bluuebunny/crossref_metadata_2025_split huggingface dataset:
Null Association Between Isolated Orofacial Clefts and Sleep Duration: A Cohort Study From the Japan Environment and Children's Study
Authors: Sato Yukihiro , Yoshioka Eiji , Saijo Yasuaki , Kato Yasuhito , Nagaya Ken , Takahashi Satoru , Ito Yoshiya , Kobayashi Sumitaka , Ait Bamai Yu , Yamazaki Keiko , Itoh Sachiko , Miyashita Chihiro , Ikeda-Araki Atsuko , Kishi Reiko ,   The Japan Environment and Children’s Study (JECS) Group
Published: September 2022

Although children with orofacial clefts have an increased risk for sleep-disordered breathing, no studies have examined the association of sleep duration. Thus, this study aimed to examine associations between orofacial clefts and sleep duration at 1 month, 6 months, 1 year, and 3 years of age in Japan. A cohort study from the Japan Environment and Children's Study. This study consisted of 91 497 children, including ones with isolated cleft lip and palate (n = 69), isolated cleft lip only (n = 48), and isolated cleft palate only (n = 37), for which recruitment was undertaken during 2011 to 2014. Seep durations (hours per day) at 1 month, 6 months, 1 year, and 3 years of age, as reported by their mothers. In the control group, mean sleep durations and standard deviations at 1 month, 6 months, 1 year, and 3 years of age were 15.2 (2.5), 13.6 (1.9), 12.9 (1.6), and 11.6 (1.2) h, respectively. Compared to the control group, linear regression models reported effect sizes and 95% confidence intervals shorter than 1 h for sleep duration of each type of isolated orofacial cleft at each time point. This study suggested null associations between isolated orofacial clefts and sleep duration at 1 month, 6 months, 1 year, and 3 years of age. Children with isolated orofacial clefts had sufficient mean sleep duration.
Prognosis and Treatment of Metastatic Breast Cancer From A Real-World Scenario in China: A Retrospective Cohort Study
Authors: Xie Yuxin , Ma Ji , Xia Xueming , Zheng Hong , Gou Qiheng 
Published: September 2022

Objectives Although metastatic breast cancer (MBC) is considered incurable, a specific subset of patients exhibits prolonged survival and even achieve a “cure”. We retrospectively identified predictive prognostic factors and systemic therapy models to find this group of potentially cured patients. Methods Consecutive patients diagnosed with MBC from 1991-2016 in West China Hospital were included. Univariate and multivariate analyses were conducted to assess the association of clinical factors and systemic therapy models with overall survival (OS), breast cancer-specific survival (BCSS) and progression-free survival (PFS). Results The median OS was 63.4 months. Age, tumor size, lymph node metastasis, histologic grade, molecular subtype, site and number of metastases and metastasis-free interval (MFI) were related to the prognosis of MBC (P < .05). Patients with T1, N0-1, luminal A, bone metastasis, OMBC (oligometastatic breast cancer) or metastasis-free interval (MFI) ≥ 3 years showed the median OS more than 10 years (P < .001). Independent prognostic factors that correlated with OS and BCSS were residence, lymph node metastasis, histologic grade, molecular subtype, and site of metastasis (P < .05). The group of sequential chemo-endocrine therapy (ST) in hormone receptor (HR)-positive MBC patients showed the highest overall response rate (ORR) (P < .05). However, patients who received endocrine therapy (ET) showed the best OS, BCSS and PFS in the first two-line treatment, followed by ST and chemotherapy (CT) (P < .05). Conclusions Our study shows the predictive prognostic factors and systemic therapy models to facilitate patients likely to achieve long-term survival.
Effect of decentration and tilt on four novel extended range of vision intraocular lenses regarding far distance
Authors: Schmid Ruediger , Luedtke Holger , Borkenstein Andreas F. 
Published: September 2022

