bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authors: Amalia Maura Savika , Herawati Wiwik , Yani Edy 
Published: December 2022

Mangga (Mangifera indica L.) merupakan buah tropika yang diminati banyak orang sehingga dapat ditemukan di seluruh Indonesia. Mangga memiliki berbagai macam variasi morfologi. Keragaman ini terjadi karena adanya perkawinan silang, seleksi alam, pengaruh manusia, evolusi bahkan pengaruh lingkungan tiap lokasi Pengaruh lingkungan menyebabkan pertumbuhan daun, batang, akar, serta buahnya mengalami perbedaan pada setiap pohon. Penelitian bertujuan untuk mengetahui keanekaragaman kultivar mangga di Kabupaten Tangerang dan mengetahui hubungan kemiripan berdasarkan karakterteristik morfologi. Penelitian dilakukan di Kabupaten Tangerang dengan metode survey, dengan tehnik pengambilan sampel secara Purposive Sampling. Parameter yang diamati meliputi karakteristik morfologi batang, daun, buah dan biji. Data sampel mangga dianalisis dengan metode deskriptif. Sedang untuk mengetahui hubungan kemiripan dianalisis dengan MEGA X menggunakan metode UPGMA. Hasil penelitian dari empat kecamatan di Kabupaten Tangerang ditemukan 14 kultivar. Hubungan kemiripan berdasarkan 22 karakteristik morfologi menghasilkan fenogram yang terbagi kedalam 4 kelompok utama. M. indica L. ‘Madu’ dengan M. indica L. ‘Manalagi’ dan M. indica L. ‘Khiosaway’ dengan M. indica L. ‘Namdokmai’ mempunyai hubungan terdekat dengan indeks disimilaritas sebesar 0,182. M. indica L. ‘Chokanan’ dan M. indica L. ‘Gedong’ mempunyai hubungan terjauh dengan indeks disimilaritas sebesar 0,682.
SELECTIVE SURFACE HARDENING OF GEAR MECHANISM SHAFT BY ROBOTIC LASER 3D SYSTEM
Authors: Lesyk Dmytro , Hruska Matej , Sidun Karina , Dаnylеikо Oleksandr , Kyforenko Dmytro , Dzhemelinskyi Vitaliy 
Published: December 2022

A robot-based laser 3D hardening method is proposed as a finishing operation to increase the wear resistance of the metal end-products. The laser hardening process of the surface layer of the products by changing its structure is one of the most effective methods of selective surface hardening. Thermal hardening of metals and alloys by laser radiation is based on local heating of a surface area under the influence of radiation and subsequent cooling of this surface area at a supercritical speed due to heat removal into the inner layers of the metal. The used robot-based laser 3D system (FANUC industrial robot and SCANLAB scanning optics) allows processing the surfaces of any complexity and geometry, including the shafts of the gear mechanism of the seed drill. It was found that the development and improvement of the technological process of manufacturing steel shafts of the gearbox of the seed drill is an urgent technological problem due to the rapid retirement of the shaft, which leads to the expenditure of time and money for its replacement. The most heavily loaded sections of the shaft were pre-estimated using the SolidWorks Simulation software package. A high-power TruDisk 8002 solid-state disk laser with a maximum laser power of 8 kW and a wavelength of laser radiation of 1030 nm is used for high-quality laser surface treatment of the AISI 1066 steel shaft of the gear mechanism. The laser surface heat treatment was carried out using a constant power strategy (continuous mode), varying the laser power in the range of 1.35–2.25 kW. Based on the Fe-Mn two-component state diagram, the critical points of the temperature of complete austenization of the studied steel were previously predicted taking into account the chemical composition of the material. Additionally, the energy density values of the laser beam with a diameter of 1 mm on the working surface was estimated. The results showed that the surface hardness of the shaft was about 2.5 times higher compared to the untreated surface. The working ranges of laser heat treatment parameters of the gearbox shaft were established to increase the hardening intensity (100–150%) of the responsible areas.
Numerical simulation study on the deformation and failure of a gently inclined bedding slope: a case study of the Jinhaihu landslide in Guizhou, China
Authors: Liu Yongzhi , Shi Wenbing , Peng Xiongwu , Tao Tongwei , Wang Xiaoming 
Published: December 2022

