bluuebunny/crossref_metadata_2025_split huggingface dataset:
WASP-193b: An extremely low-density super-Neptune
Authors: Barkaoui Khalid , Pozuelos Francisco , Hellier Coel , Smalley Barry , Nielsen Louise D. , Dorn Caroline , Gillon Michaël , Helled Ravit , Müller Simon , Jehin Emmanuel , Demory Brice-Olivier , Niraula Prajwal , Soubkiou Abderahmane , Ghachoui Mourad , Anderson David. R. , Benkhaldoun Zouhair , Bouchy Francois , Burdanov Artem , de Wit Julien , Delrez Laetitia , Ducrot Elsa , Garcia Lionel , Jabiri Abdelhadi , Lendl Monika , Maxted Pierre , Murray Catriona , Pedersen Peter , Queloz Didier , Sebastian Daniel , Turner Oliver , Udry Stéphane , Timmermans Mathilde , Triaud Amaury , West Richard 
Published: March 2022

Abstract

Gas giants transiting bright nearby stars are key objects for our understanding of planetary system formation and evolution mechanisms. This paper presents a new transiting exoplanet discovered by the WASP-South transit survey, WASP-193b. WASP-193b orbits its Vmag = 12.0 F9 main-sequence host star every 6.25d. Our analyses found that WASP-193b has a mass of Mp = 0.146 ± 0.033 M_Jup, a radius of R_p = 1.58 ± 0.14R_Jup, translating into an extremely low density of rho_p = 0.049 ± 0.015g/cm3. The planet was confirmed photometrically by the 0.6-m TRAPPIST-South and 1.0-m SPECULOOS-South telescopes and spectroscopically by the ESO-3.6-m/HARPS and Euler-1.2-m/CORALIE spectrographs. The combination of its large transit depth (dF≈1.4%), its super-low density, its high-equilibrium temperature (T_eq = 1275 ± 40K), and the infrared brightness of its host star (magnitude Kmag=10.7) makes WASP-193b an exquisite target for a detailed atmospheric characterization by transmission spectroscopy.
Evaluation and projections of the East Asian summer monsoon in a perturbed parameter ensemble
Authors: Rostron John W. , Sexton David M. H. , Furtado Kalli , Carvalho Maria João , Milton Sean F. , Rodríguez José M. , Zhang Wenxia 
Published: March 2022

Abstract
The East Asian summer monsoon (EASM) is a dominant driver of East Asian climate, with variations in its strength potentially impacting the livelihoods of millions of people. Understanding, predicting and assessing uncertainties in these variations is therefore an important area of research. Here, we present a study of the projected 21st Century changes in the EASM using a ‘perturbed parameter ensemble’ (PPE) of HadGEM3-GC3.05 coupled climate models, which samples uncertainties arising from differences in model parameter values. We show that while the present-day performance of PPE members for leading order EASM metrics is comparable to CMIP5 models in many respects, the PPE also exposes model biases which exist for most, if not all, parameter combinations. These ‘structural’ model biases are found mainly in the low-level circulation over the South China Sea and west Pacific. We also show that future changes in regional circulation and precipitation are projected consistently across the PPE members. A more detailed moisture budget analysis of the precipitation changes in a region covering the Yangtze River valley shows that both dynamic and thermodynamic changes contribute to an increase in precipitation over the 21st century, but that the spread in this response across the PPE is mainly due to spread in the dynamic responses. We also discuss how the information provided by the PPE may be used in practice, considering the plausibility of the models, and giving examples of ways to sub-select ensemble members to capture the diversity in the moisture budget changes.
Cardiovascular Particularities in Pega Breed Donkeys (Equus asinus)
Authors: Aleixo Amanda Sarita Cruz , de Oliveira Karina Cristina , Ferreira Lucas Vinícius de Oliveira , Quevedo Dario Alejandro Cedeño , Tsunemi Miriam Harumi , Chiacchio Simone Biagio , Lourenço Maria Lucia Gomes 
Published: March 2022

