bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translational Research on Chagas Disease: Focusing on Drug Combination and Repositioning
Authors: André Vannier-Santos Marcos , Márcia Suarez-Fontes Ana , Almeida-Silva Juliana , Lifsitch Viçosa Alessandra , Aurora Chavez Perez Sandra , Marcel Hasslocher-Moreno Alejandro , Parreiras Estolano da Silveira Gabriel , Fernandes Portela Luciana , Magalhães Saraiva Roberto 
Published: July 2022

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major neglected disease endemic to Latin America, associated to significant morbimortality comprising a remarkable socioeconomic problem mainly for low-income tropical populations. The present chapter focuses translational research on Chagas disease, approaching drug combinations and repositioning, particularly exploiting the parasite oxidative stress by prospecting prooxidant compounds combined with antagonists of antioxidant systems, for developing low-cost and safe therapies for this infection. The pertinent literature on protozoal parasitic diseases is reviewed as well as on repurposing disulfiram aiming the combination with the Chagas disease drug of choice benznidazole. Both disulfiram and its first derivative sodium diethyldithiocarbamate (DETC) are able not only to inhibit p-glycoprotein, possibly reverting resistance phenotypes, but also to reduce toxicity of numerous other drugs, heavy metals, etc. Therefore, this innovation, presently in clinical research, may furnish a novel therapeutic for T. cruzi infections overcoming the adverse effects and refractory cases that impair the effectiveness of Chagas disease treatment.
Methods of Treating Autism: Holistic Approach to the Rehabilitation of People with the Spectrum of Autism
Authors: Trylinska-Tekielska Elzbieta , Pietraszewska Dorota , Stanisawska Iwona , Holak Ada 
Published: July 2022

In recent years, the autism spectrum in children has been increasingly recognized. Parental awareness and the knowledge of health professionals are critical to the early diagnosis of autistic disorders. The autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. The diagnosis of autism spectrum disorders is made on the basis of observation of behavior in three areas: social interaction, communication, and behavioral rigidity. The most common diagnosis is in children around 2–5 years of age, but the autism spectrum can be diagnosed at any age, also in adulthood. As the spectrum of autism varies, symptoms of autism may differ slightly from person to person. In order to exclude the presence of ASD in a child or adult, it is necessary to diagnose with the use of various tools, in which both a psychologist-diagnostician and a psychiatrist are involved. After diagnosis, the next important step is to include therapeutic and rehabilitation activities aimed at improving the functioning of the individual in disturbed areas. Lack of proper rehabilitation may lead to profound functional disturbances at a later age.
Entrepreneurial Competencies of Accountancy, Business, and Management Students in a Private Institution
Authors: Buitrago Lorelie , Polinar Mark Anthony , Delantar Alexander Franco , Buntigao John Lemuel 
Published: July 2022

Entrepreneurial competencies are considered a vital piece for aspiring entrepreneurs to pursue entrepreneurial ventures. The research aimed to examine the personal entrepreneurial competencies scores of accountancy, business, and management (ABM) students in a private institution. A quantitative method engaging in descriptive research was employed in the study. The study utilized Slovin's formula, with 187 ABM students responding. The data were analyzed using mean and ranking. The findings revealed that goal-setting and information-seeking garnered high scores and were rated first and second, respectively, with an interpretation of ‘strong traits’ and their strengths among the identified entrepreneurial competencies. Persuasion and networking and risk-taking obtained moderate scores and were ranked 9th and 10th, respectively, and accordingly labeled as inferior characteristics. The researchers concluded that a plethora of inside and outside-of-school activities related to entrepreneurship could enhance the information-seeking skills of students. It was also determined that students' self-awareness should be strengthened since taking risks is a key component of being a successful entrepreneur. Furthermore, the study suggested that increasing entrepreneurial activities both within and outside the campus will be valuable to ABM students in developing entrepreneurial competencies, particularly for characteristics belonging to the moderate level.
Optimum Stratification for Estimation of Mango Production in Himachal Pradesh
Authors: Rattan Ajay , Mahajan P. K. , Gupta R. K. , Chandel Ashu , Devi Sarita , Bansal Smriti , Vinay T. V. 
Published: July 2022

