bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does online investor sentiment explain analyst recommendation changes? Evidence from an emerging market
Authors: Nyakurukwa Kingstone , Seetharam Yudhvir 
Published: June 2022

PurposeThe authors examine how financial analysts respond to online investor sentiment when updating recommendations for specific stocks in South Africa. The aim is to establish whether online sentiment contains significant information that can influence analyst recommendations. The authors follow up the above by examining when online investor sentiment is most associated with analyst recommendation changes.Design/methodology/approachFor online investor sentiment proxies, the authors make use of the social media sentiment and news media sentiment scores provided by Bloomberg Inc. The sample size includes all companies listed on the Johannesburg Stock Exchange All Share Index. The study uses traditional ordinary least squares to examine the relation at the mean and quantile regression to identify the scope of the relationship across the distribution of the dependent variable.FindingsThe authors find evidence that pre-event news sentiment significantly influences analyst recommendation changes while no significant relationship is found with the Twitter sentiment. Further analysis shows that news sentiment is more influential when the recommendation changes are moderate (in the middle of the conditional distribution of the recommendation changes).Originality/valueThe study is the one of the first to examine the association between online sentiment and analyst recommendation changes in an emerging market using high frequency data. The authors also make a direct comparison between social media sentiment and news media sentiment, some of the most used contemporary investor sentiment proxies.
“We do care”: the effects of perceived CSR on employee identification - empirical findings from a developing country
Authors: Roy Taposh 
Published: June 2022

Purpose
Although employees are considered key stakeholders, they receive limited attention in the corporate social responsibility (CSR) literature compared to other stakeholders such as customers. This study aims to address this gap, investigating how different factors, including CSR communication, may affect employee perceptions, and to what extent they can influence or be influenced by CSR activity.

Design/methodology/approach
Semi-structured interviews were used to collect data from three multinationals (MNCs) operating in Bangladesh. Mid- and entry-level employees from different departments, namely, marketing, logistics, human resources, IT and finance, were approached for data collection. It is important to note that all the study participants were Bangladeshi.

Findings
This study demonstrates how CSR perceptions, shaped by the level of employee awareness, personal beliefs about CSR and perceived motivation for adopting CSR, strengthen psychological ties between employees and their organisation. One-way CSR communication adopted by these MNCs disseminates positive information about an organisation’s contribution to society and creates an aspirational and ideational image, which enhances identification, evokes positive in-group biases and encourages employees to defend their organisation against criticism. This study further demonstrates that employee CSR engagement can galvanise their experience of organisational identity, enhance their pride and reinforce their organisational identification.

Originality/value
Drawing on social identity theory and the CSR communication model proposed by Morsing and Schultz (2006), this study aims to understand employees’ CSR perceptions and the possible impact of this on their behaviour. Previous studies largely focus on customers’ perceptions of these activities, which means the link between CSR perception and employee behaviour remains unclear. The current study suggests that employees working in Bangladesh will not withdraw support from their organisations if CSR is used to build reputation or public image. The findings extend the literature by arguing that some employees in developing countries not only seek to improve their status by working in a reputed organisation but also tend to engage with CSR activities undertaken by their organisation.
Forum Introduction: Challenging Orthodoxies: Religion, Secularism and Feminism Among English‐Canadian Women, 1960s–1980s
Authors: Ambrose Linda M. , Block Tina , Marks Lynne 
Published: June 2022

AbstractWhile historians have explored the links between first‐wave feminism and religion, particularly Christianity, in considerable detail in both Canada and the United States, the nature of the relationship between religion, irreligion and second‐wave feminism has received little scholarly attention. This forum explores the complex and troubled intersections between second‐wave feminism, religion and irreligion among Jewish women, both feminist and non‐feminist, a Christian Pentecostal female politician and nonbelieving women.
Public support and advocacy success across the legislative process
Authors: WILLEMS EVELIEN , BEYERS JAN 
Published: June 2022

