bluuebunny/crossref_metadata_2025_split huggingface dataset:
Saffron (Crocus sativus L.) supplements improve quality of life and appetite in atherosclerosis patients
Authors: Ahmadikhatir Shonaz , Ostadrahimi Alireza , Safaiyan Abdolrasoul , Ahmadikhatir Shoyar , Farrin Nazila 
Published: April 2022

Background:
Atherosclerosis is the most common cause of the cardiovascular disease. Saffron is a traditional food that affects many diseases and disorders. Therefore, the aim of this study was to identify the effects of Saffron (Crocus sativus L.) on quality of life (QOL) and appetite in patients with atherosclerosis.

Materials and Methods:
This was a randomized, double-blind, placebo-controlled clinical trial. A total of 63 participants with atherosclerosis were recruited from Emam Sajjad Hospital, Valiasr Hospital, and Zafaranieyh Clinic in Tehran, Iran. The participants were divided randomly into two groups. Participants received 100 mg/d saffron or placebo capsule for 6 weeks. QOL and appetite levels were measured by the McNew QOL questionnaire, and visual analog scale questionnaire, respectively. Furthermore, anthropometric indices of participants were measured before and after the intervention.

Results:
Statistical analysis showed that there was a statistically significant difference between atherosclerosis patients who received placebo and those who consumed saffron in terms of the physical domain (P = 0.008) and social domain (P = 0.012) of QOL. In the saffron group increased score in Total score Macnew (P < 0.001), physical domain (P = 0.025), and social domain (P < 0.001) was significant after the intervention. Moreover, the consumption of saffron did not significantly affect emotional domains of QOL, and appetite levels

Conclusion:
Saffron may be considered as a novel agent in patients with atherosclerosis to improve the QOL. A great deal of further research will be needed to critically validate the efficacy of saffron and its mechanisms in atherosclerosis.
Hemoperfusion in combination with hemofiltration for acute severe organophosphorus pesticide poisoning
Authors: Zhang Minghao , Zhang Wei , Zhao Shunzhong , Tian Xiaoxi , Fu Guoqiang , Wang Boliang 
Published: April 2022

Background:
Acute severe organophosphorus pesticide poisoning (ASOPP) is one of the major diseases that endanger human life and health. However, the effects of conventional therapy including gastric lavages, mechanical ventilation, muscarinic antagonist drugs, and cholinesterase reactivators were uncertain. This meta-analysis aims to investigate the safety and efficacy of hemoperfusion combined with hemofiltration besides routine therapy for ASOPP.

Materials and Methods:
A comprehensive search for candidate publications was performed through PubMed, Medline, Cochrane Library, WanFang, Chinese Biomedical Literature, and China National Knowledge Infrastructure from database inception to May 12, 2020. The retrieved studies were screened by the predefined inclusion and exclusion criteria. The data of important end points were extracted. The risk ratio (RR) and weighted mean difference (WMD) were pooled for categorical variables and continuous variables, respectively. Meta-analyses and publication bias were conducted by using STATA software version 15.1.

Results:
A total of 11 randomized controlled trials with 811 patients were included. Compared to conventional therapy group, patients in the hemoperfusion plus hemofiltration group were significantly superior with regard to mortality (RR 0.38, 95% confidence interval [CI] [0.25, 0.57], P < 0.001), total atropine dosing (WMD −147.34 mg, 95% CI [−199.49, −95.18], P < 0.001), duration of mechanical ventilation (WMD −2.34 days, 95% CI [−3.77, −0.92], P < 0.001), cholinesterase recovery time (WMD −2.49 days, 95% CI [−3.14, −1.83], P < 0.001), and length of stay (WMD −4.52 days, 95% CI [−5.31, −3.73], P < 0.001).

