bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cutaneous manifestations of autoinflammatory diseases
Authors: Wu Di , Shen Min , Yao Qingping 
Published: February 2022

Abstract
Autoinflammatory diseases (AIDs) are a heterogeneous group of disorders in which recurrent or continuous aseptic inflammation arises primarily through antigen-independent hyperactivation of the innate immune system. The skin is frequently involved with a wide variety of cutaneous manifestations, most of which are non-specific. Recognition of skin lesions in AIDs may sometimes provide clues for a correct diagnosis. In this review, the cutaneous involvements of >20 selected AIDs were summarized and organized into different categories based on their characteristic manifestations, such as urticarial dermatosis, neutrophilic dermatosis, granulomatosis, chilblain, lipodystrophy, and hyperkeratosis. With this classification scheme, cutaneous manifestations in AIDs could be more easily identified to facilitate diagnosis in clinical practice.
Macroglobulinemia and autoinflammatory disease
Authors: Navetta-Modrov Brianne , Yao Qingping 
Published: February 2022

Abstract
Macroglobulinemia is associated with Schnitzler syndrome (SchS) and Waldenstrom macroglobulinemia (WM). The aim of this article was to review the above-mentioned two diseases from clinical aspects and their potential genetic links. We performed a PubMed search using the following keywords: “SchS,” “WM,” “autoinflammatory disease,” “periodic fever syndrome,” and “nucleotide-binding oligomerization domain containing protein 2 (NOD2).” A case is exemplified. Both SchS and WM share some clinical phenotypes, and SchS can evolve into WM. Though no genetic link to SchS has been established, myeloid differentiation primary response gene 88 (MyD88) mutations are detected in one-third of SchS patients and 86% WM patients. Genetic analysis of periodic fever syndrome genes has detected NOD2 mutations in 18% SchS patients and rarely NLRP3 mutations. The literature data suggest that both MyD88 and NOD2 mutations may contribute to SchS. Both MyD88 and NOD2 are known to play important roles in innate immune response, and they may be cooperative in certain autoinflammatory diseases. Molecular analysis of NOD2 mutations may be incorporated into genetic testing for patients with suspected SchS or SchS/WM.
Tools to support infrastructure projects in the context of the global ﬁght against COVID-19 pandemic
Authors: Gorodetsky D. I. 
Published: February 2022

Introduction. The article is devoted to the study of mechanisms for supporting infrastructure projects in the context of the spread of the COVID-19 pandemic in the Russian Federation.Materials and methods. The research materials were normative acts, information and reference materials of ministries and departments, commercial organizations related to the implementation of state policy in the ﬁeld of development of infrastructure sectors of the economy and elimination of the consequences of the COVID-19 pandemic. Expert opinions, reports of rating agencies, publications in Russian and foreign publications were also used in the preparation of the article.The following research methods were used: statistical methods, methods of formal logic, description and interpretation, interpretation of normative acts. The study is based on the characteristics and analysis of the main points of the process of implementing state support for infrastructure projects.The results of the study. The implementation of infrastructure projects during the economic crisis, as long-term experience (since the 30s of the last century) shows, is one of the most important ways to reduce negative consequences due to the multiplicative effect generated during the implementation of these projects.The most vulnerable infrastructure sectors are transport, energy and social, while the municipal infrastructure suffers to a lesser extent. By the end of 2020, projects either under construction or commissioned, but signiﬁcantly dependent on consumer demand, suffered the most.The Russian Federation was among the few countries where signiﬁcant state support for the implementation of infrastructure projects was carried out in the context of the pandemic. At the same time, a fairly wide and ﬂexible toolkit was used: the provision of preferential targeted budget loans, the restructuring of previously issued budget loans on preferential terms, the ﬁnancing of projects at the expense of the proceeds from the placement of infrastructure bonds with state support.Discussion and conclusion. It should be noted that there is a certain sectoral limitation of support measures: for the most part, support measures are implemented in such areas as housing and communal services and transport infrastructure, partly in the fuel and energy sector.The regulatory provision of state support measures does not differ in consistency. In the guidance documents, it is impossible to single out projects developed directly during the pandemic with a certain accuracy. In addition, given the need for a prompt response to events related to the negative impact of the pandemic on infrastructure development, the absence of clearly deﬁned deadlines for the implementation of certain guidelines in regulatory documents is questionable.
Uji Aktivitas Antioksidan dan Formulasi Gel Ekstrak Etanol Daun Jeruk Nipis (Citrus aurantifolia)
Authors: Andika Bayu Tri , Rahmawati Dewi , Kuncoro Hadi 
Published: February 2022

