bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generating multiple resonances in ultrathin silicon for highly selective THz biosensing
Authors: Khan Mohd Salman , Giri Pushpa , Varshney Gaurav 
Published: July 2022

Abstract
A technique is implemented for achieving the multiband terahertz (THz) absorption with high-quality factor in an absorber containing an ultrathin silicon resonator. The symmetrical perturbation is done in the silicon layer for obtaining the multiple multi-order electric and magnetic resonances. The proposed absorber structure provides the polarization insensitive absorption spectrum with ten absorption peaks out of which seven remain with the level of more than 90%. The ultranarrow absorption spectrum can be utilized in THz biosensing applications specially for the detection of breast cancer, malaria in blood and glucose in water. It offers highest sensitivity as 0.416 THz/thickness unit (TU) and 1.02 THz/refractive index unit (RIU) during analyte thickness and refractive index sensing, respectively. The proposed absorber can provide the high value of quality factor along with all other improved parameters like sensitivity and figure of merit. Moreover, graphene nano-rings can also be utilized for obtaining the controllability in the frequency response of the absorber.
First wall power flux management during plasma current ramp-up on ITER
Authors: Pitts R.A. , Gribov Y. , Coburn J. , Fuentes F.J. , Severino G. , Vayakis G. , Amoskov V. , Brank M. , Carpentier S. , D’Amico G. , Dubrov M.L. , Fernández-Marina F. , Jong C. , Kavin A.A. , Khayrutdinov R. , Kocan M. , Lamzin E. , Loarte A. , Kos L. , Lukash V.E. , Mitchell N. , Raffray A.R. , Simič G. , Stangeby P.C. , Sytchevsky S. 
Published: July 2022

Abstract
On ITER, plasma start-up will be performed in limiter configuration on the inboard equatorial beryllium first wall panels (FWP). In contrast to most present tokamaks, however, this ramp-up phase will be comparatively long (∼10 s) and the use of actively cooled components means that power flux management is key if FWP lifetime is not to be compromised. Shaping of the FWPs is mandatory to ensure that leading edges do not appear between neighbouring units. For the ITER inboard panels, this has been optimized to account for the discovery in recent years on current devices of narrow scrape-off layer power flux channels for inner wall limited plasmas. However, the shaping results in power densities which are particularly sensitive to the overall ‘longwave’ (LW) alignment of the central column FWP ring with the structure of the toroidal magnetic field (TF), placing tight constraints on the target alignment. This target is currently based on a pure n = 1 LW alignment, but simulations of TF coil (TFC) locking upon energization show that, depending on the initial configuration of the gaps between the TFC inner legs, the field structure can be more complex. Although the TFC manufacture and machine assembly strategy is to make every effort possible to approach the ideal TF structure, an NMR sensor-based TF mapping diagnostic will be implemented to measure the field structure during the first plasma and engineering operation phase. An analytic framework has been developed and verified against numerical simulations to assess the capability for measurements from a set of discrete sensors located on the vacuum vessel inner column to be used to reconstruct the field structure at the FWP locations, a further ∼60 cm radially inward. In parallel with the alignment optimization and TF mapping strategies, modified ramp-up scenarios are also being designed which may be used to reduce inner wall limiter power fluxes if this proves to be necessary during operation.
Effect of graphene oxide on strength and interfacial transition zone of recycled aggregate concrete
Authors: Qidong Wang , Changshun Zhou , Xudong Wang , Zixuan An , Yeke Luo 
Published: July 2022

Abstract
This paper studies the effect of graphene oxide (GO) on the strength and interface transition zone of recycled aggregate concrete (RAC). The results show that the addition of GO enhances the RAC strength, and the compressive strength of the sample containing GO is improved by 7% ∼20.6% at 28 days, compared with the reference group. Meanwhile, with the addition of GO, the total porosity and the number of harmful pores (> 100 nm) of RAC samples decreased by 8.1% ∼35.7% and 3% ∼39.1%, respectively. It is observed from the nano scale characteristics that the addition of GO can significantly reduce pore phase and unhydrated phase content in the matrix, and increase the volume fraction of C–S–H phase, especially the high-density C–S–H phase. In addition, the width of the interface transition zone between old mortar and new mortar containing GO sample is relatively reduced by 25%, but there is no obvious change in the interface transition zone of old aggregate mortar. The strengthening effect of GO on RAC strength is due to the nucleation of GO and the filling effect of micro-aggregate, improving the pore structure and interface transition zone of RAC.
Avoiding C-hacking when evaluating survival distribution predictions with discrimination measures
Authors: Sonabend Raphael , Bender Andreas , Vollmer Sebastian 
Published: July 2022

