bluuebunny/crossref_metadata_2025_split huggingface dataset:
Routine laboratory biomarkers used to predict Gram-positive or Gram-negative bacteria involved in bloodstream infections
Authors: Dambroso-Altafini Daniela , Menegucci Thatiany C. , Costa Bruno B. , Moreira Rafael R. B. , Nishiyama Sheila A. B. , Mazucheli Josmar , Tognim Maria C. B. 
Published: September 2022

AbstractThis study evaluated routine laboratory biomarkers (RLB) to predict the infectious bacterial group, Gram-positive (GP) or Gram-negative (GN) associated with bloodstream infection (BSI) before the result of blood culture (BC). A total of 13,574 BC of 6787 patients (217 BSI-GP and 238 BSI-GN) and 68 different RLB from these were analyzed. The logistic regression model was built considering BSI-GP or BSI-GN as response variable and RLB as covariates. After four filters applied total of 320 patients and 16 RLB remained in the Complete-Model-CM, and 4 RLB in the Reduced-Model-RM (RLB p > 0.05 excluded). In the RM, only platelets, creatinine, mean corpuscular hemoglobin and erythrocytes were used. The reproductivity of both models were applied to a test bank of 2019. The new model presented values to predict BSI-GN of the area under the curve (AUC) of 0.72 and 0.69 for CM and RM, respectively; with sensitivity of 0.62 and 0.61 (CM and RM) and specificity of 0.67 for both. These data confirm the discriminatory capacity of the new models for BSI-GN (p = 0.64). AUC of 0.69 using only 4 RLB, associated with the patient's clinical data could be useful for better targeted antimicrobial therapy in BSI.
Discrete-time survival analysis in the critically ill: a deep learning approach using heterogeneous data
Authors: Thorsen-Meyer Hans-Christian , Placido Davide , Kaas-Hansen Benjamin Skov , Nielsen Anna P. , Lange Theis , Nielsen Annelaura B. , Toft Palle , Schierbeck Jens , Strøm Thomas , Chmura Piotr J. , Heimann Marc , Belling Kirstine , Perner Anders , Brunak Søren 
Published: September 2022

AbstractPrediction of survival for patients in intensive care units (ICUs) has been subject to intense research. However, no models exist that embrace the multiverse of data in ICUs. It is an open question whether deep learning methods using automated data integration with minimal pre-processing of mixed data domains such as free text, medical history and high-frequency data can provide discrete-time survival estimates for individual ICU patients. We trained a deep learning model on data from patients admitted to ten ICUs in the Capital Region of Denmark and the Region of Southern Denmark between 2011 and 2018. Inspired by natural language processing we mapped the electronic patient record data to an embedded representation and fed the data to a recurrent neural network with a multi-label output layer representing the chance of survival at different follow-up times. We evaluated the performance using the time-dependent concordance index. In addition, we quantified and visualized the drivers of survival predictions using the SHAP methodology. We included 37,355 admissions of 29,417 patients in our study. Our deep learning models outperformed traditional Cox proportional-hazard models with concordance index in the ranges 0.72–0.73, 0.71–0.72, 0.71, and 0.69–0.70, for models applied at baseline 0, 24, 48, and 72 h, respectively. Deep learning models based on a combination of entity embeddings and survival modelling is a feasible approach to obtain individualized survival estimates in data-rich settings such as the ICU. The interpretable nature of the models enables us to understand the impact of the different data domains.
Disengaging spinal afferent nerve communication with the brain in live mice
Authors: Kyloh Melinda A. , Hibberd Timothy J. , Castro Joel , Harrington Andrea M. , Travis Lee , Dodds Kelsi N. , Wiklendt Lukasz , Brierley Stuart M. , Zagorodnyuk Vladimir P. , Spencer Nick J. 
Published: September 2022

