bluuebunny/crossref_metadata_2025_split huggingface dataset:
Major acute cardiovascular events after dengue infection–A population-based observational study
Authors: Wei Kai-Che , Sy Cheng-Len , Wang Wen-Hwa , Wu Chia-Ling , Chang Shang-Hung , Huang Yu-Tung 
Published: February 2022

Background
Dengue virus (DENV) infection may be associated with increased risks of major adverse cardiovascular effect (MACE), but a large-scale study evaluating the association between DENV infection and MACEs is still lacking.

Methods and findings
All laboratory confirmed dengue cases in Taiwan during 2009 and 2015 were included by CDC notifiable database. The self-controlled case-series design was used to evaluate the association between DENV infection and MACE (including acute myocardial infarction [AMI], heart failure and stroke). The "risk interval" was defined as the first 7 days after the diagnosis of DENV infection and the "control interval" as 1 year before and 1 year after the risk interval. The incidence rate ratio (IRR) and 95% confidence interval (CI) for MACE were estimated by conditional Poisson regression. Finally, the primary outcome of the incidence of MACEs within one year of dengue was observed in 1,247 patients. The IRR of MACEs was 17.9 (95% CI 15.80–20.37) during the first week after the onset of DENV infection observed from 1,244 eligible patients. IRR were significantly higher for hemorrhagic stroke (10.9, 95% CI 6.80–17.49), ischemic stroke (15.56, 95% CI 12.44–19.47), AMI (13.53, 95% CI 10.13–18.06), and heart failure (27.24, 95% CI 22.67–32.73). No increased IRR was observed after day 14.

Conclusions
The risks for MACEs are significantly higher in the immediate time period after dengue infection. Since dengue infection is potentially preventable by early recognition and vaccination, the dengue-associated MACE should be taken into consideration when making public health management policies.
Long-term data on the proposed adalimumab biosimilar BCD-057 in patients with moderate to severe psoriasis: A randomized controlled trial
Authors: Samtsov Alexey V. , Bakulev Andrey L. , Khairutdinov Vladislav R. , Kokhan Muza M. , Korotaeva Tat’yana V. , Minullin Iskander K. , Vylegzhanina Olga A. , Dubenskiy Valery V. , Khalilov Bulat V. , Khotko Alkes A. , Zykova Olga S. , Chumachenko Irina V. , Lukyanov Alexander M. , Artemeva Antonina V. , Pukhtinskaia Polina P. 
Published: February 2022

Introduction
The objective of this study was to demonstrate that BCD-057 is similar to innovator adalimumab (iADA) in terms of efficacy, safety, and pharmacokinetics in steady state in the target population of patients with moderate to severe plaque psoriasis (NCT02762955).

Methods
Patients were randomized in 1:1 ratio to receive 80 mg of BCD-057 or iADA at week 0 and 40 mg thereafter every other week from week 1. At week 24 patients from iADA group were re-randomized (1:1) to continue iADA or to be switched to BCD-057. The primary efficacy endpoint was 75% improvement in Psoriasis Area and Severity Index from baseline (PASI 75), secondary endpoints included PASI percent improvement and relative change in affected Body Surface Area (BSA) from baseline at weeks 16, 24, 33, and 55. Safety was assessed through monitoring of adverse events (AEs) and antidrug antibodies. Pharmacokinetics was evaluated at steady state.

Results
Overall, 346 adult patients were included in the study (174/172 patients in BCD-057/iADA arms, respectively). At week 16 PASI 75 was achieved by 60.34% and 63.37% of patients in BCD-057 and iADA arms, respectively (p = 0.5622). Bounds of the calculated 95% confidence interval (CI) for the difference between PASI 75 responses in arms [-13.26%; 7.2%] fall within the equivalence margin [-15% to 15%] demonstrating equivalent efficacy of BCD-057 and iADA. At week 55 81.61%, 85.56%, and 80.49% of patients in BCD-057, iADA and iADA/BCD-057 arms achieved PASI 75. Comparison of the secondary endpoints did not show significant differences between arms. A comparable pharmacokinetics was shown at steady state. Safety profiles and proportions of patients with antidrug antibodies were similar between arms. The switch from the iADA to BCD-057 did not affect the immunogenicity profile.

