bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends of in-hospital cardiac arrests in a single tertiary hospital with a mature rapid response system
Authors: Jung Hohyung , Ko Ryoung-Eun , Ko Myeong Gyun , Jeon Kyeongman 
Published: January 2022

Background
Most studies on rapid response system (RRS) have simply focused on its role and effectiveness in reducing in-hospital cardiac arrests (IHCAs) or hospital mortality, regardless of the predictability of IHCA. This study aimed to identify the characteristics of IHCAs including predictability of the IHCAs as our RRS matures for 10 years, to determine the best measure for RRS evaluation.

Methods
Data on all consecutive adult patients who experienced IHCA and received cardiopulmonary resuscitation in general wards between January 2010 and December 2019 were reviewed. IHCAs were classified into three groups: preventable IHCA (P-IHCA), non-preventable IHCA (NP-IHCA), and inevitable IHCA (I-IHCA). The annual changes of three groups of IHCAs were analyzed with Poisson regression models.

Results
Of a total of 800 IHCA patients, 149 (18.6%) had P-IHCA, 465 (58.1%) had NP-IHCA, and 186 (23.2%) had I-IHCA. The number of the RRS activations increased significantly from 1,164 in 2010 to 1,560 in 2019 (P = 0.009), and in-hospital mortality rate was significantly decreased from 9.20/1,000 patients in 2010 to 7.23/1000 patients in 2019 (P = 0.009). The trend for the overall IHCA rate was stable, from 0.77/1,000 patients in 2010 to 1.06/1,000 patients in 2019 (P = 0.929). However, while the incidence of NP-IHCA (P = 0.927) and I-IHCA (P = 0.421) was relatively unchanged over time, the incidence of P-IHCA decreased from 0.19/1,000 patients in 2010 to 0.12/1,000 patients in 2019 (P = 0.025).

Conclusions
The incidence of P-IHCA could be a quality metric to measure the clinical outcomes of RRS implementation and maturation than overall IHCAs.
Asthma control and its predictors in Ethiopia: Systematic review and meta-analysis
Authors: Mulugeta Temesgen , Ayele Teshale , Zeleke Getandale , Tesfay Gebremichael 
Published: January 2022

BackgroundDetermining the status of asthma control and identifying risk factors for poor asthma control is a key strategy for curbing the negative health impacts and the financial burden of the disease. Therefore, this review was aimed to determine the rate of asthma control and assess the predictors of uncontrolled asthma in Ethiopia.MethodsPubMed, Web of Science, and Google Scholar searches were performed using key terms; “asthma, bronchial asthma, control, controlled, uncontrolled and Ethiopia” up to October 16, 2020. University repositories were also searched to retrieve gray literature. The results were presented as a prevalence rate with a 95% confidence interval (CI). Subgroup analysis and meta-regression were performed to identify the sources of heterogeneity in the outcomes.ResultsFrom 1,388 patients, based on the Global Initiative for Asthma (GINA) symptom control, the rate of the uncontrolled asthma was 45.0% (95% CI 34.0% - 56.0%) with a considerable heterogeneity between the studies; (I2: 94.55, p< 0.001). About 19.0% (95% CI 10.0% - 29.0%); (I2: 96.04, p< 0.001) of the asthma patients had a well-controlled asthma. Moreover, 36.0% (95% CI 22.0% - 50.0%), (I2: 97.11, p< 0.001) of patients had a partly controlled asthma. Similarly, based on the asthma control test (ACT), the rate of well-controlled asthma was 22.0% (95% CI 3% - 42.0%), with considerable heterogeneity between the studies; (I2: 97.75, p< 0.001). The most frequent predictors of uncontrolled asthma were incorrect inhalation techniques, frequent SABA use, moderate/severe persistent asthma, history of exacerbations, presence of comorbidities, use of oral corticosteroids, and irregular follow-up.ConclusionThe rate of uncontrolled asthma in Ethiopia was high. Several factors are associated with uncontrolled asthma. Comprehensive asthma educations at each follow-up visit should be strengthened to minimize the morbidity and the cost of uncontrolled asthma.
Prevalence and antimicrobial resistance pattern of Clostridium difficile among hospitalized diarrheal patients: A systematic review and meta-analysis
Authors: Dilnessa Tebelay , Getaneh Alem , Hailu Workagegnehu , Moges Feleke , Gelaw Baye 
Published: January 2022