AbstractMotivationIn this article, we consider how to evaluate survival distribution predictions with measures of discrimination. This is non-trivial as discrimination measures are the most commonly used in survival analysis and yet there is no clear method to derive a risk prediction from a distribution prediction. We survey methods proposed in literature and software and consider their respective advantages and disadvantages.ResultsWhilst distributions are frequently evaluated by discrimination measures, we find that the method for doing so is rarely described in the literature and often leads to unfair comparisons or ‘C-hacking’. We demonstrate by example how simple it can be to manipulate results and use this to argue for better reporting guidelines and transparency in the literature. We recommend that machine learning survival analysis software implements clear transformations between distribution and risk predictions in order to allow more transparent and accessible model evaluation.Availability and implementationThe code used in the final experiment is available at https://github.com/RaphaelS1/distribution_discrimination.
Spatial control of astrogenesis progression by cortical arealization genes
Authors: Santo Manuela , Rigoldi Laura , Falcone Carmen , Tuccillo Mariacarmine , Calabrese Michela , Martínez-Cerdeño Verónica , Mallamaci Antonello 
Published: July 2022

AbstractSizes of neuronal, astroglial and oligodendroglial complements forming the neonatal cerebral cortex largely depend on rates at which pallial stem cells give rise to lineage-committed progenitors and the latter ones progress to mature cell types. Here, we investigated the spatial articulation of pallial stem cells’ (SCs) commitment to astrogenesis as well as the progression of committed astroglial progenitors (APs) to differentiated astrocytes, by clonal and kinetic profiling of pallial precursors. We found that caudal-medial (CM) SCs are more prone to astrogenesis than rostro-lateral (RL) ones, while RL-committed APs are more keen to proliferate than CM ones. Next, we assessed the control of these phenomena by 2 key transcription factor genes mastering regionalization of the early cortical primordium, Emx2 and Foxg1, via lentiviral somatic transgenesis, epistasis assays, and ad hoc rescue assays. We demonstrated that preferential CM SCs progression to astrogenesis is promoted by Emx2, mainly via Couptf1, Nfia, and Sox9 upregulation, while Foxg1 antagonizes such progression to some extent, likely via repression of Zbtb20. Finally, we showed that Foxg1 and Emx2 may be implicated—asymmetrically and antithetically—in shaping distinctive proliferative/differentiative behaviors displayed by APs in hippocampus and neocortex.
Resistance-Guided Therapy for Neisseria gonorrhoeae
Authors: Allan-Blitz Lao-Tzu , Adamson Paul C , Klausner Jeffrey D 
Published: July 2022

Abstract
Antimicrobial-resistant Neisseria gonorrhoeae infections are a threat to public health. Novel strategies for combating such resistance include the development of molecular assays to facilitate real-time prediction of antimicrobial susceptibility. Resistance to ciprofloxacin is determined by the presence of a single mutation at codon 91 of the gyrase A gene; molecular assays to guide therapy are commercially available. Resistance to cefixime is conferred via 1 of 6 critical mutations in either the mosaic penA gene or specific loci in the nonmosaic region. Resistance to ceftriaxone is conferred through mutations in 1 of 4 genes: penA, ponA, penB, and mtr; however, the ability to predict reduced susceptibility based on those genes varies by geographic region. Here, we highlight the work done toward the development of 3 such assays for ciprofloxacin, cefixime, and ceftriaxone, discuss the status of our current understanding and ongoing challenges, and suggest future directions.
DEB-IBM for predicting climate change and anthropogenic impacts on population dynamics of hairtail Trichiurus lepturus in the East China Sea
Authors: Yang Tao , Han Qingpeng , Gorfine Harry , Shan Xiujuan , Ren Jeffrey S 
Published: July 2022

