bluuebunny/crossref_metadata_2025_split huggingface dataset:
A-21 Examining Suicidal Ideation in Adolescents Who Have Sustained Concussions
Authors: Iverson G L , Gaudet C E , Karr J E 
Published: July 2022

Abstract
Purpose: To identify correlates of suicidal ideation in adolescents who reported experiencing a concussion in the past year using multivariable models. Methods: This study analyzed data from the 2019 Youth Behavior Risk Survey (YBRS) that included 13,677 participants, of which 1754 (12.8%) reported experiencing a concussion in the past year. Binary logistic regressions were conducted to assess the association between modifiable stress factors (e.g., insufficient sleep, bullying, poor grades, binge drinking, marijuana use, and illicit drug use) and suicidal ideation. Results: Among adolescents who experienced a concussion in the past year, 24.7% also reported suicidal ideation in the past year (31.2% of girls and 19.4% of boys). In multivariable models, only depression (OR = 9.27 for girls and 9.50 for boys) and being bullied (OR = 2.37 for girls and 2.29 for boys) showed associations with suicidal ideation in both girls and boys. Among girls, illicit drug use (OR = 2.80) and current marijuana use (OR = 2.47) also showed an association with suicidal ideation. The number of modifiable stressors was strongly associated with reporting suicidal ideation in the total sample, as follows: 0 stressors = 9.7%, 1 stressor = 21.6%, 2 stressors = 37.2%, 3 stressors = 35.5%, and 4 or more stressors = 52.8%. Conclusions: A sizeable percentage of adolescents who experienced a concussion in the past year also endorsed suicidal ideation in the past year. In multivariable models, depression showed the strongest association with endorsement of suicidal ideation in both girls and boys. A greater number of modifiable stressors was strongly associated with reporting suicidal ideation.
A-27 Stakeholder Attitudes and Perceptions regarding Concussion in Athletes with Intellectual Disabilities
Authors: Madden M , McGill C , Klima D W 
Published: July 2022

Abstract
Purpose: Sports-related concussion (SRC) is a public health concern with particular complexities that occur in Special Olympics (SO) because injuries and acute identification tools are not well understood for athletes with intellectual disabilities (ID). The purpose of this study was to explore current education, recognition and management strategies among coaches and caregivers in Special Olympics North America (SONA). Methods: A descriptive survey via the Qualtrics platform was distributed to coaches and caregivers in SONA through their electronic newsletter. Analyses included descriptive statistics and Chi square frequencies. Results: Out of a total 103 returned surveys, 77 were fully completed by coaches (83%) and caregivers (17%) from 10 states. The majority of coaches (91%) completed concussion education within the last two years. Sixty-one percent of coaches reported coaching a contact or high concussion-risk sport; moreover, these coaches were more likely to recognize injuries (p = 0.02). Forty-three percent of coaches disclosed that concussions may be underreported in SO, but 72.5% agreed that concussion are serious injuries. Although coaches generally felt prepared to recognize (95%) and remove (95%) athletes with SRC symptoms, management strategies to recognize (34%) or treat (39%) SRC athletes with ID was low. Coaches described feeling less confident to manage these return-to-play decisions following injury (76%). Non-healthcare professionals were first responders for injuries during non-competition (68%) events and competition (14%). Conclusions: Coaches involved in SO should complete tailored concussion education training to enhance recognition and management strategies. Future initiatives should target curriculum adapted to communication needs of athletes with ID.
A-40 Age, Head-Injury Exposure, And Neurocognitive Functioning Among Older NFL Retirees
Authors: Schaffert J , LoBue C , Wilmoth K , Didehbani D , Hart J , Cullum C M 
Published: July 2022

