bluuebunny/crossref_metadata_2025_split huggingface dataset:
Black soldier fly (Hermetia illucens, L.) larvae meal improves growth performance, feed efficiency and economic returns of Nile tilapia (Oreochromis niloticus, L.) fry
Authors: Limbu Samwel Mchele , Shoko Amon Paul , Ulotu Eusebia Ernest , Luvanga Siwema Amran , Munyi Fridah Mukiri , John John Obedy , Opiyo Mary Adhiambo 
Published: May 2022

AbstractInsects have been proposed as potential alternative animal protein sources to replace fishmeal (FM), which is expensive and has limited availability for fish feed formulation. However, studies on the effects of replacing FM with black soldier fly (Hermetia illucens) larvae (BSF‐L) on growth performance of Nile tilapia (Oreochromis niloticus) fry, water quality and economic benefits are currently limited. This study determined the effects of replacing 100% FM, 75% FM, 50% FM, 25% FM and 0% FM with cheap BSF‐L meal, hereafter referred to as BSF‐L0, BSF‐L25, BSF‐L50, BSF‐L75 and BSF‐L100 diets, respectively for rearing all‐male Nile tilapia fry produced by YY technology. The study further determined the optimum percentage of BSF‐L meal for maximum growth of Nile tilapia fry. A total of 2400 visually healthy Nile tilapia fry weighing 0.001 g were randomly stocked into 20 plastic tanks (120 fry per tank, four replicates per treatment) and fed the BSF‐L diets for 12 weeks. The BSF‐L75 diet increased significantly specific growth rate, total weight gain, Zihler's index of fry and nitrate in the culture water but reduced feed conversion ratio of diet and total suspended solids in the culture water (p < 0.05). Feeding the Nile tilapia fry with BSF‐L50 diet increased significantly hepatosomatic index (p < 0.05). The diets with BSF‐L75 and BSF‐L100 reduced significantly the incidence cost by 31.97% and 28.77% (p < 0.05), and increased profit index by 3.97 and 3.44%, respectively. The optimum percentage of BSF‐L inclusion required for maximum growth performance of Nile tilapia fry was estimated as 81% to 84% based on polynomial analysis. Taken together, feeding Nile tilapia fry with diets containing 81% to 84% BSF‐L meal improved growth performance. The BSF‐L75 diet enhanced feed efficiency and had no deleterious effect on the liver and intestines. Meanwhile, it improved nitrate concentration for increased natural productivity. Incorporating 75% BSF‐L meal in diets for Nile tilapia fry reduced 30% of feed cost leading to 4% higher economic returns.
Smart connected worker edge platform for smart manufacturing: Part 1—Architecture and platform design
Authors: Kim Yoon G. , Donovan Richard P. , Ren Yutian , Bian Shijie , Wu Tongzi , Purawat Shweta , Manzo Anthony J. , Altintas Ilkay , Li Bingbing , Li Guann‐Pyng 
Published: May 2022

AbstractThe challenge of sustainably producing goods and services for healthy living on a healthy planet requires simultaneous consideration of economic, societal, and environmental dimensions in manufacturing. Enabling technology for data driven manufacturing paradigms like Smart Manufacturing (a.k.a. Industry 4.0) serve as the technological backbone from which sustainable approaches to manufacturing can be implemented. Unfortunately, these technologies are typically associated with broader and deeper factory automation that is often too expensive and complex for the small and medium sized manufacturers (SMMs) that comprise the majority of manufacturing business in the USA and for whom their most valuable asset are the people whose jobs automation while replace. This paper describes an edge intelligent platform to integrate internet‐of‐things technologies with computing hardware, software, computational workflows for machine learning, and data ingestion, enabling SMMs to transition into smart manufacturing paradigms by leveraging the intelligence of their people. The platform leverages consumer grade electronics and sensors (affordable and portable), customized software with open source software packages (accessible), and existing communication network infrastructures (scalable). The software systems are implemented via Kubernetes orchestration of Docker containerization to ensure scalability and programmability. The platform is adaptive via computational workflow engines that produce information from data by processing with low‐cost edge computing devices while efficiently accessing resources of cloud servers as needed. The proposed edge platform connects workers to technological resources that provide computational intelligence (i.e., silicon‐based sensing and computation for data collection and contextualization) to enable decision making at the edge of advanced manufacturing.
Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors
Authors: Liu Hui , Dehestani Mohammad , Blauwendraat Cornelis , Makarious Mary B. , Leonard Hampton , Kim Jonggeol J. , Schulte Claudia , Noyce Alastair , Jacobs Benjamin M. , Foote Isabelle , Sharma Manu ,   International Parkinson's Disease Genomics Consortium; Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease Consortium, Nalls Mike , Singleton Andrew , Gasser Thomas , Bandres‐Ciga Sara 
Published: May 2022

