bluuebunny/crossref_metadata_2025_split huggingface dataset:
Giant bladder stone resulting in acute kidney injury; a case report and review of literature
Authors: Issack Feysel Hassen , Gebresellasie Kaleab Habtemichael , Gebrehiwot Fitsum Gebreegziabher , Adem Mubarek Bargicho , Mummed Ferid Ousman , Hassen Ibsa Kedir 
Published: January 2022

Abstract
A giant bladder stone is very rare in adults. We report a case of giant bladder stone causing acute kidney injury in a 23-year-old male, who presented with lower urinary tract symptoms (LUTS) characterized by both irritative and obstructive LUTS. In addition, he also had episodes of reddish urine for the past decade. A non-contrast-enhanced CT scan was used for the diagnosis. Open cystolithotomy was performed and a 500g weighing stone was removed. He developed a superficial surgical site infection which was treated with wound care. He was discharged improved. Improvement in symptoms and serum creatinine was noted on follow-up.
Attenuating pandemic supply shocks with 3D printed emergency use equipment
Authors: Budhwani Karim I. , Pierce Albert T. , Arora Nitin 
Published: January 2022

Abstract
The fast-moving COVID-19 pandemic stressed supply chains even for some of the best prepared medical facilities. As a result, producing on-demand personal protective equipment (PPE) using additive manufacturing (AM) capabilities (3D-printing) emerged as a common strategy. While layer-by-layer processing confers several advantages to AM, it also imposes prohibitive print times, particularly for large volume parts. This leads to potential for using AM to rapidly produce smaller adaptors that modify available components for addressing critical shortages in emergencies. We applied this principle in developing a quick, simple, and low-cost adaptation of elastomeric half-mask respirators for emergency use in high-risk clinical settings. As we move toward reopening society, we must proactively build stronger bridges between engineering and medicine to respond to critical shortages in PPE ensuing from a potential second wave.
Data-Driven Modeling of Ultimate Load Capacity of Closed- and Open-Ended Piles using Machine Learning
Authors: Ulker Mehmet Barış Can , Altınok Emirhan , Taşkın Gülşen 
Published: January 2022

Abstract
Field pile load tests are fairly expensive experiments that can be applied to certain pile types required to be installed in full scale. Hence, it is neither practical nor efficient to perform a load test for every installed pile. While there exist many empirical relations for predicting pile capacities, such methods typically suffer from accuracy and generality. Therefore, current geotechnical practice still looks for methods to accommodate full-scale pile load testing to serve as both accurate and practical tools. In this study, load bearing capacities of closed and open-ended piles in cohesive and cohesionless soils are predicted using machine learning. Nine such methods are utilized in the analyses where CPT and pile data are considered as the learning features necessary to teach those methods the database gathered via a comprehensive search. Then, machine learning models are developed, and the databases are separated into five-folds according to the cross-validation-principle, which are used for both training and testing of the machine learning methods. Model predictions are validated with classical empirical equations. Results indicate that the Relevance Vector Regression and the Random Forest methods typically generate considerably better predictions than the other methods and empirical equations. Hence, machine learning methods are found as reliable tools to predict the pile load capacities of both open-ended and closed-ended piles provided that there is a large enough database and an appropriate method to use.
Hyaluronic acid Hydrogels Hybridized with Au-Triptolide Nanoparticle for Intra-articular targeted multi-therapy of Rheumatoid Arthritis
Authors: Li Chenxi , Liu Rui , Song Yurong , Zhu Dongjie , Yu Liuchunyang , Huang Qingcai , Zhang Zhengjia , Xue Zeyu , Hua Zhenglai , Lu Cheng , Liu Yuanyan 
Published: January 2022

Abstract
Triptolide (TP) is a DMARD highly effective in patients with RA. Hyaluronic acid (HA) hydrogels loaded RGD-attached gold nanoparticles containing TP were synthesized to alleviate the toxicity and increase therapeutic specificity. The hydrogels can be applied for targeted photothermal-chemo therapy, and in vivo imaging of RA. Heat was locally generated at the inflammation site after degradation of HA chains due to near-infrared resonance (NIR) irradiation of gold nanoparticles (AuNPs), and TP was released. Administration of the hybrid hydrogels containing low dosage of TP combined with NIR irradiation alleviated arthritic conditions and improved the inflamed joint in collagen-induced arthritis (CIA) mice. In vitro effect of the hydrogel was mediated through decrease of phosphorylation of mTOR and its substrate, p70S6K1, thus inhibiting mTOR pathway.
Improving Diversity and Quality of Adversarial Examples in Adversarial Transformation Network
Authors: Nguyen Duc-Anh , Minh Kha Do , Le Khoi Nguyen , Le Minh Nguyen , Hung Pham Ngoc 
Published: January 2022

