bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative study on the adsorption characteristics of a triazine‐Si hybrid polymer adsorbent and the natural adsorbents for removal of methylene blue from industrial wastewaters
Authors: Zargoosh Kiomars , Ashrafzade Sheida , Afshari Mohaddeseh , Dinari Mohammad , Moradi Aliabadi Hossein 
Published: May 2022

AbstractThis work aims to compare the practical ability of the novel triazine‐based polymer adsorbents (TBPA‐Si hybrid polymer) with those of the natural adsorbents for the adsorption of methylene blue (MB) from the industrial wastewaters. In this regard, a new TBPA‐Si hybrid polymer includes SH, NH, and aromatic ring functional groups for effective interactions with a wide range of organic pollutants was synthesized. In addition, pine leaves, soybean meal (SBM), and wheat bran were selected as representative of the well‐known natural adsorbents. The optimum pH values for natural adsorbents and TBPA‐Si for MB adsorption were 7 and 8, respectively. The optimum time for wheat bran and TBPA‐Si to reach the maximum MB adsorption was 15 min and for pine leaves and SBM was 5 min. The isotherm data for TBPA‐Si hybrid was well fitted to Langmuir isotherm. Pine leaves showed a mix of Langmuir and Temkin isotherms. In addition, SBM and wheat bran also showed Temkin isotherm. During the kinetics investigations, the pseudo‐second‐order kinetics models were observed for all adsorbents. The maximum adsorption capacities for TBPA‐Si and pine leaves were 15.3 and 32.1 mg.g−1, respectively. The empirical adsorption capacity for SBM and wheat brans were 71.6 and 38.3 mg.g−1, respectively. The key advantage of the TBPA‐Si is its ability for removing MB in the presence of high concentrations of electrolytes, where the removal efficiencies of the natural adsorbent were extremely reduced in these conditions. The main advantage of the natural adsorbents is their low cost for removal of MB from the effluents containing very low concentration of electrolytes.
Low cross‐linked polyimide aerogel with imidazole for CO2 adsorption
Authors: Gao Yangfeng , Dong Chao , Zhang Fan , Ma Hongwei , Li Yang 
Published: May 2022

AbstractIn this study, low cross‐linked mesoporous polyimide aerogels with imidazole were successfully synthesized by co‐polymerization method at room temperature from DMBZ, ABIA, PMDA, and TAB. This synthesis method is milder than previous that of porous material synthesis. The experimental results show that polyimide aerogel with imidazole is a mesoporous material. The thermal decomposition temperatures of obtained polyimide aerogels are all above 450°C, which exhibited outstanding thermal stability. The microscopic morphology varies with the ratio of DMBZ/ABIA monomers. The specific surface area of polyimide aerogel tends to increase first and then decrease with the increase of ABIA content. The largest specific surface area is 240.87 m2/g. However, polyimide aerogel with high specific surface area had not high CO2 adsorption. In contrast, the PAPI‐4 sample with smaller specific surface area had higher CO2 adsorption. The maximum CO2 adsorption capacity is 14.20 cm3/g, which is comparable to those of previously reported porous organic polymers. This suggests that polyimide aerogel can be used as an adsorbent material. The high CO2 adsorptions may be attributed to the abundance of nitrogen‐rich heteroatoms in the polyimide networks.
Coupled CFD‐DEM modeling to predict how EPS affects bacterial biofilm deformation, recovery and detachment under flow conditions
Authors: Xia Yuqing , Jayathilake Pahala G. , Li Bowen , Zuliani Paolo , Deehan David , Longyear Jennifer , Stoodley Paul , Chen Jinju 
Published: May 2022