Conclusion:
Combined hemoperfusion and hemofiltration was a very safe and effective treatment protocol for ASOPP, not only resulting in significantly decreased mortality but also resulting in reduced total atropine dosing, duration of mechanical ventilation, cholinesterase recovery time, and length of stay.
Clinical Characteristics and Outcome of Candidemia
Authors: Alhatmi Hind , Almansour Sarah , Abanamy Reem , Akbar Abdullah , Abalkhail Mohammed , Alharbi Ahmad , Alsaedy Abdulrahman , Mahmoud Ebrahim , Alalwan Bassam , AlJohani Sameera , Aldibasi Omar S. , Bosaeed Mohammad , Alothman Adel 
Published: April 2022

Background:

Candida bloodstream infections cause significant excess morbidity and mortality in the health-care setting. There is limited evidence regarding Candida species causing invasive infections in Saudi Arabia.

Objective:
To identify Candida species causing bloodstream infection and determine the clinical outcome and factors associated with mortality in a tertiary center in Saudi Arabia.

Materials and Methods:
This retrospective study included all cases of positive blood culture for Candida in patients admitted to King Abdulaziz Medical City, a tertiary care center in Riyadh, Saudi Arabia, between January 1, 2013 and June 30, 2019.

Results:
A total of 532 patients with candidemia were identified (male: 55.4%; mean age: 54 ± 26.2 years). The most common Candida species isolated was Candida albicans (26.7%), followed by Candida glabrata (22.7%), Candida parapsilosis (22.2%), and Candida tropicalis (18.4%). Non-albicans candidemia was more common in patients with diabetes (76.7%; P = 0.0560), neutropenia (89.8%; P = 0.0062), recent exposure to fluconazole (85.7%; P = 0.0394), and active chemotherapy (83.1%; P = 0.0128). In non-albicans, susceptibility to fluconazole varied from 95.9% with C. tropicalis to 41.5% with C. parapsilosis; nonetheless, all species were highly susceptible to echinocandins. The overall 30- and 90-day mortality rates were 39.9% and 56.4%, respectively. The mortality rate was nonsignificantly higher with non-albicans species at 30 days (41.2% vs. 35.9%; P = 0.2634) and 90 days (58.2% vs. 51.4%; P = 0.1620).

Conclusion:
This study found a changing pattern in the Candida species causing bloodstream infections and an epidemiological shift toward more non-albicans Candida species in Saudi Arabia.
Derivation and validation of a prediction model to establish nursing-sensitive quality benchmarks in medical inpatients: a secondary data analysis of a prospective cohort study
Authors: Koch Daniel , Kutz Alexander , Volken Thomas , Gregoriano Claudia , Conca Antoinette , Kleinknecht-Dolf Michael , Schuetz Philipp , Mueller Beat 
Published: April 2022

