bluuebunny/crossref_metadata_2025_split huggingface dataset:
How we established a multidisciplinary program for vascular anomalies
Authors: Borst Alexandra J. , Swerdlin Rachel F. , Phillips James D. , Hawkins C. Matthew , Briones Michael A. 
Published: September 2022

AbstractThe care of patients with vascular anomalies is quickly becoming a complex field requiring high‐quality, coordinated multidisciplinary care. In this article, we review the history of multidisciplinary care in this field, discuss the benefits of this model of care, and outline some of the essential components and structure of a successful vascular anomalies team. We provide an overview of two example programs and a roadmap for other centers to develop their own multidisciplinary vascular anomalies teams.
How we approach pediatric congenital chylous effusions and ascites
Authors: Nakano Taizo A. , Dori Yoav , Gumer Lindsey , Liptzin Deborah R. , Hill Lauren R. S. , Kulungowski Ann M. 
Published: September 2022

AbstractCongenital lymphatic leak may develop in patients with maldeveloped lymphatics and result in life‐threatening fluid and electrolyte imbalance, protein deficiency, and immunodeficiency. Rapid diagnosis and therapy are necessary to prevent these complications; however, the field lacks clinical trials to support standardized diagnostic treatment guidelines. We present our current multidisciplinary approach to the diagnosis and management of congenital lymphatic leak including chylous pleural effusions and ascites. Depending on the rate of lymphatic leak, therapy can range from observation with nutritional modifications to surgical and interventional procedures aimed to reduce lymphatic drainage. Modalities to image central and peripheral lymphatics have advanced considerably. Genetic variants and subsequent targets that drive lymphatic maldevelopment have expanded the repertoire of possible pharmacotherapeutic options.
Seeking virtual support: Digital technology use in adolescent and young adults with advanced cancer
Authors: Steineck Angela , Lau Nancy , Fladeboe Kaitlyn M. , Walsh Casey A. , Rosenberg Abby R. , Yi‐Frazier Joyce P. , Barton Krysta S. 
Published: September 2022

ABSTRACTBackgroundA cancer diagnosis, especially advanced cancer, interferes with adolescent/young adult (AYA) peer relationships. AYAs increasingly use digital technologies (i.e., social media, video games) as a social instrument; little is known about the role of digital technologies in the AYA cancer experience. The objective of this analysis was to describe the use and impact of digital technologies among AYAs with advanced cancer.ProcedureAs part of the “Exploring the Concept of a ‘Good Death’” study, semi‐structured interviews were conducted with 32 English‐speaking AYAs (14–25 years) with advanced cancer (relapsed/refractory disease, estimated survival <50%). Interviews were audio recorded, deidentified, and transcribed verbatim. Questions focused on communication and sources of psychosocial support. Directed content analysis was used for codebook creation. Three reviewers completed transcript coding and reconciled discrepancies. Thematic analysis identified hierarchical themes. The present analysis focused on the specific theme of “digital technologies as a support mechanism.”ResultsWhen asked about sources of support, social media and multiplayer online games were most often recognized by AYAs. Three themes emerged regarding the role of digital technologies: distraction, maintaining existing peer support, and connecting with peers with cancer. Two AYAs acknowledged negative consequences of social media.ConclusionsAYAs with advanced cancer cite digital technologies as a mechanism for maintaining and seeking peer support. Digital technologies may be leveraged to provide psychosocial support for AYAs with advanced cancer.
Safety analysis of high‐dose methotrexate in pediatric non‐Hodgkin lymphomas
Authors: Bernhardt M. Brooke , Brown Austin L. , Grim Austyn T. , Scheurer Michael E. , El‐Mallawany Nader Kim , Ozuah Nmazuo W. 
Published: September 2022

AbstractHigh‐dose methotrexate (HD‐MTX) with rigorous supportive care is essential to the treatment of pediatric non‐Hodgkin lymphomas (NHL). We describe the safety and tolerability of HD‐MTX in patients with NHL treated at our center. In our cohort of 46 patients, the majority had at least one course of delayed clearance and/or creatinine elevation. Additionally, more than one‐third of patients experienced an episode of grade ≥3 mucositis. Creatinine elevations and delayed clearance were independently associated with subsequent grade ≥3 mucositis. We advocate for greater availability of methotrexate monitoring to allow dose escalation of this essential modality around the world.
Cell‐free DNA screening for rare autosomal trisomies and segmental chromosome imbalances
Authors: Raymond Yvette C. , Fernando Shavi , Menezes Melody , Meagher Simon , Mol Ben W. , McLennan Andrew , Scott Fergus , Mizia Karen , Carey Karen , Fleming Gabrielle , Rolnik Daniel Lorber 
Published: September 2022

