bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-molecule tracking reveals two low-mobility states for chromatin and transcriptional regulators within the nucleus
Authors: Wagh Kaustubh , Stavreva Diana A , Jensen Rikke AM , Paakinaho Ville , Fettweis Gregory , Schiltz R Louis , Wüstner Daniel , Mandrup Susanne , Presman Diego M , Upadhyaya Arpita , Hager Gordon L 
Published: July 2022

ABSTRACTHow transcription factors (TFs) navigate the complex nuclear environment to assemble the transcriptional machinery at specific genomic loci remains elusive. Using single-molecule tracking, coupled with machine learning, we examined the mobility of multiple transcriptional regulators. We show that H2B and ten different transcriptional regulators display two distinct low-mobility states. Our results indicate that both states represent dynamic interactions with chromatin. Ligand activation results in a dramatic increase in the proportion of steroid receptors in the lowest mobility state. Mutational analysis revealed that only chromatin interactions in the lowest mobility state require an intact DNA-binding domain as well as oligomerization domains. Importantly, these states are not spatially separated as previously believed but in fact, individual H2B and TF molecules can dynamically switch between them. Together, our results identify two unique and distinct low-mobility states of transcriptional regulators that appear to represent common pathways for transcription activation in mammalian cells.
Goal-directed action is transiently impaired in an hAPP-J20 mouse model of Alzheimer’s disease, and in aging male mice regardless of genotype
Authors: Dhungana Amolika , Becchi Serena , Leake Jessica , Morris Gary , Avgan Nesli , Balleine Bernard W. , Vissel Bryce , Bradfield Laura A. 
Published: July 2022

AbstractCognitive-behavioural testing in preclinical models of Alzheimer’s disease has typically been limited to visuo-spatial memory tests and has failed to capture the broad scope of deficits patients also display in goal-directed action control. The current study addresses this gap by providing the first comprehensive investigation of how goal-directed actions are affected in a transgenic mouse model of Alzheimer’s disease. Specifically, we tested outcome devaluation performance – a popular test of goal-directed action – in male and female human amyloid precursor protein (hAPP)-J20 mice. Mice were first trained to press a left and right lever for unique pellet and sucrose outcomes respectively (counterbalanced) over four days. On test, mice were fed one of the two outcomes to reduce its value via sensory specific satiety and subsequently given a choice between levers. Goal-directed action was intact for 36-week-old wildtype mice of both sexes, because they responded more on the lever associated with the still-valued outcome than that associated with the devalued outcome (i.e. Valued > Devalued). Goal-directed action was impaired (Valued = Devalued) for J20 mice of both sexes, and for 52-week-old male mice regardless of genotype. Following an additional 4 days of lever press training (i.e., 8 days lever pressing in total), outcome devaluation was intact for all mice regardless of age or genotype. Immunohistochemical analysis revealed that increased microglial expression in the dorsal CA1 region of the hippocampus was associated with poorer outcome devaluation performance on initial tests, but not with tests performed after 8 days of lever pressing. Together, these data demonstrate that goal-directed action is transiently impaired in J20 mice of both sexes and in aging male mice regardless of genotype, and that this impairment is related to neuroinflammation in the dorsal CA1 region of the hippocampus.
Constraints to formal small business performance in the service sector in Cameroon
Authors: Kabange Martin Mulunda , Simatele Munacinga 
Published: July 2022

PurposeThis study aims to investigate whether social capital mediates the impact of financial capital on business performance in Cameroon.Design/methodology/approachThe study uses quantitative data collected from 370 small businesses in Yaoundé and Douala in Cameroon. All businesses in the sample are formally registered and are in the services sector. A structural equation modelling (SEM) approach is used for the analysis.FindingsStructural and relational capital constraints are significant mediators of formal and informal finance. The magnitude effects of relational capital are the largest, underlining information's importance in resolving small and medium enterprises’ (SMEs') financial constraints. In addition, the effect of informal finance constraints on business performance is larger in magnitude, confirming the substantial impact of informal finance on SME operations.Research limitations/implicationsThe paper confirms that relational and structural social capital are vital in business. However, the study did not investigate the disaggregated effects of these dimensions of social capital. Furthermore, how SMEs transition between formal and informal finance could provide further understanding of the role of social capital. A disaggregated and panel data set would help to provide additional insights.Practical implicationsSocial capital emerges as a pivotal factor in enhancing SME access to finance. The results, therefore, confirm the relevance of a holistic approach to easing financial capital constraints for SMEs and enabling small businesses to connect more to various stakeholders to amplify business performance. In addition, the findings identified some intervention points for the governments in Cameroon as it seeks to use SMEs as its pivot for development and to catapult itself to emerging economy status in its Cameroon 2035 vision.Originality/valueThe value of the study lies in assessing the mediating effect of cognitive, relational and structural social capital constraints on business performance and comparing the effect of formal and informal financial constraints on business performance.
OFDI activity and urban-regional development cycles: a co-evolutionary perspective
Authors: Bathelt Harald , Buchholz Maximilian , Cantwell John A. 
Published: July 2022

