bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Levetiracetam on Ocular Perfusion Measure with OCT-Angiography
Authors: Kaderli Ahmet , Kayılıoğlu Hülya , Kaderli Sema Tamer , Karalezli Aylin 
Published: May 2022

Abstract
Purpose: The aim of the study was to evaluate the macular and optic nerve head blood flow in pediatric epilepsy patients treated with levetiracetam for at least 12 months with optical coherence tomography-angiography (OCTA).Methods: 33 pediatric epilepsy patients and 30 sex and age-matched healthy volunteer children were included in the study. OCTA was used to evaluate the optic nerve head and macular perfusion chages. Mean ocular perfusion pressures (MOPP) were also calculated. Patients using multiple antiepileptic drugs or prior history of different drug use were exluded from the study.Results: Choriocapillaris flow area was significantly lower in the study group than the control group (p=0.006). However, foveal avascular zone, vessel densities of macula in superficial, deep capillary plexus and optic nerve head were not significantly different from healty eyes (p>0.05). There was also no significant difference between the two groups in means of MOPP (p=0.211). No obvious correlation is found between treatment duration and OCTA parameters or MOPP. None of the patients had diplopia, nystagmus, blurred vision, color vision deficiency or increased intraocular pressure.Conclusions: In children taking levetiracetam for at least 12 months, choroidal perfusion was reduced compared to controls, while retinal perfusion was not affected in this OCTA study.
[18F]FDG PET signal correlates with markers of neo-angiogenesis in patients with fibrotic interstitial lung disease who underwent lung biopsy: Implication for the use of PET/CT in diffuse lung diseases
Authors: Porter Joanna C , Ganeshan Balaji , Win Thida , Fraioli Francesco , Khan Saif , Rodriguez-Justo Manuel , Endozo Raymond , Shortman Robert I , Maher Toby M , Groves Ashley M 
Published: May 2022

Abstract
Purpose
The potential to use FDG PET/CT in diffuse lung diseases is becoming increasingly recognised. To understand the potential of the technique better, we investigated the correlation between [18F]FDG lung uptake with microvessel density (MVD) on lung biopsy of patients with fibrotic interstitial lung disease (fILD).
Methods
We recruited 18 patients with fILD who underwent [18F]FDG PET before lung biopsy. We derived target-to-background ratio (TBR) of maximum pulmonary uptake of FDG (SUVmax) divided by the lung background (SUVmin). Consecutive paraffin-embedded sections obtained from biopsy were immunostained for alveolar and interstitial macrophages (CD68), microvessel density (MVD; CD31 and CD105/ endoglin) and glucose transporter 1 (GLUT-1). MVD was expressed as vessel area % per high-power field (Va%/hpf); Statistical analysis was carried out using SPSS.
Results
18 patients were followed for an average of 41.36 months (range 5.69-132.46 months; median 30.07 months). In all patients, MVD assessed with either CD105 or CD31 quantification on biopsy predicted overall survival. Patients with low CD105-MVD (score of < 12 Va%/hpf) and/or low CD31-MVD (score of < 34 Va%/hpf) had a significantly better prognosis (no deaths during follow-up) than patients with higher scores of CD105-MVD (median survival < 35 months, p = 0.041, n = 13) or CD31-MVD (median survival < 30 months, p = 0.037, n = 13). However, only CD105-MVD showed a significantly positive correlation with [18F]FDG TBR (rs = 0.556, p < 0.05, n = 13). There was no correlation between [18F]FDG uptake and macrophage expression of GLUT-1.
Conclusion
Previous work has used FDG-PET as a biomarker in fILD. Here we highlight a correlation between angiogenesis and FDG TBR, both of which predict mortality in patients with fILD. These data set the scene to investigate the potential role of the vasculature and angiogenesis in fibrosis.
Celiac disease Associated with therapy for lymphoma: case report and review of the literature
Authors: Rajadurai Suvithan , Schiffman Fred Jay 
Published: May 2022

