bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal and age dynamics of rabbits infestation with spirochetosis in the southern and northern regions of Ukraine
Authors: Duda Yu. V. , Koreyba L. V. 
Published: February 2022

In the age and seasonal aspect, the peak of spirochetosis infection is observed in rabbits aged 3–4 months in the autumn. A significant increase in the extent and intensity of damage to rabbits by the pathogen spirochetosis was registered from July to October with a peak in September (EI = 69.81 %, II = 1080.19 ± 83.40 pathogens per 1 g of feces). The average infestation of rabbits by pathogen Treponema cuniculi was 24.82 %. The largest number of sick animals was registered in the Cherkasy region. The goal of the work: determining the influence of age and seasons on the dynamics of the disease of spirochetosis of rabbits of the Californian breed of yard maintenance in different natural and climatic zones. The work was carried out during 2014–2020 in the conditions of a private enterprise for breeding rabbits of the Californian breed, which used cage keeping of animals without air conditioning in compliance with all zoohygienic requirements. Darkfield microscopy was used to detect Treponema cuniculi. The obtained results and calculated averages for animal age and seasons were counted using Microsoft Excel-16. The results of parasitological studies indicate that spirochetosis in rabbits is registered during the year, but the maximum incidence of animals was established in the summer-autumn period of the year, when EI reached 39.92 % and 46.15 %, for II 423.57 ± 52.50 ekz./g and 628.21 ± 50.86 ekz./g. In winter, the rates of animal infestation reached the minimum values (EI = 8.17 %, II = 12.74 ± 2.96), and with the onset of spring rose again (EI = 13.64%, II = 22.73 ± 3.93), in the summer the rise continued (EI = 39.92%, II = 423.57 ± 52.50), reaching a maximum in autumn (EI = 46.15 %, II = 628.21 ± 50.86). A significant increase in the extent of damage to rabbits by the causative agent of spirochetosis was registered from July to October with a peak in September (EI = 69.81 %). In November, the infestation decreased sharply and remained low in winter until mid-spring, with the lowest value observed in February (6.86 %). The peak level of spirochetes in rabbits was registered in September and was equal to 1080.19 ± 83.40 pathogens in 1 g of feces, and a decrease in the biopotential of parasites is observed in February (II = 9.80 ± 4.06 pathogens in 1 g of feces). It was found that the invasiveness of Treponema cuniculi rabbits increases with age from 2–4 months of age (EI from 88.23 % to 88.89 %, with the intensity of the lesion from 794.11 ± 108.62 to 1688.89 ± 253.01 pathogens in 1 g of feces. From 5 months of age to 1–2 years, the rates of infection are gradually reduced: EI to 82.75 %, with the intensity of the lesion to 924.14 ± 109.26 pathogens in 1 g of feces. During the studying period, rabbits of private households located in the Forest-Steppe zone were found. Rabbits of private households, which were located in the Forest-Steppe zone, were the most unfavourable for spirochetosis during the study period.
Modelo de gestión inclusivo para la atención a los alumnos con déficit visual de cuarto grado de la Institución Nicolás Infante Díaz
Authors: Bustamante-Montoya Paola , Zambrano-Giler Maria , Prieto-López Yeimer 
Published: February 2022

La investigación logra detectar la causa del rendimiento académico de los estudiantes de cuarto grado de educación general básica de la institución, situación que se ha dado por el déficit de visión. Se realizó el diagnóstico y se pudo evidenciar la dificultad en el aprendizaje, razón por la cual estas complicaciones visuales, repercuten negativamente en el rendimiento escolar. Es importante, que las instituciones brinden apoyo incondicional a los estudiantes con dificultades educativas y se empoderen en hacer énfasis a la inclusión social de los estudiantes que tienen diferentes problemas de aprendizaje. Se aplicó la investigación descriptiva directa, dando como resultado un modelo de gestión inclusiva aplicable a cualquier necesidad educativa especial con déficit visual que se presente en la institución educativa. Dentro del proceso investigativo se tomó la guía de observación aplicada a los estudiantes de cuarto grado y una encuesta a los docentes. El diagnóstico ha permitido obtener resultados del déficit visual en los estudiantes, según el modelo de gestión inclusivo que se ha aplicado es para que los docentes fortalezcan la inclusión y la atención a los estudiantes con déficit visual. La estrategia desarrollada y el análisis obtenido han sido para motivar la vinculación e identificar las deficiencias del aprendizaje en los estudiantes.
Incidencia del clima laboral en el desempeño docente de la carrera de Licenciatura en Educación Básica en la Universidad de las Fuerzas Armadas – ESPE
Authors: Quintanilla-Ayala Leonardo , Quintanilla-Aldeán Carlos , Prieto-López Yeimer 
Published: February 2022

