bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Mechanical and Wear Properties of Ceramic and Inorganic compounds based Composite via PM route and Optimization through Robust design technique
Authors: P SURESHKUMAR , kumar suresh , Jagadeesha T. , Natrayan L. , Ravichandran M. , Veeman Dhinakaran , SM Muthu 
Published: January 2022

Abstract
The present research study investigates the Mechanical, Physical, and Tribological properties of powder metallurgy (PM) produced AA6063 alloy reinforced with silicon nitride (Si3N4) and copper nitrate (CuN2O6). Incorporation of Si3N4 & CuN2O6 reinforcement in matrix material ranged from 6 to 12 % Si3N4 in a 6-step interval and 2 to 6 %CuN2O6 in a two-step interval. The characterizations were made on the PM-produced specimens using OM, EDS, XRD, and Hardness. The reinforcement particles were uniformly distributed, which was attributed to a homogeneous mixer of matrix and reinforcements. The test findings show that as the reinforcing percentage of the ceramic and inorganic compound increases, properties such as hardness and density rise considerably and monolithically. The existence of phases such as Si3N4 and CuN2O6 reinforcement in the AA6063 matrix was ensured by X-ray diffraction. The hardness of AA6063/12%Si3N4/6%CuN2O6 increased by 88% over the base alloy due to a mismatch in thermal expansion between the Al matrix and reinforcement, which causes massive internal stress, causing the aluminium matrix to plastically deform to accommodate the reduced volume expansion of Si3N4 and CuN2O6 particles. The dry sliding wear test was determined using the Pin-on-Disc method, and the results show that the composite is more wear-resistant. An orthogonal array and analysis of variance were utilized to evaluate the solution, including parameters using the Taguchi robust design technique. The weight percentage of the Si3N4/CuN2O6 compound and the relationship between weight % of reinforcement and applied load had the most significant impact on composite wear resistance. The produced composite's wear morphology was studied using images from a scanning electron microscope and energy dispersive spectroscopy.
Transcription Elongation Factor A (SII) -Like (TCEAL) Gene Family Member-TCEAL2: A Novel Prognostic Marker in Pan-Cancer
Authors: Sun Yu , Zhao Jun 
Published: January 2022

Abstract
Background: Cancer is the leading cause of death in the world. The mechanism is not fully elucidated and the therapeutic effect is also unsatisfactory. In our study, we aim to find new target gene in pan-cancer.Methods: Differentially expressed genes (DEGs) was screened out in various types of cancers from GEO database. The expression of DEG (TCEAL2) in tumor cell lines, normal tissues and tumor tissues was calculated. Then the clinical characteristics, DNA methylation, tumor infiltration and gene enrichment of TCEAL2 was studied. Results: TCEAL2 expressions were down-regulated in most cancers. Its expression and methylation were positively or negatively associated with prognosis in different cancers. The tumor infiltration results revealed that TCEAL2 was significantly related with many immune cells especially NK cells and immune-related genes in majority cancers. Furthermore, tau protein and tubulin binding were involved in the molecular function mechanisms of TCEAL2. Conclusion: TCEAL2 may be a novel prognostic marker in different cancers and may affect tumor through immune infiltration.
Anatomical and Visual Effects of Implantable Phakic Contact Lens on Correction of Myopia
Authors: Ekram Mahmoud , Elshafei Ahmed Mohamed Kamal , Mohamed Asmaa Anwar , Abdelkader Mohamed Farouk Sayed Othman 
Published: January 2022

