bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pemetaan Agroklimat dengan Menggunakan Metode Klasifikasi Iklim Oldeman
Authors: Aqasha Raechan Anam  
Published: November 2022

Indonesia yang merupakan negara agraris, sangat memerlukan informasi iklim terutama klasifikasi iklim pada setiap wilayahnya. Sistem klasifikasi iklim yang banyak digunakan di Indonesia adalah klasifikasi Oldeman. Klasifikasi Oldeman digunakan karena mengaitkan hubungan antara iklim, jenis tanaman, dan waktu tanam yang sesuai di suatu tempat. Metode yang digunakan dalam penelitian ini adalah analisis deskriptif terhadap data curah hujan dengan rentang waktu dari tahun 1991 hingga 2020 (10 tahun) terdapat beberapa data curah hujan yang hilang (missing data) sehingga diperlukannya tahap pencarian data curah hujan yang hilang dengan menggunakan rumus mencari missing data, menganalisis data dan pemetaan pos hujan. Hasil penelitian yang didapatkan dari observasi 24 stasiun pos hujan di wilayah Kabupaten Tegal menunjukkan rata-rata curah hujan bulanan memiliki bulan basah (> 200 mm) lebih banyak dibandingkan bulan kering (< 100 mm) yaitu total rata-rata perbulannya 6 berbanding 5. Dari peta Klasifikasi Oldeman wilayah Kabupaten Tegal menunjukkan sebagian besar masuk dalam zona iklim C3 dengan kondisi geografisnya didominasi dataran rendah , yang berarti setahun hanya ditanami padi satu kali dan untuk tanaman palawija disarankan untuk tidak ditanami di bulan kering dengan total desa yang mengalami berjumlah 134 desa dengan Kecamatan margasari, Balapulang, Jatinegara, Lebaksiu, Jatibarang, Slawi, Pangkah, Dukuhwaru, Kedungbanteng, dan Adiwerna.
Islamic Values Integrated in Chemistry Module for Senior Highschool Student in North Sumatera
Authors: Anggara Mhd Burhan , Husnitha Effi Nurma 
Published: November 2022

The chemistry module which integrated with Islamic values has already developed in thermochemistry and reaction rate. The aim of this research is to find the availability of Islamic values in student’s handbook, the proper of chemistry module design based on BSNP criteria, and the response to chemistry module which integrated with Islamic values to teacher and university student. This research used the method of research and development. It consists of 3 steps which were analysis, design, and development. The instruments were checklist, questionaire based on BSNP criteria, and response questionnaire. The result shown the lack of Islamic value in student’s handbook, chemistry module design was proper to used because it got the BSNP’s criteria. The teacher and university student’s response are good and need no revision.
Relationship Of Gentamycin Antibiotic Exposure To: Escherichia Coli Bacteria Resistant To Antibiotic Gentamycin And Escerichia Coli ESBL In Vitro
Authors: Kusumawati Diah Retno 
Published: November 2022

Background: The development of bacteria that have been resistant to antibiotics can complicate the treatment process. Either causes of antibiotic resistance is inappropriate use of antibiotics. Gentamycin is an aminoglycoside-derived antibiotic which its role is very significant for gram-negative bacteria. Repeated use of gentamycin antibiotics can cause changes the effectiveness of gentamycin so that non ESBL-Gentamycin susceptible Escherichia Coli will change into ESBL-Gentamycin resistant Escherichia coli. Objective: This study aims to prove that repeated exposure to Gentamycin in vitro will change non ESBL-Gentamycin susceptible Escherichia Coli into ESBL Gentamycin resistant Escherichia Coli. Methods: This was an experimental study with 30 samples of non ESBL-Gentamycin susceptible Escherichia coli isolates identified from the Phoenix. Non ESBL- Gentamycin susceptible Escherichia coli was tested by giving exposure to Gentamycin for 14 days, then ESBL screening was tested by Cefotaxime exposure to the results of Gentamycin exposure. Result: There were 4 isolates of Escherichia coli which experienced changes in phenotype into Gentamycin resistant Escherichia coli. The rest of it still susceptible to Gentamycin on days 2, 4 and 10. Furthermore, the Escherichia coli isolates were both susceptible to Gentamycin and those that had phenotypic changes become resistant to Gentamycin after exposed to Cefotaxime as an ESBL screening. There are 8 (26.7%) isolates that are still susceptible to Cefotaxime and 18 (60%) isolates that have been transformed into ESBL-Gentamycin susceptible Escherichia coli. Isolates of 4 (13.3%) Gentamycin-resistant Escherichia coli are then exposed to Cefotaxime and obtained all isolates is resistant to Cefotaxime. Conclusion: Repeated exposure of Gentamycin for 14 days in vitro was not significantly related to the phenotypic changes of non ESBL-Gentamycin susceptible Escherichia coli isolates into ESBL-Gentamycin resistant Escherichia coli (P = 0.550, Phi=0.237).

