bluuebunny/crossref_metadata_2025_split huggingface dataset:
The sustainability challenge of product information quality in the design and construction of facades: lessons from the Grenfell Tower fire
Authors: Bahrami Soheila , Zeinali Davood 
Published: January 2022

PurposeThis paper explores the quality and flow of facade product information and the capabilities for avoiding the risk of facade fires early in the design process.Design/methodology/approachA qualitative case study using the process tracing method is conducted in two stages. First, a thematic analysis of reports and literature identified two categories for the problems that caused fast fire spread across the Grenfell Tower facade. This enabled classifying the identified problems into four stages of a facade life cycle: product design and manufacturing, procurement, facade design and construction. Second, the capabilities for avoiding the problems were explored by conducting in-depth interviews with 18 experts in nine countries, analyzing design processes and designers' expertise and examining the usability of three digital interfaces in providing required information for designing fire-safe facades.FindingsThe results show fundamental flaws in the quality of facade product information and usability of digital interfaces concerning fire safety. These flaws, fragmented design processes and overreliance on other specialists increase the risk of design defects that cause fast fire spread across facades.Practical implicationsThe findings have implications for standardization of building product information, digitalization in industrialized construction and facade design management.Originality/valueThis research adds to the body of knowledge on sustainability in the built environment. It is the first study to highlight the fundamental problem of facade product information, which requires urgent attention in the rapid transition toward digital and industrialized construction.
Fabrication and characterization of screen printed NiMn2O4 spinel based thermistors
Authors: Uppuluri Kiranmai , Szwagierczak Dorota 
Published: January 2022

Purpose
The purpose of this work was to characterize NiMn2O4 spinel-based thermistor powder, to use it in screen printing technology to fabricate temperature sensors, to study their performance for different sintering temperatures of thermistor layer, with and without insulative cover, as well as to investigate stability of the fabricated thermistors and their applicability in water quality monitoring.

Design/methodology/approach
After the characterization of starting NiMn2O4 spinel-based thermistor powder, it was converted to thick film paste which was screen printed on alumina substrate. Thermistor layers were sintered at four different sintering temperatures: 980°C, 1050°C, 1150°C and 1290°C. An interdigitated pattern of Ag-Pd conductive layer was used to reduce the resistance. Temperature-resistance characteristics were investigated in air and water, with and without insulative cover atop the thermistor layer. Stability of the fabricated thermistors after aging at 120°C for 300 h was also examined.

Findings
Thick film NiMn2O4 spinel thermistors, prepared by screen printing and sintering in the temperature range 980°C–1290°C, exhibited good negative temperature coefficient (NTC) characteristics in the temperature range −30°C to 145°C, including high temperature coefficient of resistance, good stability and applicability in water.

Originality/value
This study explores the range of sintering temperature that can be applied for NiMn2O4 thermistor thick films without compromising on the temperature sensing performance in air and water, as well as stability of the thermistors after aging at elevated temperatures.
Exploring ethical consumption of generation Z: theory of planned behaviour
Authors: Djafarova Elmira , Foots Sophie 
Published: January 2022

PurposeThis study aims to explore the factors that encourage Generation Z consumers to turn an ethical purchase intention into purchase behaviour. Theory of planned behaviour model is applied to understand the Generation Z ethical consumerism.Design/methodology/approachQualitative method in the form of 18 semi-structured interviews was conducted on participants aged within the Generation Z cohort in the UK.FindingsResearch findings show that Generation Z has strong awareness and desire towards ethical and environmental issues. Driven in the main by the cohorts unlimited exposure to social media platforms and online resources where information is shared. Generation Z’s frugality limits them to purchase truly ethically in their current life stage. Financial aspirations from this target market suggest a future desire to purchase high value ethical items. Further trends discovered highlighted sustainable lifestyle choices within the generation. Recycling, diet choices and reduced consumption on clothing were expressed. The paper highlights that Generation Z are aware of ethical issues prevalent in society and are doing what they can at this life stage to make a positive impact.Practical implicationsThis research has valuable implications for both academics and marketers. It provides new insights for scholars into understanding Generation Z decision-making in ethical consumption. It successfully applied the Theory of Planned Behaviour to understand generational consumer behaviour. The findings can assist practitioners to determine effective marketing strategies to persuade Generation Z to act ethically. The research can also be considered when dealing with government legislation when tackling social change in younger population as this appeared important factor for the researched consumers. Marketers should also consider digital influencers as part of their communication campaigns targeting Generation Z users.Originality/valueThis search offers a valuable contribution to current academic findings towards Generation Z research as ethical consumers incorporating TPB framework.
Effects of year of post‐secondary study on reading skills for L1 and L2 speakers of English
Authors: McCarron Sean Patrick , Kuperman Victor 
Published: January 2022

