bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of T2DM on right ventricular systolic dysfunction and interventricular interactions in patients with essential hypertension: evaluation using CMR tissue tracking
Authors: Li Xue-Ming , Yan Wei-Feng , Jiang Li , Shi Ke , Ren Yan , Han Pei-Lun , Peng Li-Qing , Guo Ying-Kun , Yang Zhi-Gang 
Published: November 2022

Abstract
Background
Previous studies reported that there was right ventricular (RV) systolic dysfunction in patients with hypertension. The aim of this study was to evaluate the impact of type 2 diabetes mellitus (T2DM) on RV systolic dysfunction and interventricular interactions using cardiac magnetic resonance feature tracking (CMR-FT) in patients with essential hypertension.

Methods and methods
Eighty-five hypertensive patients without T2DM [HTN(T2DM −)], 58 patients with T2DM [HTN(T2DM +)] and 49 normal controls were included in this study. The biventricular global radial, circumferential and longitudinal peak strains (GRS, GCS, GLS, respectively) and RV regional strains at the basal-, mid- and apical-cavity, were calculated with CMR-FT and compared among controls and different patient groups. Backward stepwise multivariable linear regression analyses were used to determine the effects of T2DM and left ventricular (LV) strains on RV strains.

Results
The biventricular GLS and RV apical longitudinal strain deteriorated significantly from controls, through HTN(T2DM-), to HTN(T2DM +) groups. RV middle longitudinal strain in patient groups were significantly reduced, and LV GRS and GCS and RV basal longitudinal strain were decreased in HTN(T2DM +) but preserved in HTN(T2DM-) group. Multivariable regression analyses adjusted for covariates demonstrated that T2DM was independently associated with LV strains (LV GRS: β = − 4.278, p = 0.004, model R2 = 0.285; GCS: β = 1.498, p = 0.006, model R2 = 0.363; GLS: β = 1.133, p = 0.007, model R2 = 0.372) and RV GLS (β = 1.454, p = 0.003, model R2 = 0.142) in hypertension. When T2DM and LV GLS were included in the multiple regression analysis, both T2DM and LV GLS (β = 0.977 and 0.362, p = 0.039 and < 0.001, model R2 = 0.224) were independently associated with RV GLS.

Conclusions
T2DM exacerbates RV systolic dysfunction in patients with hypertension, which may be associated with superimposed LV dysfunction by coexisting T2DM and suggests adverse interventricular interactions.
Multidisciplinary collaboration in diagnosis and treatment of neuroleptic malignant syndrome complicated with pneumonia: report of three cases
Authors: Zhao Huachang , Lu Sijia , Li Xiaoyan , Huang Panyun , Wang Hongming , Lu Fengmei 
Published: November 2022

Abstract
Background
Neuroleptic malignant syndrome (NMS) is a relatively rare and a potentially fatal syndrome. It is a serious complication associated with antipsychotic therapy. NMS is easily prone to pneumonia, rhabdomyolysis and other problems. However, the clinical features of NMS complicated with pneumonia remains largely unclear.

Case presentation
Here, we described three female adult patients of NMS complicated with pneumonia in our own hospital. The symptoms of the patients were controlled with antipsychotic drugs at admission. Symptoms such as high fever, high muscle tone, difficulty in eating, phlegm in the throat, anhelation, rhabdomyolysis and autonomic nervous dysfunction occurred 2 days after the treatment, which mainly concentrated within 1 week. In addition, they are all healed.

Conclusions
NMS is a rare and serious complication in psychiatric department, which is easy to be complicated with pneumonia and respiratory failure. Timely identification and early intervention could help achieve a good prognosis.
Genetic analysis of 55 cases with fetal skeletal dysplasia
Authors: Bai Ying , Sun Yue , Liu Ning , Wang Li , Jiao Zhihui , Hou Yaqin , Duan Huikun , Li Qianqian , Zhu Xiaofan , Meng Jingjing , Kong Xiangdong 
Published: November 2022

Abstract
Background
Fetal skeletal dysplasia (SD) is a common congenital disability comprising a complex group of skeletal disorders with substantial clinical and genetic heterogeneity. Many of these defects are detected prenatally using ultrasound (US). However, the diagnostic accuracy of the US is limited.

Methods
We recruited 55 unrelated fetuses with US-detected skeletal anomalies and performed sequential tests using copy number variation sequencing, targeted skeletal gene panel sequencing, or whole exome sequencing. The detected variants were validated using Sanger sequencing or multiplex ligation-dependent probe amplification. We conducted breakpoint analysis and structural modeling of variants possibly involved in fetal SD.

