bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ophelia, more or less. Intersemiotic reinterpretations of a Shakespearean character
Authors: Percec Dana , Pungă Loredana 
Published: October 2022

Abstract
Ophelia, Shakespeare’s most tragic heroine, seems to be the character who has generated much more enthusiasm on the part of visual artists than on the part of literary critics. Consequently, there are a high number of artefacts, produced starting with the nineteenth century, which have been inspired by Hamlet’s unfortunate bride. Of this assortment of artefacts, we have picked some to deal with here. In analysing them, we survey through the history of the heroine’s representation in various visual media, comment on them from the point of view of intersemiotic translation, and verify, in broad lines, the hypothesis that they may be tributary to a number of factors ranging from some connected to the artist’s own identity and subjective interpretation of the original to factors connected to more general stereotypes, beliefs, attitudes, and socio-cultural trends.
pwrBRIDGE: a user-friendly web application for power and sample size estimation in batch-confounded microarray studies with dependent samples
Authors: Xia Qing , Thompson Jeffrey A. , Koestler Devin C. 
Published: October 2022

Abstract

Batch effect Reduction of mIcroarray data with Dependent samples usinG
Empirical Bayes (BRIDGE) is a recently developed statistical method to address the issue of batch effect correction in batch-confounded microarray studies with dependent samples. The key component of the BRIDGE methodology is the use of samples run as technical replicates in two or more batches, “bridging samples”, to inform batch effect correction/attenuation. While previously published results indicate a relationship between the number of bridging samples, M, and the statistical power of downstream statistical testing on the batch-corrected data, there is of yet no formal statistical framework or user-friendly software, for estimating M to achieve a specific statistical power for hypothesis tests conducted on the batch-corrected data. To fill this gap, we developed pwrBRIDGE, a simulation-based approach to estimate the bridging sample size, M, in batch-confounded longitudinal microarray studies. To illustrate the use of pwrBRIDGE, we consider a hypothetical, longitudinal batch-confounded study whose goal is to identify Alzheimer’s disease (AD) progression-associated genes from amnestic mild cognitive impairment (aMCI) to AD in human blood after a 5-year follow-up. pwrBRIDGE helps researchers design and plan batch-confounded microarray studies with dependent samples to avoid over- or under-powered studies.
Protection against H2O2-evoked toxicity in HT22 hippocampal neuronal cells by geissoschizine methyl ether via inhibiting ERK pathway
Authors: Hu Shengquan , Yang Lei , Ma Yucui , Li Limin , Li Zhiyue , Wen Xiaomin , Wu Zhengzhi 
Published: October 2022

Abstract
Oxidative stress is considered as an important mechanism underlying the pathology of neurodegenerative disorders. In this study, we utilized an in vitro model where oxidative stress process was evoked by exogenous hydrogen peroxide (H2O2) in HT22 murine hippocampal neurons and evaluated the neuroprotective effects of geissoschizine methyl ether (GME), a naturally occurring alkaloid from the hooks of Uncaria rhynchophylla (Miq.) Jacks. After a 24 h H2O2 (350 μM) insult, a significant decrease in cell survival and a sharp increase in intracellular reactive oxygen species were observed in HT22 cells. Encouragingly, GME (10–200 μM) effectively reversed these abnormal cellular changes induced by H2O2. Moreover, mechanistic studies using Western blot revealed that GME inhibited the increase of phospho-ERK protein expression, but not phospho-p38, caused by H2O2. Molecular docking simulation further revealed a possible binding mode that GME inhibited ERK protein, showing that GME favorably bound to ERK via multiple hydrophobic and hydrogen bond interactions. These findings indicate that GME provide effective neuroprotection via inhibiting ERK pathway and also encourage further ex vivo and in vivo pharmacological investigations of GME in treating oxidative stress-mediated neurological disorders.
Loss of ribonuclease DIS3 hampers genome integrity in myeloma by disrupting DNA:RNA hybrid metabolism
Authors: Gritti Ilaria , Basso Veronica , Rinchai Darawan , Corigliano Federica , Pivetti Silvia , Gaviraghi Marco , Rosano Dalia , Mazza Davide , Barozzi Sara , Roncador Marco , Parmigiani Giovanni , Legube Gaelle , Parazzoli Dario , Cittaro Davide , Bedognetti Davide , Mondino Anna , Segalla Simona , Tonon Giovanni 
Published: October 2022

