bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of rehabilitation sport on breast-cancer related lymphedema and quality of life
Authors: Böer Bettina , Seller Anna , Schönfisch Birgitt , Krainick-Strobel Ute , Dietrich Andreas , Brucker Sara Yvonne , Wallwiener Diethelm , Niess Andreas , Hahn Markus 
Published: April 2022

Abstract
Purpose
Surgery and radiotherapy as part of breast cancer treatment can lead to lymphoedema of the upper extremities (breast cancer-related lymphoedema = BCRL) and reduce the quality of life (health-related quality of life = HRQoL). The aim of the present study was to investigate the influence of paddling in a dragon boat (PP), on HRQoL and BCRL in breast cancer survivors (BCS).
Methods
Between April and October 2017, a prospective case-control study evaluated the effects of PP compared to a control group. In the paddle group (n = 28), weekly arm circumference measurements were taken at four defined anatomic areas of the arm before and after training; in the control group (n = 70) the measurements were taken once a month. At the beginning and end of the study, questionnaires from both groups (SF 36, EORTC QLQ-C30) were evaluated to understand the differences in HRQoL.
Results
The paddle group started with a higher HRQoL compared to in the control group. Most interesting, whether the affected or unaffected arm, whether before or after training - the arm circumference decreased over time in the paddling group. A pre-existing lymphoedema was not negatively influenced by paddling. In the paddle group the physical health was constant over the season, while the physical health of the control group decreased significantly over time.
Conclusion
PP in a dragon boat does not lead to the development or worsening of pre-existing lymphoedema due to breast cancer therapy and seems to have a positive effect on the quality of life.
Paeoniflorin drives immunomodulation of mesenchymal stem cells via regulating Th1/Th2 cytokines in oral lichen planus
Authors: Zhang Zhihui , Zhang Yan , Zhao Zhongfang , Li Pei , Chen Danyang , Wang Wei , Han Ying , Zou Shiqi , Jin Xin , Zhao Jianling , Liu Hongwei , Wang Xiao , Zhu Weili 
Published: April 2022

Abstract
Objective To explore the immunomodulatory role of paeoniflorin in mesenchymal stem cells (MSCs) and the involvement of Th1/Th2 cytokines in oral lichen planus.Methods The proliferation of MSCs with different concentrations of paeoniflorin was detected by Cell Counting Kit-8 (CCK8). MSCs were induced by osteoblast, adipoblast and neuroblast followed by Alizarin red, oil red O, real-time PCR and immunofluorescence assays. The effects of paeoniflorin on the migration ability of MSCs was detected by Transwell assay.Results Paeoniflorin promoted the proliferation, migration and multilineage differentiation of MSCs from OLP lesions (OLP-MSCs). OLP-MSCs pretreated with paeoniflorin inhibited the growth of peripheral blood mononuclear cell through G1 phase cell cycle arrest and S phase decrease. In addition, ELISA showed Th1 cytokines were decreased while Th2 cytokines were increased in T lymphocytes co-cultured OLP-MSCs. Furthermore, paeoniflorin pretreated OLP-MSCs exacerbated the secretory changes of these cytokines. OLP-MSCs prolonged the skin graft survival time and improved the graft rejection score and survival rates. Finally, paeoniflorin pretreated OLP-MSCs also adjusted the Th1/Th2 balance in the serum of allograft skin recipient mice.Conclusions Paeoniflorin enhanced MSC immunomodulation and changed inflammatory microenvironment in T lymphocytes, providing a promising therapeutic target for OLP treatment through enhancing the function of OLP-MSCs.
Dose-Dependent Effects of Green Synthesized Silver Nanoparticles on Rat’s Brain
Authors: Tareq Mai , Khadrawy Yasser A. , Rageh Monira M. , Mohammed Haitham S. 
Published: April 2022