Abstract
The hairtail Trichiurus lepturus supports the largest fisheries in the East China Sea. The stock has fluctuated in the past few decades and this variation has been attributed to human pressures and climate change. To investigate energetics of individuals and population dynamics of the species in responses to environmental variations and fishing efforts, we have developed a DEB-IBM by coupling a dynamic energy budget (DEB) model to an individual-based model (IBM). The parameter estimation of DEB model shows an acceptable goodness of fit. The DEB-IBM was validated with histological data for a period of 38 years. High fishing pressure was largely responsible for the dramatic decline of the stock in middle 1980s. The stock recovered from early 1990s, which coincided with introduction of fishing moratorium on spawning stocks in inshore waters and substantial decrease of fishing efforts from large fisheries companies. In addition, the population average age showed a trend of slight decrease. The model successfully reproduced these observations of interannual variations in the population dynamics. The model was then implemented to simulate the effect of climate change on the population performance under greenhouse gas emission scenarios projected for 2100. It was also used to explore population responses to changing fishing mortalities. These scenario simulations have shown that the population biomass under SSP1-1.9, SSP2-4.5 and SSP5-8.5 would decline by 7.5%, 16.6% and 30.1%, respectively, in 2100. The model predicts that increasing fishing mortality by 10% will cause 5.3% decline of the population biomass, whereas decrease of fishing mortality by 10% will result in 6.8% increase of the biomass. The development of the DEB-IBM provides a predictive tool to inform management decisions for sustainable exploitation of the hairtail stock in the East China Sea.
Prediction of occult atrial fibrillation in patients after cryptogenic stroke and transient ischaemic attack: PROACTIA
Authors: Skrebelyte-Strøm Loreta , Rønning Ole Morten , Dahl Fredrik A , Steine Kjetil , Kjekshus Harald 
Published: July 2022

Abstract

Aims
Studies with implantable cardiac monitors (ICMs) show that one-third of patients with cryptogenic stroke/transient ischaemic attack (TIA) have episodes of subclinical atrial fibrillation (SCAF) and benefit switching from antiplatelet- to anticoagulant therapy. However, ICMs are costly and resource demanding. We aimed to build a score based on participant’s baseline characteristics that could assess individual risk of SCAF.

Methods and results
In a prospective study, 236 eligible patients with a final diagnosis of cryptogenic stroke/TIA had an ICM implantated during the index hospitalization. Pre-specified evaluated variables were: CHA2DS2-VASc, P-wave duration, P-wave morphology, premature atrial beats (PAC)/24 h, supraventricular tachycardia/24 h, left atrial end-systolic volume index (LAVI), Troponin-T, NT-proBNP, and D-dimer. SCAF was detected in 84 patients (36%). All pre-specified variables were significantly associated with SCAF detection in univariate analysis. P-wave duration, followed by PAC/24 h, NT-proBNP, and LAVI, had the largest ratio of SCAF prevalence between its upper and lower quartiles (3.3, vs. 3.2, vs. 3.1 vs. 2.8, respectively). However, in a multivariate analysis, only PAC/24t, P-wave duration, P-wave morphology, and LAVIs remained significant predictors and were included in the PROACTIA score. Subclinical atrial fibrillation prevalence was 75% in the highest vs. 10% in the lowest quartile of the PROACTIA score with a 10-fold higher number of patients with an atrial fibrillation burden &gt;6 h in the highest vs. the lowest quartile.

Conclusion
The PROACTIA score can identify patients with cryptogenic stroke/TIA at risk of subsequent SCAF detection. The large difference in SCAF prevalence between groups may provide a basis for future tailored therapy.

Clinical trial registration
Clinical Trial Registration: ClinicalTrials.gov; NCT02725944.
Geometric Nature of Relations on Plabic Graphs and Totally Non-negative Grassmannians
Authors: Abenda Simonetta , Grinevich Petr G 
Published: July 2022