Mango plays an important role in socio-economic transformation of rural masses in the state. Proper assessment of area and production estimate is a prerequisite for effective horticulture planning Optimum stratification brings gain in precision in estimation of a characteristic of the population with limited time, money and human power. The primary data of area and production of mango of 325 mango orchardists of Himachal Pradesh were collected through well designed survey. The area under mango, auxiliary variable, was then subject to stratification in order to stratify the mango production, study variable. Four stratification methods 1) Equalization of Strata Total 2) Equalization of cumulative \(\sqrt{f(y) 3}\) 3) Equalization of cumulative \(\sqrt[3]{f(y)}\) and 4) Equalization of cumulative1/2[r(y)+f(y)] were used for stratification of area under mango production into varying number of strata L = 3, 4, 5, 6. From each strata a SRSWOR sample was drawn of size ni which was allocated by using proportional and Neyman allocation. After that estimate of mean and variance were computed for varying number of strata and for varying number of sample sizes n = 60, 90 and 120 allocated by proportional and Neyman allocation under these four stratification rules. The gain in precisions was also computed and is presented. It was found that \(\sqrt[3]{f(y)}\) for L = 6 and n = 120 yield minimum variance and maximum gain in precision. This showed that optimum stratification will lead efficient estimates and can be used for estimation of production in the state.
Proximate Analysis, Phytochemical Analysis, Colour Estimation, Antioxidant, Antibacterial Analysis, Shelflife Analysis of Sugarfree Burfi Optimization from Quinoa Seed Powder and Stevia
Authors: Jaiswal Sonali , Shankar Priyanka 
Published: July 2022

Quinoa seed powder and stevia has several health benefits. stevia has been naturally incorporated with sugar making it beneficial for diabetic patients. Burfi was an Indian popular sweet with harmful content and qualities. So, burfi was prepared using quinoa seed powder and stevia to incorporate benefits of plant compounds quercetin and kaempferide with the help of physicochemical analysis, proximate analysis, phytochemical analysis, antioxidant analysis shelf-life analysis and colour estimation analysis. The moisture content of optimized burfi and control burfi was obtained to be 15-20% percent respectively. The protein content of optimized burfi and control burfi have value 18.97-20.286% percent respectively. The fat content of optimized burfi and control burfi were 18.630-21.972% percent respectively. The ash content of optimized burfi and control burfi 3.4-4% percent respectively. The Titrable acidity of optimized burfi and control burfi were 1.035-1.16% percent respectively. The carbohydrate of optimized burfi and control burfi were 31.66-25.708% percent respectively. The crude fiber of optimized burfi and control burfi were 0-1.25% percent respectively. The calcium of optimized burfi and control burfi were 571-520 mg respectively. The pH of optimized burfi and control burfi were 7.99-8.03 pH respectively etc. Antioxidant activity was analysed using the in standard spectrophotometer method. Optimized quinoa burfi was investigated for their in-scavenging activities using 1,1-diphenyl-1-2 picrylhydrazyl (DPPH). Then check the Shelflife at 10 days. T0 - 3.27×102, T1 - 3.36×102, T2 - 4.72×102. Coliform was 0. The quinoa seed powder expands DPPH searching action up to 43.13 µg of focus Other khoa burfi making it good for diabetic and ordinary individuals. The research was done at the research centre of food science examination Laboratory, Babasaheb Bhimrao Ambedkar University. Lucknow (INDIA).
A Proposal for a Novel Scoring System for Triage of Acutely Poisoned Patients at Tanta University Poisoning Treating Center, Egypt
Authors: Elfatah Asmaa G. S. Abd , Ghonem Mona M. , Wahdan Amira A. , El –Gohary Mona S. A. 
Published: July 2022

