bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of Cluster Headache by Occipital Nerve Stimulation: Case Report
Authors: Oliveira Andressa Lima , Monteiro Vitória Harumi Rodrigues Takahashi , Silva Ledismar José da 
Published: August 2022

AbstractCluster headache (CH) is a primary headache characterized by severe pain that is strictly unilateral, with orbital, supraorbital, or temporal location, accompanied by ipsilateral autonomic manifestations. It has a considerable socioeconomic impact and impairs patients' quality of life. The present study aimed to report the case of a patient presenting with CH who underwent occipital nerve stimulation and to verify the improvement in her quality of life after this procedure.
Primary Cervical Carcinosarcoma: Report of a Rare Case
Authors: Tsatsaris Georgios , Fasoulakis Zacharias , Koutras Antonios , Ntounis Thomas , Samara Athina A. , Syllaios Athanasios , Diamantis Alexandros , Kouroupi Maria , Stamos Charilaos , Kontomanolis Emmanuel N. 
Published: August 2022

AbstractBackground Carcinosarcomas are malignant mixed Müllerian tumors (MMMT), containing both epithelial and mesenchymal components. Carcinosarcomas of the uterine cervix comprise an extremely rare histopathological entity, with less than 150 cases reported in the literature to date.Materials and Methods A 79-year-old postmenopausal female patient was referred to our gynecological department due to a pelvic mass and vaginal bleeding. A cervical curettage was performed and the histological report revealed a malignant neoplasm with high cellularity consisting of two components; the first was a chondrosarcoma and the latter a adenocarcinoma. A diagnosis of MMMT was confirmed through immunohistochemical (IHC) staining. Neoadjuvant chemotherapy and radiotherapy were implemented, and a year later the patient underwent a radical hysterectomy and oncological pelvic lymph node dissection. She remains disease-free 12 months postoperatively.Conclusion Primary cervical carcinosarcomas are extremely rare tumors demonstrating a bipartite profile. Preoperative diagnosis with appropriate immunochemistry testing of this rare entity is crucial to decision making.
Tratamento de lesões agudas da medula espinal: Uma pesquisa entre cirurgiões de coluna ibero-americanos – Parte 2: Momento da cirurgia
Authors: Ribau Ana , Alves Jorge , Rodrigues-Pinto Ricardo 
Published: August 2022

Resumo
Objetivo O objetivo do presente estudo foi avaliar a prática atual em termos de momento de realização da cirurgia em pacientes com lesão medular aguda (LMA) entre cirurgiões de coluna de países ibero-americanos.
Métodos Estudo transversal descritivo com base em um questionário enviado por correio eletrônico para todos os membros da Sociedad Ibero Latinoamericana de Columna (SILACO, na sigla em espanhol) e sociedades associadas.
Resultados Um total de 162 cirurgiões responderam a perguntas relacionadas ao momento da cirurgia. Sessenta e oito (42,0%) consideraram que a LMA com lesão neurológica completa deve ser tratada em até 12 horas, 54 (33,3%) realizariam a descompressão precoce em até 24 horas e 40 (24,7%) fariam este procedimento nas primeiras 48 horas. Em relação à LMA com lesão neurológica incompleta, 115 (71,0%) operariam nas primeiras 12 horas. Houve diferença significativa na proporção de cirurgiões que fariam o tratamento cirúrgico da LMA em ≤ 24 horas quanto ao tipo de lesão (lesão completa [122] versus lesão incompleta [155]; p<0.01). Em pacientes com síndrome medular central sem evidência radiológica de instabilidade, 152 cirurgiões (93,8%) realizariam a descompressão cirúrgica: 1 (0,6%) nas primeiras 12 horas, 63 (38,9%) em 24 horas, 4 (2,5%) em 48 horas, 66 (40,7%) no internamento inicial e 18 (11,1%) após a estabilização neurológica.
Conclusão Todos os cirurgiões participantes favoreceram a descompressão precoce; a grande maioria realizaria a cirurgia nas primeiras 24 horas. A descompressão é feita antes em casos de lesões incompletas do que em lesões completas. Nos casos de síndrome medular central sem evidência radiológica de instabilidade, há uma tendência à descompressão cirúrgica precoce, mas o momento de intervenção ainda é extremamente variável. Estudos futuros são necessários para identificar o momento ideal para descompressão neste subconjunto de pacientes com LMA.
Insulectomy for Refractory Epilepsy: Case Series and Literature Review
Authors: Rodrigues Adriano de Medeiros Barbosa , Bernardo Henrique Nicola Santo Antonio , Seba Maria Clara Cardoso , Junior Carlos Alberto de Almeida Castro , Franceschini Paulo Roberto , Aguiar Paulo Henrique Pires de 
Published: August 2022

