bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation analysis of TGF-β1, MMP-9, TIMP-1, IL-1, IL-4, IL-6, IL-17, and TNF-α in refractory chronic rhinosinusitis: A retrospective study
Authors: Wen Wulin , Zhu Simin , Ma Ruixia , Wang Lixin , Shen Xueliang , Li Yongchun , Feng Ningyu , Wang Le , Liu Ming , Xie Lina , Zhang Xueqiang 
Published: July 2022

Objective: To investigate the potential correlation of transforming growth factor-β (TGF-β), matrix metalloprotein 9 (MMP-9), tissue inhibitor of metalloproteinases 1 (TIMP-1), Interleukin 1 (IL-1), IL-4, IL-6, IL-17, and tumor necrosis factor alpha (TNF-α) in refractory chronic rhinosinusitis.
Methods: A total of 150 participants were retrospectively included in this study from August 2018 to February 2020. The people enrolled were equally allocated into refractory group (patients with refractory chronic rhinosinusitis), chronic group (patients with chronic rhinosinusitis), and control group (normal people). The level of TGF-β1, MMP-9, TIMP-1, IL-1, IL-4, IL-6, IL-17, and TNF-α were recorded. The unconditional multivariate binary logistic regression was used to analyze the factors affecting refractory chronic rhinosinusitis.
Results: The Davos score, T&T olfactometer threshold test, and Lund-Mackay CT scores in refractory group were significantly higher than the chronic group (P<0.05). The level of TGF-β1, MMP-9, TIMP-1, IL-1, IL-4, IL-6, IL-17, and TNF-α in the refractory group were significantly higher than the chronic group and the control group (all P<0.05). Similarly, the level of the above mentioned indexes in the chronic group were significantly higher than the control group (P<0.05). The Davos score, T&T olfactometer threshold test score, Lund-Mackay CT score, and the level of TGF-β1, MMP-9, TIMP-1, IL-1, IL-4, IL-6, IL-17, and TNF-α positively correlated with refractory chronic rhinosinusitis. Moreover, the unconditional multivariate binary logistic regression showed that the influencing factors of refractory chronic rhinosinusitis included TGF-β1, MMP-9, TIMP-1, IL-1, IL-4, IL-6, IL-17, and TNF-α.
Conclusion: The findings of the present study provide evidence for TGF-β1, MMP-9, TIMP-1, IL-4, IL-6, IL-17, and TNF-α as the influencing factors of refractory chronic rhinosinusitis.
Modelling microalgae biofouling on porous buildings materials: a novel approach
Authors: Quagliarini Enrico , Gregorini Benedetta , D’Orazio Marco 
Published: July 2022

AbstractA correct assessment of microalgae growth on porous building materials (i.e.: fired bricks, sandstones and limestones) can provide a useful tool for researchers and practitioners. In fact, it may help predicting the biofouling damage extension and it can assist the experts in a correct planning of maintenance interventions to limit costs. The literature regarding such issue outlined the Avrami’s model as the most recurrent one, even considering the influence of biocidal treatments on the substrate. However, it seems to have some limitations when the growth is very fast or, conversely, when the latency time is extended over the time. Therefore, a different modelling approach is here proposed, by using the logistic function (extensively used i.e. in population growth). Results reveal that the logistic function seems to succeed in better modelling the available experimental data. Moreover, it seems to overcome the limits of the Avrami’s model, as well as to be less influenced by the main drivers of microalgae growth, such as porosity and roughness of the substrate, biocides treatments and environmental conditions (temperature).
Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy
Authors: Gao Shuang , Cui Zhao , Zhao Ming-hui 
Published: July 2022

Significance Statement
Membranous nephropathy (MN) is the leading cause of adult nephrotic syndrome, in which the complement system is highly activated. This paper describes the discovery that the C3a/C3aR pathway is a crucial effector of complement-mediated podocyte injuries in MN. Levels of plasma C3a and glomerular C3aR are elevated in patients with MN compared with healthy controls and are associated with severity and prognosis. In vitro, C3a from MN patients’ plasma damages the physiologic function and cellular activity of podocytes, which C3aR antagonists block. In vivo, C3aR antagonists can also attenuate renal injuries of Heymann nephritis (a classic disease model of MN) rats. Collectively, C3aR blockade may be a potentially viable treatment for this disease.

