bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of QTc interval prolongation in patients treated for covid-19 with Doubase C or Hydroxychloroquine-azithromycin at University Hospital of Kinshasa
Authors: Madioko Brady Makanzu , Rissassi Jean-Robert Makulo , Mihigo Constantin Bashengezi , Kurhenga Gilbert Kabanda , Mwilambwe Benjamin Kabue , Kasago Freddy Mugisho , Mufungizi Jeancy Ngaboyeka , Khonde Stanilsas Nsasi , Ezabika Christian Bashengezi , Okwé Augustin Ngé , Longo-Mbenza Benjamin 
Published: November 2022

Abstract
Background: QTc prolongation has been described in COVID-19 patients treated with Hydroxychloroquine (HCQ) and Azithromycin (AZT) in western countries. In the Democratic Republic of the Congo (DRC), few studies have assessed the safety of these molecules, and neither have they for new molecules proposed for COVID-19 treatment, such as Doubase C. This study aimed to determine the incidence of QTc prolongation in COVID-19 patients treated with HCQ-AZT or Doubase C.
Methods: This study was part of a randomized clinical trial. Data were collected from May 20, 2021, to January 15, 2022. Patients were randomized into two arms; one was treated with Doubase C and the other with HCQ-AZT at standard dosages. Only patients with mild to moderate COVID-19 were included.
Results: A total of 261 patients were included. At inclusion, the two groups were comparable (52.5% men, 47.5% women, mean age 41±15 years. The incidence of prolonged QTc interval was 1.5% in the whole group (3.3% on the HCQ-AZT arm and 0% on the Doubase C arm). No ventricular arrhythmias or torsade de pointes, or cardiac arrest were observed.
Conclusion: Unlike Doubase C, the HCQ-AZT strategy has a risk of QTc prolongation.
Knockout of formyl peptide receptor 1 reduces osteogenesis and bone healing
Authors: Yang Xinlin , Xiao Wan'an , Le Quang , Lee Sang-Hyun , Dighe Abhijit , Kerrigan Jason R , Cui Quanjun 
Published: November 2022

Abstract
Background
Formyl peptide receptor 1 (FPR1), a key member of Formyl peptide receptors (FPRs) from a G-protein coupled receptor family, was previously well-characterized in immune cells. But the function of FPR1 in osteogenesis and fracture healing was rarely reported. In this study, using the FPR1 knockout (KO) mouse, for the first time, we demonstrated a close correlation of FPR1 function to osteogenic differentiation of bone marrow-derived stem cells (BMSCs) in vitro and bone fracture healing in vivo.
Methods
Primary BMSCs were isolated from both FPR1 KO and wild type (WT) mice. Osteogenic markers were detected during osteogenic differentiation of BMSCs. Biomechanical and structural properties of femur were compared between healthy WT and KO mice by mechanical test and microcomputed tomographic. A closed, transverse fracture at the femoral midshaft was created to compare bone healing between KO and WT mice.
Results
The FPR1 mRNA level increased significantly during osteogenesis of BMSCs. More importantly, compared to BMSCs from FPR1 KO mice, WT BMSCs expressed significantly higher levels of common osteogenic markers as well as mineralization at day 14 and 21. In addition, the femur from WT mice had better biomechanical and structural properties than the femur from FPR1 KO mice. Furthermore, at day 35 following femur fracture, bone healing in WT mice was remarkably improved compared to FPR1 KO mice, demonstrated by X-ray appearance, H&E stain, bone density, and bone volume/total volume.
Conclusion
FPR1 plays an important role in osteogenic differentiation, bone mechanical strength, and regenerative capacity of fractured bone. Knockout of FPR1 reduces osteogenesis and bone healing in vivo and vitro.
Direct enantioselective allylation of nitriles to NH2-α-tertiary amines
Authors: Li Qing , Shi Yinrui , Li Jiuling , Guo Yafei , Fan Baomin 
Published: November 2022

