bluuebunny/crossref_metadata_2025_split huggingface dataset:
Between War and Peace, Past and Future: Experiencing the Hiroshima Peace Memorial Park
Authors: Brescó de Luna Ignacio , Li Yuanhang , Wagoner Brady 
Published: October 2022

AbstractHiroshima Peace Memorial Park is widely known as a universal symbol of peace, but there have not been studies of how people actually experience and interpret it. This article presents a detailed case study of a visit to the memorial by using an innovative methodology based on the use of subjective cameras (subcams). Results show that despite the monolithic idea of peace that the memorial officially represents, it is experienced and interpreted in terms of a constant tension which exposes conflicts in post-war Japan memory politics. The dichotomies of war/peace, death/life, past/future, and old /new emerge as part of the participant’s encounter with different situations during his visit. This is particularly clear where he perceives border zones and points of intersection. The article concludes by interpreting these dichotomies through the notion of themata, as elementary dichotomies that underlie a social debate around a specific topic. Specifically, two themata are proposed: one revolving around the temporal problematisation of the past and the future in the memory politics of the A-Bomb, and the other revolving around the spatial dichotomy between the old and the new underlying Hiroshima’s urban renewal.
Cognitive Remittances and the Reintegration ‘Hump’: Changing Self-Perceptions and Positionality among Roma Returnees in Albania and Kosovo
Authors: Vathi Zana , King Russell , Gëdeshi Ilir 
Published: October 2022

Abstract
Using the innovative concept of cognitive remittances, this paper looks at the transformation of the self-perception and positionality of Roma returned asylum-seekers. The empirical evidence, in the form of interview narratives and focus group quotes, is drawn from two research projects based in Albania and Kosovo and the wider Western Balkan region. The findings show that the migration and asylum-seeking experience, in Germany and other EU countries, provide the Roma with a new lens through which they can view and appreciate their historical and contemporary belongingness in the Western Balkan countries. Having been exposed to different lifestyles and values, they face real challenges upon return, where they have to confront anew very low living standards, socio-economic marginalisation and unfavourable positioning in the social hierarchy. We label this the reintegration ‘hump’. A cognitive shift occurs and their self-perception changes, including a greater sensitivity to experiences of discrimination. Reintegration is both hampered and potentially enabled by their enhanced political literacy and agency.
ETEOCLES’ AESCHYLEAN DREAM IN STATIUS’THEBAIDTHROUGH THE READER'S EYES
Authors: Arampapaslis Konstantinos 
Published: October 2022

AbstractThis article explores the intertextual connection between Eteocles’ dream in Statius’ThebaidBook 2 and the brief reference to his ambiguous dream at Aesch.Sept.710−11. In Aeschylus’ play, Eteocles understands the true meaning of the dream belatedly, as he is about to enter into a duel with his brother Polynices. The article argues that the ambiguous character of the Aeschylean dream forms the basis of the dream in Statius, and that the poet develops the scene further through elements of epic dream sequences that align his narrative with the epic tradition. However, Statius emphasizes even more the ambiguity of Eteocles’ dream to highlight the tragic nature of his character. Following ancient dream theorists, the discussion shows next that the obscurity of the dream in theThebaidcan be understood as the product of the fusion of different dream classes, which are evoked in the description of the dream in Statius. The proposed interpretation suggests that, on the basis of their personal experience of dreams and their familiarity with popular dream theories, Statius’ readers would have been able to perceive the irony between Laius’ message and Jupiter's true intentions, all of which enhance Eteocles’ tragic character.
ALEXANDRIA AD AEGYPTVM: THE (DIS)CONNECTION BETWEEN ALEXANDRIA AND EGYPT
Authors: De Graaf Ruben 
Published: October 2022

AbstractThe ancient city of Alexandria was often referred to as Alexandria ad Aegyptum in Roman documentary, epigraphic and literary sources; this phrase was translated in Greek as ἡ Ἀλεξάνδρεια ἡ πρὸς Αἰγύπτῳ. The grammatical phrasing implies that Alexandria was seen as being ‘near’ or ‘next to’ Egypt, not ‘in’ Egypt. This observation has given rise to the scholarly view that Alexandria was not part of Egypt. In this article the function of the designation ad Aegyptum and of similar designations within literary, papyrological and epigraphic sources ranging from 300 b.c.e. to 640 c.e. will be closely examined. This article argues that the expression can be seen as reflecting both the distinction and the close connection between Alexandria and Egypt on the basis of geographical, political and socio-cultural factors.
Cortical gyrification differences between early- and late-onset obsessive–compulsive disorder: neurobiological evidence for neurodevelopmentally distinct subtypes
Authors: Park Inkyung , Ha Minji , Kim Taekwan , Lho Silvia Kyungjin , Moon Sun-Young , Kim Minah , Kwon Jun Soo 
Published: October 2022

