bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Variability in Quantitative Traits of Field Pea (Pisum sativum L.) Genotypes at Bekoji District, Ethiopia
Authors: Ertiro Temesgen Abo 
Published: October 2022

For resource-poor Ethiopian farmers, field pea (Pisum sativum L.) is the main source of protein. To increase the productivity of the crop and support farmers, the development of yield and disease-resistant varieties is an important activity. Thus, the purpose of this study was to examine genetic variability and associated agronomic traits among field pea genotypes. A total of 49 field pea genotypes were evaluated at Bekoji in 2020 using a simple lattice design. Analyses of variance were performed on the morpho-agronomic data collected. Most traits were significantly different among genotypes, except pod per plant, pod length, and seed per pod. Variations in genotypes for grain yield ranged from 412 to 4498 kg ha-1. EH 010011-3, EH 05048-5, and EK 08017-3 were the genotypes with the most yield advantage over Bursa (3714.0 kg ha -1), with yield advantages of 21.11, 1.13, and 1.19%, respectively, over the highest yielding check variety. Genotype EH 010011-3 showed the highest mean grain yield of 4498 kg/ha. Phenotypic coefficients of variation ranged from 2.33% for days to maturity to 29.40% for thousand seed weights, whereas genotypic coefficients of variation ranged from 2.20% to 24.31% for days to maturity. In general, the estimated broad sense heritability ranged from 63.85% for harvest index to 89.21% for days to maturity. The genetic advance as a percentage of mean ranged from 4.28% for days to maturity to 42.16% for grain yield. The study showed that field pea genotypes exhibit reasonable genetic variation, which could be used to develop breeding programs.
Clinical Study of Neurodegenerative Treatment on Glaucoma by Insulin Intravitreal Injection
Authors: Boudghene Amine Chaoui 
Published: October 2022

Purpose: Our trail was to study insulin intravitreal injection’s (IIV) efficacity and safety to treat glaucoma neurodegeneration.
Methods: Eleven subjects (11eyes) were recruited;10 patients treated in a double masked randomized sham controlled including 5 patients received one IIV injection 3UI and 5 patients received one injection of balanced salt solution(BSS) 3UI. A follow up during 168days was realized using Optical Coherence Tomography(OCT) and visual field(VF).The eleventh patient received two IIV injection without masking the injection content within one month between each injection and followed up for 877days.All the patients have a correct ocular pressure and no ocular treatment was stopped.
Results: The 5 patients who received IIV revealed a swift improvement of decibel (DB), and remains stable during the first month. The average improvement was 6.62DB during 168days.The 5 patients treated with one BSS injection showed no significant improvement regaining 1. 45DB.The last patient who received two injections showed increase from 7.54DB to 17.22DB with a functional amelioration of 9. 68DB.The OCT examination showed a structural improvement during the first month, then returned to the initial value. No complication was observed during and after the treatment.
Conclusion: Insulin shows not only efficacity and safety but more than that, the visual field(VF) of the patients became stable and show no deterioration in all the follow up, which confirmed that insulin act to improve the function rather than structure. it means insulin reconnect the stoma and improve the neurite outgrowth This treatment will change the evolution of this pathology and protect the glaucomatous patients against blindness.
Preliminary Research Priorities for Factors Influencing Individual Outcomes for Users of the US National Suicide Prevention Lifeline
Authors: Miller Adam Bryant , Oppenheimer Caroline W. , Glenn Catherine R. , Yaros Anna C. 
Published: October 2022

ImportanceSince July 2022, calling or texting 988 in the US connects callers to the National Suicide Prevention Lifeline following a law passed by Congress to simplify access to the mental health crisis line in the US. Compared with other areas of suicide research, knowledge regarding how and to what extent crisis lines prevent suicide crises and suicide deaths remains in its infancy. The state of this research is briefly reviewed and critical directions for future research on factors that may influence effectiveness are suggested.ObservationsThe new 988 line stands to improve access to critical lifesaving measures in the moments of a suicidal crisis. However, urgent questions remain regarding how to improve effectiveness of crisis lines. Available evidence suggests that crisis lines are often effective at reducing immediate distress and reducing suicide risk, but substantial gaps remain in understanding how crisis lines work.Conclusions and RelevanceFuture research is recommended with suicide prevention crisis lines, such as 988, to identify and test factors influencing effectiveness, including conversation, consumer, dyadic, and structural-level characteristics. Existing research, while minimal, suggests that prescription of 988 to prevent suicide death is clinically warranted, but much more work is needed to optimize care.
2D Catalytic, Chemodynamic, and Ferroptotic Vermiculite Nanomedicine
Authors: Ma Lifang , Huang Hui , Feng Wei , Chen Liang , Xia Lili , Yu Yongchun , Wang Jiayi , Chen Yu 
Published: October 2022

