bluuebunny/crossref_metadata_2025_split huggingface dataset:
13C-methacetin breath test predicts survival in patients with hepatocellular carcinoma undergoing transarterial chemoembolization
Authors: Gairing Simon Johannes , Kuchen Robert , Müller Lukas , Cankaya Alper , Weerts Jan , Kapucu Akin , Sachse Simon , Zimpel Carolin , Stoehr Fabian , Pitton Michael B. , Mittler Jens , Straub Beate Katharina , Marquardt Jens Uwe , Schattenberg Jörn M. , Labenz Christian , Kloeckner Roman , Weinmann Arndt , Galle Peter Robert , Wörns Marcus-Alexander , Foerster Friedrich 
Published: September 2022

Abstract

Introduction:
The 13C-methacetin breath test (13C-MBT) is a dynamic method for assessing liver function. This proof-of-concept study aimed to investigate the association between 13C-MBT values and outcome in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE).

Methods:
A total of 30 HCC patients were prospectively recruited. Of these, 25 were included in the baseline, 20 in longitudinal analysis. 13C-MBTs were performed before the first and second TACE. Patients were followed for at least one year.

Results:
At baseline, median 13C-MBT value was 261 µg/kg/h (interquartile range (IQR) 159 - 387). 13C-MBT, albumin-bilirubin (ALBI), Child-Pugh and Model for End Stage Liver Disease (MELD) scores were associated with overall survival (OS) in extended univariable Cox regression (13C-MBT: standardized hazard ratio (sHR) 0.297, 95% confidence interval (CI) 0.111 - 0.796; ALBI score: sHR 4.051, 95% CI 1.813 - 9.052; Child-Pugh score: sHR 2.616, 95% CI 1.450 - 4.719; MELD: sHR 2.781, 95% CI 1.356 – 5.703). Using a cut-off of 140 µg/kg/h at baseline, 13C-MBT was associated with prognosis (median OS 28.5 months (95% CI 0.0 – 57.1) vs 3.5 months (95% CI 0.0 – 8.1), Log-Rank p < 0.001). Regarding prediction of 90-day mortality after the second 13C-MBT, the relative change in 13C-MBT values yielded an area under the ROC curve of 1.000 (p = 0.007).

Conclusions:
Baseline and longitudinal 13C-MBT values predict survival HCC patients undergoing TACE. The relative change in 13C-MBT value predicts short-term mortality and may assist in identifying patients who will not benefit from further TACE treatment.
Reevaluation of gastric cancer screening by Levin’s equation
Authors: Ishii Naoki , Shiratori Yasutoshi , Yano Takahiko , Konai Mimoe , Arai Yuki , Hamada Jun , Maekawa Hisato , Omata Fumio 
Published: September 2022

ABSTRACT

INTRODUCTION:
This study aimed to reevaluate the effectiveness of fluoroscopy and endoscopy in reducing gastric cancer mortality at the population level.

METHODS:
Crude and age-adjusted mortality rates of gastric cancer and the introduction rates of gastric cancer screening were extracted from the Cancer Registry and Statistics database. The population-attributable risk (PAR) percent (PAR%) of no screening for gastric cancer mortality was calculated using Levin’s equation. The PAR of each mortality rate in the no screening group was estimated as follows: mortality×PAR%. The Jonckheere-Terpstra test for trends and linear regression were performed to compare PAR of gastric cancer mortality rates among the decades.

RESULTS:
The PAR of crude and age-adjusted mortality rates in the no screening group significantly decreased in the total population (P for trend <0.001), as well as individually in the male (P for trend <0.001) and female (P for trend <0.001) populations. The PAR of crude mortality rate in the female population significantly decreased in 2000–2009 and 2010–2019, compared with that in 1980–1989. There was no significant difference in the PAR of crude mortality rate in the male population among the decades. The PAR of age-adjusted mortality rate significantly decreased in 2000–2009 and 2010–2019, compared with that in 1980–1989, in the male and female populations.

