bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical experience of surgical repair left ventricular rupture after mitral valve replacement
Authors: Dung Van Hung 
Published: April 2022

Background: Left ventricular rupture after mitral valve replacement is very rare but often leads to death. This study aimed to report one center experience.
Methods: Retrospective case series from 2001 to 2021 at the Heart Institute.
Results: There had 18 cases of left ventricular rupture after mitral valve replacement (0.2%). 94% of patients were female, the mean age at surgery was 57. Rheumatic mitral stenosis (11) or mitral disease (6) occurred in the majority of cases. 6/18 has posterior annulus calcification; 3/18 cases had reoperation after previous mitral valve replacement. The median valve size was 27 (25-29mm). Type I rupture 03; type II: 1 and type III: 14. Time of left ventricular rupture occurrence: early in 5; late in 2 and intermediate in 11 cases. The mortality rate was 61% (11/18). Regarding the repair technique, 8 cases of external repairs, without opening the heart and 10 cases of combined internal and external repairs, reinforced with bio-glue. 100% had supported by extracorporeal circulation and 15/18 cases had inserted intra-aortic balloon counterpulsation.
Conclusion: preserve the posterior valve as much as possible, gentle resection of the diseased valve, and no need for radical decalcification of the posterior annulus are measures to prevent left ventricular rupture. The combined technique of internal and external repairs with bio-glue coating has shown a good hemostatic and high success rate.
Imaging characteristics, and long term outcomes of surgical management for pannus overgrowth after mechanical aortic valve replacement
Authors: Dung Van Hung 
Published: April 2022

Background: Endocardial proliferation or pannus is uncommon after aortic valve replacement. This study aimed to determine the imaging characteristics, the risk factors and evaluate the long-term results of surgical treatment for these patients.
Material and methods: a retrospective review of patients with confirmed intraoperative pannus diagnosis following mechanical aortic replacement.
Results: There have 102 patients (mean age 48 and 71 women) who were re-operated for pannus. The image of “pannus” seen on echocardiography and valve dysfunction on fluoroscopy is positive in over 90% of cases. Female sex (OR=2.1, P=0.01) and both aortic and mitral valve replacement at first surgery (OR=2.98; P = 0.001) have a higher risk of pannus. Surgical procedures included pannus resection only or aortic replacement with a new valve and resect pannus or resect pannus, aortic replacement with aortic annulus enlargement. 30-day mortality was 1 case; atrioventricular block required permanent pace marker: 2 cases. The mean follow-up time for the second operation was 55.3 ± 48.8 months (2 cases lost of follow-up), recurrent pannus occurred in 5 cases, and no late death.
Conclusion: The female patients and previously aortic combined with mitral replacement are a risks factor for pannus. Echocardiography combined with fluoroscopy could be identified as the diagnosis of pannus. The long-term outcomes of surgery for pannus are very good. Completely resect the pannus and replace it with the new valve is the method of choice instead of simply resecting the pannus to prevent recurrent pannus.
Rezension von: Jäger, Sven, Germanische Siedlungsspuren des 3. bis 5. Jahrhunderts n. Chr. zwischen Rhein, Neckar und Enz
Authors: Setzler Wilfried , Jäger Sven 
Published: April 2022

Sven Jäger: Germanische Siedlungsspuren des 3. bis 5. Jahrhunderts n. Chr. zwischen Rhein, Neckar und Enz. (Forschungen und Berichte zur Archäologie in Baden-Württemberg, Band 14). Dr. Ludwig Reichert Verlag Wiesbaden 2019. 926 Seiten mit 270 farbigen und 60 s/w Abbildungen, 82 Tafeln und 44 Plananhängen, 3 Beilagen. Gebunden € 120,–. ISBN 978-3-95490-444-0
Critical factors that affecting adoption of e-learning based on cloud computing for Iraqi higher education organizations
Authors: Abdulsaeed Ali A. , Burhanuddin M A , Ghani Mohd Khanapi Abd , Jaber Mustafa Musa 
Published: April 2022

