bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different protein intake in the first year and its effects on adiposity rebound and obesity throughout childhood: 11 years follow‐up of a randomized controlled trial
Authors: Totzauer Martina , Escribano Joaquin , Closa‐Monasterolo Ricardo , Luque Veronica , Verduci Elvira , ReDionigi Alice , Langhendries Jean‐Paul , Martin Françoise , Xhonneux Annick , Gruszfeld Dariusz , Socha Piotr , Grote Veit , Koletzko Berthold ,   The European Childhood Obesity Trial Study Group
Published: July 2022

SummaryBackground and ObjectivesInfant feeding affects child growth and later obesity risk. We examined whether protein supply in infancy affects the adiposity rebound, body mass index (BMI) and overweight and obesity up to 11 years of age.MethodsWe enrolled healthy term infants from five European countries in a double blind randomized trial, with anticipated 16 examinations within 11 years follow‐up. Formula‐fed infants (n = 1090) were randomized to isoenergetic formula with higher or lower protein content within the range stipulated by EU legislation in 2001. A breastfed reference group (n = 588) was included. Adiposity rebound and BMI trajectories were estimated by generalized additive mixed models in 917 children, with 712 participating in the 11 year follow‐up.ResultsBMI trajectories were elevated in the higher compared to the lower protein group, with significantly different BMI at adiposity rebound (0.24 kg/m2, 0.01–0.47, p = 0.040), and an increased risk for overweight at 11 years (adjusted Odds Ratio 1.70; 1.06–2.73; p = 0.027) but no significant difference for obesity (adjusted Odds Ratio 1.47; 0.66–3.27). The two formula groups did not differ in the timing of adiposity rebound, but all children with obesity at 11 years had an early adiposity rebound before four years.ConclusionsCompared to conventional high protein formula, feeding lower protein formula in infancy lowers BMI trajectories up to 11 years and achieves similar BMI values at adiposity rebound as observed in breastfed infants.
Methods of coping with neoplastic disease in men with non‐muscle‐invasive bladder cancer
Authors: Mazur Małgorzata , Chorbińska Joanna , Nowak Łukasz , Halska Urszula , Bańkowska Kinga , Sójka Aleksandra , Małkiewicz Bartosz , Zdrojowy Romuald , Pałęga Anna , Szydełko Tomasz , Krajewski Wojciech 
Published: July 2022

AbstractOnly limited data evaluating coping methods in patients with bladder cancer are available in the literature. Also, it is unclear how the mental status of these patients affects their stress coping strategies. The aim of the study was to evaluate the stress coping strategies in patients with non‐muscle‐invasive bladder cancer (NMIBC) and to assess the impact of sociodemographic factors, presence of anxiety and depressive symptoms and degree of sexual satisfaction on stress coping strategies. This prospective cohort study included 100 male patients qualified for control cystoscopy who underwent at least one transurethral resection of bladder tumour (TURB) procedure in the past for NMIBC and at least one control cystoscopy. The minimal follow‐up period after primary TURB was 1 year. The MiniCOPE, the Hospital Anxiety and Depression Scale and the Sexual Satisfaction Questionnaire were used. The questionnaires were completed anonymously before cystoscopy in a room that provided privacy. Majority patients with NMIBC chosen adaptive strategies, with ‘accepting’ and ‘seeking emotional support’ being the most common. The choice of strategy was influenced by the severity of anxiety and depressive symptoms as well as the level of sexual satisfaction and pain sensations. Also, sociodemographic variables, such as marriage status, progeniture or the level of education played a role in strategy selection. The results of this study indicate that patients with NMIBC choose adaptive stress coping strategies. It also provides a better understanding of the impact of various aspects of mental health in patients with NMIBC on coping with stress. Each patient treated for NMIBC should undergo appropriate psychological and sociodemographic evaluation, which will allow easier identification of patients at high risk of treatment and postoperative surveillance discontinuation.
Identification of necroptosis‐related gene signature and characterization of tumour microenvironment infiltration in non‐small‐cell lung cancer
Authors: Dai Juji , Fu Yangyang 
Published: July 2022

