bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ukraine's Experience with Management of Combat Casualties Using NATO's Four‐Tier “Changing as Needed” Healthcare System
Authors: Kazmirchuk Anatoliy , Yarmoliuk Yurii , Lurin Igor , Gybalo Rostislav , Burianov Olexandr , Derkach Serhii , Karpenko Kostiantyn 
Published: September 2022

AbstractIntroductionThe full‐scale war with Russia on the territory of Ukraine has revealed several problems related to care of the wounded. In this article, we summarize the mechanisms of injury and injuries sustained for the period February to April 2022, focusing on extremity injuries.Materials and methodsWe compared these to a period of lower‐intensity warfare in 2014–2021. In both cases, we report patients treated by the National Military Medical Clinical Center (NMMCC) in Kyiv. We also sought to evaluate the care of the wounded from an organizational viewpoint, taking into account the four‐level system of care also used by the North Atlantic Treaty Organization (NATO). Third, we sought to understand lessons learned that could improve the care of the wounded.ConclusionDuring the 2022 conflict, the percentage of patients with extremity wounds who had long bone fractures increased and the percentage of people with long bone fractures who had bone defects increased, compared with 2014–2021. This may be due to the higher blast energy from the weapons used in the current conflict. Second, we adapted the four‐level NATO system of care. Level 2 (first level hospital) care was provided by civilian hospitals close to the fighting, rather than mobile military hospitals. Level 3 (specialized) and 4 (highly specialized) care were combined into one hospital (NMMCC). This is the first description of flexible use of NATO's four levels. Finally, a major lesson learned was the need to improve use of damage control surgery.
Did medical doctors who order abdominal CT scans during on-call hours truly become worse at clinical reasoning? Yes, they did
Authors: Ersoydan Selin , Yakar Derya , Kasalak Ömer , Kwee Thomas C. 
Published: September 2022

Abstract
Objective
To investigate temporal changes in clinical reasoning quality of physicians who requested abdominal CT scans at a tertiary care center during on-call hours within a 15-year period.

Methods
This retrospective study included 531 patients who underwent abdominal CT at a tertiary care center during on-call hours on 36 randomly sampled unique calendar days in each of the years between 2005 and 2019. Clinical reasoning quality was expressed as a percentage (0–100%), taking into account the degree by which the differential diagnoses on the CT request form matched the CT diagnosis. Temporal changes in the quality of clinical reasoning and number of CT scans were assessed using Mann-Kendall tests. Associations between the quality of clinical reasoning with patient age and gender, requesting department, and time of CT scanning were determined with linear regression analyses.

Results
The median annual clinical reasoning score was 14.7% (interquartile range: 12.2 to 16.0%; range: 7.7 to 34.6%). The quality of clinical reasoning significantly decreased between 2005 and 2019 (Mann-Kendall Tau of −0.390, p = 0.048), while the number of abdominal CT scans significantly increased (Mann-Kendall tau of 0.790, p < 0.001).

Conclusion
The clinical reasoning quality of physicians who request abdominal CT scans during on-call hours has deteriorated over time. Clinical reasoning appears to be worse in younger patients.

Key Points
• In patients with suspected acute abdominal pathology who are scheduled to undergo CT scanning, referring physicians generally have difficulties in making an accurate pretest (differential) diagnosis.
• Clinical reasoning quality of physicians who request acute abdominal CT scans has deteriorated over the years, while the number of CT scans has shown a significant increase.
• Clinical reasoning quality appears to be worse in younger patients in this setting.
Hyperplane patch mixing-and-folding decoder and weighted chamfer distance loss for 3D point set reconstruction
Authors: Furuya Takahiko , Liu Wujie , Ohbuchi Ryutarou , Kuang Zhenzhong 
Published: September 2022

