bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prevalence of and Factors Associated With Anxiety and Depression Among Working-Age Adults in Mainland China at the Early Remission Stage of the Coronavirus 2019 Pandemic
Authors: Xie Haixia , Huang Xiaowei , Zhang Qi , Wei Yan , Zeng Xuheng , Chang Fengshui , Wu Shuyin 
Published: March 2022

BackgroundThe Coronavirus 2019 (COVID-19) outbreak has led to a considerable proportion of adverse psychological symptoms in different subpopulations. This study aimed to investigate the status of anxiety and depression and their associated factors in the adult, working-age population in Mainland China at the early remission stage of the COVID-19 pandemic.MethodsAn online study was conducted among 1,863 participants in 29 provinces in Mainland China from March 23 to 31, 2020. Their mental health was evaluated by the generalized anxiety disorder scale (GAD-7) and the patient health questionnaire (PHQ-9). Descriptive analysis, Chi-square, and multiple logistic regressions were applied.ResultsAbout 44.5% of the participants had anxiety, 49.2% had depression, and 37.9% showed a combination of depression and anxiety. Around 83.7% of the participants claimed that the pandemic had a negative impact on their medical needs, which was the primary predictor of mental health, the degree of impact being positively related to the prevalence of anxiety and depression. More chronic diseases, moderate to bad self-rated health, severe perceived infection risk, and younger age group were the common risk factors for anxiety and depression. Having no children, unemployment, and a college-level educational background were associated with higher anxiety prevalence, whereas unmarried participants were correlated with higher depression prevalence.ConclusionThe working-age population showed a relatively high risk of anxiety and depression in Mainland China at the early remission stage of the pandemic. To improve medical services capacity for routine and delayed medical service needs should be a part of policy-makers’ priority agenda during this period of crisis.
The Relationship Between the NSP and the Individual and Work Organizational Variables: A Cross-Sectional Study
Authors: Yuan Sue , Li Yunxia , Zhang Lihui , Wang Honghong 
Published: March 2022

ObjectivesTo investigate the characteristics of neck–shoulder pain (NSP) and explore the potentional relationship between the NSP and the individual and work organizational variables.MethodsA cross-sectional study was performed in the tertiary general hospitals in Hunan Province, China between May 2019 and July 2019. A total of 2,030 healthcare workers were enrolled randomly in this study based on a three-stage stratified sampling method. The Neck Disability Index (NDI) was used to measure disability in subjects with neck pain. A self-administered questionnaire was used to assess the characteristics of individual and work organizational variables. The Mann–Whitney U test and the Kruskal–Wallis H test were applied to analyze the prevalence of pain intensity among groups. Multivariate linear regression analysis was performed to explore the potentional relationship between NSP and individual and work organizational variables using the NDI score as the dependent variable.Results2,008 of 2,030 healthcare workers filled out the survey questionnaires online. In the past 12 months, 1,489 participants (74.2%) complained of pain in the cervical–shoulder region. NDI score increased by 0.10 for each year of age, with healthcare workers working in Obstetrics and Gynecology, and the Operating Room less likely to have NSP than those working in other departments. In contrast, female healthcare workers with a history of pregnancy were more likely to have NSP. In terms of organizational factors, workers who received concern from their supervisor about their health, who had the choice to change their shift status to off duty when they were not feeling well, or who were informed about WMSDs were less likely to have NSP.ConclusionThe prevalence of NSP within the previous year was high in this population. Individual factors including history of neck–shoulder diseases, age, and history of pregnancy and organizational factors including being adequately informed regarding WMSDs, concern from supervisors about workers' health, and the ability of workers to change their shift status to off duty when they were not feeling well were shown to induce significant effects to NSP.
Female Off-Farm Employment and Fertility Timing in Rural China
Authors: Shen Zheng , Zhao Zhao , Ren Qisheng , Yan Mingwei 
Published: March 2022

