bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Frontiers in the Discovery and Development of PROTACs
Authors: Barghout Samir H. 
Published: April 2022

Abstract:
Proteolysis targeting chimeras (PROTACs) are an emerging class of targeted protein degraders that coopt the intracellular degradation machinery to selectively deplete their respective targets. PROTACs act as bifunctional degraders that comprise ubiquitin E3 ligase- and target-binding moieties connected by chemical linkers with appropriate physicochemical properties. Through this bivalent structure, PROTACs induce the degradation of their targets via proximity-based pharmacology. Compared to conventional inhibitors, PROTACs exhibit superior pharmacologic properties with respect to efficacy, potency, selectivity, durability of response, and efficacy against undruggable proteins. Over the last few years, the scientific community has witnessed significant endeavors to advance this field and expand the armamentarium of PROTACs. In this perspective, we highlight these advances with an emphasis on emerging PROTAC variants, PROTACtability and degradability of protein targets, expression-guided PROTACs, multivalent PROTACs, preclinical resistance, candidates evaluated in clinical trials, and prospects for the use of PROTACs as a therapeutic modality.
The Effects of Amino Acids, Phenols and Protein Hydrolysates as
Biostimulants on Sustainable Crop Production and Alleviated
Stress
Authors: Shahrajabian Mohamad Hesam , Cheng Qi , Sun Wenli 
Published: April 2022

Abstract:
Biostimulants which contain substances or products, including natural compounds,
special formulations and microorganisms have gained considerable attention as
sustainable methods for heavy metal detoxification, stimulating natural toxins, controlling
diseases and pests, and increasing both water and nutrient efficiency. Biostimulants are important
products in modern agriculture, which are composed of different heterogeneous
classes of compounds with a broad spectrum of action to increase both qualitative and
quantitative productions. Amino acids can be useful in stress defense, photosynthesis, for
increasing nutrient uptake, pollination and fruit formation, and as precursors to hormones
and growth parameters. Amino acids are considered as precursors and constituents of proteins,
which are well-known for the stimulation of cell growth. Because they are the basic
building blocks of proteins, amino acids are very important in plant growth, development
and metabolite synthesis. One of the diverse, notable and large group of secondary metabolites
is phenolic compounds, which have important function in regulation of the plants’
physiological activities, oxidation-reduction processes, and photosynthesis. Protein hydrolysates
contain amino acids and peptides, one of the most important kinds of biostimulants.
Protein hydrolysates have a notable capability to increase crop performance, particularly
under environmental stress conditions. This review article is aimed to introduce and find
more about the roles of different types of biostimulants in plant growth and final yield production,
leading to sustainable agriculture.
A novel optimal approach for control law of multi-rate systems with different rate operations
Authors: Roosta Alireza , Soltanimehr Alireza 
Published: April 2022

Abstract
The main purpose of this study is to propose a method to achieve optimal response and performance of the multi rate systems in existence of different sampling rates and to avoid data losses in such systems. In this paper, a new approach based on the multi-rate digital system is proposed. Based on this method, we will be able to maintain optimal performance of these systems without losing data, in addition to establishing connections between subsystems with different sampling rates. By the proposed method, not only the effect of different sampling rates in multi-rate systems is ignored, but also, we can connect subsystems with different rate operations without compromising system performance and data loss which simplified system design and sensor selection by the digital system designers. This means the designer can choose any sensor without concerning about the sampling rate and the operation rate of the system and matching them together. Finally, a guided missile with different sampling rates between the seeker, autopilot, guidance law and the output feedback are simulated and its effective performance in pursuit, hitting and smooth motion toward the target in a motion scenario is shown.
Pengembangan Buku Ajar Berbasis Scientific Approach Pada Mata Pelajaran Akuntansi Keuangan Kelas XI Semester Genap SMK Negeri 1 Sooko Mojokerto
Authors: Febriana Nana , Listiadi Agung 
Published: April 2022

