bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indicators of the lipid composition of rat blood plasma under the action of ethylthiosulfanylate and chrome (VI) -induced toxicity
Authors:   nstitute of Animal Biology NAAS, Kotyk B. , Iskra R. ,   nstitute of Animal Biology NAAS
Published: February 2022

Ethylthiosulfanylate (ETS) is synthetic organosulfur compound and belongs to the class of thiosulfonates, which are the structural analogues of natural BACs of plant origin. Thiosulfonates and ETS in particular affect the regulation of pro/antioxidant status, lipid and protein metabolism in the tissues of laboratory rats. Cr(VI) compounds are characterized by potent prooxidant properties and high toxicity for cells of living organisms. The toxic effect of Cr(VI)-induced oxidative stress is accompanied by lipid metabolism disorders and the correction methods have not been sufficiently studied. The aim of our study was to investigate the effect of ETS on some indicators of lipid metabolism in blood plasma of rats under the action of K2Cr2O7-induced toxicity. Animals were divided into 7 groups. Animals of group I injected daily intraperitoneally with 150 μl of physiological solution for 7 days. Experimental groups III and IV were administered daily intraperitoneally with K2Cr2O7 in a dose of 2.5 mg Cr(VI)/kg body weight, for 7 (group III) and 14 days (group IV). Rats of group II received intragastric injection of 1000 μl of oil daily for 14 days, than animals were injected daily intraperitoneally with 150 μl of physiological solution for 7 days. Experimental group V was intragastrically injected with ETS oily solution at a rate of 100 mg/kg of body weight daily for 14 days, than animals were injected intraperitoneally 150 μl of physiological solution daily for 7 days. Animals of groups VI and VII were intragastrically administered with ETS oily solution at a rate of 100 mg/kg of body weight daily for 14 days, than animals were injected intraperitoneally daily K2Cr2O7 in a dose of 2.5 mg Cr(VI)/kg body weight, for 7 (group VI) and 14 days (group VII). Rats were decapitated under thiopental anesthesia, after which blood was taken and divided into erythrocytes and plasma. The Cr(VI) action for 7 (group III) and 14 days (group IV) led to an increase in the content of total lipids and triglycerides in the blood plasma of rats, but the percentage of nonesterified cholesterol decreased. ETS partially compensates the Cr(VI)-induced toxicity by reducing the intensity of total lipids (groups VI, VII) and triglycerides (group VI) accumulation.
A database of sequenced genomes of different Streptomyces albus J1074 strains and uses thereof
Authors:   Ivan Franko National University of Lviv, Dolya B. , Busche T. ,   CeBiTec, Bielefeld University, Jørgensen T. S. ,   The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark Kemitorvet, Ochi K. ,   Department of Life Sciences, Hiroshima Institute of Technology, Gren T. ,   The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark Kemitorvet, Weber T. ,   The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark Kemitorvet, Kalinowski J. ,   CeBiTec, Bielefeld University, Luzhetskyy A. ,   Department of Pharmacy, Saarland University, Ostash B. ,   Ivan Franko National University of Lviv
Published: February 2022

Streptomyces albus J1074 has recently emerged as a powerful chassis strain for natural product research and discovery, as well as model to investigate various aspects of actinobacterial biology. A number of genetic tools have been developed to facilitate the use of this strain for the aforementioned purposes. One of the promising approaches is to introduce into J1074 genome mutations that would improve the antibiotic-producing capacity of J1074. Particularly, we reported a collection of spontaneous and genomically engineered J1074 mutants carrying mutation in genes for ribosomal protein S12, RNA polymerase beta subunit etc. We took advantage of this collection to build an in-house database which would host (both current and future) the primary and curated sequencing data for these mutants. The database is available at https://biotools.online/media/. The main benefits of the database lie in the known pedigree of the strains, which allows deep interpretation of the data. For example, there is lively – and unresolved – debate on the origins and consequences of the GC composition in actinobacteria. A better understanding of this issue should improve our knowledge of genome evolution in bacteria and will have a number of biotechnological ramifications. We used our Streptomyces albus J1074 dataset as an experimental model to reveal genome-wide spectrum of mutation, which appears to be biased towards elevated GC content. We also included the high-quality genomes of the other streptomycetes into our databse for comparative purposes. The genomic GC content in streptomycetes varies from 75 % to 66.5 %, with median value being 72 %. The GC content of secondary metabolic genes of S. coelicolor is less variable than that of primary metabolic genes, an indicative of different selection pressure on these gene groups. Along with selective constraints, the peculiarities of Streptomyces DNA mismatch repair might contribute to the skewed GC content of their genomes. Further uses of the database may include the development of a more precise knowledge of the mutation rate as well as population genetic processes within this species and genus.
Effect of coal fly ash and potassium humate on nitrogen and carbon contents in coal industry dump substrate and organs of Sorghum drummondii (Nees ex Steud.) Millsp. & Chase
Authors:   Institute of Ecology of the Carpathian, Beshley S. , Baranov V. ,   Ivan Franko National University of Lviv, Shpak Y. ,   Ivan Franko National University of Lviv
Published: February 2022

