bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nature‐Inspired Biomimetic Surfaces for Controlling Bacterial Attachment and Biofilm Development
Authors: Oopath Sruthi Venugopal , Baji Avinash , Abtahi Mojtaba , Luu Trong Quan , Vasilev Krasimir , Truong Vi Khanh 
Published: December 2022

AbstractThe use of antibacterial and antifouling materials is widely being investigated to combat the increasing risk associated with bacterial infections and the evolution of drug‐resistant bacteria. Efficient antibacterial materials can be fabricated by mimicking the topography found on the surface of natural antibacterial materials. Natural materials such as the wings of cicadas and dragonflies have evolved to use the structural features on their surface to attain bactericidal properties. The nanopillars/nanospikes present on these natural materials physically damage the bacterial cells that settle on the nanostructures resulting in cell lysis and death. This article reviews the role of nanostructures found on the surface of some of these natural antibacterial and antifouling materials such as lotus leaf, cicadas and dragonflies wings, shark skin, and rose petals. These natural structures provide guidelines for the design of synthetic bio‐inspired materials. This review article also presents some novel fabrication techniques used to produce biomimetic micro‐ and nano‐structures on synthetic material surfaces. The role of size, shape, aspect ratio, and spacing between the micro/nano‐structures on the bactericidal properties is also discussed. Finally, the review is finished with the author's view on the future of the field.
The Single‐Cell Landscape of Intratumoral Heterogeneity and The Immunosuppressive Microenvironment in Liver and Brain Metastases of Breast Cancer
Authors: Zou Yutian , Ye Feng , Kong Yanan , Hu Xiaoqian , Deng Xinpei , Xie Jindong , Song Cailu , Ou Xueqi , Wu Song , Wu Linyu , Xie Yi , Tian Wenwen , Tang Yuhui , Wong Chau‐Wei , Chen Zhe‐Sheng , Xie Xinhua , Tang Hailin 
Published: December 2022

AbstractDistant metastasis remains the major cause of morbidity for breast cancer. Individuals with liver or brain metastasis have an extremely poor prognosis and low response rates to anti‐PD‐1/L1 immune checkpoint therapy compared to those with metastasis at other sites. Therefore, it is urgent to investigate the underlying mechanism of anti‐PD‐1/L1 resistance and develop more effective immunotherapy strategies for these patients. Using single‐cell RNA sequencing, a high‐resolution map of the entire tumor ecosystem based on 44 473 cells from breast cancer liver and brain metastases is depicted. Identified by canonical markers and confirmed by multiplex immunofluorescent staining, the metastatic ecosystem features remarkable reprogramming of immunosuppressive cells such as FOXP3+ regulatory T cells, LAMP3+ tolerogenic dendritic cells, CCL18+ M2‐like macrophages, RGS5+ cancer‐associated fibroblasts, and LGALS1+ microglial cells. In addition, PD‐1 and PD‐L1/2 are barely expressed in CD8+ T cells and cancer/immune/stromal cells, respectively. Interactions of the immune checkpoint molecules LAG3‐LGALS3 and TIGIT‐NECTIN2 between CD8+ T cells and cancer/immune/stromal cells are found to play dominant roles in the immune escape. In summary, this study dissects the intratumoral heterogeneity and immunosuppressive microenvironment in liver and brain metastases of breast cancer for the first time, providing insights into the most appropriate immunotherapy strategies for these patients.
Secured Nanosynthesis–Deposition Aerosol Process for Composite Thin Films Incorporating Highly Dispersed Nanoparticles
Authors: Carnide Guillaume , Champouret Yohan , Valappil Divyendu , Vahlas Constantin , Mingotaud Anne‐Françoise , Clergereaux Richard , Kahn Myrtil L. 
Published: December 2022

AbstractApplication of nanocomposites in daily life requires not only small nanoparticles (NPs) well dispersed in a matrix, but also a manufacturing process that is mindful of the operator and the environment. Avoiding any exposure to NPs is one such way, and direct liquid reaction‐injection (DLRI) aims to fulfill this need. DLRI is based on the controlled in situ synthesis of NPs from the decomposition of suitable organometallic precursors in conditions that are compatible with a pulsed injection mode of an aerosol into a downstream process. Coupled with low‐pressure plasma, DLRI produces nanocomposite with homogeneously well‐dispersed small nanoparticles that in the particular case of ZnO‐DLC nanocomposite exhibit unique properties. DLRI favorably compares with the direct liquid injection of ex situ formed NPs. The exothermic hydrolysis reaction of the organometallic precursor at the droplet‐gas interface leads to the injection of small and highly dispersed NPs and, consequently, the deposition of fine and controlled distribution in the nanocomposite. The scope of DLRI nanosynthesis has been extended to several metal oxides such as zinc, tin, tungsten, and copper to generalize the concept. Hence, DLRI is an attractive method to synthesize, inject, and deposit nanoparticles and meets the prevention and atom economy requirements of green chemistry.
An Efficient Combinatorial Synthesis of Novel Thiazolidinone‐Bis Schiff Base Hybrids Using One‐Pot Multicomponent Reaction
Authors: Preeti  , Jaiswal Anjali , Kumar Mahesh , Singh Krishna Nand 
Published: December 2022

