bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mometasone furoate nasal spray in Italian children with seasonal allergic rhinitis: a comprehensive assessment
Authors: Indolfi Cristiana , Dinardo Giulio , Rosaria Umano Giuseppina , Klain Angela , Contieri Marcella , Decimo Alberto , Decimo Fabio , Ciprandi Giorgio , Del Giudice Michele Miraglia 
Published: September 2022

Objective: Seasonal allergic rhinitis (SAR) is a common disease of childhood and is characterized by type 2 inflammation, bothersome symptoms, and impaired quality of life (QoL). Intranasal corticosteroids are effective medications in managing SAR. In addition, mometasone furoate nasal spray (MFNS) is a well-known therapeutic option. However, the literature provided no data about the effects of MFNS in European children with SAR. Thus, this study addressed this unmet requirement.
Methods: MFNS was compared to isotonic saline. Both treatments were prescribed: one drop of spray per nostril, twice a day, for 3 weeks. Nasal cytology, total symptom score (TSS), visual analogic scale concerning the parental perception of severity of symptoms, and the Pediatric Rhinoconjunctivitis Quality of Life Questionnaire (PRQLQ) were assessed at baseline, after 7 and 21 days, and 1 month after discontinuation.
Results: MFNS significantly reduced eosinophil and mast cell counts, improved QoL, and relieved symptoms, as assessed by doctors and perceived by parents. These effects persisted over time, even after discontinuation. Both treatments were safe and well-tolerated.
Conclusions: The present study documented that a 3-week MFNS treatment was able to significantly dampen type 2 inflammation, improve QoL, and reduce severity of symptoms in Italian children with SAR, and was safe.
Management of Patients with Thyroid-Associated Ophthalmopathy: Role of Spectral Domain Optical Coherence Tomography
Authors: DAGDELEN Kenan , MUZ Ömer Ersin 
Published: September 2022

AIM: To demonstrate the changes in optic nerve head (ONH), retinal nerve fiber layer (RNFL) and macula in patients with thyroid-associated ophthalmopathy (TAO) by spectral domain optical coherence tomography (SD-OCT).
METHODS: We included forty-one eyes of 41 patients with a diagnosis of TAO and forty-eight eyes of 48 age- and sex-matched healthy subjects (control group) from June 2016 to July 2018. The ONH parameters, RNFL and macular thicknesses in the nine macular quadrants according to ETDRS were measured with SD-OCT. Proptosis level was determined by Hertel exophthalmometer. Clinical activity score (CAS) according to the European Group of Graves' Orbitopathy (EUGOGO) guidelines was determined in all patients.
RESULTS: Superior, inferior and average RNFL thicknesses were significantly lower in the TAO group compared to the control group (p < 0.05). Optic disc area was significantly larger in the TAO group. Outer quadrant macular thicknesses and average macular thickness were significantly lower in the TAO group (p < 0.05). CAS had a weak correlation with RNFL thickness and average macular thickness.
CONCLUSION: Alterations in RNFL thicknesses and macular thicknesses according to ETDRS template can be detected before the development of ocular symptoms in patients with TAO. OCT is a convenient, non-invasive tool for the evaluation and follow-up of macular structural changes. Patients can be diagnosed at an early stage prior to the development of functional damage. However, the low number of studies investigating this subject and the conflicting findings of existing studies necessitate further studies.
PEDIATRIC HEADACHES: DOES NEUROIMAGING CONTRIBUTE TO DIAGNOSIS?
Authors: ARSLAN Müjgan 
Published: September 2022

