bluuebunny/crossref_metadata_2025_split huggingface dataset:
Switchable deep eutectic solvent‐based homogenous liquid–liquid microextraction combined with high‐performance liquid chromatography–diode‐array detection for the determination of the chiral fungicide mefentrifluconazole in water, fruit juice, and fermented liquor
Authors: Jiang Haijuan , Huang Xin , Xue Haoyue , Wang Min , Qi Yanli , Jia Liyan , Jing Xu 
Published: March 2022

AbstractA switchable deep eutectic solvent‐based homogeneous liquid–liquid microextraction (SDES‐HLLME) technique was developed and combined with high‐performance liquid chromatography–diode‐array detection for the determination of the chiral fungicide mefentrifluconazole. A (green) SDES was synthesized from 4‐methoxyphenyl and 3‐amino‐1‐propanol and used as an extraction solvent (thus avoiding the use of toxic extraction solvents). To improve the efficiency of the extraction process, a hydrophobic extraction solvent was subsequently generated in situ by adjusting the pH. The detection process is linear in the range of 0.01 to 1 μg ml−1. The limit of detection and limit of quantification were determined to be 0.003 and 0.01 μg ml−1, respectively. Recovery rates of 79.2% to 104.6% were acquired with relative standard deviations of 0.6% to 2.5%. The method is fast, simple, and environmentally friendly. Moreover, it was successfully used to enantioselectively determine the concentrations of mefentrifluconazole residues in water, fruit juice, and fermented liquor samples.
Development and Optimization of Antisolvent Cooling Coupled Crystallization Process for Coenzyme Q10
Authors: Li Qiuju , Liu Yihang , Liu Baoshu , Sun Hua 
Published: March 2022

AbstractThe solubility of coenzyme Q10 in binary mixed solvents (tetrahydrofuran (THF) + ethanol) is determined at the temperature range from 278.15 to 313.15 K by static high‐performance liquid chromatography. The super‐solubility of coenzyme Q10 at fC = 0.4(C is ethanol), fC = 0.6, fC = 0.8 is measured by dynamic laser method, thus the metastable zone of coenzyme Q10 in binary mixed solvent (THF + ethanol) is obtained. The measurement results show that the solubility of coenzyme Q10 and the width of the metastable zone increase with the increasing of temperature and increasing of THF content in the mixed solvent. Coenzyme Q10 antisolvent cooling coupled crystallization process is developed based on thermodynamic data, and the crystallization conditions are investigated experimentally. The diameter span of crystal size distribution decreases from 5.542 to 1.981 and the median particle size (Dv50) increases from 41.8 to 81.3 μm, which means that the crystal products of coenzyme Q10 are improved by adjusting the crystallization process parameters.
Thermochemical Conversion of Plastic Waste into Fuels, Chemicals, and Value‐Added Materials: A Critical Review and Outlooks
Authors: Yang Ren‐Xuan , Jan Kalsoom , Chen Ching‐Tien , Chen Wan‐Ting , Wu Kevin C.‐W. 
Published: March 2022

AbstractPlastic waste is an emerging environmental issue for our society. Critical action to tackle this problem is to upcycle plastic waste as valuable feedstock. Thermochemical conversion of plastic waste has received growing attention. Although thermochemical conversion is promising for handling mixed plastic waste, it typically occurs at high temperatures (300–800 °C). Catalysts can play a critical role in improving the energy efficiency of thermochemical conversion, promoting targeted reactions, and improving product selectivity. This Review aims to summarize the state‐of‐the‐art of catalytic thermochemical conversions of various types of plastic waste. First, general trends and recent development of catalytic thermochemical conversions including pyrolysis, gasification, hydrothermal processes, and chemolysis of plastic waste into fuels, chemicals, and value‐added materials were reviewed. Second, the status quo for the commercial implementation of thermochemical conversion of plastic waste was summarized. Finally, the current challenges and future perspectives of catalytic thermochemical conversion of plastic waste including the design of sustainable and robust catalysts were discussed.
Cell‐Free Biosynthesis of ω‐Hydroxy Acids Boosted by a Synergistic Combination of Alcohol Dehydrogenases
Authors: Velasco‐Lozano Susana , Santiago‐Arcos Javier , Grazia Rubanu Maria , López‐Gallego Fernando 
Published: March 2022