Citrus aurantifolia leaves have several pharmacological properties such as antibacterial and antioxidant activity. The main objective of this study was to determine the antioxidant activity and obtain the best gel formula from the lime leaves ethanolic extracts. Five different concentrations of Citrus aurantifolia leaves extract namely FI, FII, FIII, FIV, and FV were tested for its antioxidant activity using the DPPH method. Furthermore, the lime leaves extract gel were formulated using carbopol 940. The gels were then evaluated for various parameters including organoleptic, homogeneity, pH, spreadability and viscosity to select best formulation. The extraction process was conducted using maceration method. The results of the DPPH radical scavenging activity showed that lime leaves extract with concentration 60,84 ppm has the preeminent IC50 value. The preparation of lime leaf ethanol extract gel obtained was clear white, clear green, green, brownish green, dark green, homogeneous, and had a characteristic smell of lime leaf. Evaluation of dispersion of 5-5.4 cm, pH of 5.1-5.8, and viscosity of 4.44-6.39 Pa.s. From the evaluation results, it can be concluded that formula 2 is the best formula.
Aktivitas Antioksidan Ekstrak Etanol Daun Kelapa Sawit (Elaeis guineensis Jacq.)
Authors: Zumaro Masrurotin , Rija’i Hifdzur Rashif , Narsa Angga Cipta , Sulistiarini Riski , Helmi Helmi 
Published: February 2022

Indonesia is a country with abundant natural wealth and almost all types of plants can grow in the territory of this country. One of them is oil palm leaf (Elaeis guineenis Jacq.) containing terpenoid compounds, steroids, alkaloids, flavonoids, glycosides, tannins and saponins and also this plant among the community has benefits that can be used for the treatment of skin infections. Purpose of this study was to determine the yield obtained as well as the antioxidant activity of ethanol extract of oil palm leaves. Oil palm leaves were extracted using 96% ethanol as solvents and using the maceration method. Testing the antioxidant activity of the ethanol extract of oil palm leaves was carried out using the DPPH method (2,2-diphenyl-1-picrylhydrazyl), where the absorbance was measured at max 515 nm using a UV-vis spectrophotometer. The results showed that the yield of oil palm leaf ethanol extract obtained as much as 5.44 % and obtained that the ethanolic extract of oil palm leaves had antioxidant activity against DPPH radicals with an IC50 value of 133.58 ppm. It could be concluded that the ethanolic extract of oil palm leaves (Elaeis guineensis Jacq.) had antioxidant activity in the moderate category because the IC50 value was between 100- 150 ppm.
Cuerpo (camino-aula) para comprender-resignificar la crisis del habitar desde la escucha de músicas populares
Authors: Ruiz Méndez José Leonardo , Chacón Ramírez Carlos Alberto 
Published: February 2022

