bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial Nutritional Status of Patients with Mitochondrial Disease: A Retrospective Study
Authors: Shin Geum-ji , Na Ji-Hoon , Lee Hyunjoo , Lee Young-Mock 
Published: March 2022

Abstract
BACKGROUND:Mitochondrial disease (MD) is a rare condition characterized by the dysfunction of mitochondrial DNA. Patients with MD are vulnerable to malnutrition due to adenosine triphosphate dysfunction, which disrupts gastrointestinal system function. Nutritional screening and assessment of these patients are important because malnutrition increases mortality and disease-related complications. This study aimed to investigate the nutritional status at the time of diagnosis and the need for targeted nutritional therapy in patients with MD according to subgroups.METHODS:We enrolled 91 patients diagnosed with clinical MD who were considered at high risk of malnutrition based on the Gangnam Severance Hospital’s criteria. We divided them into three subgroups (Leigh syndrome; mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes [MELAS]; non-specific MD) and compared the nutritional status of the subgroups based on nutrition-related indices.RESULTS:Most of the patients with MD were classified as having a high risk of malnutrition. Lactic acidosis and vitamin D insufficiency and deficiency were the most common in patients with MELAS and non-specific MD. Among the subgroups, patients with obesity were more likely to have Leigh syndrome than the other two subtypes, whereas those who were underweight were more likely to have MELAS or non-specific MD than Leigh syndrome. Gastroesophageal reflux disease was the most common in the non-specific MD group.CONCLUSIONS: The nutritional status of patients with MD was poor at the time of diagnosis. As the nutritional status of patients belonging to different subgroups varied, each patient required individualized nutritional therapy.
Evidence Of The Drying Technique’s Impact On The Biomass Quality Of Tetraselmis Subcordiformis (Chlorophyceae)
Authors: Jabri Hareb Al , Cherif Maroua , Siddiqui Simil Amir , Bounnit Touria , Saadaoui Imen 
Published: March 2022

Abstract
Rapid drying, cost-effective and safe, will increase the viability of using microalgae for several bio-industrial applications. In this study, five different drying techniques of microalgal biomass were investigated. These include freeze-drying, oven drying, air drying, sun drying, and microwave drying. Morphology, metabolite content, FAME profiling, chlorophyll content, total organic carbon, and total nitrogen were analyzed. Results showed that the freeze-drying technique preserves the highest amounts of chlorophyll, proteins, and lipids. Oven drying underperformed as it retained the lowest amount of chlorophyll, protein, and lipid content. More importantly, FAME profiling results showed that air drying was the best technique in maintaining the highest amount of Polyunsaturated fatty acids and more specifically docosahexaenoic acid. Furthermore, this process requires the least capital and energy needs. The findings from this study confirmed that the drying technique affects the microalga biomass quality.
Perioperative Oral Nutritional Support For Patients Diagnosed With Primary Colon Adenocarcinoma Undergoing Radical Surgical Procedures -Peri-Nutri Trial: Study Protocol For A Randomized Controlled Trial.
Authors: Aro Raila , Ohtonen Pasi , Rautio Tero , Saarnio Juha , Mäkäräinen Elisa , Häivälä Reetta , Mäkinen Markus J. , Tuomisto Anne , Schwab Ursula , Meriläinen Sanna 
Published: March 2022