Objective
Headache is a common complaint in childhood.
While the etiology is usually benign, such as migraine
or tension-type headache, cranial imaging is often
performed on patients to identify any missed or serious
underlying pathology. In the present study we assess
the etiology and clinical characteristics of headaches
in children and establish the diagnostic contribution of
imaging methods.
Material and Method
This retrospective study included patients who
presented with headaches to the Pediatric
Neurology Outpatient Clinic of Süleyman Demirel
University Faculty of Medicine between 2019 and
2022. Headache information (frequency, duration,
type, characteristics, intensity, localization, and
accompanying findings) was obtained, and the cranial
imaging results of patients were recorded. Headaches
were classified according to the criteria established by
the International Headache Society.
Results
The study included 234 patients aged 2–18 years
with a mean age of 12.56 years, of which 64.5% were
female. The diagnosis was primary headaches in
68.4% of the patients, with tension-type headaches
in 46.2%, migraine in 31.2%, and other primary
headache causes in 22.5%. Among the secondary
headaches, disorders of the cranium, neck, eyes,
ears, nose, sinuses, teeth or other cervical structures
accounted for 79.7%, with the most common cause
being sinusitis. Cranial imaging was performed on
66.7% of the patients, of which 51.9% were identified
with abnormal findings. 14.1% of the imaging
results evaluated as abnormal were incidentally
detected cerebral abnormalities with potential clinical
significance; 10.3% were findings that were found
incidentally and had no clinical significance. The
treatment of these patients did not change with the
imaging result. Another 25% were evaluated as
extracerebral abnormality associated with headache.
Only one patient's outcome was associated with
headache. The patient was diagnosed with sinus vein
thrombosis and the treatment was arranged.
Conclusion
The majority of childhood headaches identified in
the present study were found to be benign, with the
leading causes being tension-type headache, infection
and migraine, and imaging methods were found to
be of little diagnostic benefit. It was concluded that
a detailed clinical assessment of patients presenting
with headaches could clarify the etiology, while
imaging methods may be useful in selected cases.
С. Н. Булгаков об институциональных основах экономической системы (к 150-летию со дня рождения)
Authors: Ипполитов Леонид Михайлович 
Published: September 2022

<p>В статье рассматривается религиозно-экономическая концепция институциональных основ социально-экономической системы С. Н. Булгакова.</p>
Challenge of Aesthetic Rehabilitation in Case of Fractured Anterior Teeth with Diastema and Gummy Smile
Authors: Mejri Oumayma , Kalghoum Imen , Farhat Yosra , Hadiji Mohamed amin , Hadyaoui Dalenda , Harzallah Belhssan , Cherif Mounir , Nouira Zohra 
Published: September 2022

The success of a restorative treatment in anterior teeth for a patient who lost dental aesthetic depends on the esthetic integration between soft tissues and hard tissues with less invasive procedure. (1/2)
The present available case report describes the esthetic management of gummy smile, fractured incisor teeth and midline diastema with a multidisciplinary approach of different specialties from diagnosis to treatment planning.Ceramic veneers and crowns yielded a good aesthetic and functional outcome.
Theatrical Activity as a Way of Developing Musical-Choreographic Competence in Future Preschool and Primary School Teachers
Authors: Pushkar Larysa , Lobova Olga , Pavlushchenko Nataliia , Parfilova Svitlana , Vasko Olha , Butenko Vita 
Published: September 2022

The article highlights the possibilities of applying elements of theatre arts in the process of preschool and primary school teachers professional training. In particular, it reveals the issue of forming musical and choreographic competence in students by means of various forms, types and methods of drama. The main forms of musical and choreographic competence formation in preschool and primary school teachers are practical and laboratory classes (disciplines “Pedagogy”, “Fundamentals of pedagogical creativity”, “Fundamentals of stage and screen art with teaching methods”, “Organization of theater activity in preschool education institutions”, “Methods of music education”, “Musical art with methods of teaching”, etc.) and extracurricular forms of students’ theater activity (drama societies, drama studios, etc.).
Important types of drama activities in the process of training future preschool and primary school teachers are staging and dramatization, within which it is advisable to use different methods of forming students’ musical and choreographic competence: music-motor and drama games, staging of fairytales and songs, improvisation on a given theme-image, sketches, etc. Their use contributes to the development of a holistic set of musical and choreographic abilities, formation of singing skills, stage and dance movements, upbringing of future teachers’ performance culture and so on.
Direct Anterior Approach in Hip Hemiarthroplasty for Femoral Neck Fractures: Do Short-Term Outcomes Differ with Approach?
Authors: Khan Irfan A. , Magnuson Justin A. , Arshi Armin , Krueger Chad A. , Freedman Kevin B. , Fillingham Yale A. 
Published: September 2022

Background:
Hip hemiarthroplasty (HA) is commonly used to treat femoral neck fractures, but it remains unclear if the surgical approach impacts patient outcomes for this commonly performed procedure. The objective of this systematic review and meta-analysis was to assess early postoperative outcomes in patients undergoing HA for femoral neck fracture with the direct anterior approach (DAA) compared with other approaches.

