paleozoic continental arc driven by mélange melting
Authors: Liu Huichuan , Nielsen Sune G. , Zhu Guangyou 
Published: December 2022

Abstract
Slab material transfer processes in continental arcs can be challenging to decipher because magmas are often characterized by significant contributions from continental material. In this study, we identified a Prototethyan continental arc (419–418 Ma) that is now located in the Dazhonghe area of the southeast Tibetan Plateau, which, based on Sr-Nd-Hf-O-Si isotope relationships, implies no detectable continental material contributions. The Dazhonghe arc rocks display much lower δ30Si values than modern arc rocks and average mantle; this is best explained by subduction of sponge-rich marine sediments, which are thought to have been the dominant marine organisms during the Neoproterozoic and early Paleozoic. Our mixing calculations reveal that only bulk mixing among sponge-rich sediments, altered oceanic crust (AOC), and the depleted mantle would be capable of accounting for all the Sr-Nd-Hf-O-Si isotope compositions. This finding implies that the Dazhonghe arc magmas were generated by melting of a mélange that formed at the slab-mantle interface. The Dazhonghe continental arc is the first for which mélange melting has been confirmed.
Omental venous malformation: a rare cause of spontaneous haemoperitoneum
Authors: Tan Ming Ngan Aloysius , Ang Wei Wen , Bundele Manish M , Ong Chern Yue Glen 
Published: December 2022

Spontaneous haemoperitoneum is a rare condition with a variety of aetiologies. Regardless of the cause, it is invariably a life-threatening condition that requires urgent diagnosis and management. The most common causes of spontaneous haemoperitoneum include gynaecological, hepatic, splenic and vascular causes. However, here, we present a rare case of spontaneous haemoperitoneum secondary to idiopathic omental venous malformation.Our patient presented with acute onset of right iliac fossa pain, and a CT scan revealed a massive haemoperitoneum. A laparoscopic converted to open laparotomy was performed to diagnose and treat the patient. We discuss the management approach for such patients with spontaneous haemoperitoneum.
Long-lasting insecticidal nets provide protection against malaria for only a single year in Burundi, an African highland setting with marked malaria seasonality
Authors: Van Bortel Wim , Mariën Joachim , Jacobs Bart K M , Sinzinkayo Denis , Sinarinzi Pierre , Lampaert Emmanuel , D’hondt Rob , Mafuko Jean-Marie , De Weggheleire Anja , Vogt Florian , Alexander Neil , Wint William , Maes Peter , Vanlerberghe Veerle , Leclair Corey 
Published: December 2022

BackgroundLong-lasting insecticidal nets (LLINs) are one of the key interventions in the global fight against malaria. Since 2014, mass distribution campaigns of LLINs aim for universal access by all citizens of Burundi. In this context, we assess the impact of LLINs mass distribution campaigns on malaria incidence, focusing on the endemic highland health districts. We also explored the possible correlation between observed trends in malaria incidence with any variations in climate conditions.MethodsMalaria cases for 2011—2019 were obtained from the National Health Information System. We developed a generalised additive model based on a time series of routinely collected data with malaria incidence as the response variable and timing of LLIN distribution as an explanatory variable to investigate the duration and magnitude of the LLIN effect on malaria incidence. We added a seasonal and continuous-time component as further explanatory variables, and health district as a random effect to account for random natural variation in malaria cases between districts.ResultsMalaria transmission in Burundian highlands was clearly seasonal and increased non-linearly over the study period. Further, a fast and steep decline of malaria incidence was noted during the first year after mass LLIN distribution (p<0.0001). In years 2 and 3 after distribution, malaria cases started to rise again to levels higher than before the control intervention.ConclusionThis study highlights that LLINs did reduce the incidence in the first year after a mass distribution campaign, but in the context of Burundi, LLINs lost their impact after only 1 year.
Estimating Chinese bilateral aid for health: an analysis of AidData’s Global Chinese Official Finance Dataset Version 2.0
Authors: McDade Kaci Kennedy , Kleidermacher Paige , Yamey Gavin , Mao Wenhui 
Published: December 2022

