bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive analysis of the expression and significance of CXCLs in human diffuse large B-cell lymphoma
Authors: Zhou Xiaonan , Guo Shizhu , Shi Yonghong 
Published: February 2022

AbstractCXCL chemokines (CXCLs) are small cytokines or signal proteins secreted by cells that have been proven to be linked to the occurrence and development of many kinds of cancer. However, the expression and diagnostic and prognostic value of CXCLs in diffuse large B-cell lymphoma (DLBCL) remain to be further studied. We obtained CXCL transcription and survival data of patients with DLBCL from Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), The Cancer Genome Atlas (TCGA), TIMER and cBioPortal databases. R software, STRING and EXCEL were used to process the data. This study discovered that the expression levels of CXCL9-14 in DLBCL were higher than those in normal tissues, while CXCL4, CXCL7 and CXCL8 were lower in tumor than in normal tissues. The expression levels of CXCL2, CXCL10 and CXCL11 were related to tumor stage. CXCL9-14 could be used as an auxiliary molecular marker for the diagnosis of DLBCL. CXCL17 might be a potential prognostic marker of DLBCL.
Ether anesthetics prevents touch-induced trigger hair calcium-electrical signals excite the Venus flytrap
Authors: Scherzer Sönke , Huang Shouguang , Iosip Anda , Kreuzer Ines , Yokawa Ken , AL-Rasheid Khaled A. S. , Heckmann Manfred , Hedrich Rainer 
Published: February 2022

AbstractPlants do not have neurons but operate transmembrane ion channels and can get electrical excited by physical and chemical clues. Among them the Venus flytrap is characterized by its peculiar hapto-electric signaling. When insects collide with trigger hairs emerging the trap inner surface, the mechanical stimulus within the mechanosensory organ is translated into a calcium signal and an action potential (AP). Here we asked how the Ca2+ wave and AP is initiated in the trigger hair and how it is feed into systemic trap calcium-electrical networks. When Dionaea muscipula trigger hairs matures and develop hapto-electric excitability the mechanosensitive anion channel DmMSL10/FLYC1 and voltage dependent SKOR type Shaker K+ channel are expressed in the sheering stress sensitive podium. The podium of the trigger hair is interface to the flytrap’s prey capture and processing networks. In the excitable state touch stimulation of the trigger hair evokes a rise in the podium Ca2+ first and before the calcium signal together with an action potential travel all over the trap surface. In search for podium ion channels and pumps mediating touch induced Ca2+ transients, we, in mature trigger hairs firing fast Ca2+ signals and APs, found OSCA1.7 and GLR3.6 type Ca2+ channels and ACA2/10 Ca2+ pumps specifically expressed in the podium. Like trigger hair stimulation, glutamate application to the trap directly evoked a propagating Ca2+ and electrical event. Given that anesthetics affect K+ channels and glutamate receptors in the animal system we exposed flytraps to an ether atmosphere. As result propagation of touch and glutamate induced Ca2+ and AP long-distance signaling got suppressed, while the trap completely recovered excitability when ether was replaced by fresh air. In line with ether targeting a calcium channel addressing a Ca2+ activated anion channel the AP amplitude declined before the electrical signal ceased completely. Ether in the mechanosensory organ did neither prevent the touch induction of a calcium signal nor this post stimulus decay. This finding indicates that ether prevents the touch activated, glr3.6 expressing base of the trigger hair to excite the capture organ.
Biomimetic hierarchical implant surfaces promote early osseointegration in osteoporotic rats by suppressing macrophage activation and osteoclastogenesis
Authors: Dai Xiaohan , Bai Yunyang , Heng Boon Chin , Li Yiping , Tang Zhangui , Lin Changjian , Liu Ousheng , He Ying , Zhang Xuehui , Deng Xuliang 
Published: February 2022

On biomimetic hierarchical titanium surfaces, macrophages exhibited more M2 versus M1 polarization, thereby improving osseointegration under osteoporotic conditions by creating a favourable osteo-immunomodulatory microenvironment.
eROSITA study of the globular cluster 47 Tucanae
Authors: Saeedi Sara , Liu Teng , Knies Jonathan , Sasaki Manami , Becker Werner , Bulbul Esra , Dennerl Konrad , Freyberg Michael , Laktionov Roman , Merloni Andrea 
Published: February 2022

