bluuebunny/crossref_metadata_2025_split huggingface dataset:
Instantaneous wave‐free ratio‐guided revascularization of nonculprit lesions in STEMI patients with multivessel coronary disease: The WAVE registry
Authors: Musto Carmine , Scappaticci Massimiliano , Biondi‐Zoccai Giuseppe , De Felice Francesco , D'Amario Domenico , Nazzaro Marco S. , Stio Rocco E. , Del Prete Armando , Chin Diana , Pennacchi Mauro , Paolucci Luca , Versaci Francesco , Gabrielli Domenico 
Published: July 2022

AbstractBackgroundComplete revascularization (CR) of nonculprit lesions (NCL) is strongly recommended in patients with ST‐elevation myocardial infarction (STEMI) and multivessel coronary artery disease (MVD), but no definitive evidence is available regarding which diagnostic strategy should be preferred. Instantaneous wave‐free ratio (iFR) has never been investigated in this setting. We aimed to describe clinical outcomes of a cohort of patients undergoing iFR‐guided CR.MethodsFollowing primary percutaneous coronary intervention (PCI), consecutive patients with STEMI and intermediate NCL were enrolled and destinated to an iFR‐guided CR. NCL with iFR ≤ 0.89 underwent PCI while NCL with iFR > 0.89 were deferred. The primary endpoint was NC target lesion failure (NC‐TLF) and the secondary endpoint was major adverse cardiovascular events (MACE), at 1‐year follow‐up.ResultsOverall, 209 patients were enrolled (ischemic iFR = 83; nonischemic iFR = 126). Patients with ischemic iFR showed a higher prevalence of traditional cardiovascular risk factors and angiographically determined three‐vessel disease. In the entire cohort, NC‐TLF and MACE occurred in 6.7% and 10.5% of patients, respectively. Compared to the deferred group, patients with ischemic iFR experienced significantly higher rates of both NC‐TLF (3.2% vs. 12.1%; p = 0.021) and MACE (7.1% vs. 16.9%; p = 0.041). These results were mostly driven by increased rates of NC‐TLF PCI and further revascularizations in this latter group, while no differences were evident in terms of nonfatal myocardial infarction or death. At multivariable analysis, the strongest predictor of MACE was symptom onset to balloon time (HR = 1.17 [95% CI: 1.04–1.31], p = 0.008).ConclusionsIn our study enrolling STEMI patients with MVD, iFR assessment was feasible and safe. PCI‐deferring according to iFR evaluation of NCL was associated with low rates of adverse events. Further randomized studies are needed to investigate the effectiveness of iFR‐guided revascularization compared to current practice in this setting.
Radial access for chronic total occlusion percutaneous coronary intervention: Insights from the PROGRESS‐CTO registry
Authors: Simsek Bahadir , Gorgulu Sevket , Kostantinis Spyridon , Karacsonyi Judit , Alaswad Khaldoon , Jaffer Farouc A. , Doshi Darshan , Goktekin Omer , Kerrigan Jimmy , Haddad Elias , Patel Mitul , Rinfret Stephane , Jaber Wissam A. , Nicholson William , Abi Rafeh Nidal , Allana Salman , Koutouzis Michalis , Brilakis Emmanouil S. ,   PROGRESS‐CTO investigators
Published: July 2022

AbstractUse of radial access for chronic total occlusion (CTO) percutaneous coronary intervention (PCI) has been increasing. We examined the clinical characteristics and procedural outcomes of patients who underwent CTO PCI with radial versus femoral access in the Prospective Global Registry for the Study of CTO Intervention (PROGRESS‐CTO, NCT02061436). Of 10,954 patients who underwent CTO PCI at 55 centers in 7 countries between 2012 and 2022, 2578 (24%) had a radial only approach. Patients who underwent radial only access were younger (63 ± 10 vs. 65 ± 10, years, p < 0.001), more likely to be men (84% vs. 81%, p = 0.001), and had significantly lower prevalence of comorbidities compared with the femoral access group including diabetes mellitus (39% vs. 45%, p < 0.001) and coronary artery bypass graft surgery (57% vs. 64%, p < 0.001). In addition, radial only cases had lower angiographic complexity with lower J‐CTO and PROGRESS‐CTO scores. After adjusting for potential confounders, radial only access was associated with lower risk of access site complications (odds ratio [OR]: 0.45, 95% confidence interval [CI]: 0.22–0.91), similar technical success (OR: 0.87, 95% CI: 0.74–1.04) and major adverse cardiovascular events (MACE) (OR: 0.65, 95% CI: 0.40–1.07), compared with the femoral access group. Radial only access was used in 24% of CTO PCIs and was associated with lower access site complications, and similar technical success and MACE as compared with the femoral access group.
Complete uniparental disomy of chromosome 1 in a child with isolated developmental delay
Authors: Wallerstein Violet , Grant Leon , Wallerstein Robert 
Published: July 2022

