bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Metaphysics of gender is (Relatively) substantial
Authors: Richardson Kevin 
Published: August 2022

AbstractAccording to Sider, a question is metaphysically substantive just in case it has a single most natural answer. Recently, Barnes and Mikkola have argued that, given this notion of substantivity, many of the central questions in the metaphysics of gender are nonsubstantive. Specifically, it is plausible that gender pluralism—the view that there are multiple, equally natural gender kinds—is true, but this view seems incompatible with the substantivity of gender. The goal of this paper is to argue that the notion of substantivity can be understood in a way that accommodates gender pluralism. First, I claim that gender terms (at least as used in the ontology room) are referentially indeterminate, where referential indeterminacy holds in virtue of the way the world is. Second, I propose a degree‐theoretic (or scalar) account of metaphysical substantivity; genders are substantial to the degree that they are determinate. I conclude that gender is relatively, although not absolutely, substantial.
Quantification of rosmarinic acid from different plant species of lower Himalayan region and expression analysis of underlying L‐Phenylalanine pathway
Authors: Mughees Muhammad , Farooq Muhammad Asad , Haq Ihsan Ul , Zeb Iftikhar , Ali Muhammad , Hussain Zahoor , Shahzadi Irum , Shah Mohammad Maroof 
Published: August 2022

AbstractThis study adopts a very effective high‐performance liquid chromatography (HPLC) technique for the quantitative determination of rosmarinic acid (RA) and PCR‐based amplification of biosynthetic key regulators in Isodon rugosus, Daphne mucronata, and Viburnum grandiflorum from the lower Himalayan regions. Rosmarinic acid is engaged in a variety of biological processes and has significant industrial significance. In this study, it was identified from crude methanolic extract using thin‐layer chromatography with a standard, and its content was quantified using HPLC without interrupting spikes using a mixture of methanol and deionized water containing acetonitrile (70:30 v/v) and acetic acid (0.1% v/v) at UV 310 nm absorption. We used RT‐PCR to identify cDNAs encoding PAL, C4H, and RAS, and Image J's semi‐quantitative analysis to quantify the expression levels of genes involved in RA production from chosen plant material. The highest levels of PAL, C4H, and RAS were detected, by band intensity, in the leaves and flowers of I. rugosus, which also exhibited a substantial quantity of RA. However, in V. grandiflorum and D. mucronata the transcript of the given genes was low. The concentration of RA ranged from 187.7 to 21.2 mg g−1 for I. rugosus, 17.42 to 5.42 mg g−1 for V. grandiflorum, and 15.19 mg g−1 for D. mucronata. This study demonstrated that the method for quantifying RA from a crude methanolic extract was effective, indicating that I. rugosus might be used as an indigenous alternative source of RA.
Regulating ethics in financial services: Engaging industry to achieve regulatory objectives
Authors: McGrath Joe , Walker Ciaran 
Published: August 2022

AbstractThis article addresses the issue of renewing a sense of vocation in finance. Drawing on experiences in the UK, Australia, and Ireland, three common law jurisdictions at various phases of developing “an ethical esprit de corps” to professionalize the banking industry, it argues that adopting some aspects of a profession, a “trajectory towards professionalization” of the banking industry, could serve, at least to some extent, to improve the industry‐wide norms that influence firms' cultures and individual behaviors. It contends that professionalization could help to develop bankers with a professional, pro‐social identity, in which there is a recognition of broader obligations to society, that exists independently of the profit‐driven nature of banking and the hierarchy of their own firms. This analysis is informed by an integration of regulatory theory, which casts doubt on the utility of sanctions except as a last resort, behavioral science, which offers insights into how ethics and culture, not just law and markets, can constrain irresponsible behavior in the financial services sector, and criminological theory, which emphasizes that particular types of controls, including individual attachments to groups, build “stakes in conformity” which encourage law abiding and responsible behaviors.
The association of soluble Klotho levels with anemia and hemoglobin variability in hemodialysis patients
Authors: Topal Mustafa , Guney Ibrahim 
Published: August 2022

