bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Medicinally Important Scondary Metabolites Landscape Through the Lens of Transcriptome Data in Fenugreek (Trigonella Foenum Graecum L.)
Authors: Naika Mahantesha B.N. , Sathyanarayanan Nitish , Sajeevan Radha Sivarajan , Bhattacharyya Teerna , Ghosh Pritha , Meenakshi Iyer S. , Jarjapu Mahita , Joshi Adwait G. , Harini K. , Shafi K. Mohamed , Kalmankar Neha V. , Karpe Snehal D. , Mam Bhavika , Pasha Shaik Naseer , Sowdhamini Ramanathan 
Published: March 2022

Abstract
Fenugreek (Trigonella foenum-graecum L.) is a self-pollinated leguminous crop belonging to the Fabaceae family. It is a multipurpose crop used as herb, spice, vegetable and forage. It is a traditional medicinal plant in India attributed with several nutritional and medicinal properties including antidiabetic and anticancer. We have performed a combined transcriptome assembly from RNA sequencing data derived from leaf, stem and root tissues. Around 2,09,831 transcripts were deciphered from the assembly of 92% completeness and an N50 of 1382 bases. Whilst secondary metabolites of medicinal value, such as trigonelline, diosgenin, 4-hydroxyisoleucine and quercetin, are distributed in several tissues, we report transcripts that bear sequence signatures of enzymes involved in the biosynthesis of such metabolites and are highly expressed in leaves, stem and roots. One of the antidiabetic alkaloid, trigonelline and its biosynthesising enzyme, is highly abundant in leaves. These findings are of value to nutritional and the pharmaceutical industry.
Efficient Adaptive Schemes to Use Reduced-Order Models for Fast Simulation of Water-Oil Displacement
Authors: Assareh Mehdi , Shirzad Goran , Poortoolabi Armin 
Published: March 2022

Abstract
Reservoir simulation is a CPU intensive task since it solves a set of fully implicit non-linear equations, the full-order model (FOM). Despite advances in computer processors, reducing simulation time is still a challenge especially for production optimization where hundreds of simulation runs are required. An acceptable approximation of reservoir dynamic model can be obtained when the model order is reduced. However, this leads to inaccuracies. These inaccuracies in the reduced-order models (ROMs) are addressed in here, using adaptive schemes to switch between the FOM and ROM. The proposed schemes are evaluated using coarse/fine grid homogenous and heterogenous case study models. These case studies are analyzed through 5-spot and inverted 5-spot patterns of production and injection wells for water flooding. Initially, the proper orthogonal decomposition (POD) is used to reduce the (FOM) for water flooding simulation. Snapshots are taken in FOMs’ runs to build ROMs. The average absolute deviation percent of the constructed ROMs relative to FOMs are less than 10% in most cases. The runtimes in ROMs are about 80% less than that of FOMs. A sensitivity analysis (based on case studies) is employed to determine the optimal period for snapshots and shock ranges. Three adaptive schemes (water breakthrough, injection-production intensity, and recovery factor) are proposed to switch between FOM and ROM in appropriate simulation timesteps. The best adaptive ROM scheme for heterogenous model is injection-production intensity while for homogenous reservoir model is recovery factor. This study shows increased accuracy for adaptive ROMs while simulation runtime is reduced by 50% for coarse homogenous and heterogonous reservoir models and 20% for the fine-grid model. ROM fidelity for inverted 5-spot pattern is more than that of 5-spot pattern.
Thoracic Endovascular Repair (TEVAR) for Blunt Traumatic Thoracic Aortic Injury: Long-Term Results.
Authors: Minici Roberto , Serra Raffaele , Ierardi Anna Maria , Petullà Maria , Bracale Umberto Marcello , Carrafiello Gianpaolo , Laganà Domenico 
Published: March 2022