AbstractNecroptosis is a programmed necrosis in a caspase‐independent fashion. The role of necroptosis‐related genes (NRGs) in lung cancer remains unknow. Herein, we classified TCGA‐LUAD cohort into two necroptosis‐related subtypes (C1 and C2) by consensus clustering analysis. The result showed that subtype C1 had a favourable prognosis and higher infiltration levels of immune cells. Moreover, subtype C1 was more activated in immune‐associated pathways. Then, we established an NRG prognosis model (NRG score) composed of six NRGs (RIPK3, MLKL, TLR2, TLR4, TNFRSF1A, NDRG2) and divided the cohort into low‐ and high‐risk group. We found that the NRG score was associated with prognosis, tumour immune microenvironment and tumour mutation burden. We also constructed an accurate nomogram model to improve the clinical applicability of NRG score. The result indicated that NRG score may be an independent prognostic marker for lung cancer patients. Taken together, we established a prognosis model that may deepen the understanding of NRGs in lung cancer and provide a basis for developing more effective immunotherapy strategies.
Functional analysis of mutant SLCO2A1 transporters found in patients with chronic enteropathy associated with SLCO2A1
Authors: Seki Satowa , Tanaka Gen , Kimura Toru , Hayashida Mari , Miyoshi Jun , Matsuura Minoru , Sakurai Hiroyuki , Hisamatsu Tadakazu 
Published: July 2022

AbstractBackground and AimChronic enteropathy associated with the solute carrier organic anion transporter family member 2A1 (SLCO2A1), or CEAS, causes anemia and hypoalbuminemia in young people. Dysfunction of the SLCO2A1 transporter protein is thought to involve genetic mutation, but mutant proteins have not been functionally characterized. We examined the prostaglandin E2 (PGE2) transport ability of recombinant SLCO2A1 proteins containing 11 SLCO2A1 mutations found in CEAS patients.MethodsWild‐type and mutant SLCO2A1 proteins were forcibly expressed in Xenopus laevis oocytes, and measurements of PGE2 uptake and transport capacity were compared. The membrane protein topology and functionality of the eight SLCO2A1 mutations involving single‐nucleotide substitutions were predicted using computer analysis.ResultsThe extent of functional disruption of the 11 SLCO2A1 mutations identified in CEAS patients was variable, with 10 mutations (421GT, 547GA, 664GA, 770GA, 830dupT, 830delT, 940 + 1GA, 1372GT, 1647GT, and 1807CT) resulting in loss or reduction of PGE2 transport, excluding 97GC.ConclusionPGE2 transport ability of recombinant SLCO2A1 in X. laevis oocytes was hindered in 10/11 SLCO2A1 mutations identified in patients with CEAS. Further studies on the relationships between the different mutations and PGE2 transport and clinical features, such as severity, are needed.
Women's Health Care Committee, Japan Society of Obstetrics and Gynecology: Annual report—2022
Authors: Terauchi Masakazu , Higuchi Tsuyoshi 
Published: July 2022

AbstractThe Women's Health Care Committee was instituted in 2010 with the goal of improving women's health. In the current academic year, there are 6 subcommittees focusing on conducting the following surveys: (1) Current status of pregnancy‐associated breast cancer in Japan; (2) Surgery for disorders of sex development; (3) Diagnosis and treatment of premenstrual syndrome and premenstrual dysphoric disorder; (4) Obstetrics and gynecology‐based treatment for patients with eating disorders in Japan; (5) Multi‐drug‐resistant bacterial infections in the field of obstetrics and gynecology; and (6) Changing methodology of treatment of dysmenorrhea and continuing medical education. The activities of each subcommittee are detailed below. This report is based on the Japanese version of the annual report (Acta Obst Gynaec Jpn 2022;74(6): XXX–XXX).
Building School Connectedness Through Structured Recreation During School: A Concurrent Mixed‐Methods Study
Authors: Wilson Kylie , Ramella Kelly , Poulos Allison 
Published: July 2022

ABSTRACTBACKGROUNDSchool connectedness (SC) is associated with improved health and academic outcomes. The purposes of this study were to explore factors contributing to students' perceptions of SC and if participation in structured recreation at school was associated with SC.METHODSWe used concurrent mixed‐methods including cross‐sectional qualitative data to explore factors contributing to SC among fifth‐ and sixth‐grade students at 2 schools in Phoenix, AZ, USA (N = 330), and quantitative measures to explore the association between SC and recreation participation (N = 129). Students completed a journaling activity to identify factors contributing to feelings of SC. Responses were analyzed using both deductive and inductive approaches. Student surveys were analyzed using 1‐way analyses of variance to assess differences between participation level and SC.RESULTSEight themes contributing to SC emerged: Relationships (peer, adult), Competence (competence), Autonomy (choice), Relax (relax), Recreation (structured, play), Fun (fun), Academics (academic learning), and Environment (food and safety). Participation in structured recreation programming in the classroom and at recess were associated with higher levels of SC (p < .05).CONCLUSIONSSchool practitioners can integrate opportunities for structured recreation in the classroom and at recess as a fun and engaging strategy to foster adult support and peer relationships, enhancing SC.
Health Literacy and COVID‐19 Awareness Among Preservice Primary School Teachers and Influencing Factors in Turkey
Authors: Öztürk Fatma Özlem , Tezel Ayfer 
Published: July 2022

