bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dosimetric Evaluation of Dose Calculation Uncertainties for MR-Only Approaches in Prostate MR-Guided Radiotherapy
Authors: Coric Ivan , Shreshtha Kumar , Roque Thais , Paragios Nikos , Gani Cihan , Zips Daniel , Thorwarth Daniela , Nachbar Marcel 
Published: August 2022

Purpose: Magnetic resonance imaging guided radiotherapy (MRgRT) allows treatment plan adaptation on the MRI of the day. For dose calculations, a structure-specific bulk relative electron density (RED) overwrite derived from a planning computed tomography (CT) poses as one possible treatment workflow. However, this approach introduces uncertainties due to assignment of mean densities and requires a planning CT. The aim of this study was to investigate the uncertainty of the used patient-specific (PSCT) dose calculation in contrast to the correct calculation on a CT and compare to MR-only workflows using population-based bulk ED (PBCT) and artificial intelligence–based pseudo-CTs (AICT).Methods: Twenty primary prostate cancer patients treated on the 1.5 T MR-Linac were chosen from the clinical database, based on best visual congruence between the planning CT and daily MRI. CT-based reference dose distribution was compared to different pseudo-CT approaches. 1) For PSCT, mean REDs for the femur, pelvis, sacrum, rectum, bladder, and patient were assigned based on individual mean CT densities. 2) Population-based mean REDs were derived based on 50 previous, independent patients and assigned to the structures for the PBCT approach. 3) An AI model for pseudo-CT generation was trained using end-to-end ensembled self-supervised GANs and used to create AICTs from T2w-MRIs. For comparison, the CT was registered to the MRI, structures rigidly propagated, and treatment plans recalculated. Differences of DVH parameters were analyzed, and dose distributions were compared using gamma analysis.Results: All approaches were able to reproduce the dose distribution accurately, according to a gamma criterion of 3%/3 mm, with pass rates greater than 98%. Applying a 2%/2 mm criterion, the median gamma pass rates for PSCT, PBCT, and AICT resulted in 98.6%, 98.2%, and 99.0%, respectively. The median differences for PTV D98% resulted in 0.13 Gy for AICT, −0.31 Gy for PBCT, and −0.32 Gy for PSCT. The OAR-related DVH parameter showed similar results between the three investigated methods.Conclusion: In this study, a detailed analysis of uncertainties of MR-only treatment planning concepts for pelvic MRgRT was performed. Both a PBCT and an AICT approach, which bypass the need for a planning CT, may be considered clinically acceptable while reducing imaging dose and registration issues.
Use of concentric linear velocity to monitor flywheel exercise load
Authors: Martín-Rivera Fernando , Beato Marco , Alepuz-Moner Vicente , Maroto-Izquierdo Sergio 
Published: August 2022

Purpose: To propose the concentric linear velocity measurement as a valid method to quantify load and individualise the prescription of flywheel training, we investigated the relationship between inertial load and mean concentric linear velocity (MCLV) during the flywheel squat exercise in a wide spectrum of intensities. In addition, we compared MCLV and subjective rating of perceived exertion (RPE) after each load.Methods: Twenty-five physically active men volunteered for this study (26.5 ± 2.9 years, 179.5 ± 4.2 cm, 81.6 ± 8.6 kg). After familiarization, all participants performed two inertial progressive load tests on separated days to determine the flywheel load-velocity profile and its reliability. Each participant performed 5 set of 6 repetitions of the flywheel squat exercise with different inertial loads (0.047, 0.104, 0.161, 0.245, 0.321 kg m2) selected in a counterbalanced and randomized order for each testing day. Average MCLV and RPE for each load were compared.Results: The inter-session intraclass correlation coefficient (ICC) showed values above 0.9 in all the included outcomes (MCLV: ICC = 0.91; RPE: ICC = 0.93). A significant correlation (p &lt; 0.01, R2 = 0.80) between inertial load and MCLV was found. Similarly, significant correlation models (p &lt; 0.01) were observed between RPE and load (R2 = 0.87) and (R2 = 0.71) between RPE and MCLV.Conclusion: The control of MCLV during flywheel exercise can be proposed as a valid method to quantify load and to individualize the prescription of flywheel training. In addition, RPE responses have demonstrated significant correlations with load and velocity. Therefore, RPE has been proposed as a valid and reliable alternative to control flywheel training.
Soybean Crops Penalize Subsequent Wheat Yield During Drought in the North China Plain
Authors: Nie Jiangwen , Zhou Jie , Zhao Jie , Wang Xiquan , Liu Ke , Wang Peixin , Wang Shang , Yang Lei , Zang Huadong , Harrison Matthew Tom , Yang Yadong , Zeng Zhaohai 
Published: August 2022

