bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cohen syndrome in two patients from China
Authors: Gong Jiaoe , Zhang Lily , Long Yanwei , Xiao Bo , Long Hongyu 
Published: September 2022

AbstractBackgroundCohen syndrome (CS; OMIM 216550) is a rare syndrome with evident clinical heterogeneity. The diverse phenotype comprises early‐onset hypotonia and developmental delays, intellectual disabilities, microcephaly, hypermobile joints, neutropenia, myopia, and characteristic facial features. The disease is rarely reported. Vacuolar Protein Sorting 13 Homolog B (VPS13B; OMIM 607817) is the only causative gene of CS.MethodsBlood samples sourced from both siblings and parents were sent to identify mutations by trio‐WES, and changes in the patient's condition were understood through consultation data and follow‐up.ResultsWe reported two siblings affected by developmental delay, microcephaly, intellectual disability, and facial features. The siblings' WES detected compound heterozygous variants in the exon region of VPS13B (NM_017890): c.9337A>T and c.8551A>C.ConclusionTwo individuals were diagnosed with CS by genetic testing and clinical features. In addition, we conduct a brief review of the reports on the Chinese population with CS and reinforce the understanding of the correlation between genotype–phenotype.
Dual‐band full‐duplex antenna with high isolation using differential fed and dual‐polarization
Authors: Prasad D. Venkata Siva , Singh Harsh V. , Tripathi Shrivishal , Paltani Punya P. 
Published: September 2022

AbstractThis study proposes a new design approach for a dual‐band full‐duplex antenna to achieve high interport isolation using the differential fed technique. It consists of a single radiating patch, a differential fedline, and a direct fedline. A slotline‐based balun is used in the design to implement the differential fed, which offers minimum phase and magnitude imbalances to the patch of the antenna. The differential fed and direct‐fed lines are orthogonally connected to the radiating patch to realize dual polarization. Both the dual‐polarization and differential fed techniques help to improve the interport isolation of the antenna. It offers an interport isolation of more than 51 and 53 dB over the entire lower and higher operating bands, resonating at 3.22 and 4.1 GHz with 84 and 110 MHz bandwidths. To validate the proposed antenna, a prototype has been fabricated on an FR‐4 substrate with the dimensions of (1.79 × 1.79 × 0.017)λg (λg is the guided wavelength in the substrate at the lower frequency f1), with measured results consistent well with simulations. The far‐field measurement exhibits that the proposed antenna provides a unidirectional broadside radiation pattern and achieves a minimum cross‐polarization of less than −38 dB in all directions and less than −42 dB in the direction of the main lobe in both E‐ and H‐planes at the resonant frequencies. The antenna has insignificant backward radiation with the front‐to‐back ratio 20 dB when port1 is active and the front‐to‐back ratio 30 dB when port2 is active. Moreover, the proposed antenna design is simple and easy to fabricate as the differential fed is implemented using the slotline‐based balun within the same general purpose FR‐4 substrate layer. This eliminates the need for any additional and separate circuits for differential fed and minimizes the overall volume of the antenna.
Terahertz groove gap waveguide leaky wave antenna
Authors: Hongjian Wang , Min Yi , Minzheng Ma 
Published: September 2022

AbstractA groove gap waveguide (GGW) leaky wave antenna with a wide scan angle in the terahertz (THz) band (430–560 GHz) is presented in this study. The unnecessary tight contact between the top plate and pins of the GGW makes it easy for the fine fabrication and assembly of this THz antenna. Scanning of pointing directions with frequency, together with the low side‐lobe level (SLL), is designed for the pins' heights and intervals as well as the groove cavity width. Measurement results of S11 parameters remain about −20 dB, besides, the antenna scan angle range is 15o within 430–560 GHz, and the gains are also above 15 dB within that working frequency bands.
Realistic modeling of cemented granular materials with a lattice spring model by developing a digital 3D reconstruction approach
Authors: Wei Xin‐Dong , Deng Zhi‐Qiang , Zhao Gao‐Feng 
Published: September 2022

