bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and Outcomes of Clinical Trials on Gene Therapy in Noncongenital Cardiovascular Diseases: Cross-sectional Study of Three Clinical Trial Registries
Authors: Pinczak Witold , Trzcińska Sylwia , Kamiński Mikołaj 
Published: March 2022

Background
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Gene therapies (GTs) may become a novel therapeutic option for cardiovascular diseases.

Objective
We aimed to characterize all trials involving human subjects utilizing GT to treat noncongenital cardiovascular diseases.

Methods
In March 2021, we searched for clinical trials on the ClinicalTrials.gov (CT), International Clinical Trials Registry Platform (ICTRP), and International Standard Randomised Controlled Trials Number (ISRCTN) databases. Two authors screened the titles and registry notes of all the searched studies. We collected details of the included studies regarding their design, location funding source, treated conditions, completion, publication statuses, and final outcomes.

Results
We generated a total of 3508 records, and 50 unique clinical trials met our eligibility criteria. Of these, 20 (40%) concerned peripheral artery disease, and 18 (36%) concerned coronary artery disease. Most studies were randomized (34/50, 68%) and were performed in multiple locations (30/50, 60%), and around half of the trials compared GT with a placebo (27/50, 54%), while one in four were single-arm (14/50, 28%), and the rest concerned dose-finding (22%). More than half of the trials (29/50, 58%) were funded by industry. Of the 50 clinical trials, 28 (56%) published their results by the data collection date (March 2021), and 22 of 31 (71%) were slated to be completed before 2021. Overall, 12 of 28 (42.9%) clinical trials showed favorable outcomes of the intervention.

Conclusions
Among noncongenital cardiovascular diseases, GTs are mostly investigated in peripheral artery disease and coronary artery disease. Many clinical trials on GT use in noncongenital cardiovascular diseases did not disclose their results. Regardless of the trial phase, less than half of published studies on GT in noncongenital cardiovascular diseases showed promising results.
A Multimodal Semiotic Discourse Analysis to reveal Sexual Harassment on Direct Message of Social Media
Authors: Lityaningrum Ayu 
Published: March 2022

Adanya pelecehan seksual selama pandemi melalui media sosial perlu perhatian khusus bagaimana pesan tersebut dapat diyakini sebagai pelecehan seksual layaknya pada dunia nyata dengan berbagai ragam gabungan moda seperti tulisan yang disertai dengan emoji. Dengan demikian, penelitian ini bertujuan untuk mendeskripsikan hubungan unsur verbal dan visual dalam membentuk tindakan pelecehan seksual yang dilakukan pelaku dari segi linguistik sehingga dapat dihubungkan dengan Pasal yang dijatuhkan kepada terdakwa apabila kasus dibawa melalui jalur hukum. Metode penelitian ini menggunakan kualitatif dengan teknik pengumpulan data menggunakan studi pustaka. Data yang digunakan adalah bukti pesan dengan indikasi pelecehan seksual terhadap korban yang di dalamnya mengandung unsur verbal dan visual yang berupa emoji. Dalam menganalisis data, peneliti menggunakan teori multimodalitas khususnya makna ideasional dan interpersonal oleh Kress & Leeuwen (2006) dan Halliday & Mathiessen (2004). Penelitian ini terbatas pada ujaran pelaku dan terbatas pada tataran makna Ideasional dan Interpersonal. Hasil yang didapat adalah hubungan kedua moda terlihat dari unsur visual berupa emoji yang dapat memperjelas adanya pelecehan seksual secara verbal melalui media sosial. Hal ini dilihat dari adanya unsur visual yang mengekstensi dan menerangkan unsur verbal. Selain itu, adanya temuan bahwa emoji dapat menjadi alat bukti untuk mengungkap kejahatan melalui bahasa.
Penerapan Metode K-Means pada Data Penduduk Miskin Per Kecamatan Kabupaten Blitar
Authors: Alfiansyah Dede Nor , Nastiti Vinna Rahmayanti Setyaning , Hayatin Nur 
Published: March 2022

