bluuebunny/crossref_metadata_2025_split huggingface dataset:
EDomics: a comprehensive and comparative multi-omics database for animal evo-devo
Authors: Wei Jiankai , Liu Penghui , Liu Fuyun , Jiang An , Qiao Jinghan , Pu Zhongqi , Wang Bingrou , Zhang Jin , Jia Dongning , Li Yuli , Wang Shi , Dong Bo 
Published: November 2022

Abstract
Evolutionary developmental biology (evo-devo) has been among the most fascinating interdisciplinary fields for decades, which aims to elucidate the origin and evolution of diverse developmental processes. The rapid accumulation of omics data provides unprecedented opportunities to answer many interesting but unresolved evo-devo questions. However, the access and utilization of these resources are hindered by challenges particularly in non-model animals. Here, we establish a comparative multi-omics database for animal evo-devo (EDomics, http://edomics.qnlm.ac) containing comprehensive genomes, bulk transcriptomes, and single-cell data across 40 representative species, many of which are generally used as model organisms for animal evo-devo study. EDomics provides a systematic view of genomic/transcriptomic information from various aspects, including genome assembly statistics, gene features and families, transcription factors, transposable elements, and gene expressional profiles/networks. It also exhibits spatiotemporal gene expression profiles at a single-cell level, such as cell atlas, cell markers, and spatial-map information. Moreover, EDomics provides highly valuable, customized datasets/resources for evo-devo research, including gene family expansion/contraction, inferred core gene repertoires, macrosynteny analysis for karyotype evolution, and cell type evolution analysis. EDomics presents a comprehensive and comparative multi-omics platform for animal evo-devo community to decipher the whole history of developmental evolution across the tree of life.
CRdb: a comprehensive resource for deciphering chromatin regulators in human
Authors: Zhang Yimeng , Zhang Yuexin , Song Chao , Zhao Xilong , Ai Bo , Wang Yuezhu , Zhou Liwei , Zhu Jiang , Feng Chenchen , Xu Liyan , Wang Qiuyu , Sun Hong , Fang Qiaoli , Xu Xiaozheng , Li Enmin , Li Chunquan 
Published: November 2022

Abstract
Chromatin regulators (CRs) regulate epigenetic patterns on a partial or global scale, playing a critical role in affecting multi-target gene expression. As chromatin immunoprecipitation sequencing (ChIP-seq) data associated with CRs are rapidly accumulating, a comprehensive resource of CRs needs to be built urgently for collecting, integrating, and processing these data, which can provide abundant annotated information on CR upstream and downstream regulatory analyses as well as CR-related analysis functions. This study established an integrative CR resource, named CRdb (http://cr.liclab.net/crdb/), with the aim of curating a large number of available resources for CRs and providing extensive annotations and analyses of CRs to help biological researchers clarify the regulation mechanism and function of CRs. The CRdb database comprised a total of 647 CRs and 2,591 ChIP-seq samples from more than 300 human tissues and cell types. These samples have been manually curated from NCBI GEO/SRA and ENCODE. Importantly, CRdb provided the abundant and detailed genetic annotations in CR-binding regions based on ChIP-seq. Furthermore, CRdb supported various functional annotations and upstream regulatory information on CRs. In particular, it embedded four types of CR regulatory analyses: CR gene set enrichment, CR-binding genomic region annotation, CR-TF co-occupancy analysis, and CR regulatory axis analysis. CRdb is a useful and powerful resource that can help in exploring the potential functions of CRs and their regulatory mechanism in diseases and biological processes.
The MHC Motif Atlas: a database of MHC binding specificities and ligands
Authors: Tadros Daniel M , Eggenschwiler Simon , Racle Julien , Gfeller David 
Published: November 2022

