bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of the Ohio Children's Opportunity Index
Authors: Fareed Naleef , Singh Priti , Jonnalagadda Pallavi , Swoboda Christine , Odden Colin , Doogan Nathan 
Published: July 2022

ObjectiveTo describe the development of an area-level measure of children's opportunity, the Ohio Children's Opportunity Index (OCOI).Data Sources/Study SettingSecondary data were collected from US census based-American Community Survey (ACS), US Environmental Protection Agency, US Housing and Urban Development, Ohio Vital Statistics, US Department of Agriculture-Economic Research Service, Ohio State University Center for Urban and Regional Analysis, Ohio Incident Based Reporting System, IPUMS National Historical Geographic Information System, and Ohio Department of Medicaid. Data were aggregated to census tracts across two time periods.Study DesignOCOI domains were selected based on existing literature, which included family stability, infant health, children's health, access, education, housing, environment, and criminal justice domains. The composite index was developed using an equal weighting approach. Validation analyses were conducted between OCOI and health and race-related outcomes, and a national index.Principal FindingsComposite OCOI scores ranged from 0–100 with an average value of 74.82 (SD, 17.00). Census tracts in the major metropolitan cities across Ohio represented 76% of the total census tracts in the least advantaged OCOI septile. OCOI served as a significant predictor of health and race-related outcomes. Specifically, the average life expectancy at birth of children born in the most advantaged septile was approximately 9 years more than those born in least advantaged septile. Increases in OCOI were associated with decreases in proportion of Black (48 points lower in the most advantaged vs. least advantaged septile), p &lt; 0.001) and Minority populations (54 points lower in most advantaged vs. least advantaged septile, p &lt; 0.001). We found R-squared values &gt; 0.50 between the OCOI and the national Child Opportunity Index scores. Temporally, OCOI decreased by 1% between the two study periods, explained mainly by decreases in the children health, accessibility and environmental domains.ConclusionAs the first opportunity index developed for children in Ohio, the OCOI is a valuable resource for policy reform, especially related to health disparities and health equity. Health care providers will be able to use it to obtain holistic views on their patients and implement interventions that can tackle barriers to childhood development using a more tailored approach.
Corticosteroids showed more efficacy in treating hospitalized patients with COVID-19 than standard care but the effect is minimal: A systematic review and meta-analysis
Authors: Liu Jixin , Dong Jing , Yu Yage , Yang Xinna , Shu Juan , Bao Hairong 
Published: July 2022

BackgroundDuring the ongoing coronavirus disease 2019 (COVID-19) pandemic, the use of corticosteroids for COVID-19 has ignited worldwide debate. Previous systematic reviews, including randomized controlled trials (RCTs) and retrospective observational studies, found that corticosteroids have beneficial effects in treating COVID-19.AimThis systematic review and meta-analysis only included RCTs to assess the effectiveness and safety of corticosteroids in hospitalized patients with COVID-19.MethodsComprehensive research strategies (PubMed, Embase, MEDLINE, and Coherence Library) were used to search for RCTs from December 2019 to January 2021.ResultsFive RCTs were included with 7,235 patients, of which 2,508 patients were receiving corticosteroid treatments (dexamethasone or methylprednisolone), and 4,727 received standard care. The primary outcome was mortality within 28 days. The use of corticosteroids decreased the 28-day mortality of patients with COVID-19, but the findings were not statistically significant (RR, 0.91; 95% CI, 0.78–1.06, p = 0.24). The secondary outcome was the duration of hospitalization; no differences were found between the corticosteroid and standard care groups. However, corticosteroids were associated with a higher hospital discharge rate than standard treatment, but the result was not statistically significant (RR, 1.36; 95% CI, 0.95–1.96, p = 0.09).ConclusionsThe results suggest that corticosteroids are comparable to standard care in terms of safety in treating COVID-19. Corticosteroids showed greater efficacy than standard care; however, the effect was minimal.
When Lack of Trust in the Government and in Scientists Reinforces Social Inequalities in Vaccination Against COVID-19
Authors: Bajos Nathalie , Spire Alexis , Silberzan Léna , Sireyjol Antoine , Jusot Florence , Meyer Laurence , Franck Jeanna-Eve , Warszawski Josiane ,   The EpiCov study group
Published: July 2022

