bluuebunny/crossref_metadata_2025_split huggingface dataset:
A quantitative and comparative evaluation of stereotactic spine radiosurgery local control: proposing a consistent measurement methodology
Authors: Harel Ran , Kaisman-Elbaz Tehila , Emch Todd , Elson Paul , Chao Samuel T , Suh John H , Angelov Lilyana 
Published: November 2022

OBJECTIVE
Stereotactic body radiotherapy (SBRT) is a precise and conformal treatment modality used in the management of metastatic spine tumors. Multiple studies have demonstrated its safety and efficacy for pain and tumor control. However, no uniform quantitative imaging methodology exists to evaluate response to treatment in these patients. This study presents radiographic local control rates post-SBRT, systematically compares measurements acquired according to WHO and Response Evaluation Criteria in Solid Tumors (RECIST) criteria, and explores the relationship to patient outcome.

METHODS
The authors performed a retrospective review of prospectively obtained data from a cohort of 59 consecutive patients (81 metastatic isocenters) treated with SBRT and followed with serial MRI scans. Measurements were performed by a neuroradiologist blinded to the patients’ clinical course. Local control status was determined according to both WHO and RECIST measurements, and agreement between the measuring methodologies was calculated and reported.

RESULTS
Eighty-one isocenters (111 vertebral bodies) were treated with SBRT. The mean treatment dose was 13.96 Gy and the median follow-up duration was 10.8 months, during which 408 MRI scans were evaluated with both WHO and RECIST criteria for each scan point. Imaging demonstrated a mean unidimensional size decrease of 0.2 cm (p = 0.14) and a mean area size decrease of 0.99 cm2 (p = 0.03). Although 88% of the case classifications were concordant and the agreement was significant, WHO criteria were found to be more sensitive to tumor size change. The local control rates according to WHO and RECIST were 95% and 98%, respectively.

CONCLUSIONS
Although WHO volumetric measurements are admittedly superior for tumor size measurement, RECIST is simpler, reproducible, and for the first time is shown here to be comparable to WHO criteria. Thus, the application of RECIST methodology appears to be a suitable standard for evaluating post-SBRT treatment response. Moreover, using comprehensive and consistent measuring approaches, this study substantiates the efficacy of SBRT in the treatment of spine metastases.
Neoadjuvant stereotactic radiosurgery for brain metastases: a new paradigm
Authors: Li Yuping Derek , Coxon Andrew T. , Huang Jiayi , Abraham Christopher D. , Dowling Joshua L. , Leuthardt Eric C. , Dunn Gavin P. , Kim Albert H. , Dacey Ralph G. , Zipfel Gregory J. , Evans John , Filiput Eric A. , Chicoine Michael R. 
Published: November 2022

OBJECTIVE
For patients with surgically accessible solitary metastases or oligometastatic disease, treatment often involves resection followed by postoperative stereotactic radiosurgery (SRS). This strategy has several potential drawbacks, including irregular target delineation for SRS and potential tumor "seeding" away from the resection cavity during surgery. A neoadjuvant (preoperative) approach to radiation therapy avoids these limitations and offers improved patient convenience. This study assessed the efficacy of neoadjuvant SRS as a new treatment paradigm for patients with brain metastases.

METHODS
A retrospective review was performed at a single institution to identify patients who had undergone neoadjuvant SRS (specifically, Gamma Knife radiosurgery) followed by resection of a brain metastasis. Kaplan-Meier survival and log-rank analyses were used to evaluate risks of progression and death. Assessments were made of local recurrence and leptomeningeal spread. Additionally, an analysis of the contemporary literature of postoperative and neoadjuvant SRS for metastatic disease was performed.

