bluuebunny/crossref_metadata_2025_split huggingface dataset:
MANAJEMEN PROGRAM PERENCANAAN, PELAKSANAAN, DAN EVALUASI MUNADHARAH 'ILMIYAH PEKAN ARABI DI UNIVERSITAS NEGERI MALANG DI MASA PANDEMI
Authors: Aini Dalilan , Islami Muhammad Nahidh , Rosyida Eva Famila , Arifa Zakiyah , Machmudah Umi 
Published: January 2022

Abstrak
Tujuan dari penelitian ini adalah mendeskripsikan manajemen perencanaan, pelaksanaan dan evaluasi program munadharah ‘ilmiyah Pekan Arabi di Universitas Negeri Malang di masa pandemi. Jenis penelitian dalam penelitian ialah jenis penelitian kualitatif metode deskriptif. Teknik pengumpulan data yaitu menggunakan metode wawancara dan dokumentasi. Teknik analisis data, peneliti menggunakan teori Miles dan Huberman, yaitu mengumpulkan data dari hasil wawancara dan dokumentasi, reduksi data, display data, dan conclusion Drawing. Hasil penelitian dan pembahasan penelitian ini terdiri dari 1) Perencanaan, terdapat 3 hal penting yang harus dipenuhi dalam perencanaan program munadharah ‘ilmiyah. Pertama, model interactive approach. Kedua, dalam ruang lingkup program ini terdapat 3 dimensi. Ketiga, proses perencanaan program ini melalui tahapan-tahapan yang sistematis. 2) Pelaksanaan, terdapat 3 hal penting yang terdapat dalam penyusunan program Munadharah ‘ilmiyah. Pertama, tahap pemula, kedua, tahap pelaksanaan program, ketiga, tahap penilaian setelah diadakannya program munadharah ‘ilmiyah. 3) Evaluasi terdapat 2 hal penting yang harus dipenuhi dalam evaluasi program munadharah ‘ilmiyah, yaitu evaluasi monitoring dan evaluasi komprehensif.
Kata Kunci: Evaluasi, Munadharah Ilmiyah, Manajemen Program
The mental load in separated families
Authors: Luthra Renee , Haux Tina 
Published: January 2022

Objective: This paper asks how evolving contact and gendered working lives, gendered identities, and conflict and parental relationships influence cognitive labour in separated families.
Background: The fact that the often-invisible work of planning, researching, and executing decisions concerning children and household maintenance is borne by women/mothers, receives growing research attention, yet, the bulk of this research focuses on the gendered division of the mental load in intact families. Given the high prevalence of separated families with high levels of father contact, more work is needed to understand how cognitive labour is divided by parents residing in separate households.
Method: This paper draws on 31 semi-structured interviews of separated parents, including 7 former couples. Interviews were sampled from a nationally representative longitudinal survey, Understanding Society, professionally transcribed and thematically analysed with Nvivo.
Results: Analysing the interviews reveals both continuity and change in the division of the mental load following separation. For some families, gendered identities and working lives continue to justify an unequal division of the mental load, even when children spend large amounts of time solely with fathers. In others, conflict can reduce communication between parents, either increasing fathers cognitive labour through parallel parenting or decreasing it when fathers are excluded from decision-making altogether. Finally, separation can present a turning point where working lives and identities are re-evaluated, and the mental load can be negotiated anew.
Conclusion: We provide new evidence that the mental load remains gendered even among those practicing a relatively "modern" family form of shared care post-separation, while highlighting possibilities for variation and change.
Efficacy and Applications of Artificial Intelligence and Machine Learning Analyses in Total Joint Arthroplasty
Authors: Polce Evan M. , Kunze Kyle N. , Dooley Matthew S. , Piuzzi Nicolas S. , Boettner Friedrich , Sculco Peter K. 
Published: January 2022

Update
This article was updated on August 23, 2022. Specifically, a new table (Table S4) was added to the Appendix.
An erratum has been published: J Bone Joint Surg Am. 2022 Oct 5;104(19):e87.

Background:
There has been a considerable increase in total joint arthroplasty (TJA) research using machine learning (ML). Therefore, the purposes of this study were to synthesize the applications and efficacies of ML reported in the TJA literature, and to assess the methodological quality of these studies.

