bluuebunny/crossref_metadata_2025_split huggingface dataset:
“We make new families:” findings from a family court mediation study
Authors: Crampton Alexandra 
Published: June 2022

AbstractMediation was brought into family court cases as a divorce litigation alternative. Today, parents are not only encouraged but mandated across most U.S. states to consider mediation before further court action can be taken. Research has not kept up with understanding how publicly mandated and subsidized mediation services become part of court cases and possible case resolution. This article reviews how mediation has evolved from outside alternative to family court “workhorse” within a family dispute resolution paradigm centered on shared parenting as in the best interest of children. Research results from a family court mediation program are presented to highlight how parents encountered and responded to mediation as an embedded part of today's family dispute resolution paradigm/court system. Especially in cases that keep coming back to court, family dispute resolution has become a means of “making family” as much as supporting family separation. Implications for practice include limitations of a mediation service as provided in an under‐resourced court and ultimate reliance upon parents to uphold the best interest standard through ongoing co‐parenting interactions.
Abnormal sensory perception masks behavioral performance of Grin1 knockdown mice
Authors: Lipina Tatiana , Men Xiaoyu , Blundell Matisse , Salahpour Ali , Ramsey Amy J. 
Published: June 2022

AbstractThe development and function of sensory systems require intact glutamatergic neurotransmission. Changes in touch sensation and vision are common symptoms in autism spectrum disorders, where altered glutamatergic neurotransmission is strongly implicated. Further, cortical visual impairment is a frequent symptom of GRIN disorder, a rare genetic neurodevelopmental disorder caused by pathogenic variants of GRIN genes that encode NMDA receptors. We asked if Grin1 knockdown mice (Grin1KD), as a model of GRIN disorder, had visual impairments resulting from NMDA receptor deficiency. We discovered that Grin1KD mice had deficient visual depth perception in the visual cliff test. Since Grin1KD mice are known to display robust changes in measures of learning, memory, and emotionality, we asked whether deficits in these higher‐level processes could be partly explained by their visual impairment. By changing the experimental conditions to improve visual signals, we observed significant improvements in the performance of Grin1KD mice in tests that measure spatial memory, executive function, and anxiety. We went further and found destabilization of the outer segment of retina together with the deficient number and size of Meissner corpuscles (mechanical sensor) in the hind paw of Grin1KD mice. Overall, our findings suggest that abnormal sensory perception can mask the expression of emotional, motivational and cognitive behavior of Grin1KD mice. This study demonstrates new methods to adapt routine behavioral paradigms to reveal the contribution of vision and other sensory modalities in cognitive performance.
Restoring vertebrate predator populations can provide landscape‐scale biological control of established invasive vertebrates: Insights from pine marten recovery in Europe
Authors: Twining Joshua P. , Lawton Colin , White Andy , Sheehy Emma , Hobson Keziah , Montgomery W. Ian , Lambin Xavier 
Published: June 2022

AbstractInvasive species pose one of the greatest global threats to biodiversity. There has been a long history of importing coevolved natural enemies to act as biological control agents to try to suppress densities of invasive species, with historically limited success and frequent adverse impacts on native biodiversity. Our understanding of the processes and drivers of successful biological control has been focussed on invertebrates and is evidently limited and potentially ill‐suited with respect to biological control of vertebrate populations. The restoration of native vertebrate predator populations provides a promising nature‐based solution for slowing, halting, or even reversing the spread of some invasive vertebrates over spatial scales relevant to the management of wildlife populations. Here, we first review the growing literature and data from the pine marten‐red and grey squirrel system in Europe. We synthesise a multi‐decadal dataset to show that the recovery of a native predator has resulted in rapid, landscape‐scale declines of an established invasive species. We then use the model system, predator–prey interaction theory, and examples from the literature to develop ecological theory relating to natural biological control in vertebrates and evolutionary processes in native‐invasive predator–prey interactions. We find support for the hypotheses that evolutionary naivety of invasive species to native predators and lack of local refuges results in higher predation of naive compared to coevolved prey. We apply lessons learnt from the marten‐squirrel model system to examine the plausibility of specific native predator solutions to some of the Earth's most devastating invasive vertebrates. Given the evidence, we conclude that depletion of vertebrate predator populations has increased ecosystem vulnerability to invasions and thus facilitated the spread of invasive species. Therefore, restoration of vertebrate predator populations is an underappreciated, fundamental, nature‐based solution to the crisis of invasive species and should be a priority for vertebrate invasive species management globally.
Both family‐based Helicobacter pylori infection control and management strategy and screen‐and‐treat strategy are cost‐effective for gastric cancer prevention
Authors: Ma Jing , Yu Miao , Shao Qiao‐Qiao , Yu Xue‐Chun , Zhang Chen , Zhao Jun‐Bo , Yuan Lin , Qi Ya‐Bin , Hu Ruo‐Bing , Wei Pei‐Ru , Xiao Wei , Chen Qi , Jia Bai‐Ling , Chen Chuan‐Liang , Lu Hong , Ding Song‐Ze 
Published: June 2022

