bluuebunny/crossref_metadata_2025_split huggingface dataset:
MARKETING DIGITAL EM MPE’S
Authors: Sotero do Vale Júnior João , Silva dos Santos Kleverson 
Published: August 2022

No ano de 2020, a internet torna-se uma ferramenta de sobrevivência para muitas pessoas no mundo, uma vez que a Pandemia da Covid-19 impossibilitou a liberdade do ir e vir da população e fechamento de estabelecimentos não essenciais. O artigo tem por objetivo analisar como o Instagram pode ser utilizado no marketing digital para melhorar a visibilidade das Micros e Pequenas Empresas (MPE’s). Como aportes teóricos tiveram em destaque Silva (2017), Costa (2018) e Kotler (2000). Para tanto, foi realizada uma pesquisa qualitativa, descritiva, do tipo analise sistemática do triênio de 2018-2020. O estudo mostrou que as Micros e Pequenas Empresas começaram a entender a importância e o conceito do marketing digital e de suas ferramentas, nesse caso em especifico no Instagram para sobrevivência no mercado.
Lateral Orbitofrontal Cortex and Basolateral Amygdala Regulate Sensitivity to Delayed Punishment during Decision-Making
Authors: Liley Anna E. , Gabriel Daniel B. K. , Simon Nicholas W. 
Published: August 2022

AbstractIn real-world decision-making scenarios, negative consequences do not always occur immediately after a choice. This delay between action and outcome drives the underestimation, or “delay discounting,” of punishment. While the neural substrates underlying sensitivity to immediate punishment have been well-studied, there has been minimal investigation of delayed consequences. Here, we assessed the role of lateral orbitofrontal cortex (LOFC) and basolateral amygdala (BLA), two regions implicated in cost/benefit decision-making, in sensitivity to delayed versus immediate punishment. The delayed punishment decision-making task (DPDT) was used to measure delay discounting of punishment in rodents. During DPDT, rats choose between a small, single-pellet reward and a large, three-pellet reward accompanied by a mild foot shock. As the task progresses, the shock is preceded by a delay that systematically increases or decreases throughout the session. We observed that rats avoid choices associated with immediate punishment, then shift preference toward these options when punishment is delayed. LOFC inactivation did not influence choice of rewards with immediate punishment, but decreased choice of delayed punishment. We also observed that BLA inactivation reduced choice of delayed punishment for ascending but not descending delays. Inactivation of either brain region produced comparable effects on decision-making in males and females, but there were sex differences observed in omissions and latency to make a choice. In summary, both LOFC and BLA contribute to the delay discounting of punishment and may serve as promising therapeutic targets to improve sensitivity to delayed punishment during decision-making.
The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells
Authors: López‐Haber Cynthia , Netting Daniel J , Hutchins Zachary , Ma Xianghui , Hamilton Kathryn E , Mantegazza Adriana R 
Published: August 2022

AbstractPhagocytosis is the necessary first step to sense foreign microbes or particles and enables activation of innate immune pathways such as inflammasomes. However, the molecular mechanisms underlying how phagosomes modulate inflammasome activity are not fully understood. We show that in murine dendritic cells (DCs), the lysosomal histidine/peptide solute carrier transporter SLC15A4, associated with human inflammatory disorders, is recruited to phagosomes and is required for optimal inflammasome activity after infectious or sterile stimuli. Dextran sodium sulfate‐treated SLC15A4‐deficient mice exhibit decreased colon inflammation, reduced IL‐1β production by intestinal DCs, and increased autophagy. Similarly, SLC15A4‐deficient DCs infected with Salmonella typhimurium show reduced caspase‐1 cleavage and IL‐1β production. This correlates with peripheral NLRC4 inflammasome assembly and increased autophagy. Overexpression of constitutively active mTORC1 rescues decreased IL‐1β levels and caspase1 cleavage, and restores perinuclear inflammasome positioning. Our findings support that SLC15A4 couples phagocytosis with inflammasome perinuclear assembly and inhibition of autophagy through phagosomal content sensing. Our data also reveal the previously unappreciated importance of mTORC1 signaling pathways to promote and sustain inflammasome activity.
Educación monocultural en la enseñanza de las artes visuales en contextos de diversidad cultural en Chile
Authors: Paz-Mardones Fernando , Kotthoff-Cristensen Francisco , Fuentes-Jara Freddy , Collipal-Velásquez Christian , Riquelme-Mella Enrique , Halberstadt Amy 
Published: August 2022

