bluuebunny/crossref_metadata_2025_split huggingface dataset:
The surgical management of a patient with chronic renal failure and macrothrombocytopenia related to the MYH9 gene mutation: A case report
Authors: Costa Rafael Fiorese , Bucharles Sérgio Gardano Elias , Kagueiama Douglas Eiji , Kus Cintia Pereira , Andrade Ariane de Almeida , Dirschnabel Acir José , de Araujo Melissa Rodrigues , de Lima Antonio Adilson Soares 
Published: May 2022

AbstractMYH9 disease is a rare genetic disorder in which there is a mutation in the gene for the non‐muscle myosin heavy chain IIA. It initially causes macrothrombocytopenia followed by other clinical manifestations. When the patient reaches adulthood, he can develop chronic kidney failure. Thus, the risk of suffering a hemorrhage, difficulty in repairing and, infections increases in individuals with this disease. In addition, the use of drugs in these patients should be carefully evaluated. An adult patient sought dental care with a complaint associated with a tooth with advanced dental caries. He had severe thrombocytopenia (7000 platelets/mm3), hearing loss, and chronic kidney failure. The diagnosis of MYH9 disease was confirmed through genotyping. After clinical examination, extraction was planned. Local and systemic procedures were used to prevent hemorrhage, especially postoperatively. Although the patient had an infection at the surgical wound site and no episode of postoperative bleeding, the repair process occurred normally. The purpose of this article is to report the surgical management of a patient with MYH9 disease.
When the United States says you do not belong: Suicide‐related thoughts and behaviors among immigrant young adults varying in immigration legal status
Authors: Venta Amanda , Long Tessa , Mercado Alfonso , Garcini Luz M. , Cadenas Germán A. 
Published: May 2022

AbstractBackgroundThe number of immigrants in the United States and the risk of suicide among minoritized individuals have increased. Little research has examined the impact of immigration legal status on suicide‐related thoughts and behaviors (SRTB), despite theoretical and empirical work suggesting that feelings of burdensomeness and failure to belong (prominent among immigrants) are risk factors.MethodsWe examined a diverse sample of foreign‐born young adults (18–25; N = 366). Data collection utilized the Suicide Behaviors Questionnaire Revised and items probing belongingness and immigration status (undocumented/Deferred Action for Childhood Arrivals (DACA), permanent, and citizen).ResultsDACA/undocumented status was associated with increased SRTB compared with permanent and citizen categories. Increased SRTBs were associated with reduced feelings of acceptance in the United States, increased deportation fears, and increased fear of being harassed or hurt. Of these belongingness variables, only the interpersonal—not feeling welcome in the United States—partially mediated the risk relation between DACA/undocumented immigration legal status and SRTBs, whereas physical and legal threat, like deportation, did not.ConclusionsOur results highlight the interpersonal nature of SRTB risk in DACA/undocumented immigrants and the need for targeted culture and context‐appropriate interventions, as well as advocacy and policy to reduce risk in this historically marginalized population.
Randomised controlled trial of glucose‐6‐phosphate dehydrogenase deficient versus non‐deficient red blood cell transfusion in patients with hypoproliferative anaemia
Authors: Krajibthong Suphattharachai , Sahntipurna Vachiraphan , Parnsamut Chalisa , Pitakpolrat Patrawadee , Pattanapongsak Walaporn , Watanaboonyongcharoen Phandee , Rojnuckarin Ponlapat 
Published: May 2022

AbstractBackgroundRecent studies revealed the glucose‐6‐phosphate dehydrogenase (G‐6‐PD) deficiency prevalence of 7.7–10% among Thai blood donors. Transfusion of red blood cells (RBCs) from these subjects potentially causes haemolysis in recipients.MethodsRBC units from the National Blood Centre were sampled to assess G‐6‐PD levels using spectrophotometry. Patients with pure underproduction anaemia requiring blood transfusion were randomised to receive G‐6‐PD‐deficient versus normal ABO‐matched RBCs. Pre‐ and 48‐h post‐transfusion indirect bilirubin, haemoglobin, haematocrit, lactate dehydrogenase (LDH) and haptoglobin were measured.ResultsFrom April 2020 to March 2021, 374 RBC units were tested for G‐6‐PD, and that 25 were found to be G‐6‐PD deficient. Twelve units of G‐6‐PD‐deficient RBCs and 14 units of normal RBCs were given to patients who met the inclusion criteria. The median (interquartile range) increases of indirect bilirubin in G‐6‐PD‐deficient (N = 11) versus normal RBCs (N = 13) were + 0.12 (0.27) versus + 0.01 (1.3) mg/dl, p = 0.030), respectively. The median increases of haemoglobin were 1.00 (0.50) versus + 0.80 (0.95), p = 0.910, respectively. The increases in haematocrit were 2.59 (1.9) versus 2.29 (2.1), p = 0.733, respectively. There were no significant differences in changes of LDH and haptoglobin levels and no transfusion reactions.DiscussionG‐6‐PD‐deficient packed red cells were associated with mildly elevated indirect bilirubin after transfusion, but there was no observed clinical symptoms.
Probable paraneoplastic leukocytosis in a dog with a gastrointestinal stromal tumor
Authors: Gidcumb Emily M. , Bolton Timothy A. , Trusiano Brie , Zimmerman Kurt L. , Oakes Vanessa J. 
Published: May 2022

