bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE EFFECT OF SPIRITUAL EMOTIONAL FREEDOM TECHNIQUE (SEFT) THERAPY METHODS ON CHANGES IN ADOLESCENT SMOKING BEHAVIOR
Authors: Winarti Rahayu , Nurkhastana Indar , Rohana Nana 
Published: August 2022

Smoking behavior in adolescents is a difficult behavior to change. In cigarettes there are addictive ingredients that make dependence on the wearer. The phenomenon obtained in Bendungan Village, there are 42 teenagers aged 15-19 years who have smoking behavior due to invitations from friends, curiosity, often seeing parents smoking and the desire of teenagers themselves. The Spiritual Emotional Freedom Technique (SEFT) method by tapping 2 fingers on 18 key points in the body's 12 energy pathways. The purpose of this study was to determine the effect of the SEFT therapy method on changes in smoking behavior in adolescents in Bendungan Village, Pabelan District, Semarang Regency.
The research design used is a quantitative method using a pre-experimental type with a one group pretest-posttest design. The sampling technique used 30 respondents. The research instrument is a questionnaire that has been tested for validity in research (Anggraeni, 2019) with the title "Peer Peer Relationships with Smoking Behavior in Early Adolescents" the number of respondents in this assessment is 15 people with an r value of 0.518 provided that the value of r product moment > r table (0.514), then it is declared valid. The analytical method used is Paired Sample T-test.
The results showed that smoking behavior before SEFT therapy was in the moderate category (86.7%) than after being given SEFT therapy in the good category (63.3%). The results of the analysis with the Paired Sample T-test test obtained p value = 0.000 means p value
The Comparison of Mungbean (vigna radiata L.) Cultivars in the Presence of Various Potassium Applications
Authors: Ali Umed , Shar Tahmina , Jatoi Ghulam Hussain , Shah Syed Mushtaq Ahmed , Shah Liaqat , Ahmed Irfan , Qambrani Jahansher , Bhutto Mahpara Khatoon , Haskheli Naeema Khatoon 
Published: August 2022

Potassium (K) comes under a category of major plant nutrients and is essentially required for plant to complete its life cycle. It is involved in promoting the growth yield and quality of most crops. There are confusions regarding applying accurate potassium dose and investigating the performance of two mungbean cultivars under potassium applications, an experimental trial was laid down at the research area of Pulse Research Sub-Station, Tandojam to determine the performance of two mungbean (AEM-96 and C-23) cultivars in the presence of five potassium applications i.e., 00, 20, 30, 40, and 50 kg K ha-1. The outcomes from the study showed that each trait was significantly improved by increasing the applications of potassium. A significant (P≤0.05) improvement in the growth parameters (Plant height and branches per plant), yield attributes (pods per plant, seeds per pod, seed weight per plant and 1000-seed weight) and yield traits (seed yield and biological yield) was observed in both cultivars under the application of 50 kg K ha-1. While both cultivars showed similar lower performance in accordance with control (00 kg K ha-1) plots. From cultivars, AEM-96 produced best results as compared to C-23 for each trait on each potassium level. In this regard, mungbean cultivar AEM-96 with 50 kg K ha-1 was recommended for cultivation to obtain good growth and yield performance.
Estrategias de afrontamiento en pacientes con cáncer
Authors: Cruz Lucero Verónica Cristina , Echeverría Villacreses Wilson Oswaldo 
Published: August 2022

