bluuebunny/crossref_metadata_2025_split huggingface dataset:
Matching-adjusted indirect comparison of isatuximab plus carfilzomib and dexamethasone with daratumumab plus lenalidomide and dexamethasone in relapsed multiple myeloma
Authors: Richter Joshua , Lin Peggy , Garcia-Horton Viviana , Guyot Patricia , Singh Erin , Zhou Zheng-Yi , Sievert Mark , Taiji Riley 
Published: July 2022

Abstract
Lenalidomide-based regimens are commonly used for early relapse in patients with relapsed and/or refractory multiple myeloma (RRMM) receiving at least one prior line of therapy. In the absence of head-to-head comparison, matching-adjusted indirect comparison (MAIC) was conducted to demonstrate efficacy and safety of isatuximab+carfilzomib+dexamethasone (Isa-Kd) vs. daratumumab+lenalidomide+dexamethasone (Dara-Rd) in RRMM. Patient-level data from IKEMA trial (Isa-Kd, n=179) were matched to aggregate data from POLLUX (Dara-Rd, n=286). Hazard ratios (HR) and 95% confidence intervals (CI) for progression-free survival (PFS) and overall survival (OS) were generated by weighted Cox proportional hazard models. Odds ratios (OR), 95% CI, and p-value were calculated for ≥very good partial response (≥VGPR) and treatment-emergent adverse events (TEAEs). After matching, no significant differences were observed between Isa-Kd and Dara-Rd in baseline characteristics except for patients with >3 prior lines (0.0% vs. 4.9%). Isa-Kd showed significantly better PFS (HR [95% CI]: 0.46 [0.24–0.86]; p=0.0155), statistically non-significant improvement favoring Isa-Kd in OS (0.47 [0.20–1.09]; 0.0798), and ≥VGPR (OR [95% CI]: 1.53 [0.89–2.64]; p=0.1252) than Dara-Rd. Odds of occurrence were significantly lower for some all-grade and grade 3/4 TEAEs with Isa-Kd than Dara-Rd. These results support Isa-Kd as an efficacious treatment for early relapse in non-lenalidomide refractory patients.
Flow dynamics through discontinuous clogs of rigid particles in tapered microchannels
Authors: Majekodunmi Olukayode T. , Hashmi Sara M. 
Published: July 2022

Abstract
Suspended particles flowing through complex porous spaces exhibit clogging mechanisms determined by factors including their size, deformability, and the geometry of the confinement. This study describes the clogging of rigid particles in a microfluidic device made up of parallel microchannels which taper from the inlet to the outlet, where the constriction width is approximately equal to the particle size. This geometry summarizes the dynamics of clogging in flow channels with constrictions that narrow over multiple length scales. Flow tests are conducted at constant driving pressures for different particle volume fractions, and a power-law decay which appears to be peculiar to the tapered geometry of the channels is observed in all cases. In comparison with non-tapered channels, the power-law exponent shows the flowrate decay rate is significantly lower in a tapered channel. Also, micrographs of the clogged channels reveal the clogs do not grow continuously from their initial points of inception. Rather, multiple clogs with increasing number of particles in their cross section are successively formed as the cake grows in each microchannel. Changes in particle volume fraction at a constant driving pressure affect the clogging rate without impacting the underlying clogging dynamics. Unexpectedly, analyses of the particles packing behavior in the microchannels and post-clogging permeability reveal the presence of two distinct regimes of driving pressure, though only a small portion of the total device volume and channels surface area were occupied by clogs, regardless of the particle volume fraction.
Thermodynamic Parameters of Phenylglycine Interaction withUO22+, La3+ and Zr4+
Authors: El-Dossoki Farid I. , Mohamed Abd Allah Abd El-Wahab 
Published: July 2022

Abstract
The interactions between phenylglycine and some transition metal ions (UO22+,La3+ and Zr4+) were studied at three ionic strengths [(µ = 0.05, 0.10 and 0.15) M KNO3] and three temperatures [(25, 35 and 45) ºC] in aqueous media by using Bjerrum’s potentiometric technique. The stoichiometric and thermodynamic stability constants as well as the degree of formation n ̅ for all studied systems were determined and discussed. The standard thermodynamic parameters (Δ pKº and ΔlogKº) and the thermodynamic parameter differences (ΔGº, ΔΔGº, ΔHº, ΔΔHº, ΔSº, and ΔΔSº) were calculated for all possible reactions. Advanced discussions of these functions as well as the factors that may control the complexation processes from the thermodynamic point of view have been reported.
Decarbonization and Energy Policy Instruments in the EU: Does Explicit Carbon Pricing Prevail?
Authors: Stepanov Ilya , Albrecht Johan 
Published: July 2022