Results
A definitive diagnosis was achieved in 81.82% of affected fetuses (45/55). We identified chromosomal abnormalities in seven cases and 36 variants, of which 18 were novel pathogenic or likely pathogenic in 11 genes in 38 cases. De novo variants were identified in 27 cases (71.05%, 27/38), and one gonosomal mosaicism variant was found in the mother of one fetus. Our case examples demonstrated the high heterogeneity of fetal SDs and the rare fetal SD-associated challenges.

Conclusions
Careful clinical evaluation of fetuses with SD can guide appropriate molecular testing. Our study extends the SD-associated pathogenic variant spectrum and provides useful genetic counselling guidance and an accurate prenatal diagnosis strategy.
An algorithm based on the postoperative decrease of albumin (ΔAlb) to anticipate complications after liver surgery
Authors: Labgaa Ismail , Cano Luis , Mangana Orsalia , Joliat Gaëtan-Romain , Melloul Emmanuel , Halkic Nermin , Schäfer Markus , Vibert Eric , Demartines Nicolas , Golse Nicolas , Hübner Martin 
Published: November 2022

Abstract
Background
Perioperative decrease of albumin (ΔAlb) appeared as a promising predictor of complications after digestive surgery, but its role after liver surgery remains unclear. This study aimed to analyze whether and how ΔAlb can be used to predict complications after liver surgery.

Methods
A bicentric retrospective analysis of patients undergoing liver surgery (2010–2016) was performed, following TRIPOD guidelines. The preoperative and postoperative difference of albumin was calculated on POD 0 and defined as ΔAlb. Patients with any missing variable were excluded. The primary endpoint was overall complications according to the Clavien classification. A multiparametric algorithm based on ΔAlb was generated to optimize prediction performance.

Results
A total of 110 patients were analyzed. At least one complication occurred in 66 (60%) patients. Patients with and without complication showed a ΔAlb of 15.8 vs. 9.5 g/L (p<0.001). Area under ROC curve (AUC) of ΔAlb was 0.75 (p<0.01.). The ΔAlb-based algorithm showed an AUC of 0.84 (p<0.01), significantly improving performance (p=0.03). Multivariable analysis identified ΔAlb as independent predictor of complications (HR, 1.12; 95% CI, 1.01–1.07; p = 0.002).

Conclusions
ΔAlb appeared as a promising predictor independently associated with the risk of complication after liver surgery. The study presents a novel decision-tree based on ΔAlb to anticipate complications.
Circular RNA hsa_circ_0023404 promotes the proliferation, migration and invasion in endometrial cancer cells through regulating miR-217/MAPK1 axis
Authors: Chen Zhuoying , Huang Meixiu , You Jiaying , Lin Yanhua , Huang Qiaoyun , He Caiping 
Published: November 2022

Abstract
Background
Emerging studies indicated that circular RNA hsa_circ_ 0023404 and its target miR-217/MARK1 axis play a critical role in cancer progression such as non-small cell lung cancer and cervical cancer. However, the role of hsa_circ_0023404/miR-217/MARK1 involved in endometrial cancer (EC) was not investigated yet. The aim of this study is to investigate the functions of hsa_circ_0023404 in endometrial cancer (EC) and the potential molecular mechanism.

Methods
We used RT-qPCR and Western blot approach to detect the expressed levels of related genes in EC cell lines. Transfected siRNAs were applied to knockdown the level of related mRNA in cells. Cell proliferation by CCK-8 assay and colony formation assay were applied to detect cell proliferation. Transwell migration and invasion assay was for detecting the migration and invasion of the cells.

Results
RT-qPCR showed that the levels of hsa_circ_0023404 and MARK1 mRNA were upregulated, but mirR-217 was decreased in three endometrial cancer cell lines. Knockdown of hsa_circ_0023404 by siRNA markedly increased the level of miR-217 and reduced the proliferation of the Ishikawa cells. It also inhibited the cell migration and invasion. Anti-miR-217 can reverse the promoted proliferation, migrations and invasion of Ishikawa cells mediated by si-circ_0023404. si-MARK1 restored the inhibited cell proliferation, migration and invasion of the co-transfected Ishikawa cells with si- circ_0023404 and anti-miR-217.