AbstractThree‐dimensional (3D) geometric reconstruction is a fundamental requirement to realistically predict the mechanical behavior of cemented granular materials (CGMs). In this work, a four‐phase geometric reconstruction method for CGMs, involving aggregate, cement, in‐between interfacial transition zone (ITZ), and void phases, is developed by using digital image processing techniques and an optimization algorithm. The reconstruction method includes four steps. (1) The planar outlines of aggregates are extracted from a two‐dimensional (2D) aggregate image (e.g., gravels, pebbles, and crushed stones) based on the image segmentation algorithm. (2) Through spatial geometric transformations on the acquired planar outlines, the 3D aggregates are generated, whose reliability is verified by comparison with those obtained by a 3D scanner. (3) According to the volume ratio of each phase, the initial four‐phase model is reconstructed by randomly placing aggregates into the user‐defined domain with considering the size distribution of aggregates, followed by the generation of the ITZ represented by their surrounding minimum envelope surface, and the insertion of voids in the rest cement phase. (4) The final realistic CGM is reconstructed by optimizing the spatial distribution of the void and cement phases based on a simulated annealing algorithm. Afterwards, the rationality of the reconstructed CGM is verified by comparing two‐point probability functions between the physical model and the reconstructed model. With the aid of a four‐dimensional lattice spring model (4D‐LSM), the feasibility of the reconstructed CGM to reproduce its mechanical behavior is demonstrated by numerical examples and a comparison with existing experimental or other numerical solutions.
Recent Advances in Fuel‐Driven Molecular Switches and Machines
Authors: Benny Renitta , Sahoo Diptiprava , George Ajith , De Soumen 
Published: September 2022

AbstractThe molecular switches and machines arena has entered a new phase in which molecular machines operate under out‐of‐equilibrium conditions using appropriate fuel. Unlike the equilibrium version, the dissipative off‐equilibrium machines necessitate only one stimulus input to complete each cycle and decrease chemical waste. Such a modus operandi would set significant steps towards mimicking the natural machines and may offer a platform for advancing new applications by providing temporal control. This review summarises the recent progress and blueprint of autonomous fuel‐driven off‐equilibrium molecular switches and machines.
Fear of progression and its associated factors in parents of children undergoing cancer treatment: A cross‐sectional study
Authors: Yang Yiling , Zhang Yuwei , Liang Lichan , Liao Xiaomei , Meng Jiangnan , Cai Ruiqing , Ye Hongyu , Hu Jiamin , He Xiaofeng , Shi Lei 
Published: September 2022

AbstractObjectiveFear of progression (FoP) is a common psychosocial problem among adult cancer patients, but data on parents of children undergoing cancer treatment are scarce. This study aimed to determine the prevalence of FoP in parents of children undergoing cancer treatment and explore the associated factors.MethodsOverall, 285 parents of children undergoing cancer treatment were recruited from three general hospitals in China. FoP in the parents was assessed using the Chinese version of the Fear of Progression Questionnaire‐parent version (FoP‐Q‐SF/PR). Other questionnaires included the Self‐Compassion Scale, Pittsburgh Sleep Quality Index, Posttraumatic Stress Disorder Checklist‐Civilian Version, and items on socio‐demographic and medical characteristics. Pearson correlation and multiple linear regression analysis were used to identify factors associated with FoP.ResultsA total of 75.1% of the participants showed dysfunctional levels of FoP. The mean FoP‐Q‐SF/PR score was 39.98 (standard deviation = 9.18). Parental FoP was significantly associated with a shorter time since diagnosis, lower levels of self‐compassion, poor sleep quality, and severe posttraumatic stress symptoms (Adjusted R Squared = 0.369, F = 12.838, p < 0.01).ConclusionsFoP is a frequently reported problem among parents of children undergoing cancer treatment. In this cohort, parents of children with a shorter time since cancer diagnosis were at higher risk of suffering from FoP. Interventions to enhance self‐compassion, improve sleep quality, and mitigate posttraumatic stress symptoms may help with the psychological adjustment and well‐being of parents whose children are undergoing cancer treatment.
The impact of prehabilitation interventions on affective and functional outcomes for young to midlife adult cancer patients: A systematic review
Authors: Scriney Aideen , Russell Amy , Loughney Lisa , Gallagher Pamela , Boran Lorraine 
Published: September 2022

