bluuebunny/crossref_metadata_2025_split huggingface dataset:
Based on the proteomics method to explore the relative differential protein expression of carbon tetrachloride-induced acute liver injury in mice
Authors: Li Weihua , Lei Yanli , Jin Xueqin , Wang Zhisheng , Lu Xiaoli , Yang Li , Wu Jing 
Published: July 2022

Abstract
Background
CCL4 as a chemical inducer,which can induce multiple organ damage, especially acute liver injury,but the related mechanism of its damage has not been systematically reported.
Methods
In this study, we exposed BALB/c mice for 8 weeks, and found significant inflammatory damage and dysfunction to the liver in blood biochemical indicators and histopathological observations. Using tandem mass tag (TMT) marker proteomic analysis identified 395 proteins that were significantly altered in the liver,as indicated by Gene Ontology (GO) annotation,KEGG pathway and protein-protein interaction (PPI) network analysis more significant proteins.
Results
We found that distinctly enriched differential proteins play important roles in gene expressionin terms of protein expression difference multiples, biomarker application and participation in classical signal pathway (JAK-STAT signaling pathway,PI3K-Akt signaling pathway,Rap1 signaling pathway,PPAR signaling pathway,GnRH signaling pathway,AGE-RAGE signaling pathway). There are significant enrichment for differential proteins in classical signal pathway, and the enrichment was relatively high. These pathways mainly included in the body's immunity,cell division,apoptosis and autophagy, inflammation and tumor formation,and also mediate the expression level of related proteins in MAPK/ERK signaling pathway,NF-КB signaling pathway and TGF-β signaling pathway.
Conclusions
Using proteomics methods to explore the possible pathways of CCl4 inducing acute liver injury. On the one hand, Multi-directional and multi-target exploration will reveal the toxic mechanism of chemical toxins on liver injury in a deeper level, and on the other hand, it will enrich the relevant research database.At the same time, it also provides a new direction and basis for the further development of liver-protecting targeted drugs.
Strain tuning of negative capacitance in ferroelectric KNbO3 thin films
Authors: Luo Yongjian , Chen Deyang , Wang Zhen , Chen Yu , Qin minghui , Fan Zhen , Zeng Min , Zhou Guofu , Lu Xubing , Gao Xingsen , Liu Jun-Ming 
Published: July 2022

Abstract
Ferroelectrics with negative capacitance effect can amplify the gate voltage in field-effect transistors to achieve low power operation beyond the limits of the Boltzmann's Tyranny. The reduction of power consumption depends on the capacitance matching between the ferroelectric layer and gate dielectrics, which can be well controlled by adjusting the negative capacitance effect in the ferroelectrics. However, it is a great challenge to experimentally tune the negative capacitance effect. Here, the observation of tunable negative capacitance effect in ferroelectric KNbO3 through strain engineering is demonstrated. The magnitude of the voltage reduction and negative slope in polarization-electric field (P-E) curves as the symbol of negative capacitance effect can be controlled by imposing various epitaxial compressive strain. The expansion of negative curvature region in polarization-energy landscape under compressive strain is responsible for the tunable negative capacitance. Our work paves the way for fabricating low power devices and further reducing energy consumption in electronics.
Lower leg blood pressure decreases while calf external pressure increases with the angulation of the Trendelenburg position in the lithotomy position with calf- and foot-supported leg holders
Authors: Mizuno Ju , Iijima Satomi , Takahashi Toru 
Published: July 2022

Abstract
Objective
Patients who underwent lower abdominopelvic surgeries in the lithotomy position (LP) and the Trendelenburg position (TP) with the leg holder are at risk of developing well leg compartment syndrome (WLCS). However, contributing factors related to the LP with TP associated with WLCS are unknown. This study aimed to investigate the associations between external pressure at the calf in the LPs at different angulations of the TP and physiological characteristics.
Methods
Eighty-four university students (age, 21.7 ± 0.9; 42 men and 42 women) voluntarily participated in the study. The awake participants were placed in the LPs using the calf- and foot-supported leg holder at 0° (horizontal level), 5°, 10°, and 20° head-down tilts by moving the electric operating table. The peak contact pressure (pCP) was measured at the calf as a representative external pressure using the pressure distribution measurement system BIG-MAT®.
Results
Lower leg blood pressure significantly decreased with TP angulation, while calf pCP significantly increased with it at 0°, 5°, 10°, and 20° head-down tilts (39.4 ± 15.2, 46.5 ± 17.7, 47.2 ± 16.9, and 50.3 ± 17.6 mmHg, respectively). The calf pCP with a 10° head-down tilt was correlated positively with the calf total force (P < 0.001) and negatively with the calf contact area (P < 0.001).
Conclusion
Blood hypoperfusion due to low lower leg blood pressure secondary to lower leg elevation and head-down tilt, and high calf external pressure due to direct external compression from the leg holder where it is loaded may contribute to WLCS.
Assessment of the land use classification surrounding a dam in the semi arid of Pernamuco/Brazil from OLI, MUX images and WorldCover data
Authors: Júnior Juarez Antônio da Silva , Pacheco Admilson da Penha 
Published: July 2022