Cloud computing-based e-learning is one of the most popular techniques discovered to promote traditional instruction by software applications and a virtual learning environment. There are many factors that could be regarded in a company's effort to implement or embrace new technology initiatives. As in the literature, many scientists and researchers have particularly explored the factors that influence the adoption of cloud computing along with e-learning issues based on cloud computing that are derived from standards models such as Technology-Organization-Environment (TOE) framework and Technology Acceptance Model (TAM). The aim of the study is to identify critical factors that impact the adoption of cloud computing-based e-learning for Iraqi higher education organizations. Indeed, we identified the 14 critical factors that affect cloud computing uptake for e-learning system in higher education organizations such as compatibility, complexity, cost saving, security and privacy, integrity, and etc. This research examines the ideas and literature used to examine adoption of cloud computing to define future variables that may influence the adoption of cloud computing.
Effect of dry body weight on intra-dialytic hypertension in patients on regular hemodialysis
Authors: Mohamed Emad Allam , Abdelkader Ahamed Farag , Mostafa Mostafa Hassan 
Published: April 2022

Background: In chronic kidney disease, hypertension is influenced by both blood pressure (BP) and the progression of renal disease. In end stage renal disease (ESRD) on maintenance hemodialysis, hypertension is a main feature and more than 85% of new patients with ESRD present with hypertension. The aim of this study: was to assess the relationship between dry body weight and intra-dialytic hypertension in patients on regular hemodialysis. Patients and Methods: This was an observational cohort study with retrospective data analysis including (age and sex matched) patients with end stage renal disease. The study will be conducted in Nephrology Unit national institute of nephrology &urology. Results: there was statistically significant difference found between the two studied groups regarding LL edema, Sacral edema, Pl. effusion, Increased cardio/thoracic ratio, and Increased IVC diameter with (p-value= 0.016, 0.027, 0.019, 0.003 and 0.008) respectively. Conclusion: IDH is preventable if we control modifiable risk factors such as, reducing interdialytic weight gain, correction of serum albumin and urea reduction ratio. This will reduce cardiovascular morbidity and mortality in CKD patients on maintenance hemodialysis.
study of maternal and fetal risk factors associated with persistent pulmonary hypertension of newborn admitted in NICU in a Tertiary Hospital in Maharashtra
Authors: Sree Yalamanchili Sai , Joag Girish G. , Kshirsagar V. Y. 
Published: April 2022

Background: Persistent pulmonary hypertension of the new born (PPHN) associated with neurological injury later in life and this can be prevented by early detection and management. Early detection of PPHN is of utmost importance, especially in our country where the data available is very less and we cannot rely on the studies of developed countries due to the differences in the profiles of these neonates. This early detection requires knowledge of the risk due to associated factors. Aims and Objectives: To study, maternal and fetal risk factors, in neonates diagnosed with PPHN admitted in NICU in Krishna Hospital, Karad. Material and Methods: Study design: This was a single centre, Retrospective observational study based on secondary data done on 60 neonates diagnosed with PPHN in NICU from September 2020 to December 2021 in Krishna Hospital, Karad. Statistical Analysis: The statistical analysis was done with SPSS software version 22. Mean, standard deviation was calculated for continuous variables to know their central tendency. Chi square test was used to test the association between categorical variables and t test for continuous variables. A p<0.05 was taken as significant.
Prevalence of vitamin D deficiency among COVID-19 patients
Authors: Agrawal Bimal K. , Yadav Satya Prakash , Kalia Sahil , Yadav Ajit , Kumar Amit 
Published: April 2022

To determine the prevalence of Vitamin D deficiency among COVID-19 patients. The present study was conducted at Rural Tertiary Care Centre Designated COVID Care Hospital, MMIMSR Mullana Ambala, Haryana, India. The duration of the study was 1.5 months (Aug 2020 to Sep 2020). Those who tested positive in RT-PCR were taken from the wards and Flu clinic of the hospital. To calculate the sample size for cross-sectional study, enough literature for Vitamin D and COVID-19 in India was not available. Therefore, all patients were enrolled consecutively over 1.5 months. Data were collected on a pre-validated Case Recording Form. The demographic data of all the COIVD-19 patients were recorded. Comorbid conditions like diabetes and hyper- tension were also recorded. History of alcohol consumption and smoking was recorded. The sample for Vitamin D along with routine investigations was sent and the level of Vitamin D was estimated using chemiluminescence-based immunoassay analyzer. To understand the Vitamin D status among the different groups, deficiency, and insufficiency were calculated separately and compared. This study included 200 COVID-19 patients. Among total patients, males (57.5%) were represented more than females (42.5%). The mean age of the patients was 45.56 ± 26.23 years.
Diagnostic evaluation of alpha tumor necrosis factor and iron profile in newly diagnosed pulmonary tuberculosis with and without anemia
Authors: Yadav Priti , Divvi V.S. S Ramavataram , Shah Tejas 
Published: April 2022

