bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Prediction of Gestational Diabetes Mellitus Using Placental Strain Elastography and Subcutaneous Adipose Tissue Thickness
Authors: sengul mustafa , Selim Halime Sen 
Published: September 2022

Abstract
Purpose: The aim of this study is to investigate the efficacy of placental strain ratio values measured by real-time sonoelastography and maternal subcutaneous adipose tissue thickness measured by two-dimensional ultrasonography in predicting gestational diabetes mellitus in the first trimester.
Methods:
The population of the study consisted of the first 210 consecutive singleton pregnant women who applied for routine first-trimester screening between the 11th and 14th weeks of gestation.B-mode subcutaneous adipose tissue thickness sonography and real-time placental strain elastography scanning were performed.All patients underwent 75 g oral glucose tolerance test between the 24th and 28th weeks of gestation. American Diabetes Association criteria were used in the diagnosis of gestational diabetes mellitus.
Results: It was observed that body mass index (p<0.001), first-trimester fasting blood sugar (p<0.001), subcutaneous adipose tissue thickness (p<0.001), and placental strain ratio value (p<0.001) affected the development of gestational diabetes mellitus statistically.
The multivariate analysis shown that subcutaneous adipose tissue thickness (Odds ratio=1.271, 95%CI=1.142-1.416, p<0.001) and placental strain ratio value (Odds ratio=3.664, 95%CI=1.927- 6.969, p<0.001) were the independent risk factors affecting the development of gestational diabetes mellitus.
Conclusions: The findings of this study indicated a positive correlation between 75 g oral glucose tolerance test application and first trimester subcutaneous adipose tissue thickness and placental strain ratio. Using the cut-off values of >11.5 mm for subcutaneous adipose tissue and > 0.986 for placental strain ratio, the development of gestational diabetes mellitus may be predicted in the early weeks of pregnancy.
Enterprise Marketing Management and Innovation Driven by Intelligent IoT
Authors: Tang Li 
Published: September 2022

Abstract
With the extended unraveling of advertisement technology in our unpolished, our rude has ex cathedra inscribe the date of Informa ionization. The popularization and deduction of notice technology has turn community's lifestyles and also raise the metamorphosis and upgrading of variable industries, peculiarly major league data technology. The evolution of China has vary the fundamental supplies plan of possession-owned enterprises. Data has turn the fundamental conventionality of teaching stowage and wording. Only by realizing the sensible usefulness of data and message and transpeciate the old-fashioned supplies design can it raise the fin de siecle eduction of quality-owned enterprises and exaggerate their traffic fight. This distinct will finish the request foresight of major league data analysis, gross data supplies, the apposition of build data analysis in the supplies of possession-owned enterprises, and the ingress stage of the recourse of build data analysis in the supplies of quality-owned enterprises for advertence.
A Report on 18 Cases of Children with Kimura Disease in China and Literature Review
Authors: Zhou Qingfang , Weng Ruohang , Wang Linlin , Luo Ying , He Tingyan , Yang Jun , Xia Yu 
Published: September 2022

Abstract
Background: Kimura’s disease (KD), also known as Eosinophilic Granuloma, is a benign, rare and chronic inflammatory disorder of unknown etiology and it affects subcutaneous tissues, lymph nodes, and salivary glands. Unusual presentations of KD might cause diagnostic difficulty or be misdiagnosed as malignancy if clinical suspicion is insufficiently high. Here, we aimed to explore the clinical characteristics, diagnosis and the therapeutic effect of children’s KD in China, in order to improve pediatricians’ knowledge of children’s KD.
Methods: The Clinical data of 18 cases of KD diagnosed at Shenzhen Children's Hospital from January 2015 to January 2022 were analyzed retrospectively through case record review.
Results: Of 18 cases, 17 were male and one is female. The masses appear as focal, painless, and immovable with an unclear boundary. The most common predilection is head-neck region (n=8, 44.4%). 12 patients showed cutaneous pruritus, 3 patients with nephrotic syndrome and 2 with simple hematuria. 16 patients showed peripheral blood eosinophilia. 12 of 13 patients presented with increased serum Immunoglobulin E (IgE) level. The prominent pathological characteristic is marked lymphoid hyperplasia accompanied by various degrees of vascular hyperplasia and eosinophil infiltration. Among the 18 patients followed for more than 6 months, 9 experienced recurrence of disease after treatment (surgical resection alone: 6/12; oral corticosteroids combined with immunosuppressants: 3/3; surgical resection followed by oral corticosteroids combined with immunosuppressants: 0/3). Through comparison with the clinical features of adult kimura disease, it showed that there was no significant difference between children and adults.
Conclusion: KD is characterized by subcutaneous masses but it is also a systemic disease. The diagnosis should be confirmed by pathology. Surgical resection, radiotherapy, hormone or chemotherapy has definite therapeutic effects, but the rate of recurrence in children is high. Given the high rate of recurrence and reported association with lymphoma, patients require careful long-term follow-up.
Public Health Supply Chain Performance of Primary Health Care Units, Gamo zone, SNNPR, Ethiopia
Authors: Alemu Aynoshe Adio , Fenta Teferi Gedif , Gebregeorgise Dawit Teshome 
Published: September 2022