Introducción. El tema central del estudio es la incidencia que tiene la aplicación de un currículo monocultural en las concepciones de enseñanza de las artes visuales, y su impacto en los aprendizajes, la construcción de identidad cultural y el reconocimiento entre estudiantado mapuche y no mapuche. Objetivo. Develar las concepciones que tiene el profesorado en torno a la enseñanza de las artes visuales, su currículo y el contexto de diversidad cultural en zona pehuenche. Metodología. El enfoque metodológico es cualitativo de carácter exploratorio. Las personas participantes corresponden a siete profesores de artes visuales de enseñanza media en una zona Pehuenche de la región Araucanía de Chile, las técnicas de recolección de datos utilizadas fueron la entrevista semiestructurada y, el proceso de análisis fue de codificación abierta, axial y selectiva, con triangulación entre personas investigadoras y profesorado para apoyar la validez de los hallazgos. Resultados. Los principales resultados apuntan a la falta de conocimiento del personal docente sobre el contexto multicultural, sus deficiencias en la formación inicial y el problema general de la relación existente entre un currículo monocultural y su efecto sobre sus creencias sobre la enseñanza de artes visuales en el contexto de diversidad cultural. Conclusiones. La creencia del personal docente de artes visuales es afectada por el currículo de carácter monocultural, al presentar relaciones con la estandarización y la valoración negativa de este. Además, el currículo condiciona la formación inicial docente, estandarizándola, sin considerar las variables contextuales.
Análisis de la evolución los libros de texto de educación primaria desde una perspectiva crítica: Estudio del repertorio musical desde 1994 hasta 2019
Authors: Marín-Liébana Pablo , Blasco-Magraner José Salvador , Botella-Nicolás Ana María 
Published: August 2022

Introducción. Los libros de texto constituyen uno de los principales objetos de estudio de la historia de la educación en tanto que depositarios de la ideología del grupo del que emanan y reflejo de los significados que configuran la cultura escolar. Por otra parte, los movimientos de pedagogía musical crítica apuestan por la utilización de un repertorio vinculado a las identidades y preferencias musicales del estudiantado. Desde esta perspectiva, este artículo de investigación presenta un estudio sobre la evolución del repertorio musical en los libros de texto de música en educación primaria en la provincia de Valencia desde 1994 hasta 2019. Metodología. Se han analizado 1121 piezas musicales pertenecientes a 18 manuales mediante el análisis de contenidos. Resultados. Los resultados indican una tendencia hacia una mayor diversidad musical, aunque con un predominio de la música clásico-romántica y folklórico-tradicional y una escasa representación de la música popular urbana. Discusión. La progresiva inclusión de música popular urbana en los libros de texto podría servir para reconocer y dar voz a las identidades musicales del estudiantado. No obstante, dicho repertorio es muy heterogéneo y no necesariamente tiene que incluir las preferencias musicales actuales.
Decreasing Time to Full Enteral Feeds in Hospitalized Children With Medical Complexity Experiencing Feeding Intolerance
Authors: Musial Abigail , Schondelmeyer Amanda , Densel Owen , Younts Angela , Kelley Jodi , Herbst Lori , Statile Angela M. 
Published: August 2022

BACKGROUND AND OBJECTIVES
Children with medical complexity (CMC) with gastrostomy and jejunostomy tubes are commonly hospitalized with feeding intolerance, or the inability to achieve target enteral intake combined with symptoms consistent with gastrointestinal dysfunction. Challenges resuming feeds may prolong length of stay (LOS). Our objective was to decrease median time to reach goal feeds from 3.5 days to 2.5 days in hospitalized CMC with feeding intolerance.

METHODS
A multidisciplinary team conducted this single-center quality improvement project. Key drivers included: standardized approach to feeding intolerance, parental buy-in and shared understanding of parental goals, timely formula delivery, and provider knowledge. Plan-do-study-act cycles included development of a feeding algorithm, provider education, near–real-time reminders and feedback. A run chart tracked the effect of interventions on median time to goal enteral feeds and median LOS.

