bluuebunny/crossref_metadata_2025_split huggingface dataset:
ДОСЛІДЖЕННЯ ЖИРНИХ КИСЛОТ CAMELINA SATIVA (L.) CRANTZ
Authors: Lisova T. O. , Trzhetsynskyi S. D. 
Published: August 2022

Мета роботи – встановлення якісного складу та визначення кількісного вмісту жирних кислот рижію посівного сорту «Славутич».
Матеріали та методи. Об’єкт дослідження – рижію посівного трава та насіння. Сировина вирощена та заготовлена ​​на території Запорізької області влітку 2018 р. Дослідження хімічного складу рижію посівного проводили методом ГХ-МС за допомогою газового хроматографа Agilent 7890B GC System з мас-спектрометричним детектором Agilent 5977 BGC/MSD та хроматографічною колонкою DB-5ms.
Результати й обговорення. Методом ГХ-МС виявлено 11 жирних кислот в сировині рижію посівного, а саме у траві – 5, у насінні – 11. Загальна кількість жирних кислот у траві Camelina sativa (L.) Crantz становить 2,04%, а в насінні – 40,32%. Кількість ненасичених жирних кислот (35,20%) у траві становить майже третину від загального вмісту, де переважає α-ліноленова кислота (24,86%). При цьому кількість ненасичених жирних кислот насіння (86,94%) значно перевищує кількість насичених кислот з домінуванням α-ліноленової (161,03 мг/г, 39,95% від загального вмісту ідентифікованих жирних кислот), паулінової (81,20 мг/г, 20,15%) та лінолевої кислот (73,30 мг/г, 18,19%).
Висновки. На основі проведеного фітохімічного дослідження ідентифіковано та встановлено кількісний вміст жирних кислот трави та насіння рижію посівного сорту Славутич. Отримані результати дозволяють рекомендувати насіння рижію посівного як рослинне джерело поліненасичених жирних кислот з метою створення на його основі ефективних вітчизняних препаратів.
МУЗЕЙНА ПЕДАГОГІКА ТА ЇЇ РОЛЬ У НАВЧАЛЬНОМУ ПРОЦЕСІ МЕДИЧНИХ ЗАКЛАДІВ ВИЩОЇ ОСВІТИ
Authors: Федонюк Л. Я. , Ярема О. М. , Ястремська С. О. 
Published: August 2022

За сучасних умов реформування української освітньої системи постає питання щодо нових підходів до організації і змісту навчально-виховної діяльності. Важливе місце серед них посідає один із перспективних напрямів сучасної педагогіки – музейна педагогіка, що вирішує проблеми формування особистості, а саме: залучення учнівської та студентської молоді до дослідницької діяльності засобами музейної експозиції з використанням інформаційних технологій, розвиток їх дослідницьких умінь і творчих здібностей, вироблення здатності до самостійних суджень та оцінок, навичок критичного мислення. Музейна педагогіка відіграє велику роль у системі освіти та сприяє всебічному розвитку особистості студента. Метою створення навчальних музеїв є отримання найповнішого уявлення про зміст живої природи, що нас оточує, морфологію людини, тварин, рослин, а також їх вважають осередком освіти і виховання. У Тернопільському національному медичному університеті імені І. Я. Горбачевського МОЗ України є ряд музеїв навчального профілю: музей кафедри анатомії людини, музей кафедри патологічної анатомії з секційним курсом та судовою медициною, навчально-біологічний музей імені І. І. Яременка. Музей кафедри анатомії людини містить унікальну колекцію анатомічних препаратів, які відображають форму органів, їх топографічні взаємовідносини, проекції судин і нервів, що слугують невід’ємною теоретичною базою для студентів медичного, стоматологічного та фармацевтичного факультетів, а також для студентів Навчально-наукового інституту медсестринства. Досягти високого практичного рівня професійної підготовки неможливо і без вивчення музейних макропрепаратів кафедри патологічної анатомії з секційним курсом та судовою медициною. Навчально-біологічний музей імені І. І. Яременка представляє натуральні об’єкти та їх зображення, які створюють найповніше уявлення про взаємозв’язок людини з навколишнім природним середовищем. Отже, музеї університету займають вагоме місце у навчально-виховному процесі, завдяки їм теорія і практика дають високий позитивний результат у формуванні професіоналізму лікаря.
Detection of Carotid Artery Stenosis Based on Video Motion Analysis for Fast Screening
Authors: Tsai Cheng‐Hsuan , Huang Ching‐Chang , Hsiao Hao‐Ming , Hung Ming‐Ya , Su Guan‐Jie , Lin Li‐Han , Chen Ying‐Hsien , Lin Mao‐Shin , Yeh Chih‐Fan , Hung Chi‐Sheng , Kao Hsien‐Li 
Published: August 2022

