bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial intelligence assisted thermoelectric materials design and discovery
Authors: Lu Na , Han Guangshuai , Sun Yixuan , Feng Yining , Lin Guang 
Published: August 2022

Abstract
Materials discovery from infinite earth repository is considered the bottleneck of each revolutionary technological progress. The discovery of the new materials is hindered by the labor-intensive and time-consuming process. Although machine learning techniques shown the excellent capability for speeding up materials discovery, it is still challenging to obtain effective material feature representations and making a precise prediction of the material properties are still challenging.
This work focuses on developing an automatic material design and discovery framework enabled by data-driven AI models. We utilize the material's thermoelectric (TE) properties prediction as a baseline to demonstrate the investigation logistic. The framework works in a closed-loop mode. Starting from the well-established TE materials databases, we develop a TE material encoding method and TE material screening model by using machine learning technology. The models show excellent accuracy for TE properties prediction. Furthermore, the developed AI models have identified 6 novel promising p-type TE materials and 8 novel promising n-type TE materials. Evaluated by the Density-functional Theory (DFT) calculation, the prediction results have a good agreement with the realistic material's TE property. The proposed framework well accelerates the design and discovery of the new functional materials.
Wireless Charging Scheme with Secured Data Transmission
Authors: Lin Chun-Liang , Wong Zi-Qian , Yang Jamie 
Published: August 2022

Abstract
This research task proposes a magnetic resonant coupling wireless power transfer (MRC-WPT) scheme for electric vehicles, which realizes secure data communication between the wireless charging station and the electric vehicle using binary phase shift-keying (BPSK) data transmission, thereby waving any radio frequency (RF) communication links. The secondary side is designed to accept power while transmits data back to the primary side simultaneously. The BPSK design ensures data transmission robustness to against disturbance interference. The data is encrypted by the user's biometric features for information security. The magnetic resonance performs better than that of the traditional magnetic induction in the power transmission efficiency against coil misalignments. With the Internet of Thing (IoT) architecture, the encrypted data can be stored and retrieved via the cloud server.
Chromatin-modifying enzymes as modulators of nuclear size during lineage differentiation
Authors: Meng Lingjun 
Published: August 2022

Abstract
The mechanism of nuclear size determination and alteration during normal lineage development and cancer pathologies which is not fully understood. As recently reported, chromatin modification can change nuclear morphology. Therefore, we screened a range of pharmacological chemical compounds that impact the activity of chromatin-modifying enzymes, in order to get a clue of the specific types of chromatin-modifying enzymes that remarkably effect nuclear size and shape. We found that interrupted activity of chromatin-modifying enzymes is associated with nuclear shape abnormalities. Furthermore, the activity of chromatin-modifying enzymes perturbs cell fate determination in cellular maintenance and lineage commitment. Our results indicated that chromatin-modifying enzyme regulates cell fate decision during lineage differentiation and is associate with nuclear size alteration.
Validation of day and night delivery of melatonin in a rat ovariectomized model of osteoporosis
Authors: Li Tian-lin , Tao Zhou-shan , Liu He-dong , Ren Mao-xian , Zhou Zhi , Jiang Wen-kai , Yang Min 
Published: August 2022

Abstract
Aim
To explore the difference in the efficacy of intraperitoneal injection of exogenous melatonin of daytime or nighttime in the treatment of postmenopausal osteoporosis.
Methods
In this study, 40 rats were randomly divided into four groups: sham operation group (Sham), ovariectomy (OVX), and daytime melatonin injection group (OVX + DMLT, 9:00, 30mg/ kg/d) and nighttime injection of melatonin (OVX + NMLT, 22:00, 30 mg/kg/d). During the period, we measured the concentration of melatonin in the blood of each group 1 hour after the injection of melatonin. After three months of treatment, the rats were sacrificed. The distal femur, blood and femoral marrow cavity contents were saved. The rest of the samples were tested by Micro-CT, histology, biomechanics and molecular biology. Blood was used for bone metabolism marker measurements.
Results
Compared with the nighttime injection, the bone mass of the rats was significantly increased after the daytime injection treatment. All morphometric parameters increased, only Tb.Sp decreased. Histologically, the bone microarchitecture was also better. In the biomechanical experiment, the femur samples of the day treatment group were able to withstand greater loads and deformation. In molecular biology experiments, bone formation-related molecules increased, while bone resorption-related molecules decreased. After treatment with melatonin injection at night, the expression of MT2 was significantly decreased.
Conclusion
Daytime injection of melatonin is more effective in preventing bone loss.
Design and synthesis of Brønsted-Lewis acidic tetraimidazolyl ionic liquids for efficient catalytic conversion of glucose to 5-hydroxymethylfurfural in water/1-octanol
Authors: Zhao Jian , Li Chao , Fan Xiaodong , Liu Hao , Liu Ziqi , Zhang Jingchao , Sun Zhizhong , Chu Wenyi 
Published: August 2022

