bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in ZnO: Manipulation of defects for enhancing their technological potentials
Authors: Ayoub Irfan , Kumar Vijay , Abolhassani Reza , Sehgal Rishabh , Sharma Vishal , Sehgal Rakesh , Swart Hendrik C. , Mishra Yogendra Kumar 
Published: February 2022

Abstract
This review attempts to compile the physics and chemistry of defects in zinc oxide (ZnO), at both, the fundamental and application levels. The defects, either inherent ones or introduced externally, have broadened the ZnO material field in various directions. The ZnO material exhibits many defect-attributed properties leading to broad technological applications: electronic and optoelectronic devices, sensors, optical components, ceramic industry, biomedical, catalysis, lightening, etc. Considering the huge defect-dependent technological scopes, the ZnO material is constantly engineered for various defects, and corresponding functionalities are tailored with respect to particular applications. The functional properties of ZnO are strongly influenced by the defects, and as a result, the defect engineering of the ZnO materials has remained an important motivation in materials science and engineering in terms of localized defects, extended defects, impurities, and surface defects, etc. A detailed characterization of these defects seems to be an essential part of any research area. The correlations of the microstructural characteristics with electrical and optical properties of ZnO are then a natural step for further facilitating an efficient way toward advanced ZnO-based materials and devices. The present review is an effort to shed light on the defects of ZnO, properties, theoretical aspects, and corresponding applications.
Analysis of initiator content of prepreg by near-infrared spectroscopy
Authors: Liu Qianfa , Li Dan , Guan Chiji 
Published: February 2022

Abstract
During the production process of some copper clad laminate (CCL), the content of 3,3,5,7,7-pentamethyl-1,2,4-trioxepane in prepreg can affect the cross-linking and curing degree of resin directly, and thereby affect the properties of CCL. In this article, near-infrared (NIR) spectroscopy combined with partial least square regression using high performance liquid chromatography as a reference method were used for the determination of 3,3,5,7,7-pentamethyl-1,2,4-trioxepane in the CCL production progress. 160 spectra of prepreg samples randomly formed the calibration set, and 50 spectra of prepreg samples formed the validation set. The value of the root mean square error of calibration (w/w) and root mean square error of prediction (w/w) were 0.011% and 0.013% for 3,3,5,7,7-pentamethyl-1,2,4-trioxepane content (%, w/w), and the calculation and validation of the regression equation resulted in high correlation coefficients of 0.99 and 0.98, respectively. The scatter plot value of calibration set which was obtained from the root mean square error of cross-validation (w/w) was 0.015%, and the regression equation resulted in high correlation coefficient of 0.98. The results of the paired t-test revealed that there was no significant difference between NIR and HPLC method. Thus, the results obtained in this study reflect that NIR could be used as a rapid, accurate, and simultaneous technique to determine 3,3,5,7,7-pentamethyl-1,2,4-trioxepane content of prepreg in the production process.
Comparing what the clinician draws on a digital pain map to that of persons who have greater trochanteric pain syndrome
Authors: Plinsinga Melanie L. , Boudreau Shellie A. , Coombes Brooke K. , Mellor Rebecca , Hayes Sandi , Vicenzino Bill 
Published: February 2022

Abstract

Objectives
To assess the agreements and differences in pain drawings (pain area, shape and location) between individuals who have greater trochanteric pain syndrome (GTPS) and their clinician.

Methods
In this study, 23 patients with GTPS (21 female, pain duration range 8–24 months) underwent clinical evaluation by a registered physiotherapist. Digital 2d full body pain drawings were independently performed by the clinician during the subjective examination and by the patient following the physical examination. Levels of agreement [LoA] in the pain area were assessed with Bland–Altman plots. Differences in pain drawings were assessed visually by overlaying images, and by quantifying the differences in shape and location with the bounding box, and Jaccard index, respectively.

Results
Pain areas (/total pixels of the charts) did not differ in size (LoA mean difference less than −0.5%; range −2.35–1.56%) or shape (bounding box p>0.17). However, there was minimal overlap in location (Jaccard index range 0.09–0.18/1 for perfect overlap).

