bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of soil bulk density and water content on penetration resistance
Authors: Lardy Jarrett M. , DeSutter Thomas M. , Daigh Aaron L. M. , Meehan Miranda A. , Staricka James A. 
Published: November 2022

AbstractInfrastructure installation (e.g., pipelines) disturbs soils, often resulting in increased soil compaction (bulk density [Bd] and penetration resistance [PR]). The relationship of PR to Bd, gravimetric water content (Θg), and a suite of other properties were determined on seven topsoils to provide a model and database for reclamation specialists to use when assessing disturbed soils. Penetration resistance had a strong linear association with Bd, but higher Θg reduced the range of PR as Bd increased. Step‐wise regression identified Bd, Θg, texture, clay speciation, and organic matter as significant factors to predict PR. The model predicts PR from <1 to 8 MPa and closely match measured values. Soil Bd and Θg contributed to 84% of the model's explained variation in predicting PR. This study provides a tool for reclamation specialists that aids in understanding the risks associated with disturbances and highlights the importance of keeping Θg low during installation of pipelines.
Acute appendicitis with appendix duplicity in Eritrea: A case report
Authors: Yassin Rami , Mohmed Mhmoud , Fekadu Tekeste 
Published: November 2022

AbstractDuplicity of the appendices is very rare. A 32‐year‐old man presented with type B2 duplicity of the appendix and acute appendicitis. An appendectomy was done for both. Intraoperative incidental finding is the only chance to avoid missing appendix duplicity and appendicectomy should be done for both.
Burden of COVID‐19 on health and wellbeing, education, and economy of Bangladesh
Authors: Rahman Azizur , Abdulla Faruq , Karimuzzaman Md , Hossain Md Moyazzem 
Published: November 2022

AbstractThe long‐term impact of this pandemic will continue in almost all sectors of a country such as health, economic situations, education, mental health, and violence. Therefore, the authors intended to discuss the prolonged effect of COVID‐19 on the health along with wellbeing, education, and economy of Bangladesh through a mixed approach. To assess the possible scenario in health sector of Bangladesh, we conducted a short survey through online with a structured questionnaire. The impact of the pandemic is highlighted by graphical presentations and discussed the issues in light of the existing literature. It is realized that health care services and resources are always essential for predominant health conditions and fatal diseases patients. Mental health has also been impacted a lot during this pandemic. Moreover, students of only those schools located in urban areas are attended some online classes but due to the internet interruption and scarcity of devices students from rural areas cannot attend the classes and it will widen the gap between pupils from urban areas and those who live in remote rural areas. Additionally, many students terminate school. The country's youth unemployment is projected to intensify as a result of the economic effects, which would promote antisocial behavior and cause social discontent among young people. Also, the flow of remittances greatly declined in the last couple of months and a many people were jobless abroad, and the majority of them were sent back home. The demographic dividend's intended results are expected to be negatively impacted by COVID‐19's overall effect as well as sustainable development goals (SDGs) in Bangladesh. Therefore, many social services systems need strategic backup resources at community, national, and global levels if any basic system may collapse due to COVID‐19 and socio‐economic as well as geopolitical negligence in handling post‐pandemic challenges.
Hydrolysis‐Induced InOx on ZnIn2S4 Promotes Selective CO2 Photoreduction over H2 Evolution
Authors: Zhang Xinxin , Wang Xinkui , Shao Yuqing , Dou Zhaolin , Liang Xiaoyu , Ji Min , Wang Min 
Published: November 2022

AbstractMetal sulfides generally show high visible light photocatalytic activity, but lower selectivity in the CO2 photoreduction due to the competitive hydrogen evolution. Here, a partial hydrolysis method is reported to promote the selective photocatalytic CO2 reduction over ZnIn2S4. The ZnIn2S4 was post‐hydrolyzed in an aqueous ammonia solution to form oxide species (ZIS‐[InOx]). Detailed experiment and DFT calculation demonstrated that the post‐hydrolysis treatment facilely prohibits the recombination of photogenerated charge carriers and benefits CO2 activation. Under visible light irradiation, the ZIS‐[InOx] photocatalyst shows enhanced CO2‐to‐CO conversion activity with a CO‐evolving rate of 1771 μmol g−1 h−1, which is about 8 times higher than that over pristine ZIS and 3.5 times higher than that over bulk ZIS/In2O3. More importantly, the post hydrolysis treatment significantly prohibits the hydrogen evolution and increases the CO/H2 ratio from 0.08 over ZIS to 1.8 over ZIS‐[InOx]. This work provides a new strategy to prepare catalysts for photocatalytic CO2 reduction.
Antifungal activity of potato glycoalkaloids and its potential to control severity of dry rot caused by Fusarium sulphureum
Authors: Li Hong , Li Ming , Fan Yanling , Liu Yuhui , Qin Shuhao 
Published: November 2022

