bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐step implicit Adams predictor‐corrector network for fire detection
Authors: Deng Zhen , Hu Shuhao , Yin Shibai , Wang Yibin , Basu Anup , Cheng Irene 
Published: April 2022

AbstractFire detection methods based on the Convolutional Neural Networks (CNN) have advantages of high accuracy, wide coverage and robustness, receiving significant attention from researchers. Among CNN‐based methods, ResNet has achieved better performance than other CNN frameworks in fire detection system, since it uses stacked residual blocks to enlarge the receptive field to overcome the vanishing gradient problem with residual learning. The merits of ResNet can be attributed to the similarity between ResNet and the single‐step explicit solver for Ordinary Differential Equations (ODEs), for example, the Euler method. Motivated by the theory of numerical ODE that a multi‐step implicit solver has higher accuracy than a single‐step explicit solver, the Multi‐step Implicit Adams predictor‐corrector (MIAPC) network for fire detection is proposed. The MIAPC method is first mapped to a corresponding predictor‐corrector Adams block which achieves higher accuracy than a single‐step explicit solver. Then, Adaptive Feature Fusion (AFF) and the Spatial Attention Layer (SAL) are utilized to extract hierarchical features from stacked predictor‐corrector Adams blocks, forming the corresponding Adams module. Finally, the 4 Adams modules which are made of 4, 6, 8, 10 predictor‐corrector Adams blocks and followed by AFF and SAL form the crucial ODE‐based approximation part in the proposed network. By adding a simple feature extraction and detection in front of and after the ODE‐based approximation part, the MIAPC network is built. Experiments demonstrate that the method achieves 87% accuracy in the challenging test dataset, outperforming existing methods by at least 6%. Besides, the 5.3M model size with inference speed of 4.7 frames/second in CPU and 65.7 frames/second in GPU enables the proposed method to be used in practical applications.
Coherent processing for randomized stepped‐frequency radar in multi‐target scenario
Authors: Liu Shuai , Cao Yunhe , Yeo Tat‐Soon , Wang Fengfei , Zhao Yuchao 
Published: April 2022

AbstractRandomized stepped‐frequency (RSF) radar has the potential of realizing joint high‐resolution range‐Doppler estimation. However, estimating multiple targets' two‐dimensional parameters at high efficiency based on RSF waveforms is still a difficult issue. In this study, a novel algorithm, which estimates multiple targets' velocities by using different frequencies pulses and then generates their high‐range‐resolution profiles (HRRPs), is proposed for RSF radar. In the velocities estimation, by setting a certain difference‐frequency parameter, a set of signals with constant range‐phase terms and changing velocity‐phase terms is constructed and then used to generate a new generalized Doppler spectrum called the difference‐frequency Doppler spectrum (DFDS). To suppress rising noise floors caused by sidelobes and cross‐terms in the DFDS, DFDSs corresponding to different difference‐frequency parameters are non‐coherently integrated to obtain a so‐called accumulated DFDS. From the accumulated DFDS, targets are detected and their velocities are estimated. In the HRRPs generation, a special dictionary matrix is structured by using the estimated velocities, and each target HRRP, without interference from other targets, is generated via the compressed sensing (CS) technique. The proposed algorithm avoids huge computation burden by separately performing Doppler and range process, and guarantees the performance in a multi‐target scenario via the noise floors suppression and CS.
The He–H3+ complex. II. Infrared predissociation spectrum and energy term diagram
Authors: Salomon Thomas , Brackertz Stefan , Asvany Oskar , Savić Igor , Gerlich Dieter , Harding Michael E. , Lipparini Filippo , Gauss Jürgen , van der Avoird Ad , Schlemmer Stephan 
Published: April 2022

