bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing and Implementing Predictive Models in a Learning Healthcare System: Traditional and Artificial Intelligence Approaches in the Veterans Health Administration
Authors: Atkins David , Makridis Christos A. , Alterovitz Gil , Ramoni Rachel , Clancy Carolyn 
Published: May 2022

Predicting clinical risk is an important part of healthcare and can inform decisions about treatments, preventive interventions, and provision of extra services. The field of predictive models has been revolutionized over the past two decades by electronic health record data; the ability to link such data with other demographic, socioeconomic, and geographic information; the availability of high-capacity computing; and new machine learning and artificial intelligence methods for extracting insights from complex datasets. These advances have produced a new generation of computerized predictive models, but debate continues about their development, reporting, validation, evaluation, and implementation. In this review we reflect on more than 10 years of experience at the Veterans Health Administration, the largest integrated healthcare system in the United States, in developing, testing, and implementing such models at scale. We report lessons from the implementation of national risk prediction models and suggest an agenda for research.
Hematopoietic Prostaglandin D2 Synthase Controls Tfh/Th2 Communication and Limits Tfh Antitumor Effects
Authors: Mary Romain , Chalmin Fanny , Accogli Théo , Bruchard Mélanie , Hibos Christophe , Melin Joséphine , Truntzer Caroline , Limagne Emeric , Derangère Valentin , Thibaudin Marion , Humblin Etienne , Boidot Romain , Chevrier Sandy , Arnould Laurent , Richard Corentin , Klopfenstein Quentin , Bernard Antoine , Urade Yoshihiro , Harker James A. , Apetoh Lionel , Ghiringhelli François , Végran Frédérique 
Published: May 2022

AbstractT follicular helper (Tfh) cells are a subset of CD4+ T cells essential in immunity and have a role in helping B cells produce antibodies against pathogens. However, their role during cancer progression remains unknown. The mechanism of action of Tfh cells remains elusive because contradictory data have been reported on their protumor or antitumor responses in human and murine tumors. Like Tfh cells, Th2 cells are also involved in humoral immunity and are regularly associated with tumor progression and poor prognosis, mainly through their secretion of IL4. Here, we showed that Tfh cells expressed hematopoietic prostaglandin D2 (PGD2) synthase in a pSTAT1/pSTAT3-dependent manner. Tfh cells produced PGD2, which led to recruitment of Th2 cells via the PGD2 receptor chemoattractant receptor homologous molecule expressed on Th type 2 cells (CRTH2) and increased their effector functions. This cross-talk between Tfh and Th2 cells promoted IL4-dependent tumor growth. Correlation between Th2 cells, Tfh cells, and hematopoietic PGD2 synthase was observed in different human cancers and associated with outcome. This study provides evidence that Tfh/Th2 cross-talk through PGD2 limits the antitumor effects of Tfh cells and, therefore, could serve as a therapeutic target.
Respective and Combined Impacts of North Indian Ocean and Tropical North Atlantic SST Anomalies on the Subseasonal Evolution of Anomalous Western North Pacific Anticyclones
Authors: Feng Juan , Chen Wen 
Published: May 2022

Abstract
The subseasonal variation of the anomalous western North Pacific anticyclone (WNPAC) has important implications for East Asian summer monsoon variability. How the WNPAC evolves on the subseasonal time scale under the different configurations of tropical North Atlantic (TNA) Ocean and north Indian Ocean (NIO) SST warming is elucidated in this study. The WNPAC forced by individual TNA SST warming shows an obvious subseasonal variation with a stepwise northward movement. In contrast, the WNPAC forced by individual NIO SST warming shows a weak subseasonal variation, being nearly stabilized at around 20°N from June to August and thereby causing long-lasting and intense positive mei-yu–baiu–changma rainfall anomalies. The physical mechanism for the different subseasonal variation of WNPAC is further investigated. The TNA SST warming generates a WNPAC via a Rossby wave–induced divergence/convergence chain response. In this process, the TNA SST warming-induced suppressed convection over the western Pacific moves northward with the northward movement of climatological intertropical convergence zone and summer monsoon region, which generates a northward shift of the WNPAC. However, the NIO SST warming produces a WNPAC via a Kelvin wave–induced suppressed convection over the western Pacific Ocean. This suppressed convection is stabilized at around 20°N because of the Kelvin wave activity scope being limited within 20°N, which finally produces a nearly stationary WNPAC from June to August. In addition, under the simultaneous occurrence of the TNA and NIO SST warming, the subseasonal variation of WNPAC bears a resemblance to that for the individual NIO SST warming condition, where the TNA SST warming fails to exert its impact.
The Impact of Southern Ocean Topographic Barriers on the Ocean Circulation and the Overlying Atmosphere
Authors: de Boer Agatha M. , Hutchinson David K. , Roquet Fabien , Sime Louise C. , Burls Natalie J. , Heuzé Céline 
Published: May 2022