Background
The complement system is highly activated in primary membranous nephropathy (MN). Identifying the complement components that damage podocytes has important therapeutic implications. This study investigated the role of C3a and the C3a receptor (C3aR) in the pathogenesis of MN.

Methods
C3aR expression in kidneys and circulating levels of C3a of MN patients were examined. Human podocyte damage was assessed after exposure to MN plasma +/− C3aR blockade (SB290157, JR14a). C3aR antagonists were administered to rats with Heymann nephritis on day 0 or after proteinuria. Clinical and pathologic parameters, specific IgG and complement activation, and podocyte injuries were then assessed.

Results
In the glomeruli, C3aR staining merged well with podocin. Overexpression of C3aR correlated positively with proteinuria, serum creatinine, and no response to treatments. Human podocytes exposed to MN plasma showed increased expression of PLA2R, C3aR, and Wnt3/β-catenin, reduced expression of synaptopodin and migration function, downregulated Bcl-2, and decreased cell viability. C3aR antagonists could block these effects. In Heymann nephritis rats, C3aR blockade attenuated proteinuria, electron-dense deposition, foot process width, and glomerular basement membrane thickening in glomeruli. The increased plasma C3a levels and overexpression of C3aR were also alleviated. Specific, but not total, IgG levels decreased, with less deposition of rat IgG in glomeruli and subsequent reduction of C1q, factor B, and C5b-9.

Conclusion
C3a anaphylatoxin is a crucial effector of complement-mediated podocyte damage in MN. The C3aR antagonist may be a potentially viable treatment for this disease.
Budaya Literasi untuk Menumbuhkan Minat Membaca dan Menulis
Authors: Jatnika Shiva Ardenia 
Published: July 2022

Abstract This writing aims to find out how the role of literacy culture in community life in the modern era today will continue to erode with the development of tecnology. Literacy culture itself has a relationship in fostering interest in reading and writing for children in elementary schools. In growing interest in reading and writing, literacy culture is the most important key in realizing this interest. In the results to foster interest in reading and writing, it must require several roles such as infrastructure in schools, communities and parents. If the role is not sufficient, it will have a negative impact on the ongoing culture of literacy. AbstrakPenulisan ini bertujuan untuk mengetahui bagaimana peran budaya literasi dalam kehidupan bermasyarakat pada era modern saat ini yang akan terus tergerus dengan adanya perkembangan tenologi. Budaya literasi sendiri mempunyai hubungan dalam menumbuhkan minat membaca dan menulis terhadap anak di Sekolah Dasar. Dalam menumbuhkan minat membaca dan menulis, budaya literasi merupakan kunci terpenting dalam terealisasinya minat tersebut. Dalam hasilnya untuk menumbuhkan minat membaca dan menulis ini, harus membutuhkan beberapa peran seperti, sarana prasarana dalam sekolah, masyarakat dan orang tua. Apabila peranan tersebut kurang memadahi maka akan berdampak buruk terhadap berlangsungnya budaya literasi yang baik.
#FromTheArchives: An Assessment of a Successful Social Media Program in an Academic Archives
Authors: Weaver Robert G. 
Published: July 2022

ABSTRACT
Academic archives can seem intimidating to the public at large. Accessing and enjoying their contents is, for some, a foreign experience. Even when archives leverage extensive fiscal and technological resources to make their materials available as well-organized, online digital collections, this perception often persists. In 2013, the Southwest Collection/Special Collections Library (SWC) at Texas Tech University (TTU) began an extensive Web 2.0 outreach program designed to overcome that perception for researchers other than TTU students and faculty. Using social media allowed the SWC to creatively and successfully rethink and reframe connections to the nonresearcher public. This article identifies the origin and breadth of that success by walking through the implementation of a comprehensive social media outreach program and providing a qualitative and quantitative assessment of its success, with an eye toward how the SWC and other archives might reframe the use of social media in the future.
“It's a Trap”: Complicating Representation in Community-Based Archives
Authors: Gabiola Joyce , Brilmyer Gracen , Caswell Michelle , Zavala Jimmy 
Published: July 2022

