bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex/gender differences in children with autism spectrum disorder: A brief overview on epidemiology, symptom profile, and neuroanatomy
Authors: Calderoni Sara 
Published: January 2022

AbstractAutism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental conditions whose shared core features are impairments in social interaction and communication as well as restricted patterns of behavior, interests, and activities. The significant and consistent male preponderance in ASD prevalence has historically affected the scientific knowledge of autism in females as regards, inter alia, the clinical presentation, the genetic architecture, and the structural brain underpinnings. Indeed, females with ASD are under‐investigated as samples recruited for clinical research typically reflect the strong male bias of the disorder. In the last years, the study of the various aspects of sex/gender (s/g) differences in ASD is gaining increased clinical and research interest resulting in a growing number of investigations on this topic. Here, I review and discuss evidence emerged from epidemiological, clinical, and neuroimaging studies in the last decade focusing on s/g differences in children with ASD. These studies are the prerequisites for the development of assessment and treatment practices which take into consideration s/g differences in ASD. Ultimately, a better understanding of s/g differences aims at improving healthcare for both ASD males and females.
Dose‐dependent effect of myelin oligodendrocyte glycoprotein on visual function and optic nerve damage in experimental autoimmune encephalomyelitis
Authors: Castoldi Valerio , Marenna Silvia , Huang Su‐Chun , d’Isa Raffaele , Chaabane Linda , Comi Giancarlo , Leocani Letizia 
Published: January 2022

AbstractFemale Dark Agouti rats were immunized with increasing doses of myelin oligodendrocyte glycoprotein (MOG) to develop experimental autoimmune encephalomyelitis (EAE), a preclinical model of multiple sclerosis. Typical EAE motor impairments were assessed daily and noninvasive visual evoked potentials (VEPs) were recorded at baseline and 5 weeks after immunization, with final histopathology of optic nerves (ONs). Immunized rats exhibited a relapsing‐remitting clinical course. Both VEP and histological abnormalities were detected in a MOG dose‐dependent gradient. Increasing MOG dosage augmented visual function impairment in EAE, which could be monitored with VEP recording to assess demyelination and axonal loss along ONs.
Sex and gender differences in the development of empathy
Authors: Rochat Magali Jane 
Published: January 2022

AbstractThe topic of typical sex and gender difference in empathy is examined in both a developmental and neuroscientific perspective. Empathy is construed as a multi‐layered phenomenon with various degrees of complexity unfolding in ontogeny. The different components of empathy (i.e., affective, cognitive, and prosocial motivation) will be discussed as they interact and are expressed behaviorally. Significant sex/gender differences in empathy are discussed in relation to putative bottom‐up or top‐down processes underlying empathetic responses. The early onset and the pervasive presence of such sex/gender differences throughout the lifespan are further discussed in light of social and neurobiological modeling factors, including early socialization, brain's structural/functional variances, as well as genetics and hormonal factors.
The serotonin reuptake transporter modulates mitochondrial copy number and mitochondrial respiratory complex gene expression in the frontal cortex and cerebellum in a sexually dimorphic manner
Authors: Thorne Bryony N. , Ellenbroek Bart A. , Day Darren J. 
Published: January 2022

AbstractNeuropsychiatric and neurodevelopmental disorders such as major depressive disorder (MDD) and autism spectrum disorder (ASD) are complex conditions attributed to both genetic and environmental factors. There is a growing body of evidence showing that serotonergic signaling and mitochondrial dysfunction contribute to the pathophysiology of these disorders and are linked as signaling through specific serotonin (5‐HT) receptors drives mitochondrial biogenesis. The serotonin transporter (SERT) is important in these disorders as it regulates synaptic serotonin and therapeutically is the target of selective serotonin reuptake inhibitors which are a major class of anti‐depressant drug. Human allelic variants of the serotonin transporter‐linked polymorphic region (5‐HTTLPR) such as the S/S variant, are associated with reduced SERT expression and increased susceptibility for developing neuropsychiatric disorders. Using a rat model that is haploinsufficient for SERT and displays reduced SERT expression similar to the human S/S variant, we demonstrate that reduced SERT expression modulates mitochondrial copy number and expression of respiratory chain electron transfer components in the brain. In the frontal cortex, genotype‐related trends were opposing for males and females, such that reduced SERT expression led to increased expression of the Complex I subunit mt‐Nd1 in males but reduced expression in females. Our findings suggest that SERT expression and serotonergic signaling have a role in regulating mitochondrial biogenesis and adenosine triphosphate (ATP) production in the brain. We speculate that the sexual dimorphism in mitochondrial abundance and gene expression contributes to the sex bias found in the incidence of neuropsychiatric disorders such as MDD and ASD.
The Impact of a Laughter Prescription on Creativity, Well‐Being, Affect, and Academic Efficacy in University Students
Authors: Sharma Ekta , Sharma Sandeep , Gonot‐Schoupinsky Xavier P. , Gonot‐Schoupinsky Freda N. 
Published: January 2022