Background: Poisoning is defined as exposure of an individual to a potentiality harmful substance either by inhalation, skin contact, ingestion, or injection.
Aim of the Work: This study aimed to develop and validate a novel scoring system using vital signs, arterial blood gases (ABG) and consciousness level as a tool of triage for evaluation and outcome prediction of acutely poisoned patients.
Methods: The current prospective cohort study was conducted on patients with acute poisoning who were admitted at Tanta University Poisoning Treating Center (TUPTC) throughout a period of start of April 2020 to the end of June 2021. For each patient, age, sex, and toxicological characteristics were obtained. Clinical examination and routine laboratory investigations were also done.
Results: Significant differences were observed between survivors and non-survivors in the derivation group (444 patients) regarding systolic blood pressure, diastolic blood pressure, respiratory rate, temperature, blood pH, PaCO2, serum HCO3, and O2 saturation. Using univariate and multivariate regression analysis SBP, serum HCO3, and O2 saturation were valid to construct the prediction score at cut off ≤100 mmHg, ≤16.6 mEq/L, and ≤93% respectively. Variables were given points and the score has range from 0 (the best score) to 3 (the worst score). The discrimination power in the derivation group at cut-off point >1 was excellent (AUC: 0.925) with 91.3% sensitivity and 94.9% specificity. Additionally, the discrimination power in the validation group (140 patients) at cut-off point >1 was excellent (AUC: 0.965) with 87.5% sensitivity and 93.8% specificity.
Conclusion: This proposed score could be considered a simple and excellent tool for triage to identify acutely poisoned patients who are at risk of mortality. In addition, it is validated and so it could be used in other populations.
Effect of Encapsulated Human Islet Cells Implantation on Insulin Dependency in Diabetes Mellitus: An Innovative Approach
Authors: Usmani Hina , Kant Ravi , Mirza Anissa Atif , Meshram Ravi Prakash 
Published: July 2022

Background: Globally, the number of diabetic patients has quadrupled in last 30 years and diabetes mellitus (DM) is among the major causes of death with rank 9 worldwide. Approximately there is 1 patient with DM in 11 people worldwide. Asia is among the major areas of where T2DM is rapidly emerging into global epidemic. In Asian countries China and India are top two epicenters for this rapidly emerging epidemic. Studies have shown that without immunosuppression in diabetic animal model, normoglycemia is maintained after implantation of encapsulation technique (macro/micro-encapsulation) containing islets at different sites in body. If this study could work well, it will be possible to implant a capsule in diabetic patient reducing dependency on insulin from outside using other methods like multi-layer-by-layer encapsulation. Purpose of this study will be to determine whether encapsulation of pancreatic β-cell in subcutaneous region could protect human islets from rejection and autoimmune destruction in diabetic patients, by overall decreasing insulin dependency in T2DM patients without immunosuppression.
Methods and analysis: Protocol will be based on multi-layer-by-layer encapsulation procedure.
Discussion: To our knowledge, there are no such studies which are performed in phases making this study to be a best example of evidence based protocol. Appropriate subgroup analysis has been planned while performing animal experimentation. Routine postoperative monitoring have been planned to ensure Ethics and dissemination. Analysis of encapsulation in different conditions i.e. in-vitro and in-vivo will provide diverse data on effects of encapsulated islet cells on different environmental conditions. In-vitro data will be compared with in-vivo data in order to find out detailed successful results. According to this protocol, if we will be able to develop encapsulated human islet cells that will produce insulin and decrease insulin dependency then this study will be a novel interventional research to decrease burden of insulin therapy in low income population such as of India.
Multi‐Level Anti‐Counterfeiting and Optical Information Storage Based on Luminescence of Mn‐Doped Perovskite Quantum Dots
Authors: Feng Xuying , Sheng Yuhang , Ma Kewei , Xing Fangjian , Liu Cihui , Yang Xifeng , Qian Hongqiang , Zhang Shude , Di Yunsong , Liu Yushen , Gan Zhixing 
Published: July 2022

AbstractTraditional fluorescent anti‐counterfeiting labels can be easily cloned due to the lack of sufficient security. Therefore, multilevel anti‐counterfeiting techniques with higher security need to be constantly explored. This study reports a multilayer composite structure containing Mn doped CsPbCl3 (Mn:CsPbCl3) perovskite quantum dots (PQDs) layer and CsPbBr3 PQDs layer. The encrypted information is patterned on the Mn:CsPbCl3 PQDs layer with weak orange fluorescence, which is concealed by the brighter green fluorescence of CsPbBr3 PQDs at the upper layer. Based on the well‐separated photoluminescence (PL) peak positions, inverse PL temperature‐dependences and distinct PL lifetimes of these two PQDs, the encrypted information can be read out by adding cut‐off filter, heating and using ultrafast camera (UCA)/pulsed excitation (PE). This multilevel anti‐counterfeiting label significantly increases the difficulties of imitation meanwhile no expensive equipment is required for the verification of authenticity. Moreover, two bits of binary numbers that can be represented by dual emissions of the Mn:CsPbCl3 PQDs by changing the doping content, which significantly increases the information storage capacity, are also demonstrated.
Acute myeloid leukemia and dilated cardiomyopathy in a pediatric patient with D‐2‐hydroxyglutaric aciduria type I
Authors: Murphey Kristen , George Paul E. , Pencheva Bojana , Porter Christopher C. , Wechsler Stephanie Burns , Gambello Michael J. , Li Hong 
Published: July 2022

