bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tailored gamification in education: A literature review and future agenda
Authors: Oliveira Wilk , Hamari Juho , Shi Lei , Toda Armando M. , Rodrigues Luiz , Palomino Paula T. , Isotani Seiji 
Published: June 2022

AbstractGamification has been widely used to design better educational systems aiming to increase students’ concentration, motivation, engagement, flow experience, and others positive experiences. With advances in research on gamification in education, over the past few years, many studies have highlighted the need to tailor the gamification design properties to match individual students’ needs, characteristics and preferences. Thus, different studies have been conducted to personalize the gamification in education. However, the results are still contradictory and need to be better understood to advance this field. To provide a complete understanding of this research domain, we conducted a systematic literature review to summarize the results and discussions on studies that cover the field of tailored gamified education. Following a systematic process, we analysed 2108 studies and identified 19 studies to answer our research questions. The results indicate that most of the studies only consider students’ gamer types to tailor the systems, and most of the experiments do not provide sufficient statistical evidence, especially regarding learning performance using tailored gamified systems. Based on the results, we also provided an agenda with different challenges, opportunities, and research directions to improve the literature on tailored gamification in education. Our study contributes to the field of gamification design in education.
Split N application and DMP based nitrification inhibitors mitigate N2O losses in a soil cropped with winter wheat
Authors: Guzman-Bustamante Ivan , Schulz Rudolf , Müller Torsten , Ruser Reiner 
Published: June 2022

AbstractNitrogen (N) fertilization to crops might lead to formation and release of reactive N—e.g. nitrate, ammonium, ammonia, nitrous oxide (N2O) —, contributing to eutrophication, atmospheric pollution, and climate change. Use of nitrification inhibitors and splitting of N fertilizer may reduce the N2O emission from arable soils cropped with winter wheat. We tested different N fertilizers treated with 3,4-dimethylpyrazol phosphate (DMPP) and 3,4-dimethylpyrazol succinic acid (DMPSA) by applying 180 kg N ha−1 in different N splitting strategies in a full annual field experiment on a loamy soil in Southwest Germany. A threefold split fertilization led to an emission of 2.3 kg N2O–N ha−1 a−1 (corresponding to a reduction of 19%) compared to a single application of ammonium sulphate nitrate (ASN) (p = 0.07). A single application rate of ASN with DMPP resulted in an emission of 1.9 kg N2O–N ha−1 a−1 and reduced N2O emissions from an ASN treatment without NI by 33%. Calcium ammonium nitrate (CAN) with DMPSA reduced N2O emissions during the vegetation period by 38% compared to CAN without a nitrification inhibitor, but this was offset by high emissions after harvest, which was driven by soil tillage with an annual reduction of 26% (CAN: 2.9 kg N2O–N ha−1 a−1; CAN + DMPSA: 2.1 kg N2O–N ha−1 a−1; p = 0.11). Among our tested treatments, a twofold split application of ASN with DMPP efficiently reduced N2O emissions and maintained grain yield when compared to the traditional system with threefold application without nitrification inhibitor. Despite resulting in lower protein contents in the twofold split application, this treatment should be further investigated as a potential compromise between wheat yield and quality optimization and climate protection.
Weight dependence in BCM leads to adjustable synaptic competition
Authors: Albesa-González Albert , Froc Maxime , Williamson Oliver , Rossum Mark C. W. van 
Published: June 2022

AbstractModels of synaptic plasticity have been used to better understand neural development as well as learning and memory. One prominent classic model is the Bienenstock-Cooper-Munro (BCM) model that has been particularly successful in explaining plasticity of the visual cortex. Here, in an effort to include more biophysical detail in the BCM model, we incorporate 1) feedforward inhibition, and 2) the experimental observation that large synapses are relatively harder to potentiate than weak ones, while synaptic depression is proportional to the synaptic strength. These modifications change the outcome of unsupervised plasticity under the BCM model. The amount of feed-forward inhibition adds a parameter to BCM that turns out to determine the strength of competition. In the limit of strong inhibition the learning outcome is identical to standard BCM and the neuron becomes selective to one stimulus only (winner-take-all). For smaller values of inhibition, competition is weaker and the receptive fields are less selective. However, both BCM variants can yield realistic receptive fields.
Defining Explanation and Explanatory Depth in XAI
Authors: Buijsman Stefan 
Published: June 2022

