bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast prototype selection algorithm based on adjacent neighbourhood and boundary approximation
Authors: Li Juan , Dai Cai 
Published: November 2022

AbstractThe unceasing increase of data quantity severely limits the wide application of mature classification algorithms due to the unacceptable execution time and the insufficient memory. How to fast incrementally obtain high decision reference set and adapt to incremental data environment is urgently needed in incremental environments, large dataset, etc. This paper proposes a novel prototype selection algorithm by integrating the strategies between condensing method and editing method. To an unlearned pattern, this algorithm extends the references scope from its single nearest neighbour to its k nearest neighbourhood that can expand the judgment information to obtain its detailed neighbour relationship. Then a pattern was determined whether it is a prototype using its neighbour relationship and classification boundary asymptotically strategy. To maintain the higher reference set, this algorithm periodically updates those prototypes that locates in the non-boundary zone or is long-time unlearned. The empirical study shows that this algorithm obtains the smaller and higher boundary prototypes without decreasing classification accuracy and reduction rate than the compared algorithms.
An RCT study showing few weeks of music lessons enhance audio-visual temporal processing
Authors: Che Yuqing , Jicol Crescent , Ashwin Chris , Petrini Karin 
Published: November 2022

AbstractMusic involves different senses and is emotional in nature, and musicians show enhanced detection of audio-visual temporal discrepancies and emotion recognition compared to non-musicians. However, whether musical training produces these enhanced abilities or if they are innate within musicians remains unclear. Thirty-one adult participants were randomly assigned to a music training, music listening, or control group who all completed a one-hour session per week for 11 weeks. The music training group received piano training, the music listening group listened to the same music, and the control group did their homework. Measures of audio-visual temporal discrepancy, facial expression recognition, autistic traits, depression, anxiety, stress and mood were completed and compared from the beginning to end of training. ANOVA results revealed that only the music training group showed a significant improvement in detection of audio-visual temporal discrepancies compared to the other groups for both stimuli (flash-beep and face-voice). However, music training did not improve emotion recognition from facial expressions compared to the control group, while it did reduce the levels of depression, stress and anxiety compared to baseline. This RCT study provides the first evidence of a causal effect of music training on improved audio-visual perception that goes beyond the music domain.
Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality
Authors: Madè Alisia , Greco Simona , Vausort Melanie , Miliotis Marios , Schordan Eric , Baksi Shounak , Zhang Lu , Baryshnikova Ekaterina , Ranucci Marco , Cardani Rosanna , Fagherazzi Guy , Ollert Markus , Tastsoglou Spyros , Vatsellas Giannis , Hatzigeorgiou Artemis , Firat Hüseyin , Devaux Yvan , Martelli Fabio 
Published: November 2022

AbstractCoronavirus disease-2019 (COVID-19) can be asymptomatic or lead to a wide symptom spectrum, including multi-organ damage and death. Here, we explored the potential of microRNAs in delineating patient condition and predicting clinical outcome. Plasma microRNA profiling of hospitalized COVID-19 patients showed that miR-144-3p was dynamically regulated in response to COVID-19. Thus, we further investigated the biomarker potential of miR-144-3p measured at admission in 179 COVID-19 patients and 29 healthy controls recruited in three centers. In hospitalized patients, circulating miR-144-3p levels discriminated between non-critical and critical illness (AUCmiR-144-3p = 0.71; p = 0.0006), acting also as mortality predictor (AUCmiR-144-3p = 0.67; p = 0.004). In non-hospitalized patients, plasma miR-144-3p levels discriminated mild from moderate disease (AUCmiR-144-3p = 0.67; p = 0.03). Uncontrolled release of pro-inflammatory cytokines can lead to clinical deterioration. Thus, we explored the added value of a miR-144/cytokine combined analysis in the assessment of hospitalized COVID-19 patients. A miR-144-3p/Epidermal Growth Factor (EGF) combined score discriminated between non-critical and critical hospitalized patients (AUCmiR-144-3p/EGF = 0.81; p < 0.0001); moreover, a miR-144-3p/Interleukin-10 (IL-10) score discriminated survivors from nonsurvivors (AUCmiR-144-3p/IL-10 = 0.83; p < 0.0001). In conclusion, circulating miR-144-3p, possibly in combination with IL-10 or EGF, emerges as a noninvasive tool for early risk-based stratification and mortality prediction in COVID-19.
Stroboscopic thermally-driven mechanical motion
Authors: Ornigotti Luca , Filip Radim 
Published: November 2022

