bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Lockdown and Mental Health Consequences among Farming Households in Nigeria
Authors: Olowogbon Toyin Samuel , Yoder Aaron Moses , Adebisi Luke Oloruntoba 
Published: February 2025

Aims
This study examined the mental health consequences of the COVID-19 lockdown among farming households in rural Nigeria.

Method
A structured questionnaire was utilised to elicit information from 585 crop farmers across four States in Nigeria. The collected data were analyzed using descriptive statistics and binary logistic regression.

Result
The mean age of respondents was 44 years, with an average farming experience of 21 years. The average farm size was found to be 2.4 hectares. About 56% of the respondents were able to identify COVID-19-induced farm business stress. About 70% reported they had experienced income loss due to the COVID-19 lockdown. About 54% of the respondents self-reported COVID-19-induced mental health stress. About 74% reported experiencing mental health effects in the form of headaches, 48% said anxiety, 44% reported worry, and 41% reported depression. Self-reported mental health coping strategies include rest (63%), social gathering (57%), religious gathering (52%), and the use of drugs (40%). Males were 3.7 times more likely to experience COVID-19-induced mental health issues from their farm business than their female counterparts. Single respondents were 2.44 times more likely to experience COVID-19-induced mental health issues from their farm business than their married counterparts. We also documented that households with larger family sizes had lower mental health stress. We also found that respondents with higher incomes had lower mental health stress.

Conclusion
We concluded that most farming households experienced COVID-19-induced mental health stress. Targeted mental health campaigns, support, and intervention are recommended to help farmers address mental health stressors.
MicroRNA-Mediated Regulation of Cancer Stem Cells: Implications for Radioresistance and Chemoresistance in Cancer Treatment
Authors: Loganathbabu Vasanth Kanth Thasma , Ganesh Harin N , Gor Ravi , Aruljothi Kandasamy Nagarajan , Ramalingam Satish 
Published: February 2025

Abstract:
MicroRNAs (miRNAs) are a class of noncoding RNAs that regulate gene expression in
cancer cells and Cancer Stem Cells (CSCs), and play an indispensable role in the development of
resistance to radiotherapy and chemotherapy in cancer treatment. The dysregulation of miRNAs in
CSCs plays a vital role in influencing the features of CSCs and their resistance mechanisms in
different forms of cancer. These miRNAs are also engaged in regulating important signaling pathways,
such as Notch and Wnt, which have an impact on the behavior of CSCs and their response to
treatment. The intricate network of miRNAs and their interactions with essential proteins and major
pathways highlight their potential as therapeutic targets for controlling cancer stem cell behavior
and improving the outcomes of cancer therapy by understanding their effects. Comprehending the
complex relationship among the production of microRNA, the environment surrounding the tumor,
and the processes by which cells communicate can provide vital knowledge for developing successful
treatments to overcome resistance to chemotherapy and radiation in cancer therapy.
An Overview of the Phytopharmacological Characteristics of Urochloa Distachya (L.) and Selected Forage Grasses (Poaceae)
Authors: Dash Smrutiranjan , S Rajasekaran , Hota Raghunandan , Mohanty Arnabaditya , Das Chandan 
Published: February 2025

Background:
The Poaceae families make up the majority of crops and animal feed. We
address a comprehensive analysis of the phytopharmacological characteristics of a few species
from the Poaceae family, including Urochloa distachya, Brachiaria decumbens, Brachiaria brizantha,
Eleusine indica, and others.

Objective:
The primary objective of this study was to offer detailed information on the phytocompounds
found in different parts of the plant and their pharmacological activities. Additionally, we
explored the previous pharmacological activity of these plants.

Methods:
A literature review was carried out up to 2023 using various academic databases including
Google Scholar, Scopus, Web of Science, Science Direct, Research Gate, PubMed, and
Springer.

