bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the Use of Ozone Water as a Chemical Decontamination Agent for Antineoplastic Drugs in Clinical Settings
Authors: Kato Ginjiro , Mitome Hidemichi , Teshima Kenichiro , Tawa Kanako , Hakuba Yui , Tanabe Tomotaka , Funahashi Tatsuya , Hatae Noriyuki , Koike Yasumasa , Hasebe Masafumi , Hidaka Noriaki , Tanaka Mamoru , Akira Kazuki 
Published: November 2022

Abstract
The exposure of healthcare workers to antineoplastic drugs in hospitals has been recognized to be harmful. To minimize the risk of exposure, the removal of these drugs from work environments, such as compounding facilities, has been recommended. In our previous paper, the degradation and inactivation efficacy of ozone water, which is being introduced into Japanese hospitals as a chemical decontamination agent, was reported for its effects on typical antineoplastic drugs (gemcitabine, irinotecan, paclitaxel). This article aims to further investigate the efficacy of ozone water for eight antineoplastic drugs to clarify its application limitations. A small amount (medicinal ingredient: typically ca. 1.5 μmol) of formulation containing 5-fluorouracil, pemetrexed, cisplatin, oxaliplatin, cyclophosphamide, ifosfamide, doxorubicin, or docetaxel was mixed with 50 mL of ozone water (~8 mg/L), and the resulting solutions were analyzed by high-performance liquid chromatography over time to observe the degradation. Consequently, the ozonation was overall effective for the degradation of the drugs, however this varied depending on the chemical structures of the drugs and additives in their formulations. In addition, after the parent drugs were completely degraded by the ozonation, the degradation mixtures were subjected to 1H nuclear magnetic resonance spectroscopy and evaluated for mutagenicity against Salmonella typhimurium strains and cytotoxicity against human cancer cells. The degradation mixtures of cisplatin and ifosfamide were mutagenic while those of the other drugs were non-mutagenic. Further, the ozonation resulted in clear decreases of cytotoxicity for 5-fluorouracil, oxaliplatin, and doxorubicin, but increases of cytotoxicity for pemetrexed, cisplatin, cyclophosphamide, and ifosfamide. These results suggest that the ozone water should be restrictedly used according to the situation of contamination in clinical settings because the ozonation enhances toxicity depending on the drug even if degradation is achieved.
Interspecific variation in resistance and tolerance to herbicide drift reveals potential consequences for plant community co-flowering interactions and structure at the agro-eco interface
Authors: Iriart Veronica , Baucom Regina S , Ashman Tia-Lynn 
Published: November 2022

AbstractBackground and AimsWhen plant communities are exposed to herbicide ‘drift’, wherein particles containing the active ingredient travel off-target, interspecific variation in resistance or tolerance may scale up to affect community dynamics. In turn, these alterations could threaten the diversity and stability of agro-ecosystems. We investigated the effects of herbicide drift on the growth and reproduction of 25 wild plant species to make predictions about the consequences of drift exposure on plant–plant interactions and the broader ecological community.MethodsWe exposed potted plants from species that commonly occur in agricultural areas to a drift-level dose of the widely used herbicide dicamba or a control solution in the glasshouse. We evaluated species-level variation in resistance and tolerance for vegetative and floral traits. We assessed community-level impacts of drift by comparing the species evenness and flowering networks of glasshouse synthetic communities comprised of drift-exposed and control plants.Key ResultsSpecies varied significantly in resistance and tolerance to dicamba drift: some were negatively impacted while others showed overcompensatory responses. Species also differed in the way they deployed flowers over time following drift exposure. While drift had negligible effects on community evenness based on vegetative biomass, it caused salient differences in the structure of co-flowering networks within communities. Drift reduced the degree and intensity of flowering overlap among species, altered the composition of groups of species that were more likely to co-flower with each other than with others and shifted species roles (e.g. from dominant to inferior floral producers, and vice versa).ConclusionsThese results demonstrate that even low levels of herbicide exposure can significantly alter plant growth and reproduction, particularly flowering phenology. If field-grown plants respond similarly, then these changes would probably impact plant–plant competitive dynamics and potentially plant–pollinator interactions occurring within plant communities at the agro-ecological interface.
Increased Fat Graft Survival by Promoting Adipocyte Dedifferentiation
Authors: Chai Yimeng , Jia Xinyu , Zhu Jinglin , Jiang Chanyuan , Yin Ningbei , Li Facheng 
Published: November 2022

Abstract

Background
Some adipocytes undergo dedifferentiation after fat transplantation, and this may affect the survival of fat grafts. However, this effect has not been adequately studied.

