bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two efficient block preconditioners for the mass-conserved Ohta-Kawasaki equation
Authors: Zhang Juan , Li shifeng , Jiang Kai 
Published: August 2022

Abstract
In this paper, we propose two efficient block preconditioners to solve the mass-conserved Ohta-Kawasaki equation with finite element dis-cretization. We also study the spectral distribution of these two pre-conditioners, i.e., Schur complement preconditioner and the modified Hermitian and skew-Hermitian splitting (MHSS in short) preconditioner. Besides, the Newton method and its variant are used to address the implicitly nonlinear term. We rigorously analyze the convergence of the Newton iteration methods. Finally, we offer numerical examples to support the theoretical analysis and indicate the efficiency of the proposed preconditioners for the mass-conserved Ohta-Kawasaki equation.
Effects of Dandelion root infusion on heart function and oxidative status of rats
Authors: Radoman Kristina , Zivkovic Vladimir , Zdravkovic Nebojsa , Chichkova Natalia Vasilievna , Bolevich Sergey , Jakovljevic Vladimir 
Published: August 2022

Abstract
This study aimed to examine the effects of dandelion root infusion on rats' heart function and oxidative status. At the beginning of the experimental protocol Wistar albino rats were randomly classified into two groups (10 rats per group):1. control group – animals who drank tap water; 2. experimental group – animals who drank dandelion root infusion for four weeks. Every morning for four weeks, the animals received a fresh infusion of dandelion in a volume of 250 ml. At the end of the experimental protocol, animals were sacrificed and the hearts were isolated and retrogradely perfused according to the Langendorff technique at a gradually increasing perfusion pressure between 40–120 cm H2O. following parameters of myocardial function: maximum rate of pressure development in the left ventricle (dp/dt max), minimum rate of pressure development in the left ventricle (dp/dt min), systolic left ventricular pressure (SLVP), diastolic left ventricular pressure (DLVP), heart rate (HR). The coronary flow (CF) was measured flowmetrically. Blood samples were collected after sacrificing for determination of oxidative stress biomarkers: nitrite (NO2−), superoxide anion radical (O2−), hydrogen peroxide (H2O2), the index of lipid peroxidation (TBARS), reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD). Present results indicated that applied dandelion root infusion did not manifest negative impact on all aspects of heart function and perfusion, pointing him out as a safe cardiac supplement. In addition, dandelion consumption was associated with promising results in terms of maintaining the redox balance which proved it`s antioxidant potential.
Investigation on the Anticancer Activity of [6]-Gingerol of Zingiber Officinale and its Structural Analogs Against Skin Cancer Using Molecular Docking
Authors: A Praveena , A Monisha , B Monisha Baby 
Published: August 2022

Abstract
Skin cancer is the most common type of cancer caused by uncontrolled growth of abnormal cells in the epidermis and the outermost skin layer. This work aimed at determining the anticancer activity of [6]-Gingerol, a bioactive compound from rhizome of Zingiber officinale and its structural analogs against skin cancer. The ethanolic crude extract of the selected plant was subjected to phytochemical and GC-MS analysis to confirm the presence of the [6]-Gingerol. The anticancer activity of extract was evaluated by MTT (3-[4, 5-dimethylthiazol-2-y]-2, 5-diphenyl tetrazolium bromide) assay using the A431 Human skin Adenocarcinoma cell line. The GC-MS analysis confirmed the presence of [6]-Gingerol compound and its promising cytotoxicity IC50 was found at 81.46 ug/ml in the MTT assay. Further, the in silico studies used [6]-Gingerol and 21 structural analogs collected from PUBCHEM database to investigate the anticancer potential and drug likeliness property. Skin cancer protein, DDX3X was selected as target which regulates all stages of RNA metabolism. It was docked with 22 compounds which includes [6]-Gingerol and 21 structural analogs, the potent lead molecule was selected based on lowest binding energy value. Thus the [6]-Gingerol and its structure analogs could be used as lead molecule against skin cancer and future drug development process.
Genetic population structure of mud crab (Scylla olivacea) in the Bay of Bengal inferred from mitochondrial DNA and microsatellite markers
Authors: Sarower Mohammed Golam , Hasan Md Mehedi , Okada Shigeru 
Published: August 2022

