bluuebunny/crossref_metadata_2025_split huggingface dataset:
SOSIALISASI PEMANFAATAN SAMPAH ORGANIK BERNILAI EKONOMIS DENGAN BUDIDAYA MAGGOT DI KECAMATAN TANAH PUTIH, ROKAN HILIR
Authors: Misdawita Misdawita , Zamaya Yelly , Zuryani Hilmah 
Published: September 2022

Permasalahan pengelolaan sampah masih menjadi tantangan besar bagi Provinsi Riau, yaitu volume sampah yang semakin meningkat. Di Kecamatan Tanah Putih Kabupaten Rokan Hilir Provinsi Riau hasil pertanian dan perkebunan rakyat dijual oleh pedagang di pasar yang diadakan secara bergantian di setiap desa. Namun, di pasar tersebut banyak sampah dari penjualan sayuran dan buahan yang terbuang dan dihanyutkan ke sungai rokan oleh karena itu diperlukan pengelolaan sampah organik tersebut agar dapat bernilai ekonomis bagi para pedagang. Salah satu cara pengelolaan sampah yang baik yaitu dengan cara memanfaatkannya sebagai media budi daya Maggot. Maggot merupakan larva dari lalat Black Soldier Fly (BSF). Hasil dari budidayya Maggot ini dapat menjadi bahan pakan ternak, karena maggot memiliki protein yang tinggi Metode pada pengabdian ini adalah berupa sosialisasi tentang bagaimana mengolah sampah organik menggunakan budidaya maggot agar hasilnya dapat dimanfaatkan oleh para peternak. Tujuan kegiatan ini untuk memberikan pengetahuan kepada pedagang tentang pemanfaatan sampah organik dengan memanfaatkan budidaya Maggot. Hasil kegiatan ini adanya peningkatan pengetahuan masyarakat khususnya pedagang sayuran dan buahan tentang pemanfaatan sampah organik. Berdasarkan kegiatan yang telah dilakukan maka dapat disimpulkan bahwa harus adanya pelatihan lanjutan dalam pengelolaan sampah organik dengan budidaya maggot lalat BSF, agar pedagang memiliki kemampuan dalam mengelola sampah organik.
SOSIALISASI PROSEDUR OPERASI STANDAR UMUM PENANGANAN BARANG BERBAHAYA PADA PENERBANGAN BERDASARKAN PERATURAN NASIONAL DAN INTERNASIONAL
Authors: Rizaldy Wynd , Lesmini Lis , Sembiring Honny Fiva Akira , Chairuddin Irwan , Marina Sandriana 
Published: September 2022

Tujuan kegiatan pengabdian kepada masyarakat ini untuk memberikan sosialisasi terkait pentingnya sertifikasi dan penyusunan prosedur operasi standar (SOP) Umum penanganan barang berbahaya umum pada maskapai penerbangan secara langsung atau melalui ground handling sebagai perwakilan penerbangan di Indonesia. Kegiatan pengabdian ini dilaksanakan pada tanggal 25 Februari 2022 melalui zoom meeting kepada mitra pengabdian yaitu maskapai penerbangan Air Asia. Metode yang digunakan dalam kegiatan pelaksanaan pengabdian ini yaitu dengan melakukan sosialisasi menggunakan pendekatan perbincangan santai namun terarah dengan media daring kepada mitra maskapai penerbangan ataupun stake holder yang memerlukan. Hasil dari pengabdian ini adalah pemahaman masyarakat transportasi atau personel penerbangan sebesar 23,86% rata-rata peningkatan dari 69,46% ke 93,32% yang didapat dari pre dan post test terhadap 19 peserta mengenai prosedur penyusunan SOP untuk memperoleh sertifikasi pengangkutan barang berbahaya di Indonesia.
Development of Orodispersible Ibuprofen Tablets Based on a Polymer-drug Complex
Authors: Timergalieva V. R. , Khusnutdinov R. R. , Musina R. R. , Elizarova E. S. , Alsynbaev R. R. , Nasibullin Sh. F. , Moustafine R. I. 
Published: September 2022