AbstractThis paper examines how public support affects interest groups’ advocacy success across three distinct stages in the legislative process. We hypothesize that public support is vital for advocacy success when coalition agreements are negotiated, and it has a weaker effect when legislation is introduced in parliament by the governing majority but becomes stronger again when legislation is adopted. We assess these expectations for 55 Belgian policy issues. We combine evidence on legislative outcomes with public opinion data and a mapping of interest groups’ positions in the news. The results indicate that public support is key for advocacy success in the coalition agreement. However, the positive effect of public support weakens when legislation is introduced in parliament – the effect only materializes for initiatives by the opposition – and public support has no significant effect on advocacy success in adopted legislation. Instead, aligning with other groups and political parties becomes more consequential for advocacy success in later legislative stages. Still, on average, interest groups attaining their preferences in adopted legislation enjoy considerable public support. Our results thus underscore the relevance of distinguishing between legislative stages when analyzing interest groups’ advocacy success.
The Power of Numbers: Base‐Ten Threshold Effects in Reported Revenue*
Authors: Stice Derrald , Stice Earl K. , Stice Han , Stice‐Lawrence Lorien 
Published: June 2022

ABSTRACTWe show that managers have a propensity to disproportionately report total revenues just above base‐ten thresholds (e.g., 10 million, 30 million, 1 billion) and examine motives for and consequences of this behavior. Focusing on base‐ten thresholds in revenues is important because, despite being unusually prevalent in revenue targets set in executive compensation contracts, analyst forecasts, and management forecasts, they have not been previously explored. We also show that pressure to beat these targets provides one explanation for the base‐ten bias in reported revenues. However, these incentive effects do not offer a complete explanation because base‐ten threshold‐beating is observed even in the absence of these explicit targets. We further find that when firms beat a base‐ten threshold for the first time, they experience increases in news coverage, institutional ownership, liquidity, and analyst following, even after controlling for whether they have beaten other common benchmarks. These results suggest that managers also beat base‐ten thresholds in order to increase their firms' overall visibility. Overall, we show that a preference for base‐ten numbers, which have no inherent economic meaning, has a measurable effect on the actions of market participants. These results open the door to a new range of managerial targets previously unexplored.
Regulation and roles of RNA modifications in aging‐related diseases
Authors: Jiapaer Zeyidan , Su Dingwen , Hua Lingyang , Lehmann Helge Immo , Gokulnath Priyanka , Vulugundam Gururaja , Song Shannan , Zhang Lingying , Gong Ye , Li Guoping 
Published: June 2022

AbstractWith the aging of the global population, accumulating interest is focused on manipulating the fundamental aging‐related signaling pathways to delay the physiological aging process and eventually slow or prevent the appearance or severity of multiple aging‐related diseases. Recently, emerging evidence has shown that RNA modifications, which were historically considered infrastructural features of cellular RNAs, are dynamically regulated across most of the RNA species in cells and thereby critically involved in major biological processes, including cellular senescence and aging. In this review, we summarize the current knowledge about RNA modifications and provide a catalog of RNA modifications on different RNA species, including mRNAs, miRNAs, lncRNA, tRNAs, and rRNAs. Most importantly, we focus on the regulation and roles of these RNA modifications in aging‐related diseases, including neurodegenerative diseases, cardiovascular diseases, cataracts, osteoporosis, and fertility decline. This would be an important step toward a better understanding of fundamental aging mechanisms and thereby facilitating the development of novel diagnostics and therapeutics for aging‐related diseases.
Effects of prenatal alcohol and delta‐9‐tetrahydrocannabinol exposure via electronic cigarettes on motor development
Authors: Breit Kristen R. , Rodriguez Cristina G. , Lei Annie , Hussain Samirah , Thomas Jennifer D. 
Published: June 2022

