bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisa Implementasi Metode Fuzzy Time Series Jasim pada Prediksi Perkembangan COVID-19 di Indonesia
Authors: Prehanto Dedy Rahman , Permadi Ginanjar Setyo , Nurdiansari Melvin 
Published: February 2022

The pandemic of COVID-19 that has been going on since March 2020 until now has weakened many sectors in many countries an Indonesia as well. In Indonesia, more than 9,000 people have died because of this pandemic. In the first week, 56 cases of COVID-19 were recorded and the cases continued to increase to more than 2,000 cases per week so that the increasing number of cases could result in a lack of service provision and facilities for medical. This study aims to determine the forecasting scheme and how the development of COVID-19 cases that occur in Indonesia. Fuzzy Time Series Jasim method that is applied to find out how to do forecasts by managing previous data. This method uses the determination of the width of the interval, the formation of a set from historical data and using of the average based length method. In this method also used grouping and data relations that have been fuzzified. From the method that has been used, it can be seen that the results obtained from the Fuzzy Time Series Jasim method are obtained from the accuracy rate of the accuracy error using MAD of 286. And the error magnitude of the forecasting results with the actual data using MAPE is 2.43%. Where it can be concluded that the use of Fuzzy Time Series Jasim method in this study provides good forecasting results
A high stability GO nanofiltration membrane preparation by co-deposition and crosslinking polydopamine for rejecting dyes
Authors: Liu Yulong , Huang Zhonghua , Zhang Zhen , Lin Xiaolu , Li Qunxia , Zhu Yihang 
Published: February 2022

Abstract
In order to improve the stability of nanofiltration membrane in separation and purification, a novel polyelectrolyte multilayer nanofiltration membrane was facilely prepared by co-deposition of polydopamine (PDA) and polyethyleneimine (PEI) on the polyethersulfone (PES) ultrafiltration membrane substrate, followed by immersing graphene oxide (GO) solution, and crosslinking PDA. The modified surfaces were characterized using scanning electron microscopy (SEM) and atomic force microscopy (AFM), water contact angle, their saline flux and ability to reject salt and dye were determined. The results also exhibited salt rejection ability as Na2SO4 &gt; K2SO4 &gt; MgSO4 &gt; NaCl &gt; KCl &gt; MgCl2, suggesting the higher rejection of divalent anion. Also, the retention order of the dye by the GO modified membrane is DY86 &gt; DB19 &gt; AG27 &gt; DY142 &gt; DB56 &gt; AR151 &gt; VB5, indicating that the GO modified membrane has better rejection of negatively charged dyes as well as higher molecular weight dyes. Ethanol and hypochlorite resistance tests under different pH conditions showed the membranes coated GO enhanced stability in regard to salt rejection properties. Significantly, the anti-biological test confirmed the growth rate of microalgae on the GO introduced membrane was decreased greatly due to enhanced stability and lower roughness.
The mTOR/4E-BP1/eIF4E Signalling Pathway as a Source of Cancer
Drug Targets
Authors: Maracci Cristina , Motta Stefano , Romagnoli Alice , Costantino Matteo , Perego Paola , Di Marino Daniele 
Published: February 2022

Abstract:
The mechanistic/mammalian target of rapamycin (mTOR) is the crucial hub
of signalling pathways that regulate essential steps in the cell life cycle. Once incorporated
in the mTORC1 complex, mTOR phosphorylates the eukaryotic initiation factor 4E
(eIF4E)- binding protein 1 (4E-BP1), which then releases eIF4E. When not bound to 4EBPs,
eIF4E recognizes the mRNA 5’-cap structure and, together with eIF4A and eIF4G,
it forms the eIF4F complex that recruits the ribosome on the mRNA. Under normal conditions,
the cellular concentration of eIF4E is very low, making eIF4E the limiting factor in
the initiation of protein synthesis. The vast majority of cancer types are characterized by
the simultaneous deregulation of the mTOR/4E-BP1 signalling pathway and upregulation
of eIF4E, which lead to an increased expression of cancer-promoting genes and
deregulated cellular growth. Over the last decades, a growing number of selective inhibitors
of the mTOR/4E-BP1/eIF4E pathway have been discovered or designed. Several inhibitors
with encouraging preclinical results have been tested in clinical trials. This review
summarizes the most recent research on drug development against mTOR, 4E-BP1,
and eIF4E, describing the design rationale and the available structural and functional data
on the most promising compounds.
Design, Synthesis, and Biological Activity of a Novel Series of 2-Ureidonicotinamide
Derivatives Against Influenza A Virus
Authors: Zhang Chao , Xiang Jun-Jie , Zhao Jing , Meng Yan-Li , Zhang Fu-Rong , Jin Zhe , Shaw Pang-Chui , Liu Xiao-Ping , Hu Chun 
Published: February 2022

Background:
Viral resistance to existing inhibitors and the time-dependent effectiveness
of neuraminidase inhibitors have limited the number of antivirals that can be
used for prophylaxis and therapeutic treatment of severe influenza infection. Thus, there
is an urgent need to develop new drugs to prevent and treat influenza infection.