Results:
All of the plants discussed above share the same morphological characteristics, such as
the presence of spikelets, racemes, lemma, and glume. The GC-MS analysis revealed that
petroleum ether of U. distachya contains 15 phytoconstituents. Methanolic leave extract of U. distachya
disclosed 26 phytoconstituents by GC-MS analysis. The cold extraction of the whole plant
of U. distachya exhibited 18 compounds from GC-MS analysis. The root exudates of B. humidicola
contain phytoconstituents which are collected hydroponically from root exudates by semi-preparative
HPLC method. Methanolic extract of B. brizantha, A. hybridus, and P. maximum grains
were found in Caffeic acid, Ferulic acid, p-coumaric acid, p-hydroxybenzoic acid, and Protocatechuic
acid. D. sanguinalis contains three isolated phytoconstituents veratric acid, maltol, and (-)-
loliolide. Chemical analyses of D. insularis extract fractions by LC-MS revealed the presence of
the flavones tricin and diosmetin. Megathyrsus maximus, B. brizantha, Urochloa ramosa, and D.
abyssinica contain the presence of secondary phytoconstituents.

Conclusion:
This study found and investigated the phytopharmacological properties of Poaceae
species. The Poaceae family is rich in bioactive compounds which exhibit significant pharmacological
activity like antioxidant, anti-inflammatory, and antibacterial properties. These findings
show that Poaceae plants can be used to provide new drugs and natural health products. Further research
is needed to determine these compounds' precise biological activities and mechanisms of
action.
Cancer Trends in the U.S. (2001–2024): Progress and Persistent Challenges in Incidence and Mortality with Insights into Future Prevention and
Treatment
Authors: Hussain Afzal , Hussain Ashfaq 
Published: February 2025

Abstract:
This editorial explores the trends in incidence and mortality for cancer for the years
2001-2024, with special emphasis laid on some of the key public health as well as social implications.
It has been observed that new cases of cancer have been on the increase in the early years of
the 2000s, but the turnaround of the trend in mortality can be explained by major strides in the
field of diagnostics as well as treatment modalities, including immunotherapies and targeted therapies.
Even though the trend of increasing obesity-related cancers and persistent disparities in outcome
by race and socioeconomic status poses an ongoing challenge, projections for 2023 and
2024 show that the trend of incidence increases but stabilizes mortality. Such trends point to an
urgent need for an all-inclusive approach to prevention, early detection, and equitable access to
healthcare to prevent further burden of cancer on diverse populations.
Problemas psicológicos internalizados y externalizados en adultos jóvenes de Quito, Ecuador
Authors: Díaz-Mosquera Elena , Merlyn MarieFrance , Latorre Grace , Orbe Cristina 
Published: February 2025

Los problemas psicológicos involucran un amplio espectro de conductas internalizadas y externalizadas que afectan a la población. Los problemas internalizados aluden a alteraciones emocionales, mientras que los externalizados hacen referencia al ámbito conductual. En función de ello, el objetivo del presente estudio fue explorar el tipo de problemas psicológicos internalizados y externalizados que se presentan en mujeres y hombres universitarios que se encuentran cursando sus estudios en dos instituciones de educación superior de Quito, Ecuador. Participaron 553 universitarios, 42 % hombres y 58 % mujeres de 18 a 25 años (M = 20.79; DE = 2.07). Como instrumento, se utilizó la versión en español del Adult Self Report (ASR). Los resultados demostraron que los problemas internalizados reportados por las mujeres eran significativamente mayores que los de los varones y que los problemas externalizados se presentaban en ambos sexos, con conductas asociadas a estereotipos de género. En referencia al consumo de sustancias, no hubo diferencia en el reporte de ambos sexos en el uso de drogas, pero sí en cuanto a alcohol y tabaco, cuya incidencia fue mayor entre los hombres. Estos resultados demuestran la necesidad de implementar programas de promoción, prevención e intervención contextualizados al medio dirigidos a adultos jóvenes.
SOB O SIGNO DE EROS
Authors: Silva Zenil Josefa da 
Published: February 2025

Este estudo propõe fazer uma análise de trechos do romance Eu receberia as piores notícias de seus lindos lábios, de Marçal Aquino, seguindo a trajetória amorosa de Cauby e Lavínia, adotando a fundamentação teórica de Roland Barthes, em sua obra Fragmentos de um discurso amoroso (1981). Para esta finalidade, elegemos as seguintes figuras: o rapto, o encontro, a espera, e o corpo do outro; e, em seguida, selecionamos fragmentos do discurso do casal de enamorados, condizentes com as figuras barthesianas. Procuramos mesclar também a história de Eros e Psique ao discurso amoroso do casal romanesco. Para tanto, confrontamos a condição de sujeito/objeto de Cauby e Lavínia com o mito de Eros e Psique para apontar que Marçal Aquino estabelece uma inversão do sujeito/objeto, estilhaçando a estrutura do mito tradicional. Este estudo teve como base teórica Barthes (1981, 2015), Bataille (1987), Brandão (2012), Bulfinch (2002), e outros.
Accuracy of noninvasive screening exercise tests for detecting coronary artery disease in symptomatic patients with mitral valve prolapse: a systematic review
Authors: Sonaglioni Andrea , Nicolosi Gian Luigi , Bruno Antonino , Lombardo Michele 
Published: February 2025

