bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Profile, Laboratory Parameters, Management and Outcomes of Newborns with Multisystem Inflammatory Syndrome (MIS-N) due to Transplacental Transfer of SARS-CoV 2 Antibodies
Authors: Balleda Lokeswari , Pasupula Saikiran , Kolla Sravani , Thimmapuram Chandrasekhara Reddy 
Published: April 2022

Background:
Multisystem inflammatory syndrome in children (MIS-C) is a well-known entity that occurs 3–4 weeks after COVID-19. A similar entity in newborns, known as Multisystem Inflammatory Syndrome in Newborns (MIS-N), is also described. However, the epidemiology, case definition, clinical presentations, and outcomes of MIS-N are still being updated. The presence of SARS CoV 2 antibodies in both the mother and the neonate suggests transplacental transfer of IgG antibodies causing cytokine storm and multisystem inflammatory syndrome in newborns (MIS-N).

Aims and Objectives:
To investigate the clinical characteristics, laboratory parameters, outcomes, and treatment modalities of neonates with multisystem inflammatory syndrome due to transplacental transfer of SARS CoV 2 antibodies. Materials and Methods: The study included eighteen consecutive neonates who met the MIS-C criteria. Following prior ethical clearance and consent from parents or guardians, socio-demographic data, lab parameters, clinical parameters, and treatment given were documented, tabulated, and analysed. Results: All of the 18 neonates had fever. The most common system involved was the respiratory system (15/18), followed by the cardiovascular system with coronary artery dilatations (10/18) and persistent pulmonary hypertension (4/18). All 17 cases (17/18) responded favourably to intravenous immunoglobulins (2 gm/kg) and intravenous dexamethasone (0.15 mg/kg). D-Dimers decreased significantly after treatment, with a p value of 0.01. One case with more than three systems involved (respiratory, CVS, CNS, and renal involvement) (1/18) resulted in death.

Conclusion:
A high index of suspicion is warranted in critically ill neonates, especially with fever, multisystem involvement and positive SARS CoV 2 antibodies. Fever may be a soft pointer to the diagnosis as fever is rare in neonates with other illnesses. Followup antibody titres are needed to document if there is any relationship between level of antibodies and disease. Safety of vaccination also needs to be addressed as antibodies are implicated in the etiopathogenesis of MIS-N.
Axitinib in Management of Renal Cell Carcinoma
Authors: Bhagat Sagar Bhimrao , Jadhav Amit Y , Patil Saiprasad V. , Barkate Hanmant Venkatrao 
Published: April 2022

Background:
Renal cell carcinoma (RCC) is the most common type of kidney cancer. Despite the availability of several tyrosine kinase inhibitors (TKI) and immunotherapies in India, the placing and sequencing of molecules in the management of RCC remains a source of dispute. The purpose of this qualitative survey was to get insight on the positioning of TKIs, specifically Axitinib, in the treatment of RCC.

Methodology:
This was a cross-sectional, questionnaire-based survey conducted across India among Medical Oncologist involved in the management of metastatic RCC. The questionnaire consists of 15 questions that were validated by a senior oncologist. The responses to the question were compiled in Microsoft Excel version 2018 and analyzed.

Results:
Total 51 oncologists completed this questionnaire. Majority preferred the International Metastatic RCC Database consortium risk stratification criteria. In favourable risk category sunitinib was preferred while in intermediate/poor risk patient's axitinib plus pembrolizumab was preferred by majority. Pazopanib and axitinib was favoured in patients with advanced age and comorbidities. Axitinib was the choice in patients who had good response to 1st line therapy and who have visceral metastasis. Majority of oncologists endorsed the use of axitinib in elderly with comorbid patients because of its favourable efficacy and tolerability.

Conclusion:
Axitinib is preferred choice in metastatic RCC patients who have responded well to TKIs in the first line, in elderly patients with associated comorbidities, in patients with renal impairment and in patients with poor performance status. It is a well-tolerated drug with minimal adverse effects which are transient in nature.
Implementation of teaching strategies and innovation to comply with the training competencies in an ophthalmology residency program during the coronavirus disease-19 pandemic
Authors: Gonzalez-Garcia Angel Eduardo , Macias-Rodriguez Yolanda , Ruiz-Lozano Raul E. , Rodriguez-Garcia Alejandro 
Published: April 2022

Purpose:
The coronavirus disease (COVID)-19 pandemic put medical residency programs in a predicament, impacting clinical attention and surgical practice. This study aims to describe the adjustments applied in an ophthalmology residency program to overcome the COVID-19 pandemic restrictions.