BackgroundAdvanced maternal age is associated with fetal outcomes such as higher risks of birth defects and very low birth weight. Off-farm employment is an important factor in fertility transition in many developing countries. This study investigated the association between off-farm employment and fertility timing among Chinese rural women.MethodUsing data from the China Labor-force Dynamics Survey (CLDS), we employed the ordinary least squares and instrumental variable approaches to estimate the effect of female off-farm employment on fertility timing decisions as well as the differences in the effect across groups.ResultsThe results show that off-farm employment participation is significantly associated with a later age at first birth, and the effect is stronger for women participating in wage employment than in off-farm self-employment. The delayed effects on fertility timing are also more pronounced for less-educated women and low-income families, implying a heterogeneous effect in terms of women's socioeconomic status.ConclusionStudies of the relationship between women's off-farm employment and fertility timing in rural areas of developing countries remain limited. This study provides important insights on this topic, and it lends support to efforts to design effective policies and practices to facilitate female employment, childbearing, and health promotion.
Association of Metals and Metalloids With Urinary Albumin/Creatinine Ratio: Evidence From a Cross-Sectional Study Among Elderly in Beijing
Authors: Li Ang , Zhao Jiaxin , Liu Liu , Mei Yayuan , Zhou Quan , Zhao Meiduo , Xu Jing , Ge Xiaoyu , Xu Qun 
Published: March 2022

BackgroundEnvironmental exposure to toxic elements contributes to the pathogenesis of chronic kidney disease (CKD). Few studies focus on the association of urinary metals and metalloids concentrations with the urinary albumin/creatinine ratio (UACR) among elderly, especially in areas and seasons with severe air pollution.ObjectiveWe aimed to evaluate the associations of urinary metals and metalloids concentration with UACR, which is an early and sensitive indicator of CKD.MethodWe conducted a cross-sectional study among 275 elderly people in Beijing from November to December 2016, which has experienced the most severe air pollution in China. We measured 15 urinary metals and metalloids concentration and estimated their association with UACR using a generalized linear model (GLM). Bayesian kernel machine regression (BKMR) and quantile g-computation (qgcomp) models were also conducted to evaluate the combined effect of metal and metalloid mixtures concentration.ResultsOf the 275 elderly people included in the analysis, we found that higher urinary Cu concentration was positively associated with UACR using GLM (β = 0.36, 95% CI: 0.25, 0.46). Using the BKMR model, we found that the change in UACR was positively associated with a change in urinary Cu concentration from its 25th to 75th percentile value with all other metals and metalloids concentration fixed at their 25th, 50th, or 75th percentile levels. Urinary Cu concentration had the most significant positive contribution (59.15%) in the qgcomp model. Our finding was largely robust in three mixture modeling approaches: GLM, qgcomp, and BKMR.ConclusionThis finding suggests that urinary Cu concentration was strongly positively associated with UACR. Further analyses in cohort studies are required to corroborate this finding.
The Quality of Life and Its Relationship With Systemic Family Dynamics and Mental Health in Senior High School Students From Shaanxi, China
Authors: Yang Zhe , Shang Yijiang , Liang Ying , Zhang Haiyue , Yang Yifan , Wang Yue , Shang Lei , Zhang Yuhai 
Published: March 2022

ObjectiveTo explore the quality of life (QoL) status of senior high school students in the Shaanxi Province and the relationship of the QoL with systemic family dynamics and mental health.MethodsThis was a cross-sectional observational study in a sample of 1,402 senior high school students; students were asked to complete a questionnaire which comprised the 36-item Short Form Health Survey (SF-36) to assess the QoL, the Self-rating Scale of Systemic Family Dynamics (SSFD) for assessing family functioning, the Symptom Checklist-90-Revised (SCL-90-R) for assessing mental health and general demographic variables.ResultsGrades of senior high school students were defined as Grade 1 (first year), Grade 2 (second year), and Grade 3 (third year). Compared to Grade 3 students, Grade 1 students had higher scores in physical functioning, role-emotional, bodily pain, and reported health transition of the QoL over the last 1 year (P &lt; 0.05). Multiple linear regression showed that the place of residence, subscales of systemic family dynamics, somatization, and depression significantly affected the total QoL score. The results of SEM show that the SCL-90-R score fully mediated the association between the SSFD score and SF-36 score (indirect effect coefficient 0.055; 95% CI, 0.012–0.106; P = 0.042).ConclusionThe QoL score of senior high school students was low, particularly that of Grade 3 students, who consequently need more emotional support. By improving and enhancing systemic family dynamics, the QOL of high school students will improve and discovering and addressing their mental health problems will be easier.
System Architecture of a European Platform for Health Policy Decision Making: MIDAS
Authors: Shi Xi , Nikolic Gorana , Fischaber Scott , Black Michaela , Rankin Debbie , Epelde Gorka , Beristain Andoni , Alvarez Roberto , Arrue Monica , Pita Costa Joao , Grobelnik Marko , Stopar Luka , Pajula Juha , Umer Adil , Poliwoda Peter , Wallace Jonathan , Carlin Paul , Pääkkönen Jarmo , De Moor Bart 
Published: March 2022