Abstract
Method
A convergent parallel mixed-method was adopted. Quantitative data were collected from 46 primary healthcare units between April 01 and May 30, 2021. The study employed stratified simple random sampling method. It was due to variation in LMIS reporting schedule; number and types of tracer drugs being handled; and pharmaceutical storage capacity among levels of primary healthcare units. Logistics records and reports, service registers, physical observation, and interview of key informants were sources of data. The data were analyzed by using SPSS version 20. The result was presented in mean, percentage, and standard deviation. Qualitative data on public health supply chain challenges were collected from key informants using a semi-structured interview guide. The data were analyzed manually using inductive thematic approach and the result was narrated.
Results
The study revealed that public health supply chain performance of primary health care unit in Gamo zone was low. Inventory management KPIs, LMIS report KPIs, and storage condition KPIs were below the national standard. Means of availability (64.8%±14.8%), stocked according to plan (16.5%±9.5%), inventory accuracy rate (65%±17.2%), and stock out rate (64.9%±9.8%) of tracer drugs in primary health care units deviate from ideal. Likewise, means of LMIS report accuracy rate (64%± 13.6%) and LMIS report completeness (80%±15) for primary healthcare units were lower than the standard. Only 81% of assessed primary health care units adhere to good storage practices. In general, public health supply chain performance decreases across the levels of primary health care units in Gamo zone. LMIS report quality; pharmaceutical distribution; storage condition; public transportation access; supply chain workforce training and motivation; budgeting and finance for logistics activity; and low management support were reported as prevailing challenges.
Conclusion
Inventory management, LMIS reporting, and storage practices are areas where public health supply chain performance gaps identified. These lead to wastage and interruption of essential medicines, affecting the quality of healthcare delivery at each level of primary healthcare unit.
The Efficacy of Antibiotic and α–Blocker Combination Therapy versus Antibiotic Monotherapy in Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Systematic Review
Authors: Agung Natanael , Widia Fina , Rahardjo Harrina , Rasyid Nur , Birowo Ponco , Taher Akmal 
Published: September 2022

Abstract
Objective
This study attempted to explore an alpha-blocker regimen's efficacy and antibiotics versus antibiotics as monotherapy in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
Methods
We searched the PubMed/MEDLINE, Cochrane/CENTRAL, EBSCOHost/CINAHL, ProQuest, and Scopus with specific keywords adjusted to each search engine on January 2020. Randomized controlled trials comparing antibiotics monotherapy with combination therapy of antibiotics and alpha-blockers in CP/CPPS patients, lasting at least four weeks, was included in the study. The study eligibility assessment, data extraction, and study quality assessment were carried out by each author independently and in duplication.
Results
A total of six low to high-quality studies, with 396 patients participating in the study. Two reviews reported lower NIH-CPSI total scores in the monotherapy arm at week six. Only one study reported otherwise. On day 90, the NIH-CPSI score was found to be lower in the combination group. In the pain, urinary, and quality of life domain, most studies agree that combination therapy is not superior to monotherapy. However, on day 90, all domains were found to be lower in the combination therapy arm. Responder rates were found to vary between studies. Only four out of six studies reported a response rate. Responder rates were lower in the combination group at six weeks of observation. On day 90, responder rates were found to be better in the combination group.
Conclusion
The combination therapy of antibiotics and alpha-blocker therapy is not substantially better than antibiotic monotherapy in the first six weeks of treatment for CP/CPPS patients. This result might not be applicable in a longer duration of treatment.
Illusion of Invulnerability, Risky Behavior, and Social standards amongst Pakistani University Undergraduates in Coronavirus disease-2019
Authors: Hussain Shahid , Rasheed Abdul 
Published: September 2022

