bluuebunny/crossref_metadata_2025_split huggingface dataset:
N-terminal Pro-B-Type Natriuretic Peptide is a Myocardial Biomarker in Pulmonary Sepsis and Septic Shock
Authors: Tyurin I. N. , Protsenko D. N. , Kozlov I. A. 
Published: October 2022

The objective: to study changes and prognostic significance of the blood NT-proBNP in the patients with pulmonary sepsis.Subjects and Methods. The study included 34 patients aged 54.5 ± 2.9 years with pulmonary sepsis or septic shock. Lethality in the intensive care unit (ICU) was 47.1%. NT-proBNP, procalcitonin (PCT) levels, blood lactate and hemodynamic parameters were registered on the 1st day (stage 1) and on the 4th-5th day of the ICU stay (stage 2). Hemodynamics was assessed through transpulmonary thermodilution. The differences were considered statistically significant at p < 0.05.Results: At stage 1, NT-proBNP level was 5,220 [1,380‒17,850] pg/ml, did not decrease (p = 0.726) at stage 2 and amounted to 1,760 [631‒847] pg/ml. At stage 1, NT-proBNP correlated with extravascular lung water index (rho = 0.445; p = 0.038) and systolic pulmonary artery pressure (rho = 0.414; p = 0.023). At stage 2, NT-proBNP correlated with PCT (rho = 0.569; p = 0.003), blood lactate (rho = 0.525; p = 0.001), and mean arterial pressure to norepinephrine dosage ratio (rho = -0.422; p = 0.035). At stage 1, NT-proBNP was no predictor of lethality in the ICU: OR 1.0000; 95% CI 1.0000-1.0001. At stage 2, NT-proBNP > 4,260 pg/ml (sensitivity 87.5%, specificity 94.4%) was a predictor of lethality: OR 1.0004, 95% CI 1.0000-1.0008, p = 0.046 (AUC 0.893, 95% CI 0.732-0.974). Any increase of NT-proBNP level (> 0 pg/ml) between stages 2 and 1 was a predictor of lethality (sensitivity 87.5%, specificity 94.4%): OR 119.0, 95% CI 9.7432‒1,453.4241, p = 0.0002 (AUC 0.903, 95% CI 0.751-0.977).Conclusion: Patients with pulmonary sepsis are characterized by a significant increase of blood NT-proBNP. At stage 1, the biomarker correlated with pulmonary hypertension and moderate pulmonary edema and was no predictor of lethality. At stage 2, NT-proBNP correlated with the indices of infection and sepsis severity (procalcitonin, blood lactate, and mean arterial blood pressure/norepinephrine dosage ratio). At this stage, NT-proBNP levels greater than 4,000 pg/mL and/or any degree of increase in blood levels of the biomarker were both sensitive and specific predictors of a lethal outcome. Specific features of etiopathogenesis of BNP hyperproduction in pulmonary sepsis make it difficult to interpret the elevation of NT-proBNP as an indicator of septic cardiomyopathy but does not reduce its value as a sensitive and specific predictor of lethality.
Effect of Dexamethasone and Lidocaine on the Cytokine Profile and Bleeding during Endoscopic Rhinosinus Surgery
Authors: Pavlov V. E. , Pervakova M. Yu. , Kuznetsova D. A. , Blinova T. V. , Surkova E. A. , Lapin S. V. , Polushin Yu. S. 
Published: October 2022

The objective: to evaluate the feasibility of using dexamethasone and lidocaine to potentiate the effect of anesthesia in patients with chronic polypous rhinosinusitis during functional endoscopic sinus surgery (FESS) interventions.Subjects and Methods. Clinical data, blood serum samples were collected prospectively from 52 patients who underwent FESS intervention. The patients were divided into 3 groups: Control Group ‒ C (n = 26), anti-inflammatory drugs were not administered; Dexamethasone Group ‒ D (n = 13), dexamethasone was administered (0.10‒0.15 mg/kg); and Lidocaine Group ‒ L (n = 13), a 1% solution of lidocaine was administered intravenously. The following parameters were studied: IL-6, IL-10, IL-18, alpha1-antitrypsin, and ferritin.Results. An increase of IL-6, IL-6/IL-10 was observed in Group C. An increase of IL-10 and a decrease of IL-6, IL-6/IL-10 were noted in Group D. In Group L, IL-6, IL-6/IL-10 did not change significantly. The intensity of bleeding was lower in Groups L (p < 0.001) and D (p < 0.05) versus Group C. Relative changes in the concentration of biomarkers within the normal range were detected in all groups.Conclusions. Changes in the cytokine profile are insignificant in patients with chronic polyposis rhinosinusitis during FESS performed under combined anesthesia.No convincing data on the need for intraoperative use of dexamethasone or intravenous lidocaine have been received.
Drug Therapy of Cognitive Dysfunction in Minimally Invasive Surgery during Anesthesia with Sevoflurane
Authors: Neymark M. I. , Shmelev V. V. , Rakhmonov A. A. , Nazarchuk E. A. 
Published: October 2022

