bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Shabtis of Tjuyu (CG 51037–51040)
Authors: Mekawy Ouda Ahmed M. 
Published: September 2022

This paper investigates the shabtis of Tjuyu (CG 51037–51040), the wife of the ‘god’s father’, Yuya, and mother of Queen Tiye, the wife of the famous King Amenhotep III. In my previous article in JEA 107, I investigated the shabtis of her husband Yuya which are kept at the Egyptian Museum in Cairo (CG 51024–34, CG 51036) and the Metropolitan Museum of Fine Art in New York (MMA 30.8.56–30.8.58). In this paper, I explore the state of preservation of Tjuyu’s shabtis, as they have not been studied since the discovery of the tomb of Yuya and Tjuyu (KV46) in 1905, as well as their inscriptions which were not copied, and their form, decoration, and manufacture. A comparison with the shabtis of Yuya will further highlight the differences regarding the materials, methods of manufacture, and the style of inscriptions. [Formula: see text]
A national audit of the management of HIV-2 in adults in the UK
Authors: Tickell-Painter Maya , Chadwick David R , Deayton Jane R , Reeves Iain , van Halsema Clare L 
Published: September 2022

Background HIV-2 is rare in the UK. Many UK centres therefore only treat small numbers of people and there are few clinical trials to guide treatment. The British HIV Association (BHIVA) 2010 guidelines for management of HIV-2 formed the basis for this national audit, which aims to describe current practice and adherence to guidelines. Methods All UK centres providing HIV care were contacted via the BHIVA “Members Matters” newsletter, and asked to submit anonymised, retrospective data for individuals living with HIV-2 accessing care at their service. Results Thirty-five sites responded and data were analysed for 167 individuals. Nearly half of individuals accessed care at one of four large London centres (77/167, 46%). Most people living with HIV-2 have taken antiretroviral therapy (ART) (132/167, 79%). The most common reasons for initiating treatment were clinical disease (34/89, 38%) and pregnancy (11/89, 12%). Most treatment-naïve individuals were initiated on a protease inhibitor based regimen (70/89, 79%). The use of integrase strand transfer inhibitor based regimens has increased over time. A significant minority of patients did not have baseline drug resistance testing performed, despite having a detectable viral load (15/52, 29%). Virological failure occurred in a minority of individuals (21/132, 16%); the most common drug regimen change in this context was the addition of an integrase strand transfer inhibitor (12/26 regimen changes, 46%). Conclusions Most individuals living with HIV-2 were managed according to national guidance, with key areas for improvement including the choice of ART, drug resistance testing and the management of virological failure. It is hoped that this national audit, performed in conjunction with the updated 2021 BHIVA guidelines will improve the care of individuals living with HIV-2 in the UK.
Coronavirus and Health Anxiety of Nursing Students in Two Different Countries
Authors: Sahin Karaduman Gul , Basak Tulay , Santana Fialho Sim-Sim Maria Margarida 
Published: September 2022

Introduction: Even under normal circumstances, anxiety is quite common among nursing students. Therefore, this study compared nursing students’ health and coronavirus anxiety in two European countries. Method: The sample of the descriptive, cross-sectional study consisted of 685 undergraduate students studying at two different nursing schools in Turkey and Portugal. The study data were collected with the Personnel Data Collection Form, Coronavirus Anxiety Scale, and Short Health Anxiety Inventory. Results: While there was no difference between the Coronavirus Anxiety Scale scores of Turkish and Portuguese nursing students ( p > .05), a statistically significant difference was found between the Short Health Anxiety Inventory total scores and negative consequences scores ( p < .05). Discussion: Against the pandemic that the whole world is experiencing, it is recommended to compare nursing students in a cultural context and take precautions.
The Effectiveness of Language-Specific Personal Care Education on Improving the Knowledge and Skills of Vietnamese American In-Home Supportive Service Caregivers
Authors: Vu Thu Hoang , Ju Eunae , Rousseau Julie , Gibbs Lisa , Saville Neika , Lee Jung-Ah 
Published: September 2022

