bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disruption and recovery of river planktonic community during and after the COVID-19 outbreak in Wuhan, China
Authors: Chen Junwen , Qi Weixiao , Wang Donglin , Wang Qiaojuan , Lin Hui , Mao Guannan , Liang Jinsong , Ning Xue , Bai Yaohui , Liu Huijuan , Qu Jiuhui 
Published: September 2022

Abstract
During the COVID-19 outbreak in Wuhan, large amounts of anti-coronavirus chemicals, such as antiviral drugs and disinfectants were discharged into the surrounding aquatic ecosystem, causing potential ecological damage. Here, we investigated plankton in the Wuhan reaches of the Yangtze River, before, during, and after COVID-19, with the river reaches of three adjacent cities sampled for comparison. During the COVID-19, planktonic microbial density declined significantly. Correspondingly, the eukaryotic and prokaryotic community compositions and functions shifted markedly, with increasing abundance of chlorine-resistant organisms. Abundance of antibiotic resistance genes, virulence factor genes, and bacteria containing both genes increased by 2.3-, 2.7-, and 7.9-fold, respectively, compared to other periods. After COVID-19, all measured plankton community compositional and functional traits recovered in the Yangtze River.
Intentional controlled islanding based on dynamic community detection for power grid
Authors: Han Xu , Huangpeng Qizi , Duan Xiaojun , Gao Qiannan , Yin Yimin 
Published: September 2022

AbstractPower system controlled islanding is an emergency control method used to stop the propagation of disturbances and avoid blackouts. Intentional controlled islanding (ICI) has been proposed as a corrective measure of last resort to split the power system into several sustainable islands. Complex network community detection is widely used in network partitioning and can be used to solve controlled islanding problems. The objective of this study is to apply the dynamic network community detection method to solve ICI problems. Using dynamic network modelling, the division‐agglomeration (Di‐Ag) algorithm is proposed. Dynamic modelling presets the computation task of the algorithm in the healthy grid phase. The algorithm balances the efficiency of the algorithm, power imbalance, and power flow disruption, without sacrificing other objectives to optimise one objective. Specifically, the grid topology is taken into account when the grid is divided using betweenness as edge weight. The first step of the Di‐Ag algorithm uses the dynamic Girvan–Newman algorithm to achieve the goal of power imbalance. Moreover, only the islands' involved lines (nodes) are updated, which improves the efficiency of the algorithm. In the second step of the Di‐Ag algorithm, the algorithm merges the islands to reduce power flow disruption. The IEEE 39‐bus and 118‐bus system are used to compare the performance of the proposed dynamic modelling method and the static network community discovery method in three different cases.
Optimization scheme of partial discharge location of external insulation based on 2‐D multiple signal classification algorithm
Authors: Pei Shaotong , Liu Dewang , Ye Zijian , Yang Jiajun , Liu Yunpeng 
Published: September 2022

AbstractPartial discharge (PD) localization is critical to ensure the safe operation of power equipment. In this paper, an optimization scheme is developed for PD positioning of external insulation equipment. The optimization scheme is based on an eight‐element cross sensor array to receive the ultrasonic signal generated by the PD, and uses the highly accurate 2‐D multiple signal classification (2‐D MUSIC) algorithm to locate the signal. Simulated discharge signal is adopted to test the optimization scheme, and the results show that the positioning error is less than 0.61° when the signal‐to‐noise ratio (SNR) is above −5 dB. In addition, three discharge models are tested at various locations. The average azimuth errors are 0.9°, 1.9°, and 1.55° for the needle‐plate, cone‐plate, and ball‐plate discharge models, respectively, and the average pitch angle errors are 0.75°, 2.1°, and 1.4°, respectively. These show that the needle‐plate model has the best positioning effect. Simulations and experiments are also carried out on the double discharge source scenario, and the error is within 2.2°. A PD location visualization equipment based on the proposed optimization scheme is developed and applied on‐site. The equipment is capable of satisfying the requirements of operation and maintenance.
The 50 Most Cited Publications on Concentrated Bone Marrow Aspirate with Application in Orthopaedic Surgery
Authors: Oeding Jacob F. , Hernandez Hunter C. , Bi Andrew S. , Kennedy John G. , Jazrawi Laith M. , Strauss Eric J. , Campbell Kirk A. 
Published: September 2022

