bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic literature review of disability weights measurement studies: evolution of methodological choices
Authors: Charalampous Periklis , Polinder Suzanne , Wothge Jördis , von der Lippe Elena , Haagsma Juanita A. 
Published: March 2022

Abstract
Background
The disability weight is an essential factor to estimate the healthy time that is lost due to living with a certain state of illness. A 2014 review showed a considerable variation in methods used to derive disability weights. Since then, several sets of disability weights have been developed. This systematic review aimed to provide an updated and comparative overview of the methodological design choices and surveying techniques that have been used in disability weights measurement studies and how they evolved over time.

Methods
A literature search was conducted in multiple international databases (early-1990 to mid-2021). Records were screened according to pre-defined eligibility criteria. The quality of the included disability weights measurement studies was assessed using the Checklist for Reporting Valuation Studies (CREATE) instrument. Studies were collated by characteristics and methodological design approaches. Data extraction was performed by one reviewer and discussed with a second.

Results
Forty-six unique disability weights measurement studies met our eligibility criteria. More than half (n = 27; 59%) of the identified studies assessed disability weights for multiple ill-health outcomes. Thirty studies (65%) described the health states using disease-specific descriptions or a combination of a disease-specific descriptions and generic-preference instruments. The percentage of studies obtaining health preferences from a population-based panel increased from 14% (2004–2011) to 32% (2012–2021). None of the disability weight studies published in the past 10 years used the annual profile approach. Most studies performed panel-meetings to obtain disability weights data.

Conclusions
Our review reveals that a methodological uniformity between national and GBD disability weights studies increased, especially from 2010 onwards. Over years, more studies used disease-specific health state descriptions in line with those of the GBD study, panel from general populations, and data from web-based surveys and/or household surveys. There is, however, a wide variation in valuation techniques that were used to derive disability weights at national-level and that persisted over time.
Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway
Authors: Chen Zong , Ding Yong , Zeng Ying , Zhang Xue-Ping , Chen Jian-Yan 
Published: March 2022

Abstract
Background
Propofol and dexmedetomidine (DEX) are widely used in general anesthesia, and exert toxic and protective effects on hippocampal neurons, respectively. The study sought to investigate the molecular mechanisms of DEX-mediated neuroprotection against propofol-induced hippocampal neuron injury in mouse brains.

Methods
Hippocampal neurons of mice and HT22 cells were treated with propofol, DEX, and propofol+DEX. In addition, transfection of miR-377-5p mimics or inhibitors was performed in HT22 cells. Neuronal apoptosis was evaluated by a means of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) or Hochest 33,258 staining; Arc positive expression in hippocampus tissues was detected using a microscope in immunohistochemistry assays; miRNA-377-5p expression was quantified by RT-qPCR; the protein levels of Arc, DNMT3A, and DNMT3B were determined using western blot; Cell Counting Kit-8 (CCK-8) assay was used to detect the viability and apoptotic rate of the neurons; methylation analysis in the miR-377-5p promoter was performed through methylated DNA immunoprecipitation (MeDIP) assay; dual luciferase reporter assay was performed to confirm whether Arc was under targeted regulation of miR-377-5p.

Results
In the current study, both in vitro and in vivo, propofol treatment induced hippocampal neuron apoptosis and suppressed cell viability. DNMT3A and DNMT3B expression levels were decreased following propofol treatment, resulting in lowered methylation in the miR-377-5p promoter region and then enhanced expression of miR-377-5p, leading to a decrease in the expression of downstream Arc. Conversely, the expression levels of DNMT3A and DNMT3B were increased following DEX treatment, thus methylation in miR-377-5p promoter region was improved, and miR-377-5p expression was decreased, leading to an increase in the expression of downstream Arc. Eventually, DEX pretreatment protected hippocampal neurons against propofol-induced neurotoxicity by recovering the expression levels of DNMT3A, miR-377-5p, and Arc to the normal levels. Additionally, DNMT3A knockdown improved miR-377-5p expression but reduced Arc expression, and DNMT3A overexpression exerted the opposite effects. Dual luciferase reporter assay revealed a binding target between miR-377-5p and Arc 3’UTR. The neuroprotective effect of DEX against propofol-induced neuronal apoptosis was diminished after Arc knockdown. Silencing Arc independently triggered the apoptosis of HT22 cells, which was alleviated through transfection of miR-377-5p inhibitors.