Introduction. Orodispersible dosage forms are a very promising direction in the development of dosage forms. Such dosage forms are designed for both systemic and local action of the active pharmaceutical ingredients that make up their composition. Active pharmaceutical ingredients from orodispersible forms enter directly into the systemic circulation, bypassing the "first pass effect".Aim. Development of orodispersible tablets based on the Eudragit® EPO/ibuprofen polymer-drug complex and evaluation of ibuprofen release from the resulting system.Materials and methods. Samples of the polymer-drug complex (PDC) were obtained with different ratios of EPO and ibuprofen, as well as with different mixing orders. Turbidimetric studies to find the stoichiometry of the resulting EPO/IB PLC were performed spectrophotometrically (Lambda 25, PerkinElmer, U.S.A.) at a wavelength of 600 nm. Thermal analysis was performed by modulation differential scanning calorimetry (mDSC) on a Discovery™ DSC instrument (TA Instruments, U.S.A.). Samples sealed in Tzero aluminum pans (TA Instruments, U.S.A.) were scanned in the temperature range from 0 to 250 °С at a speed of 2 °С/min. IR spectra were recorded on a Nicolet iS5 FT-IR spectrometer (Thermo Fisher Scientific, U.S.A.) with an ATR nozzle, in the range from 500 to 4000 cm-1. Drying of samples of complexes and dispersible tablets was carried out in a FreeZone 1L laboratory freeze dryer (Labconco, U.S.A.) for a 24 hours at a temperature of –49 °C and at a pressure of 0.350 mbar. The drug release was evaluated on a dissolution tester DT 828 (ERWEKA GmbH, Germany) in a volume of 900 ml, at 37 ± 0.5 °C and a blade rotation speed of 50 rpm.Results and discussion. Studies on the formation of PDC Eudragit® EPO/ibuprofen (EPO/IB) were carried out at various molar ratios. On samples of PDC and individual components, bands are observed that are characteristic both for EPO – at 2770 and 2820 cm-1, confirming the presence of non-ionized dimethylamino groups, and at 1725 cm-1, corresponding to the stretching vibrations of carboxyl groups. A new band is appeared at 1573 cm-1, which confirm the formation of ionic bonds between carboxylate groups of IB and ionized dimethylamino groups of EPO. The mDSC thermograms of the samples are characterized by a single glass transition temperature (Tg) at 27,3 ± 0,3 °С (for molar ratio 1 : 2) and 44,9 ± 0,4 °С. (for molar ratio 1 : 1), which confirm the formation of polymer-drug complexes. Received PDC Eudragit® EPO/ibuprofen in a molar ratio of 1 : 2 and 1 : 1 and oral dispersible tablets based on them by lyophilization. The resulting systems are characterized by immediate release of IB with maximum rates at 30 min for a 1 : 1 composition and 60 min for a 1 : 2 composition.Conclusion. Eudragit® EPO/ibuprofen polymer drug complex can be used to develop orodispersible tablets providing immediate release of IB.
Development of the Composition of Combined Medicinal Pencils for the Treatment of Dental Diseases
Authors: Alekseeva I. V. , Ryumina T. E. , Novikova V. V. , Golovanenko A. L. , Kotsur Yu. M. , Shigarova L. V. 
Published: September 2022

Introduction. Prevention and treatment of periodontal diseases remains one of the urgent problems of modern medicine. According to WHO, the prevalence of dental diseases among adults is 90–95 %, among adolescents – 80–83 %. The health of the body as a whole largely depends on the state of the oral cavity. It is important for the effective treatment of diseases to have a properly selected dosage form, which provides both convenience of use and purposeful use of the action of the pharmacologically active drug contained in it. Medicinal pencils as a dosage form are very limited on the pharmaceutical market, so their development is relevant. As a local anesthetic component, anilocaine is included in the composition of pencils at a concentration of 5 %, antimicrobial action is provided by the introduction of metronidazole in a concentration of 1 % in order to prevent the occurrence of infection.Aim. Substantiation of the composition and technology of the medicinal pencil for the treatment and prevention of infectious and inflammatory diseases of the oral cavity.Materials and methods. For the study, we used medicinal pencils with an active pharmaceutical substance – anilocaine (FS 42-2846-97, LLC "Perm Chemical Company", Perm, shelf life of 5 years), metronidazole (FS 42-0257-07, JSC "Medisorb", Perm, shelf life of 3 years); basic components – PEO-400 (FS 42-1242-96, LLC "Neftegazkhimkomplekt", Moscow, shelf life of 3 years), PEO-1500 (FS 42-1885-96, LLC "Neftegazkhimkomplekt", Moscow, shelf life of 3 years), PEO-4000 (FS 42-3337-96, LLC "Neftegazkhimkomplekt", Moscow, shelf life 3 years), second ingredient – purified water (FS.2.2.0020.18), the UVOI-"MF" 1812S6 obtained at the reverse osmosis plant (JSC "NPK Median-Filter", Russia). In the course of the research, technological, structural-mechanical and biopharmaceutical methods were used.Results and discussion. Based on technological, structural-mechanical and biopharmaceutical studies, the composition of medicinal pencils with anesthetic, anti-inflammatory and antimicrobial effects for the treatment and prevention of infectious and inflammatory diseases of the oral cavity is proposed and justified for the first time. Biopharmaceutical availability of medicinal pencils is determined by the conductometric method.Conclusion. The conducted complex of studies will expand the range of domestic medicines for the treatment and prevention of infectious and inflammatory diseases of the oral cavity.
Rationing of Residual Organophosphate Pesticides in Herbal Substances (Review)
Authors: Fateenkova O. V. , Savvateev A. M. , Beloborodov V. L. , Gravel I. V. 
Published: September 2022