Background
Since the 1970s, only a few studies have evaluated the accuracy of noninvasive screening exercise tests for detecting coronary artery disease (CAD) in symptomatic individuals with mitral valve prolapse (MVP). The present systematic review has been designed to summarize the main findings of these studies and to assess the overall pooled estimates of sensivity and specificity of exercise ECG, exercise myocardial perfusion scintigraphy (MPS) and exercise stress echocardiography (ESE) in diagnosing CAD among MVP individuals.

Methods
All studies examining the specificity and sensitivity of exercise ECG and/or exercise MPS and/or ESE in detecting obstructive CAD in symptomatic MVP patients, selected from PubMed and EMBASE databases, were included. There was no limitation of time period. The risk of bias was assessed by using the National Institutes of Health (NIH) Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies.

Results
The full texts of 11 studies with 840 MVP individuals were analyzed. True obstructive CAD was documented in 11.1% of MVP individuals (range 0–31.2%). When used in MVP patients with suspected CAD, exercise ECG, exercise MPS and ESE showed a pooled specificity of 61.9% (range 25–91.7%), 82.3% (range 25–100%) and 89% (range 80.5–97.6%), respectively, and a pooled sensitivity of 80% (range 50–100%), 96.7% (range 90–100%) and 91% (range 82–100%), respectively. The pooled positive predictive value was 33.2% (range 23.1–44.8%) for exercise ECG, 100% for exercise MPS and 80.2% (range 75.8–84.6%) for ESE, whereas the pooled negative predictive value was 80% (range 50–100%) for exercise ECG, 97% for exercise MPS and 99% (range 97.6–100%) for ESE.

Conclusion
ESE appears to be the first-choice screening method for CAD detection in symptomatic MVP individuals. It allows true CAD in symptomatic MVP individuals with false-positive exercise ECG results to be ruled out, without ionizing radiation exposure.
Transcatheter aortic valve implantation vs. surgery for failed bioprosthesis: a meta-analysis of over 20 000 patients
Authors: Comentale Giuseppe , Ahmadi-Hadad Armia , Moldon Harvey James , Carbone Andreina , Manzo Rachele , Franzone Anna , Piccolo Raffaele , Bossone Eduardo , Esposito Giovanni , Pilato Emanuele 
Published: February 2025

Objectives
Valve-in-valve transcatheter aortic valve implantation (ViV-TAVI) has gained popularity as a less invasive alternative to a redo surgical aortic valve replacement (redo-SAVR); which one is the preferred technique in these cases, however, remains a topic of debate, as the available data refer to retrospective studies with few patients or limited follow-up. The present metanalysis aimed to compare the short-term and long-term outcomes of the two techniques in the setting of a failed surgical bioprosthesis.

Methods
PubMed, MEDLINE, and Embase were searched on 10 November 2023 yielding 355 results (PROSPERO ID: CRD42023490612), of which 27 were suitable for meta-analysis. The primary outcomes were short-term and long-term all-causes and cardiovascular mortality. Logarithmic risk ratio (Log RR) and mean difference were used for categorical and continuous data, respectively.

Results
Both redo-SAVR and ViV-TAVI exhibited similar procedural and short-term mortality. However, ViV-TAVI demonstrated lower 1-year mortality [RR: 0.74, 95% confidence interval (CI) (0.57–0.96), P = 0.02], acute kidney injury (RR: 0.47, P < 0.001), bleeding (RR: 0.44, P < 0.001), stroke (RR: 0.70, P < 0.05), and new pacemaker implantation (RR: 0.69, P < 0.05). Conversely, redo-SAVR demonstrated more favorable mean postoperative aortic valve gradients [mean difference 2.59, 95% CI (0.86–4.31), P < 0.01].

