bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE IMPACT OF BROILER FARMING BUSINESS PARTNERSHIP ON PRODUCTION COST AND INCOME IN METRO CITY
Authors: Rosanti Novi , Okta Sari Nia , Endaryanto Teguh 
Published: May 2022

Partnership pattern was the pattern of managing broiler chicken business through cooperation with companies that offered many benefits so that most breeders were encouraged to established partnership patterns. But in the implementation of partnerships not always run in accordance with the agreement because there were some frauds committed by farmers and companies. The risk of frauds made some farmers chose to manage the broiler breed chicken business independently. The difference in implementation between partnership patterns and self-sustaining patterns can have a performance impact on broiler chicken breeders. This study aims to analyze the partnership patterns, analyze the partnership's driving factors and analyze the impact of partnerships on the production and income costs of broiler breed chicken farmers in Metro City. This study was conducted from October 12 to November 30, 2020 located in Metro City. The methods were used in this research were qualitative and quantitative combined methods. The data was collected through a survey by interviewing directly 59 respondents. The result of this research were The pattern of partnerships of broiler breed chicken farmers in Metro City was the plasma core pattern, 2) The driving factors of partnership in broiler chicken breeders were capital availability motivation, market guarantee motivation, price guarantee motivation and high income motivation, 3) Statistically the partnership pattern had an impact on income and labor allocation. The company could improve the services that were felt by farmer tobe lacking, such as the accuracy of providing production facillities and payment of harverts and could provide competitive sell prices to breeders partner.
Effects of systemic isotretinoin treatment on retinal nerve fiber layer thickness and corneal endothelial cell density
Authors: UZLU Dilek , BAYKAL SELÇUK Leyla , TURK Adem , OĞUZER Şeyda Ece , OZBAY Ahmet Duhan , YASAR Yasin 
Published: May 2022

Objective To investigate the effects of systemic isotretinoin therapy on retinal nerve fiber layer (RNFL) thickness and corneal endothelial cell density (ECD)
Methods Thirty-three patients completed the study. All patients were given an ophthalmic examination at baseline and after six months of isotretinoin therapy. All patients underwent a detailed eye examination including best corrected visual acuity, intraocular pressure, refractive errors, biomicroscopic anterior segment and fundus examination. In addition, Schirmer test without topical anesthesia, tear break up time, retinal nerve fiber thickness measurements with optical coherence tomography (OCT) and specular microscopy measurements were performed on all patients.
Results There were 23 female (69.7 %) and 10 male (30.3 %) patients. Post treatment RNFL values were
significantly lower than pretreatment values on both right and left eyes (P=0.048 and P
Impact of Rehabilitation Interventions on Walking Endurance in Children with Cerebral Palsy. A Systematic Literature Review
Authors: Kavaliauskaitė Ieva , Petrulytė Jovita , Budrienė Lina , Raistenskis Juozas 
Published: May 2022

Background. Decreased walking endurance in children with CP results in impaired gait function and adversely affects participation. Appropriate rehabilitation interventions can significantly increase walking endurance and associated functional efficiency.
The aim. To evaluate the effectiveness of different rehabilitation interventions for walking endurance of children with CP by analyzing scientific research.
Methods. The selection of articles was performed in the “PubMed” database, according to the keywords and criteria identifying the study topic. The selection scheme was performed according to the PRISMA guidelines.
Results. 15 articles were included in the systematic review. Statistically significantly (p<0,05) higher walking endurance was found after: “Gait Trainer GT1” workout; muscle strength-power training; strength-endurance training + usual interventions (INT) and passive movement intervention, all compared to INT. Also, after: treadmill + INT (vs. walking + INT); treadmill with the “3DCaLT” robotic system (vs. treadmill); virtual reality with treadmill + INT (vs. treadmill + INT); whole-body vibration (vs. placebo).
Conclusions. In children with cerebral palsy, certain gait training, muscle strength training, and passive movement interventions increase walking endurance more effectively compared to non-combined usual interventions. When choosing from several gait training interventions, the effectiveness of walking endurance training depends on the specifics of the intervention. Also, walking endurance is effectively enhanced by whole-body vibration (compared to placebo) and a virtual reality component combined with gait training (compared to the same intervention without a virtual reality component).
Keywords: children, cerebral palsy, walking endurance, rehabilitation, systematic review.
Pendidikan Karakter dalam Membangun Kecerdasan Moral bagi Anak Usia Dini Perspektif Thomas Lickona
Authors: Susanti Salamah Eka 
Published: May 2022