AbstractObjectiveCancer remains one of the most enduring health crises of the modern world. Prehabilitation is a relatively new intervention aimed at preparing individuals for the stresses associated with treatment from diagnosis. Prehabilitation can include exercise, psychological and nutrition‐based interventions. The present systematic review aimed to assess the efficacy of prehabilitation on affective and functional outcomes for young to midlife adult cancer patients (18–55 years). Outcomes of interest included prehabilitation programme composition, duration, mode of delivery and measures used to determine impact on affective and functional outcomes.MethodsThe following databases were searched with controlled and free text vocabulary; Psychological Information database (PsychINFO), Culmunated Index to Nursing and Allied Health Literature (CINAHL), Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica Database (EMBASE) and Public MEDLINE (PubMed). Abstract and full‐text screening was conducted with a secondary reviewer and final texts were subject to risk of bias analysis.ResultsThirteen texts were included at full‐text. These included data of 797 prehabilitation participants (mean age 53 years) and a large representation of female participants (71% average). Evidence was found for the efficacy of psychological prehabilitation for anxiety reduction. Prehabilitation did not significantly affect health related quality of life. Findings moderately supported the therapeutic validity of exercise prehabilitation for functional outcomes, both in terms of clinical and experimental improvement with respect to the quality of evidence. Variation between all prehabilitation types was observed. There was insufficient evidence to support the efficacy of psychological prehabilitation on stress, distress or depression.ConclusionImplications for future research are highlighted and then discussed with respect to this young to midlife age group.
α‐Asarone attenuates chronic sciatica by inhibiting peripheral sensitization and promoting neural repair
Authors: Zhang Di , Li Xin , Jing Bei , Chen Zhenni , Shi Huimei , Zheng Yachun , Chang Shiquan , Sun Jianxin , Zhao Guoping 
Published: September 2022

AbstractThis study explored the therapeutic effect of α‐asarone on chronic sciatica. Thirty‐two Sprague–Dawley (SD) rats were divided into four groups: the sham group, chronic constriction injury (CCI) group, pregabalin group, and α‐asarone group. Hot hyperalgesia was induced after the CCI operation, and α‐asarone was found to relieve chronic neuralgia. Furthermore, α‐asarone reduced IL1β, IL6, TNF‐α, CRP, and LPS levels and increased IL10 levels in serum. α‐Asarone decreased the protein levels of TRPA1, TRPM8, and TRPV1‐4 and the mRNA levels of TRPA1, TRPM8, TRPV1‐4, IL1β, and TNF‐α in dorsal root ganglion neurons. In the sciatic nerve, α‐asarone treatment reduced the number of inflammatory cells and promoted the proliferation of Schwann cells, favouring recovery of the nerve structure. In cellular experiments, LPS induced Schwann cell apoptosis via TLR4/p38MAPK signalling; α‐asarone attenuated LPS‐induced Schwann cell apoptosis by decreasing TLR4, p‐p38MAPK, cleaved‐caspase3, and cleaved‐caspase7 levels and increasing Bcl‐2 and Bcl‐xl expression. Overall, these findings suggest that α‐asarone relieves chronic sciatica by decreasing the levels of inflammatory factors, inhibiting peripheral sensitization, and favouring the repair of damaged nerves.
Multiwalled Carbon Nanotubes Decorated with Layered Double Hydroxides as Multifunctional Fillers for Polypropylene
Authors: Nagendra Baku , Leuteritz Andreas , Bhoje Gowd E. 
Published: September 2022

AbstractThe multiwalled carbon nanotubes (CNTs) decorated with exfoliated and fragmented layered double hydroxides (CNT‐LDH hybrids) were used as multifunctional nanofillers for isotactic polypropylene (iPP). Under similar experimental conditions, iPP/CNTs and iPP/LDH nanocomposites were also prepared. Compared to neat iPP, both CNT‐LDH hybrids and LDH showed effective nucleation ability for iPP. Hybrid CNT‐LDH fillers are found to improve the thermal stability and flame retardancy of iPP significantly even with minimum loadings (1 wt% CNTs + 1 wt% LDH) compared to the individual fillers. The highest 50 % weight loss temperature was observed for iPP/CNT‐LDH nanocomposites. The nanocomposite prepared with 2 wt% of CNT‐LDH hybrid fillers showed a reduction of heat release rate (HRR) of 59 %, which is much higher than the nanocomposites prepared with 2 wt% of CNTs (30.5 %) and 2 wt% of LDH (19 %). The limiting oxygen index value of iPP is 16.5 % and it increases to 23 % for iPP/CNT‐LDH nanocomposites. We have shown that the synergetic effect between CNTs and LDH can surpass individual nanofillers as effective flame retardants due to the capability of formation of a jammed network in the polymer matrix and effective char formation to restrict the transport of volatile compounds during the burning of the polymer.
Synthesis and QSAR Analysis of Diaryl Ethers and Their Analogues as Potential Antiviral Agents
Authors: Nikolova Ivanka , Slavchev Ivaylo , Zagranyarska Irena , Nikolova Nadya , Vilhelmova Neli , Stoyanova Adelina , Grozdanov Petar , Mukova Lucia , Galabov Angel S. , Lessigiarska Iglika , Tsakovska Ivanka , Dobrikov Georgi M. 
Published: September 2022

