bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prognostic value of arachidonic acid metabolism in breast cancer by integrated bioinformatics
Authors: Li Wenge , Guo Xiaoyu , Chen Changzheng , Li Juanjuan 
Published: August 2022

Abstract
Background
As the second cause of cancer death in women, breast cancer has become a worldwide priority. Previous studies based on tumour cell lines demonstrated that arachidonic acid (AA) and its metabolites promote cancer development. However, recent studies based on the tumour microenvironment revealed the antitumour effect of AA metabolism. Therefore, it is essential to reevaluate and elucidate the effect of AA metabolism on breast cancer.
Methods
Raw data were obtained from The Cancer Genome Atlas (TCGA), Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) and Gene Expression Omnibus (GEO) databases. The AA metabolic score of each sample, enrichment of differentially expressed genes (DEGs) and immune infiltration were analysed by bioinformatics. Cox regression and least absolute shrinkage and selection operator regression were performed to establish an AA metabolism prognostic signature. An AA metabolism-related nomogram for predicting the survival probability of patients was built.
Result
AA metabolism was related to good prognosis in the TCGA-BRCA and METABRIC cohort. DEGs enrichment suggested that the upregulated DEGs of the high AA metabolism group were significantly enriched in immune-related pathways. The high AA metabolism group was infiltrated with more CD8+ T cells and activated NK cells. An AA metabolic signature (SPINK8, KLRB1, APOD and PIGR) was constructed for breast cancer prognosis.
Conclusion
The study indicated that a high level of AA metabolism may be a biomarker for good prognosis in breast cancer, providing a possible explanation for the discouraging effect of cyclooxygenase inhibitors in cancer therapy. Moreover, a novel AA metabolic prognostic signature was constructed in the study, providing a novel strategy for breast cancer.
Synoptic and local meteorology influence on pollen concentration in a mountain valley in Central Italy: hints for localization of main sources
Authors: Pace Loretta , Incerto Angela , Curci Gabriele 
Published: August 2022

Abstract
Anemophilous pollen is one of the main causes of allergy by sensitive subjects. Due to the early and prolonged pollen season due to climate change, there is a potentially increasing risk for the European population (Lake et al., 2017). In this work, pollen and meteorological data have been associated in order to identify the favourable conditions for increasing pollen concentration. We use of the classification software from the COST733 action to classify each day of the studied period (2016-2018) among nine weather regimes. The use of a Performance Index (PI) made it possible to relate the pollen concentration to the synoptic classes and thus to associate a higher pollen concentration to a high-pressure condition. In addition, by combining wind roses and a detailed land cover thematic map, we identify the location of main potential pollen sources. The results encourage further analysis of pollen dispersal in response to climate change.
Wild type rice OsCERK1DY-mediated arbuscular mycorrhiza symbiosis boosts yield and nutrient use efficiency in rice breeding
Authors: Han Ruicai , Yang Zhou , Wang Chunquan , Zhu Shan , Tang Guoping , Shen Xianhua , Duanmu Deqiang , Cao Yangrong , Huang Renliang 
Published: August 2022

Abstract
Meeting the food demands of an ever-increasing population on the basis of resource and environmental sustainability poses major challenges to agriculture worldwide. Arbuscular mycorrhizal symbiosis (AMS) can increase the surface area of a plant’s root system, promote the absorption of phosphorus and nitrogen nutrients as well as water. Thus, it has long been theorized that rice varieties with more efficient AM symbiosis could have enhanced yield and reduced input costs, it is a new direction for the development of Green Super Rice (GSR). Our previous study identified that a variant OsCERK1DY from Dongxiang wild type rice, significanly increased the efficiency AMS in rice cultivar "ZZ35", making it an ideal gene to improve yield and nutrient use effeciency in rice breeding. In this study, we compared and examined the biomass, crop growth characteristics, yield attributes, and nutrient absorption at different soil nitrogen levels in rice cultivar "ZZ35" and its chromosome single-segment substitution line "GJDN1". The AM colonization level in GJDN1 roots was higher than that of ZZ35 in the field. Compared with ZZ35, the effective panicle number and seed-setting rate in GJDN1 were significantly higher, and the yield of GJDN1 at 75% nitrogen was 14.27% higher than the maximum yield achieved by ZZ35. When grown at the same nitrogen level, GJDN1 values were significantly higher than those of ZZ35 for the chlorophyll content, dry matter accumulation at the mature stage, population growth rate from full heading stage to mature stage, accumulation of major nutrient elements, nitrogen absorption rate from sowing stage to full heading stage, N agronomic efficiency (NAE), N recovery efficiency (NRE), and N partial factor productivity (NPFP). These results support a model in which the high level of AM symbiosis mediated by OsCERK1DY promotes the accumulation of nitrogen, phosphorus, and potassium, and improves the utilization rate of fertilizer, dry matter accumulation, and yield of rice. Thus, the OsCERK1DY gene is a strong candidate for improving yield, reducing fertilizer use, and transitioning towards greener, lower carbon agriculture.
A case report on prenatal diagnosis of Non Janiceps type of cephalopagus conjoined twins
Authors: Srin Neela , Rajgarhia Nipun , Regmi Pratik , Bajpai Amit 
Published: August 2022

