bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal and Neonatal Morbidity and Mortality Among Pregnant Women With and Without COVID-19 Infection: The INTERCOVID Multinational Cohort Study
Authors: Villar José , Ariff Shabina , Gunier Robert B. , Thiruvengadam Ramachandran , Rauch Stephen , Kholin Alexey , Roggero Paola , Prefumo Federico , do Vale Marynéa Silva , Cardona-Perez Jorge Arturo , Maiz Nerea , Cetin Irene , Savasi Valeria , Deruelle Philippe , Easter Sarah Rae , Sichitiu Joanna , Soto Conti Constanza P. , Ernawati Ernawati , Mhatre Mohak , Teji Jagjit Singh , Liu Becky , Capelli Carola , Oberto Manuela , Salazar Laura , Gravett Michael G. , Cavoretto Paolo Ivo , Nachinab Vincent Bizor , Galadanci Hadiza , Oros Daniel , Ayede Adejumoke Idowu , Sentilhes Loïc , Bako Babagana , Savorani Mónica , Cena Hellas , García-May Perla K. , Etuk Saturday , Casale Roberto , Abd-Elsalam Sherief , Ikenoue Satoru , Aminu Muhammad Baffah , Vecciarelli Carmen , Duro Eduardo A. , Usman Mustapha Ado , John-Akinola Yetunde , Nieto Ricardo , Ferrazi Enrico , Bhutta Zulfiqar A. , Langer Ana , Kennedy Stephen H. , Papageorghiou Aris T. 
Published: February 2022

(Abstracted from JAMA Pediatr 2021;175:817–826)
At the beginning of the COVID-19 pandemic, the extent of the risks of a COVID infection during pregnancy were unknown. During the start of the pandemic, there were only a few studies published comparing outcomes between pregnant women with and without COVID-19 infections.
The Computations of a Traumatized Mind: A Latent Cause Model of Posttraumatic Stress Disorder
Authors: Rigoli Francesco 
Published: February 2022

Abstract
In cognitive psychology, a recent perspective based on the notion of latent cause (LC) has offered new insight on how learning and memory work. Here I explore the implications of this novel perspective to understand posttraumatic stress disorder (PTSD). The proposal is that, because of a propensity to interpret events as manifestations of multiple LCs (a propensity facilitated by experiencing traumas in childhood), PTSD patients form an LC associated with the trauma and that this LC is responsible for typical symptoms of the illness (specifically, intrusive symptoms and associated fear). Later, after the trauma, some patients develop a second LC, now associated with the presence of trauma-related cues combined with absence of danger. Development of the latter LC would interfere with extinction and explain why, for some patients, exposure to trauma-related cues (even when supported by interventions such as exposure protocols) fails to provide much improvement. This proposal has potential clinical implications, raising the possibility that some patients might benefit from exposure to mildly painful aspects of the trauma in conjunction with trauma-related cues.
Q Fever Masquerading as Legionnaires Disease in an Endovascular Stent Infection
Authors: Hynes Allyson M. , O'Donnell Judith A. , Aly Ahmed H. , Blackstock Christopher D. , Kalapatapu Venkat R. , Martin Niels D. 
Published: February 2022

Abstract

Background
Legionellosis in the setting of preexisting endovascular prosthetic graft may represent a Coxiella burnetii infection as antibody cross-reactivity exists.

Methods
We present a 63-year-old man status-post endovascular aneurysm repair (EVAR) with a history of ankylosing spondylitis, chronic obstructive pulmonary disease asthma, coronary artery disease with myocardial infarction, hypertension, and hyperlipidemia who presented with clinical symptoms of legionellosis. This was confirmed with a positive urine antigen test.

Results
He completed a 21-day course of azithromycin for Legionella. His leukocytosis and liver function tests normalized, but he had continued lethargy and a persistently elevated erythrocyte sedimentation rate and C-reactive protein. Imaging showed a radiographically infected EVAR graft (placed 10 months prior). The EVAR was explanted and the operating room cultures grew C. burnetii. Prolonged hydroxychloroquine and doxycycline therapy were required for vascular manifestations of Coxiella as azithromycin provides inappropriate coverage.

