bluuebunny/crossref_metadata_2025_split huggingface dataset:
Larvicidal potential ofCipadessa bacciferaleaf extract-synthesized zinc nanoparticles against three major mosquito vectors
Authors: Ramkumar Govindaraju , Shivakumar Muthugoundar Subramanian , Alshehri Mohammed Ali , Panneerselvam Chellasamy , Sayed Samy 
Published: August 2022

AbstractMosquitoes are important vectors, which transmit many communicable diseases throughout the world. Synthetic insecticides, such as organophosphate and pyrethroids, are commonly used for their control in the vector control program. Insecticidal compounds from natural sources, notably from plants and synthesized nanoparticles (NPs) are promising tools for managing such vectors. Hence, the study aimed to analyze the insecticidal potentiality of leaf extract ofCipadessa bacciferaand synthesized ZnNPs against three major mosquito vectors. The results recorded from UV-Vis spectroscopy show the peak absorption spectrum at 420 nm. In FTIR, the maximum peak value is 562.85 cm−1assigned to the N–H group (amide group). The EDAX analysis shows a peak around 63.29, which confirms the binding intensity of selenium. In the scanning electron microscopy analysis, the synthesized ZnNPs sizes were ranging from 49.21 to 65.43 nm. The synthesized ZnNPs produced high mortality againstCulex quinquefasciatusLC50= 0.049653 mg·mL−1; LC90= 0.9842 mg·mL−1),Anopheles stephensi(LC50= 0.053421 mg·mL−1and LC90= 0.027761 mg·mL−1), andAedes aegyptiLC50= 0.55214 mg·mL−1and LC90= 0.7456 mg·mL−1). These results suggest that theC. bacciferaleaf extract-mediated biosynthesis of ZnNPs has the potential to be used as an ideal eco-friendly approach toward the control of mosquito vectors at early stages.
Modelling thermal diffusivity of meat during freezing
Authors: Carson James K. , Hoang Duy K. 
Published: August 2022

Abstract
When modelling a thermal process such as freezing, it is convenient to make use of thermal property models based on the food’s composition; however, there does not appear to be any suitable models specifically for thermal diffusivity. In the absence of such models, thermal diffusivity may be determined from models for effective thermal conductivity, specific heat capacity and density as functions of composition, as well as an appropriate ice fraction model. However, the accuracy of the predictions is strongly dependent on the choice of effective thermal property models. In particular, the effective specific heat capacity model must incorporate the effect of latent heat release as a function of temperature. For meat during freezing, it is recommended that the Dul’Nev Novikov effective thermal conductivity model, Pham’s ice fraction model and Chen’s effective heat capacity model are used.
Dielectric properties of honey adulterated by sugar syrup
Authors: Baxi Vikrant K. , Gadani Deepak H. , Rana Vipin A. 
Published: August 2022

Abstract
Dielectric properties of pure honey adulterated by varying amount of sugar syrup have been measured over 20 Hz to 2 MHz frequency range, at room temperature. The samples were prepared by mixing different proportions of sugar syrup in pure honey. It has been observed that, dielectric constant (ε′) and dielectric loss (ε″) of the mixture increases as percentage of sugar-syrup in honey increases. ε′ of the mixture decreases rapidly with the increase in frequency and achieves static value at higher frequency. ε″ decreases linearly with increase in frequency. The relaxation time corresponding to tanδ peak varies nonlinearly with increase in concentration of sugar syrup in the honey. The dielectric loss at 2 MHz, and the relaxation frequency of the mixture increases linearly with increase in concentration of sugar syrup in honey, which can be used to estimate the amount of adulteration of honey by sugar syrup.
Effects of high current density on the characteristics of zinc films electroplated in ethaline electrolyte
Authors: Zhang Shubo , Jiang Fan , Kuang Yilong , Xie Zhongjun , Zhu Tianqi , Li Shaofu , Hu Chaoquan 
Published: August 2022

Abstract
Zinc coatings on Cu substrates were successfully electroplated from choline chloride (ChCl) with ethylene glycol (EG) based deep eutectic solvent with the current density varied from 10 to 40 mA cm−2 in air atmosphere at a temperature of 343 K. The effects of current density on the microstructure and corrosion performance were investigated in this paper. Smooth zinc coatings were obtained at the current density of 10 mA cm−2 with a current efficiency of over 90 %. With the increase in current density, there was a declining trend in the current efficiency and the surface quality of zinc coatings. Although there was no diffusion layer between the coating and substrates, all the zinc coatings still bonded well with the copper substrates. Compared with the smooth zinc coating electroplated at 10 mA cm−2, the zinc coating obtained at 40 mA cm−2 exhibited a better corrosion resistance in 3.5 wt.% NaCl aqueous solution due to the dense packing of the large number of flake zinc grains.
Seroprevalence and genotype distribution of hepatitis A virus in the pre-vaccine era in South Transdanubia, Hungary (2010–2020)
Authors: Reuter Gábor , Boros Ákos , Pankovics Péter 
Published: August 2022

