bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug-induced acute pancreatitis in a bodybuilder: a case report
Authors: Safizadeh Shabestari Seyed Ali , Ho Samuel B. , Chaudhary Priyadarshini , Nathwani Rahul A. 
Published: March 2022

AbstractBackgroundUnregulated use of a variety of drugs and supplements by bodybuilders and athletes is common and can lead to severe adverse complications. Only a small proportion of acute pancreatitis cases are drug induced, and case reports are essential for identifying potential drug-related risks for pancreatitis. Here we present the first case report published of acute pancreatitis linked to recreational use of anabolic–androgenic steroids, subcutaneous growth hormone, and clenbuterol in a previously healthy male after excluding all other causes of pancreatitis.Case presentationA 31-year-old Arab male bodybuilder presented with acute abdominal pain associated with nausea and sharp pain radiating to the back. The patient was not using tobacco or alcohol but was using multiple drugs related to bodybuilding, including anabolic–androgenic steroids, subcutaneous growth hormone, clenbuterol, and multiple vitamin supplements. Laboratory studies revealed a normal white blood cell count, elevated C-reactive protein, minimally elevated aspartate aminotransferase and total bilirubin with normal remaining liver tests, and elevated amylase and lipase. The patient had no hypertriglyceridemia or hypercalcemia, and had had no recent infections, abdominal procedures, trauma, or scorpion exposure. Imaging and laboratory investigations were negative for biliary disease and IgG4 disease. Abdominal computed tomography revealed hepatomegaly and diffuse thickening and edema of the body and tail of the pancreas with peripancreatic fat stranding. An abdominal ultrasound showed slight hepatomegaly with no evidence of cholelithiasis. Genetic testing for hereditary pancreatitis-related mutations was negative. A diagnosis of drug-induced acute pancreatitis was made, and he was treated with aggressive intravenous hydration and pain management. The patient has avoided further use of these drugs and supplements and had no further episodes of pancreatitis during 1 year of follow-up.ConclusionsThis case describes a patient with drug-induced acute pancreatitis after the intake of anabolic–androgenic steroids, subcutaneous growth hormone, and clenbuterol, where all other common causes of acute pancreatitis were excluded. Clinicians should be alert to the possibility of drug-induced acute pancreatitis occurring in bodybuilders and athletes using similar drug combinations.
Increased risk for thromboembolic events from combination of a gynecologic malignancy with severe acute respiratory syndrome coronavirus 2 infection: a case report
Authors: Stefan Alexandra , Petkovic Marija , König Alexander , Koch Julian , Hagemann Friederike , Wuerstlein Rachel , Harbeck Nadia , Mahner Sven , Kaltofen Till 
Published: March 2022

Abstract
Purpose
During the severe acute respiratory syndrome coronavirus 2 pandemic, several patient groups are at particular risk. Mortality is higher among cancer patients and may be increased further by thromboembolic events, which are more common in coronavirus 2019 patients according to recent publications. We discuss the association of gynecologic malignancies, Severe acute respiratory syndrome coronavirus 2, and thromboembolism by reporting a case study and summarizing available literature.

Case report
A 71-year-old Caucasian patient with ovarian cancer receiving first-line chemotherapy was diagnosed with deep vein thrombosis and pulmonary embolism. Routine screening revealed infection with severe acute respiratory syndrome coronavirus 2 in absence of specific symptoms. After uneventful recovery, oncologic treatment could be continued a few weeks later.

Methods
We performed a systematic review of the literature on PubMed following Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The search included articles ahead of print, published between 1 December 2019 and 1 June 2020. Cross-searches were conducted on all relevant articles.

Results
We identified five articles meeting the defined criteria, including two retrospective studies, a review, a position paper, as well as a letter to the editor.

