bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Assessment on Computation Offloading Mechanism in Mobile Edge Computing (MEC) --Manuscript Draft—
Authors: Sharma Aarti , Diwaker Chander 
Published: June 2022

Abstract
Mobile Edge Computing (MEC) is the application of cloud computing that is used to provide cloud services and advanced mobile applications to mobile users. The requirement of mobile users increases continually for accessing modern applications and cloud services at very high data speed and with less delay on their mobile devices. As the rate of demand increases for accessing applications and services by mobile users then it may increase the delay during transmission also data rate for accessing resources is decreasing. To handle these kinds of hazards, edge computing provides a computation offloading paradigm in which local edge servers are used to process user requests locally so that the data rate for accessing services and using modern mobile applications increases whereas the delay of accessing services from clouds also decrease as the services and applications are accessed locally by mobile users through local edge core network. In this paper, an attempt has been made to present offloading mechanism and its impact on MEC. The offloading can be categorized into three main categories such as decision-making regarding the offloading of computations, distributing computing resources within MECs, and management of mobility The paper presents an assessment of various offloading techniques with various parameters such as energy consumption, delay, execution time and system utility. The result depicts that in partial offloading the energy consumption, delay, and execution time are less and the system utility is more in perspective of other offloading techniques Furthermore, we present future direction and research challenges in MEC.
A Global Survey on the Utilization of Cryotherapy and Compression Therapy for the Prevention of Chemotherapy-Induced Peripheral Neuropathy
Authors: Chan Alexandre , Elsayed Amna , Ng Ding Quan , Ruddy Kathryn , Loprinzi Charles , Lustberg Maryam 
Published: June 2022

Abstract
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect that is highly prevalent among cancer patients undergoing chemotherapy. There is a growing use of cryotherapy (CryTx) and compression therapy (ComTx) to prevent CIPN at cancer centers worldwide. In this study, we examined the awareness and recommendation of these modalities and evaluated factors associated with awareness. In addition, we investigated the type of technology utilized, barriers to implementation, and perceived adverse events of CryTx and ComTx.Methods: Active members of the Multinational Association of Supportive Care of Cancer (MASCC) were invited to complete an electronic survey that was sent via SurveyMonkey between September to October 2021. The survey assessed participants’ awareness, recommendation, usage, barriers to utilization, and perceived adverse events of CryTx and ComTx. Descriptive statistics and multiple logistic regression were utilized to analyze findings.Results: Out of 184 participants, 70.1% were physicians, 73.4% had over 10 years of practice, and 49.5% were practicing in an outpatient setting. While more than half (63.3%) of participants indicated awareness of CryTx for taxane-induced peripheral neuropathy, less than a quarter (22.8%) indicated recommendation in their practice setting. Factors associated with higher awareness of CryTx for patients receiving taxanes include living in Europe (OR=2.69, 95% CI [1.28-5.64], p=0.009), not practicing in an inpatient setting (OR=3.15, 95% CI [1.45-6.85], p=0.004), and self-identifying as non-physician (OR=2.40, 95% CI [1.03-4.37], p=0.041). Commercial cooling (31.5%) and compression (16.8%) gloves and socks were the most used modalities for CryTx and ComTx, respectively. The most identified barriers to CryTx and ComTx utilization include insufficient evidence (53.5%), logistics (34.8%), and patient discomfort (23.4%). Redness/irritation of skin (27.7%) and numbness/tingling (24.5%) accounted for about half of the perceived adverse events associated with use of CryTx and ComTx. Conclusion: Results of our global survey illustrated that there are varying modes in the delivery of CryTx and ComTx among cancer centers around the world. Education of the utilization of CryTx and ComTx, in addition to efficacy and implementation studies, are needed to close the gap between awareness and implementation in clinical practice.
General practitioner care in nursing homes during the first wave of the COVID-19 pandemic in Germany: A retrospective survey among nursing home managers
Authors: Kühl Anja , Hering Christian , Herrmann Wolfram , Gangnus Annabell , Kohl Raphael , Steinhagen-Thiessen Elisabeth , Kuhlmey Adelheid , Gellert Paul 
Published: June 2022