Abstract
BackgroundCeliac disease is an autoimmune enteropathy characterized by a reaction to gluten leading to autoantibodies that have deleterious effects on several organs. Most commonly, celiac disease affects the small bowel causing an inflammatory reaction that leads to villous atrophy and thus malabsorption. While post-chemotherapy side effects are varied and affect several organ systems, one of the more common effects seen in patients is diarrhea. However, in some cases diarrhea is not an isolated event but rather a manifestation of new onset celiac disease. We propose that while celiac disease is a relatively rare condition, there may be an association with chemotherapy.Case PresentationA 66-year-old woman with a history of diffuse large B-cell lymphoma (DLBCL), immune idiopathic thrombocytopenia, and hypothyroidism, developed diarrhea and severe hypokalemia two years after completing a 6 cycle EPOCH-R chemotherapy regimen. EPOCH-R consisted of rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin. Evaluation of the patient showed villous blunting and increased intraepithelial lymphocytes in the small intestine as well as increased levels of anti-TTG antibodies, endomysial IgA antibodies, and gliadin IgG antibodies indicating a diagnosis of celiac disease. The patient had no family history of celiac disease or other enteropathies and outside of a brief case of Clostridium difficile colitis, had not experienced any side effects in the immediate post-chemotherapy period. The patient responded well to a gluten-free diet with resolution of her diarrheal symptoms.ConclusionsCeliac disease developing after completion of chemotherapy for DLBCL is a rare phenomenon with only a few examples found in the medical literature. Although diarrhea is a common side effect of chemotherapy for lymphoma, patients with delayed onset of diarrhea with failure to improve despite conventional management, should be evaluated for celiac disease.
Comparison of cisatracurium dosing based on three weight indices in patients with morbid obesity in laparoscopic bariatric surgery
Authors: Rokhtabnak Faranak , Safari Saeed , Motlagh) Soudabeh (Soodabeh) Djalali Motlagh (Jalali , Yavari Toktam , Pardis Elham 
Published: May 2022

Abstract
Background
Different dosing regimens of cisatracurium have been recommended for patients with morbid obesity. The aim of this study was to compare the onset of action, the sufficiency of neuromuscular blockade (NMB) during infusion, and recovery of the three different dosing scalar of cisatracurium.
Methods
In this clinical trial, 57 patients were randomly divided into three groups to receive a bolus of cisatracurium 0.2 mg/kg, followed by an infusion of 2 µg/kg, to maintain a train-of-four (TOF) count ≤ 2, based on either total body weight (TBW, group TBW), fat-free mass (FFM, group FFM), or ideal body weight (IBW, group IBW).
Results
The time to reach a TOF of zero in the TBW group was comparable with the group FFM but was shorter compared to the group IBW (P = 0.15). The rescue dose during maintenance of anesthesia was not required in group TBW, whereas in group IBW more frequently required compared to group FFM (P = 0.027). The recovery time to TOF count 4, TOF ratio of 50%, 75%, and 100% was longer in the TBW group, though they were comparable between the groups FFM and IBW (P = < 0.001, 0.001, < 0.001, 0.002, respectively). The mean surgical condition score was comparable in the groups TBW and FFM, both higher than the group IBW (P < 0.001and P = 0.02, respectively).
Conclusion
Cisatracurium loading and infusion dosing based on FFM provides an onset of action and surgical field condition comparable to the TBW-based dosing with a shorter recovery time. However, IBW-based dosing of cisatracurium is insufficient for laparoscopic bariatric surgery.
Isolation, characterization, and genome investigation of vB_SenS_TUMS_E4, a polyvalent bacteriophage against Salmonella enteritidis
Authors: Torkashvand Narges , Kamyab Haniyeh , Shahverdi Ahmad Reza , Khoshayand Mohammad Reza , Sepehrizadeh Zargham 
Published: May 2022

Abstract

Background
Salmonellosis is a critical and common infectious malady between people and animals caused by Salmonella bacteria. With the advent of antibiotic resistance, it is essential for new methods to be replaced to prevent and treat infections. Bacteriophages are promising choices.
Methods
In this study, phage vB_SenS_TUMS_E4 against Salmonella enteritidis isolate has been separated from poultry wastewater. Determination of phage characteristics, including plaque formation, imaging with transmission electron microscopy, growth curve, structural proteins profile, host range, and pH and temperature parameters. Also, the Phage genome was extracted, sequenced, and annotated, and by utilizing Average Nucleotide Identity and phylogeny was compared with reference Salmonella phages.
Results
The burst size was large, nearly 287 plaque-forming units per cell (PFU/cell) and elevated stability to many temperatures and pH values. Phage vB_SenS_TUMS_E4 was effective on various clinical and environmental strains of Salmonella but did not affect bacteria of other genera. The morphological analysis indicated that phage vB_SenS_TUMS_E4 belongs to the Siphoviridae family. The genome of vB_SenS_TUMS_E4 is a linear dsDNA molecule of 43,018 bp with a G + C content of 49.7%. It includes 60 protein-coding genes, yet it contains no tRNA genes. Among the 60 detected putative protein-coding genes, just 43 gene products were contained in database searches. No genes associated with antibiotic resistance, virulence factor, and lysogenic were realized in the vB_SenS_TUMS_E4 genome.
Conclusion
The findings indicate that the high lytic potency vB_SenS_TUMS_E4 polyvalent phage is an antibacterial agent for controlling Salmonella in food production, prevention, and Salmonella treatment.
PINO-MBD: Physics-informed Neural Operator for Solving Coupled ODEs in Multi-body Dynamics
Authors: Ding Wenhao , He Qing , Tong Hanghang , Wang Ping 
Published: May 2022