Abstract
Purpose: To evaluate the anatomical effects of implantable phakic contact lens (IPCL) (Care Group, India) on anterior segment and its visual outcomes .Patients and methods: In a prospective interventional case series study, 60 highly myopic eyes of 32 patients were subjected to IPCL implantation in the Ophthalmology Department of Minia University Hospital, Egypt from January 2019 to June 2021. All patients had complete ophthalmic examination and were followed up for 1 year. Pentacam was used for preoperative and postoperative estimation of anterior chamber depth (ACD), anterior chamber angle (ACA), anterior chamber volume (ACV) and IPCL vault in the 1st, 3rd, and 12th months. Assessment of corneal endothelium was done using specular microscope preoperatively and after 12 months. Preoperative and postoperative refraction and visual acuity were measured. Results: There was a statistically significant decrease in ACD, ACA, and ACV. There was no significant difference between preoperative and postoperative mean intraocular pressure (IOP) by the 12th month (P=0.163). The mean preoperative endothelial cell count (ECD) was significantly reduced from 2929.3±248 cells/mm2 to 2737.9±303 cells/mm2 at the 12th month (P<0.001). with a statistically highly significant improvement of mean Log Mar uncorrected visual acuity (UCVA) from 1.48±0.19 preoperatively to 0.46±0.11 by the end of follow up (P<0.001) with insignificant difference between preoperative best corrected visual acuity (BCVA) and postoperative UCVA (P=0.209). In the 12th month, the mean vault was 240±540 μm. No sight threatening complications occurred.Conclusion: Although IPCL induced anatomical changes, it was safe and effective for correction of high myopia.
Site-specific gains and losses of heterochromatin accelerate the age-related neurodegeneration through the cascading destruction of KDM3B-centered epigenomic network
Authors: An Mi-Jin , Kim Ji-Young , Park Jinhong , Kim Jinho , Kim Dae-Hyun , Shin Geun-Seup , Lee Hyun-Min , Jo Ah-Ra , Kim Chul-Hong , Kim Mi Jin , Kim Jeongkyu , Rhee Sangmyung , Seo Sang-Beom , Kim Jung-Woong 
Published: January 2022

Abstract
Epigenetic alterations explained by the “loss of heterochromatin” model have been proposed as a universal mechanism of aging, but the region-specific changes of heterochromatin during aging are unclear. Here, we examine age-dependent transcriptomic profiling of mouse retinal neurons to identify epigenetic regulators involved in heterochromatin loss. RNA sequencing analysis revealed gradual down-regulation of Kdm3b during retinal aging. Disruption of Kdm3b (Kdm3b+/-) in 12-month-old mouse retina decreased the number of cone photoreceptors and changed the morphology of cone ribbon synapses. Integration of transcriptome profiling with epigenomic analysis demonstrated gain of heterochromatin feature in synapse assembly and vesicle transport genes via the accumulation of H3K9 mono- and di-methylation. However, the loss of heterochromatin in apoptotic genes exacerbated retinal neurodegeneration. We propose that this KDM3B-centered epigenomic network is crucial for maintaining cone photoreceptor homeostasis via the modulation of gene-set specific heterochromatin features during aging.
Facial Nerve Involvement During Temporal Bone Resection: Overall Survival And Locoregional Recurrence Outcomes.
Authors: Gendre Adrien , Jones Holly , McHugh Alison , Hintze Justin , Martin Fiachra , O'Sullivan Barry , Walsh Rory McConn , O'Neill James Paul , Shine Neville 
Published: January 2022

Abstract
Purpose: Facial nerve resection is often required in lateral temporal bone resection for tumors extending to the lateral skull base. Limited data exists to guide facial nerve reanimation strategies. Methods: This is a retrospective cohort study. Patients undergoing lateral temporal bone resection in a national referral center were included and divided into two groups: facial nerve preservation or resection. Survival and locoregional recurrence outcomes were analyzed by Kaplan-Meier survival analysis. Prognostic factors were identified using univariate and multivariate analysis. Facial nerve reconstructive methods were collected.Results: 39 patients were included with 20 having facial nerve resection at surgery. Squamous cell carcinoma (SCC) was the most common pathology. 48% of patients died during follow-up. Mean overall survival (OS) was 27 months and mean time to locoregional recurrence (LRR) 23 months in the facial nerve preservation group. Mean OS was 16 months and mean time to LRR was 13 months in the facial nerve resection groups (logrank OS p=0.330 and LRR p=0.445). 75% of patients in the facial nerve resection group had static facial nerve reanimation using tarsorrhaphy, gold-weight eyelid implant and fascia lata sling. Middle ear cavity extension was a negative predictor of OS and LRR.Conclusion: Facial nerve resection during lateral temporal bone surgery is associated with poor overall survival and locoregional control outcomes. Multidisciplinary surgical management and static facial reanimation should be offered to maintain function and quality of life in this group of patients.
Clinical Features and Surgical Management of Pituitary Adenoma During Pregnancy: Case Series and Literature Review
Authors: Jia Xinyu , Guo Xiaopeng , Luo Mingjie , Yao Yong , Lian Wei , Xing Bing 
Published: January 2022

