bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Alternative Perspective to the FMF Clinic: MCP-1 (A-2518G) and CCR2 (G190A) Polymorphisms and MCP1 Expression
Authors: ÇİTLİ Şenol , KOÇAK Nadir 
Published: October 2022

Background: Familial Mediterranean Fever (FMF) is an autoinflammatory disease and may express as various clinical findings. Chemokines are crucial elements of the inflammatory process. MCP-1 and its’ receptor CCR2 are the main chemokines for monocytes/macrophages that may play critical roles in FMF. Thus, it was aimed to investigate the MCP-1 (A-2518G) and CCR2 (G190A) polymorphisms and MCP-1 expression level, which may affect MEFV gene function.
Material and Method: Patients with FMF were identified according to the Tel-Hashomer criteria. DNA and RNA were isolated from the obtained blood samples. Genotyping analysis was performed by PCR-RFLP technique. In addition, expression analyzes were performed by Real-time PCR method. The obtained results were evaluated statistically.
Results: A total of 229 individuals (125 male and 104 female) were included in the study. While 120 individuals had FMF clinic, and 107 individuals did not have. The remaining two individuals had suspicious clinical status. In addition, while 75 individuals were homozygous mutants, 77 individuals were heterozygous mutants, and 77 individuals did not carry mutation in the MEFV gene. No significant relationship was found in between both FMF clinic and MEFV genotypes, and MCP-1 (A-2518G) and CCR2 (G190A) genotypes. In the expression analysis, MCP-1 expression increased in patients with FMF clinic compared to those without. In addition, MCP-1 expression was increased in the heterozygous MEFV group compared to those without mutation, moreover, the expression level was highest in homozygous MEFV group. In addition, according to the MCP-1 (A-2518G) genotyping, MCP-1 expression elevated in the homozygous as well as the heterozygous groups, compared to the Wild type group.
Conclusion: MCP-1 expression is increased in FMF disease, which may explain the clinical differences between FMF patients. MEFV mutations may exacerbate inflammation by increasing MCP-1 transcription. MCP-1 expression is increased in patients with MCP-1(A-2518G) mutations, which aggravates FMF clinic. MCP-1 expression may be assessed as a marker in suspicious cases.
Keywords: Familial Mediterranean Fever, MCP-1, CCR2, expression
Hepatitis A and Hepatitis E Virus Seropositivity in Patients with Hepatitis B Surface Antigen (HBsAg) Positivity
Authors: KEPENEK KURT Esma , KANDEMİR Bahar , ERAYMAN İbrahim 
Published: October 2022

Introduction: In this study, we aimed to determine the anti-HAV IgG and anti-HEV IgG seroprevalence in patients admitted to our clinic with Hepatitis B surface antigen (HBsAg) positivity.
Material and Method: Data of 1827 patients followed up on for HBsAg positivity between 2010 and 2019 were obtained retrospectively.
Results: The mean age of 1827 HBsAg positive patients was 42.71±14.84; there were 730 (39.96%) female patients and 1097 (60.04%)male. Of the 923 HBsAg positive patients whose anti-HAV IgG was measured, 830(%89,9) were detected to be positive, and 93 (10.1%) negative. Anti-HAV IgG negative patients were most often in the 21-30 age range (38.7%). Age medians were significantly different between the groups (p=0.001). HBsAg positive patients who were also positive for anti-HAV IgG tended to be older than anti-HAV IgG negative patients. In contrast, there was no significant difference in gender between anti-HAV IgG negative and positive patients (p=0.674). Of 143 HBsAg positive patients who were tested for anti-HEV-IgG, five were positive (3.5%).
Conclusion: It is of interest that we found a lower rate of anti-HAV IgG positivity in young Chronic Hepatitis B patients. When hepatitis B virus is detected, a test for anti-HAV IgG should be requested from patients and if the test result is negative, the patient should be vaccinated. Our study data analysis also revealed a low anti-HEV IgG positivity.
Definition of Intraocular Lens Position after Suture Fixation to the Iris in Remote Post-Op Period with Optical Coherence Tomography
Authors: Nikitin V. N. , Ivanov D. I. 
Published: October 2022

