bluuebunny/crossref_metadata_2025_split huggingface dataset:
SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP
Authors: Chen Shuo , Li Qian‐hui , Chen Xi , Bao Hai‐Juan , Wu Wu , Shen Fan , Lu Bing‐Feng , Jiang Ru‐Qi , Zong Zhi‐hong , Zhao Yang 
Published: September 2022

AbstractThe present study demonstrated for the first time that SNORA70E, which belongs to box H/ACA small nucleolar noncoding RNAs (snoRNAs) who could bind and induce pseudouridylation of RNAs, was significantly elevated in ovarian cancer tissues and was an unfavourable prognostic factor of ovarian cancer. The over‐expression of SNORA70E showed increased cell proliferation, invasion and migration in vitro and induced tumour growth in vivo. Further research found that SNORA70E regulates RAS‐Related Protein 1B (RAP1B) mRNA through pseudouracil modification by combing with the pyrimidine synthase Dyskerin Pseudouridine Synthase 1 (DKC1) and increase RAP1B protein level. What's more, the silencing of DKC1/RAP1B in SNORA70E overexpression cells both inhibited cell proliferation, migration and invasion through reducing β‐catenin, PI3K, AKT1, mTOR, and MMP9 protein levels. Besides, RNA‐Seq results revealed that SNORA70E regulates the alternative splicing of PARP‐1 binding protein (PARPBP), leading to the 4th exon‐skipping in PARPBP‐88, forming a new transcript PARPBP‐15, which promoted cell invasion, migration and proliferation. Finally, ASO‐mediated silencing of SNORA70E could inhibit ovarian cancer cell proliferation, invasion, migration ability in vitro and inhibit tumorigenicity in vivo. In conclusion, SNORA70E promotes the occurrence and development of ovarian cancer through pseudouridylation modification of RAP1B and alternative splicing of PARPBP. Our results demonstrated that SNORA70E may be a new diagnostic and therapeutic target for ovarian cancer.
Elevated gamma‐glutamyl transferase to high‐density lipoprotein cholesterol ratio has a non‐linear association with incident diabetes mellitus: A second analysis of a cohort study
Authors: Hu Haofei , Han Yong , Guan Mijie , Wei Ling , Wan Qijun , Hu Yanhua 
Published: September 2022

AbstractObjectiveEvidence regarding the association between the GGT/HDL‐c ratio and incident diabetes is still limited. On that account, our research aims to survey the link of the GGT/HDL‐c ratio with the risk of diabetes.MethodsIn this retrospective cohort study, data of 15,171 participants who participated in the medical examination program were collected in Murakami Memorial Hospital in Japan from 2004 to 2015. The independent and dependent variables were the baseline GGT/HDL‐c ratio and diabetes during the follow‐up, respectively. The Cox proportional‐hazards regression model was used to explore the association between the GGT/HDL‐c ratio and diabetes risk. A Cox proportional hazards regression with the cubic spline smoothing was used to recognize non‐linear relationships between the GGT/HDL‐c ratio and incident diabetes.ResultsAfter adjusting covariates, the results showed that the GGT/HDL‐c ratio was positively associated with incident diabetes (HR = 1.013, 95% CI: 1.002, 1.024). There was also a non‐linear relationship between the GGT/HDL‐c ratio and the risk of diabetes, and the inflection point of the GGT/HDL‐c ratio was 6.477. The HR on the left and right sides of the inflection point was 2.568 (1.157, 5.699) and 1.012 (1.001, 1.023), respectively. The sensitivity analysis demonstrated the robustness of the results. Besides, the performance of the FPG + GGT/HDL‐c ratio was better than FPG + GGT, FPG + HDL‐c, and FPG in predicting diabetes.ConclusionThis study demonstrates a positive and non‐linear relationship between the GGT/HDL‐c ratio and incident diabetes in the Japanese population. The GGT/HDL‐c ratio is strongly related to diabetes risk when it is <6.477.
European guideline (EuroGuiDerm) on atopic eczema – part II: non‐systemic treatments and treatment recommendations for special AE patient populations
Authors: Wollenberg A. , Kinberger M. , Arents B. , Aszodi N. , Avila Valle G. , Barbarot S. , Bieber T. , Brough H.A. , Calzavara Pinton P. , Christen‐Zäch S. , Deleuran M. , Dittmann M. , Dressler C. , Fink‐Wagner A.H. , Fosse N. , Gáspár K. , Gerbens L. , Gieler U. , Girolomoni G. , Gregoriou S. , Mortz C.G. , Nast A. , Nygaard U. , Redding M. , Rehbinder E.M. , Ring J. , Rossi M. , Serra‐Baldrich E. , Simon D. , Szalai Z.Z. , Szepietowski J.C. , Torrelo A. , Werfel T. , Flohr C. 
Published: September 2022