Padadasarnya pendidikan berfungsi membentuk karakter yang baik, karena karakter yang baik merupakan modal awal bagi manusia untuk menjadi yang mampu mewujudkan kehidupan yang sejahtera. Menurut Thomas Lickona seorang pakar pendidikan karakter mengemukakan, bahwa konsep mengenai pendidikan karakter yang sering dipakai sebagai rujukannya yaitu diawali dengan knowing, filling, dan action. Nilai- nilai karakter yang digagas oleh Thomas Lickona diantaranya yaitu : Pertama, dengan kejujuran. Kedua, dengan adil. Ketiga, dengan tanggung jawab. Keempat, dengan berani. Kelima, dengan mau bekerja. Keenam, dengan disiplin. Selain itu Thomas Lickona juga mengemukakan, ada lima pendekatan dalam pendidikan karakter, yaitu sebagai berikut : (1). Pendekatan penanaman nilai (inculcation approach) , (2). Pendekatan perkembangan moral kognitif (cognitive moral development approach, (3). Pendekatan analisis nilai (values analysis approach), (4) pendekatan klarifikasi nilai (values clarification approach), (5). Pendekatan pembelajaran berbuat (action learning approach).
Pyroptosis-Related Signature and Tumor Microenvironment Infiltration Characterization in Head and Neck Squamous Cell Carcinoma
Authors: Wu Zeng-Hong , Wu Bian , Li Cheng , Zhang You-Jing , Zhou Tao 
Published: May 2022

Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most widespread and deadly cancer. Until now, very few studies have systematically evaluated the role of pyroptosis-related genes (PRGs) and lncRNAs in HNSCC patients.Methods: We integrated the genomic data to comprehensively assess the role of pyroptosis with the tumor microenvironment cell-infiltrating characteristics in HNSCC. In addition, we also constructed a set of the scoring system to calculate the pyroptosis dysfunction in each patient.Results: The analysis of the CNV alteration frequency displayed that CNV changes were common in 33 PRGs, and the frequency of copy number gain and loss was similar. CASP8 demonstrated the highest mutation frequency. Considering the individual heterogeneity, a scoring system to quantify the pyroptosis pattern in each patient was constructed based on these phenotypic-related genes, which we named as the PyroptosisScore. The results indicated that the low PyroptosisScore group experienced increased extensive TMB than the high group, with the most significant mutated genes being TP53 and TTN. Finally, we tried to find some useful pyroptosis-related lncRNAs, and 14 differentially expressed lncRNAs were selected as independent prognosis factors of HNSCC patients based on the multivariate Cox analysis.Conclusion: This work suggests the pyroptosis features and the potential mechanisms of the tumor microenvironment. The exploration may assist in identifying novel biomarkers and help patients predict prognosis, clinical diagnosis, and management.
Inter-ankle Systolic Blood Pressure Difference Is a Marker of Increased Fasting Blood-Glucose in Asian Pregnant Women
Authors: Zhang Ruo , Viswambharan Hema , Cheng Chew Weng , Garstka Malgorzata Anna , Kain Kirti 
Published: May 2022

ObjectiveThis cross-sectional study aimed to determine the relationship between clinical blood pressures and blood pressures measured using Doppler with blood glucose in pregnancy by ethnicity.MethodsWe recruited 179 (52% White European, 48% Asian) pregnant women at 24-28 weeks of gestation who underwent a glucose tolerance test in an antenatal clinic in Bradford Royal Infirmary, the UK, from 2012 to 2013. Systolic blood pressures in the arm (left and right brachial) and ankle [left and right posterior tibial (PT) and dorsalis pedalis (DP)] blood pressures were measured using a Doppler probe. The inter-arm (brachial) and inter-ankle (PT and DP) systolic blood pressure differences were obtained. A multivariate linear regression model adjusted for age, body mass index, and diabetes risk was used to assess the relationship between blood pressures and blood glucose.ResultsAsian pregnant women had higher blood glucose but lower ankle blood pressures than White Europeans. In White Europeans, brachial blood pressures and clinical blood pressures were positively associated with fasting blood glucose (FBG), but brachial blood pressures did not perform better as an indicator of FBG than clinical blood pressures. In Asians, increased inter-ankle blood pressure difference was associated with increased FBG. For each 10 mmHg increase in the inter-ankle blood pressure difference, FBG increased by 0.12 mmol/L (Beta=0.12, 95%CI: 0.01-0.23).ConclusionThe relationship between blood pressures with blood glucose differed by ethnicity. In Asians, inter-ankle systolic blood pressure difference was positively associated with blood glucose. This is first ever report on ankle blood pressures with blood glucose in pregnancy which suggests future potential as a non-invasive gestational diabetes risk screening tool.
Vitamin D Supplementation Improves Mitochondrial Function and Reduces Inflammation in Placentae of Obese Women
Authors: Phillips Elysse A. , Hendricks Nora , Bucher Matthew , Maloyan Alina 
Published: May 2022