The purpose of this study to produce and analyze the results of advisability and student responses to the textbook based on scientific approach on financial accountiingg subjects. This textbook was tested by material experts, linguists, and graphic, tested on 20 XI grade Financial Accounting students at Sooko Mojokerto State Vocational School. The research method used 4D development model by Thiagarajan without being spread. This study gets results from the validation of material experts by 91.70%, validation of linguists 80%, graphic validation by 86.67% and students responses by 96%. The recapitulation was successfully obtained 88.59% and it can be concluded that the textbooks developed were very feasible to use.
Pengembangan Bahan Ajar E-book Pada Materi Siklus Akuntansi Perusahaan Jasa Sebagai Pendukung Pembelajaran Saintifik Kelas X Akuntansi Di SMK Negeri 2 Tuban
Authors: Juniors Reynaldo , Susilowibowo Joni 
Published: April 2022

In the 2013 revised curriculum, teaching and learning activities require student to be more active in the learning process. In addition, teacher is required to have teaching materials that linked to technological advances that refer to basic competencies and scientific approach, adjusted for the student needs. This research aims to create a product in the form of an e-book for teaching materials and analyze the feasibility of e-book teaching materials about service company accounting cycle. This research used 4D model (define, design, develop and disseminate) that developed by Thiagarajan, Semmel, and Semmel, but this research is only carried out until the develop stage. The research instrument used by researchers in this article is an open poll which consists study sheet of media expert, graphic expert and linguist as well as enclosed that also consists validation sheet of media expert, graphic expert and linguist. The analysis technique used by the researcher consists of analysis of study sheets, which will be analyzed descriptively along with validation sheet analysis that will be analyzed using Likert scale as stipulation in the research provisions. The assessment results obtained from material expert by 89.51%, it has a splendid eligibility level. 92.66% from linguist and 96.01% from graphic expert are showing also a superior eligibility level. Thus, from the three components, it was obtained average of 92.72% with the splendid eligibility level. This research concludes that e-book, that has developed with a scientific approach, that contain service company accounting cycle material, is stated very worthy to be used in teaching learning activities.
ANALISIS KESULITAN GURU MATEMATIKA SMP NEGERI 1 LENDAH DALAM MENERAPKAN PEMBELAJARAN ONLINE PADA MASA PANDEMI COVID-19
Authors: Ugi Amri Ma'rufi  , Irham.taufiq  , Esti Harini  
Published: April 2022

Penelitian ini merupakan penelitian kualitatif deskriptif. Tujuan penelitian ini adalah untuk mengetahui kesulitan apa yang dialami guru matematika SMP dalam menerapkan pembelajaran online serta solusi yang dapat diterapkan untuk mengurangi kesulitan tersebut. Penelitian ini dilakukan di SMP Negeri 1 Lendah. Subjek penelitian adalah 4 guru matematika. Pengumpulan data dilakukan dengan cara observasi, wawancara serta dokumentasi. Hasil penelitian menunjukkan bahwa kesulitan guru matematika dalam menerapkan pembelajaran online pada masa pandemi covid-19 adalah masih kurangnya pemahaman mengenai IT, keaktifan peserta didik yang masih rendah, kepemilikan handaphone yang belum tercukupi serta sinyal yang kurang mendukung. Selain itu, solusi yang dapat dilakukan untuk mengurangi kesulitan tersebut antara lain dengan meningkatkan wawasan guru dalam bidang IT, pelaksanaan pembelajaran tatap muka terbatas dan kerjasama seluruh warga sekolah, guru maupun peserta didik. Saran dari penelitian ini adalah guru harus meningkatkan kemampuan IT, sekolah harus bekerjasama dengan pihak orang tua, peserta didik harus meningkatkan keaktifan dalam pembelajaran dan peneliti dapat menjadikan penelitian ini sebagai referensi dalam penelitian yang berhubungan dengan efektivitas pembelajaran online.
Kolaborasi Guru dan Orang Tua dalam Pembelajaran Full Day School pada Masa Pandemi Covid-19
Authors: Maruddani Raoda Tul Jannah , Sugito Sugito 
Published: April 2022

