bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of the cardiac depressant effect of Caralluma tuberculate N.E.Br on isolated rabbit heart
Authors: Mahnashi Mater H , Ahmad Taseer , Alamgeer  , Mushtaq Muhammad Naveed , Malik Muhammad Nasir Hayat , Ahmad Maira , Javed Adil , Jalal Mohammed M , Altayar Malik A , Albloshi Abdullah 
Published: November 2022

Purpose: To investigate the histopathological and cardiac depressant effect of the aqueous methanol extract of Caralluma tuberculata N.E. Br (AMECT) (family: Asclepiadaceae)’ and to determine if there is a scientific basis for its cardiovascular diseases-related folkloric use.
Methods: The effect of AMECT in different concentrations ranging from 0.00001 to 1.0 mg/mL were evaluated in isolated perfused rabbit heart to assess their effect on the force of contraction and heart rate using Langendorff’s apparatus. Atropine and adrenaline were used to identify the underlying mechanism of response produced by AMECT. The extract was studied for its possible mechanism in the absence and presence of atropine and adrenaline. In addition, sub-chronic toxicity and histopathological study of heart tissues in rats were assessed by administering 500 mg/kg of extract.
Results: At all concentrations, AMECT produced significant (p < 0.001) negative ionotropic and negative chronotropic effects. The most significant effect was observed at 0.001 mg/mL and higher concentrations hence 0.001 mg/mL was selected for further studies. Pre-incubation with atropine did not significantly inhibit the effects of AMECT. However, AMECT significantly (p < 0.01) blocked the cardiac stimulant effect of adrenaline. In the histopathological studies, AMECT did not produce any significant cellular changes or signs of toxicity in the sub-chronic toxicity study.
Conclusion: The cardiac-depressant responses of AMECT may involve the β-adrenergic receptors in the myocardium of isolated rabbit heart thus confirming the rationale for its use in ethnomedicine for cardiac diseases.
Regulatory effect of resveratrol on the expressions of factors and surface markers in alveolar macrophages of Aspergillus fumigatus-infected COPD rat model, and the associated mechanism
Authors: Du Limei , Huo Xinglan , Liu Ying 
Published: November 2022

Purpose: To study the influence of resveratrol on chronic obstruction in Aspergillus fumigatus infection-induced chronic lung disease (COPD) in rats, and the process involved.
Methods: Seventy-five Sprague Dawley SD) rats were assigned to blank control, COPD model, Aspergillus fumigatus-infected COPD model, low (100 mg/kg) and high-dose (200 mg/kg) resveratrol groups, with 15 rats in each group. Enzyme-linked immunosorbent assay (ELISA) was used to assay IL-6, IL-8 and TNF-α in bronchoalveolar lavage fluid (BALF), while lung protein concentrations of AMPK and PGC-1α were assayed by immunoblotting.
Results: In low- and high-dose resveratrol groups, inflammatory factor levels were significantly lower than the corresponding levels in COPD model and Aspergillus fumigatus-infected COPD model (p < 0.05), while lung tissue proteins of AMPK, PGC-1α, and AQP5 of the rats given high-dose resveratrol were significantly raised, relative to corresponding levels in rats given low-dose resveratrol (p < 0.05).
Conclusion: Resveratrol modulates expression levels of secretory factors and surface markers in alveolar macrophages in COPD model rats infected with Aspergillus fumigatus. Resveratrol exerts this effect through the regulation of AMPK/PGC-1α signaling pathway.
Efficacy of the combination of Tenghuangjiangu tablets, alfacalcidol capsules and caltrate D3 tablets in osteoporotic vertebral compression fracture, and their effects on bone metabolic indices
Authors: Duan Xianbin , Liu Bi , Lu Xiaohu 
Published: November 2022