Abstract
Metal nanoparticles, in general, and silver nanoparticles (AgNPs), in particular, have been the focus of numerous studies over the last two decades. Recently, the green synthesis of metal nanoparticles has been favored over chemical synthesis due to its low toxicity and easy preparation. The present study aims to investigate the dose-dependent effects of green synthesized AgNPs on rats’ brains. Thirty-four Wistar male rats were divided into four groups. The first, second, and third groups were administered for 14 days with three different doses (0.5, 5, 10 mg/Kg) of AgNPs, respectively. The fourth group, which served as a control group, was given normal saline for the same period. The effects of the green synthesized AgNPs on the cortical and hippocampal levels of the oxidative stress markers (MDA, NO, and GSH) as well as the activity of acetylcholinesterase (AchE) and the monoamine neurotransmitters (DA, NE, and 5H-T) were investigated. AgNPs showed minimal oxidative stress in the cortex and hippocampus for the administered doses. However, AgNPs showed an inhibitory effect on AchE activity in a dose-dependent manner and a decrease in the 5H-T and NE levels. The green synthesized AgNPs showed an ultrastructural change in the cellular membranes of the neurons. The green synthesis of AgNPs has reduced their cytotoxic oxidative effects due to their capping with biologically compatible and boosting molecules such as flavonoids. However, other neurotoxic effects were observed in a dose-dependent manner.
Anomaly Aware Symmetric Non-negative Matrix Factorization for Short Text Clustering
Authors: Fu Bo , Li Ximing , Guan Yuanyuan , Luo Zhongxuan 
Published: April 2022

Abstract

Short text clustering is a significant yet challenging task, where short texts generated from the Internet are extremely sparse, noisy, and ambiguous. The sparse nature makes traditional clustering methods, e.g., k-means family and topic model-ing, much less effective. Fortunately, recent arts of document distance, e.g., word mover’s distance, and document representation, e.g., BERT, can accurately measure the similarities of short texts, especially their nearest neighbors. Inspired by those arts and observations, we induce short text clusters by directly factorizing the informative affinity matrix of nearest neighbors into the product of the cluster assignment matrix, following the intuition that neighboring short texts tend to be assigned to the same cluster. However, due to the noisy nature of short texts, many of them can be regarded as outliers or near-outliers, resulting in many noisy neighboring similarities within the affinity matrix. To further alleviate this problem, we enhance the affinity matrix factorization by (1) incorporating a sparse noisy matrix to directly capture noisy neighboring similarities, and (2) regularizing the cluster assignment matrix by ℓ 2,1 norm to eliminate hard-to-clustering short texts (called pseudo-outliers), so as to indirectly neglect noisy neighboring similarities corresponding to them. After this factorization for pre-clustering, we train a classifier over the resulting clusters, and adopt it to assign each pseudo-outlier to one cluster finally. We call this novel clustering method as Anomaly Aware Symmetric Non-negative Matrix Factorization Ximing Li et al. (A 2 SNMF). Experimental results on benchmark short text datasets demonstrate that A 2 SNMF performs very competitive with the existing baseline methods.
SCREENING OF MUPIROCIN SUSCEPTIBILITY IN CARRIERS OF MRSA AMONG HEALTHCARE WORKERS
Authors: Fatima Naila , G Jyothi Lakshmi 
Published: April 2022

Abstract
Background: Methicillin resistant Staphylococcus aureus (MRSA) is a rampant cause of healthcare associated infections(HAI),causing wide range of infections in patients and is mainly spread by asymptomatic nasal carriage in Health care workers(HCWs).The treatment is topical mupirocin which is becoming ineffective owing to acquisition of mupirocin resistance.Therefore their detection in HCWs and the associated mupirocin resistance is necessary.
Aim: To find the prevalence of MRSA in nasal swabs taken from HCWs
Methods: A nasal swab was collected from the anterior nares of the consenting HCWs. The swabs were then inoculated on basal media and colonies were identified using standard biochemical methods. All Staphylococcus aureus and Coagulase negative Staphylococcus (CoNS) were subjected to disc diffusion method using Cefoxitin (30µg) discs to detect MRSA and MRCoNS. The resistant isolates were tested with mupirocin discs to detect mupirocin resistance.
Results: Of 100 HCWs,S.aureus was isolated in 46 (46%) ,out of which MRSA were 4 (8.69%). CoNS was isolated in 3 (3%) workers, of whom MRCoNS was found in 1 (33.33%). 1 isolate from MRSA(25%) and no MRCoNS showed mupirocin resistance
Conclusion: Healthcare workers complying with the sanitary guidelines is the single most important factor in preventing HAI. There is a need for stringent HAI control practices as well increasing awareness among HCWs about such practices.
Effects of Chronic Non-Invasive Vagus Nerve Stimulation in an Asplenic Individual with Rheumatoid Arthritis: Report from an n-of-1 Study.
Authors: Gr Pascal J.D. 
Published: April 2022

