bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in the formation of the contingent of students of the specialty 36.05.01 “Veterinary medicine” in russian universities
Authors: Akchurin S. V. , Dyulger G. P. , Akchurina I. V. , Bychkov V. S. , Latynina E. S. 
Published: January 2022

Relevance. The purpose of this study is to identify trends in the formation of the contingent of students in the specialty 36.05.01 “Veterinary medicine” in Russian universities in 2013–2020.Methods. The study used methods such as analysis, synthesis, source analysis. The main aspect of the study is the change in the number of students in the specialty 36.05.01 “Veterinary medicine” in Russian universities.Results. Based on the analysis and assessment of data on changes in the structure of the contingent of students in the specialty 36.05.01 “Veterinary medicine”, it is possible to draw conclusions about the presence of the following trends. 1. Increase in demand for educational program 36.05.01 “Veterinary medicine”. 2. Assistance from the state in increasing the availability of the educational program 36.05.01 “Veterinary medicine” by increasing the number of regions with the training of veterinarians and developing markets for full-time and part-time education. The increase in the admission target figures for these forms of education contributed to the more active development of these forms of education by universities and the attraction of citizens not only to budgetary, but also to paid places. 3. Feminization of higher veterinary education.
The effect of a preparation based on secondary bile acids on the regeneration of the liver parenchyma in the modeling of toxic hepatitis
Authors: Ponamarev V. S. , Lunegov A. M. 
Published: January 2022

Relevance. When using rodents as biological models using hepatotoxicants of different structure and mechanism, it was noted that tissue repair plays a decisive role in determining the final result of toxicity. Tissue regeneration is a complex process driven by multilevel cellular signaling involving a number of chemokines, cytokines, growth factors and nuclear receptors leading to the expression of promitogenic genes and cell division. Tissue repair also includes regeneration of the liver’s extracellular matrix and angiogenesis, processes required to completely restore the structure and function of the liver. Stimulating liver tissue through pharmacological correction is critical for recovery from toxic damage.Methods. The study was conducted on the basis of the St. Petersburg State University of Veterinary Medicine for 21 days. Two groups of white nonlinear rats, nine animals in each group, were used in the experiment. When modeling toxic hepatitis and further pharmacological correction promoting the regeneration of the liver parenchyma the drug “Hepaton” was used based on secondary bile acids (therapeutic dosage for rats – 0.5 mg/kg, duration of pharmacological correction – 21 days).Results. After 21 days, the experimental animals were euthanized according to the principles of bioethics, after which a histological examination of the liver was carried out. On histological sections of the liver of animals of the second experimental group the drug “Hepaton” reliably positively influenced the regenerative abilities of the liver parenchyma. Based on both experimental and data from the scientific literature, it can be concluded that drugs based on bile acids have an extremely wide range of applications in the future for pharmacological correction of various pathologies of the hepatobiliary system.
Comparative characteristics of feeding natural mineral supplements to lactating cows from different deposits
Authors: Mitsurina E. A. , Gamko L. N. 
Published: January 2022

Relevance. The article presents data on the effect of feeding lactating cows with different doses of natural mineral additives “Stimul” and smectite trepel as part of the feed mixture at the same concentration of metabolic energy in the diets, their effect on increasing milk yield, the amount of milk fat and protein in both the first and second experiments, their impact on increasing profitability and reducing the cost of exchange energy per 1 kg of milk.Methods. The effect of the inclusion of mineral additives “Stimul” and smectite trepel in the diet of lactating cows in 3.0% and 4.0% concentrations was studied, the composition of which includes about 40 mineral elements in an accessible form for the body, for the realization of the bioresource potential of the productivity of animals with a live weight of 400–450 kg in the conditions of the farm of ООО “Molochnoye”, Trubchevsky district of the Bryansk region. Before feeding, the mineral is subjected to high-temperature activation, grinding and separation into fractions. Crushing and dividing into fractions mineral additives from different deposits facilitate their use in feeding lactating cows.Results. The results of the research showed, that mineral supplements of different deposits in the diets of lactating cows have a stimulating effect on the mineral metabolism in the body of animals, and are consistent with the data of other authors. The analysis of the results of a comparative study of the productive qualities of cows for the experiment showed, that the inclusion of natural mineral supplements in the diet of lactating cows is cost-effective. The level of profitability when using the mineral additive smektitny trepel in the amount of 3.0% and 4.0% was higher by 5.3% and 18.6%then the mineral additive “Stimul”.
Productivity of soft winter wheat varieties of various ecological groups in the Middle Volga region
Authors: Sukhorukov A. A. , Sukhorukov A. F. 
Published: January 2022

