bluuebunny/crossref_metadata_2025_split huggingface dataset:
SLX5 deletion confers tolerance to oxidative stress in Saccharomyces cerevisiae
Authors: Thomas Pınar B , Kaluç Nur , Aybastıer Önder 
Published: August 2022

Abstract
Slx5, a subunit of a SUMO-targeted ubiquitin ligase (STUbL) in yeast, has been implicated in maintenance of genomic stability. SUMOylation is an important post-translational modification involved in the regulation of several important cellular processes and cellular response to various environmental stressors. Oxidative stress occurs when production of reactive oxygen species (ROS) exceeds the antioxidant defense capacity of the cell. Elevated ROS levels cause oxidative damage to important cellular macromolecules such as DNA, lipids, and proteins, which is associated with several diseases. Herein, we investigated the role of Slx5 in oxidative stress tolerance in Saccharomyces cerevisiae. We show that deletion of SLX5 increases survival of yeast cells in response to H2O2-induced oxidative stress in a cell cycle independent manner. Accumulation of intracellular ROS as well as DNA and lipid damages were reduced; expressions of antioxidant defense mechanism-related genes were increased in slx5Δ cells compared to wild type (WT) under oxidative stress. We also show that slx5Δ cells have increased intracellular ROS levels and oxidative damage to DNA and lipids compared to WT in the absence of oxidative stress. Thus, our data together suggest that an adaptive stress induced by SLX5 deletion increases tolerance to oxidative stress in slx5∆ cells.
Dementia and Sexuality: A Story of Continued Renegotiation
Authors: Claes Frauke , Enzlin Paul 
Published: August 2022

AbstractThis article presents a new conceptual framework that shows how dementia may affect the sexual relationship between partners, and how different actors become progressively more involved in “managing” the sexual relationship during consecutive phases of dementia, that is, the premorbid, preclinical, and clinical phases. Each phase challenges couples in different ways and these challenges may affect the expression of sexuality in their relationship. The person living with dementia and/or the partner’s desire to continue to be sexually active may result in conflicts with health care professionals and family members who want to protect the person living with dementia from becoming the perpetrator and/or the victim of “inappropriate” or “harming” sexual behavior. The framework posits that a diagnosis of dementia instigates a journey of renegotiating sexuality in which gradually more actors—who often approach sexuality from a sex-negative point of view—become involved. Therefore, the new framework starts from a sex-positive perspective and is presented together with a new research agenda that ensues from this framework. Research based on this framework that starts from the experience of both people living with dementia and their partners will help us to better understand the relational and sexual effects of a dementia diagnosis. This knowledge will enable health care professionals to provide tailored care with respect for the sexual needs of couples living with dementia. Hence, clinical implications arising from the framework are presented.
Refusing the Colonial Discourse of Animality: Insects, Farmworkers, and Ecological Solidarity in Helena María Viramontes’ Under the Feet of Jesus
Authors: Fink Lisa 
Published: August 2022

Abstract
This article explores the role of insects in Helena Maria Viramontes’ 1995 novel Under the Feet of Jesus. Drawing on decolonial theory and critical animal studies, it argues that the novel refuses the colonial discourse of animality, thereby offering a vision of ecological solidarity between farmworkers and insects. Close readings of insects demonstrate how the novel witnesses the mutual precarity of farmworkers and insects, as well as their collective resilience, in the landscape of US industrial agriculture. In this way, Viramontes’ novel presents an environmental imaginary that challenges the linked logics of human exceptionalism and white supremacy.
Dietary effects of aucubin on growth and flesh quality of grass carp (Ctenopharyngodon idellus) based on metabolomics
Authors: Xu Zhen , Yang Hang , Li Xiaoqin , Xu Xiaoying , Tan Hongxin , Leng Xiangjun 
Published: August 2022

