bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fetal Reduction Could Improve but Not Completely Reverse the Pregnancy Outcomes of Multiple Pregnancies: Experience From a Single Center
Authors: Yimin Zhu , Minyue Tang , Yanling Fu , Huanmiao Yan , Saijun Sun , Qingfang Li , Xiaoling Hu , Lanfeng Xing 
Published: June 2022

ObjectiveTo investigate the effectiveness and limitations of multifetal pregnancy reduction (MFPR) on the improvement of pregnancy outcomes of triplet or twin pregnancies conceived by in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).MethodsWe performed a cohort study of women undergoing IVF or ICSI from 2002–2016 in reproductive center, women’s hospital, Zhejiang University School of Medicine. The cohort included 502 women who underwent MFPR and 9641 non-reduced women. Pregnancy outcomes were gestational age (GA) at delivery, pregnancy loss, preterm delivery, low birth weight (LBW), very low birth weight (VLBW), and small for gestational age (SGA). Multiple linear regression and logistic regression models were used to compare pregnancy outcomes between groups.ResultsTriplets reduced to singletons had a longer median GA (39.07 vs 37.00, P&lt;0.001), and lower rates of LBW (8.9% vs 53.2%, P&lt;0.001) and SGA (17.8% vs 44.7%, P=0.001) than triplets reduced to twins, with a similar pregnancy loss rate (6.7% vs 6.6%, P=0.701). Twins reduced to singletons had a comparable pregnancy loss rate (4.8% vs. 6.5%, P=0.40), a longer median GA (38.79 vs. 37.00, P&lt;0.001), and lower rates of LBW (13.5% vs. 47.0%, P&lt;0.001) and SGA (13.5% vs. 39.6%, P&lt;0.001) than primary twins. Triplets reduced to twins had higher rates of LBW (53.2% vs. 47.0%, P=0.028) and SGA (44.7% vs. 39.6%, P=0.040) than primary twins, with a similar pregnancy loss rate (6.6% vs. 6.5%, P=0.877). Singletons reduced from triplets/twins had higher rates of preterm delivery (15.8% vs. 7.3%, P&lt;0.001), LBW (12.3% vs. 4.32%, P&lt;0.001), VLBW (2.3% vs. 0.4%, P=0.002), and SGA (14.6% vs.6.6%, P&lt;0.001) than primary singletons, with a comparable pregnancy loss rate (5.3% vs. 5.4%, P=0.671).ConclusionsThis study suggests that the pregnancy loss rate is similar between reduction and non-reduction groups. MFPR improves pregnancy outcomes, including the risk of preterm delivery, LBW, and SGA, but still could not completely reverse the adverse pregnancy outcomes of multiple pregnancies.
Effects of Precursor Structure on First-Generation Photo-Oxidation Organic Aerosol Formation
Authors: Sofio D. , Long D. , Kohls T. , Kunz J. , Wentzel M. , Hanson D. 
Published: June 2022

The effect of precursor molecular structural features on secondary organic aerosol (SOA) growth was investigated for a number of precursor functional groups. SOA yields were determined for straight chain alkanes, some oxygenated, up to highly functionalized hydrocarbons, the largest being β-caryophyllene. Organic SOA yield was determined by comparing to standard particle size changes with SO2 in a photolytic flow reactor. SOA formation was initiated with OH radicals from HONO photolysis and continued with NO and NO2 present at single-digit nmol/mol levels. Seed particles of ∼10 nm diameter grew by condensation of SOA material and growth was monitored with a nanoparticle sizing system. Cyclic compounds dominate as the highest SOA yielding structural feature, followed by C-10 species with double bonds, with linear alkanes and isoprene most ineffective. Carbonyls led to significant increases in growth compared to the alkanes while alcohols, triple-bond compounds, aromatics, and epoxides were only slightly more effective than alkanes at producing SOA. When more than one double bond is present, or a double bond is present with another functional group as seen with 1, 2-epoxydec-9-ene, SOA yield is notably increased. Placement of the double bond is important as well with β-pinene having an SOA yield approximately 5 times that of α-pinene. In our photolytic flow reactor, first-generation oxidation products are presumed to be the primary species contributing to SOA thus the molecular structure of the precursor is determinant. We also conducted proton-transfer mass spectrometry measurements of α-pinene photooxidation and significant signals were observed at masses for multifunctional nitrates and possibly peroxy radicals. The mass spectrometer measurements were also used to estimate a HONO photolysis rate.
Social Isolation, Loneliness and Health: A Descriptive Study of the Experiences of Migrant Mothers With Young Children (0–5 Years Old) at La Maison Bleue
Authors: Lim Mona , Van Hulst Andraea , Pisanu Sarah , Merry Lisa 
Published: June 2022

