bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Impact of climatic variability of the temperature-humidity index during winter, spring and summer seasons in Egypt on the growth of the native bovine calves
Authors: habeeb alsaied alnaimy , ATTA MOSTAFA ABBAS , SHARAF AHMED KAMEL , Elhanafy Anhar Ibrahim Aly 
Published: February 2022

Abstract
This research aims to check the impact of climatic variability of the THI index during the three main seasons of the year in Egypt on growth traits and biochemical blood components in native bovine calves. Eighteen Egyptian bovine calves after weaning were used in this study. The experimental design included three experimental groups according to the year's seasons. In the 1st group, sex calves were rearing under winter conditions. In the 2nd group, sex calves were kept during the spring season. In the 3rd group, sex calves were maintained during the summer season. Weekly and monthly Temperature-humidity index (THI) was calculated for the three seasons. The daily body gain (DBG) the feed intake (DMI), and water consumption (WC) were measured weekly for each calf. The highest THI value (85.5) during summer resulted in a significant (P<0.01) decrease in DBG, daily DMI, thyroid hormonal levels, total proteins, and glucose and a significant (P<0.01) increase in daily WC and levels of cortisol and urea. The rate of decline increases with increasing THI values from low THI in winter (68.1) to moderate THI during spring (74.9) and high THI (85.5) during the summer season. With increasing THI, the depression in DBG was more than the decline in daily DMI; therefore, food conversion increases when the value of THI increases. THI has highly (P<0.01) significant negative correlations with DBG, DMI, thyroxin (T4), triiodothyronine (T3), total proteins, and glucose and has highly significant (P<0.01) positive correlations with water intake as well as cortisol and urea concentrations.
PIK3CA-AKT pathway predominantly acts in developing ipsilateral breast tumor recurrence long after breast conserving surgery
Authors: Nakagomi Hiroshi , Inoue Masayuki , Hirotsu Yosuke , Amemiya Kenji , Mochiduki Hitoshi , Omata Masao 
Published: February 2022

Abstract
Background: Ipsilateral Breast Tumor Recurrence (IBTR) after breast-conserving therapy is seen after a long interval, but the clinical classification of Residual Tumor Recurrence (RR) or Double Primary (DP) needs to be validated. We used genome profiling to identify the genetic alterations associated with IBTR recurrence after a long period of time. Methods: Among 1,881 breast cancer patients treated with breast-conserving therapy between 1999 and 2018, IBTR occurred in 52 patients (2.8%). Of these, 22 patients who consented for genetic analysis of Primary Breast Cancer (PBC) ( T1) and IBTR (T2) were studied.　 When the same gene mutations in T1 and T2 were identified, it was classified as genomic residual recurrence gRR, and when no shared mutations identified, it was classified as gDP.　The differences between clinical and genomic classification were compared. Furthermore, the pathway of the genes which were responsible for recurrence was also examined. Results: Of 13 clinically diagnosed RRs (cRRs), 11 were gRR and 2 were gDPs, while of 9 cDPs, 6 were gDP and 3 gRR, with a match rate of 17/22 (77%).　Discrepancy was mostly related to the limitation of clinical judgement, heavily depend on tumor location. We searched for genes involved in IBTR: PIK3CA-AKT pathway mutations were found in 12 of 14 gRRs (86%) in T1, while PIK3CA mutations were found in only 2 of 8 gDPs (25%), significant difference was noted (p=0.004). When both of PBC and IBTR compared, PIK3CA-AKT pathway abnormalities were 24/28 (86%) in the gRR group and 5/16 (31%) in the gDP group (p<0.001).Conclusions: Genome profiling revealed that abnormalities in the PIK3CA-AKT pathway in long-term residential recurrences and are a crucial molecular group in the development of IBTR.Trial registration: not applicable
Association between Intraoperative End-Tidal Carbon Dioxide and Postoperative Nausea and Vomiting in Gynecologic Laparoscopic Surgery
Authors: Dong Li , Takeda Chikashi , Yamazaki Hajime , Hamada Miho , Hirotsu Akiko , Yamamoto Yosuke , Mizota Toshiyuki 
Published: February 2022

Abstract
PURPOSE

Gynecologic laparoscopic surgery has a high incidence of postoperative nausea and vomiting (PONV). Studies suggest that low intraoperative end-tidal carbon dioxide (EtCO2) is associated with an increased incidence of PONV, but the results have not been consistent among studies. This study investigated the association between intraoperative EtCO2 and PONV in patients undergoing gynecologic laparoscopic surgeries under general anesthesia.
METHODS

