bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of dexmedetomidine and remifentanil on reducing coughing during emergence from anesthesia with tracheal intubation: A meta-analysis
Authors: Fan Xing , Cai Hai , Pan Bingbing , Xie Yubo 
Published: September 2022

Background: Dexmedetomidine and remifentanil are well known to suppress airway reflex during emergence from anesthesia, but which one is more effective is unclear. We conducted a meta-analysis to compare the effect of dexmedetomidine and remifentanil on reducing the occurrence of coughing.Methods: We systematically searched PubMed, Embase, and Cochrane Library for randomized controlled trials (published between 1 January 1950, and 30 December 2021; no language restrictions) comparing dexmedetomidine infusion with remifentanil infusion. The primary endpoint was the incidence of moderate to severe coughing during the recovery period. The secondary endpoints were the time of recovery and extubation, and residual sedation. We assessed pooled data by using a random-effects model.Results: Eight studies with 502 participants were included. The meta-analysis showed no statistically difference between dexmedetomidine and remifentanil in the occurrence of moderate to severe coughing during emergence from anesthesia (OR 1.45,95%CI 0.62–3.38), the extubation time (MD 0.93 min, 95%CI -0.28–2.14), and the residual sedation (OR 2.52, 95%CI 0.92–6.91). Compared with dexmedetomidine, the average recovery time of remifentanil was shorter (MD 3.88 min, 95%CI 1.01–6.75).Conclusion: Dexmedetomidine and remifentanil infusion had no difference in the occurrence of moderate to severe coughing during emergence from anesthesia.Clinical Trial Registration:https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42021239710
Time limit and V̇O2 kinetics at maximal aerobic velocity: Continuous vs. intermittent swimming trials
Authors: Almeida Tiago A. F. , Massini Danilo A. , Silva Júnior Osvaldo T. , Venditti Júnior Rubens , Espada Mário A. C. , Macedo Anderson G. , Reis Joana F. , Alves Francisco B. , Pessôa Filho Dalton M. 
Published: September 2022

The time sustained during exercise with oxygen uptake (V̇O2) reaching maximal rates (V̇O2peak) or near peak responses (i.e., above second ventilatory threshold [t@VT2) or 90% V̇O2peak (t@90%V̇O2peak)] is recognized as the training pace required to enhance aerobic power and exercise tolerance in the severe domain (time-limit, tLim). This study compared physiological and performance indexes during continuous and intermittent trials at maximal aerobic velocity (MAV) to analyze each exercise schedule, supporting their roles in conditioning planning. Twenty-two well-trained swimmers completed a discontinuous incremental step-test for V̇O2peak, VT2, and MAV assessments. Two other tests were performed in randomized order, to compare continuous (CT) vs. intermittent trials (IT100) at MAV until exhaustion, to determine peak oxygen uptake (Peak-V̇O2) and V̇O2 kinetics (V̇O2K). Distance and time variables were registered to determine the tLim, t@VT2, and t@90%V̇O2peak tests. Blood lactate concentration ([La−]) was analyzed, and rate of perceived exertion (RPE) was recorded. The tests were conducted using a breath-by-breath apparatus connected to a snorkel for pulmonary gas sampling, with pacing controlled by an underwater visual pacer. V̇O2peak (55.2 ± 5.6 ml·kg·min−1) was only reached in CT (100.7 ± 3.1 %V̇O2peak). In addition, high V̇O2 values were reached at IT100 (96.4 ± 4.2 %V̇O2peak). V̇O2peak was highly correlated with Peak-V̇O2 during CT (r = 0.95, p &lt; 0.01) and IT100 (r = 0.91, p &lt; 0.01). Compared with CT, the IT100 presented significantly higher values for tLim (1,013.6 ± 496.6 vs. 256.2 ± 60.3 s), distance (1,277.3 ± 638.1 vs. 315.9 ± 63.3 m), t@VT2 (448.1 ± 211.1 vs. 144.1 ± 78.8 s), and t@90%V̇O2peak (321.9 ± 208.7 vs. 127.5 ± 77.1 s). V̇O2K time constants (IT100: 25.9 ± 9.4 vs. CT: 26.5 ± 7.5 s) were correlated between tests (r = 0.76, p &lt; 0.01). Between CT and IT100, tLim were not related, and RPE (8.9 ± 0.9 vs. 9.4 ± 0.8) and [La−] (7.8 ± 2.7 vs. 7.8 ± 2.8 mmol·l−1) did not differ between tests. MAV is suitable for planning swimming intensities requiring V̇O2peak rates, whatever the exercise schedule (continuous or intermittent). Therefore, the results suggest IT100 as a preferable training schedule rather than the CT for aerobic capacity training since IT100 presented a significantly higher tLim, t@VT2, and t@90%V̇O2peak (∼757, ∼304, and ∼194 s more, respectively), without differing regards to [La−] and RPE. The V̇O2K seemed not to influence tLim and times spent near V̇O2peak in both workout modes.
Pedestrians’ psychological preferences for urban street lighting with different color temperatures
Authors: Hao Xinyi , Zhang Xin , Du Jiangtao , Wang Meichen , Zhang Yalan 
Published: September 2022

