bluuebunny/crossref_metadata_2025_split huggingface dataset:
Destinations and Data State-of-the-Art in Switzerland and Liechtenstein
Authors: Garbani-Nerini Elide , Marchiori Elena , Cantoni Lorenzo 
Published: January 2022

AbstractThis research investigates the state of the art among Switzerland (CH)’s and Liechtenstein (FL)’s destinations, intended here as Destination Marketing Organizations (DMOs), when it comes to their relationship with data: what data are collected, how they are stored, analyzed and what impact they have on the destination. This study aims at bringing insights into smart tourism studies as a key aspect of the debate is how DMOs deal with data. Based on a survey performed with CH’s and FL’s DMOs and related stakeholders, results suggested that there are common conceptual nodes shared by practitioners when it comes to defining smart destinations. However, when it comes to data-related practices (data collection, storage, analysis and sharing) DMOs have very different processes in place. There are organizations that collect but do not extensively analyze data, while others are still not so keen on sharing their data with the whole destination ecosystem. Furthermore, organizations’ decision-making processes appear to be based to some extent on data, especially when it comes to (digital) marketing initiatives and campaigns, although behaviors are quite different also in this area. Destination managers might benefit from this paper as the study shows how to investigate data-related practices of an organization. This type of analysis could allow an assessment of the situation and an understanding of the direction in which the organization might move forward.
Identifying the Elements of Great Online Customer Encounters
Authors: Heinonen Johanna , Pesonen Juho 
Published: January 2022

AbstractCustomer service is a major factor in the success of digital marketing. This study examines the service encounters between tourists and service providers, in this case, Visit Helsinki. The goal is to understand what are the dimensions of service quality in online chat discussions between tourists and DMO personnel and what elements in these discussions support the co-creation of great customer experiences. Altogether 123 chat discussions in June 2020 were downloaded and analysed using qualitative content analysis and statistical tests. The results show that great customer experiences are the result of extensive effort from the customer service agents where they go beyond just providing a satisfactory solution for the customer. The results are managerially important for destinations and tourism businesses around the world and increase the theoretical understanding of the moment of truth concept and its different elements in online service encounters.
Window to the Destination: Tourists’ Local Experience via “Online Experiences” on Airbnb Amid the Pandemic
Authors: Zhang Junjiao , Qiu Hanqin 
Published: January 2022

AbstractThis study aims to explore the composition of virtual guided tour experience on Airbnb and to develop a formation process of virtual guided tour experience. A case study based on the qualitative analysis was conducted with a dataset of online reviews towards an Online Experience in Beijing, China. A three-stage process of virtual guided tour experience was concluded, including experience encounter, experience evaluation, and behavioral intention. Experience encounter describes the experience composition from four dimensions: interpretation quality, host credibility, tourist-host social contact, and peer interaction; Experience evaluation is involved with benefits mainly gained from the enhanced understanding of local culture and the satisfaction attributed by the sense of telepresence; Further, behavioral intention covers both online and offline willingness to recommend or repurchase the virtual tour, or visit the destination in person after the pandemic. Theoretical and practical implications in navigating tourism recovery were discussed.
Visualizing and Comparing Online Travel Reviews of the Great Walls: A Data Mining Approach
Authors: Ling Jin , Sorokina Nadezda 
Published: January 2022

AbstractThis research employs two samples of heritage sites of the Great Wall of China (Ba daling Great Wall and Mu tianyu Great Wall) and their 21000 reviews on TripAdvisor to visualize and induce feature-related comparisons. Word2vec and D3.js are applied for statistical computing and graphing Minimal Spanning Tree (MST) and ThemeRiver. The applications of MST and ThemeRiver are used to delineate outstanding features and clearer feature relationships. In terms of methodology, we applied an innovative research route to combine MST with ThemeRiver to visualize travellers’ online comments. At the same time, the visual results obtained are combined with qualitative analysis to generate valuable, intuitive summaries that can be used for reference in future research. Practically, the results disclose that although both sites are highly enjoyed by tourists, they are significantly different in terms of service, infrastructure and scenery. This article has implications for policymakers and practitioners with regard to making use of online reviews to gather authentic visitor comments on the Great Wall.
Emergence and Rapid Popularization of Paid Web-Conferencing-Application-Based Tours in Japan: An Analysis of Their Business Potential
Authors: Hori Kennichiro , Yoshida Ibuki , Suzuki Miki , Yiwen Zhu , Kurata Yohei 
Published: January 2022

