bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood Gender Nonconformity and Recalled Perceived Parental and Peer Acceptance Thereof, Internalized Homophobia, and Psychological Well-Being Outcomes in Heterosexual and Gay Men from Poland
Authors: Folkierska-Żukowska Monika , Rahman Qazi , Dragan Wojciech Ł. 
Published: June 2022

AbstractThe link between gender nonconformity and psychopathology may be due in part to negative childhood experiences resulting from other people’s reactions to gender nonconformity. The aim of this study was to test whether recalled perceived levels of parental and peer acceptance of childhood gender nonconforming behaviors and play mediate the relationship of childhood gender nonconformity with depression and social anxiety in adulthood. We also tested whether this relationship was moderated by sexual orientation and, among gay men, whether internalized homophobia was an additional mediator. All variables were measured in a large sample of male participants using self-report (n = 449 gay men, age: M = 27.8 years, SD = 6.69; andn = 296 heterosexual men, age: M = 27.4 years, SD = 6.57) in Poland. Gay men reported more childhood gender nonconformity than heterosexual men. The relationship between gender nonconformity and depressive symptoms as well as social anxiety symptoms was significant in both gay and heterosexual men. Among gay men, this relationship was partially mediated by peer but not parental acceptance of the measured aspects of gender nonconformity and internalized homophobia. Among heterosexual men, recalled perceived parental acceptance of gender nonconformity partially mediated the relationship between gender nonconformity and depressive and social anxiety symptoms. Our findings were partially in line with those found in Western European and North American samples. Although the two groups differed in their recalled perceived gender nonconformity, they did not differ in their depression or social anxiety scores. Nevertheless, childhood gender nonconformity may be an indirect risk associated with mental health symptoms, irrespective of sexual orientation. Its higher prevalence among nonheterosexual individuals makes it a particular risk for this group.
Conservation status of threatened land plants in China and priority sites for better conservation targets: distribution patterns and conservation gap analysis
Authors: Qin Fei , Xue Tiantian , Yang Xudong , Zhang Wendi , Wu Jianyong , Huang Yunfeng , Khan Gulzar , Yu Shengxiang 
Published: June 2022

AbstractThere are about 10% of the world’s land plants in China, of which 11% are threatened species. Here, we used China as a proxy to identify hotspots of threatened species, evaluate the effectiveness of current conservation networks and assess the correlations between distribution patterns of different groups. We built the most complete database of 3,881 species of threatened land plants in China (TLPCs) to date, based on 43,710 occurrence records at county level. A total of 467 counties identified as hotspot by species richness, complementarity, and weighted algorithms, mostly confined to the mountainous areas in southern China, which account for 15.58% of land area, however, hold 95.34% of the total TLPCs. The correlation analysis revealed weak to moderate relationship between the distribution patterns of three groups (bryophytes, ferns, and gymnosperms) and angiosperms of TLPCs. We found 86.34%, 84.05% and 95.77% of TLPCs protected by NNRs, PNRs and NRs [nature reserves, including both national NRs (NNRs) and provincial NRs (PNRs)], respectively. Besides, there were 41.11% and 18.84% of hotspots identified as conservation gaps of NNRs and NRs, respectively. In conclusion, the NNRs do not play a more dominant role in conserving TLPCs diversity in comparison to PNRs. We proposed that conservation planning need to be established in the periphery of Yunnan-Guizhou Plateau due to a large number of hotspots and conservation gaps located in this area. Since a large proportion of unprotected TLPCs are critically endangered and narrow-ranged species, it is urgent to set priorities for their conservation in the nearest future.
Optimization based on the minimum maximal k-partial-matching problem of finite states machines with input multiplexing
Authors: Garcia-Vargas Ignacio , Senhadji-Navarro Raouf 
Published: June 2022

AbstractFinite State Machines with Input Multiplexing (FSMIMs) were proposed in previous work as a technique for efficient mapping Finite State Machines (FSMs) into ROM memory. In this paper, we present new contributions to the optimization process involved in the implementation of FSMIMs in Field Programmable Gate Array (FPGA) devices. This process consists of two stages: (1) the simplification of the bank of input selectors of the FSMIM, and (2) the reduction of the depth of the ROM. This has a significant impact both on the number of used Look-Up Tables (LUTs) and on the number of the Embedded Memory Blocks (EMBs) required by the ROM. For the first stage, we present two approaches to optimize FSMIM implementations based on the Minimum Maximal k-Partial Matching (MMKPM) problem: one of them applies the greedy algorithm for the MMKPM problem, and the other based on a new multiobjetive variant of the MMKPM and its corresponding Integer Linear Programing formulation. We also propose a modification of the second stage, in which the characteristics of EMBs are taken into account to improve implementation results. The new optimization process significantly reduces the number of used FPGA resources with respect to the previous one. In addition, the proposed approaches achieve an adequate trade-off between the usage of EMBs and LUTs with respect to conventional FSM implementations based on ROM and to those based on LUT.
Exploring factors influencing pre-service and in-service teachers´ perception of digital competencies in the Chinese region of Anhui
Authors: Yang Li , Martínez-Abad Fernando , García-Holgado Alicia 
Published: June 2022