Abstract
Background:Blunt traumatic thoracic aortic injury (TAI) is a critical injury with high mortality and an uncertain prognosis. In the last twenty years, thoracic endovascular repair (TEVAR) has become the treatment of choice compared to surgery, as it reduces mortality and morbidity. To date, a few studies evaluated long-term clinical and radiological follow-up of TEVAR for blunt traumatic TAI. The main concerns related to long-term follow-up relate to late endograft-related complications, morphological changes in the aorta and the consequences of life-long surveillance in terms of cumulative radiation dose.Results:Technical success was achieved in 38 procedures (100%). The TEVAR-related mortality rate was 0%. No immediate major complications related to the endovascular procedure were observed. The median duration of diagnostic follow-up was 80 months. A total of 4 procedure-related complications (10.5%) were identified at the follow-up. Three (7.9%) distal infoldings and collapses of the thoracic endoprosthesis and one (2.6%) type Ia endoleak were observed. No thrombosis of the prosthesis, nor signs of aortic pseudocoarctation were identified. No further complications related to endograft (endoleaks, infections, rupture, partial or complete thrombosis) occurred. No changes in the native aorta, stenosis, or increases in the endograft’s diameters were observed. A total of 20 patients (52.6%) underwent MRI-angiography examinations, while a total of 34 patients (89.5%) underwent chest radiographs at the follow-up. In all cases, CT-angiography examinations were performed at the follow-up.Conclusions:The consequences of lifelong surveillance deserve special consideration in younger patients treated with thoracic endovascular repair (TEVAR) for blunt traumatic thoracic aortic injury (TAI). Procedure-related complications were observed within one year of TEVAR, limiting concerns related to the durability of the prosthesis. No morphological changes in the aorta were observed despite long-term follow-up.
Fault-based Probabilistic Seismic Hazard Analysis in Regions with Low Strain Rates and a Thick Seismogenic Layer: A Case Study from Malawi
Authors: Williams Jack , Werner Maximillian , Goda Katsuichiro , Wedmore Luke , De Risi Raffaele , Biggs Juliet , Md Hassan , Dulanya Zuze , Fagereng Åke , Mphepo Felix , Chindandali Patrick 
Published: March 2022

Abstract
In low strain rate regions, extrapolation of incomplete instrumental earthquake records is a limitation for probabilistic seismic hazard analysis (PSHA). This limitation can be addressed by incorporating geologic and geodetic data into fault-based seismogenic sources, although it is not always clear how on-fault magnitude-frequency distributions should be described and, if the seismogenic layer is especially thick, how these sources should be extrapolated down-dip. We explore these issues in the context of a new PSHA for Malawi, where regional extensional rates are 0.5-2 mm/yr, the seismogenic layer is 30-40 km thick, the instrumental catalog is ~60 years long, and fault-based sources were recently collated in the Malawi Seismogenic Source Database. Furthermore, Malawi is one of several countries along the East African Rift where exposure to seismic hazard is growing, but PSHA typically considers instrumental records alone. We use stochastic event catalogs to explore different fault-source down-dip extents and magnitude-frequency distributions. These indicate that hazard levels are highest for a Gutenberg-Richter on-fault magnitude-frequency distribution, even at low probabilities of exceedance (2% in 50 years), whilst seismic hazard levels are also sensitive to how relatively short (<50 km) fault sources are extrapolated down-dip. For sites close to fault sources (<40 km), seismic hazard levels are doubled compared to previous instrumental-seismicity based PSHA in Malawi. Cumulatively, these results highlight the need for careful fault source modelling in PSHA of low strain rate regions, and the need for new fault-based PSHA elsewhere in East Africa.
Associaion of Gout with Crohn’s disease, and Inflammatory Bowel Disease with IgA Nephropathy: A Mendelian Randomization
Authors: Ye Chuyuan , Lu Jianhua , Liang Danna , Zhou Gongting , Yang Chenxin , Zhang Wei , Wu Hao , Huang Xiufeng , Yi Yongdong , Lin Limiao , Sun Weijian 
Published: March 2022

