bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new biomarker for lung metastasis in non-seminomatous testicular cancer: De Ritis Ratio
Authors: Bozkurt Muammer , Aghalarov Samir , Atci Muhammed Mustafa , Selvi Oguzhan , Canat Halil Lutfi 
Published: October 2022

Abstract
Purpose We aimed to show that the De Ritis Ratio (DRR) may be a new biomarker for lung metastasis in non-seminomatous Testicular Cancers (TC).
Material and Methods Patients who underwent radical orchiectomy due to TC between January 2010 and January 2021 were included in the study. Demographic characteristics, preoperative laboratory and radiological findings and pathological data of the patients were recorded. The DRR was calculated from preoperative peripheral blood analysis.
Results A total of 124 patients with non-seminomatous TC were included. Mean patient age was 30.67±7.45 years, and the mean tumour diameter was 4.69±2.55 cm. 61 patients had T1, 51 had T2, and 12 had T3 disease. 42 of them had lung metastasis; 82 of them had no lung metastasis. The optimal DRR threshold was 1.21 for lung metastasis. [Area Under the Curve (AUC): 0.724 with a sensitivity of 81% and specificity of 74%]. DRR was determined as an independent prognostic factor for lung metastasis in univariate and multivariate analyses (p=0.002).
Conclusions A high preoperative DRR can be used to detect the presence of lung metastases in non-seminomatous TCs.
Acrotrione B, a Prenylated and Highly Oxidized Xanthenoid with Antibacterial and Anti-proliferative Activities from the Roots of Acronychia pedunculata
Authors: Wisetsai Awat , Lekphrom Ratsami , Suebrasri Thanapat , Tontapha Sarawut , Senawong Thanaset , Pudhom Khanitha , Choodej Siwattra , Schevenels Florian T. 
Published: October 2022

AbstractA new prenylated xanthenoid with a highly oxidized core, acrotrione B (1), together with six previously reported acetophenones (2 – 7), were isolated from the roots of
Acronychia pedunculata. The structures of the isolated compounds were elucidated by thorough analysis of their 1D and 2D NMR spectroscopic data. The relative and absolute
configurations of acrotrione B were determined by electronic circular dichroism (ECD) calculations. Acrotrione B is an unusual, oxidized xanthenoid with a cyclohexadienone core that has not
been previously reported. It thus represents a new skeletal type within the xanthenoid class. Acrotrione B (1) exhibited anti-proliferative activity against Hela
(IC50 = 16.0 µM) and A549 (IC50 = 16.3 µM) cell lines. 5′-Prenylacrovestone (4) and acrovestone (5) were even more potent with IC50 values of
5.1 µM and 0.77 µM, respectively, against Hela cells and 11.8 µM and 1.13 µM, respectively, against A549 cells. Moreover, acrotrione B (1) displayed moderate antibacterial activities
against Staphylococcus aureus, Bacillus cereus, and Bacillus subtilis, with MIC values in the range of 16 – 64 µg/mL. Finally, acropyrone (6) showed a significant
suppression of lipopolysaccharide (LPS) induced NO production in murine macrophage J774.A1 cells (IC50 = 8.9 µM).
Comparison of Intraocular Tamponade in Patients with Peripheral Tear-Induced Retinal Detachment and Coexisting Macular Hole without High Myopia
Authors: Ozturk Yücel , Ağın Abdullah , Yucel Gencoglu Aysun , Talan Mustafa , Bulut Muhammed Nurullah 
Published: October 2022

