bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combination of MRI‐Guided High‐Intensity Focused Ultrasound and Bioluminescent Biological Systems to Assess Thermal Therapies for Tumor and Tumor Microenvironment
Authors: Jeanjean Pauline , El Hamrani Dounia , Genevois Coralie , Quesson Bruno , Couillaud Franck 
Published: January 2022

AbstractThis work presents an integrated technology for assessing in vivo anticancer treatments in mice, based on various heating conditions. Bioluminescence imaging (BLI) is used to assess the physiological response of tumor and tumor microenvironment (TME) to heat treatment induced by magnetic resonance‐guided high‐intensity focused ultrasound (MRgHIFU). Transgenic tumor cells and mouse models with either constitutive or thermo‐induced luciferase expressions are combined to monitor cell viability and heat‐induced processes in the tumor and TME. BLI performed after MRgHIFU heating shows that a moderate increase in temperature (45 °C) over 5 min can be exploited to promote heat‐activable treatments in the tumor and its TME, without inducing direct cell death. A higher temperature rise over a shorter exposure time can induce cell death in the tumor, as revealed by a reduction in the BLI signal after treatment. Under these conditions, BLI also reveals that the TME can be stimulated by heat without inducing necrosis. These integrated technologies and models are useful to assess, in vivo in mice, the efficacy of various anticancer strategies exploiting local heat deposition by noninvasive MRgHIFU, including those combining tumor ablation with local drug administration using thermosensitive nanovehicles.
Compressive Space Dynamics Manipulation Enabling Wearable Fiber Sensors for Highly Sensitive Human Micromotion Monitoring
Authors: Ke Longwei , Liu Jinhua , Hu Yunfeng , Zhang Xiaomin , Zhang Xiaopei , Wang Yisha , Luo Yan , Wang Wenqing , Yan Yan , Lin Huijuan , Rui Kun , Zhu Jixin , Zhu Yi 
Published: January 2022

AbstractWearable electronic devices have received much attention for their potential applications in soft robotics, human‐machine interaction, and human motion detection. Herein, a high‐performance wearable fiber sensor is constructed for monitoring human micromotion by enabling compressive space dynamics manipulation. The developed sensor depends on the porous microstructure of vanadium pentoxide@ reduced graphene oxide fiber and endows it high sensitivity in sensing. Importantly, the sensor still presents a similar porous structure compared with the initial state even after thousands of repeated bending‐releasing cycles, ensuring a long‐term stability. Furthermore, the synergistic effect of multiple fibers can broaden the detection range and further improve the sensitivity. Consequently, the assembled multi‐fiber sensor exhibits a high sensitivity (a gauge factor value of 245.1) and an excellent stability (4000 cycles). Finally, these sensors are successfully applied to monitor small‐scale human movements, showing tremendous potential as wearable electronics.
Bortezomib‐Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy
Authors: Chen Mingyu , Juengpanich Sarun , Li Shijie , Topatana Win , Lu Ziyi , Zheng Qiang , Cao Jiasheng , Hu Jiahao , Chan Esther , Hou Lidan , Chen Jiang , Chen Fang , Liu Yu , Jiansirisomboon Sukanda , Gu Zhen , Tongpeng Suparat , Cai Xiujun 
Published: January 2022

