bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse drug reaction of antiepileptic monotherapy on epileptic paediatric patients in Dr Sardjito Hospital, Yogyakarta, Indonesia
Authors: Harjaningsih Woro , Rahmania Emma , Firdha Sheila Nabila 
Published: March 2022

Introduction: Epilepsy is a neurological disease with the highest prevalence in paediatrics. Using anti-epileptic drug as monotherapy is the first-line therapy for paediatrics based on risk-benefit ratio consideration in the patients effectiveness and adverse drug reaction of anti-epileptic monotherapy drug for the cognitive function in paediatric patients.
Objectives: The aim of the study is to assess effectivity and adverse drug reaction of anti-epileptic monotherapy drug for the cognitive function in
paediatric patients.
Methods: This was a cross sectional study. This study used patients from the Dr. Sardjito hospital’s outpatient paediatric unit’s Neurology division from May to July 2013 and May to June 2019 to select the subjects. Patient questionnaires and medical records provided the data that was used. Effectiveness was assessed by seizure severity with Hague Seizure Severity Scale (HASSS) questionnaire and seizure frequency, while adverse drug reactions in cognitive function were assessed by the PESQ (Pediatric Epilepsy Side Effect Questionnaire) instrument.
Results: In total, 29 patients received monotherapy, with 26 patients (89.66%) receiving valproate, two (6.89%) receiving phenytoin, and one (3.45%) receiving phenobarbital. A total 89.66% of patients did not have severe seizures, but 6.90% had moderate seizures. The cognitive function of epileptic patients with co-morbidities receiving valproate monotherapy had moderate (27.59%) and severe (20.69%) side effects. The adverse drug reaction experienced in epileptic patients without co-morbidities using valproate was with the cognitive function, with 6.89% of patients experiencing severe effects, 13.79% moderate and 20.69% mild effects.
Conclusion: While anti-epileptic monotherapy can control seizures in children, the commonly prescribed valproate can impair cognitive function, especially in those with co-morbidities.
White Turmeric (Kaempferia rotunda L.) extract liquid soap preparation for feminine hygiene and effectiveness against Candida albicans
Authors: Stiani Sofi Nurmay , Putri Lila Ardiani , Yusransyah  , Indriatmoko Dimas Danang 
Published: March 2022

Background: Kaempferia rotunda L. (white turmeric) contains alkaloids, phenols, saponins, glycosides, steroids, terpenoids, and other ingredients with antimicrobial, anticancer, antiallergic, antioxidant, analgesic, and antifungal properties. Meanwhile, vaginal discharge or fluor albus is an excessive release of non-bloody fluid caused by the Candida albicans fungus.
Objective: This study aimed to formulate white turmeric extracts (Kaempferia rotunda L.) into standard liquid soap for feminine hygiene and to determine the level of antifungal activity against Candida albicans.
Methods: The liquid soap was produced by the maceration of white turmeric in 70% ethanol, which was evaporated until a thick extract was formed. This soap preparation included 7% stearic acid, 1% adeps lanae, 2% triethanolamine (TEA), 5% glycerol, white turmeric extract (at concentrations of 20%, 25%, and 30%), vanilla oil, and distilled water added up to 100 mL. Furthermore, the well method was used to test the antifungal activity of the preparations, and analysis was done on SPSS.
Results: The results showed that the white turmeric ethanol extract was effective against the Candida albicans fungus at concentrations of 25% and 30%, with inhibitory diameters of 11 mm and 15 mm (categorised as powerful), respectively. Also, the liquid soap preparations of the extract revealed antifungal activity at a concentration of 30%, with a 9.6 mm inhibition diameter (medium category). The soap met Indonesian National Standard (SNI) requirements, including organoleptic, pH, high foam, and viscosity properties.
Conclusion: The white turmeric ethanol extract can be formulated into a feminine hygiene soap with antifungal activity at a concentration of 30%.
EFEKTIVITAS PEMBELAJARAN BIOLOGI MELALUI MODEL ARGUMENT DRIVEN INQUIRY TERHADAP KETERAMPILAN BERARGUMENTASI DAN HASIL BELAJAR SISWA
Authors: Mutiah Haerul , Ulfa Andi Yurni 
Published: March 2022