Kemiskinan adalah kondisi ketidakmampuan pendapatan seseorang dalam pemenuhan kebutuhan pokok hidup sehingga tidak mampu menjamin kelangsungan hidupnya Kebutuhan hidup meliputi kebutuhan dasar seperti sandang, pangan, tempat tinggal, dan pendidikan. Menurut BPS, yang dikatakan penduduk miskin adalah penduduk yang memiliki rata-rata pengeluaran perkapita perbulan dibawah garis kemiskinan. Kabupaten Blitar adalah salah satu kabupaten di provinsi Jawa Timur. Angka kemiskinan di kabupaten Blitar mengalami penurunan sejak tahun 2016 hingga tahun 2019 dan mengalamai kenaikan di tahun 2020. Langkah untuk mengetahui angka kemiskinan dihitung berdasarkan sampel survei analisis tingkat kemiskinan dalam survey Sosial – Ekonomi Nasional (Susenas) setiap 2 tahun sekali. Pengelompokkan kemiskinan perlu dilakukan setiap tahunnya agar pemerintah dapat mengetahui langkah pencegahan agar kemiskinan tidak meningkat ataupun pemecahan masalah kemiskinan. Pengelompokkan kemiskinan dapat dilakukan dengan menggunakan berbagai metode salah satunya adanya dengan menggunakan metode K-Means. Penggunan metode K-Means ini bertujuan mengelompokkan data per kecamatan kabupaten Blitar yang tergolong penduduk miskin.
Hepatoprotective Effect of Caesalpinia sappan L. Ethanolic Extract on Alloxan Induced Diabetic Rats
Authors: Holidah Diana , Dewi Ika Puspita , Siregar Iskandar P. A. , Aftiningsih Dwi 
Published: March 2022

Background: The complications of Diabetes Mellitus (DM) may lead to other health problems such as heart attack, stroke, kidney failure, leg amputation, vision loss, nerve and liver damage. Increasing free radicals in the hyperglycemic condition in DM can induce inflammation and necrosis that lead to liver damage. This damage causes elevated hepatic enzymes such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Malondialdehyde (MDA) is a biomarker that is often used to evaluate oxidative stress including in vivo experimental models of diabetes. Caesalpinia sappan L. is one of the well-known herbs which has a strong antioxidant effect and has various pharmacology activities, including antidiabetic and hepatoprotective. Objectives: This study is aimed to investigate the effect of Caesalpinia sappan L. ethanolic extract on liver function and antioxidant status in diabetic rats. Material and Methods: Twenty-four diabetic male rats were divided into six groups consisting of the normal control group, negative control, positive control, and Caesalpinia sappan L. extract treatment group at a dose of 50, 100, and 400 mg/kg BW. The diabetic status was induced by alloxan. The animals were given treatment for 14 days, and on the 15th day, their blood and liver were collected to measure the level of AST, ALT, plasma MDA, and liver MDA. Results: The extracts of Caesalpinia sappan L. can decrease the levels of AST and ALP and show a low number of MDA levels both in plasma and liver on diabetic rats induced by alloxan. The dose of 100 mg/kg BW has the best result for lowering AST and ALT levels; meanwhile, the dose of 400 mg/kg BW shows the least value of MDA among all the doses. Conclusions: The Caesalpinia sappan L. ethanolic extract has potential activity as the hepatoprotective and antioxidant in diabetic status.
The Rationality of Antibiotics Use on Acute Diarrhea to Pediatric Inpatients in the Fatmawati Hospital for 2018-2019 Period
Authors: Rokhmah Nisa Najwa , Manuel Yovania Grace Priskila , Putri Kusuma Ema Nillafita , Nurdin Naufal Muharam 
Published: March 2022