Conclusions
Persistent constitutional symptoms in the setting of an EVAR require expanded investigation, especially in the setting of legionellosis.
Edwardsiella tarda Bacteremia With Tubo-Ovarian Abscess
Authors: Gardner Austin B. , Dunn Timothy N. , White Cameron M. , Franco Ricardo , Buenaventura Sofia , Boozer Margaret 
Published: February 2022

Abstract

Edwardsiella tarda infection is infrequently encountered in humans. Exposure most often occurs through consumption of raw seafood or activities in bodies of fresh or brackish water, and systemic infections can have a high mortality rate. We present the case of a 32-year-old woman who presented with abdominal pain, nausea, vomiting, and diarrhea. She was septic and was started on broad-spectrum antibiotics after cultures were drawn. Imaging showed pyosalpinx/tubo-ovarian abscess that was refractory to systemic antibiotics and ultimately required surgical management. Two blood cultures and an intraoperative abscess culture grew pan-susceptible E. tarda. Postoperatively, the patient's clinical status quickly improved, and she was doing well at her follow-up visit. To the best of our knowledge, cases of E. tarda bacteremia in the setting of tubo-ovarian abscess have not previously been reported, and this case is particularly unusual in that the patient is young and without predisposing chronic medical conditions.
Life-Threatening Capnocytophaga canimorsus Sepsis Associated With Ustekinumab Use for Psoriatic Arthritis
Authors: Holtzapple Zachary , Ellis Wilfred J. G. 
Published: February 2022

Abstract

Capnocytophage canimorsus is a gram-negative rod bacterium that composes the microbial biome in the oral cavity of some canines and felines. It is mostly seen in patients with underlying disorder such as asplenia, general alcohol abuse, and cirrhosis. It can lead to multiple complications for patients that include meningitis, endocarditis, and sepsis. The history and the broad differential are important details for clinicians because of its slow-growing nature during blood culturing. Broad-spectrum antibiotics and life support are considered the mainstays of treatment for a patient presenting with unknown sepsis that may be caused by C. canimorsus. The authors present the risk factors, clinical picture, and treatment for the encounter of a patient with sepsis secondary to C. canimorsus.
Vestibular Rehabilitation Therapy for the Treatment of Vestibular Migraine, and the Impact of Traumatic Brain Injury on Outcome: A Retrospective Study
Authors: Stancel-Lewis Jack , Lau Joanne Wai Ling , Male Amanda , Korres George , Rogel-Salazar Jesus , Pavlou Marousa , Bamiou Doris-Eva 
Published: February 2022

Introduction:
Vestibular migraine (VM) is a common condition; individuals experience dizziness with migraine symptoms. Vestibular rehabilitation therapy (VRT) has been reported as an effective treatment for VM, however, evidence is limited. VM and traumatic brain injury (TBI) can co-occur, and some suggest that TBI can induce VM. There is limited evidence on the effect a history of TBI has on VRT in patients with VM.

Methods:
Retrospective case series of 93 (f = 63, m = 30) participants with VM and underwent VRT (mean age 48.62; SD 15.92). Pre- and post-treatment self-reported outcome measures and functional gait assessment were extracted from the participants health records and evaluated. The impact of TBI on VRT outcome in participants with VM was analyzed. Individuals with TBI and no history of migraine (n = 40) were also extracted to act as a control.

Results:
VRT significantly improved self-reported dizziness on the Dizziness Handicap Inventory (DHI), with a mean change of –18 points (p < 0.000) and +5 points on the functional gait assessment (FGA) (p < 0.000) in patients with VM. A history of TBI significantly impacted outcome on the DHI (p = 0.018) in patients with VM.
VRT significantly improved all outcome measures for individuals with TBI, with a mean change of –16 points on the DHI (p = 0.001) and +5 points on the FGA (p < 0.000). VM presence significantly impacted outcome.

Conclusion:
VRT should be considered as a treatment option to reduce dizziness and the risk of falls in individuals with VM. TBI may negatively impact VRT outcomes in individuals with VM.
The effects of target-controlled infusion of lidocaine undergoing vocal cord polypectomy
Authors: Zhou LongYuan , Wu RuiLan , Cai Chang , Qi Yong , Bi XingHua , Hang Qi 
Published: February 2022

Abstract

Background:
The present study aimed to assess the efficacy and safety of general anesthesia-assisted target-controlled plasma infusion of lidocaine in patients with vocal cord polypectomy using a supporting laryngoscope.

Methods:
In total, 80 patients undergoing vocal cord polypectomy using a supporting laryngoscope were randomly divided into an intervention group and a control group; each group contained 40 subjects: both groups received general anesthesia; subjects in the intervention also received an additional 3 mg/L of lidocaine by target-controlled plasma infusion during induction and maintenance of anesthesia; heart rate (HR) mean arterial pressure (MAP), propofol and urapidil consumption (Uradil, which is a blood pressure drug that blocks alpha-1, is called Urapidi Hydrochloride Injection. It is produced by Germany, the enterprise name is Nycomed Deutschland GmbH, the import drug registration number is H20090715, and it is widely used in China), recovery time, and cough score (measured by Minogue et al's 5-grade scoring method) during extubation, and throat pain score (measured by visual analogue scale,[VAS]) after extubation and adverse events were recorded.

