bluuebunny/crossref_metadata_2025_split huggingface dataset:
Re-interpretation of the mechanism of type 2 diabetes mellitus based on a framework of psychosomatic medicine: a real-world study
Authors: Min Wenjiao , Zhou Bo , Li Zhengyu , Tang Nie , Zhang Xu , Wang Jinxiang , Chen Yuexin , Zhou Yaling , A Ruhan , Tang Lei , Li Gang , Sun Xueli 
Published: November 2022

Abstract
Objective
Using bipolar disorder (BD) as a control, we explored the possible developmental process of impaired glucose metabolism rhythm.

Methods
In total, 441 subjects (77, 162, 134, 54, and 14 in the pre-diabetes [pre-DM], DM, BD, BD + pre-DM, and BD + DM groups, respectively) and 160 controls were included. All subjects were assessed using the Neuroticism Extraversion Openness Five-Factor Inventory (NEO-FFI). The hypothalamic-pituitary-adrenal (HPA) and hypothalamic–pituitary–thyroid (HPT) axes were measured.

Results
Cluster analysis showed that the BD, BD + DM, and DM groups were classified as the ‘disease group, the BD + pre-DM group as the ‘mixed period group’, and the pre-DM group as the ‘pre-disease group’. The conscientiousness factor scores of the NEO-FFI in the ‘disease group’ were higher than the norm but lower than the norm in the ‘pre-disease group’. The scores of neurotic factors in the ‘pre-disease’ and ‘mixed period’ groups were both significantly higher than that in the ‘disease group’ (corrected p < 0.001). The incidences of the abnormal HPA axis decreased gradually from the ‘pre-disease group’ to the ‘mixed period group’ then to the ‘disease group’, while those of the HPT axis slightly increased at first and then significantly decreased. The overall prediction rate of the multiple logistic regression model was 92.7%.

Conclusion
This study suggests that progression of pre-diabetes to DM is a continuous process from local abnormalities to rhythm disorder of glucose metabolism. This understanding can be applied to the whole course management and early intervention of DM and to the future development of optimised treatment based on rhythm regulation.

Trial registration
Clinical trial registration number: ChiCTR1800019064. Name of trial registration: Identify and the optimization of treatment for non-infectious chronic diseases under the “stress-dysrhythmia” theory hypothesis (Registration date: 24/10/2018). The full trial protocol can be accessed at the Chinese Clinical Trial Registry (http://www.chictr.org.cn/).
Oral hygiene and oral health behavior, periodontal complaints and oral health-related quality of life in pregnant women
Authors: Schröter Uwe , Ziebolz Dirk , Stepan Holger , Schmalz Gerhard 
Published: November 2022

Abstract
Objectives
This questionnaire-based cross-sectional study aimed in the evaluation of oral hygiene and oral health behavior, periodontal complaints and oral health-related quality of life (OHRQoL) in pregnant women in southwest-Saxony, Germany.

Materials and methods
Consecutive patients attending the clinics for Obstetrics and Gynecology, Heinrich-Braun-Klinikum Zwickau, Germany, were recruited in the years 2020 and 2021. The evaluation consisted of three parts: (I) dental and oral hygiene behavior, (II) periodontal complaints and (III) German short form of oral health impact profile (OHIP G14) to assess OHRQoL.

Results
853 out of 1056 participants were included in the study. The pregnant women reported that they have received information on oral health during pregnancy more often from gynecologists than from dentists. Slightly more than half of the participants (51.5%) rated to regularly undergo a professional tooth cleaning. Similarly, nearly half of the women stated to perform interdental cleaning (55.8%). The most common periodontal complaint was bleeding of the gums (45.4%). The OHIP G14 findings of all questions as well as sum scores showed a median of 0. Regression analysis revealed that regular professional tooth cleaning was a predictor of better OHRQoL (β – 0.698, CI95 0.049–1.299; p < 0.04).