The rotationally resolved infrared (IR) spectrum of the He–H3+ complex has been measured in a cryogenic ion trap experiment at a nominal temperature of 4 K. Predissociation of the stored complex has been invoked by excitation of the degenerate ν2 mode of the H3+ sub-unit using a pulsed optical parametric oscillator system. An assignment of the experimental spectrum became possible through one-to-one correlations with bands of the spectrum theoretically predicted in Paper I [Harding et al., J. Chem. Phys. 156, 144307 (2022)]. 19 bands have been assigned and analyzed, and the energy term diagram of the lower states of this floppy molecular complex has been derived from combination differences (CDs) in the experimental spectrum. Ground state combination differences (GSCDs) reveal a large part of the energy term diagram for the He–H3+ complex in its vibrational ground state, v = 0. Experimental and theoretical term energies agree within experimental accuracy for the rotational fine structure associated with the total angular momentum quantum number J and the parity e/f as well as for the coarse spacing of the lowest K states of the complex. This favorable comparison shows that the potential energy surface (PES) calculated in Paper I is accurate. The barriers between the three equivalent global minima in this PES are relatively low and the He–H3+ complex is extremely floppy, with nearly unhindered internal rotation of the H3+ sub-unit. The resulting Coriolis interactions couple the internal and end-over-end rotation of the complex and contribute significantly to the energy terms. They are observed both in experiment and theory and are, e.g., the origin of different rotational constants for states of e and f parity. Also in this respect, experiment and theory agree very well. Despite the assignment and analysis of many bands of the extremely rich IR spectrum of He–H3+, higher levels of excitation, including the complex stretching mode, need further attention.
Identifying engaging bird species and traits with community science observations
Authors: Stoudt Sara , Goldstein Benjamin R. , de Valpine Perry 
Published: April 2022

SignificanceConservation outreach has long depended on an intuitive sense of which species are more “charismatic” or engaging, for example, placing focus on certain charismatic megafauna in advertising materials. Online community science databases like eBird and iNaturalist provide records of how people engage with different birds under differing data collection protocols. Comparisons between the two databases reveal biases in bird reporting rates. Larger, more colorful, and rarer birds are preferentially engaged with opportunistically in iNaturalist records compared to more systematic eBird records. These relationships and the species-specific engagement indexes determined from these data can be applied to conservation and outreach efforts to help foster a public relationship with nature and can be used to improve models using these two databases.
MicroRNA networks in FLT3-ITD acute myeloid leukemia
Authors: Hoang Dinh Hoa , Zhao Dandan , Branciamore Sergio , Maestrini Davide , Rodriguez Ivan R. , Kuo Ya-Huei , Rockne Russell , Khaled Samer K. , Zhang Bin , Nguyen Le Xuan Truong , Marcucci Guido 
Published: April 2022

Significance
We report on a deregulatory activity on microRNA (miRNA) biogenesis by the FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) in acute myeloid leukemia. FLT3-ITD provides a divergent signal for concurrent and aberrant miR-155 up-regulation and miR-126 down-regulation via a series of miRNA–protein regulatory loops interconnected through SH2-containing inositol phosphatase 1 (SHIP1)/phosphor-protein kinase B (AKT)/Sprouty related EVH1 domain containing 1 (SPRED1) signaling. This divergent input signal eventually converges and amplifies an output signal for leukemic growth.
The Long chain Diol Index: A marine palaeotemperature proxy based on eustigmatophyte lipids that records the warmest seasons
Authors: Rampen Sebastiaan W. , Friedl Thomas , Rybalka Nataliya , Thiel Volker 
Published: April 2022

Significance
Organisms adjust their lipid compositions to environmental conditions like temperature. Some adaptations involve changes in ratios between unique lipids, which can still be determined after millions of years. Analyzing such lipid ratios in ancient sediments can be used for climate reconstruction. One example is the Long chain Diol Index (LDI). The lipids, produced by unknown biological sources, occur ubiquitously in marine sediments, and the LDI correlates with temperature. However, LDI records often differ from other temperature reconstructions. We now show that a clade of eustigmatophyte algae produces these lipids, providing information on their evolutionary history. We further demonstrate that the LDI registers temperatures of the warmest months instead of annual mean temperatures, which is valuable information for climate research.
Tryptophan regulatesDrosophilazinc stores
Authors: Garay Erika , Schuth Nils , Barbanente Alessandra , Tejeda-Guzmán Carlos , Vitone Daniele , Osorio Beatriz , Clark Adam H. , Nachtegaal Maarten , Haumann Michael , Dau Holger , Vela Alberto , Arnesano Fabio , Quintanar Liliana , Missirlis Fanis 
Published: April 2022

