bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palmatine Attenuates Metastatic Lung Colonization of Triple Negative Breast Cancer Cells
Authors: Ativui Selase , Danquah Cynthia A. , Ossei Paul Poku Sampene , Ofori Michael 
Published: April 2022

Background: Metastatic breast cancer to the lungs is a serious, life-threatening complication that is difficult to cure. Circulating tumor cells play a key role in the metastatic spread of breast cancer to the lungs via the lymphatic or circulatory system. Palmatine is a protoberberine alkaloid, identified as an active component of traditional African herbal preparations. Palmatine has antimetastatic and antiproliferative effects. The inhibitory activity of palmatine on the metastatic colonization of triple negative breast cancer cells in the lungs was investigated in this study.Methods: 4T1 triple breast cancer cells were transplanted synergically to the thoracic duct of the female balb/c mice via the lymphatic system. Palmatine 1, 5 and 10 mg/kg were administered for 28 days. The lungs were analyzed for levels of arterial blood gas, histological damage, immunohistochemical expression of the metastasis-associated protein 1 (MTA1) and tumor suppressor p53 (p53).Results: Administering palmatine 1–10 mg/kg dose dependently improved hypoxemia, ameliorated metastasis associated lung injury; histology score of 3.33 ± 0.33, 1.67 ± 0.33, 1.33 ± 0.33, decreased lung MTA1 (2.19 ± 0.12, 1.83 ± 0.04, 1.84 ± 0.05) and increased p53 expression (1.99 ± 0.06, 2.27 ± 0.12, 2.34 ± 0.12) respectively.Conclusion: Palmatine preserved lung morphology and demonstrated therapeutic potential in aiding the treatment of lung metastasis.
Early Noninvasive Monitoring of Hypoxic State of Diabetic Foot Based on Diffuse Reflectance Spectroscopy
Authors: Xu Ge , Dong Liquan , Yuan Jing , Zhao Yuejin , Liu Ming , Hui Mei , Kong Lingqin 
Published: April 2022

Early accurate diagnosis and assessment severity of the hypoxic state of diabetic foot is of paramount importance. In this paper, a noninvasive monitoring method of the hypoxic state of the diabetic foot based on diffuse reflectance spectroscopy is proposed. Monte Carlo simulation method is used to imitate the effect on diffuse reflectance of the foot from different blood volume fractions and blood oxygen saturations. Moreover, the in vivo experiments of the hypoxic state of the foot based on the binding method is carried out using an integrating sphere system. Monte Carlo simulation results show that the diffuse reflectance of the foot under normal state and hypoxic state is significantly different. In vivo experimental results are highly consistent with the Monte Carlo simulation results. In vivo experiments further indicate that six characteristic wavelengths (440, 469, 514, 540, 560, and 576 nm) of the diffuse reflectance are more able to distinguish the normal oxygen state and hypoxic states of the foot. The proposed method promotes the development and application of the diffuse reflectance spectroscopy method in the noninvasive detection of biological tissue.
Replacing Dietary Fish Meal with Defatted Black Soldier Fly (Hermetia illucens) Larvae Meal Affected Growth, Digestive Physiology and Muscle Quality of Tongue Sole (Cynoglossus semilaevis)
Authors: Li Xueting , Qin Chuanjie , Fang Zhenzhen , Sun Xueliang , Shi Hongyue , Wang Qingkui , Zhao Honghao 
Published: April 2022