AbstractGallbladder cancer (GBC) is a rare but the most malignant type of biliary tract tumor. It is usually diagnosed at an advanced stage and conventional treatments are unsatisfactory. As a proteasome inhibitor, bortezomib (BTZ) exhibits excellent antitumor ability in GBC. However, the long‐term treatment efficacy is limited by its resistance, poor stability, and high toxicity. Herein, BTZ‐encapsulated pH‐responsive copolymeric nanoparticles with estrone (ES‐NP(BTZ; Ce6)) for GBC‐specific targeted therapy is reported. Due to the high estrogen receptor expression in GBC, ES‐NP(BTZ; Ce6) can rapidly enter the cells and accumulate near the nucleus via ES‐mediated endocytosis. Under acidic tumor microenvironment (TME) and 808 nm laser irradiation, BTZ is released and ROS is generated by Ce6 to destroy the “bounce‐back” response pathway proteins, such as DDI2 and p97, which can effectively inhibit proteasomes and increase apoptosis. Compared to the traditional treatment using BTZ monotherapy, ES‐NP(BTZ; Ce6) can significantly impede disease progression at lower BTZ concentrations and improve its resistance. Moreover, ES‐NP(BTZ; Ce6) demonstrates similar antitumor abilities in patient‐derived xenograft animal models and five other types of solid tumor cells, revealing its potential as a broad‐spectrum antitumor formulation.
Aorta Regulatory T Cells with a Tissue‐Specific Phenotype and Function Promote Tissue Repair through Tff1 in Abdominal Aortic Aneurysms
Authors: Li Jingyong , Xia Ni , Li Dan , Wen Shuang , Qian Shirui , Lu Yuzhi , Gu Muyang , Tang Tingting , Jiao Jiao , Lv Bingjie , Nie Shaofang , Hu Desheng , Liao Yuhua , Yang Xiangping , Shi Guoping , Cheng Xiang 
Published: January 2022

AbstractIn addition to maintaining immune tolerance, Foxp3+ regulatory T cells (Tregs) perform specialized functions in tissue homeostasis and remodeling. However, whether Tregs in aortic aneurysms have a tissue‐specific phenotype and function is unclear. Here, a special group of Tregs that potentially inhibit abdominal aortic aneurysm (AAA) progression are identified and functionally characterized. Aortic Tregs gradually increase during the process of AAA and are mainly recruited from peripheral circulation. Single‐cell TCR sequencing and bulk RNA sequencing demonstrate their unique phenotype and highly expressed trefoil factor 1 (Tff1). Foxp3cre/creTff1flox/flox mice are used to clarify the role of Tff1 in AAA, suggesting that aortic Tregs secrete Tff1 to regulate smooth muscle cell (SMC) survival. In vitro experiments confirm that Tff1 inhibits SMC apoptosis through the extracellular signal‐regulated kinase (ERK) 1/2 pathway. The findings reveal a tissue‐specific phenotype and function of aortic Tregs and may provide a promising and novel approach for the prevention of AAA.
A Shift from Efficiency to Adaptability: Recent Progress in Biomimetic Interactive Soft Robotics in Wet Environments
Authors: Fang Jielun , Zhuang Yanfeng , Liu Kailang , Chen Zhuo , Liu Zhou , Kong Tiantian , Xu Jianhong , Qi Cheng 
Published: January 2022

AbstractResearch field of soft robotics develops exponentially since it opens up many imaginations, such as human‐interactive robot, wearable robots, and transformable robots in unpredictable environments. Wet environments such as sea and in vivo represent dynamic and unstructured environments that adaptive soft robots can reach their potentials. Recent progresses in soft hybridized robotics performing tasks underwater herald a diversity of interactive soft robotics in wet environments. Here, the development of soft robots in wet environments is reviewed. The authors recapitulate biomimetic inspirations, recent advances in soft matter materials, representative fabrication techniques, system integration, and exemplary functions for underwater soft robots. The authors consider the key challenges the field faces in engineering material, software, and hardware that can bring highly intelligent soft robots into real world.
Achieving Uniform Li Plating/Stripping at Ultrahigh Currents and Capacities by Optimizing 3D Nucleation Sites and Li2Se‐Enriched SEI
Authors: Cao Jiaqi , Xie Yonghui , Yang Yang , Wang Xinghui , Li Wangyang , Zhang Qiaoli , Ma Shun , Cheng Shuying , Lu Bingan 
Published: January 2022