AbstractFollowing the emergence of COVID-19 pandemic, people in Japan were asked to refrain from traveling, resulting in various companies coming up with new ways of experiencing tourism. Among them, the online tourism experience of H.I.S. Co., Ltd. (HIS) drew more than 100,000 participants as of August 29, 2021. In this study, we focused on an online tour where the host goes to the site and records real time communication using a web conference application. The destinations of online tours were analyzed through text mining, and the characteristics of online tours were analyzed using Latent Dirichlet Allocation (LDA) of topic models. The results show that the number of online tours is weakly negatively correlated with distance and time differences. From the topic model, it is evident that the guide is important in online tours. In addition, the sense of presence, communication environment, and images, which are considered to be unique topics in online tours, are also relevant to the evaluation.
New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations
Authors: Herrera-Hernández María Guadalupe , Razzaghi Neda , Fernandez-Gonzalez Pol , Bosch-Presegué Laia , Vila-Julià Guillem , Pérez Juan Jesús , Garriga Pere 
Published: January 2022

AbstractMutations in the photoreceptor protein rhodopsin are known as one of the leading causes of retinal degeneration in humans. Two rhodopsin mutations, Y102H and I307N, obtained in chemically mutagenized mice, are currently the subject of increased interest as relevant models for studying the process of retinal degeneration in humans. Here, we report on the biochemical and functional characterization of the structural and functional alterations of these two rhodopsin mutants and we compare them with the G90V mutant previously analyzed, as a basis for a better understanding of in vivo studies. This mechanistic knowledge is fundamental to use it for developing novel therapeutic approaches for the treatment of inherited retinal degeneration in retinitis pigmentosa. We find that Y102H and I307N mutations affect the inactive–active equilibrium of the receptor. In this regard, the mutations reduce the stability of the inactive conformation but increase the stability of the active conformation. Furthermore, the initial rate of the functional activation of transducin, by the I307N mutant is reduced, but its kinetic profile shows an unusual increase with time suggesting a profound effect on the signal transduction process. This latter effect can be associated with a change in the flexibility of helix 7 and an indirect effect of the mutation on helix 8 and the C-terminal tail of rhodopsin, whose potential role in the functional activation of the receptor has been usually underestimated. In the case of the Y102H mutant, the observed changes can be associated with conformational alterations affecting the folding of the rhodopsin intradiscal domain, and its presumed involvement in the retinal binding process by the receptor.
The basepoint-freeness threshold of a very general abelian surface
Authors: Rojas Andrés 
Published: January 2022

AbstractFor abelian surfaces of Picard rank 1, we perform explicit computations of the cohomological rank functions of the ideal sheaf of one point, and in particular of the basepoint-freeness threshold. Our main tool is the relation between cohomological rank functions and Bridgeland stability. In virtue of recent results of Caucci and Ito, these computations provide new information on the syzygies of polarized abelian surfaces.
Immunhistochemische Analyse einer Hypoxie-assoziierten Signatur in Melanomen mit positivem und negativem Schildwächterlymphknoten
Authors: Toberer Ferdinand , Winkler Julia K. , Haenssle Holger A. , Heinzel-Gutenbrunner Monika , Enk Alexander , Hartschuh Wolfgang , Helmbold Peter , Kutzner Heinz 
Published: January 2022

ZusammenfassungMetabolische Anpassungsprozesse, vermittelt durch sog. Hypoxie-induzierbare Faktoren und deren Zielgene, spielen in zahlreichen Malignomen eine wichtige Rolle. Rasch wachsende Tumoren können ihre Stoffwechselvorgänge an eine auftretende Hypoxie anpassen. So werden beispielsweise nach der Aktivierung des „Hypoxia inducible-factors-1α“ Modifikationen am Glukosestoffwechsel, der intrazellulären pH-Regulation oder der Angiogenese initiiert. In dieser immunhistochemischen Pilotstudie analysierten wir primär kutane Melanome mit positivem und negativem Schildwächterlymphknotenstatus im Hinblick auf mögliche Unterschiede ihrer metabolischen Signatur. Hierbei konnten wir unter anderem zeigen, dass die Expression von Glukosetransporter‑1 (GLUT-1) sowohl in allen Melanomen ohne Subgruppenanalyse, als auch in der Subgruppe mit negativem Schildwächterlymphknoten positiv mit der Tumordicke sowie dem Vorliegen einer Ulzeration korrelierte. Zudem korrelierte bei Melanomen mit positivem Schildwächterlymphknoten die Expression von vaskulärem endothelialem Wachstumsfaktor (VEGF) positiv mit dem Vorliegen einer Ulzeration.
Social assimilation and immigrants’ labour market outcomes
Authors: Piracha Matloob , Tani Massimiliano , Cheng Zhiming , Wang Ben Zhe 
Published: January 2022