Results:
Significant differences were observed in HR (P < .05) and MAP (P < .05) immediately after intubation (T2), immediately after the operation starting to support laryngoscope exposure (T3), immediately after operation field adrenergic tampon hemostasis (T4), and 5 minutes after hemostasis (T5) between the 2 groups, and significant differences were also observed in HR (P < .05) before intubation (T1). Moreover, significant differences were observed in propofol consumption (P < .05), urapidil consumption (P < .05), cough score during extubation (P < .05), and throat pain score after extubation (P < .05). However, no significant difference was observed in the recovery time (P > .05). Furthermore, no adverse events were detected in either group.

Conclusion:
The results of this study showed that target-controlled plasma infusion of lidocaine can reduce propofol consumption in patients undergoing vocal cord polypectomy by supporting laryngoscopy, and the hemodynamics are more stable and reduce the coughing reaction in the wake period and throat pain after extubation without adverse events.
Global trends of researches on bone metastasis
Authors: Huang Kai 
Published: February 2022

Abstract

Background:
Bone metastasis (BM) has become an important health problem. In recent years, studies on BM are growing rapidly, but there were no bibliometric studies regarding BM. This study aimed to illustrate the overall knowledge structure and development trends of BM.

Methods:
Research datasets were acquired from the Web of Science database. The time span was defined as “1980–2020”. VOS viewer and Citespace software was provided to analyze the data and generate visualization knowledge maps. Annual trends of publications, distribution, H-index status, co-authorship status, and research hotspots were analyzed.

Results:
Six hundred eighty-two publications met the requirement. USA published most papers (264, 38.7%), and both total citations (13,997) and H-index (57) of USA ranked first. The most productive institution on BM is Amgen Inc. (43). Supportive Care in Cancer (24) published the most papers on BM. “Safety”, “skeletal related event”, “open label”, “management”, “health”, and “prognosis” are the research hotspots in the recent years.

Conclusion:
In this study, we conduct a systematic and comprehensive analysis on the research in BM field. The publication number was rising in recent years stably. USA contributed mostly not only in quality, but also in quantity. Amgen Inc. published the largest number of articles, Supportive Care in Cancer was the most productive journal related to BM. “Safety”, “skeletal related event”, “open label”, “management”, “health”, and “prognosis” are the research hotspots in recent years. We believe this study can not only show the global research overview in past 40 years but also point the research trend of BM in the future.
Effects of vitamin D supplementation on ovarian reserve markers in infertile women with diminished ovarian reserve
Authors: Bacanakgil Besim Haluk , İlhan Gülşah , Ohanoğlu Karolin 
Published: February 2022

Abstract
The purpose of this study was to evaluate the effects of vitamin D supplementation on ovarian reserve markers, including serum anti-Mullerian hormone (AMH) level, follicle-stimulating hormone (FSH) level, and antral follicle count (AFC), in infertile women with diminished ovarian reserve and vitamin D deficiency.
A prospective, nonrandomized, cross-sectional study was conducted. Women aged 18 to 41 years who were unable to become pregnant after 12 months of sexual intercourse and had normal tubal patency, partners with normal semen analysis, diminished ovarian reserve, and 25-hydroxyvitamin D [25(OH)D] deficiency were included. Eligible patients’ AFC and serum levels of AMH, FSH, 25(OH)D, 1,25-dihydroxyvitamin D [1,25(OH)D], calcium, phosphate, alkaline phosphatase, and parathormone were assessed before and after administration of 300,000 IU of vitamin D ampules. Changes in the parameter values after vitamin D supplementation were compared with the initial levels.
The study was conducted in 62 of the 142 participants. The AFC and AMH, 25(OH)D, 1,25(OH)D, phosphate (P < .01), and calcium levels (P < .05) were statistically significantly increased after vitamin D supplementation. Statistically significant decreases in FSH (P < .01) and alkaline phosphatase levels (P < .05) were observed after vitamin D supplementation. No statistically significant correlations were found between 25(OH)D level and AFC, 1,25(OH)D level, AMH level, and FSH level before and after supplementation (P > .05).
As improvements in the ovarian reserve markers were obtained with vitamin D supplementation, vitamin D might be considered as a fertility treatment for patients with diminished ovarian reserve and vitamin D deficiency.
Expression and prognostic impact of CD49b in human lung cancer
Authors: Tirilomi Anna , Elakad Omar , Yao Sha , Li Yuchan , Hinterthaner Marc , Danner Bernhard C. , Ströbel Philipp , Tirilomis Theodor , Bohnenberger Hanibal , von Hammerstein-Equord Alexander 
Published: February 2022

