bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbial Response to Coastal-Offshore Gradients in Taiwan Straits: Community Metabolism and Total Prokaryotic Abundance as Potential Proxies
Authors: Wan Lingling , Caruso Gabriella , Cao Xiuyun , Song Chunlei , Maimone Giovanna , Rappazzo Alessandro Ciro , Laganà Pasqualina , Zhou Yiyong 
Published: May 2022

AbstractLocated between the South and the East China Sea, the Taiwan Straits (TWS) are a marine shelf-channel area, with unique hydrological and geomorphological features affected by rivers inflow and with recent algal blooms with red tide events. This study aimed at assessing microbial distribution and function and their modulation in response to environmental gradients. Surface (0.5 m) water samples from 16 stations along five north to south transects were collected; total prokaryotic abundance by epifluorescence microscope and carbon substrate utilization patterns by Biolog Ecoplates were estimated. Spatially, a patchy microbial distribution was found, with the highest microbial metabolic levels and prokaryotic abundance in the TWS area between Minjiang River estuary and Pingtan Island, and progressive decreases towards offshore stations. Complex carbon sources and carbohydrates were preferentially metabolized. This study provides a snapshot of the microbial abundance and activity in TWS as a model site of aquatic ecosystems impacted from land inputs; obtained data highlights that microbial metabolism is more sensitive than abundance to environmental changes.
Tibial plateau fractures: three dimensional fracture mapping and morphologic measurements
Authors: Yao Peifeng , Gong Maoqi , Shan Lei , Wang Dong , He Yuanming , Wang Hanzhou , Zhou Junlin 
Published: May 2022

Abstract
Purpose
The injury mechanisms and classifications of tibial plateau fractures (TPFs) are still controversial. The aim of this study is to show 3D fracture mapping of different types of tibial plateau fractures. Moreover, combined with Schatzker and ten-segment classification, we aimed to analyze the injury frequency and characteristics of different segments.

Methods
In total, 346 patients with TPFs treated at level I trauma centres from 2017 to 2021 were reviewed. The CT files of the included cases were typed and categorized. 3D reconstruction of TPFs patients’ CT files were performed using software. All fracture lines were superimposed on the standard model by the software to create TPFs 3D fracture mapping.

Results
This study included 204 male and 142 female patients (average age, 47 years [range, 18 to 83 years]) with a tibial plateau fracture. Using the Schatzker classification, we found 39 type I (11.27%), 103 type II (29.77%), nine type III (2.60%), 71 type IV (20.52%), 52 type V (15.03%), 59 type VI (17.05%) fractures, and 13 others (3.76%). The density areas of fracture lines are mainly located in the ALC and PLC segments (74.3%, 69.1%). In different views, fracture lines of different Schatzker types showed distinct distribution characteristics.

Conclusions
Schatzker classification combined with 3D fracture mapping provides a new presentation of tibial plateau fracture morphology. According to the 3D fracture mapping, different types of TPFs have distinctly different distribution characteristics of fracture lines. There are significant differences between different types of fracture injury segments.
Reliability of estimating left ventricular ejection fraction in clinical routine: a validation study of the SWEDEHEART registry
Authors: Lenell Joel , Lindahl Bertil , Karlsson Per , Batra Gorav , Erlinge David , Jernberg Tomas , Spaak Jonas , Baron Tomasz 
Published: May 2022

Abstract
Objective
Patients hospitalized with acute coronary syndrome (ACS) in Sweden routinely undergo an echocardiographic examination with assessment of left ventricular ejection fraction (LVEF). LVEF is a measurement widely used for outcome prediction and treatment guidance. The obtained LVEF is categorized as normal (> 50%) or mildly, moderately, or severely impaired (40–49, 30–39, and < 30%, respectively) and reported to the nationwide registry for ACS (SWEDEHEART). The purpose of this study was to determine the reliability of the reported LVEF values by validating them against an independent re-evaluation of LVEF.

Methods
A random sample of 130 patients from three hospitals were included. LVEF re-evaluation was performed by two independent reviewers using the modified biplane Simpson method and their mean LVEF was compared to the LVEF reported to SWEDEHEART. Agreement between reported and re-evaluated LVEF was assessed using Gwet’s AC2 statistics.

