bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deliver bad news – a cross-sectional study of the communication strategies used by physicians at the Maputo Central Hospital, Mozambique
Authors: Schmauch Natália Ubisse , Rêgo Francisca , Pinto Emilia , Castro Luísa , Sacarlal Jahit , Rêgo Guilhermina 
Published: October 2022

Abstract
Background: Physician communication with the patient and the family is an indispensable tool both on the disease diagnosis and prognosis, and also through all the follow-up, improving patients’ quality of life. This is even more important in case of terminal disease and the patient has palliative needs. Thus, the aim of this study was to identify which bad news communication strategies doctors use in services that provide palliative care.
Methods: A cross-sectional, quantitative, and analytical study was developed with the physicians that worked at the departments that provide palliative care at the Maputo Central Hospital, Mozambique. A total of 121 doctors participated in this study. An existing questionnaire with 17 questions, already translated to Portuguese, was used, based on the Setting-Perception-Invitation-Knowledge-Emotions-Strategy(SPIKES) protocol, and complemented with socio-demographic questions. A question about the participants’ opinion regarding the inclusion of how to communicate bad news in hospital training was also added.
Results: Of the 121 doctors, 62 (51.2%) were male and 110 (90.9%) were general practitioners. The participants had a median age of 36 years old and medians of 8 years of clinical practice and of 3 years of work in the current service. The majority of the participants considered that they have an acceptable or good level of bad news communication skills and believed that they do it in a clear and empathic way, paying attention to the patients' requests and doubts; however, most were not aware of the existing tools to assist them in this task and pointed that this topic should be addressed in the undergraduate medical course and in hospital training.
Conclusions: This study adds new information about the bad news communication strategies used by doctors in the context of palliative care at the Maputo Central Hospital. Since palliative care are still being implemented in Mozambique, it is important to use protocols suitable to the reality of the country to allow the improvement in the conduct and attitudes of doctors towards patients and family members.
High proportion of Circulating CD8+CD28- senescent T cell in an independent predictor of distant metastasis in Nasopharyngeal Cancer after radiotherapy
Authors: Xu XiaoTian , Wei FangZe , Xiao Lin , Wu Runye , Wei BaoJun , Huang ShengKai , Yi JunLin , Cui Wei 
Published: October 2022

Abstract
Background: Nasopharyngeal Cancer is a kind of epithelial carcinoma, and common in east and southeast Asia. Distant metastasis after radiotherapy remains the main cause of treatment failure and immune system function.
Methods: To explore the immune-related prognostic factors, in our study we explored the immune cells in peripheral blood from total 332 nasopharyngeal carcinoma patients, in these immune cells, we include the CD8+CD28− T cells which is a unique T cells immunosenescent subset increased in human peripheral blood with increasing age and declining immune function. We first divided our cohort into training and validation cohort, and utilized flow cytometry to investigate the immune cells in peripheral blood of patients with nasopharyngeal carcinoma. Based on the results and clinical information, we utilized Cox regression and LASSO regression model to screen the PFS and DMFS prognostic factors in training cohort and used validation cohort to verify the results.
Results: Based on the prognostic factors we built nomograms to predict PFS and DMFS after radiotherapy and validated. Post treated EBV and the proportion of CD8+CD28-T cells were selected to predict PFS. Post treated EBV, the proportion of CD8+CD28-T cells and N stage were selected to predict DMFS. We also explored the expression in the different stage and the correlation between the proportion of CD8+CD28-T cells and systemic inflammation, post-treated immunosuppression.
Conclusion: All nomograms model we build have good predictive value. Proportion of CD8+CD28-T cells is a candidate prognostic biomarker for nasopharyngeal carcinoma.
Flat-Band Ferromagnetism in Pb2Sb2O7 by Self-Doped Mechanism
Authors: HASE Izumi , Higashi Yoichi , Eisaki Hiroshi , Kawashima Kenji 
Published: October 2022