AbstractBackgroundPrenatal alcohol exposure can lead to a wide range of neurological and behavioral deficits, including alterations in motor domains. However, much less is known about the effects of prenatal cannabis exposure on motor development, despite cannabis being the most consumed illicit drug among women. Cannabis use among pregnant women has become increasingly popular given the widespread perception that consumption is safe during pregnancy. Moreover, alcohol and cannabis are commonly used together, even among pregnant women. Yet few studies have explored the potential consequences of combined prenatal exposure on behavioral domains.MethodsUsing our previously established model, during gestational days 5 to 20, four groups of pregnant Sprague–Dawley rats were exposed to vaporized alcohol, delta‐9‐Tetrahydrocannabinol (THC) via electronic (e‐) cigarettes, the combination of alcohol and THC, or a vehicle. Following birth, offspring were tested on early sensorimotor development, adolescent motor coordination, and adolescent activity levels.ResultsPrenatal THC e‐cigarette exposure delayed sensorimotor development early in life and impaired motor coordination later in early adolescence; combined prenatal alcohol and THC exposure did not have additive effects on sensorimotor development. However, combined prenatal exposure produced hyperactivity among male offspring.ConclusionsPrenatal cannabis exposure may lead to impaired motor skills throughout early development and combined exposure with alcohol during gestation may lead to hyperactivity in early adolescence. These findings have important implications for informing pregnant women of the risks to the fetus associated with prenatal cannabis exposure, with and without alcohol, and could influence public policy.
Upper thermal tolerances and vulnerability to global warming in a Brazilian Caatinga fishAstyanax bimaculatus (Linnaeus, 1758) population
Authors: Egea‐Serrano Andrés , Alves Maiara C. , Solé Mirco , Tejedo Miguel 
Published: June 2022

AbstractGlobal warming is predicted to increase both average temperatures and the frequency and duration of heat waves. Tropical ectotherms, particularly those living in warm environments are more prone to receive heat impacts. Then, it is crucial to identify those populations already exposed to high temperatures that may be at risk of decimation by ongoing warming. We assessed heating risk in a population of the fish species Astyanax bimaculatus, inhabiting hot pools in intermittent streams in the Brazilian Caatinga ecoregion. We experimentally examined the upper thermal tolerance (CTmax), and provided estimates of warming tolerance (WT), as the difference between CTmax and micro‐environmental peak temperatures (Tmax). Two CTmax estimates ranged between 37.6 and 40.6°C, whereas pond Tmax ranged between 34.6 and 41.3°C. This determines very narrow, even negative WTs, for these extreme heated A. bimaculatus populations, which ultimately may determine their local extinction in the coming decades.Abstract in Portuguese is available with online material.
Attitudes of Australian breast cancer patients toward the secondary use of administrative and clinical trial data
Authors: Hutchings Elizabeth , Butcher Belinda E. , Butow Phyllis , Boyle Frances M. 
Published: June 2022

AbstractAimLittle is known about the attitudes of Australian patients with a history of breast cancer toward the reuse of administrative health data and clinical trial data. Issues of consent, privacy, and information security are key to the discussion. Cancer care and research provides an opportune setting to develop an understanding of attitudes toward data sharing and reuse in individuals with a history of breast cancer.MethodsAn anonymous, online questionnaire for individuals with a history or diagnosis of breast cancer was distributed by two peak bodies (Breast Cancer Trials [BCT] and Breast Cancer Network of Australia [BCNA]) to their memberships between July 14, 2020 and October 17, 2020. Results were captured in RedCap; data analysis was undertaken using Stata, and a thematic analysis of free text responses was undertaken using NVivo.ResultsOne hundred and thirty‐two complete responses were received. Twenty‐three percent of respondents had participated in a clinical trial, and 12% were currently receiving treatment (chemotherapy, radiotherapy, surgery, or endocrine). Respondents were supportive of the secondary use of de‐identified administrative health data and clinical trial data, but showed concern about data security and privacy. Respondents emphasized that the reuse of data should be for improved societal health outcomes, not profit. Many assumed secondary analysis was already undertaken on de‐identified administrative health data and clinical trial data.ConclusionsRespondents were supportive of the secondary use of de‐identified administrative health and clinal trial data within the established bounds of good clinical practice and ethical oversight.
Preoperative leukocytosis is an independent risk factor for morbidity and survival after resection of colorectal liver metastases
Authors: Schnitzler Laura Julie , Oldhafer Felix , Kulik Ulf , Klempnauer Jürgen , Reese Tim , Oldhafer Karl J. , Beetz Oliver 
Published: June 2022