Results
Analysis showed good agreement between reported and re-evaluated LVEF (AC2: 0.76 [95% CI 0.69–0.84]). The LVEF re-evaluations were in agreement with the registry reported LVEF categorization in 86 (66.0%) of the cases. In 33 (25.4%) of the cases the SWEDEHEART-reported LVEF was lower than re-evaluated LVEF. The opposite relation was found in 11 (8.5%) of the cases (p < 0.005).

Conclusion
Independent validation of SWEDEHEART-reported LVEF shows an overall good agreement with the re-evaluated LVEF. However, a tendency towards underestimation of LVEF was observed, with the largest discrepancy between re-evaluated LVEF and registry LVEF in subjects with subnormal LV-function in whom the reported assessment of LVEF should be interpreted more cautiously.

Graphical abstract
Influence of rotator cuff preload on fracture configuration in proximal humerus fractures: a proof of concept for fracture simulation
Authors: Lenz Maximilian , Kahmann Stephanie , Behbahani Mehdi , Pennig Lenhard , Hackl Michael , Leschinger Tim , Müller Lars Peter , Wegmann Kilian 
Published: May 2022

Abstract
Introduction
In regard of surgical training, the reproducible simulation of life-like proximal humerus fractures in human cadaveric specimens is desirable. The aim of the present study was to develop a technique that allows simulation of realistic proximal humerus fractures and to analyse the influence of rotator cuff preload on the generated lesions in regards of fracture configuration.

Materials and methods
Ten cadaveric specimens (6 left, 4 right) were fractured using a custom-made drop-test bench, in two groups. Five specimens were fractured without rotator cuff preload, while the other five were fractured with the tendons of the rotator cuff preloaded with 2 kg each. The humeral shaft and the shortened scapula were potted. The humerus was positioned at 90° of abduction and 10° of internal rotation to simulate a fall on the elevated arm. In two specimens of each group, the emergence of the fractures was documented with high-speed video imaging. Pre-fracture radiographs were taken to evaluate the deltoid-tuberosity index as a measure of bone density. Post-fracture X-rays and CT scans were performed to define the exact fracture configurations. Neer’s classification was used to analyse the fractures.

Results
In all ten cadaveric specimens life-like proximal humerus fractures were achieved. Two III-part and three IV-part fractures resulted in each group. The preloading of the rotator cuff muscles had no further influence on the fracture configuration. High-speed videos of the fracture simulation revealed identical fracture mechanisms for both groups. We observed a two-step fracture mechanism, with initial impaction of the head segment against the glenoid followed by fracturing of the head and the tuberosities and then with further impaction of the shaft against the acromion, which lead to separation of the tuberosities.

Conclusion
A high energetic axial impulse can reliably induce realistic proximal humerus fractures in cadaveric specimens. The preload of the rotator cuff muscles had no influence on initial fracture configuration. Therefore, fracture simulation in the proximal humerus is less elaborate. Using the presented technique, pre-fractured specimens are available for real-life surgical education.

Level of Evidence
III.
Exhumation of a migmatitic unit through self-enhanced magmatic weakening enabled by tectonic contact metamorphism (Gruf complex, Central European Alps)
Authors: Mintrone M. , Galli A. , Schmidt M. W. 
Published: May 2022

AbstractThe Central Alpine lower crustal migmatitic Gruf complex was exhumed in contact to the greenschist-grade Chiavenna ophiolite and gneissic Tambo nappe leading to a lateral gradient of ~ 70 °C/km within the ophiolite. The 14 km long, E-W striking subvertical contact now bridges metamorphic conditions of ~ 730 °C, 6.6 kbar in the migmatitic gneisses and ~ 500 °C, 4.2 kbar in the serpentinites and Tambo schists 2–4 km north of the contact. An obvious fault, mylonite or highly sheared rock that could accommodate the ~ 8.5 km vertical displacement is not present. Instead, more than half of the movement was accommodated in a 0.2–1.2 km thick orthogneiss of the Gruf complex that was heterogeneously molten. Discrete bands with high melt fractions (45–65%) now contain variably stretched enclaves of the adjacent MOR-derived amphibolite. In turn, the adjacent amphibolites exhibit tonalitic in-situ leucosomes and dikes i.e., were partially molten. The H2O necessary for fluid-assisted melting of the orthogneiss and amphibolites was likely derived from the tectonic contact metamorphism of the Chiavenna serpentinites, at the contact now in enstatite + olivine-grade. U–Pb dating of zircons shows that partial melting and diking occurred at 29.0–31.5 Ma, concomitant with the calc-alkaline Bergell batholith that intruded the Gruf. The major driving forces of exhumation were hence the strong regional North–South shortening in the Alpine collisional belt and the buoyancy provided by the Bergell magma. The fluids available through tectonic contact metamorphism led to self-enhanced magmatic weakening and concentration of movement in an orthogneiss, where melt-rich bands provided a low friction environment. Continuous heating of the originally greenschist Chiavenna ophiolite and Tambo gneisses + schists by the migmatitic Gruf complex during differential uplift explains the skewed temperature profile, with intensive contact heating in the ophiolite but little cooling in the portion of the now-exposed Gruf complex.
Introduction of Small Stitch Small Bite technique: a retrospective long-term follow-up
Authors: Söderbäck Harald , Masood Arslan , Leo Jonas , Sandblom Gabriel 
Published: May 2022

