bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of the Postoperative Outcomes Between Intraoperative Leak Testing and Non-Intraoperative Leak Testing for Gastric Cancer Surgery: A Systematic Review and Meta-analysis
Authors: Tian Yunhong , Liu Shunying , Bai Dan , Qi Shouliang , Wesemann Luke , Qin Xiangzhi , Huang Wentao , Peng Yong , Ren Mingyang , Hu Jiani 
Published: March 2022

Abstract
Purpose
Postoperative anastomotic leakage (PAL) is a serious complication of gastric cancer surgery. Although perioperative management has made significant progress, anastomotic leakage (AL) cannot always be prevented. Intraoperative leak testing (IOLT) may reduce the incidence of PAL and other postoperative complications. The aim of this study is to assess the relationship between IOLT and postoperative surgical complications in gastric cancer surgery.
Materials and methods
In this meta-analysis, we searched the PubMed, Embase, and Cochrane Library databases for clinical trials to assess the application of IOLT in gastric cancer surgery. Studies comparing the postoperative outcomes of IOLT and non-intraoperative leak testing (NIOLT) were included. Quality assessment, heterogeneity, risk of bias, and the level-of-evidence of the inclusions were evaluated. PAL, anastomosis-related complications, 30-day mortality, and reoperation rates were compared between the IOLT and NIOLT group.
Results
Our literature search returned 975 results, from which 3 trials (929 total patients) were included in our meta-analysis. Statistical heterogeneity was low. The primary outcome was PAL. IOLT statistically reduced the risk of PAL [3.08% vs9.54%; risk ratios (RR) 0.336, 95% CI, 0.189–0.600, P = 0.000]. It was also found that IOLT can lower the incidence of other postoperative outcomes. Anastomosis-related complication rates [3.94% vs13.14%; risk ratios (RR) 0.323, 95% CI, 0.182–0.572, P = 0.000] were significantly higher in the NIOLT group than the IOLT group. Moreover, IOLT was associated with lower reoperation rates [2.36% vs9.14%; risk ratios (RR) 0.301, 95% CI, 0.145–0.621, P = 0.001].
Conclusion
Due to the lower incidence of PAL, anastomosis-related complications, and reoperation rates, IOLT is recommended in gastric cancer surgery.
Bio-inspired ,Strong, Flexible Lignin/Cellulose Film with UV-Blocking, Water-Stable and Antioxidant Properties.
Authors: Liu Liangxian , Cui Boyu , Li Shuang , Liu Chaodong , Tan Lei , Weihong Wang 
Published: March 2022

Abstract
The use of low-cost, efficient methods to prepare thin-film materials to partially replace conventional materials in new applications is appealing. In this work, inspired by natural biological materials, we propose a strategy to prepare lignin/cellulose film with excellent strength and flexibility by building a sacrificial network. Coordination bonds and hydrogen bonds were constructed by ultrasonic treatment and the addition of ZnCl2 to lignin/cellulose films. The resulting films exhibited a tensile strength of up to 138.14 MPa, elongation at break of 14.78%, and folding resistance of 2,687 times, allowing it to be folded into complex shapes. Due to the addition of functional industrial waste lignin, the film displayed UV-blocking, water-stable, and antioxidant properties. The lignin/cellulose film is expected to be used in several new fields such as UV-blocking polymers and flexible integrated circuit boards in emerging electronics.
Face-to-face versus distance learning of basic suturing skills in novice learners: A quantitative prospective randomized trial
Authors: Zaghal Ahmad , Marley Charles , Rahhal Salim , Hassanieh Joelle , Saadeh Rami , El-Rifai Arwa , Qaraqe Taha , Bejjani Martine , Jaafar Rola , Hoballah Jamal J. 
Published: March 2022