Objectives
This study aimed to clarify the effect of promoting the dedifferentiation of mature adipocytes on the survival of fat grafts.

Methods
Mature adipocytes and adipose stem cells (ASCs) were treated with OSI-906 (a specific inhibitor of insulin receptor and insulin-like growth factor-1 receptor) in vitro, and then the dedifferentiation of mature adipocytes and the proliferation of ASCs were evaluated. In the in vivo experiment, human lipoaspirates mixed with phosphate-buffered saline (Group A) or OSI-906 (Group B) were compared in nude mice. Grafts were harvested at 2, 8, and 12 weeks, and volume retention rate, histologic, and immunohistochemical analyses were conducted.

Results
OSI-906 can promote the dedifferentiation of mature adipocytes and inhibit the proliferation of ASCs. At 12 weeks, Group B showed a better volume retention rate (mean [standard deviation, SD], 62.3% [7.61%]) than group A (47.75% [6.11%]) (P &lt; .05). Moreover, viable adipocytes and vascularization showed greater improvement in Group B than in Group A.

Conclusions
This study suggests that promoting the dedifferentiation of mature adipocytes can improve the survival rate and quality of fat grafts.
Perceiver CPI: a nested cross-attention network for compound–protein interaction prediction
Authors: Nguyen Ngoc-Quang , Jang Gwanghoon , Kim Hajung , Kang Jaewoo 
Published: November 2022

Abstract

Motivation
Compound–protein interaction (CPI) plays an essential role in drug discovery and is performed via expensive molecular docking simulations. Many artificial intelligence-based approaches have been proposed in this regard. Recently, two types of models have accomplished promising results in exploiting molecular information: graph convolutional neural networks that construct a learned molecular representation from a graph structure (atoms and bonds), and neural networks that can be applied to compute on descriptors or fingerprints of molecules. However, the superiority of one method over the other is yet to be determined. Modern studies have endeavored to aggregate information that is extracted from compounds and proteins to form the CPI task. Nonetheless, these approaches have used a simple concatenation to combine them, which cannot fully capture the interaction between such information.

Results
We propose the Perceiver CPI network, which adopts a cross-attention mechanism to improve the learning ability of the representation of drug and target interactions and exploits the rich information obtained from extended-connectivity fingerprints to improve the performance. We evaluated Perceiver CPI on three main datasets, Davis, KIBA and Metz, to compare the performance of our proposed model with that of state-of-the-art methods. The proposed method achieved satisfactory performance and exhibited significant improvements over previous approaches in all experiments.

Availability and implementation
Perceiver CPI is available at https://github.com/dmis-lab/PerceiverCPI.

Supplementary information
Supplementary data are available at Bioinformatics online.
Recruiting to surgical trials in the emergency setting: using a mixed methods study to understand clinician and patient perspectives
Authors: Twiddy Maureen , Birtwistle Jacqueline , Edmondson Amanda , Croft Julie , Gordon Kathryn , Meads David , Burke Dermot , Griffiths Ben , Rose Azmina , Sagar Peter , Stocken Deborah , Brown Julia M B , Harji Deena 
Published: November 2022

Abstract

Background
Undertaking randomized clinical trials (RCTs) in emergency surgical settings is associated with methodological and practical challenges. This study explored patients’ and clinicians’ perspectives associated with the conduct of an RCT comparing laparoscopic and open colorectal surgery in the acute setting.

Methods
All eligible patients screened and enrolled for the ‘Laparoscopic versus open colorectal surgery in the acute setting (LaCeS)’ multicentre, randomized clinical feasibility trial in five UK NHS Trusts were invited to respond to a survey. Patients and healthcare professionals were also invited to take part in semi-structured interviews. Survey and interviews explored the acceptability of the feasibility trial. Interviews were audio recorded, transcribed verbatim, and analysed using thematic analysis. Survey data were analysed descriptively to assess patient views of the trial and intervention.

