bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PENERAPAN MODEL FLIPPED CLASSROOM COLLABORATIVE LEARNING TERHADAP KEMAMPUAN SCIENTIFIC REASONING DAN KEMAMPUAN SCIENTIFIC ARGUMENTATION
Authors: Magfirah Magfirah , Ahmar Dewi Satria , Sangkota Vivi Dia Aprianti 
Published: January 2022

Penelitian ini bertujuan untuk mengetahui: (a) gambaran kemampuan scientific reasoning dan scientific argumentation mahasiswa setelah mengikuti pembelajaran dengan model flipped classroom collaborative learning (b) Ada atau tidaknya pengaruh implementasi model flipped classroom collaborative learning terhadap kemampuan scientific reasoning dan scientific argumentation mahasiswa. Penelitian ini adalah quasy-experiment dengan desain two-group posttest only design. Populasi penelitian adalah mahasiswa Prodi Pendidikan Kimia Universitas Tadulako tahun akademik 2020/2021 semester genap. Sampel penelitian terdiri dari 21 mahasiswa di kelompok control dan 21 mahasiswa di kelompok eksperimen. Sampel ditentukan dengan teknik random sampling. Instrumen yang digunakan adalah The Lawson classroom test of scientific reasoning (LCTSR) dan Test of Scientific Argumentation . Teknik analisis data yang digunakan adalah statistik deskriptif dan statistik inferensial menggunakan independent sample t-test. Hasil penelitian menunjukkan kemampuan scientific reasoning dan kemampuan mahasiswa di kelompok eksperimen lebih tinggi daripada di kelompok control. Pada kelompok eksperimen rata-rata kemampuan scientific reasoning mahasiswa yaitu 66,45 dan pada kelompok kontrol 53,27. Pada kelompok eksperimen rata-rata kemampuan scientific argumentation yaitu 63,32 dan pada kelompok kontrol 52,82. Selain itu. Hasil uji independent sample t-test, nilai signifikansi terhadap data kemampuan scientific reasoning mahasiswa adalah 0,029 (<0,05) dan nilai signifikansi terhadap data kemampuan scientific argumentation mahasiswa adalah 0,042 (<0,05). Oleh karena itu disimpulkan bahwa terdapat pengaruh dari penerapan model flipped classroom-collaborative learning terhadap kemampuan scientific reasoning dan kemampuan scientific argumentation.
KARAKTER PEDULI LINGKUNGAN LAHAN BASAH: VALIDITAS MODEL PENDIDIKAN LINGKUNGAN
Authors: Sholahuddin Arif , Analita Rizki Nur , Fitriana Rezky , Sadiqin Ikhwan Khairu , Astuti Rani Widya 
Published: January 2022

Pengembangan karakter peduli lingkungan lahan basah pada siswa SD memerlukan model atau strategi yang tepat. Karakter peduli lingkungan tersebut meliputi kerja keras, menjaga kesehatan dan kebersihan, bertanggung jawab dan bijaksana terhadap lingkungan lahan basah. Penelitian ini mengembangkan model pendidikan karakter peduli lingkungan lahan basah (PKP-LLB). Penelitian pengembangan ini menggunakan model evaluasi formatif metode Tessmer yang terdiri dari atas evaluasi diri, prototyping, dan uji lapangan. Uji coba model PKP-LLB dilakukan di SDN Pasar Lama I Banjarmasin. Penelitian ini bertujuan untuk menghasilkan model PKP-LLB dan perangkat pendukungnya yang valid untuk meningkatkan karakter peduli lingkungan terhadap lingkungan lahan basah. Penelitian ini menemukan bahwa (1) desain PKP-LLB sangat valid berdasarkan telaah ahli, (2) perangkat pendukung utama model PKP-LLB sangat valid untuk digunakan dalam menerapkan model PKP-LLB untuk membekali pengetahuan. dan karakter peduli lingkungan lahan basah (3) siswa tidak mengalami kesulitan dalam membaca dan memahami materi penunjang pembelajaran. Berdasarkan hasil penelitian dapat disimpulkan bahwa model PKP-LLB ini valid, namun memerlukan uji coba dan evaluasi lebih lanjut untuk mencapai kepraktisan dan keefektifannya.
Initial Cenozoic Exhumation of the Northern Chinese Tian Shan Deduced from Apatite (U-Th)/He Thermochronological Data
Authors: Yu Jingxing , Zheng Dewen , Zhang Huiping , Wang Yizhou , Hao Yuqi , Li Chaopeng 
Published: January 2022