Abstract
Background and aimTraditionally, practical skills are taught on face-to-face (F-F) basis. COVID-19 pandemic brought distance learning (DL) to the spotlight because of the social distancing mandates. We sought to determine the acceptability and effectiveness of DL of basic suturing in novice learners. MethodsA prospective randomized controlled trial involving 118 students was conducted. Participants were randomized into two groups for learning simple interrupted suturing: F-F and DL-groups. Evaluation was conducted by two assessors using a performance checklist and a global rating tool. Agreement between the assessors was calculated, and performance scores of the participants were compared. Participants’ satisfaction was assessed via a questionnaire.Results 59 students were randomized to the F-F group and 59 to the DL-group. Satisfactory agreement between the assessors was demonstrated. All participants were successful in placing three interrupted sutures, with no significant difference in the performance between the groups. 25(44.6%) of the respondents in the DL-group provided negative comments related to the difficulties of remotely learning visuospatial concepts, 16(28.5%) preferred the F-F approach.ConclusionDL of basic suturing is as effective as the F-F approach in novice learners. It is acceptable by the students despite the challenges related to the remote learning of practical skills.
Effects of Different Treatment Regimens on Primary Spontaneous Pneumothorax: A Systematic Review and Network Meta-Analysis
Authors: Muhetaer Muredili , Paerhati Keriman , Sun Qingchao , Li Desheng , Zong Liang , Zhang Haiping , Jing Xiaoliang , Zhang Liwei 
Published: March 2022

Abstract

Background: The best treatment strategy for primary spontaneous pneumothorax is controversial and varies widely in practice, so we conducted a systematic review and network meta-analysis to clarify which treatment is optimal. Methods: Literatures were searched from relevant databases till 24 August 2021. A Bayesian network meta-analysis was conducted to compare the outcomes of various treatment regimens with the following endpoints: recurrence rate; postoperative chest tube duration; postoperative air leakage duration; length of hospital stay and rate of complications. The surface under the cumulative ranking curve was used to rank the treatments. Results: 7210 patients of 20 randomized controlled trials and 17 cohort studies were included. In terms of recurrence reduction, there was no significant difference between any pairs of conservative treatment, manual aspiration and chest tube drainage. Surgical methods had a significantly lower recurrence rate compared to manual aspiration and chest tube drainage. Besides, bullectomy combined with additional procedures such as chemical pleurodesis, mechanical pleuodesis or staple line coverage can reduced the recurrence rate of PSP compared to bullectomy along, but none of them were statistically significant. In terms of reducing postoperative chest tube duration, “bullectomy with tubular Neoveil” outperformed “bullectomy + pleural abrasion” (MD, 95%CI: -2.5[-4.63, -0.35]) and “bullectomy + apical pleurectomy” (MD, 95%CI: -2.72[-5.16, -0.27]).Conclusions: Surgical methods were superior to manual aspiration, chest tube drainage and conservative treatment in terms of recurrence reduction. There was no significant difference between manual aspiration and chest tube drainage in reducing recurrence rate, but manual aspiration was linked to a shorter hospital stay and a lower rate of complications. Conservative treatment is an acceptable alternative to chest tube drainage or manual aspiration due to similar recurrence rates but lower incidence of complications. Among surgical methods, chemical pleuodesis is more effective than mechanical pleuodesis and staple line coverage among the additional procedures based on bullectomy. Moreover, bullectomy with tubular Neoveil was superior to bullectomy along. However, more randomized controlled trials are needed to confirm these findings and raise the level of evidence.Registration: The protocol was registered with PROSPERO (CRD42021236922).
Reinforcement of Cellulose Nanofibers On the Stiffness and Strength of Composite Sheets Under Dry and Wet Conditions
Authors: liu haoyue , Yano Hiroyuki , Abe Kentaro 
Published: March 2022

Abstract
The objective of this study was to evaluate how a wide range (0–100%) of cellulose nanofiber (CNF) addition affects the mechanical properties of composite sheets made of bleached pulp fibers and CNFs. It was found that adding CNFs could reduce the porosity of the sheets, thus increasing the dry Young’s modulus within the CNF addition range of 0–100%, whereas the dry specific Young’s modulus of all the sheets was constant. The dry tensile strength of the sheets increased as the CNF addition increased to 70% because of the increased hydrogen bond density between the pulp fibers. However, there was no further improvement in the dry tensile strength when the CNF addition was more than 70%. Although the wet Young’s modulus decreased when the CNF addition was more than 20% owing to the increase in the thickness of the sheets, the wet tensile strength of the sheets increased almost linearly as more CNFs were added up to 70%, and the maximum wet strength retention reached nearly 10% at 40% CNF addition.
Topsoil Carbon Stocks in Urban Greenspaces of The Hague, the Netherlands
Authors: Kortleve Anniek J , Mogollón José M , Heimovaara Timo J , Gebert Julia 
Published: March 2022

