bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Meteorological and Hydrological Conditions on Nutrient Losses from Agricultural Areas in Latvia
Authors: Siksnane Ieva , Lagzdins Ainis 
Published: July 2022

Abstract
Water quality in any stream is affected by complex interactions between natural and anthropogenic factors in a given catchment area. Agriculture has been identified as a major contributor of nitrogen and phosphorus inputs to surface waters in the Baltic Sea region. Although decisions regarding agricultural management practices, e.g. crop rotation, tillage, fertilization, have a direct impact on likelihood and magnitude of nitrogen and phosphorus losses from agricultural areas to surface waters, natural factors such as meteorological and hydrological conditions have a triggering role in processes determining transformations, storage, uptake and losses of nutrients. In order to investigate the effects of meteorological (precipitation and air temperature) and hydrological (runoff) conditions on water quality (losses of total nitrogen (TN) and total phosphorus (TP)) the results of the Agricultural Runoff Monitoring Programme collected at three monitoring sites (Berze, Mellupite, and Vienziemite) during the time period of 1995–2020 were summarized and analysed. The pronounced differences in mean annual air temperature and annual precipitation were observed when the meteorological information representing the periods of twenty years was compared indicating for evidences of climate change. In addition, the relationships between seasonal precipitation and runoff was detected. As affected by the hydrological behaviour the losses of TN and TP in agricultural catchments had large variations depending on the intensity of agricultural production and site location. The changes in seasonal and annual patterns of precipitation, air temperature and runoff may increase the risks of nutrient losses from agricultural catchments in the future.
Reduced expression of neurogenesis genes as biomarkers of Parkinson's disease associated with mutations in the <i>GBA</i> gene: validation of the data analysis of transcriptome study
Authors: Bezrukova A. I. , Basharova K. S. , Miliukhina I. V. , Timofeeva A. A. , Senkevich K. A. , Pchelina S. N. , Usenko T. S. 
Published: July 2022

The objective of the study was to validate our previous results obtained during the transcriptome analysis of the primary culture of peripheral blood macrophages in patients with Parkinson's disease associated with mutations in the GBA gene (GBA-PD) in that reduced expression of the neurogenesis genes EGR1 (early growth response protein 1), NR4A2 (nuclear receptor 4A2), JUNB (transcription factor jun-B) in patients with GBA-PD.Methods and materials. The study included 14 patients with GBA-PD, 15 GBA-carriers, 30 patients with Parkinson's disease (PD) and 44 persons of the control group. The assessment of relative mRNA level of neurogenesis genes EGR1, NR4A2, JUNB in peripheral blood mononuclear cells were carried out by real-time quantitative polymerase chain reaction (PCR) using TaqMan fluorescent probes or EvaGreen fluorescent DNA dye.Results. Relative mRNA level of the JUNB gene in peripheral blood mononuclears was decreased in the group of patients with GBA-PD compared to controls (p=0.034). We found out that the relative mRNA level of the NR4A2 gene in peripheral blood mononuclears was increased in the group of patients with GBA-carriers compared to GBA-PD, patients with PD and controls (p=0.0029, p=0.00045, p=0.0024 respectively). There were no statistically significant differences in the mRNA level of the EGR1 gene between all the study groups (p>0.05).Conclusion. GBA-PD is characterized by reduced expression of the JUNB gene compared to control and of the NR4A2 gene compared to GBA-carriers.
<i>FABP4</i> gene expression in subcutaneous and visceral adipose tissue in patients with obesity and type 2 diabetes mellitus
Authors: Dracheva K. V. , Pobozheva I. A. , Anisimova K. A. , Hamid Z. M. , Sapojnikova A. P. , Balandov S. G. , Vasilevsky D. I. , Pchelina S. N. , Miroshnikova V. V. 
Published: July 2022

