bluuebunny/crossref_metadata_2025_split huggingface dataset:
Absence of the Transcendental Signified: Tracing the Dynamics of Intertextuality in Selected Essays of Shoaib Bin Hassan
Authors: Ahsan Rija , Ishfaq Sarah 
Published: March 2022

This research aimed to analyse selected essays from the anthology Aesthetics of Incompleteness by Shoaib Bin Hassan to prove the intertextual nature of language in the Pakistani postmodern Anglophone literature. The objective was to explore the linguistic and thematic intertextual underpinnings to highlight how literary, cultural, and historical narratives are interwoven in the text, which denotes the absence of a transcendental signified and the text becomes a web of textuality. Using a deconstructionist approach, the study postulated that language bears the absence of a transcendental signified, which marks its decentred nature, complemented by the concept of intertextuality. In this research, the language and referents employed by Hassan in his essays were specifically analysed. This study fills the research gap that appears in contemporary Pakistani Anglophone literature due to a lack of poststructuralist research. The critical ideas propounded by (Derrida, 2009; Catherine Besley, 2008; Peter Barry, 2007; Leitch, 1983; Maria Jesus Martinez Alfaro, 1996) served as the basis of the theoretical framework utilized in this study and secondary texts for this research. Opening up similar poststructuralist viewpoints for the exploration of postmodern literature, this study paves the way for more research on Pakistani Anglophone literature intended to analyse textual innovations, specifically in contemporary texts. Moreover, since literary essay is a withering genre in Pakistani Anglophone literature, this research is likely to play a significant role in rejuvenating its importance and adding a new literary dimension to it.
Keywords: decentred, intertextuality, language, transcendental signified
Pengaruh Keselamatan dan Kesehatan Kerja (K3) Terhadap Produktivitas Kerja Karyawan
Authors: Swatika Brilian , Wibowo Pipid Ari , Abidin Zaenal 
Published: March 2022

Produktivitas ialah suatu pendekatan interdisipliner untuk menetapkan tujuan yang efektif. Terdapat rendahnya tingkat produktivitas kerja pada bagian nabati PT. Air Mancur. Tujuan penelitian ini untuk menganalisis pengaruh kesehatan dan keselamatan kerja (K3) terhadap produktivitas kerja karyawan bagian nabati PT. Air Mancur. Populasi dalam penelitian ini yaitu karyawan bagi nabati PT. Air Mancur sebanyak 21 orang. Jenis penelitian kuantitatif dengan jenis cross sectional. Penelitian ini menggunakan teknik ­non-probability sampling dengan teknik total sampling dimana jumlah sampel dalam penelitian sama dengan jumlah populasi. Analisis data berupa uji validitas, uji reliabilitas, uji korelasi, uji asumsi klasik, analisis regresi linier berganda dan uji koefisien determinan. Hasil penelitian menunjukan bahwa secara simultan terdapat pengaruh keselamatan dan kesehatan kerja (K3) terhadap produktivitas kerja (Pv=0,000; r=0,616, Adjust r=0,574), secara parsial keselamatan kerja (Pv=0,000; r=0,721), kesehatan kerja (Pv=0,000, r=0,729) terhadap produktivitas kerja. Berdasarkan hasil penelitian dapat disimpulkan kesehatan dan keselamatan kerja (K3) memiliki pengaruh sebesar 57,4% terhadap produktivitas kerja karyawan dan 42,6% dipengaruhi faktor lainnya. Hasil penelitian ini dapat dijadikan masukan bagi PT. Air Mancur supaya lebih memperhatikan faktor keselamatan dan kesehatan kerja (K3), upaya-upaya strategis berkaitan dengan fasilitas dan pelatihan K3.
Pengaruh Jenis Berita COVID-19 terhadap Tingkat Kecemasan Mahasiswa
Authors: Utami Meira Oryza Vidia , Ayuningbudi Fadjrina Hapsari Woro , Putri Tafia Afina , Abidin Fitri Ariyanti 
Published: March 2022