AbstractOur study explored: (a) the feasibility of prescribing laughter to university students; (b) the efficacy of the prescription on creativity, well‐being, affect, and academic efficacy (AE); and (c) the practicality of the Applied Creativity Test (ACT) conceived for this study. A convenience sample of healthy students (n = 70) aged 18–28 (78% female; M = 21.6) was randomized to experimental or control conditions. Experimental participants (n = 29) were prescribed to laugh three times a day for a week with their Laughie (a 1‐minute recording, on their smartphone, of their laughter). The intervention was planned and evaluated using Feasibility, Reach‐out, Acceptability, Maintenance, Effectiveness, Implementation, Tailorability. Data measures included ACT, Wallach–Kogan Creativity Test, Kaufman Domains of Creativity Scale, WHO‐5 Well‐being Index (WHO‐5), and Pattern of Adaptive Learning Scales AE and avoiding novelty. A 1‐minute laughter prescription, used three times a day for 1 week, was feasible and effective in stimulating creativity, increasing well‐being and immediate affect, and benefitting AE.
Sustainability co‐creation in digitalized global value chains
Authors: Grunwald Guido 
Published: January 2022

AbstractIncreased attention to sustainability issues and advancing digitalization motivate organizations to collaborate on sustainability issues in projects with various stakeholders in and around global value chains. In sustainability co‐creation, stakeholders' specific knowledge and competencies will be combined to achieve common sustainability goals more effectively while better targeting individual goals. However, sustainability co‐creation can pose various challenges that affect the possible input factors (e.g., insufficient or unequal digital resources, skills, motivation), the process of cooperation (e.g., conflicting goals, inappropriate timing and methods) and the output (e.g., lack of commitment about target achievement and communication). This paper proposes a conceptual input–process–output framework of sustainability co‐creation in the context of digitalized global value chains. It highlights major managerial challenges and implications drawing on relationship marketing research. Recommendations and practical examples for designing sustainability co‐creation's input, process, and output are provided, useful for managers. Besides, avenues for future research are derived.
The influence of blockchains and internet of things on global value chain
Authors: Egwuonwu Arthur , Mordi Chima , Egwuonwu Ambrose , Uadiale Olayinka 
Published: January 2022

AbstractDespite the increasing proliferation of deploying the internet of things (IoT) in the global value chain (GVC), several challenges might lead to a lack of trust among value chain partners, for example, technical challenges (i.e., confidentiality, authenticity, and privacy); and security challenges (i.e., counterfeiting, physical tampering, and data theft). In this study, we argue that blockchain technology (BT), when combined with the IoT ecosystem, will strengthen GVC and enhance value creation and capture among value chain partners. Therefore, we examine the impact of BT combined with the IoT ecosystem and how it can be utilized to enhance value creation and capture among value chain partners. We collected data through an online survey, and 265 U.K. Agri‐food retailers completed the survey. Our data were analyzed using structural equation modeling. Our finding reveals that BT enhances GVC by improving IoT scalability, security, and traceability combined with the IoT ecosystem. Moreover, the combination of BT and IoT strengthens GVC and creates more value for value chain partners, which serves as a competitive advantage. Finally, our research outlines the theoretical and practical contribution of combining BT and the IoT ecosystem.
Global value chains and digital platforms: Implications for strategy
Authors: Loonam John , O'Regan Nicholas 
Published: January 2022