AbstractThe evidence‐ and consensus‐based guideline on atopic eczema was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual. Four consensus conferences were held between December 2020 and July 2021. Twenty‐nine experts (including clinicians and patient representatives) from 12 European countries participated. This second part of the guideline includes recommendations and detailed information on basic therapy with emollients and moisturizers, topical anti‐inflammatory treatment, antimicrobial and antipruritic treatment and UV phototherapy. Furthermore, this part of the guideline covers techniques for avoiding provocation factors, as well as dietary interventions, immunotherapy, complementary medicine and educational interventions for patients with atopic eczema and deals with occupational and psychodermatological aspects of the disease. It also contains guidance on treatment for paediatric and adolescent patients and pregnant or breastfeeding women, as well as considerations for patients who want to have a child. A chapter on the patient perspective is also provided. The first part of the guideline, published separately, contains recommendations and guidance on systemic treatment with conventional immunosuppressive drugs, biologics and janus kinase (JAK) inhibitors, as well as information on the scope and purpose of the guideline, and a section on guideline methodology.
The cost of rate caps: Evidence from Arkansas
Authors: Lukongo Onyumbe Enumbe Ben , Miller Thomas W. 
Published: September 2022

AbstractRegulated small‐dollar installment lenders do not operate within Arkansas, but they do in all six states that border Arkansas. We can measure the effects of Arkansas' 17% interest rate cap because Arkansas residents obtain installment loans only from out‐of‐state lenders. On average, Arkansas residents borrow $1051 at an annual percentage rate of 93%, when incorporating travel costs. Arkansas residents borrow at a rate of 90.4 loans per 10,000 people, compared to 524.5 per 10,000 for residents of the six bordering states. Residents in Arkansas counties that border other states hold 96.7% of out‐of‐state‐supplied small‐dollar installment loans. Statistical tests confirm that the interest rate cap affects residents in the interior counties of Arkansas more than it does residents in the perimeter counties.
Executive networks and global stock liquidity
Authors: Egginton Jared F. , McBrayer Garrett A. , McCumber William R. 
Published: September 2022

AbstractWe examine whether executive networks affect the information environment around stocks in an international setting. We find that firms whose executives are more connected enjoy lower stock liquidity costs, as executive networks lower information asymmetries for market participants. However, the positive effects of executive networks on stock liquidity are subsumed in countries where investor protections are weaker. We empirically separate network effects into an information channel and a power channel, and find that the information channel dominates where institutions foster transparency and accountability. Effects of the power channel are visible where institutions are weak. These results suggest that the detrimental effects of network connections (e.g., managerial entrenchment, extraction of private benefits, propensity to commit fraud) documented in prior studies create space for asymmetric information around stocks when formal institutions are weak. Our results are robust to alternative model specifications and tests for endogeneity.
Should lenders also advise? Evidence from project loans
Authors: Power Gabriel J. , Tandja Djerry C. Mbianda 
Published: September 2022

AbstractBank loans are an important financing component for large‐scale investment projects. To secure loans, firms often enlist the help of a financial advisor (investment bank, boutique firm). Increasingly, large banks offer both advisory and arranging services. This dual role lowers information asymmetry, according to relationship banking, but suggests a potential conflict of interest. We investigate these trade‐offs and their effects for lenders and borrowers. Using a rich database of project‐specific loans and accounting for possible endogeneity, we find that loan spreads, debt levels, and maturities tend to be higher when the arranger also advises. Our results are consistent with relationship banking. Lenders benefit from better information and monopolistic power, whereas borrowers benefit from lower refinancing risk, higher financial flexibility, and a greater likelihood of financing (i.e., greater credit availability).
Effects of technology‐assisted interventions for people with dementia: A systematic review and meta‐analysis
Authors: Saragih Ita Daryanti , Wei Chun‐Wang , Batubara Sakti Oktaria , Saragih Ice Septriani , Lee Bih‐O 
Published: September 2022