BackgroundHealthcare data is a rich yet underutilized resource due to its disconnected, heterogeneous nature. A means of connecting healthcare data and integrating it with additional open and social data in a secure way can support the monumental challenge policy-makers face in safely accessing all relevant data to assist in managing the health and wellbeing of all. The goal of this study was to develop a novel health data platform within the MIDAS (Meaningful Integration of Data Analytics and Services) project, that harnesses the potential of latent healthcare data in combination with open and social data to support evidence-based health policy decision-making in a privacy-preserving manner.MethodsThe MIDAS platform was developed in an iterative and collaborative way with close involvement of academia, industry, healthcare staff and policy-makers, to solve tasks including data storage, data harmonization, data analytics and visualizations, and open and social data analytics. The platform has been piloted and tested by health departments in four European countries, each focusing on different region-specific health challenges and related data sources.ResultsA novel health data platform solving the needs of Public Health decision-makers was successfully implemented within the four pilot regions connecting heterogeneous healthcare datasets and open datasets and turning large amounts of previously isolated data into actionable information allowing for evidence-based health policy-making and risk stratification through the application and visualization of advanced analytics.ConclusionsThe MIDAS platform delivers a secure, effective and integrated solution to deal with health data, providing support for health policy decision-making, planning of public health activities and the implementation of the Health in All Policies approach. The platform has proven transferable, sustainable and scalable across policies, data and regions.
Cellular and Humoral Immune Responses and Breakthrough Infections After Two Doses of BNT162b Vaccine in Healthcare Workers (HW) 180 Days After the Second Vaccine Dose
Authors: Mangia Alessandra , Serra Nicola , Cocomazzi Giovanna , Giambra Vincenzo , Antinucci Stefano , Maiorana Alberto , Giuliani Francesco , Montomoli Emanuele , Cantaloni Paolo , Manenti Alessandro , Piazzolla Valeria 
Published: March 2022

BackgroundImmunity and clinical protection induced by mRNA vaccines against SARS-CoV-2 have been shown to decline overtime. To gather information on the immunity profile deemed sufficient in protecting against hospitalization, we tested IgG levels, interferon-gamma (IFN-γ) secretion, and neutralizing antibodies 180 days (d180) after the second shot of BNT162b vaccine, in HW.MethodsA total of 392 subjects were enrolled. All received BioNTech/Pfizer from February 2020 to April 2021. The vaccine-specific humoral response was quantitatively determined by testing for IgG anti-S1 domain of SARS-CoV-spike protein. Live virus microneutralization (MN) was evaluated by an assay performing incubation of serial 2-fold dilution of human serum samples, starting from 1:10 to 1:5120, with an equal volume of Wuhan strain and Delta VOC viral solution and assessing the presence/absence of a cytopathic effect. SARS-CoV-2-spike protein-specific T-cell response was determined by a commercial IFN-γ release assay.ResultsIn 352 individuals, at d180, IgG levels decreased substantially but no results below the assay's positivity threshold were observed. Overall, 22 naive (8.1%) had values above the highest threshold. Among COVID-naive, the impact of age, which was observed at earlier stages, disappeared at d180, while it remained significant for 81 who had experienced a previous infection. Following the predictive model of protection by Khoury, we transformed the neutralizing titers in IU/ml and used a 54 IU/ml threshold to identify subjects with 50% protective immunity. Overall, live virus MN showed almost all subjects with previous exposure to SARS-CoV-2 neutralized the virus as compared to 33% of naive double-dosed subjects (p &lt; 0.0001). All previously exposed subjects had strong IFN-γ secretion (&gt;200 mIU/ml); among 271 naive, 7 (2.58%) and 17 (6.27%) subjects did not show borderline or strong secretion, respectively.ConclusionsIn naive subjects, low IgG titers are relatively long-lasting. Only a third of naive subjects maintain neutralizing responses. After specific stimulation, a very limited number of naive were unable to produce IFN-γ. The results attained in the small group of subjects with breakthrough infection suggest that simultaneous neutralizing antibody titers &lt;20, binding antibody levels/ml &lt;200, and IFN-γ &lt;1,000 mIU/ml in subjects older than 58 may identify at-risk groups.
Clinical Course of COVID-19 Disease in Children Treated With Neoplastic Diseases in Hungary
Authors: Müller Judit , Szűcs-Farkas Dóra , Szegedi István , Csóka Monika , Garami Miklós , Tiszlavicz Lilla Györgyi , Hauser Péter , Kriván Gergely , Csanádi Krisztina , Ottóffy Gábor , Nagy Béla , Kiss Csongor , Kovács Gábor 
Published: March 2022

