bluuebunny/crossref_metadata_2025_split huggingface dataset:
604 From admission to discharge: a total friction burn review from a single institution
Authors: Estrada Munoz Oscar I , Sabour Andrew F , Carroll Joseph T , Flores Carmen E , Fraser Douglas R , Chestovich Paul J , Saquib Syed F 
Published: March 2022

Abstract

Introduction
Most friction burns are adequately managed in an outpatient setting. However, many require hospital admission, operative excision, and extended care especially those that present at trauma or burn centers. There is a wide variance in friction burn management. Our goal is to review the etiology, management, and outcomes of such burns warranting hospitalization.

Methods
We conducted a retrospective review of all friction burns admitted to a single, American Burn Association verified burn center from January 1, 2016 to December 31, 2020. Individual chart analysis was performed using data from the hospital’s burn registry. Statistical analysis was performed using Chi-square and Wilcoxon rank-sum test with p&lt; 0.05 being significant.

Results
Eighty-two patients met the inclusion criteria. Mean age was 35.4 years (95% CI 31.6-39.2). The overall mean Total Body Surface Area (TBSA) was 9.0 % (95% CI 7.5-10.6), and mean TBSA of 3rd degree burns was 1.1 % (95% CI 0.6-1.7). The most common mechanism of injury was motorcycle collision (45, 55%), followed by pedestrian struck by automobile (13, 16%). Fifty-four individuals (65%) had a concomitant injury. The most common topical agent used was silver sulfadiazine (52%), followed by bacitracin (21%). Sixteen patients (20%) required ICU level of care. Twenty-eight (34%) patients required surgery for their friction burns and 15 (18%) ultimately required a split-thickness skin graft. The mean number of operations was 2.4 (95% CI 1.6-3.1).
Overall, the operative group was younger (29.9 vs 38.3 years, p=0.026), more likely to have a concomitant traumatic brain injury (25% vs 7%, p=0.027) and had a longer hospital length of stay (17.5 vs 3.9 days, p&lt; 0.001). Both groups had a similar overall TBSA (8.5% vs 10.0%, p=0.35), but the operative group had larger surface area comprised of 3rd degree burns (3.05% vs 0.2%, p&lt; 0.001). Eighty-one patients survived with the sole death due to massive hemoptysis.

Conclusions
Friction burns resulting in hospital admission are associated with high-energy traumatic mechanisms and concomitant injuries. Patients who need operative intervention of their burns typically require multiple procedures often culminating in a split-thickness skin graft.
606 Novel application of a surgeon-operated clysis delivery system in burn surgery
Authors: Morzycki Alexander , Wong Joshua N 
Published: March 2022

Abstract

Introduction
Tangential excision of burns is associated with significant bleeding. Sub-eschar insufflation of epinephrine-containing clysis has shown to decrease blood loss and associated complications. Administration of adrenaline-containing infiltrates are also beneficial in the harvest of split thickness skin grafts. Clysis is typically delivered with the assistance of a perfusionist-operated system. This method, however, is associated with significant cost and dependent on personnel availability. This study evaluated the use of a novel surgeon-operated fluid management system in the delivery of clysis in burn surgery.

Methods
Our initial experience with a novel fluid management system is presented. Prospective collection of infiltration data, including average temperature, pressure, and volume of clysis was performed. Patient and burn factors were evaluated and complications collected. Finally, a cost-effectiveness analysis was conducted.

Results
Thirty-seven consecutive cases comprising 22 adult patients (15/22, 68% male), with a mean age of 49 years (+/- 19) were reviewed. The mean % total body surface area of all patients was 39 (+/- 21.7). The mean temperature, pressure and volume of administered clysis was 32.2 degrees Celsius (+/- 4.4), 265.04 mmHg (+/-56.17), and 5805.8 mL (+/- 4844.4), respectively. The mean dose of epinephrine administered was 14.5mg (+/- 12.1). The mean temperature variability was 1.1 °C (+/- 1.2). Total mean packed red blood cells (PRBC) transfused was 507.6 mL (+/- 624.4). There were no recorded complications. We identified a cost savings of $20,766 CAD over the cases examined.

