bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decoding individual differences in self-prioritization from the resting-state functional connectome
Authors: Zhang Yongfa , Wang Fei , Sui Jie 
Published: November 2022

Abstract
Although the self has traditionally been viewed as a higher-order mental function by most theoretical frameworks, recent research advocates a fundamental self hypothesis, viewing the self as a baseline function of the brain embedded within its spontaneous activities. This hypothesis has been behaviorally established by observed self-biased effects, but its neural embeddedness remains uncorroborated. To provide a test, we investigated the association between spontaneous neural connectivity and robust self-prioritization in a perceptual matching task using task-irrelevant functional magnetic resonance imaging in 348 participants. By decoding whole-brain connectivity patterns, the support vector regression model successfully predicted the magnitude of behavioral self-prioritization, supporting the fundamental self hypothesis. The functional connectivity among default mode, cognitive control, and salience networks served as prominent neuromarkers of self-biased behavior. We further proposed a fundamental self-network model that portrays the brain mechanisms by which the self emerges internally and regulates responses to the external environment.
Electric field-induced interfacial instability in a ferroelectric nematic liquid crystal
Authors: Máthé Marcell , Farkas Bendegúz , Péter László , Buka Ágnes , Jakli Antal , Salamon Peter 
Published: November 2022

Abstract
Studies of sessile droplets and fluid bridges of a ferroelectric nematic liquid crystal in externally applied electric fields are presented. It is found that above a threshold a fingering instability occurs, resembling to Rayleigh-type instability observed in charged droplets in electric fields or circular drop-type instabilities observed in ferromagnetic liquids in magnetic field. The frequency dependence of the threshold voltage was determined in various geometries. The nematic director and ferroelectric polarization direction was found to point along the tip of the fingers that appear to repel each other, indicating that the ferroelectric polarization is essentially parallel to the director. The results are interpreted in analogy to the Rayleigh and circular drop-type instabilities.
Trauma-specific mindfulness-based cognitive therapy for women with post-traumatic stress disorder and a history of domestic abuse: intervention refinement and a randomised feasibility trial (coMforT study)
Authors: Lewis Natalia V , Gregory Alison , Feder Gene S , Angill-Williams Aishlyn , Bates Sophie , Glynn Joel , Halliwell Gemma , Hawcroft Claire , Kessler David , Lawton Michael , Leach Rwth , Millband Sarah , Pitt Katherine , Zammit Stan , Malpass Alice 
Published: November 2022

AbstractBackground:Women who have experienced domestic violence and abuse (DVA) are at increased risk of developing post-traumatic stress disorder (PTSD) and complex PTSD (CPTSD). In 2014-15, we developed a prototype trauma-specific mindfulness-based cognitive therapy curriculum (TS-MBCT) for the treatment of PTSD in a DVA population. This study aimed to refine the prototype TS-MBCT and evaluate the feasibility of conducting a randomised controlled trial (RCT) testing its effectiveness and cost-effectiveness.Methods:Intervention refinement phase was informed by evidence synthesis from a literature review, qualitative interviews with professionals and DVA survivors, and a consensus exercise with experts in trauma and mindfulness. We tested the refined TS-MBCT intervention in an individually randomised parallel group feasibility trial with pre-specified progression criteria, a traffic light system, and embedded process and health economics evaluations.Results:The TS-MBCT intervention consisted of eight group sessions and home practice. We screened 109 women in a DVA agency and recruited 20 (15 TS-MBCT, 5 self-referral to National Health Service (NHS) psychological treatment), with 80% follow-up at 6 months. Our TS-MBCT intervention had 73% uptake, 100% retention, and high acceptability. Participants suggested recruitment via multiple agencies, and additional safety measures. Randomisation into the NHS control arm did not work due to long waiting lists and previous negative experiences. Three self-administered PTSD/CPTSD questionnaires produced differing outcomes thus a clinician administered measure might work better. We met six out of nine feasibility progression criteria at green and three at amber targets demonstrating that it is possible to conduct a full-size RCT of the TS-MBCT intervention after making minor amendments to recruitment and randomisation procedures, the control intervention, primary outcomes measures, and intervention content. At 6 months, none of the PTSD/CPTSD outcomes ruled out a clinically important difference between trial arms indicating that it is reasonable to proceed to a full-size RCT to estimate these outcomes with greater precision.Conclusions:A future RCT of the coMforT TS-MBCT intervention should recruit from multiple DVA agencies, NHS and non-NHS settings, have an active control psychological treatment, use robust randomisation and safety procedures, and clinician-administered measures for PTSD/CPTSD.Trial registration: ISRCTN64458065 11/01/2019, https://www.isrctn.com/ISRCTN64458065?q=64458065&filters=&sort=&offset=1&totalResults=1&page=1&pageSize=10
Characterization and the comprehensive expression analysis of tobacco valine-glutamine genes in response to trichomes development and stress tolerance
Authors: Yan Xiaoxiao , Luo Rui , Liu Xiangyang , Hou Zihang , Pei Wenyi , Zhu Wenqi , Cui Hong 
Published: November 2022

