bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERFIL EPIDEMIOLÓGICO DA GRAVIDEZ NA ADOLESCÊNCIA NAS MICRORREGIÕES DO ESTADO DO TOCANTINS DURANTE OS ANOS DE 2008 - 2018
Authors: Silingowschi de Oliveira Esther , Jardim Gomes Camila , Pereira Parreira Artur , De Jesus Pinheiro Maria Lara , Ramos Oliveira Kaio , Cândida de Queiroz Santos Anjos Fabiana , Ferreira Barbosa Priscila 
Published: August 2022

O Tocantins apresenta população total de aproximadamente 1.383.445 habitantes sendo cerca de 10% são adolescentes do sexo feminino, nesse sentido, uma atenção deve ser voltada a essa classe já que nos últimos anos tem se observado os crescimentos na quantidade de meninas que se tornam mães durante essa fase. O objetivo do trabalho foi expor os números e sugerir quais fatores podem estar relacionados com a gravidez na adolescência. Os dados foram retirados do SINASC, no período de 2008 a 2018. Foi encontrado que dos 272983 nascidos vivos, 64.623 eram filhos de mães adolescentes. Foi exposto que uma defasagem na formação educacional pode estar relacionada com esse índice elevado, evidenciou-se também um maior número de partos vaginais bem como reduzidas consultas pré-natais nas microrregiões com serviço público de saúde deficitário, com destaque para o Jalapão. É recomendado um investimento na atenção básica, principalmente nas microrregiões mais afetadas e na oferta não apenas de recursos, mas de atenção especial e estruturada, proporcionando melhor acesso à informação e instrução das adolescentes.
COMPARAÇÃO FARMACOECONÔMICA ENTRE MEDICAMENTOS E FITOTERÁPICOS UTILIZADOS NO TRATAMENTO DA DEPRESSÃO
Authors: Da Silva Marinho Larissa Caroline , Lameira da Silva Rhaissa Calazans , Nobre Lima do Nascimento Guilherme 
Published: August 2022

A depressão é um transtorno mental caracterizado por tristeza, perda de interesse e baixa autoestima, entre outros. Dentre os tratamentos de escolha, têm-se as psicoterapias, os antidepressivos (medicamentos sintéticos) e as plantas medicinais - fitoterapia. Estima-se que a depressão e a ansiedade sejam responsáveis por uma perda anual de produtividade de mais de um trilhão de dólares. Ao se tratar de estudos de custo-efetividade para determinar qual seria a melhor medicação de referência de tratamento para a depressão, observa-se estudos escassos ou inexistentes na maioria dos países. Deste modo, o presente estudo busca comparar os medicamentos antidepressivos com os fitoterápicos usados no tratamento da depressão com relação ao custo-benefício dos mesmos, expondo também a acareação dos efeitos colaterais de cada um, nos municípios de Palmas, Araguaína e Gurupi do Estado do Tocantins. A análise de custo-benefício foi avaliada considerando o custo médio da medicação por dia de tratamento e menor quantidade de efeitos colaterais, e foi realizada a comparação de preços entre a aquisição de medicamentos em drogarias ou em farmácias e comparação de preços entre as cidades do estudo.
Pelatihan Desain dan Pemodelan Bangunan Menggunakan Program SAP 2000 di Jurusan Desain Pemodelan Informasi Bangunan (DPIB) SMK PGRI 1 Gresik
Authors: Irsyadi Rezky Setya , Hidayat Hidayat 
Published: August 2022

Dalam upaya menjaga mutu pendidikan terhadap pengaruh perkembangan teknologi informasi yang terdapat pada kurikulum SMK jurusan Desain Pemodelan Informasi Bangunan (DPIB) mata pelajaran struktur bangunan, maka perlu dikenalkan kepada peserta didik bahwasanya terdapat program komputer yang dapat menunjang mata pelajaran tersebut. Program komputer tersebut adalah SAP 2000 yang dapat digunakan untuk menganalisis gaya – gaya yang bekerja pada struktur balok, kolom, pelat, dan penampang konstruksi rumah 2 lantai. Sebagai bentuk upaya yang dapat dilakukan untuk menjaga mutu pendidikan terhadap pengaruh perkembangan teknologi informasi yang terdapat pada kurikulum SMK jurusan Desain Pemodelan Informasi Bangunan (DPIB) mata pelajaran struktur bangunan, maka perlu dilakukan sebuah usulan untuk mengadakan kegiatan ” Pelatihan Desain dan Pemodelan Bangunan Rumah 2 Lantai Mengguanakan Program SAP 2000 Di Jurusan Desain dan Pemodelan Infomasi Bangunan (DPIB) SMK PGRI 1 Gresik”. Di akhir kegiatan, peserta diminta untuk menilai atau mengisi pertanyaan yang berkaitan dengan 8 komponen penilaian yang sudah disebutkan pada bab pembahasan. Secara keseluruhan hasil yang didapat adalah para peserta memilih atau menilai pada angka 3, 4, dan 5. Yang artinya bahwa kegiatan ini masih bisa diterima layak berdasarkan 8 komponen penilaian tersebut dan tujuan pembelajaran pada pelatihan ini di nilai tercapai
Linking sediment flux to river migration in arid landscapes through mass balance
Authors: Ielpi Alessandro , Lapôtre Mathieu G.A. 
Published: August 2022

