bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metatarsal Stress Fractures: An Analysis of Readability and Quality of Online Health Materials
Authors: Hickey Olivia , Murphy Ben , Kiroplis Irene , Hidayat Yasir , D’Souza Lester 
Published: October 2022

Abstract
Background
Patients are increasingly accessing health information via the internet. Our aim was to assess the quality and readability of online patient education materials regarding metatarsal stress fractures. We hypothesised that this information would be too difficult for the average patient to read and of a lesser quality than desired.
Method
A search of the top 50 results on 3 search engines (Google, Bing, Baidu) was completed (MeSH “metatarsal stress fracture”, “metatarsal stress fractures”). Readability of these websites was calculated using www.readable.com, producing 3 scores: Gunning-Fog (GF), Flesch Reading Ease (FRE) and Flesch-Kincaid Grade (FKG). Quality of the retrieved webpages was analyzed using Journal of American Medical Association (JAMA) benchmark criteria and the Health On the Net (HON) code toolbar extension.
Results
77 unique websites were identified. The mean scores were: FRE 56.34+/- 16.1, FKG 8.36 +/- 2.8 and GF 9.35 +/-3.4. This corresponds with most webpages being pitched to a grade 8–12 reading level. Most webpages per the FRE score (n = 47, 61%) were pitched at a grade 10 reading level and above. The GF index identified 20 webpages (26%) aimed towards readers of a grade 7 level or below. 10 websites (13%) displayed a current HONcode certificate. Most websites (n = 35, 45.5%) didn’t meet any of the JAMA criteria.
Conclusion
This study uncovers the high difficulty and poor quality of online health materials relating to MSFs, potentially contributing to negative health outcomes. Given the relationship of health literacy and patient outcomes, it is vital that we address these deficiencies swiftly.
Community awareness, attitudes and patterns of use toward fish oil and cod liver oil in Ethiopia: A cross-sectional study
Authors: Sasie Sileshi Demelash , Abayneh Aschalew , Wodajo Berhanu , Kebede Mebratu Abraha , Aragaw Fantu Mamo 
Published: October 2022

Abstract
Background
- Nutrition has a significant impact on health throughout life. Despite the increased frequency of questions about dietary supplements and their availability, reports showed that the communities have little knowledge of dietary supplements. Fish oils and cod liver oil is the most widely used non-vitamin, non-mineral dietary supplements. The present study aimed to determine the knowledge, attitudes, and practice of the community towards dietary supplements such as fish oil and cod liver oil including some underlying factors in Ethiopia.
Method
- A cross-sectional multi-center study was conducted among the community in different cities of Ethiopia. Stratified random sampling was used to select a total of 900 community participants included in the study. The data was collected using an interview-administered questionnaire. Descriptive analysis was done using STATA software. Both bi-variable and multivariable logistic regression analysis was done.
Results
The overall knowledge, attitude, and practice of the community towards the usage of cod-liver oil or fish oil in this study was 65.04%, 62.26%, and 26.75% respectively. Participants living in Sidama and Oromo have 0.25 (AOR = 0.25:,95% CI: 0.07, 0.90) and 0.23 (AOR = 0.23:,95% CI: 0.06, 0.88), having an income level of < 3000 have 0.56 (AOR = 0.56:,95% CI: 0.30, 0.98) ) times higher odds of being knowledgable towards cod-liver oil and fish oil. Participants who have chronic illness were 3.27 (AOR = 3.27; 95% CI; 1.71, 6.23), times higher odds of practicing usage of cod-liver oil or fish oil than participants who have no chronic illness. Participants who were aged > 45 were 0.27 (AOR = 0.27; 95% CI; 0.06, 0.90), times higher odd of practicing usage of cod-liver oil or fish oil
Conclusion
The overall knowledge and attitude of the community were good, but their practice towards the usage of cod liver or fish oil was relatively low. Participants living in Sidama and Oromo and having an income level of < 3000 were significant predictors of knowledge of the community using cod-liver oil or fish oil. Participants living in Sidama and Oromo is one of the determinant factors for having a positive attitude towards the usage of cod-liver oil or fish oil. Participants who were aged > 45, and participants who have chronic illnesses were significant predictors of the practice of the community using cod-liver oil or fish oil.
Multiresolution approach on Medical Image Fusion by Modified Local Energy
Authors: Nair Rekha R , Babu Tina 
Published: October 2022

