bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of KLF6 reduces the inflammation and apoptosis of type II alveolar epithelial cells in acute lung injury
Authors: Chen Qingbin , Jia Zhen , Qu Changjing 
Published: September 2022

Background: The development of acute lung injury (ALI) into a severe stage leads to acute respiratory distress syndrome (ARDS). The morbidity and mortality of ALI and ARDS are very high. Objective: This study is aimed to explore the effect of Krüppel-like factor 6 (KLF6) on lipopolysaccharide (LPS)-induced type II alveolar epithelial cells in ALI by interacting with cysteine-rich angiogenic inducer 61 (CYR61).
Material and Methods: ALI mice model and LPS-induced type II alveolar epithelial cells were conducted to simulate ALI in vivo and in vitro. The messenger RNA (mRNA) and protein expression of KLF6 in lung tissues were detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blot analysis. Pathological changes in lung tissues were observed by hematoxylin and eosin (H&E) staining. The viability and KLF6 expression of A549 cells treated with different concentrations of LPS were detected by cell counting kit-8 (CCK-8) assay, RT-qPCR, and Western blot analysis. After indicated treatment, the viability and apoptosis of A549 cells were analyzed by CCK-8 and TUNEL assays, and the inflammation factors of A549 cells were detected by Enzyme-linked-immunosorbent serologic assay, RT-qPCR, and Western blot analysis. The combination of KLF6 and CYR61 was determined by chromatin immunoprecipitation (ChIP)-PCR and dual-luciferase reporter assay.
Results: KLF6 expression was increased in lung tissues of ALI mice and LPS-induced A549 cells. Interference with KLF6 improved the viability, reduced the inflammatory damage, and promoted the apoptosis of LPS-induced A549 cells. In addition, KLF6 could bind to CYR61. Interference with KLF6 could decrease CYR61 expression in LPS-induced A549 cells. LPS also enhanced the TLR4/MYD88 signaling pathway, which was reversed by KLF6 interference. The above phenomena in LPS-induced A549 cells transfected with Si-KLF6 could be reversed by overexpression of CYR61.
Conclusion: Inhibition of KLF6 promoted the viability and reduced the inflammation and apoptosis of LPS-induced A549 cells, which was reversed by CYR61.
Shape Dynamic Time Warping for Seismic Waveform Inversion
Authors: Tan Jiayan , Langston Charles A. 
Published: September 2022

ABSTRACT
We illustrate shape dynamic time warping (ShapeDTW) for 1D structure waveform inversion with examples from Tanzania, East Africa, and Northeastern Oklahoma. Seismograms of the Mw 5.9 Lake Rukwa, Tanzania, earthquake (18 August 1994) recorded by regional broadband seismographic stations of the Tanzania Broadband Seismic Experiment are used to demonstrate the method. We also test the inversion through solving for 1D crustal velocity structure of the Cherokee Platform in Oklahoma using seismograms of the 2011 Mw 5.7 Prague, Oklahoma, earthquake recorded by the EarthScope Transportable Array. Dynamic time warping (DTW) bypasses the time expense required for manual identification of seismic phases and shows potential for linking discrete seismic phases between two similar waveforms. ShapeDTW improves inversion performance by characterizing the character of the time series near each amplitude point. Applying Sakoe-Chiba band limits to ShapeDTW and an additional amplitude constraint improves the overfitting problem that occurs with the classic DTW method. We apply ShapeDTW to estimate optimal time shifts between observed and synthetic waveforms with time shifts reduced through inversion. The crustal velocity model of Tanzania found using ShapeDTW is close to that found using “phase time inversion” of numerous regional seismic phases observed in the three-component waveforms in a previous study but avoids the necessity of isolating and interpreting different seismic phases in the waveforms. Reducing the ShapeDTW functional misfits can overcome the cycle-skipping problem that often occurs with direct comparison of amplitudes in waveform inversion. This method may be useful in generating starting models for other 1D and 3D inversion methods.
Opportunities and Challenges Regarding the Development of the Administrative Capacity from Romania. The European Integration and the Influence on the Elaboration Process of the Public Policies
Authors: Tascu-Stavre Miroslav 
Published: September 2022

