bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for contralateral hip refractures in patients aged over 80 years with intertrochanteric femoral fractures
Authors: Yu Shujun , Li Chen , Zhong Yuqiao , Zang Jiacheng , Zhou Zhanzhe , Wang Song , Zhang Yinguang 
Published: September 2022

PurposeThe purpose of this study was to identify which of the risk factors would contribute to the contralateral fracture in very elderly patients after intramedullary nail fixation.MethodsClinical data of 227 intertrochanteric fracture patients aged 80 years or older were retrospectively reviewed. Intramedullary nails (IMNs) were used on all of the patients. Potential risk factors for contralateral hip refractures were determined using univariate and logistic regression analyses.ResultsContralateral hip refractures occurred in 11 patients (4.84%). Univariate analysis revealed that age, gender, body mass index, fracture classification, hematocrit, D-dimer, and CRP level were not associated with contralateral fractures (P &gt; 0.05). However, neurological diseases, cardiovascular disease, and visual impairments were significantly associated with contralateral fractures (P &lt; 0.05). Multivariate analysis further revealed that neurological diseases (OR 4.25, P = 0.044) and visual impairments (OR 5.42, P = 0.015) were independent risk factors associated with contralateral refractures.ConclusionTo prevent contralateral refractures, more attention should be paid to elderly intertrochanteric fracture patients with underlying neurological disease and visual impairments.
Case Report: Combining liver partition and portal vein ligation after thrombectomy for tumor isolation (CLAPT) to treat advanced hepatocellular carcinoma with portal vein tumor thrombosis
Authors: Jin Zongrui , Wu Guolin , Xu Banghao , Wang Jilong , Zhu Hai , Guo Ya , Peng Minhao , Peng Tao , Wen Zhang 
Published: September 2022

BackgroundPrimary liver cancer is the third leading cause of cancer-related deaths worldwide in 2020, and hepatocellular carcinoma (HCC) is the major pathological type. Patients with HCC complicated with portal vein tumor thrombosis (PVTT) have a poor prognosis, and controversies regarding treatment options exist among international scholars. Patients with VP4 or Cheng’s type III classification are generally considered ineligible for surgical treatment.MethodsWe retrospectively analyzed three cases of HCC with PVTT who underwent a novel modified surgical procedure. The procedure included portal vein thrombectomy and portal vein ligation with liver parenchymal separation for the resection of the tumor thrombus involving the main portal vein trunk and for the isolation of the giant tumor. The three cases were then treated with targeted drugs postoperatively.ResultsOne case developed acute renal failure in the perioperative period, and the renal function gradually recovered after the treatment. The two remaining cases recovered uneventfully postoperatively. The prognosis of the three patients was encouraging. Only one patient died of lung metastasis after 13 months, and the remaining patients were still alive after 41 and 21 months, respectively.ConclusionsWe provide a new possible surgical option for patients with advanced HCC with PVTT. The surgical procedure was inspired by associating liver partition with portal vein ligation for staged hepatectomy and portal vein thrombectomy. The survival time was significantly prolonged after the patients underwent thrombectomy, tumor isolation, and postoperative nonsurgical treatment. Hence, the combination of liver partition and portal vein ligation after thrombectomy for tumor isolation has the potential for the treatment of advanced HCC with PVTT.
GC–MS Untargeted Analysis of Volatile Compounds in Four Red Grape Varieties (Vitis vinifera L. cv) at Different Maturity Stages near Harvest
Authors: Gu Xiaobo , Zhang Xue , Wang Keqing , Lv Xi , Li Ruyi , Ma Wen 
Published: September 2022