Tuberculosis is the 9th leading cause of deaths worldwide. In chronic diseases such as pulmonary tuberculosis (PTB), inflammation due to bacterial burden play a vital role in patho-physiology of anaemia. Functions of erythropoietin (EPO) is affected by inflammation. The present study was an analytical type of case control study. The study included 100 newly diagnosed anaemic PTB cases and 50 newly diagnosed non anaemic PTB controls. PTB was confirmed by microscopic examination of sputum specimen for the detection of Acid-Fast Bacilli (AFB). Both cases and controls were subjected to iron profile and serum α-TNF were analysed by ELISA method. Significantly higher levels of α-TNF(214.56±82.30) was observed in anemic PTB cases than that of non-anemic PTB cases (p<0.001). Iron profile was also found significantly higher in anaemic PTB group in non anaemic PTB group. Significantly inverse correlation was observed between α-TNF and iron (r=-0.257, p<0.05) and α-TNF and Ferritin (r=-0.202, p<0.05) and Iron and Ferritin in both the groups. Increased α-TNF associated with increased bacterial burden and relatively decreased Iron. Cytokine-mediated defence against microbial pathogen causes effective withholding of iron within macrophages which affects erythropoiesis.
Testicular pain improvement after microsurgical subinguinal varicocelectomy
Authors: Elkousy Mohamed Magdy , Abdel-Rassoul Mohammed , Abdelrahman Sherif , Sayed Amr Moustafa 
Published: April 2022

Background: Approximately 2–10% of patients with varicocele complain of testicular pain. When conservative therapy fails to relieve the pain, Varicocelectomy is the surgical choice. The success rate of varicocelectomy for testicular pain has varied among studies. This prospective study aimed to investigate success rate of microscopic subinguinal varicocelectomy performed for the treatment of painful varicocele. Aim: To assess the efficacy of microsurgical subinguinal varicocelectomy for relief of testicular pain. Methods: The study was conducted at KasrAlainy school of medicine on 25 male patients who did not have infertility concerns and underwent microscopic subinguinal varicocelectomy with standard and pulling techniques after failed conservative treatment for 3 months. Results: 25 patients with testicular pain due to varicocele underwent microsurgical subinguinal varicocelectomy, 92% of patients had resolution of pain on follow up. Conclusion: Microscopic subinguinal varicocelectomy is an effective surgical alternative for testicular pain.
ASSOCIATION OF UPPER CROSS SYNDROME WITH PROLONGED SITTING AMONG YOUNG ADULTS
Authors: Khawar Arfa , Khawar Sara , Tauqeer Sana , Amjad Fareeha , Rubab Hafiza Iqra , Wafa Hafiza Sara 
Published: April 2022

To determine the frequency of upper cross syndrome and its association with prolonged sitting postures and to determine the functional status of upper extremity affected by prolong sitting among young population. METHODS: It was an analytical cross sectional study, conducted in Fatima Memorial College of Medicine and dentistry, Lahore from 18 October, 2017 to 30 January, 2018. Reed co postural assessment scale score was used for the postural assessment, upper limb functional index (ULFI) was used to inquire about the participant current upper extremity functional status in a variety of activities. RESULTS: Out of 165 participants who had 6 to 8 of sitting 15.75% had moderate level of difficulty and out of 150 participants who had 8 to 10 hours of sitting 26.66% had moderate level of difficulty, so significant association was found between sitting hours and upper extremity functional status with p=0.00. Postural analysis of head position, neck position, and upper back has also showed that there is significant association with p value =.000 (< 0.05) between sitting hours and postural changes, as increasing sitting hours cause increased postural changes. CONCLUSION: In the light of these results, it is concluded that prolonged sitting hours are associated with upper cross syndrome and change in upper extremity functional status, so certain strategies could be suggested for the workstations or the individuals, involves in prolong sitting.
A DESVALORIZAÇÃO DO ENSINO DE ARTE NO BRASIL: ORIGENS E ALGUNS ASPECTOS
Authors: RIBEIRO BENITES RITA DE CÁSSIA 
Published: April 2022

