bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phylogeny of the genus Dolichopus Latreille, 1796 and testing for phylogenetic signal in morphological characters and morphometric data
Authors: Chursina Mariya A. , Grichanov Igor Ya. 
Published: February 2022

AbstractFour groups of characters were used to evaluate phylogenetic relationships among 50 species of the genus Dolichopus: 810 nucleotide characters (for cytochrome oxidase I), 18 continuous characters generated from a geometric morphometric analysis of wing shape, 12 relative characters of the leg morphometry and 42 traditional morphological characters. Subsequently, the common database was used to construct a phylogenetic genus tree and to study the presence of a phylogenetic signal in each group. In this study it was shown that the following characters have a significant phylogenetic signal: the thickening of the costal vein at the insertion point with R1, the color of the fore coxa, the presence of male secondary sexual characters on the forelegs, the color of the femora, the presence of long cilia on the hind femora, and the color of the lower postocular cilia. Traits of male wing shape, such us the relative position of the apex of M1+2, the location of the posterior cossvein, the origin of the radial veins, and the position of the anal vein base, also showed a high phylogenetic signal. In addition, in males, the relative lengths of the first segment of the fore and mid tarsi showed a clear correlation with molecular data, which were interconnected with the presence of males leg modifications. In females, morphometric traits exhibited a less significant phylogenetic signal than in males, although, in most cases, the same traits evinced a high phylogenetic signal.StatementsWe (corresponding authors) certify that we have participated sufficiently in the conception and design of this work and the analysis of the data (wherever applicable), as well as the writing of the manuscript, to take public responsibility for it. We believe the manuscript represents valid work. We have reviewed the final version of the manuscript and approve it for publication. Neither has the manuscript nor one with substantially similar content under my authorship been published nor is being considered for publication elsewhere, except as described in an attachment. Furthermore, we attest that we will produce the data upon which the manuscript is based for examination by the editors or their assignees, if requested.The present paper has not been submitted to another journal. All co-authors are aware of the present submission. All co-authors agree to the publication. The work was funded by RFBR and NSFC according to the research project No 20-54-53005.
Sequence-directed RNA remodeling within a topologically complex RNP substrate
Authors: Cruz Victor Emmanuel , Sekulski Kamil , Peddada Nagesh , Sailer Carolin , Balasubramanian Sahana , Weirich Christine S. , Stengel Florian , Erzberger Jan P. 
Published: February 2022

AbstractDEAD-box ATPases are ubiquitous enzymes essential in all aspects of RNA biology. However, the limited in vitro catalytic activities described for these enzymes is at odds with their complex cellular roles, most notably in driving large-scale RNA remodeling steps during the assembly of ribonucleoproteins (RNPs). We describe cryo-EM structures of 60S ribosomal biogenesis intermediates that reveal how context-specific RNA unwinding by the DEAD-box ATPase Spb4 results in extensive, sequence-directed remodeling of rRNA secondary structure. Multiple cis and trans interactions stabilize a post-catalytic, high-energy intermediate that drives the organization of the root helix structure within rRNA domain IV. This mechanism explains how limited strand separation by DEAD-box ATPases is leveraged to provide non-equilibrium directionality and ensure efficient and accurate RNP assembly.
Loss of intracerebellar heterogeneity and selective vulnerability in Spinocerebellar ataxia type 1 neurodegeneration
Authors: Hamel Katherine , Moncada Emmanuel Labrada , Sheeler Carrie , Rosa Juao-Guilherme , Gilliat Stephen , Zhang Ying , Cvetanovic Marija 
Published: February 2022