AbstractBackgroundPrimary school teachers play an important role in furnishing children with basic knowledge about health literacy and awareness of COVID‐19. This study was conducted to determine the levels of health literacy and COVID‐19 awareness among preservice primary school teachers and the factors associated with this.MethodsThe sample of this cross‐sectional and correlational study consists of 978 preservice primary school teachers studying at 4 major universities in Turkey. The participation rate was 90.14%. Data were collected with 3 questionnaires, the Descriptive Characteristics Form, the Health Literacy Scale, and the COVID‐19 Awareness Scale.ResultsThe mean score of the Health Literacy scale was 105.16 (SD = 13.04). The mean scores of the Contagion Precaution Awareness, Awareness of Following Current Developments, and Hygiene Precaution Awareness subscales of the Coronavirus Awareness Scale were 34.27 (SD = 6.19), 12.94 (SD = 4.34), and 11.69 (SD = 3.60), respectively. It was determined that the total health literacy score was affected by gender, school, and grade/year (freshman, sophomore, junior, senior) and that COVID‐19 awareness was affected by gender, age, grade/year, school, having contracted COVID‐19 or not, and being vaccinated or not in the various subscales (p < 0.05).ConclusionsPreservice primary school teachers' health literacy was found to be sufficient with a moderate level of COVID‐19 awareness. We recommend planning interventions for preservice primary school teachers that will improve their health literacy and COVID‐19 awareness, taking influential factors into account when doing this planning.
Role of hepatitis B surface antibody in seroreversion of hepatitis B surface antigen in patients achieving hepatitis B surface antigen loss with pegylated interferon‐based therapy
Authors: Gao Na , Yu Huiying , Zhang Jing , Mo Zhishuo , Chu Junhao , Xie Chan , Peng Liang , Gao Zhiliang 
Published: July 2022

AbstractIt is unclear whether hepatitis B surface antibody (HBsAb) confers clinical benefits after HBsAg seroclearance, especially in hepatitis B surface antigen (HBsAg) seroreversion and maintenance of HBsAb. We evaluated this in patients (n = 222) with HBsAg loss following treatment with pegylated interferon (PEG‐IFN)‐based therapy who completed a 48‐week follow‐up period. Serum hepatitis B virus (HBV) markers and biochemical indicators were evaluated every 3 months. The primary endpoint was HBsAg seroreversion. Factors associated with HBsAg seroreversion were also investigated. HBsAb ≥100 mIU/ml resulted in a lower HBsAg seroreversion rate than an HBsAb‐negative status (5.5% vs. 29.5%, p < .001); however, the seroreversion rate was not significantly different between patients with HBsAb 10–100 mIU/ml and those in the HBsAb‐negative group. Patients with HBsAb ≥100 mIU/ml had a lower HBsAb loss rate than those with HBsAb 10–100 mIU/ml (7.3% vs. 21.7%, p = .005). The final HBsAg seroreversion and HBV DNA relapse rates were 13.5% and 1.8%, respectively. HBsAb ≥100 mIU/ml at the off‐treatment time (odds ratio [OR] 0.110, 95% confidence interval [CI]: 0.034–0.353, p < .001) and treatment time to attain HBsAg loss >28 weeks (OR 2.508, 95% CI: 1.068–5.890, p = .035) were predictors of HBsAg seroreversion. Consolidation therapy for 12–24 weeks resulted in higher HBsAb titres than consolidation therapy for ≤12 weeks in HBsAb‐negative patients at the off‐treatment time (p < .001). HBsAg seroconversion with HBsAb ≥100 mIU/ml decreases HBsAg seroreversion and provides an efficient maintenance rate of HBsAb. HBsAg seroconversion with high HBsAb titres may be clinically beneficial for chronic hepatitis B treated with PEG‐IFN‐based therapy.
Nurses' experience of an Extracorporeal Membrane Oxygentation (ECMO) clinical support team during the COVID‐19 pandemic: A service evaluation
Authors: Shaffi Danielle , Driver Kimberley , Shaw Núñez Emma 
Published: July 2022