Introduction. Intracapsular IOL position is optimal from optical point of view and in anatomical sense results in formation of a new structure — IOL-capsular bag complex (ICBC). Stable IOL position in post-op period in some cases may be disturbed in some cases due to capsular bag fibrosis or progressive involution zonulolysis against the background of pseudoexfoliation syndrome. The disturbance of correct IOL optic part position (tilt/decentration) results in a decrease of visual acuity and appearance of optic aberrations. ICBC is a dynamic structure from architectonic point of view. Fibrosis of capsular sheets and increase of equatorial cortex (Zommering ring) may result to IOL shift in long term post-op period. Accurate definition of these parameters is crucial for estimation of impact on visual functions. The existing methods of IOL position definition are based on various principles, therefore, it is not correct to compare the parameters obtained with various devices.Pursope. To develop a method of IOL tilt and decentration definition with optical coherence tomography (Optovue, AS-OCT) and to define these parameters after suture fixation of IOL-capsular bag complex to the iris in remote post-op period.Methods. The parameters of 50 eyes operated from 2014 to 2016 for ICBC dislocation were estimated. The patients were examined again in 5 years or later. Definition of IOL position was performed with optical coherence tomography (Optovue, ASOCT) using Cornea Crossline protocol. For estimation of obtained parameters and their deviation from normal the study group was compared with a control group of 30 pseudophakic eyes with high uncorrected visual acuity.Results. In the study group the following data was obtained. Mean value of IOL tilt angle was 3.02 ± 2.04° in the horizontal meridian and 2.39 ± 1.4° in the vertical meridian. Decentration from the center of non-mydriatic pupil was 396 ± 222 microns in the horizontal meridian and 455 ± 278 microns in the vertical meridian. In the control group mean value of IOL tilt angle was 3.04° ± 1.28° in the horizontal meridian and 1.43° ± 0.53° in the vertical meridian. Decentration from the center of non-mydriatic pupil was 190 ± 114 microns in the horizontal meridian and 259 ± 108 microns in the vertical meridian. The difference between the groups is statistically significant (p < 0,05).Conclusion. The developed method allows non-contact definition of IOL position (tilt/decentration) with optical coherence tomography (Optovue, AS-OCT). The obtained data shows stable correct frontal position of IOL optic part in remote post-op period after suture fixation of ICBC to the iris.
Biomarkers of Allostatic Load in Patients with Diabetic Retinopathy
Authors: Fabrikantov O. L. , Lev I. V. , Agarkov N. M. 
Published: October 2022

Diabetic retinopathy occupies a special place among the causes of the progression of decrease and loss of visual acuity, significantly impairing the quality of life and age-related viability, an integral indicator that is considered allostatic load. However, the allostatic load in patients suffering from diabetic retinopathy, as well as in other ophthalmological diseases, has not been practically studied and biomarkers characterizing the allostatic load of patients with diabetic retinopathy remain unknown.Purpose. To study of allostatic load in patients with diabetic retinopathy and the identification of biomarkers that most determine it.Patients and methods. Allostatic load was studied in 78 elderly patients with diabetic retinopathy and in 62 patients with type 2 diabetes mellitus without diabetic retinopathy. Allostatic load was analyzed according to systolic and diastolic blood pressure, body mass index, glycated hemoglobin, total cholesterol, triglycerides, albumins, C-reactive protein, homocysteine in the blood and glomerular filtration rate.Results. The most pronounced and statistically significant excess in patients with diabetic retinopathy compared with patients with diabetes mellitus without diabetic retinopathy was found to be the content of glycated hemoglobin in the blood up to 10.2 % versus 7.4 % and homocysteine up to 15.5 mmol/l versus 7.9 mmol/l, respectively. The value of the allostatic index was significantly higher in patients with diabetic retinopathy, amounting to 4.6 ± 0.4 points, versus 2.9 ± 0.3 points in patients with diabetes mellitus without ophthalmopathology under consideration (p < 0.001). Factor analysis made it possible to identify biomarkers of allostatic load in patients with diabetic retinopathy — glycated hemoglobin, homocysteine, triglycerides and albumins.Conclusion. These biomarkers are proposed to be used in assessing the age-related viability and effectiveness of rehabilitation measures carried out among patients with diabetic retinopathy.
Spontaneous Breakaway of Tractional Flap Tear during Acute Posterior Vitreous Detachment after Laser Retinopexy
Authors: Shaimova V. A. , Trublin V. N. , Islamova G. R. , Kuchkildina S. Kh. , Shaimov T. B. , Shaimov R. B. , Kravchenko T. G. , Titova S. V. 
Published: October 2022