Conclusion
Cancer patients infected with severe acute respiratory syndrome coronavirus 2 have a relatively poor outcome, which may partially be due to a higher rate of thromboembolic events. Thromboprophylaxis is recommended, and scoring systems are helpful in early detection. In cancer patients with severe acute respiratory syndrome coronavirus 2, individual risk for thromboembolic events should be taken into account when considering interruption versus continuation of antitumoral therapy. However, further data and studies are required.
SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1
Authors: Fung Sin-Yee , Siu Kam-Leung , Lin Huayue , Chan Ching-Ping , Yeung Man Lung , Jin Dong-Yan 
Published: March 2022

Abstract
Background
SARS-CoV-2 is the causative agent of COVID-19. Overproduction and release of proinflammatory cytokines are the underlying cause of severe COVID-19. Treatment of this condition with JAK inhibitors is a double-edged sword, which might result in the suppression of proinflammatory cytokine storm and the concurrent enhancement of viral infection, since JAK signaling is essential for host antiviral response. Improving the current JAK inhibitor therapy requires a detailed molecular analysis on how SARS-CoV-2 modulates interferon (IFN)-induced activation of JAK-STAT signaling.

Results
In this study, we focused on the molecular mechanism by which SARS-CoV-2 NSP13 helicase suppresses IFN signaling. Expression of SARS-CoV-2 NSP13 alleviated transcriptional activity driven by type I and type II IFN-responsive enhancer elements. It also prevented nuclear translocation of STAT1 and STAT2. The suppression of NSP13 on IFN signaling occurred at the step of STAT1 phosphorylation. Nucleic acid binding-defective mutant K345A K347A and NTPase-deficient mutant E375A of NSP13 were found to have largely lost the ability to suppress IFN-β-induced STAT1 phosphorylation and transcriptional activation, indicating the requirement of the helicase activity for NSP13-mediated inhibition of STAT1 phosphorylation. NSP13 did not interact with JAK1 nor prevent STAT1-JAK1 complex formation. Mechanistically, NSP13 interacted with STAT1 to prevent JAK1 kinase from phosphorylating STAT1.

Conclusion
SARS-CoV-2 NSP13 helicase broadly suppresses IFN signaling by targeting JAK1 phosphorylation of STAT1.
Understanding the phases of vaccine hesitancy during the COVID-19 pandemic
Authors: Kumar Dewesh , Mathur Mansi , Kumar Nitesh , Rana Rishabh Kumar , Tiwary Rahul Chandra , Raghav Pankaja Ravi , Kumar Amarendra , Kapoor Neelesh , Mathur Medha , Tanu Tanya , Sethia Soumitra , Lahariya Chandrakant 
Published: March 2022

AbstractVaccine hesitancy is an important feature of every vaccination and COVID-19 vaccination is not an exception. During the COVID-19 pandemic, vaccine hesitancy has exhibited different phases and has shown both temporal and spatial variation in these phases. This has likely arisen due to varied socio-behavioural characteristics of humans and their response towards COVID 19 pandemic and its vaccination strategies. This commentary highlights that there are multiple phases of vaccine hesitancy: Vaccine Eagerness, Vaccine Ignorance, Vaccine Resistance, Vaccine Confidence, Vaccine Complacency and Vaccine Apathy. Though the phases seem to be sequential, they may co-exist at the same time in different regions and at different times in the same region. This may be attributed to several factors influencing the phases of vaccine hesitancy. The complexities of the societal reactions need to be understood in full to be addressed better. There is a dire need of different strategies of communication to deal with the various nuances of all of the phases. To address of vaccine hesitancy, an understanding of the societal reactions leading to various phases of vaccine hesitancy is of utmost importance.
Long noncoding RNA Kcnq1ot1 prompts lipopolysaccharide-induced acute lung injury by microRNA-7a-5p/Rtn3 axis
Authors: Yang Shuo , Liu Fang , Wang Di 
Published: March 2022

Abstract
Background
Long noncoding RNA (lncRNA)-regulated mechanism in acute lung injury (ALI) has attracted special interests in study researches. We planned to disclose whether KCNQ1 overlapping transcript 1 (Kcnq1ot1) is involved in ALI and its mechanism.

Methods
The lipopolysaccharide (LPS)-induced ALI model was established in mice. Kcnq1ot1, microRNA (miR)-7a-5p and Reticulon 3 (Rtn3) levels were measured in lung tissues of mice. The vector that changed Kcnq1ot1, miR-7a-5p and Rtn3 expression was injected into LPS-treated mice, and pathological damage, fibrosis, apoptosis and inflammatory response were subsequently examined in lung tissues. The relation between Kcnq1ot1 and miR-7a-5p, and that between miR-7a-5p and Rtn3 were identified.

