bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Modafinil (Provigil) on Memory and Learning in Experimental
and Clinical Studies: From Molecular Mechanisms to Behaviour Molecular
Mechanisms and Behavioural Effects
Authors: Rahmani Mohammad Reza , Zamanian Mohammad Yassin , Karimvandi Mahdi Najafiani , Nikbakhtzadeh Marjan , Zahedi Elham , Bokov Dmitry Olegovich , Kujawska Małgorzata , Heidari Mahsa 
Published: September 2022

Abstract:
Modafinil (MOD, 2‐diphenyl‐methyl‐sulphinil‐2‐acetamide) is a stimulant-like medicine
used to treat narcolepsy. Off-label uses include improving cognitive ability in the course of
other diseases. This review aims to discuss findings demonstrating the memory and learningenhancing
activity of MOD in experimental and clinical studies. We included behavioral evaluations
alongside the effects of MOD at the cellular and molecular level.
MOD in different animal disease models exerted beneficial effects on induced memory and
learning impairment, which in some cases were accompanied by modulation of neurotransmitter
pathways or neuroplastic capabilities, reducing oxidative stress, or expression of synaptic proteins.
Individuals treated with MOD showed improved memory and learning skills in different
conditions. These effects were associated with regulating brain activity in some participants, confirmed
by functional magnetic resonance imaging.
Presented herein, data support the use of MOD in treating memory and learning deficits in various
disease conditions.
Histopathological Evaluation of Nanocurcumin for Mitigation of Radiation-
Induced Small Intestine Injury
Authors: Bagheri Hamed , Najafi Masoud , Ghanbarzadeh Alireza , Farhood Bagher , Noodeh Farshid Alazmani , Mosaed Reza , Hassanzadeh Gholamreza 
Published: September 2022

Aim:
In the current study, we aimed to mitigate radiation-induced small intestinal toxicity
using post-irradiation treatment with nano-micelle curcumin.

Background:
Small intestine is one of the most radiosensitive organs within the body. Wholebody
exposure to an acute dose of ionizing radiation may lead to severe injuries to this tissue and
may even cause death after some weeks.

Objective:
This study aimed to evaluate histopathological changes in the small intestine following
whole-body irradiation and treatment with nanocurcumin.

Materials and Methods:
Forty male Nordic Medical Research Institute mice were grouped into
control, treatment with 100 mg/kg nano-micelle curcumin, whole-body irradiation with cobalt-60
gamma-rays (dose rate of 60 cGy/min and a single dose of 7 Gy), and treatment with 100 mg/kg
nano-micelle curcumin 1 day after whole-body irradiation for 4 weeks. Afterward, all mice were
sacrificed for histopathological evaluation of their small intestinal tissues.

Results:
Irradiation led to severe damage to villi, crypts, glands as well as vessels, leading to
bleeding. Administration of nano-micelle curcumin after whole-body irradiation showed a statistically
significant improvement in radiation toxicity of the duodenum, jejunum and ileum (including
a reduction in infiltration of polymorphonuclear cells, villi length shortening, goblet cells injury,
Lieberkühn glands injury and bleeding). Although treatment with nano-micelle curcumin showed
increased bleeding in the ileum for non-irradiated mice, its administration after irradiation was
able to reduce radiation-induced bleeding in the ileum.

Conclusion:
Treatment with nano-micelle curcumin may be useful for mitigation of radiationinduced
gastrointestinal system toxicity via suppression of inflammatory cells’ infiltration and
protection against villi and crypt shortening.
Effect of A Stress Management Program on the Stress and Occupation of Chiang Mai University Students
Authors: Joompathong Natthanit , Bunrayong Wannipa , Chupradit Supat 
Published: September 2022

