bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outpatient parenteral antimicrobial therapy in Germany: a prospective cohort study protocol
Authors: Scholten Nadine , Leisse Charlotte , Brandes Vanessa , Oberröhrmann Charlotte , Ihle Peter , Peter Sophie , Hagemeier Anna , Hellmich Martin , Lindemann Christoph H. , Samel Christina , Pfaff Holger , Lehmann Clara 
Published: November 2022

IntroductionOutpatient parenteral antimicrobial therapy (OPAT) means intravenous administration of antibiotics outside the hospital. The antibiotics are administered at the patient’s home. The advantages are the shortening of the inpatient stay, which means that patients can remain in their familiar environment, the reduction of nosocomial infections as well as the reduction of hospital and therapy costs. Nevertheless, OPAT is rarely performed in Germany, despite its international application. Therefore, systematic data on OPAT are not available in Germany. The project objective is to investigate the medical care using OPAT under medical, epidemiological and economic aspects within the framework of the Cologne Network of Infectious Diseases.Methods and analysisObservational study with mixed-methods approach, qualitative analysis to identify physician-side factors to assess the attitude of general practitioners in Cologne with regard to possible implementation barriers of an OPAT. Longitudinal analysis of an OPAT patient cohort with respect to clinical and patient-relevant outcomes using descriptive and conclusive statistics.Ethics and disseminationThe study has been approved by the Institutional Review Board of the University of Cologne, Germany (19-1284-1). Written informed consent was obtained from all participants. The results will be submitted for publication in a peer-reviewed journal and presented at one or more scientific conferences.Trial registration numberNCT04002453.
Development of a coordinated registry network for pelvic organ prolapse technologies
Authors: Baird Courtney E , Chughtai Bilal , Bradley Catherine S , Kobashi Kathleen , Jung Mary , Sedrakyan Art , Andrews Sharon , Ferriter Ann , Cornelison Terri , Marinac-Dabic Danica 
Published: November 2022

ObjectivesThe accumulation of data through a prospective, multicenter Coordinated Registry Network (CRN) could be a robust and cost-effective way to gather real-world evidence on the performance of pelvic organ prolapse (POP) technologies for device-based and intervention-based studies. To develop the CRN, a group of POP experts consisting of representatives from professional societies, the Food and Drug Administration, academia, industry, and the patient community, was convened to discuss the role and feasibility of the CRN and to identify the core data elements important to assess POP technologies.DesignA Delphi method approach was employed to achieve consensus on a core minimum dataset for the CRN. A series of surveys were sent to the panel and answered by each expert anonymously and individually. Results from the surveys were collected, collated, and analyzed by the study design team from Weill Cornell Medicine. Questions for the next round were based on the analysis process and discussed with group members via conference call. This process was repeated twice over a 6-month time period during which consensus was achieved.ResultsTwenty-one experts participated in the effort and proposed 120 data elements. Participation rates in the first and second round of the Delphi survey were 95.2% and 71.4%, respectively. The working group reached final consensus among responders on 90 data elements capturing relevant general medical and surgical history, procedure and discharge, short-term and long-term follow-up, device factors, and surgery and surgeon factors.ConclusionsThe CRN successfully developed a set of core data elements to support the study of POP technologies through convening an expert panel on POP technologies and using the Delphi method. These standardized data elements have the potential to influence patient and provider decisions about treatments and include important outcomes related to efficacy and safety.
Ancestry,ACKR1and leucopenia in patients with systemic lupus erythematosus
Authors: Chung Cecilia P , Karakoc Gul , Liu Ge , Gamboa Jorge L , Mosley Jonathan D , Cox Nancy J , Stein C Michael , Kawai Vivian 
Published: November 2022