Relevance. Creation and introduction of high-yield varieties of soft winter wheat into production is one of the important ways to increase the production of wheat grain and increase its export potential.Materials and methods. The research was conducted in 2017–2019. according to the methodology of the State Commission for variety testing of agricultural crops. Statistical data processing was performed by the method of one-factor analysis of variance according to B.A. Dospekhov (1985) in Excel. In 2017 55 varieties were evaluated, in 2018 – 98 varieties, in 2019 – 150 varieties of north caucasian, forest-steppe southern (Ukrainian), steppe southern (Ukrainian), Volga forest-steppe, north russian, central european, north european, north american ecological groups of soft winter wheat.Results. Phenological observations made it possible to establish ecogroups with the minimum duration of the spring vegetation renewal – earing period in the experiments – the north caucasian – 47 days and the maximum – the north russian – 57 days. Under favorable conditions of humidification, the yield of varieties of the north caucasian, southern steppe (Ukrainian), Volga forest-steppe, and north Russian ecological groups was: 7.06; 7.43; 7.24; and 7.08 t/ha, respectively. In the conditions of drought, the varieties of north caucasian, southern forest-steppe (Ukrainian), southern steppe (Ukrainian), and Volga forest-steppe were distinguished by yield: 3.03–3.27 t/ha. Sharply reduced the yield of varieties of the north russian ecogroup – 0.0–1.18 t/ha.
Leguminous crops in the Republic of Bashkortostan
Authors: Nurlygayanov R. B. , Islamgulov D. R. , Giniyatova F. F. , Zainagabdinov A. F. 
Published: January 2022

Relevance. Legumes are a source of cheap protein. The importance of the cultivation of leguminous crops at the planetary level in order to combat the starvation of a part of the world’s population was marked by the year 2016, declared the International year of leguminous crops. In the Republic of Bashkortostan the main leguminous crop is peas. In recent years other leguminous cropshave been growing in the region, such as vetch, soy, chickpeas, and forage beans, which play a significant role in the production of protein for food and feed purposes.Results. Due to the increase in the production of nitrogen mineral fertilizers in Russia, the area of leguminous crops as a source of biological nitrogenbegan to decrease, another problems are low productivity and complexity of cultivation technology. Two-phase harvesting of a mixture of winter vetch with winter rye increases the yield of winter vetch grain by 0.51 t/ha, the protein content – by 1.8% in comparison with direct harvesting. The highest height of the lower bean in soybean plants is formed when sowing with a row spacing width of 70 cm as a result of intraspecific competition. Processing chickpea seeds with the biological preparation Rizotorfin B increases grain yield by 0.27 t/ha with a production profitability of 151.6%.
Ecological adaptability parameters of the alfalfa varietal samples according to the trait “seed productivity” in the Rostov region
Authors: Ignatiev S. A. , Regidin A. A. , Kravchenko N. S. , Goryunov K. N. 
Published: January 2022

Relevance. Adaptive plant breeding is considered an effective and affordable tool that allows to develop varieties that are weakly responsive to the emerging unfavorable conditions.Methodology. The current study of the alfalfa samples was carried out on the experimental plots of the ARC “Donskoy”. The objects of research were the varieties of the ARIPGR (VIR) collection (11 samples from the USA, 16 samples from Canada, 2 samples from France, 1 sample from Peru).Results. Estimation of the alfalfa varietal samples according to some ecological adaptability parameters according to the trait “seed productivity” showed that the varietal samples from this collection respond differently to the environmental changes in their cultivation. The genotypes K-32783, K-42684, K-42685, K-48773, K-48774, K-48775, K-42694, K-45119, K-45715, K-47800, K-47801, K-47802, K-47803, K-47804, K-39978 and K-42712 had bi < 1 and hardly responded to the changes in growing conditions, and they had stable, although not very high, seed productivity. There have been identified the samples K-32783, K-42694, K-47801 and K-42712 that demonstrated their resistance to stress conditions. The samples K-50545 and K-50561 turned out to be genetically flexible, their “compensatory ability” better corresponded to the environmental factors. The genotypes K-43272, K-50545 and K-50561 were characterized with higher coefficient (σd 2) of the productivity stability in comparison with the standard variety.
Virtual screening of Osimertinib and Dacomitinib Analogues with potential activity on EGFR (T790M and l858R Mutations) for non-small cell lung cancer treatment
Authors: Luna Torres Leydis , Contreras Puentes Neyder , Avíz Amador Antistio 
Published: January 2022

