bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluasi Penyimpanan Obat di Instalasi Farmasi RSU Wismarini Pringsewu
Authors: Primadiamanti Annisa , Hasni Nur Alfi Mufida , Ulfa Ade Maria 
Published: April 2022

Penyimpanan obat bertujuan untuk mempertahankan mutu obat dari kerusakan akibat penyimpanan yang tidak baik, memudahkan pencarian dan pengawasan obat-obatan. Penelitian ini merupakan penelitian deskriptif non eksperimental menggunakan data yang diambil secara retrospektif dengan melakukan wawancara mendalam, observasi dan daftar tilik. Data kuantitatif diperoleh berdasarkan acuan Permenkes nomor 72 tahun 2016 dan menggunakan indikator penyimpanan obat sebagai faktor pendukungnya. Hasil dari penelitian ini menunjukkan penyimpanan sediaan obat di Instalasi Farmasi Rumah Sakit Umum Wismarini Pringsewu pada poin persyaratan penyimpanan, komponen penyimpanan, pengaturan penyimpanan dan metode penyimpanan sudah sesuai dengan standar Permenkes RI No.72 tahun 2016. Poin pengelolaan obat emergency sudah sesuai dengan standar Permenkes RI No.72 tahun 2016. Namun pada indikator nilai TOR, persentase obat kadaluarsa dan stok mati belum sesuai dengan standar yaitu nilai TOR sebesar 7 kali/tahun dengan standar sebesar 10-23kali/tahun dan persentase obat kadaluarsa 1,09% dengan standar < 0,2 %, stok mati sebesar 13,4% dengan standar 0%.
UJI AKTIVITAS VARIASI GELLING AGENT MASKER GEL PEEL-OFF EKSTRAK KULIT BUAH JERUK NIPIS (Citrus aurantifolia-pericarpium) TERHADAP BAKTERI Staphylococcus aureus
Authors: Ulfa Ade Maria , Chusniasih Dewi , Octavia Theodora 
Published: April 2022

Staphylococcus aureus merupakan salah satu bakteri penyebab jerawat. Kandungan kimia pada ekstrak kulit buah jeruk nipis (Citrus aurantifolia-pericarpium) yang tergolong sebagai antibakteri diharapkan dapat menghambat pertumbuhan bakteri staphylococcus aureus. penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak kulit buah jeruk nipis yang mampu menghambat pertumbuhan Staphylococcus aureus serta mengetahui gelling agent mana yang lebih baik antara HPMC atau Karbopol 940 pada sediaan masker gel peel–off. Kulit buah jeruk nipis diekstrak menggunakan etanol 96% dengan menggunakan metode maserasi dan dibuat masing-masing konsentrasi yaitu 5%,10%,15%,20% dan 25%. Kemudiaan hasil ekstrak dilakukan uji aktivitas antibakteri menggunakan metode sumuran dengan media Nutrient Agar. Bakteri staphylococcus aureus dengan konsentrasi terkecil didapat 1.59 mm dan konsentrasi terbesar didapatkan 11.54 mm. Pada sediaan masker gel peel-off formulasi yang digunakan yaitu masker gel peel-off gelling agent HPMC dan karbopol 940 didapat rata-rata zona hambat 11.55 mm dan 11.20 mm. Pengujian sifat fisik sediaan masker gel peel-off dapat disimpulkan masker gel peel-off (HPMC dan Karbopol 940) sama-sama memenuhi parameter pengujian sedangkan untuk daya hambat terhadap bakteri staphylococcus aureus, sediaan masker gel peel–off gelling agent HPMC lebih baik dibandingkan masker gel peel–off gelling agent karbopol 940.
ANALISIS PROGRAM POS PEMBINAAN TERPADU PENYAKIT TIDAK MENULAR (PTM) TAHUN 2020 DI PUSKESMAS PALPA BANDAR LAMPUNG
Authors: Subagio Derian 
Published: April 2022

