bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Optimized Tuning of Pid Controller for Photonics and Optics Using Bio-Inspired Algorithm for Controlling Voltage and Current for Enhancement of Robustness
Authors: S Swaminathan , N.R Raajan 
Published: June 2022

Abstract
Optics and photonics are applied in vast range of application for information transmission between the Internet. In automated control system optics and photonics characteristics is important for automated processing. Automatic control demand for a vast range of applications such as food processing, aerospace and chemical industries. The issue with the automated control is the design of optimal controllers for off-line and on-line applications with reduced cost as the optics function. Renewable energy system gains the attention of the recent research for electricity generation especially in photovoltaic model robustness is major constraints. To mke use of the automated model for the photovoltaic system it needs to provide robustness. To achieve the desire robustness with minimized disturbance elimination physical and operating constraints need to be considered as multi-optics function. In this paper, developed a Multi-Optics Particle Swarm Optimization (MoPSO) algorithm for reduced complexity and improved ease of use. The proposed MoPSO provides the artificial intelligence-based metaheuristics approach for desire robustness in the PID controller. The designed MoPSO computation technique validated with the Phase Locked Loop system (PLL) and Magnetic Levitation System (MLS) for improved robustness in PID controller. The performance of proposed MoPSO is evaluated for the designed parameters to evaluate the output response. The measured output response of proposed MoPSO exhibits desire performance parameter for the RGA algorithm. The comparative analysis of the proposed MoPSO exhibits improved performance than the conventional PSO and DE. It is concluded that the design parameters of the proposed MoPSO is effective than the RGA and PSO.
Comparative Wavelet and MFCC Speech EmotionRecognition Experiments on the RAVDESS Dataset
Authors: Bajaj Aayush , Tripathi K.C. 
Published: June 2022

Abstract
Emotion Recognition (ER) from speech is one of the most interesting research domains for the scientific world. The challenge behind ER is essentially the method of speech-feature-extraction that can efficiently encapsulate speaker independent emotional information from speech signals. This paper compares the performance of Window-Fourier Transform Method, Mel-Frequency Cepstral Coefficients (MFCC’s) and Continuous/Discrete Wavelet Transforms from the perspective of constant vs variant localization of time-frequency on The Rayerson audio-visual database of emotional speech and song. Wavelet transform has proven to be a promising non-linear tool for signal analysis that has been successfully applied in image recognition, compression and other tasks. MFCC’s has been a standard in feature extraction for speech. The motive here is to compare both the methods using the Random Forest algorithm with similar hyperparameters.
Significance of postoperative serum carcinoembryonic antigen combined with tumor deposition in Stage II-III Colon Cancer Patients: a retrospective multicenter cohort study
Authors: Pu Hongjiang , Pang Xiaolin , Chen Yaxue , Ma Jianguo , Wu Runhong , Li Liyan , Liu Lizhu , You Ruimin , Fu Jiangping , Dong Xingxiang , Xiong Qiuxia 
Published: June 2022

Abstract
Purpose
This study aimed to investigate postoperative CEA combined with tumor deposition for risk stratification of postoperative recurrence of stage II-III colon cancer.
Methods
A retrospective analysis of 761 patients who underwent radical surgery for stage II-III colon cancer from April 2008 to January 2019. Patients were grouped into 3 cohorts: normal postoperative CEA without tumor deposits(TD), normal postoperative CEA with TD, and elevated postoperative CEA. Cox proportional hazards regression model was used to analyze the independent recurrence prognostic factors of patients with recurrence-free survival (RFS). The Kaplan-Meier method was used to draw the patient's RFS curve.
Results
The median follow-up period of all patients was 49.73 months. A total of 761 patients (452 [59.4%] male; median [IQR] age, 69 [50–67] years) were identified. The 3-year RFS of 60 patients with normal postoperative CEA and positive TD was 51.1% (95% CI, 39.8%-65.5%), and the 3-year RFS of 103 patients with elevated postoperative CEA was 47.7% (95% CI, 38.5%-58.3%). (Patients with normal postoperative CEA and positive TD vs Patients with elevated postoperative CEA: HR, 1.04; 95% CI, 0.67–1.60; P = 0.877). Multivariate analysis of the COX proportional hazards model showed that normal postoperative CEA with TD (HR, 2.0; 95% CI, 1.1–3.5) is independently associated with shorter RFS.
Conclusion
Patients with normal postoperative CEA still have a higher risk of recurrence if combined with tumor deposits. It is necessary to incorporate postoperative CEA and tumor deposition into high-risk factors for postoperative recurrence of colon cancer for management.
BDNFIV promoter methylation and antidepressant action: a complex interplay
Authors: Pathak Hansi , Borchert Anton , Garaali Sara , Burkert Alexandra , Frieling Helge 
Published: June 2022

