bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socioeconomic disadvantage and its impact on colorectal cancer in Australia: a scoping review
Authors: Tham Nicole Li , Skandarajah Anita , Hayes Ian Paul 
Published: October 2022

AbstractBackgroundSocial disparities in cancer survival have been demonstrated in Australia despite a universal healthcare insurance system. Colorectal cancer is common, and reasons for survival disparities related to socioeconomic status need to be investigated and addressed. The aim is to evaluate the current Australian literature concerning the impact of socioeconomic status on colorectal cancer survival and stage at presentation.MethodsA systematic search of PUBMED, EMBASE, SCOPUS and Clarivate Web of Science databases from January 2010 to March 2022 was performed. Studies investigating the impact of socioeconomic status on colorectal stage at presentation or survival in Australia were included. Data were extracted on author, year of publication, state or territory of origin, patient population, other exposure variables, outcomes and findings and adjustments made.ResultsOf the 14 articles included, the patient populations examined varied in size from 207 to 100 000+ cases. Evidence that socioeconomic disadvantage was associated with poorer survival was demonstrated in eight of 12 studies. Evidence of effect on late stage at presentation was demonstrated in two of seven studies. Area‐level measures were commonly used to assess socioeconomic status, with varying indices utilized.ConclusionThere is limited evidence that socioeconomic status is associated with late‐stage at presentation. More studies provide evidence of an association between socioeconomic disadvantage and poorer survival, especially larger studies utilizing less clinically‐detailed cancer registry data. Further investigation is required to analyse why socioeconomic disadvantage may be associated with poorer survival.
Sketching local development: Graphic methods at the intersection of democratic and representational experimentalism
Authors: Bertoncin Marina , Pase Andrea , Peterle Giada 
Published: October 2022

AbstractRecent debates on ‘graphic’ geographies and the reinterpretation of the notion of ‘democratic experimentalism’ in local development suggest the rise of a new ‘representational experimentalism’ that explores graphic methods for place‐based approaches. Graphic methods of research can assist geographers in conducting and presenting the results of place‐based research to wider audiences. Graphic products of research function as tools for storytelling and spatial planning. They can also provide intersubjective dialogue between researchers, local communities, and local governments to create more inclusive place‐based narratives. In this paper, we present a verbo‐visual manifesto and an illustrated fieldwork journal as two empirical examples of possible ways to engage with graphic methods and realise the potential graphic outputs of research. These graphic products are the result of a collaboration between geographers, students in Local Development and Sustainable Territorial Development (at the University of Padua), two professional illustrators, and a group of local stakeholders; they used scribing and observational drawing as place‐based graphic methods during a residential seminar at the Po Delta, in north‐eastern Italy. This paper contributes to both recent debates on creative methods in local development and the study of the use graphic and visual methods in geography. It proposes graphic methods as a way for embracing place‐based approaches to local development in peripheral, fragile, and contested areas, making hidden voices visible.
Card or cash? Evidence regarding consumers' cooperative value‐added tax compliance
Authors: Kim Youngrok , Wan Hongyu , Kang Minjo 
Published: October 2022

AbstractCashless payments discourage value‐added tax (VAT) evasion through transaction records; and they essentially require cooperation from consumers and small business owners. As indirect VAT payers, consumers' payment methods decisively influence the final VAT declaration. However, the literature has yet to investigate consumers' collusive VAT evasion. This study uses data from approximately 7300 taxpayers as collected by the National Survey of Tax and Benefit of South Korea to examine the impacts of perceived trust paradigms on consumers' responses to payment methods when small business owners offer discount benefits. The results reveal that perceived trust in government significantly strengthens consumers' cooperative VAT compliance. We also discover that when the discount amounts are higher, trust has a greater impact on cooperative VAT compliance. The study contributes to the tax literature by demonstrating that trust can improve consumers' cooperative VAT compliance.
Does EU and US paediatric legislation improve the authorization availability of medicines for children in other countries?
Authors: Volodina Anna , Shah‐Rohlfs Rupal , Jahn Albrecht 
Published: October 2022