AbstractBackgroundThe COVID‐19 pandemic placed unprecedented stress on the National Health Service and critical care units including those with Extracorporeal Membrane Oxygenation (ECMO) facility as this intervention had proved successful with H1N1 patients in 2009. To successfully care for the influx of ECMO patients, an ECMO clinical support team (ECST) formed by redeployed staff was created to assist critical care nurses.AimThis service evaluation aims to review the experience of critical care nursing staff working with an ECST during the period of increased provision of ECMO care.Study DesignA UK‐based single‐site qualitative service evaluation was followed.MethodCritical care nursing staff's feedback was anonymously collected using a paper questionnaire designed for this project. Data were analysed using inductive content analysis.FindingsApproximately 40 critical care nurses were invited to complete a questionnaire, 19 (48%) of whom completed it within the available timeframe. A variety of themes were identified including ‘Prior knowledge of ECST’, ‘Management matters’, ‘ECST in action’, ‘ECST response’, ‘Emotions’ and ‘Overall experience of the ECST’. Staff initially reported apprehension regarding a new team and training responsibilities. Following the rollout of the ECST, nurses' accounts described the utilization of the ECST and subsequent stress relief. Feedback commented on the ECST's positive attitude, effective team working with the critical care team and provision of moral support. Nurses' gratitude was strongly conveyed throughout, with many expressing the positive effect of the ECST on staff emotional well‐being.ConclusionThe implementation of the ECST provided clinical and emotional support to nurses. The ECST demonstrated the effective use of redeployed health care staff to support the critical care unit at a time of a significant increase in patients requiring ECMO. This could be used as a model to enhance staffing levels in the event of future viral outbreaks.
The nature of the Late Syn‐rift Sag Basin (LSSB)
Authors: Wu Lulu , Shen Chuanbo , Paton Douglas A. , Hou Yanping , Mei Lianfu , Zeng Xiaowei , Shi Guanzhong 
Published: July 2022

AbstractThe “steer's head” geometry and saucer‐shaped architecture in rift basins are generally regarded as a direct consequence of thermal subsidence and post‐rift evolution. However, these definitions can be problematic due to the widespread coexistence of synchronous wedge‐shaped and saucer‐shaped geometries in many rift basins and rifted margins globally. Although the Late Syn‐rift Sag Basins (LSSBs) at rifted margins provide an alternative model for the discrepancy, their nature remains enigmatic. Using high‐resolution 3D seismic data in the Hailar Rift, for the first time, our study deciphers the 3D architecture and strain behaviour of the LSSB. We identify four types of architectures which suggest that the strain behaviour within the LSSB is dominated by sagging, with varying degree of the mixing of faulting and sagging. The LSSB is considered to be the shallow response to the ductile deformation of lower crust, accompanied by the increase in heat flow.
The sloppy relationship between neural circuit structure and function
Authors: Hennig Matthias H. 
Published: July 2022

AbstractInvestigating and describing the relationships between the structure of a circuit and its function has a long tradition in neuroscience. Since neural circuits acquire their structure through sophisticated developmental programmes, and memories and experiences are maintained through synaptic modification, it is to be expected that structure is closely linked to function. Recent findings challenge this hypothesis from three different angles: function does not strongly constrain circuit parameters, many parameters in neural circuits are irrelevant and contribute little to function, and circuit parameters are unstable and subject to constant random drift. At the same time, however, recent work also showed that dynamics in neural circuit activity that is related to function are robust over time and across individuals. Here this apparent contradiction is addressed by considering the properties of neural manifolds that restrict circuit activity to functionally relevant subspaces, and it will be suggested that degenerate, anisotropic and unstable parameter spaces are closely related to the structure and implementation of functionally relevant neural manifolds.
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Inflammatory gene expression during acute high‐altitude exposure
Authors: Pham Kathy , Frost Shyleen , Parikh Keval , Puvvula Nikhil , Oeung Britney , Heinrich Erica C. 
Published: July 2022