Conclusions
Patients and the clinician displayed differences in location of pain areas, but not size or shape, when they independently performed digital pain drawings. The reasons that underlie and the clinical impact of these differences remains unclear.
Synthesis, structure characterization and properties of a new oxidovanadium(IV) coordination polymer incorporating bridging (MoO4)2– and (Mo8O26)4– ligands
Authors: Harmalkar Nikita N. , Srinivasan Bikshandarkoil R. , Dhuri Sunder N. 
Published: February 2022

Abstract
Hydrothermal synthesis, crystal structure and properties of a new heterometallic coordination polymer [(VO(terpy))4(MoO4)2(Mo8O26)]·2H2O (1) (terpy = 2,2′;6′,2″-terpyridine) are reported. Compound 1 contains two crystallographically unique vanadium(IV) atoms, bonded to a terminal oxido ligand and further coordinated to a terpy ligand. The three N atoms of terpy occupy the meridional sites of a distorted {VN3O3} octahedron. A γ-octamolybdate (Mo8O26)4– located on an inversion centre and a tetraoxidomolybdate (MoO4)2– function as bridging ligands. The μ3-bridging tridentate binding of (MoO4)2– leads to the formation of a {V4Mo2O12}4+ cationic unit consisting of an eight-membered heterometallic {Mo2V2O4} ring with protruding oxidovanadium handles. A pair of {V4Mo2O12}4+ units are bridged by the centrosymmetric (Mo8O26)4– ligand, resulting in the formation of an infinite chain of alternating {V4Mo2O12}4+ cations and (Mo8O26)4– anions.
A Farnesyltransferase Inhibitor Restores Cognitive Deficits inTsc2+/–Mice through Inhibition of Rheb1
Authors: Sugiura Hiroko , Shimada Tadayuki , Moriya-Ito Keiko , Goto Jun-Ichi , Fujiwara Hiroki , Ishii Rie , Shitara Hiroshi , Taya Choji , Fujii Satoshi , Kobayashi Toshiyuki , Hino Okio , Worley Paul F. , Yamagata Kanato 
Published: February 2022

Tuberous sclerosis complex (TSC) is caused by mutations inTsc1orTsc2, whose gene products inhibit the small G-protein Rheb1. Rheb1 activates mTORC1, which may cause refractory epilepsy, intellectual disability, and autism. The mTORC1 inhibitors have been used for TSC patients with intractable epilepsy. However, its effectiveness for cognitive symptoms remains unclear. We found a new signaling pathway for synapse formation through Rheb1 activation, but not mTORC1. Here, we show that treatment with the farnesyltransferase inhibitor lonafarnib increased unfarnesylated (inactive) Rheb1 levels and restored synaptic abnormalities in culturedTsc2+/−neurons, whereas rapamycin did not enhance spine synapse formation. Lonafarnib treatment also restored the plasticity-related Arc (activity-regulated cytoskeleton-associated protein) expression in culturedTsc2+/−neurons. Lonafarnib action was partly dependent on the Rheb1 reduction with syntenin. Oral administration of lonafarnib increased unfarnesylated protein levels without affecting mTORC1 and MAP (mitogen-activated protein (MAP)) kinase signaling, and restored dendritic spine morphology in the hippocampi of maleTsc2+/−mice. In addition, lonafarnib treatment ameliorated contextual memory impairments and restored memory-related Arc expression in maleTsc2+/−micein vivo. HeterozygousRheb1knockout in maleTsc2+/−mice reproduced the results observed with pharmacological treatment. These results suggest that the Rheb1 activation may be responsible for synaptic abnormalities and memory impairments inTsc2+/−mice, and its inhibition by lonafarnib could provide insight into potential treatment options for TSC-associated neuropsychiatric disorders.SIGNIFICANCE STATEMENTTuberous sclerosis complex (TSC) is an autosomal-dominant disease that causes neuropsychiatric symptoms, including intractable epilepsy, intellectual disability (ID) and autism. No pharmacological treatment for ID has been reported so far. To develop a pharmacological treatment for ID, we investigated the mechanism of TSC and found that Rheb1 activation is responsible for synaptic abnormalities in TSC neurons. To inhibit Rheb1 function, we used the farnesyltransferase inhibitor lonafarnib, because farnesylation of Rheb1 is required for its activation. Lonafarnib treatment increased inactive Rheb1 and recovered proper synapse formation and plasticity-related Arc (activity-regulated cytoskeleton-associated protein) expression in TSC neurons. Furthermore,in vivolonafarnib treatment restored contextual memory and Arc induction in TSC mice. Together, Rheb1 inhibition by lonafarnib could provide insight into potential treatments for TSC-associated ID.
Shellac as Musical Plastic
Authors: Williams Gavin 
Published: February 2022

