bluuebunny/crossref_metadata_2025_split huggingface dataset:
Second derivative UV–visible spectroscopy characterizing structural components of dissolved and particulate organic matter in an urbanized river
Authors: Xu Weining , Yu Huibin , Yang Fang , Yang Feng , Liu Dongping , Lu Koutian , Gao Hongjie , Song Yonghui 
Published: March 2022

Abstract
Background
Spatio-temporal variations of structural components of the POM–DOM fractions exhibit in urban rivers, which is valuable information to reveal dynamic migration and transformation within and between the organic matter pools, also provide important support for river water quality improvement and management measures. Second derivative UV–visible spectroscopy (SDUVS) was applied to simultaneously characterize structural components and spatial variations of dissolved (DOM: Diameter < 0.2 μm) and particulate (POM1: 0.2 < diameter < 0.7 μm; POM2: diameter > 0.7 μm) organic matters in an urbanized river of northeast China.

Results
Thirty-six water samples were collected from mainstream and tributaries along a human impact gradient, i.e., rural, town and urban regions. The DOM was a representative fraction for the natural organic matter pool, which was mostly derived from allochthonous and terrestrial sources. Four components C1 to C4 were identified from the POM–DOM fractions by the SDUVS. The C1 associated with phenolic groups and the C2 related to carboxylic groups were dominant for the organic matter pool. The C3 was composed of the primary humificated materials, and the %C3 was kept relatively consistent in the organic matter pool. The C4 presented deeply humificated organic matter with the increase of aromatic and alkyl structures. The average %C4 of the POM pool was higher than that of the DOM pool, indicating that the humification degree of the POM fractions was higher than that of the DOM fraction.

Conclusions
Moreover, the tributaries had a higher average %C4 within the DOM than the mainstream, and trends of the POM pool were similar to the DOM pool. The trophic level of the river water decreased in the order of urban region > town region > rural region, while the molecular sizes of the POM–DOM decreased in the order of rural region > town region > urban region.

Graphical Abstract
School culture and student mental health: a qualitative study in UK secondary schools
Authors: Jessiman Patricia , Kidger Judi , Spencer Liam , Geijer-Simpson Emma , Kaluzeviciute Greta , Burn Anne–Marie , Leonard Naomi , Limmer Mark 
Published: March 2022

AbstractBackgroundThere is consistency of evidence on the link between school culture and student health. A positive school culture has been associated with positive child and youth development, effective risk prevention and health promotion efforts, with extensive evidence for the impact on student mental health. Interventions which focus on socio-cultural elements of school life, and which involve students actively in the process, are increasingly understood to be important for student mental health promotion. This qualitative study was undertaken in three UK secondary schools prior to the implementation of a participative action research study bringing students and staff together to identify changes to school culture that might impact student mental health. The aim was to identify how school culture is conceptualised by students, parents and staff in three UK secondary schools. A secondary aim was to explore which components of school culture were perceived to be most important for student mental health.MethodsAcross three schools, 27 staff and seven parents participated in in-depth interviews, and 28 students participated in four focus groups. The Framework Method of thematic analysis was applied.ResultsRespondents identified elements of school culture that aligned into four dimensions; structure and context, organisational and academic, community, and safety and support. There was strong evidence of the interdependence of the four dimensions in shaping the culture of a school.ConclusionsSchool staff who seek to shape and improve school culture as a means of promoting student mental health may have better results if this interdependence is acknowledged, and improvements are addressed across all four dimensions.
Assessing physical workload among people with musculoskeletal disorders: validity and reliability of the physical workload questionnaire
Authors: Kjønø Lise Grethe , Killingmo Rikke Munk , Vigdal Ørjan Nesse , Grotle Margreth , Storheim Kjersti 
Published: March 2022

Abstract
Background
Demands of physical work are related to musculoskeletal disorders, and hence, important to assess. The Physical Workload Questionnaire (PWQ) is based on 26 items related to physical workload. The PWQ has been translated into Norwegian, but its psychometric properties have not yet been tested. The aim of this study was to assess the validity and reliability of the PWQ among patients with musculoskeletal disorders.