Conclusion
hsa_circ_0023404 exerts a tumor-promoting role in endometrial cancer by regulating miR-217/MARK1 axis. hsa_circ_0023404 inhibit miR-217 as sponge which inhibit endometrial cancer cell growth and metastasis. MARK1 is downstream target of miR217 and upregulated by hsa_circ_ 0023404/miR-217 axis and involved in the endometrial cancer progression.
Binge-eating and sodium bicarbonate: a potent combination for gastric rupture in adults—two case reports and a review of literature
Authors: Han You Jin , Roy Susmit , Siau Ashley Maria Pei Ling , Majid Adeeb 
Published: November 2022

AbstractBackgroundDisordered eating behaviour including binge-eating often results in significant medical conditions, which are at times fatal. It can result in acute gastric dilatation which can lead to ischemic necrosis and stomach rupture. Dyspepsia and bloating are common symptoms following binge eating. Patients commonly use over-the-counter medications like sodium bicarbonate or home remedies for relief. However, in very rare, reported cases, sodium bicarbonate has been attributed to cause acute gastric dilatation and spontaneous gastric rupture instead.MethodsWe report two cases of spontaneous gastric rupture following consumption of sodium bicarbonate containing antacids after a large meal, and a review of the literature of similar cases.ResultsA total of 36 cases were identified. Approximately half of the cases (47.2%) were correlated with eating disorders, with higher prevalence in females (69%) and a very high mortality rate (41.6%). Amongst the 36 cases, sodium bicarbonate ingestion was associated with 10 cases. The lesser curvature (36.1%) and anterior wall (33.3%) are the most common sites of rupture. Associated causes include binge-eating, gas release from sodium bicarbonate, gastric content fermentation, proximal and distal outlet obstruction, and muscular atony.DiscussionSudden distension and impaired emptying mechanism of the stomach is necessary for spontaneous gastric rupture to occur. Acute gastric dilatation with perforation requires definitive surgical management. There should be a low threshold of suspicion for patients presenting with severe abdominal pain and abdominal distension following an episode of binge-eating. There is a need for patient education around the use of over-the-counter medications or home remedies.
Carpal tunnel syndrome in rheumatoid arthritis patients: the role of combined ultrasonographic and electrophysiological assessment
Authors: Mahmoud Wafaa , El-Naby Mona Mansour Hassab , Awad Ahmed Abdellatif 
Published: November 2022

Abstract
Background
Carpal tunnel syndrome (CTS) is known as one of the most common neurological extra-articular manifestations in rheumatoid arthritis (RA) patients. Studies on CTS in RA depend mostly on electrophysiological assessment. Few studies have used ultrasonography for evaluation of the local causes with much focus on wrist arthritis and tenosynovitis as the main cause of entrapment neuropathy of the median nerve in RA. The aim of our study is to assess the local causes of carpal tunnel syndrome in rheumatoid arthritis patients by ultrasonography and whether inflammatory or anomalous variations could affect decision-making and patient management.

Results
Carpal tunnel syndrome was diagnosed in 71 out of 74 examined RA wrists by nerve conduction studies (NCSs) and was categorized from minimal to severe according to Padua et al.’s (Ital J Neurol Sci 18:145–50, 1997) grading criteria. Median nerve CSA at the level of the carpal tunnel inlet and flattening ratio showed statistically significant relation with CTS severity. Bifid MN was found in 20 wrists (10 mild CTS wrists and 10 moderate CTS wrists), a persistent median artery was found in 4 wrists with moderate CTS, and an accessory muscle bundle was present in 3 wrists (2 mild CTS and 1 moderate CTS). The majority of the examined hands (85.1%) showed flexor tendon tenosynovitis at the wrist level and radio-carpal joint synovitis. The US7-joint score using GSUS7 & PDUS7 for synovitis, tenosynovitis and erosions showed significant relation with patients’ disease activity by DAS28 score. Significant relations between CTS severity and the following nerve conduction studies’ parameters, median nerve distal motor latency (DML), motor/sensory NCV, peak sensory latency, amplitude of SNAP, and median-radial latency difference test, were observed.

Conclusion
Synovial inflammation and local causes of median nerve compression such as bifid median nerve, persistent median artery, and accessory muscle bundle are collectively contributing factors in the etiology of carpal tunnel syndrome in rheumatoid arthritis patients. Ultrasonographic visualization of these inflammatory and anomalous variations enables early detection of CTS and highlights the possibility of non-arthritic-related causes. Using the 7-joint ultrasound (US7) score for assessment of synovitis, tenosynovitis, and erosions in rheumatoid arthritis patients is of valuable role in reflecting inflammation and its relation to the development of CTS in RA patients.
Impact of the COVID-19 Pandemic on Cancer Staging: An Analysis of Patients With Breast Cancer From a Community Practice in Brazil
Authors: Resende Cristiano A.A. , Fernandes Cruz Heloísa M. , Costa e Silva Matheus , Paes Rafael D. , Dienstmann Rodrigo , Barrios Carlos H.E. , Goncalves Aline C. , Cascelli Fanny G.A. , Souto Andreza K.B.A. , Oliveira Leandro C. , Reinert Tomás , Andrade Diocesio A.P. , Passos Mauro P. , Millen Eduardo C. , Zerwes Felipe , Moraes Paulo L. , Ferrari Bruno L. , Mano Max S. 
Published: November 2022