AbstractShellac was essential to the gramophone industry throughout the first half of the twentieth century, yet the material has long kept a low profile. At once inaudible and urgently required, shellac was a plastic and colonial commodity with wide-ranging applications. Building on recent scholarship that explores its ecological imbrication, this article additionally presents a case for understanding it as a musical thing. First, it shows how lac—the resinous encrustation of the lac insect, and a South Asian technique for preserving things over time—became a global commodity, shellac, aiding the development of sound reproduction. Second, it investigates a scientific bureaucracy promoting the study of the lac insect, which emerged in Indian forests during the 1920s. Third, it tracks how musical demand intensified a system of migrant, indentured, and technical labor involved in processing lac into shellac. In reconstructing shellac’s economic and scientific networks, the article argues that the material was a multiplicity, which entailed both the entangled knowledge systems of its production and a decisive switch: from bodily techniques of production into those of mediated musical listening. Through a focus on shellac, it decenters North American narratives about the development of sound reproduction technology, showing how South Asian knowledge, labor, and environments were profoundly involved, even if they were only rarely acknowledged in mediated musical experiences. Indeed, in an age before synthetic hydrocarbon polymers, shellac fulfilled the role of musical plastic through its inconspicuousness: its capacity to hold and harmonize multiple disc ingredients, while disappearing into the background it supplied.
Chinese Ears, Delicate or Dull? Toward a Decolonial Comparativism
Authors: Hu Zhuqing (Lester) S. 
Published: February 2022

Abstract
This article compares extractivist ideologies of voice and listening in late eighteenth-century Europe and China to envision a decolonial comparativism. Inspired by Dylan Robinson’s “apposite methodology,” the article “writes with” the French Jesuit Jean-Joseph-Marie Amiot, who compared European and Chinese ears several times during his career in Beijing to ascertain why the Chinese abhorred European harmony. Through his correspondence with the Republic of Letters, Amiot’s comparisons resonated with the “sharp-eared Chinese” trope in European discourse. The dialectics of this trope, laid bare in Johann Gottfried Herder’s surprisingly similar denigrations of China and of deafness, reflected an extractivist phonocentrism by which recognition of one’s subjectivity required opening oneself up to society’s extractive listening. Hegel and post-Thermidorian French elites even posited such extraction as the foundation for pluralism and progress. Though specifically othered by European phonocentrism, the Qing Empire then ruling China articulated similar ideologies. While Amiot compared the qupai stock melodies of Kunqu theater to the vaudeville songs of opéra-comique, eighteenth-century Qing court adaptations of Kunqu departed from the pervasive use of qupai to achieve a transcendent positionality of listening. Qing-imperial ethnographies of languages and songs further revealed such transcendent listening as undergirding the multiethnic empire, where subjecthood depended on proffering a voice to the imperial ear via an extractive phonography (“voice-writing”). The article concludes by situating this phonocentrism shared between Europe and China within current academic discourses on decolonization and deimperialization. It argues that comparativism can create spaces that facilitate “turning away” from the extraction of voices, which continues to sustain imperial hegemonies as uniquely transcendent ears.
An impressive response with larotrectinib in a patient with a papillary thyroid carcinoma harboring an SQSTM1-NTRK1 fusion
Authors: Bargas Sophie , Mc Leer Anne , Mondet Julie , Chabre Olivier , Laramas Mathieu 
Published: February 2022

NTRK
rearrangements represent a very rare genomic abnormality among all cancers but can be detected in thyroid cancer with a non-negligible frequency of 2%. Dramatic clinical responses to therapies targeting NTRK chimeric proteins are now well described in the literature. SQSTM1-NTRK1fusions have not yet been described in a full clinical case report. We report a patient with a papillary thyroid carcinoma harboring this unique rearrangement, with an impressive clinical and radiologic response to larotrectinib, a highly specific inhibitor.
Effect of obstructive sleep apnea on glucose metabolism
Authors: Koh Han-Chow E , van Vliet Stephan , Cao Chao , Patterson Bruce W , Reeds Dominic N , Laforest Richard , Gropler Robert J , Ju Yo-El S , Mittendorfer Bettina 
Published: February 2022

Background
Obstructive sleep apnea (OSA) is prevalent in people with obesity and is a major risk factor for type 2 diabetes (T2D). The effect of OSA on metabolic function and the precise mechanisms (insulin resistance, β-cell dysfunction, or both) responsible for the increased T2D risk in people with OSA are unknown.

