bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Kenikir (Cosmos caudatus Kunth.) Leaf Extract on Duodenal Epithelial Damage of Aspirin Induced Male White Rats (Rattus norvegicus)
Authors: Alfina Siti , Febriani Husnarika , Syukriah Syukriah 
Published: June 2022

Aspirin or acetylsalicylic acid is one of the most common types of anti-inflammatory drugs used by people to relieve pain and inflammation. However, aspirin consumption can cause damage to the duodenal mucosal epithelium because it is acidic and inhibits the production of prostaglandins that are important in maintaining the mucosa. Duodenal damage due to aspirin consumption can be repaired using natural ingredients from plants with antioxidant and anti-ulcer effects, one of which is kenikir (Cosmos caudatus Kunth.) leaves. This study aims to determine the effectiveness of kenikir leaf extract against aspirin-induced histopathology and histomorphometry of the duodenum of male white rats. The research design used a completely randomized design (CRD) with 5 treatments and 5 replications. The treatments consisted of a normal group (feed and drink ad libitum), an aspirin group (induction of aspirin 200 mg/kgBW), and a treatment group with kenikir leaf extract at a dose of 700 mg/kgBW, 800 mg/kgBW, and 900 mg/kgBW. Preparation of histopathological preparations of the duodenum used the paraffin method with Hematoxylin-Eosin staining. Data were analyzed using one-way ANOVA and Duncan's follow-up test. The results of the histopathology study showed a significant difference (p<0.05) on the integrity score of duodenal mucosal epithelial cells. Histomorphometry had a significant effect on the height villi, basal width, apical width, and villous area (p<0.05). It can be concluded that administration of kenikir leaf extract at a dose of 900 mg/kgBW was most effective in improving the histopathology and duodenal histomorphometry of aspirin-induced male white rats.
Keywords: aspirin, duodenum, kenikir (Cosmos caudatus Kunth.)
Comparison of the efficacies of 1.0 and 1.5 mm silicone tubes for the treatment of nasolacrimal duct obstruction
Authors: Nakamura Jutaro , Kamao Tomoyuki , Mitani Arisa , Mizuki Nobuhisa , Shiraishi Atsushi 
Published: June 2022

Abstract

This retrospective observational study analyzed the postoperative outcomes of bicanalicular intubation using different diameters of tube stents for treating postsaccal nasolacrimal duct obstruction. A total of 130 patients diagnosed with postsaccal obstruction who underwent endoscopic-assisted silicone tube intubation were included in the study. Patients intubated with a 1.5-mm large-diameter tube were designated as the LD group, and those with a 1.0-mm normal-diameter tube were designated as the ND group. The patency rates of the two groups at 1 year after tube removal were compared using the Kaplan–Meier curve and restricted mean survival time (RMST) method with τ = 365 days. Results demonstrated that the recurrence rate after tube removal was significantly lower in the LD group as compared with the ND group (p = 0.001). The patency rates at 1 year after removal in the LD and ND group were 85.7% (95% confidence interval [CI]: 75.4, 91.9) and 73.9% (95% CI: 61.7, 82.8), respectively. When comparing the patency rates by the RMST method at τ = 365 days, the RMST difference, RMST ratio, and RMTL ratio were higher in the LD group at p = 0.045, 0.052, and 0.046, respectively.
Broad fault zones enable deep fluid transport and limit earthquake magnitudes
Authors: Leptokaropoulos Konstantinos , Rychert Catherine , Harmon Nicholas , Schlaphorst David , Grevemeyer Ingo , Kendall John-Michael , Singh Satish 
Published: June 2022

Abstract
Constraining the controlling factors of fault rupture is fundamental to understanding the earthquake cycle. Fluids can influence earthquake locations and magnitudes, although the exact pathways of fluids through the lithosphere are not well-known. Ocean transform faults are an ideal laboratory to study the factors controlling fault ruptures and fluid pathways given their relative simplicity. Here, we analyse seismicity recorded by the Passive Imaging of the Lithosphere-Asthenosphere Boundary (PI-LAB) experiment, centred around the Chain Fracture Zone. We find that earthquakes beneath mapped morphological transpressional features occur deeper than the brittle-ductile transition predicted by simple thermal models but elsewhere occur shallower. These features are characterised by multiple parallel fault segments and step overs, high b-values, gaps in large historical earthquakes, and seismic velocity structures consistent with hydrothermal alteration. This suggests that broader fault damage zones preferentially facilitate fluid transport into the lithosphere. Although this cools the mantle, it also reduces the potential for large earthquakes at punctuated locations (barriers). These barriers divide the transform into asperity segments that are shorter, thereby limiting the earthquake magnitudes in these regions.
The International Platform of Registered Systematic Review and Meta-analysis Protocols (INPLASY®) at two years: an analysis of 3,082 registered protocols on inplasy.com, platform features, and website statistics
Authors: Canellas João Vitor dos Santos , Ritto Fabio Gamboa , Rodolico Alessandro , Aguglia Eugenio , Fernandes Gustavo Vicentis de Oliveira , Figueredo Carlos Marcelo da Silva , Vettore Mario Vianna 
Published: June 2022