AbstractThe emergence of the Covid-19 pandemic has accelerated the wave of digital social transformation worldwide and pushed the “Accelerator Key” for the digital transformation of education in 2020. This transformation has also impacted in an all-around way in China. Taking Anhui province as a case study, this research explores socio-demographic factors influencing the digital competence level of pre- and in-service teachers of primary and secondary education in China. The quantitative methodological approach emphasizes the study subjects’ perception of their digital competencies in three factors: basic technology literacy, technical support learning, and technical support teaching. The study involved 250 pre-service teachers and 248 in-service teachers. The main findings are: (1) participants have good consciousness and attitudes towards using ICT in daily work, but their educational practice is weak; (2) in-service teachers have a digital competence level generally higher than pre-service teachers’, which might be their professional practice promote them to reflect on perceptions and attitudes regarding technological education; (3) for in-service teachers, there are significant differences between their digital competence level and age, years of teaching experience, educational background; (4) current ICT courses have no influencing on in-service teachers’ digital competence level, implying that current ICT training system may have problems. The study provides insights to improve pre-service teachers’ digital competence education in universities and develop well-designed in-service teachers’ ICT training courses.
Smart greenhouses as the path towards precision agriculture in the food-energy and water nexus: case study of Qatar
Authors: Karanisa Theodora , Achour Yasmine , Ouammi Ahmed , Sayadi Sami 
Published: June 2022

AbstractGreenhouse farming is essential in increasing domestic crop production in countries with limited resources and a harsh climate like Qatar. Smart greenhouse development is even more important to overcome these limitations and achieve high levels of food security. While the main aim of greenhouses is to offer an appropriate environment for high-yield production while protecting crops from adverse climate conditions, smart greenhouses provide precise regulation and control of the microclimate variables by utilizing the latest control techniques, advanced metering and communication infrastructures, and smart management systems thus providing the optimal environment for crop development. However, due to the development of information technology, greenhouses are undergoing a big transformation. In fact, the new generation of greenhouses has gone from simple constructions to sophisticated factories that drive agricultural production at the minimum possible cost. The main objective of this paper is to present a comprehensive understanding framework of the actual greenhouse development in Qatar, so as to be able to support the transition to sustainable precision agriculture. Qatar’s greenhouse market is a dynamic sector, and it is expected to mark double-digit growth by 2025. Thus, this study may offer effective supporting information to decision and policy makers, professionals, and end-users in introducing new technologies and taking advantage of monitoring techniques, artificial intelligence, and communication infrastructure in the agriculture sector by adopting smart greenhouses, consequently enhancing the Food-Energy-Water Nexus resilience and sustainable development. Furthermore, an analysis of the actual agriculture situation in Qatar is provided by examining its potential development regarding the existing drivers and barriers. Finally, the study presents the policy measures already implemented in Qatar and analyses the future development of the local greenhouse sector in terms of sustainability and resource-saving perspective and its penetration into Qatar’s economy.
Molecular Assessment of Staphylococcus Aureus Strains in STAT3 Hyper-IgE Syndrome Patients
Authors: Schwierzeck Vera , Effner Renate , Abel Felicitas , Reiger Matthias , Notheis Gundula , Held Jürgen , Simon Valeska , Dintner Sebastian , Hoffmann Reinhard , Hagl Beate , Huebner Johannes , Mellmann Alexander , Renner Ellen D. 
Published: June 2022

AbstractHyper-IgE syndromes (HIES) are a group of inborn errors of immunity (IEI) caused by monogenic defects such as in the gene STAT3 (STAT3-HIES). Patients suffering from HIES show an increased susceptibility to Staphylococcus aureus (S. aureus) including skin abscesses and pulmonary infections. To assess if the underlying immune defect of STAT3-HIES patients influences the resistance patterns, pathogenicity factors or strain types of S. aureus. We characterized eleven S. aureus strains isolated from STAT3-HIES patients (n = 4) by whole genome sequencing (WGS) to determine presence of resistance and virulence genes. Additionally, we used multi-locus sequence typing (MLST) and protein A (spa) typing to classify these isolates. Bacterial isolates collected from this cohort of STAT3-HIES patients were identified as common spa types in Germany. Only one of the isolates was classified as methicillin-resistant S. aureus (MRSA). For one STAT3 patient WGS illustrated that infection and colonization occurred with different S. aureus isolates rather than one particular clone. The identified S. aureus carriage profile on a molecular level suggests that S. aureus strain type in STAT3-HIES patients is determined by local epidemiology rather than the underlying immune defect highlighting the importance of microbiological assessment prior to antibiotic treatment.
Puesta en escena y proxémica en Dido y Eneas de Cristóbal de Morales Guerrero
Authors: Carmona Tierno Juan Manuel 
Published: June 2022