Abstract

In multi-body dynamics, the motion of a complicated physical object is described as a coupled ordinary differential equation system with multiple unknown solutions. Engineers need to constantly adjust the object to meet requirements at the design stage, where a highly efficient solver is needed. The rise of machine learning-based partial differential equation solvers can meet this need. These solvers can be classified into two categories: approximating the solution function (Physics-informed neural network) and learning the solution operator (Neural operator). The recently proposed physics-informed neural operator (PINO) gains advantages from both categories by embedding physics equations into the loss function of a neural operator. Following this state-of-art concept, we propose the physics-informed neural operator for coupled ODEs in multi-body dynamics (PINO-MBD), which learns the mapping between parameter spaces and solution spaces. Once PINO-MBD is trained, only one forward pass of the network is required to obtain the solutions for a new instance with different parameters. To handle the difficulty that coupled ODEs contain multiple solutions (instead of only one in normal PDE problems), two new physics embedding methods are also proposed. The experimental results on classic vehicle-track coupled dynamics problem show state-of-art performance not only on solutions but also the first and second derivatives of solutions.
Numerical simulation of the elastic-ideal plastic material behavior of short fiber-reinforced composites including its spatial distribution with an experimental validation
Authors: Rauter Natalie 
Published: May 2022

Abstract

For the numerical simulation of components made of short fiber-reinforced composites the correct prediction of the deformation including the elastic and plastic behavior and its spatial distribution is essential. When using purely deterministic modeling approaches the information of the probabilistic microstructure is not included in the simulation process. One possible approach for the integration of stochastic information is the use of random fields. In this study numerical simulations of tensile test specimens are conducted utilizing a finite deformation elastic-ideal plastic material model. A selection of the material parameters covering the elastic and plastic domain are represented by cross-correlated second-order Gaussian random fields to incorporate the probabilistic nature of the material parameters. To validate the modeling approach tensile tests until failure are carried out experimentally, that confirm the assumption of spatially distributed material behavior in both the elastic and plastic domain. Since the correlation lengths of the random fields cannot be determined by pure analytic treatments, additionally numerical simulations are performed for different values of the correlation length. The numerical simulations endorse the influence of the correlation length on the overall behavior. For a correlation length of 5mm a good conformity with the experimental results is obtained. Therefore, it is concluded, that the presented modeling approach is suitable to predict the elastic and plastic deformation of a set of tensile test specimens made of short fiber-reinforced composite sufficiently.
Hydrodynamic and microbiological characterisation of free ground water in the city of Bafoussam, (West Cameroon)
Authors: Nguedia Djatsa Kevin , Ndongo Barthelémy , Ntankouo Njila Roger , Kagou Dongmo Armand 
Published: May 2022

Abstract
The work presented here aims to carry out a physical characterisation of soils to understand their hydrodynamic behaviour and estimate the susceptibility of each group of soils to microbiological pollution. The field work associated with the laboratory work consisted of monitoring the hydrodynamic behaviour of previously identified and selected well waters, measuring the permeabilities of the soil samples and analysing the bacteriological parameters of the sampled well waters. At the end of this work, the piezometric data show a dominant SE-NW and ENE-OSW flow direction. The water levels vary significantly between the wet and dry seasons. The granulometric analysis of the soils reveals CU&gt;3 showing a spread out granulometry with very low permeabilities of the order of 1.58×10−7 m/s and moderately high permeabilities of the order of 1.86×10−5 m/s. The microbiological data show pollution of human origin with a high bacterial load in the rainy season represented by a maximum of 240 CFU of Escherichia coli exceeding the WHO standards for drinking water. The majority of the polluted samples come from soils developed on granites and basalts, which are the most susceptible to pollution, making the groundwater vulnerable.
Adsorption of Congo red by fibrous xonotlite prepared from waste silicon residue
Authors: Han Mingyu , Shen Xiaoyi , Shao Hongmei , Wang Xinyue , Liu Yan , Zhai Yuchun 
Published: May 2022

