bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concomitant septic arthritis of the hip joint and femoral head avascular necrosis in patients with recent covid-19 infection: A cautionary report
Authors: Ardakani Mohammad vahedian , parviz Sara , ghadimi Ehsan , zamani Zahra , salehi Mohammadreza , Ayati Mohammad , Mortazavi Javad SM 
Published: April 2022

Abstract
Purpose
At present, concomitant avascular necrosis (AVN) of femoral head and septic arthritis (SA) as a sequel of COVID-19 infection has yet not been documented. By large-scale use of life-saving corticosteroids (CS) in COVID-19 cases, our aim is to warn of the occurrence of hip joint infection in these patients.
Methods
We report a series of five cases in which patients developed septic arthritis concomitant with AVN after being treated for COVID-19 infection. The mean dose of prednisolone used in these cases was 1695.2 mg. The time period of onset of hip symptoms in our cases from the beginning of the COVID-19 infection was 56 days in the first case, 43 days in the second case, 30 days in the third case, 29 days in the forth case and 50 days in the last case, with an average time of 41.6 days. All patients underwent surgery depending on the extent of articular cartilage damage by direct anterior approach.
Results
Clinical and laboratory symptoms improved significantly in all patients. The mean visual analogue pain score of the patients decreased from 9.4 (9–10) before surgery to 2.8 (1–4) after one week of operation.
Conclusion
In any patient with the history of COVID-19 infection specially those who have been treated with corticosteroid as one of the medications prescribed during the disease, any joint symptom specially in the hips should draw our attention to the joint infection and with timely diagnosis and surgery, their hip joint can be saved.
A COVID-19 Data Set Design, Modeling,and Analysis on Selected Thirty Counties from Six States of the United States
Authors: Ji Raissa 
Published: April 2022

Abstract
In this four-month-long study (from April 1, 2020 to August 1, 2020), we have collected, modeled, and analyzed COVID-19 data from the top five most infected counties per top six most infected states in the United States (30 counties total). More specifically, we collected data on each state’s total COVID-19 cases, deaths, tests conducted, and their counties’ population, density, percentage of seniors, number of hospitals, total COVID-19 cases, and total COVID-19 related deaths. In this study, we have models illustrating the growth of COVID-19 cases and deaths per county, growth of COVID-19 cases and deaths per state (which is really the sum of our chosen five counties), and growth of COVID-19 tests conducted per state. In addition, our study also contains models illustrating the statistics of several variables that might have affected a county’s COVID-19 data, which has been mentioned above: population, density, percentage of seniors, and number of hospitals. An interesting finding we have noticed upon modeling the 30 counties’ density and total COVID-19 cases as an xy scatter plot is that there is a considerably strong relationship between the two variables. Los Angeles County (which was an extreme outlier), in particular, supports the idea that a county’s most populous city can greatly affect its entire county’s COVID-19 cases; if the largest city is extremely dense, it appears that the entire county has a greater total COVID-19 case count.
Identification of key molecules and significant signaling pathways in LINC00958 mediated endometrial cancer cells
Authors: Wang Xiu-ying , Chang Tingxiang , Wang Mengshan 
Published: April 2022

Abstract
Endometrial cancer is the most common gynecologic cancer in the United States. Since the cancers of the same stage and histology have very distinct molecular and genomic profiles, the therapy is quite limited. Current Long noncoding RNAs (lncRNAs) LINC00958 showed some benefit to this cancer, but the mechanism is unknown. In this study, we aim to identify the key molecules and signaling pathways by analyzing the RNA-seq data. The GSE198619 was created by the DNBSEQ-T7 (Homo sapiens). The KEGG and GO analyses indicated "Human T − cell leukemia virus 1 infection" and "Hippo signaling pathway" were the main affected biological processes. Moreover, we further figured out several interactive genes including CDK1, CDC42, JUN, FOS, CCNA2, KIF11, CCND1, KAT2B, MAD2L1, and NRAS. Our study may benefit the study of endometrial cancer treatment.
Finding Hidden Links among Variables in a Large-Scale 4G Mobile Traffic Network Dataset with Deep Learning
Authors: Diouf Ndolane , Ndong Massa , Diop Dialo , Talla Kharouna , Beye Aboubaker Chedikh , Gueye Ibrahima 
Published: April 2022

