bluuebunny/crossref_metadata_2025_split huggingface dataset:
The use of trap‐nests to support crop pollinators in agricultural areas
Authors: Gilpin Amy‐Marie , Brettell Laura E. , Cook James M. , Power Sally A. 
Published: July 2022

AbstractSupporting and promoting invertebrate diversity within agricultural ecosystems has numerous benefits, including the provision of pollination services. Many insects, including wild pollinators, require floral resources for food and structural habitat for nesting. To support pollinators, research studies and agri‐environment schemes have sought to supplement floral resources, but little is known about the value of different types of nesting habitat enhancements (e.g., trap‐nests or bee hotels). We deployed eight replicates of each of three types (bamboo reed, hardwood block and sand/cement brick) of trap‐nests at five orchards in two apple and cherry growing regions (Bilpin and Orange) in Australia. Both reed and hardwood block trap‐nests attracted a diverse array of invertebrates, such as ants, wasps, spiders and bees, including a cleptoparasitic bee species (Thyreus sp.) not previously recorded in the region. Interestingly, two taxa of native bees (Megachile [Megachile] and Megachile [Eutricharaea]) used the artificial nests and were also observed visiting apple crops. There were significantly more native bees using trap‐nests in Orange (n = 65), where orchards are surrounded by agricultural landscapes, than in Bilpin (n = 2), where orchards are surrounded by native forests. Our findings show that artificial nest enhancements are used by native bees, as well as other nontarget invertebrate taxa, some of which can be predators of bees (ants, wasps, and spiders). Nesting habitat augmentation thus has potential to be used as a conservation tool, especially in areas where nesting sites are limited. However, future studies should also consider measures to reduce colonization by non‐target taxa.
Potentially avoidable emergency department transfers from residential aged care facilities for possible post‐fall intracranial injury
Authors: Tulchinsky Igor , Buckley Richard , Meek Robert , Lim Joel Jun Yi 
Published: July 2022

AbstractObjectivesTo determine the percentage of potentially preventable residential aged care facility (RACF) to ED transfers for potential intracranial injury post‐fall. To describe rates of CT brain (CTB) performance, intracranial trauma‐related findings, neurosurgical intervention, and patient outcome.MethodsPatient lists were obtained from the hospital electronic medical record, screened for eligibility and data abstracted. Potentially preventable was defined as: (1) RACF return from ED within 24 h, regardless of CTB performance or finding; (2) ED management could reasonably have been provided at the RACF. Comparisons between those with CTB performed or not, including external signs of craniofacial trauma, anticoagulant medication use, baseline cognitive impairment and presence of an advanced care directive (ACD) were made.ResultsOf 784 patients, 415 (53%) were classified as potentially avoidable. Of these, 314 (76%) had a CTB. Of all 784 patients, 538 (69%) had a CTB performed. CTB was more likely with presence of external signs of craniofacial trauma (26% [95% CI 23–30] vs 20% [95% CI 15–25], P < 0.001) and anticoagulant use (59% [95% CI 55–63] vs 42% [95% CI 37–49], P < 0.001) but not for presence of cognitive impairment or ACD. From the 538 CTBs, 31 (6%) patients had acute intracranial trauma‐related findings with all having conservative management. None of the 11 (1%) deaths were in the potentially preventable subgroup.ConclusionJust over half of the RACF to ED transfers were classified as ‘potentially avoidable’.
Effects of nitrite concentrations on the quality and protein oxidation of salted meat
Authors: Wang Xinyue , Yu Qunli , He Long , Zhang Qing , Ma Jibing 
Published: July 2022

AbstractThe objective of this study was to investigate the effects of different concentrations of sodium nitrite on the quality and protein oxidation of salted meat during 21 days of curing. The salted meat was treated with sodium nitrite at 50, 100, and 150 mg/kg for curing, and salted meat without sodium nitrite was used as a control. The results showed that in salted meat added with sodium nitrite, the carbonyl group, disulfide bond, dityrosine, surface hydrophobicity, and the transformation rate from α‐helix to β‐sheet were all significantly reduced, whereas the sulfhydryl group content of myofibrillar proteins was significantly increased compared to the control. Meanwhile, the total volatile basic nitrogen and aerobic plate content were significantly decreased, while both the pH and a* value were significantly increased with an increase in nitrite concentration compared to the control group. Importantly, this phenomenon was also observed in salted meat treated with low doses of sodium nitrite (50 mg/kg). In conclusion, the quality of salted beef can be improved by adding low‐dose sodium nitrite to inhibit protein oxidation during the curing process.Practical ApplicationA low dose of sodium nitrite inhibited the rate of α‐helix to β‐sheet transformation of myofibrillar proteins in salted meat, reducing the exposure of hydrophobic groups and decreasing the production of protein oxidation products and TVB‐N to improve the quality of salted meat. These results provided a theoretical basis and technical guidance for the application of low‐dose sodium nitrite in meat processing enterprises.
Hermetia illucens L. larvae–associated intestinal microbes reduce the transmission risk of zoonotic pathogens in pig manure
Authors: Zhang Yuanpu , Xiao Xiaopeng , Elhag Osama , Cai Minmin , Zheng Longyu , Huang Feng , Jordan Heather R. , Tomberlin Jeffery K. , Sze Sing‐Hoi , Yu Ziniu , Zhang Jibin 
Published: July 2022