Methods:
The Cochrane Central Registry of Controlled Trials, MEDLINE, and Google Scholar databases were searched for randomized controlled trials, prospective nonrandomized trials, and retrospective studies published prior to September 7, 2021, comparing DAA with other approaches (anterolateral approach [ALA], direct lateral approach [DLA], and posterior-based approach [PA]) in HA for femoral neck fractures. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Outcomes included functional outcomes, total complications, prosthetic dislocation, periprosthetic fracture, periprosthetic joint infection (PJI), reoperation, mortality, pain, operative time, and perioperative blood loss. Fixed effect odds ratios, along with their 95% confidence intervals, were used to analyze dichotomous variables. Significance was set at p < 0.05. Meta-analysis was conducted with Review Manager 5.4.

Results:
In total, 19 studies were included for qualitative analysis and 16 studies were included for quantitative analysis, with a total of 1,604 cases analyzed (723 DAA, 215 ALA, 301 DLA, and 365 PA). Compared with other approaches, the use of the DAA for HA was associated with improved early postoperative functional outcomes, lower early postoperative pain scores, fewer total complications, and fewer prosthetic hip dislocations. The rates of periprosthetic fracture, PJI, and reoperation, pain scores beyond 40 days, operative time, perioperative blood loss, and mortality were not significantly different between surgical approaches.

Conclusions:
Utilizing the DAA while performing HA for femoral neck fractures is associated with improved functional outcomes, lower early postoperative pain scores, lower incidence of prosthetic hip dislocation, and potentially fewer total complications.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Long-term outcome and factors associated with restenosis after combination therapy of balloon angioplasty and stenting for symptomatic intracranial stenosis
Authors: Ueda Toshihiro , Takaishi Satoshi , Yoshie Tomohide , Usuki Noriko , Tatsuno Kentaro , Ohtsubo Haruki , Araga Takashi , Kaga Yasuyuki , Takada Tatsuro 
Published: September 2022

Abstract
Background The optimal treatment for intracranial artery stenosis (ICAS) has not been established. We retrospectively examined the initial and long-term outcomes associated with restenosis of a combination therapy of balloon angioplasty and stenting for symptomatic atherosclerotic ICAS.MethodsConsecutive patients who underwent balloon angioplasty and/or stenting for ≥ 70% ICAS between 2006 and 2020 were analyzed. Patients within 48 hours of stroke onset were excluded. The following procedures were established as standards at our institution: (1) primary balloon angioplasty alone was initially performed; (2) stenting for insufficient dilatation, recoiling, or dissection was conducted; and (3) stenting was considered for restenosis. Intracranial ischemic and hemorrhagic complications within 30 days after treatment were used to evaluate periprocedural safety. Recurrent ischemic events, restenosis and restenosis related factors were used to be evaluate the long-term outcome.ResultsA total of 160 patients were recruited. Initial treatment consisted of balloon angioplasty (n = 101) and stenting (n = 59). Intracranial complications within 30 days after treatment were ischemic in five (3.1%) and hemorrhagic in four patients (2.5%). The incidence of these complication was 3.1% in the stenting group and 2.5% in the balloon angioplasty group. The mean follow-up period was 53.9 months. Restenosis was found in 42 patients (26%). Recurrent ischemic events during follow-up were noted in 14 patients (8.8%), of which six patients had TIA and eight patients had ischemic stroke. Restenosis-associated factors included diabetes, coronary artery disease, percent stenosis after treatment, and balloon angioplasty in logistic univariate analysis. Multivariate Cox regression analysis showed that diabetes (HR: 2.084, CI: 1.039-4.180, p = 0.0386), length of lesion (HR; 1.358, CI: 1.174-1.571, p < 0.0001), and balloon angioplasty (HR: 4.194, CI: 1.083-16.239, p = 0.0379) were independent predictors for restenosis. ConclusionCombination therapy of balloon angioplasty and stenting for symptomatic ICAS had a low perioperative stroke rate and may improve long-term outcome. Balloon angioplasty, diabetes, and length of lesion were significantly associated with restenosis.
Analysis of Risk Factors of Death among Breast Cancer Patients in Ethiopia: Parametric shared frailty model
Authors: Yismaw Dessie , Desyebelew Belay 
Published: September 2022

