bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel technique of flexible endoscopic therapy of Zenker’s diverticulum using a pulsed Holmium laser—a retrospective single-center analysis
Authors: Singhartinger Franz , Gantschnigg Antonia , Mühlbacher Iris , Wagner Andrej , Koch Oliver , Emmanuel Klaus , Holzinger Josef 
Published: November 2022

Abstract
Background
In recent years, flexible endoscopic therapy of Zenker’s diverticulum seems to become the standard approach. The aim of this study was to assess the safety, efficacy and short-term outcome of flexible endoscopic diverticulotomy of Zenker’s diverticulum with a pulsed Holmium laser (PHL).

Patients and methods
All patients treated with endoscopic laser-diverticulotomy using a PHL between February 2013 and November 2021 at the University Hospital Salzburg were extracted from our prospectively maintained endoscopic database. Demographic data, size of Zenker’s diverticulum, procedure duration, complications, short-term outcome and rate of recurrence were evaluated.

Results
In the study period, 45 procedures in 36 patients were performed. Mean depth of the Zenker diverticulum was 21 mm (10–60 mm), mean procedure time was 31 min (15–60 min), intraprocedural adverse events occurred in 2 out of 45 patients (5%) which were both managed endoscopically, post-procedural stenosis occurred in 1 patient (2%). In the follow-up examinations (mean follow-up after 6.4 months), 27 out of 36 patients (75%) were symptom-free, 6 patients (17%) reported an improvement of dysphagia. 3 patients (9%) suffered from persistent dysphagia. After initial symptom relief, a recurrent diverticulum occurred in 5 patients. Endoscopic re-intervention with PHL was done in these cases.

Conclusions
Flexible endoscopic treatment of primary and recurrent Zenker’s diverticulum using a PHL is a promising, safe and effective treatment with, in our opinion, technical advantages in comparison to the CO2 laser. Further controlled prospective trials are needed.
Embryonic mouse medial neocortex as a model system for studying the radial glial scaffold in fetal human neocortex
Authors: Vaid Samir , Heikinheimo Oskari , Namba Takashi 
Published: November 2022

AbstractNeocortex is the evolutionarily newest region in the brain, and is a structure with diversified size and morphology among mammalian species. Humans have the biggest neocortex compared to the body size, and their neocortex has many foldings, that is, gyri and sulci. Despite the recent methodological advances in in vitro models such as cerebral organoids, mice have been continuously used as a model system for studying human neocortical development because of the accessibility and practicality of in vivo gene manipulation. The commonly studied neocortical region, the lateral neocortex, generally recapitulates the developmental process of the human neocortex, however, there are several important factors missing in the lateral neocortex. First, basal (outer) radial glia (bRG), which are the main cell type providing the radial scaffold to the migrating neurons in the fetal human neocortex, are very few in the mouse lateral neocortex, thus the radial glial scaffold is different from the fetal human neocortex. Second, as a consequence of the difference in the radial glial scaffold, migrating neurons might exhibit different migratory behavior and thus distribution. To overcome those problems, we propose the mouse medial neocortex, where we have earlier revealed an abundance of bRG similar to the fetal human neocortex, as an alternative model system. We found that similar to the fetal human neocortex, the radial glial scaffold, neuronal migration and neuronal distribution are tangentially scattered in the mouse medial neocortex. Taken together, the embryonic mouse medial neocortex could be a suitable and accessible in vivo model system to study human neocortical development and its pathogenesis.
Marktdesign für die Gasmangellage
Authors: Ockenfels Axel 
Published: November 2022

ZusammenfassungBisher ist unklar, wer wie viel Gas zu welchem Preis in einer Mangellage in Deutschland bekommt, wenn der Regulierer rationieren muss. Dies droht die Anreize in und im Vorfeld einer Mangellage zu verwässern. In diesem Beitrag wird die potenziell hilfreiche Rolle eines Zertifikatsmarktes für die Allokation und Bepreisung in der Mangellage in den Blick genommen.
Handgrip strength is associated with learning and verbal fluency in older men without dementia: insights from the NHANES
Authors: Prokopidis Konstantinos , Giannos Panagiotis , Ispoglou Theocharis , Kirk Ben , Witard Oliver C. , Dionyssiotis Yannis , Scott David , Macpherson Helen , Duque Gustavo , Isanejad Masoud 
Published: November 2022

