bluuebunny/crossref_metadata_2025_split huggingface dataset:
MXene‐Regulated Perovskite Vertical Growth for High‐Performance Solar Cells
Authors: Wu Chao , Fang Wenzhong , Cheng Qunfeng , Wan Jing , Wen Rui , Wang Yang , Song Yanlin , Li Mingzhu 
Published: September 2022

AbstractDefects at the interfaces of perovskite (PVK) thin films are the main factors responsible for instability and low photoelectric conversion efficiency (PCE) of PVK solar cells (PSCs). Here, a SnO2‐MXene composite electron transport layer (ETL) is used in PSCs to improve interfacial contact and passivate defects at the SnO2/perovskite interface. The introduced MXene regulates SnO2dispersion and induces a vertical growth of PVK. The lattice matching of MXene and perovskite suppresses the concentration of interfacial stress, thereby obtaining a perovskite film with low defects. Compared with SnO2‐based device, the PCE of SnO2‐MXene‐based device is improved by 15 % and its short‐circuit current is up to 25.07 mA cm−2. Furthermore, unencapsulated device maintained about 90 % of its initial efficiency even after 500 h of storage at 30–40 % relative humidity in ambient air. The composite ETL strategy provides a route to engineer interfacial passivation between metal halide perovskites and ETLs.
Foraminifera as a model of the extensive variability in genome dynamics among eukaryotes
Authors: Goetz Eleanor J. , Greco Mattia , Rappaport Hannah B. , Weiner Agnes K. M. , Walker Laura M. , Bowser Samuel , Goldstein Susan , Katz Laura A. 
Published: September 2022

AbstractKnowledge of eukaryotic life cycles and associated genome dynamics stems largely from research on animals, plants, and a small number of “model” (i.e., easily cultivable) lineages. This skewed sampling results in an underappreciation of the variability among the many microeukaryotic lineages, which represent the bulk of eukaryotic biodiversity. The range of complex nuclear transformations that exists within lineages of microbial eukaryotes challenges the textbook understanding of genome and nuclear cycles. Here, we look in‐depth at Foraminifera, an ancient (∼600 million‐year‐old) lineage widely studied as proxies in paleoceanography and environmental biomonitoring. We demonstrate that Foraminifera challenge the “rules” of life cycles developed largely from studies of plants and animals. To this end, we synthesize data on foraminiferal life cycles, focusing on extensive endoreplication within individuals (i.e., single cells), the unusual nuclear process calledZerfall, and the separation of germline and somatic function into distinct nuclei (i.e., heterokaryosis). These processes highlight complexities within lineages and expand our understanding of the dynamics of eukaryotic genomes.
Achieving sustainability: Determinants of conscious green purchasing behavior during the COVID‐19 pandemic
Authors: Yang Xianchuan , Jiang Jiayun , Chen Shih‐Chih 
Published: September 2022

AbstractThe COVID‐19 pandemic has spread worldwide, resulting in crises in public health and sustainable development. Aimed at understanding the determinants of conscious green purchasing behavior (GPB), this paper developed a comprehensive framework linking the moderating effect of negative environmental affective reactions (NEAR) to COVID‐19 based on the S–O–R paradigm. Using randomly selected urban residents from China's Yangtze River Delta and Bohai Rim regions, the empirical study was conducted using 559 valid responses. The results show that media and peers are the major social forces activating altruistic and egoistic motivations, while family influence was not significant. Dual motivations significantly mediated the relationships of unconditional and conditional GPB with media exposure and peer influence. Contrary to expectations, NEAR negatively moderated the formation process of conscious GPB. The findings indicate that the influence of peers on conscious GPB through dual motivations is stronger compared to media. Negative affective reactions to COVID‐19 were also found to inhibit the impact of peer influence on altruistic and egoistic motivations, as well as the path of altruistic motivation on unconditional GPB. The results of this study have important theoretical and practical implications for enterprise marketing and environmental campaigns, and narrowing the green attitude‐behavior gap.
A nomogram involving immune‐inflammation index for predicting distant metastasis‐free survival of major salivary gland carcinoma following postoperative radiotherapy
Authors: Yan Wenbin , Ou Xiaomin , Shen Chunying , Hu Chaosu 
Published: September 2022

