bluuebunny/crossref_metadata_2025_split huggingface dataset:
Five‐year recurrence pattern of mature cystic teratoma according to operation type in young women
Authors: Park Chan‐Hong , Kim Soo‐Min , Kim Sung Eun , Lee Dong‐Yun , Choi Doo Seok 
Published: June 2022

AbstractObjectiveTo find cumulative recurrence rate and risk factors for recurrence in young women with mature cystic teratoma (MCT).MethodsPatients aged 10–29 years with MCT confirmed by their first ovarian surgery between 2000 and 2018 were included in the study. To rule out residual lesions, only patients with no MCT‐suspected lesions on imaging within 1 year after surgery were included in the study. Patients who had not undergone imaging tests from 1 year after surgery or had other findings on biopsy were excluded.ResultsThe present study included 372 (84.2%) patients with cystectomy and 70 (15.8%) patients with oophorectomy. The 5‐year cumulative recurrence rates for each patient group were 11.2% and 20.3%, respectively. The hazard rate of recurrence was higher in the oophorectomy group than the cystectomy group within 5 years after surgery. Large tumor size (hazard ratio [HR] 2.59; 95% confidence interval [CI] 1.11–6.08) and bilaterality (HR 2.65; 95% CI 1.27–5.52) were significant predictors of recurrence in the cystectomy group.ConclusionThe 5‐year cumulative recurrence rate after surgery in young women with ovarian MCT was 11.2% in the cystectomy group and 20.3% in the oophorectomy group. Risk factors for recurrence after cystectomy were large tumor size and bilaterality.
Evaluating Large Bank Risk Using Stock Market Measures in the Basel III Period
Authors: Song Guoxiang 
Published: June 2022

AbstractThere is a puzzle in the literature which seems to indicate that high capital levels introduced by Basel III increase bank risk. This paper attempts to solve this puzzle by investigating whether the risk of the eight U.S. global systemically important banks (GSIBs) increased in the Basel III period from previous periods. This paper uses case studies of the eight U.S. GSIBs to evaluate whether Basel III has changed their risk perceived by the market. Basel III has reduced the systematic risk of equity of U.S. GSIBs perceived by the stock market, and it does not explain the decline in return on equity (ROE) which may indicate some increase in large bank financial risk. The paper breaks down stock market measures into drivers which capture systematic risk of equity and other drivers which capture financial risk, and it finds new evidence which solves the puzzle in the literature on large bank risk. The findings of the paper help investors, creditors and regulators to have a clear understanding of the market perception of large bank risk. The paper provides new methods and evidence which could help regulators to assess the impact of Basel III on bank risk perceived by the market.
Epigenetic silencing of E‐cadherin gene induced by lncRNA MALAT‐1 in acute myeloid leukaemia
Authors: Huang Jinlong , Fang Jingping , Chen Qinchang , Chen Jinyuan , Shen Jianzhen 
Published: June 2022

AbstractBackgroundEpigenetic abnormalities in acute myeloid leukaemia provide us with a target for novel therapeutic strategies. The aim of the study was to verify the epigenetic regulatory mechanism of E‐cadherin gene silencing induced by long non‐coding RNA MALAT‐1 in AML.MethodsExpression of MALAT‐1, E‐cadherin, EZH2, SUZ12 and EED genes in AML patients was detected by RT‐qPCR. After MALAT‐1 silencing in AML cell lines, levels of the E‐cadherin, EZH2, SUZ12, EED, DNMT1, DNMT3A and DNMT3B genes and encoded proteins were detected by RT‐qPCR and Western blotting. The level of CpG island methylation and trimethylation modification of histone H3K27 in the promoter region of E‐cadherin was detected by pyrosequencing and ChIP‐qPCR. RIP‐qPCR was used to detect the interaction between MALAT‐1 and proteins.ResultsMALAT‐1, EZH2 and EED gene expression was markedly increased in AML patients with E‐cadherin down‐regulation. A positive correlation between EZH2 or SUZ12 and MALAT‐1 expression was observed. After MALAT‐1 silencing, the expression of E‐cadherin was up‐regulated, whereas the expression of EZH2, SUZ12, DNMT1, DNMT3A and DNMT3B was down‐regulated. Results of Western blotting were consistent with those of RT‐qPCR. Methylation levels of E‐cadherin in AML patients were higher than that in normal controls, which appeared to increase with age. Methylation of the CpG island and H3K27 trimethylation of E‐cadherin were decreased after MALAT‐1 silencing. RIP‐qPCR suggested that MALAT‐1 might be enriched by EZH2 and SUZ12.ConclusionOur findings verified that MALAT‐1 might lead to the transcriptional silencing of E‐cadherin gene through the trimethylation of H3K27 mediated by recruiting EZH2 and SUZ12.
Identification and molecular characterization of penicillin‐nonsusceptible Streptococcus pneumoniae isolates recovered from invasive infections in a pre‐pneumococcal vaccine era
Authors: Mosadegh Mehrdad , Habibi Ghahfarokhi Soheila , Ahmadi Ali , Pourmand Mohammad Reza , Erfani Yousef , Mashhadi Rahil 
Published: June 2022