Purpose
While conventional views of foreign investment activity primarily relate to efficiency-seeking investments, the authors argue that most other outward foreign direct investments (OFDIs) likely have positive effects on income development in the home region. Data on the US urban system not only illustrates this but also shows that this impact is not equal in all city-regions. The purpose of this paper is to develop an explanation as to why high- and low-income cities are associated with self-reinforcing cycles of OFDI activity that have different home-region impacts.

Design/methodology/approach
Conventional views assume that inward foreign direct investments (IFDIs) have a positive impact on target regions, while OFDIs are often treated as the flip side of this story, being seen as having negative effects by shifting jobs and income abroad. This paper counters this logic by developing a conceptual argument that systematically distinguishes different types of OFDIs and relates them to economic development effects in the home (investing) region.

Findings
Using a co-evolutionary conceptualization, this paper suggests that many high-income cities are characterized by a virtuous cycle of development where high, successful OFDI activity generates both positive income effects as well as incentives to engage in further OFDIs in the future, thus leading to additional income increases. In contrast, it is suggested that low-income cities are characterized by what we refer to as vicious cycles of development with low OFDI activity, few development impulses and a lack of incentives and capabilities for future investments.

Originality/value
This paper develops a counter-perspective to conventional views of OFDI activity, arguing that these investments have a positive impact on regional income levels. The authors develop a spatially sensitive explanation which acknowledges that OFDIs do not trigger a linear process but are associated with diverging inter-urban development paths and may contribute to higher levels of intra-urban inequality. From these findings, the authors derive conclusions for future research and public policy.
Computational fluid dynamics (CFD) based propeller design improvement for high altitude long endurance (HALE) UAV
Authors: Maulana Fatwa Azam , Amalia Ema , Moelyadi Mochammad Agoes 
Published: July 2022

PurposeHigh Altitude Long Endurance Unmanned Aerial Vehicle (HALE UAV) driven by a hybrid power between battery and solar panel have attracted many researchers. The HALE UAV which develops at Bandung Institute of Technology has design requirements of a 63 kg MTOW with a cruise velocity of 22.1 m/s at an altitude of 60,000 ft propelled by two propellers. The main problems that arise with the propellers gained from the market are these propellers cannot operate properly at the cruise phase due to inadequate thrust and high drag value. This paper aims to design a propeller that solves those problems.Design/methodology/approachThe Larrabee method is used to design this propeller geometry with an output in the form of a chord and twist distribution. The CFD approach method is used to improve the design resulting from the Larrabee method.FindingsThis study shows that the inputted thrust value of the propeller designed using the Larrabee method is always higher than the thrust value resulting from the CFD simulation with a difference of around 20% so a design improvement process using CFD is required.Originality/valueThe analysis of propeller implementation in various mission profiles shows that this propeller can operate fully from climbing at sea level to cruising flight at an altitude of 60,000 ft. The same procedure can be applied in other HALE UAV cases to generate a propeller design with different objectives.
Effect of graphitization percentage on fade and recovery performance of copper-free non-asbestos organic brake pads
Authors: G. Saikrishnan , L.S. Jayakumari , R. Vijay 
Published: July 2022

Purpose
The purpose of this paper is to deal with the tribological study on the brake pads developed using various purity-based graphitized graphite.

Design/methodology/approach
This paper deals with developing copper-free brake pads by using graphite as a key lubricant produced using a graphitization process with purity percentages (85, 90 and 95%). The brake pads were developed using traditional manufacturing processes and evaluated for their physical, chemical, thermal and mechanical properties as per industrial standards. Fade and recovery characteristics were analyzed using a full-scale inertia brake dynamometer as per JASO-C-406. The scanning electron microscope was used to analyze the worn surfaces of the brake pads.

Findings
The testing findings reveal that the brake pads with 95% graphitized graphite showed better shear strength with good adhesion levels and lesser density, hardness, acetone extract value, loss on ignition and higher porosity. Effectiveness studies of brake pads with graphite (95% graphitized) showed better results at higher pressure speed conditions than others because of better plateau formation and adequate lubrication.

