bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Inhibitory Effects of Fluoxetine on Secretion of Inflammatory Mediators and Genes Expression of JAK/STAT3 and JNK/TLR4
Authors: forushani Hoda Mojiri , Khajehali Elham , Adelipour Maryam , Mohammadi Asma 
Published: September 2022

Abstract
Background
Selective serotonin reuptake inhibitors (SSRIs) as the commonest therapeutic option are used to treat major depression. Recent studies have reported an association between depression and inflammation as well as the significant effect of SSRIs on inflammatory processes.
Methods
The current research was done to evaluate the impact of fluoxetine as a SSRI on the level of key inflammatory cytokines, interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α), in rat serum and RAW264.7 macrophages using ELISA sandwich assays. We also assessed the expression of inflammatory genes, JAK/STAT3 and TLR4/ JNK, in macrophages using quantitative real-time RT-PCR to elucidate the potential mechanism of fluoxetine on inflammation process. Rats received fluoxetine (10, 20, 40 mg/kg), 30 minutes before treatment with lipopolysaccharide (LPS) for 90 minutes and cells received different doses (5, 10, 20 µg/ml) of fluoxetine prior to 24 or 48 h stimulation with LPS.
Results
The serum concentrations of IL-1β, IL-6 and TNF-α reduced in rats and cells pre-treated with fluoxetine. The expression of JAK/STAT3 and TLR4/ JNK genes was significantly decreased by fluoxetine in RAW264.7 cells treated for 24 h with LPS. However, fluoxetine failed to reduce the elevated expression of JAK and JNK but significantly decreased the gene expression of STAT3 and TLR4 after 48 h treatment with LPS.
Conclusions
Our data demonstrates that fluoxetine has anti-inflammatory properties, mainly due to reduction of inflammatory cytokines and the inhibition of JAK/STAT3 and TLR4/ JNK genes expression in macrophages.
Binocular Stereo Matching Based on SGM and Flood Filling Algorithm
Authors: Song Kun , YI Huaian , Shu Aihua , Song Xinru , Huang Jiefeng 
Published: September 2022

Abstract
The SGM algorithm was weak in matching the occluded area and parallax discontinuity area in stereo matching, and it was easy to produce more voids. To address this question, the paper proposes a parallax optimizati-on algorithm based on SGM algorithm combined with flood filling and median smoothing. The algorithm fills the missing parallax values based on the parallax values at the edges of the voids and achieves the repair of the missing parallax in the parallax map without raising a large computational effort. The proposed algorithm has also been qua-ntitatively analyzed on the Middlebury stereo matching dataset using three evaluation metrics: root mean square error (RMSE), peak signal-to-noise ratio (PSNR), and structural similarity (MSSIM). The experimental results show that the improvement and optimization of the SGM algorithm can effectively fill the voids in the parallax map and reduce the noise of the image, and the matching accuracy of parallax maps is improved by an average of 9%.
Platelet to Lymphocyte Ratio as an Inflammatory Marker in Perthes disease
Authors: Wang TianTian , Luo XiaoLin , Li BoXiang , Huang Qian , Liu JianHong , Tang ShengPing , Liu Yun , Lu RongBin , Liao ShiJie , Ding XiaoFei. 
Published: September 2022

Abstract
Objective: To investigate the relationship between NLR(lymphocyte ratio), PLR(platelet to lymphocyte ratio), LMR(lymphocyte to monocyte ratio) and PNS(platelet to neutrophil ratio) and the lateral pillar classificationof Perthes disease, and to provide an alternative index for clinical diagnosis and prognosis.
Methods: 59 children with Perthes disease and 60 children in the healthy control group without femoral head necrosis in our hospital from 2012 to 2021 were collected. The general data were collected. The modified herring lateral pillar classification was collectedfor the case group, and the inflammatory factors NLR, PLR, LMR and PNS were collected. The cases were divided into three groups, herring A and B were group I, herring B/C and C were group II, and the healthy control group was group III. The hematological indexes (NLR, PLR, LMR, PNS) of children at different stages were statistically analyzed.
Results: Group I consisted of 36 patients, with an average age of 7.4 ± 2.0 years (3–11 years). Group II consisted of 23 patients, with an average age of 7.4 ± 1.9 years (4–12 years). Group III consisted of 60 patients, with a mean age of 7.4 ± 2.7 years (4–13 years). The average values of PLR in groups I, II and III were 131.98 ± 47.44, 122.19 ± 37.88 and 102.46 ± 30.68, respectively. It's worth noting that there was statistically significant difference among these groups (P=0.003). The optimal threshold of PLR was 130.25, the sensitivity was 45.8% and the specificity was 85%.
Conclusion: PLR has certain value in the diagnosis of Perthes disease. The higher the value of PLR, the higher the risk of Perthes disease.
Revision of the fall risk self-assessment scale for community-dwelling older adults and assessment of reliability and validity
Authors: Guo Aixin , Gu Li , Yang Yanyan , Dai Hongle , Wang Zhizhuo , Wen Chang , Zhou Mouwang 
Published: September 2022