Introduction. Obesity is associated with a high risk of developing concomitant diseases such as: metabolic syndrome, type 2 diabetes mellitus (DM2), cardiovascular pathology. FABP4 (fatty acid binding protein) is the specific lipid chaperone and an important protein for the function of adipose tissue and is one of the adipocytokines secreted by adipose tissue.The objective of the study was to investigate the FABP4 gene expression in subcutaneous and visceral adipose tissue (SAT and VAT) in patients with obesity and DM2.Methods and materials. SAT and VAT samples were obtained during bariatric surgery (N=43, BMI>35): obese with DM2 (N=21), obese without DM2 (N=22). Samples for the control group without obesity (N=15, BMI<30) were obtained during planned operations on the abdominal cavity. FABP4 mRNA level was estimated by real-time PCR.Results. It has been demonstrated that the mRNA level of the FABP4 gene in SAT and VAT is reduced in obesity, regardless of the manifestation of DM2 (p<0.01). A negative correlation was observed between the mRNA level of the FABP4 gene in adipose tissue and the BMI index (for SAT: r=—0.327, p = 0.016; for VAT: r=—0.304, p = 0.024).Conclusion. The expression level of FABP4 gene in AT can act as a marker of AT dysfunction in obesity.
Morphological features of complicated gastroduodenal ulcers
Authors: Osmanov Z. H. , Rybakova M. G. , Tikhonova Yu. A. , Semenov D. Ju. , Korolkov A. Yu. , Mylnikova A. A. 
Published: July 2022

The objective of the study was to evaluate structural changes in the margin of gastroduodenal ulcers complicated by perforation, bleeding or penetration in terms of the features of ulcer healing.Methods and materials. Histological and IHC studies were performed on 25 patients of the main group with perforated gastroduodenal ulcers and 23 patients of the control group with chronic recurrent ulcers complicated by bleeding and penetration. Histological sections were stained with hematoxylin and eosin, and Van Gieson's picrofuchsin. Immunohistochemical reactions were performed with antibodies to Ki-67, CD68, CD138, and CD34.Results. On macroscopic evaluation, a clear even margin of the perforation was noted. Histological examination with the background of acute dyscirculatory changes clearly shows a zone of necrosis and a weakly expressed layer of granulation tissue, which in majority of the cases was practically absent. The margin of a perforated ulcer consists of a minimally presented, clearly delimited zone of tissue detritus and a practically unchanged muscle layer. Plasma cells dominated in the cell infiltrate, and the index of proliferative activity in the epithelium of the ulcer margins was about 45 %, distributed fairly evenly.Conclusions. Perforated ulcers can be considered as a special group of ulcers with the most pronounced changes of infiltration by plasmatic cells and eosinophils, edema and acute dyscirculatory changes, uniform and fairly high proliferative activity of the epithelium. Changes in the margins of the perforated ulcer allow for complete regeneration without excessive scarring with precise suturing of the perforation.
Reasons for not prescribing anticoagulants in hospitalized patients with atrial fibrillation and high risk of stroke: what should be the optimal management tactics for these patients?
Authors: Baranova E. I. , Bliznyuk O. I. , Pavlova V. A. , Skuridin D. S. , Kolesnik O. S. , Katsap A. A. 
Published: July 2022

The objective of our study was to determine the reasons for not prescribing anticoagulant therapy (ACT) in the therapeutic department of university clinic for patients with atrial fibrillation (AF) and a high risk of stroke and to discuss the optimal management of these patients.Methods and materials. A retrospective analysis of 1307 case histories of AF patients admitted to a university therapeutic clinic from 2014 to 2018 presented. The reasons for not prescribing ACT to patients with AF and high risk of stroke and optimal ACT discussed.Results. ACT was not prescribed to 109 (9.7 %) hospitalized patients out of 1128 patients with AF without prosthetic valves and mitral stenosis who had a high risk of stroke ((4.5±1.1) points on the CHA2DS2VASc scale). The risk of bleeding – (1.6±0.1) (HAS-BLED). The age of patients was (73.8±10.4) years. From 2014 to 2018, the frequency of unjustified non-prescribing ACT decreased by 3.7 times – from 47/205 (22.9 %) in 2014 to 11/178 (6.2 %) in 2018 (p=0.001). In general, over 5 years of observations, subjective reasons for not prescribing ACT were: lack of stroke risk assessment (78.0 %), senile age of patients and the presence of dementia (42.2 %), the first paroxysm of AF (22.9 %) during myocardial infarction and heart surgery, planned surgical treatment, effective radiofrequency ablation and patient refusal. Objective (usually transient) reasons for not prescribing ACT were: severe and moderate anemia (24.8 %), recent bleeding (11.9 %), gastrointestinal diseases predisposing to bleedings (9.2 %), oncology (12.8 %), end-stage chronic kidney disease (2.8 %), thrombocytopenia (2.8 %). Often various reasons for not prescribing ACT were combined.Conclusion. In patients with AF and a high risk of stroke, the incidence of not prescribing ACT decreased by 3.7 times from 2014 to 2018. In 2014, the most common reasons for not prescribing ACT were the lack of stroke risk assessment and the senile age of patients, and in 2017–2018 senile age, the first paroxysm of AF, effective radiofrequency ablation, anemia, recent bleeding, and gastrointestinal diseases predisposing to bleedings.
Load Reduction During Resonance Crossing of a Variable-Speed Rotor
Authors: Chandrasekaran Ruthvik , Hodges Dewey H. 
Published: July 2022