Seiring dengan situasi pandemi COVID-19, media massa didominasi dengan pemberitaan mengenai perkembangan COVID-19, baik berita positif maupun negatif. Munculnya berbagai berita ini berperan besar dalam memicu kecemasan, terutama berita yang bersifat negatif. Atas dasar hal tersebut, penelitian ini dilakukan dengan tujuan melihat pengaruh jenis berita perkembangan COVID-19 (positif, negatif, dan netral) terhadap tingkat kecemasan mahasiswa. Pendekatan metode eksperimental menggunakan rancangan simple randomized pretest-posttest design. Responden merupakan 75 mahasiswa (laki-laki=9, perempuan=66), dibagi menjadi kelompok eksperimen A (diberikan berita negatif, n= 26), kelompok eksperimen B (diberikan berita positif, n= 25) dan kelompok kontrol (diberikan berita netral, n= 24). Kecemasan responden diukur sebelum dan sesudah perlakuan menggunakan Coronavirus Anxiety Scale (CAS) dan Generalized Anxiety Disorder (GAD-7). Hasil uji one-way ANOVA menunjukkan bahwa tidak terdapat perbedaan selisih tingkat kecemasan yang signifikan antara kelompok eksperimen A, eksperimen B, dan kontrol (F(2)=0,1468, p>0,05). Tidak adanya perbedaan yang signifikan disebabkan oleh tidak munculnya setelah membaca berita. Emotional arousal tidak muncul dikarenakan pengalaman responden mendapatkan paparan berulang berita negatif sebelum penelitian dan karena perbedaan individu dalam pengalaman emotional arousal. Dengan demikian, dampak paparan berita negatif pada kesehatan mental tidak terlalu signifikan setelah pandemik COVID-19 dialami cukup lama.
Novel Technique for Confirmation of the Day of Ovulation and Prediction of Ovulation in Subsequent Cycles Using a Skin-Worn Sensor in a Population With Ovulatory Dysfunction: A Side-by-Side Comparison With Existing Basal Body Temperature Algorithm and Vaginal Core Body Temperature Algorithm
Authors: B. S. Hurst , K. Davies , R. C. Milnes , T. G. Knowles , A. Pirrie 
Published: March 2022

Objective: Determine the accuracy of a novel technique for confirmation of the day of ovulation and prediction of ovulation in subsequent cycles for the purpose of conception using a skin-worn sensor in a population with ovulatory dysfunction.Methods: A total of 80 participants recorded consecutive overnight temperatures using a skin-worn sensor at the same time as a commercially available vaginal sensor for a total of 205 reproductive cycles. The vaginal sensor and its associated algorithm were used to determine the day of ovulation, and the ovulation results obtained using the skin-worn sensor and its associated algorithm were assessed for comparative accuracy alongside a number of other statistical techniques, with a further assessment of the same skin-derived data by means of the “three over six” rule. A number of parameters were used to divide the data into separate comparative groups, and further secondary statistical analyses were performed.Results: The skin-worn sensor and its associated algorithm (together labeled “SWS”) were 66% accurate for determining the day of ovulation (±1 day) or the absence of ovulation and 90% accurate for determining the fertile window (ovulation day ±3 days) in the total study population in comparison to the results obtained from the vaginal sensor and its associated algorithm (together labeled “VS”).Conclusion: SWS is a useful tool for confirming the fertile window and absence of ovulation (anovulation) in a population with ovulatory dysfunction, both known and determined by means of the timing of ovulation. The body site where the skin-worn sensor was worn (arm or wrist) did not appear to affect the accuracy. Prior diagnosis of known causes of ovulatory dysfunction appeared to affect the accuracy to a lesser extent than those cycles grouped into late ovulation and “early and normal ovulation” groups. SWS is a potentially useful tool for predicting ovulation in subsequent cycles, with greater accuracy obtained for the “normal ovulation” group.
Effect of Long-Distance Running on Inter-segment Foot Kinematics and Ground Reaction Forces: A Preliminary Study
Authors: Li Jialin , Song Yang , Xuan Rongrong , Sun Dong , Teo Ee-Chon , Bíró István , Gu Yaodong 
Published: March 2022

