bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postoperative ileus risk after posterior thoracolumbar fusion performed with total intravenous anesthesia versus inhaled anesthesia
Authors: Sherrod Brandon A. , Kim Robert , Hunsaker Joshua , Rada Courtney , Christensen Clint , Stoddard Gregory J. , Brodke Darrel , Mahan Mark A. , Mazur Marcus D. , Bisson Erica F. , Dailey Andrew T. 
Published: October 2022

OBJECTIVE
There has been an increase in the use of total intravenous anesthesia (TIVA) for intraoperative neuromonitoring during thoracolumbar posterior spinal fusion (PSF). Although prior studies have identified risk factors for postoperative ileus (PI) after PSF, to the authors’ knowledge, PI rates in patients receiving inhaled anesthetic versus TIVA have not been evaluated. In this study the authors analyzed whether TIVA is associated with greater risk of PI in PSF patients.

METHODS
In this retrospective single-institution cohort study, all patients undergoing PSF at the authors’ tertiary academic institution from May 2014 to December 2020 were included. Patients undergoing anterior/lateral approaches or who had concurrent abdominal procedures unrelated to ileus in the same admission were excluded. PI was defined using radiographic and/or clinical diagnoses (postoperative radiographs, abdominal CT, and/or ICD-9 or -10 codes) and was confirmed via chart review. The use of TIVA or inhaled anesthetic was captured from the anesthesia record; patients were excluded if they were missing anesthesia technique data. Postoperative occurrence of PI was compared between patients who had TIVA or inhaled anesthetics while controlling for collected demographic, clinical, and surgical variables.

RESULTS
Of the 2819 patients meeting inclusion criteria, 283 (10.0%) had PI (mean ± SD age 59.3 ± 15.8 years; 155 [54.8%] male). The mean patient length of stay was 7.7 ± 5.0 days, which was significantly longer than that of patients without PI (4.9 ± 3.9 days, p < 0.001). Patients with PI had more levels fused (46% of PI patients with ≥ 5 levels fused vs 25% of non-PI patients, p < 0.001) and longer operations (6.0 ± 2.2 vs 5.4 ± 1.9 hours, p < 0.001). TIVA patients were more likely than inhalation-only patients to experience PI, but this finding did not reach significance on univariate analysis (11.0% PI rate vs 8.9%, p = 0.06). After propensity matching 125 non-PI patients and 50 PI patients by age, sex, operative time, and number of levels fused, there was a significant difference in intraoperative opiate dosing between TIVA and inhalational patients (275.7 ± 187.5 intravenous morphine milligram equivalents vs 120.9 ± 155.5, p < 0.001). On multivariate analysis of PI outcome, TIVA was an independently significant predictor (OR 1.45, p = 0.02), as was anesthesia time (OR per hour increase: 1.09, p = 0.03) and ≥ 8 levels fused (OR 1.86, p = 0.01).

CONCLUSIONS
In a large cohort of PSF patients, TIVA was associated with a higher rate of PI compared with inhaled anesthetic. This effect is likely due to higher intraoperative opiate use in these patients.
Development of new postoperative neck pain at 12 and 24 months after surgery for cervical spondylotic myelopathy: a Quality Outcomes Database study
Authors: Sherrod Brandon A. , Michalopoulos Giorgos D. , Mulvaney Graham , Agarwal Nitin , Chan Andrew K. , Asher Anthony L. , Coric Domagoj , Virk Michael S. , Fu Kai-Ming , Foley Kevin T. , Park Paul , Upadhyaya Cheerag D. , Knightly John J. , Shaffrey Mark E. , Potts Eric A. , Shaffrey Christopher I. , Gottfried Oren N. , Than Khoi D. , Wang Michael Y. , Tumialán Luis M. , Chou Dean , Mummaneni Praveen V. , Bydon Mohamad , Bisson Erica F. 
Published: October 2022

OBJECTIVE
Patients who undergo surgery for cervical spondylotic myelopathy (CSM) will occasionally develop postoperative neck pain that was not present preoperatively, yet the incidence of this phenomenon is unclear. The authors aimed to elucidate patient and surgical factors associated with new-onset sustained pain after CSM surgery.