Abstract
Purpose
Standardization of abdominal wall closure is suggested to improve quality and reduce the risk for late abdominal wall complications. The purpose of this study was to explore the impact of a structured introduction of guidelines for abdominal wall closure on the rates of incisional hernia and wound dehiscence.

Methods
All procedures performed via a midline incision in 2010–2011 and 2016–2017 at Capio St Göran’s Hospital were identified and assessed for complications and risk factors.

Results
Six hundred two procedures were registered in 2010–2011, and 518 in 2016–2017. Four years after the implementation of new guidelines, 93% of procedures were performed using the standardized technique. There was no significant difference in the incidence of incisional hernia or wound dehiscence between the groups. In multivariate Cox proportional hazard analysis, BMI > 25, wound dehiscence, and postoperative wound infection were found to be independent risk factors for incisional hernia (all p < 0.05). In multivariate logistic regression analysis, male gender and chronic obstructive pulmonary disease were risk factors for wound dehiscence (both p < 0.05).

Conclusions
The present study failed to show a significant improvement in rates of incisional hernia and wound dehiscence after the introduction of Small Stitch Small Bites. When introducing a new standardized technique for closing the abdomen, education and structural implementation of guidelines may have an impact in the long run. The risk factors identified should be taken into consideration when closing a midline incision to identify patients with high risk.
Comparison of pleural drain amylase and serum C-reactive protein for early detection of intrathoracic esophago-gastric anastomotic leaks
Authors: Andreatta Erika , Buogo Alberto , Asti Emanuele , Boveri Sara , Bonavina Luigi 
Published: May 2022

Abstract

Introduction
Early detection of anastomotic leaks following esophagectomy has the potential to reduce hospital length of stay and mortality. The aim of this study was to compare the predictive value of pleural drain amylase and serum C-reactive protein for the early diagnosis of leak.

Methods
A retrospective observational cohort study was conducted on 121 patients who underwent Ivor Lewis esophagectomy and intrathoracic gastric conduit reconstruction. Pleural drain amylase levels were measured daily until postoperative day (POD) 5 and compared with CRP values measured on POD 3, 5, and 7. Specificity and sensitivity for both tests, and the respective ROC curves, were calculated.

Results
Anastomotic leak occurred in 12 patients. There was a significant statistical association between pleural drain amylase and serum CRP levels and the presence of anastomotic leakage. Pleural drain amylase cutoff of 209 IU/L on POD 2 yielded a sensitivity of 75% and a specificity of 94% (AUC = 0.813), whereas CRP cutoff value of 22.5 mg/dL on POD 3 yielded a sensitivity of 56% and a specificity of 92% (AUC = 0.772). The negative likelihood ratio of pleural drain amylase was 0.27 and 0.12 on POD 2 and 5, respectively. There was no statistically significant difference between ROC curves of amylase and CRP on POD 3 and 5 (p = 0.79 and p = 0.14, respectively).

Conclusions
Pleural drain amylase seems more efficient than serum CRP for early detection of esophago-gastric anastomotic leak. The practice of monitoring drain amylase and CRP may allow safer implementation of enhanced postoperative recovery pathway.
Frailty assessment tools predict perioperative outcome in elderly patients with endometrial cancer better than age or BMI alone: a retrospective observational cohort study
Authors: Anic Katharina , Flohr Friedrich , Schmidt Mona Wanda , Krajnak Slavomir , Schwab Roxana , Schmidt Marcus , Westphalen Christiane , Eichelsbacher Clemens , Ruckes Christian , Brenner Walburgis , Hasenburg Annette , Battista Marco Johannes 
Published: May 2022

Abstract
Objective
Five commonly used global health assessment tools have been evaluated to identify and assess the preoperative frailty status and its relationship with perioperative in-hospital complications and transfusion rates in older women with endometrial cancer (EC).