Introduction. Usage of organophosphate pesticides (OPPs) in agriculture, including farming of medical herbs, is a necessary measure for producing regular harvest. In order to maintain an adequate degree of herbal medicines security a variety of countries developed normative documents that regulate the limits of proportion of pesticides (including OPPs) in herbal substances. These documents contain the recommended methods of residual pesticides analysis as well.Text. The article describes the recently conducted information-analytical research of limits of permissible proportion of OPPs in herbal substances and food production and of methods of extraction and analysis of OPPs mentioned in the State Pharmacopoeia of the Russian Federation XIV, international pharmacopeias, WHO information sources and the normative documents on food production. The authors specify physical-chemical characteristic of OPPs and the main mechanism of impact of this class of pesticides onto a human body. The research demonstrates that HPLC-MS and GC-MS are the most perspective analytical methods of detection of OPPs in herbal substances.Conclusion. In the information-analytical review the authors specify a physical-chemical characteristics of OPPs, describe the mechanism of the toxic impact of this type of pesticides, provide the generalized summary of limits of permissible proportion of OPPs in herbal substances and in food production. The study shows that the rationing of OPPs proportion is harmonized in a majority of issues of modern pharmacopeias. The paper presents modern methods of detection of OPPs in herbal substances and food production. Finally, the authors demonstrate an advantage of the modern approach to rationing of OPPs in herbal substances (specification of presence and proportion of a single pesticide in combination with its toxic metabolites). The key issue is a necessity of developing a sensible and selective methodic of analysis of OPPs in accordance with physical-chemical properties of these types of pesticides in different kinds of herbal substances and phytopreparations.
Current aspects of Quality Control and Standardization of <I>Eleutherococcus senticosus</I> Medicines
Authors: Kurkin V. A. , Ryazanova T. K. 
Published: September 2022

Introduction. Nowadays, herbal medicines are becoming more and more popular. In this regard, herbal medicinal preparations based on rhizomes and roots of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim., syn. Acanthopanax senticosus (Rupr. & Maxim.) Harms, are of particular interest. Its have an adaptogenic, immunomodulatory effects mainly due to the presence of phenyl propane compounds: eleutherosides B, D, E, E1. The current pharmacopeial monographs FS.2.5.0053.15 "Eleutherococcus senticosus rhizomes and roots" and FS.3.4.0009.18 "Eleutherococcus senticosus rhizomes and roots liquid extract" in The State Pharmacopoeia of the Russian Federation XIV Edition, in our opinion, does not allow to fully objectively and uniformly assess the quality of raw materials and preparations.Aim. The aim is substantiation of new approaches to quality control of raw materials and preparations of Eleutherococcus senticosus, consisting in changing the conditions of sample preparation and analysis of active biological compounds in comparison with pharmacopoeial methods.Materials and methods. Samples of the medicinal preparation "Eleutherococcus extract liquid" of a domestic manufacturer (5 lots) and experimental preparation "Eleutherococcus syrup". When performing high performance liquid chromatography (HPLC) analysis, a reference sample of syringin was used that met the requirements of pharmacopeial monograph VFS 42-2088-92. Methods of UV-spectroscopy and HPLC were used to determine the quantity of biologically active substances.Results and discussion. As a result of the research, other methodological and methodological approaches have been developed to determine the content of the total of phenylpropanoids in terms of eleutheroside B (syringin) by direct UV-spectrophotometry using a standard sample of syringin or the value of its specific absorbance. New conditions for HPLC analysis of eleutheroside B (syringin) in preparations of Eleutherococcus senticosus have been selected.Conclusion. As a result of the phytochemical study, a spectrophotometric method was developed for the determination of the total of phenylpropanoids in terms of syringin and an HPLC method for the determination of eleutheroside B (syringin) using an external standard after preliminary purification of the total extracts by filtration through a layer of aluminum oxide.
Screening of Lipophilic Fractions of Botanical Forms of Celery by GC/MS Method
Authors: Surbeeva E. S. , Sipkina N. Y. , Komova S. I. , Efremova U. A. , Terninko I. I. 
Published: September 2022