Abstract3D point set reconstruction is an important and challenging 3D shape analysis task. Current state-of-the-art algorithms for 3D point set reconstruction employ a deep neural network (DNN) having an encoder–decoder architecture. Recently, the decoder DNNs that transform multiple 2D planar patches to reconstruct a 3D shape have seen some success. These “patch-folding” decoders are adept at approximating smooth surfaces in 3D objects. However, 3D point sets generated by these decoders often lack local geometrical details, as 2D planar patches tend to overly constrain the patch folding process. In this paper, we propose a novel decoder DNN for 3D point sets called Hyperplane Mixing and Folding Net (HMF-Net). HMF-Net uses less constrained hyperplane, not 2D plane, patches as its input to the folding process. HMF-Net has, as its core building block, a stack of token-mixing layers to effectively learn global consistency among the hyperplane patches. In addition to HMF-Net, we also propose a novel loss for 3D point set reconstruction called Weighted Chamfer Distance (WCD). WCD tries to weight, or amplify, loss from parts of shape that are highly variable across training samples by emphasizing higher point-pair distance values between a generated point set and a groundtruth point set. This helps the decoder DNN learn shape details better. We comprehensively evaluate our algorithm under three 3D point set reconstruction scenarios, that are, shape completion, shape upsampling, and shape reconstruction from 2D images. Experimental results demonstrate that our algorithm yields accuracies higher than the existing algorithms for 3D point set reconstruction.
Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma
Authors: Siddaway Robert , Canty Laura , Pajovic Sanja , Milos Scott , Coyaud Etienne , Sbergio Stefanie-Grace , Vadivel Anguraj Arun Kumaran , Lubanszky Evan , Yun Hwa Young , Portante Alessia , Carette Sheyenne , Zhang Cunjie , Moran Michael F. , Raught Brian , Campos Eric I. , Hawkins Cynthia 
Published: September 2022

AbstractHistone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of H3K27me3 through dominant negative PRC2 inhibition, while H3G34R mutations lead to local losses of H3K36me3 through inhibition of SETD2. However, their broader oncogenic mechanisms remain unclear. We characterized the H3.1K27M, H3.3K27M and H3.3G34R interactomes, finding that H3K27M is associated with epigenetic and transcription factor changes; in contrast H3G34R removes a break on cryptic transcription, limits DNA methyltransferase access, and alters mitochondrial metabolism. All 3 mutants had altered interactions with DNA repair proteins and H3K9 methyltransferases. H3K9me3 was reduced in H3K27M-containing nucleosomes, and cis-H3K9 methylation was required for H3K27M to exert its effect on global H3K27me3. H3K9 methyltransferase inhibition was lethal to H3.1K27M, H3.3K27M and H3.3G34R pHGG cells, underscoring the importance of H3K9 methylation for oncohistone-mutant gliomas and suggesting it as an attractive therapeutic target.
Exposure to work-related violence and/or threats of violence as a predictor of certified sickness absence due to mental disorders: a prospective cohort study of 16,339 Swedish men and women in paid work
Authors: Wijkander Maria , Farrants Kristin , Magnusson Hanson Linda L. 
Published: September 2022

Abstract
Objectives
The aim of this prospective cohort study was to investigate if exposure to work-related violence and/or threats of violence predict certified sickness absence due to mental disorders.

Methods
Information on work-related exposure to violence and/or threats of violence were derived from the biannual Swedish Longitudinal Occupational Survey of Health (SLOSH) study 2012–2016, including individuals in paid work across Sweden and from different occupations/sectors (n = 16,339). Certified sickness absence due to mental disorders were ascertained from register data from the Swedish Social Insurance Agency. Odds ratios of certified sickness absence due to mental disorders according to exposure to work-related violence were estimated using multiple logistic regression. Several potential confounding variables, such as demographic and socio-economic factors, age, sex, cohabitation, children living at home, socio-economic status, educational level, as well as other types of psychosocial work environmental factors, were adjusted for in the analyses.

Results
In the total study sample, 9% reported exposure to violence and/or threats of violence and the prevalence of sickness absence due to mental disorders was 5%. Exposure to work-related violence and/or threats of violence was associated prospectively with certified sickness absence due to mental disorders (odds ratio 1.46, 95% confidence interval 1.17–1.82, p < 0.01). Analysis of possible interaction showed no difference in association when comparing women to men and different age groups.

Conclusions
Exposure to work-related violence and/or threats of violence appear to increase the odds of certified sickness absence due to mental disorders. Preventive measures aiming to lower the risk of exposure is thus of great importance.
BRAF p.V600E genetic testing based on ultrasound-guided fine-needle biopsy improves the malignancy rate in thyroid surgery: our single-center experience in the past 10 years
Authors: Gong Lei , Liu Yan , Guo Xinghong , Wang Chuan , Yan Fei , Liu Jinbo , Hou Xinguo , Chen Li , Liang Kai 
Published: September 2022

Abstract
Purpose
Ultrasound-guided fine-needle aspiration biopsy (UG-FNAB) was implemented in Qilu Hospital of Shandong University in 2015 as a preoperative diagnostic method for thyroid surgery. BRAF p.V600E genetic testing was implemented in 2019. This study evaluated the impact of these two tests on the malignancy rate in patients undergoing thyroidectomy.

