bluuebunny/crossref_metadata_2025_split huggingface dataset:
La gobernanza del agua de riego en la región de Murcia
Authors: Gómez Espín José Mª , Gómez Gil José Mª , Gil Meseguer Encarnación 
Published: October 2022

En el cuadrante suroriental de la península ibérica, se han sucedido formas de organizarse losregantes que reciben agua de una misma toma (heredamiento de aguas, comunidad de propietarios,sociedad civil de bienes, junta de usuarios, comunidad de regantes, etc.). Son modelos de gobernanzaen la gestión de un recurso escaso como es el agua para riego. La investigación es un estudio regional,diacrónico y comparado del uso del agua para riego en la Región de Murcia, en el que se analiza lapérdida de autonomía y autogestión de los regantes en la administración del agua, para ser finalmentetutelados por el Estado a través de las confederaciones hidrográficas. Es un estudio de casos en regadíoshistóricos tradicionales de Calasparra, Molina de Segura, Librilla, Fortuna y Abanilla. Se ha realizadouna amplia búsqueda de fuentes originales en los archivos de heredamientos y comunidades de regantes,en los de varios municipios, y en el de la Confederación Hidrográfica del Segura. El trabajo de campoen los perímetros regables y las entrevistas a gestores del acopio y distribución del agua han permitido conocer las singularidades de la gobernanza entre agricultores-regantes, así como los rasgos de los paisajes culturales construidos por esos aprovechamientos de agua.
Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage
Authors: Li Jiao , Feng Yi , Zhao Jing , Fang Zhi , Liu Haiting 
Published: October 2022

Background
Angiogenesis is an endogenous repair mechanism following hypoxic-ischemic brain damage (HIBD). Interestingly, recent studies have shown that angiogenesis can be regulated by telomerase reverse transcriptase (TERT), a critical component of telomerase. As telomerase reverse transcriptase can promote angiogenesis after stroke, we hypothesized that it could also promote angiogenesis after HIBD. To test this hypothesis, we developed in vivo and in vitro HIBD models in neonatal rats.

Methods
TERT was overexpressed by lentivirus and adenovirus infection, and levels were measured using quantitative real-time polymerase chain reaction. We used a cell counting kit to quantify the proliferation rate of brain microvascular endothelial cells (BMECs), and immunofluorescence staining to measure CD34 expression levels. A microvessel formation assay was used to evaluate angiogenesis. Blood-brain barrier (BBB) integrity was assessed using immunohistochemical staining for ZO-1 and Evans Blue staining. Lastly, the expression level of Notch-1 was measured by western blotting.

Results
Overexpression of TERT promoted the proliferation of BMECs after hypoxic-ischemic damage in vitro. TERT overexpression increased the formation of microvessels in the neonatal brain after HIBD both in vivo and in vitro. Overexpression of TERT improved BBB integrity in the brains of neonatal rats after HIBD. In addition, the expression level of Notch-1 was increased in BMECs following oxygen glucose deprivation, and overexpression of TERT further increased Notch-1 expression levels in BMECs following oxygen glucose deprivation.

Discussion
Our results reveal that telomerase reverse transcriptase promotes angiogenesis and maintains the integrity of the blood-brain barrier after neonatal hypoxic-ischemic brain damage. Furthermore, the Notch-1 signaling pathway appears to contribute to the angiogenic function of telomerase reverse transcriptase. This protective effect of telomerase reverse transcriptase opens new horizons for future investigations aimed at uncovering the full potential of telomerase reverse transcriptase as a promising new target for the treatment of hypoxic-ischemic encephalopathy.
A small footprint couch‐top support device for image‐guided radiotherapy of heavy patients
Authors: Chen Huixiao , Morley Kevin , Rodriguez Ronnie , Draeger Emily , Shafiq ul Hassan Muhammad , Chen Zhe (Jay) 
Published: October 2022