BackgroundPrevious studies show that students improve communication skills throughout post‐secondary study proportionately to first‐year ability, yet important questions remain. How does post‐secondary affect the development of reading comprehension and related skills? How does this development vary between L1 and L2 speakers, and how much change occurs each year?MethodsWe administered a cross‐sectional battery of tests of reading proficiency to undergraduate university students in all years of study. The tests included measures of reading comprehension and multiple component skills: vocabulary, spelling, print exposure, reading habits and motivation.ResultsResults show that year of study confers a direct effect on component skills of reading. Skill trajectories of L1 and L2 students vary widely – across all skills tested, L1 students in Year 4+ show an average advantage of 12.60 percentile points compared with those in Year 1, whereas the average advantage of L2 students in Year 4+ over Year 1 peers is 29.20 percentile points. No difference between L1 and L2 readers, or between years of study, was observed in reading comprehension.ConclusionsPost‐secondary education confers sizable benefits to all examined component skills of English reading, especially in L2 students. While L2 students in Year 1 are disadvantaged in most skills, L2 students in Year 4+ close the performance gap with L1 speakers on all skills. This suggests an ‘anti‐Matthew’ effect, with most benefits seen in the initially underperforming population. These findings quantify the effectiveness of university itself and also its differential impact on students with different language backgrounds. The apparent dissociation between a change in component skills of reading and stability in reading comprehension scores remains puzzling: we outline avenues for further investigation of this issue.
The potential of bacteriophages to control Xanthomonas campestris pv. campestris at different stages of disease development
Authors: Holtappels Dominique , Fortuna Kiandro J. , Moons Lauren , Broeckaert Nand , Bäcker Léon E. , Venneman Sofie , Rombouts Sofie , Lippens Louis , Baeyen Steve , Pollet Sabien , Noben Jean‐Paul , Oechslin Frank , Vallino Marta , Aertsen Abram , Maes Martine , Van Vaerenbergh Johan , Lavigne Rob , Wagemans Jeroen 
Published: January 2022

SummaryXanthomonas campestris pv. campestris (Xcc) is a vascular pathogen that invades the xylem of Brassica crops. Current chemical and antibiotics‐based control measures for this bacterium are unsustainable and inefficient. After establishing a representative collection of Xcc strains, we isolated and characterized bacteriophages from two clades of phages to assess their potential in phage‐based biocontrol. The most promising phages, FoX2 and FoX6, specifically recognize (lipo) polysaccharides, associated with the wxc gene cluster, on the surface of the bacterial cell wall. Next, we determined and optimized the applicability of FoX2 and FoX6 in an array of complementary bioassays, ranging from seed decontamination to irrigation‐ and spray‐based applications. Here, an irrigation‐based application showed promising results. In a final proof‐of‐concept, a CaCl2‐formulated phage cocktail was shown to control the outbreak of Xcc in the open field. This comprehensive approach illustrates the potential of phage biocontrol of black rot disease in Brassica and serves as a reference for the broader implementation of phage biocontrol in integrated pest management strategies.
Oligomerization engineering of the fluorinase enzyme leads to an active trimer that supports synthesis of fluorometabolites in vitro
Authors: Kittilä Tiia , Calero Patricia , Fredslund Folmer , Lowe Phillip T. , Tezé David , Nieto‐Domínguez Manuel , O’Hagan David , Nikel Pablo I. , Welner Ditte H. 
Published: January 2022