AbstractBackgroundPostoperative radiotherapy (PORT) is beneficial in the improvement of local‐regional control and overall survival (OS) for major salivary gland carcinomas (SGCs), and distant metastasis remained the main failure pattern. This study was designed to develop a nomogram model involving immune‐inflammation index to predict distant metastasis‐free survival (DMFS) of major SGCs.Patients and MethodsA total of 418 patients with major SGCs following PORT were randomly divided into a training (n = 334) and validation set (n = 84). The pre‐radiotherapy neutrophil‐to‐lymphocyte ratio (NLR), and platelet‐to‐lymphocyte ratio (PLR) were calculated and transformed as continuous variables for every patient. Associations between DMFS and variables were performed by univariate and multivariable analysis using Log‐rank and Cox regression methods. A nomogram was constructed based on the prognostic factors identified by the Cox hazards model. The decision curve analysis (DCA) was conducted with the training and validation set.ResultsThe estimated 3‐, 5‐, and 10‐year DMFS were 79.4%, 71.8%, and 59.1%, respectively. The multivariate analysis revealed that age (p = 0.033), advanced T stage (p = 0.003), positive N stage (p < 0.001), high‐risk pathology (p = 0.011), and high PLR (p = 0.001) were significantly associated with worse DMFS. The nomogram showed good calibration and discrimination in the training (AUC = 80.9) and validation set (AUC = 87.9). Furthermore, the DCA demonstrated favorable applicability, and a significant difference (p < 0.001) was observed for the DMFS between the subgroups based on the nomogram points.ConclusionThe nomogram incorporating clinicopathological features and PLR presented accurate individual prediction for DMFS of the patients with major SGCs following PORT. Further external validation of the model is warranted for clinical utility.
A New Approach to Research Data Management with a Focus on Traceability: Adacta
Authors: Gossler Hendrik , Riedel Johannes , Daymo Eric , Chacko Rinu , Angeli Sofia , Deutschmann Olaf 
Published: September 2022

AbstractTraceability between samples, devices and data is of great importance to the catalysis community. Adacta is a new research data management (RDM) system designed to create a traceable digital twin of a testing environment, not only storing data, but also creating a readily retrievable time‐accurate record of the critical components used to measure catalyst performance. Future developments include extending Adacta to interact with electronic laboratory notebooks and to spawn simulations directly using data and measurements stored in the database.
Ein Rumtopf chemisch betrachtet
Authors: Kostka Kathrin , Kruse Benedikt , Fischer Carola , Epple Matthias 
Published: September 2022

ZusammenfassungEin Rumtopf konserviert die eingelegten Früchte durch Alkohol und Zucker. Dabei mischen sich die Inhaltsstoffe des umgebenden Rum‐Zucker‐Gemischs (insbesondere Alkohol und Zucker) rasch mit den Inhaltsstoffen der eingelegten Früchte (insbesondere Wasser und rote Pflanzenfarbstoffe). Um eine unbeabsichtigte Gärung zu verhindern, sollte möglichst hochprozentiger Rum verwendet werden.
Cardiac rehabilitation: Effective yet underutilized in patients with cardiovascular disease
Authors: Bracewell Natalie J. , Plasschaert Jeffrey , Conti Charles Richard , Keeley Ellen C. , Conti Jamie B. 
Published: September 2022

AbstractCardiac rehabilitation is a comprehensive program that treats patients with multiple cardiac conditions including post‐myocardial infarction, stable angina, post‐coronary artery bypass surgery, chronic heart failure, and peripheral vascular disease with structured exercise, and nutrition and risk factor counseling. It is an effective tool that has been shown to improve not only quality of life but also reduce adverse cardiac events, including death. While the value of cardiac rehabilitation is supported by a large body of evidence and its recommendation by the American Heart Association/American College of Cardiology it is significantly underutilized due to both patient and systemic factors. Continued efforts should be made to remove the obstacles to make cardiac rehabilitation available to all those who qualify.
Mitochondria‐Targeting Boron Dipyrromethene Based Photosensitizers for Enhanced Photodynamic Therapy: Synthesis, Optical Properties, and in vitro Biological Activity
Authors: Hu Ping , Weng Xiao‐Lu , Zhu Chun‐Hui , Yang De‐Chao , Liu Jian‐Yong , Chen Zhuo , Huang Mingdong 
Published: September 2022