Program sekolah sepanjang hari (full day school) menjadi program pendidikan alternatif bagi anak usia dini dengan orang tua pekerja. Penelitian ini bertujuan untuk mengeksplorasi pola kolaborasi pembelajaran antara guru dan orang tua di TK Al- Fatih Kids Kota Jambi pada program sepanjang hari (full day school) selama masa darurat covid-19. Penelitian ini menggunakan kuallitatif deksriptif dengan pendekatan studi kasus (case study) dengan subjek penelitian adalah 7 orang tua siswa, 2 guru kelas, serta 3 guru pendamping di full day school. Teknik pengumpulan data dalam penelitian ini adalah wawancara. Berdasarkan hasil penelitian yang telah dilakukan, kolaborasi pembelajaran antara guru dan orang tua pada program full day school yaitu terdiri dari komunikasi aktif antara guru dan orang tua melalui Whatsapp Group ataupun via chat pribadi, kerja sama antara guru dan orang tua berupa pendampingan belajar anak dari rumah, menyediakan bahan yang diperlukan anak, memfasilitasi tempat belajar dirumah, dan keterlibatan orang tua pada keberlangsungan aktivitas pembelajaran yang diadakan oleh sekolah dan rutin mengirimkan laporan belajar ketika anak di rumah.
ERKEN BİR KARNAVALESK ROMAN DENEMESİ: YENİŞEHİRDE BİR ÖĞLE VAKTİ
Authors: ÇETİN BAYCANLAR Sema 
Published: April 2022

1960’lı yıllarda yazmaya başlayan Sevgi Soysal’ın edebi yaşamı boyunca farklı edebi türlerde verdiği anlatıların edebiyat dünyasında merak uyandıran aynı zamanda eleştirilen yönlerinden biri de içerik ve biçim açısından yeniliğe olan ilgisidir. Soysal’ın hikâye ile roman arasında sıkışıp kalmaktan ziyade iki edebi türün olanaklarını sınırsızca kullanmaya olan merakı ve cesareti dikkat çekicidir.
Yenişehir’de Bir Öğle Vakti romanı da yazıldığı yıllarda anlatım tutumu ve içeriğiyle çağdaşı romanlardan ayrılan bir eser olarak değerlendirilir. Soysal, eserinde aynı mekân içinde toplumun sosyo-ekonomik olarak farklı kesimlerini temsil eden, gelişigüzel bir kalabalığın içinden roman kişilerini seçer ve onları ana hikâyenin içine yerleştirmektense her birinin hikâyesini ayrı ayrı yazmayı tercih eder.
Mikhail Bakhtin, romanda karnavelesk unsurları besleyen ve gerçekleştiren unsurları geniş bir yelpaze içinde ele alır. Bakhtin’in değerlendirmelerinin ışığında grotesk gerçeklik, karnaval ruhu, diyalojik unsurlar gibi başlıklar, herhangi bir romanın karnavalesk romanla kurduğu ilişkiyi tanımlamakta ayrıt edici unsurlar taşır. Bu bağlamda Yenişehir’de Bir Öğle Vakti, karnaval ruhunu yansıtması, grotesk gerçekliğin bedene-canlılara ait söylemi ve diyalojik unsurlar açısından kısmen de olsa bu roman türünün özelliklerini taşır.
Bu çalışmada, Türk edebiyatında daha çok modernist ve postmodernist roman özelinde ele alınan karnavalesk unsurların erken bir örnek olarak Yenişehir’de Bir Öğle Vakti’nde değerlendirilmesini mümkün kılan unsurlar üzerinde durulacaktır.
Timing of Clinical Interventions in Patients With Duchenne Muscular Dystrophy: A Systematic Review and Grading of Evidence
Authors: Landfeldt E. , Ferizović N. , Buesch K. 
Published: April 2022

