bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ongoing evolution of Beet necrotic yellow vein virus towards Rz1‐resistance breaking in Europe
Authors: Liebe Sebastian , Varrelmann Mark 
Published: May 2022

AbstractOver the last three decades, the control of Beet necrotic yellow vein virus (BNYVV) in sugar beet has relied on the cultivation of varieties harbouring the Rz1 resistance gene. The strong selection pressure on BNYVV has favoured the development of resistance‐breaking strains that display mutations at amino acid positions 67–70 (tetrad) in the pathogenicity factor P25 and strains possessing an additional RNA component (RNA5). To evaluate the durability of Rz1 resistance, it is essential to monitor the ongoing virulence development in BNYVV populations. Therefore, we characterized BNYVV populations from different fields in Europe suspected to possess resistance‐breaking properties. The ability to overcome Rz1 resistance could be confirmed for several populations in greenhouse bait plant tests using susceptible and resistant genotypes. These populations were able to accumulate similar virus concentrations in both genotypes. Most of the populations harboured multiple P25 tetrad variants, but there was no obvious effect of the sugar beet genotype on their composition. The strong selection pressure on P25 was reflected by the overall high number of P25 haplotypes with several amino acids under positive selection. Two different RNA5 species closely related to either the French or the Asian RNA5 type were additionally identified in some populations. Finally, high‐throughput sequencing revealed the formation of genetic reassortments between different virus types, but the overall sequence diversity within BNYVV populations was relatively low and not affected by the genotype. Our results highlight the ongoing adaption of BNYVV towards Rz1 resistance, stressing the importance of alternative resistance sources.
Stay or exit: How do international nongovernmental organizations respond to institutional pressures under authoritarianism?
Authors: Li Hui , Farid May 
Published: May 2022

AbstractInternational nongovernmental organizations (INGOs) are increasingly important players in global politics and development. However, they are undergoing significant adaptations as governments worldwide have instituted restrictions to regulate their activities. What explains the various ways in which they respond to these institutional pressures? In our study of INGO responses to a new restrictive law in China, we identify four strategic responses with varying levels of compliance: legal registration, provisional strategy, localization, and exit. The institutional pressures—strategic responses link is influenced by INGOs' adaptive capacity, which is in turn shaped by an organization's issue sensitivity, value‐add, government ties, and reputational authority. The integrated framework we develop for INGO strategic responses can shed light on state‐INGO relations in other countries, many of which are subject to increasingly stringent regulations and a closing political environment.
AcneGrader: An ensemble pruning of the deep learning base models to grade acne
Authors: Liu Shuai , Fan Yusi , Duan Meiyu , Wang Yueying , Su Guoxiong , Ren Yanjiao , Huang Lan , Zhou Fengfeng 
Published: May 2022

AbstractBackgroundAcne is one of the most common skin lesions in adolescents. Some severe or inflammatory acne leads to scars, which may have major impacts on patients’ quality of life or even job prospects. Grading acne plays an important role in diagnosis, and the diagnosis is made by counting the number of acne. It is a labor‐intensive job and it is easy for dermatologists to make mistakes, so it is very important to develop automatic diagnosis methods. Ensemble learning may improve the prediction results of the base models, but its time complexity is relatively high. The ensemble pruning strategy may solve this computational challenge by removing the redundant base models.Materials and methodsThis study proposed a novel ensemble pruning framework of deep learning models to accurately detect and grade acne using images. First, we train multi‐base models and prune the redundancy models according to the performance and diversity of the models. Then, we construct the new features of the training data by the base models we select in the previous step. Next, we remove the redundancy models further by a feature selection algorithm. Finally, we integrate all the base models by classifiers. The ensemble pruning algorithm was proposed to prune the deep learning base models.ResultsThe experimental data showed that the ensemble pruned framework achieved a prediction accuracy of 85.82% on the acne dataset, better than the existing studies. To verify our method's effectiveness, we test our method in a skin cancer dataset and greatly outperform the state‐of‐the‐art methods.ConclusionThe method we proposed is used to grade acne. Our method's performance outperforms state‐of‐the‐art methods on two datasets, and it can also remove redundancy models to reduce computational complexity.
Stem cell‐mediated angiogenesis in skin tissue engineering and wound healing
Authors: Azari Zoleikha , Nazarnezhad Simin , Webster Thomas J. , Hoseini Seyed Javad , Brouki Milan Peiman , Baino Francesco , Kargozar Saeid 
Published: May 2022