Purpose To analyze the effect of decentration and tilt on four novel non diffractive extended range of vision intraocular lenses (IOLs). Methods Acrysof Vivity, LuxSmart Crystal, RayOne EMV and Tecnis Eyhance were compared on the optical bench (power of 22 D each). Modulation transfer functions were obtained and Strehl ratio was calculated in an ISO-2 model. Apertures of 3 mm and 4.5 mm were applied. For qualitative assessment, United States Airforce (USAF) chart images were evaluated. Additional to centered IOLs, tilt of 5 degrees and decentration of 1 mm were applied. Results RayOne EMV was very robust against misalignment but had considerable deterioration of modulation transfer function (MTF) for large aperture with USAF images seriously blurred. Tilt and decentration decreased the performance of Eyhance significantly but had minor impact on the performance of Vivity and LuxSmart. For 4.5 mm aperture, MTF and Strehl ratio decreased markedly for all IOLs compared to 3 mm aperture size. The best MTF and Strehl ratio was obtained for Eyhance IOL well centered for both sizes of aperture. Conclusion Tilt and decentration had a major impact on the performance of Eyhance only, which performed best of all IOLs tested when well centered. With large aperture, performance of all IOLs significantly decreased. Manufacturer's different approaches for these novel IOLs to increase depth of focus by increasing spherical aberration lead to a different performance in respect to contrast function and sensitivity to misalignment. Our results apply to the distance vision. Near vision performance will be evaluated in a separate investigation.
Magnetic resonance imaging in the evaluation of suspected hip sepsis in children
Authors: Corin Nicole , Bennet Simon , Hill Joshua , Thomas Simon 
Published: September 2022

Background: Rapid and accurate diagnosis of musculoskeletal infection in children is critical to enable appropriate, targeted surgical interventions. Distinguishing between septic arthritis, myositis, and osteomyelitis around the hip can be difficult using clinical criteria and ultrasound scan alone. Materials and methods: We performed a retrospective 5-year observational review of selective magnetic resonance imaging scanning for hip sepsis in a pediatric tertiary referral center. Included were children with atraumatic hip pain with symptom duration <2 weeks, minimum of two positive modified Kocher’s criteria, and a hip effusion on ultrasound. All cases were followed up to discharge. We evaluated hip ultrasound and magnetic resonance imaging findings, operative procedures, microbiology results, duration of treatment, outcomes, and complications. Results: Fifty-one patients, 55% male, with a mean age 6.4 (0–16) years were included. Thirty-nine underwent magnetic resonance imaging scan for suspected septic arthritis of the hip; 24 prior to surgical washout (pre-emptive), and 15 afterwards (postoperative). In the pre-emptive group, 1/24 had septic arthritis, 7/24 had osteomyelitis, 6/24 had myositis, 5/24 had osteomyelitis and myositis, and 5/24 had no evidence of infective pathology. In the postoperative group, 3/15 had myositis, 3/15 had osteomyelitis, 3/15 had re-accumulation of the hip effusion requiring repeat washout, 3/15 had myositis and osteomyelitis, and 1/15 had septic arthritis of a contiguous joint. Conclusion: Pre-emptive magnetic resonance imaging scanning avoided unnecessary hip washout in 23 cases and enabled targeted drainage of an alternative focus in four of those. Magnetic resonance imaging scanning after hip washout indicated that four cases required further surgery to drain a different focus of infection.
A Novel Posterior Compression Score System for Outcome Prediction in Laminoplasty Treated OPLL Patients: A Propensity-Matched Analysis
Authors: Wei Leixin , Cao Peng , Xu Chen , Hu Bo , Wu Huiqiao , Tian Ye , Chen Huajiang , Shen Xiaolong , Yuan Wen 
Published: September 2022