Background
Carotid artery stenosis (CAS) is a common cause of ischemic stroke, and the early detection of CAS may improve patient outcomes. Carotid Doppler ultrasound is commonly used to diagnose CAS. However, it is costly and may not be practical for regular screening practice. This article presents a novel noninvasive and noncontact detection technique using video‐based motion analysis (VMA) to extract useful information from subtle pulses on the skin surface to screen for CAS.

Methods and Results

We prospectively enrolled 202 patients with prior carotid Doppler ultrasound data. A short 30‐second video clip of the neck was taken using a commercial mobile device and analyzed by VMA with mathematical quantification of the amplitude of skin motion changes in a blinded manner. The first 40 subjects were used to set up the VMA protocol and define cutoff values, and the following 162 subjects were used for validation. Overall, 54% of the 202 subjects had ultrasound‐confirmed CAS. Using receiver operating characteristic curve analysis, the area under the curve of VMA‐derived discrepancy values to differentiate patients with and without CAS was excellent (area under the curve, 0.914 [95% CI, 0.874–0.954];
P
<0.01). The best cutoff value of VMA‐derived discrepancy values to screen for CAS was 5.1, with a sensitivity of 87% and a specificity of 87%. The diagnostic accuracy was consistently high in different subject subgroups.

Conclusions
A simple and accurate screening technique to quickly screen for CAS using a VMA system is feasible, with acceptable sensitivity and specificity.
Home-Based Transcranial Direct Current Stimulation to Enhance Cognition in Stroke: Randomized Controlled Trial
Authors: Ko Myoung-Hwan , Yoon Ju-Yul , Jo Yun-Ju , Son Mi-Nam , Kim Da-Sol , Kim Gi-Wook , Won Yu Hui , Park Sung-Hee , Seo Jeong-Hwan , Kim Yun-Hee 
Published: August 2022

Background:
Transcranial direct current stimulation (tDCS) is a promising tool for improving poststroke cognitive function. Home-based rehabilitation is increasingly required for patients with stroke, and additional benefits are expected if supplemented with remotely supervised tDCS (RS-tDCS). We evaluated the cognitive improvement effect and feasibility of RS-tDCS in patients with chronic stroke.

Methods:
Twenty-six patients with chronic stroke and cognitive impairment (Korean version of the Montreal Cognitive Assessment [K-MoCA] score <26) were randomized into real and sham RS-tDCS groups and underwent concurrent computerized cognitive training and RS-tDCS. Patients and caregivers underwent training to ensure correct tDCS self-application, were monitored, and treated 5 d/wk for 4 weeks. We investigated several cognition tests including K-MoCA, Korean version of the Dementia Rating Scale-2, Korean-Boston Naming Test, Trail Making Test, Go/No Go, and Controlled Oral Word Association Test at the end of the training sessions and one month later. Repeated-measures ANOVA was used for comparison between the groups and within each group. The adherence rate of the appropriate RS-tDCS session was also investigated.

Results:

In within-group comparison, unlike the sham group, the real group showed significant improvement in K-MoCA (
P
real
=0.004 versus
P
sham
=0.132), particularly in patients with lower baseline K-MoCA (K-MoCA
10–17
;
P
real
=0.001 versus
P
sham
=0.835, K-MoCA
18–25
;
P
real
=0.060 versus
P
sham
=0.064) or with left hemispheric lesions (left;
P
real
=0.010 versus
P
sham
=0.454, right;
P
real
=0.106 versus
P
sham
=0.128). In between-group comparison, a significant difference was observed in K-MoCA in the lower baseline K-MoCA subgroup (K-MoCA
10–17
;
P
time×group
=0.048), but no significant difference was found in other cognitive tests. The adherence rate of successful application of the RS-tDCS was 98.4%, and no serious adverse effects were detected.

