bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovering the Potential Value of Coenzyme Q10 in Oxidative Stress: Enlightenment From a Synthesis of Clinical Evidence Based on Various Population
Authors: Zhang Yili , Huang Xinyi , Liu Ning , Liu Mengmin , Sun Chuanrui , Qi Baoyu , Sun Kai , Wei Xu , Ma Yong , Zhu Liguo 
Published: July 2022

Background: Oxidative stress (OS) is associated with ferroptosis. Coenzyme Q10 (CoQ10), as an adjuvant treatment, has shown to be beneficial against OS. However, the efficacy of CoQ10 as a therapeutic agent against OS has not been promptly updated and systematically investigated.Methods: A systematic literature search was performed using the Medline, EMBASE, Web of science, Cochrane Central Register of Controlled Trials, CNKI, CBM, Science direct and clinical trial. gov to identify randomized clinical trials evaluating the efficacy of CoQ10 supplementation on OS parameters. Standard mean differences and 95% confidence intervals were calculated for net changes in OS parameters using a random-effects model.Results: Twenty-one randomized clinical studies met the eligibility criteria to be included in the meta-analysis. Overall, CoQ10 supplementation increased the levels of antioxidant enzymes [including superoxide dismutase (SOD) (SMD = 0.63; 95% CI: 0.38 to 0.88; p &lt; 0.001), catalase (CAT) (SMD = 0.44; 95% CI:0.16 to 0.72; p = 0.002)] significantly and the levels of malondialdehyde (MDA) (SMD = -0.68; 95% CI: 0.93 to -0.43; p &lt; 0.001) was decreased considerably. However, significant associations were not observed between this supplement and total antioxidant capacity (TAC), glutathione peroxidase (GPx) activity.Conclusion: CoQ10 can improve OS as indicated by statistical significance in CAT and MDA concentrations, as well as SOD activity. Future studies focusing on long-term results and specific valuation of OS parameters are required to confirm the efficacy of CoQ10 on OS. We also believe that with the further research on ferroptosis, CoQ10 will gain more attention.Systematic Review Registration: [https://inplasy.com/], identifier [INPLASY2021120123].
Effects of Feeding Fermented Medicago sativa (Plus Soybean and DDGS) on Growth Performance, Blood Profiles, Gut Health, and Carcass Characteristics of Lande (Meat) Geese
Authors: Li Hui , Liu Yang , Wei Lan , Lin Qian , Zhang Zhifei 
Published: July 2022

The objective was to investigate the effects of alfalfa (Medicago sativa Linn)-mixed silage fermentation material (AMSFM) on various aspects of growth, function, and carcass characteristics of Lande (meat) geese. Based on a previous study, we used the following AMSFM: 80% Alfalfa +10% soybean meal +10% DDGS ensiled for 45 days. Lande geese, n = 264, 77 days of age, were randomly allocated into four groups with six replicates in each group. Control geese were fed a basal diet, whereas experimental groups were fed a basal diet supplemented with 6, 12, or 24% AMSFM. The experiment lasted 21 days. The AMSFM promoted some aspects of growth, with increase (p &lt; 0.05) in leg muscle rate, lean meat rate, muscle protein content, and total energy content of leg muscle plus concurrent decreases (p &lt; 0.05) in crude fat content and abdominal fat rate in chest muscle. In addition, AMSFM increased (p &lt; 0.05) glutathione content in chest and leg muscles and serum superoxide dismutase activity, and it reduced (p &lt; 0.05) muscle malondialdehyde content and serum concentrations of triglycerides, total cholesterol, urea, and aspartate aminotransferase, consistent with good liver and kidney function. Moreover, AMSFM improved (p &lt; 0.05) ileum morphology. In conclusion, the optimal supplemented rate of AMSFM in the meat geese diet (12%) improved immunity and antioxidant status and enhanced growth performance and carcass characteristics of meat geese.
Effectiveness of Mental Health Warnings on Tobacco Packaging in People With and Without Common Mental Health Conditions: An Online Randomised Experiment
Authors: Sawyer Katherine , Burke Chloe , Ng Ronnie Long Yee , Freeman Tom P. , Adams Sally , Taylor Gemma 
Published: July 2022