AimFor over 15 years, the pharmaceutical industry has been engaged in developing medicines for children to comply with the European Union (EU) and the United States (US) regulatory requirements. We assessed the authorization availability of these medicines in countries without paediatric regulatory obligations. Special attention was given to the authorization availability of paediatric formulations.MethodsMedicines for children were sampled from the US Food and Drug Administration and European Medicines Agency websites. We carried out systematic content analysis of product information and compared paediatric labelling in Australia, Brazil, Canada, Russia and South Africa with the EU or the US. The authorization availability of paediatric formulations in originator and generic medicines was reviewed. In Kenya, the authorization availability of sampled medicines and paediatric formulations was investigated.ResultsA total of 161 medicines authorized in the EU or the US were sampled. Whilst at least one paediatric indication was found in 70% of the medicines, the EU and US level of authorization was on average 38% in Australia, Brazil, Canada, Russia and South Africa. Paediatric formulations were authorized on average for 40% of originator and 36% of generic medicines. Kenya had the lowest authorization availability of medicines (40%) and formulations (26%).ConclusionsThe authorization availability of novel medicines for children is lower in countries without paediatric regulatory obligations. Paediatric formulations often do not reach other countries if left unregulated, and their generic uptake is low. To increase authorization availability, submission of paediatric development results should become obligatory in each jurisdiction. Policy initiatives to stimulate the introduction of developed formulations should be encouraged.
Primary hyperoxaluria: Comprehensive mutation screening of the disease causing genes and spectrum of disease‐associated pathogenic variants
Authors: Abid Aiysha , Raza Ali , Khan Abdul Rafay , Firasat Sadaf , Shahid Saba , Hashmi Seema , Zafar Mirza Naqi , Sultan Sajid , Khaliq Shagufta , Rizvi Syed Adib‐ul‐Hasan 
Published: October 2022

AbstractThe primary hyperoxalurias are rare disorders of glyoxylate metabolism. Accurate diagnosis is essential for therapeutic and management strategies. We conducted a molecular study on patients suffering from recurrent calcium‐oxalate stones and nephrocalcinosis and screened primary hyperoxaluria causing genes in a large cohort of early‐onset cases. Disease‐associated pathogenic‐variants were defined as missense, nonsense, frameshift‐indels, and splice‐site variants with a reported minor allele frequency <1% in controls. We found pathogenic‐variants in 34% of the cases. Variants in the AGXT gene causing PH‐I were identified in 81% of the mutation positive cases. PH‐II‐associated variants in the GRHPR gene are found in 15% of the pediatric PH‐positive population. Only 3% of the PH‐positive cases have pathogenic‐variants in the HOGA1 gene, responsible to cause PH‐III. A population‐specific AGXT gene variant c.1049G>A; p.Gly350Asp accounts for 22% of the PH‐I‐positive patients. Pathogenicity of the identified variants was evaluated by in‐silico tools and ACMG guidelines. We have devised a rapid and low‐cost approach for the screening of PH by using targeted‐NGS highlighting the importance of an accurate and cost‐effective screening platform. This is the largest study in Pakistani pediatric patients from South‐Asian region that also expands the mutation spectrum of the three known genes.
The constitutional gain‐of‐function variant p.Glu1099Lys in NSD2 is associated with a novel syndrome
Authors: Popp Bernt , Brugger Melanie , Poschmann Sibylle , Bartolomaeus Tobias , Radtke Maximilian , Hentschel Julia , Di Donato Nataliya , Rump Andreas , Gburek‐Augustat Janina , Graf Elisabeth , Wagner Matias , Sorge Ina , Lemke Johannes R , Meitinger Thomas , Abou Jamra Rami , Strehlow Vincent , Brunet Theresa 
Published: October 2022

AbstractNSD2 dimethylates histone H3 at lysine 36 (H3K36me2) and is located in the Wolf‐Hirschhorn syndrome (WHS) critical region. Recent descriptions have delineated loss‐of‐function (LoF) variants in NSD2 with a distinct disorder. The oncogenic missense variant p.Glu1099Lys occurs somatically in leukemia and has a gain‐of‐function (GoF) effect. We describe two individuals carrying p.Glu1099Lys as heterozygous de novo germline variant identified by exome sequencing (ES) of blood DNA and subsequently confirmed in two ectodermal tissues. Clinically, these individuals are characterized by intellectual disability, coarse/ square facial gestalt, abnormalities of the hands, and organomegaly. Public cell lines with NSD2 GoF variants had increased K36me2, DNA promoter methylation, and dysregulated RNA expression. NSD2 GoF caused by p.Glu1099Lys is associated with a novel phenotype different from WHS and Rauch–Steindl syndrome (RAUST).
The impact of implant‐related characteristics on dental implant blooming: An in vitro study
Authors: Tarce Mihai , de Greef Alexander , Lahoud Pierre , de Faria Vasconcelos Karla , Jacobs Reinhilde , Quirynen Marc 
Published: October 2022