Abstract
At approximately 7:00 p.m. on January 3, 2022, a bedding landslide (referred to as the Jinhaihu landslide in this paper) occurred in the Jinhaihu District of Bijie city, Guizhou Province, China, resulting in the death of 14 laborers. The catastrophic landslides induced by the geological conditions in the study area are incomprehensible and deserve an in-depth study of their genetic mechanisms. In this paper, a detailed field investigation was conducted on the Jinhaihu landslide, and the geological background of the landslide area and the characteristics of the landslide were well revealed. The slide zone and rock samples of the landslide site were obtained for physical and mechanical tests to further establish a coupled PFC/FLAC2D model of the landslide area and analyze the genetic mechanism of the Jinhaihu landslide using numerical simulation. The results indicate that the landslide area has been disturbed by long-term engineering, and a large amount of excavation at the foot of the slope has reduced the resistance of the landslide to slide downward, increased the damage to the slope, and provided space for the landslide to move. However, the excavation did not immediately initiate the landslide at the toe, and the claystone containing a large number of illite clay minerals (56.5%) gradually weakened with the infiltration of rainfall before the slope finally failed. The numerical simulation indicated that the excavation at the toe of the slope caused cracks at the crown, the softening of the claystone caused the sliding mass to be divided into blocks by the cracks, and then the sliding mass slid downward along the weak interlayer. First, the sliding mass toppled down and disintegrated at the front edge, and the rear of the sliding mass was tensile-fractured and failed. The movement of the rock blocks on the slide bed has the character of translation with almost no rotation. The evolution process of landslides is divided into four stages: the initial stage, fracture generation stage, softening stage and overall failure stage. The research results of this paper provide a reference for the risk evaluation and disaster prevention of the same category of landslides.
The role of integrins in atherosclerosis complicated with abdominal aortic aneurysm: A bioinformatics study
Authors: Ma Likang , Zhuang Xinghui , Chai Tianci , Wu Qingsong , Chen Liangwan , Qiu Zhihuang 
Published: December 2022

Abstract
Background
Increasingly, the shared risk factors and pathological processes of atherosclerosis and abdominal aortic aneurysm (AAA) are being recognized. However, the exact mechanism underlying the shared pathogenesis of atherosclerosis and AAA formation remains unclear.
Methods
The aim of our study was to identify the hub genes involved in the pathogenesis of atherosclerosis and AAA. Our analysis was based on two gene expression profiles for atherosclerosis (GSE28829) and AAA (GSE7084), downloaded from the Gene Expression Omnibus (GEO) database. Common differential genes were identified and an enrichment analysis of differential genes was conducted, with construction of protein-protein interaction networks, and identification of common hub genes and predicted transcription factors.
Results
The analysis identified 133 differentially expressed genes (116 upregulated and 17 downregulated), with the enrichment analysis identifying a potential important role of integrins and chemokines in the common immune and inflammatory responses of atherosclerosis and AAA. Regulation of the complement and coagulation cascades and regulation of the actin cytoskeleton were associated with both diseases, with 10 important hub genes identified: TYROBP, PTPRC, ITGB2, ITGAM, PLEK, CTSS, LY86, ITGAX, CCL4, and FCER1G.
Conclusions
Findings identified a common pathogenetic pathway between atherosclerosis and AAA, with integrin-related genes playing a significant role in both diseases. The common pathways and hub genes identified provide new insights into the shared mechanisms of these two diseases and can contribute to identifying new therapeutic targets and predicting the therapeutic effect of biological agents.
Treating Retinal Diseases by Optical Coherence Tomography Alone During COVID-19 Lockdown
Authors: Zhalka Fidaa El , atta dalila abu , Segal Ori , Moisseiev Elad 
Published: December 2022

