bluuebunny/crossref_metadata_2025_split huggingface dataset:
Um projeto de pesquisa de ensino de matemática pensado para o aluno deficiente visual do Instituto Federal do Paraná - IFPR
Authors: Langwinski Luani Griggio , Somavilla Adriana Stefanello , Pimentel Leonardo Silguero 
Published: October 2022

Neste artigo, pretende-se divulgar o projeto de pesquisa intitulado Ensino de matemática para o deficiente visual, que está sendo desenvolvido no Instituto Federal do Paraná – IFPR – Campus Foz do Iguaçu, que tem como objetivo elaborar materiais didáticos, apresentando estratégias e recursos instrucionais que promovam o ensino e aprendizagem dos conceitos de matemática para estudantes com deficiência visual. O projeto é constituído por acadêmicas do curso de Licenciatura em Física, o aluno deficiente visual do curso Técnico em Informática e integrantes do Grupo de Pesquisa em Educação, Ciências e Matemática (GPECiM)/IFPR. O projeto que iniciou neste ano de 2019, contribui para a aproximação da relação professor/aluno, na formação dos professores para lidar com determinadas deficiências buscando estratégias didáticas e amparando o aluno com deficiência visual nas suas dificuldades e dúvidas em relação aos conteúdos de matemática.
Qualidade de vida de professores do ensino superior: avaliação de professores da área de Engenharia de Produção no Brasil
Authors: Pinto Guilherme Moreira Caetano , Pedroso Bruno , Moraes Jessyca , Picinin Claudia Tania 
Published: October 2022

OBJETIVO: Analisar a produção científica dos docentes que atuam em programas de pós-graduação na área de Engenharia de Produção no Brasil de 2013 a 2015. MÉTODOS: Para tal, o instrumento WHOQOL-bref foi aplicado através da plataforma Google Drive em 130 professores que atuam in programas de pós-graduação de Engenharia de Produção.RESULTADOS: Os resultados mostraram maior deficiência de Qualidade de Vida nas facetas Recreação e Lazer (53,08), Sentimentos Positivos (57,88) e Sono e Repouso (29,42). Os pontos de maior satisfação foram quanto a Mobilidade (83,85), Autoestima (81,73) e Ambiente do lar (80,58). Além disso, os domínios Psicológico (70,48) e Físico (70,27) foram os melhores escores. Por outro lado, Ambiente (66,18) e Relações Sociais (66,28) apresentaram as piores pontuações. Conclui-se que a carreira docente justifica alguns aspectos positivos e negativos da Qualidade de Vida da população pesquisada.CONCLUSÕES: Verificou-se que os homens pontuaram mais alto que as mulheres, enquanto os professores com bolsa de pesquisa tiveram pontuações mais altas de qualidade de vida em comparação com os que não tinham bolsa de pesquisa. Além disso, foi possível identificar que indivíduos com 16 anos ou mais de tempo de serviço apresentaram os menores escores em quatro dos sete itens e que indivíduos com tempo de serviço entre oito a 15 anos apresentaram os maiores escores em seis dos sete itens avaliados neste estudo.
Avaliação de impacto do projeto esporte cidadão da cidade de Indaiatuba/SP sobre o estado nutricional e a qualidade de vida de seus participantes
Authors: Giron Jemima , Cyrillo Denise Cavallini 
Published: October 2022