AbstractWe analyse how immigrants’ level of social assimilation is related to their labour market outcomes. More precisely, we estimate the association between assimilation and employment, wages, underemployment, three measures of job satisfaction, overeducation and wages. Using Australian longitudinal data, we find that assimilation is strongly associated with employment and wages as well as a number of job satisfaction measures. We then split our data and repeat the analysis for before and after the financial crisis of 2008–2009. We find important differences in the way assimilation is associated with different measures of labour market outcomes under different economic conditions. Finally, we explore mechanisms that may underlie the results.
Context awareness in process monitoring of additive manufacturing using a digital twin
Authors: Reisch Raven T. , Hauser Tobias , Lutz Benjamin , Tsakpinis Alexandros , Winter Dominik , Kamps Tobias , Knoll Alois 
Published: January 2022

AbstractWire Arc Additive Manufacturing allows the cost-effective manufacturing of customized, large-scale metal parts. As the post-process quality assurance of large parts is costly and time-consuming, process monitoring is inevitable. In the present study, a context-aware monitoring solution was investigated by integrating machine, temporal, and spatial context in the data analysis. By analyzing the voltage patterns of each cycle in the oscillating cold metal transfer process with a deep neural network, temporal context was included. Spatial context awareness was enabled by building a digital twin of the manufactured part using an Octree as spatial indexing data structure. By means of the spatial context awareness, two quality metrics—the defect expansion and the local anomaly density—were introduced. The defect expansion was tracked in-process by assigning detected defects to the same defect cluster in case of spatial correlation. The local anomaly density was derived by defining a spherical region of interest which enabled the detection of aggregations of anomalies. By means of the context aware monitoring system, defects were detected in-process with a higher sensitivity as common defect detectors for welding applications, showing less false-positives and false-negatives. A quantitative evaluation of defect expansion and densities of various defect types such as pore nests was enabled.
p-Hyperbolicity of homotopy groups via K-theory
Authors: Boyde Guy 
Published: January 2022

AbstractWe show that $$S^n \vee S^m$$

S
n

∨

S
m

is $${\mathbb {Z}}/p^r$$

Z
/

p
r

-hyperbolic for all primes p and all $$r \in {\mathbb {Z}}^+$$

r
∈

Z

+

, provided $$n,m \ge 2$$

n
,
m
≥
2

, and consequently that various spaces containing $$S^n \vee S^m$$

S
n

∨

S
m

as a p-local retract are $${\mathbb {Z}}/p^r$$

Z
/

p
r

-hyperbolic. We then give a K-theory criterion for a suspension $$\Sigma X$$

Σ
X

to be p-hyperbolic, and use it to deduce that the suspension of a complex Grassmannian $$\Sigma Gr_{k,n}$$

Σ
G

r

k
,
n

is p-hyperbolic for all odd primes p when $$n \ge 3$$

n
≥
3

and $$0<k<n$$

0
<
k
<
n

. We obtain similar results for some related spaces.
Understanding gluten-free bread ingredients during ohmic heating: function, effect and potential application for breadmaking
Authors: Waziiroh Elok , Schoenlechner Regine , Jaeger Henry , Brusadelli Gloria , Bender Denisse 
Published: January 2022