Abstract
Background
Conjoined twin pregnancy is a rare occurrence resulting from the failure of a zygote to separate completely after 13 days. Cephalopagus type is the rarest type of conjoined twins. There are two types of cephalopagus twins: Janiceps (two faces are on the either side of the head) and non-janiceps (with one head and a single face). Non-janiceps type of cephalopagus are extremely rare variety of conjoined twins.
Case presentation:
A 19Y old female, primigravida, presented at 12 weeks of gestation for antenatal ultrasound. USG showed evidence of a conjoined twin with a single head with single face, fused thoraces with single heart, two lungs, fused upper abdomen with shared stomach and liver, separate pelvises with two different bladders and two pairs of upper and lower limbs. Fetal MRI corroborated these findings. The pregnancy was terminated and cephalopagus fetus was delivered vaginally. The parents were appropriately counselled for future pregnancies.
Conclusion
An extremely rare case of non-Janiceps type of cephalopagus conjoined twin gestation which was detected at 12 weeks of geatation by antenatal ultrasound and confirmed on fetal MRI. Early antenatal diagnosis is extremely important for appropriate and timely management as the prognosis is very poor in such twins. Antenatal ultrasound and fetal MRI prove very beneficial in this aspect as well as fordiagnosis of other associated fetal abnormalities.
Could the twinkling artifact be a parameter in predicting the success of SWL? A prospective study Predicting the success of SWL with the TA
Authors: SEVİM Mehmet , ALKIŞ Okan , Kartal Ibrahim Güven , Kazan Huseyin Ozgur , Sonmez Oguzhan Yusuf , Korkmaz Mehmet , ARAS Bekir 
Published: August 2022

Abstract
Introduction:
It is important to determine the factors to predict success before the treatment decision in urolithiasis. In this study, we aimed to predict the success of shock wave lithotripsy (SWL) by comparing the twinkling artifact (TA) revealed through color doppler ultrasonography (CDUS) with the stone density in non-contrast computed tomography (NCCT).
Material and method:
Eighty patients who underwent SWL between January 2021 and January 2022 were included in the study. Patients with stones of 5–20 mm in the renal pelvis and proximal ureter at NCCT were included the study. Age, gender, stone size, hydronephrosis grade, body mass index (BMI), Hounsfield unit (HU) in NCCT, and TA grades in CDUS of the patients were recorded. The stone-free rate after SWL, additional treatments, overall success rates, and the association between TA and success rates were evaluated.
Results
The mean age was 47.41 ± 15.08 years. The mean BMI was 24.49 ± 3.67 kg/m2. Twenty three (28.8%) patients were TA grade 0, 33 (41.2%) patients were grade 1, and 24 (30%) patients were grade 2. The mean HU of TA grades 0, 1, and 2 of stones were 628 ± 107, 864 ± 123, and 1166 ± 292, respectively. HU increased along with the increase in the TA grade of the stone (p < 0.01). The mean number of SWL sessions was 2.26 ± 0.75 in patients with TA grade 0, and 2.92 ± 0.40 in patients with TA grade 2. The mean number of SWL sessions increased along with the increase in TA grade (p < 0.01). Stone-free rate following SWL decreased as TA grade increased. Stone diameter and TA were the only predictors of SWL success.
Conclusion
SWL is an important treatment option in the treatment of urolithiasis. We think that TA may be useful in predicting SWL success.
Methodological review of NMA bias concepts provides groundwork for the development of a list of concepts for potential inclusion in a new risk of bias tool for network meta-analysis (RoB NMA Tool)
Authors: Lunny Carole , Veroniki Areti-Angeliki , Higgins Julian PT , Dias Sofia , Hutton Brian , Wright James M , White Ian R. , Whiting Penny , Tricco Andrea C 
Published: August 2022