Background: In-Home Supportive-Services (IHSS) caregivers provide personal care assistance to low-income older adults. According to the California Social Service Department, 20.2% of IHSS caregivers spoke Vietnamese in one county. The purpose of this project was to improve the knowledge and skills among these Vietnamese American caregivers by providing a language-specific and culturally appropriate education on personal care. Methods: The project used a pre- and post-test design. Under the guidance of nursing faculty, four Vietnamese-speaking nursing students provided a 2-hr educational program on personal care (e.g., bathing, oral care) to registered Vietnamese IHSS caregivers. A pre- and post-survey was conducted. Results: Overall, 55 caregivers completed the surveys. The surveys showed significant increases in confidence in knowledge and skills related to personal care topics (all ps < .001). Conclusion: The findings demonstrated that the cultural and language-specific education was effective in increasing knowledge and confidence of Vietnamese IHSS caregivers related to personal care for older adults.
Is Weight Loss During Chemotherapy for Pancreatic Cancer Prognostic?
Authors: Davis Mellar , Vanenkevort Erin , Varun Samji , Young Amanda , Correa Ordonez Irina , Brown Jason , Wojtowicz Mark 
Published: September 2022

Background Predicting poor survival outcomes early in palliative chemotherapy is important to the timing of palliative care. Weight loss during chemotherapy if prognostic would lead to early palliative care. Method We collected demographics, stage, chemotherapy, chemotherapy cycles, weight, healthcare utilization, comorbidities (Charleson Comorbid Index), tumor markers, and weight changes over 60 days. We defined 3 groups of patients: 1. Weight gain to <.5% weight loss, 2. Weight loss< 2% and 3. Weight loss of >2%. A Chi-square test assessed differences in weight during treatment. Time-to-event analysis was expressed in a Kaplan Meier curve. Results 93 individuals died of pancreatic cancer in 2018 and 2019. The median age was 71.2 years. Forty-three had stage I and II, 40 stages III and IV cancers, and 10 had unknown stages. Most received FOLFIRINOX and gemcitabine/nab-paclitaxel chemotherapy. Thirty-six gained to lost < .5% during chemotherapy,8 lost < 2% and 49 patients lost > 2% of their weight. Mortality was available in 55 of 93 patients. Median survival was 16.6 months in those with weight gain to < .5% weight loss, 17.28 months for those with < 2% weight loss, and 20.5 months for those with > 2% weight loss ( P = .42). Discussion Weight loss over 60 days did not predict a poor prognosis in this small retrospective study; larger prospective studies may clarify the prognostic importance of weight loss during chemotherapy. Conclusion In this small retrospective study, weight loss over 60 days did not predict poor survival.
Aminoglycoside Pharmacokinetics in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy
Authors: Krueger Chelsea K. , Bruno Jeffrey J. , Tverdek Frank P. , Hernandez Mike , Abudayyeh Ala 
Published: September 2022

Background: There are few studies describing aminoglycoside pharmacokinetics during continuous renal replacement therapy (CRRT). Objective: To characterize the effect of CRRT on aminoglycoside clearance and volume of distribution ( Vd). Methods: Retrospective observational pharmacokinetic study of adult critically ill oncologic patients who received a first dose of amikacin or tobramycin during CRRT between February 2012 and May 2017. Study outcomes included aminoglycoside clearance, Vd, and attainment of the target peak: MIC (minimum inhibitory concentration) ratio as a surrogate for dosing appropriateness. Results: In total, 80 patients were included, sustained low-efficiency dialysis (SLED), n = 49; continuous venovenous hemodialysis (CVVHD), n = 19; continuous venovenous hemofiltration (CVVH), n = 12. Fifty-one patients received amikacin at a median dose of 14.5 mg/kg per actual body weight and achieved a median peak level of 26.7 mg/L. Twenty-nine patients received tobramycin at a median dose of 6.5 mg/kg actual body weight and achieved a median peak level of 10.3 mg/L. The median aminoglycoside clearance was 63.1 mL/min and was similar between CRRT modality groups ( P = 0.97). The median Vd was 0.47 L/kg and was different between the SLED and CVVH groups ( P = 0.007). Attainment of target peak: MIC occurred in 29% in the total study population and 44% in the subgroup of 23 patients with isolates tested for aminoglycoside susceptibility. Conclusion and Relevance: Critically ill oncology patients undergoing CRRT exhibited reduced clearance and expanded Vd that was not significantly different between CRRT modalities. Current dosing regimens led to low peak concentrations and poor attainment of pharmacokinetic targets.
Comparison of ultrasonographic renal measurements in kittens up to 3 months of age and young cats
Authors: Castiglioni Maria CR , Rahal Sheila C , Silva Jeana P , Mamprim Maria J 
Published: September 2022