Design and methods
We used a two-stage hyperinsulinemic–euglycemic clamp procedure in conjunction with stable isotopically labeled glucose and palmitate tracer infusions and 18F-fluorodeoxyglucose injection and positron emission tomography to quantify multi-organ insulin action and oral and intravenous tolerance tests to evaluate glucose-stimulated insulin secretion in fifteen people with obesity and OSA and thirteen people with obesity without OSA.

Results
OSA was associated with marked insulin resistance of adipose tissue triglyceride lipolysis and glucose uptake into both skeletal muscles and adipose tissue, whereas there was no significant difference between the OSA and control groups in insulin action on endogenous glucose production, basal insulin secretion, and glucose-stimulated insulin secretion during both intravenous and oral glucose tolerance tests.

Conclusions
These data demonstrate that OSA is a key determinant of insulin sensitivity in people with obesity and underscore the importance of taking OSA status into account when evaluating metabolic function in people with obesity. These findings may also have important clinical implications because disease progression and the risk of diabetes-related complications vary by T2D subtype (i.e. severe insulin resistance vs insulin deficiency). People with OSA may benefit most from the targeted treatment of peripheral insulin resistance and early screening for complications associated with peripheral insulin resistance.
Problematic online gambling among adolescents: A systematic review about prevalence and related measurement issues
Authors: Montiel Irene , Ortega-Barón Jéssica , Basterra-González Arantxa , González-Cabrera Joaquín , Machimbarrena Juan Manuel 
Published: February 2022

Abstract

Background and aims
Despite its illegality among adolescents, online gambling is a common practice, which puts their mental health and well-being at serious risk. This systematic review summarises international scientific literature from the last 20 years on problematic online gambling among adolescents (11–21 years old) to determine its prevalence and to analyse related measurement issues.

Methods
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed and a protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO, IC: CRD42020162932). Five academic databases were consulted, which resulted in an initial sample of 658 papers.

Results
Sixteen studies met the inclusion criteria for this review. All studies were cross-sectional and targeted students from elementary school, secondary school or university. Most followed a convenience sampling procedure. The primary measurement instruments used were the DSM-IV-MR-J and SOGS-RA. Between 0.77% and 57.5% of adolescents present some degree of problematic online gambling (problem, pathological or disordered) depending on the instruments used, the study samples and the timeframe analysed. Between 0.89% and 1% of adolescents exhibited an online gambling disorder.

Discussion and conclusion
There is a great heterogeneity in the methodology of the reviewed studies (samples, measurement instruments, cut-off points and criteria applied). The limited number of studies and the limited generalizability of their results suggest the need for further research and for development of specific instruments to assess different levels of problematic online gambling in representative samples of adolescents based on clinical ‘gold standard’ criteria and more accurate cut-off points.
Relationship between location of epileptic focus and occurrence during sleep versus wakefulness
Authors: Narang Pooja , Garg Divyani , Shukla Garima , Singh Mamta Bhushan , Srivastava Achal , Gupta Anupama , Suri Ashish , Garg Ajay , Bal CS. , Vibha Deepti , Pandit Awadh Kishor , Prasad Kameshwar 
Published: February 2022

