bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cribriform-morular variant of papillary thyroid carcinoma with poorly differentiated features: report of a case and review of the literature
Authors: Sharma Kusum L. , Singh Ravi B. , Fidda Nisreen , Lloyd Ricardo V. 
Published: January 2022

Abstract
Introduction
Cribrifrom-morular variant of papillary thyroid carcinoma (CMVPTC) is an uncommon thyroid neoplasm that occurs predominantly in women and is sometime associated with familial adenomatous polyposis (FAP). Some of these tumors may undergo dedifferentiation to poorly differentiated thyroid carcinoma (PDTC). We describe a rare case of this carcinoma in a women without a history of FAP.

Case presentation
A 49-year-old woman with a history of breast carcinoma presented with a thyroid mass. A CMVPTC was diagnosed after excision. There was no history of FAP. Histological examination showed classical features of CMVPTC in most areas, but about 20% of the carcinoma showed features of a poorly differentiated carcinoma with a solid pattern of growth, increase mitotic activity and a high Ki-67 proliferative index (25%). Immunohistochemical stains were positive for nuclear and cytoplasmic beta catenin staining. These special studies supported the diagnosis.

Conclusion
CMVPTC with dedifferentiation to PDTC is a rare carcinoma with only 4 previous documented cases in the literature. This aggressive variant of thyroid carcinoma is more common in females, as is CMVPTC, and is often associated with an aggressive biological course. The cases usually express nuclear beta catenin and estrogen, progesterone and androgen receptors have been reported in some cases. Some cases may have somatic alterations of the APC gene and TERT promoter mutations. These carcinomas may metastasize to lung, bones and lymph nodes. Because of its aggressive behavior, patient with this diagnosis should be treated aggressively to control disease spread and mortality from the carcinoma.
Efficacy of neural prolotherapy versus local corticosteroid soft tissue injection for treatment of chronic anserine bursitis: a prospective randomized clinical trial
Authors: Saba Emmanuel Kamal Aziz 
Published: January 2022

Abstract
Background
Anserine bursitis is characterized by the presence of spontaneous pain with tenderness at the inferomedial aspect of the knee joint. Neural prolotherapy aims to relieve pain of a variety of chronic musculoskeletal disorders. The study aim was to explore the short-term efficacy of neural prolotherapy (subcutaneous perineural injection of dextrose 5% solution) versus local corticosteroid injection for pain relief and improvement of function in patients with chronic anserine bursitis. The enrolled patients were randomly assigned to receive neural prolotherapy (subcutaneous perineural injection of dextrose 5% solution) (neural prolotherapy group) or a single local soft tissue injection of corticosteroid (corticosteroid group). Outcome measures included Western Ontario McMasters Universities osteoarthritis index, assessment of overall anserine bursitis pain severity using the visual analogue scale, patient’s global assessment of anserine bursitis severity using the visual analogue scale, and clinical assessment for the presence of tenderness on the anserine bursa region. Patients were evaluated before injection and after intervention by 4 weeks.

Results
The study included 67 lower limbs from 43 patients with chronic anserine bursitis. No significant differences were found between both treatment groups regarding all assessed parameters at the start of the study. After 4 weeks, within-group analysis showed that there was a statistically significant improvement in Western Ontario McMasters Universities osteoarthritis index and its subscales (P ≤ 0.0001), overall anserine bursitis pain severity (P ≤ 0.0001), and patient’s global assessment of anserine bursitis severity (P ≤ 0.0001), as well as there was significant improvement regarding the presence of tenderness at the anserine bursa region in both groups in comparison to the preinjection assessment. At the postinjection assessment, between-group analysis showed that there were no significant differences regarding all assessed outcome parameters. All patients in both groups tolerated the injection procedure and were satisfied with the procedure. There was no significant difference between the two groups regarding patients’ satisfaction to the procedure results. Improvement was achieved in 86.4% of patients included in the neural prolotherapy group versus 95.2% of patients included in the corticosteroid group.

Conclusions
Neural prolotherapy was effective in relieving pain, improving local tenderness and function in patients with chronic anserine bursitis similar to local corticosteroid injection.