AbstractThe deformation and detachment of bacterial biofilm are related to the structural and mechanical properties of the biofilm itself. Extracellular polymeric substances (EPS) play an important role on keeping the mechanical stability of biofilms. The understanding of biofilm mechanics and detachment can help to reveal biofilm survival mechanisms under fluid shear and provide insight about what flows might be needed to remove biofilm in a cleaning cycle or for a ship to remove biofilms. However, how the EPS may affect biofilm mechanics and its deformation in flow conditions remains elusive. To address this, a coupled computational fluid dynamic– discrete element method (CFD‐DEM) model was developed. The mechanisms of biofilm detachment, such as erosion and sloughing have been revealed by imposing hydrodynamic fluid flow at different velocities and loading rates. The model, which also allows adjustment of the proportion of different functional groups of microorganisms in the biofilm, enables the study of the contribution of EPS toward biofilm resistance to fluid shear stress. Furthermore, the stress–strain curves during biofilm deformation have been captured by loading and unloading fluid shear stress to study the viscoelastic properties of the biofilm. Our predicted emergent viscoelastic properties of biofilms were consistent with relevant experimental measurements.
Tolerability and efficacy of durvalumab, either as monotherapy or in combination with tremelimumab, in patients from Asia with advanced biliary tract, esophageal, or head‐and‐neck cancer
Authors: Doki Yuichiro , Ueno Makoto , Hsu Chih‐Hung , Oh Do‐Youn , Park Keunchil , Yamamoto Noboru , Ioka Tatsuya , Hara Hiroki , Hayama Manabu , Nii Masahiro , Komuro Keiko , Sugimoto Mariko , Tahara Makoto 
Published: May 2022

AbstractBackgroundAgents targeting the programmed cell death‐1 pathway have demonstrated encouraging activity across multiple solid tumor types. The dose expansion phase of this phase I study evaluated the safety, tolerability, and antitumor activity of durvalumab monotherapy, and durvalumab plus tremelimumab (an anti‐cytotoxic T‐lymphocyte‐associated antigen 4 monoclonal antibody) combination therapy, in patients from Asia with biliary tract cancer (BTC), esophageal squamous cell carcinoma (ESCC), or head and neck squamous cell carcinoma (HNSCC).MethodsPatients with advanced BTC, ESCC, or HNSCC with disease progression during or following ≥1 platinum‐based therapy received durvalumab monotherapy (10 mg/kg every 2 weeks) or durvalumab plus tremelimumab (durvalumab 20 mg/kg every 4 weeks [Q4W] plus tremelimumab 1 mg/kg Q4W for 4 doses, followed by durvalumab 20 mg/kg Q4W). The primary objective was safety and tolerability. Secondary objectives included antitumor activity.ResultsDurvalumab monotherapy was assessed in 116 patients (median age 63.5 years, 75.9% male) of whom, 42, 42, and 32 had BTC, ESCC, or HNSCC, respectively. Grade ≥3 treatment‐related adverse events (TRAEs) were reported in 19.0%, 9.5%, and 25.0% of patients with BTC, ESCC, and HNSCC, respectively. Objective response rate (ORR) was 4.8%, 7.1%, and 9.4% in BTC, ESCC, and HNSCC. Durvalumab plus tremelimumab was evaluated in 124 patients (median age 62.0 years, 79.8% male) of whom 65 had BTC and 59 had ESCC. Grade ≥3 TRAEs were reported in 23.1% and 13.6% of patients with BTC and ESCC. ORR was 10.8% and 20.3% in BTC and ESCC. There were two complete responses and 10 partial responses in ESCC, and seven partial responses in BTC.ConclusionIn general, durvalumab monotherapy and durvalumab plus tremelimumab combination therapy displayed acceptable safety profiles consistent with published literature, and also demonstrated clinical benefit, in patients from Asia with BTC, ESCC, or HNSCC with disease progression on ≥1 prior treatment. ClinicalTrials.gov Identifier: NCT01938612.
Co‐Binding of JQ1 and Venetoclax Exhibited Synergetic Inhibitory Effect for Cancer Therapy; Potential Line of Treatment for the Waldenström Macroglobulinemia Lymphoma
Authors: Elamin Ghazi , Aljoundi Aimen , Soliman Mahmoud E. S. 
Published: May 2022

