bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness analysis of gender transition medical interventions in Sweden
Authors: Kirey-Sitnikova Yana , Ahmed Sayem 
Published: March 2022

Abstract
Purpose: Insurance coverage of gender transition medical interventions (GTMI), including hormone-replacement therapy and sex-reassignment surgeries, is a contested topic around the globe. However, a limited number of studies performed a cost-effectiveness analysis (CEA), necessitating more research in this area.Methods: Following a systematic review, two epidemiological studies — one for trans women (vaginoplasty) in Sweden, another for trans men (mastectomy and hysterectomy) in Iran — were identified as suitable for CEA. Improvement in health-related quality of life (HRQoL), demonstrated in these studies, was used to calculate quality-adjusted life years (QALY). Costs for the Swedish healthcare system were taken from literature. A simple decision tree model and sensitivity analysis with Monte Carlo simulation were used to determine cost-effectiveness.Results: Surgeries for trans men were found to be cost-effective in a Swedish healthcare perspective, while surgeries for trans women were on the verge of being not cost-effective. The lack of accurate data made it impossible to calculate indirect effects of surgeries on outcomes such as risk of HIV, depression, drug abuse, and suicide attempts.Conclusion: The present study demonstrates a significant gap in the epidemiological research on GTMI and suggests directions for improvement.
Dual-targeting micelles with ROS-sensitive H2S donor based on Sialic acid and Chondroitin sulfate for atherosclerosis
Authors: Chen Daquan , Chen Qiang , Guo Chunjing , Zhou Xiudi , Su Yanguo , Guo Huimin , Cao Min , Li Jing , Zhang Yue , Zhao Weiyi , Gao Xin , Mi Shuqi 
Published: March 2022

Abstract
Background: Currently, very limited therapeutic approaches are available for the drug treatment of atherosclerosis(AS). H2S-donor is becoming a common trend in much life-threatening research. Several studies have documented that H2S-lyase is predominantly present in endothelial cells. Sialic acid, natural carbohydrate, binds specifically to the E-selectin receptor of endothelial cells. Meanwhile, Recent studies related to Chondroitin sulfate have excellent target binding ability with CD44 receptor. We conjecture that the dual targeting of chondroitin sulfate and Sialic acid not only enhances the accumulation of the drug in the lesion but also cleaves the H2S donor, thus one stone two birds. Methods: Given these findings, we synthesized two kinds of nanoparticles, Carrier I (SCCF) and Carrier II (SCTM), for atherosclerosis to validate our guesses. Initially, S-allyl-L-cysteine and 4-methoxyphenylthiourea were used as H2S donors for SCCF and SCTM, respectively. After the introduction of ROS-sensitive groups. Then, chondroitin sulfate as the modified matrix and Sialic acid as the targeting group, micelles were prepared to load rapamycin(RAP). Results: In the in vitro assay, micelles were significantly different under H2O2 (1 mM) conditions. In the targeting test, the dual-target effect was superior to the other subgroups. treatment with SCCF@RAP and SCTM@RAP effect in AS is remarkable as confirmed via Oil Red O staining. Conclusions: Thus, we conclude that the effect of dual targeting nanomicelles with ROS-sensitive H2S donor will have a better role in atherosclerosis.
BNPs@SiO2(CH2)3 -TAPC-O-(CH2)2NH2-Pd (0) as a Nanocatalyst for the Coupling Reactions and Removing of Organic Dyes
Authors: Khodamorady Minoo , Jafarzadeh Mohammad , Bahrami Kiumars. 
Published: March 2022

Abstract
BNPs@SiO2(CH2)3-TAPC-O-(CH2)2NH2-Pd (0) as a highly sustainable, renewable and effectual heterogeneous nano-catalyst is used for C-C cross coupling reactions and removal of cationic (Methylen Blue) and anionic (Methyl Orange) organic dyes from aqueous medium. This nano-catalyst has features such as high activity, low cost, excellent stability, recoverability for six consecutive times with little loss in catalytic power.
Environmental Policy paradigm shifts in the post-1990 period in India
Authors: SHARMA JAGMOHAN 
Published: March 2022

