bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metal–Organic Framework Integrating Ionic Framework and Bimetallic Coupling Effect for Highly Efficient Oxygen Evolution Reaction
Authors: Li Shulin , Wang Tienan , Tang Dai , Yang Yuting , Tian Yuyang , Cui Fengchao , Sun Jifeng , Jing Xiaofei , Sholl David S. , Zhu Guangshan 
Published: September 2022

AbstractMetal–organic frameworks (MOFs) are recognized as promising electrocatalysts for the oxygen evolution reaction (OER) because of their permanent porosity and rich architectural diversity; however, ionic MOFs enabling fast ions exchange during OER are rarely explored. Here, an ionic MOF (Ni‐btz) constructed with an azolate ligand is selected, and continuous 3D bimetallic MOF (NiFe‐btz) films deriving from high‐degree intergrowth of microsized MOFs particles are fabricated. The as‐prepared NiFe‐btz/NF‐OH electrode exhibits excellent OER performance with a low overpotential of 239 mV at 10 mA cm−2 under alkaline condition. The OER charge transfer process and bimetallic coupling effect in ionic NiFe‐btz are probed by density functional theory calculations and confirmed via X‐ray photoelectron spectroscopy and in situ Raman measurements. The partial density of states of NiFe‐btz indicates that the main contribution for electron density around the Fermi level is from Cl ions clarifying the profitable impact of ionic MOF framework. This work systematically demonstrates the relationship of electronic structure and OER activity in ionic, bimetallic MOFs and expands the scope of 3D MOF films for efficient OER.
High‐Efficiency Perovskite–Organic Blend Light‐Emitting Diodes Featuring Self‐Assembled Monolayers as Hole‐Injecting Interlayers
Authors: Gedda Murali , Gkeka Despoina , Nugraha Mohamad Insan , Scaccabarozzi Alberto D. , Yengel Emre , Khan Jafar I. , Hamilton Iain , Lin Yuanbao , Deconinck Marielle , Vaynzof Yana , Laquai Frédéric , Bradley Donal D. C. , Anthopoulos Thomas D. 
Published: September 2022

AbstractThe high photoluminescence efficiency, color purity, extended gamut, and solution processability make low‐dimensional hybrid perovskites attractive for light‐emitting diode (PeLED) applications. However, controlling the microstructure of these materials to improve the device performance remains challenging. Here, the development of highly efficient green PeLEDs based on blends of the quasi‐2D (q2D) perovskite, PEA2Cs4Pb5Br16, and the wide bandgap organic semiconductor 2,7 dioctyl[1] benzothieno[3,2‐b]benzothiophene (C8‐BTBT) is reported. The presence of C8‐BTBT enables the formation of single‐crystal‐like q2D PEA2Cs4Pb5Br16 domains that are uniform and highly luminescent. Combining the PEA2Cs4Pb5Br16:C8‐BTBT with self‐assembled monolayers (SAMs) as hole‐injecting layers (HILs), yields green PeLEDs with greatly enhanced performance characteristics, including external quantum efficiency up to 18.6%, current efficiency up to 46.3 cd A−1, the luminance of 45 276 cd m−2, and improved operational stability compared to neat PeLEDs. The enhanced performance originates from multiple synergistic effects, including enhanced hole‐injection enabled by the SAM HILs, the single crystal‐like quality of the perovskite phase, and the reduced concentration of electronic defects. This work highlights perovskite:organic blends as promising systems for use in LEDs, while the use of SAM HILs creates new opportunities toward simpler and more stable PeLEDs.
Recent Progress on Heterojunction Engineering in Perovskite Solar Cells
Authors: Wang Tianyue , Deng Wenqiu , Cao Jiupeng , Yan Feng 
Published: September 2022

