bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel approach to characterize the cross‐linking effect of liquid silicone rubber via cavity pressure analysis during injection molding
Authors: Weißer Dennis F. , Mayer Dennis , Schmid Johannes , Deckert Matthias H. 
Published: November 2022

AbstractThe processing of liquid silicone rubber (LSR) in the injection molding process to molded parts offers high economic potential due to its great scalability. Unlike the well‐researched and understood injection molding process of thermoplastics, LSR still lacks basic process knowledge. The cavity pressure curve shows a completely different pattern, as the cold LSR expands strongly once placed in the hot mold due to volume dilation. During processing of LSR exothermic and irreversible cross‐linking, occurs. In this work, a method is introduced to display the cross‐linking reaction in the cavity pressure curve. Using a self‐developed testing device and conventional differential scanning calorimetry measurements, a correlation between cross‐linking and the pressure signal can be demonstrated. A typical deflection is evaluated in the pressure curve by differentiating, which is attributed to the cross‐linking. The relationships established are confirmed by pressure measurements in the mold during the processing of LSR in the injection molding process. The knowledge gained contributes to a better understanding of the process, helps to optimize existing processes and save resources. Existing cavity‐pressure‐measuring‐systems are to be supplemented by an evaluation logic and thus, in addition to cycle time optimization, process variations are to be detected, energy consumption optimized and quality ensured and verified.
Tuning of Microenvironment in Covalent Organic Framework via Fluorination Strategy promotes Selective CO2 Capture
Authors: Das Nitumani , Paul Ratul , Chatterjee Rupak , Shinde Digambar Balaji , Lai Zhiping , Bhaumik Asim , Mondal John 
Published: November 2022

AbstractHerein, we have designed and synthesized two heteroatom (N, O) rich covalent organic frameworks (COF), PD‐COF and TF‐COF, respectively, to demonstrate their relative effect on CO2 adsorption capacity and also CO2/N2 selectivity. Compared to the non‐fluorinated PD‐COF (BET surface area 805 m2 g−1, total pore volume 0.3647 ccg−1), a decrease in BET surface area and also pore volume have been observed for fluorinated TF‐COF due to the incorporation of fluorine to the porous framework (BET surface area 451 m2 g−1, total pore volume 0.2978 ccg−1). This fact leads to an enormous decrease in the CO2 adsorption capacity and CO2/N2 selectivity of TF‐COF, though it shows stronger affinity towards CO2 with a Qst of 37.76 KJ/mol. The more CO2 adsorption capacity by PD‐COF can be attributed to the large specific surface area with considerable amount of micropore volume compared to the TF‐COF. Further, PD‐COF exhibited CO2/N2 selectivity of 16.8, higher than that of TF‐COF (CO2/N2 selectivity 13.4).
Solvent‐mediated single‐crystal‐to‐single‐crystal transformation of metal–organic cage self‐assembly
Authors: Lee Byeongchan , Moon Dohyun , Park Jinhee 
Published: November 2022

AbstractMetal–organic polyhedra (MOPs) are intrinsically porous cage‐like structures; however, they frequently display low porosity due to their agglomeration caused by solvent exchange and removal, which results in the blockage of pore windows. This study presents the unprecedented single‐crystal‐to‐single‐crystal transformation of a cuboctahedral MOP‐OH ([Cu24L24], H2L = 5‐hydroxybenzene‐1,3‐dicarboxylic acid) using a simple solvent exchange from coordinating N,N‐diethylformamide to weakly coordinating chloroform. Following the solvent exchange, the interaction between the cages in the resultant MOP self‐assembly is strengthened while the interaction between the cages and solvents is decreased. The N2 uptake and the surface areas of the MOPs are highly correlated with the cage arrangements: the tightly packed MOPs in chloroform are the most porous among the prepared samples, whereas the loosely packed MOPs are less porous. Scanning electron microscopy reveals that the tight packing of MOPs prevents the crystals from being deteriorating during solvent removal.
Effect of Extraction Time on Origanum onites L. Infusions and Essential Oils – Biological Evaluation, Statistical Principal Component and Hierarchial Cluster Analyses
Authors: Demirci Betül , Kırcı Damla , Öztürk Gözde , Demirci Fatih 
Published: November 2022