Flap tears in the peripheral retina are the most dangerous for the occurrence of regmatogenous retinal detachment (61–83 %), as they are always the result of dynamic vitreoretinal traction. The main method of preventing of regmatogenous retinal detachment in patients with flap tears is laser treatment. Prophylactic laser retinopexy is performed to create an area of sufficient chorioretinal adhesion completely surrounding the retinal break. Currently, the method of non-contact navigated laser retinopexy is widely used. It is safe and well-tolerated procedure equally effective to traditional laser coagulation. The reason for the progression of retinal detachment, which occurs despite preventive therapy, may be insufficient fusion around the retinal break, or the active traction force during the progression of posterior vitreous detachment (PVD). The method of flap retinotomy using modern YAG laser systems with coaxial illumination have been reported in the literature, but there are no publications on spontaneous breakaway of tractional flap tear during acute PVD progression. The case of spontaneous breakaway of tractional flap tear during acute posterior vitreous detachment after laser retinopexy is presented. A 55-year-old woman complained of floaters and photopsias in her left eye within a day. Multimodal examination was performed: visometry, perimetry, scanning laser ophthalmoscopy, ultrasound B-scanning, optical coherence tomography of the retina, fundus photoregistration. Laser treatment was performed with the Navilas Laser System 577s using the non-contact ncPRP lens.Results: The examination revealed a flap tear in the upper nasal segment with subretinal fluid around and spot hemorrhage. Preventive non-contact laser coagulation of the retina was performed in six rows together along the entire border of the tear. 11 days after the operation, the patient applied again with complaints of increased photopsias within a day. During the examination, spontaneous breakaway of the flap from the base, complete retinal attachment, absence of intraocular hemorrhage were revealed.Conclusion: Timely diagnosis and preventive laser retinopexy of peripheral retinal flap tear contributed to the prevention of development of the rhegmatogenous retinal detachment
Long-Term Results of the Treatment of Patients With Chronic Ischemia of the Lower Limbs in Combination With Ischemic Heart Disease
Authors: Alekyan B. G. , Karapetyan N. G. , Chupin A. V. , Zotikov A. E. , Varava A. B. , Knish Ju. B. , Sedgaryan M. A. 
Published: October 2022

Aim To compare long-term outcomes of x-ray endovascular (percutaneous coronary intervention, PCI, and lower limb angioplasty with stent placement, LLA; group 1) and combination treatments (PCI and open LLA surgery; group 2) in patients with chronic lower limb ischemia (CLLI) associated with ischemic heart disease (IHD).Material and methods This retrospective study has been conducted in the Vishnevsky National Medical Research Center of Surgery since 2019. The study includes 92 patients with stage 2B CLLI associated with IHD who were managed from January 1, 2017 through December 31, 2020. Long-term outcomes were evaluated in 76 (82.6 %) patients. The endpoint was severe cardiovascular complications (CVC), including death, myocardial infarction, and acute cerebrovascular disease (ACVD).Results In group 1 during the long-term period, 1 (2.7%) fatal outcome due to pneumonia was observed. In group 2, 4 (10 %) patients died: 1 (2.5 %) patient due to ACVD, 1 (2.5 %) patient due to progression of oncological process, and 2 2 (5 %) patients due to COVID-19. Also, 2 (5.5 %) and 1 (2.5 %) cases of acute coronary syndrome (ACS) were observed in groups 1 and 2, respectively (p=0.61).Conclusion In the x-ray endovascular (group1) and the combination (group 2) intervention groups, lethal outcomes due to myocardial infarction were absent. This fact confirms the importance of PCI in patients with CLLI for prevention of possible ACS in the long-term. Both therapeutic tactics in managing CLLI patients with IHD demonstrated high safety and clinical efficacy during the hospital and long-term periods and can be extensively used in routine clinical practice.
Prognostic value of non-traditional lipid parameters: Castelli Risk Index I, Castelli Risk Index II, and triglycerides to high-density lipoprotein cholesterol ratio among patients with non-ST-segment elevation myocardial infarction during 1‑year follow-up
Authors: Drwiła Dominika , Rostoff Paweł , Nessler Jadwiga , Konduracka Ewa 
Published: October 2022

