bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative Analysis of lncRNA-miRNA-mRNA Regulatory Network Reveals the Key lncRNAs Implicated Potentially in the Differentiation of Adipocyte in Goats
Authors: He Changsheng , Wang Yong , Zhu Jiangjiang , Li Yanyan , Chen Juan , Lin Yaqiu 
Published: May 2022

Goats are popular in China because of their superior meat quality, delicate flesh, and unique flavor. Long noncoding RNAs (lncRNAs) play important roles in transcriptional and post-transcriptional regulation of gene expression. However, the effects of lncRNAs on adipocyte differentiation in goat has not been fully elucidated yet. In this investigation, we performed RNA-Seq analysis of intramuscular and subcutaneous adipocytes from Jianzhou Daer goat before and after differentiation, including both intramuscular preadipocytes (IMPA) vs. intramuscular adipocytes (IMA) and subcutaneous preadipocytes (SPA) vs. subcutaneous adipocytes (SA). A total of 289.49 G clean reads and 12,519 lncRNAs were obtained from 20 samples. In total, 3,733 differentially expressed RNAs (182 lncRNAs and 3,551 mRNAs) were identified by pairwise comparison. There were 135 differentially expressed lncRNAs (DELs) specific to intramuscular adipocytes, 39 DELs specific to subcutaneous adipocytes, and 8 DELs common to both adipocytes in these 182 DELs. Some well-known and novel pathways associated with preadipocyte differentiation were identified: fat acid metabolism, TGF-beta signaling pathway and PI3K-Akt signaling pathway. By integrating miRNA-seq data from another study, we also identified hub miRNAs in both types of fat cells. Our analysis revealed the unique and common lncRNA-miRNA-mRNA networks of two kinds of adipocytes. Several lncRNAs that regulate potentially goat preadipocyte differentiation were identified, such as XR_001918 647.1, XR_001917728.1, XR_001297263.2 and LNC_004191. Furthermore, our findings from the present study may contribute to a better understanding of the molecular mechanisms underlying in goat meat quality and provide a theoretical basis for further goat molecular breeding.
Mediating Role of Intimate Partner Violence Between Emotional Dependence and Addictive Behaviours in Adolescents
Authors: Macía Patricia , Estevez Ana , Iruarrizaga Iciar , Olave Leticia , Chávez Mᵃ Dolores , Momeñe Janire 
Published: May 2022

ObjectiveIntimate partner violence (IPV) has been related to emotional dependence and addictive disorders. This study aims to provide a global approach to analyse the relationship between these variables and to determine the factors underlying permanence in violent relationships.MethodsIt is a non-experimental, cross-sectional correlational design study. Participants had to have at least one dating relationship for at least 1 month to complete the questionnaire, which included the following instruments: emotional dependence scale (DEN), scale of violence in dating relationships (VREP) and impulse control disorders scale (MULTICAGE CAD 4).ResultsThe sample consisted of 1.533 adolescents, 53.9% were male (n = 826) and 46.1% female (n = 707), between 14 and 18 years. Emotional dependence correlated significantly with received violence (r = 0.37, p &lt; 0.001). Compulsive spending is strongly associated with emotional dependence (r = 0.21, p &lt; 0.001), whereas sex addiction is associated with received violence to a greater extent (r = 0.18, p &lt; 0.001). Received violence mediates on emotional dependence and addictions.ConclusionIPV is a risk factor for the perpetuation of addictive behaviours. It is advisable to promote affective education for developing resilience and adequate coping.
Partial Fibular Head Osteotomy is an Alternative Option in Treatment of Posterolateral Tibial Plateau Fractures: A Retrospective Analysis
Authors: Lu Yao , Wang Gen , Ren Cheng , Xu Yibo , Huang Qiang , Fan Shan , Li Ming , Zhang Kun , Li Zhong , Wang Qian , Ma Teng 
Published: May 2022