Abstract
Low handgrip strength, a hallmark measure of whole-body strength, has been linked with greater odds of cognitive decline and dementia; however, conflicting findings, which could be due to population characteristics and choice of tools, such for the assessment of handgrip strength and cognitive function domains, also exist. Therefore, we examined the relationship of handgrip strength with a comprehensive list of tests to assess domains of cognitive function using a representative sample of US older men and women without neurodegenerative disorders such as dementia. We analyzed cross-sectional data from the US National Health and Nutrition Examination Survey (NHANES) between 2011 and 2014, with a study cohort of 777 older adults (380 men and 397 women) above 60 years of age. Handgrip strength was assessed using a handgrip dynamometer, while cognitive function was assessed through the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) Word List Learning Test (WLLT), Word List Recall Test (WLRT), Intrusion Word Count Test (WLLT-IC and WLRT-IC), the Animal Fluency Test (AFT), and the Digit Symbol Substitution Test (DSST). Sex-stratified multiple linear regression analyses were performed upon covariate adjustment for age, ethnicity, socio-economic status, education, medical history, body mass index, physical activity, energy, protein, and alcohol intake. Maximal handgrip strength was positively associated with cognitive function scores, including CERAD WLLT (P = 0.009, R2 = 0.146) and AFT (P = 0.022, R2 = 0.024) in older men, but not in women (CERAD WLLT: P = 0.253, AFT: P = 0.370). No significant associations with CERAD WLLRT (men: P = 0.057, women: P = 0.976), WLLT-IC (men: P = 0.671, women: P = 0.869), WLLRT-IC (men: P = 0.111, women: P = 0.861), and DSST (men: P = 0.108, women: P = 0.091) were observed. Dose–response curves exhibited a prominent linear relationship between all significant associations after covariate adjustment, with no indication of a plateau in these relationships. In conclusion, higher handgrip strength was independently associated with better learning ability for novel verbal information and verbal fluency in US men over the age of 60 and without dementia. Longitudinal studies are required to confirm whether muscle strength independently predicts cognitive function changes in older adults in a sex-specific manner, and whether this connection is affirmed to the possibility of reverse causation due to declines in physical activity levels in the preclinical phase of dementia.
A framework for the bi-level optimization of a generic transport aircraft fuselage using aeroelastic loads
Authors: Sinha Kautuk , Klimmek Thomas 
Published: November 2022

AbstractThe aeroelastic loads and design processes at the German Aerospace Center, Institute of Aeroelasticity in the framework of multi-disciplinary optimization are constantly evolving. New developments have been made in the in-house model generation tool ModGen, which allow us to create detailed fuselage models for preliminary design. As a part of the subsequent developments to integrate the fuselage structure in our aeroelastic design process, a new framework for optimizing the fuselage structure has been developed. The process is based on a bi-level optimization approach which follows a global–local optimization methodology to simplify a large optimization problem. A sub-structuring procedure is used to define stiffened panels as independent structures for local optimization. The panels are sized with stress and buckling constraints with consideration of several aeroelastic load cases. Furthermore, in this paper, we present a physical sub-structure grouping process which enables reduced number of panel optimizations and saves considerable computational effort with little compromise in the solution accuracy.
Chart-Based Granular Slope Stability Assessment Using the Modified Mohr–Coulomb Criterion
Authors: Zhou Jian , Li Chuanqi , Asteris Panagiotis G. , Shi Xiuzhi , Armaghani Danial Jahed 
Published: November 2022

AbstractThere are usually two types of slopes in nature: soil and rock. However, the granular slope has gradually come into view and has caused concern. In this paper, a modified Mohr–Coulomb (MC) criterion has been proposed to estimate the strength parameters of medium materials using a new parameter ($$\tau_{0}$$