Abstract
Breast cancer is the most frequently occurring cancer next to cervical cancer in both developed and developing countries with high risk in developed countries and low risk in developing countries. The main objective of the study is to investigate the risk factors, median survival time, compare the survival curves, compare the performance of AFT and parametric frailty models in modeling survival time of breast cancer patients. A retrospective study was employed on 392 breast cancer patients registered from 2013-2018 in University of Gondar and Felege Hiwot Referral Hospitals in northwest of Ethiopia. The median survival time of breast cancer patients who live in the urban and rural areas are 34 and 35 months, respectively. The family history of breast cancer has 0.643 times shortened survival time than no family history of breast cancer. The frailty of University of Gondar and Felege Hiwot Referral Hospitals were 0.536 (µ < 1) and 1.465 (µ > 1), respectively. The study employed multivariable lognormal-gamma shared frailty model and the results of the model revealed that age, weight, place of residence, tumor size, stage, number of estrogens, status of estrogen receptors, number of progesterone and family history of breast cancer are statistically significant factors which affect the survival time of breast cancer patients.
Effects of 5-aza-2'-deoxycytidine on DNA Methylation within Female Mouse Reproductive Tissues
Authors: Colwell Mathia , Flack Nicole , Medida Ramya Lekha , Drown Chelsea , Faulk Christopher , Mauro Laura 
Published: September 2022

Abstract
5-aza-2'-deoxycytidine (decitabine), is a chemotherapeutic DNA methyltransferase (DNMT) inhibitor widely used to treat myelodysplastic syndrome and acute myeloid leukemias. Decitabine’s anti-neoplastic activity is thought to result from inhibition of DNMTs leading to passive demethylation of 5’methylcytosines (5mC) in rapidly dividing tissues, resulting in cell death. However, we previously reported paradoxical effects on DNA methylation by decitabine in somatic tissues. Given the potential for lasting damage to DNA methylation in reproductive tissues from even short courses of decitabine in reproductive age humans, we chose to characterize its long-term effects here. Mice were treated with two clinically relevant doses of decitabine (0.15 mg/kg, 0.35 mg/kg) for 7 weeks and DNA methylation was assessed within female reproductive tract tissues. We found methylated cytosines within the ovary to be the least sensitive to decitabine exposure at both doses, whereas the uterus and the oviduct exhibited higher 5mC dysregulation, surprisingly biased towards hypermethylation at the 0.35 mg/kg dose. We identified the sites of differential methylation; revealing specific genes and pathways involved in cell differentiation, development, communication, and cell signaling that were universally altered in all tissues. In addition to our differential methylation data, we identified dysregulated transcription and pathways using RNAseq analyses. Overall, our findings show decitabine exposure causes an epigenetic insult to DNA methylation within female reproductive tissues. Our data provides evidence that further evaluation is needed to fully establish the long-term phenotypic effects post-decitabine exposure.
Industrial policy and labour productivity growth in Africa: Does the Technology Choice matter?
Authors: SIE Kouakou Jean Fidele 
Published: September 2022

Abstract
The persistent gaps in African sectoral labour productivity and the disappointing growth in the manufacturing and service sectors have revived interest among academics and policymakers. In search of ways to boost labour productivity, this study explores how the technology choice as a proxy for industrial policy can affect labour productivity growth. First, I identify the different sources of growth with the decomposition method of shift-share analysis and a recent dataset from 1960 to 2017 of nine sectors. Then I investigate the impact of comparative advantage development strategy on growth components (within effects and structural effects). The shift and share decomposition analysis results suggest a changing role of growth components. While the structural change effect is driven by the "static gains" still plays an important role, the within effect has been more prevalent during the MDGs and SDGs period. The empirical results indicate that defying comparative advantage hinders the within effect component mitigated by a weak and positive dynamic effect component. The evidence emphasises the design of industrial development based on the comparative advantage in SSA, complemented with policies and strategies aiming at increasing labour productivity in the agriculture sector due to its large employment share.
Differences in Negative Affect Among Current and Former Smokers with and without a Cancer Diagnosis
Authors: Pebley Kinsey , Krukowski Rebecca A , Murphy James G 
Published: September 2022