Conclusion
Short-term mortality was similar between the groups, but ViV-TAVI showed better survival at 1 year as well as reduced rates of acute kidney injury, bleeding, stroke, and pacemaker implantation. However, redo-SAVR leads to a better hemodynamic profile. Even if collected data come from retrospective studies, the present results could help to guide the choice of the best approach case-by-case according to the patient's clinical profile.
Multiparty trust levels in evidence management: Ensuring tamper-proof chain of custody in blockchain.
Authors: Santos Nuno , Curado Joel , C. Ferreira Joao 
Published: February 2025

Abstract
International Criminal Courts (ICCs) are guarantors that justice can be achieved for the most egregious crimes against humanity and that surviving victims of those crimes can live with the assurance that the perpetrators will be held accountable for their actions. Those crimes are complex, sensitive and could be used as a weapon for an intervenient’ s own purpose and interests. As such, the credibility of these institutions is often attacked, and it is of critical importance that the process in which they pursue their mandate is rigorous and effective. Evidence sits at the core of the judicial process, and the participants rely on it to be authentic, integer and untampered with to ensure the fairness of the proceedings. Without enforcing powers, these ICCs could rely extensively on evidence provided by other parties to build a strong case from inception to the appeals stage. With the increased digitization of evidence, cyberthreats, size and complexity of evidence, traditional methods of managing the chain of custody are becoming vulnerable to the successful act of challenging the admissibility of evidence. Blockchain could be the answer for strengthening the chain of custody in evidence management, as this technology brings essential characteristics such as timestamping, authentication, immutability and trust among independent parties. This research conceives and designs a blockchainbased framework that maintains a tamperproof chain of custody and multilevel trust in evidence management. It ensures the authenticity and indisputability of evidence in judicial proceedings.
Blockchain and IoT in Smart Agriculture: Analysis, Opportunities, Challenges, and Future Research Directions
Authors: MARZOUGUI Fatma , ELLEUCH Mohamed , KHERALLAH Monji 
Published: February 2025

Abstract
Agricultural trends indicate a shift towards smart farming and the effective use of modern technologies and machine learning to manage time and resources while reducing crop losses and saving time and resources. These emerging technologies, including the Internet of Things (IoT) and Blockchain (BC), play an effective role in precision agriculture applications. They have made it possible to provide reliable services to guarantee and improve agricultural productivity. The entire agricultural system is improved through real-time monitoring of fields, soil fertility, irrigation techniques, temperature and humidity control, weather monitoring, detection of crop diseases, monitoring of agricultural products, etc. This article aims to present a literature review to examine the issues and challenges related to the blockchain approach associated with IoT applications. It also highlights key ways in which the blockchain approach can support the improvement of IoT systems. Additionally, it examines existing blockchain applications and platforms to provide a comprehensive summary of how the blockchain approach cooperates with the IoT paradigm.
Decentralization and Federated Approach for Personal Data Protection and Privacy Control
Authors: Singh Suyogita , Verma Satya Bhushan , Gupta Bineet Kumar , Agrawal Anamika 
Published: February 2025

Abstract
As the digital ecosystem evolves, personal data protection and privacy control have become paramount concerns. Traditional centralized approaches to data management and privacy often pose risks to individuals’ data security and privacy. This research paper explores the potential of decentralization and federated approaches as innovative solutions for enhancing personal data protection and privacy control. By distributing data across multiple entities and empowering individuals with control over their data, decentralized and federated models offer increased security, privacy, and data autonomy. This paper investigates the benefits, challenges, and future prospects of decentralized and federated approaches in personal data protection and privacy control.
Prevalence of Services Provided by the Mobile Emergency Care Service in the City of Paraiso do Tocantins-TO
Authors: Brito Andreia Kassia Lemos de , Holanda Franciscode Sousa , Coelho Lukas Oliveira , Almeida Márcio Araújo de , Paiva Maykon Jhuly Martins de , Lima Pedro Lucas Enomoto , Diogo Renata Ferreira , Nunes Rodrigo Disconzi , Herrera Sávia Denise Silva Carlotto , Souza Thiago Santos 
Published: February 2025

Objective: This study analyzes the Mobile Emergency Care Service (SAMU) in Paraíso do Tocantins, identifying occurrence patterns, victim profiles, response times, and geographical distribution of services. The objective is to understand emergency demand dynamics, optimize resources, improve triage and team allocation, and provide insights for enhancing public policies in emergency care.