AbstractUnstable nonlinear systems can produce a large displacement driven by a small thermal initial noise. Such inherently nonlinear phenomena are stimulating in stochastic physics, thermodynamics, and in the future even in quantum physics. In one-dimensional mechanical instabilities, recently made available in optical levitation, the rapidly increasing noise accompanying the unstable motion reduces a displacement signal already in its detection. It limits the signal-to-noise ratio for upcoming experiments, thus constraining the observation of such essential nonlinear phenomena and their further exploitation. An extension to a two-dimensional unstable dynamics helps to separate the desired displacement from the noisy nonlinear driver to two independent variables. It overcomes the limitation upon observability, thus enabling further exploitation. However, the nonlinear driver remains unstable and rapidly gets noisy. It calls for a challenging high-order potential to confine the driver dynamics and rectify the noise. Instead, we propose and analyse a feasible stroboscopically-cooled driver that provides the desired detectable motion with sufficiently high signal-to-noise ratio. Fast and deep cooling, together with a rapid change of the driver stiffness, are required to reach it. However, they have recently become available in levitating optomechanics. Therefore, our analysis finally opens the road to experimental investigation of thermally-driven motion in nonlinear systems, its thermodynamical analysis, and future quantum extensions.
Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment
Authors: Sato Hiroaki , Noma Kazuhiro , Ohara Toshiaki , Kawasaki Kento , Akai Masaaki , Kobayashi Teruki , Nishiwaki Noriyuki , Narusaka Toru , Komoto Satoshi , Kashima Hajime , Katsura Yuki , Kato Takuya , Kikuchi Satoru , Tazawa Hiroshi , Kagawa Shunsuke , Shirakawa Yasuhiro , Kobayashi Hisataka , Fujiwara Toshiyoshi 
Published: November 2022

AbstractCancer-associated fibroblasts (CAFs) play a significant role in tumor progression within the tumor microenvironment. Previously, we used near-infrared photoimmunotherapy (NIR-PIT), a next-generation cancer cell-targeted phototherapy, to establish CAF-targeted NIR-PIT. In this study, we investigated whether dual-targeted NIR-PIT, targeting cancer cells and CAFs, could be a therapeutic strategy. A total of 132 cases of esophageal cancer were analyzed for epidermal growth factor receptor (EGFR), human epidermal growth factor 2 (HER2), and fibroblast activation protein (FAP) expression using immunohistochemistry. Human esophageal cancer cells and CAFs were co-cultured and treated with single- or dual-targeted NIR-PIT in vitro. These cells were co-inoculated into BALB/c-nu/nu mice and the tumors were treated with single-targeted NIR-PIT or dual-targeted NIR-PIT in vivo. Survival analysis showed FAP- or EGFR-high patients had worse survival than patients with low expression of FAP or EGFR (log-rank, P < 0.001 and P = 0.074, respectively), while no difference was observed in HER2 status. In vitro, dual (EGFR/FAP)-targeted NIR-PIT induced specific therapeutic effects in cancer cells and CAFs along with suppressing tumor growth in vivo, whereas single-targeted NIR-PIT did not show any significance. Moreover, these experiments demonstrated that dual-targeted NIR-PIT could treat cancer cells and CAFs simultaneously with a single NIR light irradiation. We demonstrated the relationship between EGFR/FAP expression and prognosis of patients with esophageal cancer and the stronger therapeutic effect of dual-targeted NIR-PIT than single-targeted NIR-PIT in experimental models. Thus, dual-targeted NIR-PIT might be a promising therapeutic strategy for cancer treatment.
Quality measures for fully automatic CT histogram-based fat estimation on a corpse sample
Authors: Schenkl Sebastian , Hubig Michael , Muggenthaler Holger , Shanmugam Jayant Subramaniam , Güttler Felix , Heinrich Andreas , Teichgräber Ulf , Mall Gita 
Published: November 2022

