bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Difference and Significance of Parietal Pleura Invasion and Rib Invasion in Pathological T Classification With Non-Small Cell Lung Cancer
Authors: Wu Lei-Lei , Li Chong-Wu , Li Kun , Qiu Li-Hong , Xu Shu-Quan , Lin Wei-Kang , Ma Guo-Wei , Li Zhi-Xin , Xie Dong 
Published: April 2022

ObjectiveThis study was to explore the difference and significance of parietal pleura invasion and rib invasion in pathological T classification with non-small cell lung cancer.MethodsA total of 8681 patients after lung resection were selected to perform analyses. Multivariable Cox analysis was used to identify the mortality differences in patients between parietal pleura invasion and rib invasion. Eligible patients with chest wall invasion were re-categorized according to the prognosis. Cancer-specific survival curves for different pathological T (pT) classifications were presented.ResultsThere were 466 patients considered parietal pleura invasion, and 237 patients served as rib invasion. Cases with rib invasion had poorer survival than those with the invasion of parietal pleura (adjusted hazard ratio [HR]= 1.627, P =0.004). In the cohort for parietal pleura invasion, patients with tumor size ≤5cm reached more satisfactory survival outcomes than patients with tumor size &gt;5cm (unadjusted HR =1.598, P =0.006). However, there was no predictive difference in the cohort of rib invasion. The results of the multivariable analysis revealed that the mortality with parietal pleura invasion plus tumor size ≤5cm were similar to patients with classification pT3 (P =0.761), and patients for parietal pleura invasion plus tumor size &gt;5cm and pT4 had no stratified survival outcome (P =0.809). Patients identified as rib invasion had a poorer prognosis than patients for pT4 (P =0.037).ConclusionsRib invasion has a poorer prognosis than pT4. Patients with parietal pleura invasion and tumor size with 5.1-7.0cm could be appropriately up-classified from pT3 to pT4.
Ionic Liquid (EmimAc)-Water Mixture Confined in Nanoporous Glass Matrices Studied With High-Resolution Neutron Spectroscopy
Authors: Frielinghaus H. , Fomina M. , Hayward D. , Dubey P. S. , Jaksch S. , Falus P. , Fouquet P. , Fruhner L. , Holderer O. 
Published: April 2022

We report on the structure and diffusion behaviour of the various constituent molecules in ionic liquid (IL) mixtures under confinement in nanoporous glasses. X-Ray diffraction measurements indicate that the ions adopt a lamellar arrangement under confinement. Furthermore, using selective deuteration in combination with high resolution neutron spectroscopy reveals how the dynamics and the activation energy of the IL is affected by different confinement conditions (pore sizes 50 Å and 135 Å) and different temperatures (265 and 318 K). With different deuteration schemes we could separate the different motions of acetate and water. The confinement leads to distortions of the domains, which gives more room for diffusion. In the smaller pores, the stronger distortion gives even more room such that the hydrogen bonds between acetate and water seem to be even stronger than in bulk and weaker confinement. The results are discussed in the context of previous measurements on dry samples.
Aging of the Peritoneal Dialysis Membrane
Authors: Krediet Raymond T. 
Published: April 2022

Long-term peritoneal dialysis as currently performed, causes structural and functional alterations of the peritoneal dialysis membrane. This decay is brought about by the continuous exposure to commercially available glucose-based dialysis solutions. This review summarizes our knowledge on the peritoneum in the initial phase of PD, during the first 2 years and the alterations in function and morphology in long-term PD patients. The pseudohypoxia hypothesis is discussed and how this glucose-induced condition can be used to explain all peritoneal alterations in long-term PD patients. Special attention is paid to the upregulation of hypoxia inducing factor-1 and the subsequent stimulation of the genes coding for glucose transporter-1 (GLUT-1) and the growth factors transforming growth factor-β (TGFβ), vascular endothelial growth factor (VEGF), plasminogen growth factor activator inhibitor-1 (PAI-1) and connective tissue growth factor (CTGF). It is argued that increased pseudohypoxia-induced expression of GLUT-1 in interstitial fibroblasts is the key factor in a vicious circle that augments ultrafiltration failure. The practical use of the protein transcripts of the upregulated growth factors in peritoneal dialysis effluent is considered. The available and developing options for prevention and treatment are examined. It is concluded that low glucose degradation products/neutral pH, bicarbonate buffered solutions with a combination of various osmotic agents all in low concentration, are currently the best achievable options, while other accompanying measures like the use of RAAS inhibitors and tamoxifen may be valuable. Emerging developments include the addition of alanyl glutamine to the dialysis solution and perhaps the use of nicotinamide mononucleotide, available as nutritional supplement.
Movement Synchrony Over Time: What Is in the Trajectory of Dyadic Interactions in Workplace Coaching?
Authors: Erdös Tünde , Jansen Paul 
Published: April 2022

