bluuebunny/crossref_metadata_2025_split huggingface dataset:
Micro-RNA-215 and -375 regulate thymidylate synthase protein expression in pleural mesothelioma and mediate epithelial to mesenchymal transition
Authors: Napoli Francesca , Rapa Ida , Izzo Stefania , Rigutto Angelica , Libener Roberta , Riganti Chiara , Bironzo Paolo , Taulli Riccardo , Papotti Mauro , Volante Marco , Scagliotti Giorgio , Righi Luisella 
Published: April 2022

AbstractThe standard front-line treatment for pleural mesothelioma (PM) is pemetrexed-based chemotherapy, whose major target is thymidylate synthase (TS). In several cancer models, miR-215 and miR-375 have been shown to target TS, while information on these miRNAs in PM are still limited although suggest their role in epithelial to mesenchymal transition. Seventy-one consecutive PM tissues (4 biphasic, 7 sarcomatoid, and 60 epithelioid types) and 16 commercial and patient-derived PM cell lines were screened for TS, miR-215, and miR-375 expression. REN and 570B cells were selected for miR-215 and miR-375 transient transfections to test TS modulation. ZEB1 protein expression in tumor samples was also tested. Moreover, genetic profile was investigated by means of BAP1 and p53 immunohistochemistry. Expression of both miR-215 and miR-375 was significantly higher in epithelioid histotype. Furthermore, inverse correlation between TS protein and both miR-215 and miR-375 expression was found. Efficiently transfected REN and 570B cell lines overexpressing miR-215 and miR-375 showed decreased TS protein levels. Epithelioid PM with a mesenchymal component highlighted by reticulin stain showed significantly higher TS and ZEB1 protein and lower miRNA expression. A better survival was recorded for BAP1 lost/TS low cases. Our data indicate that miR-215 and miR-375 are involved in TS regulation as well as in epithelial-to-mesenchymal transition in PM.
A decisive bridge between innate immunity and the pathognomonic morphological characteristics of type 1 diabetes demonstrated by instillation of heat-inactivated bacteria in the pancreatic duct of rats
Authors: Angie Tegehall , Sofie Ingvast , Åsa Melhus , Oskar Skog , Olle Korsgren 
Published: April 2022

Abstract
Aims
Periductal inflammation and accumulation of granulocytes and monocytes in the periislet area and in the exocrine pancreas is observed within hours after instillation of heat-inactivated bacteria in the ductal compartment of the pancreas in healthy rats. The present investigation was undertaken to study how the acute inflammation developed over time.

Methods
Immunohistochemical evaluation of the immune response triggered by instillation of heat-inactivated bacteria in the ductal compartment in rats.

Results
After three weeks, the triggered inflammation had vanished and pancreases showed normal morphology. However, a distinct accumulation of both CD4+ and CD8+ T cells within and adjacent to affected islets was found in one-third of the rats instilled with heat-inactivated E. faecalis, mimicking the insulitis seen at onset of human T1D. As in T1D, this insulitis affected a minority of islets and only certain lobes of the pancreases. Notably, a fraction of the T cells expressed the CD103 antigen, mirroring the recently reported presence of tissue resident memory T cells in the insulitis in humans with recent onset T1D.

Conclusions
The results presented unravel a previously unknown interplay between innate and acquired immunity in the formation of immunopathological events indistinguishable from those described in humans with recent onset T1D.
Clinical parameters among patients in Japan with anemia and non-dialysis-dependent chronic kidney disease with and without diabetes mellitus who received roxadustat
Authors: Akizawa Tadao , Tanaka-Amino Keiko , Otsuka Tetsuro , Yamaguchi Yusuke 
Published: April 2022

Abstract
Background
Roxadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor for treating anemia of chronic kidney disease (CKD). This post hoc analysis of a Japanese, open-label, partially randomized, phase 3 study in patients with non-dialysis-dependent (NDD) CKD evaluated disease state–related parameters among patients with and without diabetes mellitus who received roxadustat. In the 1517-CL-0310 study (NCT02988973), roxadustat was noninferior to darbepoetin alfa for change in average hemoglobin levels at Weeks 18–24 from baseline who received roxadustat.