Abstract
This paper proposes a method to mitigate two major issues of Adversarial Transformation Networks (ATN) including the low diversity and the low quality of adversarial examples. In order to deal with the first issue, this research proposes a stacked convolutional autoencoder based on pattern to generalize ATN. This proposed autoencoder could support different patterns such as all-feature pattern , border feature pattern , and class model map pattern . In order to deal with the second issue, this paper presents an algorithm to improve the quality of adversarial examples in terms of L 0 -norm and L 2 -norm. This algorithm employs an adversarial feature ranking heuristics such as JSMA and COI to prioritize adversarial features. To demonstrate the advantages of the proposed method, comprehensive experiments have been conducted on the MNIST dataset and the CIFAR-10 dataset. For the first issue, the proposed autoencoder can generate diverse adversarial examples with the average success rate above 99%. For the second issue, the proposed algorithm could not only improve the quality of adversarial examples significantly but also maintain the average success rate. In terms of L 0 -norm, the proposed algorithm could decrease from hundreds of adversarial features to one adversarial feature. In terms of L 2 -norm, the proposed algorithm could reduce the average distance considerably. These results show that the proposed method is capable of generating high-quality and diverse adversarial examples in practice.
Differential Transcriptomic Profiles in Canine Intestinal Organoids Following Lipopolysaccharide Stimulation
Authors: Sahoo Dipak K. , Borcherding Dana C. , Chandra Lawrance , Jergens Albert E. , Atherly Todd , Bourgois-Mochel Agnes , Severin Andrew J. , Ellinwood Matthew , Snella Elizabeth , Martin Martin , Allenspach Karin , Mochel Jonathan P. 
Published: January 2022

Abstract
Lipopolysaccharide (LPS) is associated with chronic intestinal inflammation and promotes intestinal cancer progression in the gut. While the interplay between LPS and intestinal immune cells has been well characterized, little is known about LPS and intestinal epithelium interactions. In this study, we explored the differential effect of LPS on proliferation and the transcriptome in 3D enteroids/colonoids obtained from dogs with naturally occurring gastrointestinal (GI) diseases, such as Inflammatory Bowel Disease (IBD) and GI mast cell tumor. The study objective was to analyze LPS-induced modulation of signaling pathways involving the intestinal epithelia and critical to colorectal cancer development in the context of IBD or a tumor microenvironment. While LPS incubation resulted in a pro-cancer gene expression pattern and stimulated proliferation of IBD enteroids and colonoids, down-regulation of several cancer-associated genes like CRYZL1, Gpatch4, SLC7A1, ATP13A2, and ZNF358 was also observed in tumor enteroids. Genes participating in porphyrin metabolism (CP), thiamine and purine metabolism (TAP2, EEF1A1), arachidonic acid, and glutathione metabolism (GPX1) exhibited a similar pattern of altered expression between IBD enteroids and IBD colonoids following LPS stimulation. In contrast, genes involved in anion transport, transcription and translation, apoptotic processes, and regulation of adaptive immune responses showed opposite expression patterns between IBD enteroids and colonoids following LPS treatment. In brief, the cross-talk between LPS/TLR4 signal transduction pathway and several metabolic pathways, such as fatty acid degradation and biosynthesis, and purine, thiamine, arachidonic acid, and glutathione metabolism, may be important in driving chronic intestinal inflammation and intestinal carcinogenesis.
The Court and the Monastery Complexes as Centers of Craft Production in Medieval Serbia
Authors: Fostikov Aleksandra 
Published: January 2022