Abstract
The increasing exploitation of Scylla olivacea, one of the most commercially consumed mud crabs inhabiting mangroves and estuaries of the Bay of Bengal has been seriously experiencing a constant decline of its population. Information on its genetic population structure is crucial for the conservation of S. olivacea. Here, partial sequences of the mitochondrial cytochrome c oxidase subunit I (COI) gene and ten microsatellite loci were used to estimate population genetics from four localities in the Bay of Bangladesh. Genotypes of mitochondrial DNA (mtDNA) were identified with an 848 bp fragment sequence of COI gene, defining 32 different haplotypes from H1 to H32. H4 was the most frequently observed haplotype, existing in all four localities, while the majority of haplotypes were rare ones, existing in only one individual. Neutrality tests and mismatch analysis conferred a potential population expansion event for this crab species. Diploid genotypes were determined with microsatellite loci, delineating several alleles at each locus, significant linkage disequilibrium and deviation from Hardy-Weinberg equilibrium. The AMOVA analysis of mtDNA suggested a low level of genetic differentiation among four localities (FST = 0.0172, P > 0.05) while microsatellite markers showed a moderate genetic differentiation (FST = 0.0687, P > 0.05). The lower level of differentiation of mtDNA than microsatellites possibly resulted from female-mediated gene flow between populations, biased sex ratios, natural selection, or mutation.
Fermentation conditions of lactobacilli for the production of lactose-free starter culture
Authors: Imanbayeva Madina , Masalimov Zhaksylyk , Sagyndykov Utemurat 
Published: August 2022

Abstract

A total of 16 strains of Lactobacilli were isolated from traditional Kazakh homemade dairy products. The strains identified by 16sRNA sequencing. The aim of this study was to evaluate probiotic properties of Lactic acid bacteria (LAB) Lactobacillus acidophilus (Lb. acidophilus) and Lactobacillus rhamnosus (Lb. rhamnosus) cultures were chosen as starter probiotic strains. Tested strains were had strong inhibitory effect against Gram-negative pathogens: Salmonella typhimurium (S. typhimurium), Serratia marcescens (S. marcescens) and Escherichia coli (E. coli). We evaluated the tolerance to various pH values (3.0, 4.0, 5.0, 6.4, 8.5), survivability in different salt concentrations (2%, 5%, 7%). All isolates survived at pH 3.0–4.0, 5–7% NaCl. The pasteurized milk (PM) was inoculated with two starters lactic acid bacteria performed for 24 h at 37°C. Lb. acidophilus and Lb. rhamnosus starter culture reached cell population of about ~ 8 logs colony forming unit (CFU/mL) during co-culture fermentation, pH in pasteurized milk rapidly decreased to 3.0.
Coronary Flow Velocity Reserve is Decreased in Patients with Restless Leg Syndrome
Authors: Güz Göksel , Demirgan Serdar 
Published: August 2022

Abstract
IntroductionIn this study, we aimed to evaluate coronary endothelial dysfunction in restless legs syndrome(RLS) patients using coronary flow velocity reserve(CFVR) and compared it with healthy controls.MethodIn this study, the participants were divided into two groups as group RLS(n=42) and group HC(n=41). The primary outcome was the CFVR compared between groups. The number of participants with a CFVR value below 2.0 was also evaluated. In addition, a correlation between the international restless legs scale(IRLS) and CFVR, white-blood-cell-count(WBC), C-reactive-protein(CRP) were analyzed. Secondary outcomes were the WBC, hemoglobin, CRP, blood glucose, high-density-lipoprotein(HDL), low-density-lipoprotein(LDL), and creatinine compared between the two groups.ResultsA total of 116 participants were recruited for this study, and 83 participants(42 in Group RLS and 41 in Group HC) were ultimately enrolled. In the group RLS, CFVR was measured lower than healthy controls(p<0.001). When the groups were compared in terms of the number of participants with a CFVR less than 2.0, the difference between the groups was significant(p<0.001, 0/41 in group HC and 14/42 in group RLS).Patients with RLS had higher WBC and CRP values. There was a negative correlation between CFVR and IRLS(p<0.001). The relationship between WBC, CRP, and IRLS was not statistically significant(p=0.691).Discussion/ConclusionWe conclude that RLS patients had lower CFVR compared with healthy controls and there was a negative correlation between the severity of RLS and CFVR which indicates coronary endothelial function. Therefore, we think that it may be beneficial to follow up patients with RLS in terms of coronary heart disease.
Gender and labor supply in Cameroon: an analysis in terms of job satisfaction
Authors: Meka'a Cosmas Bernard , Fotso Silvain Raoul 
Published: August 2022

