bluuebunny/crossref_metadata_2025_split huggingface dataset:
Message from editor
Authors: Ozcinar Assoc. Prof. Dr. Zehra 
Published: December 2022

Message from Editor
Dear Readers,

It is a great honor for us to publish third volume, third issue International Journal of Innovative Research in Education (IJIRE).
International Journal of Innovative Research in Education welcomes original empirical investigations and comprehensive literature review articles. The journal aims to promote new innovative ideas in all fields of education.
The journal provides an international platform for researchers, managers, scientists, professionals and professors of educational sciences to publish high quality refereed papers comprising comprehensive leading trends of education.
Topics on education financing in countries, food consumption among students, activities on knowing our body, key competencies in lifelong learning and gamification are included into this issue. The topics of the next issue will be different. We will be trying to serve you with our journal with a rich knowledge in which different kinds of topics are discussed in the next volume.
A total number of fifteen (15) manuscripts were submitted for this issue and each paper has been subjected to double-blind peer review process by the reviewers specialized in the related field. At the end of the review process, a total number of five (5) high quality research papers were selected and accepted for publication for this issue.
We present many thanks to all the contributors who helped us to publish this issue.

Best regards,
Assoc. Prof. Dr. Zehra Ozcinar
Editor â€“ in Chief
The ontology of resistance between power and knowledge: A philosophical approach
Authors: Al Sheikh Hanan Muneer 
Published: December 2022

The ontology of human resistance accentuates its existence through several expressive means with the most important being art, as art transforms the question of resistance into a self-practice that starts with the artists and transfers between the inside and the outside in a continuous, creative, effective mutual relationship, in order to emphasise the battle of existence conflict, ideology and epistemology within the general framework of power. This philosophic analysis is based on the hypotheses of having a multilateral factor that continues with the past legacy on one hand and interprets the present while overpassing it on the other. This is to create a state of creativity that represents the intellectual, emotional, cognitive and historical inventory while posing a situation of continuous wondering among individuals and groups. This artistic state unifies the indicators of symbolisations and makes resistance represented in a contemporary visual discourse that rejects dominance. It also accentuates the identity and transforms the theoretical intellectual question into a practised anthological act that is featured of permanent activity as a perpetual act towards liberation and reproducing self-existence.

Keywords: Art philosophy, resistance ontology, political caricature, photography.
Micro and nano fat grafting for the treatment of Tessier 3 and 4 craniofacial clefts volume defect: A case series
Authors: Windura Carolus Aldo , Josh Fonny , Soekamto Tomie Hermawan 
Published: December 2022

Background: Patients with craniofacial clefts who have had reconstructive surgery often develop problems, such as contour deformity that will cause psychological issues. Micro and nano fat grafting are various methods utilized to overcome these issues.
Case and Operation Technique: This case series describes two patients with facial contour deformities due to Tessier 3 and 4 craniofacial clefts, respectively. Each patient underwent secondary reconstruction correction surgery followed by a combination of micro and nano fat grafting.
Discussion: Results on day 7 after surgery were promising. Growth factors and stem cells in nano fat complemented the micro fat properties, thus increasing the survivability rate.
Conclusion: This case series demonstrates that the combination of micro and nano fat shows promising results for overcoming facial contour deformity.
The Sediment Budget Estimator (SBE): A process model for the stochastic estimation of fluxes and budgets of sediment through submarine channel systems
Authors: Eggenhuisen Joris T. , Tilston Mike C. , Stevenson Christopher J. , Hubbard Stephen M. , Cartigny Matthieu J.B. , Heijnen Maarten S. , de Leeuw Jan , Pohl Florian , Spychala Yvonne T. 
Published: December 2022

AbstractTurbidity currents transport vast amounts of sediment through submarine channels onto deep-marine basin-floor fans. There is a lack of quantitative tools for the reconstruction of the sediment budget of these systems. The aim of this paper is to construct a simple and user-friendly model that can estimate turbidity-current structure and sediment budget based on observable submarine-channel dimensions and general characteristics of the system of interest. The requirements for the model were defined in the spirit of the source-to-sink perspective of sediment volume modeling: a simple, quantitative model that reflects natural variability and can be applied to ancient systems with sparse data availability. The model uses the input conditions to parameterize analytical formulations for the velocity and concentration profiles of turbidity currents. Channel cross section and temporal punctuation of turbidity-current activity in the channel are used to estimate sediment flux and sediment budget. The inherent uncertainties of geological sediment-budget estimates motivate a stochastic approach, which results in histograms of sediment-budget estimations, rather than discrete values. The model is validated against small-scale experimental turbidity currents and the 1929 Grand Banks turbidity current. The model performs within acceptable margins of error for sediment-flux predictions at these smallest and largest scales of turbidity currents possible on Earth. Finally, the model is applied to reconstruct the sediment budget related to Cretaceous slope-channel deposits (Tres Pasos Formation, Chile). The results give insight into the likely highly stratified concentration profile and the flow velocity of the Cretaceous turbidity currents that formed the deposits. They also yield estimates of the typical volume of sediment transported through the channels while they were active. These volumes are demonstrated to vary greatly depending on the geologic interpretation of the relation between observable deposit geometries and the dimensions of the flows that formed them. Finally, the shape of the probability density functions of predicted sediment budgets is shown to depend on the geological (un)certainty ranges. Correct geological interpretations of deep marine deposits are therefore indispensable for quantifications of sediment budgets in deep marine systems.
Discretion and its Effects: Analyzing the Role of Street-Level Bureaucrats’ Policy Enforcement Style
Authors: Hassan Mohammed Salah , Alhalbusi Hussam , Ahmad Ahmad Bayiz , Abdelfattah Fadi , Thamir Zahraa , Ariffin Raja Noriza Raja 
Published: December 2022