Methods
Preoperative frailty status was examined by the G8 questionnaire, the Eastern Cooperative Oncology Group performance status, the Charlson Comorbidity Index and the American Society of Anesthesiologists Physical Status System, as well as the Lee-Schonberg prognostic index. The main outcome measures were perioperative laboratory values, intraoperative surgical parameters and immediately postoperative complications.

Results
153 consecutive women ≥ 60 years with all stages of EC, who received primary elective surgery at the University Medical Center Mainz between 2008 and 2019 were classified with selected global health assessment tools according to their preoperative performance status. In contrast to conventional prognostic parameters like older age and higher BMI, increasing frailty was significantly associated with preoperative anemia and perioperative transfusions (p < 0.05). Moreover, in patients preoperatively classified as frail significantly more postoperative complications (G8 Score: frail: 20.7% vs. non-frail: 6.7%, p = 0.028; ECOG: frail: 40.9% vs. non-frail: 2.8%, p = 0.002; and CCI: frail: 25.0% vs. non-frail: 7.4%, p = 0.003) and an increased length of hospitalization were recorded. According to propensity score matching, the risk for developing postoperative complications for frail patients was approximately two-fold higher, depending on which global health assessment tool was used.

Conclusions
Preoperatively assessed frailty significantly predicts post-surgical morbidity rates in contrast to conventionally used single prognostic parameters such as age or BMI. A standardized preoperative assessment of frailty in the routine work-up might be beneficial in older cancer patients before major surgery to include these patients in a prehabilitation program with nutrition counseling and physiotherapy to adequately assess the perioperative risk.
Top 10 research priorities in colorectal cancer: results from the Colorectal Cancer Priority-Setting Partnership
Authors: Klotz Rosa , Holze Magdalena , Dörr-Harim Colette , Grohmann Erich , Nied Barbara , Lebert Burkhard , Weg-Remers Susanne , Lutz Claudia , Meißler Karin , Schloss Patrick , Ullrich Charlotte , Frankenhauser Susanne , Lutter Heidi , Bühler Diedrich , Ahmed Azaz , Gronlund Toto , Mihaljevic André L. ,   for the Forschungspartnerschaft Darmkrebs (www.forschungspartnerschaft.de), Mihaljevic André , Klotz Rosa , Dörr-Harim Colette ,   Steering Group Forschungspartnerschaft Darmkrebs/Priority Setting Colorectal Cancer, Bühler Diedrich , Dörr-Harim Colette , Frankenhauser Susanne , Gapp-Frasch Sylvia , Grohmann Erich , Helmstädter Volker , Hey Christa , Hey Werner , Klotz Rosa , Mihaljevic André , Lebert Burkhard , Lutz Claudia , Lutter Heidi , Lutz Claudia , Meißler Karin , Nied Barbara , Schloss Patrick , Stegmüller Susanne , Stünzi Peter , Trabold-Hauk Angelika , Ullrich Charlotte , Weg-Remers Susanne , Wensing Michel 
Published: May 2022

AbstractBackgroundColorectal cancer (CRC) is the third most frequent cause of cancer death in the word. Which aspects of research into CRC should be accorded the highest priority remains unclear, because relevant stakeholders, such as patients, nurses, and physicians, played hardly any part in the development of research projects. The goal in forming the CRC Priority-Setting Partnership (PSP) was to bring all relevant stakeholders together to identify and prioritize unresolved research questions regarding the diagnosis, treatment, and follow-up of CRC.MethodsThe CRC PSP worked in cooperation with the British James Lind Alliance. An initial nationwide survey was conducted, and evidence uncertainties were collected, categorized, summarized, and compared with available evidence from the literature. The as-yet unresolved questions were (provisionally) ranked in a second national wide survey, and at a concluding consensus workshop all stakeholders came together to finalize the rankings in a nominal group process and compile a top 10 list.ResultsIn the first survey (34% patients, 51% healthcare professionals, 15% unknown), 1102 submissions were made. After exclusion of duplicates and previously resolved questions, 66 topics were then ranked in the second survey (56% patients, 39% healthcare professionals, 5% unknown). This interim ranking process revealed distinct differences between relatives and healthcare professionals. The final top 10 list compiled at the consensus workshop covers a wide area of research topics.ConclusionAll relevant stakeholders in the CRC PSP worked together to identify and prioritize the top 10 evidence uncertainties. The results give researchers and funding bodies the opportunity to address the most patient-relevant research projects. It is the first detailed description of a PSP in Germany, and the first PSP on CRC care worldwide.
Linial for lists
Authors: Maus Yannic , Tonoyan Tigran 
Published: May 2022

