bluuebunny/crossref_metadata_2025_split huggingface dataset:
Longitudinal Associations between Inflammatory Markers and Fatigue up to Two Years after Colorectal Cancer Treatment
Authors: Querido Nadira R. , Kenkhuis Marlou-Floor , van Roekel Eline H. , Breukink Stéphanie O. , van Duijnhoven Fränzel J.B. , Janssen-Heijnen Maryska L.G. , Keulen Eric T.P. , Ueland Per Magne , Vogelaar F. Jeroen , Wesselink Evertine , Bours Martijn J.L. , Weijenberg Matty P. 
Published: June 2022

Abstract

Background:
Fatigue is often reported by colorectal cancer survivors and largely impacts their quality of life. Inflammation has been linked to fatigue mainly in patients with breast cancer. Therefore, we investigated how inflammation is longitudinally associated with fatigue in colorectal cancer survivors, up to 2 years posttreatment.

Methods:
A total of 257 patients from the ongoing Energy for life after ColoRectal cancer cohort study were included in the analysis. Plasma levels of IL6, IL8, IL10, TNFα, high-sensitivity C-reactive protein (hsCRP), and fatigue were measured at 6 weeks, 6, 12, and 24 months posttreatment. Fatigue was measured through the validated Checklist Individual Strength (CIS; total, 20–140), consisting of four subscales – subjective fatigue (8–56), motivation (4–28), physical activity (3–21), and concentration (5–35), and the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Core 30 fatigue subscale (0–100). Linear mixed-models were used to assess the confounder-adjusted longitudinal associations between inflammatory markers and overall fatigue along with the subscales.

Results:
Mean levels of CIS fatigue decreased from 62.9 at 6 weeks to 53.0 at 24 months. In general, levels of inflammatory markers also decreased over time. No statistically significant longitudinal associations were found between IL6, IL8, IL10, TNFα, and fatigue. Higher levels of hsCRP were associated with more CIS fatigue (β per SD 3.21, 95% confidence interval (CI), 1.42–5.01) and EORTC fatigue (β 2.41, 95% CI, 0.72–4.10).

Conclusions:
Increased levels of hsCRP are longitudinally associated with more posttreatment fatigue in colorectal cancer survivors.

Impact:
These findings suggest that low-grade inflammation may play a role in fatigue reported by colorectal cancer survivors up to 2 years posttreatment.
On the occurrence of Scinax kennedyi (Pyburn, 1973) (Anura, Hylidae) in the state of Roraima, northern Brazil
Authors: Lopes André Gomes , Giaretta Ariovaldo Antonio 
Published: June 2022

Scinax comprises 129 species of treefrogs divided between the S. ruber and the S. catharinae clades. The S. rostratus group belongs to the S. ruber clade, and comprises ten species characterized by having a dark interorbital triangular mark, tubercle on the heel and by vocalizing in a head-down position. Within this group, S. kennedyi and S. rostratus are similar in that they are the only species that do not possess a row of tubercles on the lower jaw. In spite of their morphological similarity, they can be distinguished from each other by male size and advertisement call traits. Scinax kennedyi was described from eastern Colombia, and occurs from central Colombia to western Venezuela, whereas S. rostratus was described from northern Venezuela, and is thought to occur from Panama to eastern Venezuela, and in the Brazilian state of Pará. A recent study reported a population identified as S. rostratus from the state of Roraima, in northern Brazil. However, this population presented substantial differences in male size and advertisement call in comparison to the described for this species, and apparently it best fits the diagnosis of S. kennedyi instead. In view of this, the present study aimed to clarify the identity of this Brazilian population through a reassessment of its specimens and call recordings, together with the examination of data of S. kennedyi from its type locality, and of S. rostratus from northern Venezuela. Acoustic and morphological analyses revealed that specimens from northern Brazil were indeed misidentified as S. rostratus, and hence they were herein reassigned to S. kennedyi. The study therefore demonstrates the occurrence of S. kennedyi in Brazil, extending its distribution ca. 1,120 km east by south from its type locality, and ca. 844 km east-southeast from its easternmost previous record. With this reassessment, a clearer acoustic diagnosis between S. kennedyi and S. rostratus was provided, as well as further data on fine-scale temporal traits of their calls.
pH-Dependent Protonation of Histidine Residues Is Critical for Electrostatic Binding of Low-Density Lipoproteins to Human Coronary Arteries
Authors: Glise Lars , Rutberg Mikael , Håversen Liliana , Levin Malin C. , Levin Max , Jeppsson Anders , Borén Jan , Fogelstrand Per 
Published: June 2022

Background:
The initiating step in atherogenesis is the electrostatic binding of LDL (low-density lipoprotein) to proteoglycan glycosaminoglycans in the arterial intima. However, although proteoglycans are widespread throughout the intima of most coronary artery segments, LDL is not evenly distributed, indicating that LDL retention is not merely dependent on the presence of proteoglycans. We aim to identify factors that promote the interaction between LDL and the vessel wall of human coronary arteries.