Methods
Patients enrolled in the 1517-CL-0310 study who received roxadustat were included in this post hoc analysis. Hematologic (hemoglobin, reticulocyte/erythrocyte ratio, mean corpuscular volume [MCV], and mean corpuscular hemoglobin [MCH]), iron-related (ferritin, total iron-binding capacity, transferrin, ceruloplasmin, and hepcidin), metabolic (HbA1c, glycated albumin, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol), and renal (eGFR) parameters were summarized descriptively by visit through Week 52.

Results
Among 201 included patients, 105 (52.2%) and 96 (47.8%) were in the Diabetes and No Diabetes subgroups, respectively. There were no clinically meaningful differences through Week 52 for most hematologic, iron-related, metabolic, or renal parameters between patients in the Diabetes and No Diabetes subgroups. MCV and MCH remained lower and HbA1c and glycated albumin remained higher in patients in the Diabetes subgroup through Week 52. Both subgroups experienced a similar benefit from roxadustat in maintaining hemoglobin levels in the target range of 10–12 g/dL.

Conclusion
Roxadustat maintained hemoglobin levels in the target range with similar clinical parameters irrespective of diabetes mellitus presence at baseline.
Women with short survival after diagnosis of metastatic breast cancer: a population-based registry study
Authors: Boman Caroline , Edman Kessler Luisa , Bergh Jonas , Matikas Alexios , Foukakis Theodoros 
Published: April 2022

Abstract
Purpose
Despite therapeutic advances, overall survival of metastatic breast cancer (MBC) at the population level has seen little improvement over the past decades. Aggressive tumor biology or delay in access to cancer care might be contributing factors. With this retrospective population-based study we aimed to quantify and characterize patients with very short survival time following MBC diagnosis.

Methods
Women diagnosed with MBC between Jan 1st, 2005 and Dec 31st, 2016 were identified using the population-based Stockholm–Gotland breast cancer registry. Data regarding demographic and clinicopathological characteristics, survival, and treatment were extracted retrospectively from the registry and from patient charts. Patients who died within 90 days following diagnosis of MBC were identified and their characteristics were compared with all other patients diagnosed with MBC during the same period.

Results
Between 2005 and 2016, 3124 patients were diagnosed with MBC, of whom 498 (16.2%) died within 90 days of diagnosis. Nearly half (N = 233) did not receive any antitumoral treatment. Patients with short survival were older (p < 0.001), had higher primary tumor grade (p < 0.001), higher clinical stage at primary diagnosis (p = 0.002), and more often estrogen receptor (ER)-negative breast cancer (p < 0.001). Visceral metastases were more frequent (p < 0.001) and patients with short survival received adjuvant chemotherapy (p < 0.001) to a lesser extent compared to patients with a better prognosis. In multivariable analysis older age, time period of diagnosis, metastasis site, adjuvant chemotherapy, and primary tumor grade were independent predictors for short survival, whereas ER status was not.

Conclusion
Nearly one out of six patients with MBC survive less than 3 months after diagnosis. Our findings demonstrate a different spectrum of MBC at population level and can potentially inform on individualized follow-up strategies and treatment algorithms.
Digitalisation and accounting language games in organisational contexts
Authors: Ruggeri Daniela , Leotta Antonio , Rizza Carmela 
Published: April 2022

AbstractThe ambition of digitalisation to create centralised knowledge for all organisational actors may lead to the risk of de-contextualising that knowledge from the situation in which the information was generated, neglecting the specificities of local organisational contexts. To prevent such risk, digitalisation should promote the spread of a common language between its users who share rules and principles that lead to the same meanings. We refer to the concept of the language game to study how accounting reports receive meanings according to their use, and thereby how the use of accounting language helps in managing the specifics of organisational contexts. Considering complex organisations where different local accounting language games coexist, management accounting studies on digitalisation fail to explain how digital technology can promote the combination of those language games.The present study aims to answer the question of how digitalisation, promoting a global accounting language game, favours the combination of the accounting language games arising from local organisational contexts.This question is addressed by examining the case of the performance measurement of the new product development process in a multidivisional company. The case evidence highlights how a digital platform, promoting a corporate accounting language game for the whole organisation, favoured the combination of divisional accounting language games.The paper points out how digitalisation affects the boundaries between local and global accounting language games in the production of knowledge for decision-making. Also, the paper shows how digital technology is beneficial only when it does not compromise interactions between the different organisational contexts.
Evaluation of Wear Measurement with Radioactive Isotopes for DLC Coatings Affected by Abrasive Particles
Authors: Zellhofer Manuel , Jech Martin , Badisch Ewald , Ditrói Ferenc , Kübler Andreas , Mayrhofer Paul Heinz 
Published: April 2022

