bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Phubbing Scale (PS-8) in the Portuguese population: psychometric properties
Authors: García-Castro F. Javier , Abreu Ana Maria , Rando Belén , Blanca María J. 
Published: March 2022

AbstractPhubbing is defined as ignoring other individuals by using a mobile phone during a face-to-face conversation. The Phubbing Scale (PS) was developed to assess this practice. In this study, we analyze the psychometric properties of the 8-item version of the PS (PS-8) in the Portuguese population, providing validity evidence based on internal structure and on relationships with other variables, and examining item properties, reliability, and measurement invariance across gender. Participants were 391 Portuguese adults (132 men, 259 women) who completed a battery of questionnaires. Confirmatory factor analysis yielded satisfactory goodness-of-fit indices for the two-factor structure (communication disturbance and phone obsession), which was invariant across gender. Item homogeneity and reliability of factor scores (McDonald’s omega) were satisfactory. Validity evidence based on relationships with other variables was provided by positive associations with time spent on the Internet on weekdays and at the weekend, time spent on social networking sites, number of social networks used, Internet addiction, problematic mobile phone use, Facebook intrusion, fear of missing out, and depression. These associations show the addictive component of phubbing and its relationship with mental health. The PS-8 is a short and easy-to-administer scale with adequate psychometric properties for measuring phubbing in the Portuguese population.
Off-task social media multitasking during class: determining factors and mediating mechanism
Authors: Deng Liping , Zhou Yujie , Hu Qingchun 
Published: March 2022

AbstractFramed by social learning theory, the study examines a set of personal and social factors determining off-task social media multitasking inside university classrooms. We aim to clarify the relationships between social media multitasking and self-efficacy, intrinsic motivation, multitasking preference as well as peer distraction, and to elucidate the interactive relationships between these factors. Questionnaire data from 203 university students in China show that academic self-efficacy fully mediates the association between intrinsic motivation and off-task multitasking. Moreover, multitasking preference partially mediates the association between peer distraction and off-task multitasking during class time. The findings of the study contribute to a deeper understanding of why students multitask during class, which can inform the development of strategies for combating social media distraction and enhancing students’ learning engagement.
Identification and mapping of QTL associated with some traits related for drought tolerance in wheat using SSR markers
Authors: Khaled Khaled Adly Mohamed , Habiba Rehab Mohamed Mohamed , Bashasha Jamila Abdelhafeeth , El-Aziz Mohamed Hassan Abd 
Published: March 2022

Abstract
Background
Wheat is the most important crop around the world. Drought stresses affect wheat production and their characterization. Most of the traits that are affected by drought are quantitative traits, so detection of the quantitative trait’s loci (QTLs) related to these traits is very important for breeder and wheat producers. In this trend, 285 F2 individuals from crosses between four bread wheat genotypes (Triticum aestivum L.), i.e., Sakha93, Sids1, Sakha94, and Gemmiza9, were used for identified QTLs associated with plant height (PH) and leaf wilting (LW). Single marker analysis and composite interval mapping (CIM) were used.

Results
A total of 116 QTLs loci were detected which covered 19 chromosomes out of the 21 chromosomes of wheat. PH and LW had 74 and 42 QTLs loci, respectively. On the other hand, chromosome 7A showed to bear the highest number of QTLs loci (15 loci). While chromosome 1A beard the highest number of QTLs loci related to PH (10 loci), chromosome 2B and 7A beard the highest number of QTLs related LW. We highly recommend our finding to help breeders in wheat breeding programs to improve plant height and leaf wilting.

Conclusion
Our investigation concluded that SSR markers have high efficiency in the identification of QTLs related to abiotic stress; also the CIM method had more advanced priority for QTLs mapping.
Effect of tax dynamics on linearly growing processes under stochastic resetting: A possible economic model
Authors: Santra Ion 
Published: March 2022