AbstractOriganum onites L. of Lamiaceae, is used as a culinary spice and herbal tea; also for its antioxidant, antimicrobial effects among other activities and effects. This research aims to examine the in vitro antimicrobial and antioxidant activities of the infusions and the essential oils (EOs) obtained using different conditions from the aerial parts of the processed and raw of O. onites herbal material. The EOs from O. onites were distilled at different times and characterized both by GC‐FID and GC/MS systems. The resulting main compounds were identified as carvacrol (65.5–91 %), linalool (0.3–17.9 %), γ‐terpinene (2.8–4.6 %), and thymol (0.5–1.5 %), respectively. In addition, Origanum infusions were prepared at four different time intervals, where the volatile compounds of the infusions were analysed using the HS‐SPME‐GC/MS system. Statistical Principal Component (PCA) and Hierarchical Cluster Analyses (HCA) tools were used to demonstrate the composition variations on different times for O. onites infusion and EO samples.
Iridoid Glycosides and Flavonoids Isolated from the Twigs and Leaves of Callicarpa nudiflora and Their Anti‐Inflammatory Activities
Authors: Wang Hao , Dong Hao‐Yan , Liu Yan‐Fang , Liang Ji‐Lei , Liu Hui‐Sheng , Zhao Qin‐Shi , Wei Ping‐He 
Published: November 2022

AbstractA new iridoid glycoside, named 6′‐O‐trans‐feruloyl‐8‐epiloganic acid, together with fifteen known compounds were isolated from the twigs and leaves of Callicarpa nudiflora, a traditional Chinese medicine to treat inflammatory‐related diseases. Their structures were identified by comprehensive spectroscopic analysis and comparison with reported data. Bioassay results revealed that twelve of the isolates could obviously inhibit nitric oxide (NO) production in lipopolysaccharide (LPS)‐induced RAW 264.7 cell lines with IC50 values from 0.64 to 38.72 μM. Among them, compounds 1 (3.27 μM), 6 (5.23 μM), 13 (1.56 μM) and 14 (0.64 μM) exhibited significantly higher activities than that of the positive control (27.13 μM). Additionally, it was supposed that the presence of the carboxy group at the C‐4 position of iridoid glycosides and glycosylation at C‐3 position of flavonoids might impact their inhibitory activities against NO production.
Enhanced Performance via π‐Bridge Alteration of Porphyrin‐Based Donors for All‐Small‐Molecule Organic Solar Cells
Authors: Shen Haojiang , Ren Yi , Li Jianfeng , Xu Yixuan , Han Chenyang , Zou Wentao , Xu Huajun , Sun Yanna , Kan Yuanyuan , Gao Ke 
Published: November 2022

Comprehensive SummaryAll‐small‐molecule organic solar cells (ASM OSCs) are promising for commercial application due to the well‐defined chemical structures, convenient purifying process and low batch‐to‐batch variation. However, the similarity of molecule structures between small molecule donors and acceptors makes a hard regulation of their blend morphology, which will limit the efficiency. One of the efficient approaches is structural tuning, among which the π‐bridge engineering is considered as a good method to improve the blend morphology. Herein, we synthesized two porphyrin‐based small‐molecule donors, Por‐BR and Por‐TR, by introducing alkoxybenzene and alkylthiophene as π bridges. The Por‐BR‐based active layer produces poor morphology and does not achieve satisfying device efficiency because of the excessive aggregation tendency. As for Por‐TR, an efficiency of 11.26% is achieved with such a high open circuit voltage of 0.904 V. This study shows that altering π‐bridge units can facilitate the improvement of film morphology, finally increase the device performance, and also provides a sample for molecule designing in terms of structure‐property correlation.
Effect of palm biodiesel blends on cold start performance and emissions of common rail turbocharged engine at moderately cold ambient temperatures
Authors: Nursyairah Jalil , Lau Harrison Lik Nang , Jalal Rifqi Irzuan Abdul , Loh Soh Kheang 
Published: November 2022