Abstract
Background: Colon cancer is one of the most common cancers in Finland and worldwide. Cancer-related malnutrition is a well-known risk factor for increased morbidity and mortality after surgery, and it is associated with complications and longer hospitalizations. There are no established recommendations on how to improve the nutritional status of colon cancer patients´ during the perioperative phase. Administration of simple oral nutritional supplements has been suggested to reduce complication rates, but evidence to support this practice is scarce.Methods and analysis: The Peri-Nutri trial is a prospective, multicenter, randomized, controlled trial. Its primary endpoint is to evaluate whether perioperative oral nutritional support (ONS) decreases the number of complications during the 30-day follow-up after surgery. Secondary endpoints are to study the effect of ONS on quality of life after surgery, length of stay in institutional care, 90-day mortality rate, five-year disease-free survival and overall survival. The patients with a Nutritional risk screening 2002 (NRS-2002) questionnaire result between 2 and 5 (≥3 are classified at risk of malnutrition) will be randomized (1:1 ratio) into either the intervention or control group. The intervention group will receive preoperative ONS two weeks before the operation, and nutritional support will continue 10 days after the operation. The control group will not receive ONS. A total of 318 patients will be randomized into two groups. Ethics/dissemination: The study has been conducted according to the SPIRIT statement. All participants will be signed a written consent form, and the study has been approved by the The Ethics Committee at the Oulu University Hospital. The findings will be presented at international or national conferences and will be published in clinical journals. Trial registration number: ClinicalTrials.gov, NCT03863236, Registered 25 February 2019, https://clinicaltrials.gov/ct2/show/NCT03863236
Clinical Characteristics of Anisomyopia in Identical Twins and Management: A Case Report
Authors: Sivaraman Viswanathan , Balaji Janarthanam Jothi 
Published: March 2022

Abstract
Anisomyopia (anisometropic myopia) is defined as an inter-ocular difference greater than one dioptre between eyes among myopic individuals. The co-occurrence of anisomyopia in siblings is extremely rare. A pair of 9-year-old identical twin sisters reported to a tertiary eye care centre for myopia management. In this case report, we evaluated the clinical findings and the structural features of anisomyopia including retinal imaging. The siblings were corrected for anisomyopia with full and optimal correction and closely monitored for progression pattern. Since the annual progression was higher than − 0.75 D, a low dose atropine 0.01% was prescribed. This report also warrants a need for prescribing guidelines for anisomyopic subjects in different age groups.
Internet of Things based Framework for Smart Healthcare Using Hybrid Machine Learning
Authors: Okemiri Henry , Uzoma Alo , Christopher Nnamene 
Published: March 2022

Abstract
The world has been facing the challenge of increased cardiovascular death rate for decades now. The utilization of machine learning techniques coupled with the power of Internet of Things can be an effective solution to this real world problem. This research presents Internet of Things based framework for smart healthcare using hybrid machine learning for monitoring heart disease, a system specifically designed for wearable devices that facilitates heart diseases monitoring. The system uses wearable sensors to collect observable vital signs which is contextualized with data from clinical database for a high efficiency in analysis and prediction. Internet of Things and Machine Learning have gained wide applicability in the healthcare sector. The problem of inaccurate Electrocardiogram interpretation and high dependency on individual interpretation, coupled with delayed analysis and diagnosis of patients and lack of accurate prognosis are what this research solves. Machine learning was used accurate analysis and predictions of diseases while the internet of things components was communicating the server for smartness. The framework consists of some components like data collection using wearable sensors, data analysis center, which uses hybridized machine learning algorithms, to quickly identify potential cardiovascular cases from real-time symptom data. This facilitates real-time communication between doctor and patient through wearable technologies. With this, real-time analysis and monitoring of cardiovascular disease would be possible. This system instead of transferring the raw data collected from patients directly to the health care professionals, sends those data to a python platform for analysis on the local device by feeding the hybrid of collected data to Random Forest, Naïve Bayes and Support Vector Machine (SVM) algorithms to analyze and monitor features extracted from clinical databases and wearable sensors and then classify a patient as “Negative” or “Positive” for heart disease. In this research, Object Oriented Methodology and Analysis was used with arduino and python programming languages. The results of our experiment showed that the system was successful in both analysis and classification of a patient’s heart disease with an accuracy of 87.6% for the hybrid machine learning. Random Forest model has a precision and recall that exceeded 100%, 75% precision and 65% recall for Naïve Bayes model and 77% precision and 56% recall for support vector machine. We used UCI clinical dataset of 1025 samples of patients with 25% for test data and 75% for the data training.
Gender, Numbers and Beyond: The Case of Criminology Program in DOrSU, City Of Mati, Philippines
Authors: Villegas Jhonnel P. , Biol Ruel C. , Dacullo Jason E. , Simbahon Juby S. 
Published: March 2022