Conclusions:
RS-tDCS is a safe and feasible rehabilitation modality for poststroke cognitive dysfunction. Specifically, RS-tDCS is effective in patients with moderate cognitive decline. Additionally, these data demonstrate the potential to enhance home-based cognitive training, although significant differences were not consistently found in between-group comparisons; therefore, further larger studies are needed.

Registration:

URL:
https://cris.nih.go.kr
; Unique identifier: KCT0003427.
A comprehensive review of fault diagnosis and fault-tolerant control techniques for modular multi-level converters
Authors: Ahmad Faizan , Adnan Muhammad , Amin Arslan Ahmed , Khan Muhammad Gufran 
Published: August 2022

Background Many faults occur in the modular multi-level converters (MMCs), including unbalancing capacitor voltage, lower and upper arm unbalancing, the line to line voltage unbalancing, sensors and actuators fault, system fault, and sub-modules fault in high as well as medium voltage applications. Introduction Several fault-tolerant approaches are presented to overcome these problems, such as active fault-tolerant control system (AFTCS), passive fault-tolerant control system (PFTCS), hybrid fault-tolerant control system (HFTCS), redundant system technique, special power circuit with the controller, and zero sequence voltage methods, which we will explain extensively in this article. Methodology This review emphasizes the types of faults in the MMCs and discusses the protection methods under failure conditions. The MMC is more popular in high voltage applications because it not only improves the quality of the grid but also has good harmonic performance in high power transmission. There is no need for any isolated dc sources to operate it. When faults are removed, the efficiency and reliability of the system will be increased. Results This extensive explanation of the current literature on MMC fault diagnosis and control techniques will conclude which methods provide a more valuable solution. Finally, this paper discusses the best approach to reduce MMC faults and provides a future research direction to the readers.
Effect and mechanism of a novel Mg-Nd-Gd-Sr alloy on osteogenic differentiation of bone marrow mesenchymal stem cells
Authors: Li Qiangqiang , Yang Qinglin , Liu Xiaorong , Liang Wenqiang , Zhang Xiaobo , Wang Yongping 
Published: August 2022

We investigated the effect and mechanism of a novel Mg-3Nd-1Gd-0.3Sr-0.2Zn-0.4Zr (abbreviated to Mg-Nd-Gd-Sr) alloy on the osteogenic differentiation of bone marrow mesenchymal stem cells extracted from Sprague-Dawley rats. Cultured cells were divided into five groups: a control group cultured in osteogenic induction medium alone without Mg-Nd-Gd-Sr alloy extract, and four experimental groups cultured in the same medium with 25%, 50%, 75%, and 100% Mg-Nd-Gd-Sr alloy extracts, respectively. After 14 days of culture, ALP activity was determined and expressions of osteogenesis-related factors Runx2, OCN, and OPN at the mRNA level and Runx2, OCN, and OPN at the protein level were detected by RT-PCR and western blot, respectively. After 21 days of culture, mineralized nodules were detected by alizarin red staining. The results showed that bone marrow mesenchymal stem cells from Sprague-Dawley rats were successfully isolated in vitro using the whole bone marrow adherence method. Flow cytometry revealed that the cells expressed high levels of CD44 and CD90, but low levels of CD31 and CD45. Alizarin red staining indicated the formation of mineralized nodules in all five groups. Compared with the control group, the number of mineralized nodules was increased significantly in the four experimental groups ( p < 0.05). The ALP activity in each group was significantly higher on day 14 than on day 7, and was significantly higher in the four experimental groups compared with the control group ( p < 0.05). Moreover, the ALP activity was highest when the concentration of Mg-Nd-Gd-Sr alloy extract was 75% ( p < 0.05). RT-PCR results showed that, compared with the control group, the mRNA expression of Runx2, OPN, and OCN was significantly higher in the four experimental groups ( p < 0.05), and the highest mRNA expression of Runx2, OPN, and OCN was observed in the 75% experimental group ( p < 0.05). Western blotting showed that Mg-Nd-Gd-Sr alloy extract significantly increased the protein expression of Runx2, OCN, and OPN compared with the control group ( p < 0.05). Our data indicate that the novel Mg-Nd-Gd-Sr alloy can promotes the osteogenic differentiation of bone marrow mesenchymal stem cells isolated from Sprague-Dawley rats. During this process, there is an increase in the expressions of Runx2, OPN, and OCN mRNAs and Runx2, OCN, and OPN proteins.
Prevalence of Cardiovascular Diseases Among Breast Cancer Survivors: Findings From the NHANES 2003-2018
Authors: Kim Youngdeok , Franco R. Lee , Lucas Alexander R. , Sutton Arnethea L. , LaRose Jessica G. , Kenyon Jonathan , Via Jeremy , Cheng Richard K. , D’Agostino Ralph, B. , Sheppard Vanessa B. , Hundley W. Gregory 
Published: August 2022