AbstractThe timely management of skin wounds has been an unmet clinical need for centuries. While there have been several attempts to accelerate wound healing and reduce the cost of hospitalisation and the healthcare burden, there remains a lack of efficient and effective wound healing approaches. In this regard, stem cell‐based therapies have garnered an outstanding position for the treatment of both acute and chronic skin wounds. Stem cells of different origins (e.g., embryo‐derived stem cells) have been utilised for managing cutaneous lesions; specifically, mesenchymal stem cells (MSCs) isolated from foetal (umbilical cord) and adult (bone marrow) tissues paved the way to more satisfactory outcomes. Since angiogenesis plays a critical role in all four stages of normal wound healing, recent therapeutic approaches have focused on utilising stem cells for inducing neovascularisation. In fact, stem cells can promote angiogenesis via either differentiation into endothelial lineages or secreting pro‐angiogenic exosomes. Furthermore, particular conditions (e.g., hypoxic environments) can be applied in order to boost the pro‐angiogenic capability of stem cells before transplantation. For tissue engineering and regenerative medicine applications, stem cells can be combined with specific types of pro‐angiogenic biocompatible materials (e.g., bioactive glasses) to enhance the neovascularisation process and subsequently accelerate wound healing. As such, this review article summarises such efforts emphasising the bright future that is conceivable when using pro‐angiogenic stem cells for treating acute and chronic skin wounds.
Neurosyphilis mimicking giant cell arteritis both clinically and microscopically
Authors: van Ruitenbeek Niels , van Kasteren Marjo , Bouma-de Krijger Annet 
Published: May 2022

Temporal arteritis is usually caused by giant cell arteritis (GCA). However, inflammation of the temporal artery can also occur secondary to autoimmune diseases or infections.We present a remarkable case of a man in his 70s with biopsy proven temporal arteritis, who was later diagnosed with meningovascular neurosyphilis. The presentation of an acute onset monocular vision loss with inflammation of the temporal artery on biopsy appeared a GCA, misleading the physicians, as it turned out to be a manifestation of neurosyphilis.
The process of developing health workforce strategic plans in Africa: a document analysis
Authors: Nyoni Jennifer , Christmals Christmal Dela , Asamani James Avoka , Illou Mourtala Mahaman Abdou , Okoroafor Sunny , Nabyonga-Orem Juliet , Ahmat Adam 
Published: May 2022

BackgroundMany countries are faced with a multitude of health workforce-related challenges partly attributed to defective health workforce planning. Earlier efforts to guide the process and harmonise approaches to national health workforce policies and planning in the Africa Region included, among others, the development of the WHO Africa Regional Office (WHO/AFRO) Policies and Plans for Human Resources for Health Guidelines for Countries in the WHO African Region in 2006. Although this guideline has led to uniformity and rigour in developing human resources for health (HRH) policies and strategies in Africa, it has become imperative to synthesise the emerging evidence and best practices in the development of health workforce strategies.MethodsA document analysis was conducted using the READ (Readying materials;Extracting data;Analysing data andDistilling) approach.ResultsFourteen HRH policy/strategic plans were included in the study. The scope of the HRH strategic plans was described in three dimensions: the term of the strategy, sectors covered by the strategy and the health workforce considered in the projections. We found that HRH strategic plan development can be conceptualised as a cyclical, sequential multimethod project, with one phase feeding the subsequent phase with data or instructions. The process is very complex, with different interest groups and sectors that need to be satisfied. The HRH strategic plan development process comprises five main phases linked with external forces and national politics.ConclusionThere is a need for accurate and comprehensive HRH data collection, astute HRH leadership, and broad base and multisectoral stakeholder consultation with technical support and guidance from experts and major external partners for effective HRH strategic plan development.
Predictors of treatment response in a lupus nephritis population: lessons from the Aspreva Lupus Management Study (ALMS) trial
Authors: McDonald Stephen , Yiu Sean , Su Li , Gordon Caroline , Truman Matt , Lisk Laura , Solomons Neil , Bruce Ian N 
Published: May 2022

