bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research knowledge transfer to improve the care and support of adolescents with sickle cell disease in Ghana
Authors: Poku Brenda A. , Pilnick Alison 
Published: August 2022

AbstractIntroductionEffective transfer of research findings to key knowledge users, particularly in low‐ and middle‐income countries, is not always achieved, despite being a shared priority among researchers, funders, healthcare and community stakeholders and decision‐makers. A constructivist grounded theory study conducted in 2015–2019 in Ghana that explored sickle cell‐related fatigue in adolescence resulted in numerous implications for practice and policy. Peer‐reviewed funding was obtained to support disseminating these findings to relevant stakeholders.MethodsKey steps in implementing this study dissemination project included: (1) identifying and attracting target stakeholders from healthcare and community organizations; (2) tailoring tools for communication of research findings for the stakeholder groups and (3) designing interactive workshops to facilitate knowledge sharing and uptake.FindingDespite the COVID‐19 pandemic, 50 healthcare and community stakeholders participated in the dissemination workshops. The dissemination activities contributed new layers of understanding to the original research findings through discussions. Through the workshops, participants identified culturally valuable and actionable recommendations that they could take forward to improve care and support for young people with sickle cell disease in Ghana. A follow‐up 6 months post the workshops indicated some positive knowledge usage and benefits.ConclusionThis dissemination project provided a unique opportunity for researchers and stakeholders to share in the interpretation of research findings and to strategically plan recommendations to improve SCD‐focused care and support for young people in Ghana. Further research dissemination should continue to be grounded in locally generated knowledge, include systematic, long‐term evaluation of dissemination outcomes and be adequately financed.Patient and Public ContributionPublic involvement in this study was critical to the research dissemination project. The Sickle Cell Association of Ghana (Kumasi chapter) actively supported the project's development, organization and facilitation. Parent members of the Association, the Association's executive members and volunteers, and the health professionals involved in sickle cell care at the Komfo Anokye Teaching Hospital participated in the project workshops. They contributed to the knowledge transfer and uptake.
Multifunctional risk in the adoption of innovative technological products
Authors: Scatulino Patrícia Leite da Silva , Arruda Filho Emílio José Montero 
Published: August 2022

AbstractThis study analyses whether the perceived risk of purchasing technological products is less influential on the process of technological adoption when this effect is moderated by the product's multifunctional category (hedonic vs. utilitarian product characteristics). Four experiments were developed according to scenarios related to the multifunctional content (level of complexity according to the product category) of the technology and the number of functionalities in the products. The perception of risk has less effect on adoption when the product characteristics are manipulated to be more utilitarian or heighten the consumer's social value. This study contributes to the theoretical understanding of which categories are less influenced by the perceived multifunctional risk of purchasing and adopting a new technology, as well as of when individual values overlap with consumers' risk perceptions. It also contributes managerially by identifying the profile of individuals who are more likely to consume innovations characterized by high complexity and functionality, and by providing guidance for the development of innovative products that prioritize utilitarian, rather than hedonic, characteristics.
Anticipation in leisure—Effects on labor‐leisure choice
Authors: Chatterjee Bibaswan , Escobar‐Posada Rolando , Monteiro Goncalo 
Published: August 2022

AbstractThis paper introduces the idea of a forward‐looking reference benchmark on both consumption and leisure in the context of a Ramsey–Cass–Koopmans growth model by assuming that in addition to consumption and leisure the household utility also depends on reference benchmarks of future anticipated consumption and leisure. We analyze the macrodynamic equilibrium, contrasting it to the case when the reference benchmarks are backward‐looking. We investigate if the presence of anticipation in leisure can lead to smoother jumps in labor under productivity shocks and what effect that has on the consumption adjustment at the time of shock. We present our results using numerical simulations that confirm the existence of parameter spaces where a dual anticipation model leads to smaller jumps in labor, albeit sometimes at the expense of higher consumption jumps.
Correlation of exit sites of inducible ventricular tachycardia post‐ST elevation myocardial infarction on electrophysiology study, with region of infarct
Authors: Rao Karan , Danaila Vlad , Bennett Richard G. , Turnbull Samual , Campbell Timothy , Kumar Saurabh 
Published: August 2022

