bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technical Skill Assessment in Minimally Invasive Surgery Using Artificial Intelligence: A Systematic Review
Authors: Pedrett Romina , Mascagni Pietro , Beldi Guido , Padoy Nicolas , Lavanchy Joël L. 
Published: November 2022

AbstractObjectiveTo review artificial intelligence (AI) based applications for the assessment of technical skills in minimally invasive surgery.BackgroundAs technical skill assessment in surgery relies on expert opinion, it is time-consuming, costly, and often lacks objectivity. Analysis of routinely generated data by AI methods has the potential for automatic technical skill assessment in minimally invasive surgery.MethodsA systematic search of Medline, Embase, Web of Science and IEEE Xplore was performed to identify original articles reporting the use of AI in the assessment of technical skill in minimally invasive surgery. Risk of bias (RoB) and quality of included studies were analyzed according to Quality Assessment of Diagnostic Accuracy Studies criteria and the modified Joanna Briggs Institute checklists, respectively. Findings were reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.ResultsIn total, 1467 articles were identified, 37 articles met eligibility criteria and were analyzed. Motion data extracted from surgical videos (49%) or kinematic data from robotic systems or sensors (46%) were the most frequent input data for AI. Most studies used deep learning (73%) and predicted technical skills using an ordinal assessment scale (73%) with good accuracies in simulated settings. However, all proposed models were in development stage, only 8% were externally validated and 16% showed a low RoB.ConclusionAI is promising to automate technical skill assessment in minimally invasive surgery. However, models should be benchmarked on representative datasets using predefined performance metrics and tested in clinical implementation studies.Mini AbstractTechnical skill assessment in minimally invasive surgery is time consuming and costly. Artificial intelligence is a promising technology to facilitate and automate technical skill assessment. Therefore, this article systematically reviews artificial intelligence applications for the assessment of technical skills in minimally invasive surgery.
Coronary artery disease and prostate cancer share a common genetic risk mediated through Lipoprotein(a)
Authors: Baylis Richard A. , Wang Fudi , Gao Hua , Bell Caitlin , Luo Lingfeng , Nead Kevin T. , Neilan Tomas G. , Ross Elsie Gyang , Klarin Derek , Leeper Nicholas J. 
Published: November 2022

Brief unreferenced abstractThe genetics underlying cancer and cardiovascular disease have been studied for decades. However, despite sharing numerous risk factors and pathologic features, the contribution of shared genetics in these diseases remains poorly defined. Our study sought to identify common genetic factors between these two diseases. We found a unique relationship between coronary artery disease and prostate cancer that appears to be mediated through germline genetic variation in LPA.
An investigation of patent-intensive industries and government development strategy: evidence from China
Authors: Chang Xuhua , Jiang Nan , Liu Hairui 
Published: November 2022

Purpose
The number of patents in China has grown rapidly in recent years. The purpose of this paper is to investigate how patents impact economic development in China.

Design/methodology/approach
This paper developed an empirical model by using panel data of 42 China's patent-intensive industries to investigate the economic contribution made by Chinese patent-intensive manufacturing industries.

Findings
This paper found that the intensity of valid patents is strongly positively related to economic growth. The intensity of yearly added patents presented an inverse U-shaped and a U-shaped curve with the economy made by China’s patent-intensive industries. The correlativity mainly depended on whether the patent intensity converges near the economic indicators. Meanwhile, from the perspective of input–output efficiency, for China’s patent-intensive industries, R&D institutes were overinvested, followed by R&D intensity and R&D staff.

Originality/value
Investigating patent influence on economic development is quite complex research. Existing studies have mainly focused on patent protection in legal systems, but have not provided a definitive answer to what the real influence is. This study sought to narrow this gap from the patent economy perspective.
Cross-border acquisitions and technological spillover: evidence from European regional clusters
Authors: Sabbadin Elisa , De Noni Ivan , Belussi Fiorenza 
Published: November 2022

