bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation risk of lymph nodal invasion in patients with early-stage cervical cancer: Cervical cancer application
Authors: Guani Benedetta , Gaillard Thomas , Teo-Fortin Ly-Ann , Balaya Vincent , Feki Anis , Paoletti Xavier , Mathevet Patrice , Plante Marie , Lecuru Fabrice 
Published: August 2022

IntroductionLymph node status is a major prognostic factor in early-stage cervical cancer. Predicting the risk of lymph node metastasis is essential for optimal therapeutic management. The aim of the study was to develop a web-based application to predict the risk of lymph node metastasis in patients with early-stage (IA1 with positive lymph vascular space invasion, IA2 and IB1) cervical cancer.Materials and methodsWe performed a secondary analysis of data from two prospective multicenter trials, Senticol 1 and 2 pooled together in the training dataset. The histological risk factors were included in a multivariate logistic regression model in order to determine the most suitable prediction model. An internal validation of the chosen prediction model was then carried out by a cross validation of the ‘leave one out cross validation’ type. The prediction model was implemented in an interactive online application of the ‘Shinyapp’ type. Finally, an external validation was performed with a retrospective cohort from L’Hôtel-Dieu de Québec in Canada.ResultsThree hundred twenty-one patients participating in Senticol 1 and 2 were included in our training analysis. Among these patients, 280 did not present lymph node invasion (87.2%), 13 presented isolated tumor cells (4%), 11 presented micrometastases (3.4%) and 17 macrometastases (5.3%). Tumor size, presence of lymph-vascular space invasion and stromal invasion were included in the prediction model. The Receiver Operating Characteristic (ROC) Curve from this model had an area under the curve (AUC) of 0.79 (95% CI [0.69– 0.90]). The AUC from the cross validation was 0.65. The external validation on the Canadian cohort confirmed a good discrimination of the model with an AUC of 0.83.DiscussionThis is the first study of a prediction score for lymph node involvement in early-stage cervical cancer that includes internal and external validation. The web application is a simple, practical, and modern method of using this prediction score to assist in clinical management.
Edaravone use in acute intracerebral hemorrhage: A systematic review and meta-analysis of randomized controlled trials
Authors: Qin Mingzhen , Feng Luda , Yang Chinyu , Wei Dawei , Li Tingting , Jiang Ping , Guan Jinzhi , Zhang Xinyue , Shi Xinyi , Liang Ning , Lai Xinxing , Zhou Li , Zhang Chi , Gao Ying 
Published: August 2022

Background: Edaravone alleviates neurological deficits among patients with intracerebral hemorrhage; however, its effects on mortality and long-term functional outcomes remain unknown.Objective: To assess clinical outcomes associated with edaravone initiated within 7 days of symptoms onset in intracerebral hemorrhage.Methods: We systematically searched PubMed, Embase, Cochrane Library, CiNii, China National Knowledge Infrastructure, Chinese VIP information, Wanfang Data, and SinoMed for relevant randomized controlled trials from their inception to 1 May 2021 and conducted a comprehensive systematic review and meta-analysis (PROSPERO registration number: CRD42019147801). All-cause mortality and long-term functional outcomes were taken as the primary outcomes.Results: A total of 38 randomized controlled trials including 3,454 participants with acute intracerebral hemorrhage were included. The selected articles were of poor quality. Meta-analysis revealed that edaravone could not reduce all-cause mortality [relative risk (RR) = 0.51; 95% confidence interval (CI) (0.11–2.32); p = 0.38]. No studies reported on long-term functional outcomes in those trials. In addition, edaravone alleviated neurological deficits [mean difference (MD) = −5.44; 95% CI (−6.44 to −4.44); p&lt;0.00001], improved the activities of daily living [MD = 8.44; 95% CI (7.65–9.23); p&lt;0.00001], reduced the hematoma volume [MD = −4.71; 95% CI (−5.86 to −3.56); p&lt;0.00001], and increased treatment response [RR = 1.26; 95% CI (1.22–1.31); p&lt;0.00001]. In terms of safety outcome, there was no significant difference between the edaravone group and the control groups [RR = 1.67; 95% CI (0.92 to 3.06); p = 0.09].Conclusion: Till date, edaravone does not associate with mortality reduction when initiated within 7 days of intracerebral hemorrhage onset. The effect of edaravone on long-term functional outcomes remains unknown due to lack of data. Although edaravone alleviated neurological deficits, improved activities of daily living, and reduced hematoma volume, we cautiously interpreted the results owing to the overall poor quality and high heterogeneity of the included trials. Presently, the results are insufficient to support edaravone as a routine treatment option for acute intracerebral hemorrhage.
Screening for severe drug-drug interactions in patients with multiple sclerosis: A comparison of three drug interaction databases
Authors: Hecker Michael , Frahm Niklas , Bachmann Paula , Debus Jane Louisa , Haker Marie-Celine , Mashhadiakbar Pegah , Langhorst Silvan Elias , Baldt Julia , Streckenbach Barbara , Heidler Felicita , Zettl Uwe Klaus 
Published: August 2022