AbstractIn recent times, the development of combination therapy has been a focal point in drug discovery. This article explores the potential synergistic effect of co‐administration of Bcl2 inhibitor Venetoclax and BET inhibitor JQ1. We envisioned that the ‘dual‐site’‐binding of Bcl2 has significant prospects and paves the way for the next round of rational design of potent Waldenström macroglobulinemia (WM) therapy. The preferential binding mechanisms of the multi‐catalytic sites of the Bcl2 enzyme have been a subject of debate in the literature. This study conducted a systematic procedure to explore the preferred binding modes and the structural effects of co‐binding at each catalytic active site. Interestingly, a mutual enhanced binding effect was observed – Venetoclax increased the binding affinity of JQ1 by 11.5 %, while JQ1 boosted the binding affinity of Venetoclax by 16.3 % when compared with individual inhibition of each drug. This synergistic binding effect has significantly increased protein stability, with substantial correlated movements and multiple van der Waals interactions. The structural and thermodynamic insights unveiled in this report would assist the future design of improved combined therapy against WM.
Cerebral protection during percutaneous intervention for left ventricular assist device outflow graft obstruction
Authors: Joury Abdulaziz , Patel Rajan A. G. , Wever‐Pinzon James , Eiswirth Clement , Desai Sapna , Bansal Aditya , Krim Selim R. 
Published: May 2022

AbstractBackgroundLeft ventricular assist devices (LVAD) outflow graft obstruction is an uncommon complication but carries significant morbidity and mortality. Here we provide a case series of patients with LVAD intrinsic outflow graft obstruction who are deemed to be a high surgical risk for pump exchange and, therefore, underwent percutaneous intervention with the concomitant use of neuroprotective device—Sentinel cerebral protection system (CPS) (Boston Scientific) to prevent embolic stroke.MethodsWe retrospectively analyzed patients who underwent LVAD placement in our institution and developed LVAD outflow graft obstruction. The diagnosis of LVAD outflow graft obstruction was confirmed by utilizing various cardiac imaging modalities such as echocardiography and/or computed tomography angiography. All patients were treated with percutaneous intervention and a catheter‐based CPS.ResultsFrom a total of 501 LVAD implants in our institute, 6 (1.2%) patients with LVAD outflow graft obstruction who underwent percutaneous treatment were included; 4 patients with HeartMate‐III LVAD, 1 patient with HeartMate‐II LVAD, and 1 patient with HeartWare (HVAD). The median age of patients was 56.5 years at the time of LVAD implantation. The median time from the LVAD implantation to the episode of LVAD outflow obstruction was 1343 days. Utilization of Sentinel CPS resulted in the capture and removal of thrombus/debris in all patients.ConclusionsPercutaneous intervention of LVAD outflow graft obstruction is less invasive than surgical pump exchange and an acceptable alternative in properly selected patients. In our experience, utilization of a catheter‐based CPS can help in reducing the incidence of periprocedural embolic events.
Intramolecular (4+3) Cycloadditions of Oxidopyridinium Ions: Towards Daphnicyclidin A
Authors: Tu Jianzhuo , Ripa Rawshan A. , Kelley Steven P. , Harmata Michael 
Published: May 2022

AbstractN‐alkylation of 5‐hydroxynicotinic acid esters with electrophiles containing diene functionality produces salts that undergo intramolecular (4+3) cycloaddition reactions upon heating in the presence of base. Initial studies used a three‐carbon tether to join the pyridinium ion and diene, revealing some aspects of the inherent selectivity of the reaction with such substrates. Much more challenging was the synthesis of related species possessing only a two‐carbon tether. Nevertheless, the cycloaddition of such compounds was successful, leading directly to the ABC ring system of the alkaloid daphnicyclidin A.
Dipyrromethane‐Based PGeP Pincer Germyl Rhodium Complexes
Authors: Cabeza Javier A. , Fernández‐Colinas José M. , García‐Álvarez Joaquín , García‐Álvarez Pablo , Laglera‐Gándara Carlos J. , Ramos‐Martín Marina 
Published: May 2022