BackgroundAbout 30% of women entering pregnancy in the US are obese. We have previously reported mitochondrial dysregulation and increased inflammation in the placentae of obese women. Vitamin D (VitD) is a major player in calcium uptake and was shown to modulate mitochondrial respiration and the immune/inflammation system. Studies show decreased VitD levels in obese individuals; however, the effect of maternal obesity on VitD metabolism and its association with placental function remains understudied.MethodsMaternal and cord blood plasma and placental samples were collected upon C-section from normal-weight (NW, body mass index [BMI]&lt;25) and obese (OB, BMI&gt;30) women with uncomplicated pregnancies at term. We measured 25(OH)D3 (calcidiol) levels in maternal and cord blood plasma using ELISA. We assessed the expression of CYP27B1, an activator of calcidiol, and Vitamin D receptor (VDR) in placentae from NW and OB, and women with gestational diabetes and preeclampsia. In addition, we examined the effects of VitD supplementation on mitochondrial function and inflammation in trophoblasts from NW and OB, using the Seahorse Bioanalyzer and Western blot, respectively.ResultsVitamin D levels in blood from OB but not NW women and in cord blood from babies born to NW and OB women showed a significant inverse correlation with maternal pre-pregnancy BMI (r=-0.50, p&lt;0.1 and r=-0.55, p=0.004 respectively). Cord plasma VitD levels showed a positive correlation with placental efficiency, i.e., the ratio between fetal and placental weight, as well as with maternal blood VitD levels (r=0.69 and 0.83 respectively, p&lt;0.00). While we found no changes in CYP27B1 in OB vs. NW women, VDR expression were decreased by 50% (p&lt;0.03) independent of fetal sex. No changes in VDR expression relative to BMI-matched controls were observed in the placentae of women with gestational diabetes or preeclampsia. Cytotrophoblasts isolated from placentae of OB women showed a dose-dependent increase in VDR expression after 24-hour treatment with calcitriol (10 nM and 100 nM), an active form of VitD. Trophoblasts isolated from OB women and treated with calcitriol improved mitochondrial respiration (p&lt;0.05). We also found a two-fold increase in expression of the NLRP3 inflammasome and the pro-inflammatory cytokine IL-18 in trophoblasts isolated from placentae of OB women (p&lt;0.05), with IL-18 expression being reversed by calcitriol treatment (100 nM).ConclusionsWe show that VitD deficiency is at least partially responsible for mitochondrial dysfunction and increased inflammation in the placentae of obese women. Vitamin D supplementation could be beneficial in improving placental dysfunction seen in obese women.
Case Report: Phenotype-Driven Diagnosis of Atypical Dravet-Like Syndrome Caused by a Novel Splicing Variant in the SCN2A Gene
Authors: Sharkov Artem , Sparber Peter , Stepanova Anna , Pyankov Denis , Korostelev Sergei , Skoblov Mikhail 
Published: May 2022

