bluuebunny/crossref_metadata_2025_split huggingface dataset:
The short‐term economic consequences of COVID‐19: Occupation tasks and mental health in Canada
Authors: Beland Louis‐Philippe , Brodeur Abel , Mikola Derek , Wright Taylor 
Published: March 2022

AbstractIn this paper, we study the effect of COVID‐19 on the labour market and reported mental health of Canadians. To better understand the effect of the pandemic on the labour market, we build indexes for whether workers: (i) are relatively more exposed to disease, (ii) work in proximity to co‐workers, (iii) are essential workers and (iv) can easily work remotely. Our estimates suggest that the impact of COVID‐19 was significantly more severe for workers that work in proximity to co‐workers and those more exposed to disease who are not in the health sector, while the effects are less severe for essential workers and workers that can work remotely. Last, using the Canadian Perspective Survey Series, we observe that reported mental health is significantly lower among some of the most affected workers such as women and less‐educated workers. We also document that those who were absent from work because of COVID‐19 are more concerned with meeting their financial obligations and with losing their job than those who continue working outside their home.
Knockdown of circ_0055412 promotes cisplatin sensitivity of glioma cells through modulation of CAPG and Wnt/β‐catenin signaling pathway
Authors: Zhou Qingjiu , Fu Qiang , Shaya Mahati , Kugeluke Yalikun , Li Shaoshan , Dilimulati Yisireyili 
Published: March 2022

AbstractIntroductionGlioma is the most frequent primary cerebral tumor in adults. Recent evidence has suggested that circular RNAs (circRNAs) are associated with the pathological processes in glioma. In our study, we aimed to investigate the function and mechanism of circ_CAPG (circ_0055412) in glioma.MethodsFirstly, circ_0055412 expression was examined through RT‐qPCR analysis. Loss‐of‐function assays and animal experiments were implemented to evaluate the role of circ_0055412 on cisplatin resistance of glioma cells. Moreover, mechanism assays were done to probe into the regulatory mechanism of circ_0055412 in glioma cells.ResultsCirc_0055412 was found to be notably upregulated in glioma cells. Moreover, depletion of circ_0055412 enhanced cisplatin sensitivity of glioma cells in vitro and in vivo. Moreover, circ_0055412 recruited eukaryotic translation initiation factor 4A3 (EIF4A3) protein to stabilize capping actin protein, gelsolin like (CAPG) mRNA. Furthermore, circ_0055412 served as a sponge for microRNA‐330‐3p (miR‐330‐3p) and regulated nuclear factor of activated T cells 3 (NFATC3) expression to activate the transcription of catenin beta 1 (CTNNB1), thus participating in the activation of Wnt/β‐catenin signaling pathway.ConclusionCirc_0055412 contributed to cisplatin resistance of glioma cells via stabilizing CAPG mRNA and modulating Wnt/β‐catenin signaling pathway. This finding might provide novel information for the treatment of glioma.
Movement and habitat use of non‐breeding Semipalmated Sandpiper (Calidris pusilla) at the Banco dos Cajuais in Northeast Brazil
Authors: Linhart Rebeca C. , Hamilton Diana J. , Paquet Julie , N. Monteiro J. Onofre , P. Ramires Gabriela , Mobley Jason A. 
Published: March 2022

AbstractSemipalmated sandpipers are Arctic breeding shorebirds that migrate to South America during the non‐breeding season. Little work has been done to understand the daily movements, foraging habits and metabolic state of this species on stationary nonbreeding grounds. Our work was conducted at the Banco dos Cajuais Western Hemisphere Shorebird Reserve Network (WHSRN) site in Northeast Brazil. We captured semipalmated sandpipers in February and March 2019 and 2020 and attached nanotags to monitor their daily movements. Blood samples were taken to measure plasma triglycerides (an index of fattening rate). We also conducted behavioral observations on foraging birds. Using tracking data we determined that most semipalmated sandpipers appeared to use sunrise/sunset as an indicator for movement between salina and tidal flat habitats, and a smaller portion used tidal height. We found birds spent similar amounts of time foraging on tidal flats and in salinas, though different foraging modes were used. Plasma triglyceride measures suggest semipalmated sandpipers had not started preparing to migrate when sampled. We successfully tracked semipalmated sandpipers to North America during northward migration in 2020, detecting eight within the United States. Tracking results suggest many stopped elsewhere in South America to fuel for migration, though some may have fueled at the Banco dos Cajuais. By demonstrating substantial use of both natural and altered habitats in the region by migrant semipalmated sandpipers, these data highlight the need for broader conservation measures throughout coastal regions of South America.
Cardiovascular efficacy of liraglutide and semaglutide in individuals with diabetes and peripheral artery disease
Authors: Verma Subodh , Al‐Omran Mohammed , Leiter Lawrence A. , Mazer C. David , Rasmussen Søren , Saevereid Hans A. , Sejersten Ripa Maria , Bonaca Marc P. 
Published: March 2022

