bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multidirectional motion coupling based extreme motion control of distributed drive autonomous vehicle
Authors: Wang Kai , Yang Mingliang , Li Yang , Liu Zibin , Wang Haiying , Ding Weiping 
Published: August 2022

AbstractTo improve the multidirectional motion control accuracy and driving stability of Distributed Drive Autonomous Vehicles (DDAVs) under extreme conditions, the extreme speed estimation method based on dynamic boundary and the multidirectional motion coupling control law design method based on multi degrees of freedom vehicle dynamic model are proposed. The extreme speed estimation method identifies the stable state of DDAVs by the dynamic boundary composed of yaw rate, sideslip angle and roll angle, and then estimates the extreme speed of the vehicle. The design method of multidirectional motion coupling control law adopts eight-degrees-of-freedom (8-DOF) vehicle dynamic model to design path tracking control law, speed tracking control law, yaw stability control law, and active suspension control law at the same time, so as to realize multidirectional motion coupling control. Based on the above method, the Multidirectional Motion Coupling Control System (MMCCS) of DDAVs is designed. The effectiveness of the proposed method is verified by double-line-shifting and serpentine driving simulations under different road adhesion conditions. The superiority of the method is proved by comparing the existing integrated control method.
The interplay between cognition, depression, anxiety, and sleep in primary Sjogren’s syndrome patients
Authors: Goulabchand Radjiv , Castille Elodie , Navucet Sophie , Etchecopar-Etchart Damien , Matos Aurélie , Maria Alexandre , Gutierrez Laure Anne , Le Quellec Alain , de Champfleur Nicolas Menjot , Gabelle Audrey , Guilpain Philippe 
Published: August 2022

AbstractPrimary Sjögren’s syndrome (pSS) is an autoimmune disease with frequent neurological involvement. Memory complaints are common, but their precise patterns remain unclear. We wanted to characterize patterns of neurocognitive profiles in pSS patients with cognitive complaints. Only pSS patients with memory complaints were included, prospectively. Cognitive profiles were compiled through a comprehensive cognitive evaluation by neuropsychologists. Evaluations of anxiety, depression, fatigue, sleep disorders and quality of life were performed for testing their interactions with cognitive profiles. All 32 pSS patients showed at least borderline cognitive impairment, and 17 (53%) exhibited a pathological cognitive profile: a hippocampal profile (37%), a dysexecutive profile (22%), and an instrumental profile (16%) (possible overlap). Regarding the secondary objectives: 37% of patients were depressed, and 48% exhibited a mild-to-severe anxiety trait. Sleep disorders were frequent (excessive daytime sleepiness (55%), high risk for sleep apnea (45%), and insomnia (77%)). Cognitive impairments could not be explained alone by anxiety, depression or sleep disorders. Fatigue level was strongly associated with sleep disorders. Our study highlights that cognitive complaints in pSS patients are supported by measurable cognitive impairments, apart from frequently associated disorders such as depression, anxiety or sleep troubles. Sleep disorders should be screened.
Green and sustainable chitosan–gum Arabic nanocomposites as efficient anticorrosive coatings for mild steel in saline media
Authors: Al Kiey Sherief A. , Hasanin Mohamed S. , Heakal Fakiha El-Taib 
Published: August 2022

AbstractThe application of green and sustainable anticorrosive coatings is becoming of upsurge interest for the protection of metallic materials in aggressive environments. Herein, a stable crystalline chitosan/gum Arabic composite (CGAC) nanopowder was successfully synthesized and characterized by various methods. The CGAC nanopowder with different doses (25, 50, 100, and 200 ppm) was used to coat mild steel samples and examined its anticorrosion ability in 3.5 wt.% NaCl solution using gravimetric, electrochemical measurements, and surface characterization techniques. All methods yielded consistent results revealing that nanocomposite coatings can impart good anticorrosive properties to the steel substrate. The obtained protection efficiency was enhanced with increasing CGAC dose in the applied surface layer achieving 96.6% for the 200 ppm-coating. SEM and AFM surface morphologies of uncoated and coated samples after the inundation in the saline solution showed that CGAC coating can block the active corrosive sites on the steel surface, and prevent the aggressive Cl-ions from attacking the metallic substrate. The water droplet contact angle gave further support as it increased from 50.7° for the pristine uncoated surface to 101.2° for the coated one. The current research demonstrates a promising natural and reliable nanocomposite coating for protecting mild steel structures in the marine environment.
On-the-fly investigation of XUV excited large molecular ions using a high harmonic generation light source
Authors: Hervé Marius , Boyer Alexie , Brédy Richard , Allouche Abdul-Rahman , Compagnon Isabelle , Lépine Franck 
Published: August 2022