AbstractSurgical resection of the insula (insulectomy) is a procedure used for brain lesions and for refractory epilepsy. It has a difficult surgical access and the need of a wide anatomical knowledge and preoperative planning. There are two types of surgical approaches aiming the exposure of the insular cortex: transsylvian and transcortical. The importance of insulectomies is the efficacy in providing a remarkable decrease in seizures. The objective of the present article is to document the results of a series of 10 patients submitted to insulectomies for refractory epilepsies and compare them with the results of other studies reported in the literature, as well as to describe the main nuances of the surgical approaches and their associated risks. In the new case series, all patients corresponded to preoperative Engel classification IV for; after a mean 2-year follow-up period, they corresponded to Engel classification II. A subtotal resection was performed in six patients, and the remaining four underwent a partial resection, most of them leading to temporary complications. The literature review endorsed the good outcomes of the casuistry. A critical analysis of the presented data reiterates the opinion of several authors that insulectomies are beneficial and safe for the patients. A broad anatomical knowledge of the insular region, preoperative planning (limits of resections), and the use of modern microsurgical techniques must be considered as basic principles by neurosurgeons for the prevention of perioperative morbidities. Insulectomies are safe and effective, although they result in temporary postoperative complications, and provide highly satisfactory results in terms of seizure control.
Tratamento das lesões agudas da medula espinal: Uma pesquisa entre cirurgiões de coluna iberoamericanos – Parte 1: Uso de corticosteroides em altas doses
Authors: Ribau Ana , Alves Jorge , Rodrigues-Pinto Ricardo 
Published: August 2022

Resumo
Objetivo O objetivo do presente estudo foi avaliar a prática atual de uso do succinato sódico de metilprednisolona (MPSS, na sigla em inglês) nas lesões agudas da medula espinal (LAMEs) entre cirurgiões de coluna de países ibero-americanos.
Métodos Um estudo transversal descritivo foi realizado. O questionário continha duas seções, uma sobre os dados demográficos dos cirurgiões e acerca da administração de MPSS, e foi enviado por correio eletrônico aos membros da Sociedad Ibero Latinoamericana de Columna (SILACO, na sigla em espanhol) e sociedades associadas.
Resultados No total, 182 cirurgiões participaram do estudo: 65,4% (119) eram cirurgiões ortopédicos e 24,6% (63), neurocirurgiões. Sessenta e nove (37,9%) usaram MPSS no tratamento inicial da LAME. Não houve diferenças significativas entre países (p = 0,451), especialidades (p = 0,352) ou senioridade do cirurgião (p = 0,652) em relação ao uso de corticosteroides no tratamento inicial da LAME. Destes, 45 (65,2%) relataram a administração de um bolus de alta dose (30 mg/kg) seguido por perfusão (5,4 mg/kg/h). Quarenta e seis (66,7%) dos cirurgiões que usam MPSS apenas o prescrevem a pacientes tratados nas primeiras 8 horas após a LAME. A maioria dos cirurgiões (50,7% [35]) administrou corticosteroides em alta dose devido à convicção de seus benefícios clínicos e melhora da recuperação neurológica.
Conclusão Os resultados do presente questionário mostram que o uso de MPSS na LAME não está disseminado entre os cirurgiões de coluna e que a controvérsia sobre sua administração ainda não foi resolvida. É provável que isto se deva ao baixo nível de evidência dos dados existentes, a variações ao longo dos anos, a inconsistências nos protocolos terapêuticos agudo e a diferentes sistemas de saúde.
The Current Role of Arthroscopy in Traumatic Wrist Injuries: An Expert Survey
Authors: d'Ailly Philip N. , Mulders Marjolein A.M. , Coert J. Henk , Schep Niels W.L. ,   Members of IWAS
Published: August 2022