AbstractObjectiveTo assess the outcomes of pregnancies at high‐risk for rare autosomal trisomies (RATs) and segmental imbalances (SIs) on cell‐free DNA (cfDNA) screening.MethodA retrospective study of women who underwent cfDNA screening between September 2019 and July 2021 at three ultrasound services in Australia. Positive predictive values (PPVs) were calculated using fetal chromosomal analysis.ResultsAmong 23,857 women screened, there were 93 high‐risk results for RATs (0.39%) and 82 for SIs (0.34%). The PPVs were 3.8% (3/78, 95% CI 0.8%–10.8%) for RATs and 19.1% (13/68, 95% CI 10.6%–30.5%) for SIs. If fetuses with structural anomalies were also counted as true‐positive cases, the PPV for RATS increased to 8.5% (7/82, 95% CI 3.5%–16.8%). Among 85 discordant cases with birth outcomes available (65.4%), discordant positive RATs had a significantly higher proportion of infants born below the 10th and 3rd birthweight percentiles than expected (19.6% (p = 0.022) and 9.8% (p = 0.004), respectively), which was not observed in the SI group (2.9% < 10th (p = 0.168) and 0.0% <3rd (p = 0.305)).ConclusionThe PPVs for SI and RAT results are low, except when a structural abnormality is also present. Discordant positive RATs are associated with growth restriction.
Neoplastic malignant cord compression mimicking low back pain: A case report
Authors: Cataldi Fabio , Brindisino Fabrizio , Angilecchia Domenico , Andreani Alessandro , Giovannico Giuseppe 
Published: September 2022

AbstractBackgroundThe point prevalence of Cauda Equina Syndrome (CES) as a cause of Low Back Pain (LBP) is estimated at 0.04% in primary care, and it is reported as a complication in about 2% of patients with disc herniation. Compression of the cauda equina usually occurs as a result of disc prolapse. However, CES may be caused by any space‐occupying lesion, including spinal stenosis, neoplasms, cysts, infection, and osteophytes. First contact physiotherapists may encounter patients with early CES, as the clinical presentation of CES can mimic non‐specific LBP.Case presentationThis case report presents the medical history, diagnostic tests and relevant clinical data of a 52‐year‐old man complaining of LBP. The patient's medical history, his symptoms and the clinical findings led to the identification of a number of red flags (i.e. risk factors) suggestive of a non‐musculoskeletal condition. The patient was referred to the emergency department for further investigation. Having undergone several diagnostic tests, the patient was diagnosed with CES due to malignancy.ConclusionsThis case report highlights the importance of differential screening throughout the treatment period, in order to identify red flags that warrant further investigation and a referral to an appropriate specialist. Physiotherapy screening should include clinical reasoning, careful analysis of clinical presentation and symptom progression, in addition to appropriate referral for medical assessment and diagnostic imaging, if necessary.
A grape (Vitis vinifera L.) pomace water extract modulates inflammatory and immune response in SW‐480 cells and isolated mouse colon
Authors: Recinella Lucia , Chiavaroli Annalisa , Veschi Serena , Cama Alessandro , Acquaviva Alessandra , Libero Maria Loreta , Leone Sheila , Di Simone Simonetta Cristina , Pagano Ester , Zengin Gokhan , Menghini Luigi , Brunetti Luigi , Izzo Angelo Antonio , Orlando Giustino , Ferrante Claudio 
Published: September 2022