AbstractAimTo evaluate the cardiovascular (CV) efficacy of liraglutide and semaglutide in patients with type 2 diabetes (T2D) and peripheral artery disease (PAD).Materials and MethodsLEADER and SUSTAIN 6 trials investigated subcutaneous liraglutide (≤1.8 mg/day) and semaglutide (0.5 or 1.0 mg/week), respectively, versus placebo in patients with T2D and high CV risk (median follow‐up: 3.8 and 2.1 years, respectively). The primary outcome was a composite of CV death, non‐fatal myocardial infarction or non‐fatal stroke (major adverse CV event [MACE]) according to the presence of PAD at baseline.ResultsOverall, 1184/9340 (12.7%) patients in LEADER and 460/3297 (14.0%) in SUSTAIN 6 had PAD at baseline. Patients with PAD were at an ~35% increased risk of MACE versus those without (LEADER: hazard ratio [HR] 1.36, 95% confidence interval [CI] 1.17‐1.58; SUSTAIN 6: HR 1.33, 95% CI 0.94‐1.83). The effects of both therapies on MACE were consistently beneficial in patients with PAD (liraglutide: HR 0.77, 95% CI 0.58‐1.01; semaglutide: 0.61, 0.33‐1.13) and without (liraglutide: HR 0.89, 95% CI 0.79‐1.00; semaglutide: HR 0.77, 95% CI 0.58‐1.01; Pinteraction = .34 for liraglutide and .49 for semaglutide). Absolute risk reductions for MACE were higher in patients with PAD (liraglutide: 4.13%‐point, 95% CI −0.15‐8.42; semaglutide: 4.63%‐point, 95% CI −0.58‐9.84) versus without (liraglutide:1.42%‐point, 95% CI −0.03‐2.87; semaglutide: 1.90%‐point, 95% CI 0.00‐3.80).ConclusionBoth liraglutide and semaglutide reduce MACE with consistent CV efficacy regardless of PAD status.
Nerve regeneration in rat peripheral nerve allografts: An assessment of the role of endogenous neurotrophic factors in nerve cryopreservation and regeneration
Authors: Zhang Song , Zhou Ying , Xian Hua , Shi Yifeng , Liu Yunxiao , Li Zijian , Huang Yingru 
Published: March 2022

AbstractPeripheral nerve injury is a common clinical problem that often leads to significant functional impairment or even complete paralysis. Allograft has been proposed as a potential repair strategy for peripheral nerve injuries. Furthermore, peripheral nerve cryopreservation may result in nearly unlimited supply of grafts. However, the concentration of neurotrophic factors secreted by Schwann cells (SCs) in the local micro‐environment after transplantation may not be sufficient for the survival of neuronal soma and axonal regeneration. Here, we investigated the effect of endogenous neurotrophic factors (ENTFs) on nerve regeneration in rats after the allograft of a cryopreserved sciatic nerve. ENTFs were highly expressed in the sciatic nerves pretreated for 14 days. Although the number of surviving cells in the sciatic nerves and their immunogenicity were low in the 14‐day group after 4 weeks of cryopreservation, they continued to express high levels of ENTFs in vitro. At 1 week postoperation, the 14‐day Allo group showed low plasma levels of interleukin‐2, interferon‐γ and tumour necrosis factor‐alpha and low cellular immune response. At 20 weeks postoperation, nerve regeneration and functional recovery in the 14‐day Allo group was similar to that in the fresh isograft group but better than that in the cryopreserved‐fresh allograft and fresh allograft groups. Thus, ENTFs were induced in vitro after pretreatment of the sciatic nerve. Following cryopreservation, the sciatic nerves with high levels of ENTFs continued to express high levels of ENTFs in vitro. The immune response after allograft was weak, which promoted recipient nerve regeneration.
Global insights on managing fishery systems for the three pillars of sustainability
Authors: Garlock Taryn , Anderson James L. , Asche Frank , Smith Martin D. , Camp Edward , Chu Jingjie , Lorenzen Kai , Vannuccini Stefania 
Published: March 2022