AbstractAimTo assess, in vitro, variables potentially influencing implant blooming using a human‐like imaging phantom and 3D‐printed mandibles.Material and MethodsSixty implants were inserted in 3D‐printed mandibles in 26 different configurations in order to examine the impact of implant diameter, presence of a cover screw, implant design/material, implant position, and the presence of additional implants on implant blooming using two cone‐beam computed tomography (CBCT) devices (Accuitomo [ACC] and NewTom [NWT]). Two observers measured the amount of implant blooming in both buccolingual and mesiodistal directions. Inter‐rater agreement and descriptive statistics, grouped by implant characteristic and CBCT device, were calculated.ResultsBoth CBCT devices increased implant diameter (a mean increase of 9.2% and 11.8% for titanium, 20.3% and 24.4% for zirconium, for ACC and NWT, respectively). An increase in implant diameter did not increase the amount of blooming, whereas placing a cover screw did (from 8.0% to 10.9% for ACC, and from 10.0% to 15.6% for NWT). Moreover, implant design, anatomical region, and the presence of another implant also affected the extent of the blooming.ConclusionsDental implants show a clear diameter increase on CBCT, with the effect being more pronounced for zirconium than for titanium implants. Similar effects are likely to occur in the clinical setting, potentially masking nonosseointegration, reducing the dimensions of peri‐implant defects, and/or causing underestimation of the buccal bone thickness.
The regulatory mechanism and therapeutic potential of transcription factor EB in neurodegenerative diseases
Authors: Jiao Fengjuan , Zhou Bojie , Meng Lingyan 
Published: October 2022

AbstractThe autophagy‐lysosomal pathway (ALP) is involved in the degradation of protein aggregates and damaged organelles. Transcription factor EB (TFEB), a major regulator of ALP, has emerged as a leading factor in addressing neurodegenerative disease pathology, including Alzheimer's disease (AD), Parkinson's disease (PD), PolyQ diseases, and Amyotrophic lateral sclerosis (ALS). In this review, we delineate the regulation of TFEB expression and its functions in ALP. Dysfunctions of TFEB and its role in the pathogenesis of several neurodegenerative diseases are reviewed. We summarize the protective effects and molecular mechanisms of some TFEB‐targeted agonists in neurodegenerative diseases. We also offer our perspective on analyzing the pros and cons of these agonists in the treatment of neurodegenerative diseases from the perspective of drug development. More studies on the regulatory mechanisms of TFEB in other biological processes will aid our understanding of the application of TFEB‐targeted therapy in neurodegeneration.
Negative interactions between humans and Asiatic black bears (Ursus thibetanus) in northern Pakistan
Authors: Ali Abid , Uz Zaman Iftikhar , Omer Talha , Ahmad Shakeel , López‐Bao José Vicente 
Published: October 2022

AbstractThe conservation of the vulnerable Asiatic black bear (Ursus thibetanus) in Pakistan is challenged by retaliatory killing, driven by negative interactions between people and bears, such as livestock depredation. We distributed a questionnaire among 369 individuals in rural communities within the Mansehra District, Pakistan, where bear retaliatory killings are often reported. We focused on human–Asiatic black bear negative interactions, such as livestock depredations, crop damage, and human injuries occurring between 2015 and 2019. Although the number of livestock depredation events was small in absolute terms (an average of 11.5 livestock heads reported to be killed annually), it had a large estimated economic impact in terms of local economies ($1367 per year, or a total of $5.469 between 2015 and 2019). Such annual estimated costs account for 93% of the per capita gross domestic product for Pakistan, roughly equivalent to $55,853 for a US citizen. Additionally, 30 incidents between people and bears were registered, where 6% human were fatal. We recommend awareness campaigns on different mitigating interventions, and training on how to use them, as well as behaviors to reduce the risk of negative interactions.
Lipid transfer protein allergy: characterization and comparison to birch‐related food allergy
Authors: Wolters Paula , Ostermann Thomas , Hofmann Silke C. 
Published: October 2022