AbstractExplainable artificial intelligence (XAI) aims to help people understand black box algorithms, particularly of their outputs. But what are these explanations and when is one explanation better than another? The manipulationist definition of explanation from the philosophy of science offers good answers to these questions, holding that an explanation consists of a generalization that shows what happens in counterfactual cases. Furthermore, when it comes to explanatory depth this account holds that a generalization that has more abstract variables, is broader in scope and/or more accurate is better. By applying these definitions and contrasting them with alternative definitions in the XAI literature I hope to help clarify what a good explanation is for AI.
Tracking the legacy of early industrial activity in sediments of Lake Zurich, Switzerland: using a novel multi-proxy approach to find the source of extensive metal contamination
Authors: Roethlin Remo Luis , Gilli Adrian , Wehrli Bernhard , Gilli Robin Sue , Wiederhold Jan Georg , Dubois Nathalie 
Published: June 2022

AbstractHistorical industrial activities at the Horn Richterwil, on the shore of Lake Zurich (Switzerland), caused widespread metal contamination on land and in the adjacent lake sediments. This study provides an estimation of the age and source of the contamination by using XRF core scanning, ICP-OES, and Hg-AFS for quantitative measurements of trace metals and MC-ICP-MS for the stable isotope analysis of mercury. Radiometric dating ($$^{137}$$

137

Cs, $$^{210}$$

210

Pb, and Pu dating) of two proximal cores and varve chronology in a distal core suggest two different contaminations, one stemming from around 1960 (Zn, Cd) and an earlier one from 1880 (Cr, Cu, Hg, Pb, Sn). The XRF data suggest two different contamination pathways: one by landfill of contaminated soil and another one by industrial wastewater effluents. Maximum concentrations found within all samples are in the range of per mil (dry weight) for Cr, Cu, Hg, Pb, Sn, and Zn and lie within the top 10 cm of the sediment cores. The analysis of the mercury isotopic composition ($$\delta ^{202}$$

δ
202

Hg and $$\Delta ^{199}$$

Δ
199

Hg) shows a significantly different signature for one of the cores, indicating a second mercury source. We could not identify the exact source or process leading to the isotopic fractionation of mercury, but the isotopic data confirm two different sources.
Multi-endpoint effects of derelict tubular mussel plastic nets on Tigriopus fulvus
Authors: Parlapiano Isabella , Biandolino Francesca , Grattagliano Asia , Ruscito Andrea , Lofrano Giusy , Libralato Giovanni , Trifuoggi Marco , Albarano Luisa , Prato Ermelinda 
Published: June 2022

Abstract
Microplastic debris from direct and indirect human activities is considered a major threat to the marine biodiversity mainly due to its abundance, durability, persistence, and ability to accumulate contaminants from the environment. Derelict tubular plastic nets of various colours (blue (BN), yellow (YN), green (GN), pink (PN), and white (WN) net), used to distinguish mussel farming owners, were collected by scuba-dive from the Mar Piccolo of Taranto (Ionian Sea). All nets were made of polypropylene. Investigations looked for potential acute (mortality) and sub-chronic (mortality, larval development and moult release number, and adult percentage after 5–9 days) effects on Tigriopus fulvus nauplii considering both whole plastics (microplastic (MP), 50 mg/L) and leachates (12.5–100%). Acute test determined a median lethal concentration (LC50) only for BN for both MPs (107 mg/L) and leachates (50.1%). The prolonged exposure (5 days) to microplastics did not affect the T. fulvus survival. After 9 days, YN and BN decreased of approximately 100% larval development.
Graphical abstract
Antitumour effects of apatinib in progressive, metastatic differentiated thyroid cancer (DTC)
Authors: Shi Liang , You Qinqin , Wang Jun , Wang Hanjin , Li Shaohua , Tian Rui , Yao Xiaocheng , Wu Wenyu , Zhang Lele , Wang Feng , Lin Yansong , Li Shuren 
Published: June 2022

Abstract
Purpose
Management of progressive, metastatic radioactive iodine refractory differentiated thyroid cancer (RAIR-DTC) has been a great challenge due to its poor prognosis and limited treatment options. Recently, apatinib, an orally anti-angiogenic tyrosine kinase inhibitor (TKI) is reported to be useful for treatment of progressive RAIR-DIC. The aim of this study was to evaluate the antitumour effect of apatinib and the combination therapy with radioactive iodine (RAI) in patients with progressive metastatic DTC.

