bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Exercise Frequency and Intensity on Reducing Depressive Symptoms in Older Adults With Insomnia: A Pilot Randomized Controlled Trial
Authors: Chin Edwin C. , Yu Angus P. , Leung Chit K. , Bernal Joshua D. , Au Whitney W. , Fong Daniel Y. , Cheng Calvin P. , Siu Parco M. 
Published: April 2022

BackgroundThe effects of exercise frequency and intensity on alleviating depressive symptoms in older adults with insomnia are unclear.PurposeThe purpose of this study was to investigate the influence of different exercise frequencies and intensities on prescribed aerobic-type physical activity (i.e., 75 min of vigorous-intensity exercise or 150 min of moderate-intensity exercise weekly) for reducing depressive symptoms in older adults living with insomnia, as recommended by the WHO.DesignThis study is a randomized, controlled, assessor-blinded trial.SettingThis study is conducted at a single research site in Hong Kong.ParticipantsThis study includes older adults aged 50 years or above with depressive symptoms and insomnia.InterventionParticipants were randomly assigned in a 1:1:1:1:1 ratio to the following groups: attention control (CON), moderate walking once weekly (MOD × 1/week), moderate walking thrice weekly (MOD × 3/week), vigorous walking once weekly (VIG × 1/week), and vigorous walking thrice weekly (VIG × 3/week). The total weekly exercise volumes among the walking groups were matched to the minimum recommended physical activity volume.MeasurementsDepression, anxiety, self-perceived sleep quality, insomnia severity, actigraphy-assessed 7-day sleep data, 7-day sleep diary, cardiorespiratory fitness, adherence, and habitual physical activity were examined at baseline and after 12 weeks of intervention.ResultsBoth MOD × 3/week and VIG × 3/week groups demonstrated reduced depression (Hospital Anxiety and Depression Scale [HADS] – Depression: MOD × 3/wk: −68.6%; VIG × 3/week: −67.4%) and anxiety levels (HADS – Anxiety: MOD × 3/week: −54.3%; VIG × 3/week: −59.8%) compared with CON (both p &lt; 0.01). Self-perceived sleep quality was improved in MOD × 3/week (−31.4% of the Pittsburgh Sleep Quality Index [PSQI]), VIG × 1/week (−34.1% of PSQI), and VIG × 3/week (−38.3% of PSQI), but not in MOD × 1/week, when compared with CON (p &lt; 0.05). No serious adverse events were observed in this study.ConclusionThe effects of walking training on reducing depressive symptoms appeared to be dependent on exercise frequency. Our findings suggest that three sessions of walking per week at either moderate or vigorous-intensity effectively alleviate depressive symptoms in older adults with insomnia. Additional research is needed to further verify the effects of exercise frequency on depression.Clinical Trial Registration[ClinicalTrials.gov], identifier [NCT04354922].
Association of Parental Famine Exposure With Offspring Depression and Cognition Function
Authors: Liu Ye , Liu Yu , Lu Yuzhu , Li Jiangping , He Shulan 
Published: April 2022

BackgroundThe effect of early exposure to famine on depression and cognition in adulthood has been shown, but the intergenerational association of famine remain to be explored. This study focused on exploring the association of parental famine exposure with depression and cognition in the offspring.MethodsBased on the Chinese Family Panel Studies database, which is a longitudinal survey, we included 5,150 individuals born between 1959 and 1961 and divided them into fetal-exposed, infancy-exposed (birth year = 1957–1958), school-age-exposed (birth year = 1949–1956), adolescent-exposed (birth year = 1946–1948), and unexposed groups. We used one-way analysis of variance, multiple linear regression, and one follow-up measurement to analyze the association between parental famine exposure and offspring depression and cognitive function.ResultsCompared with the unexposed group, the correlations between parental famine exposure during fetal period and their cognitive function (mother: β = –1.614, 95% CI: –2.535, –0.693; p = 0.001; father: β = –2.153, 95% CI: –3.104, –1.202, p &lt; 0.001) were significant. For the offspring, there was a negative correlation between famine exposure of fathers during the fetal period and depression in their offspring (β = –0.477, 95% CI: –0.907, –0.047; p = 0.030). There was a negative correlation between maternal famine exposure during the infant and adolescent period and cognitive function in the offspring (math test: β = –0.730, 95% CI: –1.307, –0.153; p = 0.013; word test: β = –2.346, 95% CI: –4.067, –0.625; p = 0.008).LimitationsNot all variables related to depression and cognition function were included in the CFPS database, and the other unknown or unmeasured confounders may explain our results.
Exploring Potential Regulatory Anesthetic Drugs Based on RNA Binding Protein and Constructing CESC Prognosis Model: A Study Based on TCGA Database
Authors: Zheng Ying , Meng Xiao Wen , Yang Jian Ping 
Published: April 2022