Abstract
Purpose

Although conservative treatment was recommended for pregnant patients with pituitary adenomas (PAs), surgical treatment is occasionally necessary for those with acute symptoms. However, surgical intervention among these patients is poorly studied.
Methods

Six patients with PAs who underwent surgical treatment during pregnancy at Peking Union Medical College Hospital between January 1990 and June 2021 and another 35 pregnant patients profiled in the literature were included.
Results

All the 41 enrolled patients (mean age 29.8 ± 5.3 years) had acute symptoms including visual field defects, severe headaches, or vision loss requiring emergency pituitary surgeries. Mean tumor diameter was 2.16 ± 0.9 cm, and 92.6% were macroadenomas. PA apoplexies were found in 23 patients. The average gestation time at surgery was 25.1 ± 7.1 weeks; 55.9% of these patients underwent surgery in the second trimester of pregnancy. Multidisciplinary team was involved from before surgery to after delivery. Except one patient underwent an induced abortion, and one fetus died due to a nuchal cord, thirty-nine patients delivered successfully, and 37 of fetuses were healthy till the last follow-up. One fetus died of congenital diaphragmatic hernia, and another had a low Apgar score after a cesarean section but survived.
Conclusion

PA surgery for pregnant patients with PAs is effective and safe during the second and third trimesters. Pregnant patients requiring emergency PA surgery need multidisciplinary evaluation and healthcare management. Cooperation of neurosurgery, endocrinology, obstetrics, anesthesiology, and neonatology is necessary for a successful surgical intervention for pregnant patients with PAs.
Machine Learning-Assisted Identification of Factors Contributing to the Technical Variability Between Bulk and Single-Cell RNA-Seq Experiments
Authors: Lipnitskaya Sofya , Shen Yang , Legewie Stefan , Klein Holger , Becker Kolja 
Published: January 2022

Abstract
Background: Recent studies in the area of transcriptomics performed on single-cell and population levels reveal noticeable variability in gene expression measurements provided by different RNA sequencing technologies. Due to increased noise and complexity of single-cell RNA-Seq (scRNA-Seq) data over the bulk experiment, there is a substantial number of variably-expressed genes and so-called dropouts, challenging the subsequent computational analysis and potentially leading to false positive discoveries. In order to investigate factors affecting technical variability between RNA sequencing experiments of different technologies, we performed a systematic assessment of single-cell and bulk RNA-Seq data, which have undergone the same pre-processing and sample preparation procedures. Results: Our analysis indicates that variability between gene expression measurements as well as dropout events are not exclusively caused by biological variability, low expression levels, or random variation. Furthermore, we propose FAVSeq, a machine learning-assisted pipeline for detection of factors contributing to gene expression variability in matched RNA-Seq data provided by two technologies. Based on the analysis of the matched bulk and single-cell dataset, we found the 3'-UTR and transcript lengths as the most relevant effectors of the observed variation between RNA-Seq experiments, while the same factors together with cellular compartments were shown to be associated with dropouts. Conclusions: Here, we investigated the sources of variation in RNA-Seq profiles of matched single-cell and bulk experiments. In addition, we proposed the FAVSeq pipeline for analyzing multimodal RNA sequencing data, which allowed to identify factors affecting quantitative difference in gene expression measurements as well as the presence of dropouts. Hereby, the derived knowledge can be employed further in order to improve the interpretation of RNA-Seq data and identify genes that can be affected by assay-based deviations. Source code is available under the MIT license at https://github.com/slipnitskaya/FAVSeq.
Impact of the Lorentz Force on Electron Track Structure and Early DNA Damage Yields in Magnetic Resonance-Guided Radiotherapy
Authors: Yachi Yoshie , Kai Takeshi , Matsuya Yusuke , Hirata Yuho , Yoshii Yuji , Date Hiroyuki 
Published: January 2022

