bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Key Genes Involved in Colorectal Cancer: A Bioinformatics Analysis
Authors: Lu Dongxue , Yan Jing , Liu Feng , Zou Kun , Liu Haixia , Zou Wei 
Published: March 2022

Abstract
Background: Colorectal cancer is the life-threatening tumor with the fourth highest incidence and fifth highest mortality worldwide, despite the unknown mechanism behind it.Methods: In this paper, the potential prognostic candidate biomarkers for colorectal cancer were tested by Bioinformatical analysis combined with the CRC clinical samples. It was from the gene expression omnibus (GEO) that three datasets (GSE32323, GSE44076 and GSE43078) were collected. With the limma and clusterProfifiler packages applied, the differentially expressed genes (DEGs) were identified and functional enrichment analysis was conducted. The Search Tool intended for the Retrieval of Interacting Genes (STRING) database was employed to construct a protein–protein interaction (PPI) network, while the module analysis was carried out using Cytoscape. Subsequently, the online tool The Gene Expression Profiling Interactive Analysis (GEPIA; http://gepia.cancer-pku.cn/index.html) was applied to conduct overall survival analysis, while prognostic candidate biomarkers were subject to a further analysis through the Oncomine database. Ultimately, 4 critical hub genes were chosen and validated for their expression among 9 patients with CRC diagnosis by means of reverse transcription-quantitative PCR (RT-qPCR). To evaluate the accuracy of prediction, time-dependent receiver operating characteristic (ROC) was applied. Outcomes: In total, 547 DEGs were identified, inclusive of 475 downregulated and 72 upregulated genes which underwent significant enrichment over the course of cellular response to hypoxia, Positive regulation of ERK1 and ERK2 cascade and Positive regulation of apoptotic process. The major pathways with enrichment were Pathways in cancer,PI3K-Akt signaling pathway,cGMP-PKG signaling pathway. After the extraction of critical modules from the PPI network, 10 hub genes were removed. These 10 hub genes are all up-regulated genes and are highly expressed in colorectal cancer. Survival analysis shows that only CCNB1 and CCNA2 are associated with the survival prognosis of colorectal cancer. Moreover, the expression levels of the 4 hub genes were consistent with the TCGA data sets. Briefly, the new hub genes identified in the present research will contribute to improving our understanding as to the molecular mechanisms of CRC carcinogenesis and progression, thus improving the chance to identify the suitable targets for detecting and treating CRC promptly.
Optimization of damping pad distribution on body-in-white car structure
Authors: Sipos Dávid , Treszkai Marcell Ferenc , Feszty Dániel 
Published: March 2022

Structure-born noise is one of the most important contributors to the interior noise in a vehicle cabin. This can be effectively reduced by placing damping pads with special material properties along the chassis and on the large, radiating panels. This paper proposes a new methodology for the optimization of placing these pads as a part of a full vehicle acoustic simulation in Actran Virtual SEA. With this new strategy, it was possible to reduce the among of damping pads on a real car structure by 33 % while keeping the same acoustic performance. This was validated by investigating the mean velocity of the floor panel in two load cases and compared to the original damping pad layout to the optimized one.
Porcine Epidemic Diarrhea: Causative Agent, Epidemiology, Clinical
Characteristics, and Treatment Strategy Targeting Main Protease
Authors: Shamsi Tooba N. , Yin Jiang , James Michelle E. , James Michael N.G. 
Published: March 2022

Aims:
This aimed to study the causative agent, epidemiology, clinical characteristics, and
treatment strategy targeting the main protease in porcine epidemic diarrhea.

Background:
Porcine epidemic diarrhea (PED) is a contagious intestinal viral infection causing
severe diarrhea, vomiting, and dehydration in pigs. High rates of mortalities and severe morbidities,
approaching 100%, are reported in piglets infected with PEDV. In recent years, PED has been
observed to influence the swine-farming nations in Europe, Asia, the USA, South Korea, and
Canada. The PED virus (PEDV) transmission takes place through a faecal-oral route.

Objective:
The objective is to review the characteristics of PEDV and its role in the disease. In
addition, we aim to outline some possible methods to combat PED infection, including targeting the
main protease of coronavirus and their future perspectives.

Method:
This study is a review of literature on the PED virus.