Introducción: El diagnóstico de cáncer genera una inestabilidad emocional y en muchos casos esto imposibilita un afrontamiento adecuado. El afrontamiento es el esfuerzo cognitivo y conductual constantemente cambiantes que se desarrollan para manejar las demandas específicas como el diangóstico oncológico. El objetivo de la presente investigación fue identificar las estrategias de afrontamiento en un grupo de pacientes con cáncer, en un Hospital de referencia nacional.
Metodología: Este estudio transversal, se realizó en el Hospital Eugenio Espejo de Quito, Ecuador, período enero a junio del 2018, con una muestra no probabilística, de pacientes con neoplasias, se registraron variables demográficas, clínicas, y el test de afrontamiento de 40 preguntas CSI “El inventario de estrategias de afrontamiento (CSI). Se utiliza estadística descriptiva univariada.y bivariada.
Resultados: Se analizan 47 casos, 74% mujeres, de edad promedio 55 años. De instrucción secundaria completa en el 38 % de los casos. Las Estrategias de Afrontamiento que se presentaron en el 70% de los pacientes fueron: Reestructuración Cognitiva (REC) y Evitación de problemas (EVP), en el 15% se presentó "Resolución de problemas" (REP). Las Estrategias de Afrontamiento en hombres fueron REP con el 57%, mientras que la Expresión Emocional (EEM) se presentó en mujeres en el 86%. En los primeros 6 meses el 77% usa la EEM; de 7 a 12 meses el 19% a la estrategia de Autocrítica (AUC); de 1 a 2 años con un 17% estrategia de Pensamiento Desiderativo (PSD); de 3 o más años con un 14% corresponde a Resolución de Problemas (REP).
Conclusión: Las estrategias de afrontamiento se utilizan en gran proporción en los primeros 6 meses del diagnóstico del cáncer, luego de lo cual las estrategias disminuyen por debajo del 20%.
A Systematic Review of Fall Risk Factors in Stroke Survivors: Towards Improved Assessment Platforms and Protocols
Authors: Abdollahi Masoud , Whitton Natalie , Zand Ramin , Dombovy Mary , Parnianpour Mohamad , Khalaf Kinda , Rashedi Ehsan 
Published: August 2022

Background/Purpose: To prevent falling, a common incident with debilitating health consequences among stroke survivors, it is important to identify significant fall risk factors (FRFs) towards developing and implementing predictive and preventive strategies and guidelines. This review provides a systematic approach for identifying the relevant FRFs and shedding light on future directions of research.Methods: A systematic search was conducted in 5 popular research databases. Studies investigating the FRFs in the stroke community were evaluated to identify the commonality and trend of FRFs in the relevant literature.Results: twenty-seven relevant articles were reviewed and analyzed spanning the years 1995–2020. The results confirmed that the most common FRFs were age (21/27, i.e., considered in 21 out of 27 studies), gender (21/27), motion-related measures (19/27), motor function/impairment (17/27), balance-related measures (16/27), and cognitive impairment (11/27). Among these factors, motion-related measures had the highest rate of significance (i.e., 84% or 16/19). Due to the high commonality of balance/motion-related measures, we further analyzed these factors. We identified a trend reflecting that subjective tools are increasingly being replaced by simple objective measures (e.g., 10-m walk), and most recently by quantitative measures based on detailed motion analysis.Conclusion: There remains a gap for a standardized systematic approach for selecting relevant FRFs in stroke fall risk literature. This study provides an evidence-based methodology to identify the relevant risk factors, as well as their commonalities and trends. Three significant areas for future research on post stroke fall risk assessment have been identified: 1) further exploration the efficacy of quantitative detailed motion analysis; 2) implementation of inertial measurement units as a cost-effective and accessible tool in clinics and beyond; and 3) investigation of the capability of cognitive-motor dual-task paradigms and their association with FRFs.
Vitamin D and curcumin-loaded PCL nanofibrous for engineering osteogenesis and immunomodulatory scaffold
Authors: Al-Bishari Abdullrahman M. , Al-Shaaobi Bilal A. , Al-Bishari Aisha A. , Al-Baadani Mohammed A. , Yu Liang , Shen Jiating , Cai Lei , Shen Yiding , Deng Zhennan , Gao Peng 
Published: August 2022