RESULTS
Twenty-four patients who had undergone neoadjuvant SRS followed by resection of a brain metastasis were identified in the single-institution cohort. The median age was 64 years (range 32–84 years), and the median follow-up time was 16.5 months (range 1 month to 5.7 years). The median radiation dose was 17 Gy prescribed to the 50% isodose. Rates of local disease control were 100% at 6 months, 87.6% at 12 months, and 73.5% at 24 months. In 4 patients who had local treatment failure, salvage therapy included repeat resection, laser interstitial thermal therapy, or repeat SRS. One hundred thirty patients (including the current cohort) were identified in the literature who had been treated with neoadjuvant SRS prior to resection. Overall rates of local control at 1 year after neoadjuvant SRS treatment ranged from 49% to 91%, and rates of leptomeningeal dissemination from 0% to 16%. In comparison, rates of local control 1 year after postoperative SRS ranged from 27% to 91%, with 7% to 28% developing leptomeningeal disease.

CONCLUSIONS
Neoadjuvant SRS for the treatment of brain metastases is a novel approach that mitigates the shortcomings of postoperative SRS. While additional prospective studies are needed, the current study of 130 patients including the summary of 106 previously published cases supports the safety and potential efficacy of preoperative SRS with potential for improved outcomes compared with postoperative SRS.
CyberKnife radiosurgery for trigeminal neuralgia: a retrospective review of 168 cases
Authors: Guillemette Albert , Heymann Sami , Roberge David , Ménard Cynthia , Fournier-Gosselin Marie-Pierre 
Published: November 2022

OBJECTIVE
Gamma Knife radiosurgery is recognized as an efficient intervention for the treatment of refractory trigeminal neuralgia (TN). The CyberKnife, a more recent frameless and nonisocentric radiosurgery alternative, has not been studied as extensively for this condition. This study aims to evaluate the clinical outcomes of a first CyberKnife radiosurgery (CKRS) treatment in patients with medically refractory TN.

METHODS
A retrospective cohort study of 166 patients (168 procedures) with refractory TN treated from 2009 to 2021 at the Centre Hospitalier de l’Université de Montréal was conducted. The treatment was performed using a CyberKnife (model G4, VSI, or M6). The treatment median maximum dose was 80 (range 70.0–88.9) Gy.

RESULTS
Adequate pain relief, evaluated using Barrow Neurological Institute pain scale scores (I–IIIb), was achieved in 146 cases (86.9%). The median latency period before adequate pain relief was 35 (range 0–202) days. The median duration of pain relief for cases with a recurrence of pain was 8.3 (range 0.6–85.0) months. The actuarial rates of maintaining adequate pain relief at 12, 36, and 60 months from the treatment date were 77.0%, 62.5%, and 50.2%, respectively. There was new onset or aggravation of facial numbness in 44 cases (26.2%). This facial numbness was predictive of better maintenance of pain relief (p < 0.001). The maintenance of adequate pain relief was sustained longer in idiopathic cases compared with cases associated with multiple sclerosis (MS; p < 0.001).

CONCLUSIONS
In the authors’ experience, CKRS for refractory TN is efficient and safe. The onset or aggravation of facial hypoesthesia after treatment was predictive of a more sustained pain relief, and idiopathic cases had more sustained pain relief in comparison with MS-related cases.
Risk factors for peritumoral edema after radiosurgery for intracranial benign meningiomas: a long-term follow-up in a single institution
Authors: Huang Sheng-Han , Chuang Chi-Cheng , Wang Chun-Chieh , Wei Kuo-Chen , Chen Hsien-Chih , Hsu Peng-Wei 
Published: November 2022

OBJECTIVE
Peritumoral edema (PTE) is recognized as a complication following stereotactic radiosurgery (SRS). The aim of this paper was to evaluate the risk of post-SRS PTE for intracranial benign meningiomas and determine the predictive factors.

METHODS
Between 2006 and 2021, 227 patients with 237 WHO grade I meningiomas were treated with Novalis linear accelerator SRS. All patients were treated with a single-fraction dose of 11–20 Gy (median 14 Gy). The median tumor volume was 3.32 cm3 (range 0.24–51.7 cm3).

