bluuebunny/crossref_metadata_2025_split huggingface dataset:
Der Porcine Respiratory Disease Complex (PRDC) – eine klinische Übersicht
Authors: Eddicks Matthias , Eddicks Lina , Stadler Julia , Hermanns Walter , Ritzmann Mathias 
Published: February 2022

ZusammenfassungDer Porcine Respiratory Disease Complex (PRDC) beschreibt eine klinische Kondition, die sich in Form einer häufig therapieresistenten Atemwegsinfektion bei Mastschweinen manifestiert. Die multifaktorielle Ätiologie beinhaltet infektiöse und nicht infektiöse Faktoren. Bei Entstehung und Verlauf des PRDC spielen neben Management und Hygiene v. a. virale und bakterielle Erreger eine bedeutende Rolle. Das Virus des Porzinen Reproduktiven und Respiratorischen Syndroms (PRRSV), das porzine Circovirus Typ 2 (PCV2), Influenza-A-Virus (IAV) und Mycoplasma (M.) hyopneumoniae stellen die relevantesten Erreger dar. Das klinische Bild und die zugrundeliegenden pathomorphologischen Veränderungen können je nach Erregerbeteiligung variieren. Die Komplexität des PRDC erschwert die Diagnose und auch die Prävention auf Bestandsebene. Der Übersichtsartikel gibt einen Einblick in die Pathomorphologie, Pathogenese sowie Inter-Erreger-Interaktionen und zielt darauf ab, praktizierende Tierärztinnen und Tierärzte bei der Diagnose, Befundinterpretation und Prävention des PRDC zu unterstützen.
Erfassung und Verarbeitung von Stress bei ärztlichem Personal in Krankenhäusern der Grund- und Schwerpunktversorgung in Deutschland im zeitlichen Verlauf der COVID-19-Pandemie
Authors: Reis Daniela , Scheiderer Marie-Léne , Kis Bernhard , Längler Alfred , Martin David , Scharbrodt Wolfram , Schmidt Peter , Lutz Gabriele , Müller Helge , Edelhäuser Friedrich , Matthes Harald , Sieberer Marcel , Vagedes Jan , Wintzer Christian , Fricke Oliver 
Published: February 2022

ZUSAMMENFASSUNG
Hintergrund Verschiedene Studien berichten über das Stresserleben von Krankenhausmitarbeitern während der COVID-19-Pandemie, aber auch vor der Pandemie fühlten sich viele ärztliche Klinikmitarbeiter durch ein hohes Arbeitspensum oder unklare Vorgaben emotional erschöpft.
Methoden Kognitive Bewertungen und das Stresserleben von ärztlichem Krankenhauspersonal aus 6 Kliniken im zeitlichen Verlauf der COVID-19-Pandemie wurden ausgewertet. Neben der deutschsprachigen Version des „Stress Appraisal Measure“ (SAM) wurden die COVID-19-Patientenbelegungen und die relative Bettenbelegung erfragt; Korrelationen im Quer- und Längsschnitt wurden berechnet.
Ergebnisse Teilnehmer t1: 170, t2: 55, t3: 47 Ärzte. Obwohl keine Erfahrung mit einer solchen Pandemie vorhanden war, waren die SAM-Mittelwerte nicht auffallend unterschiedlich im Zeitverlauf. Höhere lokale Neuinfektionen gingen nicht einher mit einer erhöhten Bewertung, die Situation als bedrohlich oder stressend zu erleben. Hohe positive Korrelationen der gleichen SAM-Unterskalen im Längsschnitt könnten ein Hinweis sein für ein zeitstabiles Persönlichkeitsmerkmal, welches die kognitiven Bewertungen beeinflusst.
Schlussfolgerung Die Ergebnisse geben erste Hinweise, dass das ärztliche Personal eine gute Strategie zur Bewältigung des pandemiebedingten Stresserlebens hatte. Eine differenziertere Analyse des Stresserlebens von medizinischem Personal im Allgemeinen, und nicht nur zu besonderen Zeiten der Pandemie, könnte zukünftig vorgenommen werden.
Growth and Pubertal Features in a Cohort of 83 Patients with
Osteogenesis Imperfecta
Authors: Öztürk Ayşe Pınar , Dudaklı Aslı , Özturan Esin Karakılıç , Poyrazoğlu Şükran , Baş Firdevs , Darendeliler Feyza 
Published: February 2022

