bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement in the quality of life of outpatients with severe mental illness in conjunction with intellectual disabilities and post‐traumatic stress disorder
Authors: Smits Hedwig J. H. , Seelen‐de Lang Birgit L. , Penterman Engelbertus J. M. , Nijman Henk L. I. , Noorthoorn Eric O. 
Published: September 2022

AbstractBackgroundElucidating the influence of mild intellectual disability (MID; IQ 50–70)/borderline intellectual functioning (BIF; IQ 70–85) and (comorbid) post‐traumatic stress disorder (PTSD) on the quality of life of patients with serious mental illness (SMI) could improve their mental health care.MethodThis study comprises a prospective longitudinal cohort study using routine outcome monitoring data. The cohort comprised 601 patients who had undertaken at least one Manchester Short Assessment of Quality of Life (MANSA). The scores for screeners to detect MID/BIF and PTSD were analysed, and a repeated measures analysis of variance and a multi‐level linear regression was performed on the MANSA scores.ResultsThe average quality of life for all patient groups increased significantly over time. A between‐subject effect on quality of life was observed for PTSD, but not MID/BIF.ConclusionsPTSD but not MID/BIF is associated with a lesser quality of life over time.
Patient‐rated satisfaction and improvement following hip and knee replacements: Development of prediction models
Authors: Appiah Karen O. B. , Khunti Kamlesh , Kelly Benjamin M. , Innes Aidan Q. , Liao Zhining , Dymond Michael , Middleton Robert G. , Wainwright Thomas W. , Yates Thomas , Zaccardi Francesco 
Published: September 2022

AbstractRationaleEffective preoperative assessments of determinants of health status and function may improve postoperative outcomes.Aims and ObjectivesWe developed risk scores of preoperative patient factors and patient‐reported outcome measures (PROMs) as predictors of patient‐rated satisfaction and improvement following hip and knee replacements.Patients and MethodsProspectively collected National Health Service and independent sector patient data (n = 30,457), including patients' self‐reported demographics, comorbidities, PROMs (Oxford Hip/Knee score (OHS/OKS) and European Quality of Life (EQ5D index and health‐scale), were analysed. Outcomes were defined as patient‐reported satisfaction and improvement following surgery at 7‐month follow‐up. Univariable and multivariable‐adjusted logistic regressions were undertaken to build prediction models; model discrimination was evaluated with the concordance index (c‐index) and nomograms were developed to allow the estimation of probabilities.ResultsOf the 14,651 subjects with responses for satisfaction following hip replacements 564 (3.8%) reported dissatisfaction, and 1433 (9.2%) of the 15,560 following knee replacement reported dissatisfaction. A total of 14,662 had responses for perceived improvement following hip replacement (lack of improvement in 391; 2.7%) and 15,588 following knee replacement (lack of improvements in 1092; 7.0%). Patients reporting poor outcomes had worse preoperative PROMs. Several factors, including age, gender, patient comorbidities and EQ5D, were included in the final prediction models: C‐indices of these models were 0.613 and 0.618 for dissatisfaction and lack of improvement, respectively, for hip replacement and 0.614 and 0.598, respectively, for knee replacement.ConclusionsUsing easily accessible preoperative patient factors, including PROMs, we developed models which may help predict dissatisfaction and lack of improvement following hip and knee replacements and facilitate risk stratification and decision‐making processes.
The BLOODSAFE program: Building the future of access to safe blood in Sub‐Saharan Africa
Authors: Delaney Meghan , Telke Susan , Zou Shimian , Williams Makeda J. , Aridi Jackline O. , Rudd Kristina E. , Puyana Juan Carlos , Kumar Pratap , Appiah Bernard , Dei‐Adomakoh Yvonne , Asamoah‐Akuoko Lucy , Olayemi Edeghonghon , Singogo Emmanuel , Hosseinipour Mina C. , M'baya Bridon , Chipeta Effie , Reilly Cavan ,   BLOODSAFE Program Investigators, Kamu Robert , Aridi Jackline , Munoz‐Valencia Alejandro , Raykar Nakul , Barnes Linda , Makin Jennifer , Bidanda Bopaya , Yazer Mark H. , MacLeod Jana , Muiri Carolyne Nkoki , Olayo Bernard , Murithi Gatwiri , Rajgopal Jayant , Tian Yiqi , Zeng Bo , Kivuli Tecla , Mate Muthoni , Musa Abdirahaman , Mical Cindy , Nyagol Hellen , Ochieng Kevin , Epuu Tonny , Kuma Amma Benneh‐Akwasi , Segbefia Catherine , Yawson Alfred , Adu‐Afarwuah Seth , Adongo Phillip , Acquah Michael , Tancred Tara , Dei Emmanuel Nene , Bates Imelda , Ofori‐Acquah Solomon , Ansah Justina Kordai , John‐Teye Dilys , Cohn Claudia , Chu Haitao , Burns Adam , Croal Mitch , Eckroth Kate , Van Ryn Collin , Chiwindo Titus , Mwapasa Victor , Muula Adamson , Mhango Patani , Kayira Princess , Likaka Andrew , Dzama Wilfred , Nsamala Natasha , Kadewere Geoffrey , Joshua Martias 
Published: September 2022