ObjectiveThe aim of the current study is to understand why some individuals avoid developing Parkinson disease (PD) despite being at relatively high genetic risk, using the largest datasets of individual‐level genetic data available.MethodsWe calculated polygenic risk score to identify controls and matched PD cases with the highest burden of genetic risk for PD in the discovery cohort (International Parkinson's Disease Genomics Consortium, 7,204 PD cases and 9,412 controls) and validation cohorts (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease, 8,968 cases and 7,598 controls; UK Biobank, 2,639 PD cases and 14,301 controls; Accelerating Medicines Partnership–Parkinson's Disease Initiative, 2,248 cases and 2,817 controls). A genome‐wide association study meta‐analysis was performed on these individuals to understand genetic variation associated with resistance to disease. We further constructed a polygenic resilience score, and performed multimarker analysis of genomic annotation (MAGMA) gene‐based analyses and functional enrichment analyses.ResultsA higher polygenic resilience score was associated with a lower risk for PD (β = −0.054, standard error [SE] = 0.022, p = 0.013). Although no single locus reached genome‐wide significance, MAGMA gene‐based analyses nominated TBCA as a putative gene. Furthermore, we estimated the narrow‐sense heritability associated with resilience to PD (h2 = 0.081, SE = 0.035, p = 0.0003). Subsequent functional enrichment analysis highlighted histone methylation as a potential pathway harboring resilience alleles that could mitigate the effects of PD risk loci.InterpretationThe present study represents a novel and comprehensive assessment of heritable genetic variation contributing to PD resistance. We show that a genetic resilience score can modify the penetrance of PD genetic risk factors and therefore protect individuals carrying a high‐risk genetic burden from developing PD. ANN NEUROL 2022;92:270–278
Effect of Differential Backbone Di‐substitution of Gamma Amino Acid Residues on the Conformation and Assembly of their Fmoc Derivatives in Solid and Solution States
Authors: Debnath Swapna , Ghosh Suvankar , Kumar Dinesh , Vasudev Prema G. , Satpati Priyadarshi , Chatterjee Sunanda 
Published: May 2022

AbstractWe studied the effect of variable backbone dimethyl‐substitution of γ amino acid residues (γ2,2, γ3,3 and γ4,4) on the conformation and assembly, in crystals and solution of their Fmoc derivatives. The crystal structure of γ2,2 and γ4,4 derivatives showed distinct conformations (open/close for γ2,2/γ4,4) that differed in torsion angles, hydrogen‐bonding and most importantly the π‐π Fmoc‐stacking interactions (relatively favourable for γ4,4‐close). Fmoc derivatives existed in an equilibrium between major‐monomeric (low energy, non‐hydrogen bonded) and minor‐dimeric (high energy, hydrogen bonded) populations in solution. The rate of major/minor population exchange was dependent on the position of substitution, highest being for γ4,4 derivative. In solution, assembly of Fmoc derivatives was solvent dependent, but it was independent of the position of geminal substitution. Crystallization was primarily governed by the stabilization of high‐energy dimer by favourable π‐π stacking involving Fmoc moieties. High free‐energy of the dimers (γ2,2‐close, γ3,3‐open/close) offset favourable stacking interactions and hindered crystallization.
Stability analysis of Markovian jump systems with delayed impulses
Authors: Wang Guoliang , Ren Yunshuai 
Published: May 2022