ABSTRACT
Lateral migration is a key process shaping sinuous rivers and controlling sediment exchange with floodplains. The rate at which channels migrate is affected by bend curvature, bank erodibility, and sediment supply. The relationship between migration rate and sediment supply is poorly understood in dryland regions, where direct measurements are scarce. Here we propose a simple mass-balance model to estimate the sediment flux of ephemeral streams in North America's Great Basin and establish a comparison with timelapse photogrammetric data of lateral migration. The model takes into consideration variables such as long-term hillslope erosion, transient sediment storage in intra-catchment lowlands, and sediment bypass to depocenters. Our results point to first-order similarities in how sediment supply drives channel migration across diverse hydro-climatic regimes. However, we find that, for a given sediment supply and channel width, and despite their ephemeral discharge, dryland streams with minimal bank vegetation migrate about three times faster than humid-climate, vegetated ones. This difference in migration pace likely results from the compound effect of bank erodibility and bend geometry. Our model sheds new light on the driving mechanisms of channel mobility in dryland streams and may find application in assessing the sediment budgets of ungauged streams, reservoir trapping, and morphodynamic adjustments in stressed watersheds.
In-Situ Combustion: Myths and Facts
Authors: Sur Sidhartha 
Published: August 2022

Summary
In-situ combustion (ISC) involves compression and injection of air into heavy/extraheavy oil reservoirs for enhancing production and recovery. Initially, ISC was very popular due to its high theoretical thermal efficiency, though more failures than successes in the 1990s made this process unpopular. It is a fact that it is now widely considered archaic. However, Suplacu de Barcau (Romania) and Balol-Santhal (India) ISC projects have brought the process back into focus. Performance of the Balol-Santhal-Bechraji over the last 25 years provides clarity to answer the question “Failure to enhance oil production and recovery by ISC: Myth or fact?” The author appreciates the views, decisions, and efforts of all global scientists/engineers/operators associated with the ISC process in the laboratory/field. Opinions and views presented in this paper are solely based on the author’s experience, which may be in line or may differ.
The discovery of heavy oil northwest of the Cambay Basin, India, in the 1970s led to the initiation of research and development in thermal processes. The depth, rock, and fluid characteristics, drive mechanism, and semi-arid area led to the testing of ISC over steamflood in Balol. Laboratory findings are key to understanding the reaction kinetics of oil and process manifestations. Upgrading of oil is the key manifestation of ISC in the laboratory, but it is not seen in the field due to blending in long-distance displacement methodology. The involvement of laboratory personnel in design and surveillance plays an important role in the success of the project. Over the last 25 years, the Balol-Santhal ISC projects demonstrate the rejuvenation of declining fields with sustained enhanced oil production and an increase in recovery. Lessons of the Bechraji field indicate that process does not succeed in all reservoir settings. It is particularly suited to relatively clean, mobile heavy oil reservoirs with structural relief. Long-distance displacement of oil (vertical injector-vertical/horizontal producer spaced apart) is effective in a mobile oil reservoir. With low mobility oils, a short-distance oil displacement process using a pair of vertical injector and horizontal producer (horizontal well placed below the air injector) can be the preferred way for exploitation. This methodology has also the potential to capture upgraded oil. The process attracts more value when it is designed as operator friendly and flexible, integrating with gravity. Appropriate ignition types, continuous surveillance, maintaining optimum air injection rates, and re-engineering are important for the success of ISC. Success depends on the fabric and architecture of the reservoir, the way it is designed and implemented, and by integration of knowledge gained in the journey from laboratory to field with the process. It can be concluded that the perception of the ineffectiveness of ISC to enhance oil production and recovery from mobile heavy/extraheavy oil reservoirs cannot be generalized as a fact.
iEngage: a digital health education program designed to enhance physical activity in young adolescents
Authors: CAILLAUD Corinne , LEDGER Susan , Diaz Claudio , CLERC Gael , GALY Olivier , YACEF Kalina 
Published: August 2022