AbstractIn a previous article a new algorithm for fully automatic ‘CT histogram based Fat Estimation and quasi-Segmentation’ (CFES) was validated on synthetic data, on a special CT phantom, and tested on one corpse. Usage of said data in FE-modelling for temperature-based death time estimation is the investigation’s number one long-term goal. The article presents CFES’s results on a human corpse sample of size R = 32, evaluating three different performance measures: the τ-value, measuring the ability to differentiate fat from muscle, the anatomical fat-muscle misclassification rate D, and the weighted distance S between the empirical and the theoretical grey-scale value histogram. CFES-performance on the sample was: D = 3.6% for weight exponent α = 1, slightly higher for α ≥ 2 and much higher for α ≤ 0. Investigating τ, S and D on the sample revealed some unexpected results: While large values of τ imply small D-values, rising S implies falling D and there is a positive linear relationship between τ and S. The latter two findings seem to be counter-intuitive. Our Monte Carlo analysis detected a general umbrella type relation between τ and S, which seems to stem from a pivotal problem in fitting Normal mixture distributions.
Association between CYP2E1 polymorphisms and colorectal cancer risk: a systematic review and meta-analysis
Authors: Sharzehan Mohamad Ayub Khan , Sito Hilary , Abdullah Noraidatulakma , Alexiou Athanasios , Papadakis Marios , Jamal Rahman , Tan Shing Cheng 
Published: November 2022

AbstractCYP2E1 encodes an enzyme that participates in the activation of several carcinogenic substances. Thus, numerous studies have investigated the association between CYP2E1 polymorphisms and colorectal cancer (CRC) risk, but inconclusive results have been obtained. We performed a meta-analysis to precisely evaluate the relationship of CYP2E1 rs2031920, rs3813867, and rs6413432 polymorphisms with the susceptibility to CRC. Scopus, Web of Science and PubMed databases were searched to identify eligible studies, and the association between the polymorphisms and CRC risk was then quantitatively synthesized using different genetic models. Eighteen studies with 23,598 subjects were selected for inclusion into the analysis. Significant association between rs2031920 and an increased CRC risk was observed in homozygous (OR = 1.496, 95% CI 1.177–1.901, P = 0.001), recessive (OR = 1.467, 95% CI  1.160–1.857, P = 0.001) and allele (OR = 1.162, 95% CI  1.001–1.349, P = 0.048) models. Significant association was not found for rs3813867 and rs6413432 (P > 0.05). In conclusion, our results suggest that rs2031920, but not rs3813867 and rs6413432, is associated with the risk of CRC.
Identification of a key ceRNA network associated with ferroptosis in gastric cancer
Authors: Jin Wen , Liu Jianli , Yang Jie , Feng Zongqi , Feng Zhenxing , Huang Na , Yang Tingyu , Yu Lan 
Published: November 2022

AbstractFerroptosis, a newly discovered irondependent form of regulated cell death caused by excessive accumulation of lipid peroxides, is linked to the development and treatment response of various types of cancer, including gastric cancer (GC). Noncoding RNAs (ncRNAs), as key regulators in cancer, have both oncogenic and tumor suppressive roles. However, studies on ferroptosis-related ncRNA networks in GC are still lacking. Here, we first identified 61 differentially expressed genes associated with ferroptosis in GC by computing and analyzing gene expression profile of tumor and normal tissues for GC. Then, upstream lncRNAs and miRNAs interacting with them were found through miRNet and miRBase databases, and hub lncRNAs and miRNAs were obtained through topological analysis. Finally, the ceRNA regulatory network linked to ferroptosis in GC was established, which includes two ferroptosis marker genes (TXNIP and TSC22D3), one driver gene (GABARAPL1), and one suppressor gene (CAV1). Kaplan-Meier survival analysis showed that changes in the expression of these genes were associated with the survival of GC patients. Furthermore, our study revealed that this ceRNA network may influence the progression of GC by regulating ferroptosis process. These results will help experimental researchers to design an experiment study to further explore the roles of this regulatory network in GC ferroptosis.
Stimulus decay functions in action control
Authors: Frings Christian , Moeller Birte , Beste Christian , Münchau Alexander , Pastötter Bernhard 
Published: November 2022