AbstractIntroductionThe anti‐aging protein Klotho levels are decreased, and Klotho deficiency is associated with cardiovascular diseases in patients with chronic kidney disease. There are recent studies about the relation between soluble Klotho levels and anemia. We aimed to investigate the correlation of anemia and hemoglobin variability with soluble Klotho levels in hemodialysis patients.MethodsNinety‐one hemodialysis patients were included in this study. The mean hemoglobin value, hemoglobin variability, and coefficient of variation of hemoglobin for each patient were calculated. According to mean hemoglobin levels, two groups were defined as under 11 and ≥11 g/dl. Soluble Klotho levels of each patient were studied.ResultsMean hemoglobin levels, hemoglobin variability, and coefficient of variation of hemoglobin were not significantly correlated with soluble Klotho levels. According to mean hemoglobin levels under 11 and ≥ 11 g/dl, there was no statistically significant correlation between anemia and soluble Klotho levels.ConclusionSoluble Klotho levels were not associated with anemia and hemoglobin variability in hemodialysis patients. Further studies are needed to reveal the complicated relation between anemia and soluble Klotho levels.
Polynesianising and regenerating urban spaces: An analysis of the artworks and interventions of the Centre des Métiers d'Art de Polynésie française and of its artists
Authors: Castro‐Koshy Estelle , Devatine Tokainiua 
Published: August 2022

AbstractThis article studies the relationships that the Centre des Métiers d’Art de la Polynésie française (CMA—Centre for Arts and Crafts of French Polynesia), five contemporary artists connected to it, and their artworks, have with the city of Pape'ete and its urban environment. The first part analyses the teaching philosophy of the CMA and foregrounds its role as a tool of social mobility for its students and in reinforcing positive representations of Indigenous Polynesians and heritage. The second part examines how the initiatives led by the CMA in Pape'ete are invitations to a shift in mindset. The third part explores how the artists express and reflect on their sense of belonging and highlights how their relationship with urban areas is enriched by their life experiences and their family roots in broader territories.
KOOS-Child exhibits inadequate structural validity in a cohort of paediatric patients with ACL deficiency
Authors: Hansen Christian Fugl , Østergaard Madsen Maria , Warming Susan , Rathcke Martin Wyman , Krogsgaard Michael , Christensen Karl Bang 
Published: August 2022

ObjectivesKnee injury and Osteoarthritis Outcome Score (KOOS)-Child is a modification of the adult KOOS aiming to evaluate knee injury, including ACL deficiency. However, the measurement properties of KOOS-Child have not been assessed in a cohort of children with ACL deficiency. We aimed to study the structure of KOOS-Child using modern test theory models (Rasch analysis and confirmatory factor analysis (CFA)).MethodsData were collected prospectively in a cohort of children with ACL deficiency at three time points: before-and-after ACL surgery, and at 1-year follow-up. For each subscale, structural validity through the fit of a CFA model was evaluated for 153 respondents. Modification indices were examined to find the model of best fit, confirmed using Rasch analysis. Responsiveness was reported for each subscale. Reliability was calculated for each item. Floor and ceiling effects, and Person-item distribution were reported.ResultsAll subscales showed inadequate fit to a unidimensional CFA model. Rasch analysis confirmed these results. Adjusting the subscales improved model fit, although this was still quite poor, except for the quality of life subscale. With one exception, all items demonstrated ceiling effects. Person-item distribution confirmed this. Due to lack of fit, reliability was not reported. All subscales were able to detect change from baseline to 1-year follow-up.ConclusionsKOOS-Child exhibits inadequate measurement properties in its current form for children with ACL deficiency. Suggestions to make the subscales fit the models better and improve accuracy of KOOS-Child are presented. However, the large ceiling effects observed may reduce sensitivity and induce type 2 errors.
Perinatal excellence to reduce injury in preterm birth (PERIPrem) through quality improvement
Authors: Glover Williams Alessandra , Tuvey Sam , McBain Hayley , Menzies Noshin , Hedge Sally , Bates Sarah , Luyt Karen 
Published: August 2022