AbstractDue to the absence of gluten, several challenges arise during gluten-free (GF) bread baking, affecting the mid-and-end-product quality. The main approach to overcome this issue is to combine certain functional ingredients and additives, to partially simulate wheat bread properties. In addition, the optimization of the baking process may contribute to improved product quality. A recent and very promising alternative to conventional baking is the use of ohmic heating (OH). Due to its volumetric and uniform heating principle, crumb development during baking and consequently bread volume is improved, which enhances the overall GF bread quality. Depending on the GF formulation, critical factors such as the electrical conductivity and viscosity of the batter may vary, which have a significant effect on the OH process performance. Therefore, this review attempts to provide a deeper understanding of the functionality of GF bread ingredients and how these may affect critical parameters during the OH processing.
Chewing gum reduces visually induced motion sickness
Authors: Kaufeld Mara , De Coninck Katharina , Schmidt Jennifer , Hecht Heiko 
Published: January 2022

AbstractVisually induced motion sickness (VIMS) is a common side-effect of exposure to virtual reality (VR). Its unpleasant symptoms may limit the acceptance of VR technologies for training or clinical purposes. Mechanical stimulation of the mastoid and diverting attention to pleasant stimuli-like odors or music have been found to ameliorate VIMS. Chewing gum combines both in an easy-to-administer fashion and should thus be an effective countermeasure against VIMS. Our study investigated whether gustatory-motor stimulation by chewing gum leads to a reduction of VIMS symptoms. 77 subjects were assigned to three experimental groups (control, peppermint gum, and ginger gum) and completed a 15-min virtual helicopter flight, using a VR head-mounted display. Before and after VR exposure, we assessed VIMS with the Simulator Sickness Questionnaire (SSQ), and during the virtual flight once every minute with the Fast Motion Sickness Scale (FMS). Chewing gum (peppermint gum:M = 2.44, SD = 2.67; ginger gum:M = 2.57, SD = 3.30) reduced the peak FMS scores by 2.05 (SE = 0.76) points as compared with the control group (M = 4.56, SD = 3.52),p < 0.01,d = 0.65. Additionally, taste ratings correlated slightly negatively with both the SSQ and the peak FMS scores, suggesting that pleasant taste of the chewing gum is associated with less VIMS. Thus, chewing gum may be useful as an affordable, accepted, and easy-to-access way to mitigate VIMS in numerous applications like education or training. Possible mechanisms behind the effect are discussed.
Management of herpesvirus reactivations in patients with solid tumours and hematologic malignancies: update of the Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO) on herpes simplex virus type 1, herpes simplex virus type 2, and varicella zoster virus
Authors: Henze Larissa , Buhl Christoph , Sandherr Michael , Cornely Oliver A. , Heinz Werner J. , Khodamoradi Yascha , Kiderlen Til Ramon , Koehler Philipp , Seidler Alrun , Sprute Rosanne , Schmidt-Hieber Martin , von Lilienfeld-Toal Marie 
Published: January 2022

Abstract
Clinical reactivations of herpes simplex virus or varicella zoster virus occur frequently among patients with malignancies and manifest particularly as herpes simplex stomatitis in patients with acute leukaemia treated with intensive chemotherapy and as herpes zoster in patients with lymphoma or multiple myeloma. In recent years, knowledge on reactivation rates and clinical manifestations has increased for conventional chemotherapeutics as well as for many new antineoplastic agents. This guideline summarizes current evidence on herpesvirus reactivation in patients with solid tumours and hematological malignancies not undergoing allogeneic or autologous hematopoietic stem cell transplantation or other cellular therapy including diagnostic, prophylactic, and therapeutic aspects. Particularly, strategies of risk adapted pharmacological prophylaxis and vaccination are outlined for different patient groups. This guideline updates the guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO) from 2015 “Antiviral prophylaxis in patients with solid tumours and haematological malignancies” focusing on herpes simplex virus and varicella zoster virus.
More than a feeling?—Overruling the preoperatively templated offset option leads to a minor offset increase in short stem total hip arthroplasty
Authors: Luger Matthias , Stadler Christian , Hochgatterer Rainer , Allerstorfer Jakob , Gotterbarm Tobias , Klasan Antonio 
Published: January 2022

Abstract
Purpose
Short stems are increasingly used in total hip arthroplasty (THA) because of advantages in bone and soft tissue preservation and reconstruction of hip geometry. Digital templating is essential in determining the correct offset option and stem size in THA. However, the preoperative template sizes might be intraoperatively overruled.