AbstractBackgroundHelicobacter pylori (H. pylori) infection and its related diseases are substantial public health burden for highly infected areas. Recently, a novel family‐based H. pylori infection control and management (FBCM) strategy is introduced for H. pylori infection prevention and control. However, its cost‐effectiveness has not been evaluated. We conducted this health economic evaluation to investigate the cost‐effectiveness of FBCM, screen‐and‐treat, and no‐screen strategies in Chinese population.Materials and MethodsCost‐effectiveness analysis was performed using decision tree and Markov model. Parameters required for the model were from published literatures and public databases, including health state utility, screening characteristics, treatment effectiveness, and medical costs for the three strategies. Outcomes were cost, quality‐adjusted life year (QALY), incremental cost‐effectiveness ratio (ICER). Uncertainty analysis was performed to verify the robustness of this model.ResultsTo prevent gastric cancer in a cohort of 1 million asymptomatic Chinese families, FBCM and screen‐and‐treat strategies prevented 1010 and 1201 new gastric cancer cases, reduced 2809 and 3339 gastric cancer‐related death, and saved 956,971 and 1,137,549 QALYs, respectively, when compared with no‐screen strategy. Cost‐effectiveness analysis showed that FBCM strategy cost $9.18/QALY, and screen‐and‐treat strategy cost $12.08/QALY for gastric cancer prevention when compared with no‐screen strategy. One‐way sensitivity analysis revealed that screening from younger age by both strategies are more cost‐effective. When compared with FBCM strategy, screen‐and‐treat strategy saved 5.98% gastric cancer cases and 5.78% of gastric cancer deaths, but costed $9348 to reduce a gastric cancer case. Results are not sensitive to any variables, and probabilistic sensitivity analysis confirmed robustness of the results.ConclusionsBoth FBCM and screen‐and‐treat strategies are cost‐effective for gastric cancer prevention compared with no‐screen strategy. Since FBCM is more practical and convenient, it may be an efficient and excellent cost‐effective strategy for gastric cancer prevention in H. pylori and gastric cancer prevalent areas.
Scalable Bayesian Multiple Changepoint Detection via Auxiliary Uniformisation
Authors: Shaochuan Lu 
Published: June 2022

SummaryIn this paper, we perform a sparse filtering recursion for efficient changepoint detection for discrete‐time observations. We attach auxiliary event times to the chronologically ordered observations and formulate multiple changepoint problems of discrete‐time observations into continuous‐time observations. Ideally, both the computational and memory costs of the proposed auxiliary uniformisation forward‐filtering backward‐sampling algorithm can be quadratically scaled down to the number of changepoints instead of the number of observations, which would otherwise be prohibitive for a long sequence of observations. To avoid model bias, a time‐varying changepoint recurrence rate across different segments is assumed to characterise diverse scales of run lengths of the changepoints. We demonstrate the methods through simulation studies and real data analysis.
High piezoelectricity with broad temperature insensitivity in BiScO3–PbTiO3‐based piezoceramics
Authors: Dong Yazhu , Zhao Kunyu , Zhou Zhiyong , Liang Ruihong 
Published: June 2022