AbstractRegional heterogeneity of neurons and glia is a key feature of the brain, yet the effect of disease on heterogeneity and its relationship with selective neuronal vulnerability remains poorly understood.Using region-specific RNA sequencing, we identified a large number of differentially expressed genes (DEGs) across distinct regions of the cerebellar cortex, supporting the notable intrinsic regional transcriptional heterogeneity of the healthy cerebellum. Further, we used fiber photometry to identify regional physiological differences in the activity of Purkinje cells (PCs) during self-motivated, unrestrained walking and non-walking states. In the inherited cerebellar neurodegenerative disease Spinocerebellar ataxia type 1 (SCA1), patients exhibit preferential degeneration of the posterior cerebellum, suggesting regionally selective vulnerability. We demonstrated that in a mouse model of SCA1 the Purkinje cells and glia residing in the posterior vermis of cerebellum also undergo earlier and more severe pathology. Intriguingly, the intrinsic transcriptional heterogeneity of anterior and posterior cerebellum seen in healthy mice was diminished in SCA1 mice. This disruption was also demonstrated via fiber photometry, where we found notable impacts in PC activity in the posterior cerebellum as well as loss of regional differences in PC activity during self-motivated, unrestrained walking, and non-walking states in SCA1 mice. Our findings indicate regionally distinct mechanisms of pathogenesis across cerebellar regions that result in reduced intracerebellar heterogeneity.
LUBAC is required for RIG-I sensing of RNA viruses
Authors: Teague Helena C , Lefevre Charlotte , Rieser Eva , de Miguel Diego , Patricio Daniel , Oliveira Marisa , Mansur Daniel S , Irigoyen Nerea , Walczak Henning , Ferguson Brian J 
Published: February 2022

AbstractThe ability of cells to mount an interferon response to virus infections depends on intracellular nucleic acid sensing pattern recognition receptors (PRRs). RIG-I is an intracellular PRR that binds short double stranded viral RNAs to trigger MAVS-dependent signalling. The RIG-I/MAVS signalling complex requires the coordinated activity of multiple kinases and E3 ubiquitin ligases to activate the transcription factors that drive type I and type III interferon production from infected cells. The linear ubiquitin chain assembly complex (LUBAC) regulates the activity of multiple receptor signalling pathways in both ligase-dependent and -independent ways. Here, we show that the three proteins that constitute LUBAC have separate functions in regulating RIG-I signalling. Both HOIP, the E3 ligase capable of generating M1-ubiquitin chains, and LUBAC accessory protein HOIL-1 are required for viral RNA sensing by RIG-I. The third LUBAC component, SHARPIN, is not required for RIG-I signalling. These data cement the role of LUBAC as a positive regulator of RIG-I signalling and as an important component of antiviral innate immune responses.
Accurate and simple FXN-GAA repeats (Friedreich ataxia loci) estimation by long read targeted sequencing
Authors: Sharma Pooja , Uppili Bharathram , Ahmad Istaq , Sahni Shweta , Vivekananda A , Faruq Mohammed 
Published: February 2022

AbstractFriedreich ataxia, an autosomal recessive disorder is caused by tandem GAA nucleotide repeats expansion in intron 1 of the FXN (frataxin gene). The GAA repeats above 66 in length are considered as pathogenic and commonly occurring repeats are 600-1200. Clinically the spectrum of the features is confined mainly to the neurological tissue, however, cardiomyopathy and diabetes mellitus has been observed in 60% and 30% of the subjects. The accurate detection of GAA repeats count is of utmost importance for clinical genetic correlation as no study has attempted an approach which is of high throughput nature and defines the sequence of GAA repeats. Largely, the method for detection of GAA repeats so far is either conventional PCR based screening and southern blot which is the gold standard method. We describe for the first time a method of long read sequencing wherein we utilized approach of long range targeted amplification of FXN-GAA repeats and sequencing on oxford MinION platform. We were able to achieve the successful amplification of GAA repeats ranging from 180-1200 at 250x coverage. The total throughput achievable for 96 samples can be less than 24 hours on one flow cell as per our protocol and is scalable and deployable at clinical day to sequencing.
Conceptualizing the role of blockchain in omnichannel healthcare: a Delphi study
Authors: Sangal Shreya , Nigam Achint , Bhutani Chitrakshi 
Published: February 2022