AbstractPurposePatients with body weights close to or above 400 lbs present unique challenges in radiation therapy since the weight limit of most treatment couches decreases as the couch‐top extends toward the treatment gantry. The purpose of this work was to develop a small footprint couch‐top support platform to safely perform image‐guided radiotherapy (IGRT) for extremely heavy patients.MethodsOne way to protect the couch‐top from damage and prevent a catastrophic breakdown is to provide additional support as the couch extends toward the treatment gantry. To allow a maximal range of gantry movement, a small‐footprint adjustable jack stand, placed underneath the couch‐top, was chosen and modified from a commercial jack stand (with 1100 lbs capacity). The couch could be easily extended longitudinally and laterally with a modified 8‐ball‐transfer plate mounted at the top. The operation of a couch‐top support platform was used for two heavy patients after phantom testing. kV and MV imaging options and ranges were quantified.ResultsThe custom‐constructed couch‐top support platform was found to provide stable support with smooth couch shifts. The small footprint allowed gantry rotation from 133° to 227°, which would allow both fixed beam radiotherapy and partial‐arc volumetric modulated arc therapy (VMAT). For IGRT, orthogonal 2D kV‐kV image pairs with source angles of 40o and 130o were acquired and tested successfully. With the support platform, two clinical cases with patient weights greater than 415 lbs were successfully treated with image‐guided partial arc VMAT radiotherapy. The study demonstrated the safety and efficiency of using this new couch‐top support platform to prevent couch failure from treating heavy patients.ConclusionsA new couch‐top support platform has been designed, assembled, and tested for IGRT. The new support platform is easy to use, cost‐effective, and allows extremely heavy patients to be treated safely and robustly with IGRT and VMAT.
Highly Reversible Zn Metal Anodes Realized by Synergistically Enhancing Ion Migration Kinetics and Regulating Surface Energy
Authors: Wang Yang , Deng Zheng , Luo Bin , Duan Guosheng , Zheng Sinan , Sun Leilei , Ye Zhizhen , Lu Jianguo , Huang Jingyun , Lu Yingying 
Published: October 2022

AbstractThe Zn metal anode suffers from uncontrollable dendrite formation and intricate parasitic reactions that dramatically impede the commercialization of aqueous Zn metal batteries (AZMBs). This st proposes synergistic strategies for facilitating Zn2+ migration kinetics and regulating surface energy to achieve dendrite‐free Zn deposition and suppressing self‐corrosion by covering Zn anode with multifunctional covalent organic frameworks possessing sulfonate‐rich (SO3H) covalently‐tethered nanochannels (SCOFs). Benefiting from the vital interplay between SO3H and Zn2+, the SCOFs coatings form ample Zn2+ accelerated transport channels to extract Zn2+ from the electrolyte quickly, thereby promoting rapid desolvation of hydrated Zn2+, enhancing ion replenishment capability, and guaranteeing a steady stream of Zn2+ flux for endowing uniform and compact nucleation. Additionally, the zincophilic SCOFs significantly reduce the surface energy of the Zn (002) crystal plane, inducing preferentially crystallographic (002) orientation electroplating growth. Consequently, the SCOFs‐coated Zn anodes (SCOFs@Zn) demonstrate an excellent lifespan up to 4000 h at 5 mA cm−2, 1 mAh cm−2, and 3000 h at 5 mA cm−2, 2 mAh cm−2. Meanwhile, the full cell paired with the MnO2 cathode sustains remarkable reversibility within 1000 cycles. The synergistic approach to manipulating ion migration and surface energy provides new insights into developing highly stable AZMBs.
Engineering Spin Configurations of Synthetic Antiferromagnet by Controlling Long‐Range Oscillatory Interlayer Coupling and Neighboring Ferrimagnetic Coupling
Authors: Xie Xuejie , Wang Xiujuan , Wang Wei , Zhao Xiaonan , Bai Lihui , Chen Yanxue , Tian Yufeng , Yan Shishen 
Published: October 2022

AbstractControllable manipulation of specific spin configurations of magnetic materials is the key to constructing functional spintronic devices. Here, it is demonstrated by integrating the merits of ferromagnetic, ferrimagnetic, and antiferromagnetic spin configurations into one synthetic antiferromagnetic (SAF) heterostructure by controlling both long‐range oscillatory interlayer coupling and neighboring ferrimagnetic coupling. A controllable manipulation of four types of spin configurations of the Pt/[Co/Pt/Co]/Ru/CoTb SAF heterostructures composed of ferromagnetic Co/Pt/Co and ferrimagnetic CoTb layers is successfully achieved. In particular, the compensated magnetization, enhanced anomalous Hall resistance in the remanence state, wide‐temperature spin‐orbit torque switching of magnetization, and high immunity to the external magnetic field are simultaneously obtained in one of the SAF heterojunctions with macroscopic interlayer antiferromagnetic coupling. This design concept of engineering spin configurations may enable efficient spin manipulation for customized memory and logic applications.
Optimizing Fouling Resistance of Poly(Sulfabetaine)s through Backbone and Charge Separation
Authors: Karthäuser Jana F. , Koc Julian , Schönemann Eric , Wanka Robin , Aldred Nick , Clare Anthony S. , Rosenhahn Axel , Laschewsky André 
Published: October 2022