Abstract
This research studied soil C storage in urban greenspaces in the Dutch city of The Hague along a transect from the suburban seaside towards the city centre, reflecting a toposequence from sandy dune soils to peaty inland soils. C storage and C mineralisation potential were evaluated in relation to soil type and properties, land ownership, type of vegetation, litter management and eco-zone status. Several soil quality characteristics were measured, including dissolved organic C, pH, electrical conductivity, nitrogen, phosphorus, sulphur, calcium carbonate, and the water-holding capacity of the soil.The total soil C storage of the upper 30 cm of the greenspaces in The Hague was estimated at 23.5 kt. Degradability of soil organic matter in laboratory batch tests varied between 0.2 and 2 mg C gSOC-1 d-1. Degradability was highest in the seaside dune soils; however, extrapolated to the top 30 cm using C density, potential C mineralization was higher in the urban forest. Soils beneath shrubs appeared to be hotspots for C storage, accounting for only 13% of the aerial cover but reflecting almost a quarter of the total C storage. Along the transect, a mean soil C density of 110 t ha-1 was measured, of which 98 t ha-1 was organic C. Land ownership, use, and soil type did not result in significantly different C stocks, suggesting that processes driving urban soil C storage are controlled by different factors, namely the type of vegetation and the urbanization extent.
3D printed porous titanium filled with mineralized UV-responsive chitosan hydrogel promote cell proliferation and osteogenesis in vitro
Authors: Yang Jiazhao , Zhou Changshun , Liu Fan , Li Hejie , Yang Gaolin , Fang Shiyuan , Lee In-seop , Chen Cen 
Published: March 2022

Abstract
Background: The modification of 3D printed porous titanium (Ti) have received significant attention to promote its osteogenesis for clinical use. Methods: Ultra-violet (UV) responsive chitosan (CSMA), as an injectable filling material, was incorporated into porous Ti, and in situ mineralized by carbon oxide (CO2) diffusion to form mineralized CSMA (CSMA/CaCO3). Physiochemical and biological properties were investigated in vitro . Results: CMSA/CaCO3 exhibited porous morphology and favorable biocompatibility, which could promote adhesion and proliferation of bone mesenchymal stem cells (BMSCs). Moreover, the release of Ca2+ from CaCO 3 particles could increase alkaline phosphatase (ALP) activities, up-regulate osteopontin (OPN) and osteocalcin (OCN) expression levels, and enhance extracellular mineralization of BMSCs. Conclusions: 3D printed porous Ti filling with mineralized UV-responsive chitosan hydrogel could promote proliferation and osteogenesis of BMSCs, and have great potential for Ti implant modification in bone tissue engineering.
Effects of lidocaine via the perforated outer cuff of dual-cuff endotracheal tube and remifentanil on the recovery profiles from general anesthesia of female patients undergoing thyroidectomy: an one-centre, double-blind, randomized study
Authors: Li Ping , Li Dewei , Wang Linan , Ye Fei , Yang Bo , Yu Lina , Fang Sujuan , Tong Zhilan , Yin Qing , Shi Yongyong , Li Xiangyu , Zhao Gaofeng 
Published: March 2022