Abstract
The standard parametrization of totally non-negative Grassmannians was obtained by A. Postnikov [45] introducing the boundary measurement map in terms of discrete path integration on planar bicoloured (plabic) graphs in the disc. An alternative parametrization was proposed by T. Lam [38] introducing systems of relations at the vertices of such graphs, depending on some signatures defined on their edges. The problem of characterizing the signatures corresponding to the totally non-negative cells was left open in [38]. In our paper we provide an explicit construction of such signatures, satisfying both the full rank condition and the total non-negativity property on the full positroid cell. If each edge in a graph $\mathcal G$ belongs to some oriented path from the boundary to the boundary, then such signature is unique up to a vertex gauge transformation. Such signature is uniquely identified by geometric indices (local winding and intersection number) ruled by the orientation $\mathcal O$ and the gauge ray direction $\mathfrak l$ on $\mathcal G$. Moreover, we provide a combinatorial representation of the geometric signatures by showing that the total signature of every finite face just depends on the number of white vertices on it. The latter characterization is a Kasteleyn-type property in the case of bipartite graphs [1, 7], and has a different statistical mechanical interpretation otherwise [6]. An explicit connection between the solution of Lam’s system of relations and the value of Postnikov’s boundary measurement map is established using the generalization of Talaska’s formula [51] obtained in [6]. In particular, the components of the edge vectors are rational in the edge weights with subtraction-free denominators. Finally, we provide explicit formulas for the transformations of the signatures under Postnikov’s moves and reductions and amalgamations of networks.
The prognostic value of S-100 protein and Ki-67 index in olfactory neuroblastoma
Authors: Wang Jie , Wang Weifang , Wang Li , Tang Tianci , Hu Chunyan , Song Xinmao 
Published: July 2022

Abstract

Objective
To evaluate the prognostic value of S-100 protein and Ki-67 labeling index in olfactory neuroblastomas.

Methods
A retrospective study was conducted on a cohort of 85 patients with olfactory neuroblastomas. The immunohistochemical expression of S-100 and Ki-67 was assessed, and the predictive value of S-100 and Ki-67 was further evaluated. The optimal cutoff value of Ki-67 labeling index was determined using time-dependent receiver operating characteristic curve analysis. Overall survival and progression-free survival were assessed using the Kaplan–Meier method.

Results
A cut-off Ki-67 labeling index value of 67.5% was determined for prognosis in patients with olfactory neuroblastomas. There was a significant correlation between Ki-67 expression and cervical lymph node metastasis (P = 0.049). Compared with S-100 (+), S-100 (−) was associated with a higher rate of lymph node metastasis and a higher level of Ki-67 (P = 0.007, &lt; 0.001, respectively), as well as an advanced Kadish stage (P = 0.037). Survival analyses showed that patients with S-100 (+) had better 5-year overall survival than those with S-100 (−) (P = 0.028), and patients with both S-100 (+) and Ki-67 (&lt;67.5%) had superior 5-year overall survival compared with all the other patients (P = 0.0225).

Conclusion
Our findings suggest that S-100 combined with Ki-67 labeling index are reliable prognostic factors in patients with olfactory neuroblastomas.
Dexmedetomidine Inhibits NF-κB-Transcriptional Activity in Neurons Undergoing Ischemia-Reperfusion by Regulating O-GlcNAcylation of SNW1
Authors: She Chang , Zhu Jiahua , Liu An , Xu Yangting , Jiang Zhengqian , Peng Ya 
Published: July 2022

Abstract
Dexmedetomidine (Dex) is neuroprotective in ischemia-reperfusion (I/R) by suppressing inflammation but the underlying molecular mechanisms are not known. SNW domain-containing protein 1 (SNW1) is a coactivator of the pro-inflammatory transcription factor NF-κB p65. Because SNW1 is regulated by O-GlcNAcylation, we aimed to determine whether this modification influences NF-κB transcriptional activity in neurons undergoing I/R and how Dex may affect the O-GlcNAcylation of SNW1. SH-SY5Y and PC12 cells under hypoxia/reoxygenation (H/R) conditions were treated with Dex and with inhibitors of O-GlcNAc transferase (OGT). O-GlcNAc levels in SNW1 and effects of SNW1 on NF-κB p65 were determined by immunoprecipitation. H/R increased SNW1 protein levels but inhibited O-GlcNAcylation of SNW1. A Luciferase reporter assay demonstrated that increased SNW1 levels led to increased NF-κB p65 activity and increased secretion of neuron-derived inflammatory factors demonstrated by ELISA. Dex reversed the H/R-induced increase of SNW1 protein by upregulating OGT and enhancing O-GlcNAcylation of SNW1. Dex suppression of the SNW1/NF-κB complex resulted in neuroprotection in vitro and in a middle cerebral artery occlusion model in vivo. PKA and ERK1/2 inhibitors abolished the effect of Dex on OGT protein. Taken together, these data indicate that Dex inhibits NF-κB-transcriptional activity in neurons undergoing I/R by regulating O-GlcNAcylation of SNW1.
Trajectories of Marital Satisfaction among Parents of Youth with Spina Bifida
Authors: Kritikos Tessa K , Winning Adrien M , Smith Zoe R , Holmbeck Grayson N 
Published: July 2022