ABSTRACT
This article contributes to ongoing discourse that highlights oppressive institutional attitudes and approaches toward archiving materials that document the lived experiences of historically marginalized and minoritized people and communities. Through analyzing focus groups and interviews with members of minoritized communities about community archives, this article outlines four key tensions that exist around representation: holding conflicting desires of how to honor older generations; navigating methods of respecting privacy and cultural values; acknowledging the importance of preserving community history versus individual histories; and developing strategies for protecting the community. Together, these tensions illustrate the nuances of representation in archives: how members of minoritized communities navigate complex, often conflicting, affects within archival materials and how they protect themselves and future generations through visibility and invisibility. The authors introduce the concept of representational subversion, which they define as the ways in which historically minoritized communities balance and respect both their representation and erasure in society and archives, working through the tensions of honor, cultural nuance, individual value, and community protection. Representational subversion emerges among minoritized people/communities when they use their agency to protect themselves and the communities in which they find a sense of belonging. In explicating four tensions that mark representational subversion, the authors acknowledge a minoritized community's rights to be forgotten/forget (alongside their right to be remembered), to self-preservation, and to self-determination, and demonstrate the reach and perpetual threat of white supremacy in archives.
La narrativa como proceso identitario e innovador en la docencia
Authors: Gomez Martinez Ruben 
Published: July 2022

Valorar las condiciones de incorporación al proceso de formación docente, obliga al reconocimiento de las experiencias vividas en narraciones elaboradas por los protagonistas, quienes a través de autobiografías describen los momentos significativos que inclinaron su preferencia hacia la docencia.Conocer los motivos que invitan a ser docente permite al formador de profesores seleccionar los procesos formativos que propicien dentro del ejercicio profesional incidir en el desarrollo de una identidad, acción que irremediablemente tiene que ver con el otro, con el asesor, con el compañero, con las materias que se cursan, con las prácticas docentes que se realizan y en ellas con los alumnos, con el contenido de la materia, con las metodologías, con el espacio físico, con los miedos, con los éxitos y frustraciones, con el desconocido origen de llegada y con el futuro incierto.A este panorama se requiere agregar además las exigencias y retos que plantea la sociedad y la política educativa en función de que los asesores del futuro docente visualicen el tipo de educador que se requiere y construyan estrategias, proyectos y/o programas educativos que incidan en el desarrollo de una identidad profesional guiando aspectos relacionados con: la conciencia acerca de su rol individual y colectivo, de su misión, de sus metas en relación con la historia global y colectiva. Se trata de que el formador tenga conciencia que de las características que imprima a la integración del profesional de la educación está incidiendo en el destino trascendente, el futuro profesor proyecta su horizonte de vida, dentro de una colectividad y desde sus posibilidades.
Kesiapsiagaan Masyarakat Kota Cilegon dalam Menghadapi Bencana Gempa Bumi dan Tsunami
Authors: Maulida Lisa , Ocktadinata Robbi , Adhayanti Baety 
Published: July 2022

Disaster preparedness is an important matter, especially for people living in disaster-prone areas. Cilegon City has a high risk of earthquake and tsunami disasters. The purpose of this study was to determine the level of community preparedness in the city of Cilegon in facing the earthquake and tsunami disasters. This research is a descriptive study with a cross-sectional approach. The sampling technique used was cluster sampling in the Kelurahan so that five Kelurahan were selected. One hundred respondents from five Kelurahan were taken consecutively. The data collection technique uses the LIPI-Unesco 2006 questionnaire, which consists of 38 statement items of five parameters: knowledge, attitudes towards disaster risks, policies and guidelines, plans for disaster emergencies, disaster warning systems, and the ability to mobilize resources. The data were analyzed descriptively by determining the percentage based on the ready, not ready, and unprepared categories. The research results found that respondents with the ready category were 29 percent, 56 percent less ready, 15 percent not ready. This study concludes that most respondents fall less prepared to face earthquake and tsunami disasters. This result should get the government and other related parties' attention for the safety of the community.Kesiapsiagaan bencana merupakan hal yang penting, terutama untuk masyarakat yang tinggal di daerah rawan bencana. Kota Cilegon memiliki resiko tinggi terhadap bencana gempa bumi dan tsunami. Tujuan penelitian ini adalah mengetahui tingkat kesiapsiagaan masyarakat Kota Cilegon dalam menghadapi bencana gempa bumi dan tsunami. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional. Teknik pengambilan sampel yang digunakan adalah cluster sampling pada Kelurahan sehingga terpilih lima Kelurahan. Seratus responden dari lima Kelurahan diambil secara consecutive. Teknik pengumpulan data dengan menggunakan adopsi kuesioner LIPI-Unesco 2006 yang terdiri dari 38 item pernyataan dari lima parameter, yaitu pengetahuan dan sikap terhadap resiko bencana, kebijakan dan panduan, rencana untuk keadaan darurat bencana, sistem peringatan bencana dan kemampuan untuk memobilisasi sumber daya. Data di analisis secara deskriptif dengan menentukan persentase berdasarkan kategori siap, kurang siap dan tidak siap. Dari hasil penelitian diperoleh bahwa responden dengan kategori siap sebesar 29 persen, kurang siap 56 persen, tidak siap 15 persen. Kesimpulan penelitian ini adalah sebagian besar responden masuk dalam kategori kurang siap dalam menghadapi bencana gempa bumi dan tsunami, hasil ini hendaknya mendapatkan perhatian dari pemerintah dan pihak terkait lainnya demi keselamatan masyarakat.
Assessment of microbiological indoor air quality in a public hospital in the city of Agadir, Morocco
Authors: Oulkheir Said , Safouan Halima , El Housse Fadwa , Aghrouch Mohamed , Ounine Khadija , Douira Allal , Chadli Smail 
Published: July 2022