Grape volatile compounds directly determine the aroma quality of wines. Although the aroma profile of grapes evolved greatly at different maturity stages, there were less considerations for aroma status when determining grape harvest time. In the present study, several maturation indicators, namely, sugars/acids ratio, free volatile compounds, bound volatile compounds and IBMP (3-isobutyl-2-methoxypyrazine) content were monitored in four red wine grape varieties (Vitis vinifera L. cv Cabernet Sauvignon, Cabernet Gernischet, Cabernet Franc and Merlot) near harvest time (42 days) in Ningxia, China. The results showed that the highest sugars/acids ratio was reached on day 21 and day 28 for Merlot and the other three varieties, respectively. For both free and bound volatile compounds, the content of carbonyl compounds decreased continuously in the process of ripening. The contents of free alcohols, esters and terpenes increased in the ripening stage and decreased in the stage of over-ripening. The accumulation of favorable bound aroma compounds peaked at day 35. The content of IBMP presenting a green smell in all four varieties descended continuously and kept steady from day 28. Therefore, the present findings revealed that the best aroma maturity time of four studied grape varieties was later than the sugars/acids ratio in Ningxia region. Aroma maturity should be taken into account during harvest time determination.
Genome-Wide Analysis of Calmodulin Binding Transcription Activator (CAMTA) Gene Family in Peach (Prunus persica L. Batsch) and Ectopic Expression of PpCAMTA1 in Arabidopsis camta2,3 Mutant Restore Plant Development
Authors: Yang Can , Li Zhihao , Cao Xiangmei , Duan Wenyi , Wei Chunyan , Zhang Chi , Jiang Dan , Li Mengtao , Chen Kunsong , Qiao Yongjin , Liu Hongru , Zhang Bo 
Published: September 2022

Calmodulin-binding transcription activator (CAMTA) is a transcription factor family containing calmodulin (CaM) binding sites and is involved in plant development. Although CAMTAs in Arabidopsis have been extensively investigated, the functions of CAMTAs remain largely unclear in peaches. In this study, we identified five peach CAMTAs which contained conserved CG-1 box, ANK repeats, CaM binding domain (CaMBD) and IQ motifs. Overexpression in tobacco showed that PpCAMTA1/2/3 were located in the nucleus, while PpCAMTA4 and PpCAMTA5 were located in the plasma membrane. Increased expression levels were observed for PpCAMTA1 and PpCAMTA3 during peach fruit ripening. Expression of PpCAMTA1 was induced by cold treatment and was inhibited by ultraviolet B irradiation (UV-B). Driven by AtCAMTA3 promoter, PpCAMTA1/2/3 were overexpressed in Arabidopsis mutant. Here, we characterized peach PpCAMTA1, representing an ortholog of AtCAMTA3. PpCAMTA1 expression in Arabidopsis complements the developmental deficiencies of the camta2,3 mutant, and restored the plant size to the wild type level. Moreover, overexpressing PpCAMTA1 in camta2,3 mutant inhibited salicylic acid (SA) biosynthesis and expression of SA-related genes, resulting in a susceptibility phenotype to Pst DC3000. Taken together, our results provide new insights for CAMTAs in peach fruit and indicate that PpCAMTA1 is associated with response to stresses during development.
The Effect of Short-Chain Fatty Acids on Growth of Cryptosporidium parvum In Vitro
Authors: Keelaghan Aidan P. , Charania Raheela , Mead Jan R. 
Published: September 2022

In a previous study, we observed an increase in the severity of cryptosporidial infection corresponding to decreased levels of short-chain fatty acids (SCFAs). Therefore, we decided to examine the effect of SCFAs on Cryptosporidium growth in human ileocecal adenocarcinoma (HTC-8) cells. HTC-8 cells were infected with 1 × 105 C. parvum oocysts. After 48 h of incubation with selected SCFAs, cells were fixed and labeled with monoclonal antibody directed to all intracellular stages, and the number of parasites was quantitated using a fluorescent microscope. Acetate, butyrate, propionate and valproate significantly inhibited growth, with an EC50 between 4 and 10 mM. Additionally, when combined, butyrate, acetate and propionate showed increased efficacy. Butyrate also inhibited growth when incubated with sporozoites prior to infection of host cell monolayers. In addition, we looked at possible mechanisms of action of inhibition. A combination of C. parvum infection and butyrate treatment led to increases in apoptosis and certain inflammatory cytokines. We conclude that acetate, propionate and butyrate have direct inhibitory activities in host cells against C. parvum, and butyrate can also affect sporozoite infectivity directly. While not preventing infection, SCFAs may help in keeping the infection low or in check.
Binding of Vialinin A and p-Terphenyl Derivatives to Ubiquitin-Specific Protease 4 (USP4): A Molecular Docking Study
Authors: Bailly Christian , Vergoten Gérard 
Published: September 2022

