bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of chemokines in the crosstalk between tumor and tumor-associated macrophages
Authors: Qin Rui , Ren Weihong , Ya Guoqi , Wang Bei , He Jiao , Ren Shaoxin , Jiang Lu , Zhao Shuo 
Published: September 2022

AbstractTumor microenvironment (TME) consists of a dynamic network of non-tumoral stromal cells, including cancer-associated fibroblasts, endothelial cells, tumor-associated macrophages (TAMs), B and T cells. In the TME, TAMs support tumor initiation, progression, invasion and metastasis by promoting angiogenesis and immunosuppression of the tumor cells. There is close crosstalk between TAMs and tumor cells. Notably, chemokines are a significant messenger mediating the crosstalk between tumor cells and TAMs. TAMs can promote tumor progression via secretion of chemokines. Various chemokines secreted by tumors are involved in the generation and polarization of TAMs, the infiltration of TAMs in tumors, and the development of TAMs' suppressive function. This paper reviews CCL2-CCR2, CCL3/5-CCR5, CCL15-CCR1, CCL18-CCR8, CX3CL1/CCL26-CX3CR1, CXCL8-CXCR1/2, CXCL12-CXCR4/CXCR7 signaling pathways, their role in the recruitment, polarization and exertion of TAMs, and their correlation with tumor development, metastasis and prognosis. Furthermore, we present the current research progress on modulating the effects of TAMs with chemokine antagonists and discuss the prospects and potential challenges of using chemokine antagonists as therapeutic tools for cancer treatment. The TAMs targeting by chemokine receptor antagonists in combination with chemotherapy drugs, immune checkpoint inhibitors or radiotherapy appears to be a promising approach.
Fluid inclusion characteristics of the Jurassic reservoir and hydrocarbon accumulation process in the eastern Kuqa Depression, Tarim Basin
Authors: Wan Jialin , Gong Yanjie , Zhuo Qingong , Lu Xuesong , Huang Wenhui 
Published: September 2022

AbstractThere has been significant progress in hydrocarbon exploration of the eastern Kuqa Depression, Tarim Basin, whose Jurassic reservoir is a key area for abundant hydrocarbon with poorly understood accumulation mechanism. This study conducts an integrated investigation comprising petrographic observations, microthermometry measurements, and fluorescence spectroscopy analyses on fluid inclusions to reconstruct hydrocarbon accumulation history in the Jurassic reservoir. These conclusions are combined with biomarker characteristics to reveal the burial history and thermal evolution of the study area. The results show that (1) there were two episodes of oil charging that occurred at 6~4 Ma and 4~2 Ma, respectively. The QGF experiment response and yellow fluorescent oil inclusions indicated that low-maturity medium crude oil from the Triassic source rocks was expelled into the upper Ahe Formation. In the second charging stage, some mature oil generated from Jurassic source rocks was charged into the reservoir of the Kezilenuer and Yangxia formations, while the condensate from the Triassic source rocks was migrated upward to the Jurassic reservoir, consistent with smaller QGF-E intensity values and blue-white fluorescent petroleum inclusions. (2) There were two kinds of hydrocarbon accumulation models including the lower-generation and upper-storage and the self-generated and self-stored models. (3) It was noted that active faults were developed under the compression stress to provide channels for hydrocarbon vertical migration. Moreover, the early reservoir was destroyed resulting from the strata denudation and a large amount of crude oil was escaped to the surface. The findings of this study can help for better understanding of hydrocarbon accumulation mechanism in the eastern Kuqa Depression and provide theoretical guidance for further oil and gas exploration.
Harnessing Biomaterials for Immunomodulatory-Driven Tissue Engineering
Authors: Zhong Justin X. , Raghavan Preethi , Desai Tejal A. 
Published: September 2022