Results
Out of 72 patients enrolled for the LaCeS RCT, survey data were collected from 28 patients (38.9 per cent), and interviews were conducted with 16 patients and 14 healthcare professionals. Thirteen out of 28 patients (46 per cent) had treatment preferences but these were not strong enough to deter participation. Twelve of the patients interviewed believed that their surgeon preferred laparoscopic surgery, but this did not deter them from participating in the trial. Half of the surgeons interviewed expressed the view that laparoscopic surgery was of benefit in this setting, but recognized that the need for research evidence outweighed their personal treatment preferences. Eight of the 14 recruiters reported that the emergency setting affected recruitment, especially in centres with fewer recruiting surgeons. Interviewees reported that recruitment was helped significantly by using surgical trainees to consent patients.

Conclusion
This study identified specific challenges for the LaCeS trial design to address and adds significant insights to our understanding of recruiting to emergency surgical trials more broadly.
The impact of hospital volume on survival in patients with locally advanced colonic cancer
Authors: Rosander Emma , Holm Torbjörn , Sjövall Annika , Hjern Fredrik , Weibull Caroline E , Nordenvall Caroline 
Published: November 2022

Abstract

Background
High hospital volume has been shown associated with improved survival in patients with several cancers. The aim of this nationwide cohort study was to investigate whether hospital volume affects survival in patients with locally advanced colonic cancer.

Methods
All patients with non-metastatic locally advanced colonic cancer diagnosed between 2007 and 2017 in Sweden were included. Tertiles of annual hospital volume of locally advanced colonic cancer were analysed and 5-year overall and colonic cancer-specific survival were calculated with the Kaplan–Meier method. HRs comparing all-cause and colonic cancer-specific mortality rates were estimated using Cox models adjusted for potential confounders (age, sex, year of diagnosis, co-morbidity, elective/emergency resection, and university hospital) and mediators (preoperative multidisciplinary team assessment, neoadjuvant chemotherapy, radical resection, and surgical experience).

Results
A total of 5241 patients were included with a mean follow-up of 2.7–2.8 years for low- and high-volume hospitals. The number of patients older than 79 years were 569 (32.3 per cent), 495 (29.9 per cent), and 482 (26.4 per cent) for low-, medium- and high-volume hospitals respectively. The 3-year overall survival was 68 per cent, 60 per cent and 58 per cent for high-, medium- and low-volume hospitals, respectively (P &lt; 0.001 from log rank test). High volume hospitals were associated with reduced all-cause and colon cancer-specific mortality after adjustments for potential confounders (HR 0.76, 95 per cent CI 0.62 to 0.93 and HR 0.73, 95 per cent CI 0.59 to 0.91, respectively). The effect remained after inclusion of potential mediators.

Conclusions
High hospital volume is associated with reduced mortality in patients with locally advanced colonic cancer.
Current evidence on posthepatectomy liver failure: comprehensive review
Authors: Sparrelid Ernesto , Olthof Pim B , Dasari Bobby V M , Erdmann Joris I , Santol Jonas , Starlinger Patrick , Gilg Stefan 
Published: November 2022

AbstractIntroductionDespite important advances in many areas of hepatobiliary surgical practice during the past decades, posthepatectomy liver failure (PHLF) still represents an important clinical challenge for the hepatobiliary surgeon. The aim of this review is to present the current body of evidence regarding different aspects of PHLF.MethodsA literature review was conducted to identify relevant articles for each topic of PHLF covered in this review. The literature search was performed using Medical Subject Heading terms on PubMed for articles on PHLF in English until May 2022.ResultsUniform reporting on PHLF is lacking due to the use of various definitions in the literature. There is no consensus on optimal preoperative assessment before major hepatectomy to avoid PHLF, although many try to estimate future liver remnant function. Once PHLF occurs, there is still no effective treatment, except liver transplantation, where the reported experience is limited.DiscussionStrict adherence to one definition is advised when reporting data on PHLF. The use of the International Study Group of Liver Surgery criteria of PHLF is recommended. There is still no widespread established method for future liver remnant function assessment. Liver transplantation is currently the only effective way to treat severe, intractable PHLF, but for many indications, this treatment is not available in most countries.
Reflection on modern methods: risk ratio regression—simple concept yet complex computation
Authors: Mittinty Murthy N , Lynch John 
Published: November 2022