Abstract
Purpose: Prior research suggests that head-injury exposure (HIE) may interact with age to reduce neurocognitive functioning in former football players, though it remains unclear if other variables may play a role. As such, we evaluated this interaction in older NFL retirees with and without potential covariates. Methods: Participants included 48 older NFL retirees (aged 50–79, M = 65, SD = 7.6). Twenty-seven were cognitively normal, 21 had mild cognitive impairment, and 5 had dementia. HIE variables included number of concussions (Range = 0–18, M = 5.6, SD = 4.5), concussions with loss of consciousness (Range = 0–13, M = 2.2, SD = 2.4), and NFL games played (Range = 15–224, M = 115.1, SD = 50.1). Composite normative T-scores of executive functioning/attention/speed (EFAS; Range = 31.3–62.9, M = 49.6, SD = 6.9), language (Range = 32.4–64.2, M = 47.3, SD = 7.6), and memory (Range = 26.9–65.8, M = 44.5, SD = 9.4) were derived from neuropsychological data. Multiple regressions [p-value at 0.05 with bootstrapping (2000 iterations)] analyzed the relationship between age, HIE, and neuropsychological composites. Post-hoc analyses were conducted with additional covariates: depressive symptoms (Beck Depression Inventory-II), cerebrovascular risk factors, and cognitive diagnosis. Results: Age (t = −2.394, p = 0.021) and games played (t = −2.311, p = 0.018) predicted lower memory functioning. An interaction between age and concussions (t = −2.199, p = 0.033) suggested that older retirees with more concussions had a lower EFAS composite. However, results were not significant when including covariates in the model (p’s &gt; 0.05). Conclusions: HIE was not significantly related to later-in-life neurocognitive functioning in older NFL retirees when accounting for depressive symptoms, cognitive diagnosis, and cerebrovascular risk factors, highlighting the importance of including additional factors known to impact cognition when assessing this relationship. Findings regarding cumulative HIE and cognition are mixed, and additional study is needed.
A-42 Emotional Health and Recovery in Adolescent and Young Adult Athletes Who Experienced a Sports-Related Concussion
Authors: Shaba A , Pardini J , Musial D , Sandoval M 
Published: July 2022

Abstract
Purpose: This quantitative study explored the relation between mood and recovery time in. athletes with sports-related concussion. Methods: Deidentified data were extracted from an existing database of an outpatient concussion clinic. Subjects (n = 89; 39.3% female; mean age = 15.57) were included if they were ages 13 to 25, sustained concussion while participating in sport, were assessed within 10 days of injury, and had no evidence of structural brain injury. Total scores from the Generalized Anxiety Disorder-7 (GAD-7) and the Patient Health Questionnaire-9 (PHQ-9) were predictor variables. Recovery time was defined as time from injury to return-to-play. Results: Mean recovery time was consistent with prior research (24.41 days, SD = 16.36). Anxiety and depression total scores considered together predicted recovery time (multiple linear regression; F(2,86) = 8.84, p &lt; 0.001). Anxiety did not predict recovery time when controlling for depression. Depression (mean total = 3.78, SD = 3.41) predicted recovery time when controlling for anxiety, (standardized ß = 0.44, t = 3.34, p = 0.001). Conclusions: The GAD-7 and PHQ-9 are easy-to-use mood screening instruments that do not require a considerable amount of time to administer. Higher scores on the PHQ-9 and the combination of both instruments when administered within 10 days of injury were related to longer recovery times in athletes. For every 3.41 points that the total PHQ-9 score increased, recovery time increased by approximately 7 days. This underscores the importance of examining mood state as part of a comprehensive assessment after sport-related concussion.
A-46 High School Soccer and Risk for Mental Health Outcomes in Adulthood: A National Longitudinal Study
Authors: Terry D P , Kissinger-Knox A , Iverson G L 
Published: July 2022

Abstract
Purpose: There is concern that participation in contact sports during youth might confer risk for later in life mental health problems. We examined whether playing high school soccer was associated with higher rates of depression, anxiety, and suicidality in early to middle adulthood. Methods: The National Longitudinal Study of Adolescent to Adult Health (“Add Health”) database was analyzed at Wave I (n = 6503; median age = 15), Wave III (median age = 22), Wave IV (median age = 29), and Wave V (n = 4196; median age = 38). We compared those who played soccer to those who did not play contact sports on mental health outcomes. Results: There were 221 participants who played high school soccer (102 men and 119 women) compared to 2388 who denied participation in contact sports (784 men and 1604 women). During their late 30s, approximately 17.4% of men and 31.0% of women reported a lifetime history of depression, and 15.6% of men and 28.8% of women reported a lifetime history of anxiety. Suicidal ideation, in the past year, was reported by 7.1% of men and 6.8% of women. When comparing those who played soccer to those who did not, there were no statistically significant differences in the proportions who had a lifetime diagnosis of depression or anxiety, or suicidal ideation in the past year, during Waves III, IV, or V of data collection (p-values&gt;0.05). Conclusions: Adults who played high school soccer did not have greater mental health problems at three different time points spanning more than 20 years after high school.
A-49 Sideline Concussion Assessment Tool symptoms predict poorer mental health outcomes in college athletes
Authors: Varkovetski M , Naidu D , Mosewich A , Mrazik M 
Published: July 2022