Abstract
Purpose: Smoking poses significant health risks for individuals diagnosed with cancer. However, trials aimed at increasing smoking cessation among individuals with cancer have largely been unsuccessful and cessation rates remain low. Mental health concerns such as depression, anxiety, and stress interfere with successful smoking cessation in the general population, but it remains unclear if this is true among those with cancer. The current study assessed differences between current and former smokers with and without cancer to determine if there are differences in depression, anxiety, and stress that may need to be targeted in future cessation interventions among cancer patients. Methods: Participants (N = 203) completed an online survey about demographic characteristics, cigarette use, depression, anxiety, and stress. Results: Current smokers with cancer had higher depression (B = 2.66, SE = 1.29, p = .04), anxiety (B = 7.02, SE = 2.83, p = .01), perceived stress (B = 4.34, SE = 1.77, p = .01), and cancer-related stress (B = 12.25, SE = 4.71, p = .01) scores compared to former smokers with cancer. Current smokers with cancer had higher anxiety scores (B = 6.28, SE = 2.70, p = .02) than current smokers without cancer. Conclusions: The current study may help to inform future cancer-specific cessation intervention development to improve cessation rates and health outcomes.Implications for Cancer Survivors: Better understanding how negative affect may impact smoking cessation among those with cancer may impact length and quality of life, and addressing these issues may improve overall outcomes among survivors.
Dynamic features of non-return mechanism in hatch door of amphibious aircraft
Authors: Wang Yanzhong , Dou Delong , Zhang Zhen 
Published: September 2022

Abstract
Non-return mechanism is the key device that plays the role of braking in the opening and closing electric actuator of amphibious aircraft hatch door, in which there are two core components, namely ball-and-socket contact pair and multi-disc friction pair. The braking response characteristics of non-return mechanism directly determine the performance and operation safety of the hatch door. In this paper, the dynamic model of non-return mechanism is established considering the freedom of rotation-translation. Based on MATLAB/Simulink, the solution framework of the overall dynamic model is built. The dynamic response characteristics of non-return mechanism in the process of reverse load braking, forward load braking and continuous closing are analyzed. The braking time and the angular displacement of the output shaft in the braking phase have been presented. The simulation demonstrates that three pairs of friction pairs can realize effective braking under the given working conditions. Compared with the forward load braking, the reverse load braking has longer braking time and smaller angular displacement of the output shaft. This study provides a theoretical basis for the design and optimization of non-return mechanism.
Measuring appearance-related comparisons: Validation of the Comparison Standards Scale for Appearance
Authors: Morina Nexhmedin , McCarthy Peter , Meyer Thomas , Schlechter Pascal 
Published: September 2022

Abstract
Background Humans constantly compare their attributes to different reference frames. According to the theoretical framework of the general comparative-processing model, such comparisons may be perceived as aversive (i.e., appraised as threatening the motives of the comparer) or appetitive (i.e., appraised as consonant with, or positively challenging the motives). However, we lack a measure that adequately captures multi-standard comparisons. Methods Considering appearance-related comparisons as a relevant comparison domain, we introduce the Comparison Standards Scale for Appearance (CSS-A) that assesses appearance-related social, temporal, counterfactual, criteria-based, and dimensional upward and downward comparisons regarding their a) frequency, b) perceived discrepancy, and c) engendered affect. We administered the CSS-A to 1121 participants, along with measures of appearance social comparison, body satisfaction, physical self-concept, self-esteem, well-being, and depression.Results A two-factor model (aversive and appetitive comparisons) fit the data better than a bifactor model with an additional general domain-factor (comparative thinking). The validity of the CSS-A was supported by correlations with external validators beyond appearance, social comparison, and body satisfaction. Aversive comparisons displayed higher associations with most outcomes than appetitive comparisons. Conclusions Overall, the CSS-A offers a psychometrically sound and useful measure of multi-standard comparisons.