PurposeRelying on mergers and acquisition transaction-level data set and adopting a more region-specific approach with a focus on industry-region pairs, this paper aims to examine how cross-border acquisitions (CBAs) have an effect, in terms of technological spillover and collaboration, on European regional clusters.Design/methodology/approachAdopting an industry-region pair approach, this study is based on a quantitative analysis of regional clusters belonging to 262 European regions and 25 patenting industries. Different thresholds of industrial specialization are used to identify clustering industries within a region. Invention performance at the regional cluster level is defined through two sets of different measurements to assess the impact of CBAs on invention quantity performance and internal and external technological collaboration.FindingsThe results reveal that CBAs have a positive and significant impact on the number of patents as well as the number of internal and external technological collaborations and that this effect is persistent over time. Furthermore, through exploring the interindustry technological spillover effect of CBAs registered in the same region of a cluster but outside the cluster itself, the authors found that CBAs in a regional cluster are inclined to produce technological spillovers within the cluster but no significant effects in the other industries of the region.Originality/valueThis paper is an attempt to empirically explore CBAs and technological spillover in European regional clusters. Therefore, it contributes to the debate, thanks to the use of an industry-region pair approach.
Consumer attitudes toward ordering from cloud kitchens: a gender and marital status perspective
Authors: Pookulangara Sanjukta , Wen Han , Bharath Josiam 
Published: November 2022

Purpose
The purpose of this study was to examine consumer’s perceptions of cloud kitchens, including the influence of perceived innovativeness (PI), utility motivations (price and food varieties), and food safety risk perceptions (FSRP) on trust; the impact of hedonic motivations and trust on attitude; and the moderating effect of FSRP on the relationship between utility motivations (food varieties) and trust. The relationships were examined with respect to gender and marital status.

Design/methodology/approach
The Theory of Consumption Value served as the theoretical underpinning of this study. Data was collected with an online survey (n = 316) using the Qualtrics panel. The partial least squares–structural equation modeling method was used to analyze the survey data.

Findings
PI, utilitarian motivations (price) and hedonic motivations (food varieties) positively influenced trust, whereas trust positively influenced attitude. FSRP negatively impacted trust and moderated the relationship between utility motivations (food varieties) and trust. Hedonic motivations positively influenced consumers’ attitudes. Multi-group analyses highlighted the differences attributed to gender and marital status.

Research limitations/implications
PI and utility motivations influenced trust, supporting the notion that consumers are open to new and convenient ways to order food. Additionally, the negative influence of FSRP on trust and its moderating role on the path between food varieties and trust highlights the importance of FSRP on food consumption. Finally, this study provided insight into the influence of gender and marital status on perceptions of ordering from cloud kitchens.

Originality/value
The cloud kitchen business model is undergoing exponential growth, and this study provides an understanding of cloud kitchens from a consumer’s perspective.
Resourcing, sensemaking and legitimizing: blockchain technology-enhanced market practices
Authors: Russo-Spena Tiziana , Mele Cristina , Pels Jaqueline 
Published: November 2022

Purpose
This paper aims to focus on how the use of new technologies disrupts markets. To date, marketing literature has lacked studies investigating the link between market practices and new technologies. The study adopts the blockchain technology (BcT) context to elicit novel technology-enhanced market practices.

Design/methodology/approach
The authors adopt a qualitative multimethod research design to engage in interpretative theorizing. They investigated 77 companies and used the Gioia method for the data coding and analysis.

Findings
The study of the adoption of blockchain prompts three technology-enhanced market practices. The latter offers new ways of resourcing by removing constraints and expanding actors’ network and knowledge to integrate resources; sensemaking by expressing new language and assigning novel meaning to represent markets; and legitimizing, by structuring new rules and trusting new mechanisms to institutionalize markets.

Research limitations/implications
The technology-enhanced market practices are distinct from extant market practices as well as related, thus, enriching and complementing them. Therefore, this work expands the understanding of the mechanisms of how markets work.