The para-terphenyl derivative vialinin A (Vi-A), isolated from Thelephora fungi, has been characterized as a potent inhibitor of the ubiquitin-specific protease 4 (USP4). Blockade of USP4 contributes to the anti-inflammatory and anticancer properties of the natural product. We have investigated the interaction of Vi-A with USP4 by molecular modeling, to locate the binding site (around residue V98 within the domain in USP segment) and to identify the binding process and interaction contacts. From this model, a series of 32 p-terphenyl compounds were tested as potential USP4 binders, mainly in the vialinin, terrestrin and telephantin series. We identified 11 compounds presenting a satisfactory USP4 binding capacity, including two fungal products, vialinin B and aurantiotinin A, with a more favorable empirical energy of USP4 interaction (ΔE) than the reference product Vi-A. The rare p-terphenyl aurantiotinin A, isolated from the basidiomycete T. aurantiotincta, emerged as a remarkable USP4 binder. Structure-binding relationships have been identified and discussed, to guide the future design of USP4 inhibitors based on the p-terphenyl skeleton. The docking study should help the identification of other protease inhibitors from fungus.
Ensiklopedia Digital Berdasarkan Klasifikasi Varietas Buah Mangga (Mangifera spp.) Menggunakan Algoritma Backpropagation
Authors: Fitri Zilvanhisna Emka , Aprilia Riska , Madjid Abdul , Imron Arizal Mujibtamala Nanda 
Published: September 2022

Mangga merupakan komoditas buah unggulan yang mampu meningkatkan perkembangan industri dan ekspor di Indonesia. Terdapat 33 spesies buah mangga yang tersebar di seluruh wilayah Republik indonesia dan memiliki banyak variasi bentuk pada setiap jenisnya. Namun permasalahan yang terjadi adalah sulitnya informasi terkait data pada varietas mangga, sehingga untuk membantu permasalahan tersebut maka peneliti membuat sistem ensiklopedia digital yang mampu memberikan informasi terkait keanekaragaman varietas buah mangga tersebut. Ensiklopedia ini dapat mengklasifikasikan dan mengidentifikasi 5 jenis mangga yaitu Mangga Apel, Mangga Gedong Gincu, Mangga Golek, Mangga Manalagi dan Mangga Gadung. Parameter yang digunakan untuk membedakan varietas mangga yaitu area, perimeter, eccentricity, major axis length dan diameter. Metode klasifikasi yang digunakan yaitu backpropagation mampu mengklasifikasi lima varietas mangga tersebut dengan akurasi pelatihan sebesar 99,6% dan akurasi pengujian sebesar 96%.
Kata Kunci â€“ ensiklopedia digital; varietas mangga; computer vision; parameter bentuk; backpropagation.
« L’indemnisation autonome du préjudice permanent exceptionnel n’est pas toujours illusoire ! »
Authors: Augier-Francia Émeline 
Published: September 2022

« Dès lors que le préjudice dont elle a constaté l’existence et qu’elle a entendu indemniser au titre du préjudice permanent exceptionnel ne l’avait pas été au titre du déficit fonctionnel permanent, la cour d’appel n’a pas méconnu le principe d’une réparation intégrale. »
Uji Efektivitas Ekstrak Daun Pepaya (Carica papaya L.) Sebagai Insektisida Alami Lalat Rumah (Musca domestica)
Authors: Piri Melany , Sumampouw Herry M , Moko Emma Mauren , Kamagi Decky W , Lawalata Helen 
Published: September 2022

