bluuebunny/crossref_metadata_2025_split huggingface dataset:
Migration Studies with a Compositional Data Approach: A Case Study of Population Structure in the Capital Region of Denmark
Authors: Elío Javier , Georgati Marina , Hansen Henning S. , Keßler Carsten 
Published: July 2022

AbstractComputing percentages or proportions for removing the influence of population density has recently gained popularity, as it offers a deep insight into compositional variability. However, data are constrained to a constant sum and therefore are not independent observations, a fundamental limitation for applying standard multivariate statistical tools. Compositional Data (CoDa) techniques address the issue of standard statistical tools being insufficient for the analysis of closed data (i.e., spurious correlations, predictions outside the range, and sub-compositional incoherence) but they are not widely used in the field of population geography. Hence, in this article, we present a case study where we analyse at parish level the spatial distribution of Danes, Western migrants and non-Western migrants in the Capital region of Denmark. By applying CoDa techniques, we have been able to identify the spatial population segregation in the area and we have recognised patterns in the distribution of various demographic groups that can be used for interpreting housing prices variations. Our exercise is a basic example of the potentials of CoDa techniques which generate more robust and reliable results than standard statistical procedures in order to interpret the relations among various demographic groups. It can be further generalised to other population datasets with more complex structures.
Stellungnahme zu Acetaldehyd als Aromastoff: Aspekte der Risikobewertung
Authors: Hengstler Jan G. , Baum Matthias , Cartus Alexander T. , Diel Patrick , Eisenbrand Gerhard , Engel Karl-Heinz , Engeli Barbara , Epe Bernd , Grune Tilman , Guth Sabine , Haller Dirk , Heinz Volker , Hellwig Michael , Henle Thomas , Humpf Hans-Ulrich , Jäger Henry , Joost Hans-Georg , Kulling Sabine E. , Lachenmeier Dirk W. , Lampen Alfonso , Leist Marcel , Mally Angela , Marko Doris , Nöthlings Ute , Röhrdanz Elke , Roth Angelika , Spranger Joachim , Stadler Richard , Steinberg Pablo , Vieths Stefan , Wätjen Wim 
Published: July 2022

AbstractOpinion on acetaldehyde as a flavouring substance: considerations for risk assessmentAcetaldehyde occurs naturally in many foods and is also used as a flavouring due to its fruity aroma. The International Agency for Research on Cancer (IARC) classified acetaldehyde as possibly carcinogenic to humans and, in combination with oral intake via alcoholic beverages, as carcinogenic to humans. Therefore, the question arises whether the use of acetaldehyde as a flavouring agent is still justifiable. The Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG) reviewed the scientific basis for health risk assessment of the use of acetaldehyde as a flavouring substance and adopted an opinion. Based on the available data, it is at present not possible to conclude if acetaldehyde is genotoxic and mutagenic in vivo after oral exposure. There is also uncertainty regarding the contribution of acetaldehyde as a flavouring substance to the overall exposure to acetaldehyde. Therefore, a science-based assessment on health risk related to the use of acetaldehyde as a flavouring is not possible at present. Considering the genotoxic potential as well as numerous data gaps that need to be closed for a full risk assessment, the SKLM is concerned about the safety of acetaldehyde as a flavouring substance. For reasons of precautionary consumer protection, the SKLM considers that the use of acetaldehyde as a food additive should be re-evaluated.
Moxifloxacin rescues SMA phenotypes in patient-derived cells and animal model
Authors: Januel Camille , Menduti Giovanna , Mamchaoui Kamel , Martinat Cecile , Artero Ruben , Konieczny Piotr , Boido Marina 
Published: July 2022