AbstractBlack soldier fly (BSF) larvae are considered a promising biological reactor to convert organic waste and reduce the impact of zoonotic pathogens on the environment. We analysed the effects of BSF larvae on Staphylococcus aureus and Salmonella spp. populations in pig manure (PM), which showed that BSF larvae can significantly reduce the counts of the associated S. aureus and Salmonella spp. Then, using a sterile BSF larval system, we validated the function of BSF larval intestinal microbiota in vivo to suppress pathogens, and lastly, we isolated eight bacterial strains from the BSF larval gut that inhibit S. aureus. Results indicated that functional microbes are essential for BSF larvae to antagonise S. aureus. Moreover, the analysis results of the relationship between the intestinal microbiota and S. aureus and Salmonella spp. showed that Myroides, Tissierella, Oblitimonas, Paenalcalignes, Terrisporobacter, Clostridium, Fastidiosipila, Pseudomonas, Ignatzschineria, Savagea, Moheibacter and Sphingobacterium were negatively correlated with S. aureus and Salmonella. Overall, these results suggested that the potential ability of BSF larvae to inhibit S. aureus and Salmonella spp. present in PM is accomplished primarily by gut‐associated microorganisms.
Characteristics and risk factors of severe coronary artery disease in systemic lupus erythematosus: A multicenter, Chinese Rheumatism Date Center database study
Authors: Ci Weiping , Zhao Jiuliang , Qi Wanting , Gao Na , Qian Junyan , Zhang Guohua , Wang Yuhua , Pan Lili , Li Mengtao 
Published: July 2022

AbstractAimSystemic lupus erythematosus (SLE) with severe coronary artery disease (CAD) is associated with increased mortality. This study aimed to assess the characteristics and risk factors of severe CAD in SLE.MethodThis multicenter, cross‐sectional study enrolled consecutive patients with SLE included in the Chinese Rheumatism Date Center registry. Patients with severe CAD including angiography‐confirmed stenosis ≥50% in the left main, ≥70% in other major coronary arteries, or myocardial infarction were classified into the CAD group. Patients without CAD were classified into the control group. Subgroups were stratified according to age (set as above and below 45 and 50 for men and women, respectively) and gender. Binary logistic regression analysis was performed to determine independent risk factors of severe CAD in SLE.ResultsForty‐three patients had severe CAD from a total of 3744 patients with SLE, 30 of whom were female; 35 belonged to the older age group and 8 belonged to the younger age group. In older patients, independent risk factors included age, 5 major CAD risk factors, SLE Disease Activity Index 2000 (SLEDAI‐2K), hyperuricemia, and corticosteroid exposure. In younger patients, the risk factors were 5 major CAD risk factors and positive antiphospholipid antibody (APL). Male risk factors were age and 5 major CAD risk factors, whereas female risk factors were age, 5 major CAD risk factors, SLEDAI‐2K, and positive APL. Three‐vessel disease was most prevalent in patients with severe CAD.ConclusionWe recommend screening for severe CAD in patients with SLE with age‐ and gender‐stratified risk factors.
Physical activity behaviors in cancer survivors treated with neurotoxic chemotherapy
Authors: Mizrahi David , Goldstein David , Trinh Terry , Li Tiffany , Timmins Hannah C. , Harrison Michelle , Marx Gavin M. , Hovey Elizabeth J. , Lewis Craig R. , Friedlander Michael , Park Susanna B. 
Published: July 2022