Abstract
Clinical, electrocardiographic and echocardiographic parameters in Pega donkeys are scarce in literature, hence this study was performed to evaluate the effect of sex and age on echocardiographic and electrocardiographic measurements in the Pega breed donkeys. The objectives of this study were to describe and illustrate the clinical, electrocardiographic and echocardiographic parameters in Pega donkeys. Fifty Pega breed donkeys were evaluated, with an average age of 3.4 years, 20 males and 30 females. Based on their age (younger or older than 6 years), animals were separated into two groups. In each animal the electrocardiographic examination was performed using the TEB® computerized system and the echocardiographic examination was performed using an ultrasound device with a doppler function multifrequency sectorial transducer, in 2D mode. Male echocardiographic measurements were significantly higher than females, except the velocity and pressure gradient of the pulmonary flow, where females had higher values than males. For the electrocardiographic parameters, females presented values of P wave amplitude, R wave amplitude, S wave amplitude and T wave amplitude higher than those found in males. Males had higher values for P wave duration, QRS complex and RR interval. Standardizing the electrocardiographic and echocardiographic parameters for the Pega breed donkey can contribute to future assessments regarding possible changes that excessive effort can promote in these parameters, to a management engrossed on animal welfare. Furthermore, as well as in other species, gender in donkeys should be considered as a factor that influences echocardiographic and electrocardiographic parameters.
The Factors and Outcomes of Stigma Toward Mental Disorders in Medical Students: A Cross-Sectional Study
Authors: Meng Na , Huang Xia , Wang Jingjun , Wang Mengmeng , Wang Ya 
Published: March 2022

Abstract
Background
Medical students’ attitudes toward mental disorders have a large impact on patients’ health outcomes. However, there are few studies about stigma toward mental disorders in medical students in China.
Methods
In this cross-sectional study, 838 medical students completed questionnaires on their sociodemographic characteristics and familiarity with people diagnosed with mental disorders as well as the Community Attitudes toward Mental Illness Scale (CAMI). A multiple logistic regression model was built to explore the relationships among sociodemographic characteristics, familiarity with mental disorders and stigma.
Results
The total mean score of the CAMI was 137.61 (SD = 15.63). The score for authoritarianism (M = 33.33, SD = 3.62) was the lowest score of the four subscales. Stigma was significantly associated with students’ education, area of residence, marital status, economic status, history of mental disorders and contact with people diagnosed with mental disorders.
Conclusions
Medical students show a negative attitude toward mental illness to a certain degree, especially regarding the view that people with mental disorders are inferior. Higher education level, residence in urban areas, single marital status, better economic status, and better familiarity with mental disorders may be related to less stigma in medical students.
Control of Line Complications With KiteLock (CLiCK) in the Critical Care Unit: Study Protocol for a Multi-center, Cluster-randomized, Double-blinded, Crossover Trial Investigating the Effect of a Novel Locking Fluid on Central Line Complications in the Critical Care Population.
Authors: Ornowska Marlena , Wong Hubert , Ouyang Yongdong , Mitra Anish , White Aaron , Willems Sue , Wittmann Jessica , Reynolds Steven 
Published: March 2022