Abstract
Introduction To introduce the surgical results and examine the effect of intraocular tamponades on surgical outcomes in patients with coexisting macular hole (MH) and rhegmatogenous retinal detachment (RRD) without high myopia.
Methods This retrospective, cross-sectional, two-center study was carried out with 29 eyes of 29 patients. The patients were divided into two groups according to the intraocular tamponade used in surgery: silicone oil (Group 1) and C3F8 gas (Group 2). In all patients, the internal limiting membrane was peeled during surgery. Exclusion criteria were determined as RRD with MH due to high myopia (≥ 6 D) without peripheral retinal tears and traumatic MH.
Results In Group 1, the median preoperative best-corrected visual acuity (BCVA) was 3.0 (M ± SD: 2.85 ± 0.27) logMAR, while the median postoperative BCVA was 1.0 (M ± SD: 1.39 ± 0.83) logMAR (p < 0.001). In Group 2, the median preoperative BCVA was 3.0 (M ± SD: 2.37 ± 0.93) logMAR, while the median postoperative BCVA was 0.76 (M ± SD: 1.06 ± 0.86) logMAR (p = 0.008). The retinal attachment success rate was 15/17 (89.3%) in Group 1, and 11/12 (91.7%) in Group 2 (p = 0.64). The MH closure rate was 12/17 (71.6%) in Group 1, and 10/12 (78.1%) in Group 2 (p = 0.52). No difference was determined between the groups in terms of preoperative and postoperative BCVA, preoperative and postoperative intraocular pressure, and BCVA improvement.
Conclusions The study results showed no significant difference between using silicone oil or C3F8 gas as an intraocular tamponade after internal limiting membrane peeling in patients with RRD due to peripheral tear with coexisting MH.
Use of Vasopressin as Rescue Therapy in Refractory Hypoxia and Refractory Systemic Hypotension in Term Neonates with Severe Persistent Pulmonary Hypertension—A Prospective Observational Study
Authors: Shah Sachin , Dhalait Saleha , Fursule Anurag , Khandare Jayant , Kaul Amita 
Published: October 2022

Objective Persistent pulmonary hypertension of the newborn (PPHN) is a serious cardiorespiratory problem. PPHN is frequently associated with refractory hypoxia and hypotension, and optimal management has the potential to improve important clinical outcomes including mortality. The primary objective is to evaluate the efficacy and safety of rescue vasopressin (VP) therapy in the management of severe (refractory) hypoxia and refractory systemic hypotension in term neonates with severe PPHN.
Study Design Neonates with refractory hypoxia and refractory hypotension due to severe PPHN needing VP were prospectively enrolled in the study. Refractory hypoxia was defined as oxygenation index (OI) ≥ 25 for at least 4 hours after the commencement of high-frequency oscillatory ventilation and nitric oxide at 20 ppm. Refractory hypotension was defined as mean blood pressure lesser than mean gestational age lasting for more than 15 minutes in spite of dopamine infusion at 10 µg/kg/min, adrenaline infusion at 0.3 µg/kg/min, and noradrenaline infusion at 0.1 µg/kg/min.
Results Thirty-two neonates with PPHN were recruited. The baseline OI (mean ± standard deviation [SD]) before starting VP was 33.43 ± 16.54 which started decreasing significantly between 1 and 6 hours after the commencement of VP (p < 0.05). The mean blood pressure also increased concomitantly with a significant effect seen by 1 hour (p < 0.05). The vasoactive infusion score before the commencement of VP was mean 46.07 (SD = 25.72) and started decreasing after 12 to 24 hours of commencement of VP (p < 0.05). Lactate levels (mean ± SD) before starting VP were 7.8 ± 8.6 mmol/L and started decreasing between 6 and 12 hours (p < 0.05). Two neonates died due to refractory hypoxia and refractory hypotension (overall mortality 6.2%)
Conclusion Rescue VP therapy is a useful adjunct in the management of neonates with severe PPHN with refractory hypoxia and/or refractory hypotension. Improvement in oxygenation and hemodynamics with the use of VP results in reduced mortality.
Key Points
Neonatal and Obstetric Provider Perceptions and Management at 22 Weeks' Gestation
Authors: Nair Shah Nitya , Krishna Iris , Vyas-Read Shilpa , Patel Ravi Mangal 
Published: October 2022