Penelitian ini bertujuan untuk mengetahui efektivitas model pembelajaran Argument Driven Inquiry terhadap hasil belajar dan keterampilan berargumentasi siswa sebagai salah satu aspek penting dalam keterampilan proses sains. Jenis penelitian yang digunakan adalah Quasi Experimental (penelitian semu) dengan desain penelitian nonequivalent control group design. Hasil analisis menunjukkan bahwa keterampilan berargumentasi siswa pada kelas eksperimen jauh lebih tingi dibandingkan dengan siswa di kelas kontrol hal ini dibuktikan dengan masih terdapat 24% siswa di kelas kontrol yang belum mampu berargumen dengan baik sementara di kelas eksperimen hanya sekitar 4%. Hasil belajar Biologi yang diajar dengan model Argument Driven Inquiry (ADI) pada kelas eksperimen diperoleh rata-rata pretest 44,24 dengan kategori rendah sedangkan rata-rata nilai posttestnya yaitu 78,12 dengan kategori tinggi. Hasil belajar Biologi siswa yang diajar dengan model Non-ADI (kelas kontrol) diperoleh rata-rata nilai pretest sebesar 45,88 yang berada pada kategori rendah, sedangkan nilai posttestnya yaitu 68,16 dengan kategori cukup. Berdasarkan hasil analisis diperoleh nilai thitung= 2,03 > ttabel =0,03. Dari data tersebut ditarik kesimpulan bahwa terdapat perbedaan yang signifikan antara rata-rata hasil belajar Biologi dan keterampilan berargumentasi siswa kelas eksperimen dan kelas kontrol. Hasil ini mengindikasikan bahwamodel pembelajaran Argument Driven Inquiry sangat efektif dalam mengembangkan keterampilan argumentasi siswa.
Impact of I-GWO towards Trust based Resource Allocation in Collaborative Cloud
Authors: Pol Pooja , Pachghare Dr. Vinod K. 
Published: April 2022

The cloud computing is arising as a popular computing paradigm, as it is good in offering its users an on-demand scalable resource based services over the internet. In the peak hours, a single cloud is not at all efficient in serving an application; therefore the collaborative cloud model has been introduced. The collaborative cloud computing (CCC) make use of the globally-scattered distributed cloud resources of the diverse organizations collectively in a co-operative manner to provide the required service to the user. The allocation as well as the management of the resources is being a challenging task in the CCC, due to the heterogeneity of the resources. On the other hand, the assurance of the Quality of Service (QoS) and reliability of these resources is challenging. Further, it would be efficient if the resources are provided based on the system behavior. In this research work, a novel trust computing model is developed, which predicts both the QoS and Trust via analyzing the system behavior. The proposed model encloses three major phases: trust- QoS behavior estimation, resource matching and resource allocation. Initially, the QoS as well as Trust behavior of the system is estimated via a Neural Network (NN) model. Subsequently, the resource allocation is performed using the parallel resource matching framework, which is based on the concept of Map-Reduce. More particularly, the precious resource allocation is achieved by an optimization logic called Improved Grey Wolf Optimizer (IGWO). Here, the improvement of GWO emphasis the consideration of both the best and worst fitness.
Closed ideals in the functionally countable subalgebra of C(X)
Authors: Veisi Amir 
Published: April 2022