Abstract
• Background: Insertion of a central venous access device (CVAD) allows clinicians to easily access the circulation of a patient to administer life-saving interventions. Due to their invasive nature, CVADs are prone to complications such as bacterial biofilm production and colonization, catheter-related bloodstream infection, occlusion, and catheter-related venous thrombosis. A CVAD is among the most common interventions for patients in the Intensive Care Unit (ICU), exposing this vulnerable population to risk of nosocomial infection and catheter occlusion. Current standard of care involves use of normal saline as a catheter locking solution for central venous catheters (CVCs) and peripherally inserted central catheter (PICC) lines, and a citrate lock for hemodialysis catheters. Saline offers little prophylactic measures against catheter complications. 4% tetrasodium Ethylenediaminetetraacetic acid (EDTA) fluid (marketed as KiteLock Sterile Locking Solution™) is non-antibiotic, and possesses antimicrobial, anti-biofilm, and anti-coagulant properties and is approved by Health Canada as a catheter locking solution. As such, it may be a superior CVAD locking solution than the present standard of care lock in the ICU patient population. • Methods: Our team proposes to fill this knowledge gap by performing a multi-center, cluster-randomized, crossover trial evaluating the impact of 4% tetrasodium EDTA on a primary composite outcome of incidence rate of central-line associated bloodstream infection (CLABSI), catheter occlusion leading to removal, and use of alteplase to resolve catheter occlusion compared to the standard of care. The study will be performed at six critical care units.• Discussion:If successful, results of this study can serve as evidence for a shift of standard of care practices to include EDTA locking fluid in routine CVAD locking procedures. Completion of this study has the potential to improve CVAD standard of care to become safer for patients, as well as provides an opportunity to decrease strain on healthcare budgets related to treating preventable CVAD complications. Success and subsequent implementation of this intervention in the ICU may also be extrapolated to other patient populations with heavy CVAD use including hemodialysis, oncology, parenteral nutrition, and pediatric patient populations. On a global scale, eradicating biofilm produced by antibiotic-resistant bacteria may serve to lessen the threat of ‘superbugs’ and contribute to international initiatives supporting termination of antibiotic overuse.• Trial registration: This trial is registered with the ClinicalTrials.gov Protocol Registration and Results System as NCT04548713.
A comparative analysis of experienced uncertainties in relation to Risk Communication during COVID19. A four-country study
Authors: Cristea Florin , Weishaar Heide , Geurts Brogan , Delamou Alexandre , Tan Melisa Mei Jin , Legido-Quigley Helena , Aminu Kafayat , Mari-Sáez Almudena , Rocha Carlos , Camara Bienvenu , Barry Lansana , Thea Paul , Boucsein Johannes , Bahr Thurid , Al-Awlaqi Sameh , Pozo-Martin Francisco , Boklage Evgeniya , Jegede Ayodele Samuel , Bcheraoui Charbel El 
Published: March 2022

Abstract
Background
During outbreaks, uncertainties experienced by affected communities can influence their compliance to government guidance on public health. Communicators and authorities are, hence, encouraged to acknowledge and address such uncertainties. However, in the midst of public health crises, it can become difficult to define and identify uncertainties that are most relevant to address. We analyzed data on COVID-19-related uncertainties from four socio-economic contexts to explore how uncertainties can influence people’s perception of, and response to Risk Communication and Community Engagement (RCCE) strategies.
Results
This qualitative study, which adopts an interpretative approach, is based on data from a documentary review, key informant interviews (KII), and focus group discussions (FGD) with members of the general public and people with barriers to information from Germany, Guinea, Nigeria, and Singapore. Transcripts from the KII and FGD were coded and analyzed thematically. We interviewed a total of 155 KIs and conducted 73 FGD. Our analysis uncovered a divergence between uncertainties deemed relevant by stakeholders involved in policy making and uncertainties that people reportedly had to navigate in their everyday lives and which they considered relevant during the pandemic. We identified four types of uncertainties that seemed to have influenced people’s assessment of the disease risk and their trust in the pandemic control strategies including RCCE efforts: epidemiological uncertainties (related to the nature and severity of the virus), information uncertainties (related to access to reliable information), social uncertainties (related to social behavior in times of heightened risk), and economic uncertainties (related to financial insecurities).
Conclusion
We suggest that in future outbreaks, communicators and policy makers could improve the way in which affected communities assess their risk, and increase the trust of these communities in response efforts by addressing non-epidemiological uncertainties in RCCE strategies.
Response of nonconforming RC shear walls with smooth bars under quasi-static cyclic loading
Authors: Olabi M. Nadir , Çaglar Naci , Arslan Mehmet Emin , Ozturk Hakan , Demir Aydin , Dok Gokhan , Aykanat Batuhan 
Published: March 2022