Abstract
Background: BDNFIV promoter methylation is a potential biomarker for treatment response to antidepressants in MDD. We have previously shown CpG-87 methylation as a successful biomarker for prediction of non-response to monoaminergic antidepressants like the SSRI Fluoxetine or the SNRI Venlafaxine. This study aimed to dissect the biological evidence and mechanisms for functionality of CpG-87 methylation in a cell culture model.Results: We observed a significant interaction between methylation and antidepressant mediated transcriptional activity in BDNFIV promoter. In addition, antidepressant treatment increased the BDNFIV methylation in a concentration dependent manner. Further single CpG methylation of -87 did not change the promoter activity, but methylation of CREB domain CpG-39 increased the transcriptional activity in an antidepressant dependent manner. Interestingly, DNMT3a over-expression also increases the BDNFIV transcription and more so in Venlafaxine treated cells.Conclusions: The study strengthens the previously reported association between antidepressant treatment and BDNFIV methylation as well as hints towards the mechanism of action. We argue that potential CpG methylation biomarkers display a complex synergy with the molecular changes at the neighboring CpG positions, thus highlighting the importance of epiallele analyses.
Association of serum vitamin B levels with all-cause and cardiovascular mortality in hemodialysis patients
Authors: Wang Yan , Yang Bing , Zhu Li , Ni Meng-fan , Gan Liang-ying , Wang Mei , Zuo Li 
Published: June 2022

Abstract
Background: Patients on hemodialysis (HD) are prone to having vitamin B metabolic disorders, though impact of changes in serum vitamin B concentrations on patients’ survival remains unknown. This study is to investigate the association of serum vitamin B1, B3, B5, and B6 levels with all-cause mortality and cardiovascular mortality in HD patients.Methods: This is a prospective observational study conducted in the HD center of Peking University People's Hospital. At baseline, demographic and clinical characteristics of HD patients were collected, and pre-dialysis serum vitamin B1, B3, B5, and B6 levels were measured by high performance liquid chromatography- tandem mass spectrometry (HPLC-MS/MS) method. Patients were prospectively followed up for the occurrence of endpoint including all-cause and cardiovascular (CV) death. Survival curves were estimated by using Kaplan-Meier analysis. Cox proportional hazards regression analysis was used to examine the association of serum vitamin B1, B3, B5, and B6 with all-cause mortality and CV mortality.Results: Seventy-six HD patients were included. The incidences of vitamin B1, B3, B5, and B6 deficiencies were 86.8%, 23.7%, 97.4%, and 35.5%, respectively. The median follow-up time was 99(range 6 to 101) months. During follow-up, 28(36.8%) patients died, 19(25.0%) of them were due to CV diseases. Kaplan-Meier analysis showed that baseline vitamin B5＜69.0 nmol/l and vitamin B6＜8.1 ng/ml were associated with a higher risk of CV mortality (P=0.039 and 0.048). However, these associations were nullified after adjustment.Conclusions: Serum vitamin B1, B3, B5 and B6 concentrations were not associated with all-cause mortality or CV mortality in HD patients.
A Magnitude/Phase Bio-Impedance Measurement System with PWM Output
Authors: Zamani Milad , Rezaeiyan Yasser , Koolivand Yarallah , Moradi Farshad , Shoaei Omid 
Published: June 2022

Abstract
This paper presents an implantable bio-impedance device for long-term monitoring applications. The proposed magnitude/phase system includes a low-power analog front-end that generates pulse-width-modulated outputs. Additionally, the bio-impedance readout uses a Fibonacci DC-DC converter to convert voltage to time for backscattering communications. The proposed bio-impedance system is designed and simulated in a 0.18 µm CMOS process and occupies 200µm×170µm and measures bioimpedance at 2 kHz over a wide dynamic range of 100 Ω to 4 kΩ with 1.25 Ωrms accuracy while consuming just 4 µA from a 1.8 V supply.
The role of financial stress in mental health trajectories during COVID-19
Authors: Simonse Olaf , Dijk Wilco W. , Dillen Lotte F. , Dijk Eric 
Published: June 2022

