bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the Change of Antiemetic Prophylaxis From a Double Combination to a Triple Combination in Oncology Patients With High Dose Carboplatin Chemotherapy
Authors: Marta Albanell-Fernández , Ángela Pérez Sánchez , Inés Monge Escartín , Gisela Riu Viladoms , Carmen Rodríguez Mues Mª , Lourdes Corominas Bosch Mª , Neus Basté Rollán , Noemí Reguart , Maribel Reyes Roxana , Lydia Gaba García , Dolors Soy Muner , Esther Carcelero San Martín 
Published: December 2022

Abstract
Purpose:To compare the effectiveness of netupitant/palonosetron and dexamethasone triple combination(TC) therapy versus ondansetron/dexamethasone double combination(DC) therapy as antiemetic prophylaxis in patients with solid tumors after a moderated emetic regiment of carboplatin AUC≥4. As a secondary endpoint, in TC group we evaluated the effectiveness of changing NEPA administration timing from 1 hour to 15 minutes before chemotherapy.
Methods:Single institution prospective study in which assignment to groups was not randomized. Patients receiving carboplatin AUC≥4 enrolled the study. Chemotherapy-induced nausea and vomiting (CINV) was evaluated using MASCC antiemetic tool, in acute (<24h) and delayed phase (24–120h), in DC vs TC. Results were analyzed using χ2 test.
Results:Two-hundred four completed questionnaires (CQ) were analyzed, 76 belonging to DC and 128 to TC. The proportion of patients who remained emesis-free was superior for TC-treated group compared to DC, either in acute (99.2% vs 92%, p=0.0109) and delayed phase (97.6% vs 90.5%, p=0.042). Likewise, a higher proportion of TC-treated patients compared to DC, remained nausea-free for the first 24 hours after treatment (90.6% vs 72%, p=0.0005) and after 120 hours (82.3% vs 63.5%, p=0.0031). Comparison of the change in NEPA administration time showed similar effectiveness in terms of CINV control (81.6% vs 74.5% p=0.70).
Conclusions:A triple antiemetic combination should be used in carboplatin AUC≥4 regimens. TC showed superiority in early and delayed CINV control, with no significant differences among different cancer types. Change in NEPA administration timing has beneficial implications; it allows NEPA to be administered at hospital, before chemotherapy session, instead of at home.
Flyrock risk assessment in blasting operations
Authors: Davarzani Mohammad Reza , Ataei Mohammad , Sereshki Farhang 
Published: December 2022

Abstract
Creating a safe environment is one of the most main indicators in any project. This research has been carried out with the aim of identifying the risks related to flyrock in blasting operations in the road construction project in hard rock. Flyrock is one of the destructive consequences of blasting operations, which occurs in the form of uncontrolled and unintentional flyrock fragments out of the blast area with high energy and speed. These stone pieces Sometimes their hit of people and Equipment can lead to irreparable injuries. 54 flyrock events were identified and prioritized with the help of experts and review of scientific records and observation and inspection. A fault tree was created for the risk of flyrock that was analyzed as a top event. The opinions of 10 experts on the probability rate of flyrock were completed using the method of linguistic variables. Experts were awarded points using the significance coefficient table of each expert. Using mathematical relations, the consensus of experts was calculated fuzzily. The resulting numbers were fuzzy using the relationships. The probability rate of the flyrock event was calculated under uncertainty 0.4907.
Intraoperative nerve monitoring during minimally invasive esophagectomy and 3-field lymphadenectomy: Safety, efficacy and feasibility
Authors: Gopinath Srinivas Kodaganur , Jiwnani Sabita , Valiyuthan Parthiban , Parab Swapnil , Niyogi Devayani , Tiwari Virendrakumar , Pramesh CS 
Published: December 2022