AbstractThe molecular signalling pathways that regulate inflammation and the response to hypoxia share significant crosstalk and appear to play major roles in high‐altitude acclimatization and adaptation. Several studies demonstrate increases in circulating candidate inflammatory markers during acute high‐altitude exposure, but significant gaps remain in our understanding of how inflammation and immune function change at high altitude and whether these responses contribute to high‐altitude pathologies, such as acute mountain sickness. To address this, we took an unbiased transcriptomic approach, including RNA sequencing and direct digital mRNA detection with NanoString, to identify changes in the inflammatory profile of peripheral blood throughout 3 days of high‐altitude acclimatization in healthy sea‐level residents (n = 15; five women). Several inflammation‐related genes were upregulated on the first day of high‐altitude exposure, including a large increase in HMGB1 (high mobility group box 1), a damage‐associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Differentially expressed genes on the first and third days of acclimatization were enriched for several inflammatory pathways, including nuclear factor‐κB and Toll‐like receptor (TLR) signalling. Indeed, both TLR4 and LY96, which encodes the lipopolysaccharide binding protein (MD‐2), were upregulated at high altitude. Finally, FASLG and SMAD7 were associated with acute mountain sickness scores and peripheral oxygen saturation levels on the first day at high altitude, suggesting a potential role of immune regulation in response to high‐altitude hypoxia. These results indicate that acute high‐altitude exposure upregulates inflammatory signalling pathways and might sensitize the TLR4 signalling pathway to subsequent inflammatory stimuli.
imageKey points
Inflammation plays a crucial role in the physiological response to hypoxia.
High‐altitude hypoxia exposure causes alterations in the inflammatory profile that might play an adaptive or maladaptive role in acclimatization.
In this study, we characterized changes in the inflammatory profile following acute high‐altitude exposure.
We report upregulation of novel inflammation‐related genes in the first 3 days of high‐altitude exposure, which might play a role in immune system sensitization.
These results provide insight into how hypoxia‐induced inflammation might contribute to high‐altitude pathologies and exacerbate inflammatory responses in critical illnesses associated with hypoxaemia.
La incidencia en políticas educativas de las ONG ¿necesidad o sentido? : el caso de Fe y Alegría y Fundación Escuela Nueva en Colombia
Authors:   , Sánchez Valdez Gonzalo Jorge 
Published: July 2022

Esta investigación inicia explicando la crisis actual de hegemonía en la relación del Estado y la sociedad civil. Se explica también que la educación en la actualidad tiene un "déficit de sentido". En ese marco, se exploran las razones históricas y presentes que tienen las ONG para hacer incidencia en políticas educativas, y se establecen algunas condiciones que se deben cumplir para lograr esta incidencia.
Demanda de la consulta médica preventiva en Colombia : determinantes y evidencia de inducción por oferta
Authors:   , Guerrero Victoria José Julián 
Published: July 2022

El objetivo de esta investigación esdeterminar, para el caso de Colombia en 2012 (empleando la Encuesta Nacional de Calidad de Vida del DANE), cómo factores individuales, socioeconómicos y de inducción por oferta tienen efectos estadísticamente significativos (positivos o negativos) sobre la probabilidad de ocurrencia del evento "asistir a consulta médica sin estar enfermo" medida de demanda por servicio médico preventivo-. Siguiendo la metodología de Kenkel (1990, 1994), se estimaron modelos logit. Los resultados son congruentes con las intuiciones y desarrollos teóricos y antecedentes empíricos. Sin embargo, se destaca que pertenecer tanto al régimen subsidiado como al contributivo (privado y mejor) reduce la demanda medica preventiva, mientras que haberse quejado del servicio médico la aumenta, además, se encuentra que las campañas de promoción y prevención de salud que realizan las secretarías de salud no tienen ningún efecto.
Modelo de pago por desempeño para médicos generales en una institución ambulatoria prestadora de servicios de salud en Bogotá
Authors:   , Bastidas Rosas Julieta María , Gutiérrez Álvarez Aida Milena 
Published: July 2022

La propuesta tiene su origen en la necesidad de garantizar un mejoramiento continuo de la Fundación Javeriana de Servicios Médicos Odontológicos Interuniversitarios "Carlos Márquez Villegas" Javesalud, lo cual redundará en una excelente calidad y continuidad en la atención, en mantener una ejecución- costo efectiva de la operación, reducir la rotación del personal médico y obtener un mayor número de resultados clínicos satisfactorios que permitan cumplir metas clínicas de control, promoción y prevención. Se realizó una revisión de la literatura en búsqueda de modelos P4P diseñados para motivar a los profesionales de las instituciones para lograr mejores resultados clínicos y en la calidad de la atención. Se realizó una encuesta a los proveedores Javesalud para determinar sus características sociodemográficas y sus preferencias a partir de las cuales se diseñó un modelo P4P para los médicos generales en Javesalud.