AbstractConcentrated bone marrow aspirate (cBMA) has garnered widespread and increasing attention in recent years. We aimed to characterize the most influential articles in cBMA research while clarifying controversies surrounding its use and clinical efficacy and identifying important areas on which to focus future research efforts. The Science Citation Index Expanded subsection of the Web of Science Core Collection was systematically searched to identify the top 50 most cited publications on orthopaedic cBMA research. Publication and study characteristics were extracted, and Spearman's correlations were calculated to assess the relationship between citation data and level of evidence. The top 50 articles were published between the years 1996 and 2018, with 58% published in the year 2010 or later. Of the 29 studies for which level of evidence was assessed, the majority were Level IV (24, 83%). Twenty-one articles (42%) were classified as basic science or translational (9 cell culture, 8 animal study, and 4 using human blood samples). Application to treat cartilage defects was the most common focus of studies (17 studies, 34%), followed by analysis of cBMA composition (14 studies, 28%). No correlation was found between rank, citation rate, or year of publication and level of evidence. The most influential articles on cBMA are recent and consist of a majority low level of evidence studies. Cohort studies were the most common study type among the top 50 most cited articles, while basic science articles were relatively less common. These results suggest a rapidly evolving field with the potential to better explain inconsistent clinical results with improved understanding and documentation of basic science concepts in addition to large-scale, prospective clinical trials. Orthobiologics especially cBMA holds great promise for the future, and higher level clinical trials will help better define the best clinical uses for this treatment.
Leveraging and Improving Refill Protocols at Your Health System
Authors: Tokazewski Jeffrey T. , Peifer Maryanne , Howell John T. 
Published: September 2022

Abstract
Objectives Medication refill processing is a repetitive and predictable time-intensive task for ambulatory primary and specialty care. Refill protocols are a clinical decision support (CDS) tool that allows clinicians to quickly and safely determine appropriateness of a refill request. Our health system opted to improve the quality and breadth of electronic health record vendor-supplied protocols to consistently leverage best practices and emerging evidence and to create novel protocols that further support clinicians.
Methods We established a refill protocol governance group to guide new protocol build and to review existing protocols regularly to keep current with emerging guidelines. Data-driven prioritization was used to create new protocols for the most frequently refilled medications, as well as for less-prescribed but higher risk medications. Ad-hoc specialist inclusion as subject-matter experts provided greater detail, accuracy, and broader consensus in protocol criteria.
Results Approximately 11 million refills are processed each year by our health system's providers. The proportion of refill requests supported by a protocol increased over a 2-year period from 49 to 82%, representing a net increase of 3.63 million refills in the second measurement year as compared to the start of the first measurement year. All published refill protocols were reviewed by the governance group over the measurement years for compliance with clinical guidelines. In addition to the structure of the refill protocols' CDS, the process was supported by filters that enable practices to quickly approve refills that pass protocol, providing more time for clinicians to review refills that fail a protocol or for which no protocol exists.
Conclusion A refill protocol is a valuable CDS tool that can improve efficiency, effectiveness, and user satisfaction when processing refill requests. A refill protocol governance structure is an effective way to review, edit, and build refill protocols within a health system.
Physician Perspectives on Implementation of Real-Time Benefit Tools: A Qualitative Study
Authors: Everson Jordan , Whitmore Christine C. , Mattingly T. Joseph , Sinaiko Anna D. , Dusetzina Stacie B. 
Published: September 2022