AbstractWhen facing particular combinations of stimuli and responses, people create temporary event-files integrating the corresponding stimulus and response features. Subsequent repetition of one or more of these features retrieves the entire event-file, which impairs performance if not all features are repeated (partial-repetition costs). In the literature, different decay functions have been reported presumably dependent on the type of feature that is repeated (e.g. target vs. distractor features). Here, we use a variant of the S1R1-S2R2 and distractor-response binding task and analyze for the first time target-based and distractor-based event-file decay functions within the same task and sample. While we found evidence for decay functions and also stronger retrieval due to target than distractor repetitions, slopes of the decay functions were comparable suggesting that the decay process itself is equal irrespective of the type of stimulus feature that is repeated. Our study thereby confirms overarching approaches that summarize paradigm specific findings with the same set of core processes.
Genetic trends in CIMMYT’s tropical maize breeding pipelines
Authors: Prasanna Boddupalli M. , Burgueño Juan , Beyene Yoseph , Makumbi Dan , Asea Godfrey , Woyengo Vincent , Tarekegne Amsal , Magorokosho Cosmos , Wegary Dagne , Ndhlela Thokozile , Zaman-Allah Mainassara , Matova Prince M. , Mwansa Kabamba , Mashingaidze Kingstone , Fato Pedro , Teklewold Adefris , Vivek B. S. , Zaidi P. H. , Vinayan M. T. , Patne Nagesh , Rakshit Sujay , Kumar Ramesh , Jat S. L. , Singh S. B. , Kuchanur Prakash H. , Lohithaswa H. C. , Singh N. K. , Koirala K. B. , Ahmed Salahuddin , Vicente Felix San , Dhliwayo Thanda , Cairns Jill E. 
Published: November 2022

AbstractFostering a culture of continuous improvement through regular monitoring of genetic trends in breeding pipelines is essential to improve efficiency and increase accountability. This is the first global study to estimate genetic trends across the International Maize and Wheat Improvement Center (CIMMYT) tropical maize breeding pipelines in eastern and southern Africa (ESA), South Asia, and Latin America over the past decade. Data from a total of 4152 advanced breeding trials and 34,813 entries, conducted at 1331 locations in 28 countries globally, were used for this study. Genetic trends for grain yield reached up to 138 kg ha−1 yr−1 in ESA, 118 kg ha−1 yr−1 South Asia and 143 kg ha−1 yr−1 in Latin America. Genetic trend was, in part, related to the extent of deployment of new breeding tools in each pipeline, strength of an extensive phenotyping network, and funding stability. Over the past decade, CIMMYT’s breeding pipelines have significantly evolved, incorporating new tools/technologies to increase selection accuracy and intensity, while reducing cycle time. The first pipeline, Eastern Africa Product Profile 1a (EA-PP1a), to implement marker-assisted forward-breeding for resistance to key diseases, coupled with rapid-cycle genomic selection for drought, recorded a genetic trend of 2.46% per year highlighting the potential for deploying new tools/technologies to increase genetic gain.
Intracrystalline deformation microstructures in natural olivine with implications for stress estimation
Authors: Ma Jian , Liu Wenlong , Cao Yi , Zhang Junfeng , Liu Chuanzhou 
Published: November 2022

AbstractConstraining the stress related to lithospheric deformation in natural rocks is key to develop and test a geodynamic model. However, the cautions of extrapolating piezometers that are established on experimental samples to natural rocks are less addressed. In this study, we investigated the microstructures of a natural harzburgite sample using the electron backscatter diffraction (EBSD) technique. Subgrain boundary (SGB) geometries suggest large percentages of (010)[100] and {0kl}[100] dislocation slip systems in olivines. More importantly, multiple low-angle misorientation boundaries (LAMBs) variants are recognized for the first time in olivine based on their distinctive characteristics with the change of EBSD mapping step size. The LAMBs that exist at a small step size (≤ 1 μm) are mostly equivalent to real SGBs, while other LAMBs that appear only when the step size is larger (> 1 μm) are artificial SGBs. Besides, the former develop mainly in the high LAMB density grains, whereas the latter are mostly found in the low LAMB density grains. This result reinforces the previous knowledge that the stress calculated using subgrain-related piezometers is meaningful only when real SGBs are captured at sufficiently small step size. Furthermore, we provide a proof of concept that SGB density and kernel average misorientation (KAM) are two viable metrics to estimate stress. These two alternative piezometers, which still need calibrations using the experimentally deformed samples, are anticipated to have wide applications in natural rocks.
The Hubble constant troubled by dark matter in non-standard cosmologies
Authors: Alcaniz J. S. , Neto J. P. , Queiroz F. S. , da Silva D. R. , Silva R. 
Published: November 2022

