bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early detection of Alzheimer’s disease using neuropsychological tests: a predict–diagnose approach using neural networks
Authors: Mukherji Devarshi , Mukherji Manibrata , Mukherji Nivedita ,   Alzheimer’s Disease Neuroimaging Initiative
Published: September 2022

AbstractAlzheimer’s disease (AD) is a slowly progressing disease for which there is no known therapeutic cure at present. Ongoing research around the world is actively engaged in the quest for identifying markers that can help predict the future cognitive state of individuals so that measures can be taken to prevent the onset or arrest the progression of the disease. Researchers are interested in both biological and neuropsychological markers that can serve as good predictors of the future cognitive state of individuals. The goal of this study is to identify non-invasive, inexpensive markers and develop neural network models that learn the relationship between those markers and the future cognitive state. To that end, we use the renowned Alzheimer’s Disease Neuroimaging Initiative (ADNI) data for a handful of neuropsychological tests to train Recurrent Neural Network (RNN) models to predict future neuropsychological test results and Multi-Level Perceptron (MLP) models to diagnose the future cognitive states of trial participants based on those predicted results. The results demonstrate that the predicted cognitive states match the actual cognitive states of ADNI test subjects with a high level of accuracy. Therefore, this novel two-step technique can serve as an effective tool for the prediction of Alzheimer’s disease progression. The reliance of the results on inexpensive, non-invasive tests implies that this technique can be used in countries around the world including those with limited financial resources.
MicroRNA miR-627-5p restrains pulmonary artery smooth muscle cell dysfunction by targeting MAP 2 K4 and PI3K/AKT signaling
Authors: Li Ting , Tan Xiaoqin , Huang Yuexia , Cui Jun , Chen Fan , Xiong Ying 
Published: September 2022

Abstract
Background
Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary vascular remodeling, which can be caused by abnormal proliferation and migration of pulmonary artery smooth muscle cells (PASMCs). Several microRNAs were demonstrated to regulate the PASMC dysfunction. Our study intends to evaluate whether miR-627-5p affects cigarette smoke extract (CSE)-induced aberrant biological behaviors of PASMCs.

Methods
PASMCs was treated with CSE to create the in vitro cellular model of COPD. The viability and LDH release of PASMCs was detected by CCK-8 assay and LDH release assay. MiR-627-5p and MAP 2 K4 expression in CSE (2%)-treated PASMCs was detected by qRT-PCR. PASMC proliferation was observed under a microscope, and PASMC migration was assessed by Transwell migration assays. The binding of miR-627-5p on MAP 2 K4 was verified by dual-luciferase reporter assay. Protein levels of MAP2K4 and the PI3K/AKT signaling markers were examined by western blotting.

Results
The viability of PASMCs treated with 2% CSE reached a peak. CSE dose-dependently downregulated miR-627-5p expression in PASMCs. MiR-627-5p overexpression attenuated the CSE-induced abnormal proliferation and migration of PASMCs. However, MAP2K4 overexpression antagonized the effects of miR-627-5p on PASMC dysfunction. Importantly, miR-627-5p inhibited CSE-stimulated activation of the PI3K/AKT pathway via downregulating MAP2K4.

Conclusion
MiR-627-5p improves CSE-induced abnormal proliferation and migration of PASMCs by inhibiting MAP2K4 expression and the PI3K/AKT pathway.
How university teachers navigate social networking sites in a fully online space: provisional views from a developing nation
Authors: Barrot Jessie S. , Acomular Denson R. 
Published: September 2022