Abstract
Objectives Congress and Medicare have required real-time benefit tools (RTBT) to provide patient-specific medication price information during prescribing to decrease the cost of medications. We sought physicians' perspectives on how these tools might most effectively improve their selection of low-cost medication.
Methods We conducted 15 semi-structured interviews of physicians (6 oncologists, 1 endocrinologist, 4 rheumatologists, and 4 from internal medicine) and identified key themes across interviews during coding and analysis.
Results Although physicians saw value in real-time medication price information, they were wary of the complexity of obtaining specific information and the potential for inaccuracies. Physicians described how medication price information would be used in various prescribing scenarios including from simple substitutions (different drug formulations) to more complex decisions (different drug classes). In more complex situations, physicians were concerned that price information might only be available after discussing options with the patient, which would be too late to inform decisions. Concern about adding more information to the electronic health record was common.
Conclusion While most physicians saw value in implementation of RTBTs, they also expressed concerns related to the accuracy of information, the availability of information at the right time in the clinical workflow, and the most effective format for information. Many concerns raised paralleled the “Five Rights of Clinical Decision Support” framework and indicate the need for additional design work to achieve benefit from RTBTs. Beyond the public policy that has supported the availability of RTBTs, substantial development will be required to ensure that information is used to improve prescribing decisions.
Trigger Wrist with Carpal Tunnel Syndrome Accompanied with Trifid Median Nerve: A Case Report and Literature Review
Authors: Oh Sangho 
Published: September 2022

AbstractTrigger wrist, characterized by a clicking or snapping sensation around the wrist joint during finger or wrist motion, and bifid or trifid median nerve, which occurs in carpal tunnel syndrome along with anatomical variation of median nerve, are rare conditions. We report the case of a patient with a thickened tendon caused by severe tenosynovitis and flexor tendon subluxation to the hamate hook due to bowing of the flexor retinaculum, thereby resulting in trigger wrist as well as an anatomical median nerve variation (bifid median nerve in the right wrist and trifid median nerve in the left wrist). A 59-year-old housewife visited our hospital with bilateral fingertip numbness, tingling sensation, and aggravated severe night cramping that began 2 months ago. She also complained about trigger wrist during small finger flexion. Based on magnetic resonance imaging, ultrasonography, and nerve conduction study, trifid median nerve and bilateral severe median nerve neuropathy of the wrist were diagnosed; therefore, transverse carpal tunnel release and exploration under wide-awake anesthesia were planned. Intraoperative findings showed trifid and bifid median nerves in left and right wrists, respectively. Additionally, bowing of flexor retinaculum and severe flexor tendon tenosynovitis were observed. Tenosynovitis with thickened flexor sheath resulted in subluxation of the small finger flexor tendon above the hamate hook. After transverse carpal ligament release with antebrachial fascia release and tenosynovectomy, subluxation of the flexor tendon was resolved. At 6 months postoperatively, the tingling and dullness in fingertips also resolved, and no trigger wrist or any other complications were noted.
Association of Immune-Related Adverse Effects and Survival in Solid Tumor Patients Treated with PD1 Inhibitors
Authors: Kapoor Akhil , Noronha Vanita , Patil Vijay M. , Joshi Amit , Menon Nandini , Kumar Amit , Mahajan Abhishek , Janu Amit , Kumar Rajiv , Prabhash Kumar 
Published: September 2022

Background The development of immune-related adverse effects (irAEs) can corroborate with the response to immune checkpoint inhibitors (ICIs), including programmed cell death 1 (PD1) inhibitors. However, there is extremely limited data on the association of irAEs with survival in patients who have shown a response to ICIs.Patients and Methods This study is a retrospective audit of the prospectively collected database of patients who received PD1 inhibitors for advanced solid tumors. Responders were defined as patients who attained the best response of either complete response or partial response. Time-to-event analysis was done using the Kaplan–Meier estimator, and the hazard ratio (HR) was calculated by using Cox proportional model. A point-biserial correlation was used to find out the potential influence of irAEs on overall survival (OS).Results A total of 155 patients (49% lung cancer, 31% head and neck cancer) who received ICI during the specified period were evaluated for this study. The overall response rate was 19.4% and disease control rate was 43.2%. The median (OS) for patients who developed irAE was 12.3 months (95% confidence interval [CI]: 8.9–15.6), while it was not reached for patients without irAE (HR: 10.5, 95% CI: 1.2–NR, p = 0.007). One-year OS for the corresponding group of patients was 53.6% (standard deviation [SD]: 15.6) versus 92.9% (SD: 6.9), respectively. Among responders, 12 (40%) developed at least grade 1 irAE, while among nonresponders, 38 (30.4%) developed irAE (p = 0.312).Conclusions In our study, we found significant improvement in survival of solid tumor patients treated with ICIs who developed irAEs on treatment as compared with those who did not. On specifically analyzing patients who responded to ICIs, there was no difference in OS who developed irAEs versus those who did not. However, this needs to be studied in a larger sample to reach a definite conclusion.
Translation and Pilot Validation of the EORTC QLQ-NHL-HG29 Module in Indian Languages (Hindi and Marathi) for Use in Indian Patients with Non-Hodgkin's Lymphoma
Authors: Patil Roshankumar , Palwe Vijay , Pandit Prakash , Kate Shruti , Paleja Nishtha , Badarkhe Girish , Wasekar Nilesh , Bhamre Rasika , Yasam Ramesh Venkata , Nagarkar Raj 
Published: September 2022

