bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication of porous gehlenite coating on Al2O3–ZrO2–SiC composite ceramics and its in vitro biological activities
Authors: Chen Xianzhi , Li Jiaxin , Gu Shuidan , Wu Zhiyu , Wen Feng , Luo Lijie , Li Jianbao , Chen Yongjun 
Published: March 2022

Porous gehlenite coatings on Al2O3–ZrO2–SiC composite ceramics were prepared by electro-spraying technique combined with reactive sintering method. The influences of gehlenite coating on the mechanical property of the ceramics and biological activity of the coating were investigated. The results indicated that the gehlenite coating has limited influences on flexural strength and fracture toughness of the ceramics, and the coating has elastic modulus of 82 GPa, hardness of 2.2 GPa, and adhesive strength of 1512 mN, suggesting its potential application in load-bearing ceramic implants. Simulated body fluid soaking test, CCK-8 and alkaline phosphatase activity assay demonstrated that the porous gehlenite coating has strong mineralization ability, which promotes proliferation and differentiation of MC3T3-E1 cells. These excellent biological performances can be attributed to the synergistic effect of the porous surface of the coating and its release of Ca2+ and Si4+.
Incidence of Hypotension Associated With Two Different Vasopressin Discontinuation Strategies in the Recovery Phase of Septic Shock
Authors: Murata Joseph , Buckley Mitchell , Lehn Julie , Agarwal Sumit K. , Stevenson Byron , Martinez Brandon , MacLaren Robert 
Published: March 2022

Introduction: Safe and effective vasopressor withdrawal strategies during the recovery phase of septic shock lack consensus and are not addressed in clinical practice guidelines. The purpose of this study was to compare the incidence of clinically relevant hypotension associated with different vasopressin (AVP) discontinuation strategies. Methods: This was a single-center, retrospective, cohort study, conducted at a university medical center over a three-year period. Adult patients ≥18 years with septic shock were included in the study. Patients were stratified into two groups; patients incrementally weaned from AVP and patients in which AVP was abruptly discontinued. The primary endpoint was to compare the incidence of clinically relevant hypotension between study groups up to 24 hours following discontinuation. Secondary analyses included the incidence of any hypotensive event up to 24 hours after AVP cessation, intensive care unit and hospital length of stay, and in-hospital mortality. Results: A total of 74 patients (n = 46 AVP wean and n = 28 AVP no-wean) met inclusion criteria and were included in the study. The primary outcome was not statistically different between groups. Clinically relevant hypotension occurred in 24 patients (52.3%) and 16 patients (57.1%) in the AVP wean and AVP no-wean groups, respectively (P = .68). There were no significant differences in any secondary clinical outcome between the two study groups. Conclusion: No differences were found in the incidence of clinically relevant hypotension, length of stay, or mortality between AVP weaning and no-weaning discontinuation strategies. These findings suggest incremental weaning and abrupt withdrawal of AVP are both acceptable discontinuation strategies.
Experimental investigation on mechanical behavior of fiber–metal laminates reinforced by hybrid carbon nanotubes and nanosilica under quasi-static pressure load
Authors: Saleh M. , Tooski M. Yarmohammad , Khorshidvand A. R. , Javadi M. 
Published: March 2022

In this study, the effect of carbon nanotubes (CNT) and silica nanoparticles on quasi-static behavior of fiber–metal laminates (FML) has been experimentally scrutinized. FML consists of two layers of aluminum alloy plates and four composite layers including CNT/nanosilica-reinforced epoxy resin and glass fibers. The effect of weight percentage of carbon nanotube and nanosilica incorporated and their weight ratio in resin epoxy on the performance of FMLs against quasi-static compressive load has been considered. Furthermore, the design of experiments method and response surface methodology have been put into practice to develop an accurate mathematical relationship between the input parameters and the response variable. After designing and performing the experiments based on analysis of variance, a mathematical model corresponding to the real process is obtained. Moreover, the presented model has been validated by statistical methods. The results of this study indicate that the energy absorption capacity of these materials significantly increase through adding CNT to the FML, the highest failure force of 11.64 kN was obtained for FLMs comprising 0.6 wt.% of CNT and 3 wt.% of SiO2. An improvement of 27.88% and 45.86% in the absorbed energy and failure force was achieved, respectively, by adding 3 wt.% of SiO2 and 0.6 wt.% of CNT to FLM compared to pristine FLM.
Carrydown of liquid friction modifier
Authors: Rahmani Hatef , Gutsulyak Dmitry , Stanlake Louisa , Stoeber Boris , Green Sheldon 
Published: March 2022