ObjectiveTo assess whether lack of trust in the government and scientists reinforces social and racial inequalities in vaccination practices.DesignA follow-up of the EpiCov random population-based cohort survey.SettingIn July 2021, in France.ParticipantsEighty-thousand nine hundred and seventy-one participants aged 18 years and more.Main Outcome MeasuresAdjusted odds ratios of COVID-19 vaccination status (received at least one dose/ intends to get vaccinated/ does not know whether to get vaccinated/refuses vaccination) were assessed using multinomial regressions to test associations with social and trust factors and to study how these two factors interacted with each other.ResultsIn all, 72.2% were vaccinated at the time of the survey. The population of unvaccinated people was younger, less educated, had lower incomes, and more often belonged to racially minoritized groups, as compared to vaccinated people. Lack of trust in the government and scientists to curb the spread of the epidemic were the factors most associated with refusing to be vaccinated: OR = 8.86 (7.13 to 11.00) for the government and OR = 9.07 (7.71 to 10.07) for scientists, compared to vaccinated people. Lack of trust was more prevalent among the poorest which consequently reinforced social inequalities in vaccination. The poorest 10% who did not trust the government reached an OR of 16.2 (11.9 to 22.0) for refusing to be vaccinated compared to the richest 10% who did.ConclusionThere is a need to develop depoliticised outreach programmes targeted at the most socially disadvantaged groups, and to design vaccination strategies conceived with people from different social and racial backgrounds to enable them to make fully informed choices.
The diagnostic utility of IL-10, IL-17, and PCT in patients with sepsis infection
Authors: Zhang Wei , Wang Weiwei , Hou Weiwei , Jiang Chenfei , Hu Jingwen , Sun Li , Hu Liqing , Wu Jian , Shang Anquan 
Published: July 2022

ObjectiveThe purpose of this study is to determine the diagnostic value and net clinical benefit of interleukin-10 (IL-10), interleukin-17 (IL-17), procalcitonin (PCT), and combination tests in patients with sepsis, which will serve as a standard for sepsis early detection.Patients and methodsAn investigation of 84 sepsis patients and 81 patients with local inflammatory diseases admitted to the ICU of Tongji University Hospital in 2021. In addition to comparing inter-group variability, indicators relevant to sepsis diagnosis and therapy were screened.ResultsLASSO regression was used to examine PCT, WBC, CRP, IL-10, IFN-, IL-12, and IL-17. Multivariate logistic regression linked IL-10, IL-17, and PCT to sepsis risk. The AUC values of IL-10, IL-17, PCT, and the combination of the three tests were much higher than those of standard laboratory infection indicators. The combined AUC was greater than the sum of IL-10, IL-17, and PCT (P &lt; 0.05). A clinical decision curve analysis of IL-10, IL-17, PCT, and the three combined tests found that the three combined tests outperformed the individual tests in terms of total clinical benefit rate. To predict the risk of sepsis using IL-10, IL-17, and PCT had an AUC of 0.951, and the model's predicted probability was well matched. An examination of the nomogram model's clinical value demonstrated a considerable net therapeutic benefit between 3 and 87%.ConclusionThe IL-10, IL-17, and PCT tests all have a high diagnostic value for patients with sepsis, and the combination of the three tests outperforms the individual tests in terms of diagnostic performance, while the combined tests have a higher overall clinical benefit rate.
An update on the impact of SARS-CoV-2 pandemic public awareness on cancer patients' COVID-19 vaccine compliance: Outcomes and recommendations
Authors: Souan Lina , Sughayer Maher A. , Abu Alhowr Maha , Ammar Khawlah , Bader Sara Al 
Published: July 2022