ObjectiveTo investigate the differential expression of RBPs in cervical squamous cell carcinoma (CESC), analyze the regulatory effect of narcotic drugs on RBPs, and establish the prognostic risk model of CESC patients.MethodsRNA-SEQ data and clinical case data of cancer and normal samples from CESC patients were obtained from the Cancer Genome Atlas (TCGA) database and Genotype-Tissue Expression (GTEx) database. Differentially expressed RBPs were screened by R language and enriched. The CMAP database is used to predict the anesthetic drugs that regulate the differential expression of RBPs. The prognostic risk score model was constructed by COX regression analysis. Risk score of each CESC patient was calculated and divided into high-risk group and low-risk group according to the median risk score. The prediction efficiency of prognostic risk model was evaluated by Kaplan-Meier (KM) analysis and receiver operating characteristic (ROC) curve, and the correlation between prognostic risk model and clinical characteristics was analyzed. Immunohistochemistry was used to detect the expression of RNASEH2A and HENMT1 in tissues.ResultsThere were 65 differentially expressed RBPs in CESC. Five anesthetics, including benzocaine, procaine, pentoxyverine, and tetracaine were obtained to regulate RBPs. Survival analysis showed that seven genes were related to the prognosis of patients, and the CESC risk score model was constructed by COX regression. The risk score can be used as an independent prognostic factor. RNASEH2A and HENMT1 are up-regulated in tumors, which can effectively distinguish normal tissues from tumor tissues.ConclusionIt is found that different anesthetic drugs have different regulatory effects on the differential expression of RBPs. Based on the differentially expressed RBPs, the prognostic risk score model of CESC patients was constructed. To provide ideas for the formulation of individualized precise anesthesia scheme and cancer pain analgesia scheme, which is helpful to improve the perioperative survival rate of cancer patients.
Isolated Tubal Torsion in a Term Pregnancy: Case Report and Systematic Review of Literature of the Last 10 Years
Authors: Gulino Ferdinando Antonio , Ettore Carla , Morreale Gianfranco , Siringo Stefano , Russo Emanuele , D'Asta Marco , Cannone Francesco , Ettore Giuseppe 
Published: April 2022

ObjectiveIsolated torsion of a fallopian tube is a rare event and it is extremely difficult to be diagnosed in pregnancy. The aim of this study is to present a clinical case report that occurred in our department and to summarize the latest evidence about tubal torsion in pregnancy.MethodsWe reported data, ultrasonographic features and an intra-operative image of a case report of tubal torsion in a term pregnancy. Then a review of the literature was performed following the PRISMA statement: we searched all the articles related to tubal torsion in pregnancy in the last 10 years from the international electronic bibliographic database PUBMED. We collected data regarding population characteristics, clinical features, treatment, and feto-maternal outcomes.ResultsAccording to our search strategy, 10 articles were included. The main clinical symptoms were abdominal pelvic pain (100%), nausea, and vomiting (30%). The mean gestational age at the diagnosis was 36 weeks after the last menstrual period in 50% of cases. Ultrasound images showed a cystic lesion in the adnexal area in 70% of cases. In most of the cases, a cesarean section with a contextual salpingectomy was performed. No cases of maternal and fetal death were respectively reported.ConclusionIsolated torsion of the fallopian tube is a rare obstetric condition but it should be considered in case of acute lower abdominal pain presentation during pregnancy. Depending on gestational age, surgical treatment as soon as possible could prevent a salpingectomy.
NTH2 1271_1272delTA Gene Disruption Results in Salt Tolerance in Saccharomyces cerevisiae
Authors: Hernández-Soto Alejandro , Delgado-Navarro José Pablo , Benavides-Acevedo Miguel , Paniagua Sergio A. , Gatica-Arias Andres 
Published: April 2022