Background Cancer and its related treatments have a huge impact on a patient's quality of life (QOL). To measure such QOL in cancer patients, the European Organization for Research and Treatment of Cancer (EORTC) has introduced various scales/questionnaires for various cancers. In the present study, we aimed to translate and validate high-grade Non-Hodgkin's lymphoma (NHL-HG) English questionnaire (EORTC QLQ-NHL-HG29) into Hindi and Marathi (two of the most popular Indian language) to make it available for patients and the scientific community.Materials and methods The EORTC QLQ-NHL-HG29 was translated into Hindi and Marathi languages as per EORTC guidelines. The translated questionnaire was pilot-tested in a sample of 20 patients (10 for each translation) with NHL-HG.Results After procuring required approvals from EORTC, the existing QLQ-NHL-HG29 English questionnaire was translated (forward and backward) into vernacular languages (Hindi and Marathi). Later, the translations were sent to EORTC for evaluation and all the queries raised by EORTC toward translations were discussed and included in the final questionnaires as per EORTC guidelines. On receiving approval from EORTC translation coordinator, pilot study was conducted in 20 patients. In the pilot study, 10 patients were given the Hindi questionnaire and other 10 patients were given the Marathi questionnaire. Based on the pilot testing interpretations or suggestions from the patients, all the necessary modifications were incorporated in the questionnaires and sent to EORTC for validation and approval.Conclusion Both the translations (Hindi and Marathi) submitted to the EORTC have now been approved (QLQ-NHL-HG29) by the EORTC-QOL unit and after procuring necessary permissions from the EORTC both of these translations can be used reliably in clinical practice and clinical trials to assess QOL in patients suffering from NHL-HG.
Role of Molecular Targeted Therapeutic Drugs in Treatment of Oral Squamous Cell Carcinoma: Development and Current Strategies—A Review Article
Authors: Singh Himanshu , Patel Vedant 
Published: September 2022

AbstractBecause of active advancement in the field of biomedicine, people have in-depth knowledge of biological nature of malignant tumors and are able to recognized the overexpression of different molecules such as vascular endothelial growth factor receptor, cyclin-dependent kinase, and programmed cell death receptor. Presently, various targeted therapeutic drugs are used in different clinical trials in those patients suffering from oral squamous cell carcinoma. In this review, we converse about the various targeted therapeutic drugs and their advancement in the treatment of oral squamous cell carcinoma. This review scrutinizes the existing documentation in the literature related to the targeted therapies for oral squamous cell carcinoma. English language articles were searched in various databases such as PubMed, Scopus, Science Direct, and Google Scholar. The keywords used for searching are “oral squamous cell carcinoma,” “targeted therapy,” and “therapeutic drugs.”
4.4.38.14 Propargylsilanes (Update 2022)
Authors: Jackowski O. , Perez-Luna A. 
Published: September 2022

