bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical Thrombectomy in Acute Ischemic Stroke
Authors: Rajan Jayadevan E , Kannath Santhosh K , Sabarish Sekar , Arun K , P Varma P Ravi , Sreedharan Sapna E , Sukumaran Sajith , Sylaja PN 
Published: September 2022

Abstract

Background:
In patients with acute ischemic stroke with large vessel occlusion, various angiographic features are important in patient selection and predicting outcome.

Objective:
We evaluated angiographic features like collaterals, clot burden score, angiographic recanalization, number of passes, and intracranial atherosclerotic disease (ICAD) with the functional outcome at 90 days.

Materials and Methods:
This was a retrospective analysis of prospectively collected data of 163 patients with acute ischemic stroke with large vessel occlusion who underwent mechanical thrombectomy within 24 hours of symptom onset. Angiographic data were reviewed blinded to clinical data. The outcome was defined as modified Rankin scale (mRS) at 90 days (good outcome mRS ≤2)

Results:
The median age of patients was 60 years and 34.4% were females. The median National Institutes of Health Stroke Scale (NIHSS) and Alberta Stroke Programme Early CT Score (ASPECTS) at admission were 17 and 6, respectively. On bivariate analysis, ASPECTS was >6, clot burden score was ≥7, recanalization of TICI was ≥2b, absence of ICAD, showed a positive correlation with the good outcome at 90 days (P-values of 0.003, 0.0001, and 0.03, respectively). Multiple attempts of device passes were associated with poor recanalization (P = 0.001) and it was seen more in ICAD patients. On multivariate analysis, independent predictors of poor outcome were clot burden score <7 (P = 0.043) and TICI score <2b (P = 0.048). Out of 41 patients (26%) with ICAD, 29 had a poor outcome at 90 days.

Conclusion:
Lower clot burden and less degree of recanalization were associated with poor outcome in acute ischemic stroke due to Large vessel occlusion (LVO). The presence of ICAD also predicted poor outcome.
Postoperative Early Lumbar Drainage Can Reduce the Duration of Fever or Infection in Patients with Complicated Intracranial Tumors after a Long Operation Time
Authors: Wu Yingxi , Zhang Yunze , Wu Yang , Zhu Gang , Xue Yafei , Qu Yan , Zhao Tianzhi 
Published: September 2022

Abstract

Background:
Intracranial fever or infection is one of the common complications after craniotomy, especially for complicated intracranial tumors such as deep skull base tumors.

Objective:
We used early cerebrospinal fluid (CSF) drainage with a preplaced lumbar drainage (LD) tube after surgery and observed whether this procedure could reduce the rate and duration of fever or infection.

Material and Methods:
The authors conducted a retrospective study of 142 patients who underwent complicated intracranial tumor surgery with no less than four hours of dural opening at the Center of Neurosurgery of Tangdu Hospital. The LD group underwent preoperative LD placement, intraoperative CSF release and postoperative continuous drainage, but the control group received routine craniotomy without preoperative LD. The primary outcomes included the rate, duration, and hospital length of stay (LOS) for patients with fever or infection after surgery, as compared between the two groups. The second outcome included complications related to LD and the rate of postoperative CSF leakage.

Results:
There were 22 patients in the LD group and 23 patients in the control group who presented with delayed fever, which was supposed to be caused by intracranial infection or aseptic inflammation. The median duration of delayed fever in the LD group was obviously lower than that in the control group (7.762 ± 3.129 days vs 11.73 ± 5.239 days), and there was a statistically significant difference (P = 0.0046). In addition, there was a significant reduction in the median postoperative LOS (12 [8,10,15,21] days in the LD group vs 15 [9,13,20,28] days in the controls). Moreover, there was no significant difference in complications related to LD between the two groups. Three patients with brain herniation were observed in the LD group compared with one patient in the control group. All four patients had contemporary mild-to-moderate neurologic disorders after surgery or conservative treatment. Additionally, the rate of CSF leakage in the LD group was 5.41% (4/74), which was lower than that in the control group (8/68, [11.76%]), although there was no significant difference (P = 0.174).