Conclusions
DEX reduced propofol-induced hippocampal neuron injury via the miR-377-5p/Arc signaling pathway.
Estimating errors in autocorrelation functions for reliable investigations of reflection profiles
Authors: Maeda Yuta , Watanabe Toshiki 
Published: March 2022

AbstractAutocorrelation functions (ACFs) of vertically incident seismic waves are used to image subsurface reflectors. However, the reflection responses derived from ACFs usually contain many false signals. We present a method to quantify the errors in ACFs and extract true reflectors with high reliability. We estimated the errors for each earthquake at each station as follows. We calculated the amplitude of the observed waveform within the noise window and generated 1000 random noise traces that have this amplitude. By subtracting the random noise traces from the observed waveform, we created 1000 candidate earthquake waveforms. We computed the ACF for each of the 1000 waveforms and calculated the ensemble average and standard deviation of the 1000 different ACF amplitudes at each lag time. Then, we applied weighted stacking to the ACFs of many earthquakes to obtain the reflection response at the station. We calculated the standard deviation of the weighted stack to estimate errors in the reflection response. We evaluated the method by applying it to seismic data from the metropolitan area of Japan. The subsurface structure of the study area has been studied extensively and consists of a strong velocity discontinuity between sedimentary and basement layers. Following our method, the discontinuity was imaged as a clear reflector with an amplitude that was substantially greater than three times the standard deviation, which corresponds to statistical significance at the 99% confidence level. At other depths where reflectors are not expected to be present, the amplitudes of the peaks were less than or close to three times the standard deviation. The signal of the discontinuity was clearly visible at frequencies below 10 Hz and was less prominent at higher frequencies.
Graphical Abstract
Specialised early intervention for recent-onset psychosis
Authors: Butt Harun S. 
Published: March 2022

SUMMARYSpecialised early intervention (SEI) services have seen significant investment and expansion in the UK, aiming to improve long-term outcomes for psychotic disorders. This commentary discusses a recent Cochrane review that examines the evidence for SEI services delivered within the first 3 years of onset of psychotic illness. From a small number of studies conducted in high-income countries, the review draws the conclusion that there is low- to moderate-certainty evidence that SEI services improve recovery and reduce disengagement.
Laparoscopic Sentinel Node Navigation Surgery for Stomach Preservation in Patients With Early Gastric Cancer: A Randomized Clinical Trial
Authors: Kim Young-Woo , Min Jae-Seok , Yoon Hong Man , An Ji Yeong , Eom Bang Wool , Hur Hoon , Lee Young Joon , Cho Gyu Seok , Park Young-Kyu , Jung Mi Ran , Park Ji-Ho , Hyung Woo Jin , Jeong Sang-Ho , Kook Myeong-Cherl , Han Mira , Nam Byung-Ho , Ryu Keun Won 
Published: March 2022

PURPOSE To compare postoperative complications, long-term survival, and quality of life (QOL) after laparoscopic sentinel node navigation surgery (LSNNS) and laparoscopic standard gastrectomy (LSG). METHODS Five hundred eighty patients with preoperatively diagnosed stage IA gastric adenocarcinoma (≤ 3 cm) were assigned to undergo either LSG or LSNNS. Observers were not blinded to patient grouping. The primary outcome was 3-year disease-free survival (3y-DFS). Secondary outcomes included postoperative complications, QOL, 3-year disease-specific survival (3y-DSS), and 3-year overall survival (3y-OS). RESULTS In total, 527 patients were included in the modified intention-to-treat analysis population for the primary outcome (LSG, 269; LSNNS, 258). Stomach-preserving surgery was performed in 210 patients (81%) in the LSNNS group. During the median follow-up duration, the 3y-DFS rates in the LSG and LSNNS groups were 95.5% and 91.8%, respectively (difference: 3.7%; 95% CI, –0.6 to 8.1). Three patients with recurrence and five with metachronous gastric cancer in the LSNNS group underwent standard surgery. Two patients with distant metastasis in both groups were treated with palliative chemotherapy. The 3y-DSS and 3y-OS rates in the LSG and LSNNS groups were 99.5% and 99.1% ( P = .59) and 99.2% and 97.6% ( P = .17), respectively. Postoperative complications occurred in 19.0% of the LSG group and 15.5% of the LSNNS group ( P = .294). The LSNNS group showed better physical function ( P = .015), less symptoms ( P < .001), and improved nutrition than the LSG group. CONCLUSION LSNNS did not show noninferiority to LSG for 3y-DFS, with a 5% margin. However, the 3y-DSS and 3y-OS were not different after rescue surgery in cases of recurrence/metachronous gastric cancer, and LSNNS had better long-term QOL and nutrition than LSG.
Multilevel Factors for Adiposity Change in a Population-Based Prospective Study of Black Breast Cancer Survivors
Authors: Qin Bo , Kim Kate , Goldman Noreen , Rundle Andrew G. , Chanumolu Dhanya , Zeinomar Nur , Xu Baichen , Pawlish Karen S. , Ambrosone Christine B. , Demissie Kitaw , Hong Chi-Chen , Lovasi Gina S. , Bandera Elisa V. 
Published: March 2022