DISCUSSION:
PAR% and PAR of no screening for gastric cancer mortality could be estimated using Levin’s equation and the effectiveness of the present gastric cancer screenings with fluoroscopy and endoscopy has been decreasing, especially in the female population.
Analisis Pengaruh Produk Domestik Bruto, ICT Development Index Dan Good Governance Terhadap Indeks Pembangunan Manusia Anggota ASEAN Dan SAARC Kategori Lower-Upper Medium
Authors: Kristiawan Albertus Surya 
Published: September 2022

Pencapaian pembangunan ekonomi dapat dilihat pada keberhasilan pembangunan manusia. UNDP (2008) membuat indikator Indeks Pembangunan Manusia untuk mengukur perkembangan pembangunan manusia di suatu negara. Indeks Pembangunan Manusia di Negara ASEAN dan SAARC perlu dianalisis sebab masih termasuk kategori lower-upper medium. Penelitian ini bertujuan untuk menganalisis pengaruh Produk Domestik Bruto, ICT Dvelopment Index dan variabel Worldwide Governance Indicators terhadap Indeks Pembangunan Manusia.Hasil penelitian menunjukkan variabel produk domestik bruto, ICT development Index, dan political stability and absence of violence or terrorism memiliki hubungan yang positif dan signifikan, sedangkan control of corruption memiliki hubungan yang negatif dan signifikan terhadap indeks pembangunan manusia di negara ASEAN dan SAARC kategori lower-upper medium. variabel regulatory quality memiliki hubungan yang berbeda antara kedua organisasi regional. Pada ASEAN kategori lower-upper medium memeiliki hubungan yang positif dan signifikan sedangkan SAARC kategori lower-upper medium memiliki hubungan yang negatif dan signifikan.
ANALISIS PROFITABILITAS PADA INDUSTRI TEKSTIL DAN PRODUK TEKSTIL DI INDONESIA
Authors: Riyanto Eko 
Published: September 2022

This study aims to analyze profitability in the relationship between structure and performance of the textile and textile product industry in Indonesia with an annual 2011-2014. The type of data used is secondary data obtained from the Badan Pusat Statistik (BPS) of Indonesia. This study employs panel data regression with Fixed Effect Model (FEM). This research uses panel data to see effect of concentration ratio (CR4), internal efficiency (XEF), output value growth (Growth), and labor productivity (Prod) on profitability (PCM).The results of this research shows that the structure of textile and textile product industry in Indonesia is high-moderate oligopoly, with an average value of CR4 is 60.93 percent. The results of the regression shows internal efficiency (XEF) and labor productivity (Prod) have a positive significant effect on the profitability (PCM). While the concentration ratio (CR4) and output growth (Growth) does not have a significant effect on the profitability (PCM).
Analisa Perdagangan Bilateral Indonesia dengan Pendekatan Marshall Lerner Condition dan Fenomena J Curve
Authors: Wijaya Erric 
Published: September 2022

Penelitian ini membahas mengenai analisa perdagangan bilateral Indonesia dengan menggunakan fenomena J curve dan Marshall Lerner Condition. Sampel penelitian ini menggunakan tiga negara mitra dagang terbesar Indonesia yaitu Tiongkok, Jepang, dan Singapura. Periode penelitian dari tahun 2010 kuartal 1 sampai dengan 2017 kuartal 4. Alat analisis menggunakan regresi linear berganda dengan menggunakan pendekatan kointegrasi dan Error Correction Model (ECM). Hasil penelitian menunjukkan bahwa tidak terjadi fenomena J curve dan Marshall Lerner Condition untuk perdagangan bilateral antara Indonesia dengan Tiongkok dan Indonesia dengan Jepang. Sedangkan perdagangan bilateral antara Indonesia dan Singapura terjadi fenomena J curve dan Marshall Lerner Condition. Masing-masing variabel penelitian saling terkointegrasi pada jangka panjang dan juga pada jangka pendek melalui Error Correction Model (ECM). Pada jangka pendek perubahan nilai tukar tidak mempengaruhi perdagangan bilateral Indonesia dengan Jepang dan Singapura., tetapi berpengaruh pada perdagangan bilateral Indonesia dengan Tiongkok. Pada jangka panjang, perubahan nilai tukar berpengaruh pada perdagangan bilateral Indonesia dengan Tiongkok dan Singapura.
The Effect of Accounting Understanding and Tax Provisions on Calculating, Depositing, and Reporting of Tax at Pt. Xyz - A Case Study on a Startup
Authors: Panduwinata Vina , Sidharta Juaniva , Simanjuntak Ramot 
Published: September 2022