Background: Patients with multiple sclerosis (MS) often undergo complex treatment regimens, resulting in an increased risk of polypharmacy and potential drug-drug interactions (pDDIs). Drug interaction databases are useful for identifying pDDIs to support safer medication use.Objective: To compare three different screening tools regarding the detection and classification of pDDIs in a cohort of MS patients. Furthermore, we aimed at ascertaining sociodemographic and clinical factors that are associated with the occurrence of severe pDDIs.Methods: The databases Stockley’s, Drugs.com and MediQ were used to identify pDDIs by screening the medication schedules of 627 patients. We determined the overlap of the identified pDDIs and the level of agreement in pDDI severity ratings between the three databases. Logistic regression analyses were conducted to determine patient risk factors of having a severe pDDI.Results: The most different pDDIs were identified using MediQ (n = 1,161), followed by Drugs.com (n = 923) and Stockley’s (n = 706). The proportion of pDDIs classified as severe was much higher for Stockley’s (37.4%) than for Drugs.com (14.4%) and MediQ (0.9%). Overall, 1,684 different pDDIs were identified by at least one database, of which 318 pDDIs (18.9%) were detected with all three databases. Only 55 pDDIs (3.3%) have been reported with the same severity level across all databases. A total of 336 pDDIs were classified as severe (271 pDDIs by one database, 59 by two databases and 6 by three databases). Stockley’s and Drugs.com revealed 47 and 23 severe pDDIs, respectively, that were not included in the other databases. At least one severe pDDI was found for 35.2% of the patients. The most common severe pDDI was the combination of acetylsalicylic acid with enoxaparin, and citalopram was the drug most frequently involved in different severe pDDIs. The strongest predictors of having a severe pDDI were a greater number of drugs taken, an older age, living alone, a higher number of comorbidities and a lower educational level.Conclusions: The information on pDDIs are heterogeneous between the databases examined. More than one resource should be used in clinical practice to evaluate pDDIs. Regular medication reviews and exchange of information between treating physicians can help avoid severe pDDIs.
The direct and indirect effects of length of hospital stay on the costs of inpatients with stroke in Ningxia, China, between 2015 and 2020: A retrospective study using quantile regression and structural equation models
Authors: Su Ming , Pan Dongfeng , Zhao Yuan , Chen Chen , Wang Xingtian , Lu Wenwen , Meng Hua , Su Xinya , Liang Peifeng 
Published: August 2022

ImportanceLength of hospital stay (LOHS) is the main cost-determining factor of hospitalization for stroke patients. However, previous analyses involving LOHS did not consider confounding or indirect factors, or the effects of other factors on LOHS and inpatient costs.ObjectiveTo investigate the direct and indirect effects of LOHS on the hospitalization costs of inpatients with ischemic and hemorrhagic stroke.Design, setting, and participantsThis was a population-based, retrospective, and observational study that analyzed data acquired from the Nationwide Inpatient Sample between 2015 and 2020 relating to ischemic and hemorrhagic stroke in Ningxia, China.Main outcomes and measuresHospitalizations were identified by the International Classification of Diseases 10th Revision (ICD-10). Inpatient costs were described by the median M (P25, P75). We used a quantile regression model to estimate the linear relationships between a group of independent variables X and the quantile of the explained variable hospitalization cost (Y). A structural equation model (SEM) was then used to investigate the direct and indirect effects of LOHS on inpatient costs.ResultsThe study included 129,444 patients with ischemic stroke and 15,525 patients with hemorrhagic stroke. The median LOHS was 10 (8–13) days for ischemic stroke and 15 (10–22) days for hemorrhagic stroke. The median M (P25, P75) of inpatient costs was $1020 (742–1545) for ischemic stroke and 2813 (1576–6191) for hemorrhagic stroke. The total effect of LOHS on inpatient costs was 0.795 in patients with ischemic stroke. The effect of yearof discharge (X4) and CCI (X8) on inpatient costs was dominated by an indirect effect through the LOHS. The indirect effect was −0.071 (84.52% of the total effect value) and 0.034 (69.39% of the total effect value), respectively. The total effect of LOHS on inpatient costs in patients with hemorrhagic stroke was 0.754. The influence of CCI on inpatient costs was dominated by an indirect effect through LOHS; the indirect effect value was −0.028 (77.78% of the total effect value). The payment type, surgery, method of discharge, and hospital level also exerted an impact on inpatient costs by direct and indirect effects through the LOHS.Conclusions and relevanceLength of hospital stay (LOHS) was identified as the main factor influencing hospitalization costs. However, other social factors were shown to indirectly influence hospitalization costs through the LOHS. Taking effective measures to further reduce hospitalization costs remains an effective way to control hospitalization costs for stroke patients.
Scoping review of the current landscape of AI-based applications in clinical trials
Authors: Cascini Fidelia , Beccia Flavia , Causio Francesco Andrea , Melnyk Andriy , Zaino Andrea , Ricciardi Walter 
Published: August 2022