Abstract
Background: Fall is a common accidental injury of the older people, which seriously threatens their physical and mental health. The occurrence of fall often due to the interaction of multiple risk factors. The Fall Risk Self-Assessment Scale (FRSAS) is a multi-dimensional fall risk assessment tool. Pre-experiments have shown that the first version of FRSAS can be used for assessing the fall risks of the older people in communities, with strong operability and good reliability and validity. This study aims at further optimizing the items of the Scale through large sample survey, and assessing the reliability and validity of the revised FRSAS.
Methods: This study is a cross-sectional study, using the convenient sampling method. A total of 500 older adults aged 65 and above were recruited from four health service centers in Beijing from October 2021 to March 2022. Among whom, 489 subjects completed FRSAS as required, and the effective response rate of the Questionnaire was 97.8%; 44 subjects completed the repeated survey with the repeated measurement rate of 8.8%. The items of FRSAS were analyzed and screened to form the final version of the Scale with the comprehensive screening method, and the reliability and validity of the final version of the Scale were tested.
Results: The items of the Scale were compared and analyzed with the comprehensive screening method, of which, six items, namely D1, P12, C3, C9, C10 and H11, with two or more screening methods prompt to be deleted. After discussion by the experts, they agreed to delete the above 6 items and adjust the structure of the final FRSAS to 35 items and 4 dimensions. The Cronbach's α coefficient of the final FRSAS was 0.783 and the test-retest reliability was 0.98. Taking whether the subjects had a history of fall in the past year as the grouping variable, the total score of the Scale was tested by T test, and the difference between both groups was statistically significant (P =0.000).
Conclusion: The revision of the final version of FRSAS meets the actual needs of the older people in communities, with simple items and better reliability and validity. FRSAS can be used as an important reference tool for assessing the risks of fall in the older people in communities.
Trial registration: Registration number: ChiCTR2000038856; Date of registration:7 Oct 2020.
Children with severe enterovirus 71 infection
Authors: Wu Wenjuan , Li Baoguang , Xie Tao 
Published: September 2022

Abstract
Background
There are few reports on the timing of onset and characteristics of the symptoms of enterovirus 71 (EV71) infection, which can easily be misjudged by clinicians. This study is aimed to explore the clinical characteristics of children with severe EV71 infection.
Methods
This retrospective observational study included children with severe EV71 infection who were admitted to Hebei Children’s Hospital between January 2016 and January 2018.
Results
A total of 101 patients were enrolled, with 57 males (56.4%) and 44 females (43.6%). They were 1–13 years of age. The symptoms were fever in 94 patients (93.1%), rash in 46 (45.5%), a susceptible mood in 70 (69.3%), and lethargy in 56 (55.4%). There were 19 (59.3%) cases with abnormal neurological magnetic resonance imaging [pontine tegmentum (n = 14, 43.8%), medulla oblongata (n = 11, 34.4%), midbrain (n = 9, 28.1%), cerebellum and dentate nucleus (n = 8, 25.0%), basal ganglia (n = 4, 12.5%), cortex (n = 4, 12.5%), spinal cord (n = 3, 9.3%), and meninges]. There was a positive correlation between the ratio of neutrophil count and white blood cell count in CSF in the first 3 days of the course of the disease (r = 0.415, P < 0.001).
Conclusion
The clinical symptoms of EV71 infection are fever and/or skin rash, easy convulsion, and lethargy. Some patients were with abnormal neurological magnetic resonance imaging. The white blood cell count in the cerebrospinal fluid of children with EV71 infection may increase with the ratio of peripheral blood neutrophils in the cerebrospinal fluid of children with EV71 infection.
Novel Platform Assays for the Diagnosis of Hemostatic Disorders: A Systematic Review
Authors: Alzahrani Faisal 
Published: September 2022

