bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Understanding of Ultra-Deepwater Thin Beds Interpretation and Compartmentalization in Light of New Seismic Reprocessed Data and Well Results
Authors: Mostapa Muhammad Ferdaos , Patrick Alex Tarang , Nguyen Huu Nghi , Tata Arie Purba 
Published: March 2022

Abstract
Deepwater fields are well known for their complex turbidite heterogeneity. J field, which has a water depth of 1600-1800 meters, is a distal deepwater turbidite fan located within a high compressional area, resulted in highly faulted structures. All wells drilled in the J field penetrated thin-bedded sand-shale reservoirs (average 30-80 cm) which are below current available tools’ resolution. This has directly impacted the accuracy of reservoirs properties interpretation and characterization.
Additionally, based on the acquired pressure data from past appraisal campaigns, the field is proven to be laterally and vertically compartmentalized. However, reservoir connectivity and producibility away from those appraisal wells remains uncertain and challenging to be identified, due to the legacy 3D seismic image quality, limitation in data resolutions, and limited regional data.
This paper will briefly address the challenges of deepwater distal turbidites understanding while proposing a holistic workflow with the integration of 3D seismic and well data to enhance thin-bed interpretation and complex compartmentalization prediction.
Novel Microemulsion Breaker System Remove Drill-in-Fluids Filter Cake and Remediate Near Wellbore Damage to Enhance Productivity of Horizontal Wells of Offshore Sabah, Malaysia
Authors: Jaffar Nurul Amyra , Luan Nan , Arisandi Edo 
Published: March 2022

Abstract
In a case study of four wells located in offshore Sabah Malaysia, a field application using microemulsion technology to develop a customized in-situ breaker solution enhanced production rate by removing oil-based mud (OBM) and synthetic based mud (SBM) filter cake and remediating near-wellbore damage. All wells were completed as open–hole horizontal wells. Key challenges of the field are the multiple sand layers interbedded with intra-reservoir shale intervals necessitating a complex well trajectory and an operational preference for drilling with SBM drill-in fluid (SBM DIF). Lower than expected production rates were associated a water-impermeable SBM DIF filter cake and solids residue resulting from a conventional breaker system being unable to fully remove emulsion damage and effectively disrupt the filtercake.
A series of laboratory tests for return permeability using formation cores from the offset wells and ceramic discs were completed as part of a feasibility study prior to field trials of the new microemulsion breaker system - a customized formulation consisting of a proprietary surfactant blend, organic acid, corrosion inhibitor and brine designed to remove the damage caused by the SBM DIF and restore open-hole flow conditions. The new breaker system has ultra-low interfacial tension which, when pumped into the open-hole section and allowed to soak for a sufficient period of time, diffuses into the rock matrix and forms an in-situ microemulsion completely and uniformly cleaning the near wellbore environment of SBM DIF residue, dispersing solids and leaving all surfaces water-wet.
Laboratory results described in this paper show that the customized microemulsion breaker has the capability to remove SBM DIF filter cake, remediate emulsion damage caused by SBM-DIF, and restores the rock matrix back to its original permeability and predrilled state. All four wells in this field application have exceeded their expected production rate. The customized microemulsion breaker is the major contributing factor.
IL-22 Plays a Dual Role in the Amniotic Cavity: Tissue Injury and Host Defense against Microbes in Preterm Labor
Authors: Gershater Meyer , Romero Roberto , Arenas-Hernandez Marcia , Galaz Jose , Motomura Kenichiro , Tao Li , Xu Yi , Miller Derek , Pique-Regi Roger , Martinez Gregorio , Liu Yesong , Jung Eunjung , Para Robert , Gomez-Lopez Nardhy 
Published: March 2022

