bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variable Range Hopping (VRH) charge transport and Poole-Frenkel type conduction mechanism of polypyrrole synthesized with Chemical Oxidative Polymerization
Authors: Balu Gowtham , v Balasubramani 
Published: March 2022

Abstract
Polypyrrole (PPy) was prepared with various weight loadings of acetic acid (10, 30 and 50 wt.%) over chemical oxidative polymerization. The structural and electrical properties of the prepared samples were characterized by XRD and electrical analysis. The charge transport mechanism of PPy was executed by Keithley (6517B) equipment performed between a voltage of 1 to 10 V by the increment of 1 V. The current over capacitor as a role of the applied voltage was carried out from 303 to 403 K temperature range. The XRD result confirms the amorphous nature of PPy. The charge transport process of PPy was deliberated by Mott’s variable-range hopping (VRH) through the conductivities and they found using various weight loadings of acetic acid. The conductivity (σdc) was found to increase with the temperature increase, which indicates the semiconducting nature and the conductivity value calculated was 10− 9 to 10− 7 S/cm for various weight loadings of acetic acid. The I-V study outcomes the linear behavior and the semiconducting nature of PPy, and the study was completed by the explanation of the Poole-Frenkel type conduction mechanism, ln (J) vs. T plots in PPy samples at high fields. It concludes that the comparison of theoretical field-lowering coefficients βS and βPF and the experimental field-lowering coefficients βS and βPF were correlated and the result confirms the Poole-Frenkel type conduction mechanism in PPy. The activation energy diminishes from 1.22 to 1.07 eV with an increase of acetic acid weight percentage.
Sex Specific Cardiometabolic Risk Markers of Left Ventricular Mass in Physically Active Young Adults: The CHIEF Heart Study
Authors: Tsai Kun-Zhe , Liu Pangyen , Huang Wei-Chun , Lima joao , Lavie Carl J. , Lin Gen-Min 
Published: March 2022

Abstract
Background: Greater physical fitness may lead to greater left ventricular mass (LVM) and reduce the effect of cardiometabolic risk factors on LVM. However, the cardiometabolic biomarkers associations for LVM have not been clarified in physically active young adults. Methods: This study included 2,019 men and 253 women, aged 18-43 years, from the military in Taiwan. All participants underwent anthropometric and blood metabolic markers measurements, and completed a 3000-meter run test for assessing fitness. LVM was calculated on the basis of an echocardiography. Multiple linear regression was used to determine the sex-specific associations between cardiometabolic risk markers and LVM indexed for the body height (g/m2.7). Results: In men, age, systolic blood pressure (SBP), 3000-meter running time, serum triglycerides, serum uric acid and waist circumference (WC) were correlated with LVM index (β =0.073, 0.099, -0.005, 0.005, 0.237 and 0.237, respectively; all p-values <0.05). The correlations were not significant for fasting glucose, total cholesterol and high-density lipoprotein cholesterol (HDL-C). In women, SBP, HDL-C and WC were correlated with LVM index in the univariate analysis (β =0.066, -0.050 and 0.318, respectively; all p-values <0.05), whereas the correlation was merely significant for WC in the multiple linear regression analysis (β =0.197; p-value <0.001). Conclusions: In physically active adults, the associations of cardiometabolic risk markers with LVM might vary by sex. Greater physical fitness associated with greater LVM was noted only in men, while greater WC was the only metabolic risk marker for greater LVM in both men and women.
The computational age-at-death estimation from 3D surface models of the adult pubic symphysis using data mining methods
Authors: Kotěrová Anežka , Štepanovský Michal , Buk Zdeněk , Brůžek Jaroslav , Techataweewan Nawaporn , Velemínská Jana 
Published: March 2022