BackgroundCoaching is increasingly viewed as a dyadic exchange of verbal and non-verbal interactions driving clients' progress. Yet, little is known about how the trajectory of dyadic interactions plays out in workplace coaching.MethodThis paper provides a multiple-step exploratory investigation of movement synchrony (MS) of dyads in workplace coaching. We analyzed a publicly available dataset of 173 video-taped dyads. Specifically, we averaged MS per session/dyad to explore the temporal patterns of MS across (a) the cluster of dyads that completed 10 sessions, and (b) a set of 173 dyadic interactions with a varied number of sessions. Additionally, we linked that pattern to several demographic predictors. The results indicate a differential downward trend of MS.ResultsDemographic factors do not predict best fitting MS curve types, and only client age and coach experience show a small but significant correlation.DiscussionWe provide contextualized interpretations of these findings and propose conceptual considerations and recommendations for future coaching process research and practice.
Self-Reported Maternal Parenting Stress From 9 m Is Longitudinally Associated With Child ADHD Symptoms at Age 12: Findings From a Population-Based Birth Cohort Study
Authors: Endo Kaori , Stanyon Daniel , Yamasaki Syudo , Nakanishi Miharu , Niimura Junko , Kanata Sho , Fujikawa Shinya , Morimoto Yuko , Hosozawa Mariko , Baba Kaori , Oikawa Nao , Nakajima Naomi , Suzuki Kazuhiro , Miyashita Mitsuhiro , Ando Shuntaro , Hiraiwa-Hasegawa Mariko , Kasai Kiyoto , Nishida Atsushi 
Published: April 2022

BackgroundAttention-deficit/hyperactivity disorder (ADHD) develops in early childhood and carries lifelong impact, but early identification and intervention ensure optimal clinical outcomes. Prolonged or excessive parenting stress may be a response to infant behavioral differences antecedent to developmental disorders such as ADHD, and therefore represents a potentially valuable inclusion in routine early-life assessment. To investigate the feasibility of using routinely-collected self-reported maternal parenting stress as a risk marker for child ADHD, this study investigated the longitudinal association between maternal parenting stress from 1 to 36 months after childbirth and child ADHD in early adolescence.MethodsThe sample comprised 2,638 children (1,253 girls) from the Tokyo Teen Cohort population-based birth cohort study. Mothers recorded parenting stress five times from 1 to 36 months following childbirth in the Maternal and Child Health Handbook, a tool used for routine early-life assessment in Japan. Nine years later, mothers evaluated their child's ADHD symptoms at 12 y using the hyperactivity/inattention subscale from the Strength and Difficulties Questionnaire.ResultsApproximately 7.5% of parents reported that they had parenting stress at 36 m after childbirth. 6.2% of children were evaluated as above the cut-off for ADHD symptoms at 12 y. Parenting stress at 1 and 3–4 m was not associated with child ADHD symptoms at 12 y. However, child ADHD symptoms at 12 y was significantly associated with parenting stress at 9–10 m (unadjusted OR = 1.42, p =.047, 95% CI [1.00, 2/00]), 18 m (unadjusted OR = 1.57, p =.007, 95% CI [1.13, 2.19]) and 36 m (unadjusted OR = 1.67, p =.002, 95% CI [1.20, 2.31]). These associations remained after adjustment for child's sex, age in months and family income.ConclusionsWe identified associations between parenting stress at 9–10, 18 and 36 m after childbirth and child ADHD symptoms at 12 years old. Self-reported parenting stress data may have utility as an early indicator for ADHD risk. Participation in early-life health checks, assessment of parenting stress, and tailoring support to family needs should be promoted for early identification and intervention for ADHD.
Research Hotspots and Trends in Music Therapy Intervention for Patients With Dementia: A Bibliometrics and Visual Analysis of Papers Published From 2010 to 2021
Authors: Yin Shao , Zhu Fengya , Li Zhao , Che Deya , Li Liuying , Zhang Lu , Zhong Yue , Luo Biao , Wu Xiaohan 
Published: April 2022

