bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’Orient tout entier en un simple bol
Authors: Warin François 
Published: November 2022

Oui, malgré le travail de déconstruction de la pensée « postcoloniale », on peut encore parler de pensée « orientale ». Comme une gageure et un défi supplémentaire, nous avons pris comme miroir d’un monde une chose, un petit rien, une technique très ancienne, un art de la terre portant le nom de « raku », art né à la croisée de plusieurs traditions du monde oriental. Par bien des aspects, cet art se distingue fondamentalement des caractères que nous attribuons à notre « Occident ». La pensée européenne est pourtant depuis longtemps entrée en rapport avec cet Orient et a tenté de lancer bien des passerelles diverses entre ces deux mondes.
La liberté d’expression : une liberté privée, politique ou sociale ?
Authors: Nouët Clotilde 
Published: November 2022

Comment comprendre la thèse selon laquelle la liberté d’expression constitue l’un des fondements d’une société démocratique, comme cela a pu être invoqué dans de nombreuses décisions constitutionnelles, en particulier en Allemagne ? L’article se propose d’éclairer la nature du lien entre liberté d’expression et démocratie en s’inscrivant dans une réflexion sur les concepts de liberté que nous mobilisons lorsque nous cherchons à penser la liberté d’expression. En s’appuyant sur les contributions de Habermas et de Honneth à ce débat, il s’attache à en décliner les différentes facettes : liberté privée, communicationnelle, droit de participation politique ou liberté sociale. Sur la base d’une compréhension de la liberté d’expression comme un droit et une pratique sociale constitutifs d’un espace public démocratique, il s’agit de poser la question de sa régulation à nouveaux frais.
Clinical Outcomes after Transcatheter Aortic Valve Replacement Stratified by Hemoglobin Levels
Authors: Al Haroun Retaj , Al Jarallah Mohammed , Rajan Rajesh , Dashti Raja , Alasousi Nader , Kotevski Vladimir , Taha Mousa Ahmed Said , Al Balool Joud , Tse Gary , Zhanna Kobalava Davidovna , Al-Saber Ahmad , Setiya Parul , Brady Peter A , Ali Almowafy Adham Hassan 
Published: November 2022

Background:
Anemia is a prevalent comorbidity in patients undergoing aortic valve replacement.

Objectives:
The objectives of this study were to define baseline parameters of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR) to determine procedural risk and mortality outcomes stratified by hemoglobin (Hb) levels.

Methods:
Retrospective study of a population of patients with severe AS undergoing TAVR with the Edwards SAPIEN 3 valve between 2018 and 2021 at Sabah Al-Ahmad Cardiac Centre, Al Amiri Hospital, Kuwait. Two cohorts were identified based on Hb level: Hb <13 and Hb ≥13 g/dl.

Results:
A total of 61 patients were included. The mean age was 73.5 ± 9.0 years, with a higher prevalence of females. The cohort with lower Hb had lower body surface area (2.0 ± 0.1 vs. 1.8 ± 0.2, P = 0.035) and bioprosthesis size (26.5 ± 1.8 vs. 24.4 ± 1.8, P = 0.001). Based on echocardiography, patients with higher Hb levels had a higher prevalence of aortic regurgitation in addition to stenosis (P = 0.029).

Conclusions:
Baseline anemia is a common comorbidity in patients with severe AS undergoing TAVR. However, in terms of procedural outcomes and mortality, Hb levels were not a predictor of post-TAVR complications or in-hospital death.
LIM domain kinase 1
Authors: Abd El Khalek Safaa M.M. 
Published: November 2022

Background
Despite recent advancement, prostate cancer (PC) remains to represent a leading cause of cancer mortality and morbidity in men. Diagnosis of PC faces many challenges, especially on core biopsies. Multiple signaling pathways have been involved in PC progression. However, castration resistance eventually develops, especially in metastatic PC. Identifying a marker that helps in distinguishing invasive tumor from benign and precursor lesions, as well as predicts its metastatic and prognostic potentials, is needed. LIM-domain kinase 1 (LIMK1) is a newly identified marker that affects the cytoskeleton of cancer cells. Its role in PC is still not well understood. This study aimed at evaluating LIMK1 expression in benign prostatic hyperplasia (30 cases), high-grade prostatic intraepithelial neoplasia (27 cases), and PC prostatic adenocarcinoma (60 cases) and its association with the prognostic clinicopathological parameters in PC.