Abstract
Background Osteogenesis imperfecta (OI) is a genetic disease characterized
by fragile bones and variable short stature.
Method We performed a retrospective cohort study to evaluate demographic
data, clinical findings, growth and pubertal characteristics, and medical
treatment of 83 OI patients.
Results 83 (31 female/52 male) patients were enrolled in the
study. The median follow-up duration was 4.7 (0.6–17.7) years. 51 out of
83 patients (61.4%) received bisphosphonate therapy. The median Z-score
of the bone mineral density improved in patients with OI-I and OI-III with the
treatment. During follow-up, height-SDS significantly increased in both OI-I and
OI-III on treatment; however, final adult height SDS of patients did not
improve. The frequency of overweight and obesity was found to be increased at
the last evaluation compared to the admission. The rate of precocious puberty
(PP) and early puberty (EP) were 20 and 10% in girls, and they were 15.7
and 47.3% in boys, respectively.
Conclusion Reduced growth, significant weight gain over time due to
impaired mobility, and high frequency of PP/EP require effective
interventions to improve mobility and functional parameters as early as possible
in children with OI.
Imaging of Hockey-related Injuries of the Head, Neck, and Body
Authors: Holmes R. Davis , Walsh John P. , Yan Yet Y. , Mallinson Paul I. , Andrews Gordon T. , Munk Peter L. , Ouellette Hugue A. 
Published: February 2022

AbstractHockey is a demanding contact sport with growing popularity around the world. This article is part of a review series in this issue of Seminars in Musculoskeletal Radiology that summarizes epidemiological research on the patterns of ice hockey injuries as well as provides pictorial examples for a radiologist's perspective. We focus on non-extremity pathologies which encompass many of the most devastating injuries of hockey, namely those involving the head, neck, face, spine, and body.
Musculoskeletal Injuries in Cross-Country Skiing
Authors: Lemos Diego F. , Geeslin Matthew G. , Kanner Christopher , Lach Mark E. , Pedersen Roar R. 
Published: February 2022

AbstractCross-country skiing, one of the oldest forms of skiing, is enjoyed widely as a recreational activity and as a competitive sport. It is practiced in regions with snow-covered landscapes, particularly in the Nordic countries and with increasing popularity in non-Nordic countries of Europe as well as in the United States, Canada, Australia, and New Zealand, among others. Cross-country skiing is a fairly safe activity, and historically the risk of injury has been relatively low. However, advances in equipment development, together with increasing speeds, more demanding trails, and growing numbers of participants, have all contributed to a larger report of injuries, although still comparatively low versus other skiing modalities. Injuries in cross-country skiing can occur either after a single traumatic event or in the setting of chronic repetitive microtrauma (i.e., overuse injuries).
Análise comparativa do tratamento de lesões cutâneas dos membros inferiores com retalho sural versus retalho propeller
Authors: Tenezaca Katherine V. , Silva Gustavo Bersani , Iamaguchi Raquel Bernardelli , Rezende Marcelo Rosa de , Wei Teng Hsiang , Cho Álvaro B. 
Published: February 2022

