bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidants in the Prevention of Cisplatin-Induced Hearing Loss: A Systematic Review and Meta-Analysis
Authors: King Rich Ericson C. , Ong Kimberly Mae C. 
Published: June 2022

Abstract
Background Cisplatin is a commonly used chemotherapeutic drug that is associated with irreversible hearing loss. A number of antioxidants have been investigated for prevention, but data have so far been inconclusive.
Objective The objective of this study was to assess the efficacy of various antioxidant therapies in preventing hearing loss among adult patients treated with cisplatin.
Methodology We searched for controlled clinical trials evaluating various antioxidants as prevention against cisplatin-induced hearing loss in adults. The primary outcome is the proportion of patients with hearing loss. Secondary outcomes include audiometric threshold shifts, tinnitus, tumor response, adverse events, and quality of life.
Results Thirteen randomized trials comprising of nine antioxidant therapies were included. Only coenzyme Q with multivitamins demonstrated significant benefit in preventing cisplatin-induced hearing loss (relative risk: 0.15, 95% confidence interval: 0.04–0.58) in a small study, while data for the rest of the agents were inconclusive. Audiometric threshold shifts were significantly lower in the intervention arm for aspirin, vitamin E, and transtympanic dexamethasone. The available data on tumor response was inconclusive, with no definite evidence of diminished tumor response noted. Adverse events noted include mild ear pain particularly for transtympanic therapies. There was no data available on quality of life.
Conclusion The current available evidence is so far insufficient to establish any benefit for antioxidant therapies for the prevention of cisplatin-induced hearing loss. More high-quality studies are needed to fill in the identified gaps in knowledge.
Pregnancy in Patients with Non-cirrhotic Portal Hypertension: A Literature Review
Authors: Giri Suprabhat , Sahoo Shradhanjali 
Published: June 2022

AbstractPregnancy in non-cirrhotic portal hypertension (NCPH) is an uncommon condition. Its management is challenging both to the obstetricians as well as to the gastroenterologists due to the lack of more extensive studies and standard clinical practice guidelines. These patients are at increased risk of portal hypertension (PTH) complications, especially variceal bleeding, and with an increased incidence of adverse maternal and fetal outcomes. Hence, a multidisciplinary approach is required for management of pregnancy in NCPH. This short review describes the different aspects of pregnancy with NCPH, emphasizing specific strategies for preventing and managing PTH from the preconceptional period to postpartum.
Antiepileptic Drug Adverse Cutaneous Reaction in Childhood
Authors: Yimenicioğlu Sevgi , Ekici Arzu , Türkeli Ahmet , Bildirici Yasar 
Published: June 2022

AbstractAntiepileptic drug (AED) side effects can result in treatment failure, morbidity, and mortality. Adverse cutaneous drug reactions (ACRs) frequently occur within the first 2 to 3 months of drug use. We wanted to discuss antiepileptic ACRs in childhood in this study. This was a study of 37 pediatric patients who were diagnosed with ACR and treated with AED in the last 5 years. Over a 5-year period, 37 (1.8%) of the 2,064 epilepsy patients had ACRs. There were 23 (62%) male patients and 14 (38%) female patients. Patients had a median age of 6 years (interquartile range: [IQR]: 3.5–10). The ACRs occurred in a median of 20 (IQR: 14–30) days. There were 28 (75%) patients receiving monotherapy and 9 (25%) patients receiving polytherapy. Overall, 22 (59.5%) of the 37 patients used aromatic drugs (AD), while 15 (40.5%) used nonaromatic drugs (NAD). Morbilliform eruptions accounted for the majority of ACRs (84%). Valproic acid (54%) was the most frequently used AED that resulted in ACRs. There was no significant difference in terms of eruption time, gender, or age between AD and NAD. Within 1 to 2 months of initiating a new AED, patients should be closely monitored for ACRs. If an ACR develops for one AED, greater caution should be taken when initiating the other AED. Although it is well established that ADs cause more skin reactions, we found that one of the NADs, valproic acid, causes more skin reactions.
Effects of the COVID-19 Pandemic on Spinal Fusion Procedures for Spinal Infections in a Nationwide Hospital Network in Germany
Authors: Abduljawwad Nehad , Pamnani Sunisha , Stoffel Michael , Kraft Clayton N. , Hegewald Aldemar A. , Dörre Ralf , Heese Oliver , Gerlach Rüdiger , Rosahl Steffen , Maier Bernd , Burger Ralf , Wutzler Sebastian , Carl Barbara , Ryang Yu-Mi , Hau Khanh Toan , Stein Gregor , Gulow Jens , Kuhlen Ralf , Hohenstein Sven , Bollmann Andreas , Dengler Julius 
Published: June 2022