BackgroundHealth warning labels on tobacco packaging are a cost-effective means of health risk communication. However, while an extensive range of physical health risks are well-portrayed via current tobacco health warnings in the UK, there are none that currently portray the negative impact of smoking on mental health.Aims(i) develop novel mental health warning labels for tobacco packaging and (ii) test perceptions of these warnings in smokers and non-smokers, with and without mental health problems.MethodsSix mental health warning labels were developed with a consultancy focus group. These warning labels were tested in an online randomised experiment, where respondents (N = 687) rated six Mental Health Warning Labels (MHWLs) and six Physical Health Warning Labels (PHWLs) on measures of perceived effectiveness, believability, arousal, valence, acceptability, reactance and novelty of information.ResultsMHWLs were perceived as low to moderately effective (mean = 4.02, SD = 2.40), but less effective than PHWLs (mean = 5.78, SD = 2.55, p &lt; 0.001, ηp2 = 0.63). MHWLs were perceived as less believable, arousing, unpleasant, and acceptable than PHWLs. MHWLs evoked more reactance and were rated as more novel. Perceptions of MHWLs did not differ in people with and without mental health problems except for reactance and acceptability, but consistent with the PHWL literature, perceptions of MHWLs differed between non-smokers and smokers.ConclusionMHWLs could be an effective means to communicate novel information about the effects of smoking on mental health. MHWLs are perceived as less effective, believable, arousing, unpleasant, and acceptable than PHWLs, but MHWLs evoke more reactance and are rated as more novel.
Associations Between Delivery Modes, Birth Outcomes and Offspring Anxiety Disorders in a Population-Based Birth Cohort of Children and Adolescents
Authors: Ståhlberg Tiia , Upadhyaya Subina , Polo-Kantola Päivi , Khanal Prakash , Luntamo Terhi , Hinkka-Yli-Salomäki Susanna , Sourander Andre 
Published: July 2022

ObjectiveMode of delivery and well-being markers for newborn infants have been associated with later psychiatric problems in children and adolescents. However, only few studies have examined the association between birth outcomes and anxiety disorders and the results have been contradictory.MethodsThis study was a Finnish population-based register study, which comprised 22,181 children and adolescents with anxiety disorders and 74,726 controls. Three national registers were used to collect the data on exposures, confounders and outcomes. Mode of delivery, the 1-min Apgar score, umbilical artery pH and neonatal monitoring were studied as exposure variables for anxiety disorders and for specific anxiety disorders. Conditional logistic regression was used to examine these associations.ResultsUnplanned and planned cesarean sections increased the odds for anxiety disorders in children and adolescents (adjusted OR 1.08, 95% CI 1.02–1.15 and aOR 1.12, 95% CI 1.05–1.19, respectively). After an additional adjustment for maternal diagnoses, unplanned cesarean sections remained statistically significant (aOR 1.11, 95% CI 1.04–1.18). For specific anxiety disorders, planned cesarean sections and the need for neonatal monitoring increased the odds for specific phobia (aOR 1.21, 95% CI 1.01–1.44 and aOR 1.28, 95% CI 1.07–1.52, respectively).ConclusionsBirth by cesarean section increased the odds for later anxiety disorders in children and adolescents and unplanned cesarean sections showed an independent association. Further studies are needed to examine the mechanisms behind these associations.
Is Brain-Derived Neurotropic Factor Methylation Involved in the Association Between Prenatal Stress and Maternal Postnatal Anxiety During the COVID-19 Pandemic?
Authors: Provenzi Livio , Villa Marco , Mambretti Fabiana , Citterio Andrea , Grumi Serena , Bertazzoli Emanuela , Biasucci Giacomo , Decembrino Lidia , Gardella Barbara , Giacchero Roberta , Magnani Maria Luisa , Nacinovich Renata , Pisoni Camilla , Prefumo Federico , Orcesi Simona , Scelsa Barbara , Giorda Roberto , Borgatti Renato 
Published: July 2022