Researched ammonium, nitrite and nitrate nitrogen and organic carbon contents in gray-black unburned rock substrate from coal industry waste rock dump of Central Enrichment Factory (CEF) owned by PJSC “Lviv Coal Company” (Lviv Oblast, Ukraine) and total nitrogen and organic carbon contents in organs of Sorghum drummondii (Nees ex Steud.) Millsp. & Chase under effect of coal fly ash from the Dobrotvir thermal power plant (Lviv Oblast, Ukraine) and potassium humate “ГКВ-45” (made by LLC “PARK”, Lviv Oblast, Ukraine). Found high content of organic carbon and ammonium nitrogen in waste rock dump substrate with contrast to low content of nitrite and nitrate nitrogen compare to re­latively optimal soil mixture of the standard. Detected low carbon and nitrogen contents in organs of S. drummondii which grew on the waste rock dump substrate, as well as a significantly increased carbon/nitrogen-ratio (in this research the ratio of organic carbon content to total nitrogen content) compare to plants of the standard. Addition of coal fly ash in waste rock dump substrate decreased ammonium nitrogen and organic carbon contents with contrast to nitrite and nitrate nitrogen increasing, as well as organic carbon and total nitrogen in roots, stalks and leaves of researched plants. Introduction of potassium humate increased nitrite and nitrate nitrogen contents in waste rock dump substrate, organic carbon and total nitrogen contents in organs of S. drummondii. Changing of both studied macronutrients contents in plants under the effect of ameliorants caused decreasing carbon/nitrogen-ratio to the direction of the standard values. Growing of S. drummondii grass for 95 days increased organic carbon content in all options of substrates except the rock with potassium humate addition and decreased ammonium, nitrite and nitrate nitrogen contents in all researched options of substrates without exceptions. Noted that combined effect of coal fly ash and potassium humate on carbon and nitrogen contents in waste rock dump substrate and organs of S. drummondii is stronger than just one of both above mentioned researched ameliorants.
Changes in zinc content in hippocampal neurons under stress reactions of different origin
Authors:   Zaporizhzhia State Medical University, Kuchkovskyi O. , Zadorozhnia V. ,   Zaporizhzhia National University, Belenichev I. ,   Zaporizhzhia State Medical University, Fedotov E. ,   Zaporizhzhia State Medical University, Sukhomlinova I. ,   Zaporizhzhia State Medical University, Monova A. ,   Zaporizhzhia State Medical University
Published: February 2022