BACKGROUND: Hospitals are using nursing-sensitive outcomes (NSOs) based on administrative data to measure and benchmark quality of nursing care in acute care wards. In order to facilitate comparisons between different hospitals and wards with heterogeneous patient populations, proper adjustment procedures are required. In this article, we first identify predictors for common NSOs in acute medical care of adult patients based on administrative data. We then develop and cross-validate an NSO-oriented prediction model.
METHODS: We used administrative data from seven hospitals in Switzerland to derive prediction models for each of the following NSO: hospital-acquired pressure ulcer (≥ stage II), hospital-acquired urinary tract infection, non-ventilator hospital-acquired pneumonia and in-hospital mortality. We used a split dataset approach by performing a random 80:20 split of the data into a training set and a test set. We assessed discrimination of the models by area under the receiver operating characteristic curves. Finally, we used the validated models to establish a benchmark between the participating hospitals.
RESULTS: We considered 36,149 hospitalisations, of which 51.9% were male patients with a median age of 73 years (with an interquartile range of 59–82). Age and length of hospital stay were independently associated with all four NSOs. The derivation and validation models showed a good discrimination in the training (AUC range: 0.75–0.84) and in the test dataset (AUC range: 0.77–0.81), respectively. Variation among different hospitals was relevant considering the risk for hospital-acquired pressure ulcer (≥ stage II) (adjusted Odds ratio [aOR] range: 0.51 [95% CI: 0.38–0.69] – 1.65 [95% CI: 1.33–2.04]), the risk for hospital-acquired urinary tract infection (aOR range: 0.46 [95% CI: 0.36–0.58] – 1.45 [95% CI: 1.31–1.62]), the risk for non-ventilator hospital-acquired pneumonia (aOR range: 0.28 [95% CI: 0.09–0.89] – 2.87 [95% CI: 2.27–3.64]), and the risk for in-hospital mortality (aOR range: 0.45 [95% CI: 0.36–0.56] – 1.39 [95% CI: 1.23–1.60]).
CONCLUSION: The application of risk adjustment when comparing nursing care quality is crucial and enables a more objective assessment across hospitals or wards with heterogeneous patient populations. This approach has potential to establish a set of benchmarks that could allow comparison of outcomes and quality of nursing care between different hospitals and wards.
The Swiss Approach – feasibility of a national low-dose CT lung cancer screening program
Authors: Jungblut Lisa , Von Garnier Christophe , Puhan Milo , Tomonaga Yuki , Kaufmann Cornel , Azzola Andrea , Bürgi Urs , Bremerich Jens , Brutsche Martin , Christe Andreas , Ebner Lukas , Heverhagen Johannes T , Eich Christine , Franzen Daniel , Schmitt-Opitz Isabelle , Schneiter Didier , Spieldenner Jörg , Horwarth Nigel , Kohler Malcolm , Weder Walter , Lovis Alban , Meuli Reto , Menig Matthias , Beigelmann-Aubry Catherine , Niemann Tilo , Stöhr Susanna , Vock Peter , Senn Oliver , Neuner-Jehle Stefan , Selby Kevin , Laures Simin , Ott Sebastian , Frauenfelder Thomas 
Published: April 2022

BACKGROUND: Lung cancer is the leading cause of cancer-related deaths in Switzerland. Despite this, there is no lung cancer screening program in the country. In the United States, low-dose computed tomography (LDCT) lung cancer screening is partially established and endorsed by guidelines. Moreover, evidence is growing that screening reduces lung cancer-related mortality and this was recently shown in a large European randomized controlled trial. Implementation of a lung cancer screening program, however, is challenging and depends on many country-specific factors. The goal of this article is to outline a potential Swiss lung cancer screening program.
FRAMEWORK: An exhaustive literature review on international screening models as well as interviews and site visits with international experts were initiated. Furthermore, workshops and interviews with national experts and stakeholders were conducted to share experiences and to establish the basis for a national Swiss lung cancer screening program.
SCREENING APPROACH: General practitioners, pulmonologists and the media should be part of the recruitment process. Decentralisation of the screening might lead to a higher adherence rate. To reduce stigmatisation, the screening should be integrated in a “lung health check”. Standardisation and a common quality level are mandatory. The PLCOm2012 risk calculation model with a threshold of 1.5% risk for developing cancer in the next six years should be used in addition to established inclusion criteria. Biennial screening is preferred. LUNG RADS and NELSON+ are applied as classification models for lung nodules.
CONCLUSION: Based on data from recent studies, literature research, a health technology assessment, the information gained from this project and a pilot study the Swiss Interest Group for lung cancer screening (CH-LSIG) recommends the timely introduction of a systematic lung cancer screening program in Switzerland. The final decision is for the Swiss Cancer Screening Committee to make.
MỐI QUAN HỆ NHÂN QUẢ GIỮA LỢI NHUẬN VÀ RỦI RO CỦA CÁC NGÂN HÀNG THƯƠNG MẠI VIỆT NAM
Authors: DƯƠNG THỊ ÁNH TIÊN  
Published: April 2022