Abstract
Age-at-death estimation of adult skeletal remains is a key part of biological profile estimation, yet it remains problematic for several reasons. One of them may be the subjective nature of the evaluation of age-related changes, or the fact that the human eye is unable to detect all the relevant surface changes. We have several aims: 1) to validate already existing computer models for age estimation; 2) to propose our own expert system based on computational approaches to eliminate the factor of subjectivity and to use the full potential of surface changes on an articulation area; and 3) to determine what age range the pubic symphysis is useful for age estimation. A sample of 483 3D representations of the pubic symphyseal surfaces from the ossa coxae of adult individuals coming from four European (two from Portugal, one from Switzerland and Greece) and one Asian (Thailand) identified skeletal collections was used. A validation of published algorithms showed very high error in our dataset – the MAE ranged from 16.2 and 25.1 years. Two completely new approaches were proposed in this paper: SASS (Simple Automated Symphyseal Surface-based) and AANNESS (Advanced Automated Neural Network-grounded Extended Symphyseal Surface-based), whose MAE values are 11.7 and 10.6 years, respectively. Lastly, it was demonstrated that our models could estimate the age-at-death using the pubic symphysis over the entire adult age range. The proposed models offer objective age estimates with low estimation error and are able to estimate the age using the pubic symphysis across the entire adult age range.
Novel Lipid Metabolism-Related Gene Signature Associated with Clinical and Immune Features in Lung Adenocarcinoma Patients Experiencing Lymph Node Metastasis
Authors: Lao Shen , Chen Zisheng , Xiong Yaming , He Miao , Zheng Yongmei , Liu Xiaoyan , Zhang Jingna , He Jianxing , Liang Wenhua 
Published: March 2022

Abstract
Background: Accumulating evidence revealed that lipid metabolic reprogramming facilitates lymph node metastasis and cancer progression. This study aimed to perform comprehensive bioinformatic analyses of the lipid metabolism-related impact in lung adenocarcinoma (LUAD) patients experiencing lymph node metastasis (LNM). Methods: Clinicopathological information and RNA-sequence data on LUAD patients were collected from the TCGA and GEO databases. Subsequently, 189 differentially expressed lipid metabolism-related genes (LMRGs) were screened for LUAD patients with and without LNM. Based on the risk scoring system related to prognosis, we further correlated the LMRGs with diverse clinicopathological outcomes, genomic alterations, and immune features, as well as immunotherapeutic responses and drug susceptibility.Results: A three-gene lipid metabolic signature (GPD1L, SPHK1, and ST3GAL4) associated with tumor progression in LUAD with LNM was identified. Analyses revealed that the high-risk group had worse overall survival; an increased proportion of M0 macrophages and degranulating mast cell infiltration; increased non-responders to immunotherapy; and resistance to several common TKI drugs. Interestingly, we also found that high-risk patients had higher tumor mutation burdens and PDL-1 expression, suggesting that this subset of patients may benefit from immunotherapy plus LMRG-targeted therapy. Additionally, the results showed that the high-risk group's differentially expressed genes (DEGs) were enriched in the REACTIVE OXYGEN SPECIES pathway. Conclusions: Our findings may provide new insights into molecular mechanisms and precision therapies of lipid metabolism-related LUAD regional metastasis.
Diagnosing disseminated histoplasmosis in advanced HIV/AIDS disease in Cameroon using a point of care lateral flow assay – a case series
Authors: Kuate Marius Paulin Ngouanom , Abessolo Hermine Abessolo , Denning David W. , Stone Neil R. , Ndip Roland Ndip 
Published: March 2022

Abstract
Background
Histoplasmosis is an AIDS-defining opportunistic infection. Disseminated histoplasmosis (DH) can be fatal without early diagnosis and treatment initiation. We present four cases of disseminated histoplasmosis in advanced HIV/AIDS disease patients diagnosed using Histoplasma lateral flow assay (LFA) in Yaoundé, Cameroon.
Cases presentation
: Four women with HIV but unknown CD4 + T cell count were received at the Hospital presenting with asthenia, weight loss, productive cough and fever (39°C) as common symptoms for at least three weeks. Two of the patients had skin lesions. These included facial papules, macules and umbilicated vesicles scattered over the trunk and limbs. These were diffuse lesions which were purulent, itching and papillomatous lesions with a necrotic center, and one patient had a right forearm ulcer. We performed the Histoplasma antigen tests using the Histoplasma antigen lateral flow assay (LFA) and they were strongly positive in all four patients. Histopathology in skin biopsy allowed identification of the species as Histoplasma capsulatum var capsulatum in one patient. In this same patient, Pseudomonas aeruginosa and Proteus mirabilis were cultured from the forearm ulcer. This patient later commenced antibiotics (Levofloxacin 500 mg) and oral itraconazole (800mg/day) with immediate improvement. Unfortunately, the other three patients could not afford itraconazole, were discharged and lost to follow up.
Conclusion
Early diagnosis and treatment are essential for the management of DH. LFA is a test that can be set up in any setting with limited resource. Access to this can be a major advance in the diagnosis of histoplasmosis in resource limited settings.
Left atrial mechanics and functional capacity in HFpEF pts with paroxysmal atrial fibrillation
Authors: Kodeboina Monika , Katbeh Asim , Penicka Martin , Verstreken Sofie , Vanderheyden Marc 
Published: March 2022