AbstractA facile multicomponent synthesis of novel thiazolidinone‐bis Schiff base hybrids has been developed using readily available starting materials. The four‐component reaction of isothiocyanate, hydrazine, aldehyde and α‐bromoester in water readily affords thiazolidinone‐bis Schiff base hybrids, whereas the five‐component strategy involving the same reactants in the presence of boron trifluoride etherate in acetonitrile leads to the formation of the fully functionalized thiazolidinone‐bis Schiff base hybrids.
Platinum‐Catalyzed Facile Arene Hydrogenation: Dramatic Effect of Activated Carbon and Vinylsiloxane Derivatives on the Catalyst Efficiency
Authors: Motoyama Yukihiro , Ohnishi Kenta , Shibuya Hayato , Joshi Prerna , Yoshimura Masamichi 
Published: December 2022

AbstractCombination of Karstedt's catalyst or Pt(dba)2[dba: dibenzylideneacetone] with activated carbon was found to be an efficient catalyst system for the arene hydrogenation of a variety of functionalized aromatic compounds. The reaction proceeds at ambient temperature under atmospheric hydrogen pressure to afford the corresponding carbo‐ and heterocyclic compounds in good to high yields without contamination of the metallic species. The addition of activated carbon in the reaction mixture was proved to be crucial for not only sustaining the catalytic activity but also trapping the platinum species effectively after the reaction. Similar sustaining effect was observed by the addition of vinyl siloxane derivatives.
Catalytic Access to Chiral δ‐Lactams via Nucleophilic Dearomatization of Pyridine Derivatives
Authors: Somprasong Siriphong , Reis Marta Castiñeira , Harutyunyan Syuzanna R. 
Published: December 2022

AbstractNitrogen‐bearing rings are common features in the molecular structures of modern drugs, with chiral δ‐lactams being an important subclass due to their known pharmacological properties. Catalytic dearomatization of preactivated pyridinium ion derivatives emerged as a powerful method for the rapid construction of chiral N‐heterocycles. However, direct catalytic dearomatization of simple pyridine derivatives are scarce and methodologies yielding chiral δ‐lactams are yet to be developed. Herein, we describe an enantioselective C4‐dearomatization of methoxypyridine derivatives for the preparation of functionalised enantioenriched δ‐lactams using chiral copper catalysis. Experimental 13C kinetic isotope effects and density functional theory calculations shed light on the reaction mechanism and the origin of enantioselectivity.
Simultaneous Harvesting of Multiple Hot Holes via Visible‐Light Excitation of Plasmonic Gold Nanospheres for Selective Oxidative Bond Scission of Olefins to Carbonyls
Authors: Swaminathan Swathi , Bera Jitendra K. , Chandra Manabendra 
Published: December 2022

AbstractUsing visible photoexcitation of gold nanospheres we successfully demonstrate the simultaneous harvesting of plasmon‐induced multiple hot holes in the complete oxidative scission of the C=C bond in styrene at room temperature to selectively form benzaldehyde and formaldehyde, which is a reaction that requires activation of multiple substrates. Our results reveal that, while extraction of hot holes becomes efficient for interband excitation, harvesting of multiple hot holes from the excited Au nanospheres becomes prevalent only beyond a threshold light intensity. We show that the alkene oxidation proceeded via a sequence of two consecutive elementary steps; namely, a binding step and a cyclic oxometallate transition state as the rate‐determining step. This demonstration of plasmon‐excitation‐mediated harvesting of multiple hot holes without the use of an extra hole transport media opens exciting possibilities, notably for difficult catalytic transformations involving multielectron oxidation processes.
Stiffness‐Transformable Nanoplatforms Responsive to the Tumor Microenvironment for Enhanced Tumor Therapeutic Efficacy
Authors: Tao Jun , Tian Ying , Chen Dong , Lu Wei , Chen Kun , Xu Chaoli , Bao Lei , Xue Bin , Wang Tiankuo , Teng Zhaogang , Wang Lianhui 
Published: December 2022

