bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonlinear analysis of the efficiency and saturation length of free electron laser with realistic helical wiggler and ion-channel guiding
Authors: kheiri golshad 
Published: April 2022

Abstract
A nonlinear study of the efficiency, power, and the saturation length of a free-electron laser with realistic helical wiggler and ion-channel guiding using numerical simulation is presented. A set of coupled nonlinear differential equations is derived using the Lorentz force equation for the ensemble of electrons and Maxwell’s equations for radiation waves. To calculate the efficiency, power, and the saturation length of the amplifier, these equations are solved simultaneously using a code developed in this study. By choosing different values of the plasma frequency of ion-channel guiding, the dominant mode for the group I and group II orbits is found. The effect of ion-channel guiding on efficiency and saturation length was studied, and the results show that ion-channel guiding increases efficiency and reduces saturation length. Moreover, the efficiency increases, and the saturation length decrease when the annular electron beam is substituted for a solid electron beam. Finally, the results show that the efficiency of a realistic wiggler free-electron laser is higher than that of an idealized one, while the saturation length is lower.
Immunofluorescence and Biochemical Investigation of the Protective Effects of Naringin and Diosmin on the Freezability of Merino Ram Semen
Authors: Ömür Ali Doğan , Kaynar Özgür , İleritürk Mustafa , Özkaraca Mustafa , Öztürk Ali Erdem , Bodu Mustafa , Şahin İpek Nur , akarsu serkan 
Published: April 2022

Abstract
In this study, the effects of diosmin and naringin on freezability of ram semen were investigated. For this purpose, 6 Merino rams were used during the breeding season. The ejaculates were pooled after being collected from the rams. Pooled ejaculates were divided into 6 groups as control (C; no additive) Naringin (1, 2, and 4 mM) and Diosmin (2 and 4 mM) groups, and then reconstituted with TRIS-based diluent. Pooled semen was equilibrated, placed in 0,25 mL straws with 10 × 107 sperm cells in each straw and frozen in liquid nitrogen vapor. After waiting for 24 hours, the straws were thawed at 37 oC for 25 s and analyzes were made. There was no statistical difference in total motility between the groups. D2 and D4 preserved the integrity of the plasma membrane better than the other groups. D4 showed better effect than other groups in terms of acrosome integrity, there was no difference between the groups in terms of mitochondrial activity. In the analysis of the sperm membrane lipid profile, it was observed that the diosmin added group had the highest lipid-phospholipid ratio. In the sperm membrane protein profile analysis, it was observed that both additives had protective effects at different levels. The highest total protein amount was seen in D4 and N4 groups. 8-OhDG positivity was more common in the control group than in the diosmin and naringin groups. Cu-Zn SOD positivity was less in the control group but more intense in all other groups. The positives were especially in the acrosome parts of the sperm cells.
The Impact of COVID-19 on Autologous Stem Cell Transplantation in Multiple Myeloma A single-centre service evaluation
Authors: Camilleri Marquita , Bekris Georgios , Sidhu Govundeep , Buck Caroline , Elsden Esme , McCourt Orla , Horder Jackie , Newrick Fiona , Lecat Catherine , Sive Jonathan , Papanikolaou Xenofon , Popat Rakesh , Lee Lydia , Xu Ke , Kyriakou Charalampia , Rabin Neil , Yong Kwee , Fisher Abi 
Published: April 2022