Abstract
Lung cancer remains the worldwide leading cause of cancer-related death. Currently, prognostic biomarkers for the detection and stratification of lung cancer are being investigated for clinical use. The surface protein cluster of differentiation 49b (CD49b) plays an important role in promoting cell proliferation and invasion in different tumor entities and blocking CD49b improved the tumor immune response. Overexpression of CD49b has been associated with unfavorable survival rates in several malignant tumor entities, such as prostate cancer, gastric cancer and colon cancer. Therefore, we aimed to analyze the protein expression of CD49b in patients with different types of lung cancer and additionally to identify the influence of CD49b on clinicopathological characteristics and overall survival.
Expression levels of CD49b were retrospective analyzed by immunohistochemistry in 92 cases of pulmonary adenocarcinoma (AC), 85 cases of squamous cell lung carcinoma (SQCLC) and 32 cases of small cell lung cancer (SCLC) and correlated with clinicopathological characteristics and patients’ overall survival.
A strong expression of CD49b was most seen in SQCLC (78%), followed by AC (48%) and SCLC (9%). All patients combined, strong expression of CD49b correlated significantly with poorer overall survival. However, an increased expression of CD49b correlated significantly with a poorer survival rate only in SQCLC. In AC and SCLC, no significant correlation could be demonstrated in this regard.
In our study, CD49b expression was associated with poor overall survival in patients with SQCLC. Accordingly, CD49b could serve as a new prognostic biomarker and, moreover, be a potential new drug target in SQCLC.
Barriers and Facilitators to Success in Undergraduate Nursing Education Among Minority Students
Authors: Osakwe Zainab Toteh , Obioha Chinedu U. , Minuti Aurelia , Atairu Minne , Osborne Jennel C. 
Published: February 2022

Background:
Underrepresented minority (URM) students in nursing education are essential to address health disparities.

Purpose:
To determine barriers and facilitators to success among URM students in nursing education.

Methods:
CINAHL, PubMed, Embase, and PsycINFO were searched for English language research studies published between 1980 and 2020, which focused on barriers and facilitators to success in nursing education in the United States among URM students. Using PRISMA guidelines, 2 reviewers independently reviewed and appraised the quality of relevant articles.

Results:
Among the 4435 articles surveyed, 14 met inclusion criteria. Most studies were focused on Black and Hispanic/Latinx students, and 71% were qualitative. Barriers included social isolation, caregiving demands, lack of mentorship, and inadequate financial resources. Facilitators included mentorship, positive class and curriculum, family support, financial support, and diverse/inclusive learning environments.

Conclusions:
URM students face complex barriers to success in nursing education. Addressing these barriers requires a multilevel approach.
Assessment of Adult Women With Ovarian Masses and Treatment of Epithelial Ovarian Cancer: ASCO Resource-Stratified Guideline
Authors: Vanderpuye Verna D. , Clemenceau Jean Rene V. , Temin Sarah , Aziz Zeba , Burke William M. , Cevallos Nixon Leonardo , Chuang Linus T. , Colgan Terence J. , del Carmen Marcela G. , Fujiwara Keiichi , Kohn Elise C. , Nogales Jose Enrique Gonzáles , Konney Thomas Okpoti , Mukhopadhyay Asima , Paudel Bishnu D. , Tóth Icó , Wilailak Sarikapan , Ghebre Rahel G. 
Published: February 2022

(Abstracted from JCO Glob Oncol 2021;7:1032–1066)
The lack of reliable screening modalities for ovarian cancer results in most women being diagnosed on the basis of symptomatic presentation with the majority at advanced stages. Nonspecific symptoms may be overlooked or misdiagnosed regardless of how resource-rich the health care system.
Retrograde Bladder Filling After Outpatient Gynecologic Surgery: A Systematic Review and Meta-Analysis
Authors: Thiel Peter S. , Mathur Siddhi , Zakhari Andrew , Matelski John , Walsh Chris , Murji Ally 
Published: February 2022

(Abstracted from Obstet Gynecol 2021;138:647–654)
The potential for impaired bladder function after outpatient or inpatient gynecologic surgery has led many centers to require a successful voiding trial before discharge. Partially retrofilling the bladder has been investigated in various gynecologic surgery populations to reduce time spent waiting for passive filling.
Immunosuppression and SARS-CoV-2 Infection in Kidney Transplant Recipients
Authors: Devresse Arnaud , De Greef Julien , Yombi Jean Cyr , Belkhir Leila , Goffin Eric , Kanaan Nada 
Published: February 2022