Abstract
Human and machine perception data that are not redundant are very important in the medical field for diagnosis and treatment. The proposed work fuses medical images to extract valuable necessary information from dissimilar images to a single image in the Wavelet domain using a novel Modified Local Energy(MLE) fusion rule termed ModifiedLocal Energy Image Fusion(MLEIF). The image edges are essential information points that are used to display a clear visual image structure. Modified Local energy helps to provide edge characteristics more clearly in the fusion outcome than a single pixel-based fusion rule. The denoising property of the local energy is the additional advantage of the proposed fusion. The similarity of the fused image with the source images is improved by B-Spline registration in the pre-processing stage. Finally, the fused image is created with all the corresponding coefficients by transforming the inverse wavelet. SVM-based contouring of the lesion part helps observes to identify the lesion part from the fused image. Carried out experiments on real-time and standard data sets with expert radiologist subjective evaluation and quantitative analysis by well-known non-reference performance measures.
Rotation and heat convection effects on double-diffusive peristaltic MHD Sisko nanofluid flow through a porous medium in presence of non-linear thermal radiation, heat generation/absorption, and Joule heating
Authors: Abo-Dahab S. M. , Mohamed R. A. , Abd-Alla A. M. , Soliman M. S. 
Published: October 2022

Abstract
This article includes a numerical study of the double-diffusive peristaltic flow of a non-Newtonian Sisko nanofluid through a porous medium inside a horizontal symmetric flexible channel under the influence of Joule heating, nonlinear thermal radiation, viscous dissipation, and heat generation/absorption in presence of heat and mass convection, considering effects of the Brownian motion and the thermophoresis coefficients. On the other side, the long wave approximation was used to transform the nonlinear system of partial differential equations into the nonlinear system of ordinary differential equations which were later solved numerically using the fourth-order Runge-Kutta method with shooting technique using MATLAB program code. The effects of all physical parameters resulting from this study on the distributions of velocity, temperature, solutal concentration, and nanoparticles volume fraction inside the fluid were studied in addition to, a study of the pressure gradients using the 2D and 3D graphs that were made by the MATLAB program in addition to, studying the impact of some parameters on the behavior of the streamlines graphically within the channel with a mention of their physical meaning. Finally, some of the results of this study showed that the effect of Darcy number 𝐷𝑎 and the magnetic field parameter 𝑀 is opposite to the effect of the rotation parameter 𝛺 on the velocity distribution whereas, the two parameters non-linear thermal radiation𝑅and the ratio temperature 𝜃𝑤works on a decrease in the temperature distribution and an increase in both the solutal concentration distribution and the nanoparticle's volume fraction. On the other hand, the effect of the rotation parameter 𝛺 on the distribution of pressure gradients was positive, and the effect of both Darcy number 𝐷𝑎 and the magnetic field parameter 𝑀on the same distribution was negative.
Real-Time Process Evaluation of a Participatory Intervention with Healthcare Workers
Authors: Chin Winnie Szu Yun , Rice Serena , Morocho Cesar , Kurowski Alicia , Punnett Laura 
Published: October 2022

Abstract
Background

Participatory organizational interventions engage workers to improve their own workplace health and safety. Process evaluation helps to avoid expensive missteps and to explicate how and why these interventions succeed or fail. Periodic measurements of attendance and time devoted to program activities are component measures of intervention dose. Participant appraisals of the process (usability) can detect problems and facilitate improvements in real time. This study describes process metrics to evaluate intervention dose, reach and usability in a participatory workplace change study.