SignificanceZinc deficiency in the human population, a major public health concern, can also be a consequence of nutritional deficiency in protein uptake. The discovery that tryptophan metabolites 3-hydroxykynurenine and xanthurenic acid are major zinc-binding ligands in insect cells establishes the kynurenine pathway as a regulator of systemic zinc homeostasis. Many biological processes influenced by zinc and the kynurenine pathway, including the regulation of innate and acquired immune responses to viral infections, have not been studied in light of the direct molecular links revealed in this study.
MoSBi: Automated signature mining for molecular stratification and subtyping
Authors: Rose Tim Daniel , Bechtler Thibault , Ciora Octavia-Andreea , Anh Lilian Le Kim , Molnar Florian , Köhler Nikolai , Baumbach Jan , Röttger Richard , Pauling Josch Konstantin 
Published: April 2022

SignificanceMolecular patient stratification and disease subtyping are ongoing and high-impact problems that rely on the identification of characteristic molecular signatures. Current computational methods show high sensitivity to custom parameterization, which leads to inconsistent performance on different molecular data. Our new method, MoSBi (molecular signature identification using biclustering), 1) enables so far unmatched high performance for stratification and subtyping across datasets of various different biomolecules, 2) provides a scalable solution for visualizing the results and their correspondence to clinical factors, and 3) has immediate practical relevance through its automatic workflow where individual selection, parameterization, screening, and visualization of biclustering algorithms is not required. MoSBi is a major step forward with a high impact for clinical and wet-lab researchers.
Correlation of plastic events with local structure in jammed packings across spatial dimensions
Authors: Ridout Sean A. , Rocks Jason W. , Liu Andrea J. 
Published: April 2022

SignificanceMean-field theories, exact in the limit of infinite spatial dimensions, succeed in describing many features of glasses and amorphous solids in low dimensions, leading to considerable effort to understand how behavior evolves with dimension. Until now, all evidence has supported a picture in which “localized physics,” responsible for deviations from mean-field behavior in low dimensions, fades away with rising dimension. Our work shows that rearrangements, in which particles change relative positions leading to fluid-like response, reveal a different picture of dimensional cross-over. We find that rearrangements, which are localized in two- and three-dimensional systems and correlated with local structure, remain just as correlated with local structure up to five dimensions, suggesting that local structure is important even in high dimensions.
Genetic architecture facilitates then constrains adaptation in a host–parasite coevolutionary arms race
Authors: Spottiswoode Claire N. , Tong Wenfei , Jamie Gabriel A. , Stryjewski Katherine F. , DaCosta Jeffrey M. , Kuras Evan R. , Green Ailsa , Hamama Silky , Taylor Ian G. , Moya Collins , Sorenson Michael D. 
Published: April 2022

Significance
Validating an almost century-old hypothesis, we show that a critical host-specific adaptation in a brood-parasitic bird, mimicry of host egg coloration, is maternally inherited, allowing mothers to transmit specialized mimicry to their daughters irrespective of the father’s host species. This genetic architecture, however, is a double-edged sword for parasites: the loss of recombination and heterozygosity as sources of evolutionary novelty likely constrains the parasite from mimicking the full range of color polymorphisms that hosts have evolved as an escalated defense against parasitism. This important tradeoff of asexual inheritance may have relevance for understanding coevolution in other host–parasite systems.
A high-affinity cocaine binding site associated with the brain acid soluble protein 1
Authors: Harraz Maged M. , Malla Adarsha P. , Semenza Evan R. , Shishikura Maria , Singh Manisha , Hwang Yun , Kang In Guk , Song Young Jun , Snowman Adele M. , Cortés Pedro , Karuppagounder Senthilkumar S. , Dawson Ted M. , Dawson Valina L. , Snyder Solomon H. 
Published: April 2022