Abstract
Introduction: Patients(pts) with paroxysmal atrial fibrillation are at risk for developing heart failure with preserved ejection fraction(HFpEF) and often have an impaired exercise capacity. Since left atrial (LA) pressure plays a major role in the exercise intolerance, we aimed to characterize the contribution of resting LA mechanical properties, assessed by two-dimensional speckle tracking echocardiography upon exercise capacity. Purpose: To evaluate relationship between LA mechanics, measured by LA strain (LAS) and parameters of exercise capacity in pts with paroxysmal atrial fibrillation. Methods: The study included 54 pts(64 ± 10years, 76 % males) with dyspnea (NYHA³II), paroxysmal atrial fibrillation and preserved LV ejection fraction (≥50%). The likelihood of HFpEF was estimated using H2FPEF score. During sinus rhythm, all patients underwent speckle tracking echocardiography and cardiopulmonary exercise testing (CPET). Peak oxygen uptake(VO2peak) served as measure of functional capacity and ventilation/carbon dioxide output slope(VE/VCO2) as surrogate of ventilation/perfusion mismatch. Results: LA contractile strain(S) and strain rate(SR) showed significant correlation with VO2peak(both p < 0.05). LA reservoir, conduit and contractile LAS, all had significant relationship with VE/VCO2 slope (all p<0.050). Pts with LASR above the median had significantly higher VE/VCO2 (p=0.025) and lower VO2peak(p=0.010). In contrast, no correlations were observed between exercise parameters and LA volumes or any other echocardiographic indices. Conclusions: In HFpEF VO2peak and VE/VCO2 are closely related to LA contractile strain, suggesting that abnormalities in LA mechanics may contribute to the blunted exercise capacity. Therefore, we speculate that these markers can be used as an echocardiographic surrogate of functional capacity in HFpEF pts. Further studies are warranted.
Increased expression of NXNL1 in breast cancer associated with favorable prognostic and high level of immune infiltration.
Authors: Gao Hui , Lv Liqiong 
Published: March 2022

Abstract
Objective: Nucleoredoxin Like 1 (NXNL1) is a protein coding gene. Diseases associated with NXNL1 include Retinitis Pigmentosa. However, the roles of NXNL1 in cancer remain unknown. Methods: The expression of NXNL1 was interpreted by The Cancer Genome Atlas (TCGA) database and Genotype Tissue-Expression (GTEX) database. Analysis of NXNL1 genomic alterations and protein expression in human cancer tissues was analyzed by the cBioPortal database and human multiple organ tissue arrays. The correlations between NXNL1 expression and survival outcomes, clinical features, and immune-associated cell infiltration were analyzed using the TCGA, ESTIMATE algorithm, and TIMER databases. Gene Set Enrichment Analysis (GSEA) was applied to elucidate the biological function of NXNL1 in pan-cancer. We evaluated the influence of NXNL1 on survival of BC patients by survival module. Then, data sets of Breast Cancer were downloaded from TCGA. The correlations between clinical information and NXNL1 expression were analyzed using logistic regression. Clinicopathologic characteristics associated with overall survival in TCGA patients using Cox regression. In addition, we explored the correlation between NXNL1 and cancer immune infiltrates using CIBERSORT and “Correlation” module of GEPIA. Results: The differential analysis showed that the level of NXNL1 mRNA expression was upregulated in 23 tumor types compared with normal tissues, which was consistent with its protein expression in most cancer types. The abnormal expression of NXNL1 could predict the survival outcome of patients with breast cancer (BC). The expression of NXNL1 was related to the infiltration levels of various immune-associated cells in breast cancer by TIMER database mining and ESTIMATE algorithm. wherein NXNL1 expression used as the categorical dependent variable, indicated that increased NXNL1 expression is significantly correlated with ER status, PR status, and HER2 status. Moreover, univariate and multivariate analysis revealed that the up-regulated NXNL1 expression is independent prognostic factors for good prognosis. Specifically, a positive correlation between increased NXNL1 expression and immune infiltrating level of the abundance of B cells, Neutrophils, Mast cells and NK cells was established using CIBERSORT analysis. Furthermore, we confirmed it in “correlation” module of GEPIA. Conclusion: Our results suggest that NXNL1 is a potential molecular biomarker for predicting patient prognosis, and immunoreaction in Breast Cancer.
Unknown Extra-Articular Manifestation of Spondyloarthritis: What
About Retroperitoneal Fibrosis? A Case Based Literature Review
Authors: Boussaid Soumaya , Majdouba Marouene Ben , Rekik Sonia , Jammali Samia , Cheour Elhem , Sahli Hela , Elleuch Mohamed 
Published: March 2022