BackgroundMigrant women with young children, including asylum seekers and refugees, have multiple vulnerability factors that put them at increased risk of social isolation and loneliness, which are associated with negative health outcomes. This study explored the experiences of social isolation and loneliness among migrant mothers with children aged 0–5 years as well as their perceptions on possible health impacts.MethodsA qualitative descriptive study was conducted at La Maison Bleue, a non-profit organization providing perinatal health and social services to vulnerable women in Montreal, Canada. Recruitment and data collection occurred concurrently during the COVID-19 pandemic, between November and December 2020. Eleven women participated in individual semi-structured interviews and provided socio-demographic information. Interview data were thematically analyzed.ResultsMigrant women in this study described social isolation as the loss of family support and of their familiar social/cultural networks, and loneliness as the feelings of aloneness that stemmed from being a mother in a new country with limited support. Multiple factors contributed to women's and children's social isolation and loneliness, including migration status, socioeconomic circumstances, language barriers, and being a single mother. Women expressed that the COVID-19 pandemic exacerbated pre-existing experiences of social isolation and loneliness. Mothers' experiences affected their emotional and mental health, while for children, it reduced their social opportunities outside the home, especially if not attending childcare. However, the extent to which mothers' experiences of social isolation and loneliness influenced the health and development of their children, was less clear.ConclusionMigrant mothers' experiences of social isolation and loneliness are intricately linked to their status as migrants and mothers. Going forward, it is critical to better document pandemic and post-pandemic consequences of social isolation and loneliness on young children of migrant families. Supportive interventions for migrant mothers and their young children should not only target social isolation but should also consider mothers' feelings of loneliness and foster social connectedness and belongingness. To address social isolation and loneliness, interventions at the individual, community and policy levels are needed.
Submarine Optical Fiber Sensing System for the Real-Time Monitoring of Depth, Vibration, and Temperature
Authors: Liu Zhengyong , Zhang Shengqi , Yang Chengkun , Chung Weng-Hong , Li Zhaohui 
Published: June 2022

Ocean observation becomes increasingly important as the ocean climate changes diversely and the marine disasters (such as tsunamis, typhoon, and earthquakes) occur frequently, which typically requires widespread and reliable monitoring techniques. In such a scenario, this paper presents a submarine optical fiber sensing system to realize real-time monitoring of the environmental parameters. The system consists of an undersea optical interrogation module together with multiple fiber Bragg grating (FBG)-based sensors, particularly for the measurement of depth, vibration, and temperature. The experimentally demonstrated sensitivities of the pressure, temperature, and vibration sensors are -1.993 nm/MPa, 0.08 nm/°C, and 0.139 nm/g (g = 9.8 m/s2), corresponding to the resolutions of 0.25 kPa, 0.006°C, and 0.004 g, respectively, based on the interrogation resolution of ~0.5 pm. To verify the feasibility and reliability of the proposed submarine sensing system, a prototype was developed and a proof test under the sea was conducted in an area close to Pearl River Estuary in China. The achieved results from the sea test show promising accuracy that is comparable to the commercially available electric-based sensors. Good characteristics of the surface water wave were observed by conducting the fast Fourier transform of the measured depth change, which shows a dominant frequency of ~0.25 Hz. The system provides the flexibility of replacing various optical fiber sensors easily and the capability of real-time monitoring in a remote way. The demonstrated submarine sensing system could find potential applications in real-time monitoring of the undersea ecosystem and the environmental evolution where multiparameter sensing is in demand.
Immunohistochemical Analysis of CYP11B2, CYP11B1 and β-catenin Helps Subtyping and Relates With Clinical Characteristics of Unilateral Primary Aldosteronism
Authors: Sun Luyan , Jiang Yiran , Xie Jing , Zhu Hongyuan , Wu Luming , Zhong Xu , Zhou Weiwei , Su Tingwei , Wang Weiqing 
Published: June 2022