Background and Purpose: Air is the greatest dissemination agency of pathogenic microbes, which cause significant problem in the indoor hospital environment, in particularly in terms of nosocomial infections. In this context, it is important to know the types of microorganisms present in suspension in an air sample to assess the initial situation and the effectiveness of corrective measures.
Materials and Methods: This study aimed to assessment of microbiological indoor air quality in a three hospital units: central resuscitation, neonatal resuscitation and operating room, using a passive sampling method.
Results: Findings of this study indicated that the central resuscitation recorded the highest bacterial counts population 3.33 102 CFU/m3. Total viable count of fungal was recorded high in neonatal resuscitation. This research showed that Staphylococcus non aureus and Staphylococcus aureus were the most predominant among isolated bacteria. The percentage was 70% -21% in central resuscitation and 79%-13% in operating room. In neonatal resuscitation Staphylococcus non aureus represent (29%) followed by Staphylococcus aureus (19%), Pseudomonas aeruginosa (17%) and Pasteurella pneumotropica (16%). Thus, the fungal genera identified in operating room were Penicillium 61%, Aspergillus niger (20%) and Candida glabrata (19%). In neonatal resuscitation, we found Penicillium 51%, Candida glabrata 25% and Aspergillus niger 20%. In central resuscitation, the most predominant fungi were Cladosporium (30%), Penicillium (28%) and Candida glabrata (13%).
Conclusions: Microorganisms isolated from indoor air constitute microbial reservoirs that may present a risk of infection for both patients and staff. In this light microbiological monitoring of the environment in health facilities is a topic that is part of the news of the prevention of nosocomial infections.
A multi-level system for planning compensatory habitats as a new tool to prevent biodiversity loss in protected areas due to development plans
Authors: Rozman Renata , Tome Davorin , Debeljak Marko 
Published: July 2022

Background
In Slovenia, compensatory habitats (CH) are currently determined on the basis of a subjective expert judgement and without using any clearly defined methodology, due to which the success rates of CH implementation are low. The aim of this research is to fill in a methodological gap and propose a new multi-level system for planning CH. The system assures a transparent and more objective determination of the size of a CH in the processes of appropriate assessments (AA).
Materials and methods:
The system was developed by using a multi criteria decision analysis, a multi-attribute decision support model and the DEXi modelling tool. It was tested on a study case the Škofljica bypass road with its impact to a Whinchat (Saxicola rubetra) at Natura 2000 site Ljubljansko barje.
Results:
The system with three modules and a possibility of what-if analysis was developed to assess the species endangerment and the size of the CH. The system identified that the case study has significant impacts to the Whinchat, therefore the CH of a slightly larger size than the habitat lost was proposed. In addition, the system indicated that only one of the three potential locations of the CH is suitable for implementing the CH.
Conclusions:
The system allows a transparent and more objective assessment of the spatial plan. It is a new, easy-to-use, adjustable, cost- and time-efficient method that can be used to make reliable and transparent decisions during the assessment processes.
Keywords:
Natura 2000; Offsetting; Ecological compensation; Habitat (re)creation; Appropriate Assessment; Sustainable development;
COMFORTABLE ENVIRONMENT AS A FACTOR OF ECONOMIC DEVELOPMENT OF THE TERRITORY
Authors: Кубрак И.А. 
Published: July 2022