This retrospective cohort study involved patients who underwent gynecologic laparoscopic surgeries under general anesthesia at Kyoto University Hospital. We defined hypocapnia as a mean EtCO2 of <35 mmHg. Multivariable modified Poisson regression analysis examined the association between low EtCO2 and PONV two days after surgery and the postoperative length of hospital stay (PLOS).
RESULTS

Of the 739 patients, 120 (16%) had low EtCO2, and 430 (58%) developed PONV two days after surgery. There was no substantial association between low EtCO2 and increased incidence of PONV (adjusted risk ratio: 0.96; 95% confidence interval [CI]: 0.80–1.14; p = 0.658). Furthermore, there was no substantial association between low EtCO2 and prolonged PLOS (adjusted difference in PLOS: 0.13; 95% CI, −1.00 to 1.28; p = 0.816).
CONCLUSION

Intraoperative low EtCO2 was not substantially associated with either increased incidence of PONV or prolonged PLOS.
Mirror-image Streptavidin with Specific Binding to “Non-natural” L-biotin
Authors: Suganuma Masatoshi , Kubo Takuya , Ishiki Kengo , Tanaka Kota , Suto Kouzou , Ejima Daisuke , Toyota Masahiro , Tsumoto Kouhei , Sato Toshiyuki , Nishikawa Youichi 
Published: February 2022

Abstract
The streptavidin-biotin system is known to have a very high affinity and specificity and is widely used in biochemical immunoassays and diagnostics. However, this method is affected by endogenous D-biotin in serum sample measurements (biotin interference). While several efforts using alternative high-affinity binding systems (e.g., genetically modified streptavidin and biotin derivatives) have been attempted, these efforts have all led to reduction in affinity. To solve this interference issue, the enantiomer of streptavidin was synthesized, which enabled specific binding to L-biotin. We successfully obtained a functional streptavidin molecule by peptide synthesis using D-amino acids and an in vitro refolding technique. Several characterizations, including size exclusion chromatography (SEC), circular dichroism spectra (CD), and heat denaturation experiments collectively confirmed the higher-order enantiomer of natural streptavidin had been formed with comparable stability to the natural protein. Non-natural L-biotin specific binding of this novel molecule enabled us to avoid biotin interference in affinity measurements using the Biacore system and enzyme-linked immunosorbent assay (ELISA). We propose the enantiomer of streptavidin as a potential candidate to replace the natural streptavidin-biotin system, even for in vivo use.
Assessing Splenic Switch-Off In Adenosine Stress CMR For Patients With Atrial Fibrillation: A Propensity Matched Study
Authors: Barrishi Adam , Graby John , Khavandi Ali , Dastidar Amardeep , Rodrigues Jonathan Carl Luis 
Published: February 2022

Abstract
Purpose: Splenic switch-off is a validated indicator of adequate vasodilator stress unique to adenosine stress cardiac magnetic resonance imaging (CMR). Patients in atrial fibrillation (AF) may have a reduced adenosine response due to lower hyperaemic coronary flow reserve, and therefore may achieve splenic switch-off less frequently than in sinus rhythm (SR). Methods: 1100 stress CMR studies were identified from a 5-year clinical CMR database (2016-2021). 70 patients in AF were propensity score matched to a SR group for age, sex, and body mass index. The adenosine dose administered, symptoms, and heart-rate change observed during infusion and scan result were recorded. Splenic switch-off was evaluated subjectively and semi-quantitatively via changes in splenic and myocardial signal intensity from rest to stress. Results: Subjective splenic switch-off occurred significantly less frequently in AF than SR (34/70 [49%] vs 53/70 [76%], p=0.003). Semi-quantitative assessment supported this, with a smaller splenic signal intensity difference between stress and rest in AF vs SR (median splenic stress:rest peak signal intensity ratio 0.92 [IQR, 0.61-1.11] vs 0.56 [IQR, 0.45-0.75], p<0.001). A heart-rate increase >10bpm predicted visual splenic switch-off in SR but not in AF. Fewer patients in AF than SR had inducible ischaemia (9/70 [13%] vs 17/69 [25%], p=0.058). However, this difference was not driven by inducible ischaemia rates in patients who did not achieve splenic switch-off (6/36 AF [17%] vs 4/17 SR [24%], p=0.403).Conclusions: Splenic switch-off occurs significantly less frequently in patients with AF. This may risk the under-diagnosis of inducible ischaemia and requires further assessment.
Impact of Admission SOFA Score and 48-hour Delta Sofa on Clinical Outcomes of Critically Ill Patients
Authors: Vasconcelos Cristiana Soares Queiroz , Cruz Manuel Dominguez de La , Nascimento Gabriel Henrique Lima Barreto do , de Azevedo Jose Raimundo Araujo 
Published: February 2022