Methods

The “Safety and Health through Integrated Teams” (SHIFT) study used a stepped-wedge design in five healthcare facilities, randomized into immediate- and lagged- intervention groups. Joint labor-management health and safety “Design Teams” (DT) were recruited at each site. Immediate intervention sites were coached to use the Healthy Workplace Participatory Program (HWPP): conduct root cause analysis of a health or safety problem, brainstorm solutions, and compile them into intervention packages. At all sites, we tracked attendance and time in meetings of DTs, co-facilitators with the coach, and leadership Steering Committees; participants’ opinions of meetings and program materials; and program activities with time spent outside of meetings.

Results

During the coached period, average attendance at all meetings was 74% of expected individuals per meeting (n = 90), while the uncoached meetings (n = 12) averaged 57%. Across the study period (both uncoached and coached meetings), most DT members reported understanding the meeting purpose, speaking up and having their opinions considered, that facilitators were effective, and discussion was meaningful for health and safety goals. Co-facilitators in the coached period, compared to the uncoached period, reported not enough time during phase 1 (p = 0.053) and more difficulty facilitating later implementation steps (phase 2) than the initial ones (phase 1) (p = 0.029). As the implementation advanced, DT members reported speaking up and giving their opinion more in phase 2 than phase 1 (p = 0.009).

Conclusions

The SHIFT intervention coaching appeared to support high meeting attendance, equal participation and consideration of opinions between managerial and non-managerial personnel. Recording of process outcomes throughout the intervention process helped to identify steps where Design Teams needed assistance, which was essential for a successful participatory program.
Trial registration: ClinicalTrials.gov NCT04251429 (retrospectively registered January 29, 2020).
The novel fluorescent probe toward yttrium(Ⅲ) and its bioimaging
Authors: Qin Yuxin , Meng Qian , Yao Junxiong , Chen Mengyu , Dong Yajie , Chen Dashuo , He Shuping , Bai Cuibing , Zhang Lin , Wei Biao , Miao Hui , Qu Changqing , Qiao Rui 
Published: October 2022

Abstract
In this paper, the novel fluorescence probe XP based on Schiff-base was designed, synthesized and characterized, which could detect Y3+selectively and sensitively. The recognition mechanism of XP toward Y3+ was studied by Job's plot and HRMS. It was investigated that stoichiometric ratio of the probe XP conjugated with Y3+ was 1:2. And the detection limit was calculated as 0.30 µM. In addition, Y3+ was recognized by the test paper made from XP. And the probe XP could selectivity toward Y3+ in Caenorhabditis elegans and the main organs of mice. Thus, XP was considered to have some potential for application in bioimaging.
On the stability &amp; phase locking to a system reference of an optoelectronic oscillator with large delay
Authors: Hasan Mehedi , Nicholls Charles , Hall Trevor 
Published: October 2022

Abstract
Delay line oscillators based on photonic components, offer the potential for realization of phase noise levels up to 3 orders of magnitude lower than achievable by conventional microwave sources. Fibreoptic-based delay lines can realize the large delay required for low phase noise systems whilst simultaneously achieving insertion loss levels that can be compensated with available microwave and photonic amplification technologies. Multimode operation is an artefact of the delay line oscillator and introduces modulational instability into phase-locked control loops. An optoelectronic oscillator (OEO) with large delay under proportional integral control by a phase-locked loop (PLL) is modelled, providing the first report of the location of all the infinity of poles of the PLL-OEO system function. The first experimental observation of giant phase modulated oscillation of a free OEO and spontaneous giant phase modulated oscillation of a PLL-OEO are also reported and explained respectively as a source and manifestation of modulational instability. Nevertheless, the analysis and experimental observations, including a prototype 10 GHz PLL-OEO phase noise spectral density achieving −𝟖𝟎 𝒅𝑩𝒄⁄𝑯𝒛 𝐚𝐭 𝟏𝟎 𝑯𝒛 and −𝟏𝟒𝟓 𝒅𝑩𝒄⁄𝑯𝒛 𝐚𝐭 𝟏𝟎 𝒌𝑯𝒛, demonstrate that stable phase lock operation and optimum phase noise performance is achievable provided full account of the multimode nature of the OEO is taken in the phase lock analysis.
Psoriasis and oral health in adult United Statues population: A cross-sectional study
Authors: Hussein Mai , Farag Youssef M.K. , Sonis Stephen 
Published: October 2022