ObjectiveThis study aimed to evaluate the short-term effects of partial fibular head osteotomy for treating posterolateral tibial plateau fractures.MethodsA retrospective analysis was performed on 25 patients with posterolateral tibial plateau fractures who were treated using a partial fibular head osteotomy approach. Computed tomography was performed for fracture typing and evaluation. The mode of injury, time from injury to surgery, time for fracture union, range of motion of the knee, and complications were recorded. Knee joint function was evaluated using the Hospital for Special Surgery Mayo Score (HSS).ResultsThe mean follow-up period was 21.5 (range, 12–36) months. Fracture united in all patients and the average clinical healing time for fractures was 11.2 ± 1.9 (range, 8–16) weeks. The mean time from injury to surgery was 3.1 ± 1.8 (range, 1–10) days. The mean range of flexion was 131.6° ± 12.5° (range, 110°–145°). The mean range of extension was 1.4°–4.2° (range, −5°–10°). The mean HSS at the final follow-up was 93.5 ± 5.4 (range, 79–100). None of the patients exhibited symptoms of common peroneal nerve injury, knee instability, or upper tibiofibular joint injury. One patient had a superficial infection and was treated with surgical dressing.ConclusionThe partial fibular head osteotomy approach is a feasible alternative for treating posterolateral tibial plateau fractures.
Kandungan Pigmen dan Aktivitas Antioksidan Rumput Laut Ulva dan Caulerpa
Authors: Samad Gadis Purnama , Sanger Grace , Kaseger Bertie Elias , Salindeho Netty , Montolalu Roike I , Makapedua Daisy Monica 
Published: May 2022

Rumput laut merupakan salah satu sumber daya hayati yang terdapat di wilayah pesisir, terutama di pantai yang mempunyai rataan terumbu karang. Rumput laut mempunyai tiga jenis pigmen utama, yaitu klorofil, karotenoid, dan fikosianin. Setiap jenis pigmen mempunyai berbagai manfaat khusus bagi kesehatan seperti antioksidan, antibakteri, antikolestrol, pembengkakan, antikanker, antiperadangan dan lain-lain. Penelitian ini bertujuan untuk mengetahui kandungan pigmen dan aktivitas antioksidan rumput laut ulva dan caulerpa. Rumput laut lalu di ekstraksi menggunakan metode maserasi dengan pelarut alkohol 96%. Analisis dalam penelitian ini terdirri dari : Klorofil a, klorofil b, total klorofil dan aktivitas antioksidan dengan menggunakan DPPH. Hasil analisis menunjukan bahwa rumput laut caulerpa memiliki kadar pigmen lebih tinggi yaitu total klorofil 12,96 mg/L sedangkan rumput laut ulva total klorofilnya yaitu 6,79 mg/L. Antivitas antioksidan tertinggi adalah rumput laut caulerpa dengan IC50 1,70 ppm sedangkan rumput laut ulva IC50 2.32 ppm
Da Vinci’s Vitruvian Man, Golden Ratio and Anthropometrics
Authors: Alzyoud Jihad A. M. , Jacoub Khaldun M. , Omoush Samya A. , Al-Shudiefat Abd Al-Rahman S. 
Published: May 2022

Objectives: Divine golden ratio (Phi = 1.618) observed in several human body parts such as, heart, dentition and upper limb tends to present homeostasis in anatomy and physiology. This cross sectional survey study investigates the relationship of golden ratio with BMI, GPA, gender and blood serotypes in Jordan.
Methods: Demographic features including GPA, body weight, lengths of some body parts and ABO/Rh blood groups were measured for 380 undergraduate students of matched age (19.14±0.76) and matched sex ratio. Navel-Foot/Height, Forearm-Hand/Armpit-hand and BMI were calculated. Golden ratio fitness was calculated based on phi and standard deviation of collected data.
Results showed significant gender differences in the means for all body lengths measured, GPA, BMI, and calculated ratios. Golden ratio fitted bodies students were 40.5% (Females > males). The overall prevalence of overweight and obesity was 15% (females < males), while 80% (females > males) have normal weight. Among the overweight and obese students 77.2% (44/57, females less than males) lies outside the golden ratio. The overall prevalence of GPA grades above good were 51.3% (females > males) and among them 47.7% (93/195, females > males) fit golden ratio while 67.2% of the good or below GPA grades (121/180, females < males) did not fit golden ratio. No significant difference between ABO-Rh system related to gender or golden ratio fitness. Statistically, a significant association was found between golden ratio and the three parameters BMI, GPA and gender.
Conclusions: Students who are golden ratio fitted bodies were more likely to have better BMI and GPA especially females.
FORMAS SIMPLES E PERIFRÁSTICAS DE PRETÉRITO MAIS-QUE-PERFEITO DO INDICATIVO E DE PRETÉRITO IMPERFEITO DO SUBJUNTIVO EM VARIAÇÃO
Authors: Coan Márluce , Sousa Francisco José Gomes de , Romualdo Laila Cavalcante 
Published: May 2022

