bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosing predated tags in telemetry survival studies of migratory fishes in river systems
Authors: Buchanan Rebecca A. , Whitlock Steven L. 
Published: April 2022

Abstract
Background
Acoustic telemetry is a powerful tool for studying fish behavior and survival that relies on the assumption that tag detection reflects the presence of live study subjects. This assumption is violated when tag signals continue to be recorded after consumption by predators. When such tag predation is possible, it is necessary for researchers to diagnose and remove these non-representative detections. Past studies have employed a variety of data-filtering techniques to address the issue, ranging from rule-based algorithms that rely on expert judgements of behavior and movement capabilities of study subjects and their predators to automated pattern-recognition techniques using multivariate analyses. We compare four approaches for flagging suspicious tracks or detection events: two rule-based expert-opinion approaches of differing complexity and two unsupervised pattern-recognition approaches with and without data from deliberately tagged predators. We compare alternative approaches by applying these four filters to a case study of survival estimation of acoustic-tagged juvenile Chinook salmon (Oncorhynchus tshawytscha) in the San Joaquin River, California, United States.

Results
Filtering approaches differed in the number and composition of tags suspected of being consumed by predators; the largest differences occurred between the two broad categories, rule-based versus pattern recognition. All methods required some investigator judgement and all flagged a small subset (5%) of suspicious tags that had exceptionally long residence times and evidence of upstream transitions; 27% of tags showed evidence of predation based on at least one filter. The complex rule-based filter deemed the most tags suspicious (21%) and the simpler pattern-recognition method the fewest (10%). Reach-specific survival estimates from the four filters were mostly within 2% of the unfiltered estimates, but differences up to 11% were observed.

Conclusions
Sensitivity of survival results to tag predation and predator filtering depends on the study setting, spatiotemporal scale of inference, and habitat use of predators. Choice of filtering technique depends on the data available and knowledge of the study system. We recommend that survival studies include clear documentation of filtering methods and report on robustness of results to the filtering approach selected.
Omega-3 fatty acids in bipolar patients with a low omega-3 index and reduced heart rate variability: the “BIPO-3” trial
Authors: Berger Michael , Seemüller Florian , Voggt Alessandra , Obermeier Michael , Kirchberg Franca , Löw Anja , Riedel Michael , von Schacky Clemens , Severus Emanuel 
Published: April 2022

Abstract
Background
Research suggests that a low omega-3 index may contribute to the low heart rate variability and the increased risk of cardiovascular morbidity and mortality in bipolar disorders. However, so far, no intervention trial with EPA and DHA has been conducted in bipolar patients attempting to increase their heart rate variability.

Methods
119 patients with bipolar disorder according to DSM-IV were screened, with 55 euthymic bipolar patients—owing to inclusion criteria (e.g. low omega-3 index (< 6%), SDNN < 60 ms.)—being enrolled in a randomized, double-blind, 12-week parallel study design with omega-3 fatty acids (4 capsules of 530 mg EPA, 150 mg DHA) or corn oil as a placebo, in addition to usual treatment. Heart rate variability as well as the omega-3 index were measured at baseline and at the endpoint of the study.

Results
A total of 42 patients (omega-3: n = 23, corn oil: n = 19) successfully completed the study after 12 weeks. There was a significant increase in the omega-3 index (value at endpoint minus value at baseline) in the omega-3 group compared to the corn oil group (p < 0.0001). However, there was no significant difference in the change of the SDNN (value at endpoint minus value at baseline) between the treatment groups (p = 0.22). In addition, no correlation between changes in SDNN and change in the omega-3 index could be detected in the omega-3 group (correlation coefficient = 0.02, p = 0.94) or the corn oil group (correlation coefficient =  − 0.11, p = 0.91). Similarly, no significant differences between corn oil and omega-3 group regarding the change of LF (p = 0.19), HF (p = 0.34) and LF/HF ratio (p = 0.84) could be demonstrated.

