bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualités nutritionnelle, organoleptique et disposition à payer pour les alternatives à la viande : cas des analogues végétaux, de la « viande in vitro » et des insectes
Authors: BOURDREZ Valentine , CHRIKI Sghaier 
Published: December 2022

Développer les alternatives à la viande est présenté comme une solution pour renforcer la durabilité de l’alimentation tout en apportant des sources de nutriments indispensables (protéines, micronutriments…), notamment pour des régimes végétariens, végans voire flexitariens. Cela peut aussi permettre une diversification du marché de l’agroalimentaire par une plus grande offre de produits aux consommateurs. Mais d’un point de vue nutritionnel, la digestibilité de certains nutriments reste mal connue, et les process pour reproduire les mêmes qualités organoleptiques que la viande sont en cours de développement. Par ailleurs, d’un point de vue économique, le consentement à payer par le consommateur dépend de plusieurs facteurs. Cet article fait le point sur les travaux menés au niveau mondial, entre 1997 et 2021, portant sur trois alternatives, les analogues végétaux, la « viande in vitro » et les insectes. Les indicateurs suivants sont décrits : i) la qualité nutritionnelle (teneur en protéines et leur digestibilité, quantité de graisses et proportion d’acides insaturés, quantité et biodisponibilité du fer et de la vitamine B12), ii) les qualités organoleptiques, et iii) la disposition à payer. Pour les analogues végétaux, une amélioration de de la qualité nutritionnelle (notamment en fer héminique et vitamine B12) et sensorielle est nécessaire pour séduire une partie de la population fortement attachée à la viande, ainsi que les consommateurs atteints de néophobie alimentaire et/ou technologique. Pour la « viande in vitro », en plus de l’amélioration de sa qualité nutritionnelle, son prix est encore inaccessible au grand public. Enfin, l’incorporation des insectes en tant qu’ingrédients semble plus intéressante pour les consommateurs occidentaux, moins habitués à la consommation des insectes entiers.
KONTESTASI OTORITAS AGAMA (STUDI KASUS : FENOMENA WAR DI FACEBOOK DAN INSTAGRAM DAN IMPLIKASINYA TERHADAP INTERNAL UMAT ISLAM)
Authors: Randani Yulia Nafa Fitri , Jalimah Zulfah Latuconsina  , Mukhsin Achmad  
Published: December 2022

Perubahan zaman menjadikan sosial media layaknya kehidupan kedua umat manusia yang mempermudah aktivitas manusia dalam mengakses informasi dan menyampaikan aspirasi maupun keluh kesahnya secara bebas. Kebebasan dalam interaksi di sosial media ini memberikan comfort lebih dibandingkan interaksi di ruang luring khususnya dalam menyampaikan pendapat. Seringkali perbedaan pendapat tokoh berpengaruh dalam Islam atau ulama yang seharusnya menjadi hal yang wajar dalam menanggapi suatu masalah, berujung dengan adu argumen di antara para pengikut atau pengguna sosial media, sehingga war di sosial media menjadi peristiwa daring yang tidak terelakkan. Penelitian studi kasus ini bertujuan untuk mengungkap kontestasi otoritas keagamaan di kalangan pengguna sosial media yang berdampak pada krisis etika dalam interaksi daring dengan maraknya war antar pengguna media sosial dikarenakan perbedaan pendapat dari tokoh yang diikutinya. Adapun metode penelitian yang digunakan dalam penelitian ini berupa deskriptif kualitatif dan dokumentasi data yang di peroleh melalui media sosial dan melakukan pengkajian terhadap data sekunder berupa literatur-literatur ilmiah yang mendukung topik yang diangkat dan wawancara kemudian dianalisis menggunakan teori segitiga konflik Johan Galtung.
A Case Study Quantifying the Influence of Parent Wells on Children Wells in the Northern Midland Basin
Authors: Salts Gregory F. , Fernandes Roland A. , Li Huina , Alonzo Christopher J. 
Published: December 2022