Results
No strong expression was detected in benign prostatic hyperplasia expression compared with 25.9% and 48.3% in high-grade prostatic intraepithelial neoplasia and prostatic adenocarcinoma (Pca) groups. The expression was statistically higher in the Pca group than the other groups. There was significant association with poor prognostic parameters in Pca groups, including higher prostate-specific antigen levels, tumor percentage, Gleason scores, grade groups, T stage, positive lymph-node metastases, extracapsular extension, seminal vesicle invasion, distant metastasis, and prognostic-stage group.

Conclusion
LIMK1 is considered a promising diagnostic and prognostic marker in Pca.
Sonographic assessment of diaphragmatic thickening and excursion as predictors of weaning success in the intensive care unit: A prospective observational study
Authors: Kaur Amandeep , Sharma Shruti , Singh Vikram P. , Krishna M. Ravi , Gautam Parshotam L. , Singh Gagandeep 
Published: November 2022

Background and Aims:
Ultrasonographic assessment of diaphragmatic function can be a useful bedside tool in the weaning and extubation of mechanically ventilated patients, especially in patients with difficult weaning, in whom diaphragmatic weakness is suspected. Thus, this study was planned to assess the role of bedside sonographic assessment of diaphragmatic indices such as diaphragmatic thickening fraction (DTf) and diaphragmatic excursion (DE) in predicting successful extubation or extubation failure in weaning eligible patients by comparing the measurements with outcome.

Methods:
This prospective observational study was conducted on 50 mechanically ventilated, weaning-ready patients during the spontaneous breathing trial (SBT). The DE and DTf of patients were noted along with conventional parameters of weaning. Probability value <0.05 was considered statistically significant. Receiver operating characteristic (ROC) curves were used for analysis. Area under the curve (AUC) was measured, and sensitivity and specificity for different cut-off values were estimated.

Results:
Out of 50 patients, 15 (30%) had SBT failure and 4 had extubation failure. The group with SBT failure had significantly higher rapid shallow breathing index (RSBI) and airway occlusion pressure (P0.1s), whereas DE and DTf were lower compared to the SBT successful group. Strong correlation existed between RSBI, DTf, DE and P0.1s. DTf of nearly 24% (sensitivity 93.5%, specificity 94.7%) and DE of 1.10 cm (84% sensitivity, 89.5% specificity) were associated with best outcome.

Conclusion:
Along with conventional parameters of weaning, sonographic assessment of diaphragmatic parameters can be useful in predicting the success of SBT and in avoiding unnecessary extubation failures and thereby help in achieving a successful weaning outcome.
A study to evaluate nasotracheal intubation using Airtraq laryngoscope with a bougie and without a bougie
Authors: Bansal Teena , Singhal Suresh , Dhingra Komal 
Published: November 2022

Background and Aims:
Airtraq has been found to be useful in improving the view of the glottis. However, directing the tube tip into the glottis can be challenging during nasotracheal intubation. This problem gets resolved if the bougie is placed first. The present study was conducted for the evaluation of nasotracheal intubation using a nasal Airtraq laryngoscope with and without a bougie.

Methods:
Fifty patients of either gender, aged between 18 and 60 years, who belonged to the American Society of Anesthesiologists physical status (PS) I or II, requiring nasotracheal intubation were included. In group I (number (n) = 25), nasotracheal intubation was performed with a bougie, and in group II (n = 25), it was performed without a bougie. The primary objective was a comparison of the time taken to achieve successful nasotracheal intubation. Secondary objectives were ease of intubation and additional manoeuvres required for intubation.