Methods
Five patients (all female, mean age 62 ± 8 years, ranged from 51 to 69 years) with distant metastatic DTC (dmDTC) after total thyroidectomy (TTE) and neck lymph node dissection were treated with apatinib at a dose 500 mg per day after 18F-Fluorodeoxyglucose (18F-FDG) PET/CT. The effects of apatinib on DTC were evaluated at 4 ± 1 months after treatment with apatinib. RAI therapy was then initiated. The response to apatinib and the combination therapy with RAI treatment was evaluated by Response Evaluation Criteria in Solid Tumours (RECIST, version 1.1) and metabolic activity using serum thyroglobulin (Tg) and 18F-FDG PET/CT.

Results
Positive 18F-FDG PET/CT results were found in all patients before apatinib therapy. The immunohistochemical analysis of primary tumour tissues showed high expression of vascular endothelial growth factor receptor-2 (VEGFR-2). Four patients with follicular thyroid carcinoma (FTC) showed partial response (PR) with significant decrease in tumour size and maximum standardized uptake value (SUVmax) after 4 ± 1 month’s treatment with apatinib. Further significant reduction of tumour size and SUVmax were observed in three patients after combination therapy with apatinib and RAI. Only one patient with both FTC and papillary thyroid cancer (PTC) demonstrated progressive disease (PD) after treatment with apatinib alone, however, a decrease in tumour size and SUVmax as well as serum Tg levels was achieved after the combination with RAI therapy and apatinib.

Conclusions
Apatinib had significant antitumour effects on progressive distant metastatic DTC. Moreover, beneficial synergistic and complementary effects were shown when apatinib combined with RAI therapy.

Clinical Trial Registration
NCT 04180007, Registered November 26, 2019.
Simplified vortex methods to model wake vortex roll-up in real-time simulations for fuel-saving formation flight
Authors: Spark Henrik , Luckner Robert 
Published: June 2022

AbstractOne possibility for reducing fuel consumption is to fly in the upwind field of the wake vortex generated by an aircraft that is flying ahead. Migratory birds use this principle. Manually flying an aircraft at the point of optimal fuel reduction is not suited for routine flight operations as the pilot workload is excessively high. Hence, an autopilot function has to carry out this task. For designing the autopilot, a flight mechanical simulation with a wake vortex velocity model is required that has the ability to calculate the vortex-induced velocity fields. This paper contributes to the choice of a real-time simulation method for modelling vortex-induced velocities that the wake vortex of a leading aircraft generates and that the trailing aircraft shall use during fuel-saving formation flight.Two different wake vortex velocity models are introduced and compared during steady, horizontal flight. One model is based on the Lifting Line Method (LLM) and the other on the unsteady Vortex Lattice Method (VLM). Both models are able to calculate the wake vortex roll-up phase for arbitrary lift distributions, whereas the commonly used Single Horseshoe Vortex Model (SHVM) ignores the near-field roll up. The differences in the induced upwind distribution and vortex filament position are analysed for coarse spatial and temporal discretisation that the real-time constraint requires. Despite the more stringent simplifications of LLM, both methods yield similar filament positions and similar velocity fields for the same discretisation of the lifting surfaces. Finally, the influence of the discretisation parameters is discussed and parameter values are recommended for using VLM and LLM in real-time flight simulations.
Case report. Successful conservative treatment in a symptomatic postmenopausal woman with a urethral prolapse
Authors: Vreeburg Manon T. A. , Wiltink Judith 
Published: June 2022

AbstractA 75 years old female presented at the department of Urology with vaginal bleeding, urinary tract symptoms and a protruding mass. Pelvic examination showed a urethral prolapse. There was no recurrence of the urethral prolapse after a combination of manual reduction, a pessary, a transurethral catheter for 10 days and estrogen cream for three months. Literature describes some cases concerning conservative treatment in women with symptomatic urethral prolapse. The best reasonable treatment option for this group of women would be surgical excision. This case report shows a symptomatic urethral prolapse in a post-menopausal woman with good results after non-surgical treatment, a combination of manual reduction, a transurethral catheter and a pessary, with a follow up of eight months.
Azobenzene-Based Solar Thermal Fuels: A Review
Authors: Zhang Bo , Feng Yiyu , Feng Wei 
Published: June 2022