Abstract
The main objective of this article is to analyze, according to gender, job satisfaction in the labor market in Cameroon. To do this, we use data from the fourth Cameroon Household Survey (ECAM4) carried out in 2014 by the National Institute of Statistics. To estimate the determinants of job satisfaction, we use the estimation of a simple logit model.The results of the logit model regressions and robustness tests show that for the same income, the probability of a man being satisfied at work is less than that of a woman. Moreover, the estimate of the marginal effects shows overall that it is more likely for a woman who works part-time to be satisfied with her job than for a woman who works full-time or for a man.JEL Classification: J16-J28-C25-C13
A predictive scoring system for small diaphragmatic defects in infants with congenital diaphragmatic hernia
Authors: Terui Keita , Nagata kouji , Yamoto Masaya , Hayakawa Masahiro , Okuyama Hiroomi , Amari Shoichiro , Yokoi Akiko , Furukawa Taizo , Masumoto Kouji , Okazaki Tadaharu , Inamura Noboru , Toyoshima Katsuaki , Koike Yuki , Okawada Manabu , Sato Yasunori , Usui Noriaki 
Published: August 2022

Abstract
Purpose: To develop a predictive score for small diaphragmatic defects in infants with congenital diaphragmatic hernia (CDH).Methods: The Japanese CDH Study Group cohort was randomly divided into derivation (n = 397) and validation (n = 396) datasets. Using logistic regression, a prediction model and weighted scoring system for small diaphragmatic defects were created from derivation dataset and validated with validation dataset.Results: Six weighted variables were selected: no hydramnios, 1 point; 1-minute Apgar score of 5–10, 1 point; apex type of the lung (left lung is detected radiographically in apex area), 1 point; oxygenation index < 8, 1 point; abdominal nasogastric tube (tip of the nasogastric tube is detected radiographically in abdominal area), 2 points; no right-to-left flow of ductus arteriosus, 1 point. In validation dataset, rates of small diaphragmatic defects for Possible (0–3 points), Probable (4–5 points), and Definite (6–7 points) groups were 36%, 81%, and 94%, respectively (p < 0.001). Additionally, sensitivity, specificity, positive predictive value, and C statistics were 0.78, 0.79, 0.88, 0.76, and 0.45, 0.94, 0.94, 0.70 for Probable and Definite groups, respectively.Conclusion: Our simple scoring system effectively predicted small diaphragmatic defects in infants with CDH and is useful to determine thoracoscopic surgery indication.
Optimization of Hydrolysis in Ethanol Production from Sugarcane Bagasse
Authors: WORKU NIGUS 
Published: August 2022

Abstract
This research involved optimizing acid hydrolysis in the development of ethanol, a promising alternative energy source for restricted crude oil, from lignocellulosic materials (Sugarcane Bagasse). The conversion of Sugarcane Bagasse to ethanol can mainly be accomplished through three process steps: pretreatment of Sugarcane Bagasse for the removal of lignin and hemicellulose, acid hydrolysis of pretreated Sugarcane Bagasse for the conversion of cellulose into sugar reduction (glucose) and fermentation of sugars into ethanol using anaerobic Saccharomyces cerevisiae. The effects of parameters (factors) in the hydrolysis step were investigated and the optimum combination of parameters values (temperature, time, and acid concentration) was set by experimentation. A factorial design of three-factors-at-two-level with a replica of two (23 = 8, 8*2 = 16) was applied to the hydrolysis step to investigate the effect of hydrolysis parameters on the response variable (ethanol yield) using Design-Expert® 13 software.
Efficacy and safety of ultrasound-guided percutaneous laser ablation in the treatment of unifocal papillary thyroid microcarcinoma
Authors: Zhou Feng , Yu Zepeng , Sun Xingwei , Wu Qin , Zheng Kun , Qiao Shigang , Fan Xing , Gu Jun 
Published: August 2022