Resumo
Objetivo O objetivo do presente estudo foi comparar prospectivamente os retalhos sural e propeller para cobertura de partes moles da extremidade inferior. Foram avaliadas as seguintes variáveis: incidência de perda total ou parcial do retalho e morbidade da área doadora (fechamento primário versus enxerto de pele).
Métodos Análise prospectiva e randomizada de dados coletados de todos os pacientes apresentando defeitos em tecidos moles da extremidade distal da perna e do retropé submetidos aos retalhos em questão.
Resultados Foram avaliados 24 pacientes com idades entre 4 e 60 anos, entre 2011 e 2017. Cobertura completa foi obtida em 22 dos 24 pacientes (91,6%) e observamos falha em 2 retalhos (8,4%). O retalho sural, sendo a opção mais popular, continua a representar uma alternativa segura e versátil para defeitos cutâneos do terço distal da perna e da região do calcanhar. O retalho propeller, da mesma maneira, mostrou-se uma opção comparável para o tratamento destas lesões desafiadoras.
Conclusão Os retalhos sural e propeller são boas opções para a cobertura de partes moles da extremidade inferior, demostrando baixas taxas de complicações como perda parcial ou total do retalho.
Comparação do tratamento artroscópico de ruptura do manguito rotador em pacientes com menos de 55 anos versus pacientes com mais de 65 anos
Authors: Storti Thiago Medeiros , Pontes Júnior Antônio Carlos , Simionatto João Eduardo , Simionatto Carolina , Faria Rafael Salomon Silva , Paniago Alexandre Firmino 
Published: February 2022

Resumo
Objetivo Avaliar os pacientes submetidos a reparo artroscópico do manguito rotador (MR) comparando os resultados de força muscular, funcionais e de dor obtidos em 2 grupos distintos: de pacientes < 55 anos (G55) e em pacientes > 65 anos (G65).
Métodos A coleta de dados foi realizada com 63 participantes (29 pacientes < 55 anos e 34 > 65 anos), em 2 momentos, analisando: A) características demográficas, cirúrgicas e das lesões de MR; B) variáveis funcionais, força muscular e dor.
Resultados Foram observados maiores níveis de na força de elevação anterior, rotação lateral e rotação medial do ombro operado no grupo G55. Porém, quando avaliada a diferença entre estas forças do ombro operado e do ombro contralateral, não se observou diferença significativa entre os grupos. As demais variáveis de função e dor foram similares (p > 0,05). Também não houve diferença entre os grupos nos escores University of California, Los Angeles (UCLA, na sigla em inglês) (p = 0,56) e Constant (p = 0,99).
Conclusão O reparo artroscópico do MR em pacientes mais velhos, ativos e selecionados pode obter melhora funcional e de qualidade de vida similar ao realizado em pacientes mais jovens.
Como escolher entre as abordagens transolecraniana e por reflexão do tríceps para tratar fraturas distais do úmero em adultos: Um estudo prospectivo
Authors: Jamoh Kalom , Tonk Gyneshwar 
Published: February 2022

Resumo
Objetivo Escolher uma abordagem posterior adequada para fraturas distais do úmero em adultos.
Métodos Cinquenta pacientes com fraturas distais do úmero foram analisados prospectivamente. As fraturas foram classificadas por meio da classificação Arbeitsgemeinschaft für Osteosynthesefragen/Orthopaedic Trauma Association (AO/OTA). Os pacientes foram divididos em grupo A e grupo B. A osteotomia olecraniana (abordagem transolecraniana) foi realizada em 30 pacientes, e a abordagem por reflexão do tríceps foi usada em 20 pacientes. Os resultados funcionais foram avaliados por meio do Mayo Elbow Performance Score (MEPS) e do questionário Disabilities of the Arm, Shoulder and Hand (DASH).
Resultados O tempo médio da cirurgia foi de 92,62 ± 8,73 minutos para o grupo A, e de 78,63 ± 7,02 minutos para o grupo B (p < 0,01) e a média da perda sanguínea foi de 222,78 ± 34,93 mL no grupo A, e de 121,61 ± 19,85 mL no grupo B (p < 0,01), os quais foram estatisticamente significativos. As pontuações médias no MEPS e no DASH de ambos os grupos foram consideradas insignificantes. Complicações como infecção, neurapraxia e irritação de tecidos moles foram mais observadas no grupo A.
Conclusão A abordagem por reflexão do tríceps resulta em menor tempo de operação, menor perda de sangue, e baixas taxas de complicações, e a osteotomia olecraniana proporciona uma melhor precisão da redução articular. Mas não houve diferença significativa entre os dois grupos em termos do resultado funcional. Por isso, propusemos uma nova classificação, que é uma modificação da classificação AO/OTA: o tipo 1 inclui os graus AO 13A a C2 (excluído o B3); e o tipo 2, AO 13C3. Para fraturas do tipo 1, a abordagem por reflexão do tríceps pode ser considerada, e , para as fraturas do tipo 2, a osteotomia olecraniana.
Uma comparação entre a medição e a classificação da ruptura do manguito rotador no pré-operatório e no intraoperatório
Authors: Gill Karl Peter , Bateman Marcus , Mazuquin Bruno , Littlewood Chris 
Published: February 2022