Abstract
Purpose: Assessment of emotional functioning is essential in sports-related concussion (SRC) management. This study investigated the prediction of mental health outcomes from the SCAT-3 Symptom Scale. Methods: Canadian university athletes who compete in contact sports participated in a large-scale study (Active Rehabilitation). A total of 235 participants (males = 67%) completed the Brief Symptom Inventory (BSI), Quality of Life Scale (QOLS), and Sideline Concussion Assessment Tool, 3rd edition (SCAT). Step-wise regression analysis using demographic variables (gender, age, history of Learning Disability, history of ADHD, diagnosis of psychiatric condition) and psychological symptoms from the SCAT were used as predictors for the BSI (Depression and Anxiety) and QOLS (Depression and Anxiety). Results: Regression analysis revealed female gender, previous psychiatric diagnosis and Nervousness (SCAT) significantly predicted higher scores on the Depression subscales of BSI (R2 = 0.21, F1,231 = 20.3, p &lt; 0.001) and Quality of Life (R2 = 0.21, F1,231 = 18.0, p &lt; 0.001). Female gender, previous psychiatric diagnosis, Nervousness and Irritability predicted higher scores on both the Anxiety subscales of the BSI (R2 = 0.23, F1,230 = 16.9, p &lt; 0.001) and Quality of Life (R2 = 0.26, F1,230 = 20.2, p &lt; 0.001). Contrary to other findings, history of concussion was not significantly predictive of higher Depression and/or Anxiety scores (although there was a trend between number of concussions and higher symptom report). Conclusions: SCAT symptoms may capture heightened emotional symptom report with more robust scales measuring emotional functioning. In contrast, concussion history did not predict emotional symptoms, a finding contrary to published literature.
The dollar enablers and panhandlers: US capitalist power and the origins of the financialisation at the periphery
Authors: Bastos Pedro Paulo Zahluth , Young Victor 
Published: July 2022

Abstract
The article discusses the political economy of financialisation in developing countries, defending that US power was crucial to driving it, while the indebted dependent states acted not only as dollar panhandlers but also as dollar enablers. To avoid excessively ‘outside-in’ apprehensions of US power in the capitalist bloc, we debate interpretations that use the concepts of structural power and internationalisation of the state to highlight some political effects of increasing international economic integration and capitalist wealth interpenetration. The theoretical discussion sets the stage for the presentation of declassified documents that illustrate how financial leverage has combined with some converging capitalist goals to entrench neoliberalism and financialisation in the Global North and the Global South. Our contribution serves to caution heterodox economists not to frame national autonomy only in terms of policy analysis, urging them to mobilise critical theory to imagine beyond the established frameworks for action.
Evaluating Chemical Cues Associated withHalyomorpha halysToward Enhanced Sensitivity of Surveillance forTrissolcus japonicus
Authors: Dyer J E , Talamas E J , Leskey T C , Bergh J C 
Published: July 2022

AbstractIn Asia, Trissolcus japonicus (Ashmead) (Hymenoptera: Scelionidae) is the predominant egg parasitoid of the brown marmorated stink bug, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae). Detections of adventive T. japonicus populations in North America since 2014, where invasive H. halys populations have impacted various specialty crops, spurred surveillance efforts to track T. japonicus, and yellow sticky cards (YSC) deployed in H. halys host trees have proven effective for this purpose. While T. japonicus exhibits positive behavioral responses to several olfactory stimuli associated with H. halys under laboratory conditions, these have not been evaluated for their potential utility to enhance surveillance of T. japonicus in the field. In northwestern Virginia, where both H. halys and T. japonicus are well-established, we examined the effect of baiting tree of heaven, Ailanthus altissima (Mill.) Swingle (Sapindales: Simaroubaceae), with lures containing the H. halys aggregation pheromone and pheromone synergist on the abundance of H. halys egg masses and captures of T. japonicus in YSC. We also assessed the effect of baiting YSC with newly-laid H. halys egg masses or n-tridecane, a component of H. halys tarsal prints, on T. japonicus captures. Destructive sampling of pheromone-baited and nonbaited trees revealed no significant differences in H. halys egg mass abundance on foliage. Similarly, YSC deployed in pheromone-baited and nonbaited trees showed no significant differences in T. japonicus captures. Moreover, YSC augmented with H. halys egg masses or n-tridecane showed no increase in T. japonicus captures compared with nonbaited controls. The implications for surveillance of adventive T. japonicus are discussed.
A Horticultural Cuticle Supplement Can Impact Quality Characters andDrosophila suzukiiDamage of Several Small and Stone Fruit
Authors: Tait Gabriella , Mermer Serhan , Chave Ryan D B , Rossi-Stacconi Marco Valerio , Kaiser Clive , Walton Vaughn M 
Published: July 2022