AbstractThere is growing recognition that fisheries should be managed for all three pillars of sustainability: economic, social and environmental sustainability. Limited quantitative evidence exists on factors supporting social sustainability, much less factors that contribute to multiple dimensions of sustainability. To develop a broader understanding of the factors that influence the performance of fishery management systems in environmental, economic and social pillars, we examine 11 input factors conjectured to contribute to successful fisheries using a global dataset of 145 fisheries case studies. The analysis indicates that management approaches are cross‐cutting and contribute to multiple dimensions of sustainability to varying extents. Importantly, factors exogenous to fisheries management can be as important as fisheries management, suggesting collaboration of fisheries institutions with other public and private institutions is important for sustainable fisheries development.
Innovation drivers in regions. Does urbanization matter?
Authors: Ciołek Dorota , Golejewska Anna , Zabłocka‐Abi Yaghi Adriana 
Published: March 2022

AbstractMost research aimed at identifying factors stimulating innovation activity at the regional level poorly takes into account the fact that the importance of various factors may differ in regions with different degrees of urbanization. Moreover, there is still few comprehensive empirical studies identifying innovation systems as regional 'ecosystems', which significantly expands the set of potential factors influencing innovation activity. In the present study, we address this research gap on the example of Polish NUTS 3 regions. Using econometric models of panel data we analyse regional innovation ecosystems from the perspective of quintuple helix components. It was proven that the impact of the various elements depends on the urbanization degree. One of the findings is that, while the science sector turned out to be one of the most important for urban regions and social capital is key for rural areas, the road infrastructure appears to be important for intermediate regions. The results obtained may constitute the basis for differentiation of policies addressed to selected, more or less urbanised areas, not only in terms of factors reflecting the enterprises directly but also in such aspects as science, administration, territorial conditions, natural environment and other elements of the enterprise environment.
Early prenatal diagnosis of Hb Lepore Boston‐Washington and β‐thalassemia on fetal celomatic DNA
Authors: Giambona Antonino , Leto Filippo , Cassarà Filippo , Tartaglia Viviana , Marchese Giuseppe , Orlandi Emanuela , Cigna Valentina , Picciotto Francesco , Maggio Aurelio , Vinciguerra Margherita 
Published: March 2022

AbstractIntroductionAnalysis of fetal DNA in at risk couples for thalassemia is performed from fetal trophoblast or amniotic fluid cells. Although these procedures are in common use, the main limitation is essentially due to the late gestation week in which diagnosis is performed. The celomic cavity develops around 4 weeks of pregnancy within the extraembryonic mesoderm and contains embryonic erythroid precursor cells as a source of fetal DNA that can be used to perform invasive prenatal diagnosis.MethodsCelomatic fluids were obtained at 8 weeks of gestation in thirteen women with high‐risk pregnancies. Twelve of these couples were at risk for Hb Lepore disease and β‐thalassemia and one couple represented a rare case in which both parents were carriers of Hb Lepore Boston‐Washington. Fetal cells were isolated by micromanipulator and nested polymerase chain reactions were performed.ResultsThe analysis was successfully performed in all examined cases. Two fetuses were found to have a compound heterozygosity for β‐thalassemia and Hb Lepore Boston‐Washington, three fetuses were found to be carriers of β‐thalassemia, three fetuses of Hb Lepore, five were found without parental mutations. The genotypic analysis, carried out both by amniocentesis and on abortive tissue or after birth, showed concordance with results obtained on fetal celomic DNA.ConclusionOur results unequivocally show that fetal DNA can be obtained by nucleated fetal cells present in celomatic fluid and demonstrate for the first time that prenatal diagnosis of β‐thalassemia and Hb Lepore may be feasible in an earlier time of pregnancy than other procedures.
Does the monetary policy regime matter in the effect of credit on growth?
Authors: Altuzarra Amaia , Bustillo Ricardo , Rodríguez Carlos 
Published: March 2022