Abstract
Valine-glutamine genes (VQ) acted as transcription regulators and played the important roles in plant growth and development, and stress tolerance through interacting with transcription factors and other co-regulators. In this study, sixty-one VQ genes containing the FxxxVQxxTG motif were identified and updated in the Nicotiana tobacum genome. Phylogenetic analysis indicated that NtVQ genes were divided into seven groups and genes of each group had highly conserved exon-intron structure. Expression patterns analysis firstly showed that NtVQ genes expressed individually in different tobacco tissues including mixed-trichome (mT), glandular-trichome (gT), and nonglandular-trichome (nT), and the expression levels were also distinguishing in response to methyl jasmonate (MeJA), salicylic acid (SA), gibberellic acid (GA), ethylene (ETH), high salinity and PEG stresses. Besides, only NtVQ17 of its gene family was verified to have acquired autoactivating activity. This work will not only lead a foundation on revealing the functions of NtVQ genes in tobacco trichomes but also provided references to VQ genes related stress tolerance research in more crops.
Cyclophosphamide combined with methylprednisolone can play a therapeutic role by delaying the aging of pulmonary fibrosis
Authors: Xu Qingjie , Zhang Manka , Tang Ming , Li Zhouping , Liu Yin , ma Tao , Rao Zhiguo , Yang Keyu , He Xiaoxu , Ma Runlin , Xue Xiaoyan 
Published: November 2022

Abstract
Background: Aging is a natural process characterized by a progressive functional impairment and reduced capacity to respond adaptively to environmental stimuli.Idiopathic pulmonary fibrosis(IPF)has been found to increase considerably with age.Immunosenescence,oxidative stress,abnormal shortening of telomeres, apoptosis, and epigenetic changes affecting gene expression have been proposed to contribute to the aging process,and aging-associated diseases. The above indicates that aging can increase the incidence of IPF. So can the occurrence of aging be aggravated after IPF? We examined pathological damage, collagen deposition, oxidative stress and immunosenescence to determine whether bleomycin(BLM)-induced pulmonary fibrosis (PF) accelerates aging in rats. If so, what drugs can inhibit or delay this aging. In clinical studies,the combination of methylprednisolone(MP) and cyclophosphamide(CTX) has shown great benefits in patients with IPF, but its effect on aging resulting from fibrosis is not fully understood. Therefore, we investigated whether MP combined with CTX could delay or inhibit aging in IPF rats. It may provide new targets for the treatment of IPF.
Methods: PF rat models were induced by BLM and treated with MP or MP/CTX combination.Transmission electron microscope, hematoxylin and eosin (H&E) and Masson staining were used to measure the morphology of PF. α-SMA and collagen I levels were examined by western blot and immunohistochemistry. Malondialdehyde(MDA),myeloperoxidase(MPO),lutathione peroxidase(GSH-PX) and superoxide dismutase(SOD) levels were determined using commercial kits.T cells were analyzed with flow cytometry.
Results: We found that pathological damage, collagen deposition, oxidative stress, and T-cell senescence were increased after BLM-induced PF. The combined use of MP and CTX can alleviate pathological damage, reduce oxidative stress response, such as reducing MDA and MPO levels, and increasing SOD and GSH-PX activities. And inhibition of T cell senescence in lung tissue, such as reduction of CD27-CD28- CD4+ T cells in BLM-induced PF.
Conclusions: BLM-induced PF aggravated the occurrence of aging in rats. The combination of MP and CTX can inhibit or delay aging, and thus play a therapeutic role in IPF.These findings provide new insights into the mechanism by which MP and CTX act in combination on IPF.
A Below Ground Chemical Fight for Phosphate and Habitat - Interactions of Camelina sativa (L.) Crantz with Microorganisms
Authors: Schulz Margot , Hofmann Diana , Thiele Björn , Rahmati Mehdi , Siebers Meike , Schütz Vadim , Jeong Seungwoo , Bigler Laurent , Held Federico , Wu Bei , Babic Nikolina , Kovacic Filip , Hamacher Joachim , Hölzl Georg , Dörmann Peter 
Published: November 2022