Abstract
Background
INPLASY® is an international platform for registration of systematic review and meta-analysis protocols launched in March 2020. INPLASY® provides an online database where the protocols are maintained as a permanent public record and can be accessed on the website (www.inplasy.com).
Methods
We described the database features and registered information of all records published since the launch of the registry up to March 31st, 2022. Additionally, the website statistics dataset was analysed to explore user experience and promote data transparency.
Results
A total of 3082 records were registered in INPLASY®, and more than 91% of the protocols were published within 24 hours. Most submissions were from China, followed by Portugal, Brazil, Taiwan, and Spain. INPLASY® website received a total of 240,855 page views from 37,647 visitors during the first two years. These accesses were from 139 countries worldwide. Most of the accesses were from China, followed by The United States, Brazil, and Germany. The review status ‘‘completed and published’’ was observed in 323 protocols, and these studies were published in 156 different scientific peer-reviewed journals. The INPLASY® features included: (i) INPLASY® identifier, a unique protocol number; (ii) DOI number, the URL of the protocol linked to a specific DOI; (iii) ORCID update, INPLASY® updates the authors' ORCID page including their protocol automatically; and (iv) search tools, the protocols are freely accessible on www.inplasy.com.
Conclusions
The INPLASY® has several practical and useful features that should be considered when planning the registration of a systematic review protocol. Furthermore, the sharp increase in the number of protocols registered in INPLASY® in the first two years and the database statistics demonstrate that INPLASY® has become an important source of systematic review protocols. Therefore, authors should access INPLASY® before planning a future review study, either to avoid unintended duplication of efforts, or to obtain registration in a timely manner.
Quality of Life Among Type II Diabetes Mellitus Patients at Kamuzu Central Hospital in Lilongwe, Malawi: A Mixed-Method Study
Authors: Chisalunda Alinafe , Ng’ambi Wingston , Tarimo Nesto , Banda Ndaziona Peter Kwanjo , Muula Adamson Sinjani , Kumwenda Johnstone , Nyondo-Mipando Alinane Linda 
Published: June 2022

Abstract
Background
Type II diabetes mellitus (T2DM) significantly impacts quality of life (QoL) yet data on quality of life among these patients in Malawi are lacking. This study was conducted to assess QoL among patients with T2DM.
Methods
A mixed-method cross-section study was conducted at Kamuzu Central Hospital (KCH), Lilongwe, Malawi. A systematic sampling method was used for quantitative data and purposive sampling was used for qualitative data. A modified diabetes quality of life (MDQoL)-17 questionnaire was used for quantitative data while in-depth interviews and diary methods were used for qualitative data. Demographic data were summarized using descriptive statistics and inferential statistics using t-test and ANOVA. Thematic analysis was utilized to analyze qualitative data. Ethical approval was obtained from the College of Medicine Research and Ethics Committee (CoMREC) reference number P.09.20.3122.
Results
A sample of 339 participants (mean age 50.3 ± 15.5) was recruited. Overall, the mean QoL score was moderate (63.91 ± 19.54). Those with tertiary education and those on health insurance had better QoL (QoL 73.8, C.I. 68.56–79.04, p-value 0.005), (QoL 76.71, C.I. 69.22–84.19, p-value 0.005) respectively compared to those with lower education and those without health insurance. Furthermore, absence of comorbidities was associated with having better QoL (QoL 71.18, C.I. 66.69–75.67, p-value < 0.0001). Qualitatively, participants referred to QoL as an absence of disease and leading an independent life. T2DM was associated with patients’ health status, increased stress levels and loss of independence. There were QoL-promoting factors among T2DM patients such as diabetes health talks, having a supportive family and following hospital advice. Inhibiting factors include drug shortages, societal perceptions, sedentary lifestyle, stress, and despising hospital advice.
Conclusions
Overall QoL in patients with T2DM receiving treatment at KCH is moderate. QoL of patients with T2DM is influenced by interrelated factors which requires multidisciplinary team care to optimize the QoL among these patients. Health workers need to adopt a holistic approach when treating patients with T2DM, such as managing comorbidities and including assessment of QoL, behavioral change measures like physical exercises, and a healthy diet. The government and various stakeholders need to promote mandatory national health insurance which improve health status.
Psychological resilience factors and their association with weekly
stressor reactivity during the COVID-19 outbreak in Europe
Authors: Bögemann Sophie , Puhlmann Lara , Wackerhagen Carolin , Zerban Matthias , Riepenhausen Antje , Köber Göran , Yuen Kenneth , Pooseh Shakoor , Marciniak Marta , Reppmann Zala , Uściƚko Aleksandra , Weermeijer Jeroen , Lenferink Dionne , Mituniewicz Julian , Robak Natalia , Donner Nina , Mestdagh Merijn , Verdonck Stijn , Dick Rolf van , Kleim Birgit , Lieb Klaus , Leeuwen Judith van , Kobylinska Dorota , Myin-Germeys Inez , Walter Henrik , Tüscher Oliver , Hermans Erno , Veer Ilya , Kalisch Raffael 
Published: June 2022