τ
0

) instead of the traditional MC parameter (c). Meanwhile, there is a new stability chart of a granular slope whose core is the dimensionless stability number Ns and dimensionless coefficient DR based on a modified MC criterion to estimate the safety factor of a granular slope preliminarily when the geometric and strength parameters of the slope are determined. A practical case is introduced to test the results, showing that the stability chart proposed in this paper is applicable to granular slopes. The research content and the proposed new viewpoints are intended to offer preliminary judgments on the stability analysis of granular slopes and provide guidance for the stability analysis and construction design of granular slope engineering.
Ecotoxicity of selected carbon-based nanomaterials
Authors: Gamoń F. , Ziembińska-Buczyńska A. , Łukowiec D. , Tomaszewski M. 
Published: November 2022

AbstractThe widespread use of the nanomaterials increases the emission of nano-pollutants into the water. Carbon nanomaterials are particularly interesting. They are characterized by relatively stable structure, which makes them able to migrate and accumulate in the environment. Therefore, the aim of this study was to determine the potential toxicity at the different trophic levels of four selected carbon nanostructures: graphene oxide (GO), reduced graphene oxide (rGO), multi-walled carbon nanotubes (MWCNTs) and oxidized multi-walled carbon nanotubes (f-MWCNTs) on indicators at three trophic levels. Producers was represented by Lemna minor in growth inhibition test. The ecotoxicological effect for consumers was estimated by acute tests on Artemia franciscana, Brachionus calyciflorus and Thamnocephalus platyurus, while the acute toxicity on decomposers was studied on bacteria Escherichia coli. Results show that the short-term exposure on MWCNTs, f-MWCNTs, GO and rGO can be toxic at three trophic levels. The influence of the tested materials was much higher for the consumers, than for the producers. The lowest toxicity from all researched carbon-based nanomaterials was presented by GO. Moreover, generation of high reactive form of oxygen, mechanical damage of cell wall and membrane is one of the main toxicity mechanism; thus, the toxicity depends heavily of the dose and the shape of the nanomaterials.
The Influence of the Madden–Julian Oscillation on the Wet Season Rainfall over Saudi Arabia
Authors: Almazroui Mansour 
Published: November 2022

AbstractThe influence of Madden–Julian oscillation (MJO) is examined on intraseasonal rainfall variability during the wet season (November–April) by using the real-time multivariate (RMM) MJO index, ERA5 reanalysis, and daily observed rainfall dataset from 26 stations in Saudi Arabia for the period 1985–2021. The MJO 8 phases are categorized into wet (phases 1, 2, 7 and 8) and dry (phases 3, 4, 5, and 6) based on the Saudi Arabian intraseasonal rainfall characteristics associated with MJO phases. It is observed that 41% (46%) of total (extreme) rainfall events occur during the MJO wet phases, while only 23% (18%) of such events occur during MJO dry phases. The intraseasonal variability signals are isolated from daily dataset by applying a 30- to 90-day period bandpass filter. The analyses are validated by constructing composites of daily filtered precipitation anomalies during MJO 8 phases. The physical mechanism indicates that the significant intraseasonal wetter conditions are linked with enhanced easterly and southeasterly moisture convergence over Saudi Arabia from the Arabian Sea. The atmospheric cyclonic circulation anomalies during the wet phases favor more moisture convergence and vertical moisture advection, which may lead to enhanced convection and rainfall. However, during the dry phases, anticyclonic circulation anomalies enhance moisture divergence and reduce vertical moisture advection and consequently suppress the convection and rainfall activity over Saudi Arabia. The analyses show that the intraseasonal rainfall variability over Saudi Arabia is significantly influenced by the MJO during the wet season. These findings have important implications for sub-seasonal rainfall forecasting in Saudi Arabia.
Environments of evolved massive stars: evidence for episodic mass ejections
Authors: Kraus M. , Cidale L. S. , Arias M. L. , Torres A. F. , Kolka I. , Maravelias G. , Nickeler D. H. , Glatzel W. , Liimets T. 
Published: November 2022

