bluuebunny/crossref_metadata_2025_split huggingface dataset:
Project-Based Entrepreneurial Learning (PBEL): A Blended Model for Startup Creations at Higher Education Institutions
Authors: Santoso R. Tri Priyono Budi , Priyanto Sony Heru , Junaedi I Wayan Ruspendi , Santoso Donald Samuel Slamet , Sunaryanto Lasmono Tri 
Published: April 2022

Abstract
This research aims to describe the dynamics of applying project-based entrepreneurial learning (PBEL) in creating startups at higher education institutions. Action research was used for eight participants as the research method by applying the PBEL model in the form of a narrative method. The results revealed that all university students can produce products, starting from prototypes until business products. The PBEL model drives successful startups. For the more effective startups, the PBEL model needs to add network marketing and funding to be applied. Future research is expected to address questions from the results of this study.
Challenges and future directions for Energy, Latency, and Lifetime Improvements in NVMs
Authors: Kargar Saeed , Nawab Faisal 
Published: April 2022

Abstract
Recently, Non-Volatile Memory (NVM) technology has revolutionized the landscape of memory systems. With many advantages, such as non volatility and near zero standby power consumption, these byte-addressable memory technologies are taking the place of DRAMs. Nonetheless, they also present some limitations, such as limited write endurance, which hinders their widespread use in today’s systems. Furthermore, adjusting current data management systems to embrace these new memory technologies and all their potential is proving to be a nontrivial task. Because of this, a substantial amount of research has been done, from both the database community and the storage systems community, that tries to improve various aspects of NVMs to integrate these technologies into the memory hierarchy. In this tutorial we survey state-of-the-art work on deploying NVMs in database and storage systems communities and the ways their limitations are being handled within these communities. In particular, we focus on the challenges that are related to high energy consumption, low write endurance and extending the lifetime of NVM devices.
Lernerfolg in der Schule durch Augmented und Virtual Reality?
Authors: Schweiger Moritz , Wimmer Jeffrey , Chaudhry Maiyra , Alves Siegle Beatriz , Xie Dianchu 
Published: April 2022

Obgleich die Erforschung des pädagogischen Einsatzes von Augmented Reality (AR) und Virtual Reality (VR) an Schulen in den letzten Jahren zugenommen hat, sind systematische Analysen des Lernerfolgs in diesem Bereich spärlich gesät. Die quantitative Synopse wertet 30 aktuelle Studien aus verschiedenen Forschungsbereichen aus. Theoretischer Hintergrund der Studie sind die Modelle des Lernerfolgs nach Puentedura (2010) und Schlicht (2014) sowie das Modell der Medienkompetenz nach Baacke (1996). Die Synopse zeigt, wie AR- und VR-Anwendungen Schüler:innen und Lehrpersonal in diesen schwierigen Zeiten entlasten und zum Lernerfolg beizutragen können. Ihr Einsatz bietet zahlreiche Vorteile, die viele Herausforderungen des heutigen Bildungssystems mildern können. So kann z. B. eine immersive Erfahrung durch VR das Erinnerungsvermögen unterstützen, indem das Gelernte länger behalten und tiefgründiger verstanden wird als ohne den Einsatz von VR-Technologie.
Conjugated Porphyrin Materials for Solar Fuel Generation
Authors: Bai Yang , Sprick Reiner Sebastian 
Published: April 2022

Abstract:
Conjugated materials have emerged as a new class of photocatalysts for solar fuel generation, thus allowing for the Sun’s energy to be converted into a storable fuel that can be used without further emissions at the point of use. Many different building blocks have been used to make conjugated materials that act as photocatalysts allowing for efficient light absorption and tuing of photophysical properties. The porphyrin moiety is a very interesting building block for photocatalysts as the large π-conjugated system allows efficient light absorption. Metalation of porphyrins allows for further tuning of the materials’ properties, thus further expanding the property space that these materials can cover. This allows to design and better control over the properties of the materials, which is discussed in this review together with the state-of-the-art in porphyrin photocatalysts and hybrid systems.
Advances and Applications of Metal-Organic Framework Nanomaterials as Oral Delivery Carriers: A Review
Authors: Liu Yu , Li Li , Qi Zhaorui , Han Shasha , Li Xurui , Liu Bingmi 
Published: April 2022