BackgroundClinical trials are essential for bringing new drugs, technologies and procedures to the market and clinical practice. Considering the design and the four-phase development, only 10% of them complete the entire process, partly due to the increasing costs and complexity of clinical trials. This low completion rate has a huge negative impact in terms of population health, quality of care and health economics and sustainability. Automating some of the process' tasks with artificial intelligence (AI) tools could optimize some of the most burdensome ones, like patient selection, matching and enrollment; better patient selection could also reduce harmful treatment side effects. Although the pharmaceutical industry is embracing artificial AI tools, there is little evidence in the literature of their application in clinical trials.MethodsTo address this issue, we performed a scoping review. Following the PRISMA-ScR guidelines, we performed a search on PubMed for articles on the implementation of AI in the development of clinical trials.ResultsThe search yielded 772 articles, of which 15 were included. The articles were published between 2019 and 2022 and the results were presented descriptively. About half of the studies addressed the topic of patient recruitment; 12 articles reported specific examples of AI applications; five studies presented a quantitative estimate of the effectiveness of these tools.ConclusionAll studies present encouraging results on the implementation of AI-based applications to the development of clinical trials. AI-based applications have a lot of potential, but more studies are needed to validate these tools and facilitate their adoption.
Perfil sociodemográfico e clínico-obstétrico de mulheres diagnosticadas com doença trofoblástica gestacional
Authors: Barreto Andrezza Silvano , Pereira Emanuelly Vieira , de Melo Ana Virginia Fialho , Vidal Cláudia Rejane Pinheiro Maciel , Dos Santos Cristina Poliana Rolim Saraiva , Castro Régia Christina Moura Barbosa 
Published: August 2022

Doença trofoblástica gestacional (DTG) é um grupo heterogêneo de distúrbios associados à gravidez, manifestados por proliferação anômala de tecido trofoblástico. Objetivou-se apresentar o perfil sociodemográfico e clínico-obstétrico de mulheres diagnosticadas com DTG. Trata-se de pesquisa descritiva, retrospectiva, transversal, documental com abordagem quantitativa realizada em um hospital de referência em Fortaleza, Ceará, Brasil. A população foi composta por todas as pacientes diagnosticadas com DTG no período de dezembro de 2017 a 2018, sendo a mostra composta por 110 mulheres. A coleta de dados ocorreu de janeiro a julho de 2019. Utilizou-se instrumento composto por dados sociodemográficos, aspectos clínicos e seguimento ambulatorial. Os resultados foram apresentados descritivamente e em tabelas. As participantes encontravam-se com idade mínima 14 e máxima 49, predominantemente com ensino médio completo (38,2%), ocupação do lar (39,1%), parceiro/a sexual (62,7%) e 57,3% eram da região metropolitana ou interiorana. Quanto aos dados obstétricos, as participantes tiveram como média as variáveis gestação de 2,4, parto de 1,12 e aborto de 0, 75. Quanto aos sinais e sintomas, 72,7% apresentaram dor em baixo ventre, 91,8% referiram algum tipo de secreção transvaginal, 20% tiveram hiperêmese gravídica, 2,7% desenvolveram pré-eclâmpsia, em 57,3% apresentaram vólume abdominal aumentado, 18,2% expeliram as vesículas, 20% desenvolveram cistose ovariana e em 78,2% evidenciaram níveis elevados de β-HCG. Conclui-se que os dados sociodemográficos e clínico obstétricos estão em consonância com a literatura encontrada. O procedimento de resolução da patologia é o indicado pela literatura, evidenciando uma excelente assistência prestada.
Efeito da idade de abate no desempenho da carcaça e qualidade da carne de coelhos
Authors: De Souza Dayse Oliveira , Gomes Augusto Vidal da Costa , Gonzaga Iaçanã Valente Ferreira , Silva Vinicius Pimentel 
Published: August 2022