AbstractBackgroundVentricular arrhythmia (VA) is the most common cause of sudden cardiac death post‐ST elevation myocardial infarction (STEMI). Ventricular tachycardia (VT) may be inducible in electrophysiology studies (EPS) early (<40 days) post‐STEMI. Whether it originates from the infarct site remains unknown. We examined the correlation between inducible VT and infarct location post‐STEMI.AimsTo investigate the correlation between inducible VT and infarct location post‐STEMI.MethodsWe retrospectively analysed 46 patients from 2005 to 2017 with STEMI who underwent early programmed ventricular stimulation through EPS (>48 h post‐STEMI and <40 days from admission). Gated heart pool scans were used to visualise infarct scar regions, and VT exit sites were derived from induction 12‐lead electrocardiography. Patients were followed up for primary outcomes of recurrent VA and all‐cause mortality.ResultsForty‐six patients were included for analysis, with 50 uniquely induced VT exit sites. Mean left ventricular ejection fraction was 30 ± 8.7% and 22% had impaired right ventricular ejection fraction. Mean time from presentation to EPS was 16 ± 31.3 days. Of the induced VT, 44 (88%) were from within scar and scar‐border regions, whereas 6 (12%) of the induced VT were found to be remote to imaging‐derived scar. Over a median follow‐up period of 75 months, 6 (13%) patients died, and 7 (15%) patients had recurrent VA. No deaths occurred in patients with remote VT.ConclusionThe majority of early inducible post‐infarct VT arises from acute myocardial scar; however, a small portion arises from sites remote from scars with a possible focal aetiology.
A systematic review of the perceptions and attitudes of mental health nurses towards alcohol and other drug use in mental health clients
Authors: Merrick Tammy Tran , Louie Eva , Cleary Michelle , Molloy Luke , Baillie Andrew , Haber Paul , Morley Kirsten C. 
Published: August 2022

AbstractMental and substance use disorders are leading contributing factors for the Australian non‐fatal burden of disease. These disorders frequently co‐occur in the mental health population, and mental health nurses are the largest group of professionals treating dual diagnosis. A comprehensive understanding of mental health nurses' attitudes and perceptions is required to inform future implementation of dual diagnosis training programs. A systematic literature review of sources derived from electronic databases including Medline, CINAHL, SCOPUS review, and PsychINFO, along with Connected Papers. Selection criteria included a focus on mental health nurses' attitudes towards dual diagnosis of mental illness and substance use. Extracted data was qualitatively synthesized. Of the 5232 articles retrieved initially, 12 were included in the review. Four themes emerged from the synthesis: drug and alcohol use among mental health consumers (seven studies), caring for dual diagnosis consumers (eight studies), role perception (six studies), and treatment optimism (five studies). Salient beliefs included substance use as a self‐inflicted choice (71%) or a form of ‘self‐medication’ (29%); a lack of willingness to provide care (75%), or a strong commitment to care (25%); greater comfort with screening and acute medical management rather than ongoing management (83%); and pessimism about treatment effectiveness (100%). Mental health nurses' beliefs and attitudes towards dual diagnosis were often negative, which is likely to result in poor quality care and treatment outcomes. However, the lack of recent studies in this research area indicates the need for up‐to‐date knowledge that can inform the development of training programs.
Improving the properties of fish skin collagen/silk fibroin dressing by chemical treatment for corneal wound healing
Authors: Pourjabbar Bahareh , Biazar Esmaeil , Heidari Keshel Saeed , Baradaran‐Rafii Alireza 
Published: August 2022

AbstractNatural biomaterials are crucial in ocular tissue engineering because they allow cells to proliferate, differentiate, and stratify while maintaining the typical epithelial phenotype. In this study, membranes as dressings were formed from silk fibroin and collagen (Co) extracted from fish skin and then modified with carbodiimide chemical cross linker in different concentrations. The samples were evaluated by different analyses such as structural, physical (optical, swelling, denaturation temperature, degradation), mechanical, and biological (viability, cell adhesion, immunocytochemistry) assays. The results showed that all membranes have excellent transparency, especially with higher silk fibroin content. Increasing the cross linker concentration and the ratio of silk fibroin to Co increased the denaturation temperature and mechanical strength and, conversely, reduced the degradation rate and cell adhesion. The samples did not show a significant difference in toxicity with increasing cross linker and silk fibroin ratio. In general, samples with a low silk fibroin ratio combined with cross linker can provide desirable properties as a membrane for corneal wound healing.
Particular body odors matter: Disgust sensitivity differs across attachment groups
Authors: Shell Amy , Blomkvist Anna , Mahmut Mehmet K. 
Published: August 2022