RESULTS
There were 225 patient encounters. The most common cooccurring diagnoses were viral gastroenteritis, upper respiratory infections, and urinary tract infections. Median time to goal enteral feeds for CMC fed via gastrostomy or gastrojejunostomy tubes decreased from 3.5 days to 2.5 days within 6 months and was sustained for 1 year. This change coincided with implementation of a feeding intolerance management algorithm and provider education. There was no change in LOS.

CONCLUSIONS
Implementation of a standardized feeding intolerance algorithm for hospitalized CMC was associated with decreasing time to goal enteral feeds. Future work will include incorporating the algorithm into electronic health record order sets and spread of the algorithm to other services who care for CMC.
Annual and seasonal trends in cow's milk quality determined by FT-MIR spectroscopy in Hungary between 2011 and 2020
Authors: Kocsis Róbert , Süle Judit , Nagy Péter , Gál Judit , Tardy Emília , Császár Gábor , Rácz Bence 
Published: August 2022

Abstract
We analysed and monitored the major chemical composition of cow's bulk milk by Fourier transform mid-infrared (FT-MIR) spectroscopy over a 10-year period in the whole territory of Hungary. In addition, the two most important key parameters for milk quality assessment, total bacterial count (TBC) and somatic cell count (SCC) were also followed. Production parameters showed significant seasonal and yearly changes. The overall mean fat, protein, lactose and solids-non-fat (SNF) contents of cow's milk were 3.81%, 3.32%, 4.74% and 8.76%, respectively. A circannual variation was observed in the chemical composition and yield of milk components of samples examined between 2011 and 2020. Concerning milk fat, milk protein and SNF, the values were the lowest in summer and the highest in winter. In the case of lactose, the minimum values were measured in autumn and the maximum values in spring. An obvious trend of long-term elevation of lactose and SNF was found in the raw cow milk samples over the observed period. The overall mean TBC and SCC of cow's milk were 52 × 103 CFU ml−1 and 270 × 103 cells/ml, respectively. Although there were differences in the monthly average values, no seasonal cyclicality was observed.
Biomechanical testing of canine tibiae: Changes resulting from different tibial tuberosity advancement techniques – Pilot study
Authors: Zólyomi Dorottya , Ipolyi Tamás , Molnár Péter , Németh Tibor , Faragó Dénes , Kiss Rita , Szalay Ferenc 
Published: August 2022

Abstract
The objective of the present pilot study was to determine the force required to break (a) intact canine tibiae, (b) tibiae following the osteotomy of the tibial tuberosity and (c) tibiae following Tibial Tuberosity Advancement- (TTA-) rapid surgery. Six pairs of tibiae of dogs between 15 and 35 kg body weight were used in a cadaver study. Three groups were created with four tibiae in each group; intact (Group 1), osteotomy of the tibial tuberosity and tibial crest (Group 2) and TTA-rapid (Group 3). The tibiae were put under static axial compressive load, applied until failure. The force required to break the tibiae was termed maximal force (F
max). The mean of F
max was 8193.25 ± 2082.84 N in Group 1, 6868.58 ± 1950.44 N in Group 2 and 7169.71 ± 4450.39 N in Group 3. The sample size was small for a statistical analysis but as a preliminary result, we have determined the force (F
max) required to break canine tibiae. Furthermore, we hypothesise that osteotomies result in weakening of the tibial structure.
Mucopolysaccharidosis VI in a European Shorthair cat: Neurological presentation, computed tomography findings and genetic investigation
Authors: Bravaccini Beatrice , Buffagni Valentina , Negro Linda , Bertolini Giovanna , Burbaite Evelina , Menchetti Marika 
Published: August 2022

Abstract
The present case report describes the clinical signs of a 10-month-old, intact female, Domestic Shorthair cat presented with a history of chronic progressive difficulty to walk with the four limbs. The physical and neurological examinations revealed skeletal deformities, corneal opacity and a severe spastic non-ambulatory tetraparesis. Complete blood count and biochemistry profiles were unremarkable. Diffuse bone rarefaction, hyperostosis and an apparent fusion of the vertebral bodies were observed on spinal radiographs. A non-contrast computed tomography (CT) exam of the whole body of the patient was performed. Based on the medical history, clinical findings, laboratory analysis, spinal radiographs and CT findings, a lysosomal storage disorder was suspected. Genetic testing for mucopolysaccharidosis VI and VII revealed a genetic mutation, ARSB variant L476P, confirming the diagnosis of mucopolysaccharidosis type VI.
Testing the antigenotoxicity and anticytotoxicity properties of Prunella Grandiflora L. extract using the example of Drosophila Melanogaster
Authors: Magombe Ngonidzaishe , Kostenko Viktoria V. , Antosyuk Olga N. , Bolotnik Elizaveta V. 
Published: August 2022