AbstractBackgroundGiven the significant role of penicillin‐nonsusceptible Streptococcus pneumoniae in inducing severe infectious diseases, identifying serotypes and genotypes that can mediate antimicrobial resistance has become a pillar of treatment strategies. This study aims to determine the correlation between the minimum inhibitory concentration of antimicrobial agents and amino acid mutations in penicillin‐binding proteins. Moreover, molecular serotyping and multiple‐locus variable number tandem repeat analysis typing were first‐ever performed to characterize the invasive penicillin‐nonsusceptible S. pneumoniae isolates in Iran.MethodsOf 149 isolates, antimicrobial susceptibility tests were performed against penicillin, ceftriaxone, and cefotaxime by the MIC Test Strip, and sequence analysis of the pbp genes was performed through PCR‐sequencing method. All penicillin‐nonsusceptible S. pneumoniae isolates were serotyped and genotyped by sequential multiplex PCR and multiple‐locus variable‐number tandem repeat analysis, respectively.ResultsAmong pneumococcal isolates, 53 isolates were classified as penicillin‐nonsusceptible S. pneumoniae, of which 38 (71.7%) and 15 (28.3%) were resistant and intermediate to penicillin, respectively. Furthermore, ceftriaxone‐ and cefotaxime‐nonsusceptible pneumococci constituted 33 (62.2%) and 29 cases (54.7%), respectively. Of note, there were 8 and 41 different serotypes and multiple‐locus variable‐number tandem repeat analysis types, respectively.ConclusionsDue to the increasing resistance to antimicrobial agents, the most efficient approach to preventing pneumococcal infection mortality as vaccine‐preventable diseases is focusing on wide‐spectrum vaccination. Based on our findings, the 13‐valent pneumococcal conjugate vaccine could considerably reduce the incidence of invasive pneumococcal diseases due to the high rate of serotype coverage.
Service use and barriers to care among homeless veterans: Results from the National Veteran Homeless and Other Poverty Experiences (NV‐HOPE) study
Authors: Tsai Jack , Kelton Katherine 
Published: June 2022

AbstractThe objective of this study was to examine type of services U.S. veterans seek when they experience homelessness, characteristics associated with service use, and reasons for not using services. Data from a 2021 nationally representative survey of 1004 low‐income U.S. veterans were analyzed with descriptive and multivariable analyses. One‐quarter of low‐income U.S. veterans with experiences of homelessness reported using homeless services while they were homeless and about 27% reported using U.S. Department of Veterans Affairs (VA) healthcare or benefits while homeless. Black and Hispanic veterans were more likely to use both homeless services and VA services while homeless than veterans of other race/ethnic groups. The most common barriers to services were: veterans felt they did not need help, they did not have information about services, there was stigma and shame, and transportation barriers were encountered. These findings suggest veterans use various VA and community‐based homeless and healthcare services, but they do experience barriers that may be improved with better public information and care coordination to improve service uptake among homeless veterans.
Purification of creosol applying green heterogeneous extraction technology
Authors: Yin Junjun , Chen Xiaoqian , Wang Duo 
Published: June 2022