Abstract
Background: Cough caused by endotracheal tube (ETT) is ubiquitous and correlates with adverse outcomes. Remifentanil via target-controlled infusion (TCI) was one of cough prevention measures during recovery. In the pilot study, lidocaine via the perforated outer cuff of dual-cuff endotracheal tube also prevented cough to the ETT. We therefore compared these two preventions of cough during recovery after thyroidectomy in the one-centre, double-blind, randomized study in China from 09 / 10 / 2020 to 30 / 04 / 2021.Methods: Ninety-eight female patients, aged 18–65 years, with an American Society of Anesthesiologists I and II, were scheduled to undergo thyroidectomy. The ETT contains an internal cuff covered by an outer cuff with holes as lidocaine delivery channel. Patients were randomized to receive either 4 ml saline solution (Group R, n = 49) or 4 ml 2% lidocaine in the outer cuff (Group L, n = 49) at the beginning of the skin suture. Remifentanil 2 ng/ ml in Group R was maintained until extubation, while remifentanil in Group L was maintained until the end of the skin suture. The primary outcome was cough during patient transfer, 1 min before extubation and extubation. The secondary outcomes were hemodynamics and other recovery profiles. Results: The primary outcomes included remifentanil vs. lidocaine in the incidence of cough during patients transfer (0% vs.0%), 1 min before extubation (22% vs. 4%; P = 0.015), and extubation (61% vs.20%; P = 0.000). Compared with remifentanil, lidocaine more effectively decreased the rate of elevation of heart rate and hypoxemia at 5 min after extubation, spontaneous respiration recovery time, extubation time, duration of post-anesthesia care unit (PACU), and Richmond Agitation-Sedation Scale in agitated and Critical-Care Pain Observation Tool. Conclusion: Lidocaine via the perforated outer cuff of the ETT significantly improved recovery profiles from general anesthesia compared to remifentanil in female patients after thyroidectomy.Trial registration: Chinese Clinical Trial Registry (No. ChiCTR2000038653), registered on 27 / 09 / 2020.
Anti-microbial effect of filtered 222nm excimer lamps in a hospital waiting area
Authors: Thyrsted Jacob , Skaarup Søren Helbo , Hvass Andreas Fløe , Joensen Sara Moeslund , Nielsen Stine Yde , Bendstrup Elisabeth , Hauschildt Pernille , Holm Christian Kanstrup 
Published: March 2022

Abstract
Hospital aquired infections is a considerable challenge for vulnerable patients. Traditional anti-microbial mercury lamps emit light at 254nm and have well established anti-microbial effects. Their use in populated areas is, however, hindered by their carcinogenic properties. This is in contrast to anti-microbial lamps based on krypton chloride (KrCl), demonstrated to have no carcinogenic potential. These lamps emit light with a peak intensity at 222nm and have broad bactericidal and viricidal effects including inactivation of SARS-CoVid-2 in laboratory experiments. Here, we investigate the bactericidal effects of filtered KrCl 222nm excimer lamps (UV222 TM lamps) in an out-patient waiting area at the pulmonology clinic at Aarhus University Hospital. Furniture sufaces were sampled for bacterial load in a single-arm interventional longitudinal study with and without exposure to filtered 222nm UVC-light. Furthermore, bacterial species were identified using MALDI-ToF mass-spectrometry. We found filtered 222nm UVC-light to significantly reduced the number of colony-forming-units. Pathogenic bacteria such as Staphylococcus aureus and Staphylococcus epidermidis were detected only in the non-exposed areas suggesting that these species in particular are highly sensitive to inactivation by 222nm UVC-light. This study demonstrates the potential use of 222nm Far-UVC technology to reduce bacterial load and thus the spread of infectious disease in a hospital setting.
Analysis Of Related Factors Of Scheduled ICU Before Primary Hip Arthroplasty
Authors: Sun Jianguang , Yang Yali , Feng Gui , Liang Chuanxing , Ling Weiming , Liao Hongxin 
Published: March 2022

Abstract
Background: Methods for improving the safety of medical treatments for patients, reducing the occurrence of postoperative complications and optimizing medical resources for primary hip replacement are needed. Previous literature has mostly analysed the risk factors and constructed and models to predict a transfer to the ICU after surgery, and no reports on preoperative ICU reservations have been found. This study evaluated the risk factors for preoperative ICU reservation and considered the necessity of preoperative ICU reservations to optimize preoperative communication, enable a seamless transfer between the operating room and ICU, reduce postoperative complications and shorten hospital stays.Methods: We extracted the data of 1488 patients who underwent initial hip replacement from the hospital case database from November 2017 to May 2021 and used the case–control test to divide the patients into the case group (scheduled ICU admission, 134 cases) and the control group (unscheduled ICU admission, 213 cases). The general conditions of the patients before surgery, including sex, age, comorbidity index, laboratory test results, and anaesthesia methods, were collected and used as independent variables. The t test, rank sum test, and X2 test were used to analyse and identify significant factors with a P < 0.05. Then, these factors were entered into binary logistic regression analysis, and a ROC curve was used to test the efficacy of the regression model.Results: Through logistic regression analysis, we identified the risk factors for preoperative ICU reservation in patients who underwent primary total hip arthroplasty. Age, use of general anaesthesia, preoperative C-reactive protein level and preoperative alanine aminotransferase level were risk factors for preoperative ICU reservation, and preoperative albumin level was a protective factor against preoperative ICU reservation.Conclusion: These risk factors help surgeons assess the patient's condition and contact the ICU in advance; these data can be fully understood by the patients' families, reduce the unnecessary use of medical resources, and optimize perioperative management.
Perioperative Control Of Acute High Blood Pressure In Neurosurgical Patients Admitted To Intensive Care Unit Using Clevidipine (Neuro-Clev)
Authors: Rodriguez Blanca Escontrela , Arana-Arri Eunate , Boedo Maria Jesus Maroño , Ruiz Alberto Martinez 
Published: March 2022