The present paper aims to capture the manner in which the public administration of Romania evolved during the post-communist transition period. Likewise, this approach intends to identify the challenges and the opportunities associated with the adaptation and increase of the Romanian administrative capacity in the context of the adhesion to the European Union.
The aim of these changes was the shift from a controlled, political administration to a democratic one. As we will observe, the institutionalization of the formulation, implementation and evaluation systems of public policies in Romania is directly linked to the efforts of integration in the European Union and, implicitly, to the reform of the administrative system.
The hypothesis that we support is the following – the development of the administrative capacity and the reform of the public system was stimulated from outside the central administration and under the pressure of the obligations arising from the status of a Member State of the European Union.
Unfortunately, in Romania, despite the changes made at central levels, the reform of the administration has not brought an improvement in the planning or implementing of the policies.
In terms of policy evaluation, things do not seem to be any better, the culture of evaluation, the satisfaction of the public interest or the improvement of the activity remaining the exception rather than the rule, despite the constant support provided by European-funded programs
Usefulness of Thoracic Ultrasound with an Image Processing Method in The Diagnosis of Silicosis Disease
Authors: UZUNGET Sinan Cem , ERTÜRK Zamir Kemal , BARAN Tarık , UZUNGET Sezen 
Published: September 2022

Abstract:
The diagnosis of Silicosis Disease is based on regular follow-up, including physical examination, anamnesis and imaging methods, chest radiography and high resolution computed tomography (HRCT) which are the main imaging modalities shaped by universal guidelines. Due to its advantages such as rapid results, non-invasiveness, less cost of the procedure and radiation safety, thoracic ultrasound is an imaging method that can be utilized in the diagnosis of lung consolidation and alveolar-interstitial diseases and is preferred progressively.
Aims:
The thoracic ultrasound may accelerate the diagnostic process, with unbiased measurements, and contribute to control the disease progression by providing early diagnosis for patients with silicosis.
Methods:
We enrolled 34 patients with silicosis who had 1/0 or more involvement in chest radiography according to the ILO Pneumoconiosis reading score and age-matched 16 healthy volunteers. Then, pleural thickness, diaphragmatic thickness, pleural plaque, B line evaluated by thoracic ultrasound and the number of hyperechoic nodules that obtained from image processing by ImageJ Software.
Results :
There were no B lines in any study groups. Moreover, the pleural and diaphragmatic thicknesses and were not different between groups.
Conclusion
It was not accomplished to convert nodular structures in the thorax ultrasound into visible graphics by the image processing method, apart from a few exceptional cases
Detection and Characterization of β​-lactamases and Biofilm-producing Escherichia coli and Klebsiella pneumoniae from Ducks and Duck Environments in West Bengal
Authors: Mondal Tousif , Batabyal Kunal , Dey Samir , Joardar Siddhartha Narayan , Samanta Indranil , Isore Devi Prasad , Samanta Soumen , Paul Aditya 
Published: September 2022

Background: Escherichia coli and Klebsiella pneumoniae are two important commensals with pathogenic potentiality in animals and birds, causing intestinal and extra-intestinal infections. These are somewhat zoonotic too via different routes. So, the present study was undertaken to investigate the prevalence of these two bacteria from cloaca and environment of ducks from different districts of West Bengal, followed by detailed characterization and antibiogram. Methods: Around 197 duck and environmental samples were collected from different districts of West Bengal. E. coli and K. pneumoniae were isolated from collected samples as per standard methods followed by serotyping of the E. coli isolates. The detection of ESBL/ACBL producing isolates was done both phenotypically and genotypically by detecting the presence of antibiotic-resistant genes. Virulence property and biofilm-producing ability of these isolates were also studied. Antibiogram of the ESBL and biofilm positive isolates were done using common 12 antibiotics by disc diffusion method. Result: A total of 134(68.02%) Escherichia coli and 33(16.75%) Klebsiella pneumoniae isolates were recovered and confirmed by PCR. The prevalence of E. coli and K. pneumoniae in cloacal swabs were less in comparison to the environmental samples (72.09% and 20.93%). Approx. 79.85% E. coli and 72.73% K. pneumoniae isolates were found to be the ESBL/ACBL producers in vitro. E. coli and K. pneumoniae isolates possessed all major antibiotic-resistant genes with the blaAmpC (64.18% and 48.48%) being the most prevalent one. Twenty three (17.16%) E. coli isolates were found positive for the virulence genes, of which stx1 (39.13%) was the most common one as detected by multiplex PCR. No virulence gene was found in K. pneumoniae isolates. Ninety one (67.91%) E. coli and 26(78.79%) K. pneumoniae isolates possessed the biofilm-producing genes. All the ESBL and biofilms producing E. coli and K. pneumoniae isolates showed 100% - 95.24% resistance to ampicillin. A high percentage of resistances were also seen against cefotaxime, ticarcillin/ clavulanic acid, ertapenem, ceftazidime, norfloxacin and ciprofloxacin, which may be due to several reasons. Maximum overall sensitivity was detected against chloramphenicol, co-trimoxazole and gentamicin.
PENGUATAN MODAL USAHA PADA KOMUNITAS PELAKU USAHA KULINER DI KARANGANYAR MELALUI LEMBAGA KEUANGAN MIKRO (LKM) [STRENGTHENING BUSINESS CAPITAL OF CULINARY BUSINESS COMMUNITIES IN KARANGANYAR THROUGH MICRO FINANCIAL INSTITUTIONS (MFIS)]
Authors: Ahmad Ana Shohibul Manshur Al , Atmaji Atmaji , Sarjiyanto Sarjiyanto , Sunaryo Sinto 
Published: September 2022

