bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fish Meal Replacement by Mixed Plant Protein in the Diets for Juvenile Yellow Catfish Pelteobagrus fulvidraco: Effects on Growth Performance and Health Status
Authors: Han Ya-Kang , Xu Yi-Chuang , Luo Zhi , Zhao Tao , Zheng Hua , Tan Xiao-Ying 
Published: November 2022

Increasing dietary replacement levels of fish meal by alternative plant proteins are of value for aquaculture. Here, a 10-week feeding experiment was undertaken to explore the effects of fish meal replacement by mixed plant protein (at a 2 : 3 ratio of cottonseed meal to rapeseed meal) on growth performance, oxidative and inflammatory responses, and mTOR pathway of yellow catfish Pelteobagrus fulvidraco. Yellow catfish (

2.38
±
0.1

g

,

mean
±
SEM

) were randomly divided into 15 indoors fiberglass tanks, 30 fish each tank, and fed five isonitrogenous (44% crude protein) and isolipidic (9% crude fat) diets with fish meal replaced by mixed plant protein at 0% (the control), 10% (RM10), 20% (RM20), 30% (RM30), and 40% (RM40), respectively. Among five groups, fish fed the control, and RM10 diets tended to have higher growth performance, higher protein content, and lower lipid content in livers. Dietary mixed plant protein substitute increased hepatic free gossypol content and damaged liver histology and reduced the serum total essential amino acids, total nonessential amino acids, and total amino acid contents. Yellow catfish fed the control, and RM10 diets tended to have higher antioxidant capacity. Dietary mixed plant protein replacement tended to promote proinflammatory responses and inhibited mTOR pathway. Based on the second regression analysis of SGR against mixed plant protein substitutes, the optimal replacement level of fish meal by mixed plant protein was 8.7%.
T-Cell Receptor Repertoire Sequencing in the Era of Cancer Immunotherapy
Authors: Frank Meredith L. , Lu Kaylene , Erdogan Can , Han Yi , Hu Jian , Wang Tao , Heymach John V. , Zhang Jianjun , Reuben Alexandre 
Published: November 2022

AbstractT cells are integral components of the adaptive immune system, and their responses are mediated by unique T-cell receptors (TCR) that recognize specific antigens from a variety of biological contexts. As a result, analyzing the T-cell repertoire offers a better understanding of immune responses and of diseases like cancer. Next-generation sequencing technologies have greatly enabled the high-throughput analysis of the TCR repertoire. On the basis of our extensive experience in the field from the past decade, we provide an overview of TCR sequencing, from the initial library preparation steps to sequencing and analysis methods and finally to functional validation techniques. With regards to data analysis, we detail important TCR repertoire metrics and present several computational tools for predicting antigen specificity. Finally, we highlight important applications of TCR sequencing and repertoire analysis to understanding tumor biology and developing cancer immunotherapies.
Anti-BCMA/CD19 CAR T Cells with Early Immunomodulatory Maintenance for Multiple Myeloma Responding to Initial or Later-Line Therapy
Authors: Garfall Alfred L. , Cohen Adam D. , Susanibar-Adaniya Sandra P. , Hwang Wei-Ting , Vogl Dan T. , Waxman Adam J. , Lacey Simon F. , Gonzalez Vanessa E. , Fraietta Joseph A. , Gupta Minnal , Kulikovskaya Irina , Tian Lifeng , Chen Fang , Koterba Natalka , Bartoszek Robert L. , Patchin Margaret , Xu Rong , Plesa Gabriela , Siegel Don L. , Brennan Andrea , Nelson Anne Marie , Ferthio Regina , Cosey Angela , Shea Kim-Marie , Leskowitz Rachel , Four Megan , Wilson Wesley V. , Miao Fei , Lancaster Eric , Carreno Beatriz M. , Linette Gerald P. , Hexner Elizabeth O. , Young Regina M. , Bu Dexiu , Mansfield Keith G. , Brogdon Jennifer L. , June Carl H. , Milone Michael C. , Stadtmauer Edward A. 
Published: November 2022