PurposeThis study aims to identify the challenges in the healthcare industry as it adopts an omnichannel setup in an emerging economy context. Further, the study determines the scope of blockchain in addressing these challenges.Design/methodology/approachThe study uses a qualitative approach to understand the challenges in the omnichannel healthcare industry and know the scope of blockchain in building an omnichannel healthcare system. In the first stage, it did an in-depth analysis of the extant literature, followed by a Delphi study with 24 healthcare experts.FindingsThe study presents the current challenges in the omnichannel healthcare sector in an emerging economy. Further, it develops a novel conceptual framework for blockchain adoption in the omnichannel healthcare industry. The study also presents propositions that will help healthcare service providers enhance decision-making concerning the adoption of blockchain in the healthcare industry.Research limitations/implicationsThe research results may lack generalizability due to the exploratory approach and emerging economies context. Theoretically, in this study, the authors extend the theory of swift trust and organization information processing theory in an omnichannel healthcare context.Practical implicationsThe propositions provided in this paper can help healthcare managers make strategic decisions on the scope of adoption of blockchain for omnichannel healthcare.Originality/valueThis study explores the understudied area of challenges in omnichannel healthcare and the scope of blockchain for omnichannel healthcare in an emerging economy context.
Agreement level of vitamin D intake between food frequency questionnaire and 24-h food recall in young Qatari women
Authors: Ganji Vijay , ElObeid Tahra , Shi Zumin , Bawadi Hiba , Kerkadi Abdelhamid , Moussa Noor , Ali Hoda , Sobeih Alshaimaa 
Published: February 2022

PurposePrevalence of vitamin D insufficiency among young Qatari women is ∼85%. The purpose of the study was to develop a food frequency questionnaire (FFQ) and to assess the degree of agreement between food vitamin D intakes derived from FFQ and 24-h food recall (24HFR) in young Qatari women.Design/methodology/approachA vitamin D-centric, 40-item FFQ was developed based on foods consumed in Qatar. In total, 36 Qatari women provided food intakes using FFQ and 24HFR. Vitamin D contents of foods reported in FFQ and 24HFR were computed. Spearman rank correlation was used to evaluate the relation between vitamin D intakes of FFQ and 24HFR. Bland–Altman (BA) plot and quartile comparisons were performed to determine the degree of agreement between food intakes of FFQ and 24HFR.FindingsMedian intakes of vitamin D from FFQ were significantly higher compared to the vitamin D content from 24HFR (213 IU vs 126 IU; p < 0.008). Vitamin D intakes were lower with 24HFR when compared with the intakes of FFQ. There was no significant relationship between food vitamin D intake from FFQ and 24HFR (Spearman rho = 0.16; p < 0.35). In cross classification, ∼64% were assigned to the same or adjacent quartiles. As per BA plot, more than 95% food intakes were within the limits of agreement (LOA) (BA index, 2.8%).Originality/valueThere was a moderate agreement between vitamin D intakes and FFQ and 24HFR. 24HFR should be used with caution in assessing the habitual food vitamin D intake because of limited sources of the vitamer in Qatari cuisine. The FFQ is suitable for estimating the food vitamin D intake in young Qatari women.
The relationship between energy consumption and economıc growth in the G7 countries: the time-varying asymmetric causality analysis
Authors: Tuna Gülfen , Tuna Vedat Ender , Aghalarova Mirsariyya , Atasoy Ahmet Bülent 
Published: February 2022

Purpose
This study aims to reveal new information about the relationship between energy consumption and economic growth for the time-varying causality.

Design/methodology/approach
Economic growth and renewable and nonrenewable energy consumption data of the G7 countries (Canada, France, Germany, Italy, Japan, the UK and the USA) for the 1980–2016 period were used in the study. The nonasymmetric causality test developed by Hacker and Hatemi-J (2006) and both traditional and time-varying forms of the asymmetric causality test by Hatemi-J (2012) were used as the study method.