Objective:
The aims of this study was to design and synthesize a novel series of 2-ureidonicotinamide
derivatives and evaluate their anti-IAV activities. Furthermore, we predicted
the abilities of these compounds to inhibit the PA-PB1 subunit and forecasted the
docking poses of these compounds with RNA polymerase protein (PDB ID 3CM8).

Method:
The novel designed compounds were synthesized using classical methods of organic
chemistry and tested in vitro for their abilities inhibiting RNP and against influenza
A virus. In addition, the 23 synthesized molecules were subjected to the generated pharmacophore
Hypo1 to forecast the activity target PA-PB1 subunit of RNA polymerase.
The ADMET pharmacokinetic parameters were calculated by the ADMET modules in
Discovery Studio 2016. The docking results helped us demonstrate the possible interactions
between these compounds with 3CM8.

Results:
The synthesized 2-ureidonicotinamide derivatives were characterized as potent
anti-influenza inhibitors. The target compounds 7b and 7c demonstrated significant antiviral
activities and could be considered as novel lead compounds of antiviral inhibitors.
In addition, compound 7b revealed suitable ADME properties expressed and might be a
significant RNA polymerase inhibitor targeting the PA-PB1 subunit based on the predictable
results and the docking results.

Conclusion:
This study revealed a novel series of compounds that might be useful in the
search for an effective drug against the influenza virus.
Selenium-Derivative Compounds: A Review of New Perspectives in the Treatment of Alzheimer’s Disease
Authors: Barbosa Flavio A.R. , Canto Rômulo F.S. , Teixeira Kerolain F. , de Souza Anacleto S. , de Oliveira Aldo S. , Braga Antonio L. 
Published: February 2022

Background:Alzheimer’s disease (AD) is one of the most prevalent types of dementia, affecting millions of older people worldwide. AD is stimulating efforts to develop novel molecules targeting its main features associated with a decrease in acetylcholine levels, an increase in oxidative stress and depositions of amyloid-β (Aβ) and tau protein. In this regard, selenium-containing compounds have been demonstrated as potential multi-targeted compounds in the treatment of AD. These compounds are known for their antioxidant and anticholinesterase properties, causing a decrease in Aβ aggregation.Objective:In this review, we approach structure-activity relationships of each compound, associating the decrease of ROS activity, an increase of tau-like activity and inhibition of AChE with a decrease in the self-aggregation of Aβ.Methods:We also verify that the molecular descriptors apol, nHBAcc and MlogP may be related to optimized pharmacokinetic properties for anti-AD drugs.Results:In our analysis, few selenium-derived compounds presented similar molecular features to FDA-approved drugs.Conclusion:We suggest that unknown selenium-derived molecules with apol, nHBAcc and MlogP like FDA-approved drugs may be better successes with optimized pharmacokinetic properties in future studies in AD.
Construction and Validation of an Immune-Related lncRNA Prognosis
Model for Thyroid Cancer
Authors: Nian Weiqi , Li Zheng , Wang Hui , Deng Xia , Zhang Jing , Wang Ling , Tang Wanyan , You Wenxin 
Published: February 2022

Background:
Immune-related long noncoding RNAs (lncRNAs) play an important role
in the development of cancer. This study aimed to identify immune-related lncRNAs in thyroid
cancer (THCA) and develop a prognostic model for THCA.

Method:
We downloaded immune-related gene sets from the Gene Set Enrichment Analysis
(GSEA) website and obtained THCA gene expression and clinical data from The Cancer Genome
Atlas (TCGA) database. Immune-related lncRNAs were then obtained by performing correlation
analysis on the expression of lncRNAs and immune-related genes. A prognostic model for THCA
immune-related lncRNAs was developed through univariate Cox regression and multiple Cox regression
analyses. We confirmed the results in clinical samples using quantitative real-time PCR.