Abstract
IL-22 is a multifaceted cytokine with both pro- and anti-inflammatory functions that is implicated in multiple pathologies. However, the role of IL-22 in maternal-fetal immunity in late gestation is poorly understood. In this study, we first showed that IL-22+ T cells coexpressing retinoic acid–related orphan receptor γt (ROR-γt) are enriched at the human maternal-fetal interface of women with preterm labor and birth, which was confirmed by in silico analysis of single-cell RNA sequencing data. T cell activation leading to preterm birth in mice was preceded by a surge in IL-22 in the maternal circulation and amniotic cavity; however, systemic administration of IL-22 in mice did not induce adverse perinatal outcomes. Next, using an ex vivo human system, we showed that IL-22 can cross from the choriodecidua to the intra-amniotic space, where its receptors (Il22ra1, Il10rb, and Il22ra2) are highly expressed by murine gestational and fetal tissues in late pregnancy. Importantly, amniotic fluid concentrations of IL-22 were elevated in women with sterile or microbial intra-amniotic inflammation, suggesting a dual role for this cytokine. The intra-amniotic administration of IL-22 alone shortened gestation and caused neonatal death in mice, with the latter outcome involving lung maturation and inflammation. IL-22 plays a role in host response by participating in the intra-amniotic inflammatory milieu preceding Ureaplasma parvum–induced preterm birth in mice, which was rescued by the deficiency of IL-22. Collectively, these data show that IL-22 alone is capable of causing fetal injury leading to neonatal death and can participate in host defense against microbial invasion of the amniotic cavity leading to preterm labor and birth.
NeoScore Integrates Characteristics of the Neoantigen:MHC Class I Interaction and Expression to Accurately Prioritize Immunogenic Neoantigens
Authors: Borden Elizabeth S , Ghafoor Suhail , Buetow Kenneth H , LaFleur Bonnie J , Wilson Melissa A , Hastings K Taraszka 
Published: March 2022

Abstract
Accurate prioritization of immunogenic neoantigens is key to developing personalized cancer vaccines and distinguishing those patients likely to respond to immune checkpoint inhibition. However, there is no consensus regarding which characteristics best predict neoantigen immunogenicity, and no model to date has both high sensitivity and specificity and a significant association with survival in response to immunotherapy. We address these challenges in the prioritization of immunogenic neoantigens by (1) identifying which neoantigen characteristics best predict immunogenicity; (2) integrating these characteristics into an immunogenicity score, the NeoScore; and (3) demonstrating a significant association of the NeoScore with survival in response to immune checkpoint inhibition. One thousand random and evenly split combinations of immunogenic and nonimmunogenic neoantigens from a validated dataset were analyzed using a regularized regression model for characteristic selection. The selected characteristics, the dissociation constant and binding stability of the neoantigen:MHC class I complex and expression of the mutated gene in the tumor, were integrated into the NeoScore. A web application is provided for calculation of the NeoScore. The NeoScore results in improved, or equivalent, performance in four test datasets as measured by sensitivity, specificity, and area under the receiver operator characteristics curve compared with previous models. Among cutaneous melanoma patients treated with immune checkpoint inhibition, a high maximum NeoScore was associated with improved survival. Overall, the NeoScore has the potential to improve neoantigen prioritization for the development of personalized vaccines and contribute to the determination of which patients are likely to respond to immunotherapy.
Fasting versus postprandial state
Authors: Futela Dheeman , Maheswari K. , Khanna Tejasvini 
Published: March 2022

Context:
Thyroid dysfunctions are common health problems worldwide. Thyroid function tests (TFTs) are the mainstay of diagnosis. A common question by labs and clinicians is whether food intake makes a clinically significant difference for TFTs.

Aims:
We aimed to assess the effect of fasting and postprandial state on thyroid-stimulating hormone (TSH), free T3, and free T4.

Settings and Design:
A cross-sectional study was conducted. Sixty patients were prospectively selected.

Subjects and Methods:
Patients were divided into two groups: Group A (known case of thyroid disorder and on medication) and Group B (no prior history of thyroid dysfunction). Two blood samples were collected from each patient, before and after breakfast, with a gap of 2 h. Serum samples were analyzed for TSH, free T3, and free T4.

Results:
Mean (± standard deviation) TSH values (mIU/L) in fasting state were 2.38 ± 1.88 and in postprandial state were 2.08 ± 1.65. A statistically significant postprandial decline was observed in TSH values (mean difference: -0.30 mIU/L) and free T3 (mean difference: –0.21 pmol/L), in both groups.