AbstractA family of germyl rhodium complexes derived from the PGeP germylene 2,2’‐bis(di‐isopropylphosphanylmethyl)‐5,5’‐dimethyldipyrromethane‐1,1’‐diylgermanium(II), Ge(pyrmPiPr2)2CMe2(1), has been prepared. Germylene1reacted readily with [RhCl(PPh3)3] and [RhCl(cod)(PPh3)] (cod=1,5‐cyclooctadiene) to give, in both cases, the PGeP‐pincer chloridogermyl rhodium(I) derivative [Rh{κ3P,Ge,P‐GeCl(pyrmPiPr2)2CMe2}(PPh3)] (2). Similarly, the reaction of1with [RhCl(cod)(MeCN)] afforded [Rh{κ3P,Ge,P‐GeCl(pyrmPiPr2)2CMe2}(MeCN)] (3). The methoxidogermyl and methylgermyl rhodium(I) complexes [Rh{κ3P,Ge,P‐GeR(pyrmPiPr2)2CMe2}(PPh3)] (R=OMe,4; Me,5) were prepared by treating complex2with LiOMe and LiMe, respectively. Complex5readily reacted with CO to give the carbonyl rhodium(I) derivative [Rh{κ3P,Ge,P‐GeR(pyrmPiPr2)2CMe2}(CO)] (6), with HCl, HSnPh3and Ph2S2rendering the pentacoordinate methylgermyl rhodium(III) complexes [RhHX{κ3P,Ge,P‐GeMe(pyrmPiPr2)2CMe2}] (X=Cl,7; SnPh3,8) and [Rh(SPh)2{κ3P,Ge,P‐GeMe(pyrmPiPr2)2CMe2}] (9), respectively, and with H2to give the hexacoordinate derivative [RhH2{κ3P,Ge,P‐GeMe(pyrmPiPr2)2CMe2}(PPh3)] (10). Complexes3and5are catalyst precursors for the hydroboration of styrene, 4‐vinyltoluene and 4‐vinylfluorobenzene with catecholborane under mild conditions.
Intra‐arterial chemoradiotherapy for locally advanced buccal mucosal cancer in an elderly patient with multiple comorbidities: A case report
Authors: Taniguchi Akito , Toyomasu Yutaka , Takada Akinori , Mase Takamitsu , Kurohara Kazuto , Omori Kazuki , Nanpei Yui , Kawamura Tomoko , Sakuma Hajime , Nomoto Yoshihito 
Published: May 2022

AbstractBackgroundThe management of locally advanced oral cavity squamous cell carcinoma (LA‐OCScc) in elderly patients with multiple comorbidities is difficult.CaseWe report the case of an elderly patient with buccal mucosal squamous cell carcinoma as well as chronic renal dysfunction, hepatic cirrhosis, rheumatoid arthritis, and metachronous diffuse large B‐cell lymphoma. We performed radiation therapy (a total dose of 70 Gy in 35 fractions) and six cycles of intra‐arterial chemotherapy with 40 mg/m2 cisplatin per week.After treatment, the tumor completely disappeared, and there was no recurrence or deterioration of comorbidities during the 12‐month follow‐up period.ConclusionIntra‐arterial chemoradiotherapy may be a good treatment option for LA‐OCScc in elderly patients with multiple comorbidities.
Hybridization Chain Reaction for mRNA Localization in Single Cells from Mouse and Human Cryosections
Authors: May‐Zhang Aaron A. , Benthal Joseph T. , Southard‐Smith E. Michelle 
Published: May 2022

