bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of ANGPTL6 With Neonatal Glucose Homeostasis and Fat Mass Is Disrupted in Gestational Diabetic Pregnancies
Authors: Valencia-Martínez Abel , Schaefer-Graf Ute , Amusquivar Encarnación , Herrera Emilio , Ortega-Senovilla Henar 
Published: July 2022

Abstract

Context
Angiopoietin-like protein 6 (ANGPTL6) is a hepatokine, which, in animal studies, improves insulin sensitivity and increases energy expenditure to counteract insulin resistance.

Objective
Evaluate in a human population, the role of serum ANGPTL6 in gestational diabetes mellitus (GDM) or its presence in fetal circulation.

Research design and methods
A total of 190 women (115 controls and 75 GDM) and their offspring were studied. Insulin, glucose, ANGPTL6, retinol binding protein 4 (RBP4), and retinol, as well as leptin and adiponectin, were determined in maternal serum obtained at term and from umbilical artery blood at delivery.

Results
At term, pregnant women with GDM showed higher serum concentrations of ANGPTL6, insulin, homeostatic model assessment, and apo-RBP4 (free RBP4) than controls but not of glucose, which remained similar in both groups. Also, in arterial cord serum, ANGPTL6 concentration was increased in GDM neonates with respect to the control group (201 ± 12 ng/mL vs 119 ± 8 ng/mL, respectively). No effect of maternal insulin treatment of some GDM mothers in neonates of either sex on ANGPTL6 levels was observed. In GDM, circulating ANGPTL6 showed no correlation with glucose or insulin concentration or with neonatal adiposity. However, in control pregnancies, the variation in glucose concentration was positively correlated with ANGPTL6 concentration, both in maternal and in cord samples, and cord ANGPTL6 was negatively correlated with neonatal fat mass. Furthermore, in control pregnant women, serum concentrations of ANGPTL6 and apo-RBP4 were negatively correlated.

Conclusion
Serum ANGPTL6 levels are associated with maternal glucose homeostasis and fetal adiposity in normal pregnancy. ANGPTL6 levels in maternal and cord serum GDM pregnancy at term are increased, although its mechanism and physiological role are unknown yet.
Factors Associated With In-Hospital Post–Cardiac Arrest Survival in a Referral Level Hospital in Uganda
Authors: Alum Rachel Aguma , Kiwanuka Joseph Kyobe , Nakku Doreen , Kakande Elijah Ronald , Nyaiteera Victoria , Ttendo Stephen Senyonjo 
Published: July 2022

BACKGROUND:
Cardiac arrest (CA) is still associated with high mortality and morbidity across all practice settings despite resuscitation attempts and advancements in its management. Patient outcomes vary and are affected by multiple factors. Nonetheless, there is a paucity of information on survival after CA and associated factors in low-resource settings such as East Africa where Uganda is located. This study set out to describe post-CA survival, associated factors, and neurological outcome at a hospital in Southwestern Uganda.

METHODS:
This was a descriptive study in which we followed up with resuscitated CA patients from any of the selected hospital locations at Mbarara Regional Referral Hospital in Southwestern Uganda. We included all patients who were resuscitated after an index CA in the operating room (OR), intensive care unit (ICU), the pediatric ward, or accident and emergency (A&E) wards. Details of resuscitation were obtained from resuscitation team leader interviews and patient medical records. We followed up with patients with return of spontaneous circulation (ROSC) for up to 7 days after CA when neurological outcomes were measured using the age-appropriate Cerebral Performance Category (CPC) score. Factors affecting survival were then determined.

RESULTS:
A total of 74 participants were enrolled over 8 months. Seven-day survival was 14.86%. Eight of the 11 survivors had a CPC score of 1 seven days after CA. Admission with trauma was associated with increased mortality with an adjusted hazard ratio (HR) of 4.06; 95% confidence interval (CI), 1.19–13.82. Compared to the A&E ward, HR for index CA in OR, ICU, and pediatric ward was 0.15; 95% CI, 0.05–0.45; 0.67; 95% CI, 0.32–1.40, and 0.65; 95% CI, 0.25–1.69, respectively. Compared to cardiopulmonary resuscitation (CPR) <10 minutes, the HR for CPR duration between 10 and 20 minutes was 2.26; 95% CI, 0.78–3.24 and for >20 minutes was 2.26; 95% CI, 1.12–4.56. Prevention of hypotension after ROSC was associated with decreased mortality with an HR of 0.23; 95% CI, 0.08–0.58.