Long-distance running has gained massive popularity in recent years, yet the intra-foot adaptations during this event remain unclear. This study aimed to examine the kinematic and ground reaction force alterations induced within the foot following a 5 and 10 km run using the Oxford Foot Model Ten marathon-experienced recreational runners participated in this study. Five-kilometer running led to more rearfoot dorsiflexion, rearfoot eversion, and rearfoot rotation while less forefoot plantarflexion during the stance phase. Increased rearfoot plantarflexion, while decreased forefoot plantarflexion, supination, adduction, and hallux plantarflexion were observed at 10 km. In addition, the forefoot space of footwear was found to play a role in hallux kinematics. Concerning GRFs, only a lesser propulsive force was presented after a 10 km run. Findings of this study showed that 5 km of running would induce excessive foot motion while 10 km of running may gradually change the foot posture and lead to reduced propulsive forces, which could potentially increase the risks of running-related injuries (RRI) due to overuse or fatigue. Nevertheless, further research is warranted, and this study could be used as a preliminary reference to evaluate and predict foot running-related injuries.
Long-Term Limitation Effects of Se(VI), Zn(II), and Ni(II) on Start-Up of the Anammox Process Using Gel Carrier
Authors: Isaka Kazuichi , Sugawara Daichi , Yamazaki Hiroshi , Kimura Yuya , Osaka Toshifumi , Tsuneda Satoshi 
Published: March 2022

Anaerobic ammonia oxidation (anammox) bacteria are inhibited by heavy metals at high concentrations but require trace amounts of some heavy-metal elements for growth and activity maintenance. The present study evaluates the long-term limitation effects of Se(VI), Zn(II), and Ni(II) on the start-up period of an anammox reactor. To strictly limit the levels of heavy metals in the reactor, all tests used ultrapure water as the influent synthetic wastewater and all reactors were installed in a clean booth. The anammox biomass was maintained through the gel entrapment technique. In the absence of Se(VI) and Ni(II), the anammox reactor start-up was 18.9 kg-N (m3-carrier d)−1 (nitrogen conversion rate (NCR) per gel carriers), indicating that Se(VI) and Ni(II) are not required or need not be continuously added to maintain the anammox process. Under Zn(II) limitation, the anammox process failed to start-up and the NCR tended to decrease rapidly. After readdition of 0.005 mg L−1 of Zn(II), the NCR did not decline further and instead partially recovered at a very slow rate. The NCR was completely recovered after adding 0.020 mg L−1 of Zn(II). These results reveal that Zn(II) limitation seriously affects the start-up of the anammox process while Se(VI) and Ni(II) are not required or need not be continuously added to the anammox process.
Liraglutide Lowers Palmitoleate Levels in Type 2 Diabetes. A Post Hoc Analysis of the LIRAFLAME Randomized Placebo-Controlled Trial
Authors: Wretlind Asger , Zobel Emilie Hein , de Zawadzki Andressa , Ripa Rasmus Sejersten , Curovic Viktor Rotbain , von Scholten Bernt Johan , Mattila Ismo Matias , Hansen Tine Willum , Kjær Andreas , Vestergaard Henrik , Rossing Peter , Legido-Quigley Cristina 
Published: March 2022

BackgroundLiraglutide is a glucose-lowering medication used to treat type 2 diabetes and obesity. It is a GLP-1 receptor agonist with downstream metabolic changes beyond the incretin system, such as reducing the risk of cardiovascular complications. The understanding of these changes is critical for improving treatment outcomes. Herein, we present a post hoc experimental analysis using metabolomic phenotyping to discover molecular mecphanisms in response to liraglutide.MethodPlasma samples were obtained from The LiraFlame Study (ClinicalTrials.gov identifier: NCT03449654), a randomized double-blinded placebo-controlled clinical trial, including 102 participants with type 2 diabetes randomized to either liraglutide or placebo treatment for 26 weeks. Mass spectrometry-based metabolomics analyses were carried out on samples from baseline and the end of the trial. Metabolites (n=114) were categorized into pathways and linear mixed models were constructed to evaluate the association between changes in metabolites and liraglutide treatment.ResultsWe found the free fatty acid palmitoleate was significantly reduced in the liraglutide group compared to placebo (adjusted for multiple testing p-value = 0.04). The activity of stearoyl-CoA desaturase-1 (SCD1), the rate limiting enzyme for converting palmitate into palmitoleate, was found significantly downregulated by liraglutide treatment compared to placebo (p-value = 0.01). These metabolic changes have demonstrated to be linked to insulin sensitivity and cardiovascular health.
Fermentative Lactic Acid Production From Lignocellulosic Feedstocks: From Source to Purified Product
Authors: Yankov Dragomir 
Published: March 2022