AbstractPalm biodiesel fuel is limited to 7% (v/v), that is, B7 in petroleum diesel used at Malaysian highlands due to concerns over poor flow characteristics. This article investigated the cold start performance of a common rail direct injection turbocharged diesel engine using B7, B10, B20, and B30 blends in a simulated cold climatic chamber at 5, 10, 15, and 20°C. All the blends passed the startability test at 20°C but failed at 5°C. Higher biodiesel blend of B20 could withstand moderate cold temperature (15°C) without startability issue, while B7 and B10 were usable beyond 15°C. Engine workability after start‐up was insignificantly affected though, on average, 23% increase and 56% reduction observed in engine starting time and speed stability between B7 (standard) and other blends. Emissions of CO was noticeable, <0.1%, while CO2 and NOx were reduced by 13% and 18%, respectively during cold start‐up using B10 and B20. It is expected that B20 could be destined for at the Malaysian highlands with the coldest temperature not exceeding 15°C threshold for more than 5 h. Considering the importance of cold filter plugging point, it is suggested for inclusion in existing diesel standards to minimize issues while deploying high biodiesel blends at highlands commercially.
Improved N‐acetylneuraminic acid bioproduction by optimizing pathway for reducing intermediate accumulation
Authors: Guo Haoyu , Tian Rongzhen , Wang Chenyun , Zhao Runzhi , Lv Xueqin , Liu Long , Liu Yanfeng 
Published: November 2022

AbstractN‐acetylneuraminic acid (NeuAc), which has been widely used as a nutraceutical and pharmaceutical intermediate, plays an important role in improving brain development and cognition while enhancing immunity. Bacillus subtilis, generally regarded as a food‐safe microorganism, is suitable for developing as a chassis cell for efficient NeuAc synthesis. However, accumulated intermediates can lead to metabolic bottlenecks for NeuAc synthesis. To eliminate the accumulated byproduct N‐acetylglucosamine (GlcNAc), the UDP‐GlcNAc epimerase pathway without GlcNAc production was first reconstructed and optimized in B. subtilis, resulting in the NeuAc titer increase of 5.9 g/L with GlcNAc elimination. In addition, to reduce another accumulated byproduct N‐acetylmannosamine (ManNAc), the directed evolution of N‐acetylneuraminic acid synthase and the enhancement of phosphoenolpyruvate supply was implemented. Using this strategy, ManNAc decreased by 46.3%, and the NeuAc titer increased by 54.9%, reaching 7.9 g/L. Finally, the maximum titer of NeuAc in a 3‐L fermenter reached 21.8 g/L with a productivity of 0.34 g/L/h.
Why worry with friends? Problem talk and anxiety in late adolescent friendships
Authors: Herzig Kathleen A. , Stewart Catherine E. , Treadwell Kimberli R. H. 
Published: November 2022

AbstractIntroductionThis study investigated a theoretically derived peer conversation style, problem anxiety talk, to examine the emotional regulation of anxiety in dyads as a possible mechanism of anxiety contagion that occurs between adolescent friends.MethodsIn Study 1, 376 late adolescents residing in the United States, ages 17–24 with 68% female, responded to measures of anxiety, worry, friendship quality, depression, co‐rumination, and a new measure of problem anxiety talk. In Study 2 problem anxiety talk, stress, anxiety and depression were evaluated in 481 late adolescents, ages 17–24 with 64% female.ResultsOnce controlling for worry and co‐rumination, problem anxiety talk with a close friend predicted anxiety, stress and depression for both samples of late adolescents. Factor analysis in each sample supported problem anxiety talk as a single factor with high internal consistency.ConclusionsFindings indicate that problem anxiety talk is a distinct construct representing interpersonal disclosures between friends involving threat perception, likelihood of negative events, and lack of coping skills; results also indicate that problem anxiety talk is associated with anxiety, stress, worry, and depression. Implications of problem anxiety talk in its potential role in the etiology and spread of anxiety are discussed.
Surveying the Landscape of Social Media Usage for Health Care by Otolaryngology Patients
Authors: Kini Sameer D. , Houssein Firas A. , Derbarsegian Armo , Adams Sarah M. , Phillips Katie M. , Sedaghat Ahmad R. 
Published: November 2022

ObjectiveTo determine factors associated with social media usage for finding a doctor or seeking medical advice among otolaryngology patients.MethodsCross‐sectional study of 361 patients visiting our clinics. All participants were asked if they were aware social media may be used to find doctors and if they had ever done so, and also if they were aware social media could be used to get advice about a medical condition or its treatment and if they had ever done so. Demographic characteristics were examined for association with affirmative answers to these questions.ResultsFacebook was the most used social media platform with 50.7% using Facebook daily. Over 50% of participants were aware social media could be used to find a doctor or seek medical advice. Daily use of Facebook was associated with using social media for finding a doctor (OR = 2.57, 95%CI: 1.41–4.67, p = 0.002) and seeking medical advice (OR = 1.72, 95%CI: 1.09–2.71, p = 0.020). Having Medicare was associated with using social media to find a doctor (OR = 2.20, 95%CI: 1.15–4.21, p = 0.017), whereas Medicaid was associated with using social media for medical advice (OR = 1.99, 95%CI: 1.08–3.67, p = 0.027).ConclusionA majority of otolaryngology patients may be aware of health care applications of social media, with Facebook being the dominant platform, and Medicare insurance identifying patients who may most use social media in this manner. There is also an indication that social determinants of health, as reflected by Medicaid insurance, may be associated with using social media to seek medical advice.Level of EvidenceNA Laryngoscope, 133:2116–2121, 2023
Remarks on derived complete modules and complexes
Authors: Positselski Leonid 
Published: November 2022