Abstract
Using longitudinal data before and during the first six months of the pandemic for a representative sample of Dutch households, we examined the role of financial stress in mental health trajectories during the COVID-19 pandemic. Also, we examined possible relations of financial stress and mental health with households' income, financial buffers, and debts. The data revealed that average mental health did not change during the first six months of the pandemic but showed considerable underlying heterogeneity. Results showed that financial stress trajectories significantly explained the heterogeneity in mental health trajectories. While income did not explain financial stress, debts and insufficient buffers related to increased financial stress, which was in turn negatively related to mental health. We discuss the implications of our findings for mental health care and financial security policy and provide suggestions for future research.
Design and Analysis of an Inverted XY-3RPS Hybrid Mechanism for Polishing of Complex Surface
Authors: Song Xiaozong , Wang Xiaorong , Wang Jidong , Fu Haitao 
Published: June 2022

Aims:
An inverted XY-3-RPS hybrid mechanism was designed to apply ultraviolet-induced
nano-particle colloid jet machining to polish the complex surface.

Background:
The hybrid mechanism has been widely used in the ultra-precision polishing field for installing
different polishing tools on the moving platform to meet different machining requirements because
of its wide working space, good dynamic performance and large bearing capacity.

Objective:
The main objective of this study is to establish an inverted XY-3-RPS hybrid mechanism for
UV-induced nanoparticle colloid jet machining, to realize the ultra-precision polishing of complex surfaces
by UV-induced nanoparticle colloid jet machining.

Methods:
The three-dimensional model of the inverted XY-3-RPS hybrid mechanism was established,
and the kinematics and dynamics were analyzed. The Jacobian velocity matrix of the inverted XY-3-
RPS hybrid mechanism is derived by vector construction and differential methods, and the dexterity index
under different proportional parameters is optimized and simulated. The output Jacobian matrix and
stiffness matrix are obtained using the virtual work principle, and their static analysis is carried out.
Based on Lagrange dynamics theory, the dynamic mathematical model of the inverted XY-3-RPS hybrid
mechanism is established, and its kinematics is verified by software joint simulation. Through dynamic
simulation, the variation curves of motion, force and kinetic energy of the mechanism are obtained,
which provides a theoretical basis for applying the hybrid mechanism in complex curved surface
polishing.

Results:
The analysis shows that it has the best dexterity index when the ratio of moving and the fixed
platform is 2:1. The kinematic simulation results show that the hybrid mechanism moves reliably under
the given trajectory. The dynamic simulation results show that the force analysis of each kinematic pair
and the kinetic energy change curve of each part changes smoothly, and the dynamic performance is
stable under different trajectories.

Conclusion:
The parameter design and structural design of the inverted XY-3-RPS hybrid mechanism
meet the requirements of ultra-precision polishing of complex surfaces.
Assessment of the Anti-Malarial Properties of Dihydroartemisinin-
Piperaquine Phosphate Solid Lipid-Based Tablets
Authors: Amarachi Chime Salome , Attama Anthony Amaechi , Onunkwo Godswill Chukwunweike 
Published: June 2022

Background:
Artemisininbased combination therapies (ACTs) typified by dihydroartemisinin-
piperaquine phosphate are first-line drugs used in the treatment of
Plasmodium falciparum malaria. However, the emergence of drug resistance to ACTs
shows the necessity to develop novel sustained release treatments in order to ensure maximum
bioavailability.

Objectives:
To formulate dihydroartemisinin (DHA)-piperaquine phosphate (PQ) sustained
release tablets based on solidified reverse micellar solutions (SRMS).

Methods:
The SRMS was prepared by fusion using varying ratios of Phospholipon® 90H
and Softisan® 154 and characterised. The tablets were prepared by using an in-house
made and validated mould. The formulations were tested for uniformity of weight, hardness,
friability, softening time, erosion time and in vitro-in vivo dissolution rate. Antimalarial
properties were studied using modified Peter’s 4-days suppressive test in mice.
One-way analysis of variance (ANOVA) was used in the analysis of results.