Methods:
We developed an ex vivo model to investigate binding of labeled human LDL to human coronary artery sections without the interference of cellular processes.

Results:
By staining consecutive sections of human coronary arteries, we found strong staining of sulfated glycosaminoglycans throughout the arterial intima, whereas endogenous LDL deposits were focally distributed. Ex vivo binding of LDL was uniform at all intimal areas with sulfated glycosaminoglycans. However, lowering the pH from 7.4 to 6.5 triggered a 35-fold increase in LDL binding. The pH-dependent binding was abolished by pretreating LDL with diethyl-pyrocarbonate, which blocks the protonation of histidine residues, or cyclohexanedione, which inhibits the positive charge of site B on LDL. Thus, both histidine protonation and site B are required for strong electrostatic LDL binding to the intima.

Conclusions:
This study identifies histidine protonation as an important component for electrostatic LDL binding to human coronary arteries. Our findings show that the local pH will have a profound impact on LDL’s affinity for sulfated glycosaminoglycans, which may influence the retention and accumulation pattern of LDL in the arterial vasculature.
A single-centre experience of His bundle pacing without electrophysiological mapping system: implant success rate, safety, pacing characteristics and one-year follow up
Authors: Kui Swee Leng , Yeo Colin , Teo Lisa , Him Ai Ling , Syed Hamid Sherida Binte , Wong Kelvin , Tan Vern Hsen 
Published: June 2022

Introduction:
Despite the challenges related to His bundle pacing (HBP), recent data suggest an improved success rate with experience. As a non-university, non-electrophysiology specialised centre in Singapore, we report our experiences in HBP using pacing system analyser alone.

Methods:
Data of 28 consecutive patients who underwent HBP from August 2018 to February 2019 was retrospectively obtained. The clinical and technical outcomes of these patients were compared between two timeframes of three months each. Patients were followed up for 12 months.

Results:
Immediate technical success was achieved in 21 (75.0%) patients (mean age 73.3 ± 10.7 years, 47.6% female). The mean left ventricular ejection fraction was 53.9% ± 12.1%. The indications for HBP were atrioventricular block (n = 13, 61.9%), sinus node dysfunction (n = 7, 33.3%) and upgrade from implantable cardioverter-defibrillator to His-cardiac resynchronisation therapy (n = 1, 4.8%). No significant difference was observed in baseline characteristics between Timeframe 1 and Timeframe 2. Improvements pertaining to mean fluoroscopy time were achieved between the two timeframes. There was one HBP-related complication of lead displacement during Timeframe 1. All patients with successful HBP achieved non-selective His bundle (NSHB) capture, whereas only eight patients had selective His bundle (SHB) capture. NSHB and SHB capture thresholds remained stable at the 12-month follow-up.

Conclusion:
Permanent HBP is feasible and safe, even without the use of an electrophysiology recording system. This was successfully achieved in 75% of patients, with no adverse clinical outcomes during the follow-up period.
A New Method for Thermocline and Halocline Depth Determination at Shallow Seas
Authors: Janecki Maciej , Dybowski Dawid , Rak Daniel , Dzierzbicka-Glowacka Lidia 
Published: June 2022

Abstract
This paper introduces a new method for finding the top of thermocline (TTD) and halocline (THD) depths that may become a powerful tool for applications in shallow marine basins around the world. The method calculates the moving average of the ocean vertical profile’s short-scale spatial variability (standard deviation) and then processes it to determine the potential depth at which temperature or salinity rapidly changes. The method has been calibrated using an extensive set of data from the ecohydrodynamic model EcoFish. As a result of the calibration, the values of the input parameters that allowed the correct determination of TTD and THD were established. It was confirmed by the validation carried out on the in situ profiles collected by the research vessel S/Y Oceania during statutory cruises in the southern Baltic Sea. The “MovSTD” algorithm was then used to analyze the seasonal variability of the vertical structure of the waters in Gdańsk Deep for temperature and salinity. The thermocline deepening speed was also estimated in the region analyzed.
Smallholder Knowledge of Local Climate Conditions Predicts Positive On-Farm Outcomes
Authors: Salerno Jonathan , Bailey Karen , Diem Jeremy , Konecky Bronwen , Bridges Ryan , Namusisi Shamilah , Bitariho Robert , Palace Michael , Hartter Joel 
Published: June 2022