Conclusion
Obtained data demonstrate that BCD-057 and iADA are highly similar in clinical efficacy, pharmacokinetics, safety, and immunogenicity in patients with moderate to severe plaque psoriasis.
Key drivers of fertility levels and differentials in India, at the national, state and population subgroup levels, 2015–2016: An application of Bongaarts’ proximate determinants model
Authors: Singh Susheela , Shekhar Chander , Bankole Akinrinola , Acharya Rajib , Audam Suzette , Akinade Temitope 
Published: February 2022

Objectives
The transition to small family size is at an advanced phase in India, with a national TFR of 2.2 in 2015–16. This paper examines the roles of four key determinants of fertility—marriage, contraception, abortion and postpartum infecundability—for India, all 29 states and population subgroups.

Methods
Data from the most recent available national survey, the National Family Health Survey, conducted in 2015–16, were used. The Bongaarts proximate determinants model was used to quantify the roles of the four key factors that largely determine fertility. Methodological contributions of this analysis are: adaptations of the model to the Indian context; measurement of the role of abortion; and provision of estimates for sub-groups nationally and by state: age, education, residence, wealth status and caste.

Results
Nationally, marriage is the most important determinant of the reduction in fertility from the biological maximum, contributing 36%, followed by contraception and abortion, contributing 24% and 23% respectively, and post-partum infecundability contributed 16%. This national pattern of contributions characterizes most states and subgroups. Abortion makes a larger contribution than contraception among young women and better educated women. Findings suggest that sterility and infertility play a greater than average role in Southern states; marriage practices in some Northeastern states; and male migration for less-educated women. The absence of stronger relationships between the key proximate fertility determinants and geography or socio-economic status suggests that as family size declined, the role of these determinants is increasingly homogenous.

Conclusions
Findings argue for improvements across all states and subgroups, in provision of contraceptive care and safe abortion services, given the importance of these mechanisms for implementing fertility preferences. In-depth studies are needed to identify policy and program needs that depend on the barriers and vulnerabilities that exist in specific areas and population groups.
Associations of lymphocyte subpopulations with clinical phenotypes and long-term outcomes in juvenile-onset systemic lupus erythematosus
Authors: Lerkvaleekul Butsabong , Apiwattanakul Nopporn , Tangnararatchakit Kanchana , Jirapattananon Nisa , Srisala Supanart , Vilaiyuk Soamarat 
Published: February 2022

Objective
Juvenile-onset systemic lupus erythematosus (JSLE) is a complex and heterogeneous immune-mediated disease. Cellular components have crucial roles in disease phenotypes and outcomes. We aimed to determine the associations of lymphocyte subsets with clinical manifestations and long-term outcomes in JSLE patients.

Methods
A cohort of 60 JSLE patients provided blood samples during active disease, of whom 34 provided further samples during inactive disease. In a longitudinal study, blood samples were obtained from 49 of the JSLE patients at 0, 3, and 6 months. The healthy control (HC) group consisted of 42 age-matched children. Lymphocyte subsets were analyzed by flow cytometry.

Results
The percentages of CD4+ T, γδ T, and NK cells were significantly decreased in JSLE patients compared with HC, while the percentages of CD8+ T, NKT, and CD19+ B cells were significantly increased. The percentage of regulatory T cells (Tregs) was significantly lower in JSLE patients with lupus nephritis (LN) than in non-LN JSLE patients and HC. The patients were stratified into high and low groups by the median frequency of each lymphocyte subset. The γδ T cells high group and NK cells high group were significantly related to mucosal ulcer. The CD4+ T cells high group was significantly associated with arthritis, and the NKT cells high group was substantially linked with autoimmune hemolytic anemia. The CD8+ T cells low group was mainly related to vasculitis, and the Tregs low group was significantly associated with LN. The percentage of Tregs was significantly increased at 6 months of follow-up, and the LN JSLE group had a lower Treg percentage than the non-LN JSLE group. Predictors of remission on therapy were high Tregs, high absolute lymphocyte count, direct Coombs test positivity, and LN absence at enrollment.