AbstractA 9‐year‐old female spayed Boston Terrier presented for diagnostic investigation of lethargy, poor appetite, weight loss, and a marked leukocytosis. Significant muscle wasting and a palpable abdominal mass were present on physical examination. Abdominal imaging revealed the mass to be of small intestinal origin; consequently, an intestinal resection and anastomosis were performed without complication. The histopathologic diagnosis was a gastrointestinal stromal tumor, verified by immunohistochemical positivity to CD117 (KIT). Two weeks after discharge, the leukocytosis had resolved. Though the exact molecular mediator of the severe leukocytosis was undetermined, resolution following tumor removal suggests a paraneoplastic cause. To the authors' knowledge, this is the first reported case of probable paraneoplastic leukocytosis secondary to a gastrointestinal stromal tumor in the dog. Gastrointestinal tract imaging should be performed when this uncommon hematologic abnormality is present.
Ureteropyeloscopic removal of a nephrolith from a 19 year old Hanoverian gelding
Authors: Moss Alexandra L. , Acutt Elizabeth V. , Ullal Tarini , Applegate Tanya J. , Hackett Eileen S. 
Published: May 2022

AbstractObjectiveTo describe the ureteropyeloscopic removal of a nephrolith in a horse.AnimalsA 19 year old Hanoverian gelding with history of urolithiasis requiring surgical intervention.Study designCase reportMethodsThe horse presented with signs of abdominal straining and stranguria. A proximal urethral calculus was palpable externally within the perineal urethra. Perineal urethrostomy (PU) at the location of the urethral calculi was performed to remove the urethral obstruction. Left nephrolithiasis was then treated by endoscopic retrieval, inserting the endoscope through the PU. The procedures were performed over 2 consecutive days, with the horse standing and sedated. Medical therapy included antimicrobial and anti‐inflammatory treatment.ResultsThe ureteropyeloscopic removal of a nephrolith from the left renal pelvis was completed. No complications were appreciated following the procedure, and the horse was able to return to athletic activity within 2 weeks. The horse had no further clinical signs referable to urinary dysfunction 7 months later.ConclusionUreteropyeloscopic removal of a nephrolith from the renal pelvis is technically feasible in the equine patient and preserves function of the affected kidney. The availability of a treatment that maintains renal function is a distinct benefit over unilateral nephrectomy, particularly when treating a condition that frequently involves both kidneys.
Multiwalled Carbon Nanotube Reinforced Composites for Strengthening Adhesive Tubular Joints
Authors: Joshi Preeti , Tyagi R. K. 
Published: May 2022

Abstract
Adhesives are widely used for making joints in various structures. A strong and durable joint is required for heavy duty structures. Various reinforcement materials are being used for improving the strength of adhesives. Carbon nanotubes (CNTs) are observed as strong reinforcing material in the development of nanocomposites. In this work multiwalled carbon nanotube (MWCNT), reinforced epoxy adhesives are used for strengthening tubular joints in pipe sections. Continuum modeling approach using finite element method is applied for the design and analysis of tubular joint. Stresses at the joint section are analyzed under tensile and torsion loading conditions. Effect of geometrical parameters such as adhesive thickness, overlap length and pipe material in the strength of the joint is determined. The results obtained can be used to optimize the joint. The simulation technique used in this work is found to be useful for the composite pipe designers for designing joints for pipe applications. A comparison of von mises stresses for MWCNT-reinforced epoxy adhesive and epoxy adhesive indicates that MWCNT filled epoxy joints provide higher bonding strength than the epoxy joints. The present model is validated with Lubkin and Reissner’s model. The plot of normalized stresses for both models reveals that the finite element results are in good agreement with the theoretical results.
Comparison of activPAL and Actiwatch for Estimations of Time in Bed in Free-Living Adults
Authors: Hidde Mary C. , Lyden Kate , Broussard Josiane L. , Henry Kim L. , Sharp Julia L. , Thomas Elizabeth A. , Rynders Corey A. , Leach Heather J. 
Published: May 2022

