bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking insulin like growth factor-1 (IGF-1) rs6214 gene polymorphism and its serum level with risk of colorectal cancer
Authors: Kattan Shahad W. , Allah Azza Mohamed Kamel Abdu , Mohamed Kawthar Ibraheem , Alruwetei Abdulmohsen M. , Hegazy Amira H. , El Gayed Eman Masoud Abd 
Published: May 2022

Abstract
Background
Colorectal Cancer is found one of the most profound type of cancer around globe, affecting men and women with different ethnic and racial groups. Insulin-like growth factor 1 is known as peptide growth factor found to increase the proliferation of cell and prevent apoptosis. Insulin pathway might have linked with progression of colorectal cancer.

Methods
This study conducted on total 160 subjects, including 80 patients with colorectal cancer with 80 age and gender match controls. Clinical parameters were compared between the control group and Colorectal cancer group. Blood serum IGF-1 was quantified by using ELISA and IGF-1 rs6214(C/T) variations were investigated using TaqMan allelic discrimination assay.

Results
Blood serum level of Insulin growth factor-I (ng/ml) showed substantial association concerning groups while IGF-1 rs6214(C/T) genotype distribution observed increased in colorectal cancer patients as compared to controls with significant association. The variant TT and CT genotype frequency observed more common in cases as compared to control. However, the wild type CC genotype were common in cases used to compared with controls. The Odds Ratio reveal the risk of variant IGF-1 rs6214 T allele to increase 3 times compared to wild type allele.

Conclusion
The homozygous TT genotypes and T variant allele of IGF-1 rs6214(C/T) showed association with high serum Insulin growth factor level 1, may increase susceptibility to the colorectal cancer. This work will use to investigate the associations between Insulin-like growth factor 1 and rs6214(C/T) gene variant and blood serum level with the vulnerability to treat Colorectal. In summary, we have investigated the relationship between Insulin growth factor level hormone and colorectal cancer. Further studies are required to understand the association between colorectal cancer and polymorphism. However, this study can be serve as an informative study to uncover mechanisms behind main cause of colon cancer. Therefore, the genomic profiling of Insulin-like growth factor-1 can be helpful to treat colorectal cancer patients.
Quantum Cournot duopoly game with general isoelastic demand and asymmetric production costs
Authors: Zhang Xinli , Zhang Xiaohan , Hou Wen 
Published: May 2022

Abstract
This letter explores the quantum version of a Cournot duopoly game with general isoelastic demand and asymmetric production costs by applying Li-Du-Massar's minimal quantization rules, and it especially analyzes the existence region of quantum equilibrium, and the influences of quantum entanglement

, difference in marginal costs (k) and elasticity of demand

on the optimal profits of both firms. The results show that the existence region decreases with γ and k increasing. A larger elasticity of demand can destroy the profits of both firms. If

positive γ and k are more favourable to the profits of two firms. If

the first firm's profit increases with γ increasing for fixed k, but decreases with k increasing for fixed γ. The second firm's profit increases with k increasing for any fixed γ. As to the influences of γ on the second firm's profit, when k is less than a critical value, it increases with γ increasing, otherwise it decreases with γ increasing for fixed k.
Evaluation of renal microperfusion in hyperuricemic nephropathy by contrast-enhanced ultrasound imaging
Authors: He Li , Li Ze , Zhang Qunzi , Chen Yini , Gao Yihui , Chen Teng , Wang Niansong , Jiang Lixin , Fan Ying 
Published: May 2022

ABSTRACT
Diagnostic tools for the early detection of renal injury caused by hyperuricemia are still lacking. Here, we investigated whether contrast-enhanced ultrasound (CEUS) could be used as a diagnostic tool for hyperuricemic nephropathy (HN). In the HN rat model, CEUS detected a significant decline in renal cortical perfusion compared with that in control rats. Peak intensity (PI) values correlated significantly with serum KIM-1 levels and fibrosis scores in HN rats. An early decline in PI values was also observed in chronic kidney disease (CKD) stage 1 patients with HN compared with the controls (61.1±4.52 dB versus 65.80±7.10 dB) and correlated with renal function in the patients with HN. In contrast, an increase in time to reach PI values was detected in HN patients with stage 1 CKD (15.14±1.75 s versus 14.52±4.75 s) and was more pronounced in CKD stage 4 patients (67.32±3.29 s). CEUS was able to detect abnormal renal perfusion in early CKD with HN, which correlated with renal function decline, suggesting that CEUS could be used as a noninvasive tool for assessing renal function in patients with HN.
Hsp40 overexpression in pacemaker neurons delays circadian dysfunction in a Drosophila model of Huntington's disease
Authors: Prakash Pavitra , Pradhan Arpit Kumar , Sheeba Vasu 
Published: May 2022