Abstract
5-Hydroxymethylfurfural (5-HMF) is a key platform compound in the catalytic conversion of biomass. Ionic liquids (ILs) have attracted much attention due to their unique tunable structures and wide applications. A series of Brønsted-Lewis acidic tetraimidazolyl ionic liquids ([TeimILs]) were designed and synthesized by introducing Brønsted acid (-SO3H) in the cation and Lewis acid (AlCl3) in the anion. Among them, [Teim-PS][AlCl4]4 exhibited good catalytic performance in the conversion of glucose to 5-HMF in the biphasic system of H2O: 1-octanol= 1:2, and the conversion of glucose and the yield of 5-HMF can reach 94 % and 71.3 %, respectively. [Teim-PS][AlCl4]4 as the catalyst can be reused at least six times, the yield of 5-HMF does not decrease significantly. The biphasic system was beneficial for the recycling of [Teim-PS][AlCl4]4 and the separation of 5-HMF. In addition, the kinetic analysis was performed on the catalytic system, and its activation energy was only 49.98 KJ/mol. This work provides a new solution for the efficient and green conversion of glucose to HMF.
Association between control group therapy and magnitude of clinical benefit of cancer drugs.
Authors: Molto Consolacion , Tibau Ariadna , Bujosa Aida , Tapia Jose Carlos , Mittal Abhenil , Tamimi Faris , Amir Eitan 
Published: August 2022

Abstract
Background: Little is known about the impact of control group therapy on clinical benefit scales such as American Society of Clinical Oncology Value Framework (ASCO-VF), European Society for Medical Oncology Magnitude Clinical Benefit Scale (ESMO-MCBS), National Comprehensive Cancer Network (NCCN) Evidence Blocks and ASCO Cancer Research Committee (ASCO-CRC). Methods: We searched Drugs@FDA to identify cancer drugs approved between January 2012 and December 2021 based on randomized trials (RCTs). Definition of substantial clinical benefit was based on recommendations for each scale. Associations between characteristics of control group therapy and clinical benefit were explored using logistic regression. Results: RCTs with a control group of active treatment plus placebo were associated with significantly lower odds of substantial benefit with ESMO-MCBS (OR:0.27, P=.003) and ASCO-VF (OR:0.30, P=.008) but not with NCCN Evidence Blocks or ASCO-CRC. This effect was attenuated and lost statistical significance without adjustment for quality of life (QoL) and/or toxicity (ESMO-MCBS OR:0.50, P=.17; ASCO-VF OR:0.49, P=.11). Discussion: Clinical benefit scales can be sensitive to control group therapy. RCTs with substantial overlap between experimental and control therapy showed lower magnitude of clinical benefit using ESMO-MCBS and ASCO-VF scales; possibly due to differences in the weighting of QoL and toxicity between different frameworks.
Federal Job Guarantee as a Path for Ending Income Inequality and Promoting Business Sustainability
Authors: Zumaeta Jorge N. , Darity william 
Published: August 2022

Abstract
This paper expands on the benefits of the Federal Job Guarantee (FDG) and offers an exploration for financing the program (Paul, et Al., 2018). The FJG is a program that supplies a tangible and sustainable solution to break the cycle of long-term poverty in America by providing quality employment options for all, especially for the most financially vulnerable members of our society (Paul, et al, 2017, 2018) (Tcherneva, 2005, 2018). The program has three additional other benefits. First, it creates a counter-cyclical stabilizer that could smooth severe economic downturns (Palley, 2018) (Tcherneva, 2017), Second, it generates a skillful and competitive labor force due to active investment in skills development with the prospect of impacting a business's bottom line (Paul, et al, 2018) (Dunn, 2018), and third, it serves as a price floor for wages in the labor market (Paul, et Al., 2017). An efficient labor market creates a more efficient and productive business environment (Deming, 2017). In short, the FJG, if implemented conscientiously, efficiently, and strategically, has the potential of serving as a mechanism for moderating economic downswings and as a catalyst for igniting socio-economic development and equity, thereby contributing to a more productive and competitive labor force in support of business growth. Additionally, the COVID-19 Global Pandemic and economic crisis are offering an opportunity to rethink our tools to soften the business cycle swings (Hensher, 2020). The FJG can provide the safety net for the millions of people that have been left without employment during this crisis (Tcherneva, 2019, 2020). The FJG offers tangible and sensitive solutions for many Americans.JEL Classifications: D60, D63, D69, E62, J38, L38, L88, O22
Fused Lasso Logistic Matrix Regression Method for Multi- Source Data Fusion of Raman Spectroscopy
Authors: Xu Xiang , Cao Yiyun , Xiao Wentao , Zhang Zhengyong 
Published: August 2022