RESULTS
The median follow-up was 52 months (range 12–178 months). The actuarial local tumor control rates at 2, 5, and 10 years after SRS were 99.0%, 96.7%, and 86.3%, respectively. Twenty-seven (11.9%) patients developed new or worsened post-SRS PTE, with a median onset time of 5.2 months (range 1.2–50 months). Only 2 patients developed post-SRS PTE after 24 months. The authors evaluated factors related to new-onset or worsened PTE after SRS. In univariate analysis, initial tumor volume > 10 cm3 (p = 0.03), total marginal dose > 14 Gy (p < 0.001), preexisting edema (p < 0.0001), tumor location (p < 0.001), parasagittal location (p < 0.0001), superior sagittal sinus (SSS) involvement (p < 0.0001), and SSS invasion (p < 0.015) were found to be significant risk factors. In multivariate analysis, total marginal dose > 14 Gy (HR 3.38, 95% CI 1.37–8.33, p = 0.008), preexisting SRS edema (HR 12.86, 95% CI 1.09–4.15, p < 0.0001), tumor location (HR 2.13, 95% CI 1.04–3.72, p = 0.027), parasagittal location (HR 8.84, 95% CI 1.48–52.76, p = 0.017), and SSS invasion (HR 0.34, 95% CI 0.13–0.89, p = 0.027) were significant risk factors. Twelve (5.3%) patients were symptomatic. Ten of 27 patients had complete resolution of neurological symptoms and edema improvement with steroid treatment. Steroid treatment failed in 2 patients, who subsequently required resection for PTE.

CONCLUSIONS
Radiosurgery is a safe and effective method of treating benign intracranial meningiomas according to long-term follow-up. We also identified total marginal dose > 14 Gy, preexisting PTE, parasagittal location, and SSS invasion as predictors of post-SRS PTE. Risk factors for post-SRS PTE should be considered in meningioma treatment.
Stereotactic radiosurgery for trigeminal neuralgia secondary to tumor: a single-institution retrospective series
Authors: Hall Jennifer C. , Ung Timothy H. , McCleary Tamra-Lee , Chuang Cynthia , Gibbs Iris C. , Soltys Scott G. , Hayden Gephart Melanie , Li Gordon , Pollom Erqi L. , Chang Steven D. , Meola Antonio 
Published: November 2022

OBJECTIVE
Trigeminal neuralgia (TN) secondary to tumor represents a rare and diverse entity, and treatment for secondary TN remains controversial. This report reviews a single institution’s experience in treating secondary TN with stereotactic radiosurgery (SRS) and focuses on the durability of pain relief with respect to various treatment targets, i.e., the trigeminal nerve, offending tumor, or both.

METHODS
Between the years 2009 and 2021, 21 patients with TN secondary to benign (n = 13) or malignant (n = 8) tumors underwent SRS. Barrow Neurological Institute (BNI) pain intensity scale scores were collected from patient electronic medical records at baseline, initial follow-up, and 1 and 3 years post-SRS. The interval change in BNI scale score (ΔBNI) at the various follow-up time points was also calculated to assess the durability of pain relief following SRS.

RESULTS
The median follow-up period was 24 (range 0.5–155) months. Five patients (24%) received treatment to the trigeminal nerve only, 10 (48%) received treatment to the tumor only, and 6 (29%) had treatment to both the nerve and tumor. The overall radiation dosage ranged from 14 to 60 Gy delivered in 1–5 fractions, with a median overall dose of 26 Gy. The median dose to the tumor was 22.5 (range 14–35) Gy, delivered in 1–5 fractions. Of the treatments targeting the tumor, 25% were delivered in a single fraction with doses ranging from 14 to 20 Gy, 60% were delivered in 3 fractions with doses ranging from 18 to 27 Gy, and 15% were delivered in 5 fractions with doses ranging from 25 to 35 Gy. The most common dose regimen for tumor treatment was 24 Gy in 3 fractions. The median biologically effective dose (with an assumed alpha/beta ratio of 10 [BED10]) for tumor treatments was 43.1 (range 13.3–60.0) Gy. There was a significant difference in the proportion of patients with recurrent pain (ΔBNI score ≥ 0) at the time of last follow-up across the differing SRS treatment targets: trigeminal nerve only, tumor only, or both (p = 0.04). At the time of last follow-up, the median ΔBNI score after SRS to the nerve only was −1, 0 after SRS to tumor only, and −2 after SRS to both targets.