Keywords: Escherichia coli, Susceptible, Resistant, Gentamycin, ESBL
Islamic Principles in Mental Medicine
Authors: Abdillah Yahya Nur , Algristian Hafitd , Azizah Nur 
Published: November 2022

Background: The religion of monotheism is the religious instinct of every human being as a creature created by Allah SWT. One of the mental health therapies is religion. Islam is the prevailing religion in almost 56 nations around the globe and has more than 1.2 billion adherents. Islam speaks to an all-encompassing way of life and agrees with its supporters' expansive extent (Tzeferakoz, 2017). The development of psychiatry in Islam has several reviews. Many Islamic figures contributed to treating mental illness long before Western figures discovered it. At the time of the Prophet Muhammad SAW, there was also a treatment for mental illness based on the Qur'an. This article will mention several forms of worship as psychotherapy. Objective: The purpose of this article is to determine the role of the Islamic Principle in Mental Medicine. Methods: The design of this research is a literature review or library review, which is a systematic, direct, and reproducible research method by identifying, evaluating, and synthesizing published research. Result: Islamic principles in mental medicine consist of tawheed religion as mental therapy, worship as human psychotherapy, islamic psychotherapy to help psychiatric treatment and healing process. Conclusion: There are five ways of prayer that a Muslim can do as psychological therapy, namely: Saalat, Dhzikr, reading the Qur'an, Shaum, and Hajj. In an Islamic intellectual, there is a discipline of Islamic Psychotherapy that is an integral part of Islamic Psychotherapy; Istinbath, Iqtibas, and Istiqro.
Clinical Forensic Assessment of Victim with Sharp Force Injury (A Case Report)
Authors: Putri Jeanaya Hedya Alfara 
Published: November 2022

Background: Violence or trauma committed against living victims can take many different forms, including blunt force, sharp force, or other types of injury. Because sharp weapons are simple to get, violent criminal acts frequently involve them. Homicide, suicide, and accidents can all result in deaths from sharp items. Objective: This study aims to dtermine the diagnosis wound qualification on the examination on patient in the emergency room of the Bhayangkara H.S. Samsoeri Mertojoso Hospital. Methods: The method of diagnosis uses a clinical assessment and based on Criminal Code’s Criteria. Result: A 61-year-old male victim with the initials JA who claimed to have experienced sharp force injury was reported. Upon inspection of the victim, an open wound of approximately 3 cm in length, 1 cm in width, and approximately 2 cm in depth was discovered on the outside left upper arm. The patient got wound hecting and medicine to reduce the pain. After that the patient release from hospital. Conclusion: Wounds on the patient's body are criminally caused injuries that fall under the category of minor abuse, meaning they don't make the victim sick or make it difficult for them to accomplish their jobs.
ANALISIS KESALAHAN AFIKS PADA BERITA BABE.COM PRIODE JANUARI-APRIl 2020
Authors: Meita Ardya M.Rais Almajid, Witriana, 
Published: November 2022