Abstract
Using a mobile dataset from Orange Senegal small cell 4G network, we study the effect of variables such as data traffic at the downlink level, data traffic at the uplink level, total data traffic, maximum number of active users, signaling protocol, uplink user rate, downlink user rate, physical resource block rate for downlink, block rate physical resources for uplink, load data logging, channel quality indicator, downlink radio delay average, over the perceived rate at the downlink. We are looking to find the variable that most affects the perceived flow. We do this by using machine learning to find the variable that closely explains the variation in perceived flow and helps predict flow with greater accuracy. We observe that correlation analysis is unable to find a hidden relationship between throughput and other variables. With models such as linear regression, decision tree, random forest, multi-layered perceptron and deep neural network, the channel quality indicator (CQI_Avg) turns out to be the variable that more closely explains the variation in perceived flow and more accurately contributes to the prediction compared to others variables.
Corrected: A Prognostic Necroptosis-Related lncRNA Signature to Predict the Immune Response and Drug Sensitivity of Bladder Cancer
Authors: Tian Chao , Chen Guiliu , Cao Zhengguo 
Published: April 2022

Abstract
Background: Patients with bladder cancer (BLCA), especially those with advanced stage cancer, have a short life span; thus, new drugs need to be developed urgently to improve the situation. Long noncoding RNAs (lncRNAs) are considered regulatory targets for cancer, including BLCA. Therefore, we constructed a promising signature of lncRNAs related to necroptosis and further predicted the immune response and sensitivity of drugs. Methods: We downloaded the transcriptome and clinical data for BLCA from the Cancer Genome Atlas（TCGA）. Necroptosis related to lncRNAs (nrlncRNAs) was subsequently identified by univariate Cox regression. We then constructed the signature by performing the least absolute shrinkage and selection operator(LASSO) and evaluated it by Kaplan–Meier analysis, multivariate Cox regression, time-dependent receiver operating characteristics (ROC), nomogram, calibration curves, gene set enrichment analyses(GSEA), immune checkpoint, tumor microenvironment(TME), N6-methyladenosine (m6A) modification genes, and the half-maximal inhibitory concentration (IC50) analysis in the risk groups. Results: An 11-nrlncRNAs (AC008750.1, AL133297.1, AC005479.1, AP003559.1, UBE2Q1-AS1, MIR100HG, LINC02709, AC005387.1, LINC00649, AC021321.1, ETV7-AS1) prognostic signature was constructed. Immune checkpoint analysis revealed that the expression of most of the immune genes in the high-risk group was higher than those in the low-risk group. The signature predicted different IC50 values to have statistical significance in high-and low-risk groups for multiple drugs. Conclusion: Our constructed signature may contribute to the prognosis of patients with BLCA as well as serve as clinical predictors of chemotherapy and immunotherapy.
Benefits Maximization of Distribution Company with Optimal Placement of Distributed Generation and Shunt Capacitor
Authors: Siddique Abubakar , Aslam Waseem , Aslam M.Nadeem , Aslam M.Kaleem 
Published: April 2022

Abstract
In the present scenario of rising environmental concern and enormous load growth, the distribution system owners must undertake the decision of distribution system planning to keep the secure operation of the system and to survive in the competitive energy market. The enormous load growth can be tackled by installing new conventional generation units and increasing the feeders’ capacity. But this will cause environmental pollution and problem for the system owner from a financial standpoint. Under such circumstances, this study proposed a planning approach for optimal allocation of distribution generation (DIG) and shunt capacitor (SC) intending to maximize the technical and economic benefits of the system. Renewable energy sources based on DIG, such as solar and wind energy systems are taken into account. The time-varying characteristics of active and reactive power demand are also considered. A multi-stage planning model is considered where the planning horizon of 10 years is divided into two stages. A soft computing technique, namely Particle Swarm Optimization (PSO) technique, is applied to solve the problem. Moreover, the 33-bus distribution network is taken as the test system and different planning scenarios are considered for an in-depth planning and analysis purpose.
Does Provider Matter? A Systematic Review of Evidence Supporting Performance of SI Joint Fusion by Surgeons Rather Than Non-Surgeons
Authors: Brown Nolan J. , Nguyen Andrew , Vu Victor , Beyer Ryan S. , Hatter Matthew J. 
Published: April 2022