Conclusions:
For patients receiving complicated intracranial lesions following a long operation time, postoperative early LD was beneficial for the treatment of patients with fever or infection. It not only reduced the duration of infection or fever in postoperative patients but also decreased the postoperative LOS. We should minimize the complications related to LD by careful and standardized LD and management processes, and ensure the effectiveness and safety of this treatment.
Using Multiple Logistic Regression to Determine Factors Affecting Delaying Hospital Arrival of Patients with Acute Ischemic Stroke
Authors: Amani Firouz , Fattahzadeh-Ardalani Ghasem , Sharghi Afshan , Jafarizadeh Raana 
Published: September 2022

Abstract

Background:
Early treatment of ischemic stroke patients who arrive at the hospital ≤4.5 hours after the onset of symptoms with recombinant tissue plasminogen activator is more beneficial and very important.

Objective:
This study is aimed to investigate the factors delaying the hospital arrival of patients with acute ischemic stroke by using multiple logistic regression analysis.

Methods and Materials:
This descriptive cross-sectional study was done on patients diagnosed with acute ischemic stroke who were referred to Ardabil city Training and Research hospital at 2018. All patients and/or patient relatives were interviewed and data were collected through a checklist including demographic and clinical data of patients to explore the involved factors delaying hospital arrival of patients and then analyzed using multiple logistic regression analysis.

Results:
Of all included patients, only 25.3% arrived at the hospital in ≤ 4.5 hours. By using multivariate logistic regression analysis, living in cities (P = 0.007), cigarette consumption (P = 0.032), having valvular heart disease (P = 0.008), and gender (P = 0.049) were factors associated with an early arrival to the hospital.

Conclusions:
Results showed that most of the patients had a considerable delay in arriving at the hospital in ≤ 4.5 hours. Thus, providing health promotion strategies to improve society awareness of early symptoms of stroke, training of local physicians about the importance of early arrival of stroke patients, and more extended ambulance services in all cities and rural areas are necessary for better management of acute stroke patients in this area.
FTY720 Attenuates Cerebral Vasospasm After Subarachnoid Hemorrhage Through the PI3K/AKT/eNOS and NF-κB Pathways in Rats
Authors: Kuai Feng , Zhou Jianping , Qiu Yuchen , Gao Yang 
Published: September 2022

Abstract
Cerebral vasospasm (CVS) is a major complication of subarachnoid hemorrhage (SAH). Inflammation and nitric oxide (NO) have become increasingly recognized as key pathogenic contributors to brain injury in this condition. We aimed to examine the role of FTY720 in CVS after SAH. Endovascular perforation was used to establish an SAH model. Seventy-five male Sprague–Dawley rats were randomly divided into five groups: sham, sham + FTY720, SAH + saline, and two SAH + FTY720 (0.5 and 1 mg/kg) groups. The results showed that FTY720 treatment in both the surgery and nonsurgery groups decreased the counts of leukocytes and lymphocytes 72 hours after SAH. TNF-α (tumor necrosis factor alpha) and IL-1β (interleukin 1 beta) in both the cerebrospinal fluid (CSF) and the hippocampus were decreased, and the NF-κB (nuclear factor kappa B) pathway was inhibited. The levels of apoptotic proteins were downregulated. FTY720 promoted NO generation by activating the PI3K/AKT/eNOS pathway. CVS and neurological deficits in the SAH rats were ameliorated after FTY720 treatment. Compared with the sham-only animals, FTY720 treatment in the nonsurgery group did not increase mortality. These results indicated that FTY720 could alleviate CVS due to its anti-inflammatory and antiapoptosis effects and the promotion of NO generation. FTY720 may be effective in the clinical treatment of SAH patients.
Determination of Predictors of Brain Injury in Very Preterm Infants – A Retrospective Cohort Study
Authors: Abiramalatha Thangaraj , Devi Usha , Nagaraj Suhas , Ramya Gurujala Mahadeva , Tangirala Susmitha , Chandrasekaran Ashok 
Published: September 2022

Abstract

Background:
Despite decades of research, there is inadequate evidence on the etiological factors of brain injury in preterm infants.

Objective:
To study the perinatal risk factors for preterm brain injury and to assess their strength of association.

