bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing the 10-year risk of ischemic cardiovascular disease to receive early cardiovascular benefits from bariatric surgery for obesity in China
Authors: Li Yinhui , Liu Jia , Zhou Biao , Li Xiaohui , Wu Zhenyu , Meng Hua , Wang Guang 
Published: October 2022

BackgroundCardiovascular risk due to obesity can be improved greatly by bariatric surgery. However, there is no research involving appropriate model for evaluating cardiovascular disease risk reduction in bariatric surgery for obesity in China. We selected the ischemic cardiovascular disease (ICVD) risk score that accurately predict cardiovascular risk in Chinese adults to evaluate the 10-year risk of ICVD and estimated early cardiovascular benefits of bariatric surgery in obese Chinese patients through its reduction.MethodsFrom 2017 to 2019 we followed up 107 patients 6 months after surgery and measured the ICVD 10-year risk and other cardiovascular factors before and after surgery.ResultsThere were significant reductions in the ICVD total score (p &lt; 0.001) and ICVD 10-year risk (%) (p &lt; 0.001) 6 months post-operation compared with baseline. Furthermore, we found significant reductions in body mass index (BMI), body adiposity index (BAI), low-density lipoprotein (LDL), small dense-low-density lipoprotein (sd-LDL) and triglycerides (TG) 6 months after surgery compared with pre-operation (all p &lt; 0.05). The decrease in ICVD total score was correlated with excess BMI loss (%EBMIL), reduced BAI, reduced LDL, reduced sd-LDL and reduced TG respectively (all p &lt; 0.05) at 6 months post-operation. Moreover, there were significant reductions in the ICVD total score in the male subgroup [3 (3, 5) vs. 2.5 (2, 4), p &lt; 0.001] and female subgroup [3 (2, 4) vs. 2 (1, 3), p &lt; 0.001] 6 months post-operation compared with baseline. At last there were also significant reductions in the ICVD total score in the diabetic subgroup [5 (4, 6) vs. 4 (3, 5), p &lt; 0.001] and non-diabetic subgroup [2 (2,3) vs. 2 (1, 2), p &lt; 0.001] 6 months post-operation compared with baseline.ConclusionsBariatric surgery could provide early cardiovascular benefits for patients with obesity in China by reducing the 10-year risk of ICVD. Both men and women with obesity achieved cardiovascular benefits according to bariatric surgery, so did diabetic and non-diabetic patients.
Comprehensive recycling of fresh municipal sewage sludge to fertilize garden plants and achieve low carbon emission: A pilot study
Authors: Lin Xianke , Chen Canming , Li Huashou , Hei Liang , Zeng Luping , Wei Zebin , Chen Yangmei , Wu Qi-Tang 
Published: October 2022

Recycling nutrients in municipal sewage sludge (MSS) to soil would support sustainable development. In this study, a comprehensive recycling using specific plants able to grow in the fresh MSS and an indirect application technique was developed. Fresh MSS was placed in permeable containers next to Handroanthus chrysanthus plants to provide indirect fertilization. Sludge treatment plants (Alocasia macrorrhiza and Pennisetum hybridum) were grown directly on the Fresh MSS to produce plant biomass and treat MSS. The basal diameters of the H. chrysanthus plants were markedly increased by the treatment. Nutrients were extracted from MSS more readily and more biomass was produced by the P. hybridum than the A. macrorrhiza plants. The heavy metal contents of the soil did not increase significantly and not generate potential ecological risk, but the organic matter, nitrogen, and phosphorus contents increased markedly. The fresh MSS leachate met the relevant fecal coliform and heavy metal irrigation water standards. At the end of the treatment, the MSS mass had markedly decreased and the treated MSS was used as a seedling substrate for two garden plant seedlings. The net carbon emissions from the comprehensive recycling are estimated as -15.79 kg CO2e (CO2 equivalent) per ton fresh sludge, in contrast, the emissions from composting treatment are estimated as 8.15 kg CO2e. The method allows nutrients in MSS to be recycled without causing heavy metal pollution and without net carbon emission, while gives gardening products with commercial value.
Disturbance of the Warburg effect by dichloroacetate and niclosamide suppresses the growth of different sub-types of malignant pleural mesothelioma in vitro and in vivo
Authors: Lam Sze-Kwan , Yan Sheng , Lam Joyce Sze-Man , Feng Yuqian , Khan Mahjabin , Chen Caoyang , Ko Frankie Chi-Fat , Ho James Chung-Man 
Published: October 2022