Via análise de 837 dados de 1887 a 2012, provenientes de revistas históricas do Instituto do Ceará, mostramos como a forma de pretérito mais-que-perfeito simples foi perdendo espaço ao imperfeito do subjuntivo na codificação da função conjuntiva, especializando-se em contextos bastante restritos, especialmente aqueles nos quais há verbo de estado, dicendi ou modal, bem como ausência de conector. Ademais, seu principal nicho de ocorrência é a sincronia de 1887 a 1899. Em análise global, os dados estão assim distribuídos: 39 dados de pretérito mais-que-perfeito simples, 609 dados de pretérito imperfeito do subjuntivo, 85 de pretérito mais-que-perfeito composto do subjuntivo, 11 de perífrase verbal do mais-que-perfeito simples do indicativo e 93 de perífrase verbal do pretérito imperfeito do subjuntivo. Em termos teóricos, aludimos a dois dos princípios de mudança propostos por Weinreich, Labov e Herzog (1968): transição e restrições. Mostramos o cenário de transição, ao considerarmos tendências de uso de cada uma das formas sob análise por sincronia: 1887-1899; 1944-1956 e 2000-2012, bem como restrições de uso, ao mapearmos contextos de ocorrência por tipo verbal, uso de conector, polaridade, tipo oracional, gênero textual e sincronia. Trata-se de empreitada que possibilita mais conhecimento sobre a gramática do Português e sobre a história da língua, por mostrar como certas mudanças foram consolidadas, que fatores contribuíram e quais são, ainda, os contextos de resistência.
Palavras-chave: função conjuntiva, pretérito mais-que-perfeito, pretérito imperfeito do subjuntivo.
PRETÉRITO IMPERFEITO (INDICATIVO/SUBJUNTIVO): ANÁLISE VARIACIONISTA DA FUNÇÃO DE COTEMPORALIDADE A UM PONTO DE REFERÊNCIA PASSADO NO FALAR POPULAR DE FORTALEZA
Authors: Araújo Alexandra Maria de Castro e Santos , Rocha Francion Maciel 
Published: May 2022

O presente trabalho tem como objeto de estudo a variação entre o pretérito imperfeito do indicativo e o pretérito imperfeito do subjuntivo na função de cotemporalidade a um ponto de referência no passado, sob o aparato teórico-metodológico da Sociolinguística Variacionista (LABOV, 2008) e do Funcionalismo (GIVÓN, 2001; 1993). Foram analisados trinta e seis informantes do NORPOFOR (Norma Popular de Fortaleza), distribuídos em células ortogonais por sexo, faixa etária e escolaridade. Localizamos, nos inquéritos, 123 dados, sendo 74 de imperfeito do indicativo e 49 de imperfeito do subjuntivo, os quais foram testados mediante os seguintes grupos de fatores: tipo de oração subordinada; tipo de verbo da oração principal; presença/ausência de advérbio ou locução adverbial na oração principal; presença/ausência de locução verbal na subordinada; sexo; faixa etária e escolaridade. Os resultados obtidos indicam que a oração subordinada substantiva e os verbos cognitivos na oração principal motivam o uso do imperfeito do indicativo.
Palavras-Chave: Tempo. Variação. Cotemporalidade. Ponto de referência.
The FORMULATION AND EVALUATION O FORMULATION AND EVALUATION OF THE PREPARATION OF HAIR TONIC Ethanol Extract of Patchouli Leaves (Pogostemon cablin Benth.) TO OVERCOME HAIR LOSS
Authors: Barus Bunga Rimta , Meliala Linta 
Published: May 2022

Nilam leaves contain flavonoids. flavonoids that have activity that can accelerate hair growth and prevent hair loss. The purpose of the study was to make a hair tonic preparation containing patchouli leaf extract and to determine the concentration of the best formula to treat hair loss. Hair tonic is made with nilam leaf extract at concentrations of 5%, 10%, 15%. The ingredients for making Hair Tonic include propylene glycol, propyl paraben, methyl paraben, menthol, sodium metabisulfite, 96% ethanol, Ol. Rosae, Aquades. The method of the study an experimental method with extraction by maceration for 5 days and remaceration for 2 days using 96% ethanol as solvent. Evaluation of Hair Tonic preparations includes homogeneity, pH, organoleptic, viscosity, irritation, preference, and hair growth effectiveness test. The effectiveness test on hair growth in rabbits was carried out on 5 rabbits with 5 treatment groups, namely, positive control group Hair Tonic nature, negative control group, 5% concentration group, 10% concentration group, and 15% concentration group. The analysis of the data on growth testing using One Way Anova. Hair growth data on day 12 were positive control 0.95 mm, negative control 0.03 mm, formula 1 (5%) 0.08 mm, formula 2 (10%) 0.13 mm, formula 3 (15%) 0.83mm. The best formula to treat hair loss is hair tonic with a concentration of 15% nilam leaf ethanol extract. It can be concluded that the greater the concentration of nilam leaf extract given to each treatment, the faster the hair growth.
HUBUNGAN POLA MAKAN DENGAN KEJADIAN DIABETES MELLITUS DI PUSKESMAS NAMORAMBE KABUPATEN DELI SERDANG
Authors: Tarihoran Yessica , Silaban Dewi F 
Published: May 2022