Introduction: Tyrosine kinase inhibitors (TKIs) drugs act on epidermal growth factor (EGFR) receptors to treat Non-small cell lung cancer (NSCLC). However, mutations on EGFR receptors T790M and L858R allow just a global response rate (GRR) of 80% with Osimertinib, while Erlotinib and Gefitinib only 10%.
Objective: To identify promising molecules analogues to tyrosine kinase inhibitor (TKIs) drugs with the potential capacity to bind the native and mutated EGFR receptor (T790M and L858R) to avoid mutational resistance in NSCLC.
Methods: Virtual screening by molecular docking between analogues of Osimertinib (DB09330) and Dacomitinib (DB11963) drugs retrieved of DRUGBANK database and receptors of native EGFR and mutated on L585R and T790M obtained of Protein Data Bank was performed, using PyRx software. Finally, toxicological prediction was made using GUSAR.
Results: Analogues studied, DB03878, DB04739, DB07280 and DB06876 achieved significant affinity (-9,1 y -8,3 Kcal/mol) on mutated T790M EGFR compared with osimertinib (-7,6 Kcal/mol). Similarly, DB08091, DB08730, DB07220 and DB06920 achieved significant affinity (between 9.4 and -8.9 Kcal/mol) on L858R EGFR mutated compared with dacomitinib (-7.0 Kcal/mol). Overall, there were predominance of Van der Waals forces and links π-alkyl. Also, two analogues were safe with category IV according to predictions, DB08730 and DB03878.
Conclusions: Eight TKI analogues showed superior binding energy over EGFR compared to reference drugs. According to toxicological predictions only 2 analogues were selected as promising TKI-type safe candidates for the treatment of resistant NSCLC.
Medición de la calidad de vida de pacientes con artritis reumatoide atendidos en el Hospital Universitario del Caribe, Bolívar, Colombia
Authors: Rodríguez Cantillo Jonathan , López Crespo Juan , Polo Ibarra Javier , Moreno Grau Álvaro , Alvis Guzmán Nelson , Zakzuk Sierra Josefina 
Published: January 2022

Introducción: en varias poblaciones se ha evidenciado un deterioro de la calidad de vida y de la capacidad funcional en pacientes con artritis reumatoide. Estos aspectos son importantes para tener en cuenta en el manejo de la enfermedad, pues en algunos casos han sido complementarios en la toma de decisiones sobre los enfoques y conductas terapéuticas. Hasta ahora, en el departamento de Bolívar, Colombia, se desconoce el grado de afectación de la calidad de vida asociada a esta condición de salud.
Objetivo: describir la afectación de la calidad de vida del paciente diagnosticado con artritis reumatoide en el departamento de Bolívar y establecer relaciones con sus características sociodemográficas y de severidad de la enfermedad.
Métodos: se hizo uso de las escalas HAQ-DI y EQ-5D-3L, así como de la escala DAS28-VSG para la medición de la actividad clínica de la enfermedad.
Resultados: el 77,1% de los pacientes indicó afectación en su calidad de vida con predominio de afectación moderada, siendo más frecuente el dolor/malestar (57,1%), y menos común el cuidado personal (40%). La afectación de la calidad de vida se correlacionó con la actividad clínica de la enfermedad y el nivel de incapacidad funcional. La actividad clínica de la enfermedad fue el predictor más importante de la incapacidad funcional medida por HAQ-DI.
Conclusión: en esta muestra representativa de pacientes con artritis reumatoide del departamento de Bolívar, se presenta una importante afectación en la calidad de vida.
Etnocentryzm konsumencki wśród polskich konsumentów w dobie pandemii koronawirusa COVID-19
Authors: Szabuniewicz Joanna , Majkut Robert 
Published: January 2022

<p>Przedmiotem artykułu jest
etnocentryzm konsumencki. Zjawisko to w artykule zostało ogólnie
scharakteryzowane w ujęciu teoretycznym, w którym wyjaśniono, na czym ono
polega oraz jakie są jego czynniki zarówno o charakterze uniwersalnym, jak i
odnoszące się do postaw konsumentów w Polsce. W takiej perspektywie omówione
zostały wyniki badań empirycznych nad poziomem etnocentryzmu konsumenckiego w czasie
pandemii koronawirusa COVID-19. Wyniki badań wskazują, że pandemia koronawirusa
jest czynnikiem w nieznacznym stopniu wyzwalającym wzmożone postawy
etnocentryczne.<br></p>
Rancang Bangun Aplikasi Marketplace Untuk Selebgram Berbasis Web
Authors: Mulyani Asri , Pujianti Ranti Rahayu , Sukirno Sukirno 
Published: January 2022