For solving the global shortage of fish meal (FM) supplies from fisheries, the black soldier fly (Hermetia illucens) has become a new protein alternative in aquatic feeds. The present study investigated the effects of dietary inclusion of defatted H. illucens larvae meal (DBLM) on growth, serum biochemical parameters, digestive function, and muscle quality of tongue sole (Cynoglossus semilaevis). The feeding experiment consisted of five experimental diets: a control diet based on FM protein (H0) and four DBLM diets, substituting 25% (H25), 50% (H50), 75% (H75), and 100% (H100) of FM. C. semilaevis (initial weight 563.48 ± 22.81 g) were randomly allocated over five treatments in quadruplicate. After 65 days of feeding, the weight gain rate (WGR), specific growth rate (SGR), and protein efficiency ratio (PER) were significantly higher in H0 and H25 groups with less feed conversion ratio (FCR) and feed intake (FI). The concentrations of serum ALT, TG, T-CHO, ALB, and GLO and their ratio (i.e., A/G) in the H25 group were also significantly higher than those in the other DBLM diet-feeding groups. The digestive enzyme activities first increased (from 25% to 75%) and then decreased (from 75%) with the increased level of DBLM in diets. Meanwhile, there were significant improvements in the thickness of the intestinal longitudinal muscle (LM), circular muscle (CM), columnar epithelium (CE), and lamina propria (LP) in H25 C. semilaevis compared to the control group (p &lt; 0.05). The fish from the other DBLM diets groups presented significant reductions in the thicknesses of LM, CM, CE, and LP, as well as the length of microvilli (ML) in a dose-dependent manner (p &lt; 0.05). However, the substitution of FM increased up to 50% would result in intestinal structural damage. Moreover, the proximate compositions, antioxidant and water holding capacity, and muscular structures of C. semilaevis fillets were all significantly affected after substituting 25% FM with DBLM (p &lt; 0.05). Except for the dry matter, moisture, ash, crude fat, and protein contents were significantly higher in H25 C. semilaevis muscles. The SOD activity in the H0 group was significantly lower than that in the H25 group. The CAT activity in C. semilaevis muscles prominently reduced along with the increase in DBLM content in feeding diets (p &lt; 0.05). The water holding capacity of C. semilaevis fillets was best in the H25 group. In summary, the optimum proportion of DBLM with FM for feeding C. semilaevis may be around 25%.
Acute Endoplasmic Reticulum Stress Induces Inflammation Reaction, Complement System Activation, and Lipid Metabolism Disorder of Piglet Livers: A Proteomic Approach
Authors: Wang Xiaohong , Xin Hairui , Xing Mingjie , Gu Xianhong , Hao Yue 
Published: April 2022

Endoplasmic reticulum stress (ERS) is closely associated with the occurrence and development of many liver diseases. ERS models mostly include experimental animals such as rats and mice. However, pigs are more similar to humans with regards to digestion and metabolism, especially liver construction, yet few reports on ERS in pigs exist. In order to explore changes in the liver under ERS, we used tunicamycin (TM), which can cause liver jaundice and damage liver function, to establish acute ERS models in piglets using a low TM dosage (LD, 0.1 mg/kg body weight (bw)), high TM dosage (HD, 0.3 mg/kg bw), or vehicle for 48 h. We found that both LD- and HD-induced ERS, as verified by the ERS-linked proteins. Furthermore, the concentrations of the proinflammatory cytokines, namely, TNF-α and IL-6 were elevated in TM-treated piglet livers, and the plasma levels of IL-6 and CRP were also higher, indicating the occurrence of inflammation in TM-treated piglets. The complement system was activated in TM-treated piglets, as indicated by increased levels of complement factors and activation products C3, C5a, and AP50. In order to gain insights into the global changes in liver proteins under ERS, we performed an isobaric tag for relative and absolute quantitation (iTRAQ)-based proteomic analysis on the livers of HD- and vehicle-treated piglets. Proteomic analysis identified 311 differentially expressed proteins (DEPs) between the two groups, and a Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis suggested that the DEPs were mainly enriched in signaling pathways such as metabolic pathways, protein processing in the endoplasmic reticulum, and complement and coagulation cascades. Many proteins involved in protein folding, lipid transport, and oxidation were upregulated. Proteins involved in lipid synthesis were downregulated to alleviate liver steatosis, and most complement factors were upregulated to protect the body, and Pearson correlation analysis found that most of the DEPs in the complement and coagulation pathway were significantly correlated with plasma CRP, IL6 and AP50. Our results revealed that TM can activate ERS, marked by liver injury and steatosis, inflammatory reactions, and complement activation in piglets.
Getting Into the Zone: A Pilot Study of Autonomic-Cardiac Modulation and Flow State During Piano Performance
Authors: Jha Shreya , Stogios Nicolette , de Oliveira Adriana Sarmento , Thomas Scott , Nolan Robert P. 
Published: April 2022

