bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maluliyet Olgularının Ulusal Yönetmelikler ile Amerikan Tıp Birliği Kalıcı Engellilik Değerlendirme Kılavuzununa Göre Karşılaştırılması
Authors: Aytuğ Şahnur Serap , Gamsız Bilgin Nursel 
Published: November 2022

Objective: International classification of functioning, disability and health (ICF) was prepared by the World Health Organization to create a standard language for the definition and measurement of health and health-related states. ICF classification collects disease and disability situation sunder 3 titles as organ/system structure sand functions, activity limitations. The guide prepared by the American Medical Association has been prepared based on ICF terminology. AMA guideline calculates the disability rating according to the effects of the person’s daily and social life activities.
Methods: It is aimed to compare the regulations used in our country with the AMA guideline over the calculated disability rates. The disability rates of 315 cases who developed extremity injuries as a result of traffic accidents between 2018 and 2019 were calculated according to 3 regulations. The cases were analyzed in terms of gender, age at the time of the incident, type of accident, time between the incident and admission, injury sites, the clinics for which consultation was requested, whether the operation was performed and the complications that occurred.
Results: 81.9% of the cases were male, the mean age was 31.14 years, when we look at the disability rate values, the highest disability rates is calculated according to the SGK Regulations and the lowest disability rates calculated according to AMA guideline.
Conclusion: AMA guideline has been prepared in detail and clearly for extremity disability calculation and we think that it should be in routine practice to prevent loss of rights.
CONGENITAL ISOLATED CLEFT LIP: TECHNIQUE AND PRINCIPLES OF SURGICAL TREATMENT
Authors: Chuykin Sergey , Davletshin Nail' , Grichanyuk Dmitriy , Chuykin Oleg , Kuchuk Kristina , Bilak Anna 
Published: November 2022

Objectives. A clinical case of elimination of a rare congenital pathology in a patient with a median isolated cleft lip. Congenital cleft lip is not only a functional malformation in which the structure and function of the orbicular muscle of the mouth is impaired, but also located in an aesthetically significant place that cannot be hidden from the eyes of others. Sucking disorders and aesthetic dissatisfaction are important factors for surgical intervention as soon as possible in order to avoid problems with the social adaptation of the child and his parents in society. Medical care for congenital cleft lip should be timely, highly qualified and accessible to all children in the regions, regardless of the social and financial situation of the family. Reconstructive plastic surgery of the upper lip is the only way to eliminate a congenital cleft, which affects the quality of life, social adaptation and psychological atmosphere in the family. Cheilorhinoplasty is performed at different age periods depending on the type of defect, and the technique of operations for each type of congenital facial defect has its own characteristics. In the literature, we did not find data on the frequency of the birth of children with an isolated median cleft of the upper lip, since this is a rather rare form of congenital cleft.
Purpose. Description of the stages and basic principles of cheilorhinoplasty to restore the aesthetics and functionality of the orbicular muscle of the mouth in a rare form of congenital isolated median cleft of the upper lip.
Methodology. The paper presents the results of a clinical observation of a 5-year-old patient with congenital isolated median cleft lip and the basic principles of cheilorhinoplasty.
Conclusions. There are many types of congenital cleft lip, but adhering to the basic principles above will improve the aesthetic outcome of any upper lip reconstruction technique.
METHOD OF DIAGNOSING TEMPORO-MANDIBULAR JOINT DYSFUNCTION IN PATIENTS WITH DENTOALVEOLAR ANOMALY
Authors: Myagkova Natalia , Styazhkin Nikolay 
Published: November 2022