AbstractSpinal muscular atrophy (SMA) is a genetic disease resulting in the loss of α-motoneurons followed by muscle atrophy. It is caused by knock-out mutations in thesurvival of motor neuron 1(SMN1) gene, which has an unaffected, but due to preferential exon 7 skipping, only partially functional human-specificSMN2copy. We previously described aDrosophila-based screening of FDA-approved drugs that led us to discover moxifloxacin. We showed its positive effect on theSMN2exon 7 splicing in SMA patient-derived skin cells and its ability to increase the SMN protein level. Here, we focus on moxifloxacin's therapeutic potential in additional SMA cellular and animal models. We demonstrate that moxifloxacin rescues the SMA-related molecular and phenotypical defects in muscle cells and motoneurons by improving theSMN2splicing. The consequent increase of SMN levels was higher than in case of risdiplam, a potent exon 7 splicing modifier, and exceeded the threshold necessary for a survival improvement. We also demonstrate that daily subcutaneous injections of moxifloxacin in a severe SMA murine model reduces its characteristic neuroinflammation and increases the SMN levels in various tissues, leading to improved motor skills and extended lifespan. We show that moxifloxacin, originally used as an antibiotic, can be potentially repositioned for the SMA treatment.
Control design of a reciprocating high-speed wire feed system for 7-axis robotic electric discharge machining
Authors: Almeida Sergio , Mo John , Ding Songlin , Bil Cees 
Published: July 2022

AbstractFor decades, researchers have struggled to solve 6-axis robotic vibration while machining hard-to-cut materials. On the other hand, wire electric discharge machining (WEDM) stands out as a non-conventional machining process able to cut large and complex profiles of any conductive hard-to-cut material with minor non-contact forces. Thus, WEDM is a promising process to be combined into a robot to overcome vibration and low accuracy. However, the robot characteristics of a high degree of freedom combined with payload limitation oblige to separate the heavy wire winding system from the robot end-effector, demanding an equally high degree of freedom and unconventional solutions to feed and control the wire electrode. This study designs and reports experimental findings of the first robotic WEDM apparatus based on a high-speed winding system with 600 m of wire length, capable of controlling the wire speed from 1 to 10 m/s and wire tension from 0.1 to 10 N. The system adopts flexible outer cases to travel and reciprocate the wire into a 7-axis robotic system composed of a 6-axis robot and an external rotating axis. The proposed design is a highly dynamic process whose wire tension and speed are achieved by a hybrid controller to cope with the non-linear relation of speed and tension provided by the magnetic clutch. It combines a regression open-loop control for optimality and wire breakage avoidance with a closed-loop control to guarantee admissibility while coping with wire friction disturbances. The findings review a novel wire winding system capable of controlling usual wire disturbance and stepped surface of reciprocating high-speed WEDM as well as additional friction and elastic behaviour of the flexible case, delivering wire tension of ± 12% along with stable EDM process and uniform surface roughness between wire reciprocation areas with a Ra of 2.94 μm. Potential adoption of the method can finally make 6-axis robots a feasible and advantageous technique compared to computer numeric control (CNC) while shaping monolithic and complex workpieces of conductive and hard-to-cut materials.
The isogeometric collocated contact surface approach
Authors: Fahrendorf Frederik , De Lorenzis Laura 
Published: July 2022

AbstractWe propose a frictionless contact formulation for isogeometric analysis, which combines a collocated formulation for the contact surfaces with a standard Galerkin treatment of the bulk. We denote it as isogeometric Collocated Contact Surface (CCS) formulation. The approach is based on a simple pointwise enforcement of the contact constraints, performed in this study with the penalty method. Unlike pointwise (node-to-surface or point-to-surface) contact algorithms in the Galerkin framework, the CCS formulation passes the contact patch test to machine precision by naturally exploiting the favorable properties of isogeometric collocation. Compared with approaches where the discretization of both bulk and contact surfaces is based on collocation, the CCS approach does not need enhancements to remove oscillations for highly non-uniform meshes. With respect to integral contact approaches, the CCS algorithm is less computationally expensive, due to the reduced amount of contact evaluation points. In addition, the CCS approach is easy to code and can be added to a pre-existing isogeometric analysis code with minimal effort. Numerical examples in both small and large deformations are investigated to compare the CCS approach with some available contact formulations and to demonstrate its accuracy.
Black hole algorithm with convolutional neural networks for the creation of brain-computer interface based in visual perception and visual imagery
Authors: Llorella Fabio R. , Azorín José M. , Patow Gustavo 
Published: July 2022