Abstract
The post-1990 period continues to witness focus on addressing environmental pollution, conservation of biological diversity, restoration of natural ecosystems, and sustainable development. For India, it is further contextualized by the launch of the economic liberalization process in 1991, as it unleashed a severe contestation between economic activity and environmental conservation needs. From the literature, five environmental policy paradigm shifts are apparent in the post-1990 period in India: a) right to a clean environment as a fundamental right; b) polluter accountable for pollution; c) prevention approach to pollution; d) intergenerational considerations in environmental decision-making; and e) consultations-based approach to decision making. Results of the questionnaire-based survey reveal that a predominant majority of experts agrees on the abovementioned policy paradigm shifts. Such agreements range between 68% for ‘intergenerational consideration in decision-making’ to 93% for ‘right to clean environment’. Among the drivers of change, court judgments and civil society groups are the most influential drivers followed by the agency of international conventions, industrial accidents, constitutional amendments, and externally aided projects.
Metabolic Disorders in Long-Living Patients with Coronary Artery Disease
Authors: Topolyanskaya Svetlana , Eliseeva Tatyana A. , Balyasnikova Natalya A. , Sanina Anna I. , Vakulenko Olga N. , Dvoretski Leonid I. 
Published: March 2022

Abstract
Background/Objective Very limited data are available on metabolic disorders in centenarians; therefore, we investigated these pathologies in long-living patients with coronary artery disease (CAD). Methods The study enrolled 225 patients > 90 years, hospitalized with CAD diagnosis. The majority of patients (67.6%) were women. The mean age of patients was 92.5 ( + 2.2) years. Blood levels of uric acid, lipids, glucose and body mass index were determined. Results Obesity was registered in 31.5% of patients, but grade III obesity – in 1 patient. Overweight was found in 39.1% of patients, normal BMI – in 28.9%, and underweight – in 1 patient. Increase in the blood concentration of triglycerides was noted in 11.2% of patients. Decrease in the HDL cholesterol level was registered in 12.7% of patients. Blood concentration of LDL cholesterol < 2.0 mmol / l was observed in 23.3% of cases. Hyperuricemia was detected in 37.3% of patients – in 41.4% of women and 28.8% of men. Increase in the serum creatinine level was registered in 45% of patients. Only 16.5% of patients had glomerular filtration rate > 60 ml/min. Women had more frequent hyperuricemia, dyslipidemia and azotemia. Increase in fasting blood glucose level was found in 23.1% of patients, but only 0.9% of patients had glucose >14 mmol/l. Conclusions Study results indicate some clinical features of metabolic disorders in long-living patients with coronary artery disease. High proportion of patients with overweight or obesity was found. Frequent hyperuricemia but relatively low levels of atherogenic lipids and glucose were registered.
Digital Haptics Improve Speed of Visual Search Performance in a Dual-Task Setting
Authors: Tivadar Ruxandra I. , Arnold Rebecca C. , Turoman Nora , Knebel Jean-François , Murray Micah M. 
Published: March 2022

Abstract
Dashboard-mounted touchscreen tablets are now common in vehicles. Screen/phone use in cars likely shifts drivers’ attention away from the road and contributes to risk of accidents. Nevertheless, vision is subject to multisensory influences from other senses. Haptics may help maintain or even increase visual attention to the road, while still allowing for reliable dashboard control. Here, we provide a proof-of-concept for the effectiveness of digital haptic technologies (hereafter digital haptics), which use ultrasonic vibrations on a tablet screen to render haptic perceptions. Healthy human participants (N = 25) completed a divided-attention paradigm. The primary task was a centrally-presented visual conjunction search task, and the secondary task entailed control of laterally-presented sliders on the tablet. Sliders were vertical, horizontal or circular and were presented visually, haptically, or visuo-haptically. We reasoned that the primary task would be performed best when the secondary task was haptic-only. Reaction times (RTs) on the visual search task were fastest when the tablet task was haptic-only. This was not due to a speed-accuracy trade-off. While precision with the tablet task was lowest when haptic-only, such can likely be readily trained. These results provide the first quantitative support for introducing digital haptics into vehicle and similar contexts.
Is Schistosomiasis a Red Herring in Carcinoma of the Bladder?
Authors: Sanusi Haruna Muhammad , Taoheed Atanda Akinfenwa 
Published: March 2022