Originality/value
This study is the first, to the best of the authors’ knowledge, to focus on how BcT features affect market practices. BcT market practices entail how actors perform, share and interpret symbols and objects and set rules for how markets should work.
Development of a reporter gene assay for antibody dependent cellular cytotoxicity activity determination of anti‐rabies virus glycoprotein antibodies
Authors: Wang Wenbo , Yu Chuanfei , Cui Yongfei , Liu Chunyu , Yang Yalan , Xu Gangling , Wu Gang , Du Jialiang , Fu Zhihao , Guo Luyong , Long Caifeng , Xia Xijie , Li Yuhua , Wang Lan , Wang Youchun 
Published: November 2022

AbstractRabies is a viral disease that is nearly 100% fatal once clinical signs and symptoms develop. Post‐exposure prophylaxis can efficiently prevent rabies, and antibody (Ab) induction by vaccination or passive immunization of human rabies immunoglobulin (HRIG) or monoclonal antibodies (mAbs) play an integral role in prevention against rabies. In addition to their capacity to neutralize viruses, antibodies exert their antiviral effects by antibody‐dependent cellular cytotoxicity (ADCC), which plays an important role in antiviral immunity and clearance of viral infections. For antibodies against rabies virus (RABV), evaluation of ADCC activity was neglected. Here, we developed a robust cell‐based reporter gene assay (RGA) for the determination of the ADCC activity of anti‐RABV antibodies using CVS‐N2c‐293 cells, which stably express the glycoprotein (G) of RABV strain CVS‐N2c as target cells, and Jurkat cells, which stably express FcγRⅢa and nuclear factor of activated T cells (NFAT) reporter gene as effector cells (Jurkat/NFAT‐luc/FcγRⅢa cells). The experimental parameters were carefully optimized, and the established ADCC assay was systematically validated according to the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) Q2 guideline. We also evaluated the ADCC activity of anti‐RABV antibodies, including mAbs, HRIG, and vaccine induced antisera, and found that all test antibodies exhibited ADCC activity with varied strengths. The established RGA provides a novel method for evaluating the ADCC of anti‐RABV antibodies.
Imagining and assessing future risks: A dynamic scenario‐based social vulnerability analysis framework for disaster planning and response
Authors: Orru Kati , Klaos Margo , Nero Kristi , Gabel Friedrich , Hansson Sten , Nævestad Tor‐Olav 
Published: November 2022

AbstractWhile social vulnerability assessments should play a crucial part in disaster management, there is a lack of assessment tools that retain sensitivity to the situation‐specific dynamics of vulnerabilities emerging in particular hazard scenarios. We developed a novel scenario‐based vulnerability assessment framework together with practitioners in crisis management and assessed the suitability of its components in three past crises and their scenario‐based derivations: a large‐scale power outage, the COVID‐19 pandemic, and a cyber‐attack. Rather than deterministically concluding about vulnerability based on prefixed factors, the framework guides relevant stakeholders to systematically think through categories of vulnerability pertinent to a scenario. We used a table‐top exercise, interviews, and focus groups to demonstrate how the framework broadens the crisis managers’ understanding of the scope of factors that may cause vulnerability, the related sources of information and enables to identify individuals burdened by certain vulnerability mixes. The new framework could be applied to different types of crises to enhance preparedness, demand‐driven relief and rescue during critical events.
Recognising risk, influencing reality and mental healthcare in a regional emergency department
Authors: Craythorn Scott , O'Sullivan Margaret 
Published: November 2022

AbstractMental health presentations to EDs continue to rise with associated challenges increasingly understood and well documented. Despite growing evidence of current and ongoing systemic issues contributing to this increase, there continues to be a lack of administrative engagement to address ED attendance, with avoidance and diversion strategies initiated during the COVID‐19 pandemic no longer prioritised, despite growing need. Clear and well‐documented reports of ED overcrowding and bed boarding is evidence that things need to change. Moreover, if innovative action is not taken, the risk and reality is that long waits, poor outcomes and exposure to unsafe conditions will continue. This is broadly unacceptable to consumers, their carers and the broader ED network. Delayed action in seeking alternative solutions only reinforces the risk and reality that people experiencing mental health concerns have ‘Nowhere Else To Go’.
Silencing of V‐ATPase‐E gene causes midgut apoptosis of Diaphorina citri and affects its acquisition of Huanglongbing pathogen
Authors: Guo Chang‐Fei , Qiu Jun‐Hong , Hu Yu‐Wei , Xu Pei‐Ping , Deng Ying‐Qi , Tian Ling , Wei Yi‐Yun , Sang Wen , Liu Yu‐Tao , Qiu Bao‐Li 
Published: November 2022