AbstractNon-invasive brain-computer interfaces can be implemented through different paradigms, the most used one being motor imagery and evoked potentials, although recently there has been an interest in paradigms based on perception and visual imagery. Following this approach, this work demonstrates the classification of visual imagery, visual perception and also the possibility of knowledge transfer between these two domains from EEG signals using convolutional neural networks. Also, we propose an adequate framework for such classification, which uses convolutional neural networks and the black hole heuristic algorithm for the search for optimal neural network structures.
Postoperative results and complications of fecal diversion for anorectal Crohn’s disease
Authors: Kuroki Hirosuke , Sugita Akira , Koganei Kazutaka , Tatsumi Kenji , Nakao Eiichi , Obara Nao 
Published: July 2022

AbstractPurposeFecal diversion is a less-invasive technique that can alleviate symptoms in patients with refractory anorectal Crohn’s disease. However, complications, including recurrence of residual anorectal Crohn’s disease, may develop. We aimed to evaluate the postoperative results and complications associated with fecal diversion in patients with refractory anorectal Crohn’s disease.MethodsWe enrolled 1218 Crohn’s disease patients who underwent laparotomy at our institute. We retrospectively analyzed the clinical features of 174 patients who underwent fecal diversion for refractory anorectal Crohn’s disease, complications of the diverted colorectum, and the incidence and risk factors for proctectomy after fecal diversion.ResultsAfter fecal diversion, 74% of patients showed improved symptoms. However, bowel continuity restoration was successful in four patients (2.2%), and anorectal Crohn’s disease recurred in all patients. Seventeen patients developed cancer with a poor prognosis. The rate of conversion to proctectomy after fecal diversion was 41.3%, and the risk factors included rectal involvement (p = 0.02), loop-type stoma (p < 0.01), and the absence of treatment with biologics after fecal diversion (p = 0.03).ConclusionFecal diversion for refractory anorectal Crohn’s disease can improve clinical symptoms. Patients with rectal involvement or loop-type stoma have a greater risk of requiring proctectomy following fecal diversion. The administration of biologic may decrease the rate of proctectomy.
Mineral Composition and Grain Size Effects on the Fracture and Acoustic Emission (AE) Characteristics of Rocks Under Compressive and Tensile Stress
Authors: Du Kun , Sun Yu , Zhou Jian , Khandelwal Manoj , Gong Fengqiang 
Published: July 2022

AbstractThe influence of rock mineral composition and mineral grain size on basic rock strength performance and AE characteristics have been studied, 13 different rocks microstructures are analyzed in an optical microscope thin section using petrographic image analysis, making it possible to determine the mineral composition and mineral texture characteristics of rocks. Then, the basic strength parameters of rock and AE signals generated during fracture propagation were obtained by UCT (uniaxial compression test) and BIT (Brazilian intension test). Finally, the relationship between basic strength parameters and AE characteristics of rock with mineral composition and grain size was analyzed. The results showed that different mineral constituents have significant effects on rock strength. The positive influence of plagioclase content on igneous strength was obtained. Sedimentary rocks strength increases initially and then decreases with the increase of plagioclase content. Besides, with the increase in quartz and K-feldspar content, the strength of the rock was weakened obviously. It is also found that the greater the dimensional deviation of mineral grain, the greater the strength of the rock. The strength of igneous rocks was inversely proportional to the mineral grain size, but there is no correlation between the sedimentary rocks strength and the mineral grain size. Furthermore, the tension–shear crack propagation of rock can effectively distinguish by judging that the data set of the AF–RA density graph was nearby the AF axis or RA axis and the peak frequency data sets of below 100 kHz or more than. Alterations in the rock nature are the main key reasons for the differences between AE hit rate, AE count rate, AE energy, and cumulative energy. The plagioclase content and grain size play a decisive role in AE signal characteristics and failure mode.
Training in virtual reality enables learning of a complex sports movement
Authors: Pastel Stefan , Petri K. , Chen C. H. , Wiegand Cáceres Ana Milena , Stirnatis M. , Nübel C. , Schlotter L. , Witte K. 
Published: July 2022