ObjectiveSLE is more prevalent in populations of African (AA) than European ancestry (EA) and leucopenia is common. A homozygous variant inACKR1(rs2814778-CC) is associated with lower white cell counts; the variant is common in AA but not EA populations. We hypothesised that in SLE: (1) leucopenia is more frequent in patients of AA than EA, and (2) theACKR1-CC genotype accounts for the higher frequency of leucopenia in AA patients.MethodsWe performed a retrospective cohort study in patients with SLE at a tertiary care system. Ancestry was defined by genetic principal components. We compared the rate of leucopenia, thrombocytopenia and anaemia between (a) EA and AA patients, and (b)ACKR1-CT/TT and CC genotype in AA patients.ResultsThe cohort included 574 patients of EA and 190 of AA;ACKR1-CC genotype was common in AA (70%) but not EA (0%) patients. Rates of leucopenia for ancestry and genotype were AA 60.0% vs EA 36.8 % (p=1.9E-08); CC 67.7% vs CT/TT 42.1% (p=9.8E-04). The rate of leucopenia did not differ by ancestry comparing EA patients versus AA with CT/TT genotype (p=0.59). Thrombocytopenia (22.2% vs 13.2%, p=0.004) and anaemia (88.4% vs 66.2%, p=3.7E-09) were more frequent in AA patients but were not associated withACKR1genotype (p=0.82 and p=0.84, respectively).ConclusionsSLE of AA had higher rates of anaemia, leucopenia, and thrombocytopenia than those of EA; only the difference in leucopenia was explained byACKR1-CC genotype. This genotype could affect clinical practice.
Does recovery from submaximal exercise predict response to cardiac resynchronisation therapy?
Authors: Wouters Philippe , Schoots Thijs , Niemeijer Victor , Spee Ruud F , Kemps Hareld 
Published: November 2022

BackgroundExercise parameters are not routinely incorporated in decision making for cardiac resynchronisation therapy (CRT). Submaximal exercise parameters better reflect daily functional capacity of heart failure patients than parameters measured at maximal exertion, and may therefore better predict response to CRT. We compared various exercise parameters, and sought to establish which best predict CRT response.MethodsIn 31 patients with chronic heart failure (61% male; age 68±7 years), submaximal and maximal cycling testing was performed before and 3 months after CRT. Submaximal oxygen onset (τVO2onset) and recovery kinetics (τVO2recovery), peak oxygen uptake (VO2peak) and oxygen uptake efficiency slope (OUES) where measured. Response was defined as ≥15% relative reduction in end-systolic volume.ResultsAfter controlling for age, New York Heart Association and VO2peak, fast submaximal VO2kinetics were significantly associated with response to CRT, measured either during onset or recovery of submaximal exercise (area under the curve, AUC=0.719 for both; p<0.05). By contrast, VO2peak (AUC=0.632; p=0.199) and OUES (AUC=0.577; p=0.469) were not associated with response. Among patients with fast onset and recovery kinetics, below 60 s, a significantly higher percentage of responders was observed (91% and 92% vs 43% and 40%, respectively).ConclusionsImpaired VO2kinetics may serve as an objective marker of submaximal exercise capacity that is age-independently associated with non-response following CRT, whereas maximal exercise parameters are not. Assessment of VO2kinetics is feasible and easy to perform, but larger studies should confirm their clinical utility.
Defect and degree of the Alexander polynomial
Authors: Lanina E. , Morozov A. 
Published: November 2022

AbstractDefect characterizes the depth of factorization of terms in differential (cyclotomic) expansions of knot polynomials, i.e. of the non-perturbative Wilson averages in the Chern-Simons theory. We prove the conjecture that the defect can be alternatively described as the degree in $$q^{\pm 2}$$

q

±
2

of the fundamental Alexander polynomial, which formally corresponds to the case of no colors. We also pose a question if these Alexander polynomials can be arbitrary integer polynomials of a given degree. A first attempt to answer the latter question is a preliminary analysis of antiparallel descendants of the 2-strand torus knots, which provide a nice set of examples for all values of the defect. The answer turns out to be positive in the case of defect zero knots, what can be observed already in the case of twist knots. This proved conjecture also allows us to provide a complete set of C-polynomials for the symmetrically colored Alexander polynomials for defect zero. In this case, we achieve a complete separation of representation and knot variables.
Modal Characteristic and Nonlinear Dynamic Response of Suspension Bridge with Lateral Asymmetric Stiffness
Authors: Hui Yi , Xia Chao , Li Ke , Qin Jingwei , Xu Liang 
Published: November 2022