Abstract
The phenomenon of child wells’ Estimated Ultimate Recovery (EUR) underperformance relative to that of parent wells has been well documented in industry papers and investor presentations for several years. The exact mechanisms for the differential performance between parent and child wells are difficult to resolve due to the large number of variables involved. In this case study, we share an engineering analysis on a large and consistent data set and summarize key drivers and learnings from the parent-child relationship.
A fit-for-purpose parent-child classification system was developed to consistently characterize wells as parents or children based on their spatial and development timing characteristics. A geospatial algorithm was then implemented to calculate depletion volumes around child wells prior to the start of the child well production. The results were then analyzed using a statistical approach to identify the key drivers of well performance.
The analysis yielded learnings on the relationship between cumulative oil production and variables reflecting parent-well impact. Studying this relationship led to identification of optimal timing for infill development based on depletion volumes. Additionally, we observed that long-term production performance can be reasonably inferred based on secondary performance indicators including early time GOR and Initial Pump Intake Pressure.
This case study is based on a uniquely consistent data set with a large well count in a highly developed, contiguous area. These wells were drilled at similar spacing, completed with similar fracture intensities and produced by the same artificial lift methods. Because the data set is consistent, the key drivers to child well performance, including depletion and well spacing are evident and quantifiable. All of these characteristics make for a high-quality statistical analysis and provide key learnings and rules of thumb to apply in developing future wells with the goal of improving well performance and economic results.
Results from a Collaborative Parent/Child Industry Study: Permian Basin
Authors: McClure Mark , Albrecht Magdalene , Bernet Carl , Etcheverry Kenneth , Fuhr Aaron , Gherabati Amin , Molina Claudia , Ponners Christopher , Ratcliff Dave , Rondon Janz , Sinha Rohit , Sung Anthony , Xu Jian 
Published: December 2022

Abstract
This paper summarizes results from a collaborative industry study involving seven operators and ten pad-scale datasets across four different shale plays (Delaware, Midland, Bakken, and Montney). This paper specifically focuses on a subset of the datasets from the Midland and Delaware Basins. The project had three main objectives: (a) compare/contrast observations between datasets and basins, (b) develop general insights into parent/child interactions and techniques for mitigating impact, and (c) provide customized economic optimization recommendations for each individual operator and dataset. Each dataset was a high quality ‘science pad,’ involving a full suite of high-quality diagnostics. For each dataset, the observations were synthesized into lists of ‘key observations’ that describe key properties, such as: (a) fracture length and height, (b) productive/drained length and height, (c) GOR, water cut, and RTA trends, (d) production allocations by layer, (e) parent well response to the frac hits, (f) relative performance of the wells, and (g) perforation efficiency and erosion. Next, using an integrated hydraulic fracturing and reservoir simulator, numerical models were constructed to match the key observations of each dataset. The history matching process involved varying formation properties such as permeability, relative permeability, and fracture toughness. After all the models were calibrated, a set of roughly 120 sensitivity analysis simulations was performed on each model. The results were interrogated to identify trends – similarities and differences between the datasets – and to explain ‘what happened and why.’ Finally, the calibrated models were utilized by an automated economic optimization algorithm to provide recommendations for future operations. The simulations do not reveal a ‘silver bullet’ for avoiding parent/child effects. However, they do identify specific changes that could improve performance. Economic performance can be optimized with customized selection of well spacing, job size, and landing depth, based on each company's objectives and price-deck.
Unmasking the Tissue-Resident Eukaryotic DNA Virome in Humans
Authors: Pyöriä Lari , Pratas Diogo , Toppinen Mari , Hedman Klaus , Sajantila Antti , Perdomo Maria F. 
Published: December 2022

Abstract
Background

Little is known on the landscape of viruses that have taken residence within our cells, nor on the interplay with the host imperative for their persistence. Yet, a lifetime of interactions conceivably have an imprint on our physiology and immune phenotype. Importantly, current metagenomics-insights on the healthy human virome are derived from bodily fluids, which are only a proxy of the true prevalence of human eukaryotic viruses within tissues. Most significantly, the virome’s systemic composition in an individual has thus far remained uncharted.