Abstract
Purpose
To demonstrate the safety, efficacy and feasibility of intraoperative monitoring of the recurrent laryngeal nerves during thoracoscopic and robotic 3-field esophagectomies.
Methods
This is a retrospective analysis of our initial experience with intra operative nerve monitoring during minimally invasive 3-field esophagectomies. Data were obtained from a prospectively maintained database and electronic medical records. To compare outcomes between IONM and non IONM group Fischer’s exact test was used. All patients underwent a minimally invasive(VATS/Robotic) transthoracic esoohagectomy with a neck anastomosis (McKeown procedure). Intraoperative nerve monitoring was carried out under general anesthesia with assisted ventilation and avoiding use of neuromuscular blockers during the period of nerve monitoring.
Results
24 patients underwent nerve monitoring during minimally invasive 3-field esophagectomy. 15 patients were operated thoraco-laparosopically and 9 patients underwent a robotic-assisted procedure. 8/24 (33.3%) patients had vocal cord paresis in the immediate post op period. When we compared this to a historical cohort operated in the preceding 5 years in the same institution, we demonstrated a 26% reduction in nerve palsy rate(p-0.08). On follow-up, 6/8 patients reported returning to a normal voice.
Conclusions
Intra-operative neuro monitoring (IONM) is feasible during minimally invasive 3- field esophagectomy. Using this can potentially lead to a reduced rate of recurrent nerve palsies and a higher nodal yield.
Employing QSAR to design synthetic accessible TRPM8 Inhibitors
Authors: Mendonça Carla Caroline Ribeiro , Viana Jéssika Oliveira , Jordão Alessandro Kappel , BARBOSA EUZEBIO 
Published: December 2022

Abstract

In this work, 53 α-phenylglycine amides were analyzed by a diverse range of in silico approaches like activity cliff, molecular docking, molecular dynamics and 3D-QSAR model construction. The analysis assisted the design new compounds that could potentially inhibit the Transient Receptor Potential Melastatin 8 (TRPM8). This non-selective cation channel has a link with some diseases such as migraine, overactive bladder, and prostate cancer. A hybrid QSAR model, with acceptable figures of merit (R2adj = 0.87, Q2LOO = 0.86, Q2ext = 0.75), was used to predict the pIC50 for various designed structures. The synthetic routes employed in previous works was used to guide structure planning ensuring synthetic accessibility. Druglikeness properties were analyzed by the SwissADME website to filter out non-suitable compounds. It was possible to create four prototypes with higher pIC50. All designed compounds can be readily synthesized and tested for TRPM8 inhibition.
Aspirin inhibited the Warburg effect induced by Ni-refining fumes via the Wnt/β-catenin pathway in Beas-2B cells
Authors: Gao Ying , Zhang Tong , Zhang Dan , Wang Sheng-Yuan , Wang Yue , Yu Cui-Ping , Wang Rui , Yang Shi-Kuan , Li Li-Na , Yao Wen-Xue , Wu Yong-Hui 
Published: December 2022

Abstract

The natural metal nickel (Ni) can be found in the air, water, sediment, and soil. Although epidemiological research and experimental data have shown that nickel is linked to lung cancer, the precise mechanism of nickel carcinogenesis is unclear. We investigated whether Ni-refining fumes stimulated the Wnt/β-catenin pathway and caused the Warburg effect in Beas-2B cells, then if aspirin could protect the cells. The findings demonstrated that Beas-2B cells were significantly toxicated by Ni-refining fumes. With the increase of Ni-refining fumes concentration, the proteins and mRNAs level of the Wnt/β-catenin pathway were significantly increased and Warburg effect-related proteins: pyruvate dehydrogenase kinase 1 (PDK1), monocarborxylat transporter 1 (MCT1) and lactate dehydrogenase A (LDHA) also increased significantly. Pyruvate dehydrogenase (PDH) activity was reduced and reactive oxygen species (ROS) production was increased. When given the Wnt/β-catenin pathway inhibitor XAV-939, Warburg effect-related proteins expression can be inhibited. Aspirin at various concentrations could improve the relative viability of cells exposed to nickel refining fumes, with 2.5 mmol/L aspirin providing the most significant protection (P<0.05). Compared with the nickel staining group, aspirin treatment significantly decreased the expression of the Wnt/β-catenin pathway and Warburg effect-related proteins whereas it inhibited the production of ROS, too.
Fixed Point Theorems for Upper Semicontinuous Set-valued Mappings in p-Vector Spaces
Authors: Yuan George Xianzhi 
Published: December 2022