AbstractThe activity orchestration of an unprecedented cell‐free enzyme system with self‐sufficient cofactor recycling enables the stepwise transformation of aliphatic diols into ω‐hydroxy acids at the expense of molecular oxygen as electron acceptor. The efficiency of the biosynthetic route was maximized when two compatible alcohol dehydrogenases were selected as specialist biocatalysts for each one of the oxidative steps required for the oxidative lactonization of diols. The cell‐free system reached up to 100 % conversion using 100 mM of linear C5 diols and performed the desymmetrization of prochiral branched diols into the corresponding ω‐hydroxy acids with an exquisite enantioselectivity (ee>99 %). Green metrics demonstrate superior sustainability of this system compared to traditional metal catalysts and even to whole cells for the synthesis of 5‐hydroxypetanoic acid. Finally, the cell‐free system was assembled into a consortium of heterogeneous biocatalysts that allowed the enzyme reutilization. This cascade illustrates the potential of systems biocatalysis to access new heterofunctional molecules such as ω‐hydroxy acids.
Punishment sensitivity and the persistence of anorexia nervosa: High punishment sensitivity is related to a less favorable course of anorexia nervosa
Authors: Jonker Nienke C. , Glashouwer Klaske A. , de Jong Peter J. 
Published: March 2022

AbstractObjectiveCross‐sectional research provides robust evidence that individuals with anorexia nervosa (AN) report higher punishment sensitivity (PS) than individuals without an eating disorder (ED). High PS might interfere with treatment motivation and the ability to learn from experience. The current study took a longitudinal approach to test predictions that follow from the proposed relevance of PS as a factor in the persistence of AN symptoms. More specifically we tested (1) if higher PS at the start of treatment was related to less improvement in ED symptoms after one year, and (2) if a decrease in ED symptoms was associated with a concurrent decrease in PS.MethodParticipants were 69 adolescents with a diagnosis of AN at the start of treatment of whom 62 participated again one year later. ED symptom severity and PS were assessed at both time points.ResultsFindings showed that (1) higher PS at the start of treatment was related to less improvement in ED symptoms, and (2) an improvement in ED symptoms was related to a decrease in PS.DiscussionThese findings are consistent with the proposed relevance of PS in the persistence of AN and suggest that it might be beneficial to address high PS in treatment.Public SignificanceConsistent with the view that punishment sensitivity (PS) is related to the persistence of anorexia nervosa, high PS at the start of treatment was related to less improvement in eating disorder symptoms in patients with anorexia nervosa. Furthermore, an improvement in eating disorder symptoms was associated with a concurrent decrease in PS, suggesting that PS can be subject to change and may be a relevant target for treatment.
A new approach to the synthesis of CuFe2O4@CeO2 direct Z‐scheme with a core‐shell structure for enhanced photo‐degradation of methyl violet under ultraviolet and visible‐light irradiation
Authors: Touahra Fouzia , Zemmache Safia , Djema Souhila , Chebout Redouane , Lerari Djahida , Bachari Khaldoun 
Published: March 2022

AbstractA direct Z‐scheme photocatalyst CuFe2O4@CeO2 core‐shell was applied in the photocatalytic degradation of the methyl violet dye 2B (MV). In first, CuFe2O4 and CeO2 were synthesized via sol–gel method, and then CuFe2O4@CeO2 nanocomposite was prepared using microwave process. The nanoparticles were characterized by thermogravimetric analysis (TG and derivative thermogravimetry [DTG]), atomic absorption spectroscopy (AAS), Brunauer–Emmett–Teller (BET) analysis, X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), energy dispersive‐X‐ray (EDX) and ultraviolet (UV)–visible diffuse reflectance/absorption spectroscopy. The photocatalytic activity of CuFe2O4@CeO2 nanocomposite was evaluated by the photo‐degradation of the MV under UV and visible‐light irradiation. MV does not rapidly degrade itself in UV or visible‐light but the process is accelerated upon the addition of semiconductors with a wide band‐gap. The CuFe2O4@CeO2 nanocomposite shows an important MV decomposition rate under visible‐light irradiation (95.35% within 1.5 h) as compared to UV‐light (86.10% within 2.5 h). The excellent activity of CuFe2O4@CeO2 under UV and visible‐light was mainly attributed to direct Z‐scheme which are originated from a core‐shell structure which prompted the generation of ˙OH radical species responsible for the photo‐degradation of the substance. However, this could also be due to the large specific surface area and/or efficient UV–vis harvesting.
Subsampled factor models for asset pricing: The rise of Vasa
Authors: De Nard Gianluca , Hediger Simon , Leippold Markus 
Published: March 2022