Objective Active treatment for periviable infants may be influenced by neonatal and obstetric provider perceptions of prognosis. The two aims of this study are to (1) quantify prognostic discordance between provider and data-driven survival estimates and (2) evaluate if prognostic discordance is associated with the threshold probability of survival at which neonatal providers recommend active treatment or obstetric providers recommend antenatal corticosteroids.
Study Design Provider survival estimates and threshold probabilities of survival for active treatment and antenatal steroid use were obtained from a case-based survey for an infant or pregnancy at 22 weeks' gestation that was administered at two Atlanta hospitals. Data-driven survival estimates, including ranges, were acquired through the National Institute of Child Health and Human Development Extremely Preterm Birth Outcomes Tool. Prognostic discordance was calculated as the difference between a provider and data-driven estimates and classified as pessimistic (provider estimate below data-driven estimate range), accurate (within range), or optimistic (above range). The association between prognostic discordance and the threshold probability of survival was evaluated using nonparametric tests.
Results We had 137 neonatal respondents (51% response rate) and 57 obstetric responses (23% response rate). The overall median prognostic discordance was 1.5% (interquartile range: 17, 13) and 52 (27%) of all respondents were pessimistic, 100 (52%) were accurate, and 42 (22%) were optimistic. The survival threshold above which neonatal and obstetric providers recommended active treatment or antenatal corticosteroids was 30% (20–45%) and 10% (0–20%), respectively. Thresholds did not significantly differ among the three prognostic discordance groups (p = 0.45 for neonatal and p = 0.53 for obstetric providers). There was also no significant correlation between the magnitude of prognostic discordance and thresholds.
Conclusion Prognostic discordance exists among both neonatal and obstetric providers. However, this discordance is not associated with the threshold probability of survival at which providers recommend active treatment or antenatal corticosteroids at 22 weeks' gestation.
Key Points
Synthesis and Reactivity of a Stable Prototropic Isomer of 2-Acetyl-3-methylpyrrole
Authors: Harran Patrick G. , Lotuzas Aleksandras , El Khoury Anton , Li Liubo 
Published: October 2022

Abstract4-Isocyanobut-1-ene reacted rapidly with acetyl bromide to afford an unstable imidoyl bromide adduct. Subsequent in situ cyclization under Heck conditions generated a stable prototropic isomer of 2-acetyl-3-methylpyrrole. The reactivity of this molecule toward ­acids, bases, and oxidants was explored, and its conversion into an α-methylidene γ-lactam was demonstrated. In protonated form, the molecule functioned as a reactive dienophile in Diels–Alder reactions.
Subarachnoid Hemorrhage with Negative Initial Digital Subtraction Angiography: Subsequent Detection of Aneurysms and Complication Rates of Repeated Angiography
Authors: Nützel Regina , Brandt Silvio , Rampp Stefan , Leisz Sandra , Simmermacher Sebastian , Prell Julian , Strauss Christian , Scheller Christian 
Published: October 2022

Abstract
Background The data on handling of spontaneous, nontraumatic subarachnoid hemorrhage (SAH) with negative initial digital subtraction angiography (DSA) are still inconclusive. The intention of this study was to evaluate the requirement of repeat DSA in patients with negative initial DSA and to compare the clinical outcomes of these cases.
Methods In a retrospective study, we reviewed patients with SAH and negative initial DSA treated in our department from January 2006 until December 2017. The patients were divided according to an established radiographic classification into perimesencephalic (pm) and nonperimesencephalic (npm) SAH. An interventional neuroradiologist and a neurosurgeon reviewed all DSA scans.
Results In all, 52 patients with negative initial DSA, comprising 36 (69.2%) patients with pm and 16 (30.8%) patients with npm bleeding pattern, were included. All patients underwent a second and 23 of these patients underwent a third DSA. In these 23 patients, subarachnoid blood distribution in the initial computed tomography (CT) scan was suspicious for the presence of aneurysm. In total, two aneurysms were detected during the second DSA (diagnostic yield: 3.85%). Both were in the pm group (diagnostic yield: 5.6%). The second repeat DSA did not show any causative vascular lesion. Complications after the DSA occurred in only 2 of 127 patients (1.6%). The rate of complications concerning vasospasm (pm 52.8%, npm 56.3%), hydrocephalus (pm 47.2%, npm 50%), and the need for temporary or permanent shunt (pm 44.4%, npm 50%) was similar in both groups and there was no statistically significant difference.
Conclusion Repeat DSA after negative initial DSA in pm SAH had a diagnostic yield of 5.6%. However, a second repeat DSA cannot be recommended in case of SAH with initial negative DSA. The pm SAH should not be underrated concerning the occurrence of complications and cared with a high level of surveillance.
Postoperative Intracranial Hypotension-Associated Venous Congestion after Spinal Surgery Managed with Multiple Blood Patches: Case Report
Authors: Kurzbuch Arthur Robert , Bourlond Baudouin , García Martínez Juan José , Bonjour Thierry , Novaes Natalia P. , Tuleasca Constantin , Millán Diego San 
Published: October 2022

