bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent myocardial infarction: clinical, anamnestic and epidemiological aspects
Authors: Okrugin S. A. , Repin A. N. 
Published: October 2022

Highlights. Recurrent myocardial infarction remains an important health problem due to the high mortality of patients. At the same time, there is practically no data in the literature on the prevalence of this complication in the population, which makes studies carried out on the basis of long-term epidemiological programs relevant. The analysis of the “Acute Myocardial Infarction Register” (Tomsk) presented in the paper showed not only a high mortality rate of patients with recurrent infarction, but also a tendency to increase the incidence of this complication, which confirms the need to search for predictors of its occurrence.Aim. To determine the incidence of recurrent myocardial infarction (RMI) and mortality in patients with RMI in Tomsk for five years (2016–2020), to perform a clinical and anamnestic analysis of RMI episodes registered in 2019 and 2020.Methods. The study was performed on the basis of the data from the information and analytical database of the WHO program “Registry of Acute Myocardial Infarction”. In 2019–2020 1748 cases of acute myocardial infarction (AMI) were registered, in 1078 men (61.7%) and 670 women (38.3%). 87 patients with RMI were identified, which accounted for 5%. In this group, there were 46 men (52.9%) and 41 (47.1%) women. The age of RMI patients was almost identical (72.2±12.7 years old in men and 72.1±11.4 years old in women).Results. 51 (58.6%) patients were hospitalized with index AMI in a specialized department, 14 (16.1%) were treated in non-core hospitals and 22 (25.3%) people died at the prehospital stage. Patients with AMI with RMI and without RMI did not differ in clinical and anamnestic parameters. Coronary ventriculography was performed in 51 (58.6%) patients with RMI, in 41 (80.4%) cases there was a multivessel lesion of the coronary bed. RMI occurred in 43 (49.4%) patients who were treated in hospital, in 22 (25.3%) – at home, after discharge. RMI was detected in 22 (25.3%) of the dead at the prehospital stage. Typical and atypical clinical manifestations of RMI occurred in 53% and 47%, respectively. Stent thrombosis (24.1%) and the lack of treatment for indexAMI (35.6%) prevailed among the causes of RMI. It was not possible to establish the cause in 27.6% of cases. An increase in the incidence of RMI was noted from 2016 to 2020. During the follow-up, the mortality rate from RMI was two times higher than that among AMI patients in general.Conclusion. There were no significant clinical, anamnestic and other differences among patients with and without RMI. The established causes of RMI are not so much causes as a consequence of some factors. This fact, combined with the high mortality rate from RMI and the trend towards an increase in the incidence of RMI, makes it necessary to search for predictors of the onset of RMI and ways to prevent them.
Prognostic value of matrix metalloproteinases in patients with anthracycline-induced heart failure
Authors: Teplyakov A. T. , Shilov S. N. , Grakova E. V. , Kopeva K. V. , Bobyleva E. T. , Berezikova E. N. , Popova A. A. , Samsonova E. N. 
Published: October 2022