The accelerating bone healing process is still a major challenge in clinical orthopedics, especially in critical-sized bone defects. Recently, Nanofiber membranes are showing increasing attention in the biomedical field due to their good biocompatibility, mechanical stability, and the ability to work as a drug carrier to achieve localized and sustained drug delivery. Herein, a multifunction nanofiber membrane loaded with vitamin D (Vit D) and curcumin (Cur) was successfully fabricated using electrospinning technology. In addition, we innovatively modified Vit D with PEG to improve the hydrophilicity of PCL nanofibers. The vitro results of CCK-8, alkaline phosphatase (ALP) and mineralization demonstrated that the PCL/Vit D-Cur membrane had great potential for enhancing the proliferation/differentiation of osteoblasts. Moreover, the synergistic effect of Vit D-Cur loaded PCL nanofiber membrane showed a superior ability to improve the anti-inflammatory activity through M2 polarization. Furthermore, in vivo results confirmed that the defect treated with PCL/Vit D-Cur nanofiber membrane was filled with the newly formed bone after 1 month. These results indicate that the Vit D/Cur loaded membrane can be applied for potential bone regeneration therapy.
A reagentless electrochemical immunosensor for sensitive detection of carcinoembryonic antigen based on the interface with redox probe-modified electron transfer wires and effectively immobilized antibody
Authors: Zhang Jing , Yang Luoxing , Pei Jie , Tian Yanzhang , Liu Jiyang 
Published: August 2022

Convenient and sensitive detection of tumors marked in serum samples is of great significance for the early diagnosis of cancers. Facile fabrication of reagentless electrochemical immunosensor with efficient sensing interface and high sensitivity is still a challenge. Herein, an electrochemical immunosensor was easily fabricated based on the easy fabrication of immunoassay interface with electron transfer wires, confined redox probes, and conveniently immobilized antibodies, which can achieve sensitive and reagentless determination of the tumor marker, carcinoembryonic antigen (CEA). Carboxyl multi-walled carbon nanotubes (MWCNTs) were firstly modified with an electrochemical redox probe, methylene blue (MB), which has redox potentials distinguished from those of redox molecules commonly existing in biological samples (for example, ascorbic acid and uric acid). After the as-prepared MB-modified MWCNT (MWCNT-MB) was coated on the supporting glassy carbon electrode (GCE), the MWCNT-MB/GCE exhibited improved active area and electron transfer property. Polydopamine (PDA) was then in situ synthesized through simple self-polymerization of dopamine, which acts as the bio-linker to covalently immobilize the anti-CEA antibody (Ab). The developed immunosensor could be applied for electrochemical detection of CEA based on the decrease in the redox signal of MB after specific binding of CEA and immobilized Ab. The fabricated immunosensor can achieve sensitive determination of CEA ranging from 10 pg/ml to 100 ng/ml with a limit of detection (LOD) of 0.6 pg/ml. Determination of CEA in human serum samples was also realized with high accuracy.
Micro-Scale Pore-Throat Heterogeneity of Tight Oil Sandstone Reservoirs and Its Influence on Fluid Occurrence State
Authors: Guo Qing , Dong Mancang , Mao Hengbo , Ju Jiangtao 
Published: August 2022

Quantitatively characterizing the micro-scale heterogeneity of pore throats in tight sandstone reservoirs is the key to accurately describing the influence of pore structures on fluid occurrence characteristics. In this study, taking the Chang 6 Member of the Yanchang Formation in the Huaqing area of the Ordos Basin as an example, the pore-throat heterogeneity of tight sandstone reservoirs and its influence on the fluid occurrence state have been systematically studied using cast thin section, scanning electron microscope, X-ray diffraction, constant velocity mercury intrusion, and nuclear magnetic resonance tests. The main types of pores developed in the target layer were intergranular pores, followed by feldspar dissolution pores. The radius distribution of the intergranular pores is between 5.0 and 210 μm, with an average value of 50.27 μm. In addition, the pore combination types with the best petrophysical properties are the intergranular pore type, the intergranular-dissolution pore type, and the dissolution-intergranular pore type; the average permeability and porosity are 0.62 mD, 0.40 mD, 0.44 mD, and 12.0, 12.3, 12.3%, respectively. The target sandstones contain four typical T2 relaxation time types. The large-pore-fine-throat combination reservoir has the best petrophysical properties. The larger the pore-throat uniformity value, the more uniform the pore-throat radius, and the greater the reservoir permeability. Therefore, the uniformity of throat development controls the seepage capacity of the tight reservoirs. The movable fluid saturation of different pore types has obvious differences. The movable fluid saturations at the 0.1 and 0.5 μm pore diameters of the macro-pore-fine-throat and macro-pore-micro-throat reservoirs both show an obvious inflection point, and the movable water saturation is higher with a larger throat radius.
Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing’s disease in remission
Authors: Pupier Emilie , Santos Alicia , Etchamendy Nicole , Lavielle Aurélie , Ferriere Amandine , Marighetto Aline , Resmini Eugenia , Cota Daniela , Webb Susan M. , Tabarin Antoine 
Published: August 2022