METHODS
The authors reviewed data from the Quality Outcomes Database (QOD) CSM module. The presence of neck pain was defined using the neck pain numeric rating scale (NRS). Patients with no neck pain at baseline (neck NRS score ≤ 1) were then stratified based on the presence of new postoperative pain development (neck NRS score ≥ 2) at 12 and 24 months postoperatively.

RESULTS
Of 1141 patients in the CSM QOD, 224 (19.6%) reported no neck pain at baseline. Among 170 patients with no baseline neck pain and available 12-month follow-up, 46 (27.1%) reported new postoperative pain. Among 184 patients with no baseline neck pain and available 24-month follow-up, 53 (28.8%) reported new postoperative pain. The mean differences in neck NRS scores were 4.3 for those with new postoperative pain compared with those without at 12 months (4.4 ± 2.2 vs 0.1 ± 0.3, p < 0.001) and 3.9 at 24 months (4.1 ± 2.4 vs 0.2 ± 0.4, p < 0.001). The majority of patients reporting new-onset neck pain reported being satisfied with surgery, but their satisfaction was significantly lower compared with patients without pain at the 12-month (66.7% vs 94.3%, p < 0.001) and 24-month (65.4% vs 90.8%, p < 0.001) follow-ups. The baseline Neck Disability Index (NDI) was an independent predictor of new postoperative neck pain at both the 12-month and 24-month time points (adjusted OR [aOR] 1.04, 95% CI 1.01–1.06; p = 0.002; and aOR 1.03, 95% CI 1.01–1.05; p = 0.026, respectively). The total number of levels treated was associated with new-onset neck pain at 12 months (aOR 1.34, 95% CI 1.09–1.64; p = 0.005), and duration of symptoms more than 3 months was a predictor of 24-month neck pain (aOR 3.22, 95% CI 1.01–10.22; p = 0.048).

CONCLUSIONS
Increased NDI at baseline, number of levels treated surgically, and duration of symptoms longer than 3 months preoperatively correlate positively with the risk of new-onset neck pain following CSM surgery. The majority of patients with new-onset neck pain still report satisfaction from surgery, suggesting that the risk of new-onset neck pain should not hinder indicated operations from being performed.
ОСОБЛИВОСТІ ФОРМУВАННЯ БРЕНДИНГУ ТЕРИТОРІЙ
Authors: Калініченко Сергій , Сподар Катерина , Грібіник Андрій , Холодок Валентина , Лагодієнко Володимир 
Published: October 2022

В умовах сучасного світу, нарівні з персональними й корпоративними брендами колосального значення віднедавна набуло поняття «бренд території». Суперництво міст, регіонів і країн за ресурси перетворює їх із географічних одиниць у повноцінні товари, що мають свою цінність, властивості, вартість. Тому в територій сформувалася потреба мати відмінну ідентичність і вміло про неї розповідати. Тепер мобільність людей, капіталу та ідей у світі інтенсивніша, ніж будь-коли раніше, тож лише за умов продуманого територіального маркетингу та брендингу територіальні громади мають можливість гідно конкурувати за ресурси, інвестиції, мешканців і партнерів. Території конкурують за створення найбільш привабливих умов проживання та ведення бізнесу. Фактично, глобальний ринок територій знаходиться в стадії активного формування: ті території, які першими почнуть використовувати філософію та інструменти брендингу для свого позиціонування та просування, будуть мати конкурентні переваги перед тими територіями, які не приділяють належної уваги розвитку своєї привабливості. Формування бренду території передбачає управління його створенням і просуванням, наявність замовника, кваліфікованої групи розробників, інформаційних і фінансових ресурсів, чітко сформульованого технічного завдання, програму створення і просування бренда, моніторинг його ефективності, визначення механізму його підтримки та розвитку
Imagem do pensamento: Deleuze e a filosofia da diferença
Authors: Grisotto Américo 
Published: October 2022