Abstract
People’s observations of climate change and its impacts, mediated by cultures and capacities, shape adaptive responses. Adaptation is critical in regions of rainfed smallholder agriculture where changing rainfall patterns have disproportionate impacts on livelihoods, yet scientific climate data to inform responses are often sparse. Despite calls for better integration of local knowledge into adaptation frameworks, there is a lack of empirical evidence linking both smallholder climate observations and scientific data to on-farm outcomes. We combine smallholder observations of past seasonal rainfall timing with satellite-based rainfall estimates in Uganda to explore whether farmers’ ability to track climate patterns is associated with higher crop yields. We show that high-fidelity tracking, or alignment of farmer recall with recent rainfall patterns, predicts higher yields in the present year, suggesting that farmers may translate their cumulative record of environmental knowledge into productive on-farm decisions, such as crop selection and timing of planting. However, tracking of less-recent rainfall (i.e., 1–2 decades in the past) does not predict higher yields in the present, while climate data indicate significant trends over this period toward warmer and wetter seasons. Our findings demonstrate the value of smallholder knowledge systems in filling information gaps in climate science while suggesting ways to improve adaptive capacity to climate change.
Broadcast Meteorologists and Personal Branding: An Exploratory Study after a Hurricane Crisis
Authors: Zavattaro Staci M. , Stevens Kelly A. 
Published: June 2022

Abstract
Television station and on-air talent marketing and branding has been studied with increasing attention because there is recognition that the people are part of an overall brand strategy. In this paper, we focus on broadcast meteorologists and their views of their personal brands and how those work to engage audiences. With Hurricane Dorian in 2019 as the background major weather event, the paper focuses on how on-air meteorologists develop their brand identities. From these interviews, we find 1) personal branding to build trust is paramount, 2) social media are game changers for personal branding, and 3) station branding can influence personal branding. Our findings shed light on the tension some on-air meteorologists experience when seeing themselves as a commodity while also trying to build trust as an expert crisis communicator.

Significance Statement
The purpose of our study is to examine how on-air meteorologists understand the role that personal branding plays—if any at all—in helping them deliver information to viewers. In previous research, Daniels and Loggins noted that, as the landscape for communicating lifesaving information changes, understanding how on-air meteorologists understand their roles and personal identities becomes paramount. If weather is a product, the people delivering the information become part of the product and overall brand strategy, according to Daniels and Loggins. Our exploratory study indicates that personal branding poses some opportunities and challenges for on-air meteorologists, who sometimes see an internal conflict between station branding strategies and their roles as scientists.
Silent Indigenous Revolution in Ecuador and Mariátegui’s Thought
Authors: Jassir Mauricio Jaramillo 
Published: June 2022

Examination of the silent and generally unnoticed cooperation of Ecuador’s indigenous peoples with the fragmented left in the light of José Carlos Mariátegui’s theses shows that, despite the two’s having separate projects, this cooperation contributed to transformations that the indigenous movement had pursued for decades. This underlines Mariátegui’s call for relating Marxism to the complex indigenous reality and avoiding the extrapolation of European communism to the Andean situation. Un análisis de la cooperación silenciosa y generalmente inadvertida de los pueblos indígenas de Ecuador con la izquierda fragmentada a partir de una aproximación basada en las tesis de José Carlos Mariátegui muestra que, a pesar de que cada grupo tenía proyectos separados, dicha cooperación contribuyó a las transformaciones que el movimiento indígena había perseguido durante décadas. Esto subraya el llamado de Mariátegui a relacionar el marxismo con la compleja realidad indígena y a evitar la extrapolación del comunismo europeo a la situación andina.
Targeting EGFR Exon 20 Insertion Mutation in Non–small cell Lung Cancer: Amivantamab and Mobocertinib
Authors: Russell Molly C. , Garelli Alyssa M. , Reeves David J. 
Published: June 2022