Abstract:
Oral administration is a commonly used, safe, and patient-compliant method of drug delivery. However, due to the multiple absorption barriers in the gastrointestinal tract (GIT), the oral bioavailability of many drugs is low, resulting in a limited range of applications for oral drug delivery. Nanodrug delivery systems have unique advantages in overcoming the multiple barriers to oral absorption and improving the oral bioavailability of encapsulated drugs. Metal-organic frameworks (MOFs) are composed of metal ions and organic linkers assembled by coordination chemistry. Unlike other nanomaterials, nanoscale metal-organic frameworks (nano-MOFs, NMOFs) are increasingly popular for drug delivery systems (DDSs) due to their tunable pore size and easily modified surfaces. This paper summarizes the literature on MOFs in pharmaceutics included in SCI for the past ten years. Then, the GIT structure and oral drug delivery systems are reviewed, and the advantages, challenges, and solution strategies possessed by oral drug delivery systems are discussed. Importantly, two major classes of MOFs suitable for oral drug delivery systems are summarized, and various representative MOFs as oral drug carriers are evaluated in the context of oral drug delivery systems. Finally, the challenges faced by DDSs in the development of MOFs, such as biostability, biosafety, and toxicity, are examined.
Blood Biomarkers Predict Future Cognitive Decline after Military-Related
Traumatic Brain Injury
Authors: Lippa Sara M. , Gill Jessica , Brickell Tracey A. , Guedes Vivian A. , French Louis M. , Lange Rael T. 
Published: April 2022

Background::
Traumatic brain injury (TBI) has been associated with increased likelihood of late-life dementia; however, the mechanisms driving this relationship are elusive. Blood-based biomarkers may provide insight into these mechanisms and serve as useful prognostic indicators of cognitive recovery or decline following a TBI.

Objective:
The aim of this study was to examine blood biomarkers within one year of TBI and explore their relationship with cognitive decline.

Methods:
Service members and veterans (n=224) without injury (n=77), or with history of bodily injury (n=37), uncomplicated mild TBI (n=55), or more severe TBI (n=55), underwent a blood draw and neuropsychological assessment within one year of their injury as part of a case-control study. A subsample (n=87) completed follow-up cognitive assessment.

Results:
In the more severe TBI group, baseline glial fibrillary acidic protein (p=.008) and ubiquitin C-terminal hydrolase-L1 (p=.026) were associated with processing speed at baseline, and baseline ubiquitin C-terminal hydrolase-L1 predicted change in immediate (R2Δ=.244, p=.005) and delayed memory (R2Δ=.390, p=.003) over time. In the mild TBI group, higher baseline tau predicted greater negative change in perceptual reasoning (R2Δ=.188, p=.033) and executive functioning (R2Δ=.298, p=.007); higher baseline neurofilament light predicted greater negative change in perceptual reasoning (R2Δ=.211, p=.012).

Conclusion:
Baseline ubiquitin C-terminal hydrolase-L1 strongly predicted memory decline in the more severe TBI group, while tau and neurofilament light strongly predicted decline in the mild TBI group. A panel including these biomarkers could be particularly helpful in identifying those at risk for future cognitive decline following TBI.
Peroxisome Proliferator-activated Receptor Gamma Coactivator-1 Alpha:
A Double-edged Sword in Prostate Cancer
Authors: Zheng Kun , Chen Suzhen , Hu Xiaoyong 
Published: April 2022