AbstractAlthough social networking sites (SNS) have been widely investigated, very limited information is available about how teachers navigate them within a fully online learning space, the challenges they confront, and the strategies they use to overcome them. Thus, we examined these underexplored areas by interviewing 14 higher education teachers in the field of social sciences. Using a cross-case analysis, overall data indicates that teachers had varied reasons for and considered different factors when adopting SNS for online teaching. Our study also reveals that they used SNS affordances depending on their own teaching contexts and took different roles when teaching online via this platform. Although teachers generally viewed SNS as an instructional approach, they also reported several technical, pedagogical, and learner-related challenges, which they attempted to confront using a variety of strategies. These findings confirmed that teachers’ pedagogical practices and decisions in an SNS-mediated learning environment are shaped by the interaction between and among the teacher-related factors, SNS as an instructional tool, and teaching goals mediated by the policies (existing or not) and their peers. Some key implications of our findings are on designing teacher development programs, recalibrating national, institutional, and classroom policies, and implementing a systemic approach to mitigating pedagogical challenges in an online learning space. Implications for future studies are also discussed.
From Elif to Esty? Unorthodox and Turkish German Cinema's Captivity Narrative
Authors: Landry Olivia 
Published: September 2022

Abstract
The 2020 Netflix drama series Unorthodox draws on tropes from a vexed archive of transcultural cinema, in particular Turkish German cinema. Through the frame of the captivity narrative, this essay examines how the series about a young Hasidic Jewish woman who escapes her family and community in Williamsburg, New York, and flees to Berlin presents culturally determined themes of victimhood, oppression, and gendered subjugation. A comparison with Turkish German films, such as 40 Square Meters of Germany (40 Quadratmeter Deutschland, dir. Tevfik Başer, West Germany, 1986) and When We Leave (Die Fremde, dir. Feo Aladağ, Germany, 2010), calls attention to the continuity of the captivity narrative, with its troubling themes, and asks the question of intent. As scholars have indicated in the case of Turkish German cinema, filmmakers have frequently been faced with the task of appealing to German mainstream audiences eager to see their own cultural stereotypes reaffirmed on screen. Rooted in colonialist and Orientalist fantasies, the captivity narrative provided an effective conduit. But what is it still doing in Unorthodox? Close readings of several scenes from the series and engagement with Hortense Spillers's concept of “pornotroping” as well as Hamid Naficy's “housebondage” and Meyda Yeğenoğlu's “unveiling” reveal at once the problems and the possibilities of Unorthodox as it employs and subverts the captivity narrative. The essay concludes with an analysis of place, namely, the Berlin setting of the series, as a historically fraught context that likewise raises questions about intentionality and the role of Germany's past and present.
Robust Adaptive Submodular Maximization
Authors: Tang Shaojie 
Published: September 2022

The goal of a sequential decision-making problem is to design an interactive policy that adaptively selects a group of items, each selection is based on the feedback from the past, to maximize the expected utility of selected items. It has been shown that the utility functions of many real-world applications are adaptive submodular. However, most of existing studies on adaptive submodular optimization focus on the average-case, that is, their objective is to find a policy that maximizes the expected utility over a known distribution of realizations. Unfortunately, a policy that has a good average-case performance may have very poor performance under the worst-case realization. In this study, we propose to study two variants of adaptive submodular optimization problems, namely, worst-case adaptive submodular maximization and robust submodular maximization. The first problem aims to find a policy that maximizes the worst-case utility and the latter one aims to find a policy, if any, that achieves both near optimal average-case utility and worst-case utility simultaneously. We introduce a new class of stochastic functions, called worst-case submodular function. For the worst-case adaptive submodular maximization problem subject to a p-system constraint, we develop an adaptive worst-case greedy policy that achieves a [Formula: see text] approximation ratio against the optimal worst-case utility if the utility function is worst-case submodular. For the robust adaptive submodular maximization problem subject to cardinality constraints (respectively, partition matroid constraints), if the utility function is both worst-case submodular and adaptive submodular, we develop a hybrid adaptive policy that achieves an approximation close to [Formula: see text] (respectively, 1/3) under both worst- and average-case settings simultaneously. We also describe several applications of our theoretical results, including pool-base active learning, stochastic submodular set cover, and adaptive viral marketing. History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms—Discrete. Supplemental Material: The online appendix is available at https://doi.org/10.1287/ijoc.2022.1239 .
A Branch-and-Repair Method for Three-Dimensional Bin Selection and Packing in E-Commerce
Authors: Fontaine Pirmin , Minner Stefan 
Published: September 2022