AbstractThe Standard Cosmological Model has experienced tremendous success at reproducing observational data by assuming a universe dominated by a cosmological constant and dark matter in a flat geometry. However, several studies, based on local measurements, indicate that the universe is expanding too fast, in disagreement with the Cosmic Microwave Background. Taking into account combined data from CMB, Baryon Acoustic Oscillation, and type Ia Supernovae, we show that if the mechanism behind the production of dark matter particles has at least a small non-thermal origin, one can induce larger values of the Hubble rate$$H_0$$H0, within the$$\Lambda$$ΛCDM, to alleviate the trouble with$$H_0$$H0. In the presence of non-standard cosmology, however, we can fully reconcile CMB and local measurements and reach$$H_0=70$$H0=70–74 $${\text {km s}}^{-1}\,{\text {Mpc}}^{-1}$$km s-1Mpc-1.
The autism-associated Meis2 gene is necessary for cardiac baroreflex regulation in mice
Authors: Roussel J. , Larcher R. , Sicard P. , Bideaux P. , Richard S. , Marmigère F. , Thireau J. 
Published: November 2022

AbstractRecent understanding of Autism Spectrum Disorder (ASD) showed that peripheral primary mechanosensitive neurons involved in touch sensation and central neurons affected in ASD share transcriptional regulators. Mutant mice for ASD-associated transcription factors exhibit impaired primary tactile perception and restoring those genes specifically in primary sensory neurons rescues some of the anxiety-like behavior and social interaction defects. Interestingly, peripheral mechanosensitive sensory neurons also project to internal organs including the cardiovascular system, and an imbalance of the cardio-vascular sympathovagal regulation is evidenced in ASD and intellectual disability. ASD patients have decreased vagal tone, suggesting dysfunction of sensory neurons involved in cardio-vascular sensing. In light of our previous finding that the ASD-associated Meis2 gene is necessary for normal touch neuron development and function, we investigated here if its inactivation in mouse peripheral sensory neurons also affects cardio-vascular sympathovagal regulation and baroreflex. Combining echocardiography, pharmacological challenge, blood pressure monitoring, and heart rate variability analysis, we found that Meis2 mutant mice exhibited a blunted vagal response independently of any apparent cardiac malformation. These results suggest that defects in primary sensory neurons with mechanosensitive identity could participate in the imbalanced cardio-vascular sympathovagal tone found in ASD patients, reinforcing current hypotheses on the role of primary sensory neurons in the etiology of ASD.
Optimized APPS-tDCS electrode position, size, and distance doubles the on-target stimulation magnitude in 3000 electric field models
Authors: Caulfield Kevin A. , George Mark S. 
Published: November 2022

AbstractTranscranial direct current stimulation (tDCS) is a widely used noninvasive brain stimulation technique with mixed results to date. A potential solution is to apply more efficient stimulation to ensure that each participant receives sufficient cortical activation. In this four-part study, we used electric field (E-field) modeling to systematically investigate the cortical effects of conventional and novel tDCS electrode montages, with the goal of creating a new easily adoptable form of tDCS that induces higher and more focal E-fields. We computed 3000 anatomically accurate, MRI-based E-field models using 2 mA tDCS to target the left primary motor cortex in 200 Human Connectome Project (HCP) participants and tested the effects of: 1. Novel Electrode Position, 2. Electrode Size, and 3. Inter-Electrode Distance on E-field magnitude and focality. In particular, we examined the effects of placing electrodes surrounding the corticomotor target in the anterior and posterior direction (anterior posterior pad surround tDCS; APPS-tDCS). We found that electrode position, electrode size, and inter-electrode distance all significantly impact the cortical E-field magnitude and focality of stimulation (all p < 0.0001). At the same 2 mA scalp stimulation intensity, APPS-tDCS with smaller than conventional 1 × 1 cm electrodes surrounding the neural target deliver more than double the on-target cortical E-field (APPS-tDCS: average of 0.55 V/m from 2 mA; M1-SO and bilateral M1: both 0.27 V/m from 2 mA) while stimulating only a fraction of the off-target brain regions; 2 mA optimized APPS-tDCS produces 4.08 mA-like cortical E-fields. In sum, this new optimized APPS-tDCS method produces much stronger cortical stimulation intensities at the same 2 mA scalp intensity. APPS-tDCS also more focally stimulates the cortex at the intended target, using simple EEG coordinate locations and without MRI scans. This APPS-tDCS method is adoptable to any existing, commercially available tDCS device and can be used to ensure sufficient cortical activation in each person. Future directions include testing whether APPS-tDCS produces larger and more consistent therapeutic tDCS effects.