Objective To evaluate clinical data regarding the use of amivantamab and mobocertinib for epidermal growth factor receptor (EGFR) exon 20 insertion mutation non–small cell lung cancer (NSCLC) and assess their potential impact on the care of patients. Data Sources A comprehensive literature search of PubMed and Clinicaltrials.gov was conducted using the terms amivantamab, Rybrevant, JNJ-61186372, mobocertinib, Exkivity, TAK-788. Study Selection and Data Extraction Relevant English-language clinical trials were evaluated. Data Synthesis Amivantamab and mobocertinib were Food and Drug Administration (FDA) approved based on phases 1 and 2 studies. Amivantamab demonstrated an overall response rate (ORR) of 40% and median progression-free survival (PFS) of 8.3 months. Patients commonly experienced rash (86%), paronychia (45%), and stomatitis (21%). Mobocertinib demonstrated an ORR of 28% and median PFS of 7.3 months in phase 1/2 study. Patients frequently experienced diarrhea (91%), rash (45%), and paronychia (38%). Cardiac monitoring is recommended with mobocertinib due to risk of QTc prolongation and cardiac failure. Relevance to Patient Care For NSCLC patients who possess an EGFR exon 20 insertion mutation, amivantamab and mobocertinib are indicated as second-line therapy. Ongoing studies are evaluating these therapies as first-line monotherapy and as part of combination regimens in multiple cancer types. Dosage forms, drug interactions, and patient comorbidities should be considered when deciding which of the 2 agents may be most appropriate. Conclusion Amivantamab and mobocertinib target an uncommon NSCLC mutation that has historically marked a poor prognosis because of innate resistance to previously approved EGFR tyrosine kinase inhibitors. Promising results from early phase trials supported accelerated FDA approval.
Epithelial downgrowth leading to graft rejection after penetrating keratoplasty
Authors: Godin Fernando , Mercado Carolina , Larco Pablo , Pacheco L Maria A , Borroni Davide , Chacon Aponte Alberto 
Published: June 2022

Purpose To report a case of epithelial downgrowth after penetrating keratoplasty. Case description A 58-year-old man presented with graft rejection in his three-month-old, repeat penetrating keratoplasty. Examination revealed centripetal opacification of the posterior cornea due to deep epithelization. He had new retro-corneal membranes and anterior uveitis. Specular microscopy and anterior segment optical coherence tomography were performed, and a clinical diagnosis of epithelial downgrowth was made. The patient had intracameral injections with 5-fluorouracil (5FU) and achieved resolution of intraocular findings after treatment. Conclusions Epithelial downgrowth is an uncommon complication of penetrating keratoplasty. It affects the patients’ visual acuity and graft survival. Clinical observation is preferred in severe cases due to the high risk of intraocular damage; intracameral 5FU promises to be a good option in these cases.
Prospective relationship between autistic traits and nutrient intakes among Japanese children: Results of the Shika study
Authors: Tsujiguchi Hiromasa , Hara Akinori , Miyagi Sakae , Pham Kim Oanh , Suzuki Keita , Nguyen Thao Thi Thu , Ono Yasuki , Kambayashi Yasuhiro , Shimizu Yukari , Nakamura Haruki , Suzuki Fumihiko , Shibata Aki , Hayashi Koichi , Tsuboi Hirohito , Nakamura Hiroyuki 
Published: June 2022

Increased food selectivity among children with autism spectrum disorder may lead to nutritional inadequacy. We designed this study to examine the prospective relationship between autistic traits in children and subsequent nutrient intake in later childhood and whether this relationship changes over time. We utilized longitudinal data obtained at two time points from the Shika study, an ongoing population-based study conducted in a rural area of Japan. Participants were 759 Japanese children aged between 7 and 12 years at baseline and between 10 and 15 years in the follow-up. The results obtained showed relatively lower intakes of sodium, calcium, magnesium, iron, vitamin D, vitamin B2, and vitamin B12 among children with than without autistic traits. Interactions were observed among autistic traits and time points for iron, vitamin B2, folic acid, and pantothenic acid. The results of this study suggest the importance of screening the nutrient intake of children with autistic traits across childhood in order to reduce the risk of restricted intake. Lay Abstract It is known about food selectivity among children with autism spectrum disorder. However, the nutritional inadequacy among children with ASD is not clear. Especially, long-term evaluation has not been studied. We examined the prospective relationship between autistic traits in children and subsequent nutrient intake in later childhood. We utilized data obtained at two time points from a study conducted in Japan. Participants were 759 Japanese children aged between 7 and 12 years at baseline and between 10 and 15 years in the follow-up. The results showed relatively lower intakes of sodium, calcium, magnesium, iron, vitamin D, vitamin B2, and vitamin B12 among children with than without autistic traits. Relatively lower intake of minerals and vitamins in children with autistic traits is more evident in later childhood. The results suggest the importance of screening the nutrient intake of children with autistic traits across childhood.
Transcriptome Profiling Unveils a Critical Role of IL-17 Signaling-Mediated Inflammation in Radiation-Induced Esophageal Injury in Rats
Authors: Yao Jia , Zhang Jinkang , Wang Jinlong , Lai Qian , Yuan Weijun , Liu Zhongyu , Cheng Shuanghua , Feng Yahui , Jiang Zhiqiang , Shi Yuhong , Jiang Sheng , Tu Wenling 
Published: June 2022