Abstract
Background: Multiple organ dysfunction syndrome (MODS) is an important cause of morbidity and mortality in the Intensive Care Unit (ICU). Sequential Organ Failure Assessment (SOFA) scores, determined upon ICU admission, can identify patients at risk of unfavorable outcomes and trigger assessment and application of interventional approaches, of which effectiveness can be evaluated by determining the SOFA score trend after 48 hours. Herein, we evaluated the impact of an admission SOFA score ≥ 2 and the 48-hour delta SOFA, on critically ill patients’ outcomes.Methods: This retrospective, observational cohort study included 1101 patients admitted to three ICUs of a tertiary hospital, from January 01 to December 31, 2020. SOFA scores—determined upon ICU admission and 48 hours thereafter—denoted three patient groups: those with admission SOFA scores below 2 (Group 1, n = 348), those with admission SOFA scores ≥ 2 whose 48-hour delta SOFA reflected improvement (SOFA after 48 hours < admission SOFA) (Group 2, n = 415), and those with admission SOFA scores ≥ 2 that had increased or remained unchanged after 48 hours (SOFA after 48 hours ≥ admission SOFA) (Group 3, n = 338). Statistical tests included the Shapiro-Wilk, Tukey's post hoc, and Kruskal-Wallis tests, among others.Results: Group 1 patients were significantly younger and less severely ill (based on SAPS 3 score and admission SOFA) than those in Groups 2 and 3, and their length of ICU stay was shorter. Furthermore, both their ICU (3.4%) and hospital (8.6%) mortality was significantly lower, compared to that of Group 2 and 3 patients. Among these, patients in Group 3 were older and had significantly higher mortality, both in the ICU (27.3% versus 10.1%, p < 0.001) and hospital (53.8% versus 14.9%, p < 0.001), compared to Group 2 patients. We discovered an independent association between age ≥ 66 years, the Charlson Comorbidity Index, prolonged vasopressor use, and hospital mortality.Conclusion: We demonstrated that the admission SOFA score and 48-hour delta SOFA are predictors of prognosis in a non-selective cohort of critically ill patients.Trial registration: The study protocol was retrospectively registered at ClinicalTrials.gov (NCT04980274, July 27, 2021.)
Exacerbated health related quality of life amid morbidly Obese PCOS women from Faisalabad, Pakistan
Authors: Ahmad Laiq , Ul-Haq Ehsan 
Published: February 2022

Abstract
Background: Projected elevation rate of obesity, as feature of metabolic syndrome (MetS) among PCOS women, more likely intoxicated the women’s health and quality of life (HRQoL). Whereas influence of its multifaceted dysfunctional profile on PCOS pathology can better be explained employing advance statistical approach, structural equation modeling (SEM).Methods: PCOS women with MetS (N=500) were recruited to examine the impact of MetS on association of PCOS manifestation and HRQoL, recorded from normal weight, overweight, obese and morbidly obese women.Results: An appreciable (P<0.05) boost in PCOS and MetS parameters was resulted in obese and morbidly obese women compared to normal weighed. Moreover suggested models for obese women delineated the confounding intricacy of variables from each construct and appropriateness was also ascertained via confirmatory factor analysis (CFA) and goodness of fit statistics (χ2/df=1.68, NFI=0.786, CFI=0.897, RMSEA=0.078). While positive significant (0.523, P=0.001) impact of MetS on PCOS but inverse noticeable (-0.196, P=0.042) effects of PCOS on physical satisfaction was examined in morbidly obese women. A close directional association between physical dissatisfaction and mental distress in women was also revealed.Conclusion: In conclusion, metabolically blemished morbidly obese and obese women were found more threatened by PCOS manifestation as well as impaired HRQoL.
Do Oral Combined Contraceptive Pills Modify Body Image and Sexual Function?
Authors: Nowosielski Krzysztof 
Published: February 2022