<p align="justify"><em>The purpose of this community service is empowerment and efforts to maintain business sustainability in the culinary business community in Cangakan Karanganyar. Partners in this program are the culinary business community in Cangakan, Karanganyar, who have joined the KUBE (Business Community Group) institution. The main problem faced by partners is the aspect of capital, most of the members of KUBE Culinary Cangakan are street culinary traders so that prospective creditors are considered not bankable. In financial terms, this business actually has the potential to develop. The method used to solve the problem is assisting the establishment of a Micro Finance Institution (MFIs), as well as empowering community members through financial management and managerial training. The end result of this program is the formation of a healthy Micro Finance Institution from the culinary business community in Cangakan Karanganyar. Through the established Micro Finance Institution (MFIs), it is hoped that it can be a solution in overcoming working capital problems and business sustainability.</em> </p><p align="justify"><strong>BAHASA INDONESIA ABSTRACT: </strong>Tujuan pengabdian ini adalah pemberdayaan dan upaya menjaga keberlanjutan usaha pada komunitas pelaku usaha kuliner di Cangakan Karangnyar. Mitra dalam dalam program ini adalah komunitas pelaku usaha kuliner di Cangakan, Karangnyar yang sudah tergabung dalam kelembagaan KUBE (Kelompok Usaha Bersama). Permasalahan utama yang dihadapi oleh Mitra yaitu aspek permodalan, sebagian besar anggota KUBE Kuliner Cangakan adalah pedagang kuliner kaki-lima sehingga dipandang not-bankable oleh calaon kreditur. Secara financial sebetulnya usaha ini memiliki potensi untuk berkembang. Metode yang dipakai untuk menyelesaikan masalah adalah pendampingan pembentukan kelembagaan Lembaga Keuangan Mikro (LKM), sekaligus pemberdayaan anggota komunitas melalui pelatihan manajemen keuangan dan manajerial. Hasil akhir dari program ini adalah terbentuknya Lembaga Keuangan Mikro yang sehat dari komunitas pelaku usaha kuliner di Cangakan Karangnyar. Melalui Lembaga Keuangan Mikro (LKM) yang terbentuk diharapkan dapat menjadi solusi dalam mengatasi permasalahan modal kerja dan keberlanjutan usaha.</p>
PENINGKATAN KOMPETENSI GURU MELALUI PEMANFAATAN TEKNOLOGI INFORMASI [TEACHER COMPETENCE ENHANCEMENT THROUGH USE OF INFORMATION TECHNOLOGY]
Authors: Jayanti Ni Ketut Dewi Ari , Sastrawangsa Gde , Putri Ni Made Dewi Kansa 
Published: September 2022