Originality/value
This paper discusses graphitized graphite of different purity influences brake pad's tribological performance by modifying tribo-films and reducing friction undulations.
Mental health and criminal justice: bridging two worlds
Authors: Madondo Chrispen , Van der Putten Marc 
Published: July 2022

Purpose
The purpose of this study was to describe programs that aim at programs to divert people with a mental condition from the criminal justice system to mental health services are being initiated, but reporting is limited and fragmented. This study described programs that aim at diverting persons with mental health conditions out of criminal justice systems to community mental health services, with the intention to inform research and practice.

Design/methodology/approach
A scoping review was used to map and synthesise diversion programs. Ten online data bases were searched. Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews was used to direct the selection of sources. Research and evaluation publications and grey literature published from 2010 to 2021 in English language were included.

Findings
Eight distinct diversion programs were identified across 24 countries or territories covering five phases of the criminal justice process. Diversion programs included crisis intervention teams, the electronic linkage system, mobile crisis units, the criminal justice liaison program, problem-solving courts, the abstinence-based program, the community equivalence program and the forensic assertive community treatment program. Although distinct programs have the potential to form a system of diversion across the continuum of the criminal justice process, only two territories moved in that direction. Diversion programs reported overwhelmingly originated from high-income countries.

Practical implications
Stigma that labels people with mental health conditions as violent and dangerous need to be addressed. It is important to place diversion systems on national policy agendas and advocate for evidence-based interventions.

Originality/value
The study provides a blueprint on diversion systems to set a research agenda and develop a road map, tailored towards local contexts.
From service to social innovation with a service-dominant logic approach
Authors: Barrios Andrés , Camacho Sonia , Estrada-Mejia Catalina 
Published: July 2022

Purpose
This paper aims to explore the intersection between service and social innovation, using a service-dominant logic (SDL) ecosystem approach to analyze how service innovations cocreate transformative value for individuals and communities.

Design/methodology/approach
A case study, with different data sources, is used to understand different innovations in a program that provides financial training to women in poverty in Colombia.

Findings
In the program’s service ecosystem, actors worked in tandem to develop dialogical service innovations. These service innovations transformed into social innovations, cocreating transformative value at different levels of the service ecosystem, including beneficiaries, families and communities.

Research limitations/implications
First, this study illustrates how, during service value cocreation experiences, a dialogical innovation path occurs with the simultaneous participation of different service entities. Second, it uses transformative value cocreation to integrate service and social innovations conceptually. Third, it reveals how service innovation cocreates transformative value at different levels of the service ecosystem. Fourth, it shows how technology in its material and immaterial forms, working as an operand and operant role, respectively, facilitates service innovations.

Practical implications
This study illustrates how a wider service focus including all actors involved, in addition to a holistic view of beneficiaries, can prompt service and social innovations.

Originality/value
Service and social innovations have been seen as parallel fields. This study uses SDL to integrate these types of innovation processes and outcomes by applying the concept of transformative value.
When do ethnic networks help with foreign direct investment location?
Authors: Alcaraz Jorge , Salamanca Elizabeth 
Published: July 2022

Purpose
The purpose of this paper is to identify how the cultural attributes of ethnic networks affect foreign direct investment (FDI) location.

Design/methodology/approach
The study tests on panel data the effect of ethnic networks in interaction with their member’s cultural attributes on FDI location.

Findings
Results show that ethnic networks whose members predominantly exhibit a human orientation do not affect FDI location. However, when performance orientation is the predominant cultural attribute of the members of an ethnic network, there is a positive and significant effect on FDI location.

Practical implications
Managers need to be aware that not all networks will be equally helpful in achieving particular goals. For instance, ethnic networks where the performance orientation is dominant among their members affect FDI location, unlike ethnic networks where human orientation is dominant. Therefore, decision-makers need to identify and align these two elements (networks and goals) to maximize outcomes.

Originality/value
This study contributes to the literature by suggesting that FDI location is affected by ethnic networks where performance orientation is dominant among the members, which is not the case when human orientation is dominant among the members of the ethnic networks.
Interview with RD Hinshelwood
Authors: Hinshelwood Robert Douglas , Winship Gary 
Published: July 2022

Purpose
A one-day conference organised by the University of Essex and the Consortium of Therapeutic Communities, 10 December, 2021 with the theme, “The Unconscious and Organisations”. Presentations and discussions throughout the conference had the aim of generating ideas and sharing knowledge about the unconscious and how this can inform practitioners working in therapeutic communities and other organisations meeting the challenge of emotional distress.