Abstract
Autologous stem cell transplantation (ASCT) is standard of care in biologically fit, newly diagnosed multiple myeloma (MM) patients, offering better therapeutic outcomes and improved quality of life (QoL). However, with the UK’s 1st national lockdown on 23/03/2020, several guidelines recommended deferring ASCT due to risks of infection, with resource limitations forcing some units to suspend ASCT entirely. Such changes to patients’ treatment plans inevitably altered their lived experience during these uncertain times with expected impact on QoL. We conducted a qualitative study using semi-structured interviews to gain insight into MM patients’ understanding of their disease, initial therapy and ASCT, and their response to therapy changes. A clinical snapshot of how COVID-19 affected the MM ASCT service in a single UK institution is also provided, including changes to chemotherapy treatment plans, timing, and prioritisation of ASCT. Framework analysis identified 6 overarching themes: 1) beliefs about ASCT, 2) perceptions of information provided about MM and ASCT, 3) high levels of fear and anxiety due to COVID-19, 4) feelings about ASCT disruption or delay due to COVID-19, 5) perceptions of care and 6) importance of social support. Example subthemes were beliefs that ASCT would provide a long-remission/best chance of normality including freedom from chemotherapy and associated side-effects, disappointment, and devastation at COVID-related treatment delays (despite high anxiety about infection) and exceptionally high levels of trust in the transplant team. Such insights will help us adjust our service and counselling approaches to be more in tune with patients’ priorities and expectations.
A case of ANCA-associated vasculitis in a 16-year-old female following SARS-COV-2 infection and a systematic review of the literature
Authors: Bryant Maria C , Spencer L. Terry , Yalcindag Ali 
Published: April 2022

Abstract
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare form of vasculitis in children. SARS-CoV-2, the virus that causes COVID-19 infection, seems to trigger autoimmunity and new-onset autoimmune disease in pediatric and adult patients. We present a case of new-onset AAV following COVID-19 infection in an adolescent patient, and we review the literature of AAV following COVID-19 infection. Case presentation: An adolescent female with a history of asthma was diagnosed with mild COVID-19 infection and subsequently developed persistent cough, wheezing, hearing loss, arthralgias, and rash. Her imaging and laboratory workup showed pulmonary nodules and cavitary lesions, elevated inflammatory markers, negative infectious testing, and positive ANCA. She was treated with corticosteroids, rituximab, and mycophenolate. At six-month follow-up, she had improvement in her symptoms, pulmonary function tests, imaging findings, and laboratory markers. Conclusions: We report the second case of new-onset anti-PR3, C-ANCA vasculitis and the fourth case of pediatric-onset AAV following COVID-19 infection. A systematic review of the literature found 6 cases of new-onset AAV in adults after COVID-19 infection. Pediatric and adult patients who develop AAV post COVID-19 infection have few, if any, comorbidities, and show marked radiographic and symptomatic improvement after treatment. There is increasing evidence for COVID-19-induced autoimmunity in children and our case highlights the importance of considering AAV in a child following a recent COVID-19 infection because timely treatment may improve clinical outcomes.
Characterizing the effects of stormwater runoff on dissolved organic matter in an urban river (Jiujiang, Jiangxi Province, China) using spectral analysis
Authors: Yuan Keting , Wan Qiong , Chai Beibei , Lei Xiaohui , Kang Aiqing , Chen Jianghai , Chen Xiang , Shi Hongwei , He Lixin , Li Ming 
Published: April 2022

Abstract
The effect of stormwater runoff on dissolved organic matter (DOM) in rivers is one of the central topics in water environment research. Jiujiang is one of the first cities established in the Green Development Demonstration Zone of the Yangtze River Economic Belt (Jiangxi Province, China). Three-dimensional excitation–emission matrix fluorescence with parallel factor analysis (3DEEM-PARAFAC) and ultraviolet–visible (UV-Vis) spectroscopy were used to explore the effects of runoff on organic matter in Shili River (Jiujiang, Jiangxi Province, China). The results show that the runoff led to an increase of some critical pollutants and DOM concentrations, especially in the middle reaches of the river. The concentration and relative molecular weight of DOM in water increased as a result of runoff. Three humic-like (C1–C3) and two protein-like (C4 and C5) components of DOM were identified using the PARAFAC model. The sources of the three humic-like components were consistent, unlike those of the protein-like component C4. The runoff contained lower amounts of humic compounds which caused the relative content and proportion of humic substances little change and protein-like species increasing. The DOM mainly derived from autochthonous sources, and runoff had limited effect on its characteristics. The PARAFAC components could adequately represent different indicators and sources of DOM in urban rivers, providing an important reference for urban river management.
Anxiety in Autism Spectrum Disorder: clinical characteristics and the role of the family.
Authors: Guerrera Silvia , Pontillo Maria , Tata Maria Cristina , Vincenzo Cristina Di , bellantoni domenica , Napoli Eleonora , Valeri Giovanni , Vicari Stefano 
Published: April 2022