AbstractDiamond-like carbon (DLC) coatings protect engine parts from wear and provide low-friction. Unfortunately, the nature of DLC coatings does not allow progressing wear measurement using conventional methods. Therefore, we applied a radioactive isotope-based wear measurement method (RIC method). A tribometer with oscillating contact and one with sliding contact were used to provide different loading conditions. The RIC method was evaluated for DLC coatings, and the DLC wear was investigated regarding the presence of abrasive particles. The results indicate that an increase in abrasive particle concentration leads to an increase of DLC wear rate and a decrease in usage-time until wear-off.
Non-monotonic Dynamics in the Onset of Frictional Slip
Authors: Farain Kasra , Bonn Daniel 
Published: April 2022

AbstractThe transition from static to dynamic friction is often described as a fracture instability. However, studies on slow sliding processes aimed at understanding frictional instabilities and earthquakes report slow friction transients that are usually explained by empirical rate-and-state formulations. We perform very slow ($$\sim$$
∼
nm/s) macroscopic-scale sliding experiments and show that the onset of frictional slip is governed by continuous non-monotonic dynamics originating from a competition between contact aging and shear-induced rejuvenation. This allows to describe both our non-monotonic dynamics and the simpler rate-and-state transients with a single evolution equation.
Evaluation of double faced transverse preputial (onlay) island flap for hypospadias repair in pediatrics: a randomized controlled study
Authors: Daboos Mohammad , Hefney Khalid , Abdelhafez Mahmoud Muhammad , Salama Ahmed , Mohammed Yousef , Hussein Mohammed , Abdelmaboud Mohamed , Hussein Tharwat , Ashour Yasser , Gouda Samir 
Published: April 2022

Abstract
Background
The preputial onlay island flap technique has been popularized for hypospadias repair as a result of offering a consistent combination of acceptable functional and cosmetic results. Like other techniques, urethrocutaneous fistulae and stricture continues to be the most common complications, in addition to other complications, which could be attributed to the compromise in flaps vascularity. Some authors describe a technique that resolves some of these problems by combining the unique benefits of the double faced preputial flaps. The aim of this study:- to evaluate double faced preputial onlay island flap technique for complications rate, outcomes of surgical procedure, and cosmetic results in comparison to transverse inner preputial flap technique.

Patients and methods
This was a prospective randomized controlled study that included 68 patients with anterior, mid-penile, and posterior penile hypospadias, with shallow and narrow urethral plate of size less than 6 mm, who underwent single-stage repair using preputial flaps, conducted at the department of pediatric surgery (Al-Azhar University, Cairo, Egypt), between May 2019 and October 2021, to evaluate double faced transverse preputial onlay island flap technique. Thirty-four patients underwent double faced transverse preputial onlay island flap (group A) and another 34 patients underwent inner transverse preputial onlay island flap (control group) (group B). The follow-up period ranged from 12 to 26 months.

Results
The overall complication rate was 20.5% (14 of 68 children). Complications developed in 5 cases (14.7%) in group A who underwent double face onlay island flap (2 glannular dehiscence, 1 penile rotation, 1 fistula, and 1 diverticulum), as opposed to 9 patients in group B (26.4%) who underwent transverse inner preputial flap (3 developed glannular dehiscence, 2 skin flap necrosis, 3 fistulae, and 1 diverticulum). After management of the complications, all patients had good surgical outcomes with satisfactory cosmetic results.