ContextImpaired cognition and altered quality of life (QoL) may persist despite long-term remission of Cushing’s disease (CD). Persistent comorbidities and treatment modalities may account for cognitive impairments. Therefore, the role of hypercortisolism per se on cognitive sequelae remains debatable.ObjectiveTo investigate whether memory and QoL are impaired after long-term remission of CD in patients with no confounding comorbidity.Design and SettingCross-sectional case-control study in two tertiary referral centersPatients25 patients (44.5 ± 2.4 years) in remission from CD for 102.7 ± 19.3 Mo and 25 well-matched controls, without comorbidity or treatment liable to impair cognition.Main Outcome Measure(s)Hippocampus- and prefrontal cortex-dependent memory, including memory flexibility and working memory, were investigated using multiple tests including sensitive locally-developed computerized tasks. Depression and anxiety were evaluated with the MADRS and HADS questionnaires. QoL was evaluated with the SF-36 and CushingQoL questionnaires. The intensity of CD was assessed using mean urinary free cortisol and a score for clinical symptoms.ResultsCD patients displayed similar performance to controls in all cognitive tests. In contrast, despite the absence of depression and a minimal residual clinical Cushing score, patients had worse QoL. Most of the SF36 subscales and the CushingQoL score were negatively associated only with the duration of exposure to hypercortisolism (p≤ 0.01 to 0.001).ConclusionsPersistent comorbidities can be a primary cause of long-lasting cognitive impairment and should be actively treated. Persistently altered QoL may reflect irreversible effects of hypercortisolism, highlighting the need to reduce its duration.Clinical Trial Registration numberhttps://clinicaltrials.gov, identifier NCT02603653
Synergetic use of unmanned aerial vehicle and satellite images for detecting non-native tree species: An insight into Acacia saligna invasion in the Mediterranean coast
Authors: Marzialetti Flavio , Di Febbraro Mirko , Frate Ludovico , De Simone Walter , Acosta Alicia Teresa Rosario , Carranza Maria Laura 
Published: August 2022

Invasive alien plants (IAPs) are increasingly threatening biodiversity worldwide; thus, early detection and monitoring tools are needed. Here, we explored the potential of unmanned aerial vehicle (UAV) images in providing intermediate reference data which are able to link IAP field occurrence and satellite information. Specifically, we used very high spatial resolution (VHR) UAV maps of A. saligna as calibration data for satellite-based predictions of its spread in the Mediterranean coastal dunes. Based on two satellite platforms (PlanetScope and Sentinel-2), we developed and tested a dedicated procedure to predict A. saligna spread organized in four steps: 1) setting of calibration data for satellite-based predictions, by aggregating UAV-based VHR IAP maps to satellite spatial resolution (3 and 10 m); 2) selection of monthly multispectral (blue, green, red, and near infra-red bands) cloud-free images for both satellite platforms; 3) calculation of monthly spectral variables depicting leaf and plant characteristics, canopy biomass, soil features, surface water and hue, intensity, and saturation values; 4) prediction of A. saligna distribution and identification of the most important spectral variables discriminating IAP occurrence using a fandom forest (RF) model. RF models calibrated for both satellite platforms showed high predictive performances (R2 &gt; 0.6; RMSE &lt;0.008), with accurate spatially explicit predictions of the invaded areas. While Sentinel-2 performed slightly better, the PlanetScope-based model effectively delineated invaded area edges and small patches. The summer leaf chlorophyll content followed by soil spectral variables was regarded as the most important variables discriminating A. saligna patches from native vegetation. Such variables depicted the characteristic IAP phenology and typically altered leaf litter and soil organic matter of invaded patches. Overall, we presented new evidence of the importance of VHR UAV data to fill the gap between field observation of A. saligna and satellite data, offering new tools for detecting and monitoring non-native tree spread in a cost-effective and timely manner.
Identification of CXCL10 and CXCL11 as the candidate genes involving the development of colitis-associated colorectal cancer
Authors: Lu Can , Zhang Xiaopeng , Luo Yang , Huang Jingang , Yu Minhao 
Published: August 2022