Subject. Anomalies of the dentition and deformities of the dentition in adult patients are often accompanied by disorders in the temporomandibular joint (TMJ). At present, the possibilities of diagnosing TMJ diseases have increased significantly due to the emergence and use of modern instrumental and technical methods. However, data on the optimal choice of research methods, their scope and sequence of execution in patients with TMJ diseases are not presented in the literature. The treatment of patients with dentoalveolar anomalies (DA), combined with functional disorders of the TMJ, according to many authors, presents significant difficulties. Currently, the problem of effective diagnosis of patients with AF and functional disorders of the TMJ remains an urgent problem in dentistry.
The aim of the study to develop a method for diagnosing patients with AF and functional disorders of the TMJ based on the method of M. Helkimo.
Methodology. Questioning and clinical examination of 150 patients aged 18–44 years with dentoalveolar anomalies and symptoms of temporomandibular joint dysfunction were carried out. According to the proposed diagnostic method, signs of TMJ dysfunction were determined: articular, muscular, neurological and occlusive. When identifying occlusal and muscle signs of dysfunction, an in-depth study was carried out according to the proposed scheme.
Results. Own observations and studies have shown that the system of signs of dysfunction of the temporomandibular joint can be used as a scheme for the initial examination of a patient with dento-maxillary anomalies and functional disorders of the TMJ at the dentist's appointment.
Conclusions. The proposed diagnostic method allows the dentist at the initial appointment, without using additional instrumental diagnostic methods, to determine the amount of necessary research for patients with dento-maxillary anomalies and functional disorders of the TMJ.
ASSESSMENT OF THE CORRELATION BETWEEN PSYCHO-EMOTIONAL STATE AND PAIN FACTOR IN PATIENTS WITH ORAL LICHEN PLANUS
Authors: Vil'danov Marat , Gerasimova Larisa , Chemikosova Tatyana 
Published: November 2022

Objectives. To evaluate the correlation between the psycho-emotional state and the pain factor in patients with oral lichen planus (OLP).
Methodology. Patients (n = 287) with various verified clinical forms of OLP of the oral mucosa (OM) and patients of the control group (without OLP) (n = 32), matched by gender and age, were studied. The levels of anxiety and depression were studied according to the Beck method, the intensity of pain sensations on a visual analog scale using author's computer programs.
Results. In the structure of the examined patients with OLP, the following clinical forms prevailed: typical form was 39.7% (n = 114), erosive-ulcerative – 31.0% (n = 89), exudative-hyperemic – 21.9% (n = 63 ), other forms – 7.4%, (n = 21).
Analysis of the correlation between pain and anxiety (BAI) and depression (BDI) revealed positive mean correlations: r = 0.5627 (95% CI 0.4754–0.6390) and r = 0.4349 (95% CI 0, 3330–0.5268), at p < 0.0001, respectively. It is worth noting that the pain factor had a 29% greater influence on the state of anxiety than on the depression factor.
Conclusion. In the complex therapy of OLP, it is necessary to take into account the psychological profile of patients, pain, understanding that these factors can be either initiating or supporting the pathological state. In view of this, the issue of an interdisciplinary approach and general planning of therapy with the involvement of specialized specialists is especially acute. The applied author's programs have shown convenience for both doctors and patients.
Management of Bacterial Blight of Clusterbean Caused by Xanthomonas axonopodis pv. cyamopsidis under Field Conditions
Authors: Jat Anita , Shekhawat P.S. , Saini K.K. 
Published: November 2022

Background: Bacterial blight pathogen (Xanthomonas axonopodis pv. cyamopsidis) of clusterbean causes considerable damage every year during Kharif season and sometimes become very severe, which results in heavy loss in grain yield. Methods: On the basis of in vitro studies, most effective botanical, antibiotic and fungicide at highest concentration were used as individual and its combinations in field experiment during two consecutive years Kharif 2018 and 2019. Seeds of clusterbean cultivar RGC-936 were artificially inoculated with X. axonopodis pv. cyamopsidis by soaking in bacterial cell suspension (2.5x108 cfu/ml) for 30 min and dried under shade. The artificially inoculated seeds were used for sowing in field trial Result: Field evaluation, the combined treatment, seed treatment with streptocycline @ 250 ppm followed two foliar sprays of streptocycline @ 250 ppm and 1st foliar spray of copper oxychloride @ 0.3 per cent and 2nd foliar spray of streptocycline @ 250 ppm at 15 days interval was found the most effective in reducing the per cent disease severity and increasing the grain and fodder yield in clusterbean.
Does the selective serotonin reuptake inhibitor (SSRI) fluoxetine modify canine anxiety related behaviour?
Authors: Echeverri Nicole , Govendir Merran 
Published: November 2022