Perinatal Excellence to Reduce Injury in Premature Birth (PERIPrem) is an 11-element perinatal care bundle designed to improve outcomes for preterm babies, in line with the National Health Service (NHS) Long Term plan. Designed in collaboration with 12 NHS Trusts (secondary care hospitals), South West and West of England Academic Health Science Networks, South West Neonatal Operational Delivery Network, parent partners and clinical experts, implementation was via bespoke quality improvement (QI) methodology. Before project initiation, there was regional variation in uptake of elements, evidenced by baseline audit. Optimisation of the preterm infant is complex; eligibility for treatments is dependent on gestation and local policies. Preterm infants experience variability in care dependent on the place of birth, and there remains an implementation gap for several effective, evidence-based treatments.The PERIPrem ambition is to reduce severe brain injury and death caused by prematurity by at least 50% through the delivery of a perinatal care bundle. The PERIPrem approach resulted in improved element implementation by 26% (from 3% to 29%) between 2019 and 2021, with dyads significantly more likely to receive the full bundle in 2021 compared with 2019 (probability=0.96 (95% CI 0.87 to 0.99), p<0.001). When examining the impact on psychological safety and team-working of PERIPrem, linear mixed models indicated an improvement in team function (p=0.021), situation monitoring (p=0.029) and communication within teams (p=0.002). Central to success was the development of a committed multiorganisational collaborative that continues to drive perinatal improvement using a common language and streamlining processes. In addition to saving the lives of the most vulnerable babies, PERIPrem aims to improve the chances of disability-free lives and is successfully nurturing high-functioning perinatal teams with enhanced QI skills.
miR-196b–TLR7/8 Signaling Axis Regulates Innate Immune Signaling and Myeloid Maturation in DNMT3A-Mutant AML
Authors: Gamlen Holly A. , Romer-Seibert Jennifer S. , Lawler Michael E. , Versace Amanda M. , Goetz Melanie L. , Feng Yang , Guryanova Olga A. , Palmisiano Neil , Meyer Sara E. 
Published: August 2022

Abstract

Purpose:
DNMT3A mutations confer a poor prognosis in acute myeloid leukemia (AML), but the molecular mechanisms downstream of DNMT3A mutations in disease pathogenesis are not completely understood, limiting targeted therapeutic options. The role of miRNA in DNMT3A-mutant AML pathogenesis is understudied.

Experimental Design:
DNA methylation and miRNA expression was evaluated in human AML patient samples and in Dnmt3a/Flt3-mutant AML mice. The treatment efficacy and molecular mechanisms of TLR7/8-directed therapies on DNMT3A-mutant AML were evaluated in vitro on human AML patient samples and in Dnmt3a/Flt3-mutant AML mice.

Results:
miR-196b is hypomethylated and overexpressed in DNMT3A-mutant AML and is associated with poor patient outcome. miR-196b overexpression in DNMT3A-mutant AML is important to maintain an immature state and leukemic cell survival through repression of TLR signaling. The TLR7/8 agonist resiquimod induces dendritic cell–like differentiation with costimulatory molecule expression in DNMT3A-mutant AML cells and provides a survival benefit to Dnmt3a/Flt3-mutant AML mice. The small molecule bryostatin-1 augments resiquimod-mediated AML growth inhibition and differentiation.

Conclusions:
DNMT3A loss-of-function mutations cause miRNA locus-specific hypomethylation and overexpression important for mutant DNMT3A–mediated pathogenesis and clinical outcomes. Specifically, the overexpression of miR-196b in DNMT3A-mutant AML creates a novel therapeutic vulnerability by controlling sensitivity to TLR7/8-directed therapies.
An Informatics Bridge to Improve the Design and Efficiency of Phase I Clinical Trials for Anticancer Drug Combinations
Authors: Wang Lei , Wei Lai , Zhang Shijun , Cheng Lijun , Shendre Aditi , Carson Williams , Chen James L. , Owen Dwight , Gregory Megan , Li Lang 
Published: August 2022