AbstractWe study a system ofNagents, whose wealth grows linearly, under the effect of stochastic resetting and interacting via a tax-like dynamics —all agents donate a part of their wealth, which is, in turn, redistributed equally among all others. This mimics a socio-economic scenario where people have fixed incomes, suffer individual economic setbacks, and pay taxes to the state. The system always reaches a stationary state, which shows a trivial exponential wealth distribution in the absence of tax dynamics. The introduction of the tax dynamics leads to several interesting features in the stationary wealth distribution. In particular, we analytically find that an increase in taxation for a homogeneous system (where all agents are alike) results in a transition from a society where agents are most likely poor to another where rich agents are more common. We also study inhomogeneous systems, where the growth rates of the agents are chosen from a distribution, and the taxation is proportional to the individual growth rates. We find an optimal taxation, which produces a complete economic equality (average wealth is independent of the individual growth rates), beyond which there is a reverse disparity, where agents with low growth rates are more likely to be rich. We consider three income distributions observed in the real world and show that they exhibit the same qualitative features. Our analytical results are in theN → ∞limit and backed by numerical simulations.
Proteomic Profiles of Body Mass Index and Waist-to-Hip Ratio and Their Role in Incidence of Diabetes
Authors: Bao Xue , Xu Biao , Yin Songjiang , Pan Jingxue , Nilsson Peter M , Nilsson Jan , Melander Olle , Orho-Melander Marju , Engström Gunnar 
Published: March 2022

Abstract

Context
It is unclear to what extent the plasma proteome of abdominal fat distribution differs from that of body mass index, and whether the differences have clinical implications.

Objective
To evaluate the difference between the plasma proteomic profiles of body mass index (BMI) and waist-to-hip ratio (WHR), and then examine the identified BMI- or WHR-specific proteins in relation to incidence of diabetes.

Methods
Data were obtained from the Malmö Diet and Cancer-Cardiovascular Cohort study in the general community. Participants (n = 4203) with no previous diabetes (aged 57.2 ± 6.0 years, 37.8% men) were included. Plasma proteins (n = 136) were measured by the Proseek proximity extension method. BMI- and WHR-specific proteins were identified at baseline using a 2-step iterative resampling approach to optimize internal replicability followed by β coefficient comparisons. The identified proteins were considered internally replicated and were then studied in relation to incident diabetes by Cox proportional hazards regression analysis. The main outcome measure was incident diabetes over a mean follow-up of 20.3 ± 5.9 years.

Results
After excluding 21 overlapping proteins and proteins that did not show significantly different associations with BMI vs WHR, 10 internally replicated proteins were found to be specific to BMI, and 22 were found to be specific to WHR (false discovery rate-adjusted P &lt; .05). Of the WHR-specific proteins, 18 remained associated with diabetes risk after multivariate adjustments, whereas none of the BMI-specific proteins showed associations with diabetes risk.

Conclusion
Abdominal fat distribution was associated with some unique characteristics of the plasma proteome that potentially could be related to its additional risk of diabetes beyond general obesity.
Traip controls mushroom body size by suppressing mitotic defects
Authors: O'Neill Ryan S. , Rusan Nasser M. 
Published: March 2022

ABSTRACT
Microcephaly is a failure to develop proper brain size and neuron number. Mutations in diverse genes are linked to microcephaly, including several with DNA damage repair (DDR) functions; however, it is not well understood how these DDR gene mutations limit brain size. One such gene is TRAIP, which has multiple functions in DDR. We characterized the Drosophila TRAIP homolog nopo, hereafter traip, and found that traip mutants (traip−) have a brain-specific defect in the mushroom body (MB). traip− MBs were smaller and contained fewer neurons, but no neurodegeneration, consistent with human primary microcephaly. Reduced neuron numbers in traip− were explained by premature loss of MB neuroblasts (MB-NBs), in part via caspase-dependent cell death. Many traip− MB-NBs had prominent chromosome bridges in anaphase, along with polyploidy, aneuploidy or micronuclei. Traip localization during mitosis is sufficient for MB development, suggesting that Traip can repair chromosome bridges during mitosis if necessary. Our results suggest that proper brain size is ensured by the recently described role for TRAIP in unloading stalled replication forks in mitosis, which suppresses DNA bridges and premature neural stem cell loss to promote proper neuron number.
FOXO1 represses sprouty 2 and sprouty 4 expression to promote arterial specification and vascular remodeling in the mouse yolk sac
Authors: Li-Villarreal Nanbing , Wong Rebecca Lee Yean , Garcia Monica D. , Udan Ryan S. , Poché Ross A. , Rasmussen Tara L. , Rhyner Alexander M. , Wythe Joshua D. , Dickinson Mary E. 
Published: March 2022