Abstract
This research inspects even if the illusion of invulnerability in Coronavirus disease-2019 among persons raises uncertain behavior via questionnaire statistics of university undergraduates in Pakistan. We investigate whether members' illusion of invulnerability varies depending on their point of intimacy with other people. Research detected that the classmates' presence in the place of neighbourhoods/guests creates members with greater Coronavirus disease-2019 illusion of invulnerability disposed to take more threats. As well, it is observed that preventive behavioral standards tailed by members lessen uncertain behavior amongst members with the greater illusion of invulnerability. Our research results suggest significant inferences for officials to reduce the spread of the virus among university undergraduates.
Extraction of Avocado Peel Oil Using a Soxhlet Extractor and Investigation of Its Physicochemical Properties
Authors: Muleta Melkiyas Diriba , Daba Bulcha Jifara , Dube Abnet Mengesha , Ramesh R. 
Published: September 2022

Abstract
This study investigates the extraction of avocado peel oil from avocado peel using a soxhlet extractor at different extraction times, temperatures, and solvent to avocado peel ratios using hexane solvent. The time for extraction ranges from 2 to 5 h, the extraction temperature ranges from 60 to 70°C at a temperature deviation of ± 2°C, and the hexane to avocado peel ratio ranges from 4 to 5 ml/g. Thus, the study reveals that the maximum amount of 29.93% w/w avocado peel oil was extracted at 3 h of extraction, at the boiling point of hexane, and at a 5 ml/g of hexane to avocado peel ratio. For varying extraction temperatures at constant hexane to avocado peel ratio, the optimum avocado peel oil was obtained at 70 ± 2℃ extraction temperature and 4.5 h of extraction time. Finally, the obtained oil was characterized for its physicochemical properties, from which an acid value of 2.8 mg KOH/g of oil and a free fatty acid of 1.4% were obtained from the study.
Thousands of conductance levels in memristors monolithically integrated on CMOS
Authors: Yang Jianhua , Rao Mingyi , Tang Hao , Wu Jiang-Bin , Song Wenhao , Zhang Max , Yin Wenbo , Zhuo Ye , Kiani Fatemeh , Chen Benjamin , Liu Hefei , Chen Hung-Yu , Midya Rivu , Ye Fan , Jiang Hao , Wang Zhongrui , Wu Mingche , Hu Miao , Wang Han , Xia Qiangfei , Ge Glenn , Li Ju 
Published: September 2022

Abstract
Neural networks based on memristive devices have shown potential in substantially improving throughput and energy efficiency for machine learning and artificial intelligence, especially in edge applications. Because training a neural network model from scratch is very costly, it is impractical to do it individually on billions of memristive neural networks distributed at the edge. A practical approach would be to download the synaptic weights obtained from the cloud training and program them directly into memristors for the commercialization of edge applications. Some post-tuning in memristor conductance may follow afterward or during applications. Therefore, a critical requirement on memristors for neural network applications is a high-precision programming ability to guarantee uniform and accurate performance across a massive number of memristive networks. This translates into the requirement of many distinguishable conductance levels on each memristive device, not just lab-made devices but more importantly, devices fabricated in foundries. High precision memristors also benefit other neural network applications, such as training and scientific computing. Here we report over 2048 conductance levels, the largest number among all types of memories ever reported, achieved with memristors in fully integrated chips with 256x256 memristor arrays monolithically integrated on CMOS circuits in a standard foundry. We have unearthed the underlying physics that previously limited the number of achievable conductance levels in memristors and developed electrical operation protocols to circumvent such limitations. These results reveal insights into the fundamental understanding of the microscopic picture of memristive switching and provide approaches to enabling high-precision memristors for various applications.
Analysis of clinical characteristics, diagnosis and treatment status of hospitalized patients with chronic heart failure in Xinjiang,China
Authors: Abuduhalike Refukaiti , Abudouwayiti Aihaidan , Abuduhalike Kailibinuer , Nazimu Kamaliding , Sun Juan , Mahemuti Ailiman 
Published: September 2022