AbstractMetal halide perovskite solar cells (PSCs) have become one of the most promising next‐generation photovoltaic technologies due to their low‐cost fabrication, solution processability, and superior optoelectronic properties. Although state‐of‐art PSCs demonstrate a power conversion efficiency record comparable to that of silicon solar cells, there are still many challenges toward commercialization. PSCs are devices based on various semiconductor heterojunctions that all play important roles in device performance. The device operation relies on a combination of multiple heterojunctions to offer a delicate control of photocarrier generation, separation, and transport to respective electrodes. Hence, advanced heterojunction design in PSCs is crucial for the further improvement of device performance. Notably, the conversion efficiency records for PSCs are mainly ascribed to optimized heterojunction engineering. Considering the significance of this topic, a comprehensive review of the recently developed heterojunction designs is presented. Following a brief introduction to PSC architectures, operation, and fundamental heterojunction design theories, the recent progress on perovskite/electron transport layer, perovskite/hole transport layer, and perovskite/perovskite heterojunction engineering is elaborated. Finally, conclusions and perspectives on this research field are addressed.
Rediscovering N‐Methyltetranitropyrrole – A Versatile High Energy MaterialviaFacile Two‐step Eco‐friendly Synthetic Approach
Authors: Thaltiri Vikranth , Shanmugapriya V. , Yadagiri Thigulla , Panda Pradeepta K. 
Published: September 2022

AbstractA highly efficient 2‐step method, where three nitro groups could be directly introduced upon pyrrole moiety in a single step, was developed as an environmentally benign process for the synthesis of N‐methyltetranitropyrrole (1) employing metal nitrate/conc. sulphuric acid as the nitrating reagent. This method resulted1in high purity having higher thermal stability (273 °C) along with reduced sensitivity (impact sensitivity >40 J; fricition sensitivity >360 N), which makes it a versatile high energy material. An over‐oxidized new product 1‐methyl‐3,3,4,4‐tetranitropyrrolidine‐2,5‐dione (4) was also isolated during optimization, whose energetic properties are similar to those of RDX.
Asymmetric Synthesis of Spiro[Azetidine‐3,3′‐Indoline]‐2,2′‐Diones via Copper(I)‐Catalyzed Kinugasa/C−C Coupling Cascade Reaction
Authors: Zhong Xianqiang , Huang Meirong , Xiong Huilan , Liang Yuzhen , Zhou Wei , Cai Qian 
Published: September 2022

AbstractSpiro[azetidine‐indolines] are important scaffolds in diverse bioactive compounds. Current efforts to synthesize spiro[azetidine‐indolines] are limited to chiral spiro[azetidine‐2,3′‐indolines]. Asymmetric synthesis of structurally similar chiral spiro[azetidine‐3,3′‐indolines] remains unexplored. In this work, the first copper(I)‐catalyzed asymmetric Kinugasa/aryl C−C coupling cascade reaction is described. This provides a straightforward access to densely functionalized chiral spiro[azetidine‐3,3′‐indoline]‐2,2′‐diones in good yields and with high enantioselectivity.
Moisture‐Accelerated Precursor Crystallisation in Ambient Air for High‐Performance Perovskite Solar Cells toward Mass Production
Authors: Fan Weili , Deng Kaimo , Shen Ying , Bai Yang , Li Liang 
Published: September 2022

AbstractPhase‐pure crystallised perovskite is considered an excellent precursor for fabricating high‐stability perovskite films with minimal defects. However, currently available protocols for synthesising crystallised perovskites must be conducted in an inert atmosphere or in the presence of an organic solvent as the reaction medium, which hinders mass production. Here, we report the fast synthesis of α‐phase‐crystallised perovskite powder assisted by moisture in ambient air. Moisture can promote the reaction between PbI2 and organic salts and facilitate complete phase transition, as demonstrated in a joint experimental and theoretical study. Perovskite solar cells with a power conversion efficiency of 24.07 % were achieved using phase‐pure crystallised perovskite powder as the precursor. This ambient‐air‐compatible method opens new vistas to reproducible high‐quality precursors for large‐scale photovoltaic applications.
Regioisomer‐Free Difluoro‐Monochloro Terminal‐based Hexa‐Halogenated Acceptor with Optimized Crystal Packing for Efficient Binary Organic Solar Cells
Authors: Yan Lu , Zhang Heng , An Qiaoshi , Jiang Mengyun , Mahmood Asif , Jee Min Hun , Bai Hai‐Rui , Zhi Hong‐Fu , Zhang Shaowen , Woo Han Young , Wang Jin‐Liang 
Published: September 2022