Abstract
AbstractObjective Ultrasound-guided percutaneous laser ablation (US-PLA), as a minimally invasive ablation method, has been widely used in the treatment of benign and malignant tumors. The objective of the current study is to determine the efficacy and safety of US-PLA for unifocal papillary thyroid microcarcinoma (PTMC).Methods 18 patients with pathologically confirmed PTMC underwent US-PLA at our institution. Tumor location, tumor volume and thyroid function were evaluated before PLA. Contrast-enhanced ultrasound (CEUS) was performed immediately after PLA treatment. Complications, thyroid function, ablation area size and volume, tumor recurrence rate and metastasis rate were recorded. The ablation zone size was also compared with the original tumor size before ablation at each follow-up time point.Results 18 nodules were completely ablated in 18 patients, and postoperative CEUS showed no contrast fill in the ablated areas. 15 patients underwent single needle and single PLA ablation, and 3 cases underwent a second ablation due to incomplete ablation as confirmed by CEUS. All patients tolerated and completed ablation. No serious complications occurred. The maximum diameter and volume of the ablation zone at 6, 12, 18, and 24 months after PLA were significantly smaller than the preoperative nodules. The number of tumors that completely disappeared at 6, 12, 18, and 24 months was 1 (5.56%), 6 (38.89%), 4 (61.11%), and 2 (72.22%), respectively. No local tumor recurrence, lymph node metastasis and distant metastasis occurred.Conclusion US-PLA is a safe and effective treatment that may provide a new treatment option for patients with PTMC.
Efficient Thermal Comfort Estimation Employing the C-Mantec Constructive Neural Network Model
Authors: Ortega-Zamorano Francisco , Jerez José M , Rodríguez-Alabarce José , Goreishi Kusha , Franco Leonardo 
Published: August 2022

Abstract
Thermal comfort is the condition in which a person feels satisfaction with the thermal environment through a subjective evaluation. In this work, a compact and efficient estimation of thermal comfort perception by human subjects is performed using a constructive neurocomputational model trained with data generated in controlled conditions with 49 volunteers giving 705 different scenarios, allowing, thanks to the versatility of the model, an interpretable and simple resulting function facilitating an easy handling of the results by people from different fields. The results have been compared with two of the most used standard methods for modelling thermal comfort: Fanger and COMFA models, and they show an improvement in terms of accuracy and mean square error both in a binary decision scenario (comfort or not) as well as for a discrete decision-making case in which different thermal comfort regions are considered. The flexibility of the neural model permits the incorporation of extra subject-related variables that increases further the thermal comfort estimation and, also, permits the implementation of the model in distributed and low cost/low consumption systems.
An evolutionary framework for server placement optimization of large-scale online media services system
Authors: Chen Shaomiao , Li Zhiyong 
Published: August 2022

Abstract
Server placement optimization is one of the important contents of online media services system construction. How the system spends the least deployment cost to provide users with sufficient bandwidth is the optimization goal of the server placement problem. The problem is a NP-hard combinatorial optimization problem. Evolutionary algorithms show outstanding global optimization capabilities in this type of optimization problem compared to constructive heuristic method. However, the high dimensionality of the problem and the complicated evaluation of the deployment plan make the evolutionary algorithm easy to fall into the local optimum, and the computational cost is high. In this research, we propose an evolutionary framework for the server layout optimization, which can greatly improve the optimization efficiency of evolutionary algorithms and reduce the computational cost of the algorithm. In the framework, an offline-learning based approach is used to reduce the search space and a self-examining guided local search method is proposed to improve the search efficiency. Moreover, a look-up table based hybrid approach use to solution evaluation which can reduce computational overhead. Experiment results show that the proposed framework and optimization strategy can greatly improve the evolutionary algorithm search efficiency and has a good convergence performance.
Combining old and new media for Islamic da’wa activity: The Case of Indonesian Nursi movement
Authors: Adeni Adeni , Koroglu Osman , Hasanah Silviatul 
Published: August 2022