Abstract:
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-
1α/PPARGC1A) is a pivotal transcriptional coactivator involved in the regulation of mitochondrial
metabolism, including biogenesis and oxidative metabolism. PGC-1α is finely regulated by AMPactivated
protein kinases (AMPKs), the role of which in tumors remains controversial to date. In recent
years, a growing amount of research on PGC-1α and tumor metabolism has emphasized its importance
in a variety of tumors, including prostate cancer (PCA). Compelling evidence has shown that
PGC-1α may play dual roles in promoting and inhibiting tumor development under certain conditions.
Therefore, a better understanding of the critical role of PGC-1α in PCA pathogenesis will provide
new insights into targeting PGC-1α for the treatment of this disease. In this review, we highlight the
procancer and anticancer effects of PGC-1α in PCA and aim to provide a theoretical basis for targeting
AMPK/PGC-1α to inhibit the development of PCA. In addition, our recent findings provide a
candidate drug target and theoretical basis for targeting PGC-1α to regulate lipid metabolism in PCA.
Silencing of FANCI Promotes DNA Damage and Sensitizes Ovarian
Cancer Cells to Carboplatin
Authors: Li Yuqing , Zhang Yanan , Yang Qi , Zhou Xuantong , Guo Yuanyuan , Ding Fang , Liu Zhihua , Luo Aiping 
Published: April 2022

Background:
Ovarian cancer (OVCA) has unique epigenetic alterations and defects in
homologous recombination (HR). Despite initial sensitivity to platinum-based chemotherapy, HR
dysfunctional tumors eventually acquire drug resistance. Fanconi anemia (FA) is characterized by
bone marrow failure (BMF) and a reduced ability to eradicate DNA interstrand cross-links (ICL).
However, the mechanism of chemoresistance mediated by FANCI was unclear in OVCA.

Objective:
We explore to identify whether FANCI was involved in chemoresistance in OVCA.

Methods:
FANCI expression and epigenetic alterations were analyzed, respectively, using TIMER
and cBioPortal. The correlation between FANCI expression and the survival of OVCA patients was
analyzed using Kaplan-Meier Plotter, GSE63885, and TCGA-OVCA dataset. FANCI expression in
OVCA was detected by immunohistochemistry. Cell proliferation, migration, and invasion in FANCI
inhibiting cells were assessed by CCK-8 and Transwell. Apoptosis and DNA damage were examined
by flow cytometry and immunofluorescence. Meanwhile, the activity of caspase 3/7 was detected by
Caspase-Glo® 3/7 kit. In addition, the expression of FANCI, γH2AX, and apoptosis effectors was
examined by Western blot.

Results:
FANCI has copy number variations (CNVs) in OVCA. The high expression of FANCI in
OVCA patients was associated with poor survival. Moreover, FANCI expression was correlated with
the response to chemotherapy in OVCA. FANCI expression in OVCA cells was induced by carboplatin
in a time-dependent manner. Silencing of FANCI had no effect on cell proliferation, but
hindered OVCA cell migration and invasion. Mechanically, knockdown of FANCI enhanced DNA
damage-induced apoptosis through the CHK1/2-P53-P21 pathway.

Conclusion:
FANCI may be a potential therapeutic target for OVCA patients.
The lncRNA Tincr Regulates the Abnormal Differentiation of Intestinal
Epithelial Stem Cells in the Diabetic State Via the miR-668-3p/Klf3 Axis
Authors: Sun Li-Bin , Ding Ai-Ping , Han Yue , Song Ming-Quan , Shan Ti-Dong 
Published: April 2022

Background:
Diabetes mellitus (DM) is among the most common chronic diseases, and diabetic
enteropathy (DE), which is a complication caused by DM, is a serious health condition. Long noncoding
RNAs (lncRNAs) are regulators of DE progression.

Objective:
However, the mechanisms of action of multiple lncRNAs involved in DE remain poorly understood.

Methods:
Reverse transcription-quantitative PCR (RT–qPCR) and in situ hybridization were used to analyze
terminal differentiation-induced lncRNA (Tincr) expression in intestinal epithelial cells (IECs) in the
DM state. Microarray analysis, bioinformatics analysis, and luciferase reporter assays were used to identify
the genes targeted by Tincr. The role of miR-668-3p was then explored by up- and down-regulating its
expression in vitro and in vivo.

Results:
In this study, we observed that the level of lncRNA Tincr was increased in IECs in the DM state.
More importantly, Tincr was associated with abnormal intestinal epithelial stem cell (IESC) differentiation
in DM. Our mechanistic study demonstrated that Tincr is a major marker of Lgr5+ stem cells in DM.
In addition, we investigated whether Tincr directly targets miR-668-3p and whether miR-668-3p targets
Klf3. Our findings showed that Tincr sponged miR-668-3p, which attenuated abnormal IESC differentiation
in DM by regulating Klf3 expression.