Abstract
Background: Effective treatment of acute high blood pressure in neurocritical diseases is a current recommendation of guidelines to reduce mortality and severe disability. Clevidipine is a calcium channel blocker that showed effectiveness and safety for acute high blood pressure control in neurocritical patients. Materials and methods: Retrospective, observational and cross-sectional study in adult patients admitted to Intensive Care Unit for neurocritical disease requiring surgical or interventional treatment and presenting acute high blood pressure requiring urgent treatment with clevidipine as first line or rescue therapy after failure of different intravenous antihypertensive drugs. Primary endpoint was effectiveness of clevidipine treatment. Secondary endpoint was safety of clevidipine treatment. Analysis of subgroups described patient and treatment variables on effectiveness and safety of clevidipine, mortality, functional situation and major neurologic complications. Hematoma expansion, rebleeding and vasospasm were specific neurological complications described. Comparisons was made using Fisher, chi-square, t or Mann Whitney U test. Significance was set at the 5% level. Analysis was made using IBM SPSS Statistics 23.0 Results: thirty-three patients admitted to Intensive Care Unit fulfilled inclusion criteria and were included. Clevidipine showed a higher effectiveness and safety for acute high blood pressure control in our patients. Effectiveness was higher in patients with larger brain hematomas and severe aneurysmal subarachnoid hemorrhages treated with first line and early began of clevidipine within 24 hours of admission. Adverse events were mild, transient and more frequent in patients with first line treatment. Early and effective treatment were safe with lower major neurological complications. Mortality was lower in patients with first line and effective treatment. Hematoma expansion was seen in a higher number of patients. Rebleeding and vasospasm were less frequent. Conclusion: Clevidipine was effective and safe treatment of acute high blood pressure in neurocritical patients. Severity of neurocritical disease is a key factor but early and effective treatment could contribute to reduce mortality and major neurological complications. Nevertheless, our results need to take with caution because little size and design of our study. Trial registration: NCT05168059
Numerical Analysis Of Dynamic Coupling Between The Keyhole And Molten Pool In The Rotating Laser Welding Process Of Aluminum Alloy
Authors: Wang Xueli , Liu Wen , Xu Guoxiang , Zhu Jie , Hu Qingxian , Du Baoshuai 
Published: March 2022

Abstract
The stirring effect of a rotating laser on a molten pool can expand the range of the laser heat source and effectively inhibit defects such as pores and improve the quality of the weld joint. Due to laser rotation, the physical characteristics of the heat source and the dynamic behavior of the keyhole and molten pool are more complicated than those of conventional laser welding. This paper adopts a numerical simulation method. A three-dimensional model is developed, which takes into account the coupling of the keyhole, recoil pressure and molten pool. The model can describe the dynamic behavior characteristics of keyholes and fluid flow and the formation process and mechanism of keyhole-induced pores in welds during rotating laser welding. It can be concluded that in conventional laser welding, the keyhole is deep, narrow and unstable, which usually results in the formation of bubbles. If the bubbles in the molten pool fail to overflow in time, pores are formed. With an increase in laser rotation frequency, the keyhole becomes shallow and wide, and the dynamic behavior of the keyhole tends to be stable, which can effectively inhibit the formation of pores. When the rotating frequency is increased up to 150 Hz, the formation of pores can be completely suppressed.