Technological developments gave a lot of influence on human life in general, from daily activities until there are several digital-based business models, known as startups. As of 2018, according to MIKTI (Indonesian: Masyarakat Industri Kreatif Teknologi Informasi, or Information Technology Creative Industry Society) database, there were 992 startups in Indonesia. Startup company tax is an obligation that must be paid on income received or transactions related to withholding PPh (Indonesian: Pajak Penghasilan, or Income Tax) made by startup companies and requires special tax treatment in order to develop their business. The factor of understanding tax accounting provides a significant contribution to the compliance of corporate taxpayers in fulfilling income tax obligations. The research in this journal aims to gain knowledge of the extent of understanding of accounting and tax provisions in depositing and reporting taxation at one of the startups in Greater Jakarta.
Clinical evaluation of the OC-Sensor Pledia calprotectin assay
Authors: Butenas Juozas , Ayling Ruth M. 
Published: September 2022

Abstract

Objectives
Faecal calprotectin (f-Cal) and faecal haemoglobin (f-Hb) are important tests for evaluation of gastrointestinal disease. Samples for measurement of f-Hb are taken by the patient directly into a specimen collection device containing stabilising buffer, which can be placed directly onto the analyser in the laboratory. Samples for f-Cal are usually sent in screw top pots and often require time-consuming extraction procedures prior to analysis. OC-FCa calprotectin is a new assay which uses the same specimen collection device and analyser as our current f-Hb assay. Analytical evaluation has already shown it to perform well but to have a positive bias. This study was a clinical evaluation to investigate the diagnostic test performance and cut-off suitable for its use in the diagnosis of IBD.

Methods
OC-FCa calprotectin was measured in a convenience sample of 603 patients in whom f-Hb had been requested and was found to be ≥10 μg/g. Clinical outcomes were obtained from notes, radiological reports and endoscopy and histology reports.

Results
A total of 425 patients completed clinical investigations; IBD was diagnosed in 49 and other colorectal pathology in 161. Median f-Cal in patients with IBD was 1,660 μg/g, significantly different (p<0.01) from those with other colorectal pathology (192 μg/g) or normal findings (157 μg/g). ROC curve analysis showed AUC of 0.898 with sensitivity of 91.8% and specificity of 79.3% at a cut-off of 600 μg/g.

Conclusions
The new OC-FCa calprotectin assay performed well for the diagnosis of IBD using a cut-off of 600 μg/g.
A case of placental multiple giant chorangioma leading to neonatal death from fetal hydrops
Authors: Shiraga Aoi , Ohsuga Takuma , Kawasaki Kaoru , Mogami Haruta , Minamiguchi Sachiko , Mandai Masaki 
Published: September 2022

Abstract

Objectives
Although placental chorangiomas are often asymptomatic, larger tumors (>4–5 cm) can cause various perinatal complications, including polyhydramnios, preterm birth, fetal anemia, fetal hydrops, and intrauterine fetal death. Symptomatic placental chorangiomas are often diagnosed prenatally on ultrasonography as a mass on the fetal side of the placenta.

Case presentation
A 37-year-old pregnant woman underwent emergency cesarean delivery at 34 weeks’ gestation due to rapidly progressive fetal hydrops leading to fetal dysfunction, resulting in neonatal death. Placental pathology indicated multiple placental giant chorangiomas that occupied 40% of the placenta. Because of the disk shape of the placenta, prenatal diagnosis by ultrasonography was difficult.

