bluuebunny/crossref_metadata_2025_split huggingface dataset:
Propagation of antibiotic resistance genes during anaerobic digestion of thermally hydrolyzed sludge and their correlation with extracellular polymeric substances
Authors: Haffiez Nervana , Azizi Seyed Mohammad Mirsoleimani , Zakaria Basem S. , Dhar Bipro Ranjan 
Published: April 2022

AbstractThe positive impact of the thermal hydrolysis process (THP) of sewage sludge on antibiotic resistance genes (ARGs) removal during anaerobic digestion (AD) has been reported in the literature. However, little information is available on how changes in different extracellular polymeric substances (EPS) due to THP can influence ARG propagation during AD. This study focused on systematically correlating EPS components and ARG abundance in AD of sewage sludge pretreated with THP (80 °C, 110 °C, 140 °C, 170 °C). THP under different conditions improved sludge solubilization followed by improved methane yields in the biochemical methane potential (BMP) test. The highest methane yield of 275 ± 11.5 ml CH4/g COD was observed for THP-140 °C, which was 40.5 ± 2.5% higher than the control. Increasing THP operating temperatures showed a non-linear response of ARG propagation in AD due to the rebound effect. The highest ARGs removal in AD was achieved with THP at 140 °C. The multivariate analysis showed that EPS polysaccharides positively correlated with most ARGs and integrons, except for macrolides resistance genes. In contrast, EPS protein was only strongly correlated with β-lactam resistance genes. These results suggest that manipulating THP operating conditions targeting specific EPS components will be critical to effectively mitigating the dissemination of particular ARG types in AD.
Research on recognition and classification of pulse signal features based on EPNCC
Authors: Chen Haichu , Guo Chenglong , Wang Zhifeng , Wang Jianxiao 
Published: April 2022

AbstractTo rapidly obtain the complete characterization information of pulse signals and to verify the sensitivity and validity of pulse signals in the clinical diagnosis of related diseases. In this paper, an improved PNCC method is proposed as a supplementary feature to enable the complete characterization of pulse signals. In this paper, the wavelet scattering method is used to extract time-domain features from impulse signals, and EEMD-based improved PNCC (EPNCC) is used to extract frequency-domain features. The time–frequency features are mixed into a convolutional neural network for final classification and recognition. The data for this study were obtained from the MIT-BIH-mimic database, which was used to verify the effectiveness of the proposed method. The experimental analysis of three types of clinical symptom pulse signals showed an accuracy of 98.3% for pulse classification and recognition. The method is effective in complete pulse characterization and improves pulse classification accuracy under the processing of the three clinical pulse signals used in the paper.
Development and validation of questionnaire to assess exposure of children to enteric infections in the rural northwest Ethiopia
Authors: Gizaw Zemichael , Yalew Alemayehu Worku , Bitew Bikes Destaw , Lee Jiyoung , Bisesi Michael 
Published: April 2022

AbstractIn areas where children have multiple environmental exposures to enteric pathogens, identifying the sources of exposure by measuring external and internal exposures to enteric pathogens and complementing by questionnaire and observational checklist to capture behaviors resulting risk of exposure is critical. Accordingly, this study was conducted to design valid and reliable questionnaire to assess behaviors and environmental conditions resulting exposure to enteric pathogens in the rural northwest Ethiopia. We began with a thorough exploration of relevant literature to understand the theoretical framework on the research objectives to identify variables to highlight what the questionnaire is measuring. We then generated items in each domain that can effectively address the study objectives and we refined and organized the items in a suitable format. Then after, we conducted face and content validity by involving experts on the research subject. After pre-testing a pre-final version of the instrument generated in the content validity study, we conducted a pilot study in 150 randomly selected rural households to test the internal consistency reliability. We used content validity ratio (CVR), item-level content validity index (I-CVIs), scale-level content validity index (S-CVI/UA), and modified kappa statistics to measure content validity of items. Moreover, we used agreement and consistency indices (i.e., Cronbach’s alpha) to assess the internal consistency of items. The content validity test result showed that the value of CVR was 0.95, I-CVIs was 0.97, and modified kappa was 0.97 for the whole items, indicating all the items are appropriate. The scale-level content validity index (S-CVI/UA) was 0.95 for the whole items indicating the agreement among judges to each items is higher. The internal consistency reliability test result indicated that Cronbach’s alpha for the pre-final version of the pre-final tool was 0.85, indicating the strong reliability of the tool. The final version of the questionnaire was, therefore, prepared with 8 dimensions and 80 items. In this study, we designed valid and reliable questionnaire to assess behaviors and environmental conditions that result high risk of exposure to enteric infections in rural settings. The questionnaire can be used as a tool in the rural settings of developing countries with some amendments to account local contexts. However, this questionnaire alone does not measure exposure of children to enteric infections. It only complements external and internal exposure assessments.
L’Autre et l’Étranger dans la psychanalyse
Authors: Tyszler Jean-Jacques 
Published: April 2022