Methods
A total of 19,496 patients were included in the study. We retrospectively collected data from patients undergoing thyroid surgery in the Hospital Information System (HIS) of Qilu Hospital of Shandong University from January 2012 to December 2021. Meanwhile, data of FNAB, UG-FNAB, and BRAF p.V600E genetic testing were collected. Differences in means among groups were analyzed via one-way ANOVA, and differences in frequencies were analyzed via Pearson’s chi-squared test.

Results
In this study, the 10-year period was divided into three stages, with the implementation of UG-FNAB in 2015 and that of BRAF p.V600E genetic testing in 2019 as dividing lines. The malignancy rate in thyroid surgery increased significantly during these three stages (48.06% vs. 73.47% vs. 88.17%; P < 0.001). In the same period (May 2019 to December 2021), the malignancy rate in thyroid surgery was significantly different between the Non-FNAB, UG-FNAB, and UG-FNAB-BRAF groups (78.87% vs. 95.63% vs. 98.32%; P < 0.001).

Conclusions
The successful implementation of UG-FNAB and BRAF p.V600E genetic testing improved the malignancy rate in thyroid surgery and reduced unnecessary diagnostic surgery for benign and marginal lesions. It can, therefore, provide a clinical reference for other hospitals.
The effect of a palliative care pathway on medical interventions at the end of life: a pre-post-implementation study
Authors: van der Padt-Pruijsten Annemieke , Leys Maria B. L. , Hoop Esther Oomen-de , van der Heide Agnes , van der Rijt Carin C. D. 
Published: September 2022

Abstract
Purpose
Adequate integration of palliative care in oncological care can improve the quality of life in patients with advanced cancer. Whether such integration affects the use of diagnostic procedures and medical interventions has not been studied extensively. We investigated the effect of the implementation of a standardized palliative care pathway in a hospital on the use of diagnostic procedures, anticancer treatment, and other medical interventions in patients with incurable cancer at the end of their life.

Methods
In a pre- and post-intervention study, data were collected concerning adult patients with cancer who died between February 2014 and February 2015 (pre-PCP period) or between November 2015 and November 2016 (post-PCP period). We collected information on diagnostic procedures, anticancer treatments, and other medical interventions during the last 3 months of life.

Results
We included 424 patients in the pre-PCP period and 426 in the post-PCP period. No differences in percentage of laboratory tests (85% vs 85%, p = 0.795) and radiological procedures (85% vs 82%, p = 0.246) were found between both groups. The percentage of patients who received anticancer treatment or other medical interventions was lower in the post-PCP period (40% vs 22%, p < 0.001; and 42% vs 29%, p < 0.001, respectively).

Conclusions
Implementation of a PCP resulted in fewer medical interventions, including anticancer treatments, in the last 3 months of life. Implementation of the PCP may have created awareness among physicians of patients’ impending death, thereby supporting caregivers and patients to make appropriate decisions about medical treatment at the end of life.

Trial registration number
Netherlands Trial Register; clinical trial number: NL 4400 (NTR4597); date registrated: 2014–04-27.
Consensus statement on smoking cessation in patients with pain
Authors: Iida Hiroki , Yamaguchi Shigeki , Goyagi Toru , Sugiyama Yoko , Taniguchi Chie , Matsubara Takako , Yamada Naoto , Yonekura Hiroshi , Iida Mami 
Published: September 2022

AbstractSmoking is closely associated with the development of various cancers and tobacco-related illnesses such as cardiovascular and respiratory disorders. However, data are scarce on the relationship between smoking and both acute and chronic pain. In addition to nicotine, tobacco smoke contains more than 4000 different compounds. Although nicotine is not the sole cause of smoking-induced diseases, it plays a critical role in pain-related pathophysiology. Despite the acute analgesic effects of nicotine, long-term exposure leads to tolerance and increased pain sensitivity due to nicotinic acetylcholine receptor desensitization and neuronal plastic changes. The purpose of smoking cessation interventions in smoking patients with pain is primarily not only to reduce their pain and associated limitations in activities of daily living, but also to improve the outcomes of underlying pain-causing conditions and reduce the risks of tobacco-related disorders. This statement aims to summarize the available evidence on the impact of smoking on pain and to inform medical professionals of the significance of smoking cessation in patients with pain.
Short versus standard implants at sinus augmented sites: a systematic review and meta-analysis
Authors: Toledano Manuel , Fernández-Romero Enrique , Vallecillo Cristina , Toledano Raquel , Osorio María T. , Vallecillo-Rivas Marta 
Published: September 2022