ABSTRACT
Establishing a functional circulatory system is required for post-implantation development during murine embryogenesis. Previous studies in loss-of-function mouse models showed that FOXO1, a Forkhead family transcription factor, is required for yolk sac (YS) vascular remodeling and survival beyond embryonic day (E) 11. Here, we demonstrate that at E8.25, loss of Foxo1 in Tie2-cre expressing cells resulted in increased sprouty 2 (Spry2) and Spry4 expression, reduced arterial gene expression and reduced Kdr (also known as Vegfr2 and Flk1) transcripts without affecting overall endothelial cell identity, survival or proliferation. Using a Dll4-BAC-nlacZ reporter line, we found that one of the earliest expressed arterial genes, delta like 4, is significantly reduced in Foxo1 mutant YS without being substantially affected in the embryo proper. We show that FOXO1 binds directly to previously identified Spry2 gene regulatory elements (GREs) and newly identified, evolutionarily conserved Spry4 GREs to repress their expression. Furthermore, overexpression of Spry4 in transient transgenic embryos largely recapitulates the reduced expression of arterial genes seen in conditional Foxo1 mutants. Together, these data reveal a novel role for FOXO1 as a key transcriptional repressor regulating both pre-flow arterial specification and subsequent vessel remodeling within the murine YS.
Expression analysis and function of mitochondrial genome-encoded microRNAs
Authors: Kuthethur Raviprasad , Shukla Vaibhav , Mallya Sandeep , Adiga Divya , Kabekkodu Shama Prasada , Ramachandra Lingadakai , Saxena P. U. Prakash , Satyamoorthy Kapaettu , Chakrabarty Sanjiban 
Published: March 2022

ABSTRACT
MicroRNAs (miRNAs) play a significant role in nuclear and mitochondrial anterograde and retrograde signaling. Most of the miRNAs found inside mitochondria are encoded in the nuclear genome, with a few mitochondrial genome-encoded non-coding RNAs having been reported. In this study, we have identified 13 mitochondrial genome-encoded microRNAs (mitomiRs), which were differentially expressed in breast cancer cell lines (MCF-7, MDA-MB-468 and MDA-MB-231), non-malignant breast epithelial cell line (MCF-10A), and normal and breast cancer tissue specimens. We found that mitochondrial DNA (mtDNA) depletion and inhibition of mitochondrial transcription led to reduced expression of mitomiRs in breast cancer cells. MitomiRs physically interacted with Ago2, an RNA-induced silencing complex (RISC) protein, in the cytoplasm and inside mitochondria. MitomiRs regulate the expression of both nuclear and mitochondrial transcripts in breast cancer cells. We showed that mitomiR-5 targets the PPARGC1A gene and regulates mtDNA copy number in breast cancer cells. MitomiRs identified in the present study may be a promising tool for expression and functional analysis in patients with a defective mitochondrial phenotype, including cancer and metabolic syndromes.
This article has an associated First Person interview with the first author of the paper.
Hepatic Arterial Infusion Pump Chemotherapy for Unresectable Intrahepatic Cholangiocarcinoma: A Systematic Review and Meta-Analysis
Authors: Holster Jessica J. , El Hassnaoui Marouan , Franssen Stijn , IJzermans Jan N. M. , de Jonge Jeroen , Mostert Bianca , Polak Wojciech G. , de Wilde Roeland F. , Homs Marjolein Y. V. , Groot Koerkamp Bas 
Published: March 2022

Abstract
Background
Patients with unresectable intrahepatic cholangiocarcinoma (iCCA) have poor survival. This systematic review describes the survival outcomes of hepatic arterial infusion pump (HAIP) chemotherapy with floxuridine for patients with unresectable iCCA.

Patients and Methods
A literature search was conducted using the electronic databases PubMed, Medline (Ovid), Embase, Web of Science, Google Scholar, and Cochrane to find studies that reported data on the survival of patients with unresectable iCCA treated with HAIP chemotherapy using floxuridine. The quality of the studies was assessed using the Newcastle–Ottawa quality assessment Scale (NOS). Overall survival (OS) was the primary outcome measure, and progression-free survival (PFS), response rates, resection rates, and toxicity were defined as secondary outcome measures.

