RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients
Authors:   The RA-MAP Consortium, Isaacs John D. , Brockbank Sarah , Pedersen Ayako Wakatsuki , Hilkens Catharien , Anderson Amy , Stocks Philip , Lendrem Dennis , Tarn Jessica , Smith Graham R. , Allen Ben , Casement John , Diboll Julie , Harry Rachel , Cooles Faye A. H. , Cope Andrew P. , Simpson Gemma , Toward Ruth , Noble Hayley , Parke Angela , Wu Wing , Clarke Fiona , Scott David , Scott Ian C. , Galloway James , Lempp Heidi , Ibrahim Fowzia , Schwank Samana , Molyneux Gemma , Lazarov Tomi , Geissmann Frederic , Goodyear Carl S. , McInnes Iain B. , Donnelly Iona , Gilmour Ashley , Virlan Aysin Tulunay , Porter Duncan , Ponchel Frederique , Emery Paul , El-Jawhari Jehan , Parmar Rekha , McDermott Michael F. , Fisher Benjamin A. , Young Steve P. , Jones Philip , Raza Karim , Filer Andrew , Pitzalis Costantino , Barnes Michael R. , Watson David S. , Henkin Rafael , Thorborn Georgina , Fossati-Jimack Liliane , Kelly Stephen , Humby Frances , Bombardieri Michele , Rana Sharmila , Jia Zhilong , Goldmann Katriona , Lewis Myles , Ng Sandra , Barbosa-Silva Adriano , Tzanis Evan , Gallagher-Syed Amaya , John Christopher R. , Ehrenstein Michael R. , Altobelli Gioia , Martins Sandra , Nguyen Dao , Ali Humayara , Ciurtin Coziana , Buch Maya , Symmons Deborah , Worthington Jane , Bruce Ian N. , Sergeant Jamie C. , Verstappen Suzanne M. M. , Stirling Fiona , Hughes-Morley Adwoa , Tom Brian , Farewell Vernon , Zhong Yujie , Taylor Peter C. , Buckley Christopher D. , Keidel Sarah , Cuff Carolyn , Levesque Marc , Long Andrew , Liu Zheng , Lipsky Samantha , Harvey Bohdan , Macoritto Michael , Hong Feng , Kaymakcalan Sukru , Tsuji Wayne , Sabin Tony , Ward Neil , Talbot Susan , Padhji Desmond , Sleeman Matthew , Finch Donna , Herath Athula , Lindholm Catharina , Jenkins Martin , Ho Meilien , Hollis Sally , Marshall Chris , Parker Gerry , Page Matt , Edwards Hannah , Cuza Alexandru , Gozzard Neil , Pandis Ioannis , Rowe Anthony , Capdevila Francisco Bonachela , Loza Matthew J. , Curran Mark , Verbeeck Denny , Dan Baker  , Mela Christopher M. , Vranic Ivana , Mela Catherine T. , Wright Stephen , Rowell Lucy , Vernon Emma , Joseph Nina , Payne Neil , Rao Ravi , Binks Michael , Belson Alexandra , Ludbrook Valerie , Hicks Kirsty , Tipney Hannah , Ellis Joanne , Hasan Samiul , Didierlaurent Arnaud , Burny Wivine , Haynes Andrea , Larminie Chris , Harris Ray , Dastros-Pitei Daniela , Carini Claudio , Kola Blerina , Jelinsky Scott , Hodge Martin , Maciejewski Mateusz , Ziemek Daniel , Schulz-Knappe Peter , Zucht Hans-Dieter , Budde Petra , Coles Mark , Butler James A. , Read Simon 
Published: May 2022

AbstractRheumatoid arthritis (RA) is a chronic inflammatory disorder with poorly defined aetiology characterised by synovial inflammation with variable disease severity and drug responsiveness. To investigate the peripheral blood immune cell landscape of early, drug naive RA, we performed comprehensive clinical and molecular profiling of 267 RA patients and 52 healthy vaccine recipients for up to 18 months to establish a high quality sample biobank including plasma, serum, peripheral blood cells, urine, genomic DNA, RNA from whole blood, lymphocyte and monocyte subsets. We have performed extensive multi-omic immune phenotyping, including genomic, metabolomic, proteomic, transcriptomic and autoantibody profiling. We anticipate that these detailed clinical and molecular data will serve as a fundamental resource offering insights into immune-mediated disease pathogenesis, progression and therapeutic response, ultimately contributing to the development and application of targeted therapies for RA.