Abstract
Background Wrist arthroscopy has become increasingly popular for diagnosing and treating traumatic wrist injuries. How wrist arthroscopy has influenced the daily practice of wrist surgeons remains unclear. The objective of this study was to evaluate the role of wrist arthroscopy for the diagnosis and treatment of traumatic wrist injuries among members of the International Wrist Arthroscopy Society (IWAS).
Methods An online survey was conducted among IWAS members between August and November 2021 with questions regarding the diagnostic and therapeutic importance of wrist arthroscopy. Questions focused on traumatic injuries of the triangular fibrocartilage complex (TFCC) and scapholunate ligament (SLL). Multiple-choice questions were presented in the form of a Likert scale. The primary outcome was respondent agreement, defined as 80% answering similarly.
Results The survey was completed by 211 respondents (39% response rate). The majority (81%) were certified or fellowship-trained wrist surgeons. Most respondents (74%) had performed over 100 wrist arthroscopies. Agreement was reached on 4 of the 22 questions. It was agreed that the outcomes of wrist arthroscopy strongly depend on surgeons' experience, that there is sufficient evidence for the diagnostic purposes of wrist arthroscopy, and that wrist arthroscopy is better than magnetic resonance imaging (MRI) for diagnosing TFCC and SLL injuries. No agreement was reached on the preferred treatment of any type of TFCC or SLL injury.
Conclusion There is agreement that wrist arthroscopy is superior to MRI for diagnosing traumatic TFCC and SLL injuries, yet experts remain divided on the optimal management. Guidelines need to be developed for the standardization of indications and procedures.
Level of Evidence This is a Level III study.
Pacientes com capsulite adesiva relatam melhora da funcionalidade pela Classificação Internacional de Funcionalidade, Incapacidade e Saúde e DASH após bloqueios do nervo supraescapular
Authors: Nunes Sara Ribeiro , Andrade Fernanda Guimarães de , Fernandes Marcos Rassi 
Published: August 2022

Resumo
Objetivo Avaliar a funcionalidade em pacientes com capsulite adesiva submetidos a bloqueio do nervo supraescapular (BNSE).
Métodos Um estudo clínico prospectivo do tipo antes e depois foi realizado em um único centro com pacientes com capsulite adesiva secundária tratados com quatro bloqueios baseados em limites anatômicos. A amostra foi não probabilística, tendo sido obtida após consulta de rotina em ambulatório especializado. Os instrumentos utilizados para avaliação foram a Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF) e o questionário de Disfunções do Braço, Ombro e Mão (DASH), que foram aplicados antes da intervenção (T0), uma semana após o quarto BNSE (T4), e três após o primeiro BNSE #x0028;T12#x0029;. As médias dos itens da CIF e do DASH nos diferentes tempos (T0 x T4; T4 x T12; e T0 x T12) foram comparadas por meio do teste t pareado. A probabilidade de rejeitar a hipótese nula foi de 5%.
Resultados A amostra foi composta por 25 indivíduos com média de idade de 58,16 anos; 16 eram mulheres. A duração dos sintomas dolorosos variou de 2 a 16 meses, com média de 5,92 meses. A CIF mostrou que todos os domínios já haviam melhorado em T4, à exceção dos fatores ambientais, que só melhoraram aos 3 meses (p = 0,037). Os pacientes já relataram melhora na função do ombro em T4 e mais ainda em T12, ao final da coleta de dados (p = 0,019).
Conclusão A técnica de BNSE é eficaz em pacientes com capsulite adesiva após 4 semanas de aplicação, com melhora da funcionalidade do indivíduo e sua manutenção até 12 semanas.
Enantioselective Oxidative Dearomatization of 2-Naphthols ­Enabled by Chiral Organoiodine Catalysis
Authors: Gong Liu-Zhu , Zhang Dong-Yang 
Published: August 2022

AbstractAn asymmetric dearomatizative oxidation of 2-naphthol derivatives has been established by organoiodine catalysis, enabling a series of chiral spirooxindoles with various functional groups to be accessed in high yields and high enantioselectivities under mild conditions.
Obesity and Physical Activity in Ostomized Patients
Authors: Macedo Keila Marcia Ferreira , Souza Ana Luiza Lima , Almeida Fabio Marques , Costa Nayara Tamillis Gonçalves Cruz , Oliveira Wagna Maria Araújo , Barbosa Maria Alves , Oliveira Ênio Chaves 
Published: August 2022

