bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognosis in asymptomatic patients with discordantly graded aortic valve stenosis based on pressure recovery adjusted valve area
Authors: Bahlmann Edda , Einarsen Eigir , Cramariuc Dana , Pedersen Eva R , Rossebø Anne B , Midtbø Helga , Willems Stephan , Gerdts Eva 
Published: November 2022

ObjectiveWe hypothesised that patients with asymptomatic aortic stenosis (AS) who remain with discordantly graded aortic valve stenosis (DGAS) after adjustment for pressure recovery in the aortic root represents a subgroup of patients with increased cardiovascular risk.MethodsData from 1353 patients with asymptomatic mild–moderate AS and preserved left ventricular ejection fraction enrolled in the Simvastatin and Ezetimibe in AS study was used. DGAS was identified as combined pressure adjusted valve area (energy loss) <1.0 cm² and mean aortic gradient<40 mm Hg (DGASEL). Outcome was assessed in Cox regression analysis and reported as HR and 95% CI.ResultsDGASELwas found in 196 (14.5%) patients at baseline, and was associated with older age, female sex, smaller aortic annulus diameter, lower heart rate, more extensive valve calcification and low flow (all p<0.05). In Cox regression analysis, DGASELwas associated with higher rate of heart failure (HF) hospitalisation (HR 3.31 (95% CI 1.54 to 7.09)), cardiovascular death (HR 2.63 (95% CI 1.34 to 5.17)) and all-cause mortality (HR 1.73 (95% CI 1.04 to 2.87)) independent of confounders including low flow and aortic valve calcification (all p<0.05).ConclusionsPatients with asymptomatic AS who remain with discordant grading after adjustment for pressure recovery have increased risk for HF and death.Trial registration numberNCT00092677.
Caledonian hot zone magmatism in the ‘Newer Granites’: insight from the Cluanie and Clunes plutons, Northern Scottish Highlands
Authors: Milne Eilidh J. M. , Neill Iain , Bird Anna F. , Millar Ian L. , McDonald Iain , Dempsey Edward D. , Olive Valerie , Odling Nic , Waters Emma C. 
Published: November 2022

Scottish ‘Newer Granites’ record the evolution of the Caledonides resulting from Iapetus subduction and slab breakoff during the Silurian–Devonian Scandian Orogeny, but relationships between geodynamics, petrogenesis and emplacement are incomplete. Laser ablation U–Pb results from magmatic zircons at the Cluanie Pluton (Northern Highlands) identify clusters of concordant Silurian data points. A cluster with a weighted mean
206
Pb/
238
U age of 431.6 ± 1.3 Ma (2

σ

confidence interval,
n
= 6) records emplacement whilst older points (clustered at 441.8 ± 2.3 Ma,
n
= 9) record deep crustal hot zone magmatism prior to ascent. The Cluanie Pluton, and its neighbour the
c.
428 Ma Clunes tonalite, have adakite-like high Na, Sr/Y, La/Yb and low Mg, Ni and Cr characteristics, and lack mafic facies common in other ‘Newer Granites’. These geochemical signatures indicate the tapping of batches of homogenized, evolved magma from the deeper crust. The emplacement age of the Cluanie Pluton confirms volumetrically modest subduction-related magmatism occurred beneath the Northern Highlands before slab breakoff, probably restricted by crustal thickening during the
c.
450 Ma Grampian 2 event. Extensive new
in situ
geochemical–geochronological studies for this terrane may further substantiate the deep crustal hot zone model and the association between Caledonian magmatism and potentially metallogenesis. The term ‘Newer Granites’ is outdated as it ignores geochronology, petrography and tectonic setting. Hence, ‘Caledonian intrusions’ would be a more appropriate generic term to cover those bodies related to either Iapetus subduction or to slab breakoff.