Background
Clostridium difficile is the leading cause of infectious diarrhea that develops in patients after hospitalization during antibiotic administration. It has also become a big issue in community-acquired diarrhea. The emergence of hypervirulent strains of C. difficile poses a major problem in hospital-associated diarrhea outbreaks and it is difficult to treat. The antimicrobial resistance in C. difficile has worsened due to the inappropriate use of broad-spectrum antibiotics including cephalosporins, clindamycin, tetracycline, and fluoroquinolones together with the emergence of hypervirulent strains.

Objective
To estimate the pooled prevalence and antimicrobial resistance pattern of C. difficile derived from hospitalized diarrheal patients, a systematic review and meta-analysis was performed.

Methods
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed to review published studies conducted. We searched bibliographic databases from PubMed, Scopus, Google Scholar, and Cochrane Library for studies on the prevalence and antimicrobial susceptibility testing on C. difficile. The weighted pooled prevalence and resistance for each antimicrobial agent was calculated using a random-effects model. A funnel plot and Egger’s regression test were used to see publication bias.

Results
A total of 15 studies were included. Ten articles for prevalence study and 5 additional studies for antimicrobial susceptibility testing of C. difficile were included. A total of 1967/7852 (25%) C. difficile were isolated from 10 included studies for prevalence study. The overall weighted pooled proportion (WPP) of C. difficile was 30% (95% CI: 10.0–49.0; p<0.001). The analysis showed substantial heterogeneity among studies (Cochran’s test = 7038.73, I2 = 99.87%; p<0.001). The weighed pooled antimicrobial resistance (WPR) were: vancomycin 3%(95% CI: 1.0–4.0, p<0.001); metronidazole 5%(95% CI: 3.0–7.0, p<0.001); clindamycin 61%(95% CI: 52.0–69.0, p<0.001); moxifloxacin 42%(95% CI: 29–54, p<0.001); tetracycline 35%(95% CI: 22–49, p<0.001); erythromycin 61%(95% CI: 48–75, p<0.001) and ciprofloxacin 64%(95% CI: 48–80; p< 0.001) using the random effect model.

Conclusions
A higher weighted pooled prevalence of C. difficile was observed. It needs a great deal of attention to decrease the prevailing prevalence. The resistance of C. difficile to metronidazole and vancomycin was low compared to other drugs used to treat C. difficile infection. Periodic antimicrobial resistance monitoring is vital for appropriate therapy of C. difficile infection.
Characteristics of the gut microbiome in women with gestational diabetes mellitus: A systematic review
Authors: Rold Louise Søndergaard , Bundgaard-Nielsen Caspar , Niemann Holm-Jacobsen Julie , Glud Ovesen Per , Leutscher Peter , Hagstrøm Søren , Sørensen Suzette 
Published: January 2022

Background
The incidence of women developing gestational diabetes mellitus (GDM) is increasing, which is associated with an increased risk of type 2 diabetes mellitus (T2DM) for both mother and child. Gut microbiota dysbiosis may contribute to the pathogenesis of both GDM and the accompanying risk of T2DM. Thus, a better understanding of the microbial communities associated with GDM could offer a potential target for intervention and treatment in the future. Therefore, we performed a systematic review to investigate if the GDM women have a distinct gut microbiota composition compared to non-GDM women.

Methods
We identified 21 studies in a systematic literature search of Embase and PubMed up to February 24, 2021. Data on demographics, methodology and identified microbial metrics were extracted. The quality of each study was assessed according to the Newcastle-Ottawa Scale.

Results
Sixteen of the studies did find a GDM-associated gut microbiota, although no consistency could be seen. Only Collinsella and Blautia showed a tendency to be increased in GDM women, whereas the remaining genera were significantly different in opposing directions.

