bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sub‐Seasonal Forcing Drives Year‐To‐Year Variations of Southern Ocean Primary Productivity
Authors: Prend Channing J. , Keerthi M. G. , Lévy Marina , Aumont Olivier , Gille Sarah T. , Talley Lynne D. 
Published: June 2022

AbstractPrimary productivity in the Southern Ocean plays a key role in global biogeochemical cycles. While much focus has been placed on phytoplankton production seasonality, non‐seasonal fluctuations exceed the amplitude of the seasonal cycle across large swaths of the Antarctic Circumpolar Current. This non‐seasonal variability comprises a broad range of timescales from sub‐seasonal (<3 months) to multi‐annual (>1 year), all of which can project onto the annual mean value. However, year‐to‐year variations of surface chlorophyll (SChl), a proxy for phytoplankton biomass, are typically attributed to ocean circulation changes associated with the Southern Annular Mode (SAM), which implicitly assumes that sub‐seasonal variability averages to near‐zero over long timescales. Here, we test this assumption by applying a timeseries decomposition method to satellite‐derived SChl in order to separate the low‐frequency and high‐frequency contributions to the non‐seasonal variability. We find that throughout most of the Southern Ocean, year‐to‐year SChl variations are dominated by the sub‐seasonal component, which is not strongly correlated with the SAM. The multi‐annual component, while correlated with the SAM, only accounts for about 10% of the total SChl variance. This suggests that changes in annual mean SChl are related to intermittent forcing at small scales, rather than low‐frequency climate variability, and thus do not remain correlated over large regions.
Solar Wind Speed Prediction via Graph Attention Network
Authors: Sun Yanru , Xie Zongxia , Wang Haocheng , Huang Xin , Hu Qinghua 
Published: June 2022

AbstractThe solar wind is a plasma flow formed by the expansion of the high‐temperature corona and propagates in the interplanetary space with speeds between 200 km/s and 900 km/s. Accurate solar wind speed prediction and longer lead time will help mitigate the impact of solar storms on aerospace equipment and the Earth's magnetic field. Recently, most approaches do not explicitly capture the relationships between different solar wind features, and the prediction accuracy of 96‐hr is still not good enough. This paper elaborately designs an end‐to‐end model: Graph‐Temporal‐AR model (GTA) for solar wind speed prediction. First, our framework considers each feature as the node to construct the graph structure and adopts the graph attention module to learn the complex dependencies among features. Second, our approach employs the dilated causal convolution to extend the receptive field and prolong the prediction time. Furthermore, we leverage the autoregressive model to solve the scale insensitive problem of the neural network, making our model more robust. Specifically, we combine the OMNI data measured at Lagrangian Point 1 (L1) with the extreme ultraviolet images observed by the Solar Dynamics Observatory satellite to predict the solar wind speed at L1. Compared with the baseline models, GTA obtains significant performance improvements. Through visualization, we find GTA excavates the relationships between multiply variables without domain prior knowledge, which may help us find other unknown associations in heliophysics data sets. The data and code are available from https://github.com/syrGitHub/GTA.
Efficient transdermal delivery of functional protein cargoes by a hydrophobic peptide MTD 1067
Authors: Shin Hee Je , Bak Sun Uk , La Ha Na , Kang Jin Sun , Lee Hwa Hyun , Eom Hyo Jung , Lee Byung Kyu , Kang Hyun Ah 
Published: June 2022

AbstractThe skin has a protective barrier against the external environment, making the transdermal delivery of active macromolecules very difficult. Cell-penetrating peptides (CPPs) have been accepted as useful delivery tools owing to their high transduction efficiency and low cytotoxicity. In this study, we evaluated the hydrophobic peptide, macromolecule transduction domain 1067 (MTD 1067) as a CPP for the transdermal delivery of protein cargoes of various sizes, including growth hormone-releasing hexapeptide-6 (GHRP-6), a truncated form of insulin-like growth factor-I (des(1-3)IGF-I), and platelet-derived growth factor BB (PDGF-BB). The MTD 1067-conjugated GHRP-6 (MTD-GHRP-6) was chemically synthesized, whereas the MTD 1067-conjugated des(1-3)IGF-I and PDGF-BB proteins (MTD-des(1-3)IGF-I and MTD-PDGF-BB) were generated as recombinant proteins. All the MTD 1067-conjugated cargoes exhibited biological activities identical or improved when compared to those of the original cargoes. The analysis of confocal microscopy images showed that MTD-GHRP-6, MTD-des(1-3)IGF-I, and MTD-PDGF-BB were detected at 4.4-, 18.8-, and 32.9-times higher levels in the dermis, respectively, compared to the control group without MTD. Furthermore, the MTD 1067-conjugated cargoes did not show cytotoxicity. Altogether, our data demonstrate the potential of MTD 1067 conjugation in developing functional macromolecules for cosmetics and drugs with enhanced transdermal permeability.
Development and characterization of novelly grown fire-resistant fungal fibers
Authors: Zhang Xijin , Li Yanjun , Fan Xudong , Wnek Gary , Liao Ya-Ting T. , Yu Xiong 
Published: June 2022