AbstractIdentifying novel sources of antifungal agents from common food waste (i.e., green potato peel) could provide an inexpensive alternative for botanical fungicides. Identification of the potato (Solanum tuberosum L.) glycoalkaloids (PGAs) content in the green peel by high performance liquid chromatography (HPLC), and the antifungal activity of PGAs against the potato dry rot pathogen Fusarium sulphureum were evaluated using addition of PGAs to the medium in vitro and injection of it into potato tubers in vivo. The results of HPLC showed that the average content of PGAs per kilogram green potato peel was 2238.76 mg, and the α‐chaconine content was about 1.8 times higher than that of α‐solanine. Antifungal activity test of PGAs in vitro uncovered that mycelium growth rate of F. sulphureum was inhibited in potato dextrose agar (PDA) medium with varying concentrations of PGAs, and the inhibition rate was positively correlated with PGAs concentration. Moreover, PGAs were also capable of reducing the contents of malondialdehyde, total phenols, flavonoids as well as the activities of peroxidase and superoxide dismutase induced by F. sulphureum through inhibiting or killing part of mycelium. These findings suggest that the protective effect of PGAs against potato dry rot might be associated with the direct fungistatic effect on the pathogen. Thus, PGAs can serve as a promising botanical fungicide to substitute, at least partially, the use of synthetic fungicides in the disease management of potato.
An image‐based methodology to evaluate oat panicle architecture
Authors: Berro Inés , Varela Jose , Gutiérrez Lucía 
Published: November 2022

AbstractPanicle size and architecture are traits of major relevance for oat production as they play a key role in conditioning the potential number of grains per spikelet and in consequence grain shape, size, and distribution. The aim of this research was to propose an image‐based strategy and methodology to evaluate oat panicles. Specifically, the goals were to create and deploy the foundations for a high‐throughput methodology to phenotype oat panicles and to determine the optimum number of panicles needed to detect differences between genotypic means for oat panicle traits with high power. A total of 48 genotypes were evaluated in four field experiments with three true replications in two locations and 2 years. Ten panicles per experimental unit were harvested and evaluated with image analysis using MATLAB. Panicle length, width, aspect ratio, compactness, and digital biomass were obtained from the images. The heritability of all panicle traits was high between 0.76 and 0.93. A high power of 0.80 to detect significant differences at an alpha of 0.05 among genotypic means for all panicle architecture traits was reached with the use of six panicles per replication. Our results showed a highly efficient and powerful strategy to study panicle architecture in oat. This methodology could be scaled‐up to efficiently phenotype large populations and provide the basis for understanding panicle architecture and grain morphology in oat.
Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing
Authors: López‐Cánovas Juan L. , Hermán‐Sánchez Natalia , Moreno‐Montilla Maria Trinidad , del Rio‐Moreno Mercedes , Alors‐Perez Emilia , Sánchez‐Frias Marina E. , Amado Víctor , Ciria Rubén , Briceño Javier , de la Mata Manuel , Castaño Justo P. , Rodriguez‐Perálvarez Manuel , Luque Raúl M. , Gahete Manuel D. 
Published: November 2022