Nghiên cứu phân tích mối quan hệ nhân quả giữa lợi nhuận và rủi ro ngân hàng. Dữ liệu nghiên cứu bao gồm 32 ngân hàng ngân hàng thương mại Việt Nam, giai đoạn 2002-2020. Lợi nhuận được đo lường bằng chỉ số ROA và ROE. Rủi ro được xem xét bởi chỉ số Zscore. Tác giả sử dụng phương pháp ước lượng PVAR và kiểm định nhân quả Granger Causality để ước lượng mô hình. Kết quả nghiên cứu cho thấy, luôn tồn tại mối quan hệ nhân quả hai chiều giữa lợi nhuận (ROA) và rủi ro ngân hàng. Tuy nhiên, chỉ tồn tại mối quan hệ nhân quả một chiều giữa lợi nhuận ROE lên rủi ro tín dụng và không xảy ra chiều tác động ngược lại. Kết quả này đưa ra một số hàm ý chính sách thiết thực cho nhà đầu tư, nhà quản trị ngân hàng.
Desain Pembelajaran Kooperatif Learning Teknik Kancing Gemerincing pada Bahasa Indonesia Kelas V
Authors: Suryana Agus , Assyifa Nur Aqilah Della 
Published: April 2022

The writing of this article aims to: Explain the Design of Cooperative Learning Learning the Rattlesnake Technique in Indonesian Class V Interview Materials, Explaining the Advantages of Cooperative Learning Designs for Learning the Clinking Button Techniques in Indonesian Class V Interview Materials, This research method uses the library method by analyzing various books and journals related to Cooperative Learning Design Learning jingling button technique in Indonesian Class V Interview Material. The conclusions concluded that: The rattling button technique learning model is a learning model that has clear and systematic procedures, the rattling button learning model was originally developed by spancer Kagan in 1990. Another advantage of this jingling button technique is that students' attention can be focused, overcoming obstacles Equity distribution which is often dominated by certain students, can stimulate students to be more active and can answer all the problems that arise in the minds of each student because they take part directly, and equal distribution of responsibilities can be achieved, no member depends on his dominant partner. The steps of the cooperative learning model of the rattling button technique are (1) The teacher prepares a small box containing buttons (can also be other small objects, such as red beans, hazelnut seeds, pieces of straw, sticks, scoop of ice cream). , etc). These buttons can also be replaced with other objects, (2) Before the group starts their task, each student in each group gets two or three buttons (the number of buttons depends on the difficulty of the task given), (3) Each time a child If a child is to speak or express an opinion, he must throw away one of his buttons and put it in the middle, (4) If a child's buttons run out, he may not speak again until all his friends have also finished their buttons, (5) If all the buttons have been finished, while the task has not been completed, the group may take an agreement to divide the buttons again and repeat the procedure again.

Keywords: Kancing Gemerincing, Cooperative Learning Model Design, Indonesian Language Learning
Pembelajaran Kooperative Learning Tari Bambu pada Pelajaran Bahasa Indonesia di Madrasah Ibtidaiyah
Authors: Suryana Agus , Nurhumairoh Siti 
Published: April 2022

This article research aims to: 1. Explain the application of the concept of bamboo dance techniques, 2. Explain the advantages of bamboo dance techniques, 3. Explain the steps in designing bamboo dance techniques in Indonesian lessons. This research method uses the library method by analyzing books and journals related to the application of bamboo dance techniques. The conclusions conclude that: 1. The bamboo dance technique in learning is a technique which is a modification of the Small Circle Big Circle, due to the limitations of classroom space. 2. The advantages of bamboo dance techniques include a. Students can exchange experiences with each other in the learning process. b. Increase cooperation among students. c. Increase tolerance among fellow students. 3. The design steps for implementing the bamboo dance technique include: 1. Learning begins with the introduction of the topic by the teacher. 2. Next, the teacher divides the class into 2 large groups. If there are 40 people in one class, then each large group consists of 20 people. 3. Arrange in such a way in each large group that ten people stand in a row facing each other with 10 other people who are also in a standing position in a row. 4. After the discussion, 20 people from each large group who stood in a row facing each other shifted in a clockwise direction. 5. The results of the discussion in each large group are then presented to the whole class.
Keywords: Cooperative Learning, Bamboo Dance, Indonesian Language.
Analisis Kesulitan Siswa Dalam Mempelajari Akidah Akhlak dan Upaya Mengatasinya di MI Al-Hidayah Cibadak Sukajaya Bogor
Authors: Humaira Ernawati , Laelasari Eda , Karomah Siti 
Published: April 2022