Trehalose is a common energy reservoir, and its accumulation results in osmotic protection. This sugar can accumulate through its synthesis or slow degradation of the reservoir by trehalase enzymes. Saccharomyces cerevisiae contains two neutral trehalases, NTH1 and NTH2, responsible for 75% and 25% of the enzymatic metabolism. We were interested in the loss-of-function of both enzymes with CRISPR/Cas9. The later NTH2 was of great importance since it is responsible for minor metabolic degradation of this sugar. It was believed that losing its functionality results in limited osmotic protection. We constructed an osmotolerant superior yeast capable of growing in 0.85 M NaCl after independent nth21271_1272delTA mutation by CRISPR/Cas9 technology, compared with nth1 893_894insT and wild type. We suggest that this yeast model could give clues to breeding commercial yeast resulting in non-GMO salinity-tolerant strains.
Highly Efficient and Rapid Removal of Methylene Blue from Aqueous Solution Using Folic Acid-Conjugated Dendritic Mesoporous Silica Nanoparticles
Authors: Almethen Abdurrahman A. , Alotaibi Khalid Mohammed , Alhumud Haitham S. , Alswieleh Abdullah M. 
Published: April 2022

Dendritic Mesoporous Silica Nanoparticles (DMSNs) are considered superior in the adsorption of unfavorable chemical compounds and biological pollutants. Herein, we have synthesized folic acid-terminated dendritic mesoporous silica nanoparticles (FA-DMSN) for the removal of cationic dyes, methylene blue (MB), from aqueous solutions. The structural, morphological, functional, specific surface area, pore size distribution, and thermal properties of the synthesized DMSNs were identified using a scanning electron microscope (SEM), a transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), Brunauer−Emmett−Teller (BET), and Thermogravimetric Analyzer (TGA). The synthesized DMSNs exhibited a high surface area (521 m2 −1) and pore volume (1.2 cm3 g−1). In addition, it features both wide pore size and narrow distributions, which strongly affect the adsorption performance in terms of the equilibrium uptake time. Moreover, the impact of pH, contacting time, and dye’s initial concentration on the removal efficiency of MB was studied. The extraction efficiency of FA-DMSN was found to be three times more effective than the bare DMSN materials. Langmuir isotherm fitted the experimental data very well with a correlation coefficient value of 0.99. According to the Langmuir model, the maximum adsorption capacity was 90.7 mg/g. Furthermore, the intra−particle diffusion model revealed a significantly fast intra-particle diffusion which can be attributed to the presence of the large pore’s channels. Finally, the fast adsorption of MB molecules, reaching their equilibrium capacity within tens of seconds, as well as the low cost and ease of FA-DMSN fabrication, makes the developed material an effective adsorbent for water remediations.
Long term clinical outcome following decompressive surgery for Cauda Equina Syndrome
Authors: Kumar Lohar Vishnu , Gaurav Jaiswal , Kumar Gupta Tarun , Kumar Jain Sachin , Govind Lodha Krishna , Kaushal Yadav 
Published: April 2022

Study design: Retrospective study with prospective long-term clinical follow-up.
Background: Cauda equina syndrome (CES) is a neurosurgical emergency, mostly caused by herniated lumbar disc for which urgent surgical decompression is indicated. Data on long-term clinical outcome of bladder, bowel & sexual function following decompression are elusive.
Aim: To evaluate the effectiveness of surgical decompression on recovery of CES symptoms at long-term follow-up & role of timing of surgery on the outcome.
Methods: Records of 35 CES patients who underwent surgical decompression for herniated lumbar disc during a five years period retrospectively analysed & patients called for follow-up visits. Outcome measures comprised of history & clinical examination pertinent to bladder, bowel & sexual function.
Results: Twenty-four patients (68.5%) were included for final evaluation who attended follow-up visits, with a minimum follow-up period of one year. Most common complaint at presentation was bladder dysfunction (100%) with urinary retention in 16 patients (66.6%), faecal incontinence in 11 (45.8%), saddle anaesthesia in 22 (91.6%) & erectile dysfunction in 6 patients (out of 15 males). Only four patients underwent surgery within 48 hours of CES symptom onset, rest cases after 48 hours duration. At follow-up, bladder dysfunction present in 33.3% with urinary retention in 16.6%. Faecal incontinence persisted in 4 patients (16.6%) & saddle anaesthesia in 7 (29.1%). Sexual dysfunction was the most persistent complaint.
Conclusion: Long-term follow-up shows significant recovery of sphincteric function in CES patients after surgical decompression. Urinary & bowel dysfunction improve significantly. Timing to surgery didn’t affect the long-term outcome.
Letter to the editor. Face-off between glioma and meningioma
Authors: Chouksey Dinesh , Goyal Nitisha , Garg Rishu , Sodani Ajoy K. 
Published: April 2022

