bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating metabolites associated with incident myocardial infarction and stroke: A prospective cohort study of 90 438 participants
Authors: Guo Yu , Chen Shu‐Fen , Zhang Ya‐Ru , Wang Hui‐Fu , Huang Shu‐Yi , Chen Shi‐Dong , Deng Yue‐Ting , Wu Bang‐Sheng , Kuo Kevin , Wang Rong‐Ze , Dong Qiang , Feng Jian‐Feng , Cheng Wei , Yu Jin‐Tai 
Published: June 2022

AbstractThe relevance between circulating metabolites and vascular events remains controversial and comprehensive studies are lacking. We sought to investigate the prospective associations of plasma metabolomics with risks of incident stroke, ischemic stroke (IS), hemorrhagic stroke (HS), and myocardial infarction (MI). Within the UK Biobank cohort, 249 circulating metabolites were measured in 90 438 participants without baseline vascular diseases. Cox proportional hazards regressions were applied to estimate adjusted hazard ratios (HRs) for per 1 standard deviation increment in metabolites. The least absolute shrinkage and selection operator algorithm was used for selecting metabolite subsets. During a median of 9.0 years of follow‐up, we documented 833 incident stroke and 1256 MI cases. Lipid constituents, comprising cholesterol, cholesteryl esters, free cholesterol, phospholipids, and total lipids, in very low‐ (VLDL), intermediate‐ (IDL), and low‐density lipoprotein (LDL) particles were positively associated with MI risk (HR = 1.12 to 1.36; 95% CI = 1.06 to 1.44), while in high‐density lipoprotein (HDL) particles showed inverse associations (HR = 0.68 to 0.81; 95% CI = 0.63 to 0.87). Similar association pattern with MI was also observed for VLDL, IDL, LDL, and HDL particles themselves. In contrast, triglycerides within all lipoproteins, including most HDL particles, were positively associated with MI risk (HR = 1.14 to 1.28; 95% CI = 1.08 to 1.35) and, to a slightly lesser extent, with stroke and IS. Unsaturation of fatty acids and albumin were inversely associated with risks of stroke, IS, and MI. In contrast, the linear association for HS is absent. When combining multiple metabolites, the metabolite risk score captured a drastically elevated risk of all vascular events, about twice that of any single metabolite. Taken together, circulating metabolites showed remarkably widespread associations with incident MI, but substantially weakened associations with risks of stroke and its subtypes. Exhaustive metabolomics profiling may shed light on vascular risk prediction and, in turn, guide pertinent strategies of intervention and treatment.image
Efficacy of alpha hydroxy acid combined with intense pulsed light in the treatment of acne vulgaris: A meta‐analysis
Authors: Huang Qiao , Chen Dongyu , Pan Suyue , Hu Min , Wang Pu , Wang Hongxin , Fan Wenlong , Yang Xiaoyu , He Yuqing 
Published: June 2022

AbstractBackgroundAcne patients frequently receive combination therapy. However, there has been no rigorous review of the efficacy of combining alpha hydroxy acid with IPL for acne vulgaris treatment.ObjectiveAssessing the effectiveness and safeness of alpha hydroxy acids in combination with IPL in the treatment of people with acne vulgaris.MethodsA computer search of common biomedical databases, including PubMed, Web of Science, Cochrane Library, Embase, Wanfang, CNKI, SinoMed, and VIP, was extensively conducted to identify previous studies on randomized controlled trials of alpha hydroxy acid combined with IPL in the management of acne vulgaris.ResultsA total of 18 publications were included (1435 patients with common acne met the inclusion criteria). The meta‐analysis showed that alpha hydroxy acid (AHA) combined with IPL had higher overall efficacy than the control group (OR = 4.24; 95% CI 2.66 ~ 6.74; p < 0.01). In the case of acne vulgaris, AHA combined with IPL and the AHA alone showed a remarkable difference in total efficiency (OR = 4.10; 95% CI 2.12 ~ 7.91; p < 0.01), and AHA combined with IPL were more effective than IPL alone (OR = 4.02; 95% CI 2.25 ~ 7.16; p < 0.01). In addition, the occurrence of adverse reactions that occurred in AHA combined with IPL and control groups did not differ (OR = 0.86; 95% CI 0.46 ~ 1.60; p = 0.64).ConclusionAHA combined with IPL therapy was superior to other therapies. Although it was slightly more expensive, it was effective and had a wide range of applications.
From ambivalence to vulnerability: Recognition and the subject
Authors: Schick Kate 
Published: June 2022