The objective: To conduct a comparative assessment of efficacy of Cytoflavin and Cellex for management of cognitive disorders after videolaparoscopic cholecystectomy performed under general inhalation anesthesia with sevoflurane.Results. In three representative groups (n = 30) of patients, markers of inflammation (CRP and IL-6), levels of brain-specific proteins (S-100 and NSE) were studied. Neuropsychological testing were performed by using the MoCA test, frontal dysfunction test battery (FAB) by two stages (stage I ‒ on the eve of the operation, stage II ‒ on the 7th day of the postoperative period). In patients of Group I (n = 30), disorders of higher mental functions of the early postoperative period persisted, which served as the basis for finding ways to eliminate and manage the identified disorders. For this purpose, Cytoflavin was used in Group II (n = 30), and Cellex was used in Group III (n = 30).Comparative characteristics of the level of brain-specific proteins revealed a statistically significant decrease at stage I in Groups II and III versus Group I. The lowest level of both NSE (by 1.45 μg/l, p = 0.041) and S-100 (by 10.1 ng/l, p = 0.044) was observed in Group III versus Group II. In addition, at the second stage of the study, the greatest severity of the inflammatory response was noted in Groups II and III of patients compared to Group I and this degree of severity could be potentiated by the ongoing drug therapy. If in Group I, disorders of higher mental functions persisted on the 7th day of the postoperative period, then as a result of the ongoing drug therapy in Groups II and III, it was possible to achieve significantly better results of neuropsychological testing.Conclusion. Administration of drug therapy contributed to the improvement of higher mental function eliminating cognitive deficit in the early postoperative period.
Information Value of Calculated Hematological Indices in the Assessment of Cardiac Risk in Oncological Surgery
Authors: Sokolov D. A. , Kozlov I. A. 
Published: October 2022

The objective: to study information value of the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in the cardiac risk assessment in abdominal oncological surgery.Subjects and Methods. 94 patients of 68 [62‒73] years old who underwent elective surgery were examined.Results. Cardiovascular comortbidity was diagnosed in 69 (73.4%) patients. 11 (11.7%) perioperative cardiovascular complications were registered. Cardiac mortality was 4.3%. Hematological indices were not associated with cardiovascular diseases (NLR: OR = 0.59‒1.42; 95% CI 0.14‒2.60; p = 0.29‒0.74, PLR: OR = 0.99‒1.00; 95% CI 0.97‒1.01; p = 0.31‒0.99). NLR and PLR were not predictors of cardiovascular complications (OR = 0.67; 95% CI 0.19‒2.37; p = 0.46 and OR = 1.00; 95% CI 0.99‒1.01; p = 0.68) and cardiac death (OR = 0.21; 95% CI 0.01‒8.05; p = 0.23 and OR = 0.99; 95% CI 0.98‒1.01; p = 0.79).Conclusion. NLR and PLR cannot be recommended for the cardiac risk assessment in abdominal oncological surgery.
Some Aspects of Pituitary-Adrenal and Autonomic Nervous Systems Functioning in Patients with Chronic Consciousness Disorders
Authors: Rybakov G. Yu. , Kondratyeva E. A. , Tsentsiper L. M. , Denisova A. A. , Dryagina N. V. , Lesteva N. A. , Ivanova A. O. , Kondratyev A. N. 
Published: October 2022