Methods:
PubMed, OVID/MEDLINE, and Cochrane libraries were queried in January 2021 for articles regarding the use of ML in TJA. Study demographics, topic, primary and secondary outcomes, ML model development and testing, and model presentation and validation were recorded. The TRIPOD (Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis) guidelines were used to assess the methodological quality.

Results:
Fifty-five studies were identified: 31 investigated clinical outcomes and resource utilization; 11, activity and motion surveillance; 10, imaging detection; and 3, natural language processing. For studies reporting the area under the receiver operating characteristic curve (AUC), the median AUC (and range) was 0.80 (0.60 to 0.97) among 26 clinical outcome studies, 0.99 (0.83 to 1.00) among 6 imaging-based studies, and 0.88 (0.76 to 0.98) among 3 activity and motion surveillance studies. Twelve studies compared ML to logistic regression, with 9 (75%) reporting that ML was superior. The average number of TRIPOD guidelines met was 11.5 (range: 5 to 18), with 38 (69%) meeting greater than half of the criteria. Presentation and explanation of the full model for individual predictions and assessments of model calibration were poorly reported (<30%).

Conclusions:
The performance of ML models was good to excellent when applied to a wide variety of clinically relevant outcomes in TJA. However, reporting of certain key methodological and model presentation criteria was inadequate. Despite the recent surge in TJA literature utilizing ML, the lack of consistent adherence to reporting guidelines needs to be addressed to bridge the gap between model development and clinical implementation.
Detection of Breast Cancer Related Gene Polymorphisms By a New Modified PCR-RAPD-PCR Technique
Authors: Allami Zainab Zamil gataa , Dragh Maytham A 
Published: January 2022

Abstract
Breast cancer is one of the most aggressive cancers with high estimated mortality worldwide; many studies around the world have involved polymorphisms in drug resistance genes, tumor suppressor genes, estrogen receptor genes, and regulatory genes related to the development and prognosis of breast cancers. It is worth noting that this study was the first to include these genes as PCR templates to determine the relationship between their polymorphisms and breast cancer incidence using RAPD of amplified genes. The study was designed first to evaluate the association of ABCG2, ABCB1 and BRCA1 gene polymorphisms in addition to miRNA-152 and ER-a using the RAPD technique with breast cancer incidence in women in Maysan, Province and then to employ those genes in the future as biomarkers in breast cancer prediction and diagnosis. This study included 100 patients with breast cancer and 30 healthy control women, and then all samples were amplified by conventional PCR with specific F and R primers for ABCG2, ABCB1, BRCA1, ER-α, and miRNA-152 genes. Then, the best PCR product (20) was chosen as the template for the RAPD technique. The results revealed that all RAPD primers showed polymorphisms with higher values in patient samples, and revealed several mutations in patient samples. Our study proved the relationship between genetic polymorphisms of breast cancer related genes and a higher incidence of cancer. The results of the statistical analysis by using Chi-square showed that there were no significant differences in the types of bands of the ABCG2, ABCB1, BRCA1 between the patient sample and the control sample, at the probability level of P >0.05, and significant differences in the types of bands of the ER-α, and mi-RNA 152 between the patient sample and the control sample, at the probability level of P <0.05. The current study recommends employing these results for future prediction and diagnosis of breast cancers.
Facile synthesis of CoOOH@MXene to Activate Peroxymonosulfate for Efficient Degradation of Sulfamethoxazole: Performance and Mechanism Investigation
Authors: Xia Xinjing , Deng Lin , Yang Lingfang , Shi Zhou 
Published: January 2022