ABSTRACT
Circadian disturbances are early features of neurodegenerative diseases, including Huntington's disease (HD). Emerging evidence suggests that circadian decline feeds into neurodegenerative symptoms, exacerbating them. Therefore, we asked whether known neurotoxic modifiers can suppress circadian dysfunction. We performed a screen of neurotoxicity-modifier genes to suppress circadian behavioural arrhythmicity in a Drosophila circadian HD model. The molecular chaperones Hsp40 and HSP70 emerged as significant suppressors in the circadian context, with Hsp40 being the more potent mitigator. Upon Hsp40 overexpression in the Drosophila circadian ventrolateral neurons (LNv), the behavioural rescue was associated with neuronal rescue of loss of circadian proteins from small LNv soma. Specifically, there was a restoration of the molecular clock protein Period and its oscillations in young flies and a long-lasting rescue of the output neuropeptide Pigment dispersing factor. Significantly, there was a reduction in the expanded Huntingtin inclusion load, concomitant with the appearance of a spot-like Huntingtin form. Thus, we provide evidence implicating the neuroprotective chaperone Hsp40 in circadian rehabilitation. The involvement of molecular chaperones in circadian maintenance has broader therapeutic implications for neurodegenerative diseases.
This article has an associated First Person interview with the first author of the paper.
Unconventional tonicity-regulated nuclear trafficking of NFAT5 mediated by KPNB1, XPOT and RUVBL2
Authors: Cheung Chris Y. , Huang Ting-Ting , Chow Ning , Zhang Shuqi , Zhao Yanxiang , Chau Mary P. , Chan Wing Cheung , Wong Catherine C. L. , Boassa Daniela , Phan Sebastien , Ellisman Mark H. , Yates John R. , Xu SongXiao , Yu Zicheng , Zhang Yajing , Zhang Rui , Ng Ling Ling , Ko Ben C. B. 
Published: May 2022

ABSTRACT
NFAT5 is the only known mammalian tonicity-responsive transcription factor with an essential role in cellular adaptation to hypertonic stress. It is also implicated in diverse physiological and pathological processes. NFAT5 activity is tightly regulated by extracellular tonicity, but the underlying mechanisms remain elusive. Here, we demonstrate that NFAT5 enters the nucleus via the nuclear pore complex. We found that NFAT5 utilizes a unique nuclear localization signal (NFAT5-NLS) for nuclear import. siRNA screening revealed that only karyopherin β1 (KPNB1), but not karyopherin α, is responsible for the nuclear import of NFAT5 via direct interaction with the NFAT5-NLS. Proteomics analysis and siRNA screening further revealed that nuclear export of NFAT5 under hypotonicity is driven by exportin-T (XPOT), where the process requires RuvB-like AAA-type ATPase 2 (RUVBL2) as an indispensable chaperone. Our findings have identified an unconventional tonicity-dependent nucleocytoplasmic trafficking pathway for NFAT5 that represents a critical step in orchestrating rapid cellular adaptation to change in extracellular tonicity. These findings offer an opportunity for the development of novel NFAT5 targeting strategies that are potentially useful for the treatment of diseases associated with NFAT5 dysregulation.
Adsorption Index Based on Hansen Solubility Parameters of Solutes, Solvents, and a Solid Surface and Its Application to Laser Desorption/Ionization Mass Spectrometry
Authors: Murase Masakazu , Yamada Yuri , Goto Yasutomo , Mizoshita Norihiro 
Published: May 2022