Supplementary material:
Full geochronological, whole rock geochemical and geobarometric data are available at
https://doi.org/10.6084/m9.figshare.c.6305927
Penalty Default Rules in French, German and Louisianan Contract Law
Authors: Goldford Zackary 
Published: November 2022

Abstract
Some American law and economics scholars have used the term “penalty default rules” to describe default rules that are undesirable to at least one party to a contract. Parties have incentives to depart from these default rules and to share information in doing so. In a recent article, I brought this concept outside of the United States, the common law tradition and the law and economics literature by using it to describe a selection of rules in Québec contract law. In this article, I build on that work by identifying a selection of penalty default rules in three other civilian jurisdictions – France, Germany and Louisiana – that apply to contract formation, contract interpretation, changed circumstances and remedies for breach. Then, I argue that the penalty default rules that I have identified serve two valuable functions. First, they enhance at least some parties’ freedom of contract by better equipping them to make informed decisions. Second, they complement the duty of good faith by incentivizing the sharing of information, including information that might not always need to be shared in order to comply with the duty of good faith. Although these functions are somewhat different than those that law and economics scholars have attributed to American penalty default rules, my analysis reveals that penalty default rules both exist and have value in the civilian world.
Biocompatible phospholipid-based mixed micelles for posaconazole ocular delivery: Development, characterization, and in - vitro antifungal activity
Authors: Osouli Mahraz , Abdollahizad Erfan , Alavi Sonia , Mahboubi Arash , Abbasian Zahra , Haeri Azadeh , Dadashzadeh Simin 
Published: November 2022

Current study intended to prepare and evaluate phospholipid-based, mixed micelles (MMs) to improve the ocular delivery of posaconazole (POS), a broad-spectrum antifungal drug. For this, MMs based on egg phosphatidylcholine (EPC), as the main component, in combination with various bile salts (sodium cholate (NaC), sodium deoxycholate (NaDC), sodium taurocholate (NaTC)) or non-ionic surfactants (Pluronic® F-127, Pluronic® F-68, Tween 80, Labrasol® ALF, and d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS)) were prepared. Particle size, polydispersity index, zeta potential and entrapment efficiency were evaluated to optimize the composition and preparation method of the MMs. Finally, morphology, stability, in vitro release pattern, and in vitro antifungal activity of the optimized formulation were investigated. Among the prepared MMs, vesicles composed of EPC: TPGS with a molar ratio of 70:30, prepared by the thin-film hydration method, showed more appropriate features. Among the prepared MMs, vesicles composed of EPC: TPGS with a molar ratio of 70:30 showed more appropriate features, including an entrapment efficiency (EE) greater than 80%, spherical shape morphology, an average particle size of about 58 nm, desirable stability over a month, slow-release without a noticeable initial burst, and a significantly higher in vitro antifungal activity in comparison with the drug suspension. Therefore, this formulation was selected as the optimal MMs and could be considered as a promising carrier for topical ocular delivery of POS.
Experiences of community pharmacists administering COVID-19 vaccinations: A qualitative study
Authors: Gerges Sandra , Gudzak Victoria , Bowles Susan , Logeman Charlotte , Fadaleh Sarah Abu , Bucci Lucie M. , Taddio Anna 
Published: November 2022

Background: Throughout the COVID-19 pandemic, community pharmacists have played an important role in the provision of patient care, including the delivery of COVID-19 vaccines. The additional workload and related demands arising from these extended services might affect worklife burnout. This qualitative study explored the experiences of Canadian community pharmacists in providing COVID-19 vaccines during the COVID-19 pandemic. Methods: Eighteen community pharmacists across 10 provinces were asked about vaccination processes and perceptions about their role in separate, virtual semistructured interviews. Interviews were transcribed verbatim and analyzed using a deductive approach using the Areas of Worklife Burnout framework, with pharmacists’ self-reported descriptions of their activities summarized using the Association of Faculties of Pharmacy of Canada’s (AFPC) professional competencies framework. Results: Participants identified aspects of their role that were rewarding and challenging. Some challenges included lack of control, increased workload, inadequate communication, unfair treatment and conflicting values. They described being able to meet challenges and demonstrating resiliency via adaptability, developing communities and valuing their contribution to ending the COVID-19 pandemic. Self-identified AFPC competencies contributing to their ability to manage their worklife included care-provider, professional, leader-manager, collaborator and scholar. Conclusion: Pharmacists accepted their additional responsibility of managing COVID-19 vaccines during the COVID-19 pandemic. However, they expressed some challenges with this role. To ensure sustainability of these services, prioritizing adequate resources, work processes and efficient communication with all relevant stakeholder groups, including public health, government and corporate leaders, is recommended for the future. Can Pharm J (Ott) 2023;156(Suppl):xx-xx.
Incidence of Olfactory Dysfunction in Patients with COVID-19 in a Tertiary Hospital in Saudi Arabia
Authors: Alfallaj Rayan , AlSkait Ghada , Alamari Nouf , Alfawzan Lama , Abualgasem Mohammed , Alotaibi Naif H. , Sumaily Ibrahim , Alarifi Ibrahim , Alsaleh Saad 
Published: November 2022