Abstract
The present topography of Tian Shan is related to the India-Asia collision, whereas the mechanisms for the topographic growth of Tian Shan remain at the center of debate partly due to the poorly constrained onset timing of the Cenozoic tectonic deformation. Our new apatite (U-Th)/He (AHe) data in the northern Chinese Tian Shan suggest that rapid cooling commenced at 20.2±4.9 Ma along the northern margin, which is consistent with published fission-track data from the same area and confirms that the youngest component of fission-track has been totally annealed. Moreover, AHe data from the interior mountain suggest that enhanced cooling began at 28.0±2.3 Ma, which is slightly older than that from the northern edge of the mountain. Although thermochronological data suggest that both the interior and northern margin of the northern Chinese Tian Shan have undergone rapid cooling since the late Oligocene-early Miocene, well preservation of relict low-relief surfaces along the northern rim of the northern Chinese Tian Shan and published thermochronological data indicate that the northern Chinese Tian Shan may have experienced differential exhumation in the Cenozoic. Combining the thermochronological and geomorphological evidence, we propose a progressive northward growth model for the northern Chinese Tian Shan. During the late Oligocene and early Miocene, compressive deformation derived from the India-Asia collision have arrived at the northern Tian Shan to reactivate both the interior mountain and its northern margin, while intense exhumation was concentrated in the interior mountain range. Then, deformation extended northward into the foreland basin that may be initiated in the middle-late Miocene.
Iron Sulfide Solubility Measurement and Modeling Over Wide Ranges of Temperatures, Ionic Strength, and pH
Authors: Wang Xin , Dai Zhaoyi , Ko Saebom , Deng Guannan , Zhao Yue , Dai Chong , Li Wei , Paudyal Samridhdi , Yao Xuanzhu , Kan Amy T. , Tomson Mason 
Published: January 2022

Summary
Iron sulfides constitute a diverse group of solid phases and aqueous complexes, many of which are critical in both natural and industrial processes, such as marine sedimentation, oil and gas productions, metallic equipment corrosion by hydrogen sulfide, and water treatment, to mention a few. As the fundamental basis of related research on iron sulfides, an accurate thermodynamic model for iron sulfide solubility prediction under wide ranges of conditions (e.g., water compositions, temperature, pressure, and pH) is required. In this study, a plug flow reactor was built to measure iron sulfide solubility at various temperatures (25–90°C), pH (5.9–6.9), and ionic strength (0.150–4.27 mol/kg). Using the mackinawite solubility data measured in this study and in literature, a new Pitzer theory-based thermodynamic model with the explicit presence of ion complexes was developed. In this model, a neutral aqueous ion complex, FeSaq, was included explicitly. The mackinawite solubility product constant was fitted with a temperature-dependent equation from 23 to 125°C: pKsp,m=−94.97+4,444TK+14.64×ln(TK), with TK as temperature in Kelvin. This model can accurately predict the mackinawite solubility with standard error of estimate (SEE) of the mean SI = ±0.015 SI units, under wide ranges of temperature (23–125°C), pH (3.16–9.66), ionic strength (0–5 mol/kg water), and Fe(II) to S(-II) molar ratio (from 1:1,000 to 10,000:1). The Gibbs free energy and enthalpy of formation for mackinawite were also derived. This new model could help improve FeS scaling and corrosion control in complicated industrial systems, as well as the sulfide-related heavy metal transport in natural aqueous systems.
Optimization of Engine Parameters using NSGA II for the Comprehensive Reduction of Emissions from VCR Engine Fuelled with ROME Biodiesel
Authors: Saravanamuthu Murugapoopathi , Thulasiram Ramachandran , Ramasamy Dharmalingam , Sundaramoorthy Surendarnath 
Published: January 2022