BackgroundMusic performance anxiety is a common experience among elite and professional musicians and impedes performers from achieving flow state, or a state of focused, sustained engagement that promotes optimal performance.ObjectiveThe aim of this study was to use heart rate variability (HRV) to determine the psychophysiological underpinnings of optimal music performance.MethodsWe assessed HRV to study how autonomic-cardiac modulation was associated with flow during piano performance. Twenty-two pianists (15–22 years) with at least a Grade 8 Royal Conservatory of Music certification prepared two standardized pieces and a self-selected piece. Performer heart rate data were measured with a Polar 800 watch in 5-min periods immediately before performances, during performances and post-performance. HRV was employed to assess autonomic modulation of cardiac intervals. HRV indices of sympathetic and parasympathetic modulation of the heart were analyzed in 2.5-min segments to monitor short-term autonomic adjustments using the Kubios HRV Software. Flow state was measured using the 36-item Flow State Scale (FSS). Relationships were analyzed using zero-order correlations and multiple linear regressions.ResultsOur sample consisted of 22 RCM Grade 8 certified pianists. Participants achieved the highest level of flow during performance of the Bach piece. Decreased HRV was observed during performance, as indicated by a significant drop in total power. Flow state was positively associated with High Frequency (HF) power during the pre-performance phase, and inversely associated with Low Frequency (LF) power during performance.ConclusionInverse association of flow with LF-HRV during performance affirms the importance of vagal-HR modulation for achievement of flow state. Increased HF-HRV and reduced LF-HRV immediately prior to performance suggests that flow state may be shaped as much by physiological preparation during pre-performance as it is by physiologic responses during performance. Further research is required to validate the correlation between autonomic modulation of the heart and flow state. Evidence of this correlation between autonomic modulation of the heart and achievement of flow state may pave the way for further research on enhancing musical performance and targeting MPA through HRV-based interventions.
Neurobehavioral Dimensions of Prader Willi Syndrome: Relationships Between Sleep and Psychosis-Risk Symptoms
Authors: O'Hora Kathleen P. , Zhang Zizhao , Vajdi Ariana , Kushan-Wells Leila , Huang Zhengyi Sissi , Pacheco-Hansen Laura , Roof Elizabeth , Holland Anthony , Gur Ruben C. , Bearden Carrie E. 
Published: April 2022

BackgroundPrader Willi Syndrome (PWS) is a genetic disorder caused by the absence of expression of the paternal copies of maternally imprinted gene(s) located at 15q11–q13. While the physical and medical characteristics of PWS, including short stature, hyperphagia and endocrine dysfunction are well-characterized, systematic investigation of the long-recognized psychiatric manifestations has been recent.MethodsHere, we report on the first remote (web-based) assessment of neurobehavioral traits, including psychosis-risk symptoms (Prodromal Questionnaire-Brief Version; PQ-B) and sleep behaviors (Pittsburgh Sleep Quality Index), in a cohort of 128 participants with PWS, of whom 48% had a paternal deletion, 36% uniparental disomy, 2.4% an imprinting mutation and 13% unknown mutation (mean age 19.3 years ± 8.4; 53.9% female). We aimed to identify the most informative variables that contribute to psychosis-risk symptoms. Multiple domains of cognition (accuracy and speed) were also assessed in a subset of PWS participants (n = 39) using the Penn Computerized Neurocognitive Battery (Penn-CNB).ResultsIndividuals with PWS reported a range of psychosis-risk symptoms, with over half reporting cognitive disorganization (63.1%) and about one third reporting unusual beliefs (38.6%) and/or suspiciousness (33.3%). Subjectively-reported sleep quality, nap frequency, sleep duration, sleep disturbance, and daytime dysfunction were significant predictors of psychosis-risk symptom frequency and severity (all p's &lt; 0.029). Sleep disturbance ratings were the strongest predictors of psychosis-risk symptoms. Regarding cognition, individuals with PWS showed the most prominent deficits in accuracy on measures of social cognition involving faces, namely Face Memory, Age Differentiation and Emotion Recognition, and greatest slowing on measures of Attention and Emotion Recognition. However, there were no significant differences in psychosis-risk symptoms or cognitive performance as a function of PWS genetic subtype.ConclusionsPWS is associated with a high prevalence of distressing psychosis-risk symptoms, which are associated with sleep disturbance. Findings indicate that self/parent-reported neurobehavioral symptoms and cognition can be assessed remotely in individuals with PWS, which has implications for future large-scale investigations of rare neurogenetic disorders.
Perfil de la desnutrición infantil en Manabí y el rol de las políticas públicas
Authors: Rivera Jairo 
Published: April 2022

La desnutrición infantil es un fenómeno multidimensional que impacta negativamente al desarrollo. En Ecuador presenta prevalencias cercanas a la cuarta parte de la población menor de cinco años, con una limitada reducción a nivel nacional y tiene particularidades a nivel provincial. Esta investigación tiene el objetivo de caracterizar la desnutrición infantil en la provincia de Manabí y el rol de las políticas públicas. Para ello, desarrolla una metodología mixta; lo cuantitativo, usando datos de encuestas de condiciones de vida un análisis de regresión; lo cualitativo, realizando una revisión documental de los planes de desarrollo y ordenamiento territorial. Entre los principales resultados se encuentra que la desnutrición infantil tiene mayor prevalencia para determinados grupos de la población asociados con las causas inmediatas, subyacentes y básicas, donde las políticas públicas han sido limitadas.