Background: Inhalation of asbestos fibers is the most common cause of malignant pleural mesothelioma (MPM). In 2004, the United States Food and Drug Administration approved a combination of cisplatin with pemetrexed to treat unresectable MPM. Nonetheless novel treatment is urgently needed. The objective of this study is to report the combination effect of dichloroacetate (DCA) or niclosamide (Nic) Nic in MPM.Materials and methods: The effect of a combination of DCA and Nic was studied using a panel of MPM cell lines (H28, MSTO-211H, H226, H2052, and H2452). Cell viability was monitored by MTT assay. Glycolysis, oxidative phosphorylation, glucose, glycogen, pyruvate, lactate, citrate, succinate and ATP levels were determined by corresponding ELISA. Apoptosis, mitochondrial transmembrane potential, cell cycle analysis, hydrogen peroxide and superoxide were investigated by flow cytometry. Cell migration and colony formation were investigated by transwell migration and colony formation assays respectively. The in vivo effect was confirmed using 211H and H226 nude mice xenograft models.Results and conclusion: Cell viability was reduced. Disturbance of glycolysis and/or oxidative phosphorylation resulted in downregulation of glycogen, citrate and succinate. DCA and/or Nic increased apoptosis, mitochondrial transmembrane depolarization, G2/M arrest and reactive oxygen species. Moreover, DCA and/or Nic suppressed cell migration and colony formation. Furthermore, a better initial tumor suppressive effect was induced by the DCA/Nic combination compared with either drug alone in both 211H and H226 xenograft models. In H226 xenografts, DCA/Nic increased median survival of mice compared with single treatment. Single drug and/or a combination disturbed the Warburg effect and activated apoptosis, and inhibition of migration and proliferation in vivo. In conclusion, dichloroacetate and/or niclosamide showed a tumor suppressive effect in MPM in vitro and in vivo, partially mediated by disturbance of glycolysis/oxidative phosphorylation, apoptosis, ROS production, G2/M arrest, and suppression of migration and proliferation.
Long-Term Changes in Abundance and Composition of Forest-Floor Small Mammal Communities in a Landscape with Cumulative Clearcutting
Authors: Sullivan Thomas P. , Sullivan Druscilla S. 
Published: October 2022

Responses of forest-floor small mammals to clearcutting are species-specific with generalists occupying a range of habitats, and specialists persisting on clearcuts for variable periods. We investigated the responses in abundance and species composition of small mammal communities to cumulative clearcutting of coniferous forests on a landscape that had four independent clearcutting events (Periods 1 to 4) over a 42-year interval from 1979 to 2020 in south-central British Columbia, Canada. We ask if the small mammal communities have changed significantly over these decades owing to removal of old-growth forest by clearcut harvesting. Hypotheses (H) predicted that the small mammal community would (H1) increase in abundance, species richness, and diversity on new clearcuts owing to the availability of early seral post-harvest habitats from cumulative clearcutting; and (H2) have higher mean abundance, species richness, and species diversity in clearcut than uncut forest sites, owing to availability of vegetative food and cover. A third hypothesis (H3) predicted that abundance of (i) early seral vegetation (herbs and shrubs) and (ii) small mammal populations, will be greater in ungrazed clearcut sites than in those grazed by cattle (Bos taurus). Mean total numbers of small mammals on new clearcuts declined in Periods 3 and 4, and hence did not support the abundance part of H1. Much of this decline was owing to low numbers of the long-tailed vole (Microtus longicaudus) and meadow vole (M. pennsylvanicus). Two generalist species: the deer mouse (Peromyscus maniculatus) and northwestern chipmunk (Neotamias amoenus), contributed to high mean species richness and diversity in Periods 2 and 3 before these metrics declined in Period 4, and hence partly supported H1. The similarity in mean total numbers of small mammals in Periods 2 to 4 did not support the abundance prediction of H2 that total numbers would be higher in clearcut than uncut forest sites. Higher mean species richness (Periods 2 and 3) and diversity (Period 3) measurements on clearcut than forest sites, particularly in the early post-harvest years, did support these parts of H2. The vegetation part (i) of H3 was not supported for herbaceous plants but it was for shrubs. The small mammal part (ii) of H3 that populations would be higher in ungrazed than grazed clearcut sites was supported for abundance but not for species richness or diversity. The decline and near disappearance of both species of Microtus was possibly related to the reduction in plant community abundance and structure from grazing (at least for shrubs) and potentially from drought effects associated with climate change. Loss of microtines from these early seral ecosystems may have profound negative effects on various ecological functions and predator communities.
Effects of Heating on the Binding of Rare Earth Elements to Humic Acids
Authors: Wang Xiaomei , Deng Fan , Cheng Haijian , Ning Shuzheng , Li Baoqing , Pan Sidong , Yin Xuebo 
Published: October 2022