AbstractThe three dominating polyzwitterion families, polyphosphatidylcholines, polycarboxybetaines, and polysulfobetaines, all of which provide high fouling resistance, have been complemented by a fourth one recently, the so‐called polysulfabetaines that combine ammonium with sulfate moieties. To elucidate the relationship between their structure and antifouling potential, coatings of a set of systematically varied poly(sulfabetaine methacrylate)s are investigated. In particular, the effects of the spacer groups, either separating the zwitterionic units from the polymer backbone, or the cationic from the anionic charges, are explored, studying the resistance against non‐specific protein adsorption and the accumulation of single species of marine biofouling organisms. All polysulfabetaines are at least as effective, or even more potent than the structurally closely related standard poly(sulfobetaine methacrylate). Their resistance against proteins and fouling organisms can be tuned via the betaine‐to‐backbone spacer. Overall, the polysulfabetaine coatings with the shorter ethylene spacer show higher resistance against non‐specific adsorption of proteins, in particular of lysozyme, or against colonization by diatoms. This may result from the higher steric constraints of the polymer attached zwitterions, favoring particularly advantageous conformations. Moreover, a shorter spacer between the oppositely charged ionic groups of the zwitterionic moiety reduces the settlement of cyprid larvae more effectively.
Rechargeable Potent Anti‐Viral Cotton Grafted with a New Quaternized N‐Chloramine
Authors: Currie Sarah , Cutts Todd , Kasloff Samantha , Wang Weien , Holloway Kimberly , Logsetty Sarvesh , Kumar Anand , Kumar Ayush , Liu Song 
Published: October 2022

AbstractPolymeric substrates can be endowed with antiviral properties by grafting N‐chloramine precursors to the surface. These surfaces bind oxidative chlorine from a dilute chlorine bleach solution and are similarly recharged after depletion for reuse. Previously, enhanced antibacterial efficacy of quaternized N‐chloramines compared to their neutral counterparts is reported. In this study, a new quaternized N‐chloramine N1‐(3‐methacrylamidopropyl)‐N1,N1,N10,N10‐tetramethyl‐N10‐(2,2,6,6‐tetramethylpiperidin‐4‐yl)decane‐1,10‐diaminium (MAMPIP) featuring two quaternary ammonium groups within the structure to boost the chlorination efficiency and achieve excellent antiviral efficacy against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is reported. Antiviral fabrics are prepared by free‐radical graft polymerization of MAMPIP, or copolymerization of MAMPIP with a comonomer (acrylamide or methacrylamide) onto cotton fabrics to achieve enhanced durability to re‐chlorination. The poly(MAMPIP) grafted cotton, after chlorination, is highly effective against SARS‐CoV‐2 and achieves 4.59 log reduction (99.997%) after 5 min contact. Samples grafted with the copolymer of MAMPIP and acrylamide or methacrylamide are resistant to hydrolysis during re‐chlorination and retain high active chlorine and antiviral activity after 5 cycles of re‐chlorination (>3 log reduction after 10 min contact). Furthermore, the N‐chloramine coatings show excellent stability after exposure to simulated daylight conditions under an accelerated weathering tester, and storage for 200 days at 21 °C, 65% RH. The resulting quaternized N‐chloramine grafted cotton is a suitable platform for reusable antiviral textiles.
Osteogenic Differentiated Human Bone Marrow Stem Cells Contribute to Sprouting Angiogenesis Deceleration via Paracrine Excreted IGFBP7
Authors: Sun Shiyu , Cao Cen , Guo Yaru , Hou Yi , Meng Yanze , Li Yuman , Mei Feng , Hu Zhewen , Li Yao , Niu Yuting , Chen Yiming , Chen Lili , Huang Ying , Deng Xuliang 
Published: October 2022