AbstractWe present experiments where extreme ultraviolet femtosecond light pulses are used to photoexcite large molecular ions at high internal energy. This is done by combining an electrospray ionization source and a mass spectrometer with a pulsed light source based on high harmonic generation. This allows one to study the interaction between high energy photons and mass selected ions in conditions that are accessible on large-scale facilities. We show that even without an ion trapping device, systems as large as a protein can be studied. We observe light induced dissociative ionization and proton migration in model systems such as reserpine, insulin and cytochrome c. These results offer new perspectives to perform time-resolved experiments with ultrashort pulses at the heart of the emerging field of attosecond chemistry.
Mesopic conditions optimise the detection of visual function loss in drivers with simulated media opacity
Authors: Asare Frederick A. , Anderson Roger S. , Mulholland Pádraig J. , Little Julie-Anne 
Published: August 2022

AbstractDrivers have different visual demands across varying contrast and luminance conditions. However, vision assessments for driving are typically conducted under photopic conditions. This study investigated the sensitivity of photopic and mesopic conditions to detect contrast sensitivity (CS) loss in drivers with simulated media opacities. CS was measured in forty-seven healthy drivers aged 18–50 years (mean ± SD: 25.5 ± 6.5) under photopic and mesopic-adapted luminance levels with the Pelli-Robson chart and the Mesotest II (without glare). Media opacities were simulated using white-opacity containing Lee Fog filters (1–5) and CS measured in a randomised order. A significant (p < 0.001) reduction in photopic CS (logCS) was measured with the Pelli-Robson chart only when media opacity was simulated with Fog filter 5 (1.53 ± 0.15, 2.8 triplets reduction) compared to baseline (1.95 ± 0.03). Mean mesopic CS demonstrated a significant (all p < 0.001) reduction from baseline (1.67 ± 0.14) for Fog filters 3 (1.4 triplets, 1.45 ± 0.16), 4 (2.4 triplets, 1.31 ± 0.14) and 5 (4.3 triplets, 1.02 ± 0.15). For Mesotest II, only Fog filter 5 produced a significant reduction (0.10 ± 0.09; p < 0.001) in mean mesopic CS from baseline (0.30 ± 0.01). Mesopic CS is more vulnerable to different levels of simulated media opacity, hence should be considered clinically when assessing visual function in older drivers at risk of media opacity.
Roll to roll in situ preparation of recyclable, washable, antibacterial Ag loaded nonwoven fabric
Authors: Xu Yanfang , Tian Lulu , Li Junfang , Lv Xiaohui , Li Fei , Sun Li , Niu Liyong , Li Xiaohong , Zhang Zhijun 
Published: August 2022

AbstractFunctional fabrics with antibacterial performance are more welcome nowadays. However, the fabrication of functional fabrics with durable, steady performance via a cost-effective way remains a challenge. Polypropylene (denoted as PP) nonwoven fabric was modified by polyvinyl alcohol (denoted as PVA), followed by the in-situ deposition of silver nanoparticles (denoted as Ag NPs) to afford PVA-modified and Ag NPs-loaded PP (denoted as Ag/PVA/PP) fabric. The encapsulation of PP fiber by PVA coating contributes to greatly enhancing the adhesion of the loaded Ag NPs to the PP fiber, and the Ag/PVA/PP nonwoven fabrics exhibit significantly improved mechanical properties as well as excellent antibacterial activity against Escherichia coli (coded as E. coli). Typically, the Ag/PVA/PP nonwoven fabric obtained at a silver ammonia concentration of 30 mM has the best mechanical properties and the antibacterial rate reaches 99.99% against E. coli. The fabric retains excellent antibacterial activity even after washing for 40 cycles, showing prospects in reuse. Moreover, the Ag/PVA/PP nonwoven fabric could find promising application in industry, thanks to its desired air-permeability and moisture-permeability. In addition, we developed a roll-to-roll production process and conducted preliminary exploration to verify the feasibility of this method.
Sputnik-V reactogenicity and immunogenicity in the blood and mucosa: a prospective cohort study
Authors: Yegorov Sergey , Kadyrova Irina , Negmetzhanov Baurzhan , Kolesnikova Yevgeniya , Kolesnichenko Svetlana , Korshukov Ilya , Baiken Yeldar , Matkarimov Bakhyt , Miller Matthew S. , Hortelano Gonzalo H. , Babenko Dmitriy 
Published: August 2022

