bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fault mechanism analysis and diagnosis for closed-loop drive system of industrial robot based on nonlinear spectrum
Authors: Chen Lerui , Wen Shengjun , Wang Haiquan , Hu Heyu 
Published: November 2022

AbstractTo solve the problem of nonlinear characteristics neglecting and fault mechanism analysis lacking in fault diagnosis research, a new method of fault mechanism analysis and diagnosis based on nonlinear spectrum is proposed. Firstly, based on the Permanent Magnet Synchronous Motor (PMSM) model of robot, the first 4-order spectrums based on nonlinear output frequency response function (NOFRF) in different states are obtained by batch calculation method. Secondly, the high-frequency spectrum distribution rule of NOFRF spectrum in different states are analyzed. Finally, in the closed-loop simulation environment of robot, the identification method based on data-driven is adopted for NOFRF spectrum calculation to verify power loss fault of PMSM. Meanwhile, the fault diagnosis experiment is also carried out. The experimental results indicate that the key characteristics distribution rule of NOFRF spectrums in the real environment is consistent with the theoretical analysis results, and compared with the traditional fault feature extraction methods by output signal, the diagnosis with fault feature of NOFRF spectrum for industrial robot closed-loop drive system has the highest accuracy, which verifies the validity of NOFRF spectrum as the fault feature.
Physiological status and anatomical severity factors associated with child versus adult bicyclist fatalities based on a national trauma dataset
Authors: Ishii Wataru , Hitosugi Masahito , Kandori Kenji , Miyaguni Michitaro , Iizuka Ryoji 
Published: November 2022

AbstractBicyclists still account for the majority of child deaths in traffic accidents, despite a gradual decrease in incidence. Therefore, we investigated factors associated with child and adult bicyclist fatalities. In this retrospective study, we used data from a national hospital-based database, the Japan Trauma Data Bank. Data from 2004 to 2019 were obtained for child cyclists (5–18 years; n = 4832) and adult cyclists (26–45 years; n = 3449). In each age group, physiological variables, outcomes, and injury severity were compared between fatal and non-fatal cases. Multivariate logistic regression was performed to determine factors associated with fatality. In adults, fatality was associated with lower values for body temperature, Glasgow Coma Scale score, and Abbreviated Injury Scale (AIS) score for the neck and upper extremities, and with higher values for respiratory rate, heart rate, focused assessment with sonography for trauma positivity rate, and AIS scores for the head, chest, and abdomen. In children, fatality was associated with lower values for body temperature and the Glasgow Coma Scale score, and with higher values for the AIS chest score. These findings point to factors associated with bicyclist fatalities and may help in the development of effective strategies to reduce these fatalities.
Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis
Authors: Nagino Ken , Sung Jaemyoung , Oyama Genko , Hayano Motoshi , Hattori Nobutaka , Okumura Yuichi , Fujio Kenta , Akasaki Yasutsugu , Huang Tianxiang , Midorikawa-Inomata Akie , Fujimoto Keiichi , Eguchi Atsuko , Hurramhon Shokirova , Miura Maria , Ohno Mizu , Hirosawa Kunihiko , Morooka Yuki , Murakami Akira , Kobayashi Hiroyuki , Inomata Takenori 
Published: November 2022

AbstractWe investigated and characterized the prevalence of dry eye disease (DED) in Parkinson’s disease (PD). PubMed and EMBASE databases were searched for relevant studies between January 1, 1979 and March 10, 2022. Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Study-specific estimates were combined using the DerSimonian–Laird random-effects model. Prevalence of subjective DED symptoms in patients with PD and mean differences in blink rate, corneal thickness, tear film breakup time, and tear secretion volume on Schirmer test I were compared to those in controls. Of 383 studies, 13 (1519 patients with PD) and 12 were included in qualitative and quantitative syntheses, respectively. Meta-analysis revealed a 61.1% prevalence of subjective DED symptoms in PD and that, compared with controls, patients with PD had significantly lower blink rate, thinner corneal thickness, shorter tear film breakup time, and lower tear secretion volumes on Schirmer test I, without and with anesthesia.
Cytokines help suggest aplastic anemia with pulmonary bacterial or co-fungal infection
Authors: Zhang Jinping , Yang Zefeng , Hu Peng , Guan Xin , Zhang Chaoran , Zou Yunlian , Li Huiyuan , Yang Tonghua , Cao Yue , Zhao Renbin , Li Zengzheng 
Published: November 2022