Conclusions
We present the novel application of a fluid management system in burn surgery. This technique provides rapid and safe infiltration of warmed clysis. We are able to maintain intra-operative euthermia despite a large volume of administered clysis and significant intraoperative vulnerability to hypothermia. In addition, this technique may be transfusion-sparing. The introduction of this method of clysis administration was associated with significant cost-savings.
608 Utilization of Phase-Based Guidelines For Patient Care After Application of Cultured Epithelial Autograft
Authors: Ewanowski Kathleen M , Bramble Caitlin , Anyan Walter R , Fleming Irma D , Hopkins Ronda , Morris Stephen E , Thompson Callie M , Lewis Giavonni M 
Published: March 2022

Abstract

Introduction
Cultured epithelial autografts (CEA) have been clinically utilized since 1981 & can be a lifesaving procedure in patients with extensive full thickness burns. CEA is more susceptible to bacterial contamination & complete graft loss than traditional split-thickness autografts, yet no standard of practice exists for the postoperative care of these grafts to minimize infection & maximize graft take.
Prior to 2019, care of CEA patients at our institution was not standardized & instead varied upon the attending surgeon’s practice. With the input of interdisciplinary team members, CEA patient care was standardized via phase-based guidelines (PBGs), leading to improved team communication & improved patient outcomes.

Methods
PBGs were created via interdisciplinary collaboration among surgeons, APCs, nursing staff, PT/OT, & psychosocial providers. Team members agreed upon 3 facets of patient care: Wound Care/Airing Out, Restrictions/Visitors, & Burn Therapy (Figure 1). As wounds progressed postoperatively, patient phases were advanced, liberalizing them from rigorous infection-prevention techniques to strict unit standards for non-CEA burn patients.
In 2019, the utilization of patient-specific CEA care plans ceased in favor of standardized PBGs. A retrospective chart review was conducted on all patients from 2018-2021 who received CEA & survived their injuries. Some patients underwent a single CEA application while others underwent multiple operations. CEA graft take was assessed on all wounds from each surgery.

Results
CEA was rarely used at our institution. Beginning in 2018, seven patients received CEA & survived their injuries, ranging in age from 4-59 yrs (mean 24) & %TBSA from 38-80 (mean 53) (Table 1). Implementation of PBGs correlated with subjective improvement in team communication & increased mean percentages of CEA graft take from &lt; 35% to &gt;75%.

Conclusions
PBGs have standardized care for our CEA patients, eliminated communication errors among team members, & increased CEA graft take. Further research is needed to determine efficacy in decreasing infection, antibiotic use, hospital stay length, & mortality in these patients.
614 Laser-treatment of Hypertrophic Scar Induces Change to Epidermal Histoarchitecture Correlating to Improved Epidermal Barrier Function
Authors: Jimenez Lesle M , Oliver Mary A , Keyloun John W , Travis Taryn E , Shupp Jeffrey W , Moffatt Lauren T , Carney Bonnie C 
Published: March 2022

Abstract

Introduction
Mechanisms and timing of hypertrophic scar (HTS) improvement with laser therapy are incompletely understood. Epidermal keratinocytes influence HTS through paracrine signaling, yet they are understudied compared to fibroblasts. It was hypothesized that fractional ablative CO2 laser scar revision (FLSR) would change the fibrotic histoarchitecture of the epidermis in HTS.

Methods
Duroc pigs (n=4 FLSR and n=4 controls) were injured and allowed to form HTS. HTS and normal skin (NS) were assessed weekly by non-invasive skin probes measuring trans-epidermal water loss (TEWL) and biopsy collection. There were 4 weekly FLSR treatments. Early laser treatment began on day 49, and late began on day 77. Punch biopsies from NS and HTS were processed and stained with H&E. Image J was used to obtain epidermal thickness and rete ridge ratios (RRR). Gene and protein expression of involucrin (IVL) was examined through qRT-PCR and immunofluorescent (IF) staining.