Abstract
Background: Gout and IgA nephropathy (IgAN) are two prevalent extra-intestinal symptoms of inflammatory bowel disease (IBD). However, no randomized controlled experiment has found a link between Crohn's disease (CD) and gout or IBD and IgAN. Thus, the causal relationship between IBD, gout, and IgAN is studied using two-sample Mendelian Randomization and Genome-wide association studies (GWAS) summary statistics. Methods: Several quality control processes were used to select qualified instrumental SNPs associated with exposure. To ensure the trustworthiness of the conclusion, inverse variance weighted, MR Egger, weighted median, and weighted mode methods were used. To estimate eligible instruments' stability, horizontal pleiotropy, and heterogeneity, leave-one-out analysis, MR-Egger intercept, and Cochran's Q test were used. Results: At a genetic level, MR analysis revealed that gout was associated with CD (IVW: P = 0.01). IBD was also found to increase the probability of IgAN (IVW: P = 4.77e-7). Conclusions: Gout increased the likelihood of CD, and IBD caused IgAN, according to a Mendelian randomization study. A larger sample size is required to discuss further the causal influence of gout on Crohn's disease.
RETRACTED: Isolation and Identification of Fungi from Egyptian Ras Cheese Made with some Probiotic Lactobacillus spp. with Reference to Their Toxins and Enzymes
Authors: Moneeb Asmaa H. M. , Zohri Abdel-Naser A. , Abd-Elmonem Mohammed A. , Tammam Adel A. , El-Desoki Wahid I. 
Published: March 2022

Abstract

The authors have requested that this preprint be removed from Research Square.
Hepatic and gastrointestinal manifestations in Mexican patients with juvenile systemic lupus erythematosus
Authors: Chavez Elizabeth Hernández , Coronel José María Alarid , Nuñez Myriam Mendez 
Published: March 2022

Abstract
Background: Systemic lupus erythematosus (SLE) is a multisystem disorder which can affect the gastrointestinal system (GI), symptoms can manifest in 50% of patients with systemic lupus erythematosus (SLE), these have barely been reviewed due to difficulty in identifying different causes [1]. The causes of abdominal pain in SLE patients are diverse, including lupus-related and non–lupus-related etiologies, as well as infections and medication side effects [2]. Children more often have lupus-related causes such as lupus mesenteric vasculitis, ascites peritonitis, and pancreatitis [2,3]. Liver manifestations, generally mild elevations in liver transaminases, have been reported in approximately 25-57.9% in paediatric-onset SLE (pSLE).Methods: Retrospective study, with review of 63 medical records of patients diagnosed with paediatric-onset SLE (pSLE) according to ACR 1997 criteria treated at the UMAE Hospital Pediatría CMNO, during the period from 2018 to 2020. Results: 63 patients were included, 49 (77.8%) girls and 14 (22.2%) boys, age range 5-17 years, mean 14 years (DS±2.9). Gastrointestinal involvement was recorded in 50.8% (n= 32) children. Lupus hepatitis, the most frequent digestive disorder (12.7%). Elevation of liver enzymes was detected in 31.7% with a higher elevation in patients with digestive disorders, in the case of AST (p= 0.001) and ALT (p= 0.024) Abdominal pain was the most frequent symptom, present in 38.1% (n= 24) patients, especially related to multiple medication 46% (n= 29), pancreatitis 7.9% (n=5), lupus enteritis 3.2% (n=2), intestinal pseud occlusion 1.6% (n=1) and ascites 1.6% (n= 1). A significant association was found (p= 0.03), among those patients with gastrointestinal affection and management with 4 or more drugs. Azathioprine was the drug most associated with abdominal pain (p= 0.07). Pancreatitis was associated with higher levels of disease activity by MEX SLEDAI score (p= 0.016). Of the manifestations not related to SLE, gastritis was the most frequent in 7.9% which was associated with a longer disease evolution time (p= 0.01).The decrease in C4 was the only immunological parameter significantly associated in patients with lupus and digestive disorders (P = 0.033). Conclusions: Gastrointestinal manifestations are common in paediatric-onset SLE (pSLE), but most of them are mild and due to adverse reactions to medications. Moderate elevation of liver enzymes occurred in 31.7% with significantly higher mean values of ALT and AST in patients with digestive disorders.
Trauma-informed care in UK: where are we? A qualitative study of health policies and professional perspectives
Authors: Emsley Elizabeth , Smith Joshua , Martin David , Lewis Natalia V 
Published: March 2022