Esta investigación es canto de cuerpo sintiente, manifestación de sentires presentes en la escucha de las músicas populares de los cuerpos-jóvenes-universitarios; exposición de una crisis del habitar que nos des-cubre en medio de la trama, en el aula de la vida.
Es construcción de una propuesta que, desde el sentir pretende des-cifrar la relación cotidiana entre cuerpo y habitar reivindicando la vida sensible como hecho fundante de ser humano. En este sentido comprende que, al construirse mundo simbólico desde las palabras y la relación con las cosas, se define lo estético y lo poético del habitar entramado en las urdimbres de la naturaleza ecosistémica, de la naturaleza cultural y de la naturaleza afectiva.
La escucha de las músicas populares revelada en forma de cuerpos embelesados, despechados y sometidos que cantan sin saberlo la crisis civilizatoria, devela la crisis profunda, la del sentir, la que pide dejar las cifras, los porcentajes, las estadísticas, para escuchar el cuerpo y así volver a la tierra natal. Cuerpo donde reside la crisis de la totalidad de los símbolos (Noguera, 2012, p. 10), crisis de una escucha que evidencia un habitar relacionado con las lógicas del capital, del desarrollo, del progreso.
Métodoestésis-Paidagoestésis, encuentro con el sentir como camino y aula de la vida.
Current state of prevalence and dynamics of alcohol-associated narcopathology: a retrospective study
Authors: Alekseenko S. N. , Gubarev S. V. , Lyubchenko D. A. , Redko A. N. 
Published: February 2022

Background. The population prevalence of alcohol abuse-associated drug-related diseases bears high social impact. This indicator holds special value both as a potential indirect estimator of the quality of life, availability and efﬁciency of drug addiction treatment, a well as parameter for qualitative prognostic models of social and economic development. The burden of alcohol-associated drug diseases is typically ambiguous in prevalence estimation, both across Russian Federation and worldwide.Objectives. A study of the alcohol abuse-associated drug-related morbidity prevalence in Krasnodar Krai for period 2000–2020.Methods. A retrospective descriptive study included legal-paper data of the “Information on Drug-Related Disorders” federal statistics survey (Form 11) of Krasnodar Krai, years 2000-2020, describing the re-registration rate of alcohol use-associated drug disorders. The inclusion criterion was an established drug-related disease among all age cohorts. The main study indicators were regional prevalence values of alcoholic psychosis, alcohol dependence syndrome and harmful alcohol use relative to gender, area and age.Results. Prevalence trends in alcohol use-related drug pathology were more favourable in Krasnodar Krai over Southern Federal District and country-wide. The decline rate among males was signiﬁcantly higher (22.1-fold) vs. the female population (3.0-fold). The prevalence of alcohol use-related drug pathology remained higher in urban vs. rural areas, with higher rural vs. urban decline rates. Over the entire study period, the 40–59 years-age population was leading by the incidence of overall alcohol use-related drug pathology and, separately, of alcoholic psychosis and alcohol dependence syndrome. Highest harmful alcohol use values were registered for 20–39-year population.Conclusion. The revealed dynamics of legal-registered alcoholic drug pathology prevalence has a multifactorial origin. The changes are conditioned by improvement in the narcological aid institutional regulation within the state guarantee programme, federal and regional preventive measures, current progress in drug therapy, regional demography, as well as underreporting of alcohol-associated drug diseases due to a missing strict vertical statistic registration at the level of any-type medical institutions.
Impact of bispectral index monitoring on critical incidents rate in high-risk patients: a randomised controlled trial
Authors: Trembach N. V. 
Published: February 2022

Background. The likelihood of intraoperative critical incidents depends largely on reﬂex control of the cardiorespiratory system that is often susceptible to chronic pathology. The reﬂex suppression may link to the depth of anaesthesia, making the latter monitoring particularly important at higher hypotension risks and their patient predisposition.Objectives. A study of the effect of bispectral index anaesthesia monitoring on critical incidents (CIs) rate in high-risk abdominal surgery patients.Methods. A randomised controlled trial enrolled 80 high-risk and 80 low-risk patients. Each cohort randomly allocated patients between subcohorts (by 40 people): 1 — anaesthesia rendered to maintain a 40–60 bispectral index (treatment cohort), 2 — by clinical values and anaesthetic level control in exhaled gas (control cohort), intraoperative control of anaesthetic requirement, bispectral index and critical incidents.Results. A critical incidents rate analysis in high-risk patients showed a lower rate in the bispectral index anaesthesia control cohort. Total 127 critical incidents were registered in 53 patients. The analysis revealed fewer CIs for objective sedation depth monitoring, 45% patients of treatment cohort vs. 87.5% in control. Signiﬁcantly fewer (by half) patients exhibited hypotension in the treatment cohort, with lower (4-fold) rates of arrhythmia, bradycardia and general respiratory CIs. Anaesthetic doses and bispectral indices at anaesthesia stages were signiﬁcantly lower in the treatment cohort as well.Conclusion. Objective anaesthesia depth monitoring in high-risk patients reduces the rates of haemodynamic incidents during anaesthesia maintenance and respiratory incidents at arousal due to prevention of excessive anaesthetic depth.
Digital Rock Reconstruction Using Wasserstein GANs with Gradient Penalty
Authors: Li Yiteng , He Xupeng , Zhu Weiwei , AlSinan Marwa , Kwak Hyung , Hoteit Hussein 
Published: February 2022