AbstractPurposeThe use of technology‐assisted interventions in dementia care contributes to increased communication, reduced burden on the caregivers, improved health outcomes, and improved expense management. Technology‐assisted interventions can be provided remotely to monitor, improve, and enable home care, benefiting the health of both patients and caregivers. Despite increasing use, the effectiveness of technology‐assisted interventions for dementia care remains uncertain, with studies reporting inconclusive findings subject to interpretation. Therefore, the current study investigated the available evidence to explore the efficacy of technology‐assisted interventions for people with dementia.DesignSystematic review and meta‐analysis.MethodsThe study was preregistered with the PROSPERO international prospective register of systematic reviews using a Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA)‐guided protocol. The primary search was conducted in eight databases from database inception to January 29, 2022. Using a random‐effects model, the standardized mean differences (SMDs) with 95% confidence intervals (CIs) were synthesized to obtain pooled effect sizes (using Stata 16.0). The updated Cochrane Risk of Bias 2 tool (RoB‐2) was used to evaluate the methodological quality of the studies.FindingsA pooled analysis of 12 trials, including 584 people with dementia, showed more improvement associated with technology‐assisted interventions compared with standard care, including in the domains of cognitive function (SMD = 0.39; 95% CI: 0.14 to 0.64; p < 0.001) and depression (SMD = −0.75; 95% CI: −1.33 to −0.17; p = 0.01). However, no significant effects were observed for activities of daily living (ADL) or quality of life.ConclusionTechnology‐assisted interventions appear to improve cognitive function and reduce depression in people with dementia compared with standard care.Clinical relevanceThis study may be used to demonstrate that interventions incorporating many modalities or technologies can be used to enhance dementia care, which may improve favorable outcomes when using technology‐assisted interventions to remotely initiate appropriate activities for people with dementia. Because technology allows for simultaneous communication and access to shared multimedia, it removes environmental constraints and allows treatment to be administered remotely.
Integrating morphology and physiology of the key endocrine organ during tadpole development: The interrenal gland
Authors: Regueira Eleonora , O'Donohoe M. E. Ailín , Pavón Novarin Mariela , Michou Etcheverría Gabriela C. , Tropea Carolina , Hermida Gladys N. 
Published: September 2022

AbstractIndirect development is widespread in anurans and is considered an ancestral condition. The metamorphosis of larvae into juveniles involves highly coordinated morphological, physiological, biochemical, and behavioral changes, promoted by the thyroid hormone and interrenal corticosteroids. Stress response to environmental changes is also mediated by corticosteroids, affecting the timing and rate of metamorphosis and leading to great developmental plasticity in tadpoles. Given the potential effect of interrenal gland ontogeny alterations on metamorphosis and the lack of studies addressing both the morphology and endocrinology of this gland in tadpoles, we present corticosterone (CORT) production and histological changes through the ontogeny of interrenal gland in the generalized pond‐type tadpole of Rhinella arenarum (Anura, Bufonidae). This species shows the highest concentration of whole‐body CORT by the early climax when drastic metamorphic changes begin. This is coincident with the morphological differentiation of steroidogenic cells and the formation of interrenal cords. By this stage, steroidogenic cells have a shrunken cytoplasm, with a significantly higher nucleus‐to‐cell diameter ratio. The lowest CORT concentration during premetamorphosis and late climax is associated with small undifferentiated cells with lipid inclusions surrounding large blood vessels between kidneys, and with cords of differentiated steroidogenic cells with a significantly lower nucleus‐to‐cell diameter ratio, respectively. Our study characterizes the morphological and physiological pattern of interrenal gland development, showing an association between certain histological and morphometric characteristics and CORT levels. Variations in this morpho‐physiological pattern should be considered when studying the phenotypic plasticity or variable growth rates of tadpoles.
Nineteen months into the pandemic, what have we learned about COVID‐19‐related outcomes in patients with psoriasis?
Authors: Kridin Khalaf , Schonmann Yochai , Onn Erez , Bitan Dana Tzur , Weinstein Orly , Shavit Eran , Cohen Arnon D. 
Published: September 2022