AbstractAlthough aplastic anemia (AA) does not come under the category of blood malignant diseases, the infection that frequently occurs in this bone marrow failure can make it worse. Pulmonary infection is the most prevalent but limiting clinical diagnosis. To find biomarkers predicting bacterial or bacterial-combined fungal infections in the lungs, we reviewed 287 AA medical records including 151 without any infection, 87 with pure pulmonary bacterial infection, and 49 with bacterial and fungal infection were reviewed. There were substantial changes in IL-17F, IL-17A, IFN-γ, IL-6, IL-8, and IL-10 levels between the non-infected and lung bacterial infection groups (P < 0.05). Further, a significant variation in IL-17A, TNF-β, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-22, and IL-12p70, between the uninfected group and the pulmonary bacterial and fungal infection group (P < 0.05) was observed. The results further revealed significant differences in TNF-β, IL-12p70, IL-6, IL-8, and IL-10 between the pulmonary bacterial infection group and the fungal infection group (P < 0.05). Moreover, by calculating ROC and cut-off values, we determined that IL-6 (AUC = 0.98, Cut-off = 14.28 pg/ml, P = 0.0000) had a significant advantage than other cytokines, body temperature (AUC = 0.61, P = 0.0050), PCT (AUC = 0.57, P = 0.0592), and CRP (AUC = 0.60, P = 0.0147) in the detection of lungs bacterial infections. In addition, IL-6 (AUC = 1.00, Cut-off = 51.50 pg/ml, P = 0.000) and IL-8 (AUC = 0.87, Cut-off = 60.53 pg/ml, P = 0.0000) showed stronger advantages than other cytokines, body temperature (AUC = 0.60, P = 0.0324), PCT (AUC = 0.72, Cut-off = 0.63 ng/ml, P = 0.0000) and CRP (AUC = 0.79, Cut-off = 5.79 mg/l, P = 0.0000) in distinguishing bacteria from fungi. This may suggest that IL-8 may play a role in differentiating co-infected bacteria and fungi. Such advantages are repeated in severe aplastic anemia (SAA) and very severe aplastic anemia (VSAA).In conclusion, aberrant IL-6 elevations in AA patients may predict the likelihood of bacterial lung infection. The concurrent increase of IL-6 and IL-8, on the other hand, should signal bacterial and fungal infections in patients.These findings may help to suggest bacterial or fungal co-infection in patients with AA (Focus on VSAA and SAA).
Excess suicide attributable to the COVID-19 pandemic and social disparities in South Korea
Authors: Min Jieun , Oh Jieun , Kim Soo In , Kang Cinoo , Ha Eunhee , Kim Ho , Lee Whanhee 
Published: November 2022

AbstractThe impact of COVID-19 pandemic on suicide remains unclear and might differ according to individuals’ socioeconomic characteristics. We aimed to investigate excess suicide attributable to COVID-19 in South Korea, stratified by the outbreak period and individual characteristics. We obtained daily time-series suicide mortality data for January 2017–December 2020 from the Korea National Statistics Office and performed a two-stage interrupted time-series analysis. We estimated excess suicide in 16 regions of Korea using a quasi-Poisson time-series regression model and pooled the region-specific estimates using a mixed-effects multivariate meta-analysis model in the first and second stages, respectively. From February 18 to December 31, 2020, suicide decreased by 9.5% [95% empirical confidence interval (eCI): 3.8%, 15.6%] compared to the number expected from the pre-pandemic period. The decrease in excess suicide risk from the initial pandemic was pronounced during the pandemic’s first and third waves. Further, we found that the decrease in suicide was more evident in individuals who were male [11.7% (95% eCI: 5.5%, 18.0%)], middle-aged [13.7% (95% eCI: 7.8%, 19.6%)], highly educated [12.6% (95% eCI: 6.4%, 19.4%)], and married [13.6% (95% eCI: 8.0%, 20.3%)] than in the general population, based on the point estimates. Our results provide timely evidence to establish public health policies for suicide prevention and suggest the prioritization of resource allocation for mental health of individuals based on individual characteristics.
Health risk of consuming Sphoeroides spp. from the Navachiste Lagoon complex due to its trace metals and organochlorine pesticides content
Authors: Muñoz-Armenta Gabriela , Pérez-González Ernestina , Rodríguez-Meza Guadalupe Durga , González-Ocampo Hector Abelardo 
Published: November 2022