AbstractLithium (Li) has garnered considerable attention as an alternative anodes of next‐generation high‐performance batteries owing to its prominent theoretical specific capacity. However, the commercialization of Li metal anodes (LMAs) is significantly compromised by non‐uniform Li deposition and inferior electrolyte–anode interfaces, particularly at high currents and capacities. Herein, a hierarchical three‐dimentional structure with CoSe2‐nanoparticle‐anchored nitrogen‐doped carbon nanoflake arrays is developed on a carbon fiber cloth (CoSe2–NC@CFC) to regulate the Li nucleation/plating process and stabilize the electrolyte–anode interface. Owing to the enhanced lithiophilicity endowed by CoSe2–NC, in situ‐formed Li2Se and Co nanoparticles during initial Li nucleation, and large void space, CoSe2–NC@CFC can induce homogeneous Li nucleation/plating, optimize the solid electrolyte interface, and mitigate volume change. Consequently, the CoSe2–NC@CFC can accommodate Li with a high areal capacity of up to 40 mAh cm–2. Moreover, the Li/CoSe2–NC@CFC anodes possess outstanding cycling stability and lifespan in symmetric cells, particularly under ultrahigh currents and capacities (1600 h at 10 mA cm−2/10 mAh cm−2 and 5 mA cm−2/20 mAh cm−2). The Li/CoSe2–NC@CFC//LiFePO4 full cell delivers impressive long‐term performance and favorable flexibility. The developed CoSe2–NC@CFC provides insights into the development of advanced Li hosts for flexible and stable LMAs.
Highly Efficient and Stable Iridium Oxygen Evolution Reaction Electrocatalysts Based on Porous Nickel Nanotube Template Enabling Tandem Devices with Solar‐to‐Hydrogen Conversion Efficiency Exceeding 10%
Authors: Nam Yungi , Kim Daehan , Chu Jinwoo , Park Na‐Yeon , Kim Tae Gun , Kim Kyung Joong , Kim Soo‐Hyun , Shin Byungha 
Published: January 2022

AbstractIr is one of the most efficient oxygen evolution reaction (OER) catalysts; however, it is also one of the rarest and most expensive elements. Therefore, it is highly desirable to develop Ir catalysts with nanostructures that reduce Ir consumption by maximizing the surface‐to‐volume ratio without limiting the mass transport of reactants and products of reactions. Ir OER catalysts on a template that consisted of porous nanotubes (PNTs) based on Ni are fabricated. The Ir/Ni PNTs offer multiple benefits, including high catalytic performance (potential of 1.500 V vs. reversible hydrogen electrode (RHE) at an operating current density of 10 mA cm−2 and Tafel slope of 44.34 mV decade−1), minimal use of Ir (mass activity of 3273 A g−1 at 1.53 V vs RHE), and facile mass transport through the NT‐sidewall pores (stable operation for more than 10 h). The Ir/Ni PNTs are also applied to a tandem device, consisting of a Cu(In,Ga)Se2‐based photocathode and halide perovskite photovoltaic cell, for unassisted water splitting. A solar‐to‐hydrogen conversion efficiency that exceeded 10% is also demonstrated, which is nearly 1% point greater than when a planar Ir film is used as the anode instead of Ir/Ni PNTs.
Highly Efficient and Stable CsPbTh3 (Th = I, Br, Cl) Perovskite Solar Cells by Combinational Passivation Strategy
Authors: Wang Kang , Ma Simin , Xue Xiaoyang , Li Tong , Sha Simiao , Ren Xiaodong , Zhang Jingru , Lu Hui , Ma Jinfu , Guo Shengwei , Liu Yucheng , Feng Jiangshan , Najar Adel , Liu Shengzhong (Frank) 
Published: January 2022