AbstractGrape (Vitis vinifera L.) pomace is a residue derived from the winemaking process, which contains bioactive compounds displaying noteworthy health‐promoting properties. The aim of the present study was to investigate the phenolic composition and protective effects of a water extract of grape pomace (WEGP) in colorectal cancer cell line SW480 and in isolated mouse colon exposed to Escherichia coli lipopolysaccharide (LPS). The extract decreased SW‐480 cell viability, as well as vascular endothelial factor A (VEGFA), hypoxia‐induced factor 1α (HIF1α), and transient receptor potential M8 (TRPM8) LPS‐induced gene expression. Moreover, the extract inhibited mRNA levels of nuclear factor kB (NFkB), cyclooxygenase (COX)‐2, tumor necrosis factor (TNF)α, interleukin (IL)‐6, IL‐1β, IL‐10, inducible nitric oxide synthase (iNOS), and interferon (IFN)γ, in isolated colon. Conversely, WEGP increased the gene expression of antioxidant catalase (CAT) and superoxide dismutase (SOD), in the same model. The modulatory effects exerted by WEGP could be related, at least in part, to the phenolic composition, with particular regards to the catechin level. Docking calculations also predicted the interactions of catechin toward TRPM8 receptor, deeply involved in colon cancer; thus further suggesting the grape pomace as a valuable source of bioactive extracts and phytochemicals with protective effects in the colon.
A multirobot system for autonomous deployment and recovery of a blade crawler for operations and maintenance of offshore wind turbine blades
Authors: Jiang Zhengyi , Jovan Ferdian , Moradi Peiman , Richardson Tom , Bernardini Sara , Watson Simon , Weightman Andrew , Hine Duncan 
Published: September 2022

AbstractOffshore wind farms will play a vital role in the global ambition of net zero energy generation. Future offshore wind farms will be larger and further from the coast, meaning that traditional human‐based operations and maintenance approaches will become infeasible due to safety, cost, and skills shortages. The use of remotely operated or autonomous robotic assistants to undertake these activities provides an attractive alternative solution. This paper presents an autonomous multirobot system which is able to transport, deploy and retrieve a wind turbine blade inspection robot using an unmanned aerial vehicle (UAV). The proposed solution is a fully autonomous system including a robot deployment interface for deployment, a mechatronic link‐hook module (LHM) for retrieval, both installed on the underside of a UAV, a mechatronic on‐load attaching module installed on the robotic payload and an intelligent global mission planner. The LHM is integrated with a 2‐DOF hinge that can operate either passively or actively to reduce the swing motion of a slung load by approximately 30%. The mechatronic modules can be coupled and decoupled by special maneuvers of the UAV, and the intelligent global mission planner coordinates the operations of the UAV and the mechatronic modules for synchronous and seamless actions. For navigation in the vicinity of wind turbine blades, a visual‐based localization merged with the location knowledge from Global Navigation Satellite System has been developed. A proof‐of‐concept system was field tested on a full‐size decommissioned wind‐turbine blade. The results show that the experimental system is able to deploy and retrieve a robotic payload onto and from a wind turbine blade safely and robustly without the need for human intervention. The vicinity localization and navigation system have shown an accuracy of 0.65 and 0.44 m in the horizontal and vertical directions, respectively. Furthermore, this study shows the feasibility of systems toward autonomous inspection and maintenance of offshore windfarms.
A probability‐based model to quantify the impact of hydropeaking on habitat suitability in rivers
Authors: Jelovica Bähar , Marttila Hannu , Ashraf Faisal Bin , Kløve Bjørn , Torabi Haghighi Ali 
Published: September 2022

AbstractA negative effect of hydropower on river environment includes rapid changes in flow and habitat conditions. Any sudden flow change could force fish to move towards a refuge area in a short period of time, causing serious disturbances in the life cycle of the fish. A probability‐based model was developed to quantify the impact of hydropeaking on habitat suitability for two fish species, brown trout (Salamo trutta) and Grayling (Thymallus thymallus). The model used habitat preference curves, river velocity and depth to develop the suitability maps. The suitability maps reveal that habitat suitability deteriorates as flow increases in the studied part of the river. The probability model showed that, on average, suitability indices are higher for adult grayling than juvenile trout in hydropeaking events in this part of the river. The method developed shows the potential to be used in river management and the evaluation of hydropeaking impacts in river systems affected by hydropower.
Transcriptomic Features in a Single Extracellular Vesicle via Single‐Cell RNA Sequencing
Authors: Luo Tao , Chen Si‐Yi , Qiu Zhi‐Xin , Miao Ya‐Ru , Ding Yue , Pan Xiang‐Yu , Li Yirong , Lei Qian , Guo An‐Yuan 
Published: September 2022