AbstractComplete uniparental disomy of chromosome 1 (UPD1) is an uncommon genetic finding about which a specific phenotype has not yet been established. We present a boy who has complete paternal UPD1 and isolated developmental delay and suggest that there is no clear phenotype of UPD1.
Promising effects of corticosteroid treatment in combination with antifungal agents in a patient with Aspergillus meningitis
Authors: Jalali Parisa Aziz , Lotfali Ensieh , Rezaei Kamran , Fatemi Alireza , Ashrafi Farzad , Oraee‐Yazdani Saeed , Mirdehghan Alimohammad 
Published: July 2022

AbstractAlthough Aspergillus meningitis is poorly responsive to current guidelines for treatment, we describe a dramatic response of Aspergillus meningitis in a patient to treatment using a combination of corticosteroids with guideline’s suggested antifungal agents. Administration of corticosteroids in patients with Aspergillus meningitis is rarely reported in previous studies.
Unusual presentation of familial Mediterranean fever with co‐existing polyarteritis nodosa and acute post‐streptococcal glomerulonephritis
Authors: Özdemir Atikel Yeşim , Derinkuyu Betül Emine , Bakkaloğlu Sevcan A. 
Published: July 2022

AbstractAcute post‐streptococcal glomerulonephritis (APSGN) and polyarteritis nodosa (PAN) may occur simultaneously after streptococcal infection in a child who is previously healthy but carries a Mediterranean fever (MEFV) mutation. The homozygous M694V mutation in the MEFV gene may cause an augmented response to the streptococcal infection that plays a role in the development of both clinical manifestations.
Allergic bronchopulmonary mycosis characterized by chest pain and high‐attenuation mucus on computed tomography
Authors: Hirata Risa , Tago Masaki , Makio Seijiro , Oishi Toru , Oda Yoshimasa 
Published: July 2022

AbstractA 45‐year‐old woman developed chest pain on the previous day. High‐attenuation mucus in the bronchus was found on the CT examination on admission, which led to a diagnosis of allergic bronchopulmonary mycosis. CT should be checked carefully for high‐attenuation mucus because this finding is highly specific for allergic bronchopulmonary mycosis.
An unusual case of multiple gastrointestinal stromal tumors in the small bowel presenting as occult and overt gastrointestinal bleeding
Authors: Yeaman Fiona , Abasszade Joshua , Varma Poornima , Swan Michael 
Published: July 2022

AbstractWe present a case report of a 59‐year‐old woman with multiple gastrointestinal stromal tumors as a cause of gastrointestinal bleeding. She initially presented with recurrent iron deficiency anemia and subsequent gastrointestinal bleeding over 10 years. An initial angiodysplastic lesion was identified, treated, and spot tattooed. Recurrent symptoms occurred leading to repeat investigations with a further subepithelial lesion with ulceration being identified. Computerized tomography enterography subsequently revealed an ileal intraluminal enhancing lesion, and she was referred to surgery. Surgical resection was ultimately performed, and multiple lesions were found to be present with histology revealing multiple gastrointestinal stromal tumors.
When muscle quivers and undulates
Authors: Rebello Alex , Asif Mohd , Dhanusha Kumbha , Haritha Bandi , Narmada Nangadda , Poudel Ram Chandra 
Published: July 2022

AbstractWe describe a patient who presented with fatigue and pulling sensation in his lower limbs. He had continuous muscle contractions over his trunk (myokymia) which pointed towards the diagnosis of Isaacs syndrome which was confirmed by strongly positive CASPR2 antibodies in blood.
Three cases of brain hydatidosis in North Khorasan, Iran
Authors: Shafiei Reza , Raeghi Saber , Jafarzadeh Fatemeh , Najjari Mohsen , Ghatee Mohammad Amin , Shokri Azar 
Published: July 2022

