bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Problems In Drama 13 Reasons Why: Peirce Semiotics Approach
Authors: Jariah Ratu Ainun , Rahman Fathu , P M. Amir 
Published: September 2022

Penelitian ini berjudul Social Problems In Drama 13 Reasons Why: Peirce Semiotics Approach, dengan menganalisis 13 episode yang ditayangkan pada season pertama serial ini oleh Bryan Yorkey. Penelitian ini bertujuan untuk menganalisis masalah sosial yang terjadi pada Hanna Baker berdasarkan tanda-tanda yang muncul yang membuatnya bunuh diri dalam serial drama tersebut. Untuk mendeskripsikan masalah sosial Hanna, peneliti menggunakan metode analisis teks media Charles Sanders Peirce. Hasil penelitian ini menunjukkan bahwa setiap adegan dan dialog dalam drama menunjukkan masalah sosial yang meliputi bullying, kekerasan seksual, bunuh diri, penguntitan, dan penjurian. Hasil penelitian yang penulis dapat simpulkan bahwa permasalahan sosial yang dialami Hanna dalam serial drama “13 reason why” merupakan bentuk seni yang membujuk penonton dan menyampaikan kondisi sosial remaja yang penuh dengan perilaku menyimpang dan menyampaikan kepada semua orang untuk peduli dengan tindakan menyimpang yang ada di sekitar kita.This study is entitled Social Problems In Drama 13 Reasons Why: Peirce Semiotics Approach, by analyzing the 13 episodes that aired in the first season of this series by Bryan Yorkey. This study aims to of this research is to analyze the social problems that happened to Hanna Baker based on the signs that appeared that made her commit suicide in the drama series. To describe Hanna's social problems, the researcher uses Charles Sanders Peirce's media text analysis method. The results of this study show that every scene and dialogue in the drama shows social problems including bullying, sexual assault, suicide, stalking, and judging. The results of the study that writer can conclude that the social problems experienced by Hanna in the drama series "13 reasons why" is a form of art that persuades the audience and conveys the social conditions of teenagers who are full of deviant behavior and conveys to all people to care about deviant actions that are present around us.Keywords: Drama Series, Semiotics, 13 Reasons Why.
Percepções dos profissionais da saúde sobre o diagnóstico precoce e habilidades comunicacionais e relacionais no cuidado da criança com Transtorno do Espectro Autista
Authors: Gadbem Sofia Kirsten , Jardim Stella Pereira , Nakasu Maria Vilela Pinto , Marotti Jaqueline Brandão Guerreiro 
Published: September 2022

Objetivos: O objetivo desta pesquisa é identificar as percepções dos profissionais da saúde sobre o diagnóstico precoce e habilidades comunicacionais e relacionais no cuidado da criança com Transtorno do Espectro Autista. Metodologia: Estudo transversal, qualitativo, com profissionais da saúde, que atendem portadores doTranstorno do Espectro Autista, residentes em Itajubá-MG. Os dados foram analisados segundo a metodologia de análise de conteúdo de Bardin. Resultados: Foram encontradas seis temáticas centrais acerca das percepções dos profissionais da saúde sobre o diagnóstico precoce e habilidades comunicacionais e relacionais no cuidado da criança com Transtorno do Espectro Autista: Benefícios do diagnóstico precoce: melhor evolução clínica (100%); Relevância do acolhimento familiar no tratamento do TEA (100%); Desafios na interação profissionais de saúde paciente: estratégias de comunicação (91,6%); Competências e habilidades na relação profissional de saúde/paciente: empatia (75%); Sinais privilegiados do diagnóstico: atrasos do desenvolvimento (66,6 %); Desafios para a viabilização do tratamento junto à equipe multiprofissional (66,6 %). Conclusão: Foi possível evidenciar que o grande benefício do diagnóstico precoce do TEA é a melhor evolução clínica do paciente autista, sendo possível trabalhar estratégias que favoreçam a comunicação e o desenvolvimento integral do indivíduo.
Produção e exportação de ovos de poedeiras comerciais no Brasil
Authors: Moura Jakline Brandhuber de , Feil Marli Aguirre Aranda , Garcia Rodrigo Garófallo , Adorno Letícia Salomão Barbosa , Monteiro Caio Eduardo Oliveira , Sgavioli Sarah 
Published: September 2022