OBJETIVO: Avaliar o impacto do Projeto Esporte Cidadão (PEC) sobre o estado nutricional e a qualidade de vida de seus participantes. MÉTODOS: Estudo longitudinal (2018-2019), com dois grupos, Grupo Caso e Grupo Controle, e duas variáveis de desfecho, estado nutricional (medidas antropométricas) e qualidade de vida (Escala Multidimensional de Satisfação com a Vida Infantil). Para a avaliação foi utilizado o método econométrico de diferenças em diferenças.RESULTADOS: Foram avaliadas 30 crianças no Grupo Caso (média de 9,6 anos, DP±1,10 anos, sendo 53,33% meninos) e 41 crianças do Grupo Controle (média 8,9 anos, DP±0,77 anos, sendo 36,34% meninos). A estimação dos modelos mostrou que a participação no PEC não impactou nem no estado nutricional nem na qualidade de vida das crianças participantes, apenas o tamanho da família mostrou influência positiva estatisticamente significante sobre o estado nutricional e a idade da criança sobre a qualidade de vida mostrou uma relação negativa.CONCLUSÕES: Os resultados contrapõem os achados que apontam correlação estaticamente significativa entre atividade física, estado nutricional e qualidade de vida. Não foi possível constatar impacto do PEC sobre o estado nutricional e a qualidade de vida. Um fator que pode explicar a ausência de impacto positivo está relacionado à frequência efetiva de crianças no projeto, aspecto que não foi possível controlar.
Uma metodologia de análise de estratégias para a gestão da experiência do cliente a partir da criação do relacionamento superior
Authors: Custódio Juliana Cândido 
Published: October 2022

Com a mudança do cenário de negócios e comportamento de consumo, faz-se necessária a investigação de como as empresas podem criar sistemas eficazes para gerenciar estratégias e manter a sua vantagem competitiva. Por isso, o objetivo deste estudo é propor uma escala multidimensional para a avaliação das estratégias voltada à gestão da Experiência do Cliente, apresentando uma nova perspectiva, embasada na teoria da criação de capacidades dinâmicas e na criação do relacionamento superior entre a empresa e seus stakeholders. O estudo constitui-se de análises qualitativas e quantitativas, realizadas por meio de observação, entrevistas e aplicação de questionários. Uma perspectiva sistemática para criar e avaliar estratégias é apresentada, permitindo o alinhamento das ações para o atingir objetivos, melhorar a gestão de processos e de relacionamento internos e externos na criação de experiência memoráveis de compra.
Characterization of Errors in Retinopathy of Prematurity Diagnosis by Ophthalmologists-in-Training in the United States and Canada
Authors: Al-Khaled Tala , Patel Samir N. , Valikodath Nita G. , Jonas Karyn E. , Ostmo Susan , Allozi Rawan , Hallak Joelle , Campbell J. Peter , Chiang Michael F. , Chan R.V. Paul 
Published: October 2022

Purpose:
To identify the prominent factors that lead to misdiagnosis of retinopathy of prematurity (ROP) by ophthalmologists-in-training in the United States and Canada.

Methods:
This prospective cohort study included 32 ophthalmologists-in-training at six ophthalmology training programs in the United States and Canada. Twenty web-based cases of ROP using wide-field retinal images were presented, and ophthalmologists-in-training were asked to diagnose plus disease, zone, stage, and category for each eye. Responses were compared to a consensus reference standard diagnosis for accuracy, which was established by combining the clinical diagnosis and the image-based diagnosis by multiple experts. The types of diagnostic errors that occurred were analyzed with descriptive and chi-squared analysis. Main outcome measures were frequency of types (category, zone, stage, plus disease) of diagnostic errors; association of errors in zone, stage, and plus disease diagnosis with incorrectly identified category; and performance of ophthalmologists-in-training across postgraduate years.

Results:

Category of ROP was misdiagnosed at a rate of 48%. Errors in classification of plus disease were most commonly associated with misdiagnosis of treatment-requiring (plus error rate = 16% when treatment-requiring was correctly diagnosed vs 81% when underdiagnosed as type 2 or pre-plus; mean difference: 64.3; 95% CI: 51.9 to 76.7;
P
< .001) and type 2 or pre-plus (plus error rate = 35% when type 2 or pre-plus was correctly diagnosed vs 76% when overdiagnosed as treatment-requiring; mean difference: 41.0; 95% CI: 28.4 to 53.5;
P
< .001) disease. The diagnostic error rate of postgraduate year (PGY)-2 trainees was significantly higher than PGY-3 trainees (PGY-2 category error rate = 61% vs PGY-3 = 35%; mean difference, 25.4; 95% CI: 17.7 to 33.0;
P
< .001).