AbstractBackgroundIdentifying more homogenous subtypes of patients with obsessive–compulsive disorder (OCD) using biological evidence is critical for understanding complexities of the disorder in this heterogeneous population. Age of onset serves as a useful subtyping scheme for distinguishing OCD into two subgroups that aligns with neurodevelopmental perspectives. The underlying neurobiological markers for these distinct neurodevelopmental differences can be identified by investigating gyrification changes to establish biological evidence-based homogeneous subtypes.MethodsWe compared whole-brain cortical gyrification in 84 patients with early-onset OCD, 84 patients with late-onset OCD, and 152 healthy controls (HCs) to identify potential markers for early neurodevelopmental deficits using the local gyrification index (lGI). Then, the relationships between lGI in clusters showing significant differences and performance in visuospatial memory and verbal fluency, which are considered trait-related neurocognitive impairments in OCD, were further examined in early-onset OCD patients.ResultsThe early-onset OCD patients exhibited significantly greater gyrification than those with late-onset OCD patients and HCs in frontoparietal and cingulate regions, including the bilateral precentral, postcentral, precuneus, paracentral, posterior cingulate, superior frontal, and caudal anterior cingulate gyri. Moreover, impaired neurocognitive functions in early-onset OCD patients were correlated with increased gyrification.ConclusionsOur findings provide a neurobiological marker to distinguish the OCD population into more neurodevelopmentally homogeneous subtypes, which may contribute to the understanding of the neurodevelopmental underpinnings of an etiology in early-onset OCD consistent with the accumulated phenotypic evidence of greater neurodevelopmental deficits in early-onset OCD than in late-onset OCD.
Phonological Working Memory and Sentence Production in School-Age Children with Typical Language, Dyslexia, and Comorbid Dyslexia and Developmental Language Disorder
Authors: METTLER Heidi M. , ALT Mary , GRAY Shelley , HOGAN Tiffany P. , GREEN Samuel , COWAN Nelson 
Published: October 2022

AbstractPurposeLittle is known about the relationship between sentence production and phonological working memory in school-age children. To fill this gap, we examined how strongly these constructs correlate. We also compared diagnostic groups’ working memory abilities to see if differences co-occurred with qualitative differences in their sentences.MethodWe conducted Bayesian analyses on data from seven- to nine-year-old children (n = 165 typical language, n = 81 dyslexia-only, n = 43 comorbid dyslexia and developmental language disorder). We correlated sentence production and working memory scores and conducted t tests between groups’ working memory scores and sentence length, lexical diversity, and complexity.ResultsCorrelations were positive but weak. The dyslexic and typical groups had dissimilar working memory and comparable sentence quality. The dyslexic and comorbid groups had comparable working memory but dissimilar sentence quality.ConclusionContrary to literature-based predictions, phonological working memory and sentence production are weakly related in school-age children.
Imagery re-scripting for PTSD: session content and its relation to symptom improvement
Authors: Brown Gary , Salter Caroline , Parker Eleanor , Murray Hannah , Looney Kathy , El Leithy Sharif , Medin Evelina , Novakova Barbora , Wheatley Jonathan 
Published: October 2022

AbstractImagery rescripting (ImRs) is a therapy technique that, unlike traditional re-living techniques, focuses less on exposure and verbal challenging of cognitions and instead encourages patients to directly transform the intrusive imagery to change the depicted course of events in a more desired direction. However, a comprehensive account of how and in what circumstances ImRs brings about therapeutic change is required if treatment is to be optimised, and this is yet to be developed. The present study reports on the development of a coding scheme of ImRs psychotherapy elements identified in the literature as potential ImRs mechanisms. The codes were assessed in relation to short-term outcomes of 27 individuals undergoing ImRs for post-traumatic stress disorder. The timing of the change in the image, degree of activation of the new image and associated cognitive, emotional and physiological processes, self-guided rescripting, rescript believability, narrative coherence and cognitive and emotional shift were identified as being related to symptom change and so are potentially important factors for the re-scripting process.
The Politics of Welfare Retrenchment: Evidence from Mass Medicaid Disenrollment in Two States
Authors: Kogan Vladimir 
Published: October 2022