PICO question
Does administration of the selective serotonin reuptake inhibitor (SSRI) fluoxetine reduce the severity and / or frequency of some anxiety related behaviours in companion dogs, of at least 8 months of age, when compared with no pharmacological treatment?

Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
Two studies, both randomised, were critically appraised. Each had a placebo control group and the dog's owners were blinded to the treatments
Strength of evidence
Moderate
Outcomes reported
Both studies provide moderate evidence that fluoxetine, when dispensed at 1–2 mg/kg per day by oral administration and not involving a behavioural modification program for the patient, may reduce some behaviours associated with separation anxiety and / or compulsive disorders. Both studies indicate that a reduction in some unwanted behaviours may be observed after 1 week of fluoxetine medication. Both studies recommend that behavioural and environmental modifications are important adjuncts to pharmacologic treatment of dogs with either compulsive disorders or separation anxiety. Both studies also report that some dogs treated with fluoxetine experienced anorexia / decreased appetite and lethargy, although most of these effects were transient
Conclusion
The clinical recommendation is that fluoxetine at 1–2 mg/kg administered orally, once daily, may be beneficial in reducing the severity of some canine anxiety related behaviours

How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
Case Report: Management of Chronic Supurative Otitis Media Cholesteatoma Type with Recurrent Brain Abscess Complication
Authors: Ikhlas Khairani Ayunanda , Edward Yan 
Published: November 2022

Introduction: Chronic suppurative otitis media is broadly defined as chronic inflammation that involved mucose of middle ear and mastoid air cells. The most commonly encountered intracranial complication from chronic suppurative otitis media is meningitis followed by brain abscess. Antibiotics are quite effective in early and late cerebritis stage. Surgical intervention is essential once the abscess’s capsule is formed. Case Report: Reported a case of a 22-year-old male diagnosed with chronic suppurative otitis media auris dextra suspected cholesteatoma type with cerebral abscess complications. The managements are cerebral abscess drainage followed by canal wall down mastoidectomy. In patient, Recurrent cerebral abscess formed. Conclusion: Chronic suppurative otitis media with complications of cerebral abscess is treated with abscess drainage if the abscess size is >2cm and followed by canal wall down mastoidectomy. Otogenic brain abscess due to chronic suppurative otitis media can occur repeatedly if abscess antibiotic therapy was/were inadequate
Keywords: otogenic brain abscess, mastoidectomy, chronic suppurative otitis media, abscess drainage
The Performance of Hematological Parameters for Diagnosis of Acute Appendicitis in Children
Authors: Supangat Supangat , Makhmudi Akhmad , Darajat Azka , Sakinah Elly Nurus , Nugraha Muhammad Yuda , Tohari Achmad Ilham , Qodar Tegar Syaiful , Mulyono Bagus Wahyu 
Published: November 2022