Background: Diarrhea is characterized by an increase in the frequency of bowel movements more than three times a day. This disease has a fairly high incidence rate in Indonesia, especially in children. One of the causes of diarrhea is a bacterial infection, therefore it needs to be treated with antibiotics. Several studies show that there are still many antibiotics that are used irrationally. It is necessary to analyze the rationality of the use of antibiotics in pediatric patients with diarrhea using the Gyssens method Objectives: This study is to ascertain the profile of acute diarrhea pediatric patients characteristic and evaluate antibiotics rationality with Gyssens method. Moreover, the purpose of this study is to analyze the factors that influence the rationality of the use of antibiotics in the inpatient pediatric acute diarrhea installation of Fatmawati Hospital 2018-2019 period. Material and Methods: This study is descriptive observational research. The study design was cross-sectional with retrospective data collection which was analysed then qualitatively with the Gyssens flow method Results: The result showed 54,29% antibiotics usde appropriately and rational. The irrational use of antibiotics was 45.7%. The results of statistical analysis with chi-square show a significant relationship between the rationality of antibiotics and the type of antibiotic (ρ = 0.000 < 0.05) and multiple logistic regression analysis showed that the route of drug administration (ρ = 0.000 < 0.05) affected the rationality of antibiotics use. Conclusions: Less than 50% of the patients received irrational treatment according to the Gyssen flow chart and according to the results of statistical analysis, the type of antibiotic and the route of drug administration affected the rationality of antibiotics.
Penguatan Pendidikan Karakter (PPK) Terintegrasi dalam Pembelajaran bagi Guru SD di Desa Ambengan
Authors: Astawan I Gede , Adnyani Ni Kadek Eva Krishna , Asril Nice Maylani , Tirtayani Luh Ayu 
Published: March 2022

Desa Ambengan adalah salah satu desa di Bali yang letaknya di daerah perbukitan memiliki udara yang sangat sejuk serta pemandangan alam yang indah dan alami yang menjadi daya tarik wisatawan asing dan lokal datang menikmati keindahan desa. Dalam bidang pendidikan, di desa Ambengan terdapat 3 sekolah dasar. Penguatan Pendidikan Karakter (PPK) pada sekolah di desa Ambengan hanya diimplementasikan melalui kegiatan nonmengajar. Faktor utama PPK hanya diimplementasikan melalui kegiatan nonmengajar karena guru belum memiliki kesiapan untuk mengintegrasikan PPK dalam pembelajaran. Maka dari itu, pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pemahaman dan melatih guru di SD Negeri di Desa Ambengan tentang pengintegrasian Penguatan Pendidikan Karakter (PPK) dalam pembelajaran. Kegiatan dilaksanakan dengan metode workshop dan pendampingan yang diikuti oleh 20 orang guru SD dan kepala satuan pendidikan di SD Negeri 2 Ambengan. Data dikumpulkan dengan metode angket dan dianalisis secara deskriptif. Hasil kegiatan pengabdian ini menunjukkan bahwa guru mampu memahami dengan baik konsep PPK dan mampu menyusun Rencana Pelaksanaan Pembelajaran (RPP) dengan mengintegrasikan PPK. Harapannya, pelatihan pengintegrasian PPK dalam pembelajaran bagi guru SD dapat dilaksanakan secara berkelanjutan guna menunjang pembelajaran yang bermanfaat.
Prevalência de ponticulus posticus associado aos diferentes biotipos faciais em pacientes que buscam tratamento ortodôntico
Authors: Poletto Cesar Augusto Rodenbusch , Dallabrida Maguidieli , Embaló Bubbacar , Gevaerd Roberta , Ribeiro Andrei Figueiredo , Conte Ana Lurdes 
Published: March 2022