CONCLUSIONS:
Whereas 7-day survival of resuscitated CA patients at Mbarara Regional Referral Hospital (MRRH) was low, survivors had a good neurologic outcome. CA in the OR, CPR <20 minutes, and prevention of hypotension postarrest seemed to be associated with survival.
Proton Relay Effects on Oxygen Reduction Reaction Catalyzed by Dinuclear Cobalt Polypyridyl Complexes with OH Groups on Bipyridine Ligands
Authors: Arima Hiroaki , Nakazono Takashi , Wada Tohru 
Published: July 2022

Abstract
Four-electron oxygen reduction reaction (4e−-ORR) is the foundation of both natural and artificial energy conversion systems. Mechanism studies and catalysis improvements of 4e−-ORR are important research for the actualization of a sustainable society. In this study, we present a dinuclear cobalt complex containing mono-deprotonated forms of 6,6′-dihydroxy-2,2′-bipyridine (6DHBP-H+), [Co2(OH)2(6DHBP–H+)2(btpyxa)](PF6)2 (2) is a highly active 4e−-ORR catalyst in a low acid concentration solution. When ferrocene (Fe(Cp)2) was used as a reductant in PhCN containing a low concentration of perchloric acid (1.0 mmol L−1), 2 showed higher selectivity (99%) and reaction rate (kcat = 6.0 × 103 M−1 s−1) for 4e−-ORR than the bpy analog 1 (kcat = 6.2 × 10 M−1 s−1) and 4DHBP analog 3 (kcat = 1.5 × 102 M−1 s−1). A high catalytic current in the cyclic voltammetry (CV) of 2 indicates a high reaction rate for electrochemical ORR under low acid concentration conditions. Moreover, X-ray crystallography of the corresponding monomeric analog [Co(OH2)(6DHBP–2H+)(trpy)](PF6) (4, 6DHBP–2H+: a doubly deprotonated form of 6DHBP) suggests that OH groups of 2 can form hydrogen bonds with a μ-O2 ligand. Hydroxy groups at the 6,6′-position of bpy would deliver protons to the μ-O2 ligand of the intermediate, thereby promoting O–O bond cleavage in the proton-coupled electron transfer (PCET) process.
Laboratory and experimental hut trial evaluation of VECTRON™ T500 for indoor residual spraying (IRS) against insecticide resistant malaria vectors in Burkina Faso
Authors: Bayili Koama , Ki Hyacinthe D. , Bayili Bazoma , Sow Bazoumana , Ouattara Abdoulaye , Small Graham , Hien Aristide S. , Dabire Roch K. , Diabate Abdoulaye 
Published: July 2022

Background: Malaria cases in some areas could be attributed to vector resistant to the insecticide. World Health Organization recommended insecticides for vector control are limited in number. It is essential to find rotational partners for existing Indoor Residual Spraying (IRS) products. VECTRON™ T500 is a novel insecticide with broflanilide as active ingredient. It has a mode of action on mosquitoes completely different to usually used. The aim of this study was to determine the optimum effective dose and efficacy of VECTRONTM T500 against susceptible and resistant strains of Anopheles in Burkina Faso. Methods: VECTRON™T500 was sprayed at 50, 100 and 200 mg/m² doses onto mud and concrete blocks using Potter Spray Tower. The residual activity of broflanilide was assessed through cone bioassays 1 week and then monthly up to 14 months post spraying. Its efficacy was evaluated at 100 and 150 mg/m² against wild free-flying mosquitoes in experimental huts on both substrates. Actellic 300CS was applied at 1000 mg/m² as reference product. Cone assays were conducted monthly, using susceptible and resistant mosquito strains. Results: In the laboratory, VECTRON™ T500 showed residual efficacy (≥80% mortality) on An. gambiae Kisumu up to 12 and 14 months, respectively, on concrete and mud blocks. Similar results were found with 100 and 200 mg/m² using An. coluzzii pyrethroid resistant strain. In experimental huts, a total of 19,552 An. gambiae s.l. were collected. Deterrence, blood-feeding inhibition and exophily with VECTRON™ treated huts were very low. At 100 and 150 mg/m², mortality of wild An. gambiae s.l. ranged between 55% and 73%. Monthly cone bioassay mortality remained >80% up to 9 months. Conclusions: VECTRON™ T500 shows great potential as IRS formulation for malaria vector control. It can be added to the arsenal of IRS products for use in rotations to control malaria and manage mosquito insecticide resistance.
Medical student perceptions of reflective practice in the undergraduate curriculum
Authors: Gishen Faye , Chakrabarti Rima 
Published: July 2022