Abstract
Organic molecules, containing one or more amine chiral centers, are pretty common to see in natural products and medicines. Although a large number of methods have been developed to afford enantiopure amines, most of the known approaches are limited with various reasons. For example, many methodologies start from nitrogen protected and activated substrates, which usually need multistep operations and seriously decrease the atom economy. Here we disclose a new catalytic three-component strategy from commercial nitriles directly to high enantioselective a-tertiary primary amines in up to 90% yield and 95% enantiomeric excess. This transformation firstly undergoes an addition process of organolithium reagents to nitrile to generate the imine intermediate in situ. Subsequently, the most challenging step is by employing copper catalytic enantioselective addition of AllylBpin to the lithium imine intermediate to form the final amine in one pot.
Deep-trap Dominated Degradation of the Endurance Characteristics in OFET memory with Polymer Charge-Trapping Layer
Authors: Yu Tianpeng , Liu Zhenliang , Wang Yiru , Zhang Lunqiang , Hou Shuyi , Wan Zuteng , Yin Jiang , Gao Xu , Wu Lei , Xia Yidong , Liu Zhiguo 
Published: November 2022

Abstract
Organic field-effect transistors (OFETs) with polymer charge-trapping dielectric, which exhibit many advantages over Si-based memory devices such as low cost, light weight, and flexibility, still suffer challenges in practical application due to the unsatisfied endurance characteristics and even the lack of fundamental of behind mechanism. Here, we real that the degradation of endurance characteristics of pentacene OFET with poly(2-vinyl naphthalene) (PVN) as charge-storage layer is dominated by the deep hole-traps in PVN by using the photo-stimulated charge de-trapping technique with the fiber-coupled monochromatic-light probes. The depth distribution of hole-traps in PVN film of pentacene OFET is also provided.
Comparison of recommendations from cirrhosis Clinical Practice Guidelines and from Cochrane systematic reviews
Authors: Roberts Danielle , Leung Jeffrey , Gluud Christian , Nikolova Dimitrinka , Pavlov Chavdar , Davidson Brian , Gurusamy Kurinchi 
Published: November 2022

Abstract
Background: Clinical practice guidelines (CPGs) contain recommendations intended to aid clinicians in providing optimal care for patients and should be derived from the best quality evidence available. The highest quality evidence is obtained through systematic reviews using Cochrane methodology. This exploratory study aimed to determine the proportion of guideline statements from major liver organisations in USA and Europe that were consistent with the conclusions of recent systematic reviews using Cochrane methodology.
Methods: We selected four topics related to decompensated cirrhosis on which our group has recently published Cochrane systematic reviews (variceal bleeding; spontaneous bacterial peritonitis; ascites; hepatorenal syndrome). We performed a purposive sample of CPGs from leading organisations covering these topics: American Association for the Study of Liver Diseases (AASLD); British Society of Gastroenterology (BSG); European Association for the Study of the Liver (EASL); and National Institute for Health and Care Excellence (NICE) until January 2022. For each guideline recommendation statement, two researchers independently assessed whether there was agreement in the statement and the strength of recommendation given by guideline authors when compared to those derived from the Cochrane reviews. We meta-analysed the proportion of agreement using ‘meta’ package for R utilising the ‘Generalised Linear Mixed Model’ method for meta-analysis of proportions.
Results: We identified 9 CPGs containing 62 guideline statements that were also covered in 7 Cochrane reviews. Agreement between the guideline authors and independent assessment was 0.145 (95% CI: 0.077 to 0.256), i.e., there was disagreement in 85.5% of recommendation statements. There was disagreement on four of the 62 guideline statements about the use or consideration of an intervention when there was no evidence to support their use or consideration. The remaining disagreements related to the disagreement in the strength of recommendation: in each of these disagreements, the guideline author had provided a strong recommendation for or against an intervention when there was only weak evidence for or against the intervention. For each disagreement in the strength of recommendation, the strength of recommendation was overstated rather than understated by the guideline authors. The disagreement could not be explained by the difference in the search dates between the guidelines and Cochrane reviews.
Conclusion: The strength of recommendation given in the majority of CPGs from leading liver organisations on decompensated liver cirrhosis did not match those derived from Cochrane reviews. Our findings suggest a systematic issue with guideline developers overstating the strength of recommendations, which has the potential for direct impact on patient care.
External and limited internal fixation in the treatment of open Gustilo-Anderson Grade III ankle fractures: A single-center retrospective cohort study
Authors: Zheng Lei , MU Weidong , Xu Peng 
Published: November 2022