Background:Stress is a problem that is often found in students due to their own expectations within themselves and those of others which students have to bear. Furthermore, stress occurs from the changes at the personnel, social, and environmental levels. This stress has an effect on the occupation of students.Objective:This study was conducted to develop a stress management program and increase the capacity in the occupational performance of Chiang Mai University students.Methods:This study was quasi-experimental research that undertook an experiment according to the two-group research design. This measured both the pretest and post-test results of the experiment. The study used purposive sampling with a total of 24 samples comprising 12 persons in the experimental group and 12 persons in the control group. The experimental group joined the program eight times or for eight weeks one time per week for 90 minutes. This utilized the technique of managing the stress, which consisted of stress management skills and stress relaxation techniques. The sample was evaluated with an evaluation form. Moreover, the Suanprung Stress Test-20 and Test-60 were used, as well as an evaluation form of the occupational performance of the students, which was adapted from a similar form of the Canadian Occupational Performance Measure (COPM). This was conducted before and after joining the program, so to gather information, an analysis on the information by using the independent t-test to compare the experimental group and the control group before and after receiving the stress management program, as well as the dependent t-test was conducted. Information analysis was carried out to compare the samples in the same group.Results:After receiving the stress management program, the experimental group had less stress, which had statistical significance. There was also greater capacity in the occupational performance that also displayed statistical significance. The result of joining the program was different from the control group, that had a statistical significance level of 0.05. In the control group, the people who lived their daily life, as usual, showed no difference between stress and occupational performance.Conclusion:The studied results showed the effectiveness of the stress management program in reducing stress and increasing the occupational performance of Chiang Mai University students. This could be implemented as a prototype of the program to solve the problems created from the stress of Chiang Mai University students. This would also have a positive effect on future occupational therapy.
Platinum(II) Complexes of 3-Hydroxypyridine-2-Carboxaldehyde, N(4)-Methyl
and N(4)-Pyrrolidinyl Thiosemicarbazones: Synthesis, Characterization, and
Primary Anticancer Screening against HeLa Cells, and Molecular Docking
Authors: Yadav Paras Nath , Pokharel Yuba Raj , Sharma Shivani , Sharma Motee Lal , Rauf Abdur , Rahid Umer 
Published: September 2022

Background:
Thiosemicarbazones are an important class of synthetic organic compounds exhibiting promising biological activities; antiviral, antibacterial, antitubercular, antiprotozoal, antimalarial, antifungal, enzyme inhibitory and antitumor. Different α-(N)-heterocyclic thiosemicarbazones are potent inhibitor of ribonucleotide reductase enzyme that play a critical role in DNA synthesis, moreover some have been found 1000-fold more potent than the clinical drug hydroxyl urea.

Objective:
Different coordination complexes have been assessed for their efficacy to target MDR and surpass side effects associated with platinum drugs. In this work, we have prepared and investigated the anticancer potential of new platinum compounds of 3- hydroxy-2-formylpyridine thiosemicarbazones.

Methods:
Novel Pt(II) complexes, were synthesized and characterized by elemental analyses, FT-IR, 1H-NMR, UV-Visible spectroscopy and mass spectrometry. The in vitro anticancer activity of the synthesized compounds against HeLa cells by MTT assay was assessed. Protein-fixed and ligand-flexible Docking studies were carried out using Lamarckian genetic algorithm and Auto dock 4.2 software.

Results:
The IC50 values of compounds (3) and (4) through MTT screening against HeLa cells were found 107.16 µM and 132.13 µM respectively. The binding energy value for the complex [Pt(HyPyMe)Cl] was -6.49 kcal/mol. While for complex, [Pt(HyPyPyrd)Cl] was found to have a binding energy value of -6.83 kcal/mol.

Conclusion:
The spectroscopic and analytical data showed the mononuclear structures and square planar geometry of the Pt(II) complexes. The compounds exhibited moderate antineoplastic activity and N(4)-methyl substituted compound exhibited better anticancer activity. [Pt(HyPyMe)Cl] complex forms Hydrogen bond interactions with guanine-6, guanine-7 and thiamne-8. While [Pt(HyPyPyrd)Cl] interacts with guanine-7 and guanine-16 via hydrogen bond interaction.
A State-of-the-Art Review on Opioids Induced Constipation and its
Management
Authors: Benival Derajram , Longare Suraj , Rana Dhwani , Salave Sagar 
Published: September 2022

Background:
Pain is a complex physiological and psychological response to a noxious stimulus, sometimes deteriorating a patient’s quality of life. Opioids remain the mainstay treatment modality for chronic pain. Several concerns are raised regarding the long-term use of opioids and the risks associated with their usage. Findings advocate that the longstanding practice of opioid consumption manifests in adverse effects.