AbstractThis study conducted a comprehensive characterization and analyses on the fire-resistant behaviors of novel fungal fibers grown with substrate containing Silica (Si) source at multiple scales. At micro-scale, the results of SEM showed that silica affected the physiological activities of fungi, with the extent of effects depending upon its concentration. Fourier-transform infrared (FTIR) spectra displayed the existence of Si–O–C chemical bonds in fungal fibers grown with Si source, indicating that Si source becomes a part of the structure of fungal fibers. Thermogravimetric analysis (TGA) and Microscale combustion calorimetry (MCC) of fungal fibers exhibit an early thermal decomposition of non-combustible components, which will potentially help release the thermal stress and mitigation of spalling when used in concrete. Compared with polypropylene (PP) fibers, fungal fibers have a lower thermal degradation rate, a higher residual weight, a lower heat release peak temperature, and less total heat of combustion; all of these indicate improved thermal stability and fire resistance, and a lower rate of function loss in case of a fire. Additionally, the thermal stability and fire resistance of fungal fibers were improved with the increase of Si source concentration in the nutrition medium. For example, addition of 2% Si source in the feeding substrate leads to a 23.21% increase in residual weight in TGA, and a 23.66 W/g decrease in peak heat release rate as well as a 2.44 kJ/g reduction in total heat of combustion in MCC. At laboratory scale, compared with PP fibers, fungal fibers grown with 2% Si source have a higher residual weight of 40.40%, a higher ignition temperature of 200.50 °C, and a declined flame height of 11.64 mm in real fire scenarios. Furthermore, only in the fungal fibers grown with Si source, partial burning occurred. In post-fire conditions, the microstructure of residual char from fungal fibers grown with higher content of Si source became denser, which would lead to a reduction of the fuel vapor release and heat transfer. FTIR spectra of residual char demonstrated that fungal fibers grown with Si source formed more stable chemical bonds with higher heat of chemical bond formation, contributing to improved thermal stability and fire resistance. Therefore, compared with traditional fibers used for fiber reinforced concrete, incorporating the new natural grown fibers will potentially further improve the fire resistance of concrete and mitigate the concrete spalling.
Near-infrared light reduces glia activation and modulates neuroinflammation in the brains of diet-induced obese mice
Authors: Saieva Salvatore , Taglialatela Giulio 
Published: June 2022