AbstractOur understanding of how abdominal organs (like the gut) communicate with the brain, via sensory nerves, has been limited by a lack of techniques to selectively activate or inhibit populations of spinal primary afferent neurons within dorsal root ganglia (DRG), of live animals. We report a survival surgery technique in mice, where select DRG are surgically removed (unilaterally or bilaterally), without interfering with other sensory or motor nerves. Using this approach, pain responses evoked by rectal distension were abolished by bilateral lumbosacral L5-S1 DRG removal, but not thoracolumbar T13-L1 DRG removal. However, animals lacking T13-L1 or L5-S1 DRG both showed reduced pain sensitivity to distal colonic distension. Removal of DRG led to selective loss of peripheral CGRP-expressing spinal afferent axons innervating visceral organs, arising from discrete spinal segments. This method thus allows spinal segment-specific determination of sensory pathway functions in conscious, free-to-move animals, without genetic modification.
Impairment of IgG Fc functions promotes tumor progression and suppresses NK cell antitumor actions
Authors: Fan Xuejun , Yuan Zihao , Zhao Yueshui , Xiong Wei , Hsiao Hao-Ching , Pare Rahmawati , Ding Jianmin , Almosa Ahmad , Sun Kai , Zhang Songlin , Jordan Robert E. , Lee Cheok Song , An Zhiqiang , Zhang Ningyan 
Published: September 2022

AbstractNatural killer (NK) cells mediate antibody dependent cytotoxic killing of cancer cells via cross-linking FcγR on NK cells with IgG-Fc. Studies have shown that the single-hinge cleaved IgGs (scIgGs) have dysfunctional Fc and failed engagement with FcγRs on immune cells. However, little is known about how scIgGs impact on antitumor immunity in the tumor microenvironment. In this study, we revealed a significant association of tumor scIgGs with tumor progression and poor outcomes of breast cancer patients (n = 547). Using multiple mouse tumor models, we demonstrated that tumor scIgGs reduced NK cell cytotoxic activities and resulted in aggressive tumor progression. We further showed that an anti-hinge specific monoclonal antibody (AHA) rescued the dysfunctional Fc in scIgGs by providing a functional Fc and restored NK cell cytotoxic activity. These findings point to a novel immunotherapeutic strategy to enhance Fc engagement with FcγRs for activation of anticancer immunity.
Clustering of Disfluencies in Informal Conversations of People With Cluttering
Authors: Pap Johanna 
Published: September 2022

Purpose:
The aim of this study was to explore the characteristics of disfluency clusters in cluttering in conversation depending on the relationship of communication partners.

Method:
Ten-minute speech samples of conversations between people with cluttering (PWC) and people who do not clutter (PWNC) were analyzed for disfluencies. For each sample taken, participants were paired with either friends or unknown partners. PWC were also paired with PWNC and with each other. The influence of the different conversational partners on the type and frequency of disfluency was examined.

Results:
In all conversation samples, PWC exhibited 2.4 times more complex disfluencies than PWNC. In addition, the frequency of complex disfluencies was influenced by the independent variables of PWC/PWNC and relationship of conversational partner. More complex disfluencies were produced by PWC in the conversations with a PWNC friend and with an unknown PWC as compared to conversations with an unknown PWNC and a PWC friend.

Conclusions:
Results confirm clinical observations that cluttering disfluencies may increase with more familiar conversational partners. However, atypical speech may also increase severity of symptoms. Findings also provide objective information about cluttering in relatively naturalistic situations.
Retracted: Research on tridimensional monitoring and defence technology of substation
Authors: Qiu Kaiyi , Liu Xin , Liu Jie , Ma Hongbo , Li Jingya , Zhang Zhengchao , Chen Guangliang , Cai Li 
Published: September 2022

AbstractRetraction: [Kaiyi Qiu, Xin Liu, Jie Liu, Hongbo Ma, Jingya Li, Zhengchao Zhang, Guangliang Chen, Li Cai, Research on tridimensional monitoring and defence technology of substation, IET Circuits, Devices & Systems 2022 (https://doi.org/10.1049/cds2.12129)].The above article from IET Circuits, Devices & Systems, published online on 14 September 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor‐in‐Chief, Harry E. Ruda, the Institution of Engineering and Technology (the IET) and John Wiley and Sons Ltd. This article was published as part of a Guest Edited special issue. Following an investigation, the IET and the journal have determined that the article was not reviewed in line with the journal’s peer review standards and there is evidence that the peer review process of the special issue underwent systematic manipulation. Accordingly, we cannot vouch for the integrity or reliability of the content. As such we have taken the decision to retract the article. The authors have been informed of the decision to retract.
A deep learning and ensemble learning based architecture for metro passenger flow forecast
Authors: Wang Xin , Zhu Changfeng , Jiang Jiahao 
Published: September 2022

