bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary quality of school meals and packed lunches: a national study of primary and secondary schoolchildren in the UK
Authors: Haney Erin , Parnham Jennie C , Chang Kiara , Laverty Anthony A , von Hinke Stephanie , Pearson-Stuttard Jonathan , White Martin , Millett Christopher , Vamos Eszter P 
Published: June 2022

AbstractObjective:School lunches represent a key opportunity to improve diets and health of schoolchildren. No recent nationally representative studies have examined the nutritional differences between school meals and packed lunches in the UK. This study aimed to characterise and compare the nutritional quality of school meals and packed lunches among primary and secondary school-age children.Design:A pooled cross-sectional analysis of the UK’s National Diet and Nutrition Survey (2008–2017).Setting:United Kingdom.Participants:3001 children (aged 4–16 years) who completed a 3/4-d food diary which recorded meal type (school meal/packed lunch). Multivariable logistic regression models assessed associations of meeting food and nutrient recommendations by meal type. Analyses were stratified by academic key stages (KS).Results:KS-1 (4–7 years) and 2 (8–11 years) children consuming school meals were more likely to meet minimum recommendations for vegetables, protein-rich foods and fibre, and not exceed maximum recommendations for salt, savoury and sweet snacks compared with pupils consuming packed lunches. However, in KS-3 (12–14 years) and 4 (14–16 years), these effects were reduced. As children aged, the median weight of fruits, vegetables, protein-rich foods and dairy products consumed typically decreased for both school meals and packed lunches, and generally an increasing proportion of school meals contained sweet and savoury snacks.Conclusion:These findings suggest school meals are nutritionally superior to packed lunches but are not yet optimal. Quality declined at higher KS. Actions to improve lunches of primary and secondary schoolchildren across the UK are needed, with attention to KS-3 and 4 in secondary schools.
Differences in energy and nutrient content of menu items served by large chain restaurants in the USA and the UK in 2018
Authors: Huang Yuru , Burgoine Thomas , Theis Dolly RZ , Adams Jean 
Published: June 2022

AbstractObjective:To quantify the sector-wide energy and nutritional differences of both adult and children’s restaurant menu items in the UK and the USA in 2018.Design:Cross-sectional study.Setting:Energy and nutritional information provided on restaurant websites.Participants:Menu items (n 40 902) served by forty-two large UK chains and ninety-six large USA chains.Results:Mean absolute energy, fat and saturated fat values were higher in USA menu items. For example, the mean adjusted per-item differences of adult menu items between the USA and the UK were 45·6 kcal for energy and 3·2 g for fat. Comparable figures for children’s menu items were 43·7 kcal and 4 g. Compared with UK menu items, USA adult menu items also had higher sugar content (3·2 g, 95 % CI (0·5, 6)), and children’s menu items had higher Na content (181·1 mg, 95 % CI (108·4, 253·7)). Overall, 96·8 % of UK and 95·8 % of USA menu items exceeded recommended levels for at least one of Na, fat, saturated fat or sugars.Conclusions:Menu items served by large chain restaurants had higher mean absolute levels of energy, fat and saturated fat in the USA compared with the UK. UK adult menu items were also lower in sugars compared with the USA ones and children’s items lower in Na. As more than 95 % of all items were considered to have high levels of at least one nutrient of public health concern in the USA and the UK, improvements in restaurant menu items are needed in both countries.
Atmospheric entry of sub-millimetre-sized grains into Mars atmosphere: white soft mineral micrometeoroids
Authors: Micca Longo Gaia , Longo Savino 
Published: June 2022

AbstractIn this work, we study the passage through the Martian atmosphere of micrometeorites with a white soft mineral (WSM) composition, which have been proposed as transporters of organic molecules in the solar system. The atmospheric entry model includes the dynamics of the atmospheric entry and the physico-chemical aspects of the thermal decomposition process. The results show that, due to the reduced entry speed, Mars may have been a promising collector of matter in this form. In particular, the chemical decomposition process is much more effective than in the case of the Earth's atmosphere in maintaining a moderate temperature of the micrometeorite during most of the entry process.
The Climate and Ozone Impacts of Black Carbon Emissions From Global Rocket Launches
Authors: Maloney Christopher M , Portmann Robert W , Ross Martin N , Rosenlof Karen H 
Published: June 2022