In deep underground environments, temperature is one of the key factors affecting the geochemistry behaviors of rare earth elements (REE) in organic-rich fluid. However, the influence of temperature on the interaction between humic acids (HA) and REE is not well known. In the present study, the influence of temperature on the HA–REE-binding behavior was evaluated based on heating experiments of REE-doped HA solution. Lignite-extracted HA and REE-binding experiments were conducted over a temperature range of 20 to 200 °C to quantify HA–REE complexation and the influence of temperature on HA binding sites. Results showed that increasing temperature and decreasing [REE]/[HA] ratio cause an increase of Kd value (the partition coefficient of REE between HA and aqueous solution). During heating KdREE KdREE patterns gradually change from middle REE-enriched-type (M-type) at 20 °C to light and middle REE-enriched-type (L-M-type) at 50 and 100 °C, and to light REE-enriched-type (L-type) at 150 °C and 200 °C. The increase of REE bonded with HA and modifications of KdREE patterns during the thermal treatment may be attributed to the increase of REE-binding sites, especially carboxylic sites, as a consequent of HA decomposition. This study provides a glimpse into the HA–REE-binding behaviors in the deep underground environment, which may shed light on the geochemical characteristics of REE in some organic-bearing rocks, and their changes during the coalification process.
Wellbore Temperature and Pressure Calculation of Offshore Gas Well Based on Gas–Liquid Separated Flow Model
Authors: Jing Jun , Shan Hongbin , Zhu Xiaohua , Huangpu Yixiang , Tian Yang 
Published: October 2022

Compared with land wells, the production environment and reservoir depth of offshore oil and gas wells are more complex and shallower. Further, HPHT production fluid there will produce strong temperature and pressure disturbance that affects the wellbore, which easily generates wellbore safety problems, such as wellhead growth and leakage caused by the incompatible deformation of casing and cement sheath. Therefore, obtaining an accurate wellbore temperature and pressure field is the key to implementing a wellbore safety assessment. Based on the gas–liquid two-phase separated method, this paper established an improved calculation model of wellbore temperature and pressure field for offshore HPHT wells. This model also takes into account the heat transfer environment characteristics of “formation-seawater-air” and the influence of well structure. Compared with the measured data of the case well, the error of temperature and pressure calculation results of the improved model are only 0.87% and 2.46%. Further, its calculation accuracy is greatly improved compared to that of the traditional gas–liquid homogeneous flow calculation model. Based on this model, the influencing factors of wellbore temperature and pressure in offshore gas wells are analyzed. The results show that forced convection heat exchange between seawater–air and wellbore is stronger than that between wellbore and formation. Reducing the gas–liquid ratio of the product can effectively reduce wellbore temperature and increase wellbore pressure. The gas production has a significant impact on the wellbore temperature. When the gas production rises from 10 × 104⋅m3/d to 60 × 104⋅m3/d, the wellhead temperature rises from 63 °C to 99 °C. However, due to the mutual influence of friction pressure drop and hydrostatic pressure drop, wellbore pressure increases first and then decreases with the increase in gas production. The improved model can provide a more accurate estimate of the time to reach the rated wellhead temperature. Meanwhile, this model displays accurate theoretical support for the rational formulation of the production plan after the well opening, so as to avoid excessive restrictions on the initial production rate.
L’interprétation de l’ancienne loi de Solon par Lysias X, 17 (Contre Théomnestos I) est-elle correcte ? Sur la place, la fonction et le sens du verbe ἐπιορκέω dans la langue des serments en grec ancien
Authors: Jouanna Jacques 
Published: October 2022

About a phrase of Solon’s law, Lysias X, 17 says that the participle ἐπιορκήσαντα is synonymous with ὀμόσαντα. All the dictionaries add, s. v.
ἐπιορκέω, to the general meaning «swear falsely » «forswear oneself » , this rare meaning of simply «to swear » by Solon apud Lysias. This synonymy was recently quoted to justify a variant reading in a papyrus of the Hippocratic Oath. The aim of the present paper is to criticize this alleged synonymy, by studying the meaning, the function and the position of ἐπίορκος and ἐπιορκέω in the oaths since Homer (literature, epigraphy, papyrology). The phrase of Solon’s law points really to the moment whereby the one who swears tells what should happen to himself if he swears falsely (ἐπιορκήσαντα), and gives the name of the God to call as witness at that time (Apollo). And finaly the paper deals with the difficult problem how to explain the formation of the compounds ἐπίορκος/ ἐπιορκέω/ ἐπιορκία vs. εὔορκος/ εὐορκέω/ εὐορκία.
PENERAPAN ALGORITMA K-MEANS CLUSTERING PADA PENGELOMPOKKAN PASANGAN USIA SUBUR PESERTA KB DI KABUPATEN CIREBON
Authors: Amelia Rizka , Martanto Martanto , Bahtiar Agus 
Published: October 2022