Introduction: Patterns of physical activity (PA) and time in bed (TIB) across the 24-hr cycle have important implications for many health outcomes; therefore, wearable accelerometers are often implemented in behavioral research to measure free-living PA and TIB. Two accelerometers, the activPAL and Actiwatch, are common accelerometers for measuring PA (activPAL) and TIB (Actiwatch), respectively. Both accelerometers have the capacity to measure TIB, but the degree to which these accelerometers agree is not clear. Therefore, this study compared estimates of TIB between activPAL and the Actiwatch accelerometers. Methods: Participants (mean ± SDage = 39.8 ± 7.6 years) with overweight or obesity (N = 83) wore an activPAL and Actiwatch continuously for 7 days, 24 hr per day. TIB was assessed using manufacturer-specific algorithms. Repeated-measures mixed-effect models and Bland–Altman plots were used to compare the activPAL and Actiwatch TIB estimates. Results: Statistical differences between TIB assessed by activPAL versus Actiwatch (p < .001) were observed. There was not a significant interaction between accelerometer and day of wear (p = .87). The difference in TIB between accelerometers ranged from −72.9 ± 15.7 min (Day 7) to −98.6 ± 14.5 min (Day 3), with the Actiwatch consistently estimating longer TIB compared with the activPAL. Conclusion: Data generated by the activPAL and Actiwatch accelerometers resulted in divergent estimates of TIB. Future studies should continue to explore the validity of activity monitoring accelerometers for estimating TIB.
Energy Costs of Household and Eldercare Activities in Young to Middle-Aged Chinese Adults
Authors: Li Yiyan , Liu Jiajia , Quan Minghui , Zhuang Jie , Cao Zhen-Bo , Zhu Zheng , Li Yongming , Herrmann Stephen D. , Ainsworth Barbara E. 
Published: May 2022

Background: The 2011 Compendium of Physical Activities provides metabolic equivalent (MET) values for household and eldercare activities (physical activities [PAs]). METs are from published studies, estimated if values are not published, or combined with other PAs with different METs in a single entry. Some PAs are missing from the Compendium. This study measures the energy costs for 15 household and eldercare PAs with estimated METs, PAs in combined entries, and new PAs. Methods: Participants were 30 adults (14 males and 16 females), ages 22–58 years (33.7 [11.2] y). PAs were measured in a laboratory for 8 minutes with a 4-minute rest between PAs. A portable indirect calorimeter measured oxygen uptake (in milliliters per kilogram per minute). Standard METs were computed as activity VO2/3.5 mL·kg−1·min−1. Results: Cooking, meal tasks, laundry, light cleaning, and watering plants ranged from 1.8 to 2.3 METs. Sweeping, walking, and carrying groceries and boxes on the ground and stairs ranged from 3.0 to 5.5 METs. Eldercare ranged from 1.8 to 3.0 METs. Measured METs differed from estimated values by ±0.3 to 2.2 METs. Most measured METs were lower than estimated METs. Conclusion: Updating estimated METs with measured values and separating PAs from combined entries increases the accuracy of household and eldercare PAs presented in the Compendium.
Development of Low-Molecular-Weight Allosteric Agonist of Thyroid-Stimulating Hormone Receptor with Thyroidogenic Activity
Authors: Bakhtyukov A. A. , Derkach K. V. , Fokina E. A. , Sorokoumov V. N. , Zakharova I. O. , Bayunova L. V. , Shpakov A. O. 
Published: May 2022

Abstract
To normalize the thyroid status in hypothyroidism caused by resistance to thyroid-stimulating hormone (TSH), low-molecular-weight allosteric agonists of TSH receptor can be used. A new compound ethyl-2-(4-(4-(5-amino-6-(tert-butylcarbamoyl)-2-(methylthio)thieno[2,3-d]-pyrimidine-4-yl)phenyl)-1H-1,2,3-triazol-1-yl) acetate (TPY3m), which stimulated the production of thyroxine when administered to rats (25 mg/kg, i.p.) and also increased the expression of thyroidogenic genes in the cultured FRTL-5 thyrocytes (30 μM) and the rat thyroid gland. The in vitro and in vivo treatment with TPY3m did not lead to a decrease in the expression of the TSH receptor gene in thyrocytes, restoring it under the conditions of receptor hyperactivation by the hormone. This determines the retaining and, in some cases, potentiation of the thyroidogenic effects of TSH (FRTL-5) or thyroliberin (rats) when they are coadministered with TPY3m. TPY3m is a prototype drug for correcting thyroid system functions in subclinical hypothyroidism.
OPTIMUM study protocol: an adaptive randomised controlled trial of a mixed whole-cell/acellular pertussis vaccine schedule
Authors: Perez Chacon Gladymar , Estcourt Marie J , Totterdell James , Campbell Dianne E , Perrett Kirsten P , Marsh Julie A , Richmond Peter C , Wood Nicholas , Gold Michael S , Holt Patrick G , Waddington Claire S , Snelling Thomas L 
Published: May 2022

