bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of the “Click Chemistry” Toolbox for the Design, Synthesis, and Resulting Applications of Innovative and Efficient Separative Supports: Time for Assessment
Authors: Le Droumaguet Benjamin , Guerrouache Mohamed , Carbonnier Benjamin 
Published: June 2022

AbstractThe last two decades have seen the rapid expansion of click chemistry methodology in various domains closely related to organic chemistry. It has notably been widely developed in the area of surface chemistry, mainly because of the high‐yielding character of reactions of the “click” type. Especially, this powerful chemical reaction toolbox has been adapted to the preparation of stationary phases from the corresponding chromatographic supports. A plethora of selectors can thus be immobilized on either organic, inorganic, or hybrid stationary phases that can be used in different chromatographic modes. This review first highlights the few different chemical ligation strategies of the “click” type that are up to now mainly devoted to the development of functionalized supports for separation sciences. Then, it gives in a second part an up‐to‐date survey of the different studies dedicated to the preparation of click chemistry‐based chromatographic supports while highlighting the powerful and versatile character of the “click” ligation strategy for the design, synthesis, and developments of more and more complex systems that can find promising applications in the area of analytical sciences, in domains as varied as enantioselective separation, glycomics, proteomics, genomics, metabolomics, etc.
A monoallelic variant in EYA1 is associated with Branchio‐Otic syndrome in a Malian family
Authors: Yalcouyé Abdoulaye , Traoré Oumou , Diarra Salimata , Schrauwen Isabelle , Esoh Kevin , Kadlubowska Magda Kamila , Bharadwaj Thashi , Adadey Samuel Mawuli , Kéita Mohamed , Guinto Cheick O. , Leal Suzanne M. , Landouré Guida , Wonkam Ambroise 
Published: June 2022

AbstractBackgroundBranchio‐otic syndrome (BO) is one of the most common types of syndromic hearing impairment (HI) with an incidence of 1/40,000 globally. It is an autosomal dominant disorder typically characterized by the coexistence of branchial cysts or fistulae, malformations of the external, middle, and inner ears with preauricular pits or tags and a variable degree of HI. Most cases of BO have been reported in populations of European ancestry. To date, only few cases have been reported in people from African descent.MethodsAfter a careful clinical examination, a pure tone audiometry was performed. DNA was extracted from peripheral blood and whole exome, and Sanger sequencing were performed for genetic analysis.ResultsEight individuals from a large non‐consanguineous Malian family, with autosomal dominant inheritance were enrolled. The ages at diagnosis ranged from 8 to 54 years. A high phenotypic variability was noted among the affected individuals. Four patients presented with a post‐lingual and mixed type of HI, one individual had conductive HI while three had normal hearing but presented other BO features namely branchial fistulae and preauricular sinus. Serum creatinine level and renal ultrasonography were normal in three affected individuals who performed them. Genetic testing identified a monoallelic pathogenic variant in EYA1 (c.1286A > G; p.Asp429Gly) segregating with BO syndrome in the family.ConclusionThis is the first genetically confirmed case of BO syndrome caused by EYA1 variant in the sub‐Saharan African population, expanding the genetic spectrum of the condition.
A novel compact asymmetric Doherty PA design using symmetric transistors
Authors: Jin Liwei , Cheng Zhiqun , Wang Yonghui , Liu Guohua 
Published: June 2022

AbstractA novel 7.2 dB output power back off Doherty power amplifier (DPA) based on asymmetrical load is proposed using two same transistors in this paper. To get maximum efficiency at back‐off output power and the largest saturate output power level simultaneously, the carrier power amplifier (PA) is matched to the maximum efficiency region when peaking PA is almost off, and both of the two PAs are matched to maximum power region to get largest output power. According to the proposed design methodology, high efficiency at back‐off power and high peak power DPA is designed and fabricated with two Cree's GaN HEMT CGH40010F devices. Measurements results show that the saturated output power of the DPA is over 44.5 dBm, the drain efficiency when 7.2 dB output power back off and saturate power are above 42% and 53%, respectively, in the range of 3.4–3.8 GHz. Meanwhile, better than −47.8 dBc adjacent channel leak power ratio can be achieved with digital predistortion under 20 MHz LTE signal testing at 3.4 GHz, the final design size is only 14 × 12 cm2.
IGF2R, KCNQ1, PLAGL1, and SNRPN DNA methylation is completed in bovine by the early antral follicle stage
Authors: Lafontaine Simon , Sirard Marc‐André 
Published: June 2022