Abstract
In this study, the age-related seroprevalence of hepatitis A virus (HAV) infection was investigated in the population in South-Transdanubia, Southwest Hungary (Central Europe) between years 2010 and 2020. Up to the age of 40, the HAV seropositivity was less than 18% in all age groups indicating a low level of HAV endemicity in this part of the country in the covered study period. The HAV seropositivity started to increase at the age group 41–45 years, reaching the ∼50% at age group 56–60, and 75–80% at age group 66–70, respectively. A total of 43 (0.2%) of the 21,106 tested sera were HAV IgM-positive (the annual percentage range of HAV IgM-positivity was 0.046–0.6%). Total of 24 (55.8%) of the 43 HAV IgM-positive samples tested RT-PCR-positive confirmed as HAV sub-genotypes IA (N = 17; 70.8%) and IB (N = 7; 29.2%), respectively. Imported HAV infections (three cases from Romania, and one-one case from Austria and Italy), two small outbreaks and 11 cases of a genetically identical sub-genotype IA strain (GenBank number of the prototype strain: KM657825) from 2012 to 2014 were identified later connected directly to the enormous HAV outbreak initiated among men who have sex with men (MSM) at the end of 2011 in the capital Budapest.
In summary, low endemicity but high and increased susceptibility for HAV infection was found in the population in Southwest Hungary, where repeated introduction of sub-genotypes IA and IB HAV strains were identified between 2010 and 2020.
Expression alteration analyses in the transgenic Arabidopsis carrying soybean Histidine-containing phosphotransmitter gene under salinity stress condition
Authors: Chi Hung Thai , Lan Xuan Hoang Thi , Thien Quang Nguyen , Phuong Thao Nguyen 
Published: August 2022

Productivity of many crops is highly vulnerable to extreme external conditions. Environmental stress factors such as drought and salinity have become more and more serious due to climate change and appear in many areas worldwide with higher frequency. As both drought and salinity belong to osmotic stress, they have similar negative effects on plant growth, development, and productivity as well as trigger similar stress responses by plants. In a previous study analyzing the expression profile in two soybean (Glycine max) cultivars with contrasting drought-tolerant phenotypes, a member of two-component system (TCS) in soybean, GmHP08, was proposed to associate with the plant tolerance capacity to drought. Subsequent in planta study confirmed its action as a positive regulator under drought conditions, as the transgenic Arabidopsis plants ectopically expressing GmHP08 acquired better drought tolerance. Following this, the presented research further explored the possible function of GmHP08 in mediating plant response to salinity. The obtained data from RT-qPCR analyses suggested that GmHP08 might positively enhance the salt tolerance of the Arabidopsis transgenic plants by altering the transcriptional abundance of several stress-related genes, including RD29A, RD29B, ABI5, SAG13, and CSD1. Activities of these genes are known to be associated with osmoprotection, senescence process, and antioxidation, which contribute to salt-tolerance ability of the transgenic plants. These results provided the first line of molecular evidence regarding GmHP08 function in plant response to salinity conditions. Therefore, extensive studies should be conducted in future studies to elaborate on the mechanisms by which this TCS member could improve various types of osmotic stress tolerance in plants.
Interações sócio-organizacionais midiatizadas: Ensaio sobre a intensificação da mediação técnica em meio à pandemia da Covid-19
Authors: Fernandes Fabio Frá , Barichello Eugenia Mariano da Rocha 
Published: August 2022