Background:Aside from the pandemic's negative health effects, the world was confronted with public confusion since proper communication and favorable decisions became an ongoing challenge. As a result, the public's perceptions were influenced by what they knew, the many sources of COVID-19 information, and how they interpreted it. With cancer patients continuing to oppose COVID-19 vaccines, we sought to investigate the COVID-19 pandemic and vaccine sources of this information in adult cancer patients, which either helped or prevented them from taking the vaccine. We also assessed the relevance and impact of their oncologists' recommendations in encouraging them to take the vaccine.MethodsFrom June to October 2021, an online survey was conducted at King Hussein Cancer Center. A total of 441 adult cancer patients took part in the study. Patients who had granted their consent were requested to complete an online questionnaire, which was collected using the SurveyMonkey questionnaire online platform. Descriptive analysis was done for all variables. The association between categorical and continuous variables was assessed using the Pearson Chi-square and Fisher Exact.ResultsOur results showed that 75% of the patients registered for the COVID-19 vaccine, while 12% refused vaccination. The majority of participants acquired their information from news and television shows, whereas (138/441) got their information through World Health Organization websites. Because the SARS-CoV-2 vaccines were made in such a short period, 54.7 % assumed the vaccines were unsafe. Only 49% of the patients said their oncologists had informed them about the benefits of SARS-CoV-2 vaccines.ConclusionsWe found that SARS-CoV-2 vaccine hesitancy in cancer patients might be related to misinformation obtained from social media despite the availability of supportive scientific information on the vaccine's benefits from the physicians. To combat misleading and unreliable social media news, we recommend that physicians use telehealth technology to reach out to their patients in addition to their face-to-face consultation, which delivers comprehensive, clear, and high-quality digital services that guide and help patients to better understand the advantages of COVID-19 vaccines.
Economic Aspects in the Management of Diabetic Macular Edema in Italy
Authors: Calabrò Giovanna Elisa , Basile Michele , Varano Monica , Amore Filippo , Ricciardi Roberto , Bandello Francesco , Cicchetti Americo 
Published: July 2022

BackgroundDiabetic Macular Edema (DME) is the most common cause of vision loss in diabetic patients. Currently, the Vascular Endothelial Growth Factor inhibitors (anti-VEGFs) are used as the first line of DME treatment and corticosteroid implants are usually used as a second-line treatment. These implants are a safe and effective therapeutic option that can improve the quality of life of DME patients by reducing the intravitreal injections number. We determined the economic impact related to DME, also from the social perspective, and the consequences of the increased use of the dexamethasone implant.MethodsThe analysis compares two scenarios: the first based on the current rate of recourse to the therapeutic alternatives available in the Italian healthcare setting (as is) and the second based on the assumption of an increased recourse to dexamethasone implants (to be). The results are expressed both in terms of the resource absorption associated with the two scenarios and in terms of the cost differential yielded by their comparison.ResultsThe increased use of the dexamethasone implant allows considerable savings in terms of healthcare professionals' time, follow-up and productivity lost by patients/caregivers. These savings would reduce healthcare costs for the management of DME patients in Italy by €2,058,238 in 5 years.ConclusionsTo optimize the healthcare resources allocation, it is necessary to implement treatments that yield not only cost reductions but also a clinical benefit for patients. The dexamethasone implant use is an example of DME management that generates value for patients, health system and society.
Information disclosure, practical actions and dynamics of employees' health and safety issues in Chinese family businesses—Evidence based on Chinese a-share listed companies
Authors: Guo Yi , Li Aijun , Zhou Yi , Di Yuna 
Published: July 2022

IntroductionGlobal health emergency as COVID-19 has brought unprecedented concerns to the health and safety of employees, which is important yet long-neglected. This paper studies the mechanism and influencing factors of Chinese family enterprises performance in employees' health and safety from information disclosure, practical action and dynamic change. And based on theoretical framework and empirical model, this paper provides feasible regulatory policies on the behavior of family business.MethodsThis study construct a game theory framework and uses a sample of Chinese A-share listed companies. The database is provided by a third-party corporate social responsibility rating agency, SynTao Green Finance. We use empirical models to test the hypothesis from the theoretical model of game theory.ResultsIn practice, family businesses are less likely to fulfill the health and safety responsibilities of employees compared to non-family businesses. Family businesses are likely to be more motivated than other businesses to send signals that they are performing their responsibilities well. From the view of operation term, family businesses will be gradually inclined to better fulfill the health and safety responsibilities of their employees, while this process will show a “U” shape change over operation time.ConclusionsAs there is inconsistency between the information disclosure and actual practice of family enterprises when it comes to the issue of employee health and safety, more related regulatory policies and stakeholder monitoring are needed. Although the performance of family enterprises in this regard will be better in the long run, it is still necessary to improve employees' legal and rights awareness and enhance the effectiveness of supervision over external stakeholders.
Epidemiology of children's swimming competence and water safety
Authors: Santibañez-Gutierrez Asier , Fernández-Landa Julen , Calleja-González Julio , Todorović Nikola , Ranisavljev Marijana , Štajer Valdemar , Anđelić Bogdan , Zenić Nataša , Bianco Antonino , Drid Patrik 
Published: July 2022