AbstractThe post-main sequence evolutionary path of massive stars comprises various transition phases, in which the stars shed large amounts of material into their environments. Our studies focus on two of them: B[e] supergiants and yellow hypergiants, for which we investigate the structure and dynamics within their environments. We find that each B[e] supergiant is surrounded by a unique set of rings or arc-like structures. These structures are either stable over time or they display high variability, including expansion and dilution. In contrast, yellow hypergiants are embedded in multiple shells of gas and dust. These objects are famous for their outburst activity. Moreover, the dynamics in their extended atmospheres imply an enhanced pulsation activity prior to outburst. The physical mechanism(s) leading to episodic mass ejections in these two types of stars is still uncertain. We propose that strange-mode instabilities, excited in the inflated envelopes of these objects, play a significant role.
Magnetised gas nebulae of evolved massive stars
Authors: Meyer Dominique M.-A. 
Published: November 2022

AbstractMassive stars are amongst the rarest but also most intriguing stars. Their extreme, magnetised stellar winds induce, by wind-ISM interaction, famous multi-wavelengths circumstellar gas nebulae of various morphologies, spanning from large-scale wind bubbles to stellar wind bow shocks, rings and bipolar shapes. We present two- and three-dimensional magneto-hydrodynamical (MHD) simulations of the circumstellar medium of such massive stars at different phase of their evolution. Particularly, we investigate the stability properties of 3D MHD bow shock nebulae around the runaway red supergiant stars IRC-10414 and Betelgeuse. Our results show that their astrospheres are stabilised by an organised, non-parallel ambient magnetic field. These findings suggest that Betelgeuse’s bar is of interstellar origin. Last, we explore the circular aspect of the young nebula around the Wolf-Rayet stars. It is found that Wolf-Rayet nebulae are not affected by the ISM gas distribution in which the stellar objects lie, even in the case of fast stellar motion: as testifies the ring-like surroundings of the Milky Way’s fastest Wolf-Rayet star, WR124. The morphology of these nebulae is tightly related to their pre-Wolf-Rayet wind geometry and to their phase evolution transition properties, which can generate bipolar shapes. We will further discuss their diffuse projected emission by means of radiative transfer calculations and show that the projected diffuse emission can appear as bipolar structures as in NGC6888.
Simulations of Colliding Winds in Massive Binary Systems with Accretion
Authors: Kashi Amit , Michaelis Amir 
Published: November 2022

AbstractWe run numerical simulations of massive colliding wind binaries, and quantify the accretion onto the secondary under different conditions. We set 3D simulation of a LBV–WR system and vary the LBV mass loss rate to obtain different values of wind momentum ratio η. We show that the mean accretion rate for stationary systems fits a power law Macc∝ η–1.6 for a wide range of η, until for extremely small η saturation in the accretion is reached. We find that the stronger the primary wind, the smaller the opening angle of the colliding wind structure (CWS), and compare it with previous analytical estimates. We demonstrate the efficiency of clumpy wind in penetrating the CWS and inducing smaller scale clumps that can be accreted. We propose that simulations of colliding winds can reveal more relations as the ones we found, and can be used to constrain stellar parameters.
Route towards complete 3D hydro-chemical simulations of companion-perturbed AGB outflows
Authors: Maes Silke , Siess Lionel , Homan Ward , Malfait Jolien , De Ceuster Frederik , Ceulemans Thomas , Donné Dion , Esseldeurs Mats , Decin Leen 
Published: November 2022