Abstract
Magnetic resonance-guided radiotherapy (MRgRT) has been developed and installed in recent decades for external radiotherapy in several clinical facilities. The Lorentz force modulates dose distribution by charged particles in MRgRT; however, the impact by this force on low-energy electron track structure and early DNA damage induction remain unclear. In this study, we estimated features of electron track structure and biological effects in a static magnetic field (SMF) using a general-purpose Monte Carlo code, Particle and Heavy Ion Transport code System (PHITS) that enables us to simulate low-energy electrons down to 1 meV by track-structure mode. The macroscopic dose distributions by electrons above approximately 300 keV initial energy in liquid water are changed by both perpendicular and parallel SMFs against the incident direction, indicating that the Lorentz force plays an important role in calculating dose within tumours. Meanwhile, DNA damage estimation based on the spatial patterns of atomic interactions indicates that the initial yield of DNA double-strand breaks (DSBs) is independent of the SMF intensity. The DSB induction is predominantly attributed to the secondary electrons below a few tens of eV, which are not affected by the Lorentz force. Our simulation study suggests that treatment planning for MRgRT can be made with consideration of only changed dose distribution.
Metal-Polymer Complexes as Antibacterial Agents: Characterization and Antibacterial Activity of Metal-Polymer Nanocomposite Based on Copolymers of Polyethylene(Propylene)Glycolmaleates with Acrylic Acid
Authors: KHAMITOVA T.O. , BURKEEV M.ZH. , A.ZH.SARSENBEKOVA  , ISHMURATOVA M.YU. , G.K.MUKUSHEVA  , S.G.OSPANOVA  
Published: January 2022

Abstract
The article presents the results of the synthesis and study of the structure of metal-polymer complexes p-EGM: АА/Ag, p-EGM: АА/Ni, p-EGM:АА/Ag-Ni, p-PGM:АА/Ag, p-PGM:АА/Ni, p-PGM:АА/Ag-Ni based on copolymers of polyethylene(propylene)glycolmaleates with acrylic acid and metals, which have been characterized using microscopy, spectroscopy and thermogravimetry. The antimicrobial activity of a new metal-polymer nanocomposite p-PGM/АА-Ag was studied, which is showing high efficiency against standard strains of Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus.
Integrating Agricultural Diversification in China’s Major Policies for Sustainable and Resilient Crop Production
Authors: Wanger Thomas , He Xueqing , Weisser Wolfgang , Zou Yi , Fan Shenggen , Crowther Thomas 
Published: January 2022

Abstract
Agricultural diversification of intensified farming systems is being proposed as a solution for achieving both food security and agricultural sustainability, but so far there has been little implementation of such policy at a larger scale. In China, major policies promote the “High-standard farmland consolidation” (HSFC) strategy to improve productivity and reduce environmental degradation in the world’s largest food production areas by simplifying instead of diversifying landscapes on large instead of small fields. As China’s Central government is asking for scientific innovations to improve its sustainable development strategy, we argue that China can become a role model to integrate agricultural diversification in its major policies, if HSFC builds on five decades of diversification research to achieve the national food security and sustainable development goals. We use text mining to analyze the past 17 years of China’s most important agricultural policy, the No. 1 Central Documents (1CD) policy and show that agricultural diversification at the field and supply chain level has received limited attention. Based on global synthesis studies covering five decades of research, we provide practical recommendations of how to integrate agricultural diversification in the China’s major policies from the national (the National 5-Year Plan and 1CD) to the provincial level. We use the major agricultural commodities rice, tea, wheat, and rapeseed in Zhejiang province as a case study to discuss how diversification can help to reach China’s sustainable agriculture targets. Diversification of China’s major food production areas on small fields could be an important example globally of how scientific progress informs policy and facilitates the food system transition.
Effect of Percutaneous Electric Stimulation with High Frequency Alternating Currents on the Sensory-Motor System of Healthy Volunteers
Authors: Álvarez David Martín-Caro , Serrano-Muñoz Diego , Fernández-Pérez Juan José , Gómez-Soriano Julio , Avendaño-Coy Juan 
Published: January 2022