Abstract
Introduction
As patient demand for minimally invasive SIJF has increased, non-surgeons (including pain management physicians) have begun to perform a growing number of minimally invasive posterior SIJF procedures, even though these have traditionally been reserved for spine surgeons, whose extensive training renders them experts in spinal instrumentation and biomechanics.
Objectives
We compare and contrast levels of evidence and data available on minimally invasive SIJF devices in the literature published by both spine surgeons and non-surgeons. In doing so, we hope to provide insight on the role of non-surgeons in managing spinal disease in light of the Position Statement set forth by the AANS and CNS in August 2021.
Methods
A PubMed search and initial screen yielded 11 studies that were subjected to full text analysis. Using the list of SIJF devices obtained from these studies, additional searches were conducted using the National Institute of Health (NIH) Clinical Trials website and FDA 510(k), among others, yielding 6 unique devices that can currently be used by non-surgeons in the posterior SIJF approach.
Results
Spine surgeons generally perform lateral or posterolateral MIS SIJF. There are 11 unique FDA-approved devices and a total of 33 SIJF devices overall. 10 of these devices have been described in numerous reports within the peer-reviewed medical literature. For example, Titanium Triangular Implants (lateral) are described in 11 retrospective studies (level 4 evidence), 2 level 2 prospective studies, and 2 level 1 prospective studies. By contrast, non-surgeons have only investigated the use of posterior allograft devices in 2 studies. One of these studies (PainTEQ) is featured on ClinicalTrials.gov and will not be complete until March 2022. The other is a systematic review citing 6 studies on posterior SIJF performed by non-surgeons. However, these are non-peer reviewed conference abstracts – 2 of which are featured on the CornerLoc device website – and therefore cannot be assigned meaningful levels of evidence.
Conclusion
Instrumentation of the spine requires extensive surgical training such as that completed by spine surgeons. There is an increasing body of evidence in the literature supporting the performance of MIS SIJF for SI disease by spine surgeons. However, there is no evidence supporting the performance of this procedure by non-surgeons.
Transforming Communication in Health Care via Information Technology: Implementation of a free telephone directory app
Authors: Hania A , Barkat R 
Published: April 2022

Abstract
Background:Timely communication is key to patient safety and management in health care. Communication failure and delays in the transfer of information between healthcare workers can result in avoidable errors. We measured the effect of the implementation of a free telephone directory app for hospital staff to connect efficiently within the hospital.Methods:We implemented a free telephone directory app for smartphones which is available to all hospital staff that provides immediate access to all the internal phone lines and bleeps without calling switch. An audit of telephone calls made to switch before and after the implementation of the app was then performed.Results:Number of total calls to switch board in a 24hour period reduced by 10.9% (2,248 to 2,002 calls) following implementation of the app. The proportion of calls to switch which were from an internal line with staff requesting the number of an internal line or bleep was also reduced from 29.9% (n=672) to 24.6% (n=492), p-value <0.001.Conclusion:The use of a hospital phone directory app with mobile technology is a cost-effective measure that can benefit the hospital by improving efficiency in hospital switchboards, enhance communication and productivity for healthcare workers which can help improve patient care.
Improving the Face Validity of Self-Report Scales through Cognitive Interviews Based on Tourangeau Question and Answer Framework: A Practical Work on the Nursing Talent Identification Scale
Authors: Zamanzadeh Vahid , Ghahramanian Akram , Valizadeh Leila , bagheriyeh farzaneh 
Published: April 2022

Abstract
Objective: The Nursing Talent Identification self-report Scale is a recently developed to assess the fit of nursing applicants’ characteristics for the profession. In such scales, respondents may perceive items in a variety of ways.The present study aimed to determine how respondents understand and answer to items through cognitive interviews to assess the user-friendliness of the scale and increase its face validity.Results: Through conducting 20 interviews with the participants, problems related to item comprehension, information retrieval, judgment and reporting appropriate answers were identified. Based on the results, out of 95 items, 20 items were modified. The ‘instructions’ section of the scale was also revised by making the necessary explanations and providing an example.
Identification of hub genes and their clinical value for predicting the development of prostate cancer from benign prostate hyperplasia by bioinformatic analysis
Authors: Chen Xi , Ma Junjie , Xu Chengdang , Wang Licheng , Yao Yicong , Wang Xinan , Zi Tong , Bian Cuidong , Wu Denglong , Wu Gang 
Published: April 2022