FAKULTAS KEDOKTERANUNIVERSITAS MALAHAYATISkripsi, 2021 Derian subagioxvii+ Halaman+ 2Tabel+ Gambar ANALISIS PROGRAM POS PEMBINAAN TERPADU PENYAKIT TIDAK MENULAR DI PUSKESMAS PALAPA BANDAR LAMPUNG TAHUN 2017ABSTRAKLatar Belakang : Penyakit Tidak Menular (PTM) merupakan salah satu masalah kesehatan yang menjadi perhatian nasional maupun global pada saat ini. Indonesia merupakan salah satu negara yang telah menetapkan program nasional untuk menanggulangi masalah PTM melalui program Posbindu PTM (Pos Pembinaan Terpadu) PTM yang termasuk penyakit-penyakit seperti DM, Kanker, Penyakit Jantung dan Pembuluh Darah (PJPD), penyakit paru obstruktif kronis (PPOK). Tujuan : Penelitian ini bertujuan untuk menganalisis tentang program Posbindu PTM yang telah berjalan di Puskesmas Palapa Bandar Lampung tahun 2020. Metode : Jenis penelitian ini adalah kualitatif dengan pendektan analitik. Pengumpulan data yang penulis gunakan adalah melalui teknik wawancara tidak terstruktur atau wawancara terbuka. Analisis data dengan cara triangulasi dengan subyek pemegang program di Puskesmas Palapa, Kepala Puskesmas Palapa, Pemegang Program di Dinas Kesehatan Kota Bandar Lampung, kader. Hasil dan Kesimpulan : Hasil penelitian menunjukan bahwa Program Posbindu PTM di Puskesmas Palapa belum berjalan dengan baik. Kata Kunci : Program Pos Pembinan Terpadu Penyaki Tidak Menular.
EVALUASI RASIONALITAS PENGGUNAAN ANTIBIOTIK PADA PASIEN ANAK DIAGNOSA ISPA DENGAN METODE GYSSENS DI INSTALASI RAWAT JALAN PUSKESMAS PUGUNG RAHARJO LAMPUNG TIMUR
Authors: ANGIN MARTIANUS PERANGIN , Yasir Angga Saputra , Wafika Umu 
Published: April 2022

ISPA merupakan infeksi saluran pernapasan yang menimbulkan gejala batuk, pilek disertai dengan demam yang dapat berlangsung sampai dengan 14 hari yang dapat mengenai sepanjang saluran pernapasan. Peresepan antibiotika dalam pelayanan kesehatan yang kurang tepat dapat meningkatkan resiko terhadap keamanan pasien. Tujuan penelitian yaitu untuk memberi sebuah gambaran tentang evaluasi rasionalitas penggunaan antibiotika pasien anak rawat jalan secara kualitatif di Puskesmas Pugung Raharjo Lampung Timur. Penelitian ini merupakan penelitian non-eksperimental dengan menggunakan data retrospektif. Data yang diambil merupakan rekam medik anak ISPA berumur 5 – 11 tahun sebanyak 38 pasien.Pola penggunaan antibiotik ini dengan satu jenis antibiotik yaitu amoxicillin.Hasil penelitian ini menunjukan yaitu karakteristik pasien ISPA lebih banyak terjadi pada anak laki – laki sebanyak 21 pasien (55,3%). Menurut penelitian metode Gyssens diperoleh data lengkap (VI; 100%), antibiotika sesuai indikasi (V; 100%), tidak ada antibiotik lebih efektif (IVA; 100%), tidak ada pemilihan antibiotik lebih aman (IVB; 100%), pemberian tidak terlalu lama (IVC; 100%), pemberian tidak terlalu singkat (IVD; 100%), pemberian tidak tepat dosis (IIA; 5,26%), interval pemberian tepat (IIB; 100%), rute pemberian tepat (IIC; 100%), pemberian tepat waktu (I; 100%), tepat/bijak (0; 94,74%). Kesimpulannya yaitu penggunaan antibiotika yang kurang rasional menyebabkan perlunya pengawasan untuk meningkatkan rasionalitas penggunaanantibiotika.
Uji Daya Larvasida Ekstrak Aseton Dan Etanol Kulit Buah Kakao (Theobroma cacao L.) Terhadap Larva Aedes aegypti
Authors: Chusniasih Dewi , Ulfa Ade Maria , Kurniawan Agung 
Published: April 2022