Trial registration
ClinicalTrials.gov, registration number: NCT04509440. Registered 12 August 2020—Retrospectively registered,
The Optimism–Pessimism Short Scale–2 (SOP2): a comprehensive validation of the English-language adaptation
Authors: Nießen Désirée , Groskurth Katharina , Kemper Christoph J. , Rammstedt Beatrice , Lechner Clemens M. 
Published: January 2022

AbstractThe Optimism–Pessimism Short Scale–2 (SOP2) described in this article measures the psychological disposition of optimism with two items. SOP2 is the English-language adaptation of an originally for the German language developed scale. Because an empirical validation of this English-language SOP2 was hitherto lacking, the aim of the present study was to assess the psychometric properties (objectivity, reliability, validity) of the English-language adaptation and to investigate measurement invariance across both language versions using heterogeneous quota samples from the UK and Germany. Our results show that the English-language adaptation has satisfactory reliability coefficients and is correlated with 10 external variables in the study (e.g., self-esteem, Emotional Stability, life satisfaction). Moreover, scalar measurement invariance of the scale holds when comparing the UK and Germany, implying the comparability of latent (co)variances and latent means across the two nations. As an ultra-short scale with a completion time of < 20 s, SOP2 lends itself particularly to the assessment of dispositional optimism in survey contexts in which assessment time or questionnaire space are limited. It can be applied in a variety of research disciplines, such as psychology, sociology, or economics.
Enhancing corrosion resistance of RC pipes using geopolymer mixes when subjected to aggressive environment
Authors: Omer Lamiaa M. , Gomaa Mohamed S. , Sufe Waleed H. , Elsayed Alaa A. , Elghazaly Hany A. 
Published: January 2022

AbstractThe durability of reinforced concrete (RC) pipes depends upon the corrosion resistance of the reinforcing steel and the resistance of concrete mixes against an aggressive environment. This research paper aims to compare the performance of R.C. pipes made of ordinary Portland cement (OPC) concrete mixtures with others made of two different geopolymer concrete mixes based on different ratios of granulated blast furnace slag (GBFS), fly ash (FA), and pulverized red brick (RB) subjected to three different environments, ambient, tap water (TW), and an aggressive environment, and a solution of 10% magnesium sulfates + 5% chloride (MS-CL). An accelerated corrosion setup has been applied to accelerate the corrosion process in the tested samples. The evaluation of change of compressive strength of concrete and microstructure of different mixes was investigated too. Fourier transform infrared (FTIR) spectroscopy has been studied on all pipes. Geopolymer concrete mixes based on 90% GBFS and 10% RB show better results in all cases. Geopolymer concrete mixes based on 63% GBFS, 27% FA, and 10% RB increase the concrete compressive strength in the magnesium sulfate and chloride environment by 5% compared to tap water. It can be concluded that the geopolymer concrete mixes produced of 90% GBFS and 10% RB perform well under all environments, and its microstructure shows stable behavior in an aggressive environment.
ECOLOGICAL PLASTICITY AND STABILITY OF PROSPECTIVE PEA LINES
Authors: Shakirzyanova Mariya 
Published: January 2022

The studies were carried out in order to assess the parameters of the adaptability of promising pea samples in terms of yield to identify the best genotypes for the conditions of middle Volga region. The work was carried out in 2018-2020 in the central zone of Ulyanovsk region. The object of the research was 10 pea samples, the standard was Ukaz variety. According to the methods of S.A. Eberhart, W.A. Russell, V.V. Khangildina and S.P. Martynova determined the adaptability of breeding samples using the following indicators: coefficient of variation (V%), homeostaticity (Hom), breeding value (Sc), stability index (Sj2), linear coefficient regression (bi), point stability estimate (Hi). On average, over three years of research, the greatest increase in yield, compared to the standard, was noted for Ulyanovskiy yubileiny variety - 0.43 t/ha. The genotypes of Ulyanovskiy yubileiny, Viridis and line 657/14 with the smallest values of the coefficients of variation -
14.6, 22.4, 23.4%, respectively, are attributed to the most stable in terms of the coefficient of variation V. The most valuable in terms of plasticity and stability were the Ukaz variety (bi=1.15 and Sj2=0.02) and line 559/11 (1.14 and 0.00 respectively). Line 621/14 (bi=1.42 and Sj2=0.15) was recognized as an intensive variety with very low phenotypic stability and line 752/14
(1.29 and 0.11 respectively), with a reduced variety. Lines 215/11, 533/14, 657/14 were distinguished by very high phenotypic stability (bi=0,91…1,07, Sj2=0,00…0,03). The highest level of homeostaticity in combination with breeding value was observed in the promising pea cultivar Ulyanovskiy Yubileiny (Hom=15.33 and Sc=1.67) and line 215/11 (Hom=7.74 and Sc=1.22). According to the point assessment of Hi stability, significant advantages were revealed in Ulyanovskiy yubileiny variety
(Hi =4.22) and line 215/11 (1.33). According to the sum of the ranks of the six parameters of adaptability, the leading positions were occupied by lines 533/14 (27), 215/11 (32) and promising varieties Ulyanovskiy yubileiny (32), Viridis (32). According to the test results, two samples in 2020 were submitted for state variety testing
Estimating intracranial pressure using pulsatile cerebral blood flow measured with diffuse correlation spectroscopy: erratum
Authors: Ruesch Alexander , Yang Jason , Schmitt Samantha , Acharya Deepshikha , Smith Matthew A. , Kainerstorfer Jana M. 
Published: January 2022