Method: This is a cross-sectional and descriptive study based on the analysis of service records collected between May and September 2024. Data were extracted from the incident management system, organized in spreadsheets, and statistically analyzed to identify patterns and trends. Variables considered include the type of incident, victim profiles, response time, and geographical distribution.

Results and Discussion: Findings indicate a predominance of clinical and psychiatric cases, over 90% efficiency in response time, and a concentration of services in specific areas. The discussion highlights the necessary infrastructure improvements for better triage and real-time monitoring, along with potential enhancements in case management.

Research Implications: The study emphasizes the need for resource optimization, particularly during highdemand months, and the importance of preventive actions targeting adult men and the elderly. It also highlights the need for logistical strategies in regions with a higher number of emergency calls.
Originality/Value: This study provides an updated analysis of SAMU emergency services, reinforcing the importance of public policies to improve infrastructure and service efficiency.
Media and Knowledge in the Third Sector: a Framework for Consolidating Social Initiatives
Authors: Pinto Larissa Gaspar Coelho , Baldessar Maria José 
Published: February 2025

Objective: The article explores how Civil Society Organizations (CSOs) can use Information and Communication Technologies (ICT) to enhance communication strategies and resource management, strengthening financial sustainability. Additionally, it proposes a media lab-inspired framework for innovation in the Third Sector.

Theoretical Framework: The research is based on the historical and conceptual evolution of CSOs and media labs. CSOs operate in response to limitations of the State and private market, facing challenges in fundraising and governance. Media labs, in turn, are spaces for technological experimentation and collaborative innovation.

Method: A qualitative approach includes a literature review and secondary data analysis from research on CSOs and media labs. The analysis considers technological infrastructure, capacity building, and stakeholder engagement.

Results and Discussion: Findings indicate that CSOs still face challenges in resource management and communication with investors. Adopting media lab practices can enhance their innovation, fundraising, and social impact.

Research Implications: The study suggests investments in digital infrastructure and training, highlighting the importance of collaboration between CSOs, the State, and the market to strengthen the Third Sector.

Originality/Value: This study proposes an innovative framework by integrating CSOs and media labs, expanding the understanding of digital transformation and financial sustainability in the Third Sector.
TRADITIONAL STEREOTYPES OF SPEECH ETIQUETTE IN THE FRAMEWORK OF THE UKRAINIAN OUTLOOK
Authors: Tymkova Valentina , Мanzhos Elvira 
Published: February 2025

У статті розкрито зміст та сутність поняття “мовленнєвий етикет”, його основні характеристики, зв’язок з поняттям ввічливості, культурно-національною специфікою і параметрами дискурсної варіативності, що визначають процес мовленнєвої взаємодії між комунікантами.
Зазначено, що український мовленнєвий етикет – явище прогресивне й суто національне, бо належить рідній (материнській) мові та відображає національний характер українця, його ментальність – склад розуму, самобутній спосіб мислення та світосприймання. Це категорія загалом стала. Однак прогрес суспільства вносить у нього, відповідно до конкретних практичних потреб, певні корективи, спрямовані на подальше вдосконалення й розвиток. Скажімо, поява радіо, телевізора й телефону зумовила потребу у відповідному для них етикеті спілкування. І все ж основа мовленнєвого етикету незмінна – утвердження коректності й доброзичливих стосунків між людьми.
Зауважено, що український мовленнєвий етикет передбачає властиві українцям національно-специфічні правила мовленнєвої поведінки, утілені в системі стійких формул і виразів для прийнятих і запропонованих суспільством ситуацій чемного контакту зі співбесідником. До таких ситуацій належать: звертання до співрозмовника та привернення його уваги, вітання, знайомство, вдячність, пробачення, прощання тощо.
У висновках зазначено, що важливо добре засвоїти чинники, які впливають на вибір словесної формули в конкретній комунікативній ситуації: фактор адресата (його вік, стать тощо), комунікативні умови (місце, час, тривалість спілкування), характер взаємин між співрозмовниками тощо.