White LEDs, which have been widely used in the urban street lighting, are increasingly applied to replace traditional HPS lamps with a lower CCT (correlated color temperature). Generally, studies on the CCT of street lighting focus on providing safe functional lighting for vehicle drivers. However, it is still unknown how the street light color can affect pedestrians’ perception and preferences with respect to lighting levels and ambient temperature.In this study, a wide range of CCTs (1,600–5,400 K) was measured for urban street lighting in Beijing, China, for example. And the transition from traditional HPS lamps to LEDs lacks a reference street lighting standard for CCT. The study aims to conduct a cross-sensory test to evaluate urban street lighting with multiple combinations of CCT values and illuminance levels according to pedestrians’ visual perception and psychological preferences.A total of 18 night street lighting scenes with six CCT values and three illuminance levels were first selected in Beijing city, and then HDR videos of these scenes were taken from the view of pedestrians to conduct psychological experiments in an indoor environment with three ambient temperatures. A total of 77 university students (24 males) were invited to assess videos of the 18 lighting scenes in terms of seven factors, such as lighting brightness, color temperature sensation, light color preference, sense of safety, recognition, comfort, and overall preference. Several key findings were achieved as follows. (1) The CCT of urban street lighting can have significant effects on the visual psychological perceptions of participants. (2) There was a significant interaction between CCT, illuminance, and ambient temperature on the visual psychological performances of participants. (3) The higher ambient temperature will deliver the higher level of overall preference for the street lighting with medium and high CCT, and the perception of warmer light color. (4) There was a strong correlation found between participants’ light color preference, comfort, and overall preferences.
Association between acrylamide exposure and the odds of developmental disabilities in children: A cross-sectional study
Authors: Meng Fanchao , Qi Yanjie , Wu Yuanzhen , He Fan 
Published: September 2022

BackgroundThe association between acrylamide exposure and the odds of developmental disabilities (DDs) is unclear. We conducted this analysis to explore whether acrylamide exposure is related to DDs.MethodsWe analyzed a sample of 1,140 children aged 6–17 years old from the US National Health and Nutrition Examination Survey 2013–2014 to 2015–2016. DDs were determined by reports of parents. Acrylamide exposure was evaluated by the hemoglobin adducts of acrylamide (HbAA) and its major metabolite glycidamide (HbGA). We investigated the association using binomial logistic regression analysis by taking HbAA and HbGA as continuous or quartile variables. Restricted cubic splines (RCS) were used to explore the non-linear relationship between HbAA or HbGA and the odds of DDs. Interaction analysis and propensity score matching (PSM) were used to validate the results.ResultsA total of 134 participants were reported to have DDs. The median level of HbAA and HbGA was 41.6 and 40.5 pmol/g Hb, respectively. HbAA and HbGA were not associated with the odds of DDs when taken as continuous variables. When divided into quartiles, there was no evidence for a linear trend for HbAA and HbGA. RCS showed that there was a J-shaped association between HbGA and the odds of DDs (P for non-linearity, 0.023). The results were consistent in interaction analysis by age, gender, and race, and after PSM.ConclusionHbGA level was associated with the odds of DDs in a J-shaped manner among children. Further investigation is warranted to determine the causality and underlying mechanisms.
Discovery top-down proteomics in symbiotic soybean root nodules
Authors: Zhou Mowei , Fulcher James M. , Zemaitis Kevin J. , Degnan David J. , Liao Yen-Chen , Veličković Marija , Veličković Dušan , Bramer Lisa M. , Kew William R , Stacey Gary , Paša-Tolić Ljiljana 
Published: September 2022