Abstract

Introduction: Network meta-analyses (NMAs) have gained popularity and grown in number due to their ability to provide estimates of comparative effectiveness of multiple treatments for the same condition. The aim of this study is to conduct a methodological review to compile a preliminary list of concepts related to bias in NMAs. Methods and Analysis: We included papers that present items related to bias, reporting, or methodological quality, papers assessing the quality of NMAs, or methods papers. We searched MEDLINE, the Cochrane library, and unpublished literature. We extracted items related to bias in NMAs. An item was excluded if it was an item related to general systematic review quality or bias, and included in currently available tools such as ROBIS or AMSTAR 2. We reworded items, typically structured as questions, into concepts (i.e. general notions). Results: 181 articles were assessed at full text and 57 were included. Of these articles, 12 were tools, checklists or journal standards, 12 were guidance documents for NMAs, 26 were articles related to bias or methods, and 7 were papers that assessed the quality of NMAs. These studies yielded 99 items of which the majority related to general systematic review quality and biases and were therefore excluded. The items we included were reworded into 22 concepts specific to bias in NMAs. Conclusions: A list of 22 concepts were included. This list is not intended to be used to assess biases in NMAs, but to inform the development of items to be included in our tool.
Koncepcja egzegezy biblijnej Jana Szkota Eriugeny
Authors: Grzegorzyca Adam 
Published: August 2022

Ustanowienie w zrodzonym z Boga Ojca Synu-Logosie idealnych wzorów jest pierwotnym aktem stwórczym Boga, ujętego przez Jana Szkota Eriugenę jako Niestworzona Natura Stwarzająca, która powołuje do istnienia Stworzoną Naturę Stwarzającą. Bóg dokonał całości stworzenia jednym aktem. Stworzenie zaistniało jako proste i doskonałe według woli Boga. Eriugena uważa, że stworzenie w Logosie przyczyn prymordialnych zostało w Księdze Rodzaju opisane w formie procesu. Ten alegoryczny zapis stanowi źródło informacji o stworzonej rzeczywistości. Dla Eriugeny całe Pismo Święte jest pełnoprawnym źródłem informacji, ponieważ autorem Pisma jest zawsze prawdomówny Bóg. Stwórca pragnie, aby człowiek, który dokonał błędnego wyboru i utracił doskonałość, mógł powrócić do tego stanu, więc otwiera przed człowiekiem Księgę Natury, którą jest stworzony wszechświat oraz Księgę Pisma, którą jest Pismo Święte. Biblia, zawierająca symbole, nauki i opisy, została dana również współczesnej ludzkości, aby rozumna natura człowieka mogła nakierować go na drogę powrotu do Boga i stanu doskonałości. Analiza stworzenia oraz analiza Pisma Świętego powinny zbliżać człowieka do Boga. Wypowiedź egzegetyczna stanowi ważny aspekt interpretacji Pisma, więc Eriugena stawia warunki, które są konieczne lub stanowią wsparcie dla poprawnego wnioskowania. Warunki te dotyczą niesprzeczności pomiędzy wspomnianymi Księgami, roli ludzkiego intelektu w prowadzonych badaniach oraz znaczenia ludzkich autorytetów. Autor artykułu omawia wymagania, określone przez Eriugenę i dokonuje ich interpretacji uwzględniając fakt rozwoju różnych dziedzin współczesnej nauki.
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Zgłoszono: 29/03/2022. Zrecenzowano: 12/05/2022. Zaakceptowano do publikacji: 31/05/2022.
‘Passive-active’ As a Functional Distinction in Husserl’s Theory of Consciousness
Authors: Maciejczak Marek 
Published: August 2022

This article discusses passive and active aspects of consciousness as two equally justified roots of life experiencing the world (Weltbewusstseinsleben). The passive domain involves the synthesis of internal time, association, habituality, bodily aspects, etc. The active domain includes strictly cognitive competences of consciousness: thinking, judging, etc. What has been actively constituted becomes passive as the basic level for higher form of understanding. The two domains interweave, influence each other, complement each other, and also remain in a certain tension and discrepancy. In the broader perspective of the system of consciousness and its various layers, the passive-active differentiation must be treated functionally, and not as hierarchically arranged or constituted by separable concepts. It reflects the dynamics of the consciousness system at all its levels, and its meaning oscillates between the opposite and the overlapping.
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Received: 26/01/2022. Reviewed: 28/03/2022. Accepted: 12/05/2022.
Człowieczeństwo w ujęciu Jerzego Chmurzyńskiego
Authors: Perz Tomasz 
Published: August 2022

