bluuebunny/crossref_metadata_2025_split huggingface dataset:
Panorama of intimate partner violence against women in Brazil and its association with self-perception of health: findings from a national representative survey
Authors: Signorelli Marcos , de Souza Felipe Granado , Junior Raimundo V. B. Pinheiro , Valente Juliana , Andreoni Solange , Rezende Leandro F. M. , Sanchez Zila Van Der Meer 
Published: February 2022

Abstract
Objective: This study aimed to describe the prevalence of Intimate Partner Violence (IPV) and its subtypes against adult women in Brazil, as well as their health consequences, and the use of health services resulting from IPV. We also investigated the association of IPV with self-perceived health in victimized women. Methods: Cross-sectional study including 34,334 women aged 18 to 59 years from the 2019 Brazilian National Health Survey. For the analyses, the prevalence of IPV and its types in the last 12 months, health consequences, and use of health services by these women were calculated. Logistic regression models were performed to estimate the association of sociodemographic characteristics and self-perceived health status with IPV. Results: The prevalence of IPV against Brazilian adult women in the last twelve months was 7.6% (95% CI: [7.0; 8.2]). Women aged 18 to 39 years, living with a partner, single or divorced, with complete high school or incomplete higher education and income of up to 1 minimum wage, had higher odds of suffer IPV. As health consequences, approximately 69% of the women who suffered IPV reported psychological consequences. Among those who reported health consequences, 13.9% sought health care, mainly in primary or secondary health care in the Brazilian Public Unified Health System (SUS) (41.9%). Regarding the self-perceived health variables, women who reported eating problems (OR=1.29; 95% CI [1.01; 1.65]), lack of interest/absence of pleasure (OR=1.41; 95% CI [1.11; 1.79]), depressive feeling (OR=1.39; 95% CI [1.03; 1.88]), feeling of failure (OR=1.75; 95% CI [1.36; 2.24]) and suicidal thinking (OR=1.73; 95% CI [1.25; 2.41]) had greater odds of reporting IPV, when compared to those who did not report these same perceptions. Conclusion: The results show that younger, divorced or single, low-income women with eating and mental health problems were more likely to suffer IPV. IPV often led to health problems, and many abused women sought support from public health services due to IPV. Therefore, health professionals must be trained to identify and care for these women, thereby acting as allies in preventing and reducing violence against women in Brazil.
Quercetin relieves ferroptosis and M1 polarization in neutrophilic asthmatic mouse model
Authors: Wang Yang , Wan Rongjun , Peng Wang , Li Yuanyuan , Zhao Xincheng , Bai Wenxuan , Chen Qiong , Hu Chengping 
Published: February 2022

Abstract
Background
Ferroptosis is a kind of regulated cell death, widely involved in lung diseases, including asthma. Macrophages are vital regulators in ferroptosis, and ferroptosis could promote M1 macrophage polarization. Quercetin (QCT), a kind of natural dietary flavonoid, could be an alternative treatment for ferroptosis and asthma. However, whether QCT could reduce ferroptosis in neutrophilic asthma (NA) remains to be described.
Materials:
A NA model was conducted to investigate the therapeutic function of QCT and ferrostatin-1 (Fer-1, ferroptosis inhibitor). Macrophage cell line, RAW 264.7 cell, was stimulated with LPS and QCT, Fer-1. The cell viability, inflammatory cytokines, were measured in all groups. The mitochondria morphological changes, malonaldehyde (MDA) levels and ferroptosis pathway proteins were also detected.
Results
In our study, QCT restored mitochondrial morphologic changes of lung tissues by reducing MDA level and increasing ferroptosis anti-oxidant markers proteins level (SLC7A11 and GPX4) in NA mouse model. In vitro experiment, QCT reduced macrophage ferroptosis, through upregulating cell viability and proteins level (SLC7A11 and GPX4), and reducing MDA level. Furthermore, we investigated that Fer-1 could inhibit M1 polarization, suggesting ferroptosis could promote M1 polarization. And QCT could inhibit M1 macrophage polarization in vitro and in vivo, just as Fer-1 did.
Conclusion
Our study first indicated that ferroptosis occurred in NA, and first demonstrated QCT could be a promising ferroptosis inhibitor in NA treatment. Besides, ferroptosis occurred in M1 macrophages phenotypes, and QCT could inhibit the M1 macrophage polarization, as Fer-1 did.
Agricultural Drought Disaster Risk Assessment in Shandong, China
Authors: Yang Wentong , Zhang Liyuan , Liang Chunlei 
Published: February 2022