BackgroundThe COVID-19 pandemic is a collective trauma that may expose susceptible individuals to high levels of stress. Pregnant women represent a high-risk population, considering that pregnancy is a period of heightened neuroplasticity and susceptibility to stress through epigenetic mechanisms. Previous studies showed that the methylation status of the BDNF gene is linked with prenatal stress exposure. The goals of this study were (a) to assess the association between pandemic-related stress and postnatal anxiety and (b) to investigate the potential role of maternal BDNF methylation as a significant mediator of this association.MethodsIn the present study, we report data on the association among pandemic-related stress during pregnancy, maternal BDNF methylation, and postnatal anxiety symptoms. Pandemic-related stress and postnatal anxiety were assessed through self-report instruments. BDNF methylation was estimated in 11 CpG sites in DNA from mothers’ buccal cells. Complete data were available from 108 mothers.ResultsResults showed that pandemic-related stress was associated with an increased risk of postnatal anxiety, r = 0.20, p &lt; 0.05. CpG-specific BDNF methylation was significantly associated with both prenatal pandemic-related stress, r = 0.21, p &lt; 0.05, and postnatal maternal anxious symptoms, r = 0.25, p = 0.01. Moreover, a complete mediation by the BDNF CpG6 methylation emerged between pandemic-related stress during pregnancy and postnatal maternal anxiety, ACME = 0.66, p &lt; 0.05.ConclusionThese findings suggest that BDNF epigenetic regulation by pandemic-related stress might contribute to increase the risk of anxiety in mothers. Policymakers should prioritize the promotion of health and wellbeing in pregnant women and mothers during the present healthcare emergency.
The Chilean Maternal-Infant Cohort Study-II in the COVID-19 Era: A Study Protocol
Authors: Mujica-Coopman María F. , Corvalán Camila , Flores Marcela , Garmendia María Luisa 
Published: July 2022

BackgroundPregnancy is a critical developmental window in which optimal maternal nutrition and health are key for pregnancy and infant development. The COVID-19 pandemic is considered as a “natural experiment” in which maternal and infant nutrition and health challenges were faced especially in developing countries. Therefore, understanding the health consequences for mothers and infants living in the COVID-19 era is key to revisit public health measures focused on maternal and infant health. The current work aims to describe the design, methods, and descriptive information at recruitment and preliminary findings of the Chilean Maternal &amp; Infant Cohort Study II (CHiMINCs-II) cohort.MethodsThe CHiMINCs-II is an ongoing cohort that is part of the Chilean Maternal and Infant Nutrition Observatory of the South-East area of Santiago, Chile. In total, 1954 pregnant women beneficiaries of the public health systems and their offspring were recruited before 15 weeks of gestation and are followed across pregnancy (&lt;15, 26–28, and 35–37 weeks of gestation) and up to 2 years of age in their offspring. Two studies are currently nested within the CHiMINCs-II cohort: (1) Breast Cancer Risk Assessment in Mothers (BRECAM) study, and (2) the CHiMINCs-COVID study. The primary objective of BRECAM study is to test the association between maternal metabolic indicators (i.e., insulin, glucose, insulin growth factor 1, and hemoglobin A1c concentrations) at early pregnancy (i.e., &lt;15 and 26–28 weeks of gestation) and breast density 3 months after the cessation of lactation. For this purpose, we collect maternal obstetric, lifestyle, dietary intake, anthropometric, and biochemical information. The aim of the CHiMINCs-COVID study is to assess maternal dietary intake and mental health problems derived from the COVID-19 pandemic and their association with maternal and infant's health and nutrition. Thus, we collected detailed information on dietary behaviors, mental health, and COVID-related information at each trimester, along with neonatal and infant nutritional information.DiscussionThe findings of this study will provide novel and critical information to better understand maternal nutritional status, mental health, as well as infant growth and nutrition during the COVID-19 era.Clinical Trial RegistrationBRECAM study registration number NCT03920098 and CHiMINCs-COVID study registration number NCT01916603.
Diagnosis and ECMO Treatment of a Critically Ill Patient With Disseminated Mycobacterium tuberculosis: A Case Report
Authors: Shang Xiuling , Zhang Hongxuan , Chen Sheng , Wang Chen , Lin Meifu , Yu Rongguo 
Published: July 2022