AbstractDeceleration of sprouting angiogenesis until its final disappearance after blood vessel reconstruction is crucial for controlled tissue repair; however, its underlying mechanism remains unclear. It is reported that osteogenic differentiated bone marrow stem cells (OD‐BMSCs) contribute to sprouting angiogenesis deceleration by releasing intrinsic “OFF” signals. In vitro experiments show that insulin‐like growth factor‐binding protein 7 (IGFBP7) is the main component of OD‐BMSCs paracrine products which could inhibit the tube formation ability of endothelial cells. In addition, cell functional experiments show that IGFBP7 inhibits sprouting angiogenesis by reducing cell migration and tip cell specification. Furthermore, it is found that early IGFBP7 intervention, which accelerates sprouting angiogenesis deceleration during the early stage of healing, impedes bone defect healing. These results demonstrate that OD‐BMSCs could offer intrinsic inhibitory signals on sprouting angiogenesis and the appropriate emergence timing of these signals is crucial to maintain vasculature homeostasis during bone repairing. These results provide insight into the complex interaction between osteogenesis–angiogenesis coupling and suggest the potential therapeutic application of IGFBP7 in regulating vascular homeostasis.
Uniform π‐Conjugated‐Co‐Oligomer‐Based Nanofibers of Controlled Length with Near‐Infrared Emission, Photodynamic and Photothermal Activities
Authors: Ma Junyu , Hao Bingjie , Zhang Sen , Huang Xiaoyu , Lu Guolin , Feng Chun 
Published: October 2022

Abstractπ‐Conjugated‐polymer‐based nanofibers (CPNFs) have attracted considerable interest in the community of nanomedicine owing to their high‐aspect‐ratio architecture and inherent photo‐imaging, photothermal, photodynamic, and photoacoustic properties. However, the preparation of uniform CPNFs of controlled length and composition with near‐infrared emission (NIR), photothermal and photodynamic activity remains in its infancy. A novel block copolymer consisting of a donor‐acceptor‐donor (D‐A‐D) π‐conjugated co‐oligomer with a diketopyrrolopyrrole (DPP) unit as electron‐deficient acceptor flanked by oligo(p‐ phenylene ethynylene) (OPE) as an electron‐rich donor and a poly(2‐vinylpyridine) (P2VP) block (OPE4‐DPP‐OPE4‐b‐P2VP44, the subscripts describe the extra and average number of repeat units for π‐conjugated OPE segment and P2VP block, respectively) is designed and synthesized. By using the self‐seeding approach of living crystallization‐drive self‐assembly (CDSA), uniform CPNFs containing a D‐A‐D OPE4‐DPP‐OPE4 core and a P2VP corona with tunable length from 31 to 611 nm are generated. The resulting CPNFs exhibit NIR emission with a peak at 837 nm. The CPNFs also can serve as a photosensitizer to efficiently produce single oxygen and show a photothermal effect upon 660 nm irradiation. To the author's best knowledge, it is the first report on the generation of uniform CPNFs of controlled length with NIR emission, and photodynamic and photothermal activities by living CDSA.
Ni‐Doped CuO Nanoarrays Activate Urea Adsorption and Stabilizes Reaction Intermediates to Achieve High‐Performance Urea Oxidation Catalysts
Authors: Sun Hainan , Liu Jiapeng , Kim Hyunseung , Song Sanzhao , Fei Liangshuang , Hu Zhiwei , Lin Hong‐Ji , Chen Chien‐Te , Ciucci Francesco , Jung WooChul 
Published: October 2022

AbstractUrea oxidation reaction (UOR) with a low equilibrium potential offers a promising route to replace the oxygen evolution reaction for energy‐saving hydrogen generation. However, the overpotential of the UOR is still high due to the complicated 6e− transfer process and adsorption/desorption of intermediate products. Herein, utilizing a cation exchange strategy, Ni‐doped CuO nanoarrays grown on 3D Cu foam are synthesized. Notably, Ni‐CuO NAs/CF requires a low potential of 1.366 V versus a reversible hydrogen electrode to drive a current density of 100 mA cm−2, outperforming various benchmark electrocatalysts and maintaining robust stability in alkaline media. Theoretical and experimental studies reveal that Ni as the driving force center can effectively enhance the urea adsorption and stabilize CO*/NH* intermediates toward the UOR. These findings suggest a new direction for constructing nanostructures and modulating electronic structures, ultimately developing promising Cu‐based electrode catalysts.
Rhesus monkey sociality is stable across time and linked to variation in the initiation but not receipt of prosocial behavior
Authors: Talbot Catherine F. , Madrid Jesus E. , Del Rosso Laura A. , Capitanio John P. , Garner Joseph P. , Parker Karen J. 
Published: October 2022