Abstract
Access to and success in higher education is shaped by various factors, including, but are not limited to, gender, gendered identities, and gender-related subjectivities. While there has been rich literature in gender-higher education nexus, the utilization of gender analysis in specific gender-stereotyped degree programs such as Criminology, although widely offered in the entire country, remains understudied. Recognizing the impressive progress of enterprising and mainstreaming GAD norms in the Philippines compared to its peers in Asia, there remains a need to understand how gender sets in motion beyond rhetoric and how it entangles everyday practices. This study attempts to interrogate the Criminology program’s temporal development and social determinants from the lenses of gender through trend analysis and in-depth interview methods.We found that Criminology in DOrSU is significantly male-dominated since the program commenced operations in 2009. Although unsurprising, it is worth noting that females record a higher survival rate than males. The latent gender issues and coping strategies contributing to the program’s notable trendwere also uncovered, providing a more comprehensive understanding of females and other non-masculine genders’ narrowed access to the program. To tighten the existing gender gap in Criminology, we recommend a policy reform that encourages gender-inclusive opportunities.
Hydrocele of canal of Nuck in adult females – A series of two cases
Authors: Malik D S , Dhakad B S , Choudhary Mahipal Singh , Aurora Nisha 
Published: March 2022

Abstract
Hydrocele of canal of Nuck in adult females is exceptionally rare.The canal of Nuck is the portion of processus vaginalis in the inguinal canal in women. This is homologous to the processus vaginalis of male anatomy .Although canal of Nuck normally disappears without a trace in the first year of life but if it remains patent, then it can lead to development of indirect inguinal hernia or hydrocele of canal of Nuck. Ultrasonography is the preferred investigation. Magnetic resonance imaging (MRI) done to confirm the diagnosis preoperatively .The treatment remains the excision of hydrocele of canal of nuck. We are presenting two cases of hydrocele of canal of Nuck in adult female, one Bilateral and another unilateral which were treated by laparoscopic excision of hydrocele with mesh repair .
Vagus Activation by Cold Face Test Reduces Acute Psychosocial Stress Responses
Authors: Richer Robert , Zenkner Janis , Küderle Arne , Rohleder Nicolas , Eskofier Bjoern M. 
Published: March 2022

Abstract
Chronic stress is linked to dysregulations of the two major stress pathways – the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis, which could for example result from maladaptive responses to repeated acute stress. Improving recovery from acute stress could therefore help to prevent this dysregulation. One possibility of physiologically interfering with an acute stress reaction might be provided by applying a cold stimulus to the face (Cold Face Test, CFT) which activates the parasympathetic nervous system, leading to immediate heart rate decreases. Therefore, we investigated the use of the CFT protocol as an intervention to reduce acute stress responses. Twenty-eight healthy participants were exposed to acute psychosocial stress via the Montreal Imaging Stress Task (MIST) in a randomized between-subjects design while heart rate (HR), heart rate variability (HRV), and salivary cortisol were assessed. While both groups were equally stressed during the procedure, participants with CFT intervention showed better recovery, indicated by significant (p < 0.05) differences in HR(V). We additionally found a significantly (p < 0.05) lower cortisol response to the MIST and less overall cortisol secretion in the CFT condition. Both findings indicate that the CFT can successfully inhibit both the SNS and the HPA axis. To the best of our knowledge, our experiment is the first to successfully use the CFT as a simple and easy-to-apply method to modify biological responses to acute stress.
A novel technique for endoscope progression in gastroscopy resection: “6”- turn of gastroscopy along the greater curvature wall for dissection of stromal tumor in the muscularis propria of the gastric fundus
Authors: Liu Lu , Guo Hai-Mei , Sun Ying , Cai Shuang , Miao Feng , Zheng Yan , Yu Yang , Zhao Zhi-Feng 
Published: March 2022