AbstractThis review is an update to the earlier Science of Synthesis coverage of the synthesis of propargylsilanes (Section 4.4.38). It covers the literature published between 2000 and 2021.Propargylsilanes can be prepared by a rather large array of methods that rely either on reactions involving C–Si bond formation, or on the manipulation of organosilicon-containing precursors to install a C≡C triple bond. For the first strategy, electrophilic silylation of propargyl or allenyl metals by reaction with halosilanes is the most frequently encountered; however, approaches such as propargylic carbene insertions into hydrosilanes, nucleophilic substitution or addition reactions with silylboranes and other silylmetals, or the rearrangement of propargylic silyl ethers have been developed more recently to diversify the silicon source. For the second type of approach, in addition to established transformations such as alkynylation of silylmethyl halides, α-silyloxiranes, or acylsilanes, the allylic substitution of allylic phosphates or elimination reactions of heteroatom-substituted allylsilanes have also recently gained interest. Moreover, a large body of work has been devoted to accessing elaborated propargylsilanes from simple pre-existing propargylsilane units through functionalization at the acetylenic carbon. Given the relevance of propargylsilanes in the context of stereoselective synthesis, there is persistent interest in the preparation of chiral, nonracemic propargysilanes, and significant progress in this area has been achieved over the last two decades, notably through the implementation of asymmetric catalysis.
15.4.5 Quinolinones and Related Systems (Update 2022)
Authors: Silva V. L. M. , Pinto D. C. G. A. , Santos C. M. M. , Rocha D. H. A. 
Published: September 2022

AbstractQuinolinones, of which the quinolin-4(1H)-one ring system can be highlighted, represent an exciting class of nitrogen heterocycles. The quinolinone motif can be found in many natural compounds and approved drugs for several diseases. This chapter is a comprehensive survey of the methods for the synthesis of quinolin-2(1H)-ones, quinolin-4(1H)-ones, and their thio- and amino derivatives, and is an update to the previous Science of Synthesis chapter (Section 15.4), covering the period between 2003 and 2020.
48.2.3 Cyclopropanes (Update 2022)
Authors: Tang X. 
Published: September 2022

AbstractCyclopropanes represent an interesting class of strained rings and serve as versatile building blocks in organic synthesis. Furthermore, cyclopropane moieties are also found in many bioactive compounds and natural products. Reviewed herein are synthetic strategies to access mono- and polysubstituted cyclopropyl cores. In particular, the application of visible-light photoredox catalysis in the synthesis of cyclopropanes is introduced.
Laser-induced galfenol embedded multi-layer graphene-oxide in solution
Authors: Duryea Devyn , Kandadai Nirmala 
Published: September 2022

The proposed work demonstrates the direct synthesis of nanomaterial-embedded laser-induced few-layer graphene-oxide by directly ablating galfenol in a water-based solution for the first time. Laser-induced multilayer graphene-oxide (GO) embedded with galfenol (gallium–iron alloy) nanoparticles (NPs) is created through a method of direct laser inscription of bulk galfenol in deionized (DI) water with femtosecond laser ablation. The NP-embedded GO is achieved by irradiating a near-infrared (near-IR) femtosecond laser at 1040 nm on a bulk galfenol material submerged in a solution comprising DI water and a small concentration (5%/wt.) of polyvinylpyrrolidone followed by a second ablation in pure DI water. Results show nanoparticles with a mean diameter of ∼30 nm embedded in GO sheets with visible folds spaced at ∼0.63 nm. The composition of iron and gallium shifts by less than 2% during the laser ablation process, and the few-layer GO sheets exhibit similar Raman peaks to bulk graphite.
Analysis of recombination centers near an interface of a metal–SiO2–Si structure by double carrier pulse deep-level transient spectroscopy
Authors: Hara Tomohiko , Ohshita Yoshio 
Published: September 2022

This paper proposes a new double carrier pulse deep-level transient spectroscopy (DC-DLTS) method that is applicable for evaluating metal–insulator–semiconductor (MIS) structures and the recombination centers in carrier-selective contact solar cells. Specifically, this study evaluated recombination characteristics of defects induced in bulk Si near SiO2/Si interfaces by reactive plasma deposition (RPD). In this method, a pulse voltage was first applied to inject majority carriers. Subsequently, a second pulse voltage was applied, which allowed minority carriers to be injected into the MIS structure. With these two types of carrier injections, carriers were recombined in recombination-active defects, and the DC-DLTS spectrum changed. During the injection of minority carriers, some majority carriers were thermally emitted from the defects, resulting in a decrease in the signal intensity. The recombination activity was analyzed by considering the effect of thermal emission on the change in signal intensity. The number of induced defect types and defect properties were estimated using Bayesian optimization. According to the results, three types of electron traps were generated using the RPD process. Based on the DC-DLTS results, defects with energy level 0.57 eV below the conduction band and capture cross section of ∼10−15 cm2 act as recombination centers.