bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep disturbances in ADHD: investigating the contribution of polygenic liability for ADHD and sleep-related phenotypes
Authors: Lewis Katie J. S. , Martin Joanna , Gregory Alice M. , Anney Richard , Thapar Anita , Langley Kate 
Published: January 2022

AbstractSleep disturbances are common in attention deficit hyperactivity disorder (ADHD) and associated with poor outcomes. We tested whether, in children with ADHD, (1) polygenic liability for sleep phenotypes is over- or under-transmitted from parents, (2) this liability is linked to comorbid sleep disturbances, and (3) ADHD genetic risk is associated with comorbid sleep disturbances. We derived polygenic scores (PGS) for insomnia, chronotype, sleep duration, and ADHD, in 758 children (5–18 years old) diagnosed with ADHD and their parents. We conducted polygenic transmission disequilibrium tests for each sleep PGS in complete parent–offspring ADHD trios (N = 328) and an independent replication sample of ADHD trios (N = 844). Next, we tested whether insomnia, sleep duration, and ADHD PGS were associated with co-occurring sleep phenotypes (hypersomnia, insomnia, restless sleep, poor sleep quality, and nightmares) in children with ADHD. Children’s insomnia and chronotype PGS did not differ from mid-parent average PGS but long sleep duration PGS were significantly over-transmitted to children with ADHD. This was supported by a combined analysis using the replication sample. Insomnia, sleep duration, and ADHD PGS were not associated with comorbid sleep disturbances. There is weak evidence that children with ADHD over-inherit polygenic liability for longer sleep duration and do not differentially inherit polygenic liability for insomnia or chronotype. There was insufficient evidence that childhood sleep disturbances were driven by polygenic liability for ADHD or sleep traits, suggesting that sleep disturbances in ADHD may be aetiologically different to general population sleep phenotypes and do not index greater ADHD genetic risk burden.
A computational status update for exact rational mixed integer programming
Authors: Eifler Leon , Gleixner Ambros 
Published: January 2022

AbstractThe last milestone achievement for the roundoff-error-free solution of general mixed integer programs over the rational numbers was a hybrid-precision branch-and-bound algorithm published by Cook, Koch, Steffy, and Wolter in 2013. We describe a substantial revision and extension of this framework that integrates symbolic presolving, features an exact repair step for solutions from primal heuristics, employs a faster rational LP solver based on LP iterative refinement, and is able to produce independently verifiable certificates of optimality. We study the significantly improved performance and give insights into the computational behavior of the new algorithmic components. On the MIPLIB 2017 benchmark set, we observe an average speedup of 10.7x over the original framework and 2.9 times as many instances solved within a time limit of two hours.
How Does Fluid Flow Influence Drug Release from Drug Filled Implants?
Authors: King David , McCormick Christopher , McGinty Sean 
Published: January 2022

AbstractDrug-filled implants (DFIs) have emerged as an innovative approach to control the delivery of drugs. These devices contain the drug within the structure of the implant itself and avoid the need to include additional drug carrier materials such as a polymers, which are often associated with inflammation and delayed healing/tissue regeneration at the implant site. One common feature of in vitro experiments to generate drug release profiles is stirring or agitation of the release medium. However, the influence of the resulting fluid flow on the rate of drug release from DFIs has yet to be quantified. In this paper we consider two DFIs, which although similar in shape and size, employ different strategies to control the release of drug: a porous pin with pores on the order of μm and a pin drilled with orifices of the order of mm. We develop a multiphysics mathematical model of drug release from these DFIs, subject to fluid flow induced through stirring and show that fluid flow greatly influences the drug release profile for the orifice pin, but that the porous pin drug release profile is relatively insensitive to flow. We demonstrate that drug release from the porous pin may adequately be described through a simplified radial 1D dissolution-diffusion model, while a 3D dissolution-advection-diffusion model is required to describe drug release from the orifice pin. A sensitivity analysis reveals that that the balance of reaction-advection-diffusion in terms of key nondimensional numbers governs the overall drug release. Our findings potentially have important implications in terms of devising the most relevant experimental protocol for quantifying drug release from DFIs.
Racism and Older Black Americans’ Health: a Systematic Review
Authors: LaFave S. E. , Suen J. J. , Seau Q. , Bergman A. , Fisher M. C. , Thorpe R. J. , Szanton S. L. 
Published: January 2022