AbstractThe distorted lead iodide octahedra of all‐inorganic perovskite based on triple halide‐mixed CsPb(I2.85Br0.149Cl0.001) framework have made a tremendous breakthrough in its black phase stability and photovoltaic efficiency. However, their performance still suffers from severe ion migration, trap‐induced nonradiative recombination, and black phase instability due to lower tolerance factor and high total energy. Here, a combinational passivation strategy to suppress ion migration and reduce traps both on the surface and in the bulk of the CsPhTh3 perovskite film is developed, resulting in improved power conversion efficiency (PCE) to as high as 19.37%. The involvement of guanidinium (GA) into the CsPhTh3 perovskite bulk film and glycocyamine (GCA) passivation on the perovskite surface and grain boundary synergistically enlarge the tolerance factor and suppress the trap state density. In addition, the acetate anion as a nucleating agent significantly improves the thermodynamic stability of GA‐doped CsPbTh3 film through the slight distortion of PbI6 octahedra. The decreased nonradiative recombination loss translates to a high fill factor of 82.1% and open‐circuit voltage (VOC) of 1.17 V. Furthermore, bare CsPbTh3 perovskite solar cells without any encapsulation retain 80% of its initial PCE value after being stored for one month under ambient conditions.
Autonomous Visualization of Damage in Polymers by Metal‐Free Polymerizations of Microencapsulated Activated Alkynes
Authors: Han Ting , Chen Shusheng , Wang Xinnan , Fu Xinyao , Wen Haifei , Wang Zaiyu , Wang Dong , Qin Anjun , Yang Jinglei , Tang Ben Zhong 
Published: January 2022

AbstractThe development of autonomous materials with desired performance and built‐in visualizable sensing units is of great academic and industrial significance. Although a wide range of damage indication methods have been reported, the “turn‐on” sensing mechanism by damaging events based on microcapsule systems, especially those relying on chemical reactions to elicit a chromogenic response, are still very limited. Herein, a facile and metal‐free polymerization route with an interesting reaction‐induced coloration effect is demonstrated. Under the catalysis of 1,4‐diazabicyclo[2.2.2]octane (DABCO), the polymerizations of difunctional or trifunctional activated alkynes proceed very quickly at 0 °C in air. A series of polymers composed of stereoregular enyne structure (major unit) and divinyl ether structure (minor unit) are obtained. Both the catalyst and monomers are colorless while the polymerized products are deep‐colored. This process can be applied for the damage visualization of polymers using the microencapsulation technique. Microcapsules containing the reactive alkyne monomer are prepared and mixed in a DABCO‐dispersed polymer film. Both the external and internal damage regions of this composite film can be readily visualized once the reaction is initiated from the ruptured microcapsules. Moreover, the newly formed polymer automatically seals the cracks with an additional protection function.
Performance and pressure drop ofCO2absorption into task‐specific and halide‐free ionic liquids in a microchannel
Authors: Ma Daofan , Zhu Chunying , Fu Taotao , Ma Youguang , Yuan Xigang 
Published: January 2022

AbstractThe gas–liquid two‐phase flow pattern, absorption rate and pressure drop of CO2absorbed into the aqueous solution of the task‐specific ionic liquids (1‐aminopropyl‐3‐methylimidazole tetrafluoroborate [Apmim][BF4] and 1‐hydroxyethyl‐3‐methylimidazole tetrafluoroborate [OHemim][BF4]) and halide‐free ionic liquid 1‐butyl‐3‐methylimidazolium methylsulfate [Bmim][CH3SO4] were investigated in a microreactor. The absorption mechanism of the three ionic liquids was analyzed employing the13C NMR spectroscopy. The [Apmim][BF4] was found to have the best ability of CO2capture compared with the other two ionic liquids, as chemical absorption occurred between [Apmim][BF4] and CO2, while only physical absorption took place between [OHemim][BF4]/[Bmim][CH3SO4] and CO2. The sequence of CO2absorption rate in three ionic liquids aqueous solutions is: [Apmim][BF4] > [Bmim][CH3SO4] > [OHemim][BF4]. Furthermore, the effects of gas–liquid flow rate and ionic liquids concentration on CO2absorption rate and pressure drop were studied, the pressure drop models based on various flow patterns were proposed.
Capturing the effects of particle heterogeneity on adsorption in a fixed bed
Authors: Pollard Zoe A. , Cannon Andrew , Ryan Emily M. , Goldfarb Jillian L. 
Published: January 2022