A small-scale laboratory apparatus was built to study liquid friction modifier (LFM) behavior in a top-of-rail application. A field experiment was also carried out to complement the laboratory findings. KELTRACK® (a water-based LFM) was used as the test fluid. Laser-induced fluorescence served to measure the LFM thickness left on the track after the passage of the wheel. The lab experiments show that the LFM cannot withstand the high wheel-rail contact pressure in the nip present in cargo rail situations. As a result, the liquid is squeezed out laterally and attaches to the edges of the wheel contact band. This “edge liquid” is then carried down the track on the wheel. Gravimetric measurements of the wheel contact band confirm this observation, and show that only a minute amount of liquid is carried through the nip in the valleys between surface roughness features. In the field experiment, the LFM is applied from a trackside unit on a tangent section of the track. About 500 m downstream of the application point, the track has a curved section. LFM cannot be detected anywhere on the track a short distance (∼200 m) past the application unit. However, LFM is detectable on the curved sections of the track up to approximately 2 km from the application unit. This LFM on the curved track is believed to be due to transfer of the “edge liquid” from the wheel to the track, caused by the movement of the contact band as the train rounds a curve. The presence of LFM on the curved track far downstream is consistent with prior measurements of reduced lateral force on the curved track downstream of LFM application sites.
Hydroxychloroquine increased cholesterol transfer to high-density lipoprotein in systemic lupus erythematosus: A possible mechanism for the reversal of atherosclerosis in the disease
Authors: Lang Maria G , Vinagre Carmen GC , Bonfa Eloisa , Freitas Fatima R , Pasoto Sandra G , Brito Tatiane S , Seguro Luciana PC , Maranhão Raul C , Borba Eduardo F 
Published: March 2022

Introduction The beneficial effect of hydroxychloroquine (HCQ) in decreasing LDL levels on Systemic Lupus Erythematosus (SLE) is well defined. The influence of this drug on HDL levels is still under debate and information about its effect on cholesterol reverse transport is lacking. Objective To evaluate the effects of HCQ on HDL levels and the transfer of lipids to this lipoprotein in SLE. Methods Nineteen SLE patients using only HCQ (SLE WITH HCQ), 19 SLE patients without any therapy (SLE WITHOUT THERAPY), and 19 healthy controls (CONTROL) were included. All three groups were premenopausal women age- and gender-matched. Serum lipids and apolipoproteins were determined by commercial kits. An in vitro transfer of four lipids (14C-Phospolipid, 3H-Cholesteryl ester, 3H-Triglyceride, and 14C-Unesterified cholesterol) from a radioactively labeled nanoemulsion donor to HDL was performed in all participants. Results Groups had comparable mean age, weight, height, BMI(body mass index), and waist circumference ( p > .05). Mean HDL levels were higher in SLE WITH HCQ group compared to SLE WITHOUT THERAPY(58.37 ± 14.04 vs 49.79 ± 8.0 mg/dL; p < .05) but lower than CONTROL (58.37 ± 14.04 vs 68.58 ± 9.99 mg/dL; p < .05). Total cholesterol (TC) and LDL levels were also significantly lower in SLE WITH HCQ compared SLE WITHOUT THERAPY(148.16 ± 16.43 vs 167.11 ± 30.18 mg/dL; p < .05, 75.05 ± 22.52 vs 96.05 ± 25.63 mg/dL; p < .05) and CONTROL (148.16 ± 16.43 vs 174.11 ± 23.70 mg/dL; p < .05, 75.05 ± 22.52 vs 88.53 ± 20.24 mg/dL; p < .05). The in vitro lipid transfer to HDL study revealed a significant difference among the three groups ( p = .002) with a higher transfer of unesterified cholesterol(UC) in SLE WITH HCQ compared to SLE WITHOUT THERAPY(5.40 ± 1.05% vs. 4.44 ± 1.05%; p < .05). The latter was significantly decreased compared to CONTROL (5.40 ± 1.05% vs. 5.99 ± 1.71%; p < .05).The percentages of transfer of triacylglycerol (4.93 ± 0.69% vs. 4.50 ± 0.69% vs. 5.14 ± 1.01%; p = .054), esterified cholesterol (5.24 ± 0.70% vs. 4.96 ± 0.89% vs. 5.69 ± 1.27%; p = .079), and phospholipid (15.67 ± 1.03% vs. 15.34 ± 1.44% vs. 16.47 ± 1.89%; p = .066) were similar among groups. Conclusion The present study is the first to demonstrate that HCQ promoted a higher transfer of unesterified cholesterol which may account for the increased HDL levels in lupus patients under HCQ. This desirable effect may underlie the reported reduced atherosclerosis in SLE.
Outcomes of a co-located approach for metabolic health care for people with schizophrenia
Authors: Siskind Dan , Yen Wesley , Thuzar Moe , Russell Anthony , Warren Nicola , Kisely Steve , Kar Ray Manaan , Motamarri Balaji 
Published: March 2022