Objetiva-se aqui, elaborar um panorama sobre a intensificação das apropriações e usos dos ambientes de mídia por indivíduos e organizações enquanto recurso sociotécnico posto para mitigar questões relacionadas à sociabilidade em meio à pandemia da Covid-19. Por tratar-se de uma estudo teórico, com caráter ensaístico, orientado pelo método exploratório-descritivo, coletaram-se informações quantitativas sobre o acesso às tecnologias da informação e comunicação especificamente no Brasil desde o início do isolamento e distanciamento social. Ademais, acionam-se também os fluxos, trafego e o consumo de dados em rede no período. Do cenário identificado e de modo qualitativo, elaboram-se ensaios orientados ao alargamento das acepções analítico-investigativas sobre a mídia-ambiente em contexto de midiatização. Espera-se com tais ensaios, desvelar outras lentes para qualificar a compreensão de fenômenos, como a intensificação da mediação técnica em processos sócio-organizacionais.
Epidemiology and natural history of non-metastatic castration-resistant prostate cancer in Russia
Authors: Alekseev B. Ya. , Nyushko K. M. , Gafanov R. A. , Kirichek A. A. , Anzhiganova Yu. V. , Kopyltsov E. I. , Sundui Yu. Yu. , Pashanov Е. D. , Petyushin A. N. , Matveev V. B. 
Published: August 2022

Aim. To study the clinical and demographic profile of patients with non-metatstatic castration-resistant prostate cancer (nmCRPC) and clinical approaches to the treatment of nmCRPC in the context of daily medical practice before and after progression M1 stage.Materials and methods. The multicenter non-interventional epidemiological study were included 200 patients with a documented diagnosis of nmCRPC from 2019 to 2020. Each patient visited twice: start and after 6 months. Of the 200 patients included, 9 were excluded from the analysis presented in this article: 1 patient had no information on inclusi- on criteria, 1 patient did not meet the inclusion criteria, 7 patients did not attend visit 2. Thus, data are presented for 191 patients.Results and conclusion. The median age was 74.3 years (range 55 to 91). 72 % (137/191) had a disability group. The most common comorbidities were hypertension (n = 115) and hypercholesterolemia (n = 56). The median time from the diagnosis of prostate cancer to the development of castration resistance (diagnosis of nmCRPC) was 75 months. Prostate specific antigen (PSA) nadir (0.37 ng/ml on average) was achieved after 15 months of prostate cancer therapy (median time to reach PSA nadir). At the same time, PSA doubling time in most cases (47.6 %; 91/191) was less than 6 months, 18.8 % of persons (36/191) had PSA doubling time for more than 10 months.
Utility of fusion biopsy for choosing prostate cancer patients eligible for focal therapy
Authors: Romanov R. A. , Koryakin A. V. , Kirpatovskiy V. I. , Alekseev B. Ya. 
Published: August 2022

Background. Focal therapies for prostate cancer (PCa) can preserve the quality of life; however, their application is limited by lack of confidence in identifying the exact tumor location.Aim. To evaluate the utility of fusion biopsy for choosing PCa patients eligible for focal therapy with subsequent confirmation by the analysis of radical prostatectomy (RPE) samples.Materials and methods. This study included 122 patients with histologically verified stage Т1–2N0M0 PCa treated in N.A. Lopatkin Research Institute of Urology and Interventional Radiology, a branch of the National Medical Research Radiology Center. Their mean age was 65.2 ± 6.8 years. All patients underwent multiparametric magnetic resonance imaging and fusion biopsy (samples were collected from targeted areas in combination with a standard biopsy), followed by histological examination of biopsy samples and mapping of the affected areas. Twenty-eight patient underwent RPE.Results. Study participants were distributed as follows by their Prostate Imaging Reporting and Data System (PI-RADS) score: 5 points in 23 patients (18.9 %), 4 points in 57 patients (46.7 %), and 3 points in 42 patients (34.4 %). Targeted biopsy revealed cancer in 105 out of 122 patients (86.1 %) in at least one sample. Seventeen targeted biopsy samples were negative. The majority of patients had ISUP (International Society of Urological Pathology) grade 1 (n = 57; 46.8 %) and grade 2 (n = 33; 27.0 %) tumors. Comparison of biopsy findings and results of pathological examination of the removed prostate demonstrated significant discrepancies in the distribution of cases by their ISUP grades. Almost half of the patients (46.8 %) were diagnosed with ISUP grade 1 tumors after biopsy, while the assessment of RPE specimen demonstrated ISUP grade 1 tumors only in 21.4 % of patients. ISUP grade 3 tumors were diagnosed in 16.4 % and 35.7 % of patients using biopsy- and RPE-derived specimens, respectively. The proportions of ISUP grade 2, 4, and 5 tumors were similar with both methods. In 27 out of 28 cases, examination of biopsy- and RPE-derived specimens demonstrated complete agreement in terms of tumor location. Importantly, this study included only patients with histologically confirmed PCa; so we didn’t evaluate the effectiveness of biopsy for cancer diagnosis. Focal therapy could have been considered in 22 out of 28 patients (78.6 %) who underwent RPE. This proportion of focal therapy-eligible patients is almost equal to that identified by fusion biopsy (75.4 %).Conclusion. Multiparametric magnetic resonance imaging in combination with targeted and multifocal prostate biopsy allow precise identification of candidates eligible for focal therapy with a relatively low risk of an erroneous conclusion.
Pelvic lymphadenectomy for radical prostatectomy: perioperative and oncological results
Authors: Popov S. V. , Guseynov R. G. , Orlov I. N. , Skryabin O. N. , Perepelitsa V. V. , Katunin А. S. , Mirzabekov M. M. , Zaytsev A. S. , Yasheva S. Yu. 
Published: August 2022

