bluuebunny/crossref_metadata_2025_split huggingface dataset:
Added value of 3T MRI and the MRI-halo sign in assessing resectability of locally advanced pancreatic cancer following induction chemotherapy (IMAGE-MRI): prospective pilot study
Authors: Stoop Thomas F. , van Veldhuisen Eran , van Rijssen L. Bengt , Klaassen Remy , Gurney-Champion Oliver J. , de Hingh Ignace H. , Busch Olivier R. , van Laarhoven Hanneke W. M. , van Lienden Krijn P. , Stoker Jaap , Wilmink Johanna W. , Nio C. Yung , Nederveen Aart J. , Engelbrecht Marc R. W. , Besselink Marc G. ,   IMAGE study group, Bosscha Koop , Nieuwehof-Biesheuvel Loes van den , Marsman Hendrik A. , Seelen Leonard W. F. 
Published: October 2022

Abstract

Background
Restaging of locally advanced pancreatic cancer (LAPC) after induction chemotherapy using contrast-enhanced computed tomography (CE-CT) imaging is imprecise in evaluating local tumor response. This study explored the value of 3 Tesla (3 T) contrast-enhanced (CE) and diffusion-weighted (DWI) magnetic resonance imaging (MRI) for local tumor restaging.

Methods
This is a prospective pilot study including 20 consecutive patients with LAPC with RECIST non-progressive disease on CE-CT after induction chemotherapy. Restaging CE-CT, CE-MRI, and DWI-MRI were retrospectively evaluated by two abdominal radiologists in consensus, scoring tumor size and vascular involvement. A halo sign was defined as replacement of solid perivascular (arterial and venous) tumor tissue by a zone of fatty-like signal intensity.

Results
Adequate MRI was obtained in 19 patients with LAPC after induction chemotherapy. Tumor diameter was non-significantly smaller on CE-MRI compared to CE-CT (26 mm vs. 30 mm; p = 0.073). An MRI-halo sign was seen on CE-MRI in 52.6% (n = 10/19), whereas a CT-halo sign was seen in 10.5% (n = 2/19) of patients (p = 0.016). An MRI-halo sign was not associated with resection rate (60.0% vs. 62.5%; p = 1.000). In the resection cohort, patients with an MRI-halo sign had a non-significant increased R0 resection rate as compared to patients without an MRI-halo sign (66.7% vs. 20.0%; p = 0.242). Positive and negative predictive values of the CE-MRI-halo sign for R0 resection were 66.7% and 66.7%, respectively.

Conclusions
3 T CE-MRI and the MRI-halo sign might be helpful to assess the effect of induction chemotherapy in patients with LAPC, but its diagnostic accuracy has to be evaluated in larger series.
Neuroendocrine neoplasms of the breast: diagnostic agreement and impact on outcome
Authors: Metovic Jasna , Cascardi Eliano , Uccella Silvia , Maragliano Roberta , Querzoli Giulia , Osella-Abate Simona , Pittaro Alessandra , La Rosa Stefano , Bogina Giuseppe , Cassoni Paola , Marchiò Caterina , Sapino Anna , Castellano Isabella , Papotti Mauro 
Published: October 2022

Abstract
The classification of breast neuroendocrine neoplasms (Br-NENs) was modified many times over the years and is still a matter of discussion. In the present study, we aimed to evaluate the diagnostic reproducibility and impact on patient outcomes of the most recent WHO 2019 edition of breast tumor classification, namely, for neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs). This multicentric observational study included 287 breast neoplasms with NE differentiation. The cases were blindly classified by three independent groups of dedicated breast and/or endocrine pathologists following the 2019 guidelines. Diagnostic concordance and clinical impact were assessed. We observed only a moderate overall diagnostic agreement across the three centers (Cohen’s kappa 0.4532) in distinguishing NET from solid papillary carcinomas (SPCs) and no special type carcinomas (NST) with NE differentiation. Br-NENs were diagnosed in 122/287 (42.5%) cases, subclassified as 11 NET G1 (3.8%), 84 NET G2 (29.3%), and 27 NEC (9.4%), the latter group consisting of 26 large-cell and 1 small-cell NECs. The remaining 165/287 (57.5%) cases were labeled as non-NEN, including SPC, mucinous, NST, and mixed NE carcinomas. While NET and non-NEN cases had a comparable outcome, the diagnosis of NECs showed negative impact on disease-free interval compared to NETs and non-NENs (p = 0.0109). In conclusion, the current diagnostic classification of Br-NENs needs further adjustments regarding morphological and immunohistochemical criteria to increase the diagnostic reproducibility among pathologists. Our data suggest that, apart from high-grade small- and large-cell NECs, Br-NENs behave like non-NEN breast carcinomas and should be managed similarly.
JAK2V617F variant allele frequency, non-driver mutations, single-nucleotide variants and polycythemia vera outcome
Authors: Kanduła Zuzanna , Janowski Michał , Więckowska Barbara , Paczkowska Edyta , Lewandowski Krzysztof 
Published: October 2022

