bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circular Economy trifft urban-regionale Resilienz – Synergien für eine nachhaltig-anpassungsfähige Stadtentwicklung
Authors: Fromhold-Eisebith Martina 
Published: December 2022

ZusammenfassungUm der Circular Economy bessere Möglichkeiten zur Integration in stadtregionale Strategien zu verschaffen, bietet sich die Verknüpfung mit weiter gefassten Zielen der Resilienz an. Die Konzepte der Urbanen und Regionalen Resilienz werden auch in Deutschland zunehmend als Ansatz für Zukunftsfähigkeit diskutiert. Sie sollen die Robustheit, Anpassungs- und Erholungsfähigkeit von Städten bzw. Regionen im Angesicht vielfältiger Krisen stärken, verknüpft mit Zielen der nachhaltigen Entwicklung. Der Beitrag zeigt einerseits auf, in welcher Hinsicht die kombinierte Sicht auf urban-regionale Resilienz einen geeigneten Rahmen für die effektive Einbettung systemischer Ansätze der Circular Economy ins stadträumliche Gefüge schafft. Andererseits wird erläutert, wie im Gegenzug auch die resiliente Abfederung umwelt- und wirtschaftsbezogener Risiken besser gelingen kann, wenn kreislaufwirtschaftliche Elemente integriert werden. Nach konzeptionellen Überlegungen zu synergetischen Wechselwirkungen dieser Prozessfelder dient das Beispiel der Stadt Aachen zur Illustration der zweckmäßigen Kombination von „Circular City“ und resilienzbezogenen Zielen. Dies macht deutlich, wie bedeutsam ein Fokus auf Innovationen für solche Strategieansätze ist. Am Ende werden Empfehlungen zur Gestaltung einer resilient-zirkulären Stadtökonomie formuliert.
Longitudinal changes in vitamin D concentrations and the association with type 2 diabetes mellitus: the Tromsø Study
Authors: Allaoui Giovanni , Rylander Charlotta , Fuskevåg Ole-Martin , Averina Maria , Wilsgaard Tom , Brustad Magritt , Jorde Rolf , Berg Vivian 
Published: December 2022

Abstract
Aim
We aimed to investigate the relationship between pre- and post-diagnostic 25-hydroxyvitamin D (25(OH)D) concentrations and type 2 diabetes (T2DM) over a period of 30 years in individuals who developed T2DM compared to healthy controls.

Methods
This case–control study included 254 participants with blood samples collected at five different time-points (T1–T5) between 1986 and 2016. Of the 254 participants, 116 were diagnosed with T2DM between T3 and T4, and were considered cases; the remaining 138 were controls. Linear mixed regression models were used to examine pre- and post-diagnostic changes in 25(OH)D concentrations, and logistic regression was used to examine associations between these concentrations and T2DM at each time-point.

Results
25(OH)D concentrations at different time-points and the longitudinal change in concentrations differed between cases and controls, and by sex. For women, each 5-nmol/l increase in 25(OH)D concentrations was inversely associated with T2DM at T3 (odds-ratio, OR, 0.79), whereas for men, this same increase was positively associated with T2DM at T1 (OR 1.12). Cases experienced a significant decrease in pre-diagnostic 25(OH)D concentrations (p value < 0.01 for women, p value = 0.02 for men) and a significant increase in post-diagnostic 25(OH)D concentrations (p value < 0.01 for women, p value = 0.01 for men). As such, each 1-unit increase in month-specific z-score change between T1 and T3 was significantly inversely associated with T2DM (OR 0.51 for women, OR 0.52 for men), and each such increase between T3 and T5 was significantly positively associated with T2DM in women (OR 2.48).

Conclusions
25(OH)D concentrations seem to be affected by disease progression and type 2 diabetes diagnosis.
Rapid detection of nanoplastics and small microplastics by Nile-Red staining and flow cytometry
Authors: Bianco Angelica , Carena Luca , Peitsaro Nina , Sordello Fabrizio , Vione Davide , Passananti Monica 
Published: December 2022