AbstractThe Asian citrus psyllid, Diaphorina citri Kuwayama, is among the most important pests of citrus. It is the main vector of the Huanglongbing (HLB) pathogen Candidatus Liberibacter asiaticus (CLas), which causes severe losses in citrus crops. Control of D. citri is therefore of paramount importance to reduce the spread of HLB. In this regard, using RNA interference (RNAi) to silence target genes is a useful strategy to control psyllids. In this study, using RNAi, we examined the biological functions of the V‐ATPase subunit E (V‐ATP‐E) gene of D. citri, including its effect on acquisition of CLas. The amino acid sequence of V‐ATP‐E from D. citri had high homology with proteins from other insects. V‐ATP‐E was expressed at all D. citri life stages analyzed, and the expression level in mature adults was higher than that of teneral adults. Silencing of V‐ATP‐E resulted in a significant increase in mortality, reduced body weight, and induced cell apoptosis of the D. citri midgut. The reduced expression of V‐ATP‐E was indicated to inhibit CLas passing through the midgut and into the hemolymph, leading to a majority of CLas being confined to the midgut. In addition, double‐stranded RNA of D. citri V‐ATP‐E was safe to non‐target parasitic wasps. These results suggest that V‐ATP‐E is an effective RNAi target that can be used in D. citri control to block CLas infection.
Assessment of Triozoida limbata (Hemiptera: Triozidae) attacks: morphological and biochemical changes on Psidium guajava plants
Authors: Picanço Mayara M. , Silva Ricardo S. , Azevedo Aristea A. , Lima Lucas L. , Ramos Humberto J. O. , Souza Og F. F. , Carmo Flávia M. S. , Picanço Marcelo C. 
Published: November 2022

AbstractThe relationship between herbivorous insects and plants is an example of an ‘evolutionary arms race’. Understanding the relationship between insects and their host plants makes it possible to determine critical points in the bioecology of these herbivores. In this relationship, insects and plants use strategies to overcome, avoid and mitigate the actions of the other. Insect‐induced galls are one of the great examples of this ‘arms race’. Psyllids (Hemiptera: Psylloidea) are among the most important gall‐inducing insects. The psyllid Triozoida limbata (Triozidae) is an important pest of guava (Psidium guajava) in the Neotropics. Thus, this work aimed to determine the morphological, anatomical, and biochemical changes in guava leaves caused by T. limbata to study the ‘arms race’ between these two organisms. Therefore, the process of gall formation on guava leaves during the psyllid life cycle was described. A comparative study of the anatomy and levels of phytohormones in leaves attacked and not attacked by the psyllid was carried out. It was found that the psyllid attack triggered the plant's defence by increasing the jasmonic acid content in the leaves. The psyllid attack caused anatomical changes in the leaves (such as cell non‐differentiation), allowing the insect to survive feeding on the plant. In addition, the psyllid‐induced galls provided shelter for the psyllid.
Morphometric analysis of the spinal cord of the Sus scrofa (large white and landrace crossbreed)
Authors: Femi‐Akinlosotu Omowumi , Olopade Funmilayo Eniola , Mustapha Oluwaseun , Adekanmbi Adejoke , Olopade James O. 
Published: November 2022

AbstractThe incidence of spinal cord (SC) injury in developed and undeveloped countries is alarming. The pig (Sus scrofa) has been recommended as a suitable research model for translational studies because of its morphophysiological similarities of organ systems with humans. There is a dearth of information on the SC anatomy of the large white and landrace crossbreed (LW‐LC) pigs. We therefore aim to describe the gross morphology and morphometry of its SC. Twelve juvenile LW‐LC pigs (six males and six females) were used. The skin and epaxial muscles were dissected to expose the vertebral column. The SC was carefully harvested by laminectomy, and 13 gross SC morphometric parameters were evaluated. Thirty‐three spinal nerves were seen emanating from either side of the SC by means of dorsal and ventral spinal roots. The overall average of SC length and weight was 36.23 ± 1.01 cm and 16.60 ± 0.58 g, respectively. However, the mean SC length and weight were higher in females compared with males, with SC weight being statistically significant. A positive relationship between SC length and weight was significant for males (p = 0.0435) but not for females (p = 0.42). Likewise, the strength of the relationship between SC length and weight was significant in males (r = 0.82) but not significant in females (r = 0.41). Baseline data for the morphometric features of the spinal cord in the LW‐LC pigs were generated, which will contribute to the knowledge of this species anatomy and useful information on regional anaesthesia that should further strengthen the drive in adopting the pig as a suitable research model for biomedical research.
A new approach to postvasectomy semen analyses eliminates the need to evaluate a fresh specimen
Authors: Kiessling Ryan J. , Hauser Alexander , Eyre Robert C. , Kiessling Ann A. 
Published: November 2022