Using the Drosophila melanogaster model object, the presence of protective properties in 10% of Prunella grandiflora L. (Lamiaceae) extract was determined in relation to the toxic and cytotoxic effects of the antitumor drug etoposide in two concentrations of 800 and 8000 µg/kg of nutrient medium. The grass P. grandiflora was collected in the flowering phase in Sverdlovsk region (N 56°09'22.0'', E 058°32'19.6'') in 2021. No genotoxic manifestations of the extract were found. Comparative characteristics of wing parameters under the influence of etoposide at a dose of 800 and 8000 mg showed significant differences in linear and two-dimensional parameters of the wing.
Effect of cooling rate on the structure and electrochemical properties of Mn-based oxyfluorides with cation-disordered rock-salt structure
Authors: Mishchenko Kseniya V. , Kirsanova Maria A. , Slobodyuk Arseny B. , Krinitsyna Anna A. , Kosova Nina V. 
Published: August 2022

According to the extensive studies in the field of high-energy cathode materials for lithium-ion batteries (LIBs), Mn-based oxyfluorides Li1.2Mn0.6+0.5yNb0.2–0.5yO2–yFy with Li-excess and cation-disordered rock-salt structure capable of reversible cationic and anionic redox reactions are among the most promising candidates. In this work, a series of Mn-based oxyfluorides with y = 0.05, 0.10, 0.15 were obtained using mechanochemically assisted solid-state synthesis with different cooling rates. Transmission electron microscopy, electron paramagnetic spectroscopy (EPR) and nuclear magnetic resonance spectroscopy (NMR) show that increasing the amount of fluorine promotes local ordering in crystals with the formation of isolated clusters of Mn3+–O2––Mn4+ that interrupt lithium diffusion. The occurrence of local ordering depends on the conditions of synthesis and affects electrochemistry. It was found that more clusters are formed in slowly cooled samples than in quenched ones. The best electrochemical characteristics with reversible capacity of 150 mAh·g–1 at room temperature were demonstrated by the Li1.2Mn0.65Nb0.15O0.90F0.10 sample obtained by quenching.
Electrochemical behavior of chloramphenicol on carbon electrodes in a microelectrochemical cell
Authors: Svalova Tatiana S. , Zaidullina Regina A. , Medvedeva Margarita V. , Vedernikova Elizaveta D. , Kozitsina Alisa N. 
Published: August 2022

Express determination of antibiotics is an extremely important task today. Portable electrochemical microdevices are a viable alternative to traditional methods of analysis. The development of such devices requires the study of redox processes in detail. This article is devoted to the comparative study of the electrochemical behavior of chloramphenicol in water solvents in standard laboratory and portable microelectrochemical cells. It was found that the electrochemical reduction of chloramphenicol proceeds via a 3-electron mechanism to the formation of a dimer. In the transition from the macrocell to the microcell, a decrease in the electrochemical reduction current and a shift of the peak potential to the cathode region are observed, which is apparently associated mainly with the type of the electrode material. The best characteristics of the direct electrochemical response were obtained in the differential pulse voltammetry mode. Under the selected operating parameters, the peak current of the electrochemical reduction of chloramphenicol is linearly dependent on the concentration of the antibiotic in the range of 2∙10–3–1∙10–5 M with a detection limit of 3∙10–5 M. Obtained characteristics are sufficient for the quality control of pharmaceuticals and can be improved through the use of organic and hybrid modifiers of the working electrode surface.
PENGALAMAN SISWA TENTANG PENDIDIKAN SEKS SELAMA MASA PANDEMI SERTA PERAN GURU BIMBINGAN KONSELING
Authors: Lessy Ruri Anita , Diniaty Amirah 
Published: August 2022