Study Design A retrospective observational study. Objective To describe a novel outcome indication system, the posterior compression score (PCS), and investigate its clinical value in cervical ossification of the posterior longitudinal ligament (OPLL) patients treated with laminoplasty. Methods A total of 282 OPLL patients who underwent laminoplasty from January 2013 to December 2018 were reviewed. The patients were divided into high-score (HS) or low-score (LS) groups based on whether the PCS was over 8. Propensity score matching analysis with a caliper of .1 was used to attenuate the potential selection bias. Clinical measurements, including the Japanese Orthopedic Association (JOA) score, visual analog scale (VAS), neck disability index (NDI), and radiological measurements, including C2–C7 lordotic angle and range of motion (ROM), were compared between the groups. Results The mean follow-up period was 29.87 ± 9.17 months. There were no significant differences between the two groups regarding patients’ baseline demographical and clinical characteristics after propensity score matching. No significant differences were found in the operative time, blood loss, postoperative VAS score for neck and arm pain, postoperative C2–C7 lordotic angle, or postoperative ROM ( P > .05). However, the postoperative JOA score and recovery rate were significantly higher in the HS group than in the LS group, while the postoperative NDI was significantly lower in the HS group ( P < .05). Conclusion OPLL patients with higher PCS scores displayed better clinical outcomes. The novel PCS system is suggested to be a reliable scoring system for surgical outcome evaluation in patients with cervical OPLL.
Genome-wide association analyses of common infections in a large practice-based biobank
Authors: Jiang Lan , Kerchberger V. Eric , Shaffer Christian , Dickson Alyson L. , Ormseth Michelle J. , Daniel Laura L. , Leon Barbara G. Carranza , Cox Nancy J. , Chung Cecilia P. , Wei Wei-Qi , Stein C. Michael , Feng QiPing 
Published: September 2022

Abstract
Introduction
Infectious diseases are common causes of morbidity and mortality worldwide. Susceptibility to infection is highly heritable; however, little has been done to identify the genetic determinants underlying common infectious diseases. One GWAS was performed using 23andMe information about self-reported infections; we set out to confirm previous loci and identify new ones using medically diagnosed infections.

Methods
We used the electronic health record (EHR)-based biobank at Vanderbilt and diagnosis codes to identify cases of 12 infectious diseases in white patients: urinary tract infection, pneumonia, chronic sinus infections, otitis media, candidiasis, streptococcal pharyngitis, herpes zoster, herpes labialis, hepatitis B, infectious mononucleosis, tuberculosis (TB) or a positive TB test, and hepatitis C. We selected controls from patients with no diagnosis code for the candidate disease and matched by year of birth, sex, and calendar year at first and last EHR visits. We conducted GWAS using SAIGE and transcriptome-wide analysis (TWAS) using S-PrediXcan. We also conducted phenome-wide association study to understand associations between identified genetic variants and clinical phenotypes.

Results
We replicated three 23andMe loci (p ≤ 0.05): herpes zoster and rs7047299-A (p = 2.6 × 10–3) and rs2808290-C (p = 9.6 × 10–3;); otitis media and rs114947103-C (p = 0.04). We also identified 2 novel regions (p ≤ 5 × 10–8): rs113235453-G for otitis media (p = 3.04 × 10–8), and rs10422015-T for candidiasis (p = 3.11 × 10–8). In TWAS, four gene-disease associations were significant: SLC30A9 for otitis media (p = 8.06 × 10–7); LRP3 and WDR88 for candidiasis (p = 3.91 × 10–7 and p = 1.95 × 10–6); and AAMDC for hepatitis B (p = 1.51 × 10–6).

Conclusion
We conducted GWAS and TWAS for 12 infectious diseases and identified novel genetic contributors to the susceptibility of infectious diseases.
The effect of lockdowns and distant learning on the health-related behaviours of school students in the United Arab Emirates
Authors: Sajwani Najla Hussain , Qawas Ahmed , Al Ali Nouf , Sajwani Fatma Hussain , Alrustamani Asma Hamed , Al Maamari Shamma , Al Mazrouei Shereena K. , Al Shehhi Budoor , Al Rand Hussain , Fikri Asma Mahmoud 
Published: September 2022

Abstract
Background
The COVID-19 pandemic began to affect the world in early 2020. As a preventive measure, schools in the UAE adopted remote learning. This study aimed to assess the effects of the lockdown and remote learning on the health-related behaviours of school students in the UAE.

Methods
A cross-sectional study using an online survey comprising 33 questions related to physical activity, eating, sleeping and screen time was answered by the students’ parents. Chi-square tests, paired Student’s t tests and frequency tables were used for analysis.

Results
A total of 27,754 responses were received: 46.3% of the parents indicated a significant decrease in physical activity; 44.6% indicated an increase in unhealthy snack consumption; and 51.9% indicated decreased food ordering from restaurants. The percentage of students who slept more than 9 hours and those who slept less than 6 hours increased. Screen time increased significantly for both educational and entertainment purposes (P value < 0.0001).