Abstract
Background
Though evidence on the detrimental impact of the COVID-19 pandemic in nursing homes is vast, research focusing on general practitioners’ (GP) care during the pandemic in nursing homes is still scarce.
Methods
A retrospective online survey among 1,010 nursing home managers in Germany was conducted during the first wave of the COVID-19 pandemic between November 2020 and February 2021. Associations between perceived deficits in GP care (routine and acute visits) and both general and COVID-19-related characteristics of nursing homes were analysed using multiple logistic regression analyses.
Results
The majority of nursing home managers reported no deficits in GP care (routine visits, 84.3%; acute visits, 92.9%). Logistic regression analyses revealed that deficits in GP care (routine visits) were associated with visiting restrictions for GPs (p < .001) and nursing home size. Small nursing homes (1–50 residents) were more likely to report deficits in GP care (routine visits) compared to medium (51–100 residents; p = .05) and large nursing homes (> 100 residents; p < .05). Further, deficits in GP care (acute visits) were associated with dementia as a focus of care (p < .05) and the burden of insufficient testing for SARS-CoV-2 among residents (p < .05). Moreover, visiting restrictions for GPs were associated with dementia as the focus of care (p < .05) and the COVID-19 incidence at the state (Bundesstaat) level (p < .05). Finally, COVID-19 cases in nursing homes were associated with size of nursing homes (p < .01; p < .001), COVID-19-incidence on the state level (p < .05; p < .01) and the burden of insufficient testing capacities for SARS-CoV-2 among residents (p < .01).
Conclusion
We found structural factors associated with GP care deficits during the pandemic. New concepts for GP care should be implemented in pandemic preparedness plans to ensure high quality, consistent, and reliable GP care as well as effective infection prevention measures in nursing homes.
On the p-Renyi entropy power for nonlinear diffusion equations on Riemannian manifolds
Authors: Wang Yu-Zhao , Zhang Hui-Ting 
Published: June 2022

Abstract
In this paper, we use a new method to prove the concavity of $p$-R\'enyi entropy power for doubly nonlinear diffusion equations on compact Riemanian manifolds with nonnegative Ricci curvature based on an explicit variational formula via trace free tensors. Moreover, we obtain the NIW formula between $p$-Renyi entropy power, $p$-Fisher information and $W$-entropy for doubly nonlinear diffusion equations.
High mobility of isolated three-fold polar vertices by electric fields
Authors: Li Mingqiang , Yang Tiannan , Chen Pan , Wang Yongjun , Zhu Ruixue , Li Xiaomei , Shi Ruochen , Liu Heng-Jui , Huang Yen-Lin , Ma Xiumei , Zhang Jingmin , Bai Xuedong , Chen Long-Qing , Chu Ying-Hao , Gao Peng 
Published: June 2022

Abstract
Recently various topological polar structures have been discovered in oxide thin films. Despite the increasing evidence of their switchability under electrical or mechanical fields, the dynamic property of an isolated one, which is usually required for applications such as data storage, is still absent as they are always formed as arrays in thin films and evolve together due to strong interactions with their neighbors. Here, we show the controlled nucleation and high mobility of isolated three-fold vertices under an applied electric field. At PbTiO3/SrRuO3 interfaces, nanosized three-fold vertices are formed. A two-unit-cell thick SrTiO3 layer provides critical electrical boundary conditions for the formation of three-fold vertices. Utilizing the SrTiO3 layer and in situ TEM electrical testing system, we found isolated three-fold vertices can move a long distance along the interface under electric fields in a controllable and reversible manner. Microstructural evolution details of the nucleation and propagation of isolated three-fold vertices are further revealed by phase-field simulations. This work demonstrates the high mobility of isolated three-fold vertices, shedding light on the extraordinary dynamic properties of isolated topological polar structures.
On order isomorphisms intertwining semigroups for Dirichlet forms
Authors: Li Liping , Lin Hanlai 
Published: June 2022

Abstract
This paper is devoted to characterizing the so-called order isomorphisms intertwining the L2 -semigroups of two Dirichlet forms. We first show that every unitary order isomorphism intertwining semigroups is the composition of h-transformation and quasi-homeomorphism. In addition, under the absolute continuity condition on Dirichlet forms, every (not necessarily unitary) order isomorphism intertwining semigroups is the composition of h-transformation, quasi-homeomorphism, and multiplication by a certain step function.MSC Classification: 60J46 , 60J35 , 31C25
Morphological relationships between external auditory canal and vital structures of tympanic cavity
Authors: Ohira Shinya , Komori Manabu , Nakamura Mitsuto , Matsumura Kentaro , Osafune Hiroshi , Kajiwara Riko , Wada Kota 
Published: June 2022