Conclusion
Oral hygiene and oral health behavior of pregnant women in southwest-Saxony requires improvement. While the overall OHRQoL of the cohort was not reduced, professional tooth cleaning and thus professional preventive measures can support OHRQoL during pregnancy. Improved interdisciplinary oral health care concepts for pregnant women should be fostered. These concepts can also positively influence OHRQoL issues.
A haplotype-resolved genome assembly of the Nile rat facilitates exploration of the genetic basis of diabetes
Authors: Toh Huishi , Yang Chentao , Formenti Giulio , Raja Kalpana , Yan Lily , Tracey Alan , Chow William , Howe Kerstin , Bergeron Lucie A. , Zhang Guojie , Haase Bettina , Mountcastle Jacquelyn , Fedrigo Olivier , Fogg John , Kirilenko Bogdan , Munegowda Chetan , Hiller Michael , Jain Aashish , Kihara Daisuke , Rhie Arang , Phillippy Adam M. , Swanson Scott A. , Jiang Peng , Clegg Dennis O. , Jarvis Erich D. , Thomson James A. , Stewart Ron , Chaisson Mark J. P. , Bukhman Yury V. 
Published: November 2022

AbstractBackgroundThe Nile rat (Avicanthis niloticus) is an important animal model because of its robust diurnal rhythm, a cone-rich retina, and a propensity to develop diet-induced diabetes without chemical or genetic modifications. A closer similarity to humans in these aspects, compared to the widely usedMus musculusandRattus norvegicusmodels, holds the promise of better translation of research findings to the clinic.ResultsWe report a 2.5 Gb, chromosome-level reference genome assembly with fully resolved parental haplotypes, generated with the Vertebrate Genomes Project (VGP). The assembly is highly contiguous, with contig N50 of 11.1 Mb, scaffold N50 of 83 Mb, and 95.2% of the sequence assigned to chromosomes. We used a novel workflow to identify 3613 segmental duplications and quantify duplicated genes. Comparative analyses revealed unique genomic features of the Nile rat, including some that affect genes associated with type 2 diabetes and metabolic dysfunctions. We discuss 14 genes that are heterozygous in the Nile rat or highly diverged from the house mouse.ConclusionsOur findings reflect the exceptional level of genomic resolution present in this assembly, which will greatly expand the potential of the Nile rat as a model organism.
Attractive and repulsive effects of sensory history concurrently shape visual perception
Authors: Moon Jongmin , Kwon Oh-Sang 
Published: November 2022

Abstract
Background
Sequential effects of environmental stimuli are ubiquitous in most behavioral tasks involving magnitude estimation, memory, decision making, and emotion. The human visual system exploits continuity in the visual environment, which induces two contrasting perceptual phenomena shaping visual perception. Previous work reported that perceptual estimation of a stimulus may be influenced either by attractive serial dependencies or repulsive aftereffects, with a number of experimental variables suggested as factors determining the direction and magnitude of sequential effects. Recent studies have theorized that these two effects concurrently arise in perceptual processing, but empirical evidence that directly supports this hypothesis is lacking, and it remains unclear whether and how attractive and repulsive sequential effects interact in a trial. Here we show that the two effects concurrently modulate estimation behavior in a typical sequence of perceptual tasks.

Results
We first demonstrate that observers’ estimation error as a function of both the previous stimulus and response cannot be fully described by either attractive or repulsive bias but is instead well captured by a summation of repulsion from the previous stimulus and attraction toward the previous response. We then reveal that the repulsive bias is centered on the observer’s sensory encoding of the previous stimulus, which is again repelled away from its own preceding trial, whereas the attractive bias is centered precisely on the previous response, which is the observer’s best prediction about the incoming stimuli.

Conclusions
Our findings provide strong evidence that sensory encoding is shaped by dynamic tuning of the system to the past stimuli, inducing repulsive aftereffects, and followed by inference incorporating the prediction from the past estimation, leading to attractive serial dependence.
Vicarious trauma on the hemodialysis healthcare workers in the besieged Ethiopia’s Tigray region: a call to action
Authors: Berhe Ephrem , Tesfay Bisrat , Teka Hale 
Published: November 2022

Abstract
Background
The war on Ethiopia’s Tigray broke out on November 4, 2020. Amid the armed conflict, governmental institutions were destroyed, people were displaced, and thousands of civilians were killed. The region was experiencing an on-and-off type of blockade since the war broke out until June 28, 2021, at which time the federal government of Ethiopia imposed a siege cutting off the region from the rest of the world. Due to the shortage of medicines and medical supplies, witnessing deaths that otherwise were preventable under normal conditions has become the daily predicament of healthcare workers. The burden of healthcare disintegration is particularly carried by patients with chronic medical illnesses including patients on dialysis.