AbstractThe emergence of global value chains (GVCs) appears due to the rise of international trade deregulation and market liberalization over the past decades. The rise of information and communication technologies, which supports knowledge‐intensive activities, has also radically transformed value capture across GVCs and raises the bar for value‐creating opportunities as a new generation of technologies emerges. Of particular relevance to GVCs is the rise of digital technologies, such as big data, the Internet of Things, and artificial intelligence. These technologies promise to herald a new era of connectedness, collaboration, and innovation, affording significant growth opportunities for GVCs. Digital platforms will play a key role for GVCs in orchestrating such value‐creating opportunities. There remains a lack of empirical understanding of how digital platforms can enable GVC strategy. The study seeks to address this question by reviewing the digital platform literature to support key GVC strategy learnings. Specifically, 61 “digital platform”–titled articles across 38 Chartered Association of Business Schools (ABS)‐ranked journals were reviewed. The study adopts Mainardi and Kleiner's (Strategy + Business, 2010, 61, pp. 1–14) “strategy landscape” framework to organize emerging findings. Eight key themes emerged from the literature to reveal critical issues for digital platforms. Implications for strategy are then discussed, revealing four key learnings for GVCs, namely, (i) boundary management, (ii) definition of the unit of analysis, (iii) alignment of capabilities, and (iv) governance and leadership.
A case of trust‐building in the supply chain: Emerging economies perspective
Authors: Manfredi Emilia , Capik Paweł 
Published: January 2022

AbstractThe paper explores the process of trust‐building between SMEs' supply chain partners in turbulent times in emerging economies. It focuses on the role of environmental information exchange in strengthening relationships and improving responsiveness to overcome uncertainty while understanding and adapting to the changing environmental realities. A case study strategy of an SME in Argentina was conducted to obtain insights regarding the experiences, perceptions and opinions about how achieving trust acts as an instrument of partners' support during an uncertain time. A series of semi‐structured interviews were conducted in Argentina and China to collect empirical data. Data were analyzed to understand partners' mutual support and the emergence of trust. The importance of supply chain partnership is that partners go to the market together, meaning that there are more opportunities to benefit from for each partner. The results demonstrate that it is incorrect to assume that an SME can prosper alone in an unknown landscape. However, because of their responsiveness and experience in operating in a turbulent working environment, decision‐makers rapidly develop skills to adapt to uncertainty. Information sharing is at the core of establishing successful long‐term relationships, overcoming uncertainties while transforming them into opportunities.
Molecular encapsulation and bioactivity of gnetol, a resveratrol analogue, for use in foods
Authors: Navarro‐Orcajada Silvia , Conesa Irene , Matencio Adrián , García‐Carmona Francisco , López‐Nicolás José Manuel 
Published: January 2022

AbstractBACKGROUNDGnetol is a stilbene whose characterization and bioactivity have been poorly studied. It shares some bioactivities with its analogue resveratrol, such as anti‐inflammatory, anti‐thrombotic, cardioprotective and anti‐cancer activities. However, the low solubility of stilbenes may limit their potential applications in functional foods. Encapsulation in cyclodextrins could be a solution.RESULTSThe antioxidant activity of gnetol was evaluated by 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) radical cation and ferric reducing antioxidant power methods (Trolox equivalents 13.48 μmol L−1 and 37.08 μmol L−1 respectively at the highest concentration) and it was higher than that of resveratrol, and depending on the method, similar or higher to that of oxyresveratrol. Spectrophotometric and spectrofluorimetric characterization of gnetol is published for the first time. Moreover, its water solubility was determined and improved almost threefold after its molecular encapsulation in cyclodextrins, as well as its stability after storage for a week. A physicochemical and computational study revealed that cyclodextrins complex gnetol in a 1:1 stoichiometry, with better affinity for like 2‐hydroxypropyl‐β‐cyclodextrin (KF = 4542.90 ± 227.15 mol−1 L). Temperature and pH affected the encapsulation constants.CONCLUSIONThese results could increase interest of gnetol as an alternative to the most studied stilbene, resveratrol, as well as aid in the development of more stable inclusion complexes that improve its aqueous solubility and stability so that it can be incorporated into functional foods. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Neck Imaging Reporting and Data System Category 3 on Surveillance Computed Tomography: Incidence, Biopsy Rate, and Predictive Performance in Head and Neck Squamous Cell Carcinoma
Authors: Johansson Erik D. , Hughes Ryan T. , Meegalla Nuwan T. , Porosnicu Mercedes , Patwa Hafiz S. , Lack Christopher M. , Bunch Paul M. 
Published: January 2022