Abstract
Southern Ocean bathymetry constrains the path of the Antarctic Circumpolar Current (ACC), but the bathymetric influence on the coupled ocean–atmosphere system is poorly understood. Here, we investigate this impact by respectively flattening large topographic barriers around the Kerguelen Plateau, Campbell Plateau, Mid-Atlantic Ridge, and Drake Passage in four simulations in a coupled climate model. The barriers impact both the wind and buoyancy forcing of the ACC transport, which increases by between 4% and 14% when barriers are removed individually and by 56% when all barriers are removed simultaneously. The removal of Kerguelen Plateau bathymetry increases convection south of the plateau and the removal of Drake Passage bathymetry reduces convection upstream in the Ross Sea. When the barriers are removed, zonal flattening of the currents leads to sea surface temperature (SST) anomalies that strongly correlate to precipitation anomalies, with correlation coefficients ranging between r = 0.92 and r = 0.97 in the four experiments. The SST anomalies correlate to the surface winds too in some locations. However, they also generate circumpolar waves of sea level pressure (SLP) anomalies, which induce remote wind speed changes that are unconnected to the underlying SST field. The meridional variability in the wind stress curl contours over the Mid-Atlantic Ridge, the Kerguelen Plateau, and the Campbell Plateau disappears when these barriers are removed, confirming the impact of bathymetry on surface winds. However, bathymetry-induced wind changes are too small to affect the overall wave-3 asymmetry in the Southern Hemisphere westerlies. Removal of Southern Hemisphere orography is also inconsequential to the wave-3 pattern.

Significance Statement
Several studies in the past have pointed to the controlling effect of bathymetry on currents in the Southern Ocean circulation, but a clear idea of the importance of the major topographic barriers in the Southern Ocean is lacking. By removing these barriers systematically in a coupled climate model, we can evaluate their impact on several important components of the climate system, such as the Antarctic Circumpolar Current (ACC) pathways and strength, Antarctic Bottom Water formation, sea surface temperature, overlying winds, air–sea fluxes, and even precipitation. This helps in our understanding of what controls the pathways of the ACC and how much it matters for climate.
The High-Resolution Rapid Refresh (HRRR): An Hourly Updating Convection-Allowing Forecast Model. Part II: Forecast Performance
Authors: James Eric P. , Alexander Curtis R. , Dowell David C. , Weygandt Stephen S. , Benjamin Stanley G. , Manikin Geoffrey S. , Brown John M. , Olson Joseph B. , Hu Ming , Smirnova Tatiana G. , Ladwig Terra , Kenyon Jaymes S. , Turner David D. 
Published: May 2022

Abstract
The High-Resolution Rapid Refresh (HRRR) is a convection-allowing implementation of the Advanced Research version of the Weather Research and Forecast (WRF-ARW) Model that covers the conterminous United States and Alaska and runs hourly (for CONUS; every 3 h for Alaska) in real time at the National Centers for Environmental Prediction. The high-resolution forecasts support a variety of user applications including aviation, renewable energy, and prediction of many forms of severe weather. In this second of two articles, forecast performance is documented for a wide variety of forecast variables and across HRRR versions. HRRR performance varies across geographical domain, season, and time of day depending on both prevalence of particular meteorological phenomena and the availability of both conventional and nonconventional observations. Station-based verification of surface weather forecasts (2-m temperature and dewpoint temperature, 10-m winds, visibility, and cloud ceiling) highlights the ability of the HRRR to represent daily planetary boundary layer evolution and the development of convective and stratiform cloud systems, while gridded verification of simulated composite radar reflectivity and quantitative precipitation forecasts reveals HRRR predictive skill for summer and winter precipitation systems. Significant improvements in performance for specific forecast problems are documented for the upgrade versions of the HRRR (HRRRv2, v3, and v4) implemented in 2016, 2018, and 2020, respectively. Development of the HRRR model data assimilation and physics paves the way for future progress with operational convective-scale modeling.