AbstractSurface wax and other cellular building blocks play an important role in preserving fruit integrity from biotic and abiotic adversities. Huge energy expenses are made by plants to place these protective compounds onto the epidermal cuticle. Sprayable plant and fruit coatings have been developed to protect plant tissues from environmental stresses, pathogens, and arthropods. The aim of this study was to determine if an experimental cuticle supplement containing waxes can affect fruit quality parameters such as firmness and size of various crops. Cherry, blueberry, and winegrape plants treated with the cuticle supplement showed significant increases in berry firmness ranging from 4.6 to 11.6%. No quality benefits were however observed on blackberry. Cuticle supplement applications did not significantly affect berry size. Laboratory trials resulted in a 54% mean reduction in a model pest insect i.e., Drosophila suzukii egg laying on blueberry. Short-duration field trials over 72 ± 2 to 96 ± 2 h on commercial-standard blueberry bushes resulted in 50–93.4% reductions of D. suzukii damage. Longer-term field trials on cherry and blueberry challenged with egg-laying D. suzukii showed reductions of damage ranging from 45 to 95%, up to 30 d after initial cuticle supplement applications. These results indicate that the cuticle supplement significantly alters berry firmness and reduces D. suzukii damage under commercial production conditions. One factor that may contribute to this reduction includes improved fruit quality parameters. The current work serves to expand integrated pest management options to control D. suzukii populations in commercial field settings.
The secret life of insect-associated microbes and how they shape insect–plant interactions
Authors: Coolen Silvia , Rogowska-van der Molen Magda , Welte Cornelia U 
Published: July 2022

AbstractInsects are associated with a plethora of different microbes of which we are only starting to understand their role in shaping insect–plant interactions. Besides directly benefitting from symbiotic microbial metabolism, insects obtain and transmit microbes within their environment, making them ideal vectors and potential beneficiaries of plant diseases and microbes that alter plant defenses. To prevent damage, plants elicit stress-specific defenses to ward off insects and their microbiota. However, both insects and microbes harbor a wealth of adaptations that allow them to circumvent effective plant defense activation. In the past decades, it has become apparent that the enormous diversity and metabolic potential of insect-associated microbes may play a far more important role in shaping insect–plant interactions than previously anticipated. The latter may have implications for the development of sustainable pest control strategies. Therefore, this review sheds light on the current knowledge on multitrophic insect–microbe–plant interactions in a rapidly expanding field of research.
Pollen Alone or a Mixture of Pollen Types? Assessing Their Suitability for Mass Rearing of Neoseiulus cucumeris (Acari: Phytoseiidae) Over 20 Generations
Authors: Yazdanpanah Shima , Fathipour Yaghoub , Riahi Elham , Zalucki Myron P 
Published: July 2022

Abstract
The generalist predatory mite, Neoseiulus cucumeris (Oudemans) is known as one of the most effective natural enemies on many pests. This economically important biocontrol agent was reared for 20 generations on date palm and castor bean pollen as well as a mixture of pollen types, including date palm, castor bean, and almond. The performance of this predator was evaluated by comparing its life table parameters after different generations (G1–G20) fed on each diet in a laboratory at 25 ± 1°C, 60 ± 5% RH, and a photoperiod of 16:8 (L: D) h. The development time of the predator reared on all tested diets had no significant difference in G20. The intrinsic rate of increase (r) of N. cucumeris by feeding on the mixed pollen (0.197 day−1) was significantly higher than that on castor bean, or date palm pollen (0.146 or 0.152 day−1 in G1, respectively). Our results indicated that the predator’s performance was not affected by long-term feeding on the pollen diets, as well as there was no considerable difference between pollen alone and pollen mixture diets. Furthermore, mites reared on pollen diets had higher quality than those reared on natural prey, Tetranychus urticae Koch.
Skating the line between general wellness products and regulated devices: strategies and implications
Authors: Simon David A , Shachar Carmel , Cohen I Glenn 
Published: July 2022