AbstractTo efficiently design new adsorption systems, industrial scale fixed beds are often scaled down to bench‐top experiments and/or modeled using computational fluid dynamics (CFD). While there has been considerable work exploring adsorption of volatile organics onto activated carbon fixed beds in the literature, this article attempts to reckon with the high variability of adsorption capacities observed at small scales and improve small‐scale experiments for industrial scale reactor design. This study integrates experimental results with CFD simulations, which can explicitly model system heterogeneities and their influence on adsorption by resolving local packing densities and flow paths. Activated carbon physical properties were determined through surface area analysis, proximate analysis, and toluene adsorption (measured via mass spectroscopy). Variability in the small‐scale systems was not attributed to surface area or carbon content, as is often stated, but instead was due to local packing density variations and the heterogeneity of particle size distributions.
Dominance and social interaction patterns in brown capuchin monkey (Cebus [Sapajus] apella) social networks
Authors: Gazes Regina Paxton , Schrock Allie E. , Leard Corinne N. , Lutz Meredith C. 
Published: January 2022

AbstractStrong, stable social bonds in primates are characterized by high levels of social affiliation, low levels of aggression, minimal stress, and affiliative reciprocity within the dyad. In relatively well‐studied catarrhine monkeys, these bonds tend to form most frequently between kin, animals close in age, and animals close in rank. This results in patterns of affiliation in which kin, similarly aged animals, and like‐ranked animals tend to affiliate and patterns of aggression and submission where animals tend to aggress more toward nonkin and closely ranked animals, and submit more toward distantly ranked animals. However, literature on how affiliative and agonistic relationships are organized in platyrrhine primate species like brown capuchin monkeys is limited and conflicting. In this study, we used social network analyses to characterize how age, sex, maternal kinship, and dominance rank relate to the patterns of submissive, aggressive, contact, and grooming interactions in a group of captive brown capuchin monkeys. Like catarrhine monkeys, brown capuchin monkeys showed a steep linear dominance hierarchy, tended to affiliate with kin, similarly aged animals, and like‐ranked animals, and tended to aggress more toward nonkin. However, our monkeys showed a pattern of affiliation and grooming down the hierarchy that is inconsistent with grooming up the hierarchy patterns often seen in catarrhine monkey groups, suggesting that brown capuchins do not compete for access to higher ranking social partners. Higher ranking monkeys were most central to the aggression network, and lower ranking monkeys were most central to the submission network. Mid‐ranking monkeys were the most central to the contact network, suggesting that they may play an important role in the affiliative cohesion of the group. These results inform our understanding of brown capuchin social behavior specifically, and of how demographic factors relate to social organization in platyrrhine primates generally.
Cortical Correlates of Gait Compensation Strategies in Parkinson Disease
Authors: Tosserams Anouk , Weerdesteyn Vivian , Bal Tess , Bloem Bastiaan R. , Solis‐Escalante Teodoro , Nonnekes Jorik 
Published: January 2022