AbstractBackgroundThe supply of blood in many low‐ and middle‐income nations in Sub‐Saharan Africa (SSA) does not meet the patient care needs. Lack and delay of blood transfusion cause harm to patients and slow the rate of progress in other parts of the health system. Recognizing the power of implementation science, the BLOODSAFE Program was initiated which supports three SSA research study teams and one data coordinating center (DCC) with the goal to improve access to safe blood transfusion in SSA.Study Design and MethodsThe study team in Ghana is focusing on studying and decreasing iron deficiency in blood donors and evaluating social engagement of blood donors through different approaches. The study team in Kenya is building a “vein to vein” workflow model to elucidate and devise strategies to overcome barriers to blood donation and improve infrastructural components of blood product production and use. The Malawi team is studying the infectious disease ramifications of blood donation as well as blood donor retention strategies aimed at blood donors who commence their donation career in secondary schools.Results and DiscussionTogether the project teams and the DCC work as a consortium to support each other through a shared study protocol that will study donor motivations, outcomes, and adverse events across all three countries. The BLOODSAFE Program has the potential to lead to generalizable improvement approaches for increasing access to safe blood in SSA as well as mentoring and building the research capacity and careers of many investigators.
Effect of System Mode and Structural Damping Perturbation on the Mistuned Forced Response and Aerodynamic Damping of Embedded Compressor Rotors
Authors: Hegde Shreyas , Inge Jonathan D. , Kielb Robert 
Published: September 2022

Abstract
This paper is a continuation of previous papers by the authors that focuses on predicting the mistuned embedded rotor blade forced response. The compressor under consideration is a part of a 3.5stage rig located at Purdue University. Previously, the current authors have discussed the impact of sideband traveling wave forcing functions on the mistuned response and pinned down the reason for a constant underprediction in the amplification factor. This prompted further research to determine the sensitivity of the response to a known change in the system mode. In the first section of the current paper, the authors perturb the system modes frequencies in a probabilistic manner and compute the influence of the system mode on the mistuning amplification factor. The second part of this study involves determining the impact of a perturbation in the structural damping on the mistuned response. The study is also extended to an aerodynamic dynamic analysis wherein the impact of a perturbation in system mode frequency and structural damping is determined both individually and as a combined influence. Finally, a brief investigation of system eigenvalues and eigenvectors is conducted to understand the impact of mistuning on aerodynamic damping suppression. This analysis is joined with a broad examination of the relationship between damping and the extent of mistuning. The key conclusions from this paper are (1) the mistuned forced response was highly sensitive to the system mode input, i.e., although the input was probabilistic, the output was deterministic, (2) since the aerodynamic damping dominates in the case study, a change in the structural damping parameter has minimal effect on the mistuned response, particularly the mistuning amplification factor, (3) the results of the flutter analysis show that a perturbation in the system mode frequency stabilizes the system much faster than a perturbation in the structural damping, and the latter has minimal influence on the eigenvalues of the solution, (4) under the application of mistuning, compression of the damping components of the complex eigenvalues is dominant over the expansion of the frequency components and is amplified when the structural coupling is not considered, and (5) in cases of both random and near alternate blade mistuning, the relationship between mistuning and damping is positive up to a point, after which further increasing mistuning begins to reduce system damping.
Supplemental Material: Strategies for effective unmanned aerial vehicle use in geological field studies based on cognitive science principles
Authors: Bateman Kathryn M. , al. et 
Published: September 2022

