bluuebunny/crossref_metadata_2025_split huggingface dataset:
A landmark-based approach to locate symptom-specific transcranial magnetic stimulation targets of depression
Authors: Du Rongrong , Zhou Qian , Hu Tianzheng , Sun Jinmei , Hua Qiang , Wang Yingru , Zhang Yuanyuan , He Kongliang , Tian Yanghua , Ji Gong-Jun , Wang Kai 
Published: September 2022

ObjectiveTwo subregions of the dorsolateral prefrontal cortex have been identified as effective repetitive transcranial magnetic stimulation (rTMS) targets for the “anxiosomatic” and “dysphoric” symptoms, respectively. We aimed to develop a convenient approach to locate these targets on the scalp.Materials and methodsIn a discovery experiment, the two personalized targets were precisely identified on 24 subjects using a neuronavigation system. Then, a localized approach was developed based on individual scalp landmarks. This “landmark-based approach” was replicated and validated in an independent cohort (N = 25). Reliability of the approach was tested by calculating the correlation of both the inter-rater and intra-rater results. Validity was tested by comparing the mean distance between the personalized and landmark-based targets to the TMS spatial resolution (i.e., 5 mm). We further conducted a total of 24 sham rTMS sessions to estimate the misplacement between the coil center and target during a 10-min stimulation without neuronavigation.ResultsThe parameters of the “landmark-based approach” in the discovery experiment were replicated well in an independent cohort. Using discovery parameters, we successfully identified the symptom-specific targets in the independent cohort. Specifically, the mean distance between the personalized and landmark-based targets on the cortex was not significantly larger than 5 mm. However, the personalized and landmark-based targets distance exceeded 5 mm in more than 50% of subjects. During the 10-min sham rTMS session, the average coil misplacement was significantly larger than 5 mm.ConclusionThe “landmark-based approach” can conveniently and reliably locate the two symptom-specific targets at group level. However, the accuracy was highly varied at individual level and further improvement is needed.
Application of the unified protocol for the transdiagnostic treatment of comorbid emotional disorders in patients with ultra-high risk of developing psychosis: A randomized trial study protocol
Authors: Peláez Trinidad , López-Carrillero Raquel , Ferrer-Quintero Marta , Ochoa Susana , Osma Jorge 
Published: September 2022

BackgroundCognitive Behavioral Therapy is delivered in most of the early intervention services for psychosis in different countries around the world. This approach has been demonstrated to be effective in decreasing or at least delaying the onset of psychosis. However, none of them directly affect the comorbidity of these types of patients that is often the main cause of distress and dysfunctionality. The Unified Protocol for the Transdiagnostic Treatment of Emotional Disorders (UP) is a psychological intervention that combines cognitive-behavioral and third-generation techniques that address emotional dysregulation as an underlying mechanism that these disorders have in common. The application of this intervention could improve the comorbid emotional symptoms of these patients.Materials and methodsThe study is a randomized controlled trial in which one group receives immediate UP plus standard intervention and the other is placed on a waiting list to receive UP 7 months later, in addition to standard care in one of our early psychosis programs. The sample will be 42 patients with UHR for psychosis with comorbid emotional symptoms. The assessment is performed at baseline, at the end of treatment, and at 3-months’ follow-up, and includes: general psychopathology, anxiety and depression, positive and negative emotions, emotional dysregulation, personality, functionality, quality of life, cognitive distortions, insight, and satisfaction with the UP intervention.DiscussionThis will be the first study of the efficacy, acceptability, and viability of the UP in a sample of young adults with UHR. The results of this study may have clinical implications, contributing to improving the model of care for young people who consult for underlying psychotic, anxiety, and/or depressive symptoms that can lead to high distress and dysfunctionality.Clinical trial registration[https://clinicaltrials.gov/], identifier [NCT04929938].
Development of an online supportive treatment module for moral injury in military veterans and police officers
Authors: ter Heide F. Jackie June , de Goede Mariëlle L. , van Dam Sanne , Ekkers Stijn 
Published: September 2022