Selecting a Parcel Type Portfolio to Reduce Unused Space in Transportation Wrongly sized parcels lead to unused space and inefficient transportation. With continuously increasing e-commerce and last-mile delivery volumes, available parcel types at a warehouse can significantly impact unused space that is transported. In “A Branch-and-Repair Method for Three-Dimensional Bin Selection and Packing in E-Commerce,” Fontaine and Minner solve the trade-off between cost of unused space and cost of parcel variety through optimizing the portfolio of available parcel types. To solve large instances with millions of binary decision variables, the authors develop an exact decomposition method that allows for relaxing many binary variables, improves branch-and-check by repairing infeasible solutions, and shows how to avoid solving many subproblems. A case study using real data shows the efficiency of the proposed method and the impact of the portfolio on unused transportation space.
Battling the obesity epidemic with a school-based intervention: Long-term effects of a quasi-experimental study
Authors: Willeboordse M. , Bartelink N. H. M. , van Assema P. , Kremers S. P. J. , Savelberg H. H. C. M. , Hahnraths M. T. H. , Vonk L. , Oosterhoff M. , van Schayck C. P. , Winkens B. , Jansen M. W. J. 
Published: September 2022

Background
School-based health-promoting interventions are increasingly seen as an effective population strategy to improve health and prevent obesity. Evidence on the long-term effectiveness of school-based interventions is scarce. This study investigates the four-year effectiveness of the school-based Healthy Primary School of the Future (HPSF) intervention on children’s body mass index z-score (BMIz), and on the secondary outcomes waist circumference (WC), dietary and physical activity (PA) behaviours.

Methods and findings
This study has a quasi-experimental design with four intervention schools, i.e., two full HPSFs (focus: diet and PA), two partial HPSFs (focus: PA), and four control schools. Primary school children (aged 4–12 years) attending the eight participating schools were invited to enrol in the study between 2015 and 2019. Annual measurements consisted of children’s anthropometry (weight, height and waist circumference), dietary behaviours (child- and parent-reported questionnaires) and PA levels (accelerometers). Between 2015 and 2019, 2236 children enrolled. The average exposure to the school condition was 2·66 (SD 1·33) years, and 900 participants were exposed for the full four years (40·3%). After four years of intervention, both full (estimated intervention effect (B = -0·17 (95%CI -0·27 to -0·08) p = 0·000) and partial HPSF (B = -0·16 (95%CI-0·25 to -0·06) p = 0·001) resulted in significant changes in children’s BMIz compared to control schools. Likewise, WC changed in favour of both full and partial HPSFs. In full HPSFs, almost all dietary behaviours changed significantly in the short term. In the long term, only consumption of water and dairy remained significant compared to control schools. In both partial and full HPSFs, changes in PA behaviours were mostly absent.

Interpretation
This school-based health-promoting intervention is effective in bringing unfavourable changes in body composition to a halt in both the short and long term. It provides policy makers with robust evidence to sustainably implement these interventions in school-based routine.
A protocol for a qualitative study on sex trafficking: Exploring knowledge, attitudes, and practices of physicians, nurses, and social workers in Ontario, Canada
Authors: Jacobson Danielle , Mason Robin , Bruder Rhonelle , Du Mont Janice 
Published: September 2022

Introduction
There has been limited research on sex trafficking in Canada from a health and health care perspective, despite U.S. research which points to health care providers as optimally positioned to identify and help those who have been sex trafficked. We aim to better understand health care providers’ knowledge about, attitudes towards, and care of those who have been sex trafficked in Ontario, Canada.

Methods and analysis
Using a semi-structured interview guide, we will interview physicians, nurses, and social workers working in a health care setting in Ontario until data saturation is reached. An intersectional lens will be applied to the study; analysis will follow the six analytic phases outlined by Braun and Clarke. In the development of this study, we consulted the consolidated criteria for reporting qualitative research (COREQ) with regards to reflexivity and study design. We will continue to consult this checklist as the study progresses and in the writing of our analysis and findings.