Background: Primary aldosteronism is caused by aldosterone overproduction. While conventional hematoxylin-eosin staining can demonstrate morphological abnormality, it cannot provide any functional histopathological information. We aimed to identify the diagnostic, functional and prognostic value of CYP11B2, CYP11B1, and β-catenin immunostaining in unilateral hyperaldosteronism.Method: A total of 134 patients with unilateral hyperaldosteronism were recruited in our study. The expression of CYP11B2, CYP11B1, and β-catenin was evaluated semiquantitatively on 134 patients’ sections using immunohistochemistry technology and the relationship with clinical data was assessed.Results: Patients were classified into four subtypes based on CYP11B2 staining as below: (1)118 patients with unilateral single aldosterone-producing adenoma (APA), (2)11 with unilateral multiple APA, (3)four with aldosterone-producing cell cluster (APCC), and (4)one with an undefined source. Adjusted CYP11B2 H-score was correlated with serum aldosterone, aldosterone to renin ratio (ARR), and serum potassium. In the abnormal β-catenin staining group, hypertension duration, aldosterone, ARR, cortisol, tumor diameter, tumor area, and CYP11B2 H-score were significantly higher than those of the wild-type group. Serum potassium level was significantly lower in the abnormal β-catenin staining group. Age, gender, BMI, family history of hypertension, adjusted CYP11B2 and CYP11B1 H-scores differed significantly between complete clinical success and incomplete clinical success groups. Age, gender and family history of hypertension were independently associated with complete clinical success based on multivariate logistic regression analysis.Conclusion: CYP11B2 immunostaining could improve the differential diagnosis of unilateral hyperaldosteronism. Adjusted CYP11B2 H-score could be used as a histopathological marker to reflect the severity of unilateral APA. Dysregulation of Wnt/β-catenin signaling and impaired β-catenin degradation may provoke the proliferation and enhance the steroidogenic ability of APA tumor cells, indicating that the Wnt pathway might be a potential, actionable, therapeutic target in the treatment of hyperaldosteronism. Age, sex and family history of hypertension were independent predictors of clinical outcome after adrenalectomy for unilateral hyperaldosteronism.
Targeting Triple Negative Breast Cancer With Oncolytic Adenoviruses
Authors: Green-Tripp Gabriela , Nattress Callum , Halldén Gunnel 
Published: June 2022

Breast cancer (BC) is the most common cancer globally, accounting for 685,000 deaths in 2020. Triple-negative breast cancers (TNBC) lack oestrogen (ER) and progesterone (PR) hormone receptor expression and HER2 overexpression. TNBC represent 10–15% of all BC with high incidence in women under 50-years old that have BRCA mutations, and have a dismal prognosis. African American and Hispanic women are at higher risk partly due to the common occurrence of BRCA mutations. The standard treatment for TNBC includes surgery, radiotherapy, and chemotherapy although, resistance to all standard-of-care therapies eventually develops. It is crucial to identify and develop more efficacious therapeutics with different mechanisms of action to improve on survival in these women. Recent findings with oncolytic adenoviruses (OAds) may generate a new strategy to improve on the outcomes for women afflicted by TNBC and other types of BC. OAds are genetically engineered to selectively lyse, eliminate and recruit the host antitumour immune responses, leaving normal cells unharmed. The most common modifications are deletions in the early gene products including the E1B55 KDa protein, specific regions of the E1A protein, or insertion of tumour-specific promoters. Clinical trials using OAds for various adenocarcinomas have not yet been sufficiently evaluated in BC patients. Preclinical studies demonstrated efficacy in BC cell lines, including TNBC cells, with promising novel adenoviral mutants. Here we review the results reported for the most promising OAds in preclinical studies and clinical trials administered alone and in combination with current standard of care or with novel therapeutics. Combinations of OAds with small molecule drugs targeting the epidermal growth factor receptor (EGFR), androgen receptor (AR), and DNA damage repair by the novel PARP inhibitors are currently under investigation with reported enhanced efficacy. The combination of the PARP-inhibitor Olaparib with OAds showed an impressive anti-tumour effect. The most promising findings to date are with OAds in combination with antibodies towards the immune checkpoints or expression of cytokines from the viral backbone. Although safety and efficacy have been demonstrated in numerous clinical trials and preclinical studies with cancer-selective OAds, further developments are needed to eliminate metastatic lesions, increase immune activation and intratumoural viral spread. We discuss shortcomings of the OAds and potential solutions for improving on patient outcomes.
Effects of Tempeh Probiotics on Elderly With Cognitive Impairment
Authors: Handajani Yvonne Suzy , Turana Yuda , Yogiara Yogiara , Sugiyono Sagita Pratiwi , Lamadong Vincent , Widjaja Nelly Tina , Christianto Geovannie Audrey Moniqe , Suwanto Antonius 
Published: June 2022