O objetivo do estudo foi avaliar a evolução da produção e exportação de ovos de poedeiras comerciais no Brasil, considerada para o período de 2007 a 2021. Foram utilizados procedimentos metodológicos que incluíram além da pesquisa bibliográfica e documental, coleta e análise de informações obtidas junto aos órgãos governamentais e imprensa responsável pelo setor. Em 2020, o Brasil foi o 5º maior produtor mundial de ovos comerciais. Em 2021, a região sudeste foi responsável pela maior produção de ovos no país. Em 2021, o consumo de ovos do brasileiro foi de 257 per capita e está abaixo quando comparado a outros países, como o México, com um consumo de 368 ovos em 2020 e os Estados Unidos da América, com um consumo de 289 ovos em 2019. Entre os anos de 2007 e 2021 houve um aumento expressivo do consumo per capita de ovos pelos brasileiros, de 49,03%. Em 2021, as exportações brasileiras para ovos in natura (69,7%) e industrializados (30,3%) obtiveram resultado inexpressivo, representando 0,46% do total produzido, mas há expectativas de melhorias para os próximos anos, com abertura de novos mercados. O Brasil demonstrou crescimento contínuo tanto na produção, quanto no consumo per capita de ovos. Há necessidade de investimento em novas tecnologias, bem como adequação às normas de sanidade e segurança alimentar, e ainda, que as agências responsáveis pela divulgação dos valores nutricionais do ovo junto à população brasileira se tornem mais eficazes e atuem no mercado de ovos industrializados, principalmente no mercado de exportação.
Derrida, Montaigne and the Time of Friendship
Authors: Rushworth Jennifer 
Published: September 2022

This chapter offers a comparison of the different approaches to writing about friendship taken by Michel de Montaigne and Jacques Derrida. Derrida takes from Montaigne’s essay ‘Of Friendship’ the Aristotelian phrase ‘O my friends, there is no friend’ and shares with Montaigne a belief in the crucial connection between friendship and mourning. Where the two authors diverge, however, is in their attitudes towards philosophy and personal experience. For Montaigne, philosophical accounts are inadequate compared with his experience of unique friendship with Étienne de la Boétie. Derrida, in contrast, in Politics of Friendship engages with philosophical accounts while avoiding discussion of his own experience of friendship. In this essay I consider the reasons for this divergence, arguing that Montaigne writes about friendship with reference to the past – both the past of philosophical tradition and the past of his friendship with La Boétie – whereas Derrida is ultimately more interested in friendship and futurity. I structure my argument around these two different times, which I frame in Derridean terms as different forms of spectres of friendship. What emerges, in the end, is Derrida’s wish to involve the reader not only as a provider of examples but even as a possible, present friend.
Sulfated carboxymethyl cellulose and carboxymethyl κ-carrageenan immobilization on 3D-printed poly-ε-caprolactone scaffolds differentially promote pre-osteoblast proliferation and osteogenic activity
Authors: Abbasi-Ravasjani Sonia , Seddiqi Hadi , Moghaddaszadeh Ali , Ghiasvand Mohammad-Ehsan , Jin Jianfeng , Oliaei Erfan , Bacabac Rommel Gaud , Klein-Nulend Jenneke 
Published: September 2022