Febrile-associated epileptic encephalopathy is a large genetically heterogeneous group that is associated with pathogenic variants in SCN1A, PCDH19, SCN2A, SCN8A, and other genes. The disease onset ranges from neonatal or early-onset epileptic encephalopathy to late-onset epilepsy after 18 months. Some etiology-specific epileptic encephalopathies have target therapy which can serve as a clue for the correct genetic diagnosis. We present genetic, clinical, electroencephalographic, and behavioral features of a 4-year-old girl with epileptic encephalopathy related to a de novo intronic variant in the SCN2A gene. Initial NGS analysis revealed a frameshift variant in the KDM6A gene and a previously reported missense variant in SCN1A. Due to lack of typical clinical signs of Kabuki syndrome, we performed X-chromosome inactivation that revealed nearly complete skewed inactivation. Segregation analysis showed that the SCN1A variant was inherited from a healthy father. The proband had resistance to multiple antiseizure medications but responded well to sodium channel inhibitor Carbamazepine. Reanalysis of NGS data by a neurogeneticist revealed a previously uncharacterized heterozygous variant c.1035–7A&gt;G in the SCN2A gene. Minigene assay showed that the c.1035–7A&gt;G variant activates a cryptic intronic acceptor site which leads to 6-nucleotide extension of exon 9 (NP_066287.2:p.(Gly345_Gln346insTyrSer). SCN2A encephalopathy is a recognizable severe phenotype. Its electro-clinical and treatment response features can serve as a hallmark. In such a patient, reanalysis of genetic data is strongly recommended in case of negative or conflicting results of DNA analysis.
A Ubiquitin-Proteasome Gene Signature for Predicting Prognosis in Patients With Lung Adenocarcinoma
Authors: Tang Yunliang , Guo Yinhong 
Published: May 2022

Background: Dysregulation of the ubiquitin-proteasome system (UPS) can lead to instability in the cell cycle and may act as a crucial factor in both tumorigenesis and tumor progression. However, there is no established prognostic signature based on UPS genes (UPSGs) for lung adenocarcinoma (LUAD) despite their value in other cancers.Methods: We retrospectively evaluated a total of 703 LUAD patients through multivariate Cox and Lasso regression analyses from two datasets, the Cancer Genome Atlas (n = 477) and GSE31210 (n = 226). An independent dataset (GSE50081) containing 128 LUAD samples were used for validation.Results: An eight-UPSG signature, including ARIH2, FBXO9, KRT8, MYLIP, PSMD2, RNF180, TRIM28, and UBE2V2, was established. Kaplan-Meier survival analysis and time-receiver operating characteristic curves for the training and validation datasets revealed that this risk signature presented with good performance in predicting overall and relapsed-free survival. Based on the signature and its associated clinical features, a nomogram and corresponding web-based calculator for predicting survival were established. Calibration plot and decision curve analyses showed that this model was clinically useful for both the training and validation datasets. Finally, a web-based calculator (https://ostool.shinyapps.io/lungcancer) was built to facilitate convenient clinical application of the signature.Conclusion: An UPSG based model was developed and validated in this study, which may be useful as a novel prognostic predictor for LUAD.
Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies
Authors: Foo Valencia Hui Xian , Mehta Jodhbir , Chan Anita Sook Yee , Ong Hon Shing 
Published: May 2022

PurposeTo describe a case series of peripheral ulcerative keratitis (PUK) as a paraneoplastic condition in three patients with known underlying systemic solid tumor malignancies.ObservationsThree patients with different systemic malignancies (1 recurrent breast cancer, 1 metastatic thyroid cancer, and 1 metastatic gastric adenocarcinoma) were identified to have PUK with significant corneal stromal melt. Autoimmune and infective work up for other etiologies were all negative. They all responded well to topical steroids and intravenous methylprednisolone. One patient had recurrences of her PUK and required repeated amniotic grafts and tectonic keratoplasties before her corneal condition stabilized.Conclusions and ImportancePUK can be a rare manifestation of systemic solid tumor malignancies. Although PUK may not be an indicator of progression of the underlying malignancy, it can be sight-threatening. This case series highlights the necessity for clinicians to refer patients with systemic malignancies presenting with inflamed eyes for an early ophthalmological review. This facilitates the detection of this blinding disease, allowing for early therapeutic interventions and potentially better visual outcomes for these patients.
Early-Life Exposure to Malnutrition From the Chinese Famine on Risk of Asthma and Chronic Obstructive Pulmonary Disease in Adulthood
Authors: Jin Changbo , Zhang Tiantian , Li Yongzhen , Shi Wenming 
Published: May 2022