AbstractMicroplastics are of rising health concerns because they have been detected even in remote and pristine environments, from the Artic snow to the Marianne Trench. The occurrence and impact of nanoplastics in ecosystems is almost unknown, in particular due to analytical limitations such as very small sizes that fall below detection limits of current techniques. Here we take advantage of a common interference in analytical flow cytometry to develop a method for the quantification of the number of plastic particles in the 0.6–15 µm size range. Plastic particles are stained with the lipophilic dye Nile-Red then detected by flow cytometry, a method regularly used in biology for rapid quantification of fluorescent cells. We found that sample analysis lasts 90 s, which is hundreds of times faster than the analysis of filter portions by micro-Raman and other spectroscopic techniques. Our method is highly efficient in detecting polyethylene, with staining efficiency higher than 70% and signal linearity with concentration. Staining efficiency up to 96% was observed for polyvinylchloride and for polystyrene.
Assessment of fungal aerosols in a public library with natural ventilation
Authors: Camargo Caicedo Yiniva , Borja Pérez Hilary , Muñoz Fuentes Maryann , Vergara-Vásquez Eliana , Vélez-Pereira Andrés M. 
Published: December 2022

AbstractFungal aerosols deteriorate library collections and can impact human health, mainly via respiratory diseases. Their spread is influenced by factors such as temperature and relative humidity. This study aims to assess the concentration of fungal aerosols in the interior environment of the Popular Library of Gaira in the District of Santa Marta, Colombia, using a two-stage cascade impactor utilizing Sabouraud dextrose agar on Petri dishes for the collection of samples. The sampler was positioned at 1.5 m above ground level, operated with a flow rate of 28.3 l/min for 4 min and thermo-hygrometric conditions were also recorded. Concentrations in the air of up to 1197.0 CFU/m3 were reported, with a mean value close to 150 CFU/m3. Higher values during the morning samples were noted. Seven genera of fungi were found, Aspergillus and Curvularia were the most abundant. The temperature was between 30.80 and 33.51 °C, and the relative humidity was between 62.61 and 64.80%. Statistical analysis showed a significant correlation between the fungal aerosol concentration and relative humidity, where an increase of 10% in moisture could double the fungal aerosol concentration. We concluded that potentially favorable conditions exist indoors for the growth and survival of the following fungi: Aspergillus, Penicillium, Cladosporium, and Curvularia, and to a lesser extent for Chrysonilia, Cunninghamella, and Paecylomices. Relative humidity was seen to be the factor that affects the concentration of aerosols fungal in the library most significantly.
Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy
Authors: Nowak-Sliwinska Patrycja , van Beijnum Judy R. , Griffioen Christian J. , Huinen Zowi R. , Sopesens Nadine Grima , Schulz Ralph , Jenkins Samir V. , Dings Ruud P. M. , Groenendijk Floris H. , Huijbers Elisabeth J. M. , Thijssen Victor L. J. L. , Jonasch Eric , Vyth-Dreese Florry A. , Jordanova Ekaterina S. , Bex Axel , Bernards René , de Gruijl Tanja D. , Griffioen Arjan W. 
Published: December 2022

Abstract
Purpose
Ongoing angiogenesis renders the tumor endothelium unresponsive to inflammatory cytokines and interferes with adhesion of leukocytes, resulting in escape from immunity. This process is referred to as tumor endothelial cell anergy. We aimed to investigate whether anti-angiogenic agents can overcome endothelial cell anergy and provide pro-inflammatory conditions.

Experimental design
Tissues of renal cell carcinoma (RCC) patients treated with VEGF pathway-targeted drugs and control tissues were subject to RNAseq and immunohistochemical profiling of the leukocyte infiltrate. Analysis of adhesion molecule regulation in cultured endothelial cells, in a preclinical model and in human tissues was performed and correlated to leukocyte infiltration.

Results
It is shown that treatment of RCC patients with the drugs sunitinib or bevacizumab overcomes tumor endothelial cell anergy. This treatment resulted in an augmented inflammatory state of the tumor, characterized by enhanced infiltration of all major leukocyte subsets, including T cells, regulatory T cells, macrophages of both M1- and M2-like phenotypes and activated dendritic cells. In vitro, exposure of angiogenic endothelial cells to anti-angiogenic drugs normalized ICAM-1 expression. In addition, a panel of tyrosine kinase inhibitors was shown to increase transendothelial migration of both non-adherent and monocytic leukocytes. In primary tumors of RCC patients, ICAM-1 expression was found to be significantly increased in both the sunitinib and bevacizumab-treated groups. Genomic analysis confirmed the correlation between increased immune cell infiltration and ICAM-1 expression upon VEGF-targeted treatment.