Conclusion
Double faced transverse preputial onlay island flap is an alternative option to reconstruct narrow urethral plate hypospadias. So that double faced transverse preputial onlay island flap technique appears to achieve satisfactory surgical outcomes with lower complication rate.
Deep Brain Stimulation for Parkinson’s Disease: Why Earlier Use Makes Shared Decision Making Important
Authors: Montemayor Jaime , Sarva Harini , Kelly-Blake Karen , Cabrera Laura Y. 
Published: April 2022

Abstract
Introduction
As deep brain stimulation (DBS) has shifted to being used earlier during Parkinson’s disease (PD), data is lacking regarding patient specific attitudes, preferences, and factors which may influence the timing of and decision to proceed with DBS in the United States. This study aims to identify and compare attitudes and preferences regarding the earlier use of DBS in Parkinson’s patients who have and have not undergone DBS.

Methods
We developed an online survey concerning attitudes about DBS and its timing in PD. The survey was distributed nationally in the United States via the Michael J. Fox Foundation Trial Finder, the American Parkinson Disease Association flyers, and as a link on the Parkinson Alliance website. Differences in responses between PD DBS and non-DBS patients were assessed.

Results
A total of 445 patients with PD met eligibility criteria for the survey of which 160 self-identified as having undergone DBS. Fifty-five percent (n = 124) of non-DBS patients believed that DBS for PD should only be considered after all medication options have been tried. Patients favoring early DBS had fewer concerns regarding the surgery than those favoring later DBS.

Conclusion
Our findings highlight a variety of important considerations and concerns patients have regarding DBS and its timing. These viewpoints are important aspects of shared decision-making, as they help to identify patients’ preferences, values, and goals, which should enable providers to better navigate, with their patients, the decision path for therapeutic options to consider.
Study on the effect of raindrops on the dynamic stall of a NACA-0012 airfoil
Authors: Sheidani Armin , Salavatidezfouli Sajad , Schito Paolo 
Published: April 2022

AbstractIn this study the pure effect of raindrops on dynamic stall of a pitching airfoil has been investigated. The simulation was performed at Reynolds number of $${10}^{6}$$

10

6

with raindrop diameter equal to $${10}^{-5}\text{m}$$

10

-
5

m

. A couple of multiphase models based on Eulerian and Lagrangian frames of reference have been implemented to simulate the raindrops. In the first step the accuracy of each multiphase model has been appraised. As a result, the Lagrangian multiphase model, which is called Discrete Phase Model, has been proven to be of better accuracy. It has been concluded that in general raindrops has negative effects on the lift coefficient of the pitching airfoil. In addition, a lead in aerodynamic phenomena has been observed due to the presence of water drops. This phenomenon has also been observed in the formation and separation of Leading Edge and Trailing Edge vortices which come to existence in advance of the dry case. Finally, it has been illustrated that the main effect of raindrops is on the phase of force oscillation rather than the force amplitude.
Special zeta Mahler functions
Authors: Ringeling Berend 
Published: April 2022

AbstractWe study the zeta Mahler function (ZMF, also zeta Mahler measure), which is closely related to the Mahler measure. Here we discuss a family of ZMFs attached to the Laurent polynomials $$k + (x_1 + x_1^{-1}) \cdots \left( x_r + x_r^{-1}\right) $$

k
+

(

x
1

+

x
1

-
1

)

⋯

x
r

+

x
r

-
1

, where k is real. We give explicit formulae, present examples and establish properties for these ZMFs, such as an RH-type phenomenon. Further, we explore connections with the Mahler measure.
Capillary Performance of Nanoporous Aluminum Braided Wicks Prepared by Anodic Oxidation
Authors: Gao Fei , Lu Longsheng , Mei Xiaokang , Yu Yu-Xiang , Chai Shitong , Shen Yang , Xie Yingxi 
Published: April 2022

AbstractWith the rapid development of two-phase heat exchangers, the further improvement of the capillary performance of their internal wick faces a great challenge. As an important technology in the surface treatment of aluminum alloys, anodic oxidation has been widely used to develop various functional nanostructures. In this study, nanopores with diameters of 30–40 nm were fabricated on the surface of aluminum fibers through anodic oxidation under an oxalic acid system. Results showed that anodizing increased the specific surface area of the aluminum braid by 163 times, and changed its surface wettability from hydrophobic to superhydrophilic. A significant reduction in the effective capillary radius can substantially increase the capillary force of aluminum braids on the basis of capillary theory. Therefore, the nanoporous aluminum braids can be used as a novel wick in the vapor chamber to improve its capillary performance. Capillary rate-of-rise tests with ethanol and acetone were performed to characterize the capillary of this novel wick structure. Infrared thermal imaging was utilized to monitor the capillary rise of aluminum braided wicks. The capillary force of the anodized wicks was greater than that of a normal wick, and the maximum capillary rise height was 81 mm. The nanoporous aluminum braided wicks prepared by anodizing could be applied in heat transfer.
Psychodrama als Verfahren innerhalb der religionspsychologischen Praxis
Authors: Trettin Alexander 
Published: April 2022