Abstract
The highly polymorphic Major Histocompatibility Complex (MHC) genes are responsible for the binding and cell surface presentation of pathogen or cancer specific T-cell epitopes. This process is fundamental for eliciting T-cell recognition of infected or malignant cells. Epitopes displayed on MHC molecules further provide therapeutic targets for personalized cancer vaccines or adoptive T-cell therapy. To help visualizing, analyzing and comparing the different binding specificities of MHC molecules, we developed the MHC Motif Atlas (http://mhcmotifatlas.org/). This database contains information about thousands of class I and class II MHC molecules, including binding motifs, peptide length distributions, motifs of phosphorylated ligands, multiple specificities or links to X-ray crystallography structures. The database further enables users to download curated datasets of MHC ligands. By combining intuitive visualization of the main binding properties of MHC molecules together with access to more than a million ligands, the MHC Motif Atlas provides a central resource to analyze and interpret the binding specificities of MHC molecules.
Introduction
Authors: Lewis Brown Robyn , Maroto Michelle , Pettinicchio David 
Published: November 2022

Abstract
The Oxford Handbook of the Sociology of Disability provides a timely and comprehensive overview of the wide range and depth of sociological theory and research on disability—brought together for the first time in one volume. Each section of the Handbook incorporates a uniquely sociological perspective, presented by experts on intersecting social, economic, political, and cultural dimensions of disability and complementing disability scholarship. The 37 chapters in this Handbook, organized into three major sections, provide an assessment of where we have been, where we are now, and where we must go with research on and in the sociology of disability. The first section, Defining, Measuring, and Understanding Disability, reviews frameworks foundational to the study of disability, pushes for the inclusion of broader global perspectives, and addresses important dimensions of representation. The second section, Experiencing Disability across the Life Course, presents a combination of perspectives that tie together individual biography, societal, and historical contexts, while emphasizing continuity and change in the dynamic processes linking individuals, institutions, and structures over time. In the third section, Disability, Policy, and the Law, chapters investigate the reproduction of inequality through law, policy, and related institutions and systems, while highlighting how social and political participation empowers people with disabilities and helps to mitigate inequalities and social marginalization. The chapters included in this volume offer a multifaceted resource for students and experienced scientists alike on historical developments, main standards, key issues, and current challenges in the sociological study of disability at the global, national, and regional levels.
Influence of Initial Health Care Provider on Subsequent Health Care Utilization for Patients With a New Onset of Low Back Pain: A Scoping Review
Authors: Zouch James , Comachio Josielli , Bussières André , Ashton-James Claire E , dos Reis Ana Helena Salles , Chen Yanyu , Ferreira Manuela , Ferreira Paulo 
Published: November 2022

Abstract

Objective
The aim of this research was to examine the scope of evidence for the influence of a nonmedical initial provider on health care utilization and outcomes in people with low back pain (LBP).

Methods
Using scoping review methodology, we conducted an electronic search of 4 databases from inception to June 2021. Studies investigating the management of patients with a new onset of LBP by a nonmedical initial health care provider were identified. Pairs of reviewers screened titles, abstracts, and eligible full-text studies. We extracted health care utilization and patient outcomes and assessed the methodological quality of the included studies using the Joanna Briggs Institute checklist. Two reviewers descriptively analyzed the data and categorized findings by outcome measure.

Results
A total of 26,462 citations were screened, and 11 studies were eligible. Studies were primarily retrospective cohort designs using claims-based data. Four studies had a low risk of bias. Five health care outcomes were identified: medication, imaging, care seeking, cost of care, and health care procedures. Patient outcomes included patient satisfaction and functional recovery. Compared with patients initiating care with medical providers, those initiating care with a nonmedical provider showed associations with reduced opioid prescribing and imaging ordering rates but increased rates of care seeking. Results for cost of care, health care procedures, and patient outcomes were inconsistent.

Conclusions
Prioritizing nonmedical providers at the first point of care may decrease the use of low-value care, such as opioid prescribing and imaging referral, but may lead to an increased number of health care visits in the care of people with LBP. High-quality randomized controlled trials are needed to confirm our findings.