AbstractExtensive research has highlighted how one's attachment style influences the development and maintenance of romantic relationships. Disgust is a construct that conceptually overlaps with attachment style given both include elements of behavioral avoidance. However, no previous study has examined how one's attachment style may influence disgust‐based avoidance of intimacy in romantic relationships. Therefore, the aim of the current study is to determine if adult attachment style is associated with olfactory disgust ratings towards eight body odor (BO) sources from their partner, previous partner, or others. The results revealed that disgust ratings of a partner's BO differed depending on attachment style. Specifically, the participants with a dismissing‐avoidant attachment style rated their partner's BO as more disgusting than the secure, fearful‐avoidant, or preoccupied styles. Moreover, participants with a dismissing‐avoidant attachment style rated their partner's and strangers' BO equally disgusting whereas those in the other attachment groups rated strangers' BO as more disgusting than their partner's.
Methodology for energy demand reduction of potato cold storage process
Authors: Sáenz‐Baños Mercedes , Latorre‐Biel Juan Ignacio , Martínez‐Cámara Eduardo , Jiménez‐Macías Emilio , Longo Francesco , Blanco‐Fernández Julio 
Published: August 2022

AbstractIn order to maintain the quality of the potatoes over time, it is necessary to store them under certain storage conditions, which minimize losses both of quality and product, preferably without using chemical treatments. Conservation chambers consume a considerable amount of energy. Between 60% and 70% of the electricity consumed is used in refrigeration. Good insulation reduces the need for cooling the potato since its optimum storage temperature for consumption is around 4–7°C and relative humidity is 85%–90%. This research studies potatoes’ cold storage process to minimize the cost in the product value chain and to ensure its competitiveness in the market. A model is developed to assess energy consumption and propose measures to reduce energy, environmental, and economic costs. All this to reduce their impact within the value chain of potato consumption.Practical ApplicationsIn this case study, different energy efficiency measures applied to the cold storage of potatoes have been implemented: replacement or improvement of the performance of refrigeration equipment, insulation and infiltrations in the refrigeration chamber, control of the product entry temperature, thermal conditioning through free‐cooling, improvements in lighting equipment, technical management, and supervision of facilities, and thermographic control. The set of actions implemented has allowed to obtain a reduction in energy demand, standardized through the developed reference line, by 16.41% compared to previous years.
Carbon footprinting for hospital care pathways based on routine diagnosis‐related group (DRG) accounting data in Germany: An application to acute decompensated heart failure
Authors: Zhang Xiange , Albrecht Klaus , Herget‐Rosenthal Stefan , Rogowski Wolf H. 
Published: August 2022

AbstractA general framework is developed using routine German diagnosis‐related group (G‐DRG) accounting data to estimate carbon footprints of hospital care pathways in the context of patients with acute decompensated heart failure (ADHF) admitted to the Red Cross Hospital Bremen in 2018. Financial activity data encompass G‐DRG material costs from hospital accounting data submitted to the Institute for the Hospital Remuneration System. A set of seven greenhouse gases (GHGs) is included. Environmentally extended input–output emission factors (EFs) compiled by Eurostat are employed. EFs of cost modules are calculated separately considering respective emissions' intensities. Total emissions reach 72,652 kg carbon dioxide equivalent (CO2e) (nonbiogenic: 85.5%; biogenic: 14.5%) for general inpatient care throughout ADHF patient care pathways in 2018. Emissions from normal wards account for the largest proportion (74.8%) of total emissions for ADHF patients. Compared to other matched industry categories, cost‐types covered by the industry category D “electricity, steam and air conditioning supply” cause the vast majority (approximately 87%) of total emissions. GHG emissions per unit of analysis, per bed day, and per euro are estimated at 263, 32, and 0.31 kg CO2e, respectively. Although this framework is currently limited to hospitals that participate in the G‐DRG calculation scheme or apply these accounting standards on a voluntary basis, it has particular advantages that render it amenable to other contexts. It enables the calculation of emissions separately for each cost module considering its specific emission intensity, which can improve the accuracy of estimates.
Spatial and temporal specificity of neuroestradiol provision in the songbird
Authors: Saldanha Colin J. 
Published: August 2022