AbstractImprinted genes are inherited with different DNA methylation patterns depending on the maternal or paternal origin of the allele. In cattle (Bos taurus), abnormal methylation of these genes is linked to the large offspring syndrome, a neonatal overgrowth phenotype analogous to the human Beckwith–Wiedemann syndrome. We hypothesized that in bovine oocytes, some of the methylation patterns on maternally imprinted genes are acquired in the last phase of folliculogenesis. The pyrosequencing analysis of IGF2R, KCNQ1, PLAGL1, and SNRPN imprinted genes showed no clear progression of methylation in oocytes from follicles 1–2 mm (late pre antral/early antral) and up. Instead, these oocytes displayed complete methylation at the imprinted differentially methylated regions (>80%). Other mechanisms related to imprint maintenance should be investigated to explain the hypomethylation at IGF2R, KCNQ1, PLAGL1, and SNRPN maternally imprinted sites observed in some bovine embryos.
Inexact and primal multilevel FETI‐DP methods: a multilevel extension and interplay with BDDC
Authors: Sousedík Bedřich 
Published: June 2022

AbstractWe study a framework that allows to solve the coarse problem in the FETI‐DP method approximately. It is based on the saddle‐point formulation of the FETI‐DP system with a block‐triangular preconditioner. One of the blocks approximates the coarse problem, for which we use the multilevel BDDC method as the main tool. This strategy then naturally leads to a version of multilevel FETI‐DP method, and we show that the spectra of the multilevel FETI‐DP and BDDC preconditioned operators are essentially the same. The theory is illustrated by a set of numerical experiments, and we also present a few experiments when the coarse solve is approximated by algebraic multigrid.
Investigation on insertion mechanism of ultrasound guided insertion process based on numerical simulation
Authors: Cheng Liang , Ji Guobiao , Fei Shaohua , Li Jiangxiong , Ke Yinglin 
Published: June 2022

AbstractThe insertion of finer Z‐pins is the key factor for increasing the reinforcement effects of Z‐pinned composite laminates. This paper presents a three‐dimensional cohesive zone finite element (FE) model for revealing the insertion mechanism of the ultrasound guided insertion process of fine Z‐pins. The prepreg fracture is modeled based on the cohesive elements, where fracture toughness is obtained from the double insertion method. The contact between the needle and prepreg is simulated by LuGre dynamic friction model. According to model simulation and relevant experiments, compared with nonvibratory insertion, smaller insertion force, earlier surface fracture and slighter ply crimp can be observed in the ultrasound guided insertion process. In addition, the prepreg forms an initial crack firstly after needle insertion, followed by a final crack due to needle extraction and prepreg springback. The effects of needle diameter on the insertion force and crack length are discussed. It can be concluded that larger needle diameter can lead to greater insertion force and initial crack length, but has little effect on the final crack length.
Nanofiber‐Carbon black dual filler reinforced sustainable high‐performance Natural Rubber nanocomposites
Authors: Surya Koodappuzha Parameswaran , Naskar Kinsuk , Bhowmick Anil K. 
Published: June 2022

AbstractIn the present work, uncured and cured properties of high‐performance, sustainable Natural Rubber nanocomposites developed by leveraging the unique synergy between carbon black and fibrous nanofillers such as silicon carbide, carbon nanotubes, and aramid nanofibers were investigated. Reinforcement in these composites was analyzed using the properties of the unvulcanized compounds, which were then correlated with those of the vulcanized compounds. A 50% increment was recorded for the bound rubber content of the nanocomposites, which resulted in tremendous improvements in the reinforcement index and tensile strength of the unvulcanized nanocomposites. In contrast, the die swell index came down compared with the control compound. The formation of a percolating network due to the presence of high aspect ratio fibers resulted in a higher Payne effect in hybrid nanocomposites, which was confirmed from the scanning and transmission electron microscopy. The 100% modulus, 300% modulus, and tensile strength of the unvulcanized nanocomposites recorded an improvement of 80, 121, and 450%, respectively, by the incorporation of nanofibers. The molecular aspects of reinforcement were elucidated from theoretical calculations using Mooney–Rivlin plots. It was presumed that the improved reinforcing efficiency of the nanofibers resulted from restricted mobility of elastomer chains due to the presence of the dual filler system.
A computational study for the reaction mechanism of AIBN‐induced remote trifluoromethyl‐alkynylation of thioalkynes
Authors: Fıstıkçı Meryem 
Published: June 2022