Comment ignorer aujourd’hui le sort tragique que nos mondes riches font aux migrants et aux exilés ? À quel prix le monde psychanalytique peut-il encore ignorer l’impact de telles réalités ?
Plutôt que de réciter à n’en plus finir des litanies sur le père, il faut situer aujourd’hui l’actualité urgente de ce que nous apprennent les exilés sur les logiques de survivance et de subjectivation.
Le transfert et la psychothérapie à l’épreuve d’un récit migrant : entre vérité et exactitude
Authors: Porto Carolina 
Published: April 2022

Cet article examine la question de la vérité dans le récit des patients en situation d’exil, ainsi que l’impact de la malléabilité de ce récit sur le transfert et sur le travail psychothérapeutique. Mettre des mots sur son histoire n’est pas seulement la raconter, mais aussi la créer et la comprendre. Le récit est une matière plastique, qui change rapidement et qui s’adapte ; il construit l’identité du sujet et, au cours de ce processus, est lui-même déconstruit et reconstruit plusieurs fois. C’est pour cela que le récit prend une place centrale dans le travail avec les patients issus de l’exil. À partir de la présentation du cas d’un enfant demandeur d’asile, suivi dans un centre médico-psycho-pédagogique, les questionnements de l’équipe soignante et le positionnement du psychologue y sont exposés. L’analyse de l’histoire de vie de la mère et de l’enfant, ainsi que des dessins du patient servent d’appui pour la présentation de ce cas. Leur récit « migrant », demande au thérapeute d’être capable de naviguer entre les notions de vérité et d’exactitude, pour pouvoir garder le cap du transfert. Le cas de ce patient démontre que la vérité demeure dans la rencontre faite avec chaque enfant, et dans le travail psychique effectué. Ce récit changeant, raconté au fil des années entre dessins, jeu et parole ; ce récit construit entre souvenirs et histoires confiées et entendues, c’est cela la vraie version de l’histoire de ce petit patient.
The Role of Herbal Medicine in Cholangiocarcinoma Control: A Systematic Review
Authors: Na-Bangchang Kesara , Plengsuriyakarn Tullayakorn , Karbwang Juntra 
Published: April 2022

AbstractThe growing incidence of cholangiocarcinoma (bile duct cancer) and limited treatment options stimulate a pressing demand for research and the development of new chemotherapeutics against cholangiocarcinoma. This study aimed to systematically review herbs and herb-derived compounds or herbal formulations that have been investigated for their anti-cholangiocarcinoma potential. Systematic literature searches were conducted in three electronic databases: PubMed, ScienceDirect, and Scopus. One hundred and twenty-three research articles fulfilled the eligibility critera and were included in the analysis (68 herbs, isolated compounds and/or synthetic analogs, 9 herbal formulations, and 119 compounds that are commonly found in several plant species). The most investigated herbs were Atractylodes lancea (Thunb.) DC. (Compositae) and Curcuma longa L. (Zingiberaceae). Only A. lancea (Thunb.) DC. (Compositae) has undergone the full process of nonclinical and clinical development to deliver the final product for clinical use. The extracts of A. lancea (Thunb.) DC. (Compositae), Garcinia hanburyi Hook.f. (Clusiaceae), and Piper nigrum L. (Piperaceae) exhibit antiproliferative activities against human cholangiocarcinoma cells (IC50 < 15 µg/mL). Cucurbitacin B and triptolide are herbal isolated compounds that exhibit the most promising activities (IC50 < 1 µM). A series of experimental studies (in vitro, in vivo, and humans) confirmed the anti-cholangiocarcinoma potential and safety profile of A. lancea (Thunb.) DC. (Compositae) and its active compounds atractylodin and β-eudesmol, including the capsule pharmaceutical of the standardized A. lancea (Thunb.) DC. (Compositae) extract. Future research should be focused on the full development of the candidate herbs to deliver products that are safe and effective for cholangiocarcinoma control.
Antibiotikaprophylaxe und empirische Antibiotikatherapie bei Primärendoprothetik und periprothetischen Gelenkinfektionen: Aktuelle Praxis und Bedarf an
Therapieoptimierung
Authors: Rupp Markus , Walter Nike , Baertl Susanne , Lang Siegmund , Herbst Tanja , Hitzenbichler Florian , Alt Volker 
Published: April 2022