O presente artigo dialoga através de uma pesquisa bibliográfica com os fatos históricos que construíram o ensino de arte no Brasil e busca compreender os principais aspectos que influenciaram posicionamentos e ideais na concepção de arte-educação que conhecemos hoje. O texto discorre principalmente sobre desvalorização que a sociedade possui frente à disciplina entendendo suas origens desde o período colonial e seus desdobramentos a partir disto, atingindo as tendências modernas e reformas recentes. O levantamento dos questionamentos são referidos diante da também experiência profissional da interlocutora. O objetivo é analisar a historicidade do ensino da arte no Brasil desde os primórdios de forma a compreender os problemas que os arte-educadores da educação básica enfrentam e partir daí refletir sobre perspectivas futuras.
NITROGEN STARVATION INDUCED LIPID ACCUMULATION BY Chlorococcum infusionum (EAU-10) AS POTENTIAL RENEWABLE SOURCE OF LIPID FOR BIODIESEL PRODUCTION
Authors: Arguelles Eldrin De Los Reyes 
Published: April 2022

Microalgae are organisms effective of accumulating high quantity of industrially important lipids with promising characteristics as an excellent feedstock for biodiesel production. This study assess the possibility of using a green microalga, Chlorococcum infusionum (EAU-10) for biodiesel production by evaluating the growth characteristic, lipid yield and fatty acid profile of the microalga cultivated at varying concentrations of nitrogen source (0.375 - 1.50 g L-1 NaNO3). High lipid accumulation was observed in nitrogen-starved cultivation condition (0.375 g L-1 NaNO3) after 23 days of growth. Maximum biomass concentration of Chlorococcum infusionum (EAU-10) under nitrogen starved condition is 0.577 ± 0.003 g L−1 with 21.26% oil content per dry weight of algal biomass and lipid productivity of 22.08 mg L−1 day−1. Nitrogen starvation caused an increase in the total oil content and a decrease in biomass production of the microalga. Profiling of fatty acids of the obtained algal biodiesel shows methyl palmitate (C16:0) and methyl nonadecanoate (C19:0) contribute to almost 70% of Chlorococcum infusionum (EAU-10) fatty acid methyl esters (FAME) profile. Overall, a total of 74.58% of saturated fatty acid (SAFA) methyl ester content is present in the algal lipid, which is exceedingly high in contrast to other similar studies. Analysis of C. infusionum FAME profile in relation to some important fuel properties showed that the algal oil has the potential to produce biodiesel with excellent fuel qualities.
Humin-containing dosage form: technology, application prospects
Authors: Glubokova Maria N. , Avvakumova Nadezhda P. , Zhdanova Alina V. , Krivopalova Maria A. , Katunina Elena E. 
Published: April 2022

This article is devoted to the development of technology and methods for assessing the quality of suppositories containing humic acids of low-mineralized silt sulfide mud. The quality standards of the studied medicinal product were established and its stability during storage was determined. The quantitative determination of humic acids in aqueous solutions was determined by the spectrophotometric method.
When studying the technological indicators of the suppositories, the following indicators were taken into account: description, average weight, melting temperature and time of complete deformation.
The results of visual control showed that the appearance of the suppositories did not change during one year of storage. However, some white plaque and color heterogeneity appeared with the increase of the shelf life up to 1.5 years. The amount of the active substance during the storage of suppositories changed slightly and did not exceed the permissible content standards. The melting point value did not exceed 36 C, and its decrease was not observed. The time of complete deformation of the suppositories did not exceed 15 minutes and was 5-6 minutes during storage. The average weight of suppositories during storage remained stable. The study allows to conclude that the proposed suppositories are stable for 12 months and the preliminary shelf life of suppositories is 1 year.
The conducted chemical and pharmaceutical studies scientifically substantiate the expediency of using medicines with humic acids that demonstrate antioxidant and anti-inflammatory properties. This will expand the range of domestic medicines with the given spectrum of therapeutic action.
Effect of <i>Thymus marschallianus</i> extract on lipid peroxidation processes <i>in vivo</i> and <i>in vitro</i> experiments
Authors: Sheremetyeva Anna S. , Durnova Natalya A. , Chernysheva Yulia G. 
Published: April 2022