AbstractIn 2005, Missouri and Tennessee tightened eligibility for their public health insurance programs, resulting in widespread coverage losses. Leveraging county-level variation in subsequent disenrollment, I show that voters in Tennessee punished the incumbent governor for the Medicaid cuts. In Missouri, by contrast, disenrollment had no impact on the subsequent gubernatorial election but did increase support for Democrats in 2006 state legislative elections, possibly due to the strategic entry and exit of candidates. In both states, the loss of Medicaid coverage was associated with lower support for Democratic presidential candidates, although these declines appear part of a longer-term trend that preceded the coverage loss. The results speak to the potential political costs of welfare spending cuts and the electoral consequences of reducing income-targeted social programs.
Error and Uncertainty Degrade Topographic Corrections of Remotely Sensed Data
Authors: Dozier Jeff , Bair Edward H. , Baskaran Latha , Brodrick Philip G. , Carmon Nimrod , Kokaly Raymond F. , Miller Charles E. , Miner Kimberley R. , Painter Thomas H. , Thompson David R. 
Published: October 2022

AbstractChemical and biological composition of surface materials and physical structure and arrangement of those materials determine the intrinsic reflectance of Earth's land surface. The apparent reflectance—as measured by a spaceborne or airborne sensor that has been corrected for atmospheric attenuation—depends also on topography, surface roughness, and the atmosphere. Especially in Earth's mountains, estimating properties of scientific interest from remotely sensed data requires compensation for topography. Doing so requires information from digital elevation models (DEMs). Available DEMs with global coverage are derived from spaceborne interferometric radar and stereo‐photogrammetry at ∼30 m spatial resolution. Locally or regionally, lidar altimetry, interferometric radar, or stereo‐photogrammetry produces DEMs with finer resolutions. Characterization of their quality typically expresses the root‐mean‐square (RMS) error of the elevation, but the accuracy of remotely sensed retrievals is sensitive to uncertainties in topographic properties that affect incoming and reflected radiation and that are inadequately represented by the RMS error of the elevation. The most essential variables are the cosine of the local solar illumination angle on a slope, the shadows cast by neighboring terrain, and the view factor, the fraction of the overlying hemisphere open to the sky. Comparison of global DEMs with locally available fine‐scale DEMs shows that calculations with the global products consistently underestimate the cosine of the solar angle and underrepresent shadows. Analyzing imagery of Earth's mountains from current and future spaceborne missions requires addressing the uncertainty introduced by errors in DEMs on algorithms that analyze remotely sensed data to produce information about Earth's surface.
Clonal relationship and alcohol consumption-associated mutational signature in synchronous hypopharyngeal tumours and oesophageal squamous cell carcinoma
Authors: Ko Josephine Mun-Yee , Guo Chen , Liu Conghui , Ning Lvwen , Dai Wei , Tao Lihua , Lo Anthony Wing-Ip , Wong Carissa Wing-Yan , Wong Ian Yu-Hong , Chan Fion Siu-Yin , Wong Claudia Lai-Yin , Chan Kwan Kit , Law Tsz Ting , Lee Nikki Pui-Yue , Liu Zhichao , Jiang Haoyao , Li Zhigang , Law Simon , Lung Maria Li 
Published: October 2022

Abstract
Background
The patients with dual oesophageal squamous cell carcinoma (ESCC) and hypopharyngeal cancer (HPC) have poor prognosis; their underlying genetic pathogenesis is unclear. We hypothesise that development of synchronous ESCC/HPC depends on multicentricity or independent origin, rather than multifocality due to local or lateral spreading.

Method
Multiple region whole-exome sequencing (M-WES) and clonality analysis were used to assess clonal relationship and spatial inter- or intra-tumour heterogeneity (ITH) in 62 tumour regions from eight dual ESCC/HPC and ten ESCC patients.