In our original published article, we labeled the x-axis in
Fig. 1(b) incorrectly
[Biomed. Opt.
Express 11, 1462
(2020)10.1364/BOE.386612]. The sub-figure reports
the importance of features extracted from the waveforms in training a
machine learning algorithm to estimate intracranial pressure. This
erratum corrects the labels in Fig. 1(b). The discussion and conclusions drawn from
this article did not change.
Management commitment and corporate sustainability integration into small and medium-scale enterprises: A mediation effect of strategic decision-making
Authors: Adda Godfrey , Dokor Ghulam Ahmed Bin , Azigwe John Bosco , Odai Nii Afotey 
Published: January 2022

Corporate sustainability practices are vital to business survival. Hence, the need for targeted sustainable actions and corporate strategies capable of stimulating competitive advantage in terms of profitability and long-term existence of business entities. To this end, the study examines the influence of management commitment as an organisational factor on corporate sustainability integration in Ghana using corporate strategic decision-making as a mediating variable. Primary data was collected from SME owners and managers in Ghana; and the Warp partial least squares (PLS) estimation technique of the Structural Equation Model (SEM) was adopted for the analysis. The study makes a significant contribution to theory and knowledge in the context of SMEs within the corporate sustainability discourse. The study is situated on the empirical literature on the relevant concepts. This is followed by the methodology, analysis, discussions, findings, conclusions, contribution to knowledge, managerial implications, recommendations and limitations, followed by direction for future studies.
Expression of CDK9 in endometrial cancer tissues and its effect on the proliferation of HEC-1B
Authors: Yang Wen , Liu Shaoyan , Luo Qiuping , Tan Xuexian 
Published: January 2022

Abstract
Endometrial cancer (EC) is one of the most common malignant tumors in the female reproductive system, which has been threatening the life and health of many women. Its incidence and mortality rate remain high, resulting in a low survival rate. In this study, the expression of cyclin-dependent kinase 9 (CDK9) in EC tissues was investigated, and its effect on the proliferation of EC cell line HEC-1B was preliminarily analyzed. RT-qPCR and Western blotting showed that CDK9 mRNA and protein were significantly reduced in the small interfering (si)RNA interference group compared with the siRNA control and blank control groups. MTT assay showed that the EC cell proliferative ability was significantly decreased, and phosphorylated-phosphatidylinositol 3 kinase (p-PI3K)/PI3K and phosphorylated-protein kinase B (p-AKT)/AKT were significantly reduced in the siRNA interference group compared with the siRNA control and blank control groups. In conclusion, the high expression of CDK9 is a factor of poor prognosis in EC, and the reduction of CDK9 can inhibit HEC-1B cell proliferation, which may be related to the inhibition on the activation of the PI3K/AKT signaling pathway.
A corpus-based study of the ADJ-looking adjectivization in English
Authors: Guo Man , He Qingshun 
Published: January 2022

Abstract
This article aims to conduct a corpus-based study of the diachronic and synchronic distributions of a special type of participle adjectivization, the ADJ-looking adjectivization. The study based on the Corpus of Historical American English (COHA) finds that this process of adjectivization consists of two phases: (1) The downward rank-shift from the look ADJ construction to the ADJ looking adjectivization is a process of metaphorization; (2) The transcategorization from the ADJ looking adjectivization to the ADJ-looking adjectivization is a process of lexicalization. The study based on the Corpus of Contemporary American English (COCA) finds that ADJ-looking adjectivizations are mode and register sensitive but not discipline sensitive. The modifier use prefers to occur more in hard science texts to increase the complexity of nominal groups and the predicative use prefers to occur more in soft science texts to increase the grammatical intricacy of sentences. The reason for the non-sensitivity across disciplines is that evaluative adjectives tend to occur in neither soft nor hard science texts.
A review on 3D printing in tissue engineering applications
Authors: Mani Mohan Prasath , Sadia Madeeha , Jaganathan Saravana Kumar , Khudzari Ahmad Zahran , Supriyanto Eko , Saidin Syafiqah , Ramakrishna Seeram , Ismail Ahmad Fauzi , Faudzi Ahmad Athif Mohd 
Published: January 2022