Abstract
Background: Trauma-informed (TI) approach is a framework for a system change intervention that transforms the organisational culture and practices to address the high prevalence and impact of trauma on patients and healthcare providers and prevent re-traumatisation in healthcare services. Our systematic review of TI approaches in primary and community mental healthcare identified limited evidence for its effectiveness in the UK, despite endorsement in various policies. We aimed to explain the evidence-policy gap by analysing how and why TI approaches are represented, understood, and implemented in the UK.Methods: A qualitative study comprising of a document analysis of UK health policies followed by semi-structured interviews with key informants with direct experience of developing and implementing TI approaches. We used the Ready Extract Analyse Distil (READ) approach, and framework method.Results: We analysed 25 documents and interviewed 11 professionals from healthcare organisations and local authorities. Policies from healthcare organisations, local authorities, and Scottish and Welsh governments recommended TI approaches. However, there was no UK-wide strategy, agreed terminology and framework, or robust evidence base. Despite growing endorsement of TI approaches in policies, positive statements were not backed up with legislation, funding or resource allocation. Documents and interviews revealed differing understandings of TI approaches between geographical areas and across services, with disconnected, piecemeal implementation. Professionals explained the current landscape of TI approaches by the lack of high-level strategy and leadership, a need for adequate evaluation funding, and a lack of understanding of the term, existing frameworks and evidence available. They wanted more coordination and collaboration between organisations and regions. We identified factors that affected implementation of TI approaches at the level of organisation (leadership support, bottom-up and top-down development, presence of systemic thinking, organisational culture, resource allocation, competing priorities) and wider context (government support, funding, impact of the COVID-19 pandemic). Professionals had conflicting views on the future of TI approaches, however all agreed that government backing is essential for implementing policies into practice.Conclusions: A coordinated, centralised strategy on TI approaches in health systems, improved funding for evaluation, and education through professional networks about evidence-based TI health systems can increase value and reduce waste in research and implementation of TI approaches in the UK.
Validity of the methods evaluating the association between psychosocial stress and diabetes incidence and/ or control
Authors: shoher Shira , Toker Sharon , Cantrell Dror , Perl Kobi , Rapoport Micha J 
Published: March 2022

Abstract
Aims: Assessment of psychosocial stress remains a major obstacle in understanding its association with diabetes. We examined the validity of methods used to measure psychosocial stress in relation to diabetes incidence and control. Methods: 125 studies of psychosocial stress and diabetes published between 1983 and 2017 were evaluated. Evaluation included the stress type definition, study’s design, methodology of stress assessment and diabetes outcomes (incidence and/or control).Results: An association between stress and diabetes outcomes was found in 89% of studies. Prospective designs were commonly employed (38%), followed by cross-section designs (18%). More studies (64%) focused on psychosocial stress than sleep disorder related stress (22%). More studies explored diabetes incidence as an outcome (74%) than diabetes control (22%). The most common measure for stress assessment was a self-administered questionnaire (64%), followed by physiological indicators (7%). An analysis of the validity of the measures used, indicates that 67% of the studies used valid measures, with self-administered questionnaires exhibited a similar validity as other tools. Interestingly, the validity of tools used to evaluate sleep disorders severity was generally higher than those used to evaluate psychosocial stress.Conclusion: The majority of studies evaluating the association between anteceding stress and diabetes outcome applied valid measures.
The biological activities of 5,15-diaryl-10,20-dihalogeno porphyrins for photodynamic therapy
Authors: Li Man-Yi , Mi Le , Meerovich Gennady , Soe Thin Wut , Chen Ting , Than Ni-Ni , Yan Yi-Jia , Chen Zhi-Long 
Published: March 2022