We report on children with cancer in Hungary suffering from COVID-19, surveying a 13-months-long period of time. We performed a retrospective clinical trial studying the medical documentation of children treated in seven centers of the Hungarian Pediatric Oncology-Hematology Group. About 10% of children admitted to tertiary hemato-oncological centers for anti-neoplastic treatment or diagnosis for de novo malignancies were positive for SARS-CoV-2 infection. Nearly two-thirds of the infected patients were asymptomatic or had only mild symptoms but showed seropositivity by 1–4.5 months after positive PCR. One third of the SARS-CoV-2-positive children were hospitalized due to symptomatic COVID-19. Five children required antiviral treatment with remdesivir. One child was referred to the intensive care unit, requiring intubation and mechanical ventilation. Delay in the scheduled anti-cancer treatment did not exceed 2 weeks in the majority (89%) of cases. There was only one patient requiring treatment deferral longer than a month. There was no COVID-19-related death in patients under 18 years of age, and nor was multisystem inflammatory syndrome diagnosed. In conclusion, SARS-CoV-2 infection did not represent an untoward risk factor among children with cancer in Hungary.
Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation
Authors: Zajíčková Markéta , Prchal Lukáš , Vokřál Ivan , Nguyen Linh Thuy , Kurz Thomas , Gasser Robin , Bednářová Klára , Mičundová Magdalena , Lungerich Beate , Michel Oliver , Skálová Lenka 
Published: March 2022

As a widely distributed parasitic nematode of ruminants, Haemonchus contortus has become resistant to most anthelmintic classes, there has been a major demand for new compounds against H. contortus and related nematodes. Recent phenotypic screening has revealed two compounds, designated as BLK127 and HBK4, that are active against H. contortus larvae. The present study was designed to assess the activity of these compounds against H. contortus eggs and adults, hepatotoxicity in rats and sheep, as well as biotransformation in H. contortus adults and the ovine liver. Both compounds exhibited no inhibitory effect on the hatching of eggs. The benzyloxy amide BLK127 significantly decreased the viability of adults in sensitive and resistant strains of H. contortus and showed no hepatotoxic effect, even at the highest concentration tested (100 µM). In contrast, HBK4 had no impact on the viability of H. contortus adults and exhibited significant hepatotoxicity. Based on these findings, HBK4 was excluded from further studies, while BLK127 seems to be a potential candidate for a new anthelmintic. Consequently, biotransformation of BLK127 was tested in H. contortus adults and the ovine liver. In H. contortus, several metabolites formed via hydroxylation, hydrolysis and glycosidation were identified, but the extent of biotransformation was low, and the total quantity of the metabolites formed did not differ significantly between the sensitive and resistant strains. In contrast, ovine liver cells metabolized BLK127 more extensively with a glycine conjugate of 4-(pentyloxy)benzoic acid as the main BLK127 metabolite.
Indoor Positioning of Low-Cost Narrowband IoT Nodes: Evaluation of a TDoA Approach in a Retail Environment
Authors: Neunteufel Daniel , Grebien Stefan , Arthaber Holger 
Published: March 2022