Abstract
Due to the scarcity and vulnerability of physical rock samples, digital rock reconstruction plays an important role in the numerical study of reservoir rock properties and fluid flow behaviors. With the rapid development of deep learning technologies, generative adversarial networks (GANs) have become a promising alternative to reconstruct complex pore structures. Numerous GAN models have been applied in this field, but many of them suffer the unstable training issue. In this study, we apply the Wasserstin GAN with gradient penalty, also known as the WGAN-GP network, to reconstruct Berea sandstone and Ketton limestone. Unlike many other GANs using the Jesnen-Shannon divergence, the WGAN-GP network exhibits a stable training performance by using the Wasserstin distance to measure the difference between generated and real data distributions. Moreover, the generated image quality correlates with the discriminator loss. This provides us an indicator of the training state instead of frequently subjective assessments in the training of deep convolutional GAN (DCGAN) based models. An integrated framework is presented to automate the entire workflow, including training set generation, network setup, model training and synthetic rock validation. Numerical results show that the WGAN-GP network accurately reconstructs both Berea sandstone and Ketton limestone in terms of two-point correlation and morphological properties.
Quantitatively Evaluating Far-Field Fractures by Analyzing Azimuthal Acoustic Waveforms: Case Studies in Vertical and Horizontal Wells
Authors: Chen Yanyan , Rui Yun , Huang Zheyuan , Li Junjun , Wang Yue , Liu Fei , Bennett Nicholas , Mo Jing 
Published: February 2022

Abstract
To understand formation structures extending away from the wellbore, azimuthal acoustic waveforms are acquired with longer recording length compared to conventional sonic logging. Advanced acoustic waveform processing algorithms such as 3D slowness time coherence (3D STC) and ray tracing applied to the reflection waveforms allow for quantitatively determining the true dip, azimuth, and position of the reflectors in 3D space, especially for far-field reflectors that can't be detected or located by conventional logging methods.
In this paper we discuss two case studies of fracture evaluation. For the first one, experiences indicated that natural fractures bring operation risk for horizontal wells in shale gas play of Middle Yangtze Basin, such as casing deformation or screenout. Therefore, it was of great importance to evaluate natural fractures before completion and fracturing design. The borehole resistivity image log provided fracture assessment at the wellbore but cannot assess far-field fractures. The surface seismic ant track depicted fracture distribution on a large scale, yet with limited resolution. Azimuthal borehole acoustic reflection imaging filled the gap in between by identifying fractures as far as tens of meters from the wellbore. In the cased-hole horizontal well, the natural fracture results from azimuthal borehole acoustic reflection imaging confirmed the mud losses encountered while drilling. The operator used the results to optimize the completion design by placing perforation cluster about 15 m away from the natural fractures, and to change the fracturing design by adjusting slurry rate and fluid volume accordingly.
For the second case, azimuthal borehole acoustic waveforms were acquired twice with the first run along an interval of Longmaxi shale gas in the vertical section of a 12.25-in. hole and the second run in a deviated section of an 8.5-in. hole. The result of the first run revealed a layer boundary between shale and carbonate. For the second run, high-dip-angle fractures in carbonate formations were identified with a maximum distance of 32 m from the wellbore. The dip and azimuth agreed with the few conductive fractures identified by the borehole resistivity image, yet the former identified more fractures than the latter.
The two case studies clearly illustrate that azimuthal borehole acoustic imaging can quantitatively evaluate far-field fractures away from the wellbore, e.g., the true dip and azimuth, as well as position in 3D space. This helps not only provide a better reservoir characterization, but also allows optimization of the completion and fracturing design.
Geochemical and Petrographic Characteristics of Lithofacies from Upper Cretaceous Organic-Rich Source Rocks, Jordan
Authors: Abu-Mahfouz Israa S. , Ardila Maria , Vahrenkamp Volker 
Published: February 2022