Conclusions
In our randomized, controlled intervention trial in euthymic bipolar patients with a low omega-3 index and reduced heart rate variability no significant effect of omega-3 fatty acids on SDNN or frequency-domain measures HF, LF and LF/HF ratio could be detected. Possible reasons include, among others, the effect of psychotropic medication present in our trial and/or the genetics of bipolar disorder itself. Further research is needed to test these hypotheses.
Trial registration ClinicalTrials.gov, NCT00891826. Registered 01 May 2009–Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT00891826
Evaluation of beliefs and attitudes among caregivers of child labor about mental disorders first aid and stigma
Authors: Ghadirian Laleh , Sayarifard Azadeh 
Published: April 2022

Abstract
Background
The beliefs and attitudes of caregivers of working children about mental health issues and first aid and their attitudes about the stigma of mental health problems can affect their motivation to seek professional help for affected children. This study aimed to assess the mental health literacy among caregivers of child labor about first aid for mental health and their attitudes about the stigma of mental disorders.

Methods
The Depression Health Literacy Questionnaire has been used in this cross-sectional study. All caregivers of working children who were willing to participate were included in the study. This group is covered by a Non-Governmental Organization (NGO) located in the 17th district of Tehran.

Results
Questionnaires completed by 131 caregivers were analyzed. The average age of the participants was 32.6 (± 7.9) years. Of which 130 (99.2%) were mothers. Amongst, only 37 individuals (28.2%) were confident in their ability to help their children in case of depression symptoms. A majority of participants, 109 (83.2%), believed that asking a depressed child about suicidal ideation was harmful.

Conclusion
According to the findings of this study, the literacy among caregivers of child labor about mental health first aid in our study needs to be improved. There is also a need for educational and community-based programs to reduce the stigma about mental health disorders, including depression.
Estimation of the historical dry deposition of air pollution indoors to the monumental paintings by Edvard Munch in the University Aula, in Oslo, Norway
Authors: Grøntoft Terje , Frøysaker Tine 
Published: April 2022

Abstract
The historical (1835–2020) deposition of major air pollutants (SO2, NOx, O3 and PM2.5) indoors, as represented by the monumental Edvard Munch paintings (c. 220 m2) installed in 1916 in the Oslo University Aula in Norway, were approximated from the outdoor air concentrations, indoor to outdoor concentration ratios and dry deposition velocities. The annual deposition of the pollutants to the paintings was found to have been 4–25 times lower than has been reported to buildings outdoors in the urban background in the centre of Oslo. It reflected the outdoor deposition but varied less, from 0.3 to 1.2 g m−2 a−1. The accumulated deposition since 1916, and then not considering the regularly performed cleaning of the paintings, was found to have been 43 ± 13 g m−2, and 110 ± 40 g m−2 in a similar situation since 1835. The ozone deposition, and the PM2.5 deposition before the 1960s, were a relatively larger part of the accumulated total indoor (to the paintings) than reported outdoor deposition. About 18 and 33 times more O3 than NOx and PM2.5 deposition was estimated to the paintings in 2020, as compared to the about similar reported outdoor dry deposition of O3 and NOx. The deposition of PM2.5 to the paintings was probably reduced with about 62% (50–80%) after installation of mechanical filtration in 1975 and was estimated to be 0.011 (± 0.006) g m−2 in 2020.

Graphical Abstract
Physiological and biochemical responses of Chinese cabbage (Brassica rapa var. chinensis) to different light treatments
Authors: Saapilin Nurul Sakinah , Yong Wilson Thau Lym , Cheong Bo Eng , Kamaruzaman Khairul Azfar , Rodrigues Kenneth Francis 
Published: April 2022

Abstract
Background
Artificial agriculture is promoted as an economically viable technology for developing plants under controlled conditions whereby light, water, and fertilizer intake are regulated in a controlled manner to produce maximum productivity with minimal resources. Artificial light has been used to produce high-quality vegetables because it can regulate plant growth and phytochemical production through light intensity, photoperiod, and spectrum modulation. This study aimed to compare the physiological and biochemical responses of Chinese cabbage (Brassica rapa var. chinensis) grown under artificial light with varying light intensities (75 and 150 µmol m−2 s−1), photoperiods (12:12 and 6:6:6:6 h), and wavelengths (blue, red, and magenta) to plants grown in a glasshouse under natural light. The novelty of this study lies in the manipulation of artificial LED lighting to achieve high-quality plant growth and phytochemical composition in B. rapa model vegetables for potential optimal productivity.