Abstract
Background: Anxiety Disorder (AD) is among the most common psychiatric comorbidities in children and adolescents with Autism Spectrum Disorder (ASD). However, findings regarding the characterization of anxiety symptoms and the use of validated measures for children with ASD and AD are inconsistent. Parental psychological distress (PPD) has been linked to anxiety symptoms in children with ASD. This study aims to identify and to explore clinical characteristics of anxiety symptoms in ASD. Furthermore we shed light on the possible presence of PPD involving families of children and adolescents with ASD and AD. Methods: The final sample consisted of 75 children and adolescents (Mean age: 11,8 ± 2,3 years; Range age: 8-16 years) and their parents. Participants were divided into three groups based on the diagnosis: children and adolescents with a diagnosis of Autism Spectrum Disorder and Anxiety Disorders in comorbidity, children and adolescents with a diagnosis of Anxiety Disorders but without a diagnosis of Autism Spectrum Disorder, children and adolescents with a diagnosis of Autism Spectrum Disorder but without a diagnosis of Anxiety Disorders.Results: Results show the presence of clinical phenotype ASD+AD with specific features than AD group (p = 0,00003). A major functional impairment is reported for ASD+AD group compared the other groups. Finally, parents of the ASD+AD group reveal higher levels of PPD than AD (p = 0,005). Conclusions: Understanding clinical characteristics of anxiety disorder and the role of PPD could define individualized treatments and a better prognosis in children and adolescents with ASD and AD
Quantitative study of medical doctors’ professional identity formation: General picture and importance of experiences in the ‘community of practice’
Authors: Tagawa Masami 
Published: April 2022

Abstract
BackgroundProfessional identity formation (PIF), the development of professional values, actions, and aspirations, is the process of personal and professional development. PIF of medical doctors is now recognized as the goal of medical education and the construction of professional identity (PI) has been discussed. To evaluate medical trainees’ and doctors’ PI, a scale to evaluate overall professional development (developing scale, DS) and Kegan’s stage attributes specific scales (SASs) have been developed. Using these scales, this research aimed to reveal PI from young medical trainees to experienced doctors, and elucidate factors related to PIF.MethodsMedical students, residents, and medical doctors who have diverse clinical experiences working in Kagoshima University Hospital were asked to respond to a self-administered anonymous questionnaire and to list up to three important events and experiences that affected their present attitude as a medical doctor, in addition to answer items on demographic characteristics.Scores on the PIF scales were compared among respondent groups, and factors related to scale scores were analyzed. Listed experiences were categorized by topic themes and timing and the number of respondents listed in each category were analyzed by their scale scores and by estimated PI stage.ResultsMean DS scores of medical students, residents, and medical doctors were 68.8, 72.2, and 73.8, respectively, and scores were higher in medical doctors with longer clinical experience. Age for students’ DS and SAS-2 scores, and length of clinical experience for medical doctors’ DS, SAS-3, and SAS-h scores were significant factors.Respondents who were estimated to be at a higher stage of PI listed more professional related experiences. Respondents with high scores on each PIF scale reported more professional related experiences than lower scoring groups.ConclusionsQuantitative research indicated that PIF of medical doctors continued for decades after graduation, and the length of clinical experience might be an important factor for PIF. Professional and personal experiences were recognized as important by medical trainees and doctors, especially people at higher stages of PI. The experiences of medical trainees and doctors at different training phases showed a tendency to link to specific attributes.
Effect of different preparation conditions on the properties of nano-hydroxyapatite/bamboo fiber composite membrane
Authors: Liuyun Jiang , Jiang Zhihong , Ma Bingli , Ma Yingjun , Wen Yue , Zhang Na , Zhang Yan , Su Shengpei , Tang Xionggui , Hu Xiang 
Published: April 2022

