bluuebunny/crossref_metadata_2025_split huggingface dataset:
INEFFECTIVE BREATHING PATTERN NURSING CARE WITH CHRONIC KIDNEY DISEASES PATIENT
Authors: Ilkafah Ilkafah , Fujiyah Eka Fatmah , Purwanto Cucuk Rahmadi , Susanto Joko , Lutfiandini Cherlys Tin 
Published: June 2022

Introduction: Patient with Chronic Kidney Disease (CKD) will get a failure to breathing because of fluid accumulation in the lung. Patients with CKD will not be able to breathe normally, so the main problem that often occurs is an ineffective breathing pattern. This study aims to explore nursing care for patients with ineffective-breathing pattern in patient with CKD at Soegiri Lamongan hospital. Methods: The design of this research is qualitative with a case study, the methods of data collection through interviews, observations, physical examinations and documentation studies. The data obtained were analyzed by comparing case reviews and literature reviews. Results: The results of the problems for nursing diagnosis that arise are CKD with ineefective-breathing pattern. Interventions that are emphasized and carried out in the field in the case study are providing a semi-fowler/ fowler position, and maintaining oxygen therapy. Final evaluation of nursing diagnoses in patients with problems resolved and goals achieved according to the specified time criteria. Conclusions: The study indicated that ineefective breathing pattern can be solved by positioning a semi-fowler or half-sitting position, decrease fluid intake and correcting anemia. Suggestions for nurses to focus in developing science and technology to be applied to all nursing personnel in providing nursing care for ineffective breathing patterns for patients with chronic kidney disease.
oxLDL-Induced Trained Immunity Is Dependent on Mitochondrial Metabolic Reprogramming
Authors: Groh Laszlo A. , Ferreira Anaisa V. , Helder Leonie , van der Heijden Charlotte D. C. C. , Novakovic Boris , van de Westerlo Els , Matzaraki Vasiliki , Moorlag Simone J. C. F. M. , de Bree L. Charlotte , Koeken Valerie A. C. M. , Mourits Vera P. , Keating Samuel T. , van Puffelen Jelmer H. , Hoischen Alexander , Joosten Leo A. B. , Netea Mihai G. , Koopman Werner J. H. , Riksen Niels P. 
Published: June 2022

Abstract
Following brief exposure to endogenous atherogenic particles, such as oxidized low-density lipoprotein (oxLDL), monocytes/macrophages can adopt a long-term pro-inflammatory phenotype, which is called trained immunity. This mechanism might contribute to the chronic low-grade inflammation that characterizes atherosclerosis. In this study, we aim to elucidate immunometabolic pathways that drive oxLDL-induced trained immunity. Primary isolated human monocytes were exposed to oxLDL for 24 h, and after five days stimulated with LPS to measure the cytokine production capacity. RNA-sequencing revealed broad increases in genes enriched in mitochondrial pathways after 24 h of oxLDL exposure. Further omics profiling of oxLDL-trained macrophages via intracellular metabolomics showed an enrichment for tricarboxylic acid (TCA) cycle metabolites. Single cell analysis revealed that oxLDL-trained macrophages contain larger mitochondria, potentially likely linked to increased oxidative phosphorylation (OXPHOS) activity. Co-incubation with pharmacological blockers of OXPHOS inhibited oxLDL-induced trained immunity. The relevance of OXPHOS was confirmed in a cohort of 243 healthy subjects showing that genetic variation in genes coding for enzymes relevant to OXPHOS correlated with the capacity of monocytes to be trained with oxLDL. Interestingly, OXPHOS appears to play an important role in the increased cytokine hyperresponsiveness by oxLDL-trained macrophages. The TCA-cycle can also be fuelled by glutamine and free fatty acids, and pharmacological blockade of these pathways could prevent oxLDL-induced trained immunity. This study demonstrates that the mitochondria of oxLDL-trained macrophages undergo changes to their function and form with OXPHOS being an important mechanism for trained immunity, which could unveil novel pharmacological targets to prevent atherogenesis.
Global Burden of Tuberculosis From 1990 to 2019
Authors: Chen Yuqian , Liu Jin , Zhang Qianqian , Wang Qingting , Chai Limin , Wang Yan , Li Danyang , Qiu Yuanjie , Chen Huan , Wang Jian , Xie Xinming , Li Manxiang 
Published: June 2022