Proteomic methods have been widely used to study proteins in complex biological samples to understand biological molecular mechanisms. Most well-established methods (known as bottom-up proteomics, BUP) employ an enzymatic digestion step to cleave intact proteins into smaller peptides for liquid chromatography (LC) mass spectrometry (MS) detection. In contrast, top-down proteomics (TDP) directly characterizes intact proteins including all possible post-translational modifications (PTMs), thus offering unique insights into proteoform biology where combinations of individual PTMs may play important roles. We performed TDP on soybean root nodules infected by the symbiotic Bradyrhizobium japonicum in both the wildtype bacterium and a nifH- mutant, which lacks the ability to fix nitrogen in the soybean root nodule. TDP captured 1648 proteoforms derived from 313 bacterial genes and 178 soybean genes. Leghemoglobin, the most abundant protein in the sample, existed in many truncated proteoforms. Interestingly, these truncated proteoforms were considerably more abundant in the wildtype relative to the nifH- mutant, implicating protease activity as an important factor in nitrogen fixation. Proteoforms with various PTMs and combinations thereof were identified using an unrestricted open modification search. This included less common PTMs such as myristoylation, palmitoylation, cyanylation, and sulfation. In parallel, we collected high resolution MS imaging (MSI) data of intact proteins and biopolymers (&lt;20 kDa due to current technical limitations) from sections of the soybean root nodules using matrix-assisted laser desorption/ionization (MALDI) coupled to high resolution Orbitrap. Several detected proteoforms exhibited unique spatial distributions inside the infection zone and cortex, suggesting functional compartmentalization in these regions. A subset of peaks from the MALDI-MSI were assigned to proteoforms detected in TDP LCMS data based on matching accurate masses. Many of the proteins detected in both LCMS and MALDI-MSI are currently uncharacterized in UniProt: the PTM and spatial information presented here will be valuable in understanding their biological functions. Taken together, our study demonstrates how untargeted TDP approach can provide unique insights into plant proteoform biology. On-going technology developments are expected to further improve TDP coverage for more comprehensive high-throughput analysis of proteoforms.
Bistable carbon-vacancy defects in h-BN
Authors: Li Song , Gali Adam 
Published: September 2022

Single-photon emitters in hexagonal boron nitride have been extensively studied recently. Although unambiguous identification of the emitters is still under intense research, carbon-related defects are believed to play a vital role for the emitter producing zero-phonon lines in the range of 1.6–2.2 eV. In this study, we systematically investigate two configurations of carbon-vacancy defects, VNCB and CNVB, by means of density functional theory calculations. We calculated the reaction barrier energies from one defect to the other to determine relative stability. We find that the barrier energies are charge dependent, and CNVB could easily transform to VNCB in neutral- and positive-charge states while it is stable when negatively charged. Formation energy calculations show that the VNCB is the dominant defect over CNVB. However, neither VNCB nor CNVB has suitable fluorescence spectra that could reproduce the observed ones. Our results indicate that the origin of the 1.6-to-2.2-eV emitters should be other carbon-related configurations.
Precision public-health intervention for care coordination: a real-world study
Authors: Andrade Andre Q , Calabretto Jean-Pierre , Pratt Nicole L , Kalisch-Ellett Lisa M , Le Blanc Vanessa T , Roughead Elizabeth E 
Published: September 2022

BackgroundHealth emergencies disproportionally affect vulnerable populations. Digital tools can help primary care providers find, and reach, the right patients.AimTo evaluate whether digital interventions delivered directly to GPs’ clinical software were more effective at promoting primary care appointments during the COVID-19 pandemic than interventions delivered by post.Design and settingReal-world, non-randomised, interventional study involving GP practices in all Australian states.MethodIntervention material was developed to promote care coordination for vulnerable older veterans during the COVID-19 pandemic, and sent to GPs either digitally to the clinical practice software system or in the post. The intervention material included patient-specific information sent to GPs to support care coordination, and education material sent via post to veterans identified in the administrative claims database. To evaluate the impact of intervention delivery modalities on outcomes, the time to first appointment with the primary GP was measured; a Cox proportional hazards model was used, adjusting for differences and accounting for pre-intervention appointment numbers.ResultsThe intervention took place in April 2020, during the first weeks of COVID-19 social distancing restrictions in Australia. GPs received digital messaging for 51 052 veterans and postal messaging for 26 859 veterans. The digital group was associated with earlier appointments (adjusted hazard ratio 1.38 [1.34 to 1.41]).ConclusionData-driven digital solutions can promote care coordination at scale during national emergencies, opening up new perspectives for precision public-health initiatives.
Continuity of care in diverse ethnic groups: a general practice record study in England
Authors: Stafford Mai , Bécares Laia , Hayanga Brenda , Ashworth Mark , Fisher Rebecca 
Published: September 2022