La característica principal de cualquier organización, incluyendo las instituciones educativas es la del trabajo en equipo de muchas personas que poseen habilidades, destrezas, experiencia y personalidad diferente, en este sentido, es imprescindible tomar en cuenta que el clima laboral es un factor fundamental para el correcto funcionamiento de la institución y el consecuente alcance de los objetivos planteados.
En la presente investigación se estableció la conexión que existe entre el clima organizacional percibido por los docentes de la carrera en Educación Básica en la Universidad de las Fuerzas Armadas – ESPE y el desempeño de sus funciones laborales. Todo esto se enmarca en el principio de que el docente es el colaborador que está directamente relacionado con el estudiante y es quien transmite los aprendizajes que requiere el mismo y no menos importante, el docente es el principal colaborador que comunica la filosofía, valores y principios de la institución no solo verbalmente sino a través de su actuar en su desempeño profesional. Este último punto va mucho más allá del conocimiento del docente en cuanto a su área, tiene que ver con la satisfacción que siente al prestar sus servicios en una organización donde siente bienestar general en todo sentido motivándolo a obtener cada vez mejores resultados en su quehacer educativo.
La investigación se basó en una metodología de corte mixto, combinando metodologías de tipo descriptiva y correlacional, además de metodologías de clase hipotético – deductivo e inductivo – deductivo, donde existe un universo de 84 docentes, los cuales participaron en su totalidad en la aplicación de una encuesta de percepción del Clima Laboral, que entre otros aspectos, toma en cuenta las dimensiones de la organización, comunicación y trabajo colaborativo, es importante mencionar también el diseño y aplicación de una entrevista a expertos que aportaron con valiosas reflexiones sobre el tema de investigación.
Púrpura trombocitopênica idiopática em crianças: uma revisão narrativa
Authors: Queiroz Márilsi das Dores , Souza Ariele Assunção Ramos de , Rocha Aline Cristina Araújo Alcântara , Santos Maria das Dores dos , Almeida Danyella Rodrigues de 
Published: February 2022

A Púrpura Trombocitopênica Idiopática é caracterizada pela diminuição do número de plaquetas circulantes, considerada autoimune e beningna, podendo ser classificada de acordo com o diagnóstico, idade e duração da doença. Objetivou-se realizar revisão da literateratura cientifica sobre a ocorrencia da pupura trombocotopênica idiopática em crianças e as possiveis intervenções de enfermagem. Trata-se de um estudo qualitativo de revisão narrativa de carater exploratório realizado em diferentes bases de dados eletrônicas. Analisou-se que as pesquisas sobre a doença existe questões controversas sobre o diagnóstico, tratamento e acompanhamento adequado para os portadores da patologia. Desta forma é necessario que mais estudo sejam realizados com maior profundidade sobre acerca do assunto, pensando no tratamento e no aumento da expectativa de vida dos portadores dessa doença.
Perfil e intervenção fisioterapêutica dos pacientes vítimas de trauma admitidos na unidade de urgência e emergência em um Hospital Universitário do Oeste do Paraná
Authors: Bavaresco Alana Caroline , Genske Juliana Hering , Branco Carla Lautenschleger , Almeida Caio Fernandes de 
Published: February 2022

