bluuebunny/crossref_metadata_2025_split huggingface dataset:
Grating-free 2.8 μm Er:ZBLAN fiber chirped pulse amplifier
Authors: Zhou Yicheng , Qin Zhipeng , Zhou Xiabing , Xie Guoqiang 
Published: November 2022

Abstract
We report on a grating-free fiber chirped pulse amplifier (CPA) at 2.8 μm for the first time. The CPA system adopted Er:ZBLAN fiber with large anomalous dispersion as the stretcher and germanium (Ge) rods as the compressor with a compact structure. High-energy picosecond pulses of 2.07 μJ were generated at the repetition rate of 100 kHz. Using highly dispersive Ge rods, the amplified pulses were compressed to 408 fs with a pulse energy of 0.57 μJ, resulting in a peak power of approximately 1.4 MW. A spectral broadening phenomenon in the main amplifier was observed, which was caused by the special gain shape of the Er:ZBLAN fiber amplifier in operation and confirmed by our numerical simulation. This compact fiber CPA system at 2.8 μm will be practical and meaningful for application fields.
The Growth of Finance is Not Remarkable
Authors: Brown James R. , Martinsson Gustav , Petersen Bruce C. 
Published: November 2022

AbstractAn important literature emphasizes that finance grew rapidly after WWII relative to the full economy and the services sector, but these are poor benchmarks because they mask a broad structural shift from low- to high-skill services. We show that i) finance is among the most skill-intensive service industries, ii) the evolution of the finance income share closely tracks other high-skill service industries, and iii) finance grew much slower than the rest of high-skill services in the post-WWII period. The rise of modern finance is not as remarkable as prior research suggests, providing context for debates about the size of finance.
Detailed analysis of cytoplasmic strings in human blastocysts: new insights
Authors: Eastick Jessica , Venetis Christos , Cooke Simon , Chapman Michael 
Published: November 2022

SummaryThe aim of this study was to determine if there was an association between the presence of cytoplasmic strings (CS) and their characteristics, with blastocyst quality, development and clinical outcome in human blastocysts. This two-centre cohort study was performed between July 2017 and September 2018 and involved a total of 1152 blastocysts from 225 patients undergoing in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). All embryos were cultured in Embryoscope+ and were assessed for CS using time-lapse images. A single assessor examined all blastocysts and reviewed videos using the EmbyroViewer® Software. Blastocyst quality was assessed on day 5 of embryo development. The number of CS, location and duration of their activity was recorded on days 5/6. A positive association between the presence of CS in human blastocysts with blastocyst quality was identified. Blastocysts with a higher number of CS present, were of higher quality and were in the more advanced stages of development. Top quality blastocysts had CS activity present for longer, as well as having a higher number of vesicles present travelling along the CS. Blastocysts that had CS present, had a significantly higher live birth rate. This study has confirmed that a higher number of CS and vesicles in human blastocysts is associated with top quality blastocysts and is not a negative predictor of development. They had a higher number of CS present that appeared earlier in development and, although ceased activity sooner, had a longer duration of activity. Blastocysts with CS had a significant increase in live birth rate.
Property rights aren't primary; ideas are
Authors: Wilson Bart J. 
Published: November 2022

AbstractThe current approach to the study of property cannot distinguish the causes of human action from the consequences of human action. It also cordons off morality thereby opening a hole in how property rights work. The scientific difficulty is that our analysis must constantly shift between the individual, their local community, and the larger polity in which both are embedded, in order to explain simultaneously different levels of consequences with different kinds of causes. The difficulty is made worse when we construct mental models without the human mind. My framework leaves the human mind in. Since Armen Alchian and Harold Demsetz, the study of property rights has had a decidedly external stance: the institution imposes itself on the individual from the outside. The problem of property rights, however, also calls for inquiry from the inside out of human agency, because in the study of property, ideas are primary.
Target-site and metabolic mechanisms of tolerance to penoxsulam in pond lovegrass (Eragrostis japonica)
Authors: Liu Ying , Wang Hao , Fang Jiapeng , Gao Haitao , Chen Jinyi , Peng Zhen , Dong Liyao 
Published: November 2022