ZusammenfassungDas Ziel der vorliegenden Arbeit ist es, die Versorgungssituation in Deutschland in Hinblick auf den Nutzen prophylaktischer und empirischer Antibiotikatherapie zu erheben. Unterschieden
wird zwischen primärer Endoprothetik und der Versorgung periprothetischer Gelenkinfektionen (PJI). Zu diesem Zweck wurde eine Umfrage in deutschen Universitätskliniken und BG-Kliniken
(Fachbereiche Orthopädie und/oder Unfallchirurgie) mittels Fragebogen durchgeführt. Die daraus resultierenden Umfragedaten wurden anschließend mit zuvor veröffentlichten Daten zur
antimikrobiellen Behandlung von n=81 PJI-Patienten, die zwischen 2017 und 2020 in unserer Abteilung behandelt wurden, verglichen.Hinsichtlich der prophylaktischen Antibiotikagabe im Kontext der Primärendoprothetik ergab sich ein homogenes Bild. In 93,2 % (elektiv) und 88,6 % (Frakturbehandlung) der Kliniken wurden
Cephalosporine der 1. und 2. Generation perioperativ zur Infektionsprophylaxe bei der primären Hüftendoprothetik verabreicht.Die empirische Verabreichung von Antibiotika bei PJI zeigte ein deutlich inhomogeneres therapeutisches Bild. Am häufigsten wird eine Monotherapie mit einem
Aminopenicillin/Betalaktamase-Inhibitor verordnet (38,7%); Cephalosporine der 1. und 2. Generation werden am zweithäufigsten im Rahmen einer Monotherapie eingesetzt (18,2%).Angesichts des globalen Problems der zunehmenden Antibiotikamultiresistenz muss der klinische Einsatz von Antibiotika sinnvoll und wirksam sein. Die vorliegenden Ergebnisse unterstreichen
die Notwendigkeit, das Bewusstsein hierfür zu schärfen und bestehende Leitlinien zur Verabreichung empirischer Antibiotikatherapie bei PJI zu beachten.
The Prevalence of BRAF, PIK3CA, and RAS Mutations in Indian Patients with Colorectal Cancer
Authors: Shetty Omshree , Vengurlekar Vaibhavi , Kapoor Akhil , Kamble Vishakha , Gurav Mamta , Bhargava Prabhat , Srinivas Sujay , Ramaswamy Anant , Ramadwar Mukta , Saklani Avanish P. , Desouza Ashwin , Ostwal Vikas 
Published: April 2022

Introduction The present study evaluates the mutation pattern and frequency of BRAF, PIK3CA and RAS in colorectal carcinoma observed in the tertiary cancer center in India.Materials and Methods Consecutive cases of colorectal adenocarcinoma (n = 330) registered from January 2015 to December 2019 (5-year duration) were selected for the study. Molecular analysis for BRAF.PIK3CA (exon 9 and 20) and RAS (KRAS&NRAS) was performed on representative formalin-fixed paraffin-embedded tissues by Sanger sequencing. Results were correlated with clinicopathological features. Patient overall survival (OS) was obtained using Kaplan–Meier method.Results The study cohort was in the age range of 22 to 81 years (median age: 52 years) that included 202 males and 96 females (male: female ratio 2.1:1). BRAF V600E mutation was observed in three cases (1%), while 17 cases (5.7%) had mutations in the PIK3CA gene (exon 9 or exon 20). Mutation analysis for RAS gene (KRAS&NRAS) was observed among 42 (15.4%) cases with KRAS mutation and 11 (4%) cases were positive for NRAS mutations. Among RAS, KRAS G12D was the predominant mutation. Median OS with wild-type RAS was 46.6 months (95% confidence interval [CI]: 22.4–70.8), while for RAS mutated patients, it was 25.6 months (95% CI: 16.7–34.5), hazard ratio: 1.7 (95% CI: 1.1–2.7, p = 0.025).Conclusion This study evaluated the prevalence of BRAF, PIK3CA and RAS mutations in the Indian cohort and its impact on clinical behavior. There was lower incidence of BRAF mutations in this cohort and PIK3CA mutation (single) did not impact survival of the patients.
History of Wrist Arthroscopy
Authors: Bain Gregory I. , Baker Andrew , Whipple Terry L. , Poehling Gary G. , Mathoulin Christophe , Ho Pak-Cheong 
Published: April 2022