BackgroundAlthough it is difficult to quantify, previous estimates suggested that China’s global health aid has increased sharply since the early 2000s. Unlike many donors, China has no official aid reporting obligations, nor does it voluntarily disclose detailed aid information. Our study aimed to create a standardised estimate using commonly accepted definitions of aid and frameworks for categorising health projects.MethodsWe categorised AidData’s Chinese Official Finance Dataset health-related projects according to health aid frameworks from the Organisation for Economic Co-operation and Development (OECD) and the Institute for Health Metrics and Evaluation (IHME). Only projects that complied with the definition of official development assistance were included. We analysed the project count and financial value to assess China’s priority health aid areas.FindingsBetween 2000 and 2017, China funded 1339 health-related aid projects, or 13% of its total aid project portfolio. Most of these projects were located in sub-Saharan Africa. According to the OECD framework, the priority focus areas of these projects were: medical services, such as specialty equipment and tertiary services (n=489, 37%); basic health care, such as basic medical services and drugs (n=251, 19%); malaria control (n=234, 18%) and basic health infrastructure (n=178, 13%). Under the IHME framework, health systems strengthening accounted for 74% (n=991) of total projects, primarily due to China’s contributions to human resources for health, infrastructure and equipment. The only other major allocation under the IHME framework was malaria (n=234, 18%). When we estimated missing financial values under the OECD framework, China was the fifth largest health aid donor to African countries from 2002 to 2017, after the USA, the UK, Canada and Germany.ConclusionOur findings enable a better understanding of Chinese health aid in the absence of transparent aid reporting, which could contribute to better coordination, collaboration and resource allocation for both donor and recipient countries.
Three-year trends in literature on artificial intelligence in ophthalmology and vision sciences: a protocol for bibliometric analysis
Authors: Monson Hayley , Demaine Jeff , Banfield Laura , Felfeli Tina 
Published: December 2022

IntroductionThe aim of this study is to provide an insight into the literature at the intersection of artificial intelligence and ophthalmology.Methods and analysisThe project will be performed in four key stages: formulation of search terms, literature collection, literature screening and literature analysis. A comprehensive search of databases including Scopus, Web of Science, Dimensions and Cochrane will be conducted. The Distiller SR software will be used for manual screening all relevant articles. The selected articles will be analysed via R Bibliometrix, a program for mathematical analysis of large sets of literature, and VOSviewer, which creates visual representations of connections between articles.Ethics and disseminationThis study did not require research ethics approval given the use of publicly available data and lack of human subjects. The results will be presented at scientific meetings and published in peer-reviewed journals.
Homonymous hemianopia in childhood: a systematic scoping review protocol
Authors: Handley Sian , Bowman Richard , Liasis Alki , Rahi Jugnoo Sangeeta 
Published: December 2022

IntroductionCerebral visual impairment (CVI) is the leading cause of visual impairment in childhood in western countries. This encompasses a heterogeneous group of disorders and a spectrum of types of visual impairments. Research is required to explore specific subtypes of CVI and the specific needs of these groups to provide more individualised patient care. One type of CVI is homonymous hemianopia (HH), the absence of vision on one side due to an insult to the postchiasmal visual pathways in one hemisphere of the brain. The scoping review aims to map the nature, features and volume of the existing literature around HH in infancy, childhood and young adolescence.Methods and analysisWe will perform a scoping review of the literature relating to HH in children (0–18 years old). The review will follow the PRISMA extension for scoping reviews checklist to ensure reporting integrity. We will conduct electronic database searches including CENTRAL, CINAHL, MEDLINE (PubMed) and PsycINFO. We will also carry out a ‘grey literature’ and internet search for studies or materials not formally published. Two researchers will independently review abstracts yielded from the search strategy for study inclusion.DisseminationThis review will inform health professionals and other stakeholders working within this growing population of children with CVI. Our review will summarise the literature relating to this specific subgroup of CVI, and will identify gaps that require further research and development towards specific care of children with this form of CVI.
Influence of the EULAR recommendations for the use of imaging in large vessel vasculitis in the diagnosis of giant cell arteritis: results of the ARTESER register
Authors: De Miguel Eugenio , Sanchez-Costa Jesús T , Estrada Paula , Muñoz Alejandro , Valero Martínez Cristina , Moya Alvarado Patricia , García-Villanueva María Jesús , Navarro Angeles Vanessa A , Lencastre Da Veiga Carlos Galisteo , Frutos Anne Riveros , Román Ivorra Jose A , Arrabal Selena Labrada , Rocha Margarida Vasques , Iñiguez Carlota L , García-Gonzalez María , Molina-Almela Clara , Villar María Alcalde , Mas Antonio Juan , Gonzalez-Gay Miguel A , Blanco Ricardo 
Published: December 2022