Abstract
Recently, cross-sectional relationships between psycho-social resilience factors (RFs) and resilience, operationalized as an outcome of low reactivity of mental health to stressor exposure (low ‘stressor reactivity’) during the first wave of the COVID-19 pandemic, were reported. Extending these findings, we here examine prospective relationships and weekly dynamics between the same RFs and stressor reactivity in a longitudinal sample during the aftermath of the first wave in several European countries. Over five weeks of app-based assessments, participants weekly reported stressor exposure, mental health problems, RFs, and demographic data, in one of six different languages. As (partly) preregistered, hypotheses were tested cross-sectionally at baseline (N=558) and longitudinally (N=200), using mixed effects models and mediation analyses. RFs at baseline, including positive appraisal style, optimism, self-efficacy, perceived good stress recovery, and perceived social support, were negatively associated with stressor reactivity (SR) scores, not only cross-sectionally (baseline SR scores) but also prospectively (average SR scores across subsequent weeks). In both analyses, positive appraisal style mediated the effects of perceived social support on SR. In the analyses of weekly RF-SR dynamics, RFs positive appraisal (of stressors generally and specifically of the Corona crisis) and general self-efficacy were negatively associated with SR in a contemporaneous, but not lagged fashion. We identify psychological RFs which prospectively predict resilience and co-fluctuate with weekly stressor reactivity within individuals. The prospective results endorse that the previously reported RF-SR associations do not exclusively reflect mood-congruency or other temporal bias effects. We further confirm an important role for positive appraisal in resilience.
A touchless user interface based on a near-infrared sensitive transparent optical imager using printed Cu grid electrodes.
Authors: Kamijo Takeshi , Breemen Albert van , Ma Xiao , Shanmugam Santhosh , Bel Thijs , de Haas Gerard , Peeters Bart , Petre Razvan , Tordera Daniel , Verbeek Roy , Akkerman Hylke , Hagelsieb Luis , de Roose Florian , Lieberman Itai , Janssen René , Meulenkamp Eric A. , Kronemeijer Auke , Gelinck Gerwin 
Published: June 2022

Abstract
Touchless technology based on user interaction modes such as voice or gestures is paving the way for tomorrow’s digital ecosystems, accelerated by hygiene requirements resulting from the COVID-19 pandemic. Gesture-based touchless user interfaces typically use near-infrared (NIR) cameras. The applicability of these systems is hampered by their limitations in field of view and their calibration requirements for high accuracy. Here, we show a novel touchless user interface based on a large-area visually transparent NIR-sensitive 16 × 16 organic photodetector (OPD) array that can be used on top of a display as a touchless user interface. Optical transparency is realized by implementing a printed copper (Cu) grid as a bottom transparent conductive electrode (TCE) and an array of patterned OPD subpixels. Electro-optical modelling enabled an optimal image sensor design that resulted in a high photodetectivity of ca. 1012 Jones at 850 nm and high visible-light transmittance of 70%. We demonstrate that our imager can be used as a penlight- and gesture controlled touchless user interface when combined with a commercial display.
A Posture Detection Method for Augmented Reality Aided Assembly Based on YOLO-6D
Authors: Zhang Liping , XU Feng , Liu Yu , Zhang Dan , Gui Liang , Zuo Dunwen 
Published: June 2022