ObjectiveGait impairment in persons with Parkinson disease is common and debilitating. Compensation strategies (eg, external cues) are an essential part of rehabilitation, but their underlying mechanisms remain unclear. Using electroencephalography (EEG), we explored the cortical correlates of 3 categories of strategies: external cueing, internal cueing, and action observation.MethodsEighteen participants with Parkinson disease and gait impairment were included. We recorded 126‐channel EEG during both stance and gait on a treadmill under 4 conditions: (1) uncued, (2) external cueing (listening to a metronome), (3) internal cueing (silent rhythmic counting), and (4) action observation (observing another person walking). To control for the effects of sensory processing of the cues, we computed relative power changes as the difference in power spectral density between walking and standing for each condition.ResultsRelative to uncued gait, the use of all 3 compensation strategies induced a decrease of beta band activity in sensorimotor areas, indicative of increased cortical activation. Parieto‐occipital alpha band activity decreased with external and internal cueing, and increased with action observation. Only internal cueing induced a change in frontal cortical activation, showing a decrease of beta band activity compared to uncued gait.InterpretationThe application of compensation strategies resulted in changed cortical activity compared to uncued gait, which could not be solely attributed to sensory processing of the cueing modality. Our findings suggest there are multiple routes to control gait, and different compensation strategies seem to rely on different cortical mechanisms to achieve enhanced central motor activation in persons with Parkinson disease. ANN NEUROL 2022;91:329–341
Inverse Vulkanisierung von Norbornenylsilanen: Lösliche Polymere mit kontrollierbaren molekularen Eigenschaften durch Siloxanbindungen
Authors: Scheiger Johannes M. , Hoffmann Maxi , Falkenstein Patricia , Wang Zhenwu , Rutschmann Mark , Scheiger Valentin W. , Grimm Alexander , Urbschat Klara , Sengpiel Tobias , Matysik Jörg , Wilhelm Manfred , Levkin Pavel A. , Theato Patrick 
Published: January 2022

AbstractBei der inversen Vulkanisation werden Polymere mit hohem Schwefelgehalt aus Alkenen und elementarem Schwefel hergestellt. Die Kontrolle über Eigenschaften wie die Molmasse oder die Löslichkeit der Polymere ist nicht etabliert. Bestehenden Strategien mangelt es an Vorhersagbarkeit oder sie erfordern große Variationen der Zusammensetzung der Polymere. Systematische Prinzipien zur Variation der Polymereigenschaften sind daher gesucht, um eine gezielte Materialentwicklung zu ermöglichen. Wir berichten über die inverse Vulkanisation von Norbornenylsilanen (NBS) mit einer unterschiedlichen Anzahl hydrolysierbarer Gruppen am Siliziumatom. Die inverse Vulkanisation von NBS‐Mischungen mit anschließender Polykondensation ergab lösliche Copolymere mit hohem Schwefelgehalt (50 Masse‐% S) und mit kontrollierbarer mittlerer Molmasse (MW), Polydispersität (Đ), Glasübergangstemperatur (TG) oder Null‐Scher‐Viskosität (η0). Die Polykondensation wurde in der Schmelze mit HCl als Katalysator durchgeführt, so dass kein Lösungsmittel erforderlich war. Die Reinigung durch Fällung ergab Polymere mit stark reduziertem Anteil an niedermolekularen Spezies.
Dynamic Timing Control over Multicolor Molecular Emission by Temporal Chemical Locking
Authors: Zong Zezhou , Zhang Qi , Qiu Shu‐Hai , Wang Qian , Zhao Chengxi , Zhao Cai‐Xin , Tian He , Qu Da‐Hui 
Published: January 2022

AbstractDynamic control over molecular emission, especially in a time‐dependent manner, holds great promise for the development of smart luminescent materials. Here we report a series of dynamic multicolor fluorescent systems based on the time‐encoded locking and unlocking of individual vibrational emissive units. The intramolecular cyclization reaction driven by adding chemical fuel acts as a chemical lock to decrease the conformational freedom of the emissive units, thus varying the fluorescence wavelength, while the resulting chemically locked state can be automatically unlocked by the hydrolysis reaction with water molecules. The dynamic molecular system can be driven by adding chemical fuels for multiple times. The emission wavelength and lifetime of the locking states can be readily controlled by elaborating the molecular structures, indicating this strategy as a robust and versatile way to modulate multi‐color molecular emission in a time‐encoded manner.