Abstract
Carbon pricing is a key element in climate policy, but carbon taxes and emissions trading schemes nowadays only cover around 15% of global emissions. Although historically not imposed for climate-related purposes, economy-wide general energy taxes (e.g. motor fuel taxes) can equally contribute to emission reductions. This paper clarifies the contribution to emission reductions of explicit carbon pricing (carbon taxes and the EU ETS) compared to indirect carbon pricing (general energy taxes) based on the data for 31 European countries in the period 2002-2018. Our two-way panel regression suggests that a 1% increase in explicit and indirect carbon prices leads on average to a 0.6% and 0.9% reduction in emissions respectively. Our results confirm the importance of explicit carbon pricing, but the less discussed general energy taxes have not less impact on emission dynamics.
Peanut shell biochar increases rice yield in highly saline-alkali paddy fields by regulating of leaf ionic concentration and improving leaf photosynthesis rate
Authors: Jin Feng , Piao Junlong , Che Weikang , Li Xuebin , Zhang Chengbo , Wang Qingshu , Hua Shuang 
Published: July 2022

Abstract
Aims
Saline-alkali soil seriously restricts the crop growth and production. Biochar addition could alleviate the adverse impacts of saline-alkali stress in crops. However, little information is available on the ionic accumulation and photosynthesis rate of rice in highly saline-alkali paddy fields. This study aimed to evaluated the influence of the peanut shell biochar on leaf ionic concentration, stress physiology indices, photosynthesis related parameters and rice yield in highly saline-alkali paddy field condition.
Methods
Field experiment was conducted using two nitrogen applied rate treatments (0 and 225 kg N ha− 1) and four biochar applied rate treatments (0%, 1.5%, 3.0% and 4.5% w/w). The field experiment was arranged in a complete randomized design with three replications.
Results
The results show that peanut shell biochar significantly reduced the leaf Na+ concentration, Na+/K+ ratio, abscisic acid and malondialdehyde concentration of rice, while enhanced leaf K+ content, and improved leaf water status and relative electrical leakage in treatments both with or without N fertilization. Furthermore, peanut shell biochar could provide beneficial effects on chlorophyll content, leaf N content, leaf area index, photosynthetic potential, stomatal conductance, and transpiration rates, which is of great benefit to the enhancement of leaf photosynthesis rate and net assimilation rate of rice population. In addition, the biomass, grain yield and harvested index were remarkably increased.
Conclusions
These results indicated that peanut shell biochar could effectively ameliorate saline–alkali stress and increase rice yield by regulating of leaf ionic concentration and improving leaf photosynthesis rate.
Specific lncRNA signatures discriminate childhood acute leukemias: a pilot study
Authors: Buono Lorena , Iside Concetta , De Matteo Antonia , Stellato Pio , Beneduce Giuliana , Penta Roberta , Parasole Rosanna , Salvatore Marco , Smaldone Giovanni , Mirabelli Peppino 
Published: July 2022