Results
After treatment, peeling sheets of stratum corneum were apparent which were not present in the controls. TEWL was increased in HTS vs. NS at day 49 indicating decreased barrier function (42.2±8.0 vs. 22.0±4.62g/m2h, p=0.05). In the early group, TEWL was significantly decreased at week 4 to 16.4±3.5 g/m2h (p&lt; 0.05). The late group was not significantly altered from NS at the pre-laser timepoint (day 77=12.1±1.99 g/m2h). Hence, there was no decrease in TEWL post-FLSR. After 4 sessions, epidermal thickness was significantly increased in treated scars in both FLSR groups (early:pre=85.6±6.8 vs. week 4=115.2±12.0 µm, p&lt; 0.01) and (late:pre=75.2±6.6 vs. week 4=125.7±12.0 µm p&lt; 0.001, n=8 scars,). There was no increase in controls. Late intervention significantly increased RRR (pre=1.3±0.1 vs. week 4=1.9±0.1, n=8 scars, p&lt; 0.05), and early treatment trended towards increase (pre=1.17±0.05 vs. week 4=1.4 + 0.1). There was no increase in controls. There was increased IVL gene expression in HTS vs. NS that decreased after FLSR. Eight scars had up-regulated gene expression of IVL vs. NS levels pre-treatment (FC &gt;1.5) compared to 4 scars at week 4. This was confirmed by IF where IVL staining decreased at week 4.

Conclusions
Changes in epidermal HTS histoarchitecture and expression levels of epidermal differentiation markers were induced by FLSR. The timing of laser intervention contributed to differences in TEWL, epidermal thickness, and RRR.
615 Evaluation of Topical Off-The-Shelf Therapies to Improve Burn Wound Healing During Prolonged Field Care
Authors: Varon David E , Nuutila Kristo , Cooper Laura E , Chapa Javier , Valdera Franklin , Christy Sean E , Christy Robert J , Chan Rodney K , Carlsson Anders H 
Published: March 2022

Abstract

Introduction
Burns are common injuries in the battlefield. Given austere environments, prolonged field care (PFC) is often necessary. Delays in surgical debridement create a risk of infection and deranged healing for burn patients. As such, this study attempts to identify the best commercially available off-the-shelf (OTS) dressings with field-deployable potential.

Methods
Deep-partial thickness burns (1" diameter) were created on the dorsum of 3 anesthetized pigs utilizing a thermocoupled burn device at 100°C for 15s. Non-surgical debridement was done 1-h post-burn creation and either an OTS dressing or standard-of-care (SOC) treatment (Silver Sulfadiazine) was applied to the wound in order to simulate a PFC environment. OTS dressings were randomized and included irradiated sterile human skin allograft (ISHSA), alloplastic absorbable skin substitute (AASS), and synthetic polyurethane dermal matrix (SPDM). Wounds were serially assessed on post-burn days 3, 7, 14, 21, and 28. Assessments were conducted using a combination of photographs, histology, and quantitative bacteriology. Endpoints included burn wound progression, re-epithelialization, wound contraction, scar elevation index (SEI), and colony forming units (CFU).

Results
No statistically significant differences in burn wound progression were seen on days 3 and 7 for the ISHSA or SPDM and the SOC. The differences between the AASS and the SOC were statistically significant on both days (p≤0.05). Day 21 re-epithelialization results for the ISHSA, AASS, SPDM and SOC treated wounds were 30%, 85%, 95%, and 78% re-epithelialized, respectively. The difference between the AASS and the SOC was statistically significant (p≤0.05). Results showed that by day 28, wound contraction for the ISHSA, AASS, SPDM and SOC treated wounds were 65%, 80%, 82%, and 78%, respectively. No statistically significant differences in wound contraction were seen for any of the OTS dressings and the SOC. SEI showed no statistically significant difference in scar hypertrophy between the OTS dressings and the SOC on day 28. CFU results showed no statistically significant differences between the OTS dressings and the SOC on days 3 and 7.

Conclusions
Three OTS dressings were compared to the SOC for use in the PFC setting. Generally, all the dressings performed well when compared to the SOC in terms of burn wound progression, re-epithelialization, wound contraction, SEI, and CFU. Although significant differences in burn progression and re-epithelialization for burns treated with AASS were seen. In the future, we hope to continue to discover and test various OTS dressings to determine their appropriateness for use in the PFC setting.
617 Indocyanine Green: Harnessing Novel Methods to Identify Burn Wound Healing Potential
Authors: Zajac Jocelyn C , Gibson Angela , Liu Aiping , Hassan Sameeha E 
Published: March 2022

Abstract

Introduction
Objective determination of burn wound healing potential remains elusive and significantly impacts decision making for surgery, the extent of tissue excised intraoperatively and the use of donor site-sparing alternative tissue therapies. Indocyanine green angiography (ICGA) has promise as an adjunct to evaluate healing potential, but feasibility has limited adoption in clinical practice. Delayed fluorescence imaging of indocyanine green (ICG), in a method called second-window ICG (SWIG), is a new technique used intraoperatively to guide tumor resection via increased peritumoral endothelial permeability. The objective of this study is to examine ICGA and SWIG fluorescence in burns requiring excision and grafting, and to correlate SWIG fluorescence to microscopic localization of inflamed and necrotic tissue.