Abstract

The immune system plays a crucial role during tissue repair and wound healing processes. Biomaterials have been leveraged to assist in this in situ tissue regeneration process to dampen the foreign body response by evading or suppressing the immune system. An emerging paradigm within regenerative medicine is to use biomaterials to influence the immune system and create a pro-reparative microenvironment to instigate endogenously driven tissue repair. In this review, we discuss recent studies that focus on immunomodulation of innate and adaptive immune cells for tissue engineering applications through four biomaterial-based mechanisms of action: biophysical cues, chemical modifications, drug delivery, and sequestration. These materials enable augmented regeneration in various contexts, including vascularization, bone repair, wound healing, and autoimmune regulation. While further understanding of immune-material interactions is needed to design the next generation of immunomodulatory biomaterials, these materials have already demonstrated great promise for regenerative medicine.

Lay Summary
The immune system plays an important role in tissue repair. Many biomaterial strategies have been used to promote tissue repair, and recent work in this area has looked into the possibility of doing repair by tuning. Thus, we examined the literature for recent works showcasing the efficacy of these approaches in animal models of injuries. In these studies, we found that biomaterials successfully tuned the immune response and improved the repair of various tissues. This highlights the promise of immune-modulating material strategies to improve tissue repair.
Systematic Review of Virtual Reality in Behavioral Interventions for Individuals with Autism
Authors: Carnett Amarie , Neely Leslie , Gardiner Siobhan , Kirkpatrick Marie , Quarles John , Christopher Kameron 
Published: September 2022

Abstract
Objectives
Virtual reality technology is able to simulate real life environments and has been used to facilitate behavioral interventions for people with autism. This systematic review aims to evaluate the role of virtual reality (VR) technology in the context of behavioral interventions designed to increase behaviors that support more independent functioning (e.g., teach vocational skills, adaptive behavior) or decrease challenging behaviors that interfere with daily functioning for individuals with autism.

Methods
We conducted a systematic search in four databases followed by a reference search for those articles identified by the systematic database search. We also conducted a quality review using the evaluative method for evaluating and determining evidence-based practices in autism.

Results
We identified 23 studies with a majority of the studies (n = 18; 75%) utilizing group experimental or quasi-experiment research design and the remaining (n = 5; 21.74%) utilizing single-case research design. Of those studies, targeted behavior includes vocational skills (n = 10), safety skills (n = 4), functional behaviors (n = 2), and challenging behavior (n = 7). Of the 23 studies, 11 met the quality criteria to be classified as “strong” or “adequate” and can offer evidence on the integration of VR technology into behavioral interventions.

Conclusions
The use of VR to provide behavioral interventions to teach driving skills and to teach interview skills can be considered an evidence-based practice.
Using Implementation Science to Inform Workforce and Service Development in Youth Mental Health: An Australian Case Study
Authors: Zbukvic Isabel , Nicholas Jennifer , Hamilton Craig , Cruz-Manrique Paula , Crlenjak Caroline , Purcell Rosemary 
Published: September 2022

AbstractGlobally, mental illness and substance use disorders are the leading cause of disability and disease burden for young people. Orygen is an Australian youth mental health organisation with a mission to reduce the impact of mental ill health on young people, families and society, through research, clinical services, advocacy, and the design and delivery of youth mental health workforce and service development initiatives. Orygen is one of only a few known research and clinical centres with a dedicated knowledge translation division, which concentrates on growing the capacity of the systems, services, and professionals who support young people experiencing mental ill health. This paper provides a case study of the workforce development team within the Orygen knowledge translation, outlining how implementation science informs their work and how the division has adapted its model in the face of COVID-19. Since 2017, the team has delivered training to more than 4000 youth mental health workers across Australia, on the topics of trauma, psychosis, mood and anxiety disorders, brief interventions, cognition and other areas of youth mental health. The COVID-19 pandemic generated abrupt and dramatic changes to the delivery of workforce and service development initiatives in Australia due to significant restrictions to travel and in-person events. It also placed major delivery demands on youth mental health services. This paper outlines how the team at Orygen adapted their approach to youth mental health workforce development in response to COVID-19, offering reflections and future directions for implementation science that can support flexible models of support in a changing system.
Clinicopathological Correlations in Enucleated Globes of Late-Stage Coats Disease with a Review of the Literature
Authors: Helmi Hala A. , Jammah Abdullah , Maktabi Azza MY. , AlMesfer Saleh , Alkatan Hind M. 
Published: September 2022