AbstractThe Navachiste complex (NAV) is impacted by neighbored human activities and is located in the southwestern coastal zone of the Gulf of California. The study determines the trace metal (TM) and organochlorine pesticides (OCP) health risk content in the edible tissue of Sphoeroides spp. from NAV. The daily intakes (EDI), target hazard quotient (THQ), hazard index (HI), and carcinogenic and non-carcinogenic risks were calculated. Twenty OCP and seven TM were detected. Cd, Cu, Fe, Mn, Pb, and Zn were above MRLs. The γ‒Chlordane was the most frequent OCP. The highest average concentration was for α‒HCH, followed by γ‒chlordane. With the high ratios of γ‒HCH, p, p′‒ DDD and p, p′‒DDD, and the absence of p, p′‒ DDT, the higher ratios for dieldrin and endrin than for aldrin, α‒ chlordane, γ‒chlordane, heptachlor, and heptachlor epoxide indicates historical contamination. In contrast, the residual products of methoxychlor, endosulfan, and its isomers indicate endosulfan's recent use. The TM EDI, THQ > 1 (at 120 g day−1), and the ILCR (> 1 × 10–6) were above minimum levels, showing a high-risk potential for cancer development in the long term.
Attractive and healthy-looking male faces do not show higher immunoreactivity
Authors: Pátková Žaneta , Schwambergová Dagmar , Třebická Fialová Jitka , Třebický Vít , Stella David , Kleisner Karel , Havlíček Jan 
Published: November 2022

AbstractPrevious research has indicated that facial attractiveness may provide cues to the functioning of the immune system. Mating with individuals who have a more effective immune system could lead to a higher reproductive success. Our main aim was to test a possible association between immunoreactivity (stimulated by vaccination) and perceived facial attractiveness and healthiness. We experimentally activated the immune system of healthy men using vaccination against hepatitis A/B and meningococcus and measured levels of specific antibodies (markers of immune system reactivity) before and 30 days after the vaccination. Further, 1 day before the vaccination, we collected their facial photographs that were judged by females for attractiveness, healthiness, and facial skin patches for healthiness. In view of its proposed connection with the functioning of the immune system, we also measured skin colouration (both from the facial photographs and in vivo using a spectrophotometer) and we assessed its role in attractiveness and healthiness judgements. Moreover, we measured the levels of steroid hormones (testosterone and cortisol) and the percentage of adipose tissue, because both are known to have immunomodulatory properties and are related to perceived facial attractiveness and healthiness. We found no significant associations between antibody levels induced by vaccination and perceived facial attractiveness, facial healthiness, or skin healthiness. We also found no significant connections between steroid hormone levels, the amount of adipose tissue, rated characteristics, and antibody levels, except for a small negative effect of cortisol levels on perceived facial healthiness. Higher forehead redness was perceived as less attractive and less healthy and higher cheek patch redness was perceived as less healthy, but no significant association was found between antibody levels and facial colouration. Overall, our results suggest that perceived facial attractiveness, healthiness, and skin patch healthiness provide limited cues to immunoreactivity, and perceived characteristics seem to be related only to cortisol levels and facial colouration.
Analysis of deviation from classical $$d_0^2$$-law for biochar conversion in an oxygen-enriched and temperature-controlled environment
Authors: Asheruddin N. Mohammed , Shivapuji Anand M. , Dasappa Srinivasaiah 
Published: November 2022

AbstractCombustion of char has conventionally been reported to be diffusion controlled. Analytically, the process is reported to follow second order initial diametric ($$d_0$$

d
0

) dependence $$(d_0^\beta ; \beta =2)$$

(

d
0
β

;
β
=
2
)

for both single-film (no CO combustion) and two-film models (CO burns in a concentric sphere over the particle). However, experimental investigations indicate deviation from classical diffusion limit with $$\beta$$
β
exceeding 2.00 and going as high as 2.37. Videography investigations depict luminous film engulfing the particle for certain Temperature-Oxygen concentration-Particle diameter combinations (for which, $$\beta \ge 2$$

β
≥
2

). The observed deviation is hypothesized to convective resistance offered by the CO generated on the surface to motion of $$CO_2$$

C

O
2

towards the surface. This results in reduced $$CO_2$$

C

O
2

concentration at the surface with enhanced conversion time being the implication (hence, $$\beta >2$$