BackgroundGPs and patients value continuity of care. Ethnic differences in continuity could contribute to inequalities in experience and outcomes.AimTo describe relational continuity of care in general practice by ethnicity and long-term conditions.Design and settingIn total, 381 474 patients in England were included from a random sample from the Clinical Practice Research Datalink (January 2016 to December 2019).MethodFace-to-face, telephone, and online consultations with a GP were included. Continuity, measured by the Usual Provider of Care and Bice–Boxerman indices, was calculated for patients with ≥3 consultations. Ethnicity was taken from the GP record or linked Hospital Episode Statistics data, and long-term conditions were counted at baseline. Multilevel regression models were used to describe continuity by ethnicity sequentially adjusted for: a) the number of consultations, follow-up time, age, sex, and practice-level random intercept; b) socioeconomic deprivation in the patient’s residential area; and c) long-term conditions.ResultsOn full adjustment, 5 of 10 ethnic minority groups (Bangladeshi, Pakistani, Black African, Black Caribbean, and any other Black background) had lower continuity of care compared with White patients. Continuity was lower for patients in more deprived areas and younger patients but this did not account for ethnic differences in continuity. Differences by ethnicity were also seen in patients with ≥2 long-term conditions.ConclusionEthnic minority identity and socioeconomic deprivation have additive associations with lower continuity of care. Structural factors affecting demand for, and supply of, GPs should be assessed for their contribution to ethnic inequalities in relational continuity and other care quality domains.
ANALISIS KEPERCAYAAN DAN KUALITAS PELAYANAN TERHADAP KEPUASAN PELANGGAN
Authors: Caniago Aspizain 
Published: October 2022

<p align="justify">Tujuan dari penelitian ini adalah untuk mengetahui adanya pengaruh Kepercayaan terhadap Kepuasan Pelanggan<span>,</span><span lang="IN"> pengaruh Kualitas </span><span>P</span><span lang="IN">elayanan terhadap Kepuasan Pelanggan, </span><span>p</span><span lang="IN">engaruh Kepercayaan dan Kualitas </span><span>P</span><span lang="IN">elayanan secara simultan terhadap Kepuasan Pelanggan </span><span>Bimbel SCI Jakarta</span><span lang="IN">. Penelitian ini dilakukan dari </span><span>Januari - Juni</span><span lang="IN"> 202</span><span>2</span><span lang="IN">, dengan jenis penelitian eksplanatori yang juga bersifat korelasional, dengan metode survey menggunakan kuesioner dimana yang menjadi responden adalah </span><span>siswa Bimbel SCI Jakarta</span><span lang="IN">. populasi dari penelitian ini adalah sebanyak </span><span>50</span><span>Siswa</span><span lang="IN">, kemudian melalui rumus Slovin ditetapkan sampel sebesar </span><span>44</span><span lang="IN"> responden</span><span>. </span><span lang="IN">Analisis data dilakukan secara deskriptif dan uji hipotesis, dimana hasil penelitian secara deskriptif </span><span lang="IN">variabel Kepercayaan</span><span>,</span><span lang="IN"> Kualitas </span><span>P</span><span lang="IN">elayanan maupun Kepuasan Pelanggan berada dalam kategori mendekati setuju, artinya bahwa </span><span>siswa </span><span> </span><span>Bimbel SCI Jakarta</span><span lang="IN"> setuju bahwa </span><span>Bimbel SCI Jakarta</span><span lang="IN"> memenuhi indikator-indikator masing-masing variabel. <span>Pada Uji Hipotesis melalui hasil SPSS terhadap tabel Anova dimana </span></span><span>h</span><span lang="IN">ipotesis (</span><span>1</span><span lang="IN">) Kepercayaan berpengaruh terhadap Kepuasan Pelanggan</span><span>, </span><span lang="IN">hipotesis (</span><span>2</span><span lang="IN">) Kualitas pelayanan</span><span lang="IN"> berpengaruh terhadap Kepuasan Pelanggan</span><span>,</span><span lang="IN"> Kemudian pada hipotesis (3) Kepercayaan dan Kualitas </span><span>P</span><span lang="IN">elayanan secara simultan berpengaruh terhadap Kepuasan Pelanggan.</span></p><p class="Style3"><strong>Kata Kunci: </strong>Kepercayaan, Kualitas Pelayanan, Kepuasan Pelanggan</p>
PROBLEMS AND PROSPECTS OF IMPORT SUBSTITUTION OF SOFTWARE IN THE RUSSIAN FEDERATION
Authors: Громов Юрий Юрьевич , Пушкин Павел Юрьевич , Карасев Павел Игоревич , Иванов Александр Григорьевич 
Published: October 2022