AbstractObjective. Different sleep stages exert differential effects on interictal discharges, neural synchrony and seizure threshold. We sought to assess the relationship between localization of the epileptogenic focus and seizure distribution in sleep versus wakefulness among patients with refractory epilepsy.Methods. We conducted a retrospective chart review‐based study. Video‐electroencephalography of patients with refractory epilepsy, planned for resective surgery, were reviewed for seizure localisation and occurrence relative to stage of sleep/wakefulness. Demographic/clinical data, including details of surgery, were also recorded. Bivariate analysis was conducted using the chi‐square test for proportions and unpaired t‐test/ANOVA to compare the means within groups.Results. We enrolled 175 patients (107 males) with a mean age of 26.1 ± 9.8 years (range: 4‐53 years). We analysed 1,282 seizures, of which 916 (71.5%) were temporal, 95 (7.4%) frontal, 144 (11.2 %) central/ parietal and 19 (1.5%) arose from the occipital lobe. Temporal lobe onset seizures were more frequent during wakefulness (77.7%) compared to extra‐temporal localization (65%) (p<0.0001). Amongst temporal lobe onset seizures, those during wakefulness arose more frequently from the lateral temporal (88.6%) compared to the mesial temporal lobe (75.5%) (p=0.0003). A higher proportion of seizures evolved into secondary generalisation during sleep (23.5%) versus 8.7% during wakefulness (p<0.0001).Significance. Our study demonstrates that lobar location of epileptogenic foci is associated with a predilection of seizures to occur, as well as secondarily generalise, during sleep/wakefulness. Seizures with lateral temporal lobe as well as extratemporal lobe onset were more likely to occur during wakefulness. Overall, sleep related seizures were more likely to be of extratemporal lobe onset, though.
De novo status epilepticus possibly related to battery depletion of anterior thalamic brain stimulator
Authors: Miron Gadi , Strauss Ido , Fahoum Firas 
Published: February 2022

AbstractAnterior thalamic deep brain stimulation is an effective therapeutic option for patients with drug‐refractory focal epilepsy who are poor surgical candidates. Although the precise mechanism of action of thalamic neurostimulation is unknown, studies demonstrating increased efficacy over time have raised the possibility that therapeutic benefits are mediated by stimulation‐related long‐term neuroplastic changes. Adverse effects related to hardware malfunction have been previously described, and most commonly include local infection, sensory disturbances, and migration of leads. However, the withdrawal effect of sudden deep brain stimulation malfunction on seizure control is unclear. We present the case of a 21‐year‐old patient with intractable focal epilepsy who developed status epilepticus concurrently with unexpected deep brain stimulator battery failure, 21 months post implantation. This case demonstrates an unfamiliar possible adverse effect of anterior thalamic stimulation withdrawal and emphasizes the importance of stimulator hardware assessment in patients presenting with seizure worsening.
Determinants of postictal agitation and recovery after tonic‐clonic seizures in generalized and focal epilepsy∗
Authors: Dabir Aman , Zahoor Salman , Abou‐Khalil Bassel W. 
Published: February 2022

AbstractObjective. The postictal state after bilateral tonic‐clonic seizures is often prolonged and can have significant impact on a patient's quality of life. Considerable variability exists in the magnitude of postictal agitation and in the speed of recovery, the determinants of which are not well understood. We studied postictal behavior after tonic‐clonic seizures in various epilepsy localizations, focusing on postictal agitation and time to responsiveness.Methods. We retrospectively identified 15 adult patients each with idiopathic generalized, left temporal lobe, right temporal lobe and frontal lobe epilepsy. Localization in focal epilepsy was validated by good outcome after resective surgery at one‐year of follow‐up. The first tonic‐clonic seizure with reliable video and EEG for each patient was analyzed by two reviewers, one of whom was blinded to clinical data. Clinical, ictal and postictal variables were collected for each patient and analyzed. Postictal agitation was classified as mild and marked.Results. We reviewed 60 tonic‐clonic seizures, 15 in each of four patient groups. Postictal agitation was observed in 14 patients (23.3%; marked in one and mild in 13). Postictal agitation was most common in patients with left temporal (seven patients) and least common in idiopathic generalized epilepsy (one patient) groups (p=0.035). Based on subgroup analysis (n=28), time to responsiveness was 6.6 minutes for frontal, 7.2 minutes for generalized, 10 minutes for right temporal and 15.7 minutes for the left temporal groups (p<0.05 for frontal vs. left temporal, generalized vs. left temporal). Time to responsiveness was longer in patients with agitation than without (13.9 minutes vs. 7.7 minutes; p=0.048). Patient ictal and postictal characteristics demonstrated no relationship to agitation or latency to postictal recovery.Significance. To mitigate harm, patients must be monitored carefully after tonic‐clonic seizures, especially patients with left temporal lobe epilepsy. Studies evaluating medical and behavioral interventions to promote postictal recovery are needed.