Abstract

The goal of this paper is to establish a general fixed point theorem for upper semicontinuous set-values mappings in p-vector spaces (p∈(0, 1]), which include topological vector spaces as a special class. These new results provide an answer to Schauder conjecture in the affirmative under the setting of p-vector spaces for set-valued mappings, which would be fundamental for nonlinear functional analysis in mathematics.
AMS Classification: 47H04, 47H10, 46A16, 46A55, 49J27, 49J35, 52A07, 54C60, 54H25, 55M20
A Novel Scaffold Based on Biopolymers and Gallium-Containing Hydroxyapatite as Green Technology
Authors: Alves Fândessan Costa , Morais Alan Ícaro Sousa , Santos Ariane M. S. , Lima Idglan Sa , Silva Albert S. , Garcia Ramón R. P. , Braga Aluska N. S. , Osajima Josy A. , Silva-Filho Edson C 
Published: December 2022

Abstract
Waste generated by the textile industry is one of the primary pollutants in aquatic environments. It is estimated that about 10 to 15% of the dyes used do not chemically interact with the fabric fibers, with a loss of this pollutant in the wastewater. One of the alternatives for pollutant removal is the adsorption process, which is viable compared to other separation methods. There is a range of materials that are used in adsorption processes. Among them, polysaccharides have numerous advantages regarding their use: they are non-toxic, abundant in nature, biodegradable, hydrophilic, and have several other properties. The study aimed to investigate a novel scaffold based on biopolymers and gallium-doped hydroxyapatite for dyes removal in an aqueous solution. The scaffold was characterized by X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), thermogravimetric analysis (TGA), scanning electron microscopy, and energy dispersive X-ray spectroscopy (SEM-EDS), swelling and adsorption tests. From the XRD, the gallium presence did not change the crystal structure of hydroxyapatite. The FTIR and TG spectra of the scaffold indicate that there were interactions between the precursor materials in the production of the same by shifting the characteristic bands and increasing thermal stability. SEM showed essential characteristics for the application of scaffolds in the adsorptive process through the presence of pores on the upper side and the inner surface of the scaffold. Open and interconnected pores with average diameters in the range of 60 mm on the upper and lateral face surface and 40 mm on the inside of the scaffold were observed. A more significant number of pores were observed inside, thus influencing the adsorption. In addition, EDS was possible to qualitatively prove the presence of precursor elements for the formation of the scaffold. It is concluded that the scaffolding was successful and showed excellent potential for removing Remazol Blue RGB and Remazol Red with adsorption of 341.41 ± 6.82 and 584.89 ± 23.39 mg/g, respectively.
Optimizing and Reliability Analysis by Firefly and Genetic Algorithms for a Quadcopter
Authors: Gholami AmirHossein , Dehaghi Mahdi Bagherian , Imani Kazem 
Published: December 2022

Abstract

Quadcopters are a special type of unmanned aerial vehicle, which have received a lot of attention today due to their various applications in various fields. Quadcopters, due to their high functionality, the presence of various high-tech elements in them, along with special flight standards, etc., have set the conditions in such a way that the occurrence of any breakdown and fault, even a small one, will incur huge costs. Therefore, reliability estimation is of special importance for these systems. In addition, due to the limitation of financial resources and mass for the quadcopter, the design of a system should be done in such a way as to achieve the highest possible amount of reliability based on our limited resources. In this article, we have tried to obtain the best possible answers by using optimization algorithms while calculating the reliability. In order to increase the reliability of a system, there are several methods including increasing the quality of parts and components, using surplus components, increasing the quality of parts and components the use of surplus components and redesigning the system. In this article, an attempt has been made to increase the reliability of the quadcopter by using redundant components, and for this purpose, firefly algorithms have been used, and genetic algorithms have been used to validate and validate the results obtained. Finally, after running the algorithms 20 times, the optimal reliability values of 0.99925 using the firefly algorithm and 0.99999 using the genetic algorithm were obtained.
Constructing Teacher Identity: Pre-Service Teacher Resilience in School-based Practicum Experiences
Authors: Krisdianata Yoannes Yuka , Mbato Concilianus Laos 
Published: December 2022