AbstractHerein, we synthesized new hetero‐halogenated end groups with well‐determined fluorinated and chlorinated substitutions (o‐FCl‐IC and FClF‐IC), and synthesized regioisomer‐free small molecular acceptors (SMAs) Y‐Cl, Y‐FCl, and Y‐FClF with distinct hetero‐halogenated terminals, respectively. The single‐crystal structures and theoretical calculations indicate that Y‐FClF exhibits more compact three‐dimensional network packing and more significant π‐π electronic coupling compared to Y‐FCl. From Y‐Cl to Y‐FCl to Y‐FClF, the neat films exhibit a narrower optical band gap and gradually enhanced electron mobility and crystallinity. The PM6 : Y‐FClF blend film exhibits the strongest crystallinity with preferential face‐on molecular packing, desirable fibrous morphology with suitable phase segregation, and the highest and balanced charge mobilities among three blend films. Overall, the PM6 : Y‐FClF organic solar cells (OSCs) deliver a remarkable efficiency of 17.65 %, outperforming the PM6 : Y‐FCl and PM6 : Y‐Cl, which is the best PCE for reported hetero‐halogens‐based SMAs in binary OSCs. Our results demonstrate that difluoro‐monochloro hetero‐terminal is a superior regio‐regular unit for enhancing the intermolecular crystal packing and photovoltaic performance of hetero‐halogenated SMAs.
Fluorination Treatment of Conjugated Protonated Polyanilines for High‐Performance Sodium Dual‐Ion Batteries
Authors: Sun Zhiqin , Zhu Kunjie , Liu Pei , Chen Xuchun , Li Haixia , Jiao Lifang 
Published: September 2022

AbstractThe overall performance of dual‐ion batteries (DIBs) is strongly linked to anions storage properties of cathodes. Whereas high energy/power densities and stabilities for DIBs are limited by cathodes. To overcome these barriers, we have designed a novel fluoridized‐polyaniline‐H+/carbon nanotubes (FPHC) as cathode for high‐efficiency PF6− storage. F− in PF6− is easy to form covalent bond with H on −NH− in FPHC, so that PF6− can stably coordinate with FPHC, showing a symmetrical structure. FPHC cathode shows a highly reversible capacity of 73 mAh g−1 at 2 A g−1 after 2000 cycles, which provides a solid base for the advanced sodium dual‐ion batteries (SDIBs) (310 Wh kg−1/7720 W kg−1). Besides, the relative pouch‐type SDIB can drive a vacuum cleaner model with an electric machine. This work may shed light on an up‐and‐coming strategy of robust cathodes for SDIBs.
Sensory processing in 16p11.2 deletion and 16p11.2 duplication
Authors: Smith Harriet , Lane Chloe , Al‐Jawahiri Reem , Freeth Megan 
Published: September 2022

AbstractDeletions and duplications at the chromosomal region of 16p11.2 have a broad range of phenotypic effects including increased likelihood of intellectual disability, autism, attention deficit hyperactivity disorder (ADHD), epilepsy, and language and motor delays. However, whether and how sensory processing is affected has not yet been considered in detail. Parents/caregivers of 38 children with a 16p11.2 deletion and 31 children with a 16p11.2 duplication completed the Sensory Behavior Questionnaire (SBQ) and the Child Sensory Profile 2 (CSP‐2) along with other standardized questionnaires assessing autistic traits (SRS‐2), ADHD traits (Conners 3), anxiety (SCAS‐P) and adaptive behavior (VABS‐3). SBQ and CSP‐2 responses found that sensory processing differences were clearly evident in both 16p11.2 deletion and 16p11.2 duplication, though there was significant variation in both cohorts. SBQ data indicated the frequency and impact of sensory behavior were more severe when compared to neurotypical children, with levels being similar to autistic children. CSP‐2 data indicated over 70% of children displayed clear differences in sensory registration (missing sensory input). Seventy‐one percent with 16p11.2 duplications were also unusually sensitive to sensory information and 57% with 16p11.2 duplications were unusually avoidant of sensory stimuli. This first detailed assessment of sensory processing, alongside other clinical features, in relatively large cohorts of children with a 16p11.2 deletion and 16p11.2 duplication demonstrates that sensory processing differences have a profound impact on their lives.
Firm‐level energy and carbon performance: Does sustainable investment matter?
Authors: Atif Muhammad , Alam Md Samsul , Islam Md Shahidul 
Published: September 2022