Highlights. Elevated levels of matrix metalloproteinases 2 and 9 are associated with the initiation and severity of CHF developed after breast cancer therapy with anthracyclines, which may contribute to cardiac remodeling and the progression of systolic dysfunction. Concentrations of matrix metalloproteinases-2 and -9 in blood serum serve as predictors of the unfavorable course of anthracycline-induced heart failure.Aim. To assess the role of matrix metalloproteinases-2 (MMP-2) and 9 (MMP-9) in the development and course of anthracycline-induced chronic heart failure (CHF) during 24 months of observation.Methods. The study included 114 women 12 months after completion of chemotherapy (CT) for breast cancer and developed CHF. The control group (n = 70) consisted of women (mean age 45.0 [42.0; 50.0] years old) who received doxorubicin as part of chemotherapy, but they did not develop CHF 12 months after completion of chemotherapy. The levels of biomarkers (MMP-2, MMP-9, NT-proBNP) in blood serum were determined using a sandwich immunoassay.Results. Patients with CHF had signs of cardiac remodeling and higher values of NT-proBNP, MMP-2 and MMP-9 (p<0.001) than women from the control group. After 24 months of observation, all patients with CHF were divided into 2 groups: group 1 – women with an unfavorable course of CHF (n = 54), group 2 – women with favorable course of pathology (n = 60). Criteria for the unfavorable course of CHF: the emergence of new or worsening of existing symptoms/signs of heart failure; and/or hospitalization due to HF decompensation; decrease in left ventricular ejection fraction by more than 10%; or an increase in the functional class of CHF by 1 or more. Baseline echocardiographic parameters and NT-proBNP values did not differ in groups 1 and 2. Levels of MMP-2 were higher by 8% (p = 0.017) and MMP-9 by 18.4% (p<0.001) in group 1. In 1 group the level of MMP-2 decreased after 24 months of observation. In group 2 the level of MMP-2 increased by the end of the observation period. MMP-2 levels ≥388.2 pg/ml (sensitivity 46%, specificity 80%; AUC = 0.64; p = 0.013) and MMP-9 ≥21.3 pg/ml (sensitivity 86%, specificity 84.4%; AUC = 0.9; p<0.001) were determined as predictors of an unfavorable course of CHF.Conclusion. Remodeling of the extracellular matrix may play an important role in the pathogenesis of CHF initiated by drugs of the anthracycline class. Elevated levels of MMP-2 and MMP-9 in the blood serum are associated with an unfavorable course of anthracycline-induced CHF and can be recommended when assessing the risk of an unfavorable course of pathology.
Blood monocytes in maintaining the balance of vascular endothelial injury and repair process in ischemic cardiomyopathy
Authors: Chumakova S. P. , Urazova O. I. , Denisenko O. A. , Pogonchenkova D. A. , Shipulin V. M. , Pryakhin A. S. , Nevskaya K. V. , Gladkovskaya M. V. 
Published: October 2022

Highlights. The features of subsets of monocytes in combination with the levels of desquamated endotheliocytes, endothelial damage and regeneration mediators and progenitor cell migration-enhancing factors in patients with coronary heart disease and with/without ischemic cardiomyopathy were analyzed. For the first time it was shown that in patients with ischemic cardiomyopathy, compared with CHD patients without cardiomyopathy, higher desquamation of the endothelium is associated with a deficiency of non-classical monocytes and reduced migration of progenitor endothelial cells (VEGFR2+-monocytes) with regenerative potential across the bone marrow due to a deficiency of the HIF-1α mediator in the blood.Background. The development of ischemic cardiomyopathy (ICM) is an understudied process, and one of its elements may be insufficient regeneration of blood vessels due to an imbalance of subsets of monocytes in the blood.Aim. To assess subsets of monocytes and desquamated endothelial cells in combination with endothelial damage and regeneration mediators in the blood of patients with coronary heart disease (CHD) and with/without ICM.Methods. The study included 30 patients with ICM, 22 patients with coronary heart disease without cardiomyopathy aged 55–69 years, and 18 healthy donors. In whole blood, the populations of CD45–CD146+ desquamated endothelial cells and progenitor endothelial cells related to CD14+VEGFR2+ monocytes, intermediate CD14++CD16+ and non-classical CD14+CD16++ monocytes were assessed by flow cytometry using the appropriate monoclonal antibodies (BD Biosciens, USA). In blood plasma, the levels of hypoxia-inducible factor HIF-1α, monocyte chemoattractant protein MCP-1 and matrix metalloproteinase MMP-9 were assessed by enzyme immunoassay. The results of the analysis were considered significant at p<0.05.Results. The number of progenitor and desquamated endothelial cells was increased in both groups of patients with coronary artery disease. At the same time, in patients with ICM, the number of progenitor endothelial cells did not reach the number noted in patients with CHD without cardiomyopathy, while the number of desquamated endothelial cells reached the number noted in CHD patients without cardiomyopathy. There was a deficiency of non-classical monocytes and HIF-1α in the blood of patients with ICM, and an excess of intermediate monocytes and MCP-1 was observed in CHD patients without cardiomyopathy. The concentration of MMP-9 in patients with CHD corresponded to the norm, regardless of the presence of ICM.Conclusion. In ICM, in contrast to CHD without cardiomyopathy, vascular damage is associated with a deficiency of nonclassical monocytes and reduced endothelial repair due to insufficient migration of progenitor endothelial cells across the bone marrow due to HIF-1α deficiency in the blood.
A Method to Generate Initial Fault Stresses for Physics-Based Ground-Motion Prediction Consistent with Regional Seismicity
Authors: Oral Elif , Ampuero Jean Paul , Ruiz Javier , Asimaki Domniki 
Published: October 2022