AbstractNeuroinflammation is a key event in neurodegenerative conditions such as Alzheimer’s disease (AD) and characterizes metabolic pathologies like obesity and type 2 diabetes (T2D). Growing evidence in humans shows that obesity increases the risk of developing AD by threefold. Hippocampal neuroinflammation in rodents correlates with poor memory performance, suggesting that it contributes to cognitive decline. Here we propose that reducing obesity/T2D-driven neuroinflammation may prevent the progression of cognitive decline associated with AD-like neurodegenerative states. Near-infrared light (NIR) has attracted increasing attention as it was shown to improve learning and memory in both humans and animal models. We previously reported that transcranial NIR delivery reduced amyloid beta and Tau pathology and improved memory function in mouse models of AD. Here, we report the effects of NIR in preventing obesity-induced neuroinflammation in a diet-induced obese mouse model. Five-week-old wild-type mice were fed a high-fat diet (HFD) for 13 weeks to induce obesity prior to transcranial delivery of NIR for 4 weeks during 90-s sessions given 5 days a week. After sacrifice, brain slices were subjected to free-floating immunofluorescence for microglia and astrocyte markers to evaluate glial activation and quantitative real-time polymerase chain reaction (PCR) to evaluate expression levels of inflammatory cytokines and brain-derived neurotrophic factor (BDNF). The hippocampal and cortical regions of the HFD group had increased expression of the activated microglial marker CD68 and the astrocytic marker glial fibrillary acidic protein. NIR-treated HFD groups showed decreased levels of these markers. PCR revealed that hippocampal tissue from the HFD group had increased levels of pro-inflammatory interleukin (IL)-1β and tumor necrosis factor-α. Interestingly, the same samples showed increased levels of the anti-inflammatory IL-10. All these changes were attenuated by NIR treatment. Lastly, hippocampal levels of the neurotrophic factor BDNF were increased in NIR-treated HFD mice, compared to untreated HFD mice. The marked reductions in glial activation and pro-inflammatory cytokines along with elevated BDNF provide insights into how NIR could reduce neuroinflammation. These results support the use of NIR as a potential non-invasive and preventive therapeutic approach against chronic obesity-induced deficits that are known to occur with AD neuropathology.
Collective dynamics of capacity-constrained ride-pooling fleets
Authors: Zech Robin M. , Molkenthin Nora , Timme Marc , Schröder Malte 
Published: June 2022

AbstractRide-pooling (or ride-sharing) services combine trips of multiple customers along similar routes into a single vehicle. The collective dynamics of the fleet of ride-pooling vehicles fundamentally underlies the efficiency of these services. In simplified models, the common features of these dynamics give rise to scaling laws of the efficiency that are valid across a wide range of street networks and demand settings. However, it is unclear how constraints of the vehicle fleet impact such scaling laws. Here, we map the collective dynamics of capacity-constrained ride-pooling fleets to services with unlimited passenger capacity and identify an effective fleet size of available vehicles as the relevant scaling parameter characterizing the dynamics. Exploiting this mapping, we generalize the scaling laws of ride-pooling efficiency to capacity-constrained fleets. We approximate the scaling function with a queueing theoretical analysis of the dynamics in a minimal model system, thereby enabling mean-field predictions of required fleet sizes in more complex settings. These results may help to transfer insights from existing ride-pooling services to new settings or service locations.
k‐sparse signal recovery via unrestricted ℓ1−2$\ell _{1-2}$‐minimization
Authors: Xie Shaohua , Liang Kaihao 
Published: June 2022

AbstractIn the field of compressed sensing, ‐minimization model can recover the sparse signal well. In dealing with the ‐minimization problem, most of the existing literature uses the difference of convex algorithm (DCA) to solve the unrestricted ‐minimization model, that is, model (4). Although experiments have proved that the unrestricted ‐minimization model can recover the original sparse signal, the theoretical proof has not been established yet. This paper mainly proves theoretically that the unrestricted ‐minimization model can recover the sparse signal well, and makes an experimental study on the parameter λ in the unrestricted minimization model. The experimental results show that increasing the size of parameter λ in (4) appropriately can improve the recovery success rate. However, when λ is sufficiently large, increasing λ will not increase the recovery success rate.
Vision‐based edge wave detection for cold‐rolled steel plate using 3D camera
Authors: Zhao Lei , Li Xiaolong , Li Xiaobo 
Published: June 2022

AbstractEdge wave detection is a key technology in steel plate quality inspection, which is beneficial to improve the production quality of steel products and the efficiency of enterprises. In this letter, a novel algorithm based on visual projection and pixel statistics is proposed to detect the edge wave using 3D camera. The proposed algorithm first uses a series of image preprocessing to effectively remove the influence of irrelevant interference, and transforms the colour image into the binary image. Subsequently, three key positions of the edge wave in range image are precisely determined based on visual projection and pixel statistics. Finally, two 3D cameras are used to acquire the range images to evaluate the proposed algorithm's performance. The results show that the proposed algorithm can accurately detect the edge wave instead of human eye detection.
Improved model‐free adaptive predictive control‐based cooperative driving control for connected and automated vehicles subject to time‐varying communication delays and packet losses at signal‐free intersections
Authors: Yu Jie , Jiang Fachao , Luo Yugong , Kong Weiwei 
Published: June 2022