Abstract
Purpose: To investigate the effects of managing retinal diseases by OCT exam alone due to COVID-19 pandemic on the treatment course of nAMD, DME and RVO patients, and compare it with real-life data.
Methods: A comparison between patients whose treatment was based on OCT alone during COVID-19 lockdown limitations and patients who visited the retina unit one year before.Recorded parameters included demographic data, visual acuity, OCT characteristics, number of anti VEGF injections to each eye before the COVID-19 visit, referral for intravitreal injections , number of injections and anti-VEGF drugs administered.
Results: A total of 165 eyes of 133 patients were included in the study group, and189 eyes of 145 patients in the control group. Both groups had similar baseline characteristics. Patients in the study group were referred to more anti VEGF injections than the control group (71.5%of patients vs 41.8 ,p<0.0001) Final visual acuity was better in the study group, but although this difference achieved statistical significance (p=0.037), it was a small change not likely to be clinically significant. The differences in CMT and volume changes were also not significant.
Conclusion: Treating patients with nAMD, CME due to RVO or DME with anti VEGF injections according to OCT imaging alone did not harm patients, and achieved satisfactory results. Adoption of this treatment regimen can be considered also for patients live in remote areas.
Analysis of inflammatory markers and electroencephalogram findings in paediatric patients with COVID-19: a single-centre study in Korea
Authors: Lee Sunho , Kim Kyung-Ran , Koo Chungmo 
Published: December 2022

Abstract
A big infectious wave overwhelmingly spread from February 2022 in South Korea after the COVID-19 outbreak was managed. Therefore, we analysed electroencephalogram (EEG) findings and serologic inflammatory markers in pediatric patients with COVID-19 by retrospectively reviewing medical records of 41 patients who visited Gyeongsang National University Changwon Hospital from March to May 2022 and were diagnosed with COVID-19; all serologic tests were performed within 24 hours after presenting with fever or seizure. The median patient age and average number of hospitalisation days were 3.6 (0.08–14.00) years and 3.71 (1.0–7.0) days, respectively. Interleukin-6 (IL-6) were elevated above the normal range in all patients (median value, 43.18 [7.0–190.0] pg/ml) and were higher among patients with seizures. Among 41 patients, 17 (41.5%) with a mean age of 5.4 years had higher complaints of seizures. Three patients had prolonged seizures for > 30 minutes and received intravenous lorazepam injections and eight had a complex type of febrile convulsion. Nine patients underwent EEG, and five showed abnormal findings in the initial EEG. In the linear regression model, serum IL-6 and blood lymphocyte counts were correlated with prolonged seizure duration. These findings underscore that several immune cascade-related serologic markers were elevated in children with COVID-19-related febrile seizures. We may assume that COVID-19 presents similarities and differences in the mechanisms that provoke seizures and fever in children.
Association of Coffee Consumption and Striatal Dopamine Transporter Binding in Patients with Parkinson’s Disease and Healthy Controls
Authors: Wang Chao , Zhou Cheng , Guo Tao , Jiaerken Yeerfan , Yang Siyu , Huang Peiyu , Xu Xiaojun , Zhang Minming 
Published: December 2022

Abstract
Emerging evidence indicates that coffee consumption significantly reduces the risk for developing Parkinson disease (PD). We aimed to investigate the role of chronic coffee consumption in nigrostriatal dopaminergic neurodegeneration using 123I-FP-CIT single photon emission computed tomography. Overall, 138 PD patients and 75 healthy controls (HC) were enrolled from the Parkinson’s Progression Markers Initiative cohort. Demographic, clinical and striatal dopamine transporter (DAT) characteristics were compared across subgroups, including current, ever and never coffee consumers in PD patients and HC, respectively. Furthermore, we included the factors that may have influenced the loss of nigrostriatal dopaminergic neurons in multiple linear regression analyses to identify significant contributing factors to striatal DAT binding in each striatal region. In PD patients, current consumers had significantly lower DAT binding in the bilateral caudate than ever/never consumers. In HC, current consumers had significantly lower DAT binding in the bilateral caudate and right putamen than ever/never consumers. Cups per day were negatively correlated with the left caudate DAT binding in current consumers of PD patients. In addition, multiple linear regression analyses showed current coffee consumption remained as an independent predictor of a decrease in striatal DAT binding. Striatal DAT downregulation caused by chronic effects of caffeine may provide evidence for the favorable implication of caffeine to PD pathologies. Furthermore, our study firstly suggests that the chronic effects of caffeine on striatal DAT may fade and disappear after quitting coffee.
Presence of and hospital resource utilization for comorbid ventricular septal defects in pediatric patients: A cross-sectional study in Shanghai, China
Authors: Huang Xiaoxu , Zhang Peipei , Yang Yan , Lu Sheng , Chen Ning , Wang Zhaoxin , Chen Chen , Shi Jianwei , Sun Wanju 
Published: December 2022