Abstract
Using MXene as substrate, CoOOH@MXene with different mass content of CoOOH were prepared and used to active PMS for the sulfamethoxazole (SMX) degradation. The samples characterizations demonstrated the successful preparation of CoOOH@MXene. CoOOH@MXene possessed much higher BET surface area (183.82 m2/g) than CoOOH (85.36 m2/g) and MXene (6.89 m2/g) due to the good dispersibility of CoOOH particles on MXene. Due to its large surface area, 1.3CoOOH@MXene displayed the best catalytic performance for the degradation of SMX. With 0.2 g/L of 1.3CoOOH@MXene and 0.5 mM of PMS, 20 μM of SMX was completely eliminated in 10 min. The degradation followed pseudo-first-order kinetic model well, with rate constants of 0.33 min-1 and 0.054 min-1 for 1.3CoOOH@MXene and CoOOH. Influencing factors of initial pH, catalyst dosage, PMS concentration, SMX concentration and co-existing anions on SMX degradation were assessed systematically. Recycling tests verified the excellent reusability and stability of the catalyst. Quenching experiments and electron paramagnetic resonance analysis substantiated that 1O2 played a leading role. Moreover, the intermediates were identified, and degradation pathways and activation mechanism of CoOOH@MXene for PMS were proposed. This work may highlight the application of MXene with transition metals in PMS activation.
The Effect of Writing Therapy Using Two Methods of Expressive Writing and Daily Activity Writing on Stress, Anxiety and Depression in Primiparous Pregnant Women; A Randomized Clinical Trial
Authors: Mirmolaei Seyedeh Tahereh , khalili fatemeh , ranjbar hadi 
Published: January 2022

Abstract
Introduction: Depression, anxiety and stress during pregnancy are associated with detrimental effects on maternal and child health. Writing is a cheap and non-invasive treatment that can improve mental health. This study was aimed to compare the effect of writing in two ways of expressive writing and daily activity writing on stress, anxiety, and depression in pregnant women.Methods: This clinical trial study was performed on 102 primiparous women with a gestational age of 25-28 weeks referred to the of South Health center of Tehran University of Medical Sciences. The samples were divided into two intervention groups and one control group by block randomization sampling method. Research instruments included demographic questionnaires, Beck Depression Inventory, and Depression Anxiety Stress Scale (Dass21). In the expressive writing group, women were asked to write their deepest feelings. In the daily activity writing group, daily activities were written without involving feelings and emotions. The control group received routine prenatal care. All three groups completed the DASS21 questionnaire before the intervention, four and eight weeks after the intervention. Data were analyzed using SPSS V21 software and ANOVA, Chi-square, and Fisher tests.Results: The variables of stress, anxiety, and depression were not statistically significant before the intervention in all 3 groups. The mean score of stress, anxiety, and depression in the two groups of expressive writing and daily activity writing was statistically significantly lower than the control group 4 weeks and 8 weeks after the intervention.Conclusion: According to the results of this study, writing can be recommended as a simple and low-cost method in reducing anxiety, stress, and depression in pregnant women during prenatal care.Trial registration: IRCT20170815035722N3. Registration date: 18-05-2019
Nodal Positive Breast Cancer and Its Regional Lymph Node Involvement
Authors: Männle Heidrun , Frank Matthias , Momm Felix , Siebers Jan Willem 
Published: January 2022

Abstract
Purpose: In breast cancer, the lymph node status is of prognostic importance. This study shows the distribution of lymph nodes metastases of node-positive breast cancer patients. Risk factors for lymph node metastases are described.Methods: 2095 patients with primary breast cancer were analyzed. Analysis included descriptive and statistical analysis.Results: The nodal stage was positive in 39.4% of all patients and negative in 60.6%. If the nodal stage was positive, only 1 lymph node was involved in 36% of the patients; more than 1 lymph node was involved in 64% of the patients. With an increasing number of lymph node metastases in level I, the probability of an involvement in level III also increases (F 437.845, p = .000). Other indicators are evidence of hemangiosis (F 247.728, p = .000) or lymphangiosis (F 167.368, P = .000). Despite <10 affected lymph nodes, 3.4% of the patients had nodal stage N3 due to level III involvement.Conclusion: Even with only a small number of lymph node metastases in level I higher lymphatic stations are often affected. The data cannot lead to a decision regarding an operation or radiation indication, but they can better substantiate the risk for certain therapy decisions.
Artificial Consortia of Bacillus Amyloliquefaciens HM618 and Bacillus Subtilis for Utilizing Food Waste to Synthetize Iturin A
Authors: Miao Chang-Hao , Wang Xiao-Feng , Qiao Bin , Xu Qiu-Man , Cao Chun-Yang , Cheng Jing Sheng 
Published: January 2022