Materials and Methods:
An observational, comparative, and descriptive study was performed in an ophthalmology residency program to analyze the adaptations and innovations implemented to overcome the medical attention and training restrictions enforced by the sanitary authorities due to the COVID-19 pandemic in the year 2020. The residents' record folders were analyzed yearly for academic, research, clinical, and surgical activities from 2018 to 2020. An online survey was applied to residents for congress attendance, research publications, time spent on classes, lectures, clinical cases, journal club, and surgical videos sessions during the pandemic.

Results:
Compared to years 2018 and 2019, during 2020, there was a significant increase in the hours destined per week to academic activities (6.04 vs. 16.42 h, P < 0.001); the monthly hours of journal club sessions (0.5 vs. 3.41 h, P < 0.001); and the number of published articles involving residents (0.4 vs. 2.52, P < 0.001). On the contrary, the hours of outpatient consultation (8 h/day vs. 4 h/day) and the number of cataract surgeries performed per resident decreased (48 vs. 15, P < 0.001) from 2019 to 2020.

Conclusions:
Prompt reaction and innovation were required to overcome the educational and training barriers imposed by the COVID-19 pandemic. While remote academic activities increased significantly, online patient consultation and surgical simulation were necessary to avoid hindering patient's attention and surgical training.
Relationship of Quantitative Traits in Different Morphological Characters of Pea (Pisum Sativum L.)
Authors: Tasnim Sarah , Poly Nilufa Yasmin , Jahan Nusrat , Khan Ahasan Ullah 
Published: April 2022

An experiment was undertaken to elucidate the genetic relationship between different quantitative traits for commercial cultivation and to evaluate selection criteria in pea breeding programs in five inbred parents. Their 17 F4’s derivatives in pea (Pisum sativum L.) evaluated ten characters during the winter season (November to February) of 2017-18 at the research farm, BSMRAU, Gazipur, Bangladesh. Analysis of variance explored significant differences among the genotypes for all the characters. Phenotypic coefficients of variation (PCV) were close to genotypic coefficients of variation (GCV) for all the characters indicating less influence on the environment and potentiality of selection. A high heritability relationship with high genetic advance was observed for plant height, pod per plant, hundred seed weight, and seed yield per plot. Pod length showed a highly significant positive correlation with pod width and hundred seeds weight. Only days to first flowering showed a highly negative correlation with pod length and hundred seed weight. Path coefficient analysis revealed that plant height, pod per plant, and seeds per pod had a highly positive effect on yield per plant. Therefore, associating and selecting those traits, yield improvement must be possible in pea, and the days to maturity, plant height, pods per plant, pod length, and seed showed a considerable positive and highly significant correlation with plant height, pod per plant, seed per pod, and yield per plant at both genotypic and phenotypic levels indicating yield could be increased with the increase of days to maturity, plant height, pods per plant, pod length, and seed.
Early-Middle Jurassic lithological and depositional facies of the Da Lat back-arc basin
Authors: Bui Huy Hoang , Nguyen Quang Tuan 
Published: April 2022

The Da Lat back-arc basin formed on a deformed lithosphere caused by subduction of the Paleo-Pacific plate under Eurasia in the Mesozoic.
Lithology and sedimentary structure analysis from field works and UAV imaging show that the Early-Middle Jurassic deposits in this area can be divided into 7 types of litho-depositional facies: (i) coastal conglomerate; (ii) channel/shallow lake sandstone; (iii) shoreface sandstone; (iv) estuarine siltstone and mudstone; (v) deep marine shale; (vi) mass transport deposits; and (vii) turbidite.
These facies’ spatio-temporal distributions are closely related to their grain size. In the basin margin, Early Jurassic coarse-grained deposits are exposed, marking the opening of the basin, grading upward into shallow marine-shelf deposits. In the Middle Jurassic, the basin margin was uplifted corresponding to continental depositional environment, while the basin centre was filled by outer shelf deposits, reflecting a deepening process. Interbedding with these deposits are near shore and estuarine deposits.
Digital transformation characteristics and trends in petroleum exploration and production
Authors: Nguyen Anh Duc 
Published: April 2022