AbstractWe conducted a phase I clinical trial of anti-BCMA chimeric antigen receptor T cells (CART-BCMA) with or without anti-CD19 CAR T cells (huCART19) in multiple myeloma (MM) patients responding to third- or later-line therapy (phase A, N = 10) or high-risk patients responding to first-line therapy (phase B, N = 20), followed by early lenalidomide or pomalidomide maintenance. We observed no high-grade cytokine release syndrome (CRS) and only one instance of low-grade neurologic toxicity. Among 15 subjects with measurable disease, 10 exhibited partial response (PR) or better; among 26 subjects responding to prior therapy, 9 improved their response category and 4 converted to minimal residual disease (MRD)–negative complete response/stringent complete response. Early maintenance therapy was safe, feasible, and coincided in some patients with CAR T-cell reexpansion and late-onset, durable clinical response. Outcomes with CART-BCMA + huCART19 were similar to CART-BCMA alone. Collectively, our results demonstrate favorable safety, pharmacokinetics, and antimyeloma activity of dual-target CAR T-cell therapy in early lines of MM treatment.Significance:CAR T cells in early lines of MM therapy could be safer and more effective than in the advanced setting, where prior studies have focused. We evaluated the safety, pharmacokinetics, and efficacy of CAR T cells in patients with low disease burden, responding to current therapy, combined with standard maintenance therapy.This article is highlighted in the In This Issue feature, p. 101
AOC: Assembling overlapping communities
Authors: Jakatdar Akhil , Liu Baqiao , Warnow Tandy , Chacko George 
Published: November 2022

AbstractThrough discovery of mesoscale structures, community detection methods contribute to the understanding of complex networks. Many community finding methods, however, rely on disjoint clustering techniques, in which node membership is restricted to one community or cluster. This strict requirement limits the ability to inclusively describe communities because some nodes may reasonably be assigned to multiple communities. We have previously reported Iterative K-core Clustering, a scalable and modular pipeline that discovers disjoint research communities from the scientific literature. We now present Assembling Overlapping Clusters (AOC), a complementary metamethod for overlapping communities, as an option that addresses the disjoint clustering problem. We present findings from the use of AOC on a network of over 13 million nodes that captures recent research in the very rapidly growing field of extracellular vesicles in biology.
Rule of Law Without International Courts
Authors: Bigge David 
Published: November 2022

Abstract
In commenting on the roles of Elihu Root and James Brown Scott in the founding of the Permanent Court of International Justice (PCIJ), former International Court of Justice (ICJ) President Abdulqawi Yusuf stated “there can be no [international] rule of law without a court to apply it.” The American Society of International Law (ASIL)’s International Courts and Tribunals Interest Group recently hosted a symposium event to probe this statement. Without rehashing the voluminous scholarship on the international rule of law, this introduction to the symposium will explore specifically whether a court such as the ICJ or the PCIJ is a prerequisite to an international rule of law. The international court system as currently formulated plainly does not meet the requirements for the rule of law as often defined for domestic systems. Unless we are prepared to accept that there is no international rule of law, or only a partial or developing rule of law, this means that there must be an alternative definition of “rule of law” for international relations, which does not consider international courts as a prerequisite to rule of law in all circumstances, and highlights other enforcement mechanisms and arbitration. Accepting this point does not diminish the important role of international courts in the application of international law but does serve to emphasize how other mechanisms fill important rule-of-law gaps left by international courts. Each of the articles that follow this introduction addresses these mechanisms – including administrative bodies, sanctions, investigative mechanisms, and ad hoc arbitration – and how each mechanism interacts with the international court system.
Homeplace: Black Teachers Creating Space for Black Students in Mathematics Classrooms
Authors: Vaidya Anjanette N. , Battey Dan 
Published: November 2022

Background: Although large-scale research over the last 15 years demonstrates the positive effects of Black teachers for Black students on various student outcomes, these studies focus on average effects. This leaves space to examine classroom practices to detail how the positive effects may be realized through the everyday interactions between Black teachers and their Black students, specifically in mathematics. To conceptualize the mathematics classroom we draw on hooks’s (2001) concept of “Homeplace” as a site where one is humanized in resistance to broader contexts of power, as a “haven” free from negative dominant discourses. Focus of Study: This research documents the classroom practices of successful Black mathematics teachers who are affirming students’ identities through their classroom practices: How do successful Black mathematics teachers enact affirming mathematics classrooms with their Black students? Setting: This research was a secondary analysis of videos collected as part of the Gates-funded Understanding Teaching Quality (UTQ) project. All of the schools in the UTQ study were located in one metropolitan area. Case Study Selection: The study used MANOVA to quantitatively select teachers based on mathematics achievement and quality of relational interactions. Two teachers were selected and, although not part of the selection criteria, both mathematics teachers identified as Black. Research Design: The study used a case study design to describe the mathematics practices of two Black teachers. Data Collection and Analysis: The dataset included four lessons per teacher with two cameras for each lesson. Open coding was used to identify the practices used by teachers drawing on Homeplace as an orienting concept. Findings: The classrooms enacted Homeplace through affirming students’ humanity and communicating a sense of belonging in three ways: building collective responsibility for the mathematics, framing students as mathematically capable, and relating to students’ lives. In addition to the themes, undercurrents of care, humor, praise, and the use of Black Language were clearly visible. Conclusions: Although the classrooms did not display the sociopolitical consciousness foundational to culturally relevant pedagogy, the Black teachers did create an environment consistent with Homeplace. Through cultivating a classroom that affirmed Black students’ humanity and dignity and communicated to them a sense of belonging, they resisted negative racialized narratives and increased students’ mathematics achievement.
Biomechanical Effect of Differential Tensioning on Suture-Augmented Ulnar Collateral Ligament Reconstruction of the Elbow
Authors: Iannucci Leanne E. , Koscso Jonathan M. , Castile Ryan M. , Lake Spencer P. , Smith Matthew V. 
Published: November 2022