Człowieczeństwo to pojęcie, które oznacza cechy wspólne dla wszystkich ludzi, w tym ogół takich, które stanowią o różnicy gatunkowej pomiędzy człowiekiem a zwierzętami. Problem ten podejmował Jerzy Chmurzyński, entomolog, etolog i filozof, „ojciec polskiej etologii”, zadając pytanie: ile człowieka jest w zwierzęciu? Perspektywa badawcza etologii, przyjmując paradygmat ewolucyjny, obejmuje wszelkie organizmy żywe, zdolne do zachowania się. Artykuł przedstawia etologiczne ujęcie natury ludzkiej przez Chmurzyńskiego i formułowane na tej podstawie wnioski antropologiczne, etyczne i estetyczne. To ujęcie ukazuje z jednej strony zakorzenienie człowieka w świecie przyrody, a z drugiej takie cechy jego natury, nabyte w procesie ewolucji, które sprawiają, że człowiek przerasta poziom biologiczny. Wśród tych cech można wyróżnić: myślenie abstrakcyjne, język, etykę, estetykę i kulturę. Jerzy Chmurzyński, ukazując biologiczne korzenie człowieczeństwa, pomaga lepiej zrozumieć, co to znaczy: „być sobą w swojej ludzkiej naturze”. Wnioski w ten sposób formułowane stanowią formę „biologicznych drogowskazów”, które, mając uniwersalny charakter, mogą wzmocnić tradycyjny system etyczny, przeciwstawiając się zagrożeniu w postaci dewiacji zachowań Homo sapiens.
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Zgłoszono: 17/12/2021. Zrecenzowano: 04/02/2022. Zaakceptowano do publikacji: 11/04/2022.
Totalitaryzmy, ponowoczesność i wychowanie człowieka w świetle rozważań filozoficznych Chantal Delsol
Authors: Janas Adam 
Published: August 2022

Celem artykułu jest wykazanie związku pomiędzy ponowoczesnością i totalitaryzmami oraz wychowaniem człowieka. Przyjętym założeniem jest istnienie zróżnicowanej ontycznie rzeczywistości, której integralną częścią jest życie człowieka, pomiędzy różnymi porządkami istnienia: immanentnym (biopsychospołecznym) i transcendentnym (egzystencjalnym, metafizycznym i religijnym), w obliczu którego człowiek staje się tym, kim może i być powinien. Na podstawie analizy rozważań francuskiej myślicielki Chantal Delsol (ur. 1947) można sądzić, że wobec przesłoniętej transcendencji – zarówno w minionych totalitaryzmach, jak i współcześnie – człowiek wskutek absolutyzacji inherentnych kryteriów prawomocności tego, co immanentne, zostaje zredukowany do swoich uwarunkowań biopsychospołecznych. W konsekwencji świat staje się polem do eksperymentów społecznych, dokonywanych za pomocą terroru, bądź bardziej subtelnych środków inżynierii społecznej. Wychowanie jawi się wówczas jako ochrona człowieka przed totalitarnym potencjałem ludzkiego zbiorowego istnienia, a zatem także przed nim samym.
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Zgłoszono: 04/03/2022. Zrecenzowano: 08/04/2022. Zaakceptowano do publikacji: 12/05/2022.
Piotr Duchliński, Grzegorz Hołub (red.), "Ulepszanie poznawcze człowieka. Perspektywa filozoficzna", Wydawnictwo Naukowe Akademii Ignatianum w Krakowie, Kraków 2021, ss. 412 (rec.)
Authors: Filipek Waldemar 
Published: August 2022

Książka składa się z wprowadzenia do debaty zarówno w języku polskim jak i angielskim oraz 12 rozdziałów (referatów). Praca zawiera także noty o autorach oraz indeks. Autorami referatów są znawcy problematyki transhumanizmu, wywodzący się zarówno z renomowanych uczelni akademickich, jak i rozmaitych ośrodków badawczych. Publikacja jest nie tylko interesująca oraz inspirująca, ale też zmusza do pogłębionej refleksji nad naturą człowieka, jego istotą oraz wpływem technologii na jego życie, a także oceną etyczną tego wpływu.
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Zgłoszono: 12/12/2021. Zrecenzowano: 09/01/2022. Zaakceptowano do publikacji: 26/04/2022.
Błąd panpsychistycznego redukcjonizmu. Fundamenty nienowej ideologii. Philip Goff, "Błąd Galileusza. Fundamenty nowej nauki o świadomości", tłum. Jacek Jarocki, Wydawnictwo Naukowe PWN , Warszawa 2022, ss. 238 (rec.)
Authors: Łagosz Marek 
Published: August 2022

