bluuebunny/crossref_metadata_2025_split huggingface dataset:
False lumen thrombus following aortic dissection diagnosed as the source of repeat lower extremity emboli with angioscopy: a case report
Authors: Shimizu Riha , Sumi Makoto , Murakami Yuri , Ohki Takao 
Published: April 2022

Abstract
Background
Acute arterial embolization caused by a free-floating thrombus of the false lumen after surgery for acute aortic dissection is a rare complication; hence, determining its cause may be difficult. We report a case in which angioscopy was valuable in diagnosing and treating the unstable thrombus within the false lumen.

Case presentation
The patient was a 71-year-old woman who underwent hemiarch replacement for Stanford type A acute aortic dissection. Two months after the operation, left renal infarction occurred. Eighteen months after the operation, the patient visited the hospital for treatment of intermittent claudication of her left leg. Computed tomography (CT) showed occlusion below the left common femoral artery. Surgical thrombectomy was performed for acute lower extremity arterial occlusion. One month later, thrombectomy was performed again for the same phenomenon and again after 2 months. She had no history of cardiac arrhythmia. No obvious source for the repeat embolization could be found on echocardiography or enhanced CT. Angiography was performed to further identify the cause, revealing a new entry site at the distal anastomosis, which exhibited antegrade flow into the false lumen. Furthermore, selective false lumen angiography via the re-entry revealed a thrombus in the false lumen corresponding to the descending aorta. A non-obstructive angioscopy system in the false lumen revealed a free-floating thrombus. As the patient had undergone multiple surgeries over a short period and desired minimally invasive treatment, coil embolization of the new entry site as well as false lumen was performed. As a result, blood flow from the true to the false lumen resolved. More than 1 year has passed following coil embolization with no signs of embolism.

Conclusions
We experienced a case of repeat embolism caused by unstable thrombus formation in the false lumen resulting from antegrade blood flow in the false lumen secondary to development of a new entry site. Angioscopy revealed that this antegrade flow caused formation of an unstable thrombus which caused recurrent acute lower extremity arterial occlusion. Therefore, angioscopy may be a useful option for the diagnosis of false lumen thrombosis.
Phase contrast cardiac magnetic resonance imaging versus transoesophageal echocardiography for the evaluation of feasibility for transcatheter closure of atrial septal defects
Authors: Shah Tariq Rashid , Beig Jahangir Rashid , Choh Naseer Ahmad , Rather Fayaz Ahmad , Yaqoob Irfan , Jan Vicar Mohammad 
Published: April 2022

Abstract
Background
This prospective study was aimed at comparing phase contrast cardiac magnetic resonance imaging (PC-CMR) with 2D transoesophageal echocardiography (TEE) for determining potential candidature for transcatheter closure in ostium secundum ASD (OS-ASD) patients. We included consecutive adult patients with OS-ASD for the evaluation of feasibility for transcatheter closure using 2D-TEE and PC-CMR over a period of 2 years. Patients who fulfilled the conventional criteria for transcatheter closure, i.e. maximum ASD diameter ≤ 34 mm, adequate rims (≥ 5 mm, except for anterosuperior rim), and normal pulmonary venous drainage on both imaging modalities, were taken for device closure. In patients where there was discrepancy in the measurements of ASD diameter or rim size, making them eligible for device closure on one imaging modality and ineligible on the other hand, provisional device closure was attempted. All patients who underwent transcatheter closure were followed up to 6 months to rule out any complications.

Results
A total of 58 patients (mean age 35.93 ± 10.59 years) were enrolled in the study. Overall, there was significant positive correlation between 2D-TEE and CMR measurements of maximal ASD diameter and rim size (p < 0.001). However, TEE significantly underestimated maximal ASD diameter and posteroinferior rim size in comparison with CMR (p = 0.013 and p = 0.023, respectively). 46 (79.3%) patients were suitable for transcatheter closure on CMR, while 44 (75.9%) were eligible on TEE. Transcatheter closure was attempted in 48 patients based on imaging findings and was successful in 46 (95.8%) patients. Device closure was unsuccessful in 2 patients with defect size < 34 mm on TEE but > 34 mm on CMR. Among 7 patients with deficient posteroinferior rim on TEE, 5 had sufficient rim on CMR and underwent successful transcatheter closure. CMR detected anomalous pulmonary venous drainage in one patient which was missed on TEE, hence excluding the patient from transcatheter closure. Mean device size was 28.3 ± 7.4 mm and correlated more strongly with the defect dimensions on PC-CMR (r = 0.85, p < 0.001) compared to TEE (r = 0.71, p = 0.02).