The background of this research is that there are many factors that cause students' difficulties in learning the Akhlak Akidah at school. This research was conducted at MI Al-Hidayah Cibadak Sukajaya, Bogor Regency. The research used is descriptive qualitative, namely an attempt to provide a systematic and factual description of the situation of the incident regarding the factors, characteristics and also to explain the problem to be studied, namely the analysis of students' difficulties in studying Akidah Akhlak and efforts to overcome them. Data were collected through observation, interview and documentation techniques.The results show that there are many obstacles in the process of implementing moral aqidah learning at MI Al-Hidayah Cibadak Sukajaya, which causes students' difficulties in learning Akhlak Akidah in class III MI Al-Hidayah Cibadak Sukajaya. This is evidenced by a decrease in student activity and student learning outcomes.
Keywords: student difficulties, Akidah Akhlak, Analysis
MEMBENTUK KARAKTER RELIGIUS PESERTA DIDIK MELALUI PROGRAM MABIT (MALAM BINA IMAN DAN TAQWA) DI MAN MODEL BANDA ACEH
Authors: Muzammil Muzammil , RIJAL FAKHRUL 
Published: April 2022

Permasalah penelitian ini tentang bagaimana penerapan program Mabit (Malam Bina Iman Dan Taqwa) dalam upaya membentuk karakter religius peserta didik di MAN Model Banda Aceh. Karakter muslim yang baik merupakan komponen utama yang harus ada dalam setiap muslim. Pembinaan karakter religius peserta didik ini harus digalakkan karena melihat kondisi moral peserta didik hari ini sangat menurun sehingga salah satu diantara usaha tersebut adalah dengan melaksanakan MABIT di sekolah. Adapun tujuan dari penelitian ini adalah untuk mengetahui bagaimana penerapan MABIT di MAN Model serta dampak apa saja yang diharapkan untuk peserta didik itu sendiri. Penelitian ini bersifat kualitattif yang menggunakan metode observasi dan wawancara. Adapun hasil penelitian ini menggambarkan penerapan MABIT di MAN Model selaras dengan nilai nilai pendidikan karakter dalam islam sebagaimana yang telah dilakukan oleh Rasulullah Saw.

Abstract
The problem of this research is how the implementation of the Mabit program (Night of Building Iman and Taqwa) in an effort to form the religious character of students in the MAN Model Banda Aceh. A good Muslim character is a major component that must be present in every Muslim. The development of the religious character of students must be encouraged because seeing the moral condition of students today is very decreasing so that one of the efforts is to implement MABIT at schools. The purpose of this research is to find out how the application of MABIT in the MAN Model and what impacts are expected for the students themselves. This research is qualitative, using observation and interview methods. The results of this study describe the application of MABIT in the MAN Model is in line with the values ​​of character education in Islam as has been done by the Prophet Muhammad.
BENTUK-BENTUK PEMBERDAYAAN MASYARAKAT MISKIN OLEH BAITUL MALL DI KOTA BANDA ACEH
Authors: Juhari  , Teuku Zulyadi  
Published: April 2022