Aim Concentrations of classical lipoproteines have a well-established role in non-invasive cardiology. The efficacy of the Castelli Risk Index I (CRI I), Castelli Risk Index II (CRI II), and triglycerides to high-density lipoprotein cholesterol (TG / HDL-C) ratio in clinical practice are currently under evaluation. The study aimed to assess the predictive value of CRI I, CRI II and TG / HDL-C for the incidence of Major Adverse Cardiovascular Events (MACE) and for all-cause mortality during 1‑year follow-up of patients with non-ST-segment elevation myocardial infarction (NSTEMI).Material and Methods 1,301 patients were enrolled in the study. Associations between CRI I, CRI II, TG / HDL-C and occurrence of MACE and 1‑year mortality were studied. Moreover correlations between CRI I, CRI II, and TG / HDL-C and the severity of coronary artery disease (CAD) were assessed.Results MACE occurred in 10.9 % (142) of patients, and 1‑year mortality was 13.4 % (174). None of the evaluated indices appeared to be an independent predictor of MACE in either the entire population or subpopulations, as divided according to the presence of diabetes or CAD diagnosed prior to admission. Furthermore, no dependence between 1‑year mortality and the examined indices was found. Additionally, only a weak correlation between CAD severity and CRI I was observed (R=0.08, p=0.02). No significant correlations for CRI II (p=0.07) and TG / HDL-C (p=0.6) were detected.Conclusions CRI I, CRI II and TG / HDL-C should not be used as predictors of MACE or all-cause mortality among patients with NSTEMI. Moreover, these indices do not reflect CAD severity.
Study on the morphology of nutrient foramens in humerus and its surgical implications
Authors: Ashwini N S  , Ravikiran H R  
Published: October 2022

Long bones have large or small foramina for the entry of the blood-vessels. Such foramens are known as the nutrient foramina which are large in the shafts of the largest long bones. Such foramina lead to nutrient canals through which the blood vessels enters the bone supplying the medullary cavity. The site of entry and the direction of the nutrient foramina are almost constant and are directed away from the growing ends. The nutrient artery that passes through these foramina are the main source of blood supply to humerus and is particularly important during growth period in the embryo and foetus and also during the early stage of ossification. a. To determine the direction of nutrient foramen in humerus. b. To determine the number of nutrient foramen of humerus. c. To determine the location of nutrient foramen of humerus. The study was conducted on 120 adult humeri that were obtained from the Department of Anatomy, Sri Devaraj Urs medical college, Kolar, karnataka. Bones were segregated into right and left and observed for the direction, number and location of nutrient foramens in humerus In the present study, the percentage of humerus bones with one nutrient foramen was 87% and two foramina was 9% and absent in 4%. Single nutrient foramen on right humerus bones was 92% and left side was 4% and absent in 4%. Single nutrient foramen on left humerus bones was 83% and left side was 13% and absent in 4%. 59% of the bones had nutrient foramen that were located on the medial border. Following which, the order was Anteromedial surface in (25%), Lateral border in (5%), Posterior surface in (3%) and anterior border in (3%). 81% had the nutrient foramen that was located in the middle 1/3rd, 11% at the junction between middle 1/3rd and lower 1/3rd and 3% in the lower 1/3rd of humerus. All the nutrient foramina were directed towards the elbow joint and was away from the growing end as per the law of ossification. Nutrient artery is the main source of blood supply to long bones that enters through the nutrient foramen. The surgical and anatomical knowledge of nutrient foramen in humerus or any long bone is important for orthopaedic surgeons and general surgeons during surgical procedures on the humerus such as vascular surgeries, bone grafting and transplantation.
Efficacy of four different irrigation systems on the removal of calcium hydroxide from the root canal, study: Original research
Authors: Kumar Sourya , Gupta Aditi 
Published: October 2022