AbstractA computational study for 2,2‐azobis (isobutyronitrile) (AIBN)‐induced remote trifluoromethyl‐alkynylation of thioalkynes is carried out employing the density functional theory (DFT). According to our computations, the decomposition of AIBN, which is the initial step of the radicalic reaction, include the highest reaction energy step and indicate that the rate‐determining step is the decomposition of AIBN for the reaction scheme. Our computations show that the reaction can also proceed through the vinyl radicals 12 and 18 as well as the vinyl radicals 3 and 10 suggested by Zhu and co‐workers. The computations are compatible with experimental data. Moreover, our computations provide useful insight into the radicalic mechanism of AIBN‐induced remote trifluoromethyl‐alkynylation of thioalkynes.
Nonobstetric surgery during pregnancy in Finland during a 21‐year period: A register‐based study
Authors: Haataja Anna , Gissler Mika , Kokki Hannu , Heino Anna , Järvelin Jutta , Porela‐Tiihonen Susanna , Kokki Merja 
Published: June 2022

AbstractObjectiveTo assess how much and on which specialities nonobstetric surgery was performed for pregnant women in Finland during a 21‐year period, between 1997 and 2017 and the effect of Finnish guideline about preoperative evaluation affected the amount of surgery during pregnancy.DesignRegister‐based observational study.SettingFinnish Medical Birth Register.Population1 175 677 pregnancies ending with a singleton birth 1997−2017.MethodsAmount of nonobstetric surgeries, and pregnancy foetal and maternal outcomes in Finland between 1997 and 2017 were searched.Main Outcome MeasuresThe prevalence of nonobstetric surgery, and proportions of elective and emergency nonobstetric surgery performed during the three trimesters.ResultsThe prevalence of nonobstetric surgery before the guideline was 0.39%, after the guideline 0.28% and after the first revision 0.39%. The prevalence of elective surgery decreased after the guideline (before 0.15%, after the guideline 0.10% and 0.07% after the first revision), but the prevalence of emergency surgery was highest after the first revision (0.24%, 0.21% and 0.29%). The guideline and the first revision had no impact on the timing of elective surgery; 35% of elective surgery was performed during the second trimester before the guideline, 36% after it and 36% after its first revision. The preterm delivery rate, 9.1%−9.4% of pregnancies with nonobstetric surgery was twofold higher than that of pregnancies without surgery.ConclusionThe prevalence of nonobstetric surgery during pregnancy is low in Finland. The national guideline decreases the prevalence of elective surgery during pregnancy but does not impact the timing of nonobstetric surgery.
Quantifying the in‐channel contribution to suspended‐sediment concentration, a concept for sediment yield apportionment using limited data
Authors: Khettab Omar El Farouk 
Published: June 2022

AbstractRecently, the focus on sediment source assessment has increased because of the importance it has in prioritizing management strategies to limit soil loss, water quality deterioration, and aquatic ecosystems degradation. In this work, a rapid integration technique is proposed to separate the sediment yield portion detached from the stream channel by water erosion and the portion supplied from the watershed or stored within the channel. The concept of the lower bound curve was established based on hysteresis analysis fundamentals. On this basis, a straightforward calculation technique was designed. The lower bound curve simplifies the estimation of sediment sources' contributions using continuous concentration‐discharge measurements. The method was tested using flood events from six United States Geological Survey stations. According to hysteresis analysis fundamentals, the method was validated relying on successive and multipeak events and sediment depletion as an indicator. The analysis of successive floods showed consistent sediment depletion criteria, indicating that the lower bound curve corresponds to the stream contribution. Consequently, the method can successfully separate and quantify the contribution of the stream channel to suspended sediment yield. Minor events were found to be unable to reach sediment depletion. However, proceeding with multi‐peak events solved this issue, which improved the sediment yield estimations compared to single‐peak processing.
Desulfurization‐Induced Formation of Amorphized Substoichiometric Tin Sulfide for Super High‐Rate Capacity and Degradation‐Free Cycling of Na Ion Storage
Authors: Xiang Jing , Jiang Zhong‐Jie , Wang Yongjie , Jiang Zhongqing 
Published: June 2022