Ponticulus Posticus (PP) significa “pequena ponte posterior” em latim. É definida como uma pequena ponte óssea anormal, que é gerada entre a parte posterior do processo articular superior do osso occipital e a porção posterolateral da margem superior do arco posterior do Atlas. A associação entre PP e algumas anomalias dentárias já foi demonstrada, sendo a impacção palatina de caninos superiores uma delas. Objetivos: o presente estudo avaliou os efeitos das variáveis gênero, idade e padrão vertical, comparado na frequência e tipo de PP (forma parcial ou completa) em uma amostra retrospectiva transversal de radiografias cefalométricas laterais de pacientes saudáveis, ortodonticamente não tratados. Materiais e métodos: a amostra incluiu radiografias laterais de 300 pacientes (n = 300) - (124 homens e 176 mulheres) de uma clínica odontológica da cidade de Lages/SC. A presença de Ponticulus Posticus (parcial ou completa) foi avaliada, levando-se em consideração gênero, idade e padrão vertical.	Após	análise	descritiva	dos	dados,	os	mesmos	foram	submetidos	ao	teste	chi	quadrado	(�	= 0,05). Resultados: a prevalência geral de Ponticulus Posticus foi de 11% (30 de 300) com as formas parcial e completa verificadas, respectivamente, em 6,3% (19 de 300) e 4,7% (11 de 300) da amostra. Não foram encontradas associações com gênero (p = 0,611) e idade (p = 0,761). O padrão vertical teve relevância significativa com a presença de PP (p = 0,007). Conclusão: há uma associação positiva entre o padrão vertical do tipo braquifacial com uma maior prevalência de Ponticulus Posticus em suas formas parcial e completa.
PENGEMBANGAN MODEL PEMBELAJARAN JELAJAH ALAM SEKITAR (JAS) PADA MATERI KEANEKARAGAMAN HAYATI SEBAGAI SUMBER BELAJAR KELAS X DI SMAN 1 CUKUH BALAK
Authors: Yani Aprida , Widowati Hening , Achyani Achyani 
Published: March 2022

Tujuan penelitian: (1) menghasilkan produk model pembelajaran Keanekargaman Hayati berbasis Ekosistem Mangrove sebagai Sumber Belajar Kelas X di SMAN 1 Cukuh Balak, (2) mengetahui tingkat kepraktisan model pembelajaran Keanekargaman Hayati berbasis Ekosistem Mangrove dan (3) mengetahui tingkat keefektifan model pembelajaran Keanekargaman Hayati berbasis Ekosistem Mangrove. Research and development adalah Penelitian yang digunakan dalam mengembangkan model pembelajaran Keanekargaman Hayati berbasis Ekosistem Mangrove sebagai Sumber Belajar Kelas X di SMAN 1 Cukuh Balak tahun pelajaran 2021/2022. Hutan mangrove di pantai Kecamatan Cukuh Balak mempunyai arti yang sangat penting baik sebagai suatu ekosistem maupun sebagai sumber daya alam. Keberadaan hutan mangrove di Cukuh Balak ini mulai mengalami perubahan disebabkan karena adanya Campur tangan manusia yang semakin meningkat terhadap hutan mangrove dalam rangka memenuhi kebutuhan atau meningkatkan kualitas hidupnya, Hutan Mangrove bisa digunakan sebagaih bahan belajar siswa SMAN 1 Cukuh Balak Kelas X pada materi Keanekaragaman Hayati.
Protein Nabati Daun Singkong Untuk Pertumbuhan Kelinci Lokal
Authors: Putri Nirwana Elsa , Sujarwanta Agus , Santoso Handoko 
Published: March 2022

Studi ini bertujuan untuk mengetahui kandungan protein nabati dari daun singkong dan juga pengaruhnya terhadap pertumbuhan kelinci. Potensi sebagai hewan ternak pedaging dan juga hias menjadi suatu daya pikat bagi masyarakat untuk memilihara kelinci. Hal ini juga didukung dengan produktifitas kelinci yang baik dan memiliki gizi yang tinggi untuk di kosumsi. Pakan adalah faktor penting yang mempengaruhi pertumbuhan kelinci. Sumber pakan yang dapat dimanfaatkan untuk kelinci salah satunya daun singkong karena mengandung nilai nutrisi yang cukup tinggi dan sangat berpengaruh terhadap pertumbuhan kelinci. Kandungan gizi yang terdapat pada daun singkong meliputi BK 25,30%, PK 25,10%, LK 12,70%, SK 11,40%, BETN 46,10%, Ca 1,10-1,40%, dan P 0,25-0,30% sedangkan Kandungan asam amino arginin 5,9%; histidin 1,9%; isoleusin 4,4%; leusin 8,0%; lysin 5,6%; metionin 1,5%; penilalanin 5,7%; treonin 4,0%; tirosin 4,0%; valin 5,3%.
Мои археологические университеты
Authors: Кокорина Нина Александровна 
Published: March 2022