Digital transformation is an urgent solution for the oil and gas industry in the energy transition trend, helping oil and gas enterprises optimise oil and gas exploration, development and production costs, and improving the competitiveness of oil and gas in comparison with other energy sources, especially new and renewable energy sources.
The article provides an overview of the digital transformation trends in petroleum exploration and production, the current status of digital technology application, difficulties and barriers, thereby making some recommendations on the objectives and orientations for the implementation of digital transformation in petroleum exploration and production in Vietnam.
An assessment of the potential of offshore wind power services market and opportunities for oil and gas service companies to 2030
Authors: Nguyen Thu Ha , Vu Tuyet Vy , To Minh Hieu 
Published: April 2022

In the context of energy transition, major oil and gas companies (such as Total, BP, Equinor, Shell, Eni, Petronas, and Osted, etc.) have diversified their investment portfolios with new energy projects, including those in offshore wind power.
Resolution No. 55-NQ/TW dated 11 February 2020 of the Politburo on the orientation of Vietnam's national energy development strategy to 2030, vision to 2045 sets the target: the proportion of renewables in the total primary energy supply will reach about 15-20% by 2030; and 25 - 30% by 2045. For wind power, priority should be given to development in accordance with the ability to ensure system safety with reasonable electricity prices; and formulation of supporting policies and breakthrough mechanisms for offshore wind power development in association with the implementation of the Vietnam Maritime Strategy.
The paper focuses on assessing the potential market size for wind power services to 2030 and evaluating the possibility of diversification to include the offshore wind power supply chain of Petrovietnam’s service companies.
Genome-wide analysis of lncRNAs, miRNAs and mRNAs forming a prognostic scoring model associated with the recurrence of osteosarcoma
Authors: zhang minglei , liu yang , Kong Daliang 
Published: April 2022

IntroductionPurpose: Among young adults and adolescents, the most common malignant bone tumor is osteosarcoma (OS). Even patients who are cured by surgery or neoadjuvant chemotherapy still have a high possibility of recurrence. In recent years, due to the development of molecular biology research methods, many new prognostic markers based on the gene level have emerged. In addition, the mutual regulation mode among long non-coding RNA (lncRNA), miRNA and target genes are closely related to the occurrence and development of tumors. In our research, we aimed to analyze the molecular regulation mode and predict clinical outcomes by integrate three types of RNA expression.Material and methodsMaterials and Methods: We obtained the data of OS patients from The Cancer Genome Atlas (TCGA) database including expression data (RNA and miRNA expression data) and clinical data.ResultsResults: After differential gene expression analysis, Cox regression analysis and functional enrichment analysis, 1 lncRNA, 3 miRNAs and 9 mRNAs were identified as prognostic RNA. We constructed the prognostic scoring (PS) model with high predicting prognosis performance. Using PS models and clinical data, we established a nomogram to calculate patients' 3-year and 5-year survival rates.ConclusionsConclusions: Finally, competing endogenous RNAs (ceRNAs) network and functional enrichment analysis help us to understand molecular mechanisms associated with the recurrence of osteosarcoma.
Efficacy and safety of Apixaban and warfarin in the prevention of ischemic stroke：A systematic review and a meta-analysis
Authors: Gu Wei , Luo Jianghong , Zhang Fang , Hong Jiankun , Chen Jianping , huang ying , Xie Wei 
Published: April 2022