Objective Metabolic syndrome is highly prevalent among people with schizophrenia. This study aims to assess the impact on metabolic and attendance outcomes of a co-located, dedicated, endocrinologist-led metabolic clinic in a stand-alone public community mental health service. Methods Demographic and metabolic data on the first 48 consecutive referrals over a 12-month period were retrospectively collected and analysed. Attendance rates at the co-located clinic were compared to the general hospital obesity and diabetes clinics. Results Clinic attendees had significant reductions in triglycerides and total cholesterol, but not mean weight, BMI, waist circumference, blood pressure or HbA1c. Attendance rates were significantly higher in the co-located clinic compared to the general hospital obesity and diabetes clinics for both initial consult (80.0% vs 51.2%, p < 0.001) and review appointment (64.3% vs 47.6%, p < 0.001). Conclusion The co-location of a specialist metabolic clinic within a mental health service resulted in enhanced engagement and improvement of metabolic health in people with schizophrenia.
Outcomes of telemedicine care during the COVID-19 pandemic: Experience from an intervention program designed for vulnerable population in Brazil
Authors: Carneiro Ana Carolina , de Pinho Guilherme S , Belo José Victor , Bolonhini Sabine , Carneiro Neto Manuel B , Mallet Toueg Adriana , Fernandes Arthur Gustavo 
Published: March 2022

Purpose Telehealth plays an important role on the combat of COVID-19. In this context, the SAS Brasil telemedicine program became a viable option in Brazil, where the population faced challenging access to healthcare services during the pandemics. In this study, we describe the sociodemographic profile, reasons for enrollment, outcomes of consultation, and satisfaction of participants who received telemedicine consultations through the SAS program. Methods A retrospective cross-sectional study was conducted with data from the SAS Telemedicine program including consultations performed from July 15, 2020, to April 15, 2021. The study describes the SAS Brasil experience and data collected in the period. Patients’ satisfaction perception was evaluated through the Net Promoter Score (NPS). Results A total of 6490 participants were evaluated, 69.5% of them were female and 40.8% with age from 21 to 40 years. In the period, 22,664 teleconsultations were performed, mainly due to Mental health (40.4%), Respiratory (35.8%), and Nutritional (4.5%) disorders. Out of the 6312 patients with a defined outcome along the period, 96.0% were discharged and 4.0% were referred to presential care. The calculated NPS was + 95.77 and most patients answered that they would use the service again if needed (99.21%) and had their issue resolved (89.76%). Conclusion During the period of the COVID-19 pandemic, telehealth has been consolidated as a tool that offers access to specialized healthcare with wide acceptance by users and can be implemented in populations in vulnerability situations.
Connecting over the internet: Establishing the therapeutic alliance in an internet-based treatment for depressed adolescents
Authors: Mortimer Rose , Somerville Matthew P. , Mechler Jakob , Lindqvist Karin , Leibovich Liat , Guerrero-Tates Brenda , Edbrooke-Childs Julian , Martin Peter , Midgley Nick 
Published: March 2022