AbstractThe identification of herbicide tolerance is essential for effective chemical weed control. According to whole-plant dose–response assays, none of 29 pond lovegrass [Eragrostis japonica (Thunb.) Trin.] populations were sensitive to penoxsulam. The effective dose values of penoxsulam causing 50% inhibition of fresh weight (GR50: 105.14 to 148.78 g ai ha−1) in E. japonica populations were much higher than the label rate of penoxsulam (15 to 30 g ai ha−1) in the field. This confirmed that E. japonica was tolerant to penoxsulam. Eragrostis japonica populations showed 52.83- to 74.76-fold higher tolerance to penoxsulam than susceptible barnyardgrass [Echinochloa crus-galli (L.) P. Beauv.]. The mechanisms of tolerance to penoxsulam in E. japonica were also identified. In vitro activity assays revealed that the penoxsulam concentration required to inhibit 50% of the acetolactate synthase (ALS) activity (IC50) was 12.27-fold higher in E. japonica than in E. crus-galli. However, differences in the ALS gene, previously found to endow target-site resistance in weeds, were not detected in the sequences obtained. Additionally, the expression level of genes encoding ALS in E. japonica was approximately 2-fold higher than in E. crus-galli after penoxsulam treatment. Furthermore, penoxsulam tolerance can be significantly reversed by three cytochrome P450 monooxygenase (CytP450) inhibitors (1-aminobenzotriazole, piperonyl butoxide, and malathion), and the activity of NADPH-dependent cytochrome P450 reductase toward penoxsulam in E. japonica increased significantly (approximately 7-fold higher) compared with that of treated E. crus-galli. Taken together, these results indicate that lower ALS sensitivity, relatively higher ALS expression levels, and stronger metabolism of CytP450s combined to bring about penoxsulam tolerance in E. japonica.
Microphysical Structure of Thunderstorms and Their Lightning Activity During the mei‐yu and Post‐mei‐yu Periods Over Nanjing, Yangtze River Delta
Authors: Yang Ji , Zhao Kun , Zheng Yuanyuan , Chen Haonan , Chen Gang 
Published: November 2022

AbstractUsing polarimetric radar, cloud‐to‐ground (CG) lightning, and reanalysis data, this study examined the microphysical structures of thunderstorm and their environmental impact during two active monsoon periods over Nanjing, Yangtze River Delta. The results show that the mei‐yu thunderstorm presented a large area of radar echo and many graupels between 0 and −10°C levels; these were accompanied by large vertical wind shear, which was favorite for the organization of thunderstorm. Broad updrafts within the mei‐yu thunderstorms were hypothesized, causing lower amount of dilution and entrainment, facilitating transportation of supercooled liquid water to the mixed‐phase region and producing CG lightning. Due to large atmospheric instability, strong updrafts within the post‐mei‐yu thunderstorm were expected to supply supercooled liquid water for the riming process to form more graupel above −10°C level. These provided favorable conditions for electrification, resulting in more CG lightning during the post‐mei‐yu period than during the mei‐yu period.
Global Mapping of Mesoscale Eddy Vertical Tilt
Authors: Li Hong , Xu Fanghua , Wang Guihua 
Published: November 2022

AbstractVertical motion induced by oceanic mesoscale eddies can strengthen ocean ventilation, and regulate vertical distribution of heat, dissolved CO2 and other tracers on a global scale. Eddy‐induced vertical motion is closely related to eddy vertical structure. Here, based on available satellite observations and Argo profiles, we find that mesoscale eddies in global oceans are prevalently vertical tilted. Anticyclonic eddies are frequently tilted westward and poleward from 300 dbar up to sea surface, while cyclonic eddies are frequently tilted westward and equatorward. The horizontal tilting distance of eddies is significantly correlated (r ≥ 0.84) with the Burger number (the ratio of vertical stratification to planetary rotation and eddy size), indicating a strong constraint of Earth's rotation and ocean stratification on eddy vertical tilt. On average, the maximum vertical velocity in tilted circular eddies is at least one order of magnitude larger than that in non‐tilted circular eddies. This finding would improve estimates of eddy‐induced vertical motion, ventilation, so as to heat/salt and biogeochemical responses.
Scalings for Eddy Buoyancy Fluxes Across Prograde Shelf/Slope Fronts
Authors: Wei Huaiyu , Wang Yan , Stewart Andrew L. , Mak Julian 
Published: November 2022