Main body
Ayder hospital, Tigray’s flagship healthcare institution, hosts the only hemodialysis center in the entire region. This center is currently unable to give appropriate care to kidney failure patients for a lack of access to dialysis supplies and consumables due to the ongoing war and siege. This has resulted in vicarious trauma manifested with compassion fatigue, irritability, a feeling of bystander guilt; sadness about the patient’s victimization, and hopelessness among healthcare workers caring for dialysis patients.

Conclusion
The suffering of veteran patients and witnessing preventable deaths have continued to haunt and torment healthcare workers in the dialysis unit leading to vicarious trauma. Cognizant of the fact that vicarious trauma has serious health ramifications on healthcare workers; we call up the international community to advocate for a full resumption of access to healthcare and the provision of mental health support and educate and train healthcare workers dealing with end-stage kidney disease patients on hemodialysis.
Lower transmissibility of SARS-CoV-2 among asymptomatic cases: evidence from contact tracing data in Oslo, Norway
Authors: Methi Fredrik , Madslien Elisabeth Henie 
Published: November 2022

Abstract
Background
Asymptomatic COVID-19 cases have complicated the surveillance and tracking of the pandemic. Previous studies have estimated that 15–25% of all infectees remain asymptomatic.

Methods
Based on contact tracing data from Oslo, Norway, we estimated transmission and susceptibility dynamics among symptomatic and asymptomatic cases and their contacts as identified by manual contact tracing between September 1, 2020, and September 1, 2021.

Results
Among 27,473 indexes and 164,153 registered contacts, the secondary attack rate (SAR-14) was estimated to be 28% lower through asymptomatic exposure (13%) compared to symptomatic exposure (18%). Furthermore, those infected by asymptomatic cases were almost three times more likely to be asymptomatic compared to those infected by symptomatic cases.

Conclusions
Symptomatic cases spread the virus to a greater extent than asymptomatic, and infectees are more likely to be asymptomatic if their assumed infector was asymptomatic.
Glucosamine delays the progression of osteoporosis in senile mice by promoting osteoblast autophagy
Authors: Su Wei , Lv Chen , Huang Lingtuo , Zheng XiaoHang , Yang Shengwu 
Published: November 2022

AbstractBackgroundSenile osteoporosis (SOP) is one of the most prevalent diseases that afflict the elderly population, which characterized by decreased osteogenic ability. Glucosamine (GlcN) is an over-the-counter dietary supplement. Our previous study reported that GlcN promotes osteoblast proliferation by activating autophagy in vitro. The purpose of this study is to determine the effects and mechanisms of GlcN on senile osteoporosis and osteogenic differentiation in vivo.MethodsAging was induced by subcutaneous injection ofd-Galactose (d-Gal), and treated with GlcN or vehicle. The anti-senile-osteoporosis effect of GlcN was explored by examining changes in micro-CT, serum indicators, body weight, protein and gene expression of aging and apoptosis. Additionally, the effects of GlcN on protein and gene expression of osteogenesis and autophagy were observed by inhibiting autophagy with 3-methyladenine (3-MA).ResultsGlcN significantly improved bone mineral density (BMD) and bone micro-architecture, decreased skeletal senescence and apoptosis and increased osteogenesis ind-Gal induced osteoporotic mice. While all effect was reversed with 3-MA.ConclusionGlcN effectively delayed the progression of osteoporosis in senile osteoporotic mice by promoting osteoblast autophagy. This study suggested that GlcN may be a prospective candidate drug for the treatment of SOP.
Traditional Chinese medicine injections: where we are after 80-year development
Authors: Zheng Wenwen , Wu Yiyang , Gao Hanlu , Ouyang Defang 
Published: November 2022

AbstractTraditional Chinese medicine (TCM) injection is the combination of modern pharmaceutical technology and traditional Chinese prescription, which was born in 1941 and played a great role in the backward medical conditions at that time. However, the debate over TCM injections has never stopped due to adverse drug reactions (ADRs). The regulation on TCM injections has been further strengthened since 2017, which has prompted many TCM injections to carry out re-evaluations on quality, safety, efficiency as well as pharmacoeconomics, which made significant changes and progress. This review presented an up-to-date analysis of the types, amounts, and ADRs of TCM injections based on the published data and literature. This review also summarized the potential reasons for the ADRs and re-evaluation strategies. This review will provide some useful clues for TCM injections and their clinical use.
Intensified tuberculosis treatment to reduce the mortality of HIV-infected and uninfected patients with tuberculosis meningitis (INTENSE-TBM): study protocol for a phase III randomized controlled trial
Authors: Maitre Thomas , Bonnet Maryline , Calmy Alexandra , Raberahona Mihaja , Rakotoarivelo Rivonirina Andry , Rakotosamimanana Niaina , Ambrosioni Juan , Miró José M. , Debeaudrap Pierre , Muzoora Conrad , Davis Angharad , Meintjes Graeme , Wasserman Sean , Wilkinson Robert , Eholié Serge , Nogbou Frédéric Ello , Calvo-Cortes Maria-Camilla , Chazallon Corine , Machault Vanessa , Anglaret Xavier , Bonnet Fabrice 
Published: November 2022