BackgroundMilitary members and police officers often operate in high stakes situations and under high levels of physical and psychological stress. Consequently, they may be confronted with morally injurious experiences and develop moral injury. Most treatments for moral injury are cognitive-behavioral, face-to-face treatments, which may be supported by online interventions. Online interventions have shown promise in the treatment of trauma-related psychopathology, but few such interventions for moral injury yet exist.ObjectiveTo develop and conduct a preliminary evaluation of an online treatment module for moral injury in treatment-seeking military veterans and police officers, to be used in conjunction with regular face-to-face treatment.MethodAn online module was developed based on the moral injury literature, using elements from seven existing treatments. A preliminary evaluation was conducted using both quantitative and qualitative methods, and focusing on perceived feasibility, acceptability and engagement of the module, as well as potential benefits and harms. The concept module was evaluated by 15 assessors, including patient representatives, multidisciplinary caregivers and experts.ResultsThe module was rated favorably, with mean evaluation scores ranging from 7.9 to 8.8 on a 10-point scale. Several suggestions for improvement were made, especially concerning privacy issues, safety instructions, patient-therapist collaborations, and role plays, and the module was adapted accordingly.ConclusionUsing input from literature, patient representatives and experts, we developed an online treatment module for moral injury in military veterans and police officers, to be used in conjunction with face-to-face therapy. Acceptability and feasibility will be further examined in a future pilot study.
Surgical outcome predictor analysis following hand-assisted or pure laparoscopic transperitoneal nephroureterectomy using the Taiwan upper urinary tract urothelial carcinoma database
Authors: Kuo Chih-Chun , Chen Guang-Heng , Chang Chao-Hsiang , Huang Chao-Yuan , Chen Chung-Hsin , Li Ching-Chia , Wu Wen-Jeng , Yu Chih-Chin , Lo Chi-Wen , Chen Yung-Tai , Chen Shin-Hong , Cheng Pai-Yu , Hsueh Thomas Y. , Chiu Allen W. , Lin Po-Han , Tseng Jen-Shu , Lin Jen-Tai , Jiang Yuan-Hong , Wu Chia-Chang , Lin Wei-Yu , Huang Hsu-Che , Chiang Han-Sun , Chiang Bing-Juin 
Published: September 2022

PurposeTaiwan has a high incidence of upper tract urothelial carcinoma (UTUC). This study aimed to compare the surgical outcomes following transperitoneal hand-assisted laparoscopic nephroureterectomy (TP-HALNU) and transperitoneal pure laparoscopic nephroureterectomy (TP-LNU) from the Taiwan nationwide UTUC collaboration database using different parameters, including surgical volumes.Materials and methodsThe nationwide UTUC collaboration database includes 14 hospitals in Taiwan from the Taiwan Cancer Registry. We retrospectively reviewed the records of 622 patients who underwent laparoscopic nephroureterectomy between July 1988 and September 2020. In total, 322 patients who received TP-LNU or TP-HALNU were included in the final analysis. Clinical and pathological data and oncological outcomes were compared.ResultsOf the 322 patients, 181 and 141 received TP-LNU and TP-HALNU, respectively. There were no differences in clinical and histopathological data between the two groups. No differences were observed in perioperative and postoperative complications. There were no significant differences in oncological outcomes between the two surgical approaches. In the multivariate analysis, the cohort showed that age ≥70 years, positive pathological lymph node metastasis, tumors located in the upper ureter, and male sex were predictive factors associated with an increased risk of adverse oncological outcomes. A surgical volume of ≥20 cases showed a trend toward favorable outcomes on cancer-specific survival [hazard ratio (HR) 0.154, p = 0.052] and marginal benefit for overall survival (HR 0.326, p = 0.019) in the multivariate analysis.ConclusionAlthough different approaches to transperitoneal laparoscopic nephroureterectomy showed no significant differences in surgical outcomes, age, sex, lymph node metastasis, and tumor in the upper ureter in the following period were predictive factors for oncological outcomes. Higher surgical volume did not impact disease-free survival and bladder recurrence-free survival but was associated with improved overall survival and cancer-specific survival. Exploration of unknown influencing factors is warranted.
Sclerotherapy for III- and IV-degree hemorrhoids: Results of a prospective study
Authors: Lisi Giorgio , Gentileschi Paolo , Spoletini Domenico , Passaro Umberto , Orlandi Simone , Campanelli Michela 
Published: September 2022