Results:
A total of 26 immune-related lncRNAs in THCA were obtained. Then we constructed a
prognosis model composed of seven lncRNAs (LINC01614, AC017074.1, LINC01184,
LINC00667, ACVR2B-AS1, AC090673.1, and LINC00900). Our model can be used as an independent
prognostic factor. Principal component analysis displayed that the lncRNAs in the model
can distinguish between high and low-risk groups. Clinical correlation analysis showed that the expression
levels of AC090673.1 (P<0.05), LINC01184 (P<0.001), and LINC01614 (P<0.001) were
related to disease stage, and LINC00900 (P<0.001) and LINC01614 (P<0.001) were related to T
stage. We validated this model in cancer and paracancerous tissues from 24 THCA patients.

Conclusion:
We identified and experimentally validated seven immune-related lncRNAs that can
serve as potential biomarkers for THCA prognosis.
Sweet’s Syndrome: An Update
Authors: Agrawal Amit , Arif Salahaldin Hafud , Kumarasan Krithika , Janjua Dalwinder 
Published: February 2022

Abstract:
Sweet’s syndrome is a serious dermatological disorder characterized by a rapid onset of tender plaques or nodules, fever, joint pain, headache, and oral and genital lesions. According to the clinical features and underlying causes, Sweet’s syndrome is divided into three categories, i.e., classi-cal (or idiopathic), malignancy-associated Sweet's syndrome, and drug-induced Sweet's syndrome. It is multifactorial in etiology, and the exact cause is still undetermined. The diagnosis can be confirmed by the routine histopathologic evaluation of skin biopsy from the lesions. The first-line treatment options are topical and systemic steroids. Multiple databases, like Medline/PubMed, Scopus, and Google, were used to identify resources for this literature review. The relevant information was col-lected from various case reports, case series, reviews, meta-analyses, and large clinical trials reporting clinical description, etiology, diagnosis, and management of Sweet’s syndrome. This narrative review aimed to discuss recent understandings related to Sweet's syndrome, both in terms of clinical presen-tation and management approach.
Impact of Diabetes in COVID-19 Associated Mucormycosis and its Management:
A Non-Systematic Literature Review
Authors: Nair Sreedharan , Rashid Muhammed , Rajan Asha K. , Thunga Girish , Shanbhag Vishal 
Published: February 2022

Background:
COVID-19 has become extremely dangerous manifesting itself in a variety
of forms ranging from a simple flu-like illness to death. COVID-19 associated mucormycosis
(CAM) is a global threat with diabetes being a major contributor.

Objective:
This review aims to give a clear picture of the impact of hyperglycemia in CAM along
with its management.

Method:
Google and Google Scholar were searched and studies that addressed the impact of diabetes
in CAM were considered for this review. We also performed a bibliographic search of the
specific article to find additional studies.

Results:
A series of events such as unregulated activation of innate immune system modification,
pro-inflammatory M1 macrophages activation, and the depletion of natural killer cell activity is
very common in patients with COVID-19. In addition, the exacerbated cytokine syndrome and hyperinflammatory
response may elevate the severity of this condition, which further leads to higher
mortality. The impaired immune phase which follows provide the niche for increased infection
among diabetic patients making them more prone towards developing mucormycosis and associated
infections. Early detection, surgical debridement, and appropriate medical treatment with antifungals
and hypoglycaemic agents may help control the infection and associated morbidity and
mortality. COVID-19 drugs, hypoglycaemic agents, antifungals, and comorbidities have all been
associated with adverse side effects and drug interactions.

Conclusion:
Clinicians should be well aware of this deadly disease and manage COVID-19, diabetes,
and mucormycosis through individualized treatment regimens to improve patient outcomes.
Stress Etiology of Type 2 Diabetes
Authors: Sunena  , Mishra Dina Nath 
Published: February 2022

Abstract:
Stress creates disharmony in the body's natural environment and thus causes an imbalance
in the normal physiological system. The term diabetes describes a group of metabolic disorders,
characterized and identified by the presence of hyperglycemia. Essential factors identified to
initiate hyperglycemia are excess body weight, high cholesterol, high blood pressure, and lifestyle
changes like stress, genetics, etc. Different types of stress and related conditions like depression,
anxiety, etc., cause pancreatic β-cell dysfunction and insulin resistance, the prime risk factors in the
progression of type 2 diabetes. The neuroendocrine system plays a pivotal role in countering psychological
stress is the hypothalamus-pituitary-adrenal (HPA) axis, which secretes glucocorticoids
(GCs), e.g., cortisol is the principal stress-responsive natural steroid hormone. The stress system
essentially hampers the body's homeostasis and develops serious clinical manifestations. Glucocorticoids
exert a strong physiological impact on glucose metabolism directly or indirectly, cause hyperglycemic
effect and play an important role in the development of type 2 diabetes observed in
patients suffering from chronic stress, Cushing’s syndrome, or patients on long term GCs therapy.
This review provides a clear outline on the pathways and mechanisms of stress-linked type 2 diabetes.
Ultrasonic Assisted Synthesis, Biological Evaluation, and Molecular Docking of Chalcone-based 1,5-benzodiazepine as Potential Anticonvulsant Agents
Authors: Rajkumar Thangavelu , Kumar Solleti V. Suresh , Srinivasan Nagarajan 
Published: February 2022