Conclusion
JSLE patients exhibited altered lymphocyte subsets, which were strongly associated with clinical phenotypes and long-term outcomes.
Evaluation of urine sample for diagnosis of visceral leishmaniasis using rK-39 immunochromatographic test in Northwest Ethiopia
Authors: Eyayu Tahir , Yasin Melashu , Workineh Lemma , Tiruneh Tegenaw , Andualem Henok , Sema Meslo , Damtie Shewaneh , Abebaw Aynework , Getie Birhanu , Andargie Desalegn , Achaw Barnabas , Taklual Wubet 
Published: February 2022

Background
Visceral leishmaniasis is the most severe form of leishmaniasis which ranks second in mortality and fourth in morbidity. Parasitological diagnostic techniques with splenic aspirate remain the gold standard. However, sample collection is risky, painful, and difficult. Alternatively, serological techniques provide good diagnostic accuracy using serum sample that is difficult for applying on small children and in the field. So, finding alternative non-invasive and self-collected samples like urine is very important. Thus, the study aimed to evaluate the diagnostic performance of the rK-39 strip test using urine for diagnosis of visceral leishmaniasis.

Methods
A multicenter institutional-based cross-sectional study was conducted from November 2019 to March 2021 at Northwest Ethiopia. Sociodemographic information was collected using a structured questionnaire. Blood sample and midstream urine sample were collected for rK-39 test. Data were entered into Epi-data version 4.2 and analyzed using SPSS version 24.0. Diagnostic performance parameters of urine-based rK-39 rapid test, i.e. sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios (LR+/−), and diagnostic accuracy were determined on contingency table by using serum-based rK-39 test result as a reference. An agreement between urine and serum-based rK-39 test was statistically determined by kappa value.

Result
In total, 300 subjects, age ranged between 7 and 60 years, were included in the study. The overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of urine-based rK-39 test were found to be 98.0% (95% CI: 93.0% - 99.8%), 95.5% (95% CI: 91.6% - 97.9%), 91.6% (95% CI: 85.2%– 95.4%), 98.9 (95% CI: 96.0%– 99.7%), and 96.33% (95% CI: 93.53–98.16%), respectively. Additionally, there was a strong agreement between the results obtained on rK-39 ICT using urine and serum samples (kappa = 0.92; P < 0.001).

Conclusion
Urine-based rK-39 ICT had an excellent high sensitivity, specificity and strong agreement with serum-based rK-39 ICT results. This indicates that urine sample would be a promising noninvasive and easy to collect sample for diagnosis of VL in field and rural settings.
Economic crisis and trauma journalism: Assessing the emotional toll of reporting in crisis-ridden countries
Authors: Papadopoulou Lambrini , Maniou Theodora A. , Pandia Eleana 
Published: February 2022

AbstractThis article discusses the relationship between the post-2008 global economic crisis and trauma journalism through a quantitative study of reporters covering austerity’s everyday manifestations and examines the effects on the media professionals involved. The findings indicate that journalists who cover economic crisis-related incidents suffer specific symptoms of trauma. As such, the study re-conceptualizes the economic crisis as primarily affective for media workers, it establishes a direct correlation between the economic crisis and emotional trauma, and provides an insight into the kind of trauma that stems from covering austerity and its impact on society. A regression analysis of symptoms indicates trauma journalism as an emerging field of research into the economic crisis.
Sonochemical synthesis of protein microcapsules loaded with traditional Chinese herb extracts
Authors: Wang Xin , Wang Zhe , Guo Shengwei , Wang Guxia , Xue Min 
Published: February 2022

Abstract
Traditional Chinese herbs have attracted extensive attention due to their good efficacy, low toxicity, and minor side effects. However, some active ingredient extracts are relatively sensitive to external influence and liable to lose their effectiveness. Different from the traditional and complex encapsulation methods, one can easily prepare drug-loaded microcapsules to improve their bioavailability using the new encapsulation technology. In this work, we used the sonochemical method to prepare bovine serum albumin (BSA)/astragalus membranaceus oil (AM) microcapsules. The technology was simpler, greener, and more efficient. Thereinto, BSA and AM oil were used as the shell material and the core material, respectively. The effects of ultrasonic amplitude, ultrasonic mode, and ultrasonic time on synthetic reactions were studied. The morphology and size of the BSA/AM microcapsules were investigated using transmission electron microscopy, scanning electron microscopy, and dynamic light scattering (DLS). The loading efficiency and drug release behavior were determined using thermogravimetric analysis (TGA) and ultraviolet (UV) spectroscopy, respectively. The best ultrasonic synthesis conditions were obtained by the above analysis, with an ultrasound amplitude of 30%, ultrasound mode of the pulse mode of 2 s, ultrasound time of 4 min. The DLS results show that the microcapsule size is 484.4 nm and the polydispersity index is small. The TGA results show that the drug loading efficiency is about 77%, and the hemolysis tests show that the BSA/AM microcapsules have no cytotoxicity at lower concentrations (lower than 50 μg·mL−1).
Aspects of the physiochemical properties of SARS-CoV-2 to prevent S-protein receptor binding using Arabic gum
Authors: Ghobashy Mohamed Mohamady , Alshangiti Dalal Mohamed , Alkhursani Sheikha A. , Al-Gahtany Samera Ali , Meganid Abeer S. , Madani Mohamed , Kodous Ahmad S. 
Published: February 2022