Conclusion:
This study presents evidence of an essential role for Tincr in IESC differentiation in DM.
Metal-based Complexes as Potential Anti-cancer Agents
Authors: Banerjee Sabyasachi , Banerjee Subhasis 
Published: April 2022

Abstract:
Metal based therapy is no new in biomedical research. In early days, the biggest limitation was the inequality
among therapeutical and toxicological dosages. Ever since, Barnett Rosenberg discovered cisplatin, a new era has
begun to treat cancer with metal complexes. Platinum complexes such as oxaliplatin, cisplatin, and carboplatin, seem to
be the foundation of metal/s-based components to challenge malignancies. With advancement in the biomolemoecular
mechanism, researchers have started developing non-classical platinum-based complexes, where a different mechanistic
approach of the complexes is observed towards the biomolecular target. Till date, larger numbers of metal/s-based
complexes were synthesized by overhauling the present structures chemically by substituting the ligand or preparing
the whole novel component with improved cytotoxic and safety profiles. Howsoever, due to elevated accentuation
upon the therapeutic importance of metal/s-based components, a couple of those agents are at present in clinical trials
and several other are in anticipating regulatory endorsement to enter the trial. This literature highlights the detailed
heterometallic multinuclear components, primarily focusing on platinum, ruthenium, gold and remarks on possible
stability, synergism, mechanistic studies and structure activity relationships.
Investigation of Flexural Capacity of Normal and Recycled Aggregate Concrete Filled Steel Tubes
Authors: Abdel-Jaber Ma'en , Abdel-Jaber Mutasim , El-Nimri Rola , Katkhuda Hasan 
Published: March 2022

Aims:
This paper aims to compare the experimental and theoretical results of the flexural capacity of normal and recycled aggregate concrete-filled tubes (CFT).
Background: The experimental results of 47 CFT specimens made of natural aggregate (NA), recycled concrete aggregate (RCA), and recycled asphalt pavement (RAP) with steel thicknesses of 2 and 2.4 mm from previous research performed by the authors are adopted.

Methods:
The NA was replaced in the CFT specimens by RCA and RAP with replacement levels of 20%, 40%, 60%, 80%, and 100%. The theoretical study is conducted in this paper based on the provisions of many international codes, available models from the literature, and finite element analysis (FEA) using Abaqus software to obtain the best approach for determining the flexural capacity of CFT.

Results:
The results showed that all code provisions were safe to use as they provided conservative results except for the ACI 318-19. The ANSI/AISC 360-16 and CoPHK provided the best conservative and accurate results.

Conclusion:
Besides, the finite element analysis results were found in good agreement with the experimental results as they provided the most accurate estimation.
The Influence of Cultural and Psychological Factors on Mental Health Status during COVID-19 in Saudi Arabia
Authors: Alqahtani Azizah 
Published: March 2022

Background:The World Health Organization (WHO) announced a public health emergency of international concern (PHEIC) on 30 January 2020 due to the rapid increase in the number of COVID-19 cases outside China. Every pandemic is associated with other problems such as psychological and mental health problems.Methods:The current research investigated the relationship between mental health status and demographic variables and the psychological impact of COVID-19. Furthermore, this study explored the relationship between collectivism and low infection rates. The sample included 1700 adults aged 18 years and older. The questionnaire started with demographic questions followed by the Impact of Event Scale-Revised (IES-R), a scale that was applied to the COVID-19 outbreak, and the Depression, Anxiety and Stress Scale (DASS-21).Results:Findings indicated that depression, anxiety, and stress were associated with the psychological impact of COVID-19. In addition, students experienced a higher level of psychological impact of COVID-19 than other occupational groups. Finally, cultural collectivism was associated with a lower COVID-19 infection rate.Conclusion:It is recommended based on the findings of this paper that the mental health of university students should be observed and assessed during epidemics. Training regarding mental health should be provided to university faculty and staff.
Ebselen’s Potential to Inhibit Planktonic and Biofilm Growth of Neisseria
mucosa
Authors: Shaikh Shaukat A. , Priyadarsini Indira K. , Vavilala Sirisha L. 
Published: April 2022