AbstractThe energy storage mechanism of azobenzene is based on the transformation of molecular cis and trans isomerization, while NBD/QC, DHA/VHF, and fulvalene dimetal complexes realize the energy storage function by changing the molecular structure. Acting as “molecular batteries,” they can exhibit excellent charging and discharging behavior by converting between trans and cis isomers or changing molecular structure upon absorption of ultraviolet light. Key properties determining the performance of STFs are stored energy, energy density, half-life, and solar energy conversion efficiency. This review is aiming to provide a comprehensive and authoritative overview on the recent advancements of azobenzene molecular photoswitch system in STFs fields, including derivatives and carbon nano-templates, which is emphasized for its attractive performance. Although the energy storage performance of Azo-STFs has already reached the level of commercial lithium batteries, the cycling capability and controllable release of energy still need to be further explored. For this, some potential solutions to the cycle performance are proposed, and the methods of azobenzene controllable energy release are summarized. Moreover, energy stored by STFs can be released in the form of mechanical energy, which in turn can also promote the release of thermal energy from STFs, implying that there could be a relationship between mechanical and thermal energy in Azo-STFs, providing a potential direction for further research on Azo-STFs.
A qualitative assessment of nonclinical drivers of pediatric outpatient antibiotic prescribing: The importance of continuity
Authors: Spencer Hillary J. J. , Katz Sophie , Staub Milner , Audet Carolyn M. , Banerjee Ritu 
Published: June 2022

Abstract

Background and objectives:
Antibiotic overuse is common in outpatient pediatrics and varies across clinical setting and clinician type. We sought to identify social, behavioral, and environmental drivers of outpatient antibiotic prescribing for pediatric patients.

Methods:
We conducted semistructured interviews with physicians and advanced practice providers (APPs) across diverse outpatient settings including pediatric primary, urgent, and retail care. We used the grounded theory constant comparative method and a thematic approach to analysis. We developed a conceptual model, building on domains of continuity to map common themes and their relationships within the healthcare system.

Results:
We interviewed 55 physicians and APPs. Clinicians across all settings prioritized provision of guideline-concordant care but implemented these guidelines with varying degrees of success. The provision of guideline-concordant care was influenced by the patient–clinician relationship and patient or parent expectations (relational continuity); the clinician’s access to patient clinical history (informational continuity); and the consistency of care delivered (management continuity). No difference in described themes was determined by setting or clinician type; however, clinicians in primary care described having more reliable relational and informational continuity.

Conclusions:
Clinicians described the absence of long-term relationships (relational continuity) and lack of availability of prior clinical history (informational continuity) as factors that may influence outpatient antibiotic prescribing. Guideline-concordant outpatient antibiotic prescribing was facilitated by consistent practice across settings (management continuity) and the presence of relational and informational continuity, which are common only in primary care. Management continuity may be more modifiable than informational and relational continuity and thus a focus for outpatient stewardship programs.
Appropriateness of prescribed oral antibiotic duration at the time of hospital discharge
Authors: Sedlock Carly E. , Cavaretta Marissa J. , Haines Alexander J. , Nguyen Kevin B. , Agarwal Neelesh , Gallagher Jason C. 
Published: June 2022

Abstract
Antibiotic stewardship initiatives usually occur in the inpatient setting and should be optimized during transitions of care. In this study, we assessed the appropriateness of oral antibiotic treatment duration at the time of discharge from our institution based on national guidelines and clinical parameters for common infections.
Immigration, Policy Exclusion, and State-Level Inequality in TANF Usage
Authors: Xu Ping , Zhu Ling 
Published: June 2022