Results:
Apart from symptomatic treatment and supportive care, there is no available specific
treatment for PEDV. Appropriate disinfectants and cleaning are pivotal for the control of PEDV. To
date, apart from anti-PEDV inhibitors, there are no specific drugs available commercially to treat
the disease. Therefore, 3C-like protease (3CLpro) in PEDV that has highly conserved structure and
catalytic mechanism serves as an alluring drug as it plays a vital role during viral polyprotein
processing at the time of infection.

Conclusion:
A well synchronized and collective effort of scientists, swine veterinarians, pork
industry experts, and associated authorities is essential for the accomplishment of proper execution
of these required measures.
Metal-Organic Framework Based Drug Delivery for Alzheimer's Therapy
and Clinical Progress
Authors: Bukhari Syed Nasir Abbas 
Published: March 2022

Abastract:
Metal-organic frameworks (MOFs) are a category of composite materials synthesized
through metal ions and organic ligands. This class of material has a variety of applications, including
energy storage, isolation, catalysis, sensing, cancer theranostics, and so on; this rapidly expanding
class of frameworks provides advantages. However, MOF uses have not been expanded in chemosensing
and neurodegenerative disease phototherapy. In recent years, there has been a lot of focus on
research on metal-organic structures (MOFs) in biomedical applications. MOFs are considered promising
classes of drug-related nanocarriers based on their well-defined architecture, superficial and porous
surfaces, configurable pores, and simple chemical functionalization. In this report, in the first
part, we explored the special proprieties of MOFs and their benefits for drug delivery as nanocarriers
in biomedical applications. Adapting MOFs to therapeutic agents, like surface adsorption, pore modularity,
covalent bindings, and functional molecules, were also summarized in this review. Many
other MOF applications in chemotherapeutic agents were discovered in the last segment, not only for
a tumor laser treatment but also for neurodegenerative diseases like Alzheimer's (AD). Presently,
highly responsive Alzheimer's biomarkers (AD) are essential for us in preventing and diagnosing
AD, i.e., presenilin 1, amyloid β-protein (Aβ), as well as acetylcholine (ACh). The brain's deviant
amyloid-β peptide (Aβ) mixture is the primary pathologic symptom of Alzheimer's disease (AD). Inhibiting
aggregation is regarded as an appealing preventive action to alleviate amyloid neuroinflammation.
In this study, we looked at how effective response and AD diagnosis have changed, and I
looked at the future of MOFs in this field.
A Platform (Authorships.org) for the Objective Qualification and Order of Academic Authorship in Medical and Science Journals: Development and Evaluation Study Using the Design Science Research Methodology
Authors: Raptis Dimitri Aristotle , Raptis Aristotle , Tinguely Pascale ,   Authorships.org Collaborative
Published: March 2022

Background
The qualification and order of authorship in scientific manuscripts are the main disputes in collaborative research work.

Objective
The aim of this project was to develop an open-access web-based platform for objective decision-making of authorship qualification and order in medical and science journals.

Methods
The design science process methodology was used to develop suitable software for authorship qualification and order. The first part of the software was designed to differentiate between qualification for authorship versus acknowledgment, using items of the recommendations of the International Committee of Medical Journal Editors. The second part addressed the order of authorship, using the analytical hierarchy process for objective multiple criteria decision-making and ranking. The platform was evaluated qualitatively (n=30) and quantitatively (n=18) using a dedicated questionnaire, by an international panel of medical and biomedical professionals and research collaborators worldwide.

Results
Authorships.org represents an open-access software compatible with all major platforms and web browsers. Software usability and output were evaluated and presented for 3 existing clinical and biomedical research studies. All 18 international evaluators felt that the Authorships.org platform was easy to use or remained neutral. Moreover, 59% (n=10) were satisfied with the software output results while the rest were unsure, 59% (n=10) would definitely use it for future projects while 41% (n=7) would consider it, 94% (n=16) felt it may prove useful to eliminate disputes regarding authorship, 82% (n=14) felt that it should become mandatory for manuscript submission to journals, and 53% (n=9) raised concerns regarding the potential unethical use of the software as a tool.