AbstractAerosol emissions from spaceflight activities play a small but increasing role in the background stratospheric aerosol population. Rockets used by the global launch industry emit black carbon (BC) particles directly into the stratosphere where they accumulate, absorb solar radiation, and warm the surrounding air. We model the chemical and dynamical response of the atmosphere to northern mid‐latitude rocket BC emissions. We initially examine emissions at a rate of 10 Gg per year, which is an order of magnitude larger than current emissions, but consistent with extrapolations of space traffic growth several decades into the future. We also perform runs at 30 and 100 Gg per year in order to better delineate the atmosphere's response to rocket BC emissions. We show that a 10 Gg/yr rocket BC emission increases stratospheric temperatures by as much as 1.5 K in the stratosphere. Changes in global circulation also occur. For example, the annual subtropical jet wind speeds slow down by as much as 5 m/s, while a 10%–20% weakening of the overturning circulation occurs in the northern hemisphere during multiple seasons. Warming temperatures lead to a ozone reduction in the northern hemisphere by as much as 16 DU in some months. The climate response increases in a near linear fashion when looking at larger 30 and 100 Gg emission scenarios. Comparing the amplitude of the atmospheric response using different emission rates provides insight into stratospheric adjustment and feedback mechanisms. Our results show that the stratosphere is sensitive to relatively modest BC injections.
Unraveling Forest Complexity: Resource Use Efficiency, Disturbance, and the Structure‐Function Relationship
Authors: Murphy Bailey A. , May Jacob A. , Butterworth Brian J. , Andresen Christian G. , Desai Ankur R. 
Published: June 2022

AbstractStructurally complex forests optimize resources to assimilate carbon more effectively, leading to higher productivity. Information obtained from Light Detection and Ranging (LiDAR)‐derived canopy structural complexity (CSC) metrics across spatial scales serves as a powerful indicator of ecosystem‐scale functions such as gross primary productivity (GPP). However, our understanding of mechanistic links between forest structure and function, and the impact of disturbance on the relationship, is limited. Here, we paired eddy covariance measurements of carbon and water fluxes from nine forested sites within the 10 × 10 km CHEESEHEAD19 study domain in Northern Wisconsin, USA with drone LiDAR measurements of CSC to establish which CSC metrics were strong drivers of GPP, and tested potential mediators of the relationship. Mechanistic relationships were inspected at five resolutions (0.25, 2, 10, 25, and 50 m) to determine whether relationships persisted with scale. Vertical heterogeneity metrics were the most influential in predicting productivity for forests with a significant degree of heterogeneity in management, forest type, and species composition. CSC metrics included in the structure‐function relationship as well as driver strength was dependent on metric calculation resolution. The relationship was mediated by light use efficiency (LUE) and water use efficiency (WUE), with WUE being a stronger mediator and driver of GPP. These findings allow us to improve representation in ecosystem models of how CSC impacts light and water‐sensitive processes, and ultimately GPP. Improved models enhance our capacity to accurately simulate forest responses to management, furthering our ability to assess climate mitigation strategies.
Mid-infrared III–V semiconductor lasers epitaxially grown on Si substrates
Authors: Tournié Eric , Monge Bartolome Laura , Rio Calvo Marta , Loghmari Zeineb , Díaz-Thomas Daniel A. , Teissier Roland , Baranov Alexei N. , Cerutti Laurent , Rodriguez Jean-Baptiste 
Published: June 2022