Being important economical centers on the territory of medieval Serbia and places that in the division of power into sacral and secular stood out, the court and the monastery were the central places of the manor but also first grade centers i.e. urban settlements within boundaries or fence-encircled areas. This was especially the case with the court of the ruler or the head of the church. Thus, in parallel with the craftsmen who were working for the sovereign, landlord or for the monastery on the territory of the manor – the craftsmanship activity was also taking place within the court or monastery complex - on the territory of physically or imaginarily enclosed economic space - the immediate courtyard.
Unlike monasteries whose yard had been encircled and so there is no doubt to whom the workshop actually belonged, in the case of the fortified capital cities, it is difficult to make a distinction between the lord and city workshops. This is especially the case when there are no written sources or systematic archaeological excavations. Based on current knowledge it can be assumed that within the palace complex there were a blacksmith, a goldsmith, a mint, a potter and a tailor, and very likely shoemaker workshops. They were appropriately employing blacksmiths, weavers, gunsmiths, goldsmiths, jewelers, potters, craftsmen who worked on the production and decoration of clothes and shoes, and probably persons practicing the fine crafts, such as engraving. In the case of monasteries, there were blacksmith, goldsmith and potter workshops, and based on the tools it can be assumed that leather production was also present. Workshops with artisans for the production of the essential elements of books, especially within the scriptoriums, should be added to this list as well.
Among them, the most skilled ones were certainly the craft masters. The monastery and church circle were common to found in the working role of craftsmen in a secular environment, as well as secular persons working in the monasteries. Apart from the craftsmen who lived continuously in the complexes, there were also those who traveled with their masters, or stayed within the complexes for a prolonged time due to their working obligations. In that case and where the work was related to a large construction project, some of them stayed within the complexes for years.
Increasing Risk Factors for Non-Alcoholic Fatty Liver Disease; an Insight
into Chronic Periodontitis and Insulin Resistance
Authors: Thalla Sreenu , R. Kamaraj , A. Kavitha 
Published: January 2022

Abstract:
Non-alcoholic fatty liver disease (NAFLD) is marked by the excessive intrusion of triglycerides into hepatocytes without any role of alcohol consumption. Various risk factors have been attributed to this disease pathogenesis, including metabolic disorders, immune response, and even an intricate relationship between the two. The role of insulin resistance (IR) in NAFLD has long been known; however, the molecular basis of disease progression under this metabolic backdrop is still being investigated. Similarly, the periodontitis-mediated immune response is another major factor involved in NAFLD manifestation, which has generated huge interest. The prevalence of pathogenic bacteria elicits a strong immune response, which according to the studies shows a strong correlation with NAFLD state. Such pre-existing conditions have a strong probability of explaining the disease onset. Additionally, increasing reports on inflammatory response and its links to insulin resistance have further increased the scope of understanding NAFLD. Through this review, we aim to elaborate on these factors explaining their role in the disease progression.
Prevalence of High-Risk Antibiotic Resistant Acinetobacter baumannii in the Holy Cities of Makkah and Al-Madinah
Authors: Al-Sultan Abdulrahman A. 
Published: January 2022

Background:
Acinetobacter baumannii strains resistant to carbapenems are a global public health problem.

Objectives:
The aim of the present study is to evaluate the prevalence of genetic fingerprints associated with Metallo β-lactamases in A. baumannii in addition to the clonal diversity of A. baumannii in Makkah and Al-Madinah regions of Saudi Arabia, which receive a high number of international visitors.

Methods:
Multi-antibiotic resistant A. baumannii isolates were investigated. Bacterial isolation was conducted employing a basic bacteriological technique after confirming the ID of isolates. The antimicrobial susceptibility test was carried out using the Vitek 2 compact system. The molecular clonal diversity of the isolates was determined by Pulse Field Gel Electrophoresis (PFGE). Clusters were analyzed with BioNumerics software version 6.5. Dice coefficient was used for calculating the similarities.

Results:
The results indicated resistance in 82.5% of A. baumannii isolates against the carbapenems. All the isolates were found to be sensitive to colistin, while 5% of isolates were resistant to tigecycline. The screening of carbapenem-resistant A. baumannii isolates showed that the dissemination of imipenem and meropenem resistance was 81 and 84%, respectively, while the majority of the strains were susceptible to tigecycline and colistin. The blaOXA and blaVIM were the most encountered genes in A. baumannii isolates, while ISAba1 was the prominent insertion sequence. The genetic fingerprinting results (PFGE) revealed two types of epidemic clones: monoclonal and polyclonal models of 17 clusters.