Abstract
Objectives
The results were inconsistent with the association between psoriasis and periodontitis. To better understand the strength and nature of the association between oral conditions and psoriasis by analysis of a large number of adults in the United States.
Methods
By using The National Health and Nutrition Examination Survey datasets from 2009 to 2014, we performed a cross-sectional analysis. For participants aged ≥ 30 years, the psoriasis status was assessed from the medical questionnaire. We used data from periodontal and oral examinations to assess the oral conditions of our participants. We examined the association between psoriasis as exposure and moderate/severe periodontitis and non-functional dentition as outcomes.
Results
The weighted prevalence of psoriasis was 3%, 44% for moderate/severe periodontitis, and 20.5% for non-functional dentition. The fully adjusted model showed no significant association between psoriasis and moderate/severe periodontitis (Prevalence Ratio 1.03, 95% CI 0.9–1.2, p = 0.7). There was no statistically significant association between psoriasis and non-functional dentition except in the fully adjusted model it became statistically significant (Prevalence Ratio 0.8, 95% CI 0.7–0.9, p = 0.04).
Conclusion
Psoriasis was associated with the lower prevalence of non-functional dentition after adjustment of potential confounders but was not associated with the higher prevalence of moderate/severe periodontitis.
Usefulness of the combined orthodontic rubber band and clip method for gastric endoscopic submucosal dissection
Authors: Li Dazhou , Zheng Linfu , Zhang Zewen , Chen Longping , Jiang Chuanshen , Wang Rong , Lin Jiahong , Lu Yiwen , Bai Yang , Wang Wen 
Published: October 2022

Abstract
Background and Aims

Effective traction is an important prerequisite for successful endoscopic submucosal dissection (ESD). The combined orthodontic rubber band (ORB) and clip method was effective in colorectal cancer ESD. To date, the method was not reported in gastric ESD. This study aimed to investigate its efficacy and safety for gastric neoplasms ESD.

Methods

We retrospectively analyzed data of 118 patients with gastric neoplasms treated by ESD from November 2020 to April 2022, 43 by ORB-ESD and 75 by the conventional ESD. The primary outcome measure was the ESD procedure time. Clinical data on efficacy and safety were also collected and analyzed. Propensity score matching (PSM) matched the patients in both groups.

Results

PSM successfully matched 31 pairs of patients. The ORB-ESD operation time was shorter (median [interquartile range], 35 [30–48] versus 49 [40–70] min, P < 0.001) and dissection speed was higher (median [interquartile range], 22.6 [14.4–29.3] versus 13.5 [9.6–17.9] mm2/min, P < 0.001) than in the conventional ESD. The groups were similar in muscular injury rate, frequency and time of use of thermal hemostatic forceps, postoperative adverse events, en bloc resection, and R0 resection rate (P > 0.05).

Conclusions

Compared to the conventional ESD, ORB-ESD significantly reduced the procedure time and increased the dissection speed, proving beneficial to gastric ESD.
Acamprosate reduces ethanol intake in the rat by a combined action of different drug components
Authors: Ademar Karin , Nilsson Mathilda , Domi Ana , Adermark Louise , Söderpalm Bo , Ericson Mia 
Published: October 2022