AbstractThe risk ratio (RR) is the ratio of the outcome among the exposed to risk of the outcome among the unexposed. This is a simple concept, which makes one wonder why it has not gained the same popularity as the odds ratio. Using logistic regression to estimate the odds ratio is quite common in epidemiology and interpreting the odds ratio as a risk ratio, under the assumption that the outcome is rare, is also common. On one hand, estimating the odds ratio is simple but interpreting it is hard. On the other, estimating the risk ratio is challenging but its interpretation is straightforward. Issues with estimating risk ratio still remain after four decades. These issues include convergence of the algorithm, the choice of regression specification (e.g. log-binomial, Poisson) and many more. Various new computational methods are available which help overcome the issue of convergence and provide doubly robust estimates of RR.
Using Preference Estimates to Customize Incentives: An Application to Polio Vaccination Drives in Pakistan
Authors: Andreoni James , Callen Michael , Hussain Karrar , Khan Muhammad Yasir , Sprenger Charles 
Published: November 2022

Abstract
We use estimates of time preferences to customize incentives for polio vaccinators in Lahore, Pakistan. We measure time preferences using intertemporal allocations of effort, and use these estimates to construct individually tailored incentives. We evaluate the effect of matching contract terms to discounting parameters in a subsequent experiment with the same vaccinators. Our tailored policy is compared with alternatives that either rely on atheoretic reduced-form relationships for policy guidance or apply the same policy to all individuals. We find that contracts tailored to individual discounting outperform this range of policy alternatives.
Main Act or Side Show? Model Agreements by International Institutions and Their Reuse in Investment Treaty Texts
Authors: Alschner Wolfgang , Elsig Manfred , Wüthrich Simon 
Published: November 2022

ABSTRACT
Scholars and negotiators often assert that model treaty texts published by international institutions (IIs) shape investment treaty design. This paper empirically investigates the reuse of international institutions’ treaty templates. It tracks the imprint of six international institution templates on the text of negotiated international investment agreements (IIAs) using the Electronic Database of Investment Treaties. We find that the overall impact of international institution models has been low. No international investment agreement in our dataset was copied from an international institution’s model wholesale. On average, annual similarity between model texts and negotiated investment treaties is lower than 40% and significantly lower than the influence of international institutions’ models in the structurally similar international tax treaty regime. However, we do find evidence of an impact of international institutions' language on specific salient clauses. For example, the text of key investment protection clauses in the 1967 Draft Convention of the Organization of Economic Cooperation and Development was reproduced in hundreds of international investment agreements and novel clauses on investor responsibility first introduced in the 2006 International Institute for Sustainable Development model have subsequently been copied verbatim into negotiated international investment agreements. Our work concludes by discussing explanations for the comparatively low imprint of international institutions, notes other pathways for these institutions to influence treaty design, and sketches out an agenda for future research.
Digital Sequence Information between Benefit-Sharing and Open Data
Authors: Klünker Irma , Richter Heiko 
Published: November 2022

Abstract
Currently, parties to the Convention on Biological Diversity (CBD) are negotiating a strategic plan to save biodiversity. One crucial element of an agreement is the question of whether and how digital sequence information (DSI) is subject to access and benefit-sharing from the utilization of genetic resources, one main instrument of the CBD. In the EU, the Open Data Directive (ODD) of 2019 and the recently adopted Data Governance Act (DGA) already cover research data and to some extent DSI. An analysis of the ODD and the DGA throws a spotlight on the legal uncertainty of utilizing DSI and reveals systemic tensions between open data principles and benefit-sharing restrictions on non-commercial use. It also suggests that a future benefit-sharing mechanism for DSI should avoid distinguishing between commercial and non-commercial use upstream, but should instead favor a solution, which imposes benefit-sharing obligations further downstream or outside of the DSI life cycle.
Temperature-associated morphological changes in an African arid-zone ground squirrel
Authors: Warrington Miyako H , Waterman Jane 
Published: November 2022