Conclusion
The results support the emerging concept that anti-angiogenic therapy can boost immunity and show how immunotherapy approaches can benefit from combination with anti-angiogenic compounds.
Characterizing the Impact of the COVID-19 Pandemic on HIV PrEP care: A Review and Synthesis of the Literature
Authors: Hong Chenglin 
Published: December 2022

AbstractThe global COVID-19 pandemic and associated lockdown measures have caused disruptions to sexual health services and created additional barriers to the continuity of HIV pre-exposure prophylaxis (PrEP) among key populations. This review provides an examination of the influences of the pandemic on engagement in the PrEP care continuum. Using the PRISMA guideline, 46 studies were included in this review and the synthesis. Most of the studies were conducted in high-income settings through quantitative analysis. A majority of studies examining the changes in PrEP use suggested a decline or discontinuation in PrEP uptake during the pandemic. The most common reasons for stopping using PrEP were perceived barriers to PrEP-related care, having reduced sexual behaviors and fewer sexual partners, and reduced perceived risk of HIV infection. Limited studies documenting an increase in PrEP uptake were all in specific PrEP optimizing programs. During the pandemic, there is also an emerging trend of switching to on-demand PrEP from daily oral PrEP. Future studies should understand the mechanism of strategies that facilitated the improvements during the pandemic. PrEP implementation programs should consider alternative PrEP modalities and provide consistent and comprehensive knowledge about correct information.
Pamiparib in patients with locally advanced or metastatic HER2-negative breast cancer with germline BRCA mutations: a phase II study
Authors: Xu Binghe , Sun Tao , Shi Yanxia , Cui Jiuwei , Yin Yongmei , Ouyang Quchang , Liu Qiang , Zhang Qingyuan , Chen Yiding , Wang Shouman , Wang Xiaojia , Tong Zhongsheng , Zhong Yahua , Wang Jiayu , Yan Min , Yan Xi , Wang Chuan , Feng Jifeng , Wang Xiuli , Hu Gang , Cheng Ying , Ge Ruimin , Zhu Zhaoyin , Zhang Wa , Shao Zhimin 
Published: December 2022

Abstract
Purpose
To evaluate the efficacy and safety of pamiparib in patients with locally advanced or metastatic human epidermal growth factor receptor 2-negative (HER2−) breast cancer, with deleterious or suspected deleterious germline BRCA1/2 mutations (gBRCA1/2 m).

Methods
In this open-label, phase II, multicenter study in China (NCT03575065), patients with triple-negative breast cancer (TNBC cohort) or hormone receptor-positive (HR+)/HER2− breast cancer (HR+/HER2− cohort) and ≤ 2 prior lines of chemotherapy received pamiparib 60 mg orally twice daily in 28-day, continuous cycles. The primary endpoint was objective response rate (ORR; RECIST v1.1) by independent review committee.

Results
In total, 88 patients were enrolled (TNBC cohort: 62; HR+/HER2− cohort: 26). Median age was 45.5 (range: 27–67) years, and 60 patients (68.2%) had received 1 or 2 prior lines of chemotherapy; 42 patients (47.7%) had previously received platinum chemotherapy. In the TNBC cohort, ORR was 38.2% (95% confidence interval [CI] 25.4–52.3) and median duration of response (DoR) was 7.0 months (95% CI 3.9–not estimable). In the HR+/HER2− cohort, ORR was 61.9% (95% CI 38.4–81.9) and median DoR was 7.5 months (95% CI 5.6–14.8). The most common treatment-emergent adverse events (TEAEs), treatment-related TEAEs, and ≥ Grade 3 TEAEs were hematologic (including anemia, decreased neutrophil count, and decreased white blood cell count). Overall, 64.8% of patients had TEAEs leading to dose reduction and 2.3% had TEAEs leading to treatment discontinuation.

Conclusion
Pamiparib showed encouraging efficacy and an acceptable safety profile in patients with locally advanced and metastatic HER2− breast cancer with gBRCA1/2 m.