Purpose To examine the prevalence of cardiovascular diseases (CVD) among breast cancer (BC) survivors. Design Cross-sectional observational study using the data from the National Health and Nutrition Examination Survey (NHANES) 2003–2018. Setting United States (US). Subjects A nationally representative sample of US women with a history of BC. Measures Self-reported CVD status (i.e., coronary artery disease (CAD), heart failure, and stroke) and time of the CVD diagnosis were used to categorize BC survivors into three groups: No CVD, preexisting CVD, and post-acquired CVD after BC diagnosis. Analysis The prevalence of CVD among BC survivors were estimated by demographic characteristics. Complex sampling design of the NHANES was accounted to estimate the population-level prevalence. Results A total of 658 BC survivors were identified, representing 3.01% (≈3.4 million) of the US women aged ≥18 years old. Of those, ≈6% (≈.2 million) had preexisting CVD and ≈11% (≈.4 million) had at least one CVD diagnosed after BC diagnosis, with an average time elapsed ranging from ≈5 years for heart failure to ≈9 years for CAD and stroke. The prevalence of CVD among BC survivors differed by demographic characteristics including age, education, marital status, menopausal, and physical activity levels. Conclusion Our findings suggest that BC survivors are at risk of suffering from CVD and public health strategies for the long-term management of CVD risk factors in this vulnerable population group is recommended.
Psychological Factors Associated With Fear of Falling Avoidance Behavior in Parkinson’s Disease: The Role of Depression, Anxiety, and Catastrophizing
Authors: Rider John V , Longhurst Jason K , Lekhak Nirmala , Navalta James W , Young Daniel L , Landers Merrill R 
Published: August 2022

Purpose The purpose of this study was to examine the relationship between psychological factors (depression, anxiety, and catastrophizing) and fear of falling avoidance behavior (FFAB) among individuals with Parkinson’s disease (PD). Methods A secondary analysis of cross-sectional data from 59 individuals with PD using hierarchical multiple regression. Results Disease severity (Movement Disorder Society - Unified PD Rating Scale) and catastrophizing (Consequences of Falling Questionnaire (CoF)) explained approximately 48.2% of the variance in the FFAB Questionnaire scores ( P < .001). Catastrophizing was the only significant psychological variable ( P < .001). The damage to identity subscale of the CoF was significant in the final model ( P < .001). Conclusions Catastrophizing about the consequences of falls explained the largest portion of variability in FFAB after controlling for disease severity. Catastrophizing about the immediate consequences of falling may play a prominent role in FFAB and may be a potential treatment target for mitigating FFAB.
Experience With Pre-procedural Hemostatic Medications versus Platelet Transfusion in Patients With Platelet Storage Pool Deficiency
Authors: Lundy Katharine A. , Rabatin Abigail , Davidson Erica R. , Li Junan , Snider Melissa J. , Kraut Eric H. 
Published: August 2022

Background Storage pool deficiency (SPD) is a rare bleeding disorder characterized by reduction in the number of delta granules within platelets, interfering with hemostasis. Current literature lacks well-designed studies from which to draw concrete conclusions regarding pre-procedural management of bleeding complications. Objective: The purpose of this study is to describe bleeding and safety outcomes of SPD patients receiving either pre-procedural platelet transfusions or platelet-sparing regimens. Methods: An exploratory retrospective cohort study was conducted among SPD patients, comparing major bleeding events between those who received platelet transfusion and those who received desmopressin, tranexamic acid, and/or aminocaproic acid within 24 hours prior to procedure. Results: Rates of major bleeding were not found to be higher among patients who received a platelet-sparing regimen [platelet-sparing: 2/25 (8%); platelet transfusion: 2/29 (6.9%); P = .99]. Incidence of non-major bleeding was higher in the platelet transfusion group, but this was not statistically significant [platelet-sparing: 0/25 (0%); platelet transfusion: 3/29 (10.3%); P = .24]. Treatment-related adverse effects were observed following 8 of 54 procedures (14.8%). Conclusion: Use of a platelet-sparing regimen was not associated with a significantly higher incidence of major or non-major bleeding events. Future prospective trials are recommended to compare outcomes between therapies.
Revision total hip arthroplasty using a Kerboull-type acetabular reinforcement device and allogeneic structural bone graft
Authors: Fujimoto Yusuke , Nakamura Shunsuke , Ijuin Toshiro , Iuchi Tomohiro , Nakajo Masahide , Taniguchi Noboru 
Published: August 2022