In this study, we summarized critical databases of drug combination toxicity and pharmacokinetics. We further conducted a feasibility and utility study that demonstrates how different data sources can contribute to and assist phase I trial designs. Single-drug and drug combination toxicity and pharmacokinetic data were primarily reviewed from several databases. We focused on the MTD, dose-limiting toxicity (DLT), toxicity, and pharmacokinetic profiles. To demonstrate the feasibility and utility of these data sources in improving trial designs, phase I studies reported in ClincalTrials.gov from January 1, 2018 to December 31, 2018 were used as examples. We evaluated whether and how these studies could have been designed differently given toxicity and pharmacokinetic data. None of the existing pharmacokinetic and toxicity databases contain either MTD or DLT. Among 268 candidate trials, four drug combinations were studied in other phase I trials before 2018; 185 combinations had complete or partial information on drug interactions or overlapping toxicity, and 79 combinations did not have available information. Two drug combination trials were selected as case studies. The nivolumab-axitinib trial could have been designed as a dose deescalating study, and the vinorelbine-trastuzumab emtansine trial could have been designed with a lower dose of either drug. Public data sources contain significant knowledge of the drug combination phase I trial design. Some important data (MTD and DLT) are not available in existing databases but in the literature. Some phase I studies could have been designed more efficiently with additional preliminary data.Significance:Prior preclinical and clinical knowledge is critical for designing effective and efficient cancer drug combinatory trials. We reported results on the feasibility and utility of different informatics resources for contributing to and assisting phase I trial designs based on our designed classification approach. We also found that public data sources contained significant knowledge for drug combination phase I trial design, but some critical data elements (MTD and DLT) were missing.
Information Theory–based Compositional Distributional
Semantics
Authors: Amigó Enrique , Ariza-Casabona Alejandro , Fresno Victor , Martí M. Antònia 
Published: August 2022

Abstract
In the context of text representation, Compositional Distributional Semantics models aim to fuse the Distributional Hypothesis and the Principle of Compositionality. Text embedding is based on co-ocurrence distributions and the representations are in turn combined by compositional functions taking into account the text structure. However, the theoretical basis of compositional functions is still an open issue. In this article we define and study the notion of Information Theory–based Compositional Distributional Semantics (ICDS): (i) We first establish formal properties for embedding, composition, and similarity functions based on Shannon’s Information Theory; (ii) we analyze the existing approaches under this prism, checking whether or not they comply with the established desirable properties; (iii) we propose two parameterizable composition and similarity functions that generalize traditional approaches while fulfilling the formal properties; and finally (iv) we perform an empirical study on several textual similarity datasets that include sentences with a high and low lexical overlap, and on the similarity between words and their description. Our theoretical analysis and empirical results show that fulfilling formal properties affects positively the accuracy of text representation models in terms of correspondence (isometry) between the embedding and meaning spaces.
Hybridization of Evolutionary Operators with Elitist Iterated Racing for the Simulation Optimization of Traffic Lights Programs
Authors: Cintrano Christian , Ferrer Javier , López-Ibáñez Manuel , Alba Enrique 
Published: August 2022

AbstractIn the traffic light scheduling problem, the evaluation of candidate solutions requires the simulation of a process under various (traffic) scenarios. Thus, good solutions should not only achieve good objective function values, but they must be robust (low variance) across all different scenarios. Previous work has shown that combining IRACE with evolutionary operators is effective for this task due to the power of evolutionary operators in numerical optimization. In this article, we further explore the hybridization of evolutionary operators and the elitist iterated racing of IRACE for the simulation–optimization of traffic light programs. We review previous works from the literature to find the evolutionary operators performing the best when facing this problem to propose new hybrid algorithms. We evaluate our approach over a realistic case study derived from the traffic network of Málaga (Spain) with 275 traffic lights that should be scheduled optimally. The experimental analysis reveals that the hybrid algorithm comprising IRACE plus differential evolution offers statistically better results than the other algorithms when the budget of simulations is low. In contrast, IRACE performs better than the hybrids for a high simulations budget, although the optimization time is much longer.
Looking at Anxiety from the Eyes of Domestic Workers: The Covid-19 Pandemic of 2020 Experience in Istanbul
Authors: Parlak Simel , Çelebi Çiğdem Demir , Yaman Neslihan 
Published: August 2022