ObjectivesNeck Imaging Reporting and Data System (NI‐RADS) is a radiology reporting system for head and neck cancer surveillance. Imaging findings of high suspicion for recurrence are assigned Category 3 and recommended for “Biopsy, if clinically indicated.” After implementing NI‐RADS for surveillance neck computed tomography (CT), our objectives are to determine the incidence of squamous cell carcinoma (SCC) Category 3 lesions in the year post‐implementation, the associated biopsy rate, and the positive predictive value of NI‐RADS 3 for SCC recurrence.Study DesignRetrospective cohort study.MethodsNeck CTs reported with NI‐RADS between February 2020 and February 2021 were reviewed to identify patients undergoing surveillance for SCC assigned NI‐RADS 3. Cancer recurrence, defined as positive biopsy result or treatment of clinically determined recurrence, was determined by electronic medical record review.ResultsDuring the study period, 580 neck CTs were reported with NI‐RADS, of which 39 (7%) CTs obtained in 37 unique patients (28 male, 9 female, mean age 66.6 years) formed the study cohort. Biopsies were obtained in 23 lesions (45%), of which 17 (74%) were positive for recurrent SCC. One nondiagnostic biopsy was clinically determined to represent recurrence. Of 28 (55%) lesions not biopsied, 18 (64%) were ultimately treated as clinically determined recurrence. Thus, among 51 individual NI‐RADS 3 lesions (32 primary, 19 neck), 36 (71%) represented recurrence.ConclusionThe incidence of NI‐RADS 3 lesions in our cohort was 7%. The biopsy rate was 45%, and the overall positive predictive value of NI‐RADS 3 for recurrent SCC was 71%. Category 3 lesions are associated with substantial SCC recurrence risk and should be managed accordingly.Level of Evidence4 Laryngoscope, 132:1792–1797, 2022
Research data policies of journals in the Chinese Science Citation Database based on the language, publisher, discipline, access model and metrics
Authors: Wang Yu , Chen Beibei , Zhao Liangbin , Zeng Yuanxiang 
Published: January 2022

AbstractThis article investigates the research data policies of China's scholarly journals to provide a regional perspective. In total, 1243 science, technology, and medicine (STM) journals in the Chinese Science Citation Database (CSCD) were examined in June and July of 2021. The findings show that the existence and attitudinal strength of the research data policies of China's scholarly journals are weak overall, but differences exist across journals with different languages, publishers, disciplines, access models and metrics. A large imbalance exists between English‐language journals and Chinese‐language journals in setting their research data policies. The existence and attitudinal strength of the research data policies of journals co‐published by Western publishers and Chinese publishers are much stronger than those of journals published solely by Chinese publishers. In terms of discipline, journals belonging to the life sciences have stronger attitudes towards research data sharing. Open access model journals and hybrid model journals are better than subscription model journals in opening and sharing research data. The higher the impact factor (IF) and CiteScore of a journal, the more likely the journal is to have data policies.
Implementing an Open & FAIR data sharing policy—A case study in the earth and environmental sciences
Authors: Cannon Matthew , Kelly Andrew , Freeman Chris 
Published: January 2022

AbstractThis paper outlines the impact of the introduction of an Open & FAIR (findable, accessible, interoperable, and reusable) data sharing policy on six earth and environmental science journals published by Taylor & Francis, beginning in November 2019. Notably, 18 months after implementing this new policy, we observed minimal impacts on submission, acceptance rates, or peer‐review times for the participating journals. This paper describes the changes that were required to internal systems and processes in order to implement the new policy, and compares our findings with recent literature reports on the impact of journals introducing data‐sharing policies.
Suicidal thoughts in patients with empty nose syndrome
Authors: Huang Chien‐Chia , Wu Pei‐Wen , Lee Cheng‐Chi , Chang Po‐Hung , Huang Chi‐Che , Lee Ta‐Jen 
Published: January 2022