IntroductionOral consumption of probiotics can alter Gut Microbiota by causing changes in the production of probiotic derivatives. Therefore, by utilizing Gut-Brain-Axis (GBA), probiotics could provide an opportunity for central nervous system (CNS) modulation, including cognitive function. Tempeh is a traditional Indonesian food rich in probiotics and beneficial for cognitive function. However, the type of probiotics that play a role in cognitive improvement and the number of probiotics needed for the benefits of increasing cognitive function was unknown.MethodThis experimental study involved a total of 93 subjects, divided into 3 groups: A, B and C/control (n: 33, 32, and 28), who were provided with probiotic supplementation isolated from tempeh for 12 weeks intervention. Inclusion criteria were age &gt; 60 years, and memory impairment with the third repetition value of Word List Memory Immediate Recall (WLMIR) &lt; 7. Subjects with diabetes were excluded. Cognitive function examinations were carried out before and after treatment. The tempeh-derived probiotics were prepared trough several processes. Genomic isolation, detection of GABA-encoding genes, and species identification using the 16S-rRNA gene encoding were performed.ResultsThe probiotics isolate used in the intervention was identified as Limosilactobacillus fermentum. We assigned this isolate as L. fermentum A2.8. The presence of the gene encoding GABA was found on this isolate. There was an increase in the cognitive domains of memory, learning process, and verbal fluency (p &lt; 0.05) in group A (probiotics at concentration of 108 CFU/mL). Memory function, visuospatial, and verbal fluency improved (p &lt; 0.05) in group B (probiotics at concentration of 107 CFU/mL). Only an increase in the memory domain was observed in the control group. Improvement of the learning process occurred only in group A (p = 0.006).ConclusionAdministration of probiotics derived from L. fermentum A2.8 increased the cognitive domains of memory, language and visuospatial function. However, probiotic supplementation at a concentration of 108 CFU/mL was better in improving the learning process. This study succeeded in detecting Lactic Acid Bacterial isolates L. fermentum A2.8 that enclosed gene encoding glutamate decarboxylase (gad) which is involved in the synthesis of -aminobutyric acid (GABA), a neurotransmitter vital for cognitive function.
Multiple-Network Alterations in Major Depressive Disorder With Gastrointestinal Symptoms at Rest Revealed by Global Functional Connectivity Analysis
Authors: Yan Meiqi , Fu Xiaoya , Ou Yangpan , Liu Feng , Li Huabing , Guo Wenbin 
Published: June 2022

ObjectiveGastrointestinal (GI) symptoms are prominent in major depressive disorder (MDD) and bring patients lots of complaints and troubles. We aimed to explore whether there were some distinctive brain image alterations in MDD with GI symptoms, which could be used to distinguish MDD with GI symptoms from those without GI symptoms and healthy controls (HCs).MethodsA total of 35 outpatients with GI symptoms, 17 outpatients without GI symptoms, and 28 HCs were recruited. All the participants were scanned by a resting-state functional magnetic resonance imaging. Imaging data were analyzed with the global functional connectivity (GFC) and support vector machine methods.ResultsMDD with GI symptoms showed decreased GFC in the left superior medial prefrontal cortex (MPFC) compared with MDD without GI symptoms. Compared with HCs, MDD with GI symptoms showed decreased GFC in the bilateral middle temporal pole (MTP) and left posterior cingulate cortex/precuneus (PCC/Pcu), and increased GFC in the right insula and bilateral thalamus. SVM analysis showed that an accuracy was 78.85% in differentiating MDD with GI symptoms from MDD without GI symptoms by using the GFC of the left superior MPFC. A combination of GFC of the left PCC/Pcu and bilateral MTP exhibited the highest accuracy (87.30%) in differentiating patients with MDD with GI symptoms from HCs.ConclusionMDD with GI symptoms showed abnormal GFC in multiple networks, including the default mode network and cortico-limbic mood-regulating circuit. Using abnormal GFC might work well to discriminate MDD with GI symptoms from MDD without GI symptoms and HCs.
The Association Between Fasting Blood Sugar and Index of Nutritional Quality in Adult Women
Authors: Alami Farkhondeh , Mohseni Golsa Khalatbari , Ahmadzadeh Mina , Vahid Farhad , Gholamalizadeh Maryam , Masoumvand Mohammad , Shekari Soheila , Alizadeh Atiyeh , Shafaei Hanieh , Doaei Saeid 
Published: June 2022