ObjectivesTo identify predictors of overall lupus and lupus nephritis (LN) responses in patients with LN.MethodsData from the Aspreva Lupus Management Study (ALMS) trial cohort was used to identify baseline predictors of response at 6 months. Endpoints were major clinical response (MCR), improvement, complete renal response (CRR) and partial renal response (PRR). Univariate and multivariate logistic regressions with least absolute shrinkage and selection operator (LASSO) and cross-validation in randomly split samples were utilised. Predictors were ranked by the percentage of times selected by LASSO and prediction performance was assessed by the area under the receiver operating characteristics (AUROC) curve.ResultsWe studied 370 patients in the ALMS induction trial. Improvement at 6 months was associated with older age (OR=1.03 (95% CI: 1.01 to 1.05) per year), normal haemoglobin (1.85 (1.16 to 2.95) vs low haemoglobin), active lupus (British Isles Lupus Assessment Group A or B) in haematological and mucocutaneous domains (0.61 (0.39 to 0.97) and 0.50 (0.31 to 0.81)), baseline damage (SDI>1 vs =0) (0.38 (0.16 to 0.91)) and 24-hour urine protein (0.63 (0.50 to 0.80)). LN duration 2–4 years (0.43 (0.19 to 0.97) vs <1 year) and 24-hour urine protein (0.63 (0.45 to 0.89)) were negative predictors of CRR. LN duration 2–4 years (0.45 (0.24 to 0.83) vs <1 year) negatively predicted PRR. The AUROCs of models for improvement, CRR and PRR were 0.56, 0.55 and 0.51 respectively.ConclusionsBaseline variables predicted 6-month outcomes in patients with SLE. While the modest performance of models emphasises the need for new biomarkers to advance this field, the factors identified can help identify those patients who may require novel treatment strategies.
The mechanical behaviour of Bolders Bank till
Authors: Ushev Emil , Jardine Richard 
Published: May 2022

Advanced sampling and testing techniques are applied to assess the mechanical behaviour of a stiff, silt-and-clay dominate, stony, low plasticity UK till whose genesis and post-depositional history imparted complex profiles of yielding pressures and shear strengths that differ considerably from those of K0 consolidated waterborne sediments. It is shown that the till reaches the limits of its elastic behaviour and undergoes Y1 yielding at very small strains, after which stiffness is nonlinear. Tests reach stable critical state failures at strains exceeding 25%. The Y1 yield surface is kinematic and, once engaged, travels with the effective stress path, as does a second Y2 surface. Stiffnesses vary with mean effective stress raised to fractional exponent ≈0.5. The till displays far more marked sample size dependency and anisotropy in stiffness than in shear strength. It also shows significantly strain-rate dependent behaviour and displays an isotach response. The main features of the till’s shear strength and dilatancy behaviour can be synthesised within a critical state based interpretive framework that brings field and in situ testing outcomes together with laboratory experiments conducted over a wide range of stress levels and overconsolidation ratios, considering both natural and reconstituted specimens.
Fluid sources and mineralizing processes in greenstone belts: a stable isotope (O, H) comparison between the weakly mineralized Moly-Desgagné–Guercheville system and Val-d’Or orogenic gold deposits, Canada
Authors: Kieffer Marie A. , Scheffer Christophe , Quesnel Benoît , Bedeaux Pierre , Beaudoin Georges , Mathieu Lucie , Gaboury Damien 
Published: May 2022