Diabetes Mellitus (DM) is a degenerative’s disease which really has been associated with Diet. Diet is depiction abaout the various, amount and composition of foodstuff to some one who eaten everyday. The change of life style shifted from traditional Diet that contain more carbohydrate and fibre of vegetables to the modern Diet in the instaneous form in diet with hinger fat, protein, sugar, sald and e few fibre and result in many disease Inclucde DM. According to WHO, Indonesian is in 5th rank of number of patient with DM in prevalence 1,2% - 2,3% of the total population. The purpose of the research is to know about the relationship on Diet with Diabetes Mellitus type 2 in the Puskesmas Biru – Biru regency of Deli Serdang. This research is a descriptive analytic with cross sectional design (study cut latitude). The sampling method used to accidental sampling that consist of 44 Respondents. Research instruments used to quistionnaries study consisted of 20 questions. The answer of questions which there are in kuesioner, the data that collected is being analized using the chi - square test and counted by SPSS program. This result of this research which is gain the trusted level of 95 % show value p=0,001. This p value is smaller than α = 0,05. The conclusion of this research is showed that a significant relationship on diet with Diabetes Mellitus type-2 in the Puskesmas Namorambe, regency of Deli Serdang. The important suggestion of the medical staff and paramedic and nutritonist is to provide the patient with DM with information who visit Puskesmas Namorambe, to regualte the diet in good condition.
Behaviours and Characteristics of Digital Natives Throughout the Teaching-Learning Process: A Systematic Review of Scientific Literature from 2016 to 2021
Authors: Vitvitskaya Olga , Suyo-Vega Josefina Amanda , Meneses-La-Riva Monica Elisa , Fernández-Bedoya Víctor Hugo 
Published: May 2022

Information and communication technologies have generated transformations in the behaviour of digital native university students, which affect the teaching-learning process in the scenario of the Covid-19 pandemic. The objective of this study was to systematize the scientific evidence on university teaching strategies related to the behaviour of digital natives and the characteristics of their learning. The method employed was a systematic review of scientific articles from the EbscoHost, Scopus, Proquest, Eric and Scielo databases through the Boolean operators AND and OR. Initially, 51 638 records were obtained, of which only 26 met the inclusion criteria (years of publication, language, subject matter, free availability). The results show in the articles that most digital natives actively use social networks on a daily basis, while others conduct research or produce digital content with varying degrees of difficulty, some adapt quickly to new innovations related to technology, and many easily multitask and perform self-regulated learning, while demanding a more flexible teaching where learning is fast and practical. However, the attention of digital natives is dissipated by other interests such as social networks (generating cyber laziness), a situation that can lead to antisocial behaviour and self-exclusion from physical reality (phubbing). In conclusion, digital natives require greater attention from their university teachers, who must innovate in the teaching-learning process using the virtual environment, raising the interest of digital natives, to generate an autonomous learning where they can strengthen their skills and competencies for the achievement of their professional development.

Received: 11 December 2021 / Accepted: 23 March 2022 / Published: 5 May 2022
Position of Higher Education System Graduates in the Labor Market: Search For New Opportunities
Authors: Syzdykova Makhpal Barkhiyayevna , Bimakhanov Talant Duisenuly , Fursova Valentina Vladimirovna , Makhambetova Maria Alievna , Abikenov Zharkynbek Oralbekovich 
Published: May 2022

The ongoing socio-economic and socio-cultural changes bring about significant alterations in the social structure of society and the institution of education. This calls for in-depth research to predict the further development of social processes and determine effective methods of managing them at the society and regional levels. The employment of university graduates has essentially acquired the characteristics of a new social process after the abolition of obligatory employment by distribution. The emergence of new statuses (for example, mixed statuses), in which university graduates often find themselves being unemployed or working outside their professions, has become an acknowledged social fact. The interest of many sociologists in this problem is also due to changes in the functions of social institutions, including the institution of education, an important part of which is higher education. The study focuses on the importance of such obstacles as contradictions between the qualification programs, teaching methods, graduates’ competencies, employers’ requirements for the same competencies and qualifications, the mismatch between the studied theory and practice, and the identification and justification of the main employment strategies for university graduates. The study objectives are pursued through descriptive data analysis and the qualitative approach with a questionnaire as the main data collection method. The study is conducted on a sample of 130 organization leaders. The aforementioned problems and shortcomings of Kazakh university graduates’ training are detected and analyzed using comparative analysis. In accordance with the specifics of the labor market, the authors identify the market, paternalistic, and traditional strategies of university graduates’ employment.