Objective:
Due to the physiological changes opioids instigate in the gastrointestinal tract, opioid-induced constipation remains a common complication pragmatic in patients undergoing opioid medications. Several therapeutic interventions are made available, and the review describes the overall medications with practical examples, aiding in selecting a treatment plan.

Methods:
The method comprises data collection from various search engines like PubMed, ScienceDirect, and SciFinder to get coverage of relevant literature for accumulating appropriate information regarding pain management, opioids, opioid-induced constipation, and its pharmacological interventions.

Results:
The thoughtful custom of exploring several options to manage opioid-induced constipation must allow patients to benefit from opioid analgesia.

Conclusion:
This paper reviews the role of opioids in pain management, underlying mechanisms of their action, opioid-induced constipation, and pharmacological therapies, with experimental studies aiding clinicians to optimise treatment plans.
Feature Extraction and Identification of Sugarcane Bud Based on S Component
in HSV Model
Authors: Xu Hongzhen , Li Qiang , Liu Jiaodi , Duan Yulong 
Published: September 2022

Background:
Accurate identification and positioning of sugarcane buds is not only the prerequisite for the automatic cutting of sugarcane bud, but also the premise of intelligent directional planting of sugarcane.

Objective:
In this study, a feature extraction and recognition method for sugarcane bud was proposed based on the S component in HSV model to identify the position of sugarcane bud center in the sugarcane seed image.

Method:
According to the observation and analysis of 3D image of the S component in a single sugarcane bud segment after median filtering, the S component value of the stem node area containing the sugarcane bud was concentrated, and there were continuous depressions on the edge of the sugarcane bud. A rectangular template with width of 350 pixels and step length of 35 pixels was created to search for the position with the maximum average component value, so as to indirectly determine the position of the stem node. The 3D geometric space of the S-component was analyzed, and the characteristics of the edge of sugarcane bud in the longitudinal section curve were extracted as the troughs. Finally, the characteristic parameters of the sugarcane bud were used to determine the size and position of the ellipse that approximated the shape of the sugarcane bud, indirectly locate the sugarcane bud, and effectively retain the characteristic information of the sugarcane bud.

Results:
The test results showed that the success rate of sugarcane bud identification was 90%, and it took 1.58 s to identify an image on average.

Conclusion:
The method can effectively reduce the deviation of the location of sugarcane bud center, prevent the sugarcane bud damage due to the wrong location of the sugarcane bud and the low germination rate caused by the sugarcane bud facing downward during the planting process, and provide a research foundation for the intelligent and precise planting of sugarcane.
Voltage Regulation Strategy of Distribution Network with Decentralized
Wind Power Based on Cluster Partition
Authors: Li Wei , Su Shi , Lei Jinyong , Yan Yuting , Pan Shuhui , Yang Yang , Bai Hao , Chen Jun , Zhao Qindao 
Published: September 2022

Background:
With the access to large-scale distributed energy, the voltage off-limit
problem of the distribution network has become more and more serious, and the traditional centralized
voltage control method has been difficult to meet the demand of distribution network control
and market development.

Methods:
In this paper, a voltage regulation strategy based on decentralized wind power clustering
is proposed. Considering the active and reactive power regulation ability of decentralized
wind power, based on the cluster division of distributed energy, the goal is to minimize power
regulation and voltage fluctuation within the cluster. Combining the K-means clustering algorithm
and optimized PSO algorithm for voltage regulation within the cluster ensures that the voltagecrossing
problem is solved. After the voltage regulation of all clusters, the auxiliary service transaction
of voltage regulation is implemented to complete the voltage regulation of the whole network.