It was shown in investigations on animals that injection of 8-(benzensulfonilamono)-quinoline (8-BSQ) in the dose 400 mg/kg was accompanied by the development in them epileptiform cramps and hippocampal intravitale reaction correlated with longing of cramps in animals. It’s intensity rose under animal stressing with physical load, immobilization, alcoholization. 8-BSQ microapplication into the hippocampus induced also the development of intravitale reaction and cramps in animals. Changes observed as a result of carried out work are explained by possibility of 8-BSQ of zinc chelating in hippocampus. The experiments used 167 mice, of which 107 mice received 8- (benzenesulfonylamino) -quinoline (8-BSQ) at a dose of 200 mg/kg, 37 mice were administered this convulsant at a dose of 400 mg/kg, and 23 mice were microapplied in hippocampus at a dose of 0.1 ml of 0.5 % solution of 8-BSQ. The analysis of the data, which is shown in this study once again supports the previously hypothesis of the role of zinc in the release of glutamic acid from the presynaptic plaque into the synaptic cleft. The complex of zinc with the chelating agent 8-BSQ affect the postsynaptic membrane thus sensitizing it. This, in turn, enhances the stimulating effect of glutamate on the postsynaptic membrane. This mechanism is accompanied not only by excessive release of glutamic acid due to the cleavage of zinc ions 8-BSQ, but also by additional sensitization of the postsynaptic membrane, which leads to increased activity of the hippocampus, up to clonic-tonic seizures. An acute pre-stress of animals through exercise, immobilization and alcoholism leads to a more pronounced intensity of the intravital reaction of 8-BSQ and to prolonged seizures. Previous administration of calcium and magnesium salts does not significantly affect the intensity of the intravital reaction and the duration of seizures in animals. And the present study elucidate that the intensity of the intravital reaction and the duration of seizures in mammals depend on the dose of the injected reagent. There is a direct relationship between the intensity of the intravital reaction and the duration of seizures in animals. Microapplication of caustic soda on which the 8-BSQ solution was prepared did not cause an intravital reaction and convulsions. These data indicate that the cause of seizures is the interaction of 8-BSQ with zinc in the neurons of the hippocampus.
Xanthine Oxidase Enzyme Inhibitory Effects of Combination Kumis Kucing (Orthosiphon aristatus L.) and Sidaguri Extract (Sida rhombifolia L.)
Authors: Fadilah Nitya Nurul 
Published: February 2022

Hyperuricemia is a high level of uric acid in the blood and can cause gout. One of the drugs used to treat hyperuricemia is allopurinol with a mechanism of inhibiting the activity of xanthine oxidase (XO). The use of these drugs can cause various side effects if used for a long period of time. Sidaguri and kumis kucing plants are known to contain flavonoids and are proven to treat gout with each plant can reduce uric acid levels in the blood and increase its excretion in urine. This study was carried out to test the combination of sidaguri and kumis kucing extracts with certain ratios in inhibiting the activity of the xanthine oxidase enzyme.
In this study, a combination of extracts was made using maceration method. The inhibition of xanthine oxidase activity by ethanol extract in vitro was determined by decreasing the production of uric acid monitored with a spectrophotometer at (λ) 292nm with xanthine as a substrate. Then determined the best IC50. As a comparison allopurinol is used.
Based on the results of in vitro tests, the best comparison of the combination of kumis kucing extract and sidaguri extract can inhibit the activity of XO enzymes with the best IC50 in a row is the combination of kumis kucing and sidaguri extracts 1:1 (20.99ppm), 1:2 (39.64ppm), and 1:0.5 (52.28ppm).
Ragam Pola Tabuhan Instrumen Gambang Pada Musik Gambang Semarang
Authors: Rachman Abdul , Teangtrong Pramot , Jirajaruphat Phakamas , Utomo Udi , Sinaga Syahrul Syah , Muchsin Ibnu Amar , Sokhiba Sabrina Firda 
Published: February 2022

Gambang Semarang merupakan salah satu musik tradisi Indonesia yang tumbuh dan berkembang di kota Semarang, Jawa Tengah. Musik Gambang Semarang memiliki instrumen yang terbuat dari kayu yang menjadi ciri khas dari musik Gambang Semarang itu sendiri yaitu Gambang. Instrumen Gambang memiliki ragam pola tabuhan khas yang bias memberi nuansa pada musik Gambang Semarang. Tujuan penelitian ini adalah untuk mengetahui dan mendeskripsikan ragam pola tabuhan instrumen Gambang pada musik Gambang Semarang. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan etnomusikologi. Teknik pengumpulan data dilakukan dengan teknik observasi, wawancara, studi dokumen, dan Focussed Group Discussion. Analisis data dilakukan dengan tahapan reduksi data, klasifikasi data, dan penyimpulan. Hasil penelitian menunjukkan bahwa pola tabuhan instrumen gambang pada musik Gambang Semarang terdiri dari pola tabuhan gembyang nglagu oktaf, dan pola garap cengkok ajeg. Masing-masing pola tabuhan dari instrumen gambang tersebut melibatkan rangkaian nada-nada sesuai dengan seleh-nya. Karena terpengaruh seleh dari melodi lagu utama maka pola tabuhan gembyang nglagu oktaf dan pola tabuhan garap cengkok ajeg memiliki enam seleh yaitu seleh do, seleh re, seleh mi, seleh sol, dan seleh la.
Monitoring of Regosol Soil Moisture with Internet of Things in Capilar Irrigation and Liquid Organic Fertilizer on Growth of Mustard Greens (Brassica rapa. L)
Authors: Saidi Didi , Charibaldi Novrido 
Published: February 2022