AbstractThis paper addresses stability for Markovian jump systems with delayed impulses. The delayed impulse has a largely negative effect on the system stability and is not easy to be studied. The main reason is that so many factors such as Markovian switching, impulse, and time‐varying delay are simultaneously contained and make its analysis complicated and difficult. In order to analyze these factors clearly, some novel enlarging techniques are presented and used to establish linear matrix inequality (LMI) conditions ultimately. Based on the given methods, more situations such as impulsive instant sequence satisfying a renewal process and Poisson process, respectively, are further studied and better than ones without considering such properties. Two numerical examples are used to show the effectiveness and superiority of the methods.
Beneficial effect of steam on synthesis of hierarchically porous zeolite‐templated carbons
Authors: Han Jinju , Kim Kyoungsoo 
Published: May 2022

AbstractHierarchically meso‐/microporous carbons were synthesized using nanocrystalline beta zeolite as a sacrificial template. The zeolite template possessed intercrystalline mesopores in addition to ordered micropores of the nanocrystals. Various amounts of steam were used with a carbon source, such as ethylene, propylene or acetonitrile, to generate a carbon structure inside the template. The synthesis results showed that adding a suitable amount of steam gave rise to faithful replication of the ordered microporous structure, while the intercrystalline mesopores were retained. That is, the carbon structure was formed selectively inside nanocrystalline zeolites rather than at the exterior by the steam addition. Microscopic observation and thermogravimetric analysis revealed that steam oxidized the carbon species deposited at the external surface of zeolite nanocrystals, and hence inhibited the undesirable carbon deposition. Furthermore, such a beneficial effect of steam could be applied for the carbon synthesis using other type zeolite templates.
Proteomics analyses of Xiaopi granules in N‐methyl‐N′‐nitro‐N‐nitrosoguanidine–induced gastric epithelial dysplasia rat model using LC–MS
Authors: Peng Jisheng , Chen Zehui , Liang Huazheng , Yang Jinxiang 
Published: May 2022

AbstractXiaopi granules have been shown to ameliorate gastric epithelial dysplasia in patients. However, the therapeutic mechanism is unclear. Herein, the proteomics method was applied to identify the differentially expressed proteins and related pathways. Sixty male Sprague–Dawley rats were randomly divided into four groups: control (C group, n = 10), model (M group), Xiaopi granules (X group), and vitacoenzyme (V group). The rat gastric epithelial dysplasia model was established by intragastrically administering N‐methyl‐N′‐nitro‐N‐nitrosoguanidine and ranitidine and by orally administering 0.05% ammonia solution. After 12 weeks, the stomach tissue was analyzed by hematoxylin and eosin staining and proteomics analyses. Western‐blot analysis was applied to further validate the proteomics results. Compared to the M group, levels of 326 and 350 proteins were altered significantly in the X and V groups (1.5‐fold, p < 0.05), which were significantly enriched in digestion, metabolism, coagulation, and cell apoptosis. CELA2A, GHRL, NDUFB9, and PGC were significantly upregulated (p < 0.0001), whereas CLCA1, PLG, and DAC2 were downregulated (p < 0.001 or 0.0001) in the M group vs. the C group. The change in these proteins could be reversed after the treatment of Xiaopi granules or vitacoenzyme tablets. Xiaopi granules ameliorated gastric epithelial dysplasia by intervening in digestion, metabolism, blood coagulation, cell apoptosis, and other related pathways.
Behavioral features in child and adolescent huntingtin gene‐mutation carriers
Authors: Reasoner Erin E. , van der Plas Ellen , Al‐Kaylani Hend M. , Langbehn Douglas R. , Conrad Amy L. , Schultz Jordan L. , Epping Eric A. , Magnotta Vincent A. , Nopoulos Peggy C. 
Published: May 2022