Trial registration
ClinicalTrials.gov, NCT03575065; July 2, 2018.
Oil structuring properties of electrospun Kraft lignin/cellulose acetate nanofibers for lubricating applications: influence of lignin source and lignin/cellulose acetate ratio
Authors: Rubio-Valle J. F. , Valencia C. , Sánchez M. , Martín-Alfonso J. E. , Franco J. M. 
Published: December 2022

AbstractIn the present work, electrospun Kraft lignin/cellulose acetate nanostructures were produced, assessed and proposed as structuring or thickening agents of castor oil for lubricating applications. Solutions of Kraft lignins (KL) derived from different sources (eucalyptus, poplar and olive tree pruning) and cellulose acetate (CA) were prepared and used as feed for electrospinning. The rheological properties (shear and extensional viscosity), electrical conductivity and surface tension of KL/CA solutions influence the morphology of the electrospun nanofibers, which in turn is affected by the chemical structure and composition of the Kraft lignins. Electrospun KL/CA nanostructures consisting of filament-interconnected nanoparticles, beaded nanofibers or uniform nanofiber mats were able to form gel-like homogeneous fine dispersions by simply mechanically dispersing them into castor oil. The swelling of KL/CA nanofibers in the percolation network was demonstrated. The rheological, tribological and microstructural properties of these oleogels are essentially governed by the morphological characteristics of the electrospun nanostructures, i.e. fiber diameter, number of beads and porosity. Rheological properties of the resulting oleogels may be tailored by modifying the lignin source and KL:CA weight ratio. According to their rheological and tribological properties, KL/CA electrospun nanostructures-based oleogels can be proposed as a sustainable alternative to conventional lubricating greases.
Forecast evaluation for data scientists: common pitfalls and best practices
Authors: Hewamalage Hansika , Ackermann Klaus , Bergmeir Christoph 
Published: December 2022

AbstractRecent trends in the Machine Learning (ML) and in particular Deep Learning (DL) domains have demonstrated that with the availability of massive amounts of time series, ML and DL techniques are competitive in time series forecasting. Nevertheless, the different forms of non-stationarities associated with time series challenge the capabilities of data-driven ML models. Furthermore, due to the domain of forecasting being fostered mainly by statisticians and econometricians over the years, the concepts related to forecast evaluation are not the mainstream knowledge among ML researchers. We demonstrate in our work that as a consequence, ML researchers oftentimes adopt flawed evaluation practices which results in spurious conclusions suggesting methods that are not competitive in reality to be seemingly competitive. Therefore, in this work we provide a tutorial-like compilation of the details associated with forecast evaluation. This way, we intend to impart the information associated with forecast evaluation to fit the context of ML, as means of bridging the knowledge gap between traditional methods of forecasting and adopting current state-of-the-art ML techniques.We elaborate the details of the different problematic characteristics of time series such as non-normality and non-stationarities and how they are associated with common pitfalls in forecast evaluation. Best practices in forecast evaluation are outlined with respect to the different steps such as data partitioning, error calculation, statistical testing, and others. Further guidelines are also provided along selecting valid and suitable error measures depending on the specific characteristics of the dataset at hand.
Parametric Amplification via Superconducting Contacts in a Ka Band Niobium Pillbox Cavity
Authors: Gilles V. , Banys D. , McCulloch M. A. , Piccirillo L. , Sweetnam T. 
Published: December 2022

AbstractSuperconducting parametric amplifiers are commonly fabricated using planar transmission lines with a nonlinear inductance provided by either Josephson junctions or the intrinsic kinetic inductance of the thin film. However, Banys et al. (J Low Temp Phys, 2020) reported nonlinear behaviour in a niobium pillbox cavity, hypothesising that below $$T_c$$

T
c

, the pair iris-bulk resonator would act as a superconducting contact surface exploiting a Josephson-like nonlinearity. This work investigates this effect further by applying Keysight Technologies’ Advanced Design System (ADS) to simulate the cavity using an equivalent circuit model that includes a user defined Josephson inductance component. The simulations show that for a resonance centred at $$\nu _0=30.649$$

ν
0

=
30.649

GHz, when two tones (pump and signal) are injected into the cavity, mixing and parametric gain occur. The maximum achievable gain is explored when the resonator is taken to its bifurcation energy. These results are compared to cryogenic measurements where the pump and the signal are provided by a Vector Network Analyzer.
Development of polymer electrolyte membrane based on poly(Vinyl Chloride)/graphene oxide modified with zirconium phosphate for fuel cell applications
Authors: Elerian Ahmed F. , Abu-Saied M. A. , Abd-Elnaim G. H. , Elnaggar Elsayed M. 
Published: December 2022