Objective: The specific role Schistosoma ova play in bladder carcinogenesis as well as its association with a specific morphologic subtype has remained inconclusive. This study aims to re-evaluate this relationship morphologically and review the literature.
Materials: A 19-year (1999-2017) review of all cases of carcinoma of the bladder with or without schistosomiasis was conducted. This was supplemented with a review of the literature.
Results: 278 cases of carcinoma of the bladder were diagnosed. These comprised 251 males and 27 females in ratio 9:1 and mean ages 56±15 years and 54±16 years respectively (p 0.6). While none of the 27 carcinomas among females had Schistosoma ova 28 of the 251 carcinomas in males were co-morbid with schistosomiasis. These comprised 13 of the 174 TCC, 14 of the 94 SCC, and 1 of the 10 adenocarcinomas. There were no statistically significant differences in gender (p 0.6), age (p 0.6), or co-morbidity with the parasite (p 0.2) among the various histologic subtypes. A review of the literature shows an association of Schistosoma ova not only with SCC but also with TCC and, but for isolated case reports, there is a paucity of definitive association with cancers outside the bladder.
Conclusion: There were no statistically significant differences in gender, age, or co-morbidity with the parasite among the various histologic subtypes. In addition to this, the literature review suggests there must be other co-factors present only in the bladder, rather than just the ova by itself, responsible for Schistosoma-associated carcinoma in this organ.
El Digital Storytelling como herramienta educativa de desarrollo de la creatividad. Un estudio de caso en una cuna jardín peruana
Authors: Hurtado-Mazeyra Alejandra , Afata-Ataucuri Katherine Eudis , Ancasi-Villagomez Gianella Solange , Núñez-Pacheco Rosa 
Published: March 2022

El Digital Storytelling (DST) es una herramienta digital que sirve para desarrollar la creatividad y potenciar las habilidades narrativas en los estudiantes de diferentes niveles educativos. Se realizó una investigación de enfoque cuantitativo de tipo preexperimental en una cuna jardín en Perú con el objetivo central de comprobar la mejora de la creatividad después de la experiencia con la herramienta DST. Participaron 70 niños de 5 y 6 años utilizando la herramienta Sumaq Willakuy (Cuento bonito), un software diseñado para la creación de narrativas digitales para niños de educación infantil. El instrumento aplicado en el estudio es el TCI (Test de creatividad infantil). Los resultados indicaron que existen diferencias significativas entre el pretest y el postest en el puntaje global de la creatividad infantil (PD), especialmente en las variables proceso o producto (PDB) y figuras añadidas (PDC). No se encontraron diferencias significativas en función a la edad y el sexo. Se concluye que el uso del DST ha mejorado la capacidad creativa de los niños. En tal sentido, el DST puede ser aplicada en otros contextos similares para desarrollar la creatividad infantil.
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The Role of Alternative Toxicological Trials in Drug Discovery Programs.
The Case of Caenorhabditis elegans and Other Methods
Authors: Göethel Gabriela , Augsten Lucas Volnei , das Neves Gustavo Machado , Gonçalves Itamar Luís , de Souza João Pedro Silveira , Garcia Solange Cristina , Eifler-Lima Vera Lucia 
Published: March 2022

Abstract:
The discovery of a new drug requires over a billion dollars and around 12
years of research efforts, and toxicity is the leading reason for the failure to approve candidate
drugs. Many alternative methods have been validated to detect toxicity as early as
possible to diminish the waste of resources and efforts in medicinal chemistry research,
and in vivo alternative methods are especially valuable for the amount of information
they can provide at little cost and in a short time. In this work, we present a review of the
literature published between the years 2000 and 2021 on in vivo alternative methods of
toxicity screening employed in medicinal chemistry, which we believe will be useful because,
in addition to shortening the research time, these studies provide much additional
information aside from the toxicity of drug candidate compounds. These in vivo models
include zebrafish, Artemia salina, Galleria mellonella, Drosophila melanogaster, planarians,
and Caenorhabditis elegans. The most published ones in the last decade were zebrafish,
D. melanogaster, and C. elegans due to their reliability, ease, and cost-effectiveness
in implementation and flexibility. Special attention is given to C. elegans because of
its rising popularity, a wide range of uses, including toxicity screening, and active effects
measurement, from antioxidant effects to anthelmintic and antimicrobial activities, and
its fast and reliable results. Over time, C. elegans also became a viable high-throughput
(HTS) automated drug screening option. Additionally, this manuscript lists briefly the
other screening methods used for the initial toxicological analyses and the role of alternative
in vivo methods in these scenarios, classifying them as in silico, in vitro and alternative
in vivo models that have been receiving a growing increase in interest in recent
years.
Advancement and Applications of Platelet-inspired Nanoparticles:
A Paradigm for Cancer Targeting
Authors: Swain Suryakanta , Ghose Debashish , Patra Chinam Niranjan , Jena Bikash Ranjan , Rao Muddana Eswara Bhanoji 
Published: March 2022