Abstract
Background
Coats disease may cause diagnostic dilemma because of its variable clinical presentation that can be suspicious of retinoblastoma. Late sequelae of the disease are blinding with possible enucleation. We demonstrate the main histopathological findings of Coats enucleated eyes with literature review.

Methods
This was a retrospective study of all enucleated globes diagnosed as Coats disease over 30 years and were reviewed by two pathologists. The corresponding demographic data, clinical presentation, pre-operative clinical impression, and indication for enucleation were collected. Descriptive analysis of our own series data was performed. Our findings were then correlated to published data that were collected from 1983 to 2021 from the PUBMED database in English-written language. Shields classification was used as an inclusion criterion for the published reports to be analyzed.

Results
We had seven enucleated globes with Coats disease. Mean age at presentation was 3.2 years (range 3 months to 9 years). Male predominance was observed in 6 and all cases were unilateral. Strabismus was the most common initial presentation (57%, n = 4), followed by leukocoria (43%, n = 3). Indication for enucleation was mostly suspected retinoblastoma (57%, n = 4). Four eyes were classified as stage 4, and 2 had advanced stage 5 changes. Histopathologically, subretinal fluid with lipid-laden macrophages was seen in all cases, the anterior chamber was shallow in 5/7 with angle neovascularization in 2/7. Telangiectatic vessels were clearly observed in 4/7.

Conclusion
Coats disease is a potentially visually disabling disease that is mostly unilateral in 95%, has male predominance of 81%, and wide age range with a mean of 17 years. In Saudi Arabia, the disease seems to present at younger age, tends to be more advanced, and may be indistinguishable from retinoblastoma at the time of diagnosis. Shields staging of Coats is highly recommended to be followed clinically to unify the pathways for treatment and to correlate the concluded outcomes.
Comics as a body image intervention among adolescents in Indian Hindi medium schools: insights from an acceptability study
Authors: Ahuja L. , Hasan F. , Diedrichs P. C. , Lewis-Smith H. 
Published: September 2022

AbstractBackgroundIndian adolescents experience body dissatisfaction. However, empirically supported interventions are lacking, particularly in lower socio-economic regions of India. This paper describes the acceptability testing of a six-session teacher-led comics-based intervention, aiming to improve body image and related outcomes among adolescents in Indian Hindi medium schools.MethodsThirty-five students (50% girls; Mage, girls = 12.3 years; Mage, boys = 13 years) and nine teachers (11% women) from Hindi medium schools in Rajasthan, India, completed a quantitative acceptability questionnaire regarding comics that target body dissatisfaction and associated risk factors. They also participated in online or telephone semi-structured interviews to share in-depth feedback, with teachers providing additional feedback on an accompanying teacher guide. The quantitative data were analysed descriptively, with the interviews analysed using qualitative codebook thematic analysis.ResultsQuantitative analyses revealed that 73% of students felt the comics made them feel good about themselves. Qualitative analyses revealed four themes: (1) body dissatisfaction is a concern; (2) the comics are powerful; (3) increasing ease of understanding; (4) a teacher guide to aid delivery.ConclusionThis study demonstrates acceptability of a novel teacher-led comics-based body image intervention for adolescents in Indian Hindi medium schools from lower socio-economic settings. These findings are currently informing intervention optimizations, which will be evaluated in a randomized controlled effectiveness trial. If found to be effective, this intervention will be disseminated across eight Indian states by UNICEF. Trial registration. This trial has been registered with ClinicalTrials.gov; a database of privately and publicly funded studies conducted around the world. Registration date: 2nd May 2020; Registration ID: (NCT04317755). https://clinicaltrials.gov/ct2/show/NCT04317755?term=NCT04317755&draw=2&rank=1.
Coffee consumption and skeletal muscle mass: WASEDA’S Health Study
Authors: Kawakami Ryoko , Tanisawa Kumpei , Ito Tomoko , Usui Chiyoko , Ishii Kaori , Muraoka Isao , Suzuki Katsuhiko , Sakamoto Shizuo , Higuchi Mitsuru , Oka Koichiro 
Published: September 2022