BackgroundIn the last 2 years, anorectal surgery has been strongly affected and even surgery for urgent cases cannot be scheduled; also, patients with III- and IV-degree bleeding hemorrhoids should be treated conservatively. The aim was to evaluate the effectiveness of sclerotherapy in patients who had to postpone surgery.MethodsWe included all patients with III- and IV-degree bleeding hemorrhoids who underwent outpatient sclerotherapy. The visual analog scale and the hemorrhoid severity score were used at the baseline and at 4 weeks after the procedure with a telephone interview, and all patients were outpatient-evaluated 1 week, 1 month, and 1 year after the treatment. All pre- and postoperative data were recorded.ResultsFrom October 2020 to November 2021, 19 patients with III- (12 patients; 63%) and IV-degree (7 patients; 37%) bleeding hemorrhoids were enrolled. The mean operative time was 4.5 min, and no intraoperative complications occurred. One case of tenesmus and three failures were detected. Six months after the procedure, the overall success rate was 84%, although all of the patients enrolled reported persistent bleeding at the end of the study period. Of these, 5 patients (26%) were scheduled for surgery and 11 patients (58%) refused surgery and asked to undergo a re-do sclerotherapy.ConclusionSclerotherapy with 3% polidocanol foam is a safe and effective procedure also in III- and IV-degree bleeding hemorrhoids. The long-term data on the length of the foam remain to be evaluated in additional studies.
Visualizing and disrupting liquid films for filmwise flow condensation in horizontal minichannels
Authors: Riley Gennifer A. , Mendez Carlos Espino , Egbo Munonyedi , Hwang Gisuk , Derby Melanie M. 
Published: September 2022

This paper investigates the effects of hemispherical mounds on filmwise condensation heat transfer in micro-channels. Also investigated were the impacts that spatial orientation of the three-sided condensation surface (i.e., gravitational effects) on steam condensation, where the cooled surfaces were either the lower surface (i.e., gravity pulls liquid towards the condensing surfaces) or upper surface (i.e., gravity pulls liquid away from the condensing surfaces). Two test coupons were used with 1.9-mm hydraulic diameters and either a plain copper surface or a copper surface modified with 2-mm diameter hemispherical mounds. Heat transfer coefficients, film visualization, and pressure drop measurements were recorded for both coupons in both orientations at mass fluxes of 50 kg/m2s and 125 kg/m2s. For all test conditions, the mounds were found to increase condensation heat transfer coefficients by at minimum 13% and at maximum 79%. When the test section was inverted (i.e., condensing surface on the top of flowing steam), minimal differences were found in mound performance, while the plain coupon reduces heat transfer coefficients by as much as 14%. Flow visualization suggests that the mounds enhanced heat transfer due to the disruption of the film as well as by reducing the thermal resistance of the film. Pressure drops followed parabolic behavior with quality, being higher in the mound coupon than the plain coupon. No significant pressure drop differences in the inverted orientation were observed.
Characterization of differentially expressed and lipid metabolism-related lncRNA-mRNA interaction networks during the growth of liver tissue through rabbit models
Authors: Wang Guoze , Li Maolin , Wang Yi , Wang Binbin , Pu Hanxu , Mao Jinxin , Zhang Shuai , Zhou Shi , Luo Peng 
Published: September 2022

BackgroundCharacterization the long non-coding RNAs (lncRNAs) and their regulated mRNAs involved in lipid metabolism during liver growth and development is of great value for discovering new genomic biomarkers and therapeutic targets for fatty liver and metabolic syndrome.Materials and methodsLiver samples from sixteen rabbit models during the four growth stages (birth, weaning, sexual maturity, and somatic maturity) were used for RNA-seq and subsequent bioinformatics analyses. Differentially expressed (DE) lncRNAs and mRNAs were screened, and the cis/trans-regulation target mRNAs of DE lncRNAs were predicted. Then the function enrichment analyses of target mRNAs were performed through Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, respectively. The target protein interaction (PPI) and lncRNA-mRNA co-expression networks were constructed using string version 11.0 platform and R Stats. Finally, six lncRNAs and six mRNAs were verified taking RT-qPCR.ResultsLiver Oil Red O detection found that the liver showed time-dependent accumulation of lipid droplets. 41,095 lncRNAs, 30,744 mRNAs, and amount to 3,384 DE lncRNAs and 2980 DE mRNAs were identified from 16 cDNA sequencing libraries during the growth of liver. 689 out of all DE lncRNAs corresponded to 440 DE mRNAs by cis-regulation and all DE mRNAs could be regulated by DE lncRNAs by trans-regulation. GO enrichment analysis showed significant enrichment of 892 GO terms, such as protein binding, cytosol, extracellular exsome, nucleoplasm, and oxidation-reduction process. Besides, 52 KEGG pathways were significantly enriched, including 11 pathways of lipid metabolism were found, like Arachidonic acid metabolism, PPAR signaling pathway and Biosynthesis of unsaturated fatty acids. After the low expression DE mRNAs and lncRNAs were excluded, we further obtained the 54 mRNAs were regulated by 249 lncRNAs. 351 interaction pairs were produced among 38 mRNAs and 215 lncRNAs through the co-expression analysis. The PPI network analysis found that 10 mRNAs such as 3β-Hydroxysteroid-Δ24 Reductase (DHCR24), lathosterol 5-desaturase (SC5D), and acetyl-CoA synthetase 2 (ACSS2) were highly interconnected hub protein-coding genes. Except for MSTRG.43041.1, the expression levels of the 11 genes by RT-qPCR were the similar trends to the RNA-seq results.ConclusionThe study revealed lncRNA-mRNA interation networks that regulate lipid metabolism during liver growth, providing potential research targets for the prophylaxis and treatment of related diseases caused by liver lipid metabolism disorders.
Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression
Authors: Ponzo Matteo , Debesset Anais , Cossutta Mélissande , Chalabi-Dchar Mounira , Houppe Claire , Pilon Caroline , Nicolas-Boluda Alba , Meunier Sylvain , Raineri Fabio , Thiolat Allan , Nicolle Rémy , Maione Federica , Brundu Serena , Cojocaru Carina Florina , Bouvet Philippe , Bousquet Corinne , Gazeau Florence , Tournigand Christophe , Courty José , Giraudo Enrico , Cohen José L. , Cascone Ilaria 
Published: September 2022