Purpose: One of the major problems in revision total hip arthroplasty (THA) is severe acetabular bone loss. The aim of our study was to evaluate the clinical outcomes of revision THA using a Kerboull-type reinforcement device (KT plate) and allogeneic structural bone graft. Methods: This retrospective study evaluated 48 hips that underwent revision THA using a KT plate and allogeneic structural bone graft between 2008 and 2016, with a median follow-up of 6.2 years (range 3–12.6 years). Functional outcome was assessed using the Japanese Orthopaedic Association (JOA) hip score. Postoperative and follow-up radiographs were compared to assess migration and breakage of the implant. Results: The mean JOA hip score improved from 45.6 (±16.3) points before surgery to 72.1 (±11.9) points at the most recent follow-up examination ( p < 0.001). Two hips (4.2%) underwent re-revision THA because of cup loosening due to breakage of the KT plate. A total of 13 hips (27.1%) were classified as radiological failures. Binomial logistic regression analysis showed that a Kawanabe classification of stage 4, which indicates massive bone defects in the weight-bearing area, was a risk factor for radiological failure (odds ratio: 4.57; 95% confidence interval: 1.01–26.35). Conclusions: A KT plate with an allogeneic structural bone graft is a useful method of acetabular reconstruction in revision THA that restores bone stock and improves hip function. Our findings indicated that a Kawanabe classification of stage 4 was a risk factor for radiological failure of the implant.
Protective effects of Panax ginseng against doxorubicin-induced cardiac toxicity in patients with non-metastatic breast cancer: A randomized, double-blind, placebo-controlled clinical trial
Authors: Hamidian Malihe , Foroughinia Farzaneh , Haghighat Shirin , Attar Armin , Haem Elham 
Published: August 2022

Introduction Anthracycline-based chemotherapy increases the risk of cancer therapeutics-related cardiac dysfunction. Recently, evidences from in vitro experiments and animal studies have shown that ginsenosides may exert cardiovascular protection against cancer therapeutics-related cardiac dysfunction. Here, we aimed to evaluate this effect in a clinical situation. Methods In this randomized, double-blind, placebo-controlled clinical trial, women with non-metastatic breast cancer whose left ventricular ejection fraction was ≥ 50% were randomly assigned in 1:1 ratio to receive ginseng (1 g/day) or placebo besides standard chemotherapy. Echocardiographic measurements were performed at baseline, after the fourth, and eighth chemotherapy cycles. High-sensitive cardiac troponin I was assessed at baseline and after the 4th cycle. The primary endpoint of the study was change in left ventricular ejection fraction. Cancer therapeutics-related cardiac dysfunction was defined as a drop in left ventricular ejection fraction of ≥ 10% from baseline. Results Results from 30 patients were included in the final analysis (15 patients in each group). In the intervention and control groups, left ventricular ejection fraction was dropped from 62.0 ± 0.9% to 60.7 ± 1.0% (difference = −1.3 ± 1.1%) and from 63.27 ± 1.1% to 58.0 ± 1.3% (difference = −5.27 ± 0.8%), respectively (difference = 3.97%, p = 0.006) at the end of the fourth cycle of chemotherapy. After the eighth cycle of chemotherapy, the mean left ventricular ejection fraction was increased by 0.8 ± 1.3% from baseline in the intervention group, whereas the placebo group experienced a reduction of −7.3 ± 1.4% (difference = 8.1%, p-value < 0.001). None of the patients in the ginseng group in comparison to 1(6.7%, p-value = 0.5) and 5 (33.3%, p-value = 0.02) patients in the placebo group developed cancer therapeutics-related cardiac dysfunction after the fourth and eighth cycles, respectively. High-sensitive cardiac troponin I levels were not significantly different between groups. Conclusions Prophylactic ginseng supplementation may protect against doxorubicin-induced early cancer therapeutics-related cardiac dysfunction and early decline in left ventricular ejection fraction in breast cancer patients.