Conclusions
Authorships.org allows transparent evaluation of authorship qualification and order in academic medical and science journals. Objectified proof of authorship contributions may become mandatory during manuscript submission in high-quality academic journals.
Feasibility and Acceptability of a Ugandan Telehealth Engagement Platform for Informational Messaging on Modern Contraception: Pilot Cross-sectional Study
Authors: Kamulegeya Louis Henry , Bwanika JohnMark , Banonya Joy , Atuhaire Joan , Musinguzi Davis , Nakate Vivian , Kyenkya Joshua , Namatende Lydia , Horvath Keith J , Kiragga Agnes 
Published: March 2022

Background
With the region’s highest population growth rate (30%), Uganda is on the brink of a population explosion, yet access to and utilization of public health control measures like modern contraception is a challenge. This is due to remotely located health facilities, noncustomized health content, and poor or nonfunctional post-facility follow-up.

Objective
The aim of our study was to evaluate the feasibility and acceptability of a telehealth engagement platform primarily targeting men; the platform provided behavioral and informational messaging on modern contraception (ie, family planning) and its impact on shaping sexual and reproductive health and knowledge and uptake of family planning services.

Methods
A longitudinal cohort of men aged 18 years and older gave consent to receive mobile phone messages on family planning; follow-up was performed at months 1, 4, and 6 to assess key study-related outcomes on knowledge transfer and acquisition on modern contraception, partner communication, and spousal uptake of family planning. Qualitative interviews with the study participants’ spouses were also performed.

Results
The study included 551 study participants, 450 of whom were men, the primary study participants, who received the family planning mobile messages and 101 of whom were their spouses. Of the 450 primary participants, 426 (95%) successfully received the messages and only 24 (5%) reported not receiving them. The average response (ie, participation) rate in weekly quizzes was 23%. There was a noted 18.1% increase in couple communication attributed to the intervention; couples opened up more to each other on matters concerning family planning.

Conclusions
Using digital channels to address the concerns and inquiries of participants in real time or as fast as possible helped to increase the likelihood that couples adopted family planning.
Challenges in Participant Engagement and Retention Using Mobile Health Apps: Literature Review
Authors: Amagai Saki , Pila Sarah , Kaat Aaron J , Nowinski Cindy J , Gershon Richard C 
Published: March 2022

Background
Mobile health (mHealth) apps are revolutionizing the way clinicians and researchers monitor and manage the health of their participants. However, many studies using mHealth apps are hampered by substantial participant dropout or attrition, which may impact the representativeness of the sample and the effectiveness of the study. Therefore, it is imperative for researchers to understand what makes participants stay with mHealth apps or studies using mHealth apps.

Objective
This study aimed to review the current peer-reviewed research literature to identify the notable factors and strategies used in adult participant engagement and retention.

Methods
We conducted a systematic search of PubMed, MEDLINE, and PsycINFO databases for mHealth studies that evaluated and assessed issues or strategies to improve the engagement and retention of adults from 2015 to 2020. We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Notable themes were identified and narratively compared among different studies. A binomial regression model was generated to examine the factors affecting retention.

Results
Of the 389 identified studies, 62 (15.9%) were included in this review. Overall, most studies were partially successful in maintaining participant engagement. Factors related to particular elements of the app (eg, feedback, appropriate reminders, and in-app support from peers or coaches) and research strategies (eg, compensation and niche samples) that promote retention were identified. Factors that obstructed retention were also identified (eg, lack of support features, technical difficulties, and usefulness of the app). The regression model results showed that a participant is more likely to drop out than to be retained.

Conclusions
Retaining participants is an omnipresent challenge in mHealth studies. The insights from this review can help inform future studies about the factors and strategies to improve participant retention.
A perspectiva de gênero em Ciência, Tecnologia e Inovação no Sul Global: uma análise da FAPESP
Authors: Ferreira Gabriela Gomes Coelho , Onuki Janina 
Published: March 2022