Abstract

This study aims to describe the writing errors that are in the media Babe.com, especially the affixation section and then can be corrected in the future. This study is categorized as a qualitative study using descriptive methods by analyzing error data and then presented in the form of describing data analysis. The data collection technique was conducted in the study of literature and documentation by photographing, listening, and taking notes. Content analysis technique is used to describe errors in depth. The analysis found three types of affixation errors, the first prefix there were 12 errors. Both suffixes have 7 errors. Third Confix, there are 19 errors.
Abstrak
Penelitian ini bertujuan untuk dapat mendiskripsikan kesalahan tulisan yang berada pada media Babe.com khususnya bagian afiksasi untuk kemudian dapat diperbaiki kedepanya. Penelitian ini dikategirkan sebagai penelitian kualitatif dengan menggunakan Metode deskriptif dengan cara menganalis data kesalahan kemudian disajikan dalam bentuk memaparkan analisis data. Teknik pengambilan data dilakukan stdudi pustaka dan dokumentasi dengan cara memotret, simak, dan mencatat. Teknik analisis isi digunakan untuk mendeskripsikan kesalahan secara mendalam. Hasil analisis ditemukan tiga jenis kesalahan afiksasi yang pertama prefiks terdapat 12 kesalahan. Kedua sufiks terdapat 7 kesalahan. Ketiga Konfiks terdapat 19 kesalahan.
Kata Kunci: Bahasa, Kesalahan afiksasi
The Influence of Flexural Reinforcement Yielding on the Shear Strength of Reinforced Concrete Beams with and without Shear Reinforcement
Authors: Monserrat López Andrea , Miguel Sosa Pedro 
Published: November 2022

Statically indeterminate structures such as continuous beams allow redistribution of internal forces. For increasing loads after yielding of the flexural reinforcement, shear forces may increase, making it possible to reach shear failures after the full flexural capacity of the structure is developed.
An extensive experimental programme consisting of 30 shear tests (15 cantilever tests and 15 continuous beam tests) was carried out to assess the shear strength of reinforced concrete beams with and without shear reinforcement. Some of the tests were designed to fail in shear after yielding of the flexural reinforcement. The main objective of this experimental study was analysing the influence of large flexural strains on shear strength.
The tests were instrumented by means of surface measurements using Digital Image Correlation (DIC). These measurements allowed controlling the evolution of strains at concrete surface to obtain the rotation of the plastic hinges and tracking the development and kinematics of the critical shear crack to obtain, by accounting for suitable constitutive models, the contribution of the various shear-transfer actions.
The analysis of the test results confirmed the reduction of shear strength provided by concrete with increasing flexural rotation both in tests with and without shear reinforcement. Moreover, this shear strength component weakened for increasing shear reinforcement ratios. The test results were compared with the shear strength values predicted by different design codes, showing that these formulations did not properly capture the loss of shear strength caused by plastic deformation. The proposed simplified method to calculate the shear strength of the plastic hinges accounting for the plastic rotation demand shows consistent agreement for the experimental results.
“In medio stat virtus”: Insights into hybrid E/M phenotype attitudes
Authors: Canciello Angelo , Cerveró-Varona Adrián , Peserico Alessia , Mauro Annunziata , Russo Valentina , Morrione Andrea , Giordano Antonio , Barboni Barbara 
Published: November 2022

Epithelial-mesenchymal plasticity (EMP) refers to the ability of cells to dynamically interconvert between epithelial (E) and mesenchymal (M) phenotypes, thus generating an array of hybrid E/M intermediates with mixed E and M features. Recent findings have demonstrated how these hybrid E/M rather than fully M cells play key roles in most of physiological and pathological processes involving EMT. To this regard, the onset of hybrid E/M state coincides with the highest stemness gene expression and is involved in differentiation of either normal and cancer stem cells. Moreover, hybrid E/M cells are responsible for wound healing and create a favorable immunosuppressive environment for tissue regeneration. Nevertheless, hybrid state is responsible of metastatic process and of the increasing of survival, apoptosis and therapy resistance in cancer cells. The present review aims to describe the main features and the emerging concepts regulating EMP and the formation of E/M hybrid intermediates by describing differences and similarities between cancer and normal hybrid stem cells. In particular, the comprehension of hybrid E/M cells biology will surely advance our understanding of their features and how they could be exploited to improve tissue regeneration and repair.
Long-term efficacy and safety of sirolimus for retinal astrocytic hamartoma associated with tuberous sclerosis complex
Authors: Zhang Chen-Xi , Xu Kai-Feng , Long Qin , Zhang Xiao , Yang Zhi-Kun , Dai Rong-Ping , Zhang Zhi-Qiao 
Published: November 2022