Conclusion:
The current investigation indicates the diversity in genetic fingerprints of carbapenem-resistant A. baumannii in Makkah and Al-Madinah region of Saudi Arabia, and that two types of epidemic clones are present. It has also been demonstrated that such clones create serious infection dissemination to other parts of the world as heavy pilgrimage traffic is received throughout the year in Makkah and Al-Madinah, especially in the Haj season.
Reversing the Antibiotic Resistance “Yelp Effect” Through the Use of Emotionally Framed Responses to Negative Reviews of Providers: Questionnaire Study
Authors: Turner Monique Mitchell , Choung Hyesun , Bui Quoc-Ha Hannah Mai , Beck Paige , Ashraf Hera 
Published: January 2022

Background
The overuse of antibiotics has rapidly made antimicrobial resistance a global public health challenge. There is an emerging trend where providers who perceive that their patients expect antibiotics are more likely to prescribe antibiotics unprompted or upon request. Particularly, health care providers have expressed concern that dissatisfied patients will provide disparaging online reviews, therefore threatening the reputation of the practice. To better deal with the negative reviews and inform patients, some health care staff directly respond to patients’ online feedback. Engaging with patients’ online reviews gives providers an opportunity to prevent reputational damage and improve patients’ understanding of the antibiotic resistance problem.

Objective
We aim to test the effectiveness of different response strategies to the negative patient online reviews on the readers’ perceptions of the health care provider and their perceptions related to antibiotics resistance.

Methods
Two experiments were conducted to examine the impact of message tactics (apologizing, inducing fear or guilt) that can be employed by health care providers when responding to patients’ negative online feedback related to not receiving an antibiotic.

Results
Overall, our results demonstrated positive impacts of responding to patients’ online reviews. In study 1, we found apologetic messaging and use of emotional appeals in the response were effective in making readers feel more favorable toward the message. Readers also expressed a greater credibility perception toward the provider and willingness to visit the clinic when emotional appeals were used. Findings from study 2 largely supported the effectiveness of a fear-based response in improving the readers’ credibility perceptions and willingness to visit the clinic. The fear-inducing information was particularly effective among parent readers.

Conclusions
This paper demonstrated that a strategic response to online patient complaints could prevent reputational damage and minimize the potential negative impacts of the review. The results also glean insight into the step toward developing a novel intervention—crafting a persuasive response to patients’ negative feedback that can help improve the understanding of antibiotic resistance problems.
Hubungan psychological capital dengan komitmen organisasi pada aparatur sipil negara
Authors: Anggraini Gustina 
Published: January 2022

Organizational commitment is the willingness of members to have a relationship with the organization. High organizational commitment will lead to high on aspects like performance, discipline and achievement. A positive psychological state must be possessed because it can affect organizational commitment. Psychological capital is a developmental condition of a person’s positive psychological state and the emergence of self-efficacy, hope, resilience, and optimism so that it is related to organizational commitment. The purpose of the study was to determine the relationship between psychological capital and organizational commitment in ASN samples. Quantitative research in design and the data gathered from 125 ASN participants with at least one year of working experience in an organization or agency. Data were collected using psychological capital (PCQ) and organizational commitment scale (OCQ). Hypothesis testing was carried out with Pearson’s product moment correlation using SPSS. The results showed that there was a positive relationship between psychological capital and organizational commitment in state civil apparatus (r=0.87, p=0.000). It means the higher the psychological capital, the higher the organizational commitment.

Keywords: Organizational commitment, psychological capital, state civil apparatus
Spatial Plan of Wisma Athletes as A Defense in The Era of The Covid-19 Pandemic
Authors: Rahma Diva Miftachul , Ihsan F Firauz 
Published: January 2022