Abstract
Background The full impact of the COVID-19 pandemic on surgical spine care is difficult to assess due to a lack in nationwide evidence from more recent phases of the pandemic. We aimed to describe changes in in-hospital processes associated with spinal fusion procedures in the treatment of spinal infections (SI) during different phases of the pandemic.
Methods In this retrospective observational study, we examined the in-hospital prevalence and outcomes of spinal fusion procedures for SI (along with patient characteristics, rates of transfer to intensive care units, and mortality rates) during the first four waves of the pandemic compared with the corresponding prepandemic periods in 2019. We used administrative data from a nationwide network of 76 hospitals managing 7% of all in-hospital cases in Germany.
Results We observed no significant change in the prevalence of SI fusion procedures during the pandemic, neither in total numbers (349 vs. 373) nor for each wave separately. On a patient level, we found no differences in age, sex, and the prevalence of paresis, and no relevant differences in associated comorbidities. The rate of mechanical ventilation did not change during any of the examined pandemic waves: it ranged between 9.5 and 18.6% during the pandemic and 3.1 and 16.0% during the corresponding prepandemic control periods. The rate of transfer to intensive care changed only during wave 4 (from 70.4 to 54.8%; p = 0.046) but not in any other pandemic phases. We observed no changes in in-hospital mortality rates (range: 2.9–9.7% vs. 6.2–11.3%) or in duration of hospital stay (range: 26.2–30.8 days vs. 20.8–29.2 days).
Conclusions The main finding of our study is that within this nationwide network of spine care centers in Germany, the delivery of surgical treatment of SI by means of spinal fusion procedures was maintained throughout the first four waves of the pandemic. Furthermore, there were no relevant changes in patient demographics, in-hospital processes, and mortality rates.
Demonstration of 621-nm-wavelength InGaN-based single-quantum-well LEDs with an external quantum efficiency of 4.3% at 10.1 A/cm2
Authors: Iida Daisuke , Kirilenko Pavel , Velazquez-Rizo Martin , Zhuang Zhe , Najmi Mohammed A. , Ohkawa Kazuhiro 
Published: June 2022

Here, we report highly efficient InGaN-based red light-emitting diodes (LEDs) grown on conventional c-plane-patterned sapphire substrates. An InGaN single quantum well active layer provides the red spectral emission. The 621-nm-wavelength LEDs exhibited high-purity emission with a narrow full-width at half-maximum of 51 nm. The packaged LED’s external quantum efficiency, light-output power, and forward voltage with a 621 nm peak emission wavelength at 20 mA (10.1 A/cm2) injection current were 4.3%, 1.7 mW, and 2.96 V, respectively. This design development represents a valuable contribution to the next generation of micro-LED displays.
What more can empirical contextual data tell about the real usage of words and collocations?
Authors: Kit Chunyu , Lu Ying , Liu Meichun 
Published: June 2022