AbstractIntroductionWe compared neuropsychiatric symptoms between child and adolescent huntingtin gene‐mutation carriers and noncarriers. Given previous evidence of atypical striatal development in carriers, we also assessed the relationship between neuropsychiatric traits and striatal development.MethodsParticipants between 6 and 18 years old were recruited from families affected by Huntington's disease and tested for the huntingtin gene expansion. Neuropsychiatric traits were assessed using the Pediatric Behavior Scale and the Behavior Rating Inventory of Executive Function. Striatal volumes were extracted from 3T neuro‐anatomical images. Multivariable linear regression models were conducted to evaluate the impact of group (i.e., gene nonexpanded [GNE] or gene expanded [GE]), age, and trajectory of striatal growth on neuropsychiatric symptoms.ResultsThere were no group differences in any behavioral measure with the exception of depression/anxiety score, which was higher in the GNE group compared to the GE group (estimate = 4.58, t(129) = 2.52, FDR = 0.051). The growth trajectory of striatal volume predicted depression scores (estimate = 0.429, 95% CI 0.15:0.71, p = .0029), where a negative slope of striatal volume over time was associated with lower depression/anxiety.ConclusionsThe current findings show that GE children may have lower depression/anxiety compared to their peers. Previously, we observed a unique pattern of early striatal hypertrophy and continued decrement in volume over time among GE children and adolescents. In contrast, GNE individuals largely show striatal volume growth. These findings suggest that the lower scores of depression and anxiety seen in GE children and adolescents may be associated with differential growth of the striatum.
Mesenchymal chondrosarcoma: An Australian multi‐centre cohort study
Authors: Strach Madeleine C. , Grimison Peter S. , Hong Angela , Boyle Richard , Stalley Paul , Karim Rooshdiya , Connolly Elizabeth A. , Bae Susie , Desai Jayesh , Crowe Philip , Singhal Nimit , Bhadri Vivek A. 
Published: May 2022

AbstractBackgroundMesenchymal chondrosarcoma (MCS) is an ultra‐rare sarcoma that follows a more aggressive course than conventional chondrosarcoma. This study evaluates prognostic factors, treatments (surgery, chemotherapy, and radiation), and outcomes in an Australian setting.MethodsWe collected demographics, clinicopathological variables, treatment characteristics, and survival status from patients with MCS registered on the national ACCORD sarcoma database. Outcomes include overall survival (OS) and progression‐free survival (PFS).ResultsWe identified 22 patients with MCS between 2001–2022. Median age was 28 (range 10–59) years, 19 (86%) had localised disease at diagnosis of whom 16 had surgery (84%), 11 received radiation (58%), and 10 chemotherapy (53%). Ten (52%) developed recurrence and/or metastases on follow‐up and three patients with initial metastatic disease received surgery, radiation, and chemotherapy. At a median follow‐up of 50.9 (range 0.4–210) months nine patients had died. The median OS was 104.1 months (95% CI 25.8–182.3). There was improved OS for patients with localised disease who had surgical resection of the primary (p = 0.003) and those with ECOG 0–1 compared to 2–3 (p = 0.023) on univariate analysis.ConclusionsThis study demonstrates contemporary Australian treatment patterns of MCS. The role of chemotherapy for localised disease remains uncertain. Understanding treatment patterns and outcomes help support treatment decisions and design of trials for novel therapeutic strategies.
The same only different? How a pandemic shapes consumer organic food purchasing
Authors: Sohn Stefanie , Seegebarth Barbara , Woisetschläger David M. 
Published: May 2022

AbstractOrganic food consumption is seen as a key strategy to alleviate both environmental and health problems. Although consumer purchasing of organic food has regularly been studied, major gaps exist in the literature. Knowledge is missing on how contextual factors, such as pandemics (e.g., COVID‐19 pandemic), affect individuals' purchasing of organic food. Therefore, the aim of this research is to examine the effect of a pandemic on organic food purchasing. To provide evidence on this effect, data collected at two points in time (before the COVID‐19 pandemic and during the first wave of the COVID‐19 pandemic) from 429 German consumers was analyzed with structural equation modeling. The results showed that pandemics positively influence both consumer quality consciousness (β = .116) and health consciousness (β = .106) and thereby enhance organic food purchasing. However, pandemics were not found to shape a consumers' environmental consciousness (β = −.005). Additional analyses showed that the effects of a pandemic are not equal for all consumer segments and that consumers' income occupies—different than consumers' age, gender, and education—a decisive role. For instance, pandemics promote consumers' health consciousness only for consumers of lower than of higher income. These findings yield the diverse implications for practitioners and public policy.
Endomyocardial fibrosis in a non‐tropical patient who presented with chest pain mimicking ACS and left ventricular thrombus, case report
Authors: Matarneh Ahmad S. , Hailan Yousef M. Ali , Abdul Karim Sabir , Al Kuwari Maryam A. , Dabdoob Wafer A. 
Published: May 2022