Conclusions:
Ophthalmologists-in-training in the United States and Canada misdiagnosed ROP nearly half of the time, with incorrect identification of plus disease as a leading cause. Integration of structured learning for ROP in residency education may improve diagnostic competency.

[
J Pediatr Ophthalmol Strabismus
. 2023;60(5):337–343.]
Transcriptomic Profiling Identifies CD8+ T Cells in the Brain of Aged and Alzheimer’s Disease Transgenic Mice as Tissue-Resident Memory T Cells
Authors: Altendorfer Barbara , Unger Michael Stefan , Poupardin Rodolphe , Hoog Anna , Asslaber Daniela , Gratz Iris Karina , Mrowetz Heike , Benedetti Ariane , de Sousa Diana Marisa Bessa , Greil Richard , Egle Alexander , Gate David , Wyss-Coray Tony , Aigner Ludwig 
Published: October 2022

Abstract
Peripheral immune cell infiltration into the brain is a prominent feature in aging and various neurodegenerative diseases such as Alzheimer’s disease (AD). As AD progresses, CD8+ T cells infiltrate into the brain parenchyma, where they tightly associate with neurons and microglia. The functional properties of CD8+ T cells in the brain are largely unknown. To gain further insights into the putative functions of CD8+ T cells in the brain, we explored and compared the transcriptomic profile of CD8+ T cells isolated from the brain and blood of transgenic AD (APPswe/PSEN1dE9, line 85 [APP-PS1]) and age-matched wild-type (WT) mice. Brain CD8+ T cells of APP-PS1 and WT animals had similar transcriptomic profiles and substantially differed from blood circulating CD8+ T cells. The gene signature of brain CD8+ T cells identified them as tissue-resident memory (Trm) T cells. Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis on the significantly upregulated genes revealed overrepresentation of biological processes involved in IFN-β signaling and the response to viral infections. Furthermore, brain CD8+ T cells of APP-PS1 and aged WT mice showed similar differentially regulated genes as brain Trm CD8+ T cells in mouse models with acute virus infection, chronic parasite infection, and tumor growth. In conclusion, our profiling of brain CD8+ T cells suggests that in AD, these cells exhibit similar adaptive immune responses as in other inflammatory diseases of the CNS, potentially opening the door for immunotherapy in AD.
Tumor Environment Promotes Lnc57Rik-Mediated Suppressive Function of Myeloid-Derived Suppressor Cells
Authors: Wang Ya , Gao Yunhuan , Zhang Chunze , Yue Jianmei , Wang Rong , Liu Hang , Yang Xiaorong , Zhang Yuan , Yang Rongcun 
Published: October 2022

Abstract
Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes with potent immunosuppressive activity that regulate immune responses in the tumor microenvironment. We identified a novel long noncoding RNA (lncRNA), named as lnc57Rik, in the MDSCs that controls their immunosuppressive functions. Lnc57Rik was induced in in vitro and in vivo inflammatory settings and upregulated the genes related to MDSC-mediated immunosuppression, including Arg-1, NOS2, NOX2, and COX2. Furthermore, Lnc57Rik can not only bind with the C/EBPβ isoform liver-enriched activator protein to activate C/EBPβ but also with the methyltransferase WD repeat-containing protein 5 that enables the enrichment of histone H3 trimethylated lysine 4 marks on the promoter regions of Arg-1, NOS2, NOX2, and COX2, eventually resulting in their transcriptional activation. Furthermore, the conserved human lnc57Rik has a similar function as murine lnc57Rik. Taken together, upregulation of lnc57Rik in the tumor microenvironment promotes the immunosuppressive function of MDSCs.
Acceptability of the Kangaroo Mother Care at the University Hospital of Treichville in Côte d’Ivoire
Authors: Doukouré Daouda , Kourouma Kadidiatou Raissa , Yacé Marie Laurette Agbré , Cissé Lassina , Méazieu Chantière Some , Manouan Mathilde N'Guetta , Lasme Ester Annick , Bayo Syntyche , Aké-Tano Sassor Odile Purifine , Kouakou Julie Sackou , Kouakou Virginie Konan 
Published: October 2022