AbstractAlthough many studies have investigated functional molecules in extracellular vesicles (EVs), the exact number of ribonucleic acid molecules in a single‐EV is unknown. Therefore, it is critical to explore the transcriptomic features and heterogeneity at the level of a single‐EV. Here, using the 10x Genomics platform, the RNA cargos are profiled in single EVs derived from human K562 and mesenchymal stem cells. The key steps are labeling intact EVs using calcein‐AM, detecting the EV concentration via flow cytometry, and using the CB2 algorithm with adaptive thresholds to effectively distinguish real EVs from background. The gene number in a single‐EV varied from 6 to 148, with a mean of 52. Ribosomal genes, mitochondrial genes, and eukaryotic translation elongation factor 1 alpha has a high EV percentage in all EV samples. Hemoglobin genes are uniquely highly expressed in K562‐EVs, and cytoskeleton genes are enriched in MSC‐EVs. Ten or more clusters with different marker genes in each single‐EV dataset demonstrated EV heterogeneity. Moreover, integrating EVs and their parental cells reveal both EVs and cells in each cluster, indicating different cell origins of various EVs. To the best of the author's knowledge, this study provides the first high‐throughput transcriptome at the single‐EV level and improves the understanding of EVs.
Overview of the cyclic response of reinforced concrete members subjected to artificial chloride‐induced corrosion
Authors: Matthews Benjamin , Palermo Alessandro , Scott Allan 
Published: September 2022

AbstractReinforced concrete (RC) elements suffer continuous deterioration across their lifetime from in situ aggressive environmental factors. Chloride‐induced deterioration of the steel reinforcement presents significant repercussions on the mechanical and seismic behavior of affected RC members. This paper introduces and summarizes experimental work carried out at the University of Canterbury, investigating the long‐term implications of chloride‐induced deterioration on various mechanical properties. The impact of chloride corrosion on bond‐slip behavior, the cyclic flexural response of large‐scale RC piers, and the shear resistance of short RC columns, with particular focus on the latter, is reported. Results indicate that corrosion damage presents more severe consequences to the displacement ductility of RC columns than the load‐bearing capacity. Transverse reinforcement presents a much greater risk and vulnerability to deterioration, leading to a transition in failure mechanism from a ductile response to a brittle shear/shear‐bond failure. Reduced confinement negatively impacts the stress–strain response of the confined concrete and bond‐slip behavior in cracked members, where friction is relied upon as the primary load‐transfer mechanism once mechanical interlock is lost through the generation of rust by‐products and concrete splitting.
Diagnostic accuracy of pan‐enteric capsule endoscopy and magnetic resonance enterocolonography in suspected Crohn's disease
Authors: Brodersen Jacob Broder , Knudsen Torben , Kjeldsen Jens , Juel Mie Agerbæk , Rafaelsen Søren Rafael , Jensen Michael Dam 
Published: September 2022

AbstractBackground and AimsMagnetic resonance enterocolonography (MREC) and pan‐enteric capsule endoscopy (CE) offers visualization of the entire gastrointestinal tract in a single examination. We examined the diagnostic accuracy of MREC and CE in patients with suspected Crohn's disease (CD).MethodIn a prospective, blinded, multicenter study, we included patients with clinically suspected CD. Patients were examined with MREC, CE, and ileocolonoscopy (IC) within 2 weeks. The primary outcome was per patient sensitivity, specificity, and diagnostic accuracy for ileocolonic CD. IC served as reference standard.Results153 patients were included in the study and IC, MREC, and CE was performed in 152, 151, 133 patients, respectively. CD was diagnosed with IC in 59 (39%) patients (terminal ileum (TI) 22, colon 20, TI and colon 17). The sensitivity and specificity for diagnosing ileocolonic CD with MREC was 67.9% (CI 53.7–80.1) and 76.3% (CI 65.2–85.3) (TI 76.9% and 85.6%; colon 27% and 93%) compared to 87.5% (CI 73.2–95.8) and 87.8% (CI 78.2–94.3) with CE (TI 96.6% and 87.5%; colon 75.0% and 93.0%). The sensitivity of CE was superior to that of MREC (p = 0.02). The patient experienced discomfort was equal with CE and MREC and significantly less than with IC.ConclusionIn patients with suspected CD, CE has a high sensitivity for diagnosing CD in the TI and colon, which is superior to that of MREC. The sensitivity of MREC for diagnosing CD in the colon is poor. CE could be a patient‐friendly alternative to IC in selected patients with suspected CD.Registered at ClinicalTrials.gov: NCT03134586.
Effects of weather and landscape use on mourning dove population trends in North Dakota
Authors: Dinges Andrew J. , Szymanski Michael L. , Parent Chad J. 
Published: September 2022