Contemporary wisdom suggests that inclusion of legumes into crop rotations benefit subsequent cereal crop yields. To investigate whether this maxim was generically scalable, we contrast summer soybean–winter wheat (SW) with summer maize–winter wheat (MW) rotation systems in an extensive field campaign in the North China Plain (NCP). We identify heretofore unseen interactions between crop rotation, synthetic N fertilizer application, and stored soil water. In the year with typical rainfall, inclusion of soybean within rotation had no effect on wheat ear number and yield, while N fertilization penalized wheat yields by 6–8%, mainly due to lower dry matter accumulation after anthesis. In contrast, in dry years prior crops of soybean reduced the rate and number of effective ears in wheat by 5–27 and 14–17%, respectively, leading to 7–23% reduction in wheat yield. Although N fertilization increased the stem number before anthesis in dry years, there was no corresponding increase in ear number and yield of wheat in such years, indicating compensating reduction in yield components. We also showed that N fertilization increased wheat yield in MW rather than SW as the former better facilitated higher dry matter accumulation after flowering in dry years. Taken together, our results suggest that soybean inclusion reduced soil available water for subsequent wheat growth, causing yield penalty of subsequent wheat under drought conditions. We call for more research into factors influencing crop soil water, including initial state, crop water requirement, and seasonal climate forecasts, when considering legumes into rotation systems.
Graphical AbstractResponse of wheat population and yield to soybean inclusion under limited-irrigation.
Effects of negative life events on depression in middle school students: The chain-mediating roles of rumination and perceived social support
Authors: Xia Hui , Han Xuexue , Cheng Jing , Liu Debiao , Wu Yili , Liu Yan 
Published: August 2022

BackgroundNegative life events in middle school students have a significant impact on depression. However, the mechanism of this association is not fully understood. This study used rumination and perceived social support as mediating variables to explore the influence of negative life events on depression.Materials and methodsDue to the COVID-19 pandemic and social distancing, a convenient sampling method was adopted to collect information about middle school students in Shandong Province by means of online questionnaire. Adolescent Self-Rating Life Events Check List, Ruminative Responses Scale, Perceived Social Support Scale and Children’s Depression Inventory were used. Descriptive statistics and correlation analysis were conducted for four variables of middle school students, including life events, depression, rumination thinking and perceived social support, and the chain mediated effect was tested by using process plug-in. All statistically analysis was conducted by SPSS 23.0.Results493 middle school students (16.7000 ± 0.9500 years) including 343 female students (69.6000%) from Shandong Province recruited. Results showed that the total effect between life events and depression was significant (effect = 0.2535, 95%CI: 0.2146, 0.2924). The total indirect effect was significant (effect = 0.1700, 95%CI: 0.1349, 0.2072). The indirect effect was significant (effect = 0.0988, 95%CI: 0.0741, 0.1252) with rumination as the mediating variable. The indirect effect of pathway with perceived social support as the mediating variable was significant (effect = 0.0476, 95%CI: 0.0295, 0.0674). The indirect effect of pathway with rumination and perceived social support as mediating variables was also significant (effect = 0.0236, 95%CI: 0.0147, 0.0339).ConclusionThis study indicated that ruminant thinking and perceived social support had a significant chain mediating effect on adolescents’ life events and depression. Life events can not only directly affect depressive emotions, but also indirectly affect depressive emotions by affecting ruminant thinking and perceived social support. The results of this study not only provide new directions for the relationship between life events and depression, but also provide possible approaches for future prevention and intervention of depression in middle school students.
Development of a novel continuous measure of adolescent mental health inspired by the dual-factor model
Authors: King Nathan , Davison Colleen M. , Pickett William 
Published: August 2022