AbstractSteroid hormones are often synthesized in multiple tissues, affect several different targets, and modulate numerous physiological endpoints. The mechanisms by which this modulation is achieved with temporal and spatial specificity remain unclear. 17β‐estradiol for example, is made in several peripheral tissues and in the brain, where it affects a diverse set of behaviors. How is estradiol delivered to the right target, at the right time, and at the right concentration? In the last two decades, we have learned that aromatase (estrogen‐synthase) can be induced in astrocytes following damage to the brain and is expressed at central synapses. Both mechanisms of estrogen provision confer spatial and temporal specificity on a lipophilic neurohormone with potential access to all cells and tissues. In this review, I trace the progress in our understanding of astrocytic and synaptic aromatization. I discuss the incidence, regulation, and functions of neuroestradiol provision by aromatization, first in astrocytes and then at synapses. Finally, I focus on a relatively novel hypothesis about the role of neuroestradiol in the orchestration of species‐specific behaviors.
Morbidly obese pregnant woman with congenital leptin deficiency: Follow‐up and obstetric outcome
Authors: Cagliyan Erkan , Ozmen Samican , Timur Hikmet T. , Ozgozen Mehmet E. , Semiz Gokcen G. 
Published: August 2022

AbstractCongenital leptin deficiency is a rare congenital genetic disease. It is characterized by early‐onset, severe morbid obesity. The disease occurs due to mutations in the LEP gene. Obesity is a severe consequence of the disease. It also causes reproductive and obstetric complications. In this study, we present a 26‐year‐old pregnant case who had been previously diagnosed with congenital leptin deficiency. The pregnancy made it more difficult to regulate the metabolic changes caused by the disease. Problems were held by a multidisciplinary approach, with the contribution of endocrinology and cardiology departments. The patient gave birth to a healthy girl at the 37th week of gestation. Spontaneous pregnancy resulting in a live birth is very uncommon in women with congenital leptin deficiency. The follow‐up and treatment approaches during pregnancy and the obstetric outcome are presented with the literature.
A clinical model and nomogram for early prediction of gestational diabetes based on common maternal demographics and routine clinical parameters
Authors: Zhang Di , Zhang Sujuan , Li Guoyi , Lai Yingsi , Hao Yuan‐tao , Chen Wei‐qing , Wu Yi , Chen Chaogang , Pan Wenjing , Liu Zhao‐min 
Published: August 2022

AbstractAimWe aimed to develop a risk prediction model for gestational diabetes mellitus (GDM) based on the common maternal demographics and routine clinical variables in Chinese population.MethodsIndividual information was collected from December 2018 to October 2019 by a pretested questionnaire on demographics, medical and family history, and lifestyle factors. Multivariable logistic regression was performed to establish a predictive model for GDM by variables in pre‐ and early pregnancy. The consistency and discriminative validity of the model were evaluated by Hosmer‐Lemeshow goodness‐of‐fit testing and ROC curve analysis. Internal validation was appraised by fivefold cross‐validation. Clinical utility was assessed by decision curve analysis.ResultsTotal 3263 pregnant women were included with 17.2% prevalence of GDM. The model equation was: LogitP = −11.432 + 0.065 × maternal age (years) + 0.061 × pre‐pregnancy BMI (kg/m2) + 0.055 × weight gain in early pregnancy (kg) + 0.872 × history of GDM + 0.336 × first‐degree family history of diabetes +0.213 × sex hormone usages during pre‐ or early pregnancy + 1.089 × fasting glucose (mmol/L) + 0.409 × triglycerides (mmol/L) + 0.082 × white blood cell count (109/L) + 0.669 × positive urinary glucose. Homer‐Lemeshow goodness‐of‐fit testing indicated a good consistency between predictive and actual data (p = 0.586). The area under the ROC curve (AUC) was 0.720 (95% CI: 0.697 ~ 0.744). Cross‐validation suggested a good internal validity of the model. A nomogram has been made to establish an easy to use scoring system for clinical practice.ConclusionsThe predictive model of GDM exhibited well acceptable predictive ability, discriminative performance, and clinical utilities. The project was registered in clinicaltrial.gov.com with identifier of NCT03922087.
Trends and disparities in breastfeeding initiation in France between 2010 and 2016: Results from the French National Perinatal Surveys
Authors: Guajardo‐Villar Andrea , Demiguel Virginie , Smaïli Sabira , Boudet‐Berquier Julie , Pilkington Hugo , Blondel Beatrice , Salanave Benoit , Regnault Nolwenn , Pelat Camille 
Published: August 2022