Conclusions
PC-CMR may to be superior to 2D-TEE for the preprocedural planning and feasibility assessment for transcatheter closure in adult patients with ostium secundum ASD.
Modeling the enablers of online consumer engagement and platform preference in online food delivery platforms during COVID-19
Authors: Habib Aqib , Irfan Muhammad , Shahzad Mohsin 
Published: April 2022

AbstractDue to the COVID-19 outbreak globally during 2020, the usage and virtues of food delivery apps (FDA) have increased immensely, facilitating the consumer to access the food and food providers to keep functioning. However, this study aims to investigate the enablers of online consumer engagement (OCE) and platform preference in the foodservice industry, keeping in view the moderating role of peer pressure by following uses and gratifications theory (UGT). The data were collected from 322 FDA's user in China during the COVID-19 lockdown and analyzed employing partial least-square structural equation modeling (PLS-SEM). PLS-SEM results revealed that consumer’s self-concept and platform interactivity affect OCE and platform preference. Further, OCE mediates the effect of the relationship between platform interactivity, self-concept, and platform preference. Furthermore, peer pressure significantly moderates the relationship between OCE and platform preference. This research contributes to the prevailing body of literature in a novel way by employing UGT on consumer behavior in the FDA. The study has value for online food businesses and implications for consumers, retailers, and practitioners to formulate and implement value-added strategies in a consumption-oriented emerging economy.
Pre-existing Thyroid Autoimmunity and Risk of Papillary Thyroid Cancer: A Nested Case-Control Study of US Active-Duty Personnel
Authors: McLeod Donald S.A. , Bedno Sheryl A. , Cooper David S. , Hutfless Susan M. , Ippolito Silvia , Jordan Susan J. , Matos Peter G. , Neale Rachel E. , Sabini Elena , Whiteman David C. , Ladenson Paul W. , Caturegli Patrizio 
Published: April 2022

PURPOSE Thyroid autoimmunity has been associated with differentiated thyroid cancer although multiple potential biases might have influenced the results of previous studies. METHODS We conducted a case-control study nested within the cohort of US active-duty personnel 1996-2014 to assess the association between thyroid autoimmunity, defined by serology, and thyroid cancer diagnosis. The primary exposure was thyroid peroxidase (TPO) antibody status 7-10 years before the thyroid cancer index date. We also assessed whether diagnosis of thyroid autoimmunity mediated any associations identified and if thyroid cancer features differed by autoimmunity status. RESULTS Among 451 incident cases of papillary thyroid cancer and matched controls (median age 36 years, 61.4% men), TPO antibody positivity ( v negative) 7-10 years prediagnosis was associated with thyroid cancer (odds ratio [OR] 1.90 [95% CI, 1.33 to 2.70]). Exploratory analyses suggested an increasing risk of thyroid cancer with higher TPO antibody titer (TPO antibody 550-1,399 IU/mL: OR 2.95 [95% CI, 1.37 to 6.36]; and ≥ 1,400 IU/mL: OR 3.91 [95% CI, 1.66 to 9.24]). Positive TPO antibody status remained associated with thyroid cancer after those with diagnosed autoimmunity were excluded, and the association was not mediated by diagnosis of thyroid autoimmunity. Among the cases with diagnosed autoimmunity, 58% thyroid cancers were ≤ 10 mm diameter. CONCLUSION Longstanding prior thyroid autoimmunity up to 10 years before thyroid cancer diagnosis was associated with papillary thyroid cancer risk. The results could not be fully explained by diagnosis of thyroid autoimmunity although when autoimmunity had been identified, thyroid cancers were diagnosed at a very early stage.
Liver Fibrosis Marker and Postoperative Mortality in Patients Without Overt Liver Disease
Authors: Zelber-Sagi Shira , O’Reilly-Shah Vikas N. , Fong Christine , Ivancovsky-Wajcman Dana , Reed May J. , Bentov Itay 
Published: April 2022

BACKGROUND:
Nonalcoholic fatty liver disease (NAFLD) can progress to advanced fibrosis, which, in the nonsurgical population, is associated with poor hepatic and extrahepatic outcomes. Despite its high prevalence, NAFLD and related liver fibrosis may be overlooked during the preoperative evaluation, and the role of liver fibrosis as an independent risk factor for surgical-related mortality has yet to be tested. The aim of this study was to assess whether fibrosis-4 (FIB-4), which consists of age, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and platelets, a validated marker of liver fibrosis, is associated with postoperative mortality in the general surgical population.