Results

In this work, we revealed the genetic make-up of the eukaryotic human DNA virome in the body and showed that each organ (colon, liver, lung, heart, brain, kidney, skin, blood, hair) has unique viral compositions. By integration of quantitative (qPCR) and qualitative (hybrid-capture sequencing) analysis, we identified the DNAs of 17 viruses, primarily herpes-,
parvo-, papilloma- and anello-viruses (>80% prevalence), typically persisting in low copies (mean 540 copies/ million cells). The within-sample diversities (a-diversity) were highest in the lung, liver, colon, and kidney. We assembled in total 70 viral genomes (>90% breadth coverage), distinct in each of the individuals, and identified high sequence homology across the organs. Moreover, we detected variations in virome composition and distribution in two individuals with underlying malignant conditions.

Conclusions

Our findings reveal unprecedented prevalences of viral DNAs in human organs. We showed that bodily fluids, although accessible to sampling, fail to deliver a comprehensive view of the numerous intracellular viruses colonizing our tissues. Our data demonstrate how a multi-organ approach is essential for analyzing differing virome compositions in various disease states. This atlas provides a fundamental ground for the studies of correlates to disease, and for the interpretation of next-generation sequencing data in clinical virology. Ultimately, our findings call for investigation of the crosstalk between human DNA viruses, the host, and other microbes, as it predictably has a significant impact on our health.
Virtual family-centered rounds: Adapting inpatient care during COVID-19
Authors: Buba Melanie , Dulude Catherine , O'Donnell Roisin , Rowan-Legg Anne , Sloan Megan , Nelson Matthew , King W. James 
Published: December 2022

Abstract
Background:
Family-centered rounds (FCR) are fundamental to pediatric inpatient care. During the COVID-19 pandemic, we aimed to design and implement a virtual family-centered rounds (vFCR) process that allowed continuation of inpatient rounds while following physical distancing guidelines and preserving personal protective equipment (PPE).
Methods:
A multidisciplinary team developed the vFCR process using a participatory design approach. From April through July 2020, quality improvement methods were used to iteratively evaluate and improve the process. Outcome measures included satisfaction, perceived effectiveness, and perceived usefulness of vFCR. Data were collected via questionnaire distributed to patients, families, staff and medical staff, and analyzed using descriptive statistics and content analysis. Virtual auditors monitored time per patient round and transition time between patients as balancing measures.
Results:
Seventy-four percent (51/69) of health care providers surveyed and 79% (26/33) of patients and families were satisfied or very satisfied with vFCR. Eighty eight percent (61/69) of health care providers and 88% (29/33) of patients and families felt vFCR were useful. Audits revealed an average vFCR duration of 8.4 min (SD=3.9) for a single patient round and transition time between patients averaged 2.9 min (SD=2.6).
Conclusion:
Virtual family-centered rounds are an acceptable alternative to in-person FCR in a pandemic scenario, yielding high levels of stakeholder satisfaction and support. We believe vFCR are a useful method to support inpatient rounds, physical distancing, and preservation of PPE that may also be valuable beyond the pandemic. A rigorous process evaluation of vFCR is underway.
Psychosocial functioning in individuals with advanced oesophago-gastric cancer: a mixed methods systematic review
Authors: Ghiglieri Cara , Dempster Martin , Wright Sam , Graham-Wisener Lisa 
Published: December 2022