Abstract
Purpose
We aimed to evaluate the morphology of the external auditory canal (EAC) using a three-dimensional (3D) reconstruction of computed tomography (CT) scans of the temporal bone to corroborate and predict important anatomical structures involved in middle ear surgery based on the EAC morphology.
Methods
Temporal bone CT from 62 patients (120 ears) was used to perform 3D reconstruction (maximum intensity projection), of which 32 patients (60 ears) had chronic otitis media and 30 patients (60 ears) had normal temporal bones. The anatomical morphology of the EAC, tympanic sinus, vertical portion of the facial nerve, and jugular bulb were measured, and the anatomical relationship between the EAC morphology and important structures of the middle ear was analyzed.
Results
In ears with chronic otitis media, the overhang of the inferior wall of the EAC was significantly more than that in normal ears, and the antero-posterior length of the bony tympanic ring was short. Furthermore, the tympanic sinus was shallow, and vertical portion of the facial nerve tended to run outward. The EAC morphology correlated with the tympanic sinus depth and outward orientation of the vertical portion of the facial nerve.
Conclusion
A severe overhang of the inferior wall of the EAC and short antero-posterior length of the bony tympanic ring indicates a higher possibility of a shallow tympanic sinus and an outward orientation of the vertical portion of the facial nerve. These findings aid in predicting the difficulty of tympanic sinus operation and reducing facial nerve damage risk during EAC excision.
Benchmark Assessment for Optimization Andacceleration Libraries in Deep Learning-Based Models
Authors: Liang Gongbo , Alsmadi Izzat , Xin Xin 
Published: June 2022

Abstract
Deep Learning (DL) models are widely used in machine learning due to their performance and abilityto deal with large datasets while producing high accuracy and performance metrics. The size ofsuch datasets and the complexity of DL models cause such models to be complex, consuming largeamount of resources and time to train. Many recent libraries and applications are introduced todeal with DL complexity and efficiency issues. Neural network-based models have utilized stateof the art optimization and acceleration libraries to scale up the size of training datasets and thenumber of parameters in the models themselves. In this paper, we evaluated one example, MicrosoftDeepSpeed library through classification tasks. DeepSpeed public sources reported classificationperformance metrics on the LeNet architecture. We extended this through evaluating the libraryon several modern neural network architectures, including convolutional neural networks (CNNs)and Vision Transformer (ViT). Results indicated that neural network models for imaging tasks areimproved through using the DeepSpeed library in general.
HuR-induced CDK2 translational enhancement aggravates oral tongue squamous carcinoma
Authors: duan Yangfang , wei Youchun , wang Yunxia 
Published: June 2022

Abstract
Background: Oral tongue squamous carcinoma(OTSC) is an extremely malignant tumor specifically characterized by CDK2-mediated cell cycle perturbation.However,the underlying mechanism is poorly understood. HuR,an ubiquitously expressed member of the embryonic lethal abnormal vision family, participated in various malignent cancer. Therefore, this study aimed to explore the relationship of HuR and CDK2 in OTSC. Materials and methods: SCC25 cell line was sellected in vitro assay for the impact of HuR knockdown on tumor proliferation or CDK2 expression. IHC or mRNA levels of HuR and CDK2 expression were evaluated in malignent or benign lession tissue. Student’s t-test is used for two-group comparisons, and the one-way ANOVA for multiple group comparisons.Results:HuR knockdown reduced SCC25 proliferation, led to cell cycle arrest and dampened the colony formation. Mechanismly, HuR promoted CDK2 translation through binding to 3’untranslated regions. The luciferase activity assay futher authenticated the ARE-mediated HuR regulation on CDK2. Moreover, IHC results indicated that HuR expression exhibited progessive increase in the cases of pathological grade, accompanied by more cytoplasm distribution.Clinal datas demonstrated that the higher expression of HuR and CDK2 indicated poor prognosis and both had positive correlation. Conclutions: our study provides a compelling role of HuR in controlling the progression of OTSC by regulating CDK2 dependent cell cycle. These findings may provide a new therapeutic target for OTSC.
Detailed functional results after bladder-preserving surgery and high-dose-rate brachytherapy in pediatric bladder/prostate rhabdomyosarcoma
Authors: Ellerkamp Verena , Schmidt Andreas , Warmann Steven W , Eckert Franziska , Schaefer Juergen , Paulsen Frank , Fuchs Joerg 
Published: June 2022