Este artigo tem como objetivo discutir a questão de gênero na FAPESP por intermédio de dois indicadores: os cargos de tomada de decisão e os acordos internacionais assinados com a União Europeia, e seus países membros e associados. A análise faz uso de fontes primárias: a partir dos dados oficiais da Fundação, utiliza estatística descritiva para verificar a porcentagem de mulheres em cargos de tomada de decisão por áreas do conhecimento, quando possível; assim como analisa acordos internacionais para verificar a menção à igualdade de gênero em seus textos. Apenas 8% do Conselho Superior, em uma perspectiva histórica, foi composto por mulheres. Além disso, apenas 2% dos acordos analisados citavam a igualdade de gênero. Na FAPESP, apesar de ser possível observar um aumento histórico da participação das mulheres, o resultado da análise mostra que ainda há muito o que avançar quanto à assimetria nas carreiras científicas, assim como em níveis hierárquicos mais altos relacionados à política científica. Neste cenário, a criação de políticas científicas e tecnológicas com a finalidade de desenvolver incentivos para a igualdade de gênero é essencial.
Sobrevida en pacientes con cirrosis de acuerdo con su etiología. Cohorte retrospectiva
Authors: Prieto-Ortiz Jhon Edison , Garzón Orjuela Nathaly , Sánchez-Pardo Santiago , Prieto-Ortíz Robin Germán , Eslava Schmalbach Javier 
Published: March 2022

Introducción: la cirrosis es el estadio final de enfermedades hepáticas crónicamente progresivas de diferentes etiologías. Es una enfermedad frecuente, con una prevalencia variable en cada país. Su pico de incidencia se presenta entre los 40 y 50 años, predominantemente en hombres.
Objetivos: comparar una cohorte de pacientes con diagnóstico de cirrosis, evaluar sus complicaciones y sobrevida de acuerdo con su etiología, describir los aspectos clínicos y de laboratorio, y determinar el papel del hígado graso.
Materiales y métodos: se realizó un estudio de cohorte retrospectiva, en donde se incluyeron pacientes que asistieron a consulta especializada de hepatología en el centro de enfermedades hepáticas y digestivas (CEHYD), en la ciudad de Bogotá, durante enero de 2010 y junio de 2019.
Resultados: se revisaron un total de 1200 historias clínicas (56,8 % mujeres). No se evidenció diferencias estadísticamente significativas en las medianas de sobrevida entre los grupos por etiologías, sexo, presencia o no de complicaciones, o Child. Se evidenció que entre mayor edad en el diagnóstico de cirrosis, el riesgo de muerte es mayor; HR 1,04 (IC 95 % 1,02-1,075). Por cada mes que aumenta el seguimiento se reduce el riesgo de muerte en 90 %; HR 0,1 (IC 95 % 0,03-0,29). Por cada mes que aumenta el seguimiento de las complicaciones se reduce el riesgo de muerte en 2 %; HR 0,98 (IC 95 % 0,97-0,99).
Conclusiones: La sobrevida por etiología fue similar en los diferentes grupos. La esteatohepatitis no alcohólica (NASH) fue la principal causa de cirrosis en esta cohorte. Se deben orientar esfuerzos a su diagnóstico y manejo en fases tempranas.
Manejo quirúrgico de la necrosis pancreática infectada. Serie de casos en un hospital de cuarto nivel en Bogotá, Colombia, 2014-2021
Authors: Rey Chaves Carlos Eduardo , Ricaurte Alberto , Gómez Monica , Gonzalez Pablo , Castillo Felipe 
Published: March 2022

Introducción: la pancreatitis es una patología frecuente en nuestro medio, mayormente relacionada con la patología biliar benigna. Esta puede progresar a formas severas en 10 %-15 % de los casos, en donde el tejido pancreático se necrosa y forma grandes colecciones, con riesgo de infección. En Colombia no conocemos los datos epidemiológicos acerca de la incidencia de este tipo de complicaciones, ni del manejo de las mismas.
Objetivo: este estudio tiene como objetivo estudiar la prevalencia de la necrosis pancreática infectada y describir los casos identificados en un hospital de alto nivel de complejidad entre 2014 y 2021.
Métodos: estudio observacional de corte transversal. Se analizaron los registros de pacientes diagnosticados con pancreatitis en segunda etapa. Se estudiaron aquellos casos que presentaron necrosis pancreática infectada y se sometieron a desbridamiento más drenaje quirúrgico por vía laparoscópica y abierta en el Hospital Universitario Mayor Méderi de Bogotá, Colombia, entre enero de 2014 y enero de 2021. Se realizó un muestreo por conveniencia, sin cálculo de tamaño de muestra. Se recolectaron variables demográficas y clínicas de los pacientes. Se realizó un análisis estadístico descriptivo de las variables obtenidas en Excel. Las variables cualitativas se describieron a través de frecuencias absolutas y relativas; mientras que las cuantitativas se expresaron mediante medidas de tendencia central y de dispersión en función de su distribución.
Resultados: se analizaron 1020 episodios de pancreatitis y se evidenció necrosis pancreática en 30 pacientes, es decir, una prevalencia de período de 2,9 %. De los pacientes, 83 % (n = 25) se llevó a drenajes por vía abierta, con un 48 % (n = 12) de mortalidad. En relación con el manejo por vía laparoscópica, la reducción en la falla orgánica posoperatoria fue de 40 % (n = 2), con un 30 % menos de duración en la estancia hospitalaria, comparado con la vía abierta. Aquellos pacientes que presentaron un nivel de procalcitonina (PCT) menor de 1,8 ng/mL tuvieron menos mortalidad.
Conclusiones: el abordaje laparoscópico muestra resultados prometedores en cuanto a la morbilidad y mortalidad final observada.
Water for Domestic Animal Drinking Based on the Categorization of Species in an Urban Brazilian Slum
Authors: Da Silva José Natanael Tavares , Bezerra Sabrina Rafael , Vasconcelos Ulrich 
Published: March 2022