Abstract
Introduction
Despite comparatively favourable prognosis in polycythemia vera (PV) patients (pts), the overall survival is shorter compared to the age-matched general population. The aim of the study was to evaluate the impact of chosen laboratory and genetic factors on the individual disease outcome, i.e. risk of thrombosis, myelofibrosis/blastic transformation and death.

Materials and methods
The study group consisted of 151 pts and 57 healthy donors (HD).

Results
JAK2V617F mutation was found in 96.7% (146/151) of the studied pts. JAK2 exon 12 mutations were identified in 2 individuals. The coexistence of JAK2V617F and JAK2 exon 12 mutation was confirmed in 2 other pts. In one case, neither JAK2V617F nor JAK2 exon 12 mutation was found. The presence of ten different non-driver mutations (ASXL1, SRSF2, U2AF1, IDH2) in eight of the analyzed pts (5.3%) was confirmed. The overall frequency of thrombotic events (TE) in the studied PV group was 23.8% (36/151). In patients with TE, median platelet count was lower than in pts without TE. Thrombotic risk did not depend on JAK2 rs12343867, TERT rs2736100, OBFC1 rs9420907 SNV, however, we found a novel strong tendency towards statistical significance between the CC genotype miR-146a rs2431697 and thrombosis. The disease progression to fibrotic phase was confirmed in 9% of the pts. Fibrotic transformation in PV pts was affected mainly by JAK2V617F variant allele frequency (VAF) and the presence of coexisting non-driver variants. The high JAK2V617F VAF and elevated white blood cell (WBC) count at the time of diagnosis were associated with an increased risk of death.

Conclusion
Therefore, in our opinion, complex, laboratory and genetic PV pts evaluation at the time of diagnosis should be incorporated into a new prognostic scoring system to more precisely define the PV prognosis and to optimize the therapeutic decision-making process.
The missing piece of the puzzle: larval morphology of Xenohyla truncata (Anura: Hylidae: Dendropsophini) and its implication to the evolution of Dendropsophini tadpoles
Authors: dos Santos Dias Pedro Henrique , Marcondes Bárbara Caroline , Pezzuti Tiago Leite , Vera Candioti Florencia , Araujo-Vieira Katyuscia , Mela Prodocimo Maritana , da Silva Hélio Ricardo , Orrico Victor Goyannes Dill , Haas Alexander 
Published: October 2022

AbstractDendropsophini is a highly diverse clade with a controversial phylogenetic and taxonomic history. Different generic arrangements have been proposed and the monophyly of several clades supported or rejected. Previous evidence suggested that larval morphology could play an important role in our understanding of the evolution and diversification of Dendropsophini, although data are missing for most lineages, including the sister group of Dendropsophus, Xenohyla. Herein we describe the internal morphology of the tadpoles of X. truncata and compare our results with available information for members of Dendropsophini and closely related lineages. We propose that the presence of a fan-like papilla in the buccopharyngeal cavity, a single element suprarostral, and a triangular process at the base of the muscular process are synapomorphies for Dendropsophini; moreover, the presence of a divided m. subarcualis rectus II–IV seems to be a synapomorphy for Pseudini and, the nasal sac insertion of the m. levator lateralis could be a synapomorphy of Dendropsophini + Pseudini.
5-ALA fluorescence in randomly selected pediatric brain tumors assessed by spectroscopy and surgical microscope
Authors: Milos Peter , Haj-Hosseini Neda , Hillman Jan , Wårdell Karin 
Published: October 2022

Abstract
Purpose
Fluorescence-guided surgery applying 5-aminolevulinic acid (5-ALA) in high-grade gliomas is an established method in adults. In children, results have so far been ambiguous. The aim of this study was to investigate 5-ALA-induced fluorescence in pediatric brain tumors by using the surgical microscope and a spectroscopic hand-held probe.