Este artigo tem a intenção indicar um uso propositivo da noção de imagem de pensamento presente na obra Diferença e repetição de Gilles Deleuze, pois de acordo com esta referência, é típico da repetição afirmar-se, permitindo a emergência do que difere. De outro modo, a noção de imagem do pensamento ocorre na filosofia de Deleuze em três ocasiões, nas obras Nietzsche e a filosofia, Proust e os signos e em Diferença e repetição e nestas obras, nem sempre esta perspectiva coincide, deslocando-se de um uso mais crítico para um uso mais positivo. Em termos estratégicos e metodológicos, é justamente sobre este último enfoque, de caráter construtivo, em que nos apoiaremos. A discussão gira em torno de uma imagem afirmativa do pensamento em filosofia face à diferença no ato da repetição, o que significa que a diferença em filosofia traria consigo, em seu movimento, um processo interno de diferenciação, cuja potência a repete, mas não da mesma forma, senão transmutando-a em outra possibilidade do que significa pensar.
The Impact of COVID-19 on Breast Cancer Treatment: A Systematic Review
Authors: Budiarta Michael , Brennan Meagan 
Published: October 2022

Background: During the COVID-19 pandemic, health resources were stretched, access was impacted by lockdowns and there were concerns about exposure to the virus during visits to hospitals. The purpose of this study was to examine how breast cancer treatments (presentation, surgery, radiotherapy, chemotherapy and/or endocrine therapy) changed or were adapted during the early phase of the pandemic.
Methods: A systematic review was conducted using PRISMA guidance. Eligible studies presented original data reporting changes to early breast cancer treatment by comparing ‘pandemic’ treatment to a ‘pre-pandemic’ cohort or to ‘ideal’ treatment of individual cases. Data were extracted into evidence tables and narrative synthesis was used to analyse results.
Results: Fifteen studies with paired design were eligible. These reported outcomes for 6,353 people treated for early breast cancer (January 2020–June 2021). All studies reported some change to treatment due to the pandemic. The nature of reported changes was inconsistent. Changes included: tumours more advanced at presentation compared to pre-pandemic, increase in breast conserving surgery; increase in simple mastectomy (without breast reconstruction); trend towards increased wait times, delays to start of treatment, shorter post-operative hospital stay and hypofractionation or omission of radiotherapy. Centres used more or less neoadjuvant chemotherapy or endocrine therapy.
Conclusion: In the early stage of the pandemic, fewer early-stage breast cancer cases were treated many centres. Treatment for breast cancer was impacted and various local solutions were developed. These included less complicated breast surgery, increased use of neoadjuvant therapy, and changes to radiotherapy regimens. Surgery was frequently delayed and breast reconstruction was often unavailable. These results have implications for breast cancer services during the pandemic recovery as a ‘catch-up’ increase in cancer diagnoses is expected. Women may wish to access breast reconstruction, unavailable due to COVID-19. The impact of changes to treatment on long-term quality of life should be evaluated.
STUDENTS’ PERCEPTION OF THE USE OF TED TALK VIDEOS IN PUBLIC SPEAKING CLASSS
Authors: Hidayati Istiqlaliah Nurul , Cahyani Shafira 
Published: October 2022

TED Talk videos contain speakers discussing the latest thinking about education, learning, innovation, etc. The videos are made as learning media in a public speaking class. This research investigates students’ perceptions of the use of TED Talks video in public speaking class. There were tirty five students contributing as participants of this research. To gain the research data, the researcher used three research instruments: questionnaire, students and lecturer interviews. According to the data analysis, it was found that both the students and lecturer in public speaking have similar perceptions of the use of TED Talk videos. It can be inferred that the use of TED Talk videos can enhance the students’ speaking performance and give new information to them. It is recommended that EFL classes can use TED Talk videos as authentic learning media.
Rancang bangun bobot kartesian tiga axis untuk penyiraman tanaman yang akurat dan efisien
Authors: Tamami Niam , Hermawan Hendhi , Hanafi Nofria , Madyono Madyono , Perdana Galang , Ramadhan Farhan 
Published: October 2022