AbstractAccurate short‐term forecast of metro outbound passenger flow is of great significance for real‐time traffic control and guidance. A good forecast method should have high accuracy, timeliness and practicality. Based on deep learning and ensemble learning technology, this study proposes an end‐to‐end forecast hybrid architecture for metro outbound passenger flow that integrates multiple passenger flow features. The architecture innovatively integrates bagging ensemble learning strategy and transfer learning with deep learning, and includes multiple extensible passenger flow feature processing components. In addition, this study presents a new coding method to incorporate the operating characteristics of the metro into the forecasting architecture. Use the automatic fare collection (AFC) data of Chengdu Metro Tianfu Square Station for training and verify the forecast architecture on workdays, weekends and holidays. The results reveal that compared with other widely used passenger flow forecast models, the architecture proposed in this study has achieved the highest forecast accuracy in the above‐mentioned different time types. Furthermore, the fusion of transfer learning improves the accuracy of forecast model while significantly speeding up the convergence of training, increasing its timeliness and practicability.
The role of topogram views on dose indices and image quality in thorax and abdomen-pelvis CT scan
Authors: Hadipour D. , Monfared A.S. , Ebrahiminia A. , Gorji K.E. , Ghaemian N. , Niksirat F. 
Published: September 2022

This study was designed to investigate the effect of the different topograms (AP and dual AP/Lateral) on patient dose indices and image quality in thorax and abdomen-pelvis CT. Size-specific dose estimation (SSDE), volumetric CT dose index (CTDIvol), milliampere seconds (mAs), effective dose, as well as signal to noise ratio (SNR) and contrast to noise ratio (CNR) of 60 thorax and 60 abdomen-pelvis CT scans were analyzed. In thorax CT, SSDE, mAs, CTDIvol and effective dose were significantly reduced by using dual topograms (p < 0.05) but not significantly reduced in abdominal-pelvic scans (p > 0.05). There was no significant difference between CNR parameter in the two groups for thorax CT (p > 0.05) and SNR parameter in abdomen-pelvic CT (p < 0.05) and all images were diagnostically acceptable. The use of two topograms in thorax CT is an efficient approach to reduce dose indices without decreasing the image quality.
Screening for head and neck tumors in patients with esophageal squamous cell carcinoma and vice versa: a nationwide survey among medical specialists
Authors: van Tilburg Laurelle , van den Ban Sophie A. , van de Ven Steffi E.M. , Sewnaik Aniel , Bruno Marco J. , Spaander Manon C.W. , Baatenburg de Jong Robert J. , Koch Arjun D. 
Published: September 2022

Abstract
Background and study aims Retrospectively, minimally 5% of patients with esophageal squamous cell carcinoma (ESCC) and 11 % with head and neck squamous cell carcinoma (HNSCC) in Western countries developed a second primary tumor (SPT). SPT screening in ESCC and HNSCC patients is not implemented routinely in daily practice in many Western countries. This study aimed to assess medical specialist knowledge and opinions regarding screening for head and neck SPTs (HNSPTs) in ESCC patients and vice versa in the Netherlands.
Methods A nationwide survey among gastroenterologists and head and neck (HN) surgeons was conducted between December 2020 and March 2021. The survey consisted of 27 questions and focused on knowledge of medical specialists of the prevalence and opinions toward implementing screening for HNSPTs in ESCC patients and vice versa.
Results One hundred twenty-eight gastroenterologists (20.5 %) and 31 HN surgeons (50.0 %) completed the survey. The expected median prevalence of HNSPTs in ESCC was 7.0 % (interquartile range [IQR]: 5.0–15.0) among gastroenterologists and 5.0 % (IQR:3.0–8.0) among HN surgeons. For ESPTs in HNSCC, the expected median prevalence was 9.5 % (IQR: 5.0–12.0) among gastroenterologists and 4.0 % (IQR: 2.0–5.0) among HN surgeons. Screening for HNSPTs and ESPTs was considered promising by 35.2 % and 39.6 %, respectively, which increased to 54.7 % of the specialists after providing incidence data on SPTs. Of the HN surgeons, 41.3 % felt they were as capable as gastroenterologists of performing esophageal screening.
Conclusions This Dutch nationwide survey revealed a lack of knowledge and different perspectives among specialists about screening to detect SPTs in ESCC and HNSCC patients. Adequate education seems essential to increase awareness among specialists and improve SPT detection, independent of the need for implementation of screening for SPTs in ESCC and HNSCC patients.
The Role of Autologous Fat Grafting in Rhinoplasty
Authors: Saadoun Rakan , Solari Mario G. , Rubin J. Peter 
Published: September 2022