Results
All synchronous ESCC/HPC patients had COSMIC 16 mutation signatures, compared to only 40% ESCC in the current study (p = 0.013) and public data set (n = 165, p = 0.003). This alcohol consumption-related mutation signature 16, commonly involved in multiple alcohol-related cancers, was significantly associated with drinking and alcohol metabolism-related ADH1B rs1229984. The mutational landscape and copy number profiles were completely distinct between the two primary tumours; clonality analysis further suggested the two primary tumours shared no or only one clone accompanying independent subclone evolution. M-WES strategy demonstrated higher sensitivity and accuracy for detection of mutational prevalence and the late branch mutations among different regions in the ESCC tumours, compared to traditional sequencing analysis based on single biopsy strategy. Patients with high ITH assessed by cancer cell fraction analysis after M-WES were significantly associated with both relapse and survival.

Conclusions
Our hypothesis-generating M-WES ITH assessment data have implications for prognostication. Collectively, our findings support multicentric independent clonal evolution, the field cancerisation theory, and suggest novel insights implicating an aetiologic role of alcohol metabolism in dual ESCC/HPC carcinogenesis.
Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications
Authors: Iannielli Angelo , Luoni Mirko , Giannelli Serena Gea , Ferese Rosangela , Ordazzo Gabriele , Fossati Matteo , Raimondi Andrea , Opazo Felipe , Corti Olga , Prehn Jochen H. M. , Gambardella Stefano , Melki Ronald , Broccoli Vania 
Published: October 2022

AbstractTriplication of the SNCA gene, encoding the protein alpha-Synuclein (αSyn), is a rare cause of aggressive and early-onset parkinsonism. Herein, we generated iPSCs from two siblings with a recently described compact SNCA gene triplication and suffering from severe motor impairments, psychiatric symptoms, and cognitive deterioration. Using CRISPR/Cas9 gene editing, each SNCA copy was inactivated by targeted indel mutations generating a panel of isogenic iPSCs with a decremental number from 4 down to none of functional SNCA gene alleles. We differentiated these iPSC lines in midbrain dopaminergic (DA) neuronal cultures to characterize αSyn aggregation in native and seeded conditions and evaluate its associated cellular dysfunctions. Utilizing a new nanobody-based biosensor combined with super-resolved imaging, we were able to visualize and measure αSyn aggregates in early DA neurons in unstimulated conditions. Calcium dysregulation and mitochondrial alterations were the first pathological signs detectable in early differentiated DA neuronal cultures. Accelerated αSyn aggregation was induced by exposing neurons to structurally well-characterized synthetic αSyn fibrils. 4xSNCA DA neurons showed the highest vulnerability, which was associated with high levels of oxidized DA and amplified by TAX1BP1 gene disruption. Seeded DA neurons developed large αSyn deposits whose morphology and internal constituents resembled Lewy bodies commonly observed in Parkinson’s disease (PD) patient brain tissues. These findings provide strong evidence that this isogenic panel of iPSCs with SNCA multiplications offers a remarkable cellular platform to investigate mechanisms of PD and validate candidate inhibitors of native and seeded αSyn aggregation.
Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development
Authors: Nagata Kosei , Hojo Hironori , Chang Song Ho , Okada Hiroyuki , Yano Fumiko , Chijimatsu Ryota , Omata Yasunori , Mori Daisuke , Makii Yuma , Kawata Manabu , Kaneko Taizo , Iwanaga Yasuhide , Nakamoto Hideki , Maenohara Yuji , Tachibana Naohiro , Ishikura Hisatoshi , Higuchi Junya , Taniguchi Yuki , Ohba Shinsuke , Chung Ung-il , Tanaka Sakae , Saito Taku 
Published: October 2022

AbstractThe Runt-related transcription factor (Runx) family plays various roles in the homeostasis of cartilage. Here, we examined the role of Runx2 and Runx3 for osteoarthritis development in vivo and in vitro. Runx3-knockout mice exhibited accelerated osteoarthritis following surgical induction, accompanied by decreased expression of lubricin and aggrecan. Meanwhile, Runx2 conditional knockout mice showed biphasic phenotypes: heterozygous knockout inhibited osteoarthritis and decreased matrix metallopeptidase 13 (Mmp13) expression, while homozygous knockout of Runx2 accelerated osteoarthritis and reduced type II collagen (Col2a1) expression. Comprehensive transcriptional analyses revealed lubricin and aggrecan as transcriptional target genes of Runx3, and indicated that Runx2 sustained Col2a1 expression through an intron 6 enhancer when Sox9 was decreased. Intra-articular administration of Runx3 adenovirus ameliorated development of surgically induced osteoarthritis. Runx3 protects adult articular cartilage through extracellular matrix protein production under normal conditions, while Runx2 exerts both catabolic and anabolic effects under the inflammatory condition.
Systematic design of cell membrane coating to improve tumor targeting of nanoparticles
Authors: Liu Lizhi , Pan Dingyi , Chen Sheng , Martikainen Maria-Viola , Kårlund Anna , Ke Jing , Pulkkinen Herkko , Ruhanen Hanna , Roponen Marjut , Käkelä Reijo , Xu Wujun , Wang Jie , Lehto Vesa-Pekka 
Published: October 2022