Internet-based treatments have been developed for youth mental health difficulties, with promising results. However, little is known about the features of therapeutic alliance, and how it is established and maintained, in text-based interactions between adolescents and therapists in internet-based treatments. This study uses data collected during a pilot evaluation of a psychodynamic internet-based therapy for depressed adolescents. The adolescents had instant-messaging chats with their therapists once a week, over 10 weeks. The adolescents also rated the therapeutic alliance each week, using the Session Alliance Inventory. The present study uses qualitative methods to analyse transcripts of text-based communication between the young people and their therapists. The aim is to identify and describe the key features of therapeutic alliance, and reflect upon the implications for theory and clinical practice. Analysis identified three ‘values’ that may underpin a strong therapeutic alliance: togetherness, agency and hope. A number of therapist techniques were also found, which seemed to create a sense of these values during text-chat sessions. These findings are discussed, alongside implications for future research.
The Cultural Formulation Interview—Generating distance or alliance? A qualitative study of practice changes in Danish mental healthcare
Authors: Lindberg Laura Glahder , Carlsson Jessica , Kristiansen Maria , Skammeritz Signe , Johansen Katrine Schepelern 
Published: March 2022

This article presents provider experiences with the Cultural Formulation Interview (CFI) in Danish mental healthcare for migrant patients. Semi-structured interviews with 17 providers and 20 recorded CFI sessions were analyzed with a constructivist grounded theory approach. Based on our empirical material, we endorse the CFI’s ability to facilitate working alliance and a profound and contextually situated understanding of the patient. Further, the CFI supported less-experienced providers in investigating cultural issues. Conversely, we found that CFI questions about cultural identity and background evoked notions of distance and ‘othering’ in the encounter. Nine providers had felt discomfort and professional insecurity when the CFI compelled them to introduce explanatory frameworks of culture in the mental health assessment. Eleven providers had experienced that the abstract nature of the questions inhibited patient responses or led to short and stereotypical descriptions, which had limited analytical value. We describe the contradictory CFI experiences of alliance versus distance at three levels: 1) at the CFI instrument level; 2) at the organizational level; and 3) at the contextual and structural level. We demonstrate benefits and pitfalls of using the CFI with migrants in Denmark, which is an example of a European healthcare context where cultural consultation is not an integrated concept in health education programs and where the notion of culture is contentious due to negative political rhetoric on multiculturalism. We suggest that the CFI should be introduced with thorough training; focus on fidelity; and supervision in the clinical application and understanding of the concept of culture.
Triaxial strength and failure criterion of ultra-high performance concrete
Authors: Wu Pengtao , Wu Chengqing , Liu Zhongxian , Xu Shenchun , Li Jun , Li Jie 
Published: March 2022

Over the past few decades, ultra-high performance concrete (UHPC) has been widely studied and applied because of its outstanding mechanical properties. A large number of studies have been conducted on the uniaxial static and dynamic performance of UHPC materials, however, limited investigations exist on the triaxial compression properties of UHPC. In this study, 98 cylindrical samples of UHPC with different steel fiber volumetric ratios (0.0%–1.5%) were tested to investigate the triaxial behavior of UHPC under different confining pressures (0 MPa–40 MPa). The confining pressure and steel fiber contents have clear impact on the triaxial strength, failure mode, crack width, and the angle between the oblique crack and the axial direction. The triaxial compressive strength and compressive toughness of UHPC subjected to various confining pressures are obtained from the tests and discussed in the study. Based on the testing data, the triaxial compression failure criterion of UHPC is established according to the unified strength theory. Finally, the simplified empirical equations for the full stress-strain curves of UHPC specimens subjected to uniaxial and multiaxial loads are derived, and good agreement with the experimental results is achieved.
Factors that contribute to strong working alliances between case managers and clients
Authors: Cheng Tyrone C , Lo Celia C 
Published: March 2022