AbstractCystic hydatidosis is a serious public health problem in Iran. Although cysts can develop in almost all organs and the brain cysts are very rare. Here, we present 3 confirmed cases of brain hydatidosis and the patients who underwent successful surgery. Pathological examinations demonstrated the presence of cystic hydatidosis.
Lyonia ovalifolia (Angeri) poisoning: A case report
Authors: Sharma Niraj Kumar , Bhattarai Madhur , Shah Sangam , Gyawali Pawan , Baral Kushal , Banstola Hemanta 
Published: July 2022

AbstractLyonia ovalifolia (angeri) is a deciduous tree whose shoot and leaves are toxic. Its chemical constituents include grayanane diterpenoids, lyoniol A, and other toxic compounds. Young children might consume it intentionally or unintentionally, with subsequent adverse health outcomes and even mortality depending on the amount ingested. We present a case of an adolescent girl who developed poisoning on ingestion of angeri leaves.
Pregnancy management for a woman with extensive vulvar and pelvic malformations caused by Klippel–Trénaunay syndrome
Authors: Hofmann Konstantin , Macchiella Doris , Kloeckner Roman , Hasenburg Annette 
Published: July 2022

AbstractKlippel–Trénaunay syndrome (KTS) is a rare congenital disorder defined by a triad of capillary malformation, venous malformation, and soft tissue or bone hypertrophy most commonly affecting unilateral lower limbs. Due to the rarity of KTS, evidence‐based guidelines for the management of pregnancy in people with KTS are still lacking. A 34‐year‐old woman (gravidity 1; parity 0) presented at 25 weeks of gestation with malformations of the right side of her body. The extent of the KTS affecting the vulva, pelvis, and right leg was remarkable. As the prenatal MRI showed massive vascular malformations of the pelvis and vulva, we performed an elective cesarean section to avoid severe perinatal hemorrhage during a vaginal delivery. Intraoperatively, we observed varices on the parietal peritoneum within the vesico‐uterine pouch and the isthmocervical transition of the uterus, which were not identifiable in the preoperative MRI. Although KTS patients have been discouraged from pregnancy in the past because of a high risk for complications, successful and uncomplicated pregnancies are possible. For this purpose, we believe a multidisciplinary strategy that is crucial.
Fluorine‐Doping Strategy To Improve the Surface and Electrochemical Properties of LiNi0.6Co0.2Mn0.2O2 Cathodes for Use in Lithium‐Ion Batteries
Authors: Wang Wencong , Lee Changhee , Miyahara Yuto , Abe Takeshi , Miyazaki Kohei 
Published: July 2022

AbstractThis study sought to achieve fluorine doping into the surface structure of LiNi0.6Co0.2Mn0.2O2 (NCM622) cathodes for use in lithium‐ion batteries by the atomic layer deposition method to improve structural stability and electrochemical performance. Thin‐film electrodes were used to clearly understand the fundamental effects of surface properties. Based on our observations, the oxygen vacancy that basically exists in the surface of the NCM622 thin‐film electrode triggers the additional formation of oxygen derivatives with a spinel‐like phase, leading to poor cycling stability and severe deterioration of the surface structure. Contrary, the fluorinated NCM622 thin‐film electrode exhibits improved electrochemical properties including satisfactory cycling stability, which benefits from the higher binding energy of fluorine that positively influences the stability of the surface oxygen layer by being doped into the unstable oxygen site, and thus the formation of oxygen derivative phases is successfully suppressed during electrochemical reactions.
Construction of Photo‐Responsive Pd2L4‐Type Nanocages based on Feringa's Second‐Generation Motor and Its Guest Binding Ability for C60
Authors: Qin Yunan , Xiong Jingpeng , Li Quan , Zhang Yuexing , Zeng Ming‐Hua 
Published: July 2022