Background:
Antibiotic resistance of various bacterial communities remains a global burden
in the healthcare industry. Biofilm formation is one of the resistance mechanisms acquired by bacterial
communities in order to reverse the action of antibiotics. There is an urgent need for the discovery
of novel antimicrobials and novel approaches to tackle this problem. However, it is very expensive
and challenging to develop new antibiotics. Drug repurposing is an efficient strategy which reduces
time and cost associated with drug discovery.

Objective:
In the current study, anti-microbial and antibiofilm potential of an organoselenium clinical
molecule Ebselen against Neisseria mucosa has been elucidated.

Methods:
Ebselen Antibacterial studies include Minimum Inhibitory Concentration (MIC), growthkill,
Colony Forming Unit (CFU) assays and intracellular Reactive Oxygen Species (ROS) accumulation
studies. Antibiofilm studies included inhibition, eradication and cell surface hydrophobicity assays,
quantification of Extracellular Polymeric Substance (EPS) and eDNA and for anti-quorum sensing
activity, protease and urease enzyme activities were elucidated.

Results:
Ebselen showed efficient bactericidal activity as indicated by its low MIC values, bacterial
growth inhibition over time and its ability to prevent clonal propagation in this bacterium. Increased
accumulation of ROS in Ebselen treated cells indicates radical mediated induction of bacterial death.
Interestingly, Ebselen inhibited and distorted matured biofilms by degrading the eDNA component of
the EPS layer. Ebselen also attenuated quorum-sensing pathway as indicated by decreased urease and
protease enzyme activities.

Conclusion:
Taken together, these results paved the way to repurpose Ebselen as a potential drug target
to curb Neisseria mucosa infections.
Online Peer Support for People With Parkinson Disease: Narrative Synthesis Systematic Review
Authors: Gerritzen Esther Vera , Lee Abigail Rebecca , McDermott Orii , Coulson Neil , Orrell Martin 
Published: March 2022

Background
Parkinson disease (PD) significantly impacts the lives of people with the diagnosis and their families. In addition to the physical symptoms, living with PD also has an emotional impact. This can result in withdrawal from social roles, increasing the risk for social isolation and loneliness. Peer support is a way to stay socially connected, share experiences, and learn new coping skills. Peer support can be provided both in person and on the internet. Some of the advantages of online peer support are that it overcomes geographical barriers and provides a form of anonymity; moreover, support can be readily available when needed. However, the psychosocial impact of PD is still underresearched, and there is no systematic synthesis of online peer support for people with PD.

Objective
This review aims to explore the benefits and challenges of online peer support and identify successful elements of online peer support for people with PD.

Methods
The method selected for this systematic review is narrative synthesis. A total of 6 databases were systematically searched in April 2020 for articles published between 1989 and 2020. The quality of the included studies was assessed using the Critical Appraisal Skills Programme qualitative research checklist and the Downs and Black quality checklist.

Results
A total of 10,987 unique articles were identified through a systematic database search. Of these 10,987 articles, 8 (0.07%) were included in this review. Of the 8 studies, 5 (63%) were of good or high quality, 2 (25%) were of medium or fair quality, and 1 (13%) study was of poor quality. Web-based platforms included discussion forums, a web-based virtual world, and Facebook groups. Most papers reported on text-based communication. The included studies reported on sharing social support and personal experiences. Successful elements included increasing similarity between members and offering the opportunity to directly ask questions to a physician. Challenges included members leaving without a warning and PD symptoms hindering the use of technology.

Conclusions
Peer support can improve social support and help people with PD in living meaningful and satisfying lives. Peer support is unique and cannot be replaced by family members, friends, or health care professionals. Online peer support can be a solution for those who do not have access to an in-person support group or whose PD symptoms restrict them from travelling. However, research on the personal experiences of those who engage in online peer support and potential barriers in accessing it remains limited. Future research could use qualitative methods to explore these fields further.