BackgroundMycobacterium tuberculosis infection remains a public health concern worldwide. The diagnosis and treatment of disseminated M. tuberculosis is very difficult, so we shared our experiences and lessons learned in this case report.Case PresentationA 36-year-old female with a history of epilepsy presented to our hospital with fever, upper abdominal pain, muscle soreness in limbs for 7 days, and shortness of breath for 4 days. On admission, she presented with acute respiratory distress syndrome (ARDS) and liver dysfunction. Due to the critical nature of her clinical presentation, the patient was admitted directly to the Intensive Care Unit (ICU), received mechanical ventilation in prone position and VV-ECMO treatment. Her condition improved gradually, and the ECMO was removed after 7 days and she was weaned off the ventilator after 8 days. However, her fever recurred and she underwent PET-CT examination, liver contrast ultrasound, acid-fast staining and second-generation sequencing of cerebrospinal fluid, which confirmed M. tuberculosis infection.ConclusionThis case report briefly described the treatment and diagnosis of a critically ill patient with intra and extra-pulmonary tuberculosis infection. Timely and appropriate treatment is crucial to save lives, but the timing of ECMO treatment needs to be carefully considered for patients with ARDS caused by tuberculosis.
The Covid-19 Pandemic and Maternal Mental Health: A Longitudinal Study of Chilean and Foreign-Born Mothers
Authors: Abufhele Alejandra , Narea Marigen , Telias Amanda 
Published: July 2022

Objectives: We explore the effects of the pandemic on stress, depressive symptoms and parenting practices of mothers with children aged between 24- and 30-months, residents in Santiago, Chile, and the differences between foreign‐born and native‐born mothers.Methods: Using data from the longitudinal project Mil Primeros Días and lagged-dependent models, we analyzed parental stress, depressive symptoms and parenting practices for native-born and foreign-born mothers. Lagged-dependent model allows us to take advantage of the longitudinal data by controlling for the previous score and baseline individual characteristics.Results: After 8 months of the pandemic, mothers of young children have more depressive symptoms, are more stressed, and show more hostility towards their children. Foreign-born mothers had 0.29 and 0.22 standard deviations (SD) more than native-born mothers in the parental distress and difficult child scales from the Parental Stress Index (PSI), respectively, and 0.17 SD more in the hostile-reactive parental behavior dimension.Conclusion: Findings suggest the need to implement policies and programs that prevent mental health deterioration for mothers, especially migrant mothers, to improve women’s psychological condition and child wellness.
Pandemic Clones of CTX-M-15 Producing Klebsiella pneumoniae ST15, ST147, and ST307 in Companion Parrots
Authors: Davies Yamê Miniero , Cunha Marcos Paulo Vieira , Dropa Milena , Lincopan Nilton , Gomes Vasco Túlio Moura , Moreno Luisa Zanoli , Sato Maria Inês Zanoli , Moreno Andrea Micke , Knöbl Terezinha 
Published: July 2022

Psittacine birds are commonly kept as companion birds and the maintenance of these birds in captivity may represent a zoonotic risk and contribute to the propagation of multidrug-resistant and β-lactamase extended-spectrum (ESBLs)-producing pathogens. This study aimed to identify and characterize strains of the Klebsiella pneumoniae complex isolated from diseased psittacine birds, determining virulence and resistance profiles. K. pneumoniae strains were isolated from 16 birds (16/46). All strains carried more than three virulence genes, with a high frequency of fimH and kpn (93.75%), uge (87.52%), and irp-2 (81.25%) genes. The antimicrobial susceptibility revealed that 3/16 strains were ESBL producers. Genomic analysis revealed that CTX-M-15-positive strains belonged to sequence types (STs) ST15, ST147, and ST307, characterized as international clones associated with outbreaks of healthcare-associated infections (HAIs) worldwide.
GPs’ interest in integrated care for frail older adults and corresponding consulting and prescribing data: qualitative and quantitative analyses of the PAERPA integrated care project
Authors: Calafiore Matthieu , Chazard Emmanuel , Averlant Lorette , Ramez Claire , Sarrazin Fanny , Leveque Nathalie , Dambre Delphine , Verloop David , Defebvre Marguerite-Marie , Di Martino Carla , Beuscart Jean-Baptiste 
Published: July 2022