AbstractThe ribonuclease DIS3 is one of the most frequently mutated genes in the hematological cancer multiple myeloma, yet the basis of its tumor suppressor function in this disease remains unclear. Herein, exploiting the TCGA dataset, we found that DIS3 plays a prominent role in the DNA damage response. DIS3 inactivation causes genomic instability by increasing mutational load, and a pervasive accumulation of DNA:RNA hybrids that induces genomic DNA double‐strand breaks (DSBs). DNA:RNA hybrid accumulation also prevents binding of the homologous recombination (HR) machinery to double‐strand breaks, hampering DSB repair. DIS3‐inactivated cells become sensitive to PARP inhibitors, suggestive of a defect in homologous recombination repair. Accordingly, multiple myeloma patient cells mutated for DIS3 harbor an increased mutational burden and a pervasive overexpression of pro‐inflammatory interferon, correlating with the accumulation of DNA:RNA hybrids. We propose DIS3 loss in myeloma to be a driving force for tumorigenesis via DNA:RNA hybrid‐dependent enhanced genome instability and increased mutational rate. At the same time, DIS3 loss represents a liability that might be therapeutically exploited in patients whose cancer cells harbor DIS3 mutations.
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Authors: Simon Matthew , Yang Jiping , Gigas Jonathan , Earley Eric J , Hillpot Eric , Zhang Lei , Zagorulya Maria , Tombline Greg , Gilbert Michael , Yuen Samantha L , Pope Alexis , Van Meter Michael , Emmrich Stephan , Firsanov Denis , Athreya Advait , Biashad Seyed Ali , Han Jeehae , Ryu Seungjin , Tare Archana , Zhu Yizhou , Hudgins Adam , Atzmon Gil , Barzilai Nir , Wolfe Aaron , Moody Kelsey , Garcia Benjamin A , Thomas David D , Robbins Paul D , Vijg Jan , Seluanov Andrei , Suh Yousin , Gorbunova Vera 
Published: October 2022

AbstractSirtuin 6 (SIRT6) is a deacylase and mono‐ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in aging and metabolism regulation. Targeted sequencing of SIRT6 locus in a population of 450 Ashkenazi Jewish (AJ) centenarians and 550 AJ individuals without a family history of exceptional longevity identified enrichment of a SIRT6 allele containing two linked substitutions (N308K/A313S) in centenarians compared with AJ control individuals. Characterization of this SIRT6 allele (centSIRT6) demonstrated it to be a stronger suppressor of LINE1 retrotransposons, confer enhanced stimulation of DNA double‐strand break repair, and more robustly kill cancer cells compared with wild‐type SIRT6. Surprisingly, centSIRT6 displayed weaker deacetylase activity, but stronger mADPr activity, over a range of NAD+ concentrations and substrates. Additionally, centSIRT6 displayed a stronger interaction with Lamin A/C (LMNA), which was correlated with enhanced ribosylation of LMNA. Our results suggest that enhanced SIRT6 function contributes to human longevity by improving genome maintenance via increased mADPr activity and enhanced interaction with LMNA.
Erythropoietin signaling in peripheral macrophages is required for systemic β‐amyloid clearance
Authors: Xu Lu , Li Lei , Pan Cai‐Long , Song Jing‐Jing , Zhang Chen‐Yang , Wu Xiang‐Hui , Hu Fan , Liu Xue , Zhang Zhiren , Zhang Zhi‐Yuan 
Published: October 2022