Purpose: To investigate the efficacy of the combination of Tenghuangjiangu tablets, Alfacalcidol capsules and Caltrate D3 tablets in osteoporotic vertebral compression fracture (OVCF) and their effects on bone metabolic indices.
Methods: Ninety-six patients with OVCF were randomly categorized into study group (SG) and control group (CG). Patients in the CG orally took Caltrate D3 tablets, while those in the SG were given Tenghuangjiangu tablets and Alfacalcidol capsules in addition to caltrate D3 tablets. The Bone mineral density (BMD) values and the treatment efficacy were compared. The levels of bone metabolism markers (PINP, β-CTX, BGP, NBAP), CT and PTH were determined using electrochemiluminescence immunoassay, while Ca2+ levels were assessed using liquid level detection. The incidence of adverse reactions (re-fracture, gastrointestinal reaction, hypotension and abnormal coagulation function) were compared.
Results: Treatment efficacy in the SG was 91.67 %, which was significantly higher than that in the CG (81.25 %; p < 0.05). Before treatment, the two groups showed no significant differences in BMD, PINP, β-CTX, BGP, NBAP, Ca2+, CT, and PTH levels (p > 0.05). After treatment, the SG exhibited significantly higher BMD, PINP, BGP, NBAP, Ca2+ and CT levels, and showed lower β-CTX and PTH levels than the CG (p < 0.05). The SG exhibited a significantly lower incidence rate of adverse reactions than that the CG (p < 0.05).
Conclusion: The combination of Tenghuangjiangu tablets, Alfacalcidol capsules, and Caltrate D3 tablets, improves bone metabolic indices, bone density and treatment efficacy while reducing the incidence rate of adverse reactions.
NUCKS1 promotes breast cancer cell proliferation and metastasis via PI3K/ AKT pathway
Authors: Li Song , Wang Daoliang 
Published: November 2022

Purpose: To investigate the role of nuclear casein kinase and cyclin-dependent kinase substrate 1 (NUCKS1) in breast cancer.
Methods: Breast cancer cells were maintained in RPMI-1640 medium containing 10 % fetal bovine serum in a incubator at 37 °C. Cell proliferation was determined by CCK8 and colony formation assays. Flow cytometry and Transwell assays were used to determine cell cycle and metastasis, respectively.
Results: Expression of NUCKS1 was significantly elevated in breast cancer (p < 0.01). Overexpression of NUCKS1 significantly increased cell viability (p < 0.01), and promoted proliferation of breast cancer cells. Knockdown of NUCKS1 inhibited cell proliferation, and induced cell cycle arrest at G1 phase. However, overexpression of NUCKS1 promoted cell cycle progression via down-regulation of p21 and up-regulation of cyclin D1 and CDK1. Cell migration and invasion were induced by overexpression of NUCKS1, and suppressed by silencing of NUCKS1. Overexpression of NUCKS1 enhanced p-AKT and p-PI3K expression, while knockdown of NUCKS1 reduced the expression of p-AKT and p-PI3K in breast cancer cells.
Conclusion: NUCKS1 promotes breast cancer cell proliferation and metastasis via activation of PI3K/AKT signaling. The silencing of NUCKS1 can be used as a strategy to develop therapies for the management of breast cancer.
Project for the implementation of techniques to reduce damage and consequences of mining dumps developed by the Higher Technological Institute of Fresnillo
Authors: Sánchez José de Jesús Reyes , Camacho Mario Alberto García , Vega Martha Alicia Guerrero 
Published: November 2022

The methodology presented consists of procedures for improvement and quality in the environment in a more specific way to implement the necessary indications to guide the proponent a safe work environment, focused on the mining dumps in preparation for their preparation in accordance with the Regulation of Mining Security. Based on a project which is considered for the implementation of techniques that promote the reduction of damage or consequences, generating a safer environment that cannot be harmful or unsafe for personnel and people nearby or who may have access to these areas. In mining, a large amount of waste is produced that brings with it affectations and damages generated especially to the environment, personnel and people who have access.
Barriers to Accessing Community Based Trauma-focused Cognitive Behavioral Therapy (TF-CBT) for Posttraumatic Stress Disorder (PTSD) Management in Post Conflict Acholi Sub-region
Authors: Amongi Elizabeth , Baguma Peter , Nansubuga Florence 
Published: November 2022