AbstractHerein, we report, for the first time, a unique stiffness‐transformable manganese oxide hybridized mesoporous organosilica nanoplatform (MMON) for enhancing tumor therapeutic efficacy. The prepared MMONs had a quasi‐spherical morphology and were completely transformed into soft bowl‐like nanocapsules in the simulated tumor microenvironment through the breakage of Mn−O bonds, which decreased their Young's modulus from 165.7 to 84.5 MPa. Due to their unique stiffness transformation properties, the MMONs had reduced macrophage internalization, improved tumor cell uptake, and enhanced penetration of multicellular spheroids. In addition, in vivo experiments showed that the MMONs displayed a 3.79‐ and 2.90‐fold decrease in non‐specific liver distribution and a 2.87‐ and 1.83‐fold increase in tumor accumulation compared to their soft and stiff counterparts, respectively. Furthermore, chlorin e6 (Ce6) modified MMONs had significantly improved photodynamic therapeutic effect.
Organoboron Reagent‐Controlled Selective (Deutero)Hydrodefluorination
Authors: Shen Zheng‐Jia , Zhu Chen , Zhang Xiao , Yang Chao , Rueping Magnus , Guo Lin , Xia Wujiong 
Published: December 2022

Abstract(Deuterium‐labeled) CF2H‐ and CFH2‐moieties are of high interest in drug discovery. The high demand for the incorporation of these fluoroalkyl moieties into molecular structures has witnessed significant synthetic progress, particularly in the (deutero)hydrodefluorination of CF3‐containing compounds. However, the controllable replacement of fluorine atoms while maintaining high chemoselectivity remains challenging. Herein, we describe the development of a selective (deutero)hydrodefluorination reaction via electrolysis. The reaction exhibits a remarkable chemoselectivity control, which is enabled by the addition of different organoboron sources. The procedure is operationally simple and scalable, and provides access in one step to high‐value building blocks for application in medicinal chemistry. Furthermore, density functional theory (DFT) calculations have been carried out to investigate the reaction mechanism and to rationalize the chemoselectivity observed.
Rapid and Selective Photo‐degradation of Polymers: Design of an Alternating Copolymer with an o‐Nitrobenzyl Ether Pendant
Authors: Kubota Hiroyuki , Ouchi Makoto 
Published: December 2022

AbstractThe development of polymers with on‐demand degradability is required to alleviate the current global issues on polymer‐waste pollution. Therefore, we designed a vinyl ether monomer with an o‐nitrobenzyl (oNBn) group as a photo‐deprotectable pendant (oNBnVE) and synthesized an alternating copolymer with an oNBn‐capped acetal backbone via cationic copolymerization with p‐tolualdehyde (pMeBzA). The resultant alternating copolymer could be rapidly degraded into lower‐molecular‐weight compounds upon simple exposure to UV irradiation without any reactants or catalysts, while it was sufficiently stable toward heat and ambient light. This degradation proceeds via cleavage of the hemiacetal structure generated upon photo‐deprotection of the oNBn pendant. The oNBn‐peculiar degradability allowed the exclusive photo‐degradation of the oNBnVE/pMeBzA segments in a diblock copolymer composed of oNBnVE/pMeBzA and benzyl vinyl ether (BnVE)/pMeBzA segments.
Ultrasound‐assisted synthesis of silica‐coated magnetite material decorated with silver nanoparticles for the detoxification of 4‐nitrophenol
Authors: Prathibha Edwin , Rangasamy Rajmohan , Sridhar Arunasalam , Lakshmi Kannappan 
Published: December 2022

Among phenolic pollutants, 4‐nitrophenol is a common organic pollutant readily discharged in water bodies. It causes an adverse effect on the lives of human beings and aquatic species. Therefore, it is essential to remove this pollutant from water resources. Herein, we report an eco‐friendly approach for the synthesis of silica‐coated magnetite material decorated with ultra‐fine silver nanoparticles, as a magnetically recyclable catalyst for the detoxification of 4‐nitrophenol. This synthetic strategy employs only ultrasound waves throughout the preparation of catalyst material. Further, no stabilizer was added in any of the steps involved in synthesis. Initially, iron oxide nanoparticles were synthesized from ferrous sulphate heptahydrate precursor and coated with silica matrix. Subsequently, silver nanoparticles were deposited over it. Silver was chosen among the noble metal nanoparticles, as it is abundantly available and economical and exhibits good catalytic properties. This catalyst material was well characterized using HRTEM, XRD, VSM and FTIR techniques. HRTEM studies revealed that Ag nanoparticles of size between 2 and 5 nm were dispersed over the silica‐coated magnetite. The significant merits of this approach are usage of ultrasound waves, stabilizer‐free and reduced time consumption in the synthesis of catalyst. Furthermore, a facile magnetic separation of catalyst using bar magnet is noteworthy to this method. The catalyst was successfully recycled for eight times without any significant loss in the activity. This can be a promising catalyst for the treatment of wastewater contaminated with 4‐nitrophenol.
Call for environmental justice amplification among ecology scholars and practitioners: A Black Ecology perspective
Authors: Height Tatiana C. , Martin Katherine L. , Leggett Zakiya H. 
Published: December 2022