SummaryThe fluorinase enzyme represents the only biological mechanism capable of forming stable C–F bonds characterized in nature thus far, offering a biotechnological route to the biosynthesis of value‐added organofluorines. The fluorinase is known to operate in a hexameric form, but the consequence(s) of the oligomerization status on the enzyme activity and its catalytic properties remain largely unknown. In this work, this aspect was explored by rationally engineering trimeric fluorinase variants that retained the same catalytic rate as the wild‐type enzyme. These results ruled out hexamerization as a requisite for the fluorination activity. The Michaelis constant (KM) for S‐adenosyl‐l‐methionine, one of the substrates of the fluorinase, increased by two orders of magnitude upon hexamer disruption. Such a shift in S‐adenosyl‐l‐methionine affinity points to a long‐range effect of hexamerization on substrate binding – likely decreasing substrate dissociation and release from the active site. A practical application of trimeric fluorinase is illustrated by establishing in vitro fluorometabolite synthesis in a bacterial cell‐free system.
Large‐scale brain network activation during emotional inhibitory control: Associations with alcohol misuse in college freshmen
Authors: Cohen‐Gilbert Julia E. , Nickerson Lisa D. , Seraikas Anna M. , Oot Emily N. , Rieselbach Maya M. , Schuttenberg Eleanor M. , Sneider Jennifer T. , Silveri Marisa M. 
Published: January 2022

AbstractBackgroundThe transition to college is associated with increased risk of alcohol misuse and a consequent increase in negative, alcohol‐related social and health impacts. Traits associated with ongoing brain maturation during this period, including impulsivity in emotional contexts, could contribute to risky alcohol use.MethodsThis functional magnetic resonance imaging (fMRI) study examined brain network activation strength during an emotional inhibitory control task (Go‐NoGo), which required participants to ignore background images with negative or neutral emotional valence during performance. Participants were 60 college freshmen (aged 18–20 years, 33 women). Survey measures, completed at baseline and one‐year follow‐up (follow‐up n = 52, 29 women), assessed alcohol misuse alcohol use disorders identification test (AUDIT), alcohol/substance use counseling center assessment of psychological symptoms (C‐CAPS), and negative consequences of alcohol use young adult alcohol consequences questionnaire (YAACQ). Measures were examined relative to network activation strength, on the Negative NoGo > Neutral NoGo contrast, of four large‐scale brain networks implicated in top‐down regulation of cognition and attention: right and left lateral frontoparietal networks (rL‐FPN; lL‐FPN), dorsal attention network (DAN), and salience network (SN).ResultsActivation strength of DAN was negatively associated with scores on the AUDIT (p = 0.013) and YAACQ (p = 0.004) at baseline, and with C‐CAPS score at baseline and follow‐up (p = 0.002; p = 0.005), and positively associated with accuracy on NoGo trials with negative backgrounds (p = 0.014). Activation strength of rL‐FPN was positively associated with C‐CAPS score at follow‐up (p = 0.003). SN activation strength was negatively associated with accuracy on NoGo trials with negative (p < 0.001) and neutral (p = 0.002) backgrounds and with the accuracy difference between negative versus neutral NoGo trials (p = 0.003).ConclusionThese findings suggest that less engagement of large‐scale brain circuitry that supports top‐down attentional control, specifically during negative emotions, is associated with more problematic drinking in emerging adults who attend college. This pattern of network activation may serve as a risk marker for ongoing self‐regulation deficits during negative emotion that could increase risk of problematic alcohol use and negative impacts of drinking.
The effects of cannabis and alcohol on driving performance and driver behaviour: a systematic review and meta‐analysis
Authors: Simmons Sarah M. , Caird Jeff K. , Sterzer Frances , Asbridge Mark 
Published: January 2022