Conclusions:
TFT results were altered in a statistically significant manner after food intake. Multiple studies have reported a similar postprandial decline in serum TSH. This may impact the diagnosis and management of thyroid patients, especially where minor changes in TSH levels are clinically relevant.
REVISITING TAGORE: AN ICONOCLAST WITH A VOICE AGAINST SOCIAL BIGOTRIES THROUGH METAPHYSICAL CONCEPTS
Authors: Sattar Shaila Binte 
Published: March 2022

Tagore is a name that does not welcome any introduction. His pieces have been explored and interpreted with versatility, diversity, and, to some extent, brutality. This paper analyses select Tagorean strokes in Gitanjali (1910) to find the voices against social dogmatism as felt by the poet. Relating to contemporary society, it can be viewed that Tagore was ahead of time in foreseeing the significance of a bigotry-free system where life and humans are rejoiced upon subduing class struggle, presumption, and discrimination. This study addresses these problematic facets of human society with close attention towards Tagorean philosophy and evaluation of institutionalised beliefs. It also assesses his use of metaphysics in establishing the power of communal harmony and coherence where every individual is equal.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0938/a.php" alt="Hit counter" /></p>
Pengaruh Disiplin, Motivasi Kerja dan Gaya Kepemimpinan terhadap Kinerja Pegawai di Kantor Badan Perencanaan, Penelitian dan Pengembangan Daerah Kabupaten Sigi
Authors: A. Abbas Rahmi Talib , Mahardiana Lina , Muhammad Zakir 
Published: March 2022

This research revealed the Influence of Dicipline (X1), Work Motivation (X2) and Leadership Style (X3), toward Employee Performance (Y) in Research and Development Planning Agency of Sigi Regency. The purpose of this research is to analyse the influence of Work Dicipline, Motivation and Leadership Style, toward Employee Performance in Research and Development Planning Agency of Sigi Regency. This reseach is classified as a verificative researh and use a survey research design. Source of data is divided into primary data which are collected through questionnaires and secondary data which is collected from a documentary study which has relation with this research. The analysis method used in this research is linear and multiple regression analysis which is also supported by a statistical program of SPSS 20.0 version. Result of this research shows that work discipline, work motivation and leadership style has simultaneity significant influence on the employee performance with R square value 0,361 or 31,6%. While partially this research result is as follows, the discipline has a positive but not significant influence to the employee performance (24,1%), work motivation has a positive and significant influence to the employee performance (63,9%) and leadership style has a positive and significant influence to the employee performance (32,4%). Leader of Research and Development Planning Agency of Sigi Regency must deliver the task to its employee through discipline and responsibility based on regulation so that the employee could give their best service and performance in return.
Pengaruh Technology Readiness Index Terhadap Keinginan Untuk Menggunakan Internet Banking Pada PT Bank Mandiri KCP Pondok Chandra Surabaya
Authors: Auliandri Tuwanku Aria , Arimbi Rahesti Dyah 
Published: March 2022

This study aims to measure the degree of readiness of the individual to intention to use internet banking on PT Bank Mandiri Surabaya. Approach with Technology Readiness index, have four variables that can measure the level readiness that is Optimism, innovativeness, discomfort, and insecurity. This research is quantitative research with 100 respondents who conduct financial transaction. The data were analyzed using structural equation model (SEM) variants based, that is Partial Least Square (PLS) with SmartPLS 2.0 program. The result of analysis found that two construct of technology readiness positive effect to intention to use internet banking that is Optimism dan Innovativeness, but the result of Innovativeness found had no impact to intention to use internet banking. While construct Discomfort dan Insecurity had negative effect to intention to use internet banking, but surprisingly construct insecurity found had impact to intention to use internet banking.
Soft Skill Dan Kinerja Karyawan: Studi Kasus Pada Kantor BPJS Kesehatan Gorontalo
Authors: Tangahu Mohamad Rifan , Yantu Irwan , Podungge Robiyati 
Published: March 2022