AbstractA series of 42 diarylethers and their analogues were synthesized. All compounds were tested in vitro against six viruses. Two diarylethers in this series demonstrated selective and remarkable activity toward Human Coronavirus OC43 and Human Adenovirus 5 (SI 97.4 and 99.7, respectively). QSARs for the investigated antiviral activities were explored. The analysis was based on a large library of 113 diarylethers and their analogues comprising the compounds reported in this paper, as well as compounds previously synthesized and tested by us. Statistically reliable regression and discriminant models were derived which revealed structural and physicochemical features of the compounds important for the antiviral activities. These models may be used as guidance for synthesis of lead compounds with promising antiviral activity toward the investigated viruses.
Assessing owners' readiness to change their behaviour to address their companion animal's obesity
Authors: Sutherland Katja A. , Coe Jason B. , O'Sullivan Terri L. 
Published: September 2022

AbstractBackgroundOwner behaviour change in relation to management is critical for successful pet weight loss. The stages of change (SOC) can be used to conceptualise the process of intentional behaviour change. Clients may be more likely to make successful changes when practitioners use communication techniques appropriate for a client's current stage. The objective of this cross‐sectional study was to assess pet owners’ SOC in relation to managing the weight of their overweight or obese pet.MethodsAn online questionnaire targeting dog and cat owners was distributed via snowball sampling. A total of 532 questionnaires were included in the analysis. Of these, 153 participants (28.8%) self‐identified their pet's body condition score (BCS) as greater than 5 (on a nine‐point scale). An adapted University of Rhode Island Change Assessment scale was completed by 119 of these participants (77.8%) to assess their readiness to change related to managing their overweight or obese pet.ResultsMost participants were scored in the precontemplation (52.1%) and contemplation (42%) stages, where readiness to change is low. Owner assessments likely resulted in underestimation of pets’ BCS.ConclusionThe results offer preliminary insight into the SOC of owners who identify their pets as overweight or obese. Developing tools to assess and understand owners’ readiness to change may be useful in informing veterinary professionals’ communication approaches when engaging in weight management conversations.
Use of low‐dose quetiapine increases the risk of major adverse cardiovascular events: results from a nationwide active comparator‐controlled cohort study
Authors: Højlund Mikkel , Andersen Kjeld , Ernst Martin T. , Correll Christoph U. , Hallas Jesper 
Published: September 2022

At standard doses used for schizophrenia or bipolar disorder, quetiapine has been associated with weight gain and increased levels of triglycerides, to­tal cholesterol and low‐density lipoprotein (LDL) cholesterol, which are risk factors for cardiovascular morbidity and mortality. However, this drug is also commonly used off‐label at low doses for anxiolytic or hypnotic purposes, and its cardiovascular safety at these doses is unknown. We aimed to assess the risk of major adverse cardiovascular events with use of low‐dose quetiapine compared to use of Z‐drug hypnotics in a nationwide, active comparator‐controlled cohort study. The cohort included new users of either drugs in Denmark from 2003 to 2017, aged 18‐85 years, without history of ischemic stroke, myocardial infarction, cancer, and severe mental illness. The main outcome was the occurrence of major adverse cardiovascular events, defined as non‐fatal myocardial infarction or ischemic stroke, or death from cardiovascular causes. Selective serotonin reuptake inhibitors (SSRIs) were used as an alternative comparator in sensitivity analyses. Altogether, we compared 60,566 low‐dose quetiapine users with 454,567 Z‐drug users, followed for 890,198 person‐years in intent‐to‐treat analysis, and 330,334 person‐years in as‐treated analysis. In intention‐to‐treat analysis, low‐dose quetiapine was associated with an increased risk of major adverse cardiovascular events (adjusted hazard ratio, aHR=1.13, 95% CI: 1.02‐1.24, p=0.014) and cardiovascular death (aHR=1.26, 95% CI: 1.11‐1.43, p<0.001). In as‐treated analysis, continuous low‐dose quetiapine use was associated with increased risk of major adverse cardiovascular events (aHR=1.52, 95% CI: 1.35‐1.70, p<0.001), non‐fatal ischemic stroke (aHR=1.37, 95% CI: 1.13‐1.68, p=0.002) and cardiovascular death (aHR=1.90, 95% CI: 1.64‐2.19, p<0.001). The risk of major adverse cardiovascular events was greater in women (aHR=1.28, p=0.02) and those aged ≥65 years at initiation (aHR=1.24, p<0.001). Compared to SSRIs, low‐dose quetiapine use was associated with an increased risk of major adverse cardiovascular events (aHR=1.42, p<0.001), non‐fatal ischemic stroke (aHR=1.27, p=0.0028) and cardiovascular death (aHR=1.72, p<0.001). So, we conclude that the use of low‐dose quetiapine is associated with an increased risk of major adverse cardiovascular events, especially in women and the elderly. On the basis of these findings, we suggest that use of off‐label low‐dose quetiapine for sedative or hypnotic purposes should be discouraged.
Privacy-Preserving Techniques for Trustworthy Data Sharing: Opportunities and Challenges for Future Research
Authors: Dutkiewicz Lidia , Miadzvetskaya Yuliya , Ofe Hosea , Barnett Alan , Helminger Lukas , Lindstaedt Stefanie , Trügler Andreas 
Published: September 2022