Background: Clinical medical management guidelines of Duchenne muscular dystrophy (DMD) emphasize prevention and early identification and treatment. Objective: The objective of our study was to review, synthesize, and grade published evidence of the impact of the timing of clinical interventions in DMD. Methods: We searched PubMed, Embase, and the Cochrane Library for records published from inception up until November 19, 2021, reporting evidence of the impact of the timing of clinical interventions in DMD. We assessed the quality of evidence using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework. Results: We included 12 publications encompassing 1,623 patients with DMD from seven countries (Australia, France, Germany, Italy, Japan, the United Kingdom, and the United States of America). Six (50%) studies reported evidence of an impact of the timing of initiation of glucocorticoids on loss of ambulation, cardiomyopathy, fractures, forced vital capacity, and height and BMI; four (33%) of cardiac medication (i.e., angiotensin-converting enzyme inhibitors, β-blockers, and eplerenone) on left ventricular size and function and survival; one (8%) of lower limb surgery on motor quotient and loss of ambulation; and one (8%) of ataluren on lower extremity and motor function. The overall quality of the body of evidence was low. Conclusion: While there is a clinical rationale for anticipatory diagnostic and therapeutic strategies, evidence of the impact of the timing of initiation of treatments in patients with DMD is still emerging. Further research of this topic is warranted to inform treatment guidelines in this indication.
Bithiophene derivative induced apoptosis and suppression of Akt pathway in mouse leukemic model
Authors: Algharib Ali Samy , Shanab Gamila Mohamed-Labib , Abdel-Ghaffar Abdel-Rahman Badr , Ismail Mohamed Ahmed , Mohamed Rania Hassan 
Published: April 2022

BACKGROUND: Bithiophene derivatives show a promising anti-cancer potential. We previously showed that Bithienyl Fluorobenzamidine (BFB) has an anti-proliferative effect against several leukemia cell lines. Acute myeloid leukemia (AML) accounts for 18% of the total leukemia cases worldwide with heavier burden during the past 30 years. Therefore, the main aim remains the discovery of safe and effective medications. OBJECTIVE: The current research aims to investigate the anti-cancer efficacy of BFB and its effect on the apoptosis in the 7,12-Dimethylbenz[a]anthracene (DMBA) induced AML in mice. METHODS: AML was induced in mice by DMBA and then treated by 2 different doses of BFB. After BFB treatment, the hematological and histological pattern changes was examined. Furthermore, the molecular effect of BFB on apoptosis, cell cycle markers and Protein kinase B (Akt) pathway was examined using qPCR, Western blotting and ELISA. RESULTS: BFB treatment ameliorates leukemia histological and hematological markers significantly, despite non-significant changes in normal mice. This improvement exhibits cell cycle arrest and apoptosis induction, represented by elevation of tp53/p53, p21/p21, Caspase3 and downregulation of ckk1/Cdk1 in the bone marrow, as well as Akt pathway suppression. CONCLUSIONS: Our results establishes BFB as a promising therapeutic candidate against AML through cell cycle arrest, apoptosis induction and Akt pathway modulation.
I am a Muslim and Asian Woman in the United Kingdom
Authors: Pazil Nur Hafeeza Ahmad 
Published: April 2022

Utilizing an autoethnographic stance and method, this article is based on my experiences as a Malaysian postgraduate student in the United Kingdom. I draw upon my memories of dealing with Islamophobia and xenophobia while living there, as a Muslim and Asian woman. Anti-Asian sentiment and xenophobia can be experienced in many forms, ranging from feelings of discomfort to verbal insults and direct confrontation. As a visible Muslim and Asian woman, I reflect upon my own experience as a victim of verbal abuse on different occasions. This article offers an intersectional perspective taking into account interconnected and overlapping factors, such as gender, ethnicity and religion, to examine the multi-layered issues and challenges as an international student. I highlight the challenges in expressing and negotiating my intersectional identities while living temporarily abroad. Therefore, this article is very important to raise awareness about Islamophobia as well as inadvertent or deliberate xenophobia towards Asian communities.
Influence of Clinical Pharmacist intervention on the Quality of Life of Anemic Patients with Chronic Kidney Diseases in the Hemodialysis Setting in Kirkuk-Iraq.
Authors: Bushra Hassan Marouf  , Intisar Ahmed Yusif  , Raad Hassan Najim  
Published: April 2022