CONCLUSIONS
SRS offers clinical symptomatic benefit to patients with TN secondary to tumor. For optimal pain relief and response durability, treatment targeting both the tumor and the trigeminal nerve appears to be most advantageous.
MODEL BANGKITAN DAN TARIKAN PADA PUSAT KEGIATAN PERGURUAN TINGGI DI KABUPATAEN INDRAMAYU
Authors: Sarwanta Sarwanta , Abdulgani Hamdani , Arief Oki 
Published: November 2022

Setiap pusat kegiatan akan menimbulkan dampak lalu lintas pada jalan akses yang menghubungkan pusat kegiatan tersebut dengan lingkungan sekitarnya. Lalu lintas yang ditimbulkan berupa lalu lintas menuju pusat kegiatan (tarikan) maupun lalu lintas yang meninggalkannya (Bangkitan). Keberadaan kampus di kota Indramayu sebagai salah satu pusat kegiatan pendidikan perlu diketahui dampak lalu lintas yang ditimbulkannya. Tujuan dari penelitian ini untuk menyusun model bangkitan dan tarikan lalu lintas untuk mengetahui besarnya dampak lalu lintas yang timbul dengan adanya keberadaan perguruan tinggi yang ada di Kota Indramayu. Dengan diketahuinya dampak lalu lintas yang ditimbulkan, maka dapat membantu pihak yang berwenang membuat kebijakan untuk langkah antisipasi. Hasil analisis faktor yang mempengaruhi tarikan dan bangkitan perjalanan kendaraan di beberapa perguruan tinggi yang ada di Kabupaten Indramayu yaitu jumlah mahasiswa. Model tarikan perjalanan kendaraan menuju perguruan tinggi yang ada di Kabupaten Indramayu adalah Y1 = 22,432 + 0,040X1, dengan Y1 =Tarikan perjalanan kendaraan (smp/jam) dan X1 adalah Jumlah mahasiswa (orang). Model bangkitan lalu lintasnya adalah Y2 = 10,500 + 0,040 X1, Dimana Y2 adalah bangkitan perjalanan kendaraan (smp/jam) dan X1 adalah Jumlah mahasiswa (orang).
Kesalahan siswa dalam menyelesaikan soal cerita tentang bangun ruang sisi lengkung menggunakan prosedur newman
Authors: Lestari Liya , Afriansyah Ekasatya Aldila 
Published: November 2022

The fact that many students still struggle with mathematical concepts like the material of curved side space is what spurred this research. This study set out to investigate the errors that students make when applying Newman's technique to narrative problems with curved side spaces. Methodology for descriptive qualitative research is used. Three students who reside in the village of Radug were selected as samples using the purposive sampling technique from a population of all students who had studied the Constructing Curved Side Space content. Tests, field notes, observations, and interviews are just a few of the data collection procedures used. The steps of data reduction, presentation, and conclusion are the data analysis technique used. According to the study's findings, there were 16% reading errors, 50% problem understanding errors, 33% transformation errors, 55% process skills faults, and 59% writing errors in the final answer. Problem-solving is still a joint task that must be solved, so there is a need for other research that can help analyze mathematical errors. Penelitian ini dilatarbelakangi oleh masih banyaknya siswa yang mengalami kesulitan dalam memahami ide-ide dasar matematika, termasuk ruang sisi lengkung. Penelitian ini melihat kesalahan yang dibuat siswa saat memanfaatkan proses Newman untuk menyelesaikan cerita ruang sisi lengkung. Metodologi penelitian ini adalah deskriptif kualitatif. Purposive sampling digunakan untuk mengambil tiga siswa dari desa Radug sebagai sampel dari populasi semua siswa yang sebelumnya telah mempelajari konten untuk Membangun Sisi Lengkung Ruang. Beberapa metode yang digunakan untuk mengumpulkan data meliputi tes, catatan, observasi, dan wawancara. Teknik analisis data meliputi tahapan reduksi data, penyajian, dan penarikan data. Menurut temuan penelitian, ada 16% kesalahan membaca, 50% kesalahan pemahaman masalah, 33% kesalahan transformasi, 55% kesalahan keterampilan proses, dan 59% kesalahan menulis dalam jawaban akhir. Pemecahan masalah masih menjadi tugas bersama yang harus diselesaikan, maka perlu adanya penelitian lain yang bisa membantu menganalisa kesalahan matematis.
Local passive heating administered during recovery impairs subsequent isokinetic knee extension exercise performance
Authors: Chang Yongling , Liu Xin , Hurr Chansol 
Published: November 2022