Purpose: The study aimed at assessing barriers in accessing Community-Based Trauma- Focused Cognitive Behavioral Therapy (TF-CBT) for Posttraumatic Stress Disorder (PTSD) management in post-conflict Acholi sub-region with interest in providing solutions to those barriers.
Methodology: The study adopted a survey approach which was qualitative. This was done through interviews. This was supplemented by the pragmatic paradigm that concerned assessing effectiveness of community-based TF-CBT. The research design used to assess barriers and facilitators of TF-CBT was cross sectional. The use of cross-sectional survey design involved the elements of comparative, exploratory and descriptive approaches. Sample selection of participants involved organizational staff comprising of, social workers, clinical psychologists, Village Health Team (VHTs). Beneficiaries who included 120 men and 299 women. The 419 beneficiaries were interrogated using a questionnaire, 36 participants for Focused Group Discussions (FGDs), four social workers and, one clinical psychologist and 25 in-depth interviews with beneficiaries.
Findings: Results indicated; limited mobilization, stigmatization, lack of enough human resource, alcoholism, lack of commitment and economic crisis amongst others as barriers to accessing TF-CBT for PTSD management. The study suggests that these can be handled through sensitization, radio talk shows, visiting clients in their homes and increasing number of staff. The study suggests community sensitization, recruiting more staff to handle TF-CBT, visitations by staff to clients, family support from spouses & caregivers and increased infrastructure as the recommended measure to handle this problem.
The HYPERMAQ dataset: bio-optical properties of moderately to extremely turbid waters
Authors: Lavigne Héloïse , Dogliotti Ana , Doxaran David , Shen Fang , Castagna Alexandre , Beck Matthew , Vanhellemont Quinten , Sun Xuerong , Gossn Juan Ignacio , Renosh Pannimpullath Remanan , Sabbe Koen , Vansteenwegen Dieter , Ruddick Kevin 
Published: November 2022

Abstract. Because of the large diversity of case 2 waters ranging
from extremely absorbing to extremely scattering waters and the complexity
of light transfer due to external terrestrial inputs, retrieving main
biogeochemical parameters such as chlorophyll-a or suspended particulate
matter concentration in these waters is still challenging. By providing
optical and biogeochemical parameters for 180 sampling stations with
turbidity and chlorophyll-a concentration ranging from 1 to 700 FNU and from
0.9 to 180 mg m−3 respectively, the HYPERMAQ dataset will contribute to
a better description of marine optics in optically complex water bodies and
can help the scientific community to develop algorithms. The HYPERMAQ
dataset provides biogeochemical parameters (i.e. turbidity, pigment and chlorophyll-a concentration, suspended particulate matter), apparent optical
properties (i.e. water reflectance from above water measurements) and inherent optical properties (i.e. absorption and attenuation coefficients)
from six different study areas. These study areas include large estuaries
(i.e. the Rio de la Plata in Argentina, the Yangtze estuary in China, and the Gironde estuary in France), inland (i.e. the Spuikom in Belgium and
Chascomùs lake in Argentina), and coastal waters (Belgium). The dataset is
available from Lavigne et al. (2022) at https://doi.org/10.1594/PANGAEA.944313.
Cosmogenic 3He paleothermometry on post-LGM glacial bedrock within the central European Alps
Authors: Gribenski Natacha , Tremblay Marissa M. , Valla Pierre G. , Balco Greg , Guralnik Benny , Shuster David L. 
Published: November 2022