ObjectivesIntrauterine malnutrition has a long-term effect on respiratory and lung function. However, few studies have explored the association between early-life exposure to famine with asthma and chronic obstructive pulmonary disease (COPD) in adulthood. Therefore, we aimed to investigate the association of early-life exposure to the Chinese famine of 1959–1962 with asthma and COPD later in life.MethodsThis national population-based study included 6,771 participants from the baseline survey of the China Health and Retirement Longitudinal Study (CHARLS) who were born around the time of the Chinese famine. The famine exposure groups were determined according to the participants' birth year as non-exposed (1964–1967), fetal-exposed (1959–1962), preschool-exposed (1954–1957), and school-age exposed (1950–1953). Information about the demographic characteristics, self-reported doctor-diagnosed asthma and COPD, behavior and lifestyles, and indoor pollution were collected using validated questionnaires. In addition, peak expiratory flow (PEF) was measured to assess pulmonary function. Multivariable logistic regression and generalized linear mixed models were performed to explore the risk of adult asthma and COPD, PEF changes during various famine exposure periods compared with the non-exposed group. Stratified and sensitivity analyses were conducted to examine the modification and robustness of the association.ResultsThe prevalence of doctor-diagnosed asthma and COPD was 2.8 and 8.1%, respectively. Compared with the non-exposed group, the risk was significantly higher in the fetal-exposed group for asthma [adjusted odds ratio, (aOR) = 1.87, 95% confidence interval (CI):1.14–3.07] and the school-age exposed group [1.30 (1.00–1.69)] for COPD after controlling for confounders. Furthermore, we observed that fetal exposure to famine was significantly associated with a decrement of PEF in adulthood [β = −11.38 (−22.75 to −0.02)] compared with the non-exposed group. Stratified analyses showed that the association of asthma was stronger in men, who resided in severely famine-affected areas, smoked, and used solid fuels for cooking. No clearly consistent association was observed for subsequent COPD.ConclusionsOur results suggest that fetal exposure to the Chinese famine is significantly associated with the increased risk of asthma in adulthood. Future prospective studies are warranted to examine the association and mechanisms.
Dietary Fiber Intake Is Related to Skeletal Muscle Mass, Body Fat Mass, and Muscle-to-Fat Ratio Among People With Type 2 Diabetes: A Cross-Sectional Study
Authors: Takahashi Fuyuko , Hashimoto Yoshitaka , Kaji Ayumi , Sakai Ryosuke , Kawate Yuka , Okamura Takuro , Okada Hiroshi , Kitagawa Noriyuki , Nakanishi Naoko , Majima Saori , Osaka Takafumi , Senmaru Takafumi , Ushigome Emi , Asano Mai , Hamaguchi Masahide , Yamazaki Masahiro , Fukui Michiaki 
Published: May 2022

ObjectivesTo investigate the relationship between dietary fiber intake and skeletal muscle mass, body fat mass, and muscle-to-fat ratio (MFR) among men and women with type 2 diabetes (T2D).MethodsThis cross-sectional study involved 260 men and 200 women with T2D. Percent skeletal muscle mass (%) or percent body fat mass (%) was calculated as (appendicular muscle mass [kg] or body fat mass [kg]/body weight [kg]) × 100. MFR was calculated as appendicular muscle mass divided by body fat mass. Information about dietary fiber intake (g/day) was obtained from a brief-type self-administered diet history questionnaire.ResultsDietary fiber intake was correlated with percent body fat mass (r = –0.163, p = 0.021), percent skeletal muscle mass (r = 0.176, p = 0.013), and MFR (r = 0.157, p = 0.026) in women. However, dietary fiber intake was not correlated with percent body fat mass (r = –0.100, p = 0.108), percent skeletal muscle mass (r = 0.055, p = 0.376), and MFR (r = 0.065, p = 0.295) in men. After adjusting for covariates, dietary fiber intake was correlated with percent body fat mass (β = 0.229, p = 0.009), percent skeletal muscle mass (β = 0.364, p &lt; 0.001), and MFR (β = 0.245, p = 0.006) in women. Further, dietary fiber intake was related to percent skeletal muscle mass (β = 0.221, p = 0.008) and tended to be correlated with percent body fat mass (β = 0.148, p = 0.071) in men.ConclusionDietary fiber intake was correlated with skeletal muscle mass, body fat mass, and MFR among women with T2D.