BackgroundIntegrated care pathways can help to avoid unnecessary admissions to hospital and improve the overall quality of care for frail older patients. Although these integrated care pathways should be coordinated by GPs their level of commitment may vary.AimTo profile GPs who had participated or had declined to participate in the Personnes Agées En Risque de Perte d’Autonomie (PAERPA) integrated care project (ICP) in the Valenciennois-Quercitain area of France between 2014 and 2019.Design and settingA combined qualitative and quantitative analysis of GPs who were participating in or had declined to participate in the PAERPA ICP.MethodBoth GPs participating in the ICP and GPs who chose not to participate in the ICP were interviewed, and then consultation and prescription profiles for these two groups were compared.ResultsSome GPs were interested in the PAERPA ICP, whereas others were opposed. The 48 qualitative interviews revealed four issues that influenced participation in the PAERPA ICP: 1) awareness of issues in care of older adults and the value of collaborative work; 2) time saving; 3) task delegation; and 4) advantages of coordination. The level of interest in the ICP for frail older adults was indirectly reflected by the data on consulting and prescribing. In GPs who participated in the PAERPA ICP there was a greater proportion of older (aged ≥70 years) patients (P<0.05), a larger number of consultations per year (P<0.05), and a larger number of home visits (P<0.01), relative to GPs who declined to participate.ConclusionThe level of interest in the PAERPA ICP for frail older adults varied widely among GPs. These findings suggest that commitment to an integrated care pathway could be increased by customising the recruitment strategy as a function of the GP’s profile.
Analisis dan Desain Sistem Informasi Akuntansi Berbasis Web pada CV. Royal Mas Tripnusa
Authors: Yuliana Ni Komang Ary , Satwika I Putu , Redioka Anak Agung Ngurah 
Published: July 2022

<p>CV. Royal Mas Tripnusa still uses conventional applications in reporting and managing financial transactions, so the transaction reports are inaccurate with the actual financial situation of the company. This research conducts system analysis and design in developing accounting information systems, to help document company activities, make cost budgets, and help management performance become more effective and efficient. The system development method used in this research is the System Development Life Cycle (SDLC) by applying only two initial stages, namely system analysis and concept design. The result of application design are features in the form of a cash receipts and disbursement recommendation system, database design, system process design, and interface design that can be used to create sales invoices, view receipt reports, and view cash and sales disbursements.</p><p>Keywords: Analysis and Design, Accounting information system, internal control system, Webbased</p><p>ABSTRAK. CV. Royal Mas Tripnusa masih menggunakan aplikasi konvensional dalam melakukan pencatatan dan pengelolaan transaksi keuangan, sehingga laporan transaksi yang dihasilkan kurang akurat dengan keadaan keuangan perusahan yang sebenarnya. Penelitian ini melakukan analisis dan desain sistem dalam membuat sistem informasi akuntansi, untuk membantu mendokumentasi aktivitas perusahaan, pembuatan anggaran biaya, serta membantu kinerja manajemen menjadi lebih efektif dan efisien. Metode pengembangan sistem yang digunakan adalah Sistem Development Life Cycle (SDLC) dengan hanya menerapkan dua tahapan awal yaitu analisis sistem dan perancangan konsep. Rancangan aplikasi menghasilkan fitur-fitur berupa sistem rekomendasi penerimaan dan pengeluaran kas, rancangan database, rancangan proses sistem, serta rancangan antarmuka yang dapat digunakan untuk membuat faktur penjualan, melihat laporan penerimaan, dan melihat pengeluaran kas serta penjualan. <br /> Kata kunci: Analisis dan Desain, Sistem Informasi Akuntansi, Sistem Pengendalian Intern, Berbasis Web</p><p> </p>