Methods
Fourteen randomly selected children (age 4–17) with newly MRI-verified brain tumors were included. No selection was based on the suspected diagnosis prior to surgery. All patients received 5-ALA (20 mg /kg) either orally or via a gastric tube prior to surgery. Intratumoral fluorescence was detected with the microscope and the probe. Moreover, fluorescence in the skin of the forearm was measured. Histopathology samples revealed seven low-grade gliomas, four medulloblastomas, one diffuse intrinsic pontine glioma, one glioblastoma and one atypical meningioma. Blood samples were analyzed, and potential clinical side effects were monitored.

Results
Microscopically, vague fluorescence was visible in two patients. Intratumoral fluorescence could be detected in five patients with the probe, including the two patients with vague microscopic fluorescence. Three of the oldest children had PpIX fluorescence in the skin. Nine children did not show any fluorescence in the tumor or in the skin. No clinical side effects or laboratory adverse events were observed.

Conclusion
Fluorescence could not be used to guide surgery in this study, neither with the surgical microscope nor with the hand-held probe. In nine children, no fluorescence was discerned and children with noticeable fluorescence were all older than nine years. 5-ALA was considered safe to apply in children.
Robust and scalable content-and-structure indexing
Authors: Wellenzohn Kevin , Böhlen Michael H. , Helmer Sven , Pietri Antoine , Zacchiroli Stefano 
Published: October 2022

AbstractFrequent queries on semi-structured hierarchical data are Content-and-Structure (CAS) queries that filter data items based on their location in the hierarchical structure and their value for some attribute. We propose the Robust and Scalable Content-and-Structure (RSCAS) index to efficiently answer CAS queries on big semi-structured data. To get an index that is robust against queries with varying selectivities, we introduce a novel dynamic interleaving that merges the path and value dimensions of composite keys in a balanced manner. We store interleaved keys in our trie-based RSCAS index, which efficiently supports a wide range of CAS queries, including queries with wildcards and descendant axes. We implement RSCAS as a log-structured merge tree to scale it to data-intensive applications with a high insertion rate. We illustrate RSCAS’s robustness and scalability by indexing data from the Software Heritage (SWH) archive, which is the world’s largest, publicly available source code archive.
AI-big data analytics for building automation and management systems: a survey, actual challenges and future perspectives
Authors: Himeur Yassine , Elnour Mariam , Fadli Fodil , Meskin Nader , Petri Ioan , Rezgui Yacine , Bensaali Faycal , Amira Abbes 
Published: October 2022

AbstractIn theory, building automation and management systems (BAMSs) can provide all the components and functionalities required for analyzing and operating buildings. However, in reality, these systems can only ensure the control of heating ventilation and air conditioning system systems. Therefore, many other tasks are left to the operator, e.g. evaluating buildings’ performance, detecting abnormal energy consumption, identifying the changes needed to improve efficiency, ensuring the security and privacy of end-users, etc. To that end, there has been a movement for developing artificial intelligence (AI) big data analytic tools as they offer various new and tailor-made solutions that are incredibly appropriate for practical buildings’ management. Typically, they can help the operator in (i) analyzing the tons of connected equipment data; and; (ii) making intelligent, efficient, and on-time decisions to improve the buildings’ performance. This paper presents a comprehensive systematic survey on using AI-big data analytics in BAMSs. It covers various AI-based tasks, e.g. load forecasting, water management, indoor environmental quality monitoring, occupancy detection, etc. The first part of this paper adopts a well-designed taxonomy to overview existing frameworks. A comprehensive review is conducted about different aspects, including the learning process, building environment, computing platforms, and application scenario. Moving on, a critical discussion is performed to identify current challenges. The second part aims at providing the reader with insights into the real-world application of AI-big data analytics. Thus, three case studies that demonstrate the use of AI-big data analytics in BAMSs are presented, focusing on energy anomaly detection in residential and office buildings and energy and performance optimization in sports facilities. Lastly, future directions and valuable recommendations are identified to improve the performance and reliability of BAMSs in intelligent buildings.
Impacts of slurry acidification and injection on fertilizer nitrogen fates in grassland
Authors: Schreiber Mirella , Bazaios Elpida , Ströbel Barbara , Wolf Benjamin , Ostler Ulrike , Gasche Rainer , Schlingmann Marcus , Kiese Ralf , Dannenmann Michael 
Published: October 2022