AbstractWe present the construction of a M2L4‐type metal‐organic nanocage featuring four endohedral Feringa's motor motifs and its adaptive encapsulation towards a C60 guest molecule. The structure of the cage, though complicated on the 1H NMR spectrum due to the adoption of mixed ligands, was unambiguously characterized with a combination of ESI‐MS, 2D DOSY, 13C NMR and particularly the SAXS technique. The molecular motor within the cage demonstrated similar photophysical properties to the uncoordinated one, indicating the motor's function was not compromised when it was anchored in such a confined nanospace. Furthermore, the nanocage showed good guest encapsulation ability towards C60, and a guest induced‐fit behavior of the cage was revealed based on the extensive SAXS analysis and molecular dynamics simulation. The adaptive motorized nanocage reported here represents one of the very few examples of integrating individual motors into a discrete nanoconfined system and offers prospects to achieve its non‐equilibrium functions.
Iron‐Catalyzed Cross‐Coupling of Thioesters and Organomanganese Reagents**
Authors: Geiger Valentin Jacob , Lefèvre Guillaume , Fleischer Ivana 
Published: July 2022

AbstractWe report a Fukuyama‐type coupling of thioesters with aliphatic organomanganese reagents utilizing a cheap and easily available iron(III) precatalyst. The reactions exhibit a wide tolerance of solvents and functional groups, allowing for the conversion of thioesters derived from natural products and pharmaceutical compounds. A strong steric impact from each reaction component (carboxylic moiety, thiol substituent and manganese reagent) was displayed, which enabled regioselective transformation of dithioesters. Mechanistic investigations showed that the released thiolate does not act as a mere spectator ligand, but rather positively influences the stability of intermediate alkyl(II)ferrates.
Effect of gas properties and wall materials on particle charging in gas–solid fluidized beds
Authors: Hou Jiangtian , Liu Xiaoyu , Rahman M. Hafizur , Li Haisheng , Sundaresan Sankaran , Grace John R. , Bi Xiaotao 
Published: July 2022

AbstractThe charges acquired by polyethylene and glass particles fluidized by argon, nitrogen, and air at different humidity levels in acrylic and steel columns have been measured. Increased bed expansion at higher fluidization gas velocities lowered the space charge effect, allowing the particles to acquire more charges. The low dielectric strength of argon limits the extent of charging when the particles are fluidized in argon. The effect of the humidity of the air on particle charge differed appreciably between the two columns. The charge densities acquired by the particles in several experiments appear to have been limited by the dielectric strength of the fluidization gas.
Inductive effect of MXene membrane influenced by β‐cyclodextrin intercalation
Authors: Yang Haodong , Chen Huan , Chen Zhe , Li Yong , Yao Lei , Wang Geming , Deng Quanrong , Fu Ping 
Published: July 2022

AbstractTwo‐dimensional nanomaterials could be potentially applied in the field of brain–computer interface due to their significant inductive effect during ion permeation. In order to tune the inductive signal through the microstructure, a membrane based on MXene‐grafted β‐cyclodextrin (β‐CD) was prepared, and its electrochemical performance was recorded. The experimental results confirmed that β‐CD has been successfully intercalated into the gallery between the MXene sheets, and the intercalation induced a weaker inductive effect of MXene in the ion diffusion process. Moreover, the results indicated that easier ion diffusion through the membrane could result in weaker inductance. Besides, the experimental results were roughly analyzed by the back‐propagation (BP) neural network to compare the contribution of the influence factors. The results suggested that tunable inductance can be achieved by constructing a certain interlay spacing of MXene, which could be potentially used to design microsized inductors in biological applications.
Extremely Stable Sulfuric Acid Covalent Organic Framework for Highly Effective Ammonia Capture†
Authors: Li Jinli , Xiao Yun , Shui Feng , Yi Mao , Zhang Zhiyuan , Liu Xiongli , Zhang Laiyu , You Zifeng , Yang Rufeng , Yang Shiqi , Li Baiyan , Bu Xian‐He 
Published: July 2022

Comprehensive SummaryAmmonia (NH3) is one of the most important industrial feedstocks in the fields of fertilizers, drugs, explosives, ordnance, commercial cleanings, and so on. However, the features of ammonia such as high toxicity and corrosivity, and difficulty in handling would inevitably increase the risk of environmental damage and the deterioration of natural/public lands. Although sorts of solid adsorbents such as metal oxides, zeolites, organic polymers, activated carbons, and metal organic frameworks have been applied in NH3 capture, they still show low uptake capacity, low affinities, and instability. Herein, we developed the first case of a highly stable sulfuric acid covalent organic framework (COF), namely TpBD‐(SO3H)2, as NH3 capturer, in which sulfonic acid sites can strongly interact with NH3 molecules, and enhance the performance of NH3 sorption. As a result, TpBD‐(SO3H)2 shows high chemical stability under strong acid and water conditions, an important merit for the potential application in harsh environment. And it also exhibits high ammonia capacity of 11.5 mmol·g−1 at 298 K and 1.0 bar, making it one of the best in all chemically stable NH3 adsorbents up to date. This work thus develops sulfuric acid COF materials as a new platform for ammonia capture and storage.
Identity authentication for edge devices based on zero‐trust architecture
Authors: Liu Haiqing , Ai Ming , Huang Rong , Qiu Rixuan , Li Yuancheng 
Published: July 2022