Discussion
To our knowledge, this will be the first study of its kind in Canada. The results hold the potential to inform the development of standardized training on sex trafficking for health care providers. Results of the study may be useful in addressing sex trafficking in other jurisdictions.
Peripheral Exudative Hemorrhagic Chorioretinopathy with and without treatment—Clinical and multimodal imaging characteristics and prognosis
Authors: Safir Margarita , Zloto Ofira , Fabian Ido Didi , Moroz Iris , Gaton Dan D. , Vishnevskia-Dai Vicktoria 
Published: September 2022

Purpose
To describe clinical and imaging characteristics of patients with Peripheral Exudative Hemorrhagic Chorioretinopathy (PEHCR), prognosis and treatment response.

Methods
In this retrospective cohort study medical records of patients diagnosed with PEHCR in a tertiary medical center between 2008 and 2018 were reviewed. Collected data included demographics, medical history, ophthalmologic examination and multi-modal imaging including fundus autofluorescence, optical coherence tomography (OCT), ultrasound (US), fluorescein angiography and indocyanine green angiography when available. Bevacizumab treatment results were analyzed when applied.

Results
35 eyes of 32 patients were included, with a female predominance (56.25%) and an average age of 79.0±9.87 years at presentation. Most common OCT and US findings were subretinal mass (68.75%), pigment epithelial detachment (30.00%) and atrophic changes (21.86%). Median follow-up period was 18.00 months (range 0–102). Visual acuity (VA) remained stable (39.29%) or improved (25.00%) in most cases available for follow-up. Treatment with intravitreal bevacizumab induced a statistically significant clinical resolution in 88.89% of eyes available for follow-up (8/9 eyes) (p = 0.02).

Conclusions
PEHCR is presented with high clinical variability and generally good prognosis. This is the first publication demonstrating a statistically significant clinical resolution of disease following intravitreal bevacizumab injections.
Sociodemographic characteristics associated with hepatitis C virus infection in Vietnamese Americans: A cross-sectional analysis of community screening data
Authors: Lee Alice W. , Jacobs Wura , Tran Michelle , Nguyen Becky , Hua Dung N. , Ho John N. , Van Nguyen Thai 
Published: September 2022

BackgroundPrevalence of hepatitis C virus (HCV) infection among Vietnamese Americans is reportedly high. Understanding the profile of those at greater risk of HCV in this ethnic population is a vital step to addressing this high prevalence. We hypothesize that certain sociodemographic characteristics increase the likelihood of having HCV in Vietnamese Americans.MethodsCross-sectional data from 2,497 Vietnamese Americans in Southern California who participated in a series of community hepatitis screening events organized by the Vietnamese American Cancer Foundation (VACF) were analyzed. Serological tests via immunoassays were used to determine whether the participant had hepatitis C antibodies (anti-HCV) to indicate a HCV infection. Sociodemographic characteristics as well as participants’ reasons for screening were collected from questionnaires, and logistic regression models with odds ratios (ORs) and 95% confidence intervals (CIs) were used to quantify their associations with HCV infection.ResultsApproximately 5.8% of the study population was infected with HCV. Older adults and male participants had higher odds of being infected with HCV (e.g. OR = 2.90, 95% CI 1.25–6.76 for ages 70+ versus ages <40; OR = 2.57, 95% CI 1.79–3.69 for male versus female participants) as were those with a family history of HCV infection (OR = 2.74, 95% CI 1.57–4.78). In addition, perceived self-risk as a motivation for screening was significantly associated with HCV infection (OR = 1.88, 95% CI 1.26–2.78).ConclusionsThis study identifies specific subgroups in the Vietnamese American community who would largely benefit from targeted interventions given their higher likelihood of having HCV. These interventions should emphasize improving HCV knowledge and promoting HCV self-risk assessment since awareness of one’s own risk may motivate those likely to be infected to get screened.
Effects of exposure to sexually explicit material on sexually violent behavior among first-year university men in Vietnam
Authors: Bergenfeld Irina , Cheong Yuk Fai , Minh Tran Hung , Trang Quach Thu , Yount Kathryn M. 
Published: September 2022

Background
Adolescence and emerging adulthood represent a period of heightened vulnerability to sexual violence (SV). While some research suggests that exposure to sexually explicit material (SEM) among adolescents and college students is associated with sexually violent behavior, our understanding of this relationship is limited. This study aimed to assess the relationship between prior exposure to several types of SEM and sexually violent behavior in a sample of first-year university men in Vietnam.