Abstract. Diffusion properties of cosmogenic 3He in quartz at Earth surface temperatures offer the potential to directly reconstruct the evolution of past
in situ temperatures from formerly glaciated areas, which is important information for improving our understanding of glacier–climate
interactions. In this study, we apply cosmogenic 3He paleothermometry to rock surfaces gradually exposed from the Last Glacial Maximum
(LGM) to the Holocene period along two deglaciation profiles in the European Alps (Mont Blanc and Aar massifs). Laboratory experiments conducted on
one representative sample per site indicate significant differences in 3He diffusion kinetics between the two sites, with quasi-linear
Arrhenius behavior observed in quartz from the Mont Blanc site and complex Arrhenius behavior observed in quartz from the Aar site, which we
interpret to indicate the presence of multiple diffusion domains (MDD). Assuming the same diffusion kinetics apply to all quartz samples along each
profile, forward model simulations indicate that the cosmogenic 3He abundance in all the investigated samples should be at equilibrium with
present-day temperature conditions. However, measured cosmogenic 3He concentrations in samples exposed since before the Holocene indicate an
apparent 3He thermal signal significantly colder than today. This observed 3He thermal signal cannot be explained with a realistic
post-LGM mean annual temperature evolution in the European Alps at the study sites. One hypothesis is that the diffusion kinetics and MDD model
applied may not provide sufficiently accurate, quantitative paleo-temperature estimates in these samples; thus, while a pre-Holocene 3He
thermal signal is indeed preserved in the quartz, the helium diffusivity would be lower at Alpine surface temperatures than our diffusion models
predict. Alternatively, if the modeled helium diffusion kinetics is accurate, the observed 3He abundances may reflect a complex
geomorphic and/or paleoclimatic evolution, with much more recent ground temperature changes associated with the degradation of alpine permafrost.
Health Information Technology During during the COVID-19 Epidemic
Authors: Dastani Meisam , Atarodi Alireza 
Published: November 2022

Background: Due to the prevalence of the COVID-19 epidemic in all countries of the world, the need to apply health information technology is of great importance. Hence, the study has identified the role of health information technology during the period of COVID-19 epidemic.
Methods: The present research is a review study by employing text-mining techniques. Therefore, 941 published documents related to health information technology's role during COVID-19 epidemic were extracted by keyword searching in the Web of Science database. In order to analyze the data and implement the text mining and topic modeling algorithms, Python programming language was applied.
Results: The results indicated that the highest number of publications related to the role of health information technology in the period of COVID-19 epidemic was respectively on the following topics: “Models and smart systems,” “Telemedicine,” “Health care,” “Health information technology,” “Evidence-based medicine,” “Big data and statistic analysis.”
Conclusion: Health information technology has been extensively used during COVID-19 epidemic. Therefore, different communities could apply these technologies, considering the conditions and facilities to manage COVID-19 epidemic better.
PENETAPAN KADAR VITAMIN C PADA BUAH MANGGA ARUMANIS (Mangifera indica L) DAN BUAH MANGGA MACANG (Mangifera foetida Lour) DENGAN METODE SPEKTROFOTOMETRI UV-VIS
Authors: Mulyani Elly 
Published: November 2022

ABSTRAKÂ Vitamin C adalah salah satu zat gizi yang berperan sebagai antioksidan dan efektif mengatasi radikal bebas yang dapat merusak sel atau jaringan. Buah-buahan merupakan sumber vitamin C, diantarnya yaitu buah mangga. Penelitian ini bertujuan untuk menetapkan kadar vitamin C dalam buah mangga menggunkan metode spektrofotometri UV-Vis, serta membandikan hasil dari kedua mangga tersebut. Sampel yang diidentifikasi yaitu buah mangga yang sudah matang. Hasil analisis vitamin C mangga arumanis menghasilkan kadar 0,0057%, sedangkan kandungan vitamin C pada buah mangga macang mengasilkan kadar 0,0094%. Dari hasil tersebut menunjukan kadar vitamin C yang didapat mangga macang lebh besar daripada mangga arumanis.
GAMBARAN PENGGUNAAN OBAT GASTROENTERITIS PADA PASIEN PEDIATRI RAWAT INAP DI RUMAH SAKIT HARAPAN DAN DOA KOTA BENGKULU
Authors: Rikomah Setya Enti 
Published: November 2022

Gastroenteritis merupakan Â masalah yang paling sering terjadi di negara berkembang termasuk Indonesia, angkakejadian Gastroenteritis disebagianwilayah Indonesia hingga saat ini masih tinggi. Hal ini terjadi disebabkan rendahnya ketersediaan air bersih, sanitasi dan perilaku hidup yang tidak sehat.Penelitian ini dilakukan untuk mengetahui gambaran penggunaan obat Gastroenteritis pada pasien pediatri rawat inap di Rumah Sakit Harapan dan Doa Kota Bengkulu pada bulan Januari sampai dengan Maret tahun 2020. Penelitian ini merupakan penelitian retrospektif, dengan perhitungan sampel dilakukan dengan menggunakan rumus cross secsional dengan jumlah responden dalam penelitian 28 pasien. Hasil penelitian ini menunjukan penggunaan obat Gastoenteritis yang paling banyak digunakan adalah L-Bio sebesar 57% dilanjutkan dengan Oralit sebesar 31% dan Zinc sebesar 11%, dan yang paling sedikit digunakan adalah Domperidone 1%.
GAMBARAN TINGKAT PENGETAHUAN TENTANG NYERI HAID (DYSMENORRHEA) DAN CARA MENANGANINYA PADA SISWI SMA NEGERI 01 LEBONG
Authors: Lestari Gina 
Published: November 2022