The house fly (Musca domestica) is a vector of mechanical transmission of infectious diseases such as diarrhea, dysentery, cholera, typhoid. One way to control house flies is to use plant-based insecticides. Papaya leaves (Carica papaya L.) can be used as insecticides because of the enzymes saponins, flavonoids, and papain which are toxic to insects. This research aims to determine the effectiveness of papaya leaf extract as a natural insecticide for house flies. The concentration of papaya leaf extract used was 0%, 30%, 40%, 50%, and 60% with 3 replications. Each treatment unit contained 10 house flies. Extract application by spraying directly on house flies. The number of house fly deaths was calculated at 1, 2, 3, 4, 5, 6 and 24 hours. Data were analyzed using One Way Anova test. The result of this research was all the sig values are 0.00 < 0.05, which means that there was a significant difference in the number of house flies deaths at each concentration. In conclusion, the most effective concentration of papaya leaf extract to kill 100% of house flies was at a concentration of 60% after 6 hours of treatment.Keywords: house fly; natural insecticide; papaya leaf ABSTRAKSalah satu vektor penularan penyakit menular mekanis seperti diare, disentri, kolera, tipes adalah lalat rumah (Musca domestica). Salah satu cara pengendalian lalat rumah adalah menggunakan insektisida nabati. Daun pepaya (Carica papaya L.) mengandung enzim saponin, flavonoid, dan papain yang bersifat racun bagi serangga sehingga dapat digunakan sebagai insektisida alami atau insektisida nabati. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas ekstrak daun pepaya sebagai insektisida nabati lalat rumah menggunakan 5 perlakuan konsentrasi ekstrak kasar daun pepaya yakni 0%, 30%, 40%, 50%, dan 60% serta 3 ulangan, setiap unit perlakuan menggunakan 10 ekor lalat rumah, aplikasi ekstrak kasar daun pepaya dengan cara disemprotkan pada lalat rumah, jumlah kematian lalat rumah dihitung pada jam ke-1,2,3,4,5,6 dan 24 jam setelah aplikasi. Data dianalisis menggunakan uji One Way Anova. Hasil penelitian diperoleh semua nilai sig 0,00 < 0,05 yang berarti terdapat perbedaan bermakna jumlah kematian lalat pada setiap pemberian konsentrasi ekstrak daun pepaya. Hasil penelitian menunjukkan bahwa konsentrasi ekstrak daun pepaya yang paling efektif untuk membunuh 100% lalat rumah adalah konsentrasi 60% setelah 6 jam perlakuan.Kata kunci: daun pepaya; insektisida alami; lalat rumah
Pemanfaatan Vegetasi Rumput Brandjangan [Rottboellia cochinchinensis (Lour.) Clayton] oleh Beberapa Spesies Burung
Authors: Sumarto Saroyo , Hadi Islamul , Papu Adelfia 
Published: September 2022