Regosol is soil that has a low level of soil fertility and water availability. According to internet of tings information system used to monitor soil moisture, water use will be more efficient. This study aims to apply the Internet of Things information system to monitor soil moisture in capillary irrigation and liquid organic fertilizer, study the capillary irrigation system and liquid organic fertilizer on the growth of mustard greens (Brassica rapa. L) and soil characteristics. The method used in this study was a completely randomized design (CRD) with two factors. namely Type of fertilizer, consisting of 4 levels, P0: No liquid organic fertilizer, P1: 5 liters/ha Household waste liquid organic fertilizer, P2: 5 liters/ha Biduri leaf liquid organic fertilizer, P3: 300 kg/ha NPK fertilizer. The second factor is the number of wick of capillary irrigation, consisting of 3 levels: I0: No capillary irrigation, I1: 1 wick capillary irrigation, I2: 2 wicks capillary irrigation. The results showed that the soil moisture during the growth of mustard greens was 16.59 to 23.48 %, the more capillary wicks, the higher the soil moisture. The average water requirement for mustard plant growth is 3.16 liters. Mustard plants begin to wither and lack water at 6.47 % soil moisture. Liquid organic fertilizer and capillary irrigation had a significant effect on leaf width, but had no significant effect on plant height, plant wet weight, plant dry weight, soil moisture, soil pH. Liquid organic fertilizer has a significant effect on soil C-organic and soil NPK levels, while capillary irrigation has a significant effect on water volume.
العلم والمعرفة مظهر من مظاهر الحضارة العربية الاسلامية
Authors: سلمان حمود محمد 
Published: February 2022

ملخص
يتحدث البحث عن دور العلم والمعرفة في الحضارة الإسلامية، ويظهر المكانة العظيمة التي حظي بها العلم والمعرفة في القران الكريم والسنة النبوية الشريفة، حتى أصبح العلم والمعرفة وجه من وجوة ومظاهر الحضارة العربية الإسلامية.
تكون البحث من مقدمة وثلاث مباحث وختم بقائمة المصادر والمراجع، تناول المبحث تفسير الحضارة العربية وما وصلت اليها من ازدهار، ثم يبين تعاريف وتوضيح للعلم والمعرفة، وجاء المبحث الثاني بمراحل الحركة العلمية الإسلامية، ثم المبحث الثالث بأهم العلوم التي بزغت بها شمس العرب العلمية والمعرفية، ثم قائمة المصادر.
الفاظ الاضطراب والاهتزاز في القرآن الكريم دراسة دلالية
Authors: صالح مهدي إيمان 
Published: February 2022

إن القرآن الكريم ميدان رحب وواسع لدراسة الألفاظ و دلالاتها الصوتية المتنوعة .وهو مشحون بألفاظ ذات دلالة خاصة سميت بألفاظ الاضطراب والاهتزاز تشعرك أصواتها بداهة بالحركة والاهتزاز ،فإذا تبينت معانيها اللفظية والسياقية تأكد ذلك المعنى (الانطباعي البدهي) وهو أمر سنثبته عن طريق استعراض طائفة واسعة من أقوال اللغويين والمفسرين في جملة كبيرة من تلك الألفاظ التي سنعالجها في فقرات بحثنا هذا وقد تعددت مبانيها فهي تارة مكررة المقطع وتارة مكررة الصوت الواحد وتارة على بناء معين مثل فعلل. وكل بناء مقصود في مكانه ويحمل دلالة خاصة لا ينفع تبديله بغيره ،وهذا من روائع البلاغة القرآنية .
Pemanfaatan Augmented Reality Dalam Membangun Sistem Informasi Pertanahan Pasca Pendaftaran Tanah Sistematik Lengkap
Authors: Ferdiansyah Dony Ferdiansyah , Wahyono Eko Budi , Widodo Sri 
Published: February 2022