AbstractD‐2‐hydroxyglutaric aciduria (D‐2‐HGA) is a rare neurometabolic disease with two main subtypes, caused by either inactivating variants in D2HGDH (type I) or germline gain of function variants in IDH2 (type II), that result in accumulation of the same toxic metabolite, D‐2‐hydroxyglutarate. The main clinical features of both are neurologic, including developmental delay, hypotonia, and seizures. Dilated cardiomyopathy is a unique feature thus far only reported in type II. As somatic variants in IDH2 are frequently identified in several different types of cancer, including acute myeloid leukemia (AML), a link between cancer and this metabolic disease has been proposed; however, there is no reported cancer in patients with either type of D‐2‐HGA. Murine models have demonstrated how D‐2‐hydroxyglutarate alters metabolism and epigenetics, a potential mechanism by which this metabolite may cause cancer and cardiomyopathy. Here, we report the first case of both AML and dilated cardiomyopathy in a pediatric patient with D‐2‐HGA type I, who was treated with an anthracycline‐free regimen. This report may expand the clinical spectrum of this rare metabolic disease and provide insight on long‐term surveillance and care. However, this case is complicated by the presence of a complex chromosomal rearrangement resulting in a 25.5 Mb duplication of 1q41 and a 2.38 Mb deletion of 2q37.3. Thus, the direct causal relationship between D‐2‐HGA and leukemogenesis or cardiomyopathy warrants further scrutiny.
Formation of NaF‐Rich Solid Electrolyte Interphase on Na Anode through Additive‐Induced Anion‐Enriched Structure of Na+Solvation
Authors: Wang Huaping , Zhu Chunlei , Liu Jiandong , Qi Shihan , Wu Mingguang , Huang Junda , Wu Daxiong , Ma Jianmin 
Published: July 2022

AbstractHigh‐capacity sodium (Na) anodes suffer from dendrite growth due to the high reactivity, which can be overcome through inducing a stable NaF‐rich solid electrolyte interphase (SEI). Herein, we propose an additive strategy for realizing the anion‐enriched structure of Na+solvation to obtain a NaF‐rich SEI. The electron‐withdrawing acetyl group in 4‐acetylpyridine (4‐APD) increases the coordination number of PF6−in the Na+solvation sheath to facilitate PF6−to decompose into NaF. Thus, the NaF‐rich SEI with high mechanical stability and interfacial energy is formed to repress the growth of Na dendrites. With the 4‐APD‐contained electrolyte, the symmetric Na||Na cells show excellent cycling performance over 360 h at 1.0 mA cm−2. Meanwhile, excellent stability is also achieved for Na||Na3V2(PO4)2O2F full cells with high Coulombic efficiency (97 %) and capacity retention (91 %) after 200 cycles.
Recent Progress in the Construction of Artificial Nanochannels for Biosensing
Authors: Li Chonglu , Guan Xiaofang , Sun Yao , Li Junrong 
Published: July 2022

AbstractThere are many biological channels in nature that play a vital role in life process. Inspired by biological nanochannels, researchers have developed artificial nanochannels for basic research and practical applications. In recent years, artificial nanochannels have not only been constructed for various ionic, small‐molecule and macromolecular biosensors, but have also been used to investigate the transfer behavior of ions and molecules. This review discusses the basic principles and ionic current characteristics of artificial nanochannels, deliberates on several functionalization approaches for artificial nanochannels, and highlights the applications in ion and small molecule detection. Importantly, this review provides the insight and perspective for the future development of artificial nanochannels.
Sustainability in large food and beverage companies and their supply chains: An investigation into key drivers and barriers affecting sustainability strategies
Authors: Adams David , Donovan Jerome , Topple Cheree 
Published: July 2022