Objectives This study aimed to evaluate renal measurements by B-mode ultrasound in kittens during their first 3 months and compare them with those of young adult cats. Methods Forty-eight healthy mixed-breed cats (24 males and 24 females) were enrolled in this study. The cats were divided into six age groups: groups 1–5 (kittens) and group 6 (young adult cats). Each kidney was examined using B-mode imaging and the following measurements taken: renal length (RL), renal height (RH), renal width (RW), cortical thickness (CoT), medullary thickness (MdT) and corticomedullary ratio (CMr). The ratio and correlation of RL to aortic diameter (AoD) and the length of the fifth/sixth lumbar vertebrae (LLV) were also determined. Results Among groups, there was a statistically significant difference between RW, renal volume (RV), CoT, MdT and CMr. The smallest renal dimensions were obtained in the youngest kittens (up to 10 days of age), including RL (1.84 ± 0.40 cm), RH (1.14 ± 0.17 cm), RW (1.25 ± 0.20 cm) and RV (1.47 ± 0.68 ml). A strong correlation was observed between RL:AoD and RL:LLV, allowing for linear regression equations and reference intervals for RL:AoD and RL:LLV to be created for each age group. Conclusions and relevance B-mode ultrasound showed that renal measurements in kittens differed from those in young adult cats, and that the renal dimensions, renal CoT and CMr increased with the growth of the cat. The RL-LLV ratio is a reliable method for measuring RL according to age group.
Multimodal evaluation of osteosarcoma choroidal metastasis
Authors: Fernández Mancebo Federico M. , Inga M. Eugenia , Daich Varela Malena 
Published: September 2022

Background Osteosarcoma (OS) is the most common primary bone carcinoma. Adulthood most frequent intraocular malignant tumor is choroidal metastasis; however, these are rarely related to sarcomas. There are only two OS-related choroidal metastasis cases reported in the literature, both prior to 1970. Case presentation A 20-year-old man with a history of tibial OS, right leg amputation, and lung and brain metastases, presented with decreased vision in his right eye (OD). Ophthalmic examination revealed a best-corrected visual acuity of hand movements and a large, posterior pole, nodular, subretinal mass, with associated fluid. B-scan revealed a heterogeneous lump, with medium/high reflectivity, and a height-to-base ratio (HBR) of 1-1.2, approximately. Computerized tomography (CT) scan showed a hyperdense and contrast-enhanced mass, while on magnetic resonance imaging (MRI) the lesion appeared T1-isointense and T2-hypointense. Conclusion Choroidal OS metastasis can appear as a pink nodule with high HBR and intralesional hyperreflective deposits. Sudden visual changes in individuals with OS-related systemic metastatic disease should be monitored closely by ophthalmology and oncology jointly.
Hinged tarsal flap: A novel technique for canthal tendon reconstruction
Authors: Awad Mary , Wilde Craig , Tambe Katya 
Published: September 2022

Background/Objectives Reconstruction of the medial canthal region is challenging due to the complex regional anatomy. Options to reconstruct a medial canthal tendon sacrificed during tumour removal is limited. We present a novel surgical technique where hinged tarsal flap serves to substitute the canthal tendons. Methods This is a retrospective consecutive case series of five patients that underwent canthal reconstruction using this novel technique between May and December 2020. Electronic patient records and medical photograph database were reviewed. Patient demographics, co-morbidities, location and histology of the lesion, size of the resultant defect, reconstructive technique and post-operative complications were noted. Results All patients had good eyelid stability with no malposition, lagophthalmos or exposure keratopathy. No or minimal distraction of the eyelid from the globe, good cosmetic outcomes and no troublesome watering was reported. No wound dehiscence, no sight loss and no further surgical intervention was warranted. Conclusion Multiple techniques have previously been described to reattach the medial canthal tendon with silk or supramid sutures. Transnasal wiring, stainless-steel screw and mini-plate fixation are also described, but carry a high risk of complications and are unfamiliar amongst most oculoplastic surgeons. Our technique is quick and simple and utilises autogenous tissue without breaching the periosteum which acts as a natural barrier to tumour infiltration. Refashioning the canthal tendon aids to lengthen the remaining eyelid stump, reducing the horizontal length required to reform the newly constructed eyelid and facilitates the reconstruction.
Visual outcomes of non-diffractive extended-depth-of-focus and enhanced monofocal intraocular lenses: A case-control study
Authors: Sabur Huri , Unsal Ugur 
Published: September 2022