Abstract

iEngage is a modular health education and behavioural change program designed to help adolescents increase moderate to vigorous physical activity (MVPA). The program is delivered through the iEngage app which integrates activity trackers data (Misfit Ray©) within 10 interactive learning modules. Key features include guidance to set goals, self-monitor and assess achievements, and experiential learning via the connected activity trackers which allows for continuous steps recording during the program. iEngage was implemented in two schools over 5 weeks with 10-12 years old adolescents (n = 57) and PA outcomes compared to control group (n=26). Results show that adolescents successfully set goals and self-assessed achievements during the program, progressing toward higher physical activity (PA) levels as shown by the increase in daily steps through the program (+30%, + 2647 steps/day, P < .001) with boys increasing goals and achievements faster than girls. The consistency in days totalling at least 11,000 steps/day increased from 35% at the start to 48% at the end of the program. The increase in PA is confirmed through the assessment of MVPA during schooldays pre- and post- program via research grade wrist accelerometers in iEngage and in control participants. Contrasting with the control group, MVPA was increased in the week following the program (~+5 min/day, P = .023) in short bouts, particularly during lunch time, recess and after school. This study shows that a digital program integrating activity trackers and combining health education, goals setting and self-monitoring of PA, helped young adolescents enhance PA goals, improve achievements and increase MVPA.
Can probiotics modulate the cytokines and antibodies levels in food allergy models? A meta-analysis.
Authors: Sariego Taimy Hernández , Toro Daylin Domínguez del , Barranco Jesús Junco , Arenal Amilcar 
Published: August 2022

Abstract
Background
Food allergy has emerged as a significant medical problem in the last decades. Probiotics' effects on food allergies have brought contradictory results. The present study aimed to assess the probiotic's results in cytokines related to food allergy through meta-analysis.
Methods
Science Direct and Scopus search engines were searched for relevant studies published from 2008 to 2019 without language exclusion. Some experiments were selected from articles evaluating the effect of probiotics on food allergy through pre-clinical studies, with the results published in peer-reviewed journals, with any dispersion measure. Cytokines values were selected as outcomes. We used metaregression to study the probiotic effect in each cytokine and the influence of some experimental design factors.
Results
We obtained a total of 13 studies that met the criteria for the meta-analysis. Probiotics download the regulation of IL-4 and IgE and the upload regulation in IL-6 and TGF-β compared to controls. Lactobacillus is a species that helps in the restoration of IL-4 levels. Animal age, probiotic concentration, and microorganism specie affect the probiotic effect in INF-γ.
Conclusion
The meta-analysis evidenced, in pre-clinical studies, the effects of probiotics on cytokines related to food allergy.
Biocontrol Potential of Bacillus velezensis wr8 secondary metabolites against Penicillium sp.
Authors: Wang Rui , Wang Xiaohu , Weng Yuting , Lan Baofeng , Zhou Liqin , Yang Hui 
Published: August 2022

Abstract

Blue mold caused by Penicillium sp. is one of the most serious postharvest diseases of citrus fruit. The aim of this study was to isolate and identify native Bacillus with inhibition phenotypes of citrus plants fruits. We investigated the antifungal effect of Bacillus velezensis wr8 on the postharvest pathogens Penicillium sp. inoculated on fruits, as well as on the growth of these fungi on Petri dishes with defined media. MALDI-TOF MS was conducted to illuminate the underlying mechanism. Results showed that Bacillus velezensis wr8 significantly inhibited Penicillium sp. growth in vitro. Moreover, secondary metabolites suppressed the disease development of citrus fruits artificially inoculated with Penicillium sp. in 25℃. Furthermore, MALDI-TOF MS indicated that lipoprotein with the molecular mass of 30.2 kDa was a key component about against Penicillium sp.. In addition, the secondary metabolites with antibacterial activity against Escherichia coli showed antimicrobial peptide with the molecular weight of 9.8 kDa. These results demonstrated that Bacillus velezensis wr8 could produce lipoprotein and antimicrobial peptide to inhibit Penicillium sp. and Escherichia coli which has broad application prospect in the future development. Finally, Bacillus velezensis wr8 is to provide data support for the development and utilization of high activity bacteriocin at room temperature and its application in the field of food safety.
Constructing Ti3C2Tx/Carbon Fiber hybrids for enhancing the interfacial strength and erosion wear resistance of EP based composite coating
Authors: Chen Yufan , Wu Yinghao , Zhao Wenjie 
Published: August 2022