Abstract
The ecology, life histories, and physiology of many animals are changing in response to human-induced climate change. As the Earth warms, the ability of an animal to thermoregulate becomes ecologically and physiologically significant. Morphological adaptations to warmer temperatures include larger appendages and smaller bodies. We examined morphological features in a ground squirrel, Xerus inauris, living in the arid zones of South Africa, to examine whether squirrels have responded to increases in temperature and changes in seasonal rainfall with morphological modifications over the last 18 years. We found that over time, absolute hindfoot length and proportional hindfoot length increased, while spine length decreased. These changes are consistent with ecogeographical rules (Allen’s rule and Bergmann’s rule) and provide evidence in support of “shape-shifting” in response to climatic warming. Body mass also increased with time; however, these changes were not consistent with Bergmann’s rule, indicating that mass is influenced by other ecological factors (e.g., resource availability). Our study adds to the growing evidence that animal morphologies are changing in response to changing climatic conditions, although it remains to be seen whether these changes are adaptive.
Calibration of the Tully–Fisher relation in the WISE W1 (3.4 μm) and W2 (4.6 μm) bands
Authors: Bell Rianna , Said Khaled , Davis Tamara , Jarrett T H 
Published: November 2022

ABSTRACT
In this paper, we present our calibrations of the Tully–Fisher relation in the mid-infrared W1 (3.4 $\mu$m) and W2 (4.6  $\mu$m) bands, using large samples of 877 galaxies and 876 galaxies from 31 clusters in the W1 and W2 bands, respectively. Using a new, iterative bivariate fitting procedure we performed two corrections, one for the cluster population incompleteness bias and a second morphological type correction. We initially performed calibrations using total absolute magnitudes and H i line widths WF50 derived from the H i global profiles as a measure of rotational velocity. We then used (i) isophotal magnitudes and (ii) average rotational velocities measured along the flat sections of the spatially resolved rotation curves of the galaxies, which were obtained from the empirical conversion between rotational velocity definitions. We determined that the calibrations using total magnitudes and H i line widths had smaller total scatter around the TF relations in the W1 and W2 bands than those using either isophotal magnitudes or spatially resolved rotational velocities. These calibrations are MTot,W1 = (1.77 ± 0.40) − (9.99 ± 0.16)log10(WF50) and MTot,W2 = (2.03 ± 0.40) − (10.12 ± 0.16)log10(WF50), with associated total scatters of σW1 = 0.66 and σW2 = 0.67. We compared these with previous calibrations in the near-infrared J, H, and K bands and the long-wavelength optical I band which used the same two corrections. The differences between calibrations can be explained by considering the different regions and components of spiral galaxies that are traced by the different wavelengths. The codes used for the calibrations of the Tully–Fisher relation are available from https://github.com/RiannaBell/WISE-TF-Calibration.
Search for LBVs in the Local Volume galaxies: study of two stars in NGC 1156
Authors: Solovyeva Y , Vinokurov A , Tikhonov N , Kostenkov A , Atapin K , Sarkisyan A , Moiseev A , Fabrika S , Oparin D , Valeev A 
Published: November 2022

ABSTRACT
We continue the search for luminous blue variables (LBVs) in Local Volume galaxies in order to study their fundamental parameters. In this paper, we report the discovery of two new LBVs in the dwarf irregular galaxy NGC 1156. Both stars exhibit spectral variability simultaneously with strong brightness variations: ΔRc = 0.84 ± 0.23m for J025941.21+251412.2 and ΔRc = 2.59 ± 0.10m for J025941.54+251421.8. The bolometric luminosities of the stars are in the range of LBol ≈ (0.8–1.6) × 106 L⊙. These values are corrected for reddening AV ≈ 0.9 and are given for the distance to the galaxy D = 7.0 ± 0.4 Mpc, which we have measured by the tip of the red-giant branch method. Both stars are above the Humphreys–Davidson limit in the region of relatively low temperatures, Teff ≲ 10 kK, on the temperature–luminosity diagram. J025941.54+251421.8 had a temperature below the hydrogen ionization threshold at maximum brightness, exhibiting behaviour very similar to that of the known LBV R71 during its 2012 outburst. We have estimated the masses of the detected LBVs and studied the properties of their stellar environment. We discuss our results within the framework of both a single star and a binary system evolution scenario for LBVs.