AbstractIncreasing Investigations show that photosensitizers (PSs) which target mitochondria are useful for enhancing photodynamic therapy (PDT) efficacy. Herein, we carefully designed and synthesized four triphenylphosphonium (TPP)‐modified boron dipyrromethene (BDP)‐based PSs through Cu(I)‐assisted “3+2” cycloaddition reaction. All of them exhibit intense red light absorption with maxima between 659 and 663 nm, considerable fluorescence emission with quantum yields of 0.16–0.23, high singlet oxygen generation efficiency ranging from 0.22 to 0.34, excellent mitochondria‐targeting ability, and good biocompatibility. Upon illumination, they induce significant cancer cell death through a mitochondria‐related apoptosis pathway. The IC50 values of these BDP dyes against MCF‐7 cells were determined to be as low as 0.046–0.113 μM under rather low dosage of light irradiation (1.5 J ⋅ cm−2).
Comparison of the fracture resistance of the teeth prepared with ProTaper Universal, ProTaper Next, and ProTaper Gold rotary files
Authors: Salem Milani Amin , Ganjpour Shabnam , Dehghani Fatemeh , Rahimi Saeed , Sabanik Pouya 
Published: September 2022

AbstractObjectivesRoot canal preparation can lead to cracks on the roots by creating stresses on the root canal walls, which decreases the fracture resistance of the tooth. The present study compared the fracture resistance of the teeth prepared by the ProTaper Universal (PTU), ProTaper Next (PTN), and ProTaper Gold (PTG) rotary file systems.Materials and MethodsFifty‐six single‐canal premolar teeth were sectioned 14 mm from the root apex. The roots were standardized based on the buccolingual and mesiodistal diameter and randomly assigned to three experimental (n = 14) and one control group (n = 14). The teeth in three experimental groups were instrumented with PTU, PTN, and PTG rotary files. The roots in the control group were not instrumented. A vertical force was applied to each root in a universal testing machine until the root fractured. The data were statistically analyzed by one‐way analysis of variance.ResultsThere was no significant difference in the fracture resistance of the teeth between the control, PTU, PTN, and PTG groups (p = .115).ConclusionsRoot canal preparation with ProTaper files manufactured with conventional NiTi (PTU) and heat‐treated alloys (PTN and PTG) did not affect the fracture resistance of teeth.
Preliminary effectiveness of a cognitive‐behavioral, family‐centered partial hospitalization program for children and adolescents with avoidant/restrictive food intake disorder
Authors: Billman Marley G. , Forrest Lauren N. , Johnson Mariah , Quaill Marlana A. , King Steven , Mausteller Kyle , Lane‐Loney Susan E. , Essayli Jamal H. 
Published: September 2022

AbstractObjectiveThis study explored the preliminary effectiveness of a partial hospitalization program (PHP) for children/adolescents with avoidant/restrictive food intake disorder (ARFID). We evaluated how ARFID symptoms changed from admission to discharge, and collected follow‐up data on symptoms and outpatient care following PHP discharge.MethodTwenty‐two children/adolescents with ARFID (77.3% White, 63.6% female) completed measures assessing ARFID symptomatology at admission and discharge from a PHP for eating disorders. Six months and twelve months following their discharge, participants were contacted to complete study measures again and take part in an interview assessing follow‐up care.ResultsPaired samples t tests indicated that participants demonstrated increases in weight and decreases in ARFID symptomatology from admission to discharge with medium to large effects. All participants reported receiving some form of outpatient treatment following discharge, with the type of outpatient services varying across participants. Data from the 86% of participants who completed the six‐month follow‐up and 50% who completed the twelve‐month follow‐up suggest that participants generally maintained treatment gains following PHP discharge.DiscussionParticipants experienced symptom improvements from admission to discharge and appeared to maintain these gains after discharge. These results provide preliminary evidence that PHPs are an effective treatment option for children and adolescents with ARFID.Public Significance StatementThis study provides preliminary evidence that intensive, evidence‐based PHPs are effective in treating ARFID. Our findings suggest that children and adolescents with ARFID who receive flexible, cognitive‐behavioral, family‐centered treatment in a PHP for EDs experience improvements in weight and ARFID symptomatology from admission to discharge. Despite receiving variable and nonstandardized outpatient treatment, individuals with ARFID appear to maintain treatment gains 6 and 12 months after discharge in a PHP.
Evaluation and tradeoff‐synergy analysis of ecosystem services in Luanhe River Basin
Authors: Feng Xiangrong , Zhang Ting , Feng Ping , Li Jianzhu 
Published: September 2022