Abstract
With the number of people infected with the new coronavirus exceeding millions of confirmed infections, the world is turning to scientists and researchers, everyone is waiting – impatiently – for the results of the research that is being carried out in full swing to find an effective treatment for the virus. The recent development of the virus has witnessed at least 17 mutations that may affect its external shape, especially on the S-protein receptor-binding domain (RBD), which helps it attach to human cells’ receptor angiotensin-converting enzyme-2 (ACE2) to make RBD–ACE2 interaction and entry to host cell. This interaction becomes stronger in the new strains of the coronavirus due to a mutation that occurs in the S-proteins that attach to human cells. For researchers and scientists to be able to confront this pandemic that has spread in the world like wildfire, they must be armed with accurate understanding and clear knowledge about coronavirus. This study focuses on polysaccharides, specifically negatively polysaccharides, that can interfere with the positive charge of the surface of the SARS-CoV-2 and ACE2, thus inhibiting the virus’s infectivity and destroying it. In addition, polysaccharides will boost the immune function of the vaccine, thereby fostering nonspecific immunity of the body and specific immunity of the body, cellular immunity, mucosal immunity, humoral immunity, and decreased pro-inflammatory expression. This research aims to reduce the attachment power and modify the pulling apart of the RBD and the angiotensin-converting enzyme 2 (ACE2) by polysaccharide molecules such as Arabic gum (AG) and carrageenan. The adapted fluorometric assay is used to investigate the probability of Arabic gum and ACE2 interactions. The obtained results confirmed that the interaction could take place between Arabic gum and ACE2. Several literature studies promote the use of the urchin egg as antiviral, especially for SARS-CoV-2, because it has sulfated fucan polysaccharide molecules that prevent interaction of SARS-CoV-2 with a host cell. But, to the best of our knowledge, we found that the effect of urchin egg as antiviral, especially for SARS-CoV-2 is very difficult due to the presence of immunoglobulin G (IgG) in the human cells containing sugars that terminate with N-glycolylneuraminic (Neu5Ac) as found in the sperm of sea urchin. So, s most probably an interaction has occurred between Neu5Ac in IgG of human cells and sulfated fucan polysaccharide molecules of urchin egg.
Prediction of the critical conditions for dynamic recrystallization in metals
Authors: Gottstein G. , Brünger E. , Frommert M. , Goerdeler M. , Zeng M. 
Published: February 2022

Abstract
Engineering approaches to model dynamic recrystallization (DRX) explicitly assume the existence of a critical strain for DRX. Since the strain is not a state variable of crystal plasticity, however, there is no critical strain, rather there are critical conditions for microstructural instability. It was proposed recently that these critical conditions can be expressed in terms of a point of inflection on the θ(σ) curve, where σ is the flow stress and θ is the hardening rate. A theoretical framework is presented to predict these critical conditions on the basis of a dislocation work hardening model. Once tuned to a specific hardening curve the model allows to predict the onset of DRX for different temperatures and strain rates, and, in principle, for changing materials chemistry.
Thermodynamic assessment of the Pd–Zr system
Authors: Du Zhenmin 
Published: February 2022