Abstract
Objective: The fundus of the stomach is a challenging region for endoscopic resection of gastrointestinal stromal tumors (GISTs), especially in the anterior wall of the fornix at the side of the greater curvature. The aim of this study was to introduce using the “6”-turn of gastroscopy along the greater curvature wall (6TGS) technique in operation on the gastric fundus and provide evidence of its advantages.Methods: The clinical data of patients with stromal tumor in muscularis propria at the gastric fundus (STMF) at the Fourth Hospital of China Medical University between July 2016 and Dec 2020 were reviewed. The novel 6TGS technique was used in the procedure. The beneficial effects, suitability, applicable lesion site, influencing factors, and success rates of 6TGS were analyzed.Results: Ten cases in total were reviewed, and the 6TGS technique was successfully performed in 7 cases (70%). In all 7 patients, the gastroscope’s tip could access the location just below the gastric cardia, and all angles/sites of the fundus of the stomach could be operated on. The lesion was easily accessed, and the gastroscope was stable with good left-right movement ability and moderate forward and backward movement ability. Conclusion: 6TGS can improve the safety of gastroscopy resection of STMF and facilitate the excision of tumors in challenging sites in the gastric fundus. Patients need to be under general anesthesia with endotracheal intubation in the supine position to perform the 6TGS technique after distending the stomach with less air.
Molecular Signature Of Subtypes Of Renal Cell Carcinomas And Immunotherapy Strategy
Authors: Guo JiaNing , Yu Xi , He Bin , Liu ShengLai , Jiang Ning 
Published: March 2022

Abstract
Purpose: Classified immunogenomic profiling based on therapeutic responses in RCC subtypes.Methods: Tumors from RCC patients from The Cancer Genome Atlas (TCGA) cohort were analyzed, and genomic profiling was performed. We classified RCC on the basis of the immunogenomic profiling of 29 immune signatures.Results: We investigated the transcriptional changes of three RCC subtypes by RNA-seq. Gene ontology (GO) identify specific gene signatures differed significantly between KIRC, KIRP and KICH related to the distinct pathways. Site of origin within the nephron was one major determinant in the molecular and immune classification, reflecting differences between three subtypes. The Immunity High KIRC and KIRP subtype was enriched not only in immune signatures, but also including PD-L1 expression signaling, NF-kappa B signaling pathway, JAK-STAT signaling pathway and Cell cycle signaling pathway. KICH was a distinct disease that shared little genomic characteristics with KIRC and KIRP.Conclusions: The identification of RCC subtypes based on immune signatures has potential clinical implications for RCC treatment. It is imaginable that patients with higher immunity subtype of KIRC and KIRP would be more likely to respond to anti-PD-1/ PD-L1 therapy than patients with KICH subtype. CCL21 and CCL25 might be a potential target for KICH therapy.
An experience of multi-dimensional symptom assessment for children treated in a tertiary paediatric oncology unit: a prospective survey-based study
Authors: Katz Naomi T , Sacks Bronwyn H , Vemuri Sidharth , Williams Molly , Bhatia Kanika , Hynson Jenny 
Published: March 2022

Abstract
Background: Children undergoing cancer-directed treatment experience distressing symptoms. Multi-dimensional patient-reported symptom assessment scales have been validated in children with cancer, but are not routinely used in clinical practice. Aim: To describe the symptom prevalence and burden for children receiving treatment in a paediatric oncology unit, as described by both children where possible, and their parents. Methods: Prospective survey-based study during which the Memorial Symptom Assessment Scale was administered to children and parents. Participants were offered the opportunity to complete the survey on multiple occasions. Demographic and clinical data were obtained from electronic medical records. Results: Forty-one children were recruited, aged 8 months to 18 years and 54% were female. In total, 54 parent surveys and 29 child surveys were completed. The vast majority of surveys (81%) were completed in the inpatient setting, and more than half within 10 days of chemotherapy. Haematological malignancies predominated. There was a median of 4.8 months between diagnosis and recruitment. Eleven children died after the study closed; no patients died during the study period. Symptom prevalence did not always correlate with distress. Conclusions: Exploration of the impact of a symptom, and not just its presence, is vital for patient-centred care and can be achieved using multi-dimensional symptom scales. Both the child and caregiver’s voices should be obtained where possible. Further studies are needed to explore how these scales can be used to identify distress and guide supportive care delivery.
TreeSp2Vec: a method for developing tree species embeddings using deep neural networks
Authors: González-Rodríguez Miguel A. , Diéguez-Aranda Ulises 
Published: March 2022