The efficiency of the rotorcraft could be improved significantly by varying the speed of the rotor based on the flight condition. Due to this reason, variable-speed rotor (VSR) technology is becoming popular, especially among urban air mobility vehicles. However, one of the biggest challenges of a VSR is the vibration of the rotor blade when it passes through a resonance point. A detailed study on the characterization of these resonances was performed by the authors (“Performance Advantages and Resonance Analysis of a Variable Speed Rotor Using Geometrically Exact Beam Formulations,” Journal of American Helicopter Society, Vol. 67, May 2022, Paper 042006). In this study, methods of reducing loads during resonance crossings are explored. The rotor model is built in Dymore, which is a multibody dynamics simulation tool. The geometrically exact beam theory is used to model the rotor blades as one-dimensional beams. Peters et al.’s (“Finite State Induced Flow Models Part I: Two-Dimensional Thin Airfoil,” Journal of Aircraft, Vol. 32, No. 2, March–April 1995, pp. 313–322) unsteady aerodynamics model with finite-state inflow and dynamic stall is used to obtain the aerodynamic loads acting on the rotor. Load reduction studies were carried out by varying the transition time, structural damping, and lag stiffness of the blade. The longer the rotor took to traverse a resonance region, the greater were the resonance loads. However, there were torque limitations on how quickly a rotor could pass through resonance. Increasing the structural damping was a very effective way of reducing the resonance loads. Increasing the lag stiffness of the rotor blade deteriorated the torque response due to 4/rev crossings. Combination studies were performed by combining the ideal transition times with 7% lag damping.
The safety and efficacy of closed reduction and percutaneous pinning with an intraoperative arthrogram for Grade 2 and Grade 3 pediatric lateral condyle fractures
Authors: Al-Naseem Abdulrahman , Al-Shehawy Haytham M. , Khaja Aliaa F. , Awad Mohammad , Hammady Wael K. , Alkandari Asmaa , Nasri Tareq , Al-Saifi Saleh 
Published: July 2022

Objectives:
It is controversial whether pediatric lateral humeral condyle fractures (LHCFs) with >2 mm displacement can be managed using closed reduction and percutaneous pinning (CRPP) as opposed to open reduction. This study assesses the clinical, radiographic outcomes, and complication rates of patients undergoing arthrogram-assisted CRPP for fractures with >2 mm of displacement rather than open reduction and internal fixation.

Methods:
This study was conducted retrospectively, looking at all children presenting acutely with LHCFs that were displaced >2 mm between January 2017 and December 2019 whom one surgeon treated within 48 hours of the initial injury. Sixteen patients met the inclusion criteria. Pre-operative and post-operative anteroposterior as well as lateral radiographs were used to measure displacement and classify fractures. A subgroup analysis was done to compare the results in Grade 2 and 3 fractures as per Weiss classification.

Results:
Signs of union were observed in all patients at 2 weeks and all fractures were healing well at 6-week follow-up, regardless of fracture grade or displacement. Post-operative complications including pin site infections, valgus deformity, non-union, or malunion were not seen. A higher proportion of Grade 3 patients developed heterotrophic ossification and limitation of range of movement.

Conclusion:
Arthrogram imaging is a valuable tool to help visualize the articular cartilage surface and determine the suitability of CRPP for LHCF with >2 mm displacement. It is a safe option with good outcomes and provided that there is no significant articular cartilage incongruity seen under fluoroscopy.
Potential transformation of baduy local wisdom values in civics education learning in elementary school
Authors: Elan Elan , Solihati Elis 
Published: July 2022