Results:
The mean (± standard deviation) for time for intubation in group I was 59.24 ± 9.98 s and that in group II was 41.00 ± 4.23 s (P = 0.001). Two patients (8%) in group I and ten patients (40%) in group II required additional manoeuvres for intubation (P = 0.008). Twenty-three patients (92%) in group I and 15 patients (60%) in group II had easy intubation (P = 0.030). In group I, no patient had trauma, whereas, in group II, four patients (16%) had trauma (P = 0.030) during intubation.

Conclusion:
The time taken for nasotracheal intubation using an Airtraq laryngoscope was more with the use of a bougie as compared to the non-bougie technique. However, bougie-guided intubation was easier with less requirement of additional manoeuvres. In addition, trauma was also significantly less with the bougie technique.
Preoperative prediction of retroperitoneal lymph node involvement in clinical stage IB and IIA cervical cancer
Authors: Erdem Baki , Çelebi İbrahim , Aşıcıoğlu Osman , Akgöl Sedat , Yüksel İlkbal Temel , Özaydin İpek Yıldız , Topbaş Fitnat , Akbayir Özgür 
Published: November 2022

Objective:
Lymph node metastasis (LNM) is the most important factor affecting survival in early-stage cervical cancer (CC). International Federation of Gynecology and Obstetrics revised the staging of CC in 2018 and reported LNM as a staging criterion. We investigated the preoperatively assessable risk factors associated with LNM in surgically treated stage IB1-IIA2 CC patients.

Materials and Methods:
This was a retrospective cohort study of women who underwent radical hysterectomy and pelvic lymphadenectomy with or without para-aortic lymphadenectomy for CC stage IB1–IIA2 from 2004 to 2019. All patients included in this study were examined with speculum inspection, parametrial assessment by rectovaginal palpation under general anesthesia, transvaginal ultrasonography, magnetic resonance imaging (MRI), and chest radiography. Clinical staging was done according to the preoperative findings. MRI was used to measure tumor and lymph node dimensions.

Results:
Out of the 149 women included in the study, 29 (19.4%) had LNM. Univariate analysis revealed that larger tumor size (≥30 mm), lymphovascular space invasion (LVSI) detected with diagnostic biopsy, parametrial involvement, and deep stromal invasion status were significantly different between the group with LNM and the group without LNM. In multivariate analysis, specific preoperative risk factors such as MRI based tumor diameter ≥30 mm and LVSI (+) on the diagnostic biopsy were found to be independent risk factors for LNM in the multivariate analysis.

Conclusion:
The rate of LNM is high in patients with CC with a tumor size ≥30 mm and preoperative biopsy LVSI status even if they are clinically in early stages. Surgeons can take this into account while deciding between primary surgery and chemoradiotherapy in the treatment of CC.
Fractionated stereotactic radiotherapy as a primary or salvage treatment for large brainstem metastasis
Authors: Chatzikonstantinou Georgios , Wolff Robert , Tselis Nikolaos 
Published: November 2022

Introduction:
This study aimed to determine the efficacy and safety of robotic-based fractionated stereotactic radiotherapy (FSRT) in the treatment of large brainstem metastases (BSMs).

Methods:
Ten BSM were treated in ten patients with FSRT between January 2012 and December 2018. The median age was 61 years (range, 53–74 years) with a median Karnofsky Performance Score of 80 (range, 70–90). Four patients (40%) had received whole-brain radiotherapy prior to FSRT. The median tumor volume was 4.2 cm3 (range, 1.35–8.18 cm3) with a median prescription dose of 24 Gy (range, 16–24 Gy) delivered in 3–5 fractions (median three fractions) to the 56%–83% isodose line (median 70.5%).