ABSTRACTNear-field ground motion is the major blind spot of seismic hazard studies, mainly because of the challenges in accounting for source effects. Initial stress heterogeneity is an important component of physics-based approaches to ground-motion prediction that represents source effects through dynamic earthquake rupture modeling. We hypothesize that stress heterogeneity on a fault primarily originates from past background seismicity. We develop a new method to generate stochastic stress distributions as a superposition of residual stresses left by the previous ruptures that are consistent with regional distributions of earthquake size and hypocentral depth. We validate our method on Mw 7 earthquake models suitable for California by obtaining a satisfactory agreement with empirical earthquake scaling laws and ground-motion prediction equations. To avoid the excessive seismic radiation produced by dynamic models with abrupt arrest at preset rupture borders, we achieve spontaneous rupture arrest by incorporating a growth of fracture energy as a function of hypocentral distance. Our analyses of rupture and ground motion reveal particular signatures of the initial stress heterogeneity: rupture can locally propagate at supershear speed near the highly stressed areas; the position of high-stress and low-stress areas due to initial stress heterogeneity determines how the peak ground-motion amplitudes and polarization spatially vary along the fault, as low-stress areas slow down the rupture and decrease stress drop. We also find that the medium stratification in the fault zone amplifies fault slip and consequent ground motion, which requires understanding the interaction between site effects and rupture dynamics. Our approach advances our understanding of the relations between dynamic features of earthquake ruptures and the statistics of regional seismicity, and our capability to integrate information about regional seismicity into near-field ground-motion prediction.
Pengembangan Media Pembelajaran Pencak Silat Berbasis Aplikasi Android Materi Variasi dan Kombinasi Untuk Siswa Kelas IX SMP Tahfidz Al-Manshurin Kabupaten Malang
Authors: Rosyidi Ali , Heynoek Febrita Paulina , Kurniawan Ari Wibowo , Hariyanto Eko 
Published: October 2022

Abstract: Media is one of the factors to encourage students to more easily understand the material in learning activities at school, so that media is needed in learning activities of pencak silat. The purpose of this research is to develop learning media of pencak silat based on android application for learning PJOK for grade 9 students of SMP Tahfidz Al-Manshurin Malang Regency which can be used as a learning medium for students both during school and at home learning and as a means of supporting teachers in providing pencak silat learning. The research method that the writer uses is descriptive quantitative method. Based on the results of the research taken, it shows that the average test carried out by filling out a questionnaire at SMP Tahfidz Al-Manshurin Malang City District is based on 85 percent of students who express more interest in learning pencak silat using Android application-based learning media, and 79 percent of students are more easy to learn in learning in the form of a series of pencak silat movements and balanced game activities. From the results of the analysis of all media variables obtained 79.7 percent it can be concluded that the learning media is in the "good" category or classification, and can be used in SMP Tahfidz Al-Manshurin Malang District.
Abstrak: Media merupakan salah satu faktor untuk mendorong Siswa lebih mudah memahami materi dalam kegiatan pembelajaran di sekolah, sehingga media sangat dibutuhkan dalam kegiatan pembelajaran pencak silat. Tujuan penelitian ini untuk mengembangkan media pembelajaran pencak menggunakan aplikasi android untuk pembelajaran PJOK siswa kelas 9 SMP Tahfidz Al-Manshurin Kabupaten Malang yang dapat dimanfaatkan sebagai media belajar bagi siswa baik saat pembelajaran di sekolah maupun di rumah dan menjadi sarana pendukung guru dalam memberikan pembelajaran pencak silat. Adapun metode penelitian yang digunakan penulis berupa metode deskriptif kuantitatif. Berdasarkan hasil penelitian yang diambil, menunjukkan bahwa rata-rata tes yang dilakukan dengan melakukan pengisian angket di SMP Tahfidz Al-Manshurin Kabupaten Kota Malang berdasarkan 85 persen siswa yang menyatakan lebih tertarik belajar pencak silat menggunakan media pembelajaran berbasis aplikasi android, serta 79 persen siswa lebih mudah belajar dalam pembelajaran menggunakan rangkaian gerak pencak silat dan diimbangi aktivitas bermain. Dari hasil analisis semua variabel media memperoleh 79,7 persen dapat disimpulkan bahwa media pembelajaran berada dalam kategori atau klasifikasi “baik”, dan dapat digunakan di SMP Tahfidz Al-Manshurin Kabupaten Malang.
Pengetahuan dan Subjective Norm untuk Perilaku Seksual Pekerja Usia Muda Kawasan Industri X
Authors: Fatmala Yuliana , Supriyadi Supriyadi , Deniati Ema Novita , Katmawanti Septa 
Published: October 2022