Purpose
To assess the impact of pharmacist intervention on the health related quality of life (QoL) among anemic patients with chronic kidney diseases in a hemodialysis center.

Methods
A single blind, randomized control study was carried out at the hemodialysis center of Kirkuk Hospital in Kirkuk-Iraq. The patients were randomized into two groups; interventional group received clinical pharmacist services delivered by a qualified registered pharmacist and non-interventional group received usual hospital care and. The pharmacist proposed clinical interventions at the level of patients, drugs, hospital level to improve the patient’s quality of life. The impact of clinical pharmacist’s intervention on improving quality of life of patients was assessed by using the Rand 36-Item Short Form Health Survey questionnaire. The assessment of the QoL was carried out for both groups for a total of 4-month follow-up; at baseline, day 60 and day 120.
Results
A total number of 120 patients were recruited from the hemodialysis centers and 1437 interventions were applied for interventional group (n=60), 41.4% at the drugs level, 51.1% at the patient level and 7.5% at the hospital and administrative level. The health related QoL scores were significantly improved over time in the domains noticed with regard to the “physical functioning, general health, emotional role” of interventional group compared to the baseline and non-interventional group with conventional hospital care with P <0.05.
Conclusion
Interventions provided by the pharmacist had a positive impact on QoL of anemic patients in the hemodialysis center of the city.
Lipid Profile Changes in Pregnant Women with Pre-Eclampsia and Their Correlation with Severety of Pre-Eclampsia
Authors: Niran Kamel*, Wasan Munim  , Wasan Munim  , Alaa Raheem Kareem  , Mustafa Rasool Hussein Aal-Saleh  , Mohammed Luay Subhi  , Sarah Abdulkareem Ali Al-Dujaili  
Published: April 2022

Objectives: To find out whether there is a lipid profile changes in pregnant women with preeclampsia and if we can use these lipid profile changes as markers of the severity of preeclampsia (for follow up to avoid leaving the patient reaching ecplamptic stage).

Design: A prospective case-control study.
Setting: AL- Kadhimiya Teaching hospital/department of Obstetrics and Gynecology.
Materials and Methods: The study included 120 pregnant women in the third trimester. They were divided into three groups. The study group consists of 60 preeclamptic and eclamptic women, 25 women had mild pre-eclampsia and 35 women with severe preeclampsia. The control group consists of 60 normotensive pregnant women. Blood sample was drown after 8-10 hours fasting. Triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol levels were measured.
Results: Triglyceride and VLDL-C level of severe Preeclampsia group and mild Preeclampsia group was higher than the control group, but the difference between the severe PE group and the control group was statistically significant (p<0.05). Serum cholesterol in the severe PE group was significantly higher than in mild PE group and in the control group (p<0.05). LDL-C and HDL-C levels were determined similarly in all groups (p>0.05). A highly significant positive correlation between the level of proteinuria and serum cholesterol levels, LDL-C, TG and VLDL-C levels. While there was significantly negative correlation between proteinuria and HDL-C levels. Also, a significant positive correlation between the systolic-tension and serum cholesterol levels, TG, VLDL-C levels and among the diastolic-tension and with LDL-C, TG, VLDL-C levels.
Conclusion: Changes in levels of lipid profile are related with preeclampsia, especially with severe preeclampsia.
PEMETAAN ZONASI TINGKAT RISIKO COVID-19 MENGGUNAKAN METODE K-MEANS CLUSTER BERBASIS WEBGIS DI KOTA BOGOR
Authors: Andi Irawan  , Hermawan Erwin , Riana Freza 
Published: April 2022