Background Coronavirus disease (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2, a novel virus that emerged in China in December 2019. In many cases of COVID-19, olfactory dysfunction (OD) is the only symptom. Objectives This study aimed to examine the incidence of OD in patients with COVID-19 and identify an association between OD and COVID-19-related morbidity and admission. Design This was a cross-sectional study. Methods Real-time reverse transcription polymerase chain reaction-confirmed cases of COVID-19 from the Security Forces Hospital electronic registry from June 2020 to September 2020 were included in our study. Data on medical background, severity of the disease, and other related factors were collected through phone calls and electronic healthcare systems and analyzed to investigate OD in the participants. Results Of the participants, 68% had OD, with a mean recovery time of 18 days and a mean follow-up time of 129 days (76-211 days). OD was negatively correlated with admission and morbidity. Conclusion OD is a common presentation of COVID-19 and is more prevalent in mild cases of infection.
Boosting vegetation, biochemical constituents, grain yield and anti-cancer performance of cultivated oat (Avena sativa L) in calcareous soil using oat extracts coated inside nanocarriers
Authors: Mahmoud Noura E. , Mahdi Asmaa A. , Barakat Ashraf M. A. , Abdelhameed Reda M. 
Published: November 2022

AbstractCalcareous soil contains many problems such as the lack of sources of major and minor elements that are useful for plant growth and development. Plant extracts and nanoparticles are very popular as biostimulants in plant production. Here, the effect of aqueous, non-aqueous and alcoholic oat extracts on the growth, biochemical response of oats leaves and grains grown in experimental fields under new reclamation lands were studied. Moreover, different oat extracts were a pathway through the copper-dependent metal–organic framework (MOFs) to separate bioactive molecules from extracts such as salicylic acid, anthraquinone, and triacylglycerol. Additionally, the separated molecules incorporated in Cu-BTC MOFs and oats extracts missed active molecules were spray applied on oat plants. The results showed that the treated plants showed stimulatory responses in growth and physiology. The treatments improved plant growth and biomass, enhanced total protein, water-soluble carbohydrates, free phenolic compounds content in oat leaves, photosynthesis, and chlorophyll contents. The treatments also improved the level of vitamins E and K, phenolic compounds, and avenanthramides C in the oat grains. Moreover, the treatments showed an improvement in the yield of oats (grain and straw) using water and alcoholic oat extracts in which the active molecules were missed. Our findings demonstrate that Cu-BTC and oats extracts can act as a biostimulant to enhance the biological and chemical properties of oats and increase the yield in calcareous soils. The cytotoxicity study of oats (produced from AE, c@Cu-BTC, and AE-c treatments) was conducted using Vero Cell lines. The anticancer activities of different oat grains were carried out using MCF 7cell lines. The results show that the grains produced from the AE, c@Cu-BTC, and AE-c treatments possessed 94.3, 72.3, and 100% activity towards the cancer cell line. Removal of growth inhibitors from spray solutions increases grain yield and anticancer activity.
A simple APACHE IV risk dynamic nomogram that incorporates early admitted lactate for the initial assessment of 28-day mortality in critically ill patients with acute myocardial infarction
Authors: Song Jikai , Yu Tianhang , Yan Qiqi , Wu Liuyang , Li Sujing , Wang Lihong 
Published: November 2022