Methods:
In this retrospective cohort study, we included infants born at <32 weeks' gestation and had either magnetic resonance imaging (MRI) or cranial ultrasound (CUS) performed at term equivalent age. Significant brain injury was diagnosed based on Kidokoro global brain injury score was ≥4 in MRI or cystic periventricular leukomalacia in CUS.

Results:
Among the 698 infants, 48 had significant brain injury and 650 were taken as controls. In multiple logistic regression, intraventricular hemorrhage (IVH) grade 3-4 [adjusted odds ratio, 92.892 (19.495-442.619)], culture-positive sepsis [4.162 (1.729-10.021)], prolonged ventilation [3.688 (1.087-12.510)], and small for gestational age (SGA) [2.645 (1.181-5.924] were associated with greater risk of preterm brain injury.

Conclusion:
Severe IVH, culture-positive sepsis, prolonged ventilation and SGA were significant risk factors for preterm brain injury with severe IVH being the most significant contributing factor.
”PTFE Sleeve Graft” Technique to Remove Neurovascular Conflict in Micro Vascular Decompression for Trigeminal Neuralgia
Authors: Sinha Ajit K. , Jain Shrey , Vyas Medha A. , Krishnankutty Muralikrishnan 
Published: September 2022

Abstract

Background:
Microvascular decompression (MVD) of the trigeminal nerve is a well-accepted nondestructive procedure for trigeminal neuralgia. Usually, Teflon (PTFE) puff or felt graft techniques, which are most commonly used, are associated with arachnoiditis and recurrence among other complications. We use the “sleeve graft” technique using PTFE to separate the neurovascular conflict and here we describe our experience with the same in 376 cases.

Objectives:
To study the outcomes in 376 patients treated with sleeve graft technique for trigeminal neuralgia.

Materials and Methods:
For a period of 18 years, from 2002 to 2020, all cases of medically refractory trigeminal neuralgia were subjected to the “sleeve graft” technique for MVD. Pre- and post-operatively, pain score was given according to Barrow Neurological Institute pain intensity score. Cases were observed for any complications and pain relief in short and long-term follow-up.

Results:
In total, 376 cases of refractory primary trigeminal neuralgia cases, among which 198 patients underwent MVD with no prior intervention, 158 underwent MVD following percutaneous ablative procedure, 13 were “Revision MVD” previously done at other centers, and four were post gamma knife failure. There was no incidence of arachnoiditis or recurrence of symptoms. Further, 368 (97.8%) patients had complete recovery from symptoms while eight (2.2%) had partial recovery after 5 years of follow-up. Complications included hearing loss (n = 1), temporary hypoesthesia (n = 45), and permanent hypoesthesia (n = 7).

Conclusion:
“PTFE Sleeve Graft” technique to remove the neurovascular conflict in micro vascular decompression (MVD) for trigeminal neuralgia is a safe and effective technique that yields better results.
Radiological Evaluation of Anatomical Extensions of Gliomas Based on White Fiber Tracts
Authors: Shah Abhidha , Vutha Ravikiran , Goel Atul 
Published: September 2022

Abstract

Background:
We speculate on the origin and extensions of gliomas based on our understanding of anatomy of the subcortical network, radiological evaluation and surgical experience.

Objective:
We recently classified the white fibers of the brain into four horizontal and one vertical group. The role of this classification in understanding the origin and spread of gliomas is analyzed.

Materials and Methods:
A series of 220 consecutive radiological images of patients with low and high grade gliomas were retrospectively evaluated. The classification discussed was applied to these images to study the location and direction of growth of the gliomas.

Results:
Our results identify that gliomas arise and spread along a named white fiber tract and displace the adjoining tracts. Gliomas that arose from arcuate fibres either remained limited to a gyrus or extended to the adjacent gyri along the course of the arcuate fibres. Gliomas arising from the LAF spread in the direction of the affected tract. Gliomas arising from the CF tended to involve both the hemispheres and extended across the midline.