Abstract
Background Postoperative intracranial hypotension-associated venous congestion (PIHV) is a rare event. The authors report the case of a patient presenting with PIHV after spinal surgery following the sudden loss of cerebrospinal fluid (CSF) induced by suction drainage.
Methods A 69-year-old patient underwent uneventful revision surgery for wound dehiscence after lumbar surgery with placement of a subfascial suction drain.
Results Postoperatively, the patient presented with fluctuating consciousness and a generalized tonic–clonic seizure. Computed tomography (CT) and serial magnetic resonance imaging (MRI) were performed showing convexity subarachnoid hemorrhages (SAHs), diffuse swelling of the brain and thalami and striatum bilaterally without diffusion restriction, and signs of intracranial hypertension resulting in pseudohypoxic brain swelling in PIHV. A dural leak at L3–L4 was treated with several CT-guided patches combining autologous blood and fibrin glue injections. The patient recovered without neurologic deficit and follow-up MRI revealed progressive complete reversal of brain swelling, and re-expansion of CSF spaces.
Conclusion PIHV is a rare but potentially fatal entity. Awareness of PIHV after cranial or spinal surgery leads to early treatment of CSF hypovolemia and possibly better clinical outcome. Following acute CSF volume loss, an acute elevation of cerebral blood volume overcoming autoregulatory mechanisms seems a likely explanation for diffuse cerebral vasogenic edema and SAH in PIHV.
Cardiac Effects of COVID-19 Infection, MIS-C, and the Vaccine in Infants and Children: What Is Known and Future Implications
Authors: Schwartz Bryanna N. , Harahsheh Ashraf S. , Krishnan Anita , Martin Gerard R. 
Published: October 2022

The cardiac effects of novel coronavirus disease 2019 (COVID-19) infection on the pediatric heart has become an area of particular interest as elevated cardiac enzymes and abnormalities on echocardiogram and electrocardiogram were seen in a portion of children affected by the virus. In this article, we review the cardiac manifestations of acute COVID-19 infection, multisystem inflammatory syndrome in children, and postvaccine myocarditis. The limited research on the effects of COVID-19 on neonates and infants is also reported.
Key Points
First principles calculation to investigate the structural, electronic, elastic, mechanical, and optical properties of K2NiP2 ternary compound
Authors: Mbilo Mwende , Musembi Robinson 
Published: October 2022

First-principles calculations of the structural, electronic, elastic, mechanical, and optical properties of the K2NiP2 ternary compound using density functional theory as implemented in the quantum espresso package have been performed. The calculations have been done using the generalized gradient approximation (GGA) with the Perdew–Burke–Ernzerhof (PBE, PBEsol) exchange-correlation functionals and the local density approximation (LDA). The lattice parameters have been found to agree with the available experimental results. Direct bandgaps have been obtained as 0.630, 0.588, and 0.525 eV when using the GGA-PBE, GGA-PBEsol, and LDA approximations, respectively. In all three scenarios, the valence bands have been noted to be majorly formed by Ni-3d and P-2p states with little contribution from the other states, whereas the conduction bands have been observed to be mainly formed by P-2p states with a small contribution from the other states. The K2NiP2 has been found to be mechanically stable, ductile, and ionic. The optical properties showed that the compound under investigation has a high refractive index and absorption coefficients covering the ultraviolet–visible regions, thus indicating its potential for photovoltaic applications. The bandgaps obtained using LDA were smaller than those obtained using GGA. This is because LDA underestimates the bandgaps.
Features of gate-tunable and photon-field-controlled optoelectronic processes in a molecular junction: Application to a ZnPc-based transistor
Authors: Petrov Elmar G. , Shevchenko Yevgen V. , Gorbach Victor V. , Lyubchik Svetlana , Lyubchik Andriy 
Published: October 2022

Taking into account the fact that the transitions between the states of a molecular junction are carried out against the background of much faster relaxation processes in molecular terms and the conduction bands of electrodes, kinetic equations for integral occupancies of the molecular terms, as well as expressions for the time-dependent electronic current and radiation power of the fluorophore molecule, are obtained. Using the example of a molecular junction based on a ZnPc fluorophore, the transformation of a transient optoelectronic process into a stationary one is demonstrated. Corresponding analytical expressions are derived, including overall rates, which determine the characteristic times of establishing equilibrium current and light emission. The temporary process of the reorganization of the transmission channels dependently on the magnitude and polarity of the gate voltage as well as an external optical field is also demonstrated. The dependence of the overall rates on the elementary rates characterizing the recharge of the molecule, as well as radiation and nonradiative transitions in the molecule, is obtained. Estimates show that in a ZnPc-based transistor, the characteristic transition time is 10–100 ps if the current is in the range of 0.1–10 nA.
Effects of verb and construction frequency in sentence comprehension
Authors: Kim Hyunwoo , Shin Gyu-Ho 
Published: October 2022