Abstract
Background
Tuberculosis is the most pervasive infectious diseases worldwide. Studies examining the scope, variation and influence factor of the worldwide burden of tuberculosis are lacking.
Methods
In this cross-sectional study, epidemiologic data were gathered using the Global Health Data Exchange query tool, covering persons with tuberculosis in 204 countries and 21 regions from January 1, 1990, to December 31, 2019. We estimated the incidence and age-standardized rates (ASR) on tuberculosis by age, sex, region, and country. Annual percentage change (EAPC) was used to quantify the temporal trends of ASR. We also analyzed the incidence, mortality and variation trends and influence factor of tuberculosis including drug-susceptible and drug-resistant tuberculosis from 1990 to 2019.
Results
Globally, the incident cases of tuberculosis had decreased in most part of the world from 1990 to 2019, the age-standardized incidence rates (ASIR) decreased by an average 1.63% per year. Central and Southern Sub-Saharan Africa had the highest ASIR in 2019. Globally, the number of incidents mainly appeared in 20–24 years old individuals in both genders. Nearly half of all new cases of drug-susceptible tuberculosis (DS-TB) and multidrug-resistant tuberculosis without extensive drug resistance (MDR-TB) in 2019 came from South Asia, the proportion had already exceeded nearly 50% globally. By contrast, the most incident cases of extensively drug-resistant tuberculosis (XDR-TB) were found in Eastern Europe. As for various SDI quintiles, the high-middle SDI quintile had a highest ASIR in XDR-TB. As for morality and DALYs, South Asia had the most deaths and DALYs. The change trends of ASDR (age-standardized deaths rate) and age-standardized DALYs rate for DS-TB, MDR-TB and XDR-TB among SDI quintiles showed the same pattern as that in ASIR. We also found an overall inverse association between the ASIR of tuberculosis (and the proportion of drug-resistant tuberculosis) and SDI at the regional level.
Conclusion
Tuberculosis remained the leading cause of death from an infectious disease worldwide, and the increasing proportion of drug-resistant tuberculosis was of equal concern. The observed regional patterns varied widely, and the geographic disparities may provide support for tuberculosis health care planning and resource allocation.
Microplastics Isolated From Shellfish Paratapes undulatus From Kuala Selangor, Selangor, Malaysia
Authors: Mazlan Nurzafirah , Shukhairi Sarah Syazwani , Husin Miftahul Jannah Muhammad , Shalom Jemimah , Saud Safaa Najah , Sani Muhammad Shirwan Abdullah , Chuan Ong Meng , Mohan Naveen Kumar Naidu Chandra 
Published: June 2022

Abstract
Due to constant large-scale production and poor management, plastic litter have been creating serious environmental issue in recent years. These microplastics with a diameter of 5 mm and 1 µm enter the marine ecosystem and were easily ingested by marine animals which are later consumed by humans in the form of seafood. The goal of this study was to determine the types of microplastics that can be found in Paratapes undulatus in Kuala Selangor, Malaysia. A total of 30 P. undulatus samples were collected from Kuala Selangor and soft tissue were dissected and digested using NaOH. The digestate was then vacuum filtered using vacuum pump in order to obtain the microplastics. Microplastics were identified based on its physical characteristics under microscopic examination (colour, shape and size). FTIR was used to examine the functional groups of microplastics to determine the type of polymers. P. undulatus had a total of 2072 microplastics. In terms of colors and shapes, the majority of microplastics detected were black (64.48%) and fibres (97.2%). The largest abundance was found in the size ranges within 0.5 to 1 µm and 1 to 2 µm. Polystyrene (PS) and polymethyl methacrylate (PMMA) were two microplastics polymers found. As a result, microplastics were successfully identified from P. undulatus, indicating the presence of microplastics pollution in the marine ecology. More research can be done on the toxicity and potential threats of microplastics to human when consumed as seafood.
Nonlinear Dyn manuscript No. (will be inserted by the editor)
Trajectory design with finite time properties in precision positioning maneuvers
Authors: Ibarra Efraín , Manzanilla Adrian , Castillo Pedro , Chapa Ricardo 
Published: June 2022