Results:
Taking ieee33 bus system as an example, the MATLAB simulation shows that the decentralized
wind power access triggered voltage overrun. Using the proposed cluster division method
to cluster the model, the clustered voltage regulation of the nodes with voltage overrun or reaching
the limit resulted in greater voltage down-regulation than the overall voltage regulation.

Conclusion:
The proposed voltage regulation strategy has better advantages. It is verified that the
proposed voltage regulation strategy not only solves the voltage overrun problem, but also reduces
voltage fluctuations and the amount of power regulation used for voltage regulation, increasing
the utilization of distributed energy with better superiority.
Replacement of LVDS to HVDS for Reduction in Distribution Losses,
Improvement in Voltage Profiles and Economic Analysis for National
Saving
Authors: Chauhan Rajeev Kumar , Maurya Sanjay Kumar , Chauhan Durg Singh 
Published: September 2022

Introduction:
Rural electrification in India is planned with high-capacity distribution
transformers which supply the isolated location loads of various categories like agricultural,
household, small business, etc. This distribution system planning with non-optimal distribution
transformers leads to poor voltage profiles and high power losses in the distribution network. This
paper presents that a High-Voltage Distribution System (HVDS) is more suitable than a Low-
Voltage Distribution System (LVDS).

Methods:
A model is developed to evaluate the technical losses, voltage profiles, and optimal
payback period of the investments for the planned HVDS network. The replacement of LVDS
with HVDS is achieved by replacing high-capacity distribution transformers with small-capacity
at optimal locations.

Results:
The results of this study are validated on the real 11kV agricultural feeder of the
Narshinghpur District of Madhya Pradesh, India.

Conclusion:
The results demonstrate improvement in voltage profiles, low power losses, and optimal
payback period for the proposed problem. The obtained results proved that the replacement
of LVDS with HVDS would be more beneficial for rural electric power distribution system
planning.
WITHDRAWN: A Review on Oxygen-Deficient Titanium Oxide for Photocatalytic
Hydrogen Production
Authors: Peng Zhijian , Chen Yan , Fu Xiuli 
Published: September 2022

The article has been withdrawn at the request of the authors of the Journal of Photocatalysis.

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Medicinal Importance and Pharmacological Activities of Sciadopitysin in
the Medicine: Drug Target for Neuroprotection, Myocardial Infarction,
Alzheimer’s Disease, Diabetes, and Related Complications
Authors: Patel Kanika , Patel Dinesh Kumar 
Published: September 2022

Backgrounds:
Herbal medicines have been used in the medicine over the last three decades and demand of herbal drugs has been increasing in the modern medicine due to their health beneficial aspects and pharmacological activities. Herbal medicines were mainly derived from the plants and their derived products which have significant role in the traditional and modern system of medicine. Plant based products have been used in the preparation of numerous health product including some of the modern pharmaceutical preparation. Ginkgo biloba is one of the important medicinal plants of the herbal medicine, which contain significant amount of sciadopitysin.

Methods:
Biological importance and therapeutic benefit of sciadopitysin have been investigated in the present investigation through scientific data analysis of different scientific research work in order to know the therapeutic potential of sciadopitysin in the medicine. Pharmacological activities of sciadopitysin have been searched and analyzed in the present work through different literature databases. Modern analytical tools for the isolation and quantification of sciadopitysin have been also discussed in the present work to know the therapeutic value of sciadopitysin in the medicine.

Results:
Scientific data analysis of different research work revealed the biological importance and therapeutic benefit of sciadopitysin which is a biflavonoids class phytochemical found to be present in the Ginkgo biloba. Scientific data analysis of present work revealed the biological importance of sciadopitysin in the medicine for the treatments of human health complications against diabetes and its complications, osteoclastogenesis, myocardial infarction, Alzheimer’s disease, hepatic and renal toxicity, inflammatory disorders, osteoporosis, human skin disorders, lymphocyte proliferation and fungal diseases. Further scientific data analysis revealed the importance of standardization of plant materials and their derived products through sciadopitysin in the medicine.