Abstract
Prostate cancer (PCa) and benign prostate hyperplasia (BPH) are commonly encountered diseases in males. Studies showed that genetic factors are responsible for the occurrences of both diseases. However, the genetic association between them is still unclear. Gene Expression Omnibus (GEO) database can help determine the differentially expressed genes (DEGs) between BPH and PCa. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were utilized to find pathways DEGs enriched. The STRING database can provide a protein–protein interaction (PPI) network, and find hub genes in PPI network. GEPIA can be used to analyze expression and survival data for hub genes. R software was used to progress regression analysis. Finally, the results were tested in other databases, clinical samples and PCa cells. Fifteen up-regulated and forty-five down-regulated genes were found from GEO database. Seven hub genes were found in PPI network. The hub gene expression was tested on The Cancer Genome Atlas (TCGA) data. Except CXCR4, all hub genes expressed differently between tumor and normal samples. Exclude CXCR4, other hub genes have diagnostic value in predicting PCa and their mutations can cause PCa. The expression of CSRP1, MYL9 and SNAI2 changed in different tumor stage. CSRP1 and MYH11 could affect disease-free survival (DFS). Same results reflected in different databases. The expression and function of MYC, MYL9, and SNAI2, were validated in clinical samples and PCa cells. In conclusion, seven hub genes among sixty DEGs can be achievable targets for predicting which BPH patients may later develop PCa.
Influence of reaction time, temperature and heavy metal on characteristics of cellulose- and wood-derived hydrochars from hydrothermal carbonization
Authors: Zhao Xin , Huang Jin , Li Zhaonan , Chen Yao , Müller Michael 
Published: April 2022

Abstract
Hydrothermal carbonization (HTC) is a promising technique to convert biomass into valuable solid fuels. In this work, cellulose and wood-derived hydrochars were synthesized under hydrothermal carbonization conditions with different temperatures (200–250 ℃), reaction times (6 h or 12 h) and to determine their influence on hydrochars. Heavy metal element zinc is chosen to introduce into samples to simulate the heavy metal accumulate in biomass. The physical, chemical, and combustion properties of the hydrochars revealed that the majority of cellulose and wood conversion occurs at first 6 h, and faster conversion occurs at higher temperatures. The content of fixed carbon in the cellulose-derived hydrochar is higher than in wood-derived hydrochar. Moreover, cellulose is easier to be carbonized during HTC reaction than wood. O/C and H/C ratios of all hydrochars were similar to those of lignite and decreased with increasing reaction temperature. The composition of solids recovered after 12 h is similar at all temperatures, consisting primarily of sp2 carbons (furanic and aromatic groups) and alkyl groups. When a large amount of metal is introduced, part of the metal is combined with the energetic group, while the rest condense on the surface of the sample as zinc ions.
Hemolytic Iron Regulation in Traumatic Brain Injury and Alcohol Use
Authors: Agas Agnieszka , Ravula Arun Reddy , Ma Xiaotang , Cheng Yiming , Belfield Kevin D. , Haorah James 
Published: April 2022

Abstract
Hemorrhage is often a major component of traumatic brain injury (TBI). Red blood cells (RBCs), accumulated at the hemorrhagic site, undergo hemolysis upon energy depletion. Hemolysis of RBCs is expected to release free iron into the central nervous system (CNS) which must be managed to prevent iron neurotoxicity. Here, we examine the hypothesis that chronic alcohol consumption, as a secondary stressor, may increase iron toxicity in a rat model of TBI by altering the iron management pathways. We found large accumulations of free iron at the site of hemorrhage with evidence of hemolytic activity. Our observations demonstrate that alcohol use can alter the three distinct iron management pathways: transferrin/hemosiderin binding, lipocalin 2/heme oxygenase 1/ferritin system, and possible microglial phagocytosis. Presence of alcohol prolonged the expression of lipocalin 2 as well as increased and sustained levels of ferritin, while the combined effects of alcohol and TBI elevated the levels of heme oxygenase 1 faster than TBI alone. The hippocampus, neocortex, ventricles, and around vessels near the site of impact appeared to be the prominent brain regions of induction. In addition, we provide evidence that microglia my also play a role in iron management through RBC phagocytosis.
Improving of deinking technology of printing recovered paper
Authors: Мидукова М.А. , Смирнова Е.Г. , Смолин А.С. 
Published: April 2022