In this paper, closed ideals in Cc(X), the functionally countable subalgebra of C(X), with the mc-topology, is studied. We show that ifX is CUC-space, then C*c(X) with the uniform norm-topology is a Banach algebra. Closed ideals in Cc(X) as a modified countable analogue of closed ideals in C(X) with the m-topology are characterized. For a zero-dimensional space X, we show that a proper ideal in Cc(X) is closed if and only if it is an intersection of maximal ideals of Cc(X). It is also shown that every ideal in Cc(X) with the mc-topology is closed if and only if X is a P-space if and only if every ideal in C(X) with the m-topology is closed. Moreover, for a strongly zero-dimensional space X, it is proved that a properly closed ideal in C*c(X) is an intersection of maximal ideals of C*c(X) if and only if X is pseudo compact. Finally, we show that if X is a P-space and F is an ec-filter on X, then F is an ec-ultrafilter if and only if it is a zc-ultrafilter.
Validity and reliability of the Egyptian algometer in patients with bruxism
Authors: Ibrahim Mostafa M. , El-Gendy Mohamed H. , Helmy Emad S. , A. Hamada Hamada , Neamat Allah Neama H. 
Published: March 2022

IntroductionPressure pain threshold has been quantified by using a gold standard algometer in patients with bruxism. However, the expense associated with quantifying pressure pain threshold to detect trigger points with a gold standard algometer precludes its use in the clinic. This study aimed to measure the reliability and validity of the more accessible Egyptian algometer for pressure pain threshold evaluation in patients with bruxism.MethodsA descriptive repeated-measures study was performed among 100 participants with bruxism. Pressure pain threshold values were collected from the left temporalis, right temporalis, left masseter, and right masseter muscles with the participants sitting. Pressure pain thresholds were assessed over 2 sessions separated by a 1-week interval.ResultsIntraclass correlation coefficient (ICC) determined the intra-rater reliability and Pearson correlation analysis determined the validity of the Egyptian algometer. ICC equalled 0.878, 0.785, 0.896, and 0.903 for the right masseter, left masseter, right temporalis, and left temporalis muscles, respectively. The standard error of measurement ranged from 0.24 to 0.5, the minimal detectable difference ranged from 0.66 to 1.41, ICC ranged from 0.785 to 0.903. Pearson correlation values were 0.673, 0.670, 0.408, and 0.705 for the right masseter, left masseter, right temporalis, and left temporalis muscles, respectively.ConclusionsHigh ICCs indicated a strong agreement between the measurement systems, suggesting that the Egyptian algometer is a reliable and valid device for quantification of pressure pain threshold in patients with bruxism.
Bivalent metal complexes of a novel modified nicotinic acid hydrazide drug: Synthesis, characterization, and anti-tubercular studies
Authors: Mikwa Cyprian Chunkang , Toh-Boyo Gwendoline Mochia , Njong Romanus Nyako , Ndoye Bridget Ndosiri , Ndamyabera Christophe Adrien , Katsuumi Natsuki , Mitani Yuta , Nfor Emmanuel Ngwang , Akitsu Takashiro 
Published: March 2022

Iron(II) and manganese(II) complexes of N'-(1-(pyridin-2-yl)ethylidene)nicotinohydrazide (LH) have been synthesized and characterized by elemental analysis, IR, and 1H NMR spectroscopy. The crystal structure of the ligand has been determined by single crystal X-ray diffraction and electronic spectroscopic techniques. Crystal data for LH, C13H12N4O: Orthorhombic, space group Pbcn (no. 60), a = 18.0824(3) Å, b = 7.86555(14) Å, c = 16.1614(3) Å, V = 2298.60(7) Å3, Z = 8, T = 103 K, μ(Mo Kα) = 0.093 mm-1, Dcalc = 1.388 g/cm3, 36729 reflections measured (5.042° ≤ 2Θ ≤ 54.966°), 2633 unique (Rint = 0.0224, Rsigma = 0.0124) which were used in all calculations. The final R1 was 0.0383 (F2>2σ(F2)) and wR2 was 0.0988 (all data). The ligand was found to chelate to the metal ions through the azomethine nitrogen and amide oxygen atoms in a bidentate manner. The anti-tubercular activity of the ligand, its iron (II) and manganese (II) complexes were studied against Mycobacterium tuberculosis (ATTC 27294). The results revealed higher activity of the iron (II) complex with MIC value of 8.00±0.83 µM and a moderate activity of the manganese (II) complex having MIC value of 14.20±1.40 µM, compared to the reference drugs having MIC values of 9.41±0.92, 10.74±1.02, 25.34±2.6 µM and parent ligand with MIC value of 17.60±1.80 µM.
Radiative and microphysical responses of clouds to an anomalous increase in fire particles over the Maritime Continent in 2015
Authors: Takeishi Azusa , Wang Chien 
Published: March 2022