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh soft skill terhadap kinerja karyawan pada Kantor BPJS Kesehatan Cabang Gorontalo. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif. Pengumpulan data pada penelitian ini melalui kuesioner yang disebarkan kepada 32 responden yang menjadi sampel. Data dianalisis dengan menggunakan regresi sederhana. Hasil penelitian menunjukan bahwa secara statistik memenuhi kriteria hipotesisnya dimana H0 ditolak dan Ha diterima atau soft skill memiliki pengaruh positif terhadap kinerja karyawan. Untuk pengaruh soft skill (X) adalah sebesar 0,000 < 0,05 dan thitung 4,862 > ttabel 1,695. Yang apabila nilai keduanya dibandingkan maka thitung lebih besar dari ttabel, yang menjelaskan soft skill memiliki pengaruh terhadap kinerja karyawan pada Kantor BPJS Kesehatan Cabang Gorontalo. Berdasarkan hasil analisis dapat disimpulkan bahwa jika semakin baik soft skill maka akan semakin meningkat kinerja karyawan. Berdasarkan perhitungan koefisien determinasi diperoleh nilai R square 0,441 atau 44,1% dapat menentukan besaran pengaruh yang diberikan oleh soft skill terhadap kinerja karyawan. Dengan demikian, hipotesis penelitian teruji kebenarannya dan dapat diterima.
Аутсорсинг охраны труда и его функциональное взаимодействие с другими процессами менеджмента в организации
Authors: Атабаева Мамура , Атабаев Кахрамон , Петросова Лариса 
Published: March 2022

В данной статье, основой, является то,что на сегодняшний день развитие системы управления охраной труда (СУОТ) в организациях практически остановилось. И во многих областях деятельности, особенно в частных предприятиях, существует большая брешь в понимании цели и задач охраны труда. По мнению авторов, такое состояние вызвано острой некомпетентностью работодателей, работников. А также, частичной незавершенностью действующей СУОТ. Вследствие, вышесказанного возникают риски для жизни и здоровья работников, и потеря их трудоспособности. Из-за чего, мировое ВВП теряет от 4% до 5% ВВП в год от потери трудоспособности работников. В тоже время, при длительной потери трудоспособности потери в ВВП могут достигать 10%.
В ходе изучения вопроса, авторы пришли к выводу, что популяризация практики применения внешнего управления охраны труда (аутсорсинга) является важным шагом. Особенно, для решения вопроса безопасности трудящихся в частных предприятиях. Но, в Узбекистане предлагаемый рынок услуг в области аутсорсинга охраны труда очень скуден, всего 5 организаций по всей Республики может предложить, данный вид услуг. Одной из причин, этому является достаточно спорное и неоднозначное взаимодействие аутсорсеров и внутренних служб в организации. В следствии того, что СУОТ охватывает практически все процессы в организации хозяйственной деятельности предприятия. В ходе анализа, в основной части статьи, предлагаются возможные предложения, по улучшению взаимодействия внутренних процессов менеджмента и внешнего аутсорсинга охраны труда.
Янги Ўзбекистон шароитида сайёр суд мажлисларининг aҳоли орасидаги самарадорлиги
Authors: Саидов Ҳабиб 
Published: March 2022

Мазкур мақолада фуқаролик суд ишларини юритишда ошкоралик тамойили ва жамоатчилик назоратини таъминлашнинг долзарб масалалари ўрин олган. Ўзбекистонда давлат органлари фаолиятининг очиқлиги ва жамоатчилик назоратини таъминлашга доир қонунчиликнинг шаклланиши ва ривожланиши, фуқаролик суд ишларини юритишда ошкоралик тамойилини татбиқ этишнинг айрим масалалари ҳамда фуқаролик суд ишларини юритишда жамоатчилик назоратини таъминлаш воситалари ва уларни такомиллаштириш масалалари ўрин олган.
LEADERSHIP QUALITIES AND THEIR CONSEQUENCIES IN AN ORGANIZATIONAL CONTEXT: LITERATURE REVIEW
Authors: Githui John Ngatia 
Published: March 2022