AbstractDepth‐averaged eddy buoyancy diffusivities across continental shelves and slopes are investigated using a suite of eddy‐resolving, process‐oriented simulations of prograde frontal currents characterized by isopycnals tilted in the opposite direction to the seafloor, a flow regime commonly found along continental margins under downwelling‐favorable winds or occupied by buoyant boundary currents. The diagnosed cross‐slope eddy diffusivity varies by up to three orders of magnitude, decaying from in the relatively flat‐bottomed region to over the steep continental slope, consistent with previously reported suppression effects of steep topography on baroclinic eddy fluxes. To theoretically constrain the simulated cross‐slope eddy fluxes, we examine extant scalings for eddy buoyancy diffusivities across prograde shelf/slope fronts and in flat‐bottomed oceans. Among all tested scalings, the GEOMETRIC framework developed by D. P. Marshall et al. (2012, https://doi.org/10.1175/JPO-D-11-048.1) and a parametrically similar Eady scale‐based scaling proposed by Jansen et al. (2015, https://doi.org/10.1016/j.ocemod.2015.05.007) most accurately reproduce the diagnosed eddy diffusivities across the entire shelf‐to‐open‐ocean analysis regions in our simulations. This result relies upon the incorporation of the topographic suppression effects on eddy fluxes, quantified via analytical functions of the slope Burger number, into the scaling prefactor coefficients. The predictive skills of the GEOMETRIC and Eady scale‐based scalings are shown to be insensitive to the presence of along‐slope topographic corrugations. This work lays a foundation for parameterizing eddy buoyancy fluxes across large‐scale prograde shelf/slope fronts in coarse‐resolution ocean models.
Heterogeneity in treatment outcomes and incomplete recovery in first episode psychosis: does one size fit all?
Authors: Griffiths Siân Lowri , Lalousis Paris Alexandros , Wood Stephen J. , Upthegrove Rachel 
Published: November 2022

AbstractThe heterogeneity in recovery outcomes for individuals with First Episode Psychosis (FEP) calls for a strong evidence base to inform practice at an individual level. Between 19–89% of young people with FEP have an incomplete recovery despite gold-standard evidence-based treatments, suggesting current service models, which adopt a ‘one-size fits all’ approach, may not be addressing the needs of many young people with psychosis. The lack of consistent terminology to define key concepts such as recovery and treatment resistance, the multidimensional nature of these concepts, and common comorbid symptoms are some of the challenges faced by the field in delineating heterogeneity in recovery outcomes. The lack of robust markers for incomplete recovery also results in potential delay in delivering prompt, and effective treatments to individuals at greatest risk. There is a clear need to adopt a stratified approach to care where interventions are targeted at subgroups of patients, and ultimately at the individual level. Novel machine learning, using large, representative data from a range of modalities, may aid in the parsing of heterogeneity, and provide greater precision and sophistication in identifying those on a pathway to incomplete recovery.
Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis
Authors: Boiarsky Rebecca , Haradhvala Nicholas J. , Alberge Jean-Baptiste , Sklavenitis-Pistofidis Romanos , Mouhieddine Tarek H. , Zavidij Oksana , Shih Ming-Chieh , Firer Danielle , Miller Mendy , El-Khoury Habib , Anand Shankara K. , Aguet François , Sontag David , Ghobrial Irene M. , Getz Gad 
Published: November 2022

AbstractMultiple myeloma is a plasma cell malignancy almost always preceded by precursor conditions, but low tumor burden of these early stages has hindered the study of their molecular programs through bulk sequencing technologies. Here, we generate and analyze single cell RNA-sequencing of plasma cells from 26 patients at varying disease stages and 9 healthy donors. In silico dissection and comparison of normal and transformed plasma cells from the same bone marrow biopsy enables discovery of patient-specific transcriptional changes. Using Non-Negative Matrix Factorization, we discover 15 gene expression signatures which represent transcriptional modules relevant to myeloma biology, and identify a signature that is uniformly lost in abnormal cells across disease stages. Finally, we demonstrate that tumors contain heterogeneous subpopulations expressing distinct transcriptional patterns. Our findings characterize transcriptomic alterations present at the earliest stages of myeloma, providing insight into the molecular underpinnings of disease initiation.
Nickel-catalyzed switchable 1,3-dienylation and enantioselective allenylation of phosphine oxides
Authors: Zhang Jiayin , Chang Xihao , Xu Xianghong , Wang Hongyi , Peng Lingzi , Guo Chang 
Published: November 2022