Abstract:
Platelet-inspired nanoparticles have ignited the possibility of new opportunities for producing
similar biological particulates, such as structural cellular and vesicular components, as well
as various viral forms, to improve biocompatible features that could improve the nature of biocompatible
elements and enhance therapeutic efficacy. The simplicity and more effortless adaptability of
such biomimetic techniques uplift the delivery of the carriers laden with cellular structures, which
has created varied opportunities and scope of merits like; prolongation in circulation and alleviating
immunogenicity improvement of the site-specific active targeting. Platelet-inspired nanoparticles or
medicines are the most recent nanotechnology-based drug targeting systems used mainly to treat
blood-related disorders, tumors, and cancer. The present review encompasses the current approach of
platelet-inspired nanoparticles or medicines that have boosted the scientific community from versatile
fields to advance biomedical sciences. Surprisingly, this knowledge has streamlined to development
of newer diagnostic methods, imaging techniques, and novel nanocarriers, which might further
help in the treatment protocol of the various diseased conditions. The review primarily focuses on
the novel advancements and recent patents in nanoscience and nanomedicine that could be streamlined
in the future for the management of progressive cancers and tumor targeting. Rigorous technological
advancements like biomimetic stem cells, pH-sensitive drug delivery of nanoparticles, DNA
origami devices, virosomes, nano cells like exosomes mimicking nanovesicles, DNA nanorobots,
microbots, etc., can be implemented effectively for target-specific drug delivery.
The Synthesis and Application of Ionic Liquid Functionalized Mesoporous
Silica SBA-15 for Organic Synthesis
Authors: Ziarani Ghodsi Mohammadi , Javadi Fatemeh , Mohajer Fatemeh , Badiei Alireza 
Published: March 2022

Abstract:
Ionic liquid functionalized mesoporous silica compounds present significant advantages
in organic synthesis as catalysts. There are various preparation procedures for the
synthesis of diverse ionic liquid catalysts, which have different catalytic properties with various
roles in organic reactions. Therefore, due to the increment in the usage of mesoporous
materials in the industry and numerous pieces of research, in this article, the information on
the development of ionic liquids supported on SBA-15 between the years 2014 and 2021 was
gathered.
Rheumatoid Arthritis and JAK-STAT Inhibitors: Prospects of Topical Delivery
Authors: Nishal Suchitra , Jhawat Vikas , Phaugat Parmita , Dutt Rohit 
Published: March 2022

Abstract:Rheumatoid arthritis (RA) is the most common musculoskeletal disease in the world. The clinical prospects have increased tremendously since the advent of biological agents as therapy options. NSAIDs such as indomethacin, celecoxib, and etoricoxib are used often in the treatment of RA but off-target effects decreased their use. DMARDs such as methotrexate and etanercept were also effective in the treatment of RA, but tolerance to methotrexate developed in many cases. Janus kinase inhibitors (JAKi) have also gained popularity as a treatment option for rheumatoid arthritis. Tofacitinib is the foremost JAK inhibitor that is used to treat RA as an individual agent or in combination with other DMARDs. The most frequently used route of administration for JAKi is oral. Since oral formulations of JAK inhibitors have a number of health hazards, such as systemic toxicity and patient noncompliance, topical formulations of JAK inhibitors have emerged as a preferable alternative for administering JAK inhibitors. Tofacitinib delivered topically, seems to have the potential to eliminate or reduce the occurrences of negative effects when compared to tofacitinib taken orally. Given the scarcity of knowledge on the techniques for topical distribution of JAKi, more effort will be required to develop a stable topical formulation of JAKi to address the limitations of oral route. The current review looks at JAK inhibitors and the ways that have been used to generate topical formulations of them.
Smartphone Apps for Managing Antithrombotic Therapy: Scoping Literature Review
Authors: Praus Friederike , Krzowski Bartosz , Walther Tabea , Gratzke Christian , Balsam Paweł , Miernik Arkadiusz , Pohlmann Philippe Fabian 
Published: March 2022

Background
Antithrombotic therapy is complex and requires informed decisions and high therapy adherence. Several mobile phone apps exist to either support physicians in the management of antithrombotic therapies or to educate and support patients. For the majority of these apps, both their medical evidence and their development background are unknown.