Fenomena kemiskinan tidak saja terjadi di daerah pedasaan, akan tetapi juga dialami oleh masyarakat perkotaan. Munculnya corona virus disease (covid-19) tampak semakin mendorong peningkatan angka kemiskinan khususnya masyarakat Kota Banda Aceh. Berbagai ragam geliat perekonomian masyarakat beranjak mundur seiring dengan lahirnya kebijakan pemberlakuan pembatasan kegiatan masyarakat (PKM) oleh pemerintah. Meskipun kebijakan ini bertujuan memutuskan mata rantai peredaran Covid-19, namun telah berdampak cukup signifikan terhadap pertumbuhan ekonomi masyarakat di Kota Banda Aceh. Kemiskinan memang telah menjadi persoalan umum masyarakat dunia yang tidak mudah diselesaikan, tetapi tidak bermakna tidak bisa dicarikan solusi. Baitul Mal menjadi salah satu tumpuan harapan bagi penyelesaian persoalan kemiskinan terutama dalam menjawab kemana arah pemberdayaan masyarakat dan bagaimana bentuk pemberdayaan masyarakat Kota Banda Aceh..? Untuk memperoleh data terkait arah pembinaan masyarakat ini, maka penelitian ini dilakukan secara kualitatif. Teknik pengumpulan data dilakukan dengan in-depth interview, appreciative inquiry, dan studi dokumen. Proses analisis data diperkuat dengan menghubungkannya dengan Teori Intervensi. Teori ini dipandang cukup relevan karena baitul Mal Kota Banda Aceh juga melakukan sejumlah intervensi dalam rangka memberdayakan ekonomi kerakyatan. Hasil penelitian menggambarkan bahwa baitul mal telah melakukan beberapa intervensi dalam rangka pemberdayaan masyarakat miskin dalam berbentuk colaboratif dan uswah fardiyah sehingga telah mendorong percepatan kemandirian masyarakat miskin.
Методы обучения сравнительному типологическому анализу слова
Authors: Тойчиева Насибахон 
Published: April 2022

Статья посвящена изучение вопросов бытовой лексики и выявления сравнительно-типологического анализа. Охарактеризована, что примечательностью этих исследований и аналитических наблюдений то, что вопреки касательных теоретических задач и абстрактных наблюдений, в нашей науке есть задачи практические: нужны словари, в которые включаются все или по крайней мере основные, использующиеся в реальной жизни слова, принципиальные изменения, методология применения активно употребляемых слов, общее мнение авторов и знаменитых лексикологов. В статье рассматриваются работы русских ученых, лингвистов и экспертов, в том числе Г.Н. Лукина, К.П. Смолина, М. Шанского, Б. Иомдина, Петрова.
Ключевые слова: лексикология, межстилевая лексика, разговорно-бытовая лексика, книжная лексика, лингвисты исследователи, стилистическая лексикология.
Modified Bentall procedure improves postoperative bleeding and medium-term survival
Authors: Dung Van Hung 
Published: April 2022

Background: Bentall procedure is a standard technique for complete aortic root replacements but a huge challenge is postoperative bleeding. This study was to evaluate the perioperative and long-term outcomes of the self-assembled composite graft with cuff formation for the Bentall procedure.
Methods: A retrospective study of all patients undergoing Bentall procedure with button technique was performed from 2000-2019. Group 1 included 40 patients with commercial composite graft and group 2 included 45 patients with self-assembled composite graft with cuff. Perioperative outcomes were blood loss, reoperation for bleeding, complications, and operative mortality. Long-term outcomes included overall and reoperation-free survival.
Results: Preoperative characteristics were similar in both groups, except mean age was higher in group 2 (48.2 versus 36.8 years). Group 2 significantly reduced blood loss in the first six hours postoperatively (250 versus 370 ml, P <0.001) and the risk of reoperation for bleeding (4.5% versus 17.5%, P = 0.002). Other complications were balanced between groups. Overall surgical mortality was 3. Reoperation was 7 cases. Group 2 also significantly improve the overall and reoperation-free survival: 95% and 95% (group 2) versus 75% and 70% (group 1) at four years respectively.
Conclusions: Self-assembled composite graft with cuff formation is safe and effective for Bentall procedure in the treatment of aortic root diseases with the reduction of bleeding and improvement of long-term survival. Further investigations are required to improve the feasibility and effectiveness of the procedure.