AbstractBackground and aimsCannabis and alcohol are frequently detected in fatal and injury motor vehicle crashes. While epidemiological meta‐analyses of cannabis and alcohol have found associations with an increase in crash risk, convergent evidence from driving performance measures is insufficiently quantitatively characterized. Our objectives were to quantify the magnitude of the effect of cannabis and alcohol—alone and in combination—on driving performance and behaviour.MethodsSystematic review and meta‐analysis. We systematically searched Academic Search Complete, CINAHL, Embase, Scopus, Google Scholar, MEDLINE, PsycINFO, SPORTDiscus and TRID. Of the 616 studies that underwent full‐text review, this meta‐analysis represents 57 studies and 1725 participants. We extracted data for hazard response time, lateral position variability, lane deviations or excursions, time out of lane, driving speed, driving speed variability, speed violations, time speeding, headway, headway variability and crashes from experimental driving studies (i.e. driving simulator, closed‐course, on‐road) involving cannabis and/or alcohol administration. We reported meta‐analyses of effect sizes using Hedges’ g and r.ResultsCannabis alone was associated with impaired lateral control [e.g. g = 0.331, 95% confidence interval (CI) = 0.212–0.451 for lateral position variability; g = 0.198, 95% CI = 0.001–0.395 for lane excursions) and decreased driving speed (g = –0.176, 95% CI = –0.298 to –0.053]. The combination of cannabis and alcohol was associated with greater driving performance decrements than either drug in isolation [e.g. g = 0.480, 95% CI = 0.096–0.865 for lateral position variability (combination versus alcohol); g = 0.525, 95% CI = 0.049–1.002 for time out of lane (versus alcohol); g = 0.336, 95% CI = 0.036–0.636 for lateral position variability (combination versus cannabis; g = 0.475, 95% CI = 0.002–0.949 for time out of lane (combination versus cannabis)]. Subgroup analyses indicated that the effects of cannabis on driving performance measures were similar to low blood alcohol concentrations. A scarcity of data and study heterogeneity limited the interpretation of some measures.ConclusionsThis meta‐analysis indicates that cannabis, like alcohol, impairs driving, and the combination of the two drugs is more detrimental to driving performance than either in isolation.
Mortality trends after extracorporeal membrane oxygenation support: A Korean Nationwide cohort
Authors: Oh Tak Kyu , Cho Hyoung‐Won , Song In‐Ae 
Published: January 2022

AbstractBackgroundThis study aimed to investigate the prevalence of 7‐, 30‐, 60‐, and 365‐day overall and cause‐specific mortality following extracorporeal membrane oxygenation (ECMO) support.MethodsThe National Health Insurance claims database in South Korea was the data source for this population‐based cohort study. We enrolled all adult patients aged ≥18 years receiving intensive care unit ECMO support from January 1, 2005 to December 31, 2018. The study population was divided into three groups based on the main diagnoses during ECMO support: (1) cardiovascular, (2) respiratory, and (3) other diagnoses group (all other main diagnoses rather than cardiovascular or respiratory diseases).ResultsA total of 18 697 patients were included in the final analysis (64.5%, 10.9%, and 24.6% in the cardiovascular, respiratory, and other groups, respectively). The corresponding 7‐, 30‐, 60‐, and 365‐day mortality rates in these groups were 33.1%, 56.1%, 62.4%, and 67.7%. Kaplan–Meier curves demonstrated that the median survival time was shortest in the cardiovascular group (12.0 days, 95% confidence interval [CI]: 11.3–12.7), with 31.0 (95% CI: 28.5–33.6) and 49.0 (95% CI: 44.4–57.6) day survival in the respiratory and other diagnoses groups (p < 0.001).ConclusionsApproximately one‐third of patients died within 7 days, half of the patients died within 30 days, and two‐thirds died within 365 days of ECMO support. Overall survival time was shortest in the cardiovascular group, followed by that of the respiratory group.
Social capital and structural disadvantages: A case of Community‐Driven Development program in Afghanistan
Authors: Noori Hadi 
Published: January 2022