Abstract
BackgroundLong non-coding RNAs are RNAs longer than 200 bps that do not encode any proteins and are able to alter gene expression by acting on different steps of regulation, including DNA methylation and chromatin structure. They represent a class of biomarkers of crescent interest in the hematologic and oncologic fields. Recent studies showed that the expression levels of specific lncRNAs correlate with the prognosis of paediatric patients with Acute Lymphoblastic Leukaemia.MethodsWe used NGS approaches to analyse the transcriptome of 9 childhood B-ALL patients and 6 childhood T-ALL patients, in comparison with B and T healthy lymphocytes from cord blood. We validate our findings both ex vivo, in a different cohort of 10 B-ALL and 10 T-ALL patients, and in silico using public datasets.ResultsWe characterised the lncRNA landscape for B-ALL, T-ALL, healthy B, and T cell progenitors. From the characterised signature, we selected candidate lncRNAs able to discriminate not only B-ALL and T-ALL from healthy subjects but also between the two types of leukaemia, and subsequently validated their potential as a diagnostic tool in an additional cohort of paediatric patients. We confirmed our finding with open access transcriptomic data, comparing ALL lncRNAs with AML lncRNA landscape as well. Finally, expression correlation analyses of T-ALL selected lncRNA biomarkers suggested a possible role in lymphocyte activation and the β-catenin signalling pathway for AC247036.1 and involvement in hedgehog signalling for HHIP-AS1.ConclusionsOur work identified a lncRNA signature discriminating paediatric B-ALL and T-ALL from healthy subjects, between them and from AML. This study provides the keystone to future clinical studies determining the theragnostic value of the characterised long non coding transcriptome panorama in a clinical setting for childhood patient management.
Bilateral Breast and Ovarian Metastases of Signet-ring Cell Gastric Cancer: A Case Report and Literature Review
Authors: Li Qiang , Zhang Zhengwei , Feng Ziyu , Wei Wan , Shi Jianhua 
Published: July 2022

Abstract
Background
Breast cancer metastasis accounts for only 0.4–2% of all breast cancer cases. Gastric cancer with breast metastases is extremely rare, while mammary and ovarian metastases from the stomach are even more uncommon. Breast metastases might be mistaken for primary cancer due to their uncommon and generic clinical and radiological symptoms, leading to ineffective and debilitating therapy.
Case Presentation:
We present a 43-year-old woman with bilateral multiple metastases from stomach signet-ring cell carcinoma to the breast and ovary, which is the seventh case to our knowledge.
Conclusion
We highlight the epidemiological, diagnostic, therapeutic, and prognostic aspects of this extremely rare disease through our case, which are critical to understand in order to avoid diagnostic errors and subsequent incorrect care.
Treatment of tibial plateau fractures by modified posterior medial approach
Authors: Sun Weijun , Zheng Yusong 
Published: July 2022

Abstract
PurposeTo report the effect of posterior medial approach preserving pes anserinus in the treatment of tibial plateau fracture.MethodPatients who underwent surgery in a large hospital due to tibial plateau fractures from December 2013 to January 2021 were retrospectively analyzed.These patients underwent a posteromedial approach preserving the pes anserinus and a traditional posteromedial approach.The general information, fracture classification, preoperative and postoperative conditions of the patients were recorded and compared. HSS score and VAS score were used to evaluate knee function and pain respectively.ResultAll patients were followed for more than 1 year.In general, there were no statistically significant differences to the baseline demographic factors between the two groups.The patients in the observation group had longer operation time, more intraoperative bleeding and intraoperative fluoroscopy times, the difference was statistically significant.The observation group had lower VAS scores, either on day 1, day 3 or day 14 after surgery.The observation group had a better HSS score 3 months after operation, and the difference was statistically significant. However, there was no significant difference in HSS score between the two groups one year after operation.Similarly, the patients in the observation group had better knee range of motion 3 months after operation, and the difference was statistically significant. However, there was no significant difference in HSS score between the two groups one year after operation.ConclusionIn conclusion, compared with the traditional posteromedial approach, the modified posteromedial approach with pes anserinu preserved can significantly reduce soft tissue injury in the operative area, relieve early postoperative pain, and improve early knee range of motion.
A qualitative study of the interaction experiences between family caregivers and community nurses for disabled elderly people at home
Authors: Guo Panpan , Wang Shiguang , Niu Meilan , Li Ling , Wu Chuqiao , Zhao Di , Yang Huashan , Ma Rui , Wang Peng 
Published: July 2022