Abstract

BACKGROUND and AIMS

Glucosinolates and isothiocyanates of young Camelina sativa (L.) Crantz can eliminate microbial species in the soil. It was aimed to demonstrate that only isothiocyanate insensitive microorganisms with phosphate solubilizing activity can be successfully used to improve the plant´s phosphate supply.

METHODS

We performed rhizotron growth studies and 33P–Imaging to study the uptake of phosphate solubilized from 33P-apatite by inoculated plants and determined the phosphate solubilization capacities of microorganisms by inductively coupled plasma mass spectrometry. Secondary metabolites of Camelina sativa and of the soil fungus Penicillium aurantiogriseum were analyzed by HPLC-MS/MS. Microorganisms and plant seedlings were cultured for growth inhibition studies. Phospholipid fatty acids in soil samples were investigated by gas chromatography and the data analyzed by clustering and principal component analysis.

RESULTS

1. The inoculants Trichoderma viride and Pseudomonas laurentiana did not improve the phosphate uptake of Camelina sativa and Abutilon theophrasti.
2. The intrinsic soil microorganisms, including Penicillium aurantiogriseum, the inoculants and the assemblies of root colonizing microorganisms are able to solubilize phosphate from apatite and compete for phosphate.
3. Camelina´s glucosinolates and derived isothiocyanates and, as well secondary metabolites released by P. aurantiogriseum, particularly cyclo-(L-Leu-L-Pro), have the capacity to suppress plant and fungal growth and to destroy a phosphate solubilizing bacterial consortium that colonizes Camelina roots.
4. Loss of young Camelina´s key secondary metabolites, the glucosinolates, is of advantage for fungi, as verified by a green manure experiment.

CONCLUSION

The results underline functions of secondary metabolites when organisms are under competive conditions for phosphate uptake.
Ectopic overexpression of GRK5 promotes malignant glioma progression closely associated with MSN-CD44 expression and glioma localization
Authors: Yang Yang , Xi Zhiyu , Wu Jing-Jing , Ni Shengyuan , Ling Shiying 
Published: November 2022

Abstract
Background
Gliomas are highly invasive and lack of effective targeted therapy. GRK5 is involved in several pathologic conditions including cancer. GRK5 phosphorylated MSN on T66 and regulated the subcellular distribution of MSN, which was a glioma progression marker that induces proliferation via interaction with CD44. Therefore, targeting GRK5-MSN-CD44 may provide a novel approach for the treatment of gliomas.
Materials and methods
GRK5-knockdown and GRK5-upregulated glioma cell lines were generated by using the lentivirus transfection method. The GRK5 and MSN expression and the association with the malignant characters in glioma were determined by Western blot and qRT-PCR. By using double-immunofluorescence and triple immunofluorescence analysis, the subcellular localization and distribution characteristics of GRK5-MSN-CD44 in gliomas were detected. The cell proliferation, migration, invasion and apoptosis were determined by CCK-8 assay, wound healing assay, transwell assay and flow cytometry respectively.
Results
GRK5 expression was up-regulated in human gliomas and positively correlated with MSN expression. GRK5-MSN and MSN-CD44 were found co-expressed in gliomas respectively. GRK5-MSN-CD44 were co-localized in the membrane of glioma cell and abundant in glioma stem cell niches. VEGF and N-cadherin expressions were increased/decreased according to the up-regulation/down-regulation of GRK5. And Bax expression showed decreased/increased according to GRK5 over-expression/low-expression. The proliferation, migration and invasion of glioma cells were improved due to the upregulation of GRK5. And the apoptosis of glioma cells was decreased/increased due to the up-regulation/down-regulation of GRK5.
Conclusion
Ectopic overexpression of GRK5 promoted the malignant progression of glioma and is closely related to MSN-CD44 interaction. GRK5-MSN-CD44 provides a new idea for gene targeted therapy of glioma.
A European measurement scale for material deprivation
Authors: Farcomeni Alessio , Pittau Maria Grazia , Viviani Sara , Zelli Roberto 
Published: November 2022