<p>Item 1: Field-Based UAV Protocol for Geoscientists. Used in the Mecca Hills with field geologists at three locations. Provides goals, instructions to the geologist, and questions asked of them before, during, and after their flights. Item 2: AV Geoscience User Survey. Administered to expert geoscientists attending a UAV operators group town hall at the 2019 American Geophysical Union (AGU) meeting. </p>
Archeology of Distinctiveness: the Material World of Muscovy of the 14th–16th Centuries
Authors: Belyaev L. A. 
Published: September 2022

Abstract
The paper sets as its goal to take a closer look at heritage of Muscovite Russia from the archeological perspective, while presenting it as an archeological culture of a kind with the inherent distinctiveness. It considers the origin of Muscovite culture after the Horde invasion and a number of case studies from the fields of architecture, ornament, funerary customs, and crafts. The end of the 14th–early 15th century marks out a chronological threshold, crossing which this “archeological culture” can be deemed self-contained. The concepts are refined with respect to the genesis of a sarcophagus and gravestone slab. The paper assesses a role of the Eastern (Islam), Eastern Christian, and West European impulses in the development of material culture of “Muscovy.”
Wine at the Feasts of Moscow Sovereigns in the 16th–17th Centuries
Authors: Petrov D. A. 
Published: September 2022

Abstract
The extent of wine in Muscovy, primarily in the palace economy, is considered. On the basis of a comparison of materials from Russian records management and notes of foreigners, the use of wine in the embassy ceremonies (primarily at the reception of the ambassadors of the King of England in 1664) and in the celebration of important events in the life of the Russian society elite is elucidated. The problem of centralized importation, internal trade, and storage of wine is touched upon. The varieties of alcoholic beverages common in Russia are studied separately. The author comes to the conclusion that there had been a fairly wide range of wine varieties in Russia, despite the fact that tastes did not fundamentally change and the wine menu had been relatively stable for many decades.
Zigzags of the Post-Imperial Syndrome
Authors: Garbuzov V. N. 
Published: September 2022

Abstract
The death of every empire is always painful and often turns into tragedy. It inevitably entails painful processes: the rupture of habitual economic ties, the loss of vast territories and spheres of influence, the formation of new states and the definition of borders between them, the emergence of national minorities on the territory of neighbors, etc. However, perhaps the most painful result is the sense of loss of self-worth, a complex of lost greatness that develops into the so-called post-imperial syndrome. In the 20th century, it manifested itself in Germany, Great Britain, France, Austria, Spain, Portugal, Turkey, and former metropolises, which, with the loss of their colonies, lost not only established ties but also geopolitical influence, and with it their former imperial power. In the first quarter of the 21st century, Russia also has had to face the post-imperial syndrome. This article is devoted to its manifestations at this time.
Position of Joe Biden’s Administration on the World Trade Organization
Authors: Menshikova A. M. 
Published: September 2022

Abstract
The election of Democratic Party candidate Joe Biden as President of the United States did not change Washington’s negative attitude towards the activities of the World Trade Organization (WTO). The historically established consensus of the Republican and Democratic parties, expressed in the general similarity of the approach of the legislative and executive branches of the U.S. government to the WTO as a tool primarily for realizing U.S. national interests in the foreign economic sphere, hinders the achievement of generally acceptable agreements within the WTO in key areas of its activities. Like the previous administration of Donald Trump, Joe Biden’s administration has, in particular, been blocking the activities of the WTO’s Appellate Body for a number of years. Despite the Democratic President’s statements about the commitment of the United States to the principles of liberal trade, the White House, as before, proceeds from the desire to maintain the leading role of the United States in the WTO, even at the cost of curtailing certain areas of its work. The dominant desire is to transform the WTO into an international economic mechanism to strategically contain China and openly oppose Russia by politicizing the WTO and taking measures that pave the way for the complete dismantling of the rules-based multilateral trading system. The WTO is in fact in a state of permanent institutional crisis in a number of central areas of its activity. The only way to deal with the current crisis is to give economics precedence, not politics, and prevent violations of agreed multilateral trade rules by unilateral actions; otherwise the negative impact on world markets and the economies of many WTO members will continue.
French Tax for the European Union: The Genesis of Cross-Border Carbon Adjustment
Authors: Roginko S. A. 
Published: September 2022