Abstract
A novel nano-hydroxyapatite/bamboo fiber (n-HA/BF) composite membrane was obtained by a simple casting technique. The membrane forming mechanism and the effects of different forming membrane methods, drying methods and n-HA amounts on the properties of n-HA/BF composite membrane were investigated by Fourier Transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), contact angle, electromechanical universal tester, in vitro soaking in simulated body fluid (SBF) and in vitro cell culture experiment. The results demonstrated that the dispersity of n-HA nanoparticles in BF matix was not affected by the prepartion condition, however, the morphologies of membrane was determined by the different preparation conditions owing to different hydrogen bond shrinkage. Moreover, the hydrophilicity of the composite membrane was improved under the condition of the membrane formation in oven, freeze drying and high addition content of n-HA, and the mechanical properties of composite membrane depended on n-HA content. In vitro soaking behavior indicated that the degradability and bone-like apatite deposition could be controlled by different preparation conditions. And the cell proliferation experiment showed that the n-HA/BF composite membranes obtained under different preparation conditions were all non-toxic. The above results indicated that the casting technique could be used to prepare n-HA/BF composite membrane, and the properties of the composite membrane could be controlled by adopting different preparation conditions, which would have a great promising as guide bone tissue regeneration (GBR) membrane, and the study would provide a new application for BF in biomedical field.
Effects of the appearance care on psychosocial outcomes for breast cancer: a systematic review and meta-analysis
Authors: Zhu Mengyao , Sun Shihao , Zhang Yiheng , Chen Lili , He Haiyan , Chen Juanjuan , zhang Ni , Zhang Meifen 
Published: April 2022

Abstract
Purpose To synthesize the evidence for the immediate and short-term effects of appearance care on psychosocial outcomes in breast cancer patients in order to inform the design of future research and clinical practice.Methods A search of four databases (PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science). The JBI Critical Appraisal Checklists were used by two reviewers to assess methodology quality. Subgroup analysis was conducted for the different time points measured after intervention.Results Seven studies were eligible for the meta-analysis, including two RCTs and five quasi-experimental studies, from 1994 to 2022. The type of intervention was mainly grouped-education, led by beauty specialists, and the dose and frequency varied. The quality of included studies was moderate to high. The results showed that appearance care had positive immediate effect on self-esteem (SMD = 0.63, 95% CI 0.37 to 0.89), anxiety (SMD = -0.46, 95% CI -0.60 to -0.31), and depression (SMD = -0.41, 95% CI -0.62 to -0.19), with short-term effects on anxiety (SMD = -0.42, 95% CI -0.54 to -0.34), depression (SMD = -0.41, 95% CI -0.55 to -0.26) and sexual function (SMD = 0.50, 95% CI 0.18 to 0.81).The effect of appearance care on body image and quality of life was uncertain.Conclusion Appearance care could be a promising intervention to improve self-esteem, anxiety, depression, and sexual function among patients with breast cancer. More high-quality RCTs are needed to validate these findings. Online appearance care programs and exploration of long-term effects should also be considered.
Construction of antibacterial nano-silver embedded bioactive hydrogel to repair infectious skin defects
Authors: Dong Qi , Zu Dan , Kong Lingqiang , Chen Sunfang , Yao Jun , Lin Jiawei , Lu Lei , Wu Bing , Fang Bin 
Published: April 2022