Abstract
Background: Family members are currently the main caregivers of the disabled elderly people at home. With declining health and increasing frailty, caregiving of disabled elderly people becomes a task of family caregivers in conjunction with community nurses. Interaction between family caregivers and community nurses can effectively improve the quality of home care for the disabled elderly people. This study aimed to investigate the interaction experiences between family caregivers and community nurses for disabled elderly people at home.Methods: This research was a qualitative study based on semi-structured interviews. Qualitative data were collected from family caregivers of the disabled elderly and community nurses in Zhengzhou city, Henan Province. Conceptual content analysis and Colaizzi’s method was used to generate qualitative codes and identify themes.Results: A total of 12 interviews were completed, including 7 family caregivers and 5 community nurses. Three themes were identified: 1)Establish a collaborative relationship ; 2)Get professional support; 3) Factors that promote and hinder the interaction.Conclusions: Findings from this study suggested that the interaction between family caregivers and community nurses will be very beneficial, which will reduce the burden of family caregivers and improve the quality of care for disabled elderly people. Providing a new perspective that we can develop and implement intervention to facilitate positive interactions and bring the highest quality of care to older adults with disabilities.
The regulatory effect of miR-221/222 on endothelial differentiation of adipose-derived stem cells
Authors: Gao Wei , Yuan Liming , Zhang Yue , Si Yue , Wang Yushuai 
Published: July 2022

Abstract
Objective
Adipose-derived stem cells (ADSCs) are a kind of adult mesenchymal stem cell, which show a repair effect in ischemic tissues due to its capacity of endothelial differentiation. MicroRNA‑221/222 (miR‑221/222) has been extensively studied in endothelial cells (ECs). However, the mechanism that regulates ADSCs differentiation toward ECs is unknown. In this work, we investigated the effects of miR-221/222-overexpressing/silence in ADSCs on endothelial differentiation by construction of lentiviral vectors.
Methods
The differentiative capacity was assessed by measuring the expression of endothelial markers (CD31, CD34, CD144 and eNOS). Meanwhile, the low-density lipoprotein (LDL) uptake and tube-like formation were performed for evaluation of functional characterization. In order to clarify the function mechanism of this gene, the PI3K/AKT signaling pathway was investigated by western blotting. The revascularization of miR-221/222-transfeted ADSCs were further verified in vivo experiment.
Results
The results confirmed that transfection with miR-221/222 gene promoted the expression of endothelial markers, LDL uptake and tube-like formation. As expected, the PI3K/AKT signaling pathway was effectively activated during the endothelial differentiation of ADSCs when miR-221/222 genes were highly expressed. Furthermore, injection of miR-221/222 transfected ADSCs could significantly improve rat hindlimb ischemia evidenced by increase in blood flow and structural integrity, and reduce in inflammatory infiltration.
Conclusion
The results of the present study suggested that miR-221/222 is essential for endothelial differentiation in ADSCs, providing a novel strategy for modulating vascular formation and ischemic tissue regeneration.
Research on Implicit Intent Recognition Method Based on Prompt Learning
Authors: Liu Shuhua , Li Lanting , Fang Ming , Hung Chih-Cheng , Yang Shihao 
Published: July 2022

Abstract
As one of the core modules of the dialogue system, intent recognition plays an important role in human-computer interaction. Most of the existing intent recognition research is limited to simple, direct, and explicit intent recognitions. However, the natural human-computer interactions are flexible and diverse, and the expressions are often the euphemistic implicit intentions. Therefore, the implicit intent recognition brings new research challenges in this field. This paper pioneers a Chinese Implicit Intent Dataset CIID, which covers 7 common intents from different fields, and the data is the text containing the user's implicit intent. Based on this corpus, it is the first time prompt learning is employed for implicit intent recognition and by constructing a suitable prompt template, the model can get "relevant hints" to dig out the true intention of the user. Finally, this paper evaluates a range of classification models on CIID dataset. Experimental results show that the recognition rate of the proposed model is 97.6%, and achieves the state-of-the-art recognition accuracy. Furthermore, since it is difficult to collect the user's implicit intention data, this paper also explores the performance of these classification models on the CIID dataset with few-shot settings, and the experimental results show when the training data is reduced to 4.7%, the recognition rate of the proposed model can still keep 92.4%, which is significantly higher than other baseline models, the results further prove this proposed method is advanced and robust.
The Nonlinear Northern Hemisphere Stratospheric Temperature Response to External Radiative Forcing in Decadal Climate Simulations
Authors: Fahad Abdullah A. , Molod Andrea , Menemenlis Dimitris , Heimbach Patrick , Trayanov Atanas , Strobach Ehud , Coy Lawrence , Wargan Krzysztof 
Published: July 2022