Mammalian target of rapamycin (mTOR) inhibitors (sirolimus or everolimus) have been demonstrated effective in reducing the size of tuberous sclerosis complex (TSC)-associated retinal astrocytic hamartoma (RAH) in short term. To investigate the long-term efficacy and safety of sirolimus on TSC-associated RAH, 13 TSC-associated RAH patients (59 RAH lesions) who received sirolimus therapy for at least 2 years were retrospectively enrolled in this study. Changes in the maximal thickness (MT) of RAH on optical coherence tomography and the longest base diameter (LBD) of RAH on color fundus photography were assessed. The results showed that for a mean follow-up of 39 months, sirolimus was associated with a mean reduction of 14.6% in MT and 6.8% in LBD of RAHs. The main impacts of sirolimus occurred within the first 6–12 months, with 14.8% reduction in MT and 4.7% reduction in LBD. Mouth ulceration (10 [76.9%]) and acne (9 [69.2%]) were the most common adverse events. These follow-up data support the long-term use of sirolimus in TSC-associated RAH patients, and persistent use of sirolimus possibly prevents tumor regrowth.
Human occupational intensity and palaeoecology at Klasies River from MIS 5–3: Preliminary taphonomic analyses of faunal remains from the Deacon and Wurz excavations
Authors: Reynard Jerome P. 
Published: November 2022

Klasies River is a key site in understanding the behaviour of coastal foragers in the southern Cape of South Africa. Faunal remains from Klasies River, recovered from an almost 70,000 year sequence over the Late Pleistocene, are a valuable dataset in investigating subsistence and occupational dynamics, yet few taphonomic studies have been conducted on the fauna from Klasies River. Here, the first taphonomic analyses of faunal remains from the Deacon and Wurz excavation is presented. The aim of this paper is to link occupational patterns during the Late Pleistocene at Klasies River with coastal ecology using taxonomic data from previous studies, and recently analysed taphonomic data. Taphonomic analyses of samples from the MSA II Lower, the Howiesons Poort and the MSA III periods were used to examine occupational intensity based on proportions of anthropogenic and zoogenic bone surface modification, trampling marks, transverse fractures and faunal density. Declining foraging efficiency or subsistence intensification was also investigated using indicators for expanded diet breadth (e.g., small fauna exploitation and increases in juveniles), more intensive marrow extraction and evidence for greater foraging distances. Herbivore functional types and dietary preferences were examined using taxonomic data and these show three main ecological phases at Klasies River: the MSA I; the upper and lower MSA II; and the HP and MSA III phases. Taphonomic data show increased occupational intensity in the MSA II Lower, with subsistence intensification also more evident here than other layers. Trampling data suggests that occupational intensity was greater in the earlier Howiesons Poort than later phase with little evidence of declining foraging efficiency then. The data indicate that, while humans contributed significantly to the MSA III assemblage, carnivores were the main accumulators here suggesting lower occupational intensity in this phase. The results of this study shows a possible link between increased occupational intensity and declining foraging efficiency at Klasies River but larger taphonomic samples are needed to explore this relationship further.
Endocrine system involvement in patients with RASopathies: A case series
Authors: Siano M. A. , Pivonello R. , Salerno M. , Falco M. , Mauro C. , De Brasi D. , Klain A. , Sestito S. , De Luca A. , Pinna V. , Simeoli C. , Concolino D. , Mainolfi Ciro Gabriele , Mannarino T. , Strisciuglio P. , Tartaglia M. , Melis D. 
Published: November 2022