Abstract
The genesis of the EU initiative of cross-border carbon tax on imported carbon-intensive products is analyzed. An assessment of the positions of the EU countries in relation to this initiative has been given, and the evolution of these positions over the past 25 years has been traced. An analysis has been made of the tactics of France, as the main supporter of the cross-border carbon tax, used to promote this tax on the EU agenda during a number of presidencies, from J. Chirac to E. Macron. The link between the UN climate negotiation process and the EU’s position on the cross-border carbon tax has been clarified. Particular attention was paid to the analysis of the early versions of the EU cross-border carbon tax, which preceded the current version of this initiative, and a comparative study of these versions by the basic parameters of carbon taxation has been conducted.
Clinical prediction models for multidrug-resistant organism colonisation or infection in critically ill patients: a systematic review protocol
Authors: Wang Yi , Xiao Yanyan , Yang Qidi , Wang Fang , Wang Ying , Yuan Cui 
Published: September 2022

IntroductionMultidrug-resistant organisms (MDROs) are pathogenic bacteria that are the leading cause of hospital-acquired infection which is associated with high morbidity and mortality rates in intensive care units, increasing hospitalisation duration and cost. Predicting the risk of MDRO colonisation or infection for critically ill patients supports clinical decision-making. Several models predicting MDRO colonisation or infection have been developed; however, owing to different disease scenarios, bacterial species and few externally validated cohorts in different prediction models; the stability and applicability of these models for MDRO colonisation or infection in critically ill patients are controversial. In addition, there are currently no standardised risk scoring systems to predict MDRO colonisation or infection in critically ill patients. The aim of this systematic review is to summarise and assess models predicting MDRO colonisation or infection in critically ill patients and to compare their predictive performance.Methods and analysisWe will perform a systematic search of PubMed, Cochrane Library, CINAHL, Embase, Web of science, China National Knowledge Infrastructure and Wanfang databases to identify all studies describing the development and/or external validation of models predicting MDRO colonisation or infection in critically ill patients. Two reviewers will independently extract and review the data using the Data Extraction for Systematic Reviews of Prediction Modelling Studies checklist; they will also assess the risk of bias using the Prediction Model Risk of Bias Assessment Tool. Quantitative data on model predictive performance will be synthesised in meta-analyses, as applicable.Ethics and disseminationEthical permissions will not be required because all data will be extracted from published studies. We intend to publish our results in peer-reviewed scientific journals and to present them at international conferences on critical care.PROSPERO registration numberCRD42022274175.
Major elective non-cardiac operations in adults with congenital heart disease
Authors: Williamson Catherine G , Ebrahimian Shayan , Ascandar Nameer , Sanaiha Yas , Sakowitz Sara , Biniwale Reshma M , Benharash Peyman 
Published: September 2022

ObjectiveTo assess the impact of congenital heart disease (CHD) on resource utilisation and clinical outcomes in patients undergoing major elective non-cardiac operations.BackgroundDue to advances in congenital cardiac management in recent years, more patients with CHD are living into adulthood and are requiring non-cardiac operations.MethodsThe 2010–2018 Nationwide Readmissions Database was used to identify all adults undergoing major elective operations (pneumonectomy, hepatectomy, hip replacement, pancreatectomy, abdominal aortic aneurysm repair, colectomy, gastrectomy and oesophagectomy). Multivariable regression models were used to categorise key clinical outcomes.ResultsOf an estimated 4 941 203 adults meeting inclusion criteria, 5234 (0.11%) had a previous diagnosis of CHD. Over the study period, the incidence of CHD increased from 0.06% to 0.17%, p<0.001. CHD patients were on average younger (63.3±14.8 vs 64.4±12.5 years, p=0.004), had a higher Elixhauser Comorbidity Index (3.3±2.2 vs 2.3±1.8, p<0.001) and received operations at high volume centres more frequently (66.6% vs 62.0%, p=0.003). Following risk adjustment, these patients had increased risk of in-hospital mortality (adjusted risk ratio (ARR): 1.76, 95% CI 1.25 to 2.47), experienced longer hospitalisation durations (+1.6 days, 95% CI 1.3 to 2.0) and cost more (+$8370, 95% CI $6686 to $10 055). Furthermore, they were more at risk for in-hospital complications (ARR: 1.24 95% CI 1.17 to 1.31) and endured higher adjusted risk of readmission at 30 days (ARR: 1.32 95% CI 1.13 to 1.54).ConclusionsAdults with CHD are more frequently comprising the major elective operative cohort for non-cardiac cases. Due to the inferior clinical and financial outcomes suffered by this population, perioperative risk stratification may benefit from the inclusion of CHD as a factor that portends unfavourable outcomes.
Multimodality analysis confers a prognostic benefit of a T-cell infiltrated tumor microenvironment and peripheral immune status in patients with melanoma
Authors: Beasley Georgia M , Brown Michael C , Farrow Norma E , Landa Karenia , Al-Rohil Rami N , Selim Maria Angelica , Therien Aaron D , Jung Sin-Ho , Gao Junheng , Boczkowski David , Holl Eda K , Salama April K S , Bigner Darell D , Gromeier Matthias , Nair Smita K 
Published: September 2022