The lack of bioactivity in three-dimensional (3D)-printing of poly-є-caprolactone (PCL) scaffolds limits cell-material interactions in bone tissue engineering. This constraint can be overcome by surface-functionalization using glycosaminoglycan-like anionic polysaccharides, e.g., carboxymethyl cellulose (CMC), a plant-based carboxymethylated, unsulfated polysaccharide, and κ-carrageenan, a seaweed-derived sulfated, non-carboxymethylated polysaccharide. The sulfation of CMC and carboxymethylation of κ-carrageenan critically improve their bioactivity. However, whether sulfated carboxymethyl cellulose (SCMC) and carboxymethyl κ-carrageenan (CM-κ-Car) affect the osteogenic differentiation potential of pre-osteoblasts on 3D-scaffolds is still unknown. Here, we aimed to assess the effects of surface-functionalization by SCMC or CM-κ-Car on the physicochemical and mechanical properties of 3D-printed PCL scaffolds, as well as the osteogenic response of pre-osteoblasts. MC3T3-E1 pre-osteoblasts were seeded on 3D-printed PCL scaffolds that were functionalized by CM-κ-Car (PCL/CM-κ-Car) or SCMC (PCL/SCMC), cultured up to 28 days. The scaffolds’ physicochemical and mechanical properties and pre-osteoblast function were assessed experimentally and by finite element (FE) modeling. We found that the surface-functionalization by SCMC and CM-κ-Car did not change the scaffold geometry and structure but decreased the elastic modulus. Furthermore, the scaffold surface roughness and hardness increased and the scaffold became more hydrophilic. The FE modeling results implied resilience up to 2% compression strain, which was below the yield stress for all scaffolds. Surface-functionalization by SCMC decreased Runx2 and Dmp1 expression, while surface-functionalization by CM-κ-Car increased Cox2 expression at day 1. Surface-functionalization by SCMC most strongly enhanced pre-osteoblast proliferation and collagen production, while CM-κ-Car most significantly increased alkaline phosphatase activity and mineralization after 28 days. In conclusion, surface-functionalization by SCMC or CM-κ-Car of 3D-printed PCL-scaffolds enhanced pre-osteoblast proliferation and osteogenic activity, likely due to increased surface roughness and hydrophilicity. Surface-functionalization by SCMC most strongly enhanced cell proliferation, while CM-κ-Car most significantly promoted osteogenic activity, suggesting that surface-functionalization by CM-κ-Car may be more promising, especially in the short-term, for in vivo bone formation.
Comparative appraisal of nutrient recovery, bio-crude, and bio-hydrogen production using Coelestrella sp. in a closed-loop biorefinery
Authors: Kopperi Harishankar , Mohan S. Venkata 
Published: September 2022

A closed loop algal-biorefinery was designed based on a three-stage integration of dairy wastewater (DWW) treatment, hydrothermal liquefaction (HTL) of defatted algal biomass, and acidogenic process in a semi-synthetic framework. Initially, Coelestrella sp SVMIICT5 was grown in a 5 L photo-bioreactor and scaled up to a 50 L flat-panel photo-bioreactor using DWW. The microalgal growth showed higher photosynthetic efficiency, resulting in a biomass growth of 3.2 g/L of DCW with 87% treatment efficiency. The biomolecular composition showed 26% lipids with a good fatty acid profile (C12-C21) as well as carbohydrate (24.9%) and protein (31.8%) content. In the second stage, the de-oiled algal biomass was valorized via HTL at various temperatures (150°C, 200°, and 250°C) and reaction atmospheres (N2 and H2). Among these, the 250°C (H2) condition showed a 52% bio-crude fraction and an HHV of ∼29.47 MJ/kg (bio-oil) with a saturated hydrocarbon content of 64.3% that could be further upgraded to jet fuels. The energy recovery (73.01%) and elemental enrichment (carbon; 65.67%) were relatively greater in H2 compared to N2 conditions. Finally, dark fermentation of the complex-structured HTL-AF stream resulted in a total bio-H2 production of 231 ml/g of TOC with a 63% treatment efficiency. Life cycle analysis (LCA) was also performed for the mid-point and damage categories to assess the sustainability of the integrated process. Thus, the results of this study demonstrated comprehensive wastewater treatment and valorization of de-oiled algal biomass for chemical/fuel intermediates in the biorefinery context by low-carbon processes.
Microfluidics combined with fluorescence in situ hybridization (FISH) for Candida spp. detection
Authors: Barbosa Violina Baranauskaite , Rodrigues Célia F. , Cerqueira Laura , Miranda João M. , Azevedo Nuno F. 
Published: September 2022

One of the most prevalent healthcare-associated infection is the urinary tract infection (UTI), caused by opportunistic pathogens such as Candida albicans or non-albicans Candida species (NACS). Urine culture methods are routinely used for UTI diagnostics due to their specificity, sensitivity and low-cost. However, these methods are also laborious, time- and reagent-consuming. Therefore, diagnostic methods relying on nucleic acids have been suggested as alternatives. Nucleic acid-based methods can provide results within 24 h and can be adapted to point-of-care (POC) detection. Here, we propose to combine fluorescence in situ hybridization (FISH) with a microfluidic platform for the detection of Candida spp. As a case study we used C. tropicalis, which is reported as the second most common NACS urine isolate obtained from patients suspected with UTI. The microfluidic platform proposed in this study relies on hydrodynamic trapping, and uses physical barriers (e.g., microposts) for the separation of target cells from the suspension. Using a specific peptide nucleic acid (PNA) probe, the FISH procedure was applied onto previously trapped C. tropicalis cells present inside the microfluidic platform. Fluorescence signal intensity of hybridized cells was captured directly under the epifluorescence microscope. Overall, the PNA probe successfully detected C. tropicalis in pure culture and artificial urine (AU) using FISH combined with the microfluidic platform. Our findings reveal that FISH using nucleic acid mimics (PNA) in combination with microfluidics is a reliable method for the detection of microorganisms such as C. tropicalis. As such, this work provides the basis for the development of a POC detection platform in the future.
Property-governed performance of platinum-modified titania photocatalysts
Authors: Wang Kunlei , Kowalska Ewa 
Published: September 2022