Objetivos: Caracterizar o perfil das vítimas de traumas internados na sala de emergência de um Hospital Universitário do Oeste do Paraná e fazer o levantamento dos casos de trauma atendidos pelo serviço de fisioterapia, bem como as principais abordagens e condutas prestadas. Metodologia: Pesquisa observacional, retrospectiva, transversal e de caráter quantitativo, realizada através das informações dos prontuários. A amostra foi coletada através de levantamento dos pacientes que deram entrada na sala de emergência, totalizando 1.020 prontuários. A coleta de dados foi realizada no período de um ano. A análise foi realizada através de estatística descritiva simples. Resultados: Foram analisados os 1.020 prontuários, onde 17 foram excluídos por não serem efetivamente admitidos na sala de emergência. A amostra total do trabalho foi 297 prontuários, no qual a maioria é do sexo masculino com idade média de 40,26 ± 17,48 anos. A principal causa de internação dos politraumas foi devido a traumatismo cranioencefálico. 185 pacientes necessitaram de ventilação mecânica invasiva. Quanto ao desfecho final dos pacientes, somente 55 foram a óbito. Receberam atendimento fisioterapêutico 254 pacientes. Conclusão: Os principais casos de pacientes politraumatizados foram do sexo masculino, com maior prevalência no diagnóstico de Trauma Cranioencefálico, seja isolado ou associado a outros traumas. Quanto ao desfecho final, maioria teve uma evolução satisfatória, indo de alta hospitalar. Em relação a fisioterapia, pelo número elevado de pacientes politraumatizados com necessidade de ventilação mecânica, destaca-se condutas com ênfase na fisioterapia respiratória.
Humanization of care: challenges after Covid-19 pandemic
Authors: Dias Danilo Rocha , Lages Frederico Santos , Vilaça Ênio Lacerda , Diniz Ivana Márcia Alves , Castilho Lia Silva de 
Published: February 2022

Face of impacting changes in healthcare after COVID-19 pandemic, an imminent discussion is how to achieve humanization of care with so many safety barriers between healthcare providers and patients. The objective of this study is to propose an operational model to assist in the planning of actions and inspire work fronts in the fight against the Covid-19 pandemic, providing insights for future research and health policies. A search was carried out in PubMed Central using the terms “health care models” and “humanization of care”. Studies that presented conceptual and methodological aspects of health care models were selected, in addition to experience reports and systematic reviews. From the identification of critical elements for the humanization of care, an operational model was developed suggesting the most relevant themes that require solutions and organized actions to face the Covid-19 pandemic and its consequences. The proposed themes were transdisciplinary approach, health technology, cost-effectiveness, equity, social justice, education, health promotion, information access, safety and well-being, resources distribution, sustainability. This model may be useful to organize healthcare actions based on humanization of care, involving society in a collective effort to maintain the quality of care.
Three-Dimensional Innate Mobility of the Human Foot on Coronally-Wedged Surfaces Using a Biplane X-Ray Fluoroscopy
Authors: Negishi Takuo , Nozaki Shuhei , Ito Kohta , Seki Hiroyuki , Hosoda Koh , Nagura Takeo , Imanishi Nobuaki , Jinzaki Masahiro , Ogihara Naomichi 
Published: February 2022

Improving our understanding on how the foot and ankle joints kinematically adapt to coronally wedged surfaces is important for clarifying the pathogenetic mechanism and possible interventions for the treatment and prevention of foot and lower leg injuries. It is also crucial to interpret the basic biomechanics and functions of the human foot that evolved as an adaptation to obligatory bipedal locomotion. Therefore, we investigated the three-dimensional (3D) bone kinematics of human cadaver feet on level (0°, LS), medially wedged (−10°, MWS), and laterally wedged (+10°, LWS) surfaces under axial loading using a biplanar X-ray fluoroscopy system. Five healthy cadaver feet were axially loaded up to 60 kg (588N) and biplanar fluoroscopic images of the foot and ankle were acquired during axial loading. For the 3D visualization and quantification of detailed foot bony movements, a model-based registration method was employed. The results indicated that the human foot was more largely deformed from the natural posture when the foot was placed on the MWS than on the LWS. During the process of human evolution, the human foot may have retained the ability to more flexibly invert as in African apes to better conform to MWS, possibly because this ability was more adaptive even for terrestrial locomotion on uneven terrains. Moreover, the talus and tibia were externally rotated when the foot was placed on the MWS due to the inversion of the calcaneus, and they were internally rotated when the foot was placed on the LWS due to the eversion of the calcaneus, owing to the structurally embedded mobility of the human talocalcaneal joint. Deformation of the foot during axial loading was relatively smaller on the MWS due to restricted eversion of the calcaneus. The present study provided new insights about kinematic adaptation of the human foot to coronally wedged surfaces that is inherently embedded and prescribed in its anatomical structure. Such detailed descriptions may increase our understanding of the pathogenetic mechanism and possible interventions for the treatment and prevention of foot and lower leg injuries, as well as the evolution of the human foot.
Characteristics of Helicobacter pylori Heteroresistance in Gastric Biopsies and Its Clinical Relevance
Authors: Wang You-hua , Gong Xiao-ling , Liu Ding-wei , Zeng Rong , Zhou Lin-fu , Sun Xiao-yan , Liu Dong-sheng , Xie Yong 
Published: February 2022