The second (lignocellulosic biomass and industrial wastes) and third (algal biomass) generation feedstocks gained substantial interest as a source of various value-added chemicals, produced by fermentation. Lactic acid is a valuable platform chemical with both traditional and newer applications in many industries. The successful fractionation, separation, and hydrolysis of lignocellulosic biomass result in sugars’ rich raw material for lactic acid fermentation. This review paper aims to summarize the investigations and progress in the last 5 years in lactic acid production from inexpensive and renewable resources. Different aspects are discussed—the type of raw materials, pretreatment and detoxification methods, lactic acid-producers (bacteria, fungi, and yeasts), use of genetically manipulated microorganisms, separation techniques, different approaches of process organization, as well as main challenges, and possible solutions for process optimization.
Impact of Early Feeding: Metagenomics Analysis of the Infant Gut Microbiome
Authors: Di Guglielmo Matthew D. , Franke Karl R. , Robbins Alan , Crowgey Erin L. 
Published: March 2022

BackgroundDifferent feeding regimens in infancy alter the gastrointestinal (gut) microbial environment. The fecal microbiota in turn influences gastrointestinal homeostasis including metabolism, immune function, and extra-/intra-intestinal signaling. Advances in next generation sequencing (NGS) have enhanced our ability to study the gut microbiome of breast-fed (BF) and formula-fed (FF) infants with a data-driven hypothesis approach.MethodsNext generation sequencing libraries were constructed from fecal samples of BF (n=24) and FF (n=10) infants and sequenced on an Illumina HiSeq 2500. Taxonomic classification of the NGS data was performed using the Sunbeam/Kraken pipeline and a functional analysis at the gene level was performed using publicly available algorithms, including BLAST, and custom scripts. Differentially represented genera, genes, and NCBI Clusters of Orthologous Genes (COG) were determined between cohorts using count data and R (statistical packages edgeR and DESeq2).ResultsThirty-nine genera were found to be differentially represented between the BF and FF cohorts (FDR ≤ 0.01) including Parabacteroides, Enterococcus, Haemophilus, Gardnerella, and Staphylococcus. A Welch t-test of the Shannon diversity index for BF and FF samples approached significance (p=0.061). Bray-Curtis and Jaccard distance analyses demonstrated clustering and overlap in each analysis. Sixty COGs were significantly overrepresented and those most significantly represented in BF vs. FF samples showed dichotomy of categories representing gene functions. Over 1,700 genes were found to be differentially represented (abundance) between the BF and FF cohorts.ConclusionsFecal samples analyzed from BF and FF infants demonstrated differences in microbiota genera. The BF cohort includes greater presence of beneficial genus Bifidobacterium. Several genes were identified as present at different abundances between cohorts indicating differences in functional pathways such as cellular defense mechanisms and carbohydrate metabolism influenced by feeding. Confirmation of gene level NGS data via PCR and electrophoresis analysis revealed distinct differences in gene abundances associated with important biologic pathways.
Are There Any Differences in the Prognostic Value of Left Ventricular Ejection Fraction in Coronary Artery Disease Patients With or Without Moderate and Severe Mitral Regurgitation?
Authors: Li Qiang , Zhang Yifei , Huang Haozhang , Chen Weihua , Shi Shanshan , Chen Shiqun , Wang Bo , Lai Wenguang , Huang Zhidong , Luo Zhiling , Chen Jiyan , Tan Ning , Liu Jin , Liu Yong 
Published: March 2022