AbstractAimThere are many barriers to physical activity among cancer survivors. Survivors treated with neurotoxic chemotherapy may develop chemotherapy‐induced peripheral neuropathy (CIPN) and experience additional barriers related to sensorimotor and mobility deficits. This study examined physical activity behaviors, including physical activity predictors, among cancer survivors treated with neurotoxic chemotherapies.MethodsA cross‐sectional study of 252 participants, 3–24 months after neurotoxic chemotherapy, was undertaken. Physical activity was self‐reported (IPAQ). CIPN was self‐reported (FACT/GOG‐Ntx‐13), clinically graded (NCI‐CTCAE), and objectively measured using neurological grading scales and neurophysiological techniques (tibial and sural nerve conduction studies). Balance (Swaymeter) and fine motor skills (grooved pegboard) were assessed. Regression models were used to identify clinical, demographic and CIPN predictors of walking and moderate–vigorous physical activity.ResultsForty‐four percent of participants did not meet recommended physical activity guidelines (≥150 min/week). Sixty‐six percent presented with CIPN. Nineteen percent of participants with CIPN reported that symptoms interfered with their ability to be physically active. A lower proportion of survivors aged ≥60, with grade ≥1 CIPN or BMI ≥30, reported meeting physical activity guidelines (all p < .05). Regression models identified older age, higher BMI, and patient‐reported CIPN associated with lower walking, while higher BMI and females were associated with lower moderate–vigorous physical activity. Neurologically assessed CIPN did not associate with walking or moderate–vigorous physical activity.ConclusionCancer survivors exposed to neurotoxic chemotherapy have low physical activity levels. Further work should examine the factors causing physical activity limitations in this cohort and designing interventions to improve physical function and quality of life in survivors.
Dynamic changes of intracellular zinc ion level during maturation, fertilization, activation, and development in mouse oocytes
Authors: Kageyama Atsuko , Suyama Ayumi , Kinoshita Ruka , Ito Junya , Kashiwazaki Naomi 
Published: July 2022

AbstractAlthough it is well known that calcium oscillations are required for fertilization in all mammalian species studied to date, recent studies also showed the ejection of zinc into the extracellular milieu in a series of coordinated events, called “zinc spark,” during mammalian fertilization. These results led us to the hypothesis that a zinc ion‐dependent signal is important for oocyte maturation, fertilization (activation), and further embryonic development. In this study, we evaluated the amounts and localization of intracellular zinc ions during maturation, fertilization, activation, and embryonic development in mouse oocytes. Our results show that abundant zinc ions are present in both immature and mature oocytes. After in vitro fertilization, the amounts of zinc ions were dramatically decreased at the pronuclear (PN) stage. Artificial activation by cycloheximide, SrCl2, and TPEN also reduced the amounts of zinc ions in the PN stage. On the other hand, PN embryos derived from sperm injection still showed high level of zinc ions. However, the amounts of zinc ions rapidly increased at the blastocysts regardless of activation method. We showed here that the amounts of zinc ions dramatically changed during maturation, fertilization, activation, and development in mouse oocytes.
Tectono‐sedimentary development of early synrift half‐graben subbasins in the Miocene Pohang Basin, southeastern Korea
Authors: Park Jino , Lee Jeong‐Hyun , Hong Jongsun 
Published: July 2022

AbstractEarly synrift half‐grabens, herein named the Chilpo and Sinheung subbasins, have been newly recognised in the north‐central area of the Miocene Pohang Basin, Korea. The subbasins are closely aligned along an array of NNW‐trending strike‐slip faults and are bounded by ENE‐striking normal faults. The sediment infill of the subbasins consists of a deepening‐ and fining‐upward sequence of alluvial cobble to boulder conglomerate (FA1), alluvial to nearshore granule to pebble conglomerate and sandstone (FA2) and hemipelagic mudstone (FA3). The younger strata sequentially onlap the older strata in the hangingwall basement or transfer zones, whereas the footwall basement is directly onlapped by the younger hemipelagic mudstone. These patterns may have resulted from a series of domino‐style block rotations, in which subsidence along normal faults caused the differential creation of accommodation space, whilst simultaneous uplift in the upslope of rotated hangingwall blocks controlled denudation, the shedding of sediments to downslope areas and asymmetric stacking of sediments in both subbasins. In contrast to the western margin of the Pohang Basin, where large footwall‐derived fan‐delta systems developed along the bounding faults, in the Chilpo and Sinheung subbasins, small hangingwall‐derived alluvial‐fan deltas formed during rifting. The development of these domino‐style half‐grabens would have resulted from the detachment and simultaneous transrotation of the crustal block away from the northwest during accelerated extension in the Pohang Basin. Recent geophysical studies have detected very thin basin‐fill sediments in the north‐central Pohang Basin and faults that are similar in orientation to those identified in this study, thereby supporting our observations. These findings confirm the early opening of the Pohang Basin, supporting the hypothesis that all of the Miocene basins in southeastern Korea formed in a setting of NW–SE extension, and further suggest the development of the wedge‐shaped transtensional basin, in response to the opening of the East Sea (Sea of Japan) after 17 Ma.
Establishment of a deep‐learning system to diagnose BI‐RADS4a or higher using breast ultrasound for clinical application
Authors: Hayashida Tetsu , Odani Erina , Kikuchi Masayuki , Nagayama Aiko , Seki Tomoko , Takahashi Maiko , Futatsugi Noriyuki , Matsumoto Akiko , Murata Takeshi , Watanuki Rurina , Yokoe Takamichi , Nakashoji Ayako , Maeda Hinako , Onishi Tatsuya , Asaga Sota , Hojo Takashi , Jinno Hiromitsu , Sotome Keiichi , Matsui Akira , Suto Akihiko , Imoto Shigeru , Kitagawa Yuko 
Published: July 2022