AbstractThe emerging chemodynamic therapy employs an iron‐based catalytic Fenton reaction to transform less‐reactive endogenous hydrogen peroxide within the tumor microenvironment (TME) into a highly toxic hydroxyl radical for killing cancer cells. However, the effective deployment of chemodynamic modality remains challenging, mired by a paucity of Fenton agents and overexpressed antioxidant glutathione (GSH) in cancer cells. Herein, a clay‐based 2D vermiculite nanosheet as a self‐reinforcing chemodynamic nanoagent for efficient lung cancer treatment is engineered. The engineered 2D vermiculite nanosheets are not only biocompatible with normal cells but also capable of regulating the TME through depleting GSH, which ameliorates the antioxidant activity of cancer cells. Meanwhile, GSH consumption results in increased intracellular reactive oxygen species content and enhanced lipid peroxidation level, thus inducing ferroptosis and augmenting chemodynamic cell‐killing efficacy. In particular, the ferrous oxidase hephaestin is the direct therapeutic target for 2D vermiculite nanosheets to fight against lung cancer cells. Systematic in vivo evaluations on a xenografted tumor model verify the favorable biosafety and effective tumor suppression capacity of the engineered 2D vermiculite nanosheets‐mediated chemodynamic tumor therapy by inducing desirable ferroptosis. Therefore, the developed vermiculite nanosheets represent the paradigm of 2D ferroptosis‐inducing nanomedicine for synergistic and efficient cancer treatment.
Multiscale Architectured Membranes, Electrodes, and Transport Layers for Next‐Generation Polymer Electrolyte Membrane Fuel Cells
Authors: Jang Segeun , Kang Yun Sik , Kim Dohoon , Park Subin , Seol Changwook , Lee Sungchul , Kim Sang Moon , Yoo Sung Jong 
Published: October 2022

AbstractOver the past few decades, considerable advances have been achieved in polymer electrolyte membrane fuel cells (PEMFCs) based on the development of material technology. Recently, an emerging multiscale architecturing technology covering nanometer, micrometer, and millimeter scales has been regarded as an alternative strategy to overcome the hindrance to achieving high‐performance and reliable PEMFCs. This review summarizes the recent progress in the key components of PEMFCs based on a novel architecture strategy. In the first section, diverse architectural methods for patterning the membrane surface with random, single‐scale, and multiscale structures as well as their efficacy for improving catalyst utilization, charge transport, and water management are discussed. In the subsequent section, the electrode structures designed with 1D and 3D multiscale structures to enable low Pt usage, improve oxygen transport, and achieve high electrode durability are elucidated. Finally, recent advances in the architectured transport layer for improving mass transportation including pore gradient, perforation, and patterned wettability for gas diffusion layer and 3D structured/engineered flow fields are described.
Reservoir Computing with Charge‐Trap Memory Based on a MoS2 Channel for Neuromorphic Engineering
Authors: Farronato Matteo , Mannocci Piergiulio , Melegari Margherita , Ricci Saverio , Compagnoni Christian Monzio , Ielmini Daniele 
Published: October 2022

AbstractNovel memory devices are essential for developing low power, fast, and accurate in‐memory computing and neuromorphic engineering concepts that can compete with the conventional complementary metal−oxide−semiconductor (CMOS) digital processors. 2D semiconductors provide a novel platform for advanced semiconductors with atomic thickness, low‐current operation, and capability of 3D integration. This work presents a charge‐trap memory (CTM) device with a MoS2 channel where memory operation arises, thanks to electron trapping/detrapping at interface states. Transistor operation, memory characteristics, and synaptic potentiation/depression for neuromorphic applications are demonstrated. The CTM device shows outstanding linearity of the potentiation by applied drain pulses of equal amplitude. Finally, pattern recognition is demonstrated by reservoir computing where the input pattern is applied as a stimulation of the MoS2‐based CTMs, while the output current after stimulation is processed by a feedforward readout network. The good accuracy, the low current operation, and the robustness to input random bit flip makes the CTM device a promising technology for future high‐density neuromorphic computing concepts.
Functional Neuroimaging as an Assessment Tool in Critically Ill Patients
Authors: Norton Loretta , Kazazian Karnig , Gofton Teneille , Debicki Derek B. , Fernandez‐Espejo Davinia , Peelle Jonathan E. , Al Thenayan Eyad , Young G. Bryan , Owen Adrian M. 
Published: October 2022