Conclusion
Although most of the studies found an association between GDM and gut microbiota dysbiosis, no overall GDM-specific gut microbiota could be identified. All studies in the second trimester found a difference between GDM and non-GDM women, indicating that dysbiosis is present at the time of diagnosis. Nevertheless, it is still unclear when the dysbiosis develops, as no consensus could be seen between the studies investigating the gut microbiota in the first trimester of pregnancy. However, studies varied widely concerning methodology and study design, which might explain the highly heterogeneous gut microbiota compositions between studies. Therefore, future studies need to include multiple time points and consider possible confounding factors such as ethnicity, pre-pregnancy body mass index, and GDM treatment.
Perinatal asphyxia and associated factors among neonates admitted to a specialized public hospital in South Central Ethiopia: A retrospective cross-sectional study
Authors: Mamo Seifu Awgchew , Teshome Girum Sebsibie , Tesfaye Tewodros , Goshu Abel Tibebu 
Published: January 2022

Introduction
Perinatal asphyxia continues to be a significant clinical concern around the world as the consequences can be devastating. World Health Organization data indicates perinatal asphyxia is encountered amongst 6–10 newborns per 1000 live full-term birth, and the figures are higher for low and middle-income countries. Nevertheless, studies on the prevalence of asphyxia and the extent of the problem in poorly resourced southern Ethiopian regions are limited. This study aimed to determine the magnitude of perinatal asphyxia and its associated factors.

Methods
A retrospective cross-sectional study design was used from March to April 2020. Data was collected from charts of neonates who were admitted to NICU from January 2016 to December 31, 2019.

Result
The review of 311 neonates’ medical records revealed that 41.2% of the neonates experienced perinatal asphyxia. Preeclampsia during pregnancy (AOR = 6.2, 95%CI:3.1–12.3), antepartum hemorrhage (AOR = 4.5, 95%CI:2.3–8.6), gestational diabetes mellitus (AOR = 4.2, 95%CI:1.9–9.2), premature rupture of membrane (AOR = 2.5, 95%CI:1.33–4.7) fetal distress (AOR = 3,95%CI:1.3–7.0) and meconium-stained amniotic fluid (AOR = 7.7, 95%CI: 3.1–19.3) were the associated factors.

Conclusion
Substantial percentages of neonates encounter perinatal asphyxia, causing significant morbidity and mortality. Focus on early identification and timely treatment of perinatal asphyxia in hospitals should, therefore, be given priority.
Anniversary of Edith Hinkley Quimby
Authors: Lushchikova A. P. , Chemshit A. I. 
Published: January 2022

At the beginning of the 20th century, the whole world was searching for radioactive substances application, in particular radium. Radium can be used to treat oncology, but no one knew the verge of overdosing and underdosing. The founder of radiobiology can be considered Lewis Gray, who introduced unit for absorbed dose of radiation [1]. It was Edith Quimby who started looking for that therapeutically effective absorbed dose. It’s to calculate the minimum effective dose of activity for each patient. She has written 75 articles, published books that have become used concepts in biophysics, and handbooks of modern editions of radiologists. She became the first woman and the first physicist to become president of the American Radium Society, an organization dedicated to the study and treatment of cancer. At one time, Arthur Compton spoke about the need to introduce and apply physics in medicine, and Quimby, in her acceptance speech, outlined the need for an organization of medical physicists, and in 1958, owing to her, the American Society of Medical Physicists was created. Edith Quimby was and remains an iconic figure in the history of the development of medical physics.
Studi tentang Pengaruh Kepuasan Pelanggan terhadap Ekuitas Merk dan Word of Mouth pada Bengkel AHASS Semarang Barat
Authors: Gunawan Eric , Sukresna I Made , Sugiono Sugiono 
Published: January 2022

Penelitian ini dilakukan dengan tujuan untuk melihat pengaruh Customer Satisfaction terhadap Brand Equity dan Word of Mouth pada bengkel AHASS. Variabel yang ditambahkan adalah Service Quality dan Perceived Price sebagai Moderating Variabel yang berpengaruh terhadap Customer Satisfaction.Sampel penelitian ini adalah para pelanggan Bengkel AHASS kota Semarang bagian Barat. Analisis data Structural Equation Model (SEM) menggunakan program software AMOSS dan SPSS. Hasil analisis menunjukkan bahwa Customer Satisfaction berpengaruh positif terhadap Brand Equity dan Word of Mouth. Service Quality berpengaruh positif terhadap Customer Satisfaction yang dimoderasi oleh Perceived Price sebagai Quasi Moderator.
The temporal and spatial scales of arable land loss and its impact in Guangxi, China: A Commentary
Authors: Feng Haiying , Squires Victor 
Published: January 2022