Conclusion:
This radiological evaluation of gliomas correlated well with our proposed anatomical classification of white fibers. Gliomas probably originate in the fiber tract and grow along its extension. The adjoining fiber tracts form a reliable barrier to its spread. The surgical implication of the understanding is outlined in brief here and evaluated in details in part B of this study.
Effect of the Non-N-Methyl-D-aspartate Receptor of the Glutamatergic System of the Pedunculopontine Tegmental Nucleus on Cardiovascular Responses in Normotensive and Hydralazine-Induced Hypotensive Rats
Authors: Hosseiniravesh Mohammad Reza , Hojati Vida , Mohebbati Reza , Khajavirad Abolfazl , Shajiee Hooman , Shafei Mohammad Naser 
Published: September 2022

Background:
Glutamate is an important excitatory neurotransmitter in the pedunculopontine tegmental (PPT) nucleus. The cardiovascular effect of glutamate and its non-N-methyl-D-aspartate (NMDA) receptor in the PPT is unknown; therefore, we evaluated glutamate and its non-NMDA receptor on cardiovascular parameters in normotensive and hypotensive induced by hydralazine (HLZ) in rat.

Materials and Methods:
After anesthesia, the femoral artery was cannulated for recording of cardiovascular parameters. Microinjection of drugs was done stereotaxically. L-Glutamate (L-Glu) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) (an antagonist of nonNMDA receptor) were microinjected into the PPT in normotensive and HLZ hypotensive rats. Changes (Δ) of mean arterial pressure (MAP), systolic blood pressure (SBP), and heart rate (HR) were obtained and compared with the control group.

Results:
In normotensive rats, L-Glu significantly increased SBP and MAP (P < 0.001) and decreased HR (P < 0.01), whereas CNQX alone did not significantly effect. Coinjection L-Glu + CNQX significantly attenuates the cardiovascular effect of L-Glu (P < 0.05 to P < 0.01). In hypotension induced by HLZ, SBP and MAP significantly decrease but HR did not change. In HLZ groups, L-Glu significantly improves (P < 0.05) and CNQX deteriorated hypotension induced by HLZ (P < 0.05). Coinjection of L-Glu + CNQX also attenuates the effect of L-Glu on Δ MAP and Δ SBP. In hypotension, ΔHR induced by L-Glu was significantly higher than CNQX (P < 0.01). In L-Glu + CNQX group, ΔHR also was lower than L-Glu (P < 0.05).

Conclusion:
Our findings revealed that glutamatergic system of the PPT in both normotensive and hypotension induced by HLZ plays a pressor with bradycardic responses that partly mediated by non-NMDA receptor.
EPIYA Motif Genetic Characterization from Helicobacter pylori Isolates in Distinct Geographical Regions of Iran
Authors: Estaji Fatemeh , Nasr Esfahani Bahram , Zibaee Saeed , Sanei Mohammad Hossein , Moghim Sharareh 
Published: September 2022

Background:
This study aimed to determine the current EPIYA motifs of the cagA gene in Helicobacter pylori isolates from patients with gastric disorders, and evaluate the association between these patterns and the clinical outcome of H. pylori infection in different geographical regions of Iran.

Materials and Methods:
We examined 150 patients with gastrointestinal disorders from the central and eastern regions of Iran. The detection of H. pylori and screening of cagA was performed by polymerase chain reaction (PCR). The pattern of the motifs was determined by PCR followed by sequencing.

Results:
The overall prevalence of H. pylori was 66.3% in eastern (Mashad) and 50.6% in the central (Isfahan) part of Iran. The frequency of cagA-positive strains in Mashad and Isfahan were 63.4% and 56.7%, respectively. The pattern of EPIYA motif was as follows: 43 (79.6%) ABC, 7 (12.9%) AB, 4 (7.4%) ABCC, and one (1.9%) ABCCC. We also identified a novel EPIYA C sequence motif which showed association with gastric cancer (GC). The relationship between the frequency of specific EPIYA motifs and GC was statistically significant (P < 0.05).