Resumo
Objetivo Avaliar a concordância no tamanho de ruptura obtido por imagem pré-operatória e por medição intraoperatória, e determinar a precisão da imagem pré-operatória na classificação do tamanho da ruptura e na identificação de rupturas em cada tendão do manguito rotador.
Métodos Os dados de 44 pacientes recrutados para um ensaio controlado randomizado foram revisados retrospectivamente. O tamanho e a localização do manguito rotador foram confirmados por ultrassom ou ressonância magnética préoperatórios, e avaliados durante a cirurgia. Um teste t e o gráfico de Bland e Altman foram usados para determinar a concordância entre as medições pré-operatória e intraoperatória. Sensibilidade, especificidade, valor preditivo positivo (VPP) e valor preditivo negativo (VPN) foram calculados para o tamanho do rompimento e o envolvimento do tendão do manguito rotador.
Resultados Houve boa concordância para medidas de tamanho da ruptura (91%) e classificação (89%) pré-operatória e durante a cirurgia. Ao classificar o tamanho da ruptura, a sensibilidade e o VPP foram elevados para rupturas de tamanho médio (100%), e menor para rupturas grandes (75%), o que indica que todas as rupturas de tamanho médio, mas nem todas as grandes, foram identificadas pré-operatoriamente. Para a identificação de rupturas, a sensibilidade pré-operatória e o VPP foram maiores para o supraespinal (84%), com sensibilidade e VPP progressivamente menores para o infraespinal (57%), o subescapular (17%), e o redondo menor (0%).
Conclusões Por meio da imagem pré-operatória, pode-se medir ou classificar com precisão o tamanho da ruptura. Quando há discordância, não está claro se o tamanho da ruptura é subestimado no exame ou superestimado durante a cirurgia. A alta sensibilidade demonstra que uma ruptura do supraespinal é geralmente detectada por escaneamento. As sensibilidades mais baixas para o infraespinal e o subescapular indicam que a identificação de rupturas nestes tendões é menos precisa.
Impact of Carbohydrate Counting Method during Pregnancy in Women with Pregestational Diabetes Mellitus: A Controlled Clinical Trial
Authors: Oliveira Larissa Mello de , Belfort Gabriella Pinto , Padilha Patricia de Carvalho , Rosado Eliane Lopes , Silva Letícia Barbosa Gabriel da , Fagherazzi Sanmira , Zajdenverg Lenita , Zagury Roberto Luís , Saunders Claudia 
Published: February 2022