Patients with chronic disorders of consciousness (CDoC) have various variants of the pathological organization of functions including sympathetic hyperactivity and hormonal changes.The objective: to determine the severity of paroxysmal sympathetic hyperactivity (PSH), the function of the pituitary-adrenal system in patients with CDoC.Subjects and Methods. 54 patients with CDoC were enrolled in the study. Patients were randomized in the groups depending on assessment on the Coma Recovery Scale-Revised scale and CRS-R index calculation. PSH severity was assessed 7 times a day for two days. During the first week from the moment of admission, blood sampling was performed 7 times a day to study the levels of ACTH and cortisol.Results. PSH syndrome was detected in all groups, there were no significant dependencies of its severity on the time of day. There were no significant differences in the levels of ACTH and cortisol during the day.Conclusions: PSH syndrome is observed in most patients with CDoC. In patients with CDoC, the daily rhythm of ACTH and cortisol secretion are disrupted.
Inflammatory Response in Patients with Spontaneous Intracranial Hemorrhages
Authors: Tsentsiper L. M. , Dryagina N. V. , Terekhov I. S. , Aybazova M. I. , Rumyantseva M. V. , Petrov A. E. , Petrova A. O. , Kondratyev A. N. 
Published: October 2022

Mortality and disability rates in spontaneous intracranial hemorrhages remain high despite medical advances. In recent decades, much attention has been paid to neuroinflammation as a typical response to brain damage. Inflammation plays an important role in the acute and chronic phases of the disease. The relationship between plasma and cerebrospinal fluid cytokines, as well as the factors affecting their ratios, is currently not completely clear.The objective was to study the inflammatory response to spontaneous intracranial hemorrhage.Subjects and Methods. 59 patients aged 18 to 72 years (48 ± 6) were enrolled in the study. Patients were admitted to the intensive care unit after an episode of spontaneous intracranial hemorrhage. The levels of interleukins in blood plasma were studied: 6, 8, 10, TNF-α, C-reactive protein,blood leukocytes, and procalcitonin (by a semi-quantitative method). In the cerebrospinal fluid, the following parameters were evaluated: cytosis, protein, glucose, lactate, cytokines (6, 8, 10, TNF-α). Blood samples were collected on days 1, 2, 3, 5, 7, 9, 14, 21, 28, 35, and 45.Results. Systemic inflammatory response developed in all patients from the first day of acute brain injury. The most significant response was formed by glial brain cells which was confirmed by high levels of cytokines in the cerebrospinal fluid, hundreds and thousands of times higher than blood levels of cytokines.Conclusion. Levels of pro-inflammatory cytokines are predictors of an unfavorable outcome.
Assessment of Severity and Prediction of Outcomes in Premature Newborns Based on the nSOFA Scale
Authors: Mironov P. I. , Lekmanov А. U. , Amirova V. R. , Idrisova R. G. 
Published: October 2022

The objective: to evaluate the applicability of the nSOFA scale as a predictor of an unfavorable outcome in premature newborns.Subjects. The study was designed as retrospective and observational. The study enrolled 109 newborns with a gestational age of ≤ 32 weeks of pregnancy (birth weight 1,071 (772‒1,451) g, gestational age 29 (26‒32) weeks, 22 (20,4%) patients died. nSOFA scores were determined based on the first 72 hours after birth, and a peak values were used for analysis. Death was considered an unfavorable outcome.Results. The nSOFA score > 3 was associated with a odds ratio = 2.5 (CI 1.39–4.64, p = 0.002) for an unfavorable outcome. The area under the ROC curve was 0.796 (95% CI = 0.763–0.827).Conclusion. The nSOFA scale is an acceptable tool for measuring the severity of organ dysfunction and predicting mortality in premature newborns, regardless of the etiology of the disease.
State of knowledge and future research needs on microplastics in groundwater
Authors: Belkhiri Amélie Hoarau , Carre Florence , Quiot Fabrice 
Published: October 2022

Abstract
Microplastics (MPs) are widespread in aquatic and soil environments. This study targets the issue of MPs’ transfer from soil to groundwater. Scientific papers were collected and analyzed using a text-mining approach that classifies text segments. This allowed the identification of four research topics and the organization of the results into a summarizing table. Those four topics are sources of groundwater MPs, main types of MPs (physico-chemical properties, polymer units, shapes, and size), human exposure (mainly drinking water), and potential environmental and human effects. Compared to the research of MP on aquatic or soil compartments, scientific data on MP in groundwater are less substantial. Current results show a divergence due to differences in context (alluvial aquifer, fractured rock aquifer, karst aquifer, etc), collecting, sampling, and analytical methods. This divergence requires further research with standardized analytic protocols and reference materials. The associated research gaps were identified by using the same approach. The following five topics emerged: (1) the transfer of MPs from soil to underground, (2) the contribution of groundwater to drinking water microplastic pollution, (3) the interaction with other contaminants, (4) the human and environmental effects, and (5) the protective and remediation solutions.
Risk perception from the consumption of untreated drinking water in a small island community
Authors: Nik Hassan Nik Muhammad Nizam , Hunter Paul R. , Lake Iain R. 
Published: October 2022