Автор вспоминает о своем пути в археологию. Начало его связано с кружком археологов при Государственном музее Татарской АССР и его руководителем Е.А. Халиковой. Дальнейшие шаги вхождения в науку проходили в студенческом археологическом кружке Казанского университета и в коллективе археологов Института языка, литературы и истории им. Г. Ибрагимова Казанского филиала АН СССР. В статье отмечается роль первых экспедиций в выборе профессии, а затем и научной проблематики, рассказывается о деятельности кружка археологов Государственного музея Татарской Республики и студенческого археологического кружка Казанского университета в 1960–1970-е годы. Ключевая роль в деятельности этих кружков принадлежала казанским археологам 1960–1970-х гг. – Е.А. Халиковой и А.Х. Халикову, а также археологам ИЯЛИ КФАН СССР – Т.А. Хлебниковой, П.Н. Старостину, Е.П. Казакову, Р.С. Габяшеву и др.
Антропологические материалы из «Культового Кургана» (Азербайджанская Республика)
Authors: Кириченко Дмитрий Александрович 
Published: March 2022

В статье представлены краниологические материалы из так называемого «Культового кургана» или же кургана № 36 из раскопок (полевой сезон 1937 г.) азербайджанского археолога Я.И. Гуммеля. Курган был расположен в долине р. Гянджачай, к западу от г. Гёйгёль (Азербайджанская Республика). Здесь были выявлены погребения эпохи ранней бронзы (куро-араксская археологическая культура), поздней бронзы-раннего железа (Ходжалы-Кедабекская археологическая культура) и средневековья. Исследованный нами палеоантропологический материал относится к периоду поздней бронзы-раннего железа (Ходжалы-Кедабекская археологическая культура) и датируется концом II – началом I тыс. до н.э. Всего было изучено четыре черепа: три мужских (№ 1–3) и один женский (№ 4). Вероятно, мужские и женский черепа из «Культового кургана» принадлежали представителям южной ветви европеоидной расы и относились к ее брахикранному варианту, распространенному в Гянджа-Газахском регионе Азербайджана еще с эпохи ранней бронзы. Результаты исследования позволяют сделать вывод, что люди, захороненные в жальнике кургана, являлись автохтонами этой зоны Азербайджана, данному утверждения не противоречат и археологические материалы, обнаруженные возле погребенных. Отмечается определенная преемственность населения на территории Гянджа-Газахского региона Азербайджана от эпохи ранней – поздней бронзы – раннего железа – средневековья и вплоть до современного периода.
Das Selbst in der Krise – Krise des Selbst
Authors: Hell Daniel 
Published: March 2022

Das «Selbst» ist ein moderner Begriff. In den Wissenschaften hat er sich parallel zur Individualisierung der Gesellschaft durchgesetzt und die traditionelle Seele verdrängt. Er basiert auf der menschlichen Fähigkeit, sich ein Bild von sich selber zu machen und sich selbst zu behaupten. Wo er hauptsächlich als kognitiver oder reflexiver Selbstbezug verstanden wird, findet seine Anwendung in der psychiatrisch - psychotherapeutischen Behandlung rasch ihre Grenzen. Viele psychisch kranke Menschen sind affektiv herabgestimmt oder spüren sich weniger; sie erleben sich mithin präreflexiv – in leib-seelischer Hinsicht – verändert. Davon sind auch Identitäts- und Vertrauensbildung betroffen. Eine Krise des «Selbst» ist keine nur reflexive Problematik. Das präreflexive Selbstbewusstsein einzubeziehen erfordert ein erweitertes Selbstverständnis. Dazu werden sowohl in grundsätzlicher wie praktischer Hinsicht Vorschläge gemacht.
Recent Development-1 of CADTEL Software: The Resolution and Focusing Parameters Affecting at the Properties of Electron Magnetic Lenses
Authors: Hasan Hussain S. , Obaid Sura Allawi , Erhayief Muhssen Salbookh 
Published: March 2022