AbstractBACKGROUNDCresol is an important industrial raw material, which is mainly derived from lignocellulosic biomass. High‐purity creosol can significantly improve the quality of its downstream product. The extraction of creosol with ultra‐high purity (>99.5%) and low cost has attracted extensive attention in recent years. A new and simple green heterogeneous extraction technology for separating ultra‐high‐purity creosol is proposed in this paper.RESULTSWhen a certain amount of creosol is gradually dripped into Ca2+ solution, the chemicals in three reaction stages are successively monitored by in situ Fourier transform infrared spectroscopy. The molar ratio of creosol and Ca2+ in the end‐product of this reaction reaches four. Three different chemical bonds in three reaction stages are successively monitored: ion bond, coordination bond formed by ionic compound, and coordination bond formed by creosol molecule. This collected end‐product can be decomposed easily. The vapors released in this decomposed process is determined to be high‐purity creosol. Meanwhile, the molar ratio of creosol to Ca2+ in the residual solid after decomposition of the end‐product reduces to two.CONCLUSIONBased on the reaction mechanism between Ca2+ and creosol, a new route for the separation and purification of creosol was proposed in this study. The creosol extraction rate reached 91.5% when excessive Ca2+ solution was added to the creosol solution. The purity of creosol reaches up to 99.7% when the end‐product of the reaction between Ca2+ and creosol is decomposed at 170 °C. © 2022 Society of Chemical Industry (SCI).
Corrosion inhibition of hybrid H2QS/CaO additives for AA5052 alloy in alkaline solution
Authors: Yang Junyu , Zhang Daquan , Gao Lixin , Li Chunping 
Published: June 2022

AbstractBACKGROUNDThe parasitic H2 evolution reaction (HER) is the main problem preventing the development of the commercial Al‐air battery (AAB) in alkaline solution. The purpose of this study is to investigate a hybrid additive for alkaline AAB. The inhibition effect of the additives for HER is studied by hydrogen evolution test, electrochemical measurements, and scanning electron microscope (SEM). The stability of the battery and the anode utilization rate in alkaline solution are also investigated.RESULTSResults showed that the maximum inhibition efficiency was 86.52% for 0.08 g L−1 CaO + 0.5 mmol L−1 H2QS, and that the anode utilization rate increased to 90.7%. A spectrum analysis, including infrared, ultraviolet, and fluorescence, was conducted to analyze the corrosion inhibition mechanism. The chelation of the quinoline ring with Al3+ ions and the electrostatic interaction of sulfonic groups with Ca2+ ions produce a strong synergistic effect.CONCLUSIONThe hybrid H2QS/CaO additive has synergistic effects to help form a stable composite film that significantly retards the hydrogen evolution reaction of the Al alloy anode for the alkaline AAB. © 2022 Society of Chemical Industry (SCI).
Joost J. Oppenheim: 1934–2022
Authors: Wahl Sharon M , Young Howard A 
Published: June 2022

ABSTRACTJoost J. Oppenheim was born in 1934 in Venlo, Netherlands and died at the age of 87 on May 14, 2022. Not one to retire or rest on his laurels, Joe remained a Senior Investigator and Head of the Cellular Immunology Section in the Cancer Innovation Laboratory of the National Cancer Institute until his passing. In the years between 1934 and 2022, Joe lived a life filled with peril, poverty, persistence, brilliance, discovery, recognition, family and satisfaction. With Joe's passing comes the end of an era and the loss of a Father of Cytokine Research who was an amazing investigator, colleague, mentor and friend.
Recent development in foam‐mat drying process: Influence of foaming agents and foam properties on powder properties
Authors: Çalışkan Koç Gülşah , Tekgül Yeliz , Yüksel Ayşe Nur , Khanashyam Anandu Chandra , Kothakota Anjineyulu , Pandiselvam Ravi 
Published: June 2022

AbstractFoam‐mat drying is an alternative dehydration technique to tray, drum, freeze, and spray drying. Foam‐mat drying can be used to obtain high‐quality powders from fruit juices and other heat‐sensitive food products which are difficult to dry using traditional drying techniques. In foam‐mat drying, the product to be dried is first converted into a stable foam by whipping, bubbling, or shaking in the presence of a foaming agent and foam stabilizer. The foam has been significantly increased the surface area of the product and thereby decreasing the time, temperature, and cost needed for drying. The selection of a foaming agent, foam stabilizer, foaming technique, and drying method is crucial in determining the final quality of the dried product. Due to its simplicity, faster drying, cost‐effectiveness, and improved product quality, foam‐mat drying is getting attention from researchers and industrialists worldwide. In this context, this review aims to present an overview of the recent advances in foam‐mat drying along with its cost economics and industrial potential.
Risk of respiratory tract infections and serious infections in psoriasis patients treated with biologics: Results from the BioCAPTURE registry
Authors: van der Schoot Lara S. , Groenewoud Hans J. M. M. , van Gelder Marleen M. H. J. , Otero Marisol E. , Arnold W. Peter , Berends Maartje A. M. , De Bruin‐Weller Marjolein S. , Dodemont Sharon R. P. , Kleinpenning Marloes M. , Koetsier Marjolein I. A. , Kop Else N. , Körver John E. M. , Kuijpers Astrid L. A. , van Lümig Paula P. , Mommers Johannes M. , Njoo Marcellus D. , Ossenkoppele Paul M. , Tupker Ron A. , Visch M. Birgitte , Weppner‐Parren Lizelotte J. M. T. , de Jong Elke M. G. J. , van den Reek Juul M. P. A. 
Published: June 2022