Pemasaran merupaakan ujung tombak dari sebuaah bisnis, sebagaimana diketahui nama brand sudah memiliki nilai dimasyarakat selain itu sangat berpengaruhnya seorang influencer dalam mewarnai pola hidup masyarakat. Dengan demikian apabila dikombinasikan antara kebutuhan pengusaha untuk melakukan pemasaran dan influencer yang memiliki pengaruh di masyarakat maka dapat menjadi sebuah inovasi apabila dibuat sebuat platform yang yang menampung katalog jasa endorsment dari pada selebgram. Katalog jasa endorsment terpusat dibangun melalui sistem informasi berbasis web dimana pelanggan bisa melihat daftar selebgram beserta informasi detil mengenai akun dan melakukan transaksi didalamnya. Sistem informasi tersebut dibangun menggunakan metodologi Unifieed Softwaree Developmennt Proces (USDP) adalah tahapannya yaitu mendefinisikan model analisiss, model perancangaan, model devlopmnet, implementasii serta model pengujiaan. Proses pemodelaan menggunaakan Unifieed Modeling Languege. Hasil dari penelitian berupa sebuah marketplace yang bernama socialbuzzer yang dikelola oleh manajemen artis untuk menjadi perantara antara pengusaha dan selebgram.
KLASIFIKASI DAN JENIS TANAMAN PADA HALAMAN BANGUNAN SUCI DALAM RELIEF CANDI BOROBUDUR
Authors: Eka Puspitasari Dian Eka 
Published: January 2022

Jenis tanaman pada relief merupakan salah satu objek penelitian yang cukup menarik, karena tanaman digambarkan dengan sangat detail pada relief. Relief tanaman menjadi salah satu latar belakang dari konteks cerita dalam relief sehingga dapat menggambarkan konteks lingkungan dengan tepat. Perbedaan konteks lingkungan hutan, tepi laut, sungai, permukiman maupun kebun terlihat dengan jelas. Salah satu konteks lingkungan adalah konteks lingkungan halaman terutama halaman pada bangunan suci/candi. Bangunan suci/candi beberapa kali muncul dalam konteks cerita relief dimana beberapa penggambaran memiliki latar belakang tanaman. Jenis tanaman apa saja yang ada pada halaman bangunan suci/candi dalam konteks cerita relief serta fungsinya dalam lanskap menjadi topik dalam penelitian ini. Penelitian difokuskan pada relief Karmawibhangga, Lalitavistara, dan Jataka-Avadana yang berada di dinding utama lorong I. Dengan menggunakan metode selected observation dan fokus observation, identifikasi jenis tanaman menjadi lebih mudah. Hasil penelitian menemukan 20 jenis tanaman dengan 11 jenis tanaman yang berfungsi sebagai peneduh, 8 jenis tanaman yang berfungsi sebagai penghias, dan satu jenis tanaman yang berfungsi sebagai peneduh dan penghias pada konteks tanaman halaman bangunan suci/candi.
Kata Kunci : Jenis tanaman; bangunan candi; bangunan suci; halaman ; tanaman halaman
BIODIVERSITAS KAPANG PADA PROSES BIODETERIORASI BATUAN CANDI BOROBUDUR
Authors: Munawati Retna 
Published: January 2022

Penelitian ini bertujuan untuk mengetahui keanekaragaman kapang yang dapat menyebabkan biodeteriorasi pada batuan Candi Borobudur dan jenis kerusakan yang ditimbulkan. Penelitian ini merupakan penelitian deskriptif kualitatif. Metode yang digunakan pada penelitian ini adalah metode purposive sampling, dengan kriteria sampel : batuan candi yang menampakkan spora atau miselium kapang, serta menampakkan kerak berwarna putih atau putih kekuningan. Metode pengambilan sampel dengan metode swab dan metode kerik. Inokulasi kapang menggunakan metode streak plate pada media CDA. Hasil penelitian berupa data kualitatif meliputi karakterisasi makroskopis dan mikroskopis. Hasil karakterisasi kemudian diidentifikasi dengan metode profile matching menggunakan buku acuan identifikasi kapang. Berdasarkan hasil identifikasi, terdapat 5 genus kapang yang ditemukan pada batuan Candi Borobudur yaitu genus Paecilomyces (67,5%), Cladosporium (11,25%), Penicillium (11,25%), Aspergillus (8,75) dan Mucor (1,25%). Jenis biodeteriorasi yang terjadi pada batuan candi diantaranya adalah adanya perubahan warna pada permukaan batuan candi yang menampakkan kerak berwarna putih maupun putih kekuningan dan pembentukan biofilm.
Chronic skin diseases and pathology of gastrointestinal tract: Is there a connection?
Authors: Mikheenko P. V. , Akhmedov V. A. 
Published: January 2022