Conclusion
The study showed changes in the lifestyle and health-related behaviours of school students as indicated by their parents. Risk factors such as a lack of physical activity, increased food consumption, sleeping and screen time were directly affected. Therefore, it is important to further investigate these changes and their effects to help design targeted health education programs and promotion campaigns.
Operative management of acute abdomen after bariatric surgery in the emergency setting: the OBA guidelines
Authors: De Simone Belinda , Chouillard Elie , Ramos Almino C. , Donatelli Gianfranco , Pintar Tadeja , Gupta Rahul , Renzi Federica , Mahawar Kamal , Madhok Brijesh , Maccatrozzo Stefano , Abu-Zidan Fikri M. , E. Moore Ernest , Weber Dieter G. , Coccolini Federico , Di Saverio Salomone , Kirkpatrick Andrew , Shelat Vishal G. , Amico Francesco , Pikoulis Emmanouil , Ceresoli Marco , Galante Joseph M. , Wani Imtiaz , De’ Angelis Nicola , Hecker Andreas , Sganga Gabriele , Tan Edward , Balogh Zsolt J. , Bala Miklosh , Coimbra Raul , Damaskos Dimitrios , Ansaloni Luca , Sartelli Massimo , Pararas Nikolaos , Kluger Yoram , Chahine Elias , Agnoletti Vanni , Fraga Gustavo , Biffl Walter L. , Catena Fausto 
Published: September 2022

Abstract
Background
Patients presenting with acute abdominal pain that occurs after months or years following bariatric surgery may present for assessment and management in the local emergency units. Due to the large variety of surgical bariatric techniques, emergency surgeons have to be aware of the main functional outcomes and long-term surgical complications following the most performed bariatric surgical procedures. The purpose of these evidence-based guidelines is to present a consensus position from members of the WSES in collaboration with IFSO bariatric experienced surgeons, on the management of acute abdomen after bariatric surgery focusing on long-term complications in patients who have undergone laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass.

Method
A working group of experienced general, acute care, and bariatric surgeons was created to carry out a systematic review of the literature following the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) and to answer the PICO questions formulated after the Operative management in bariatric acute abdomen survey. The literature search was limited to late/long-term complications following laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass.

Conclusions
The acute abdomen after bariatric surgery is a common cause of admission in emergency departments. Knowledge of the most common late/long-term complications (> 4 weeks after surgical procedure) following sleeve gastrectomy and Roux-en-Y gastric bypass and their anatomy leads to a focused management in the emergency setting with good outcomes and decreased morbidity and mortality rates. A close collaboration between emergency surgeons, radiologists, endoscopists, and anesthesiologists is mandatory in the management of this group of patients in the emergency setting.
Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype
Authors: Simonds Megan M. , Sullivan Kathleen E. , Brescia AnneMarie C. 
Published: September 2022

Abstract
Background
Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis; however, the mechanisms by which they contribute to disease progression are not well described. Previous studies demonstrated that rheumatoid arthritis FLS are heterogeneous, and subpopulations with transformed, aggressive phenotypes cause invasive and destructive disease activity. We employ single-cell RNA-sequencing (scRNA-seq) to investigate JIA FLS heterogeneity and gene expression that distinguishes JIA subtypes.

Methods
JIA FLS cell lines from three persistent oligoarticular, three pre-extension oligoarticular, and three polyarticular subtypes were cultured. scRNA-seq was performed by Genewiz according to 10 × Genomics Chromium protocols. SeuratR package was used for QC, analysis, and exploration of data.

Results
FLS are heterogeneous and have characteristics of fibroblasts, chondrocytes, and smooth muscle cells. The chondrocyte-like subpopulation is the predominant cell type and percentages of this subpopulation increase with disease severity. Despite overlapping subpopulations, the chondrocyte-like cells have unique genetic fingerprints that distinguish between JIA subtypes. LRRC15, GREM1, and GREM2 are overexpressed in chondrocyte-like cells from persistent oligoarticular JIA FLS compared to pre-extension oligoarticular JIA FLS. S100A4, TIMP3, and NBL1 are overexpressed in pre-extension oligoarticular JIA FLS compared to polyarticular JIA FLS. CRLF1, MFAP5, and TNXB are overexpressed in persistent oligoarticular JIA FLS compared to polyarticular JIA FLS.