AbstractBackgroundLimited real‐world studies are available comparing infection risk between biologics for psoriasis.ObjectivesThe primary aim was to determine the differential effect of currently available biologics on the risk of respiratory tract infections (RTI) among psoriasis patients in a real‐world setting. Secondary aims were to explore the differential risk of all types of serious infections (SI) between biologics and to provide an early overview of SARS‐CoV‐2 infections during the pre‐vaccine era.MethodsCrude incidence rates of RTI and SI were calculated per 100 patient‐years (PY) per biologic using prospective BioCAPTURE data. Negative Binomial Regression modeling was used to explore the risk of RTI. Frailty Cox proportional hazards modeling was used to estimate hazard ratios for the risk of the first SI. Confounders adjusted for both models were selected by a directed acyclic graph. A post hoc exploratory analysis of SARS‐CoV‐2 infection incidence rates during 2020 was performed.ResultsWe included 714 patients with 1325 treatment episodes (3607.7PY between 2005 and 2020), in which 2224 RTI and 63 SI occurred. Among RTI, 1.3% were serious. The crude incidence rates were 61.7 (95% confidence interval [CI]: 59.1–64.3) per 100PY for RTI, and 1.8 (95% CI: 1.4–2.2) per 100PY for SI. Confounder adjusted analyses showed no differential risk of RTI between adalimumab, etanercept, infliximab, ustekinumab, secukinumab, ixekizumab and guselkumab. For SI, no differential risk was found between biologics either. Extended single‐center data showed 3.8 (95% CI: 2.2–6.1) SARS‐CoV‐2 infections per 100PY in 2020.ConclusionsConfounder adjusted analyses showed no differential risks of RTI or SI between included biologics (adalimumab, etanercept, infliximab, ustekinumab, secukinumab, ixekizumab and guselkumab) in a prospective psoriasis patients cohort. In general, absolute numbers of all types of SI were low.
Effect of desmopressin on bleeding during endoscopic sinus surgery: A randomized clinical trial
Authors: Akbarpour Maliheh , Jalali Mir Mohammad , Akbari Maryam , Haddadi Soudabeh , Fani Ghaffar 
Published: June 2022

AbstractBackgroundThis study aimed to evaluate the effect of local nasal desmopressin premedication on blood loss and the quality of surgical field in Functional Endoscopic Sinus Surgery (FESS).Material and methodsIn a randomized clinical trial, patients referred for FESS to treat their bilateral chronic rhinosinusitis were recruited. The participants were adults (≥18 years). They were randomly assigned (1:1:1) to receive low‐dose (20 μg) or high‐dose (40 μg) intranasal desmopressin (DDAVP) or placebo 60 min before the induction of general anesthesia. Standard FESS was performed by the same surgeon. The primary outcomes were volume of intraoperative bleeding and the quality of surgical field. Clean surgical field was defined as a score ≤2 on the Boezaart grading system.ResultsA total of 120 patients were included on an intention‐to‐treat basis (mean age: 41.0 years; 40 women, 80 men). There were no significant differences in primary outcomes between low‐dose DDAVP and placebo. As for the volume of blood loss, however, there was a significant difference between high‐dose DDAVP and placebo (mean difference: 29.6 ml; adjusted Cohen's d: −1.02; p < .001). Also, in the high‐dose DDAVP, the probability of having a good surgical field over time was about two times higher than in the placebo group (RRs for first and second surgical sides: 1.89 and 2.18). The number needed to treat for the two time points was 1.6 and 1.3, respectively.ConclusionThe present study showed that the use of desmopressin at a dose of 40 μg 1 h before surgery can reduce bleeding and improve the quality of the surgical field. Further studies are recommended to be able to generalize these findings to other ENT surgeries.Level of evidence1b.
Montgomery‐Åsberg Depression Rating Scale factors in treatment‐resistant depression at onset of treatment: Derivation, replication, and change over time during treatment with esketamine
Authors: Borentain Stephane , Gogate Jagadish , Williamson David , Carmody Thomas , Trivedi Madhukar , Jamieson Carol , Cabrera Patricia , Popova Vanina , Wajs Ewa , DiBernardo Allitia , Daly Ella J. 
Published: June 2022