AbstractPollution reduction is one of the important challenges confronting contemporary business and society. Firms are largely responsible for undertaking sustainable business practices and initiatives as they are major contributors to global pollution. This study empirically examines how sustainable investment influences firm energy and carbon performance. Using a sample of 23,501 firm‐year observations from 2440 unique firms over the period of 2002 to 2018 in G‐6 countries (Canada, France, Germany, Japan, the United Kingdom, and the United States), we demonstrate that sustainable investment leads to better energy and carbon performance without compromising financial return. Our findings are robust to alternative variables, sub‐samples, and different estimation techniques. This study contributes to the global discussion on sustainability and a low‐carbon economy.
Handling customer green pressures: The mediating role of process innovation among export‐oriented manufacturing industries
Authors: Nguyen Hung , Onofrei George , Yang Ying , Pham Hiep , Wiengarten Frank , Nkhoma Mathews 
Published: September 2022

AbstractMeeting customers' green requirements for manufacturing firms has been a continuing debate but with mixed results. Based on the innovation diffusion theory, this study argues that process innovation can be an important conduit to absorb customers' green pressures to enhance sustainable measures. The empirical results from 680 manufacturers in 10 different countries confirmed the relationship between the customer green pressures and sustainability performance. Initially, manufacturers might find themselves less motivated in investing environmental initiatives due to limited business performance improvements; however, process innovation can fully absorb external pressures and enhance business measures such as growth and market share. Furthermore, as firms engage more in exports, environmental customer pressures intensify and in turn influence process innovation. Export developments led to proactive approach in handling customer green pressures and leading to better sustainable measures, mainly in environmental measures, but not financial performance. The findings highlight the importance of process innovation in sustainability development and offer managerial guidelines for export‐oriented industries in aligning customer environmental demands to accommodate resources for development of sustainable strategies.
Development of nintedanib nanosuspension for inhaled treatment of experimental silicosis
Authors: Andrade da Silva Luisa Helena , Vieira Juliana Borges , Cabral Marianna Ribeiro , Antunes Mariana Alves , Lee Daiheon , Cruz Fernanda Ferreira , Hanes Justin , Rocco Patricia Rieken Macedo , Morales Marcelo Marcos , Suk Jung Soo 
Published: September 2022

AbstractSilicosis is an irreversible and progressive fibrotic lung disease caused by massive inhalation of crystalline silica dust at workplaces, affecting millions of industrial workers worldwide. A tyrosine kinase inhibitor, nintedanib (NTB), has emerged as a potential silicosis treatment due to its inhibitory effects on key signaling pathways that promote silica‐induced pulmonary fibrosis. However, chronic and frequent use of the oral NTB formulation clinically approved for treating other fibrotic lung diseases often results in significant side effects. To this end, we engineered a nanocrystal‐based suspension formulation of NTB (NTB‐NS) possessing specific physicochemical properties to enhance drug retention in the lung for localized treatment of silicosis via inhalation. Our NTB‐NS formulation was prepared using a wet‐milling procedure in presence of Pluronic F127 to endow the formulation with nonadhesive surface coatings to minimize interactions with therapy‐inactivating delivery barriers in the lung. We found that NTB‐NS, following intratracheal administration, provided robust anti‐fibrotic effects and mechanical lung function recovery in a mouse model of silicosis, whereas a 100‐fold greater oral NTB dose given with a triple dosing frequency failed to do so. Importantly, several key pathological phenotypes were fully normalized by NTB‐NS without displaying notable local or systemic adverse effects. Overall, NTB‐NS may open a new avenue for localized treatment of silicosis and potentially other fibrotic lung diseases.
Environmental conditions during glycerol bioconversion affect 3‐hydroxypropionic acid bioproduction byLimosilactobacillus reuteriDSM17938
Authors: Nguyen Thi‐Lan‐Phuong , Béal Catherine , Ghorbal Sarrah , Saulou‐Bérion Claire 
Published: September 2022