Abstract
Objective To evaluate the effect of the carbohydrate counting method (CCM) on glycemic control, maternal, and perinatal outcomes of pregnant women with pregestational diabetes mellitus (DM).
Methods Nonrandomized controlled clinical trial performed with 89 pregnant women who had pregestational DM and received prenatal care in a public hospital in Rio de Janeiro, state of Rio de Janeiro, Brazil, between 2009 and 2014, subdivided into historic control group and intervention group, not simultaneous. The intervention group (n = 51) received nutritional guidance from the carbohydrate counting method (CCM), and the historical control group (n = 38), was guided by the traditional method (TM). The Mann-Whitney test or the Wilcoxon test were used to compare intra- and intergroup outcomes and analysis of variance (ANOVA) for repeated measures, corrected by the Bonferroni post-hoc test, was used to assess postprandial blood glucose.
Results Only the CCM group showed a reduction in fasting blood glucose. Postprandial blood glucose decreased in the 2nd (p = 0.00) and 3rd (p = 0.00) gestational trimester in the CCM group, while in the TM group the reduction occurred only in the 2nd trimester (p = 0.015). For perinatal outcomes and hypertensive disorders of pregnancy, there were no differences between groups. Cesarean delivery was performed in 82% of the pregnant women and was associated with hypertensive disorders (gestational hypertension or pre-eclampsia; p = 0.047).
Conclusion Both methods of nutritional guidance contributed to the reduction of postprandial glycemia of women and no differences were observed for maternal and perinatal outcomes. However, CCM had a better effect on postprandial glycemia and only this method contributed to reducing fasting blood glucose throughout the intervention.
ReBEC Clinical Trials Database The present study was registered in the ReBEC Clinical Trials Database (Registro Brasileiro de Ensaios Clínicos, number RBR-524z9n).
Indocyanine Green (ICG)-Guided Identification of Hypermetabolic Pancreatic Nodules in Focal Congenital Hyperinsulinism: A Case Report in a 3-Month-Old Infant
Authors: Delgado-Miguel Carlos , Muñoz-Serrano Antonio , Moratilla Lucas , Sarmiento María del Carmen , Miguel-Ferrero Miriam , Leal Nuria , Barrena Saturnino , Martínez Leopoldo 
Published: February 2022

AbstractIndocyanine green (ICG)-guided near-infrared fluorescence has been recently adopted in pediatric surgery, although its use in the treatment of congenital hyperinsulinism has not been reported. We present a case of focal congenital hyperinsulinism in which ICG-navigation with ICG was used during surgical treatment. A 3-month-old infant was referred to our institution from a peripheral hospital for episodes of persistent hypoglycemia since birth, with no response to intravenous treatment with diazoxide, octreotide, or hydrochlorothiazide. An abdominal positron emission tomography-computed tomography scan showed a hypermetabolic nodule in the proximal portion of the body of the pancreas, compatible with focal congenital hyperinsulinism. A heterozygous mutation in the ABCC gene (Ala1516Glyfs*19) frameshift type inherited from the father was identified, which supported this diagnosis. Laparoscopy-assisted surgery was performed with ICG-guided near-infrared fluorescence, with intravenous injection of 16 mg ICG (2 mg/mg), which allowed localization of the focal lesion in the body of the pancreas. The lesion was resected with bipolar electrocautery and intraoperative histological study confirmed complete resection. Plasma glucose values normalized 6 hours after surgery and the patient was discharged 5 days later. In conclusion, the use of ICG in the treatment of congenital hyperinsulinism helps to identify hypermetabolic pancreatic nodules, decreasing the likelihood of incomplete resection.
Antibiotic Resistance Pattern in Pediatric Deep Neck Space Infection
Authors: Kharel Bijaya , Shahi Kapil , Gurung Urmila 
Published: February 2022