AbstractSputnik-V (Gam-COVID-Vac) is a heterologous, recombinant adenoviral (rAdv) vector-based, COVID-19 vaccine now used in > 70 countries. Yet there is a shortage of data on this vaccine's performance in diverse populations. Here, we performed a prospective cohort study to assess the reactogenicity and immunologic outcomes of Sputnik-V vaccination in Kazakhstan. COVID-19-free participants (n = 82 at baseline) were followed at day 21 after Sputnik-V dose 1 (rAd5) and dose 2 (rAd26). Self-reported local and systemic adverse events were captured using questionnaires. Blood and nasopharyngeal swabs were collected to perform SARS-CoV-2 diagnostic and immunologic assays. We observed that most of the reported adverse events were mild-to-moderate injection site or systemic reactions, no severe or potentially life-threatening conditions were reported, and dose 1 appeared to be more reactogenic than dose 2. The seroconversion rate was 97% post-dose 1, remaining the same post-dose 2. The proportion of participants with detectable virus neutralization was 83% post-dose 1, increasing to 98% post-dose 2, with the largest relative increase observed in participants without prior COVID-19 exposure. Dose 1 boosted nasal S-IgG and S-IgA, while the boosting effect of dose 2 on mucosal S-IgG, but not S-IgA, was only observed in subjects without prior COVID-19. Systemically, vaccination reduced serum levels of growth regulated oncogene (GRO), which correlated with an elevation in blood platelet count. Overall, Sputnik-V dose 1 elicited both blood and mucosal SARS-CoV-2 immunity, while the immune boosting effect of dose 2 was minimal. Thus, adjustments to the current vaccine dosing regimen are necessary to optimize immunization efficacy and cost-effectiveness. While Sputnik-V reactogenicity is similar to that of other COVID-19 vaccines, the induced alterations to the GRO/platelet axis warrant investigation of the vaccine’s effects on systemic immunology.
Prediction of phonon-mediated superconductivity in new Ti-based M$$_2$$AX phases
Authors: Karaca E. , Byrne P. J. P. , Hasnip P. J. , Probert M. I. J. 
Published: August 2022

AbstractA high-throughput computational method is used to predict 39 new superconductors in the Ti-based M$$_2$$

2

AX phases, and the best candidates are then studied in more detail using density functional theory electron–phonon coupling calculations. The detailed calculations agree with the simple predictions, and Ti$$_2$$

2

AlX (X: B, C and N) materials are predicted to have higher values of $$T_c$$

T
c

than any currently known hexagonal M$$_2$$

2

AX phases. The electronic states at the Fermi level are dominated by the Ti 3d states. The choice of X (X: B, C and N) has a significant impact on the electronic density of states but not on the phonon characteristics. The electron–phonon coupling parameter for Ti$$_2$$

2

AlX (X: B, C and N) was determined to be 0.685, 0.743 and 0.775 with a predicted $$T_c$$

T
c

of 7.8 K, 10.8 K and 13.0 K, respectively.
Novel nanosensor of cobalt(II) and copper(II) constructed from graphene quantum dots modified with Eriochrome Black T
Authors: Vahab Leila , Keshipour Sajjad 
Published: August 2022

AbstractDetection of heavy transition metals is of importance protecting humans and the environment from their toxicity. Amongst them, copper(II) and cobalt(II) need more attention due to their wide applications in industry, in which exposures with excess amounts of them cause heathy concerns. Hence, fast and efficient distinguishing copper(II) and cobalt(II) could be worthy. While electrochemical approaches could determine these cations, expensive instrumentation and time-consuming analysis are significant drawbacks, leading to concentrations on spectroscopic and colorimetric pathways. Herein, graphene quantum dot was modified with Eriochrome Black T (EBT) to generate a novel sensor with the ability of sensing mentioned cations. This new nanocompound demonstrated new optical properties when complexed with cobalt(II) in natural pH, and copper(II) in acidic media. Both cations successfully were detected by the new nanosensor through revealing distinct spectroscopic signals. Moreover, cobalt(II) was distinguished by this sensor colorimetrical, appearing green solution. Linear ranges of cobalt(II) and copper(II) were obtained as 0.02–0.08 M and 0.015–0.2 M, with the limit of detections 0.014 and 0.018 M, respectively.
Weak Hadley cell intensity changes due to compensating effects of tropical and extratropical radiative forcing
Authors: Kim Doyeon , Kim Hanjun , Kang Sarah M. , Stuecker Malte F. , Merlis Timothy M. 
Published: August 2022