One of the problems faced by newly married couples is planning the birth of children in the family. The problem of regulating the birth spacing of children in the family can be regulated by the family planning program that has been launched by the Government. One way to suppress the problem of population growth rate in Indonesia is through the KB (Family Planning) program. The success of the family planning program can be seen from the contraceptive methods used by couples of childbearing age (PUS) in each region. The main purpose of this study was to determine the best group of couples of childbearing age for family planning participants based on the contraceptives used in Cirebon Regency using the K-means algorithm, where this algorithm can solve the clustering problem in determining the best group of couples of childbearing age family planning participants. The results of the clustering process to find the best group of couples of childbearing age for family planning participants by looking for the smallest DBI value and obtained K-2 as the best group with a Davies Bouldin Index value of 0.071. The best number of clusters from the grouping of fertile age couples for family planning participants is 2 clusters, cluster 0 has 20 items members and cluster 1 has 20 items members.

Keywords: Clustering, K-Means, Family planning(KB), Couples of childbearing age(PUS)
PEMANFAATAN POC LIMBAH RUMAH TANGGA DAN AIR KELAPA UNTUK PENINGKATAN PERTUMBUHAN TANAMAN CABAI MERAH (Capsicum annuum L)
Authors: Nuraida Waode , Putri Novita Pramahsari , Arini Rian , Hasan Rachmi Hariaty , Rakian Tresjia C , Yusuf Mani 
Published: October 2022

Pemanfaatan limbah rumah tangga sebagai pupuk organik merupakan solusi yang mudah, murah dan efektif karena sangat besar manfaatnya dalam hal lingkungan, ketahanan pertanian/pangan dan sosial budaya yang berkelanjutan. Cabai (Capsicum annum L.) merupakan tanaman sayuran yang banyak digemari masyarakat, dan memiliki nilai ekonomis tinggi. Penelitian ini bertujuan mengembangkan limbah rumah tangga (limbah sayuran dan buah) dan air kelapa yang berfungsi sebagai pupuk organik cair dan zat pengatur tumbuh dalam meningkatkan pertumbuhan tanaman cabai. Penelitian ini dilaksanakan di Jalan Ruruhi Lorong Sompu Andounohu Kota Kendari Sulawesi Tenggara, pada bulan Agustus sampai bulan November 2021. Sejumlah 48 polybag bibit tanaman cabai dipelihara di dalam 4 petakan ukuran 1x1x1 m3 dengan 1 petakan terdapat 3 polybag selama 65 hari. Rancangan penelitian yang digunakan adalah Rancangan Acak Kelompok, terdiri dari 4 perlakuan dengan 4 ulangan pada setiap percobaan. Perlakuan dosis pupuk cair limbah rumah tangga dan zpt air kelapa adalah P0 (0 ml/liter air), P1 (150 ml/liter air), P2 (200 ml/liter air), dan P3 (250 ml/liter air), Parameter yang diamati dalam penelitian ini meliputi tinggi tanaman, jumlah daun, diameter batang, luas daun dan produksi. Data hasil pengamatan terhadap masing-masing variabel yang diamati dianalisis berdasarkan sidik ragam. Apabila dalam analisis ragam terdapat pengaruh nyata maka dilakukan dengan uji berganda Duncan (UJBD) pada taraf nyata α = 0,05. Dari hasil analisis data secara statistik diperoleh bahwa perlakuan POC limbah rumah tangga dan ZPT berpengaruh nyata terhadap tinggi tanaman, jumlah daun dan luas daun. Hasil tersebut menunjukkan bahwa terdapat perbedaan pertumbuhan tanaman yang baik. Hasil terbaik pada pertumbuhan tanaman cabai yaitu pada perlakuan P2 (200 ml/liter air)
ANALISIS PROSES JAWABAN SISWA PADA KEMAMPUAN LITERASI MATEMATIKA SISWA MELALUI MODEL DISCOVERY LEARNING
Authors: Rahmadani Elfira , Saragih Sahat , Napitupulu E. Elvis , Sari Dwi Novita , Sirait Syahriani , Syafitri Ely 
Published: October 2022