Abstract
A small island community in Malaysia uses gravity-fed drinking water, and rejected water treatment by the authorities. This study was conducted to evaluate the community's risk perception towards their untreated water supply by interviewing one adult per household in four out of eight villages on the island. The survey asked questions on risk perception, socioeconomic characteristics, and perception of water supply quality. Water samples were collected from a total of 24 sampling locations across the four villages, and 91.7% of them were positive for E.coli. The study surveyed 218 households and found that 61.5% of respondents agreed to some degree that the water is safe to drink without treatment, while 67.9% of respondents disagreed to some degree that drinking tap water is associated with health risks, and 73.3% of respondents agreed to some degree that it is safe to drink directly from taps that are fitted with water filters. Using factor analysis to group the risk perception questions and multivariable GLM to explore relationships with underlying factors, the study found that older respondents, lower income level, positive water odour perception and positive water supply reliability perception lowers risk perception. The village of residence also significantly affects the risk perception level in the model.
Recent Applications of Bioinformatics in Target Identification and Drug
Discovery for Alzheimer’s Disease
Authors: Singh Sushil Kumar , Kumar Ashok , Singh Ravi Bhushan , Ghosh Powsali , Bajad Nilesh Gajanan 
Published: October 2022

Abstract:
Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disease characterized by progressive memory loss. The main pathological features of the disease are extracellular deposition of amyloid β (Aβ) plaques and intracellular neurofibrillary tangles composed of hyper-phosphorylated tau protein. The understanding of factors contributing to AD progression, number of molecular signatures, and the development of therapeutic agents played a significant role in the discovery of disease-modifying drugs to treat the disease. Bioinformatics has established its significance in many areas of biology. The role of bioinformatics, in drug discovery is emerging significantly and will continue to evolve. In recent years, different bioinformatics methodologies, viz. protein signaling pathway, molecular signature differences between different classes drugs, interacting profiles of drugs and their potential therapeutic mechanisms have been applied to identify potential therapeutic targets of AD. Bioinformatics tools were also found to contribute in the discovery of novel drugs, omics-based biomarkers, and drug repurposing for AD. The review aims to explore the applications of various advanced bioinformatics tools in the identification of targets, biomarkers, pathways, and potential therapeutics for the treatment of the disease.
Going beyond common motivational strategies and teaching styles
Authors: Riandi Riandi 
Published: October 2022

This paper aims to determine the styles of teaching and motivational strategies carried out by two teachers in Frank McCourt’s Teacher man (McCourt, 2005) and School of Rock, a film (Linklater, 2003). The comparative method is used in this study as an effort to take a scientific approach on literary works. The researcher sorted, dissected, and compared literary works in different settings to make meaning, to convey their feelings, sentiments, and concepts to the author himself as a reader. Based on the findings, teachers in Frank McCourt’s Teacher man (McCourt, 2005) and School of Rock, a film (Linklater, 2003) make their students interested in the material being discussed in class they are more likely to channel their own internal motivation towards education and end up learning more. Teaching beyond the curriculum standards should be viewed as incredible opportunity to create meaningful lessons that will capture the attention of all students. Keywords: motivational strategies, teaching styles, teaching
TATA RIAS DALAM TOKOH TARI SIMO GRINGSING
Authors: Mahyanto Aditiya Rizki 
Published: October 2022

Ki Ageng Gringsing merupakan tokoh ulama islam yang menyebarkan agama islam di pulau jawa khususnya di kabupaten Batang. Kesaktian Ki Ageng Gringsing yaitu beliau dapat menjelma menjadi ular simo, dan istrinya Nyi Ageng Gringsing dapat menjelma menjadi ular. Tari Simo Gringsing adalah bentuk tari tunggal, namun dalam penyajiannyajumlah penari tidak dapat di batasi. Tarian ini dapat disajikan dalam berbagai tokoh seperti, simo, peperangan antar kelompok, begal garong dengan macan, atau bisa juga dengan tokoh ki Ageng Gringsing.Dalam penampilannya Tari Simo Gringsing di iringi dengan gamelan, rebana, jidor, terompet serta tata rias busana agar sajian lebih menarik.
Petanque: Apakah Direct Instruction dapat meningkatkan kemampuan shooting dan pointing atlet?
Authors: Putra Miftah FP , Kurdi Kurdi 
Published: October 2022