IntroductionThe main purpose of this study was to investigate children's swimming competence in primary schools of districts in Vojvodina, Serbia.MethodsIncluded subjects were primary school students from first to eighth grade (N = 2,778; male = 1,454, female = 1,324; age = 10.73 ± 2.1 years). We used Swimming Competence Questionnaire to acquire and analyze their swimming experience, non-fatal aquatic events, and demographics. For the statistical analysis, logistic regression and hierarchical multiple regression were used to evaluate if the factors and SC and NFAE were associated. The analyses were carried out by using SPSS® software version 24.0 (SPSS, Inc., Chicago, Illinois, USA).ResultsFamilies with more income and education generally have children with more swimming competence, experience, knowledge, and skills related to water safety. First step in analysis revealed that gender (β = 0.05, p &lt; 0.01), education level (β = 0.06, p &lt; 0.01) age (β = 0.171, p &lt; 0.01), and family income (β = 0.04, p &lt; 0.01) were significant swimming competence (SC) predictors (R2 = 0.04). Age (OR = 1.15, p &lt; 0.01) was the only significant predictor in Step 1 predicting non-fatal aquatic events (NFAE). In Step 2, variables associated with SC were swimming location (ΔR2 = 0.06, p &lt; 0.01), swimming experience (ΔR2 = 0.16, p &lt; 0.01), swimming accessibility (ΔR2 = 0.05, p &lt; 0.01), and learning experience (ΔR2 = 0.03, p &lt; 0.01) (total R2 = 0.26 to 0.47, p &lt; 0.01). Only a minority of participants reported that they could not swim further than 5 meters using general stroke (37.15%).ConclusionNational education trainers programs must be prioritized with the primary strategy of transferring knowledge to swimming and water safety. Families with lower income must be included without exceptions. This is perhaps a key factor in preventing NFAE, increasing SC, and increasing water safety.
A protocol to evaluate the impact of embedding Public and Patient Involvement in a structured PhD program for stroke care
Authors: Horgan Frances , Lennon Olive , Hickey Anne , Sorensen Jan , Kroll Thilo , McCartan Deirdre , Hall Patricia , O'Callaghan Geraldine , Fitzgerald Clare , Hickey Julianne , Fahy Martin , Osborne Philip , Scullion Mary , Ní Bhroin Clíodhna , Williams David J. ,   The iPASTAR Collaborative Doctoral Award Programme Team
Published: July 2022

BackgroundEmbedding Public and Patient Involvement (PPI) in postgraduate research has been recognized as an important component of post-graduate training, providing research scholars with an awareness and a skillset in an area which prepares them for future roles as healthcare researchers. Improving Pathways for Acute STroke And Rehabilitation (iPASTAR) is a structured PhD training program [Collaborative Doctoral Award (CDA)] which aims to design a person-centered stroke pathway throughout the trajectory of stroke care, to optimize post-stroke health and wellbeing. PPI is embedded at all stages.PurposeThe iPASTAR research programme was strongly informed by a round-table PPI consultation process with individuals who experienced stroke and who provided broad representation across ages, gender, geographical locations (urban and rural) and the PhD themed areas of acute care, early supported discharge and lifestyle-based interventions after stroke. Four PhD scholars taking part in the CDA-iPASTAR now work collaboratively with four stroke champions, supported by a wider PPI advisory panel.MethodsThis study will evaluate the process and impact of embedding PPI during a PhD program. We will conduct a longitudinal mixed-methods evaluation, conducting focus groups at 24, 36, and 48 months to explore the experiences of the key stakeholders involved. The participants will include PhD scholars, PPI partners (PPI Advisory Group and PPI Champions), PhD supervisors and a PPI manager. An independent researcher will conduct the evaluation. We will include focus groups, individual interviews and participant reflections. Qualitative data will be analyzed using thematic and content analysis, quantitative data will be analyzed using descriptive statistics.DiscussionPPI and patient voice initiatives bring together researchers, family, and people with health care issues into meaningful dialogue and allow the development of a patient-voice learning network. Embedding PPI training within a PhD program can build meaningful capacity in PPI partnerships in stroke research.
Understanding the sexual and reproductive health needs of immigrant adolescents in Canada: A qualitative study
Authors: Meherali Salima , Louie-Poon Samantha , Idrees Sobia , Kauser Samar , Scott Shannon , Salami Bukola , Valliantos Helen , Meherali Kainat Moez , Patel Krishan , Suthar Puja , Akbarzada Zohra , Marcus Ivan , Khangura Manjot , Mangat Abneet 
Published: July 2022