PURPOSE A nationwide lockdown was enforced in Brazil starting in March 2020 because of the COVID-19 pandemic when cancer screening activities were reduced. In this study, we evaluated the impact of the COVID-19 pandemic on breast cancer (BC) diagnosis. METHODS We extracted data from the medical records of patients age older than 18 years who were diagnosed with BC and started treatment or follow-up in private oncology institutions in Brazil between 2018 and 2021. The primary objective was to compare the stage distribution during the COVID-19 pandemic (2020-2021) with a historical prepandemic control cohort (2018-2019). Early BC was defined as stage I-II and advanced disease as stage IV. RESULTS We collected data for 11,753 patients with an initial diagnosis of BC, with 6,493 patients in the pandemic (2020-2021) and 5,260 patients in the prepandemic period (2018-2019). We observed a lower prevalence of early-stage BC (63.6% v 68.4%) and a higher prevalence of advanced-stage BC (16.9 v 12.7%), after the onset of the pandemic (both P < .01). This pattern was similar for both estrogen receptor–positive/human epidermal growth factor receptor 2–negative and human epidermal growth factor receptor 2–positive tumors: significantly decreased in the early stage from 69% to 67% and 68% to 58%, respectively, and a considerable increase in advanced-stage disease from 13% to 15% and 13% to 20%, respectively. For triple-negative BC, there was a significantly higher percentage of patients with advanced-stage disease during the pandemic (17% v 11%). Overall, age 50 years or older and postmenopausal status were associated with a greater risk of advanced stage at diagnosis during the pandemic period. CONCLUSION We observed a substantial increase in the number of cases of advanced-stage BC in Brazil during the COVID-19 pandemic.
Gut homeostasis at a glance
Authors: Choo Jieun , Glisovic Neda , Matic Vignjevic Danijela 
Published: November 2022

ABSTRACT
The intestine, a rapidly self-renewing organ, is part of the gastrointestinal system. Its major roles are to absorb food-derived nutrients and water, process waste and act as a barrier against potentially harmful substances. Here, we will give a brief overview of the primary functions of the intestine, its structure and the luminal gradients along its length. We will discuss the dynamics of the intestinal epithelium, its turnover, and the maintenance of homeostasis. Finally, we will focus on the characteristics and functions of intestinal mesenchymal and immune cells. In this Cell Science at a Glance article and the accompanying poster, we aim to present the most recent information about gut cell biology and physiology, providing a resource for further exploration.
Figurative Language in the Broken Wings by Kahlil Gibran: An Analysis of Language Style as Stylistic Effect
Authors: Fitria Tira Nur 
Published: November 2022

The objective of this research is to find out the figurative languages in the Broken Wings by Kahlil Gibran. This research is descriptive qualitative. The data was taken from Kahlil Gibran’s novel entitled “The Broken Wings”. The researcher analyzes the data based on Abrams’s theory (1999) about figurative language. The result analysis shows that Based on table 9 above, shows there are several types of figurative language in “The Broken Wings” by Kahlil Gibran. 292 data contains figurative language in 8 types of figurative language including simile, personification, metaphor, synecdoche, hyperbole, paradox, symbol, and proverb. In a simile, there are 128 data (43.8 %). In personification, there are 34 data (11.6 %). In metaphor, there are 33 data (11.3 %). In synecdoche, there are 30 data (10.3 %). In hyperbole, there are 25 data (8.6 %). In a paradox, there are 22 data (7.5 %). In symbol, there are 13 data (4.5 %). In the proverb, there are 7 data (2.4 %). It shows that the most dominant type of figurative language in “The Broken Wings” by Kahlil Gibran is simile as 128 data or 43.8 %. The novel Broken Wings by Kahlil Gibran is a romantic literary novel that tells the fate of Gibran's love story for a Lebanese girl named Selma Karamy. The writing of this novel is very light and easy to read and the way he writes it makes us immersed in the situation of the love story. The style of language used by the author in this novel is very distinctive. The author provides proof that his love story wrapped in romance is written in beautiful and interesting language to the readers.
Semantic Negation on Verbal Clauses with Verbs of Imminence in Saudi Arabic Varieties
Authors: Alzahrani Salih 
Published: November 2022