Objective
This review aims to investigate the available literature describing high-quality apps for managing antithrombotic therapy based on professional scientific information.

Methods
Keywords and Medical Subject Heading terms were used to search MEDLINE via PubMed and Ovid between December 2019 and January 2022. Inclusion criteria were the availability of full text and publications in the English language. Apps that solely focused on atrial fibrillation were excluded. Qualitative findings were thematically synthesized and reported narratively.

Results
Out of 149 identified records, 32 were classified as eligible. We identified four groups: (1) apps for patients supporting self-management of vitamin K antagonists, (2) apps for patients increasing therapy adherence, (3) educational apps for patients, and (4) apps for physicians in supporting guideline adherence.

Conclusions
Throughout the evaluated data, patients from all age groups receiving antithrombotic drugs expressed the desire for a digital tool that could support their therapy management. In addition, physicians using mobile guideline-based apps may have contributed to decreased adverse event rates among their patients. In general, digital apps encompassing both user-friendly designs and scientific backgrounds may enhance the safety of antithrombotic therapies. However, our evaluation did not identify any apps that addressed all antithrombotic drugs in combination with perioperative stratification strategies. Currently, strict regulations for smartphone apps seem to negatively affect the development of new apps. Therefore, new legal policies for medical digital apps are urgently needed.
Pilot Testing in the Wild: Feasibility, Acceptability, Usage Patterns, and Efficacy of an Integrated Web and Smartphone Platform for Bipolar II Disorder
Authors: Fletcher Kathryn , Lindblom Katrina , Seabrook Elizabeth , Foley Fiona , Murray Greg 
Published: March 2022

Background
Bipolar II disorder (BD-II) is associated with significant burden, disability, and mortality; however, there continues to be a dearth of evidence-based psychological interventions for this condition. Technology-mediated interventions incorporating self-management have untapped potential to help meet this need as an adjunct to usual clinical care.

Objective
The objective of this pilot study is to assess the feasibility, acceptability, and clinical utility of a novel intervention for BD-II (Tailored Recovery-oriented Intervention for Bipolar II Experiences; TRIBE), in which mindfulness-based psychological content is delivered via an integrated web and smartphone platform. The focus of the study is evaluation of the dynamic use patterns emerging from ecological momentary assessment and intervention to assist the real-world application of mindfulness skills learned from web-delivered modules.

Methods
An open trial design using pretest and posttest assessments with nested qualitative evaluation was used. Individuals (aged 18-65 years) with a diagnosis of BD-II were recruited worldwide and invited to use a prototype of the TRIBE intervention over a 3-week period. Data were collected via web-based questionnaires and phone interviews at baseline and 3-week follow-up.

Results
A total of 25 participants completed baseline and follow-up assessments. Adherence rates (daily app use) were 65.6% across the 3-week study, with up to 88% (22/25) of participants using the app synergistically alongside the web-based program. Despite technical challenges with the prototype intervention (from user, hardware, and software standpoints), acceptability was adequate, and most participants rated the intervention positively in terms of concept (companion app with website: 19/25, 76%), content (19/25, 76%), and credibility and utility in supporting their management of bipolar disorder (17/25, 68%). Evaluation using behavioral archetypes identified important use pathways and a provisional model to inform platform refinement. As hypothesized, depression scores significantly decreased after the intervention (Montgomery-Asberg Depression Rating Scale baseline mean 8.60, SD 6.86, vs follow-up mean 6.16, SD 5.11; t24=2.63; P=.01; Cohen d=0.53, 95% CI 0.52-4.36).

Conclusions
Our findings suggest that TRIBE is feasible and represents an appropriate and acceptable self-management program for patients with BD-II. Preliminary efficacy results are promising and support full development of TRIBE informed by the present behavioral archetype analysis. Modifications suggested by the pilot study include increasing the duration of the intervention and increasing technical support.