Results
The analysis revealed that B. rapa grown under artificial lights produced more consistent biomass yield and had a higher chlorophyll content than B. rapa grown under natural light (control). Plants grown under artificial lights have also been shown to produce biochemical compositions derived primarily from fatty acids, whereas plants grown under natural light have a biochemical composition derived primarily from alkanes. Twenty compounds were found to be statistically different between light treatments out of a total of 31 compounds detected, indicating that they were synthesized in response to specific light conditions. Exposure to the full artificial light spectrum (white) resulted in the absence of compounds such as dodecane and 2,6,10-trimethyltridecane, which were present in B. rapa grown in natural light, whereas exposure to the blue spectrum specifically induced the production of tetracosane. Eicosane, neophytadiene, l-(+)-ascorbic acid 2,6-dihexadecanoate, and (Z,Z,Z)-9,12,15-octadecatrienoic acid were all prevalent compounds produced in B. rapa regardless of light conditions, and their absence may thus affect plant development and survival.

Conclusions
The results show that cultivation under artificial light produced consistent biomass, high chlorophyll content, and phytochemical content comparable to natural light conditions (control). These findings shed light on how artificial light could improve the production efficiency and organoleptic qualities of Chinese cabbage.

Graphical Abstract
Intense pulsed light-based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops
Authors: Martinez-de-la-Casa Jose Maria , Oribio-Quinto Carlos , Milans-del-Bosch Almudena , Perez-Garcia Pilar , Morales-Fernandez Laura , Garcia-Bella Javier , Benitez-del-Castillo Jose Manuel , Garcia-Feijoo Julian , Piñero David P. 
Published: April 2022

Abstract
Background
Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40% to 59% of these patients worldwide. The current study was aimed at evaluating the potential clinical benefit of an intense pulsed light (IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments. To our knowledge, this is the first series analyzing the therapeutic effect of this treatment option in this type of patients.

Methods
This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye symptomatology. All patients received four sessions of IPL treatment using the Optima IPL system (Lumenis, Yokneam, Israel) adjusted to the official optimized Lumenis setting. Changes in symptomatology, corneal staining, conjunctival hyperemia, non-invasive break-up time (NIBUT), tear osmolarity, tear meniscus height (TMH), meiboscore and meibomian gland expressibility was analyzed after treatment.

Results
Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires [ocular surface disease index (OSDI), standard patient evaluation of eye dryness (SPEED) and symptom assessment questionnaire in dry eye (SANDE)] as well as with the visual analogue scale (P < 0.001). Mean change in OSDI was − 15.0 ± 11.3. A significant reduction was found after treatment in the corneal staining score (P < 0.001). A significant reduction was found in tear film meniscus height (P = 0.012), as well as in tear film osmolarity (P = 0.001). A significant reduction was also found in meibomian gland expressibility (P = 0.003), changing the percentage of grade 3 eyes from 44.4% before IPL to 17.2% after treatment.