Background. Currently, in men suffering from prostate cancer, histological examination of the material obtained during pelvic lymphadenectomy (PLAE) is the most accurate and reliable method for staging the tumor process and postoperative prognosis of disease outcomes, an important factor influencing the choice of the most rational treatment tactics after radical prostatectomy. However, today questions about the therapeutic (oncological) expediency of PLAE and its safety in terms of the development of intra- and postoperative complications remain debatable.Aim. To was to compare the perioperative and therapeutic (oncological) results of radical prostat ectomy performed in combination with standard or extended PLAE.Materials and methods. The study materials were the data of medical records of 812 men aged 43 to 78 years, at different times (from January 2009 to December 2018) who were hospitalized for localized or locally advanced prostate cancer in stages cT1a–cT3bN0M0. The research method was a retrospective analysis of the data contained in the selected medical records.Results and conclusion. The results of our studies, firstly, confirm the conclusions of the European Association of Urology (EAU) experts on the justification and necessity of performing an extended PLAE with radical prostatectomy in order to diagnose metastatic lesions of the pelvic lymph nodes in individuals with an intermediate or high risk of prostate cancer progression; secondly, they indicate a higher therapeutic efficacy of extended PLAE compared to that for standard PLAE, which is expressed in a statistically significantly three times lower incidence of biochemical relapses and an 11.4 % longer relapse-free period after extended PLAE than after standard PLAE. Extended PLAE, performed in one surgical session with radical prostatectomy, is not a risk factor for the development of various intra- and postoperative complications, with the exception of the lymphocele, which is formed in 3.7–13.5 % of cases of extended PLAE due to intraoperative transection of lymphatic vessels and lymph accumulation at the site of the removed adipose tissue.
Bladder neck-sparing retropubic radical prostatectomy: assessing risk factors for detection of positive surgical margins
Authors: Belousov I. I. , Kogan M. I. , Tokhtamishyan S. K. , Chibichyan M. B. 
Published: August 2022

Background. Bladder neck preservation during retropubic radical prostatectomy (rRP) promotes a protective effect on urinary continence compared to standard rRP.Aim. To assessment of possible predictors for positive surgical margin (PSM) recognition is an important step.Materials and methods. 136 patients with localized prostate cancer (PCa) were studied in the study. Group 1, 90 patients (retrospective assessment), underwent standard rRP, group 2, 46 patients (prospective assessment), underwent rRP modified by bladder neck preservation with a part of the proximal prostatic urethra. The clinical and pathological stages of PCa were assessed; the groups were compared to the parameter PSM. Statistical analysis was performed using nonparametric statistical methods.Results. Both groups were comparable in age and baseline total prostate specific antigen (PSA) but differed in prostate volume and Gleason score. Also, there were differences in clinical and pathological stages of PCa. PSM-patients had more aggressive PCa according to the International Society of Urological Pathology (ISUP) and TNM classifications and had higher progression risk prognosis stages. In PSM-patients, correlations were determined between prostate volume and baseline Gleason index (r = 0.338; p >0.05); baseline total PSA and Gleason score before (r = 0.529; p >0.05) and after (r = 0.310; p >0.05) rRP, respectively. Nevertheless, the incidence of PSM among all subjects was 6.6 % of cases, while in groups 1 and 2 was 7.8 and 4.3 % of cases, respectively. In this way, surgical techniques that maximize bladder neck preservation with a part of proximal prostatic urethra have no significant effect on PSM. Ranges of total PSA, clinical stage of PCa, Gleason score and progression risk stages (prognostic group for PCa) were determined as predictors of PSM. Their use will make it possible to establish patient selection criteria for bladder neck preservation with proximal prostatic urethra during rRP.Conclusion. The identified predictors will allow determining during clinical staging minimal risks of detecting PSM. The rRP modified by bladder neck preservation with part of the proximal prostatic urethra does not increase the incidence of PSM compared to the standard rRP. The feasibility of this technique should be related to total PSA, clinical stage of PCa, Gleason score, and the progression risk stage.
The Level of Knowledge and Nurse Attitude in the Application of Five Moments Hand Hygiene in a Private Hospital in the Western part of Indonesia
Authors: Larosa Cornelia Ayu Kristina , Panjaitan Criesty Fransiska Junita , Ingrit Belet Lydia , Panjaitan Tirolyn 
Published: August 2022