In this era of the COVID-19 pandemic, there are many things that need to be watched out for and also need to be prepared. The role of the government as one of the leaders of a country needs to have a plan to overcome these problems. One of the efforts made by the government is to create a Covid-19 emergency hospital by converting the Kemayoran and Pademangan Wisma Athletes. The selection of this athlete's home is considered to be able to accommodate patients affected by COVID-19. But not only that, every room in this emergency hospital is a shield for every patient. Each room in the athlete's house has its own role and function, not least as a means of defense for every patient, to support this, the use of descriptive and narrative analysis is to explain how the architectural layout in the athlete's house and also use narrative analysis techniques to focus on an idea that can be developed into a related part. From the results of this analysis, it is also expected to get results to provide new knowledge, about how patients in the athlete's house become a means of defense for themselves.
PEMANFAATAN INFRASTRUKTUR DAN RUANG PASCA PEMBANGUNAN INFRASTRUKTUR DI DESA KERTA, PAYANGAN, GIANYAR
Authors: Desak Putu Korpiyoni  
Published: January 2022

Indonesia terdiri dari kawasan perkotaan dan kawasan perdesaan. Tidak hanya kawasan perkotaan yang ditemukan permasalahan, kawasan perdesaan juga ditemukan permasalahan. Beberapa permasalahan di kawasan perdesaan yang belum bisa di tuntaskan adalah kurangnya infrastruktur yang bisa mendukung aksesibilitas, dan produktifitas distribusi hasil pertanian, hal ini menjadi penghambat pertumbuhan ekonomi kawasan perdesaan. Beberapa hal yang dibutuhkan untuk mendukung aktivitas pertanian masyarakat di kawasan perdesaan adalah perencanaan infrastruktur yang sesuai dengan kebutuhan masyarakat kawasan perdesaan, selain itu potensi dari kawasan perdesaan tersebut mulai terlihat. Desa Kerta terletak di Kecamatan Payangan Kabupaten Gianyar. Dijadikannya Desa Kerta sebagai objek penelitian dikarenakan terbangunnya infrastruktur secara masif dan diikuti perkembangan ruang selama enam tahun terlihat jelas sehingga sampai saat ini terbangun wisata desa. Hal ini membutuhkan analisa di setiap tahap perencanaan pada proses pembangunannya, sehingga Desa Kerta selama kurun waktu enam tahun dapat melakukan perencanaan dan pembangunan sesuai kebutuhan masyarakat Desa Kerta. Tujuan dari penelitian ini adalah untuk mengetahui perkembangan ruang yang terjadi akibat proses perencanaan dan pembangunan infrastruktur di Desa Kerta. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan pendekatan beberapa studi kasus. Hasil penelitian ini berupa analisa perencanaan dan pembangunan infrastruktur di Desa Kerta dalam kurun waktu enam tahun pada tahun 2014 hingga tahun 2019 serta kondisi pemanfaatan ruang pasca pembangunan infrastruktur yang terjadi di Desa Kerta.
Keberadaan Lesbian di Kota Syariat: Faktor dan Interaksi Subjek
Authors: Kasmaya  
Published: January 2022

This study aims to describe the way lesbians interact with the environment where the majority of them are Muslims and the factors that influence a person to become a lesbian. The method used is a qualitative method with a case study approach. The informants of this study were four lesbians who lived in the city of Banda Aceh. The results of this study indicate that there are several things that underlie social interactions that shape lesbian behavior in an environment where the majority of Muslims are Muslims, that is family factors, fun, and trauma. The way lesbians adapt and run a partner relationship is the same as for heterosexual couples in general. However, for a more intimate relationship, this lesbian couple avoids their daily activities, then changes their appearance like men so that people don't suspect them.
Abstrak
Penelitian ini bertujuan untuk mendeskripsikan tentang cara lesbian berinteraksi dengan lingkungan sekitar yang mayoritasnya umat muslim serta faktor yang mempengaruhi seseorang menjadi seorang lesbian. Metode yang digunakan adalah metode kualitatif dengan pendekatan studi kasus. Informan penelitian ini berjumlah empat orang lesbian yang tinggal di Kota Banda Aceh. Hasil penelitian ini menunjukkan bahwa ada beberapa hal yang mendasari interaksi sosial membentuk perilaku lesbian dalam lingkungan sekitar yang mayoritasnya umat muslim yaitu faktor keluarga, keisengan dan trauma. Adapun cara lesbian beradaptasi dan menjalankan hubungan pasangan adalah sama dengan pasangan heteroseksual pada umumnya. Namun, untuk hubungan yang lebih intim pasangan lesbian ini menghindari daerah kegiatannya sehari-hari, kemudian mengubah penampilan seperti lelaki agar masyarakat tidak menaruh ke curigaan terhadap mereka.