Abstract
Purpose: In pediatric bladder/prostate-rhabdomyosarcoma, the rate of bladder preservation after neoadjuvant chemotherapy is high, with an excellent oncological outcome. Information about functional urological long-term outcomes is rare.Methods: Data of all patients who had undergone bladder-preserving surgery with or without brachytherapy at our institution between 2009 and 2020 were analyzed retrospectively.Detailed urological function was assessed focusing on age-related continence, bladder capacity and urodynamic findings.Results: We identified 40 patients, median age at surgery of 27 months (range 9-191), and 32 patients additionally received postoperative high-dose-rate brachytherapy. The median follow-up was 32.5 months (range 6-125). The bladder capacity increased from median 66.7% (21.1-180) of expected bladder capacity related to age 3 months after surgery to 87.4% (58.1-181.8) 9 months after surgery. In the group of aged >6-year-old, continence was 94% (83% with brachytherapy, 100% without brachytherapy). Erectile function was normal in 92% (90 % with brachytherapy, 100% without brachytherapy). Bladder capacity was more than 65% expected bladder capacity related to age in 70% (60% with brachytherapy, 86% without brachytherapy). 65% of all patients need neither anticholinergic drugs nor low-dose antibiotics (63% with brachytherapy, 71% without brachytherapy).Conclusions: Bladder preservation with good functional outcome can be achieved in localized bladder/prostate-rhabdomyosarcoma. In selected cases, supportive brachytherapy additionally contributes to an improvement in the oncological outcome with calculable risks for bladder and erectile function. Careful urological aftercare should be a fixed priority after oncological follow-ups.
Recent Advances in Biological Active Sulfonamide based Hybrid
Compounds Part A: Two-Component Sulfonamide Hybrids
Authors: Ghomashi Reihane , Ghomashi Shakila , Aghaei Hamidreza , Massah Ahmad Reza 
Published: June 2022

Abstract:
Sulfonamides constitute an important class of drugs, with many types of pharmacological agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic, hypoglycemic, antithyroid, antitumor, and anti-neuropathic pain activities. The sulfonamides have the general formula R-SO2NHR', in which the functional group is bound to an aromatic, heterocycle, aliphatic, and so on. The nature of the R and R' moiety is variable, starting with hydrogen and ranging to a variety of moieties incorporating organic compounds such as coumarin, isoxazole, tetrazole, pyrazole, pyrrole, and so many other pharmaceutical active scaffolds that lead to a considerable range of hybrids named as sulfonamide hybrids. Part A of this review presents the most recent advances in designing and developing two-component sulfonamide hybrids containing coumarin, indole, quinoline, isoquinoline, chalcone, pyrazole/pyrazoline, quinazoline, pyrimidine, thiazole, benzothiazole, and pyridine between 2015 and 2020. Specifically, the authors review the scientific reports on the synthesis and biological activity of this kind of hybrid agent.
Obesity, Hypertension, and Kidney Dysfunction: Mechanical Links
Authors: Öksüz Merve , Göbel Pınar 
Published: June 2022

Abstract:
Obesity is a risk factor for many diseases, including cardiovascular disease (CVD),
gastrointestinal disorders, type 2 diabetes (T2DM), joint and muscle disorders, respiratory problems,
and psychological problems that can significantly affect daily life. Hypertension affects
more than a quarter of the adult population in developed countries, constituting an important
health problem. In addition, its pathogenesis is not yet fully understood. Although hypertension
is mostly seen in overweight and obese people, it is usually more difficult to control in obese
people. It is well known that obesity is associated with the activation of both the sympathetic
nervous system and the renin-angiotensin system, contributing to hypertension. Kidney dysfunction
caused by obesity is a potential risk factor for cardiometabolic diseases, but the underlying
mechanism remains unclear. The purpose of this review study is to investigate the mechanical
links between obesity, hypertension, and kidney dysfunction.
Preparation of Silver Decorated Reduced Graphene Oxide Nanohybrid
for Effective Photocatalytic Degradation of Indigo Carmine Dye
Authors: Shetty Mohana Kikkeri Narasimha , Nayak Saurav Ramesh , Rajitha Kamalon , Madhusudhana Ambale Murthy , Swamy Ningappa Kumara , Hegde Mahesh Bhaskar 
Published: June 2022