AbstractMourning dove (Zenaida macroura) populations are believed to be declining throughout much of the United States since widespread population surveys were implemented in the mid‐1960s. However, results from the Mourning Dove Call‐Count Survey and North American Breeding Bird Survey indicate no trend for mourning doves in North Dakota. In addition, little is known about how climate and landscape factors may influence trends in mourning dove populations, especially in the northern extent of their breeding range. We used late‐summer roadside counts conducted in North Dakota from 1970–2017 (n = 3,368), along with information from National Oceanic and Atmospheric Administration (NOAA) weather stations and the Census of Agriculture (United State Department of Agriculture) to develop generalized linear mixed models to analyze trends and identify weather and landscape variables that may be affecting mourning dove populations in North Dakota. Our results indicated that mourning doves counted along roadside transects have declined over the last 50 years in northcentral, northeast, and southeast regions of North Dakota where agriculture activity is most intensive and total cropland currently makes up at least 65% of the total landscape. Conversely, in northwest, southwest, and southcentral regions of North Dakota, where cropland makes up less than 50% of the landscape, we detected no trends in mourning doves counted during the same period. In our weather and landscape model, area of harvested corn and soybeans had a negative effect on mourning doves counted ( = −0.174, SE = 0.029, 95% CI = −0.232, −0.116), whereas area of woodland had a positive effect on mourning dove abundance ( = 0.137, SE = 0.053, 95% CI = 0.032, 0.241). In addition, we found no evidence that temperature or precipitation were influencing mourning dove populations in North Dakota. Woodland habitat steadily declined in North Dakota during our study period. Additionally, the amount of corn and soybeans planted throughout the state has increased rapidly over the last 20 years, which has decreased cropland diversity, and this pattern of land use change is likely reducing food and cover during the nesting season. To halt declining mourning dove populations in intensively farmed regions, managers should implement conservation programs and private land initiatives that aim to provide a more balanced mix of cropland, grassland, and woodland, with reductions in corn and soybean acres.
A new candling procedure for thick and opaque eggs and its application to avian conservation management
Authors: Hall Clancy A. , Potvin Dominique A. , Conroy Gabriel C. 
Published: September 2022

AbstractThe ability to monitor developing avian embryos and their associated vascular system via candling enables the application of important reproductive management techniques. Egg candling facilitates the confirmation of egg viability throughout the incubation process and identification of a precise position on a vein for the safe extraction of blood. Blood samples may then be analysed to retrieve vital health and genetic information to assist in conservation management. However, the thick or opaque egg shell characteristics of some avian species prevents the observation of egg contents using traditional candling methods, thus limiting management options. This paper tests a novel method of preparing thick‐shelled or opaque eggs so that traditional egg candling and blood extraction methods may be applied. Eggs from captive emu (Dromaius novaehollandiae, Latham 1790) and southern cassowary (Casuarius casuarius johnsonii, Linnaeus 1758) were obtained, and partial fenestration was performed on two areas of shell either before incubation or at ⅓ of incubation. Hatchability and weight loss were examined as a measure of effect of the fenestration process on the developing embryo. Clear observation of vascular development was successful in 97% of viable fenestrated eggs, without affecting hatchability or weight loss. Blood samples were taken from developing embryos and DNA was successfully extracted for proof of concept of this new technique. The ability to observe vascular development and monitor the developing embryo in thick and opaque eggs will significantly improve both in situ and ex situ population management options such as in ovo sexing in species of concern.
The Collapsing Compass
Authors: Ben-Ari Mordechai 
Published: September 2022

AbstractA modern compass is a fixed compass: the distance between the two legs can be fixed so that it is possible to copy a line segment or a circle from one position to another (Fig. 1.1a).Euclid used a collapsing compass where a fixed distance cannot be maintained (Fig. 1.1b). Teachers often use a collapsing compass consisting of a marker tied to a string that is used to construct a circle on a whiteboard. It is impossible to maintain a fixed length when the compass is removed from the whiteboard.
The Axioms of Origami
Authors: Ben-Ari Mordechai 
Published: September 2022

AbstractOrigami, the art of paper folding, was developed several centuries ago in Japan and nowhas aworldwide following. In the late twentieth century the mathematical theory of origami was developed. Its foundation is a set of seven axioms, the Huzita–Hatori axioms, named after Humiaki Huzita who formalized the first six axioms andKoshiro Hatori who found the seventh. Jacques Justin published all seven axioms several years before Huzita and Hatori, and Margherita P. Beloch formulated the sixth axiom in 1936. Nevertheless, the axioms as known as the Huzita-Hatori axioms.