Kulit buah kakao memiliki komponen fitokimia yang berpotensi sebagai larvasida alami. Tujuan dari penelitian ini adalah mengetahui perbandingan daya larvasida ekstrak aseton dan etanol kulit buah kakao (Theobroma cacao L.). Metode penelitian yang digunakan adalah metode eksperimental yang dianalisis secara deskriptif.Hasil uji efektivitas ekstrak aseton memiliki nilai rata-rata kematian larva lebih baik pada konsentrasi 2% sebesar 14,6 daripada nilai rata-rata kematian larva ekstrak etanol pada konsentrasi 2% sebesar 14. Berdasarakn hasil uji LC50 menunjukan ekstrak aseton kulit buah kakao efektif dalam membunuh larva Aedes aegypti dengan nilai LC50 sebesar 1,9633% dan masuk dalam kategori kuat, sedangkan ektrak etanol memiliki nilai LC50 sebesar 1,9498% dan tergolong dalam kategori kuat.
IFLA supports bibliographic studies
Authors: Likhovid T. F. 
Published: April 2022

The author reviews the activity of the International Federation of Library Associations (IFLA) in the area of bibliography and bibliographic studies since the second half of 20th century. IFLA bibliography-oriented divisions with the account to the recent structural changes are named. The changes are approved at 2021 World Library and Information Congress. The key projects in blbliography and cataloguing are discussed: Universal Bibliographic Control (UBC), UNISIST (United Nations International Scientific Information System); National Information Systems; International Standard Bibliographic Description (ISBD). The current technological projects, e. g. FRBR, FRAD, FRSAD, FRBRoo, PRESSoo, IFLA LRM, are to regulate and standardize requirements to bibliographic records to support multiaspect information retrieval. The author argues that IFLA has transformed its bibliographic activities from large-scale global projects intended to embrace various types of documents and to unify bibliographic records toward narrower technological projects oriented toward disclosing data on format and contents of documents and efficient utilization of bibliographic information. The author emphaszes that IFLA is now focusing on the UN’s Sustainable Development Goals agenda and 2030 Culture Coalition.The author based her article on the paper delivered at the Third World Bibliographic Congress (Novosibirsk, 27–29 April, 2021).
PEMBUATAN PUPUK ORGANIK CAIR DARI URINE KAMBING
Authors: Hafyamsyah Nur , Pristiyono Pristiyono , Halim Abdul 
Published: April 2022

Kondisi lahan pertanian di Indonesia sudah kritis akibat penggunaan pupuk kimia oleh petani. Petani yang mengabaikan akibat penggunaan pupuk kimia dilahan pertanian maka produktivitas tanah yang tidak baik dan lingkungan tercemar. Pemanfaatan urine kambing menjadi Pupuk Organik Cair (POC) merupakan salah satu bentuk inovasi yang ramah lingkungan. Urine kambing yang bisanya menjadi sumber bau (pencemaran udara) dapat di gunakan sebagai bahan utama pembuatan Pupuk Organik Cair. Pengabdian kepada masyarakat ini dilakukan dengan teknik penyuluhan (praktek dilapangan) dengan pendekatan edukatif yang mengandung unsur pendidikan yang dapat mendinamisasikan masyarakat menuju kemajuan yang diinginkan. Pendekatan edukatif ini dilakukan beberapa tahap yaitu, tahap persiapan, tahap melayani dan tahap evaluasi. Hasil dalam pembuatan pupuk organik cair adalah meningkatkan produksi pertanian baik dari kualitas maupun kuantitas dan mampu meningkatkan produktivitas lahan dengan jangka panjang dan dapat mencegah terjadinya degradasi (kemrosotan) lahan.
PENINGKATAN KOMPETENSI GURU MELALUI PELATIHAN KOMPUTER AKUNTANSI MYOB VERSI 22 PADA SMK TARUNA TERPADU 2 BOGOR
Authors: Pratiwi Ratih , Sastrawan Uding , Ginoga Lesia Fatma 
Published: April 2022