The localization of internet of things (IoT) nodes in indoor scenarios with strong multipath channel components is challenging. All methods using radio signals, such as received signal strength (RSS) or angle of arrival (AoA), are inherently prone to multipath fading. Especially for time of flight (ToF) measurements, the low available transmit bandwidth of the used transceiver hardware is problematic. In our previous work on this topic we showed that wideband signal generation on narrowband low-power transceiver chips is feasible without any changes to existing hardware. Together with a fixed wideband receiving anchor infrastructure, this facilitates time difference of arrival (TDoA) and AoA measurements and allows for localization of the fully asynchronously transmitting nodes. In this paper, we present a measurement campaign using a receiver infrastructure based on software-defined radio (SDR) platforms. This proves the actual usability of the proposed method within the limitations of the bandwidth available in the ISM band at 2.4 GHz. We use the results to analyze the effects of possible anchor placement schemes and scenario geometries. We further demonstrate how this node-to-infrastructure-based localization scheme can be supported by additional node-to-node RSS measurements using a simple clustering approach. In the considered scenario, an overall positioning root-mean-square error (RMSE) of 2.19 m is achieved.
Entrepreneurial Marketing and Organizational Entrepreneurship Performance of Small and Medium Enterprises: A Systematic Review
Authors: Shahmohammadi Batoul 
Published: March 2022

Objective: The purpose of this article was to systematically review the existing articles on entrepreneurial marketing and organizational entrepreneurship of small and medium enterprises. Research Design & Methods: For this purpose, English research related to the keywords entrepreneurial marketing, impact, organizational entrepreneurship and small and medium enterprises were searched in Elsevier, Emerald and Springer databases for the period 2018-2021. In the meantime, 12 related articles were extracted and studied. Findings: The results of this study showed that the dimensions of entrepreneurial marketing improve organizational entrepreneurship indicators in small and medium enterprises. Implications & Recommendations: Entrepreneurial marketing is one of the marketing strategies of small and medium enterprises that helps them grow through entrepreneurship. In fact, entrepreneurial marketing translates important aspects of marketing and entrepreneurship into a comprehensive conceptualization in which marketing becomes the method that firms use to do entrepreneurship. Contribution & Value Added: This article reviewed 12 most recent published articles in terms of entrepreneurial marketing and organizational entrepreneurship to pave the way of finding latest information in this regard.
To compare the Day-Time Phasing with One-Time Supine Position IOP in Patients with Primary Open Angle Glaucoma and Normal Tension Glaucoma
Authors: Mirza Aneeq Ullah Baig , Mehboob Asim , Arshad Muhammad Usman , Zia Sohail , Asrar Aamir 
Published: March 2022

Purpose: To compare the intraocular pressure (IOP) during 12 hour day-time phasing with one-time supine position IOP.
Study Design: Prospective, observational.
Place and Duration of Study: Glaucoma clinic of a tertiary eye – care center in Rawalpindi, Pakistan, from September 2020 to February 2021.
Methods: Forty two eyes of 21 participants with primary open angle and normal tension glaucoma were included in the study by convenient sampling technique. Three hourly diurnal Applanation tonometry was performed in sitting position from 9:00 am to 9:00 pm. Mean IOP and standard deviations were calculated. One-time supine position IOP was taken by Perkins tonometer at 9:10 pm. Mean IOP at 9:00 pm in sitting position was compared with the mean IOP in supine position.
Results: There were 15 males (71.42%) and 6 females (28.58%) in the study. Means of sitting position IOP during different times of the day ranged between 16.64 and 18.16 mmHg. The mean of IOP measured at 9:00am, 12:00 pm, 3:00 pm, 6:00 pm and 9:00 pm was 17.62 ± 4.04 mmHg. Mean supine position IOP at 9:10 pm was 22.38 ± 5.92 mmHg. Mean difference between supine and sitting position IOP was 4.75 ± 3.65 mmHg. This was statistically significant p-0.001.Direct comparison between sitting and supine IOP at 9:00 pm and 9:10 pm revealed the values to be 17.88 and 22.38 mmHg respectively (p < 0.001).
Conclusion: One-time supine position IOP gives a higher value than any one – time of IOP recorded during 12-hour diurnal phasing performed in sitting position.
Key Words: Intra ocular pressure, diurnal phasing, Primary open angle glaucoma, Normal tension glaucoma.