Abstract
The assembly of small batch electrical and mechanical products still relies on manual operation, with the problems of high rechecking time and low assembly efficiency and quality. The augmented reality technology can be used to assist assembly to improve efficiency. In view of the high professionalism, labor and time cost for the traditional posture detection method, a posture detection method is proposed to match the assembly posture by pre-calibrating the assembly posture template. YOLO-6D deep learning network is brought in to increase the accuracy of virtual information tracking registration. And the detection from both translation and rotation perspectives is designed to enhance the adaptability to different assembly tasks. For the generation of training datasets, a weighted sampling method based on part features is proposed to optimize the accuracy of position estimation with the limited training samples. Taking the assembly process of typical electronic products as an example, the developed augmented reality aided assembly system is used to boost the assembly efficiency of assembly operators. It is illustrated that the proposed positional detection method is effective in registering virtual assembly guidance information in real scenarios and can be applied to augmented reality assembly guidance of products.
Toll-like Receptor Agonists Enhance HIV-specific T Cell Response Mediated by Plasmacytoid Dendritic Cells in Diverse HIV-1 Disease Progression Phenotypes
Authors: Ruiz-Mateos Ezequiel , Jimenez-Leon Maria Reyes , Gasca-Capote Carmen , Tarancon-Diez Laura , Dominguez-Molina Beatriz , Lopez-Verdugo Macarena , Ritraj Ryan , Alvarez-Rios Ana Isabel , Vitallé Joana , Bachiller Sara , Pérez-Gómez Alberto , Espinosa Nuria , Roca-Oporto Cristina , Benhnia Mohamed Rafii-El-Idrissi , Gutierrez-Valencia Alicia , López-Cortés Luis Fernando 
Published: June 2022

Abstract
Plasmacytoid dendritic cells (pDCs) sense viral and bacterial products through Toll-like receptor (TLR)-7 and -9 and translate this sensing in Interferon-α (IFN-α) production and T cell polarization. These cells are considered a link between innate and adaptive immunity, inducing and maintaining antigen-specific T cell responses and contributing to the control and eventually to the chronic immune activation and disease progression in HIV-1 infection scenario. The understanding of the mechanisms involved in pDCs stimulation may contribute to immunotherapeutic strategies aiming to decrease HIV-1 reservoir. The objective of the present study was to characterize the immunomodulatory effects of TLR agonist stimulations through a pDC/T cell coculture in different HIV-1 disease progression phenotypes and healthy donors (HD). pDCs were previously stimulated with AT-2-HIV-1, CpGA, CpGC and GS9620. After coculture with autologous CD4 or CD8 T cells we observed an increase of pDCs activation markers levels, interferon related genes, HIV-1 restriction factors and cytokines levels. This pDCs coordinate activation was prominent with CpG-C and GS9620 and induced an increase of HIV-specific T cell response. This pDCs dependent HIV-1 specific T-cell response was associated with the upregulation of HIV-1 restriction factors and IFN-α production. Interestingly, pDCs activation in people on ART was similar to that found in people that spontaneously control the virus. These results shed light on the mechanisms associated with TLR-specific pDCs stimulation associated with T cell polarization for eliciting antiviral response which is essential for HIV eradication strategies.
Humoral Immune Response to Inactivated COVID-19 Vaccination at the 3rd Month among People Living with HIV
Authors: Wu Songjie , Zou Shi , Ming Fangzhao , Wu Mengmeng , Guo Wei , Xing Zhongyuan , Zhang Zhiyue , Liu Jinli , Tang Weiming , Liang Ke 
Published: June 2022