Objective To compare the visual outcomes of a non-diffractive extended-depth-of-focus (EDoF) intraocular lens (IOL) with an enhanced monofocal IOL. Methods We evaluated 76 eyes from 38 patients who had undergone bilateral cataract surgery with implantation of either an EDoF IOL (AcrySof IQ Vivity, n = 40 eyes) or an enhanced monofocal IOL (Tecnis Eyhance, n = 36 eyes). Objective refraction, monocular and binocular uncorrected and corrected distance visual acuity (UDVA, CDVA), uncorrected and distance-corrected intermediate visual acuity (UIVA, DCIVA), uncorrected and distance-corrected near visual acuity (UNVA, DCNVA), binocular defocus curves, contrast sensitivity, halo and glare perception, and spectacle independence were compared. Results Monocular and binocular UDVA, CDVA, UIVA, and DCIVA were comparable in both groups, whereas UNVA and DCNVA were significantly better with the Vivity group than with the Eyhance group. The two groups had no statistically significant difference regarding photopic and scotopic contrast sensitivities or halo and glare perception. Compared to the Eyhance IOL, the Vivity IOL had a larger landing zone in the defocus curve and provided higher spectacle independence for near vision. Conclusion Both the AcrySof IQ Vivity and Tecnis Eyhance IOLs had excellent distant and intermediate visual acuity, while the former had more satisfactory near vision outcomes with greater spectacle independence rate. No differences were obtained between two IOLs in terms of patient satisfaction and visual disturbances such as halo and glare.
Osteoporosis, bisphosphonates, and ocular inflammation
Authors: Nouraeinejad Ali 
Published: September 2022

Background Osteoporosis, as a musculoskeletal disease, is very common, especially in the era of aging society. It is described by a reduction in bone strength and increased risk of fractures, which are linked to considerable morbidity, mortality, and high healthcare burdens. Bisphosphonates are the most commonly used drugs to manage osteoporosis and they consequently reduce fracture risk. However, one of the clinical challenges is fear of side effects in patients who are using bisphosphonates as the administration of these drugs is lengthy. Ocular inflammation has been reporting as one of the potential vision-threatening side effects of bisphosphonates. Purpose To review previously reported ocular inflammation in patients taking bisphosphonates. Method A literature survey was conducted using databases in order to collect data for a narrative review of published reports regarding ocular side effects of bisphosphonates. Results People taking bisphosphonates were at a relatively low risk of ocular inflammation, with the onset from a few hours after exposure up to more than 3 years. The release of inflammatory mediators mainly by activated gamma delta T cells in response to bisphosphonates was the main cause of ocular inflammation. Conclusion Strategies for treating patients with osteoporosis should consider the potential ocular side effects of bisphosphonates. Ocular inflammation, as one of the side effects of bisphosphonates, is a serious sight-threatening sign and should be taken seriously. Greater awareness of the association between bisphosphonate use and ocular inflammation may allow for earlier identification and timely treatment of future cases.
Comparison of safety and efficacy of silicone hydrogel contact Lens-assisted CXL and accelerated CXL in keratoconus patients with thin corneas
Authors: Uysal Betul Seher , Ozmen Mehmet Cuneyt , Yuksel Murat , Aydın Bahri , Bilgihan Kamil 
Published: September 2022