AbstractFor many ecologists, who do not identify as environmental justice scholars, the idea of including environmental justice into their work may not seem intuitive. This piece provides an overview of the foundations of environmental justice as a movement and as a branch of scholarship. The authors provide suggestions for how ecologists can include this area of scholarship into their work. Through this article, the authors hope to bridge the scholarly gap between environmental justice and ecology, using the lens of Black Ecology.
Arginase‐1+ bone marrow myeloid cells are reduced in myeloproliferative neoplasms and correlate with clinical phenotype, fibrosis, and molecular driver
Authors: Bonometti Arturo , Borsani Oscar , Rumi Elisa , Ferretti Virginia Valeria , Dioli Claudia , Lucato Elena , Paulli Marco , Boveri Emanuela 
Published: December 2022

AbstractIntroductionPhiladelphia‐negative myeloproliferative neoplasms (MPN) are clonal myeloid proliferative disorders characterized by sustained systemic inflammation. Despite its renowned importance, the knowledge concerning the inflammatory pathophysiology of these conditions is currently limited to studies on serum cytokines, while cellular immunity has rarely been investigated.MethodsIn the present study, we targeted Arginase‐1 immunosuppressive myeloid cells in the bone marrow of MPN patients and healthy controls and investigated their clinical and prognostic significance. We demonstrated that MPN are characterized by a significant reduction of bone marrow immunosuppressive cells and that the number of these cells significantly correlates with several clinical and histopathological features of diagnostic and prognostic importance. Moreover, we identified an unreported correlation between a reduction of Arginase‐1+ bone marrow cells and the presence of CALR mutations, linking tumor‐promoting immunity and molecular drivers. Finally, we postulate that the reduction of bone marrow Arginase‐1+ immunosuppressive cells may be due to the migration of these cells to the spleen, where they may exert systemic immunomodulatory function.ConclusionAltogether, this study preliminary investigated the contribution of cellular immunity in the pathogenesis of myeloproliferative neoplasms and identified a possible interesting therapeutic target as well as a set of new links that may contribute to unraveling the biological mechanisms behind these interesting hematological neoplasms.
The effect of a career adaptability psycho‐educational programme on coping with career indecision and career adaptability: A pilot study
Authors: Turan Mehmet Emin , Çelik Eyüp 
Published: December 2022

AbstractThis study aimed to examine the effects of a career construction theory‐oriented Career Adaptability Psycho‐educational Programme on career adaptability and coping with career indecision in Turkish high school students. Twenty‐six participants took part in the experimental design. A split‐plot (mixed) design of 2 × 3 (experimental/control groups X pretest/posttest/follow‐up test) was used. It was found that the Career Adaptability Psycho‐educational Programme has a significant effect on coping with career indecision and career adaptability; the same effect was found for the follow‐up measures completed 4 months later.
Kinetics of Heterogeneous Single‐Site Catalysis
Authors: Murzin Dmitry Yu. 
Published: December 2022

AbstractDespite a large number of studies focusing on single‐ site (surface organometallic, single‐atom and single‐atom alloy) catalysts much less attention is devoted to kinetic analysis of such reactions. This mini‐review addresses some kinetic features of single‐site catalysis including both qualitative and quantitative aspects.
Meso‐2‐MethoxyNaphthalenyl‐BODIPY as Efficient Organic Dye for Metallaphotoredox Catalysis
Authors: Bassan Elena , Calogero Francesco , Dai Yasi , Dellai Angela , Franceschinis Alessandro , Pinosa Emanuele , Negri Fabrizia , Gualandi Andrea , Ceroni Paola , Cozzi Pier Giorgio 
Published: December 2022

AbstractA newmeso‐naphthalenyl BODIPY was designed for the efficient generation of long‐lived triplet excited state under irradiation with green light. The new, heavy atom‐free organic chromophore was employed in a benchmark example of dual palladium and photoredox catalysis, highlighting the applications of BODIPY dyes as photoredox catalysts.
School counselor educators: A grounded theory of career interest and satisfaction
Authors: Moran David , Brookover Dana L. , Goodman‐Scott Emily 
Published: December 2022