Findings
While the study favors feedback hypothesis for renewable energy consumption in the nonasymmetric causality tests in the UK economy, it favors the same hypothesis for nonrenewable energy consumption in the US economy. However, according to the results reported by Hatemi-J (2012), the feedback hypothesis, which is supported for the UK, is supported only in positive shocks, yet not for each period of analysis. Similarly, feedback hypothesis, which is supported in the USA, is supported only in the negative shocks, yet not for each period of analysis.

Originality/value
This study examined that the asymmetric causality relationship between variables can be analyzed in time-varying form. Therefore, whether positive and negative shocks in renewable and nonrenewable energy consumption always provide useful information in estimations about economic growth is analyzed.
Dynamic openness for network-enabled product and process innovation: a panel-data analysis
Authors: Kesidou Effie , Narasimhan Ram , Ozusaglam Serdal , Wong Chee Yew 
Published: February 2022

PurposePrior research on open innovation has not investigated changes in knowledge acquisition strategies of firms over time overlooking how learning from past knowledge acquisition can change subsequent search strategies. Also, prior research has focused principally on product innovation overlooking process innovation. The purpose of the paper is to introduce the concept of dynamic openness, which is defined as temporal changes in external knowledge search strategy. We explore four dynamic openness strategies – closing down, opening up, persistent open and persistent closed – and examine the impact of these strategies on both product and process innovation.Design/methodology/approachThe authors used a panel dataset of 16,021 firms based on five waves (2009–2017) of the UK Community Innovation Survey (UKIS). All models are estimated using firm and year fixed effects (FE) method to control for endogeneity that arises from unobserved heterogeneity. Endogeneity and robustness tests were carried out to ensure the validity of results.FindingsThe results show that firms do use dynamic openness strategies over time leveraging learning from past searches. Specifically, the study indicates that closing down is not an effective strategy for either type of innovation. For process innovation, firms should pursue opening up strategy rather than persistent open strategy, whereas for product innovation firms could pursue either strategy, highlighting important contextual differences.Originality/valueThe paper contributes to the literature on knowledge acquisition in open innovation: (1) by theorizing the underlying reasons – learning from past collaborations, absorptive capacity and external knowledge heterogeneity – why firms pursue one dynamic openness strategy over another and (2) by extending literature by delineating the dynamic openness strategies that firms should pursue in process innovation vs product innovation.
Increasing competitive performance through effective use of performance management systems
Authors: Al-Jaradi Majid H. , de Waal André , Al-Hadramy Ahmed M. 
Published: February 2022

PurposePrivate telecommunication companies in Yemen face huge challenges to improve their competitive position. Many of them suffer from performance management systems (PMS) that are not aligned nor integrated and do not give adequate support. This research aims at identifying the current state and quality of PMS in Yemeni private telecom companies and developing recommendations that will assist in improving their performance and competitive position.Design/methodology/approachAs research tools, the performance management analysis – used to measure the quality of a PMS – and the high performance organization (HPO) framework – used to measure the quality of an organization and thereby its ability to achieve sustainable high competitive performance – are applied at three Yemeni private telecom companies.FindingsThere is a considerable performance gap between the actual and the ideal PMS in the Yemeni private telecom companies; this performance gap is highly correlated with competitive performance in a negative relationship. Both the structural and behavioral dimensions’ performance gaps have a significant impact on competitive performance, with the impact of the behavioral dimensions being considerably higher than that of the structural dimensions.Originality/valueThe current academic literature on HPOs and PMS in Yemen is scarce. This study adds knowledge to these areas, and thus provides a basis for further study. This research results also help managers of the Yemeni private telecom companies to take strategic action to redesign and implement new and improved PMS to increase their competitive performance.
Omnichannel retailing and post-pandemic recovery: building a research agenda
Authors: Salvietti Giada , Ziliani Cristina , Teller Christoph , Ieva Marco , Ranfagni Silvia 
Published: February 2022