AbstractWe propose a new method, variable subsample aggregation (VASA), for equity return prediction using a large‐dimensional set of factors. To demonstrate the effectiveness, robustness, and dimension reduction power of VASA, we perform a comparative analysis between state‐of‐the‐art machine learning algorithms. As a performance measure, we explore not only the global predictive but also the stock‐specific 's and their distribution. While the global reflects the average forecasting accuracy, we find that high variability in stock‐specific 's can be detrimental for the portfolio performance. Since VASA shows minimal variability, portfolios formed on this method outperform the portfolios based on random forests and neural nets.
Protective effects of dietary Kefir against aflatoxin B1‐induced hepatotoxicity in Nile tilapia fish, Oreochromis niloticus
Authors: Ben Taheur Fadia , Mansour Chalbia , Mechri Sondes , Laaouar Houcine , Safta Skhiri Sihem , Bouricha Mohamed , Jaouadi Bassem , Mzoughi Ridha , Zouari Nacim 
Published: March 2022

AbstractThe effect of dietary Kefir supplementation on the biometric, biochemical, and histological parameters of Nile tilapia (Oreochromis niloticus) exposed to aflatoxin B1 (AFB1, 200 µg/kg diet) contamination was studied. The yeasts were dominant in Kefir followed by lactic and acetic acid bacteria. The Kefir showed relatively interesting antioxidant potential in the DPPH• (IC50 = 0.9 ± 0.02 mg/ml) and ABTS•+ (IC50 = 2.2 ± 0.03 mg/ml) scavenging activities, Fe3+‐reducing power (EC0.5 = 1.2 ± 0.01 mg/ml), and β‐carotene bleaching assay (IC50 = 3.3 ± 0.02 mg/ml). Three hundred and sixty Nile tilapia weighing 23 ± 5 g were divided into four groups (30 fish/group with 3 replicates), and fed with diets containing Kefir (D2), AFB1 (D3), and Kefir+AFB1 (D4) for 4 weeks, whereas D1 was kept as control group where fish were fed with basal diet. The Kefir supplementation in D4 group significantly increased (p < .05) the percent weight gain as compared to D3 group. Moreover, Kefir improved the antioxidant enzymes in the liver, such as catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities, that significantly increased (p < .05) by 2‐, 3‐, and 1.5‐folds, respectively, as compared to D3 group. The Kefir treatment significantly decreased (p < .05) the liver malonaldehyde content by ~50% as compared to D3 group. Histopathological analysis revealed the hepatoprotective effects of Kefir by showing normal liver histological architecture in D4 group, as compared to degenerative changes observed in D3 group. These results suggest that Kefir could be considered as a potential probiotic in Nile tilapia feed to mitigate the AFB1 harmful effects.
The importance of rare events and other outliers in global strategy research
Authors: Beamish Paul W. , Hasse Vanessa C. 
Published: March 2022