AbstractAnnually, there are school counseling specific counselor educator positions that remain unfilled. There is a need for more counselor educators with school counseling backgrounds. This grounded theory provides a model of the process by which school counselor educators decide to enter academia and what keeps them in their positions, based on focus groups with 32 participants. Results showed the reasons for leaving school counseling, what factors promote entry into school counselor education, and what keeps school counselor educators in that role. Implications for counselor education are provided.
Impact of Microwave Heat Treatment on the Dehydration Kinetics and Properties of Gelatin Membranes
Authors: Yapinski Dominico Delven , Mak Yu Shuen , Lim Siew Shee , Hii Ching Lik 
Published: December 2022

AbstractMicrowave heating was utilized as a dehydration method to produce gelatin membranes. The results demonstrated that the moisture content reduced drastically at higher microwave power, and the effective diffusivities were determined. The specific energy consumption was recorded at a higher range for 10 wt % but an opposite trend was observed for the moisture extraction rate. The spectra of all dehydrated gelatin membranes were quite similar to that of gelatin powder. Microwave dehydration increased the disordered structure of gelatin which enhanced the amphiphilicity. The surface morphology revealed a rough membrane surface which could aid the adhesion and growth of human skin cells.
In‐situ Sacrificial Positive Additive Strategy for the Construction of a Stable Negative Interface in Dual Graphite Batteries
Authors: Zhang Li , Liu Ziqiang , Wang Gaowei , Feng Wangjun , Wang Xiaoyun , Feng Jianze , Zhang Xiaqing , Ma Hongyun , Zhang Xu , Xu Yongtai , Yao Siyuan , Ding Yunxia , Su Kailimai , Yan Xingbin 
Published: December 2022

AbstractDue to their merits of affordability, safety, and environmental friendliness, dual graphite batteries (DGBs) have drawn widespread interest as novel energy storage devices. Nevertheless, the development of DGBs is plagued by inferior cyclic stability that arise from the irreversible loss of cations and the anion‐cation crosstalk during the formation of an negative interface. We proposed an in‐situ sacrificial positive additive strategy to enhance the electrochemical performances, based on the decomposability of potassium oxalate monohydrate (K2C2O4⋅H2O). The experimental and computational results show that the positive additive can add cations to support a stable negative interface and suppress the anion‐cation crosstalk. The as‐constructed DGBs with K2C2O4⋅H2O deliver high‐rate capability (31.8 mAh g−1 at 3.0 C) and excellent cyclic stability (∼84.1 % capacity retention after 180 cycles). This work provides a new opportunity of negative interface construction for propelling the commercial evolution of the advanced DGBs.
Role of Superoxide and Singlet Oxygen on the Oxygen Reduction Pathways in Li−O2 Cathodes at Different Li+ Ion Concentration**
Authors: Tesio Alvaro Y. , Torres Walter , Villalba Matías , Davia Federico , del Pozo María , Córdoba Daniel , Williams Federico J. , Calvo Ernesto J. 
Published: December 2022

AbstractThe oxygen reduction reaction (ORR) on Au electrodes has been studied in DMSO at different Li+ concentrations. In‐operando fluorescence decay of 9,10‐dimethyl anthracene (DMA) has shown that disproportionation of lithium superoxide Li+O2− into Li2O2 and O2 leads to an increasing fraction of very reactive singlet oxygen (1O2) at high lithium concentration. Singlet oxygen has been identified as the major cause of parasitic reactions leading to capacity fading and high charge overpotential of Li−O2 batteries. Rotating ring‐disk electrode shows quantitative formation of soluble superoxide at low Li+ concentration, a decrease in superoxide yield at high Li+ concentrations is consistent with electrochemical quartz crystal microbalance (EQCM) evidence of Li2O2 deposits. Differential electro chemical mass spectrometry (DEMS) confirms oxygen depletion at the electrode surface during ORR, and O2 evolution during oxidation at 3.1 V (vs. Li/Li+ in DMSO). The spurious solvent decomposition due to the very reactive 1O2 from superoxide disproportionation is revealed by gravimetric EQCM of insoluble by‐products. Furthermore, DEMS provides evidence of CO2 gas evolution from decomposition of Li2CO3 by‐product at 3.7 V (vs. Li/Li+ in DMSO). Preliminary in‐operando full discharge‐charge tests of a Li−O2 battery with 1O2 quencher azide resulted in stable cycling, enhanced capacity and full charge recovery in a round trip.