Background: Medial ulnar collateral ligament (mUCL) reconstructions are becoming increasingly prevalent among the overhand throwing population. Suture tape augmentation has the potential to provide biomechanical advantages over standard docking reconstruction. However, the optimal tensioning of the suture augmentation technique has not yet been evaluated. Purpose: To compare the subfailure biomechanical performance and graft strain of a standard docking mUCL reconstruction to an mUCL reconstruction using suture tape augmentation tensioned with 1 mm or 3 mm of laxity. Study Design: Controlled laboratory study. Methods: A total of 18 cadaveric elbows were dissected to the mUCL anterior band and biomechanically assessed via a valgus torque protocol to failure. Elbows were randomly assigned to be reconstructed via (1) a standard docking technique, (2) a suture-augmented reconstruction with 1-mm laxity, or (3) a suture-augmented reconstruction with 3-mm laxity. Reconstructed elbows were then subjected to the same loading protocol. Subfailure mechanical properties, failure mode, and mUCL/palmaris strain were assessed. Results: All reconstruction groups had decreased rotational stiffness, torque at 5° of angular rotation, and resilience compared with matched native controls. There were no differences in transition torque between groups. The failure mode of suture-augmented specimens was most often due to bone tunnel failure or reaching the maximum allowable angular displacement. In native controls or docking reconstructions, the primary failure mechanism was in the ligament or graft midsubstance. There were no significant differences in strain on the reconstructed or suture-augmented groups at any laxity compared with native controls. Conclusion: Suture augmentation results in similar subfailure joint biomechanical properties as the standard docking reconstruction procedure at both laxity levels in a cadaveric model. There are improvements in the failure mode of suture-augmented specimens compared with standard docking. Graft strain may be modestly reduced in the 1-mm laxity group compared with other reconstruction groups. Clinical Relevance: Suture augmentation at both 1-mm and 3-mm laxity appears to offer similar advantages in subfailure biomechanics to standard docking reconstruction of the mUCL, with some improvements associated with failure mode. Strain data suggest a potential avoidance of graft stress shielding when tensioning the suture augmentation to 3-mm laxity, which is not as apparent with 1-mm laxity.
Association of Elevated Posterior Tibial Slope With Revision Anterior Cruciate Ligament Graft Failure in a Matched Cohort Analysis
Authors: Duerr Robert A. , Ormseth Benjamin , DiBartola Alex , Geers Katie , Kaeding Christopher C. , Siston Robert , Flanigan David C. , Magnussen Robert A. 
Published: November 2022

Background: Elevated posterior tibial slope (PTS) has been identified as an important risk factor in anterior cruciate ligament (ACL) injuries and ACL graft failures. The cutoff value to recommend treatment with slope-reducing osteotomy remains unclear and is based on expert opinion and small case series. Purpose: (1) To determine whether there is a difference in PTS shown on lateral knee radiographs and magnetic resonance imaging (MRI) scans in a group of patients who experienced revision ACL graft failure versus a control group of patients who underwent successful revision ACL reconstruction, (2) to identify cutoff values of PTS measurements that predict risk of revision ACL graft failure, and (3) to examine whether there is a correlation between radiographic and MRI measurements of PTS. Study Design: Case-control study; Level of evidence, 3. Methods: A total of 38 patients who experienced revision ACL graft failure were identified from a revision ACL database. These patients were matched 1:1 by age, sex, and graft type to a group of 38 control patients who underwent revision ACL reconstruction with no evidence of graft failure at a minimum 2 years of follow-up. Medial and lateral PTS were measured by lateral knee radiographs and MRI scans of the affected limb. Demographics, surgical characteristics, and PTS were compared between the groups. The optimal cutoff values of medial and lateral PTS per radiographs and MRI scans for predicting increased risk of revision ACL graft failure were determined by receiver operating characteristic curves. Conditional multivariable logistic regression was used to assess the relative contribution of PTS cutoff values as a predictor of revision graft failure. Results: The mean PTS values in the failure group were significantly higher than those in the control group on radiographs (medial, 13.2°± 2.9° vs 10.3°± 2.9°; P < .001; lateral, 12.9°± 3.0° vs 9.8°± 2.8°; P < .001) and MRI scans (medial, 7.2°± 3.1° vs 4.8°± 2.9°; P < .001; lateral, 8.4 ± 3.1° vs 5.9 ± 3.0°; P < .001). A radiographic medial PTS ≥14° had the highest increased risk of revision ACL graft failure with sensitivity equal to 50% and specificity to 92.1% (odds ratio, 18.71; 95% CI, 2.0-174.9; P = .01). Conclusion: Elevated PTS was a significant risk factor for revision ACL graft failure. Patients with radiographic medial PTS ≥14° had 18.7-times increased risk of revision ACL failure.
Characterizing the Influence of Television Health Entertainment Narratives in Lay Populations: A Scoping Review
Authors: Hoffman Beth L , Hoffman Robert , VonVille Helena M , Sidani Jaime E , Manganello Jennifer A , Chu Kar-Hai , Felter Elizabeth M , Miller Elizabeth , Burke Jessica G 
Published: November 2022