AbstractImpaired clearance of beta‐amyloid (Aβ) is a primary cause of sporadic Alzheimer's disease (AD). Aβ clearance in the periphery contributes to reducing brain Aβ levels and preventing Alzheimer's disease pathogenesis. We show here that erythropoietin (EPO) increases phagocytic activity, levels of Aβ‐degrading enzymes, and Aβ clearance in peripheral macrophages via PPARγ. Erythropoietin is also shown to suppress Aβ‐induced inflammatory responses. Deletion of EPO receptor in peripheral macrophages leads to increased peripheral and brain Aβ levels and exacerbates Alzheimer's‐associated brain pathologies and behavioral deficits in AD‐model mice. Moreover, erythropoietin signaling is impaired in peripheral macrophages of old AD‐model mice. Exogenous erythropoietin normalizes impaired EPO signaling and dysregulated functions of peripheral macrophages in old AD‐model mice, promotes systemic Aβ clearance, and alleviates disease progression. Erythropoietin treatment may represent a potential therapeutic approach for Alzheimer's disease.
Pemanfaatan Media E-Learning Berbasis Jejaring Sosial Facebook Sebagai Sarana Pembelajaran Geografi di SMA Kota Semarang
Authors: Nugraha Asep Pujasari , Juhadi Juhadi , Santoso Apik Budi 
Published: October 2022

Dalam pendidikan adanya internet memunculkan gagasan adanya distance learning atau pembelajaran jarak jauh, hal ini di karenakan adanya keterbatasan dalam pembelajaran di kelas dan kondisi pembelajaran sekarang yang membutuhkan pembelajaran yang fleksible dalam waktu dan tempat lingkungan hidup agar siswa dapat berpartisipasi secara langsung. Permasalahan yang ditemukan di sekolah adalah belum optimal penyerapan materi geografi oleh siswa, pemanfaatan fasilitas wifi dan Facebook di sekolah, sehingga dilakukan penelitian produk media e learning Facebook. Penelitian ini merupakan penelitian pengembangan yang bertujuan: 1) Mendesain media e-learning Facebook pada pembelajaran geografi, 2) Mengetahui kualitas hasil media e-learning Facebook menurut review ahli, dan uji coba siswa, 3) Mengetahui kelayakan media e-learning Facebook pada pembelajaran geografi. Desain e-learning Facebook diproduksi dengan merancang flowchart dan storyboard sebagai dasar merancang produk e-learning Facebok. Efektivitas e-learning Facebook dilakukan oleh siswa kelas x dari 6 sekolah yang ada di SMA kota semarang. Jenis penelitian menggunakan pre-experimen designs (ekperimen tidak sebenarnya). Teknik pengumpulan data menggunkan dokumentasi, angket kuesioner.
PENGARUH TINGKAT PENDIDIKAN WISATAWAN TERHADAP PERILAKU PEDULI LINGKUNGAN DI OBJEK WISATA WADUK CENGKLIK KABUPATEN BOYOLALI
Authors: Rakhmatin Wuri Daningtias , Sholeh Muh 
Published: October 2022

Tujuan dari dilakukanya penelitian ini adalah untuk mengetahui tingkat pendidikan wisatawan di obejk wisata Waduk Cengklik, mengetahui perilaku peduli lingkungan wisatawan, menganalisis pengaruh tingkat pendidikan wisatawan terhadap perilaku peduli lingkungan di objek wisata Waduk Cengklik Kabupaten Boyolali. Penelitian ini merupakan penelitian kuantitati. Populasi dalam penelitian ini semua wisatawan yang berkunjung di objek wisata Waduk Cengklik.Sampel pada penelitian ini sebanyak 100 wisatawan dengan menggunakan teknik sampling insindental sampling. Teknik analisis data dengan menggunakan deskriptif persentase dan regresi linier sederhana. Hasil penelitian menunjukan bahwa tingkat pendidikan wisatawan kebanyakan berasal dari lulusan SMA/Sederajat dengan jumlah 42 responden atau 42 %. Hasil perilaku peduli lingkungan berdasarkan tingkat pendidikan SD/Sederajat memiliki rata-rata 62% dengan kriteria cukup, SMP/Sederajat memiliki rata-rata 77% dengan kriteria baik. SMA/Sederajat memiliki rata-rata 81% dengan kriteria baik, sedangkan perguruan tinggi memiliki rata-rata 88% dengan kriteria sangat baik. Pengaruh tingkat pendidikan wisatawan terhadap perilaku peduli lingkungan setelah dilakukan uji regresi linier sederhana memperoleh persamaan Y= 59.905 + 7,132 X. Terdapat pengaruh tingkat pendidikan wisatawan terhadap perilaku peduli lingkungan di objek wisata sebesar 59,7 %.
Movie Review "The Rainmaker (1997)" Produced by American Zoetrop Constellations Films
Authors: Fadhillah Mutia Siti 
Published: October 2022