Abstract
Introduction The relationship between obesity and physical activity is still unknown in specific groups, such as people living with ostomies.
Objective To assess the prevalence of obesity and the level of physical activity in ostomized individuals.
Methods A cross-sectional study with a population of ostomized patients in two hospitals of a Brazilian city. Obesity was assessed by the Body Mass Index (BMI) and physical activity, by the International Physical Activity Questionnaire.
Results The study included 148 patients (55.4% of men [82]), with a mean age of 58.5 (±17.8) years, with 56.1% (83) of the sample aged 60 or older. Colostomies were identified as definitive in 67.6% (100), there were 28 cases (18.9%) of obesity, 67 (45.3%) overweight patients, and 31 (20.9%) subjects were underweight. Sedentary lifestyle was identified in 40.5% (60) of the participants. The mean BMI was significantly higher in men (25.9 ± 5.1), and a higher proportion of men were overweight (28; 34.1%); the underweight group had a greater proportion of women (20; 30.3%). An association between physical inactivity and underweight (p = 0.003) was found.
Conclusion Most patients with ostomies, especially colostomies, are men over 60 years of age who are overweight or obese. In general, underweight individuals are more sedentary.
The Impact of COVID-19 Lockdown on Pediatric Hospital Admissions in Turkey
Authors: Erdede Ozlem , Sarı Erdal , Uygur Külcü Nihan , Sezer Yamanel Rabia Gönül 
Published: August 2022

Abstract
Objective Health care utilization has declined significantly during the coronavirus disease 2019 (COVID-19) pandemic. We aimed to analyze the impact of COVID-19 lockdowns on pediatric admissions in a Turkish medical center.
Methods This retrospective study was conducted by analyzing the numbers and records, including diagnoses, of patients admitted to our pediatric department between March 11, 2020 (the day of the first confirmed COVID-19 case in Turkey) and June 11, 2020 and comparing it with the diagnoses and numbers for the same period in 2019. The most common reasons for admissions were investigated.
Results Totally, 89,607 patients were included. Patient visits reduced drastically by 63.11 to 36.89% during the lockdown period compared to the preceding year. In addition to the impact of COVID-19 lockdowns on the total volume of patients, we observed significant variations in the distribution of diagnoses among children. The percentage of respiratory, gastrointestinal, immunological, and ophthalmologic diseases and allergic reactions statistically decreased (p < 0.001). In contrast, the relative percentage of neonatal, urogenital, neurological, cardiovascular, hematological, and dermatological diseases significantly increased (p < 0.001) among emergency department (ED) admissions. Notably, the percentage of respiratory diseases among ED patients decreased by 66.81 to 33.19%.
Conclusion COVID-19 strongly affected health care utilization. The public must be educated about the safety of hospital environments, and families should be encouraged to visit hospitals in case of emergencies. Additionally, changes in public health advice may help alter health care consumption patterns.
Pitfalls of quantifying intersystem crossing rates in singlet-fission chromophore solutions
Authors: Stuart Alexandra N. , Tapping Patrick C. , Kee Tak W. , Huang David M. 
Published: August 2022

Singlet fission (SF), a process that produces two triplet excitons from one singlet exciton, has attracted recent interest for its potential to circumvent the detailed-balance efficiency limit of single-junction solar cells. For the potential of SF to be fully realized, accurate assignment and quantification of SF is necessary. Intersystem crossing (ISC) is another process of singlet to triplet conversion that is important to distinguish from SF to avoid either over- or under-estimation of SF triplet production. Here, we quantify an upper bound on the rate of ISC in two commonly studied SF chromophores, TIPS–pentacene and TIPS–tetracene, by using transient absorption spectroscopy of solutions of varying concentrations in toluene. We show that SF in solutions of these acenes has previously been misidentified as ISC, and vice versa. By determining a bimolecular SF rate constant in concentrated solutions in which SF dominates over ISC, we distinguish triplet formation due to SF from triplet formation due to ISC and show that the characteristic time scale of ISC must be longer than 325 ns in TIPS–pentacene, while it must be longer than 118 ns in TIPS–tetracene. We additionally note that no excimer formation is observed in the relatively dilute (up to 8 mM) solutions studied here, indicating that previous excimer formation observed at much higher concentrations may be partially due to aggregate formation. This work highlights that an accurate quantification of ISC is crucial as it leads to accurate determination of SF rate constants and yields.
Role of bimetallic Au–Ir subnanometer clusters mediating O2 adsorption and dissociation on anatase TiO2 (101)
Authors: Fabila J. , Romero D. , Paz-Borbón O. , Buendía F. 
Published: August 2022