Abstract
Background
In hemostasis research the novel platform assays for the diagnosis of hemostatic disorders were limited. The purpose of the present review study would be to make a comparison between several assays for assessing the novel hemostatic techniques used in the diagnosis of coagulation disturbance and to point out the most advantageous and disadvantageous aspects of each method as a predictor of morbidity and mortality to determine hemostatic efficacy as well as biological safety.
Methods
The current systematic review follows the guidelines for observational studies in epidemiology and the PRISMA guidelines. The keywords were used to search the electronic databases (PubMed) (a novel platform to evaluate hemostasis). Searches were restricted to articles published between December 2016 and December 2021; original articles were written in English. To summarize, we collected bibliographies of abstract articles published on a novel platform to evaluate hemostasis studies,
Results
Following the removal of duplicates, articles were determined by examining the titles and abstracts. Disagreements were resolved through consensus and the application of novel hemostatic analysis methods. The researchers independently reviewed the relevant studies of the recognized records (n = 503), excluding duplicates (n = 9) and irrelevant studies (249). The remaining 254 studies were read in their entirety, and the data from the seven included studies had been extracted
Conclusion
Nanotechnology-Based Published study formulations discovered it is more optimal for some lab tests when expressed as an anticoagulant for the in vivo evaluation of nanoparticle implications on the complement system, and flow cytometer evaluation could be a promising platform approach for use in hemostasis managers.
Establishment of a risk prediction model for prolonged mechanical ventilation after lung transplantation: a retrospective cohort study
Authors: Gao Peigen , Li Chongwu , Wu Junqi , Ning Ye , Zhang Pei , Liu Xiucheng , Li Yuping , Ding Junrong , Su Yiliang , Zhu Yuming , He Wenxin , Chen Chang 
Published: September 2022

Abstract
Background
Prolonged mechanical ventilation (PMV), mostly defined as mechanical ventilation > 72 hours after lung transplantation (LuTx) with or without tracheostomy, is associated with increased mortality. Nevertheless, the predictive factors of PMV after LuTx remain unclear. The present study aimed to develop a novel scoring system to identify PMV after LuTx.
Methods
A total of 141 patients who underwent lung transplantation were investigated in this study. The patients were divided into PMV and non-prolonged ventilation (NPMV) groups. Univariate and multivariate logistic regression analyses were performed to assess factors associated with PMV. A risk nomogram was then established based on the multivariate analysis, and model performance was further examined regarding its calibration, discrimination, and clinical usefulness.
Results
Eight factors were finally identified to be significantly associated with PMV by the multivariate analysis and therefore were included as risk factors in the nomogram as follows: the body mass index (BMI, P = 0.036);primary diagnosis as idiopathic pulmonary fibrosis (IPF, P = 0.038); pulmonary hypertension (PAH, P = 0.034); primary graft dysfunction grading (PGD, P = 0.011) at T0; cold ischemia time (CIT P = 0.012); and three ventilation parameters (peak inspiratory pressure [PIP, P < 0.001], dynamic compliance [Cdyn, P = 0.001], and P/F ratio [P = 0.015] ) at T0. The nomogram exhibited superior discrimination ability with an area under the curve (AUC) of 0.895. Furthermore, both calibration curve and decision-curve analysis (DCA) indicated satisfactory performance.
Conclusion
A novel nomogram to predict individual risk of receiving PMV for patients after LuTx was established, which may guide preventative measures for tackling this adverse event.
Randomized Controlled Trial of Remote ISchemic Preconditioning in Children Having Cardiac Surgery
Authors: Law Yuk M. , Hsu Christine , Katz Ronit , Hingorani Sangeeta R. , Richards Michael , McMullan David M. , Jefferies Howard , Himmelfarb Jonathan 
Published: September 2022