Objetivou-se avaliar a influência da idade de abate no desempenho zootécnico, características de carcaça e qualidade da carne de coelhos. Foram avaliados 48 coelhos da raça Nova Zelândia branca, de ambos os sexos, distribuídos em delineamento inteiramente casualizado com 4 tratamentos (60, 70, 80 e 90 dias de idade ao abate), com doze repetições cada. Os animais foram alimentados com ração comercial ad libitum. Os dados de desempenho e de carcaça foram avaliados por análise de variância e regressão linear. Além disso, os animais submetidos às diferentes idades ao abate apresentaram aumento linear (P<0,05) para peso final e conversão alimentar, decréscimo linear para o consumo diário e ganho de peso diário. Os maiores custos médio da ração (US$/Kg) observados para os coelhos abatidos aos 80 e 90 dias de idade. O peso das carcaças quente e resfriada, o peso dos membros anteriores e posteriores, bem como o peso das regiões lombar e cervicotorácica observou-se aumento linear em função das idades. Quanto à qualidade da carne observou-se que a relação carne/osso foi superior para a deposição muscular e, quanto ao pH da carcaça resfriada, houve redução linear em relação aos animais mais velhos. As diferentes idades ao abate avaliadas não afetaram a composição química da carne. Em suma a idade indicada para abate de coelhos da raça Nova Zelândia Branco é aos 70 dias, devido à viabilidade econômica, associada a musculosidade fornecida pela relação carne/osso e peso que os animais atingem nestas condições e período, o que demonstra precocidade desejável.
Meningkatkan Keterampilan Proes Sains Anak Usia 5-6 Tahun melalui Metode Eksperimen Mencampur Warna di PAUD Permata Hati Desa Jampang
Authors: Damayanti Anita , - Mawaddah 
Published: August 2022

Penelitian ini dilatarbelakangi oleh adanya keterampilan proses sains pada anak usia 5-6 tahun yang masih belum berkembang optimal, sehingga penulis tergerak untuk meneliti apa penyebab kelemahan tersebut sambil mengajukan solusi dengan penerapan metode eksperimen mencampur warna. Tujuan penelitan ini adalah meneliti peningkatan keterampilan proses sains anak usia 5-6 tahun melalui metode eksperimen menacampur warna di PAUD Permata Hati Desa Jampang. Hasil penelitian meunjukan bahwa terdapat peningkatan yang signifikan metode eksperimen mencampur warna terhadap keterampilan proses sains anak. Hal ini terbukti dari hasil perolehan persentase dari pra siklus sebesar 31%, siklus I 54% dan siklus II 82%. Dengan demikian dapat disimpulkan bahwa metode eksperimen mencampur warna dapat meningkatkan keterampilan proses sains anak usia 5-6 tahun di PAUD Permata Hati Desa Jampang. Hasil penelitian ini diharapkan dapat bermanfaat untuk pihak-pihak terkait seperti kepala sekolah, guru, orang tua dan siswa/peserta didik
Genealogía de un discurso de resistencia: cartas mapuche-williche a autoridades hispano-criollas del siglo XIX
Authors: Cárcamo Alejandro 
Published: August 2022

The Mapuche-Williche sought an equal relationship between each society in spite of the conquest of their territory, as well as they sought that the Hispanic-Creole don’t interfere in their internal affairs. This means that they tried to establish equal intercultural relationships but in reality, societies were asymmetric, considering that Chilean Hispanic-Creole’s authorities pegged themselves as rulers. Public speeches of Mapuche-Williche’s resistance, as so-called "memorials", have appeared since the late nineteenth century and let us observe the search of equal relationship in the public sphere. But, before observing the emergence of those memorials as discourse of resistance, we must observe the process that allowed them to appear. This paper seeks to build part of the genealogy of the Mapuche-Williche's memorials based on the letters they sent to those previously pleaded authorities in the Fütawillimapu during the nineteenth century.
Gold nanowire electrodes for flexible organic thin-film transistors
Authors: Takane Satoshi , Noda Yuki , Toyoshima Naomi , Uemura Takafumi , Bando Yuki , Sekitani Tsuyoshi 
Published: August 2022