Coronaviruses atau disebut dengan COVID-19 merupakan virus yang menyerang sistem pernafasan. Virus ini berkembang sangat pesat dalam penularan dari manusia ke manusia lainnya. Angka penularan di Indonesia terbilang cukup tinggi, salah satu wilayah yang terpapar COVID-19 adalah Kota Bogor. Kota bogor menduduki status beresiko sedang, dimana pada bulan maret tahun 2020 hingga agustus tahun 2021 jumlah kasus positif yang terkonfirmasi sebanyak 35.583 kasus, sedangkan untuk pasien yang terkonfirmasi positif sembuh mencapai 35.062 orang, dan pasien yang terkonfirmasi positif meninggal sebanyak 521 orang. Dari data yang diperoleh dari Dinas Kesehatan Kota Bogor dinamika harian virus COVID-19 terus menunjukan peningkatan. Peta sebaran zonasi COVID-19 untuk wilayah Kota Bogor pada tingkat kelurahan masih belum tersedia. Oleh karena itu penelitian ini memanfaatkan sistem informasi geografis (SIG) dalam memetakan zona COVID-19 dengan menerapkan metode Kmeans Cluster untuk mengklasterisasi daerah sebaran virus COVID-19. Pengelompokan dilakukan berdasarkan parameter jumlah kasus positif dan pasien meninggal. Penelitian ini menghasilkan peta zonasi COVID-19. Berdasarkan pengujian, jumlah klaster yang direkomendasikan adalah 3 klaster. Dimana untuk pembagian zonasi berdasarkan Satgas COVID-19 terbagi diantaranya, merah untuk zona tinggi, orange untuk zona sedang, kuning untuk zona rendah, dan wilayah yang tidak terpapar kasus COVID-19 masuk kedalam kategori hijau atau tidak ada kasus. Hasil dari penelitian ini adalah peta zonasi COVID-19 yang ditampilkan dalam bentuk WEBGIS.
PERANCANGAN APLIKASI PERJALANAN DINAS ONLINE YAYASAN PENDIDIKAN TELKOM
Authors: Gilang Gemilang Ramadhan Putra  , Wahyu Ari Purno 
Published: April 2022

Perjalanan Dinas di Yayasan Pendidikan Telkom merupakan salah satu kegiatan perjalanan yang harus dilaksanakan oleh pegawai atas perintah Dewan Pengurus / Pimpinan Tertinggi / Pimpinan Lembaga / Pimpinan Unit yang meliputi perjalanan karena tugas, pelatihan, seminar, konferensi, studi banding, kunjungan kerja, dan perjalanan dinas khusus. Dalam proses operasionalnya, perjalanan Dinas di YPT masih menggunakan surat perjalanan dinas versi cetak untuk mendapatkan persetujuan, perhitungan biaya perjalanan dinasnya dan juga sampai diterimanya uang perjalanan dinas oleh pegawai. Hal tersebut memiliki beberapa kekurangan seperti resiko terjadinya human error dalam perhitungannya. Perlu adanya digitalisasi dari proses tersebut mengingat resiko human error pada pemrosesan secara manual yang cenderung lebih besar daripada secara digital.
Dalam Kerja Praktek ini, penulis membahas perancangan aplikasi Perjalanan Dinas Online di Yayasan Pendidikan Telkom. Dengan perancangan yang baik, implementasi yang sesuai, serta pengujian yang tepat, maka aplikasi perjalanan dinas berbasis website ini diharapkan dapat memberikan dampak yang positif untuk memberikan inovasi baru di Yayasan Pendidikan Telkom. Hal ini menjadi lebih maksimal karena penulis memakai tools yang sesuai dan mendukung. Seperti CodeIgniter, VS Code, PHPMyadmin, dan XAMPP.