Cropland abandonment because of rural depopulation or policy interventions has become a key issue in Chinese mountainous areas. One such region is the Guangxi Karst Mountainous Area (GKMA), a zone where more than 59% of total land area is hilly and arable land of a commercially viable size is almost non-existent. The rugged terrain and land fragmentation in upland karst areas result in the scarcity of land suitable for cultivation. Although depopulation and declining agriculture since 2000 within the GKMA have led to vast areas of abandoned cropland, the spatiotemporal distribution that underlies this pattern as well as its causes remain little understood.
Geomorphic features also bring about differences in the distribution of settlements. Settlements with different degrees of distribution are accompanied by spatial differences in cultivated land resources, which lead to differences in the sufficiency of cultivated land resources. In this paper we provide an overview of the magnitude of the problem of arable land loss.
settlements and analyze the spatial distribution and the spatial agglomeration of the cultivated land.
A New General Equilibrium Welfare Measure, with Application to Labor Income Taxes
Authors: Mansoorian Arman , Michelis Leo , Angyridis Constantine 
Published: January 2022

Abstract
In this paper we extend the Hicksian compensating variation welfare measure in two directions. First, we adjust the size of the compensating variation in order to account for the fact that the compensating transfers will result in changes in output, as well as in prices, because labor and, in dynamic models, capital will adjust in response to these transfers. Second, we extend the measure to a dynamic setting with possibly time non-separable preferences. We find that these considerations become more significant for the welfare cost of higher labor income taxes as one moves from static to dynamic models, to models with time non-separable preferences, and finally to models with uncertainty.
Solving system of linear equations via bicomplex valued metric space
Authors: Gnanaprakasam Arul Joseph , Boulaaras Salah Mahmoud , Mani Gunaseelan , Cherif Bahri , Idris Sahar Ahmed 
Published: January 2022

Abstract
In this paper, we prove some common fixed point theorems on bicomplex metric space. Our results generalize and expand some of the literature’s well-known results. We also explore some of the applications of our key results.
Living Between: Exploring a Framework of Spirituality for Teachers and Students in Catholic Schools
Authors: Madden Rina 
Published: January 2022

Abstract
This paper proposes a focus on human experience as the locus of identity construction and meaning making and presents a dialogical framework of Christian spirituality as a heuristic for teacher professional learning in religious education in Australian Catholic schools. Firstly the paper explores spirituality as a growing area of interest for young people today and its relation to identity formation for teachers and students in Australian Catholic schools. Secondly it presents a relatable theological framework of spirituality as an opening to transformative dialogue and self-reflection. Finally it describes the four paradigms of spirituality of the framework and the curriculum possibilities they raise.
Discovery of Kerivoula kachinensis and a validity of K. titania (Chiroptera: Vespertilionidae) in China
Authors: Yu Wenhua , Lin Chuyan , Huang Zhenglanyi , Liu Shuo , Wang Qiaoyan , Quan Ruichang , Li Song , Wu Yi 
Published: January 2022

Abstract
In April 2019, 15 (10♂, 5♀) Kerivoula bats were collected by harp traps from Xishuangbanna, Yunnan Province, China. External and craniodental examination, multivariate statistical analyses and molecular phylogenetic inference (CoI, Cytb and Rag2 gene markers) indicated they are Kerivoula kachinensis and Kerivoula titania, respectively. Former represents a new chiropteran record from China, while the latter is a valid occurrence of K. titania in this region because recent study indicate a misidentification of “K. titania” in Guangdong, Guangxi and Hainan, China. All specimens are presently preserved at Key Laboratory of Conservation and Application in Biodiversity of South China in Guangzhou University, Guangzhou, China. Nowadays, four woolly bats occur in China including, Kerivoula furva, K. kachinensis, Kerivoula picta and K. titania, whilst there is a risk of underestimation the actual species diversity in China region when comparing those of neighboring region such as Vietnam. Supports for field survey need to be continued in future.
Tradition in Transition: Technology and Change in Archaeological Visualisation Practice
Authors: Opgenhaffen Loes 
Published: January 2022