Asymmetric stiffness in transverse direction of suspension bridge can be easily induced by many causes during its long-term service. Such phenomenon may cause the coupling effect between vertical and torsional vibrations. A cross-section model of suspension bridge with seven-degree of freedom is proposed, to investigate the asymmetry effect on the dynamic behavior of the system. Corresponding modal analysis is firstly carried out. Results show that the asymmetric stiffness will induce veering phenomenon when natural frequency loci of vertical and torsional modes approach each other. In the veering region, mode hybridization phenomenon can be observed between these two modes. In addition, asymmetry-induced nonlinear vibration of hybrid vertical and torsional modes is studied using the extended incremental harmonic balance method. The effect of asymmetry extent is also investigated in this study. Results show that both hybrid modes can be excited by either the vertical or torsional excitation. Moreover, the energy can be transferred between these two modes, because of the nonlinear stiffness introduced by the significant swaying motion of hanger and cable.
Characteristics and Outcome of Patients With a History of Cancer Undergoing Durable Left Ventricular Assist Device Implantation
Authors: Tie Hongtao , Zhu Jing , Akin Sakir , Allen Larry A. , Huang Bi , Martens Sabrina , Welp Henryk , Simpkin Andrew , Shi Rui , Wu Qingchen , Soliman Osama , Caliskan Kadir , Chen Dan 
Published: November 2022

Background:
Patients with cancer (patients with a history of cancer) with advanced heart failure are increasing, but unlikely to be transplanted, and left ventricular assist device (LVAD) is an alternative strategy. This study investigates the characteristics and outcomes of patients with cancer undergoing durable LVAD.

Methods:
Adult patients with a history of cancer who received LVADs were identified from INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) registry: 2008 and 2017. Characteristics and outcomes between patients with cancer and those without cancer were compared, and subgroup analyses of cancer therapy–induced cardiomyopathy (CCM) and non-CCM were also conducted.

Results:

Overall, 1273 (6.5%) patients had a history of cancer, including 289 (22.7%) with CCM and 984 (77.3%) with non-CCM as the primary reason for heart failure. Patients with cancer had shorter median survival (3.72 versus 3.97 years, log-rank
P
=0.002), and multivariable Cox and competing risk regressions revealed that a history of cancer was associated with reduced survival (hazard ratio, 1.14 [95% CI, 1.04–1.26];
P
=0.005; subdistribution hazard ratio, 1.24 [95% CI, 1.13–1.36];
P<
0.001) and decreased incidence of heart transplantation. There was no significant difference in mortality between patients with CCM-induced heart failure and patients without cancer. Patients with cancer experienced an increased risk of bleeding, and age, INTERMACS profile, albumin, dialysis, and blood urea nitrogen were associated with mortality in these patients.

Conclusions:
A history of cancer is associated with mildly reduced survival, lower incidence of heart transplantation, and increased risk of bleeding after LVAD, whereas the survival in patients with cancer with CCM-induced heart failure is similar to those without cancer. LVAD implantation in patients with cancer is very well possible.
Predatory publishing in Scopus: Evidence on cross-country differences
Authors: Macháček Vít , Srholec Martin 
Published: November 2022

Abstract
Predatory publishing represents a major challenge to scholarly communication. This paper maps the infiltration of journals suspected of predatory practices into the citation database Scopus and examines cross-country differences in the propensity of scholars to publish in such journals. Using the names of “potential, possible, or probable” predatory journals and publishers on Beall’s lists, we derived the ISSNs of 3,293 journals from Ulrichsweb and searched Scopus with them. A total of 324 of journals that appear in both Beall’s lists and Scopus, with 164,000 articles published during 2015–2017 were identified. Analysis of data for 172 countries in four fields of research indicates that there is a remarkable heterogeneity. In the most affected countries, including Kazakhstan and Indonesia, around 17% of articles were published in the suspected predatory journals, while some other countries have no articles in this category whatsoever. Countries with large research sectors at the medium level of economic development, especially in Asia and North Africa, tend to be most susceptible to predatory publishing. Policy makers and stakeholders in these and other developing countries need to pay more attention to the quality of research evaluation.
Using the Sociology of Literature as a Method to Understand Japanese Culture: The Case Study ofBotchanby Natsume Sōseki
Authors: Erdemir Ali Volkan 
Published: November 2022