Introduction. The search for new tools for the treatment and prevention of obesity – a socially significant disease characterized by high prevalence and the presence of a number of complications – is an urgent area of research. Literature data indicate the presence of pharmacological activity in different groups of BAC of plant origin – flavonoids, phenolic acids, phytosterols, etc. in relation to obesity and its associated diseases. In view of the significant accumulation of target groups of compounds, as well as the availability of a large and renewable raw material base, celery was chosen for research as a potential raw source of BAC contributing to the regulation of metabolic disorders.Aim. To investigate the component composition of lipophilic fractions of botanical forms of celery by GC/MS and to predict the pharmacological activity of identified compounds within the target group of pathologies using the web resource PASS Оnline.Materials and methods. Lipophilic fractions were prepared by chloroform extraction of dry crushed raw material of celery root, stalks and leaves in a Soxhlet apparatus. Obtained extracts were analyzed on gas chromatography-mass spectrometer "Clarus 600T" (PerkinElmer, USA) on the basis of the Collaborative Centre "Analytical Center" equipment. Interpretation of the mass spectra of the peaks on the chromatograms was carried out using the NIST-14 library, for further prediction of biological activity of the identified compounds we used web-resource PASS online.Results and discussion. The composition of lipophilic fractions of celery botanical forms is represented by terpenes, benzofurans, coumarins, fatty acids and their derivatives, phytosterols. A total of 50 compounds were found in extracts from celery root, of which 68 % were identified, stalks – 36 and 61 %; leaves – 22 and 64 %, respectively. Prediction of the pharmacological activity of individual compounds of celery showed the possibility of their use for the regulation of lipid and carbohydrate metabolism, cardiovascular disorders and liver diseases, which confirms the prospects of this study.Conclusion. The results have shown that celery roots and stalks are a source of terpenes, coumarins and benzofuran derivatives, in addition, the above-ground part of the plant shows high accumulation of phytosterols, which may have metabolic regulation activity and be used in the complex therapy and prevention of obesity.
Development and Validation of HPLC-UV Method for the Determination of Favipiravir in Human Plasma
Authors: Komarov T. N. , Karnakova P. K. , Archakova O. A. , Shchelgacheva D. S. , Bagaeva N. S. , Shohin I. E. , Zaslavskaya K. Ya. , Bely P. A. 
Published: September 2022

Introduction. Coronavirus disease (COVID-19) is an acute infectious disease caused by SARS-CoV-2 (severe acute respiratory syndrome-related coronavirus 2). Favipiravir is a synthetic prodrug with antiviral activity used for the treatment of COVID-19. There are oral and parenteral dosage forms of favipiravir. Compared with oral administration, parenteral administration has some advantages. Developing a method for the determination of favipiravir in human blood plasma is necessary for performing the analytical part of clinical studies of favipiravir for parenteral administration as an infusion, studying pharmacokinetics, and choosing the optimal dosage of the drug.Aim. The aim of this study is to develop and validate a method for quantitative determination of favipiravir in human plasma by high-performance liquid chromatography with ultraviolet detection (HPLC-UV) for pharmacokinetic studies.Materials and methods. Determination of favipiravir in human plasma by HPLC-UV. The UV detection was set at 323 ± 2 nm. The samples were processed by methanol protein precipitation. Internal standard: raltegravir. Mobile phase: 0.1 % formic acid in water with 0.08 % aqueous ammonia (eluent A), 0.1 % formic acid in acetonitrile with 0.08 % aqueous ammonia (eluent B). Column: Phenomenex Kinetex®, C18, 150 × 4.6 mm, 5 μm. Analytical range: 0.25–200.00 μg/mL.Results and discussion. This method was validated by selectivity, calibration curve, accuracy, precision, spike recovery, the lower limit of quantification, carry-over effect and stability.Conclusion. We developed and validated the method of quantitative determination of favipiravir in human plasma by HPLC-UV. The analytical range was 0.25–200.00 μg/mL in human plasma. The method could be applied in pharmacokinetics studies of favipiravir.
Natural Deep Eutectic Solvents as Alternative Flavonoid Extractants from the Sedative Plant Composition
Authors: Dzhavakhyan M. A. , Prozhogina Yu. E. , Pavelieva O. K. , Kalenikova E. I. 
Published: September 2022