β
>
2

). Such convective resistance remains unaccounted for in the prevailing analytical models. The CO dominated film thickness is enhanced with temperature and reactant concentration, increasing the convective resistance, and further deviating from $$d_0^2$$

d
0
2

behaviour. The analytical solution shows that in presence of a convectively expanding CO film, total conversion time is a function of film diameter while also being dependent on $$d_0^2$$

d
0
2

. The hypothesis is validated by comparing analytical estimates with experimentally observed film diameter and conversion time.
In vitro regeneration and its histological characteristics of Dioscorea nipponica Makino
Authors: Dang Shangni , Gao Runmei , Zhang Yuqing , Feng Yumei 
Published: November 2022

AbstractDioscorea nipponica Makino is an optimal candidate to develop the diosgenin industry in North China. Due to its increasing demand in the medicine industry, it is urgent to apply new biotechnological tools to foster breeds with desirable traits and enhanced secondary metabolite production. The production of useful metabolites by the in vitro cultured rhizomes can be explored successfully for utilization by various food and drug industries. In this study, we reported callus formation and plantlet regeneration of the medicinal plant D. nipponica. Explants of leaves, stem segments and rhizomes of aseptic seedlings were cultured on Murashige and Skoog (MS) medium containing various combinations of auxin and cytokinin to find the optimal PGRs of each type of explant for callus induction and shoot regeneration of D. nipponica. The paraffin section technique was also used to observe of the morphogenesis of callus and adventitious bud. Explants of seeds and rhizomes formed calli at high frequency in all lines we examined. However, the explant of leaves rarely formed callus. Three kinds of callus were detected during the induction phase. Here, we describe three types of callus (Callus I–III) with different structure characteristics. Greenish in color and a nodule-like protrusion surface (Callus type III) were arranged more closely of cells with less interstitial substance, cell differentiation ability stronger than other callus types. The optimum combination was the maximum shoot differentiation frequency of 90% in callus derived from seeds cultured on MS medium with 2.0 mg L−16-BA + 0.2 mg L−1NAA. The shoot differentiation frequency (88.57%) of rhizome-induced callus was obtained by the combination of MS medium supplemented with 3.0 mg L−16-BA + 2.0 mg L−1NAA. 1/2 MS medium plus 0.5 mg L−1NAA resulted in a higher root regeneration frequency of 86.70%. In vitro propagated plantlets with healthy roots were domesticated and transplanted into small plastic pots containing sterile soil rite under greenhouse conditions with 80% survivability. Bud differentiation is mostly of exogenous origin, mostly occurring on the near callus surface. Therefore, it may be surmised that in vitro morphogenesis of D. nipponica is mainly caused by indirect organogenesis (adventitious bud).
Comparative transcriptome and WGCNA reveal key genes involved in lignocellulose degradation in Sarcomyxa edulis
Authors: Duan Chao , Tian Feng-hua , Yao Lan , Lv Jian-Hua , Jia Chuan-Wen , Li Chang-Tian 
Published: November 2022

AbstractThe developmental transcriptomes of Sarcomyxa edulis were assessed to explore the molecular mechanisms underlying lignocellulose degradation. Six stages were analyzed, spanning the entire developmental process: growth of mycelium until occupying half the bag (B1), mycelium under low-temperature stimulation after occupying the entire bag (B2), appearance of mycelium in primordia (B3), primordia (B4), mycelium at the harvest stage (B5), and mature fruiting body (B6). Samples from all six developmental stages were used for transcriptome sequencing, with three biological replicates for all experiments. A co-expression network of weighted genes associated with extracellular enzyme physiological traits was constructed using weighted gene co-expression network analysis (WGCNA). We obtained 19 gene co-expression modules significantly associated with lignocellulose degradation. In addition, 12 key genes and 8 kinds of TF families involved in lignocellulose degradation pathways were discovered from the four modules that exhibited the highest correlation with the target traits. These results provide new insights that advance our understanding of the molecular genetic mechanisms of lignocellulose degradation in S. edulis to facilitate its utilization by the edible mushroom industry.
Drosophila ppk19 encodes a proton-gated and mechanosensitive ion channel
Authors: Jang Wijeong , Lim Ji Yeon , Kang Seyoung , Kim Minseok , Hwang Sun Wook , Kim Changsoo 
Published: November 2022