Abstract
Background
Short implants are proposed as a less invasive alternative with fewer complications than standard implants in combination with sinus lift. The aim of this systematic review and meta-analysis was to state the efficacy of placing short implants (≤ 6 mm) compared to standard-length implants (≥ 8 mm) performing sinus lift techniques in patients with edentulous posterior atrophic jaws. Efficacy will be evaluated through analyzing implant survival (IS) and maintenance of peri-implant bone (MBL).

Methods
Screening process was done using the National Library of Medicine (MEDLINE by PubMed), EMBASE, the Cochrane Oral Health, and Web of Science (WOS). The articles included were randomized controlled trials. Risk of bias was evaluated according to The Cochrane Collaboration’s tool. Weighted means were calculated. Heterogeneity was determined using Higgins (I2). A random-effects model was applied. Secondary outcomes such as surgical time, patient satisfaction, mucositis and peri-implantitis, pain, and swelling were analyzed.

Results
Fourteen studies (597 patients and 901 implants) were evaluated. IS was 1.02 risk ratio, ranging from 1.00 to 1.05 (CI 95%) (p = 0.09), suggesting that IS was similar when both techniques were used. MBL was higher in patients with standard-length implants plus sinus lift elevation (p = 0.03). MBL was 0.11 (0.01–0.20) mm (p = 0.03) and 0.23 (0.07–0.39) mm (p = 0.005) before and after 1 year of follow-up, respectively, indicating that the marginal bone loss is greater for standard-length implants.

Discussion
Within the limitations of the present study, as relatively small sample size, short dental implants can be used as an alternative to standard-length implants plus sinus elevation in cases of atrophic posterior maxilla. Higher MBL was observed in the groups where standard-length implants were used, but implant survival was similar in both groups. Moreover, with short implants, it was observed a reduced postoperative discomfort, minimal invasiveness, shorter treatment time, and reduced costs.

Clinical Clinical relevance
The low MBL promoted by short implants does contribute to a paradigm shift from sinus grafting with long implants to short implants. Further high-quality long-term studies are required to confirm these findings.
Modification of glass-ionomer cement properties by quaternized chitosan-coated nanoparticles
Authors: Elshenawy Enas A. , El-Ebiary Manal Ahmed , Kenawy El-Refaie , El-Olimy Gehan Abdelmonem 
Published: September 2022

AbstractGlass ionomers (GICs), because of their qualities, are in a good position to be modified to resist masticatory stresses as permanent posterior restoration and prevent recurrent caries. The purpose of the present study was to evaluate the effect of adding quaternized chitosan-coated mesoporous silica nanoparticles (HTCC@MSNs) to conventional GIC on its mechanical properties, antimicrobial activity and fluoride release and the effect of 1- and 3-month water aging on the studied properties. HTCC@MSNs was synthesized, added to commercially available conventional GIC at 1%, 3%, and 5% by weight forming three experimental groups and compared with plain GIC as a control group. Flexural strength, modulus, Vickers microhardness and wear volumes were evaluated. Antibacterial activity was tested against Streptococcus mutans and fluoride release in de-ionized water was measured. All properties were evaluated before and after one- and three-month aging (n = 10 specimens per test/per time). Two-way ANOVA was used for statistical analysis. Characterization confirmed successful preparation of HTCC@MSNs. The flexural strength, modulus, hardness and wear resistance of the GICs improved significantly by adding 1–3% HTCC@MSNs, while 5% HTCC@MSNs group showed no significant difference compared to control group. Bacterial inhibition zones and fluoride release increased proportionally to the amount of filler added. Mechanical properties were improved by artificial aging. Fluoride release values, and bacterial inhibition zones decreased with aging for all groups. HTCC@MSNs as a filler with the optimized proportion provides strengthening and antibacterial effect. In addition, aging is an important factor to be considered in evaluating experimental fillers.
How Carequality, The Sequoia Project, and eHealth Exchange Support the Interoperable Exchange of Health Data in the USA
Authors: Davis Blanca “Didi” , Swenson Alan 
Published: September 2022