Abstract
Hansen solubility parameters (HSP) are useful for understanding the solubility and dispersibility of substances in liquids. This study aims at utilizing HSP to describe the affinity between solutes and solid surfaces in solutions. For this purpose, we designed the index “H” based on the HSP theory for predicting the adsorption behavior. In this study, the adsorption index H was used to estimate the desirable solvent compositions for preparing samples for laser desorption/ionization mass spectrometry (LDI-MS). The compositions for obtaining a high-intensity signal of analytes were estimated by selecting an appropriate H value from the relationship between the H and the solubility of the analytes predicted from the HSP. Four different pesticides (analytes) adsorbed on an organosilica film (LDI-MS substrate) were detected with high-intensity signals using the estimated solvent compositions. This study shows that the H is a useful parameter in the design of sample solutions for obtaining high-intensity signals in LDI-MS. Moreover, it is potentially useful for other applications that utilize molecular adsorption on solid surfaces.
Evaluation of selected semen parameters and biomarkers of male infertility – preliminary study
Authors: Kups Michal , Gill Kamil , Rosiak-Gill Aleksandra , Harasny Patryk , Machalowski Tomasz , Grabowska Marta , Kurzawa Rafal , Sipak Olimpia , Piasecka Malgorzata 
Published: May 2022

Background: Because the etiopathogenesis of male infertility is multifactorial our study was designed to clarify the relationship between standard semen parameters, testicular volume, levels of reproductive hormones and the fragmentation of sperm nuclear DNA (SDF). Methods: Patients (n = 130) were clustered as subjects: 1) with an abnormal volume (utrasonography) of at least one testis (<12 mL) or with a normal volume of testes and 2) with abnormal levels of at least one of the reproductive hormones (FSH, LH, PRL, TSH, total T – electrochemiluminescence method) or with normal hormonal profiles and 3) with high level of SDF (>30%), moderate (>15–30%) or low (≤15%) (sperm chromatin dispersion test). Results: In subjects with a decreased testicular volume and in subjects with abnormal levels of reproductive hormones, decreased basic semen parameters were found. Participants with abnormal testicular volume had a higher percentage of SDF and a higher level of FSH (Mann–Whitney U test). In turn, men with a high level of SDF had lower testicular volume and conventional sperm parameters than men with a low level of SDF (Kruskal–Wallis test). Conclusions: We showed that spermatogenesis disorders coexisted with decreased testicular volume and increased FSH levels. The disorders of spermatogenesis were manifested by reduced basic sperm characteristics and a high level of sperm nuclear DNA damage.
Intermediate Care Facilities for Individuals With Intellectual Disabilities: Does Ownership Type Affect Quality of Care?
Authors: Morantz Alison , Ross Leslie 
Published: May 2022

AbstractBecause many large, state-owned Intermediate Care Facilities for Individuals With Intellectual Disabilities (ICF/IIDs) have closed or downsized, their average size has fallen markedly, as has the number that are publicly owned. We probe the relationship between ownership type and four measures of care quality in ICF/IIDs. Data on deficiency citations suggest that for-profits underperform other ownership types, although data on complaints show no clear pattern. Meanwhile, data on staffing ratios and restrictive behavior management practices, based mostly on facility self-reports, generally tell the opposite story. Our results lend some credence to concerns regarding inadequate care in for-profit ICF/IIDs, while underscoring the importance of requiring ICF/IID operators to report more comprehensive, longitudinal data that are less prone to error and reporting bias.
A partially overdetermined problem in domains with partial umbilical boundary in space forms
Authors: Guo Jinyu , Xia Chao 
Published: May 2022

Abstract
In the first part of this paper, we consider a partially overdetermined mixed boundary value problem in space forms and generalize the main result in [11] to the case of general domains with partial umbilical boundary in space forms. Precisely, we prove that a partially overdetermined problem in a domain with partial umbilical boundary admits a solution if and only if the rest part of the boundary is also part of an umbilical hypersurface. In the second part of this paper, we prove a Heintze–Karcher–Ros-type inequality for embedded hypersurfaces with free boundary lying on a horosphere or an equidistant hypersurface in the hyperbolic space. As an application, we show an Alexandrov-type theorem for constant mean curvature hypersurfaces with free boundary in these settings.
Evaluation of a pneumatic tube system carrier prototype with fixing mechanism allowing for automated unloading
Authors: Märtens Cora M. , Schöpfel Juliane , Bollmann Stefan , Hannemann Anke , Zylla Stephanie , Dahl Mathilde Borg , Gauß Friederike , Schedl Josef , Nauck Matthias , Petersmann Astrid 
Published: May 2022

Abstract

Objectives
A carrier prototype by Aerocom® (Schwäbisch Gmünd, Germany) for pneumatic tube systems (PTS) is able to transport 9 blood tubes which are automatically fixed by closing the lid. In this study, we examined the influence of the transport on blood sample quality using the carrier prototype comparing to courier transport and a conventional carrier (AD160, Aerocom®).

