bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contrasting responses of control and fibrotic lung fibroblasts to fibrotic stimuli: the role of osteoprotegerin in extracellular matrix remodeling
Authors: Liu Yanzhe , Nizamoglu Mehmet , Zhao Fenghua , Borghuis Theo , Koster Taco , Sharma Prashant K. , Harmsen Martin C. , Thomas Matthew J. , White Eric S. , El Kasmi Karim C. , Heijink Irene H , Melgert Barbro N. , Burgess Janette K. 
Published: February 2025

AbstractIdiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease characterized by dysregulated wound healing, leading to excessive production of extracellular matrix (ECM) proteins, particularly collagen, by activated fibroblasts. Osteoprotegerin (OPG), a soluble protein associated with ECM remodeling in bone, has been found in higher levels in serum and lung tissue of IPF patients compared to controls. However, whether OPG is associated with ECM remodeling by fibroblasts in lung fibrosis remains poorly understood. In this study we assessed differences in OPG levels in ECM-derived hydrogels from non-disease controls and patients with IPF encapsulated with primary human lung fibroblasts from control and patients with IPF (7 days). OPG levels were assessed in a collected culture medium and stained lung tissue sections, and related to biomechanical properties.Fibrotic human lung fibroblasts secreted and deposited more OPG compared to controls, which was observed in both non-diseased and IPF ECM hydrogels. OPG levels correlated significantly with matrix stiffness and collagen fiber structural properties, but only in IPF hydrogels, independent of fibroblast source. Strikingly, we also observed opposite correlations for control and fibrotic fibroblasts in fibrotic hydrogels. Control fibroblasts within a fibrotic microenvironment, secreted less OPG when hydrogel stiffness increased and deposited more OPG when collagen fibers were more aligned. Interestingly, fibrotic fibroblasts secreted more OPG when collagen fiber length increased and when collagen fiber curvature increased. Overall, our findings suggest that control and fibrotic lung fibroblasts exhibited opposite behavior with respect to OPG and ECM remodeling under fibrotic conditions and this may have consequences for matrix stiffness
Dora, a key component of target-directed miRNA degradation, is essential for local genomic amplification inDrosophilaovarian follicle cells
Authors: Akulenko Natalia , Olenkina Oxana , Mikhaleva Elena , Marfina Sofya , Krylova Anastasia , Toshchakov Stepan , Ryazansky Sergei 
Published: February 2025

AbstractThe ubiquitin ligase receptor Dora, theDrosophilahomolog of ZSWIM8, is a key component of the target-directed microRNA degradation (TDMD) pathway. Previous studies have implicated TDMD – and, consequently, ZSWIM8/Dora – in various developmental processes. Here, we investigate the role of Dora inDrosophilaoogenesis, focusing on its function in ovarian somatic cells. We generated a fly strain with an endogenously tagged Dora protein and observed its presence in both germline and somatic follicular cells of the ovaries. Somatic knockdown ofdorarevealed its essential role in normal eggshell formation. Specifically, its loss led to reduced chorion and vitelline transcript levels and decreased chorion gene amplification, both of which are critical for eggshell protein production. Somatic depletion of Dora did not affect the abundance of other known regulators of eggshell formation, including Ttk69, Cut, miR-7 or miR-318 indicating that Dora functions independently of these pathways. Although a direct link between TDMD and chorion eggshell development remains to be confirmed, our findings clearly highlight Dora as a critical regulator in this process. These results pave the way for further investigation into the specific role of TDMD and provide new insights into the regulatory mechanisms underlying animal oogenesis.
Making friends in an asymmetric game: the establishment of male-female grooming exchanges in vervet monkeys
Authors: Tankink Josefien A. , Granell Ruiz Maria , van de Waal Erica , van Schaik Carel , Bshary Redouan 
Published: February 2025