Introduction:
Retroperitoneal fibrosis (RPF) is a rare disease characterized by fibro-inflammatory tissue proliferation in the retroperitoneum. It results in a chronic inflammatory and fibrosis condition, possibly leading to compression of the retroperitoneal structures, especially to encasement of the ureters and the inferior vena cava. It may have an idiopathic or a secondary origin. Spondyloarthritis (SpA) is one of the rare conditions described among the secondary forms.

Case:
Herein, we report a new case of RPF in a patient with AS. Who presented with acute abdominal pain radiating to the lumbar region and the left testicle. On clinical examination, we found a mild stiffness of the lumbar spine and a decrease in chest expansion. Sacroiliac joint pain was also found. The rest of the physical examination was normal. Laboratory tests showed inflammation with increased C-reactive protein (130 mg/l) and creatinine (112 micromol/l) levels. The computed tomography scan revealed a soft tissue density mass located around the sub-renal aorta. Diagnosis of idiopathic RPF associated with AS was retained. The patient was treated by a daily dosage of 1 mg/kg of oral glucocorticoid with good outcome.

Conclusion:
RPF is a rare condition that can be either idiopathic or secondary. Its association with spondyloarthritis, mainly in its ankylosing spondylitis form, seems to be more than anectodal. Treatment may involve medical therapy and/or surgical management.

Key message:
In the presence of back pain, fatigue, weight loss, and low grade fever in spondyloarthritis patients, physicians should screen for retroperitoneal fibrosis as it could be a possible cause.
Es mujer porque María es mujer
Authors: De Materiales Orales Laboratorio Nacional 
Published: March 2022

Esta grabación forma parte de la investigación realizada por el LANMO a través del proyecto CONACyT Materiales orales de la zona lacustre michoacana: documentación, procesamiento y análisis. Se realizó en la casa de Demetria Antonio Guzmán, habitante de la Isla de Pacanda, ubicada en el municipio y lago de Pátzcuaro.
Datos de la entrevista
Fecha: 06 de septiembre de 2015
Duración: (1:03:09)
Personas presentes: Itzi Palomares, Berenice Granados, Georgina Alanis, Adela Rascón, Yunuén Barbosa, Yotzin Viacobo, Abraham Montañés, Santiago Cortés, Quetzal Mata
Lugar (espacio concreto) en el que se llevó a cabo: Casa de Demetria
Medio de grabación: Sony HXR NX70

Datos del narrador

Nombre: Demetria
Apellidos: Antonio Guzmán
Sexo: Femenino
Año de nacimiento: 1943
Lugar de nacimiento: Isla Pacanda, Mich.
Lengua materna: Purépecha
Otras lenguas: Español
¿Sabe leer y escribir? (especificar): No sabe leer ni escribir
Estado civil: Casada
Transcrito por: Georgina Alanis, Berenice Granados, Bianca Pizano, Adela Rascón
Antonio Analco Sevilla y Alberto Diez Barroso Repizo, coords. Lectores de la naturaleza. Memorias de un hacedor de lluvia. México: Secretaría de Cultura, 2016; 107 pp.
Authors: Viacobo Huitrón Yotzin Nekis 
Published: March 2022