Abstract
Purpose
To investigate and analyze the demographic data, clinical characteristics, treatment and prognosis of hospitalized patients with chronic heart failure (CHF) in Xinjiang.
Methods
The data included in this study are the subgroup data from the Xinjiang of the China Heart Failure Center Registration Study. From January 1, 2018 to September 1, 2020, 7677 CHF patients who meet the CHF diagnostic criteria and have complete clinical data will be treated as the research objects. Collect selected demographic data, heart failure risk factors, heart failure etiology, laboratory and examination results, medication use and prognosis information.
Results
(1)The causes of CHF are: coronary atherosclerotic heart disease (65.57%), dilated cardiomyopathy (11.05%), hypertension (9.01%) and valvular heart disease (8.7%).༈2༉A total of 78 CHF patients (1.00%) died in the hospital during hospitalization. A total of 512 CHF deaths (6.8%) occurred within 12 months of discharge.༈3༉HFpEF patients are older, the proportion of women is the highest, and the proportion of patients with CHF comorbidities is the highest (P < 0.05).༈4༉Although there was no significant difference in the standardized medications of CHF in the provincial and municipal tertiary hospitals, the proportion of pacing intervention and coronary revascularization in the provincial tertiary hospitals was higher than that in the municipal tertiary hospitals (P < 0.05).
Conclusion
The main cause of CHF in Xinjiang is coronary heart disease, and patients with different types of CHF have different clinical characteristics. The mortality rate of CHF inside and outside the hospital is still high, and there is a certain gap between the treatment practice of CHF in Xinjiang and the treatment recommended by the guidelines. It is necessary to establish and improve a standardized, individualized, and standardized diagnosis and treatment system for CHF in Xinjiang.
Inhibiting PDPK1 and the phosphorylation of PDPK1(ser241) protect hepatocyte from Alcoholic steatohepatitis by promoting autophagy
Authors: Zhang Yuan , Ding Hao , Wang Hao , Zeng Le , Qian Zhenzhen , Huang Cheng 
Published: September 2022

Abstract
Health risk stemming from drinking alcohol is serious, sometimes even life-threatening. Alcoholic steatohepatitis (ASH) is a critical stage leading to cirrhosis and end-stage liver disease. However, its pathogenesis is still far from clearly understood and an effective treatment recognized widely haven’t been discovered. Interestingly, PDPK1, 3-phosphoinositide-dependent protein kinase 1, also known as PDK1, were observed obviously increased in ASH model by our researchers. Meanwhile, we also investigated the protective role of autophagy playing in ASH. Here, we studied the function of PDPK1 and found an efficient treatment to alleviate symptoms by targeting PDPK1 in ASH. In our study, PDPK1 affects hepatocyte self-healing by inhibiting autophagy. Both inhibiting PDPK1 and the phosphorylation of PDPK1(ser241) could protect hepatocyte from suffering heavy alcoholic hepatitis.
The Role of Political Belief in COVID-19 Vaccine Resistance,
Virus Transmission, and Closure Policy Response
Authors: Gabriel Stuart , Ben-Shahar Danny , Golan Roni 
Published: September 2022

Abstract
In this paper, we employ unique panel data on the universe of COVID-19 vaccination and infection cases in Israel to examine the role of political belief in COVID-19 vaccine uptake, virus transmission, and closure policy response. The paper identifies political belief based on statistical area votes in national elections held in Israel on the eve of the COVID-19 outbreak in March 2020. Unlike the U.S. and elsewhere, pandemic policy intervention in Israel was broadly supported by politicians across the belief spectrum; as such, household response to virus risk was not biased owing to partisan leadership disagreement and debate. Statistical findings show, all things equal, that in the wake of emergent and localized virus risk, politically right-of-center and religious voters display substantially higher odds of both vaccine resistance and virus transmission as compared to their left-center counterparts. Moreover, political belief is highly salient to aggregate pandemic outcomes. Model simulation shows that had all belief groups responded to virus risk with the more risk-averse behaviors of left-of-center voters, the number of vaccinations nationwide would have increased by 15 percent. That same scenario results in a full 30 percent reduction in total infection cases. Results also show that coercive policy measures such as economic closure were more effective in reducing virus transmission among less risk-averse right-wing and religious voters. Findings provide new evidence of the role of political belief in household response to health risk. Results further underscore the importance of timely, targeted messaging and treatment among divergent political belief groups so as to enhance COVID-19 policy efficacy and related disease control.
JEL Codes: I18, D91, D8, R1
Comparative transcriptome profiling of resistant and susceptible foxtail millet responses to Sclerospora graminicola infection
Authors: Wang He , Han Yanqing , Wu Caijuan , Zhang Baojun , Zhao Yaofei , Han Yuanhuai , Wang Jianming 
Published: September 2022