ObjectiveThe main study objective was to determine how giant cell arteritis (GCA) is diagnosed in our clinical practice and whether the EULAR recommendations have influenced the diagnostic procedures used.MethodsARTEritis of the Rheumatology Spanish Society -Sociedad Española de Reumatología (ARTESER) is a multicentre observational retrospective study conducted in 26 hospitals with support from the Spanish Society of Rheumatology. All patients diagnosed with GCA between 1 June 2013 and 29 March 2019 were included. The gold standard for the diagnosis of GCA was the judgement of the physician in charge, according to clinical criteria, supported by data available from laboratory tests, imaging studies (ultrasound, positron emission tomography (PET) and MRI/CT angiography) and temporal artery biopsy (TAB) when available.ResultsWe included 1675 patients with GCA (mean age±SD (76.9±8.1) years, 1178 women (70.3%)). Of these, 776 patients had a positive TAB (46.3%), 503 (30.0%) positive ultrasound, 245 positive PET (14.6%) and 64 positive MRI/CT angiography (3.8%). These percentages changed substantially over the study. From 2013 to 2019, the use of ultrasound in diagnosis grew from 25.8% to 52.9% and PET from 12.3% to 19.6%, while use of TAB decreased from 50.3% to 33.3%.ConclusionsBiopsy was the most widely used diagnostic test for confirming GCA, but use of imaging as a diagnostic tool has grown in recent years. Following publication of the 2018 EULAR recommendations, ultrasound has displaced biopsy as the first-line diagnostic test; TAB was performed in a third and PET in a fifth of cases.
A combination of omega-3 and exercise reduces experimental Achilles tendinopathy induced with a type-1 collagenase in rats
Authors: Gundogdu Gulsah , Tasci Seymanur Yilmaz , Gundogdu Koksal , Kapakin Kubra Asena Terim , Demirkaya Alper Kursat , Nalci Kemal Alp , Gundogdu Mustafa , Hacimuftuoglu Ahmet , Abd El-Aty A.M. 
Published: December 2022

This study aimed to evaluate the effectiveness of omega-3 supplementation with exercise in a collagenase-induced Achilles tendinopathy (AT) rat model. Experimental groups (healthy control (HC), AT, exercise (Ex), omega-3 (W), and Ex+W) were randomly allocated. After a week of adaptation, oral omega-3 was initiated for 8 weeks (5 days/week). The exercise groups performed treadmill running for 30 min/day (5 days/week, 20 m/min, 8 weeks) following one week of adaptation (10 m/min, 15 min/day). Matrix metalloproteinase-13 (MMP-13), interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and total antioxidant–oxidant status (TAS) levels were determined in serum samples. Tendon samples were obtained for biomechanical, histopathological, and immunohistochemical assessments. Ultimate tensile force, yield force, stiffness values, collagen type-I alpha 1 expression, and serum TAS significantly decreased ( P < 0.05) in AT vs. HC. These values and expression significantly increased in the Ex+W group vs. AT. Serum MMP-13, IL-1β, and TNF-α levels decreased in all treatment groups vs. AT. The most significant decrease was found in the Ex+W group ( P < 0.01). Histopathologically, the improvement in degeneration was statistically significant in the Ex+W group ( P < 0.05). Immunohistochemically, MMP-13, IL-1β, TNF-α, and nitric oxide synthase-2 expression was decreased in all treatment groups vs. AT. In conclusion, omega-3 and exercise might be recommended in AT patients.
Influence of permeability enhancers on the paracellular permeability of metformin hydrochloride and furosemide across Caco-2 cells
Authors: Gulsun Tugba , Izat Nihan , Sahin Selma 
Published: December 2022