Abstract
The composite coatings are indispensable for protecting the offshore steel structures serviced in the splash zone. But the mechanical properties of conventional epoxy resin (EP) coatings are poor, which would lead to the short-term lifespan. The carbon fiber (CF) with excellent mechanical properties is an ideal filler to reinforce the EP coating, thus we chemically grafted Ti3C2Tx nanosheets onto CF via dopamine to enhance the compatibility between CF and EP. While improving the interface adhesion between CF and EP, the mechanical strength and erosion wear resistance of the CF/Ti3C2Tx@EP coating were also significantly enhanced. The flexural properties of CF/Ti3C2Tx@EP composite coating was evaluated by three-point bending test, and the flexural strength of CF/Ti3C2Tx@EP was increased by 41.95% compared with pure EP coating. The tribological behaviors and erosion wear resistance of those composite coatings were carried out by UMT-3 tribometer and erosion test rig. Comparing with the pure EP coating, the wear rate of CF/Ti3C2Tx@EP was decreased by 43.67%, and the erosion mass and volume of CF/Ti3C2Tx@EP were respectively reduced by 21.31% and 44.50%, this were ascribed to the increased interfacial combination strength between the Ti3C2Tx/CF hybrids and EP matrix. We investigated the failure behavior and revealed the interfacial strengthening mechanism of the CF/Ti3C2Tx@EP composite coating, which would evoke widespread interest in developing high performance and long-term protective composite coatings used in the splash zone of marine environment.
Induced pluripotent stem cell-derived dendritic cell vaccine therapy genetically modified on the ubiquitin-proteasome system
Authors: Tominaga Shinta , Ojima Toshiyasu , Miyazawa Motoki , Iwamoto Hiromitsu , Kitadani Junya , Maruoka Shimpei , Hayata Keiji , Yamaue Hiroki 
Published: August 2022

Abstract
We previously reported that dendritic cells (DCs) transduced with the full-length tumor-associated antigen (TAA) gene induced TAA-specific cytotoxic T lymphocytes (CTLs) to elicit antitumor responses. To overcome the issue of quantity and quality of DCs required for DC vaccine therapy, we focused on induced pluripotent stem cells (iPSCs) as a new tool for obtaining DCs and reported efficacy of iPSCs-derived DCs (iPSDCs). However, in clinical application of iPSDC vaccine therapy, further enhancement of the antitumor effect is necessary. In this study, we targeted mesothelin (MSLN) as a potentially useful TAA, and focused on the ubiquitin-proteasome system to enhance antigen-presenting ability of iPSDCs. The CTLs induced by iPSDCs transduced with MSLN gene (iPSDCs-MSLN) from healthy donors showed cytotoxic activity against autologous lymphoblastoid cells (LCLs) expressing MSLN (LCLs-MSLN). The CTLs induced by iPSDCs transduced ubiquitin-MSLN fusion gene exhibited higher cytotoxic activity against LCLs-MSLN than the CTLs induced by iPSDCs-MSLN. The current study was designed that peripheral T-cell tolerance to MSLN could be overcome by the immunization of genetically modified iPSDCs simultaneously expressing ubiquitin and MSLN, leading to a strong cytotoxicity against tumors endogenously expressing MSLN. Therefore, this strategy may be promising for clinical application as an effective cancer vaccine therapy.
Machine Learning Model Identifies Genomic Variation in Noise-Induced Hearing Loss via Whole-exome Sequencing
Authors: Fan Boya , Wang Gang , Han Haolun , Li Baowei , Wang Lei , Qu Changbei , Zhang Xiaoli , Liu Hongdan , Sun Zhezhe , Zhou Ying , Zhang Yiyan , Wu Wei 
Published: August 2022

Abstract
Noise-induced hearing loss (NIHL) is related to noise exposure and whether humans suffered from NIHL is also related to different sensitivity to noise. Whole exome sequencing (WES) can detect the genetic mutations of NIHL population so as to find the susceptibility of different people from the genetic level. WES can identify contributing genes, not only find NIHL susceptibility genes, but also divide patient cohort into different subtypes. We conducted a case-control (n = 78, n = 35, respectively) study to find the susceptibility genes of NIHL through WES and stratified the cases into subtypes, so as to achieve the purpose of precision medicine. 73 gene variants were used to train the unsupervised machine learning model which separated the case from the control group and divide the population into two subtypes. Supervised machine learning methods compared the above constructed subgroup classification models. This is the first study to link NIHL with gene variants and has produced a new potential classification method that can be applied to precision medicine in people’s different sensitivity to noise. These observations deserve further study on independent and larger clinical samples in order to provide new information for future research on the susceptibility of NIHL.
Identification of transcriptomics biomarker for the early prediction of critically ill COVID-19 patients
Authors: Chen Yong , zhang Wenbo , Yu Yonglin , Chen Xiaoju , Jiang Guolu , Ou Guochun , Liu Qin , Jiang Li , Chen Jianjun 
Published: August 2022