AbstractEndomyocardial fibrosis (EMF) is a disease known to cause restrictive cardiomyopathy. It shows a high prevalence in tropical countries. Several triggering factors have been proposed. However, the pathogenesis is still a mystery. The disease is progressive, and the outcome is generally unfavorable. The most common symptom is heart failure. However, an atypical presentation may be expected. Our case presented with symptoms suggestive of ischemia and missed diagnosis initially as ischemic cardiomyopathy. This report aims to increase the attention and awareness of this disease. We present a case of a 53‐year‐old man referred to the emergency department for sudden chest pain, left‐sided and non‐radiating lasted for several minutes, awoke him from sleep with no associated symptoms. He is known to have Diabetes type‐2 and hypertension on oral therapy. Cardiac markers were within the normal limit. The patient was discharged home with an appointment at the cardiology outpatient clinic. Echocardiography was done and revealed mildly reduced left ventricular (LV) systolic function, Ejection Fraction of 46%, asymmetric LV hypertrophy affecting the apical segments with aneurysm, and calcified apical thrombus. CT coronary angiography was done with non‐significant Left Anterior Descending artery lesions and left ventricular hypertrophy affecting the apex with calcified apical thrombus. Further investigation by cardiac MRI revealed apical thrombus and late apical uptake suggesting Endomyocardial Fibrosis of possible eosinophilic etiology. The patient continued to have attacks of similar chest pain, for which stress cardiac MRI was done and was negative for ischemia. Another diagnostic workup was done, including hematological and serological tests such as Antinuclear Antibodies and Schistosoma Antibodies. The patient was kept on valsartan and Bisoprolol with oral anticoagulant (vitamin K antagonist) and Rosuvastatin. EMF may have a heterogeneous presentation and should be considered in a patient with calcific apical thrombus without previous history of cardiac problem, even in the non‐tropical region.
Laparoscopic cholecystectomy after percutaneous transhepatic gallbladder drainage for acute cholecystitis in a patient with a left ventricle assist device: A case report and brief review of the literature (with video)
Authors: Hanaki Takehiko , Sunaguchi Teppei , Goto Keisuke , Morimoto Masaki , Murakami Yuki , Tokuyasu Naruo , Takano Shuichi , Sakamoto Teruhisa , Hasegawa Toshimichi , Fujiwara Yoshiyuki 
Published: May 2022

AbstractFor acute cholecystitis in patients with left ventricular assist devices, the use of percutaneous transhepatic gallbladder drainage to calm inflammation before planned laparoscopic cholecystectomy may be helpful in safely adjusting anticoagulation and in performing safe laparoscopic cholecystectomy, as demonstrated in this case.
A new variant of MYCN gene as a cause of Feingold syndrome
Authors: Zeka Naim , Bejiqi Ramush , Gerguri Abdurrahim , Zogaj Leonore , Jashari Haki 
Published: May 2022

AbstractFeingold syndrome 1 (FS1) is a rare disorder that is inherited in autosomal dominant manner with full penetrance but with variable expressivity. The most common phenotypical features described are finger and toe anomalies, microcephaly, short stature, and intestinal atresia. Dysmorphic features, intellectual disability and other organ anomalies are less frequently described. Here, we present a 7‐year‐old boy with severe intellectual disability who is diagnosed with FS1 syndrome caused by a new heterozygous variant of MYCN gene
Interspecific variation in sex‐specific gustatory organs in Drosophila
Authors: Kopp Artyom , Barmina Olga 
Published: May 2022

AbstractDrosophila males use leg gustatory bristles to discriminate between male and female cuticular pheromones as an important part of courtship behavior. In Drosophila melanogaster, several male‐specific gustatory bristles are present on the anterior surface of the first tarsal segment of the prothoracic leg, in addition to a larger set of gustatory bristles found in both sexes. These bristles are thought to be specialized for pheromone detection. Here, we report the number and location of sex‐specific gustatory bristles in 27 other Drosophila species. Although some species have a pattern similar to D. melanogaster, others lack anterior male‐specific bristles but have many dorsal male‐specific gustatory bristles instead. Some species have both anterior and dorsal male‐specific bristles, while others lack sexual dimorphism entirely. In several distantly related species, the number of gustatory bristles is much greater in males than in females due to a male‐specific transformation of ancestrally mechanosensory bristles to a chemosensory identity. This variation in the extent and pattern of sexual dimorphism may affect the formation and function of neuronal circuits that control Drosophila courtship and contribute to the evolution of mating behavior.