Abstract
This study examines street-level bureaucrats’ discretion as it informs their enforcement style during personal encounters with clients and considers how that style defines bureaucrats’ perceptions of their clients. A conceptual model is developed based on street-level bureaucracy theory and existing implementation literature and is tested using field data collected from a sample of 241 labor inspectors in the Malaysian Department of Labor. Structural Equation Modelling results show that discretion was positively related to client meaningfulness, and the relationship between discretion and client meaningfulness was significantly mediated by the accommodation and facilitation dimensions of enforcement style. The findings are significant as they illuminate street-level bureaucrats’ behavior and perceptions during encounters with clients and confirm that enforcement style is a three-dimensional concept. Moreover, this research argues that the perceptions of bureaucrats toward their clients redefines their behavior during the policy enforcement process and ultimately shapes their encounters with the public. Furthermore, theory and practical implications derived from the findings are discussed.
Regulation of iNOS -NF-kappa B- COX-2 inflammatory pathway by alpha-pinene neuroprotective effects in brain ischemia model
Authors: Erfani Sohaila , Khoshnazar Seyedeh Mahdieh , afzali Fatemeh Ephtekhar , Abdolmaleki Arash , Moghadam Bahram Farhadi 
Published: December 2022

Abstract
Objectives Cerebral ischemia-reperfusion leads to brain tissue injury. Inflammation and apoptosis play pivotal roles in the pathology. α-Pinene is an organic compound of many aromatic plants and is known as a potent agent to possess antioxidant, and anti-inflammatory properties. Here, we sought to identify the anti-inflammatory and anti-apoptosis mechanism by which α-Pinene improves brain ischemia injury.
Methods Male Wistar rats underwent MCAO surgery for 1 hour and different doses of alpha-pinene (25, 50, and 100 mg/kg) were intraperitoneally injected immediately after reperfusion to test this hypothesis. IV, NDS, gene and protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor kappa B (NF-κB) p65, and caspase-3 were assessed 24h after reperfusion.
Key findings Results demonstrated that iNOS, COX2 and NF-KB gene and protein expression increased in the hippocampus, cortex, and striatum after 24 h of reperfusion, and alpha-pinene significantly inhibited iNOS, COX2 and NF-KB expression. Also, alpha-pinene significantly reduced the ischemia/reperfusion-induced caspase-3 activation in CA1 area of hippocampus.
Conclusions Results showed that alpha-pinene protects the cerebral against ischemic damage caused by MCAO, and this effect may be through the regulating iNOS, COX2 and NF-KB and caspas-3 inflammatory and apoptotic pathways.
Molecular characterization and comparisons of potato wart (Synchytrium endobioticum) in historic collections to recent findings in Canada and the Netherlands
Authors: de Vossenberg Bart van , Gent Marga van , Meffert Johan P. , Nguyen Hai D.T. , Smith Donna , Kempen Thijn van , Helderman Carin M. , Rosendahl-Peters Karin C.H.M. , Braak Naomi te , Flath Kerstin , Przetakiewicz Jarosław , Perez Willmer , Çakir Emel , Sikharulidze Zoia V. , Leeuwen Gerard C.M. van , Lee Theo A.J. van der 
Published: December 2022