Conclusions:
This is the first report for the determination of the cagA EPIYA motif of H. pylori in the Northeast and center of Iran. The prevalence of cagA positive H. pylori between the two regions was significant (P ≤ 0.05). All isolates of the H. pylori cagA were western type (ABC). The increase in the number of EPIYA-C repeats was associated with GC (P ≤ 0.01).
Linking Farmers' Perception of Biodiversity, Subjective Well-being and Conservation in the Tandilia System in the Southern Pampas of Argentina
Authors: De Rito Mara , Auer Alejandra , Mikkelsen Claudia , Herrera Lorena 
Published: September 2022

Much research has focused on the study of society-nature relations, guided by people's perception of nature, well-being and environmental behaviour in relation to this interplay. The perception of farmers on these topics has been less explored, but it is fundamental to enquire into this issue in order to understand the decisions they make in their production units and how these decisions influence their environment. This research explored the link between farmers' perception of biodiversity, their subjective well-being, and conservation practices in the Tandilia System in the Southern Pampas of Argentina. The information obtained from semi-structured interviews with farmers was analysed through Thematic Analysis. Potential associations between farmers' perceptions of biodiversity, subjective well-being and land management practices were investigated. Although most farmers were aware that agricultural practices negatively affect biodiversity and that contact with nature generates well-being, inconsistent narratives were noted when they talked about their own practices. Their awareness of biodiversity and well-being does not necessarily translate into more sustainable practices.Abstract in Spanish: https://bit.ly/3zy5pq8
Exploring a Comprehensive Behavioural Model to Investigate Illegal Sea Turtle Trade in Cabo Verde
Authors: Ribeiro Morgan Casal , Patino-Martinez Juan , Agues Janete , Marçal-Correia Alexandra , Nuno Ana 
Published: September 2022

Successful conservation outcomes often depend on changing human behaviours that negatively impact biodiversity, such as unsustainable wildlife harvesting or illegal wildlife trade (IWT). However, inclusive psychology models that examine motivations of those behaviours have been underutilised in IWT contexts. This research examines the drivers of illegal harvesting and consumption of sea turtles on Maio, Cabo Verde (West Africa), by adapting data from interviews (n=20) and questionnaires (n=325) into the Comprehensive Action Determination Model, an environmental psychology theoretical framework. Initial findings suggest local behavioural motivations have changed over time, but key beliefs remained intact. Structural equation modelling showed intention to consume turtles is influenced by positive attitudes towards consumption, but interviews suggest normative personal and social beliefs are becoming relevant to consumptive behaviour mitigation. The same seems true of harvesting, reportedly performed mostly by young men looking to sell turtle by-products. Overall, results indicate the beliefs underlying harvest and consumption behaviours are distinct, such that outreach initiatives must be designed to address each. Results demonstrate how conceptual models developed in underutilised disciplines can be adapted to expand the transdisciplinary tools available to conservation practitioners. Embracing behaviour-focused approaches is crucial to address the intricate cultural and contextual factors of IWT.
Abstract in Portuguese: https://bit.ly/3Aj9xuu
Relationship between Dermatitis and Joint Replacement
Authors: Jung Joon Woo , Son Minkook , Jeong Soo Hyun , Kim Kwang Joong , Kim Kwang Ho , Park Eun Joo 
Published: September 2022

Background:
Joint replacement is an important surgery for replacing a damaged joint with prosthesis. Implants used for joint replacement are made of metal, plastic, and ceramic. Skin reactions, such as dermatitis, can occur due to a hypersensitivity to these external substances.

Aims:
The aim of this study was to find the relationship between joint replacement and dermatitis.

Methods:
A nationwide population-based retrospective cohort study was performed using the National Health Insurance Service Database of the Republic of Korea. A total of 40,218 patients who underwent joint replacement were enrolled as the operation group and 40,218 controls were also enrolled. A cox proportional hazard regression model, and Fine and Gray regression model were used to compare the risk of dermatitis between the two groups.

Results:
Dermatitis occurred in 9.2% of the operation group and 9.1% of the control group, and no statistical difference was observed between the two groups. According to the Cox proportional hazard regression model, and Fine and Gray regression model, the risk of dermatitis did not increase in the operation group compared to that in the control group. However, the risk of dermatitis increased 1.20-fold in the operation group compared to that in the control group aged <60 years according to the Fine and Gray regression model (95% confidence index (CI) = 1.05–1.37, P = 0.0008). Conversely, no difference in dermatitis risk was observed between the two groups aged ≥60 years.

Conclusions:
We found that the risk of dermatitis increased after joint replacement in those aged <60 years.