Abstract
Two theoretical viewpoints provide different explanations about how people extract statistical regularities from
input to assess the felicity of verb usage in a sentence. The lexical approach emphasizes the role of verb frequency in
determining a verb’s distributional bias within a sentence, whereas the entrenchment hypothesis highlights the conjoined roles of the frequency information from both a verb and an argument structure construction. The present study tests these accounts by
investigating Korean speakers’ interpretation of two dative patterns in Korean (Dative–Accusative and Accusative–Accusative).
Through the analysis of a large-scale corpus, we calculated the frequency of each dative pattern as well as the frequency of
dative verbs occurring therein. Using this information, we conducted an acceptability judgment task with Korean speakers by
manipulating the dative type and the verb frequency. The results showed that the speakers’ acceptability rating behavior was
affected by the interaction between the verb and construction frequency such that highly entrenched verb–construction
combinations were evaluated to be more acceptable. Our finding supports the entrenchment hypothesis that emphasizes the conjoined
roles of usage frequency of verbs and constructions in sentence comprehension.
Gravitational waves induced from primordial black hole fluctuations: the effect of an extended mass function
Authors: Papanikolaou Theodoros 
Published: October 2022

AbstractThe gravitational potential of initially Poisson distributed primordial black holes (PBH) can induce a stochastic gravitational-wave background (SGWB) at second order in cosmological perturbation theory. This SGWB was previously studied in the context of general relativity (GR) and modified gravity setups by assuming a monochromatic PBH mass function. Here we extend the previous analysis in the context of GR by studying the aforementioned SGWB within more physically realistic regimes where PBHs have different masses. In particular, starting from a power-law cosmologically motivated primordial curvature power spectrum with a running spectral index we extract the extended PBH mass function and the associated to it PBH gravitational potential which acts as the source of the scalar induced SGWB. At the end, by taking into account the dynamical evolution of the PBH gravitational potential during the transition from the matter era driven by PBHs to the radiation era we extract the respective GW signal today. Interestingly, in order to trigger an early PBH-dominated era and avoid the GW constraints at BBN we find that the running of the spectral indexαsof our primordial curvature power spectrum should be within the narrow rangeαs⋲ [3.316,3.355] × 10-3while at the same time the GW signal is found to be potentially detectable by LISA.
Half-disk lasers with active region based on InGaAs/GaAs quantum well-dots
Authors: Zubov Fedor I , Moiseev Eduard I , Maximov Mikhail V , Vorobyev Alexandr A , Mozharov Alexey M , Shernyakov Yuri M , Kalyuzhnyy Nikolay A , Mintairov Sergey A , Kulagina Marina M , Dubrovskii Vladimir G , Kryzhanovskaya Natalia V , Zhukov Alexey E 
Published: October 2022

Abstract
Half-disk lasers fabricated by cleaving initial full-disk lasers have an advantage of directional light outcoupling as well as increased output power and efficiency as compared to full-disk lasers of the same diameter. The continuous wave output power of a 200 µm diameter half-disk laser exceeds 70 mW. Quasi single-mode lasing with a high side-mode suppression ratio more than 20 dB is demonstrated for half-disk lasers of various diameters. A maximum 3 dB small signal modulation frequency of 4.9 GHz was measured for a 100 µm in diameter half-disk laser.
Size effect of mortar specimens under uniaxial compression
Authors: Kovac M 
Published: October 2022

Abstract
This paper investigates the phenomenon of the size effect of quasi-brittle lime-based material. This research aims to confirm the existence of a size effect on a homogeneous material - test specimens of mortar, which are subjected to uniaxial compression and provide additional knowledge to explain the causes of the size effect. This paper deals with the analysis of the results of experimental tests of mortar specimens without inclusion and with one centrally located steel inclusion. Two series of tests with different slenderness and size were prepared. The results of the experiment showed that the compressive strength of the test specimens decreased with increasing specimen size. The larger interface area between the inclusion and the mortar matrix negatively affected the compression strength.