In orogenic gold systems, the source of the fluids and the processes leading to mobilization, transport, and deposition of gold remain debated. Most studies focus on endowed rather than on gold-poor orogenic systems to unravel the “key” parameters of gold mineralizing processes. Here, we present stable isotope (O, H) data from the Moly-Desgagné–Guercheville fault system (gold-free to low gold endowment) in the Chibougamau area, Abitibi greenstone belt, Canada. The gold-free Moly-Desgagné showing and nearby poorly endowed Hazeur showing and Monster Lake deposit share similar features typical of orogenic systems. The stable isotope compositions of tourmaline and quartz from the Moly-Desgagné–Guercheville fault system also display similar characteristics, such as (1) temperature of vein formation of 345 ± 86 °C (1σ); (2) fluid mixing between an upper crustal reservoir (low T – high δD – low δ18O) and a metamorphic water reservoir (high T – low δD – high δ18O); and (3) positive δDfluid values consistent with multiple boiling-condensation cycles related to fault-valve processes. These characteristics are similar to those from the gold-endowed Val-d’Or vein field. The difference in gold endowment between the Moly-Desgagné–Guercheville and Val-d’Or vein fields may be related to the nature of the fault system (i.e., terrane-bounding or “intragreenstone belt”) and the volume and (or) composition (i.e., gold, its ligands, CO2) of the fluid source rocks.
Influence of maternity penning on the success and timing of parturition by mountain caribou (Rangifer tarandus caribou)
Authors: Mueller M. , Johnson C.J. , McNay R.S. 
Published: May 2022

Invasive conservation actions that require the capture and handling of individual animals are common, but the implications for both survival and reproduction are often not studied. Across North America, most populations of woodland caribou ( Rangifer tarandus caribou (Gmelin, 1788)) are Threatened or Endangered. Maternity penning, where pregnant females are held in an enclosure until the calf is less vulnerable to predation, is one conservation action that is designed to increase population growth. Few studies have reported the influence of maternity penning on the occurrence or timing of parturition and the implications for reproduction. We quantified parturition success and dates of penned and free-ranging caribou within the Klinse-Za population of caribou found across east-central British Columbia, Canada. Parturition dates were identified using daily observations for penned caribou ( n = 41) and estimated dates for free-ranging caribou ( n = 27) generated using statistical modelling of GPS collar data. We related parturition outcomes to a range of ecological and environmental variables. We found that the occurrence and date of parturition did not differ between penned and free-ranging caribou. For all monitored animals there was an earlier calving date during years of higher snowfall and warmer winter weather. Our results suggested that maternity penning, a potentially invasive conservation action, did not increase or decrease the probability or date of parturition for this study population.
Enhancing quantum teleportation fidelity under decoherence via weak measurement with flips
Authors: Harraz Sajede , Cong Shuang , Nieto Juan J. 
Published: May 2022

AbstractNoiseless quantum channels are critical to share a pure maximally entangled state for performing an ideal teleportation protocol. However, in reality the shared entanglement severely degraded due to decoherence. In this paper, we propose a quantum teleportation channel protection scheme to enhance the teleportation fidelity in presence of decoherence. Before the entangled pair enters the decoherence channel, the weak measurement and flip operations are applied to transfer the qubit to a more robust state to the effects of the noise. After the decoherence channel the reversed flip operations and weak measurement reversal are applied to recover the initial state. We illustrate our protected teleportation scheme and compare it with a protocol based on weak measurement reversal. The numerical results show that the average teleportation fidelity of our proposed scheme can be significantly improved. Although the proposed entanglement protection scheme is probabilistic, after a successful entanglement transmission, we use the standard teleportation protocol which has probability one.
Relativistic charged stellar model of the Pant interior solution via gravitational decoupling and Karmarkar conditions
Authors: Pant Neeraj , Gedela Satyanarayana , Ray Saibal , Sagar Kumar Gaurav 
Published: May 2022