Abstract
In this paper is presented a new technique to design trajectories with finite time convergence properties for precision tracking maneuvers in unmanned vehicles. This technique allows the finite time positioning on sequentially distributed points, the properties for the trajectory guarantee to start in an initial point with velocity and acceleration zero, and position itself on the subsequent point with finite time convergence, again with velocity and acceleration zero. Such trajectory depends exclusively of the time and of the initial and last position. In addition, this technique could be used to design open loop controllers to be implemented in mobile robotics applications that require long accuracy. To show the controllers feasibility we considering the kinematic car model with finite time properties, obtaining an open loop control for the car’s velocity and steering the vehicle to desired trajectory, where simulation results present the control performance and effectiveness.
Effect of organosilicon resin containing disulfide bonds on elastic properties of cotton fabric
Authors: Wang Rong , Deng shuang , Cao Lixia , Liu Yanmei , Yang Wenyu , Min Jie , Fang Jin 
Published: June 2022

Abstract
Cotton fabrics are popular for their excellent properties, but their property of creasing easily largely limits the wide application of cotton fabrics. In this paper, an organosilicon resin emulsion containing disulfide bonds was prepared with epoxy-terminated silicone oil and 4,4-diaminodiphenyldisulfide (AFD) as raw materials, and it was used as a finishing agent for the elastic finishing of cotton fabrics. The effects of raw material ratio on the elastic properties of organosilicon polymer film and the effects of emulsifier dosage and emulsification time of emulsion polymerization on the properties of organosilicon resin emulsion were studied. In addition, the effects of organosilicon finishing agent dosage, baking temperature, and baking time on the elastic properties of cotton fabric were also studied. The research results show that the average particle size of the prepared organosilicon resin emulsion is about 250 nm, the particle size distribution is concentrated and the emulsion is stable. The delayed elastic recovery angle of the cotton fabric treated with an organosilicon finishing agent can reach 185°, showing excellent high delayed elasticity. At the same time, it was found that the finished cotton fabric exhibited an excellent and special temperature-responsive shape memory function based on the existence of disulfide bonds in the organosilicon polymer network structure.
High-frequency S and S-coda waves at ocean-bottom seismometers
Authors: Takemura Shunsuke , Emoto Kentato , Yamaya Lina 
Published: June 2022

Abstract
To clarify the characteristics of high-frequency (> 1 Hz) S and S-coda waves at ocean-bottom seismometers (OBSs), we analyzed seismograms observed at permanent OBSs and inland broadband seismometers around the Kii Peninsula in southwest Japan along the Nankai Trough. The coda amplitudes (both horizontal and vertical) at the OBSs were much larger than those at the inland rock-site stations. Because coda amplitudes relative to those at inland rock-site stations have been used as site-amplification factors, large site amplifications for both components can be expected due to the presence of thick oceanic sediments just below the OBSs; however, the observed maximum S-wave amplitudes in the vertical component exhibited similar attenuation trends against epicentral distances at both OBS and inland stations. To clarify the causes of this discrepancy, we conducted numerical simulations of seismic wave propagation using various three-dimensional seismic velocity structure models. The results demonstrated that coda waves at OBSs mostly comprise multiple scattered waves within a thick (> 2 km) sedimentary layer; consequently, coda amplitudes at OBSs become much larger than those at inland rock-site stations. However, the thick sedimentary layer has limited effects on maximum S-wave amplitudes at the OBSs. Given that the effects of a thick sedimentary layer on S and S-coda waves differ, we concluded that the coda-normalization technique for site-amplification correction cannot be applied if stations are located within regions above the thick sedimentary layer. The site amplifications at the OBSs were corrected according to the horizontal-to-vertical ratios at each OBS; we adjusted the simulated horizontal envelopes at the OBSs using these ratios of the observed S-coda waves, resulting in simulation results practically reproducing the observed high-frequency envelopes at OBSs.
Use of a Chalazion Clamp for Excision of the Eyelid Margin Lesion: A Novel Technique
Authors: He Jinjing , Jiang Jin , Bao Lulu , Gong Jingwen 
Published: June 2022

