bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postvaccination anti-S IgG levels predict anti-SARS-CoV-2 neutralising activity over 24 weeks in patients with RA
Authors: Schmiedeberg Kristin , Abela Irene A , Pikor Natalia Barbara , Vuilleumier Nicolas , Schwarzmueller Magdalena , Epp Selina , Pagano Sabrina , Grabherr Sarah , Patterson Angelica Brooke , Nussberger Madalina , Trkola Alexandra , Ludewig Burkhard , von Kempis Johannes , Rubbert-Roth Andrea 
Published: October 2022

ObjectivesTo correlate immune responses following a two-dose regimen of mRNA anti-SARS-CoV-2 vaccines in patients with rheumatoid arthritis (RA) to the development of a potent neutralising antiviral activity.MethodsThe RECOVER study was a prospective, monocentric study including patients with RA and healthy controls (HCs). Assessments were performed before, and 3, 6, 12 and 24 weeks, after the first vaccine dose, respectively, and included IgG, IgA and IgM responses (against receptor binding domain, S1, S2, N), IFN-γ ELISpots as well as neutralisation assays.ResultsIn patients with RA, IgG responses developed slower with lower peak titres compared with HC. Potent neutralising activity assessed by a SARS-CoV-2 pseudovirus neutralisation assay after 12 weeks was observed in all 21 HCs, and in 60.3% of 73 patients with RA. A significant correlation between peak anti-S IgG levels 2 weeks after the second vaccine dose and potent neutralising activity against SARS-CoV-2 was observed at weeks 12 and 24. The analysis of IgG, IgA and IgM isotype responses to different viral proteins demonstrated a delay in IgG but not in IgA and IgM responses. T cell responses were comparable in HC and patients with RA but declined earlier in patients with RA.ConclusionIn patients with RA, vaccine-induced IgG antibody levels were diminished, while IgA and IgM responses persisted, indicating a delayed isotype switch. Anti-S IgG levels 2 weeks after the second vaccine dose correlate with the development of a potent neutralising activity after 12 and 24 weeks and may allow to identify patients who might benefit from additional vaccine doses or prophylactic regimen.
End of life in general practice: trends 2009–2019
Authors: Bergman Tessa D , Pasman H Roeline W , Hendriksen Janneke MT , Onwuteaka-Philipsen Bregje D 
Published: October 2022

ObjectivesTo assess possible trends between 2009 and 2019 in the Netherlands of palliative care indicators: the provision of palliative care or treatment, hospitalisations in the last month before death, use of specialised palliative care services and place of death.MethodsThe study design was a repeated retrospective cross-sectional design with questionnaires filled in by general practitioners within a clustered sample of 67 Sentinel practices. Patients whose death was non-sudden, and thus could have received palliative care, between 1 January 2009 and 31 December 2019 were included in the study, resulting in 3121 patients.ResultsBetween 2009 and 2019, there is a significant increase in the number of people who receive palliative care or treatment alongside life-prolonging or curative treatment and the number of people who die at home, while the number of hospitalisations in the last month before death and the number of people dying in hospital shows a significant decrease. However, there is no trend in the involvement of specialised palliative care services or people receiving solely palliative care or treatment.ConclusionThis study suggests improvements in end-of-life care provided in primary care in the Netherlands. Trends coincided with increased attention to palliative care both in practice and policy. Yet, there is still considerable room for improvement as there is no significant increase in people solely receiving palliative care or treatment and the involvement of specialised palliative care services.
Towards a unified theory of the fundamental physical interactions based on the underlying geometric structure of the tangent bundle
Authors: Herrmann Joachim 
Published: October 2022

