bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epigenetics in Eye Development and Ocular Disorders: A Brief
Review
Authors: Kuchay Raja Amir Hassan , Hassan Asima , Mir Yaser Rafiq 
Published: October 2022

Abstract:
Epigenetics is a powerful regulator of gene expression. With advanced discoveries
in underlying molecular mechanisms that can alter chromatin response to
internal and external signals, epigenetic alterations have been implicated in various
developmental pathways and human disorders. The extent to which this epigenetic
effect contributes to eye development and progression of ocular disorders is currently
less defined. However, emerging evidence suggests that epigenetic changes are relevant
in the development of eye and ocular disorders like pterygium, age-related macular
degeneration, glaucoma and more. This brief review will discuss the relevance of
epigenetic mechanisms like DNA methylation, histone modifications, polycomb proteins
and noncoding RNAs in the context of eye development and selected ocular disorders.
The Role of Vitamins in DNA Methylation as Dietary Supplements
or Neutraceuticals: A Systematic Review
Authors: Fareed Muhammad Mazhar , Ullah Sana , Qasmi Maryam , Shityakov Sergey 
Published: October 2022

Abstract:
Epigenetic modifications play a vital role in gene regulation associated with
different pathologies. Various nutrients in our diet, such as vitamins can modulate these
epigenetic mechanism. They also can regulatenderlying pathophysiological factors
and processes that directly or indirectly. Most importantly, A, B, C, and D vitamins
have recently been shown to be involved in this type of regulation together with vitamins
E and K. Despite their effect on the DNA methylation process, an in-depth understanding
of vitamin-mediated epigenetic alterations have yet to be investigated.
Moreover, the role of vitamins in DNA methylation as nutraceuticals might be important
to use for targeted therapy of various human diseases. Overall, this review provides a
brief survey of the role of vitamins as epigenetic modulators or nutraceuticals, emphasizing
their potential in epigenetic therapy.
Key Targets and Molecular Mechanisms of Active Volatile Components of
Rabdosia rubescens in Gastric Cancer Cells
Authors: Hu Yanhui , Cui Qingli , Ma Dongyang , Jin Wenwen , Li Yingyue , Zhang Jianhua , Xu Youqi 
Published: October 2022

Objective:
To examine the effect and mechanism of volatile components of Rabdosia
rubescens on gastric cancer.

Methods:
Gas chromatography-mass spectrometry was used to detect and identify the volatile
components of R. rubescens. The network pharmacology method was used to analyze the targets
of volatile components of R. rubescens in gastric cancer and to reveal their molecular mechanisms.
The effects of volatile components of R. rubescens on gastric cancer cells were verified by biological
experiments.

Results:
Thirteen volatile components of R. rubescens were selected as pharmacologically active
components. The 13 active components had 83 targets in gastric cancer, and a Traditional Chinese
Medicine-component-targets gastric cancer network was successfully constructed. Five core targets
were obtained: TNF, IL1B, MMP9, PTGS2 and CECL8. The volatile components inhibited
the proliferation of gastric cancer cells in a concentration-dependent manner and promoted the
apoptosis of gastric cancer cells. The volatile components reduced the levels of TNF, IL1B, MPP9,
and PTGS2 in a concentration-dependent manner.

Conclusion:
Our study demonstrates the effects of volatile components in R. rubescens on gastric
cancer and provides preliminary findings on their mechanisms of action.
Trends and Application of Analytical Methods for the Identification and
Quantification of Dexamethasone in Drug Delivery System
Authors: da Silva Leite Joandra Maísa , Barros Araújo Camila Beatriz , Alves Larissa Pereira , Bezerra Pereira Milena Raissa , Guedes Gabryella Garcia , de Carvalho Moreira Lívia Maria Coelho , Rocha Beatriz Patrício , Borges Joyce Cordeiro , de Azevedo Eduardo Pereira , Alencar Fernandes Felipe Hugo , Oshiro Junior João Augusto , de Lima Damasceno Bolívar Ponciano Goulart 
Published: October 2022

Background:
Dexamethasone (DEXA) is a potent synthetic corticosteroid derived
from the cyclopentanoperhydrophenanthrene nucleus known for its anti-inflammatory and immunosuppressive
activities. Due to its therapeutic effects, several analytical methods have been
used for its quantitative determination and physicochemical characterization, as well as for the
evaluation of pharmacological and toxicological properties.

Objective:
This review aimed to describe the principles and methods commonly used to identify
and quantify DEXA in drug delivery systems and biological samples. The methods herein discussed
are high-performance liquid chromatography, nuclear magnetic resonance, x-ray diffraction,
Fourier-transform infrared spectroscopy, differential scanning calorimetry, ultravioletvisible
spectrophotometry and thin layer chromatography.