AbstractThis study sheds light on the finance–growth link by (i) carefully taking into account the lessons learned from the empirical literature, (ii) extending the period of analysis to include the years following the global financial crisis (GFC), (iii) adding the monetary‐policy regime as a concomitant factor in this relation, and (iv) running different specifications and following a robust econometric approach. We find that the positive effect of finance via credit vanishes between the end of the 1990s and the beginning of the 2000s, coinciding with most countries reaching a high level of bank credit and with the GFC. This finding is also observed if an inverted U‐shaped specification is used to capture the relation between finance and growth. As for the monetary‐policy regime, the results reveal that the inflation‐targeting strategy does not exert a positive influence on economic growth.
Young migrants and their transition to adulthood: A case study of Bhutan's Wangdue and Punakha districts
Authors: Dorji Kinley , Tshewang Sonam , Lakey Lakey , Tenzin Jigme 
Published: March 2022

AbstractThis study seeks to understand the transition of youthful rural migrants to urban areas of Bhutan. The goal is to help frame better policy guidelines and efficient intervention strategies. A majority of these migrants are school dropouts with socio‐economic problems who primarily left in search of a better life, despite having arable land to farm back in their home villages. Their urban earnings failed to cover their daily household expenses and other needs, thus affecting the kind and quality of life in an urban setting. Not enough support for migrant youth exists during such critical and vulnerable transition stages when they face the huge responsibilities of independent living early on in their lives. The future for these young migrants remains bleak in the absence of a clear‐cut protective social support and an efficient intervention system.
Depth and latitudinal gradients of diversity in seamount benthic communities
Authors: Bridges Amelia E. H. , Barnes David K. A. , Bell James B. , Ross Rebecca E. , Howell Kerry L. 
Published: March 2022

AbstractAimLatitudinal and bathymetric species diversity gradients in the deep sea have been identified, but studies have rarely considered these gradients across hard substratum habitats, such as seamount and oceanic island margins. This study aimed to identify whether the current understanding of latitudinal and bathymetric gradients in α‐diversity (species richness) apply to seamount ecosystems, as well as ascertaining whether identifiable trends were present in seamount β‐diversity along a bathymetric gradient.LocationExclusive Economic Zones of Saint Helena, Ascension Island and Tristan da Cunha, spanning 8–40°S in the South Atlantic.TaxonSeamount megabenthic communities.MethodsImages from 39 transects, collected between 250 and 950 m, were used to characterise species richness. We subsequently applied general linear models to test possible environmental drivers across latitudinal and bathymetric ranges. Regression models were employed to investigate the β‐diversity gradient of species turnover with depth.ResultsTransects in temperate latitude had significantly higher species richness than those in the tropics. Surface primary productivity and substrate hardness both had significant positive effects on species richness, and a weak relationship between temperature and species richness was observed. No significant relationship between species richness and depth was detected, but there was significant species turnover with depth.Main conclusionsSeamounts and oceanic islands do not conform to established depth–diversity relationships within the depth range studied. However, seamounts and oceanic islands in the South Atlantic do appear to follow a parabolic latitudinal diversity gradient, closely associated with higher productivity in temperate regions.
Repetitive extragenic palindromic and enterobacterial repetitive intergenic consensus sequence‐based typing of Shiga toxin‐producing Escherichia coli from bovine samples
Authors: Joseph Jomy , Sankarshanan Mohan , Kalyanikutty Sudha 
Published: March 2022