Abstract: Adolescence is a time when teenagers looking for an identity and their life. At this time, teenagers tend have a great curiosity about various things, include a sexual behavior. Sexual behavior at a young age in each individual is different. This sexual behavior was influenced by knowledge and subjective norms. The aims of this research were (1) to see there is an influence of knowledge on sexual behavior in young workers, (2) to see there is an influence of subjective norms on sexual behavior in young workers, and (3) to see there is a simultaneous effect between knowledge and subjective norms on sexual behavior in young workers. The method of this research used was a quantitative method with an explanatory research approach. This research sample’s used were 322 respondents with a significance level of 5 percent. The data collection technique used was a questionnaire. The results shows were (1) the knowledge aspect has a t-test value of 8.2124 which indicates an influence of knowledge on sexual behavior, (2) subjective norm has a t-test value of 7.540 which indicates an influence of subjective norms on sexual behavior, and (3) the test value f of 132,333 which indicated that knowledge and subjective norms had a simultaneous influence on sexual behavior.
Abstrak: Masa remaja merupakan masa dimana para remaja melakukan pencarian jati diri dan makna hidup. Remaja pada tahap ini cenderung sangat ingin tahu tentang berbagai hal, termasuk perilaku seksual. Perilaku seksual di usia muda pada setiap individu berbeda-beda. Perilaku seksual ini diantaranya dipengaruhi oleh pengetahuan dan subjective norm. Tujuan dari penelitian ini adalah (1) untuk melihat ada tidaknya pengaruh pengetahuan terhadap perilaku seksual pada pekerja usia muda, (2) untuk melihat ada tidaknya pengaruh subjective norm terhadap perilaku seksual pada pekerja usia muda, dan (3) untuk melihat ada tidaknya pengaruh secara simultan antara pengetahuan dan subjective norm terhadap perilaku seksual pada pekerja usia muda. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan pendekatan explanatory research. Sampel yang digunakan sebanyak 322 orang dengan taraf signifikansi 5 percent. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah kuesioner. Hasil penelitian menunjukkan (1) aspek pengetahuan mempunyai nilai uji t sebesar 8.2124 yang menunjukkan adanya pengaruh pengetahuan terhadap perilaku seksual, (2) subjective norm mempunyai nilai uji t sebesar 7.540 yang menunjukkan adanya pengaruh subjective norm terhadap perilaku seksual, dan (3) nilai uji f sebesar 132.333 yang menunjukkan bahwa pengetahuan dan subjective norm memberikan pengaruh secara simultan terhadap perilaku seksual.
Pembelajaran Daring PJOK di MTsN 2 Kota Malang
Authors: Armidianta Hafidh Praga , Winarno Mashuri Eko , Wiguno Lokananta Teguh Hari , Nurrochmah Siti 
Published: October 2022