SummaryBackgroundLipid transfer proteins (LTP) are a frequent elicitor of anaphylaxis to plant‐derived food allergens in southern Europe.Patients and methods15 German patients with LTP allergy were compared to 17 patients with birch‐related food allergy (BRFA) using a detailed anamnesis, serology, skin tests, and the FAQLQ‐AF quality of life questionnaire.ResultsWhile patients with BRFA mainly reacted to tree nuts, and pome and stone fruits, LTP allergic individuals reported vegetables, berry fruits, cereals, and seeds as common additional elicitors. Anaphylaxis was associated with cofactors in 73 % of LTP allergic patients compared to only 6 % in BRFA (P < 0.001). Symptoms occurred delayed by more than one hour in 40 % and were triggered by raw and cooked foodstuffs in 86 % of LTP allergic patients, compared to only 6 % and 41 % of BRFA patients, respectively. A peach prick test was positive in all LTP allergic patients, but only in 15 % of BRFA patients (P < 0.001). Although patients with LTP allergy reported severe anaphylaxis more frequently, quality of life did not differ between groups.ConclusionsAnaphylaxis to plant‐derived foodstuffs warrants assessment by IgE detection to Pru p 3 and skin tests with peach extract, particularly if cofactors and intolerance to heated foodstuffs are related.
Sandy beach dwelling crickets (Orthoptera: Trigonidiidae) have no preference for substrates that match their body color
Authors: Sato Riho , Kuriwada Takashi 
Published: October 2022

ABSTRACTHabitat choice is an important behavior for maximizing fitness. One of the factors involved in habitat choice is preference for habitat substrates. In the context of predatory avoidance, it is adaptive to prefer substrates that are matched to own body color. The ground cricket Dianemobius csikii (Bolívar, 1901) occurs on sandy beaches. The body color of D. csikii resembles the sand of their habitat, which could be a form of crypsis. If D. csikii is not able to choose a suitable habitat background that matches their body color, the crickets incur a high risk of predation. The risk could result in population decline of the cricket. To examine whether D. csikii shows preference for substrates that match its body color, we undertook a two‐choice test of sand or soil substrates after controlling the type of flooring substrates used during rearing. The crickets did not show preference for sand. There was no significant effect of flooring substrates during the nymph stage on the preference. These results suggest that when habitats are fragmented, crickets do not actively choose a cryptic background. There were significant differences in the substrate preference between sexes. These results reflect differences in the reproductive strategies of males and females.
Chaotic spotted hyena optimizer for numerical problems
Authors: Kumar Vijay , Singh Dilbag 
Published: October 2022

AbstractSpotted hyena optimizer (SHO) is a new metaheuristic algorithm that replicates spotted hyenas' hunting and social behaviour. This article proposes novel SHO algorithm that utilizes chaotic maps for fine‐tuning of control parameters. The chaotic maps help SHO to enhance the searching behaviour and preclude the solution to get trapped in local optima. The authors suggest 10 novel chaotic versions of SHO. The algorithms' performance is evaluated using 29 standardized test functions. The finding reveal that some of the presented algorithms outperform the standard SHO in terms of search capability and solution quality. In addition, five competitive approaches are compared with the suggested algorithms. It is observed from the results that chaos‐based spotted hyena optimizer (CSHO) achieved approximately 3% improvement over SHO in terms of fitness value. CSHO is also tested using five engineering design problems. CSHO achieved a 3%–5% improvement over the existing metaheuristic algorithms in terms of optimal design cost. Experimental results reveal that CSHO outperforms the existing metaheuristic algorithms.
Investigating moderators of daily marital to parent–child spillover: Individual and family systems approaches
Authors: Kuo Patty X. , Lee Kejin , Johnson Victoria J. , Starr Emily J. 
Published: October 2022