Abstract. The year of 2015 was an extremely dry year for Southeast Asia where the direct impact of a strong El Niño was in play. As a result of this dryness and the relative lack of rainfall, an extraordinary quantity of aerosol particles from biomass burning remained in the atmosphere over the Maritime Continent during the fire season. This study uses the Weather Research and Forecasting model coupled with Chemistry to understand the impacts of these fire particles on cloud microphysics and radiation during the peak biomass burning season in September. Our simulations, one with fire particles and the other without them, cover the entire Maritime Continent region at a cloud-resolving resolution (4 km) for the entire month of September in 2015. The comparison of the simulations shows a clear sign of precipitation enhancement by fire particles through microphysical effects; smaller cloud droplets remain longer in the atmosphere to later form ice crystals, and/or they are more easily collected by ice-phase hydrometeors in comparison to droplets under no fire influences. As a result, the mass of ice-phase hydrometeors increases in the simulation with fire particles, and so does rainfall. On the other hand, the aerosol radiative effect weakly counteracts the invigoration of convection. Clouds are more reflective in the simulation with fire particles as ice mass increases. Combined with the direct scattering of sunlight by aerosols, the simulation with fire particles shows higher albedo over the simulation domain on average. The simulated response of clouds to fire particles in our simulations clearly differs from what was presented by two previous studies that modeled aerosol–cloud interaction in years with different phases of El Niño–Southern Oscillation (ENSO), suggesting a further need for an investigation on the possible modulation of fire–aerosol–convection interaction by ENSO.
Biogeochemical functioning of the Baltic Sea
Authors: Kuliński Karol , Rehder Gregor , Asmala Eero , Bartosova Alena , Carstensen Jacob , Gustafsson Bo , Hall Per O. J. , Humborg Christoph , Jilbert Tom , Jürgens Klaus , Meier H. E. Markus , Müller-Karulis Bärbel , Naumann Michael , Olesen Jørgen E. , Savchuk Oleg , Schramm Andreas , Slomp Caroline P. , Sofiev Mikhail , Sobek Anna , Szymczycha Beata , Undeman Emma 
Published: March 2022

Abstract. Location, specific topography, and hydrographic setting together with climate change and strong anthropogenic pressure are the main factors shaping the biogeochemical functioning and thus also the ecological status of the Baltic Sea. The recent decades have brought significant changes in the Baltic Sea. First, the rising nutrient loads from land in the second half of the 20th century led to eutrophication and spreading of hypoxic and anoxic areas, for which permanent stratification of the water column and limited ventilation of deep-water layers made favourable conditions. Since the 1980s the nutrient loads to the Baltic Sea have been continuously decreasing. This, however, has so far not resulted in significant improvements in oxygen availability in the deep regions, which has revealed a slow response time of the system to the reduction of the land-derived nutrient loads. Responsible for that is the low burial efficiency of phosphorus at anoxic conditions and its remobilization from sediments when conditions change from oxic to anoxic. This results in a stoichiometric excess of phosphorus available for organic-matter production, which promotes the growth of N2-fixing cyanobacteria and in turn supports eutrophication. This assessment reviews the available and published knowledge on the
biogeochemical functioning of the Baltic Sea. In its content, the paper
covers the aspects related to changes in carbon, nitrogen, and phosphorus (C, N, and P) external loads, their transformations in the coastal zone, changes in organic-matter production (eutrophication) and remineralization (oxygen availability), and the role of sediments in burial and turnover of C, N, and P. In addition to that, this paper focuses also on changes in the marine CO2 system, the structure and functioning of the microbial community, and the role of contaminants for biogeochemical processes. This comprehensive assessment allowed also for identifying knowledge gaps and future research needs in the field of marine biogeochemistry in the Baltic Sea.
Environmental behaviors of (E) pyriminobac-methyl in agricultural soils
Authors: Zhou Wenwen , Jia Haoran , Liu Lang , Li Baotong , Li Yuqi , Gao Meizhu 
Published: March 2022