AbstractThe development of general catalytic methods for the regio- and stereoselective construction of phosphoryl derivatives from identical substrates remains a formidable challenge in organic synthesis. Enabled by the newly developed BDPP-type ligands, we disclosed a nickel-catalyzed allenylation of phosphine oxides rationally and predictably, allowing the construction of versatile chiral allenylphosphoryl derivatives with high enantiopurity (up to 94% e.e.). Alternatively, using an achiral phosphine ligand dcypbz under acidic conditions, we achieved a regiochemical switch of the 1,3-dienylation to afford functionalized phosphinoyl 1,3-butadienes (up to 93% yield). The salient features of this method include switchable reactivity, broad substrate scope, readily available feedstock, single-step preparation, and high asymmetric induction.
Constructing molecular bridge for high-efficiency and stable perovskite solar cells based on P3HT
Authors: Xu Dongdong , Gong Zhiming , Jiang Yue , Feng Yancong , Wang Zhen , Gao Xingsen , Lu Xubing , Zhou Guofu , Liu Jun-Ming , Gao Jinwei 
Published: November 2022

AbstractPoly (3-hexylthiophene) (P3HT) is one of the most attractive hole transport materials (HTMs) for the pursuit of stable, low-cost, and high-efficiency perovskite solar cells (PSCs). However, the poor contact and the severe recombination at P3HT/perovskite interface lead to a low power conversion efficiency (PCE). Thus, we construct a molecular bridge, 2-((7-(4-(bis(4-methoxyphenyl)amino)phenyl)−10-(2-(2-ethoxyethoxy)ethyl)−10H-phenoxazin-3-yl)methylene)malononitrile (MDN), whose malononitrile group can anchor the perovskite surface while the triphenylamine group can form π−π stacking with P3HT, to form a charge transport channel. In addition, MDN is also found effectively passivate the defects and reduce the recombination to a large extent. Finally, a PCE of 22.87% has been achieved with MDN-doped P3HT (M-P3HT) as HTM, much higher than the efficiency of PSCs with pristine P3HT. Furthermore, MDN gives the un-encapsulated device enhanced long-term stability that 92% of its initial efficiency maintain even after two months of aging at 75% relative humidity (RH) follow by one month of aging at 85% RH in the atmosphere, and the PCE does not change after operating at the maximum power point (MPP) under 1 sun illumination (~45oC in N2) over 500 hours.
A linear Di-coordinate boron radical cation
Authors: Lin Yu-Jiang , Liu Wei-Chun , Liu Yi-Hung , Lee Gene-Hsiang , Chien Su-Ying , Chiu Ching-Wen 
Published: November 2022

AbstractThe pursuit of di-coordinate boron radical has been continued for more than a half century, and their stabilization and structural characterization remains a challenge. Here we report the isolation and structural characterization of a linear di-coordinate boron radical cation, achieved by stabilizing the two reactive atomic orbitals of the central boron atom by two orthogonal π-donating and π-accepting functionalities. The electron deficient radical cation undergoes facile one-electron reduction to borylene and binds Lewis base to give heteroleptic tri-coordinate boron radical cation. The co-existence of half-filled and empty p orbitals at boron also allows the CO-regulated electron transfer to be explored. As the introduction of CO promotes the electron transfer from a tri-coordinate neutral boron radical to a boron radical cation, the removal of CO under vacuum furnishes the reverse electron transfer from borylene to yield a solution consisting of two boron radicals.
RS-FISH: precise, interactive, fast, and scalable FISH spot detection
Authors: Bahry Ella , Breimann Laura , Zouinkhi Marwan , Epstein Leo , Kolyvanov Klim , Mamrak Nicholas , King Benjamin , Long Xi , Harrington Kyle I. S. , Lionnet Timothée , Preibisch Stephan 
Published: November 2022