Currently,chronicdermatoseshavebecomewidespreadinthepopulation,whileitisoftennotpossibletoachievethedesiredeffectofthetherapy.Theanalysisofmodernliteraturedataindicatesa high prevalence of gastrointestinal diseases among patients with a dermatological profi On the one hand, a skin lesion can be a valuable differential diagnostic criterion for early diagnosis of digestive tract pathology. On the other hand, the common origin at the early stages of ontogenesis determines the development of a number of diseases with simultaneous damage to both the digestive organs and the skin. The presented review evaluates the relationship of skin pathology with the state of the digestive tract, and also considers the feasibility of including additional measures aimed at the diagnosis and treatment of diseases of the gastrointestinal tract in the management of patients with chronic dermatoses.
Frequency of detection of Helicobacter pylori and herpesvirus infection in patients with morphological changes in gastric mucosa
Authors: Afanasenkova T. E. , Dubskaya E. E. 
Published: January 2022

Aim. Based on the histological conclusion, to evaluate the frequency of detection of helicobacteriosis and herpesvirus infection in patients with morphological changes in the gastric mucosa.Materials and methods. Retrospectively, according to the logs of registration of endoscopic studies and registration of directions for histological studies for 2017–2021 of the endoscopic office of the polyclinic No. 2 in Smolensk city of Russia, the results of histological studies of biopsies of the gastric mucosa in 651 patients tested for H. pylori infection and herpesvirus infection were evaluated.Results. It is preferable to consider in the formation of inflammation the influence not of individual H. pylori bacteria, but the value of the entire mucosal microflora of the stomach and duodenum. The role of herpes viruses in the development of inflammatory and destructive pathology of the stomach and duodenum is noted. In patients infected with H. pylori and HVI in the SOH, there are structural changes in which destructive processes may have a deeper character, which will affect the timing of achieving remission.Conclusions. 1). In the description of the histological picture of the gastric mucosa, H. pylori was determined in 85.41 % of cases: with polyposis –97.05 %, oncopathology – 100 %, peptic ulcer – 94.50 %, chronic gastritis – 89.28 % of cases. 2). Herpes types 1, 2, 6, 8, EBV, cytomegalovirus from 220 biopsies were detected in 83.18 % of cases. EBV was most often present in the gastric mucosa from herpesvirus infection – 74.20 % of cases (with peptic ulcer in 78.00 %, with chronic gastritis in 84.71 %). 3). Simultaneously, herpesvirus infection and H. pylori were detected in 120 patients: with peptic ulcer – 68.00 %, with chronic gastritis – 75.29 % of cases.
Modern approaches in treatment of helicobacteriosis in patients with peptic ulcer
Authors: Levitan B. N. , Skvortsov V. V. , Samokhvalova P. D. 
Published: January 2022

Peptic ulcer is a chronic recurrent disease, accompanied by alternating periods of exacerbation and remission, its main feature is the formation of an ulcer in the wall of the stomach and (or) duodenum, penetrating – in this difference from superficial damage to the mucous membrane (erosions) – into the submucosal layer. The etiology is the appearance of Helicobacter pylori (H. pylori) falling into favorable conditions with weakened microfl and the presence of aggressive factors from the environment. In the pathogenesis of peptic ulcer disease, thinning of the gastrointestinal mucosa and violation of compensation mechanisms at the local level are of paramount importance. An important role in the diagnosis is given to a carefully collected anamnesis and complaints of the patient, supplemented by physical examinations, laboratory and instrumental examination methods. The treatment of patients is based on modern methods of treatment, where the latest drugs with proven effi and well-proven in clinical practice are used, consistent with the international recommendations of the Maastricht V / Florence Consensus, where anti-helicobacter therapy is mandatory for patients with peptic ulcer and chronic gastritis. Currently, treatment is still based on a combination of antimicrobial agents (amoxicillin, clarithromycin, metronidazole), and antisecretory agents (proton pump inhibitors). Standard triple therapy, which includes PPIs and two antibiotics (clarithromycin and amoxicillin/metronidazole) are widely used as a main-line regimen for the treatment of infection. In addition, the concomitant use of alternative medicine is important for the emergence of adaptive or synergistic effects against H. pylori infection.