Conclusions
Some placental chorangiomas are difficult to diagnose and lead to fetal hydrops and poor prognosis, even if ultrasonography does not show an obvious mass in the placenta.
Teaching the science of uncertainty
Authors: Moulder Glenn , Harris Emily , Santhosh Lekshmi 
Published: September 2022

Abstract
As we increasingly acknowledge the ubiquitous nature of uncertainty in clinical practice (Meyer AN, Giardina TD, Khawaja L, Singh H. Patient and clinician experiences of uncertainty in the diagnostic process: current understanding and future directions. Patient Educ Counsel 2021;104:2606–15; Han PK, Klein WM, Arora NK. Varieties of uncertainty in health care: a conceptual taxonomy. Med Decis Making 2011;31:828–38) and strive to better define this entity (Lee C, Hall K, Anakin M, Pinnock R. Towards a new understanding of uncertainty in medical education. J Eval Clin Pract 2020; Bhise V, Rajan SS, Sittig DF, Morgan RO, Chaudhary P, Singh H. Defining and measuring diagnostic uncertainty in medicine: a systematic review. J Gen Intern Med 2018;33:103–15), as educators we should also design, implement, and evaluate curricula addressing clinical uncertainty. Although frequently encountered, uncertainty is often implicitly referred to rather than explicitly discussed (Gärtner J, Berberat PO, Kadmon M, Harendza S. Implicit expression of uncertainty - suggestion of an empirically derived framework. BMC Med Educ 2020;20:83). Increasing explicit discussion of – and comfort with -uncertainty has the potential to improve diagnostic reasoning and accuracy and improve patient care (Dunlop M, Schwartzstein RM. Reducing diagnostic error in the intensive care unit. Engaging. Uncertainty when teaching clinical reasoning. Scholar;1:364–71). Discussion of both diagnostic and prognostic uncertainty with patients is central to shared decision-making in many contexts as well, (Simpkin AL, Armstrong KA. Communicating uncertainty: a narrative review and framework for future research. J Gen Intern Med 2019;34:2586–91) from the outpatient setting to the inpatient setting, and from undergraduate medical education (UME) trainees to graduate medical education (GME) trainees. In this article, we will explore the current status of how the science of uncertainty is taught from the UME curriculum to the GME curriculum, and describe strategies how uncertainty can be explicitly discussed for all levels of trainees.
Nonconvergence toward the standard: the maintenance of a distinctive use of rhotics among the Santomean diaspora in Portugal
Authors: Bouchard Marie-Eve , Desmeules-Trudel Félix 
Published: September 2022

AbstractThe variable use of rhotics is a salient linguistic feature in the variety of Portuguese spoken on São Tomé Island. In this study, we employ ethnographic and variationist sociolinguistic methods to report on the use of rhotics by 40 Santomeans living in Portugal. The objective is to determine whether Santomeans who are in closer proximity with European Portuguese, which is the variety perceived as standard and more prestigious in Portugal, tend to use rhotics in a more standard way or if they maintain the distinctive use of rhotics from their island. The results indicate that Santomeans do not converge toward a more European standard use of rhotics. We argue that the distinctive use of rhotics is available for identity-driven use to express a connection to São Tomé and Príncipe.
Target location service system in microgrid operation based on internet of things
Authors: Zhang Jiajie 
Published: September 2022

Abstract
With the gradual reduction of conventional energy sources, the problem of environmental pollution is becoming more and more serious. Environmentally friendly, efficient and flexible power generation models are widely favored, and microgrids emerge as the times require. Microgrid is a medium and low voltage network including power distribution, storage devices, loads and other equipment. It can operate in grid-connected mode or as a stand-alone system in an island environment, continuing to supply power to users even when the large grid is disrupted. Compared with traditional power grids, microgrids have small capacity and changeable operation modes, making it difficult to locate distribution areas and short-circuit currents. At the same time, it is difficult to trace the faults during operation. So far, microgrids have had a lot of technical issues in operation that need to be resolved quickly. In recent years, IoT technology has developed rapidly. The Internet of Things is a comprehensive network that integrates location services, monitoring services, information identification and monitoring services through information exchange and communication technologies, such as video recognition technology, positioning technology, and wireless sensor technology. In order to monitor the operation mode of the microgrid in real time, find the source of the fault and locate the operation target, based on the Internet of Things technology, this paper installs wireless sensors in the line segment to monitor the line and other applications. This paper uses wireless sensor networks to record positioning variables, processes and data analysis to achieve the accuracy of microgrid operation target positioning. In addition, in order to improve the positioning accuracy of wireless sensor monitoring network and solve the problem of energy limitation, DV-Hop algorithm EB-IDMF algorithm and R-A algorithm are also introduced. Finally, the feasibility of the system is verified through experiments and tests. With the blessing of the positioning algorithm, the positioning accuracy is improved by 4.9%, which has great practical value for the target positioning of microgrid operation.
User-side precision marketing model of integrated energy service system
Authors: Yao Wei , Han Wei , Zheng Yong , Gao Songyao , Li Ran 
Published: September 2022