Background. Kangaroo Mother Care (KMC) is a low-tech, high-impact intervention for preterm and low-birth-weight newborns. In 2019, Côte d’Ivoire opened its first KMC unit. We wanted to determine KMC’s acceptability in Côte d’Ivoire after a year.Methods. This qualitative study used semi-structured interviews in September 2020 at the Teaching Hospital of Treichville’s first KMC unit. Mothers of preterm and low birth weight babies who received KMC were studied. Deductive (TFA-driven) framework analysis was performed. Coded using Nvivo 12.Results. KMC was acceptable overall. Mothers knew KMC’s goal and benefits, including self-confidence and breastfeeding benefits. Most women reported that the method was easy to implement and were confident in implementing KMC at the unit or in the household, even though some of them found KMC not aligned with their cultural values. Some mothers, especially housewives and self-employed, highlighted the benefits of KMC, but they must have given up.Conclusions. Our study highlighted the need to increase KMC awareness, advocacy, education, and training for pregnant women and the community to reduce preterm and low birth weight infant mortality and morbidity.
Caraway extract alleviates atopic dermatitis by regulating oxidative stress, suppressing Th2 cells, and upregulating Th1 cells in mice
Authors: Khajepour Fardin , Zangouyee Mohammad Reza , Khosravimashizi Arezu , Afgar Ali , Abdollahi Vahideh , Dabiri Shahriar , Nosratabadi Reza 
Published: October 2022

Objective:
To explore the anti-inflammatory and antioxidant effects of caraway on atopic dermatitis (AD) in mice.

Methods:
AD was induced in two stages, including sensitization and challenge with the application of 2,4 dinitrochlorobenzene 2% and 0.2%, respectively. Clinical symptoms and histological analysis of the skin were assessed. The effects of caraway on oxidant/antioxidant parameters as well as Th1- and Th2-related cytokines were also evaluated.

Results:
Caraway reduced the severity of dermatitis in AD-induced mice, as evidenced by significant inhibition of Th2-related cytokines (IL-4 and IL-13) and increased Th1-related cytokine (IFN-γ). Additionally, treatment with caraway significantly increased superoxide dismutase and catalase activity and decreased the malondialdehyde level in the serum of AD mice. Furthermore, caraway inhibited the differentiation of Th2 cells while favoring Th1 cell differentiation in the spleen via regulating their master transcription factors GATA3 and T-bet.

Conclusions:
Caraway could improve AD autoimmune responses and could be considered a potential candidate to treat AD disease.
In vitro anti-melanoma effect of polyphenolic compounds
Authors: Sioud Fairouz , Maatouk Mouna , Bzeouich Imen Mokdad , Ghedira Leila Chekir , Kilani-Jaziri Soumaya 
Published: October 2022

Objective:
To evaluate the effects of phenolic acids (caffeic, ferulic, and coumaric acids) and flavones (luteolin and apigenin) on the proliferation and melanogenesis in murine melanoma B16-F10 cells.

Methods:
Cell proliferation was determined after 24 and 48 hours of incubation using MTT assay. The effects of these tested compounds on cell cycle progression were analyzed by flow cytometry. Moreover, the melanin content and tyrosinase activity were measured spectrophotometrically at 475 nm.