Penyajian informasi kepada masyarakat di era keterbukaan informasi dan kemajuan teknologi pada revolusi industri 4.0 mengalami pertumbuhan yang sangat pesat dengan adanya media internet, sehingga dapat mengakses informasi lebih cepat dengan menggunakan smartphone. Kementerian ATR/BPN yang mengelola informasi tentang pertanahan, memiliki big data pertanahan yang besar pasca diadakannya kegiatan Pendaftaran Tanah Sistematik Lengkap sejak tahun 2017. Data tersebut harus mampu dikelola dengan baik untuk disajikan kepada masyarakat. Website berbasis WebGIS yaitu www.bhumi.atrbpn.go.id merupakan salah satu langkah dalam menyampaikan informasi pertanahan melalui tampilan pemetaan 2D. Masyarakat cukup kesulitan dalam membaca peta 2D. Hal ini menyebabkan informasi yang disajikan tidak tersampaikan dengan baik. Maka penelitian ini untuk melakukan rancang bangun aplikasi menggunakan teknologi augmented reality berbasis location-based service. Aplikasi tersebut akan dibangun melalui metode research and development dengan model prototyping. Informasi yang disajikan merupakan hasil superimposed dari dua layer yaitu persil bidang tanah dan informasi kepemilikan, jenis hak, NIB, penggunaan dan luas bidang tanah. Uji coba aplikasi tersebut dengan metode black box testing terhadap fungsionalitas aplikasi. Uji coba fungsionalitas aplikasi yang dibangun dilakukan oleh ASN dan PPNPN dari pegawai Kantor Pertanahan Kota Surabaya II dengan menyebarkan 14 pertanyaan melalui kuesioner tertutup. Hasil dari pengujian aplikasi adalah aplikasi dapat berfungsi dengan baik dan mampu menjadi salah satu sarana untuk menyajikan data pertanahan kepada masyarakat.
PENGARUH PERSEPSI NASABAH KREDIT USAHA RAKYAT (KUR) MENGENAI MANFAAT DAN KEUNGGULAN KREDIT USAHA RAKYAT (KUR) TERHADAP PENINGKATAN PENDAPATAN PADA PT. BANK RAKYAT INDONESIA (PERSERO) TBK, UNIT HANDIL BAKTI BARITO KUALA
Authors: Shintia Novi , Pratiwi Evi Lestari , Azwari Trisylvana 
Published: February 2022

Tujuan penelitian ini adalah untuk mempertahankan dan meningkatkan nasabah KUR BRI mencari tahu persepsi nasabah KUR mengenai manfaat dan keunggulan KUR BRI agar dapat menyesuaikan dengan keinginan nasabah guna memberikan kenyamanan kepada nasabah KUR BRI, dengan ini nasabah akan merasa nyaman dan senang menggunakan KUR BRI senantiasa memilih KUR BRI sebagai produk untuk penambahan modal usaha. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan variabel independen/terikat yaitu persepsi nasabah mengenai persepsi nasabah mengenai manfaat KUR BRI (X1) dan persepsi nasabah mengenai keunggulan KUR BRI (X2) berpengaruh secara simultan terhadap variabel dependen/terikat yaitu peningkatan pendapatan nasabah KUR BRI Unit Handil Bakti Barito Kuala.Sedangkan teknik analisis yang digunakan adalah analisis linier berganda. Dari hasil penelitian dapat diketahui bahwa variabel persepsi nasabah KUR BRI mengenai manfaat KUR BRI dan persepsi nasabah mengenai keunggulan KUR BRI tersebut berpengaruh terhadap pendapatan nasabah KUR BRI sebesar 24,9%. Sisanya sebesar 75,1% di pengaruhi oleh variabel lain yang bukan termasuk dalam penelitian ini. Kedua variabel bebas yaitu variabel persepsi nasbah mengenai persepsi nasabah mengenai manfaat KUR BRI (X1) dan persepsi nasabah mengenai keunggulan KUR BRI (X2) berpengaruh secara parsial / individual terhadap peningkatan pendapatan nasabah KUR BRI Unit Handil Bakti Barito Kuala. Dan variabel yang paling dominan berpengaruh terhadap peningkatan pendapatan nasabah KUR BRI dalam penelitian ini adalah variabel persepsi nasabah mengenai persepsi nasabah mengenai manfaat KUR BRI.
Pembelajaran Huruf Hijaiyah Dan Doa Harian Berbasis Aplikasi Android Di Taman Kanak-Kanak Mawaddah Banjarmasin
Authors: Dahrani Fitri Ani , Rahmah  , Rahma Pitria Ningsih  
Published: February 2022