Conclusions
We found biologically relevant differences in gene expression between JIA subtypes that support a critical role for FLS in pathogenesis. We also demonstrate that gene expression within the chondrocyte-like subpopulation can be used to distinguish between these subtypes.
Psychometric properties of Persian version of diabetes health literacy scale (DHLS) in patients with type 2 diabetes
Authors: Moshki Mahdi , Alami Ali , Zadehahmad Zohreh , Ghelichi-Ghojogh Mousa , Dogonchi Mitra , Jafari Alireza 
Published: September 2022

AbstractBackgroundThe purpose of this study was to investigate the psychometric properties of the Persian version of Diabetes Health Literacy Scale in type 2 diabetic patients.MethodThis cross-sectional study was conducted in 2021 in 1040 patients with type 2 diabetes in eastern Iran. Participants was selected by proportional stratified sampling method. The validity of DHLS was investigated through qualitative face validity, qualitative content validity, and structural validity (exploratory factor analysis and confirmatory factor analysis). The reliability of DHLS was checked by Cronbach's alpha coefficient, McDonald omega coefficient, and test–retest.ResultsIn exploratory factor analysis, 3 factors with eigenvalues greater than 1 were extracted, explaining 68.57% of the variance. These factors entered the confirmatory factor analysis, none of the questions were removed, and all questions had factor loading above 0.4. Cronbach's alpha coefficient and McDonald omega coefficient of DHLS were 0.919 and 0.922. Also, the Intraclass correlation coefficient of DHLS was 0.957. Finally, the DHLS was approved with 14 questions and the three subscales of Informational Health Literacy (6 items), Numerate Health Literacy (5 items), and Communicative Health Literacy (3 items).ConclusionsDHLS with 14 questions and the three subscales is a valid and reliable tool for examining diabetes health literacy in people with type 2 diabetes.
Regulatory effect of peroxiredoxin 1 (PRDX1) on doxorubicin-induced apoptosis in triple negative breast cancer cells
Authors: Han Ying-Hao , Lian Xu-Dong , Lee Seung-Jae , Li Wei-Long , Sun Hu-Nan , Jin Mei-Hua , Kwon Taeho 
Published: September 2022

AbstractPatients with triple negative breast cancer (TNBC) lack the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2; thus, conventional hormone and targeted therapies have minimal effect on them. Therefore, clinical treatment of TNBC is still based on chemotherapy and supplemented by other methods. Doxorubicin (DOX), a common drug used in TNBC chemotherapy, has high affinity for cardiolipin, and the nematosomes are rich in cardiolipin; therefore, DOX has high mitochondria-targeting ability. DOX accumulates and plunders the electrons of nicotinamide adenine dinucleotide phosphate (NADPH) and cytochrome C in mitochondria to produce semiquinone DOX. Under the action of oxygen molecules, semiquinone DOX is reduced to DOX and reactive oxygen species (ROS) are generated. The accumulation of ROS can cause mitochondrial dysfunction and lead to mitochondrial dependent apoptosis. Bioinformatic analysis of samples from TNBC patients revealed that peroxiredoxin 1 (PRDX1) was highly expressed in TNBC tissues, and the poor prognosis of patients with high PRDX1 expression was considerably increased. Previous studies determined that DOX can upregulate the expression of the PRDX1 protein in the human TNBC cell line (MDA-MB-231). Thus, we speculate that PRDX1 plays an important role in the process of DOX-induced TNBC cell apoptosis. In this study, we aimed to explore the role of PRDX1 in the process of DOX-induced TNBC cell apoptosis. We found that PRDX1 deletion increased the sensitivity of MDA-MB-231 cells to DOX, which was mainly due to mitochondrial oxidative stress caused by intracellular ROS accumulation, leading to mitochondria-dependent apoptosis. Deletion of PRDX1 promotes the PI3K/Akt signaling pathway to mediate the expression of GSK3β. Gsk3β is an upstream signal of mitochondria-dependent apoptosis, and is also an important target of ROS. PRDX1 participates in adriamycin-induced apoptosis of TNBC cells by regulating the expression level of GSK3β. Our findings present new insights to treat breast cancer and TNBC, outlines the clinical use of DOX, and provides a basic theory to develop PRDX1 gene function.