AbstractEvery organization in the health IT industry plays an important role in overcoming barriers to health information exchange in the United States. It is important to understand imaging interoperability in the overall context of Health Information Exchange (HIE). The rapid evolution of storage, bandwidth and network transport technologies has made the handling of imaging data converge with the primarily text-based healthcare data. The radiology community must understand the overall environment and become a tightly integrated part of it. As the health IT ecosystems continue to evolve, it became clear that there would not be a single health information exchange network to service the nation. Rather, like other industries such as telecom and banking, there would be multiple networks that would need to interconnect. To support compliance to interoperability standards and specifications, The Sequoia Project began collaborating with industry to create testing programs and tooling that supports transport, security and content testing requirements for four production testing programs today. These testing programs validate compliance to standards for transport and security as well standards for the payloads such as clinical documents and imaging data. While once operating under the same umbrella, The Sequoia Project, Carequality and eHealth Exchange (https://ehealthexchange.org/) have been separate companies since 2018. Each plays a unique role in helping patient information move where and when it is needed, each working with a framework of standards published by IHE, DICOM, and HL7 to enable health information exchange.
Treprostinil Supplementation Ameliorates Hepatic Ischemia Reperfusion Injury and Regulates Expression of Hepatic Drug Transporters: An Isolated Perfused Rat Liver (IPRL) Study
Authors: Almazroo Omar Abdulhameed , Shaik Imam H , Hughes Christopher B , Humar Abhinav , Venkataramanan Raman 
Published: September 2022

Abstract
Purpose
IR injury is an unavoidable consequence in deceased donor liver transplantation. Cold preservation and warm reperfusion may change the expression and function of drug transporters in the liver due to vasoconstriction, infiltration of neutrophils and release of cytokines. We hypothesize that vasodilation, anti-platelet aggregation and proinflammatory downregulation activities of treprostinil will diminish the IR injury and its associated effects.

Methods
Livers obtained from male SD rats (n = 20) were divided into 1) Control, 2) IR, 3) Treprostinil-1 (preservation only), and 4) Treprostinil-2 (preservation and reperfusion) groups. Control livers were procured and immediately reperfused. Livers in the other groups underwent preservation for 24 h and were reperfused. All the livers were perfused using an Isolated Perfused Rat Liver (IPRL) system. Periodic perfusate, cumulative bile samples and liver tissue at the end of perfusion were collected. Liver injury markers, bile flow rates, m-RNA levels for uptake and efflux transporters (qRT-PCR) were measured.

Results
Cold preservation and warm reperfusion significantly increased the release of AST and ALT in untreated livers. Treprostinil supplementation substantially reduced liver injury. Bile flow rate was significantly improved in treprostinil-2 group. m-RNA levels of Slc10a1, Slc22a1, and Slc22a7 in liver were increased and m-RNA levels of Mdr1a were decreased by IR. Treprostinil treatment increased Abcb11 and Abcg2 m-RNA levels and maintained Slc22a1m-RNA similar to control livers.

Conclusions
Treprostinil treatment significantly reduced liver injury. IR injury changed expression of both uptake and efflux transporters in rat livers. Treprostinil significantly altered the IR injury mediated changes in m-RNA expression of transporters.
Isoperimetric Inequalities for the Magnetic Neumann and Steklov Problems with Aharonov–Bohm Magnetic Potential
Authors: Colbois Bruno , Provenzano Luigi , Savo Alessandro 
Published: September 2022

AbstractWe discuss isoperimetric inequalities for the magnetic Laplacian on bounded domains of $${\mathbb {R}}^2$$

R

2

endowed with an Aharonov–Bohm potential. When the flux of the potential around the pole is not an integer, the lowest eigenvalue for the Neumann and the Steklov problems is positive. We establish isoperimetric inequalities for the lowest eigenvalue in the spirit of the classical inequalities of Szegö–Weinberger, Brock and Weinstock, the model domain being a disk with the pole at its center. We consider more generally domains in the plane endowed with a rotationally invariant metric, which include the spherical and the hyperbolic case.