Results
Kcnq1ot1 and Rtn3 expression increased while miR-7a-5p expression decreased in LPS-treated mice. Reduced Kcnq1ot1 or elevated miR-7a-5p alleviated pathological damage, fibrosis, apoptosis and inflammatory response in ALI mice, while overexpressed Rtn3 worsened ALI in mice. Downregulation of Rtn3 reversed the exacerbation of miR-7a-5p downregulation in ALI mice. Kcnq1ot1 competitively bound to miR-7a-5p and miR-7a-5p negatively mediated Rtn3 expression.

Conclusion
Our experiments evidence that silencing Kcnq1ot1 upregulates miR-7a-5p to suppress Rtn3 expression, thereby diminishing LPS-induced ALI.
Estimation of above-ground biomass in tropical afro-montane forest using Sentinel-2 derived indices
Authors: Muhe Seid , Argaw Mekuria 
Published: March 2022

AbstractEmpirical analyses were common methods for forest biomass estimation. Lately, satellite images are popularly used to study different attributes of forest vegetation. Sentinel-2 image provides a significant improvement in spectral coverage, spatial resolution and temporal frequency in assessing forest biomass. This study examined the potential use of multispectral (MS) bands, vegetation indices and biophysical variables derived from Sentinel-2 images in modeling above-ground biomass (AGB) in tropical afro-montane forest of the Yayu biosphere reserve. A coupled method of remote sensing and statistics was applied to establish a biomass estimation model using spectral data generated from Sentinel-2 image and AGB data measured from the field. Multispectral bands, vegetation indices and biophysical variables were extracted from the Sentinel-2 image. Forest stand parameters such as DBH and tree height were measured from sampling plots to calculate AGB using allometric equations. The strength of correlation between the measured biomass and the MS bands, indices and biophysical variables were examined using Pearson’s product-moment correlation coefficients. A regression analysis was iteratively applied to identify the determinant variables for predicting AGB. The prediction results were validated based on the magnitude of coefficients of determination between the observed and the predicted values and the magnitude of the Root Mean Square Error (RMSE). A strong correlation (r ranging from 0.65 to 0.74) was observed between the biophysical variables from Sentinel-2 image and the measured AGB from the field. The MS Band 4 (red band), vegetation variables LAI, FCOVER and FAPAR, and band combination index IRECI yielded better results and are good predictor variables for forest AGB. The model goodness of fit between the observed and predicted AGB showed a coefficient of determination (r2) of 0.74 and RMSE of 0.16 ton C/pixel, which shows strong performance of the prediction model. Vegetation indices derived from Sentinel-2 imagery are good predictors of AGB in tropical afro-montane forests. Sentinel-2 image has improved the reliability of biomass estimation from remotely sensed data. Since field sampling plots were few in this study, the level of accuracy will likely improve with more number of field sample measurements.
Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling
Authors: Yang Yuan , Song Shuang , Nie Yuanyuan , Chen Rong , Chen Peng 
Published: March 2022

AbstractBackgroundArsenic, existing ubiquitously in soil, drinking water, or food, is well known to be an environmental pollutants concerned by European Food Safety Authority.Lentinan,a beta-1,6;1,3-glucan extracts fromLentinus edodes, which has the properties of antioxidant and immunomodulation, present study explored the pharmacological effects ofLentinanon arsenic induced hepatotoxicity in mice.MethodsMice experiments were performed by sodium arsenite (SA) treatment orLentinanintervention, then histopathology, ELISA, Flow Cytometry, or Western-Blotting were applied to evaluate hepatic injury, oxidative stress, CD4+type 17 helper T (Th17) cells, CD4+CD25+Foxp3+regulatory T cells (Tregs), T cells receptor OX40/CD134, IL-17A, NLRP3, Nrf2, and NQO1.ResultsSA treatment showed hepatic pathological injury and the elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) in serum, and induced the increases of malondialdehyde (MDA), Th17 cells, OX40 or IL-17A in liver tissues, which were consistently ameliorated byLentinanintervention. Further, immunoblotting experiments showed thatLentinanintervention downregulated the levels of OX40, IL-17A, and NLRP3 signals, while elevated the levels of anti-oxidative Nrf2, NQO1 signals compared to arsenic treatment group. For Tregs,Lentinanintervention showed no significant difference from SA treatment group.ConclusionLentinanantagonizes SA-induced hepatotoxicity in mice, may be involved in the downregulations of pro-inflammatory OX40 or IL-17A and the activation of anti-oxidative Nrf2, NQO1 signals.
The revised method for retrieving daytime distributions of atomic oxygen and odd-hydrogens in the mesopause region from satellite observations
Authors: Kulikov Mikhail Yu. , Belikovich Mikhail V. , Grygalashvyly Mykhaylo , Sonnemann Gerd R. , Feigin Alexander M. 
Published: March 2022