Negation in languages is a phenomenon, which receives researchers' attention for a long period. Negation occurs on different type of clauses by which it shows to have morphological and syntactic changes over the structure of words, phrases and sentences. Verbs of imminenceare used sometimes to denote negation in verbal clauses in Arabic. ka:d is one of those verbs which carries the negation of the clause without using any negative particles. Saudi dialects use the verb baʁa to perform the same function. This paper discusses baʁa in verbal clauses illustrating its syntactic and semantic impact on the structure of the clauses. It requires the imperfective form of the verb to follow. Negating a clause, with the only negative particles ma: and/or la:, does not carry the negative sense because it is delivered through the use of baʁa. Thus, the negation of verbs of imminence does not require the presence of any negative particles. Otherwise, the positive meaning is delivered.
Judicialização do direito à saúde de usuários do SUS em Feira de Santana-BA: análise de decisões judiciais em segunda instancia
Authors: Da Silva Deutt Ferreira Mariana , Iraildes Andrade Juliano  
Published: November 2022

A universalidade do atendimento, igualdade e integralidade são os três princípios do Sistema Único de Saúde (SUS) que fundamentam as condições para a promoção, proteção e recuperação da saúde, segundo a Lei Orgânica da Saúde, no 8.080/1990, a qual também rege a organização e funcionamento dos serviços (Gontijo, 2010).
Reflexiones sobre el primer caso de triple filiación desde el nacimiento en Argentina. Por qué es importante establecer diferencias con la adopción y la subrogación del embarazo
Authors: Cristina Mariana 
Published: November 2022

El presente artículo tiene el propósito de reflexionar sobre un reciente caso de triple filiación desde el nacimiento en Argentina que constituye una nueva forma de coparentalidad. Para ello, en primer lugar, realizo una descripción de los hechos y la sentencia. En segundo lugar, refiero que los feminismos y los movimientos por la diversidad han colaborado en comprensiones y prácticas más respetuosas y dinámicas de la institución familiar en clara oposición al neoconservadurismo. Luego planteo que la defensa de dicho dinamismo familiar fundado no debiera llevarnos a defender cualquier camino para la consecución del proyecto familiar, puntualmente en el caso de varones solos o en pareja. Por ello, diferencio los modos que usualmente tienen para alcanzar la paternidad con el objetivo de mostrar cómo la coparentalidad y la adopción son moralmente aceptables mientras que la subrogación del embarazo es cuestionable éticamente.
In-school adolescents’ loneliness, social support, and suicidal ideation in sub-Saharan Africa: Leveraging Global School Health data to advance mental health focus in the region
Authors: Aboagye Richard Gyan , Ahinkorah Bright Opoku , Seidu Abdul-Aziz , Okyere Joshua , Frimpong James Boadu , Kumar Manasi 
Published: November 2022

Introduction
Adolescent and youth mental health problems are increasingly becoming an area of concern in global health. Young people in sub-Saharan Africa experience significant adversities and systemic challenges despite technological advancements and demographic transition that the region is experiencing. We examined the nexus between experiences of loneliness, low social support, and presence of suicidal ideation among in-school adolescents in sub-Saharan Africa.

Method
A total of 19,119 in-school adolescents from eight countries in sub-Saharan Africa were included in this study. Suicidal ideation was the main outcome variable and loneliness, and social support were the explanatory variables. Percentages were used to summarise the prevalence of suicidal ideation, loneliness, and social support among the in-school adolescents. A multivariable binary logistic regression analysis was later used to determine the association between suicidal ideation and the explanatory variables and covariates using Stata v16. Four models were tested using the regression analysis. We presented the regression results using adjusted odds ratios (aOR), with their respective 95% confidence intervals (CIs).

Results
Overall, the past year prevalence of loneliness, peer support, one or more close friends, and suicidal ideation were 10%, 33.4%, 90.1%, and 14.5%, respectively. In-school adolescents who felt lonely (aOR = 1.88, 95% CI = 1.69, 2.09) were more likely to experience suicidal ideation. However, those who received peer support (aOR = 0.89, 95% CI = 0.82, 0.97) and had one or more close friends (aOR = 0.77, 95% CI = 0.68, 0.86) were less likely to experience suicidal ideation.

Conclusion
These results point to the significant roles of loneliness, and lack of social support, in understanding suicidal ideations. Countries in sub-Saharan Africa need to improve child and adolescent mental health policies and programmes to respond to these risk factors and mental health challenges. Programmes with a differential focus on the needs of males and females, younger and older adolescents will be important in the future.