Abstract
Electron systems with strong geometrical frustration have flat bands, and their unusual band dispersion is expected to induce a wide variety of physical properties. However, for such properties to emerge, the Fermi level must be pinned within the flat band. In this study, we performed first-principles calculations on the pyrochlore oxide Pb2Sb2O7 and theoretically clarified that the self-doping mechanism induces pinning of the Fermi level in the flat band in this system. Therefore, a very high density of states is realized at the Fermi level, and the ferromagnetic state becomes the ground state by a flat-band mechanism, even though the system does not contain any magnetic elements. This compound has the potential to become a new platform to project the properties of flat-band systems in the real world.
A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled Clinical Trial to Verify the Efficacy and Safety of Ansofaxine (LY03005) for Major Depressive Disorder
Authors: Zhang Hongyan , Mi Weifeng , Di Xiaolan , wang Yiming , Li Huafang , Xu Xiufeng , Li Lehua , Wang Hua-Ning , Wang Guoqiang , Zhang Kerang , Tian Feng , Luo Jiong , yang chanjuan , Zhou Yunfei , Xie Shiping , Zhong Hua , Wu Bin , Yang Dong , Chen Zhenhua , Li Yi , Chen Jindong , Lv Shuyun , Yi Qizhong , Jiang Zhiwei , Tian Jingwei 
Published: October 2022

Abstract
Major depressive disorder (MDD) is the most prevalent form of depression and is becoming a great challenge for public health and medical practice. Although first-line antidepressants offer therapeutic benefit, about 35% of depressed patients are not adequately treated, creating a substantial unmet medical need. A multicenter, double-blind, randomized, placebo-controlled phase 3 clinical trial was conducted in patients with MDD in China to assess the efficacy and safety of ansofaxine (LY03005), a potential triple reuptake inhibitor of serotonin, norepinephrine and dopamine. Eligible 588 MDD patients were included and randomly assigned (1:1:1) to 8-week treatment with ansofaxine 80 mg/day(n=187), ansofaxine 160 mg/day(n=186), or placebo(n=185). The primary efficacy endpoint was the MADRS total score change from baseline to the end of the study. Safety indexes included adverse events, vital signs, physical examinations, laboratory tests, 12-lead electrocardiograms (ECG) and evaluation of suicide tendency and sexual function.Significant differences were found in mean changes in MADRS total scores at week 8 in the two ansofaxine groups (80 mg, -20.0; 160 mg, -19.9) vs. placebo (-14.6; p <0.0001). All doses of ansofaxine were generally well-tolerated. Treatment-emergent adverse events (TEAEs) were reported by 137 (74.46%) patients in ansofaxine 80 mg group, 144 (78.26%) patients in ansofaxine 160 mg and 125 (67.93%) patients in placebo group. The incidence of treatment-related adverse events (TRAEs) were 59.2% (109 patients), 65.22% (120 patients) in the 80, 160 mg ansofaxine groups and 45.11% (83 patients) in the placebo group. The initial results of this trial indicate that ansofaxine (80, 160 mg per day) was effective and safe in the treatment of adult MDD patients. ClinicalTrials.gov Idenifier:NCT04853407.
Sorting-free Hill-based stability analysis of periodic solutions through Koopman analysis
Authors: Bayer Fabia , Leine Remco I. 
Published: October 2022

Abstract
In this paper, we aim to study nonlinear time-periodic systems using the Koopman operator, which provides a way to approximate the dynamics of a nonlinear system by a linear time-invariant system of higher order. We propose for the considered system class a specific choice of Koopman basis functions combining the Taylor and Fourier bases. This basis allows to recover all equations necessary to perform the Harmonic Balance Method as well as the Hill analysis directly from the linear lifted dynamics. The key idea of this paper is using this lifted dynamics to formulate a new method to obtain stability information from the Hill matrix. The error-prone and computationally intense task known by sorting, which means identifying the best subset of approximate Floquet exponents from all available candidates, is circumvented in the proposed method. The Mathieu equation and an n-DOF generalization are used to exemplify these findings.
A single-center, open-label trial on convenience and complications of rechargeable implantable pulse generators for spinal cord stimulation: The Recharge Pain Trial
Authors: Hajiabadi Mohammad Mehdi , Vicheva Petya , Unterberg Andreas , Ahmadi Rezvan , Jakobs Martin 
Published: October 2022