AbstractLow nitrogen (N) use efficiency of broadcast slurry application leads to nutrient losses, air and water pollution, greenhouse gas emissions and—in particular in a warming climate—to soil N mining. Here we test the alternative slurry acidification and injection techniques for their mitigation potential compared to broadcast spreading in montane grassland. We determined (1) the fate of 15N labelled slurry in the plant-soil-microbe system and soil-atmosphere exchange of greenhouse gases over one fertilization/harvest cycle and (2) assessed the longer-term contribution of fertilizer 15N to soil organic N formation by the end of the growing season. The isotope tracing approach was combined with a space for time climate change experiment. Simulated climate change increased productivity, ecosystem respiration, and net methane uptake irrespective of management, but the generally low N2O fluxes remained unchanged. Compared to the broadcast spreading, slurry acidification showed lowest N losses, thus increased productivity and fertilizer N use efficiency (38% 15N recovery in plant aboveground plant biomass). In contrast, slurry injection showed highest total fertilizer N losses, but increased fertilization-induced soil organic N formation by 9–12 kg N ha−1 season−1. Slurry management effects on N2O and CH4 fluxes remained negligible. In sum, our study shows that the tested alternative slurry application techniques can increase N use efficiency and/or promote soil organic N formation from applied fertilizer to a remarkable extent. However, this is still not sufficient to prevent soil N mining mostly resulting from large plant N exports that even exceed total fertilizer N inputs.
Nitrogen fertilization with pig slurry in a barley-sorghum double-annual forage cropping system
Authors: Ovejero J. , Maresma A. , Marks E. A. N. , Ortiz C. , Boixadera J. , Serra X. , Ponsá S. , Lloveras J. , Casas C. 
Published: October 2022

AbstractThe high concentration of pig farms in NE Spain makes pig slurries an attractive fertilizer to reduce costs of agricultural production. However, inadequate management of fertilization with pig slurry can cause negative environmental consequences. In this context, a 4 year field trial was carried out to evaluate several fertilization strategies, using pig slurry, for a double-annual forage cropping rotation with barley (Hordeum vulgare L.) and sorghum (Sorghum bicolor L.) under sub-humid Mediterranean conditions. Four nitrogen (N) fertilization treatments applied as pig slurry (0, 170, 250 and 330 kg N ha−1 year−1) were applied and their effects on yield, N uptake, unrecovered N, and residual NO3-N in soil were evaluated for each crop and each rotation. The 4 year average dry matter (DM) forage yield of sorghum was 9.3 Mg ha−1 in all N fertilization treatments, except for the control (0 kg N ha−1) which was 6 Mg ha−1. However, barley DM yields varied among N treatments. The highest barley yield (8.7 Mg DM ha−1) was achieved with the application of 330 kg N ha−1 year−1. The barley yields were reduced by a 26% (6.9 Mg DM ha−1) and a 64% (5.3 Mg DM ha−1) with N rates of 250 and 170 kg N ha−1 year−1, respectively. The average total annual yield was 17.8 Mg DM ha−1 for the maximum N rate tested (330 kg N ha−1 year−1). Indeed, the application of N rates above the maximum amount allowed by the Nitrates Directive in areas vulnerable to nitrate contamination (NVZ) (170 kg N ha−1 year−1 in form of pig slurry), improved the total annual DM yield by 10–18%. However, N rates of 250 kg N ha−1 year−1 increased by 69% the unrecovered N compared to applying 170 kg N ha−1 year−1. This could lead to N losses to the environment, probably by nitrate leaching and/or volatilization.
Almost every path structure is not variational
Authors: Kruglikov Boris S. , Matveev Vladimir S. 
Published: October 2022