PurposeThe study aims to propose a comprehensive overview of the Omnichannel phenomenon by identifying its theoretical foundations as well as future research directions.Design/methodology/approachIn order to systematize Omnichannel-centered contributions and identify future research directions for post-Covid-19, this study adopted a mixed-method study, combining a systematic literature review, a bibliometric co-citation analysis and a panel discussion by field experts.FindingsIn Study 1, the authors traced extant literature on Omnichannel back to its theoretical foundations, which led to the identification of four research areas in which the concept of Omnichannel is rooted. Contributions pertaining to the aforesaid research areas were discussed and submitted to a panel of experts (Study 2) after the lockdown periods. The experts gave various insights into both the past and future of Omnichannel research. Finally, a framework synthesizing theoretical foundations of Omnichannel, literature gaps and opportunities for future research is provided.Originality/valueTo our knowledge, this is the first attempt to combine mixed methods study in Omnichannel research and to involve a panel of experts in order to discuss the findings of a literature review and evaluate future research directions. This choice allowed us to investigate both incumbent academic and managerial challenges raised by Omnichannel and to provide guidance for the post-pandemic recovery.
Identifying research trends of machine learning in business: a topic modeling approach
Authors: Pramanik Paritosh , Jana Rabin K. 
Published: February 2022

Purpose
This paper aims to discuss the suitability of topic modeling as a review method, identifies and compares the machine learning (ML) research trends in five primary business organization verticals.

Design/methodology/approach
This study presents a review framework of published research about adopting ML techniques in a business organization context. It identifies research trends and issues using topic modeling through the Latent Dirichlet allocation technique in conjunction with other text analysis techniques in five primary business verticals – human resources (HR), marketing, operations, strategy and finance.

Findings
The results identify that the ML adoption is maximum in the marketing domain and minimum in the HR domain. The operations domain witnesses the application of ML to the maximum number of distinct research areas. The results also help to identify the potential areas of ML applications in future.

Originality/value
This paper contributes to the existing literature by finding trends of ML applications in the business domain through the review of published research. Although there is a growth of research publications in ML in the business domain, literature review papers are scarce. Therefore, the endeavor of this study is to do a thorough review of the current status of ML applications in business by analyzing research articles published in the past ten years in various journals.
Notable Trade Book Lesson Plan Glass Slipper, Gold Sandal: A Worldwide Cinderella Written by Paul Fleischman and Illustrated by J. Paschkis
Authors: Baylen Danilo M. 
Published: February 2022

Glass Slipper, Gold Sandal: A Worldwide Cinderella
draws from a variety of folk traditions, including images and texts, to put together a version of a Cinderella story. The writing blends various elements from Cinderella stories from twenty countries and places to create a tale full of culture-specific images and perspectives. The book illustrates the diversity in people’s lives, which is continuously connected through our similarities and differences. The book is appropriate to use as a hook supporting delivery of a social studies curriculum, and to introduce social studies concepts in third and fourth grade classrooms.
Notable Trade Book Lesson Plan Lost Childhood: My Life In A Japanese Prison Camp During World War II Written by Annelex Hofstra Layson with Herman J. Viola
Authors: Haas Mary E. 
Published: February 2022

Lost Childhood: My Life In A Japanese Prison Camp During World War II
is a memoir. The events of World War II (WWII) took place around the world disrupting the daily lives of children. In school students often examine WWII only from the perspective of their own nation and thereby fail to learn and understand how their lives today were impacted by a war that began 70 years ago and continues to impact the world today. This lesson examines a detailed memoir of Annelex, a child in the Dutch East Indies during WWII and in its immediate aftermath. Annelex describes her fears and how her mother and grandmother helped her overcome uncertainties in living to survive and grow.