AbstractFew studies have examined the association between coffee consumption and muscle mass; their results are conflicting. Therefore, we examined the association between coffee consumption and low muscle mass prevalence. We also performed an exploratory investigation of the potential effect modification by demographic, health status-related and physical activity-related covariates. This cross-sectional study included 2085 adults aged 40–87 years. The frequency of coffee consumption was assessed using a self-administered questionnaire. Muscle mass was assessed as appendicular skeletal muscle mass/height2 using a multifrequency bioelectrical impedance analyser. We defined low muscle mass using cut-offs recommended by the Asian Working Group for Sarcopenia. Multivariable-adjusted OR for low muscle mass prevalence were estimated using a logistic regression model. The prevalence of low muscle mass was 5·4 % (n 113). Compared with the lowest coffee consumption group (< 1 cup/week), the multivariable-adjusted OR (95 % CI) of low muscle mass prevalence were 0·62 (0·30, 1·29) for 1–3 cups/week, 0·53 (0·29, 0·96) for 4–6 cups/week or 1 cup/d and 0·28 (0·15, 0·53) for ≥ 2 cups/d (P for trend < 0·001). There were no significant interactions among the various covariates after Bonferroni correction. In conclusion, coffee consumption may be inversely associated with low muscle mass prevalence.
MUSIC COMPOSITION AND EPISTEMIC INJUSTICE
Authors: Redhead Lauren 
Published: September 2022

AbstractThis article considers the implications of the consideration of epistemic justice within modes of composition pedagogy in higher education and is in part a manifesto, in part a reflection on my experiences of teaching composition in this setting. I ask how composition education can become, as described in 2015 by the North Macedonian dramatist and creative educator Goran Stefanovski, ‘the politics of the impossible’. I question how composition education could function without a canon of examples or assumed master–apprentice hierarchies and frame this as a question of epistemic justice, one that considers the composers themselves as individuals prior to the technical exercises that they may undertake. I describe why I believe that epistemic justice is a concept that is worthy of consideration in creative education in composition alongside the ways that current models of composition pedagogy might unintentionally cause students to experience epistemic injustice within their education experiences. Rather than a prescriptive model, I propose challenges that I hope can influence my educational approach now and in the future and conclude with some suggestions about what a model of hermeneutic epistemic justice might look like as a pedagogic model for music composition.
Making life and mind as clear as possible, but not clearer
Authors: Gomez-Marin Alex 
Published: September 2022

Abstract
Neuroscience needs theory. Ideas without data are blind, and yet mechanisms without concepts are empty. Friston's free energy principle paradigmatically illustrates the power and pitfalls of current theoretical biology. Mighty metaphors, turned into mathematical models, can become mindless metaphysics. Then, seeking to understand everything in principle, we may explain nothing in practice. Life can't live in a map.
Blankets, heat, and why free energy has not illuminated the workings of the brain
Authors: Spector Donald , Graham Daniel 
Published: September 2022

Abstract
What can we hope to learn about brains from the free energy principle? In adopting the “primordial soup” physical model, Bruineberg et al. perpetuate the unsupported notion that the free-energy principle has a meaningful physical – and neuronal – interpretation. We examine how minimization of free energy arises in physical contexts, and what this can and cannot tell us about brains.
Markov blankets: Realism and our ontological commitments
Authors: Williams Danielle J. 
Published: September 2022