AbstractThis article offers a proxemic interpretation of Dido y Eneas, a Spanish Golden Age play written by Cristóbal de Morales Guerrero. It is a mythological work of which the plot is based on the protagonist’s psychological confrontation between desire, staying in Carthage with queen Dido, and duty, heading to Italy to begin the Roman lineage. Such forces are represented by two supernatural characters, goddess Venus and Creusa, Aeneas’ murdered wife transformed into a hellish spirit, respectively, who enter and exit the stage by spectacular means and employing special machinery. The use of these devices creates a strongly semanticised opposition according to which the top of the stage acquires a positive meaning and the bottom a negative one. In this context, it is perceived that Creusa tends to move upwards, whereas Venus does so downwards. These dynamics can be understood from both an axiological and dramatic view in the sense that the duty of sailing to Italy is the only reliable force since it is decreed by gods and, because of this, it will end up prevailing over desire, for Aeneas will indeed abandon Dido.
Older Patients with Acute Myeloid Leukemia Deserve Individualized Treatment
Authors: de Leeuw David C. , Ossenkoppele Gert J. , Janssen Jeroen J. W. M. 
Published: June 2022

Abstract

Purpose of Review
Treatment of elderly patients with acute myeloid leukemia is a known challenge for hematologists due to patient diversity, heterogeneous disease biology, and a rapidly evolving treatment landscape. Here, we highlight the importance of determining fitness, review the latest therapeutic developments, and discuss clinical scenarios to provide guidance on individualized treatment for older AML patients.

Recent Findings
Several factors, like age, performance status, and comorbidities, play a role in fitness and are associated with outcome. Comorbidity scoring systems and geriatric assessments are tools to help physicians select the most appropriate treatment for each patient. The addition of venetoclax, targeted therapy with IDH1/2 and FLT3 inhibitors, and enhanced formulas of existing drugs like CPX-351 and oral azacitidine have improved responses and outcomes.

Summary
New drugs and combination therapies have increased the therapeutic options for elderly AML patients but determination of fitness and disease biology is essential to select patient-tailored treatments.
Case reports: chemoradiotherapy for locally advanced neuroendocrine carcinoma of the gallbladder
Authors: Takeda Yuma , Kobayashi Noritoshi , Kessoku Takaomi , Okubo Naoki , Suzuki Akihiro , Tokuhisa Motohiko , Miwa Haruo , Udaka Naoko , Ichikawa Yasushi 
Published: June 2022

AbstractNeuroendocrine carcinoma (NEC) is a rare subtype of malignant gallbladder tumor. Although surgical resection is the only potentially curative therapy for gallbladder NEC, most cases are surgically unresectable because of advanced stage disease and/or biologically aggressive behavior. The standard palliative treatment for malignant gallbladder tumors is chemotherapy; however, the efficacy of chemoradiotherapy in the treatment of gallbladder tumors is controversial. Here, we report a case of gallbladder NEC that showed a durable response to chemoradiotherapy. A 68-year-old Japanese man presented with a huge gallbladder tumor with liver and duodenal invasion. Pathological findings revealed poorly differentiated NEC of the gallbladder. After seven cycles of chemotherapy comprising cisplatin and irinotecan, computed tomography (CT) revealed remarkable tumor shrinkage, but an enlarged portal lymph node. The patient was treated with 50.4 Gy in 28 fractions with two cycles of cisplatin and etoposide. After chemoradiotherapy, the enlarged lymph node also decreased in size. Maximum standardized uptake value of fluorodeoxyglucose-positron emission tomography/CT(FDG-PET/CT) changed from 8.2 to physiological accumulation. We defined this condition as a complete response on both enhanced CT and FDG-PET/CT; therefore, we did not perform systemic treatment and only observed his condition. This patient remained healthy with no recurrence at 3 years after chemoradiotherapy.
Access to Sexual Health Services and Support for People with Intellectual and Developmental Disabilities: an Australian Cross-sector Survey
Authors: Frawley Patsie , Wilson N.J. , David Jennifer , O’Shea Amie , Areskoug Josefsson K. 
Published: June 2022

Abstract
Introduction
People with intellectual and developmental disabilities under the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD) have the right to access sexual health services including information, education, and support. Little is known about the capacity of sexual health professionals to provide these services.