Abstract
Rheumatoid arthritis (RA) is a challenging autoimmune disease to treat. Non-invasive vagus nerve stimulation (nVNS) represents a new era as an alternative to drug-resistance therapy, providing evidence for the anti-inflammatory neuroimmunomodulation (NIM) effect of vagal stimulation along with restoration of functional balance within the autonomic nervous system. This single case study reports the effects of chronic nVNS on an asplenic patient suffering from RA. The study compared the disease activity (DA), the sympatho-vagal balance (SVB), and the NIM index in a 24-month design. Results only showed significant short-term SBV improvement. No other significant gain was found. This study suggested poor efficacity of nVNS after splenectomy.
P-multipliers of Piled Raft Foundations Subjected to Lateral Loading Using F LAC3D
Authors: Tilahun Mulat Worku , Assefa Siraj Mulugeta 
Published: April 2022

Abstract
This study aims at studying the interactions that exist in Piled raft foundations subjected to lateral load using more rigorous computer-based methods. A numerical method using a finite-difference based software F LAC3D was used. The study was conducted using a large strain mode of analysis. For checking, whether the model developed was in good accuracy, a centrifuge model test was used to validate the study. The interfaces between the soil and the structural elements were modeled by providing the interface deformation and strength properties. The structural elements (piles and rafts) are assumed to act in the linear elastic range and hence, an elastic isotropic constitutive model was used. However, the Mohr-Coulomb elastic perfectly plastic model is used to model the soil materials. P-multipliers of piled rafts for pile spacing of 3D and 5D were computed. The pile spacings were varied in two directions and it was observed that the pile spacing in the direction transverse to the loading direction does not affect pile-pile interactions. Application of vertical load to piled rafts subjected to lateral load decreases the lateral displacement of piles subjected to lateral load significantly.
Survival Analysis of Recurrent Events on Women Breast Cancer: The case of Tikur Anbessa Specialized Hospital, Ethiopia
Authors: Biru Tashome Fenta , Akessa Geremew Muleta , Jabir Yasin Negash , Gurmu Selamawit Endale 
Published: April 2022

Abstract
Background
Breast cancer is the most commonly diagnosed cancers worldwide. It is a cancer that develops from breast tissue and most common invasive cancer in women. Recurrent events data have been increasingly important in clinical studies where individuals experience an event more than once and it is a major clinical indicator, which represents the principal cause of breast cancer-related deaths. The aim of the study was to investigate determinants of the recurrence of breast cancer.
Methods
To reach the aim, 421 women with breast cancer were included in the study based on data taken from medical record card of patients enrolled starting from 1st January 2013 to 30th January 2019. A retrospective study has been applied to obtain data on women breast cancer that recorded in oncology department of Tikur Anbessa specialized Hospital. Unmeasured shared similarities due to the impact of multiple events were modeled using a random effect. Cox-PH model and Shared frailty model were used to identify which factor was significantly affecting the recurrence of breast cancer.
Results
From the total of 997 recurrent events, about 609 (61.1%) of them experienced recurrence of breast cancer. The shared log-normal frailty model was chosen as the best fit for this breast cancer data set based on the value of Likelihood cross validation criterion. From the result of shared log-normal frailty model age, stage of breast cancer, tumor size, histology grade, breast feeding and oral contraceptives were significantly associated with recurrence of women breast cancer.
Conclusion
generally shared log-normal frailty model shows that the stage (II, III, IV), tumor size ((3–5) cm, > 5 cm), histology grade (poorly differentiated) and oral contraceptive were significantly increases the risk of recurrence of breast cancer. While, breast feeding was significantly decreases the risk of recurrence of breast cancer. It is recommended that policy maker, ministry of health and Tikur Anbessa Specialized Hospital are expected to make interventions based on these hazardous groups for recurrence of breast cancer.
Wohnungsabnahmen virtuell trainieren
Authors: Dyrna Jonathan 
Published: April 2022