METHODS:
A historical cohort of patients undergoing general anesthesia at an academic medical center between 2014 and 2018 was analyzed. Exclusion criteria included known liver disease, acute liver disease or hepatic failure, and alcohol use disorder. FIB-4 score was categorized into 3 validated predefined categories: FIB-4 ≤1.3, ruling out advanced fibrosis; >1.3 and <2.67, inconclusive; and ≥2.67, suggesting advanced fibrosis. The primary analytic method was propensity score matching (FIB-4 was dichotomized to indicate advanced fibrosis), and a secondary analysis included a multivariable logistic regression.

RESULTS:
Of 19,861 included subjects, 1995 (10%) had advanced fibrosis per FIB-4 criteria. Mortality occurred intraoperatively in 15 patients (0.1%), during hospitalization in 272 patients (1.4%), and within 30 days of surgery in 417 patients (2.1%). FIB-4 ≥2.67 was associated with increased intraoperative mortality (odds ratio [OR], 3.63; 95% confidence interval [CI], 1.25–10.58), mortality during hospitalization (OR, 3.14; 95% CI, 2.37–4.16), and within 30 days from surgery (OR, 2.46; 95% CI, 1.95–3.10), after adjusting for other risk factors. FIB-4 was related to increased mortality in a dose-dependent manner for the 3 FIB-4 categories ≤1.3 (reference), >1.3 and <2.67, and ≥2.67, respectively; during hospitalization (OR, 1.89; 95% CI, 1.34–2.65 and OR, 4.70; 95% CI, 3.27–6.76) and within 30 days from surgery (OR, 1.77; 95% CI, 1.36–2.31 and OR, 3.55; 95% CI, 2.65–4.77). In a 1:1 propensity-matched sample (N = 1994 per group), the differences in mortality remained. Comparing the FIB-4 ≥2.67 versus the FIB-4 <2.67 groups, respectively, mortality during hospitalization was 5.1% vs 2.2% (OR, 2.70; 95% CI, 1.81–4.02), and 30-day mortality was 6.6% vs 3.4% (OR, 2.26; 95% CI, 1.62–3.14).

CONCLUSIONS:
A simple liver fibrosis marker is strongly associated with perioperative mortality in a population without apparent liver disease, and may aid in future surgical risk stratification and preoperative optimization.
Human pluripotent stem cell-derived kidney organoids for personalized congenital and idiopathic nephrotic syndrome modeling
Authors: Jansen Jitske , van den Berge Bartholomeus T. , van den Broek Martijn , Maas Rutger J. , Daviran Deniz , Willemsen Brigith , Roverts Rona , van der Kruit Marit , Kuppe Christoph , Reimer Katharina C. , Di Giovanni Gianluca , Mooren Fieke , Nlandu Quincy , Mudde Helmer , Wetzels Roy , den Braanker Dirk , Parr Naomi , Nagai James S. , Drenic Vedran , Costa Ivan G. , Steenbergen Eric , Nijenhuis Tom , Dijkman Henry , Endlich Nicole , van de Kar Nicole C. A. J. , Schneider Rebekka K. , Wetzels Jack F. M. , Akiva Anat , van der Vlag Johan , Kramann Rafael , Schreuder Michiel F. , Smeets Bart 
Published: April 2022

ABSTRACT
Nephrotic syndrome (NS) is characterized by severe proteinuria as a consequence of kidney glomerular injury due to podocyte damage. In vitro models mimicking in vivo podocyte characteristics are a prerequisite to resolve NS pathogenesis. The detailed characterization of organoid podocytes resulting from a hybrid culture protocol showed a podocyte population that resembles adult podocytes and was superior compared with 2D counterparts, based on single-cell RNA sequencing, super-resolution imaging and electron microscopy. In this study, these next-generation podocytes in kidney organoids enabled personalized idiopathic nephrotic syndrome modeling, as shown by activated slit diaphragm signaling and podocyte injury following protamine sulfate, puromycin aminonucleoside treatment and exposure to NS plasma containing pathogenic permeability factors. Organoids cultured from cells of a patient with heterozygous NPHS2 mutations showed poor NPHS2 expression and aberrant NPHS1 localization, which was reversible after genetic correction. Repaired organoids displayed increased VEGFA pathway activity and transcription factor activity known to be essential for podocyte physiology, as shown by RNA sequencing. This study shows that organoids are the preferred model of choice to study idiopathic and congenital podocytopathies.
Effectiveness of 36 hospital learning centers in Thailand: continuation of child patient education, parent attitudes toward child’s illness and service satisfaction
Authors: Fuengfoo Adidsuda , Sakulnum Kim , Owjinda Sumitra 
Published: April 2022