PURPOSE Unfavorable weight change after breast cancer diagnosis increases the risk of mortality, but individual and neighborhood risk factors affecting postdiagnosis weight and body fat changes are unclear among Black women, who have higher rates of obesity and mortality than any other racial/ethnic group. METHODS Adiposity changes during the period approximately 10 months-24 months after diagnosis were evaluated among 785 women diagnosed between 2012 and 2018 and enrolled in the Women's Circle of Health Follow-Up Study, a population-based prospective cohort of Black breast cancer survivors in New Jersey. Multilevel factors for weight and fat mass change (with gain or loss defined as a relative difference of 3% or more, and considering whether changes were intentional or unintentional) were estimated using multivariable polytomous logistic regressions and multilevel models. RESULTS Adiposity gain was prevalent: 28% and 47% gained weight and body fat, respectively, despite a high baseline prevalence of overweight or obesity (86%). Risk factors for fat mass gain included receiving chemotherapy (relative risk ratio: 1.59, 95% CI, 1.08 to 2.33) and residing in neighborhoods with a greater density of fast-food restaurants (relative risk ratio comparing highest with lowest tertile: 2.18, 95% CI, 1.38 to 3.46); findings were similar for weight gain. Only 9% of women had intentional weight loss, and multilevel risk factors differed vastly from unintentional loss. CONCLUSION Both individual and neighborhood factors were associated with adiposity change among Black breast cancer survivors. Residential environment characteristics may offer clinically meaningful information to identify cancer survivors at higher risk for unfavorable weight change and to address barriers to postdiagnosis weight management.
Coupling-induced periodic windows in networked discrete-time systems
Authors: Hallier Leonard , Medeiros Everton S. , Mihara Antonio , Medrano-T Rene O. , Zakharova Anna 
Published: March 2022

Abstract
Networked nonlinear systems present a variety of emergent phenomena as a result of the mutual interactions between their units. An interesting feature of these systems is the presence of stable periodic behavior even when each unit oscillates chaotically if in isolation. Surprisingly, the mechanism in which the network interaction replaces chaos by periodicity is still poorly understood. Here, we show that such an onset of regularity can occur via replication of periodic windows. This phenomenon multiplies the stability domains in the system parameter space, not only suppressing chaos but also making the network less vulnerable to external disturbances such as shocks and noise. Moreover, we observe that the network cluster synchronizes for the parameters corresponding to the replica periodic windows. To confirm these observations, we employ the formalism of the master stability function demonstrating that the complete synchronized state is indeed transversally unstable in the replica windows.
Kisspeptin Overcomes GnRH Neuronal Suppression Secondary to Hyperprolactinemia in Humans
Authors: Hoskova Katerina , Kayton Bryant Nora , Chen Margaret E , Nachtigall Lisa B , Lippincott Margaret F , Balasubramanian Ravikumar , Seminara Stephanie B 
Published: March 2022

Abstract

Context
Hyperprolactinemia suppresses gonadotropin-releasing hormone (GnRH)-induced luteinizing hormone (LH) pulses. The hypothalamic neuropeptide kisspeptin potently stimulates the secretion of GnRH. The effects of exogenous kisspeptin administration on GnRH pulse generation in the setting of hyperprolactinemia have not previously been explored.