Abstract
Introduction: Rechargeable implantable pulse generators (r-IPGs) have been available for spinal cord stimulation (SCS) claiming to offer a longer service life but demanding continuous monitoring and regular recharging by the patients. The aim of the study (DRKS00021281; Apr 7th, 2020)of was to assess the convenience, safety, and acceptance of r-IPGs and their effect on patient lives under long-term therapy.
Materials & Methods: Standardized questionnaires were sent to all chronic pain patients with a r-IPG at the time of trial. Primary endpoint was the overall convenience of the charging process on an ordinal scale from "very hard" (1 point) to "very easy" (5 points). Secondary endpoints were charge burden (minutes/week), rates of user confidence and complications (failed recharges, interruptions of therapy). Endpoints were analyzed for several subgroups.
Results: n=40 data sets (42% return rate) were eligible for analysis. Patient age was 57.2 ± 12.6 (mean ± standard deviation) years with the r-IPG being implanted for 52.1 ± 32.6 months. The overall convenience of recharging was evaluated as "easy" (4 points). The charge burden was 112.7 ± 139 min/week. 92% of the patients felt confident recharging the neurostimulator. 37.5% of patients reported failed recharges. 28.9% of patients experienced unintended interruptions of stimulation. Subgroup analysis only showed a significant impact on overall convenience for different models of stimulators (p<0.05).
Conclusion: Overall, SCS patients feel confident handling a r-IPG at high rates of convenience and acceptable effort despite high rates of usage-related complications. Further technical improvements for r-IPGs are needed.
Detecting Cybercrime: An Evaluation of Machine Learning and Deep Learning Using Natural Language Processing Techniques on the Social Network
Authors: Amer Abdullah , Siddiqui Tamanna , Athamena Belkacem 
Published: October 2022

AbstractThe widespread use of online social networks has culminated in across-the-board social communication among users, resulting in a considerable amount of user-generated contact data. Cybercrime has become a significant issue in recent years with the rise of online communication and social network. Cybercrime has lately been identified as a severe national psychological concern among platform users, and building a reliable detection model is crucial. Cyberbullying is the phrase used to describe such online harassment, insults, and attacks. It has become challenging to identify such unauthorized content due to the massive number of user-generated content. Because deep neural networks have various advantages over conventional machine learning approaches, researchers are turning to them more frequently to identify cyberbullying. Deep learning and machine learning have several uses in text classification. This article suggested the novel neural network model through parameters of an algorithmic and optimization comparative analysis of nine category approaches, four neural networks, and five machine learning, in two scenarios with real-world datasets of cyberbullying. Moreover, this work also analyzes the impact of word embedding and feature extraction techniques based on text mining and NLP on algorithms' performances. We performed extensive experiments on the two scenarios with a split dataset to demonstrate the merit of this research, comparing nine classification approaches through five feature extraction techniques. Our proposed cybercriminal detection model using neural networks, deep learning, and machine learning outperforms the existing state-of-the-art method of cybercriminal detection in terms of accuracy achieving higher performance.
The integrability, equivalence and solutions of two kinds of integrable deformed fourth-order matrix NLS equations
Authors: Yao Yuqin , Zhou Hui , Li Fei 
Published: October 2022

Abstract
Based on the higher-order restricted flows, the first type of integrable deformed fourth-order matrix NLS equations, that is the fourth-order matrix NLS equations with self-consistent sources (FMNLSSCS) is derived. By virtue of the dbar-dressing method, the second type of integrable deformed fourth-order matrix NLS equations called the fourth-order matrix NLS-Maxwell-Bloch system (FMNLS-MB) is presented. We prove the equivalence of the FMNLSSCS and the FMNLS-MB successfully. Furthermore, N-soliton solutions are explicitly obtained by means of the Cauchy matrix method starting from corresponding Sylvester equation.
Timing of surgery for proximal humeral fracture treated with shoulder hemiarthroplasty, best results with surgery within 2 weeks
Authors: Demir Yilmaz , Vuorinen Alma , Gordon Max , Nordqvist Anders , Salomonsson Björn 
Published: October 2022