Este estudio, dividido en seis capítulos, abre con las palabras de “la figura del hombre del conocimiento”, Antonio Analco Sevilla, tiempero de San Nicolás de los Ranchos, en Xalitzintla, Puebla, una de las comunidades ubicadas en las inmediaciones del volcán Popocatépetl. Su relato comienza en la infancia, cuando tuvo su primer encuentro y comunicación onírica con el volcán, Gregorio Chino Popocatépetl, y con la volcana, Rosita. Desde ese momento, el sueño fue el medio para aprender el saber ancestral.
En los episodios siguientes, cinco especialistas del Instituto Nacional de Antropología e Historia y de la Escuela Nacional de Antropología e Historia analizan la labor de Antonio como mediador entre las entidades naturales y Xalitzintla, pero también su labor en los pueblos aledaños a don Goyo, donde la siembra necesita la lluvia. Mediante una etnografía del ascenso a “el ombligo” del volcán, la ofrenda y ceremonia comunitarias, las plegarias, la comida y la fiesta, de acuerdo al ciclo ritual agrícola, somos testigos de las fechas importantes vinculadas con las entidades de la tierra, en las que el pueblo celebra al volcán.
Un pasaje del texto está dedicado a la Matlalcueye o “Malinche”, para poner de manifiesto que la veneración a los cerros pervive en el valle poblano-tlaxcalteca y forma parte de la cosmovisión mesoamericana. Incluye también una breve historia de la religión mesoamericana concretizada en el evento de petición de lluvias en la huasteca veracruzana, un dossier fotográfico que ilustra, entre otras cosas, algunos episodios de la ceremonia, monumentos, trazos arquitectónicos y representaciones antiguas asociadas al agua.
El texto finaliza con el análisis el territorio, su simbolismo sagrado, el espacio y las concepciones por las cuales está constituido, con el objetivo de mostrar cómo los espacios son emblemáticos, pues los seres sobrenaturales moran y se revelan en mitos y creencias. Por ello, el carácter sacro del culto a los cerros es de renovación constante entre entidades y hombres.
Ángeles Rubio Tapia, ed. Ven a bailar conmigo… El “baile de golpe” en cuatro municipios de Tierra Caliente. México: PACMYC/URCPI Michoacán/CNCA. 2014, 152 pp.
Authors: Estrada Hernández Daniel 
Published: March 2022

En este libro, María de los Ángeles Rubio Tapia nos habla del baile de golpe que se realiza a lo largo de la zona de Tierra Caliente, tanto en Michoacán como en Guerrero, presentando los frutos de varios años de trabajo de campo hecho en las localidades de Arteaga, Apatzingán, Coahuayutla y Zicuirán, La Huacana. En una primera parte y con el apoyo de varias entrevistas presentadas con una descripción muy ligera pero a la vez erudita, Ángeles Rubio nos da a conocer y reconocer qué es el “son”, en cuáles celebraciones se baila, cuál es la historia de los músicos, la instrumentación, la tabla –elemento fundamental para la realización para el baile de golpe-- y los bailadores. En un segundo momento realiza, con una sistematización única para este tipo de expresión, la descripción de las danzas, los pasos característicos de cada danzante y sus funciones dentro de su realización.
El libro contiene también un DVD como material complementario en el que se presenta dos documentales realizados por la misma Ángeles Rubio. El primero se titula igual que el libro y mantiene la misma estructura de este, lo que permite apreciar de manera más concreta los detalles de la instrumentación, ritmos, bailadores y los pasos que se describen en los diversos esquemas. El segundo tiene por nombre Son de la tierra y está conformado por diversas entrevistas y muestras musicales que inundarán al lector del ritmo de Tierra Caliente y de la empatía necesaria para entender la importancia dancística y musical de este territorio.
Preserved glomerular filtration rate in older people. A population-based study in the Southern Cone of Latin America
Authors: Musso Carlos Guido 
Published: March 2022

Introduction: Kidneys are affected by the aging process, usually suffering a progressive glomerular filtration rate (GFR) reduction of around 1 ml/year as of 30 years of age. Nevertheless, few older subjects show a stable GFR over time. This phenomenon has not been exhaustively studied, and even less in the Southern Cone. Aim: The aim was to estimate the prevalence of preserved GFR in a representative sample of older adults and explore the association between cardiovascular risk factors and preserved GFR in older individuals.
Methods: We used data from a cross-sectional survey of a random sample of 1571 participants aged 65–74 years from 4 cities of the Southern Cone. We describe the prevalence of eGFR ?80 ml/min/1.73 m2 and sociodemographic, biological, behavioral risk factors and medication use. Backward stepwise logistic regression analysis was used to study the effect of cardiovascular risk factors on eGFR ?80 ml/min.
Results: In this a study 962 had an eGFR >80 ml/min/1.73 m2 and 154 were healthy adults (Prevalence= 17.01 % [95%CI 14.5%; 19.9%]). The median eGFR in the full sample was 85.53 ml/min/1.73 m² (IQR: 73.12-91.26). The prevalence of eGFR >80 ml/min/1.73 m2 was higher among men. Overall, older adults with no cardiovascular risk factors and eGFR >80 ml/min/1.73 m2 were predominantly men and showed a lower prevalence of dyslipidemia.
Conclusion: In the present study was documented that there was 17% of healthy older individuals who have preserved glomerular filtration rate (eGFR > 80 ml/min/1.73 m 2) despite their advanced age.