Abstract
Introduction Neck space infection in the pediatric age group is common but can be life-threatening if not diagnosed properly. Since it is a polymicrobial disease, antibiotic usage should be guided by culture sensitivity pattern.
Objectives To assess the microbiology, antibiotic resistance pattern and the outcome of the medical and surgical management of deep neck space infection in children.
Methods This was a prospective study of children admitted for management of neck space infection from August 2017 to August 2018. The age, gender, organisms isolated, sensitivity and resistance to antibiotics, length of hospital stay, complications, and recurrence were noted. The descriptive data were analyzed.
Results Out of 108 cases, there were 51 males (47.2%) and 57 females (52.8%) ranging from 1 month to 15 years, with a mean age of 5.32 +/− 4.35 years. The mean period of hospitalization was 6.98 days. Staphylococcus aureus was the most common organism isolated with less coagulase-negative staphylococci and streptococci. Clindamycin was the most sensitive drug (82.35%) followed by vancomycin and cloxcillin, while amoxicillin/ampicillin, a commonly used drug, was the least sensitive (20.58%). The abscess recurrence rate was 9.28%. The outcomes of either medical treatment or a combined medical or surgical treatment in properly selected cases were comparable.
Conclusion Clindamycin or cloxacillin can be used as a first-line option for neck infection in children. Ampicillin/amoxicillin alone has a small role in neck abscess because of high resistance to this type of antibiotic.
Bivalent recognition of fatty acyl-CoA by a human integral membrane palmitoyltransferase
Authors: Lee Chul-Jin , Stix Robyn , Rana Mitra S. , Shikwana Flowreen , Murphy R. Elliot , Ghirlando Rodolfo , Faraldo-Gómez José D. , Banerjee Anirban 
Published: February 2022

Significance
Protein palmitoylation is one of the most highly abundant protein modifications, through which long-chain fatty acids get attached to cysteines by a thioester linkage. It plays critically important roles in growth signaling, the organization of synaptic receptors, and the regulation of ion channel function. Yet the molecular mechanism of the DHHC family of integral membrane enzymes that catalyze this modification remains poorly understood. Here, we present the structure of a precatalytic complex of human DHHC20 with palmitoyl CoA. Together with the accompanying functional data, the structure shows how a bivalent recognition of palmitoyl CoA by the DHHC enzyme, simultaneously at both the fatty acyl group and the CoA headgroup, is essential for catalytic chemistry to proceed.
Phonetic listen-and-repeat training alters 6–7-year-old children’s non-native vowel contrast production after one
training session
Authors: Immonen Katja , Alku Paavo , Peltola Maija S. 
Published: February 2022

Abstract
The present study investigated children’s ability to learn to produce a non-native vowel contrast through a
listen-and-repeat training method that is traditionally used in foreign language classrooms. Sixteen Finnish preschoolers (aged
6–7 years) were tested. The stimuli were two semi-synthetic pseudo words with the familiar vowel /y/ and the novel vowel /ʉ/
embedded in the first syllable. The procedure included four training and four recording sessions on two consecutive days. The
vowels produced by the children were acoustically analyzed to obtain the average values of the first and second formant. The
results showed that the participants changed their production of /ʉ/ towards the acoustic model after the first training and the
change remained throughout the experiment. Our findings suggest 6–7-year-old children learn to produce a non-native vowel contrast
even with limited L2 sound exposure in a listen-and-repeat training setting.
Moderators of the coach leadership and athlete motivation relationship
Authors: López de Subijana Cristina , Martin Luc J. , McGuire Cailie S. , Côté Jean 
Published: February 2022

ABSTRACTThe purpose of this study was to determine whether the relationship between coach leadership and athlete motivation was moderated by age, gender, competition level, and seasons spent with a coach. This study involved data from two previous studies that explored this relationship yet provides a novel perspective through the lens of important moderators. Three‐hundred and three athletes (M age = 17.6 years; SD = 3.20; 49.7% women and 50.3% men) responded to questionnaires pertaining to their coaches’ leadership behaviours and their own sport motivation. Multiple regression analyses using moderators were conducted. Age, competition level, and seasons spent with the coach significantly moderated the relationships of interest. Coach transformational leadership predicted intrinsic and extrinsic motivation to a greater extent when athletes were younger than 20.8 and 18.2 years of age, respectively. Further, coach transactional leadership predicted intrinsic and extrinsic motivation to a greater extent when athletes had trained for more than two seasons with their coach. Results emphasize the need to consider athlete characteristics from both research and practitioner perspectives. Herein, we advocate for increased awareness amongst key sport stakeholders on the influence that a coach can have on younger athletes’ motivation and the importance of developing coach‐athlete relationships over time.