Impact
This scoping review provides preliminary evidence that nonmedical practitioners, as initial providers, may help reduce opioid prescription and selective imaging in people with LBP. The trend observed in this scoping review has important implications for pathways of care and the role of nonmedical providers, such as physical therapists, within primary health care systems.

Lay Summary
This scoping review provides preliminary evidence that nonmedical practitioners, as initial providers, might help reduce opioid prescription and selective imaging in people with LBP. High-quality randomized controlled trials are needed to confirm these findings.
Can Clinical Postpartum Muscle Assessment Help Predict the Severity of Postpartum Pelvic Girdle Pain? A Prospective Cohort Study
Authors: Vesting Sabine , Gutke Annelie , Fagevik Olsén Monika , Praetorius Björk Marcus , Rembeck Gun , Larsson Maria E H 
Published: November 2022

Abstract

Objective
The purpose of this study was to evaluate whether the clinical assessment of pelvic floor muscles and the diastasis recti abdominis could predict the severity of pelvic girdle pain during the first year postpartum.

Methods
Between 2018 and 2020, 504 women were recruited to this prospective longitudinal cohort study. At 2 to 3 months postpartum, their pelvic floor muscles and diastasis recti abdominis were assessed using vaginal palpation, observation, and caliper measurement. The participants completed the Pelvic Girdle Questionnaire (PGQ) at 2 to 3, 6, 9, and 12 months postpartum. Mixed-effect models were used to determine how the results of pelvic floor muscle and diastasis recti abdominis assessments predicted the PGQ score. A sub-analysis for middle to high PGQ scores was conducted.

Results
Maximal voluntary pelvic floor muscle contractions ≥3 (Modified Oxford Scale, scored from 0 to 5) predicted a decreased PGQ score (β = −3.13 [95% CI = −5.77 to −0.48]) at 2 to 3 months postpartum, with a higher prediction of a middle to high PGQ score (β = −6.39). Diastasis recti abdominis width did not have any significant correlation with the PGQ score. A sub-analysis showed that a diastasis recti abdominis width ≥35 mm predicted an increased PGQ score (β = 5.38 [95% CI = 1.21 to 9.55]) in women with pelvic girdle pain.

Conclusion
The distinction between weak and strong maximal voluntary pelvic floor muscle contractions is an important clinical assessment in women with postpartum pelvic girdle pain. The exact diastasis recti abdominis width, measured in millimeters, showed no clinical relevance. However, a diastasis recti abdominis width ≥35 mm was associated with a higher PGQ score, and further research about this cutoff point in relation to pain is needed.

Impact
This study highlights the importance of clinical assessment of pelvic floor muscles in patients with postpartum pelvic girdle pain. A better understanding of the role of this muscle group will enable more effective physical therapist treatment of pelvic girdle pain.
Thumbs up or thumbs down: neural processing of social feedback and links to social motivation in adolescent girls
Authors: Davis Megan M , Modi Haina H , Skymba Haley V , Finnegan Megan K , Haigler Katherine , Telzer Eva H , Rudolph Karen D 
Published: November 2022

AbstractAdolescence is a period of rapid biological and psychological development, characterized by increasing emotional reactivity and risk-taking, especially in peer contexts. Theories of adolescent neural development suggest that the balance in sensitivity across neural threat, reward and regulatory systems contributes to these changes. Building on previous research, this study used a novel social feedback task to explore activation and functional connectivity in the context of social threat and reward in a sample of mid-adolescent girls (n = 86, Mage = 16.32). When receiving negative peer feedback, adolescents showed elevated activation in, and amygdala connectivity with, social processing regions [e.g. medial prefrontal cortex (mPFC) and temporoparietal junction (TPJ)]. When receiving positive feedback, adolescents showed elevated activation in social and reward (e.g. mPFC and ventromedial prefrontal cortex) processing regions and less striatum-cerebellum connectivity. To understand the psychological implications of neural activation and co-activation, we examined associations between neural processing of threat and reward and self-reported social goals. Avoidance goals predicted elevated amygdala and striatum connectivity with social processing regions [e.g. medial temporal gyrus (MTG)], whereas approach goals predicted deactivation in social processing regions (e.g. MTG/TPJ and precuneus), highlighting the importance of considering individual differences in sensitivity to social threat and reward in adolescence.
Historical Redlining and Contemporary Racial Disparities in Neighborhood Life Expectancy
Authors: Graetz Nick , Esposito Michael 
Published: November 2022