IntroductionCombination vaccines containing whole-cell pertussis antigens were phased out from the Australian national immunisation programme between 1997 and 1999 and replaced by the less reactogenic acellular pertussis (aP) antigens. In a large case–control study of Australian children born during the transition period, those with allergist diagnosed IgE-mediated food allergy were less likely to have received whole-cell vaccine in early infancy than matched population controls (OR: 0.77 (95% CI, 0.62 to 0.95)). We hypothesise that a single dose of whole-cell vaccine in early infancy is protective against IgE-mediated food allergy.Methods and analysisThis adaptive double-blind randomised controlled trial is investigating whether a mixed whole-cell/aP vaccine schedule prevents allergic disease in the first year of life. The primary outcome is IgE-mediated food allergy by 12 months of age. Secondary outcomes include new onset of atopic dermatitis by 6 or 12 months of age; sensitisation to at least one allergen by 12 months of age; seroconversion in anti-pertussis toxin IgG titres after vaccination with aP booster at 18 months of age; and solicited systemic and local adverse events following immunisation with pertussis-containing vaccines. Analyses will be performed using a Bayesian group sequential design.Ethics and disseminationThis study has been approved by the Child and Adolescent Health Service Human Research Ethics Committee, Perth, Western Australia (RGS 00019). The investigators will ensure that this trial is conducted in accordance with the principles of the Declaration of Helsinki and with the International Conference on Harmonisation Guidelines for Good Clinical Practice. Individual consent will be requested. Parents will be reimbursed reasonable travel and parking costs to attend the study visits. The dissemination of these research findings will follow the National Health and Medical Research Council of Australia Open Access Policy.Trial registration numberACTRN12617000065392p.
Autoantibodies against specific post-translationally modified proteins are present in patients with lupus and associate with major neuropsychiatric manifestations
Authors: Monahan Rory C , van den Beukel Michelle D , Borggreven Nicole V , Fronczek Rolf , Huizinga Tom W J , Kloppenburg Margreet , Steup-Beekman Gerda M , Trouw Leendert A 
Published: May 2022

BackgroundAlthough autoantibodies are an important hallmark of systemic lupus erythematosus (SLE), most are not specific for SLE or any of its clinical manifestations. Autoantibodies against post-translationally modified (PTM) proteins have been studied extensively in rheumatoid arthritis and associate with disease progression. While PTMs have also been detected in patients with SLE, studies on anti-PTM antibodies remain scarce. We studied the presence of anti-PTM antibodies in SLE and neuropsychiatric SLE (NPSLE), a manifestation that lacks serological markers.MethodsIgG antibody responses against six PTMs (malondialdehyde–acetaldehyde adducts (MAA), advanced glycation end-products (AGE), carbamylation (CarP), citrullination, acetylation and nitration) were tested using ELISA in sera of 349 patients with SLE (mean age 44±13 years; 87% female) and compared with 108 healthy controls. Levels and positivity were correlated with clinical features and SLE manifestations.ResultsAnti-MAA, anti-AGE and anti-CarP antibodies were more prevalent in SLE compared with controls (MAA: 29% vs 3%, AGE: 18% vs 4%, CarP: 14% vs 5%, all p≤0.0001). Anti-MAA and anti-AGE antibodies correlated with clinical manifestations and serological inflammatory markers. Patients with major NPSLE showed higher positivity of anti-MAA (39% vs 24%, p=0.01) and anti-CarP antibodies (20% vs 11%, p=0.04) than patients without major NPSLE. In addition, anti-PTM antibody levels correlated with brain volumes, an objective measure of nervous system involvement.ConclusionsIn our NPSLE cohort, a subset of patients with SLE have anti-PTM antibodies against MAA, AGE and CarP modified proteins. Interestingly, anti-MAA and anti-CarP were more prevalent in NPSLE, a manifestation for which no biomarkers exist.
Indecomposability of top local cohomology modules and connectedness of the prime divisors graphs
Authors: Doustimehr Mohammad Reza 
Published: May 2022