Abstract
Synchytrium endobioticum (Schilb.) Perc. is a chytrid fungus causing potato wart disease and is one of the most important quarantine diseases on cultivated potato. Infected host tissues develop warts rendering the crop unmarketable. Resting spores that can remain viable and infectious for decades are formed in warted tissues which are released into the surrounding soil when the host tissue decays.
To better understand the pathogen’s diversity and to potentially uncover pathways of migrations and introduction events, molecular characterization was performed on the historical S. endobioticum resting spore collection of the Dutch National Plant Protection Organization. Mitochondrial genomes were assembled and annotated, and four novel structural variants were identified from these materials with intronic presence-absence variation in cox1 or cob genes and structural variation in the dpoB – TIR region. Several fungal isolates were shown to contain mixtures of structural variants.
We analyzed the mitogenomic sequences obtained from recent potato wart disease findings in Canada and the Netherlands in the context of the historical materials and found that fungal isolates from the new Dutch outbreak contained a specific mixture of mitogenomic variants previously not observed in the Netherlands. Based on the mitogenomic profile, pathotype 38(Nevşehir) was suspected which was later verified by pathotyping.
To further facilitate dissemination of data and interactive visual analytics we created a public Nextstrain webpage with S. endobioticum mitogenomic sequences and associated metadata on their geographic origin, pathotype identity and (mixture) of mitogenomic variants ( https://nextstrain.nrcnvwa.nl/Sendo ).
Efficacy and safety of nabufen and sufentanil in the prevention of visceral pain after gynecological laparoscopic surgery:a randomised controlled trial
Authors: gu xiaoxia , Peng Xue , Chen ZhiYuan , Pang Ping , Shao Ruizhao , Hu Kui , Wang Jingjing , Liang Guangbin 
Published: December 2022

Abstract
Background
To compare the efficacy and safety of different compatibility schemes in the prevention of visceral pain after gynecological laparoscopic surgery.
Methods
from April 2019 to April 2020, patients undergoing elective gynecological laparoscopic surgery in our hospital were randomly divided into four groups: group A: sufentanil 3 μ g / kg; group B: low-dose nalbuphine group: 0.1 mg / kg of nabufen + 3 μ g / kg of sufentanil; group C: medium dose of nabufen group: 1 mg / kg of nabufen + 2 μ g / kg of sufentanil; group D: high-dose nabufen 2 There were 30 cases in each group. The degree of pain and the number of adverse reactions at 2, 4, 8, 12, 24 and 48 hours after operation were observed and recorded. The number and dosage of morphine used as a remedial analgesic were recorded. The pain degree was assessed by VAS. The total amount of analgesic pump used, the total number of times of pressing and effective times of pressing were recorded. The adverse reactions also was recorded.
Results
the analgesic effect of group B was similar to that of group A, while the invalid pressing times, total pressing times and remedial analgesia rate of group C and group D were significantly lower than those of group A ( P < 0.05). There was no significant difference between group C and group D in the number of invalid compressions, the total number of compressions and the rate of remedial analgesia ( P > 0.05), suggesting that increasing the dose of nalbuphine could not significantly increase the analgesic effect. The incidence of postoperative nausea and vomiting, skin pruritus, lethargy and Ramsay Sedation score in group B and group C were significantly lower than those in group A ( P < 0.05). Ramsay Sedation score and incidence of drowsiness were lower than those in group D.
Conclusion
the combination of 1 mg / kg nabufen and 2 μ g / kg sufentanil is a safe and effective combination scheme for the prevention of visceral pain after gynecological laparoscopic surgery with small adverse reactions.
Trial registration:
http://www.chictr.org.cn/showproj.aspx?proj=40635
Registration number：ChiCTR1900025076 . Prospectively registered on 10 August 2019.
Trustworthy Deep Learning for Encrypted Traffic Classification
Authors: Li Zheng , Liu Yanbei , Zhang Changqing , Shan Wanjin , Zhang Haifeng , Zhu Xiaoming 
Published: December 2022

Abstract

Network traffic classification refers to the identification of collected network traffic data of various applications, which is widely used in research fields such as network resource allocation, traffic scheduling and intrusion detection systems. With the widespread application of encryption technology in the network, encrypted traffic classification has become a hot research topic. At present, most existing methods only focus on the accuracy of network traffic classification. Yet, few work studies the reliability of the classification model, which plays an important role in network regulation and network security. In this paper, we propose a novel traffic classification method based on trustworthy deep learning model, which can effectively improve the reliability of encrypted traffic classification models by correcting the confidence of model output. Specifically, we firstly perform data preprocessing on the original network traffic, and then adopt a ConvNet for feature learning and a ClassifyNet for traffic classification in the initial stage. At the same time, we utilize a trustworthy confidence criterion to design a ConfidNet trained according to the probability of the true class. The ConfidNet can provide a reliable confidence measure for the prediction of the classification model. Finally, we demonstrate the effectiveness of our framework through comprehensive experiments on two benchmark datasets ISCX VPN-nonVPN and USTC-TFC2016, and show that our method can improve the reliability of the classification model and has a good ability to identify misclassified samples compared with state-of-the-art methods.
The spatio-temporal landscape of the transcriptome and metabolome of cotton fiber cells during their initiation and late development
Authors: Sun Xuwu , Qin Aizhi , Wang Xingxing , Ge Xiao-Yang , Liu Zhixin , Guo Chenxi , Yu Xiaole , Zhang Xianliang , Lu Yao , Yang Jincheng , He Jiuming , Zhou Yaping , Liu Yumeng , Hu Mengke , Liu Hao , Zhao Zihao , Hu Guanjing , Li Wei , Zang Xinshan , Dai Shuai , Sun Susu , Yong-Villalobos Lenin , Herrera-Estrella Luis , Tran Lam-Son Phan , Ma Xiongfeng 
Published: December 2022