AbstractThe surge of interest in searching for high‐temperature piezoceramics has proved that BiScO3–PbTiO3 ceramics with high piezoelectric constant and high Curie temperature are promising for high‐temperature nondestructive inspection (NDT) applications. However, their inferior temperature stability limits the applications. In this paper, 0.365BiScO3–0.635(Pb1‐3x/2Bix)(Ti0.99Zn0.01)O3 (BS–xBPZnT) system has been investigated by doping Bi ions to A‐site and Zn ions to B‐site based on the lattice distortion and hybrid orbital theory. The transformation of domain structures has been achieved, which is varied from typical strip‐like domains to complex configuration of micro‐domain. Meanwhile, the morphotropic phase boundary (MPB) was constructed in this system. The results indicated that x = 0.01 composition can reach high piezoelectric coefficient (d33) of 490 pC/N and high Curie temperature of 428°C. Besides, the in situ high‐temperature d33 results show that x = 0.01 sample can keep stable from 50°C to 350°C, and its depolarization temperature is 410°C. The in situ high‐temperature XRD and PFM results show that the temperature stability of phase structure and domain structure is the key factor to improve the stabilization of d33. This work confirms that BS–xBPZnT ceramics have superior potential for high‐temperature application, paving a significant step toward enhancing the thermal stability of high‐temperature piezoceramics.
Using ecological networks to answer questions in global biogeography and ecology
Authors: Windsor Fredric M. , van den Hoogen Johan , Crowther Thomas W. , Evans Darren M. 
Published: June 2022

AbstractEcological networks have classically been studied at site and landscape scales, yet recent efforts have been made to collate these data into global repositories. This offers an opportunity to integrate and upscale knowledge about ecological interactions from local to global scales to gain enhanced insights from the mechanistic information provided by these data. By drawing on existing research investigating patterns in ecological interactions at continental to global scales, we show how data on ecological networks, collected at appropriate scales, can be used to generate an improved understanding of many aspects of ecology and biogeography—for example, species distribution modelling, restoration ecology and conservation. We argue that by understanding the patterns in the structure and function of ecological networks across scales, it is possible to enhance our understanding of the natural world.
Blood pressure variability and the development of hypertensive organ damage in the general population
Authors: Sugiura Tomonori , Takase Hiroyuki , Machii Masashi , Hayashi Kazusa , Nakano Suguru , Takayama Shin , Seo Yoshihiro , Dohi Yasuaki 
Published: June 2022

AbstractIncreasing blood pressure variability (BPV) has been reported to be a strong predictor of cardiovascular events in patients with hypertension. However, the effects of BPV in the general population have not been intensively studied. The present study was designed to investigate a possible relationship between year‐to‐year BPV and hypertensive target organ damage (TOD) in a relatively low‐risk general population. A total of 5489 consecutive patients (mean age 58.6 ± 10.7 years) who visited our hospital for an annual physical checkup for five consecutive years during 2008–2013 were enrolled in this study. The average systolic and diastolic blood pressures and pulse pressure were calculated, as well as standard deviation, coefficient of variation, and average real variability in blood pressures. Cross‐sectional analysis was conducted and subjects without TOD at baseline (n = 3115) were followed up (median 1827 days) with the endpoint of TOD, defined as left ventricular hypertrophy on electrocardiogram or declining glomerular filtration rate. At baseline, BPV was closely associated with TOD. During follow‐up, left ventricular hypertrophy and declining glomerular filtration rate developed in 189 and 400 subjects, respectively. Although the standard deviation for systolic blood pressure and pulse pressure predicted future development of TOD in a univariate analysis, BPV was not a significant determinant of incident TOD in adjusted Cox hazard models. These results suggest that year‐to‐year BPV is a marker of the presence of TOD in the general population but does not independently predict future TOD.
High engagement in mobile peer support is associated with better glycemic control in type 1 diabetes: A real‐world study
Authors: Liu Ziyu , Wang Chaofan , Yang Daizhi , Luo Sihui , Ding Yu , Xu Wen , Zheng Xueying , Weng Jianping , Yan Jinhua 
Published: June 2022