Methods
Triplicate blood samples sets (1 lithium heparin, 1 EDTA, 1 sodium citrate) of 35 probands were split among the transportation methods: 1. courier, 2. conventional carrier, and 3. carrier prototype. After transport 51 measurands from clinical chemistry, hematology and coagulation were measured and compared.

Results
Overall, 49 of the investigated 51 measurands showed a good concordance among the three transport types, especially between the conventional carrier and the carrier prototype. Focusing on well-known hemolysis sensitive measurands, potassium showed no statistically significant differences. However, between courier and both carrier types lactate dehydrogenase (LDH) and free hemoglobin (fHb) showed statistically significant shifts, whereas the clinical impact of the identified differences was neglectable. The median concentration of fHb, for example, was 0.29 g/L (18 µmol/L), 0.31 g/L (19 µmol/L) and 0.32 g/L (20 µmol/L) for courier transport, conventional carrier and carrier prototype, respectively. These differences cannot be resolved analytically since the minimal difference (MD) for fHb is 0.052 g/L (3.23 µmol/L), at this concentration.

Conclusions
The carrier prototype by Aerocom® is suitable for transportation of diagnostic blood samples. The overall workflow is improved by decreasing hands-on-time on the ward and laboratory while minimizing the risk of incorrectly packed carriers.
Effect of post-compaction heating on characteristics of microcrystalline cellulose compacts
Authors: Gharaibeh Shadi F. , Obeidat Wasfy M. , Al-Zoubi Nizar 
Published: May 2022

Abstract
Compacts of microcrystalline cellulose were prepared at applied compression pressures of 21, 32, 43, 53, and 64 MPa. Compacts were subjected to elevated temperatures of 125°C, 150°C, and 175°C according to a 5-min heating program. The effect of these thermal treatments on compact volumes, densities, porosities, tensile strengths, and weight loss was determined. There was no change in the volumes of the compacts due to thermal treatments in most of the conditions. However, the densities of the compacts decreased while the porosities increased as a consequence of weight loss. Moreover, there was no difference (p > 0.05) between the tensile strengths of the compacts without heat treatment and those subjected to heat treatment in most of the conditions. This was indicative of the preservation of the magnitude of the interparticulate bonds in the compacts. Weight loss of the compacts was affected by the heat treatment temperature and their porosities.
The acoustics of plosives and the formation of prosodic structure in Polish
Authors: Wojtkowiak Ewelina , Schwartz Geoffrey 
Published: May 2022

AbstractThe aim of this acoustic study of voiced and voiceless word-initial plosives is to establish the nature of the relationship between prosodic positions, accent, and segmental phonetics in Polish. Four different acoustic parameters were investigated (VOT, pitch, F1, and preceding vowel’s duration). The results show rather modest effects of prosodic position. The findings are interpreted with reference to the prosodic typology posited in the Onset Prominence representational framework (OP), in which prosodic domains are not imposed from above but rather are formed according to opposing mechanisms of ‘submersion’ and ‘adjunction’. The findings support the claim that Polish belongs to the latter category, in which only modest effects of position are expected.
A compact S-band band-pass filter with ultra-wide stopband
Authors: Xu Qian-kun , Zhang Zhong-nan , Wu Xiao-hua , Wang Jue-zhe , Peng Lin 
Published: May 2022

Abstract
A novel compact S-band band-pass filter (BPF) with ultra-wide stopband is presented. The proposed filter mainly consists of three parts, a novel crossed resonator, parallel-coupled microstrip lines, and defect ground structures (DGSs). The resonator is constructed by three capacitive open stubs, while a defect is etched in the center stub to eliminate high frequency harmonics. The parallel-coupled microstrip lines are mainly used to improve the passband and the roll-off rate (the ratio of height to width of the filter transition band). And the DGSs are utilized to improve the stopband performances. The proposed BPF has the merits of compactness, good insertion loss and good stopband characteristic. The measured 3 dB operating band is 1.80–4.03 GHz (76.5% at f
0 = 2.92 GHz), The upper out-of-band suppression was better than 20 dB for the frequency up to 20 GHz (6.33f
0), and the upper roll-off rate reaches 75.59 dB/GHz.
Phosphorus removal from aqueous solution by adsorption using wetland-based biochar: Batch experiment
Authors: Xu QiaoLing , Wang Li , Tan Minxia , Wang Xiaolei , Li Jiajie , Geng Hejun 
Published: May 2022