Design/methodology/approach
Interview with Professor Robert (Bob) Hinshelwood (RH), now 83 years old, who has been involved in therapeutic communities (TCs) since 1969, part of the initial founding of the Association of Therapeutic Communities in 1974, is presented. He qualified as a psychoanalyst in 1976. In 1980 he instigated the founding of the International Journal of Therapeutic Communities along with Nick Manning, David Kennard, Jeff Roberts and Barry Shenkar. In 1984 he founded the British Journal of Psychotherapy, and edited it for 10 years. He was Director of the Cassel Hospital 1993–1997. In 1999 he founded the journal Psychoanalysis and History. He was part of the Free Associations Group (founded by Bob Young and others) which ran the journal Free Associations, and with Mike Rustin and the University of East London, the “Psychoanalysis and Public Sphere” conferences in the 1990s. He has written a great deal about the dynamics of organisational cultures in complex settings. He is Fellow of the British Psychoanalytical Society, Fellow of the Royal College of Psychiatrists and Professor Emeritus of the University of Essex. The interviewer was conducted by Dr Gary Winship (GW) is an associate professor at the University of Nottingham where he leads the MA in Trauma Informed Practice, visiting professor Moscow Institute of Psychoanalysis, and also visiting professor at the Russian State Humanities University, editor of the International Journal of Therapeutic Communities.

Findings
Hinshelwood reflects on the question of the unconscious and the impact of destructive tendencies on organisational process. He shares his personal experience being a young evacuee during the Second World War and considers the impact of trauma, losing his religion and his subsequent career choices in medicine, psychiatry and psychoanalysis. He discusses his experience of supervision with Isabel Menzies Lyth and reflects on the different groups in the Institute of Psychoanalysis. He turns to the question tribalism in TCs and regrets that there had not been more bridge building and collaboration. He talks about his own prolific writing and publishing career which he describes as obsessional rather than passionate, and finally candidly reflects on the prospect of facing death.

Originality/value
The interview was transcribed.
European regional inequalities in citizens’ digital interaction with government
Authors: Rodríguez-Hevía Luisa Fernanda , Rodríguez-Fernández Laura , Ruiz-Gómez Luis Manuel 
Published: July 2022

Purpose
The purpose of this research is to study what factors influence European citizens in their interaction with government in the EU regions. It analyses the differences across European regions, taking account of each region’s degree of economic development and incorporating different spatially tailored approaches into the analysis.

Design/methodology/approach
A logistic regression analysis was used to establish whether the profiles of e-Government users differ according to the development tier they live in and other explanatory variables: socio-demographic, digital skills and type of internet connection.

Findings
This research identifies regional inequalities in EU citizens’ digital behaviour with public administration. This statistical study of European regions allows to better apprehend the profile of the EU’s e-citizens and offers conclusions to explain citizens’ behaviour, highlighting the influence of several variables.

Originality/value
Given the lack of pan-European e-government studies at a regional level, this article provides a comparative analysis for the European Union and gives insights into the behaviour of European e-citizens, highlighting the presence of digital inequalities in Europe depending on the region where citizens reside.
Knowledge sharing and knowledge hiding in light of the mistakes acceptance component of learning culture- knowledge culture and human capital implications
Authors: Kucharska Wioleta , Rebelo Teresa 
Published: July 2022

Purpose
This study aims to examine the micromechanisms of how knowledge culture fosters human capital development.

Design/methodology/approach
An empirical model was developed by using the structural equation modeling method based on a sample of 321 Polish knowledge workers employed in different industries.

Findings
This study provides direct empirical evidence that tacit knowledge sharing supports human capital, whereas tacit knowledge hiding does not, and this hiding is considered a waste of knowledge. If tacit knowledge does not circulate within an organization, it is a severe waste of an organization. The findings indicate that shame from making mistakes might impede the sharing of knowledge gained from making those mistakes, and in such cases, the knowledge remains hidden.

Practical implications
Leaders aiming to ensure human capital growth should implement an authentic learning culture composed of a learning climate and mistakes acceptance components that enable open discussion about mistakes on each organizational level.

Originality/value
The knowledge culture is found to be an essential element of building human capital but, at the same time, not sufficient without a learning culture, and its mistakes acceptance component. A permanent organizational learning mode that supports a continuous organizational shared mental model reframing is an antidote to tacit knowledge hiding.