AbstractAims/IntroductionPeer support for diabetes has become convenient and interactive after the emergence of mobile health (mHealth). We aimed to evaluate the association between engagement in peer support through the mHealth app and glycemic control in type 1 diabetes patients.Materials and MethodsThis retrospective study included adults with type 1 diabetes who had joined the mobile community “TangTangQuan” since May 2018 for at least 1 year. “Like”, “comment” and “share” were the major interaction indicators of the mobile community and were used to assess engagement in peer support. The patients were divided into four engagement groups by quartile. The primary outcome was the change in glycosylated hemoglobin (HbA1c), mean fasting blood glucose (FBG) and postprandial blood glucose (PBG) from baseline to the 12th month. Other outcomes included the change of self‐monitoring of blood glucose frequency, hypoglycemia frequency and the proportion of reaching optimal glycemic control.ResultsAmong the 693 individuals, the HbA1c, mean FBG and PBG improved in the 12th month. Multiple regression analysis showed that higher engagement in peer support was associated with a greater reduction of HbA1c (β = −0.45, P < 0.001) and mean FBG (β = −0.82, P < 0.001). In the subgroup of poor glycemic control, the association between engagement in peer support and glycemic improvement still remained (HbA1c: β = −0.86, P = 0.002; FBG: β = −1.36, P = 0.001). The engagement in mobile peer support was positively correlated with educational level (odds ratio 1.42, P = 0.042), household income (odds ratio 1.43, P = 0.013) and the use of continuous subcutaneous insulin infusion (odds ratio 1.73, P = 0.009).ConclusionHigh engagement in mobile peer support was associated with better glycemic control in adults with type 1 diabetes.
Stigma respecified: Investigating HIV stigma as an interactional phenomenon
Authors: Hutchinson Phil 
Published: June 2022

AbstractIn this paper, I discuss stigma, understood as a category which includes acknowledged, enacted degradation, discreditation and discrimination. My discussion begins with an analysis of HIV stigma, as discussed in a social media post on Twitter. I then analyse a fictionalized clinical stigma scenario. These two analyses are undertaken to highlight aspects of the conceptual anatomy and interactional dynamics of stigma and by extension shame. Brief social media declarations and short, fictionalized clinical interactions are rich with information which helps us understand how stigma—degradation, discreditation and discrimination—is operationalized in interaction.
Differential OAT methylation correlates with cell infiltration in tumor microenvironment and overall survival postradiotherapy in oral squamous cell carcinoma patient
Authors: Sun Yu , Yang Jin , Cai He , Liu Junjiang , Liu Yangfan , Luo Jingjing , Zhou Hongmei 
Published: June 2022

AbstractBackgroundGiven that DNA methylation and tumor microenvironment (TME) are susceptible to radiotherapy, we aimed to figure out specific differential DNA methylation to reflect oral squamous cell carcinoma (OSCC) prognosis and associated effect on TME changes postradiotherapy, performing as an efficient biomarker.Materials and MethodsDifferentially methylation analysis was performed using data from The Cancer Genome Atlas. Curves of Kaplan–Meier (K‐M) survival, cumulative hazard and events, Cox proportional hazards, and linear regression model were conducted to screen and validate differential methylation genes, while multiple regression equation to analyze if ornithine aminotransferase (OAT) methylation correlates with radiotherapy. For correlation between OAT methylation and immune infiltrates, CIBERSORT and ESTIMATE algorithms were performed, following gene set enrichment analysis (GSEA) and ssGSEA analysis to evaluate biological process.ResultsCompared to normal tissues, only OAT in OSCC was differential significantly by K‐M analysis (p = 0.0364). OAT hypermethylation was associated with increased overall survival (hazard ratio: 0.65, p = 0.0358). Radiotherapy correlated with OAT methylation (β = −0.01, p = 0.0061); most patients with OAT hypermethylation were radiation‐sensitive. Hypomethylated OAT correlated with higher cell infiltrations in TME. Neuroactive ligand‐receptor interaction was most significantly related to OAT methylation (p = 9.2e−10). Sulfur metabolism was the most significantly in OAT hypermethylation group (p = 0.0041) and RIG‐I‐like receptor in OAT hypomethylation group (p = 0.0094).ConclusionOAT methylation can serve as a predictor of OSCC prognosis postradiotherapy with potential mechanism by changing cell infiltrations in TME, but further experimental study deserves to carry out confirming the role and mechanism of OAT methylation in OSCC.
Genotype–genotype interactions of the OXTR gene polymorphisms are associated with self‐reported daytime dysfunction, sleep latency and personal distress
Authors: Li Yuling , Wang Yuan , Guan Xin , Yue Jingyan , Wu Hanjing Emily , Zhen Shiqian , He Shu‐Chang , Zhang Xiang‐Yang 
Published: June 2022