Abstract. E or pyriminobac-methyl (EPM), a pyrimidine benzoic acid esters herbicide, has a high potential as weedicide; nevertheless, its environmental behaviors are still not well understood. In this study, we systematically investigated, for the first time, the adsorption–desorption, degradation, and leaching behaviors of EPM in agricultural soils from five exemplar sites in China (Phaeozems – S1; Anthrosol – S2; Ferralsol – S3; Alisol – S4; Plinthosol – S5) through laboratory simulation experiments. Our results show that the EPM adsorption–desorption results were well fitted by the Freundlich model (R2>0.9999). In the analyzed soils, the Freundlich adsorption (i.e., Kf ads) and desorption (i.e., Kf des) coefficients of EPM varied between 0.85 and 32.22 mg1-1/n L1/n kg−1 and
0.78–5.02 mg1-1/n L1/n kg−1, respectively. The mobility of EPM in soils S1–S5 was categorized as immobile, slightly immobile, highly mobile, slightly mobile, and slightly mobile, respectively. Moreover, the degradation of EPM reflected first-order kinetics, where its half-life ranged between 37.46 and 66.00 d, depending on the environmental conditions, and abiotic degradation was predominant in the degradation of
this compound. Overall, the high leaching ability and desorption capacity of EPM were accompanied by a low adsorption capacity, and there were no significant relationships between pH and the leaching rate of EPM in the five types of soils. In contrast, the organic matter content, cation exchange capacity, and soil clay content were the main components responsible for the observed leaching rates. We found that EPM degrades easily, has a high adsorption affinity, and a low mobility in S1, which results in a low contamination risk for groundwater systems. On the contrary, this compound degrades slowly in S2, S3, S4, and S5, due to a low adsorption affinity and moderate mobility, which results in a high contamination risk for groundwater
systems. Therefore, our results may serve as a reference for evaluating the risks involved in the increasingly wide application of this compound.
Contribution of warm and moist atmospheric flow to a record minimum July sea ice extent of the Arctic in 2020
Authors: Liang Yu , Bi Haibo , Huang Haijun , Lei Ruibo , Liang Xi , Cheng Bin , Wang Yunhe 
Published: March 2022

Abstract. The satellite observations unveiled that the
July sea ice extent of the Arctic shrank to the lowest value, since
1979, in 2020 with a major ice retreat in the Eurasian shelf seas including Kara,
Laptev, and East Siberian seas. Based on the ERA-5 reanalysis products, we
explored the impacts of warm and moist air-mass transport on this extreme
event. The results revealed that anomalously high energy and moisture
converged into these regions in the spring months (April to June) of 2020,
leading to a burst of high moisture content and warming within the
atmospheric column. The convergence is accompanied by local enhanced
downward longwave surface radiation and turbulent fluxes, which is favorable
for initiating an early melt onset in the region with severe ice loss. Once
the melt begins, solar radiation plays a decisive role in leading to
further sea ice depletion due to ice–albedo positive feedback. The typical
trajectories of the synoptic cyclones that occurred on the Eurasian side in
spring 2020 agree well with the path of atmospheric flow. Assessments
suggest that variations in characteristics of the spring cyclones are
conducive to the severe melt of sea ice. We argue that large-scale
atmospheric circulation and synoptic cyclones acted in concert to trigger the
exceptional poleward transport of total energy and moisture from April to
June to cause this record minimum of sea ice extent in the following July.
Intervenciones comunitarias: Una forma de educación no formal
Authors: Abaunza Flores Julio Cesar , Castilla Karla Patricia 
Published: March 2022