<em>Constructing teacher identity is important for pre-service teachers, especially when taking part in teacher training practicums in school. Nonetheless, they faced many adversities, such as passive students, negative emotions, and anxiety. Therefore, pre-service teachers need to be aware of their capacity for resilience. This study aimed to discover the resilience factors pre-service teachers had in coping with the problems found in teacher training practicums in schools in constructing their teacher identity. A mixed-method study from questionnaires and semi-structured interviews was employed to gather quantitative and qualitative data. The participants reported that they faced hard times but displayed high resilient ability. It was influenced by their perseverance, ability to reflect, adaptive help-seeking, responses to the negative affect, and emotional regulation. The resilient ability supports the teacher identity construction after conducting a teaching practicum in school. Further research needs to consider the number of participants, gender, age, and the school levels where the teaching practicums are conducted to gain more perspectives on pre-service teachers’ resilience.</em>
Hydroinformatics opening new horizons: union of computational hydraulics and artificial intelligence
Authors: Babovic V. , Minns A. W. 
Published: December 2022

Abstract
The strengthening dominance of electronics over past several decades has resulted in an almost total dominance of digital representation of the hydro-environment. Recognizing these developments, Mike Abbott introduced the notion of electronic encapsulation of information and knowledge. The act of encapsulating information and knowledge changes the very nature of the information and knowledge involved. Suffice to say that electronic encapsulation must also change the way in which an engineer accesses and uses the available information and knowledge. There is a shift in paradigm away from a model-based approach to a more data-based approach. Adopting such foundational considerations as its core, hydroinformatics opened research to the latest IT developments in the fields of artificial intelligence (including machine learning, evolutionary algorithms and artificial neural networks), artificial life, cellular or finite-state automata and other, previously unrelated sciences and technologies. Through studying and exploiting elements of these, at first sight unrelated, sciences, hydroinformatics produced new and innovative solutions to hydraulic and hydrological problems, as represented by real-time control and diagnosis, real-time forecasting, calibration of numerical models, data analysis and parameter estimation. In particular, the new approaches are able to generate important components of physically based, modelling systems by inducing models or sub-models of individual physical processes based only upon measured data. These (sub)models may then replace whole systems of complex, non-linear, differential equations that would otherwise require great skills from the modeller to calibrate, and powerful computing devices to solve. This chapter captures evolution of data science and AI within the field of hydroinformatics and provides an outline of the present state-of-affairs together with some ideas for future directions. The chapter outlines tangible solutions that have been applied by the hydroinformatics community to address specific challenges in hydro-environmental systems.
Hydroinformatics education at IHE Delft: past and future
Authors: Solomatine D. P. , Price R. K. , Jonoski A. , Popescu I. , Bhattacharya B. , Alfonso Segura L. , Corzo Perez G. , van Andel S. J. , Bertini C. 
Published: December 2022

Abstract
From the very beginning of introducing hydroinformatics as a new discipline of research and practice, Mike Abbott worked together with his collaborators on establishing a supporting educational programme at post-graduate level. This chapter presents the establishment of the first hydroinformatics post-graduate programme at IHE Delft, in the Netherlands, later offered as an MSc degree in water science and engineering with specialization in hydroinformatics. The curriculum and the set-up of the programme are described, together with their developments over the last three decades. This programme has significantly benefited from the unique characteristics of IHE Delft: The institute is specifically oriented to providing water education to participants from the Global South, and, at the same time, it operates within a network of diverse organizations engaged in research and practice of water management in the Netherlands and Europe. The hydroinformatics programme has therefore benefited from contributions of top experts from such institutions who have taken roles as invited lecturers, as well as MSc and PhD mentors and supervisors, very often on water-related topics originating from-, or relevant for students' home countries. Challenges for maintaining relevant attractive hydroinformatics curriculum have come from continuous developments in information and communication technologies (ICTs), need for balancing ICT-related and water-related subjects, while still imparting knowledge regarding the primary role of hydroinformatics as an integrating discipline needed for supporting efficient-, but also transparent and inclusive water-related decision making. The associated PhD programme in hydroinformatics and some related Master programmes at IHE Delft are also briefly introduced. The chapter also presents an overview of hydroinformatics-related education at other universities around the world. The concluding section presents an outlook for future hydroinformatics education in which next to its water and informatics components, its social dimension and integrative purpose will become even more important.
The JAK-STAT Signaling Pathway in Epilepsy
Authors: Sun Huaiyu , Ma Di , Cheng Yu , Li Jiaai , Zhang Wuqiong , Jiang Ting , Li Zhaoran , Li Xuewei , Meng Hongmei 
Published: December 2022