Guinea fowl grass [Rottboellia cochinchinensis (Lour.)] as an invasive grass from Indian which distributed in the tropical to sub-tropical area has becoming a huge problematic in farm areas due to its adaptivity high growth speed. The aim of this study is to analyse is there any benefit of the guinea fowl grass. Object of study is the birds around the grass. It reveals that there are at least 15 species of birds are living in the guinea fowl grass: Cisticola juncidis, Passer montanus, Lonchura oryzivora, L. molucca, L. punctulata, Pycnonotus aurigaster, Turnix maculosus, Geopelia striata, Spilopelia chinensis, Hypotaenidia torquata, Aramidopsis plateni, Porphyrio indicus, Centropus bengalensis, Haliastur indus, dan Hirundo rustica. The birds use this habitat as many purposes, such as source of food (granivorous, insectivorous and omnivorous), associate with other organisms, breeding ground and hide. Keywords: Guinea fowl grass [Rottboellia cochinchinensis (Lour.); birds; daily activities; North Minahasa; North Sulawesi.ABSTRAK Rumput brandjangan [Rottboellia cochinchinensis (Lour.)] merupakan rumput invasif dari India, tersebar di daerah tropis dan subtropis dan menjadi permasalahan di daerah pertanian karena kecepatan tumbuh dan daya adaptif pada berbagai tipe habitat. Tujuan penelitian untuk mengkaji spesies burung yang memanfaatkan vegetasi rumput brandjangan. Penelitian dilaksanakan pada bulan Januari-Februari 2022 pada vegetasi rumput brandjangan di Kecamatan Kalawat, Kabupaten Minahasa Utara. Data dikumpul menggunakan metode ad libitum dengan mengambil seluruh data spesies burung dan seluruh aktivitas yang dilakukan pada vegetasi tersebut. Hasil penelitian menunjukkan terdapat 15 spesies burung: Cisticola juncidis, Passer montanus, Lonchura oryzivora, L. molucca, L. punctulata, Pycnonotus aurigaster, Turnix maculosus, Geopelia striata, Spilopelia chinensis, Hypotaenidia torquata, Aramidopsis plateni, Porphyrio indicus, Centropus bengalensis, Haliastur indus, dan Hirundo rustica. Aktivitas burung meliputi: mencari makan, makan, bersosial, beristirahat, kawin, dan bersembunyi. Rumput brandjangan menghasilkan biji sebagai sumber pakan burung granivora dan omnivore. Serangga pada vegetasi tersebut menjadi sumber pakan burung insektivora atau omnivora. Kata kunci: Rumput brandjangan [Rottboellia cochinchinensis (Lour.); burung; aktivitas harian; Minahasa Utara; Sulawesi Utara.
Aktivitas Antioksidan Ekstrak dan Fraksi dari Daun Kamboja Putih (Plumeria alba L.) terhadap 1,1-Difenilpikrilhidrazin (DPPH) (Antioxidant Activity of Extracts and Fractions of White Cambodian Leaves (Plumeria alba L.) against 1,1-Diphenylpicrylhydrazine (DPPH))
Authors: Anggoro Aloysius Barry , Wijaya Erlien Lusy , Elisa Novi 
Published: September 2022

Radikal bebas merupakan senyawa yang berperan dalam peningkatan resiko penyakit degeneratif yang mendominasi angka kematian di Indonesia. Antioksidan sebagai penangkal radikal bebas, salah satunya terdapat dalam daun kamboja. Daun kamboja putih dipilih karena relatif aman, ketersediaan yang melimpah, dan memiliki potensi sebagai antioksidan yang cukup menjanjikan. Penelitian ini bertujuan untuk menentukan aktivitas antioksidan dari ekstrak, partisi dan fraksi dari daun kamboja putih. Metode ekstraksi yang dipakai adalah remaserasi menggunakan pelarut metanol, dilanjutkan dengan partisi menggunakan pelarut n-heksana, etil asetat dan air. Partisi dengan IC50 paling rendah atau memiliki aktivitas antioksidan tertinggi selanjutnya difraksinasi dengan kromatografi kolom. Penentuan aktivitas antioksidan dengan metode DPPH dilakukan pada panjang gelombang 516,3 nm. Hasil penelitian menunjukkan bahwa partisi etil asetat memiliki IC50 terendah sebesar 94,43 ppm dibandingkan dengan partisi lainnya, sedangkan fraksi 2 memiliki daya antioksidan tertinggi diikuti fraksi 3 dan fraksi 1 dengan IC50 berturut-turut sebesar 54,11 ppm; 77,79 ppm dan 84,07 ppm.Kata kunci: Antioksidan; kamboja putih; metode DPPH; profil kromatografiABSTRACTFree radicals are compounds that play a role in increasing the risk of degenerative diseases that dominate mortality rates in Indonesia. Antioxidants as an antidote to free radicals, one of which is found in frangipani leaves. White frangipani leaves were chosen because they are relatively safe, abundantly available, and have promising potential as antioxidants. This study aims to determine the antioxidant effect of extracts, partitions, fractions from white frangipani leaves, and the thin layer chromatographic profile of the partition with the highest antioxidant activity. The extraction method being used was maceration using methanol followed by partioning the crude extract using n-hexane, ethyl acetate and water solvents. The partition with the lowest IC50 or having the highest antioxidant activity is then fractionated using column chromatography. The determination of antioxidant activity using DPPH method was performed at 516.3 nm. The results showed that the ethyl acetate partition had the lowest IC50 among other partitions (94.43 ppm), whereas fraction 2 had the highest antioxidant effect which was followed by fraction 3 and fraction 1 with IC50 respectively, 54.11 ppm; 77.79 ppm and 84.07 ppm.Keywords: Antioxidant; chromatography profil; DPPH method; white frangipani
Comparative studies on scintillation properties of Eu-doped CaAl2O4, SrAl2O4, and BaAl2O4 crystals
Authors: Nakauchi Daisuke , Kato Takumi , Kawaguchi Noriaki , Yanagida Takayuki 
Published: September 2022