AbstractObjectiveWe tested whether cognitive reappraisal and coparenting quality moderate marital to parent–child spillover in mothers and fathers.BackgroundThe influence of marital relationship quality on parent–child relationships, referred to as the spillover effect, is well documented. Factors that may attenuate the occurrence of spillover, however, remain unclear. Cognitive reappraisal, an emotion regulation strategy that promotes the reframing of emotional situations as neutral or positive, and coparenting—the intermediate subsystem between the marital and parent–child relationships—may buffer the effects of marital to parent–child spillover.MethodUsing daily diary data from mother–father couples (N = 96) of young children (Mage = 3.22 years), we investigated coparenting quality and cognitive reappraisal as moderators of marital and parent–child spillover within and between days.ResultsDyadic multilevel models revealed within‐day spillover of marital emotional climate and parent–child emotional climate for both mothers and fathers. Whereas cognitive reappraisal moderated spillover for fathers, no significant moderators emerged for mothers. Fathers also experienced next‐day associations between marital emotional climate and parent–child emotional climate the following day, whereas mothers did not. Coparenting quality accounted for next‐day associations between fathers' marital emotional climate and parent–child climate.ConclusionOverall, our results evince that although spillover can be attenuated by both cognitive reappraisal and coparenting quality for fathers, the same is not true for mothers.ImplicationsThese results signify the importance of considering mother and father differences in empirical investigations of spillover effects and processes within the family system, and the clinical implications recommended to marriage and family therapists.
Loss of the world's smallest forests
Authors: Riva Federico , Martin Caroline J. , Millard Koreen , Fahrig Lenore 
Published: October 2022

AbstractA large number of small forests typically harbor higher biodiversity than a small number of large forests totaling the same area, suggesting that small patches are disproportionately valuable for biodiversity conservation. However, policies often favor protection of large forest patches. Here we demonstrate a global trend of higher deforestation in small than large forest patches: the likelihood that a randomly selected forest plot disappeared between 1992 and 2020 increased with decreasing size of the forest patch containing that plot. Our results imply a disproportionate impact of forest loss on biodiversity relative to the total forest area removed. Achieving recent commitments of the post‐2020 Global Biodiversity Framework will require revision of current policies and increased societal awareness of the importance of small habitat patches for biodiversity protection.
Immunomodulatory effect of IL‐1RA in LPS‐activated macrophage/dental pulp stem cells co‐culture
Authors: Gopinath Vellore Kannan , Mohammad Mohammad G. , Sheela Soumya 
Published: October 2022

AbstractAimsLipopolysaccharides (LPS)‐activated human dental pulp stem cells (hDPSCs) and macrophage co‐cultures showed downregulated TNF‐α secretion that is modulated by hDPSCs through IDO axis, whereas the secretory levels of IL‐1β remained unchanged. Therefore, sustained production of IL‐1β could contribute to progressive dental pulp inflammation. However, the role of interleukin‐1 receptor antagonist (IL‐1RA) in downregulating the secretion of IL‐1β and TNF‐α in LPS‐activated M0/M1/M2 macrophage and hDPSCs co‐culture has not been studied yet. Therefore, the aim of the present study was to determine the immunomodulatory role of blocking IL‐1 receptors in DPSCs macrophage co‐culture activated with LPS.MethodologyHuman monocytic cell line THP‐1 was polarized to M0, M1 and M2 macrophages and co‐cultured with hDPSCs. The viability of the co‐cultured cells was assessed by apoptosis assay. Co‐cultures were activated with LPS followed by the assessment of gene expression and protein levels of IL‐1β and TNF‐α with and without IL‐1RA blocking via qRT‐PCR and cytokine flex assay by flow cytometry. Data from three separate experiments were analysed using one‐way anova followed by Tukey's post hoc test and a p‐value of <.05 was considered statistically significant.ResultsTHP‐1‐derived M0, M1 and M2 macrophages co‐cultured with hDPSCs showed spindle and round‐shaped cells, with >90% viability when assessed by apoptosis assay. Inflammatory TNF‐α and IL‐1β profiles in stimulated co‐cultures showed upregulated IL‐1β, whereas TNF‐α was downregulated (p < .05). Anti‐inflammatory gene expression levels of IL‐10 and TGF‐β were downregulated (p < .05). Blocking with IL‐1RA resulted in a remarkable decrease in IL‐1β at the gene expression and protein production levels whilst TNF‐α levels remained low (p < .05). Levels of anti‐inflammatory cytokine IL‐10 showed no significant difference.ConclusionBlocking the IL‐1 receptor in hDPSCs and macrophage (M0, M1, M2) co‐cultures activated with LPS resulted in downregulation of inflammatory cytokines IL‐1β and TNF‐α. These findings highlight the immunomodulatory effect of IL‐1RA in inflammatory conditions of dental pulp infections.