Abstract
Detecting changes in land cover helps policymakers to understand the dynamics of environmental changes to ensure sustainable development in the Caatinga Biome. Thus, the identification of spatial features by Remote Sensing emerged as an important research aspect and, therefore, an adequate and accurate methodology for land cover mapping was necessary. In this study, Landsat-8 and CBERS-4 satellite data captured by the Operational Land Instrument (OLI) and the Regular Multispectral Camera (MUX) were used for classification and accuracy analysis for six land cover classes around the dam ‘Barra do Juá’, located in the semi-arid region of Pernambuco state. Recent high resolution images from the European program WorldCover were used as spatial and thematic reference images. The approach developed provided land cover maps for each dataset. After the comparative analysis with the reference product, an accuracy of the producer and average user of 62.44% and 71.74% for MUX and 60.88% and 62.38% for OLI were obtained, respectively. Spatial and spectral characteristics of the images were the main causes of the variability found in the thematic accuracy coefficients. The results obtained showed that the CBERS-4 MUX presented more satisfactory land cover maps than the Landsat-8 OLI data. However, for the classes of natural vegetation, OLI presented better results than MUX.
Forensic analysis of novel SARS2r-CoV identified in game animal datasets in China shows evolutionary relationship to Pangolin GX CoV clade and apparent genetic experimentation
Authors: Jones Adrian , Massey Steven E , Zhang Daoyu , Deigin Yuri , Quay Steven C. 
Published: July 2022

Abstract
Pangolins are the only animals other than bats proposed to have been infected with SARS-CoV-2 related coronaviruses (SARS2r-CoVs) prior to the COVID-19 pandemic. Here we examine the novel SARS2r-CoV we previously identified in game animal metatranscriptomic datasets sequenced by He et al. (2022) and find that sections of the partial genome phylogenetically group with Guangxi (GX) pangolin CoVs (GX PCoVs) while the full RdRp sequence groups with bat-SL-CoVZC45. While the novel SARS2r-CoV is found in 6 pangolin datasets, the same CoV is also found in 10 additional NGS datasets from 5 separate mammalian species and is likely related to contamination by a laboratory researched virus. We find that NGS datasets containing the novel SARS2r-CoV are contaminated with significant Homo sapiens genetic material, and numerous viruses not associated with the host animals sampled. We further identify the dominant human haplogroup of the contaminating H.sapiens genetic material to be F1c1a1, which is of East Asian provenance. The association of this novel CoV with both bat CoV and the Guangxi pangolin CoV (GX PCoV) clades is an important step towards identifying the origin of the GX PCoVs.
A closer look at Self Esteem and Perceived Social Support: Their role in Depression among Women with Chronic Illnesses
Authors: Bano Nasreen , Shahzad Salman , Ahmad Shafaq 
Published: July 2022

Abstract
Chronic illnesses not only bring physical strains but also affect one's psychological health. Long-term treatments and variations in severity demand psychological resources to cope up with these illnesses. Cancer and heart diseases are among those illnesses which are quite prevalent and tax one’s resources to fight with illnesses. A cross sectional study design was used to carry out this study which aims to find the predictive association of depression with self-esteem and perceived social support among women with chronic illness (breast cancer and angina). A sample of 102 women diagnosed with breast cancer (51) and Angina (51) with the age ranges between 30-60 years (Mean age = 47.6, SD=10.68), were taken. They were recruited from different hospitals including Sindh Government Hospital, Dar-ul-Sukoon and Dow university Hospital Karachi, Pakistan using purposive sampling technique. Patients’ Health Questionaire-9, Rosenberg Self-Esteem, and Multidimensional Perceived Social Support was administered. Findings show that self-esteem has contributed to lowering depression in women diagnosed with cardiac illness (Angina) as well as cancer (breast Cancer).Perceived social support has a significant effect on depression in women with cardiac illness (Angina) however it has a non-significant contribution in the reduction of depression in women with cancer (breast cancer).
Gravitational folding of surface tension regions originates bio quantum path duality that quantizes Newtonian rigid inertia into parameter trigonometric inversion topological bio inertia
Authors: Lai Yi Yu 
Published: July 2022