Indonesia has diverse values rooted in local wisdom, for instance, the local wisdom of the Baduy ethnic group. Baduy local wisdom has the potential values to be a transformation source in Civics Education learning. This study aimed to describe the potential transformation of Baduy local wisdom in Civics Education learning. A case study, a qualitative approach was employed in this study. This research is located at elementary schools around Citorek district, Lebak, Banten. The data was obtained through interviews, observations, and documentation. The results showed that Baduy local wisdom taught lessons to be a good citizen because it contains the following values: <em>first</em>, Baduy local wisdom forms the basic human characters of children aged 6 to 12 years. <em>Second: </em>Baduy teachings are universal and religious to shape children's morality,, especially boys. The revitalization of the values of Baduy cultural tradition needs to be transformed by today's young generation in their social life. These values can be transformed in the learning process of Civics education. One of the efforts made is through strengthen the ability of teachers to design the lesson plans, syllabus, and learning methods that were adapted to the context of deep local wisdom values.
Mekanisme Penyelesaian Sengketa Penyedia Jasa Website Download Film Gratis Bagi Pencipta Film di Indonesia
Authors: Putera Yonatan Andreas , Djaja Hendra , Adyana I Gusti Ngurah , Ariyanti Ariyanti 
Published: July 2022

Copyright infringement can have a negative impact on film makers both materially and morally. Coupled with the development of the internet, copyright infringement is not only realized in the form of pieces of VCD / DVD, but has penetrated into the internet media, namely the emergence of many websites or sites that provide free movie download services. The creators of these films and websites do not have a definite legal relationship. The emergence of these websites is of course very detrimental to the film creator because these websites operate illegally without any relationship agreement or agreement from the film creator and for the personal benefit of the website owner without thinking about the losses experienced by the film creator. But the creator can also report these websites if they feel aggrieved and of course if it is indeed proven to be carrying out illegal activities against the copyrighted films of the creator of the film. If it is proven to have committed an unlawful act, the website owner may be subject to sanctions in the form of prison or other compensation such as compensation for royalties. This research uses normative legal research with the aim of discussing how the dispute resolution mechanism between film creators and film website service providers.
Penyalahgunaan serta proses Penyelesaian Visa Kunjungan oleh Warga Negara Asing
Authors: Sitanggang Dicky Agustinus , Santoso Muhari Agus , Nahuddin Yusuf Eko , Rifandana Raditya Feda 
Published: July 2022

This research is related to the process of resolving the misuse of visas carried out by foreign nationals in Indonesia. The purpose of this study is to find out the Process for the Settlement of Misuse of Visit Visas Performed by Indonesian Citizens in the implementation of the Settlement of Misuse of Visit Visas that have been carried out by Foreign Citizens, hereby implementing and providing the right impact on Foreign Citizens. The method of collecting data is directly conducting interviews with informants related to the completion process of Visit Visa Abuse. The method used is using empirical research methods with the transformation process of research data sourced from directly related informants. In this case, there is the implementation of the Visit Visa Abuse Settlement Process carried out by Foreign Citizens, there are still several obstacles and shortcomings, both in terms of supervision and the role of Immigration office employees in Indonesia.
MRI study of cerebroprotective effects of renal denervation in patients with resistant hypertension and type 2 diabetes mellitus
Authors: Falkovskaya A. Yu. , Sukhareva A. E. , Pekarskiy S. E. , Zyubanova I. V. , Manukyan M. A. , Tsoi E. I. , Khunkhinova S. A. , Vtorushina A. A. , Mordovin V. F. 
Published: July 2022

Objective. To assess the changes in subclinical MRI signs of brain damage in relationship with the changes in blood pressure, proinflammatory cytokines, and endothelial function one year after renal denervation (RDN) in patients with resistant hypertension (RHTN) and type 2 diabetes mellitus (T2DM).Material and Methods. The prospective interventional study (ClinicalTrials.gov identifiers NCT02667912 and NCT01499810) analyzed qualitative brain MRI imaging data from 39 patients with RHTN and T2DM. All patients underwent 24-h ambulatory blood pressure monitoring (ABPM), brain MRI scan (1.5 T), blood tests for high-sensitivity C-reactive protein (hsCRP), and brachial artery flow-mediated dilation (FMD) measurements by high-resolution ultrasound. Patients were taking an average of 4.5 (3–6) antihypertensive drugs and were instructed not to change the therapy regimen throughout the study. A total of 29 patients completed the one-year follow-up.Results. A significant decrease in average daily systolic/diastolic blood pressure by 12 [95% CI 4.1; 19.8]/5.9 [95% CI 0.4; 11.3] mmHg (p = 0.004/0.038) according to 24-h ABPM, increase in FMD (p = 0.008), and a decrease in hsCRP level (p = 0.04) were observed one year after RHTN. Over half of patients (57%) had a decrease in 24-h systolic blood pressure by ≥ 10 mm Hg; target level of blood pressure was achieved in 38% patients. No changes in the MRI signs of brain damage (linear dimensions of liquor systems, white matter lesions [WMLs], brain damage MRI score, and intensity of MRI signal from the basal nuclei and WMLs) were observed except for a decrease in the severity of liquorodynamic disturbances. Reduction or stabilization of WML degree was observed in 24 patients (86%). No relationships were found between the dynamics of WMLs and the changes in blood pressure, FMD, and hsCRP.Conclusion. Administration of RDN to patients with RHTN and T2DM allowed to limit the WMLs in most cases and reduce the severity of liquorodynamic disorders during one-year of follow up.
Expression of oxidative stress markers in native heart valves obtained from patients with infective endocarditis
Authors: Sinitskaya A. V. , Sinitsky M. Yu. , Khutornaya M. V. , Kazachek Ya. V. , Evtushenko A. V. , Ponasenko A. V. 
Published: July 2022