Abstract
Background
Reconstruction after eyelid lesion excision is very important. It calls for preserving normal eyelid function for the protection of the eye and restoring good cosmesis. It is important to precisely align the tarsal plate. However, the unique anatomy of eyelids often makes hemostasis difficult and surgical field obscured. We report an effective method to solve this problem.
Method
This retrospective study included 25 patients who had undergone eyelid margin lesion excision using the chalazion clamp between March 2020 and October 2021. The chalazion clamp is placed on the desired location and tightened, providing a bloodless field for eyelid lesion removal. Without bleeding, visibility of the cut edges is improved considerably. It makes anatomical anastomosis of the tarsal plate easier.
Results
All of the 25 patients preserve normal eyelid function and restore good cosmesis, without recurrence during the follow-up period.
Conclusion
The use of the chalazion clamp during excision of the eyelid margin lesion could stabilizes the eyelid, protects the eyeball from accidental injuryand, and provides a clear bloodless operative field. It can ensure the neatness of the cut edges and offer better incision alignment for suture. It also avoids wasting too much time on hemostasis, without additional expensive equipment.
Role of Echocardiography in the Assessment of Cardiac Involvement in Takayasu Arteritis
Authors: Fu Jiarong , Liu Jinfeng , Li Xiaoming , Wu Shan , Yu Huimei , Zhang Chun 
Published: June 2022

Abstract
The aim of this study is to investigate echocardiographic features of patients with cardiac involvement and evaluate the value of echocardiography in Takayasu arteritis (TA). This retrospective study compared the clinical manifestations and echocardiographic parameters of 127 TA patients with and without cardiac involvement and further explored the relationship between pulmonary hypertension (PH) and echocardiographic parameters. Clinical, imaging and laboratory results of the TA patients were obtained from hospital files. In our study, 68 patients (53.54%) had cardiac involvement. Valvular abnormalities were found in 55 (80.88%) patients in the heart involvement group, coronary artery abnormalities in 10 (14.71%), myocardial abnormalities in 18 (26.47%) and heart failure in 10 patients (14.71%), respectively. Among TA patients with cardiac involvement, PH was detected in 11 patients (16.18%) with echocardiographic assessment. Compared to the control group, both the TA patients with cardiac involvement associated with and without PH presented with the significantly differences of echocardiographic parameters regarding LAD, IVST, LVPWT, LVEDD, LVESD, LVEF, LV mass, LV mass/BSA, MPAD and E peak (P < 0.05). Compared the echocardiographic parameters between the patients with and without PH of TA patients with cardiac involvement, the differences were of no statistical significance (P > 0.05). Cardiac involvement is not infrequent in TA patients and it should be carefully evaluated. Echocardiography plays a vital role in the assessment of cardiac involvement in TA which is helpful for diagnosis and management of TA.
Co-circulation of multiple genotypes of ARV in poultry in Anhui, China
Authors: Jiang Xiaoning , Tang Yi , Diao Youxiang 
Published: June 2022

Abstract
Background: Poultry production in China has been experiencing a high incidence of broiler arthritis /tenosynovitis caused by avian orthoreovirus (ARV) since 2013. In the spring of 2020 severe arthritis cases from broiler flocks were identified in large-scale commercial poultry company in Anhui Province, China. Methods: Diseased organ from dead birds were sent for diagnosis to our laboratory. ARV, including seven broiler-isolates and two breeder-isolates, was successfully harvested and sequenced. Results: Interestingly, the genotypes of ARVs isolated from infected chickens were inconsistent between different flocks or even between different houses on the same flocks. Subsequently, a total of 89.66 per cent sera samples collected from apparently healthy adult broiler flocks unvaccinated against ARV tested positive for ARV antibodies, suggesting that low and high virulence reovirus strains may be co-circulating in the farm. To this end, we collected unhatched embryos from breeders (parental generation) for pathogen tracing, the two harvested ARV breeder-isolates indicated that the factor of vertical transmission from breeders to progeny should not be underestimated for the prevalence of ARV within broiler flocks. Conclusion: The findings have implications for evidenced-based formulation of prevention and control strategies.
Body mass index-associated lncRNAs and their roles in lung cancer
Authors: Fu Xiaoying , Huang Qinmiao , Lin Yancheng , Ling Lin , Ho Kuoting 
Published: June 2022