This paper explores a new embedding anisotropic charged version of a solution to Einstein–Maxwell field equations in four-dimensional spacetime through the Karmarkar conditions and the gravitational decoupling via minimal geometric decoupling (MGD) technique by choosing Pant’s interior solution [Astrophys. Space Sci. 331, 633 (2011)] as a seed solution to coupled system. Later, we integrate the coupled system within the MGD and explore a family of solutions to represent the realistic structure of nonrotating compact objects. Through the matching of the interior solutions so obtained to the exterior Reissner–Nordström metric, we tune the arbitrary constants for feasible models. After that, we subject our model to a rigorous test for a chosen parameter space to verify the physical viability of the solution for the neutron stars in EXO 1785-248 for a range of values of the decoupling constant [Formula: see text]. Further, we prove that the constant [Formula: see text] is inherently connected to critical physical properties such as the gravitational and surface redshifts, compactification factor, mass/radius relation, etc., of the same compact star candidate EXO 1785-248. The solutions thus obtained exhibit physically viable features which are thoroughly demonstrated through graphical plots.
Thermophysical behavior in Y2O3 under high intensity fast neutron irradiation
Authors: Dashdemirov A. O. , Huseynov J. I. , Rzayev R. F. , Alıyev Y. I. 
Published: May 2022

In this work, differential scanning calorimetric (DSC) analyses were performed in an Ar inert medium in the temperature range of 100–750 K for the Y2O3 compound with the purity rate of 99.99%, the density in powder form is 0.069 g/cm3, the specific surface area is 100–150 m2/g, the particle size is in the range of 8–10 nm irradiated with fast neutrons with different intensities ([Formula: see text] MeV). Using mathematical approximation methods, the equations of dependence of the heat flux function on temperature and heat capacity after irradiation at different intensities for the Y2O3 compound over a wide temperature range were determined. It was found that in the temperature range of [Formula: see text] K, the value of the heat flux increases by 16.6%, up to 86 mW for the case of maximum radiation. At all radiation intensities, anomalies recorded with very small changes were observed in the spectra of the heat flux function related to the internal structural transitions.
Host status of Bambara groundnut accessions to Meloidogyne incognita using conventional screenhouse and novel seedling pouch methods
Authors: Ayeni Beulah P. , Claudius-Cole Abiodun O. , Abberton Michael , Coyne Danny 
Published: May 2022

Summary
Bambara groundnut (Vigna subterranea) is an underexploited legume indigenous to sub-Saharan Africa with high protein content. Production constraints of Bambara groundnut include the root-knot nematodes (Meloidogyne spp.), which causes substantial losses that present an additional burden that growers need to manage. In this study we: i) assessed genetic resistance against Meloidogyne incognita in Bambara groundnut; and ii) evaluated an improved, more efficient screening method for Bambara. Fifty accessions were evaluated in two screenhouse trials. Following this, the use of seedling pouches was assessed for a high throughput screening method, using two accessions identified from each of three host status categories (resistant, tolerant and susceptible). Variability in host response was observed between the trials but five accessions demonstrated good resistance to M. incognita. A general reduction in plant growth parameters was observed on inoculated plants, especially for chlorophyll content at 11 weeks after planting. The pouch screening system confirmed the screenhouse pot results but appears to be more sensitive. From a range of inocula no differences in gall index were observed over the 28 days of assessment in pouches but the number of egg masses proved a useful parameter and differed between inoculum levels, with 500 juveniles/eggs determined as the optimum inoculum level. The use of seedling pouches reduced time, space and cost to screen Bambara groundnuts for resistance against M. incognita. Consequently, it is recommended as an efficient, high throughput, rapid screening protocol for Bambara groundnut compared to conventional pot screening methods.
Jurisdiction and its attribution in the works of Diodorus Tuldenus (1594-1645)
Authors: Sluijs Geert 
Published: May 2022

Summary
Diodorus Tuldenus (1594-1645) as a professor of the Digest at the University of Leuven is one of the most representative figures for legal academia in the Southern Low Countries in this period. After a brief biography, this article deals with a classic subject in the field of public law as discussed by Tuldenus in his works: jurisdiction and its attribution. In chapter one, the genealogy of the terms iurisdictio and imperium is traced until Tuldenus’ treatment of the subject, situating his position vis-à-vis the state of the art. In the second chapter the same is done for the conditions under which this jurisdiction can be attributed. In the conclusion, a tentative link is drawn between Tuldenus’ positions and their broader political ramifications.