AbstractWrist arthroscopy has a rich history, drawing on contributions from around the world. Its foundation was laid in Japan with Kenji Takagi and Masaki Watanabe, who developed the arthroscope and the techniques for arthroscopy. Across several decades they advanced the optic and lighting technology, allowing the miniaturization which made wrist arthroscopy technologically feasible. A safe and standardized technique for wrist arthroscopy was evolved by Terry Whipple, Gary Poehling, and James Roth in the 1980s, and they shared this with their fellow surgeons through courses and publications. The techniques then spread across the world, leading to widespread uptake and exploration of new therapeutic possibilities. The worldwide spread of wrist arthroscopy was accelerated by the European Wrist Arthroscopy Society (EWAS), founded in 2005 by Christophe Mathoulin. The Asia Pacific Wrist Association (APWA), founded by PC Ho in 2015, also extended the progression of wrist arthroscopy. This article brings together this history and tells the global story of its development through the recollections of those involved. The manuscript includes some amazing videos of the early historical arthroscopy. There are also videos of Gary and Terry describing some of their special memories of the early politics, developments, and evolution of wrist arthroscopy.
Dysregulated Expression of MiR-19b, MiR-25, MiR-17, WT1, and CEBPA in Patients with Acute Myeloid Leukemia and Association with Graft versus Host Disease after Hematopoietic Stem Cell Transplantation
Authors: Saadi Mahdiyar Iravani , Tahmasebijaroubi Fatemeh , Noshadi Esmat , Rahimikian Raha , Karimi Zahed , Owjfard Maryam , Niknam Ahmad , Abdolyousefi Ehsan Nabi , Salek Sanaz , Tabrizi Reza , Jamali Elham 
Published: April 2022

Objectives Acute myeloid leukemia (AML) is a blood malignancy characterized by the proliferation of aberrant cells in the bone marrow and blood that interfere with normal blood cells. We have investigated whether changes in the level of micro-ribonucleic acid (miR)-19b, miR-17, and miR-25, Wilms' tumor (WT1), and CCAAT enhancer-binding protein α (CEBPA) genes expression affect disease prognosis and clinical outcome in AML patients.
Materials and Methods The expression level of miR-19-b, miR-17, and miR-25, as well as WT1 and CEBPA genes in a group of patients and controls as well as different risk groups (high, intermediate, and favorite risk), M3 versus non-M3, and graft-versus-host disease (GvHD) versus non-GvHD patients were assessed using a quantitative SYBR Green real-time polymerase chain reaction method.
Results When compared with the baseline level at the period of diagnosis before chemotherapy, the expression of miR-19b and miR-17 in AML patients increased significantly after chemotherapy. The level of miR-19b and miR-25 expression in AML patients with M3 and non-M3 French–American–British subgroups differ significantly. MiR-19b and miR-25 expression was elevated in GvHD patients, while miR-19b and miR-25 expression was somewhat decreased in GvHD patients compared with non-GvHD patients, albeit the difference was not statistically significant. Also, patients with different cytogenetic aberrations had similar levels of miR-19-b and miR-25 expression.
Conclusion MiR-19b, miR-17, and miR-25 are aberrantly expressed in AML patients' peripheral blood leukocytes, which may play a role in the development of acute GvHD following hematopoietic stem cell transplantation.
Serum Free Light Chain Assay as a Prognostic Marker in Patients with Aggressive B-Cell Non-Hodgkin's Lymphoma: Impact on Survival Outcome
Authors: Anoop T.M. , Narayanan Geetha , Chacko Steffi , Krishna K.M. Jagathnath , Nair Sreejith G. 
Published: April 2022