Abstract
Archaeologists are the mediators between fragmented, and often contested, pasts and the momentary present. To record, organise, interpret, and reconstruct complex narratives of the past and to communicate these to present-day peers and the public, they use a wide range of visualisation methods. As such, visualisation methods form an intrinsic part of the representation of practical and intellectual findings, being crucial to knowledge production in archaeology. The adoption and adaptation of digital visualisation technology changes the way archaeologists shape new knowledge. However, for a discipline that is particularly concerned with how technology had an effect on past societies, for example, the impact of the potter’s wheel on local ceramic production strategies, archaeologists have a remarkably limited awareness of how current (digital) technology has an impact on their own visualisation practice and the subsequent knowledge production. This study presents the conceptual framework “tradition in transition,” which integrates technological and visualisation methodologies, and aims to provide a framework to analyse the underlying processes and mechanisms that shape and change the practice of creating visualisations.
Recent development of imidazole derivatives as potential anticancer agents
Authors: Kumar Naresh , Goel Nidhi 
Published: January 2022

Abstract
Cancer, one of the key health problems globally, is a group of related diseases that share a number of characteristics primarily the uncontrolled growth and invasive to surrounding tissues. Chemotherapy is one of the ways for the treatment of cancer which uses one or more anticancer agents as per chemotherapy regimen. Limitations of most anticancer drugs due to a variety of reasons such as serious side effects, drug resistance, lack of sensitivity and efficacy etc. generate the necessity towards the designing of novel anticancer lead molecules. In this regard, the synthesis of biologically active heterocyclic molecules is an appealing research area. Among heterocyclic compounds, nitrogen containing heterocyclic molecules has fascinated tremendous consideration due to broad range of pharmaceutical activity. Imidazoles, extensively present in natural products as well as synthetic molecules, have two nitrogen atoms, and are five membered heterocyclic rings. Because of their countless physiological and pharmacological characteristics, medicinal chemists are enthused to design and synthesize new imidazole derivatives with improved pharmacodynamic and pharmacokinetic properties. The aim of this present chapter is to discuss the synthesis, chemistry, pharmacological activity, and scope of imidazole-based molecules in anticancer drug development. Finally, we have discussed the current challenges and future perspectives of imidazole-based derivatives in anticancer drug development.
Synthesis, crystal-structure refinement and properties of bastnaesite-type PrF[CO3], SmF[CO3] and EuF[CO3]
Authors: Buyer Constantin , Schumacher Samira A. , Schleid Thomas 
Published: January 2022

Abstract
By adding a hot aqueous solution containing KF and K2[CO3] to another hot aquatic brine of Pr[NO3]3 ⋅ 5 H2O, Sm[NO3]3 ⋅ 5 H2O or Eu[NO3]3 ⋅ 5 H2O with a 1.3 times excess of the anion-providing solution, amorphous water-insoluble powders of PrF[CO3], SmF[CO3] and EuF[CO3] can be obtained. Through hydrothermal treatment at 210 °C for five days crystalline powders could be synthesized and their crystal structure was refined with Rietveld methods based on PXRD data. The named compounds crystallize in the bastnaesite-type structure with a = 710.912(12) pm, c = 976.811(6) pm for the praseodymium, a = 704.77(2) pm, c = 971.83(4) pm for the samarium and a = 700.734(6) pm, c = 969.066(8) pm for the europium compound, all hexagonal with Z = 6. Upon heating them, the compounds lose CO2 and fluoride oxides REFO emerge. Thermogravimetric experiments with crystalline samples show thermal stability up to 420 °C for PrF[CO3], 400 °C for SmF[CO3] and 340 °C for EuF[CO3], but decomposition below 200 °C for the amorphous ones. Infrared spectroscopy confirms only marginal portions of [OH]− instead of F− anions in all cases. The RE
3+ cations are coordinated by 9 + 2 anions at distances between 236 and 254 pm plus 326 pm to F− anions and oxygen atoms bonded to carbon as oxocarbonate anions [CO3]2−. Triggered by ultraviolet radiation, the bulk sample of EuF[CO3] shows a poor red luminescence.