Abstract
Raman spectrometer has a broad application prospect in the identification of dairy products quality. The diversity of measuring instruments makes the spectral data present multi-source. Multi-source data can provide more accurate information than single-source data by supporting, supplementing and correcting each other. How to fuse spectral data from different sources is a valuable research problem. In this paper, the Fused Lasso Logistic Matrix Regression (FLLMR) model is proposed for multi-source spectral data fusion, and a fast-iterative algorithm is designed by using Auxiliary Problem Principle (APP). The iterative process of the algorithm has a simple closed form. In order to verify the validity of the model and algorithm, we used 10 spectrometers to collect Raman spectral data of two kinds of dairy products respectively. Then, we used FLLMR method to perform fusion and discriminant analysis on the collected data. Experimental results show that the FLLMR method can effectively process multi-source Raman spectral data, and the model results have good interpretation. On the other hand, experiments verify the effectiveness of the proposed algorithm.
A safe ex-vivo application of an autonomous medical robot with AI
Authors: Cop Ruben , Meer Wicher van der , Carloni Raffaella , Ren Yijin , Gulabivala Kishor , Sluis Luc van der 
Published: August 2022

Abstract
While most robot platforms in clinical settings are still controlled by a human operator, synergy of robot technology and artificial intelligence will eventually enable fully autonomous surgical robots. Here we show such a combined robot system where neural networks ensure safety for the patient while increasing the accuracy of the system. The system is able to autonomously remove hard material and was tested by drilling a pre-operatively planned access cavity in a predetermined tooth in a phantom head. The performance of the system was validated by a deviation analysis of 56 teeth prepared by the robot system with a Micro CT scanner. The safety level of the system and the response time to potentially hazardous situations was also assessed. The results show that the system is capable of drilling openings in a consistent manner (trueness: 0.34mm, precision: 0.2mm). The neural networks allow the system to detect external forces and visual occlusion and show excellent detection of hazardous situations). The performance of the system surpasses human performance and meets clinical standards.
Hepatic artery intervention combined with immune-targeted therapy is superior to sequential therapy in BCLC-C hepatocellular carcinoma
Authors: Dong Hanzhi , Jian Yan , Peng Zhiqiang , Wang Meijian , Cheng Na , Liu Fangfang , Zhang Qi , Zhang Wenfeng 
Published: August 2022

Abstract
Background: Hepatic artery intervention combined with immunotarget therapy exerts excellent disease control and prolongs survival. However, the arrangement of hepatic artery intervention and systemic therapy confuses clinical decisions.Methods: A two-center, retrospective clinical study was approved by the Institutional Ethics Committee. From December 2018 to February 2022, patients with BCLC-C HCC who received targeted therapy plus PD-1 inhibitors with or without hepatic artery intervention were included. According to the treatment mode, the patients were assigned to three groups: initial hepatic artery intervention combined with immunotarget therapy, immunotarget therapy sequential hepatic artery interventional therapy, and immunotarget therapy only. The survival, response, and adverse events were compared among the three groups. Subgroup analysis and univariate and multivariate prognostic analyses were also evaluated.Results: The median follow-up time was 18.3 months (95% CI 16.7 to 20.0 months). A total of 163 patients with BCLC-C stage HCC were assigned to three groups: initial hepatic artery intervention plus PD-1 inhibitors plus targeted therapy (HPT, n=66), PD-1 inhibitors plus targeted therapy followed by hepatic artery intervention (PTH, n=56) and PD-1 inhibitors plus targeted therapy (PT, n=41). The median progression-free survival was 8.37 months (95% CI 6.35-10.39) with HPT versus 5.3 months (95% CI 3.48-7.12) with PTH versus 6.33 months (95% CI 3.75-8.92) with PT. The progression-free survival of the HPT group was better than that of the PTH group (HR 0.66, 95% CI 0.45-0.97, p=0.027) and PT group (HR 0.60, 95% CI 0.39-0.92, p=0.01). The median overall survival was 14.6 months (95% CI 10.6-18.7) with HPT, 10.0 months (95% CI 8.2-11.8) with PTH and 11.3 months (95% CI 8.3-14.3) with PT. The 1-year OS rates in the HPT, PTH and PT groups were 50%, 33.9%, and 34.1%, respectively. Overall survival was significantly longer in the HTP group than in the PT group (HR 0.60, 95% CI 0.361-0.996, p=0.032). Compared with the PTH group, the overall survival of the HTP group had a prolonged survival trend (HR 0.66, 95% CI 0.416-1.032, p=0.059). All treatment modalities were deemed equally safe. Multivariate analysis suggested that the mode of treatment, albumin level, Child‒Pugh grade and hepatectomy history were independent prognostic factors for BCLC-C HCC patients.Conclusions: Initial hepatic artery intervention combined with immunotarget therapy gained survival benefits with tolerable side effects compared with immunotarget sequential hepatic artery intervention and immunotarget therapy alone. Multivariate analysis suggested that liver reserve function was closely correlated with prognosis.
Morphometric Study of Sacral Hiatus in Dry Adult Human Sacra: Its Clinical Relevance in Caudal Epidural Block
Authors: Yadav Nisha , Jasuja Vishal 
Published: August 2022