AbstractWe reviewed research that examines racism as an independent variable and one or more health outcomes as dependent variables in Black American adults aged 50 years and older in the USA. Of the 43 studies we reviewed, most measured perceived interpersonal racism, perceived institutional racism, or residential segregation. The only two measures of structural racism were birth and residence in a “Jim Crow state.” Fourteen studies found associations between racism and mental health outcomes, five with cardiovascular outcomes, seven with cognition, two with physical function, two with telomere length, and five with general health/other health outcomes. Ten studies found no significant associations in older Black adults. All but six of the studies were cross-sectional. Research to understand the extent of structural and multilevel racism as a social determinant of health and the impact on older adults specifically is needed. Improved measurement tools could help address this gap in science.
Modeling and Simulation of Pore Formation in a Bainitic Steel During Creep
Authors: Meixner Felix , Ahmadi Mohammad Reza , Sommitsch Christof 
Published: January 2022

Abstract
In the field of power engineering, where materials are subjected to high pressures at elevated temperatures for many decades, creep-resistant steels are put to work. Their service life is still, however, finite, as the many changes in their microstructure can merely be mitigated and not avoided. Creep cavitation is one of those changes and, in many cases, ultimately causes failure by rupture. In this work, a model is proposed to simulate the nucleation and growth of cavities during creep. This exclusively physics-based model uses modified forms of Classical Nucleation Theory and the Onsager Extremum Principle in a newly developed Kampmann–Wagner framework. The model is validated on P23 steel which underwent creep rupture experiments at 600 °C and stresses of 50, 70, 80, 90 and 100 MPa for creep times up to 46000 hours. The model predicts qualitatively the shape and prevalence of cavities at different sites in the microstructure, and quantitatively the number density, size of cavities and their phase fraction contributing to a reduction in density. Finally, we find good agreement between the simulation and the experimental results especially at low stresses and longer creep times.
TREX1 Deficiency Induces ER Stress-Mediated Neuronal Cell Death by Disrupting Ca2+ Homeostasis
Authors: Halder Debasish , Jeon Su-Jin , Yoon Ji-Yong , Lee Jeong-Ju , Jun Soo Young , Choi Min-Hyuk , Jeong Bohyeon , Sung Duk Hyun , Lee Da Yong , Kim Byoung Joon , Kim Nam-Soon 
Published: January 2022

AbstractTREX1 is an exonuclease that degrades extranuclear DNA species in mammalian cells. Herein, we show a novel mechanism by which TREX1 interacts with the BiP/GRP78 and TREX1 deficiency triggers ER stress through the accumulation of single-stranded DNA and activates unfolded protein response (UPR) signaling via the disruption of the TREX1-BiP/GRP78 interaction. In TREX1 knockdown cells, the activation of ER stress signaling disrupted ER Ca2+ homeostasis via the ERO1α-IP3R1-CaMKII pathway, leading to neuronal cell death. Moreover, TREX1 knockdown dysregulated the Golgi-microtubule network through Golgi fragmentation and decreased Ac-α-tubulin levels, contributing to neuronal injury. These alterations were also observed in neuronal cells harboring a TREX1 mutation (V91M) that has been identified in hereditary spastic paraplegia (HSP) patients in Korea. Notably, this mutation leads to defects in the TREX1-BiP/GRP78 interaction and mislocalization of TREX1 from the ER and possible disruption of the Golgi-microtubule network. In summary, the current study reveals TREX1 as a novel regulator of the BiP/GRP78 interaction and shows that TREX1 deficiency promotes ER stress-mediated neuronal cell death, which indicates that TREX1 may hold promise as a therapeutic target for neurodegenerative diseases such as HSP.
Emergency online school learning during COVID-19 lockdown: A qualitative study of adolescents’ experiences in Italy
Authors: Tzankova Iana , Compare Christian , Marzana Daniela , Guarino Antonella , Di Napoli Immacolata , Rochira Alessia , Calandri Emanuela , Barbieri Irene , Procentese Fortuna , Gatti Flora , Marta Elena , Fedi Angela , Aresi Giovanni , Albanesi Cinzia 
Published: January 2022