AbstractRecent writings on recognition and ambivalence highlight the limits of narrowly dyadic and teleological accounts of recognition. In this article, I extend the work on ambivalent recognition by proffering a conception of recognition as vulnerable. I emphasise the need to come to know the self as part of the journey toward recognition and to interrogate the role of the privileged in the dance of recognition. I illustrate vulnerable recognition with reference to literature that highlights this more complicated reading of recognition in practice, including calls for white settlers to come to understand the way settler culture shapes relations with others and Indigenous refusal of recognition. I maintain that a vulnerable and processual conception of recognition takes seriously the demand to re‐cognise or to ‘know again’, which is at the heart of Hegel's agonistic account of recognition. A vulnerable conception of recognition enables us to better understand our interconnectedness and the place we occupy in particular histories and structures, with their ongoing legacies of privilege and oppression.
What can cold‐induced transcriptomes of Arctic Brassicaceae tell us about the evolution of cold tolerance?
Authors: Birkeland Siri , Slotte Tanja , Krag Brysting Anne , Gustafsson A. Lovisa S. , Rhoden Hvidsten Torgeir , Brochmann Christian , Nowak Michael D. 
Published: June 2022

AbstractLittle is known about the evolution of cold tolerance in polar plant species and how they differ from temperate relatives. To gain insight into their biology and the evolution of cold tolerance, we compared the molecular basis of cold response in three Arctic Brassicaceae species. We conducted a comparative time series experiment to examine transcriptional responses to low temperature. RNA was sampled at 22°C, and after 3, 6, and 24 at 2°C. We then identified sets of genes that were differentially expressed in response to cold and compared them between species, as well as to published data from the temperate Arabidopsis thaliana. Most differentially expressed genes were species‐specific, but a significant portion of the cold response was also shared among species. Among thousands of differentially expressed genes, ~200 were shared among the three Arctic species and A. thaliana, while ~100 were exclusively shared among the three Arctic species. Our results show that cold response differs markedly between Arctic Brassicaceae species, but probably builds on a conserved basis found across the family. They also confirm that highly polygenic traits such as cold tolerance may show little repeatability in their patterns of adaptation.
Economic security of Ukraine: Management aspect through the prism of socio‐economic development in the context of international ratings
Authors: Somych Mykola , Opaliuk Tetiana , Potapiuk Iryna , Ovcharuk Elena , Oliinyk Alina 
Published: June 2022

AbstractRecent studies focus on a new model of global process management formation and transformation. The purpose of this article is to reveal and analyze the level of economic security in Ukraine, argue the interdependence of socio‐economic development and economic security, and suggest possible ways to improve the state of things. The analysis is carried out on the basis of reliable statistical data and through the prism of the following global indices: Human Development Index, Social Progress Index, World Happiness Report, Global Innovation Index, Index of Economic Freedom, Corruption Perceptions Index. This article considers the impact of international indices of social‐economic status on economic security (the case study concerns the period of 2010–2018). The multifactor correlation‐regression analysis allows the assessment of the degree of social‐economic status indices' influence on the output results. The key findings of the study provide recommendations, the implementation of which will help Ukraine to strengthen its positions.Related ArticlesBochsler, Daniel. 2009. “Are Mixed Electoral Systems the Best Choice for Central and Eastern Europe or the Reason for Defective Party Systems?” Politics & Policy 37(4): 735–67. https://doi.org/10.1111/j.1747‐1346.2009.00196.x.Kilinç‐Pala, and Pinar Buket. 2021. “Approaches in Energy Exclusive Security: Theories of Energy Security and the Dominance of Realism.” Politics & Policy 49(3): 771–94. https://doi.org/10.1111/polp.12411.Kostadinova, Tatiana. 2009. “Abstain or Rebel: Corruption Perceptions and Voting in East European Elections.” Politics & Policy 37(4): 691–714. https://doi.org/10.1111/j.1747‐1346.2009.00194.x.
Attention to climate change and downside risk: Evidence from China
Authors: Chen Xing , Chen Xian , Xu Longhao , Wen Fenghua 
Published: June 2022