Abstract
INTRODUCTION:
Correct localization of the sacral hiatus is essential for administering a successful caudal epidural block. The present study was undertaken to find out the anatomical variations of sacral hiatus by metrical method, so that it could help anaesthesiologists in the clinical field.
MATERIALS AND METHODS
Study was performed on 140 (83 male and 57 female) adult human sacra of known sex. Various parameters of sacrum studied were as follows; the shape of hiatus, length of sacral hiatus, transverse width at the base and anteroposterior diameter at the level of apex. For each parameter, the mean value (calculated in mm), standard deviation, range and percentage of bones identified correctly were calculated.
RESULTS
Various shapes of sacral hiatuses were observed, including inverted ‘U’ in 73 (52.14%), inverted ‘V’ in 33 (23.57%), irregular in 10 (7.14%), elongated in 10 (7.14%) and dumbbell shaped in 12 (8.57%). Absent sacral hiatus was observed in 2 (1.43%) specimens. The mean value for length of sacral hiatus from apex to midpoint of base was found to be 23.26 mm in males and 22.38 mm in females. However, the parameter was found to be statistically not significant. The mean value for transverse width at base of hiatus was found to be 14.19 mm in males and 13.54 mm in females. The mean value for anteroposterior diameter of sacral canal at apex was found to be 4.57 mm in males and 4.32 mm in females. Both the above parameters were found to be statistically not significant.
SUMMARY AND CONCLUSION:
The anatomical knowledge of sacral hiatus and its variations are important in caudal epidural anaesthesia, and it may improve the success rate of caudal epidural anaesthesia.
Associations between parenteral energy/amino acids and clinical outcomes in long-term fasting ICU patients: A retrospective cohort study using a medical claims database
Authors: Yasuda Hideto , Horikoshi Yuri , Kamoshita Satoru , Kuroda Akiyoshi , Moriya Takashi 
Published: August 2022