Abstract
Universal interaction reference systems in nature can’t avoid elastic inversion(memory). Newton established the parameter quantity-driving rigid reference system with zero system inversion. Bio-systems fall to another extremity that can only utilize inversion energy with almost zero rigidness. We define inversion energy as parameter-against-gravity-internal-fluctuation, write down modifications of Newtonian three Laws as, first law: 𝑑𝑑𝑥cosx =−𝑠𝑖𝑛𝑥, 𝑑𝑑𝑥sinx = 𝑐𝑜𝑠𝑥; second law: 𝐹⃗=𝑚∙𝑎⃗ + |𝑚𝑔⃗∫𝑡𝑔𝜃⋅𝑑𝜃 ⟩↿⇂; third law: Wavelength = 2𝑛L, frequency = n𝑓0 . The Schrödinger equation has only quantized energy but still hasn’t quantized time thus inducing quantum collapse. We then conjugate inversion energy with quantizing time which composes of event inversion superposition to establish entropy-control lifespan for bio-systems. Originated from the gravitational folding of surface tension regions, bio quantum path duality fluctuation scales as macrocosmic elastic quantum ranges from a codon to the spinal size drives life evolution. The driving dynamics of biological functions including consciousness revive from the bio quantum path duality that modulates by the three modified laws.
Concept analysis of professionalism in teachers and faculty members
Authors: Shokri Taiebe , Yazdani Shahram , Ahmadi Soleiman , Afshar Leila 
Published: July 2022

Objectives: Considering the important role of medical education teachers to prepare teachers and students in the future, the need to determine the concept of professional teacher and teacher and the characteristics of teacher professionalism, we have explained the concept of professionalism in teachers in this study.
Methods: The concept analysis method used in this research was Walker and Avant method which has eight steps. Walker and Avant state the purpose of concept analysis as follows: The process of distinguishing between the defining features of a concept and its unrelated features. The process of concept analysis includes selecting a concept, determining the purpose of the analysis, identifying the uses of the concept, determining the defining features of the concept, identifying a model, identifying boundary and adversarial items, identifying the precedents and consequences of the concept, and defining empirical references. Is
Results: Professionalism in its general sense, requires deep knowledge, insight, creating a healthy and safe environment, honesty and trust, impartiality, commitment to the profession and continuous improvement, punctuality, criticism, professional competence, responsibility and individual accountability, especially In social interactions, there is an effort for continuous improvement that the acquisition of these characteristics is not easily possible and requires education, especially continuous learning. Professionalism is a set of values, behaviors and relationships that underpin public trust in teachers.
Conclusion: The most important application of this analysis is the concept of basing the definition provided in order to objectively and realistically evaluate the professionalism of professors and strive to improve and enhance it.
Evaluation of DNA Damage in Traffic Cops Exposed to Polycyclic Aromatic Hydrocarbon Pollution in Baghdad City Streets and its Association to Certain Biomarkers
Authors: R. Salem Ashraf , A.R. Al-Wasiti Estabraq , A. Hasan Fahem 
Published: July 2022

Objectives: To find out the extent to which the genetic material of Baghdad traffic policemen is affected by the oxidative damage caused by pollutants by monitoring the levels of 8-OHdG compared to the levels of antioxidant enzymes and malondialdehyde.
Methods: This study includes 140 participants; they have been divided into two groups (traffic police and office police). Polycyclic aromatic hydrocarbons were analyzed for each participant by GC/FID while 8-OHdG and antioxidant enzymes were measured by the ELISA technique.
Results: The levels of polycyclic aromatic hydrocarbons, 8-Oxo-dG, and malondialdehyde were elevated in the blood of the traffic police compared to the office police, while higher levels of antioxidant enzymes (Catalase and glutathione peroxidase) were observed in the blood of the office police.
Conclusion: Exposure to polycyclic aromatic hydrocarbones can cause oxidative stress through their metabolic derivatives and the resulting active molecules, which lead to the formation of 8-Oxo-dG and the reduction of enzymatic antioxidants, which may lead to the emergence of cancers.
Association between Variant Alleles of the X-Ray Cross Complementing Gene (XRCC1) with Benzo[a]Pyrene Levels in Iraqi Workers
Authors: R. Omrain Alaa , A.R. Al-Wasiti Estabraq , Jassim Hamzah Mohammed 
Published: July 2022