AbstractWe explore the role of public climate attention, captured by the Baidu search volume index, in the downside risk. Using 45 keywords from five perspectives related to climate change, we construct a public climate attention index in China. We find a positive and significant relationship between climate attention and downside risk at the market‐level and firm‐level. Moreover, the risk‐increase effect of climate attention becomes more prominent for state‐owned and high‐carbon‐emission firms. Further analysis shows that excellent sustainable performance can moderate the adverse effect of rising climate attention, while the major climate disasters exacerbate the effect. Overall, our findings shed additional light on the important role of collective climate beliefs in corporate risk management and investor decision‐making.
Boom, bust, action! How communities can cope with boom‐bust cycles in unconventional oil and gas development
Authors: Arnold Gwen , Klasic Meghan , Schomburg Madline , York Abigail , Baum Melissa , Cherin Maia , Cliff Sydney , Kavousi Parisa , Miller Alexandria Tillett , Shajari Diana , Wang Yuer , Zialcita Luigi 
Published: June 2022

AbstractScholarship on boom‐busts cycles in resource extraction often assumes that affected resource‐rich communities are at best reactive, at worst helpless, in the face of the large, exogenous shocks this cycle visits upon them. Researchers infrequently examine what communities themselves can do to improve their economic prospects and residents' quality of life amidst booms and busts. In this review paper, we identify and synthesize work scattered across disparate academic and gray literature—in planning, law, community economic development, rural sociology, economics, and political science, among others—to holistically assess what we know about how communities can use local policymaking to manage impacts of booms and busts associated with unconventional oil and gas drilling (UOGD), often called “fracking.” We highlight examples of communities tackling this task using vertical and horizontal governance strategies and distill expert recommendations for how communities can build boom‐bust resiliency generally and in key areas impacted by UOGD.
Investment in visual system predicted by floral associations in sap beetles (Coleoptera: Nitidulidae)
Authors: Powell Gareth S. , Bybee Seth M. 
Published: June 2022

AbstractPatterns in morphological variation are a central theme of evolution. Uncovering links between morphological character evolution and natural history, specifically feeding behaviour, is important to understanding biological diversity. Species within the sap beetles (Nitidulidae) exhibit a tremendous diversity of feeding behaviours. This immense diversity of feeding can be seen both between major lineages and very closely related taxa. Feeding behaviour diversity may drive morphological variation in several character systems (e.g., eyes). For example, in a shift from feeding on rotting fruit to flower‐visiting (anthophily), selective pressures on the visual system may vary and ultimately lead to differences in eye morphology. We tested for potential morphological shifts in relative eye size among adult beetles. We specifically tested for significant relationships between relative eye size and the following factors flower‐visiting and sex. We also tested for the influence of phylogeny on the evolution of relative eye size, implementing tests of trait correlation across a topology. We found greater relative eye size in taxa exhibiting anthophilous behaviour, regardless of phylogenetic relatedness or feeding behaviour of sister taxa. We were unable to recover a relationship between relative eye size and sex. Thus, feeding behaviour is currently the strongest predictor of eye size in sap beetles.
Current state of antimicrobial stewardship and organ transplantation in Saudi Arabia
Authors: Almaziad Sultan , Bosaeed Mohammad 
Published: June 2022