Sekolah Menengah Kejuruan (SMK) merupakan salah satu lembaga pendidikan formal yang menyelenggarakan pendidikan kejuruan pada jenjang pendidikan menengah guna mempersiapkan guru didik untuk bekerja dalam bidang keahlian tertentu. Sistem pembelajaran di SMK lebih difokuskan kepada praktikum dan terapan dibandingkan Sekolah Menengah Umum (SMU) dengan bobot teori lebih besar. Salah satu bidang kompetensi akuntansi bagi lulusan SMK adalah terampil menyusun laporan keuangan berbasis aplikasi komputer. Pada SMK Taruna Terpadu hanya terdapat satu guru yang memahami tentang akuntansi berbasis aplikasi komputer, sehingga diperlukannya pelatihan untuk para guru akuntansi yang lain agar dapat memahami dan menghubungkan antara pencatatan akuntansi manual dengan pencatatan akuntansi menggunakan aplikasi komputer. Untuk menciptakan link and match kurikulum Sekolah Menengah Kejuruan dan Pendidikan Vokasi, maka menyelenggarakan pelatihan pengoperasian software MYOB Accounting versi 22 perlu dilakukan. Tujuan kegiatan ini adalah meningkatkan pemahaman, kompetensi guru dalam penyajian laporan keuangan di SMK Taruna Terpadu 2 Bogor. Pelaksanaan kegiatan dilakukan dengan metode ceramah, simulasi dan praktik pencatatan setiap transaksi keuangan. Pelatihan dimulai dari persiapan data base perusahaan, pencatatan transaksi yang meliputi pembelian, penjualan, bank, jurnal penyesuaian dan tahapan akhir adalah penyajian laporan keuangan. Secara umum, peserta pelatihan dapat mengoperasikan MYOB Versi 22 dengan baik dan diimplementasikan dalam pembelajaran kepada siswa.
Pengaruh Dana Alokasi Umum, Pendapatan Asli Daerah dan Dana Alokasi Khusus terhadap Kemiskinan dengan Pertumbuhan Ekonomi sebagai Variabel Intervening Tahun 2015-2019
Authors: Panggabean Helena Louise , Hariani Danarti , B A. Yanuar 
Published: April 2022

Poverty is an important indicator to see the welfare of a country. Papua is a province in Indonesia that has the highest number of poor people. The purpose of this study is to determine the factors that influence the level of poverty in Papua Province, so that it can be a reference for the government in efforts to overcome poverty, especially in Papua. This study uses quantitative research methods and uses secondary data obtained from the annual report of the Province, the Director General of Balance, Ministry of Finance, and BPS Papua Province. The data analysis used is panel data regression analysis. The results show that there is a significant effect of General Allocation Fund and Special Allocation Fund on Economic Growth, while Regional Original Income does not have a significant effect on Economic Growth. Other results also show that Economic Growth, Regional Original Income, and Special Allocation Funds have a significant effect on poverty, while the General Allocation Fund does not have a direct effect on poverty. The results of the mediation test show that economic growth is not able to mediate the relationship between the variables of the General Allocation Fund, Regional Original Income and the Special Allocation Fund on Poverty.
BALANCE SCORECARD : ANALISIS KEPEMIMPINAN, MOTIVASI DAN KEPUASAN KERJA PERAWAT DENGAN KINERJA RUMAH SAKIT
Authors: Jainurakhma Janes 
Published: April 2022

Abstract
The spirit of work in employees arised when the love of work is high, and it was formed because of motivation and job satisfaction in the employee, in addition to the existence of a leadership style that’s able to provide comfort to employees in work. The study's goal was to analyze nurses' leadership relationships, motivation and job satisfaction with hospital performance using the balance scorecard approach at Gatoel Mojokerto Hospital. The design of this research is crossectional analytics. These variables are leadership, motivation, and job satisfaction as independent variables and hospital performance as dependent variable. The population of this study are all nurses in Gatoel Hospital Mojokerto City as many as 138 nurses. The sample was taken with a simple random sampling technique as many as 102 respondents. The data was collected with a questionnaire instrument and tested with the rho spearman test. The results showed the p value al of independent variables showed a value = 0.00 so that the value of p value < 0.05 then this shows that there is a relationship between independent variables (leadership, motivation, and job satisfaction of nurses) with variable dependent (performance). To maximize the achievement of the implementation of balanced scorecard as part of the management control system, hospital management should not only take measurements but also look at supporting factors and obstacles in each indicator so that further efforts can be made to the existence of the main performance indicators.
Relation between socio-demographic factors and professionalism among nurses in Saudi Arabia: A comparative analysis
Authors: Alshumrani Hussein , Albagawi Bander , Villareal Sandro , Areola Jr Benito , Albaqawi Hamdan , Algamdi Saleh , Alerwi Abdulrahman , Altheban Ahmed Saad , Alanazi Seham 
Published: April 2022