AbstractThe function of a membrane in the fuel cell is critical to its success. The major component of a direct methanol fuel cell (DMFC) is the proton exchange membrane (PEM) which must have proton conductivity, thermal stability, mechanical qualities, and low methanol permeability. In this study case, the film-forming and structural properties of Polyvinyl chloride (PVC) impelled us to employ them for developing polyelectrolyte membranes (PEMs). To functionalize the resultant PEMs, Graphene oxide (GO) and zirconium phosphate (ZrP) were incorporated into polyvinyl chloride in different proportions. The structural and physical properties of PVC/GO-ZrP membranes were investigated by using a variety of techniques instance, Fourier transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), Transmission electron microscope (TEM), Thermogravimetric analyzer (TGA), universal testing machine, and water contact angle meter. Furthermore, water uptake, Methanol uptake, and ion exchange capacity (IEC) were measured. The results demonstrated that the membranes developed have enough characteristics to be valid in DMFCs.
The phenomenology of maintenance goals: lower threat and greater satisfaction with the current state
Authors: Ecker Yael , Gilead Michael , Imhoff Roland 
Published: December 2022

AbstractThis research tested the mental experience of maintenance goals as distinct from goals to approach better outcomes (approach goals) and goals to avoid worse outcomes (avoidance goals). In Studies 1 and 2, participants reported personal goals and categorized them as one of the three goal types. We theorized that maintenance centers on existing positive outcomes, while avoidance centers on future (expected) negative outcomes. We therefore predicted a lesser experience of threat and a greater experience of satisfaction in maintenance compared to avoidance. Additionally, we predicted greater satisfaction in maintenance compared to approach goals, wherein motivation comes from the value of future (desired) positive outcomes rather than current ones. Confirming our predictions, participants rated personal maintenance goals as lower on threat (Study 1) and higher on satisfaction (Studies 1 and 2) compared to avoidance goals. Additionally, revealing the centrality of maintenance, maintenance goals played a major role in reported central life goals (Study 1) and the largest role in goals pursued in the previous week (Study 2). Finally, in Study 3, participants judged another person engaged in maintenance as more satisfied and less threatened than a person engaged in avoidance or approach. Taken together, this work informs about the phenomenological nature of maintenance and advances a theory-driven ternary taxonomy of basic goal types.
Impact of using authentic online learning environments on students’ perceived employability
Authors: Martínez-Argüelles María-Jesús , Plana-Erta Dolors , Fitó-Bertran Àngels 
Published: December 2022

AbstractThe digitalization and globalization of society and the corresponding impact on the rules of the labor market is shifting the education sector toward new pedagogical approaches that integrate wholly online methodologies. Sustainable Development Goal 4 advocates for inclusive and equitable quality education that promotes lifelong learning opportunities, and, as we have seen during the COVID-19 lockdown, online learning can play a key role. In a context where lifelong learning becomes crucial to maintaining graduates’ employability, the innovative teaching methodologies that promote employable competencies in online environments are especially desirable. With the purpose of improving the employability of students, this article analyses the impact of introducing the Authentic Learning Scenarios (ALS) paradigm in an online environment. We develop a quasi-experimental design. Based on the nine ALS criteria and their application to e-learning, we redesign a course in a business degree program. Data from 135 students were collected, with special focus on achieving general competences. We compare the perception of the competency profile attained between a group of students who took the course before incorporating the ALS paradigm and another group that took it once it had been redesigned. Results show that redesigning the course enables students to perceive the learning process as more authentic, as well as acquiring a more advanced competence profile. Besides this, it has been shown that technology can contribute to building cognitive authenticity in virtual classrooms, without the need for face-to-face internships, which are often not a feasible option for students of online programs.
The Impact of Linguistic Form of Labels on Desire for Social Distance in Mental Health
Authors: Mallinson Matt Geoffrey , Giannakopoulou Anastasia , Clements Andrew James 
Published: December 2022

AbstractThe American Psychological Association, among other influential bodies, make recommendations on language for describing people with mental health conditions. The present studies test the impact of the recommended language on stigma. In Study 1, participants (n = 294) were asked to complete measures of desire for social distance from individuals given a diagnostic label in either person-first possessive, identity-first noun, or identity-first adjective forms. Familiarity with the diagnoses was considered as a potential influence on the outcome. The 3*2 (linguistic form * experience) factorial design was repeated for three diagnoses - schizophrenia, anorexia and alcoholism. In Study 2, the research was replicated with a sample recruited from the UK population via social media (n = 230). Factorial ANOVA was used for analysis. In contrast with previous literature, the studies found neither an effect of linguistic form (hypothesis 1) nor an interaction effect with familiarity (hypothesis 2). Research on this topic is in an early stage and, above all, it remains important to use language, which shows respect when talking to or about others.