Significance
Cocaine is a monoamine transport inhibitor. Current models attributing pharmacologic actions of cocaine to inhibiting the activity of the amine transporters alone failed to translate to the clinic. Cocaine inhibition of the dopamine, serotonin, and norepinephrine transporters is relatively weak, suggesting that blockade of the amine transporters alone cannot account for the actions of cocaine, especially at low doses. There is evidence for significantly more potent actions of cocaine, suggesting the existence of a high-affinity receptor(s) for the drug. Identifying and characterizing such receptors will deepen our understanding of cocaine pharmacologic actions and pave the way for therapeutic development. Here we identify a high-affinity cocaine binding site associated with BASP1 that is involved in mediating the drug’s psychotropic actions.
The interface between instructed L2 pragmatics and TBLT research
Authors: Kim YouJin 
Published: April 2022

AbstractOver the past two decades, the theoretical backgrounds of instructed second language (L2) pragmatics studies have diversified, and instructional materials have been designed and implemented based on various theories of second language acquisition (SLA). As a result, the field of instructed pragmatics has made significant strides in developing empirically driven, effective instructional methods. Recently, researchers in the fields of task-based language teaching (TBLT) and L2 pragmatics have claimed there are synergistic effects when teaching pragmatics from a TBLT perspective. These researchers argue that both pragmatics instruction and TBLT approaches to language teaching highlight the importance of language use in authentic contexts and achieving communication goals. The focus of the current review article is on task design and implementation in L2 pragmatics research, particularly those studies which were conducted from a TBLT perspective. Pedagogical implications of these studies are discussed, and future directions for task-based approaches to teaching L2 pragmatics for both research and pedagogy are proposed.
The association between recall of historical events and well-being (La asociación del recuerdo de eventos históricos con el bienestar)
Authors: Méndez Lander , Cavalli Stefano , Pizarro José J. , Telletxea Saioa , Castro-Abril Pablo , Padoan Sonia , Páez Darío 
Published: April 2022

This study explores the relationship between remembered sociohistorical events and well-being. Its objective is to ascertain the content of historical memory and the way it is associated with this construct. The PHI remembered well-being scale and the CEVI instrument, which asks respondents to describe four relevant historical events during their lifetime, were applied to a convenience sample from the Basque Country ( N = 434, range 20–88 years, M = 48.11, SD = 21.47, 59.2% women). Negative and local events predominated. Positive appraisal of historical events was positively associated with personal, hedonic and social well-being, and negative appraisal was positively associated with lower well-being, confirming the greater importance of positive recall in well-being. A stronger relationship between the recall of historical events, particularly positive ones, and the hedonic and social facets of well-being was observed than with personal well-being.
A longitudinal analysis of social class and adolescent prosocial behaviour: a latent growth model approach (Un análisis longitudinal de clase social y conducta prosocial adolescente: un enfoque de modelo de crecimiento latente)
Authors: Yao Zhuojun , Enright Robert 
Published: April 2022

The current research used longitudinal data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development ( N = 1,091) to examine the link between social class and prosocial behaviour from third grade to sixth grade. Latent growth modelling found that adolescents from families with increased income-to-needs ratio tended to experience an increase in prosocial behaviour from third grade to sixth grade; adolescents from families with high income-to-needs ratio in third grade were more likely to be identified as the class of high initial with decrease; adolescents in the profile of high initial with decrease tended to be more prosocial in each grade and came from families with higher levels of income-to-needs ratio, higher parental education and higher parental occupation. Implications and future directions were presented.
3D printing of sponge spicules-inspired flexible bioceramic-based scaffolds
Authors: Yang Zhibo , Xue Jianmin , Li Tian , Zhai Dong , Yu Xiaopeng , Huan Zhiguang , Wu Chengtie 
Published: April 2022