Summary Published literature has demonstrated that strong case manager–client working alliances foster improvement among clients. Reflecting a case-management context, this study explored how working alliances, as perceived by clients, are related to interpersonal capacities (or social support); intrapersonal dynamics; severity of problems facing client; and other client and case manager characteristics. The study included 101 clients and their 26 case managers at four nonprofit social-service agencies. Findings Working alliances, as perceived by clients, were observed to be associated positively with 3 variables: working alliance as viewed by case manager, length of time client worked with case manager, and client female gender. In turn, client mental-health or substance-use problem was linked to client unfavorable perception of working alliance. No link was observed between client perception of alliance and 6 variables: client social support, goal achievement, problem severity, client–case manager shared ethnicity, case manager work experience, and client age. Applications The findings suggest that working alliance is collaborative and interactive throughout the helping process. This impacts social work training protocols. Case managers who must establish working alliances with clients need the relevant collaboration skills, which may need to be introduced and practiced at in-service meetings or workshops.
The Impact of Artificial Intelligence on Expertise Development: Implications for HRD
Authors: Ardichvili Alexandre 
Published: March 2022

Problem The implementation of artificial intelligence (AI) is assumed to lead to increased productivity of knowledge workers. However, AI could also have negative effects on the development of professional expertise. Solution A review of the literature on expertise development is provided, followed by examples of AI implementation in a knowledge-intensive profession, accounting. The analysis of these examples suggests that automation can result in the loss of expertise due to reduced opportunities for learning from deliberate practice and experienced colleagues, and from working on progressively more complex tasks. Implications for human resource development (HRD) include creating alternative individual development opportunities and promoting organizational cultures conducive to expertise development in human-machine interaction modes. Stakeholders The results of this study will be of interest to scholars of HRD, accounting education, and human-machine interaction. Practical implications will be of relevance to HRD professionals and managers responsible for the implementation of artificial intelligence solutions.
Carotid artery stenting prior to coronary artery bypass grafting in patients with carotid stenosis: Clinical outcomes
Authors: Mohammadian Reza , Tarighatnia Ali , Sharifipour Ehsan , Nourizadeh Eskandar , Parvizi Rezayat , Applegate Camille T. , Nader Nader D. 
Published: March 2022

Objectives Management of patients undergoing coronary artery bypass grafting (CABG) with obstructive disease of the carotid arteries is still a matter of debate. We compared the results of staged carotid artery stenting (CAS) before CABG in patients with carotid lesions. Materials and Method Patients with significant carotid artery disease who were deemed to simultaneously suffer from an obstructive coronary artery disease requiring CABG from 2008 to 2018 were screened and enrolled in this study. We performed a staged CAS in cases with ≥60% stenosis and neurological symptoms or asymptomatic patients with ≥80% carotid artery stenosis. Patients with bilateral carotid lesions received sequential CAS within three weeks. Six weeks after the CAS procedure, all patients underwent CABG. Results A total of 142 patients were included. Eighty-five of these had neurological symptoms, while the remaining 40% were asymptomatic. Thirty-one patients underwent sequential CAS for bilateral lesions. The cerebrovascular event (CVE) following CAS (3 patients) and CABG (3 patients) was 4.2%. There was only a single case of mortality in this cohort. Although it was not statistically significant, CVE after CABG was more frequent in patients with bilateral carotid disease. Conclusions Our results showed that staged CAS could be performed with minimal adverse outcomes in patients suffering from a simultaneous occlusive disease of carotids and coronary arteries before CABG. Bilateral CAS will further decrease cerebrovascular events and could be performed consequently or concomitantly.