Background: Analyzing how nurses handle professionalism in their careers will help all concerned individuals identify areas of concern to develop and enhance further to achieve or maintain a high degree of professionalism.
Objective: This study aimed to determine the level of professionalism among nurses and its differences according to socio-demographic characteristics.
Methods: A quantitative cross-sectional approach was utilized in three significant regions of Saudi Arabia. A simple random sampling technique was employed with 305 respondents, resulting in a 95.9% response rate. A Google Form survey was used to collect the data between January and April 2021.
Results: Nurses perceived themselves highly in professional organization (Mean = 3.94, SD = 0.17), belief in public service (Mean = 3.91, SD = 0.22), belief in self-regulation (Mean = 3.97, SD = 0.08), sense of calling (Mean = 4.01, SD = 0.13), and belief in autonomy (Mean = 3.71, SD = 0.15). There was no significant difference between gender and professional organization, belief in public service, self-regulation, or belief in autonomy. Still, there was a significant difference in belief in public service (t = 2.794; p = 0.006) and sense of calling (t = 4.290; p = 0.001). As to age, only belief in self-regulation was significant (t = 5.984; p = 0.003). Moreover, the educational qualifications reached an insignificant difference in professionalism. Conversely, the type of facility has been found to have reached significant differences with a professional organization (F = 3.057; p = 0.029), belief in public service (F = 4.130; p = 0.007), beliefs in regulation (F = 3.452; p = 0.017), sense of calling (F = 3.211; p = 0.023), and belief in autonomy (F = 5.995; p = 0.001). Lastly, the current position found no significant difference in professionalism.
Conclusion: Nurses in the Kingdom of Saudi Arabia perceived themselves as highly professional, and male nurses were found to have a sense of calling more than their female counterparts. Age, educational qualification, and current position had no significant difference in professionalism. Conversely, the type of facility had a significant difference with the belief in autonomy. These findings support and sustain the role of nurses in this 21st-century health care that is significantly needed to provide the most quality care.
Sustainable Green University: Waste Auditing, German Jordanian University as a Case Study
Authors: Hindiyeh Muna , Jaradat Mustafa , Albatayneh Aiman , Alabdellat Batool , Al-Mitwali Yazan , Hammad Bashar 
Published: April 2022

In order to get on the path of sustainable development as a society as a whole, a great transformation is required. Universities are embedded in society and networked with it through various forms of interaction; they influence social discourses and often have a decisive influence on them. As educational institutions, universities have to take a critical stance on the state of our earth and actively fulfill their responsibility. The German Jordanian University (GJU), like any other university, produces solid and hazardous waste. A waste audit was done to identify the waste streams and the opportunities for reinforcing waste reduction, recycling, and composition while enhancing the comprehensive sustainability of a waste management program. The results showed that an average of 2,500 kg of waste was produced per week. The composition of the waste generated at the GJU main campus was 1,051 kg (41%) for paper and cardboard, 875 kg (35%) for plastics, 325 kg (13%) for biowaste, and 275 kg for other wastes. The performed UI GreenMetric showed high potential in the programs to reduce the use of paper and plastic on campus and the treatment of toxic waste with a score of 75 points. The results of this study indicate high potential in the recycling program for university waste, organic and inorganic waste treatment, and sewage disposal. The results for these indicators were moderate, a score of 75 points out of 300 points. Thus, more focus and actions should be placed on these indicators to enhance a sustainable green campus.
A Genomic Signature Reflecting Fibroblast Infiltration Into Gastric Cancer Is Associated With Prognosis and Treatment Outcomes of Immune Checkpoint Inhibitors
Authors: Lu Yi , Li Dan , Cao Yixin , Ying Leqian , Tao Qing , Xiong Fen , Hu Zhangmin , Yang Yufei , Qiao Xuehan , Peng Chen , Zhu Dongqin , Wang Deqiang , Li Xiaoqin 
Published: April 2022