Methods
Deep partial thickness, indeterminate depth or full thickness burns were identified in adult patients scheduled for excision and grafting. 24 hours prior to surgery, baseline bright light and fluorescence images were obtained before the administration of up to 5 mg/kg ICG intravenously. ICGA was performed within 5 minutes of infusion initiation. On the day of surgery, bright light and SWIG fluorescence images were obtained before and after burn excision. The excised tissue was imaged ex-vivo to determine the presence of fluorescence in the tissue compared to that remaining within the wound bed. Excised tissue was processed for histologic analysis of cellular architecture, viability, inflammation and necrosis. Macroscopic ICGA and SWIG fluorescence images were compared to the associated microscopic tissue sections to determine the presence of inflammatory infiltrate, localization of non-viable tissue, and co-localization of ICG fluorescence.

Results
ICGA imaging performed preoperatively demonstrated variable fluorescence throughout the burns without a clear cutoff value to delineate deep partial versus full thickness burns. SWIG imaging revealed a speckled fluorescence pattern prior to burn excision that became diffuse after excision suggesting a potential utility of SWIG to intraoperatively identify excision completion. ICGA and SWIG fluorescence demonstrated an inverse relationship, and SWIG fluorescence was associated with non-viable tissue.

Conclusions
ICGA imaging alone was unreliable to delineate the need for surgical intervention. SWIG imaging of burn injuries may represent a valuable tool to guide the extent of excision intraoperatively and reduce unnecessary excision of viable tissue. Further studies are needed to understand SWIG fluorescence at the inflammation-necrosis border and how ICGA fluorescence along with SWIG can synergistically improve detection of healing potential in burn patients.
702 Outcomes of COPD Patients with Burn Injuries at a Single Institution
Authors: Sljivic Sanja , Chrisco Lori , Nizamani Rabia , King Booker , Matthews R O B E R T W , Williams Felicia 
Published: March 2022

Abstract

Introduction
Chronic obstructive pulmonary disease (COPD) is a condition with significant morbidity and mortality. In 2018, about 16 million adults in the United States reported a diagnosis of COPD based on data from the American Lung Association. Home oxygen is often used in more severe cases of COPD, and despite warnings against smoking while using home oxygen, many patients continue to sustain burn injuries. An existing diagnosis of COPD can further complicate management of a burn patient, especially if there is concomitant inhalation injury present. The objective of this study was to explore the outcomes of COPD patients admitted to our Burn Center.

Methods
This was a single-site, retrospective review using our institutional Burn Center registry. All adult patients with flame burns (18 years or older) admitted to our Burn Center between July 1, 2011 and June 30, 2020 who had a history of COPD with and without home oxygen use were included in this study. All adult patients with flame burns, who did not have a history of COPD, were included for comparative purposes. Variables of interest included demographics, burn mechanism, length of stay (LOS), ICU and ventilator days, and mortality.

Results
There were a total of 4,397 patients with flame burns included in this study, and 515 of those patients were identified to have an existing diagnosis of COPD. The mean age of the COPD group was 45.1 years +/- 13.0 years, and the patient population was predominantly male (60.4%). The mean total body surface area (TBSA) involvement was 5.12% +/- 10.38%. Inhalation injury was present in 10.1% of patients with COPD and in 7.8% of those without COPD. The mean LOS for the COPD group was 11.9 days +/- 19.4 days and 13.4 days +/- 31.0 days for the non-COPD group. The mean ICU LOS for the COPD group was 11.2 days +/- 19.9 days and 18.0 days +/- 37.0 days for the non-COPD group. The mean number of ventilator days was 16.5 days +/- 35.4 days for the COPD group and 26.3 days +/- 42.0 days for the non-COPD group. The overall hospital mortality was 10.3% for the COPD group and 4.3% for the non-COPD group.