AbstractBackground:Downy mildew of foxtail millet, which is caused by the biotrophic oomycetesSclerospora graminicola(Sacc.) Schroeter, is one of the most disruptive diseases in foxtail millet. The foxtail millet-S. gramnicolainteraction is very poor and largely unexplored. Transcriptome sequencing technology is helpful to reveal the interaction mechanism between foxtail millet and pathogen.Results:In this study, Transmission electron microscopy observation of leaves infected byS. gramnicolashowed that the structures of organelles in the host cells were gradually deformed and damaged, or even disappeared from 3- to 7-leaf stages. However, organelles in leaves of resistant varieties were rarely damaged. Meanwhile, the activities of seven cell wall degrading enzymes in resistant and susceptible varieties were also quite different after pathogen induced. Subsequently, we have compared the transcriptional profiles between resistant G1 and high susceptible variety Jingu21 in response toS.graminicolainfection at 3, 5, 7 leave stages using the RNA-Seq technology. 473 and 1433 differentially expressed genes (DEGs) were identified in resistance and susceptible varieties, respectively. The pathway analysis of DEGs showed that the highly enriched categories were related to glutathione metabolism, plant hormone signaling, phenylalanine metabolism and cutin, suberine and wax biosynthetic. Some defence-related genes were also revealed in the DEGs, including leucine-rich protein kinase, Ser/Thr protein kinase, peroxidase, cell wall degrading enzymes, laccases and auxin response genes. Equally notable is that the pathyway of starch and sucrose metabolism was enrichment in three infected stages, most of the genes were specifically up-regulated at 5L in susceptible variety, indicating that the expression of genes might be beneficial to and promote the interaction between host and pathogen.Conclusions:Transcriptome sequencing was revealed that host resistance toS. graminicolawas likely due to the activation of defense related genes, such as leucine-rich protein kinase, Ser/Thr protein kinase, and alteration of signaling pathways related to hormome. Our study identified pathyway and genes were contributed to the understanding at transcriptomic level of the interaction between foxtail millet andS.graminicola.The results will help to better understand downy mildew of foxtail millet resistance mechanism againstS. graminicola.
Preclinical evaluation of safety and immunogenicity of a primary series intranasal COVID-19 vaccine candidate (BBV154), and humoral immunogenicity evaluation of a heterologous prime-boost strategy with COVAXIN (BBV152)
Authors: Sunagar Raju , Prasad Sai , vadrevu Krishna 
Published: September 2022

Abstract
Most if not all vaccine candidates developed to combat COVID-19 due to SARS-CoV-2 infection are administered parenterally. As SARS-CoV-2 is transmitted through infectious respiratory fluids, vaccine-induced mucosal immunity could provide an important contribution to control this pandemic. ChAd-SARS-CoV-2-S (BBV154), a replication-defective chimpanzee adenovirus (ChAd)-vectored intranasal (IN) COVID-19 vaccine candidate, encodes a prefusion-stabilized version of the SARS-CoV-2 spike protein containing two proline substitutions in the S2 subunit. We performed preclinical evaluations of BBV154 in mice, rats, hamsters and rabbits. Repeated dose toxicity studies presented excellent safety profiles in terms of pathology and biochemical analysis. IN administration of BBV154 elicited robust mucosal and systemic humoral immune responses coupled with cell-mediated immune responses dominated by Th1-like cytokine expression. Heterologous prime-boost vaccination with intramuscular (IM) COVAXIN-prime followed by BBV154 intranasal in rabbits elicited superior immune responses compared with the homologous COVAXIN/COVAXIN schedule. BBV154 is now being assessed in both homologous and heterologous combination schedules in ongoing human clinical trials.