AbstractThis work reports an amorphization and partial desulfurization method to improve the performance of sulfide‐based materials for Na+ storage. Specifically, the polypyrrole derived carbon coated amorphous substoichiometric tin sulfide supported on aminated carbon nanotubes (PPY‐C@SnSx/ACNTs) with amorphized and substoichiometric tin sulfide (SnSx) is synthesized by simply thermal annealing the PPY‐C@SnS2/ACNTs. The PPY‐C@SnSx/ACNTs shows stable reversible capacities of 410.2 mAh g−1 for Na+ storage at 0.1 A g−1 and excellent rate capacities of 270.2, 235.5, 217.4, and 210.0 mAh g−1 at 5.0, 10.0, 20.0, and 30.0 A g−1, respectively. Nearly zero drops on the reversible capacities can be observed when it is sodiated/desodiated at 2.0, 5.0, and 10.0 A g−1 for up to 1000, 6500, 8000 cycles, respectively. Its outstanding rate capacities and degradation‐free cycling stabilities mainly arise from the amorphized and substoichiometric structure of SnSx, which improve the reversible capacities and Na+ diffusivities of the PPY‐C@SnSx/ACNTs. The density functional theory (DFT) calculations indicate that the partial desulfurization can improve the electric conductivity and promote the sodiation/desodiation of SnSx. It explains why the PPY‐C@SnSx/ACNTs can exhibit high performance for Na+ storage well.
Method to integrate asynchronously produced individual influence maps into an extrapolated population influence map following the face‐to‐face stage of a structured democratic dialogue
Authors: Laouris Yiannis 
Published: June 2022

AbstractWe present a method that broadens the application of structured democratic dialogue (SDD). After completing the final stage of the SDD process, during which the participants explore collectively and synchronously possible influence relations between ideas using the interpretive structural modelling (ISM) algorithm, they continue the ISM process individually and asynchronously. Their respective adjacency matrices (AM) are integrated into a population AM (pAM) that reflects their least agreement denominator. The pAM is sent back to them in a few iterations, asking them to explore influence relations between additional ideas. This procedure eventually produces a model, which depicts their ‘extrapolated’ or ‘computed’ collective wisdom. The method has been applied in two projects. Participants who responded to a requested assessment (via a Likert scale) indicated that the extrapolated influence maps created asynchronously made sense.
Performance‐based design method for isolated hollow RC piers with irregularity in height
Authors: Rasouli Mahsa , Shiravand Mahmoud R. , Rasti Ardakani Reza 
Published: June 2022

AbstractThe bridge piers are the main components, and their destruction can cause significant damage to bridges. The concentration of failure in one or two piers of irregular bridges has led to challenges in codes and studies regarding the simultaneous failure of the substructure components. The RC hollow sections are structurally adequate for application in isolated bridges with unequal pier heights due to their large strength/mass and stiffness/mass ratios. In the previous studies, the isolation devices have been used to produce uniform lateral stiffness for different pier‐isolator systems of bridges with unequal pier heights. However, this approach leads to the flexural moment concentration in the tall piers and extra ductility demand in the short‐pier isolators. This article presents a new performance‐based design method for isolated hollow RC piers with irregularity in height to provide uniform performance along the bridge. The target performance level is achieved by proper selection of the characteristics of LRBs and pier cross‐sections. This method is used for two continuous span bridges with slight and severe irregularities, and the responses are compared with other design methods. The results show that the proposed method produces similar performance levels in all piers, besides uniform ductility demand, uniform shear strain, and simultaneous failure of all LRBs. Furthermore, the damage probability of tall piers decreases and gets close to that of the short ones.
Basalt fiber reinforced foam concrete with marble waste and calcium aluminate cement
Authors: Bayraktar Oguzhan Yavuz , Yarar Gokhan , Benli Ahmet , Kaplan Gokhan , Gencel Osman , Sutcu Mucahit , Kozłowski Marcin , Kadela Marta 
Published: June 2022