Aim. To evaluate the contribution of SOD1, CAT, PXDN1, NOS3, EDN1, VCAM, ICAM, PECAM, SELE and SELP genes to the pathogenesis of infective endocarditis in patients undergoing cardiac surgery.Material and Methods. We studied 25 native heart valves obtained from patients with infective endocarditis and 13 native heart valves obtained from patients with other valvular pathology. The expression of SOD1, CAT, PXDN1, NOS3, EDN1, VCAM, ICAM, PECAM, SELE and SELP genes was determined by qPCR. Immunofluorescent staining was performed using specific primary antibodies to nitrotyrosine.Results. Native heart valves obtained from infective endocarditis patients were characterized by the decreased expression of genes involved in the processes of oxidative stress and genes encoding cell adhesion molecules. Immunofluorescence staining showed that the heart valves obtained from infective endocarditis patients had lower nitrotyrosine staining compared to the control suggesting the decreased oxidative stress.
vítimas da tragédia de Mariana/MG
Authors: Oliveira Antônio Leal de , Nascimento Manuela Andrade do 
Published: July 2022

CONTEXTO: Esta pesquisa é fruto do Programa de Iniciação Científica da Faculdade de Direito de Vitória (FDV) e teve como base o rompimento da barragem de Fundão, Mariana - MG, e seus desdobramentos no que tange a reparação de danos aos afetados.
OBJETIVO: O objetivo principal do trabalho é analisar como a forma de elaboração do chamado “TAC-Governança”, considerado um marco para a (re)estruturação do sistema de reparação de danos causados pelo desastre de Mariana, corrobora para a manutenção dos afetados em um ciclo de esquecimento permanente, considerando a Teoria da Memória de Walter Benjamin e os pontos levantados pelos próprios atingidos no Parecer Técnico nº 279/2018, realizado pela Secretaria de Perícia, Pesquisa e Análise, do MPF e pela Coordenadoria de Inclusão e Mobilização Sociais, do MP-MG.
MÉTODO: Utilizando-se do método hipotético-dedutivo e contando com as técnicas de pesquisa bibliográfica e análise documental, foi trabalhada a hipótese de que o “TAC-Governança”, elaborado para reparar os danos suportados pelos atingidos, é insuficiente para dar conta das consequências do desastre de Mariana, propondo uma análise crítica a não-inclusão dos afetados no momento de construção e elaboração do referido ajuste, a partir da perspectiva do oprimido.
RELEVÂNCIA/ORIGINALIDADE: Tanto a relevância, como a originalidade da pesquisa, está concentrada na análise do desastre de Mariana, e da “solução jurídica” elaborada para promover a reparação de danos, a partir da perspectiva dos afetados com base na Teoria da Memória benjaminiana, matriz teórica essa que revela o viés de teoria crítica utilizado no artigo.
RESULTADOS: A intersecção entre a teoria benjaminiana e o direito possibilita que seja ressaltada a importância do reconhecimento das vivências dos atingidos, uma vez que é a partir da perspectiva de quem sofreu, e ainda sofre, com as consequências diretas e indiretas do desastre que será possível desenvolver uma reparação mais eficaz dos danos.
CONTRIBUIÇÕES TEÓRICAS/METODOLÓGICAS: As contribuições teóricas alcançadas no desenvolvimento do artigo conduzem o leitor à necessidade de se aplicar o direito de forma atenta, inclusiva e compassiva para com àqueles que foram, por alguma ou por várias razões, silenciados, pois é a partir da perspectiva dos oprimidos que será possível “fazer justiça”.