Abstract
Alcohol misuse accounts for a sizeable proportion of the global burden of disease, and Campral® (acamprosate; calcium-bis-(N-acetylhomotaurinate)) is widely used as relapse prevention therapy. The mechanism underlying its effect has in some studies been attributed to the calcium moiety and not to the N-acetylhomotaurine part of the compound. We recently suggested that the dopamine elevating effect of acamprosate is mediated both by N-acetylhomotaurine and calcium in a glycine receptor dependent manner. Here we aimed to explore, by means of in vivo microdialysis, if systemic administration of the sodium salt of N-acetylhomotaurine (sodium acamprosate; 200 mg/kg, i.p.) enhanced the effects of calcium chloride (CaCl2; 73.5 mg/kg, i.p.) on nucleus accumbens (nAc) dopamine and/or taurine levels in male Wistar rats. In addition, we investigated if N-acetylhomotaurine potentiates the ethanol-intake reducing effect of CaCl2 in a two-bottle choice voluntary ethanol consumption model followed by an alcohol deprivation effect paradigm. Systemic administration of regular acamprosate, sodium acamprosate or the combination of CaCl2 and sodium acamprosate significantly increased extracellular dopamine and taurine levels in the nAc. CaCl2 alone instantly increased dopamine but the effect did not sustain throughout the entire measured time period and taurine levels were not altered. Ethanol intake was significantly reduced by systemic administration of CaCl2, but the addition of sodium acamprosate prolonged the calcium-induced reduction of ethanol intake. Neither treatment suppressed the alcohol deprivation effect. The data presented suggest that CaCl2 and N-acetylhomotaurinate act in concert both regarding elevation of extracellular nAc dopamine levels and in reducing ethanol intake.
Impact of health literacy and social support on medication adherence in patients with hypertension: a cross-sectional community-based study
Authors: Guo Aizhen , Jin Hua , Mao Jianbo , Zhu Weihong , Zhou Ye , Ge Xuhua , Yu Dehua 
Published: October 2022

Abstract
Background
Previous studies have associated health literacy and social support with medication adherence in hypertension. However, limited evidence exists regarding the mechanisms between the factors and medication adherence.
Purpose
To explore the prevalence of medication adherence and its determinants in patients with hypertension in Shanghai.
Methods
A community-based cross-sectional study was conducted containing 1697 participants with hypertension. We collected the characteristics of sociodemographic and clinical, the profiles of health literature and social support, and medication adherence using questionnaires and examined interactions among the factors using a structural equation model.
Results
The participants contained 654 (38.54%) with low medication adherence, and 1043 (61.46%) with medium/high adherence. Social support influenced adherence directly (β = 0.165, P < 0.001) and indirectly through health literacy (β = 0.087, P < 0.001). Health literacy directly influenced adherence (β = 0.291, P < 0.001). Education indirectly affected adherence through social support (β = 0.048, P < 0.001) and health literature (β = 0.080, P < 0.001). Moreover, there was a sequential mediating effect of social support and health literature on the association between education and adherence (β = 0.025, P < 0.001). After controlling for age and marital status, similar results were also obtained, indicating a good model fit.
Conclusions
Medication adherence of hypertensive patients needs to improve. Health literacy and social support had direct and/or indirect effects on adherence, which should be more consider as the measures of improving adherence.
Metabolic profiles and fingerprints for the investigation of the influence of nitisinone on the metabolism of the yeast Saccharomyces cerevisiae
Authors: Kostina-Bednarz Marianna , Płonka Joanna , Nowak Paulina , Barchanska Hanna 
Published: October 2022

Abstract
Nitisinone (2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, NTBC) is considered a potentially effective drug for the treatment of various metabolic diseases associated with disorders of L-tyrosine metabolism however, side-effects impede its widespread use. This work aimed to broaden the knowledge of the influence of NTBC and its metabolites 2-amino-4-(trifluoromethyl)benzoic acid (ATFA), 2-nitro-4-(trifluoromethyl)benzoic acid (NTFA), and cyclohexane-1,3-dione (CHD) on the catabolism of L-tyrosine and other endogenous compounds in Saccharomyces cerevisiae. Based on a targeted analysis performed by LC-ESI-MS/MS, based on multiple reaction monitoring, it was found that the dissipation kinetics of the parent compound and its metabolites are compatible with a first-order reaction mechanism. The same mode of analysis was used to reveal that NTBC metabolites formed in the model organism cause a 15–59% decrease in L-tyrosine, L-tryptophan, and L-phenylalanine compared to the untreated model organism. The overall changes in the metabolism of yeast exposed to NTBC or its derivatives were evaluated by non-targeted analysis via LC-ESI-MS/MS in the ion trap scanning mode. Based on principal components analysis, a statistically significant similarity between metabolic responses of yeast treated with ATFA or NTFA was observed. These findings facilitate further studies investigating the influence of NTBC on the human body and the mechanism of its action.