AbstractIntroductionAltered splicing landscape is an emerging cancer hallmark; however, the dysregulation and implication of the cellular machinery controlling this process (spliceosome components and splicing factors) in hepatocellular carcinoma (HCC) is poorly known. This study aimed to comprehensively characterize the spliceosomal profile and explore its role in HCC.MethodsExpression levels of 70 selected spliceosome components and splicing factors and clinical implications were evaluated in two retrospective and six in silico HCC cohorts. Functional, molecular and mechanistic studies were implemented in three cell lines (HepG2, Hep3B and SNU‐387) and preclinical Hep3B‐induced xenograft tumours.ResultsSpliceosomal dysregulations were consistently found in retrospective and in silico cohorts. EIF4A3, RBM3, ESRP2 and SRPK1 were the most dysregulated spliceosome elements in HCC. EIF4A3 expression was associated with decreased survival and greater recurrence. Plasma EIF4A3 levels were significantly elevated in HCC patients. In vitro EIF4A3‐silencing (or pharmacological inhibition) resulted in reduced aggressiveness, and hindered xenograft‐tumours growth in vivo, whereas EIF4A3 overexpression increased tumour aggressiveness. EIF4A3‐silencing altered the expression and splicing of key HCC‐related genes, specially FGFR4. EIF4A3‐silencing blocked the cellular response to the natural ligand of FGFR4, FGF19. Functional consequences of EIF4A3‐silencing were mediated by FGFR4 splicing as the restoration of non‐spliced FGFR4 full‐length version blunted these effects, and FGFR4 inhibition did not exert further effects in EIF4A3‐silenced cells.ConclusionsSplicing machinery is strongly dysregulated in HCC, providing a source of new diagnostic, prognostic and therapeutic options in HCC. EIF4A3 is consistently elevated in HCC patients and associated with tumour aggressiveness and mortality, through the modulation of FGFR4 splicing.
Metamaterial‐based highly isolated MIMO antenna system for 5G smartphone application
Authors: Din Iftikhar Ud , Ullah Sadiq , Mufti Naveed , Ullah Rizwan , Kamal Babar , Ullah Raza 
Published: November 2022

SummaryA two‐port multiple‐input‐multiple‐output (MIMO) antenna system operating in the mm‐wave band for 5G applications is presented. The two elements of MIMO structure are separated from each other by 19 mm (1.9
) and excited by microstrip feed. The MIMO elements are circular patches with round cuts at the edges to improve impedance bandwidth. Quadrilateral slot in the ground plane is designed to improve the radiation characteristics of the radiating element having size 18
0.8 mm3. The MIMO design is simulated through CST. The proposed antenna works in 27–29 GHz range, providing a potential bandwidth of 2 GHz. Furthermore a gain is improved from 8.2 to 8.75 dB and efficiency increase from 85% to 88% and high isolation of 64 dB is achieved by placing 4‐elements of metamaterial with size 4.5
18 mm2 in the middle of two circular monopole antennas. The metamaterial gives us a band stop response and act as decoupler and enhance the isolation to reduce mutual coupling. By analyzing the radiation characteristics of the proposed design, in term of reflection coefficient, surface currents, reduced mutual coupling, suitable gain, envelope correlation coefficient (ECC), diversity gain (DG) and radiation pattern, the recommended antenna can be considered a good candidate for 5G applications.
Novel modalities of delivering herbal medicines for wound healing: A review
Authors: Soni Sakshi , Namdeo Shraddha , Agrawal Poornima , Haider Tanweer , Soni Vandana 
Published: November 2022

AbstractBackgroundThroughout the classical era, medicinal plants have already been employed as a resource for medicine and in the healing of wounds. Chronic wounds are linked to significant healthcare and socioeconomic consequences despite standard medication. The development of effective wound‐healing therapies with improved wound repair mechanisms may result from the emergence of innovative wound‐healing techniques utilizing medicinal plants in combination with nanotechnology. This review combines herbal formulations like biodegradable nanoparticles, films, fibres, hydrogels, and ointments with antibacterial, antioxidant, and anti‐inflammatory characteristics with herbal medicines to promote wound healing.ObjectiveThis article aims to provide an overview of the numerous cellular and molecular elements involved in skin healing.FindingsThis article overviews the numerous cellular and molecular elements involved in skin healing. Following the commencement of a tissue lesion, a series of molecular and cellular actions take place to restore the injured tissue. This process is known as regeneration and tissue repair. Sequential events involving the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells result in the exudative, proliferative, and extracellular matrix remodelling stages.ConclusionThe development of tissue edema is aided by exudative processes after damage. By recruiting myofibroblasts and fibroplasia, the proliferative stage aims to decrease the area of tissue damage. The mechanisms of angiogenesis and re‐epithelialization are still observed at this point.
Recursive use of home ranges and seasonal shifts in foraging behavior by a generalist carnivore
Authors: Youngmann Jordan L. , Hinton Joseph W. , Bakner Nicholas W. , Chamberlain Michael J. , D'Angelo Gino J. 
Published: November 2022