The Rainmaker is a 1997 American legal drama film based on John Grisham's 1995 novel of the same name, and written and directed by Francis Ford Coppola. It stars Matt Damon, Danny DeVito, Danny Glover, Claire Danes, Jon Voight, Roy Scheider,Mickey Rourke, Virginia Madsen, Mary Kay Place and Teresa Wright in her final film role. Differences from the novel. The film follows the book in most details, but changes the order of events: in the book, the confrontation ending with Rudy's self-defense killing of Kelly's abusive husband occurs after the end of the trial, not during. Also, the film leaves out an important piece of information from the book that was a central point of Rudy's case: the fact that the leukemia victim had an identical twin, which would have made a transplant virtually certain to work as it would have been a perfect genetic match.
Copacabana is more than a beach in Rio de Janeiro, Brazil: the orchid flora of Parque Estadual da Chacrinha
Authors: Barberena Felipe Fajardo Villela Antolin , Da Silva Roberto , Lopes Rosana Conrado 
Published: October 2022

Orchidaceae is the most diverse botanical family in the city of Rio de Janeiro, Brazil, with 79 genera and 250 species. Vegetation in Rio de Janeiro is mostly restricted to small fragments of Atlantic Forest, many of which are located within conservation units and act as refuges for flora. Some of the best-known postcards of the city, such as Corcovado and Sugar Loaf mountains, and the Christ the Redeemer statue, are located within rban conservation units. This work presents the results of a floristic-taxonomic study of Orchidaceae in the Parque Estadual da Chacrinha (PE Chacrinha), a state park located extremely near the famous Copacabana beach in the heart of Rio de Janeiro. Brief morphological descriptions of the species are provided and an identification key for the orchids of PE Chacrinha is presented, based mainly on vegetative morphological characters. Orchidaceae of PE Chacrinha is represented by thirteen genera and 16 species, most of which restricted to Brazil, seven of them are also endemic to the Atlantic Forest, or South America and occur as terricolous or rupicolous. We highlighted the occurrences of Acianthera limae, Epidendrum ammophilum and Prescottia spiranthophylla, species that grow exclusively or predominantly on rocky outcrops. With these findings, our goal is to raise awareness among the local population about the importance of conserving the regional flora; estimulate visits to PE Chacrinha and promote the inclusion of this conservation unit in the tourist tinerary of the city of Rio de Janeiro.
UHPLC–Q/Orbitrap/MS/MS fingerprinting of Bai-Hu-Jia-Ren-Shen-Tang Decoction and evaluation of its antioxidant activity in streptozotocin-induced diabetic rats
Authors: Wang Libin , Shen Xin , Wang Fang , Xu Xiaohui 
Published: October 2022