AbstractThe relationship between immigration and welfare provision is at the heart of welfare politics research. While prior studies have examined how immigration affects welfare generosity, less is known about the consequences of exclusive welfare policies and immigration on social inequality. In this paper, by using TANF as the policy context, we offer a systematic examination of how immigration combined with state immigrant welfare policies affect inequality in welfare usage between citizens and immigrants. Using data across the fifty American states from 2001 to 2016, we find evidence that exclusive state immigrant TANF policies are a key source of decreased immigrant TANF caseload rate and enlarged citizen-immigrant TANF caseload gap. Moreover, states’ immigrant population density moderates the effect of state immigrant welfare eligibility policies on immigrant TANF caseload rate and citizen-immigrant TANF caseload gap. Our robustness checks by using alternative measures of the dependent variable and key independent variable verify these findings.
The origin of Patagonia: insights from Permian to Middle Triassic magmatism of the North Patagonian Massif
Authors: Falco Juan Ignacio , Hauser Natalia , Scivetti Nicolás , Reimold Wolf Uwe , Folguera Andres 
Published: June 2022

AbstractWe conducted a U–Pb–Hf isotope study on zircon crystals from ignimbrites of the Changhsingian to Olenekian (253–248 Ma) Los Menucos Basin in the North Patagonian Massif (NPM), Argentina, in order to evaluate the age and petrogenesis of the magmas. Additionally, a compilation of whole-rock geochemistry and U–Pb–Hf in zircon isotope data for the Permian to Middle Triassic rocks of the NPM, for comparison with our data, was made to assess whether Patagonia would have been an exotic terrane accreted to SW Gondwana during the late Palaeozoic. We interpret the available U–Pb–Hf data to suggest that northern Patagonia experienced eastward arc expansion from the early Permian, about 273 Ma ago. This ∼820 km arc expansion event involved crustal shortening and magmatism with high-silica adakitic affinity, resulting in Hf-isotopic pull-down. At 253 Ma, slab steepening became associated with the coeval emplacement of ignimbrites of the Los Menucos Basin, which involved post-orogenic to intraplate magmatism. During the Middle Triassic, a slab break-off triggered uplift and basaltic underplating, promoting the emplacement of dike swarms with C-type adakitic signature at 246–244 Ma. The Hf isotope data for SW Gondwana for the same period indicate distinct trends that are explained here by differential slab roll-back since the Guadalupian, in a slab-tearing setting. Therefore, Permian to Middle Triassic magmatism is interpreted as having been associated with an eastward-directed proto-Pacific subduction system, which ultimately supports an autochthonous origin for Patagonia.
Origin of magmatic and tectonic fabrics in the Remal granite-gneiss, Singhbhum Craton, India
Authors: Dobe Ritabrata , Vukmanovic Zoja , Bose Narayan , Panigrahi Mruganka Kumar , Gupta Saibal 
Published: June 2022

AbstractIn the Singhbhum Craton of the Indian shield, the Remal granite-gneiss preserves felsic magmatic fabrics onto which a low-temperature segregation layering has been superposed. Planar, sub-horizontal to gently dipping layers (Sign1) comprise K-feldspar megacrysts, plagioclase and quartz, with the base of each layer defined by segregations of biotite. Sign2 consists of trough cross-bedded layers composed of K-feldspar phenocrysts, plagioclase and quartz with biotite schlieren defining the base of each layer. Microstructural features such as concentrically arranged mineral inclusions in K-feldspar phenocrysts and graphic intergrowth textures testify to the magmatic origin of these fabrics, with insignificant subsequent metamorphic reconstitution. The tectonic fabric S1 has developed sub-parallel to localized greenschist-facies mylonite bands, and is defined by weakly aligned flakes of biotite. Crystallographic preferred orientations away from the mylonitized domains show a strong alignment of K-feldspar, quartz and biotite parallel to the magmatic fabric due to efficient segregation during magmatic flow. Quartz crystallographic preferred orientations within the mylonitized domains show a strong preferred orientation and dextral asymmetry. Temperature constraints from synkinematic chlorites along with estimates of deformation temperature from quartz crystallographic preferred orientations indicate that mylonitization occurred at the lower limits of quartz crystal plasticity. The results of combined thermodynamic and multiphysics modelling studies show that felsic magmas can undergo significant convective motion for a wide range of crystallinities and water contents before solidification. Additionally, segregation layering resembling a gneissosity can develop at low temperatures owing to localized mylonitization and concomitant dissolution–precipitation of biotite.