AbstractThe COVID-19 pandemic caused abrupt and profound changes to teaching and learning. The present study seeks to understand adolescents’ experiences of the emergency adoption of online school learning (OSL) during the first national lockdown in Italy. Sixty-four students in their final two years of high school were interviewed and content analysis was performed. The findings describe students’ views of the changes related to OSL according to structural, individual and relational dimensions. Schools’ lack of organization, overwhelming demands, as well as experience of difficulties in concentration, stress and inhibited relationships with teachers and classmates were among the challenges evidenced in the transition. OSL, however, has also made it possible to experience a new flexibility and autonomy in the organization of learning. The study stresses the importance of fostering adaptation of teacher-student relationships and collaborative learning in order to improve schools’ preparedness for digital transitions in and out of emergencies.
Psychological Well-Being and Social Competence During Adolescence: Longitudinal Association Between the Two Phenomena
Authors: Gómez-López Mercedes , Viejo Carmen , Romera Eva M. , Ortega-Ruiz Rosario 
Published: January 2022

AbstractDespite previous research on adolescence points to an association between social competence and well-being, limited knowledge is available. Most studies have documented a one-way pattern of influence, although reciprocity has also been suggested. However, they mainly use a cross-sectional design, do not focus on psychological well-being, and do not use integrative and multidimensional constructs. From a eudaimonic approach to well-being and situation-specific to social competence, this study aimed to: (1) explore the factorial structure of the dimensions assessed; (2) analyse the longitudinal relationship between psychological well being and social competence during adolescence; and (3) examine psychological well-being and social competence levels and their stability over time. The sample consisted of 662 adolescents aged between 14 and 16 years old (Time 1 Mage = 14.63; SD = 0.64; 51% girls). Structural equation analysis confirmed the existence of second-order factors, showing evidence of a positive and bidirectional relationship between psychological well-being and social competence. Results also revealed medium–high levels in both constructs, which remained stable over time. These findings highlight the importance of promoting both psychological well-being and social competence to achieve successful, healthy development.
The geometric reason for the non-existence of a MOL(6)
Authors: Betten Dieter 
Published: January 2022

AbstractThe problem of Euler concerning the 36 officers, (Euler, in Leonardi Euleri Opera Ser I 7:291–392, 1782), was first solved by Tarry (Comptes rendus Ass Franc Sci Nat 1 (1900) 2:170–203, 1901). Short proofs for the non-existence were given in Betten (Unterricht 36:449–453, 1983), Beth et al. (Design Theory, Bibl. Inst. Mannheim, Wien, Zürich, 1985), Stinson (J Comb Theory A 36:373–376, 1984). This problem is equivalent to the existence of a MOL(6), i. e., a pair of mutually orthogonal latin squares of order 6. Therefore in Betten (Mitt Math Ges Hamburg 39:59–76, 2019; Res Math 76:9, 2021; Algebra Geom 62:815–821, 2021) the structure of a (hypothetical) MOL(6) was studied. Now we combine the old proofs and the new studies and filter out a simple way for the proof of non-existence. The aim is not only to give still other short proofs, but to analyse the problem and reveal the geometric reason for the non-existence of a MOL(6)- and the non-solvability of Euler’s problem.
When It Strikes, Are We Ready? Lessons Identified at the 7th Planetary Defense Conference in Preparing for a Near-Earth Object Impact Scenario
Authors: Ravan Shirish , De Groeve Tom , Mani Lara , Bjorgo Einar , Moissl Richard , Roncero Jose Miguel , Rowan Katherine , Schuld David , Lewis Leviticus A. , Kofler Romana 
Published: January 2022

Abstract
Near-Earth object (NEO) impact is one of the examples of high impact and low probability (HILP) event, same as the Covid-19 pandemic the world faces since the beginning of 2020. The 7th Planetary Defense Conference held by the International Academy of Astronautics (IAA) in April 2021 included an exercise on a hypothetical NEO impact event, allowing the planetary defense community to discuss potential responses. Over the span of the 4-day conference this exercise connected disaster response and management professionals to participate in a series of panels, providing feedback and perspective on the unfolding crisis scenario. The hypothetical but realistic asteroid threat scenario illustrated how such a short-warning threat might evolve. The scenario utilized during the conference indicates a need to prepare now for what might come in the future, because even with advance notice, preparation time might be minimal. This scenario chose Europe for the impact, which may likely cope with such a disaster, through the Union Civil Protection Mechanism (UCPM) and other solidarity and support mechanisms within the European Union (EU), as well as with potential support from international partners. This short article raises concern about other areas in the world on how they may access NEO impact information and cope with such disasters. It also provides an idea on vast scale of such disaster vis-à-vis the current capacity of response systems to cope with a larger event in Europe or elsewhere. This scenario showed that planetary defense is a global endeavor. Constant engagement of the planetary defense and disaster response communities is essential in order to keep the world safe from potential disasters caused by NEO impacts.
Cochlear Implantation in Advanced Otosclerosis: Pitfalls and Successes
Authors: Claussen Alexander D. , Gantz Bruce J. 
Published: January 2022