Abstract
Background: Research on the immune response to inactivated COVID-19 vaccination among people living with HIV (PLWH) is limited, especially among those with low CD4+ T lymphocyte (CD4 cell) count. This cross-sectional study aimed to assess the humoral immune response to inactivated COVID-19 vaccination among PLWH compared to HIV negative controls (HNC) and to determine the impact of CD4 cell count on vaccine response among PLWH.Methods: The neutralizing antibodies (nAbs) and the specific IgM and IgG-binding antibody responses to the inactivated COVID-19 vaccine at the third month after the second dose of inactivated COVID-19 vaccination were measured among 138 PLWH and 35 HNC. Multivariable logistic regression and multiple linear regression models were conducted to identify factors associated with the seroconversion rate of antibodies and the magnitude of anti-SARS-CoV-2 antibody titers, respectively.Results: At the end of the third month after two doses of vaccination, the seroconversion rates of IgG were comparable between PLWH (8.7%; 95%CI, 3.9-13.5%) and HNC (11.4%; 95%CI, 0.3-22.5%), respectively. The median titers and seroconversion rate of nAbs among PLWH were 0.57 (IQR: 0.30-1.11) log10 BAU/mL and 29.0% (95%CI: 21.3-36.8%), respectively, both lower than those in HNC (P＜0.05). After adjusting for age, sex, comorbidities, and CD4 cell count, the titers and seroconversion rate of nAbs were comparable between PLWH and HNC (P＞0.05). Multivariable regression analyses showed that CD4 cell count＜200 /μL was independently associated with lower titers and seroconversion rate of nAbs among PLWH (P＜0.05). A positive correlation was observed between the CD4 cell count and nAbs titers in PLWH (Spearman'sρ=0.25, P=0.034). Conclusion: Our study concluded that the immune response to inactivated COVID-19 vaccination among PLWH was independently associated with CD4 cell count, PLWH with lower CD4 cell count showed a weaker humoral immune response, especially those with CD4 cell count＜200 /μL. This finding suggests that expanding COVID-19 vaccination coverage among PLWH is impendency. In addition, aggressive ART should be carried out for PLWH, especially for those with low CD4 cell count, to improve the immune response to vaccines.
Prevalence and Factors Associated with Hypothyroidism in Children with Sickle Cell Anemia Aged 6 Months -17 Years Attending the Sickle Cell Clinic, Mulago Hospital, Uganda; A cross- sectional study
Authors: Kaudha Gloria , Piloya Thereza , Musiime Victor , Kuteesa Mary Goretty , Namugerwa Shamimu , Owomugisha Gloria , Wachepa Stella Alinafe , Lubwama Sanyu Kirabo , Kiguli Sarah , Tumwine James K 
Published: June 2022

Abstract
Background
Sickle cell anemia (SCA) leads to chronic end organ damage including the thyroid gland. This is postulated to be due to recurrent hemolysis leading to iron overload, vaso - occlusive crises, micro-vasculature obstruction due to red cell entrapment and frequent transfusions. Hypothyroidism has been reported at a prevalence of 6% in children and adolescents with SCA. Hypothyroidism may affect brain and physical development. In this study, we determined the prevalence and factors associated with hypothyroidism among children with SCA attending the Sickle Cell Clinic (SCC), Mulago hospital in Uganda.
Methods
A cross-sectional study was conducted among children aged 6 months − 17 years with a confirmed diagnosis of SCA, no prior diagnosis of hypothyroidism and in steady state attending the SCC in Mulago hospital. Data was collected using a structured questionnaire and a blood sample obtained was used to measure thyroid stimulating hormone (TSH) and free thyroxine (FT4). Clinical hypothyroidism was defined as TSH level > 9 mIU/L and free T4 < 0.6 ng/dL [primary hypothyroidism] or normal or low TSH level and free T4 < 0.6 ng/dL [central hypothyroidism]. Sub-clinical hypothyroidism was TSH ranging between 4.5 and10 mIU/L with normal age appropriate free T4 levels. Multivariate logistic regression models were constructed to determine the factors associated with hypothyroidism. A p < 0.05 was considered significant.
Results
Of the 332 children enrolled, 50.3% (167/332) were female; median age (IQR) was 6 (3–10) years. Sixty (18.1%) participants had hypothyroidism (95% CI: 14.3 — 22.6) and all the 60 had sub-clinical hypothyroidism. Factors associated with hypothyroidism included constipation [aOR: 3.1, 95% CI:1.0 — 9.0, p = 0.043] and male sex [aOR:2.0, 95% CI:1.1— 3.5, p = 0.025].
Conclusions
Approximately 1 in 5 children (18.1%) had hypothyroidism. Males and children who presented with constipation were more likely to have hypothyroidism. This suggests that clinicians should screen all children with SCA who present with constipation for hypothyroidism and those found with hypothyroidism should be treated appropriately to improve their growth and quality of life.