AbstractBackgroundThe impact of psoriasis on the outcomes of Coronavirus disease 2019 (COVID‐19) is yet to be precisely delineated.ObjectivesTo assess the risk of COVID‐19, COVID‐19‐associated hospitalization, and mortality among patients with psoriasis as compared with age‐, sex‐, and ethnicity‐matched control subjects. In addition, we aim to delineate determinants of COVID‐19‐associated hospitalization and mortality in patients with psoriasis.MethodsA population‐based retrospective cohort study was performed to longitudinally follow patients with psoriasis and their matched controls with regard to COVID‐19‐related outcomes. The risk of COVID‐19 infection, COVID‐19‐associated hospitalization, and mortality were assessed using uni‐ and multi‐variable Cox regression analyses. Determinants of COVID‐19‐associated hospitalization and mortality were evaluated using multivariable logistic regression analysis.ResultsThe study population included 144 304 patients with psoriasis and 144 304 age‐ and sex‐matched control individuals. Patients with psoriasis displayed a slightly elevated risk of SARS‐CoV‐2 infection (fully‐adjusted HR, 1.05; 95% CI, 1.03–1.08; p < 0.001). Relative to controls, patients with psoriasis had comparable multivariate risk of COVID‐19‐associated hospitalization (fully‐adjusted HR, 1.08; 95% CI, 0.99–1.18; p = 0.065) and COVID‐19‐associated mortality (fully‐adjusted HR, 0.88; 95% CI, 0.73–1.05; p = 0.162). When evaluating individuals hospitalized due to COVID‐19, patients with psoriasis were more likely to have type‐2 diabetes mellitus (adjusted OR, 1.24; 95% CI, 1.03–1.50; p = 0.027) and obesity (adjusted OR, 1.37; 95% CI, 1.13–1.65; p = 0.001) relative to controls.ConclusionsWhile patients with psoriasis are at a higher risk of contracting SARS‐CoV‐2 infection, they are not more susceptible to the complications of COVID‐19.
Detection of optrA and poxtA genes in linezolid-resistant Enterococcus isolates from fur animals in China
Authors: Sun W. , Liu H. , Liu J. , Jiang Q. , Pan Y. , Yang Y. , Zhu X. , Ge J. 
Published: September 2022

Abstract
The emergence of linezolid-resistant (LR) enterococci found in food of animal origin arouses attention, but little is known about LR enterococci in fur animals. A total of 342 Enterococcus faecalis and 265 E. faecium strains isolated from fur animals in China from 2015 to 2017 were investigated to determine if LR enterococci (≥16 μg ml−1) are present. Overall, two E. faecalis and 12 E. faecium among these isolates were resistant to linezolid. In addition, all LR isolates were classified as multidrug-resistant isolates. We further explore the resistance genes of the LR enterococci, four E. faecalis and two E. faecium isolates contained optrA gene. Two of them co-harboured optrA and poxtA genes. We detected virulence genes in LR enterococci were the following: asa1, cylA, esp, gelE and hyl, among which the highest carrying rate gene was asa1. Besides, all of the LR enterococci we tested had the biofilm-forming ability. It is worth noting that we detected a novel ST type ST2010 from E. faecium 82-2. These data show LR enterococci exist in fur animals and have unique characteristics.
Population genomics of a predatory mammal reveals patterns of decline and impacts of exposure to toxic toads
Authors: von Takach Brenton , Ranjard Louis , Burridge Christopher P. , Cameron Skye F. , Cremona Teigan , Eldridge Mark D. B. , Fisher Diana O. , Frankenberg Stephen , Hill Brydie M. , Hohnen Rosemary , Jolly Chris J. , Kelly Ella , MacDonald Anna J. , Moussalli Adnan , Ottewell Kym , Phillips Ben L. , Radford Ian J. , Spencer Peter B. S. , Trewella Gavin J. , Umbrello Linette S. , Banks Sam C. 
Published: September 2022

AbstractMammal declines across northern Australia are one of the major biodiversity loss events occurring globally. There has been no regional assessment of the implications of these species declines for genomic diversity. To address this, we conducted a species‐wide assessment of genomic diversity in the northern quoll (Dasyurus hallucatus), an Endangered marsupial carnivore. We used next generation sequencing methods to genotype 10,191 single nucleotide polymorphisms (SNPs) in 352 individuals from across a 3220‐km length of the continent, investigating patterns of population genomic structure and diversity, and identifying loci showing signals of putative selection. We found strong heterogeneity in the distribution of genomic diversity across the continent, characterized by (i) biogeographical barriers driving hierarchical population structure through long‐term isolation, and (ii) severe reductions in diversity resulting from population declines, exacerbated by the spread of introduced toxic cane toads (Rhinella marina). These results warn of a large ongoing loss of genomic diversity and associated adaptive capacity as mammals decline across northern Australia. Encouragingly, populations of the northern quoll established on toad‐free islands by translocations appear to have maintained most of the initial genomic diversity after 16 years. By mapping patterns of genomic diversity within and among populations, and investigating these patterns in the context of population declines, we can provide conservation managers with data critical to informed decision‐making. This includes the identification of populations that are candidates for genetic management, the importance of remnant island and insurance/translocated populations for the conservation of genetic diversity, and the characterization of putative evolutionarily significant units.
Concerns about Lycan's commonsensism
Authors: Bergmann Michael 
Published: September 2022