Abstract
Since entering the new era, the utilization and protection of energy has gradually become a world-class problem, and the establishment of a comprehensive energy service system is one of the effective solutions to today’s energy problems. The establishment of the comprehensive energy service system successfully integrates the fragmented and single energy structure and realizes the multi-energy complementarity between energy sources. However, the current comprehensive energy service is still limited to the integration of several common energy sources, and the system cannot realize dynamic dispatch between energy sources. User-side precision marketing can predict various energy demands. Therefore, establishing a user-side precision marketing model can strengthen the energy efficiency management of the energy system and realize the optimization and upgrading of the comprehensive energy service system. Based on this, we propose a user-side precision marketing model. It can effectively act on the comprehensive service system, and propose effective solutions for the forecast and dispatch of energy demand. At the same time, the article also aims to improve the utilization efficiency of multiple energy sources in comprehensive energy services, reduce multiple costs in energy dispatch, improve economic and environmental benefits, and promote energy conservation and emission reduction. Experiments show that the precise marketing model based on the user side can effectively increase the energy supply speed by 50.1%, reduce the supply cost by 32%, and improve the energy supply efficiency by 33%. This fully shows that the comprehensive energy supply and precision marketing model based on the user side can get rid of the previous single energy supply situation and improve energy utilization efficiency.
Halimeda gracilis (Kadarpassi chooranam) Phytochemical analysis and biological significance – a novel Siddha drug
Authors: J.V. Sabari Anandh , K. Manimekalai , A. Rajendra Kumar , S. Bragadeeswaran 
Published: September 2022

Abstract

Objectives
To evaluate biological activity and the phytochemical analysis of kadarpassi chooranam. Seaweeds are the marine macro algae, species belonging to Protista kingdom that has no true system, internal vascular systems, seeds and flowers. It has a lot of biological activity and has been proven to have a lot of medicinal benefits. Since time immemorial, their usage in traditional medicine has been recognized.

Methods

Halimeda gracilis has been standardized as per siddha pharmacopoeia standard protocol guidelines and prepared kadarpassi Chooranam curtained for Phytochemical analysis (qualitative and quantitative) and carried out various pharmacological activity.

Results
The antioxidant, anti-inflammatory, and anti-cancer actions of kadarpassi Chooranam have been associated to alkaloids, phenols, flavonoids, cardiac glycosides, saponins, tannins, and diterpenes.

Conclusions
The Siddha medicine, kadarpassi chooranam has various phytochemical bioactive compounds, and because of its pharmacological activity can be a potential drug candidate for human use.
Facts and doubts on the beginning of human life – scientific, legal, philosophical and religious controversies
Authors: Kurjak Asim , Stanojević Milan , Barišić Pavo , Ferhatović Amila , Gajović Srećko , Hrabar Dubravka 
Published: September 2022

Abstract
It is very complicated to give correct answer to the question “How to define human life?” Nowadays dilemmas consider the respect of human life from the birth to death involve not just biology but also other sciences like philosophy, theology, sociology, psychology, law and politics. These sciences evaluate the topic from different points of view. Integration of all of these perspectives could result with a proper definition. The principal purpose of this paper is to try to determine when a human individual begins. If this proves to be too difficult, we might have to settle for a specific stage in the reproductive process before which it would be impossible to say with any plausibility that a human individual exists. It is necessary to return the moral dimension of observation to the science of life. The point is to reconcile the universal ethical principles concerning the absolute value of life with the everyday challenges and dilemmas. It is our deepest conviction that life has an absolute value and that there always remains something indestructible and substantial in life, which may neither be evaluated by anything final, nor completely reduced to the material biological equivalent and the genetic substratum.