Abstract
The Pd–Zr system has been critically assessed by means of the CALPHAD technique. The solution phases (liquid, body-centered cubic (Zr), face-centered cubic (Pd) and hexagonal close-packed (Zr)) were modeled with the Redlich – Kister equation. The intermetallic compounds Pd3Zr and γPdZr, which have a homogeneity range, were treated as the formulae (Pd, Zr)3(Pd, Zr) and (Pd, Va)(Pd, Zr) by a two-sublattice model with Pd and Zr or Pd and vacancies, denoted Va, on the first sublattice, Pd and Zr on the second one, respectively. Both compounds Pd2Zr and PdZr2 having a tetragonal MoSi2-type structure were treated as one phase with the formula PdZr(Pd, Zr) by a three-sublattice model with Pd on the first sublattice, Zr on the second, and Pd and Zr on the third one, respectively. The others were treated as stoichiometric compounds. A set of self-consistent thermodynamic parameters of the Pd–Zr system was obtained.
The rhetorical neuroscience of style: On the primacy of style elements during literary discourse processing
Authors: Burke Michael 
Published: February 2022

Abstract
Much work has been conducted in the social psychological sciences both modelling and predicting how the storage and retrieval of images and words in the mind operate (e.g. Baddeley 1974, 2000, Damasio 1999, Barsalou 1999). The focus has largely been on the interactions between short-term and long-term regions of memory. Such studies have also on occasion been complemented by behavioural experiments. More recently, a growing body of work has started to emerge from the biological cognitive neurosciences which looks at these same processes with the aid of scanning technologies (e.g. Dehaene 2003, 2009, Ledoux 1998, Eichenbaum 2011). The questions that will be considered in this paper are can these scientific findings be extended to aesthetic objects that are studied in the humanities, and in particular to the style of literary texts, and also can the way literary style figures operate shed light on how the mind and brain might function.
High data-rate two-three inputs all-optical AND gate based on FWM in highly nonlinear fiber
Authors: Sabbar Adnan , Abdulnabi Saif Hasan , Fakhruldeen Hassan Falah 
Published: February 2022

Abstract
In this paper, two-and-three channel all-optical AND logic gates based on four-wave mixing in a highly nonlinear fiber for 120 Gbps on–off keying signals were designed, simulated, and investigated. Simulation results show low bit error rate and consequently fairly high Q-factor at the receiving end in both two and three inputs AND gates, as well as the logic operation, is confirmed by the open eye diagrams with moderate power penalties for both designs.
A 7-year-old boy with central diabetes insipidus presenting with thickened pituitary stalk and anti-rabphilin-3A antibody positivity
Authors: Morota Kazutaka , Tadokoro Hiroaki , Sawano Kentaro , Watanabe Kenichi , Iwata Naoko , Fujisawa Haruki , Suzuki Atsushi , Sugimura Yoshihisa , Nagasaki Keisuke 
Published: February 2022

Abstract

Objectives
A highly invasive pathological diagnosis is necessary to differentiate central diabetes insipidus (CDI) with a thickened pituitary stalk. Lymphocytic infundibulo-hypophysitis (LIH) due to autoimmune involvement of the pituitary stalk is a differentiating disease, and anti-rabphilin-3A antibody (Rab3A-Ab) positivity was recently reported.

Case presentation
A 7-year-old boy was diagnosed with CDI after having polyuria for two months. He showed growth hormone deficiency with reduced growth rate. Brain magnetic resonance imaging (MRI) revealed a thickened pituitary stalk. The placental alkaline phosphatase level of the cerebrospinal fluid, tumor marker for germ cell tumors, was below the level of sensitivity. No skin or bone findings suggestive of Langerhans cell histiocytosis were detected. Eight months after CDI onset, Rab3A-Ab was positive, and MRI showed shrinking of the thickened pituitary stalk, leading to the diagnosis with LIH.

Conclusions
Rab3A-Ab is a useful adjunctive diagnostic tool for childhood-onset LIH.
The pragmatics of surprise-disapproval questions: An empirical study
Authors: Trotzke Andreas , Czypionka Anna 
Published: February 2022

Abstract
In this paper, we investigate a type of non-canonical question that is not information-seeking, but rather expresses the speaker’s surprise and/or disapproval with respect to the event denoted by the propositional part of the question. Our work is empirically based on claims that have been put forward in the syntactic literature, and our study aims at empirically assessing those theoretical claims about the illocutionary status of surprise-disapproval questions by exploring their pragmatics.