Received: 21 December 2021 / Accepted: 16 March 2022 / Published: 5 May 2022
Information Technology Governance in the Tunisian Banking Industry: An Exploratory Study
Authors: Harguem Saida , Boubaker Karim Ben , Echatti Houcine 
Published: May 2022

Information Technology (IT) has become the foundation for supporting and sustaining businesses. IT strategic importance has prompted many organizations to extend Governance to IT and place it high on their agendas. Banks are among those organizations that heavily use IT to enhance their service delivery capabilities. Besides, globalization, competition, and compliance requirements pushed banks to consider IT Governance as part of their overall corporate governance strategy. Past studies have shown that IT Governance in the financial industry is more mature than in other sectors. However, there is little information about IT Governance in economically developing nations. This article conducted a Delphi study to evaluate the Perceived Efficiency and Ease of Implementation of IT Governance practices in the Tunisian banking industry. The results show that compared with Process and Relational Mechanisms, Structural Practices are perceived to be more effective and easier to implement. This research helps to understand better the current state of IT Governance Implementation in less developed countries.

Received: 30 November 2021 / Accepted: 19 March 2022 / Published: 5 May 2022
Tri Pramana Values in Educational Pedagogy
Authors: Paramartha Wayan , Sustiawati Ni Luh , Sukrawati Ni Made , Sugiharni Gusti Ayu Dessy 
Published: May 2022

This paper aimed to discuss systematically the study of Tri Pramana values in learning. This paper was divided into three parts, namely: 1) Tri Pramana's position in education; 2) Actualization of Tri Pramana Values in Learning, and 3) This paper was closed by presenting a conclusion which was the answer to the problems raised from this paper. The writing method used literature study and comparative analysis. The results of the analysis showed that the position of the Tri Pramana learning concept is similar to the new version of Bloom's taxonomy. So that Tri Pramana can be interpreted as an approach to learning that consists of three parts (Sabda Pramana, Pratyaksha Pramana, and Anumana Pramana). The learning indicators found in Sabda Pramana (Agama Pramana) were "references and affirmations"; in Pratyaksha Pramana were “observation, asking questions, gathering information, processing information, and communicating”; and in Anumana Pramana were "summarizing, responding, linking, formulating, colligate". The Tri Pramana concept can be used as an improved alternative to the scientific approach applied to the current learning curriculum in Indonesia.

Received: 2 February 2022 / Accepted: 8 April 2022 / Published: 5 May 2022
The Nexus between Top Management Support on Change Management, Cloud ERP Implementation, and Performance of SMEs
Authors: Jayeola Olakunle , Sidek Shafie , Sanyal Shouvik , Hasan Md. Meraj , Singh Amarendra Pratap , Hasan Syed Inamul 
Published: May 2022

Top management support (TMS) is a critical success factor in cloud computing (CC) implementation and firm performance. However, extant empirical research on these relationships has obtained mixed findings due to earlier studies focusing on a one-dimensional TMS construct with diverse measurement items that muddle up different behaviours of top management. TMS is typically a multi-dimensional construct, such as TMS change management (TMSCM), TMS resource provision (TMSR), and TMS vision sharing (TMSV). The aim of this study is to examine a specific TMS dimension, TMSCM, on cloud ERP implementation and, further, to measure the effect of TMSCM on the financial performance of manufacturing small and medium-sized enterprises (SMEs) through the mediating effect of cloud ERP implementation. The proposed research model was validated using partial least squares structural equation modelling (PLS-SEM) with a sample of 204 Malaysian manufacturing SMEs. Results reveal that TMSCM significantly impacts cloud ERP implementation and financial performance. Moreover, cloud ERP implementation is a significant driver of financial performance, and it partially mediates the relationship between TMSCM and financial performance. Contributing to disentangling the mixed findings of TMS impact on cloud ERP implementation and firm performance, this study also generates insights for practitioners that they need to balance TMSCM and cloud ERP implementation to improve the financial performance of SMEs.

Received: 17 December 2021 / Accepted: 21 February 2022 / Published: 5 May 2022