Background The role of serum free light chain (FLC) as a prognostic biomarker in lymphoproliferative diseases is being increasingly studied. In this study we present the 5-year survival outcome for patients with aggressive B-cell non-Hodgkin's lymphoma (NHL) and their relation to FLC and other known prognostic markers.
Materials and Methods This is a prospective study conducted in patients diagnosed with aggressive B-cell NHL. Serum FLC level and ratio were estimated prior to initiation of treatment.
Results A total of 100 patients were included in the study from December 2013 to December 2015 with a median age of 53 years. Thirty-eight patients (38%) had elevated FLC level of which 26% were polyclonal and 12% were monoclonal elevations. Abnormal FLC ratio was noted in 12% patients. Median follow-up duration of the study was 75 months. Five-year relapse-free survival (RFS) for the study population was 54.4%. Five-year RFS was 64.1% for early stage and 48.2% for advanced stage diseases (p = 0.05). The RFS was significantly better in age less than 60 years (59.5% vs 43.8%, p < 0.001). Five-year overall survival (OS) was 61.3%. OS was significantly better in younger patients (73.6% vs 33.4%, p < 0.001), with International Prognosis Index score of 0 to 2 (87.4% vs 26.7%, p < 0.001). Patients with elevated FLC had inferior RFS (50% vs 71.4%, p = 0.04). Abnormal FLC ratio also strongly corresponded to inferior RFS (54.5% vs 66.2%, p = 0.001). OS was also significantly inferior in patients with abnormal FLC ratio (72.6% vs 63.6%, p = 0.001).
Conclusion In patients with newly diagnosed aggressive B-cell NHL, elevated FLC levels and abnormal FLC ratio were significantly associated with inferior survival.
A model of mechanics of growing solids for the stress-strain analysis of wound composites reinforced with thin unidirectional fibers
Authors: Kazakov K E , Parshin D A 
Published: April 2022

Abstract
A mathematical model of the mechanics of growing solids has been developed that allows us to retrace the elastic stress-strain state progressing for cylindrical composites in the process of their slow layer-by-layer manufacturing by force winding of elementary material layers reinforced with sufficiently thin fibers in the circumferential direction, with an arbitrary density of their laying and an arbitrary pre-tension force. The obtained analytical relationships enable to set different control problems for a composite layer being formed including those for the characteristics of its contact interaction with the mandrel used.
On the influence of the pipe outer coating nonuniformity on the contact stresses arising under rigid bushes
Authors: Kazakov K E 
Published: April 2022

Abstract
The work is devoted to the formulation and construction of a solution in analytical form for the mechanical problem of contact interaction between a finite system of rigid cylindrical bushes and a pipe with an external coating, which has longitudinal nonuniformity. In industry and mechanical engineering, the presence of such additional coatings is required, for example, for protection the pipe main layer from external aggressive media, for its electrical or thermal insulation, etc. The nonuniformity of such a layer may be due to various additional requirements, as well as the obtaining process of this layer. When analyzing the stress-strain state of the pipe interacting with the bushes, it is necessary to take into account all the features. The paper shows that the mathematical model of the above-described interaction problem is a system of mixed integral equations containing integral operators of different types. Moreover, the resulting system includes functions describing the variable properties of the outer layer in the area of interaction with the bushings. The special approach described by the main theses in this paper makes it possible to obtain a solution in a form in which all complex functions are allocated as separate multipliers. This makes it possible to perform calculations even in cases where the coating is highly heterogeneous or consists of different materials.
Temperature field measurements between a Bunsen flame and flat a cold plate by using PLIF
Authors: Tolstoguzov R V , Chikishev L M 
Published: April 2022

Abstract
The present experimental work reports on the temperature measurements in a Bunsen flame, covered by a flat cooled plate from the top. The temperature field is measured based on the planar laser-induced fluorescence method for hydroxyl radical (OH) during the excitation of excitation Q1(8) line of the (1-0) band of the A2Σ+-X2Π electronic system. Thermometry was based on the imaging of the ratio of the fluorescence intensity for the band (2-0) and bands (0-0), (1-1). The paper presents the obtained temperature fields for the distances between the plate and the burner of 1, 2 and 3 calibres. The paper also concludes that the used method can be implemented using a single-pulse laser illumination and is effective for the detection of cold zones.
Statistical analysis of operational data of the GTS-LHC ion source
Authors: Küchler D , Mihailescu M 
Published: April 2022

Abstract
The GTS-LHC ECR ion source delivers ion species for the physics programme of the CERN accelerator complex. Stability and reproducibility are key parameters for a successful operation. Therefore the source requires regularly intervention by an expert. The integrated functionality of data logging in the control system of the CERN accelerator complex allows to store all relevant control values and beam properties for the different machines. For the years 2015, 2016 and 2018, the data for the lead ion operation of the GTS-LHC ion source were extracted from the logging and treated with various statistical methods to identify recurring patterns in the operational settings of the source. If such patterns exist, they may be used in the future for the control of the source by semi-automatic feedback loops. The main study performed was based on a cluster analysis using the Optigrid algorithm, which is well suited for problems with a high number of parameters. The algorithm and selected results considering some operational aspects and ideas on further studies are presented.