Abstract
Diesel engines are most widely used as power plant for many applications, like automotive, agricultural purposes, portable machines and remote location power generation, because of their higher torque, power output, energy content per unit mass and cost of fuel. Because of the higher compression ratios, the diesel engines are able to produce greater cylinder pressures resulting in higher temperatures and thermal efficiency. On other hand, the diesel engines produce COx, NOx, Soot and sulphur emissions which are harmful and pollute the environment leads to acid rain, global warming and variety of human diseases. Also, the Present emission regulations are framed such a way to ensure the environmental sustainability in addition to the economic and social importance. These constraints make the researchers to find an alternate fuel for replacing the diesel fuel on the existing diesel engines for the reduction of environmental pollutions. Biodiesel is found to be a very good alternative fuel obtained from natural resources and having good energy with least possible emissions. Rubber seed methyl ester (ROME) is one kind of the biofuel can be used in the existing diesel without any engine modifications. The ROME is produced using trans esterification process and the biodiesel blends are prepared in the sequence of B20, B40, B60 and B80. The ROME is tested on the Variable Compression Ratio (VCR) engine to test the emission characteristic in line with the performance characteristics. To reduce the emissions, the prediction models are developed for CO and NOx using the Response Surface Methodology (RSM). The models are verified through the ANOVA and p-test for their adequacy to create the hypothesis of the experimentation. The NSGA II evolutionary multi-objective optimization is used to optimize the engine parameters to minimise the pollutions from the ROME fuelled engine. Finally, the optimized parameters are verified though the experimentation to verify the least possible emissions from the engine.
Effectiveness of Intra-Articular Injection of Platelet-Rich Plasma (PRP) In Isolated Patellofemoral Arthritis
Authors: El-Desouky Ihab Ibraheem 
Published: January 2022

Abstract

Background: Adults commonly develop isolated patellofemoral arthritis (PFA). It has been suggested that platelet-rich plasma (PRP) may be beneficial in the conservative treatment of tibiofemoral knee osteoarthritis (OA). The purpose of this study is to compare patient complaints prior to and following PRP injection for PFA during conservative treatment.Materials and methods: This study included eighteen female patients with unilateral PFA between the ages of 25 and 40 years. They received a single dose of PRP injections after failing to respond to conservative treatment. The outcome measures, which included VAS and Kujala scores, were compared to a matched group of eighteen patients managed conservatively but successfully. Both groups received the same physiotherapy regimen, and all patients were followed for one year until the final assessment.Results: At the final follow-up, the PRP group's VAS scale was significantly improved compared to their pre-injection status, with a p-value of < 0.001. However, no statistically significant difference was observed between the PRP and the non-PRP groups that improved with conservative treatment (p>0.9). Comparable results were obtained when the two groups' Kujala scores were compared.Conclusion: Patients with isolated patellofemoral arthritis who do not respond to conservative treatment may benefit from a single PRP injection, which may postpone or eliminate the need for surgical treatment.
Hepatic Fibrosis: A Manifestation of the Evolution of Liver Disease in Patients with Ataxia-Telangiectasia
Authors: Barreto Talita Lemos Neves , Filho Roberto José de Carvalho , Shigueoka David Carlos , Fonseca Fernando Luiz Affonso , Ferreira Ariel Cordeiro , Kochi Cristiane , Aranda Carolina Sanchez , Sarni Roseli Oselka Saccardo 
Published: January 2022