Abstract
Background:
Obesity often increases the risk of cancer and worsens the prognosis. Unlike most types of cancer, obesity and lung cancer displayed a mixed relationship. Several studies concluded that obesity had an inverse impact on incidents of lung cancer and benefited the overall survival, with few underlying mechanisms understood. Obesity-related and adipocytes-derived lncRNAs had been reported to deregulate the cancer-associated pathways. Here we conducted this study to identify the potential BMI-associated lncRNAs and their roles in lung cancer.
Methods:
We identified the BMI-associated lncRNAs from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) lung study, with additional analyses of their relationship with lung cancer, impact on overall survival, and potential pathways involved. In addition, we carried out the validation in local peripheral blood samples from 4 groups, including healthy, obese, lung cancer patients with obesity, and lung cancer patients with normal BMI.
Results:
We identified four BMI-associated lncRNAs which potentially impacting tumor progression and cancer survival. MTORC1 and MYC were among the top pathways enriched from these lncRNAs. We further validated that TM4SF19-AS1 showed a significant difference between lung cancer patients with obesity and with normal BMI in peripheral blood.
Conclusions:
Our findings suggested that BMI-associated lncRNAs could potentially regulate cancer-related pathways and immune response in lung cancer. The lncRNA validated in peripheral blood could serve as biomarkers to monitor cancer progression.
Impact of nicotinamide mononucleotide (NMN) and platelet rich fibrin (PRF) on senescence in spontaneously aging and irradiated human osteoblasts
Authors: Hakim Samer G. , Gracht Anij , Pries Ralph , Rades Dirk , Steller Daniel 
Published: June 2022

Abstract
With the increasing human lifespan, bone aging and related pathologies increasingly contribute to the musculo-skelettal homeostasis, and senescence related osteoblasts disorders are supposed to play a key role in osteoporosis, osteonecrosis and bone remodeling diseases. Only limited studies have elucidated the histomorphological and molecular changes in senescent human osteoblasts (OBs) and their potential treatment.In the present study we investigated the cellular changes induced by spontaneous inherent as well as radiation-induced senescence in OBs and the impact of addition cultivation with nicotinamide mononucleotide (NMN) and platelet rich fibrin (PRF) on apoptosis, senescence-associated β-galactosidase staining and senescence related gene expression using RT2 Profiler PCR array. We found that OBs alteration through spontaneous inherent aging follows a different pathway than that of radiation-induced cellular senescence. Both NMN and PRF seem to provide a senescence and radioprotective effect on human OBs, albeit by different mechanisms. These results provide evidence on the potential clinical implication of systematic NMN administration and local PRF application to prevent age-related bone disturbance in elderly patients.
Observation of a robust and highly active catalyst for water electrolysis under the current density of 1000 mA cm-2
Authors: Zhang Yudi , Arpino Kathryn , Yang Qun , Kikugawa Naoki , Sokolov Dmitry , Hicks Clifford , Liu Jian , Felser Claudia , Li Guowei 
Published: June 2022

Abstract
Despite the fruitful achievements in the development of hydrogen production catalysts with record-breaking performances, there is still a lack of durable catalysts that could work under large current densities (> 1000 mA cm− 2). In the context of this need, we investigated the catalytic behaviors of Sr2RuO4 (SRO) bulk single crystals with well-defined surface crystal structures, which is a benchmark material to explore exotic metallic states and electronic structures. This single crystal has demonstrated remarkable activities under the current density of 1000 mA cm− 2, which require overpotentials of 182 and 278 mV in 0.5 M H2SO4 and 1 M KOH electrolytes, respectively, after ohmic correction. These values slightly increased to 272 and 354 mV even without iR correction, exhibiting high potential for industrial-scale hydrogen production. The high performance is also evidenced by the 56 days of continuous testing at a high current density of above 1000 mA cm− 2 and then under operating temperatures of 70 ℃ for alkaline electrolysis. The in-situ formation of ferromagnetic Ru clusters at the crystal surface is critical for the outstanding catalytic activity, endowing the single-crystal catalyst with low charge transfer resistance and high wettability for rapid gas bubble removal. Density functional theory calculations indicate that SRO gains electrons from the Ru clusters, thus leading to the thermodynamically favorable hydrogen desorption for the rapidly modified catalysts. More generally, our experiment exemplifies the potential of designing novel HER catalysts that work under industrial-scale current density.