Abstract
Shandong Province, the main grain-producing area in China, has ranked first in China in terms of total agricultural output value for many years. However, droughts with high frequency and long duration have been hindering local agricultural production. This paper aims to assess the risk of drought disaster in Shandong Province. Based on the natural disaster system theory, an agricultural drought disaster risk assessment model is developed. This model is applied to assess the agricultural drought hazard, exposure, vulnerability, emergency response and recovery capability, and comprehensive agricultural drought disaster risk year by year from 2012 to 2019. The results show that: (1) There is an aridity trend in Shandong Province. The interannual variation of drought hazard is obvious, and the areas with high drought hazard levels are largely located in the eastern part. (2) Agricultural exposure and vulnerability are mainly concentrated in the western part of Shandong Province. With the decrease in the proportion of the rural population, there is a slight downward trend of agricultural exposure. (3) The interannual variation of emergency response and recovery capability in Shandong Province is relatively stable. Agricultural insurance premiums in all regions have a clear upward trend, which is helpful for disaster risk reduction. (4) Rizhao has been in a high-risk area, moreover, Binzhou, Dezhou, and Liaocheng have gradually become high-risk areas in recent years. The interannual variation characteristics and spatial zoning of agricultural drought risk are explored, it is instructive for risk decision-makers to better develop drought response measures and improve drought resilience.
Anesthesiology Trainees Performing Flexible Scope Intubation in Patients in the Left Lateral Position and the Supine Position: A Prospective Randomized Trial
Authors: Charoenkoop Poonyanuch , Luetrakool Punchika , Puttapornpattana Tipanan , Sangdee Nakkanan 
Published: February 2022

Abstract
Background: Flexible scope intubation is an important airway management skill that requires hands-on training in a real airway. We compared flexible scope intubation by trainees between patients in the left lateral and supine positions.Methods: Forty patients aged 20 to 80 years with American Society of Anesthesiologists physical status I to III were scheduled for elective surgery under general endotracheal anesthesia in Ramathibodi Hospital from February 2020 to June 2020. Patients were randomly assigned to be intubated in one of two positions: supine (group S) or left lateral (group L). Trainees performed flexible scope intubation in sedated patients under the supervision of an attending anesthesiologist. Intubation success, time to successful intubation, number of attempts, airway adjustment maneuvers, and hemodynamic changes were compared between groups.Results: Patient characteristics did not differ between groups except for Mallampati airway classification. The rate of successful intubation on the first attempt and intubation time did not significantly differ between groups. The proportion of patients who required a jaw thrust during intubation was significantly lower in group L (10.5% vs. 85%; P <0.01). Blood pressure and oxygen saturation declined in both groups after intubation. Relative risk of desaturation in the left lateral position compared with the supine position was 0.44 (0.1649–1.1978). Conclusion: The rate of successful flexible scope intubation on the first attempt and intubation time did not differ between both groups. The proportion of patients who required a jaw thrust maneuver was significantly lower in patients in the left lateral position. Trial registration: https://www.thaiclinicaltrials.org/ (TCTR20200208001) on 08/02/2020.
Prediction Modeling of Mental Well-Being Using Health Behavior Data of College Students
Authors: Rahman Hanif Abdul , Kwicklis Madeline , Ottom Mohammad , Amornsriwatanakul Areekul , Abdul-Mumin Khadizah H. , Rosenberg Michael , Dinov Ivo D. 
Published: February 2022