AbstractCell membrane (CM) coating technology is increasingly being applied in nanomedicine, but the entire coating procedure including adsorption, rupture, and fusion is not completely understood. Previously, we showed that the majority of biomimetic nanoparticles (NPs) were only partially coated, but the mechanism underlying this partial coating remains unclear, which hinders the further improvement of the coating technique. Here, we show that partial coating is an intermediate state due to the adsorption of CM fragments or CM vesicles, the latter of which could eventually be ruptured under external force. Such partial coating is difficult to self-repair to achieve full coating due to the limited membrane fluidity. Building on our understanding of the detailed coating process, we develop a general approach for fixing the partial CM coating: external phospholipid is introduced as a helper to increase CM fluidity, promoting the final fusion of lipid patches. The NPs coated with this approach have a high ratio of full coating (~23%) and exhibit enhanced tumor targeting ability in comparison to the NPs coated traditionally (full coating ratio of ~6%). Our results provide a mechanistic basis for fixing partial CM coating towards enhancing tumor accumulation.
Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor
Authors: Bayly-Jones Charles , Lupton Christopher J. , Fritz Claudia , Venugopal Hariprasad , Ramsbeck Daniel , Wermann Michael , Jäger Christian , de Marco Alex , Schilling Stephan , Schlenzig Dagmar , Whisstock James C. 
Published: October 2022

AbstractThe zinc-dependent metalloprotease meprin α is predominantly expressed in the brush border membrane of proximal tubules in the kidney and enterocytes in the small intestine and colon. In normal tissue homeostasis meprin α performs key roles in inflammation, immunity, and extracellular matrix remodelling. Dysregulated meprin α is associated with acute kidney injury, sepsis, urinary tract infection, metastatic colorectal carcinoma, and inflammatory bowel disease. Accordingly, meprin α is the target of drug discovery programs. In contrast to meprin β, meprin α is secreted into the extracellular space, whereupon it oligomerises to form giant assemblies and is the largest extracellular protease identified to date (~6 MDa). Here, using cryo-electron microscopy, we determine the high-resolution structure of the zymogen and mature form of meprin α, as well as the structure of the active form in complex with a prototype small molecule inhibitor and human fetuin-B. Our data reveal that meprin α forms a giant, flexible, left-handed helical assembly of roughly 22 nm in diameter. We find that oligomerisation improves proteolytic and thermal stability but does not impact substrate specificity or enzymatic activity. Furthermore, structural comparison with meprin β reveal unique features of the active site of meprin α, and helical assembly more broadly.
Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical
Authors: Teng Kun-Xu , Niu Li-Ya , Xie Nan , Yang Qing-Zheng 
Published: October 2022

AbstractGiven that Type-I photosensitizers (PSs) have hypoxia tolerance, developing general approaches to prepare Type-I PSs is of great importance, but remains a challenge. Here, we report a supramolecular strategy for the preparation of Type-I photodynamic agents, which simultaneously generate strong oxidizing cationic radicals and superoxide radicals, by introducing electron acceptors to the existing Type-II PSs. As a proof-of-concept, three electron acceptors were designed and co-assembled with a classical PS to produce quadruple hydrogen-bonded supramolecular photodynamic agents. The photo-induced electron transfer from the PS to the adjacent electron acceptor occurs efficiently, leading to the generation of a strong oxidizing PS+•and an anionic radical of the acceptor, which further transfers an electron to oxygen to form O2−•. In addition, these photodynamic agents induce direct photocatalytic oxidation of NADH with a turnover frequency as high as 53.7 min−1, which offers an oxygen-independent mechanism to damage tumors.