AbstractIn situ hybridization has been a robust method for detection of mRNA expression in whole‐mount samples or tissue sections for more than 50 years. Recent technical advances for in situ hybridization have incorporated oligo‐based probes that attain greater tissue penetration and signal amplification steps with restricted localization for visualization of specific mRNAs within single cells. One such method is third‐generation in situ hybridization chain reaction (V3HCR). Here, we report an optimized protocol for V3HCR detection of gene expression using sectioned frozen tissues from mouse and human on microscope slides. Our methods and modifications for cryosectioning, tissue fixation, and processing over a three‐day V3HCR protocol are detailed along with recommendations for aliquoting and storing V3HCR single‐stranded DNA probes and hairpin amplifiers. In addition, we describe a method for blocking background signal from lipofuscin, a highly autofluorescent material that is widespread in human neurons and often complicates imaging efforts. After testing multiple strategies for reduction of lipofuscin, we determined that application of a lipofuscin quencher dye is compatible with V3HCR, in contrast to other methods like cupric sulfate quenching or Sudan Black B blocking that cause V3HCR signal loss. This adaptation enables application of V3HCR for in situ detection of gene expression in human neuronal populations that are otherwise problematic due to lipofuscin autofluorescence. © 2022 Wiley Periodicals LLC.Basic Protocol: Mouse and human fresh‐frozen tissue in situ hybridization chain reaction on microscope slidesSupport Protocol: Aliquoting of HCR probes and hairpins
Using SPAdes, AUGUSTUS, and BLAST in an Automated Pipeline for Clustering Homologous Exome Sequences
Authors: Ishengoma Edson , Rhode Clint 
Published: May 2022

AbstractCross‐species exome sequencing approaches provide unprecedented avenues for obtaining genetic diversity, evolutionary relationships, and functional information from a variety of organisms including non‐model species. These approaches offer cost‐effective opportunities to study multiple individuals or species in parallel, but also create bioinformatics challenges in the application of multiple but powerful bioinformatics tools for the identification of homologous gene families across individual or species boundaries. Popular tools of this kind include SPAdes for sequence assembly, AUGUSTUS for ab initio gene prediction, and BLAST for building homologous sequence families. These tools can also be sophisticated in terms of installation and usage. Here, we present detailed steps on how to run these tools for the recovery and clustering of exon sequences from cross‐species raw exome‐capture data into homologous sequence families. We also present a utility pipeline, CODSEQCP, that automates these steps to cluster exon sequences, facilitating population genomics and evolutionary studies. © 2022 Wiley Periodicals LLC.Basic Protocol 1: Reads assembly using SPAdesBasic Protocol 2: Coding sequence extraction using AUGUSTUSBasic Protocol 3: Sequence clustering using BLASTAlternate Protocol: How to run CODSEQCP
Isolation of Giant Viruses of Acanthamoeba castellanii
Authors: Machado Talita Bastos , de Aquino Isabella Luiza Martins , Abrahão Jônatas Santos 
Published: May 2022

AbstractThis article describes a practical method for prospecting and isolating giant viruses based on direct inoculation of environmental samples into amoeba cultures of Acanthamoeba castellanii. The giant viruses that infect amoebas have already been isolated from various environmental samples in several countries worldwide, including in extreme environments. Here we describe the methodologic procedures regarding the prospecting of giant viruses in A. castellanii, including the preparation of environmental samples, the culture of amoebas, and the observation of cytopathic effects that can indicate the presence and potential isolation of giant viruses. © 2022 Wiley Periodicals LLC.Basic Protocol 1: Sample collectionSupport Protocol: Propagation of Acanthamoeba castellaniiBasic Protocol 2: Prospecting of giant viruses in environmental samples by cytopathic effect analysis
Review of cool‐season turfgrass water use and requirements: II. Responses to drought stress
Authors: Braun Ross C. , Bremer Dale J. , Ebdon Jeffrey Scott , Fry Jack D. , Patton Aaron J. 
Published: May 2022