BACKGROUND: Passive heating has attracted attention as a potentially promising recovery modality in sports. However, investigations of passive heating have yielded only inconsistent results for exercise performance. OBJECTIVE: To investigate the acute effects of local passive heating administered between repeated bouts of isokinetic exercise. METHODS: The experiment was a randomized crossover study. There was a total of three visits including a familiarization visit. During the remaining two visits, eleven healthy men performed three bouts of nine sets of isokinetic knee extensions using their dominant single-leg (30 repetitions/set, 180[Formula: see text]/sec). A 15 min recovery, during which a local passive heating pad at control (CON) or heating (HT) was applied to the rectus femoris, was afforded after the 3rd and 6th sets (Recovery 1 and 2). Isokinetic exercise performance, as assessed by peak torque, total work, and average power was analyzed using two-way repeated-measures ANOVA. RESULTS: Following Recovery 1 and 2, isokinetic exercise performance, as assessed by peak torque, total work, and average power was reduced in Set 4 ([Formula: see text] 0.001, [Formula: see text] 0.001, [Formula: see text] 0.080) and Set 7 ([Formula: see text] 0.001, [Formula: see text] 0.001, [Formula: see text] 0.009) in the HT group relative to the CON group. Electromyography analysis revealed that signal amplitude was lower in the HT group in Set 4 ([Formula: see text] 0.001) subsequent to Recovery 1, and that firing frequency was higher in Set 7 ([Formula: see text] 0.002) in the HT group after Recovery 2. Furthermore, EMG time-frequency maps from one representative participant showed that following Recovery 1 and 2 peak energy decreased during the first five repetitions in Set 4 and 7. CONCLUSIONS: Local passive heating administered during recovery decreased subsequent performance of isokinetic knee extensors, muscle activation ability and increased firing frequency maintaining force output. Therefore, local passive heating is not an appropriate acute recovery strategy for isokinetic exercises.
Effects of the intensity of interval training on aerobic fitness, body composition and resting metabolic rate of women with overweight or obesity: A randomized trial
Authors: Andreato Leonardo Vidal , Andrade Alexandro , Keech Andrew , da Silva Valmir , Francisco Walker William , Milani Felipe Tiburcio , de Souza Genta Laura , Branco Braulio Henrique Magnani 
Published: November 2022