Methods
A cross-sectional study with a test-retest design was conducted to assess construct validity (structural validity and hypothesis testing) and reliability (internal consistency and test-retest reliability) among employed patients with musculoskeletal disorders. Exploratory factor analysis was performed to assess the structural validity and number of items to be included in the Norwegian version of the PWQ. Hypothesis testing was assessed by 14 a priori hypotheses (“known” group, convergent and discriminant validity). Internal consistency was evaluated using Cronbach’s alpha and test-retest reliability by Intraclass Correlation Coefficient (ICC2.1), Standard Error of Measurement (SEMagreement) and Smallest Detectable Change (SDC95%ind).

Results
In total, 115 patients with a mean age (SD) of 46 (9) years were included, of which 48 were included in the reliability analyses. Exploratory factor analysis resulted in two subscales: “Heavy physical work” (15 items, range 0–100) and “Long-lasting postures and repetitive movements” (7 items, range 0–100). No floor or ceiling effects were seen in the subscales. Twelve of the 14 (85%) predefined hypotheses were confirmed. The internal consistency with Cronbach’s alpha was 0.94 and 0.85 on subscales 1 and 2, respectively. Test-retest reliability analyses demonstrated an ICC2.1 of 0.96 (95% CI 0.88, 0.98) and 0.92 (95% CI 0.81, 0.96), SEM of 6.9 and 10.0 and SDC95%ind of 19.2 and 27.7 of subscales 1 and 2, respectively.

Conclusions
The Norwegian version of the PWQ demonstrated good validity and reliability and can be used to evaluate physical workload in patients with musculoskeletal disorders.
Predictive performance of lipid parameters in identifying undiagnosed diabetes and prediabetes: a cross-sectional study in eastern China
Authors: Zhou Yimin , Yang Guoping , Qu Chen , Chen Jiaping , Qian Yinan , Yuan Lei , Mao Tao , Xu Yan , Li Xiaoning , Zhen Shiqi , Liu Sijun 
Published: March 2022

Abstract
Background
Dyslipidaemia is a risk factor for abnormal blood glucose. However, studies on the predictive values of lipid markers in prediabetes and diabetes simultaneously are limited. This study aimed to assess the associations and predictive abilities of lipid indices and abnormal blood glucose.

Methods
A sample of 7667 participants without diabetes were enrolled in this cross-sectional study conducted in 2016, and all of them were classified as having normal glucose tolerance (NGT), prediabetes or diabetes. Blood glucose, blood pressure and lipid parameters (triglycerides, TG; total cholesterol, TC; high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; non-high-density lipoprotein cholesterol, non-HDL-C; and triglyceride glucose index, TyG) were evaluated or calculated. Logistic regression models were used to analyse the association between lipids and abnormal blood glucose. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve was used to assess the discriminatory power of lipid parameters for detecting prediabetes or diabetes.

Results
After adjustment for potential confounding factors, the TyG was the strongest marker related to abnormal blood glucose compared to other lipid indices, with odds ratios of 2.111 for prediabetes and 5.423 for diabetes. For prediabetes, the AUCs of the TG, TC, HDL-C, LDL-C, TC/HDL-C, TG/HDL-C, non-HDL-C and TyG indices were 0.605, 0.617, 0.481, 0.615, 0.603, 0.590, 0.626 and 0.660, respectively, and the cut-off points were 1.34, 4.59, 1.42, 2.69, 3.39, 1.00, 3.19 and 8.52, respectively. For diabetes, the AUCs of the TG, TC, HDL-C, LDL-C, TC/HDL-C, TG/HDL-C, non-HDL-C and TyG indices were 0.712, 0.679, 0.440, 0.652, 0.686, 0.692, 0.705, and 0.827, respectively, and the cut-off points were 1.35, 4.68, 1.42, 2.61, 3.44, 0.98, 3.13 and 8.80, respectively.

Conclusions
The TyG, TG and non-HDL-C, especially TyG, are accessible biomarkers for screening individuals with undiagnosed diabetes.
Impact of proton pump inhibitor management committee’s multifaceted interventions on acid suppressant prescribing patterns in outpatient and emergency departments
Authors: Liu Lu , Yu Yongqi , Fan Qingze , Wu Zhigui , Li Xiuying , Luo Hongli 
Published: March 2022

Abstract
Background
A nationwide campaign for rational proton pump inhibitor (PPI) use launched in 2015 had a positive impact for hospitalized patients PPI use. But there were few studies focusing on the rational use of PPIs in outpatients. In 2018, the PPI management committee conducted a year-long intervention on the appropriate use of PPIs in outpatient and emergency departments, including clinical pharmacist interventions and stewardship interventions. The purpose of this study was to examine the impact of the PPI management committee’s multifaceted interventions by comparing the real-world acid suppressant prescribing patterns for outpatients before (2017) and after intervention (2019) at a Chinese tertiary teaching hospital.