Abstract
Background
Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis (TB), particularly in sub-Saharan Africa. Current anti-TB treatment is poorly effective since TBM mortality reaches 40% in HIV-negative patients and up to 70% in HIV-co-infected patients. To reduce TBM-induced morbidity and mortality, the INTENSE-TBM trial evaluates two interventions in both HIV-infected and uninfected patients: an anti-TB treatment intensification using oral high-dose rifampicin (35 mg/kg daily) and linezolid (1200 mg daily and then 600 mg daily) during the first 8 weeks of the anti-TB treatment and the use of adjunctive aspirin (200 mg daily).

Methods
This is a randomized controlled, phase III, multicenter, 2 × 2 factorial plan superiority trial. The trial has four arms, combining the two experimental treatments (intensified TBM regimen and aspirin) with the two reference treatments (WHO standard TB treatment and placebo), and is open-label for anti-TB treatment and double-blind placebo-controlled for aspirin treatment. This trial is conducted in adults or adolescents of age ≥15 years with TBM defined as “definite,” “probable,” or “possible” using Tuberculosis Meningitis International Research Consortium criteria, in four African countries: Ivory Coast, Madagascar, Uganda, and South Africa. The primary outcome is all-cause death between inclusion and week 40.

Discussion
The INTENSE-TBM trial represents a key opportunity to enhance TBM treatment with widely available existing drugs notably in high-incidence settings of both TB and HIV. The trial design is pragmatic and the results will permit early and effective applications in TBM patient care, in both HIV and TB high-incidence countries.

Trial registration
ClinicalTrials.gov NCT04145258. Registered on October 30, 2019.
Conducting a supportive oncology clinical trial during the COVID-19 pandemic: challenges and strategies
Authors: Deng Jie , Lukens John N. , Cohn Joy C. , McMenamin Erin , Murphy Barbara , Spinelli Bryan A. , Murphy Niya , Steinmetz Alicia K. , Landriau Megan A. , Lin Alexander 
Published: November 2022

AbstractThe coronavirus disease 2019 (COVID-19) pandemic resulted in severe interruptions to clinical research worldwide. This global public health crisis required investigators and researchers to rapidly develop and implement new strategies and solutions to mitigate its negative impact on the progress of clinical trials. In this paper, we describe the challenges, strategies, and lessons learned regarding the continuation of a supportive oncology clinical trial during the pandemic. We hope to provide insight into the implementation of clinical trials during a public health emergency to be better prepared for future instances.Trial registration: ClinicalTrials.gov, a service of the US National Institute of Health (NCT 03030859). Registered on 22 January 2017.
Phase II/III trial of hyperimmune anti-COVID-19 intravenous immunoglobulin (C-IVIG) therapy in severe COVID-19 patients: study protocol for a randomized controlled trial
Authors: Ali Shaukat , Shalim Elisha , Farhan Farah , Anjum Fatima , Ali Ayesha , Uddin Syed Muneeb , Shahab Faisal , Haider Mustafa , Ahmed Iqra , Ali Mir Rashid , Khan Sadaf , Rao Sadia , Guriro Kabeer , Elahi Saud , Ali Muhammad , Mushtaq Tehreem , Sayeed Muneeba Ahsan , Muhaymin Sheikh Muhammad , Luxmi Shoba , Saifullah  , Qureshi Saeed 
Published: November 2022

Abstract
Background
COVID-19 poses a global health challenge with more than 325 million cumulative cases and above 5 million cumulative deaths reported till January 17, 2022, by the World Health Organization. Several potential treatments to treat COVID-19 are under clinical trials including antivirals, steroids, immunomodulators, non-specific IVIG, monoclonal antibodies, and passive immunization through convalescent plasma.
The need to produce anti-COVID-19 IVIG therapy must be continued, alongside the current treatment modalities, considering the virus is still mutating into variants of concern. In this context, as the present study will exploit pooled diversified convalescent plasma collected from recovered COVID-19 patients, the proposed hyperimmune Anti-COVID-19 intravenous immunoglobulin (C-IVIG) therapy would be able to counter new infectious COVID-19 variants by neutralizing the virus particles. After the successful outcome of the phase I/II clinical trial of C-IVIG, the current study aims to further evaluate the safety and efficacy of single low dose C-IVIG in severe COVID-19 patients for its phase II/III clinical trial.