Conclusions
This study demonstrates that the overall hospital mortality was highest in the COPD group. Although hospital and ICU length of stay, as well as the number of ventilator days were higher in the non-COPD group, it remains clear that an existing diagnosis of COPD can negatively impact the outcomes of burn patients.
710 Specific Patterns of Vital Sign Fluctuations Predict Bloodstream Infection in Pediatric Burn Patients
Authors: Sadeq Farzin , Poster Jonah , Weber Joan M , Begis Maggie D , Sheridan Robert L , Uygun Korkut 
Published: March 2022

Abstract

Introduction
Early recognition of the clinical signs of bloodstream infection in pediatric burn patients is key to improving survival rates in the burn unit. The objective of this study was to propose a simple scoring criteria that used readily available temperature, heart rate (HR) and mean arterial pressure (MAP) data to accurately predict bloodstream infection in pediatric burn patients.

Methods
A retrospective chart review included 100 patients admitted to the pediatric burn unit for &gt;20% total body surface area (TBSA) burn injuries. Each patient had multiple blood culture tests, and each test was treated as a separate and independent “infection event” for analysis. The time at each blood culture draw was time 0 for that event, and temperature, HR and MAP data was collected for 24 hours after the blood culture was drawn. “Infection events” included in this study had at least six complete sets of temperature, HR and MAP data entries. Median temperature, HR and MAP, as well as mean fever spikes, HR spikes and MAP dips, were compared between infection group (positive blood cultures) and control group (negative blood cultures). These vital sign fluctuations were evaluated individually and as a combination of all three as timely predictors of bloodstream infection. In addition, we tested the prediction of Gram-negative bacteria versus Gram-positive or fungi present in blood cultures.

Results
Patients in the infection group had significantly higher median temperatures (p&lt; 0.001), mean fever spikes (p&lt; 0.001) and mean HR spikes (p&lt; 0.001), compared to the control group. Using the combination scoring criteria to predict bloodstream infection, the strongest predictive values in the 24-hour timeframe had high sensitivity (93%) and specificity (81%). The predictive test metric based on vital sign spikes predicted Gram-negative bacteria, but with limited sensitivity (57%) and specificity (44%).

Conclusions
This study found that using a combination scoring criteria of fever spikes, HR spikes and MAP dips predicted bloodstream infection in pediatric patients with burn injuries with 87% accuracy, which may justify its use in resource-poor environments, or in cases where practical supporting evidence is needed for preemptive antibiotic treatment before culture results are available.
718 Indirect Calorimetry is Necessary to Optimize Nutrition in Large Burns
Authors: Srinivas Shruthi , Thomas Sheela S , Cordova Alfredo C , Bernal Nicole O 
Published: March 2022

Abstract

Introduction
Assessing nutritional requirements in large total body surface area (TBSA) burns is a challenge due to frequent metabolic variation. Studies have compared indirect calorimetry (IC) with predictive equations and identified formulas that are frequently used in the absence of IC. Large TBSA burns remain poorly understood, as does the role of changing metabolic rate and multiple surgical procedures over the course of recovery. We sought to understand whether these equations remain reliable in these situations.

Methods
The patient is a 31 year old, 92% full-thickness TBSA burn who was studied over the first 75 days of hospitalization at various points per institutional IC guidelines. Using total energy expenditure (TEE) by IC as the standard, we assessed variation of each predictive equation for accuracy. Only the Milner and Toronto formulas are dynamic, and we analyzed variation by post-burn day (PBD) compared to dates of major surgical procedures in these studies. The patient was excised on PBD 1, 2, 5, 7, 9, 21, and 25; he was grafted on POD 5, 11, 20, 41, and 56. Weekly monitoring of prealbumin and CRP indicated adequate nutrition.

Results
On post-burn day (PBD) 5, when all major burns were excised, all predictive equations inappropriately estimated the patient’s energy expenditure. On longitudinal analysis of 16 IC studies (Table 2), the Milner equation was most accurate, estimating within 5% variance of TEE at 5 time points (31%). The Toronto formula did not estimate within 5% variance at any time point. No energy equation consistently and accurately estimated energy expenditure over all calculated time points.

Conclusions
Although predictive equations are frequently used, in high TBSA burns with many operations and changing nutritional needs, equations are not as accurate as IC. Given that over- or under-estimating needs result in many complications avoided with IC, we propose frequent IC for intubated, high TBSA patients.