Abstract
Background
Children undergoing cardiac surgery are at risk for acute kidney injury (AKI) and cardiac dysfunction. Opportunity exists in protecting end organ function with remote ischemic preconditioning. We hypothesize this intervention lessens kidney and myocardial injury.
Methods
We conducted a randomize, double blind, placebo controlled trial of remote ischemic preconditioning in children undergoing cardiac surgery. Pre-specified end points are change in creatinine, estimated glomerular filtration rate, development of AKI, B-type natriuretic peptide and Troponin I at 6, 12, 24, 48, 72 hours post separation from bypass.
Results
There were 45 in the treatment and 39 patients in the control group, median age of 3.5 and 3.8 years, respectively. There were no differences between groups in creatinine, cystatin C, eGFR at each time point. There was a trend for a larger rate of decrease, especially for cystatin C (p=0.042) in the treatment group but the magnitude was small. AKI was observed in 21 (54%) of control and 16 (36%) of treatment group (p=0.094). Adjusting for baseline creatinine, the odds ratio for AKI in treatment vs. control was 0.31 (p=0.037); adjusting for clinical characteristics, the odds ratio was 0.34 (p=0.056). There were no differences in natriuretic peptide or troponin levels between groups. All secondary end points of clinical outcomes were not different.
Conclusions
There is suggestion of RIPC delivering some kidney protection in an at-risk pediatric population. Larger, higher risk population studies will be required to determine its efficacy.
Trial registration and date: Clinicaltrials.gov NCT01260259; 2021.
Impact of fractionated stereotactic radiotherapy on activity of daily living and performance status in progressive/recurrent glioblastoma: a retrospective study.
Authors: Demogeot Nicolas , Salleron Julia , Rech Fabien , Taillandier Luc , Royer Philippe , Vogin Guillaume 
Published: September 2022

Abstract
Background
The prognosis of recurrent glioblastoma (GBM) is poor, with limited options of palliative localized or systemic treatments. Survival can be improved by a second localized treatment; however, it is not currently possible to identify which patients would benefit from this approach. This study aims to evaluate which factors lead to a lower Karnofsky Performance Status (KPS) score after fractionated stereotactic RT (fSRT).
Methods
We retrospectively collected data from patients treated with fSRT for recurrent GBM at the Institut de Cancérologie de Lorraine between October 2010 and November 2017 and analyzed which factors were associated with a lower KPS score.
Results
59 patients received a dose of 25 Gy in 5 sessions spread over 5–7 days (80% isodose). The median time from the end of primary radiotherapy to the initiation of fSRT was 10.7 months. The median follow-up after fSRT initiation was 8.8 months. The incidence of KPS and ADL impairment in all patients were 51.9% and 37.8% respectively with an adverse impact of PTV size on KPS (HR = 1.57 [95%-CI, 1.19–2.08], p = 0.028). Only two patients showed early grade 3 toxicity and none showed grade 4 or late toxicity. The median overall survival time, median overall survival time after fSRT, median progression-free survival and institutionalization-free survival times were 25.8, 8.8, 3.9 and 7.7 months, respectively. Initial surgery was associated with better progression-free survival (Hazard ratio (HR) = 0.48 [95%-CI, 0.27–0.86], p = 0.013).
Conclusions
A larger PTV should predicts lower KPS in the treatment of recurrent GBM using fSRT.
Small targets detection in dual-energy X-ray images of coal and gangue based on APSO-C_Otsu
Authors: Zhao Yanqiu , Wang Shuang , Guo Yongcun , He Lei , Wang Wenshan 
Published: September 2022