Palabras clave: desnutrición infantil, análisis de regresión, políticas públicas.
Autopercepción de la salud laboral en docentes del Instituto Superior Tecnológico Sucre
Authors: Noroña Salcedo Darwin Raul 
Published: April 2022

El objetivo del estudio fue cuantificar e interpretar los indicadores y significados de la autopercepción de salud de los docentes de un Instituto Superior Tecnológico. Estudio mixto. La fase cuantitativa conllevó la aplicación del cuestionario de salud general de Goldberg GHQ-30 a 106 docentes. A través del Chi cuadrado, V de crammer y la razón de momios, se determinó relación entre salud mental y variables sociodemográficas. La fase cualitativa se desarrolló a través de entrevista focal con muestreo propositivo, los ejes temáticos fueron las mismas dimensiones del cuestionario de Goldberg. Como principales resultados: 39 docentes presentaron perturbaciones en salud mental. Las dolencias obedecen a las condiciones de trabajo, cambio de modalidad, aprendizaje de entornos virtuales, precariedad y temor de ser despedidos. Se concluye que la ocurrencia de la pandemia Covid19, incrementó la exposición de factores de riesgo vinculados con las características de la tarea docente afectando la salud mental.

Palabras clave: Salud, teleeducación, estrés, tensión, pandemia.
Analisis Faktor-Faktor yang Mempengaruhi Pendapatan Pedagang Tradisional di Kabupaten Karo (Studi Kasus di Pasar Buah Berastagi)
Authors: Sembiring Jessi Charina 
Published: April 2022

Tujuan umum penelitian ini adalah untuk menganalisis faktor faktor yang mempengaruhi pendapatan pedagang tradisional di pasar buah Berastagi. Kemudian tujuan khususnya yaitu untuk menganalisis pengaruh variabel-variabel seperti Modal Kerja, Lama Usaha, Jenis Barang Dagangan danWaktu Kerja terhadap pendapatan pedagang tradisional di pasar buah Berastagi. Sampel dalam penelitian ini sebanyak 161 pedagang dengan tehnik Simple Random Sampling dengan total populasi 270 pedagang. Metode analisis yang digunakan adalah metode kuadrat linier terkecil (Ordinary Least Square) dengan persamaan regresi linier berganda dengan menggunakan aplikasi Eviews 7. Data yang digunakan dalam penelitian ini adalah dataprimer dan sumber data berasal dari wawancara dan kuesioner yang diberikan kepada pedagang tradisional pasar buah Berastagi.
Hasil penelitian ini menunjukkan bahwa Modal Kerja, Lama Usaha, Jenis Barang Dagangan dan Waktu Kerja secara bersama-sama (simultan) berpengaruh terhadap pendapatan pedagang tradisional di pasar buah Berastagi. Secara parsial, Modal Kerja, Lama Usaha, Jenis Barang Dagangan dan Waktu Kerja berpengaruh positif terhadap pendapatan pedagang tradisional di pasar buah Berastagi dan semua variabel bebas sesuai dengan hipotesis.
PENGARUH PENYALURAN KREDIT, TINGKAT SUKU BUNGA DAN KECUKUPAN MODAL TERHADAP PROFITABILITAS PADA PERUSAHAAN PERBANKAN YANG TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2012-2014
Authors: Simanjorang Jurisman 
Published: April 2022

The main purpose of a company is to make profit. In calculating the benefits made by a banking company, it can use profitability ratios by using a measurement scale; that is, Return on Assets (ROA). Some of the ratios that affect the profitability of a bank include the Loan to Deposit Ratio, Interest Rates and Capital Adequecy Ratio. The research used the theories of financial accounting and banks and other financial institutions with regard to bank earnings and bank capital. The study used a quantitative approach, this type of research is descriptive, and the nature of research is explanotary. Data collection was performed by means of documentation, while data analysis was performed by multiple linear regression analysis. The populations of the study are all banks listed on the Indonesia Stock Exchange (BEI) in the period from 2012 to 2014 totaling 27 companies. The 81 samples of the study were drawn by using purposive technique. The results of this study showed that the value of Adjusted R Square was 15.6% and loan portfolio, interest rates and capital adequacy simultaneously have a significant positive effect on profitability with a significant value of 0.001. And partially, credit does not have any effect on profitability, as well as the interest rate has a significant negative effect on the profitability with the significant value of 0.01 and a capital adequacy has a significant effect on profitability with significant value of 0.01.
Keywords: Lending, Interest Rates, Capital Adequacy, Profitability
ANALYSIS AND ACCOUNTING OF ELECTROMAGNETIC COMPATIBILITY AT THE SHORE STATION OF THE GLOBAL EMERGENCY MARINE COMMUNICATION SYSTEM WHEN PREDICTING THE RANGE OF RADIO COMMUNICATION IN THE MF BAND
Authors: ГРОМОЗДИН В.В. , ИЕВЛЕВ К.В. , КОЗУБ М.С. 
Published: April 2022