Abstract
Background
Preoperative delay may affect the outcome of proximal humerus fractures treated with shoulder hemiarthroplasty. There is currently no consensus for the recommended preoperative time interval.
The aim was to examine how the time to surgery with shoulder hemiarthroplasty after a proximal humerus fracture affected patient-reported outcome.
Methods
380 patients with proximal humerus fractures treated with shoulder hemiarthroplasty recorded from the Swedish Shoulder Arthroplasty Registry were included. Three self-reporting outcome instruments were used at follow-up after 1-5 years: a shoulder specific score, the Western Ontario Osteoarthritis of the Shoulder index (WOOS), the EuroQol health status component (EQ-5D-index) and subjective patient satisfaction assessment.
Results
Preoperative delay had a negative impact on the WOOS, EQ-5D and patient satisfaction scores (p < 0.01). The best result, measured with WOOS at minimum 1-year follow-up, was found when surgery was performed 6-10 days after the reported date of fracture. A delay of more than 10 days was shown be correlated with poorer outcomes.
Conclusions
The current recommendation in Sweden to perform shoulder hemiarthroplasty within two weeks after sustaining a proximal humerus fracture is considered valid.
Structural covariance network of the hippocampus-amygdala complex in medication-naïve patients with first-episode major depressive disorder
Authors: Zhang Lianqing , Hu Xinyue , Tang Mengyue , Hui Qiu , Zhu Ziyu , Hu Yongbo , Gao Yingxue , Li Hailong , Kuang Weihong , Gong Qiyong , Huang Xiaoqi 
Published: October 2022

Abstract
Background
The hippocampus and amygdala are densely interconnected structures that work together in multiple affective and cognitive processes that are important to the etiology of major depressive disorder (MDD). Each of these structures consists of several heterogeneous subfields. We aim to explore the topologic properties of the volume-based intrinsic network within the hippocampus-amygdala complex in medication-naïve patients with first-episode MDD.
Methods
High-resolution T1-weighted magnetic resonance imaging scans were acquired from 123 first-episode, medication-naïve and non-comorbid MDD patients and 81 age-, sex- and education level -matched healthy controls (HCs). The structural covariance network (SCN) was constructed for each group using the volumes of the hippocampal subfields and amygdala subregions; the weights of the edges were defined by the partial correlation coefficients between each pair of subfields/subregions, controlled for age, sex, education level and intracranial volume. The global and nodal graph metrics were calculated and compared between groups.
Results
Compared with HCs, the SCN within the hippocampus-amygdala complex in patients with MDD showed a shortened mean characteristic path length, reduced modularity, and reduced small-worldness index. At the nodal level, the left hippocampal tail showed increased measures of centrality, segregation and integration, while nodes in the left amygdala showed decreased measures of centrality, segregation and integration in patients with MDD compared with HCs.
Conclusion
Our results provide the first evidence of atypical SCN within the hippocampus-amygdala complex in patients with MDD, suggesting a potentially disrupted feedback or/and feedforward systems between the hippocampus and amygdala that underlying dysregulated emotional memory process in MDD.
Prevalence and Predictors of Birth Asphyxia Among Neonates in Bangladesh: A Cross-Sectional Study
Authors: Parvin Sonia , BakiBillah Abul Hasan , Hasan Istiaque , Chowdhury ABM Alauddin 
Published: October 2022