AbstractThe strain typing of Shiga toxin‐producing Escherichia coli (STEC) is challenging due to its high genetic variability. In the present study, two polymerase chain reaction (PCR)‐based typing methods—repetitive extragenic palindromic sequences PCR (REP‐PCR) and enterobacterial repetitive intergenic consensus sequences PCR (ERIC‐PCR)—are evaluated for their efficacy in differentiating the strains. The present study used 100 strains of STEC isolated from bovine meat, bovine feces, and swabs from the chopping boards. The REP‐PCR profiles showed 21 different banding patterns, whereas ERIC‐PCR profiles obtained 18 patterns among the tested strains. The dendrogram prepared by the neighbor‐joining method formed eight and seven clusters for REP and ERIC‐PCR, respectively. The discriminatory indices for the typing methods were 87.83 and 83.03% for REP and ERIC‐PCR, respectively. Thus, the clusters based on REP and ERIC‐PCR fingerprints were unambiguous and thus could be useful for phylogenetic clustering and epidemiological surveillance. The nonparametric multidimensional scaling plots showed more than 75 and 60% similarities within populations of different REP and ERIC clusters, respectively, regarding its source of isolation, serogroup, and distribution virulence markers. The REP and the ERIC sequences are good molecular markers that offer rapid, cost‐effective, and easy molecular typing for STEC strains.
The effects of exposure to others' ideas and their ratings on online crowdsourcing platforms on the quantity and novelty of subsequently generated ideas
Authors: Chen Bo , Althuizen Niek 
Published: March 2022

AbstractResearch has shown that exposing people to others' ideas and the ratings of those ideas can influence their subsequent idea generation performance. In this paper, we utilize a socio‐cognitive perspective to study this in an online crowdsourcing context. The cognitive factor concerns knowledge activated in memory because of idea exposure, which can be used for subsequent idea generation. The social factor concerns idea ratings that may steer the search for ideas in memory in the direction of ideas that are more likely to receive approval. Our contribution to the literature concerns an investigation of the joint effect of (1) the type of ideas posted by others (i.e., common versus novel ideas) and (2) the ratings of those ideas (i.e., low versus high ratings) on subsequent idea generation performance. We find compelling evidence for an interaction effect between these two factors in four empirical studies. That is, exposure to posted ideas that are “highly‐ratedandnovel” or “poorly‐ratedandcommon” can result in more novel subsequent ideas. Exposure to posted ideas that are “highly‐ratedandcommon” can result in a larger number of subsequent ideas. These findings have implications for product innovation managers who wish to exert more control over the number and type of generated ideas, for example, on online crowdsourcing platforms.
Implementation of remote support services: Pre‐COVID‐19
Authors: Wagner Jordan B. , Tassé Marc J. , Ornan Gili 
Published: March 2022

AbstractIn this national survey of departments of developmental disabilities services across the United States, we attempted to establish the number of the states that made remote support services available as an authorized service in some state Medicaid funded developmental disabilities waiver programs. Remote support services were defined as a service that uses technology to support an individual with developmental disabilities and is provided from a location outside of the person's home. Remote support services involve the use of technology to provide real‐time assistance from a direct support professional from a remote location. We found that 18 of the 49 states (37%) that responded to our telephone survey reported offering some form of remote support services. This survey was conducted pre‐COVID‐19 and the implications of the availability of remote support services are discussed especially in light of COVID‐19.
Neutral and outlier single nucleotide polymorphisms disentangle the evolutionary history of a coastal Solanaceae species
Authors: Guzmán Sebastián , Giudicelli Giovanna C. , Turchetto Caroline , Bombarely Aureliano , Freitas Loreta B. 
Published: March 2022

AbstractSpeciation begins with the isolation of some individuals or subpopulations due to drivers promoting a diverging genetic distribution. Such isolation may occur, followed by different processes and pressures. Isolation‐by‐distance (IBD), isolation‐by‐adaptation (IBA), and isolation‐by‐colonization (IBC) have been recognized as the main divergence patterns. Still, it is not easy to distinguish which one is the main pattern as each one may act at different points in time or even simultaneously. Using an extensive genome coverage from a Petunia species complex with coastal and inland distribution and multiple analytical approaches on population genomics and phylogeography, we showed a complex interplay between neutral and selective forces acting on the divergence process. We found 18,887 SNPs potentially neutral and 924 potentially under selection (outlier) loci. All analyses pointed that each subspecies displays its own genetic component and evolutionary history. We suggested plausible ecological drivers for such divergence in a southernmost South Atlantic coastal plain in Brazil and Uruguay and identified a connection between adaptation and environment heterogeneity.