AbstractIn a vehicle‐to‐infrastructure (V2I) communication network at signal‐free intersections, time‐varying delays and random packet losses may occur because of the unreliable nature of wireless communication, which can degrade the performance of cooperative driving for large‐scale connected and automated vehicles (CAVs). Consequently, to solve this problem, this paper proposed a cooperative driving control method based on improved model‐free adaptive predictive control (IMFAPC). I/O data of the target CAVs during driving are adopted to realize the networked predictive control of the time‐varying transmission delays and packet losses in the dynamic linearization prediction scheme and moving horizon prediction control technology. And then the vehicle can be allocated the expected speed to realize accurate vehicle control. In addition, the convergence of the IMFAPC‐based cooperative driving control algorithm is proven by conducting a stability analysis. Extensive numerical experiments verified the effectiveness of the proposed control strategy, and the results demonstrate that the proposed method can alleviate the adverse effects of time‐varying delays and random packet losses on the control effects, thereby improving traffic efficiency under various traffic volumes on the basis of ensuring the safety of multi‐vehicle driving.
Validação de um instrumento simples e de aplicação rápida para rastrear incapacidade em pacientes com hanseníase
Authors: Pinho Adriano Bastos , Freitas Murilo Moraes de , Fontes Cor Jesus Fernandes 
Published: June 2022

Resumo
Objetivo Avaliar um instrumento diagnóstico simples e rápido a ser utilizado por qualquer profissional da saúde para rastrear a incapacidade apresentada por pacientes com hanseníase.
Método Estudo de validação de teste de diagnóstico realizado em uma amostra de 156 pacientes com hanseníase para rastrear incapacidade funcional, por meio do questionário abreviado disabilities of arm, shoulder, and hand (QuickDASH). A avaliação neurológica simplificada proposta pela Organização Mundial da Saúde foi utilizada como referência. Construiu-se a curva de características operacionais do receptor (ROC) para determinação do ponto de corte do QuickDASH que melhor discriminou pacientes com incapacidade funcional provocada pela hanseníase.
Resultados Foram identificados 86 (55,5%) pacientes com incapacidade funcional pela avaliação neurológica simplificada. O desempenho do QuickDASH mostrou que, em ponto de corte de 30 pontos, a sensibilidade e a especificidade foram de 72,1% e 68,1% (acurácia de 70,3%), respectivamente, para identificar incapacidade funcional, com um valor preditivo positivo de 73,8%.
Conclusão O instrumento QuickDASH mostrou boa acurácia para rastrear incapacidade funcional no paciente com hanseníase, podendo ser útil na prática clínica da atenção básica e ambulatorial geral, com o objetivo de identificar pacientes que necessitam de referência especializada para sua prevenção e tratamento.
Liberation from Mechanical Ventilation: Established and New Insights
Authors: Burns Karen E.A. , Agarwal Arnav , Bosma Karen J. , Chaudhuri Dipayan , Girard Timothy D. 
Published: June 2022

AbstractA substantial proportion of critically ill patients require ventilator support with the majority requiring invasive mechanical ventilation. Timely and safe liberation from invasive mechanical ventilation is a critical aspect of patient care in the intensive care unit (ICU) and is a top research priority for patients and clinicians. In this article, we discuss how to (1) identify candidates for liberation from mechanical ventilation, (2) conduct spontaneous breathing trials (SBTs), and (3) optimize patients for liberation from mechanical ventilation. We also discuss the roles for (4) extubation to noninvasive ventilation and (5) newer modes of mechanical ventilation during liberation from mechanical ventilation. We conclude that, though substantial progress has been made in identifying patients who are likely to be liberated (e.g., through the use of SBTs) and management strategies that speed liberation from the ventilator (e.g., protocolized SBTs, lighter sedation, and early mobilization), many important questions regarding liberation from mechanical ventilation in clinical practice remain unanswered.
Long-Term Clinical and Radiologic Outcome Following Surgical Treatment of Lumbar Spondylodiscitis: A Retrospective Bicenter Study
Authors: Sommer Björn , Babbe-Pekol Timo , Feulner Julian , Richter Richard Heinrich , Buchfelder Michael , Shiban Ehab , Sesselmann Stefan , Forst Raimund , Wiendieck Kurt 
Published: June 2022