Background: This study aimed to determine the effectiveness of 36 hospital learning centers for the continued education of sick children using electronic distance learning television (eDLTV), parents’ attitudes toward their child’s illnesses and education, and service satisfaction of the centers. Methods: The sample included 4,430 children aged 4-18 years old with common illnesses, chronic illnesses and developmental disorders, as well as 4,430 parents who had taken care of the child for at least 6 months. The methods included attitude surveys, which were analyzed using chi-square tests and t-tests. Results: The factors associated with education continuation of the children were illness types (parents were less worried about children with common illness and more concerned about education of children with chronic diseases and children with disabilities), distance from home to school, transportation type, parents’ education level, marital status, and family income. About 99.8% of patients with common illnesses continued their education, followed by 99.3% of disabled children, and 95.9% of chronic patients. Satisfaction score towards the services at the learning centers were high (mean scores: 4.28 and 4.43 respectively, out of 5 = strongly satisfied). Conclusion: After completing an education program through eDLTV at a center, a total of 97.7% of children continued their education and were highly satisfied with the service at the center. Parents had positive attitudes towards their child’s illnesses and education.
Predictive model for the intraoperative unresectability of hilar cholangiocarcinoma: Reducing futile surgical exploration
Authors: Song Jinglin , Lei Xiaofeng , Lin Heng , Dai Haisu , Liu Xingchao , Jiang Yan , Hu Feng , Li Yuancheng , Fan Haining , Zhang Leida , Chen Zhiyu , Zhang Chengcheng 
Published: April 2022

Introduction
Surgical exploration is widely performed in hilar cholangiocarcinoma (HCCA), but the intraoperative resectability rate is only 60%-80%. Exploration substantially increases pain and mental stress, and the costs and length of hospital stay are considerably increased. Identifying preoperative risk factors associated with unresectability could decrease unnecessary exploration.

Materials and methods
In total, 440 HCCA patients from multiple centers were enrolled. Those receiving surgical exploration were divided into the resected and unresected groups. Morphological variables including Bismuth classification, lymph node metastasis and vessel invasion were obtained from radiological exams. Logistic regression for the training cohort was used to identify risk factors for unresectability, and a nomogram was constructed to calculate the unresectability rate. A calibration curve assessed the power of the nomogram.

Results
Among 311 patients receiving surgical exploration, 45 (14.7%) were unresectable by intraoperative judgment. Compared with the resected group, unresected patients had similar costs (p = 0.359) and lengths of hospital stay (p = 0.439). Multivariable logistic regression of the training cohort (235 patients) revealed that CA125, Bismuth-Corlette type IV, lymph node metastasis and hepatic artery invasion were risk factors for unresectability. Liver atrophy (p = 0.374) and portal vein invasion (p = 0.114) were not risk factors. The nomogram was constructed based on the risk factors. The concordance index (C-index) values of the calibration curve for predicting the unresectability rate of the training and validation (76 patients) cohorts were 0.900 (95% CI, 0.835–0.966) and 0.829 (95% CI, 0.546–0.902), respectively.

Conclusion
Analysis of preoperative factors could reveal intraoperative unresectability and reduce futile surgical explorations, ultimately benefiting HCCA patients.
Characteristics of single-channel electroencephalogram in depression during conversation with noise reduction technology
Authors: Mitsukura Yasue , Tazawa Yuuki , Nakamura Risa , Sumali Brian , Nakagawa Tsubasa , Hori Satoko , Mimura Masaru , Kishimoto Taishiro 
Published: April 2022

Background
Previous studies have attempted to characterize depression using electroencephalography (EEG), but results have been inconsistent. New noise reduction technology allows EEG acquisition during conversation.

Methods
We recorded EEG from 40 patients with depression as they engaged in conversation using a single-channel EEG device while conducting real-time noise reduction and compared them to those of 40 healthy subjects. Differences in EEG between patients and controls, as well as differences in patients’ depression severity, were examined using the ratio of the power spectrum at each frequency. In addition, the effects of medications were examined in a similar way.