AbstractThis paper pursues the hypothesis that the tangent bundle (TB) with the central extended little groups of the SO(3,1) group as gauge group is the underlying geometric structure for a unified theory of the fundamental physical interactions. Based on this hypothesis as a first step, I recently presented a generalized theory of electroweak interaction (including hypothetical dark matter particles) (Herrmann in Eur Phys J C 79:779, 2019). The vertical Laplacian of the tangent bundle possesses the same form as the Hamiltonian of a 2D semiconductor quantum Hall system. This explains fractional charge quantization of quarks and the existence of lepton and quark families. As will be shown, the SU(3) color symmetry for strong interactions arises in the TB as an emergent symmetry similar to Chern–Simon gauge symmetries in quantum Hall systems. This predicts a signature of quark confinement as a universal large-scale property of the Chern–Simon fields and induces a new understanding of the vacuum as the ground state occupied by a condensate of quark–antiquark pairs. The gap for quark–antiquark pairing is calculated in the mean-field approximation, which allows a numerical estimation of the characteristic parameters of the vacuum such as its chemical potential, the quark condensation parameter and the vacuum energy. Note that a gauge theoretical understanding of gravity was previously achieved by considering the translation group T(3,1) in the TB as gauge group. Therefore, the theory presented here can be considered as a new type of unified theory for all known fundamental interactions linked with the geometrization program of physics.
Dynamics and statefinder analysis of a class of sign-changeable interacting dark energy scenarios
Authors: Arévalo Fabiola , Cid Antonella 
Published: October 2022

AbstractWe revise the dynamical properties of a class of cosmological models where the dark sector interacts through an interacting term that changes sign during evolution. In particular, we obtain the critical points and investigate the existence and stability conditions for cosmological solutions, describing radiation, matter and dark energy dominated eras. We find that all the studied models admit a stable critical point corresponding to an accelerated phase. We use background data to find the best fit parameters for one of the studied models, resulting in an interacting parameter with a definite sign within the $$1\sigma $$

1
σ

confidence level, consistent with the results of the dynamical system analysis. We compute the statefinder parameters and plot the $$r-q$$

r
-
q

and $$r-s$$

r
-
s

planes, where we observe different evolutionary trajectories for the interacting scenarios, allowing in this sense to discriminate among dark energy models.
Excitation functions of deuteron induced nuclear reactions on dysprosium targets for the production of the theranostic relevant isotopes of terbium
Authors: Colucci Michele , Carminati Stefano , Haddad Ferid , Nigron Etienne , Groppi Flavia , Manenti Simone 
Published: October 2022

AbstractThe physical properties of $${}^{149,152,155,161}$$

149
,
152
,
155
,
161

Tb enable their use in both diagnostic and therapeutic applications in the field of nuclear medicine. For this reason the optimization of the production routes of these radionuclides is of widespread interest in research. In this work, the feasibility of the production of $${}^{155}$$

155

Tb and $${}^{161}$$

161

Tb via the nuclear reactions induced by deuterons on dysprosium target with natural isotopic abundances has been discussed. The cross sections of $${}^{nat}$$

nat

Dy(d,x) reactions have been studied in the 12.5–32 MeV energetic range with the stacked-foil technique and the corresponding Thick Target Yields have been obtained. The presence of terbium and dysprosium contaminants ($${}^{156,160}$$

156
,
160

Tb, $${}^{155,157,159}$$

155
,
157
,
159

Dy) has been evaluated too.
Anthropometric Study of Proximal Radius in Below-Average Height Thai Women and Its Correlation with Commercially Available Radial Head Prostheses
Authors: LUENAM Suriya , TANTHAPRABHA Natpawee , KOSIYATRAKUL Arkaphat 
Published: October 2022