AbstractThe predominant practice of establishing a material deprivation scale as the raw sum of a relatively small set of binary items has obvious returns in terms of communication and simplicity of use. However, it can be misleading when basic measurement properties are not met. Only within the Rasch measurement approach, these requirements can be properly addressed. In Rasch models, material deprivation is treated as an unobservable numerical variable (latent trait) that can be inferred from a set of observable items, each representing a different aspect of the same latent trait. Based on Rasch model analytical procedure and using the Survey on Income and Living Conditions (EU-SILC) pre-Covid data, this paper develops a European measurement reference scale for material deprivation which ensures validity and comparability across different countries. Specifically, from a pool of potential items, we introduce a stochastic method to select the largest number of items that guarantee the property of uni-dimensionality of the latent trait, not necessarily ensured by the Rasch model. We also adjust for possible differential item functioning (DIF) to better ensure comparability of the scale across European countries. We finally estimate prevalence rates of material deprivation in 28 European countries. Prevalence rates estimated using the traditional counting approach substantially differ from the figures estimated with the new measurement scale when DIF occurs.
Seasonal monitoring of river and lake water surface areas at global scale with deep learning
Authors: Carbonneau Patrice , Bizzi Simone 
Published: November 2022

Abstract
Much progress has been made over the last decade to build global inventories of freshwater resources. However, existing freshwater inventories are generally produced for a fixed period in time and/or do not discriminate lakes and rivers. The emergence of deep learning methods and Big Data platforms such as Google Earth Engine offers a potential solution. Here we presenta unique global raster dataset of 6.7 terapixels at a spatial resolution of 10 m produced with a deep learning workflow. This dataset uses Sentinel-2 imagery downloaded from Google Earth Engine to delineatefreshwater as separate semantic classes of rivers and lakes. Ourstudy site covers the non-polar globe, 89% of the terrestrial landmass, with repeat surveys for the months of April, July and October 2021. This gives us the first global-scale direct count of lakes larger than 1 hectare as ~7.3 million. Also the repeat surveys allow us topresent the firstintra-annual ranges for the areas distinctly occupied by rivers and lakes where we find that basins influenced by the Asian summer monsoon (e.g. the Ganges) closely followed by the Amazon display the largest intra-annual range of river area per unit basin area. Finally, we find that whilst maximum of lake water surface occurs in October 2021, the maximum river surfaceis in July 2021 leading us to conclude that the global maximum occurrences of river waterand lake water are not synchronous.
Sources of Wage Inequality: Decomposing the Conditional Gini Coefficient
Authors: Hurtado Carlos 
Published: November 2022

Abstract
I develop an econometric method to determine the characteristics that affect the disparity in the distribution of a positive random variable, e.g., income or wages. I relate the conditional Lorentz curve to the conditional quantile function to decompose the conditional Gini index. The proposed procedure uses polynomial approximations of the estimates of the conditional quantile regression coefficients to decompose the factors and characteristics that contribute most to the inequality of the distribution of the random variable. Moreover, this paper proposes a technique to disentangle the temporal changes in the distribution. I demonstrate the use of the method using U.S. hourly wages for the years 1986 and 2015. I find that increases in the proportion of workers with high school and associate degrees are significantly correlated to reductions in inequality of the wage distribution in the U.S. during the analysis period.
JEL Classification Numbers: C13, C21, C43, D63
The causal mutation in ARR3 gene for high myopia and progressive color vision defect
Authors: Gu Lei , Cong Peikuan , Ning Qingyao , Jiang Bo , Wang Jianyong , Cui Hongguang 
Published: November 2022