AbstractBreastfeeding (BF) initiation rates in French maternity units are among the lowest in Europe. After increasing for several years, they decreased between 2010 and 2016, although several maternal characteristics known to be positively associated with BF in France were more frequent. We aimed to (1) quantify adjusted trends in BF initiation rates between 2010 and 2016; (2) examine associations between BF initiation rates and newborn, maternal, maternity unit, and department‐level characteristics. Using data from the 2010 (n = 12,224) and 2016 (n = 11,089) French National Perinatal Surveys, we analysed BF initiation (exclusive, mixed, and any) through a succession of six mixed‐effect multinomial regression models, progressively adding adjustment covariates. Adjusted exclusive and any BF initiation rates decreased by 9.6 and 4.5 points, respectively, versus by 7.7 and 1.8 points, respectively, in the crude analysis. In both years, adjusted exclusive and any BF initiation rates were lowest in the following categories of mothers: low education level, single, high body mass index and multiple or premature births. Exclusive BF initiation decreased most in primiparous mothers, those with the lowest household income, mothers that had a vaginal delivery, women born in an African country and those who delivered in a maternity unit without Baby‐Friendly Hospital Initiative designation. The 2010–2016 decrease in BF initiation rates in France cannot be explained by changes in mothers' characteristics; quite the opposite, adjustment increased its magnitude. Additional efforts should be put in place to understand why this decrease is particularly sharp in some subgroups of mothers.
Positive selection and heat‐response transcriptomes reveal adaptive features of the Brassicaceae desert model, Anastatica hierochuntica
Authors: Eshel Gil , Duppen Nick , Wang Guannan , Oh Dong‐Ha , Kazachkova Yana , Herzyk Pawel , Amtmann Anna , Gordon Michal , Chalifa‐Caspi Vered , Oscar Michelle Arland , Bar‐David Shirli , Marshall‐Colon Amy , Dassanayake Maheshi , Barak Simon 
Published: August 2022

Summary

Plant adaptation to a desert environment and its endemic heat stress is poorly understood at the molecular level. The naturally heat‐tolerant Brassicaceae species Anastatica hierochuntica is an ideal extremophyte model to identify genetic adaptations that have evolved to allow plants to tolerate heat stress and thrive in deserts.

We generated an A. hierochuntica reference transcriptome and identified extremophyte adaptations by comparing Arabidopsis thaliana and A. hierochuntica transcriptome responses to heat, and detecting positively selected genes in A. hierochuntica.

The two species exhibit similar transcriptome adjustment in response to heat and the A. hierochuntica transcriptome does not exist in a constitutive heat ‘stress‐ready’ state. Furthermore, the A. hierochuntica global transcriptome as well as heat‐responsive orthologs, display a lower basal and higher heat‐induced expression than in A. thaliana. Genes positively selected in multiple extremophytes are associated with stomatal opening, nutrient acquisition, and UV‐B induced DNA repair while those unique to A. hierochuntica are consistent with its photoperiod‐insensitive, early‐flowering phenotype.

We suggest that evolution of a flexible transcriptome confers the ability to quickly react to extreme diurnal temperature fluctuations characteristic of a desert environment while positive selection of genes involved in stress tolerance and early flowering could facilitate an opportunistic desert lifestyle.