Conclusion:
Scientific data analysis of collected research work revealed the biological importance of sciadopitysin in the medicine for their effectiveness against human health complications.
Atorvastatin Efficacy in the Management of Mild to Moderate
Hospitalized COVID-19: A Pilot Randomized Triple-blind Placebo-
controlled Clinical Trial
Authors: Hejazi Sepideh , Mircheraghi Farzam , Elyasi Sepideh , Davoodian Najmeh , Salarbashi Davoud , Mehrad-Majd Hassan 
Published: September 2022

Background:
Statins are first-line lipid-lowering agents with tolerable adverse
reactions, low cost, and high availability worldwide. The potent anti-inflammatory,
antioxidant, anti-thrombotic and immunomodulatory effects of statins propose
them as an option against COVID-19 infection.

Objective:
In this randomized triple-blind placebo-controlled clinical trial, we have investigated
the atorvastatin efficacy in the management of mild to moderate hospitalized
COVID-19 patients.

Methods:
In this study, 52 mild to moderate hospitalized COVID-19 patients who fulfilled
the inclusion criteria were allocated to the treatment group to receive 40 mg
atorvastatin orally once daily for two weeks (n=26) or the placebo group (n=26). Patients'
symptoms and laboratory investigations were assessed at baseline and during the
follow-up period. We also evaluated the duration of hospitalization and supplemental
oxygen therapy as endpoints.

Results:
After 14-day of follow-up, the oxygen saturation (SaO2) was significantly
higher, and the serum high sensitivity C-reactive protein (hs-CRP) level was lower in
the treatment group compared to the placebo group. Moreover, at the end of the followup
in the treatment group, the lymphocyte count was higher, and the duration of symptom
resolution was shorter but not significant. Additionally, in the treatment group, the
length of supplemental oxygen therapy and hospitalization duration were meaningfully
shorter. Our results revealed that the mortality rate was almost twice higher in the placebo
group compared to the treatment group, without any significant adverse drug reaction.

Conclusion:
Atorvastatin significantly reduces supplemental oxygen need, hospitalization
duration, and serum hs-CRP level in mild to moderate hospitalized COVID-19 patients.
Berberine Recovered Oxidative Stress Induced by Sodium Nitrite in Rat Erythrocytes
Authors: Barazesh Mahdi , Jalili Sajad , Akhzari Morteza , Farzinezhadi Zadeh Mohammad Mahdi 
Published: September 2022

Objective:Berberine, a plant derived alkaloid, present in Berberis species and is well known as one of the most important antioxidants. The current research aimed to study the heamatoprotective characteristics of berberine and clarify its plausible mechanisms against sodium nitrite.Methods:Forty numbers of male Sprague Dawley rats were categorized into five equal groups, including group 1: control (normal saline); group 2: berberine (100 mg/kg); group 3: sodium nitrite (80 mg/kg); group 4: sodium nitrite (80 mg/kg) plus berberine (50 mg/kg) and group 5: sodium nitrite (80 mg/kg) plus berberine (100 mg/kg) groups. All animals were orally administrated for two months once daily. At the end of the 60th day, blood samples were withdrawn by cardiac puncture and collected in test vials when the animals had been anesthetized with ketamine (70 mg/kg). Then, hemolysate was prepared and the oxidative stress biomarkers, lipid peroxidation, and antioxidant capacity of erythrocytes were evaluated.Results:Feeding of rats with sodium nitrite remarkably enhanced malondialdehyde (MDA) (p=0.001) levels and considerably reduced the levels of glutathione (GSH) (p=0.001), and also reduced the enzymatic activities of glutathione peroxidase (GPx) (p=0.02), superoxide dismutase (SOD) (p=0.001), glutathione reductase (GR) (p=0.02), and catalase (CAT) (p=0.01). However, the co-administration of these animals with 100 mg/kg of berberine remarkably reverted the values to reach nearly a normal level. While 50 mg/kg berberine failed to restore significantly all of these antioxidant biomarkers at a normal level.Conclusion:Our results clearly demonstrated that berberine in a dose-dependent manner led to protection against sodium nitrite-induced oxidative injury in rat erythrocytes, which possibly reflects the antioxidant ability of this alkaloid.