Abstract
This article presents a corpus-based distributional analysis of the usage patterns of a cluster of words and compounds containing the morpheme qià (恰) ‘just, exactly’, by the aid of an extended concordancer to retrieve representative collocations from their adjacent contexts in Chinese Gigaword. Upon a survey of the historical evolution of the qià cluster with exemplar data and an overview of existing proposals to account for their usages in terms of expectational match, our distributional analysis is conducted to identify the salient collocational or contextual features that lead to a number of interesting findings. Substantial evidences are provided for clarifying the non-word status of qià rú (恰如) and qià sì (恰似) and their similarities, the exchangeability of qiàhǎo (恰好) and qiàqiǎo (恰巧), distinct collocational preferences of the adverbs qià (恰), qiàqià (恰恰) and the others with different subsets of verbs, the prosodic requirement of an even number of syllables for a qià-adverb and its main verb, and the contrastive popularity of qiàqià (恰恰) vs qiàdàng (恰当) to reveal different usage tendencies between speakers in Taiwan and the Mainland. All these novel findings and insights about the subtle (dis)similarities in the usage and meanings of the qià (恰) cluster suggest that distributional analysis of contextual collocations using large-scale language data remains a powerful tool that can complement other analytical approaches for the advancement of lexical semantic research.
Relevance
Authors: Wharton Tim 
Published: June 2022

AbstractDeirdre Wilson (2018)provides a reflective overview of a volume devoted to the historic application of relevance-theoretic ideas to literary studies. She maintains a view argued elsewhere that the putative non-propositional nature of (among other things) literary effects are an illusion, a view which dates to Sperber and Wilson (1986/1995: 224): “If you look at [non-propositional] affective effects through the microscope of relevance theory, you see a wide array of minute cognitive [i.e., propositional] effects.” This paper suggests an alternative, that modern-day humans have two apparently different modes of expressing and interpreting information: one of these is a system in which propositional, cognitive effects dominate; the other involves direct, non-propositional effects. The paper concludes by describing two ways such affects might be assimilated into relevance theory. The first, to accept that humans are much more than merely cognitive organisms; the second, to rethink quite radically what we mean by cognition.
Pragmatic resolutions of temporal and aspectual mismatches
Authors: Saussure Louis de 
Published: June 2022

AbstractThis paper proposes a pragmatic solution to utterances where the various indicators of time and aspect (tenses, lexical-conceptual features of Aktionsart, adverb phrases and contextual cues) seem to have divergent temporal reference and aspectual properties. This type of cases is usually treated at the semantic level as ‘mismatches’ and resolved compositionally through logical operations of ‘aspectual coercion’. We suggest on the contrary that no such effect of ‘mismatch resolution’ or ‘coercion’ is at work: these utterances are worked out inferentially according to the various pieces of evidence they provide for their relevance, in line of Deirdre Wilson’s and Dan Sperber’s (1995) relevance theory. Such utterances give rise to cognitive effects that are hardly attainable by apparently more literal formulations, while being cost-effective. Our analysis follows the work ofEscandell-Vidal and Leonetti (2011)about the rigidity and thus prevalence of computational linguistic expressions, called ‘procedural expressions’ byBlakemore (1987)withinSperber and Wilson’s (1995[1986])framework, relevance theory.
Arctic curves of the 6V model with partial DWBC and double Aztec rectangles
Authors: de Kemmeter Jean-François , Debin Bryan , Ruelle Philippe 
Published: June 2022

Abstract
Previous numerical studies have shown that in the disordered and anti-ferroelectric phases the six-vertex (6V) model with partial domain wall boundary conditions (DWBC) exhibits an arctic curve whose exact shape is unknown. The model is defined on a s × n square lattice (s ⩽ n). In this paper, we derive the analytic expression of the arctic curve, for a = b = 1 and

c
=

2

(Δ = 0), while keeping the ratio s/n ∈ [0, 1] as a free parameter. The computation relies on the tangent method. We also consider domino tilings of double Aztec rectangles and show via the tangent method that, for particular parameters, the arctic curve is identical to that of the 6V model with partial DWBC. Our results are confirmed by extensive numerical simulations.
Development of a microclimate control system for a quail farm
Authors: Kostarev S N , Sereda T G , Novikova (Kochetova) O V , Ivanova A S 
Published: June 2022