BACKGROUND: Moderate-intensity interval training (MIIT) may be a viable exercise format for improving body composition, aerobic fitness, and health-related variables. OBJECTIVES: This randomized trial aimed to analyze the effect of MIIT or high-intensity interval training (HIIT) on aerobic fitness, body composition variables, and resting metabolic rate (RMR) in women with overweight or obesity. METHODS: 31 sedentary adult women with overweight or obesity performed 7 weeks [Formula: see text] 3 weekly sessions of either HIIT or MIIT. Physical and physiological tests were applied before and after training. RESULTS: In both analyses (intention-to-treat and by adherence to the training), aerobic fitness showed a time effect ([Formula: see text] 0.041 and [Formula: see text] 0.015), but without differences between groups ([Formula: see text] 0.05). No group (HIIT vs. MIIT), time (pre vs. post), or interaction effects (group vs. time) were found for RMR, body composition markers (fat mass, body fat percentage, lean mass), or body mass index – BMI ([Formula: see text] 0.05). In addition, MIIT induced a relatively high drop-out rate. CONCLUSIONS: This study suggested that the short-term (7-weeks) interval exercise training was effective for increasing aerobic fitness, and moderate-intensity intervals were as effective as high-intensity intervals. However, neither training format was effective for changing RMR, body composition variables, or BMI of women with overweight or obesity. Clinical trial ID: RBR-9jd7b7.
Pathological (Dis)Similarities in Neuronal Exosome-Derived Synaptic and Organellar Marker Levels Between Alzheimer’s Disease and Frontotemporal Dementia
Authors: Krishna Geethu , Santhoshkumar Rashmi , Sivakumar Palanimuthu Thangaraju , Alladi Suvarna , Mahadevan Anita , Dahale Ajit B. , Arshad Faheem , Subramanian Sarada 
Published: November 2022

Background: Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are pathologically distinct neurodegenerative disorders with certain overlap in cognitive and behavioral symptoms. Both AD and FTD are characterized by synaptic loss and accumulation of misfolded proteins, albeit, in different regions of the brain. Objective: To investigate the synaptic and organellar markers in AD and FTD through assessment of the levels of synaptic protein, neurogranin (Ng) and organellar proteins, mitofusin-2 (MFN-2), lysosomal associated membrane protein-2 (LAMP-2), and golgin A4 from neuronal exosomes. Methods: Exosomes isolated from the plasma of healthy controls (HC), AD and FTD subjects were characterized using transmission electron microscopy. Neurodegenerative status was assessed by measurement of neurofilament light chain (NfL) using Simoa. The pooled exosomal extracts from each group were analyzed for Ng, MFN-2, LAMP-2, and golgin A4 by western blot analysis using enhanced chemiluminescence method of detection. Results: The densitometric analysis of immunoreactive bands demonstrated a 65% reduction of Ng in AD and 53% in FTD. Mitochondrial protein MFN-2 showed a significant reduction by 32% in AD and 46% in FTD. Lysosomal LAMP-2 and Golgi complex associated golgin A4 were considerably increased in both AD and FTD. Conclusion: Changes in Ng may reflect the ongoing synaptic degeneration that are linked to cognitive disturbances in AD and FTD. Importantly, the rate of synaptic degeneration was more pronounced in AD. Changes to a similar extent in both the dementia groups in organellar proteins indicates shared mechanisms of protein accumulation/degradation common to both AD and FTD.
Better understanding the life of the user to improve the design of orthopaedic footwear
Authors: van Dijk Lianne S. , Holtkamp Fred C. , Verkerk Maarten , Wouters Eveline J.M. 
Published: November 2022

BACKGROUND: A relatively high number of users is dissatisfied with their orthopaedic device. The term ‘user practice’ was introduced to emphasise the idea that users of orthopaedic devices perform activities within an environment, which are characteristic for that environment. OBJECTIVE: To investigate to what extend orthopaedic shoe engineers map the specific environments in which users live and the activities they perform within these environments during the first intake for custom made orthopaedic footwear. METHODS: Orthopaedic shoe engineers were recruited from orthopaedic service providers across The Netherlands. The intake with a new client for orthopaedic footwear was recorded and analysed using four user environments: daily life at home, transport, work, and leisure. RESULTS: Our study showed that orthopaedic shoe engineers cover at best less than 50% of activities within the four user environments. Consequently, there is no guarantee that the resulting design of the orthopaedic footwear fits all of the activities and environments of the users. CONCLUSIONS: The principles of user practices, consisting of specific environments and activities of the user, are not yet adequately used in the field of orthopaedic shoe engineering. By not using them, too little understanding of the life of the user can result in dissatisfaction and non-usage of the orthopaedic device.