Results:
Luteolin and apigenin exhibited significant anti-proliferative activity against B16-F10 cells, while caffeic, ferulic, and coumaric acids induced slight inhibition after 24 and 48 hours of incubation. The tested compounds disturbed cell cycle progression of B16-F10, by a subsequent decrease in G1 and arrested cycle progression in either G1/S or G2/M phase. Furthermore, apigenin provoked an increase in melanin content of B16-F10 cells. In contrast, luteolin, caffeic, ferulic and coumaric acids induced a decrease in melanin content of B16-F10 cells by inhibiting tyrosinase activity.

Conclusions:
These active polyphenols may be used as skin whitening agents or natural tanning agents to treat skin pigmentation disorders.
Percolation probability and critical exponents for site percolation on the UIPT
Authors: Ménard Laurent 
Published: October 2022

AbstractWe derive three critical exponents for Bernoulli site percolation on the uniform infinite planar triangulation (UIPT). First, we compute explicitly the probability that the root cluster is infinite. As a consequence, we show that the off-critical exponent for site percolation on the UIPT is
$\beta = 1/2$
. Then we establish an integral formula for the generating function of the number of vertices in the root cluster. We use this formula to prove that, at criticality, the probability that the root cluster has at least n vertices decays like
$n^{-1/7}$
. Finally, we also derive an expression for the law of the perimeter of the root cluster and use it to establish that, at criticality, the probability that the perimeter of the root cluster is equal to n decays like
$n^{-4/3}$
. Among these three exponents, only the last one was previously known. Our main tools are the so-called gasket decomposition of percolation clusters, generic properties of random Boltzmann maps, and analytic combinatorics.
Perancangan Sistem Informasi Manajemen Laboratorium Otomasi Berbasis Web Dengan Metode Prototype
Authors: Widharma IG Suputra , Sukarata PG , Sajayasa IM , Sangka ING , Sunaya IN 
Published: October 2022

Laboratorium memiliki peranan yang sangat penting dalam membantu keberhasilan kegiatan perkuliahan perguruan tinggi. Namun demikian masih banyak laboratorium yang belum berfungsi optimal, hal ini dapat terjadi karena sistem pengelolaan laboratorium yang kompleks membutuhkan waktu, anggaran dan sumber daya manusia. Perkembangan teknologi informasi membuat segala aktivitas manusia menggunakan internet. Penelitian ini merupakan penelitian pengembangan dengan metode prototype, yang meliputi tahap analisis kebutuhan, pembuatan desain, pengembangan produk, penerapan produk dan evaluasi produk. Analisis data mengunakan pendekatan kuantitatif melalui pemberian kuesioner kepada kepala lab, teknisi, dosen dan mahasiswa. Hasil penelitian yang diperoleh berupa produk sistem informasi manajemen laboratorium secara online (silab) berupa website meliputi manajemen menu utama dan profil manajemen, panduan praktikum, inventaris alat/bahan, lab virtual, dan jadwal praktikum. Hasil penilaian rata-rata terhadap silab dari stakeholder adalah baik dalam kisaran 80-90.
Aligning Supply Chain through Inventory Ownership Analysis and Performance of Manufacturing Firms in Kenya
Authors: Kimwaki Benedict , Ngugi Patrick , Odhiambo Rommanus 
Published: October 2022