Рассмотрена электромагнитная совместимость (ЭМС) берегового приемного оборудования СЧ-диапазона, обусловленная наличием близкорасположенных передающих устройств. Приведена методика расчетного и экспериментально-расчетного определения электродвижущей силы (ЭДС) внутренних шумов приемника, а также ЭДС, приведенной ко входу приемника, обусловленной внешними помехами из-за недостаточной ЭМС. Определен порядок использования полученных значений для прогнозирования дальности радиосвязи в направлении Судно-Берег с учетом ЭМС на береговой станции.
Electromagnetic compatibility (EMC) of onshore receiving equipment of the MF-band, due to the presence of nearby transmitting devices, is considered. A technique for calculating and experimentally calculating the determination of the electromotive force (EMF) of the internal noise of the receiver, as well as the EMF reduced to the receiver input and caused by external interference due to insufficient EMF, is presented. The procedure for using the obtained values for predicting the radio communication range in the ship-to-shore direction, taking into account EMC at the coast station, is determined.
Etiology of Drug-Resistant Epilepsy in Children: a One-Center Retrospective Cohort Study
Authors: Куликова С.Л. , Лихачев С.А. , Козырева И.В. , Белая С.А. , Иванов С.А. , Зайцев И.И. , Савченко М.А. , Попко Р.П. , Талабаев М.В. , Антоненко А.И. , Науменко Д.В. , Свинковская Т.В. , Овсянкина Г.И. 
Published: April 2022

Под фармакорезистентной эпилепсией (ФРЭ) понимают эпилепсию, когда невозможно достичь устойчивого отсутствия эпилептических приступов при использовании двух хорошо переносимых, правильно подобранных в адекватных дозах противосудорожных лекарственных средств в монотерапии или в комбинации. Ретроспективно проанализированы истории болезни 287 пациентов с ФРЭ (139 девочек и 148 мальчиков) в возрасте от 0 до 18 лет, проходивших лечение в Республиканском научно-практическом центре неврологии и нейрохирургии (Минск) с 2014 по 2019 г. Установлены следующие причины развития ФРЭ в педиатрической популяции: 1) приобретенная структурная патология мозга (только структурная эпилепсия) 58 (20,2) наблюдений 2) врожденные пороки развития мозга (структурная генетическая) 70 (24,4) наблюдений 3) структурная патология вследствие перенесенного инфекционного заболевания с поражением ЦНС (структурная инфекционная) 15 (5,2) 4) врожденный порок развития мозга, сочетающийся с постинфекционными изменениями (структурная генетическая инфекционная) 1 (0,3) наблюдение 5) кистозно-атрофические изменения мозга вследствие наследственного заболевания нарушения обмена (структурная генетическая метаболическая) 1 (0,3) наблюдение 6) генетическая без структурного дефекта (генетическая) 66 (22,9) 7) генетическая и метаболическая 5 (1,7) наблюдений 8) аутоиммунная 1 (0,3) 9) неизвестная этиология 70 (24,4) наблюдений.
Drug-resistant epilepsy (DRE) is epilepsy when it is impossible to achieve a stable absence of epileptic seizures using two well-tolerated, correctly selected in adequate doses of anticonvulsant drugs in monotherapy or in combination. The clinical data of 287 patients with DRE (139 girls and 148 boys) aged 0 to 18 years who were treated at the Republican Research and Clinical Center of Neurology and Neurosurgery (Minsk) from 2014 to 2019 were retrospectively analyzed. The following causes of DRE in the pediatric population were established: 1) acquired structural brain pathology (structural epilepsy only) 58 (20.2) cases 2) congenital malformations of the brain (structural genetic) 70 (24.4) cases 3) structural pathology due to an infectious disease with damage to the central nervous system (structural infectious) 15 (5.2) 4) congenital malformation of the brain, combined with post-infectious changes (structural genetic infectious) 1 (0.3) observationcystic-atrophic changes in the brain due to a hereditary disease metabolic disorders (structural genetic metabolic) 1 (0.3) observation 6) genetic without structural defect (genetic) 66 (22.9) 7) genetic and metabolic 5 (1.7) cases 8) autoimmune 1 (0.3) 9) unknown etiology 70 (24.4) cases.