Conclusions
IPL therapy combined with meibomian gland expression (MGX) seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments, with an additional improvement in clinical signs, such as tear osmolarity and corneal staining.
Anopheles stephensi: a guest to watch in urban Africa
Authors: Kweka Eliningaya J. 
Published: April 2022

AbstractMalaria vector control programs in Sub-Saharan Africa have invested many efforts and resources in the control of eight-sibling species of Anopheles gambiae complex and An. funestus group. The behaviour of sibling species of these vectors is well known and used for implementing the current intervention tools. The reports of An. stephensi in urban Africa with different habitats breeding behaviour is an alert on the success of malaria vector control efforts achieved so far. This communication intends to give an insight on what should be considered as a challenge for the management of An. stephensi in urban Africa to retain the achievement attained in malaria control.
Pulmonary arterial hypertension due to antiphospholipid syndrome initially mimicking chronic thromboembolic pulmonary hypertension
Authors: Yeo Jina , Shin Nami , Ahn Kyung-Jin , Seo Miryoung , Jang Albert Youngwoo , Kim Minsu , Chung Wook-Jin 
Published: April 2022

AbstractPulmonary arterial hypertension (PAH) is the second most common lung complication in antiphospholipid syndrome (APS) patients. However, the concurrent development of APS-related nonthrombotic PAH is rarely reported. Lack of awareness for group 1 PAH in APS patient may contribute to underdiagnosis of this condition. Herein, we reviewed the case of a 56-year-old female who was diagnosed with PAH related to APS that mimicked chronic thromboembolic pulmonary hypertension (CTEPH). It is crucial to be aware of the possibility of a group 1 PAH diagnosis, even though patients have already been diagnosed with CTEPH. Furthermore, a multidisciplinary approach and serial follow-up right heart catheterization with echocardiography are important to make a timely diagnosis and provide optimal treatment for APS-related PAH in patients with CTEPH-like clinical features.
Functional and structural characteristics in patients with diabetic macular oedema after switching from ranibizumab to aflibercept treatment. Three year results in real world settings
Authors: Sepetis Anastasios E. , Clarke Holly , Gupta Bhaskar 
Published: April 2022

Abstract
Background
Our aim was to examine the long term anatomical and functional outcomes in patients with refractory diabetic macular oedema (DMO) undergoing treatment switch from ranibizumab to aflibercept.

Methods
Retrospective review of patients with DMO undergoing treatment switch from ranibizumab to aflibercept at a single centre between 2015 and 2017. Primary outcomes were best corrected visual acuity (BCVA) and central macular thickness (CMT).

Results
57 eyes from 44 patients were included. Following switch to aflibercept, median (IQR) BCVA improved to 73 (64–77) letters at 3 months (p = 0.0006), to 73 (61–78) letters at 6 months (p = 0.0042), to 73 (65–77) at 9 months (p = 0.0006), and to 73 (63–75) letters at 18 months (p = 0.0444). At 36 months following switch, 12 eyes had gained > 10 letters, 5 eyes had gained 5–9 letters, 25 remained stable (± 5 letters), 7 eyes lost 5–9 letters and 8 eyes lost > 10 letters. A significant reduction in CMT at all trimesters following treatment switch was found except at month 24.

Conclusions
We provide real world data suggesting a sustained anatomical and functional benefit of switching from ranibizumab to aflibercept in the treatment of refractory DMO.
Frequency regularization of a linked wind–diesel system using dual structure fuzzy with ultra-capacitor
Authors: Sharma Gulshan , Narayanan K. , Adefarati T. , Sharma Sachin 
Published: April 2022

AbstractMicrogrids (μ-grids) are gaining increased interest around the world for supplying cheap and clean energy. In this paper, a μ-grid comprising a wind turbine generator (WTG) and diesel generator (DG) is considered. It is one of most practical and demanding systems suitable for the present energy crisis in isolated or rural areas. However, wind energy is intermittent in nature while load demand changes frequently. Therefore, a µ-grid can experience large frequency and power fluctuations. The speed governor of the DG tries to minimize the frequency and power deviations in µ-grid though its operation is slow and cannot adequately minimize system deviations. The paper proposes a novel arrangement based on a dual structured fuzzy (DSF) whose structure changes according to the switching limit with a reduced rule base. It has the capability to switch between proportional and integral actions and hence improves the frequency regularization of the μ-grid. The proposed strategy is tested in a μ-grid and the results considering step load alteration, load alteration at different instants of time, nonstop changing load request are compared with some of the well published methods to validate the effectiveness and simplicity of the present design. In addition, it shows that ultra-capacitor establishment in a μ-grid has a positive impact in minimizing system deviations with DSF for the studied cases.
Restricting the construction of second homes in tourist destinations: an effective intervention towards sustainability?
Authors: Stricker Luzius 
Published: April 2022