Untuk menunjang lahan pertanian yang subur, diperlukan proses penyiraman agar kadar air dalam tanah tetap terjaga. Kegiatan penyiraman yang dilakukan secara manual membutuhkan banyak energi. Selain itu kadar air yang diberikan dengan penyiraman manual tidak dapat terukur secara akurat. Dalam makalah ini, kami mengusulkan penyiraman otomatis dengan robot kartesian tiga aksis untuk lahan dengan ukuran 3 meter x 1.5 meter dengan 171 titik tanam. Kontrol penyiraman berbasis fuzzy agar kadar air yang diberikan bisa akurat. Sebelum penyiraman, rata-rata kelembapan tanah pada lahan tersebut adalah 45.28% dengan nilai minimal 40%, nilai maksimal 50%. Target kelembapan tanah untuk setiap titik adalah 60%. Robot dapat menyiram seluruh titik tanam tanpa campur tangan manusia. Nilai kadar air rata-rata setelah penyiraman adalah 62.10%, dengan nilai minimal 60%, nilai maksimal 65%. Selain itu, juga telah dibandingkan mekanisme penyiraman dengan metode fuzzy dengan metode on-off, metode fuzzy mampu menghasilkan penyiraman yang lebih akurat dengan tingkat kesalahan rata-rata 2.10%, sedangkan metode on-off memiliki tingkat kesalahan rata-rata 5.32% terhadap target nilai kelembapan tanah. Metode fuzzy juga lebih efisien waktu dalam penyiraman yaitu 7 detik hingga 8 detik, sedangkan metode onoff membutuhkan waktu penyiraman 10 detik hingga 15 detik.

ABSTRACT
To support fertile agricultural land, a watering process is needed so that the water content in the soil is maintained. Watering activities carried out manually require a lot of energy. In addition, the water content given by manual watering cannot be measured accurately. In this paper, we propose automatic watering with a three-axis Cartesian robot for land with a size of 3 meters x 1.5 meters with 171 planting points. Fuzzy based watering control so that the water content given can be accurate. Before watering, the average soil moisture on the land was 45.28% with a minimum value of 40%, a maximum value of 50%. The target soil moisture for each point is 60%. The robot can water the entire planting point without human intervention. The average water content value of watering is 62.10%, with a minimum value of 60%, a maximum value of 65%. In addition, also compared with the application error with the fuzzy method with the on-offmethod, the fuzzy method is able to produce more accurate watering with an average error rate of 2.10%, while the on-off method has an average error of 5.32% against the soil moisture target. The fuzzy method is also more time efficient in watering, which is 7 seconds to 8 seconds, while the on-off method requires a watering time of 10 seconds to 15 seconds.
COG4 mutation in Saul-Wilson syndrome selectively affects secretion of proteins involved in chondrogenesis in chondrocyte-like cells
Authors: Xia Zhi-Jie , Mahajan Sonal , Paul Daniel Earnest James , Ng Bobby G. , Saraswat Mayank , Campos Alexandre Rosa , Murad Rabi , He Miao , Freeze Hudson H. 
Published: October 2022

Saul-Wilson syndrome is a rare skeletal dysplasia caused by a heterozygous mutation in COG4 (p.G516R). Our previous study showed that this mutation affected glycosylation of proteoglycans and disturbed chondrocyte elongation and intercalation in zebrafish embryos expressing the COG4p.G516R variant. How this mutation causes chondrocyte deficiencies remain unsolved. To analyze a disease-relevant cell type, COG4p.G516R variant was generated by CRISPR knock-in technique in the chondrosarcoma cell line SW1353 to study chondrocyte differentiation and protein secretion. COG4p.G516R cells display impaired protein trafficking and altered COG complex size, similar to SWS-derived fibroblasts. Both SW1353 and HEK293T cells carrying COG4p.G516R showed very modest, cell-type dependent changes in N-glycans. Using 3D culture methods, we found that cells carrying the COG4p.G516R variant made smaller spheroids and had increased apoptosis, indicating impaired in vitro chondrogenesis. Adding WT cells or their conditioned medium reduced cell death and increased spheroid sizes of COG4p.G516R mutant cells, suggesting a deficiency in secreted matrix components. Mass spectrometry-based secretome analysis showed selectively impaired protein secretion, including MMP13 and IGFBP7 which are involved in chondrogenesis and osteogenesis. We verified reduced expression of chondrogenic differentiation markers, MMP13 and COL10A1 and delayed response to BMP2 in COG4p.G516R mutant cells. Collectively, our results show that the Saul-Wilson syndrome COG4p.G516R variant selectively affects the secretion of multiple proteins, especially in chondrocyte-like cells which could further cause pleiotropic defects including hampering long bone growth in SWS individuals.
Impact of glucagon-like peptide 1 analogs on cognitive function among patients with type 2 diabetes mellitus: A systematic review and meta−analysis
Authors: Luan Sisi , Cheng Wenke , Wang Chenglong , Gong Jianhong , Zhou Jianbo 
Published: October 2022