AbstractRhinoplasty is one of the most popular aesthetic surgeries worldwide and often includes grafting techniques to achieve optimal results. One of these grafting techniques is autologous fat transfer, which has been used to increase volume, camouflage irregularities, and/or improve the quality of the nasal skin–soft tissue envelope. Moreover, minimally invasive approaches for altering the nasal appearance have recently increased and become known as “liquid” or “nonsurgical rhinoplasty.” These nonsurgical approaches include altering the nasal appearance with filler injection to induce volumetric changes in lieu of extensive surgery. The use of fat grafting as a filler is favorable to achieve well-balanced aesthetic results without compromising the nasal skin–soft tissue envelope. This capability is partly because of the regenerative potential of fat grafts, serving to improve the quality of surrounding soft tissues. In contrast, commercial injectable fillers are inert. This article highlights the role of fat grafting in surgical and nonsurgical rhinoplasty to provide surgeons with an overview of the potential of these vastly abundant, biocompatible, and cost-effective grafts.
Efficacy, Retention Rate, and Influencing Factors of Ketogenic Diet Therapy in Children with Refractory Epilepsy: A Retrospective Study
Authors: Shen Jue , Jiang Tiejia , Gao Feng , Jiang Kewen 
Published: September 2022

Abstract
Background This study aimed to evaluate the efficacy and retention rate of a ketogenic diet (KD) and assess factors that influence the efficacy of KD therapy in children with refractory epilepsy (RE).
Methods We retrospectively studied the efficacy and retention rate of 56 RE children who accepted KD therapy from January 2013 to December 2019. Patients who had a ≥50% reduction in seizure frequency were defined as responders. The retention rate was calculated as the proportion of children who continued KD/the total number of children who were followed up at the time of enrollment. We also analyzed the effects of different factors (such as gender, KD initial age, KD duration, the type of epilepsy syndrome, and others) on the efficacy of the KD.
Results (1) The efficacy rates for the KD at 3, 6, 12, and 18 months were 51.8, 53.6, 39.2, and 23.2%, respectively. (2) The retention rates for the KD at 3, 6, 12 and 18 months were 100, 69.6, 41.1, and 23.2%, respectively. (3) There was no correlation between efficacy and gender, epilepsy onset age, the type of epilepsy syndrome, electroencephalogram improvement, or the number of antiseizure medications, while cranial magnetic resonance imaging (MRI) abnormalities, KD duration, and KD initial age affected its efficacy at 3 months.
Conclusion (1) KD therapy for refractory childhood epilepsy was effective and produced a high retention rate. (2) MRI abnormalities and the initial age and duration of KD influenced its short-term efficacy in RE children.
Evaluating YouTube as a Source of Patient Information for Blefaroplasty
Authors: Savran Fatih , Elibol Emine S. 
Published: September 2022