AbstractIn Drosophila larvae, nociceptive mdIV sensory neurons detect diverse noxious stimuli and prompt a nociceptive rolling response. Intriguingly, the same neurons also regulate stereotyped larval movement. The channels responsible for transducing these stimuli into electric signals are not yet fully identified. Here we undertook genetic and electrophysiological analysis of Ppk19, a member of the Deg/ENaC family of cationic channels. ppk19 mutants exhibited an impaired nociceptive rolling response upon mechanical force and acid, but no impairment in response to noxious temperature and gentle touch. Mutants also exhibited defective larval movement. RNAi against ppk19 in mdIV neurons likewise produced larvae with defects in mechanical and acid nociception and larval movement, but no impairment in detection of heat and gentle touch. Cultured cells transfected with ppk19 produced currents in acid and hypotonic solution, suggesting that ppk19 encodes an ion channel that responds to acid and cell swelling. Taken together, these findings suggest that Ppk19 acts in mdIV neurons as a proton- and mechano-gated ion channel to mediate acid- and mechano-responsive nociception and larval movement.
Fractional analysis of unsteady squeezing flow of Casson fluid via homotopy perturbation method
Authors: Qayyum Mubashir , Ahmad Efaza , Afzal Sidra , Sajid Tanveer , Jamshed Wasim , Musa Awad , Tag El Din El Sayed M. , Iqbal Amjad 
Published: November 2022

AbstractThe objective of this article is to model and analyze unsteady squeezing flow of fractional MHD Casson fluid through a porous channel. Casson fluid model is significant in understanding the properties of non-Newtonian fluids such as blood flows, printing inks, sauces and toothpaste etc. This study provides important results as unsteady flow of Casson fluid in fractional sense with aforementioned effects has not been captured in existing literature. After applying similarity transformations along with fractional calculus a highly non-linear fractional-order differential equation is obtained. Modeled equation is then solved along with no-slip boundary conditions through a hybrid of Laplace transform with homotopy perturbation algorithm. For validity purposes, solution and errors at various values in fractional domain are compared with existing results. LHPM results are better in terms of accuracy than other available results in literature. Effects of fractional parameter on the velocity profile, skin friction and behaviors of involved fluid parameters is the focal point of this study. Comprehensive, quantitative and graphical analysis is performed for investigating the effects of pertinent fluid parameters on the velocity profile and skin friction. Analysis revealed that fractional parameter depicts similar effect in case of positive and negative squeeze number. Also, skin friction decreases with an increasing fractional parameter. Moreover, in fractional environment Casson parameter has shown similar effect on the velocity profile in case of positive and negative squeeze number.
Discovery of four plasmatic biomarkers potentially predicting cardiovascular outcome in peripheral artery disease
Authors: Kremers B. M. M. , Posma J. N. , Heitmeier S. , Glunz J. , ten Cate H. , Pallares Robles A. , Daemen J. H. C. , ten Cate-Hoek A. J. , Mees B. M. E. , Spronk H. M. H. 
Published: November 2022

AbstractPeripheral artery disease (PAD) patients have an increased cardiovascular risk despite pharmacological treatment strategies. Biomarker research improving risk stratification only focused on known atherothrombotic pathways, but unexplored pathways might play more important roles. To explore the association between a broad cardiovascular biomarker set and cardiovascular risk in PAD. 120 PAD outpatients were enrolled in this observational cohort study. Patients were followed for one year in which the composite endpoint (myocardial infarction, coronary revascularization, stroke, acute limb ischemia and mortality) was assessed. Patient data and blood samples were collected upon inclusion, and citrated platelet-poor plasma was used to analyze 184 biomarkers in Olink Cardiovascular panel II and III using a proximity extension assay. Fifteen patients reached the composite endpoint. These patients had more prior strokes and higher serum creatinine levels. Multivariate analysis revealed increased plasma levels of protease-activated receptor 1 (PAR1), galectin-9 (Gal-9), tumor necrosis factor receptor superfamily member 11A (TNFRSF11A) and interleukin 6 (IL-6) to be most predictive for cardiovascular events and mortality. Positive regulation of acute inflammatory responses and leukocyte chemotaxis were identified as involved biological processes. This study identified IL-6, PAR1, Gal-9, TNFRSF11A as potent predictors for cardiovascular events and mortality in PAD, and potential drug development targets.