Aims. We present the results of the analysis of five observations of the globular clutser 47 Tucanae (47 Tuc) with the extended Roentgen Survey with an Imaging Telescope Array (eROSITA) on board the Spektrum-Roentgen-Gamma (Spektr-RG, SRG). We study the X-ray population in the field of one of the most massive globular clusters in our Milky Way. We focused on the classification of point-like sources in the field of 47 Tuc. The unresolved dense core of 47 Tuc (1.7 radius) and also sources that show extended emission are excluded from this study.
Methods. We applied different methods of X-ray spectral and timing analysis together with multi-wavelength studies to classify the X-rays sources in the field of 47 Tuc.
Results. We detected 888 point-like sources in the energy range of 0.2–5.0 keV. We identified 126 background active galactic nuclei and 25 foreground stars. One of the foreground stars is classified as a variable M dwarf. We also classified 14 X-ray sources as members of 47 Tuc, including one symbiotic star, two quiescent low-mass X-ray binaries, and four cataclysmic variables. There are also five X-ray sources that can either be a cataclysmic variable or a contact binary, and also one X-ray source can be an active binary (type RS CVn). We identified one X-ray binary that belongs to the Small Magellanic Cloud. Moreover, we calculated the X-ray luminosity function of 47 Tuc. No significant population that seems to belong to the globular cluster is observed in the energy range of 0.5–2.0 keV using eROSITA observations.
Recycling of the first atmospheres of embedded planets: Dependence on core mass and optical depth
Authors: Moldenhauer T. W. , Kuiper R. , Kley W. , Ormel C. W. 
Published: February 2022

Context. Recent observations found close-in planets with significant atmospheres of hydrogen and helium in great abundance. These are the so-called super-Earths and mini-Neptunes. Their atmospheric composition suggests that they formed early during the gas-rich phase of the circumstellar disk and were able to avoid becoming hot Jupiters. As a possible explanation, recent studies explored the recycling hypothesis and showed that atmosphere-disk recycling is able to fully compensate for radiative cooling and thereby halt Kelvin-Helmholtz contraction to prevent runaway gas accretion.
Aims. To understand the parameters that determine the efficiency of atmospheric recycling, we extend our earlier studies by exploring the effects of the core mass, the effect of circumstellar gas on sub-Keplerian orbits (headwind), and the optical depth of the surrounding gas on the recycling timescale. Additionally, we analyze their effects on the size and mass of the forming atmosphere.
Methods. We used three-dimensional (3D) radiation-hydrodynamic simulations to model a local shearing box centered on the planet. Our planet is located at a separation of ap = 0.1 au from its solar-type host star, and we scanned the core mass range from 1 to 10 MEarth. In order to measure and track the recycling of the atmosphere, we employed tracer particles as well as tracer fluids after thermodynamic equilibrium was reached.
Results. For the explored parameter space, all simulations eventually reach an equilibrium where heating due to hydrodynamic recycling fully compensates radiative cooling. In this equilibrium, the atmosphere-to-core mass ratio stays well below 10%, preventing the atmosphere from becoming self-gravitating and entering runaway gas accretion. Higher core masses cause the atmosphere to become turbulent, which further enhances recycling. Compared to the core mass, the effect of the headwind on the recycling timescale is negligible. The opacity has no significant effect on the recycling timescale, which demonstrates that the Kelvin-Helmholtz contraction timescale and the atmosphere-disk recycling timescale are independent of each other.
Conclusions. Even for our highest core mass of 10 MEarth, atmosphere-disk recycling is efficient enough to fully compensate for radiative cooling and prevent the atmosphere from becoming self-gravitating. Hence, in-situ formation of hot Jupiters is very unlikely, and migration of gas giants is a key process required to explain their existence. Our findings imply that atmosphere-disk recycling is the most natural explanation for the prevalence of close-in super-Earths and mini-Neptunes.
Le dysfonctionnement mitochondrial, nouvelle cible thérapeutique pour restaurer les réponses immunitaires épuisées contre le VHB
Authors: Clément Léa , Testoni Barbara 
Published: February 2022