SummaryDevice identity authentication is the first line of defense for edge computing security mechanisms. Many authentication schemes are often accompanied by high communication and computational overhead. In addition, due to the continuous enhancement of network virtualization and dynamics, the security requirements for logical boundaries of many enterprise information systems “cloudification,” and the huge data security challenges faced by enterprise core assets, all make the original "one‐time authentication, all the way" trust model no longer reliable. Therefore, the paper proposes a local identity authentication and roaming identity authentication protocol based on a zero‐trust architecture. First, we propose a revocable group signature scheme, the expiration time is bound to the key of each edge terminal device. According to this solution, since the identity authentication token generated by the expired key is invalid, it does not need to be included in the revocation list, which improves the efficiency of revocation checking. Compared with the current identity authentication protocol, this article not only builds a model based on the zero trust architecture, effectively solves the shortcomings of the network security protection architecture, but also considers the unforgeability of the expiration time, and realizes effective revocation and more efficient identity authentication.
Implementation of NUDT15 Genotyping to Prevent Azathioprine‐Induced Leukopenia for Patients With Autoimmune Disorders in Chinese Population
Authors: Wang Chuang‐Wei , Chi Min‐Hui , Tsai Tsen‐Fang , Yu Kuang‐Hui , Kao Hsiao‐Wen , Chen Hsiang‐Cheng , Chen Chun‐Bing , Lu Chun‐Wei , Chen Wei‐Ti , Chang Ya‐Ching , Chang Chih‐Jung , Chang Yun‐Ting , Jan Wu Yeong‐Jian , Chang Chee‐Jen , Huang Yu Huei , Ng Chau‐Yee , Huang Po‐Wei , Lin Yu‐Jr , Hui Rosaline Chung‐Yee , Chung Wen‐Hung ,   Taiwan/Asian Severe Cutaneous Adverse Reaction Consortium
Published: July 2022

Azathioprine (AZA) is commonly used for many autoimmune disorders; however, the limitation of its clinical use is due to potential toxicities, including severe leukopenia. Recent studies have identified genetic NUDT15 variants strongly associated with AZA‐induced leukopenia in Asian patients. This study aimed to investigate the strength of above genetic association and evaluate the usefulness of prospective screening of the NUDT15 variants to prevent AZA‐induced leukopenia in Chinese patients. AZA‐induced leukopenia in patients with autoimmune disorders were enrolled from multiple medical centers in Taiwan/China between 2012 and 2017 to determine the strength of genetic association of NUDT15 or TPMT variants by whole exome sequencing (WES). Furthermore, a prospective study was conducted between 2018 and 2021 to investigate the incidence of AZA‐induced leukopenia with and without genetic screening. The WES result showed the genetic variants of NUDT15 R139C (rs116855232) (P = 3.7 × 10−25, odds ratio (OR) = 21.7, 95% confidence interval (95% CI) = 12.1–38.8) and NUDT15 rs746071566 (P = 4.2 × 10−9, OR = 7.1, 95% CI = 3.7–13.7), but not TPMT, were associated with AZA‐induced leukopenia and NUDT15 R139C variant shows the highest sensitivity with 92.5%. Furthermore, the targeted screening of 1,013 participants for NUDT15 R139C enabled those identified as carriers to use alternative immunosuppressants. This strategy resulted in a significant decrease in the incidence of AZA‐induced leukopenia compared with historical incidence (incidence rate = from 7.6% decreased to 0.4%; P = 9.3 × 10−20). In conclusion, the NUDT15 R139C variant was strongly associated with AZA‐induced leukopenia in Chinese patients. The genetic screening of NUDT15 R139C followed by use of alternative immunosuppressants in identified carriers effectively decreased the incidence of AZA leukopenia for patients with autoimmune disorders.