Objective
This work aimed to examine the effects of kisspeptin on GnRH secretion, as reflected by LH secretion, in women with hyperprolactinemia.

Methods
Women with hyperprolactinemia (n = 11) participated in two 12-hour visits. Before study visits, participants underwent washout of dopamine agonist and/or combined oral contraceptive. Frequent blood sampling was performed (1 sample was collected every 10 minutes). Visit 1 involved no intervention, to examine baseline LH pulsatility. During visit 2, kisspeptin 112–121 (0.24 nmol/kg) was administered every 1 hour, for 10 hours. At hour 11, one intravenous bolus of GnRH (75 ng/kg) was administered.

Results
Repetitive intravenous bolus kisspeptin administration increased the total number of LH pulses in the setting of hyperprolactinemia. The interpulse interval declined during the same time frames. LH pulse amplitude did not change, but the mean LH rose. In 6 participants with progesterone levels suggestive of an anovulatory state, mean LH and estradiol levels increased significantly at visit 2. In the entire cohort, follicle-stimulating hormone and prolactin levels did not change significantly across the 2 visits. A total of 73% of subjects exhibited an LH pulse within 30 minutes of first kisspeptin dose.

Conclusion
Kisspeptin is capable of stimulating hypothalamic GnRH-induced LH pulses in the setting of hyperprolactinemia.
Serum Testosterone Levels in 3-Month-Old Boys Predict Their Semen Quality as Young Adults
Authors: Scheutz Henriksen Louise , Holm Petersen Jørgen , Skakkebæk Niels E , Jørgensen Niels , Virtanen Helena E , Priskorn Lærke , Juul Anders , Toppari Jorma , Main Katharina M 
Published: March 2022

AbstractContextIt remains unknown how the postnatal activation of the hypothalamic-pituitary-gonadal axis in infancy, also known as “minipuberty”, relates to adult testis function.ObjectiveTo investigate how markers of reproductive function in 3-month-old boys correlate with adult reproductive health parameters.MethodsThis population-based birth cohort study (the Copenhagen Mother-Child cohort), conducted at Copenhagen University Hospital, Denmark, included 259 boys examined once around 3 months of age and again at 18 to 20 years. Reproductive hormones, penile length, testis volume, and semen quality were analyzed. Minipubertal markers of testis function (by tertiles, T1–T3) were explored as predictors of adult semen quality using linear regression models. Associations between reproductive outcomes in infancy and young adulthood were estimated by intraclass correlation coefficients (ICCs), describing how well measurements in infancy correlate with those in adulthood.ResultsSerum testosterone concentration in infancy was positively associated with adult total sperm count. Median (IQR) total sperm count was 84 (54-138) million spermatozoa for boys in T1, 141 (81-286) million spermatozoa in T2, and 193 (56-287) million spermatozoa in T3. We found the highest ICC for FSH (0.41; 95% CI, 0.26–0.57), while ICCs for inhibin B, SHBG, penile length, and testis volume ranged between 0.24 and 0.27. ICCs for LH and for total and free testosterone were lower and statistically nonsignificant.ConclusionSerum testosterone in infancy was a predictor of adult total sperm count. Other reproductive hormones and genital measures showed good correlation between infancy and adulthood, suggesting that an individual’s reproductive setpoint starts shortly after birth in boys and persists until adulthood.
Effects of Hormone Therapy and Exercise on Bone Mineral Density in Healthy Women—A Systematic Review and Meta-analysis
Authors: Born Clara , Jakob Franz , Shojaa Mahdieh , Kohl Matthias , von Stengel Simon , Kerschan-Schindl Katharina , Lange Uwe , Thomasius Friederike , Kemmler Wolfgang 
Published: March 2022

Abstract

Context
There is some evidence that an adequate “anabolic hormonal milieu” is essential for the mechanosensitivity/transduction/response of bone tissue.

Objective
This work aimed to determine whether enhancing hormone therapy (HT) with exercise increases the isolated effect of HT on bone mineral density (BMD) at the lumbar spine (LS) and femoral neck (FN).