<p><em>During the COVID-19 pandemic, teaching and learning activities in Indonesia, from basic education to university levels, must be carried out online. The main problem experienced by teachers in online teaching and learning activities is the lack of mastery of technology by teachers. Based on this, it is necessary to conduct mentoring and training programs to improve the ability of teachers to use technology to support online teaching and learning activities. For this reason, in this community service activity, training has been carried out which aims to provide knowledge to teachers to improve teacher competence using information technology. The method of implementing activities is through counseling and training. Activities have been evaluated using a questionnaire, the results achieved are 90.77% of teachers can use information technology to support online teaching and learning activities.</em></p><p> </p><p><strong>BAHASA INDONESIA ABSTRACT: </strong>Pada masa pandemi COVID-19 kegiatan belajar mengajar di Indonesia, mulai dari tingkat pendidikan dasar hingga perguruan tinggi harus dilaksanakan secara daring. Permasalahan utama yang dialami oleh guru dalam kegiatan belajar mengajar daring adalah kurangnya penguasaan teknologi oleh guru. Berdasarkan hal tersebut, perlu dilakukan program pendampingan dan pelatihan untuk meningkatkan kemampuan guru-guru dalam menggunakan teknologi guna mendukung kegiatan belajar mengajar daring. Untuk itu, pada kegiatan pengabdian masyarakat ini telah dilakukan pelatihan yang bertujuan memberikan pengetahuan kepada guru-guru untuk meningkatkan kompetensi guru melalui pemanfaatan teknologi informasi. Metode pelaksanaan kegiatan melalui penyuluhan dan pelatihan. Kegiatan telah dievaluasi dengan menggunakan kuesioner, hasil yang dicapai adalah 90.77% guru dapat menggunakan teknologi informasi dalam mendukung kegiatan belajar mengajar daring.</p>
COVID-19 DAN DAMPAKNYA BAGI PERILAKU KONSUMEN DI INDONESIA TAHUN 2021 [COVID 19 AND THE IMPACT TO CONSUMER BEHAVIOR IN INDONESIA IN 2021]
Authors: Sonny Sonny , Genoveva Genoveva , Chairy Chairy , Adinugroho Widyanto Hanif , Purnama Manurung Siska 
Published: September 2022

<p>This Community Service is organized by the Marketing Study Center (PUSKA) of President University to the public through a webinar (online). The purpose of this PKM is to provide guidance to business practitioners and the public, how to behave in the midst of this pandemic, product sales are decreasing from month to month, government regulations prohibiting people from leaving their homes temporarily, and public panic. Having business practitioners invited to be speakers, who also experienced the same decline but managed to bring their product sales back to normal, gave a lot of enlightenment to the people who attended the webinar.</p><p><em><strong>BAHASA INDONESIA ABSTRACT</strong>: PKM ini diselenggarakan oleh pusat kajian (PUSKA) marketing universitas Presiden kepada masyarakat melalui webinar (online). Tujuan dari PKM ini adalah memberikan pengarahan kepada praktisi bisnis dan masyarakat, bagaimana harus bersikap di tengah pandemik ini, dimana penjualan produk menurun dari bulan ke bulan, aturan pemerintah yang melarang masyarakat untuk keluar dari rumah sementara waktu, serta kepanikan masyarakat. Dengan adanya praktisi bisnis yang diundang menjadi pembicara, yang juga mengalami penurunan yang sama namun berhasil membuat penjualan produknya kembali normal, memberikan banyak pencerahan kepada para masyarakat yang hadir di webinar. </em></p>
La collaboration intersectorielle au service des compétences informationnelles : L’exemple d’un programme de formation à l’École des sciences de la gestion de l’Université du Québec à Montréal
Authors: Robert Édith , Castonguay Rémi , Méthé Alexandre , Trolliet Sophie 
Published: September 2022

Les bibliothécaires universitaires doivent composer avec plusieurs impératifs afin d’offrir de la formation sur les compétences informationnelles. L’objectif de ce texte est de partager notre expérience de travail d’équipe intersectorielle composée de membres du corps professoral, de bibliothécaires, de conseillères et conseillers technopédagogiques et d’intégration multimédia. En mettant nos expertises diverses à contribution, nous avons créé un parcours de formation des compétences informationnelles destiné aux étudiantes et étudiants d’un programme de deuxième cycle en sciences de la gestion. Ce projet novateur de l’Université du Québec à Montréal (UQAM) a été officiellement lancé en janvier 2022. Les étudiants acceptés à la maîtrise en sciences de la gestion devront obligatoirement réussir ce parcours de formation qui les initiera, d’une part, aux compétences informationnelles et numériques et, d’autre part, à différents principes de la communication savante et de l’intégrité intellectuelle. Les étapes ayant permis l’émergence de ce projet seront détaillées, de même que les défis rencontrés jusqu’à son achèvement.
Cette expérience pourrait inspirer d’autres établissements d’enseignement, mais nous cherchons surtout à montrer l’importance du travail intersectoriel pour accompagner les étudiantes et les étudiants vers leur réussite scolaire. Nous avons la conviction que plusieurs notions présentées dans le parcours de formation développé sont transversales, qu’elles dépassent la stricte maîtrise de compétences techniques nécessaires aux apprentissages et qu’elles jettent plus largement les bases d’une meilleure compréhension de l’univers numérique dans lequel les étudiants évoluent. Ne s’inscrivant pas directement dans le Plan d’action numérique du ministère de l’Éducation et de l’Enseignement supérieur du Québec (2018), des initiatives telles que celle menée par l’équipe de l’UQAM sont tout de même en cohérence avec plusieurs de ses orientations, dont la première, qui est de soutenir le développement des compétences numériques des jeunes et des adultes pour qu’ils soient des citoyens et des professionnels mieux informés.
Computational Study of Miniature Tube for Biomedical Application
Authors: ANSARI ZEYAULLAH , Pallekonda Ramesh Babu 
Published: September 2022