AbstractVarious concepts have been developed to explain cooperation among unrelated individuals, but linking proposed strategies to empirical evidence remains a challenge, especially for variable reciprocal investments. One famous strategy is “raise-the-stakes”, proposing low initial investments but a steady increase if the partner matches the other’s investments or increases their own investments in a series of exchanges. Contrarily, the “making-friends” strategy predicts high investment between strangers that may either be kept up or downregulated if not fully matched. We tested these predictions on grooming exchanges between wild male-female vervet monkeys, a species with regular male dispersal. Contrary to both predictions, females had a consistently high initial investment and groomed immigrants for longer than was reciprocated, showing no adaptation to the formation of debts. However, females gradually reduced grooming over the first 6 months. Males, on the other hand, did not alter grooming investments over time. Thus, grooming exchanges eventually almost evened out. We present various potential explanations for these results, which are overall more consistent with the “making friends” strategy. Most importantly, this study highlights the complexity of real-life cooperation, emphasizing the need for models that explicitly incorporate life history parameters into cooperative strategies.Significance statementThis study demonstrates the importance of considering life-history differences between interaction partners when applying theoretical cooperation models to empirical cases. We examined the development of grooming relationships – a behaviour serving both hygiene and social functions in primates – between newly immigrated male and resident female vervet monkeys. We did not observe a slow building up of exchanges, as predicted by a “raise-the-stakes” strategy. Instead, we found that socially established females heavily invest into grooming immigrant males, without receiving matching returns. These results suggest that female core groups compete with neighboring female core groups over males and the services those provide. Our data highlight avenues for future data-informed theoretical models on cooperation.
Cell-type-specific DNA methylation dynamics in the prenatal and postnatal human cortex
Authors: Franklin Alice , Davies Jonathan P. , Clifton Nicholas E , Blake Georgina E T , Bamford Rosemary , Walker Emma M , Chioza Barry , Frith Martyn , Burrage Joe , Owens Nick , Prabhakar Shyam , Dempster Emma , Hannon Eilis , Mill Jonathan 
Published: February 2025

ABSTRACTThe human cortex undergoes extensive epigenetic remodelling during development, although the precise temporal and cell-type-specific dynamics of DNA methylation remain incompletely understood. In this study, we profiled genome-wide DNA methylation across human cortex tissue from donors aged 6 post-conception weeks (pcw) to 108 years of age. We observed widespread, developmentally regulated, changes in DNA methylation, with pronounced shifts occurring during early- and mid-gestation that were distinct from age-associated modifications in the postnatal cortex. Using fluorescence-activated nuclei sorting (FANS), we optimized a protocol for the isolation of SATB2-positive neuronal nuclei, enabling the identification of cell-type-specific DNA methylation trajectories in developing neuronal and non-neuronal populations. Developmentally dynamic DNA methylation sites were significantly enriched near genes implicated in autism and schizophrenia, supporting a role for epigenetic dysregulation in neurodevelopmental disorders. Our findings underscore the prenatal period as a critical window of epigenomic plasticity in the central nervous system with important implications for understanding the genetic basis of neurodevelopmental phenotypes.
Interplay of magnetocrystalline and magnetoelastic anisotropy in epitaxial
Co(101¯0)
films
Authors: Patel Gauravkumar , Ganss Fabian , Fallarino Lorenzo , Sellge Gabriel , Quintana Mikel , Hübner René , Sander Dirk , Hellwig Olav , Lenz Kilian , Lindner Jürgen 
Published: February 2025

With the goal of creating an in-plane (IP) uniaxial anisotropy system, we deposited a thickness series of epitaxial Co(101¯0) films grown on Si(110) substrates with Ag(110) and Cr(211) buffer layers by magnetron sputtering. However, quantifying the IP magnetic anisotropy using ferromagnetic resonance measurements revealed a much more complex behavior than expected for a simple uniaxial system like hexagonally close-packed (hcp) Co. To understand the experimental results, an in-depth x-ray diffraction analysis of the film structure was performed. Even at a thickness of 100 nm, it revealed an anisotropic strain in the Co films, mainly within the Co basal plane, while the c axis remained mostly unaffected. Calculations show that such unrelaxed strain induces a significant magnetoelastic anisotropy, which counteracts the magnetocrystalline one and, as a result, reduces the overall effective anisotropy. A detailed analysis revealed that mainly the compressive strain along the Co[101¯0] out-of-plane direction is responsible for the observed magnetoelastic anisotropy, while the tensile strain along the Co[1¯21¯0] IP direction only plays a minor role.

Published by the American Physical Society
2025
Steady state, displacement current, and spin polarization for massless fermion in a shear flow
Authors: Lin Shu , Wang Ziyue 
Published: February 2025

We consider spin polarization of massless fermions in a shear flow, whose complete contributions contain magnetization current and side-jump current known from collisional chiral kinetic theory. We argue that the side-jump current adopts interpretation of displacement current. We explicitly determine the displacement current contribution in the steady state reached in shear flow for a quantum electrodynamics (QED) plasma. We find the displacement contribution enhances the magnetization contribution at small and large momenta, but leads to a suppression effect at intermediate momenta. Major differences from previous studies on collisional effect are (i) the fermions are in the same steady state as the medium rather than being probes; (ii) Compton scattering and pair annihilation are also included in addition to the Coulomb scattering considered before.