Dans le cadre d’un partenariat avec médecine/sciences, et pour la quatrième année consécutive, des étudiants du module d’enseignement « d’immunologie virologie et cancer » du Master de cancérologie de Lyon présentent une analyse d’articles scientifiques récents faisant état d’observations innovantes et importantes. Ce travail a été encadré par des chercheurs confirmés du Centre de Recherche en Cancérologie de Lyon (CRCL). Le Master de cancérologie (université Claude Bernard Lyon1 - VetAgroSup) accueille chaque année 40 étudiants en M1 et environ 80 en M2. Ce master dit « d’excellence » (master international labellisé Université de Lyon) assure aux étudiants de M1 une formation à la cancérologie reposant sur un socle de base commun (biologie cellulaire, moléculaire, immunologie, bio-statistique, épidémiologie, recherche translationnelle, etc.). Les étudiants de M2 peuvent choisir l’un des parcours suivants : 1) Biologie du Cancer ; 2) Innovations thérapeutiques en Cancérologie ; 3) Médecine de précision en Cancérologie ; 4) Cancer Bio-engineering.
Le Master de cancérologie de Lyon repose sur une forte implication des chercheurs et enseignants-chercheurs du laboratoire d'excellence en développement et cancérologie (LabEx DEVweCAN), ainsi que sur un partenariat solide avec plusieurs instituts à travers le monde dont le MIT (Massachusetts Institute of Technology, Cambridge, États-Unis), l'université d'Harvard (Boston, États-Unis), l'université de San Diego (États-Unis), University of City of London (UCL), le Beatson Institute de Glasgow (Royaume-Uni), les universités de Shanghai Jiao Tong (République populaire de Chine, RPC), de Tokyo et de Tohoku (Japon), de Melbourne (Australie) et d'Auckland (Nouvelle-Zélande).
At the source of the polarisation of auroral emissions: experiments and modeling
Authors: Bosse Léo , Lilensten Jean , Gillet Nicolas , Brogniez Colette , Pujol Olivier , Rochat Sylvain , Delboulbé Alain , Curaba Stéphane , Johnsen Magnar Gullikstad 
Published: February 2022

A polarised radiative transfer model (POMEROL) has been developed to compute the polarisation measured by a virtual instrument in a given nocturnal environment. This single-scattering model recreates real-world conditions (among them atmospheric and aerosol profiles, light sources with complex geometries at the ground and in the sky, terrain obstructions). It has been successfully tested at mid-latitudes where sky emissions are of weak intensity. We show a series of comparisons between POMEROL predictions and polarisation measurements during two field campaigns in the auroral zone, in both quiet and active conditions. These comparisons show the strength of the model to assess the aerosol characteristics in the lower atmosphere by using a mesospheric line. They also show that three main upper atmosphere emissions must be polarised: the green atomic oxygen line at 557.7 nm and the 1stN2+negative band at 391.4 nm (purple) and 427.8 nm (blue). This polarisation can be either created directly at the radiative de-excitation or may occur when the non-polarised emission crosses the ionospheric currents. We provide some of the potentialities it offers in the frame of space weather. These require refinements of the preliminary modeling approach considered in the present study.
Clinical Aspects of Dialysis Interventions: Physical and Sonographic Findings
Authors: Niyyar Vandana Dua , Agarwal Anil K. , Salman Loay H. 
Published: February 2022

AbstractPhysical examination (PE) of arteriovenous access remains of high clinical value and continues to be recommended by leading societies and guidelines. PE is easy to learn and perform. Once learned, examiners can provide a comprehensive arteriovenous (AV) access examination in 20 to 30 seconds. Therefore, we continue to advocate that AV access PE should be part of the training for all dialysis care providers. Similarly, ultrasound can provide important AV access evaluation and provide key information. It is relatively cheap and can be readily available at the bed side. Additionally, it is well accepted by patients, as it is not expected to be associated with pain or discomfort during the examination. We present in this review the key components of PE, signs and symptoms of AV access dysfunction, and the role of ultrasound in AV access evaluation as a complementary tool to PE.
Acid form of Trofimenko’s scorpionates, H(Tp
Authors: Saliu Kuburat O. , Cheng Jianhua , McDonald Robert , Takats Josef 
Published: February 2022