AbstractPurpose of ReviewThis review will highlight recent outcome-based evidence guiding decision making for cochlear implantation in advanced otosclerosis, related complications, and technical surgical considerations in otosclerosis and the obstructed cochlea.Recent FindingsCochlear implantation in advanced otosclerosis results in consistent, excellent auditory outcomes with improvement in both objective speech recognition scores and subjective quality of life measures. Facial nerve stimulation may occur at higher rates in otosclerosis cochlear implant recipients. Cochlear implantation in the setting of luminal obstruction in osteosclerotic patients may be managed with altered surgical technique to achieve successful auditory improvements. Pre-operative imaging with high resolution CT or MRI may help anticipate intraoperative challenges and post-operative complications in cochlear implantation.SummaryCochlear implantation is an established, successful treatment for profound hearing loss in advanced otosclerosis. Surgeon knowledge of outcomes, complications, and potential surgical challenges is important to appropriately counsel patients regarding auditory rehabilitation options in advanced otosclerosis.
Modulation of spin dynamics in Ni/Pb(Mg1/3Nb2/3)O3-PbTiO3 multiferroic heterostructure
Authors: Xu Hang , Wang Bo , Qi Ji , Liu Mei , Teng Fei , Hu Linglong , Zhang Yuan , Qu Chaoqun , Feng Ming 
Published: January 2022

AbstractMotivated by the fast-developing spin dynamics in ferromagnetic/piezoelectric structures, this study attempts to manipulate magnons (spin-wave excitations) by the converse magnetoelectric (ME) coupling. Herein, electric field (E-field) tuning magnetism, especially the surface spin wave, is accomplished in Ni/0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 (PMN-PT) multiferroic heterostructures. The Kerr signal (directly proportional to magnetization) changes of Ni film are observed when direct current (DC) or alternative current (AC) voltage is applied to PMN-PT substrate, where the signal can be modulated breezily even without extra magnetic field (H-field) in AC-mode measurement. Deserved to be mentioned, a surface spin wave switch of “1” (i.e., “on”) and “0” (i.e., “off”) has been created at room temperature upon applying an E-field. In addition, the magnetic anisotropy of heterostructures has been investigated by E-field-induced ferromagnetic resonance (FMR) shift, and a large 490 Oe shift of FMR is determined at the angle of 45° between H-field and heterostructure plane.
The antioxidative potential of sea grapes (Caulerpa lentillifera, Chlorophyta) can be triggered by light to reach comparable values of pomegranate and other highly nutritious fruits
Authors: Sommer Jonas , Kunzmann Andreas , Stuthmann Lara E. , Springer Karin 
Published: January 2022

AbstractThe interest in edible sea grapes (Caulerpa lentillifera) is increasing due to their potentially beneficial effect on human health. This macroalga, already used for direct and indirect human consumption, is grown in aquacultures in Vietnam and The Philippines. Here, the edible fronds of sea grapes were examined for their antioxidant activity (AOA) at light intensities from 140 to 300 µmol photons m−2 s−1 and compared to commercially dehydrated C. lentillifera and the renowned highly antioxidative fruits Pomegranates (Punica granatum), Goji (Lycium barbarum and L. chinense) and Aronia (Aronia melanocarpa) berries, using an ABTS+-assay for all samples. AOA of fronds exposed to 300 µmol photons m−2 s−1 for 14 days increased by about 320% from the initial value of 72.2 ± 5.6 to 232.2 ± 34.2 Trolox Equivalents (TE) mmol 100 g−1 dry weight (DW) onto the level of Pomegranates (272.8 ± 23.0 TE mmol 100 g−1 DW). This application could be used as a post-cultivation treatment in sea grape cultures to increase the quality and nutritional value of the product.
Sind schwache Leistung und auffälliges Verhalten immer ein Risiko für gelingende Partizipation? Zur Rolle von Kontext und Klassenkohäsion
Authors: Schürer Sina , van Ophuysen Stefanie , Marticke Sophie 
Published: January 2022