Objective To conduct a scoping review of published literature examining the influence of health storylines from fictional television programs on viewers. Data Source We performed literature searches in Medline, PsycINFO, and Mass Media Complete in October 2021, and examined bibliographies of included articles and conducted forward searching using Web of Science with included articles. Study Inclusion and Exclusion Criteria Selected studies were required to be original research published in English, involve exposure to fictional television programming by individuals not in the medical field, and assess associations between exposure and health-related outcomes. Data Extraction Article screening and data abstraction were performed by two independent researchers using DistillerSR (Cohen’s κ range: .73-1.00). Data Synthesis We analyzed and qualitatively described the data using methods of scoping reviews described by PRISMA-ScR. Results Of 5,537 unique records identified, 165 met inclusion criteria. The most frequently studied program was ER (n = 22, 13.3%). Most studies had adult participants (n = 116, 70.3%) and used quantitative methods (n = 136, 82.4%). The most frequently examined health topics were sexual behavior (n = 28, 17.0%) and mental health (n = 28, 17.0%). Exposure had a positive influence on viewers’ health-related outcomes in 28.5% (n = 47) of studies. Conclusion Health storylines on fictional television influence viewers. Future research could address gaps identified in this review to further elucidate the influence of this programming on health promotion and disease prevention.
Confronting the Infodemic and Fake News to End Stigma and Discrimination in HIV/AIDS: Promoting Zero Discrimination Practices in Brazil With Massive Open Online Course
Authors: Canavese Daniel , Polidoro Maurício , Ferreira Ariadne Ribeiro , Velasquez Claudia , Perry Gabriela Trindade 
Published: November 2022

Introduction Overcoming misinformation is essential considering stigma and discrimination in the HIV/AIDS epidemic. This report presents the preliminary results of a health education strategy based on the massive open online course (MOOC) on Zero Discrimination in Brazil. Methods Case study describing the development of the MOOC and its validation using the Delphi technique. Pre- and posttests were administered. People who enrolled from October 2021 to March 2022 were included in the study. Results and discussion MOOC was made available free of charge for mobile phones, tablets, and desktops and included a 90-hr study certificate. Over 6 months, there were n = 665 people enrolled from different regions, mainly from the health field or working in the public health system. The completion rate of people included in the study (26.62%; n = 177) was above the average for other MOOCs. Conclusions Initial results are promising but demand more extensive monitoring.
The general health status of newly arrived asylum seekers in Denmark
Authors: Nissen R. Primdahl , Frederiksen H.W. , Brande S.E. , Norredam M. 
Published: November 2022

Aims: The number of asylum seekers in Europe is increasing and is likely to do so continuously due to conflicts, poverty and climate. Asylum seekers are exposed to many health risk factors related to their migration process and this study aimed to explore their general health status on arrival at an immigration country. Methods: A retrospective study including 1907 general health assessments (GHAs) of adult asylum seekers arriving in Denmark between 1 September 2017 and 31 December 2019 was undertaken. The GHA is offered to all adult asylum seekers as part of the health-care reception programme. Only asylum seekers who attended the GHA within 1 month of their arrival in Denmark were included. Data comprised sociodemographic factors, health outcomes, and indication of exposure to trauma and torture. Data were described by absolute and relative frequencies, means and through regression analyses. Results: The majority of asylum seekers were male (58.6%) of Middle Eastern origin with a mean age of 33.6 years (SD = 12.1). More than half (60.1%) of the participants had one or more physical health complaints, whereas mental health complaints were less frequent (25.0%). Asylum seekers, who had been exposed to trauma were more likely to have physical health complaints (OR 1.52, 95% CI 1.22;1.89) and to have symptoms of mental health problems (OR 12.71, 95% CI 8.76;18.45). These complaints were substantially elevated for survivors of torture. Conclusions: This relatively high prevalence of health complaints, both physical and mental, emphasises the necessity of providing appropriate and timely health care from the very beginning of the asylum process.