AbstractThis paper does not attempt to breathe a new life into the sociology of literature. The real concern here is limited to making a possible contribution to the work conducted in Japanese language and literature departments by using the sociology of literature as a method. The discussion begins with a summary of the sociology of literature, merely to make clear the basic characteristics of the method developed by well-known intellectuals. Then the novelBotchanis taken as an example for the suggested approach.
Changes in Opioid Prescription Rates at Discharge After Targeted Provider Education in the Emergency Department
Authors: Booth Deborah , Amalfitano Christopher , Forestine Anthony 
Published: November 2022

Introduction: Opioid-related mortality continues to increase in the United States and emergency departments (ED) are a source of opioid prescribing. A review was conducted of prescribing practices and all prescribers were given targeted education to modify prescribing patterns and facilitate guideline recommended opioid prescribing. This study seeks to evaluate prescribing practices after implementation of the education that occurred December 23 to 31, 2019 on prescribing habits. The pre-education group was defined as the period of January 1, 2019 to December 31, 2019. The post-education group was defined as the period of January 1, 2020 to December 31, 2020. Objective: Evaluate the total number of prescriptions and prescription doses in morphine milligram equivalent (MME) prescribed between pre-education and post-education groups. Secondary endpoints will be an evaluation of the number of doses, length of therapy, and the rates of prescribing per 100 discharges. Methods: A retrospective chart review at a single center suburban ED was conducted comparing prescribing after education was provided. Patients were excluded if they were under the age of 18 years, admitted or transferred to an acute care facility, or prescribed an opioid for a non-analgesic purpose. Results: There was a 34% reduction in the total number of opioid prescriptions from the pre-education group compared to the post-education group (4,253 to 2,818). Between the 2 groups, there was a reduction in MME of 8.8 (92.2 ± 60.4 vs 83.4 ± 60), P < 0.001, number of tablets by 0.9 tablets (13.6 ± 5.2 vs 12.7 ± 5.4), P < 0.001, and day supply by 0.12 (4.45 ± 2.1 vs 4.33 ± 2.0), P = 0.017. Percentage of the total number of opioid prescriptions per 100 discharges decreased by 0.4% from 5.1% to 4.7%. Conclusion: After targeting providers through education, a reduction in opioid prescribing was identified through all endpoints.
Real-time railway plane alignment discrimination based on linear discriminant analysis of Lp norm with sparsity constraint
Authors: Du Xinyu , Qin Zhe , Zhang Yi , Li Ying , Wang Hao 
Published: November 2022

To improve the accuracy of detected parameters at curves by an in-use track geometry measurement (TGM) system, a real-time railway plane alignment (RPA) discrimination method based on linear discriminant analysis of an Lp norm with sparsity constraint (LDA-Lp-SC) is proposed. A standard database to identify the radius of a track curve is established, using the relevant ledger and track TGM data. Multi-dimensional feature extraction is performed on the TGM data, and the parameters of the method are optimized to improve the accuracy of the model classification. Finally, the method is embedded in a TGM system combined with the original RPA discrimination method, so that the key parameters of RPA discrimination can be automatically switched in real time according to the classification result of the track curve radius. Compared with the original method, the method in this study greatly improves the recognition accuracy of track curve with a radius in the range of 150–20,000 m, while ensuring real-time performance.
Estimation of acoustic transmission loss for carbon honey comb panel with melamine foam
Authors: Zai Behzad A , Sami Saad , Waseem Muhammad , Rehman Tanzeel Ur 
Published: November 2022

In this paper, the acoustic noise reduction of aluminum honeycomb/carbon face sheet sandwich panel with Melamine Foam (MF) lining of variable thicknesses (25 mm & 50 mm) is numerically estimated and then experimentally verified using impedance tube based on transfer matrix method. The presence of carbon face sheets and MF lining can have a significant impact on the Transmission Loss (TL). The impedance tube can measure the TL for frequency range of 64 Hz–6.2 kHz. A conventional, two-microphone impedance tube, is connected to a sample holder downstream of the first microphone pair and a section downstream of the sample holder that accommodates a second pair of microphones. The Finite Element Analysis and experimental results are compared and found in good agreements. The TL levels for each layer of material is estimated prior to have TL for combined structure. Furthermore, the optimized insulation foam thickness of 50 mm is obtained based on required acoustic parameters.
A review on deep learning based condition monitoring and fault diagnosis of rotating machinery
Authors: Gangsar Purushottam , Bajpei Aditya Raj , Porwal Rajkumar 
Published: November 2022