AbstractBai-Hu-Jia-Ren-Shen-Tang Decoction (BHJRSTD) is one of the oldest classic Chinese medicine prescriptions which used in the field of treatment of diabetes. However, to the best of our knowledge, the ingredients of this prescription have not been identified, and there are very few studies on the anti-diabetic mechanism of this prescription. Therefore, BHJRSTD was detected and identified by ultra-high-performance liquid chromatography coupled with Quadrupole-Exactive Focus Orbitrap MS (UHPLC–Q/Orbitrap/MS/MS). We identified 74 compounds, including flavonoids, alkaloids, chalcones, xanthones, phenols, phenylpropanoids, terpenes, triterpenes, amino acid derivatives, etc. Then, Sprague Dawley rats were fed with a high-fat and high-sugar diet for two months and injected with streptozotocin (STZ) to induce type 2 diabetes (T2DM). The diabetic rats were randomized to given metformin (200 mg kg−1·d−1, n = 15), BHJRSTD extracts (40 g kg−1·d−1) and BHJRSTD extracts (10 g kg−1·d−1) by gavage for 8 weeks. The results confirmed that BHJRSTD significantly decreased the level of MDA and increased levels of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), it shows that the prescription has significant antioxidant activity in the treatment of T2DM.
Cine y sociedad en David Puttnam
Authors: Pardo Alejandro 
Published: October 2022

Este trabajo trata sobre las relaciones cine y sociedad según las entiende el cineasta británico, David Puttnam, productor de películas tales como Carros de Fuego, Los gritos del silencio y La misión. Además de ser un productor creativo, lo que diferencia a Puttnam de otros productores es su comprensión del cine como un medio de comunicación de masas. En este sentido, Puttnam argumenta que las películas tienen una poderosa influencia en la sociedad, y que por lo tanto el cineasta debe ser responsable de su responsabilidad social./
This article deals with the relationships between cinema and society, according to the British filmmaker David Puttnam, producer of movies such as CHARIOTS OF FIRE, THE KIILING FIELDS and THE MISSION. Besides being a creative producer, what differences Puttnam from other film producers is his understanding of movies as mass communication. In this sense, Puttnam argues that movies have a powerful influence on society, and therefore filmmakers must be aware of their social responsibility.
La resignificación de la ley moral natural en el pensamiento medieval
Authors: Filippi Silvana 
Published: October 2022

The notion of natural law was to a great extent discovered by the
Greeks. Although formulated for the first time by the Stoics, there
are important precedents in previous philosophers and tragic writers.
Nevertheless, the coming of Christianity, by virtue of its concept
of creation, brought along a different notion of God and nature.
This meant a decisive change in the notion of the natural law,
which we will highlight in these pages.
Las voces de «El Criticón». Ensayo de traducción al italiano de «Honores y horrores de Vejecia» (III, 1)
Authors: Garzelli Beatrice 
Published: October 2022

La elección de El Criticón de Baltasar Gracián en esta ocasión se debe ante todo al hecho de que fue la obra maestra que estudié bajo la guía de Alessandro Martinengo, mi director de tesis en la Universidad de Pisa, entre 1994 y 1995. Como en un círculo que se abre y se cierra a distancia de más de 25 años, presento en este artículo una reflexión sobre la novela graciana desde una óptica traductológica gracias al primer proyecto de traducción al italiano de toda la producción del jesuita aragonés (editorial Bompiani), en el cual participo con un pequeño grupo de investigadores italianos.
Partiendo del perspectivismo que en El Criticón alcanza su valor máximo gracias al punto de vista contrario de Critilo y Andrenio —los dos peregrinos de la vida, protagonistas del viaje novelesco— se pone el acento sobre la dificultad de trasladar al italiano contemporáneo un lenguaje múltiple, dilógico y antitético, salvaguardando asimismo el estilo concentrado y lacónico del autor, así como la intensificación máxima del conceptismo del cual Gracián resulta contemporáneamente teorizador y usuario. La crisi que elegimos (Honores y horrores de Vejecia), la primera de la tercera parte de la novela, nos permite también hacer un cotejo con las únicas dos traducciones al italiano preexistentes (una primera, barroca, que firma Cattaneo en 1685 y la segunda de Serpentini, publicada en 2008), elaborando a veces soluciones alternativas de traducción, posiblemente más respetuosas y coherentes con respecto al prototexto graciano.
Comparison of Histopathological Characteristics of Laryngeal Squamous Cell Carcinoma in Turkish and Syrian Patient Populations
Authors: GÜRSOY Didar , SEÇİNTİ İlke Evrim , DORAN Yusuf , DOĞAN Esin , OKUYUCU Şemsettin 
Published: October 2022