Results
After removing duplicates, 661 publications were assessed, of which nine studies, representing a total of 478 patients, met the inclusion criteria. Three out of nine studies were phase II clinical trials, one study was a prospective dose-escalation study, and the remaining five studies were retrospective cohort studies. After accounting for overlapping cohorts, 154 unique patients were included for pooled analysis. The weighted median OS of patients with unresectable iCCA treated with HAIP chemotherapy with floxuridine was 29.0 months (range 25.0–39 months). The pooled 1-, 2-, 3-, and 5-year OS were 86.4, 55.5, 39.5, and 9.7%, respectively.

Conclusion
HAIP chemotherapy with floxuridine for patients with unresectable iCCA was associated with a 3-year OS of 39.5%, which is favorable compared with systemic chemotherapy for which no 3-year survivors were reported in the Advanced Biliary Cancer (ABC) trials.
Comparison of clinical effectiveness of conventional and self-etch sealant: a split mouth randomized controlled trial
Authors: Gupta Deveshi , Rao Arathi , Shenoy Ramya , Suprabha Baranya Srikrishna 
Published: March 2022

Background: Self-etching has been shown to be beneficial compared to the other resin sealants especially in pediatric practice. The present in-vivo study was designed to clinically evaluate the sealing ability and retention of the self-etching sealant compared to the conventional resin sealant. The aim was to evaluate and compare the retention and marginal integrity of the self-etch and acid etch sealant materials at three, six and twelve-month follow up. Methods: The study was designed as a double blinded, split mouth randomized controlled trial, . In total, 35 children (70 teeth) between 7 and 10 years of age formed part of the study. Group 1 received acid-etch sealant and Group 2 received self-etch sealants. The study participants and the investigator who performed the statistical analysis were blinded to the treatment allocation. All the samples were evaluated at 3, 6, and 12 months. The inter-group and intragroup comparison were carried out using the Chi-Square test and Friedman test with level of significance set at 5% and the P value less than 0.05. Results: Complete retention of sealants was observed in 34.5% of conventional acid etch (group 1) and 22.9% of self-etch samples (group 2) whereas complete loss of sealants were seen in 11.4% of group 1 and 20% of the group 2 samples and intergroup comparison of retention failure was non-significant (p=0.135). In total, 85.7% of the group 1 and 82.9% of the group 2 samples exhibited good marginal integrity with no clinical changes in the enamel around the margins but this was not statistically significant (p=0.5). Conclusions: Sealants with fewer procedural steps and those which provide adequate retention would be ideal for use in children. Thus, self-etch sealants have been found to be effective and efficient as a sealant in the present in-vivo study. Clinical Trials Registry, India registration: CTRI/2019/03/018343 (29/03/2019).
The network structure of depressive symptomatology in Peruvian adults with arterial hypertension
Authors: Ramos-Vera Cristian , Banos-Chaparro Jonatan , Ogundokun Roseline Oluwaseun 
Published: March 2022

Background: Globally, arterial hypertension (AH) has increased by 90% over the last four decades, and has increased by 1.6% in Peru over the previous four years. Scientific evidence indicates the prevalence of depressive symptoms in patients with AH and its importance in the comprehensive evaluation of the adult for adherence to clinical treatment. Previous studies carried out in the Peruvian population with AH mostly report the prevalence and associations, but do not indicate which depressive symptoms are more relevant in patients with AH. This study involved a network analysis of depressive symptomatology in Peruvian patients with AH using network estimation. Network analysis is used in this study for analysis, control, and monitoring purposes. Method: A representative cross-sectional study at the national level, using secondary data from 2019 Demographic and Family Health Survey (ENDES) was performed. The sample used included men and women of age over 17 years diagnosed with AH and was able to respond to Patient Health Questionnaire-9 (PHQ-9). Results: The symptoms of depressive mood (bridging force and centrality) and energy fatigue or loss (bridge centrality) play an essential role in the network structure, as does the feeling of uselessness in terms of closeness and intermediation. Conclusion: The study highlighted the symptoms related to depressive mood and energy fatigue or loss as bridging symptoms, which could trigger a depressive episode in patients diagnosed with AH. The results will contribute to developing personalized treatments aimed at patients with specific depressive symptoms who have also been diagnosed with AH. The study analysis presents statistical coefficients of effect size (≤ 0,1 = small; > 0,1 to < 0,5 = moderate; ≥ 0,5 = large) to determine network connections.
Students’ attitudes and coping strategies relating to online learning during the COVID-19 pandemic: A cross-sectional study
Authors: Rahmat Hawa , Aris Adlene , Mohd Miskam Hazlina , Rajendran Kogilavani , Mashudi Rohaidah 
Published: March 2022