A comprehensive computational study on the oxygen molecule (O2) adsorption and activation on bimetallic Au–Ir subnanometer clusters supported on TiO2(101)— up to five atoms in size—is performed. A global optimization density functional theory-based basin-hopping algorithm is used to determine putative global minima configurations of both mono- and bimetallic clusters supported on the metal oxide surface for all sizes and compositions. Our results indicate a strong cluster-oxide interaction for monometallic Ir clusters with calculated adsorption energy (Eads) values ranging from −3.11 to −5.91 eV. Similar values are calculated for bimetallic Au–Ir clusters (−3.21 up to −5.69 eV). However, weaker Eads values are calculated for Au clusters (ranging from −0.66 to −2.07 eV). As a general trend, we demonstrate that for supported Au–Ir clusters on TiO2(101), those Ir atoms preferentially occupy cluster-oxide interface positions while acting as anchor sites for the Au atoms. The overall geometric arrangements of the putative global minima configurations define O2 adsorption and dissociation, particularly involving the monometallic Au5 and Ir5 as well as the bimetallic Au2Ir3 and Au3Ir2 supported clusters. Spontaneous O2 dissociation is observed on both Ir5 and on the Ir-metallic part of Au3Ir2 and Au2Ir3 supported clusters. This is in sharp contrast with supported Au5, where a large activation energy is needed (1.90 eV). Interestingly, for Au5, we observe that molecular O2 adsorption is favorable at the cluster/oxide interface, followed by a smaller dissociation barrier (0.71 eV). From a single cluster catalysis point of view, our results have strong implications in the ongoing understanding of oxide supported bimetallic while providing a useful first insight into the continuous in silico design of novel subnanometer catalysts.
Intraspecific hybridisation of an invasive lizard on Lord Howe Island
Authors: Chaplin Kirilee , Smith Date Katie , Bray Rebecca D. , Miller Kimberly A. , Lutz Maiko L. , Razeng Emma , Thompson Michael B. , Chapple David G. 
Published: August 2022

Human-mediated dispersal of animals often acts to bring populations that have been separated for substantial periods of evolutionary time (e.g. millions of years) in their native range into contact in their introduced range. Whether these taxa successfully interbreed in the introduced range provides information on the strength of reproductive isolation amongst them. The invasive delicate skink (Lampropholis delicata) has been accidentally introduced to Lord Howe Island from four genetically divergent (>2 million years) regions of the species’ native range in eastern Australia. We used mitochondrial DNA and microsatellite data to investigate whether the individuals from four of the native-range source regions are interbreeding on Lord Howe Island. Our analyses indicate that intraspecific hybridisation among individuals from all four native-range source regions is occurring. Although there is little evidence for hybrids in the northern end of Lord Howe Island (proportion of hybrids: 0–0.02; n = 31), there is a high proportion of hybrids in the central (0.33–0.69; n = 59) and southern regions (0.38–0.75; n = 8) of the island. Given the strong evidence for interbreeding among all four native-range source regions examined, and the relatively minor morphological, life-history and phenotypic variation among them, we suggest that the delicate skink should continue to be treated as a single, widespread, but variable species.
A void in the Hubble tension? The end of the line for the Hubble bubble
Authors: Camarena David , Marra Valerio , Sakr Ziad , Clarkson Chris 
Published: August 2022

Abstract
The Universe may feature large-scale inhomogeneities beyond the standard paradigm, implying that statistical homogeneity and isotropy may be reached only on much larger scales than the usually assumed ∼100 Mpc. This means that we are not necessarily typical observers and that the Copernican principle could be recovered only on super-Hubble scales. Here, we do not assume the validity of the Copernican principle and let cosmic microwave background, baryon acoustic oscillations, type Ia supernovae, local H
0, cosmic chronometers, Compton y-distortion and kinetic Sunyaev–Zeldovich observations constrain the geometrical degrees of freedom of the local structure, which we parametrize via the ΛLTB model—basically a non-linear radial perturbation of a FLRW metric. In order to quantify if a non-Copernican structure could explain away the Hubble tension, we pay careful attention to computing the Hubble constant in an inhomogeneous Universe, and we adopt model selection via both the Bayes factor and the Akaike information criterion. Our results show that, while the ΛLTB model can successfully explain away the H
0 tension, it is favored with respect to the ΛCDM model only if one solely considers supernovae in the redshift range that is used to fit the Hubble constant, that is, 0.023 < z < 0.15. If one considers all the supernova sample, then the H
0 tension is not solved and the support for the ΛLTB model vanishes. Combined with other data sets, this solution to the Hubble tension barely helps. Finally, we have reconstructed our local spacetime. We have found that data are best fit by a shallow void with δ
L ≈ −0.04 and

r

L

out

≈
300

Mpc, which, interestingly, lies on the border of the 95% credible region relative to the standard model expectation.