Abstract
Eu:CaAl2O4, Eu:SrAl2O4, and Eu:BaAl2O4 crystals with various dopant concentration were synthesized by the optical floating zone method, and the photoluminescence, scintillation, and afterglow properties were investigated. Under X-ray irradiation, Eu:CaAl2O4 Eu:SrAl2O4, and Eu:BaAl2O4 exhibit a broad emission band at 440, 520, and 500 nm due to 5d-4f transitions of Eu2+, respectively. The decay time constants are consistent with the typical values of 5d-4f transitions of Eu2+. Photoluminescence quantum yield and scintillation light yield were evaluated, and each property was compared to comprehensively understand the characteristics.
Radiation-induced luminescence in oxide glasses
Authors: Masai Hirokazu , Yanagida Takayuki 
Published: September 2022

Abstract
Radiation-induced luminescence, and scintillation in particular, in glass is difficult to control, and its efficiency is hard to improve owing to the structural diversity of glasses. However, the structural and chemical compositional diversity and excellent formability of glass have remained attractive for phosphor applications. This paper summarizes recent studies on glass-based scintillators. Based on the general relationships between scintillation and photoluminescence quantum efficiency in materials, the prospects of glass-based scintillators are discussed.
Hubungan kadar gula darah dengan kebutuhan tidur pada pasien Diabetes Mellitus
Authors: Wahdi Achmad , Firdaus Rickiy Akbaril Okta , Indrawati Ucik , Puspitosari Dewi Retno , Arham Afif Hidayatul 
Published: September 2022

Tanda dan gejala khas yang dialami penderita Diabetes Mellitus, yaitu sering kencing pada malam hari (poliuria), selalu merasa haus (polidipsia), dan selalu merasa lapar (polifagia). Gejala banyak kencing ini terutama menonjol pada waktu malam hari, yaitu saat kadar gula dalam darah tinggi, hal ini tentu dapat mengganggu kuantitas dan kualitas tidur penderita Diabetes Mellitus. Tujuan penelitian untuk mengetahui hubungan kadar gula darah dengan kuantitas dan kualitas tidur pada penderita diabetes mellitus. Desain penelitian yaitu analitik korelasional dengan pendekatan retrospective. Variabel penelitian ada dua yaitu kadar gula darah sebagai variabel independen dan kuantitas serta kualitas tidur sebagai variabel dependen. Populasi penelitian yaitu seluruh pasien Diabetes Mellitus di Poli Interna RSI Sakinah Mojokerto sebanyak 37 pasien pada bulan Januari 2022. Sampel diambil dengan teknik purposive sampling sebanyak 28 responden. Data dikumpulkan dengan instrument kuesioner dan diuji spearman rho. Hasil penelitian menunjukkan dari 16 responden yang kadar gula darahnya terkontrol memiliki kualitas tidur yang baik 9 responden, sedangkan kuantitas tidur responden memiliki kuantitas tidur lebih 8 responden dan kuantitas tidur normal 7 responden. Hasil uji spearman rho menunjukkan nilai p value kualitas tidur = 0,001dan p value kuantitas tidur = 0,009 maka H0 ditolak artinya ada hubungan antara kadar gula darah dengan kebutuhan tidur penderita Diabetes Mellitus. Peningkatan kadar gula darah dapat mempengaruhi kebutuhan tidur responden. Oleh karena itu kontrol gula darah dapat dilakukan dengan menjaga pola tidur dan gaya hidup lebih sehat.