AbstractDespite the increased use in sports, it is still unclear to what extent VR training tools can be applied for motor learning of complex movements. Previous VR studies primarily relate to realize performances rather than learning motor skills. Therefore, the current study compared VR with video training realizing the acquisition of karate technique, the Soto Uke moving forward in Zenkutsu Dachi, without being accompanied by a trainer or partner. Further analyses showed whether a less lavished forearm compared to a whole-body visualization in VR is necessary to acquire movements’ basics sufficiently. Four groups were tested: 2 groups conducted VR training (VR-WB: whole-body visualization, and VR-FA having only visualized the forearms), the third group passed through a video-based learning method (VB), and the control group (C) had no intervention. In consultation with karate experts, a scoring system was developed to determine the movements’ quality divided, into upper- and lower body performance and the fist pose. The three-way ANOVA with repeated measurements, including the between-subject factor group [VR-WB, VR-FA, VB, C] and the within-subject factors time [pre, post, retention] and body regions [upper body, lower body, fist pose], shows that all groups improved significantly (except for C) with the similar course after four training sessions in all body regions. Accordingly, VR training seems to be as effective as video training, and the transfer from VR-adapted skills into the natural environment was equally sufficient, although presenting different body visualization types. Further suggestions are made related to the features of future VR training simulations.
High rate of missed Barrett’s esophagus when screening with forceps biopsies
Authors: Singer Mendel E. , Odze Robert D. 
Published: July 2022

Abstract
Background
Screening for Barrett’s esophagus (BE) with endoscopy plus forceps biopsy (FB) has poor compliance with the recommended Seattle protocol and fails to sample large areas of mucosa. This statistical modeling study estimates, for the first time, the actual frequency of missed BE cases by FB.

Methods
Published, calibrated models in the literature were combined to calculate the age-specific prevalence of BE in white males with gastroesophageal reflux disease (GERD). We started with estimates of the prevalence of BE and GERD, and applied the relative risk for BE in patients with GERD based on the literature. This created estimates of the true prevalence of BE in white males with GERD by decade of life. The proportion of BE missed was calculated as the difference between the prevalence and the proportion with a positive screen.

Results
The prevalence of BE in white males with GERD was 8.9%, 12.1%, 15.3%, 18.7% and 22.0% for the third through eighth decades of life. Even after assuming no false positives, missed cases of BE were about 50% when estimated for patients of ages 50 or 60 years, and over 60% for ages of 30, 40 or 70 years. Sensitivity analysis was done for all variables in the model calculations. For ages 50 and 60 years, this resulted in values from 30.3 to 57.3% and 36.4 to 60.9%.

Conclusion
Screening for BE with endoscopy and FB misses approximately 50% of BE cases. More sensitive methods of BE detection or better adherence to the Seattle protocol are needed.
Addressing Mental Health and Trauma-Related Needs of Sheltered Children and Families with Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT)
Authors: Spiegel Jamie A. , Graziano Paulo A. , Arcia Emily , Cox Shana K. , Ayala Muriel , Carnero Nicole A. , O’Mara Noelle L. ,   Sundari Foundation
Published: July 2022

Abstract
Children and adolescents (“youth”) experiencing homelessness are at a disproportionately high risk of exposure to potentially traumatic events (PTE). However, limited evidence exists as to what interventions are effective when implemented with this high-risk population. The purpose of this study was to (1) document the mental health and trauma-related needs of sheltered youth and their mothers, and (2) examine the feasibility/effectiveness of Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT) administered within the context of a homeless shelter. Three hundred and twenty-one youth (Mage = 10.06 years, SD = 3.24 years, 56.4% male, 70.1% Black/African American, 34.6% Hispanic/Latinx) and their mothers were recruited from a homeless shelter and provided 10 weeks of TF-CBT, with the option for up to eight additional weeks of therapy based on clinical need. Families completed pre- and post-intervention assessments. Results demonstrated clinically elevated pre-intervention PTSD symptoms and rates of exposure to PTE in sheltered youth well above those previously reported in the general population. TF-CBT resulted in substantial reductions in both maternal and self-reported severity of youth PTSD symptomology, which were largely attributable to reductions in re-experiencing and arousal. Effectiveness of TF-CBT varied by age and the number of exposures to PTE. Overall, these findings illustrate the importance of assessing and addressing the mental health and trauma-related needs of sheltered youth and the feasibility and efficacy of embedding an evidence-based trauma-focused treatment protocol within a shelter environment. Additional implications of these findings are discussed.
A comparative analysis of conventional and speckle-tracking strain echocardiographic findings in diabetic and non-diabetic kidney disease patients with normal ejection fraction
Authors: Paramasivam Ganesh , Rao Indu Ramachandra , Samanth Jyothi , Nayak Krishnananda , Nayak Rakshitha , Martis Simran Agnes , Jerome Rinkle , Nagaraju Shankar Prasad , Prabhu Ravindra Attur , Devasia Tom 
Published: July 2022