Methods
A comprehensive search of 6 electronic databases according to the PRISMA statement up to April 28, 2021, included controlled trials longer than 6 months with 3 study arms: (a) HT, (b) exercise, and (c) HT plus exercise (HT + E). Apart from HT, no pharmaceutic therapy or diseases with relevant osteoanabolic or osteocatabolic effect on bone metabolism were included. The present analysis was conducted as a random-effects meta-analysis. Outcome measures were standardized mean differences (SMD) for BMD changes at the LS and FN.

Results
Our search identified 6 eligible studies (n = 585). Although the effect of HT + E was more pronounced in the LS (SMD: 0.19; 95% C,: –0.15 to 0.53) and FN-BMD (0.18; –0.09 to 0.44) compared to the HT group, we did not observe significant differences between the 2 groups. We observed a low (I2: 29%) or moderate (I2: 49%) level of heterogeneity between the trials for FN or LS.

Conclusion
We do not observe a significant effect of HT + E vs HT alone. We largely attribute this result to varying HT supplementation and hormonal status. Bearing in mind that synergistic/additive effects between HT and mechanical stimulation can only be expected in situations of hormonal insufficiency, further clinical studies should consider baseline endogenous estrogen production but also HT dosing more carefully.
Elevated numbers of infiltrating eosinophils accelerate the progression of Duchenne muscular dystrophy pathology in mdx mice
Authors: Theret Marine , Rempel Lucas , Hashimoto Joshua , Ritso Morten , Tung Lin Wei , Li Fang Fang , Messing Melina , Hughes Michael , McNagny Kelly , Rossi Fabio 
Published: March 2022

ABSTRACT
Eosinophils, best known for their role in anti-parasitic responses, have recently been shown to actively participate in tissue homeostasis and repair. Their regulation must be tightly controlled, as their absence or hyperplasia is associated with chronic disease (e.g. asthma or inflammatory bowel disease). In the context of skeletal muscle, eosinophils play a supportive role after acute damage. Indeed, their depletion leads to strong defects in skeletal muscle regeneration and, in the absence of eosinophil-secreted interleukin (IL) 4 and IL13, fibro-adipogenic progenitors fail to support muscle stem cell proliferation. However, the role of eosinophils in muscular dystrophy remains elusive. Although it has been shown that eosinophils are present in higher numbers in muscles from mdx mice (a mouse model for Duchenne muscular dystrophy), their depletion does not affect muscle histopathology at an early age. Here, we evaluated the impact of hyper-eosinophilia on the development of fibrofatty infiltration in aged mdx mice and found that muscle eosinophilia leads to defects in muscle homeostasis, regeneration and repair, and eventually hastens death.
Long duration advertisement calls of nesting male plainfin midshipman fish are honest indicators of size and condition
Authors: Balebail Sujay , Sisneros Joseph A. 
Published: March 2022

ABSTRACTThe plainfin midshipman fish (Porichthys notatus) has long served as a model organism for neuroethology research on acoustic communication and related social behaviors. Type I or ‘singing’ males produce highly stereotyped, periodic advertisement calls that are the longest known uninterrupted vertebrate vocalizations. Despite the extensive literature on the acoustic behaviour of this species, it remains unclear whether reproductive males signal their quality via their highly energetic, multiharmonic advertisement calls. Here, we recorded the advertisement calls of 22 reproductive type I males at night in a controlled laboratory setting in which males were housed in aquaria maintained at a constant temperature (13.9±0.3°C). The duration of the advertisement calls from type I males was observed to increase from the first call of the night to the middle call after which call duration remained steady until the early morning hours and first light. A strong positive correlation was observed between loudness (sound pressure level and maximum sound pressure level) of the advertisement call and body size (mass and standard length; rs&gt;0.8). In addition, an asymptotic relationship was observed between the harmonic frequencies (f0–f10) of the advertisement calls and male body condition, with harmonic frequencies initially increasing with body condition indices, but then plateauing when body condition measures were high. Taken together, our results suggest that type I male advertisement calls provide reliable honest information about male quality regarding size and body condition. Such condition-dependent information of calling males could potentially be used by receptive females to help facilitate mate choice decisions.