BackgroundAs a serious public health problem, dementia has placed a heavy burden on society and families. Evidence suggests that the use of music therapy as a non-pharmacological intervention has certain advantages with respect to reducing the behavioral and psychological symptoms of dementia (BPSD) and improving the cognition and mental status of dementia patients. However, research trends and hotspots regarding music therapy intervention for dementia analysis have not been systematically studied via bibliometric analysis.MethodsWe searched the Web of Science Core Collection (WoSCC) for texts published between January 1, 2010, and October 31, 2021, and visualized country, institution, journal, keyword co-occurrence, keyword emergence and keyword clustering.ResultsA total of 217 articles from the WoSCC database were analyzed. In this research field, the annual number of publications has generally shown a slowly increasing trend, and the United States has the most publications and the most frequent cooperation among countries. University College London (UCL) has the most extensive influence among research institutions. Among articles, those published in the JOURNAL OF ALZHEIMER'S DISEASE were the most numerous, with 20 such articles being published, accounting for 9.22% (20/217) of the total. Comprehensive analysis of five clusters via biclustering shows that the research hotspots in this field during the past 11 years have mainly focused on the autobiographical memory, cognitive function, mental state and BPSD of dementia patients.ConclusionThis study conducted a bibliometric and visual analysis of relevant studies concerning music therapy intervention for dementia patients. Psychological problems faced by dementia patients and the topics of quality of life, individualized music therapy, the mental state of caregivers and other related topics may be important research directions in the future. Therefore, the question of how to develop standardized research protocols and identify unified efficacy evaluation indicators should be a focus of and difficulty for future research.
Inhibiting BDNF Signaling Upregulates Hippocampal H3K9me3 in a Manner Dependent On In Vitro Aging and Oxidative Stress
Authors: Ionescu-Tucker Andra , Tong Liqi , Berchtold Nicole C. , Cotman Carl W. 
Published: April 2022

Histone modifications are key contributors to the cognitive decline that occurs in aging and Alzheimer’s disease. Our lab has previously shown that elevated H3K9me3 in aged mice is correlated with synaptic loss, cognitive impairment and a reduction in brain derived neurotrophic factor (BDNF). However, the mechanism of H3K9me3 regulation remains poorly understood. In this study, we investigated the role of age-associated stressors on H3K9me3 regulation and examined if changes in H3K9me3 were age dependent. We used cultured hippocampal neurons at 6, 12, and 21 days in vitro (DIV) to examine the effect of different stressors on H3K9me3 across neuron ages. We found that the oxidative stressor hydrogen peroxide (H2O2) does not induce H3K9me3 in 12 DIV neurons. Inhibiting BDNF signaling via TrkB-Fc elevated H3K9me3 in 12 and 21 DIV neurons compared to 6 DIV neurons. Antioxidant treatment prevented H3K9me3 elevation in 12 DIV neurons treated with TrkB-Fc and H2O2. H2O2 elevated the epigenetic regulator SIRT1 in 6 DIV neurons but did not increase H3K9me3 levels. Our findings demonstrate that inhibiting BDNF signaling elevates hippocampal H3K9me3 in a manner dependent on in vitro age and oxidative stress.
Evaluation of a Large-Scale School Wellness Intervention Through the Consolidated Framework for Implementation Research (CFIR): Implications for Dissemination and Sustainability
Authors: McLoughlin Gabriella M. , Sweeney Rachel , Liechty Laura , Lee Joey A. , Rosenkranz Richard R. , Welk Gregory J. 
Published: April 2022