AbstractFood and beverage companies have a very significant environmental and social impact, and this has become a global issue. The purpose of this study is to evaluate the drivers and barriers to implementing sustainability in large food and beverage companies and their supply chains. A total of 21 semistructured interviews were undertaken with 16 large food and beverage companies operating in Australia, including 11 multinationals. Institutional theory and extended resource‐based view (ERBV) were applied to evaluate the companies' responses to the external pressures that they faced. The lack of a government regulatory and environmental framework was seen as a major barrier, while top management commitment was generally strong across the sample companies and was seen as a key internal driver. In order to develop an effective sustainability strategy, it is important that a company understands the drivers and barriers to sustainability implementation so that the appropriate actions can be taken. To the best of the author's knowledge, this is first time that the drivers and barriers to sustainability of large food and beverage manufacturers have been evaluated.
Bio‐functional hydrogel with antibacterial and anti‐inflammatory dual properties to combat with burn wound infection
Authors: Xiong Yahui , Xu Yingbin , Zhou Fei , Hu Yanke , Zhao Jingling , Liu Zhonghua , Zhai Qiyi , Qi Shaohai , Zhang Zhaoqiang , Chen Lei 
Published: July 2022

AbstractBurn infection delays wound healing and increases the burn patient mortality. Consequently, a new dressing with antibacterial and anti‐inflammatory dual properties is urgently required for wound healing. In this study, we propose a combination of methacrylate gelatin (GelMA) hydrogel system with silver nanoparticles embed in γ‐cyclodextrin metal–organic frameworks (Ag@MOF) and hyaluronic acid‐epigallocatechin gallate (HA‐E) for the burn wound infection treatment. Ag@MOF is used as an antibacterial agent and epigallocatechin gallate (EGCG) has exhibited biological properties of anti‐inflammation and antibacterial. The GelMA/HA‐E/Ag@MOF hydrogel enjoys suitable physical properties and sustained release of Ag+. Meanwhile, the hydrogel has excellent biocompatibility and could promote macrophage polarization from M1 to M2. In vivo wound healing evaluations further demonstrate that the GelMA/HA‐E/Ag@MOF hydrogel reduces the number of the bacterium efficiently, accelerates wound healing, promotes early angiogenesis, and regulates immune reaction. A further evaluation indicates that the noncanonical Wnt signal pathway is significantly activated in the GelMA/HA‐E/Ag@MOF hydrogel treated group. In conclusion, the GelMA/HA‐E/Ag@MOF hydrogel could serve as a promising multifunctional dressing for the burn wound healing.
A generational comparison for unfavorable cancer of unknown primary in a single institute over 20 years
Authors: Tang Cheng‐Yu , Hang Jen‐Fan , Hung Yi‐Ping , Chiu Nai‐Chi , Lai Jiun‐I , Chen Ming‐Huang , Liu Chun‐Yu , Yang Muh‐Hwa , Chao Yee , Chang Peter Mu‐Hsin 
Published: July 2022

AbstractBackgroundThe prognosis of unfavorable cancer of unknown primary is extremely poor. This is the first report to compared the treatment results between generations of CUP and examined prognostic factors.MethodsThis retrospective single‐center cohort study enrolled 68 patients with newly diagnosed unfavorable cancer of unknown primary at Taipei Veteran General Hospital from 2017 to 2020 as study cohort and 167 patients from 2000 to 2009 as historical cohort.ResultsThe median overall survival was 4.3 months in the study cohort (95% CI, 2.7–6.2 months) and 4.5 months in the historical cohort (95% CI, 3.0–5.5 months; p = 0.858). Eleven patients in the study cohort received immunotherapy. The disease control rates were 45%. Multivariate analysis showed that an Eastern Cooperative Oncology Group score > 1 and a C‐reactive protein level > 1 correlated with poor survival. A new prognostic stratification model was constructed by using Eastern Cooperative Oncology Group score and C‐reactive protein values. The good‐, intermediate‐, and poor‐risk groups had distinct median overall survival of 18.3, 7.0 and 1.2 months, respectively (area under the curve, 0.817; p < 0.001).ConclusionThe outcome of unfavorable cancer of unknown primary has not changed much over the last 20 years. The application of a new prognostic stratification model can further stratify unfavorable cancer of unknown primary.