Background:Epilepsy is a constant neurological disorder influencing around 50 million individuals globally. However, most epileptic patients do not react to accessible medications and clinical treatments. This research work has been planned to produce novel 1,5-benzodiazepines from chalcone intermediates by ultrasonic irradiation method and perform the anticonvulsant activity by pentylenetetrazole incited seizures tests.Method:Chalcones are used as precursors for synthesizing 1, 5-benzodiazepines by a reaction with ophenylenediamine in absolute ethanol in the presence of glacial acetic acid as a catalyst. The proposed synthesized structures were characterized by melting point, TLC, FTIR, 1H & 13CNMR, and mass spectroscopy. All the molecules were assessed for anticonvulsant activity.Result:Anticonvulsant activity uncovered the fact that the mixes derived from dimethylamino, dimethoxy, hydroxy-substituted chalcones in the 1, 5-benzodiazepines can be used for seizures in mice. These pharmacological examinations have shown that these new subsidiaries can repress seizures incited by pentylenetetrazole in mice proficiently. Our molecular docking studies also supported probable effects.Conclusion:The results are promising, which on further assessments may provoke medicine particles against seizures in mice.
Evaluation of Antiproliferative Activity of Lac Dye Fractions against MDA-MB-231
and SiHa Cell Lines
Authors: Dagur Pankaj , Ghosh Manik 
Published: February 2022

Background:
Laccifer lacca (Kerr) produces a mixture of polyhydroxy anthraquinones (laccaic acid) known
as lac dye. Literature suggests that these laccaic acids have a structural resemblance with the anticancer drug Adriamycin
(ADR). Hence, they may possess potential anticancer activity.

Method:
This study was designed to explore the in vitro anticancer activity of the three fractions of lac dye, i.e., chloroform
(C), methanol (M), and water (W) fractions, and isolation of constituents from bioactive fraction.

Results:
SRB (Sulforhodamine B) assay method was employed to evaluate the inhibitory action of all three fractions.
However, only methanolic showed promising inhibitory action with GI50 <10; this runs in parallel with Adriamycin
inhibition (GI50 <10). Two active constituents of the methanolic extract were isolated using column chromatography
and were characterized using UV (UV visible spectrophotometer), IR (Infrared spectroscopy), NMR (nuclear magnetic
resonance), and mass spectrometry methods. The final structure of the isolated constituents (laccaic acid D and laccaic
acid B) was confirmed by 13C and 2D NMR data.

Conclusion:
Conclusively, only the methanol fraction (M) showed promising anticancer activity against in vitro MDAMB-
231 and SiHa cell lines compared to the standard adriamycin.
Leksikon dalamTradisi Sib Mimnyen (Cacing Laut/Nyale) di Kabupaten Halmahera Tengah
Authors: Kamal Ashryani Sitinur M. , Cholsy Hayatul 
Published: February 2022