Abstract
Bioceramics are widely used in bone tissue repair and regeneration due to their desirable biocompatibility and bioactivity. However, the brittleness of bioceramics results in difficulty of surgical operation, which greatly limits their clinical applications. The spicules of the marine sponge Euplectella aspergillum (Ea) possess high flexibility and fracture toughness resulting from concentric layered silica glued by a thin organic layer. Inspired by the unique properties of sponge spicules, flexible bioceramic-based scaffolds with spicule-like concentric layered biomimetic microstructures were constructed by combining two-dimensional (2D) bioceramics and 3D printing. 2D bioceramics could be assembled and aligned by modulating the shear force field in the direct ink writing (DIW) of 3D printing. The prepared spicules-inspired flexible bioceramic-based (SFB) scaffolds differentiated themselves from traditional 3D-printed irregular particles-based bioceramic-based scaffolds as they could be adaptably compressed, cut, folded, rolled and twisted without the occurrence of fracture, significantly breaking through the bottleneck of inherent brittleness of traditional bioceramic scaffolds. In addition, SFB scaffolds showed significantly enhanced in vitro and in vivo bone-forming bioactivity as compared to conventional β-tricalcium phosphate (β-TCP) scaffolds, suggesting that SFB scaffolds combined both of excellent mechanical and bioactive characteristics, which is believed to greatly promote the bioceramic science and their clinical applications.
Microstructure evolution and electrochemical corrosion behavior of Al–Zn–Mg aluminum alloy
Authors: Dun-Bo Teng , Hong Zhang , Cui-Hong Han , Yu-Rong Xu , Zhen Liu , Ri-Qiang Zhang , Xiao Chen 
Published: April 2022

Abstract
Electrochemical corrosion behavior of Sn-containing Al–Zn–Mg aluminum alloy has been studied in detail. The localized corrosion behaviors were studied by electrochemical impedance spectroscopy (EIS) analysis, and the potentiodynamic polarization measurements. The grain structure, grain-boundary microstructure, grain-boundary microchemistry, pitting and intergranular corrosion morphology were characterized and observed using SEM, EDS, TEM, SAED and HRTEM analyses. Based on these tests, the effects of grain-boundary on the corrosion resistance in our Sn-containing Al–Zn–Mg alloys before/after bake hardening were analyzed systematically. Finally, the relationship between chemical composition, microstructure evolution and corrosion behaviour was revealed. The results indicate that the bake hardening process improves the corrosion resistance compared to the pre-aging state. The grain size has little effect on the electrochemical corrosion bahavior.
Evaluation of a method to measure fluorescent cell burden in complex culture systems
Authors: Holden R , Park J , Price A , Floyd S , Oldham M 
Published: April 2022

Abstract

Purpose. This work introduces and evaluates a method for accurate in-vitro measurement of fluorescent cell burden in complex 3D-culture conditions. Methods. The Fluorescent Cell Burden (FCB) method was developed to analyze the burden of 4T1 mCherry-expressing cells grown in an organotypic co-culture model of brain metastasis using 400 μm rat brain slices. As a first step, representative simulated image-data accurately reflecting the 4T1 experimental data, but with known ground truth burden, were created. The FCB method was then developed in the CellProfiler software to measure the integrated intensity and area of the colonies in the simulated image data. Parameters in the pipeline were varied to span the experimentally observed range (e.g. of cell colony size) and the result compared with simulation ground truth to evaluate and optimize FCB performance. The optimized CellProfiler pipeline was then applied to the original 4T1 tumor cell images to determine colony growth with time, and re-applied with upper and lower bound parameters to determine uncertainty estimates. Results. The FCB method measured integrated intensity across 10 simulated images with an accuracy of 99.23% ± 0.75%. When colony density was increased by increasing colony number to 450, 600, and 750, the FCB measurement was 98.68%, 100.9%, 97.6% and 113.5% of the true value respectively. For the increasing number of cells plated on the rat brain slices, the integrated intensity increased nearly linearly with cell count except for at high cell counts, where it is hypothesized that shadowing from clumped cells causes a sub-linear relationship. Conclusion. The FCB method accurately measured an integrated fluorescent light intensity to within 5% of ground truth for a wide range of simulated image data spanning the range of observed variability in experimental data. The method is readily customizable to in-vitro studies requiring estimation of fluorescent tumor cell burden.