AbstractBackgroundAlthough surgical resection of colorectal liver metastases (CRLM) remains to be the only option for long term survival, traditional surgical concepts have been challenged by the introduction of the liver first approach or neoadjuvant chemotherapy in resectable CRLM and interventional therapies. The aim of this study was to identify prognostic factors for postoperative morbidity and survival and to externally evaluate the recently introduced resection severity index (RSI), in order to optimize patient selection and treatment strategies.MethodsThis is a retrospective single centre analysis of 213 patients undergoing surgery for CRLM in curative intent between January 2010 and December 2018.ResultsMedian follow up after liver resection was 28.56 (0.01–111.46) months. Severe postoperative complications (Clavien‐Dindo ≥ IIIa) were observed in 46 (21.6%) cases. Preoperative leukocytosis (OR: 3.114, CI‐95%: 1.089–8.901; p = 0.034) and operation time in minutes (OR: 1.007, CI‐95%: 1.002–1.011; p = 0.002) were determined as independent risk factors.Overall survival (OS) was 46.68 months with a 5‐year survival rate of 40.5%. Independent prognostic factors were preoperative leukocytosis (HR: 2.358, CI‐95%: 1.170–4.752; p = 0.016), major hepatectomy (HR: 1.741, CI‐95%: 1.098–2.759; p = 0.018) and low grading of the primary intestinal tumour (HR: 0.392, CI‐95%: 0.231–0.667; p < 0.001). The RSI (ASAT (U/l) divided by Quick (%) multiplied by the extent of liver resection in points) was identified as independent risk factor for OS only in patients without neoadjuvant chemotherapy.ConclusionsDetection of leukocytosis in patients prior resection of CRLM was associated with increased postoperative morbidity and decreased OS and could therefore prove valuable for perioperative risk stratification.
Acute limb ischemia after femoro‐femoral extracorporeal life support implantation: A comparison of surgical, percutaneous, or combined vascular access in 402 patients
Authors: Wilhelm Markus J. , Inderbitzin Devdas Thomas , Malorgio Amos , Aser Raed , Gülmez Gökhan , Aigner Tobias , Vogt Paul Robert , Reser Diana 
Published: June 2022

AbstractBackgroundExtracorporeal life support (ECLS) is a salvage treatment for acute circulatory failure. Our high‐volume tertiary centre performs more than 100 implants annually and provides ECLS‐transports. With this study, we aimed to analyze the incidence and risk factors of limb ischemia depending on the vascular access.MethodsBetween January 1, 2007, and December 31, 2018, 937 patients received an ECLS. Preoperative, intraoperative, in‐hospital and up to 5 years follow‐up data were collected. Outcome measures were limb ischemia and survival.ResultsIn total, 402 femoro‐femoral veno‐arterial ECLS patients were identified. Mean age was 56 ± 16.7 years, 26.9% were female, 7.9% had a history of peripheral vascular disease. Cannulation was performed percutaneously in 82.1% (n = 330), surgically in 5.7% (n = 23) and combined in 12.2% (n = 49). Mortality was not significantly different between the groups (51.1% percutaneous, 43.5% surgical, 44.9% combined [p = 0.89]). There was no significant difference in limb ischemia either, but a trend toward an increased frequency in the percutaneous group (p = 0.0501). No amputation was necessary. Limb ischemia slightly increased in‐hospital mortality (54.6%) but did not affect long‐term survival beyond 30 days. Univariate analysis adjusted for cannulation methods revealed younger age and female gender as risk factors of limb ischemia and younger age for limb ischemia after percutaneous cannulation.ConclusionsOur study shows that percutaneous, surgical, and combined vascular access techniques for ECLS implantation are associated with comparable and low incidence of limb ischemia which slightly increases in‐hospital mortality. Special precaution has to be taken in young and female patients.
Qualitative interviewing in the field of work and organisational psychology: Benefits, challenges and guidelines for researchers and reviewers
Authors: Dunwoodie Karen , Macaulay Luke , Newman Alexander 
Published: June 2022