Abstract3‐Hydroxypropionic acid (3‐HP) is a platform molecule whose biological production was carried out by the bacteriumLimosilactobacillus reuteriaccording to a two‐step process: first, a growth phase in batch mode on glucose, then a glycerol bioconversion into 3‐HP in fed‐batch mode. With the objective of improving 3‐HP bioproduction, this study aimed at defining the operating conditions during the bioconversion phase that increases the bioproduction performance. A central composite rotatable design allowed testing various pH levels and specific glycerol feeding rates. By establishing response surfaces, optimal conditions have been identified that were different depending on the considered output variable (final 3‐HP quantity, 3‐HP production yield and production rate). Of them, 3‐HP final quantity and 3‐HP production yield were maximized at pH 6.0 and at specific glycerol feeding rates of 60 and 55 mggly gCDW−1 h−1, respectively. The specific 3‐HP production rate was the highest at the upper limit of the specific substrate feeding rate (80 mggly gCDW−1 h−1) but was not affected by the pH. An additional experiment was carried out at pH 6.0 and a specific glycerol feeding rate of 80 mggly gCDW−1 h−1to validate the previous observations. In conclusion, the results showed a significant improvement of 3‐HP concentration by 13%, of specific production rate by 34% and of 3‐HP volumetric productivity by 39%, as compared to the initial values.
Results from the IMpower132 China cohort: Atezolizumab plus platinum‐based chemotherapy in advanced non‐small cell lung cancer
Authors: Lu Shun , Fang Jian , Wang Ziping , Fan Yun , Liu Yunpeng , He Jianxing , Zhou Jianying , Hu Jie , Xia Jinjing , Liu Wenxin , Shi Jane , Yi Jing , Cao Lejie 
Published: September 2022

AbstractBackgroundThe global Phase III IMpower132 study evaluating atezolizumab plus pemetrexed and carboplatin or cisplatin (APP) versus pemetrexed plus carboplatin or cisplatin (PP) for first‐line treatment of non‐squamous advanced non‐small cell lung cancer (NSCLC) met its co‐primary progression‐free survival (PFS) endpoint at the primary analysis in the intention‐to‐treat (ITT) population. Although the co‐primary overall survival (OS) endpoint was not met, numerical OS improvement favoring APP over PP was observed at the final analysis. We report primary results for Chinese patients in IMpower132.MethodsTreatment‐naive Chinese patients with non‐squamous stage IV EGFR/ALK mutation‐negative NSCLC were randomized 1:1 to receive 4 or 6 cycles of APP or PP, followed by maintenance atezolizumab plus pemetrexed or pemetrexed. Co‐primary endpoints were investigator‐assessed PFS and OS.ResultsThe ITT population included 163 Chinese patients (82 in the APP arm and 81 in the PP arm). At data cutoff (median follow‐up, 11.7 months), the median PFS in the APP and PP arms was 8.3 and 5.8 months, respectively; the unstratified hazard ratio (HR) was 0.73 (95% CI: 0.50, 1.08). At the interim OS analysis, median OS was not estimable in either arm; the unstratified HR was 0.70 (95% CI: 0.40, 1.24). No new safety signals were observed.ConclusionAmong Chinese patients in IMpower132, PFS benefit was seen with APP versus PP. Though interim OS data were immature, there was a trend toward OS benefit favoring APP versus PP. The safety profile of the APP was consistent with the known risks of the individual treatment components. ClinicalTrials.gov: NCT02657434.
Japanese subgroup analysis of EV‐301: An open‐label, randomized phase 3 study to evaluate enfortumab vedotin versus chemotherapy in subjects with previously treated locally advanced or metastatic urothelial carcinoma
Authors: Matsubara Nobuaki , Yonese Junji , Kojima Takahiro , Azuma Haruhito , Matsumoto Hiroaki , Powles Thomas , Rosenberg Jonathan E. , Petrylak Daniel P. , Matsangou Maria , Wu Chunzhang , Campbell Mary , Yamashiro Mayumi 
Published: September 2022