IntroductionDue to various limitations of warfarin use, non-vitamin K oral anticoagulants have gradually become the first choice for the prevention of ischemic stroke. This article will comprehensively and systematically evaluate the efficacy and safety of apixaban and warfarin in the prevention of ischemic stroke, to provide evidence-based reference for clinical diagnosis and treatment.Material and methodsA comprehensive search of electronic databases, including PubMed, Embase, Cochrane Library, Web of Science, Clinical Trials, China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), and Wanfang Database, was performed, and the cut-off date for all databases was May 31, 2021. We reviewed a large number of literatures on apixaban versus warfarin in the prevention of ischemic stroke. We compared the incidence of ischemic stroke, any other thromboembolic events, major bleeding, intracranial hemorrhage, and gastrointestinal hemorrhage.ResultsFrom the initial search of 288 results, the final meta-analysis consisted of 11 studies, including 6 retrospective cohort studies, 4 observational studies, and 1 randomized controlled trial, with a total of 240652 patients. There was no statistically significant difference between apixaban and warfarin in incidence of ischemic stroke [OR=0.80, 95%CI (0.56, 1.16), P=0.25] and thromboembolic event [OR=0.83, 95%CI (0.63, 1.10), P=0.19]. In apixaban group, major bleeding [OR=0.68, 95%CI (0.55, 0.84), P=0.0003], intracranial hemorrhage [OR=0.48, 95%CI (0.42, 0.56), P<0.00001], gastrointestinal hemorrhage (OR=0.66, 95%CI (0.60, 0.72), P < 0.00001) was significantly lower than in warfarin group.ConclusionsApixaban has more advantages and a higher safety profile than warfarin, making it worthy of widespread use.
ACOLHIMENTO MULTIPROFISSIONAL EM UNIDADE DE CUIDADOS INTERMEDIÁRIOS
Authors: Gonçalves da Silva Marcelo , Tamisari Pereira Ana Carla , Roques Dauzacker Robson Adriani , Fonseca Wanaline , Bernal Jaqueline , Silva Santos Viviane , Maciel Garcia Eloy Aparecido , Lopes Luzi Sandra , Dan Bianchi de Souza Nádia , Costa de Almeida Cabral Maria Carolina 
Published: April 2022

Introdução: A ausência de compreensão frente à doença permaneceu estática durante muito tempo e o movimento médico para aliviar os pesares dos afetados, era nulo e a estes, restava o sofrimento, a exclusão social dada o medo de contágio, e a morte. Tais atitudes, tendem a desencorajar a formação de vínculos significativos que mediante os quais se nutrem as forças de invenção e de resistência que constroem nossa própria humanidade. Objetivo: trazer um processo reflexivo frente aos mecanismos de organização de uma unidade de cuidados intermediários e dos reflexos da política nacional de humanização dentro dela. Material e Método: Realizou-se uma busca sistemática nos indexadores eletrônicos Scielo, Biblioteca Virtual em Saúde e Repositório da Fiocruz. Os termos foram buscados utilizando os seguintes limites: pesquisa com seres humanos; línguas: português, inglês e espanhol; contendo as palavras-chave no título/resumo. A partir disso, pode-se construir uma revisão bibliográfica, que tem como “vantagem principal permitir ao pesquisador a cobertura de fenômenos muito mais amplo do que aquela que poderia diretamente”. Resultados: O serviço oferecido por uma unidade de cuidados intermediários é direcionado a pacientes com necessidades de monitorização contínua e cuidados da equipe multidisciplinar especializada. Nesse sentido, a humanização ganha destaque como ferramenta de acolhida e atribuição de sentidos a condição de saúde e doença. Conclusão: A acolhida multiprofissional deve contemplar o todo do sujeito, uma vez que este reflete dimensões biopsicossociais, e a qualidade da assistência nesse sentido, os processos de humanização denotam a possibilidade de que o doente tenha compreensão de sua condição física e biológica, além da viabilização da ressignificação das condições da doença.
Die Bärenfalle
Authors: Vetter Bernhard 
Published: April 2022

Frankfurt a.M. Im Dezember 2021 hat die agrarzeitung berichtet, dass bei einer Tochtergesellschaft der HaGe Kiel ein Geschäft mit Rapskontrakten schief lief. Jetzt zeigt sich: Der Schaden ist fast so hoch wie damals vermutet.
Nisan Savaşlarından Vatan Muharebesine: Azerbaycan’da “Böyük Qayıdış” Süreci Üzerine Bir Değerlendirme
Authors: SİPAHİ Esra Banu , ÖZSOY Bahar , QASIMLI Musa 
Published: April 2022