Abstract
In this phenomenological study, it was attempted to carry out an in-depth investigation of the anxiety experiences of domestic workers, who were working as housekeepers but could not continue their work life during the COVID-19 outbreak. Through this, it was aimed to reveal their experiences regarding the anxiety they experienced during the pandemic process. In this study, in which the criterion sampling method was used, semi-structured interviews were conducted with 16 domestic worker women between the ages of 30–42. The 4-step data analysis process in Giorgi’s descriptive phenomenology pattern was used in the analyses. The descriptive phenomenological analysis revealed five main themes that describe the participants’ experiences: i) anxiety symptoms, ii) financial difficulties, iii) interfamilial relationships, iv) uncertainty and v) emotions that accompany anxiety. The main themes obtained by this research were similar to the sources of anxiety, its components and the emotions accompanying anxiety mentioned in the literature. During the quarantine days, it was seen that the most intense emotion experienced by domestic workers was anxiety. Although the lockdown and unemployment experiences of each participant is unique, it was determined that the most important determinants of this were economic problems due to the lack of job security.
The Spirit (רוח) in the Book of Psalms
Authors: Martin Lee Roy 
Published: August 2022

Abstract
This survey of the Spirit’s activity examines all thirty-nine occurrences of the word רוח (‘spirit’) in the book of Psalms. The study of these texts suggests that although the Psalter presents neither an organized pneumatology nor a complete one, the Spirit is described as the agent of God’s life-giving power and as the administrator of God’s moral authority. As the agent of God’s life-giving power, the Holy Spirit creates all life and sustains all life. As administrator of God’s moral authority, the Holy Spirit saves, guides, sanctifies, and enacts judgment.
Dismembering Israel
Authors: Basdeo Hill A. Rebecca 
Published: August 2022

Abstract
The book of Judges vividly depicts the spiritual decline, violence, and lawlessness that directly results from Israel’s failure to hear Yhwh. Israel’s refusal to hear Yhwh’s voice leads to each generation becoming more perverted, more depraved, and more corrupted than the prior generation, resulting in complete disorder at the end of the book. The downward spiral into anarchy and the steady social and spiritual deterioration seen in the book of Judges closely correspond to the security, interests, and welfare of the women in the narrative. The spiritual disintegration caused by Israel’s progressive deafness to Yhwh’s voice is linked to the oppression, violence, and silencing of women’s voices in Israel. This article examines the stories of the Israelite female characters in Judges and argues that the stories of women are organized in such a way that they expose the downward spiral of Israel as a whole.
Brieftheorie und Briefe im Spiegel frühneuzeitlichen Disputierens
Authors: Marti Hanspeter 
Published: August 2022

Abstract
The topic of this contribution is the relationship between letter and disputation in Early Modern times. The main part of the text is about letter-writing theory as it was presented in textbook-like manner in Early Modern dissertations, especially regarding the influence of the art of writing as Christian Weise taught it. Another emphasis lies in the theory of how to compose letters of recommendation. Another part of the essay lists areas in which research would be desired. Firstly, the interpretation of letters, which were included as paratexts of dissertations and could be used as proof of performance. Secondly, disputation and dissertation as topics in Early Modern correspondences. The latter are an important source for disputation and erudition history.
“Daß er ein Freund, ein Vorbote, ein Diener der Humanität werde, wollen auch wir an unserm unmerklich kleinen Teile befördern.”
Authors: Schienke Christian 
Published: August 2022

Abstract
Johann Gottfried Herder’s Briefe zu Beförderung der Humanität are probably the clearest articulation of the utopian intention inherent in his philosophy of history. As a result of the changes in utopian thinking with the beginning of the Enlightenment, this intention aims at humane principles of behavior and life practices instead of an ideal state. At the same time, it urges historical efficacy under the condition of an increasingly skeptical naturalized anthropology. The utopian conditions intended by Herder are therefore no longer presentable in the textual pattern of literary utopia handed down from Thomas More. This possibility, however, is offered by a common convention of philosophical epistolary sequences: the staging of a fictional correspondence allows Herder to present a humane discursive practice that exemplifies the utopian conditions themselves.