Elucidation of the molecular mechanisms involving the initiation and progression of radiation-induced esophageal injury (RIEI) is important for prevention and treatment. Despite ongoing advances, the underlying mechanisms controlling RIEI remain largely unknown. In the present study, RNA-seq was performed to characterize mRNA profiles of the irradiated rat esophagus exposed to 0, 25, or 35 Gy irradiation. Bioinformatics analyses including dose-dependent differentially expressed genes (DEGs), Gene Ontology (GO), Kyoto Encyclopedia of Gene and Genome (KEGG) pathway, protein-protein interaction (PPI) network, and immune infiltration were performed. 134 DEGs were screened out with a dose-dependent manner (35 Gy > 25 Gy > control, or 35 Gy < 25 Gy < control). GO and KEGG analyses showed that the most significant mechanism was IL-17 signaling-mediated inflammatory response. 5 hub genes, Ccl11, Cxcl3, Il17a, S100a8, and S100a9, were identified through the intersection of the DEGs involved in inflammatory response, IL-17 pathway, and PPI network. Additionally, immune infiltration analysis showed the activation of macrophages, monocytes, T cells, NKT cells, and neutrophils, among which macrophages, monocytes, and neutrophils might be the main sources of S100a8 and S100a9. Thus, these findings further our understanding on the molecular biology of RIEI and may help develop more effective therapeutic strategies.
Neutropenia, neutrophilia, and neutrophil–lymphocyte ratio as prognostic markers in patients with metastatic castration-resistant prostate cancer
Authors: Meisel Alexander , de Wit Ronald , Oudard Stephane , Sartor Oliver , Stenner-Liewen Frank , Shun Zhenming , Foster Meredith , Ozatilgan Ayse , Eisenberger Mario , de Bono Johann S. 
Published: June 2022

Background and purpose: Chemotherapy-induced neutropenia and neutrophil-to-lymphocyte ratio (NLR) are potentially useful prognostic markers in patients with metastatic castration-resistant prostate cancer (mCRPC). This post hoc analysis investigated whether these markers can be utilized for dose considerations and evaluated the prognostic impact of leukocyte subtypes. Patients and methods: PROSELICA assessed the non-inferiority of cabazitaxel 20 mg/m2 (C20; n = 598) versus 25 mg/m2 (C25; n = 602) for overall survival (OS) in patients with mCRPC previously treated with docetaxel. The association of grade ⩾ 3 neutropenia, NLR, baseline neutrophilia and lymphopenia with OS, progression-free survival (PFS), and prostate-specific antigen response rate (PSArr) was investigated by an unplanned uni- and multivariate analyses. Results: PROSELICA confirmed the negative prognostic value of increased baseline NLR [⩾3, hazard ratio (HR) 1.40; p < 0.0001], but did not identify a subgroup of patients benefiting more from C20 or C25. In this post hoc analysis, patients who developed grade ⩾3 neutropenia ( n = 673) had a significantly improved OS [∆OS = 2.7 months, HR = 0.78 (95% CI 0.68–0.89)] with the greatest advantage observed in patients with baseline neutrophilia [ n = 85; 5.3 months, 0.60 (0.42–0.84)]. After adjustment for the Halabi criteria, neutropenia grade ⩾ 3 was the only biomarker that remained significantly associated with OS [ (HR 0.86 (0.75–0.98)], PFS [HR 0.78 (0.68–0.88)], and PSArr [odds ratio (OR) 1.82 (1.37–2.41)] while neutrophilia showed the strongest association with OS [1.53 (1.29–1.81)]. Conclusions: Grade ⩾ 3 neutropenia was the only leukocyte-based biomarker associated with all key outcome parameters in mCRPC patients receiving cabazitaxel and might be able to overcome the negative prognostic effect of baseline neutrophilia. NCT number: NCT01308580