Abstract
Health technology is advancing at a rapid clip, with many of these technologies appearing on consumer products like smartphones and tablets. Federal regulators have responded to these changes with a flexible approach that allows firms to manufacture a ‘general wellness product’ (‘GWP’) without being subject to regulation typically applied to ‘devices’ that diagnose or treat a disease or condition. Using currently available medical products and devices from across a spectrum of diseases, we describe how firms can use this existing regulatory framework to develop innovative products by ‘skating the line’ between mostly unregulated GWPs and regulated devices. On the one hand, we find that skating the line offers a variety of benefits, including potential improvements to product development, innovation, and patient access to medical technologies. On the other hand, we show that this technique has potential costs to patient safety, competition, and data sharing. Skating the regulatory line between GWP and devices, in other words, offers important benefits but is not without risks. Any further regulatory action to address such risks should be careful to leave significant unregulated space for product development.
Docetaxel in combination with metformin enhances antitumour efficacy in metastatic breast carcinoma models: a promising cancer targeting based on PEGylated liposomes
Authors: Vakili-Ghartavol Roghayyeh , Mehrabian Amin , Mirzavi Farshad , Rezayat Seyed Mahdi , Mashreghi Mohammad , Farhoudi Leila , Kharrazi Sharmin , Sadri Kayvan , Jaafari Mahmoud Reza 
Published: July 2022

Abstract

Objectives
Metformin has been shown to kill cancer stem-like cells in genetically various types of breast carcinoma. With the aim to simultaneously eradicate the bulk population of tumour cells and the rare population of cancer stem-like cells in breast cancer tissues, we used the combination chemotherapy of docetaxel (DTX) with metformin (MET). Furthermore, we introduce an active loading method based on ammonium sulphate 250 mM (SA) for encapsulating docetaxel into liposomes.

Methods
Docetaxel and metformin encapsulated into PEGylated liposomes with two different methods based on remote or passive loading methods, respectively. The size and surface charge of the liposomes were characterized. DTX content in the nanoliposomes was measured by the high-performance liquid chromatography method. The drug release profiles were evaluated in phosphate-buffered dextrose 5% with the pH of 6.5 and 7.4. We examined the antitumour activity of Taxotere (TAX), and liposomal formulation of DTX and MET as a monotherapy or combination therapy. The biodistribution of liposomes was also investigated using 99mTc hexamethyl propylene amine oxime method in BALB/c mice bearing 4T1 breast carcinoma tumours.

Key findings
The final formulations were prepared according to the best physicochemical characteristics which were HSPC/mPEG2000-DSPE/Chol (DTX liposomes) and HSPC/DPPG/mPEG2000-DSPE/Chol (MET liposomes), at molar ratios of 85/5/10 and (55/5/5/35), respectively. In vivo experiments showed that when free or liposomal metformin used in combination with liposomal docetaxel, they prolonged median survival time (MST) from 31 in the control group to 46 days, which demonstrates their promising effects on the survival of the 4T1 breast carcinoma mice models. Moreover, combination therapies could significantly increase life span in comparison with phosphate-buffered saline (PBS) and Taxotere groups at the same dose. Furthermore, in the combination therapy study, treatment with DTX liposomes prepared by ammonium sulphate 250 mM buffer alone resulted in similar therapeutic efficacy to combination therapy. The biodistribution study exhibited significant accumulation of DTX liposomes in the tumours due to the Enhanced Permeability and Retention effect.

Conclusions
This study also showed that metformin-based combinatorial chemotherapies have superior efficacy versus their corresponding monotherapy counterparts at same doses. The findings confirm that liposomes based on ammonium sulphate 250 mM could be as a promising formulation for efficient DTX delivering and cancer targeting and therefore merit further investigations.