Abstract
Fibrous xonotlite was synthesized under the conditions of Na2SiO3 concentration of 0.05 mol·L−1, molar ratio of Si/Ca of 1:1, temperature of 220 °C and time of 9 h. It is worth pointing out that the Na2SiO3 solution as raw material was obtained from silicon residue through several procedures. The fibrous xonotlite exhibits excellent adsorption capacity for Congo red. 50 mL solution of Congo red with the concentrations of 100, 150 and 200 mg·L−1 can be almost completely adsorbed by 30 mg of fibrous xonotlite within 10 min, and the adsorption ratios are 94.05%, 95.50% and 94.14%. The Langmuir model describes the adsorption well, indicating the adsorption is monolayer. The adsorption kinetics follows the pseudo-second-order model. The calculated maximum adsorption capacity of fibrous xonotlite for Congo red is 574.71 mg·g−1 at room temperature. Fibrous xonotlite is a potential efficient adsorbent for Congo red owing to its rapid adsorption, high adsorption capacity and regeneration capacity.
Effective fluorine removal using mixed matrix membrane based on polysulfone: adsorption performance and diffusion behavior
Authors: Zhang Xinbo , Sui Guoyi , Wang Zhe , Ngo Huu Hao , Guo Wenshan , Wen Haitao , Zhang Dan , Wang Xiao , Zhang Jianqing 
Published: May 2022

Abstract
Fluorine is one of the essential trace elements for human life activities, but excessive intake of fluoride poses a great risk to people's health. In this paper, a series of mixed matrix membrane (MMM)-based polysulfone for removing fluoride were prepared by phase inversion, and their properties, adsorption capacity, adsorption isotherms, adsorption kinetics of fluoride ions, and mechanism were all investigated. The results confirmed that the MMM contained a large number of hydroxyl and aluminum functional groups due to resin being added. The MMM exhibited the best fluorine ion adsorption capacity of 2.502 mg/g at a pH of 6 with the initial concentration of 6 mg/L. As well, adsorption kinetics of fluorine ion on MMM followed the pseudo-second-order model, while the adsorption behavior of fluorine ion on MMM was well simulated by the Langmuir isotherm model. The adsorption capacity of MMM remained stable after six cycles and the regeneration efficiency was still above 80%, resulting in a long-term stability adequate for fluorine ion removal. Complexation and ion exchange played a key role in the fluorine ion adsorption of MMM. These results indicated the MMM as novel type of absorbent had an excellent capacity for removing fluoride.
Removal of estrogen pollutants using biochar-pellet-supported nanoscale zero-valent iron
Authors: Deng Peiyuan , Wang Guangzhou , Li Changkan , Dou Shentang , Yuan Wei 
Published: May 2022

Abstract
Nanoscale zero-valent iron-supported biochar pellets (nZVI)-(BP) were synthesized via liquid-phase reduction and applied to estrogen removal, including estrone (E1), 17β-estradiol (E2), and estriol (E3). The performance of nZVI-BP, with respect to its characterization, removal kinetics, and isotherms, was investigated. The results showed that the adsorption equilibrium was reached within 10 min of exposure. The adsorption capacity of estrogen decreased with increasing solute pH and nZVI-BP dosage. The adsorptivity increased with increasing initial estrogen concentration. The estrogen behavior followed a pseudo-second-order kinetic model. The adsorption data of different initial estrogen concentrations fitted to Freundlich adsorption isotherms. In addition, a preliminary discussion of the adsorption mechanism of nZVI-BP for estrogens was provided.
Endovascular Abdominal Aortic Aneurysm Repair With Ovation Alto Stent Graft: Protocol for the ALTAIR (ALTo endogrAft Italian Registry) Study
Authors: de Donato Gianmarco , Pasqui Edoardo , Sirignano Pasqualino , Talarico Francesco , Palasciano Giancarlo , Taurino Maurizio ,   ALTAIR collaborators
Published: May 2022

Background
Since 2010, the Ovation Abdominal Stent Graft System has offered an innovative sealing option for abdominal aortic aneurysm (AAA) by including a sealing ring filled with polymer 13 mm from the renal arteries. In August 2020, the redesigned Ovation Alto, with a sealing ring 6 mm closer to the top of the fabric, received CE Mark approval.