Immersiven Virtual Reality-Lernumgebungen wird ein hohes mediendidaktisches Potenzial zugesprochen, das in der derzeitigen Bildungspraxis jedoch nicht ansatzweise ausgeschöpft wird. Die Formulierung fundierter Handlungsempfehlungen für Leitungs-, Koordinations- und Lehrpersonen zur nachhaltigen Implementation von Virtual Reality-Lernszenarien in ihren Bildungseinrichtungen und Betrieben wird durch eine unzureichende empirische Ergründung erschwert. Sie betrifft insbesondere Kriterien ihrer didaktischen Konzeption und ihres Einsatzes in der Praxis. Hierfür fehlt es bis dato weitgehend an elaborierten Konzepten. Um dem zu begegnen, wird im vorliegenden Beitrag die Entwicklung eines Lernszenarios beschrieben und reflektiert, das eine immersive virtuelle Trainingswelt nutzt, um Immobilienverwaltende aus- bzw. weiterzubilden. Den Kern seines didaktisch flexiblen Konzepts bildet ein Rollenspiel, das einen situierten, konstruktivistischen und sozialen Lernprozess anregen und dadurch die beruflichen Handlungskompetenzen der Lernenden nachhaltig aufbauen bzw. stärken soll. Seine Entwicklung erfolgt in einem iterativen Gestaltungsprozess, der von einer mehrstufigen Mixed-Methods-Evaluation begleitet wird. Das Lernszenario kann in verschiedenen Formen u. a. in Berufsschulen, Berufsförderungswerken und Betrieben eingesetzt werden. Bisherige Pilotversuche zeigen vielversprechende Ergebnisse, machen aber auch wesentliche Herausforderungen für die weitere Entwicklung deutlich.
Risk factors for health problems in children born weighing less than 1500 g
Authors: Dolotova N. V. , Filkina O. M. , Malyshkina A. I. , Nazarov S. B. , Vorobyova E. A. , Kocherova O. Yu. , Matveeva E. A. 
Published: April 2022

Achievements of perinatal medicine and a higher survival rate of children born with extremely low weight require an improvement in the dynamic observation of this category of children at an early age.Purpose. This study aimed at studying the health status of young children with disabilities caused by diseases of the nervous system, born weighing less than 1500 grams, with an analysis of morbidity, physical development, emotional status, and autonomic regulation.Results and conclusion. A clinical and functional study of 74 children born with a body weight of less than 1500 grams made enabled the authors to identify the peculiarities of their health and physical development in the first year of life, to identify risk factors, and to develop a method for predicting the formation of cerebral palsy by one year of life in these children. Consequently, pediatricians and neurologists will be able to timely carry out preventive measures for children from a high-risk group.
Trigger role of infectious agents in the genesis of sudden infant death
Authors: Medvedeva V. V. 
Published: April 2022

Purpose. To increase the effectiveness of diagnostic predictors for the development of sudden infant death based on the study of the role of infectious agents.Materials and methods. A retrospective analysis of 120 cases of development of children, suddenly deceased, medical charts of pregnant women, histories of childbirth of mothers was carried out, and the morphological features of the suddenly deceased children were studied. The frequency of distribution and types of viruses detected using enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction test (PCR) in the examined children who died suddenly in their first year of life were analyzed. Statistical analysis of the research results was made in the MedStat software.Results. The frequency of detection of various infectious agents among the deceased from sudden infant death is (64.4 ± 4.2) %. Morphohistological study indicated characteristic signs of catarrhal tracheobronchitis (83.0 ± 5.5) %, focal intraepithelial inflammation of the larynx and trachea (48.9 ± 7.3) %, desquamative catarrhal pneumonia (31.9 ± 6.8) %, as well as acute focal bronchitis (27.7 ± 6.5) %.Conclusion. The performed study confirms that in the genesis of sudden infant death, along with a role of social and economic, medical and biological factors, there is an obvious negative effect of infectious agents, with the infectious activator working as the trigger and provoking sudden infant death.
The Lymphatic System In The Brain Clearance Mechanisms - New Therapeutic
Perspectives For Alzheimer's Disease
Authors: Chachaj Angelika , Gąsiorowski Kazimierz , Szuba Andrzej , Sieradzki Adrian , Leszek Jerzy 
Published: April 2022