Purpose: The purpose of this study was to establish the influence of roe played by alignment of supply chain through inventory ownership analysis on the performance of manufacturing firms in Kenya.
Methodology: Descriptive and cross-sectional research designs were adopted in this study. The population of the large sized registered members as per the directory is 461. This study employed Cochran’s formula to sample 160 large manufacturing firms from the total population. A structured questionnaire was used to collect data, which was analysed both qualitatively and quantitatively. This study adopted a descriptive data analysis and inferential data analysis. The analyzed data was presented using tables, graphs and pie charts.
Results: The findings of the study revealed that the relationship between inventory ownership analysis and performance was significant at 5% level of significance. The findings of the study revealed that majority of the firms had not effectively posited inventory ownership analysis through, embracing the analysis of acquisition related costs, maintenance related costs, majority had no analysis of salvage related costs. The p-value was 0.000 which indicated that the null hypothesis failed to be accepted at 5% level of significance hence inventory ownership analysis have a significant influence on performance of manufacturing firms in Kenya. The study concluded that through adoption of inventory ownership analysis, the operational costs were reduced as well as the reduction of lead time.
Unique contribution to theory, practice and policy: While the existing transaction cost theory used in this study was validated, the study recommends that the policy makers and management of manufacturing firms should invest in acquisition related costs, maintenance related costs, salvage related costs since it influences performance positively. The policy makers hold a major role in determining how key sectors such as the manufacturing sector are run. The regulators and the legislators formulate policies and guidelines that guide on how manufacturing firms should carry out their operations including supply chain processes. The study also recommended that manufacturing firms policy makers should develop a policy and regulatory framework to accelerate effective implementation inventory ownership analysis to enhance their organizational performance.
PHÁT TRIỂN KINH TẾ TỪ CÁC MÔ HÌNH NÔNG LÂM NGHIỆP Ở HUYỆN ĐOAN HÙNG, TỈNH PHÚ THỌ
Authors: Nguyễn Bình Liêm 
Published: October 2022

Kết quả nghiên cứu cho thấy tại huyện Đoan Hùng, tỉnh Phú Thọ có 4 mô hình nông lâm nghiệp: Vườn - Ao - Chuồng, Vườn - Chuồng - Rừng, Rừng - Vườn - Ao - Chuồng và Vườn - Rừng. Tổng thu nhập trung bình hàng năm của mô hình Vườn - Ao - Chuồng là 188,00 triệu đồng/năm; tương tự của mô hình Vườn - Chuồng - Rừng là 123,50 triệu đồng/năm; Rừng - Vườn - Ao - Chuồng là 100,75 triệu đồng/năm và mô hình Vườn - rừng là 117,25 triệu đồng/năm.
Hầu hết các mô hình phát triển theo nguyên tắc cải tạo mô hình truyền thống bằng chuyển đổi cơ cấu cây trồng, vật nuôi ứng dụng khoa học công nghệ trong trồng trọt, chăn nuôi đạt giá trị kinh tế và môi trường cao, nâng cao hiệu quả sử dụng đất, cải thiện và nâng cao đời sống của người dân. Một số đã trở thành mô hình sản xuất trên đất dốc cần được nhân rộng và đưa ra được sáu giải pháp phát triển các mô hình nông lâm nghiệp bền vững. Huyện đã xây dựng một số mô hình sản xuất có năng suất cao, chất lượng tốt, hướng nông nghiệp sạch, ứng dụng công nghệ cao và đạt hiệu quả rõ rệt.
NGHIÊN CỨU TỐI ƯU HÓA QUY TRÌNH CHIẾT XUẤT CAO LỎNG TỪ CÂY CHÙM NGÂY, CHÓ ĐẺ RĂNG CƯA, CÀ GAI LEO
Authors: Hoàng Thái Hoa Cương 
Published: October 2022

Trong nghiên cứu này chúng tôi tiến hành tối ưu hóa một số điều kiện ảnh hưởng đến quá trình chiết xuất là phương pháp chiết xuất, nồng độ dung môi, tỷ lệ nguyên liệu/dung môi, thời gian chiết xuất, số lần chiết, nhiệt độ ảnh hưởng đến quá trình chiết xuất cao lỏng từ cây chùm ngây, chó đẻ răng cưa, cà gai leo bằng cách thiết kế các thí nghiệm và tính toán hiệu suất chiết xuất. Kết quả cho thấy các thông số tối ưu của quy trình đã được xác định bao gồm. Phương pháp chiết xuất: Chiết hồi lưu, nồng độ dung môi (Ethanol 70%), tỷ lệ dược liệu/dung môi (12/1), số lần chiết (3 lần), thời gian (1,5 giờ), nhiệt độ (70oC).