AbstractRhesus monkeys and humans are highly social primates, yet both species exhibit pronounced variation in social functioning, spanning a spectrum of sociality. Naturally occurring low sociality in rhesus monkeys may be a promising construct by which to model social impairments relevant to human autism spectrum disorder (ASD), particularly if low sociality is found to be stable across time and associated with diminished social motivation. Thus, to better characterize variation in sociality and social communication profiles, we performed quantitative social behavior assessments on N = 95 male rhesus macaques (Macaca mulatta) housed in large, outdoor groups. In Study 1, we determined the social classification of our subjects by rank‐ordering their total frequency of nonsocial behavior. Monkeys with the greatest frequency of nonsocial behavior were classified as low‐social (n = 20) and monkeys with the lowest frequency of nonsocial behavior were classified as high‐social (n = 21). To assess group differences in social communication profiles, in Study 2, we quantified the rates of transient social communication signals, and whether these social signals were initiated by or directed towards the focal subject. Finally, in Study 3, we assessed the within‐individual stability of sociality in a subset of monkeys (n = 11 low‐social, n = 11 high‐social) two years following our initial observations. Nonsocial behavior frequency significantly correlated across the two timepoints (Studies 1 and 3). Likewise, low‐social versus high‐social classification accurately predicted classification two years later. Low‐social monkeys initiated less prosocial behavior than high‐social monkeys, but groups did not differ in receipt of prosocial behavior, nor did they differ in threat behavior. These findings indicate that sociality is a stable, trait‐like characteristic and that low sociality is linked to diminished initiation of prosocial behavior in rhesus macaques. This evidence also suggests that low sociality may be a useful construct for gaining mechanistic insight into the social motivational deficits often observed in people with ASD.
Size and degree of protection of native forest remnants drive the local occupancy of an endangered neotropical primate
Authors: Lins Poliana G. Alves de Souza , Ribeiro‐Júnior José W. , Peres Carlos A. , Penha Jerry 
Published: October 2022

AbstractAlthough the species–area relationship is well known, it may interact with and be augmented or cancelled out by other factors, such as local human disturbance. We used data on site occupancy of the Endangered blonde capuchin monkey (Sapajus flavius) based primarily on a standardized program of local interviews to model the influence of past human disturbance on the occurrence of this species across remaining forest patches of northeastern Brazil within the Atlantic Forest and Caatinga biomes. To do so, we assessed environmental covariates that best represent the history of human impacts. We then used single‐species occupancy models to assess site occupancy, while controlling for detection error during sampling. Surprisingly, we obtained a higher occupancy rate in the more arid Caatinga remnants than in the more mesic Atlantic Forest. Habitat patch size, history of site protection, and annual precipitation were the best predictors of local occupancy. Historical human disturbance, including subsistence hunting, has exerted considerable impact on the modern distribution of the blonde capuchin, whose geographic range largely spans a region historically lacking any wildlife protection. Matrix vegetation structure across the Caatinga, which so far has averted large‐scale mechanized agriculture, also creates a benign landscape that likely benefits contemporary capuchin occupancy. Local extinctions of this endangered primate will most likely continue unabated unless a ban on hunting in remaining Atlantic Forest and Caatinga fragments can be enforced.
Oligothiophene‐Ring‐Strapped Perylene Bisimides: Functionalizable Coaxial Donor–Acceptor Macrocycles
Authors: Dnyaneshwar Veer Sairam , Chandrakant Wakchaure Vivek , Asokan Kiran , Dixit Ruchi , Goswami Tanmay , Saha Ramchandra , Gonnade Rajesh , Ghosh Hirendra N. , Santhosh Babu Sukumaran 
Published: October 2022

AbstractAesthetic designs from nature enable new knowledge to be gained and, at the same time, inspire scientific models. In this context, multicomponent macrocycles embody the advantage of precisely positioning the structural units to achieve efficient communication between them. However, the construction of a functionalizable macrocycle for ultrafast charge separation and stabilization has not been attempted. Herein, we report the synthesis, crystal structure, and transient absorption of a new functionalizable macrocycle consisting of an oligothiophene‐ring‐strapped perylene bisimide. Transient absorption results point to a sequential improvement in charge separation and stabilization from the macrocycle to the corresponding linear dimer and 2D polymer due to the unique design. Our macrocycle design with a supportive spatial arrangement of the donor and acceptor units will inspire the development of more complex synthetic systems with exciting electron‐transfer and charge‐separation features.