Abstract
Background
Oesophago-gastric cancer is an aggressive disease with a high rate of recurrence and mortality across the disease trajectory. Reduced psychosocial functioning has been evidenced amongst those with advanced disease, however little is known about the contributing factors. Determining these factors is an important clinical consideration to inform assessment and intervention. This review aimed to synthesize the available evidence on the psychosocial functioning of individuals with advanced oesophago-gastric cancer and their carers.
Methods
A JBI mixed-methods systematic review. Four bibliographic databases, MEDLINE, Embase, PsycINFO, and CINAHL, were searched. Quantitative and qualitative studies were screened for inclusion and critically appraised for methodological quality. Both types of data were extracted using JBI tools for mixed-methods systematic reviews. A convergent segregated approach to synthesis and integration was used. The findings of the synthesis have been configured according to JBI methodology.
Results
A total of 12 studies were included in this review, including 6 quantitative studies and 6 qualitative studies. The quantitative results provide preliminary indication of several physical, biological, psychological and macro-level contextual factors associated with psychosocial functioning in this clinical population. The qualitative findings shed light on a range of physical, psychosocial, and existential challenges faced by advanced oesophago-gastric cancer patients. These multiple and often persistent challenges appear to cause considerable distress; however, patients describe the importance of maintaining a sense of normality and control over their illness and its effects. Patients value continuity and structure, however many report shortcomings when accessing care. No findings reporting the experiences from the perspective of carers were found, therefore all findings represent the perspective of the patient.
Conclusions
Further high-quality research is needed to understand how best to support and manage the palliative care needs of individuals living with advanced oesophago-gastric cancer. Implications for practice are discussed, suggesting that psychosocial interventions, complex symptom management and continuity of care could improve the psychosocial functioning of individuals in this setting.
Pre-registration
The systematic review was pre-registered at the International Prospective Register of Systematic Reviews (PROSPERO; CRD42020181273) and the protocol can be viewed on the OSF (http://osf.io/exuzf)
Comparative Effectiveness of a Mindfulness-Based Intervention (M-Body) on Depressive Symptoms: Study Protocol of a Randomized Controlled Trial in a Federally Qualified Health Center (FQHC)
Authors: Burnett-Zeigler Inger , Zhou Elayne , Martinez Jennifer H. , Zumpf Katelyn , Lartey Lynette , Moskowitz Judith T. , Wisner Katherine L. , McDade Thomas , Brown C. Hendricks , Gollan Jacqueline , Ciolino Jody D. , Schauer Jacob M. , Petito Lucia C. 
Published: December 2022

Abstract
Background.
Mindfulness-based interventions have been shown to improve psychological outcomes including stress, anxiety and depression in general population studies. However, effectiveness has not been sufficiently examined in racially and ethnically diverse community based settings. We will evaluate the effectiveness and implementation of a mindfulness-based intervention on depressive symptoms among predominantly Black women at a Federally Qualified Health Center in a metropolitan city.
Methods.
In this 2-armed, stratified, individually-randomized group-treated controlled trial, 274 English-speaking participants with depressive symptoms ages 18–65 years old will be randomly assigned to (1) eight weekly, 90-minute group sessions of a mindfulness-based intervention (M-Body), or (2) enhanced usual care. Exclusion criteria include suicidal ideation in 30 days prior to enrollment and regular (> 4x/week) meditation practice. Study metrics will be assessed at baseline, and 2, 4, and 6 months after baseline, through clinical interviews, self-report surveys, and stress biomarker data including blood pressure, heart rate, and stress related biomarkers. The primary study outcome is depressive symptom score after 6 months.
Discussion.
If M-Body is found to be an effective intervention for adults with depressive symptoms, this accessible, scalable treatment will widely increase access to mental health treatment in underserved, racial/ethnic minority communities.
Trial Registration.
ClinicalTrials.gov, NCT03620721. Registered on 8, August, 2018.
Bamboo rice: the potential for natural iron and zinc biofortification
Authors: Shao Ji Feng , Hu Qifang , Wang Rong , Hu Lin , Chen Rong , Yu Xuejun 
Published: December 2022

Abstract
Moso bamboo has been shown to accumulate high concentrations of iron and zinc in the seeds. However, the bioavailablity of iron and zinc in bamboo seeds is poorly understood. Here, we evaluated the bioaccessibility and bioavailability of iron and zinc in bamboo seeds using an in vitro digestion protocol. The bioaccessibility and bioavailability of iron in bamboo seeds were 1.6- and 1.7-fold higher than in rice, respectively, and the bioaccessibility and bioavailability of zinc in bamboo seeds were 1.9- and 2.6-fold higher than in rice, respectively. Boiling process reduced both the bioaccessibility and bioavailability of iron and zinc. In addition, bamboo seeds contained lower levels of phytic acid but higher levels of tannins. Iron and zinc were mainly concentrated in the embryo and the aleurone layer. These results suggested that Moso bamboo seeds are rich in iron and zinc and have potential as a food for iron and zinc biofortification.
Risk factors associated with acute kidney injury in a cohort of hospitalized patients with COVID-19
Authors: Contreras Kateir , Barbosa Oscar , Muñoz Ana Cecilia , Suárez Juan Sebastián , González Camilo A , Vargas Diana Carolina , Rodríguez Patricia , García Paola , Valderrama Carolina , Cortés Jorge Alberto 
Published: December 2022