Results:
Smooth caplets, with average weight of 1300 ± 0.06 mg to 1312 ± 0.11 mg,
drug content of 61 mg for DHA and t 450 mg for PQ. Tablet hardness ranged from 7.1 to
9.0 Kgf and softening time of 29.50 ± 1.90 min. Erosion time of 62.00 ± 2.58 to 152.00 ±
1.89 min were obtained for tablets formulated with Poloxamer 188 (Batches R2, S2 and
T2) which significantly reduced the softening and erosion time (p < 0.05). In vitro release
showed that the optimized formulations had a maximum release at 12 h. Formulations
exhibited significantly higher parasitaemia clearance and in vivo absorption compared
to marketed formulations at day 7 (p < 0.05).

Conclusion:
DHA-PQ tablets based on SRMS were much easier and relatively cheaper
to produce than compressed tablets. They also showed exceptionally better treatment of
malaria owing to their sustained release properties and improved bioavailability and are
recommended to Pharmaceutical companies for further studies.
Physicians’ Perceptions of Telemedicine Use During the COVID-19 Pandemic in Riyadh, Saudi Arabia: Cross-sectional Study
Authors: Idriss Sarah , Aldhuhayyan Abdullah , Alanazi Ahmad Abdullah , Alasaadi Walaa , Alharbi Reem , Alshahwan Ghadah , Baitalmal Mohammad , Alonazi Wadi 
Published: June 2022

Background
The term “telemedicine” refers to the use of communication technology to deliver health care remotely. The COVID-19 pandemic had substantial impacts on health care delivery from 2020 onward, and it was necessary to adapt high-quality care in a manner that limited the potential for viral exposure of both patients and health care workers. Physicians employed video, phone, and electronic written (e-consultation) visits, all of which provided quality of care comparable to that of face-to-face visits while reducing barriers of adopting telemedicine.

Objective
This study sought to assess physicians’ perspectives and attitudes regarding the use of telemedicine in Riyadh hospitals during the COVID-19 pandemic. The main objects of assessment were as follows: (1) physicians’ experience using telemedicine, (2) physicians’ willingness to use telemedicine in the future, (3) physicians’ perceptions of patient experiences, and (4) the influence of telemedicine on burnout.

Methods
This study employed SurveyMonkey to develop and distribute an anonymous 28-question cross-sectional survey among physicians across all specialty disciplines in Riyadh hospitals. A chi-square test was used to determine the level of association between variables, with significance set to P<.05.

Results
The survey was distributed among 500 physicians who experienced telemedicine between October 2021 and December 2021. A total of 362 doctors were included, of whom 28.7% (n=104) were consultants, 30.4% (n=110) were specialists, and 40.9% (n=148) were residents. Male doctors formed the majority 56.1% (n=203), and female doctors accounted for 43.9% (n=159). Overall, 34% (n=228) agreed or somewhat agreed that the “quality of care during telemedicine is comparable with that of face-to-face visits.” Approximately 70% (n=254) believed that telemedicine consultation is cost-effective. Regarding burnout, 4.1% (n=15), 7.5% (n=27), and 27.3% (n=99) of the doctors reported feeling burnout every day, a few times a week, and a few times per month, respectively.

Conclusions
The physicians had generally favorable attitudes toward telemedicine, believing that its quality of health care delivery is comparable to that of in-person care. However, further research is necessary to determine how physicians’ attitudes toward telemedicine have changed since the pandemic and how this virtual technology can be used to improve physicians’ professional and personal well-being.
Examining the Relationships Between Sleep Physiology and the Gut Microbiome in Preclinical and Translational Research: Protocol for a Scoping Review
Authors: Maki Katherine Anne , Alkhatib Jenna , Butera Gisela , Wallen Gwenyth Reid 
Published: June 2022

Background
Sleep is an instrumental behavioral state with evidence supporting its active role in brain function, metabolism, immune function, and cardiovascular systems. Research supports that there are pathways underlying the bidirectional communication between the brain and gastrointestinal system, also known as the “gut-brain axis.” Primary research examining sleep and gut microbiome relationships continues to increase. Although current data include both preclinical and clinical research, gut microbiome results are reported through a wide range of metrics (alpha diversity, beta diversity, and bacterial compositional changes), which makes cross-study comparison challenging. Therefore, a synthesis of the research examining sleep and gut microbiome relationships is necessary to understand the state of the science and address gaps in the literature for future research.