Gliomas are malignant, and intrinsic cerebral tumours may cause tumour-infiltrative oedema. Meningiomas are mostly benign, extrinsic cerebral tumours that do not infiltrate the surrounding parenchyma. Meningiomas may give rise to vasogenic oedema in the peritumoral tissue.[1] The radiological diagnosis of cerebral tumours may be non-conclusive on conventional MRI in few cases, and diagnosis must rely on histopathological analysis. [2] We report a case that has an atypical clinical presentation with nonconclusive MRI brain, and finally, histopathology confirmed the diagnosis.
Clinicopathological features, imaging characteristics and surgical management in a novel tumour entity - aggressive meningiomas
Authors: Popescu G. , Paslaru Francesca , Paslaru A.C. , Apostol M. , Zaharia M.C. , Corneliu T. , Mitrica M. , Popescu M. , Gorgan R.M. 
Published: April 2022

Meningiomas are common neoplasms of the central nervous system, comprising between 24 and 30% of primary intracranial tumours, most commonly affecting females in their middle age or later adult life [1] [2].
Meningiomas are classified as benign, atypical or anaplastic meningiomas depending mostly on histopathological criteria known to be associated with worse prognosis in terms of tumour progression, recurrence risk after surgery and overall survival. The 2016 edition of the World Health Organization (WHO) classification of Central Nervous System (CNS) tumours recognizes brain invasion as an independent criterion for diagnosing an atypical grade II meningioma [3]. Meningioma grading based on the WHO classification of CNS tumours thoroughly impacts therapeutic management and tumour prognosis.
Aggressive meningiomas, a different phenotype of tumours, characterized by rapid growth and involvement of adjacent brain tissue, blood vessels and bone, was not previously listed as an independent entity in the WHO classification of meningothelial-cell tumours.
Regarding the increasing importance of tumour grading in meningioma treatment strategies, the authors here provide an overview of clinicopathological and radiographic features, surgical management and long-term prognosis of this novel meningothelial tumour entity, the aggressive meningioma. In particular, we aimed to describe pre-, intra- and postoperative methods for recognizing aggressive meningiomas and explore the implications of this diagnosis on both surgical strategies and adjuvant therapy.
The complementary multimodal treatment of recalcitrant cerebral aneurysms
Authors: Deniwar Mohamed Adel , Kassem Mohamed , Ezzeldin Ashraf , Jafar Jafar J. 
Published: April 2022

Background: The main treatment of cerebral aneurysms is direct surgical clipping or endovascular coil embolization. However, some cerebral aneurysms that we reviewed in the literature are still not susceptible to a single treatment approach. These aneurysms can be referred to as complex aneurysms.
Objective: We aim to report these aneurysms and share our clinical experience with their treatment and diagnosis.
Methods: All cases of cerebral aneurysms treated in New York University and in Mansoura University from 2010-2021 were retrospectively reviewed.
Results: 18 patients with 21 cerebral aneurysms were treated by combined surgical and endovascular modalities. Aneurysms associated with arteriovenous malformations (AVMs) in 3 patients, associated with vasospasm in 7 patients, and 3 patients had double aneurysms. A total of 18 patients with aneurysms were treated with combined endovascular and microsurgical therapy. Early angiogram (< 1 week) revealed; complete obliteration of 19 aneurysms (90%) out of a total of 21 aneurysms, residual filling was observed in 2 aneurysms (10%). Late radiological follow up (> 3 months- 2 years) revealed; a stable residual filling in one and the other case underwent retreatment.
Conclusions: The recalcitrant or complex cerebral aneurysms can be better referred to as diseases rather than lesions as many clinical and anatomical factors make their treatment difficult. Endovascular and microsurgery could be complementary to each other and create a multimodal approach for treating them.
Correlation of neutrophil lymphocyte ratio to clinical outcomes based on 6 months surveillance on traumatic brain injury patients at Haji Adam Malik General Hospital
Authors: Lizen Nindi , Dharmajaya Ridha , Sastrodiningrat Abdul Gofar , Mahyudanil Mahyudanil 
Published: April 2022