Background and ObjectivesEndocrine complications have been described in patients affected by RASopathies but no systematic assessment has been reported. In this study, we investigate the prevalence of endocrine disorders in a consecutive unselected cohort of patients with RASopathies.Study Design72 patients with a genetically confirmed RASopathy (Noonan syndrome [NS], N=53; 29 LEOPARD syndrome [LS], N=2; cardiofaciocutaneous syndrome [CFCS], N=14; subjects showing co-occurring pathogenic variants in PTPN11 and NF1, N=3) and an age- and sex-matched healthy controls were included in the study. Endocrine system involvement was investigated by assessing the thyroid function, pubertal development, auxological parameters, adrenal function and bone metabolism.ResultsShort stature was detected in 40% and 64% of the NS and CFCS subcohorts, respectively. Patients showed lower Z-scores at DXA than controls (p&lt;0.05) when considering the entire case load and both NS and CFCS groups. Vitamin D and Calcitonin levels were significantly lower (p&lt; 0.01), Parathormone levels significantly higher (p&lt;0.05) in patients compared to the control group (p&lt;0.05). Patients with lower BMD showed reduced physical activity and joint pain. Finally, anti-TPO antibody levels were significantly higher in patients than in controls when considering the entire case load and both NS and CFCS groups.ConclusionsThe collected data demonstrate a high prevalence of thyroid autoimmunity, confirming an increased risk to develop autoimmune disorders both in NS and CFCS. Reduced BMD, probably associated to reduced physical activity and inflammatory cytokines, also occurs. These findings are expected to have implications for the follow-up and prevention of osteopenia/osteoporosis in both NS and CFCS.
Clinical diagnostic value of liquid chromatography-tandem mass spectrometry method for primary aldosteronism in patients with hypertension: A systematic review and meta-analysis
Authors: Hua Kai-Fang , Wu Yan-Hui , Zhang Shi-Ting 
Published: November 2022

BackgroundPrimary aldosteronism (PA) is currently considered the most common cause of secondary and endocrine hypertension. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) as a new detection technique has been gradually applied in the diagnosis of PA. However, the diagnostic value of LC-MS/MS methods for PA has not been systematically clinically validated. The aim was to access the diagnostic accuracy, sensitivity, and specificity of LC-MS/MS methods as screening tools in PA.Materials and methodsA literature search of PubMed, Embase, Medline, Web of Science, Scopus, Science Direct, and Chinese databases was carried out to June 2022 with no language restriction. Data on sensitivity and specificity and other evaluation indicators were extracted and pooled with STATA and Meta-disc software. Heterogeneity was evaluated and meta-regression and subgroup analysis was performed to elucidate sources of heterogeneity.Results12 studies of the diagnostic test were suitable and included in the meta-analysis. Pooled sensitivity, specificity, and diagnostic odds ratio were 0.89 (95% CI: 0.83-0.93), 0.87 (95% CI: 0.82-0.91), and 55 (95% CI: 28-110), respectively. Subgroup analysis assessed the diagnostic power of LC-MS/MS based on the type of detection index. ARR and PAC based on LC-MS/MS methods have the higher diagnostic value compared with other indices, diagnostic odds ratios were 121.65 (95% CI: 36.28-407.98) and 49.85 (95% CI: 24.87-99.93). There was considerable heterogeneity among studies.ConclusionLC-MS/MS methods had higher accuracy and reliability in the diagnosis of primary aldosteronism. LC-MS/MS-based ARR and PAC can be further promoted and applied in the diagnosis of primary aldosteronism.
Pseudocapsule and pseudocapsule-based extracapsular resection in pituitary neuroendocrine tumors
Authors: Wang Xiao Bin , Han Tian Yi , Ma Jian Gong , He Cheng , Xue Li , Zhang Xun , Wu Zhe Bao 
Published: November 2022

Since Costello et al. proposed the concept of pseudocapsule of pituitary neuroendocrine tumors (PitNETs) in 1936, many studies have been published on its occurrence, development process, histopathology, and morphology. Pseudocapsule has been proposed as the anatomical interface between PitNETs and normal pituitary gland, therefore the so-called pseudocapsule-based extracapsular resection (ER) technique was developed as an extracapsular surgery method for PitNETs,which differs from the conventional intracapsular resection (IR). In recent years, ER has also been widely used in patients of different tumor types, sizes, and age groups, because the pseudocapsule can be identified more clearly under the endoscopy. Endoscopic transsphenoidal resection for PitNETs has become the preferred surgical method. We reviewed relevant literatures in the past 10 years, showing that ER could achieve better rate of gross total resection (GTR) and biochemical remission, and reduce tumor recurrence than IR, without increasing postoperative complications. Therefore, the pseudocapsule and ER should be valued by neurosurgeons and actively promoted clinically.