Background: The pancreatic ductal adenocarcinoma (PDAC) microenvironment is highly fibrotic and hypoxic, with poor immune cell infiltration. Recently, we showed that nucleolin (NCL) inhibition normalizes tumour vessels and impairs PDAC growth. Methods: Immunocompetent mouse models of PDAC were treated by the pseudopeptide N6L, which selectively inhibits NCL. Tumour-infiltrating immune cells and changes in the tumour microenvironment were analysed. Results: N6L reduced the proportion of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) and increased tumour-infiltrated T lymphocytes (TILs) with an activated phenotype. Low-dose anti-VEGFR2 treatment normalized PDAC vessels but did not modulate the immune suppressive microenvironment. RNAseq analysis of N6L-treated PDAC tumours revealed a reduction of cancer-associated fibroblast (CAF) expansion in vivo and in vitro. Notably, N6L treatment decreased IL-6 levels both in tumour tissues and in serum. Treating mPDAC by an antibody blocking IL-6 reduced the proportion of Tregs and MDSCs and increased the amount of TILs, thus mimicking the effects of N6L. Conclusions: These results demonstrate that NCL inhibition blocks the amplification of lymphoid and myeloid immunosuppressive cells and promotes T cell activation in PDAC through a new mechanism of action dependent on the direct inhibition of the tumoral stroma.
Net-Winged Midge Genus Blepharicera Macquart (Diptera: Blephariceridae) in China: The First DNA Barcode Database with Descriptions of Four New Species and Notes on Distribution
Authors: Zhang Xiao , Yang Ding , Kang Zehui 
Published: September 2022

Mitochondrial (mt) cytochrome c oxidase 1 (COI) gene is more and more widely used for DNA barcoding, which provides a rapid and timely identification as this technique is not limited by polymorphism, sex, and life stages and fundamentally complements traditional evolutionary taxonomy. The present study generated 33 mt COI sequences of seven Chinese Blepharicera Macquart, 1843 species with an average of 594 bp, which represent the first DNA barcode database for Chinese Blepharicera. Genetic distance analysis reveals that intraspecific distances in the genus are generally less than 1.7%, and interspecific distances range from 5.4% to 20.3%. Phylogenetic analysis shows that each species recovered in our analyses is separated from all neighboring species. Based on molecular and morphological data, four Blepharicera species from China, B. beishanica sp. nov., B. dushanzica sp. nov., B. nigra sp. nov. and B. xinjiangica sp. nov., are described and illustrated as new to science. Identification keys for adults and larvae of Chinese Blepharicera are also presented. Geographical analysis shows that Southwest China is the species’ richest region. Our results will be useful in tackling taxonomic problems, understanding species distribution, and resolving nomenclature conflicts associated with Blepharicera species.
Synthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2H)-one Derivatives
Authors: Blanco Zuleima , Fernandez-Moreira Esteban , Mijares Michael R. , Celis Carmen , Martínez Gricelis , De Sanctis Juan B. , Gurská Soňa , Džubák Petr , Hajdůch Marián , Mijoba Ali , García Yael , Serrano Xenón , Herrera Nahum , Correa-Abril Jhonny , Parra Yonathan , Ángel Jorge , Ramírez Hegira , Charris Jaime E. 
Published: September 2022