AimIt's unclear whether diet quality affects glycemic management. The index of nutritional quality (INQ) can examine diets both quantitatively and qualitatively (INQ). Hence, this study aimed to determine whether INQ and fasting blood sugar (FBS) are related among Iranian women.MethodsThis cross-sectional study was conducted on 360 adult Iranian women. Data were collected on the participants' general characteristics, medical history, anthropometric indices, physical activity, and dietary intake. For nutrient intake assessment, a valid food frequency questionnaire (FFQ) was used, and INQ was then calculated using the daily nutrient intake.ResultsAfter adjusting for age, FBS was significantly inverse associated with INQ for vitamins A (B = −0.193, p &lt; 0.01), magnesium (B = −0.137, p &lt; 0.01), phosphor (B = −0.175, p &lt; 0.01), zinc (B = −0.113, p &lt; 0.01), vitamin K (B = −0.197, p &lt; 0.01), manganese (B = −0.111, p &lt; 0.01) and selenium (B = −0.123, p &lt; 0.01). The association between FBS and INQ for Se and Mn was disappeared after further adjustment for gender, body mass index (BMI), menopausal status, and total energy intake.ConclusionThere was a significant inverse relationship between FBS and the INQ of vitamin A, manganese, phosphor, zinc, vitamin K, magnesium, and selenium. Prospective cohort studies should be conducted to establish a causal relationship between FBS and INQ.
Lactococcus lactis KF140 Reduces Dietary Absorption of Nε - (Carboxymethyl)lysine in Rats and Humans via β-Galactosidase Activity
Authors: Park Ho-Young , Lee Hye-Bin , Lee So-Young , Oh Mi-Jin , Ha Sang Keun , Do Eunju , Lee Hyun Hee L. , Hur Jinyoung , Lee Kwang-Won , Nam Mi-Hyun , Park Myoung Gyu , Kim Yoonsook 
Published: June 2022

Background and AimsExcessive intake of advanced glycation end products (AGEs), which are formed in foods cooked at high temperatures for long periods of time, has negative health effects, such as inflammatory responses and oxidative stress. Nε-(Carboxymethyl)lysine (CML) is one of the major dietary AGEs. Given their generally recognized as safe status and probiotic functionalities, lactic acid bacteria may be ideal supplements for blocking intestinal absorption of food toxicants. However, the protective effects of lactic acid bacteria against dietary AGEs have not been fully elucidated.Materials and MethodsWe investigated the effect of treatment with Lactococcus lactis KF140 (LL-KF140), which was isolated from kimchi, on the levels and toxicokinetics of CML. The CML reduction efficacies of the Lactococcus lactis KF140 (LL-KF140), which was isolated from kimchi, were conducted by in vitro test for reducing CML concentration of the casein-lactose reaction product (CLRP) and in vivo test for reducing serum CML level of LL-KF140 administered rats at 2.0 × 108 CFU/kg for14 days. In addition, 12 volunteers consuming LL-KF140 at 2.0 × 109 CFU/1.5 g for 26 days were determined blood CML concentration and compared with that before intake a Parmesan cheese.ResultsAdministration of LL-KF140 reduced serum CML levels and hepatic CML absorption in rats that were fed a CML-enriched product. In a human trial, the intake of LL-KF140 prevented increases in the serum levels of CML and alanine aminotransferase after consumption of a CML-rich cheese. LL-KF140 was determined to presence in feces through metagenome analysis. Furthermore, β-galactosidase, one of the L. lactis-produced enzymes, inhibited the absorption of CML and reduced the levels of this AGE, which suggests an indirect inhibitory effect of LL-KF140. This study is the first to demonstrate that an L. lactis strain and its related enzyme contribute to the reduction of dietary absorption of CML.