Abstract
Background and Study Aims Spinal instrumentation for spondylodiskitis (SD) remains highly controversial. To date, surgical data are limited to relatively small case series with short-term follow-up data. In this study, we wanted to elucidate the biomechanical, surgical, and neurologic long-term outcomes in these patients.
Material and Methods A retrospective analysis from two German primary care hospitals over a 9-year period (2005–2014) was performed. The inclusion criteria were (1) pyogenic lumbar SD, (2) minimum follow-up of 1 year, and (3) surgical instrumentation. The clinical and radiologic outcome was assessed before surgery, at discharge, and at a minimum of 12 months of follow-up. Follow-up included physical examination, laboratory results, CT and MRI scans, as well as assessment of quality of life (QoL) using short-form health survey (SF-36) inventory, Oswestry Disability Questionnaire, and visual analog scale (VAS) spine score.
Results Complete data were available in 70 patients (49 males and 21 females, with an age range of 67±12.3 years) with a median follow-up of 6.6 ± 4.2 years. Follow-up data were available in 70 patients after 1 year, in 58 patients after 2 years, and in 44 patients after 6 years. Thirty-five patients underwent posterior stabilization and decompression alone and 35 patients were operated on in a two-stage 360-degree interbody fusion with decompression. Pre- and postoperative angles of the affected motion segment were 17.6 ± 10.2 and 16.1 ± 10.7 degrees in patients with posterior instrumentation only and 21.0 ± 10.2 and 18.3 ± 10.5 degrees in patients with combined anterior/posterior fusion. Vertebral body subsidence was seen in 12 and 6 cases following posterior instrumentation and 360-degree instrumentation, respectively. Nonfusion was encountered in 22 and 11 cases following posterior instrumentation and 360-degree instrumentation, respectively. The length of hospital stay was 35.0 ± 24.5 days. Surgery-associated complication rate was 18% (12/70). New neurologic symptoms occurred in 7% (5/70). Revision surgery was performed in 3% (2/70) due to screw misplacement/hardware failure and in 3% (2/70) due to intraspinal hematoma. Although patients reported a highly impaired pain deception and vitality, physical mobility was unaffected and pain disability during daily activities was moderate.
Conclusion Surgical treatment of SD with a staged surgical approach (if needed) is safe and provides very good long-term clinical and radiologic outcome.
Análise epidemiológica de 245 pacientes com pubalgia atlética
Authors: Goes Rodrigo Araujo , Teles Fernando Delgado Carlos , Figueiredo Felipe , Noronha Diogo Ramos , Coelho Olivia Nogueira , Peixoto Lourenço Pinto 
Published: June 2022

Resumo
Objetivo Analisar as características clínico-epidemiológicas da pubalgia do atleta, e definir o perfil epidemiológico dos pacientes com queixa de dor na região baixa do abdômen e virilha avaliados em um centro especializado.
Metodologia Realizou-se um estudo retrospectivo de uma série de casos, no qual se avaliou o perfil epidemiológico de 245 pacientes esportistas com pubalgia, registrados em prontuário, entre outubro de 2015 e fevereiro de 2018. A amostra selecionada foi submetida a uma avaliação clínica, e os resultados foram documentados a partir da aplicação de um questionário.
Resultados A amostra estudada foi de 245 pacientes com idades que variavam entre 14 e 75 anos. O futebol e a corrida foram os esportes mais prevalentes, e 58% treinavam ou praticavam esporte 3 ou mais dias por semana. Após a avaliação dos movimentos esportivos específicos, foi observada piora dos sintomas em 24% com a troca de direção; em 23%, nos chutes; em 22%, nos sprints e treinos de velocidade; em 17%, nas corridas longas; e em 14%, nos saltos. Dor durante o ato sexual foi relatado em 13% dos pacientes. A maior parte dos pacientes (80%) relatou que a região inguinal, os adutores e o púbis (linha média) eram os principais sítios da dor. O teste de contração dos adutores contra resistência com joelho em extensão foi positivo em 77,6% dos pacientes avaliados, e o teste de Flexão simultânea do Quadril + Abdômen contra resistência foi positivo em 76.7% dos pacientes.
Conclusão O presente estudo demonstrou o predomínio dessa lesão nos pacientes do sexo masculino praticantes de futebol e de corrida. A dor, na maioria dos casos (80%), estava presente na região inguinal, nos adutores e no púbis. A maioria dos pacientes demorou mais de seis meses para ter o diagnóstico clínico confirmado.