ZusammenfassungPartizipation – speziell hohe Akzeptanz/geringe Ablehnung – aller Kinder ist Ziel inklusiver Bildung. Schwache Schulleistungen und Verhaltensprobleme stellen dabei einen Risikofaktor dar, allerdings mit deutlichen Unterschieden zwischen Schulklassen. Inwiefern können diese Unterschiede durch Klassenkohäsion erklärt werden? Gibt es differenzielle Zusammenhänge je nach Partizipationssituation sowie Art des Unterstützungsbedarfs? Für Daten einer standardisierten Befragung von 995 Grundschulkindern aus 45 Klassen wurden hierarchische Regressionsmodelle angepasst. Verhaltensauffälligkeiten und Lernschwierigkeiten sind prädiktiv für geringe Akzeptanz, nur ersteres geht auch mit hoher Ablehnung einher. Kohäsion erhöht Partizipation insgesamt, reduziert jedoch nicht den Nachteil für lernschwache oder verhaltensauffällige Kinder.
Retroperitoneal Mass: Lymphoma as Differential Diagnosis to Retroperitoneal Fibrosis: Case Report
Authors: Nussberger Madalina , Kim Olaf Chan-Hi , Cogliatti Sergio , Müllhaupt Gautier , Neumann Thomas 
Published: January 2022

AbstractThe etiology of solid retroperitoneal mass may be autoimmune or neoplastic and should be investigated by imaging and histology. The spectrum of differential diagnoses includes retroperitoneal fibrosis and retroperitoneal tumors. As treatment for these entities differs substantially, early and accurate diagnosis is essential. We present a case of a 54-year-old woman admitted to our hospital with stroke-like symptoms. Suspecting vasculitis, magnetic resonance imaging of the head and abdomen was performed, which revealed circular enhancement of the internal carotid artery as well as retroperitoneal and periaortic masses. In light of the radiographic findings, an autoimmune process, such as retroperitoneal fibrosis, was hypothesized. Steroid treatment was initiated but did not lead to significant remission. Re-evaluation of the mass with fine-needle aspiration did not show malignant cells while diagnostic surgery and histological assessment revealed neoplastic lymphoproliferation. The final diagnosis was a non-Hodgkin B-cell lymphoma. Chemo- and immunotherapy were initiated. Follow-up abdominal computed tomography revealed significant remission of the retroperitoneal mass. Initially, the retroperitoneal mass was highly suspicious for RF. While imaging can be useful, obtaining histology should always be considered when there is an uncertain clinical presentation. Without histology, we would have missed a non-Hodgkin B-cell lymphoma in this case. Minimally invasive techniques such as fine-needle aspiration may be practical but can give false-negative results.
Gentamicin-Montmorillonite Intercalation Compounds as an Active Component of Hydroxypropylmethylcellulose Bionanocomposite Films with Antimicrobial Properties
Authors: Darder Margarita , He Jing , Charlet Laurent , Ruiz-Hitzky Eduardo , Aranda Pilar 
Published: January 2022

AbstractThe present study introduces an overview of gentamicin-clay mineral systems for applications in biomedicine and then focuses on the development of a series of gentamicin/clay hybrid materials to be used as the bioactive phase of hydroxypropylmethylcellulose (HPMC) to produce bionanocomposite membranes possessing antimicrobial activity of interest in wound-dressing applications. Gentamicin (Gt) was adsorbed from aqueous solutions into a montmorillonite (Cloisite®-Na+) to produce intercalation compounds with tunable content of the antibiotic. The hybrids were characterized by CHN chemical analysis, energy-dispersive X-ray analysis, X-ray diffraction, Fourier-transform infrared spectroscopy, and thermogravimetric analysis, confirming the intercalation of Gt by an ion-exchange mechanism. The release of Gt from the hybrids was tested in water and in buffer solution to check their stability. Hybrids with various amounts of Gt were incorporated into a HPMC matrix at various loadings and processed as films by the casting method. The resulting Gt-clay/HPMC bionanocomposites were characterized by means of field-emission scanning electron microscopy, and were also evaluated for their water-adsorption and mechanical properties to confirm their suitability for wound-dressing applications. The antimicrobial activity of the bionanocomposite films was tested in vitro toward various microorganisms (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium, Acinetobacter baumannii, and Klebsiella pneumonia), showing a complete bacterial reduction even in films with small Gt contents.