Abstract
While evidence suggests a durable relationship between redlining and population health, we currently lack an empirical account of how this historical act of racialized violence produced contemporary inequities. In this paper, we use a mediation framework to evaluate how redlining grades influenced later life expectancy and the degree to which contemporary racial disparities in life expectancy between Black working-class neighborhoods and White professional-class neighborhoods can be explained by past Home Owners’ Loan Corporation (HOLC) mapping. Life expectancy gaps between differently graded tracts are driven by economic isolation and disparate property valuation which developed within these areas in subsequent decades. Still, only a small percent of a total disparity between contemporary Black and White neighborhoods is explained by HOLC grades. We discuss the role of HOLC maps in analyses of structural racism and health, positioning them as only one feature of a larger public–private project conflating race with financial risk. Policy implications include not only targeting resources to formerly redlined neighborhoods but also the larger project of dismantling racist theories of value that are deeply embedded in the political economy of place.
Engineering of Co-Surfactant-Free Bioactive Protein Nanosheets for the Stabilisation of Bioemulsions Enabling Adherent Cell Expansion
Authors: Chrysanthou Alexandra , Bosch-Fortea Minerva , Gautrot Julien E. 
Published: November 2022

AbstractBioemulsions are attractive platforms for the scalable expansion of adherent cells and stem cells. In these systems, cell adhesion is enabled by the assembly of protein nanosheets that display high interfacial shear moduli and elasticity. However, to date, most successful systems reported to support cell adhesion to liquid substrates have been based on co-assemblies of protein and reactive co-surfactants, which limit the translation of bioemulsions. In this report, we describe the design of protein nanosheets based on two globular proteins, bovine serum albumin (BSA) and β-lactoglobulin (BLG), biofunctionalised with RGDSP peptides to enable cell adhesion. The interfacial mechanics of BSA and BLG assemblies at fluorinated liquid-water interfaces is studied by interfacial shear rheology, with and without co-surfactant acyl chloride. Conformational changes associated with globular protein assembly are studied by circular dichroism and protein densities at fluorinated interfaces are evaluated via surface plasmon resonance. Biofunctionalisation mediated by sulfo-succinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxylate (sulfo-SMCC) is studied by fluorescence microscopy. On the basis of the relatively high elasticities observed in the case of BLG nanosheets, even in the absence of co-surfactant, the adhesion and proliferation of mesenchymal stem cells and human embryonic kidney (HEK) cells on bioemulsions stabilized by RGD-functionalized protein nanosheets is studied. To account for the high cell spreading and proliferation observed at these interfaces, despite initial moderate interfacial elasticities, the deposition of fibronectin fibers at the surface of corresponding microdroplets is characterized by immunostaining and confocal microscopy. These results demonstrate the feasibility of achieving high cell proliferation on bioemulsions with protein nanosheets assembled without co-surfactants and establish strategies for rational design of scaffolding proteins enabling the stabilization of interfaces with strong shear mechanics and elasticity, as well as bioactive and cell adhesive properties. Such protein nanosheets and bioemulsions are proposed to enable the development of new generations of bioreactors for the scale up of cell manufacturing.
The impact of product name on consumer responses to meat alternatives
Authors: Ye Tian , Mattila Anna S. , Dai Shanshan 
Published: November 2022

Purpose
With the recent surge of plant-based menu items, it is critical to understand how to effectively communicate such products to consumers. This study aims to examine the impact of various descriptive names on consumers’ responses to novel meat alternatives in China, one of the emerging yet unexplored markets.