Abstract
Background: Since the onset of the COVID-19 pandemic in early 2020, the importance of timely and effective assessment of mental well-being has increased dramatically. Due to heightened risks for developing mental illness, this trend is likely to continue during the post-pandemic period. Machine learning (ML) algorithms and artificial intelligence (AI) techniques can be harnessed for early detection, prognostication and prediction of negative psychological well-being states.Objective: Studies using machine learning classification of mental well-being are scarce in Asian populations. This investigation aims to develop reliable machine learning classifiers based on health behavior indicators applicable to university students in South-East Asia.Methods: Using data from a large, multi-site cross-sectional survey, this research work models mental well-being and reports on the performance of various machine learning algorithms, such as generalized linear models, k-nearest neighbor, naïve-Bayes, neural networks, random forest, recursive partitioning, bagging, and boosting. Prediction models were evaluated using various metrics such as accuracy, error rate, kappa, sensitivity, specificity, Area Under the recursive operating characteristic Curve (AUC), and Gini Index.Results: Random forest and adaptive boosting algorithms achieved the highest accuracy of identifying negative mental well-being traits. The top five most salient features associated with predicting poor mental well-being include body mass index, number of sports activities per week, grade point average (GPA), sedentary hours, and age.Conclusions: Based on the reported results, several specific recommendations and suggested future work are discussed. These findings may be useful to provide cost-effective support and modernize mental well-being assessment and monitoring at the individual and university level.
The Rationale For Treating Uveal Melanoma With Adjuvant Melatonin: A Review of The Literature
Authors: Hagström Anna , Omar Ruba Kal , Williams Pete A. , Stålhammar Gustav 
Published: February 2022

Abstract
Background: Uveal melanoma is a rare form of cancer with high mortality. The incidence of metastases is attributed to early seeding of micrometastases from the eye to distant organs, primarily the liver. Once these seeded clusters of dormant tumor cells grow into larger radiologically detectable macrometastases, median patient survival is less than a year. Melatonin is an important hormone for synchronizing circadian rhythms. It is also involved in other aspects of human physiology and may offer therapeutic benefits for a variety of diseases including cancer. Methods: Articles involving the physiological effects of melatonin, pharmacokinetics, and previous use in cancer studies were acquired using a comprehensive literature search in the Medline (PubMed) and Web of Science databases. In total, 147 publications were selected and included in the review.Results: Melatonin has been observed to suppress the growth of cancer cells, inhibit metastatic spread, enhance immune system functions, and act as an anti-inflammatory in both in vitro and in vivo models. Melatonin may also enhance the efficacy of cancer treatments such as immuno- and chemotherapy. Numerous studies have shown promising results for oral melatonin supplementation in patients with other forms of cancer including cutaneous malignant melanoma. Cell line and animal studies support a hypothesis in which similar benefits may exist for uveal melanoma. Conclusions: Given its low cost, good safety profile, and limited side effects, there may be potential for the use of melatonin as an oncostatic treatment. Future avenues of research could include clinical trials to evaluate the effect of melatonin in prevention of macrometastases of uveal melanoma.
MicrobiotaProcess: A comprehensive R package for managing and analyzing microbiome and other ecological data within the tidy framework
Authors: Xu Shuangbin , Li Zhan , Tang Wenli , Dai Zehan , Zhou Lang , Feng Tingze , Chen Meijun , Liu Shanshan , Fu Xiaocong , Wu Tianzhi , Hu Erqiang , Yu Guangchuang 
Published: February 2022

Abstract
The data output from microbiome research is growing at an accelerating rate, yet mining the data quickly and efficiently remains difficult. There is still a lack of effective data structure to represent and manage data, as well as flexible and composable analysis methods. In response to these two issues, we designed and developed the MicrobiotaProcess package. It provides a comprehensive data structure, MPSE, to better integrate the primary and intermediate data, which improves the integration and exploration of the downstream data. Around this data structure, the downstream analysis tasks are decomposed and a set of functions are designed under the tidy framework. These functions independently perform simple tasks and can be combined to perform complex tasks. This gives users the ability to explore data, conduct personalized analysis and develop analysis workflows. Moreover, MicrobiotaProcess can interoperate with other packages in the R community, which further expands its analytical capabilities. This article demonstrates the MicrobiotaProcess for analyzing microbiome data as well as other ecological data through several examples. It connects upstream data, provides flexible downstream analysis components, and provides visualization methods to assist in presenting and interpreting results.
A Fluorescent Photoimmunoconjugate For Imaging of Cholesteatoma
Authors: Early Samuel , Saad M. Ahsan , Mallidi Srivalleesha , Mansour Amer , Seist Richard , Hasan Tayyaba , Stankovic Konstantina M. 
Published: February 2022