Penelitian ini memiliki tujuan untuk mengetahui apakah penggunaan model direct instruction dapat meningkatkan kemampuan shooting dan pointing atlet petanque Papua. Untuk mencapai tujuan tersebut jenis penelitian tindakan (action research) akan digunakan dengan subjek penelitian adalah atlet petanque Papua yang diambil dengan teknik sampling total (n = 22). Terdapat tiga instrumen yang digunakan, yaitu tes (pointing dan shooting), lembar observasi, serta dokumentasi. Teknik analisis data yang digunakan adalah deskriptif dan uji t sampel berpasangan (dependent sample t test). Hasil penelitian menemukan penggunaan model direct instruction dapat meningkatkan kemampuan shooting dan pointing pada atlet petanque Papua. Selain itu, penerapan model DI juga disenangi oleh para atlet karena memadukan secara langsung angtara teori dengan praktik. Petanque: Is Direct Instruction can improve the shooting and pointing abilities of athletes? AbstractThis research aimed to determine whether the use of direct instruction models can improve the shooting and pointing abilities of Papuan petanque athletes. The action research will be used with the subject of the study being the Papuan petanque athletes taken by total sampling technique (n = 22). There are three instruments used, namely tests (pointing and shooting), observation sheets, and documentation. The data analysis technique used is descriptive and dependent sample t-test. The results of the study found that the use of direct instruction models can improve shooting and pointing abilities in Papuan petanque athletes. Besides, the application of the DI model is also loved by athletes because it integrates directly between theory and practice.
Hambatan dan tantangan proses pelestarian budaya lokal dalam konteks seni tradisi pencak silat di tasikmalaya
Authors: Muslihin Heri Yusuf , Pranata Oyon Haki , Nurlaela Wulan , Cahyana Cahyana 
Published: October 2022

Fakta-fakta di lapangan mengenai hambatan dan tantangan selama proses pelestarian budaya lokal. Seni tradisi pencak silat merupakan pendekatan proses yang diduga dapat memberikan stimulasi positif terhadap aspek perkembangan budaya lokal di Tasikmalaya. Penelitian ini dilakukan untuk mengetahui kontribusi seni tradisi pencak silat terhadap pengembangan budaya lokal. Penelitian ini menggunakan metode deskriptif kualitatif dengan survey design. Teknik pengumpulan data menggunakan observasi terstruktur, wawancara, catatan lapangan dan dokumentasi. Hasil yang didapatkan untuk paguron aliran seni tradisi pencak silat yaitu 40 paguron. Hambatannya adalah wawasan dan tingkat pengetahuan paguron serta SDM yang relatif terbatas pada adat kebiasaan yang diturunkan dari pendahulunya, sedangkan yang menjadi tantangan banyaknya jumlah paguron yang berbasis seni tradisi pencak silat, tetapi belum berkontribusi optimal dalam mengembangkan pelestarian budaya lokal serta prestasi pencak silat Tasikmalaya. PROCESS OF PRESERVING LOCAL CULTURE IN THE CONTEXT OF TRADITIONAL ART PENCAK SILAT IN TASIKMALAYA: BARRIERS AND CHALLENGES AbstractFacts on the ground regarding barriers and challenges during the process of preserving local culture. The traditional art of pencak silat is a process approach that is thought to provide positive stimulation to aspects of the development of local culture in Tasikmalaya. This research was conducted to determine the contribution of the traditional art of pencak silat to the development of local culture. This study uses a qualitative descriptive method with a survey design. Data collection techniques used structured observation, interviews, field notes and documentation. The results obtained for the paguron of the traditional art of pencak silat are 40 pagurons. The barriers is the insight and level of knowledge of the paguron as well as the relatively limited human resources on the customs handed down from its predecessors, while the challenge is the large number of pagurons based on the traditional art of pencak silat, but have not contributed optimally in developing the preservation of local culture and the achievements of Tasikmalaya pencak silat.