Background: Most radial head prostheses were designed in Western countries based on the anatomical characteristics of Western populations. We hypothesised that these prostheses are too large for below-average height Thai women. The objective of this study is to evaluate the anthropometric parameters of the proximal radius in such a population and its correlation with commercially available prostheses. Methods: Dominant elbows of 124 Thai women whose height was <155 cm were studied. Using the standard anteroposterior and lateral radiographic images, the head diameter and thickness, the distance between the articular surface and radial tuberosity, the narrowest intra-medullary canal diameter and the narrowest outer diameter of the radial neck were measured. Correlations between body height and each radiographic parameter were assessed using the Pearson correlation coefficient (PCC). The specifications of the commercial metallic radial head implants were reviewed and used to evaluate the relevant radiographic parameters. Results: Mean of the minimum and maximum head diameter was 18.54 ± 1.11 mm and 19.13 ± 1.17 mm, respectively; the thickness was 7.43 ± 0.69 mm, the distance between the articular surface and tuberosity was 19.05 ± 1.45 mm, the intra-medullary canal diameter was 7.63 ± 1.2 mm and the outer diameter of the radial neck was 11.13 ± 1.26 mm. There is a poor correlation between the participant’s height and each parameter (PCC ≤ 0.50). In 24.2% of the participants, the smallest size of prosthetic designs with a head diameter of 20 mm is larger than +2 mm in reference to minor diameter. The minimum prosthetic head thickness is greater than the average value of the participants in 12 out of 15 designs. One participant has an outer neck diameter smaller than the smallest stem diameter of three designs. Conclusions: Surgeons must be aware that commercially available radial head replacement implants may be too large for below-average height Thai women. Level of Evidence: Level IV (Prognostic)
Electronic Nicotine Delivery Systems: An Updated Policy Statement from the American Association for Cancer Research and the American Society of Clinical Oncology
Authors: Herbst Roy S. , Hatsukami Dorothy , Acton Dana , Giuliani Meredith , Moushey Allyn , Phillips Jonathan , Sherwood Shimere , Toll Benjamin A. , Viswanath Kasisomayajula , Warren Nicholas J.H. , Warren Graham W. , Alberg Anthony J. 
Published: October 2022

Abstract
Combustible tobacco use has reached historic lows, demonstrating the importance of proven strategies to reduce smoking since publication of the 1964 Surgeon General's report. In contrast, the use of electronic nicotine delivery systems (ENDS), specifically e-cigarettes, has grown to alarming rates and threatens to hinder progress against tobacco use. A major concern is ENDS use by youth and adults who never previously used tobacco. While ENDS emit fewer carcinogens than combustible tobacco, preliminary evidence links ENDS use to DNA damage and inflammation, key steps in cancer development. Furthermore, high levels of nicotine can also increase addiction, raise blood pressure, interfere with brain development, and suppress the immune system. The magnitude of long-term health risks will remain unknown until longitudinal studies are completed. ENDS have been billed as a promising tool for combustible tobacco cessation, but further evidence is needed to assess their potential efficacy for adults who smoke. Of concern, epidemiological studies estimate that approximately 15% to 42% of adults who use ENDS have never used another tobacco product, and another 36% to 54% “dual use” both ENDS and combustible tobacco. This policy statement details advances in science related to ENDS and calls for urgent action to end predatory practices of the tobacco industry and protect public health. Importantly, we call for an immediate ban on all non-tobacco-flavored ENDS products that contain natural or synthetic nicotine to reduce ENDS use by youth and adults who never previously used tobacco. Concurrently, evidence-based treatments to promote smoking cessation and prevent smoking relapse to reduce cancer incidence and improve public health remain top priorities for our organizations. We also recognize there is an urgent need for research to understand the relationship between ENDS and tobacco-related disparities.
Examining Stripes on a Herd of Zebras: Impact of Genomic Matching for Ultrarare Sarcomas in Phase 1 Clinical Trials (SAMBA 102)
Authors: Moyers Justin T. , Pestana Roberto Carmagnani , Roszik Jason , Hong David S. , Naing Aung , Fu Siqing , Piha-Paul Sarina , Yap Timothy A. , Karp Daniel , Rodon Jordi , Livingston Andy , Zarzour Maria Alejandra , Ravi Vinod , Patel Shreyaskumar , Benjamin Robert S. , Ludwig Joseph , Herzog Cynthia , Ratan Ravin , Somaiah Neeta , Conley Anthony , Gorlick Richard , Meric-Bernstam Funda , Subbiah Vivek 
Published: October 2022

Abstract

Purpose:
Recently, the Connective Tissue Oncology Society published consensus guidelines for recognizing ultrarare sarcomas (URS), defined as sarcomas with an incidence ≤1 per 1,000,000. We assessed the outcomes of 56 patients with soft tissue, and 21 with bone sarcomas, enrolled in Phase 1 trials.

Experimental Design:
In this Sarcoma-Matched Biomarker Analysis (SAMBA-102 study), we reviewed records from patients on Phase 1 trials at the University of Texas MD Anderson Cancer Center between January 2013 and June 2021.