Abstract
Cholesteatoma is a potentially serious complication of chronic ear infections and requires surgical intervention for definitive management. Long-term complications include a frequent need for repeat surgical intervention for disease recurrence, and techniques to improve efficacy of single-stage surgery are an important area of continued research. This study investigates a novel application of the photosensitizer immune conjugate (PIC) cetuximab-benzoporphyrin derivative (Cet-BPD) for in vitro localization of human cholesteatoma tissue, coupled with an in vivo safety study for middle ear application of Cet-BPD in a murine model. In fresh human cholesteatoma tissues, Cet-BPD demonstrates selective localization to the hyperplastic squamous cell tissue associated with cholesteatoma, without localizing to other tissues such as middle ear mucosa. Applied to the murine middle ear, Cet-BPD does not demonstrate any deleterious effect on murine hearing when assessed by any of auditory brainstem response (ABR) thresholds, distortion product otoacoustic emission thresholds, or ABR wave I amplitudes. These findings demonstrate the technical promise and encouraging safety profile for the use of PICs for intraoperative localization and treatment of cholesteatoma.
A Model for Network-Based Identification and Pharmacological Targeting of Aberrant, Replication-Permissive Transcriptional Programs Induced by Viral Infection
Authors: Laise Pasquale , Stanifer Megan , Bosker Gideon , Sun Xiaoyun , Triana Sergio , Doldan Patricio , Manna Federico La , De Menna Marta , Realubit Ronald , Pampou Sergey , Karan Charles , Alexandrov Theodore , Julio Marianna Kruithof-de , Califano Andrea , Boulant Steeve , Alvarez Mariano 
Published: February 2022

Abstract
Precise characterization and targeting of host cell transcriptional machinery hijacked by viral infection remains challenging. Here, we show that SARS-CoV-2 hijacks the host cell transcriptional machinery to induce a phenotypic state amenable to its replication. Specifically, analysis of Master Regulator (MR) proteins representing mechanistic determinants of the gene expression signature induced by SARS-CoV-2 in infected cells revealed coordinated inactivation of MRs enriched in physical interactions with SARS-CoV-2 proteins, suggesting their mechanistic role in maintaining a host cell state refractory to virus replication. To test their functional relevance, we measured SARS-CoV-2 replication in epithelial cells treated with drugs predicted to activate the entire repertoire of repressed MRs, based on their experimentally elucidated, context-specific mechanism of action. Overall, >80% of drugs predicted to be effective by this methodology induced significant reduction of SARS-CoV-2 replication, without affecting cell viability. This model for host-directed pharmacological therapy is fully generalizable and can be deployed to identify drugs targeting host cell-based MR signatures induced by virtually any pathogen.
MR Imaging Phenotypes and Features Associated with Pathogenic Mutation to Predict Recurrence or Metastasis in Breast Cancer
Authors: lu hong , shao zhenzhen , yu jinpu , cheng yanan , ma wenjuan , liu peifang 
Published: February 2022

Abstract
Objectives: To develop a multiple-feature model using clinico-pathological and radiologic characteristics adding pathogenic mutations associated signs for predicting recurrence or metastasis in breast cancers at high familial risk women.Methods: Genetic testing for breast-related gene mutations was performed in 54 patients with breast cancers. Breast MRI findings were retrospectively evaluated in 64 tumors of 54 patients. The relationship between pathogenic mutation and clinico-pathological and radiologic features was examined, and disease recurrence or metastasis was estimated. Multiple logistic regression analyses were performed to identify independent factors of pathogenic mutation and disease recurrence or metastasis. Based on the above significant factors, a multivariate logistic regression was adopted to establish two models for predicting disease recurrence or metastasis in breast cancer by using R software.Results: On the 64 breast cancers, the patients on 17 cancers have pathogenic mutation，and no pathogenic mutation on 47 cancers. The clinico-pathogenic and radiologic features associated with pathogenic mutation included six signs: biologic features (p=0.000), nuclear grade (p=0.045), breast density (p=0.005), MRI lesion type (p=0.000), internal enhancement pattern (p=0.004), and spiculated margin (p=0.049). Necrosis within the tumors was only feature associated with increased disease recurrence or metastasis (p=0.006). The modelⅠincluding clinico-pathologic and radiologic factors showed good discrimination in predicting disease recurrence or metastasis. The comprehensive modelⅡ including modelⅠcombined pathogenic mutations significantly associated signs is more effective.Conclusions: The multiple-feature model in addition to pathogenic mutations associated parameters can more effective in predicting disease recurrence or metastasis.
Epstein-Barr virus-driven B cell lymphoma mediated by a unique LMP1-TRAF6 complex
Authors: Giehler Fabian , Ostertag Michael , Sommermann Thomas , Weidl Daniel , Sterz Kai , Kutz Helmut , Feller Stephan , Geerlof Arie , Biesinger Brigitte , Popowicz Grzegorz , Kirchmair Johannes , Kieser Arnd 
Published: February 2022