Abstract
This article experiments wetland-based biochar as an effective adsorbent for phosphorus removal. In this experiment, four common wetland plants, canna (C), umbrella palm (U), bamboo reed (B), and Thalia dealbata (T), were used as the main raw materials. Twelve kinds of biochar (C300, C500, C700, U300, U500, U700, B300, B500, B700, T300, T500, and T700) were obtained at three pyrolysis temperatures (300°C, 500°C, and 700°C). The results show that canna (C) and umbrella palm (U) are more suitable as raw materials for phosphorus removal using biochar. If bamboo reed (B) and Thalia dealbata (T) are used as raw materials for phosphorus removal using biochar, there is a greater risk of phosphorus release. With the increase of pyrolysis temperature (700°C > 500°C > 300°C), there is an increasing trend of phosphorus adsorption effect. The theoretical maximum adsorption capacity of C700, U700, and C500 was 39.24, 7.08, and 7.26 mg P·g−1 at an initial concentration of 50 mg·L−1 phosphorus, respectively. The theoretical adsorption capacity of C700 (Q
max = 39.24 mg P·g−1) was much higher than that of the general modified adsorption materials. It also has a larger tolerance range to pH (3–11). The results of kinetic model fitting showed that the adsorption mechanism of C700, U700, and C500 on phosphorus can be better simulated by intra-particle diffusion and Elovich model, and the adsorption mechanism includes surface adsorption and intra-particle diffusion. The fitting of isothermal adsorption model showed that Langmuir–Freundlich equation is more suitable for the description of adsorption characteristics of C700, U700, and C500, and the fitting coefficient R
2 is 0.9928, 0.9949, and 0.9897, respectively. It indicates that the adsorption of phosphorus on C700, U700, and C500 has a balance of uniform and nonuniform surface, and monolayer and multilayer adsorption could occur. The results from this work demonstrated that the biochar obtained from canna at 700°C has good adsorption and phosphorus removal potential without modification, and it can be used as the preferred biochar for phosphorus removal of high concentration with large pH changes. In the final validation experiment, the phosphorus removal rate of C700 was up to 77.4% on the treatment of actual phosphorus containing wastewater.
Quantitative visualization study on the physical movement and gastric emptying of diced carrot particle in a transparent rat stomach-duodenum model
Authors: Feng Jiajun , Wu Peng , Chen Xiao Dong 
Published: May 2022

Abstract
In this study, a transparent soft-elastic silicone rat stomach model was prepared to visualize the gastric movement and emptying of one individual diced carrot in a dynamic in vitro rat stomach system. The influences of the viscosity of solution medium, the pattern of gastric peristalsis and the extraction rate of the emptying pump on the location and gastric residence time of the carrot particle were examined. A proper medium viscosity could promote the emptying of the carrot particle. Compared to the combined actions of plate and roller, gastric residence time of the carrot particle was reduced from 32.3 to 19.8 min under the single plate compression. This time was also shortened from 34.8 to 12.3 min when the extraction rate of emptying pump was changed from 100 mL/min to 400 mL/min. Knowledge gained from this work is unique and may provide new insights for optimizing biomimic gastrointestinal models.
Typical strength of asphalt mixtures compacted by gyratory compactor
Authors: Rasool Dina A. , Hilal Miami M. , Fattah Mohammed Y. 
Published: May 2022

AbstractDesign of asphalt mixes and quality testing is influenced by the laboratory compaction procedure. Laboratory specimens must be manufactured in a way that suitably resembles field compaction for a performance test to give reliable mechanical properties. The internal structure of the mixture, which is referred to in this article as the spread of aggregate and air voids, provides the basis for the simulation. Gyratory compaction uses a kneading effort to produce cylindrical specimens. The goal of the present article is to determine the required strength for asphalt mix compaction of 40–50 per surface. This look was achieved with three distinct types of filler material and two kinds of sand. The asphalt mixture’s compressibility was tested. By adding the cumulative energy expended during gyratory specimen compaction to the compression data, the force applied to the sample during gyrations may be calculated. The relation between the number of gyrations and forces demonstrates pressure resistance. The measured fore force vs number of gyrations for combinations containing limestone, cement, and fly ash as fill materials was presented. The force required to compact the six bituminous materials was found to be influenced by the filler content. As the number of gyrations increases, its compaction properties change until it achieves a steady state. Except for the asphalt–cement mixture, compaction strength in mixes containing river sand requires less strength than compaction strength in mixes containing crushed sand.