Abstract
A flexible organic thin-film transistor (OTFT) with gold nanowire (AuNW) networks as source/drain/gate electrodes (AuNW-OTFT) was fabricated and characterized. Its fabrication was enabled by the successful formation of AuNW network electrodes on a flexible thin-film substrate using the thermal pressing transfer method. The fabricated AuNW-OTFT exhibited typical p-type characteristics (mobility: 6.0 × 10−2 cm2 V−1 s−1, on/off ratio: 105) and a lower contact resistance than that of an OTFT with vacuum-deposited Au electrodes in the same configuration. Furthermore, the AuNW-OTFT demonstrated high mechanical durability, as proven by the absence of significant characteristic changes before and after bending (bending radius:0.8 mm).
Migración centroamericana y pandemia: las (des-)razones de la seguridad
Authors: Espinoza de los Monteros Javier 
Published: August 2022

La presente contribución explora la relación en la migración irregular y la pobreza; lo hace en el contexto de la pandemia y respecto a la migración centroamericana, la cual tiene como país de destino y objetivo eua y transita por México. Se analiza y reflexiona sobre la manera en que han sido tratados durante su tránsito y destino en dichos territorios, sobre la exclusión y la violencia de la que han sido objeto en virtud de las carencias económicas y del color de la piel. Ellos han sido representados como un problema que pone en riesgo la seguridad nacional, junto al terrorismo y el crimen organizado. Han sido inventados como delincuentes y, durante esta pandemia, como la principal fuente de contagio y de propagación del virus. De este modo, se han utilizado políticas punitivas de exclusión y represión por parte del Estado mexicano y del norteamericano y, asimismo, se ha generado un trato discriminatorio y selectivo respecto a esta clase de personas.
Los migrantes solamente han buscado hacer efectivos sus derechos de forma universal, como la libertad, la satisfacción de sus necesidades básicas y alcanzar mejores condiciones de vida. Solamente que para el derecho y la política de los Estados ellos no son sujetos sino objetos, cuerpos extraños y son la amenaza que tiene que ser frenada.
La política de la exclusión tiene como fundamento el principio de seguridad. Este ha sido instrumentalizado y manipulado para legitimar practicas injustificadas y arbitrarias por parte de los gobiernos y democracias contemporáneas. Aquí analizamos cuál ha sido, pues, la función de la seguridad en relación con la alteridad, sus desrazones.
الالتزام التنظيمي وعلاقته بمستوى تقييم الاداء ووسائل التدريس للرضا الوظيفي لدى تدريسيي التربية الرياضية جامعة الكوفة
Authors: عبيد علياء حسين 
Published: August 2022

يهدف البحث الحالي إلى معرفة مدى الالتزام التنظيمي لدى أعضاء الهيئة التدريسية في جامعة الكوفة , بالإضافة إلى معرفة مدى العلاقة بين الالتزام التنظيمي وتقييم الأداء وطرائق التدريس , ولتحقيق ذلك فقد تم استخدام استبيان لقياس وجهة نظر أعضاء الهيئة التدريسية تجاه الالتزام التنظيمي عن طريق مقياس الالتزام التنظيمي والمتكون من (7) فقرات ’ أما تقييم الأداء – وطرائق التدريس فتم قياسه عن طريق استبيان أيضا . وبعد الحصول على النتائج عن طريق استخدام الحقيبة التعليمية أل spss تبين إن أعضاء الهيئة التدريسية لديهم التزام تنظيمي , بالإضافة إلى وجود علاقة ارتباط بين الالتزام التنظيمي و تقييم الأداء وكذلك هناك علاقة ارتباط بين الالتزام التنظيمي وطرائق التدريس. The research aims to study the organizational commitment of the faculty members at the University of Kufa, in addition to knowing the extent of the relationship between organizational commitment and performance evaluation and teaching methods, and to achieve this has been the use of a questionnaire to measure the perspective of faculty members toward organizational commitment through organizational commitment scale consisting of (7) paragraphs' The performance - and teaching methods to assess shoved measured through a questionnaire as well. After getting results through the use of educational bag all spss show that faculty members have the organizational commitment, as well as a correlation between organizational commitment and performance evaluation of the relationship as well as there is a correlation between organizational commitment and methods of teaching .