AbstractEmpirical research in the field of work and organisational psychology has typically adopted quantitative methods such as surveys or experiments. Comparatively less research has adopted qualitative methods such as interviewing. The aim and purpose of this article is to provide a practical guide for work and organisational psychology researchers, especially those more familiar with quantitative methods, to get started with qualitative interview approaches. The authors decided to focus on qualitative interviews as they are the most common method adopted in qualitative work and are often combined with other qualitative techniques such as participant observation or quantitative techniques such as surveys or experiments. This article looks at the strengths of adopting a qualitative interview design when conducting empirical research in the fields of work and organisational psychology, and the challenges faced in publishing such research. Finally, the article provides researchers and reviewers with guidelines for effectively executing, publishing and evaluating research adopting a qualitative interview design, and highlights exemplary articles in top journals that adopt qualitative interview designs.
Hippo pathway monomerizes STAT3 to regulate prostate cancer growth
Authors: Tang Qingfeng , Fang Jing , Lai Weiqi , Hu Yu , Liu Chengwan , Hu Xiaobo , Song Caiyong , Cheng Tianmu , Liu Rui , Huang Xiaoke 
Published: June 2022

AbstractProstate cancer ranks among the most commonly diagnosed malignancies for men and has become a non‐negligible threat for public health. Interplay between inflammatory factors and cancer cells renders inflammatory tissue environment as a predisposing condition for cancer development. The Hippo pathway is a conserved signaling pathway across multiple species during evolution that regulates tissue homeostasis and organ development. Nevertheless, whether Hippo pathway regulates cancer‐related inflammatory factors remains elusive. Here, we show that high cell density–mediated activation of the Hippo pathway blunts STAT3 activity in prostate cancer cells. Hippo pathway component MST2 kinase phosphorylates STAT3 at T622, which is located in the SH2 domain of STAT3. This phosphorylation blocks the SH2 domain in one STAT3 molecule to bind with the phosphorylated Y705 site in another STAT3 molecule, which further counteracts IL6‐induced STAT3 dimerization and activation. Expression of a nonphosphorylatable STAT3 T622A mutant enhances STAT3 activity and IL6 expression at high cell density and promotes tumor growth in a mice xenograft model. Our findings demonstrate that STAT3 is a novel phosphorylation substrate for MST2 and thereby highlight a regulatory cascade underlying the crosstalk between inflammation and the Hippo pathway in prostate cancer cells.
Vascular endothelial growth factor receptor 2 expression and immunotherapy efficacy in non–small cell lung cancer
Authors: Nakahama Kenji , Kaneda Hiroyasu , Osawa Masahiko , Fukui Mitsuru , Izumi Motohiro , Yoshimoto Naoki , Sugimoto Akira , Nagamine Hiroaki , Ogawa Koichi , Matsumoto Yoshiya , Sawa Kenji , Tani Yoko , Mitsuoka Shigeki , Watanabe Tetsuya , Asai Kazuhisa , Kawaguchi Tomoya 
Published: June 2022

AbstractIt is unclear whether tumor vascular endothelial growth factor receptor 2 expression affects the therapeutic efficacy of immune‐checkpoint inhibitors and antiangiogenic agents. This retrospective, multicenter study included patients with advanced non–small cell lung cancer who were treated with immune‐checkpoint inhibitors. We constructed tissue microarrays and performed immunohistochemistry with an anti‐vascular endothelial growth factor receptor 2 antibody. We analyzed immune and tumor cell staining separately in order to determine their correlation with the objective response rate, progression‐free survival, and overall survival in patients receiving immune‐checkpoint inhibitors. Of 364 patients, 37 (10%) expressed vascular endothelial growth factor receptor 2 in immune cells and 165 (45%) in tumor cells. The objective response rate, progression‐free survival, and overall survival were significantly worse in patients treated with immune checkpoint inhibitor monotherapy who expressed vascular endothelial growth factor receptor 2 in immune cells than those who did not (10% vs 30%, p = 0.028; median = 2.2 vs 3.6 months, p = 0.012; median = 7.9 vs 17.0 months, p = 0.049, respectively), while there was no significant difference based on tumor cell expression (24% vs 30%, p = 0.33; median = 3.1 vs 3.5 months, p = 0.55; median = 13.6 vs 16.8 months, p = 0.31). There was no significant difference in overall survival between patients treated with and without antiangiogenic agents in any treatment period based on vascular endothelial growth factor receptor 2 expression. Immune checkpoint inhibitor efficacy was limited in patients expressing vascular endothelial growth factor receptor 2 in immune cells.