Abstract
Objectives
To describe the characteristics of high-incidence comorbidity combinations of pediatric ventricular septal defect (VSD) among inpatients in Shanghai, China.
Methods
In total, 5,994 inpatient pediatric VSD cases with ICD-10-based diagnoses were retrospectively studied. The top combinations and influencing factors associated with comorbidities were analyzed by the chi-squared test.
Results
Patients were predominantly aged 0–1 year (50.47%), had one admission (90.89%), and had surgery once (37.14%) or twice (38.71%). Major comorbidities were cardiovascular and respiratory. VSD + atrial septal defect (ASD) (14.58%), VSD + ASD + secondary pulmonary hypertension (PH) (4.75%) and VSD + ASD + patent ductus arteriosus (PDA) + secondary PH (0.67%) affected the most patients in each comorbidity group. Other top comorbidity groups included VSD + patent foramen ovale (PFO) (4.05%), VSD + ASD + primary PH (2.92%) and VSD + ASD + secondary PH + pneumonia (0.53%). Characteristics of the combinations were examined, and age, with the highest prevalence seen in those aged between 0 and 1 year, number of operations (p < 0.001 in each comorbidity group), length of stay (LOS) (p = 0.001 in the 2 comorbidities group; p = 0.002 in the 4 comorbidities group) and hospitalization cost (p < 0.001 in the 2 comorbidities group; p = 0.011 in the 3 comorbidities group) differed significantly.
Conclusions
VSD + ASD, VSD + ASD + PH, and VSD + ASD + PDA + secondary PH occurred most frequently in each comorbidity group. Age, number of operations, LOS and hospitalization cost were significant among these combinations, which emphasizes the importance of a better understanding, diagnosis and treatment for complex comorbidities of VSD in young populations to improve clinical outcomes and provide guidance for relevant policies on resource utilization.
Indirect Taxes, Inflation and Inequality in Turkey
Authors: Gemicioğlu Selçuk , Akkoç Uğur , Kızılırmak Burça 
Published: December 2022

AbstractOne way inflation affects inequality is through its varying impact on the purchasing power of different households. Indirect taxes, which affect commodity price levels, are another effective factor influencing inequality. Turkey is a highly unequal country with a long history of high inflation. Moreover, indirect taxes have been used frequently as a policy tool in the last decades. This study applies the commonly used method in the literature to analyse distributional consequences of household level inflation rates, and extends it to analyse the role of indirect tax changes in this relationship. The analysis is carried out using both household-level data and artificial panel data created to apply the Shapley and Owen decomposition methods. The findings indicate that while nominal consumption during the 2003–2019 period became more equal, real consumption inequality increased as a result of price changes during that time. Another striking finding is that changes in indirect taxes account for 31–57% of the unequalizing effect of price changes, depending on the method used.
Inter- and intraspecific plant-soil feedbacks of grass species.
Authors: Rallo Paola , Hannula S. Emilia , Hooven Freddy C. ten , Verhoeven Koen J.F. , Kammenga Jan , Putten Wim H. van der 
Published: December 2022

Abstract

Background and aims Plants continuously interact with soil microbiota. These plant-soil feedbacks (PSFs) are considered a driving force in plant community dynamics. However, most PSF information comes from inter-family studies, with limited information on possible causes. We studied the variation of PSFs between and within grass species and identified the soil microbes that are associated with the observed PSFs effects. Methods We grew monocultures of ten varieties of three grass species (Lolium perenne, Poa pratensis, Festuca arundinacea) using a two-phase PSF experiment. We measured plant total biomass to determine PSFs and correlated it with sequenced rhizosphere bacteria and fungi. Results In the soil conditioning phase, grass species developed microbial legacies that affected the performance of other grass species in the feedback phase. We detected overall negative interspecific PSFs. While we show thatL. perenneandP. pratensisincreased their performance respectively in conspecific and heterospecific soils,F. arundinaceawas not strongly affected by the legacies of the previous plant species. Contrary to our expectation, we found no evidence for intraspecific variation in PSFs. Bacterial taxa associated with PSFs included members ofProteobacteria,Firmicutes, VerrucomicrobiaandPlanctomyceteswhereas fungal taxa included members ofAscomycota.Conclusion Our results suggest differences in PSF effects between grass species, but not between varieties within species. Thus, in the studied grass species, there might be limited potential for breeding on plant traits mediated by PSFs. Furthermore, we point out potential microbial candidates that might be driving the observed PSF effects that could be further explored.
High blood sugar may blunt the protective benefits of FXR for the survival of renal medullary collecting duct cells in response to hypertonic stress
Authors: Wei Tuo , Zhou Enchao 
Published: December 2022