This research aimed at knowing 1) students' experiences of sex education during the pandemic, 2) the role of guidance and counseling teachers in providing sex education to students during the pandemic, 3) supporting and obstructing factors the successful implementing counseling services regarding to sex education at State Senior High School 10 Pekanbaru. It was a descriptive qualitative. The main informants of this research were 4 guidance and counseling teachers and 10 students. The object of this research was the role of guidance and counseling teachers in providing sex education to students during the pandemic period. Interview and documentation techniques were used for collecting the data. Data analysis using data reduction, data presentation, and drawing conclusions. The findings of this research showed that students got experiences about sex education from online media. The Information obtained by students related to reproductive organs, sexual orientation, sexual deviation, and sexual crimes. Students stated that they needed guidance from the guidance and counseling teachers in understanding sex education. On the other hand, guidance and counseling teachers did not play active roles in providing sex education to students during the pandemic, this is due to limited time. The supporting factors in implementing sex education services were that the experience of guidance and counseling teachers, collaboration with various parties, facilities and infrastructure, and interesting material. The obstructing factors in implementing sex education services were that the educational background of guidance and counseling teachers, the pandemic and limited time, the lack of students interest to consult, the students’ personality and desire to change and the use of media, the views on sex education that was taboo and also the use of proper grammar. The findings of this research were suggested that special attention was needed from guidance and counseling teachers and parents in guiding students to understand sex education.
ОСОБЕННОСТИ ОПРЕДЕЛЕНИЯ АНИЗОТРОПНЫХ ПАРАМЕТРОВ ПО РЕЗУЛЬТАТАМ ТРАССЕРНЫХ ИССЛЕДОВАНИЙ ПЛАСТА Ю11 НА ПРИМЕРЕ НЕФТЯНОГО МЕСТОРОЖДЕНИЯ
Authors: Коровин Михаил Олегович 
Published: August 2022

Актуальность исследования состоит в необходимости поддержания добычи нефти на высоком уровне. Наращивание сырьевой базы является важным фактором финансирования налоговой базы региона. Нефть – невозобновляемый источник энергии, поэтому человечество не может позволить себе нерационально его использовать. У нефти есть немаловажный фактор высокой теплоты сгорания, и этот параметр выгодно отличает ее от остальных источников энергии. Из нефти производится огромный спектр продуктов, не говоря уже об использовании нефтепродуктов в двигателях внутреннего сгорания. И спрос на нефть, несмотря на разработки в области возобновляемых источников энергии, продолжает расти. Для увеличения коэффициента извлечения нефти требуется выбрать наиболее эффективную стратегию разработки месторождения, которая позволит снизить остаточные запасы. Выбор стратегии разработки основывается на результатах расчёта гидродинамических моделей. Цель данной работы – определение параметров анизотропии проницаемости в пласте Ю11 по результатам анализа трассерных исследований. На нижележащем пласте Ю13 аналогичные исследования проведены. Необходимо проверить, возможно ли пользоваться той же методикой анализа трассерных исследований для исследуемого пласта или её нужно изменить. Объект исследования – верхнеюрские терригенные отложения одного из месторождений на территории Томской области. Методы. Анализ трассерных исследований приводит к решению важной задачи определения параметров фильтрационной неоднородности и к ответу на вопросы о едином подходе расчёта параметров неоднородности по разным пластам и сопоставимости полученных результатов с распределением характеристик анизотропии по геофизическим исследованиям скважин. Методика подразумевает определение количества индикаторной жидкости, перемещённой от нагнетательных к добывающим скважинам. Дополнительно анализируется проницаемость и создаются розы-диаграммы распределения параметров. Используется ранее опробованный метод пространственного распределения параметров по геофизическим исследованиям скважин. Трассерные исследования применяются для проверки достоверности расчётов по каротажным данным. В результате расчётов и исследований получилось с помощью анализа трассерных исследований подтвердить параметры анизотропии, полученные по результатам ГИС. Получились очень близкие значения параметров. Анализ трассерных исследований показал, что использование технологии определения и учёта анизотропии проницаемости, ранее применявшейся на нижележащем пласте Ю13, отражает достоверные результаты для терригенного пласта Ю11. Полученные данные отражают направление неоднородности проницаемости, учитывая распределение индикаторной жидкости от нагнетальных скважин к добывающим. Также величины, полученные с помощью анализа геофизических исследований скважин, подтверждаются данными трассерных исследований.