Abstract:
Alzheimer's disease (AD) is the most common cause of dementia worldwide. Pathologi-cal deposits of neurotoxic proteins within the brain, such as amyloid-ß and hyperphosphorylated tau tangles, are the prominent features in AD. According to recent studies, the newly discovered brain lymphatic system was demonstrated to be crucial in the clearance of metabolic macromolecules from the brain. Meningeal lymphatic vessels located in the dura mater drain the fluid, macromole-cules, and immune cells from cerebrospinal fluid (CSF) and transport them, as lymph, to the deep cervical lymph nodes. The lymphatic system provides the perivascular exchange of CSF with inter-stitial fluid (ISF) and ensures the homeostasis of neuronal interstitial space. In this review, we aim to summarize recent findings on the role of the lymphatic system in AD pathophysiology and dis-cuss possible therapeutic perspectives, targeting the lymphatic clearance mechanisms within the brain.
Adherence to, and Persistence of, Antidepressant Therapy in Patients with
Major Depressive Disorder: Results from a Population-based Study in
Italy
Authors: Di Nicola Marco , Dell’Osso Bernardo , Peduto Ilaria , Cipelli Riccardo , Pugliese Anna Cristina , Signorelli Maria Salvina , Ventriglio Antonio , Martinotti Giovanni 
Published: April 2022

Background:
Major depressive disorders represent a significant burden to society, and it
is recommended that antidepressant therapy should last at least 6 months. In Italy, antidepressant
use in clinical practice was reported to increase by 1.7% in 2020 compared to 2019, but only 40% of
new prescriptions are characterized by a treatment duration longer than 3 months.

Objective:
The study aims to describe adherence and persistence to therapy in a subset of antidepressants
(citalopram, duloxetine, escitalopram, paroxetine, sertraline, venlafaxine) vs. vortioxetine
in Italy during a 2-year period from 2017 to 2019.

Methods:
A retrospective analysis of the longitudinal patient database reporting data from general
practitioners on drug prescriptions in Italy was carried out in a cohort of 8,235 adult patients who
were prescribed antidepressants.

Results:
Overall, 32.4% of the patients adhered to treatment for ≥6 months over a 1-year period.
Vortioxetine had a lower risk of low adherence compared to duloxetine, paroxetine, and venlafaxine
and a higher risk compared to citalopram, escitalopram, and sertraline. 68.7% of patients discontinued
treatment during follow-up. The greatest percentage of patients continuing therapy was seen
with duloxetine, while citalopram was associated with the highest proportion of patients discontinuing
therapy. No significant differences in discontinuation were observed when comparing vortioxetine
to the other antidepressants.

Conclusion:
Adherence results were considerably less than the 6-month recommendation in this real-
world analysis of antidepressant therapies. Also, persistence to therapy was low, with most patients
discontinuing treatment. Thus, there is a need for interventions to help patients adhere to their
planned therapy.
Effect of Non-nutritive Sucking during Heel-stick Procedure in Pain Management of Term Infants in the Neonatal Intensive Care Unit: A Systematic Review and Meta-analysis
Authors: Mutlu Birsen , Akbari Negarin , Nadali Javad 
Published: April 2022

Background:
This study aimed to evaluate the efficacy of non-nutritive sucking for analgesia
in term infants undergoing heel-stick procedures.

Methods:
Randomized controlled trials and non-randomized studies based on the PICO framework
were included in the study. Review articles, commentary, pilot, and non-English articles were excluded.
Databases, such as PubMed/MEDLINE, Embase, Scopus, Web of Science, and Cochrane,
were searched until January 31st, 2021, using the keywords “Pain management”, ‘Non-nutritive
sucking”, and “Heel stick”. All studies were reviewed and retrieved by two authors independently
using a standardized form according to the inclusion criteria, and any disagreements were examined
by a third scholar. Quality assessment was evaluated by using the ROB-2 tool. Data were analyzed
using Stata version 12.0 software, and a random-effects model was used for analysis.

Results:
A total of 5,629 articles were retrieved from all databases, and after the screening, finally,
6 relevant articles were included in the analysis. The tools used to control pain in infants in the articles
included PIPP, NFCS, NIPS, and NPASS. The results showed that the pain scores were significantly
lower in the NNS group compared to the control group (MD, -1.05; 95% CI, -1.53 to -0.57)
and NNS had a significant effect on oxygen saturation (O2 Sat) increasing in newborns compared to
the control group, but no significant reduction in the heart rate (HR) between two groups was
observed.

Conclusion:
NNS effectively provides analgesia in full-term neonates undergoing heel-stick procedures;
however, its effects on the long-term outcomes of infants are unclear. The results showed that
NNS was effective in improving heel-stick pain in infants.