Abstract
Purpose Esophageal cancer is the most common gastrointestinal tumor and is difficult to be eradicated with conventional treatment. Porphyrin-based photosensitizers (PSs) mediated photodynamic therapy (PDT) could kill tumor cells with less damage to normal cells. As the most widely used porphyrin-based photosensitizer in clinics, Photofrin II has excellent anti-tumor effect. However, it has some disadvantages such as weak absorption at near infrared region, the complexity of components and prolonged skin photosensitivity. Here series novel 5,15-diaryl-10,20-dihalogeno porphyrin derivatives were afforded and evaluated to develop more effective and safer photosensitizers for tumor therapy.Methods The photophysical properties and singlet oxygen generation rates of 5,15-diaryl-10,20-dihalogeno porphyrins (I1-6, II1-4) were tested. The cytotoxicity of I1-6 and II1-4 were measured by MTT assay. The pathway of cell death was studied by ﬂow cytometry. In vivo photodynamic efficacy of I3 and II2-4 in Eca-109 tumor-bearing BABL/c nude mice were measured and histopathological analysis were examined.Results 5,15-Diaryl-10,20-dihalogeno porphyrins I1-6 and II1-4 were synthesized. The longest absorption wavelength of these halogenated porphyrins (λmax = 660 nm) displayed a red shift around 30 nm compared to the unhalogenated porphyrins PS1 (λmax = 630 nm). The singlet oxygen generation rates of I1-6 and II1-4 were significantly higher than PS1 and HMME. All PSs mediated PDT showed obvious cytotoxic effect against Eca-109 cells compared to HMME in vitro and in vivo. Among these PSs, II4 exhibited appropriate absorption in the phototherapeutic window, higher 1O2 generation rate (k = 0.0061 s-1), the strongest phototoxicity (IC50 = 0.4 μM), lower dark toxicity in vitro on Eca-109 cells and excellent photodynamic anti-tumor efficacy in vivo. Besides, cell necrosis was induced by compound II4 mediated PDT.Conclusion All new compounds have obvious photodynamic anti-esophageal cancer effects. Among them, the photosensitizer II4 showed excellent efficacy in vitro and in vivo, which has the potential to become a photodynamic anti-tumor drug.
Flood Prediction and Risk Assessment at the South-western Region of Bangladesh
Authors: Meraz Md Musfike , Hossain Md. Riad , Sultana Rabeya , Esraz-Ul-Zannat Md. 
Published: March 2022

Abstract
Although Bangladesh has been experiencing frequent flooding that has made colossal damages to lives and properties, overseeing floods remains a difficult task. Due to the complexity, scale, and multidisciplinary nature of flood management, it is a multisectoral activity. Khulna and Satkhira districts, located in the south-western region of Bangladesh, are considered as one of the most vulnerable areas to flooding due to their economic potential, demographic makeup, and adaptive capacity of the population. This research focused on finding the most vulnerable areas to flooding for each polder within the study area. Water level data from fourteen stations of seven rivers (Sibsa, Rupsa-Pasur, Kobadak, Bhadra, Kobadak, Ichamati (Western Border), Betna-Kholpetua, and Satkhira Khal) were analyzed to calculate water levels for 2, 5, 10, 25, and 100-year return period applying normal distribution, Extreme Value Type-I (EV-I), and Log Person Type- III (LP-III) distribution methods. The EV-I distribution method was showing the best fit. The study revealed that station SW243 (Rupsa-Pasur river) in the Dacope region has the most extreme water level, station SW259 (Sibsa river) has the second-highest water level, and station SW254.5 (Satkhira Khal) in Satkhira Sadar has the third-highest water level for the return period of 100 years. A flood inundation map was prepared using the EV-I method's 10-year return period value. The Analytic Hierarchy Process (AHP) was used to demonstrate the polders' vulnerability depending on several factors. Overall, polder15 (Ghubra, Satkhira) is the most vulnerable polder, while polder 33 and polder 32 respectively are the second and third most vulnerable polders for flooding, both located in the Dacope region.
The Relationship Among Adolescents’ Self-esteem, Emotional Intelligence and Friendship Quality
Authors: Ye WEI 
Published: March 2022

Abstract
Background: The purpose of this study is to analyze the relationship among self-esteem, emotional intelligence and friendship quality of adolescents. Methods: A total of 333 adolescents were investigated with the help of a questionnaire and the qualitative data of interviews were used to demonstrate the results. The data were analyzed by exploratory analysis and typical correlation analysis. Results: Self-esteem can explain 21.3% of the variance of friendship quality. All levels of self-esteem are positively correlated with company help, intimate communication, positive value, trust and respect in friendship quality, but negatively correlated with conflict and betrayal in friendship quality. Emotional intelligence can explain 36.4% of the variance of friendship quality, and all levels of emotional intelligence are positively related to the level of companionship, intimate communication, positive value, trust and respect in friendship quality, but negatively related to the level of conflict and betrayal in friendship quality. Conclusion: There is a typical relationship among self-esteem, emotional intelligence and friendship quality, and interpersonal self-esteem, trust and respect, companionship and help, and intimate communication are the main explanatory factors. Emotional adjustment, cognitive reappraisal, emotional control and company help, trust and respect, positive value, intimate communication are the main explanatory factors.