ObjectiveLittle is known about residual cognitive function in the earliest stages of serious brain injury. Functional neuroimaging has yielded valuable diagnostic and prognostic information in chronic disorders of consciousness, such as the vegetative state (also termed unresponsive wakefulness syndrome). The objective of the current study was to determine if functional neuroimaging could be efficacious in the assessment of cognitive function in acute disorders of consciousness, such as coma, where decisions about the withdrawal of life‐sustaining therapies are often made.MethodsA hierarchical functional magnetic resonance imaging (fMRI) approach assessed sound perception, speech perception, language comprehension, and covert command following in 17 critically ill patients admitted to the intensive care unit (ICU).ResultsPreserved auditory function was observed in 15 patients (88%), whereas 5 (29%) also had preserved higher‐order language comprehension. Notably, one patient could willfully modulate his brain activity when instructed to do so, suggesting a level of covert conscious awareness that was entirely inconsistent with his clinical diagnosis at the time of the scan. Across patients, a positive relationship was also observed between fMRI responsivity and the level of functional recovery, such that patients with the greatest functional recovery had neural responses most similar to those observed in healthy control participants.InterpretationThese results suggest that fMRI may provide important diagnostic and prognostic information beyond standard clinical assessment in acutely unresponsive patients, which may aid discussions surrounding the continuation or removal of life‐sustaining therapies during the early post‐injury period. ANN NEUROL 2023;93:131–141
Synthese von α‐Aminosäurederivaten durch hydrative Aminierung von Alkinen
Authors: Feng Minghao , Tinelli Roberto , Meyrelles Ricardo , González Leticia , Maryasin Boris , Maulide Nuno 
Published: October 2022

Abstractα‐Aminosäurederivate sind Kernbestandteile jeglichen Lebens. Die Synthese von α‐Aminocarbonyl/carboxyl Verbindungen ist jedoch weiterhin eine Herausforderung für die organische Synthese. In dieser Arbeit berichten wir von einer praktischen Herstellungsmethode für α‐Aminosäurederivate durch direkte hydrative Aminierung von aktivierten Alkinen mit Sulfinamiden unter milden Bedingungen. Computergestützte Untersuchungen legen nahe, dass eine [2,3]‐sigmatrope Sulfoniumumlagerung der zentrale Schritt der Reaktion ist.
Doping/Alloying Pathways to Lead‐Free Halide Perovskites with Ultimate Photoluminescence Quantum Yields
Authors: Stroyuk Oleksandr , Raievska Oleksandra , Hauch Jens , Brabec Christoph J. 
Published: October 2022

AbstractTailored modifications of halide lead‐free perovskites (LFPs) via doping/alloying with metal cations have been recognized as a promising pathway to highly efficient inorganic phosphors with photoluminescence (PL) quantum yields of up to 100 %. Such materials typically display selective sensitivity to UV light, a broad PL range, and long PL lifetimes as well as a unique compositional variability and stability—an ideal combination for many light‐harvesting applications. This Minireview presents the state‐of‐the‐art in doped LFPs, focusing on the reports published mostly in the last two to three years. We discuss the factors determining the efficiency and spectral parameters of the broadband PL of doped LFPs depending on the dopant and host matrix, both in micro‐ and nanocrystalline states, address the most relevant challenges this rapidly developing research area is facing, and outline the most promising concepts for further progress in this field.
Effects of crystallization temperature and cooling rate on the polymorphism of trans‐1,4‐polyisoprene vulcanizate
Authors: Wang Wenjun , Yu Xinyu , Xia Mingchen , Wang Dongdong , Wu Jinghua , Hu Jian , Yan Shouke , Xue Meiling 
Published: October 2022