AbstractThis study aims to evaluate the content and quality of popular videos about blepharoplasty treatment in YouTube. Four keywords “blepharoplasty,” “upper blepharoplasty,” “lower blepharoplasty,” and “blepharoplasty information” were searched in YouTube. After the videos were sorted by the number of views, the last 50 videos were based on general characteristics, primary purpose, information content, relevance, audiovisual quality, as well as viewer interaction index DISCERN score (minimum–maximum: 16–75), Journal of the American Medical Association (JAMA) score (minimum–maximum: 0–4), and Global Quality score (minimum–maximum: 0–5), and view rate formulas were calculated for each video. A total of the best 49 videos were evaluated in our study. The total number of views of these videos was 10,938,976. The total duration of these videos was 409minutes. The average duration of the videos was 8.35±8.38 (standard deviation [SD]). There was no significant (p>0.05) correlation between the measurement of DISCERN scores of the two observers. A significant (p<0.05) difference was observed between the JAMA score measurements of the two observers. There was no significant difference (p>0.05) between the GQS score measurements of the two observers. Currently, YouTube is not a viable resource for patients to learn about blepharoplasty. Physicians should be aware of the limitations and provide up-to-date and peer-reviewed content on the web site, and patients should also be warned about obtaining information.
Patient-Reported Outcome Analysis after Resident Performed Upper Blepharoplasty: A Suitable Procedure for Young Surgeons
Authors: Mahrhofer Maximilian , Schwaiger Karl , Weitgasser Laurenz , Schoeller Thomas , Hitzl Wolfgang , Wechselberger Gottfried 
Published: September 2022

AbstractUpper blepharoplasty is one of the most frequently performed aesthetic surgeries worldwide. While it is considered a low risk procedure, patients have high expectations regarding the outcome of elective surgery of the face and the majority of residents usually have little exposure to cosmetic surgeries in the early years of their training. All eligible patients who had undergone bilateral upper blepharoplasty at the senior author's institution between January 2016 and August 2019 were invited to participate in an online questionnaire. Our study used a 27-item questionnaire to evaluate postoperative patient satisfaction and compared the patient reported outcome between operations conducted by surgeons with more than 3 years of experience and less than 3 years. In total, 102 patients returned the completed questionnaire and were included in our study after further screening. There was no significant difference in patient reported satisfaction concerning the aesthetic outcome (8.75 vs. 8.29, p=0.49), and complications (6.2 vs. 18.6%, p=0.63), related to the experience of the surgeons. Overall patient satisfaction was very high, while the rate of complications was low. Patient reported aesthetic outcomes after blepharoplasty demonstrated no significant difference comparing the experience of the surgeons.
Assessment of Dentofacial Characteristics and Pharyngeal Airway in Children with Class II Malocclusion and Mouth Breathing
Authors: Shetty Swathi , Shetty Vabitha , Bhandary Meghna 
Published: September 2022

Abstract
Background In growing patients with skeletal discrepancies, early diagnosis, evidence-based explanation of etiology, and assessment of functional factors can be vital for the restoration of normal craniofacial growth and the stability of treatment needs.
Aims The aim of the study was to assess dentofacial characteristics as well as upper and lower pharyngeal airway in children with skeletal class II malocclusion with mouth breathing, and to investigate possible significant relationships and correlations among the studied cephalometric variables and the airway morphology in these children.
Materials and Methods Sixty untreated children, aged 9 to 13 years, were divided into three groups according to clinical findings and cephalometric analysis of dentofacial characteristics as well as the presence of mouth breathing habit: Group I (20 children with normal jaw relation/class I), Group II (20 children with skeletal class II), and Group III (20 children with skeletal class II with confirmed mouth breathing habit). Cephalometric variables and upper/lower airway widths were recorded. Intergroup comparison of all measurements was performed by post hoc Tukey test, and Pearson's correlation was used to determine the correlation among the variables.
Results Significant changes existed in more than half of the dentofacial measurements among the three groups. Significantly greater skeletal anteroposterior jaw discrepancy and mandibular retrognathism were found in both groups II and III as determined by specific anteroposterior determinants. Children in group III showed significantly increased angle between Sella-Nasion and mandibular plane (SN-MP) angle, y-axis, and a vertical growth pattern. Significant increases in dental measurements, namely upper incisor to Nasion- point A (NA), lower incisor to Nasion - point B (NB), and overjet, were found in group II and group III, while overbite showed a significant decrease. Upper pharyngeal airway width was found to be significantly decreased in group III followed by a smaller though significant decrease in group II. No significant differences were found in lower pharyngeal airway width between the groups. There were statistically significant dentofacial characteristics that showed fair to good correlation with the upper airway width.
Conclusion Children with skeletal class II malocclusion with and without mouth breathing showed significant differences in dentofacial measurements and a significantly narrower upper pharyngeal airway as compared with children with normal jaw/class I relation.