Results:

1Median follow-up for the entire cohort was 14.1 months (range, 4.6–19.3 months). Five local recurrences were documented. Local control (LC) rate at 6 and 12 months was 90% and 64.2%, respectively. The median tumor volume of patients developing local recurrence was 5.42 cm3. Three patients experienced intracranial out-of-field failure for a 12-month intracranial control rate of 78.7%. Median overall survival and time to extracranial progression were 14.7 and 16.8 months, respectively. Toxicity was low with only one patient developing a new hemiparesis.

Conclusion:
Robotic-based FSRT for BSM appears to be safe with favorable LC and low toxicity even for large tumors.
Dosimetric analysis of intensity-modulated radiation therapy and volumetric-modulated arc therapy in comparison with conventional box technique in the treatment of carcinoma cervix
Authors: Bhushan Manindra , Tripathi Deepak , Yadav Girigesh , Kumar Lalit , Chowdhary Rahul Lal , Pahuja Anjali K. , Suhail Mahamood , Mitra Swarupa , Gairola Munish 
Published: November 2022

Introduction:
The number of patients for carcinoma cervix with implanted hip prostheses has been increasing worldwide during the past several decades. Technological advancements are useful for delivering higher doses, i.e., dose escalation to the target, but the presence of high-density implanted hip prosthesis creates challenges for the planner.

Materials and Methods:
A population of 25 patients was selected for the study. Plans were generated using the MONACO treatment planning system keeping the isocenter same. The parameters evaluated for planning target volume (PTV) were D98%, D50%, D2%, Dmax, Dmean, V107%, and V110%. Similarly, the parameters Dmax, Dmean, and D2cc were evaluated for the delineated critical organs. Average monitor units (TMUmean) were also assessed.

Results:
D98% of PTV was 44.51 (standard deviation [SD]: 0.13) Gy, 44.41 (SD: 0.38) Gy, 44.58 (SD: 0.14) Gy, 44.08 (SD: 0.41) Gy and 44.46 (SD: 0.32) Gy for 4F, intensity-modulated radiation therapy (IMRT), IMRT_WP, volumetric-modulated arc therapy (VMAT), and VMAT_WP techniques, respectively, where WP stands for “without prosthesis”. Volume of bowel receiving 45 Gy was 86.82 (SD: 66.38) cm3, 6.97 (SD: 5.77) cm3, 14.11 (SD: 14.29) cm3, 13.31 (SD: 6.57) cm3, and 10.31 (SD: 10.94) cm3 for 4F, IMRT, IMRT_WP, VMAT and VMAT_WP techniques, respectively.

Discussion:
Radiotherapy is standard care of practice for known cases of cervical malignancies. As per our investigations, VMAT has generated comparable plans in terms of target coverage (D98%) as compared to IMRT and 4F techniques (P = 0.015 and P = 0.002) and with prosthesis also (P = 0.024). The mean dose to the bladder was significantly lesser with IMRT and VMAT. Our results highlight that VMAT has reduced the mean dose to the rectum (P = 0.001) in presence of high-density implant. The mean dose to femoral heads was also reduced when compared with the 4-field technique.

Conclusion:
VMAT has an edge over other techniques in terms of target coverage and sparing of critical organs in the presence of metallic prosthesis. Information about the geometry and density of prosthesis will be beneficial for treatment planning.
Audit of radiation oncology practice
Authors: Mohanti Bidhu K. , Munshi Anusheel , Tharmar Ganesh , Sarkar Biplab 
Published: November 2022

Aims:
The objective of this audit was to analyze the radiotherapy (RT) practice in a newly established tertiary private hospital. With increasing radiation oncology (RO) facilities in private sector, this report is the first audit from a private health organization in India.

Subjects and Methods:
The audit of all consecutively registered patients in RO has focused to extract data from the time of RT simulation planning till the completion of RT course. The patient and disease characteristics, RT-related treatment factors and compliance were analyzed in-depth.