BackgroundAntimicrobial susceptibility testing (AST) plays a vital role in anti-Helicobacter pylori treatment, but the traditional AST method has difficulty detecting heteroresistance, which may cause an increased prevalence of resistant strains and eradication failure.AimsTo investigate the characteristics of heteroresistance in H. pylori in gastric biopsies and investigate its clinical relevance.MethodA total of 704 gastric biopsies were selected for 23S rRNA and gyrA gene sequencing, 470 H. pylori isolates from these biopsies were selected for AST, and the clinical characteristics of the patients were reviewed.ResultFor the 699 biopsies that were positive for 23S rRNA gene, 98 (14.0%) showed a heteroresistance genotype, and a wild type (WT) combined with A2143G (86.7%) genotype was found in most samples. For the 694 biopsies that were positive for gyrA gene, 99 (14.3%) showed a heteroresistance genotype, and a WT combined with 87K (26.3%) or WT combined with 91N (23.2%) genotype was predominant. According to the E-test results, the resistance rates of heteroresistance genotype samples for clarithromycin and levofloxacin were 36.2% and 68.1%, respectively. When dividing the heteroresistance samples into different groups according to the sequencing profile peaks of the mutation position, the resistance rates were higher along with mutation peaks at the mutation position. In addition, patients infected with mutated or heteroresistant strains showed lower peptic ulcer detection rates than those infected with the WT strain (p &lt; 0.05).ConclusionHeteroresistance genotypes for clarithromycin and levofloxacin were not rare in H. pylori. Most cases with a heteroresistance genotype showed a susceptible phenotype for clarithromycin and a resistance phenotype for levofloxacin. Patients infected with heteroresistance genotype strains showed a lower peptic ulcer detection rate than those infected with the WT strain.
High Plasma Concentration of Apolipoprotein C-III Confers an Increased Risk of Cerebral Ischemic Events on Cardiovascular Patients Anticoagulated With Warfarin
Authors: Olivieri Oliviero , Turcato Gianni , Cappellari Manuel , Stefanoni Filippo , Osti Nicola , Pizzolo Francesca , Friso Simonetta , Bassi Antonella , Castagna Annalisa , Martinelli Nicola 
Published: February 2022

IntroductionApolipoprotein C-III (Apo CIII) is a crucial regulator of triglyceride-rich lipoproteins (TRLs) and influences the risk of cardiovascular diseases. High levels of Apo CIII have been also associated with cerebrovascular events and earlier works showed procoagulant effects of Apo CIII. The main aim was to assess whether the plasma concentration of Apo CIII could confer an increased risk of cerebral ischemic events in anticoagulated patients at high-risk of cardioembolism.MethodsWe systematically checked medical records and quantified cerebral ischemic events in a selected cohort of 118 subjects [median age 68 with interquartile range (IQR) 59–75 years, 66.9% males, 52.5% with coronary artery disease (CAD)], taking anticoagulant therapy with warfarin because of atrial fibrillation (AF) and/or mechanical prosthetic heart valves. All the subjects, enrolled between May 1999 and December 2006, were prospectively followed until death or July 31, 2018. Assessments of complete plasma lipid and apolipoprotein profiles, including Apo A-I, B, CIII, and E, were available for all subjects at enrollment.ResultsAfter a median follow-up of 109 months (IQR, 58–187), 24 subjects (20.3%) had cerebral ischemic events: stroke (n = 15) and TIA (n = 9). Subjects with plasma concentration of Apo CIII above the median value (10.3 mg/dL) had an about three-fold increased risk of stroke/TIA than those with lower levels of Apo C-III [hazard ratio 3.08 (95%CI, 1.22–7.77)]. This result was confirmed in multiple Cox regression models adjusted for gender, age, CAD, AF, diabetes, hypertension, plasma lipids, and CHA2DS2-VASc score. By stratifying the sample on the basis of Apo CIII level and CHA2DS2-VASc score, an additive effect was observed with the highest risk in subjects with both high Apo C-III concentration and CHA2DS2-VASc score.ConclusionHigh Apo CIII plasma levels may be associated with an increased risk of ischemic stroke/TIA in high-risk cardiovascular patients anticoagulated with warfarin.
Impact of Physical Activity on All-Cause Mortality According to Specific Cardiovascular Disease
Authors: Kim Moon-Hyun , Sung Jung-Hoon , Jin Moo-Nyun , Jang Eunsun , Yu Hee Tae , Kim Tae-Hoon , Pak Hui-Nam , Lee Moon-Hyoung , Lip Gregory Y. H. , Yang Pil-Sung , Joung Boyoung 
Published: February 2022