Early diagnosis of pediatric appendicitis is still difficult to make and 30-40% of cases do not show typical classic symptoms. The negative appendectomy rate and the risk of perforation reach 20% so that new, easy, inexpensive and accurate additional examination is needed. This study aimed to compare platelet distribution width (PDW) and mean platelet volume (MPV) values of appendicitis and control patients. This study is retrospective case control study. Differences in MPV and PDW levels in patients with appendicitis and controls were analyzed with a t-test and determination of sensitivity, specificity and accuracy of the two markers in appendicitis diagnosis were performed by ROC analysis The mean MPV appendicitis was significantly lower (p <0.05) compared to controls (8.3 ± 1.9; 9.2 ± 1.5) while PDW of appendicitis patients did not differ significantly from controls (10.4 ± 1, 4, 10.7 ± 2.4; p> 0.05). AUC MPV as a diagnostic tool for appendicitis 0.619 with a normal limit of 6.6 fl has a sensitivity of 90% and specificity of 30%. MPV can be used for the diagnosis of appendicitis with a normal limit of 6.6 fl having a sensitivity of 90% and specificity of 30%. There was no significant difference between PDW of appendicitis patients with controls. There was no significant difference between MPV levels of patients with simple appendicitis and complications.
Keywords: Appendicitis, MPV, PDW, Platelet
Cloud Data Security through BB84 Protocol and Genetic Algorithm
Authors: Kumar Jaydip , Saxena Vipin 
Published: November 2022

In the current digitalized world, cloud computing becomes a feasible solution for the virtualization of cloud computing resources. Though cloud computing has many advantages to outsourcing an organization’s information, but the strong security is the main aspect of cloud computing. Identity authentication theft becomes a vital part of the protection of cloud computing data. In this process, the intruders violate the security protocols and perform attacks on the organizations or user’s data. The situation of cloud data disclosure leads to the cloud user feeling insecure while using the cloud platform. The different traditional cryptographic techniques are not able to stop such kinds of attacks. BB84 protocol is the first quantum cryptography protocol developed by Bennett and Brassard in the year 1984. In the present work, three ways BB84GA security systems have been demonstrated using trusted cryptographic techniques like an attribute-based authentication system, BB84 protocol, and genetic algorithm. Firstly, attribute-based authentication is used for identity-based access control and thereafter BB84 protocol is used for quantum key distribution between both parties and later the concept of genetic algorithm is applied for encryption/decryption of sensitive information across the private/public clouds. The proposed concept of involvement of hybrid algorithms is highly secure and technologically feasible. It is a unique algorithm which may be used to minimize the security threats over the clouds. The computed results are presented in the form of tables and graphs.
Effects of Castor Oil Nanoemulsion Extracted by Hexane on the Fourth Larval stage of Culex quinquefsciatus from Al Hawizeh Marsh/Iraq, and Non- Targeted Organism
Authors: Al Hilfy Alla Abd Al Hassan , Kathiar Soolaf A. , Al Shammari Hazim Idan 
Published: November 2022

The current study aims to show the importance of plant products as mosquitocides against Culex quinquefasciatus. Castor oil Nanoemulsions were subedit in various ratios including castor oil, ethanol, tween 80, and deionized water by using ultrasonication. Thermodynamic, centrifugation, PH, assay which improved that the formula of 10 ml of castor oil, ethanol 5ml, tween 80 (14 ml) and deionized water 71ml was more stable than other formulas. The stable formula of castor oil nanoemulsion was characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS). Nanoemulsion droplets were spherical in shape and were found to have a Z-average diameter of 87.4nm. A concentration of castor oil nanoemulsion 250, 350, 450, and 550 ppm were tested as larvicidal agents and bulk emulsion 1000, 1500, 2000 , and 2500 ppm were tested also and compared, against the fourth instar larvae of C. quinquefasciatus. Castor oil nanoemulsion exhibited higher activity when compared to bulk emulsion. LC50 of castor oil nanoemulsion and castor bulk emulsion were found as 291.46 and 439.19ppm after 72 h, respectively. The toxic effects of castor oil bulk and Nano emulsion was tested against non-target organism Guppy fish and found to be not toxic at the concentration which used in the study.
Cluster Analysis of Biochemical Markers as Predictor of COVID-19 Severity
Authors: Mohammed Suhayla K. , Taha Muzahem Mohialdeen , Taha Ekhlass M. , Mohammad Massara Najim Abdulla 
Published: November 2022