Istilah dysmenorrhe berasal dari kata dalam bahasa yunani kuno (Greek) Â kata tersebut barasal dari dys yang berarti sulit, nyeri, abnormal, meno yang berarti bulan, dan rrhea yang berrati aliran atau arus.Secara singkat disminorea dapat didefenisikan sebagai aliran menstruasi yang sulit atau menstruasi yang mengalami nyeri. Dalam penelitian ini bertujuan untuk mendeskripsikan tingkat pengetahuan siswi tentang nyeri haid (dysmenorrhea) dan untuk mengetahui cara siswi menangani nyeri haid (dysmenorrhea).Metode analisa data yang digunakan pada penelitan ini merupakan metode deskriptif dan kualitatif. Penelitian ini dilakukan di SMA Negeri 01 Kabupaten Lebong pada pada tanggal 10 Juni sampai 10 Juli 2020 dengan jumlah sampel 91 siswi. Pengumpulan data menggunakan data primer yang diperoleh langsung dari responden melalui kuesioner dan data sekunder meliputi jumlah siswi yang didapat dari SMAN 01 Lebong tahun ajaran 2020.Hasil penelitian diperoleh sebanyak 51,64% siswi dengan tingkat pengetahuan cukup tentang nyeri haid (dysmenorrhea), 25,27% berpengetahuan baik tentang nyeri haid (dysmenorrhea) dan 22,58% berpengetahuan kurang tentang nyeri haid (dysmenorrhea). Sedangkan untuk cara menanganinya sebanyak 41,75% siswi menangani nyeri haid (dysmenorrhea) dengan cukup, 21,97% siswi menangani nyeri haid (dysmenorrhea) dengan baik, dan 36,26% siswi menangani nyeri haid (dysmenorrhea) dengan kurang.
Formulasi Blush on Compact Powder dari Ekstrak Biji Kesumba Keling (Bixa orellana L.)
Authors: Dharmayanti Luky Dharmayanti 
Published: November 2022

Blush on merupakan salah satu jenis kosmetik dekoratif yang digunakan didaerah pipi dengan tujuan untuk menambah nilai estetika pada wajah. Saat ini banyak sediaan blush on di pasaran yang mengandung bahan kimia berbahaya, oleh sebab itu dibuatlah sediaan blush on dari ekstrak biji kesumba keling (Bixa orellana L.) yang mengandung pigmen biksin dan norbixin. Ekstrak diperoleh dengan cara maserasi dengan pelarut etanol 96% maserat dipekatkan dengan rotary evaporator.Â Formula blush on compact powder yang dibuat yaitu menggunakan zat warna dari biji kesumba keling dengan konsentrasi 5%, 11%Â dan 15%. Uji evaluasi blush on meliputi uji organoleptis, uji homogenitas, uji pH, uji iritasi, uji keretakan dan uji hedonik. Hasil penelitian menunjukan bahwa ekstrak biji kesumba keling dapat diformulasikan menjadi sediaan blush on compact powder pada uji organoleptis diperoleh warna ekstrak sebagai zat aktif, uji pH memenuhi persyaratan diperoleh rata-rata pH 7,2, uji homogenitas menunjukan bahwa tidak adanya butiran kasar, uji iritasi pada 10 panelis tidak menunjukan adanya iritasi pada kulit, uji keretakan memenuhi persyaratan ketika di jatuhkan tidak ada sediaan yang retak. Uji hedonik formula 3 yang paling bagus.
POTENSI EKSTRAK DAUN SALAM KOJA (Murraya koenigii L. Spreng ) TERHADAP MORTALITAS Pediculus humanus capitis
Authors: Hayati Inayah 
Published: November 2022