AbstractObjectiveDerive and confirm factor structure of the Montgomery‐Åsberg Depression Rating Scale (MADRS) in patients with treatment‐resistant depression (TRD) and evaluate how the factors evident at baseline change over 4 weeks of esketamine treatment.MethodsTwo similarly‐designed, short‐term TRANSFORM trials randomized adults to esketamine or matching placebo nasal spray, each with a newly‐initiated oral antidepressant, for 4 weeks (TRANSFORM‐1: N = 342 patients; TRANSFORM‐2: N = 223 patients). The factor structure of MADRS item scores at baseline was determined by exploratory factor analysis in TRANSFORM‐2 and corroborated by confirmatory factor analysis in TRANSFORM‐1. Change in MADRS factor scores from baseline (day 1) to the end of the 28‐day double‐blind treatment phase of TRANSFORM‐2 was analyzed using a mixed‐effects model for repeated measures (MMRM).ResultsThree factors were identified based on analysis of MADRS items: Factor 1 labeled affective and anhedonic symptoms (apparent sadness, reported sadness, lassitude, inability to feel), Factor 2 labeled anxiety and vegetative symptoms (inner tension, reduced sleep, reduced appetite, concentration difficulties), and Factor 3 labeled hopelessness (pessimistic thoughts, suicidal thoughts). The three‐factor structure observed in TRANSFORM‐2 was verified in TRANSFORM‐1. Treatment benefit at 24 h with esketamine versus placebo was observed on all 3 factors and continued throughout the 4‐week double‐blind treatment period.ConclusionsA three‐factor structure for MADRS appears to generalize to TRD. All three factors improved over 4 weeks of treatment with esketamine nasal spray.
Molecular design of monomers by considering the dielectric constant and stability of the polymer
Authors: Taniwaki Hiroaki , Kaneko Hiromasa 
Published: June 2022

AbstractThe dielectric constant (DC) and glass transition temperature (Tg) properties were used to design polymers by quantitative structure–property relationship (QSPR). Using polymer data sets that included homopolymers and copolymers, property prediction models were constructed using the polymer properties and molecular descriptors calculated from monomer structures. The best combination of regression methods, types of descriptors, and preprocessing methods for constructing regression models were determined, and thus, DC and Tg prediction models with a high prediction accuracy could be constructed. Then, theoretical monomer structures, and theoretical copolymers with different combinations of monomer structures and composition ratios were generated, and the DC and Tg of the generated structures were predicted using the constructed models. Candidate structures met the desired DC and Tg values, and the proposed method could select promising monomer structures and composition ratios. Thus, monomer structures that would produce polymers with a high or low DC and high Tg were designed.
A theoretical comparison of the electrical and nonlinear optical properties ofGDY–π–TPA: The important role ofπ‐conjugated bridge
Authors: Hou Na , Feng Ran , Fang Xiao‐Hui 
Published: June 2022

AbstractBased on the donor‐acceptor framework of graphdiyne–triphenylamine (GDY–TPA), eight GDY–π–TPA molecules were designed by introducing aπ‐conjugated bridge, including electron‐rich heterocycles, electron‐deficient heterocycles, and unsaturated hydrocarbons. The geometric structures, electronic characteristics, static nonlinear optical (NLO) properties, and frequency‐dependent HRS first hyperpolarizabilities were investigated employing the density functional theory (DFT) calculations. The charge population analysis reveals that electron‐rich heterocyclics and unsaturated hydrocarbons act as donors, whereas electron‐deficient heterocyclics can be regarded as acceptors, significantly increasing the first hyperpolarizabilities (β0) of GDY–π–TPA (except forB‐3). TheC‐1compound containing the vinyl unit is the best NLO model among all systems. The nature of the excellent NLO properties of the systems can be understood from the low excitation energy of the crucial excited state and the analysis of the first hyperpolarizability density. In addition, the varying order of static and dynamicβHRSvalues is consistent with those ofβ0values. Understanding the relationship between structure and nonlinear optical response can provide guidance for the theoretical design of NLO molecules.