Objectives: Assessment of a single nucleotide polymorphism of the XRCC1 (codon Arg399Gln) gene and its association with levels of benzo[a]pyrene in blood of car repairers and control group.
Methods: The current study included (111) participants, (37) of the iraqi car repairers, (37) sellers of spare part, and (37) healthy (controll), with the same age range. benzo[a]pyrene was determined by using HPLC technique. Alleles frequency of singl nucleotide polymorphisms of XRCC1 gene was determined by Restriction fragment length polymorphisms (PCR-RFLP).
Results: The results of current study indicated that there is a highly significant increase of B[a]P level (p= 0.0001) in the repairers group compared to the groups of spare part sellers and control together. The genotype frequencies studies of XRCC1 gene of car repairers group and controls. The effect of rs25487 genotypes on exposure to PAHs include higher levels of PAHs and PAH-DNA adduct in TT genotype followed by CT genotype and CC showed lower levels.
Conclusions: As results of prolonged exposure to the higher levels of PAHs that Iraqi car repaiers suffer from, they have highe levels B[a]P. especially those who have the TT genotypes, as results of the inefficiency of thier DNA repair system. Compared to the other genotypes.
Pembuatan minuman tradisional loloh daun belimbing wuluh sebagai atraksi wisata kuliner alternatif di desa beraban, tabanan – bali
Authors: Widuri Setyowati ayu , Arismayanti Ni Ketut 
Published: July 2022

Saat ini perkembangan wisata kuliner di Bali sudah mulai banyak di lirik dan menjadi salah satu tujuan orang berwisata ke Bali. Kuliner tradisional Bali selama ini yang terkenal adalah jenis makanan sedangkan untuk minuman belum begitu di ketahui oleh wisatawan padahal minuman tradisional Bali sangat banyak jenis dan ragamnya. Salah satu minuman tradisional Bali adalah Loloh.
Loloh adalah ramuan herbal khas Bali yang bermanfaat bagi kesehatan dan juga sebagai minuman segar pelepas dahaga. Salah satu loloh yang memiliki khasiat kesehatan dan juga melepas dahaga adalah loloh daun belimbing wuluh, daerah penghasil loloh daun belimbing wuluh dengan pengolahan tradisional di Bali berada di Kabupaten Tabanan tepatnya di Desa Beraban, Kecamatan Selemadeg Timur, Kabupaten Tabanan.
Metode pengumpulan data dalam penelitian ini adalah dengan melakukan obsevasi, wawancara mendalam dan studi kepustakaan. Sedangkan teknik pengumpulan data yang di gunakan dalam penelitian kualitatif berupa teknik perekaman dengan kamera. Penentuan informan dalam penelitian ini dilakukan secara purposive yaitu informan terpercaya. Informan dalam penelitian ini adalah pembuat loloh belimbing wuluh di Desa Beraban, Kecamatan Selemadeg Timur, Kabupaten Tabanan. Teknik analisis data yang di pakai dalam penelitian ini adalah deskriftif kualitatif
Proses pengolahan loloh daun belimbing wuluh ini bisa di jadikan atraksi kuliner alternative di desa Beraban, Tabanan – Bali dengan keunggulan proses pengolahan yang masih di lakukan secara tradisional dan memiliki rasa yang khas serta bermanfaat untuk tubuh. Loloh daun belimbing wuluh ini bisa di promosikan pada wisatawan yang berkunjung ke desa Beraban Tabanan – Bali sebagai salah satu alternative atraksi wisata kuliner yang akan sangat bermanfaat bagi perekonomian masyarakat setempat.
Kata kunci : minuman tradisional, loloh, bali
Analisis good corporate governance pada pengadaan bahan makanan di fame hotel sunset road bali
Authors: Sudarsana I Ketut , Dewi Ni Kadek Shinta 
Published: July 2022