KutuÂ kepala Â (Pediculus humanus capitis) Â merupakan parasit obligat yang siklus hidupnya mulai dari pradewasa sampai dewasa hidup bergantung pada inangnya. Infestasi yang lebih berat dari ektoparasit ini dapat berdampak pada timbulnya rasa gatal yang berlebihan, dapat menyebabkan luka lecet pada kulit kepala. Tujuan penelitian ini untuk mengetahui efektifitas ekstrak daun salam koja (Murraya koeniggi L.Spreng.) terhadap mortalitas Pediculus humanus capitis. Penelitian ini menggunakan metode penelitian eksperimental Â laboratorik Â dengan Â menggunakanÂ teknik Â Purposive Â Sampling. Sampel yang dibutuhkan dalam penelitian ini adalah ekstrak daun salam koja (Murraya koeniggi) dengan konsentrasi pengenceran 25%, 50%, 75% dan 100%. Berdasarkan hasil penelitian Â Ekstrak Daun Salam KojaÂ (Murraya koeniggi L.Spreng) dapat menyebabkan mortalitas kutu kepala (PediculusÂ humanusÂ capitis)Â pada konsentrasi 25 %, 50%, 75% dan 100 %. Pada konsentrasi 100% mortalitas kutu kepalaÂ yang lebih cepat dibandingkan dengan konsentrasi lainnya dengan waktu rata-rata kematian 02 menit 32 detik.
AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL KULIT BUAH TAMPOI (Baccaurea macrocarpa)
Authors: Rahman Ika Ristia 
Published: November 2022

Buah tampoi merupakan buah hutan tropis yang pemanfaatannya hanya pada daging buah yang dikonsumsi. Pemanfaatan kulit buah Tampoi belum dilakukan secara maksimal. Ekstrak kulit buah tampoi mengandung senyawa metabolit sekunder seperti alkaloid, flavonoid, fenol, tannin dan saponin. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri pada bakteri E. coli, S. aureus dan P. acne dari ekstrak etanol kulit buah tampoi dengan metode disk diffusion.Â Hasil pengujian aktivitas antibakteri ekstrak etanol kulit buah tampoi, pengujian pada bakteri E. coli, S. aureus dan P. acne, dilihat dari diameter daya hambat yang diberikan kulit buah tampoi memiliki potensi sebagai antibakteri. Semakin besar konsentrasi ekstrak kulit buah tampoi yang digunakan, semakin besar diameter daya hambat.
Uji Aktivitas Antioksidan Variasi Perlakuan Bunga Telang (Clitoria Ternatea L ) Dengan Metode DPPH.
Authors: Jannah Syauqul 
Published: November 2022

Bunga telang ( Clitoria Ternatea L ) mengandung senyawa antosianin golongan flavonoid. Antosianin mampu memperlambat penuaan, menghambat penyakit netrologis, inflamasi, diabetes, dan infeksi bakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari bunga telang (Clitoria Ternatea L).Â Â Â Â Â Â Â Â Â Â Â Penelitian ini dilakukan dengan membuat seri bunga telang segar dan kering (Clitoria Ternatea L) yaitu 1.250 ppm, 2.500 ppm, 3.750 ppm, 5000 ppm, dan 6.250 ppm. Sebagai blanko yang digunakan DPPH 0,1 mM. Pengujian dilakukan dengan metode DPPH. Data yang diperoleh kemudian dihitung aktivitas antioksidannya dan dihitung nilai IC50.Â Â Â Â Â Â Â Â Â Â Â Hasil peneltian menunjukan bahwa variasi perlakuan bunga telang (Clitoria Ternatea L) memiliki kemampuan antioksidan. Bunga telang segar tergolong lemah, bunga telang kering tergolong sedang dan Vitamin C tergolong sangat kuat. Nilai aktvitas antioksidan dan IC50 dari bunga telang segar sebesar 2.735 ppm, bunga telang kering sebesar 126,80, dan Vitamin C sebesar 1,85 ppm