Abstract
BackgroundFormer studies investigated the application, both transcutaneous and with implanted electrodes, of high frequency alternating currents (HFAC) in humans for blocking the peripheral nervous system. The present trial aimed to assess the effect of HFAC on motor response, somatosensory thresholds, and peripheral nerve conduction, when applied percutaneously with ultrasound-guided needles at frequencies of 10 kHz and 20 kHz in healthy volunteers. MethodsA parallel, placebo-controlled, double-blind, randomized clinical trial was conducted. Ultrasound-guided HFAC at 10 kHz and 20 kHz and sham stimulation were delivered to the median nerve of 60 healthy volunteers (n=20 per group) for 20 minutes. The main assessed variables were maximum isometric flexion strength (MFFS) of the index finger, myotonometry, pressure pain threshold (PPT), mechanical detection threshold (MDT), and antidromic sensory nerve action potential (SNAP). Measurements were recorded pre-intervention, during the intervention 15 minutes after its commencement, immediately post-intervention, and at 15 minutes post-intervention.ResultsA decrease in the MFFS was observed immediately post-intervention compared to baseline, both in the 10 kHz group [-8.5 %; 95% confidence interval (CI) -14.9 to -2.1] and the 20 kHz group (-12.0%; 95%CI -18.3 to -5.6). At 15 minutes post-intervention, the decrease in the MFFS was -9.5% (95%CI -17.3 to -1.8) and -11.5% (95%CI -9.3 to -3.8) in the 10 kHz and 20 kHz groups, respectively. No changes over time were found in the sham group. The between-group comparison of changes in MFFS showed a greater reduction of -10.8% (95%CI -19.8 to -1.8) immediately post-intervention in the 20 kHz compared to the sham stimulation group. Muscle tone increased over time in both the 10 kHz and 20 kHz groups, but not in the sham group. The intergroup comparison of myotonometry showed a superior effect in the 20 kHz (6.7%, 95%CI 0.5 to 12.9) versus the sham group. No significant changes were observed in the rest of the assessed variables. ConclusionsThe ultrasound-guided percutaneous stimulation applying 10 kHz and 20 kHz HFAC to the median nerve produced reversible reductions in strength and increases in muscle tone with no adverse effects.
Study on Size-Related Product Quality of Multiscale Central-Punched Cups Fabricated by Compound Forming Directly Using Brass Sheet
Authors: Hu Dien , Zheng Jun-Yuan , Fu M. W. 
Published: January 2022

Abstract
Meso/microforming has gained much more attention in the last decades and is widely used as a reliable method to fabricate meso/micro-scaled metallic components. In this research, a compound meso/microforming system which combines deep drawing, punching and blanking operations was developed to fabricate multiscale central-punched cups by using brass sheets. The parts with three scales were produced by using the brass sheets with various thicknesses and grain sizes to investigate geometrical and grain size effects on the deformation behaviors, dimensional accuracy, and material flow behaviors in the forming process. Through physical experiments and finite element simulations, it is revealed that the ultimate deformation load in the drawing-punching stage is smaller than that in the single deep drawing stage under microscale, but the results in the meso-scaled scenarios are opposite. In addition, the thickness variation is increased with grain size, but the variation of the normalized thickness variation does not show an obvious tendency with different size scales. In the bending area, the material flow is tangential to the thickness direction, leading to the formation of thinning area. In addition, the material flow is almost opposite to the punching direction in the punching area, avoiding the expanding deformation of the hole. Thus, the punching operation barely affects the dimensional accuracy including the thickness and hole diameter of the formed parts. Furthermore, the micro-scaled cups with finer grains have a better surface quality. These findings enhance the understanding of size effect in compound meso/microforming with the combined deep drawing and punching operations.
Faulting of rocks as a critical energy process
Authors: Reches Ze'ev , Wetzler Nadav 
Published: January 2022

Abstract
Faulting of rocks is a dominant earth process that governs small-scale fracturing, formation of tectonic plate boundaries, and earthquakes occurrence1–4. Since the 18th century, the mechanical settings for rock faulting were commonly analyzed with the Coulomb criterion5 that offers empirical, useful tools for scientific and engineering applications1,6–12. Here we revisit the processes of rock faulting by an alternative approach that incorporates elastic energy, strain-state, and three-dimensional deformation; these mechanical fundamentals are missing in Coulomb criterion. We propose that a stressed rock-body fails as two conditions are met: (1) The elastic energy generated by the loading system equals or exceeds a critical energy intensity that is required for the faulting process; (2) The internal strain of the stressed rock-body due to slip and dilation along the developing faults equals the strain-state created by the loading system to maintain physical continuity13,14. Our simulations reveal that meeting these energy and strain conditions requires an orthorhombic, polymodal fault geometry that is similar to natural and experimental fault systems15–20. The application of our formulation to hundreds of rock-mechanics experiments11,21–28 provides a new, comprehensive benchmark for rock-faulting.