AbstractObjectiveThis study examined marital satisfaction among parents of youth with spina bifida (SB) over an 8-year period and investigated the usefulness of the double ABCX model for understanding factors that predict change in marital satisfaction across child age.MethodsData from five time points of a longitudinal investigation of psychosocial outcomes in youth with SB were included. Mothers and fathers of children with SB (aged 8–17) reported on marital satisfaction and components of the double ABCX model. Change in marital satisfaction was examined across child age with components of the double ABCX model, as well as interactions between components, as predictors.ResultsMarital satisfaction was significantly higher in the present sample than in a normative sample of married couples. Although there were no significant changes in marital satisfaction for either parent as a function of child age, there was significant variability for the intercept and slope of maternal and paternal marital satisfaction within the sample. Family support predicted a higher intercept, and mental health symptoms predicted a lower intercept, for maternal and paternal marital satisfaction. More stressors and SB-related family stress predicted a lower intercept for paternal marital satisfaction. Family support and family stress attributed to SB moderated the relationship between child vulnerability and maternal marital satisfaction. Observed family cohesion and child psychosocial quality of life moderated the relationship between family stressors and paternal marital satisfaction.ConclusionFindings demonstrate the usefulness of the double ABCX model for this population.
Propensity score-based analysis of stereotactic body radiotherapy, lobectomy and sublobar resection for stage I non-small cell lung cancer
Authors: Kishi Noriko , Matsuo Yukinori , Menju Toshi , Hamaji Masatsugu , Nakakura Akiyoshi , Hanazawa Hideki , Takehana Keiichi , Date Hiroshi , Mizowaki Takashi 
Published: July 2022

Abstract
We applied two propensity score-based analyses to simultaneously compare three treatment modalities—stereotactic body radiotherapy (SBRT), lobectomy, or sublobar resection (SLR)—for stage I non-small cell lung cancer (NSCLC), with the aim of clarifying the average treatment effect (ATE) and formulating a risk-adapted approach to treatment selection. A retrospective review of 823 patients aged ≥65 years who underwent SBRT, lobectomy, or SLR for stage I NSCLC was conducted. The following two analyses using machine learning-based propensity scores were performed: (i) propensity score weighting (PSW) to assess the ATE in the entire cohort, and (ii) propensity score subclassification (PSS) to evaluate treatment effects of subgroups. PSW showed no significant difference in the 5-year overall survival (OS) between SBRT and SLR (60.0% vs 61.2%; P = 0.70) and significant difference between SBRT and lobectomy (60.0% vs 77.6%; P = 0.026). Local (LR) and distant recurrence (DR) rates were significantly lower in lobectomy than in SBRT, whereas there was no significant difference between SBRT and SLR. PSS identified four subgroups with different patient characteristics: lobectomy-oriented (5-year cumulative incidences of non-lung cancer death, 7.5%), SLR-oriented (14.2%), SBRT-oriented (23.8%) and treatment-neutral subgroups (16.1%). Each subgroup showed different survival trends regarding the three treatments. The ATE of SBRT was not significantly different from that of SLR, but it was inferior to lobectomy. Four subgroups with different risks of non-lung cancer death and different survival trends for each treatment were identified. These would help decision-making for patients with stage I NSCLC.
Momentum and energy injection by a wind-blown bubble into an inhomogeneous interstellar medium
Authors: Pittard J M 
Published: July 2022

Abstract
We investigate the effect of mass-loading from embedded clouds on the evolution of wind-blown bubbles. We use 1D hydrodynamical calculations and assume that the clouds are numerous enough that they can be treated in the continuous limit, and that rapid mixing occurs so that the injected mass quickly merges with the global flow. The destruction of embedded clouds adds mass into the bubble, increasing its density. Mass-loading increases the temperature of the unshocked stellar wind due to the frictional drag, and reduces the temperature of the hot shocked gas as the available thermal energy is shared between more particles. Mass-loading may increase or decrease the volume-averaged bubble pressure. Mass-loaded bubbles are smaller, have less retained energy and lower radial momentum, but in all cases examined are still able to do significant PdV work on the swept-up gas. In this latter respect, the bubbles more closely resemble energy-conserving bubbles than the momentum-conserving-like behaviour of ‘quenched’ bubbles.