AbstractThere is currently much activity toward the integration of mid-infrared semiconductor lasers on Si substrates for developing a variety of smart, compact, sensors based on Si-photonics integrated circuits. We review this rapidly-evolving research field, focusing on the epitaxial integration of antimonide lasers, the only technology covering the whole mid-to-far-infrared spectral range. We explain how a dedicated molecular-beam epitaxy strategy allows for achieving high-performance GaSb-based diode lasers, InAs/AlSb quantum cascade lasers, and InAs/GaInSb interband cascade lasers by direct growth on on-axis (001)Si substrates, whereas GaAs-on-Si or GaSb-on-Si layers grown by metal-organic vapor phase epitaxy in large capability epitaxy tools are suitable templates for antimonide laser overgrowth. We also show that etching the facets of antimonide lasers grown on Si is a viable approach in view of photonic integrated circuits. Remarkably, this review shows that while diode lasers are sensitive to residual crystal defects, the quantum cascade and interband cascade lasers grown on Si exhibit performances comparable to those of similar devices grown on their native substrates, due to their particular band structures and radiative recombination channels. Long device lifetimes have been extrapolated for interband cascade lasers. Finally, routes to be further explored are also presented.
Metamaterial-enabled arbitrary on-chip spatial mode manipulation
Authors: Xiang Jinlong , Tao Zhiyuan , Li Xingfeng , Zhao Yaotian , He Yu , Guo Xuhan , Su Yikai 
Published: June 2022

AbstractOn-chip spatial mode operation, represented as mode-division multiplexing (MDM), can support high-capacity data communications and promise superior performance in various systems and numerous applications from optical sensing to nonlinear and quantum optics. However, the scalability of state-of-the-art mode manipulation techniques is significantly hindered not only by the particular mode-order-oriented design strategy but also by the inherent limitations of possibly achievable mode orders. Recently, metamaterials capable of providing subwavelength-scale control of optical wavefronts have emerged as an attractive alternative to manipulate guided modes with compact footprints and broadband functionalities. Herein, we propose a universal yet efficient design framework based on the topological metamaterial building block (BB), enabling the excitation of arbitrary high-order spatial modes in silicon waveguides. By simply programming the layout of multiple fully etched dielectric metamaterial perturbations with predefined mathematical formulas, arbitrary high-order mode conversion and mode exchange can be simultaneously realized with uniform and competitive performance. The extraordinary scalability of the metamaterial BB frame is experimentally benchmarked by a record high-order mode operator up to the twentieth. As a proof of conceptual application, an 8-mode MDM data transmission of 28-GBaud 16-QAM optical signals is also verified with an aggregate data rate of 813 Gb/s (7% FEC). This user-friendly metamaterial BB concept marks a quintessential breakthrough for comprehensive manipulation of spatial light on-chip by breaking the long-standing shackles on the scalability, which may open up fascinating opportunities for complex photonic functionalities previously inaccessible.
The SWI/SNF ATPase BRG1 facilitates multiple pro-tumorigenic gene expression programs in SMARCB1-deficient cancer cells
Authors: Moe Kylie C. , Maxwell Jack N. , Wang Jing , Jones Cheyenne A. , Csaki Grace T. , Florian Andrea C. , Romer Alexander S. , Bryant Daniel L. , Farone Anthony L. , Liu Qi , Tansey William P. , Weissmiller April M. 
Published: June 2022

AbstractMalignant rhabdoid tumor (MRT) is driven by the loss of the SNF5 subunit of the SWI/SNF chromatin remodeling complex and then thought to be maintained by residual SWI/SNF (rSWI/SNF) complexes that remain present in the absence of SNF5. rSWI/SNF subunits colocalize extensively on chromatin with the transcription factor MYC, an oncogene identified as a novel driver of MRT. Currently, the role of rSWI/SNF in modulating MYC activity has neither been delineated nor has a direct link between rSWI/SNF and other oncogenes been uncovered. Here, we expose the connection between rSWI/SNF and oncogenic processes using a well-characterized chemical degrader to deplete the SWI/SNF ATPase, BRG1. Using a combination of gene expression and chromatin accessibility assays we show that rSWI/SNF complexes facilitate MYC target gene expression. We also find that rSWI/SNF maintains open chromatin at sites associated with hallmark cancer genes linked to the AP-1 transcription factor, suggesting that AP-1 may drive oncogenesis in MRT. Interestingly, changes in MYC target gene expression are not overtly connected to the chromatin remodeling function of rSWI/SNF, revealing multiple mechanisms used by rSWI/SNF to control transcription. This work provides an understanding of how residual SWI/SNF complexes may converge on multiple oncogenic processes when normal SWI/SNF function is impaired.
Initial findings on RESTORE for healthcare workers: an internet-delivered intervention for COVID-19-related mental health symptoms
Authors: Trottier Kathryn , Monson Candice M. , Kaysen Debra , Wagner Anne C. , Liebman Rachel E. , Abbey Susan E. 
Published: June 2022