AbstractThe evaluation of watershed ecosystem services and the research on their trade‐offs and synergies are of great significance for the rational formulation of environmental policies. Taking Luanhe River Basin as an example, based on InVEST and CASA models, the temporal and spatial distribution characteristics of the water yield, soil conservation and carbon sequestration in 1990, 2000, 2010 and 2015 were analysed, where correlation analysis was utilized to explore the tradeoff‐ synergy relationship among various ecosystem services. And by mapping the hotspots of the ecosystem services, the spatial differences of ecological environment conditions were revealed in Luanhe River Basin. The results show that (1) from 1990 to 2015, water yield and soil conservation declined in a fluctuating manner, and carbon sequestration first decreased, then increased. The three services all showed a pattern of increasing gradually from northwest to southeast in space. (2) The relationship between the ecosystem services showed that water yield and carbon sequestration were mainly in a trade‐off relationship, while water yield and soil conservation, soil conservation and carbon sequestration were mainly in synergistic relationships. In different regions, trade‐offs and synergies changed to different degrees, showing obvious spatial heterogeneity. (3) The southeastern part of the study area was the main hotspot for ecosystem service supply. From 1990 to 2015, the areas of non‐hotspots showed a decreasing trend. Ecosystem service hotspots have expanded, and overall ecological environment has improved significantly, but ecological environment has been degraded in some areas.
Comparative study of continuous hourly energy consumption forecasting strategies with small data sets to support demand management decisions in buildings
Authors: Mariano‐Hernández D. , Hernández‐Callejo L. , Solís M. , Zorita‐Lamadrid A. , Duque‐Pérez O. , Gonzalez‐Morales L. , Alonso‐Gómez V. , Jaramillo‐Duque A. , Santos García F. 
Published: September 2022

AbstractBuildings are one of the largest consumers of electrical energy, making it important to develop different strategies to help to reduce electricity consumption. Building energy consumption forecasting strategies are widely used to support demand management decisions, but these strategies require large data sets to achieve an accurate electric consumption forecast, so they are not commonly used for buildings with a short history of record keeping. Based on this, the objective of this study is to determine, through continuous hourly electricity consumption forecasting strategies, the amount of data needed to achieve an accurate forecast. The proposed forecasting strategies were evaluated with Random Forest, eXtreme Gradient Boost, Convolutional Neural Network, and Temporal Convolutional Network algorithms using 4 years of electricity consumption data from two buildings located on the campus of the University of Valladolid. For performance evaluation, two scenarios were proposed for each of the proposed forecasting strategies. The results showed that for forecasting horizons of 1 week, it was possible to obtain a mean absolute percentage error (MAPE) below 7% for Building 1 and a MAPE below 10% for Building 2 with 6 months of data, while for a forecast horizon of 1 month, it was possible to obtain a MAPE below 10% for Building 1 and below 11% for Building 2 with 10 months of data. However, if the distribution of the data captured in the buildings does not undergo sudden changes, the decision tree algorithms obtain better results. However, if there are sudden changes, deep learning algorithms are a better choice.
Forecasting inflation time series using score‐driven dynamic models and combination methods: The case of Brazil
Authors: de Castro Carlos Henrique Dias Cordeiro , Aiube Fernando Antonio Lucena 
Published: September 2022

AbstractThis paper evaluates the inflation forecasting models of a small open economy. We compare forecasts of Brazilian inflation (consumer price index—IPCA) based on the generalized autoregressive score (GAS) approach with the forecasts reported in the Focus Bulletin (the Brazilian Central Bank's weekly consensus survey report), as well as with other benchmark models. We selected a restricted number of the variables used most in the literature to compose the forecasting models. Furthermore, based on a confidence set, we applied a wide range of combination methods to the forecast components aiming at improving the forecasting power. Point and density forecast tests were performed to verify the performance of the models. The results showed that the GAS models had good predictive performance for the IPCA, and it was possible to improve their accuracy by combining them with other models.
Loss of oligodendrocyte ErbB receptor signaling leads to hypomyelination, reduced density of parvalbumin‐expressing interneurons, and inhibitory function in the auditory cortex
Authors: Borges Beatriz C. , Meng Xiangying , Long Patrick , Kanold Patrick O. , Corfas Gabriel 
Published: September 2022