Background: The immunotherapy efficacy in gastric cancer (GC) is limited. Cancer-associated fibroblasts (CAFs) induce primary resistance to immunotherapy. However, CAF infiltration in tumors is difficult to evaluate due to the lack of validated and standardized quantified methods. This study aimed to investigate the impact of infiltrating CAFs alternatively using fibroblast-associated mutation scoring (FAMscore).Methods: In a GC cohort from Affiliated Hospital of Jiangsu University (AHJU), whole exon sequencing of genomic mutations, whole transcriptome sequencing of mRNA expression profiles, and immunofluorescence staining of tumor-infiltrating immune cells were performed. GC data from The Cancer Genome Atlas were used to identify genetic mutations which were associated with overall survival (OS) and impacted infiltrating CAF abundance determined by transcriptome-based estimation. FAMscore was then constructed through a least absolute shrinkage and selection operator Cox regression model and further validated in AHJU. The predictive role of FAMscore for immunotherapy outcomes was tested in 1 GC, one melanoma, and two non-small-cell lung cancer (NSCLC-1 and -2) cohorts wherein participants were treated by immune checkpoint inhibitors.Results: FAMscore was calculated based on a mutation signature consisting of 16 genes. In both TCGA and AHJU, a high FAMscore was an independent predictor for poor OS of GC patients. FAMscore was associated with immune-associated genome biomarkers, immune cell infiltration, and signaling pathways of abnormal immunity. Importantly, patients with high FAMscore presented inferiority in the objective response rate of immunotherapy compared to those with low FAMscore, with 14.6% vs. 66.7% (p&lt;0.001) in GC, 19.6% vs. 68.2% (p&lt;0.001) in NSCLC-1, 23.1% vs 75% (p = 0.007) in NSCLC-2, and 40.9% vs 75% (p = 0.037) in melanoma. For available survival data, a high FAMscore was also an independent predictor of poor progression-free survival in NSCLC-1 (HR = 2.55, 95% CI: 1.16–5.62, p = 0.02) and NSCLC-2 (HR = 5.0, 95% CI: 1.13–22.19, p = 0.034) and poor OS in melanoma (HR = 3.48, 95% CI: 1.27–9.55, p = 0.015).Conclusions: Alternative evaluation of CAF infiltration in GC by determining the FAMscore could independently predict prognosis and immunotherapy outcomes. The FAMscore may be used to optimize patient selection for immunotherapy.
Hydrophobic Outer Membrane Pores Boost Testosterone Hydroxylation by Cytochrome P450 BM3 Containing Cells
Authors: Bertelmann Carolin , Mock Magdalena , Koch Rainhard , Schmid Andreas , Bühler Bruno 
Published: April 2022

The implementation of biocatalytic steroid hydroxylation processes at an industrial scale still suffers from low conversion rates. In this study, we selected variants of the self-sufficient cytochrome P450 monooxygenase BM3 from Bacillus megaterium (BM3) for the hydroxylation of testosterone either at the 2β- or 15β-position. Recombinant Escherichia coli cells were used as biocatalysts to provide a protective environment for recombinant enzymes and to ensure continuous cofactor recycling via glucose catabolism. However, only low initial whole-cell testosterone conversion rates were observed for resting cells. Results obtained with different biocatalyst formats (permeabilized cells, cell-free extracts, whole cells) indicated a limitation in substrate uptake, most likely due to the hydrophilic character of the outer membrane of E. coli. Thus, we co-expressed nine genes encoding hydrophobic outer membrane proteins potentially facilitating steroid uptake. Indeed, the application of four candidates led to increased initial testosterone hydroxylation rates. Respective whole-cell biocatalysts even exceeded activities obtained with permeabilized cells or cell-free extracts. The highest activity of 34 U gCDW−1 was obtained for a strain containing the hydrophobic outer membrane protein AlkL from Pseudomonas putida GPo1 and the BM3 variant KSA14m. Overall, we show that the straightforward application of hydrophobic outer membrane pores can boost whole-cell steroid conversion rates and thus be game-changing with regard to industrial steroid production efficiency.