Purpose: It is argued that leadership qualities are very essential and important for the overall performance of organizations as those leaders who possess certain qualities influence the level of growth for organizations. This is notable in influencing decisions that concerns allocation of resources for the existing departments in organizations. The general assumption is that all leaders do possess the necessary and requisite qualities that would enhance the achievement of the desired goals and objectives of organizations. The foregoing is certainly not always the case as most individuals do have limited knowledge as regards the qualities that are important for individuals in the leadership positions.
Methodology: The study provides the linkage between leadership qualities, followership styles or behaviors, and their impact to the overall performance of organizations.
Findings: The study has established that various positive leadership qualities do positively affect individual and overall organizational performance and productivity. Further, the study established that there is a correlation between the leadership qualities exhibited by the leaders and followership styles and behaviors. Though leadership qualities directly affect both the performance of individuals and the overall organization, the impact is also dependent on the followership styles exhibited by the followers/employee. Followership styles and behaviors mediates the relationship between leadership qualities and organizational performance. The identified constructs from the study were found to have an impact on the performance of organization which would ultimately enhance the competitive advantage of the same. The research established that when positive leadership qualities are combined with followership styles such as the exemplary and pragmatist, they enhance the performance of organization in the achievement of the set goals and objectives. The paper has further highlighted the role of followership in creating that environment for optimal performance of organizations.
Numerical Solution of the Stefan Problem for an Artificial Ice Island
Authors: Конов Д. С. , Муратов М. В. , Бирюков В. А. 
Published: March 2022

В работе изучается двумерный ледовый остров в Арктике. Сформулирована задача Стефана для изменения фазового состояния вещества. Разработан численный метод ее решения. Этот метод модифицирован для учета эффектов внешней среды, которые не учитывает физическая модель. Кратко обсуждены идеи для учета солености воды и льда, скорости ветра, а также течения воды, эти подходы реализованы в программе. Для разработанной модели проведен ряд численных экспериментов на ледовом острове. Для этого ледового острова найдено распределение температур в разных постановках, в том числе с учетом массива донного грунта глубиной 10 метров после намораживания и через 150 дней в экстремальных условиях.
We studied a wo-dimensional ice island in Arctic. A phase transition problem also called the Stefan problem is stated. A numerical method for solving it is developed. This method is modified to consider the environment effects which are not present in the physical model. We also briefly discuss approaches to including ice and water salinity, wind speed, and water currents as they are software-implemented. A series of numerical experiments for the ice island are conducted using the simulation model. The temperature fields inside the ice island after are found also taking into account the presence of a 10 m thick seabed soil after freezing and for various extreme environmental conditions.
Simulation of Liquid Displacement in Porous Media and Interphase Chemical Interactions
Authors: Душин В. Р. , Никитин В. Ф. , Скрылева Е. И. , Макеева М. Н. , Манахова А. Н. 
Published: March 2022

В работе рассматриваются особенности математического моделирования процесса вытеснения нефти из пористого пласта с применением термохимических методов увеличения нефтеотдачи. Особенностью данных методов является то, что в результате экзотермической химической реакции между фильтрующимися флюидами температура нефти повышается, а вязкость падает, в результате чего ускоряется процесс вытеснения. Кислотная обработка заключается в нагнетании раствора кислот в пористый пласт при давлении ниже давления разрыва. Кислота растворяет часть породы и загрязнений, образуя расходящуюся от ствола скважины сеть каналов, в результате чего повышается проницаемость пористой среды. Продукты реакции, ввиду их высокой растворимости, не выпадают в осадок и после проведения кислотной обработки и запуска скважины выносятся вместе с продукцией скважины.
The paper deals with the simulation of oil displacement from a porous reservoir using thermochemical stimulation. An exothermic chemical reaction between the fluids increases the oil temperature and decreases the viscosity. As a result, the displacement is accelerated. Acidizing involves injecting an acid solution into a porous formation at a pressure below the fracture pressure. The acid dissolves part of the rock and contaminants, forming a network of channels diverging from the wellbore. It increases the permeability of the porous medium. The reaction products are highly soluble and do not precipitate. After acid injection and well startup, they are removed with the product.