AbstractThe effects of crystallization temperature and cooling rate on the polymorphism of trans‐1,4‐polyisoprene vulcanizate (TPI‐V) with different sulfur dosages were monitored by WAXD in real time. The results showed that both the crystallization temperature and the cooling rate play decisive roles in determining the polymorphism and their relative amounts, whereas their effects are interfered by the crosslinking density which restrains the crystallization kinetics. Only α crystal is formed when crystallization is conducted at 40°C or greater and mixed α/β crystals are obtained in the temperature range of 10–30°C. β crystal is predominate when crystallized at 10°C while α crystal is limited at 30°C. Both the lower temperature and increased crosslinking density are beneficial to β crystal formation. A high crosslinking density causes a prolonged time is needed for pure α crystal formation, and hinders the TPI‐Vs from forming pure α crystal even if crystallization is conducted at 45°C. A lower cooling rate favors the formation of α crystal while a higher cooling rate favors β crystal formation. The β spherulites are much brighter than α spherulites under the observation of polarized microscopy.
Gel Electrolyte for Li Metal Battery
Authors: Wu Chen , Zeng Wei 
Published: October 2022

AbstractThe pursuit of high energy density enables lithium metal batteries (LMBs) to become the research hotpot again. However, the safety concerns including easy leakage and inflammability of the liquid electrolyte and the performance deterioration due to the uncontrollable Li dendrites growth in liquid electrolyte limit the further development of LMBs. Gel electrolyte, the most promising alternative for the commercial liquid electrolyte, is expected to solve the dilemma faced by the liquid electrolyte because of its higher safety, good flexibility and adaptability to the electrode and high ionic conductivity comparable to that of liquid electrolyte. Deeply understanding the characteristics and the role of the gel electrolyte in LMBs is of great importance to achieve superior electrochemical performance of LMBs. In this review, we comprehensively introduce the chemical fundamental of the gel electrolyte. On this basis, the modification strategies and the recent progress of the gel electrolyte for LMBs are systematically reviewed and particularly highlighted, which are categorized based on composition regulation, structural design and functional design. We endeavor to provide guidance for the rational design of the gel electrolyte with superior properties for LMBs.
Datenbasiert Energieverbrauch und Raumklima öffentlicher Gebäude verbessern – Literaturstudie mit Fokus auf den Erfolg von Ansätzen
Authors: Bachlechner Daniel , Rader Michael , van Karsbergen Vincent , Pfluger Rainer 
Published: October 2022

AbstractFür das Erreichen der Klimaziele ist die Reduktion des Energiebedarfs von öffentlichen Gebäuden aufgrund ihrer Vorbildwirkung von besonderer Bedeutung. Gleichzeitig sind ein angenehmes Raumklima und unbelastete Innenraumruft für die Behaglichkeit und die Gesundheit der Gebäudenutzer von entscheidender Bedeutung. Rasante Entwicklungen bei Sensoren sowie in den Bereichen Datenanalyse und Simulation haben dazu geführt, dass zunehmend versucht wird, mithilfe von datenbasierten Ansätzen Verbesserungen bei Energieverbrauch und Raumklima zu erzielen. Auch wenn öffentliche Gebäude im Vergleich zu Wohngebäuden im wissenschaftlichen Diskurs eine untergeordnete Rolle spielen, hat die Dynamik zuletzt so stark zugenommen, dass es immer schwieriger wird, den Überblick darüber zu behalten, welche Ansätze in welchen Situationen mit welchem Erfolg angewendet werden. Im vorliegenden Beitrag wird eine Literaturstudie vorgestellt, die sich mit dieser Problematik befasst. Für die Studie wurden 91 von Experten begutachtete Artikel untersucht, die zwischen 2014 und 2022 in wissenschaftlichen Zeitschriften veröffentlicht worden sind. Festgestellt wurde, dass die Bedeutung des Raumklimas bei datenbasierten Ansätzen im Vergleich zu der des Energieverbrauchs zunimmt, gebäudemodellbasierte Simulationen mit zunehmender Häufigkeit eingesetzt werden, sich Artikel mit sehr spezifischen Fragestellungen beschäftigen und eine Ende‐zu‐Ende‐Betrachtung, die auch die Gebäudenutzer berücksichtigt, meist ausbleibt.
Teaching data analysis for building performance simulation – Series: Building simulation and calculation tools in teaching
Authors: Hopfe Christina Johanna , McLeod Robert Scot , Gustin Matej , Brembilla Eleonora , McElroy Lori 
Published: October 2022