Titania is probably the most widely investigated semiconductor photocatalyst because of various advantages, such as high activity, thermal and chemical stability, low price, abundance, and negligible toxicity. However, pristine titania is also characterized by charge carriers’ recombination, and thus lower quantum yields of photocatalytic reactions than theoretical 100%. Moreover, its wide bandgap, despite being recommended for excellent redox properties, means also inactivity under visible part of solar radiation. Accordingly, titania has been surface modified, doped and coupled with various elements/compounds. For example, platinum deposited on the surface of titania has shown to improve both UV activity and the performance under vis. Although the studies on titania modification with platinum started almost half a century ago, and huge number of papers have been published up to now, it is unclear which properties are the most crucial and recommended to obtain highly efficient photocatalyst. In the literature, the opposite findings could be found on the property-governed activities that could result from huge differences in the reaction systems, and also examined photocatalysts. Considering the platinum properties, its content, the size of nanoparticles and the oxidation state, must be examined. Obviously, the characteristics of titania also influence the resultant properties of deposited platinum, and thus the overall photocatalytic performance. Although so many reports on Pt/TiO2 have been published, it is hardly possible to give indispensable advice on the recommended properties. However, it might be concluded that usually fine platinum NPs uniformly deposited on the titania surface result in high photocatalytic activity, and thus in the low optimal content of necessary platinum. Moreover, the aggregation of titania particles might also help in the lowering the necessary platinum amount (even to 0.2 wt%) due to the interparticle electron transfer mechanism between titania particles in one aggregate. In respect of platinum state, it is thought that it is highly substrate-specific case, and thus either positively charged or zero valent platinum is the most recommended. It might be concluded that despite huge number of papers published on platinum-modified titania, there is still a lack of comprehensive study showing the direct correlation between only one property and the resultant photocatalytic activity.
Combined Non-Invasive Prediction and New Biomarkers of Oral and Fecal Microbiota in Patients With Gastric and Colorectal Cancer
Authors: Zhang Chaoyang , Hu Asheng , Li Jingxing , Zhang Fangfang , Zhong Pei , Li Yaxian , Li Yongxiang 
Published: September 2022

BackgroundThere is no information on the commonality and specificity of oral and fecal microbiota in patients with gastric cancer (GC) and colorectal cancer (CRC).MethodsThe high-throughput 16S rRNA gene V4 region sequencing was used to perform bioinformatics analysis of oral, fecal, and tissue microbiota in GC (76 subjects), CRC (53), and healthy controls (HC, 70). Furthermore, we determined the microbial characteristics of each part, constructed and verified three classifiers for GC and CRC, and evaluated curves of receiver operating characteristic and precision–recall with probability of disease.ResultsCompared to HC, the microbial richness and diversity of GC and CRC decreased in oral cavity and increased in stool; additionally, these indexes in GC tissue were higher than those in CRC tissue. In GC and CRC patients, Haemophilus, Neisseria, Faecalibacterium, and Romboutsia were significantly reduced compared to the relative abundance value of oral or fecal bacterial genera in the HC group, while the Streptococcus, Gemella, Escherichia-Shigella, and Fusobacterium were significantly increased. The oral and tissue microbiota have similar and abundant shared bacterial networks. The single and combined microbial detection have good AUC values based on POD indices for predicting GC, CRC, and gastrointestinal (GI) cancers (GC and CRC).ConclusionThis study is the first to examine the characteristics of oral, fecal, and tumor microbiota in GC and CRC patients, and the similarities and differences in their microbial changes are reported. These oral or fecal bacteria (Haemophilus, Neisseria, Faecalibacterium, Romboutsia, Streptococcus, Gemella, Escherichia-Shigella, and Fusobacterium) may be involved in tumor evolution as potentially characteristic genera. In addition, both oral and fecal microbial detection may provide a solid theoretical foundation for the non-invasive prediction of these cancers.
Publication trends of research on sepsis and programmed cell death during 2002–2022: A 20-year bibliometric analysis
Authors: Li Jing-yan , Yao Ren-qi , Xie Min-yue , Zhou Qi-yuan , Zhao Peng-yue , Tian Ying-ping , Yao Yong-ming 
Published: September 2022

