Heterogeneity in the association between prediabetes categories and reduction on glomerular filtration rate in a 5-year follow-up
Authors: Manouchehri Marjan , Cea-Soriano Lucía , Franch-Nadal Josep , Ruiz Antonio , Goday Albert , Villanueva Rosa , Diez-Espino Javier , Mata-Cases Manel , Giraldez-García Carolina , Regidor Enrique ,   The PREDAPS Study Group, Torrecilla Jesús , Carrillo Lourdes , Mancera José , Mur Teresa , Serrano Rosario , Javier García-Soidán F. , Cuatrecasas Gabriel , Igual Dimas , Moreno Ana , Manuel Millaruelo J. , Carramiñana Francisco , Antonio Ruiz Manuel , Pérez Francisco Carlos , Iriarte Yon , Lorenzo Ángela , González María , Álvarez Beatriz , Barutell Lourdes , Mayayo Ma Soledad , Del Castillo Mercedes , Navarro Emma , Malo Fernando , Cambra Ainoha , Magallón Rosa , López Riánsares , Ángel Gutiérrez M. , Gutiérrez Luisa , Boente Carmen , Javier Mediavilla J. , Prieto Luis , Mendo Luis , José Mansilla Ma , Ortega Francisco Javier , Borras Antonia , Sánchez L. Gabriel , Obaya J. Carlos , Alonso Margarita , García Francisco , Trinidad Gutiérrez Ángela , Hernández Ana Ma , Suárez Dulce , Carlos Álvarez J. , Sáenz Isabel , Martínez F. Javier , Casorrán Ana , Ripoll Jazmín , Salanova Alejandro , Marín Ma Teresa , Gutiérrez Félix , Innenaraty Jaime , del Mar Álvarez Ma , Artola Sara , Bedoya Ma Jesús , Poveda Santiago , Álvarez Fernando , Jesús Brito Ma , Iglesias Rosario , Paniagua Francisca , Nogales Pedro , Gómez Ángel , Félix Rubio Jóse , Durán Ma Carmen , Sagredo Julio , Teresa Gijón Ma , Rollán Ma Angeles , Pérez Pedro P. , Gamarra Javier , Carbonell Francisco , García-Giralda Luis , Antón J. Joaquín , De la Flor Manuel , Martínez Rosario , Pardo José Luis , Plana Raquel , Macía Ramón , Villaró Mercè , Babace Carmen , Blanco Concepción , Jurado Ángeles , Martín José Luis , Navarro Jorge , Sanz Gloria , Colas Rafael , Cordero Blanca , De Castro Cristina , Ibáñez Mercedes , Monzón Alicia , Porta Nuria , del Carmen Gómez María , Llanes Rafael , Rodríguez J. José , Granero Esteban , Sánchez Manuel , Martínez Juan , Ezkurra Patxi , Ávila Luis , De la Sen Carlos , Rodríguez Antonio , Buil Pilar , Gabriel Paula , Roura Pilar , Tarragó Eduard , Mundet Xavier , Bosch Remei , González J. Carles , Bobé Ma Isabel , Ruiz Irene , López Flora , Martínez Ana , Birules Marti , Armengol Oriol , De MarMiguel Rosa , Romera Laura , Benito Belén , Piulats Neus , Bilbeny Beatriz , Cabré J. José , Cos Xavier , Pujol Ramón , Seguí Mateu , Losada Carmen , De MaríaSantiago A. , Muñoz Pedro 
Published: May 2022

Abstract Prediabetes and not just diabetes can cause kidney damage. This study assess the association of prediabetes with development of impaired renal function (IRF). We used data from PREDAPS prospective study a cohort of 1072 subjects with prediabetes and another cohort of 772 subjects without prediabetes were follow-up from 2012 to 2017. Prediabetes was defined according to American Association of Diabetes criteria. IRF was defined as having a glomerular filtration rate < 60 mL/min/1.73 m2. Incidence rates of IRF in both cohorts and in different categories of prediabetes, based on impaired glycosylated hemoglobin (HbA1c) and/or fasting plasma glucose (FPG), were calculated. Hazard ratios (HR) for the association of the prediabetes with IRF, adjusting for potential confounders, were estimated by Cox regression models. Incidence rates of IRF per 100 person-years were 1.72 (95% confidence interval [CI]: 1.34–2.21) and 1.79 (95%CI: 1.45–2.20) for those without and with prediabetes, respectively .The HR of IRF in subjects with prediabetes with respect to subjects without prediabetes was 0.76 (95% CI: 0. 54–1.07). Corresponding HRs for type of prediabetes was 0.68 (95%CI: 0.40–1.15) for those with both altered parameters, 0.68 (95%CI: 00.40–1.15) for those with only impaired HbA1c and 1.12 (95%CI: 0.68–1.85) for those with only impaired FPG. The present study reflects an overall trend towards a slightly decreased risk of IRF onset associated to prediabetes except for individuals with only isolated impaired FPG. Further studies are warranted to fully assess the renal progression of each group.