AbstractThe Erasmus+ project, entitled ‘Digital Erasmus – a roadmap to using building performance simulation to achieve resilient design’ (DesRes), seeks to transform the learning experience of students in built environment disciplines using a continuous digital learning cycle. Three universities play a part in this project: Graz University of Technology (TU Graz), Delft University of Technology (TU Delft) and the University of Strathclyde (UoS), each developing and delivering a module to complete the learning experience in building simulation. This paper describes the aims and learning objectives associated with the workshops taught at TU Graz as part of the module dedicated to energy monitoring. These workshops tackle the complexity of working with large data sets, which commonly arise from energy monitoring research. In particular, the workshops aim to provide a practical understanding of how to identify, handle, reshape, clean up and evaluate important summary statistics from incomplete data sets. These are fundamental skills in building simulation where model validation and calibration are increasingly commonplace.
Cell growth and the cell cycle: New insights about persistent questions
Authors: Øvrebø Jan Inge , Ma Yiqin , Edgar Bruce A. 
Published: October 2022

AbstractBefore a cell divides into two daughter cells, it typically doubles not only its DNA, but also its mass. Numerous studies in cells ranging from yeast to mammals have shown that cellular growth, stimulated by nutrients and/or growth factor signaling, is a prerequisite for cell cycle progression in most types of cells. The textbook view of growth‐regulated cell cycles is that growth signaling activates the transcription of G1 Cyclin genes to induce cell proliferation, and also stimulates anabolic metabolism and cell growth in parallel. However, genetic knockout tests in model organisms indicate that this is not the whole story, and new studies show that additional, “smarter” mechanisms help to coordinate the cell cycle with growth itself. Here we summarize recent advances in this field, and discuss current models in which growth signaling regulates cell proliferation by targeting core cell cycle regulators via non‐transcriptional mechanisms.
The impact of modifications in cadaver dissection time on student learning outcomes in a doctor of physical therapy program
Authors: Donovan Skye , Negley Kelly J. , Moran Megan W. , Craig PT Jason A. 
Published: October 2022

AbstractHuman anatomy is a foundational component of medical and allied health professional education. Doctor of Physical Therapy (DPT) programs are required to teach anatomy, however the pedagogies used are at the discretion of faculty and institutions. Cadaver dissection may have been the predominant instruction methodology in DPT programs in the past; new technology provides alternative interactive teaching methods. This paper describes the modifications in an anatomy curriculum over 5 years in one DPT program, and the impact on student perception and learning outcomes. This was a retrospective, quantitative study that utilized a survey to collect data on student perceptions about the anatomy pedagogy; the learning outcomes analyzed were grades and licensure exam pass rates. We report on outcomes for five cohorts within one DPT program. IRB approval was obtained for the research. Despite the decrease in cadaver laboratory time after 2016, students' final exam grades in Gross Anatomy improved and the first time pass rate for the national licensure exam increased. Most students rated cadaver laboratory and the active learning assignments that replaced traditional cadaver laboratory time as valuable to their learning; however, there were differences in opinions between cohorts. Although the outcomes might not reflect a direct result of dissection time, the study confirmed that using alternative methods for teaching anatomy did not hinder student performance. Using innovative pedagogy allows educators to achieve student success in spite of decreased gross dissection time.
Divergent Copper‐salt‐controlled Reactions of Donor‐Acceptor Cyclopropanes and N‐Fluorobenzene Sulfonimide: Access to the 1,3‐Haloamines and Aminoindanes
Authors: Liu Lingyan , Wang Xiao , Xiao Weiguo , Chang Weixing , Li Jing 
Published: October 2022

AbstractWe herein report a method for divergent copper salt controlled reactions of donor‐acceptor cyclopropanes and N‐fluorobenzene sulfonimide (NFSI). Specifically, in the presence of CuX2 (X=Cl, Br), the cyclopropanes underwent formal umpolung 1,3‐aminohalogenation bifunctionalization via a free radical mediated ring‐opening process to afford 1,3‐aminochlorination and 1,3‐aminobromination products in moderate to good yields. In addition, by using CuI as a catalyst, we synthesized various aminoindane derivatives via 1,3‐aminoarylation cyclization of D‐A cyclopropanes, the reactions involved a free radical mediated ring‐opening and subsequent ring expansion via C−H bond activation.