BackgroundWe previously reported results from a phase 1 study testing intratumoral recombinant poliovirus, lerapolturev, in 12 melanoma patients. All 12 patients received anti-PD-1 systemic therapy before lerapolturev, and 11 of these 12 patients also received anti-PD-1 after lerapolturev. In preclinical models lerapolturev induces intratumoral innate inflammation that engages antitumor T cells. In the current study, prelerapolturev and postlerapolturev tumor biopsies and blood were evaluated for biomarkers of response.MethodsThe following analyses were performed on tumor tissue (n=11): (1) flow cytometric assessment of immune cell density, (2) NanoString Digital Spatial profiling of protein and the transcriptome, and (3) bulk RNA sequencing. Immune cell phenotypes and responsiveness to in vitro stimulation, including in vitro lerapolturev challenge, were measured in peripheral blood (n=12).ResultsThree patients who received anti-PD-1 therapy within 30 days of lerapolturev have a current median progression-free survival (PFS) of 2.3 years and had higher CD8+T cell infiltrates in prelerapolturev tumor biopsies relative to that of 7 patients with median PFS of 1.6 months and lower CD8+T cell infiltrates in prelerapolturev tumor biopsies. In peripheral blood, four patients with PFS 2.3 years (including three that received anti-PD-1 therapy within 30 days before lerapolturev and had higher pretreatment tumor CD8+T cell infiltrates) had significantly higher effector memory (CD8+, CCR7-, CD45RA-) but lower CD8+PD-1+ and CD4+PD-1+ cells compared with eight patients with median PFS 1.6 months. In addition, pretreatment blood from the four patients with median PFS 2.3 years had more potent antiviral responses to in vitro lerapolturev challenge compared with eight patients with median PFS 1.6 months.ConclusionAn inflamed pretreatment tumor microenvironment, possibly induced by prior anti-PD-1 therapy and a proficient peripheral blood pretreatment innate immune response (antiviral/interferon signaling) to lerapolturev was associated with long term PFS after intratumoral lerapolturev in a small cohort of patients. These findings imply a link between intratumoral T cell inflammation and peripheral immune function.Trial registration numberNCT03712358.
Some observations and reflections on geodiversity, the oft-forgotten half of nature
Authors: Gray Murray 
Published: September 2022

Abstract
Geodiversity first emerged nearly 30 years ago in the wake of the Convention on Biological Diversity, when geoscientists realized that they too study diverse natural phenomena that are also often threatened with loss or degradation resulting from human activities. Since then, geodiversity has emerged as an important geoscientific paradigm with a central position in the relationships between the geoscientific ‘Gs’ (Geoheritage, Geoconservation, Geoparks, etc). It has spawned much discussion on how geodiversity can be classified and measured; it is often used as the basis for selecting geoheritage sites for geoconservation, including the development of the World Heritage List; it is often used by geoparks to publicize their range of geofeatures; and it is the basis for many ‘geosystem services’ essential to our modern societies. But despite its importance, it is poorly understood and poorly integrated into nature conservation policy and practice. The result is that the value of the whole of nature is underestimated, and the policy and practice for the management of nature lack integration.