Published by the American Physical Society
2025
Consistent
N=4
,
D=4
truncation of type IIB supergravity on
S1×S5
Authors: Guarino Adolfo , Sterckx Colin , Trigiante Mario 
Published: February 2025

Fetching techniques from generalized geometry and exceptional field theory, we develop a new method to identify consistent subsectors of four-dimensional gauged maximal supergravities that possess a (locally) geometric embedding in type IIB or 11D supergravity. We show that a subsector that is invariant under a structure group GS⊂E7(7) can define a consistent truncation, even when GS is not part of the symmetry of the gauged maximal supergravity. As an illustration of the method, type IIB supergravity on S1×S5 is shown to admit a consistent truncation to pure N=4, D=4 gauged supergravity. Explicit uplift formulae are presented which provide a type IIB alternative to the M-theory embedding constructed by Cvetic, Lu, and Pope 25 years ago.

Published by the American Physical Society
2025
Out of sight, out of focus: mitigating country-of-origin effects on fashion consumers’ donation behaviour
Authors: Stringer Tara , Alahakoon Thilini , Mathmann Frank , Mortimer Gary , Payne Alice Ruth 
Published: February 2025

PurposeThis study investigates how actual donations towards social causes within fashion supply chains can be increased in the face of negative country-of-origin effects.Design/methodology/approachLiterature reports a lack of sustained consumer support for social causes within fashion supply chains. Driven by perceived psychological distance between the manufacturer and the fashion consumer, negative country-of-origin effects have an impact on donation behaviour. Using two online experiments, this study shows that including a garment worker’s image in swing tags mitigates negative country-of-origin effects on actual donations.FindingsFashion consumers’ actual donations towards worker rights increased with the presence of a garment worker’s image. In the higher psychological distance condition, exposure to the image reduced negative country-of-origin effects, increasing actual donations. This increase in actual donations is driven by pleasure-seeking, thus indicating that consumer support for social causes within fashion supply chains is underlined by hedonism.Originality/valueThis study focuses on a visual cue-based mechanism of promoting actual donations towards social causes and the role of pleasure-seeking in this process – two previously under-explored areas in the fashion marketing literature. The use of an incentive-compatible measure that required participants to donate real money allows the demonstration of actual donation behaviour, providing robust evidence of the impact of visual cues and their potential to be applied in the real-world.
Lost in turbulence? Healthcare workers’ conceptualisations and experiences with navigating time in personalised care
Authors: Corbett Teresa , Meier Ninna , Bridges Jackie 
Published: February 2025

PurposeThe study aims to explore how healthcare workers (HCWs) navigate and experience time when caring for older cancer patients living with other illnesses.Design/methodology/approachThis paper presents findings from a qualitative study of how HCWs conceptualise and navigate the temporal aspects of delivering personalised care to older people living with multimorbidity. Building on research from organisation studies and the sociology of time, we interviewed 19 UK HCWs about their experiences of delivering care to this patient group.FindingsOur findings illustrate how the delivery of personalised care contradicts contemporary models for healthcare delivery defined by efficiency and standardisation. We found that HCWs engage with time as both a valuable commodity to be rationed and prioritised within a constrained context and as a malleable resource for managing workload and overcoming “turbulence” in the system. However, participants in this study also shared how the simultaneous multiplicity and lack of time had a profoundly personal impact on them through the emotional toll associated with “time debt” and “lost” time.Originality/valueThis research presents a unique analysis of how time is conceptualised and navigated in contemporary healthcare, offering valuable insights for policy improvement. We conclude that personalised models of healthcare are incompatible with many current temporal structures of treatment trajectories and work-practices, by nature of being centred around the person and not the system of delivery.
Balancing competing rationales in priority-setting in primary healthcare – an interview study on political governance
Authors: Holmér Suzana , Krevers Barbro , Thomas Kristin , Nedlund Ann-Charlotte 
Published: February 2025