AbstractAlthough the categorization of ultrasound using the Breast Imaging Reporting and Data System (BI‐RADS) has become widespread worldwide, the problem of inter‐observer variability remains. To maintain uniformity in diagnostic accuracy, we have developed a system in which artificial intelligence (AI) can distinguish whether a static image obtained using a breast ultrasound represents BI‐RADS3 or lower or BI‐RADS4a or higher to determine the medical management that should be performed on a patient whose breast ultrasound shows abnormalities. To establish and validate the AI system, a training dataset consisting of 4028 images containing 5014 lesions and a test dataset consisting of 3166 images containing 3656 lesions were collected and annotated. We selected a setting that maximized the area under the curve (AUC) and minimized the difference in sensitivity and specificity by adjusting the internal parameters of the AI system, achieving an AUC, sensitivity, and specificity of 0.95, 91.2%, and 90.7%, respectively. Furthermore, based on 30 images extracted from the test data, the diagnostic accuracy of 20 clinicians and the AI system was compared, and the AI system was found to be significantly superior to the clinicians (McNemar test, p < 0.001). Although deep‐learning methods to categorize benign and malignant tumors using breast ultrasound have been extensively reported, our work represents the first attempt to establish an AI system to classify BI‐RADS3 or lower and BI‐RADS4a or higher successfully, providing important implications for clinical actions. These results suggest that the AI diagnostic system is sufficient to proceed to the next stage of clinical application.
Sjögren‐Syndrom
Authors: André Fiona , Böckle Barbara C. 
Published: July 2022

ZusammenfassungDas Sjögren‐Syndrom (SjS) ist eine Autoimmunerkrankung aus dem Formenkreis der Kollagenosen, die durch die Trias Sicca‐Symptomatik, Fatigue und Schmerz charakterisiert ist. Die Diagnose wird meist bei Frauen und oft erst spät, im Alter von durchschnittlich 60 Jahren, gestellt. Bei mehr als drei Monate andauernder Sicca‐Symptomatik, die durch andere Differenzialdiagnosen nicht erklärbar ist, können die ACR/EULAR 2016 Klassifikationskriterien für das SjS angewendet werden, um die Diagnose zu stellen. Im Rahmen des SjS können viele Organe betroffen sein. Die Xerosis cutis und der Pruritus sind die häufigsten Hautmanifestationen. Oftmals werden eine leukozytoklastische Vaskulitis und ein subakut kutaner Lupus erythematodes bei SjS‐Patienten diagnostiziert. Zusätzlich haben SjS‐Patienten häufig Myoarthralgien sowie neuropsychiatrische Symptome. Langfristig muss auf das erhöhte Risiko für kardiovaskuläre Erkrankungen sowie Lymphome geachtet werden. Aufgrund der Beteiligung vieler Organe bei SjS‐Patienten ist ein interdisziplinärer Behandlungsansatz erforderlich.
Relations between childhood emotional insecurity, self‐esteem, and adulthood marital conflict in South Korea
Authors: Lee Young‐Eun 
Published: July 2022