Introduction: Reflective practice (RP) forms a core component of medical professionalism but, despite its benefits, it remains largely undervalued among medical students. The aim of this study was to explore medical students’ attitudes and barriers to engagement with RP in the undergraduate programme at a UK based medical school. Methods: This was a qualitative study based on the methodology of phenomenology. All penultimate year medical students at University College London Medical School (n=361) were approached for this study and altogether thirteen participants were recruited, with data collected through two focus group discussions. Thematic analysis was used to generate the coding framework. Results: Five key themes emerged around student attitudes to RP, which were grouped into three domains: ‘value of RP’, ‘barriers to engagement’, and ‘strategies for enabling RP’. ‘Value of RP’ centred on the themes of humanising medicine and developing empathy, developing professionalism and RP as a tool for sense-making. ‘Barriers to engagement’ centred on the purpose and tokenism of RP and in the third domain, ‘strategies for enabling RP’, the theme of student agency in RP emerged strongly. Conclusion: Overall, the value of RP was not fully appreciated until students began their clinical placements. Potential strategies identified by participants for optimising engagement included student co-design and positioning RP within a broader pastoral role early in the undergraduate curriculum.
Temporomandibular disorders. Part 4: appliance therapy
Authors: James Martin , Oluwajana Funmi , Foster-Thomas Emma , Crawford Charles , Foster-Thomas Emma , Clarke Peter , Leven A Johanna 
Published: July 2022

Appliances have been used in the management of temporomandibular disorders (TMD) for many years, and over this time designs have waxed and waned in popularity. The majority of appliance designs have few studies to support their use and what evidence is available, is often of low quality. This article, the fourth in a series of six, reviews the mechanisms of action, evidential support for, and provides advice on when to use commonly used appliance designs. CPD/Clinical Relevance: There are a plethora of splint designs in use, but it is essential that the evidence supporting each is understood so that the most appropriate design is used for each individual situation.
Metal–Ceramic implant-supported fixed dental prostheses: the gold standard for the completely edentulous patient. A case report
Authors: Martínez Adel Martínez , Lujan-Pardo María del Pilar , Ariza-Martínez Stephanye 
Published: July 2022

The development of implantology has allowed implant-supported fixed prosthetic treatments in edentulous patients to become the main alternative to conventional rehabilitation. The dental experience of edentate patients comprises an extensive history of successes and failures with traditional rehabilitation. The following report describes a case of a completely edentulous patient who recovered oral function and aesthetics by placing six implants in each jaw and, subsequently, restoration with metal–ceramic implant-supported fixed dental prostheses (FDPs). The authors explore the criteria that must be considered for the selection of the material to be used in implant-supported fixed prostheses. CPD/Clinical Relevance: To ensure enhanced survival rates for implant-supported fixed prosthetic restorations in edentulous patients, patient factors, their expectations, the number of implants to be placed and the materials to be used must be carefully considered.
Investigation of the anisotropy and scaling of the phase structure function of a spatially coherent light beam propagating through convective air turbulence
Authors: Rasouli Saifollah , Mohammadi Razi Ebrahim , Niemela J. J. 
Published: July 2022

We report on applications of moiré deflectometry in measurements of the anisotropy and scaling of the phase structure function (PSF), obtained after passing a laser beam through an indoor enclosure containing convective air turbulence. We combine the use of two telescopes, with a two-channel wavefront sensor based on moiré deflectometry, to attain high sensitivity and resolution to fluctuations in the wavefront phase, caused by turbulent fluctuations in the enclosure. The measurements of the wavefront PSF along two directions perpendicular to the direction of the light beam propagation at different heater temperatures show that the convective air turbulence is anisotropic turbulence, where the value of the anisotropy increases with increasing temperature gradient. Various models are fitted to the measured PSFs, and we find that the turbulent is also non-Kolmogorov, in which, for the separation distances of two points on the wavefront less than 10 cm, the von Kármán PSF is the best fit to the experimental data. For higher values of separations, the experimental data do not fit with existing models. By fitting the von Kármán PSF on the data, we estimate values of the refractive index structure constant,