BackgroundLeft ventricular ejection fraction (LVEF) is a vital variable to describe left ventricle systolic function and contractility of left ventricle. However, the association between LVEF and the prognostic effect in patients with moderate or severe mitral regurgitation (MR) is still controversial.MethodsThis study comprised 30,775 coronary artery disease (CAD) patients who underwent coronary arteriography (CAG) in the Cardiorenal ImprovemeNt (CIN) registry from January 2007 to December 2018. Patients were divided into none or mild MR group and moderate or severe MR group, and 3 levels of LVEF ≥50, 40–50%, and &lt;40% were further distinguished according to hospital baseline. Univariate and multivariate Cox proportional analyses were used to investigate the association between LVEF levels and long-term all-cause mortality in patients with different MR severities.ResultsOf 30,775 CAD patients (62.9 ± 10.6 years, females 23.8%), 26,474 (86.0%) patients had none or mild MR. Compared with none or mild MR patients, patients with moderate or severe MR were older and had worse cardio-renal function. In multivariable Cox proportional analysis, LVEF &lt;40% was independently associated with higher mortality compared with LVEF ≥ 50% in all kinds of MR severity {none or mild MR [adjusted hazard ratio (HR): 1.79; 95% CI: 1.56–2.05, p &lt; 0.001], moderate or severe MR [adjusted HR: 1.57; 95% CI: 1.29–1.91, p &lt; 0.001]}.ConclusionsLVEF is a reliable prognostic index in CAD patients, even in those with moderate or severe MR. LVEF monitoring would still be clinically useful in CAD patients with moderate or severe MR. Clinical trials are needed to prospectively evaluate the optimal threshold for LVEF in patients with moderate or severe MR.
Development and Validation of the Nomograms for Predicting Overall Survival and Cancer-Specific Survival in Patients With Synovial Sarcoma
Authors: Song Zhengqing , Cheng Lisha , Lu Lili , Lu Weiqi , Zhou Yuhong , Wang Zhiming 
Published: March 2022

BackgroundThe study aimed to build and validate practical nomograms to predict overall survival (OS) and cancer-specific survival (CSS) for patients with synovial sarcoma (SyS).MethodsA total of 893 eligible patients confirmed to have SyS between 2007 and 2015 were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were randomly divided into the training cohort (n = 448) and validation cohort (n = 445). Clinically independent prognostic and important factors were determined according to the Akaike information criterion in multivariate Cox regression models when developing the nomograms with the training cohort. The predictive accuracy of nomograms was bootstrapped validated internally and externally with the concordance index (C-index) and calibration curve. Decision curve analysis (DCA) was performed to compare the clinical usefulness between nomograms and American Joint Commission on Cancer (AJCC) staging system.ResultsTwo nomograms shared common indicators including age, insurance status, tumor site, tumor size, SEER stage, surgery, and radiation, while marital status and tumor site were only included into the OS nomogram. The C-index of nomograms for predicting OS and CSS was 0.819 (0.873–0.764) and 0.821 (0.876–0.766), respectively, suggesting satisfactory predictive performance. Internal and external calibration curves exhibited optimal agreement between the nomogram prediction and the actual survival. Additionally, DCA demonstrated that our nomograms had obvious superiority over the AJCC staging system with more clinical net benefits.ConclusionsTwo nomograms predicting 3- and 5-year OS and CSS of SyS patients were successfully constructed and validated for the first time, with higher predictive accuracy and clinical values than the AJCC staging system regarding OS and CSS.
Vitamin D Status and All-Cause Mortality in Patients With Type 2 Diabetes in China
Authors: Fan Yuxin , Ding Li , Zhang Yalan , Shu Hua , He Qing , Cui Jingqiu , Hu Gang , Liu Ming 
Published: March 2022

ObjectiveTo assess the association between vitamin D status and all-cause mortality among type 2 diabetes patients.Research Design and MethodsWe prospectively followed 1,291 participants with type 2 diabetes aged 20–80 years during 2013–2018. Cox proportional hazard regression models were used to estimate the association between different vitamin D status and all-cause mortality risk among hospitalized patients with type 2 diabetes.ResultsDuring a median follow-up of 4.15 years (5,365 person-years in total), 61 cases of death were identified. Multivariable-adjusted hazard ratios (HRs) for all-cause mortality across the quartiles of baseline circulating 25-hydroxy vitamin D (25-OH vitamin D) were 2.70 [95% confidence interval (CI) 1.12–6.54], 1.00, 1.39 (95% CI 0.53–3.65), 2.31 (95% CI 0.96–5.54), respectively. Multivariable-adjusted HRs for all-cause mortality by different groups of baseline 25-OH vitamin D concentrations (&lt;25, 25–49, 50–100, and ≥100 nmol/L) were 1.31 (95% CI 0.58–2.96), 0.94 (95% CI 0.47–1.87), 1.00, and 3.58 (95% CI 1.43–8.98), respectively.ConclusionsVery low or high concentrations of vitamin D may be associated with a higher risk of all-cause mortality among patients with type 2 diabetes.