Abstract
This aim of this study was to investigate the effects of dietary aucubin on the growth, flesh quality, and metabolomics of grass carp (Ctenopharyngodon idella). Five diets were designed with the aucubin inclusion of 0 (control diet), 0.2, 0.4, 0.6, and 0.8 g/kg (Auc-0.2, Auc-0.4, Auc-0.6, Auc-0.8) and were fed to grass carp with an initial body weight of 17.0 ± 0.2 g for 60 d. The results indicated that dietary aucubin did not significantly affect the growth performance of grass carp (P &gt; 0.05). Compared to the control, dietary supplementation with 0.2 to 0.8 g/kg aucubin increased flesh hardness, chewiness, the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and the contents of total free amino acids (TFAA) and n-3 polyunsaturated fatty acids (n-3 PUFA) (P &lt; 0.05). The contents of malondialdehyde (MDA) and lactic acid (LD) in the flesh were significantly decreased by the addition of 0.4 to 0.6 g/kg aucubin and by the addition of 0.6 to 0.8 g/kg aucubin (P &lt; 0.05), respectively, while the content of delicious amino acids (DAA) was significantly enhanced by the addition of 0.4 to 0.8 g/kg aucubin (P &lt; 0.05). Moreover, the contents of collagen and C22:6n3 (DHA) in the flesh of the Auc-0.8 group were significantly higher than those of the control (P &lt; 0.05). In the metabolomics profiling of flesh, 133 and 135 named differential metabolites were identified in the Auc-0.4 and Auc-0.8 groups, respectively, compared to the control, and these metabolites were found to be involved in the second-grade pathways of “lipid metabolism” and “amino acid metabolism”. Regarding gene expression, the mRNA levels of CuZn-SOD, CAT, COL1A1, COL1A2, Smad4, and FAS in flesh were upregulated in the Auc-0.4 and Auc-0.8 groups, and the expression levels of GPx, Nrf2, and TGF-β1 mRNA were also upregulated in the Auc-0.8 group (P &lt; 0.05). In summary, dietary aucubin did not promote growth, but improved the flesh quality of grass carp, which might be associated with the TGF-β/Smad and Nrf2 pathways. The recommended supplementation level of aucubin in the diet of grass carp was 0.6 to 0.8 g/kg.
A False-Positive Gamma-Hydroxy Butyric Acid Urine Screening in a Patient with High Anion Gap Metabolic Acidosis Due to Ethylene Glycol Poisoning
Authors: Steels Sophie , De Bont Erika , Verbinnen Margo , Van den Eede Nele , Pauwels Steven 
Published: August 2022

Abstract
A young woman with a history of several suicide attempts was admitted to the hospital after suspicion of a new intoxication without definite identification of the causing agent. The patient had a high anion gap metabolic acidosis (HAGMA) with respiratory compensation, a lactate gap and an osmolar gap at admission. Initial toxicological screening showed no abnormalities except for a weak positive gamma-hydroxy butyric acid (GHB) enzymatic screen in urine. This finding could not be confirmed using chromatographic analysis nor be explained by the presence of known cross-reacting substances like ethanol. In this case, falsely elevated urinary GHB screening was caused by the ingestion of ethylene glycol. To confirm that the interference was due to ethylene glycol or its metabolites, we performed a spiking experiment. Cross reactivity was linked to ethylene glycol and was low in our experiments (0.1–0.2%). Substantial amounts of ethylene glycol are required to slightly elevated GHB results, depending on the endogenous cutoff used. We can conclude that ethylene glycol can give rise to falsely elevated urinary GHB levels at ethylene glycol concentrations that are typically found in intoxications.
Unravelling of the Number 16 in Corporeality, Percussion, and the Bengali Hindu Cosmos: The Experience of the Body/Mṛdaṅga
Authors: Sarbadhikary Sukanya 
Published: August 2022

AbstractThis paper analyses how the body and sacred drum, mṛdaṅga—used as the rhythm-accompaniment of Bengal’s devotional music dedicated to deities, Rādhā–Kṛṣṇa (kīrtana)—are cultivated and experienced as homologous, mirror-reflections of a macrocosmic sonic buzz, Nāda-brahman. Dimensions of cosmic/acoustic transcendence and its materialising potential as the body and instrument are explored through the number 16. 16 is analysed as an unfolded, expanded expression of what Yoga texts describe as the unstruck drone, AUM̐, or Nāda-brahman, composed of 3½ (4-fold) parts, exactly like the Tantric kuṇḍalinī, spiralled as the feminine, sonic power at the spinal base. I argue that these Yogic, Tantric, and devotional ontologies come together in Bengal’s mahā-mantra: 16 nāma (names) 32 akṣara (syllables), or Hare Kṛṣṇa chant, which practitioners say, constitute both the body and mṛdaṅga. Based on decade-long ethnographic work with Bengal Vaiṣṇavas, and mṛdaṅga’s makers, players, and sound meditators, studying expert techniques, oral traditions of esoteric poems and myths relating the body–mṛdaṅga as mirroring agents, and through philosophy of sound readings in Yoga and Tantra, I argue that the meditative body’s transcendental potential is analogous with mṛdaṅga’s sounding. Both these vessels are constituted through various classifications of number 16: evident in the body’s/drum’s constructions, breathing, rhythming, tonality, and being. The body becomes the drum and vice-versa, and these resonant vessels throb with Nāda-brahman’s vibration, or AUM̐’s/16’s cosmic pulsations. In making the mṛdaṅga, the body externalises inner aural potential, and while playing it, fuses the body’s and drum’s constitutive buzzing hum, AUM̐, through their own immanent materialities.
Habitat Type Affects Elevational Patterns in Ground-dwelling Arthropod Communities
Authors: Uhey Derek A , Bowker Matthew A , Haubensak Karen A , Auty David , Vissa Sneha , Hofstetter Richard W 
Published: August 2022