Significance Statement
NOAA’s operational hourly updating convection-allowing model, the High-Resolution Rapid Refresh (HRRR), is a key tool for short-range weather forecasting and situational awareness. Improvements in assimilation of weather observations, as well as in physics parameterizations, has led to improvements in simulated radar reflectivity and quantitative precipitation forecasts since the initial implementation of HRRR in September 2014. Other targeted development has focused on improved representation of the diurnal cycle of the planetary boundary layer, resulting in improved near-surface temperature and humidity forecasts. Additional physics and data assimilation changes have led to improved treatment of the development and erosion of low-level clouds, including subgrid-scale clouds. The final version of HRRR features storm-scale ensemble data assimilation and explicit prediction of wildfire smoke plumes.
Applicant Perspectives of Virtual General Surgery Residency Interviews
Authors: Finney Nicole , Stopenski Stephen , Smith Brian R. 
Published: May 2022

Background The coronavirus 2019 (COVID-19) pandemic prompted drastic changes to residency recruitment. The majority of general surgery residency interviews for the 2020-2021 interview cycle were restructured into a virtual format. The goal of this study is to evaluate general surgery residency applicants’ perception of virtual interviews. Methods A secure, anonymous, web-based survey was developed, tested, and distributed via email to all candidates who applied to the University of California Irvine general surgery residency program for Match 2021. Results 1239 general surgery applicants were invited after Match Day 2021 to take the survey, and 167 (13.5%) completed the survey and were included in the final analysis. Applicants received and accepted a median of 10 (Interquartile range [IQR], 5-18) and 9 (IQR, 5-15) interviews. Using a Likert scale, candidates revealed they were most satisfied with introduction and program overview (72.5%) and interactions with faculty (70.6%). Applicants were dissatisfied with pre-interview socials (66.9%) and hospital tours (66.2%). When evaluating programs, they had the most difficulty discerning program culture and resident autonomy. Most applicants (54%) were satisfied with the virtual format and 52% believed that virtual format should continue. Discussion The majority of applicants were satisfied with virtual interviews and could foresee the format continuing in the future.
Establishment of a novel ELISA system for measuring periostin independently of formation of the IgA complex
Authors: Takai Masayuki , Ono Junya , Okamoto Masaki , Fujimoto Kiminori , Kamei Ayami , Nunomura Satoshi , Nanri Yasuhiro , Ohta Shoichiro , Hoshino Tomoaki , Azuma Arata , Izuhara Kenji 
Published: May 2022

Background Periostin, a matricellular protein that modulates cell functions having various pathophysiological roles, has the potential to be a useful biomarker for various diseases. We recently found that periostin forms a complex with IgA in human serum, which may affect the periostin measurement. Methods We investigated (1) whether the formation of the periostin-IgA complex affects the original periostin ELISA system, decreasing the values of serum periostin? (2) bow each domain of periostin affects periostin measurement by the original periostin ELISA system? (3) whether we can establish a novel ELISA system that is not affected by formation of the IgA complex? Results The periostin value at the reducing condition was significantly higher than that of the non-reducing condition, demonstrating that formation of the IgA complex affects periostin measurement. The monoclonal antibodies (mAbs) for periostin recognizing the EMI and R1 domains immunoprecipitated serum periostin in the reducing condition more than in the non-reducing condition, whereas the mAbs recognizing the R2 or R3 domain immunoprecipitated comparable amounts of serum periostin in the reducing and non-reducing conditions, suggesting the EMI and R1 domains contribute to formation of the complex with IgA. Using SS16A recognizing the R3 domain combined with SS17B recognizing the R4 domain, we established an ELISA system that was able to measure periostin independently of the IgA complex. Conclusions We have established a novel ELISA system that measures periostin independently of the IgA complex. This system is promising in identifying periostin as a biomarker for various diseases.
Cystic Neuronal Necrosis of Posterior Thalami in Neonatal Hypoxic Ischemic Encephalopathy: A Case Report of an Unusual Radiological Finding
Authors: A. Ebinesh , Manchanda Alpana , Saraswat Prerana , Futela Dheeman , Kumar Ajay 
Published: May 2022