Abstract
Poultry farming in most countries of the world occupies a leading position among other branches of agricultural production. In recent years, quail breeding has become particularly relevant in Russia and European countries. Intensive growth and development, a short reproduction period, as well as meat and egg productivity, early maturity, high egg production, all this together allows them to be successfully used to obtain high quality products. At the same time, this gives grounds for the competition of quails with chickens for meat and egg productivity. Quail products are recognized as environmentally friendly, easily digestible, a rich source of valuable macro and microelements, as well as a variety of vitamins. In addition, quail eggs are a hypoallergenic product that has tonic properties and contains a large amount of protein. In terms of nutritional properties, quail eggs are healthier than chicken eggs, since they do not contain cholesterol. When growing poultry, no additional costs are required for the prevention of infectious diseases, as well as drugs that accelerate the growth of individuals. Creating optimal microclimate parameters in poultry houses is one of the important conditions for realizing poultry productivity, as well as minimizing the unit costs of material and technical resources. Violation of zoohygienic requirements for keeping quails has a significant impact not only on the productivity of poultry, but also on the health of the personnel working at the factory, as well as on environmental pollution. Microclimate control using an automated system makes it possible to provide optimal conditions for the functioning of the physiological state of individuals, which is reflected in various forms of ethological manifestations, on the reactions of eating behavior.
Multi-level diagnostics of agrarian economy subjects according to the degree of readiness for digital transformations
Authors: Nurimbetov Ravshan , Rakhimova Khavakhon , Almuradov Abdulla , Shodiyabonu Khodjaeva , Kholmuratova Guzal , Durmanov Akmal 
Published: June 2022

Abstract
Although the agricultural sector is one of the most mature sectors in the Republic of Uzbekistan, the share of agriculture in GDP is 27.9%. This indicator proves that one of the key elements of an intensive approach in the field is the problem of digitalization of agriculture. The purpose of the study is to formulate and implement a strategy for modernization of agriculture in the digital economy, to develop theoretical, methodological and organizational-methodological rules to improve the quality of network management. Based on the purpose of the study, the following tasks were identified: to assess the level of readiness of agrarian economic entities for digital transformation, taking into account the impact of external and internal environment, grouping, quantitative and scoring methods. As a result, DIGITAL-analysis was developed by grouping, quantitative and scoring methods of readiness of greenhouses for digital transformations.
The use of electropulse treatment of agricultural plants for various diseases
Authors: Bozorov E O 
Published: June 2022

Abstract
The paper considers measures to combat diseases spread by nematode viruses that infect the root system of tomatoes and cucumbers grown in closed ground and sown areas of the Republic of Uzbekistan, by installing electrical impulse discharges. The use of electropulse treatment is discussed, which does not affect the cost of harvesting, i.e. this technology does not have the results of dangerous consequences, but on the contrary, that the method of electropulse treatment effectively fights against carriers of the disease with worms. The results of experimental studies of the treatment of pathogenic plants with electropulse current discharge are analyzed, recommendations for the use of this technology are given.
Agroecological monitoring of soils in the educational and experimental farm of the Ural State Agrarian University
Authors: Vashukevich N V , Gusev A S , Varnina V A , Chulkov V A , Fedorov A N 
Published: June 2022

Abstract
The analysis of the soil cover is carried out to assess the general condition and suitability of soils for agricultural activities on it and is one of the most important indicators in the course of ecological research. The article discusses the main methods of soil cover survey on experimental fields of the Ural State Agrarian University to monitor the state of soils in this area, the results of which will be used for further research within the framework of the Ural Carbon program; the article also emphasizes the need to solve environmental problems such as greenhouse gas emissions into the atmosphere, the destruction of soil cover resulting in its fertility decrease. The necessity of monitoring the soil cover state is described on the example of one of the five test sites laid in the fields of the educational and experimental farm of the Ural State Agrarian University.
The role of industrial enterprises in ensuring food security
Authors: Tukhtabaev J Sh , Uktamov Kh F , Kukhar V S , Loretts O G , Neverova O P 
Published: June 2022