Abstract
The Upper Cretaceous source rocks of Jordan are organic-rich carbonate mudrocks that represent excellent source rocks but are essentially still immature to just entering the oil window. Therefore, they offer a unique opportunity to study lithology, source rock composition, and geochemistry prior to the onset of maturation and expulsion of hydrocarbons. Our study aims to examine the lithological and geochemical characteristics of these high-quality source rocks. The study utilizes an integrated petrographic and geochemical approach to define the different microfacies in the studied source rock sequence and understand their intrinsic variability. Representative subsurface samples were collected from 13 vertical cores drilled in the Upper Cretaceous interval across Jordan for bulk elemental geochemistry and microfacies analysis. To define the different microfacies and examine the mineralogical and geochemical changes, the samples were investigated for their composition, texture and lithofacies (using both optical microscopy and scanning electron microscopy (SEM/EDS)), mineralogy (XRD/XRF), and geochemistry (total organic carbon, (TOC) and total Sulphur content using a LECO elemental analyzer, and maturity using Rock-Eval).
Five laminated and non-laminated carbonate and siliceous lithofacies associations were identified, all containing significant organic content (TOC varies from 7 to 29 wt.%) and Sulphur contents (2-7.5 wt.%). The rocks are of type II-S kerogen with high HI (Hydrogen Index) values of &gt;600 mg HC/g TOC. XRD results show that the rocks are mainly composed of calcite (15-94%, 75% on average) and quartz (0-53%, 10.47% on average). Minor amounts of apatite (average 5.9%, range 0 to 27%), clay (&lt; 7%), pyrite (up to 6%), gypsum (up to 4%) and dolomite (up to 2.7%) are also exist. Our results indicate a predominance of the organic-rich calcareous microfacies association, evidenced by the abundant foraminifera grains and the high preservation of organic matter as disseminated throughout the matrix and/or filling interparticle micropores and microfractures. This reflects the deposition in a restricted basin under anoxic conditions.
The integration of the data obtained through the different techniques used in this study together with the unique characteristics of these source rocks allowed the characterization of the geological and geochemical properties of the defined lithofacies associations in these immature, organic-rich Upper Cretaceous source rocks. This, in turn, helped to achieve a better evaluation of the occurrence and distribution of the different litho- and organic facies and estimation of hydrocarbon source potential.
Regional Mapping and Characterization of Upper Albian Shelf Reservoir Using Data Integration at Deepwater Gambia
Authors: Hasnan Hasnor Farhana , Kurniawan Trisakti , Ibrahim Chyril Anwwar 
Published: February 2022

Abstract
The upper Albian shelf reservoir at deepwater Gambia is modelled as deltaic and basin floor fan plays, identified based on seismic and well data characterization as well as sequence stratigraphy. There are recently proven Albian shelf reservoirs in the neighboring Senegal waters, the SNE field, which become the motivation for exploring the deepwater Gambia, and to spud the first well for offshore The Gambia in 40 years.
Recent discovery wells in the deepwater MSGBC basin have shown that the main geological risk in finding prospective leads in this region will depend on the understanding of reservoir presence and the distribution of reservoir effectiveness, where these are mainly influenced by the presence of quartz and calcite and their cementation rate.
This paper describes the effort in integrating geological information as a basis to develop the best geophysical approach as part of a derisking tool for exploration lead and prospect screening. The main objective is to develop a predictive tool which combines the benefit of understanding the rock properties under these geological circumstances with the elastic properties as a representative seismic response to enhance the reliability of the model in predicting reservoir effectiveness distribution. This analysis allows us to effectively reduce the uncertainty in the prediction of low contrast reservoir from the seismic data.