AbstractDespite wholeheartedly endorsing Lycan's commonsensism on display in On Evidence in Philosophy, this paper raises concerns about three views Lycan defends in that book. The first view is compatibilism about free will and determinism. The paper argues that Lycan's Moorean defense of compatibilism fails and that it is plausible for commonsensists to think that, in their dispute with incompatibilists, the burden of proof is on compatibilists. The second view is Lycan's Principle of Humility, offered as an account of the conditions under which recognized disagreement undermines knowledge. The paper considers a permissive and a demanding way of understanding his Principle of Humility and suggests that, contra Lycan, commonsensism fits better with a permissive understanding. The third view discussed is his coherentism about justification. The paper concludes that commonsensism is best understood in foundationalist terms and that Lycan's coherentism is, in fact, an inadequately motivated version of foundationalism.
Histone‐stimulated platelet adhesion to mouse cremaster venules in vivo is dependent on von Willebrand factor
Authors: Courson Justin A. , Lam Fong W. , Langlois Kimberly W. , Rumbaut Rolando E. 
Published: September 2022

AbstractObjectiveExtracellular histones are known mediators of platelet activation, inflammation, and thrombosis. Von Willebrand Factor (vWF) and Toll‐like receptor 4 (TLR4) have been implicated in pro‐inflammatory and prothrombotic histone responses. The objective of this study was to assess the role of vWF and TLR4 on histone‐induced platelet adhesion in vivo.MethodsIntravital microscopy of the mouse cremaster microcirculation, in the presence of extracellular histones or saline control, was conducted in wild‐type, vWF‐deficient, and TLR4‐deficient mice to assess histone‐mediated platelet adhesion. Platelet counts following extracellular histone exposure were conducted. Platelets were isolated from vWF‐deficient mice and littermates to assess the role of vWF on histone‐induced platelet aggregation.ResultsHistones promoted platelet adhesion to cremaster venules in vivo in wild‐type animals, as well as in TLR4‐deficient mice to a comparable degree. Histones did not lead to increased platelet adhesion in vWF‐deficient mice, in contrast to littermate controls. In all genotypes, histones resulted in thrombocytopenia. Histone‐induced platelet aggregation ex vivo was similar in vWF‐deficient mice and littermate controls.ConclusionsHistone‐induced platelet adhesion to microvessels in vivo is vWF‐dependent and TLR4‐independent. Platelet‐derived vWF was not necessary for histone‐induced platelet aggregation ex vivo. These data are consistent with the notion that endothelial vWF, rather than platelet vWF, mediates histone‐induced platelet adhesion in vivo.
Diversity in new flagellum tip attachment in bloodstream form African trypanosomes
Authors: Smithson Laura , Ihuoma Akazue Pearl , Findlater Lucy , Gwira Theresa Manful , Vaughan Sue , Sunter Jack D. 
Published: September 2022

AbstractThe closely related parasites Trypanosoma brucei, T. congolense, and T. vivax cause neglected tropical diseases collectively known as African Trypanosomiasis. A characteristic feature of bloodstream form T. brucei is the flagellum that is laterally attached to the side of the cell body. During the cell cycle, the new flagellum is formed alongside the old flagellum, with the new flagellum tip embedded within a mobile transmembrane junction called the groove. The molecular composition of the groove is currently unknown, which limits the analysis of this junction and assessment of its conservation in related trypanosomatids. Here, we identified 13 proteins that localize to the flagellar groove through a small‐scale tagging screen. Functional analysis of a subset of these proteins by RNAi and gene deletion revealed three proteins, FCP4/TbKin15, FCP7, and FAZ45, that are involved in new flagellum tip attachment to the groove. Despite possessing orthologues of all 13 groove proteins, T. congolense and T. vivax did not assemble a canonical groove around the new flagellum tip according to 3D electron microscopy. This diversity in new flagellum tip attachment points to the rapid evolution of membrane‐cytoskeleton structures that can occur without large changes in gene complement and likely reflects the niche specialization of each species.