Проанализированы результаты реализации городской программы «Формирование комфортной городской среды» в городе Москве, в районе Лефортово Юго-Восточного административного округа. Устройство городской среды, уровень ее комфорта – ведущие направления деятельности муниципальных хозяйств и одни из решающих факторов развития экономики территории. Именно в этой сфере деятельности важно создавать условия, которые будут обеспечивать желаемый уровень комфорта проживания населения и развитие экономической сферы. Рассмотрены примеры повышения экономической активности на территории муниципального района Лефортово в связи с созданием условий для развития предпринимательства.
Th e results of the implementation of the urban program “Comfortable urban Environment” in the city of Moscow, in the Lefortovo district of the South-Eastern Administrative District are analyzed. Th e structure of the urban environment, the level of its comfort are the leading areas of activity of municipal farms and one of the decisive factors in the development of the territory’s economy. It is in this fi eld of activity that it is important to create conditions that will ensure the desired level of comfort for the population and the development of the economic sphere. Examples of increasing economic activity in the territory of the municipal district of Lefortovo in connection with the creation of conditions for the development of entrepreneurial activity are considered.
ANALYSIS OF THE RUSSIAN FEDERA TION FEDERA L DISTRICTS SOCIAL SPHERE
Authors: Третьякова Л.А. , Лисова Е.В. 
Published: July 2022

Анализируются основные подходы к оценке уровня регионального социальноэкономического и социального развития. Описаны недостатки современных методик, выделяется тенденция доминирования социального компонента. Для социальной сферы федеральных округов РФ предложен алгоритм нахождения интегрального показателя ее уровня развития. Предлагается выделить составляющие социальной сферы: «Социальная среда»; «Уровень жизни»; «Жилищные условия»; «Медицина, образование и наука»; «Культура, спорт, отдых и туризм» – и связать их с уровнем социального развития округов РФ. Описана методика определения интегральных показателей по каждой из составляющих, подсчитаны числовые значения для всех российских федеральных округов. Проведен компаративный анализ, сделаны выводы относительно возможности использования предлагаемой методики в других условиях. Описаны основные тенденции, отражающие полученные результаты.
Th e main approaches to assessing the level of regional socio-economic and social development are analyzed. Th e disadvantages of the methods proposed for today are described, the tendency of the dominance of the social component is highlighted. For the social sphere of the federal districts of the Russian Federation, an algorithm for fi nding an integral indicator of its level of development is proposed. It is proposed to identify the components of the social sphere: “Social environment”; “Standard of living”; “Housing conditions”; “Medicine, education and science”; “Culture, sports, recreation and tourism” and link them with the level of social development of the districts of the Russian Federation. Th e method of determining integral indicators for each of the components is described, numerical values for all Russian federal districts are calculated. A comparative analysis was carried out, conclusions were drawn regarding the possibility of using the proposed technique in other conditions. Th e authors describe the main trends refl ecting the results obtained.
ON THE QUESTION OF THE IMPLEMENTATION OF A PRA CTICE - ORIENTED APPROACH IN MODERN LEGAL EDUCATION
Authors: Сливин Т.С. , Тыртышный А.А. , Прядкин В.В. 
Published: July 2022

Рассмотрены некоторые вопросы реализации практико-ориентированного подхода в юридическом образовании. Исследованы модели построения технологий образовательного процесса. Проведен историко-сравнительный анализ реализации различных моделей подготовки юристов. Выявлены критические положения в реализации компентностного подхода в подготовке юристов. Обоснована необходимость гармонизации моделей практико-ориентированного подхода в условиях современных кризисных явлений в юриспруденции.
Th e article discusses some issues of the implementation of a practice-oriented approach in legal education. Th e models of building technologies of the educational process are investigated. A historical and comparative analysis of the implementation of various models of training lawyers was carried out. Th e critical positions in the implementation of the competence approach in the training of lawyers are revealed. Th e necessity of harmonization of practice–oriented approach models in the conditions of modern crisis phenomena in jurisprudence is substantiated.