Background: The emergence of the COVID-19 pandemic has forced most classes at the tertiary education level to be held online or in a digital mode. This study investigates Multimedia University (MMU) students’ attitudes and coping strategies in relation to online learning classes during the COVID-19 pandemic. Methods: This is a cross-sectional analysis among students at the MMU campus in Malaysia. Student respondents were chosen using simple random sampling. They answered online surveys developed through Google forms with an appended consent form. Two questions were developed inquiring about students' acceptance of online learning courses to gauge their attitudes. The coping strategies questions were adapted from the Brief-COPE questionnaire with 28 items. There are 14 strategies in the Brief-COPE: self-distraction, active coping, denial, substance use, emotional support, instrumental support, behavioural disengagement, venting, positive reframing, planning, humour, acceptance, religion, and self-blame. We hypothesised that there would be a significant correlation between attitudes and coping strategies among MMU students taking online classes during the COVID-19 pandemic. Results: 8 out of 14 coping strategies were significantly correlated with students’ attitudes towards online learning. The study showed that those students with a positive or accepting attitude towards online learning were more likely to use positive coping strategies. Those students with negative, less accepting attitudes towards online learning seemed to use more negative coping strategies. Conclusion: The study focuses on students studying at MMU. Therefore, the outcome cannot be generalised for all university students in Malaysia. The primary goal of the study was to investigate the attitudes and coping strategies of Multimedia University students when confronted with the unexpected outcomes of the COVID-19 pandemic. The results of the study may assist MMU in understanding student behaviour and developing strategies to assist the students.
Return to work and sport after a humeral shaft fracture
Authors: Oliver William M. , Molyneux Samuel G. , White Timothy O. , Clement Nick D. , Duckworth Andrew D. 
Published: March 2022

Aims The primary aim of this study was to determine the rates of return to work (RTW) and sport (RTS) following a humeral shaft fracture. The secondary aim was to identify factors independently associated with failure to RTW or RTS. Methods From 2008 to 2017, all patients with a humeral diaphyseal fracture were retrospectively identified. Patient demographics and injury characteristics were recorded. Details of pre-injury employment, sporting participation, and levels of return post-injury were obtained via postal questionnaire. The University of California, Los Angeles (UCLA) Activity Scale was used to quantify physical activity among active patients. Regression was used to determine factors independently associated with failure to RTW or RTS. Results The Work Group comprised 177 patients in employment prior to injury (mean age 47 years (17 to 78); 51% female (n = 90)). Mean follow-up was 5.8 years (1.3 to 11). Overall, 85% (n = 151) returned to work at a mean of 14 weeks post-injury (0 to 104), but only 60% (n = 106) returned full-time to their previous employment. Proximal-third fractures (adjusted odds ratio (aOR) 4.0 (95% confidence interval (CI) 1.2 to 14.2); p = 0.029) were independently associated with failure to RTW. The Sport Group comprised 182 patients involved in sport prior to injury (mean age 52 years (18 to 85); 57% female (n = 104)). Mean follow-up was 5.4 years (1.3 to 11). The mean UCLA score reduced from 6.9 (95% CI 6.6 to 7.2) before injury to 6.1 (95% CI 5.8 to 6.4) post-injury (p < 0.001). There were 89% (n = 162) who returned to sport: 8% (n = 14) within three months, 34% (n = 62) within six months, and 70% (n = 127) within one year. Age ≥ 60 years was independently associated with failure to RTS (aOR 3.0 (95% CI 1.1 to 8.2); p = 0.036). No other factors were independently associated with failure to RTW or RTS. Conclusion Most patients successfully return to work and sport following a humeral shaft fracture, albeit at a lower level of physical activity. Patients aged ≥ 60 yrs and those with proximal-third diaphyseal fractures are at increased risk of failing to return to activity. Cite this article: Bone Jt Open 2022;3(3):236–244.