Conclusion:
This review provided a wide variety of analytical methods that can be used for the
quantification and identification of drugs, providing scientists with great support during the development
of scientific research, as well as ensuring the quality of the manufacturing processes
as well as the resulting products. Therefore, the use of such analytical methods has become critical
throughout the process of developing pharmaceutical formulations containing DEXA.
Effect of Prebiotic Supplementation on Probiotic Viability and Physicochemical
Characteristics of Fermented Coconut Water with Bifidobacterium
longum
Authors: Jahajeeah Meghna , Choo Wee Sim 
Published: October 2022

Background:
Probiotics and prebiotics are functional ingredients that provide health benefits to consumers but they are mainly incorporated in dairy products. Designing a non-dairy product in which probiotics and prebiotics would be incorporated would allow more consumers to benefit from their advantages.

Objective:
This study investigated the effect of supplementation of two different prebiotics, fructooligosaccharide (FOS) and inulin, on the viability of Bifidobacterium longum ATCC BAA-999 in coconut water.

Methods:
Two concentrations of prebiotics used were 1% and 2%. The physicochemical characteristics of fermented coconut water with B. longum for 9 h at 37oC and during refrigerated storage at 4oC for 2 weeks were analyzed. The viability of B. longum in fermented coconut water was maintained above the recommended therapeutic level (7 log CFU/mL) with or without supplementation with prebiotics.

Results:
Most distinct changes in colour (∆E > 3) occurred in fermented coconut water compared to unfermented coconut water. An increase in the total soluble solids was also observed in fermented coconut water with the increase in the concentration of prebiotics. There were no significant changes in the clarity, pH, and concentrations of shikimic and malic acids in the fermented coconut water with or without supplementation with prebiotics over the 2 weeks of storage. Acetic acid production was observed in the fermented coconut water with the highest acetic acid production in the fermented coconut water supplemented with 1% FOS after 2 weeks of storage.

Conclusion:
This study demonstrated the potential use of coconut water as a medium to produce a probiotic drink.
Pengaruh Islam dan Eropa dalam Budaya Kuliner di Keraton Yogyakarta dan Surakarta Abad 19 dan 20 Masehi
Authors: Thohir Ajid , Azhara Bambang Muhamad Fasya 
Published: October 2022

Islam and Europe are an integral part of the life of Keraton Yogyakarta and Surakarta, especially in the culinary culture of the keraton. This study aims to identify of the influence of Islam and Europe on culinary cultures at keraton yogyakarta and surkarta in the 19-20 centuries c.e., as well as the forms resulting from that influence. T he research methods used historical research methods, which refer to various sources categorized into primary and secondary sources. The p rimary sources include photo archives, newspapers, to invitation cards. As for secondary sources it is made up of books and articles. The results of this research identify what is h alal or lawful and haram or prohibited in the culinary culture. The keraton thus attempted to modify a variety of European dishes to be enjoyed without violating islamic teachings. As for the European influence, the rijsttafel, the orchestra, the ingredients used, to the use of a foreign language on the dinner table. Such European influence arose because of the process of interaction between Javanese nobles and europeans, the keraton attempted to imitate European customs.
Sobra monitoramento, falta avaliação: metas e estratégias de um plano estadual de educação
Authors: Ferri Cássia 
Published: October 2022

Os planos nacional, estadual e municipais de educação ocuparam a agenda da área da educação entre 2009 e 2015. Este artigo propõe reflexões sobre o monitoramento e avaliação das metas e estratégias das políticas curriculares e avaliativas, que estão expressos nos dois relatórios de monitoramento, publicados respectivamente em maio de 2018 e agosto de 2020, do Plano Estadual de Educação de Santa Catarina 2015-2024 (PEE-SC) aprovado pela Lei nº 16.794, de 14 de dezembro de 2015. Trata-se de uma pesquisa com dados públicos e oficiais que receberam tratamento orientado pela análise documental, utilizando-se dados quantitativos para fornecer subsídios às análises qualitativas. O descompasso evidente entre o volume de dados gerados pelo monitoramento e as tomadas de decisões advindas das avaliações destes dados possibilita afirmar que os planos estadual e nacional respondem mais as exigências formais do que orientam ações concretas.
Mechanical properties of lightweight expanded clay aggregate (LECA) concrete
Authors: ISSA Atheer S. , Al-ASADI Ali K. 
Published: October 2022