AbstractResearch SummaryRare events and other nonerror outliers (such as the COVID‐19 pandemic) are important phenomena in global strategy contexts. Despite their salience, however, they have hardly been studied systematically in our field (or organizational research at large). We suggest that this is due to a dominance of the Gaussian paradigm, which (often unrealistically) assumes linearity and independence of observations. Moreover, case‐based qualitative studies which offer contextualization have been underrepresented. We thus call on researchers to abolish the practice of habitually discarding outliers, reflect on nonnormal distributions, and pursue more qualitative studies. Journal editors and reviewers should widen their assumptions regarding “acceptable” papers and reflect on the requirement of contributing to big “T” theories. Finally, PhD training should juxtapose fundamental paradigms and associated implications for epistemological choices.Managerial SummaryExtreme occurrences, such as organizational crises, recessions, or pandemics, are challenges most practitioners deal with and worry about. Understanding their determinants, characteristics, and dynamics allows for heightened vigilance, preparedness, and ultimately performance. Yet, much of global strategy research (and organizational research at large) has focused on “average” phenomena, based on methodologies that assume bell‐shaped distributions and independent observations. In this note, we argue that this is not a realistic way to think about most social phenomena. In fact, most are characterized by their high degree of interdependence among elements, as well as a relative commonness of “rare” events and outliers. As a result of embracing the reality of nonnormality, scholars will be able to offer more relevant guidance to practitioners.
Consensus subtypes of hepatocellular carcinoma associated with clinical outcomes and genomic phenotypes
Authors: Lee Sung Hwan , Yim Sun Young , Jeong Yun Seong , Li Qi‐Xiang , Kang Sang‐Hee , Sohn Bo Hwa , Kumar Shwetha V. , Shin Ji‐Hyun , Choi You Rhee , Shim Jae‐Jun , Kim Hayeon , Kim Ji Hoon , Kim Shin , Guo Sheng , Johnson Randy L. , Kaseb Ahmed , Kang Koo Jeong , Chun Yun Shin , Jang Hee Jin , Lee Byoung Gill , Woo Hyun Goo , Ha Min Jin , Akbani Rehan , Roberts Lewis R. , Wheeler David A. , Lee Ju‐Seog 
Published: March 2022

Abstract

Background and Aims
Although many studies revealed transcriptomic subtypes of HCC, concordance of the subtypes are not fully examined. We aim to examine a consensus of transcriptomic subtypes and correlate them with clinical outcomes.

Approach and Results
By integrating 16 previously established genomic signatures for HCC subtypes, we identified five clinically and molecularly distinct consensus subtypes. STM (STeM) is characterized by high stem cell features, vascular invasion, and poor prognosis. CIN (Chromosomal INstability) has moderate stem cell features, but high genomic instability and low immune activity. IMH (IMmune High) is characterized by high immune activity. BCM (Beta‐Catenin with high Male predominance) is characterized by prominent β‐catenin activation, low miRNA expression, hypomethylation, and high sensitivity to sorafenib. DLP (Differentiated and Low Proliferation) is differentiated with high hepatocyte nuclear factor 4A activity. We also developed and validated a robust predictor of consensus subtype with 100 genes and demonstrated that five subtypes were well conserved in patient‐derived xenograft models and cell lines. By analyzing serum proteomic data from the same patients, we further identified potential serum biomarkers that can stratify patients into subtypes.

Conclusions
Five HCC subtypes are correlated with genomic phenotypes and clinical outcomes and highly conserved in preclinical models, providing a framework for selecting the most appropriate models for preclinical studies.
Viewpoint: Irrigation water management in a space age
Authors: Hafeez Mohsin , Awan Usman Khalid 
Published: March 2022

AbstractClimate change and rapid population growth are already putting increasing demand and pressure on the world's freshwater resources. Irrigated agriculture is responsible for about 70% of global freshwater withdrawals, consuming the most amount of water. However, the diverted water in irrigation systems is often not utilized efficiently because of poor water management at different spatial scales, resulting in a system efficiency of only 30–50% in most Asian countries. Typically, improving water management in irrigated areas requires accurate information on various water balance parameters while also considering a changing climate across different spatial scales. There have been technical limitations in getting accurate and reliable information on various key water balance parameters with the conventional approaches used in the recent past. In the twenty‐first century, considerable advances have been made in using satellite imagery, including processing and geospatial algorithms, to estimate hydro‐meteorological fluxes and relevant components at different spatial scales. This paper provides a perspective on the application of innovative and non‐conventional approaches to water resources management in the Murray Darling basin, Australia, the Indus basin, Pakistan and the Amu Darya basin, Uzbekistan. Examples of the state‐of‐the‐art tools described in this paper include: (i) using geoinformatics to monitor the diagnostic and operational performance of large irrigation schemes; (ii) quantifying groundwater and surface water to better manage these two resources using geoinformatics; (iii) forecasting irrigation supply and demand at high spatial and temporal scales using hydrological modelling based on the nodal network; (iv) forecasting crop yield production by satellite remote sensing. The approaches in this study clearly demonstrate that new monitoring and planning tools and methods are highly effective in improving irrigation water management in the ‘space age’ (for the purposes of this paper, space age refers to a period in which earth observation satellites are available to accurately monitor agricultural practices and water balance parameters such as soil moisture and evapotranspiration). The application of these innovative tools can assist in strategizing, diagnosing, monitoring and improving the performance of irrigation systems to grow more crop per drop of water while minimizing environmental impacts and dealing with climate change impacts.
RUMA and RUPCR in children with Henoch–Schonlein purpura
Authors: Han Xiucui , Xu Pengfei 
Published: March 2022