AbstractAs a typical cellular lightweight material, foam concrete is produced by mixing cement, water, aggregate and a suitable foaming agent and has a density usually below 1600 kg/m3. The large number of air spaces present in foam concrete ensures that the concrete has advantages such as lightweight, high fluidity during pouring, excellent thermal and sound insulation, superior fire resistance, and outstanding energy absorption capacity. Its high porosity and the connectivity of the pores, which can allow the entry of negative substances into the concrete environment, cause foam concrete to have a very low physico‐mechanical and durability performance. To eliminate or reduce these disadvantages, this study adopted the use of basalt fibers (BF) as eco‐friendly fiber type and calcium aluminate cement (CAC) as aluminous cement with waste marble powder (WMP) as aggregates in foam concrete. In that respect, 9 mixes with varying content of foaming agent (FC) and basalt fiber have been prepared. Assessment of mechanical performance was based on compressive and flexural strength after 6 h, 1, 7, and 28 days. Dry bulk density, thermal conductivity, porosity, water absorption, and sorptivity of the concretes were determined. Durability characteristics of the concretes were examined by dry shrinkage, high temperature, magnesium sulfate, sulfuric, and hydrochloric acids. The obtained results showed that the content of BF affected the compressive strength of the mixtures slightly negatively or positively depending on the FC. The lowest value in thermal conductivity was gained as 0.645 (W/m K) for the mixture incorporating 1% BF and 50 kg/m3 foam quantity. In addition, the foam concrete incorporating foam of 30 kg/m3 and 1% BF showed the best resistance against MgSO4. The mixture with 2% BF and 30 kg/m3 FC exhibited the lowest mass loss after HCI exposure.
Read‐Alouds: A Case Study of Two Preschoolers on the Autism Spectrum
Authors: Riojas‐Cortez Mari , Martinez Miriam 
Published: June 2022

AbstractThis study examines the types of interactions and early literacy development that occur when non‐verbal 4‐year‐old children on the autism spectrum engage with family members in read‐alouds using authentic children's literature. Findings indicate the importance of quality children's literature for read‐alouds. A key implication of the study is that teachers of young children with autism need to form partnerships with family members to encourage them to engage with their children in authentic read‐alouds.
Idiopathic generalised tremor syndrome in dogs
Authors: Phillipps Stephanie , DeDecker Steven , Gutierrez‐Quintana Rodrigo , Alcoverro Emili , Gomes Sergio A , Goncalves Rita 
Published: June 2022

ABSTRACTBackgroundIdiopathic generalised tremor syndrome (IGTS) causes tremor and often vestibulocerebellar signs. Previous publications on IGTS in dogs are restricted to case reports or lack exclusion of structural causes.MethodsMedical records of 75 dogs diagnosed with IGTS that had undergone magnetic resonance imaging (MRI) of the brain were collected retrospectively.ResultsCrossbreeds were affected most commonly (41.3%), followed by West Highland white terriers (14.7%) and cocker spaniels (10.7%). A higher proportion of females were affected than males (68.0%). Median age of the affected dogs was 17 months (range 6–121 months), and median bodyweight was 9.15 kg (range 2.9–26 kg). All dogs presented with tremors and most experienced concomitant neurological signs (93.3%). Seventeen (22.7%) were hyperthermic and 31 (41.3%) had gastrointestinal signs. MRI of the brain was normal in most of the cases, and cerebrospinal fluid analysis frequently revealed mild pleocytosis. All animals were treated with prednisolone, and 39 (51.3%) also received diazepam. Median follow‐up time was 13 months (range 0–134 months). The overall outcome was good, although 16 (21.3%) patients were reported to have relapsing clinical signs and 10 (13.2%) patients experienced persistent mild clinical signs.ConclusionsIGTS should be suspected in any dog with generalised tremor and vestibulocerebellar signs with younger and smaller dogs more commonly affected.