The construction activities are based on structural concrete, which is one of the most commonly used materials. The fundamental aim of using lightweight concrete (LWC) was to reduce the concrete self-weight of the structure parts. As a result, LWC has been used successfully in a variety of installations for several years. In this paper, the mechanical properties of concrete made with lightweight expanded clay aggregate (LECA) as a full replacement for coarse aggregate are studied. The experimental program shows that LECA with a 32 MPa cube compressive strength and an 1,823 kg×m–3 dry density can be used to make structural light-weight aggregate concrete (SLWC). The results show that the reduction in the strength of lightweight aggregate concrete (LWAC) was found to be higher in the concrete with an estimated compressive strength of 32 MPa due to the lower strength of the LWA (expanded clay). According to the test results, the mechanical properties of LWC were greatly improved by adding silica fume (SF). Furthermore, LECA concrete has a splitting tensile strength that is 47% higher than the ASTM C330/C330M-17A minimum requirement. The LECA concrete has a splitting tensile strength to compressive strength ratio of approximately 13%. Additionally, the results demonstrate a 27% difference in the modulus of elasticity between the calculated and tested values.
VALIDITY OF ICT BASED ON INTEGRATED STEM EDUCATION TEACHING MATERIALS TO IMPROVE DATA LITERATURE AND TECHNOLOGY PHYSICS STUDENTS
Authors: Marlina Liza , Asrizal Asrizal 
Published: October 2022

The development of the 21st century demands changes in resources of human of “broad insight, critical thinking, and literacy” to deal with the development of 21st century education. Conditions in the field found that STEM, data literacy and technology had not been implemented, and the average score of students in physics learning had not been implemented. One solution that can be conducted is to develop ICT materials of teaching on work and energy based on STEM Education. This study aims to determine the validity of ICT-based business and energy teaching materials to integrate STEM Education to improve data and technology literacy of high school students.The research conducted includes development research using the development model of Plomp. The development model of Plomp is carried out until the design and prototype stages, namely determining the validity of the product carried out by experts on the product being developed. The results of the study obtained that the assessment of teaching materials was valid on five components based on data analysis using Aiken, V obtained the results for material substance with a value of 0.77, visual communication display with a value of 0.78, learning design with a value of 0.78, software usage with a value of 0.63 and STEM assessment with a value of 0.74. Based on this validity assessment, it can be concluded that ICT-based business and energy teaching materials integrate STEM Education to improve data literacy and valid high school students' technology so that they can be applied to students in learning
Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors
Authors: Sreekantan Abhirami P. , Rajan Pooja P. , Mini Minsa , Kumar Praveen 
Published: October 2022

Abstract
Antimicrobial resistance is becoming a paramount health concern nowadays. The increasing drug resistance in microbes is due to improper medications or over usage of drugs. Bacteria develop many mechanisms to extrude the antibiotics entering the cell. The most prominent are the efflux pumps (EPs). EPs play a significant role in intrinsic and acquired bacterial resistance, mainly in Gram-negative bacteria. EPs may be unique to one substrate or transport several structurally different compounds (including multi-class antibiotics). These pumps are generally associated with multiple drug resistance (MDR). EPs are energized by a proton motive force and can pump a vast range of detergents, drugs, antibiotics and also β-lactams, which are impermeable to the cytoplasmic membrane. There are five leading efflux transporter families in the prokaryotic kingdom: MF (Major Facilitator), MATE (Multidrug And Toxic Efflux), RND (Resistance-Nodulation-Division), SMR (Small Multidrug Resistance) and ABC (ATP Binding Cassette). Apart from the ABC family, which utilizes ATP hydrolysis to drive the export of substrates, all other systems use the proton motive force as an energy source. Some molecules known as Efflux Pump Inhibitors (EPI) can inhibit EPs in Gram-positive and Gram-negative bacteria. EPIs can interfere with the efflux of antimicrobial agents, leading to an increase in the concentration of antibiotics inside the bacterium, thus killing it. Therefore, identifying new EPIs appears to be a promising strategy for countering antimicrobial drug resistance (AMR). This mini-review focuses on the major efflux transporters of the bacteria and the progress in identifying Efflux Pump Inhibitors.
Analysis of the Teaching Quality of Physical Education Class by Using the Method of Gradient Difference
Authors: Li Ji , Aldulaimi Saeed Hameed , Bouldoukian Nathalie 
Published: October 2022

Abstract
In order to have a more in-depth understanding of the current classroom efficiency and quality of physical education classes, the author uses the extreme difference method to analyze the teaching quality of physical education. Train the network with a large number of classified samples, so that the network system with analysis ability can objectively evaluate the teaching quality of teachers; The Labview software tool is used to solve the calculations of the sigmoid function, the gradient descent method (δ learning rule), and the mean square error used in the algorithm, so that the constructed model can realize self-learning and evaluation functions. We designed an education quality evaluation model for the characteristics of education quality evaluation. Based on previous research and practice, we have compiled an evaluation index system that includes 3 primary indicators and 10 secondary indicators. As a result of conducting experiments based on this index system and the quality evaluation model of education, it became clear that this model is effective.
Design of Tennis Mobile Teaching Assistant System Based on Ordinary Differential Equations
Authors: Zhang Xiaoe , Fu Qiang , Deng Yunlin , Alzyoud Adel 
Published: October 2022