BACKGROUND: Currently, fundamental and experimental data confirming the role of free radicals in physiological and pathological processes have been accumulated. The literature describes conflicting information about the effect of antioxidants on the organism: they are able to protect not only normal cells from the alterative effect of free radicals, but also tumor cells, thereby supporting the survival and growth of the latter. Therefore, the study of the effect of Thymus marchallianus extract on the processes of lipoperoxidation in vivo against the background of the tumor process is relevant.
AIM: To study the effect of Thymus marchallianus extract on the quantity of lipid peroxidation intermediates in the blood plasma of mongrel white rats with liver cancer PC-1 and compare with in vivo antioxidant activity.
MATERIALS AND METHODS: The object of research was the dried Thymus marchallianus grass. Water and alcohol extracts were used in the experiment. Fifteen male white mongrel rats with a tumor were included in the experiment: the first group was intact, the second group received the water extract of Thymus marchallianus, and the third group received the alcohol extract of Thymus marchallianus. The activity of lipoperoxidation processes was evaluated, the content of intermediate lipid peroxidation intermediates malon dialdehyde, lipid hydroperoxides and medium-mass molecules in the blood plasma of experimental rats were estimated by means of conventional spectrophotometric methods. Determination of the antioxidant activity of the infusion and alcohol extraction in the in vitro experiment was carried out by the titrimetric method.
RESULTS: In the control groups and the group of animals that received intraperitoneal water and alcohol extracts of Thymus marchallianus, increase in the intermediate products of lipid peroxidation was not revealed. The amount of malon dialdehyde, lipid hydroperoxides and medium-mass molecules in the blood plasma of experimental rats did not differ significantly from the level of similar indicators of intact animals. In the in vitro experiment, water and alcohol extracts from raw Thymus marchallianus showed antioxidant activity.
CONCLUSIONS: For the first time, the experiment was conducted to study the effect of water and water-alcohol extracts of Thymus marchallianus on lipoperoxidation processes in mongrel white rats with alveolar liver cancer PC-1. The activity of formation of intermediate products of lipid peroxidation did not change, since their content in the blood plasma of experimental animals did not differ from the level of similar indicators of intact animals. In vitro the infusion and alcohol extract demonstrated antioxidant activity.
Medicines with active pharmaceutical ingredient diosmin: plaining of sample preparation
Authors: Voronin Alexander V. , Karpov Alexander V. 
Published: April 2022

BACKGROUND: Most drugs in the form of tablets contain diosmin in the micronized flavonoid fraction. This is the reason for the low level recovery by means of solid-liquid extraction.
AIM: to determine optimal conditions for sample preparation of some drugs with active pharmaceutical ingredient diosmin with the use of mathematical experiment planning (Box-Behnken design).
MATERIALS AND METHODS: The study subjects were tablets Detralex 1000 mg, Venarus 900 mg, Detravenol 1000 mg, Flebaven 1000 mg, Phlebopha 600 mg, Phlebodia 600 mg. Estimation of diosmin recovery by the method of solid-liquid extraction was made according to the algorithm of full factorial design with three level factors (Box-Behnken design).
RESULTS: The effect of some factors determining the extraction of diosmin from tablets Detralex 1000 mg, Venarus 900 mg, Detravenol 1000 mg, Flebaven 1000 mg, Phlebopha 600 mg, Phlebodia 600 mg was estimated. Mathematical (regression) models of solid-liquid extraction of diosmin for each drug were developed. The most significant factor determining the diosmin recovery from drugs (tablet formulation) is the sodium hydroxide concentration. Other factors (acetonitrile concentration, extraction time, centrifugation time, addition of ammonium sulfate) fail to exert significant effect. The optimal value of sodium hydroxide concentration is 0.02 mol/l. Diosmin recovery doesnt increase after the increase of the sodium hydroxide concentration above 0.02 mol/l.