Abstract
Objective
Identifying the biological subsets of severe COVID-19 could provide a basis for finding biomarkers for the early prediction of the prognosis of severe COVID-19 and poor prognosis, and may facilitate specific treatment for COVID-19.
Methods
In this study we downloaded microarray dataset GSE172114 from the Gene Expression Omnibus (GEO) database in NCBI, and screened differentially-expressed genes (DEGs) by using the limma package in R software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted, and the results were presented by volcano, Venn, heat, and enrichment pathway bubble maps in the R language package. Gene set enrichment analysis (GSEA) was used to explore and demonstrate the signal pathways related to severe COVID-19. Protein-Protein Interaction (PPI) Network analysis and visualization were performed by using STRING and Cytoscape. Seven key protein expression molecules were screened by the MOCDE plug-in. Then, the cytoHubba plug-in was used to screen 10 candidate genes with maximal clique centrality (MCC) algorithm as the standard, and the intersection with the Venn diagram was used to obtain seven Hub genes. Receiver operating characteristic (ROC) curves were drawn to determine the area under the curve (AUC), and the predictive value of the key genes was evaluated.
Results
A total of 210 DEGs were identified, including 186 upregulated genes as well as downregulated ones. GO enrichment and KEGG pathway analysis were used, and the results were presented by volcano, Venn, heat, and enrichment pathway bubble maps in the R language package. Gene set enrichment analysis (GSEA) was used to explore and demonstrate the signal pathways related to severe COVID-19. Protein interaction network (PPI) analysis and visualization were performed by using STRING and Cytoscape. Seven key protein expression molecules were screened by the MOCDE plug-in. Then, the cytoHubba plug-in was used to screen 10 candidate genes with maximal clique centrality (MCC) algorithm as the standard, and the intersection with the Venn diagram was used to obtain seven Hub genes. Receiver operating characteristic (ROC) curves were drawn to determine the area under the curve (AUC), and the predictive value of the key genes was evaluated. The AUC of the PLSCR1 gene was 0.879, which was the most significantly upregulated key gene in critically ill COVID-19 patients.
Conclusions
Based on bioinformatics analysis, we found that the screened candidate gene, PLSCR1, may be closely related to the occurrence of severe COVID-19, and can thus be used for the early prediction of patients with severe COVID-19, and may provide meaningful research direction for their treatment.
Statistical evaluation of rainfall time series in concurrence with groundwater resources of Bhandara District, Central India
Authors: Kudnar Nanabhau S. , Kushwaha Nand Lal , Rajashekhar Madiga , Mishra Varun Narayan , Mahesh Rongali , Jatav Malkhan Singh 
Published: August 2022

Abstract
The present study investigates the trend and spatial distribution of rainfall, and groundwater quality assessment for sustainable management of available water resources in the Bhandara district, Maharastra, India. To assess the rainfall trend, parametric and non-parametric statistical techniques (Mann-Kendall test statistic, Sens’s slope estimator) were applied in collected rainfall data from seven gauging stations. The yearly rainfall over the study area reveals substantial decreases during the past 43 years (1971-2013). The trend analysis results showed negative trends in Bhandara, Lakhani, Mohadi, and Pawani, Lakhandur, and Tumsar and positive trendobservedin Sakoli station. However, increased rate of Sakoli station is little about 0.84mm/ year. Among all the stations, Bhandara station experiencing rapidly decreasing rainfall trend. Water samples were analyzed for various parameters such as TSS, TDS, pH, Total Alkalinity etc., andFrom Piper analysis, most of the groundwater samples are concentrated in the Na–Cl type, with minor representations from mixed Ca–Na–HCO3 types. 62.5% of samples influenced by Sea water intrusion. Other 37.5 % representing their groundwater contaminated by Alkaline deposits. About 62.5% of samples having more than the maximum permissible limits of Nitrate in their water content according to the IS:10500. Few parts of study area consist very high saline ground water which is not suitable for irrigation purpose also. The nature of rainfall trends and distribution and groundwater analysis in this district can be useful for other departments or districts.