AbstractFor a long time, myelin was thought to be restricted to excitatory neurons, and studies on dysmyelination focused primarily on excitatory cells. Recent evidence showed that axons of inhibitory neurons in the neocortex are also myelinated, but the role of myelin on inhibitory circuits remains unknown. Here we studied the impact of mild hypomyelination on both excitatory and inhibitory connectivity in the primary auditory cortex (A1) with well‐characterized mouse models of hypomyelination due to loss of oligodendrocyte ErbB receptor signaling. Using laser‐scanning photostimulation, we found that mice with mild hypomyelination have reduced functional inhibitory connections to A1 L2/3 neurons without changes in excitatory connections, resulting in altered excitatory/inhibitory balance. These effects are not associated with altered expression of GABAergic and glutamatergic synaptic components, but with reduced density of parvalbumin‐positive (PV+) neurons, axons, and synaptic terminals, which reflect reduced PV expression by interneurons rather than PV+ neuronal loss. While immunostaining shows that hypomyelination occurs in both PV+ and PV− axons, there is a strong correlation between MBP and PV expression, suggesting that myelination influences PV expression. Together, the results indicate that mild hypomyelination impacts A1 neuronal networks, reducing inhibitory activity, and shifting networks towards excitation.
Monitoring postoperative ambulation and sleep after head and neck surgery: Feasibility and utility study using wearable devices
Authors: Pandrangi Vivek C. , Jorizzo Matthew , Shah Suparna , Bruening Jennifer , Wax Mark K. , Clayburgh Daniel , Andersen Peter , Li Ryan J. 
Published: September 2022

AbstractBackgroundTo evaluate use of wearable activity devices to monitor trends in ambulation and sleep after head and neck surgery.MethodsPatients utilized Fitbit devices after surgery. Daily activity and sleep scores, step counts, and total sleep time (TST) were obtained.ResultsThere were 30 patients within the final cohort. Trends in step counts after specific procedures were identified, and higher subjective activity level correlated with step counts (r = 0.25, 95% CI = 0.07–0.41). Among patients with complete step data (n = 24), POD1 steps ≥200 were associated with reduced length of stay (4.5 ± 1.7 days vs. 7.2 ± 4.0 days, 95% CI = 0.33–5.0). Mean TST was 5.4 ± 2.5 h, TST correlated with subjective sleep scores (r = 0.25, 95% CI = 0.03–0.044), and clinical events associated with sleep–wake transitions on Fitbit devices were identified.ConclusionsWearable activity devices appear feasible for monitoring trends in postoperative ambulation and sleep. Use of these devices may facilitate postoperative recovery.
Characterization of Morreton virus as an oncolytic virotherapy platform for liver cancers
Authors: Nagalo Bolni Marius , Zhou Yumei , Loeuillard Emilien J. , Dumbauld Chelsae , Barro Oumar , Elliott Natalie M. , Baker Alexander T. , Arora Mansi , Bogenberger James M. , Meurice Nathalie , Petit Joachim , Uson Pedro Luiz Serrano , Aslam Faaiq , Raupach Elizabeth , Gabere Musa , Basnakian Alexei , Simoes Camila C. , Cannon Martin J. , Post Steven R. , Buetow Kenneth , Chamcheu Jean Christopher , Barrett Michael T. , Duda Dan G. , Jacobs Bertram , Vile Richard , Barry Michael A. , Roberts Lewis R. , Ilyas Sumera , Borad Mitesh J. 
Published: September 2022

Background:
Morreton virus (MORV) is an oncolytic Vesiculovirus, genetically distinct from vesicular stomatitis virus (VSV).

Aim:
To report that MORV induced potent cytopathic effects (CPEs) in cholangiocarcinoma (CCA) and hepatocellular carcinoma (HCC) in vitro models.

Approach and Results:
In preliminary safety analyses, high intranasal doses (up to 1010 50% tissue culture infectious dose [TCID50]) of MORV were not associated with significant adverse effects in immune competent, non–tumor‐bearing mice. MORV was shown to be efficacious in a Hep3B hepatocellular cancer xenograft model but not in a CCA xenograft HuCCT1 model. In an immune competent, syngeneic murine CCA model, single intratumoral treatments with MORV (1 × 107 TCID50) triggered a robust antitumor immune response leading to substantial tumor regression and disease control at a dose 10‐fold lower than VSV (1 × 108 TCID50). MORV led to increased CD8+ cytotoxic T cells without compensatory increases in tumor‐associated macrophages and granulocytic or monocytic myeloid‐derived suppressor cells.

Conclusions:
Our findings indicate that wild‐type MORV is safe and can induce potent tumor regression via immune‐mediated and immune‐independent mechanisms in HCC and CCA animal models without dose limiting adverse events. These data warrant further development and clinical translation of MORV as an oncolytic virotherapy platform.