Computer Aided Designing Tools of Electron Lenses (CADTEL) is a software packages cares about design, compute and plot simultaneously of the objective and projector properties of electron magnetic lenses. The developments in CADTEL software leads to contain a large fields and methods, adding to previous publish in 2013. The current improvement is inserting of some important parameters which are the resolution and focusing parameters. These parameters are angular semi-angle (α), focusing power (β), resolution limit (δ), image rotation (θ), spherical aberration (Cs), defocus (ΔZ), wave aberration (Χwab), depth of field (Dfld), and depth of focus (Dfoc) at certain magnification conditions. Thus, user can easily compute and plot, according to relations and forms, the effect of these parameters at the lens properties of four magnification conditions; zero, infinite and finite (low and high) magnification modes. This work introduces a new development for CADTEL software which is an interactive visual interface in electromagnetic lenses.Whereas, it reflects a substantial reduction of time and resources desired for training new users and researchers in electron optics field. The results and curves representations appear with visual interfaces which are coded in visual basic programing language. In addition, the computations and figures which were plotted appeared that complete identification between these results which are obtained from CADTEL and that from other software’s and direct computations methods.
Estimating the Reliability Function for Transmuted Pareto Distribution Using Simulation
Authors: Hasan Masa Mohammed , Salih Makki A. Mohammed 
Published: March 2022

In this work, the methods (Moments, Modified Moments, L-Moments, Percentile, Rank Set sampling and Maximum Likelihood) were used to estimate the reliability function and the two parameters of the Transmuted Pareto (TP) distribution. We use simulation to generate the required data from three cases this indicates sample size , and it replicates for the real value for parameters, for reliability times values we take .
Results were compared by using mean square error (MSE), the result appears as follows :
The best methods are Modified Moments, Maximum likelihood and L-Moments in first case, second case and third case respectively.
Preliminary studies on predatory potential of Australian ladybird beetle, Cryptolaemus montrouzieri Mulsant against Mealybug, Planococcus lilacinus Cockerell
Authors: Karthikeyan A. , Lavanya G. , Naveena K. , Mangayarkarasi P. 
Published: March 2022

Mealybug Planococcus lilacinus Cockerell (Hemiptera: Pseudococcidae) damages Cocoa, Guava, Citrus, Cotton and other plant families. Besides causing direct loss to the plants they also reduce the market value of infested fruits. The extent of the damage may go up to 70 percent in a severe infestation. An Australian ladybird beetle, Cryptolaemus montrouzieri Mulsant (Coleoptera: Coccinellidae) introduced from Australia is a potential bio-control agent and is being utilized on many crops in Southern India. Mealybugs or scale insects constitute the natural food of certain ladybird beetles. The adult beetles as well as their larvae (grubs) seek the pests and feed voraciously on all stages. They often wipe out the entire pest colonies. The ladybird beetles are being used for suppression of mealy bugs in citrus, coffee, grapes, guava, ornamental and a variety of other crops. The feeding potential of different development stages of C. montrouzieri, a biological control agent against mealybugs, was investigated on P. lilacinus. Fourth instar grubs and adults of C. montrouzieri were the most voracious feeders of mealybug. The number of mealybug consumed by 1st, 2nd, 3rd and 4th instar larvae and adult beetles of C. montrouzieri was 20, 33.30, 37.50, 40 and 66.60 percent respectively. The results indicate that C. montrouzieri has the potential to be exploited as a bio-control agent. Inoculative releases of 4th instar larvae and adults may provide instant control of P. lilacinus. Field experiments should be conducted to determine the efficiency of the ladybird beetle on this mealybug.
On Inductive Limit of Commutative Triples
Authors: Timite Lamine , Toure Ibrahima 
Published: March 2022

In this paper, we extend Olshanski's work on Gelfand pairsÂ to commutative triples. We introduce the notion of spherical triples as generalization of commutative triples. We prove that inductive limit ofÂ increasing sequence of commutative triples is a spherical triple which shows that the former is also a generalization of spherical pairs. Furthermore we define spherical functions associated with this spherical triples. At end, we characterize this spherical functions by a functionnal equation and we give some of its properties.