BackgroundAntimicrobial resistance constitutes a major public health issue that leads to poor outcomes and increased costs associated with healthcare. Solid organ transplant recipients are more prone due to prolonged exposure to antimicrobials.MethodsWe reviewed existing programs in the Kingdom of Saudi Arabia and pattern of drug resistance, and the extent of transplant medicine in the kingdom through published articles in databases and official documents from health authorities.ResultsA national committee for antimicrobial resistance (AMR) was established to set the guidelines required for an antimicrobial stewardship program (ASP), especially when there is a high prevalence of AMR. A survey noted that ASPs are implemented in only 26% of Saudi Ministry of Health hospitals. Factors affecting the implementation of ASPs in Saudi hospitals included a lack of necessary staff resources and specific ASP staff/teams to advocate adopting ASP in the organizations. Specific attention should be given to transplant patients as transplantations are expected to increase in the next few years. No antimicrobial stewardship programs are currently specifically tailored to transplant centers.ConclusionThe current healthcare system transformation in Saudi Arabia should take into consideration the urgent need for effective ASP that might help face the increasing trends in the multidrug‐resistant organisms (MDRO) prevalence rate.
Nationwide estimates of the need for prehospital blood products after injury
Authors: Hashmi Zain G. , Jansen Jan O. , Kerby Jeffrey D. , Holcomb John B. 
Published: June 2022

AbstractIntroductionPrehospital blood product resuscitation after injury significantly decreases risk of mortality. However, the number of patients who may potentially benefit from this life‐saving intervention is currently unknown. The primary objective of this study was to estimate the number of patients who may potentially benefit from prehospital blood product resuscitation after injury in the United States. The secondary objective was to estimate the amount of blood products needed for prehospital resuscitation of injured patients.MethodsPatients ≥16 years with blunt/penetrating injuries included in National Emergency Medical Services Information System 2019 were identified and classified into four separate cohorts of hemodynamic instability: Cohort 1 (systolic blood pressure [SBP] <90 mmHg), Cohort 2 (SBP <90 and/or heart rate [HR] >120), Cohort 3 (SBP <90 and HR >108 or SBP <70), and Cohort 4 (shock index ≥1). The need for prehospital blood was estimated by multiplying number of patients in each cohort with average number of blood products used for prehospital resuscitation.ResultsAfter exclusions, 3.7 million adult trauma patients were included. The number of patients who may potentially benefit from prehospital blood products was estimated as 89,391 (Cohort 1), 901,346 (Cohort 2), 54,160 (Cohort 3), and 300,475 (Cohort 4). Assuming 1 unit of whole blood is needed per patient, a lower‐bound estimate of 54,160 additional whole blood units (0.6% of current collections) will be need for prehospital resuscitation of the injured.ConclusionsAnnually, between 54,000 and 900,000 patients may potentially benefit from prehospital blood product resuscitation after injury in the United States. Prehospital blood utilization and collection of blood products will need to be increased to scale‐up this life‐saving intervention nationwide.
A Subatomic Proof System for Decision Trees
Authors: Barrett Chris , Guglielmi Alessio 
Published: June 2022

We design a proof system for propositional classical logic that integrates two languages for Boolean functions: standard conjunction-disjunction-negation and binary decision trees. We give two reasons to do so. The first is proof-theoretical naturalness: The system consists of all and only the inference rules generated by the single, simple, linear scheme of the recently introduced subatomic logic. Thanks to this regularity, cuts are eliminated via a natural construction. The second reason is that the system generates efficient proofs. Indeed, we show that a certain class of tautologies due to Statman, which cannot have better than exponential cut-free proofs in the sequent calculus, have polynomial cut-free proofs in our system. We achieve this by using the same construction that we use for cut elimination. In summary, by expanding the language of propositional logic, we make its proof theory more regular and generate more proofs, some of which are very efficient.
That design is made possible by considering atoms as superpositions of their truth values, which are connected by self-dual, non-commutative connectives. A proof can then be projected via each atom into two proofs, one for each truth value, without a need for cuts. Those projections are semantically natural and are at the heart of the constructions in this article. To accommodate self-dual non-commutativity, we compose proofs in deep inference.
Cerebral Blood Flow Velocity Modulation and Clinical Efficacy of Acupuncture for Posterior Circulation Infarction Vertigo: A Systematic Review and Meta-Analysis
Authors: Li Boxuan , Zhao Qi , Du Yuzheng , Li Xiayu , Li Zefang , Meng Xianggang , Li Chen , Meng Zhihong , Chen Junjie , Liu Chaoda , Cao Beidi , Chi Shihao 
Published: June 2022