Purpose - The purpose of this study was to analyze the combination of old and new media use in Nursi movement da’wah in Indonesia.Method– This study used a qualitative method by an approach of combining old and new media in da’wah. The data were collected by interviewing Indonesian figures, observing the Nursi’s da’wah activities, and reading the Risale-I Nur.Result - The results showed that the Nursi movement emphasized a combination of old and new media in doing da’wah. Old media used the Risale-I Nur as a writing media and the radio as an electronic media. The old one was used for disseminating da’wah messages related to theological (aqidah) and Islam law content suitable to the controlling character of old media. New media such as blog-website, WhatsApp, YouTube, Facebook, and Instagram were used for conveying da’wah in the form of good words, spiritual advice, and avoiding the issues of khilafiyah (Islamic thoughts differences). It is relevant to the democratic character of new media.Implication –This study suggested that the use of old and new media in da’wah should be combined. It is to contribute to disseminating a comprehensive da’wah. Originality – The study was the first work in the da’wah field that emphasizes the urgency of combining old and new media use in da’wah activities.***Tujuan - Tujuan dari penelitian ini adalah untuk menganalisis kombinasi penggunaan media lama dan baru dalam dakwah gerakan Nursi di Indonesia.Metode– Penelitian ini menggunakan metode kualitatif dengan pendekatan menggabungkan media lama dan media baru dalam dakwah. Pengumpulan data dilakukan melalui wawancara dengan tokoh-tokoh Nursi Indonesia, mengamati kegiatan dakwah Nursi, dan membaca Risale-I Nur.Hasil - Hasil penelitian menunjukkan bahwa gerakan Nursi menekankan kombinasi media lama dan media baru dalam berdakwah. Media lama yang digunakan adalah Risale-I Nur sendiri sebagai media tulis dan radio sebagai media elektronik. Media lama digunakan untuk menyebarluaskan pesan-pesan dakwah terkait muatan teologis (aqidah) dan syariat Islam yang sesuai dengan karakter pengendali media lama. Media baru seperti blog-website, WhatsApp, YouTube, Facebook, dan Instagram digunakan untuk menyampaikan dakwah dalam bentuk kata-kata yang baik, nasihat spiritual, dan menghindari isu-isu khilafiyah (perbedaan pemikiran Islam). Hal ini relevan dengan karakter demokratis media baru.Implikasi – Penelitian ini menyarankan agar penggunaan media lama dan baru dalam dakwah harus dikombinasikan. Hal ini untuk berkontribusi dalam menyebarluaskan dakwah yang komprehensif.Orisinalitas – Kajian ini merupakan karya pertama dalam bidang dakwah yang menekankan urgensi menggabungkan penggunaan media lama dan baru dalam kegiatan dakwah.
Quantity–quality-based water allocation programming in a reservoir–river system
Authors: Ebrahimi Abbas , Shourian Mojtaba 
Published: August 2022

Abstract
Simulation–optimization approaches are useful methods for the assessment of water resource engineering plans and finding the best management policy at the watershed scale. In this study, to find the optimum operation for a reservoir with the purpose of satisfying water demands while meeting the water quantity and quality criteria, a generic reservoir and river basin simulation model (MODSIM) is coupled with the particle swarm optimization (PSO) algorithm leading to construct the PSO–MODSIM model. With the decision variables of the reservoir's monthly releases, the objective function is to maximize the supply for downstream demands while keeping the electrical conductivity (EC) in the river flow lower than a predefined level at the downstream checkpoint, which is a function of the EC in the agricultural return flows. Moreover, a safe flow rate is defined in which the streamflow should not exceed at the checkpoint resulting in mitigation of the submerging lands damage. Results obtained by the PSO–MODSIM model indicate the ability of the proposed simulation–optimization approach for solving the problem of optimal quantity–quality-based water allocation in a reservoir–river system. For instance, the EC at the checkpoint is decreased by 61% in the optimum reservoir operation state comparing the present situation, whereas the municipal and environmental demands are fully met and the agricultural demands are supplied with a desirable reliability satisfaction level.
A Comprehensive Description of Hypoxia-inducible Factor 2α Inhibitors
as Anticancer Agents: A Mini-review
Authors: Lu Hongyuan , Zhu Yan , Liu Wenwu , Yan Yuanyuan , Jiang Xiaowen , Wang Qinbiao , Zhao Yanyun , He Miao , Wei Minjie 
Published: August 2022

Abstract:
Targeting the tumor microenvironment is a promising strategy to prevent metastasis,
overcome acquired drug resistance, and improve the therapeutic effect. Hypoxia
is one of the characteristics of the tumor microenvironment, which is mainly regulated by
hypoxia-inducible factors. Hypoxia-inducible factors (HIFs) including HIF-1α, HIF-2α,
and HIF-3α, of which HIF-2α has assumed a more important role in tumor hypoxia environment.
It has been demonstrated that HIF-2α plays an important role in tumor diseases,
including renal cell carcinoma, breast cancer, non-small cell lung cancer, and gastric cancer,
among others. Therefore, targeting HIF-2α has become one of the important strategies
for treating cancers. HIF-2α inhibitors can be divided into two categories: specific inhibitors
and non-specific inhibitors. The former includes synthetic monomer compounds
and traditional Chinese medicine extracts. In this review, we summarized, classified, and
discussed current research on the structure, structure-activity relationship (SAR), and
pharmacology of HIF-2α inhibitors, which is helpful to the rational design of effective
drugs for various types of malignant tumors.