The coexistence of leishmaniasis, Chagas disease, and neoplasia in endemic areas has been extensively documented. The use of common drugs in the treatment of these pathologies invites us to search for new molecules with these characteristics. In this research, we report 16 synthetic chalcone derivatives that were investigated for leishmanicidal and trypanocidal activities as well as for antiproliferative potential on eight human cancers and two nontumor cell lines. The final compounds 8–23 were obtained using the classical base-catalyzed Claisen–Schmidt condensation. The most potent compounds as parasiticidal were found to be 22 and 23, while compounds 18 and 22 showed the best antiproliferative activity and therapeutic index against CCRF-CEM, K562, A549, and U2OS cancer cell lines and non-toxic VERO, BMDM, MRC-5, and BJ cells. In the case of K562 and the corresponding drug-resistant K562-TAX cell lines, the antiproliferative activity has shown a more significant difference for compound 19 having 10.3 times higher activity against the K562-TAX than K562 cell line. Flow cytometry analysis using K562 and A549 cell lines cultured with compounds 18 and 22 confirmed the induction of apoptosis in treated cells after 24 h. Based on the structural analysis, these chalcones represent new compounds potentially useful for Leishmania, Trypanosoma cruzi, and some cancer treatments.
Thermoelectrical random stick network method and its application to carbon nanotube films
Authors: Kobayashi Junei , Yamamoto Takahiro 
Published: September 2022

Abstract
Electrical and thermal circuit analyses on a random stick network were combined to develop the simulation method to calculate the thermoelectric response of carbon nanotube (CNT) films. The experimental results were successfully reproduced with respect to the gate-voltage dependence of both the electrical conductivity and Seebeck coefficient of CNT-film field effect transistors for various mixing ratios of semiconducting/metallic CNTs. The Seebeck coefficient increases monotonically with the semiconducting CNT content and the rate of increase in the Seebeck coefficient is strongly dependent on the chemical potential (i.e. the carrier density). The thermoelectric response of aligned CNT films was also investigated. The Seebeck coefficient of an aligned CNT film was determined to be isotropic (i.e. independent of measurement in the directions parallel and perpendicular to the CNT alignment), although the electrical conductivity in the direction parallel to the CNT alignment was much larger than that in the perpendicular direction.
Peran dan Efektivitas Micronized Purified Flavonoid Fraction dalam Terapi Pengobatan Hemoroid Kelas I dan II
Authors: Stephen  , Ruchika  , Pandapotan Roy Akur , Pasaribu Donna Mesina Rosadini 
Published: September 2022

Hemoroid adalah suatu penyakit tidak menular yang terjadi di daerah anorektal. Hemoroid disebabkan oleh suatu aktivitas yang memicu pelebaran dan inflamasi pembuluh darah vena di plexus haemorrhoidalis yang terdapat di sekitar anus dan rektum. Hemoroid diklasifikasikan dalam 4 tingkatan yaitu hemoroid kelas I, II, III, dan IV. Micronized Purified Flavonoid Fraction (MPFF) adalah suatu obat plebotonik yang kerap digunakan dalam pengobatan konservatif hemoroid kelas I dan II. Tinjauan Pustaka ini bertujuan untuk memahami peran MPFF dalam terapi pengobatan hemoroid kelas I dan II serta mengevaluasi efektivitasnya dalam menangani hemoroid secara menyeluruh. Tinjauan pustaka ini ditulis dengan metode menganalisis dan meninjau secara sistematis hasil kajian dari beberapa penelitian terhadap penggunaan MPFF dalam pengobatan hemoroid. Hasil penelitian yang melibatkan 1.952 pasien hemoroid secara acak menemukan bahwa MPFF efektif dalam meredakan gejala pada 1.489 (76,3%) pasien yang menderita hemoroid. Selain itu, ditemukan juga 68 (3,5%) pasien yang mengikuti pengobatan invasif (pembedahan) untuk menangani hemoroid kelas IV dan sebanyak 395 (20,2%) pasien dengan hemoroid kelas I – III menjalani pengobatan konservatif campuran. Penelitian tersebut menunjukkan bahwa MPFF termasuk pengobatan konservatif yang cukup efektif untuk mengatasi hemoroid kelas I dan II, tetapi kurang berdampak untuk mengatasi tingkatan hemoroid yang lebih tinggi.