Abstract
Background
The treatment of Gustilo-Anderson grade III open distal tibia fractures remains controversial, and often results in serious complications, including amputation. External fixation combined with limited internal fixation (EFLIF) can provide stability and exert beneficial effects on the fracture. This study evaluated the functional and clinical outcomes of EFLIF in patients with Gustilo-Anderson grade III open distal tibia fractures.
Methods
We retrospectively reviewed the clinical and follow-up data of 36 patients with open distal tibia fracture treated in our hospital between January 2017 and July 2021. We excluded cases lost to follow-up and those who underwent amputation. The data analysis included 26 patients with Gustilo-Anderson grade III fractures. The patients were followed up for traumatic surface recovery, ankle complications, and ankle function. The American Orthopedic Foot & Ankle score (AOFAS) was used to evaluate the functional outcomes.
Results
The 26 patients were followed up for 6–24 (mean, 14) months. Based on the AOFAS, the outcome in 17 patients was excellent, good in five, medium in three, and poor in one. No patient experienced incision breakdown, postoperative infection, or fracture nonunion.
Conclusion
The EFLIF can achieve positive outcomes when used to treat open distal tibia fractures. Sometimes, it can be considered the first line of treatment for open distal tibia fractures.
Sex-Specific Disruption in Human Placental miRNAs and mRNAs Involved in IUGR Placental Insufficiency and Capillary Angiogenesis
Authors: Song Wenhui , Guo Qing , Puttabyatappa Muraly , Elangovan Venkateswaran Ramamoorthi , Wang Jianping , Li Fang , Liu Fangfang , Bi Xuejie , Li Haiying , Fu Guangping , Padmanabhan Vasantha , Wu XiaoHua 
Published: November 2022

Abstract
Intrauterine growth restriction (IUGR) is one of the most common pregnancy complications culminating in adverse fetal outcome, including preterm birth, neonatal mortality and stillbirth. Compromised placental development and function, especially disruption in angiogenesis and inadequate nutrient supply are contributing factors. Fetal sex also influences placental function. Knowledge of gene expression changes and epigenetic factors contributing to placental dysfunction in IUGR pregnancies will help identify biomarkers and help target interventions. This study tested the hypothesis that IUGR pregnancies are associated with sexually-dimorphic disruptions in miRNA - an epigenetic factor and mRNAs invloving key mediators of angiogenesis and microvessel development. Changes in expression of key genes/proteins involved in placental dysfunction by RT-PCR and immunohistochemistry and miRNA changes by RNA sequencing were undertaken with term placenta from 12 control and 20 IUGR pregnancies. Findings showed sex-dependent changes in expression of genes involved in steroidogenesis, steroid action, IGF family members, inflammatory cytokines and angiogenic factors in IUGR pregnancies. In addition, upregulation of MIR451A and downregulation of MIR543 in placentas from IUGR group with female newborns and upregulation of MIR520G in placentas from IUGR group with male newborns were also noted. MIR451A and MIR543 have been implicated in angiogenesis. Consistent with gene changes, CD34, the microvessel angiogenesis marker, also showed reduced staining only in female IUGR group. These findings provide evidence in support of sexual dimorphism in the capillary development of IUGR manifested at the level of key mediators of placental angiogenesis and placental function that include changes in expression of miRNA with potential to serve as biomarkers.
Safety and efficacy of atosiban: a systematic review and a meta-analysis of randomized controlled trials and observational studies
Authors: Zhang Yi , Feng Xin 
Published: November 2022