Abstract
Background: Patients with COVID-19 have a high incidence of acute kidney injury (AKI), which is associated with mortality. The objective of the study was to determine the factors associated with AKI in patients with COVID-19.
Methodology: A retrospective cohort was established in two university hospitals in Bogotá, Colombia. Adults hospitalized for more than 48 hours from March 6, 2020, to March 31, 2021, with confirmed COVID-19 were included. The main outcome was the incidence of AKI during the 28 days following hospital admission.
Results: A total of 1584 patients were included: 60.4% were men, 738 (46.5%) developed AKI, 23.6% were classified as KDIGO 3, and 11.1% had renal replacement therapy. The risk factors for developing AKI during hospitalization were male sex (OR 2.27, 95% CI 1.73-2.99), age older than 65 years (1.02, 1.01-1.03), HTN (OR 6.16, 1.98-19.2), the use of vancomycin (1.59, 1.06-2.39), piperacillin/tazobactam (OR 1.65, 1.19-2.28), and vasopressor support (2.36, 1.51-3.69). The gross hospital mortality for AKI was 45.5% versus 11.7% without AKI.
Conclusions: This cohort showed that male sex, age, history of hypertension and chronic kidney disease (CKD), presentation with elevated qSOFA, in-hospital use of nephrotoxic drugs and the requirement for vasopressor support were the main risk factors for developing AKI in patients hospitalized for COVID-19.
Targeted DNA demethylation of the ZNF334 promoter inhibits colorectal cancer growth
Authors: Yang Bin , Tang Haiyu , Wang Nan , Gu Jian , Wang Qin 
Published: December 2022

Abstract
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Aberrant regulation of DNA methylation in promoters of tumor suppressor genes or proto-oncogenes is one of the fundamental processes driving the initiation and progression of CRC. Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and function in many important biological processes related to tumorigenesis. Herein, we detected abnormal hypermethylation of the ZNF334 gene in CRC tissues compared with normal tissues, and this modification downregulated the expression of ZNF334. Furthermore, ten-eleven translocation 1 (TET1) was identified to be involved in regulating the methylation level of ZNF334. Next, a dCas9-multiGCN4/scFv-TET1CD-sgZNF334-targeted demethylation system was constructed to reverse the expression of ZNF334 through sgRNA targeting the ZNF334 promoter. Both in vitro and in vivo experiments demonstrated the targeted demethylation system upregulated ZNF334 expression and inhibited CRC growth. Collectively, targeted DNA demethylation of the ZNF334 promoter sheds light on the precise treatment of CRC.
Bayesian Spatial Modeling of Childhood Overweight and Obesity Prevalence in Costa Rica
Authors: Gómez Mario J. , Barboza Luis A. , Vásquez Paola , Moraga Paula 
Published: December 2022

Abstract
Background: Childhood overweight and obesity levels are rising and becoming a concern globally. In Costa Rica, the prevalence of these conditions has reached alarming levels. Spatial analyses showing geographical patterns and risk factors are required to develop tailored and effective public health actions.
Methods: A Bayesian spatial mixed model was built to understand the geographic patterns of childhood overweight and obesity prevalence in Costa Rica and their association with some socioeconomic factors. Data was obtained from the 2016 Weight and Size Census (school age children) and 2011 National Census.
Results: Average years of schooling increase the levels of overweight and obesity until reaching an approximate value of 8, then, they start to decrease. Besides, for every 10-point increment in the percentage of homes with difficulties to cover their basic needs and in the percentage of population under 14 years old, there is a decrease of 8 and 15 points, respectively, in the odds of obesity.Spatial patterns show higher values of prevalence in the center area of the country, touristic destinations, head of province districts and in the borders with Panama.
Conclutions: Especially for childhood obesity, the average years of schooling is a non-linear factor, describing a Kuznets curve phenomenon. Lower percentages of households in poverty and population under 14 years old are slightly associated with higher levels of obesity. Districts with high commercial and touristic activity present higher risk of prevalence.