BackgroundPatients with cardiovascular disease (CVD) tend to have higher mortality rates and reduced physical activity (PA). We aimed to evaluate the effect of PA on mortality in older adults with specific CVD.MethodsWe enrolled 68,223 participants (n = 23,871 with CVD, n = 44,352 without CVD) aged ≥65 years with available physical activity data between 2005 and 2012 from the Korean National Health Insurance Service of Korea-Senior database. CVD was defined as a history of ischemic stroke, transient ischemic attack, heart failure, myocardial infarction, and peripheral artery disease.ResultsPatients with CVD were older than those without CVD. Compared with the sedentary group, the physically active groups with and without CVD had a lower incidence and risk of all-cause death during a median follow up period of 42 (interquartile range 30–51) months. A 500 metabolic equivalent task-min/week increase in PA resulted in an 11% and 16% reduction in the risk of mortality in the non-CVD and CVD groups, respectively. With regard to specific CVDs, the risk of mortality progressively reduced with increasing PA in patients with heart failure or myocardial infarction. However, the reduction reached a plateau in patients with stroke or peripheral artery disease, but was significantly greater in patients with stroke (20% vs. without stoke, 11%, Pint = 0.006) or heart failure (13% vs. without heart failure, 11%; Pint = 0.045)ConclusionsPA was associated with a reduced risk of all-cause mortality in older adults with and without CVD. The benefits of PA in patients with CVD, especially patients with stroke or heart failure, were greater than those without.
Effectiveness of Amiodarone in Preventing the Occurrence of Reperfusion Ventricular Fibrillation After the Release of Aortic Cross-Clamp in Open-Heart Surgery Patients: A Meta-Analysis
Authors: He Li-min , Zhang An , Xiong Bin 
Published: February 2022

ObjectiveTo evaluate the efficiency of amiodarone in preventing the occurrence of reperfusion ventricular fibrillation (RVF) after aortic cross-clamp (ACC) release in patients undergoing open-heart surgery.MethodsWe searched the Web of Science, Cochrane Library, EMBASE, and PubMed databases through January 2021 for relevant studies addressing the efficacy of amiodarone in preventing RVF after ACC release in patients undergoing cardiac surgery. A complete statistical analysis was performed using RevMan 5.3. Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated to express the results of dichotomous outcomes using random or fixed-effect models. The chi-square test and I2 test were used to calculate heterogeneity.ResultsSeven studies (856 enrolled patients; 311 in the amiodarone group, 268 in the lidocaine group, and 277 in the placebo group) were selected for the meta-analysis. The incidence of RVF was significantly decreased in the amiodarone group compared to the placebo group (RR = 0.69, 95%CI: 0.50–0.94, P = 0.02). However, amiodarone and lidocaine did not confer any significant difference (RR = 0.98, 95%CI: 0.61–1.59, P = 0.94). The percentage of patients requiring electric defibrillation counter shocks (DCSs) did not confer any significant difference between patients administered amiodarone and lidocaine or placebo (RR = 1.58, 95%CI: 0.29–8.74, P = 0.60; RR = 0.55, 95%CI: 0.27–1.10, P = 0.09; respectively).ConclusionsAmiodarone is more effective than a placebo in preventing RVF after ACC release in cardiac surgery. However, the amiodarone group required the same number of electrical DCSs to terminate RVF as the lidocaine or placebo groups.