Abstract
This article highlights the role of industrial enterprises in ensuring food security. The main features of the agro-industrial cluster based on production cooperation and the distribution of land allocated for total oilseeds in Kashkadarya region were analyzed. The analysis of the yield of oilseeds in the Republic of Uzbekistan and Kashkadarya region and the efficiency of cultivation of raw cotton on farms in Kashkadarya region were analyzed. The analysis of the efficiency of the crop grown on the farm "Kholiyor Bobo ogli Kholmomin" Yakkabag district of Kashkadarya region and the efficiency of the sunflower grown on the farm "Kuvatov Shakhboz Shukhratovich" Shahrisabz district of Kashkadarya region. In addition, conclusions and recommendations on ways to develop production cooperation between enterprises of agriculture and processing industry were developed.
Genetic resistance of oat of West Siberian breeding to contrasting weather conditions and mineral nutrition level
Authors: Lyubimova A V , Moiseeva M N 
Published: June 2022

Abstract
The publication presents the results of the study of three modern common oat varieties of West Siberian breeding for response to different levels of agricultural background in contrasting moistening weather conditions. The research was carried out in the northern forest-steppe of the Trans-Urals. The soil is leached thin chernozem, medium-humus, heavy-loamy. The following varieties were studied: Talisman, Otrada, and Foma. By applying fertilizers in the experiment, the following agricultural backgrounds were created: control, without fertilizers; medium N60P20 kg/ha of active substance; increased - N90P40; high - N150P6o; very high – N200P80 kg/ha. It was found that the Otrada and Foma varieties have a higher resistance to acute arid conditions compared to the Talisman variety. In a year favorable for moisture due to mineral fertilizers, the maximum yield was obtained for: Talisman – 5.62; Otrada – 6.16 and Foma - 5.78 t/ha of grain. In acutely arid conditions, the Talisman reacted more negatively, the yield of which was equal to 2.30 t/ha. In other varieties, the yield reached 3.11 and 3.36 t/ha, respectively. During the research, it was found that the Otrada and Foma varieties belong to the group of high-intensity varieties recommended for Western Siberia. Biochemical analysis of grain and calculation of influence strength indicator showed that the protein content under the action of fertilizers increases from 6.1-7.0 to 8.4-118%, the Talisman variety had minimal response to fertilizers, where the protein content reached 10.6% only in a dry, hot year. It was revealed that the fat content in oat grain depends only on the variety – the influence strength indicator is 88.9%. The starch content is determined by the weather conditions of the year (36.1%), but varietal features are distinguished.
Information converter of seed pubescence based on software tools for the use of improved process control systems of linking
Authors: Gazieva R T , Yunusova S T , Kurbonov N M 
Published: June 2022

Abstract
The technical process of linting and preparing raw cotton for processing, when it is subjected to a series of sequential operations, which ultimately affect the indicators characterizing both the quality and quantity yield of the finished product. The purpose of the work is to increase the efficiency of the production process of lintered cotton seeds, which consists in reducing the yield of substandard cotton seeds and reducing the consumption of energy and natural resources, by including in the process control system of the genie-linter shop of the local automatic control system (ACS) of the lintering.
State regulation and the main ways to support the development of agricultural insurance in Russia and in foreign countries
Authors: Obraztsova O A , Agibalov A V 
Published: June 2022

Abstract
In our work on the basis of economic literature, statistics and scientific works in periodicals, we analyzed the international experience of conducting agricultural risk insurance in other countries, special attention was paid to issues of state support for this industry. As a result of the study, we identified the features of conducting agricultural insurance abroad, which can be further adapted to the conditions of the Russian insurance market and applied in order to improve and develop the mechanism of agricultural insurance in our country. The article also examined the dynamics of the main economic indicators of the development of the agricultural insurance market with state support. The main indicator of market development is the share of insured sown areas and livestock of farm animals. The dynamics of these indicators over the past six years has shown that the level of agricultural insurance protection in our country is at a low level, despite the fact that in 2019 there was a positive trend to the world average indicators is still very far away. Much attention was paid to indicators characterizing the level of state support for this industry in our country. As a result of research, it was determined that the agricultural risk insurance system lacks budget funds, and its development directly depends on the amount of funding. It should also be noted that large agricultural producers are mostly involved in the insurance process, and for small-scale farming, the proposed insurance products are mostly inaccessible due to the high cost. Further, the main problems of the development of the agricultural insurance mechanism were identified and directions for improving the state support system for this industry were outlined.