We report a re-examination of Trofimenko’s original protocol for the preparation of the acid form of his hydrotris(pyrazolyl)borates, H(TpR,R′), by the treatment of M(TpR,R′) with glacial acetic acid. It is concluded that the protocol is effective as long as the 3-substituent of the pyrazolyl moiety is sufficiently bulky to provide steric protection to the acidic N–H proton. The solid-state structure of H(TptBu,Me), the acid form of the popular TptBu,Me ligand is also presented.
Lexical, exegetical, and frequency-based analyses of the translations of the Qur’anic collocations
Authors: Qassem Mutahar 
Published: February 2022

Abstract
Translating collocations is one of the problematic areas in translation studies, which becomes even more
complicated when translating Qur’anic text is involved. The uniqueness of Qur’anic linguistic features, special context of the Qur’anic
text, and stylistic differences between English and Arabic are barriers to accurate and natural rendition. Along these veins, this
study attempts to investigate seven translations of the Qur’anic noun-noun collocations (Sarwar 1981; Al-Hilali and Khan 1996;
Arberry 1996; Pickthall 1997; Sahih International 1997; Shakir 1999; Ali 2001) to unfold the degree of accuracy and naturalness of
their translations. The present article follows the approach of corpus-based research to study seven prominent translations of the
Noble Qur’an taken from
The Qur’anic Arabic Corpus
, using lexical,
exegetical, and frequency-based analyses, which reveal that integrated lexical and exegetical analyses are perquisites for
adequate rendition and prevent deviation in meaning and translation loss. Frequency-based approach in translation of collocations
could assist in maintaining naturalness of rendition to some extent.
Performance Evaluation of Baseline-dependent Averaging Based on Full-scale SKA1-LOW Simulation
Authors: Deng Qing-Wen , Wang Feng , Deng Hui , Mei Ying , Li Jing , Smirnov Oleg , Guo Shao-Guang 
Published: February 2022

Abstract
The Square Kilometre Array (SKA) is the largest radio interferometer under construction in the world. Its immense amount of visibility data poses a considerable challenge to the subsequent processing by the science data processor (SDP). Baseline dependent averaging (BDA), which reduces the amount of visibility data based on the baseline distribution of the radio interferometer, has become a focus of SKA SDP development. This paper developed and implemented a full-featured BDA module based on Radio Astronomy Simulation, Calibration and Imaging Library (RASCIL). Simulated observations were then performed with RASCIL based on a full-scale SKA1-LOW configuration. The performance of the BDA was systematically investigated and evaluated based on the simulated data. The experimental results confirmed that the amount of visibility data is reduced by about 50% to 85% for different time intervals (

Δ

t

max

). In addition, different

Δ

t

max

have a significant effect on the imaging quality. The smaller

Δ

t

max

is, the smaller the degradation of imaging quality.
Kinematic Simulation and Experimental Research for an Under-actuated Joint Group
Authors: Guo Yaxing , Ou Yangsheng , Zheng Jigui , Jia Longfei , Tao Yunfei 
Published: February 2022

Abstract
Considering the problems of the existing joint group for continuous manipulator, including that it is unrealized to meet the required length of the manipulator and the large bending angle of the joint, a new type of under-actuated linkage joint group is proposed in this paper. The parameterized models of the joint group based on the elastic deformation of the linkage rope and the variable-diameter transmission wheel are established respectively, and the kinematics mapping model of the joint group is derived. Based on the establishment of the model, simulation verification was carried out by applying Adams. Finally, the proposed joint group and kinematics model was verified through experiments. The research results show that the total length of the joint group is 750mm, the maximum movement angle of a single joint in the joint group is greater than 30°, and the maximum movement angle of the joint group is greater than 90°, which improves the maximum movement space and maximum movement angle of the existing joint group. Besides, the joint group can realize the coupling motion of three joints.
Polynomial Phase Signal Denoising Connecting Semantic Information Based on Deep Neural Networks
Authors: Zhang Liang , Hung Cheng-Yu , Yang Hongyu , Huang Rui 
Published: February 2022