AbstractThis paper analyzes and uses the National Solidarity Program (NSP) Afghanistan as a case study to question the idea of social capital building for poverty reduction. Specifically, it explores how development policy has been decoupled from its intended objectives as it hit the existing friction in the ground. The data draws from poor household experience in three different provinces of Afghanistan to assess how poor household is integrated into NSP and how existing social structure and relational dynamics shape the NSP outcomes. The finding reveals that household is experiencing a cluster of interlink disadvantages that make it impossible for them to draw on social capital to reduce their poverty. However, NSP failed to eliminate the asymmetrical relations which created poverty in rural society; instead, it boosted Neopatrimonialism culture.
Euclid's Random Walk: Developmental Changes in the Use of Simulation for Geometric Reasoning
Authors: Hart Yuval , Mahadevan L. , Dillon Moira R. 
Published: January 2022

AbstractEuclidean geometry has formed the foundation of architecture, science, and technology for millennia, yet the development of human's intuitive reasoning about Euclidean geometry is not well understood. The present study explores the cognitive processes and representations that support the development of humans' intuitive reasoning about Euclidean geometry. One‐hundred‐twenty‐five 7‐ to 12‐year‐old children and 30 adults completed a localization task in which they visually extrapolated missing parts of fragmented planar triangles and a reasoning task in which they answered verbal questions about the general properties of planar triangles. While basic Euclidean principles guided even young children's visual extrapolations, only older children and adults reasoned about triangles in ways that were consistent with Euclidean geometry. Moreover, a relation beteen visual extrapolation and reasoning appeared only in older children and adults. Reasoning consistent with Euclidean geometry may thus emerge when children abandon incorrect, axiomatic‐based reasoning strategies and come to reason using mental simulations of visual extrapolations.
Requirements for human‐induced pluripotent stem cells
Authors: Zhang Ying , Wei Jun , Cao Jiani , Zhang Kehua , Peng Yaojin , Deng Hongkui , Kang Jiuhong , Pan Guangjin , Zhang Yong , Fu Boqiang , Hu Shijun , Na Jie , Liu Yan , Wang Lei , Liang Lingmin , Zhu Huanxin , Zhang Yu , Jin Zi‐Bing , Hao Jie , Ma Aijin , Zhao Tongbiao , Yu Junying 
Published: January 2022

Abstract‘Requirements for Human‐Induced Pluripotent Stem Cells’ is the first set of guidelines on human‐induced pluripotent stem cells in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies the technical requirements, test methods, and instructions for use, labeling, packaging, storage, transportation, and waste handling for human‐induced pluripotent stem cells, which apply to the production and quality control of human‐induced pluripotent stem cells. It was released by the Chinese Society for Cell Biology on 9 January 2021 and came into effect on 9 April 2021. We hope that the publication of these guidelines will promote institutional establishment, acceptance, and execution of proper protocols and accelerate the international standardization of human‐induced pluripotent stem cells for applications.
Homotypic targeting of immunomodulatory nanoparticles for enhanced peripheral and central immunity
Authors: Shen Yubo , Guo Daoxia , Ji Xiaoyuan , Zhou Yanfeng , Liu Shuo , Huang Jing , Song Haiyun 
Published: January 2022

AbstractObjectivesSynthetic oligodeoxynucleotides (ODNs) that contain unmethylated cytosine–phosphate–guanine (CpG) motifs serve as immune adjuvants in disease treatment. However, the poor cell permeability and safety concerns limit their medical applications, and biocompatible strategies for efficient delivery of functional CpG ODNs are highly desirable.Materials and MethodsSelf‐assembled, cell membrane‐coated CpG nanoparticles (NP) are prepared, and their physicochemical properties are characterized. The uncoated and membrane‐coated CpG NP are compared for their biocompatibility, cellular uptake kinetics, endocytic pathways, subcellular localization, and immunostimulatory activities in macrophages and microglia.ResultsMacrophage‐ or microglia‐derived cell membrane camouflaging alters the endocytic pathways of CpG NP, promotes their targeted delivery to the cells with homologous membrane, ensures their endosomal localization, and enhances their immunomodulatory effects.ConclusionsWe design a type of biomimetic NP consisting of self‐assembled CpG NP core and cell membrane shell, and demonstrate its advantages in the modulation of peripheral and central immune cells. Our study provides a new strategy for the application of CpG ODNs.