Abstract

Cotton fibers develop from epidermal cells in the outer integument of ovules. The regulatory process underlying fiber cell development has been extensively studied, little is known about the spatio-temporal profiles of transcriptomes and metabolomes during its development. Here we characterized the dynamics of transcriptome and metabolome during the early developmental stages of cotton fiber cells using a combination of spatial transcriptomic, single-cell transcriptomic, and spatial metabolomic analyses. We identified the key genetic regulators and metabolites that initiate and determine the fate of fiber cells. Both knockdown and gain-of-function analyses of one new identified marker gene BEE3/Gh_A09G062900 revealed its important role in the initiation of cotton fiber. We also designed a website for the public visualization of spatial gene expression in cotton that provides important reference datasets of spatio-temporal gene expression and can be used to further decipher the genetic and metabolic regulation of cotton fiber development (http://CottonOvule.cricaas.com.cn/).
A protocol for establishing a core outcome set for studies examining treatments for Problematic Internet use
Authors: Wu Liu , Wang Yang , Zhao Xinyu , Zhou Mingze , Gao Ping , Yi Ting , Cui Jiarui , Li Hui , Zhu Tianmin 
Published: December 2022

Abstract
Background
Randomised controlled trials (RCTs) evaluating Problematic internet use (PIU) have reported many different outcomes, which are themselves often defined and measured in distinct ways. Numerous clinical trials have been conducted on the efficacy and safety of different interventions in the treatment of PIU, resulting in many different outcome measures and different ways of measuring them. In order to facilitate the future research of PIU, it is necessary to produce the core Outcome Set (COS), which can help to translate the results into high-quality evidence.
Methods and analysis:
This mixed-method project has a three-phase tool: Phase 1, a scoping review of the literature to identify outcomes that have been reported in clinical trials and systematic reviews of interventions for PIU. Phase 2, a systematic review of PIU literature was conducted to identify potential outcome indicators. Phase 3, final outcome indicators were determined through Modified Delphi Method, Consensus Meetings, Stakeholder Perspectives and Stakeholder Consultations.
Conclusions
We will develop a COS that should be reported in future clinical trials of PIU.
Trial registration:
Core Outcome Measures in Effectiveness Trials (COMET) Initiative database registration: www.comet-initiative.org/Studies/Details/2109. Registered in August 2022.
Facilitating implementation of primary care mental health over time and across organizational contexts: a qualitative study of role and process
Authors: Ritchie Mona J. , Parker Louise E. , Kirchner JoAnn E. 
Published: December 2022

Abstract
Background: Healthcare organizations have increasingly utilized facilitation to improve implementation of evidence-based practices and programs (e.g., primary care mental health integration). Facilitation is both a role, related to the purpose of facilitation, and a process, i.e., how a facilitator operationalizes the role. Scholars continue to call for a better understanding of this implementation strategy. Although facilitation is described as dynamic, activities are often framed within the context of a staged process. We explored two understudied characteristics of implementation facilitation: 1) how facilitation activities change over time and in response to context, and 2) how facilitators operationalize their role when the purpose of facilitation is both task-focused (i.e., to support implementation) and holistic (i.e., to build capacity for future implementation efforts.
Methods: We conducted individual monthly debriefings over thirty months with one external expert and two internal regional facilitators who were supporting PCMHI implementation in two VA networks. We developed a list of facilitation activities based on a literature review and debriefing notes. We coded what activities occurred and their intensity by quarter. We also coded whether facilitators were “doing” these activities for sites or “enabling” sites to perform them.
Results: Implementation facilitation activities did not occur according to a defined series of ordered steps but in response to specific organizational contexts through a non-linear and incremental process. Amount and types of activities varied between the networks. Concordant with facilitators’ planned role, the focus of some facilitation activities was primarily on doing them for the sites and others on enabling sites to do for themselves; a number of activities did not fit into one category and varied across networks.
Conclusions: Findings indicate that facilitation is a dynamic and fluid process, with facilitation activities, as well as their timing and intensity, occurring in response to specific organizational contexts. Understanding this process can help those planning and applying implementation facilitation to make conscious choices about the facilitation role on the doing/enabling continuum, and the activities that facilitators can use to operationalize this role. Additionally, this work provides the foundation from which future studies can identify potential mechanisms of action through which facilitation activities enhance implementation uptake.