BackgroundDiabetes is an independent risk factor for cognitive impairment. However, little is known about the neuroprotective effects of glucagon-like peptide 1 (GLP-1) analogs on type 2 diabetes mellitus (T2DM). Herein, we assessed the impact of GLP-1 analogs on the general cognitive functioning among patients with T2DM.MethodsRelevant studies were retrieved from PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov databases from their inception till June 30, 2022, without any language restrictions. For continuous variables, the mean and standard deviation (SD) were extracted. Considering the heterogeneity in general cognitive functioning assessments among the pooled studies, the standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs), were calculated.ResultsFive studies including 7,732 individuals with T2DM were selected for the meta-analysis. The use of GLP-1 analogs exerted no significant effects on the general cognitive functioning in self-controlled studies (SMD 0.33, 95% CI -0.03 to 0.69). Subgroup analyses among the self-controlled studies based on age and history of cardio-cerebrovascular disease showed that GLP-1 analogs significantly improved the general cognitive functioning in T2DM patients younger than 65 years (SMD 0.69, 95% CI 0.31 to 1.08) or those without cardio-cerebrovascular diseases (SMD 0.69, 95% CI 0.31 to 1.08). Similarly, differences in the general cognitive functioning for GLP-1 analogs between treated and non-treated patients with T2DM were significant in subgroups with patients younger than 65 years (SMD 1.04, 95% CI 0.61 to 1.47) or those with no history of cardio-cerebrovascular diseases (SMD 1.04, 95% CI 0.61 to 1.47).ConclusionLimited evidence suggests that the use of GLP-1 analogs exerts no significant effects on general cognitive functioning but may be beneficial for patients with T2DM younger than 65 years or those without a history of cardio-cerebrovascular diseases. Further prospective clinical studies with large sample sizes are needed to validate these findings.Systematic Review Registrationwww.inplasy.com, identifier 202260015.
Genetic risk variants for multiple sclerosis are linked to differences in alternative pre-mRNA splicing
Authors: Putscher Elena , Hecker Michael , Fitzner Brit , Boxberger Nina , Schwartz Margit , Koczan Dirk , Lorenz Peter , Zettl Uwe Klaus 
Published: October 2022

BackgroundMultiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system to which a genetic predisposition contributes. Over 200 genetic regions have been associated with increased disease risk, but the disease-causing variants and their functional impact at the molecular level are mostly poorly defined. We hypothesized that single-nucleotide polymorphisms (SNPs) have an impact on pre-mRNA splicing in MS.MethodsOur study focused on 10 bioinformatically prioritized SNP–gene pairs, in which the SNP has a high potential to alter alternative splicing events (ASEs). We tested for differential gene expression and differential alternative splicing in B cells from MS patients and healthy controls. We further examined the impact of the SNP genotypes on ASEs and on splice isoform expression levels. Novel genotype-dependent effects on splicing were verified with splicing reporter minigene assays.ResultsWe were able to confirm previously described findings regarding the relation of MS-associated SNPs with the ASEs of the pre-mRNAs from GSDMB and SP140. We also observed an increased IL7R exon 6 skipping when comparing relapsing and progressive MS patients to healthy subjects. Moreover, we found evidence that the MS risk alleles of the SNPs rs3851808 (EFCAB13), rs1131123 (HLA-C), rs10783847 (TSFM), and rs2014886 (TSFM) may contribute to a differential splicing pattern. Of particular interest is the genotype-dependent exon skipping of TSFM due to the SNP rs2014886. The minor allele T creates a donor splice site, resulting in the expression of the exon 3 and 4 of a short TSFM transcript isoform, whereas in the presence of the MS risk allele C, this donor site is absent, and thus the short transcript isoform is not expressed.ConclusionIn summary, we found that genetic variants from MS risk loci affect pre-mRNA splicing. Our findings substantiate the role of ASEs with respect to the genetics of MS. Further studies on how disease-causing genetic variants may modify the interactions between splicing regulatory sequence elements and RNA-binding proteins can help to deepen our understanding of the genetic susceptibility to MS.