AbstractGiven a smooth family of unparameterized curves such that through every point in every direction there passes exactly one curve, does there exist a Lagrangian with extremals being precisely this family? It is known that in dimension 2 the answer is positive. In dimension 3, it follows from the work of Douglas that the answer is, in general, negative. We generalise this result to all higher dimensions and show that the answer is actually negative for almost every such a family of curves, also known as path structure or path geometry. On the other hand, we consider path geometries possessing infinitesimal symmetries and show that path and projective structures with submaximal symmetry dimensions are variational. Note that the projective structure with the submaximal symmetry algebra, the so-called Egorov structure, is not pseudo-Riemannian metrizable; we show that it is metrizable in the class of Kropina pseudo-metrics and explicitly construct the corresponding Kropina Lagrangian.
Combining hybrid genetic search with ruin-and-recreate for solving the capacitated vehicle routing problem
Authors: Simensen Martin , Hasle Geir , Stålhane Magnus 
Published: October 2022

AbstractThe Capacitated Vehicle Routing Problem (CVRP) has been subject to intense research efforts for more than sixty years. Yet, significant algorithmic improvements are still being made. The most competitive heuristic solution algorithms of today utilize, and often combine, strategies and elements from evolutionary algorithms, local search, and ruin-and-recreate based large neighborhood search. In this paper we propose a new hybrid metaheuristic for the CVRP, where the education phase of the hybrid genetic search (HGS) algorithm proposed by (Vidal Hybrid Genetic Search for the CVRP: Open-Source Implementation and SWAP* Neighborhood 2020) is extended by applying large neighborhood search (LNS). By performing a series of computational experiments, we attempt to answer the following research questions: 1) Is it possible to gain performance by adding LNS as a component in the education phase of HGS? 2) How does the addition of LNS change the relative importance of the local search neighborhoods of HGS? 3) What is the effect of devoting computational efforts to the creation of an elite solution in the initial population of HGS? Through a set of computational experiments we answer these research questions, while at the same time obtaining a good configuration of global parameter settings for the proposed heuristic. Testing the heuristic on benchmark instances from the literature with limited computing time, it outperforms existing algorithms, both in terms of the final gap and the primal integral.
Mapping and Extending the Theoretical Perspectives of Reading in Science and Mathematics Education Research
Authors: Tang Kok-Sing , Lin Sheau-Wen , Kaur Berinderjeet 
Published: October 2022

Abstract
This introductory paper to the special issue “Reading in Science and Mathematics” presents four major theoretical perspectives of reading, literacy, and language that underpin many studies in this area, including the nine articles selected for this issue. It first outlines several new developments and contemporary issues that drive the growing importance of reading in science and mathematics. It then presents the perspectives that inform and situate the authors’ research as reported in this special issue, followed by a brief introduction of their articles situated within each of the perspectives. The four perspectives are reading comprehension, scientific/mathematical literacy, disciplinary literacy, and linguistic/semiotic meaning-making. The purpose in discussing these perspectives is to map out the theoretical terrain in the field and connect the key ideas within the research on reading in science and mathematics.
Gendered Science Practice at Secondary School and its Effects on Science Motivations
Authors: Kang Jingoo 
Published: October 2022

Abstract
This study explores the effects of gendered inquiry-based learning (IBL) practices on other science learning experiences and motivations including STEM (Science, Technology, Engineering, and Mathematics) career aspirations. For this, PISA 2015 data representing the Finnish 15-year-old student population has been selected and analyzed by multiple group structural equation modeling. According to the results, while girls and boys perceived a similar frequency of conducting IBL at school as a student, boys were more aware that students were allowed to conduct high autonomous IBL activities such as designing their own experiments. Also, boys expressed that they got more feedback from their teachers, and it was moderately related to the IBL engagement. Moreover, the result showed that while boys perceived more IBL experiences, the efficacy of the IBL activities was higher for girls since the relationship between IBL and science motivations was stronger for girls compared to boys. Lastly, this study found that a teacher was more prone to undervalue girls’ science performance than boys during IBL. Based on the findings, this study argues that school IBL practices could be a good source for examining gender equity in science education. Also, the findings recommend gender-inclusive science practices at school in order to increase girls’ interest in STEM careers and to enhance the effects of IBL on students’ science achievement.