Abstract
Background: Ataxia-telangiectasia (A-T) is a DNA repair disorder characterized by changes in several organs and systems. Advances in clinical protocols have resulted in increased survival of A-T patients, however disease progression is evident, mainly through metabolic and liver changes. We aimed to identify the frequency of significant hepatic fibrosis in A-T patients and to verify association with metabolic alterations and degree of ataxia. Results: Dyslipidemia was observed in 16/25 (64%), diabetes in 4/22 (18%), insulin resistance in 5/17 (29%), hepatic steatosis in 13/20 (65%) and suggestive of significant hepatic fibrosis in 5/25 (20%). Patients in the group with significant hepatic fibrosis were older (p<0.001), had lower platelet values (p=0.027), albumin (p=0.019), HDL-c (p=0.013) and Matsuda index (p=0.044); and high values of LDL-c (p=0.049), AST (p=0.001), alanine aminotransferase (p=0.002), gamma-glutamyl transferase (p=0.001), ferritin (p=0.001), 120-minutes glycemia by OGTT (p=0.049), HOMA-AD (p=0.016) and degree of ataxia (p=0.009). Conclusions: A suggestive diagnosis of significant hepatic fibrosis was observed in 20% of A-T patients which was associated with changes in liver enzymes, ferritin, increased HOMA-AD and with severity of ataxia compared to patients without hepatic fibrosis.
Out-of-date datasets hamper conservation of species close to extinction
Authors: Abeli Thomas , Sharrock Suzanne , Rocchetti Giulia Albani 
Published: January 2022

Abstract
International databases and data aggregators on species conservation status are powerful tools supporting the efforts of conservation biologists and practitioners in reducing the loss of biodiversity. However, out-of-date information and poor interoperability of databases can hamper conservation of highly threatened species or in extreme cases can result in their removal from conservation frameworks. Lack of common standards for database updates, slow update timing and incongruencies among datasets result in confusing information that prevent proper conservation prioritisation and actions. A simple survey to update and solve incongruencies between the BGCI PlantSearch Database, the IUCN Red List and other datasets resulted in a change of status of sixteen plant species, including the “rehabilitation” of fourteen species thought to be extinct.
3D Reconstruction From Structured-Light Profilometry With Dual-Path Hybrid Network
Authors: Wang Lei , Lu Dunqiang , Qiu Ruowen , Tao Jiaqing 
Published: January 2022

Abstract
With the rapid development of high-speed image sensors and optical imaging technology, these have effectively promoted the improvement of non-contact 3D shape measurement. Among them, striped structured-light technology has been widely used because of its high measurement accuracy. Compared with classical methods such as Fourier transform profilometry, many deep neural networks are utilized to restore 3D shape from single shot structured-light. In actual engineering deployments, the number of learnable parameters of convolution neural network (CNN) is huge, especially for high-resolution structured-light patterns. To this end, we proposed a dual-path hybrid network based on UNet, which eliminates the deepest convolution layers to reduce the number of learnable parameters, and a swin transformer path is additionally built on the decoder to improve the global perception of this network. The experimental results show that the learnable parameters of the model are reduced by 60% compared with the UNet, and the measurement accuracy is not degraded at the same time. The proposed dual-path hybrid network provides an effective solution for structured-light 3D reconstruction and its practice in engineering.
ETC-1002 Attenuates Porphyromonas Gingivalis Lipopolysaccharide-Induced Inflammation in RAW264.7 Cells via the AMPK/NF-κB Pathway and Exerts Ameliorative Effects in Experimental Periodontitis in Mice
Authors: Li Hong-yan , Zhang Peipei , Lin Hongbing , Gao Huan , Yin Jianyuan 
Published: January 2022