Abstract

BackgroundThe aim of this study was to clarify the associations between energy/amino acid doses and clinical outcomes for intensive care unit (ICU) patients receiving parenteral nutrition.MethodsICU patients aged ≥ 18, receiving mechanical ventilation, and fasting for > 7 days were identified in a medical claims database between January 2010 and June 2020 and were compared in 3 different ways by: (1) mean daily energy dose (Low-calorie < 10 kcal/kg/day; Middle-calorie ≥ 10, < 20 kcal/kg/day; High-calorie, ≥ 20 kcal/kg/day); (2) mean daily amino acid dose (Low-amino acid < 0.3 g/kg/day; Middle-amino acid ≥ 0.3, < 0.6 g/kg/day; High-amino acid ≥ 0.6 g/kg/day); and (3) mean daily energy/amino acid dose combinations. The primary endpoint was in-hospital mortality, and secondary endpoints were hospital readmission and length of stay. Multivariate logistic or multiple regression analyses were performed to calculate adjusted odds ratios (AOR) or adjusted regression coefficients and 95% confidence intervals (CI). ResultsA total of 20,773 patients were included. With a reference of Low-calorie, AOR (95% CI) of in-hospital mortality was lower for Middle-calorie (0.85 [0.78-0.92]). With a reference of Low-amino acid, it was lower for High-amino acid (0.69 [0.63-0.76]). With a reference of Middle-calorie/High-amino acid, it was highest in High-calorie/Low-amino acid (2.25 [1.76-2.87]) and High-calorie/Middle-amino acid (1.68 [1.36-2.08]), and did not differ in Low-calorie/High-amino acid (1.10 [0.78-1.56]) and High-calorie/High-amino acid (1.16 [0.99-1.35]).ConclusionsIn ICU patients receiving only parenteral nutrition, in-hospital mortality was lower when at least 0.6 g/kg/day-amino acid is prescribed regardless of the amount of prescribed calories. Attention on amino acid doses is needed in such patients.Trial registrationThe study was conducted after being registered in the clinical study registration system in the University hospital Medical Information Network (UMIN) clinical trial registry (Japan) (UMIN000042607). Retrospectively registered December 1, 2020. Available at: https://upload.umin.ac.jp/cgi-open bin/ctr_e/ctr_view.cgi?recptno=R000048553
Simplified cryopreservation of sperm in Grey mullet Mugil cephalus: A robust method for wide adoption
Authors: Ramachandran Balamurugan , Kumbha Shekar Babu , Saini Bharat , Jha Natwar , Prabhakar Varsha , Venkatesan Arul 
Published: August 2022

Abstract
In this study, we developed a simple and robust method of cryopreservation of sperm in
Mugil cephalus. A series of experiments were conducted to develop a simplified method by changing the extender, cryoprotectant and freezing height above the liquid nitrogen (LN2) surface. Fresh sperm were diluted 1:1 in a cryomedium (cryomedium = extender + cryoprotectant) containing cryoprotective agents (CPAs) namely, propylene glycol (PG), methanol (MeOH), glycerol (GLY), ethylene glycol (EG), dimethylsulfoxide (DMSO) and dimethylacetamide (DMA). The final concentration of CPAs in cryomedium was 5% and 10% (v/v). The cryovials (2.0 mL) were loaded with diluted samples, fixed in cryo canes, and frozen at 4, 6, 8, 10 and 12 cm above the LN2 surface and also by vitrification. After 7, 30 and 180 days of storage in LN2 (-196 °C), the sperm was thawed at 30 °C for 90-120 s and their quality was evaluated. Among the experimented factors, sperm diluted in cryomedium composed of 0.3 M glucose combined with 10% EG, frozen at 4 cm above the LN2 surface recorded significantly (P < 0.05) highest post-thaw motility (73 ± 2%) and (71 ± 1%) viability respectively. However, no significant (P > 0.05) differences were observed in sperm quality at different storage days. Thus, the results of the study revealed that using this simplified method of cryopreservation high-quality post-thaw sperm can be obtained. Besides, it is expected that this method can be successfully adoptable at hatchery, farm and on-site cryopreservation of sperm in grey mullet.
The role of imaging in the diagnosis of acute appendicitis during the COVID- 19 pandemic: a retrospective cohort study
Authors: Perrotta Gerardo , Geropoulos Georgios , Bhan Chetan 
Published: August 2022

Abstract
Purpose: Acute appendicitis is one of the most common general surgical emergencies worldwide, however its diagnosis remains challenging, with a high proportion of negative appendicectomies. The purpose of this study was to investigate the benefit of routine use of pre-operative imaging for the evaluation of suspected appendicitis.Methods: This retrospective cohort study included all cases of appendicectomies performed for suspected acute appendicitis during the first and second peaks of the COVID-19 pandemic, between March 2020 and February 2021. The control group included all cases of appendicectomies performed for suspected acute appendicitis in the previous 12 months (March 2019-February 2020).Results: 104 patients underwent appendicectomy in the study group, compared to 209 in the control group, with similar gender distribution but a significantly higher mean age in the study group (37.51 vs 31.92, p < 0.05). The two groups had similar rates of perforation and similar mean white cell count, but mean CRP was higher in the study group (86.84 mg/L vs 48.33 mg/L, p < 0.05). Imaging was used in 80.77% of the patients in the study group, compared to 61.72% in the control group (p < 0.05), with 55.77% of patients in the study group undergoing CT scans. Despite this, the difference in NAR in the two groups was not statistically significant (11.54% vs 15.79%, p = 0.320).Conclusion: The increase in the use of imaging for the diagnosis of acute appendicitis during the COVID-19 pandemic did not lead to a significantly lower Negative Appendicectomy Rate.