AbstractBackgroundEarly risk stratification is important for patients with acute myocardial infarction (AMI). We aimed to develop a simple APACHE IV dynamic nomogram, combined with easily available clinical parameters within 24 h of admission, thus improving its predictive power to assess the risk of mortality at 28 days.MethodsClinical information on AMI patients was extracted from the eICU database v2.0. A preliminary XGBoost examination of the degree of association between all variables in the database and 28-day mortality was conducted. Univariate and multivariate logistic regression analysis were used to perform screening of variables. Based on the multifactorial analysis, a dynamic nomogram predicting 28-day mortality in these patients was developed. To cope with missing data in records with missing variables, we applied the multiple imputation method. Predictive models are evaluated in three main areas, namely discrimination, calibration, and clinical validity. The discrimination is mainly represented by the area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI) and integrated discrimination improvement (IDI). Calibration is represented by the calibration plot. Clinical validity is represented by the decision curve analysis (DCA) curve.ResultsA total of 504 people were included in the study. All 504 people were used to build the predictive model, and the internal validation model used a 500-bootstrap method. Multivariate analysis showed that four variables, APACHE IV, the first sample of admission lactate, prior atrial fibrillation (AF), and gender, were included in the nomogram as independent predictors of 28-day mortality in AMI. The prediction model had an AUC of 0.819 (95%CI 0.770–0.868) whereas the internal validation model had an AUC of 0.814 (95%CI 0.765–0.860). Calibration and DCA curves indicated that the dynamic nomogram in this study were reflective of real-world conditions and could be applied clinically. The predictive model composed of these four variables outperformed a single APACHE IV in terms of NRI and IDI. The NRI was 16.4% (95% CI: 6.1–26.8%;p = 0.0019) and the IDI was 16.4% (95% CI: 6.0–26.8%;p = 0.0020). Lactate accounted for nearly half of the total NRI, which showed that lactate was the most important of the other three variables.ConclusionThe prediction model constructed by APACHE IV in combination with the first sample of admission lactate, prior AF, and gender outperformed the APACHE IV scoring system alone in predicting 28-day mortality in AMI. The prediction dynamic nomogram model was published via a website app, allowing clinicians to improve the predictive efficacy of the APACHE IV score by 16.4% in less than 1 min.
Microbiological and clinical characteristics of invasive Group B Streptococcal blood stream infections in children and adults from Qatar
Authors: Ali Maisa , Alamin Mohammed A. , A. Ali Gawahir , Alzubaidi Khalid , Ali Bashir , Ismail Abdellatif , Daghfal Joanne , Almaslamani Muna , Hadi Hamad Abdel 
Published: November 2022

Abstract
Introduction
Group B Streptococci (GBS) colonize almost one third of human gastrointestinal and genitourinary tracts, particularly in females. The aim of this study is to evaluate the epidemiology, microbiological characteristics, and clinical outcomes of invasive GBS disease in Qatar from all age groups.

Methods
A retrospective study was conducted on patients with confirmed GBS blood stream infections during the period between January 2015 and March 2019. Microbiological identification was performed using automated BD PhoenixTM system, while additional antimicrobial susceptibility tests were performed using E test and disc diffusion methods.

Result
During the four years period, the incidence steadily rose from 1.48 to 2.09 cases per 100.000 population. Out of 196 confirmed cases of invasive GBS infections, the majority were females (63.7%, 125/196) of which 44.8% were pregnant and 53.6% were colonized. Three distinct affected age groups were identified: children ≤ 4 years of age (35.7%), young adults 25–34 (20.9%) and the elderly ≥ 65 year (17.4%). Presenting symptoms were mild with fever in 53% of cases while 89% of cases had Pitt bacteraemia score of ≤ 2. Isolates were universally sensitive to penicillin, ceftriaxone, and vancomycin at 100% but with significant resistance to erythromycin (49%) and clindamycin (28.6%) while 16.8% had inducible clindamycin resistance. Clinical outcomes showed cure rate of 87.25% with complications in (8.76%) and 4% mortality.

Conclusion
There is a rising trend of Group B Streptococcal blood stream infections in Qatar with significantly high clindamycin and erythromycin resistance rates. Universal susceptibility rates were demonstrated for penicillin, ceftriaxone, and vancomycin.
A comparison of the utility of the urine dipstick and urine protein-to-creatinine ratio for predicting microalbuminuria in patients with non-diabetic lifestyle-related diseases -a comparison with diabetes
Authors: Ogi Makoto , Seto Takuya , Wakabayashi Yoshinori 
Published: November 2022

Abstract
Background
The utility of dipstick proteinuria for predicting microalbuminuria in non-diabetic lifestyle-related diseases compared with the urine protein-to-creatinine ratio (uPCR) and the effect of dipstick proteinuria on the cut-off value (CO) and accuracy of uPCR are unclear.