AbstractMany healthcare workers on the frontlines of the COVID-19 pandemic are experiencing clinical levels of mental health symptoms. Evidence-based interventions to address these symptoms are urgently needed. RESTORE (Recovering from Extreme Stressors Through Online Resources and E-health) is an online guided transdiagnostic intervention including cognitive-behavioral interventions. It was specifically designed to improve symptoms of anxiety, depression, and posttraumatic stress disorder (PTSD) associated with COVID-19-related traumatic and extreme stressors. The aims of the present study were to assess the feasibility, acceptability, and initial efficacy of RESTORE in healthcare workers on the frontline of the COVID-19 pandemic. We conducted an initial uncontrolled trial of RESTORE in 21 healthcare workers who were exposed to COVID-19-related traumatic or extremely stressful experiences in the context of their work and who screened positive for clinical levels of anxiety, depression, and/or PTSD symptoms. RESTORE was found to be feasible and safe, and led to statistically significant and large effect size improvements in anxiety, depression, and PTSD symptoms over the course of the intervention through follow-up. RESTORE has the potential to become a widely disseminable evidence-based intervention to address mental health symptoms associated with mass traumas.Clinical Trials Registration: This trial was registered with ClinicalTrials.gov ID: NCT04873622
2022 Malaysian Working Group Consensus Statement on Renal Denervation for management of arterial hypertension
Authors: Chia Yook Chin , Wan Ahmad Wan Azman , Fong Alan Yean Yip , Rosman Azhari , Abdul Rahman Abdul Rashid , Choo Gim Hooi , Lim Soo Kun , Abu Bakar Mohammad Zawawi , Ong Tiong Kiam 
Published: June 2022

AbstractHypertension is highly prevalent and a major contributor to cardiovascular mortality and morbidity. In spite of the availability of efficacious, safe and affordable anti-hypertensive drugs, hypertension remains poorly controlled in the majority of hypertensive patients. Various reasons including non-adherence to the anti-hypertensive drugs, account for the poor control. Resistant hypertension is also one of the reasons for poor control of blood pressure (BP). The sympathetic nervous system (SNS) has long been recognized as one of the determinants in the pathophysiology of a raised BP. Overactivity of the SNS is a contributor to sustained arterial hypertension. Renal denervation (RDN) is increasingly recognized as a safe and effective adjunctive therapy to control BP with or without pharmacotherapy. Hence for patients who remain uncontrolled despite all efforts, renal denervation (RDN) is a novel treatment that can potentially improve BP control, hence reducing the major adverse cardiovascular events (MACE). More recent randomized, sham control trials of RDN have shown that RDN produces a sustained lowering of BP. To date, this lowering of BP through RDN is maintained for at least 3 years. Furthermore, this procedure has been found to be safe. Hence this consensus summarises the science behind RDN and the available clinical data to support the use of this therapy. It is hoped that this consensus will offer guidance on the importance of identifying patients who will benefit most from this therapy. A multidisciplinary team approach in the management of the patient undergoing RDN is recommended.
Persister state-directed transitioning and vulnerability in melanoma
Authors: Chauvistré Heike , Shannan Batool , Daignault-Mill Sheena M. , Ju Robert J. , Picard Daniel , Egetemaier Stefanie , Váraljai Renáta , Gibhardt Christine S. , Sechi Antonio , Kaschani Farnusch , Keminer Oliver , Stehbens Samantha J. , Liu Qin , Yin Xiangfan , Jeyakumar Kirujan , Vogel Felix C. E. , Krepler Clemens , Rebecca Vito W. , Kubat Linda , Lueong Smiths S. , Forster Jan , Horn Susanne , Remke Marc , Ehrmann Michael , Paschen Annette , Becker Jürgen C. , Helfrich Iris , Rauh Daniel , Kaiser Markus , Gul Sheraz , Herlyn Meenhard , Bogeski Ivan , Rodríguez-López José Neptuno , Haass Nikolas K. , Schadendorf Dirk , Roesch Alexander 
Published: June 2022