Abstract
In recent years, Representation Learning (RL), a subdiscipline of artificial intelligence, has proved a useful resource in many research fields for effectively mapping abstract categories into numeric scales. In this study, we explored a novel application of RL to forest ecology, labeled TreeSp2Vec, for developing tree species numeric representations using deep neural networks and data from a National Forest Inventory. Our approach consisted of a supervised species classification of individual trees using as input a set phytocentric and geocentric variables derived from forest inventory data and environmental cartography. Among the tested neural network architectures, a multi-layer perceptron with two hidden layers of 1024 units and an embedding layer of 16 units provided the best apparent and test performances (Matthew’s Correlation Coefficient = 0.89). The developed latent representations (W), or embeddings, were evaluated intrinsically by estimating their correlations with supplementary species descriptors that were not included in the training dataset. The evaluation analysis revealed some significant associations that proved the generality of the embedding model. Some latent dimensions (e.g., W6 and W16) were useful for differentiating species general features, such as conifers vs broad-leaved species, while other dimensions (e.g., W2 and W5) were related to forest ecosystem characteristics such as competition intensity (relative spacing index) and biodiversity (Simpson index). We concluded that the developed embeddings provided accurate and generalizable numeric representations of the considered tree species, which can be used as a ground for further cutting-edge forest modelling approaches and open a new range of artificial intelligence applications in ecology.
Study of efficiency of berry extracts in the technology of semi-smoked sausages
Authors: Pasichnyi Vasyl , Bozhko Nataliia , Tischenko Vasyl , Marynin Andriy , Shubina Yevgenia , Svyatnenko Roman , Haschuk Oleksandra , Moroz Olena 
Published: March 2022

The work is devoted to the study of the effectiveness of the use of berry extracts (Aronia melanocarpa Elliot and Ribes nigrum L.) in the technology of semi-smoked sausages. The aim of the study was to study the effectiveness of the use of berry extracts (Aronia melanocarpa Elliot and Ribes nigrum L.) in the technology of semi-smoked sausages. The raw minced semi-smoked sausages were supplemented with the above-mentioned extracts in concentrations of 0.2–0.5 % of the weight of raw materials in order to slow down the oxidative processes in the lipid fraction of the product. Studies of the antioxidant efficiency of berry extracts and the effect on microbiological stability were performed during the shelf life of the finished product.
It has been found, that the introduction of the chokeberry extract in a concentration of 0.2 to 0.5 % of the weight of minced meat significantly inhibits the hydrolytic oxidation of lipids in the finished product, resulting in reduced intensity of lipid peroxidation. It has been confirmed, that the stabilization of lipid peroxidation in semi-smoked sausages leads to inhibition of the formation of primary oxidation products. At the end of the shelf life of the PV (peroxide value) of the test samples was at least 0.017 mg/KOH (potassium hydroxide), which was 63.04 % less than in the control.
The study of the content of secondary oxidation products allowed to estimate the depth of oxidation processes, occurring in the samples of semi-smoked sausages when stored for 25 days at a temperature of 0–6 °C. It has been proved, that the amount of secondary oxidation products, reacting with thiobarbituric acid, was the lowest at the end of the shelf life of the finished product with a concentration of the chokeberry extract of 0.5 %. TBV (thiobarbituric value) of this sample was 0.197±0.001 mg MA/kg, which was 3.74 times lower than in the control.
The introduction of extracts can reduce microbiological contamination and achieve a bacteriostatic effect. The lowest total contamination was recorded in a sample with a concentration of the chokeberry extract of 0.5 %. The tendency to decrease MAFAnM (number of mesophilic aerobic and facultative anaerobic microorganisms) was noted in all experimental samples. And in direct proportion to the concentration of extracts. Comparative evaluation of the effectiveness of the preparations showed that the extract of chokeberry in a concentration of 0.5 % more effectively inhibits oxidative processes than the extract of black currant