Penelitian ini memiliki tujuan untuk mengetahui serta menganalisis aspek kemampuan literasi matematika siswa SMP Quran Kisaran pada materi segiempat. Sample yang diambil dalam penelitian ini adalah 32 orang siswa dari populasi seluruh siswa kelas VII SMP Quran Kisaran di ambil secara acak. Adapun jenis penelitian yang digunakan adalah deksriptif kualitatif. Instrumen penelitian adalah soal tes kemampuan literasi matematika berupa 3 butir soal essay serta wawancara. Hasil tes yang telah dilaksanakan pada beberapa soal literasi matematika menunjukan hasil yang baik. Terlihat dari presentase per indikator disetiap butir soal. Indikator pertama yaitu merumuskan masalah nyata dalam pemecahan masalah memperoleh hasil untuk butir soal 1, 2 dan 3 masing-masing sebanyak 90,62% (29 siswa), 84,37% (27 siswa), dan 81,25% (26 siswa). Indikator kedua yaitu menggunakan matematika dalam pemecahan masalah memperoleh hasil untuk butir soal 1, 2 dan 3 masing-masing sebanyak 93,87% (30 siswa), 90,62% (29 siswa), dan 87,5% (28 siswa). Indikator ketiga yaitu menafsirkan solusi dalam pemecahan masalah memperoleh hasil untuk butir soal 1, 2 dan 3 masing-masing sebanyak 84,37% (27 siswa), 81,25% (26 siswa), dan 87,5% (28 siswa). Kata Kunci : Proses Jawaban Siswa, Kemampuan Literasi Matematika, Model Discovery Learning
ANALISIS PROSES BERFIKIR SISWA DALAM MENYELESAIKAN SOAL MATEMATIKA PjBL
Authors: Rismawati Melinda , Hutagaol Anita Sri Rejeki , Dores Olenggius Jiran 
Published: October 2022

Pelaksanaan pembelajaran secara daring menjadi pilihan model pembelajaran yang dilakukan pada masa pandemi. Selama pandemic ini, siswa mengalami banyak kesulitan terutama belajar matematika secara online. Tujuan dari penelitian ini dilakukan yaitu untuk menjelaskan proses berfikir siswa dalam menyelesaikan soal matematika berbasis PjBL. Data dikumpulkan melalui pemberian tes, wawancara tidak terstruktur serta dokumentasi kepada 3 siswa dengan tingkat kognitif tinggi dilihat dari hasil belajar dan juga rekomendasi guru. Keabsahan data diuji dengan menggunakan trianggulasi, data dianalisis melalui pengumpulan data, reduksi, serta penarikan kesimpulan. Proses berfikir siswa , ,dan dalam menyelesaikan soal matematika PjBL dengan langkah start with the essensial question, design a pland for the project, create a schedule, monitor the students and the progress, assess the outcome and evaluate the experience.
ANALISIS FAKTOR PENGHAMBAT PENYELESAIAN STUDI MAHASISWA PROGRAM S1 PGSD UNIVERSITAS TERBUKA
Authors: Pakpahan Sondang Purnamasari , Sirait Syahriani 
Published: October 2022

Masalah dalam penelitian ini adalah banyaknya mahasiswa yang tidak dapat lulus tepat waktu. Tujuan dari penelitian ini adalah Untuk mengetahui apa sajakah faktor penghambat penyelesaian studi mahasiswa program S1 PGSD Universitas Terbuka. Populasi penelitian ini adalah seluruh mahasiswa program Studi PGSD yang belum menyelesaikan studi tepat waktu. Sampel diambil dengan cara random sampling dengan mempertimbangkan presentasi secara proposional dari setiap Kab/Kota yang dipilih sehingga mencapai 200 mahasiswa. Kab/Kota yang dipilih adalah Asahan, Batubara dan Tobasa. Teknik pengambilan data dilakukan dengan cara memberikan kuesioner/pertanyaan kepada responden Program Studi PGSD S-1 yang belum menyelesaikan studinya sampai batas waktu yang ditentukan sesuai Kurikulum S1 PGSD. Dari hasil penelitian dan analisis data diperoleh bahwa selain faktor karakteristik mahasiswa ada beberapa faktor lain yang menjadi penghambat penyelesaian studi mahasiwa S1 PGSD UPBJJ-UT yaitu motivasi belajar mahasiswa, cara belajar mahasiswa dan layanan UT. Rata-rata skor dari seluruh variabel termasuk dalam kategori baik.