BackgroundNumerous studies have tested school-based interventions promoting healthy behaviors in youth, but few have integrated dissemination and implementation (D&amp;I) frameworks. Using D&amp;I frameworks can inform if and how an evidence-based intervention is implemented and maintained and provide strategies to address contextual barriers. Such application is necessary to understand how and why interventions are sustained over time. We evaluated a school wellness initiative called SWITCH® (School Wellness Integration Targeting Child Health) to (1) assess implementation outcomes of adoption, fidelity, and penetration, (2) discern implementation determinants through the Consolidated Framework for Implementation Research (CFIR), and (3) examine differences among inexperienced and experienced schools and influential factors to sustainment.MethodsA total of 52 schools from Iowa, United States enrolled in the 2019–2020 iteration of SWITCH (22 inexperienced; 30 experienced). The CFIR guided the adaptation of mixed methods data collection and analysis protocols for school settings. Specific attention was focused on (1) fidelity to core elements; (2) adoption of best practices; and (3) penetration of behavior change practices. Determinants were investigated through in-depth qualitative interviews and readiness surveys with implementation leaders. A systematic process was used to score CFIR domains (between −2 and +2) indicating positive or negative influence. Independent t-tests were conducted to capture differences between samples, followed by a cross-case analysis to compare determinants data. Inductive coding yielded themes related to sustainment of SWITCH beyond formal implementation support.ResultsExperienced schools had higher scores on fidelity/compliance (t = −1.86 p = 0.07) and adoption (t = −2.03 p = 0.04). CFIR determinants of innovation source, culture, relative priority, and leadership engagement were positive implementation determinants, whereas tension for change and networks and communications were negative determinants. Distinguishing factors between experienced and inexperienced schools were Readiness for Implementation and Self-efficacy (experienced significantly higher; p &lt; 0.05). Strategies to enhance sustainability were increasing student awareness/advocacy, keeping it simple, and integrating into school culture.ConclusionsFindings provide specific insights related to SWITCH implementation and sustainability but more generalized insights about the type of support needed to help schools implement and sustain school wellness programming. Tailoring implementation support to both inexperienced and experienced settings will ultimately enhance dissemination and sustainability of evidence-based interventions.
Urban–Rural Disparities in the Lung Cancer Surgical Treatment Pathway: The Paradox of a Rich, Small Region
Authors: Minerva Eleonora Maddalena , Tessitore Adele , Cafarotti Stefano , Patella Miriam 
Published: April 2022

IntroductionRural populations in large countries often receive delayed or less effective diagnosis and treatment for lung cancer. Differences are related to population-based factors such as lower pro capita income or increased risk factors or to differences in access to facilities. Switzerland is a small, rich country with peculiar geographic and urban characteristics.We explored the relationship between lung cancer diagnostic–surgical pathway and urban–rural residency in our region.MethodsWe retrospectively analyzed the medical records of 280 consecutive patients treated for primary non-small cell lung cancer at our institution (2017–2021). This is a regional tertiary center for diagnosis and treatment, and data were extracted from a prospectively collected clinical database. We included anatomical lung resection. Collected variables included patients and surgical characteristics, risk factors, comorbidities, histology and staging, symptoms (vs. incidental diagnosis), general practitioner (GP) involvement, health insurance, and suspected test-treatment interval. The exposure was rurality, defined by the 2009 rural–urban residency classification from the Department of Land.ResultsA total of 150 patients (54%) lived in rural areas. Rural patients had a higher rate of smoking history (93% vs. 82%; p = 0.007). Symptomatic vs. incidental diagnosis did not differ as well as previous cancer rate, insurance, and pathological staging. In rural patients, there was a greater burden of comorbidities (mean Charlson Comorbidity Index Age-Adjusted 5.3 in rural population vs. 4.8 in urban population, p = 0.05), and GP was more involved in the diagnostic pathway (51% vs. 39%, p = 0.04). The interval between the first suspected test and treatment was significantly shorter (56 vs. 66.5 days, p = 0.03). Multiple linear regression with backward elimination was run. These variables statistically predicted the time from the first suspected test and surgical treatment [F(3, 270), p &lt; .05, R2 = 0.24]: rurality (p = 0.04), GP involvement (p = 0.04), and presence of lung cancer-related symptoms (p = 0.02).ConclusionsIn our territory with inhomogeneous population distribution and geographic barriers, residency has an impact on the lung cancer pathway. It seems paradoxical that rural patients had a shorter route. The more constant involvement of GP might explain this finding, having suggested more tests for high-risk patients in the absence of symptoms or follow-ups. This did not change the staging of surgical patients, but it might be essential for the organization of an effective lung cancer screening program.
Hábitos sexuais e de anticoncepção em jovens de uma universidade do Distrito Federal / Sexual and contraceptive habits among young people at a university in the Federal District
Authors: Tavares Isabela Boulhosa , Cardoso Mateus Ricardo , Campos Luciana Teixeira de 
Published: April 2022