BackgroundLiterature suggests that immigrant adolescents receive limited sexual and reproductive health (SRH) education and rarely utilize SRH services in Canada. This study sought to explore the SRH information needs of immigrant adolescents in the province of Alberta.MethodsA qualitative descriptive methodology was undertaken to conduct 21 individual interviews with immigrant adolescents in Alberta.ResultsA total of four themes emerged from the interviews: (1) Barriers to SRH; (2) needs of adolescents regarding SRH; (3) sources of knowledge; and (4) strategies to improve SRH. Our findings document the conflicting needs and preferences between adolescents and their parents regarding access to SRH resources and services.DiscussionAdolescents often felt unprepared to deal with their SRH issues due to socio-cultural barriers and conflicts with their parents' conservative attitude toward SRH concerns. Structural barriers to accessing SRH resources and services were also reported, including the location and cost of services. As a result, the majority of adolescents relied on digital methods to receive SRH information.ConclusionThis study highlights that future research and SRH service provider efforts need to remain cognizant of the positionality of immigrant adolescents and explore innovative ways to deliver SRH resources and services that meet their unique needs.
Physicochemical, rheological and structural properties of flours from six quinoa cultivars grown in Colombia
Authors: García-Parra Miguel , Polo-Muñoz María Paula , Nieto Calvache Jhon Edinson , Agudelo-Laverde Lina Marcela , Roa-Acosta Diego Fernando 
Published: July 2022

BackgroundInclusion of quinoa in the diet of consumers has generated a challenge for quinoa producers and food processors, which involves the study of new cultivars and the functional properties of their flours.MethodsSix quinoa cultivars (Titicaca, Blanca real, Soracá, Pasankalla, Puno and Nariño) were analyzed for their proximate composition using the methodologies proposed by the Association of Official Analytical Collaboration, AOAC. A rheological analysis was carried out with flours from each cultivar. A sequential test including a flow test, a pasting test and another flow test was programmed to evaluate the flow behavior before and after a heating process. In addition, the structural properties of the cultivar flours were evaluated by Fourier Transform Infrared spectroscopy (FTIR).ResultsIt was found that the Pasankalla, Titicaca and Soracá cultivars had a higher (p &lt; 0.05) protein content, while the Puno, Pansakalla and Blanca real cultivars stood out for their higher (p &lt; 0.05) lipid content. On the other hand, it was found that before heating, all quinoa flour dispersions had a dilatant flow (n &gt; 1), but after heating, all of them showed a decrease of index values, where the flours of the Titicaca and Pasankalla cultivars were more affected with a tendency toward a Newtonian flow (n ≈ 1). The pasting test showed that the viscosity varied according to the cultivar tested. It is noteworthy that both Titicaca and Soracá presented a high peak viscosity (0.16 ± 0.01 and 0.13 ± 0.02 Pa·s respectively) and different setback values on cooling (0.100 ± 0.028 and 0.01 ± 0.01 Pa·s respectively). Spectroscopic analysis showed a direct relationship between the intensity of the peaks and the nutritional content of the flours. In addition, secondary protein structures such as β-sheet, β-Turn, α-Helix and Random Coil were identified after deconvolution of the spectra. The differences in the protein structures of each cultivar could allow their identification by this methodology.ConclusionIt can be concluded that quinoa flours from the six cultivars could be used for the formulation of different food products, such as beverages, baked goods, snacks, pasta and others, acting as nutritional improvers and modifiers of rheological, textural and functional properties.