PurposePublicly funded healthcare systems struggle to govern and determine how finite resources should be allocated in relation to political goals within a pre-determined budget. Primary healthcare (PHC) has a central multipurpose function, not least in terms of political strategies, but PHC governance is still largely underexplored. The aim is to explore how politicians responsible for making decisions pertaining to healthcare coverage navigate the governance of public PHC and disentangle it in the form of narratives based on different types of underlying rationales.Design/methodology/approachSemi-structured interviews were conducted with 15 politicians from 3 Swedish regional healthcare authorities. The data were analysed abductively based on scientific, clinical and cultural rationales using thematic content analysis.FindingsOur study provides insights into how PHC’s multipurpose function implicates tensions between politicians' different responsibilities regarding healthcare coverage. It shows how politicians navigate various coexisting rationales, with some being more dominant than others and where tensions also exist between them. In this balancing act, they create narratives addressing different stakeholders and priority-setting dilemmas, reflecting the diverse rationales. Our study reveals that politicians play a crucial role in PHC governance and priorities, balancing rationales that might otherwise become overly dominant.Originality/valueThis paper contributes new knowledge by displaying how politicians balance tensions within and between rationales through different narratives regarding goals/commissions, problematic situations and preferred solutions in PHC governance.
Unveiling the nexus: exploring the relationship between UAE corporate social responsibility laws and employee sustainability
Authors: Al-Tawil Tareq Nael , Rahhal Ala Eddin H. 
Published: February 2025

Purpose
This study aims to examine the corporate social responsibility (CSR)-employee sustainability nexus from a legal perspective, focusing on CSR regulation in the UAE and its impact on workplace well-being, professional development and broader socioeconomic outcomes.

Design/methodology/approach
This study uses a narrative literature review to assess the literature, identify deficits in current knowledge and establish desk research findings on CSR’s effect on employee sustainability, particularly in the legal context of the UAE. This study uses a narrative literature review as the primary research method to analyze the CSR-employee sustainability relationship under UAE CSR legislation.

Findings
A key conclusion drawn from this study is the urgent need to transition CSR compliance from voluntary to mandatory based on legal and moral requirements. Increased transparency is needed not only on the corporate level but also to make real changes regarding employees’ sustainable activities. In this way, social responsibility will be placed into rules and regulations that will ensure corporations are able to advance initiatives that have the potential to foster employee well-being, engagement and long-term career development. This study also emphasizes the need to establish more precise and more enforceable boundaries for CSR. Corporate responsibility should no longer be seen as optional or negotiable but integrated as a fundamental aspect of business operations.

Originality/value
The contributions of this study are twofold. First, it deepens the insight into CSR as the system of governance, which is presented both as the voluntary management system that regulates the company’s relations with the external environment and as the legal framework enforced to address external challenges effectively. Second, it situates employee sustainability in this governance framework as a way of showing how the legal and institutional environments condition CSR-HRM-sustainability relationships. This approach not only fills critical research gaps but also provides actionable insights for policymakers and practitioners seeking to improve organizational sustainability.
Conclusions and reflections: the development of health tourism in challenging times – a focus on the Visegrád countries
Authors: Dryglas Diana , Smith Melanie Kay 
Published: February 2025

PurposeThe purpose of this theme issue is to explore the development of health tourism in challenging times, with a particular focus on the Visegrád countries. The issue investigates the ways in which health tourism enterprises and destinations can enhance resilience, adapt to post-pandemic conditions and navigate economic, social and political uncertainties. Additionally, it highlights the role of health tourism in improving individual and community well-being while aligning with the principles of sustainable development.Design/methodology/approachThis theme issue employs a thematic approach, incorporating both theoretical and empirical perspectives on health tourism development. The research articles included in this issue utilize various qualitative and quantitative methodologies, such as case studies, survey-based research and Delphi studies. The focus is on examining the sustainability and resilience of health tourism enterprises and destinations in the Visegrád countries, drawing on data from key stakeholders, including industry professionals, policymakers and researchers.FindingsThe studies presented in this theme issue identify several critical aspects of health tourism development in the Visegrád region. Key findings include (1) the increasing significance of health tourism as a tool for regional economic development and social well-being; (2) the necessity of infrastructural improvements and service diversification to attract both domestic and international tourists; (3) the role of strategic collaboration between stakeholders, including policymakers, businesses and healthcare institutions, in ensuring the long-term viability of health tourism; (4) the importance of sustainable practices in health tourism management, particularly in light of climate change and resource conservation challenges and (5) the evolving consumer behaviour patterns in the post-pandemic era, which emphasize wellness, preventive healthcare and personalized experiences.Originality/valueThis theme issue contributes to the growing body of literature on health tourism by addressing gaps in research related to the Visegrád countries. It provides novel insights into the resilience and adaptability of health tourism enterprises and destinations in the face of global crises and economic fluctuations. By offering strategic recommendations for policymakers, industry practitioners and researchers, this issue fosters a deeper understanding of how health tourism can drive regional development and support sustainable growth in uncertain times.