Background. Vertigo is a cardinal symptom of posterior circulation infarction (POCI). Acupuncture is demonstrated to have a beneficial effect on posterior circulation infarction vertigo (PCIV). However, the mechanism of acupuncture therapy is not clarified. This study aims to assess the cerebral blood flow velocity modulation and clinical efficacy of acupuncture for PCIV patients. Methods. We conducted this systematic review for clinical randomized controlled trials (RCTs) regarding acupuncture on PCIV. The study duration was from September 2020 to September 2021. We searched the PubMed, EMBASE, Cochrane Library, Web of Science, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Database, and VIP. The publication date was set from inception to August 31, 2020. Based on the inclusion and exclusion criteria, two researchers independently screened literature and extracted data including basic study information, intervention details, outcome details, and adverse events. Outcome measures included the blood flow velocities of vertebrobasilar arteries and the Clinical Effective Rate of posterior circulation infarction vertigo. Pooled data were presented as standardized mean differences (SMDs) and relative risks (RR), with 95% confidence intervals (CIs). The meta-analysis was conducted using Review Manager software version 5.3.0. Results. A total of 20 eligible RCTs (1541 participants) were included in this review, which compared acupuncture therapy (1 RCT) or acupuncture combined with pharmaceutical therapy (19 RCTs) to pharmaceutical therapy in patients with posterior circulation infarction vertigo. 7 studies assessed the blood flow velocities of the basilar artery examined by Transcranial Doppler (TCD), 8 studies assessed the bilateral vertebral arteries, and 13 studies evaluated the Clinical Effective Rate of posterior circulation infarction vertigo. Meta-analysis results showed that blood flow velocities of the basilar artery (SMD = 0.58, 95% CI = 0.40–0.76;

P
<
0.05

), left vertebral artery (SMD = 0.48, 95% CI = 0.22–0.73;

P
<
0.05

), and right vertebral artery (SMD = 0.44, 95% CI = 0.19–0.69;

P
<
0.05

) were significantly higher in the acupuncture group compared with the control group. Clinical Effective Rate (RR = 1.22, 95% CI = 1.15–1.29;

P

=

0.792

) was significantly better in the acupuncture group compared with the control group. Conclusions. This study shows that acupuncture therapy is useful in improving the blood flow velocity of vertebrobasilar arteries and Clinical Effective Rate in patients with posterior circulation infarction vertigo. However, double-blind, sham-controlled trials with large sample sizes are required to support our conclusions.
A TCR-like CAR Promotes Sensitive Antigen Recognition and Controlled T-cell Expansion Upon mRNA Vaccination
Authors: Birtel Matthias , Voss Ralf-Holger , Reinhard Katharina , Rengstl Benjamin , Ouchan Yasmina , Michel Kristina , Hayduk Nina , Tillmann Bodo , Becker René , Suchan Martin , Theobald Matthias , Oehm Petra , Türeci Özlem , Sahin Ugur 
Published: June 2022

Chimeric antigen receptor (CAR) T cells are efficacious in patients with B-cell malignancies, while their activity is limited in patients with solid tumors. We developed a novel heterodimeric TCR-like CAR (TCAR) designed to achieve optimal chain pairing and integration into the T-cell CD3 signaling complex. The TCAR mediated high antigen sensitivity and potent antigen-specific T-cell effector functions in short-term in vitro assays. Both persistence and functionality of TCAR T cells were augmented by provision of costimulatory signals, which improved proliferation in vitro and in vivo. Combination with a nanoparticulate RNA vaccine, developed for in vivo expansion of CAR T cells, promoted tightly controlled expansion, survival, and antitumor efficacy of TCAR T cells in vivo.Significance:A novel TCAR is tightly controlled by RNA vaccine–mediated costimulation and may provide an alternative to second-generation CARs for the treatment of solid tumors.