AbstractBackgroundAccording to current guidelines, confirmation that vasectomy results in sterility depends on microscopic examination of postvasectomy semen for the presence of spermatozoa. Guidelines established in 2012 require examination of a fresh specimen within 2 h of collection, which necessitates the patient making an appointment with either the surgeon's office or a licensed clinical laboratory. Twenty‐five to 42% of patients fail to comply with postvasectomy semen analysis (PVSA).ObjectivesTo determine if an at‐home semen collection kit can substitute for the evaluation of a fresh specimen and improve patient compliance with postvasectomy spermatozoa assessment.Materials and methodsThe kit contains a patented aldehyde‐fixative that maintains spermatozoa and semen cells in suspension for quantitation. Patients order a PVSA kit to be delivered to their home and can collect a semen specimen and return it to the laboratory through regular US mail.ResultsFrom January 2011 through December 2018, 6096 men undergoing vasectomy by 184 urologists in 33 states in the US ordered PVSA kits, of which 5408 (89%) returned at least one for analysis. Of those, 398 men (7.4%) returned the first kit with greater than 10,000 spermatozoa/ml within a year of vasectomy, of which only 4.4% contained greater than 100,000 spermatozoa/ml 12 weeks postsurgery. This suggests that fewer than 5% of postvasectomy patients might need follow‐up fresh semen analyses, greatly easing the logistical burden of PVSA. Ninety percent of surgeons returning a patient satisfaction questionnaire said their patients “never” complained about using PVSA kits.Discussion and conclusionThese data support the adoption of a new standard for PVSA that does not involve an initial evaluation of a fresh semen specimen.
Incidence of second primary cancers among survivors of childhood cancer: A population‐based study, Osaka, Japan, 1975–2015
Authors: Odani Satomi , Nakata Kayo , Inoue Masami , Kato Mizuki , Saito Mari Kajiwara , Morishima Toshitaka , Hashii Yoshiko , Hara Junich , Kawa Keisei , Miyashiro Isao 
Published: November 2022

AbstractSecond primary cancer (SPC) is one of the most life‐threatening late effects of childhood cancers. We investigated the incidence and survival outcomes of SPC in childhood cancer patients in Japan. Data were obtained from the population‐based Osaka Cancer Registry. Individuals diagnosed with cancer at age 0–14 years during 1975–2014 and survived 2 months or longer were followed through December 2015. The risk of developing SPC was assessed with standardized incidence ratio (SIR), excess absolute risk (EAR, per 100,000 person‐years), and cumulative incidence. Multivariable Poisson regression analysis was carried out to assess relative risks of SPC by treatment method. Survival analysis was undertaken using the Kaplan–Meier method. Of 7229 childhood cancer survivors, 101 (1.4%) developed SPC after a median of 11.6 years. Overall SIR was 5.0, which corresponded with 84.3 EAR. The cumulative incidence was 0.9%, 2.1%, and 3.4% at 10, 20, and 30 years, respectively. Among all SPCs, the type that contributed most to the overall burden was cancers in the central nervous system (EAR = 28.0) followed by digestive system (EAR = 15.1), thyroid (EAR = 8.3), and bones and joints (EAR = 7.8); median latency ranged from 2.0 years (lymphomas) to 26.6 years (skin cancers). Patients treated with radiotherapy alone were at a 2.58‐fold increased risk of developing SPC compared to those who received neither chemotherapy nor radiotherapy. Among patients who developed SPCs, 5‐year and 10‐year survival probabilities after SPC diagnosis were 61.7% and 52.0%, respectively. Risk‐based long‐term follow‐up planning is essential to inform survivorship care and help reduce the burden of SPCs in childhood cancer survivors.