Permeability enhancers can affect absorption of paracellularly transported drugs. This study aims to evaluate effects of permeability enhancers (chitosan, methyl- β -cyclodextrin, sodium caprate, sodium lauryl sulfate, etc.) on the permeability of paracellularly absorbed furosemide and metformin hydrochloride. Methyl thiazole tetrazolium bromide test was carried out to determine the drug concentrations in permeability study. Trans-epithelial electrical resistance (TEER) values determined to assess the integrity of tight junctions. Permeability enhancers were applied at different concentrations alone, in dual/triple combinations. Permeability was determined using human colorectal adenocarcinoma (Caco-2) cells (TEER > 400 Ω·cm2). Permeability enhancers have no significant effect (<2-fold; p > 0.05) on the permeability of furosemide (1.80 × 10−5 ± 4.55 × 10−7 cm/s); however, metformin permeability (1.36 × 10−5 ± 1.25 × 10−6 cm/s) increased significantly ( p < 0.05) with 0.3% and 0.5% ( w/v) chitosan (2.0- and 2.7-fold, respectively), 1% methyl- β -cyclodextrin ( w/v) (3.5-fold), 10 and 20 µmol/L sodium caprate (2.2- and 2.8-fold, respectively), and 0.012% sodium lauryl sulfate ( w/v) (1.9-fold). Furosemide permeability increased significantly ( p < 0.05) with chitosan-sodium lauryl sulfate combination (1.7-fold), and all triple combinations (1.4- to 1.9-fold). Chitosan containing dual/triple combinations resulted in significant increase ( p < 0.05) in metformin permeability (1.7 to 2.8-fold). All results indicated that absorption of furosemide and metformin can be improved by the combination of permeability enhancers. Therefore, it can be evaluated for the formulation of development strategies containing furosemide and metformin by the pharmaceutical industry.
Characterization of Boom Clay anisotropic THM behaviour based on two heating tests at different scales in the HADES URL
Authors: Chen Guangjing , Li Xiangling , Dizier Arnaud , Verstricht Jan , Sillen Xavier , Levasseur Severine 
Published: December 2022

Abstract

To examine the impact of the heat generated by high-level radioactive waste on Boom Clay, two heater tests have been launched in the HADES underground research facility: the small-scale ATLAS Heater Test and the large-scale PRACLAY Heater Test. The major objective of these tests is to confirm and refine the thermo-hydro-mechanical (THM) constitutive models and associated parameter values obtained from a laboratory characterization programme. This paper presents the observations from the ATLAS and PRACLAY heater tests and the combined numerical modelling of these tests. To characterize the excavation damaged zone in the clay around these tests, a mechanical model with a strain-dependent elastic modulus is introduced for the Boom Clay. The consistency between the observations from laboratory tests and
in-situ
tests and the outcomes from the numerical models strengthen the confidence in our understanding of the THM behaviour of Boom Clay. They also enabled us to validate the mechanical model and produce a set of anisotropic THM property values for both intact and damaged Boom Clay.
The role of the HADES URL in better understanding of the Boom Clay pore water geochemistry
Authors: De Craen Mieke , Moors Hugo , Honty Miroslav , Van Geet Maarten M. 
Published: December 2022

Abstract

When assessing a rock formation for its suitability as a potential host rock for the disposal of radioactive waste, knowledge about its pore water chemical composition is essential. When the HADES underground research laboratory became operational in the early 1980s, it offered the possibility of extracting pore water from Boom Clay. At the time, however, there was almost no experience of sampling pore water from deep clay formations. The low hydraulic conductivity of clays makes it difficult to extract pore water and the sampling process itself can induce changes in the observed chemical characteristics due to oxidation and re-equilibration with the ambient air. In the past decades, significant progress has been made in the techniques and protocols to sample and monitor pore water. The use of nitrogen instead of compressed air to drill boreholes and installing piezometers limited the disturbances induced by oxidation of the clay. Furthermore, an advanced system was developed to simultaneously sample pore water and dissolved gases and measure some key geochemical parameters such as pH, pCO
2
and redox potential under
in situ
conditions. This has resulted in a more reliable characterization of the Boom Clay pore water and a better understanding of perturbing processes such as oxidation.