AbstractObjectiveThe aim of this study was to compare the qualitative and quantitative targets in the detection of proteinuria in children with HSP.MethodsThree hundred and forty children were taken as the research subjects. Qualitative and a series of quantitative indicators of urine protein were tested.ResultsThe qualitative and quantitative of protein in 340 children were analyzed retrospectively. Correlation analysis found that 24hUTP had a strong correlation with age, RUMA, RUPCR, and qualitative urine occult blood (p < 0.01, for all). After regression analysis, RUMA and RUPCR were still significantly correlated with 24hUTP (p < 0.01). At the same time, RUMA and RUPCR had good diagnostic accuracy for proteinuria. When the RUPCR ratio was set as 0.415, the diagnostic sensitivity was 83%, and the specificity was 98.7%. When RUMA was set as 68.215, the sensitivity was 94.3% and the specificity was 96.2%.ConclusionCompared with 24hUTP, RUMA and RUPCR had high sensitivity and specificity for monitoring proteinuria in children with HSP.
Pharyngodon mamillatus (Nematoda: Pharyngodonidae) in the ocellated skink Chalcides ocellatus (Squamata: Scincidae) from Egypt: Light and scanning electron microscopic studies
Authors: Abdel‐Ghaffar Fathy , Varjabedian Kohar Garo , Fol Mona , Talal Noha , Al Quraishy Saleh , Abdel‐Gaber Rewaida 
Published: March 2022

AbstractTwenty‐one Pharyngodon mamillatus were recovered from the large intestine of 4 out of 12 ocellated skink Chalcides ocellatus collected from the South Sinai desert, Egypt. The prevalence of infection was 33.33% (intensity 2–4). The recovered pharyngodonid was re‐described based on light and scanning electron microscopy. According to the morphology, it was characterized by regular transverse annulations extending from the posterior margin of the lips to the level of the anus, triangular mouth opening was surrounded by three large bilobed lips possessing three papillae, oval‐shaped excretory pore, slit‐like vulva opening, and slit‐like anal ventral opening at the posterior end which terminates with a tail filament. Here, the morphometric measurements of adult female P. mamillatus were given in this study. It has no intraspecific morphological variations from the previously described P. mamillatus, but it appeared with small range on biometric features. These variations may be accounted by host/environment attributes since they exhibit wide host and geographical spectra. The present study was applied for detailed morphological knowledge of the recovered P. mamillatus for strengthening their taxonomic validity.Highlights
The Pharyngodon mamillatus naturally parasite of the intestinal region of Chalcides ocellatus.
The present study clarifies the morphological key for the description of P. mamillatus.
Cross‐racial interactions in the counselor education classroom: The impact of racial perception
Authors: Walker Tanesha L. , Bruns Kristin L. 
Published: March 2022

AbstractWhile research exists on the experiences of African American counselor educators, little research has explored student perceptions of this population in the classroom setting. This study used an interpretative phenomenological analysis to explore the experiences of White counseling students who have taken a course with an African American counselor educator. Two themes were identified related to racial perception. Implications for counselor education leadership, African American counselor educators, and program curriculum are discussed.
Schools as jails: Urban African American Adolescent Males’ (UAAM) experiences and perceptions of violence in low‐income public schools
Authors: Outland Rafael 
Published: March 2022

AbstractThis manuscript presents urban African American adolescent males’ (UAAM) experiences and perceptions of violence in low‐income public schools. Findings derived from a qualitative study that investigated the meanings and experiences of violence among UAAM. Nine and six UAAM participated in in‐depth phenomenological interviews and a focus group, respectively. Findings revealed that UAAM experience and perceive school as a site for criminalizing their behaviors, peer fights, and being undereducated by teachers. Implications for counselors, educators, and service providers are discussed.