Abstract
This paper considers the problem of polynomial phase signal (PPS) denoising. To prove that proper use of semantic information can further improve the denoising performance based on deep neural networks, we propose an architecture combining the segmentation network and the denoising network. The vision semantic information is extracted from the segmentation network first. Then, that information connecting the time-frequency representation of noisy signal are fed into the denoising network for reconstructing signal. To effectively apply the semantic information, three connection strategies and the corresponding lower bound are presented and compared. The proposed method does not require the pre-identification of signal noise conditions and is suitable for a wide range of Signal-to-Noise-Ratio (SNR) scenarios. Simulation results demonstrate that the F1 scores of the spectrum segmentation results are over 0.98 and the proposed method connecting vision semantics for PPS denoising tasks outperforms the baseline and state-of-the-art architectures, when the SNR is larger than -8dB.
ArEnAlg: A Pedagogical Mobile Application for Algorithms Linguistics Based on a Semantic Bilingual Ontology
Authors: Alnahdi Amany K , Aboalela Rania A , Khazmari Rasha K. , Baothman Fatmah A , Babour Amal J , Al Taisan Huda A 
Published: February 2022

Abstract
Ontologies are knowledge structures that serve as the foundation for semantic applications. These semantic artifacts organize and classify knowledge to define the semantic relations among the concepts. Some ontologies are constructed for a single natural language, whereas others are built for dual or multi-natural languages. The goal of this study is to design and implement a mobile educational application to help students learn more effectively and to increase the learner’s acquisition of computational linguistics in the Algorithm domain. The methodology is to develop an application with unique features that can display the terms and the concepts in both Arabic and English languages in two different layouts: a list form and a flashcard form. The created app “ArEnAlg” can generate the terms in the algorithm domain. The major objective of the exercise modules is to examine the user’s knowledge of the concepts in the domain of algorithms. The evaluation results tested three factors: the learner’s enjoyment, the acquisition of the computational linguistics, and the application presentation, which showed that behavioral responses support the purpose of the developed application with a max-min range of 99% -81%.
The impact of additive usage on motorcycle CO and CO2 emission
Authors: Wardoyo Arinto Y.P. , Johan  , Noor A.E. , Alwansyah Mohammad Hisyam , Adi Eko T. P. , Budianto Arif 
Published: February 2022

Abstract
A fuel additive has been believed to raise engine performance by increasing fuel efficiency. However, a study about the influence of fuel additives on CO and CO2 emission has not been clearly understood yet. In this study, we investigate the influence of fuel additives on CO and CO2 motorcycle emission. Ten different additives: Bio additives and synthetic additives mixed with gasoline with RON of 90 used to operate a standard 100 cc motor engine. The additive concentration was determined by using the factory recommended dose. The engine was activated for 100 seconds during the smoke collection procedure. The smoke was collected into a measurement chamber with a dimension of (20 × 30 × 20) cm3. The CO and CO2 concentrations were measured by using Q-Trak Indoor Air Quality Monitor 7575. The remaining fuel was drained after the measurement to calculate the consumed one. In the result, the bio-additive produced CO2 of (0.44 × 103 - 2.76 × 103) ppm and synthetic additive of (0.12 × 103 - 1.48 × 103) ppm. On the other hand, the bio additive produced CO of (0.12 × 103-1.11 × 103) ppm while the synthetic produces (0.12 × 103-1.11 × 103) ppm. The bio and synthetic additive CO2 emission factors were calculated of (0.28–8.01) ppm/ml fuel and (0.88-13.17) ppm/ml. For CO, the emission factor was obtained of (0.48–8.93) ppm/ml and 0.29 ppm/ml -4.08 ppm/ml for bio and synthetic additive, respectively. In conclusion, using bio-additives produced more CO2 and CO emissions on the motorcycle.
Influence of thickness on heat treatment from 300 to 1100 K of aluminum thin film
Authors: Susila Anggara Budi , Handoko Erfan , Budi Esmar , Budi Agus Setyo 
Published: February 2022

Abstract
We investigated the influence of Aluminum thin film thickness during heat treatment. The films with thickness of 5 nm, 10 nm and 15 nm were heated from room temperature up to above melting point with same heating rate. Molecular Dynamics (MD) simulation is employed to study the behaviour of the thin film where the atoms were followed based on its trajectories. Thin film thickness gives significance contribution to the mechanism of the melting. Smaller thickness suffered strong pressure oscillation while the thin film temperature is increases. Local crystal structure confirmed the transformation of the system from crystalline state to melting state.