Results:
Among 587 sarcomas, 106 (18.1%) were classified as URS. Fifty (47%) were male, and the median age was 44.3 years (range, 19–82). The most common subtypes were alveolar soft part sarcoma (ASPS), chordoma, dedifferentiated chondrosarcoma, and sclerosing epithelioid fibrosarcoma. Compared with common sarcomas, median OS was similar 16.1 months [95% confidence interval (CI), 13.6–17.5] versus 16.1 (95% CI, 8.2–24.0) in URS (P = 0.359). Objective response to treatment was higher in URS 13.2% (n = 14/106) compared with common sarcomas 6.9% (n = 33/481; P = 0.029). Median OS for those treated on matched trials was 27.3 months (95% CI, 1.9–52.7) compared with 13.4 months (95% CI, 6.3–20.6) for those not treated on matched trials (P = 0.291). Eight of 33 (24%) molecularly matched treatments resulted in an objective response, whereas 6 of 73 unmatched treatments (8.2%) resulted in an objective response (P = 0.024). Clinical benefit rate was 36.4% (12/33) in matched trials versus 26.0% (19/73) in unmatched trials (P = 0.279).

Conclusions:
The results demonstrate the benefit of genomic selection in Phase 1 trials to help identify molecular subsets likely to benefit from targeted therapy.
Sohlh2 Regulates the Stemness and Differentiation of Colon Cancer Stem Cells by Downregulating LncRNA-H19 Transcription
Authors: Zhang Ruihong , Zhang Xiaoli , Zhang Wenfang , Cui Weiwei , Xiao Yunling , Liu Lanlan , Zhi Sujuan , Feng Xiaoning , Liu Xuyue , Shen Ying , Chai Jie , Hao Jing 
Published: October 2022

Abstract

Colon cancer stem cells (CSC) are tumor-initiating cells that drive tumorigenesis and progression through self-renewal and various differentiation potency. Therefore, the identification of factors critical for colon CSC function is vital for the development of therapies. Sohlh2 belongs to the superfamily of bhlh transcription factors and serves as a tumor suppressor in several tumors. The role of Sohlh2 in CSCs remains unknown. Here we demonstrated that Sohlh2 was related to the inhibition of LncRNA-H19/miR-141/β-catenin signaling and led to the consequent suppression of colon CSC stemness and the promotion of colon CSC differentiation in vitro and in vivo. Moreover, Sohlh2 could directly bind to the promoter of LncRNA-H19 and repress its transcription activity. LncRNA-H19 mediated the effects of Sohlh2 on colon CSC stemness and differentiation. Clinically, we observed a significant inverse correlation between Sohlh2 and LncRNA-H19, β-catenin, Lgr5, CD133 expression levels, and positive correlation between Sohlh2 and MUC2, TFF2 expression in colon cancer tissues. Collectively, our findings suggest an important role of the Sohlh2/LncRNA-H19/miR-141/β-catenin pathway in regulating colon CSC stemness and differentiation, suggesting potential therapeutic targets for colon cancer.

Implications:
This study identifies that Sohlh2 directly manipulates LncRNA-H19 transcription and suppresses the β-catenin signaling pathway and the Sohlh2/LncRNA-H19/miR-141/β-catenin signaling pathway plays an essential role in the stemness of colon CSCs.
An overview of genus Pteris L. in northeastern India and new report of Pteris amoena Blume from Arunachal Pradesh, India
Authors: Ashish K. Soni  , Vineet K. Rawat  , Abhinav Kumar  , A. Benniamin  
Published: October 2022

The present paper highlights a taxonomic account of genus Pteris L. (Pteridaceae E.D.M. Kirchn.) with newly reported species Pteris amoena Blume, which was collected from the Pange range of Tale Wildlife Sanctuary and Hapoli Primary Forest, Hapoli, Lower Subansiri District of Arunachal Pradesh. The present communication is based on plant exploration and in-depth surveys done by the first two authors and through scrutiny of herbaria and literature. All the species are enumerated in this list along with worldwide distribution (outside India), local distribution in Arunachal Pradesh, northeastern India as NEI included with other Indian states. Reported species shows some morphological closeness with P. terminalis Wall. ex. J.Agardh but differ in having bright pink axes and more rounded and crenately toothed segment-apices. All these characters differentiate to this species to its closely related species and testifying that P. amoena Blume as a new report to the Arunachal Pradesh. Detailed description, distributional range, ecology and specimen examined of newly reported taxa are provided in this paper.
The Fawcett’s Pierrot Niphanda asialis (Insecta: Lepidoptera: Lycaenidae) in Bandarban: an addition to the butterfly fauna of Bangladesh
Authors: Akash Mojumdar  , Dey Rajib 
Published: October 2022