Background: Ulcerative colitis (UC) is a well-known risk factor for developing colitis-associated colorectal cancer (CAC). However, the molecular mechanism of the pathogenesis of CAC remains unclear. This study aimed to explore candidate genes involved in the tumorigenesis of CAC.Methods: GSE75214 and the Cancer Genome Atlas Program (TCGA) dataset were used to analyze the differentially expressed genes (DEGs) in UC and colorectal cancer (CRC), respectively. Survival-hub genes were identified from these DEGs by sequentially constructing a protein–protein interaction network, selecting hub genes, and conducting survival analysis. Regulatory signatures were also predicted on these genes through the online database. Apcmin/+ and UC mice models were used to validate the expression of the above-predicted molecules. Gene set enrichment analysis and CIBERSORT were performed to explore the enriched molecular pathways and associated tissue-infiltrating immune cells of genes.Results: Here, 376 common DEGs were identified from the GSE75214 and TCGA datasets. Through survival-hub gene selection and in vivo experiments, we confirmed that CXCL10 and CXCL11 were significantly upregulated in UC and CRC. We also proved that miR-34a-5p and miR-203a-5p were potential regulators of CXCL10 and CXCL11. Meanwhile, CXCL10 and CXCL11 may activate the JAK–STAT signaling pathway via the interaction with cytokine receptors in UC. Furthermore, CXCL10 and CXCL11 were positively associated with the tissue infiltration of proinflammatory M1 macrophages in UC and CRC.Conclusion: CXCL10 and CXCL11 may act as the candidate genes involved in the tumorigenesis of CAC and potential therapeutic targets to prevent the development of CAC from UC.
Association between sleep-disordered breathing and periodontal diseases: A systematic review protocol
Authors: Chen Danyan , Meng Ziyan , Zhao Tingting , Yu Xueqian , He Hong , Hua Fang , Dong Weili 
Published: August 2022

BackgroundSleep-disordered breathing (SDB) is a chronic sleep-related breathing disorder, considered associated with increased risk of cardiovascular disorders, metabolic disorders, cognitive dysfunction and behavior changes. Periodontal diseases are chronic infectious diseases that are also believed to be associated with cardiovascular diseases, metabolic syndrome and cognitive dysfunction. Several studies have indicated that SDB may be associated with periodontal diseases through certain mechanisms such as inflammation response, oxidative stress and oral dryness. The aim of this systematic review is to explore the association between SDB and periodontal diseases in an integrated approach.Materials and MethodsThis systematic review will include cohort studies, cross-sectional studies and case-control studies that are identified by electronic and manual searches. Electronic searches will be conducted in the following databases: PubMed, Embase, Scopus and Web of Science. Our search will cover articles published from inception of databases to March 2022 without restrictions in language and settings. Pre-determined eligibility criteria include: participants (participants without a history of respiratory diseases, history of periodontal treatment within the past 6 months and history of medication that is known to influence SDB or periodontal diseases); exposure (participants who have been diagnosed with SDB or at high-risk for SDB); comparison (participants without SDB); and outcome (periodontal parameters, such as probing depth, clinical attachment level, bleeding on probing, radiographic bone loss). Two authors will perform study screening and data extraction independently and in duplicate. All discrepancies will be solved by discussion. The methodological quality of included studies will be assessed using the Newcastle-Ottawa Scale.DiscussionThis systematic review will summarize the existing evidence on the association between SDB and periodontal diseases, a topic of controversy and clinical significance. Its findings can provide evidence for the development of relevant prevention and treatment strategies. The results will be disseminated through peer-reviewed journals.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022313024. Registered on March 28th 2022.