AbstractThe Hadley cell response to globally increasing CO2concentrations is spatially complex, with an intensified rising branch and weakened descending branch. To better understand these changes, we examine the sensitivity of the Hadley cell to idealized radiative forcing in different latitude bands. The Hadley cell response is, to first order, governed by the latitudinal structure of the forcing. The strengthening of the upward branch is attributed to tropical forcing, whereas the weakening of the descending branch is attributed to extratropical forcing. These direct radiatively-forced Hadley cell responses are amplified by changes in atmospheric eddy heat transport while being partially offset by changes in gross moist stability and ocean heat uptake. The radiative feedbacks further modulate the Hadley cell response by altering the meridional atmospheric energy gradient. The Hadley cell projections under global warming are thus a result of opposing – and thus compensating – effects from tropical and extratropical radiative forcings.
Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group
Authors: Nguyen Minh-Tram T. , Shih Yu-Chien , Lin Meng-Hsuan , Roffler Steve R. , Hsiao Chiao-Yu , Cheng Tian-Lu , Lin Wen-Wei , Lin En-Chi , Jong Yuh-Jyh , Chang Chin-Yuan , Su Yu-Cheng 
Published: August 2022

AbstractCovalent attachment of methoxy poly(ethylene) glycol (mPEG) to therapeutic molecules is widely employed to improve their systemic circulation time and therapeutic efficacy. mPEG, however, can induce anti-PEG antibodies that negatively impact drug therapeutic effects. However, the underlying mechanism for specific binding of antibodies to mPEG remains unclear. Here, we determined the first co-crystal structure of the humanized 15-2b anti-mPEG antibody in complex with mPEG, which possesses a deep pocket in the antigen-binding site to accommodate the mPEG polymer. Structural and mutational analyses revealed that mPEG binds to h15-2b via Van der Waals and hydrogen bond interactions, whereas the methoxy group of mPEG is stabilized in a hydrophobic environment between the VH:VL interface. Replacement of the heavy chain hydrophobic V37 residue with a neutral polar serine or threonine residue offers additional hydrogen bond interactions with methoxyl and hydroxyl groups, resulting in cross-reactivity to mPEG and OH-PEG. Our findings provide insights into understanding mPEG-binding specificity and antigenicity of anti-mPEG antibodies.
Classical analog of qubit logic based on a magnon Bose–Einstein condensate
Authors: Mohseni Morteza , Vasyuchka Vitaliy I. , L’vov Victor S. , Serga Alexander A. , Hillebrands Burkard 
Published: August 2022

AbstractAdvances in quantum computing and telecommunications stimulate the search for classical systems allowing partial implementation of a similar functionality under less stringent environmental conditions. Here, we present a classical version of several quantum bit (qubit) functionalities using a two-component magnon Bose–Einstein condensate (BEC) formed at opposite wavevectors in a room-temperature yttrium-iron-garnet ferrimagnetic film. Employing micromagnetic numerical simulations, we show the use of wavelength-selective parametric pumping to controllably initialize and manipulate the two-component BEC. Next, by modeling the interaction of this BEC with a pulse- and radio-frequency-driven dynamic magnonic crystal we translate the concept of Rabi-oscillations into the wavevector domain and demonstrate how to manipulate the magnon-BEC system regarding the polar and azimuthal angles in the Bloch sphere representation. We hope that our study provides a significant stimulus on the boundary between qubit functionality and classical systems of interacting BECs, which use a subset of qubit-based algorithms.
Orthogonal antiferromagnetism to canted ferromagnetism in CaCo3Ti4O12 quadruple perovskite driven by underlying kagome lattices
Authors: Amano Patino Midori , Denis Romero Fabio , Koo Hyun-Joo , Avdeev Maxim , Injac Sean D. A. , Goto Masato , Whangbo Myung-Hwan , Shimakawa Yuichi 
Published: August 2022