Abstract

To predict the future climate on multiyear timescales, it is crucial to understand how the changing external radiative forcing (CO2 and Ozone) drives the climate and impacts the skill of intra-seasonal to multiyear climate prediction. In this study, we use a 1-degree configuration of the GEOS-MITgcm coupled general circulation model to understand the response to different levels of observed external forcing from past decades. We ran `perpetual' experiments for 1992, 2000, and 2020, each with their respective year’s external forcing. Results of the perpetual simulations showed that the Northern Hemisphere polar stratospheric temperature increases from 1992 to 2000, whereas it decreases from 2000 to 2020. We further conducted a 10-member ensemble of transient climate simulations for the 1992--2020 period with observed external forcing and found a similar positive temperature trend from 1992 to 2000 and a negative trend from 2000 to 2020. This is in contrast to the general expectation that the stratosphere cools as CO2 increases. A similar opposing pattern of temperature trends exists in reanalyses and CMIP6 historical simulations with a well-resolved stratosphere. Analysis of the results showed that the external forcing change during the years 1992-2000 increases the tropical diabatic heating, and intensifies the wave activity related meridional heat transport to the Northern Hemisphere mid to high-latitudes, which, in turn, increases the polar stratospheric temperature. In contrast, during the 2000-2020 period the meridional heat transport decreases, contributing to a decrease in the polar stratospheric temperature. The long-wave radiation change in these periods responds to the changing temperature and so doesn't play a significant role in driving them.
Genomic Investigations of Acute Hepatitis of Unknown Aetiology in Children
Authors: Breuer Judith , Morfopoulou Sofia , Buddle Sarah , Montaguth Oscar Torres , Atkinson Laura , Guerra-Assunção José Afonso , Storey Nathaniel , Roy Sunando , Lennon Alexander , Lee Jack , Williams Rachel , Williams Charlotte , Tutill Helena , Bayzid Nadua , Bernal Luz Marina Martin , Moore Catherine , Templeton Kate , Holden Matthew , Shah Priyen , Cooray Samantha , Voice Marie , Steele Michael , Fink Colin , Whittaker Thomas , Santilli Giorgia , Gissen Paul , Brown Rachel , Kaufer Benedikt , Reich Jana , Andreani Julien , Simmonds Peter , Alrabiah Dimah , Hereza Sergi Castellano , Andrade Catarina , Anderson Glenn , Kelgeri Chayarani , Waddington Simon , Diaz Juan Antinao , Hatcher James , De Surjo , Chiozzi Riccardo , Thalassinos Konstantinos , Jacques Thomas , Hoschler Katja , Talts Tiina , Celma Cristina , Gonzalez Suam , Gallagher Eileen , Simmons Ruth , Watson Conall , Mandal Sema , Zambon Maria , Chand Meera , Campos Luis , Martin Joanne , Thomson Emma , Ushiro-Lumb Ines , Levin Michael , Brown Julianne , Breuer Judith 
Published: July 2022

Abstract
Since the first reports of hepatitis of unknown aetiology occurring in UK children, over 1000 cases have been reported worldwide, including 268 cases in the UK, with the majority younger than 6 years old. Using genomic, proteomic and immunohistochemical methods, we undertook extensive investigation of 28 cases and 136 control subjects. In five cases who underwent liver transplantation, we detected high levels of adeno-associated virus 2 (AAV2) in the explanted livers. AAV2 was also detected at high levels in blood from 10/11 non-transplanted cases. Low levels of Adenovirus (HAdV) and Human Herpesvirus 6B (HHV-6B), both of which enable AAV2 lytic replication, were also found in the five explanted livers and blood from 15/17 and 6/9 respectively, of the 23 non-transplant cases tested. In contrast, AAV2 was detected at low titre in 6/100 whole bloods from child controls from cohorts with presence or absence of hepatitis and/or adenovirus infection. Our data show an association of AAV2 at high titre in blood or liver tissue, with unexplained hepatitis in children infected in the recent HAdV-F41 outbreak. We were unable to find evidence by electron microscopy, immunohistochemistry or proteomics of HAdV or AAV2 viral particles or proteins in explanted livers, suggesting that hepatic pathology is not due to direct lytic infection by either virus. The potential that AAV2, although not previously associated with disease, may, together with HAdV-F41 and/or HHV-6, be causally implicated in the outbreak of unexplained hepatitis, requires further investigation.