Abstract
Background. The effect of hormonal contraceptives on sexual function and body image is still controversial. Existing studies have not come to definite conclusion on the associate between hormonal contraceptive use and sexual function/presence of sexual dysfunction nor changes in body image perception. Thus, this study aimed to evaluate the prevalence of sexual problems/dysfunction in Polish women in the reproductive age (18-45 years) and to assess to what extend oral combined contraceptive pills (OCCP) impact body image, sexual function and prevalence of Female Sexual Dysfunction – FSD. Methods. 495 women were included in this cross-sectional questionnaire-based study. Sexual function was assessed by Changes in Sexual Function Questionnaire - CSFQ, prevalence of FSD by DSM-5 criteria and body image by Body Exposure during Sexual Activity Questionnaire (BESAQ). 237 women using OCCP were study group (HC), the rest were controls (CG). Regression model was used to evaluate the influence of selected variable on sexual function and the presence of FSD. Results. The prevalence of FSD was 7.5% in HC and 2.6% in CG. 22% compared to 14% of women in HC and CG, respectively, reported sexual problems (CSFQ). Contraceptive group was characterized by significantly higher importance of sex (4.03 vs 3.79), worse partner’s’ attitude toward sex (4.35 vs 4.47), worse self-attitude towards sex (4.35 vs 4.47), and worse body image (BESAQ) compared to controls. Among all variables lower level of anxiety (t=-1.99), positive attitudes toward sex (t=2.05), watching erotic videos (t=5.58) and higher importance of sex (t=5.66) were predictive for better sexual function (R2 – 0.38, F=28.9, p=0.0001). Conclusion. Sexual behaviors and function are different in those using OCCP’s compared to non-users. The prevalence of sexual problems and dysfunction is higher in those using hormonal method, however using OCCP is not a risk factor for neither worse sexual function nor sexual dysfunction. Partner’s attitude toward sex and general anxiety level are factors contributing to sexual function and risk of sexual dysfunction in the population of women in reproductive age and should be routinely evaluated in clinical practice, especially before prescribing hormonal contraceptives.
Exploring cocatalyst type effect on the Ziegler-Natta catalyzed ethylene polymerizations: experimental and DFT studies
Authors: Pérez Sergio Posada , Masoori Maryam , Nekoomanesh Mehdi , Rashedi Reza , Bahri Naeimeh 
Published: February 2022

Abstract
Due to the important role of cocatalyst in the polymerization process employing industrially favored Ziegler-Natta catalysts, its effect on kinetic behavior, catalyst activity, and polymer properties is discussed. In this paper triethyl aluminum (TEA) and triisobutyl aluminum (TIBA) have been used as the main cocatalyst ingredient with 10-20 mole percent of diethyl aluminum chloride (DEAC) and ethyl aluminum dichloride (EADC) cocatalysts. Among studied systems, neat TEA demonstrated the highest activity. Moreover, TEA-DEAC and TEA-EADC cocatalysts revealed a built-up kinetic profile, while TIBA-DEAC and TIBA-EADC show a decay-type kinetic curve. According to melt flow index results, no considerable change in flowability was detected in the synthesized polyethylenes (PE). On the other hand, the ethylene insertion and chain termination mechanisms were scrutinized by means of density functional calculations using Ti active center located in (110) and (104) facets of the MgCl2 surface. Results revealed that TiCl4 supported (110) termination favors the PE chain production, being the ethylene insertion, the rate-determining step. To shed light on the bulkiness level of employed cocatalysts, buried volume (VBur) together with the two-dimensional map of cocatalyst molecules were considered. Higher VBur of TIBA can explain its lower activity and decay type kinetic profile obtained in the experimental section.
Adaptive CNC machining process optimization of near- net- shaped blade based on machining error data flow control
Authors: Wu Dongbo , Wang Hui , Yu Jie 
Published: February 2022

Abstract
Adaptive CNC machining process is one of the efficient processing solution for near- net- shaped blade, this study proposes an adaptive computer numerical control (CNC) machining process optimization scheme based on multi-process machining errors data flow control. The geometric and mechanical models of the multi-process adaptive CNC machining process are firstly constructed. The multi-process machining error data flow and the process system stiffness of near- net- shaped blade are then experimentally explored. The machining error flow collaborative control of the near- net- shaped blade multi-process CNC machining is finally realized by the adaptive CNC machining process under the premise of sufficient stiffness of the blade- fixture system. The results show that the dynamic displacement response of the blade multi-process CNC machining process is controlled within 0.007mm. The optimized adaptive CNC machining process based on the multi-process geometric machining error data flow control and the sufficient stiffness of blade- fixture system can realize the multi-process machining error control and high-precision machining of near- net- shaped blade. The process chain of the optimized adaptive CNC machining process is reduced by 87% compared with the low melting point alloy pouring process and 50% compared with adaptive CNC machining process of the twice on-machine measurement on the blade body.
Comparison of Tomography Suspect Keratoconus Defined by Sirius and Pentacam in a Chinese Cohort
Authors: Feng Kang , Zhang Yu , Chen Yue-guo 
Published: February 2022