Every animal needs safe water for drinking. The quality of this water is essential for welfare. This study discusses on the quality of water furnished to about 50 domestic animals based on the categorization of species practiced by residents at São Rafael slum, located in the city of João Pessoa, Brazil. The drinking water comes from three sources: municipal supply system, bottled mineral water and directly from the Jaguaribe River. The water perceived as safest was the same as offered to pets. Domestic animal water samples were tested and rated as not recommended in more than 65% of the samples. The density of thermotolerant coliforms ranged between 0 and 11,000 cells/100 mL. One third of the samples considered unsuitable for animal watering were also outside the recommended pH. In addition, a differential behavior was observed in the choice of water source according to the caretaker's perception of safety. Dogs and cats, considered family members, received the same water as consumed by the family. Even these, 38.5% of the samples, were rated as not recommended and represented a risk to the health of all those who consumed it. As well, a need for good practices of hygiene in water management and cleaning of water dishes, tanks and troughs was seen.
Gender Analysis of Labor Contribution Among Maize Farming Household in Agricultural Zone C of Kogi State, Nigeria
Authors: Hauwa Bako , Umar Haruna S. , Salau Emmanuel S. , Shehu Ibrahim , Bako Sani 
Published: March 2022

This study analysed the gender labour contribution among maize farming households in Agricultural Zone C of Kogi State, Nigeria. A multi-stage sampling technique was used to select 160 households from which the males and females were interviewed. Data collected were analysed using descriptive statistics. The mean age of male respondents was 40 years while that of female respondents was 33 years. Average income of male farmers was ₦147,321.9 while that of female farmers was ₦143,475.0. The average household size of the respondents was 8 persons. Male respondents were more dominant in tertiary education than female respondents. The result on labour contributions reveals Men dominated in all the maize production activities except planting/sowing where women provided 72.1% of the labour. In extreme instances such as harvesting men provided 100% of the labour needed. Land preparation had 66.5% contribution from the male respondents while the females offered only 33.5%. Male contribution in tilling was 78.8% to the female 21.2%. In making ridges men provided 71.3% against the female 28.7%. In planting/sowing, the only activity women had dominance in, women were seen to have provided 72.1% of the labour contribution against 27.9% of the labour male respondents provided. Furthermore, 70.7% of the labour provided for weeding came from the male folks while the females provided 29.3% of the labour. Male respondents provided 89.9% of the labour for fertilizer application as against the 10.1% provided by the female respondents. Pesticide application was 73.8% of the male against 26.2% of labour contribution. Transportation saw men provide 98.5% of the labour against the 1.5% provided by the female. The results on constraints revealed that poor access to farm inputs was 91.3% for male, while that of female was 96.3, poor transport systems were 88.1% for both male and female, lack of storage/processing facilities was 86.3% for both male and female and poor access to credit was 95.0% while the female was 97.5%. It can be concluded that male gender in the household dominated the female gender in terms of labour contribution in the study area. Most constraints identified bother around institutional and infrastructural inadequacies in Nigeria’s rurality therefore there should be provision of better extension service, access to credit facilities and motorable roads in rural areas in study area.