Let [Formula: see text] be an ideal of a Noetherian local ring [Formula: see text] with [Formula: see text] and [Formula: see text] be a positive integer. In this paper, it is shown that the top local cohomology module [Formula: see text] (equivalently, its Matlis dual [Formula: see text]) can be written as a direct sum of [Formula: see text] indecomposable summands if and only if the endomorphism ring [Formula: see text] can be written as a direct product of [Formula: see text] local endomorphism rings if and only if the set of minimal primes [Formula: see text] of [Formula: see text] with [Formula: see text] can be written as disjoint union of [Formula: see text] non-empty subsets [Formula: see text] such that for all distinct [Formula: see text] and all [Formula: see text] and all [Formula: see text], we have [Formula: see text]. This generalizes Theorem 3.6 of Hochster and Huneke [Contemp. Math. 159 (1994) 197–208].
ASYMMETRIC DEPENDENCE BETWEEN EXCHANGE RATE AND COMMODITY PRICES IN GHANA
Authors: ARCHER CHRISTINA , JUNIOR PETERSON OWUSU , ADAM ANOKYE M. , ASAFO-ADJEI EMMANUEL , BAFFOE STEPHEN 
Published: May 2022

An increase in globalization and financial integration has induced countries to depend on each other to survive. This has facilitated trade and investments among economies across the globe. It is expected that countries’ international economic activities would contribute to the rate of exchange between the countries. However, uncertainties may alter the dynamics of exchange rate movements, thereby minimizing the contribution of its economic activities at various market conditions. In this regard, we examine the influence of variations in prices of commodities on nominal exchange rate in Ghana. Hence, we employ quantile regression with monthly data spanning from September 2007 to December 2020 for the variables — nominal exchange rate, cocoa, gold and Brent crude oil prices. We find a significant connection among the variables for most quantiles. Also, the study reveals that an upsurge in the price of crude oil corresponds to an appreciation of the Ghana Cedi during turbulent conditions. Conversely, cocoa price tends to appreciate the Ghana Cedi for both normal and extreme market conditions. We recommend that for the country to enjoy favorable exchange rate at all market conditions, there is a need for the producers of these exported commodities to be incentivized by the government in the form of subsidies, new technological equipment and education in order for the producers to increase their efficiency and add value to these commodities while effective inflation targeting policies are deployed. Implications for the study are further provided.
A Mini-Review on the Insight into the Effect of Natural and Synthetic α,β-Unsaturated Carbonyl-Containing Compounds on PI3K/AKT/mTOR Signaling Pathways to Treat Breast Cancer
Authors: Voon Kelvin Wong Khai , Gazali Ahmad Mahfuz , Zamri Normaiza , Rullah Kamal , Aluwi Mohd Fadhlizil Fasihi Mohd 
Published: May 2022

Breast cancer, which has been one of the most frequently diagnosed cancers worldwide for decades, continues to defy treatment. While researching a remedy to this problem, it was discovered that mTOR has a strong association with breast cancer. Uncontrolled activation of mTOR is shown in a variety of different cancer, making it a critical target for cancer treatment. Inhibition of the mTOR protein kinase can cause autophagic cell death. It is known that covalent inhibitors have become a prominent issue in drug discovery, with covalent inhibitors focusing on [Formula: see text]-unsaturated carbonyl molecules. Structural modifications to [Formula: see text]-unsaturated carbonyl may be one of the finest avenues for developing the best breast cancer medication. This review article discusses recent research on natural and synthetic [Formula: see text]-unsaturated carbonyls and their anti-cancer properties targeting on mTOR, with SAR to showcase the efficacy of synthetic natural products compared to parental compounds using both biological assays and in silico studies.
From Centuries to Hours: The Journey of Research into Practice
Authors: Bragge Peter 
Published: May 2022

COVID-19 has made the research-policy nexus visible as never before. Public health officials, doctors and scientists are standing alongside political and other leaders all around the world to promote research-informed health behaviors to ‘flatten the curve’ of this global pandemic. Proper hand hygiene, physical distancing and use of masks are now either recommended or mandated everyday public health behaviors across the world. Obviously, application of research to public problem solving is not new. However, the pace of the journey from research to policy and practice has shortened at a similar exponential rate as the spread of the virus.
This paper provides a historical overview of research-informed policy and practice. In doing so, it aims to build an understanding of how research is able to address COVID-related policy questions in almost real-time; how the demand-side consequences of this global pandemic have advanced research-informed policy and practice; and how policymakers can harness research to solve public policy problems in the future.