AbstractBackgroud: Diabetic nephropathy is the most common renal complication of diabetes and the leading cause of end-stage renal disease. many factors lead to the occurrence of this disease. However, little attention has been paid to the effect of water deficiency on DN. This study focused on the effect of dehydration on renal injury in diabetes mellitus. Methods Diabetic and non-diabetic mice were deprived of water every other day for a total of 16 weeks. The effects of water deficiency on kidney of diabetic and non-diabetic mice were analyzed by physiological indexes, biochemical tests, pathology and the expression changes of proteins. Finally, we verified the important role of farnesoid X receptor transcription factor(FXR) in renal injury caused by dehydration once again through the study of FXR knockout mice. Results Our animal studies confirmed that kidney injury was more obvious in diabetic mice after water deprivation.Diabetic mice had increased urine volume and serum concentrations of creatinine after dehydration, pathological injury of renal medulla was also observed. We further demonstrated that glycoprotein 91/ aquaporin 2 expression increased in renal medulla under water deficiency, especially under high blood serum glucose concentrations. At the same time, in high sugar environment, dehydration caused overexpression of FXR and tonicity-responsive enhancer-binding protein(TonEBP), which led to oxidative stress damage to the renal medulla. However, this oxidative stress damage was weakened after FXR knockout. Conclusions Hypertonic conditions in high glucose environments promote overexpression of FXR. It binds TonEBP in the renal medulla, thus leading to excessive oxidative stress damage and ultimately to renal medulla damage.
Evaluation of soft tissue release in mild-to-moderate medial knee osteoarthritis in the presence of medial synovial plica, using clinical and MRI parameters
Authors: Lee Hsin-Pai , Chou Chun-Hsiung , Tzeng Wen-Sheng , Yeh Hui-Shu , Chen Mei-Ju 
Published: December 2022

Abstract
Objective.
To evaluate the clinical outcomes of an arthroscopic soft tissue release procedure for the treatment of mild to moderate knee osteoarthritis.
Materials and methods.
This study involved 40 subjects who underwent arthroscopic release in knee osteoarthritis including Kellgren–Lawrence grades 2 and 3 between January 2019 and January 2021. The Western Ontario and McMaster Universities (WOMAC) scores at baseline and at 6 months following surgery were recorded. Magnetic resonance imaging (MRI) was performed pre- and postoperatively (6 months). The parameters for patellar instability, including patellar tilt angle, bisect offset, tibial tuberosity–trochlear groove distance and the Insall–Salvati ratio, were measured preoperatively and postoperatively. Quantitative measurements of bone marrow lesions were also conducted.
Results.
The mean WOMAC score for pain and the total score improved statistically 6 months after surgery. The pain and overall scores improved significantly (reductions of 64.6% and 39.3%, respectively) at 6 months. Pain score improved from 7.0 ± 3.0 to 2.5 ± 2.8 (P < 0.05), with the total score improving from17.8 ± 10.3 to 10.8 ± 10.6 (P < 0.05). Bone marrow lessions decreased from 8503 mm3 to 2250 mm3 (P < 0.05). Patellar tilt decreased from 5.11 to 4.24 (P < 0.05). The Insall–Salvati ratio decreased significantly from 1.13 ± 0.13 to 1.08 ± 0.12 (P < 0.05).
Conclusion.
Overall, the results suggest that soft tissue release has clinical symptoms and structure-modifying effects in patients with knee osteoarthritis.