This research was conducted to explore lexicon naming used in sib mimnyen tradition and the relationship with social values, community beliefs, and social activities. Data were collected using documentation techniques obtained from portraits of daily life and interviews with local communities. The research sample was randomly selected using random sampling technique. The results of this study found that the naming of nyale (marine worms) is influenced by several aspects such as language relation (Patani language in North Maluku - Thai Pattani language in Thailand), and the way of proccessing the worm, cognates vocabulary spesifically the sounds, and marine worm habitat. Furthermore, there were also non-language factors that supported determinism of sib mimnyen tradition consist of geographical location and social activities.
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Penelitian ini dilakukan dengan tujuan untuk menelisik penamaan leksikon yang digunakan dalam tradisi sib mimnyen dan hubungannya dengan nilai-nilai sosial, kepercayaan masyarakat, dan aktifitas sosial. Data dikumpulkan dengan menggunakan teknik dokumentasi yang diperoleh dari potret kehidupan sehari-hari dan wawancara terhadap masyarakat setempat. Sampel penelitian ini dipilih secara acak menggunakan teknik pengambilan sampel purposif. Hasil penelitian ini ditemukan penamaan nyale (cacing laut) dipengaruhi oleh beberapa aspek seperti hubungan kata antarbahasa (bahasa Patani Maluku Utara – bahasa Pattani Thailand), antarproses pengolahan, antarbunyi kosakata yang serupa (cognates vocabulary), dan habitat cacing laut. Selain itu, ditemukan juga faktor non bahasa yang menopang detrminasi budaya dalam tradisi sib mimnyen diantaranya letak geografis dan aktivitas sosial masyarakat.
Retensi dan Inovasi Fonologis Protobahasa Austronesia (Pan) pada Bahasa Sumbawa (Bs)
Authors: Wahid Mardiah Husnul Fitri 
Published: February 2022

Penelitian ini bertujuan mendeskripsikan fonem PAN yang mengalami retensi dan inovasi fonologis pada bahasa Sumbawa (BS) ditinjau dari persepektif diakronis. Data yang digunakan sebanyak 200 kosakata. Pengumpulan data lapangan dilakukan dengan metode simak dan cakap dengan teknik catat dan rekam, metode cakap semuka dengan menggunkan teknik dasar pancing dengan teknik bawahan catat, dan rekam. Data dianalisis dengan menerapkan metode kualitatif deduktif dengan menggunakan metode inovasi bersama dan metode komparatif. Hasil penelitian secara diakronis menunjukkan empat vokal mengalami retensi yaitu /i/, /u/, /a/, /e/, dan terdapat 15 fonem konsonan yang mengalami reesi yaitu /p/, /b/, /t/, /d/, /k/, /g/, /m/, /n/, /ŋ/, /ñ/, /s/, /r/, /l/, /w/, /y/. Sedangkan untuk fonem PAN yang mengalami inovasi pada BS terdapat beberapa fonem, yang mana beberapa fonem inovasi teratur dan tidak teratur (sporadis). Adapun fonem PAN yang mengalami inovasi tidak teratur atau sporadis yaiu *i > e, *u > o, *b > p,w, dan *ə > ə, e, ɛ. sedangkan inovasi teratur fonem PAN pada BS yaitu *z > j, *j > d, t, *w > ø, dan *y > ø, inovas kerap terjadi pada posisi awal dan antarvokal pada BS.
IMPEACHMENT E RESPONSABILIDADE JURÍDICA
Authors: Resende Ranieri L. 
Published: February 2022

Visa o artigo à análise do impeachment em sua posição de mecanismo de controle institucional de agentes políticos, a partir da busca por suas bases teórico-históricas oriundas do common law. O enfrentamento do problema da definição da(s) natureza(s) do impeachment objetivou, em primeiro lugar, situar a questão da responsabilidade na abrangência teórica da democracia representativa, face às falhas que lhe são imanentes com relação a desvios de expectativas e abusos de poder. Ao identificar distinções estruturais entre as responsabilidades política (accountability) e jurídica, configurou-se adequado resgatar historicamente o requisito da violação de lei nos precedentes atenienses clássicos (eisangeliai). As mutações sequenciais vinculadas ao impeachment perpassaram as fases de: a) estabelecimento de parâmetros procedimentais (primeiros casos); b) exigência do critério de juridicidade (período Stuart); c) busca por especificação das hipóteses de cabimento (EUA); d) fixação de tipos legais precisos de violação (Brasil). Sob o prisma histórico-comparado, evidenciou-se nítido o crivo de juridicidade qualificada adotado no primeiro modelo normativo do impeachment presidencial brasileiro (1891-1892).
CITRA WANITA ARAB DAN EROPA DALAM NOVEL 'ILLA FATIMAH' KARYA ANIS MANSOUR: KRITIK SASTRA FEMINIS
Authors: Dian Insani Hermawati Putri 
Published: February 2022

This study examined the images of Arabian and European women in the novel Illa Fatimah written by Anis Mansour. To describe the women's images, this study applied Â structural analysis method and ideologist feminism literature criticism approaches. It as intended to Â reveal the female characters and stereotypes in the novel The method of this research was descriptive-qualitative since the data of this study were textual in the forms of words, phrases, clauses, sentences showing the intrinsic and extrinsic elements of the novel. The result of this study showsthat there are some differences between Arabian and European woman images both in physical and psychological aspects as well as in their families and communities.