BackgroundAccording to the Dual-factor Model, mental health is comprised of two related constructs: subjective well-being and psychopathology. Combining these constructs can provide a more accurate and comprehensive assessment of adolescent mental health than considering either on its own. The model suggests the need to group mental health into four distinct categories, which does not recognize its potential continuum and adds statistical complexity. In this study, we developed a continuous measure inspired by, and as a complement to, the Dual-factor Model. Our goal was to demonstrate a novel approach to developing a valid measure for use in public health research that captures varying mental health states more accurately than traditional approaches and has advantages over the categorical version.MethodsSelf-report data are from the 2014 Canadian Health Behavior in School-aged Children study (n = 21,993). Subjective well-being was measured by combining indicators of life satisfaction, positive affect, and negative affect. Internalized and externalized symptoms scales were combined to measure psychopathology. The continuous dual-factor measure was created by subtracting standardized psychopathology scores from standardized subjective well-being scores. Construct validity was assessed using multivariable linear regression by examining associations between factors known to be associated with adolescent mental health status (demographic characteristics, social and academic functioning, and specific indicators of mental health) and average mental health scores.ResultsThe average age was 14.0 (SD = 1.41) years. The continuous mental health score ranged from 5 to 67 [Mean (SD): 50.1 (9.8)], with higher scores indicating better overall mental health. The nature and direction of the associations examined supported construct validity. Being from a more affluent family, and having more supportive relationships with family, peers, teachers, and classmates was associated with greater mental health (Cohen’s d: 0.65 to 1.63). Higher average marks were also associated with better mental health. Average mental health scores were much lower if students reported feeling hopeless or rated their health as fair or poor.ConclusionA continuous measure of mental health based on the Dual-factor Model appears to be a comprehensive and valid measure with applications for research aimed at increasing our understanding of adolescent mental health.
Psychological effects and associated factors among vaccinated and unvaccinated general population against COVID-19 infection in Bangladesh
Authors: Alam Md. Dhedharul , Abedin Md. Joynal , Islam Asraful , Mosfeq-Ul-Hasan Md. , Rahman Obaydur , Xu Yi 
Published: August 2022