Purpose To evaluate the efficacy and safety of silicone hydrogel contact lens-assisted corneal cross-linking (CL-CXL) and compare 12-month visual and topographic outcomes with accelerated CXL using hypo-osmolar riboflavin (A-CXL) in keratoconus patients with thin corneas (below 400 μm with epithelium). Methods This retrospective study included 27 eyes of 27 keratoconus patients who underwent CL-CXL (n = 14) or A-CXL (n = 13). Uncorrected and corrected distance visual acuity (UDVA and CDVA) and data obtained from corneal topography were analyzed at baseline and again at 6- and 12-month follow-ups. Corneal demarcation line depth (DLD) was measured at one month, and changes in the corneal endothelial cell density (ECD) at 12 months were also assessed. Results Mean UDVA improved significantly in both groups at 12 months (all p < 0.05). Maximum keratometry (K-max) decreased by 1.04 ± 1.90 D in the CL-CXL group and by 0.87 ± 1.89 D in the A-CXL group at 12 months, which was not statistically significant (all p>0.05). Total corneal higher-order aberrations (HOAs) analysis showed a significant improvement in only the CL-CXL group at 12 months (p = 0.041). Average DLD was 227.18 ± 65.60 μm in the CL-CXL group and 245.30 ± 66.84 μm in the A-CXL group (p = 0.275). No significant change in ECD was found in either group (all p>0.05). Mean changes in UDVA, CDVA, K-max, K-mean, HOAs, and ECD were not statistically significant between the groups (all p>0.05). Conclusions Silicone hydrogel CL-assisted CXL seems as effective as A-CXL in halting keratoconus progression in thin corneas with no side effects during the one-year follow-up period.
Child and adolescent psychiatry staff’s knowledge on pain management
Authors: Geremek Adam , Ruby Lisa , Lindner Clemens , Niederberger Uwe , Schild Ursula , Jung Martin , Soyka Oliver , Siniatchkin Michael 
Published: September 2022

Objective To assess the level of child and adolescent psychiatric staff’s knowledge regarding pain management, to determine group differences between the medically more educated (physicians, nurses) and the less educated (psychologists, educators, special therapists) and to investigate the influence of gender, age, or professional experience as well as staff’s own pain experiences. Methods A total of 193 staff members from different professional backgrounds from three independent child and adolescent psychiatry clinics in Northern Germany were tested using the German version of the Pediatric Nurses’ Knowledge and Attitudes Survey Regarding Pain Shriner’s revision (PNKAS-Sr). Results In total, the staff scored correctly 66% of the inventory questions. There was no difference between medically more educated and less educated staff members regarding the knowledge of pain management. The main factors influencing PNKAS score were age, profession, and pain education training. Conclusions Although chronic pain is not one of the main aspects of continuing education in child and adolescent psychiatry, the resulting level of knowledge was comparable to results of similar surveys with paediatric staffs. Nevertheless, further education is needed to enhance knowledge and understanding of children’s pain in child psychiatry staff in order to professionally treat patients with chronic somatic and mental illnesses.
Serum biomarkers associated with radiographic skeletal maturity indicators: A systematic review and meta-analysis
Authors: Tripathi Tulika , Ganesh Gayatri , Singh Navneet , Rai Priyank 
Published: September 2022

Objective: To evaluate the relevant scientific literature to determine the association between different serum biomarker levels and radiographic skeletal maturity indicators. Data Search, Screening and Eligibility: A literature search was carried out on PubMed, Cochrane Library, Google Scholar, Semantic Scholar, Science Direct and Opengrey.eu up to November 2021 and 7466 records were retrieved via the electronic search. Study selection, data extraction and subsequent risk of bias assessment (RoB) was carried out independently by two authors. In case of any discrepancy, a third author was consulted. Results: After the exclusion of duplicates and the application of inclusion exclusion criteria, 19 studies (published in 25 articles) were included in the systematic review out of which 17 had a cross-sectional and two had a cohort study design. For the meta-analysis, based on the homogeneity, five cross-sectional studies measuring serum IGF-1 levels were incorporated. The meta-analysis revealed that the serum IGF-1 levels peak at the CS4 stage (401.77 ng/mL [333.50 – 470.05]) in the pooled group. However, in the subgroup analysis, it was found that the serum IGF-1 levels peak at CS3 in girls (422.82 ng/mL [377.46–468.18]) and CS4 in boys (487.04 ng/mL [391.83–582.25]). Conclusion: Among the various biomarkers evaluated, serum IGF-1 was the most associated with different stages of radiographic skeletal maturity indicators with its levels peaking at CS3 in girls and CS4 in boys.