Objective
In this paper, we outline a scoping review protocol to evaluate and synthesize preclinical and clinical primary research focused on the associations between sleep and the gut microbiome.

Methods
The search strategy was facilitated through a medical research librarian and involved electronic databases including PubMed/MEDLINE, Embase, Scopus, Web of Science, CENTRAL trials database, BIOSIS Citation Index, and the Zoological Record. Gray literature sources including medRxiv and bioRxiv preprint servers were also searched. Studies were screened according to the aims and exclusion and inclusion criteria of the protocol. After screening, data will be extracted and synthesized from the included studies according to predefined sleep and microbiome methodology metrics.

Results
The search strategy yielded 4622 references that were imported for study screening, and source screening was completed in May 2022 by 2 independent investigators, resulting in a total of 93 sources for data extraction and synthesis. The data synthesis table is expected to be completed by August 2022, and the results will be disseminated through paper submission by December 2022 and presented at conferences related to neuroscience, sleep physiology, bioinformatics, and the microbiome.

Conclusions
A scoping review of preclinical and clinical research is needed to synthesize the growing data focused on the relationships between sleep and the gut microbiome. We expect the results of this synthesis will identify gaps in the literature and highlight pathways linking the gut-brain axis and sleep physiology to stimulate future research questions.

Trial Registration
Open Science Framework 69TBR; https://osf.io/69tbr

International Registered Report Identifier (IRRID)
PRR1-10.2196/38605
Dentro y Fuera del Ruedo
Authors: Chapa Benavides Martha , Ordorica Saavedra Alejandro , Iturriaga de la Fuente José N. 
Published: June 2022

<p style="text-align: justify;"><span>Martha Chapa Benavides, </span>Alejandro Ordorica Saavedra y José Iturriaga de la Fuente</p><p style="text-align: justify;">“Dentro y Fuera del Ruedo” es un libro basado en las perspectivas artísticas de la tauromaquia, a través de la percepción de una serie de espectadores totalmente externos a nuestras tradiciones y a nuestra cultura, naturalmente conocemos nuestro entorno y todo lo que conlleva ser mexicano, pero a partir de distintos puntos de vista y a través de los años las opiniones de esta antigua tradición han ido cambiando.</p><p style="text-align: justify;">Este título nos permitirá ver no solo una perspectiva diferente a la nuestra por parte de aquellos que se han dedicado a el análisis de este suceso, creará también una proyección de nuestras ideas más allá de la perspectiva general que se nos ha hecho ver, creo que será un libro bastante interesante si quieres abrir tus horizontes respecto a esta fiesta y conocer un poco del pensamiento extranjero sobre nuestro país y como es representado artísticamente de muchas formas.</p>
On the Completeness of Eigenfunctions of One 5th-Order Differential Operator
Authors: Rykhlov V. S. 
Published: June 2022

In this paper, we fully solve the problem of the completeness of the eigenfunctions of an ordinary 5th-order differential operator in the space of square-summable functions on the segment [0, 1] generated by the simplest differential expression \( y^{(5)} \) and two-point two-term boundary conditions \(\alpha_v y^{(v−1)}(0) + \beta_v
y^{(v−1)}(1) = 0\) and \(v =
\overline{1, 5}\), under the main assumption \(\alpha_v \ne 0\), \(v = \overline{1, 5}\) or \(\beta_v \ne 0\), \(v = \overline{1, 5}\) (in this case, without loss of generality, we can assume that all \(\alpha_v\) or all \(\beta_v\) , respectively, are equal to one). The classical methods of studying completeness, which go back to well-known articles by M. V. Keldysh, A. P. Khromov, A. A. Shkalikov, and many others, are not applicable to the operator under consideration. These methods are based on “good” estimates for the spectral parameter of the used generating functions (“classical”) for the system of eigenfunctions and associated functions. In the case of a strong irregularity of the operator under consideration, these «classical» generating functions have too large rate of grows in the spectral parameter. To solve the problem of multiple completeness, we propose a new approach that uses a special parametric solution that generalizes «classical» generating functions. The main idea of this approach is to select the parameters of this special solution to construct generating functions that are no longer «classical» with suitable estimates in terms of the spectral parameter. Such a selection for the operator under consideration turned out to be possible, although rather nontrivial, which allowed us to follow the traditional scheme of proving the completeness of the system of eigenfunctions in the space of square-summable functions on the segment [0, 1].