Methods
The subjects included Japanese patients ≥ 18 years old with lifestyle-related diseases who had an estimated glomerular filtration rate of ≥ 15 ml/min/1.73 m2 and uPCR of < 0.5 g/gCr at initiation. Urine dipstick, uPCR and urine albumin-to-creatinine ratio (uACR) were measured three times per case. Microalbuminuria was defined as uACR of 30–299 mg/gCr for at least 2 of 3 measurements. Youden’s Index was used as the optimal CO. Factors associated with microalbuminuria were analyzed using a logistic regression model.

Results
In 313 non-diabetic cases (median 70.8 years old), 3 dipstick proteinuria measurements were independently useful for detecting microalbuminuria, and the CO was set when a trace finding was obtained at least 1 of 3 times (sensitivity 0.56, specificity 0.80, positive predictive value [PPV] 0.73, negative predictive value [NPV] 0.65). A single uPCR measurement was more useful than 3 dipstick measurements, and was useful for detecting microalbuminuria even in cases with three consecutive negative proteinuria findings, indicating that the CO of the second uPCR with G1-3a (n = 136) was 0.06 g/gCr (sensitivity 0.76, specificity 0.84. PPV 0.68, NPV 0.89), while that with G3-b4 (n = 59) was 0.10 g/gCr (sensitivity 0.56, specificity 0.91. PPV 0.83, NPV 0.71). The sum of 3 uPCRs was useful for detecting microalbuminuria in cases with G1-3a (sensitivity 0.67, specificity 0.94, PPV 0.82, NPV 0.86) and G3b-4 (sensitivity 0.78, specificity 0.94, PPV 0.91 NPV 0.83), with both COs being 0.23 g/gCr. These COs of microalbuminuria did not change when trace or more proteinuria was included, although the sensitivity increased. A high uPCR and low urine specific gravity or creatinine level were independent factors for uACR ≥ 30 mg/gCr in cases with negative proteinuria, although the uPCR was a major predictive factor of a uACR ≥ 30 mg/gCr.

Conclusions
The uPCR (preferably determined using early-morning urine), including in dipstick-negative proteinuria cases with non-diabetic lifestyle-related diseases, can aid in the early detection of microalbuminuria.

Trial registration
Retrospectively registered.
Influence of preventive sex education programmes in compulsory secondary education students: a descriptive observational study
Authors: Berutich Arturo Hidalgo , Cortes María Barbosa , Feria Esther Cárdenas , Rufete Margarita Carrillo , González Miguel Pedregal , Razquin Eduardo Perez , Arcos Esteban Delgado 
Published: November 2022

Abstract
Background
Sex education programmes conducted by health professionals and educators are essential for young people to adopt healthy habits and attitudes towards their sexuality. The Forma Joven Program, promoted by the Andalusian Regional Government’s Ministry of Health and Families and Education, is a good example of this. The aim of the study is to determine if different “degrees of intervention” in the informative consultancies of the Forma Joven Program imply differences in knowledge and attitudes towards sexuality.

Methods
This descriptive observational study analysed 27 Compulsory Secondary Education high schools in Huelva. These were included in the Program and belonged to a Primary Care Health District. Out of the 17 institutes initially selected because they met the inclusion criteria (4.256 students), finally 14 (3.596 students) participated. During the 2018/2019 school year, students from 3rd, 4th year of Secondary Compulsory Education (ESO), 1st, and 2nd Baccalaureate of the selected centres were asked to fill in a questionnaire of knowledge and attitudes towards sexuality. It collected variables such as age, sex, school year, institute, educational level and employment status of the father or mother and profile of the professional who delivers the counselling.

Results
A total of 1.237 students completed the questionnaire, which represents a participation rate of 34.4%. The average age was 15.59 years (SD 1.26) and 39.9% were girls. In some evaluated questions, we found statistically significant differences between the groups with different levels of exposure to counselling and the acquisition of knowledge and attitudes towards students’ sexuality, although in most of them no such differences were found. The results of this study suggest the importance of the quality of counselling over quantity. Some classic myths persist in relation to sexuality and in some situations, they can be decisive when adopting preventive measures to avoid risks related to pregnancy and contagion of STIs.

Conclusions
A greater number of counselling sessions does not imply acquiring a higher level of knowledge or better attitudes towards sexuality. Perhaps the quality of the education is more important than the quantity of counselling sessions.