Abstract
The positioning accuracy of coal and gangue is related to the discharge accuracy of gangue, which will affect the utilization rate of coal. But the detectability of the small coal and gangue is poor due to the fewer number of pixels and texture information in coal and gangue dual-energy X-ray images. So, the Otsu with crotch structure based on Adaptive Partical Swarm Optimization (APSO) for small targets detection is proposed, called after APSO-C_Otsu. Firstly, the Otsu with crotch structure is used to perform multi-threshold segmentation of coal and gangue dual-energy X-ray images to increase the contrast between small target and background. Meanwhile, the APSO algorithm was used to optimize the Otsu algorithm with crotch structure in order to improve its convergence speed and reduce its calculation amount. Finally, the processed image is binarized, and the location of the target was labeled based on the bwlabel algorithm. The experimental results revealed that the APSO-C_Otsu algorithm could effectively detect the small pixel size (less than 8 × 8 pixels) of coal and gangue with a particle size of 6 ~ 30 mm, and was also applicable to the coal and gangue with the particle size larger than 30 mm, which was of great significance for accurate separation of coal and gangue and the improvement of coal utilization.
Preoperative computed tomography-guided transscapular Sens-cure needle localization for pulmonary nodule located behind the scapula
Authors: Lu Zi-Wei , Liu Yue-Yue , Li Yong-Gang , Lv Lu-Lu 
Published: September 2022

Abstract
Background
Video-assisted thoracoscopic surgery (VATS) is an approach that is commonly used to treat pulmonary nodules (PNs). However, when these PNs are located behind the scapula, a transscapular access approach is generally required. In this study, the safety, efficacy, and feasibility of preoperative computed tomography (CT)-guided Sens-cure needle (SCN) localization was assessed for PNs located behind the scapula.
Methods
From January 2020 - June 2022, a total of 122 PN patients in our hospital underwent preoperative CT-guided SCN localization and subsequent VATS resection, of whom 12 (9.8%) exhibited PNs behind the scapula necessitating a transscapular approach for this localization procedure.
Results
This study included 12 patients, each of whom had one PN located behind the scapula. The CT-guided transscapular SCN localization approach was successful in all patients, and no complications near the operative site were observed. The median localization time was 12 min, and 2 (16.7%) and 1 (8.3%) patients respectively developed pneumothorax and pulmonary hemorrhage after the localization procedure was complete. Wedge resection procedures for these PNs achieved technical success in all cases. Four patients were diagnosed with invasive adenocarcinomas and subsequently accepted lobectomy and systematic lymph node dissection. The median VATS duration and the median blood loss was 10 mL. In total, 3, 5, and 4 PNs were respectively diagnosed as benign, mini-invasive adenocarcinomas, and invasive adenocarcinomas.
Conclusion
Preoperative CT-guided transscapular SCN localization represents a safe, straightforward, and effective means of localizing PNs present behind the scapula.
The influence of astrocytic leaflet motility on ionic signalling and homeostasis at active synapses.
Authors: Toman Marinus , Wade John , Verkhratsky Alexei , Dallas Mark , Bithell Angela , Flanagan Bronac , Harkin Jim , McDaid Liam 
Published: September 2022

Abstract
Astrocytes display a highly complex, spongiform morphology, with their fine terminal processes (leaflets) exercising dynamic degrees of synaptic coverage, from touching and surrounding the synapse to being retracted from the synaptic region. In this paper, a computational model is used to reveal the effect of the astrocyte-synapse spatial relationship on ionic homeostasis. Specifically, our model predicts that varying degrees of astrocyte leaflet coverage influences concentrations of K+, Na+ and Ca2+, and results show that leaflet motility strongly influences Ca2+ uptake, as well as glutamate and K+ to a lesser extent. Furthermore, this paper highlights that an astrocytic leaflet that is in proximity to the synaptic cleft loses the ability to form a Ca2+ microdomain, whereas when the leaflet is remote from the synaptic cleft, a Ca2+ microdomain can form. This may have implications for Ca2+-dependent leaflet motility.
Assortativity in cognition
Authors: Bilancini Ennio , Boncinelli Leonardo , Vicario Eugenio 
Published: September 2022

Abstract
In pairwise interactions assortativity in cognition means that pairs where both decision-makers use the same cognitive process are more likely to occur than what happens under random matching. In this paper, we study both the mechanisms determining assortativity in cognition and its effects. In particular, we analyze an applied model where assortativity in cognition helps explain the emergence of cooperation and the degree of prosociality of intuition and deliberation, which are the typical cognitive processes postulated by the dual process theory in psychology.Our findings rely on agent-based simulations, but analytical results are also obtained in a special case. We conclude with examples showing that assortativity in cognition can have different implications in terms of its societal desirability.