Intervenciones comunitarias: Una forma de educación no formal. Proyecto Desarrollo socio-comunitario, mejora de la calidad de vida y prevención de riesgos sociales en los barrios más vulnerables de (Juigalpa Nicaragua). Intervención SocioComunitaria en Barrio 30 de mayo. IV Fase.
El Observatorio de la Calidad de Vida, inició en el año 2009, como una experiencia de cooperación internacional financiada por el Excelentísimo Ayuntamiento de dos Hermanas de Sevilla, España y por la Universidad Nacional Autónoma de Nicaragua, Managua; su propósito es promover la educación para la prevención de Enfermedades de Transmisión Sexual, VIH-SIDA, luchar contra las adicciones, promover hábitos de vida saludables e incentivar las medidas de seguridad laboral. Todo esto a través de charlas, seminarios, talleres y otras acciones concebidas para educar en estas temáticas.
La última edición de este proyecto se ejecutó en el Barrio 30 de mayo, Che Guevara y Pedro Joaquín Chamorro, entre otros y ha beneficiado a sectores específicos de la sociedad como niños y adolescentes en situación de riesgo en Juigalpa, Chontales, a través de acciones comunitarias en unión de diferentes actores sociales para contribuir al cumplimiento de los retos del milenio y la misión de la Universidad en sus políticas de extensión universitaria.
Los principales beneficiarios son: adolescentes, niños, jóvenes y ciudadanos de la población económicamente activa en estado vulnerable. Sus principales ejes de acción son: la formación de escuelas- talleres para mitigar los riesgos sociales de los niños, adolescentes y jóvenes, así como mejorar de las condiciones de salud de la población beneficiada e incidir en las prácticas de alimentación saludable por medio de huertos escolares y la mejora de la merienda escolar. Todo esto con un enfoque de educación no formal.
Echeveria (Crassulaceae): Potencial para la mejora genética como ornamental
Authors: Zúñiga Orozco Andrés , Carrodeguas González Ayerin 
Published: April 2022

El género Echeveria agrupa varias especies de plantas suculentas presentes en ambientes diversos, se encuentran en hábitats con suelos rocosos de poca profundidad, pendientes pronunciadas, cañones y rocas. Prácticamente todas las especies del género presentan interés económico, como plantas ornamentales, siendo comunes en colecciones de Crassulaceae. Los ejemplares que se encuentran en las colecciones son especies e híbridos del tipo interespecíficos e intergenéricos; sin embargo, aún se encuentran muchos sin identificar. Existen dificultades en la taxonomía del género por la falta de ejemplares en herbarios y por la ausencia de estudios moleculares, los cuales podrían brindar información valiosa tanto para la taxonomía como para estudios citogenéticos y otros de interés en el mejoramiento genético para su aprovechamiento comercial. En esta revisión hacemos una recopilación de información de lo que se conoce para el género en cuanto a cariotipado, diversidad genética, relaciones filogénicas y taxonomía, morfología floral, biología reproductiva, polinización, fitomejoramiento y aplicaciones biotecnológicas y moleculares; lo anterior enfocado en brindar perspectivas futuras para la mejora genética de Crassulaceae. En Echeveria sería de gran importancia la realización de estudios moleculares con el fin de ampliar la información actual sobre taxonomía del género y la aplicación de técnicas biotecnológicas que apoyen programas de mejora genética.