Abstract
In tissue engineering, 3D printing is an important tool that uses biocompatible materials, cells, and supporting components to fabricate complex 3D printed constructs. This review focuses on the cytocompatibility characteristics of 3D printed constructs, made from different synthetic and natural materials. From the overview of this article, inkjet and extrusion-based 3D printing are widely used methods for fabricating 3D printed scaffolds for tissue engineering. This review highlights that scaffold prepared by both inkjet and extrusion-based 3D printing techniques showed significant impact on cell adherence, proliferation, and differentiation as evidenced by in vitro and in vivo studies. 3D printed constructs with growth factors (FGF-2, TGF-β1, or FGF-2/TGF-β1) enhance extracellular matrix (ECM), collagen I content, and high glycosaminoglycan (GAG) content for cell growth and bone formation. Similarly, the utilization of 3D printing in other tissue engineering applications cannot be belittled. In conclusion, it would be interesting to combine different 3D printing techniques to fabricate future 3D printed constructs for several tissue engineering applications.
Pemanfaatan Kompos Jerami Padi Guna Memperbaiki Kesuburan Tanah dan Hasil Padi
Authors: Muliarta I Nengah 
Published: January 2022

Abstrak. Tujuan dari penelitian untuk meneliti dampak kombinasi kompos jerami padi dan pupuk anorganik (phonska) terhadap kesuburan tanah dan hasil tanaman padi. Padi yang digunakan dalam penelitian ini merupakan benih padi varietas Ciherang. Penelitian dilakukan dalam wadah pot dengan ukuran diameter 24 cm dan dengan tinggi 26 cm. Setiap pot diberikan tanah 8 kg, dengan kualitas kompos yang digunakan yaitu memiliki pH sebesar 7,58, kadar air sebesar 11, 79%, rasio C/N sebesar 16,50, Kandungan C-organik sebesar 27,84%, N sebesar 1,69, kandungan P sebesar 0,23% dan K yaitu 5,04%. Kombinasi kompos jerami padi dan phonska yang digunakan dalam penelitian ini yaitu P0 (0% kompos + 0% phonska), P1 (0% kompos + 100% phonska), P2 (20% kompos + 80% phonska), P3 (40% kompos + 60% phonska), P4 (60% kompos + 40% phonska) dan P5 (80% kompos + 20% phonska). Penelitian dengan 6 perlakuan dan 4 ulangan ini menggunakan rancangan acak kelompok (RAK). Hasilnya kombinasi kompos dan pupuk phonska meningkatkan parameter fisik, biologi dan kimia tanah, namun belum mampu mengubah status kesuburan tanah. Pemanfaatan kompos yang dikombinasikan pupuk anorganik juga memberikan hasil sama dengan 100% phonska. Dimana kombinasi dosis 60% kompos + 40% phonska memberikan hasil berat gabah kering giling tertinggi dibandingkan kombinasi lainnya.Utilization of Rice Straw Compost To Improve Soil Fertility and Rice ResultsAbstract. The purpose of this study is to examine the impact of a combination of rice straw compost and inorganic fertilizer (phonska) on soil fertility and rice crop yields. The rice used in this study is the rice seed of the Ciherang variety. The research was conducted in a pot container with a diameter of 24 cm and with a height of 26 cm. Each pot is given 8 kg of soil, with the quality of compost used which has a pH of 7.58, the water content of 11.79%, C/N ratio of 16.50, C-organic content of 27.84%, N of 1.69, P content of 0.23% and K of 5.04%. The combination of rice straw compost and phonska used in this study is P0 (0% compost + 0% phonska), P1 (0% compost + 100% phonska), P2 (20% compost + 80 % phonska), P3 (40% compost + 60% phonska), P4 (60% compost + 40% phonska) and P5 (80% compost + 20% phonska). The study with 6 treatments and 4 replays used a randomized design group (RAK). As a result, the combination of compost and inorganic fertilizer (phonska) improves the physical, biological, and chemical parameters of the soil, but has not been able to change the fertility status of the soil. The utilization of compost combined with inorganic fertilizer also gives the same result as 100% phonska. Where a combination dose of 60% compost + 40% phonska gives the highest dry grain weight results compared to other combinations.
Prevalence of Overweight and Obesity among Secondary Schools Adolescents in Onitsha, Anambra State Nigeria
Authors: NV Agu , TO Ulasi , KN Okeke , JC Ebenebe , ST Echendu , CA Nriezedi , EI Nwaneli , ES Edokwe , SK Onah , CC Ifezulike , ES Umeadi 
Published: January 2022