Objectives: This study aimed to identify the differences between the tumors and their histopathological characteristics in the materials obtained by laryngectomy performed because of laryngeal squamous cell carcinoma (LSCC) in Turkish and Syrian patient populations.
Material and Method: Our study has a retrospective design. The present study included all the patients who were diagnosed with squamous cell carcinoma between January 2010 to January 2021 and underwent laryngectomy in our institute. Medical records, pathology and radiology reports were reviewed. Demographic and histopathological factors were statistically compared between Turkish and Syrian groups.
Results: Of 93 cases included in our study, 53 (57%) were Syrian while 40 (43%) were Turkish citizens. We have determined no statistically significant difference between two patient groups.
Conclusions: Hatay is a geography that Syrians were familiar with its culture before the war and both societies are exposed to the same environmental conditions. Therefore, we might have found no significant difference between the demographic and histopathological characteristics of laryngeal cancer in Turkish and Syrian patient populations.
Role of Hematological Parameters in Systemic Sclerosis Patients with Pulmonary System Involvement
Authors: TEZCAN Dilek , TURAN Çağrı , HAKBİLEN Selda , YİLMAZ Sema 
Published: October 2022

Aim: Systemic sclerosis (SSc) is an autoimmune disease characterized by generalized micro and macroangiopathy. Mortality in SSc is primarily due to pulmonary complications. This study was aimed to reveal the relationship between parenchymal and vascular involvements of the pulmonary system and hematological parameters in patients with SSc.
Material and Method: Participants were divided into three groups: both interstitial lung disease (ILD) and pulmonary hypertension (PH), those with only ILD and those with neither ILD nor PH. Laboratory data were compared between these groups.
Results: ILD was found to be associated with high red cell distribution width (RDW) and erythrocyte sedimentation rate, independent of PH. The platelet (PLT) count was significantly lower, and the RDW to PLT ratio (RPR) level was significantly higher in those with ILD and PH coexistence compared to those with only ILD.
Conclusion: RPR can be used as screening parameters for PH in ILD associated with SSc.
Fluid Accumulation Dilemma in the Critically Ill Children, A Retrospective Study
Authors: UYAR Emel , GÜNGÖR Ahmet Alptuğ , PERK Oktay , ÖZCAN Serhan , KOÇKUZU Esra , EMEKSİZ Serhat 
Published: October 2022

Aim: Fluid accumulation occurs in pediatric patients in pediatric intensive care units (PICU). Medications administered in pediatric intensive care units can contribute to significant cumulative load in patients. In present study, we aimed to study fluid accumulation on patients without AKI and to determine contribution of medications over fluid intake.
Material and Method: In this study, 527 daily follow-up forms of 101 patients was investigated retrospectively.
Results: Total fluid load was found to be higher in patients with comorbidities, who underwent invasive mechanical ventilation, and who needed inotropes. While fluid load was higher in patients with sepsis than in other diagnostic groups, it was significantly lower in patients with multisystem inflammatory syndrome in children (MIS-C). While the median (IQR) of the cumulative fluid load was 11.6% (7.1-16.4) in the first 5 days, the median (IQR) reached 25.7% (14.65-34.1) on the 10th day. The cumulative fluid load increased as the patient's follow-up days increased. The median average daily fluid intake (IQR) from drugs alone was 14.48% (8.07-24.13). The contribution of drugs to the total fluid load increased as the age of patients decreased (r: -0.164, p< 0.001).
Conclusion: A cumulative fluid load occurs in PICU patients without AKI. Particularly in young children, the contribution of fluids given with drugs to the fluid load should be kept in mind. Clinicians should perform patient-specific fluid management by supporting fluid status assessments with objective criteria in order to get out of the fluid accumulation- fluid over load dilemma.