Książka Philipa Goffa jest pozycją z zakresu szeroko rozumianej filozofii umysłu z wątkami filozofii i metodologii nauk przyrodniczych. Łączy w sobie dość umiejętnie styl popularnonaukowy z fragmentami o charakterze bardziej systematycznej analizy naukowej oraz filozoficznej. Poza centralnym tematem rozważań, jakim jest kwestia panpsychizmu, znajdujemy w niej m.in. odniesienia do znanych w filozofii świadomości eksperymentów myślowych, jak: „jak to jest być nietoperzem?”, „pokój Marii”, „chiński pokój” czy problem „filozoficznych zombie”. Mimo licznych uwag krytycznych książkę należy uznać za względnie wartościową. Poszerza ona horyzont ontologicznych sporów o panpsychizm – m.in. w kontekście przyrodoznawstwa (fizjologia wyższej czynności nerwowej, neuronauki, mechanika kwantowa).
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Zgłoszono: 27/02/2022. Zrecenzowano: 10/03/2022. Zaakceptowano do publikacji: 11/04/2022.
Prevalence of Amiodarone Induced Hypothyroidism and Hyperthyroidism
in Patients with Heart Diseases: A Systematic Review and
Meta-Analysis
Authors: Rahimi-Bashar Farshid , Vahedian-Azimi Amir , Dalvand Sahar , Karimi Leila , Moshkani Maryam , Alimohamadi Yousef , Johnston Thomas P. , Sahebkar Amirhossein 
Published: August 2022

Background:
Due to the importance of amiodarone-induced hyperthyroidism in patients with heart failure, the purpose of the present systematic review and meta-analysis was to determine the prevalence of thyroid dysfunction (hypothyroidism and hyperthyroidism) in patients with heart disease who received amiodarone.

Methods:
Electronic databases including Scopus, PubMed, Web of science, and Science Direct were searched by two investigators. To assess the heterogeneity between the included studies, the chi-square χ2 test (α=0.05) and I2 index were used. Additionally, a random-effects model with 95% CI was used to estimate the pooled prevalence of thyroid dysfunction due to heterogeneity of the studies. To identify the cause of heterogeneity, a meta-regression analysis was employed. All analyses were performed using Stata ver13 (Stata Corporation, College Station, TX, USA).

Results:
The pooled prevalence of hypothyroidism was 23.43% (95% CI: 11.54-35.33) and hyperthyroidism was 11.61% (95% CI: 7.20-16.02). There was no significant association between the prevalence of hypothyroidism and the year of the study (P=0.152), sample size (P=0.805), and mean age of subjects in the sample groups (P=0.623). However, there was a significant association between the prevalence of hyperthyroidism and the year of the study (p=0.037), but no statistically significant association between either the prevalence of hyperthyroidism and sample size (P=0.425), or the prevalence of hyperthyroidism and the mean age of subjects in the sample groups (P=0.447).

Conclusion:
The prevalence of thyroid dysfunction in patients with cardiac arrhythmias receiving amiodarone was considerable. Extreme care should be exercised to improve monitoring of any thyroid abnormalities that may arise in patients receiving amiodarone.
RNA Hypomethylation and Unchanged DNA Methylation Levels in the
Cortex of ApoE4 Carriers and Alzheimer’s Disease Subjects
Authors: Shen Wei-Bin , Yang James Jiao , Yang Peixin 
Published: August 2022

Background:
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and ApoE4 variants are significant risk factors for AD. Epigenetic modifications are involved in AD pathology. However, it is unclear whether DNA/RNA methylation plays a role in AD pathology, and dysregulation of DNA/RNA methylation occurs in ApoE4 carriers.

Objectives:
The present study is to determine whether dysregulation of DNA/RNA methylation is present in the brains of ApoE4 carriers and AD patients.

Methods:
In this study, postmortem brain tissues from carriers of ApoE4 and ApoE3, from AD and non-AD controls were used in the analysis of DNA/RNA methylation, methyltransferases, and their demethylases.

Results:
Immunofluorescence staining indicates that RNA methylation is suppressed in ApoE4 carriers. Further analysis shows that the expression of RNA methyltransferases and an RNA methylation reader is suppressed in ApoE4 carriers, whereas RNA demethylase expression is increased. RNA hypomethylation occurs in NeuN+ neurons in ApoE4 carriers and AD patients. Furthermore, in ApoE4 carriers, both DNA methyltransferases and demethylases are downregulated, and overall DNA methylation levels are unchanged.

Conclusion:
Our finding indicates that RNA methylation decreased in ApoE4 carriers before AD pathology and AD individuals. The expression of RNA methyltransferases and RNA methylation reader is inhibited and RNA demethylase is upregulated in ApoE4 carriers, which leads to suppression of RNA methylation and the suppression precedes the AD pathogenesis and persists through AD pathology.