Abstract
Food waste is a kind of biodegradable organic resource. It can be degraded into the small energy molecules for providing precursors to synthetize iturin A, which is a kind of lipopeptide with broad-spectrum antifungal activity for widely applying in biocontrol of the plant disease. However, the lower yield and higher cost during producing iturin A limit its application. In this study, the recombinants of Bacillus subtilis producing lipase and amylase were constructed to utilize food waste for producing iturin A under the consortium with Bacillus amyloliquefaciens HM618 produced iturin A and the engineering B. subtilis. The results showed that recombinant strain WB-A13 had the highest amylase activity of 23406.4 U/mL, and the lipase activity of WB-L01 was 57.5 U/mL. When HM618 was co-cultured with the engineering strain WB800N-AmyE or WB800N-Lip, the relatively highest yield of iturin A reached to 7.66 mg/L in co-cultured fermentation of consortium with HM618 and WB-A14, which was increased 32.9% compared to that of HM618 under pure culture. Under three-strains consortium containing HM618, WB-L02 and WB-A14, the yield of iturin A reached 8.13 mg/L, which was 38.8% higher than the control when the initial size OD600 of above three strains was 0.2, 0.15 and 0.15 respectively. Taken together, artificial consortium of B. amyloliquefaciens and the recombinant B. subtilis can better bioconvert food waste into iturin A, which provides a new strategy for the high-value utilization of food waste.
Effect of behavior change communication through health development army on optimal nutrition and health practice of pregnant women in Ambo district, Ethiopia: a cluster randomized controlled community trial
Authors: Gebremichael Mitsiwat Abebe , Lema Tefera Belachew 
Published: January 2022

Abstract
Background: Pregnancy is such a critical phase in a woman's life, when mother's nutritional and health status at conception and throughout pregnancy plays a key role in determining her health and well-being, as well as that of her child. Therefore, the objective of the study was to investigate the effect of Behavior Change and Communication (BCC) through women development Army on optimal nutrition and health practices of pregnant women.Methods: A cluster randomized controlled community trial (CRCCT) with baseline and end line measurements using quantitative data collection methods was conducted in Ambo district among 750 pregnant women aged 18-49 years (375 of control and 375 of intervention groups). Of which endpoint data were collected from 372 and 372 pregnant women in the intervention and control clusters, respectively. Pretested semi structured questionnaire was used to collect data. The intervention was started in July, 2018 and data collection for end line was started in October, 2018.Descriptive statistics, chi-square test, bivariate and lastly multivariate binary logistic regressions analysis was used to control confounders. Statistical analyses were conducted primarily on intention-to-treat (ITT) basis and p value <0.05 was used to declare statistical significance.Result: The overall optimal nutrition and health practice among intervention group were 62.6%, while among control group were 39.0% (p<0.0001).Being in the intervention group, educational status, estimated time to reach health institution, knowledge about nutrition and health were found significantly associated with optimal nutrition and health practices in multivariable binary logistic regression analysis (p<0.05).Conclusions: Behavior change communication (BCC) through women development army is effective in improving optimal nutrition and health practices of pregnant women. Therefore, to improve optimal nutrition and health practices of pregnant women, BCC through health development Army is recommended.Trial registration: Pan African Clinical Trial Registry: unique identification number for the registry is (PACTR201805003366358).
Endothelial Leakiness Induced by Amyloid Protein Aggregation
Authors: Li Yuhuan , Ni Nengyi , Lee Myeongsang , Wei Wei , Andrikopoulos Nikolaos , Kakinen Aleksandr , Davis Thomas P , Song Yang , Ding Feng , Leong David , Ke Pu Chun 
Published: January 2022