Abstract
Tennis is a sport, which is mainly composed of many parts, such as mobile devices, software and hardware. With the rapid development of today's time, people's living standards are getting higher and higher, the traditional teaching mode can no longer meet the user's needs well, so teachers need to help students improve their overall quality with the help of more advanced modern online teaching methods, therefore, the design of a practical and flexible mobile assistance system is necessary for universities nowadays. This paper mainly introduces the tennis auxiliary system based on ordinary differential equations, which is based on the database, and it has the functions of data collection, processing and display. This software is designed and implemented by using javaSwing technology and solidworks development tools. After that, SSH framework is used to create the application and backend management interface for later maintenance and update, so that the management can understand the students' situation at any time and make corresponding decision analysis to better serve the users and improve the quality and level of tennis teaching.
Construction of comprehensive evaluation index system of water-saving irrigation project integrating penman Montei the quation
Authors: Wang Yijia 
Published: October 2022

Abstract
In order to solve the post evaluation system construction of high-efficiency and water-saving irrigation projects, this paper puts forward the research significance of post evaluation technology of high-efficiency and water-saving irrigation projects, summarizes the research status and development trends of post evaluation of projects at home and abroad, and analyzes the existing post evaluation theories and research methods. Based on the actual situation of high-efficiency water-saving irrigation projects, the post evaluation index system of high-efficiency water-saving irrigation projects is constructed from five aspects: construction process, operation management, economy, impact, goal and sustainability by using the method of combining expert questionnaire survey and statistical theory; Study the advantages, disadvantages and scope of application of the existing post project evaluation index weight determination methods and evaluation methods, put forward five single post evaluation standards: post construction process evaluation, post operation management evaluation, post economic evaluation, post impact evaluation, post objective and sustainability evaluation, determine the evaluation process and form five single post evaluation models. Based on the five individual post evaluation models, the project success evaluation model is constructed to form the "5 + 1" post evaluation model of high-efficiency water-saving irrigation project. Taking a high-efficiency water-saving irrigation project as an example, the application process of post evaluation index system and evaluation model of high-efficiency water-saving irrigation project is given, and the feasibility of applying the index system and evaluation model proposed in this paper to production practice is analyzed.
Animation VR scene mosaic modeling based on generalized Laplacian equation
Authors: Chen Danping 
Published: October 2022

Abstract
In order to improve the technology based on the existing animation scene stitching modeling, the animation scene stitching modeling is further studied combined with Laplacian equation. The algorithm uses wavelet transform to decompose the animation scene, and then obtains the low-frequency coefficients and high-frequency coefficients of the animation scene; For the high-frequency coefficients, the splicing rules based on the comparison and screening of the convolution results of two Laplacian template operators are adopted; For the low-frequency coefficients, the splicing rule based on Laplace sharpness evaluation function and 8-neighborhood local variance is adopted; Finally, the inverse wavelet transform is used to obtain the diffuse scene mosaic modeling. The experimental results are analyzed combined with subjective and various objective evaluation methods. The results show that the improved algorithm has better splicing effect than the traditional splicing modeling. Animation scene splicing modeling has the advantages of rich edge information and high scene definition.
A multi-factor Regression Equation-based Test of Fitness Maximal Aerobic Capacity in Athletes
Authors: Li Xiaoling 
Published: October 2022

Abstract
Sports performance is one of the important indicators to evaluate athletes, which reflects the level of physical exercise. In recent years, our national physical quality has been declining and the physical health of young people is unsatisfactory. In order to improve the quality of national health, promote the harmonious development of society and cultivate students' awareness of lifelong fitness, it is necessary and far-reaching to study the most important factors affecting human physical fitness. Sports performance is an important indicator to evaluate athletes, and sports performance is closely related to the level of physical fitness, so the most basic and valuable thing for sportsmen and women is to ensure their body fat and physical fitness. In recent years, with the rapid economic development, social progress and improvement of people's quality of life in China, fitness in such a fiercely competitive environment has become more and more important. Therefore, in order to better promote the national physical health problem to be solved as soon as possible we must do a good job of national fitness program, which can provide more talent support and intellectual support for the national sports career and improve the national physical fitness. In this paper, through the statistics and analysis of athletes' physical health test data, we can provide more talent support for sports programs.
University Library Lending System Model Based on Fractional Differential Equations
Authors: Liu Quanfeng , Hatamleh Ibrahim 
Published: October 2022

Abstract
How to find books suitable for them from the massive book information is a problem that needs to be considered at present for university library users. This paper proposes a personalized recommendation system for digital libraries utilizing fractional differential equations. At the same time, we use the idea of a collaborative filtering algorithm to recommend books for new users. Finally, we use the accurate data of the library to design a personalized book recommendation system for university libraries. The research shows that the university library lending system based on fractional differential equations has improved user experience.