Abstract
Birth asphyxia is a severe clinical problem worldwide that contributes to neonatal mortality and morbidity. This study aimed to explore the prevalence of birth asphyxia and its associated risk factors among neonates attending in a selected Bangladeshi tertiary level public hospital. This descriptive cross-sectional study was conducted in Shaheed Suhrawardy Medical College & Hospital, Dhaka, from January to December 2019. A systematic sampling technique was selected for the study sample. Data were collected by conducting a face-to-face interview with the selected respondents. The validated APGAR score measured neonates’ health status. Among the 377 neonates, 11.93% had birth asphyxia.This study found a significant association (p = 0.039) between neonate’s health/asphyxia status and the young age (15 to 20 years) of mothers. In addition, term period (p = 0.03), low birth weight (p = 0.007), Caesarean section ((C-section) (p = 0.017)), abortion and prolonged labor duration (> 12 hours) were strongly associated with birth asphyxia in neonates. The study concludes that the young age of mothers, term period, low birth weight, C-section delivery, abortion, and longer labor duration were significantly associated with the birth asphyxia. It is recommended to raise extensive awareness among the husbands and other family members. Notably, parental training bears a pivotal role to play in maintaining and restoring maternal as well as neonatal health.
Difference in the emergency care provided to women who have suffered sexual violence, according to skin color: a cross-sectional retrospective study
Authors: Costa Evaldo Lima da , de Pádua Karla Simônia , Faúndes Anibal , Nunes Rui 
Published: October 2022

Abstract
Background: In Brazil, emergency healthcare for victims of sexual aggression should follow guidelines defining treatment, with notification by health centers being mandatory. Conversely, there is solid evidence that skin color or racial discrimination has led to significant social inequalities in health throughout the country. The objective of this study was to evaluate the quality of care provided to female victims of sexual aggression seen in public hospitals in the Federal District of Brasília, Brazil according to the victim’s self-reported skin color.
Methods: This cross-sectional, retrospective study evaluated the care provided to female victims of sexual violence seen at a public hospital within the State Health Department network in the Federal District of Brasília. The data analyzed were retrieved from the Brazilian National Health Surveillance Agency database, which contains the compulsory notification records registered at all healthcare services in the country. The study included 2,256 females of 1-79 years of age who received care at one of these hospitals between January 1, 2012 and December 31, 2016 following sexual aggression. The four types of treatment recommended for women who suffer sexual violence were taken into consideration: prophylactic treatment against human immunodeficiency virus, sexually transmitted and hepatitis B infections, and emergency contraception. The independent variable was the victim’s ethnicity/skin color.
Results: Overall, 50.4% of the women in the sample self-reported as being of mixed race or brown skinned, 37.4% as white and 12.2% as black. The percentage of white women who received any of the four components of emergency care following sexual violence was always higher than the percentage of brown- or black-skinned women receiving the same component. The differences between white and brown-skinned or black women were always much greater than the differences between brown-skinned and black women.
Conclusions: The quality of emergency care provided following sexual aggression was poorer in the case of black or brown-skinned women compared to white women. The data from the present study may contribute towards improving the quality of the emergency care provided to all women and adolescents who suffer sexual violence irrespective of their skin color, thus eliminating the discrimination identified here.
Domains of scale in cumulative effects of energy sector development on boreal birds
Authors: Crosby Andrew D. , Leston Lionel , Bayne Erin M. , Sólymos Péter , Mahon C. Lisa , Toms Judith D. , Docherty Teegan D.S. , Song Samantha 
Published: October 2022

Abstract
Context: Industrial development in Canada’s boreal forest creates cumulative environmental effects on biodiversity. Some effects may be scale-dependent, creating uncertainty in understanding and hindering effective management.
Objectives: We estimated cumulative effects of energy sector development on distributions of sixteen migratory songbird species at multiple spatial scales within the boreal region of Alberta, Canada, and evaluated evidence for scale domains in species responses.
Methods: We used a hierarchical, multi-scale sampling and modelling framework to compare effects of human footprint on sixteen boreal songbird species at five spatial scales. We used Bayesian Lasso to facilitate direct comparison of parameter estimates across scales, and tested for differences in grouped parameter estimates among species.
Results: We found consistent scale-dependent patterns, showing variable responses to development occurring at the smallest scale, little effect at intermediate scales, and stronger, mainly positive effects at the largest scales. Differences in grouped parameter estimates across scales showed strong evidence for scale domains in the response of songbirds to energy sector development.
Conclusions: Our evidence for domains of scale reflected differences between local scale habitat selection and landscape scale distributional effects. Our analysis provides a sampling and modelling framework for understanding effects of land-use change on biodiversity across multiple spatial scales. We show that limiting cumulative area of disturbance within a given management unit is the most likely path towards conserving avian biodiversity in this region.