AbstractAtomic oxygen (O) and atomic hydrogen (H) in the mesopause region are critical species, governing chemistry, airglow, and energy budget. However, they cannot be directly measured by satellite remote sensing techniques and so inference techniques, by airglow observations, are used. In this work, we retrieved daytime O and H distributions at ~ 77 km–100 km from the data of observations by the SABER (Sounding of the Atmosphere using Broadband Emission Radiometry) instrument at the TIMED (Thermosphere Ionosphere Mesosphere Energetics and Dynamics) satellite in 2003–2015. The retrieval approach considered the reaction H + O3 → O2 + OH in the ozone balance equation. Moreover, we revised all quenching and spontaneous emission coefficients according to latest published data. We then calculated daytime distributions of OH and HO2 at these altitudes with the use of their conditions of photochemical equilibrium.
Graphical Abstract
Preoperative embolization strategy for the combined resection of replaced right hepatic artery in pancreaticoduodenectomy: a small case series
Authors: Takeuchi Shintaro , Ambo Yoshiyasu , Kodama Yoshihisa , Takada Minoru , Kato Kentaro , Nakamura Fumitaka , Hirano Satoshi 
Published: March 2022

Abstract
Background
Replaced right hepatic artery (rRHA) is a common vascular variation, and combined resection of this vessel is sometimes needed for the curative resection of pancreatic head malignancy. Safe surgical management has not been established, and there is a small number of reported cases. Here, we reported five cases, wherein preoperative embolization of rRHA was performed for combined resection.

Case presentation
All patients had pancreatic head malignancies that were in contact with rRHA. We performed a preoperative embolization of the rRHA before the scheduled pancreaticoduodenectomy for the combined resection. Arterial embolization was safely accomplished, and the communicating arcade from the left hepatic artery via the hilar plate was clearly revealed in all cases. Four patients underwent the operative procedure, except for one patient who had liver metastasis at laparotomy. No patient suffered from a severe abnormal liver function during the management; however, one patient had multiple liver infarctions during the postoperative course.

Conclusions
Preoperative embolization for the combined resection of rRHA in pancreaticoduodenectomy can be a management option for the precise evaluation of hemodynamics after sacrificing rRHA. In our cases, arterial flow to the right liver lobe was supplied by the left hepatic artery via the bypass route, including the communicating arcade of the hilar plate.
Influence of a novel suturing technique on periodontal health of mandibular second molar following impacted third molar surgery: a split-mouth randomized clinical trial
Authors: Esmaeelinejad Mohammad , Mansourian Mohammadhossein , Aghdashi Farzad 
Published: March 2022

Abstract
Background
Surgical extraction of the third molar is the most common surgical procedure in the oral surgery field and is associated with several complications. This study aimed to compare the effects of a newly presented suturing technique with the routine suture after surgical removal of the third molar on the postoperative complications.

Materials and methods
This randomized clinical trial was designed as a split-mouth double-blinded investigation. Twenty patients were involved in the current study. After the surgical removal of the third molar, the new suturing technique was used to close the wound on one side of the patient randomly (case side), and the other side was sutured by the routine simple interrupted stitches (control side). Pain, edema, trismus, pocket depth, and the attachment loss of the distal of the second molar were assessed following the surgery. The data were statistically analyzed and compared between the sides.