Background: The prevalence of obesity is increasing worldwide, both in developed and developing countries. In Nigeria, obesity is emerging as an important public health problem. Childhood and adolescent obesity results in adult obesity with the resultant morbidities.
Objectives: This study determines the prevalence of overweight and obesity in apparently healthy secondary school adolescents.
Methods: This study was a cross-sectional study of secondary school adolescents aged 10-19 years randomly selected from two public schools and three private schools. The weights and heights of the study subjects were measured using standard equipment. BMI was computed using the standard formula weight (kg) / height2 (m). Using the WHO; 2007 age and sex-specific BMI percentile cut-offs, the subjects were classified as underweight (3rd to <15th percentile), normal (15th to <85th percentile), overweight (85th to <97th percentile) or obese ≥97th percentile.
Results: Data were initially collected from 1250 participants, but 52 were excluded from improperly completed questionnaires. Thus, 1198 students were ultimately included in the study, giving a response rate of 95.8%. These included 621 females (51.8%) and 577 males (48.2%) aged 10-19 years, giving an F: M ratio of approximately 1: 0.9. The mean age of the students was 15.07 ±1.96 years overall, 15.13 ± 2.08 years for males and 15.03 ± 1.83 years for females. There was no statistically significant difference between males and females in the distribution of age groups (p=0.12). The mean BMI was 21.51±3.57kg/m2 for females and 20.22±3.16kg/m2 for males. The BMI was significantly higher in females in all age groups (p<0.001) except for those aged 10-<12 years (p=0.13). The prevalence rates of overweight and obesity were 14.4% and 5.1%, respectively. The prevalence rates of overweight and obesity were significantly higher in females than males (17.7% vs 10.7%, 5.6% vs 4.5% respectively (p<0.001) and most prevalent among the early adolescence (10<12yrs; p= 0.04).
Conclusion: Prevalence of overweight and obesity is high among secondary school adolescents in Onitsha, Anambra state. There is a need for regular monitoring of weight and height as an early measure to prevent and control overweight and obesity.
Evaluation of P40 and Napsin A in the Differential Diagnosis of Non Small Cell Bronchogenic Carcinoma on Small Lung Biopsies
Authors: Singh Dr. Savita , Singh Dr. Kuldeep 
Published: January 2022

BACKGROUND :- Lung cancer is the leading cause of cancer-related mortality over word wide, Although the pathological diagnosis of lung carcinoma is limited as only small specimen available for diagnosis.the availability of targeted therapies has created a need for precise subtyping of non-small cell lung carcinoma . Several recent studies have demonstrated that the use of Immunohistochemical markers can be helpful in differentiating lung squamous cell carcinoma (LSCC) from lung adenocarcinoma (LAC) not on surgically resected material but also on small biopsy samples and cytology.
AIM (1) To classify the non small cell lung carcinoma into major categories like squamous cell carcinoma (LSCC) and adenocarcinoma (LAC) and other categories by applying immunohistochemicalmarker like p40 (truncated p63) and Napsin A
(2) To analyse the sensitivity and specificity of p40 and Napsin A in light of histomorphology and/or other relevant immunohistochemical markers available, using appropriate statistical tests.
Material and methods:- This study was a one and half year (18 months) prospective study from Jan 2017 to June 2018, conducted in department of pathology on patients attending the outpatient and inpatient department of TB and respiratory disease, a total of 210 bronchoscopic guided biopsies / transthoracic (CT/MRI /guided) small tissue biopsies from the patients suspected of lung malignancy were incorporated in the study. 20 corresponding resection specimens (wedge resection and lobectomy) were also included in the study for correlation of morphology and immunohistochemical findings on small biopsies.
RESULTS:-In our study IHC for both p40 and napsin –A aided in subtyping of 71.9% cases of non small cell lung carcinoma and this diagnostic accuracy was found to be statistically significant with p-value < 0.05.,on statistical analysis we found that napsin-A had a sensitivity of 90% and specificity of 80%. Also, positive predictive value and negative predictive value were seen to be 88.0% and 81.8% respectively.