Background:
Even though silver decorated reduced graphene oxide (Ag-rGO) shows maximum
absorptivity in the UV region, most of the research on the degradation of dyes using Ag-rGO is
in the visible region. Therefore the present work focused on the photocatalytic degradation of indigo
carmine (IC) dye in the presence of Ag-rGO as a catalyst by UV light irradiation.

Methods:
In this context, silver-decorated reduced graphene oxide hybrid material was fabricated and
explored its potential for the photocatalytic degradation of aqueous IC solution in the UV region. The
decoration of Ag nanoparticles on the surface of the rGO nanosheets is evidenced by TEM analysis.
The extent of mineralization of the dye was measured by estimating chemical oxygen demand (COD)
values before and after irradiation.

Results:
The synthesized Ag-rGO binary composites displayed excellent photocatalytic activity in 2
Χ 10-5 M IC concentration and 5mg catalyst loading. The optical absorption spectrum of Ag-rGO
showed that the energy band-gap was found to be 2.27 eV, which is significantly smaller compared to
the band-gap of GO. 5 mg of Ag-rGO was found to be an optimum quantity for the effective degradation
of IC dye. The degradation rate increases with the decrease in the concentration of the dye at alkaline
pH conditions. The photocatalytic efficiency was 92% for the second time.

Conclusion:
The impact of the enhanced reactive species generation was consistent with higher photocatalytic
dye degradation. The photocatalytic mechanism has been proposed and the hydroxyl radical
was found to be the reactive species responsible for the degradation of dye. The feasibility of reusing
the photocatalyst showed that the photocatalytic efficiency was very effective for the second time.
Medication Use and Clinical Outcomes by the Dutch Institute for Clinical Auditing Medicines Program: Quantitative Analysis
Authors: Ismail Rawa Kamaran , van Breeschoten Jesper , van der Flier Silvia , van Loosen Caspar , Pasmooij Anna Maria Gerdina , van Dartel Maaike , van den Eertwegh Alfons , de Boer Anthonius , Wouters Michel , Hilarius Doranne 
Published: June 2022

Background
The Dutch Institute for Clinical Auditing (DICA) Medicines Program was set up in September 2018 to evaluate expensive medicine use in daily practice in terms of real-world effectiveness using only existing data sources.

Objective
The aim of this study is to describe the potential of the addition of declaration data to quality registries to provide participating centers with benchmark information about the use of medicines and outcomes among patients.

Methods
A total of 3 national population-based registries were linked to clinical and financial data from the hospital pharmacy, the Dutch diagnosis treatment combinations information system including in-hospital activities, and survival data from health care insurers. The first results of the real-world data (RWD) linkage are presented using descriptive statistics to assess patient, tumor, and treatment characteristics. Time-to-next-treatment (TTNT) and overall survival (OS) were estimated using the Kaplan-Meier method.

Results
A total of 21 Dutch hospitals participated in the DICA Medicines Program, which included 7412 patients with colorectal cancer, 1981 patients with metastasized colon cancer, 3860 patients with lung cancer, 1253 patients with metastasized breast cancer, and 7564 patients with rheumatic disease. The data were used for hospital benchmarking to gain insights into medication use in specific patient populations, treatment information, clinical outcomes, and costs. Detailed treatment information (duration and treatment steps) led to insights into differences between hospitals in daily clinical practices. Furthermore, exploratory analyses on clinical outcomes (TTNT and OS) were possible.

Conclusions
The DICA Medicines Program shows that it is possible to gather and link RWD about medicines to 4 disease-specific population-based registries. Since these RWD became available with minimal registration burden and effort for hospitals, this method can be explored in other population-based registries to evaluate real-world efficacy.