: Calcium hydroxide (Ca(OH)2) has been used as a root canal medicament due to its antimicrobial activity and organic tissue dissolution capacity. To, increase the efficiency and success of root canal/endodontics treatment calcium hydroxide has to be removed from the canals walls. This study evaluate and compare four different irrigation system i.e. Conventional Irrigation (plastic 30 gauge needle), Sonic Irrigation ( Endoactivator), Ultrasonic Continuous Irrigation and Negative pressure with Endo Irrigation plus.For carrying out this study we have used 50 extracted premolar roots, preserved in sodium hypochlorite. Then they were randomly allocated five in four groups (n=10) and a control group. Specimen were statistically analysed by Kruskal Wallis test. All Testing was performed at significance level P-values 0.05. The analysis was carried out with social sciences version (SPSS)17.0 for Windows(SPSSInc.,Chicago, IL,USA). : In our present study we have found that None of the techniques used was completely able to remove Ca(OH)2 from the root canals. But the Sonic irrigation system (Endoactivator) has some potential benefit in removal of calcium hydroxide.
Perspectives on Discrimination and the European Law Combating IT
Authors: Gălăţeanu Oana Elena 
Published: October 2022

By discrimination we mean that action whereby certain persons are treated differently from others or bear the restriction of certain rights unfairly, on the basis of groundless reasons.
Direct discrimination, indirect discrimination, harassment and instigation to discrimination have been identified as forms of discrimination at social level. At the level of international society, preventing and combating any form of discrimination by resorting to the most appropriate legal measures represent a concern even today.
The right on non-discrimination prohibits those cases whereby persons or groups of persons in a similar situation are treated differently, and situations where persons or groups of persons in different situations are treated in the same way. The aim of the right on non-discrimination is to guarantee to all people equal and fair prospects of access to the opportunities granted by the society.
The discrimination’s different manifestation forms, the criteria underlying discriminatory behavior, the areas where it manifests itself and some perspectives regarding the European non-discrimination law will be presented in this study.
Reforming the Normative Frarmework of Public Function: Comparative View of Romanian and French Legislation
Authors: Patrascu Cristina 
Published: October 2022

The present article offers a brief analysis of the main juridical elements that shape the necessary framework for the organisation and coordination of public function in two administrative systems, namely Romania and France, as well as the most recent normative changes, objectives and accomplishments of public function reform in the two states. Explored mainly through qualitative methods (evaluation of specialized legislation and literature and the comparative approach), the complex topic of public function, and its newest evolutions in the countries under study, offers an interesting and rich field of research.
Similarities and differences between the two reform processes and approaches have been highlighted, together with the results attained.
Toward independence learning of disabled students through optimization of humanist approaches during the pandemic
Authors: Abu Abu Dharin , Rohmad Rohmad 
Published: October 2022

Students with disabilities have equal rights in the service of education. They need extra help in learning and developing independence. Learning in the pandemic era could not be implemented optimally. There were several obstacles when learning during the pandemic era, e.g., limited teacher–student communication, material constraints and learning methods. This condition raises the problem of developing students with disabilities’ independence in the pandemic era. This article describes and analyses how humanistic approaches can develop students with disabilities’ independent learning. This research used qualitative paradigms with phenomenological approaches. Data were collected using observation, interview and documentation techniques. Data analysis uses interactive analysis of Miles and Huberman’s models. The results showed that the humanistic approach in elementary school inclusion programmes succeeded in developing the learning independence of students with disabilities by up to 80%. Strategies for developing humanistic approaches are carried out with biological approaches by developing the curriculum independently and creating a pleasant learning atmosphere.

Keywords: Learning, independence learning, disabled students, humanist, humanistic approaches
An investigation of studies on professional ethics conducted with the participation of pre-service teachers in Turkey
Authors: Yıkmış Göksel , Akbıyık Muratcan 
Published: October 2022

The purpose of this study is to identify and analyse the studies on the professional ethics of pre-service teachers in Turkey and to present the data on pre-service teachers and their professional ethics. Accordingly, the systematic review method was used. The keyword combinations as ‘pre-service teacher and ethic’ and ‘pre-service teacher and professional ethics’ were used in both Turkish and English to conduct the literature review in the databases as Google Scholar, ERIC, PsycINFO, Web of Science and EBSCO. As a result, 18 studies from 17 scholarly journals were found using the inclusion and exclusion criteria. These studies were analysed based on the year; participants’ grades in the university, number, departments, the curricula of the departments and the contexts of the studies. It is believed that future studies should be done with the participation of pre-service teachers from the 2nd and 3rd grades. Training programmes for pre-service teachers should be organised and the effectiveness of these programmes on professional ethics can be determined.

Keywords: Ethics, pre-service teachers, professional ethics, systematic review, teachers