Background: Neonatal hypoxic ischemic encephalopathy (HIE) occurs as a result of any event that causes hypoxia and hypoperfusion to the developing neonatal brain. In addition to being a major cause of neonatal mortality, it is also associated with significant long-term neurological deficits. Multicystic encephalomalacia is a sequelae to global hypoxic ischemic injury which is characterized by cortical atrophy, basal ganglia/thalamic atrophy, and cystic necrosis of cerebral white matter. In this report, we present an unusual finding of cystic necrosis of thalami in HIE. Case Presentation: We present the case of a term neonate with a history of prolonged labor and meconium aspiration who developed HIE stage III. The neonate initially required ventilator support and was gradually weaned off but was reintubated in view of neonatal sepsis. Magnetic resonance imaging done on day 23 revealed diffuse cortical and white matter atrophy, signal intensity alteration in basal ganglia and thalami, and multiple well-defined areas of cerebrospinal fluid signal intensity in the white matter, consistent with multicystic encephalomalacia. An additional unusual finding was cystic necrosis, symmetrically involving bilateral posterior thalami. Conclusion: According to our observation, severe prolonged hypoxic ischemic insult does not only result in central gray matter atrophy but can also cause cystic neuronal necrosis of the same.
Telephone calls and glycemic control in type 2 diabetes: A PRISMA-compliant systematic review and meta-analysis of randomized clinical trials
Authors: Moreira Ana Marina , Marobin Roberta , Escott Gustavo Monteiro , Rados Dimitris Varvaki , Silveiro Sandra Pinho 
Published: May 2022

Aims In-depth and updated systematic reviews evaluating telephone calls in type 2 diabetes (T2DM) management are missing. This study aimed to assess the effect of this intervention on glycemic control in T2DM patients when compared with usual care. Methods We systematically searched for randomized controlled trials (RCT) on T2DM using Medline, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and LILACS, up to March 2021. The Risk of Bias 2.0 (Rob 2.0) tool and GRADE were used for the quality evaluation. The intervention effect was estimated by the change in glycated hemoglobin (HbA1c). PROSPERO registry CRD42020204519. Results 3545 references were reviewed and 32 were included (8598 patients). Telephone calls, all approaching education, improved HbA1c by 0.33% [95% CI, −0.48% to −0.18%; I2 = 78%; p < 0.0001] compared to usual care. A greater improvement was found when the intervention included pharmacologic modification (−0.82%, 95% CI, −1.42% to −0.22%; I2 = 92%) and when it was applied by nurses (−0.53%, 95% CI, −0.86% to −0.2%; I2 = 87%). Meta-regression showed no relationship between DM duration and HbA1c changes. Conclusion The telephone call intervention provided a benefit regarding T2DM glycemic control, especially if provided by nurses, or if associated with patient education and pharmacological treatment modification.
Comparative cost analysis of liquid embolization systems for brain arteriovenous malformation using a real-world US hospital database: TRUFILL® versus OnyxTM
Authors: Satti Sudhakar R , Fan Xiaozhou , Kottenmeier Emilie , Khanna Rahul , Rai Ansaar T 
Published: May 2022

Background Liquid embolic systems (LES) such as n-butyl cyanoacrylate-based TRUFILL® and ethylene vinyl-alcohol copolymer-based OnyxTM are widely used for the embolization of brain arteriovenous malformations (bAVMs). The purpose of this study was to compare hospital cost and length of stay (LOS) among unruptured bAVM patients undergoing embolization procedures with TRUFILL versus Onyx LES. Methods Adult patients with unruptured bAVMs undergoing endovascular embolization with TRUFILL or Onyx LES between January 1, 2010 and June 30, 2020 were identified from the Premier Healthcare Database. Baseline covariates among the two groups were balanced using propensity score matching. Outcomes including total procedure cost, supply cost, and LOS were examined. A Generalized Estimating Equation model was used to assess outcomes in the matched cohorts. Results A total of 1072 patients were included in the study; 140 embolized with TRUFILL (mean age 47.06 [15.72] years, 45.70% male) and 932 embolized with Onyx (mean age 46.80 [16.65] years, 52.30% male). In the post-match cohort, the total procedure costs were lower for the TRUFILL (n = 130) versus Onyx (n = 333) group, though not significantly ($36,798 vs. $40,988; odds ratio [OR] = 0.90, 95% confidence interval [CI]: 0.73–1.10; p = 0.30). However, supply cost was significantly lower for hospitalizations with TRUFILL compared to Onyx use ($13,281 vs. $16,371, OR = 0.81, 95% CI: 0.68, 0.98; p = 0.026). Hospital LOS was similar in these two groups (TRUFILL: 4.05 vs. Onyx: 4.06 days; OR = 1.00, 95% CI: 0.70, 1.42; p = 0.99). Conclusions In a large, multi-center, real-world sample of patients undergoing bAVM embolization, TRUFILL use was associated with significantly lower supply cost compared to Onyx use.
Efficacy of oleandrin and PBI-05204 against bovine viruses of importance to commercial cattle health
Authors: Newman Robert A. , Chase Christopher C.L. , Matos Jose R. , Abdelsalam Karim , Buterbaugh Robin , Van Holland Sonja , Abdelaal Hadia , Woolum Amelia , Jagannadha Sastry K 
Published: May 2022