Niphanda asialis de Nicéville, 1895 is a widely distributed butterfly that occurs from Assam (northeastern India) to Myanmar, Thailand, Laos, Vietnam and Yunnan. This species is “rare” in India (Kehimkar 2016) but it is moderately common in the Malayan region (Gogoi et. al 2016). Niphanda asialis (earlier known as Azanus asialis) was first described by de Nicéville (1895), based on a single collected specimen from Hofrath Dr. L. Martin.
No Mediation Effect of Telomere Length or Mitochondrial DNA Copy Number on the Association Between Adverse Childhood Experiences (ACEs) and Central Arterial Stiffness
Authors: Iannarelli Nathaniel J. , Wade Terrance J. , Dempster Kylie S. , Moore Jessy , MacNeil Adam J. , O'Leary Deborah D. 
Published: October 2022

Background
Adverse childhood experiences (ACEs) have been linked to increased cardiovascular disease (CVD) risk. Previous reports have suggested that accelerated biological aging—indexed by telomere length (TL) and mitochondrial DNA copy number (mtDNAcn)—may contribute to associations between ACEs and cardiovascular health outcomes. Here, we examine the potential mediating effects of TL and mtDNAcn on the association between ACEs and central arterial stiffness—an intermediate cardiovascular health outcome—as a novel pathway linking ACEs to CVD risk among young adults.

Methods and Results

One hundred and eighty‐five (n=102 women; mean age, 22.5±1.5 years) individuals provided information on ACEs. TL (kb per diploid cell) and mtDNAcn (copies per diploid cell) were quantified using quantitative polymerase chain reaction techniques. Central arterial stiffness was measured as carotid‐femoral pulse wave velocity (cfPWV; m/s). Multiple linear regression analyses were used to examine the associations between ACEs, TL, mtDNAcn, and cfPWV. ACEs were positively associated with cfPWV (
β
=0.147,
P
=0.035). TL (
β
=−0.170,
P
=0.011) and mtDNAcn (
β
=−0.159,
P
=0.019) were inversely associated with cfPWV. Neither TL (
β
=−0.027,
P
=0.726) nor mtDNAcn (
β
=0.038,
P
=0.620) was associated with ACEs. Neither marker mediated the association between ACEs and cfPWV.

Conclusions
An increasing number of ACEs were associated with a faster cfPWV and thus, a greater degree of central arterial stiffness. ACEs were not associated with either TL or mtDNAcn, suggesting that these markers do not represent a mediating pathway linking ACEs to central arterial stiffness.
Changes of Extreme High Temperature by Global Warming in the Northern Hemisphere
Authors: Cao Chenyu , Guan Xiaodan , Sun Wen , Guo Shuyang , Chen Bin 
Published: October 2022

Abstract
In recent decades, a high frequency of extreme high temperature has occurred in many regions worldwide, with serious impacts on society and the economy. As the temperature increases, the sensitivity of extreme high temperatures to changing thresholds in the northern midlatitudes exhibits a different performance response. The results of this study show that extreme high temperature in the increasing phase is more sensitive to changes in the threshold in both observations and simulations (the largest difference in the speed of temperature increase occurs at 3.5 and 25 days decade−1), primarily in North America and central Asia. However, an obvious discrepancy appears in the time series before 1980 and the spatial scale over North America between the Berkeley Earth Surface Temperature (BEST) and Hadley Centre Global Historical Climatology Network-Daily (HadGHCND) datasets. This finding highlights the fact that the old definition of being in the increasing temperature phase in modern climate history is problematic today. At the same time, when the old base period is selected, the frequency of extreme high temperatures will become a common event (close to 98% in a year) by 2100. Using 1961–90 as the base period is not suitable for calculating extreme temperatures in the future from the perspective of adapting to climate change. The increasing temperature threshold means there will be more frequent hot days, indicating that agriculture and species will be negatively affected, more wildfires will occur, and thus risks to humanity will increase.