ZusammenfassungDer Beitrag beschreibt, wie Psychodrama als Verfahren innerhalb der religionspsychologischen Praxis empirisch eingesetzt werden kann, um religiöse/spirituelle Strukturen sichtbar bzw. religiöse/spirituelle Phänomene begreifbar zu machen. Hierbei gilt es, Religiosität bzw. Spiritualität als therapeutische Ressource herauszuarbeiten. Im Artikel werden zudem die religionspsychologischen Anteile des Psychodramas skizziert, die schließlich in Überlegungen zum Ritual und zur Katharsis münden. Die psychodramatische Lesung des ‚Zauberbergs‘ von vier Freimaurern dient hierbei als Fallbeispiel für die praktische Anwendung.
Dynamical Impact of the Mekong River Plume in the South China Sea
Authors: Zeng Xiyuan , Bracco Annalisa , Tagklis Filippos 
Published: April 2022

AbstractNear the ocean surface, river plumes influence stratification, buoyancy and transport of tracers, nutrients and pollutants. The extent to which river plumes influence the overall circulation, however, is generally poorly constrained. This work focuses on the South China Sea (SCS) and quantifies the dynamical impacts of the Mekong River plume, which is bound to significantly change in strength and seasonality in the next 20 years if the construction of over hundred dams moves ahead as planned. The dynamic impact of the freshwater fluxes on the SCS circulation are quantified by comparing submesoscale permitting and mesoscale resolving simulations with and without riverine input between 2011 and 2016. In the summer and early fall, when the Mekong discharge is at its peak, the greater stratification causes a residual mesoscale circulation through enhanced baroclinic instability. The residual circulation is shaped as an eddy train of positive and negative vorticity. Submesoscale fronts are responsible for transporting the freshwater offshore, shifting eastward the development of the residual mesoscale circulation, and further strengthening the residual eddy train in the submesoscale permitting case. Overall, the northward transport near the surface is intensified in the presence of riverine input. The significance of the mesoscale‐induced and submesoscale‐induced transport associated with the river plume is especially important in the second half of the summer monsoon season, when primary productivity has a secondary maximum. Circulation changes, and therefore productivity changes, should be anticipated if human activities modify the intensity and seasonality of the Mekong River plume.
The Character and Changing Frequency of Extreme California Fire Weather
Authors: Prein Andreas F. , Coen Janice , Jaye Abby 
Published: April 2022

AbstractFive of California's 10 largest wildfires occurred in 2020, with the largest complex exceeding the previous largest by more than 100%. The year follows a decade containing extraordinary fire activity. Previous trend investigations focused on changes in human activities and atmospheric thermodynamics, while the impacts of changing atmospheric dynamics are largely unknown. Here, we identify weather types (WTs) associated with historically large daily burned areas in eight Californian regions. These WTs characterize dominant fire weather regimes varying in fire behavior types (plume‐driven vs. wind‐driven fires) and seasonality. Most of the strongly large‐scale forced WTs such as Santa Ana and Diablo events increased in frequency during the 20th century particularly in the San Diego and Bay Area regions. These changes are likely not anthropogenically caused and the frequency of such events is projected to decrease under continuing climate change. However, significant future increases are found for WTs associated with thermal‐low‐pressure systems along the California coast and in the Sierra west region. These increases in southern California are mainly due to increasing greenhouse‐gas forcing and arise from the larger ocean‐land temperature gradient while aerosol forcing changes are driving most of the increased frequency in central and northern California due to a reduction of relative humidity over land and a strengthening of low‐pressure anomalies over the coast. These WT frequency changes could permit more weather favorable for large fire growth in summer and less in fall, further enhancing the risk of catastrophic fires due to hotter and drier summers in future climates.