Methods
Prescriptions containing any acid suppressant in outpatient and emergency departments in baseline (2017) and postintervention (2019) periods were extracted from the hospital information system and the prescription automatic screening system. Acid suppressant prescribing patterns were evaluated based on primary diagnoses and patient demographics. The prescribed acid suppressants stratified using age groups (< 7, 7–17, 18–45, 46–65, 66–85 and > 85 years) were also examined.

Result
The utilization rate of acid suppressant in 2017 and 2019 was 2.5% (41,165/1,619,366) and 2.2% (49,550/2,236,471), respectively (P < 0.0001). 60,135 acid suppressant prescriptions were obtained in 2017 and 73,275 in 2019. The rate of acid suppressant prescriptions for the approved indications significantly increased from 62.6% (2017) to 65.4% (2019) (P < 0.0001). Prescriptions diagnosed as abnormal symptoms, signs and clinical manifestations, decreased in 2019 (13.0% vs. 16.5%, P < 0.0001). The most frequently prescribed PPIs differed between 2017 and 2019 (rabeprazole 2017 vs. esomeprazole 2019). Omeprazole was the most common PPI and cimetidine was the most common H2RA prescribed to patients aged < 18 years in 2017 and 2019. A total of CNY11.83 million was spent on acid suppressants in 2019, accounting for about 48.7% of total medication cost, increased by 11.3% from 2017 (37.4%).

Conclusion
The proportion of acid suppressant prescriptions for approved indications was enhanced after the PPI management committee’s multifaceted interventions, but there were still some problems in the selection of acid suppressants.
Local nebulization of 1α,25(OH)2D3 attenuates LPS-induced acute lung inflammation
Authors: Serré Jef , Mathyssen Carolien , Ajime Tom Tanjeko , Heigl Tobias , Verlinden Lieve , Maes Karen , Verstuyf Annemieke , Cataldo Didier , Vanoirbeek Jeroen , Vanaudenaerde Bart , Janssens Wim , Gayan-Ramirez Ghislaine 
Published: March 2022

Abstract
Background
Evidence supports a critical role of vitamin D status on exacerbation in chronic obstructive pulmonary disease, indicating the need to avoid vitamin D deficiency in these patients. However, oral vitamin D supplementation is limited by the potential risk for hypercalcemia. In this study, we investigated if local delivery of vitamin D to the lungs improves vitamin D-mediated anti-inflammatory action in response to acute inflammation without inducing hypercalcemia.

Methods
We studied vitamin D sufficient (VDS) or deficient (VDD) mice in whom 1α,25(OH)2D3 (0.2 μg/kg) or a vehicle followed by lipopolysaccharide (LPS 25 µg) were delivered to the lung as a micro-spray.

Results
Local 1α,25(OH)2D3 reduced LPS-induced inflammatory cells in bronchoalveolar lavage (BAL) in VDS (absolute number of cells: − 57% and neutrophils − 51% p < 0.01) and tended to diminish LPS-increased CXCL5 BAL levels in VDS (− 40%, p = 0.05) while it had no effect on CXCL1 and CXCL2 in BAL and mRNA in lung of VDS and VDD. It also significantly attenuated the increased IL-13 in BAL and lung, especially in VDD mice (− 41 and − 75%, respectively). mRNA expression of Claudin-18 in lung was significantly lower in VDS mice with local 1α,25(OH)2D3 while Claudin-3, -5 and -8 mRNA levels remained unchanged. Finally, in VDD mice only, LPS reduced lung mRNA expression of adhesion junction Zona-occludens-1, in addition to increasing uric acid and total protein in BAL, which both were prevented by local 1α,25(OH)2D3.