AbstractFluorescent in-situ hybridization (FISH)-based methods extract spatially resolved genetic and epigenetic information from biological samples by detecting fluorescent spots in microscopy images, an often challenging task. We present Radial Symmetry-FISH (RS-FISH), an accurate, fast, and user-friendly software for spot detection in two- and three-dimensional images. RS-FISH offers interactive parameter tuning and readily scales to large datasets and image volumes of cleared or expanded samples using distributed processing on workstations, clusters, or the cloud. RS-FISH maintains high detection accuracy and low localization error across a wide range of signal-to-noise ratios, a key feature for single-molecule FISH, spatial transcriptomics, or spatial genomics applications.
The impact of environmental and climatic variables on genetic diversity and plant functional traits of the endangered tuberous orchid (Orchis mascula L.)
Authors: Mafakheri Mohammad , Bakhshipour Mehdi , Omrani Mina , Gholizadeh Hamid , Rahimi Najmeh , Mobaraki Ali , Rahimi Mehdi 
Published: November 2022

AbstractUnderstanding how environmental factors shape patterns of genetic and phenotypic variations in a species is necessary for conservation and plant breeding. However, these factors have not yet been completely understood in tuberous orchid species used to make ‘Salep’, an important ingredient in traditional medicine and beverages in middle eastern countries and India. In many areas, increasing demand has pushed species to the brink of extinction. In this study, 198 genotypes from 18 populations of the endangered speciesOrchis masculaL. spanning a large-scale climatic gradient in northern Iran were used to investigate patterns of genetic diversity and plant functional traits. Populations were sampled from three land cover types (woodland, shrubland, and pastureland/grassland). Plant height, stem length, number of flowers, bulb fresh and dry weight, glucomannan, and starch concentrations showed high variation among populations and were significantly related to land cover type. In general, genetic diversity was high, particularly in those from eastern Hyrcanian; additionally, populations showed a high level of genetic differentiation (G'st = 0.35) with low gene flow (Nm = 0.46). The majority of genetic differentiation occurred within populations (49%) and land cover types (20%). The population structural analysis using the AFLP marker data in K = 4 showed a high geographical affinity for 198O. masculagenotypes, with some genotypes having mixed ancestry. Temperature and precipitation were found to shape genetic and phenotypic variation profoundly. Significant isolation by the environment was observed, confirming the strong effect of environmental variables on phenotypic and genetic variation. Marker-trait association studies based on MLM1 and MLM2 models revealed significant associations of P-TGG + M-CTT-33 and E-AGG + M-CGT-22 markers with plant height and glucomannan content. Overall, a combination of large-scale climatic variables and land cover types significantly shaped genetic diversity and functional trait variation inO. masculapopulations.
Superatomic icosahedral-CnB12-n (n = 0, 1, 2) Stuffed mononuclear and binuclear borafullerene and borospherene nanoclusters with spherical aromaticity
Authors: Zhang Min , Jia Wei-Ping , Zhang Ting , Pei Bin-Bin , Xu Jia , Tian Xinxin , Lu Hai-Gang , Li Si-Dian 
Published: November 2022

AbstractBoron and boron-based nanoclusters exhibit unique structural and bonding patterns in chemistry. Extensive density functional theory calculations performed in this work predict the mononuclear walnut-like Ci C50B54 (1) (C2B10@C48B44), C1 C50B54 (2) (CB11@C49B43), and S10 C50B54 (3) (B12@C50B42) which contain one icosahedral-CnB12-n core (n = 0, 1, 2) at the center following the Wade’s skeletal electron counting rules and the approximately electron sufficient binuclear peanut-like Cs C88B78 (4) ((C2B10)2@C84B58), Cs C88B78 (5) ((CB11)2@C86B56), Cs C88B78 (6) ((B12)2@C88B54), Cs B180 (7) ((B12)2@B156), Cs B182 (8) ((B12)2@B158), and Cs B184 (9) ((B12)2@B160) which encapsulate two interconnected CnB12-n icosahedrons inside. These novel core–shell borafullerene and borospherene nanoclusters appear to be the most stable species in thermodynamics in the corresponding cluster size ranges reported to date. Detailed bonding analyses indicate that the icosahedral B122−, CB11−, and C2B10 cores in these core–shell structures possess the superatomic electronic configuration of 1S21P61D101F8, rendering spherical aromaticity and extra stability to the systems. Such superatomic icosahedral-CnB12-n stuffed borafullerenes and borospherenes with spherical aromaticity may serve as embryos to form bulk boron allotropes and their carbon-boron binary counterparts in bottom-up approaches.