Rotating machine faults are unavoidable; thus, early diagnosis is essential to avoid further damage to the machine or other machine attached to it. Various signal analysis based conventional techniques have been developed and used in the industries to identify various defects in the rotating machines. In last two decades, researchers have shifted their focus to automated or intelligent fault diagnosis based on Artificial Intelligence (AI) techniques due to a variety of issues in conventional fault analysis techniques, such as a dependence on machine operating circumstances, human interference, and expert abilities. In AI based techniques, various machine learning (ML) and deep learning (DL) techniques have been successfully applied for fault diagnosis of various rotating machines. From last half decade DL have been gaining popularity due to its attractive characteristic of automated feature learning and solving big data, unbalanced data, big computational burden and over-fitting problems of conventional ML techniques. Advances in DL methodologies have prompted interest in DL based intelligent fault diagnosis in the industry in the last five to 6 years. This review paper summarizes recent research and developments on DL based fault diagnosis in the last five to 6 years for various critical rotating machineries in industry such as electric motors, rotor-bearing systems, gear and gearbox, wind turbines, pumps, and compressors.
A Playful Approach to Household Sustainability: Results From a Pilot Study on Resource Consumption
Authors: Agusdinata Datu Buyung , Lukosch Heide , Hanif Muhammad , Watkins David 
Published: November 2022

Background. U.S. households produce a significant amount of greenhouse gas emissions, indicating a potential to reduce their carbon footprints from changing food, energy, and water (FEW) consumption patterns. Behavioral change to FEW consumption is needed, but difficult to achieve. Interactive and engaging approaches like serious games could be a way to increase awareness of possible measures, leading to more sustainable behavior at a household level. This study looks into the experiences and effects of a digital game for homeowners with the potential to reduce FEW resource consumption impacts. Intervention. In this study, we developed and implemented a digital game to explore its potential to raise awareness of the consumption and conservation of FEW resources and the efficacy of conservation messages. This study aims to measure learning outcomes from game participation and to assess the suitability of the game for informing resource conservation actions. Methods. We tested a proof-of-concept of a digital four-player game, called HomeRUN, with 28 homeowners. The data collected include homeowners’ values and preferences with regard to FEW resources. The patterns of game actions are analyzed with an emphasis on the effectiveness of conservation messaging in informing household consumption behavior. Results. About 65% of the respondents agree that they gained a better understanding of the greenhouse gas emission impacts of FEW resource consumption after playing the game. Over 57% of the respondents agree that the game experience would influence their future consumption behavior, while a quarter of the respondents are unsure. Overall, we demonstrate the HomeRUN game has potential as a tool for informing conservation efforts at a household level.
The Prevalence and Treatment of ADHD in Spain: A Retrospective Cohort Analysis
Authors: Ramos-Quiroga Jose Antonio , Richarte Vanesa , Soto Isabel , Targhetta Maria , Ward John , Perulero Núria 
Published: November 2022

Objective: Estimate the prevalence and incidence of Attention Deficit Hyperactivity Disorder (ADHD) and analyze variations in its treatment across Spain. Method: Analyses were performed using IQVIA’s clinical practice RealWorld Database, the electronic medical records of some 1 million patients from 2013 to 2018. MPH treatment was assessed using the Defined Daily Dose (DDD), MPH sales were extracted from IQVIA’s Sell-Out database and the number of active psychiatrists from IQVIA’s OneKey Database. Results: Significantly higher ADHD prevalence and incidence (1) in children than in adults and (2) in males compared to females. 91% of patients take MPH. Regional variations in MPH consumption range from 247 Daily Dose per Inhabitant (DDI) per 100,000 inhabitants to 414. Conclusion: ADHD continues to be underdiagnosed and undertreated, particularly in adults, and more so in females. The lack of diagnostic tools for adults and the variations in treatment across the country need to be addressed.