Results
Pain and edema following the surgery in the control side were significantly less than in the case side. The pocket depth and the gingival attachment loss of the distal aspect of the second molar in the case side were significantly less than in the control side. No case of dry socket was observed in the case side.

Conclusion
It seems that the newly presented suturing technique is able to keep the wound margins close to each other and may be helpful in reducing the periodontal complication of the second molar following the surgical removal of the impacted third molars.
Evaluation of peripheral neuropathy in lower limbs of patients with rheumatoid arthritis and its relation to fall risk
Authors: de Araújo Pereira Fabio , de Almeida Lourenço Mariana , de Assis Marcos Renato 
Published: March 2022

AbstractBackgroundRheumatoid Arthritis (RA) is a chronic disabling systemic disease characterized by joint inflammation, and extra-articular manifestations, including peripheral neuropathy, a condition that can be associated with changes in muscle strength, proprioception and postural balance contributing for the risk of falls. The objective of this study is to analyze the incidence of peripheral neuropathy in patients with RA and its association with the occurrence of falls.MethodsPatients were assessed by an electroneuromyography (ENMG) exam and by a questionnaire on accidental falls occurrence in the previous 12 months. They were also assessed on balance by the Short Physical Performance Battery (SPPB), functionality by the Health Assessment Questionnaire (HAQ), disease activity by the Disease Activity Score (DAS-28), neuropathic pain by the Questionnaire for the Diagnosis of Neuropathic Pain (DN4), and cutaneous sensitivity of the feet by the monofilament testing of Semmes–Weinstein. Monthly calls on falls were made in the subsequent six months. Data analysis was performed using the Shapiro–Wilk test for normality and Spearman, Chi-square, and T-student correlation tests, with a significant P level ≤ 0.05.ResultsA sample of 33 patients were evaluated. The incidence of peripheral neuropathy was 48.5%, of which 68.7% were axonal and 31.3% myelinic. The sensorimotor type was present in 64.7%, motor in 17.6%, and sensorial in 11.7% of the cases. Neuropathy was associated to balance (P = 0.026), neuropathic pain (P = 0.016), deep tendon reflexes absence (P = 0,049), altered skin sensitivity of the feet (P = 0.029) and fear of falling (P = 0.001). No association was found between peripheral neuropathy and age, gender, disease activity, or functionality. No significant association was found between peripheral neuropathy and occurrence of falls, in a 12-month retrospective and 6-month prospective evaluation.ConclusionPeripheral neuropathy has a high incidence in patients with RA, and is related to neuropathic pain, altered postural balance, but not to the occurrence of falls.
Non-adiabatic imprints on the low-energy structure in above-threshold ionization
Authors: Lin Z. Y. , Chen Y. , Li X. W. 
Published: March 2022

Abstract
We experimentally investigate the energy-resolved angular distributions (ADs) of low-energy photoelectrons from above-threshold ionization (ATI) of Xe in intense infrared laser fields. An unexpected wavelength dependence of ADs for the low-energy structure (LES), in striking contrast to the prediction of the Coulomb-corrected semiclassical model, has been found. By improving the semiclassical model with non-adiabatic corrections, the experimental features can be qualitatively reproduced, and we suggest the indispensable role of the non-adiabatic effect in producing the LES. Our finding provides new insights into the understanding of low-energy electron dynamics of atoms with intense laser fields.
Quantum oscillatory interaction between isovalent centers in semiconductors
Authors: Bao Kejie , Zhang Xiaodong , Chen Hang , Zhu Junyi 
Published: March 2022

Abstract
Interaction between isovalent centers is of great interest in device physics. We discovered a quantum oscillatory interaction based on the first principles calculations of two identical isovalent centers in C/Ge/Sn co-doped Si. The interaction is explained by Green's function's analysis and the linear combination of atomic orbitals (LCAO) method. One point defect interacts with another by a product between the defect potentials and the summation term that characterizes the metallization process of the host lattice. The trend of the oscillation is an intrinsic property of the host. The interaction mechanism is further verified by the calculations of the isovalent pairs with different elements. Our works shed light on the precise control of defects in semiconductors.