Abstract
In this study, an experimental investigation is conducted to determine the behavior of RC shear walls found in old and existing buildings that do not comply with the design rules in modern earthquake standards. Scaled reinforced concrete shear wall specimens are built with smooth bars and low concrete quality. The dimensions of the shear wall specimens were selected with an aspect ratio bigger than two as 2500, 1050, and 150 mm for the height, length, and thickness, respectively. Four specimens are representative of nonconforming shear walls, and one wall used as a reference specimen which was designed in accordance with recent building codes using deformed bars. The behavior of the shear walls is determined experimentally by displacement-lateral load relationship under lateral cyclic loading. The study used measurable parameters to investigate the behavior of the test specimens in terms of lateral force capacity, rigidity, ductility, dissipated energy, and displacement components contribution to the total lateral response of the walls. The results showed a substantial loss of stiffness, ductility and energy dissipation capabilities for the tested nonconforming shear walls. Moreover, it is proven in this study that these specimens are governed by the bar slip phenomena which demonstrated more than 80% contribution to the total lateral displacement capacity. In contrast, the reference shear wall exhibited a notable flexural behavior and plastic hinge formation. Additionally, the shear walls built with smooth reinforcement bars lost about 44% of their theoretical potential flexural capacity due to the observed bar slip failure.
Circulating microRNA-122 as a potential biomarker for Hepatitis C Virus-Induced Hepatocellular Carcinoma
Authors: Malik Abdul , Barooah Prajjalendra , Saikia Snigdha , Kalita Simanta , Kalita Manash Jyoti , Das Partha Pratim , Bharali Pooja , Sarma Manash Pratim , Sarmah Preeti , Bhattacharyya Mallika , Kar Premashish , Goswami Bhabadev , Medhi Subhash , Alkholief Musaed , Alshamsan Aws 
Published: March 2022

Abstract
The features of translational repression by micro-RNA can cause various diseases in humans. The liver-specific microRNA (mir122) is primarily involved in tissue tropism during HCV infection. This study focuses on evaluating host serum miR-122 as a prognostic marker in HCV infection. A positive expression of miR-122 was observed in CHC patients followed by HCC patients compared to healthy controls. A difference in median levels of miR-122 expression in CHC and HCC patients (p < 0.000) was found in contrast to Cirrhosis patients (p = 0.511). The serum miR-122 expression was found threefold higher in liver cirrhosis patients than chronic hepatitis. Further, the AUROC analysis of miR-122 expression profile can efficiently distinguish CHC patients (AUROC = 0.978, p = 0.000, 95% CI = 0.958 to 0.998) and HCC from healthy controls (AUROC = 0.971, p = 0.000, 95% CI = 0.944 to 0.997). Moreover, ROC curve analysis significantly distinguished between CHC patients from Cirrhosis patients (AUROC = 0.955, p = 0.000, 95% CI = 0.925 to 0.986) but not CHC from HCC patients (AUROC = 0.584, p = 0.104, 95% CI = 0.485 to 0.684). This study revealed a substantial correlation of miR-122 with HCV viral load (r = 0.56, p = 0.000), ALT (r = 0.67, p = 0.000) and AST (r = 0.65, p = 0.000) levels. Serum miR-122 can potentially serve as a promising prognostic tool for HCV induced HCC.
Polyphenic Risk Score Shows Robust Predictive Ability For Long-Term Future Suicidality
Authors: Cheng Mingxi , Roseberry Kyle , Choi Yena , Quast Laura , Gaines Madelaine , Sandusky George , Kline Jeffrey , Bogdan Paul , Niculescu Alexander B. 
Published: March 2022

Abstract
Suicides are preventable tragedies, if risk factors are tracked and mitigated. We had previously developed a new quantitative suicidality risk assessment instrument (Convergent Functional Information for Suicidality, CFI-S), which is in essence a simple polyphenic risk score, and deployed it in a busy urban Emergency Department, in a naturalistic cohort of consecutive patients. We report a four years follow-up of that population (n = 482). Overall, the single administration of the CFI-S was significantly predictive of suicidality over the ensuing 4 years (occurrence- ROC AUC 80%, severity- Pearson correlation 0.44, imminence-Cox regression Hazard Ratio 1.33). The best predictive single phenes (phenotypic items) were feeling useless (not needed), a past history of suicidality, and social isolation. We next used machine learning approaches to enhance the predictive ability of CFI-S. We divided the population into a discovery cohort (n=255) and testing cohort (n=227), and developed a deep neural network algorithm that showed increased accuracy for predicting risk of future suicidality (increasing the ROC AUC from 80% to 90%), as well as a similarity network classifier for visualizing patient’s risk. We propose that the widespread use of CFI-S for screening purposes, with or without machine learning enhancements, can boost suicidality prevention efforts. This study also identified as top risk factors for suicidality addressable social determinants.
Effect of Erythromycin on Mortality and the Host Response in Critically Ill Patients With Sepsis: a Target Trial Emulation
Authors: Reijnders Tom D.Y. , Peters-Sengers Hessel , Vught Lonneke A. van , Uhel Fabrice , Bonten Marc J.M. , Cremer Olaf L. , Schultz Marcus J. , Stuiver Martijn M. , Poll Tom van der 
Published: March 2022