Results:
In this newly established RO department, the vendor-supplied equipment, e.g., RT planning system, treatment delivery (linear accelerator and brachytherapy), and RO information system (ROIS), are integrated with enterprise-wide hospital information system into unified paperless workflow management for the patient care records in a prospective manner. This analysis comprised consecutive 328 patients who consented for RT simulation and planning from April 20, 2018, to December 31, 2019. RT course compliance was 94.8% (311/328 patients), and treatment intent-wise: curative plus adjuvant in 60.2% and palliative RT in 36%. RT technique was conformal in all 100%, with volumetric arc radiotherapy (VMAT) delivered to 66.6% of patients. With overall median RT course duration of 29 days (range 1–81 days), the patients were delivered a median of 20 fractions.

Conclusions:
Compared to the previously published audit from an academic RO department in Delhi, this audit from a private hospital has shown (i) lesser waiting time, (ii) improved treatment compliance, (iii) utilization of higher techniques, and (iv) a lower duration of RT course.
Effects of local land use on riparian vegetation, water quality, and in situ toxicity
Authors: Melo Milena Perez de , Crispim Bruno do Amaral , Viana Lucilene Finoto , Lima Nathalya Alice de , Melo Elaine Silva de Pádua , Nascimento Valter Aragão do , Barufatti Alexeia 
Published: November 2022

The conversion of riparian forests into agricultural land results in the loss of water quality and aquatic biota health. The objectives of this study were therefore to determine the proportion of land use with emphasis on the type of vegetation cover; evaluate the limnological parameters and concentration of inorganic elements in the water of the São José stream in the Dourados River Basin, Mato Grosso do Sul, Brazil; correlate land use with the concentrations of inorganic elements in water; and evaluate the risk to preservation aquatic biota and in situ toxic effect on Astyanax lacustris. We collected samples from the São José Stream in 2020 and evaluated land use with high resolution aerial images. The inorganic elements in water samples were quantified using inductively coupled plasma optical emission spectrometry. In the surroundings of the São José stream, a reduction in riparian forest was observed with a proportion of only 16.32% of the area and the predominance of agricultural areas with 75.06%. The concentrations of dissolved oxygen (1.510 mg L-1) and P (> 0.235 mg L-1) in the water did not comply with the national legislation. In addition, Al and P indicated risks regarding the conservation of aquatic biota (risk quotient >1). The in situ evaluation of A. lacustris also revealed toxicity in the water. The results indicate environmental imbalance in the São José stream, requiring mitigation measures for its restoration and the sustainable use of its resources.
Keywords: anthropic action, inorganic contaminants, risks for aquatic biota.
Analisa Performa BLDC Motor untuk Ban Sepeda dengan menggunakan Solar Cell Polycrystalline sebagai Sumber Energi Matahari
Authors: Kevin Herlambang Fadio , Sariman Sariman 
Published: November 2022