BackgroundSepsis is considered an intractable dysfunction that results from the disordered host immune response to uncontrolled infection. Even though the precise mechanism of sepsis remains unclear, scientific advances have highlighted the key role of various programmed cell death processes in the pathophysiology of sepsis. The current study aims to explore the worldwide research trend on programmed cell death in the setting of sepsis and assesses the achievements of publications from various countries, institutions, journals, and authors globally.Material and methodsAssociated publications during 2002–2022 with the topical subject of sepsis and programmed cell death were extracted from the Web of Science. VOSviewer was utilized to evaluate and map the published trend in the relevant fields.ResultsAll 2,037 relevant manuscripts with a total citation of 71,575 times were screened out by the end of 1 January 2022. China accounted for the largest number of publications (45.07%) and was accompanied by corporate citations (11,037) and H-index (48), which ranked second globally. The United States has been ranked first place with the highest citations (30,775) and H-index (88), despite a low publication number (29.95%), which was subsequent to China. The journal Shock accounted for the largest number of publications in this area. R. S. Hotchkiss, affiliated with Washington University, was considered to have published the most papers in the relevant fields (57) and achieved the highest citation frequencies (9,523). The primary keywords on the topic of programmed cell death in sepsis remarkably focused on “inflammation” “immunosuppression”, and “oxidative stress”, which were recognized as the core mechanisms of sepsis, eventually attributing to programmed cell death. The involved research on programmed cell death induced by immune dysregulation of sepsis was undoubtedly the hotspot in the pertinent areas.ConclusionsThe United States has been academically outstanding in sepsis-related research. There appears to be an incompatible performance between publications and quantity with China. Frontier advances may be consulted in the journal Shock. The leading-edge research on the scope of programmed cell death in sepsis should preferably focus on immune dissonance-related studies in the future.
Case report: Evaluation of myocardial microcirculation in patients with breast cancer after anthracycline chemotherapy by using intravoxel incoherent motion imaging
Authors: Li Shilan , Tian Di , Li Xin , Li Jia , Song Qingwei , Xia Yunlong , Li Zhiyong 
Published: September 2022

IntroductionAnthracycline chemotherapy drugs can produce cardiotoxicity in patients with breast cancer, leading to myocardial cell death and fibrosis, further developing into cardiac failure. However, the condition of myocardial microcirculation was unknown in breast cancer after anthracycline chemotherapy. As a result, intravoxel incoherent motion (IVIM) imaging was used to non-invasively observe the condition of myocardial microcirculation in a patient with breast cancer after anthracycline chemotherapy.Case reportA 43-year-old female patient with a right breast lump was reported. Preoperative ultrasound-guided needle biopsy showed invasive carcinoma of the right breast with fibroadenoma. Sentinel lymph node biopsy combined with simplified radical surgery for right breast cancer was performed. Postoperative pathological findings reported breast cancer (pT2N2M0 IIIA). The patient underwent eight sessions of the EC-TH chemotherapy scheme, and the EC and the TH schemes were adopted for the first four sessions and the last four sessions, respectively. During chemotherapy, during which there was the occurrence of Grade II myelosuppression, chest CT and abdomen CT showed no metastasis, and ECG and cardiac ultrasound reports returned to normal. Cardiac cine magnetic resonance and IVIM imaging were performed at the beginning of the first chemotherapy session (baseline) and after the third, fifth, and eighth chemotherapy sessions, respectively. We found that the fast apparent diffusion coefficient (ADCfast) and f parameters appeared to show a downward trend from the baseline to the fifth chemotherapy session, where the IVIMfast values declined from 163 × 10−3 mm2/s to 148 × 10−3 mm2/s and finally to 134 × 10−3 mm2/s and f values declined from 45% to 36% and then to 30%, respectively. ADCfast and f values showed an inclination from the fifth and eighth chemotherapy sessions.ConclusionOur case report showed that IVIM technology can likely detect non-invasive myocardial microcirculation early and quantitatively after anthracycline chemotherapy in patients with breast cancer. That is, IVIM technology seems to be helpful for cardiovascular risk monitoring and prognosis assessment of myocardial microcirculation in patients with breast cancer after anthracycline chemotherapy.