C
n
2

, as well as the outer scale of the turbulence. The value of the outer scale decreases with increasing temperature of the heater up to approximately 50°C, where it saturates, while the value of

C
n
2

monotonically increases. Over the complete range of heater temperatures, from 40°C to 160°C, the Rayleigh number, Ra, for the enclosed air flow varied from

5.80
×

10
8

<

R
a

<
5.89
×

10
9

so that all measurements were conducted in a state of developed convective turbulence.
Associated factors of the co-occurrence of trachoma and soil-transmitted helminthiases in children 1 to 9 years old in rural communities of the Amazon basin in Loreto Department, Peru: Results from a population-based survey
Authors: Saboyá-Díaz Martha Idalí , Carey Angeles Cristiam Armando , Avellaneda Yajahuanca Rosario del Socorro , Meléndez Ruíz Salvith Karen , Cabrera Rufino , Honorio Morales Harvy Alberto , Pachas Paul E. , Guardo Monica , Renneker Kristen K. , Muñoz Beatriz E. , West Sheila K. 
Published: July 2022

Background
There is evidence of the occurrence of trachoma in Peru, and studies have shown that soil-transmitted helminthiases (STH) are affecting rural communities in the Amazon basin in Loreto Department. This study was done to estimate trachoma prevalence, STH prevalence, and the associated factors for both diseases in children aged 1–9 years in rural communities of Peru.

Methodology
A population-based cross-sectional survey was carried out in rural communities of Loreto. A standardized survey questionnaire with individual and household risk factors related to both diseases was used. Ocular examination was done for all participants aged one year and above, and eye swab samples were collected from children with follicular trachoma (TF). Anthropometric measurements, stool samples for STH, and blood samples for hemoglobin measurement were taken from children.

Principal findings
TF prevalence was 7.74% (95% CI 5.08–11.63%), STH prevalence was 49.49% (95% CI 25.00–52.43%), and prevalence of co-occurrence of both diseases was 5.06% (95% CI 2.80–8.98%) in children aged 1–9 years. Being at age 3–8 years old (AOR = 6.76; 95% CI 1.346–33.947), have an unclean face (AOR = 24.64; 95% CI 6.787–89.444), and having been dewormed in the last six months (AOR = 2.47; 95% CI 1.106–5.514), were risk factors of TF. Being a female (AOR = 0.22; 95% CI 0.103–0.457) was associated with decreased odds of TF. Having been dewormed in the last six months (AOR = 0.30; 95% CI 0.139–0.628) was a preventative factor for STH. Risk factors for children with both diseases mirrored the findings for risk factors for individual diseases.

Conclusions
Neglected tropical diseases and associated risk factors overlap in communities living in vulnerable conditions in the Amazon basin of Peru. These findings support the need to implement integrated interventions, including mass drug administration, water, sanitation, and hygiene for both diseases in the study area.
Use of family history taking for hereditary neoplastic syndromes screening in primary health care: A systematic review protocol
Authors: Pessanha Raphael Manhães , Schuab Sara Isabel Pimentel de Carvalho , Nunes Karolini Zuqui , Lopes-Júnior Luís Carlos 
Published: July 2022