AbstractLinial’s famous color reduction algorithm reduces a given m-coloring of a graph with maximum degree $$\varDelta $$
Δ
to an $$O(\varDelta ^2\log m)$$

O
(

Δ
2

log
m
)

-coloring, in a single round in the LOCAL model. We give a similar result when nodes are restricted to choose their color from a list of allowed colors: given an m-coloring in a directed graph of maximum outdegree $$\beta $$
β
, if every node has a list of size $$\varOmega (\beta ^2 (\log \beta +\log \log m + \log \log |{\mathcal {C}}|))$$

Ω
(

β
2

(
log
β
+
log
log
m
+
log
log
|
C
|
)
)

from a color space $${\mathcal {C}}$$
C
then they can select a color in two rounds in the LOCAL model. Moreover, the communication of a node essentially consists of sending its list to the neighbors. This is obtained as part of a framework that also contains Linial’s color reduction (with an alternative proof) as a special case. Our result also leads to a defective list coloring algorithm. As a corollary, we improve the state-of-the-art truly local$$({\text {deg}}+1)$$

(
deg
+
1
)

-list coloring algorithm from Barenboim et al. (PODC, pp 437–446, 2018) by slightly reducing the runtime to $$O(\sqrt{\varDelta \log \varDelta })+\log ^* n$$

O

(

Δ
log
Δ

)

+

log
∗

n

and significantly reducing the message size (from $$\varDelta ^{O(\log ^* \varDelta )}$$

Δ

O
(

log
∗

Δ
)

to roughly $$\varDelta $$
Δ
). Our techniques are inspired by the local conflict coloring framework of Fraigniaud et al. (in: FOCS, pp 625–634, 2016).
Totally extraperitoneal laparoscopic inguinal hernia repair post-radical prostatectomy
Authors: Watt Imogen , Bartlett Adam , Dunn John , Bowker Andrew 
Published: May 2022

Abstract
Background
Previous radical prostatectomy (RP) is considered a relative contraindication to the laparoscopic approach for inguinal hernia repair (LIHR). This study aimed to compare feasibility, safety and outcomes for patients undergoing totally extraperitoneal (TEP) LIHR who have previously undergone RP.

Methods
This single surgeon, case–control study was performed using a prospective database of all patients undergoing TEP LIHR between 1995 and 2020. Patients who underwent previous RP were identified and compared to matched controls. Pre-operative, operative and post-operative data were analysed. The type of RP, open, laparoscopic or robotic, was identified and operative outcomes compared between the three groups.

Results
6532 LIHR cases were identified. 165 had previously undergone RP and 6367 had undergone primary LIHR without prior RP. The groups were matched for age, demographics and co-morbidities. All operations were commenced laparoscopically, three converted to open in the LIHR + RP group and none in the LIHR group. Median operative time in patients with previous RP was longer, for unilateral (40 min vs. 21 min, p < 0.0001) and bilateral (71 vs. 30 min, p < 0.0001) LIHR. The majority of cases were performed as day stay procedures. There was no difference in immediate recovery parameters including time to discharge, complication rates, return to normal function, return to driving or post-operative analgesia. At 3 months of follow-up there was no difference in hernia recurrence for unilateral (2/128 vs 6/2234, p = 0.0658) or bilateral (0/24 vs 3/1490, p ≥ 0.999) LIHR, nor chronic pain as measured by patient awareness or restriction of activity. No differences in operative and post-operative outcomes were identified between the three types of RP, other than difference in operative time (p = 0.0336).

Conclusions
Previous RP should not be an absolute contraindication for TEP LIHR. Although previous RP adds complexity, in experienced hands TEP LIHR can be done safely, with outcomes equivalent to patients who have not previously undergone RP.