AbstractThis study evaluates the impact of the second home restriction (Lex Weber) on construction investments in Switzerland. Different specifications and variations are defined, and the changes in investment behaviour are analysed. A first basic model considers the variation in investments through a discrete event study analysis, while a second model includes a continuous treatment variable to account for the different strong impacts of the law in various municipalities. In the second step, these two basic models are developed in a way that allows to include controls for the different cantonal legislation. The results show that with a delay of three years (due to the expiration of permits), the law had the desired impact on new construction investments. Additionally, the importance of the changes on different outcomes in the local economy and tourism industry are discussed.
Effective treatment of refractory complex facial pain with motor cortex stimulation by spinal paddle electrodes using multimodal imaging
Authors: Gong Andrew D. , Gilbert Olivia E. , Mugge Luke A. , Dang Danielle D. , Dang John V. , Awan Omar , Leiphart James W. , Shenai Mahesh B. 
Published: April 2022

Abstract
Background
Complex facial pain is a debilitating condition with varying etiologies that overall responds poorly to both medical and traditional surgical management. Cortical stimulation is a unique therapeutic intervention which can be effective for some types of complex facial pain syndromes (CFPS). However, the novel use of preoperative functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) coupled with intraoperative stimulation mapping and phase reversal to improve the accuracy for placement of spinal paddle electrodes in motor cortex stimulation, to our knowledge, has not been reported in the literature.

Case presentation
Here, we present a unique case of a 56-year-old male who developed left-sided complex facial pain syndrome after a stroke refractory to medical management and peripheral nerve stimulation. He previously underwent microvascular decompression (MVD) with limited control of his left-sided facial pain. In order to treat this, the patient underwent motor cortex stimulation. The motor strip of the face and tongue was identified preoperatively with functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI). Intraoperatively, phase reversal was used to identify corticospinal tracts and stimulus mapping confirmed the location before the epidural placement of two spinal paddle electrodes. Postoperatively, the patient reported significant reduction in pain levels, burning dysesthesias, and intensity and frequency of symptoms. This trend continued, and the patient experienced equivalent levels of relief at 6 months.

Conclusions
This is a rare case report of successful motor cortex stimulation with the novel preoperative use of fMRI and DTI, coupled with intraoperative functional mapping, to successfully guide the placement of spinal paddle electrodes for the treatment of CFPS.
Optogenetics in cardiology: methodology and future applications
Authors: Sung Yen-Ling , Wang Ting-Wei , Lin Ting-Tse , Lin Shien-Fong 
Published: April 2022

AbstractOptogenetics is an emerging biological approach with the unique capability of specific targeting due to the precise light control with high spatial and temporal resolution. It uses selected light wavelengths to control and modulate the biological functions of cells, tissues, and organ levels. Optogenetics has been instrumental in different biomedical applications, including neuroscience, diabetes, and mitochondria, based on distinctive optical biomedical effects with light modulation. Nowadays, optogenetics in cardiology is rapidly evolving for the understanding and treatment of cardiovascular diseases. Several in vitro and in vivo research for cardiac optogenetics demonstrated visible progress. The optogenetics technique can be applied to address critical cardiovascular problems such as heart failure and arrhythmia. To this end, this paper reviews cardiac electrophysiology and the technical progress about experimental and clinical cardiac optogenetics and provides the background and evolution of cardiac optogenetics. We reviewed the literature to demonstrate the servo type, transfection efficiency, signal recording, and heart disease targets in optogenetic applications. Such literature review would hopefully expedite the progress of optogenetics in cardiology and further expect to translate into the clinical terminal in the future.