Methods and findings
A cohort of 739 first-year male university students completed three survey waves over 14 months, providing information on contact and non-contact sexually violent behavior, exposure to SEM, and other theorized confounders of the SEM-SV relationship. Controlling for these covariates, we estimated the average treatment effect of SEM on contact and non-contact SV using the propensity score method. We also conducted a dose-response analysis for the effect of violent SEM on SV based on frequency-of-exposure classes derived from latent class analysis. The majority of the sample reported exposure to SEM in the prior six months, with 41% of the sample reporting exposure to violent SEM. In propensity-adjusted models, exposure to violent SEM, but not other types, had a small but significant positive effect on contact and non-contact SV. These effects increased for frequent viewers of violent SEM. Models of contact SV showed endogeneity, warranting caution.

Conclusions
Exposure to violent SEM is prevalent among university men in Vietnam and may be contributing to sexually violent behavior. Incorporating media literacy into SV prevention programs to mitigate these potential effects may be warranted.
Healthcare resource utilization in patients with treatment-resistant depression—A Danish national registry study
Authors: Jensen Kristoffer Jarlov , Gronemann Frederikke Hørdam , Ankarfeldt Mikkel Zöllner , Jimenez-Solem Espen , Alulis Sarah , Riise Jesper , Bødker Nikolaj , Osler Merete , Petersen Janne 
Published: September 2022

Objectives
To investigate healthcare resource utilization (HRU) and associated costs by depression severity and year of diagnosis among patients with treatment-resistant depression (TRD) in Denmark.

Methods
Including all adult patients with a first-time hospital contact for major depressive disorder (MDD) in 1996–2015, TRD patients were defined at the second shift in depression treatment (antidepressant medicine or electroconvulsive therapy) and matched 1:2 with non-TRD patients. The risk of utilization and amount of HRU and associated costs including medicine expenses 12 months after the TRD-defining date were reported, comparing TRD patients with non-TRD MDD patients.

Results
Identifying 25,321 TRD-patients matched with 50,638 non-TRD patients, the risk of psychiatric hospitalization following TRD diagnosis was 138.4% (95%-confidence interval: 128.3–149.0) higher for TRD patients than for non-TRD MDD patients. The number of hospital bed days and emergency department (ED) visits were also higher among TRD patients, with no significant difference for somatic HRU. Among patients who incurred healthcare costs, the associated HRU costs for TRD patients were 101.9% (97.5–106.4) higher overall, and 55.2% (50.9–59.6) higher for psychiatric services than those of non-TRD patients. The relative differences in costs for TRD-patients vs non-TRD patients were greater for patients with mild depression and tended to increase over the study period (1996–2015), particularly for acute hospitalizations and ED visits.

Limitations
TRD was defined by prescription patterns besides ECT treatments.

Conclusion
TRD was associated with increased psychiatric-related HRU. Particularly the difference in acute hospitalizations and ED visits between TRD and non-TRD patients increased over the study period.
Undergraduate Student Perceptions of Industry Guest Speakers in the College Classroom
Authors: Jablon-Roberts Sara , McCracken Arienne 
Published: September 2022

The use of guest speakers in college classes is a well-accepted pedagogical practice, but the academic literature has generally been based on instructor or event organizers’ anecdotal reflections about particular experiences. Moreover, research based upon students’ considerations of this practice have been especially sparse. The purpose of this study is to explore student perceptions of guest speakers to determine what value students find in them. One-hundred fourteen students participated in a qualitative survey, answering questions about their prior experiences with and expectations of industry guest speakers. The results showed that 86.1% of respondents who had previously been enrolled in a college class that featured an industry guest speaker visit liked the experience, especially if the guest currently worked in a field related to course content, spoke enthusiastically and honestly, and answered questions. In particular, participants appreciated hearing insider information about the speaker’s day-to-day work life, as well as advice for their own career path. Recommendations are provided to university educators as guidance for improving student experiences and engagement with guest speakers, especially those from the fashion industry.