Abstract
Background: Hydrogels loaded with antimicrobial agents have been widely developed for the treatment of infected wound defects. However, hydrogels derived from a porcine dermal extracellular matrix (PADM), containing silver nanoparticles (AgNPs), have not yet been studied. Therefore, we investigated the therapeutic effect of a AgNP-impregnated PADM (AgNPs-PADM) hydrogel in the treatment of infected wound defects. Methods: A AgNPs-PADM hydrogel was synthesized by embedding AgNPs into a PADM hydrogel. We examined the porosity, moisture retention, degradation, antibacterial properties, cytotoxicity, antioxidant properties, and ability of PADM and AgNPs-PADM hydrogels to treat infected wounds in animals. Results: The PADM and AgNPs-PADM hydrogels were pH-sensitive, which made them flow dynamically under acidic conditions and become solid under neutral conditions. They also demonstrated porous network structures, satisfactory moisture retention, and slow degradation rates. Meanwhile, the AgNPs-PADM hydrogel showed a slow and sustained release of AgNPs for at least seven days without changing the size of the particles, so that they could exhibit adequate antibacterial ability, negligible toxicity, and antioxidant properties in vitro. Moreover, the AgNPs-PADM hydrogel successfully promoted the angiogenesis and wound healing of infected skin defects in vivo. Conclusions: A AgNPs-PADM hydrogel is a promising bioderived antibacterial material for clinical infected wound dressings.
The accuracy of first metatarsophalangeal joint palpation guided injections. An arthrography cadaveric study
Authors: Reilly Ian Neil , Naemi Roozbeh , Chockalingam Nachiappan 
Published: April 2022

Abstract
BackgroundInjectable glucocorticoids are widely used in the management of foot pathology, in particular for the treatment of osteoarthritis of the great toe - hallux limitus/rigidus. Injections can be performed using anatomical (blind) guided methods or performed with needle placement aided by the use diagnostic imaging with ultrasound or fluoroscopy, with or without the use of contrast media.AimPalpation and image guided injection techniques have been studied in other joints of the body but less so for the first metatarsophalangeal joint of the foot, where palpation guidance is commonly performed. The aim of this study was to investigate the injection accuracy of palpation guided injections of the first metatarsophalangeal joint in six cadaveric feet using radio-opaque contrast media.MethodsThe injection equipment consisted of a 2.5ml Luer lock syringe and a 23-gauge needle used to inject iohexol (Omnipaque 300) into the first metatarsophalangeal joint in six cadaveric specimens. The needle was placed into the joint space by a single practitioner using palpation guidance. The contrast media was injected under live (cine) view without further movement or ingress of the needle. The injectate was considered accurate if the media coated the inside of the synovial membrane and/or outlined the joint shape.FindingsFailure of technique was seen in one of six feet, and extravasation of contrast media beyond the joint margins noted in three out of six feet.ConclusionsFurther study on a large sample of live subjects using a variance of technique is required to expand the confidence of these findings but the high failure rate calls into question the confidence of palpation guided techniques for injection of the first metatarsophalangeal joint.
Patient dissatisfaction associated with physician-patient linguistic discordance in California clinics: An analytical cross-sectional study
Authors: Fernández-Ortega Miguel Ángel , Juárez-Flores Arturo , Olaiz-Fernández Gustavo Adolfo , Muñiz-Salinas Daniel Alejandro ,   AB1045 Law Analysis Group, Rodríguez-Mendoza Omar 
Published: April 2022

Abstract

Background: Patient satisfaction is considered as a product of two psychological processes, a cognitive one, including expectations and perceptions, and an emotional one resulting from the congruence between expectation and subjective perception of the user. The objective was to identify the factors associated with the level of perceived satisfaction in patients treated in 36 nonprofit health clinics that offer comprehensive health care services in four counties in the state of California, United States.Methods: Cross-sectional analytical study in 14 clinics in four California counties. It consisted of the application of a 30-question questionnaire to determine the degree of patient satisfaction with the clinic. The factorial composition of the quality of care and clinic quality components was analyzed and two factors with an Eigen value greater than 1 were obtained.Results: A total of 846 responses were registered. Factor analysis identified two underlying dimensions: Physician Attitude and Empathy. It was found that the discordance in language between the physician and the patient generates a difference in the perception of satisfaction. Patients who prefer to speak English have better satisfaction than those who speak Spanish. Spanish speakers who do not have a translator have lower satisfaction than those who do. (p<0,01)Conclusions: The most important sociodemographic cofactor was language. Satisfaction decreased in Spanish-speaking patients who were not proficient in the use of English since they expressed fewer comments and doubts. Other associated cofactors were: age, sex, schooling, and occupation.