AbstractBackgroundEnfortumab vedotin (EV) is an antibody‐drug conjugate showing significant overall survival (OS) benefit versus chemotherapy for patients with previously treated locally advanced or metastatic urothelial carcinoma (la/mUC) in EV‐301. This subgroup analysis was conducted to further analyze the efficacy and safety in a Japanese population.MethodsIn the open‐label, phase 3 EV‐301 trial, patients with la/mUC were randomized 1:1 to EV 1.25 mg/kg on Days 1, 8, and 15 for 28‐day cycles or investigator‐preselected standard chemotherapy (SC; docetaxel or paclitaxel for patients in Japan) on Day 1 of each 21‐day cycle. Primary endpoint was OS and secondary efficacy endpoints included progression‐free survival (PFS) and overall response rate (ORR). Safety/tolerability was also evaluated.ResultsAs of the July 15, 2020 cut‐off date for the interim analysis, the Japanese subgroup included 86 patients (EV: n = 36; SC: n = 50). Median OS was 15.18 months for EV and 10.55 months for SC (HR: 0.437 [95% CI: 0.209, 0.914]). Median PFS was 6.47 months for EV and 5.39 months for SC (HR: 0.464 [95% CI: 0.258, 0.835]). Confirmed ORR was 34.4% for EV and 21.3% for SC. A higher proportion of patients receiving SC versus EV had treatment‐related adverse events (TRAEs; 97.9% vs. 91.7%, respectively), including grade ≥ 3 TRAEs (75.0% vs. 63.9%).ConclusionsThis subgroup analysis confirmed that EV, with consistent efficacy and safety/tolerability in the EV‐301 Japanese subgroup and overall study population, represents an important treatment option for previously treated patients with la/mUC.
Ixazomib combined with lenalidomide and dexamethasone chemotherapy for newly diagnosed multiple myeloma in China—Compared with bortezomib/lenalidomide/dexamethasone
Authors: Huo Zhongjun , Chen Fang , Liu Ping , Luo Zimian 
Published: September 2022

AbstractBackgroundTo compare the response and safety of Ixazomib/Lenalidomide/Dexamethasone (IRd) and Bortezomib/Lenalidomide/Dexamethasone (VRd) treatment in newly diagnosed multiple myeloma (MM).MethodsThis was a single‐center retrospective analysis in Xiangtan Central Hospital. A total of 52 newly diagnosed MM patients from June 2019 to June 2021 were enrolled and divided into the IRd (n = 21) and VRd (n = 31) groups. After 4 cycles of chemotherapy, the best response and adverse events were recorded. Moreover, the progression‐free survival (PFS) and overall survival (OS) were calculated.ResultsPatients in IRd group and VRd group showed similar PFS (Log‐rank p = 0.70), OS (Log‐rank p = 0.61) and overall response rate (83.87% vs 90.48%, p = 0.803). In addition, patients in VRd group showed lower Eastern Cooperative Oncology Group scores (p = 0.047), and higher incidence of peripheral sensory neuropathy (0.00% vs 19.35%, p = 0.032) than that of patients in IRd group.ConclusionCompared to VRd regimen, IRd had the similar efficacy, better safety, and may be more convenient for patients with poor basic condition for newly diagnosed MM. This study provides an insight for physicians to use IRd as first‐line treatment in MM.