Esta pesquisa objetivou conhecer a epidemiologia dos hábitos sexuais e de anticoncepção de jovens de uma universidade do Distrito Federal. Trata-se de um estudo epidemiológico de caráter descritivo, com abordagem quantitativa, sendo um levantamento, entre os anos de 2020 e 2021, com análise de questionários estruturados auto aplicáveis sobre os efeitos do uso de métodos contraceptivos na sexualidade. As variáveis investigadas foram: idade, sexo, escolaridade, uso e conhecimento sobre os contraceptivos, hábitos sexuais, opiniões sobre sexualidade. Os sujeitos da pesquisa foram 252 alunos do Centro Universitário de Brasília (UniCEUB) que assinaram o termo de consentimento livre e esclarecido que já tiveram a sexarca. A pesquisa foi aprovada pelo Comitê de Ética sob nº 4.373.886. Em relação à primeira relação sexual, 56% dos entrevistados revelaram ter sido após os 18 anos e 20% não fez uso de métodos contraceptivos, já dos que tiveram a relação antes dos 18 anos (44%), 28,5% não fizeram uso de tais métodos nesta relação. Dos entrevistados, 69% referiu usar sempre, 21,8% na maioria das vezes, 2% raramente e 7,2% não faz. Assim, 43,3% usam preservativos, 21,8% contraceptivos orais e 19% dupla proteção. Dos que usam preservativos de barreira, apenas 19% fazem uso durante toda a relação sexual. 49,2% dos estudantes acreditam que o uso de métodos de barreira atrapalha no prazer sexual e 26,6% referem que o uso destes prejudicam a naturalidade e espontaneidade do ato. Tratando-se de parceiros fixos, 58,3% não faz uso de métodos que previnem Infecções Sexualmente Transmissíveis, desses, apenas 29,2% interrompem após realização de exames. A maior parte dos entrevistados (79,4%) recebeu orientações sobre saúde sexual e planejamento familiar, sendo que 6,7% obtiveram estas informações apenas após a 1ª relação. Ademais, a maior parte obteve tais orientações pelas escolas (70,2%), 52,9% dos pais e apenas 22,2% de serviços de saúde. A maior parte dos estudantes (96%) concorda que a responsabilidade pelo uso de contraceptivos deve ser das duas pessoas. Dentre os entrevistados, 76,2% tem um plano de vida, desses 2% não fez uso de contraceptivos na primeira relação e, dos que não tem tal plano, 11% não fizeram uso de anticoncepção. Os resultados demonstram que uma proporção alta dos estudantes teve a primeira relação sexual com menos de 18 anos, além da baixa prevalência do uso correto de métodos anticoncepcionais e proteção contra ISTs. Assim, os achados enfatizam a necessidade da orientação sobre saúde sexual e planejamento familiar com objetivo primário prevenir a gravidez indesejada e doenças sexualmente transmissíveis. Deve-se incentivar essa abordagem em instituições de ensino e serviços de saúde, de forma a proteger a saúde e incentivar o planejamento de vida dos estudantes.