AbstractCoyotes (Canis latrans) colonized the southeastern United States over the last century as large predators, including the red wolf (Canis rufus) and eastern cougar (Puma concolor), were extirpated from the region. As a generalist carnivore, the coyote preys on white‐tailed deer (Odocoileus virginianus) and various smaller mammals, birds, and vegetation. While resource selection by coyotes has been well documented at the home‐range scale, little is known about their foraging behavior, which is an important factor in thoroughly understanding influences of coyotes on prey and sympatric carnivores. We assessed third‐order resource selection of coyotes at sites across Alabama, Georgia, and South Carolina during 2015–2016. Using GPS collars, we tracked 41 resident coyotes across four calendar seasons and identified suspected foraging areas using recursive analysis where individuals repeatedly returned to known locations. We found that resident coyotes selected for open landcover types throughout the year, while avoiding primary and secondary roads. Additionally, resident coyotes avoided forested landcover types while selecting for forest edges except from April to June when they foraged within interior forest away from edges. Previous studies have documented substantive predation rates on white‐tailed deer neonates by coyotes, and that fawn mortality may increase in forested landscapes away from forest edge. Our findings indicate that foraging coyotes may select forest cover types during spring where fawns are more vulnerable to predation. Additionally, there has been debate in the literature as to how coyotes obtain consistent levels of deer in their diets outside of fawning and fall hunting seasons. Our study indicates that use of road‐kill carcasses by coyotes was an unlikely explanation for the presence of deer in coyote diets throughout the year, as coyotes in our study were not observed using roads during foraging excursions.
Multisystem inflammatory syndrome and lymphohistiocytic myocarditis after Covid‐19 vaccine in a middle‐aged woman
Authors: Kobayashi Kosuke , Hamatani Yasuhiro , Moriyoshi Koki , Iguchi Moritake , Masunaga Nobutoyo , Terashima Mariko , Abe Mitsuru , Sasahashi Nozomu , Akao Masaharu 
Published: November 2022

AbstractWe describe a 51‐year‐old otherwise healthy woman hospitalized for hypotension, fever, and weakness 4 days after the second‐dose Covid‐19 mRNA vaccine. Elevated inflammatory markers, natriuretic peptide levels and troponin levels, and slightly reduced left ventricular ejection fraction of 50% were noted. We also found the multiple organ damage, including mucocutaneous, gastrointestinal, and neurologic systems. In addition, we revealed the positive results for anti‐nucleocapsid SARS‐CoV‐2 IgG, albeit negative for SARS‐CoV‐2 polymerase chain reaction testing, suggesting the prior asymptomatic Covid‐19 infection. We finally diagnosed her as multisystem inflammatory syndrome after vaccination. Of note, we obtained myocardial specimen from the patients and demonstrated the lymphohistiocytic myocarditis, which is a rare form of myocarditis.
Numerical simulation of fractured horizontal well considering threshold pressure gradient, non‐Darcy flow, and stress sensitivity
Authors: Xiao Honglin , Geng Shaoyang , Luo Hao , Song Linke , Wang Huiqiang , He Xing 
Published: November 2022

AbstractConventional numerical simulators cannot accurately predict the production of fractured horizontal wells in tight sandstone gas reservoirs due to the threshold pressure gradient (TPG) and stress sensitivity. Additionally, non‐Darcy flow in hydraulic fractures further complicates the prediction. Therefore, a numerical simulation model was developed to accurately predict the production of fractured horizontal wells that considers the TPG, non‐Darcy flow, and stress sensitivity using the embedded discrete fracture model. The model was solved using the automatic differentiation framework of MATLAB Reservoir Simulation Toolbox. The numerical simulation demonstrated that the Darcy flow model provided an optimistic prediction of the productivity of fractured gas wells in tight reservoirs. The TPG, non‐Darcy flow, and stress‐sensitive phenomena reduced the productivity of gas wells to varying degrees and severely affected the production of gas wells. The TPG effect, non‐Darcy effect, and stress sensitivity phenomenon reduced the gas well production by 1.66%, 12.9%, and 42.42%, respectively, compared with that of the Darcy flow. In contrast to the conventional Darcy flow model, the model established in this study can accurately predict the production of gas wells in production history matching.
Longitudinal modeling of fasting blood sugar with diabetes: A case study of Adama Hospital Medical College, Ethiopia
Authors: Abdulahi Abdulmenan M. , Aguade Aragaw E. , Yohannis Hunachew K. 
Published: November 2022