AbstractUnderstanding factors that drive biodiversity distributions is central in ecology and critical to conservation. Elevational gradients are useful for studying the effects of climate on biodiversity but it can be difficult to disentangle climate effects from resource differences among habitat types. Here we compare elevational patterns and influences of environmental variables on ground-dwelling arthropods in open- and forested-habitats. We examine these comparisons in three arthropod functional groups (detritivores, predators, and herbivores) and two taxonomic groups (beetles and arachnids). We sampled twelve sites spanning 1,132 m elevation and four life zones, collecting 4,834 individual ground arthropods identified to 123 taxa. Elevation was a strong predicator for arthropod composition, however, patterns differed among functional and taxonomic groups and individual species between open- and forested-habitats. Beetles, arachnids, and predators decreased with elevation in open habitats but increased in forests showing a significant interaction between habitat type and elevation. Detritivores and herbivores showed no elevational patterns. We found 11 arthropod taxa with linear elevational patterns, seven that peaked in abundance at high elevations, and four taxa at low elevations. We also found eight taxa with parabolic elevational patterns that peaked in abundance at mid-elevations. We found that vegetation composition and productivity had stronger explanatory power for arthropod composition in forested habitats, while ground cover was a stronger predictor in open habitats. Temperature and precipitation were important in both habitats. Our findings demonstrate that relationships between animal diversity and elevation can be mediated by habitat type, suggesting that physiological restraints and resource limitations work differently between habitat types.
Assessment of Caregivers’ Burden When Caring for Patients With Pancreatic and Periampullary Cancer
Authors: Fong Zhi Ven , Teinor Jonathan , Yeo Theresa P , Rinaldi Dee , Greer Jonathan B , Lavu Harish , Qadan Motaz , Johnston Fabian M , Ferrone Cristina R , Chang David C , Yeo Charles J , Wolfgang Christopher L , Warshaw Andrew L , Lillemoe Keith D , Fernandez-del Castillo Carlos , Weiss Matthew J , Wolff Jennifer L , Wu Albert W 
Published: August 2022

Abstract

Background
Family and other unpaid caregivers play an active role in the recovery of individuals with pancreatic and periampullary cancer after pancreatectomy. However, little is known about caregivers’ experiences and how to better support them.

Methods
Caregivers accompanying patients to 1-month postpancreatectomy visits at 3 hospitals completed an electronic survey between November 2018 and February 2020. We examine measures of absenteeism and work productivity loss among the subset of caregivers who reported working for pay and comparatively assess caregiver experiences by employment status. All analyses were performed as 2-sided tests.

Results
Of 265 caregivers approached for study participation, 240 (90.6%) enrolled. Caregivers were primarily female (70.8% female, 29.2% male) and spouses (58.3%) or adult children (25.8%) of patients, with a median age of 60 years. Of the 240 caregivers included in the study, 107 (44.6%) worked for pay. Nearly half (44.4%) of working caregivers reported being absent from work because of caregiving amounting to a 14% loss in work hours. While at work, 58.9% of working caregivers reported increased work difficulty as a result of caregiving. Taken together, an estimated 59.7% loss in work productivity was experienced because of caregiving in the month following pancreatectomy. After adjustment for sociodemographic factors, working (vs nonworking) caregivers reported increased financial (odds ratio [OR] = 2.32; P = .04) and emotional (OR = 1.93; P = .04) difficulties and daily activity restrictions (OR = 1.85; P = .048).