1994 yılında Ermenistan ve Azerbaycan arasında bir ateşkes anlaşması imzalansa da sınır hattında zaman zaman şiddeti artan çatışmalar yaşanmaya devam etmiştir. Bu çatışmaların en kapsamlı olanı 2-5 Nisan 2016 tarihlerinde gerçekleşen Dört Gün Savaşları’dır. Dört Gün Savaşları, Azerbaycan-Ermenistan sorununun çözümüne yönelik ilginin azaldığı bir dönemde Karabağ meselesini uluslararası alanda yeniden gündeme getirerek savaş seçeneğinin aslında ortadan kalkmadığına dikkat çekmiştir. Nitekim 27 Eylül-10 Kasım 2020 tarihleri arasında yaşanan savaşta Azerbaycan’ın topraklarının büyük bir kısmını Ermeni işgalinden kurtarmayı başarması ile bölge sakinlerinin geri dönüşü için çalışmalar başlatılmıştır.
Dört Gün Savaşları sonrasında Azerbaycan kamuoyunda “Böyük Qayıdış” olarak nitelendirilen Çocuq Mərcanlı köyünün yerleşime açılması, İkinci Karabağ Savaşı’nda işgalden kurtarılan kentlerin yeniden yapılandırılması için bir pilot proje görevi görmüştür. Bu çalışmada, Çocuq Mərcanlı köyünün sözü edilen simgesel anlamından hareketle, savaş sonrası süreçte işgalden kurtarılan toprakların yerleşime açılması için yürütülen faaliyetler ve geri dönüş politikasının, bir yeniden doğuş öyküsüne dönüştürülebilirliği analiz edilmektedir.
Inclisiran (Leqvio)
Authors: Reimbursement Team  
Published: April 2022

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses inclisiran (Leqvio), 284 mg in 1.5 mL (189 mg/mL) solution for SC injection.
Indication: As an adjunct to lifestyle changes, including diet, to further reduce low-density lipoprotein cholesterol (LDL-C) level in adults with the following conditions who are on a maximally tolerated dose of a statin, with or without other LDL-C-lowering therapies:

heterozygous familial hypercholesterolemia (HeFH), or
non-familial hypercholesterolemia with atherosclerotic cardiovascular disease.
Ground-based Ku-band microwave observations of ozone in the polar middle atmosphere
Authors: Newnham David A. , Clilverd Mark A. , Clark William D. J. , Kosch Michael , Verronen Pekka T. , Rogers Alan E. E. 
Published: April 2022

Abstract. Ground-based observations of 11.072 GHz atmospheric ozone (O3) emission have been made using the Ny-Ålesund Ozone in the
Mesosphere Instrument (NAOMI) at the UK Arctic Research Station (latitude 78∘55′0′′ N, longitude
11∘55′59′′ E), Spitsbergen. Seasonally averaged O3 vertical profiles in the Arctic polar
mesosphere–lower thermosphere region for night-time and twilight conditions in the period 15 August 2017 to 15 March 2020 have been retrieved over
the altitude range 62–98 km. NAOMI measurements are compared with corresponding, overlapping observations by the Sounding of the Atmosphere
using Broadband Emission Radiometry (SABER) satellite instrument. The NAOMI and SABER version 2.0 data are binned according to the SABER instrument
60 d yaw cycles into nominal 3-month “winter” (15 December–15 March), “autumn” (15 August–15 November), and “summer”
(15 April–15 July) periods. The NAOMI observations show the same year-to-year and seasonal variabilities as the SABER 9.6 µm
O3 data. The winter night-time (solar zenith angle, SZA ≥ 110∘) and twilight (75∘ ≤ SZA ≤ 110∘)
NAOMI and SABER 9.6 µm O3 volume mixing ratio (VMR) profiles agree to within the measurement uncertainties. However, for
autumn twilight conditions the SABER 9.6 µm O3 secondary maximum VMR values are higher than NAOMI over altitudes
88–97 km by 47 % and 59 %, respectively in 2017 and 2018. Comparing the two SABER channels which measure O3 at different
wavelengths and use different processing schemes, the 9.6 µm O3 autumn twilight VMR data for the three years 2017–2019 are
higher than the corresponding 1.27 µm measurements with the largest difference (58 %) in the 65–95 km altitude range
similar to the NAOMI observation. The SABER 9.6 µm O3 summer daytime (SZA < 75∘) mesospheric O3 VMR is
also consistently higher than the 1.27 µm measurement, confirming previously reported differences between the SABER 9.6 µm
channel and measurements of mesospheric O3 by other satellite instruments.