AbstractAA′3B4O12 quadruple perovskites, with magnetic A′ and non-magnetic B cations, are characterized by a wide range of complex magnetic structures. These are due to a variety of competing spin-exchange interactions up to the fourth nearest neighbours. Here, we synthesize and characterize the magnetic behaviour of the CaCo3Ti4O12 quadruple perovskite. We find that in the absence of an external magnetic field, the system undergoes antiferromagnetic ordering at 9.3 K. This magnetic structure consists of three interpenetrating mutually orthogonal magnetic sublattices. Under an applied magnetic field, this antiferromagnetic structure evolves into a canted ferromagnetic structure. In explaining these magnetic structures, as well as the seemingly unrelated magnetic structures found in other quadruple perovskites, we suggest a crucial role played by the underlying kagome lattices in these systems. All observed magnetic structures of these materials represent indeed one of the three possible ways to reduce spin frustration in the A′ site kagome layers. More specifically, our survey of the magnetic structures observed for quadruple perovskites AA′3B4O12 reveals the following three ways to reduce spin frustration, namely to make each layer ferromagnetic, to adopt a compromise 120° spin arrangement in each layer, or to have a magnetic structure with a vanishing sum of all second nearest-neighbour spin exchanges.
Anticoagulant Effects of Dabigatran on Coagulation Laboratory Parameters in Pediatric Patients: Combined Data from Five Pediatric Clinical Trials
Authors: Mitchell Lesley G. , Röshammar Daniel , Huang Fenglei , Albisetti Manuela , Brandão Leonardo R. , Bomgaars Lisa , Chalmers Elizabeth , Halton Jacqueline , Luciani Matteo , Joseph David , Tartakovsky Igor , Gropper Savion , Brueckmann Martina 
Published: August 2022

Background Dabigatran etexilate, a direct oral thrombin inhibitor, is approved to treat venous thromboembolism (VTE) in both adults and children.
Objectives This population analysis characterized relationships between dabigatran total plasma concentrations and coagulation laboratory parameters (activated partial thromboplastin time [aPTT]; diluted thrombin time [dTT]; ecarin clotting time [ECT]).
Methods Data from three phase 2a and one single-arm and one randomized, comparative phase 2b/3 pediatric studies (measurements: aPTT 2,925 [N = 358]; dTT 2,348 [N = 324]; ECT 2,929 [N = 357]) were compared with adult data (5,740 aPTT, 3,472 dTT, 3,817 ECT measurements; N = 1,978). Population models were fitted using nonlinear mixed-effects modeling. Covariates (e.g., sex, age) were assessed on baseline and drug-effect parameters, using a stepwise covariate model-building procedure.
Results Overall, relationships between dabigatran, aPTT, dTT, and ECT were similar in children and adults. For children aged <6 months, a higher proportion of baseline samples were outside or close to the upper aPTT and ECT adult ranges. No age-related differences were detected for dTT. With increasing dabigatran concentration, aPTT rose nonlinearly (half the maximum effect at 368 ng/mL dabigatran) while dTT and ECT increased linearly (0.37 and 0.73% change per ng/mL dabigatran, respectively). Mean baseline aPTT (45 vs. 36 seconds) and ECT (40 vs. 36 seconds) were slightly increased for those aged <6 months versus older children.
Conclusion The similar relationships of laboratory parameters observed across pediatric age groups suggests that developmental changes in the hemostatic system may have little effect on response to dabigatran.
The Anatomic Features and Role of Superficial Inferior Epigastric Vein in Abdominal Flap
Authors: Park Seong Oh , Imanishi Nobuaki , Chang Hak 
Published: August 2022

AbstractIn lower abdominal flap representing transverse rectus abdominis musculocutaneous (TRAM) flap or deep inferior epigastric perforator (DIEP) flap, superficial inferior epigastric vein (SIEV) exists as superficial and independent venous system from deep system. The superficial venous drainage is dominant despite a dominant deep arterial supply in anterior abdominal wall. As TRAM or DIEP flaps began to be widely used for breast reconstruction, venous congestion issue has been arisen. Many clinical series in regard to venous congestion despite patent microvascular anastomosis site were reported. Venous congestion could be divided in two conditions by the area of venous congestion and each condition is from different anatomical causes. First, if venous congestion was shown in whole flap, it is due to the connection between SIEV and vena comitantes of DIEP. Second, if venous congestion is limited in above midline (Hartrampf zone II), it is due to problem in venous midline crossover. In this article, the authors reviewed the role of SIEV in lower abdominal flap based on the various anatomic and clinical studies. The contents are mainly categorized into four main issues; basic anatomy of SIEV, the two cause of venous congestion, connection between SIEV and vena comitantes of DIEP, and midline crossover of SIEV.