Introduction: Traumatic brain injury is a major cause of disability, death, and economic loss in many countries around the world. The annual incidence in the United States is reported to reach 1.7 million sufferers, in Europe it is reported as 262 per 100,000 people per year, and in Indonesia, the incidence is increasing by 1% every year. Direct and indirect damage resulting from a traumatic brain injury can cause inflammation by activating glial cells and leukocytes, inducing the release of proinflammatory cytokines, and accelerating neurodegeneration and neuroinflammation. Recently, the neutrophil-to-lymphocyte ratio (NLR) has been proposed to be a predictor of clinical outcomes for various neurological diseases such as stroke and traumatic brain injury. To put it simply, elevated NLR levels in patients with intracerebral haemorrhage were independently associated with worse clinical outcomes. Researchers want to research the relationship between NLR and outcome based on 6 months GOS in traumatic brain injury patients at Haji Adam Malik General Hospital Medan.
Methods: An observational analytic study with a retrospective cohort design. Samples were selected based on inclusion and exclusion criteria from a traumatic brain injury at H. Adam Malik General Hospital Medan in 2018-2020.
Results: The research data were normally distributed and analyzed by the Pearson trial; the sig value was obtained. (2-tailed) of 0.798 (P > 0.05), which means there is no between NLR and 6 months GOS outcome in traumatic brain injury patients.
Conclusion: There was no relationship between NLR and outcome based on GOS 6 months of traumatic brain injury patients.
The impact of COVID-19 pandemic on the diagnostic distribution in dermatology outpatient clinic
Authors: COŞANSU Nur Cihan , YALDIZ Mahizer , SEVİMLİ DİKİCİER Bahar , ERKORKMAZ Ünal 
Published: April 2022

Objective
The admission frequency of diseases, including dermatological diseases, has changed after the COVID-19 outbreak. The aim of this study was to evaluate the change in the diagnosis distribution of dermatology outpatient clinics during the COVID-19 outbreak by comparing it with the same period of the last year.
Materials and Methods
The International Codes of Diseases (ICD-10) categories and patient's diagnoses were evaluated before and after the pandemic. All patients, who applied to the dermatology outpatient clinic between June 1, 2020, and September 1, 2020, were included in our study. This information was compared with the same period of the previous year.
Results
The hospital admissions were found reduced by 42.6%. The ratio of the patients with dermatophytosis, anogenital warts, scabies, seborrheic keratosis, urticaria, and xerosis cutis was significantly increased (p < 0.05), while the ratio of patients with actinic keratosis, callosities and corns, allergic contact dermatitis, lichen simplex, melasma, mycosis fungoides, nail disorders, nevi, prurigo nodularis, pruritus, psoriasis, and warts were significantly decreased after the COVID-19 pandemic (p < 0.05).
Conclusions
This is the first study on the frequency and most common types of outpatient dermatology visits, during the period of restriction reduction 3-6 months after the coronavirus pandemic. Many factors such as restrictions and hygiene practices, that affecting the quality of life, may cause changes in the diagnostic distribution of dermatology.
Bibliometric Analysis of Publications on Vertebral Osteomyelitis Infections
Authors: ALIRAVCI Işıl Deniz 
Published: April 2022

Objective: Vertebral osteomyelitis is defined as an infection of the intervertebral disc and the disc space of the adjacent vertebrae, which causes mortality and morbidity. This disease has started to be detected more frequently due to increased diagnostic possibilities. In this study, we aimed to review the contribution of the increasing number of cases to the scientific literature.
Method: This bibliometric analysis study was carried out by searching the keywords "vertebral osteomyelitis (VO)" or "spondylodiscitis" in Scopus database of Elsevier. English was chosen for the searching language. The distribution of the number of publications by years was evaluated in terms of the institution in which the publications were made, the language of the publication, the country, the author, the institutions providing financial support, the number of citations and the journal in which they were published.
Results: It was determined that there were 2679 publications on vertebral osteomyelitis(VO). First publication was published in 1911. While there was very few publication on this subject until 1937, the number of publications after year 1980s were increased (Graph 1). A total number of 1924 (71.81%) were published after the year 2000. The authors with the highest number of articles in this field were Louis Bernard (16 publications) and Aurélien Dinh (16 publications) from France. A total number of 2576 (96.15%) publications were published in the field of medicine. There were publications on VO in 20 different disciplines, from nursing to veterinary. The publications were consisted of 2123 (79.24%) articles, 261 (9.7%) of them are not categorized, 9 (0.33%) letters to the editor, 150 (5.59%) reviews, and 136 (5.07%) other types of studies (conference papers, notes, book chapters, etc.). The dominant language of publication was English (1992, 74.35%). The most scientifically productive countries on VO were United States (n=452, 16.87%), France (n=303, 11.31%) and Germany (n=248, 9.25%).
Conclusion: It is necessary to support scientific activities on VO and increase the number of publications made globally.