Introduction. Natural deep eutectic solvents (DESs) are promising extractants for many biologically active substances from plant raw materials. They are biodegradable, safe, stable, their production is affordable and easily feasible, and the extraction efficiency is comparable to known organic solvents. In this regard, interest in deep eutectic solvents has been steadily growing in recent years, and they are being used in various fields of chemistry, pharmaceuticals and the food industry.Aim. The purpose of this work was to study the possibility of extracting flavonoids from plant raw materials using deep eutectic solvents, as well as to compare the efficiency of their extraction with traditional solvents.Materials and methods. The extraction of flavonoids was carried out from the collection of a plant composition consisting of the herb of motherwort cordial (common motherwort) (Leonurus cardiaca L.), the herb of St. John's wort (Hypericum perforatum L.), the herb of lemon balm (Melissa officinalis L.) and the herb of creeping thyme (thyme) (Thymus serpyllum L.) in a ratio of 4 : 2.5 : 2.5 : 1, crushed to a particle size of 2–3 mm. 21 eutectic solvents based on betaine hydrochloride and choline bitartrate as hydrogen bond acceptors were used as extractants.Results and discussion. The extracting ability of 21 experimental compositions of DESs was studied. The influence of the water content in the composition of DES, as well as the effect of temperature on the extraction process, has been studied. Quantitative determination of flavonoids in terms of rutin was carried out by differential spectrophotometry at a wavelength of 410 ± 2 nm. The maximum yield of flavonoids was achieved using a 40 % aqueous solution of DES based on betaine hydrochloride and propylene glycol in a molar ratio of 1 : 3 at 60 °C.Conclusion. The recovery ability of the obtained DES is comparable in efficiency and even slightly exceeds that of the classic extractant for the investigated composition – 70 % ethyl alcohol. Further development and optimization of the process of using DESs is a promising direction for the development of chemistry and pharmaceutical technology.
Body growth assessment in children with IgE-mediated cow's milk protein allergy fed with a new amino acid-based formula
Authors: Nocerino Rita , Coppola Serena , Carucci Laura , Paparo Lorella , De Giovanni Di Santa Severina Anna Fiorenza , Berni Canani Roberto 
Published: September 2022

BackgroundAmino acid-based formula (AAF) is a relevant dietary option for non-breastfed children. The present study was designed to evaluate the body growth pattern in cow's milk protein allergy (CMPA) children treated for 6 months with a new AAF.MethodsThis was an open-label, single arm study evaluating body growth pattern in immunoglobulin E (IgE)-mediated CMPA infants receiving a new AAF for 6 months. The outcomes were anthropometry (weight, length, head circumference), adherence to the study formula and occurrence of adverse events (AEs).ResultsFifteen children [all Caucasian and born at term; 53.3% born with spontaneous delivery; 80% male; 80% with familial allergy risk; mean age (±SD) 3 ± 2.5 months at IgE-mediated CMPA diagnosis; mean age (±SD) 16.7 ± 5.9 months at enrolment, mean total serum IgE (±SD) 298.2 ± 200.4 kU/L] were included and completed the 6-month study. Data from fifteen age- and sex-matched healthy controls were also adopted as comparison. At baseline, all CMPA patients were weaned and were receiving the new AAF. All 15 patients completed the 6-month study period. For the entire CMPA pediatric patients’ cohort, from baseline to the end of the study period, the body growth pattern resulted within the normal range of World Health Organization (WHO) growth references and resulted similar to healthy controls anthropometric values. The formula was well tolerated. The adherence was optimal and no AEs related to AAF use were reported.ConclusionsThe new AAF ensured normal growth in subjects affected by IgE-mediated CMPA. This formula constitutes another suitable safe option for the management of pediatric patients affected by CMPA.