Conclusion
Under normal levels of vitamin D, local 1α,25(OH)2D3 nebulization into the lung efficiently reduced LPS induction of inflammatory cells in BAL and slightly attenuated LPS-increase in CXCL5. In case of severe vitamin D deficiency, although local 1α,25(OH)2D3 nebulization failed to significantly minimize cellular inflammation in BAL at this dose, it prevented epithelial barrier leakage and damage in lung. Additional research is needed to determine the potential long-term beneficial effects of local 1α,25(OH)2D3 nebulization on lung inflammation.
Left atrial contraction strain and controlled preload alterations, a study in healthy individuals
Authors: Gottfridsson Peter , A’Roch Roman , Lindqvist Per , Law Lucy , Myrberg Tomi , Hultin Magnus , A’Roch Alexander , Haney Michael 
Published: March 2022

Abstract
Background
In order to assess left atrial contractile function in disturbed circulatory conditions, it is necessary to have a clear understanding of how it behaves in a normal resting state with changes in loading conditions. However, currently the understanding of this relationship is incomplete. We hypothesize that in healthy individuals, left atrial contraction strain and its peak strain rate are increased or decreased by increasing or decreasing preload, respectively.

Methods
Controlled maneuvers used to change preload included continuous positive airway pressure by mask (CPAP 20 cmH2O) for preload decrease, and passive leg raise (15 degrees angle) for preload increase. Cardiac ultrasound 4-chamber views of the left atria and left ventricle were acquired at baseline and during maneuver. Acquired images were post processed and analyzed offline. Comparisons were made using paired t-test and means with 95% confidence interval.

Results
There were 38 participants, complete results were obtained from 23 in the CPAP maneuver and 27 in the passive leg raise maneuver. For the CPAP group, left atrial contraction strain was 11.6% (10.1 to 13.1) at baseline and 12.8% (11.0 to 14.6) during the maneuver (p = 0.16). Left atrial contraction peak strain rate was − 1.7 s− 1 (− 1.8 to − 1.5) at baseline and − 1.8 s− 1 (− 2.0 to − 1.6) during the maneuver (p = 0.29). For the passive leg raise-group, left atrial contraction strain was 10.1% (9.0 to 11.2) at baseline and 10.8% (9.4 to 12.3) during the maneuver (p = 0.28). Left atrial contraction peak strain rate was − 1.5 s− 1 (− 1.6 to − 1.4) at baseline and − 1.6 s− 1 (− 1.8 to − 1.5) during the maneuver (p = 0.29). Left atrial area, an indicator of preload, increased significantly during passive leg raise and decreased during CPAP.

Conclusion
In healthy individuals, left atrial contraction strain and its peak strain rate seem to be preload-independent.

Trial registration
The study was 2018-02-19 registered at clinicaltrials.gov (NCT03436030).
Mesenchymal stem/stromal cell therapy for COVID-19 pneumonia: potential mechanisms, current clinical evidence, and future perspectives
Authors: Yao Weiqi , Shi Lei , Zhang Yun , Dong Haibo , Zhang Yu 
Published: March 2022

AbstractThe coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread into more than 200 countries and infected approximately 203 million people globally. COVID-19 is associated with high mortality and morbidity in some patients, and this disease still does not have effective treatments with reproducibly appreciable outcomes. One of the leading complications associated with COVID-19 is acute respiratory distress syndrome (ARDS); this is an anti-viral host inflammatory response, and it is usually caused by a cytokine storm syndrome which may lead to multi-organ failure and death. Currently, COVID-19 patients are treated with approaches that mostly fall into two major categories: immunomodulators, which promote the body’s fight against viruses efficiently, and antivirals, which slow or stop viruses from multiplying. These treatments include a variety of novel therapies that are currently being tested in clinical trials, including serum, IL-6 antibody, and remdesivir; however, the outcomes of these therapies are not consistently appreciable and remain a subject of debate. Mesenchymal stem/stromal cells (MSCs), the multipotent stem cells that have previously been used to treat viral infections and various respiratory diseases such as ARDS exhibit immunomodulatory properties and can ameliorate tissue damage. Given that SARS-CoV-2 targets the immune system and causes tissue damage, it is presumable that MSCs are being explored to treat COVID-19 patients. This review summarizes the potential mechanisms of action of MSC therapy, progress of MSC, and its related products in clinical trials for COVID-19 therapy based on the outcomes of these clinical studies.
Oryzae pathotype of Magnaporthe oryzae can cause typical blast disease symptoms on both leaves and spikes of wheat under a growth room condition
Authors: Paul Sanjoy Kumar , Mahmud Nur Uddin , Gupta Dipali Rani , Rani Kanistha , Kang Houxiang , Wang Guo-Liang , Jankuloski Ljupcho , Islam Tofazzal 
Published: March 2022