Abstract
Periodontitis is a chronic inflammatory disease characterized by periodontal tissue destruction and tooth loss. Clinically, the failure of periodontal therapy stems largely from an inability to control the inflammatory response. Resolution of inflammation is an active, energy-requiring repair process, not merely a passive termination of inflammation. AMP-activated protein kinase (AMPK), a key energy sensor, has been shown to negatively regulate inflammatory signaling pathways. ETC-1002 is an activator of AMPK. This study aimed to investigate the anti-inflammatory effects of ETC-1002 through modulating AMPK in periodontitis. Results suggested that ETC-1002 exerts anti-inflammatory effects in Pg-LPS-treated RAW264.7 cells via the AMPK/NF-κB pathway in vitro, and inhibits the progress of experimental periodontitis in mice in an AMPK signaling-dependent manner in vivo. These results provide evidence for the beneficial effects of ETC-1002 in the treatment of periodontitis.
Ultrasensitive Detection of COVID-19 Virus N Protein Based on p-Toluenesulfonyl Modified Fluorescent Microspheres Immunoassay
Authors: Mao Mao , Wu Feng , Shi XueYing , Huang YuLan , Ma Lan 
Published: January 2022

Abstract

The pandemic of new coronary pneumonia caused by the COVID-19 virus continues to ravage the world. Large-scale population testing is the key to controlling infection and related mortality worldwide. Lateral flow immunochromatographic assay (LFIA) is fast, inexpensive, simple to operate, and easy to carry, very suitable for detection sites. This study developed a COVID-19 N protein detect strip based on p-toluenesulfonyl modified rare earth fluorescent microspheres. The p-toluenesulfonyl-activated nanomaterials provide reactive sulfonyl esters to covalently attach antibodies or other ligands containing primary amino or sulfhydryl groups to the nanomaterial surface. Antibodies are immobilized on these nanomaterials through the Fc region, which ensures optimal orientation of the antibody, thereby increasing the capture rate of the target analyte. The use of buffers with high ionic strength can promote hydrophobic binding, in addition, higher pH could promote the reactivity of the tosyl group. The detection limit of the prepared COVID-19 N protein strips can reach 0.01ng/mL so it has great application potential in large-scale population screening.
Adipocyte-derived CCDC3 Promotes Tumorigenesis in Epithelial Ovarian Cancer Through the Wnt/ß-catenin Signalling Pathway
Authors: Wang Fen , Jin Feng , Peng Shanshan , Li Chen , Wang Li , Wang Shubin 
Published: January 2022

Abstract
Background: Epithelial ovarian cancer (EOC) is a highly aggressive disease whose unique metastatic site is the omentum. Coiled-coil domain containing 3 (CCDC3) is an adipocyte-derived secreted protein that is specifically elevated in omental adipose tissue. However, its function is still unknown.Results: Overexpression of CCDC3 was associated with poor prognosis of EOC. CCDC3 interacted with multiple key signalling pathways, including the Wnt/β-catenin pathway. EOC cellular proliferation, migration, and invasion were promoted in vitro when co-cultured with conditioned medium containing CCDC3, and this tumour-promoting effect was induced by activating the Wnt/β-catenin pathway. Furthermore, the epithelial-mesenchymal transition of EOC cells was reversed after CCDC3 silencing.Conclusions: Our results support that CCDC3 promotes EOC tumorigenesis through the Wnt/β-catenin pathway and that CCDC3 may serve as a novel prognostic biomarker and therapeutic target for metastatic EOC.
Mechanical ventilation and histological fibrosis in patients with acute respiratory distress syndrome undergoing open lung biopsy
Authors: Li Hsin-Hsien , Wang Chih-Wei , Chang Chih-Hao , Huang Chung-Chi , Hsu Han-Shui , Chiu Li-Chung 
Published: January 2022