Abstract
The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) drives viral B cell transformation and oncogenesis. LMP1's transforming activity depends on its cytoplasmic C-terminal activation region 2 (CTAR2), which induces NF-κB and JNK by engaging TNF receptor-associated factor 6 (TRAF6). The mechanism of TRAF6 interaction with LMP1 and its critical role for LMP1 signaling has remained elusive. Here we demonstrate that TRAF6 interacts directly with a novel viral TRAF6 binding motif within CTAR2. Structural modeling supported by NMR and functional studies provides insight into the molecular architecture of the LMP1-TRAF6 complex and reveals substantial differences to CD40-TRAF6 interaction. The direct recruitment of TRAF6 to LMP1 is essential for NF-κB activation and survival of LMP1-driven B cell lymphoma. Disruption of the LMP1-TRAF6 complex by inhibitory peptides interferes with proliferation of EBV-transformed B cells. We identify LMP1-TRAF6 as critical virus-host interface and validate this interaction as novel therapeutic target against EBV.
Preparation of Chitosan-Carbon Nanotubes Decorated with ZnO@laccase:
Application in the Removal of Bisphenol A from Aqueous Solution
Authors: Ahari Shabnam Maali , Tabatabaei Zohreh Ghazi 
Published: February 2022

Abstract
Bioremediation with immobilized enzymes has been established as the leading method for restoring contaminated ecosystems using biological tools on a global scale. The purpose of this work is to immobilize the laccase enzyme to enhance the biocatalyst′s ability to remove bisphenol A. Initially, the nanocatalyst was prepared by immobilizing laccase on chitosan using carbon nanotubes decorated with zinc oxide. Subseuentally, Fourier Transformed Infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Field Emission Scanning, and Transmission Electron Microscopy (FESEM and TEM respectively), Energy-dispersive X-ray spectroscopy (EDX), and dot mapping were employed to characterize the prepared nanocomposites. Furthermore, laccase activity, immobilization yield (%), thermal and storage stability and reusability of laccase immobilized on chitosan-coated CNTs/ZnO nanocomposites were measured. Finally, the performance CS-CNTs/ZnO@laccase nano biocatalyst in different operational conditions (initial concentration of bisphenol A, amount of nano biocatalyst, pH, and irradiation time) on the photodegradation process of bisphenol A was investigated and optimized using the response surface methodology (RSM)-central composite design (CCD) model. The RSM design and experiments demonstrated that 94.51% of BPA was removed under optimal conditions (initial BPA concentration of 100 mg L-1, nano biocatalyst amount of 1 g L−1, pH=9, and 40 min of contact exposure). Laccase was a critical factor in this process, and after five recycles, immobilized laccase retained 61% of its original activity, indicating that the nano biocatalyst can be used in purification processes as a durable and robust catalyst.
Direct Observation of Spallation Bombs During The 2021 La Palma Eruption, Canary Islands, Spain
Authors: M.D James , Geiger Harri , Troll Valentin R. , Perez-Torrado Francisco J. , Aulinas Meritxell , Gisbert Guillem , Carracedo Juan Carlos 
Published: February 2022

Abstract
Expulsion of incandescent pyroclasts of >64 mm from active volcanoes are known as ‘volcanic bombs’1-3, which can pose significant hazards to life and manmade structures. Most volcanic bombs are considered to fall ballistically, enabling the prediction of a volcanic hazard radius4,5. Here we describe a bomb type that was ejected ballistically, but subsequently travelled downslope a steep volcanic flank, posing an important but hitherto unrecognized impact and fire hazard. The volcanic bombs were observed to fall from the summit of the newly formed La Palma cone in late October 2021 and fell on a soft tephra substrate, travelling downhill for over a kilometer in some instances. The bombs spalled incandescent lava fragments en route, creating a significant fire hazard far beyond the range of ballistic transport. Spallation bomb hazards ought to be considered in volcanic risk assessment, necessitating an increase of hazard radius exceeding a factor of two on steep-sided volcanoes with ballistic bomb activity.