AbstractOne of the foundations of data sharing in the European Union (EU) is trust, especially in view of the advancing digitalization and recent developments with respect to European Data Spaces. In this chapter, we argue that privacy-preserving techniques, such as multi-party computation and fully homomorphic encryption, can play a positive role in enhancing trust in data sharing transactions. We therefore focus on an interdisciplinary perspective on how privacy-preserving techniques can facilitate trustworthy data sharing. We start with introducing the legal landscape of data sharing in the EU. Then, we discuss the different functions of third-party intermediaries, namely, data marketplaces. Before giving a legal perspective on privacy-preserving techniques for enhancing trust in data sharing, we briefly touch upon the Data Governance Act (DGA) proposal with relation to trust and its intersection with the General Data Protection Regulation (GDPR). We continue with an overview on the technical aspects of privacy-preserving methods in the later part, where we focus on methods based on cryptography (such as homomorphic encryption, multi-party computation, private set intersection) and link them to smart contracts. We discuss the main principles behind these methods and highlight the open challenges with respect to privacy, performance bottlenecks, and a more widespread application of privacy-preserving analytics. Finally, we suggest directions for future research by highlighting that the mutual understanding of legal frameworks and technical capabilities will form an essential building block of sustainable and secure data sharing in the future
Common European Data Spaces: Challenges and Opportunities
Authors: Scerri Simon , Tuikka Tuomo , de Vallejo Irene Lopez , Curry Edward 
Published: September 2022

AbstractCommon European data sharing spaces are essential for the implementation of the European digital market. This chapter addresses the challenges and opportunities of Data Spaces identified by the Big Data Value Association community. It brings forward five independent goals, convergence, experimentation, standardization, deployment, and awareness, each targeted toward specific stakeholders in the data sharing ecosystem and presents a timeframe when the goals should take place. Furthermore, we have proposed actions based on BDVA recommendations and mapped them over the five goals.
Connecting Data Spaces and Data Marketplaces and the Progress Toward the European Single Digital Market with Open-Source Software
Authors: Zappa Achille , Le Chi-Hung , Serrano Martín , Curry Edward 
Published: September 2022

AbstractIn this book chapter, recent advances in the development and implementation of open-source software technologies and information management systems to support the progression of the data economy by means of data operations and data offering descriptions are introduced. The management of controlled registries, mapping of information using metadata aggregation, interfaces among components, links of data and actors, discovery and retrieval of data, compiling smart contracts, and other core operations are introduced. This chapter contributes to the state of the art by providing the definition, creation, and collection of data-driven marketplaces that, by design, look at sharing and exchanging data using a common description framework called i3-MARKET. i3-MARKET’s main design objectives are to support the sharing data assets, execute operations, and provide API services and generally all the security-related functionalities relying on data details, credentials, contracts, and pricing. i3-MARKET also uses a sharing semantic model to facilitate the work with people in improving and maintaining the models for the present and future. The i3-MARKET described in the chapter introduces the concept of a backplane architecture as a support tool that aims to innovate the data market industry providing solutions and support in developing building blocks to overcome the barriers to interoperable and integrative data using trusted, federated, and decentralized software components.