Energi listrik merupakan salah satu energi yang sangat dibutuhkan dalam kehidupan. Perhatian yang lebih besar harus diberikan pada penggunaan sumber energi tak terbarukan seperti batu bara, gas alam dan minyak untuk menghasilkan listrik karena terbatasnya pasokan sumber energi tersebut dan dampak lingkungan dari limbah sisa dari proses produksi. Oleh karena itu, pilihan lain yang dapat dilakukan adalah dengan menggunakan energi terbarukan. Salah satu contoh energi terbarukan adalah energi matahari yang pemanfaatannya akan lebih berdampak positif bagi lingkungan karena energi ini dapat diperoleh dari alam dan tidak pernah habis. Kendaraan ramah lingkungan, baik kendaraan roda empat maupun roda dua berbasis teknologi hybrid dan listrik, menjadi salah satu tren di mana produsen transportasi dunia berlomba-lomba mengembangkan teknologi transportasi. Penelitian melakukan desain dan analisis numeric untuk controller sepeda motor listrik dengan motor BLDC (brushless DC Motor). Pada penelitian ini menggunakan motor BLDC dikarenakan motor BLDC lebih unggul dibandingkan dengan motor DC biasa, keunggulan-keunggulan tersebut diantaranya yaitu memiliki efisiensi yang lebih tinggi, tahan lama, tidak menggunakan sikat (brush), serta hampir tidak menghasilkan suara. Dalam percobaan pada tanggal 1 juni pada pukul 14.00 didapatkan rata-rata tegangan panel surya adalah sebesar 21,86 volt, arus panel surya sebesar 1,71 Ampere, dan menghasilkan daya sebesar 37,38 Watt, serta dari putaran motor BLDC sebesar 2215 Rpm. Rata-rata BLDC motor memutar ban sepeda disetiap selang waktu satu jam dari jam 08.00 sampai 17.00. Pada penelitian data terbaik dari penelitian ini didapatkan pada hari ke-6 pada tanggal 6 Juni 2022 dengan 3 data tertinggi yaitu arus panel 1,861 volt, daya panel 35,84 ampere, dan putaran roda 1841 Rpm.
UNFOLDING THE REALITY OF SMOKING PARADOX IN PATIENTS PRESENTING WITH STE-ACS UNDERGOING PRIMARY PERCUTANEOUS CORONARY TREATMENT
Authors: Siddiqui Maria Noor , Kumar Rajesh , Sial Jawaid Akbar , Karim Musa 
Published: November 2022

Objectives: Main objective for this study to unfold this controversy in South Asian population in terms of clinical, angiographic parameters and its in-hospital outcomes.
Methodology: In this study, we included 1756 consecutive patients diagnosed with STEMI undergoing primary PCI. Patients were classified into smokers and nonsmokers. Comparison was done on the basis of baseline characteristics, clinical presentation, angiographic features and in-hospital mortality between two groups. Multivariable logistic regression analysis was performed to evaluate the paradoxical role of smoking.
Results: Smokers were younger (53.78±11.16 years vs. 56.43±11.17 years; p<0.001) and more frequently male (98.7% vs. 69.9%; p<0.001), and had less diabetes (19.6% vs. 44.8%; p<0.001) and hypertension (38.5% vs. 64.9%; p<0.001). Smokers presented less frequently in Killip III (5.6% vs. 8.1%; p<0.001) and Killip IV (2.5% vs. 4.8%; p<0.001) in smokers group. Smokers mostly had single vessel disease (41.7% vs. 34.4%; p=0.013) whereas non-smokers had complex disease and frequently presented with total occlusion of the culprit vessel (64.6% vs. 58.8%; p=0.040). Complication such as slow flow/no-flow (24.3% vs. 33.2%; p<0.001) and cardiogenic shock (2.3% vs. 4.6%; p<0.001) were also seen less often among smokers. Smokers has significantly lesser mortality (1.8% vs. 4.3%; p=0.009) compared to non-smokers with an odds ratio (OR) of 0.41 [95% CI: 0.21-0.82, p=0.011], however, adjusted OR on multivariable analysis was 0.67 [95% CI: 0.31-1.41, p=0.290]. Independent predictors of mortality were found to be history of CVA/stroke, pre-procedure LVEDP, multi-vessel diseases, and RBS in ER adjusted OR of 3.83 [95% CI: 1.24-11.79; p=0.019], 1.07 [95% CI: 1.03-1.12; p=0.002], 2.2 [95% CI: 1.07-4.54; p=0.033], and 1 [95% CI: 1.0-1.01; p=0.032], respectively.
Conclusion: The controversial phenomenon of smoking paradox seems to be unfolded in South Asian population in post STE-ACS patients. The paradoxical protective role of smoking is confounding effect of mainly younger age, less coronary artery disease burden and complexity, lower prevalence of diabetes and hypertension and lower rate of Killip III/IV at presentation. Hence, the protective effect is insignificant in multivariable analysis and history of CVA/stroke, pre-procedure LVEDP, multi-vessel diseases, and RBS in ER were found to be independent predictors of in-hospital mortality.