Abstract
Alzheimer’s disease (AD) is a major cause of dementia debilitating the global ageing population. Current understanding of the AD pathophysiology implicates the aggregation of amyloid beta (Aβ) as causative to neurodegeneration, with tauopathies and neuroinflammation considered as other major culprits. Curiously, vascular endothelial barrier dysfunction is strongly associated with Aβ deposition and 80-90% AD subjects also experience cerebral amyloid angiopathy. Here we show amyloid proteins-induced endothelial leakiness (APEL) in human microvascular endothelial monolayers as well as in mouse cerebral vasculature. Using signaling pathway assays and discrete molecular dynamics, we revealed that the angiopathy first arose from a disruption to vascular endothelial (VE)-cadherin junctions exposed to the nanoparticulates of Aβ oligomers and seeds, preceding the earlier implicated proinflammatory and pro-oxidative stressors to endothelial leakiness. These findings are analogous to nanomaterials-induced endothelial leakiness (NanoEL), a major phenomenon in nanomedicine depicting the paracellular transport of anionic inorganic nanoparticles in the vasculature. As APEL also occurred with the anionic seeds of pathogenic alpha synuclein and functional FapC bacterial amyloid, this study projects a general new paradigm for elucidating the vascular permeation, systemic spread, and cross-seeding of amyloid proteins that underlie the pathogeneses of AD, Parkinson’s, as well as a range of amyloid diseases.
Bioaccumulation of Metals by Algae From Acid Mine Drainage: A Case Study of Frongoch Mine (United Kingdom)
Authors: Du Tianhao , Bogush Anna , Edwards Paul , Stanley Peter , Lombardi Ana T. , Campos Luiza C. 
Published: January 2022

Abstract
Acid mine drainage (AMD) contains high concentrations of potentially toxic metals, which contaminates receiving watercourse. In Frongoch Mine (United Kingdom), it is unclear the distribution of metals on indigenous algae and whether these species of algae can accumulate metals. This study investigated the role of indigenous algae for metals removal from AMD and examined if metals can be adsorbed on the surface or/and bioaccumulated in algae. Sequential extraction procedure was applied for algae samples collected from AMD water to identify the forms in which metals are found in algae. Concentrations of Fe, Pb, Zn, Cu, and Cd in algae were determined. AMD samples were found to have pH 3.5 to 6.9 and high concentrations of Zn (351 mg/L) and Pb (4.22 mg/L) that exceeded water quality standards. Algae Ulothrix sp. and Oedogonium sp. were the two main species in the Frongoch AMDs. Concentrations of metals in algae ranged from 0.007 to 51 mg/g and the bioconcentration factor of metals decreased in the following order: Fe>>Pb>>Cu>Cd>Zn. Zn, Cu and Cd were found to be adsorbed on algae surface and bioaccumulated in the algae while Pb and Fe mainly bioaccumulated in the algae. Indigenous algae can be considered as a biogeochemical barrier to bioaccumulate algae and as a bioremediation method. Also, indigenous algae could be used as a bioindicator for the assessment of water pollution at Frongoch Mine and other metal mines.
Examining the Short-Term Effect of Moderate Level Air Pollution on Multi-Department Outpatient Visits in Xi’an, China
Authors: Wang Qingnan , Chen Zhuo , Huang Wei , Kou Bo , Li Jingwei 
Published: January 2022

Abstract
Objective: There is limited evidence concerning the association between air pollution and outpatient visits in moderately polluted areas. This paper investigates the effects of moderate level ambient air pollution on the number of outpatient visits associated with five categories of medical conditions. Methods: We analyzed a total of 1,340,791 outpatient visits for five medical departments (pediatrics, respiratory, ENT, cardiovascular, and orthopedics) in Xi’an from 2016 to 2018. A distributed non-linear model was used to analyze the associations and was fitted and stratified by age and season. Results: We found 𝑆𝑂2 had the largest effect on pediatrics visits (RR=1.105 (1.090, 1.121)). The relationships among 𝑃𝑀2.5 and 𝑂3 and ENT were more statistically significant in a heating season than those in a non-heating season. Meanwhile, 𝑃𝑀2.5, 𝑃𝑀10, and 𝑆𝑂2 had bigger impacts on ENT visits for people under 50 years. The results showed a strong association between 𝑂3 and cardiovascular outpatient visits in a non-heating season (RR=1.026 (1.020,1.032)). The results also showed that 𝑃𝑀10 was not significantly associated with respiratory outpatient visits, and every 10 𝜇𝑔/𝑚3 increase of 𝑆𝑂2 reduced the number of respiratory outpatient visits by 3%. We found 𝑃𝑀2.5 and 𝑁𝑂2 were significantly related to orthopedic outpatient visits for people under 60.Conclusion: Our findings indicated short-term exposure to air pollutants had varying associations with outpatient visits to four medical departments. We also proposed a new set of air pollution thresholds, which could help hospitals optimize outpatient resource allocation and the government determine appropriate air quality standards.