AbstractLet R be a commutative ring and a finitely generated ideal. We discuss two definitions of derived I‐adically complete (also derived I‐torsion) complexes of R‐modules, which appear in the literature: the idealistic and the sequential ones. The two definitions are known to be equivalent for a weakly proregular ideal I; we show that they are different otherwise. We argue that the sequential approach works well, but the idealistic one needs to be reinterpreted or properly understood. We also consider I‐adically flat R‐modules.
Environmental implications of political connections and state ownership: Theory and evidence from China
Authors: Yu Haowei , Wang Ruoyu , He Ling‐Yun 
Published: November 2022

AbstractPolitical connections and state ownership have ubiquitous impacts on the economy, yet the environmental implications are largely unexplored. This paper theoretically and empirically studies the role of political connections and state ownership on the environment in China. Our theoretical analysis indicates that political connections are conducive to more pollutant emissions, and state ownership exhibits a similar direct effect. State ownership also has an indirect effect on pollutant emissions that depends on the interplay with political connections. In the case of chemical oxygen demand (COD), our empirical results show that the effect of political connections is positive, so are the direct and indirect effects of state ownership. Moreover, firm managers' political background of government officials at the county level is mainly accountable for the environmental implication of political connections. Furthermore, we find that political connections mainly affect the implementation of environmental policies, while state ownership could have similar effects on both the implementation and the making of environmental policies.
Metabolism and Recovery of Epithionitriles from Glucosinolates—A Human Intervention Study
Authors: Hoffmann Holger , Baldermann Susanne , Wiesner‐Reinhold Melanie , Bergmann Manuela M. , Grune Tilman , Hanschen Franziska S. 
Published: November 2022

ScopeEpithionitriles can be main glucosinolate hydrolysis products in Brassica vegetables such as cabbage or pak choi. Here, for the first time, the bioavailability and metabolism of longer‐chain epithionitriles (C4–C5) is studied in a human intervention study.Methods and resultsAfter consumption of a white cabbage or pak choi sprouts beverage, rich in either 1‐cyano‐2,3‐epithiopropane (CETP) or 1‐cyano‐3,4‐epithiobutane (CETB) and 1‐cyano‐4,5‐epithiopentane (CETPent), blood and urine samples of nine participants are taken and the metabolites are analyzed. The corresponding N‐acetyl‐S‐(cyano‐(methylthio)alkyl)‐l‐cysteine metabolites are identified and quantified by isotope dilution method using UHPLC‐TOF‐MS. The standards for N‐acetyl‐S‐(cyano‐(methylthio)alkyl)‐l‐cysteine metabolites from CETB and CETPent are synthesized for the first time and their structure confirmed by NMR spectroscopy. In contrast to the metabolites of CETP and CETPent, the expected metabolite of CETB is not detectable. The recoveries of the CETP and CETPent metabolites are 28 ± 9% for CETP and 12 ± 3% for CETPent in urine within 24 h.ConclusionCETP and CETPent are quickly uptaken, metabolized via the mercapturic acid pathway, and excreted via urine, while for CETB the corresponding metabolite is not detectable. Therefore, an additional metabolization pathway seems to exist.
Everyday challenges following hospital discharge. A multi‐method study identifying and describing areas of concern for patients during the first month after colorectal cancer surgery
Authors: Jakobsson Jenny , Kumlien Christine 
Published: November 2022

AbstractAimIdentify and describe areas of concern focusing on day‐to‐day variations during the first month after surgery for patients recovering from colorectal cancer surgery.DesignA multi‐method design was applied using diaries and interviews.MethodData was collected using semi‐structured diaries kept 1 month after surgery by seven patients recovering from colorectal cancer surgery. Also, face‐to‐face interviews were conducted 1 month after surgery. Data from the diaries constituted a framework for the following directed content analysis of interviews.FindingsLow levels of pain were experienced but caused reduced mobility and tiredness. Practical matters in daily living were restricted, while social life could be hampered by a frequent need to defecate. Appetite and consequently the ability to eat and drink was the most prominent concern, due to changes in taste and ability to tolerate food. Worries were mainly related to changes in bowel movements.No Patient or Public Contribution.
Numerical approximation of the optimal control of a population dynamics model
Authors: Alahyane Mohamed , Soufyane Abdelaziz , Zahri Mostafa 
Published: November 2022