AbstractMelanoma is a highly plastic tumor characterized by dynamic interconversion of different cell identities depending on the biological context. Melanoma cells with high expression of the H3K4 demethylase KDM5B (JARID1B) rest in a slow-cycling, yet reversible persister state. Over time, KDM5Bhigh cells can promote rapid tumor repopulation with equilibrated KDM5B expression heterogeneity. The cellular identity of KDM5Bhigh persister cells has not been studied so far, missing an important cell state-directed treatment opportunity in melanoma. Here, we have established a doxycycline-titratable system for genetic induction of permanent intratumor expression of KDM5B and screened for chemical agents that phenocopy this effect. Transcriptional profiling and cell functional assays confirmed that the dihydropyridine 2-phenoxyethyl 4-(2-fluorophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexa-hydro-quinoline-3-carboxylate (termed Cpd1) supports high KDM5B expression and directs melanoma cells towards differentiation along the melanocytic lineage and to cell cycle-arrest. The high KDM5B state additionally prevents cell proliferation through negative regulation of cytokinetic abscission. Moreover, treatment with Cpd1 promoted the expression of the melanocyte-specific tyrosinase gene specifically sensitizing melanoma cells for the tyrosinase-processed antifolate prodrug 3-O-(3,4,5-trimethoxybenzoyl)-(–)-epicatechin (TMECG). In summary, our study provides proof-of-concept for a dual hit strategy in melanoma, in which persister state-directed transitioning limits tumor plasticity and primes melanoma cells towards lineage-specific elimination.
Full reconstruction of simplicial complexes from binary contagion and Ising data
Authors: Wang Huan , Ma Chuang , Chen Han-Shuang , Lai Ying-Cheng , Zhang Hai-Feng 
Published: June 2022

AbstractPrevious efforts on data-based reconstruction focused on complex networks with pairwise or two-body interactions. There is a growing interest in networks with higher-order or many-body interactions, raising the need to reconstruct such networks based on observational data. We develop a general framework combining statistical inference and expectation maximization to fully reconstruct 2-simplicial complexes with two- and three-body interactions based on binary time-series data from two types of discrete-state dynamics. We further articulate a two-step scheme to improve the reconstruction accuracy while significantly reducing the computational load. Through synthetic and real-world 2-simplicial complexes, we validate the framework by showing that all the connections can be faithfully identified and the full topology of the 2-simplicial complexes can be inferred. The effects of noisy data or stochastic disturbance are studied, demonstrating the robustness of the proposed framework.
The genomic landscape of cholangiocarcinoma reveals the disruption of post-transcriptional modifiers
Authors: Zhang Yaodong , Ma Zijian , Li Changxian , Wang Cheng , Jiang Wangjie , Chang Jiang , Han Sheng , Lu Zefa , Shao Zicheng , Wang Yirui , Wang Hongwei , Jiao Chenyu , Wang Dong , Wu Xiaofeng , Shen Hongbing , Wang Xuehao , Hu Zhibin , Li Xiangcheng 
Published: June 2022

AbstractMolecular variation between geographical populations and subtypes indicate potential genomic heterogeneity and novel genomic features within CCA. Here, we analyze exome-sequencing data of 87 perihilar cholangiocarcinoma (pCCA) and 261 intrahepatic cholangiocarcinoma (iCCA) cases from 3 Asian centers (including 43 pCCAs and 24 iCCAs from our center). iCCA tumours demonstrate a higher tumor mutation burden and copy number alteration burden (CNAB) than pCCA tumours, and high CNAB indicates a poorer pCCA prognosis. We identify 12 significantly mutated genes and 5 focal CNA regions, and demonstrate common mutations in post-transcriptional modification-related potential driver genes METTL14 and RBM10 in pCCA tumours. Finally we demonstrate the tumour-suppressive role of METTL14, a major RNA N6-adenosine methyltransferase (m6A), and illustrate that its loss-of-function mutation R298H may act through m6A modification on potential driver gene MACF1. Our results may be valuable for better understanding of how post-transcriptional modification can affect CCA development, and highlight both similarities and differences between pCCA and iCCA.