Abstract:
Epilepsy is defined as spontaneous recurrent seizures in the brain. There is increasing evidence
that inflammatory mediators and immune cells are involved in epileptic seizures. As more research
is done on inflammatory factors and immune cells in epilepsy, new targets for the treatment of
epilepsy will be revealed. The Janus kinase-signal transducer and transcriptional activator (JAKSTAT)
signaling pathway is strongly associated with many immune and inflammatory diseases, At
present, more and more studies have found that the JAK-STAT pathway is involved in the development
and development of epilepsy, indicating the JAK-STAT pathway’s potential promise as a target
in epilepsy treatment. In this review, we discuss the composition, activation, and regulation of the
JAK-STAT pathway and the relationship between the JAK-STAT pathway and epilepsy. In addition,
we summarize the common clinical inhibitors of JAK and STAT that we would expect to be used in
epilepsy treatment in the future.
Identification of Novel PPAR-β/δ Agonists from Kaempferol, Quercetin, and Resveratrol Derivatives by Targeting Cancer: An Integrative Molecular
Docking and Dynamics Simulation Approach
Authors: Ballav Sangeeta , Lokhande Kiran Bharat , Sahu Vishal Kumar , Yadav Rohit Singh , Swamy K. Venkateswara , Basu Soumya 
Published: December 2022

Background:
Drug resistance in cancer is a serious threat to human well-being. There is a dire
need to develop novel and efficient lead molecules to treat the disease. In lieu of anti-cancer activities,
Peroxisome proliferator–activated receptors (PPARs)-β/δ proven to be potential therapeutic targets
against cancer. However, there are yet no PPAR-β/δ agonists reported for clinical use.

Objective:
The present study features in silico screening and identification of 8708 derivatives based on
backbone of natural compounds like Kaempferol, Quercetin and Resveratrol against PPAR-β/δ using
molecular docking, and molecular dynamics (MD) simulations.

Methods:
Initial screening of 8708 derivatives was done by recruiting Lipinski’s rule of five. Docking
calculations were assessed through FlexX software tool. GROMACS was used to analyze dynamic perturbations
and binding free energy (MM/GBSA) analysis of the top compounds. SwissADME was used to
analyze pharmacokinetic properties.

Results:
The results of molecular docking indicated that 2-[2-(2,4-Dihydroxyphenyl)-2-
oxoethoxy]benzoate (DOB), (E)-1-(3,4,5-Trihydroxyphenyl)-3-(3,4-dihydroxyphenyl) propene (TDP)
and 2-Hydroxy-3-(2,6,7-trihydroxy-3-oxo-3H-xanthen-9-YL) benzoic acid (HTOB); respective derivatives
of Kaempferol, Resveratrol and Quercetin strongly binds to the active site residues of PPAR-β/δ.
Furthermore, ADME (absorption, distribution, metabolism & excretion) profile conferred their high druglikeness
properties. On monitoring their dynamic perturbations, HTOB acquired the most favorable interaction
and stability within the vicinity of PPAR-β/δ protein.

Conclusion:
These outcomes constitute preliminary studies and the obtained lead derivatives could be
great options to treat various types of cancer and formulate as oral drug candidates.