Objective
This registry study aims to evaluate intraoperative, perioperative, and postoperative results in patients treated by the Alto stent graft (Endologix Inc.) for elective AAA repair in a multicentric consecutive experience.

Methods
All consecutive eligible patients submitted to endovascular aneurysm repair (EVAR) by Alto Endovascular AAA implantation will be included in this analysis. Patients will be submitted to EVAR procedures based on their own preferences, anatomical features, and operators experience. An estimated number of 300 patients submitted to EVAR with Alto stent graft should be enrolled. It is estimated that the inclusion period will be 24 months. The follow-up period is set to be 5 years. Full data sets and cross-sectional images of contrast-enhanced computed tomography scan performed before EVAR, at the first postoperative month, at 24 or 36 months, and at 5-year follow-up interval will be reported in the central database for a centralized core laboratory review of morphological changes. The primary endpoint of the study is to evaluate the technical and clinical success of EVAR with the Alto stent graft in short- (90-day), mid- (1-year), and long-term (5-year) follow-up periods. The following secondary endpoints will be also addressed: operative time; intraoperative radiation exposure; contrast medium usage; AAA sac shrinkage at 12-month and 5-year follow-up; any potential role of patients’ baseline characteristics, valuated on preoperative computed tomography angiographic study, and of device configuration (number of component) in the primary endpoint.

Results
The study is currently in the recruitment phase and the final patient is expected to be treated by the end of 2023 and then followed up for 5 years. A total of 300 patients will be recruited. Analyses will focus on primary and secondary endpoints. Updated results will be shared at 1- and 3-5-year follow-ups.

Conclusions
The results from this registry study could validate the safety and effectiveness of the new design of the Ovation Alto Stent Graft. The technical modifications to the endograft could allow for accommodation of a more comprehensive range of anatomies on-label.

Trial Registration
ClinicalTrials.gov NCT05234892; https://clinicaltrials.gov/ct2/show/NCT05234892

International Registered Report Identifier (IRRID)
PRR1-10.2196/36995
Effects of the Population-Based “10,000 Steps Duesseldorf” Intervention for Promoting Physical Activity in Community-Dwelling Adults: Protocol for a Nonrandomized Controlled Trial
Authors: Matos Fialho Paula M , Günther Liane , Schmitz Elena , Trümmler Jannis , Willemsen Sorina , Vomhof Markus , Icks Andrea , Lang Alexander , Kuss Oliver , Weyers Simone , Pischke Claudia R 
Published: May 2022

Background
The World Health Organization recommends 150 minutes of moderate to vigorous physical activity (PA), which translates to approximately 7000 to 10,000 steps per day for adults. In Germany, less than half of the population in this age range meets this recommendation, highlighting the need for population-based intervention approaches for promoting daily PA.

Objective
The complex community-based PA intervention “10,000 Steps Ghent,” which was originally developed in Belgium and was shown to be effective for PA promotion, has been adapted for implementation and evaluation in 2 German cities. The original Belgian study is currently being replicated, and we aim to examine the effectiveness of the adapted intervention among adults living in intervention city districts in Duesseldorf when compared with those living in control city districts in Wuppertal, over the course of 1 year.

Methods
A controlled intervention trial examining the effects of an intervention addressing multiple levels (eg, individual level: website; organizational level: PA promotion in companies; community level: media campaigns and environmental changes) is being conducted. PA and various secondary outcomes will be assessed in 2 random samples of adults aged 25 to 75 years (n=399 in each city) at baseline and after 1 year.

Results
Funding for this study was obtained in March 2020. Recruitment for this study and baseline data collection were conducted from May 2021 to March 2022 (as of March 2022, 626 participants were enrolled in the study). The intervention will be implemented in Duesseldorf for 1 year from April 2022 onward, and follow-up assessments will be conducted, starting in May 2023 (until September 2023). Data analysis will be performed in fall 2023, and the results will be published in spring 2024.

Conclusions
To our knowledge, this is the first research project (currently underway in Germany) that is aimed at replicating the effects of a complex intervention for PA promotion that was previously shown to be effective in another European country.

Trial Registration
German Clinical Trials Register DRKS00024873; https://tinyurl.com/4c9e8azh

International Registered Report Identifier (IRRID)
DERR1-10.2196/39175