Kelancaran aktivitas operasional Fame Hotel Sunset Road Bali merupakan hal penting yang dapat mempengaruhi peningkatan kepuasan tamu, oleh karena itu hotel harus memiliki kesanggupan untuk menyediakan segala kebutuhan tamu. Pengadaan bahan makanan memegang peran penting dalam menyediakan bahan dan kebutuhan operasional hotel. Manajemen harus mampu memilih supplier yang dapat bekerjasama dalam memenuhi kebutuhan operasional hotel sesuai dengan standar yang telah ditetapkan oleh hotel. Rumusan masalah dari penelitian ini adalah bagaimanakah penerapan good corporate governance pada pengadaan bahan makanan di Fame Hotel Sunset Road Bali dan dengan tujuan untuk mengetahui penerapan good corporate governance pada pengadaan bahan makanan di Fame Hotel Sunset Road Bali. Teknik analisis data yang digunakan dalam penelitian ini adalah deskriptif kualitatif yang diperoleh dari wawancara, observasi, dan dokumentasi. Penelitian ini ditunjang dengan lima prinsip dari praktik Good Corporate Governance yang diatur dengan Keputusan Menteri BUMN Kep-117/M-MBU/2002 bab II pasal 3 yakni transparansi, akuntabilitas, pertanggungjawaban, kemandirian, dan kewajaran. Hasil penelitian menunjukkan bahwa penerapan good corporate governance pada pengadaan bahan makanan di Fame Hotel Sunset Road Bali belum berjalan dengan baik. Pembelian bahan makanan belum berdasarkan standard purchase specification. Bagian penerimaan dalam menerima bahan makanan hanya melihat kualitas bahan makanan dari tampilan luar saja. Penataan dan penempatan bahan makanan digudang belum sesuai dengan tata kelola penyimpanan dan metode first in first out saat pengeluaran tidak diterapkan.
Formulation And Invitro, In Vivo Evaluation Of Mucoadhesive Buccal Tablet Of Enalapril Maleate
Authors: Joan vijetha R  , Balamurugan K  
Published: July 2022

The buccal area of the mouth mucosal cavity provides an adorable route of administration for systemic and local medication distribution. Among the several transmucosal locations accessible, the mucosa of the buccal cavity was determined to be the most convenient and easily approachable site for the administration of therapeutic drugs as retentive dose forms delivery. The objective of the current research is based on to improve the bioavailability and efficacy of the Enalapril maleate (EM) a commonly used antihypertensive drug through buccal mucosal. The pure drug EM and excipient polymers such as, hydroxypropyl methylcellulose (HPMC K100), Carbopol 934p, Chitosan and polyvinyl pyrrolidone (PVP K30) were obtained from manufacturing industries. EM buccal tablets were prepared using direct compression. The powder blend formulation studies such as Bulk density, tapped density, Hausner ratio, Carr’s index and angle of repose were carried out, moisture absorption study was performed by using 5%W/V agar, residence time was carried out using porcine buccal mucosa, ex vivo permeation was performed using Franz diffusion cell and in vivo drug release for API and formulated tablets were studies using rabbits. The result of our study showed that the powder flow properties were found to be within the limits, moisture absorption study was 67.63%, residence time till 8.15 hrs, ex vivo permeation 99.12% and in vivo drug release was extended till 24 hrs. The bioregion in which it will remain in contact were perfectly done with appropriate evaluation techniques (Residence time), the moisture absorption study was carried out to check how much moisture the tablet can absorbed to release the drug and was found satisfactory. The ex vivo permeation study was performed by Franz diffusion cell to check the drug permeation through buccal mucosa. The in vivo studies were performed on New Zealand rabbits and can be concluded that the drug release from the formulated F6 was better than the marketed API.
Density Functional Studies on the excited states and active sites of sulforaphane
Authors: Wu ShiQuan , Lu Li-Min , Li Li , Liang QiQi , Gao HuaXu , Zhao Xian-Hao , Hu De-Yuan , Tang Tian-Yu , Tang Yan-Lin 
Published: July 2022

Sulforaphane is the plant active substance with the best anticancer
effect and antioxidant found in vegetables. In this paper, based on
density functional theory(DFT), the B3LYP/6-311G+(d,p) theoretical level
was used to optimize the molecular structure of sulforaphane in gas
phase. On the basis of optimization, the first 30 excited states of
molecule in methanol were calculated by time-density functional
theory(TD-DFT) in SMD solvent model. To analy the excited states of
sulforaphane molecule by calculate UV spectrum and hole-electron.
Finally, we predicted the active sites of sulforaphane molecule by
calculating frontier orbital and fukui function. The results show
that: In the UV spectrum, the absorption peaks at 204.4602 and
336.5590nm are the absorption bands of hetero atomic groups of conjugate
molecules, which are generated by n-π* transition and belong to R
absorption band. According to hole-electron analysis, S0→S18 is the
local excitation, and S0→S7, S0→S25 and S0→S29 are the charge transfer
excitation. In addition, the O and S atoms on sulfuryl group of
sulforaphane are the site of electrophilic reaction; the C and S atoms
on the cyanide group are sites of nucleophilic reaction. This study
provides a theoretical basis for better understanding the antioxidant
and anticancer mechanisms of sulforaphane.