SummaryThe oxytocin receptors located in the corticotropin‐releasing factor neurons of the paraventricular nucleus are stimulated by oxytocin. Oxytocin functions as the regulator of the corticotropin‐releasing factor system and in turn promotes sleep quality. The objective of this study was to examine the main and genotype–genotype interactive effects of the oxytocin receptor gene (OXTR) polymorphisms on sleep quality. A total of 324 participants were randomly recruited from a university in Beijing, China. Sleep quality was measured with the Pittsburgh Sleep Quality Index. The OXTR single‐nucleotide polymorphisms (rs2254298, rs2268498, rs13316193, rs2268490 and rs2268491) were genotyped. The results showed that gender and age were associated with various empathy traits (all p < 0.001). The Pittsburgh Sleep Quality Index was positively correlated with the Personal Distress subscale of empathy (p < 0.001). Both rs2254298 and rs2268491 interacted with rs13316193 to influence daytime dysfunction and Personal Distress (all p < 0.05), indicating that in individuals with rs13316193 CC/CT genotype, those with rs2254298 AA/AG or rs2268491 TT/TC genotypes displayed higher daytime dysfunction and Personal Distress scores than those with rs2254298 GG or rs2268491 CC genotypes. Conversely, among the individuals with rs2254298 GG or rs2268491 CC genotypes, the rs13316193 C allele carriers had lower daytime dysfunction and Personal Distress scores than rs13316193 TT homozygotes. There was also a significant interaction between rs2268490 and rs2268498 on the sleep latency dimension of the Pittsburgh Sleep Quality Index. Our findings reveal for the first time the genotype–genotype interactions of the OXTR gene on sleep quality, which may open new research avenues for studying psychopathology involving sleep problems.
Species diversity and antimicrobial resistance patterns of Enterococcus spp. isolated from mastitis cases, milking machine and the environment of dairy cows
Authors: Juliano L.C.B. , Gouvêa F.L.R. , Latosinski G.S. , Fabri F.H.H. , Salvador T.B. , Guimaraes F.F , Ribeiro M.G. , Langoni H. , Rall V.L.M. , Hernandes R.T. , Leite D.S. , Pantoja J.C.F. 
Published: June 2022

Abstract
The objectives were to study the diversity of Enterococcus spp. isolated from mastitis cases, milking equipment and the environment of dairy cows; and to determine in vitro resistance of isolates to antimicrobials that are relevant to human and animal health. Ten dairy farms were visited to collect samples from mastitis cases, faeces, bedding, aisles, water and milking equipment. Identification of Enterococcus at the species level and antimicrobial resistance testing was performed by MALDI-TOF and the disk-diffusion method, respectively. Of 365 isolates, Enterococcus hirae was the most prevalent, being more likely to be isolated from faeces than from milk (odds ratio (OR) = 39·2), liners (OR = 5·4) or bedding (OR = 2·2). Enterococcus saccharolyticus was the most prevalent in milk samples. The chances of isolating Enterococcus faecalis from milk were higher than from aisles (OR = 12·5), faeces (OR = 5·3), bedding (OR = 3·6) or liners (OR = 3·0). The odds of isolating Enterococcus faecium from faeces were higher than from liners (OR = 7·3), bedding (OR = 2·5) or aisles (OR = 2·4). Of 360 tested isolates, 1·9, 0·3 and 0·6% were resistant to penicillin, vancomycin and teicoplanin, respectively. Our results suggest that Enterococcus species can occupy specific ecological niches on dairy farms and pose a risk to public and animal health.
Exploring Boundedness for Concept‐Based Instruction of Aspect: Evidence From Learning the Spanish Preterite and Imperfect
Authors: KISSLING ELIZABETH M. , MUTHUSAMY TEJAS 
Published: June 2022

AbstractThis study investigated to what extent and how novice second‐language (L2) Spanish learners use the cognitive linguistics‐informed concept of boundedness to support their development of aspect—namely, the Spanish preterite and imperfect. The concept was presented within the framework of concept‐based instruction (CBI) as part of a regular, semester‐long U.S. college Spanish course for true beginners (N = 16). The sociocultural approach of CBI has been found to be effective for other complex L2 phenomena with more advanced learners, but the usefulness of the concept of boundedness for novice learners was untested. Definition, comprehension, verbalization, and performance data were triangulated to measure instructional effectiveness. Results suggest that the concept‐based instructional approach using the concept of boundedness supported students’ understanding of aspect, evidenced by multiple measures of conceptual development, as well as their accuracy in using aspect to create personal narratives.