Abstract
Needle-free injection devices are novel inventions to provide medications to patients without puncturing their skin with a needle. The present work focuses on the computational study of fluid flow characteristics inside the shock tube designed for liquid-type drug delivery and also evaluates these computational and analytical results with experimental observations. To observe primary and reflected shock pressure and shock Mach number for achieving the controlled microjet velocity to accelerate the drugs. ANSYS fluent has been utilized to solve the governing equations of energy, continuity, and momentum where density-based implicit solver is used to perform the transient analysis of the shock tube. Two combinations of gases (nitrogen-air and helium-air as a driver and driven section gas) have been considered for the CFD analysis. Four pressures ranging from 25-50 bar in the driver section and 1 bar in the driven area are considered as an initial condition to perform the simulations. The obtained results showed that the pressure and temperature ratios and Mach numbers are more significant for the helium-air model than for the nitrogen-air model at different operating pressures. These results are validated using analytical calculations, which also agree well with experimental results. Further, the microjet velocity has been calculated. The maximum value of microjet velocity for the nitrogen-air model is 62 m/s, whereas for the helium-air model is 106 m/s. The microjet velocity is more significant for the helium-air combination; hence the penetration depth on the target surface will be more effective on helium than nitrogen.
Resource Efficiency and Economic Efficiency of Fish Farms in the South East of Côte d’Ivoire
Authors: Aboua Christian Angui 
Published: September 2022

Abstract
Fish farming is considered as a complement to fish production in Côte d’Ivoire. Better use of resources in the production process would ensure sustainable fish production. This study analyzes the resource efficiency and economic efficiency of 32 fish farms in the South East of Côte d’Ivoire using Data Envelopment Analysis (DEA) model and Cost-Benefit Analysis. The results revealed that fish farmers showed a low performance with an average technical efficiency score of 0.738 (CRS) and 0.575 (SBM) and an average economic score of 0.553. Fish farmers using industrial feed are the most technically and economically efficient. Through DEA model scenarios, the study shows that fish farmers generated excesses in resource utilization causing a shortfall in output. The scenario-3 based on slacked-based model minimizing resources simultaneously with a maximization of output indicated that a reduction of excesses in resources would have increased the output of 16.18%. Finally, the cost benefit analysis shows that, overall, fish farms achieved a positive gross and net profit margin. This study suggests that policy actors should play an important role in facilitating fish farmers’ access to feed and quality fingerlings. In addition, fish farmers must be trained on good practices for sustainable production and pond management.
Association between the distal tibiofibular syndesmosis types and ankle osteoarthritis in Chinese population: a retrospective study
Authors: Huang Lei , Zhang Xiaohong , Yang Siyi , Qing Jiwen , Wu Wangyu , Li Minghui , You Guixuan , Wang Dingxuan , Zhang Lei 
Published: September 2022

Abstract
Background

Osteoarthritis is closely related to the structure and stability of the ankle complex. The study was designed to determine the association between the distal tibiofibular syndesmosis (DTS) types and ankle structural abnormalities in the Chinese population.

Methods

A total of 147 participants were included. To assess the DTS types configurations and related parameters by magnetic resonance image (MRI). Joint space narrowing and osteophytes were measured using the ankle radiographic. Rank sun tests and binary Logistic regression were made to analyze the relationship between the syndesmosis configurations and the structural abnormality of the ankle.

Results

Five morphologic categories of the DTS, including chevron (19.6%), window’s peak (16.2%), flat (22.3%), trapezoid (32.0%), crescent (19.6%) were shown. The DTS types are not associated with Joint space narrowing osteophytes, tibiotalar surface angle (TT), or tibial lateral surface angle (TLS). however, there are statistical differences between different types of syndesmosis and tibial angle surface angle (TAS), and talar tilt angle (TTA).

Conclusions

The DTS classifications are associated with ankle structural changes in some ways. The statistical differences between types and TAS, and TTA needs to be explored in future studies.