Methods
Using an observational research design, this study utilised a descriptive survey tool (PASH–Ext) that also encompassed a standardised measure, with a cross-sectional purposive sample of 52 Australian sexual health professionals. Data was collected in 2020.

Results
Just over half of the participants reported having received training in their preservice education to work with people with intellectual and developmental disabilities, of these 60% held the view that people with intellectual and developmental disabilities would not feel embarrassed receiving sexual health information and support.

Conclusion
The study found that training is both important to the professionals’ preparedness to work with people with intellectual and developmental disabilities, and that these professionals advocate for the continuation of this training in pre-service courses and additional training in post service education for sexual health workers.

Policy Implications
To progressively realise Article 25 of the UNCRPD signatory, countries need to ensure sexual health services are accessible to people with intellectual and developmental disabilities. This study recommends that sexual health policy addresses equity of access for people with intellectual and developmental disability by ensuring all staff are prepared and supported to provide these services.
Radical artifactualism
Authors: de Oliveira Guilherme Sanches 
Published: June 2022

AbstractA powerful idea put forward in the recent philosophy of science literature is that scientific models are best understood as instruments, tools or, more generally, artifacts. This idea has thus far been developed in combination with the more traditional representational approach: accordingly, current artifactualist accounts treat models asrepresentationaltools. But artifactualism and representationalism are independent views, and adopting one does not require acceptance of the other. This paper argues that a leaner version of artifactualism, free of representationalist assumptions, is both desirable and viable. Taking seriously the idea that models are artifacts can help us philosophically to make sense of how and why scientific modeling works even without reference to representation.
Monte Carlo method for fractional-order differentiation extended to higher orders
Authors: Leonenko Nikolai , Podlubny Igor 
Published: June 2022

AbstractIn this work the Monte Carlo method, introduced recently by the authors for orders of differentiation between zero and one, is further extended to differentiation of orders higher than one. Two approaches have been developed on this way. The first approach is based on interpreting the coefficients of the Grünwald–Letnikov fractional differences as so called signed probabilities, which in the case of orders higher than one can be negative or positive. We demonstrate how this situation can be processed and used for computations. The second approach uses the Monte Carlo method for orders between zero and one and the semi-group property of fractional-order differences. Both methods have been implemented in MATLAB and illustrated by several examples of fractional-order differentiation of several functions that typically appear in applications. Computational results of both methods were in mutual agreement and conform with the exact fractional-order derivatives of the functions used in the examples.
The Role of Regional Anesthesia in the Development of Chronic Pain: a Review of Literature
Authors: Kukreja Promil , Paul Lauren Mason , Sellers Alethia R. , Nagi Peter , Kalagara Hari 
Published: June 2022

Abstract

Purpose of Review
The acute management of pain using regional anesthesia techniques may prevent the development of persistent postsurgical pain (PPP), ultimately improving patient outcomes and enhancing overall quality of life in postsurgical patients. The purpose of this review is to describe the current literature regarding the role of regional anesthesia techniques in the perioperative setting to address and prevent PPP.

Recent Findings
Data was collected and analyzed using results from randomized controlled studies stratified into categories based on different surgical subspecialties. Conclusions were drawn from each surgical category regarding the role of regional anesthesia and/or local analgesia in acute and chronic pain management on the long-term results seen in the studies analyzed.

Summary
Preoperative consultations and optimized perioperative analgesia using regional anesthesia and local analgesia play a fundamental role preventing and treating postoperative pain after many types of surgery by managing pain in the acute setting to mitigate the future development of PPP. Additional studies in different surgical subspecialties are needed to confirm the role regional anesthesia plays in chronic postsurgical pain (CPSP) prevention.
Design and Analysis of Electromagnetic Quasi-zero Stiffness Vibration Isolator
Authors: MengTong Wang , Pan Su , ShuYong Liu , Kai Chai , BoXiang Wang , Jinfang Lu 
Published: June 2022

Abstract
Introduction
To improve the low frequency isolation capability of vibration isolation system, a kind of electromagnetic quasi-zero-stiffness (QZS) vibration isolator was designed.

Materials and methods
The negative stiffness electromagnetic spring paralleled with the linear positive stiffness spring to achieve the state of QZS. The nonlinear dynamic model of vibration isolator was established. Through the combination of theoretical formula and simulation analysis, the electromagnetic force expression was obtained. The amplitude-frequency responsecharacteristics and force transmissibility was solved by harmonic balance method, and the effects of system parameters on amplitude - frequency characteristics and transmissibility was analyzed.

Conclusion
The results show that the new isolator has better performance than the linear system, and the decreased damping ratio and excitation amplitude make the effects of vibration isolation of system superior.