Abstract
Background: Immunomodulatory therapies that improve the outcome of sepsis are not available. We sought to determine whether treatment of critically ill patients with sepsis with low-dose erythromycin – a macrolide antibiotic with broad immunomodulatory effects – decreased mortality and ameliorated underlying disease pathophysiology.Methods: We conducted a target trial emulation, comparing patients with sepsis admitted to two intensive care units (ICU) in the Netherlands for at least 72 hours, who were either exposed or not exposed during this period to treatment with low-dose erythromycin (up to 600 mg per day, administered as a prokinetic agent) but no other macrolides. We used two common propensity score methods (matching and inverse probability of treatment weighting) to deal with confounding by indication, and subsequently used Cox regression models to estimate the treatment effect on the primary outcome of mortality rate up to day 90. Secondary clinical outcomes included change in SOFA, duration of mechanical ventilation, and the incidence of ICU-acquired infections. We used linear mixed models to assess differences in 15 host response biomarkers reflective of key pathophysiological processes from admission to day 4. Results: 235 patients started low-dose erythromycin treatment, 470 patients served as controls. Treatment started at a median of 38 [IQR 25-52] hours after ICU admission for a median of 5 [IQR 3-8] total doses in the first course. Matching and weighting resulted in populations well-balanced for proposed confounders. We found no differences between patients treated with low-dose erythromycin and control subjects in mortality rate up to day 90: matching HR 0.89 (95% CI, 0.64-1.24), weighting HR 0.95 (95% CI, 0.66-1.36). There were no differences in secondary clinical outcomes. The change in host response biomarker levels from admission to day 4 was similar between erythromycin-treated and control subjects. Conclusion: In this target trial emulation in critically ill patients with sepsis, we could not demonstrate an effect of treatment with low-dose erythromycin on mortality, secondary clinical outcomes, or host response biomarkers.
Proteogenomic Metabolism Dependent Signature Identifies Worse Outcome in Breast And Other Cancers
Authors: Wang Guisong , Shah Punit , Searfoss Richard , Liu Jianfang , Campbell Jamie Leigh , Deyarmin Brenda , Zingmark Rebecca , Mostoller Bradley , Kvecher Leonid , Somiari Stella , Raj-Kumar Praveen-Kumar , Sturtz Lori , Granger Elder , Vahdat Linda , Bountra Chas , Sarangarajan Rangaprasad , Cutler Mary , Narain Niven , Hooke Jeffrey , Shriver Craig , Hu Hai , Kiebish Michael , Kovatich Albert 
Published: March 2022

Abstract
Breast cancer (BrCA) therapeutic selection routinely incorporates clinicopathologic information along with immunohistochemistry (IHC) for ER/PR/HER2/Ki-67. However, this is incomplete and has shortcomings that are seen in clinical outcome differences even within the same subtype. Herein, we analyzed the proteome of 116 HER2-negative primary BrCA samples and subsequently validated a 34-proteogenomic signature in 5,963 BrCA tumor samples from TCGA, METABRIC, and GSE96058 that demonstrated a metabolic enrichment signature impacting overall survival, progression free survival, and response to therapy. The 34-proteogenomic signature selected ER+ BrCA tumors for upstaging to a more triple negative pathophysiological phenotype, herein referred to as Luminal/TN-like (L/T), impacting likelihood for chemotherapy consideration and other therapeutic modalities rather than hormonal therapy alone. Further, analysis of 9,530 tumors across 33 types of cancers in TCGA demonstrated the 34 proteogenomic signature utility in the reclassification of other cancer types into different risk groups.