BackgroundThe global effort to develop herd immunity in the general public against the COVID-19 pandemic is currently ongoing. However, to the best of our knowledge, there have been no studies on how the COVID-19 vaccine affects mental health in the context of the COVID-19 pandemic in Bangladesh. The present study investigated the psychological effects and associated factors among vaccinated and unvaccinated general populations against COVID-19 infection in Bangladesh.MethodsA nationwide online cross-sectional survey was conducted in Bangladesh from June 23 to December 25, 2021. The frequency of symptoms of psychological distress, depression, anxiety, stress, post-traumatic stress disorder (PTSD), insomnia, and fear was assessed using the Bangla versions of the GHQ-12, PHQ-2, GAD-2, PSS-4, PC-PTSD-5, ISI, and FCV-19S scales, respectively.ResultsThe study included 3,013 persons from all eight divisions of Bangladesh, with 1,272 (42.2%) being vaccinated and 1,741 (57.8%) being unvaccinated. Compared with unvaccinated populations, vaccinated populations had significantly lower prevalence rates of psychological distress (36.4 vs. 51.5%), depression (21.1 vs. 37.9%), anxiety (25.1 vs. 44.9%), stress (19.4 vs. 30.4%), PTSD (29.4 vs. 38.3%), insomnia (18.7 vs. 39.4%), and fear symptoms (16.1 vs. 27.5%). Among vaccinated populations, respondents who lived in nuclear families were significantly associated with higher risk of psychological distress (AOR, 1.38; 95% CI, 1.09–1.78), depression (AOR, 1.49; 95% CI, 1.11–1.98), anxiety (AOR, 1.77; 95% CI, 1.21–1.98), and fear (AOR, 1.43; 95% CI, 1.11–1.83) symptoms. Participants who lost family members, friends, or colleagues due to the COVID-19 pandemic had significantly higher risk of symptoms of psychological distress (AOR, 1.35; 95% CI, 1.02–1.79), anxiety (AOR, 1.41; 95% CI, 1.11–1.87), and PTSD (AOR, 1.76; 95% CI, 1.24–2.19). On the other hand, unvaccinated populations who lived in the Dhaka division were significantly associated with an increased risk of depression (AOR, 2.06; 95% CI, 1.40–2.52), anxiety (AOR, 1.86; 95% CI, 1.15–2.47), stress (AOR, 1.92; 95% CI, 1.12–2.88), and insomnia (AOR, 1.88; 95% CI, 1.20–2.94) symptoms. Except for PTSD and fear symptoms, unemployed participants had considerably higher rates of psychological distress, depression, anxiety, stress, and insomnia symptoms (e.g., psychological distress: AOR, 1.83; 95% CI, 1.10–2.62; depression: AOR, 1.74; 95% CI, 1.37–2.19).ConclusionsThis study recommends immunizing unvaccinated populations as soon as possible to prevent infection and boost mental health. Vulnerable people needed special care, health-related education, and psychological assistance.
Implementation of a shared decision-making training program for clinicians based on the major depressive disorder guidelines in Japan: A multi-center cluster randomized trial
Authors: Takaesu Yoshikazu , Aoki Yumi , Tomo Yui , Tsuboi Takashi , Ishii Miho , Imamura Yayoi , Tachimori Hisateru , Watanabe Koichiro 
Published: August 2022

BackgroundAlthough shared treatment decision-making with patients requires attention, it is not widely implemented, particularly in the field of psychiatry. The aim of this study was to assess whether a shared decision-making (SDM) training program for clinicians based on the major depressive disorder (MDD) guidelines improved the perceived involvement of the decision process for patients with MDD.MethodsA multi-center cluster-randomized controlled intervention of a clinician training program based on the Japanese MDD guidelines using related decision aids compared to usual care was conducted among 56 clinicians from 23 institutions. A total of 124 patients with MDD were enrolled in this study. The primary outcomes were the scores of the Shared Decision Making-Questionnaire-9 (SDM-Q-9) and Decision Conflict Scale (DCS) after the first visit to the outpatient clinics. The secondary outcomes were patients’ satisfaction, quality of life, trust in clinicians, and depressive symptoms. Additionally, we evaluated all the observed outcomes at the first and third months of follow-up.ResultsThe scores of the SDM-Q-9 in the SDM training program group were significantly higher than those in the control group at the first visit. However, no significant difference in the DCS scores was found between the two groups. There was no intervention effect for secondary outcomes and the outcomes at the first- and third-month follow-up visits.ConclusionThe clinician training program based on the Japanese MDD guidelines can be useful for implementation of SDM. Additional research is needed to confirm the efficacy of this SDM training program.Clinical trial registration[https://www.umin.ac.jp/], identifier [UMIN000034397].
Associations between reading and writing postures and myopia among school students in Ningbo, China
Authors: Jiang Danjie , Shi Bijun , Gao Hua , Guo Yanbo , Zhou Shaoying , Zhang Yan 
Published: August 2022