В работе рассматривается понятие свободного программного обеспечения, его характерные черты, особенности, а также преимущества и недостатки. Описываются причины заинтересованности государственных органов в осуществлении политики, направленной на развитие свободного программного обеспечения вместо устоявшихся проприетарных средств. В хронологическом порядке приводятся распоряжения и приказы государственных органов, которые задают требования по реализации мероприятий, направленных на осуществление политики импортозамещения программного обеспечения в Российской Федерации, а также их результаты. Проводится статистический анализ использования некоторых программных продуктов, относящихся к свободному программному обеспечению. На основании данного исследования выдвигаются предположения о причинах установленной заинтересованности конечных пользователей в применении свободного программного обеспечения для ежедневных нужд. В завершении делается заключение о перспективах внедрения свободного программного обеспечения вместо имеющихся и используемых на данный момент проприетарных программных средств.
The paper deals with the concept of free software, its characteristic features, features, as well as advantages and disadvantages. The reasons for the interest of government agencies in the implementation of policies aimed at the development of free software for the place of established proprietary tools are described. In chronological order, orders and orders of state bodies are given, which set the requirements for the implementation of measures aimed at implementing the software import substitution policy in the Russian Federation, as well as their results. A statistical analysis of the use of some software products related to free software is carried out. Based on this study, it is hypothesized about the reasons for the established interest of end users in the use of free software for daily needs. In the end, a conclusion is made about the prospects for introducing free software instead of the proprietary software that is currently available and used at the moment.
CYBERSPACE MAPPING AND INFORMATION PROTECTION
Authors: Остапенко Александр Григорьевич , Сердечный Алексей Леонидович , Трубицын Сергей Дмитриевич , Нархов Дмитрий Андреевич , Остапенко Владимир Юрьевич 
Published: October 2022

В статье рассматривается обеспечение ситуационной осведомленности об угрозах безопасности информации и компьютерных атаках с использованием центров реагирования на инциденты и информационных карт, включая ситуационные центры управления кибербезопасностью. Вышеуказанная осведомленность иллюстрируется информационными картами AРT-группировок, отражающими состав жертв и заинтересованных в них атаке строк; артефакты в коде вредоносного программного обеспечения; атрибуцию группировки на основании авторского стиля написания программных средств реализации компьютерных атак. В этой связи представлены общие планы информационных карт для разнообразных AРT-группировок. При этом обсуждается противодействие киберпреступности с использованием информационных карт. Обсуждается анализ финансовых операций злоумышленников в виртуальном пространстве за счет использования криптовалют. На примерах Blockchain и Bitcoin-транзакций рассматривается определение принадлежности криптокошельков. С помощью графа связей иллюстрируются вышеупомянутые транзакции. Предлагается также анализ вредоносного программного обеспечения как инструмента кибератак. В этой связи рассматривается информационная карта связей способов реализации компьютерных атак и объектов воздействия, построенная на основании онтологии.
The article discusses the provision of situational awareness of information security threats and computer attacks using incident response centers and information maps, including situational cybersecurity control centers. The aforementioned awareness is illustrated by information maps of the ART groups, reflecting: the composition of the victims and those interested in them in the attack of strings; artifacts in the code of malicious software; attribution of a grouping based on the author's style of writing software for implementing computer attacks. In this regard, general plans of information cards for various ART groups are presented. At the same time, countering cybercrime using information cards is discussed. The analysis of financial transactions of cybercriminals in the virtual space through the use of cryptocurrencies is discussed. Using the examples of Blockchain and Bitcoin transactions, he considers the determination of the ownership of crypto wallets. With the help of a link graph, the above transactions are illustrated. Analysis of malware as a cyber attack tool is also proposed. In this regard, an information map of connections between methods of implementing computer attacks and objects of influence, built on the basis of an ontology, is considered.