AbstractIn this paper, we present a numerical approach to an inverse problem of a population dynamics model. We propose a numerical approximation of the optimal control for obtaining the desired observation state using the augmented Lagrangian method. Moreover, the existence and uniqueness of the numerical solutions are mathematically investigated in this work. Finally, we present some numerical experiments to illustrate our theoretical results.
Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells
Authors: Eymael Jennifer , van den Broek Martijn , Miesen Laura , Monge Valerie Villacorta , van den Berge Bartholomeus T , Mooren Fieke , Velez Vicky Luna , Dijkstra Jelmer , Hermsen Meyke , Bándi Péter , Vermeulen Michiel , de Wildt Saskia , Willemsen Brigith , Florquin Sandrine , Wetzels Roy , Steenbergen Eric , Kramann Rafael , Moeller Marcus , Schreuder Michiel F , Wetzels Jack FM , van der Vlag Johan , Jansen Jitske , Smeets Bart 
Published: November 2022

AbstractScattered tubular cells (STCs) are a phenotypically distinct cell population in the proximal tubule that increase in number after acute kidney injury. We aimed to characterize the human STC population. Three‐dimensional human tissue analysis revealed that STCs are preferentially located within inner bends of the tubule and are barely present in young kidney tissue (<2 years), and their number increases with age. Increased STC numbers were associated with acute tubular injury (kidney injury molecule 1) and interstitial fibrosis (alpha smooth muscle actin). Isolated CD13+CD24−CD133− proximal tubule epithelial cells (PTECs) and CD13+CD24+ and CD13+CD133+ STCs were analyzed using RNA sequencing. Transcriptome analysis revealed an upregulation of nuclear factor κB, tumor necrosis factor alpha, and inflammatory pathways in STCs, whereas metabolism, especially the tricarboxylic acid cycle and oxidative phosphorylation, was downregulated, without showing signs of cellular senescence. Using immunostaining and a publicly available single‐cell sequencing database of human kidneys, we demonstrate that STCs represent a heterogeneous population in a transient state. In conclusion, STCs are dedifferentiated PTECs showing a metabolic shift toward glycolysis, which could facilitate cellular survival after kidney injury. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Decision aid development and its acceptability among adults with attention‐deficit/hyperactivity disorders regarding treatment discontinuation after remission
Authors: Tsujii Noa , Okada Takashi , Usami Masahide , Kuwabara Hidenori , Fujita Junichi , Negoro Hideki , Iida Junzo , Aoki Yumi , Takaesu Yoshikazu , Saito Takuya 
Published: November 2022

AbstractAimCurrent clinical guidelines for attention‐deficit/hyperactivity disorder (ADHD) put shared decision making (SDM) at the center of care. However, there remain challenges in SDM in ADHD management, particularly regarding the decision to continue or discontinue medication after ADHD remission in adult patients. We aimed to develop a decision aid (DA) for adult patients with ADHD regarding the continuation or discontinuation of their ongoing ADHD medications after they have attained remission.MethodWe systematically developed a DA according to the International Patient Decision Aid Standard (IPDAS). First, we created a DA prototype using the results of our previous systematic review and meta‐analysis that identified the consequences of continuing and discontinuing ADHD medications. Second, we administered a mixed‐method questionnaire (alpha acceptability testing) to adult patients with ADHD and healthcare providers to improve the DA prototype and develop it into a final version that is acceptable for clinical settings.ResultsOur DA consisted of ADHD description, the option to continue or discontinue ADHD medications, the advantages and disadvantages of the consequences, as well as value clarification exercises for each option. Patients (n = 20) reported that the DA had acceptable language (85%), adequate information (75%), and a well‐balanced presentation (53%). Healthcare providers (n = 19) provided favorable feedback. The final DA met all six IPDAS requisite criteria.ConclusionsOur results could facilitate the SDM process between patients and healthcare providers on the continuation or discontinuation of ADHD medication following remission. Further studies should verify the effects of using the DA during the SDM process among patients across the age spectrum with ADHD and healthcare providers.