Conclusions
Working caregivers of patients with pancreatic and periampullary cancer experience negative impacts on work and productivity, and caregiving-related financial and emotional difficulties may be amplified. This study highlights the need for workplace policies to support unpaid cancer caregiving.
Immune Microenvironment and Lineage Tracing Help to Decipher Rosette-Forming Glioneuronal Tumors: A Multi-Omics Analysis
Authors: Lerond Julie , Morisse Mony Chenda , Letourneur Quentin , Gimonnet Coralie , Navarro Soledad , Gaspar Cassandra , Idbaih Ahmed , Bielle Franck 
Published: August 2022

Abstract
Rosette-forming glioneuronal tumors (RGNT) are rare low-grade primary central nervous system (CNS) tumors. The methylation class (MC) RGNT (MC-RGNT) delineates RGNT from other neurocytic CNS tumors with similar histological features. We performed a comprehensive molecular analysis including whole-exome sequencing, RNAseq, and methylome on 9 tumors with similar histology, focusing on the immune microenvironment and cell of origin of RGNT. Three RGNT in this cohort were plotted within the MC-RGNT and characterized by FGFR1 mutation plus PIK3CA or NF1 mutations. RNAseq analysis, validated by immunohistochemistry, identified 2 transcriptomic groups with distinct immune microenvironments. The “cold” group was distinguishable by a low immune infiltration and included the 3 MC-RGNT and 1 MC-pilocytic astrocytoma; the “hot” group included other tumors with a rich immune infiltration. Gene set enrichment analysis showed that the “cold” group had upregulated NOTCH pathway and mainly oligodendrocyte precursor cell and neuronal phenotypes, while the “hot” group exhibited predominantly astrocytic and neural stem cell phenotypes. In silico deconvolution identified the cerebellar granule cell lineage as a putative cell of origin of RGNT. Our study identified distinct tumor biology and immune microenvironments as key features relevant to the pathogenesis and management of RGNT.
Change in Seizure Incidence in Febrile Children With COVID-19 in the Era of Omicron Variant of Concern
Authors: Iijima Hiroyuki , Kubota Mitsuru , Ogimi Chikara 
Published: August 2022

Abstract
In this single-center retrospective observational study, we report that the incidence of seizures in febrile children with COVID-19 was significantly higher in the Omicron era than in the pre-Omicron era (14.6% vs 1.7%, P &lt; .001). One-third of the cases in the Omicron era were older than 5 years.
Excitation of vertical breathing motion in disc galaxies by tidally-induced spirals in fly-by interactions
Authors: Kumar Ankit , Ghosh Soumavo , Kataria Sandeep Kumar , Das Mousumi , Debattista Victor P 
Published: August 2022

ABSTRACT
It is now clear that the stars in the Solar neighbourhood display large-scale coherent vertical breathing motions. At the same time, Milky Way-like galaxies experience tidal interactions with satellites/companions during their evolution. While these tidal interactions can excite vertical oscillations, it is still not clear whether vertical breathing motions are excited directly by the tidal encounters or are driven by the tidally-induced spirals. We test whether excitation of breathing motions are directly linked to tidal interactions by constructing a set of N-body models (with mass ratio 5:1) of unbound single fly-by interactions with varying orbital configurations. We first reproduce the well-known result that such fly-by interactions can excite strong transient spirals (lasting for ${\sim}2.9{-}4.2\,{\rm Gyr}$) in the outer disc of the host galaxy. The generation and strength of the spirals are shown to vary with the orbital parameters (the angle of interaction, and the orbital spin vector). Furthermore, we demonstrate that our fly-by models exhibit coherent breathing motions whose amplitude increases with height. The amplitudes of breathing motions show characteristic modulation along the azimuthal direction with compressing breathing motions coinciding with the peaks of the spirals and expanding breathing motions falling in the inter-arm regions – a signature of a spiral-driven breathing motion. These breathing motions in our models end when the strong tidally-induced spiral arms fade away. Thus, it is the tidally-induced spirals which drive the large-scale breathing motions in our fly-by models, and the dynamical role of the tidal interaction in this context is indirect.
Spectroscopic analysis of BPS CS 22940−0009: connecting evolved helium stars
Authors: Snowdon E J , Scott L J A , Jeffery C S , Woolf V M 
Published: August 2022

ABSTRACT
BPS CS 22940−0009 is a helium-rich B-star that shares characteristics with both helium-rich B subdwarfs and extreme helium stars. The optical spectrum of BPS CS 22940−0009 has been analysed from SALT observations. The atmospheric parameters were found to be $T_{\rm eff} = 34\, 970 \pm 370$ K, $\log g/{\rm cm\, s^{-2}} = 4.79 \pm 0.17$, nH/nHe ≃ 0.007, nC/nHe ≃ 0.007, nN/nHe ≃ 0.002, although further improvement to the helium line fits would be desirable. This places the star as a link between the He-sdB and EHe populations in g-T space. The abundance profile shows enrichment of N from CNO-processing, and C from 3α burning. Depletion of Al, Si, S and a low upper limit for Fe show the star to be intrinsically metal-poor. The results are consistent with BPS CS 22940−0009 having formed from the merger of two helium white dwarfs and currently evolving towards the helium main sequence.
On the numerical modelling of astrospheres, including those of luminous blue variable stars, and the modulation of cosmic rays within
Authors: Light Juandré , Ferreira S E S , Engelbrecht N E , Scherer K , Herbst K 
Published: August 2022