Abstract: The formulation of the research problem is whether students at MTsN 2 Malang City are able to implement the PJOK learning model through online. This research is a quantitative descriptive study using a survey method, with a total sample of 98 students at MTsN 2 Malang City. The instrument used is in the form of a questionnaire or questionnaire that has been validated by the supervisor. Analysis of research data using descriptive statistical analysis method. The research results show that (1) the readiness of the institution 79 percent, good category. (2) organizational dimensions 78 percent, good category. (3) learning materials 80 percent, good category. The average number that gets a percentage value is 79 percent and if it is classified it is in the good category. The conclusion is that the implementation PJOK learning model at MTsN 2 Malang City through online learning has implemented learning that can help students and students in teaching and learning activities for PJOK learning well.
Abstrak: Rumusan masalah dalam penelitian ini yaitu apakah siswa di MTsN 2 Kota Malang mampu melaksanakan model pembelajaran PJOK melalui daring. Jenis penelitian adalah deskriptif kuantitatif menggunakan metode survei, dengan jumlah sampel sebanyak 98 siswa di MTsN 2 Kota Malang. Instrumen yang digunakan berbentuk angket atau kuesioner yang telah divalidasi oleh pembimbing. Analisis data penelitian menggunakan metode analisis statistik deskriptif. Hasil riset memaparkan bahwa (1) kesiapan lembaga sebesar 79 persen, dalam kategori baik. (2) dimensi organisasi 78 persen, dalam kategori baik. (3) materi pembelajaran sebesar 80 persen, dalam kategori baik. Jumlah rata-rata dari keseluruhan riset didapatkan nilai persentase sebesar 79 persen dan jika diklasifikasikan maka termasuk dalam kategori baik. Dapat disimpulkan bahwa model pembelajaran PJOK di MTsN 2 Kota Malang melalui pembelajaran daring telah menerapkan pembelajaran yang dapat membantu para siswa dan siswi dalam kegiatan belajar mengajar pembelajaran PJOK dengan baik.
Speaking of Online Learning: Alternative Practice-Based Learning Experiences for Speech Pathologists in Australia, Ghana and Hong Kong
Authors: Skeat Jemma , Bampoe Josephine Ohenewa , Booth Susan , Brogan Emily , Conway Maya , Davenport Rachel , Howells Simone , Kan Peggy , Krahe Michelle , Hewat Sally , Lewis Abigail , Little Alex , Walters Joanne , Webb Gwendalyn , Worthington Nikki 
Published: October 2022

Speech Pathology programs usually send students to workplaces to learn clinical skills necessary for practice. During COVID-19, programs needed to respond quickly to ensure that students continued to gain the necessary experiences and skills required to progress through their program and graduate as clinicians, while simultaneously complying with COVID-19 requirements. Case studies from seven different universities in Australia, Ghana and Hong Kong described the diverse ways in which placements were adapted to be COVID-safe, taking into account local needs. Some practices which had been included in placement education prior to the pandemic, such as telepractice and simulation-based learning, were extended and developed during this time. Educators, students, clinicians and clients responded to the rapidly changing needs of the time with flexibility and innovation, utilising a variety of technologies and tools to support case-based and virtual learning opportunities. Feedback from these diverse stakeholders about the experiences was positive, despite inevitable limitations and less-than-ideal circumstances. The positive findings provided insights for consideration in the future: could strategies implemented in response to the pandemic continue to be incorporated into placement experiences, enhancing current practices and maintaining student performance outcomes? Exceptional circumstances prompted exceptional responses; flexibility and innovation were accelerated in response to the pandemic and may transform future placement-based learning opportunities.
Constructivist pedagogy in E-learning: Solving problems of interaction with a student
Authors: Berestova Anna , Anisimova Tatyana , Morugina Olga , Lobuteva Liudmila , Lobuteva Alisa 
Published: October 2022

The study focuses on improving e-learning effectiveness and its implementation during the COVID-19-induced lockdown. The study involved 328 students aged 20 to 24 years with an equal number of males and females. Research shows that e-learning is mostly used together with embedded pedagogical tools and technologies rather than single training programs to improve the quality of teaching based on a unified method. Constructivism is an effective approach for this purpose. The research results can be used in programs with embedded learning elements based on constructivist pedagogy in online and blended learning at higher educational institutions.
Keywords: e-learning; constructivism; student-teacher interaction; problem-based learning; student-centered learning; individual learning path
COLOR BLIND PREVALENCE OF ELEMENTARY STUDENT IN SUMBERSARI SUBDISTRICT, JEMBER
Authors: Oktarianti Rike , Azizah Lutfia , Utami Eva Tyas 
Published: October 2022

Red-green color blindness is the most common type of color blindness. Color blindness disorders occur due to genetic factors determined by the recessive gene c (color blind) which is linked to the X chromosome. This study aims to determine the prevalence and frequency of color blind alleles and to determine the pattern of inheritance of color blind genes by conducting pedigree analysis on color blindness student’s family. The research was conducted in 13 public elementary schools, Sumbersari subdistrict, Jember Regency with a multistage cluster sampling method of sampling with a total sample of 286. Detection of color blindness using Ishihara's methods. Based on the results of this study, the color blindness prevalence of elementary school students in Sumbersari subdistrict, Jember was 2.79% with the prevalence in males and female were respectively as 4.86% and 0.7%. The allele frequency of color blindness was 0.021 and the normal allele frequency was 0.979. The pedigree analysis of a color blind student family shows the gene of color blindness is inherited in a criss-cross inheritance pattern.