Abstract
Background: Atosiban has shown ameliorative effects in preterm birth (PTB), repeated implantation failure, and breech delivery by suppressing contractions, but its safety profile has not been fully established.
Methods: Published randomized controlled trials and observational studies was electronically searched from inception to September 1, 2022. Our primary outcomes were maternal adverse events and neonatal comorbidities. Random effects model was used for data synthesis, and pooled risk ratios (RRs) with corresponding 95% confidence intervals (CIs) were calculated.
Results: 43 studies comprising 11,772 patients were identified eligible. The incidence of maternal adverse events in atosiban group and controls were 4.0% and 12.4%, respectively. Overall, the risk of maternal adverse events and the discontinuation of treatment due to adverse events were significantly lower with atosiban compared with controls (RR 0.38, 95% CI [0.23, 0.61], P < 0.0001; RR 0.11, 95% CI [0.04, 0.29], P < 0.00001; respectively). The incidence of neonatal comorbidities was similar, and a higher risk of neonatal apnoea was observed in atosiban group compared with controls (RR 1.40, 95% CI [1.04, 1.90], P = 0.03).
Conclusion: Atosiban has comparable efficacy and substantial better safety profile in the management of PTB, in vitro fertilization-embryo transfer (IVF-ET) and external cephalic version (ECV) compared with controls. Additionally, awareness of the presence of neonatal apnoea is required. In clinical practice, the appropriate treatment regimen needs to be selected according to the local circumstances and the individual patient condition.
Supplementation of carbohydrate enzymes plus protease to the diet of finishing pigs containing 2 protein levels on the effects of growth performance, toxic gas emissions, meat quality, and colonic microbiota community
Authors: Zhang Qianqian , Cho Sungbo , Song Junho , Jeong Jinuk , Yu Minjae , Mun Seyoung , Han Kyudong , Kim Inho 
Published: November 2022

Abstract

Background Dietary supplementation with exogenous enzymes may positively affect the traits of finishing pigs. The present study investigated the effects of different protein levels and exogenous carbohydrate enzymes plus protease on growth performance, meat quality, toxic gas emissions, and the structure and function of colonic microbiota in finishing pigs.
The correlation between bank risk, performance, and regulatory capital for Conventional banks in golf cooperation countries
Authors: BENALI Wissem , mhamid imen 
Published: November 2022

AbstractThis article aims at illustrating the link between the bank risk, regulatory capital, and the bank performance. By using a panel dynamic data in the GMM estimator on a large dataset of 73 banks belonging to Golf Cooperation Countries from 2000 to 2018, we have discovered that both the regulatory capital and the bank performance have a negative association with bank risk. Thus, we have analyzed the link between the bank risk and the bank performance on regulatory capital and discovered that the bank risk negatively influences the bank performance. However, with banks with larger capital ratios the bank performance improves noticeably. Finally, we finished by demonstrating the impact of the financial crisis on these relationships, and our robustness check confirms our major findings.
What is the Impact of Vitamin D Levels on COVID-19 Severity?: A Systematic Review
Authors: Kersh Lydia , Geary Kyla , Roberts Michael , Daghigh Farzaneh 
Published: November 2022

Abstract
Keywords:
Vitamin D, Covid-19
BACKGROUND
COVID-19, a novel virus, was first discovered in 2019. It is a respiratory disease caused by SARS-CoV-2. It has been suspected that vitamin D levels play an important role in the immune response to respiratory illnesses causing the attenuation of infection. Considering this, vitamin D levels have also been found to have a similar effect on patients infected with COVID-19.
Application and Research of Basketball Footwork Supported by Intelligent Edge Cloud Computing and Deep Learning Unsupervised Transfer Method
Authors: Sun Hui , Gao Meng 
Published: November 2022