Patients and methods
We evaluated the effect of intraoperative overruling of the preoperatively templated offset option of a short curved stem on hip offset, leg length, implant positioning, and femoral canal fill index. The overruling was performed in case of intraoperative instability, telescoping, or both. A series of 1052 consecutive THAs with a cementless short curved stem and press-fit cup was retrospectively screened. One hundred patients with unilateral THA and a contralateral native and morphologically healthy hip as a reference met the inclusion criteria. Measurements were carried out on preoperative and 3 months anterior–posterior postoperative radiographs. Patients were divided according to the overruling by offset option or stem size.

Results
Hip offset was increased in all groups, but only with significant increase if an offset option + 1 was used intraoperatively (p = 0.025). LLD was restored without significance in all groups (p = 0.323; p = 0.157).

Conclusion
Intraoperative overruling of the preoperative digital template in cementless short stem total hip arthroplasty results in an increase of hip offset compared to a contralateral healthy hip. However, the increase is marginal and clearly under 5 mm compared to the contralateral healthy hip.
Clinical Outcomes of Patients with Combined Idiopathic Pulmonary Fibrosis and Emphysema in the IPF-PRO Registry
Authors: Kim Hyun J. , Snyder Laurie D. , Neely Megan L. , Hellkamp Anne S. , Hotchkin David L. , Morrison Lake D. , Bender Shaun , Leonard Thomas B. , Culver Daniel A. ,   the IPF-PRO™ Registry investigators
Published: January 2022

Abstract
Purpose
To assess the impact of concomitant emphysema on outcomes in patients with idiopathic pulmonary fibrosis (IPF).

Methods
The IPF-PRO Registry is a US registry of patients with IPF. The presence of combined pulmonary fibrosis and emphysema (CPFE) at enrollment was determined by investigators’ review of an HRCT scan. Associations between emphysema and clinical outcomes were analyzed using Cox proportional hazards models.

Results
Of 934 patients, 119 (12.7%) had CPFE. Compared with patients with IPF alone, patients with CPFE were older (median 72 vs 70 years); higher proportions were current/former smokers (88.2% vs 63.7%), used oxygen with activity (49.6% vs 31.9%) or at rest (30.8% vs 18.4%), had congestive heart failure (13.6% vs 4.8%) and had prior respiratory hospitalization (25.0% vs 16.7%); they had higher FVC (median 71.8 vs 69.4% predicted) and lower DLco (median 35.3 vs 43.6% predicted). In patients with CPFE and IPF alone, respectively, at 1 year, rates of death or lung transplant were 17.5% (95% CI: 11.7, 25.8) and 11.2% (9.2, 13.6) and rates of hospitalization were 21.6% (14.6, 29.6) and 20.6% (17.9, 23.5). There were no significant associations between emphysema and any outcome after adjustment for baseline variables. No baseline variable predicted outcomes better in IPF alone than in CPFE.

Conclusion
Approximately 13% of patients in the IPF-PRO Registry had CPFE. Physiologic characteristics and comorbidities of patients with CPFE differed from those of patients with IPF alone, but the presence of emphysema did not drive outcomes after adjustment for baseline covariates.

Trial registration
ClinicalTrials.gov, NCT01915511; registered August 5, 2013.
Innovative therapeutic concepts of progressive multifocal leukoencephalopathy
Authors: Möhn Nora , Grote-Levi Lea , Hopfner Franziska , Eiz-Vesper Britta , Maecker-Kolhoff Britta , Warnke Clemens , Sühs Kurt-Wolfram , Wattjes Mike P. , Höglinger Günter U. , Skripuletz Thomas 
Published: January 2022

AbstractProgressive multifocal leukoencephalopathy (PML) is an opportunistic viral disease of the brain—caused by human polyomavirus 2. It affects patients whose immune system is compromised by a corresponding underlying disease or by drugs. Patients with an underlying lymphoproliferative disease have the worst prognosis with a mortality rate of up to 90%. Several therapeutic strategies have been proposed but failed to show any benefit so far. Therefore, the primary therapeutic strategy aims to reconstitute the impaired immune system to generate an effective endogenous antiviral response. Recently, anti-PD-1 antibodies and application of allogeneic virus-specific T cells demonstrated promising effects on the outcome in individual PML patients. This article aims to provide a detailed overview of the literature with a focus on these two treatment approaches.