Numerous blood biomarkers are altered in COVID-19 patients; however, no early biochemical markers are currently being used in clinical practice to predict COVID-19 severity. COVID-19, the most recent pandemic, is caused by the SRS-CoV-2 coronavirus. The study was aimed to identify patient groups with a high and low risk of developing COVID-19 using a cluster analysis of several biomarkers. 137 women with confirmed SARS CoV-2 RNA testing were collected and analyzed for biochemical profiles. Two-dimensional automated hierarchy clustering of all biomarkers was applied, and patients were sorted into classes. Biochemistry marker variations (Ferritin, lactate dehydrogenase LDH, D-dimer, and C- reactive protein CRP) have split COVID-19 patients into two groups(severe cases and non-severe cases groups). Ferritin, lactate dehydrogenase LDH, D-dimer and CRP were markedly increased in COVID-19 patients in the first group (severe cases). Our findings imply that early measured levels of (Ferritin, lactate dehydrogenase LDH, D-dimer, and C- reactive protein CRP) are linked to a decreased probability of COVID-19 severity. Elevated levels of this biomarker may predict COVID severity development.
Awareness and knowledge of CBCT among a group of Egyptian Pediatric dentists: A questionnaire study
Authors: Elghazawy Reham K , Khalil Sarah M.S. , Sadat Shaimaa Abu El 
Published: November 2022

Abstract
Aim: To assess the knowledge and awareness of CBCT among a group of Egyptian pediatric dentists
Materials and methods: An online open-ended questionnaire with 21 items were delivered to around 300 applicants, who practice pediatric dentistry in Egypt. The questionnaire was conveyed by Facebook and distributed among different groups, via Whats app groups and messages, through emails and LinkedIn platform. Demographic, knowledge and awareness data regarding CBCT were collected. Categorical data were analyzed using chi square test followed by pairwise comparisons utilizing multiple z-tests with Bonferroni correction. The significance level was set at p ≤ 0.05.
Results: Two-hundred twenty-nine participants responded to the survey during a 2-month interval. Almost half of the respondents showed poor knowledge of CBCT, 65.2% believes that adequate teaching is not given to dental students, regarding CBCT in their universities, and 95.2% assumes that continuous education courses is required for pediatric dentists.
Conclusions: There is explicit gap in knowledge and awareness of CBCT in pediatric dental practitioners, necessitating additional CBCT education and training courses for both undergraduate and postgraduate students.
Clinical relevance: The increase of knowledge and awareness among Egyptian pediatric dentists is required, more training and tuition should be integrated in the students’ curricula in their undergraduate and post graduate stages.
Imaging immunomodulatory treatment responses in multiple sclerosis using hyperpolarized 13C metabolic magnetic resonance imaging
Authors: Guglielmetti Caroline , Cordano Christian , Najac Chloe , Green Ari , Chaumeil Myriam 
Published: November 2022

Abstract
In recent years, the ability of conventional magnetic resonance imaging (MRI) to monitor high efficacy therapies and predict long-term disability in multiple sclerosis (MS) has been challenged. Here we used hyperpolarized 13C MR spectroscopy (MRS) metabolic imaging in a MS model of inflammatory-mediated demyelinating disease with widespread demyelination of the central nervous system (CNS). We showed that hyperpolarized metabolic imaging could monitor immune cell activation by measuring hyperpolarized [1-13C]pyruvate conversion to lactate and demonstrated that this approach detected response to two existing treatments, fingolimod and dimethyl fumarate. We observed a reduction of pyruvate-to-lactate flux after treatment, that can be explained by increased pyruvate dehydrogenase activity and decrease of immune cells. In addition, we evaluated brain perfusion using hyperpolarized [13C]urea, but saw no therapy effect. In conclusion, hyperpolarized magnetic resonance spectroscopy of [1-13C]pyruvate could provide a new non-invasive way to more directly detect immunological responses to disease-modifying therapies in MS and other diseases of the CNS.