Abstract
The authors argue that their target is orthogonal to the realism and instrumentalist debate. I argue that it is born directly from it. While the distinction is helpful in illuminating how some ontological commitments demand a theory of implementation, it's less clear whether different views cleanly map onto the epistemic and metaphysical uses defined in the paper.
Nothing but a useful tool? (F)utility and the free-energy principle
Authors: Colombo Matteo 
Published: September 2022

Abstract
Bruineberg and collaborators distinguish three philosophical positions about the status of Markov blankets in the context of active inference modelling, namely: literalism, realism, and instrumentalism. They criticize the first two positions and suggest that instrumentalism is “less problematic but also less interesting” (sect. 6.1.2, para. 5) Here, I sketch how literalists and realists might reply to Bruineberg et al.'s criticisms, and I explain why instrumentalism is more interesting and contentious than what Bruineberg and collaborators suggest.
Markov blankets and the preformationist assumption
Authors: Dengsø Mads , Robertson Ian , Constant Axel 
Published: September 2022

Abstract
Bruineberg and colleagues argue that a realist interpretation of Markov blankets inadvertently relies upon unfounded assumptions. However, insofar as their diagnosis is accurate, their prescribed instrumentalism may ultimately prove insufficient as a complete remedy. Drawing upon a process-based perspective on living systems, we suggest a potential way to avoid some of the assumptions behind problems described by Bruineberg and colleagues.
The Partition of India, Bengali “New Jews,” and Refugee Democracy: Transnational Horizons of Indian Refugee Political Discourse
Authors: Banerjee Milinda 
Published: September 2022

AbstractThis essay advocates “refugee political thought” as an autonomous category which needs to be centre-staged in global intellectual history. I concretise this by studying Bengali Hindu refugees who migrated from Muslim-majority eastern Bengal (after the Partition of British India in 1947 part of Pakistan, and after 1971, the sovereign state of Bangladesh) to the Hindu-majority Indian state of West Bengal, and occasionally their descendants as well. By studying the transnational horizons of Bengali refugees from the late 1940s to today, I posit them as part of modern global intellectual history. Bengali refugees and their descendants connected their experiences with those of refugees elsewhere in the world, seeing themselves, for example, as “new Jews.” Later, some of them aligned themselves with the Palestinian cause. Refugee politics became enmeshed with Cold War revolutionary currents. European, Soviet, and Chinese Marxist theory—and latent Lockean assumptions—propelled the everyday politics of refugee land occupation. Marxism, sometimes with Hegelian inflection, nourished the East Bengali-–origin founders of Subaltern Studies theory and Dalit (lower-caste) thought. Ultimately, this essay shows how Bengali refugees instrumentalised transnational thinking to produce new models of democratic political thought and practice in postcolonial India. I describe this as “refugee democracy.”
Regulation of the Respiration Quotient Across Ocean Basins
Authors: Moreno Allison R. , Larkin Alyse A. , Lee Jenna A. , Gerace Skylar D. , Tarran Glen A. , Martiny Adam C. 
Published: September 2022

AbstractA key uncertainty for predicting future ocean oxygen levels is the response and feedback of organic matter respiration demand. One poorly constrained component of the respiration demand is the oxygen‐to‐carbon remineralization ratio—the respiration quotient. Currently, multiple biological hypotheses can explain variation in the respiration quotient of organic matter produced in the surface ocean. To test these hypotheses, we directly quantified the particulate respiration quotient in 715 samples along a meridional section of the Atlantic Ocean and compared to previous Pacific Ocean observations. We demonstrate significant regional shifts in the respiration quotient and a two‐basin average of 1.16. Possible diel oscillations were also observed in the respiration quotient. Basin and regional variation in the respiration quotient were positively linked to temperature, N versus P stress, and plankton size structure. These observations suggest a complex regulation of the respiration quotient with important implications for the regional coupling of carbon and oxygen cycling.