Abstract
Background: Mechanical ventilation is the most important support treatment for acute respiratory distress syndrome (ARDS); however, it brings with it the risk of ventilator-induced lung injury, which can lead to pulmonary fibrosis and prolonged mechanical ventilation. Our objective in this study was to examine the correlation between ventilator settings and histological fibrosis in ARDS patients. We also examined the impact of histological fibrosis on clinical outcomes and mortality.
Methods: We performed a retrospective analysis of patients with ARDS who received open lung biopsy in a tertiary care referral center in Taiwan between March 2006 and December 2019. Mechanical ventilator settings were recorded at the time of ARDS diagnosis and on the day of biopsy.
Results: A total of 68 ARDS patients who had received open lung biopsy with diffuse alveolar damage (DAD; the hallmark pathology of ARDS) were analyzed and stratified into non-fibrosis (n = 56) and fibrosis groups (n = 12). Mechanical power and airway pressures at the time of ARDS diagnosis and airway pressures on the day of biopsy were significantly higher in the fibrosis group than in the non-fibrosis group, and lung compliance on the day of biopsy was significantly lower. The duration of ventilator usage and time spent in the intensive care unit and hospital stay were all significantly higher in the fibrosis group. Hospital mortality was higher in the fibrosis than in the non-fibrosis group (67% vs. 57%, p = 0.748). In the fibrosis group, patients with AE-IPF (n = 5) received higher ventilator load and faced higher hospital mortality than DAD with fibrotic phase (n = 7) (80% vs. 57%, p = 0.242). A multivariable logistic regression model demonstrated that mechanical power at ARDS diagnosis and ARDS duration before biopsy were independently associated with histological fibrosis at open lung biopsy (odds ratio 1.493 [95% CI 1.014–2.200], p = 0.042; odds ratio 1.160 [95% CI 1.052–1.278], p = 0.003, respectively).
Conclusions: Our findings indicate that prompt action aimed at staving off injurious mechanical stretching of lung parenchyma and subsequent progression to fibrosis may have a positive effect on clinical outcomes.
Keywords: Mechanical ventilation, Acute respiratory distress syndrome, Open lung biopsy, Histology, Diffuse alveolar damage, Pulmonary fibrosis, Idiopathic pulmonary fibrosis, Outcomes
FLASH irradiator at the Radiological Research Accelerator Facility.
Authors: Garty Guy , Obaid Razib , Deoli Naresh , Royba Ekaterina , harken Andrew D. , Brenner David J. 
Published: January 2022

Abstract
The Radiological Research Accelerator Facility has modified a decommissioned Varian Clinac to deliver FLASH dose rates: Operating in 9 MeV electron mode (FLASH mode), samples can be irradiated inside the Clinac head at average dose rates of up to 600 Gy/sec (3 Gy per 0.5 µsec pulse, 180 pulses per sec). In this mode multiple pulses are required for most irradiations. By modulating pulse repetition rate, dose rates below 1 Gy/min can be achieved, allowing comparison of FLASH and conventional irradiations with the same beam. Operating in 6 MV photon mode, with the conversion target removed (superFLASH mode), samples are irradiated at instantaneous dose rates of up to 1 GGy/sec (0.2-150 Gy per pulse, 360 pulses per sec) and most irradiations can be performed with a single very high dose rate pulse. In both modes we have seen the expected inverse relation between dose rate and irradiated area, with the highest dose rates obtained for beams with a FWHM of about 2 cm and ±10% uniformity over 1 cm diameter. As an example of operation of the FLASH irradiator, we present dose rate dependence of dicentric chromosome yields.
Optimising data visualisation in the process control and IIoT environments
Authors: Maharaj Robin , Balyan Vipin , Khan Mohammed Tariq 
Published: January 2022

Abstract
In the present context of the 4th Industrial revolution, there is a growing need to get data from different data sources in a standard data format. This paper presents a solution to achieve this convergence in using IoT technology, extracting available data, and making it available to high-level systems in a standard, low latency framework. This paper presents different protocols like OPC UA, Message Queuing Telemetry Transport (MQTT), and Constrained Application Protocol(COAP) to achieve this data transportation/acquisition. It also presents an emerging Low Power Wide Area Network (LPWAN) technology, LoRa WAN, to augment the data of the process control system, explicitly extending the range of sensors to wireless data points.