AbstractObjectivesPatients with empty nose syndrome (ENS) suffer from paradoxical nasal obstruction with a patent objective nasal airway. ENS may result from the excessive surgical reduction of the turbinate tissue. ENS patients also experience significant psychological symptoms such as anxiety and depression. In this study, we aimed to evaluate the prevalence of suicidal thoughts in ENS patients and to characterize these patients for early identification.Study DesignProspective case series.MethodsPatients with ENS were prospectively recruited for this study. The Sino‐Nasal Outcome Test‐25 (SNOT‐25), Empty Nose Syndrome 6‐item Questionnaire (ENS6Q), Beck Anxiety Inventory (BAI), and Beck Depression Inventory‐II (BDI‐II) were used to assess ENS patients before and 6 months after nasal reconstruction surgery.ResultsSixty‐two patients with ENS were enrolled. Suicidal thoughts were identified in 23 ENS patients preoperatively and in four patients postoperatively. ENS patients with suicidal thoughts rated significantly higher in the SNOT‐25, ENS6Q, BDI‐II, and BAI total scores than those without suicidal thoughts (all P < .05). “Nose feels too open” was the item in ENS6Q that was significantly more severe in ENS patients with suicidal thoughts than those without suicidal thoughts (P < .001).ConclusionsSuicidal thoughts are frequently identified in patients with ENS. ENS patients with suicidal thoughts experienced significantly more severe symptoms, impaired quality of life, and psychological burden than those without suicidal thoughts. Recognizing individuals who may carry suicidal thoughts and provide appropriate psychological interventions is critical to prevent tragedy.Level of Evidence4
A hybrid optimization strategy for deliverable intensity‐modulated radiotherapy plan generation using deep learning‐based dose prediction
Authors: Sun Zihan , Xia Xiang , Fan Jiawei , Zhao Jun , Zhang Kang , Wang Jiazhou , Hu Weigang 
Published: January 2022

AbstractPurposeTo propose a clinically feasible automatic planning solution for external beam intensity‐modulated radiotherapy, including dose prediction via a deep learning and voxel‐based optimization strategy.Materials and methodsThe dose distribution of patients was predicted using a U‐Net‐based deep learning network based on the patient's anatomy information. One hundred seventeen patients with nasopharyngeal cancer (NPC) and 200 patients with rectal cancer were enrolled in this study. For NPC cases, 94 cases were included in the training dataset, 13 in the validation dataset, and 10 in the testing dataset. For rectal cancer cases, 172 cases were included in the training set, 18 in the validation set, and 10 in the testing set. A voxel‐based optimization strategy, “Voxel,” was proposed to achieve treatment planning optimization by dividing body voxels into two parts: inside planning target volumes (PTVs) and outside PTVs. Fixed dose‐volume objectives were attached to the total objective function to realize individualized planning intended as the “hybrid” optimizing strategy. Automatically generated plans were compared with clinically approved plans to evaluate clinical gains, according to dosimetric indices and dose‐volume histograms (DVHs).ResultsSimilarities were found between the DVH of the predicted dose and clinical plan, although significant differences were found in some organs at risk. Better organ sparing and suboptimal PTV coverage were shown using the voxel strategy; however, the deviations in homogeneity indices (HIs) and conformity indices (CIs) of the PTV between automatically generated plans and manual plans were reduced by the hybrid strategy ([manual plans]/[voxel plans[/[hybrid plans]: HI of PTV70 [1.06/1.12/1.02] and CI of PTV70 [0.79/0.58/0.76]). The optimization time for each patient was within 1 min and included fluence map optimization, leaf sequencing, and control point optimization. All the generated plans (voxel and hybrid strategy) could be delivered on uRT‐linac 506c (United Imaging Healthcare, Shanghai, China).ConclusionDeliverable plans can be generated by incorporating a voxel‐based optimization strategy into a commercial treatment planning system (TPS). The hybrid optimization method shows the benefit and clinical feasibility in generating clinically acceptable plans.