<p class="paragraph">Hand hygiene is very important for health workers to reduce infection rates in health services area. Five Moments Hand Hygiene is one of strategy for health workers to keep safe from infections. Knowledge and attitudes by nurses about hand hygiene can influence nurse behavior and have an impact to improving patient health for reducing the spread of infection. To describe the level of knowledge and attitudes of nurses in applying the Five Moments Hand Hygiene in a Private Hospital in Wester part of Indonesia. This study used descriptive quantitative with the population are all nurses and the sample in this study were 46 nurses with total sampling technique. The instrument in the study used a questionnaire with level of knowledge and nurse attitude as variables. The data analysis technique is univariate. This study used ethical principles and has received ethical approval from The Research Committee Ethic Faculty of Nursing. The study shows that nurses had a good (80,43%) knowledge of Five Moments Hand Hygiene but had a sufficient (54,35%) attitude in applying the Five Moments Hand Hygiene. Conclusion of this study is that most nurses have good knowledge but have sufficient attitude in applying Five Moments Hand Hygiene. For further researchers, it is recommended to find the relationship between knowledge and attitudes of nurses in applying the Five Moments Hand Hygiene.</p>
Profil keterampilan metakognitif siswa pada pembelajaran biologi secara online di masa pandemi covid-19
Authors: Setyawati Octaviana Ika , Fitakurahmah Nur 
Published: August 2022

<p>Pendidikan di abad 21 menuntut peserta didik memiliki keterampilan yang mampu menunjang aktivitasnya di dunia kerja. Keterampilan yang dibutuhkan antara lain keterampilan pemecahan masalah, komunikasi, dan metakognitif. Aktivitas metakognitif berhubungan dengan pengorganisasian informasi, pengalaman, tujuan, dan strategi yang mendukung pemecahan masalah. Penelitian ini bertujuan untuk mengungkap profil keterampilan metakognitif siswa SMA dalam pembelajaran biologi online selama masa pandemi Covid-19. Keterampilan metakognitif adalah kemampuan seseorang untuk mengontrol proses berpikir. Penelitian ini merupakan jenis penelitian kualitatif. Teknik pengumpulan data menggunakan metode survei. Survei dilakukan dengan menyebarkan google form yang berisi kuesioner MAI (Metacognitive Awareness Inventory) kemudian dianalisis dengan menggunakan persentase deskriptif. Populasi penelitian ini adalah seluruh siswa SMA. Sampel penelitian ini adalah sampel acak seluruh siswa. Subyek dipilih dengan menggunakan teknik random sampling. Hasil survei digunakan untuk mengetahui data tentang kemampuan metakognitif siswa. Hasil keterampilan metakognitif siswa dari setiap aspek adalah kondisional 26,7%, perencanaan 24,3%, pemantauan 22,8%, deklaratif 20,5%, prosedural 20,3%, dan evaluasi 17,8%.</p><div> </div><div><em><strong>Metacognitive skills profile of students on online biological learning during the covid-19 pandemic</strong>. Education in the 21st century requires students to have skills that are able to support their activities in the world of work. The skills needed include problem solving, communication, and metacognitive skills. Metacognitive activities relate to organizing information, experiences, goals, and strategies that support problem solving. This study aims to reveal the profile of high school students' metacognitive skills in online biology learning during the Covid-19 pandemic. Metacognitive skills are a person's ability to control the thinking process. This research is a type of qualitative research. The technique of collecting data using survey methods. The survey was conducted by distributing a google form containing the MAI (Metacognitive Awareness Inventory) questionnaire then analyzed by using a descriptive percentage. The study population was all high school students. The research sample was a random sample of all students. Subjects were selected using random sampling technique. The survey results were used to find out data about students' metacognitive skills. The results of students' metacognitive skills from every aspect were 26.7% conditional, 24.3% planning, 22.8% monitoring, 20.5% declarative, 20.3% procedural, and 17.8% evaluation.</em></div>