AbstractObjectiveThe aim of this study was to evaluate the change in fasting blood sugar (FBS) over time and its determinants in diabetic patients.MethodsA longitudinal data analysis retrospective‐based study was considered with a sample of 312 patients, and the linear mixed effect model was applied.ResultsBased on the linear mixed model, the 3‐month change in time decreases the average FBS level by 0.0111. An increase of one unit of body mass index (BMI) increases the FBS level by 0.0434. Similarly, an increase in blood pressure (DBP) per unit increased the average log FBS level by 0.0005. Secondary and higher education levels lower log FBS levels by 99.41% and 99.45%, respectively, compared with noneducated individuals.ConclusionThe study showed that hypertension history, type of diet, age, status of education, type of drug, body mass index, diastolic blood pressure, and time were statistically significant factors.ImplicationsAccording to the study, eating a healthy diet, maintaining a healthy body weight, and a low blood sugar level are essential to controlling blood sugar and preventing long‐term complications. The government should build an educational institution proportional to the population and open programs to increase awareness about the prevention mechanism of diabetes in communities.
Development of three‐dimensionally printed vascular stents of bioresorbable poly(l‐lactide‐co‐caprolactone)
Authors: Zhao Justin , Song Ge , Zhao Qinghua , Feng Hanqing , Wang Yunbing , Anderson James M. , Zhao Hugh , Liu Qing 
Published: November 2022

AbstractWith the ripening of 3D printing technology and the discovery of a variety of printable materials, 3D‐printed vascular stents provide new treatment options for patients with angiocardiopathy. Bioresorbable stent not only combines the advantages of metallic stent and drug‐coated balloon, but also avoids the disadvantages of them. 3D printing is also an economical and efficient way to produce stents and makes it possible to construct complex structures. In this study, stents made from poly(l‐lactic acid) (PLLA), poly(ε‐caprolactone) (PCL) and poly(l‐lactide‐co‐caprolactone) (PLCL) were manufactured by 3D printing and evaluated for radial strength, crystallinity and molecular weight. PLCL copolymerized by different proportions of lactic acid and caprolactone showed different mechanical and degradation properties. This demonstrated the potential of 3D printing as a low‐cost and high throughput method for stent manufacturing. The PLLA and PLCL 95/5 stents had similar mechanical properties, whereas PLCL 85/15 and PCL stents both had relatively low radial strength. In general, PLCL 95/5 had a faster degradation rate than PLLA. These two materials were made into peripheral vascular bioresorbable scaffolds (BRS) and further studied by additional bench testing. PLCL 95/5 peripheral BRS had superior mechanical properties in terms of flexural/bending fatigue and compression resistance.
Antimicrobial activity and cytotoxicity study of cerium oxide nanoparticles with two different sizes
Authors: Yefimova Svetlana , Klochkov Vladimir , Kavok Nataliya , Tkachenko Anton , Onishchenko Anatolii , Chumachenko Tatyana , Dizge Nadir , Özdemir Sadin , Gonca Serpil , Ocakoglu Kasim 
Published: November 2022

AbstractThe control over bacterial diseases requires the development of novel antibacterial agents. The use of antibacterial nanomedicines is one of the strategies to tackle antibiotic resistance. The study was designed to assess the antimicrobial activity of cerium oxide (CeO2) nanoparticles (NP) of two different sizes (CeO2 NP1 [1–2 nm] and CeO2 NP2 [10–12 nm]) and their cytotoxicity towards eukaryotic cells. The antimicrobial activity, effects of nanoparticles on DNA cleavage, microbial cell viability, and biofilm formation inhibition were analyzed. The impact of cerium oxide nanoparticles on eryptosis of erythrocytes was estimated using annexin V staining by flow cytometry. The newly synthesized CeO2 NP1 and CeO2 NP2 displayed moderate antimicrobial activities. CeO2 NP1 and CeO2 NP2 exhibited single‐strand DNA cleavage ability. CeO2 NPs were found to show 100% microbial cell viability inhibition at a concentration of 500 mg/L. In addition, CeO2 NP1 and CeO2 NP2 inhibited the biofilm formation of S. aureus and P. aeruginosa. Larger cerium oxide nanoparticles were found to be less toxic against erythrocytes compared with the smaller ones. CeO2 nanoparticles demonstrate moderate antimicrobial activity and low cytotoxicity towards erythrocytes, which make them promising antibacterial agents.