BackgroundWe conducted this study to investigate the prevalence of myopia among school students in Ningbo and to explore the associations between reading and writing postures and myopia.MethodsA population-based and cross-sectional study was conducted, and 3,256 school students aged 8–19 years were recruited. Each enrolled subject was assessed for uncorrected distance visual acuity (UDVA) using a standard logarithmic visual acuity E-chart and a non-cycloplegic autorefraction examination. Self-administered questionnaires were used to investigate myopia-related reading and writing postures and behavioral habits among school students.ResultsThe prevalence of myopia among primary school, middle school, and high school students was 61.49, 81.43, and 89.72%, respectively. Regarding the associations between reading and writing postures and myopia, we identified that a reading distance &gt;33 cm is a protective factor for myopia in female students [odds ratio (OR) = 0.31, 95% confidence interval (CI) = 0.15–0.64], in both primary school (OR = 0.55, 95% CI = 0.30–0.99) and middle school (OR = 0.37, 95% CI = 0.15–0.90).ConclusionsA reading distance &gt;33 cm can be used as an additional measure to prevent and control myopia. Proper postural measures for reading and writing may have educational and public health benefits.
Cognitive functions and anxiety among blue-collar workers in hospitals during COVID-19 pandemic
Authors: Mohammadi Abbas , Ibrahimi Ghavamabadi Leila , Silavi Maryam , Dehaghi Behzad Fouladi 
Published: August 2022

BackgroundThe rapid spread of COVID-19 poses a major threat to public health worldwide. Hospital blue-collar workers, like other health care workers, may be under severe physical and psychological stress. This psychological distress is mainly described as symptoms of anxiety and depression, stress and cognitive function. This study aimed to investigate the effects of anxiety on cognitive function among laundry and sterilization center workers in 4 hospitals during COVID-19 pandemic.MethodThis study has a cross-sectional design and it was conducted among health service workers who were occupied in health facilities (laundry and sterilization center) in 4 hospitals. In the present study, two questionnaires and a test were used to collect the data included a general health questionnaire (GHQ-28), a health anxiety index questionnaire (HAI-18) and a cognitive function test. Descriptive statistics and Spearman correlation coefficient by SPSS version 19 were used.ResultsThe results showed that the overall score of coronavirus anxiety in male and female workers was 38.72 ± 5.94 and 40.92 ± 4.11, respectively. The correlation between auditory attention and coronavirus anxiety is moderate and has a negative trend (P = 0.050, n = 50, and r = −0.315). Workers with higher anxiety expressed lower auditory attention. Also, correlation between visual attention and coronavirus anxiety was weak and negative (P = 0.032, n = 50, and r = −0.179).ConclusionThis study revealed that cognitive and psychological aspects of mental health can be affected by COVID-19 exposure and its due anxiety in blue-collar workers in hospitals. These findings indicate that purposeful supportive interventions should be implemented to promote workers' health and cognitive function.
A qualitative analysis of free text comments of participants from a massive open online mindfulness course
Authors: Neate Sandra L. , Reece Jeanette C. , Hassed Craig , Chambers Richard , Connaughton Sherelle , Nag Nupur 
Published: August 2022

IntroductionMindfulness-based interventions are associated with improved health and wellbeing. Online mindfulness interventions offer potential scalability and cost advantages over face-to-face interventions. However, little is known about the experiences of learners, what they identify as being helpful to developing a practice of mindfulness and what outcomes they experience from undertaking an online mindfulness program.MethodsThe Mindfulness for Wellbeing and Peak Performance Massive Open Online Course is a 4-week mindfulness program which includes psychoeducation, mindfulness meditation, applications and moderated discussion forums. Of the 3,335 participants who completed the March 2020 course, 527 (16%) responded to the final forum which invited participants to describe the highlights of the course. In order to enhance understanding of participant experiences and perceived outcomes of undertaking the course, a qualitative analysis of these free text comments was conducted using reflexive thematic analysis.ResultsTwo overarching themes were identified: (1) internal mechanisms of developing mindfulness (subthemes: paying attention to the present moment, learning to let go and find acceptance, cultivating an attitude of gentleness, and learning through a sense of belonging) and (2) the translation of mindfulness into daily living (subthemes: mindfulness being a support to mental wellbeing, learning to deal with uncertainty and adversity, living a more conscious life, a greater connection with self and others and channeling attention into productivity).DiscussionThe themes and subthemes provided insights into the mechanisms learners used to develop mindfulness and how they translated mindfulness into their lives in a variety of beneficial ways. This understanding of learners' experiences could inform delivery of future online mindfulness interventions.