AbstractKnowledge of drought resistance of cool‐season turfgrasses is important because drought stress can occur wherever they are grown even in humid regions with wet climates. This review is Part II of two companion papers that review water use and requirements in cool‐season turfgrasses. Part I presented the history of early water conservation and quantification methods in turfgrass and then summarized research results since 1980 on cool‐season turfgrass evapotranspiration and deficit irrigation. Part II presents a brief history of drought research and then summarizes studies completed since 1980 on cool‐season turfgrass drought resistance including interspecies and intraspecies differences. This overview of research regarding drought resistance covers >30 field experiments that evaluated drought response to irrigation amounts, length of dry down, and the influence of environmental and management factors. More cool‐season turf research has focused on intraspecies variation in drought resistance of Kentucky bluegrass (Poa pratensis L.) or tall fescue (Festuca arundinacea Schreb.) than any other cool‐season turf species; therefore, more research is needed on other cool‐season turfgrass species, such as perennial ryegrass (Lolium perenne L.), bentgrasses (Agrostis L. ssp.), and fine fescues (Festuca L. spp.). Further study is warranted to investigate differences in drought resistance strategies among plants and management practices, shoot and root responses, subsequent recovery, and inter‐ and intraspecies variation in cool‐season turfgrasses especially in northern climatic regions where cool‐season turf species are adapted. Improvement of drought resistance in cool‐season turfgrasses will require focused breeding efforts with acute drought screening protocols.
How do customers' perceptions of corporate social responsibility contribute to sustainable customer citizenship behaviors? The mediating mechanisms of corporate brand pride and self‐brand connection
Authors: Jung Chang Mo , Hur Won‐Moo 
Published: May 2022

AbstractThis study extends previous research on corporate social responsibility (CSR) by including the mediating role of corporate brand pride and self‐brand connection from a relationship quality perspective. Based on the theoretical foundation of social identity theory, four hypotheses were established and tested using structural equation modeling. Data from 609 banking customers in Korea were collected via online questionnaire surveys. The results revealed the following: (1) Customers' perceptions of CSR are significant in enhancing customer citizenship behaviors. (2) Corporate brand pride mediates the positive relationship between customers' perceptions of CSR and customer citizenship behaviors. (3) Self‐brand connection mediates the positive relationship between customers' perceptions of CSR and customer citizenship behaviors. (4) Serial multiple mediation of corporate brand pride and self‐brand connection exist between customers' perceptions of CSR and customer citizenship behaviors. These results identified the mediating process related to the relationship quality between customers' perceptions of CSR and customer citizenship behavior.
Implementation of Izhikevich neuron based on stochastic computing using a novel inspired Omega‐Flip stochastic number generator
Authors: Hedayatpour Mohammad Ali , Karami Mohammad Azim , Shamsi Jafar 
Published: May 2022

AbstractThis paper presents an optimized stochastic multiplier to implement Izhikevich spiking neuron model. A novel stochastic number generator is used as the main block for stochastic computing to design a stochastic multiplier. The designed multiplier was used to describe and implement Izhikevich neuron model equation which is capable to produce variant responses of spiking neurons. To the best of the author's knowledge, this work is the pioneer using a designed multiplier for computing all of the multiplication expressions in spiking neuron equation. The effect of increasing number of bit streams on the accuracy of stochastic computing is studied. Furthermore, some numerical intervals that are more prone to the error are found and illustrated upon stochastic computing usage, and a method is proposed to improve the error prone numerical intervals. In addition, the response accuracy is optimized by changing time step parameter in solving ordinary differential Izhikevich neuron model equation using Euler's method. Hence, a 13‐bit stochastic multiplier is designed. It is found that variations in parameters a and b have a profound effect on the accuracy of recovery variable u and, consequently, on the responses. Out of 20 responses of Izhikevich neuron model, 11 responses are generated using the proposed stochastic computing method and compared with piecewise linear method and some previous architectures of Izhikevich neuron model implementations.