Background Bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV). and bovine coronavirus (BCV) threaten the productivity of cattle worldwide. Development of therapeutics that can control the spread of these viruses is an unmet need. The present research was designed to explore the in vitro antiviral activity of the Nerium oleander derived cardiac glycoside oleandrin and a defined N. oleander plant extract (PBI-05204) containing oleandrin. Methods Madin Darby Bovine Kidney (MDBK) cells, Bovine Turbinate (BT) cells, and Human Rectal Tumor-18 (HRT-18) cells were used as in vitro culture systems for BVDV, BRSV and BCV, respectively. Cytotoxicity was established using serial dilutions of oleandrin or PBI-05204. Noncytotoxic concentrations of each drug were used either prior to or at 12 h and 24 h following virus exposure to corresponding viruses. Infectious virus titers were determined following each treatment. Results Both oleandrin as well as PBI-05204 demonstrated strong antiviral activity against BVDV, BRSV, and BCV, in a dose-dependent manner, when added prior to or following infection of host cells. Determination of viral loads by PCR demonstrated a concentration dependent decline in virus replication. Importantly, the relative ability of virus produced from treated cultures to infect new host cells was reduced by as much as 10,000-fold at noncytotoxic concentrations of oleandrin or PBI-05204. Conclusions The research demonstrates the potency of oleandrin and PBI-05204 to inhibit infectivity of three important enveloped bovine viruses in vitro. These data showing non-toxic concentrations of oleandrin inhibiting infectivity of three bovine viruses support further investigation of in vivo antiviral efficacy.
Identifying factors associated with neonatal resuscitation skills among nurses and midwives in Tanzania, sub-Saharan Africa
Authors: Mbinda Mathias Anthony , Moshi Fabiola Vincent 
Published: May 2022

Objective: The objective of this study was to identify factors associated with nurses’ and midwives’ skills in performing neonatal resuscitation. Method: Health facility-based analytical cross-sectional study design was employed from January 2021 to April 2021 among 340 nurses and midwives selected by multistage random sampling technique. An observation checklist was used to collect data. Data were coded and entered into SPSS version 20 for analysis. Bivariate and multivariate logistic regression was used to assess factors associated with nurse/midwives’ skills in neonatal resuscitation. Results: Among 340 nurses and midwives, 141 (41%) had adequate skills in neonatal resuscitation. After adjusting for confounders, factors associated with adequate skills were; age of the midwives (20–34 (adjusted odds ratio = 0.082, p < 0.008) and 35–49 (adjusted odds ratio = 0.087, p < 0.010)); work experience (worked 4–6 (adjusted odds ratio = 2.905, p < 0.003) and > 10 years and above (adjusted odds ratio = 12.825, p < 0.000)); district hospitals (adjusted odds ratio = 1.544, p = 0.032); distance from place of residence (6–10 km (adjusted odds ratio = 0.090, p < 0.001) and > 16 km (adjusted odds ratio = 0.049, p < 0.001)); number of midwives per shift, ⩾ 4 (adjusted odds ratio = 2.396, p = 0.012) and number of deliveries per day (6–10 (adjusted odds ratio = 1.385, p < 0.031), 11–20 (adjusted odds ratio = 2.693, p < 0.016) and > 20 delivery per day (adjusted odds ratio = 6.007, p < 0.001). Conclusion: Less than half of the observed nurses and midwives had adequate skills in neonatal resuscitation. Nurses and midwives who were younger, less experienced (<4 years of work experience), and work in small, lower volume settings with fewer colleagues and limited births (dispensaries, fewer than four nurses and midwives per shift, less than six deliveries per day) were less likely to have adequate skills in neonatal resuscitation. Knowledge gained from this study may provide future research related to a cost-effective strategy to empower nurses and midwives in neonatal resuscitation.