ABSTRACT
Luminous blue variable-type stars are massive O-type stars that show variable outflow parameters. These stars can also undergo eruptions where a large amount of mass is ejected in a very short duration. The astrospheres of these stars are modelled using a magnetohydrodynamic model including the effect of radiative cooling. The variation in outflow parameters is demonstrated to lead to a variation in number density up to the termination shock, after which there is no effect in the post-shocked regions. On the other hand, eruptions increase the size of the astrosphere and cause the termination shock to oscillate between the inner boundary and the astropause. Galactic cosmic ray modulation within these types of astrospheres is also studied using a 1D stochastic differential equation model. It is shown that, even though these astrospheres are considerably larger than the heliosphere, calculated cosmic ray differential intensities remain larger than what is observed in the heliosphere at Earth, implying lower levels of modulation related to larger cosmic ray diffusion coefficients. During eruptive events, modelled cosmic ray intensities fluctuate due to the oscillating termination shock, and varying plasma parameters. It is also shown that such behaviour, can in principle, lead to the acceleration of these particles, but the results of this study, due to the 1D approach taken to solving the Parker transport equation, are argued to represent an upper limit to this phenomenon.
OGLE-2019-BLG-1470LABc: Another microlensing giant planet in a binary system?
Authors: Kuang (匡仁昆) Renkun , Zang (臧伟呈) Weicheng , Jung Youn Kil , Udalski Andrzej , Yang (杨弘靖) Hongjing , Mao (毛淑德) Shude , Albrow Michael D , Chung Sun-Ju , Gould Andrew , Han Cheongho , Hwang Kyu-Ha , Ryu Yoon-Hyun , Shin In-Gu , Shvartzvald Yossi , Yee Jennifer C , Cha Sang-Mok , Kim Dong-Jin , Kim Hyoun-Woo , Kim Seung-Lee , Lee Chung-Uk , Lee Dong-Joo , Lee Yongseok , Park Byeong-Gon , Pogge Richard W , Mróz Przemek , Skowron Jan , Poleski Radoslaw , Szymański Michał K , Soszyński Igor , Pietrukowicz Paweł , Kozłowski Szymon , Ulaczyk Krzysztof , Rybicki Krzysztof A , Iwanek Patryk , Wrona Marcin , Gromadzki Mariusz , Wang (王涵悦) Hanyue , Huang (黄硕) Shuo , Zhu (祝伟) Wei 
Published: August 2022

ABSTRACT
We report the discovery and analysis of a candidate triple-lens single-source (3L1S) microlensing event, OGLE-2019-BLG-1470. This event was first classified as a normal binary-lens single-source (2L1S) event, but a careful 2L1S modelling showed that it needs an additional lens or source to fit the observed data. It is found that the 3L1S model provides the best fit, but the binary-lens binary-source (2L2S) model is only disfavoured by Δχ2 ≃ 18. All of the feasible models include a planet with planet-to-host mass-ratios 10−3 ≲ q ≲ 10−2. A Bayesian analysis based on a Galactic model indicates that the planet is super-Jovian, and the projected host-planet separation is about 3 au. Specifically, for the best-fitting 3L1S model, the two stars have masses of $M_1=0.57^{+0.43}_{-0.32}{\rm M}_{\odot}$, and $M_2=0.18^{+0.15}_{-0.10}\mathrm{M}_{\odot}$ with projected separation of $1.3^{+0.5}_{-0.5}$ au, and the planetary mass is $M_3=2.2^{+1.8}_{-1.3}M_{\rm {Jupiter}}$. For the 2L2S model, the masses of the host star and the planet are $0.55^{+0.44}_{-0.31}\mathrm{M}_{\odot }$ and $4.6^{+3.7}_{-2.6}M_{\rm {Jupiter}}$, respectively. By investigating the properties of all known microlensing planets in binary systems, we find that all planets in binary systems published by the KMTNet survey are located inside the resonant caustics range with q ≳ 2 × 10−3, indicating the incompleteness of the KMTNet sample for planets in binary systems. Thus, planets in binary systems cannot be included in the current study of the KMTNet mass-ratio function, and a systematic search for planetary anomalies in KMTNet microlensing light curves of binary systems is needed.