Abstract
Basketball is a comprehensive physical sport in which footwork migration is the key point. To explore the current teaching status of basketball footwork mobile, Deep Learning (DL) and unsupervised transfer methods are combined to extract the footwork movement characteristics of basketball players for data analysis and research. At the same time, to effectively analyze the feature data of the collected player footwork, intelligent edge cloud computing is used to carry out advanced processing on the extracted data features, and Convolutional Neural Networks (CNNs) are employed to perform transfer learning on the extracted target domain samples. Feature extraction is performed on the data, and the impending action of a basketball player is predicted. Meanwhile, the unsupervised human action transfer method is studied to provide new ideas for basketball footwork action series data modeling. Finally, the theoretical framework based on intelligent edge cloud computing and DL unsupervised transfer method is summarized. Its principle is explored and applied in the teaching of basketball footwork. The results show that: (1) The converged convolutional network and classification network parameters can predict players’ movement trajectories. (2) Compared with the existing supervised learning methods on synthetic datasets, unsupervised training using network data dramatically increases the variety of actions during training. (3) The classification accuracy of the transfer learning method is high, and it can be used for the different basketball footwork in the corresponding stage of the court.
Suitability evaluation of land reclamation as arable land in coal mining area based on catastrophe theory
Authors: Li Yinghui 
Published: November 2022

Abstract

A catastrophe progression model for the suitability evaluation of land reclamation as arable land in coal mining area was put forward based on the catastrophe theory. The suitability classification of land reclamation as arable land in coal mining area was divided into four grades: suitable, moderately suitable, less suitable, and unsuitable. On the basis of comprehensive consideration of three factors including land quality, soil nutrients and engineering suitability in the reclamation area, eleven parameters including terrain slope grade, effective thickness of soil layer, soil parent materials, soil contamination, organic content, alkali hydrolyzable nitrogen (N), available phosphorus (P), available potassium (K), ground collapse, land destruction extent, and conditions of irrigation and drainage were selected as evaluation indicators, and the classification standards of each evaluation indicator was determined. Using MATLAB software to generate 800 total samples (200 samples per level) between the arrays corresponding to each level of standards according to the principle of normal distribution, of which 600 were used as training samples to establish the catastrophe progression criteria, and 200 were used as test samples to verify the reliability of the proposed criteria, and the proposed criteria also were verified by engineering examples. The suitability of land reclamation as arable land in coal mining area in Shaodong county, China, was comprehensively evaluated by using the proposed model. The research results have reference and guiding significance for the comprehensive evaluation of the suitability of land reclamation as arable land in coal mining areas.
Effects of Acute Heat Stress on Haemato-biochemical Parameters, Oxidative Resistance Ability, and Immune Responses of Hybrid Yellow Catfish (Pelteobagrus Fulvidraco × P. Vachelli) Juveniles
Authors: Dagoudo Missinhoun , Mutebi Ezra Tumukunde , Qiang Jun , Tao Yi-Fan , Zhu Hao-Jun , Ngoepe Tlou Kevin , Xu Pao 
Published: November 2022

Abstract
This study investigated the effect of heat stress on the physiological parameters, oxidation resistance ability and immune responses in juvenile hybrid yellow catfish. Heat stress group exposed to 35°Cand control to 28°C. Blood and liver were sampled at different hours’ post-exposure. Results showed that red blood cell (RBC), white blood cell (WBC) counts, Hemoglobin (HGB) levels and hematocrit (HCT) values increased significantly (P < 0.05) post-exposure to heat stress. This indicates the increase of cell metabolism. Serum alanine aminotransferase (ALT) and aspartate transaminase (AST) activities, total cholesterol (TC), total protein (TP), triglyceride (TG) and glucose increased signiﬁcantly (P < 0.05) indicating the need to cope with stress and cell damage. Liver TC, TG, COR hormone, C3 complement increased significantly from 24h to 96h. Heat stress mostly affects the hepatic antioxidant and immune resistance functions, resulting in increments of cortisol levels, lysozyme, superoxide dismutase (SOD), and catalase (CAT) enzyme activities. The increase of Malondialdehyde (MDA), alkaline phosphatase (AKP) indicate stimulation of the immune responses to protect the liver cells from damage. The decrease in Liver TP indicated liver impairment. Decrease in Glycogen content from 6h to 96h indicated mobilization of more metabolites to cope with increased energy demand. Interestingly, results showed that heat stress trigged costly responses in the experimental fish like accelerated metabolism and deplete energy reserves, which could indirectly aﬀect ability of fish to set up eﬃcient long term defense responses against stress. These results provide insight into prevention and management of stress in juvenile hybrid yellow catfish.