Taman Kanak-kanak Mawaddah selama ini hanya menggunakan sistem belajar biasa dan cenderung cepat bosan dalam hal pembelajaran apalagi kalau sedang ada tugas di rumah sebagai latihan (pekerjaan rumah). Siswa juga sering tidak memperhatikan pada saat pembelajaran di kelas. Hal-hal tersebut yang mendorong pendidik menggunakan aplikasi android untuk dapat mengubah suasana pembelajaran menjadi lebih mudah dan tidak membosankan.
Penelitian ini dilakukan dengan menggunakan metode penelitian terapan, sumber data yang dikumpulkan meliputi data primer dan data sekunder, teknik pengumpulan data yaitu berupa wawancara, observasi, dan dokumentasi. Hasil penelitian ini adalah pembelajaran berbasi aplikasi android yang bertujuan untuk meningkatkan semangat belajar siswa, sehingga dapat dengan mudah memahami huruf hijaiyah dan doa harian.
A PERANCANGAN JALUR PEJALAN KAKI DI TEMPAT WISATA PANTAI RINDU ALAM
Authors: Misnawati Misnawati , Fachruzzaki Fachruzzaki , Erwaniansyah  
Published: February 2022

Pemerintah kabupaten Tanah Bumbu terus melakukan pembenahan infrastuktur dan fasilitas penunjang objek wisata untuk dijadikan sebagai destinasi wisata. Untuk itu diperlukan penelitian mengenai perencanaan fasilitas penunjang salah satunya perencanaan jalur pejalan kaki/pedestrian untuk menambah daya tarik wisata baik masyarakat lokal maupun luar daerah. Metode yang dilakukan dalam perencanaan adalah persiapan, pengumpulan data lapangan, mengolah data lapangan dan laporan hasil perencanaan. Hasil desain dari Perencanaan pembuatan jalur pejalan kaki/pedestrian daya tarik wisata Pantai Rindu Alam adalah panjang rencana pedestrian 201,5 m dan lebar 2 m. Pondasi yang digunakan ada 2 yaitu: pondasi poer plat setempat dan pasangan pondasi batu gunung. Selain pedestrian juga dibuat penunjang pedestrian seperti icon wisata, ornamen layar, dan kursi taman. Perencanaan jalur pejalan kaki/pedestrian Daya Tarik Wisata Pantai Rindu Alam ini merupakan bagian dari Perencanaan Pembuatan DED Wisata Pantai Rindu Alam.
UERGS: RASTROS DE UMA ARTE MICROPOLÍTICA DE (RE)EXISTÊNCIA
Authors: Flesch Jaqueline Madruga , Voss Dulce Mari da Silva 
Published: February 2022

Essa escrita traça rastros da arte de (re)existência da Universidade Estadual do Rio Grande do Sul (UERGS) ativada pelo compromisso ético-estético-político de defesa da educação pública e de qualidade social na campanha gaúcha. Por meio de um estudo de caso e da análise documental de dispositivos legais, institucionais e produção bibliográfica, guiada pela perspectiva pós-estruturalista, evidencia-se contingências macropolíticas em que forças neoliberais provocam a precarização do trabalho docente e impõem uma sobrevida às instituições públicas de educação superior em nosso país e região. Ao passo que, movimentos micropolíticos de uma maquinaria de guerra, posta em funcionamento no ensino, pesquisa e extensão, agem na contramão dessa ordem. É assim que a UERGS tem protagonizado a criação de sua paisagem existencial em aliança com movimentos sociais, instituições e sujeitos. Composição de forças e potências que possibilitam a reapropriação coletiva da pulsão vital.