BackgroundAlthough most neoplasms result from complex interactions between the individual’s genome and the environment, a percentage of cases is particularly due to inherited alterations that confer a greater predisposition to the development of tumors. Hereditary Neoplastic Syndromes have a high psychosocial and economic burden, in addition to being characterized by an increased risk for one or more types of cancer, onset of malignancy at a young age, high risk of secondary malignancies, and occurrence in successive generations of the family. Personal and family history, as well as pedigree, may be useful resources to estimate the risk for developing cancer, especially in Primary Health Care settings.ObjectiveTo identify and evaluate the evidence regarding the impact of using family history as a genomic technology for Hereditary Neoplastic Syndromes screening at Primary Health Care.MethodsThis systematic review protocol was elaborated in compliance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P). We will include all observational as well as experimental study designs published up to end of July 2022, and studies covering the impact of family history on screening for Hereditary Neoplastic Syndromes in primary health care. Qualitative studies, as well as guidelines, reviews, and studies undertaken in hospitals, outpatient clinic, or medical environments will be excluded. Five databases will be searched, including MEDLINE/PubMed, Cochrane Library, EMBASE, Web of Science, and LILACS. Additional sources will also be retrieved, including Clinical trials.gov-NIH, The British Library, and Google Scholar. No restriction to language or date will be employed in the search strategy. Three investigators will select studies independently, perform data extraction, and conduct the critical appraisal of the risk of bias and overall quality of the selected studies according to their designs. Regarding data synthesis, the study characteristics will be summarized and presented in tables and results will be presented according to the study design. A qualitative synthesis of data will also be provided in this systematic review.DiscussionTo the best of our knowledge, this systematic review will be the first to identify and critically assess evidence regarding the impact of using family history as a genomic technology for Hereditary Neoplastic Syndromes screening in Primary Health Care settings worldwide. This study is expected to provide consistent evidence that will aid the primary care decision-makers regarding hereditary cancer screening, thus helping individuals and families at risk for cancer.PROSPERO registration numberCRD42020166211.
Glycemic variability and all-cause mortality in a large prospective southern European cohort of patients with differences in glycemic status
Authors: Salinero-Fort Miguel A. , San Andrés-Rebollo F. Javier , Cárdenas-Valladolid Juan , Mostaza José M. , Lahoz Carlos , Rodriguez-Artalejo Fernando , Gómez-Campelo Paloma , Vich-Pérez Pilar , Jiménez-García Rodrigo , López de Andrés Ana , de Miguel-Yanes José M. ,   on behalf the MADIABETES and SPREDIA Consortium
Published: July 2022

Background
Few studies have analyzed the relationship between glucose variability (GV) and adverse health outcomes in patients with differences in glycemic status. The present study tests the hypothesis that GV predicts all-cause mortality regardless of glycemic status after simple adjustment (age and sex) and full adjustment (age, sex, cardiovascular disease, hypertension, use of aspirin, statins, GLP-1 receptor agonists, SGLT-2 inhibitors and DPP-4 inhibitors, baseline FPG and average HbA1c).

Methods
Prospective cohort study with 795 normoglycemic patients, 233 patients with prediabetes, and 4,102 patients with type 2 diabetes. GV was measured using the coefficient of variation of fasting plasma glucose (CV-FPG) over 12 years of follow-up. The outcome measure was all-cause mortality.

Results
A total of 1,223 patients (657 men, 566 women) died after a median of 9.8 years of follow-up, with an all-cause mortality rate of 23.35/1,000 person-years. In prediabetes or T2DM patients, the fourth quartile of CV-FPG exerted a significant effect on all-cause mortality after simple and full adjustment. A sensitivity analysis excluding participants who died during the first year of follow-up revealed the following results for the highest quartile in the fully adjusted model: overall, HR (95%CI) = 1.54 (1.26–1.89); dysglycemia (prediabetes and T2DM), HR = 1.41 (1.15–1.73); T2DM, HR = 1.36 (1.10–1.67).

Conclusion
We found CV-FPG to be useful for measurement of GV. It could also be used for the prognostic stratification of patients with dysglycemia.
Diabetes mellitus and heart failure — a modern look at the mechanisms of development
Authors: Svarovskaya A. V. , Garganeeva A. A. 
Published: July 2022

Heart failure (HF) is a pressing public health problem. According to the literature, the presence of diabetes mellitus (DM) significantly increases the risk of repeated hospitalizations and the length of hospital stay in patients with heart failure. The proportion of HF remains high due to increased life expectancy, higher prevalence of risk factors and improved survival rates. Currently, advances in the treatment of coronary heart disease (CHD) and valvular disease have significantly improved survival rates, but the prognosis for heart failure remains extremely poor. Among the most important medical problems, heart failure occupies a special place in patients with type 2 diabetes. DM contributes to the onset of HF through a variety of mechanisms, including a complex of specific structural, functional, and metabolic changes in the myocardium called diabetic cardiomyopathy. Despite the active study of the causes of cardiomyopathy, the search and implementation of new approaches in assessing the risk of developing this pathological phenomenon in patients with heart failure remains relevant. This review examines current hypotheses for the development of diabetic cardiomyopathy, such as insulin resistance, endothelial dysfunction, fibrosis, lipotoxicity, and energy disorders.