Abstract
The ARR3 gene, also known as cone arrestin, belongs to the arrestin family and is expressed in cone cells, inactivating phosphorated-opsins and preventing cone signals. Variants of ARR3 reportedly cause X-linked dominant female-limited early-onset (age < 7 years old) high myopia (<-6D). Here, we reveal a new mutation (c.228T>A, p.Tyr76*) in ARR3 gene that can cause early-onset high myopia (eoHM) limited in female carriers, and protan/deutan color vision defect affecting both genders. Using ten years of clinical follow-up data, we identified gradually worsen cone dysfunction/color vision as a key feature among affected individuals. We present a hypothesis of unbalanced color-vision signal output that had lowered blue color contribution from cone cells could potentially explain the etiology of this disease.
A head-to-head comparison of Well-being of Older People (WOOP) and EQ-5D-5L in patients, carers and general public in China
Authors: Ran Xun , Mao Zhuxin , Yang Zhihao 
Published: November 2022

Abstract
Introduction:
Recently, Well-being of Older People measure (WOOP) was developed and validated in a Dutch population. Although WOOP was developed targeting the older people, it has the potential for use in a wider population. In this study, we aimed to examine the relationship between WOOP and EQ-5D-5L and compared their psychometric properties in a sample of patients, carers and healthy general public covering a wider age group.
Method:
We conducted a cross-sectional study in Guizhou Province, China between July and August 2022. Data was collected using paper and pencil. We analysed and reported the acceptability, item response distribution, the Spearman correlation coefficients of all items, the Exploratory Factor Analysis (EFA) of all items, the known-group validity and the convergent validity of EQ-5D-5L utility and WOOP utility.
Results:
A total of 322 participants completed the survey with 105 patients, 101 carers and 116 healthy general public. 9% of participants had at least one missing response. Three items of WOOP did not have any level 5 responses and EQ-5D-5L had more level 1 responses. The correlations were low between EQ-5D-5L and WOOP items and the three-factor EFA showed these two instruments had only one shared factor and the other two factors were only related to WOOP items. Younger people had lower missing response rate and a different response distribution for three items.
Discussion:
WOOP measures a broader construct beyond health while EQ-5D-5L is a more sensitive instrument when health is considered alone. There is a potential of using WOOP in a wider population.
Tools for Assessing Professional Identity in Health Profession Education: A Scoping Review
Authors: Tabatabaei Zahra Sadat , Amini Homayoun , Mafinejad Mahboobeh Khabaz 
Published: November 2022

Abstract
Background
Learning about the formation and development of professional identity and its principled planning in universities play an essential role in the development of the identity of individuals in educational and professional environments. Although the formation and development of identity is the main goal of Health Profession Education, due to the complexity of this process and its multidimensional nature, appropriate measurement and evaluation criteria are not readily available. To address this gap, a scoping review was conducted to explore current knowledge in assessing professional identity and map directions for future research.
Methods
The present scoping review was conducted based on the five-step framework of Arksey and O'Malley. At first, the research question was formulated. Then, PubMed, Eric, ProQuest, Scopus databases and Google scholar search engine were systematically searched until September 2022. The two authors independently selected all articles based on screening eligibility criteria and charted the data. Finally, the eligible articles were analyzed using descriptive analysis of studies on the characteristics and psychometrics of the tools and their underlying theories.
Results
After extensive searching 9,924 studies were identified. 162 studies were selected for full-text review of which 17 articles were eligible to be included. More than half of the articles were from England and Japan. Most of the target group was studies on nursing and medical students. In 14 studies included, tools and psychometric properties were mentioned. Several theories were used to develop professional identity assessment tools. Identity theories were the basis for designing or developing most tools. In identity theories, social identity theory and Kagan's constructive-developmental theory were used more than others.
Conclusions
The results of this scoping review will help researchers to choose or develop reliable and valid tools in accordance with clear conceptual and theoretical frameworks to measure and evaluate the formation and development of professional identity in Health Profession Education. Developing comprehensive tools that underpin the appropriate conceptual framework provides the possibility of evaluating the continuous and nonlinear process of the formation and development of professional identity which can be implemented at a large scale.