Abstract
Purpose: To compare the proportion of tomography suspect keratoconus (TSK) defined by Sirius and Pentacam, and to explore the possible causes of the differences between them in a Chinese cohort.Methods: Single center retrospect cohort study. All subjects were selected from the Peking University Third Hospital Ectasia Cornea Disease Cohort Project database, which included myopic patients seeking corneal refractive surgical corrections since the year of 2013. Demographic information, basic eye examination, and auxiliary equipment examination including refraction, IOL-master, Pentacam, Sirius, and Topolyzer were recorded. In this study, all cases which were examined by Sirius and Pentacam respectively and have been followed up at least 2 years without abnormalities after laser corneal refractive surgeries (LASEK, FS-LASIK or SMILE). The composition ratio of TSK from Sirius and Pentacam were compared using Pearson Chi-square tests. Unpaired t tests and Chi-square tests were used to compare the differences of corneal diameter, corneal thickness, and variables of corneal tomographers between the normal eyes and the TSK eyes defined by Sirius and Pentacam separately. Results: To the date of December 31, 2018, total 171 cases (278 eyes) were selected in this study, the mean age is 28.4 years old. Total 167 (167/278, 60.1%) eyes were diagnosed of TSK by Sirius, and 203 (203/278, 73.0%) eyes were diagnosed of TSK by Pentacam (P<0.001). The corneal horizontal diameter is 11.40 and 11.60 mm in normal eyes and Sirius-TSK eyes (P<0.001). The corneal horizontal diameter is 11.74 and 11.43 mm in normal eyes and Pentacam-TSK eyes (P<0.001). The central corneal thickness measured by Sirius is 530.1 μm and 518.1 μm (P=0.001) in normal eyes and Sirius-TSK eyes. The central corneal thickness measured by Pentacam is 521.5 μm and 526.6 μm (P=0.102) in normal eyes and Pentacam-TSK eyes. There is statistical significance between normal eyes and TSK eyes defined by Sirius in the proportion of “yellow or red” SIf and SIb. There is statistical significance between the normal eyes and the TSK eyes defined by Pentacam in the proportion of “yellow or red” Df, Db, Dp, and Da, and there is no difference in Dt between them.Conclusions: The proportion of TSK eyes diagnosed by Sirius is less than those diagnosed by Pentacam in Chinese. Smaller corneal diameter is liable to be judged as TSK by Pentacam in Chinese compared with Sirius. Thinner corneal thickness is liable to be judged as TSK by Sirius in Chinese compared with Pentacam. The variables of SIf and SIb are the main factors leading to TSK in Sirius, the Dt is more stable in Pentacam using for screening normal Chinese cases.
Monitoring and personalization in treatment of breast cancer patients with metastatic bone lesions
Authors: Konovalenko Volodymyr , Drobotun Oleg , Ternovyy Nikolai , Konovalenko Sergii , Garashchenko Oksana 
Published: February 2022

The aim. To increase the efficiency of treatment of BC patients with metastatic lesions of long tubular bones by using, Multidetector computed tomography (MDCT) and bone marrow markers for diagnostics and monitoring the clinical course of the oncologic process, accompanied by surgical intervention with endoprosthetics along with the treatment of polymorbid pathology in a specific patient.
Materials and methods. Authors provide systemic personification including visualization of the tumor site and its vascularization; printing out the 3D model; surgical planning, including optimal surgical access to the tumor site considering the volume and topographic and anatomical location and dissemination of the tumor, the convenience of intraoperative tasks (removal of the tumor, bone grafting or endoprosthetics), preoperative planning of bone resection lines with maximum preservation of intact bone tissue.
Results. Personalization of the treatment of breast cancer patients with metastatic bone lesions contributes to a significant reduction in postoperative complications of endoprosthetic replacement of large joints (up to 15.2 %) and increases the overall three-year survival rate (up to 40.6 %), as well as significantly improves their quality of life.
Conclusions. The personalization of treatment of patients with tumor lesions of the skeletons contributes to a significant decrease in the indicator of postoperative complications of endoprosthetics of great joints and to an increase in the total three-year survival rate, as well as to the improvement of the quality of life after the conducted treatment.