AbstractBlast diseases of rice and wheat are known to be caused by the specific pathotypes of Magnaporthe oryzae (syn. Pyricularia oryzae), M. oryzae Oryzae (MoO) and M. oryzae Triticum (MoT), respectively. Rice blast disease has been seen in Bangladesh from a very ancient time. However, Bangladesh’s first epidemic outbreak of wheat blast was recorded in 2016. This study aimed to investigate the cross-infection reactions of MoO and MoT in rice and wheat in a growth room condition. Artificial inoculation was done at vegetative and reproductive phases of both wheat and rice plants in a completely randomized design using virulent isolates of MoO and MoT. Artificial inoculation with MoO resulted in foliar symptoms with typical eye-shaped lesions as well as partially bleached or completely white head symptoms in both wheat and rice plants. On the other hand, MoT produced blast symptoms only on the leaves and spikes of wheat. Molecular analyses using PCR amplification (with Pot2, MoT3 and MoT6099 primers) and a recently developed rapid detection PCRD strip confirmed the presence of MoT and MoO pathotypes in the symptomatic plant samples. Our results demonstrated that MoO pathotype can infect the leaves and spikes of wheat but MoT is unable to infect rice plants under the same controlled environment in Bangladesh. This study has revealed the vulnerability of wheat to MoO pathotype and an urgent need to understand the molecular mechanism underlying host-specificity of the blast fungus M. oryzae. Our results also provided evidence for a potential wheat blast epidemic by MoO in many rice–wheat inter-cropping regions as climate change intensifies. A comprehensive study is needed to have a better understanding on the variability in virulence of MoO and MoT isolates in infecting wheat and rice under controlled environment by the inclusion of a large number of isolates and crop varieties/genotypes.
A comparative study: quality of life, self-competence, and self-liking among the caregivers of children with attention deficit hyperactivity disorder and other non-ADHD children
Authors: Ahmed Mona Gamal Abd Elnaser , Felemban Ebaa Marwan , El-slamoni Marwa Abd El-fatah Ali 
Published: March 2022

Abstract
Background
The presence of attention deficit hyperactive disorder (ADHD) causes great impairment in social and professional activities as well as in the quality of life (QOL) and increases level of parental stress.

Objective
This study aimed to compare the QOL, self-competence, and self-liking among the caregivers of ADHD and non-ADHD children.

Method
A descriptive cross-sectional study was conducted on 216 caregivers. They were divided into two groups: caregivers of children with ADHD and caregivers of children without ADHD.

Setting
This study was conducted in the Elsinbellawin City at Dakahlia Governorate in Egypt. Tools used were socio-demographic data sheet and WHO Quality of Life Scale-Brief (WHOQOL-Brief) and self-liking/self-competence scale.

Results
Our results showed that all QOL dimensions of the caregivers of ADHD children were markedly deteriorated, if compared to those of non-ADHD children, and two thirds of caregivers of ADHD children suffered from poor level quality of life (QOL). Caregivers of non-ADHD children had fair level of self-competence but a good level of self-liking. Caregiver of ADHD children who had no work or history of medical diseases has a fair level of QOL and self-competence but a good level of self-liking.

Conclusions
We found that caregivers of ADHD children have fair levels of QOL, self-liking, and self-competence, if compared to those of non-ADHD children. There are statistically significant correlations between QOL, self-competence, and self-liking among both caregivers of both non-ADHD children and ADHD children.
Ultrafast (600 ps) α-ray scintillators
Authors: Lin Richeng , Zhu Yanming , Chen Liang , Zheng Wei , Xu Mengxuan , Ruan Jinlu , Li Renfu , Li Titao , Lin Zhuogeng , Cheng Lu , Ding Ying , Huang Feng , Ouyang Xiaoping 
Published: March 2022

AbstractLarge-size scintillators with high efficiency and ultrafast radiation fluorescence have shown more potential in the applications to ionizing radiation detection of medical diagnosis, nuclear control and high-energy physics. Currently, although traditional scintillators have made tremendous progress in scintillation efficiency, there are still challenges left in fluorescence lifetime. Faced with that problem, we adopted 2-inch ZnO as the substrate and doped gallium as activator to realize an ultrafast fluorescence excited by α-ray, of which the decay time is only 600 ps that is the shortest scintillation decay time reported so far. The results show that the shallow donor related with gallium not only effectively suppresses band-edge self-absorption, but makes ultrafast radiation possible, which gets gallium-doped ZnO as a potential scintillator for high-quality ultrafast dynamic imaging proved.