AbstractThis study aimed to compare the differences in echocardiographic and strain parameters in patients with diabetic kidney disease (DKD) and non-diabetic kidney disease (NDKD) in a cohort with pre-dialysis chronic kidney disease (CKD) and normal ejection fraction (EF). In this single-center prospective study, patients with CKD stages 3–5 and EF > 55% were included. We compared cardiac structure and function using conventional and speckle-tracking strain echocardiography among DKD and NDKD groups. Cardiovascular outcomes were assessed at the end of the study. Of the included 117 patients, 56 (47.9%) had DKD, and 61 (52.1%) had NDKD. Patients with DKD had higher ratios of early mitral inflow velocity and mitral annular early diastolic velocity (E/e’) (11.9 ± 4.4 vs. 9.8 ± 3.5; p = 0.004), lower septal e’ velocity (7.1 ± 2.5 vs. 8.2 ± 2.8; p = 0.031), lower lateral e’ velocity (9.2 ± 2.9 vs. 10.4 ± 3.8; p = 0.045) and longer deceleration times (209.2 ± 41.5 vs. 189.1 ± 48.0; p = 0.017), compared to those with NDKD. Left ventricular mass index (LVMI), global longitudinal strain (GLS), early diastolic strain rate (SRE), and E/SRE were similar. At a median follow-up of 239 days, 3-P MACE (11.5% vs. 4.9%; p = 0.047) and 4-P MACE (28.6% vs. 11.5%; p = 0.020) were observed to be higher in the DKD group. Diastolic dysfunction was more common in patients with DKD, compared to those with NDKD, although both groups had similar LVMI and GLS. Those with DKD also had poorer cardiovascular outcomes. This highlights the importance of the assessment of diastolic function in CKD, particularly in those with diabetic CKD.
Electrochemotherapy of skin metastases from malignant melanoma: a PRISMA-compliant systematic review
Authors: Ferioli Martina , Lancellotta Valentina , Perrone Anna Myriam , Arcelli Alessandra , Galuppi Andrea , Strigari Lidia , Buwenge Milly , De Terlizzi Francesca , Cammelli Silvia , Iezzi Roberto , De Iaco Pierandrea , Tagliaferri Luca , Morganti Alessio G. 
Published: July 2022

AbstractThe main treatment of MM metastases are systemic therapies, surgery, limb perfusion, and intralesional talimogene laherparepvec. Electrochemotherapy (ECT) is potentially useful also due to the high response rates recorded in cancers of any histology. No randomized studies comparing ECT with other local therapies have been published on this topic. We analyzed the available evidence on efficacy and toxicity of ECT in this setting. PubMed, Scopus, and Cochrane databases were screened for paper about ECT on MM skin metastases. Data about tumor response, mainly in terms of overall response rate (ORR), toxicity (both for ECT alone and in combination with systemic treatments), local control (LC), and overall survival (OS) were collected. The methodological quality was assessed using a 20-item validated quality appraisal tool for case series. Overall, 18 studies were included in our analysis. In studies reporting “per patient” tumor response the pooled complete response (CR) was 35.7% (95%CI 26.0–46.0%), and the pooled ORR was 80.6% (95%CI 68.7–90.1%). Regarding “per lesion” response, the pooled CR was 53.5% (95%CI 42.1–64.7%) and the pooled ORR was 77.0% (95%CI 56.0–92.6%). One-year LC rate was 80%, and 1-year OS was 67–86.2%. Pain (24.2–92.0%) and erythema (16.6–42.0%) were the most frequent toxicities. Two studies reported 29.2% and 41.6% incidence of necrosis. ECT is effective in terms of tumor response and tolerated in patients with skin metastases from MM, albeit with a wide variability of reported results. Therefore, prospective trials in this setting are warranted.