Kidney transplant recipients (KTRs) infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have an increased risk of mortality compared with the general population and hemodialysis patients. As these patients are immunosuppressed, it might seem obvious to attribute this excess mortality to the impaired immunity induced by immunosuppression. In line with this reasoning is the low immune response, both cellular and humoral, that KTRs mount in response to the anti–SARS-CoV-2 vaccine; however, acute respiratory distress syndrome associated with coronavirus disease 2019 is triggered by a state of inflammation and cytokine release syndrome that lead to pulmonary damage and increased mortality. In that context, immunosuppressive treatment dampening the immune response could, in theory, be potentially beneficial.
This review aims at analyzing the current knowledge on the impact of immunosuppressive treatment on mortality in SARS-CoV-2–infected KTRs, the optimal management of immunosuppression in the coronavirus disease 2019 era, and the vaccine response and management in immunosuppressed KTRs.
The Practice of Retransplantation for Recurrent Alcohol-associated Liver Disease in the United States Is Uncommon With Acceptable Outcomes
Authors: Cotter Thomas G. , Odenwald Matthew A. , Lieber Sarah R. , Rich Nicole E. , Im Gene , Charlton Michael , Singal Amit G. , Mitchell Mack C. 
Published: February 2022

Background.
Alcohol-associated liver disease (ALD) is the leading indication for liver transplantation (LT) in the United States. Alcohol use disorder relapse can lead to graft failure and the need for liver retransplantation (re-LT). Despite the rising incidence of LT for ALD, the practice of re-LT for recurrent ALD is not well understood. We aimed to define the practice of re-LT for recurrent ALD during the last 20 y.

Methods.
Using the US national transplant registry, adults who underwent re-LT for recurrent ALD were compared with LT recipients who died from recurrent ALD and propensity score–matched re-LT recipients with non-ALD indications. All groups had at least 1-y survival of their primary graft. Kaplan-Meier analysis was used to calculate 1- and 5-y survivals.

Results.
Between 2000 and 2020, 74 re-LTs were performed for recurrent ALD (1.0% of all re-LTs). There was an increase in recurrent ALD re-LT practice from 2017 to 2020 versus 2014 to 2016 (20 versus 2). At the time of re-LT, patients with recurrent ALD had a significant decrease in body mass index (median 25.1 versus 28.8 kg/m2; P < 0.001) versus the index LT. Patient and graft survivals were similar between patients who underwent re-LT for ALD and non-ALD (56.4% versus 56.9% 5-y graft survival, P = 0.96; 62.8% versus 59.0% 5-y patient survival, P = 0.58).

Conclusions.
The practice of re-LT for recurrent ALD is uncommon in the United States. Graft and patient survivals seem to be acceptable and support the occasional practice of re-LT for recurrent ALD should the patient be deemed an appropriate candidate.
Chronic Intermittent Hypobaric Hypoxia Prevents Contrast-Induced Acute Kidney Injury By Modulating The HIF-1α Signaling Pathway
Authors: Yin Kai-min , Ni Yan-hui , Cao Guang-yun , Zhang Jia-yuan , Yi Bao-jun , Pang Zi-hao , Ma Hui-jie , Zhang Li 
Published: February 2022

AbstractThe aim of this study was to explore the role of CIHH in preventing contrast-induced acute kidney injury (CI-AKI) in rats and its mechanism. Rats mean arterial pressure, heart rate, serum creatinine and blood urea nitrogen levels were measured. The kidney tissue pathological changes, superoxide dismutase (SOD) activity, malondialdehyde (MDA) levels, hypoxia inducible factor-1α, Bcl-2/adenovirus E1B-19kDa-interacting protein3 (BNIP3) , cysteiny aspartate specific protease3(caspase3) and poly(ADP-ribose) polymerase (PARP) expression levels were testing. The results showed that CIHH prevented CI-AKI group mean arterial pressure, heart rate, serum creatinine and blood urea nitrogen levels were reduced, kidney tissue SOD activity was increased, MDA levels was reduced, HIF-1α,BNIP3,caspase3 and PARP levels were increased than the CI-AKI group. This study indicates that CIHH pretreatment may have a protective effect on contrast-induced early kidney injury by activating the HIF-1α/BNIP3 signaling pathway to regulate mitochondrial autophagy and enhance cellular anti-apoptotic and renal antioxidant capacity, for the first time.