Results
In comparing healthy controls and depression patients, significant power spectrum differences were observed at 3 Hz, 4 Hz, and 10 Hz and higher frequencies. In the patient group, differences in the power spectrum were observed between asymptomatic patients and healthy individuals, and between patients of each respective severity level and healthy individuals. In addition, significant differences were observed at multiple frequencies when comparing patients who did and did not take antidepressants, antipsychotics, and/or benzodiazepines. However, the power spectra still remained significantly different between non-medicated patients and healthy individuals.

Limitations
The small sample size may have caused Type II error. Patients’ demographic characteristics varied. Moreover, most patients were taking various medications, and cannot be compared to the non-medicated control group.

Conclusion
A study with a larger sample size should be conducted to gauge reproducibility, but the methods used in this study could be useful in clinical practice as a biomarker of depression.
Poa probatovae (Poaceae), a new species from the Eastern Siberia
Authors: Olonova Marina V. , Chepinoga Viktor V. 
Published: April 2022

We describe a new species, Poa probatovae Olonova et Chepinoga, which occurs in the conifer forests of Tunkinskiye Goltsy Ridge (East Sayan Mts.) in the south of Republic of Buryatia (Eastern Siberia). Besides the protologue, we indicate the affinity of the new species and its geographical distribution. Assumptions about a possible relationship of P. probatovae are made as well. The new species is close to P. × intricata Wein (P. palustris L. × P. nemoralis L.) and P. remota Forcell but differs well from them by glabrous callus of the lemma, pubescence between the veins of lemma and between keels of palea. The described species is presumably endemic for Tunkinskiye Goltsy Ridge, but it is very likely found on other ridges of East Sayan Mts. and the Khamar-Daban Ridge.
On the natural interspecific hybrids of Ophrys mammosa Desf. s. l. and O. oestrifera M. Bieb. (Orchidaceae) from the Crimea and the North Caucasus
Authors: Fateryga Valentina V. , Ivanov Sergey P. , Popovich Anton V. , Fateryga Alexander V. 
Published: April 2022

Two natural interspecific hybrids of Ophrys mammosa Desf. s. l. and O. oestrifera M. Bieb. (O. × aghemanii Renz) are reported from Russia: a very rare O. mammosa subsp. mammosa × O. oestrifera from the Crimea (vicinity of Zelenogorye) and a relatively abundant O. mammosa subsp. caucasica (Woronow ex Grossh.) Soó × O. oestriferafrom the Krasnodar Territory (vicinity of Bolshoy Utrish). Males of Andrena carantonica Pérez are recorded as efficient pollinators of apparently both O. mammosa subsp. caucasica and O. oestrifera at the site where their hybrids occur.
New findings in the flora of Mongolia. Part 2
Authors: Kechaykin Aleksey A. , Shmakov Alexander I. , Batkin Alexander A. , Gundegmaa Vanzhil , Baasanmunkh Shuhandori , Oyuntsetseg Batlay , Choi Hyuk Jae , Gregor Thomas , Paule Juraj , Shaulo Dmitry N. , Korolyuk Andrey Yu. , Zibseev Andrey G. , Sinitsyna Tatyana A. , Smirnov Sergey V. 
Published: April 2022

New data on the distribution of 40 species from the families Asteraceae, Cystopteridaceae, Dryopteridaceae, Euphorbiaceae, Poaceae, Rosaceae, and Woodsiaceae in Mongolia are presented in the article. For the first time, Centaurea cyanus, Cystopteris almaatensis, Potentilla × habievii, Potentilla salsa, and Potentilla smirnovii are indicated for the flora of the country. 19 species previously known in the flora of Mongolia are new for its separate botanical and geographical regions. Of these, 7 taxa were found for the first time in the Khuvsgul, 5 – in the Khovd, 4 – in the Gobi Altai and 3 – in the Mongolian Altai regions, 2 each – in the Khangai, Khentei, and Dzungarian Gobi, 1 – in the Middle Khalkha. New locations were registered for 19 rare and endemic species of the study region. There are narrow local national endemics: Potentilla coriacea, P. inopinata, P. laevipes, and P. schmakovii, among them. The findings are divided into three groups in the article. Comments about the range, relationships and main morphological differences are given for each species. Photographic materials of Potentilla salsa made in nature on the territory of Mongolia are demonstrated for the first time.