Исследована возможность повысить эффективность очистки макулатуры марки МС-7Б от тонера, нанесённого на лазерном принтере путём сухого двухстадийного диспергирования перед флотацией. Использовалась макулатура с разным уровнем запечатанности с одной стороны бумаги: 2,5%, 3,9, 8,2, 60%. Степень запечатанности офисной макулатуры определяли с помощью программы «lpSquare v5.0 for Windows» как отношение площади запечатанной области к общей площади листа (в %). Уровень очистки макулатуры от вкраплений тонера определяли с помощью графической программы, которая позволяла установить площадь области чёрного цвета. Установлено, что разработанная технология подготовки макулатурной массы, включающая двухстадийное сухое диспергирование и последующую флотацию, эффективно удаляет вкрапления тонера в образцах бумаги. Вкрапления тонера в образцах бумаги, полученной из макулатуры облагороженной флотацией с предварительным двухстадийным сухим диспергированием, практически отсутствуют, в отличие от образцов бумаги из макулатуры, облагороженной стандартной флотацией. Оценка механических свойств образцов бумаги осуществлялась по изменению показателей – сопротивления продавливанию и сопротивления разрыву. Показано, что подготовка макулатурной массы методом флотации с предварительным сухим дисперированием способствует небольшому повышению механических показателей образцов бумаги. Механические показатели образцов бумаги практически не зависят от уровня запечатанности макулатуры.
The possibility of improving the efficiency of deinking «МС-7Б» grade recovered paper from toner applied on a laser printer by dry two-stage dispersion before flotation was investigated. Recovered paper was used with a different level of toner print on one side of the paper: 2.5%; 3,9%; 8,2%; 60%. The degree of toner prints of office recovered paper was determined by the program «lpSquare v5.0 for Windows» as the ratio of the area of the printed area to the total area of the sheet in %. The level of cleaning recovered paper from toner embossments was determined using a graphic program that made it possible to establish the area of the black area. It has been found that the developed recovered paper stock preparation technology involving two-stage dry dispersion and subsequent flotation effectively removes toner print area in paper samples. Toner print area in samples of paper obtained from floated recovered paper with preliminary two-stage dry dispersion are practically absent, unlike samples of paper from recovered paper ennobled with standard flotation. Assessment of mechanical properties of paper samples was carried out by changing the values of bursting and tinsel strength. It is shown that preparation of recovered paper stock by method of flotation with preliminary dry dispersion contributes to small increase of mechanical indices of paper samples. The mechanical properties of paper samples practically does not depend on the level of toner print area of recovered paper.
Treatment on thiodicarb in pesticide wastewater with walnut shells-derived carbon and its improved modification: adsorption behavior
Authors: Bai Haifeng , Wang Bin , Talifu Dilinuer , Abulizi Abulikemu , Maihemuti Mailikezhati 
Published: April 2022

AbstractThe health problems caused by water pollution cannot be ignored, and the contribution of pesticides to water pollution has also become increasingly unignorable. The modified semi-coke as an adsorbent for reducing pesticide pollution to water was obtained from activated semi-coke which was modified by nitric acid (HNO3). The semi-coke was obtained by carbonization using 60 mesh walnut shell powder. After acid–base deashing, the semi-coke is dipped into zinc chloride (ZnCl2) solution to obtain activated semi-coke. Through BET analysis, the specific surface areas of semi-coke, activated semi-coke and modified semi-coke were 26.8 m2/g, 243.9 m2/g, and 339.6 m2/g respectively. An extremely high adsorption capacity of the adsorbents which is used to treat wastewater was achieved. The optimum adsorption conditions for modified semi-coke on thiodicarb solution were 30 mg/L of thiodicarb solution, adsorbent dosage of 0.01 g, adsorption temperature of 25 °C and adsorption time of 90 min. The optimum adsorption amount of 29.54 mg/gsor was achieved (sor is the abbreviation for sorbent). Moreover, through kinetics study, the result manifests that the modified semi-coke adsorption process is more fitted to the second-order kinetic model. This study provided a research implication theoretically for the treatment of pesticides in water.