Methods
This is a phase II/III, adaptive, multi-center, single-blinded, randomized controlled superiority trial of SARS-CoV-2 specific polyclonal IVIG (C-IVIG). Patients fulfilling the eligibility criteria will be block-randomized using a sealed envelope system to receive either 0.15 g/Kg C-IVIG with standard of care (SOC) or standard of care alone in 2:1 ratio. The patients will be followed-up for 28 days to assess the primary and secondary outcomes.

Discussion
This is a phase II/III clinical trial evaluating safety and efficacy of hyperimmune anti-COVID-19 intravenous immunoglobulin (C-IVIG) in severe COVID-19 patients. This study will provide clinical evidence to use C-IVIG as one of the first-line therapeutic options for severe COVID-19 patients.

Trial registration
Registered at clinicaltrial.gov with NCT number NCT04891172 on May 18, 2021.
dynamAedes: a unified modelling framework for invasive Aedes mosquitoes
Authors: Da Re Daniele , Van Bortel Wim , Reuss Friederike , Müller Ruth , Boyer Sebastien , Montarsi Fabrizio , Ciocchetta Silvia , Arnoldi Daniele , Marini Giovanni , Rizzoli Annapaola , L’Ambert Gregory , Lacour Guillaume , Koenraadt Constantianus J. M. , Vanwambeke Sophie O. , Marcantonio Matteo 
Published: November 2022

AbstractMosquito species belonging to the genusAedeshave attracted the interest of scientists and public health officers because of their capacity to transmit viruses that affect humans. Some of these species were brought outside their native range by means of trade and tourism and then colonised new regions thanks to a unique combination of eco-physiological traits. Considering mosquito physiological and behavioural traits to understand and predict their population dynamics is thus a crucial step in developing strategies to mitigate the local densities of invasiveAedespopulations. Here, we synthesised the life cycle of four invasiveAedesspecies (Ae. aegypti,Ae. albopictus,Ae. japonicusandAe. koreicus) in a single multi-scale stochastic modelling framework which we coded in the R package . We designed a stage-based and time-discrete stochastic model driven by temperature, photo-period and inter-specific larval competition that can be applied to three different spatial scales: punctual, local and regional. These spatial scales consider different degrees of spatial complexity and data availability by accounting for both active and passive dispersal of mosquito species as well as for the heterogeneity of the input temperature data. Our overarching aim was to provide a flexible, open-source and user-friendly tool rooted in the most updated knowledge on the species’ biology which could be applied to the management of invasiveAedespopulations as well as to more theoretical ecological inquiries.Graphical Abstract
A parallel ADMM-based convex clustering method
Authors: Fodor Lidija , Jakovetić Dušan , Boberić Krstićev Danijela , Škrbić Srđan 
Published: November 2022

AbstractConvex clustering has received recently an increased interest as a valuable method for unsupervised learning. Unlike conventional clustering methods such as k-means, its formulation corresponds to solving a convex optimization problem and hence, alleviates initialization and local minima problems. However, while several algorithms have been proposed to solve convex clustering formulations, including those based on the alternating direction method of multipliers (ADMM), there is currently a limited body of work on developing scalableparallel and distributedalgorithms and solvers for convex clustering. In this paper, we develop a parallel, ADMM-based method, for a modified convex clustering sum-of-norms (SON) formulation for master–worker architectures, where the data to be clustered are partitioned across a number of worker nodes, and we provide its efficient, open-source implementation (available on Parallel ADMM-based convex clustering.https://github.com/lidijaf/Parallel-ADMM-based-convex-clustering. Accessed on 10 June 2022) for high-performance computing (HPC) cluster environments. Extensive numerical evaluations on real and synthetic data sets demonstrate a high degree of scalability and efficiency of the method, when compared with existing alternative solvers for convex clustering.