AbstractObjectiveThis study examined the reciprocal relationship between childhood emotional insecurity, later adult self‐esteem, and marital conflict in South Korean couples.BackgroundCurrent literature on intergenerational transmission of marital relationships lacks a dyadic perspective for understanding how spouses influence the relationship between childhood emotional insecurity and adulthood marital conflict.MethodThe actor–partner interdependence model was employed to test spillover and crossover effects using data from 210 South Korean couples with children age 3–5 years.ResultsChildhood emotional insecurity was associated with marital conflict in both women and men. Additionally, this relationship was mediated by lower levels of self‐esteem. However, the mediating effect was stronger for women than for men. Furthermore, women experiencing emotional insecurity during childhood positively affected their spouses' destructive marital conflict coping strategies through lower self‐esteem, whereas men's childhood emotional insecurity did not affect their spouses' destructive marital conflict through self‐esteem.ConclusionThis study provides strong evidence to explain the mechanism of intergenerational transmission in marital conflicts.ImplicationsFuture research on intergenerational transmission of marital relationships should consider the influence of the family of origin and the interactions between couples by considering the family as an interdependent dynamic system.
Professionalism and clinical short answer question marking with machine learning
Authors: Lam Antoinette , Lam Lydia , Blacketer Charlotte , Parnis Roger , Franke Kyle , Wagner Morganne , Wang David , Tan Yiran , Oakden‐Rayner Lauren , Gallagher Steve , Perry Seth W. , Licinio Julio , Symonds Ian , Thomas Josephine , Duggan Paul , Bacchi Stephen 
Published: July 2022

AbstractMachine learning may assist in medical student evaluation. This study involved scoring short answer questions administered at three centres. Bidirectional encoder representations from transformers were particularly effective for professionalism question scoring (accuracy ranging from 41.6% to 92.5%). In the scoring of 3‐mark professionalism questions, as compared with clinical questions, machine learning had a lower classification accuracy (P < 0.05). The role of machine learning in medical professionalism evaluation warrants further investigation.
Forming a therapeutic sphere to treat ailments using optimization techniques
Authors: Li Han‐Lin , Shih Chia‐Hui , Hu Chih‐Chien , Yang Chyan 
Published: July 2022

AbstractRecently, National Geographic published a special bookazine titled Nature's Best Remedies. This bookazine reorganized nature's remedies as a therapeutic table for treating ailments. The table provides considerable knowledge but is inconvenient to use. This study converts the therapeutic table into a therapeutic sphere by using optimization techniques. In the therapeutic sphere, similar ailments are clustered together, and remedies related to specified ailments are allocated on the sphere. Two surveys demonstrated that, compared with the therapeutic table, the therapeutic sphere is more convenient to use, more efficient for making queries, and more useful for healthcare as well as more intuitive. The proposed therapeutic sphere system can be accessed at http://140.113.73.198/gbball/examples/medeng2.aspx.
Streptomyces sp. BV410: Interspecies cross-talk for staurosporine production
Authors: Stevanovic Milena , D'Agostino Paul M. , Mojicevic Marija , Gulder Tobias A. M. , Nikodinovic-Runic Jasmina , Vojnovic Sandra 
Published: July 2022

Abstract

Aims
Sequencing and genome analysis of two co-isolated streptomycetes, named BV410-1 and BV410-10, and the effect of their co-cultivation on the staurosporine production.

Methods and Results
Identification of two strains through genome sequencing and their separation using different growth media was conducted. Sequence analysis revealed that the genome of BV410-1 was 9.5 Mb, whilst that of BV410-10 was 7.1 Mb. AntiSMASH analysis identified 28 biosynthetic gene clusters (BGCs) from BV410-1, including that responsible for staurosporine biosynthesis, whilst 20 BGCs were identified from BV410-10. The addition of cell-free supernatant from BV410-10 monoculture to BV410-1 fermentations improved the staurosporine yield from 8.35 mg L−1 up to 15.85 mg L−1, whilst BV410-10 monoculture ethyl acetate extract did not have the same effect. Also, there was no improvement in staurosporine production when artificial mixed cultures were created using three different BV410-1 and BV410-10 spore ratios.

Conclusions
The growth of BV410-10 was inhibited when the two strains were grown together on agar plates. Culture supernatants of BV410-10 showed potential to stimulate staurosporine production in BV410-1, but overall co-cultivation attempts did not restore the previously reported yield of staurosporine produced by the original mixed isolate.

Significance and Impact of Study
This work confirmed complex relations between streptomycetes in soil that are difficult to recreate under the laboratory conditions. Also, mining of streptomycetes genomes that mainly produce known bioactive compounds could still be the fruitful approach in search for novel bioactive molecules.