Design/methodology/approach
Two studies were conducted using a single factor ([descriptive name: “Renzao Rou [artificial meat]” vs “Sushi Rou [vegetarian/vegan meat]” vs “Zhiwu Rou” [plant-based meat]) between-subjects experimental design.

Findings
Study 1 shows that “Sushi Rou” and “Zhiwu Rou,” triggering more positive name associations, led to higher future consumption intention than “Renzao Rou.” A qualitative analysis demonstrates the differences in the name associations. Study 2 replicates the naming effect and examines the role of specific product attributes. Perceived health, naturalness and novelty are the main drivers of favorable responses to “Zhiwu Rou” (vs “Renzao Rou”), whereas perceived health, taste and naturalness mediate the positive effect for “Sushi Rou” (vs “Renzao Rou”).

Practical implications
Food service operators interested in introducing meat alternatives in China should carefully choose the product name to attract specific segments. International chains should consider cultural norms when expanding to emerging markets.

Originality/value
To the best of the authors’ knowledge, this study is the first to reveal the product naming effect on meat alternative products from the perspective of marketing communications. It contributes to a deeper understanding of the underlying mechanism driving Chinese consumers’ responses.
A behavioral economics approach to hospitality and tourism research
Authors: Song Haiyan , Lin Gabrielle 
Published: November 2022

Purpose
This study aims to critically evaluate hospitality and tourism demand research and introduce a behavioral economics approach to solve the problems faced by researchers.

Design/methodology/approach
Current issues in hospitality and tourism demand analysis are identified through critical reflection, and a behavioral economics approach is adopted to develop a new conceptual framework.

Findings
Four issues in hospitality and tourism studies are identified from the microeconomic theory and econometric modeling perspectives. The study’s demand framework provides both a theoretical underpinning and quantitative models to resolve the identified issues. With a focus on consumers’ cost–benefit assessments in light of individual differences and environmental factors, the authors’ conceptual framework represents a new effort to quantify hospitality and tourism demand at the disaggregate level with interactive multiple demand curve estimations.

Research limitations/implications
The study’s analytical framework for hospitality and tourism demand analysis is unique, and it fills the research gap. However, this research is still in the conceptual stage, and the authors leave it to future studies to empirically test the framework.

Practical implications
The proposed demand framework at the disaggregate level will benefit both private and public sectors involved in hospitality and tourism businesses in terms of pricing, marketing and policymaking.

Originality/value
The authors offer a new conceptual model that bridges the gap between aggregate and disaggregate hospitality and tourism demand analyses. Specifically, the authors identify research directions for future hospitality and tourism demand research involving individual tourists/consumers at the disaggregate level.
The asymmetrical linkage between oil price and banking stability in the MENA region
Authors: Mohammad Ahmed Rufai , Aliyu Sirajo 
Published: November 2022

Purpose
This paper aims to empirically investigate the asymmetrical relationship between changes in oil price and the banking stability of the conventional and Islamic banks in the Middle East and North African (MENA) countries.

Design/methodology/approach
This paper measures banking stability with Z-score and probability of default using the Generalized Method of Moment. This paper selects a sample of conventional and Islamic banks operating within the MENA oil-producing states between 2008 and 2016.

Findings
The result of this paper reveals that the banking stability of the two types of banks responds to positive and negative shocks in oil prices. Thus, the stability of conventional banks is slightly better than that of Islamic banks in the region. Consequently, this paper also reveals that bank capitalization improves with the banking stability of the two banking systems in the region.

Practical implications
The findings of this paper will help the banks in the MENA oil-producing countries with strategies for improving banking stability during the oil price fluctuations and provide the policymakers with possible time for bank capital reform.

Originality/value
This paper explores the impact of the international oil price shocks on Islamic and conventional banks in one of the essential global oil-producing regions. As such, this paper extends the banking stability literature by accounting for the role of oil shock prices on banking distance and the probability of default. To the best of the authors’ knowledge, this is the first investigation of different transmission channels of oil price fluctuations in the region while considering the dual banking system in the hub of Islamic banks.