AbstractLow- and intermediate mass stars experience a significant mass loss during the last phases of their evolution, which obscures them in a vast, dusty envelope. Although it has long been thought this envelope is generally spherically symmetric in shape, recent high-resolution observations find that most of these stars exhibit complex and asymmetrical morphologies, most likely resulting from binary interaction. In order to improve our understanding about these systems, theoretical studies are needed in the form of numerical simulations. Currently, a handful of simulations exist, albeit they mainly focus on the hydrodynamics of the outflow. Hence, we here present the pathway to more detailed and accurate modelling of companion-perturbed outflows with, by discussing the missing but crucial physical and chemical processes. With these state-of-the-art simulations we aim to make a direct comparison with observations to unveil the true identity on the embedded systems.
MATISSE first pictures of dust and molecules around R Sculptoris
Authors: Drevon J. , Millour F. , Cruzalèbes P. , Paladini C. , Hron J. , Meilland A. , Allouche F. , Aringer B. , Berio P. , Danchi W.C. , Hocdé V. , Hofmann K.-H. , Lagarde S. , Lopez B. , Matter A. , Petrov R. , Robbe-Dubois S. , Schertl D. , Stee P. , Vakili F. , Varga J. , Waters R. , Weigelt G. , Woillez J. , Wittkowski M. , Zins G. 
Published: November 2022

AbstractCarbon-rich dust is known to form in the atmosphere of the semiregular variable star R Sculptoris. Such stardust, as well as the molecules and gas produced during the lifetime of the star, will be spread into the Galaxy via the mass-loss process. Probing this process is crucial to understand the chemical enrichment of the Galaxy. R Scl was observed using the ESO/VLTI MATISSE instrument in December 2018. Here we show the first images of the star between 3 and 10 R*. Using the complementary MIRA 3D image reconstruction and the RHAPSODY 1D intensity profile reconstruction code, we reveal the location of molecules and dust in the close environment of the star. Indeed, the C2H2 and HCN molecules are spatially located between 1 and 3.4 R* which is much closer to the star than the location of the dust. The R Scl spectrum is fitted by molecules and a dust mixture of 90% of amorphous carbon and 10% of silicone carbide. The inner boundary of the dust envelope is estimated by DUSTY at about 4.6 R*. We derive a mass-loss rate of 1.2 ± 0.4 × 10−6M⊙ yr−1however no clear SiC forming region has been detected in the MATISSE data.
Can pre-supernova winds from massive stars enrich the interstellar medium with nitrogen at high redshift?
Authors: Roy Arpita , Krumholz Mark R. , Dopita Michael A. , Sutherland Ralph S. , Kewley Lisa J. , Heger Alexander 
Published: November 2022

AbstractUnderstanding the nucleosynthetic origin of nitrogen and the evolution of the N/O ratio in the interstellar medium is crucial for a comprehensive picture of galaxy chemical evolution at high-redshift because most observational metallicity (O/H) estimates are implicitly dependent on the N/O ratio. The observed N/O at high-redshift shows an overall constancy with O/H, albeit with a large scatter. We show that these heretofore unexplained features can be explained by the pre-supernova wind yields from rotating massive stars (M≳10M⊙,ν/νcrit≳0.4). Our models naturally produce the observed N/O plateau, as well as the scatter at low O/H. We find the scatter to arise from varying star formation efficiency. However, the models that have supernovae dominated yields produce a poor fit to the observed N/O at low O/H. This peculiar abundance pattern at low O/H suggests that dwarf galaxies are most likely to be devoid of SNe yields and are primarily enriched by pre-supernova wind abundances.
Effects of wind mass-loss on the observational properties of Type Ib and Ic supernova progenitors
Authors: Yoon Sung-Chul , Jung Moo-Keon , Jin Harim , Kim Hyun-Jeong 
Published: November 2022

AbstractProgenitors of Type Ib and Ic supernovae (SNe) are stripped envelope stars and provide important clues on the mass-loss history of massive stars. Direct observations of the progenitors before the supernova explosion would provide strong constraints on the exact nature of SN Ib/Ic progenitors. Given that stripped envelope massive stars can have an optically thick wind as in the case of Wolf-Rayet stars, the influence of the wind on the observational properties needs to be properly considered to correctly infer progenitor properties from pre-SN observations. Non-LTE stellar atmosphere models indicate that the optical brightness could be greatly enhanced with an optically thick wind because of lifting-up of the photosphere from the stellar surface to the wind matter, and line and free-free emissions. So far, only a limited number of SN Ib/Ic progenitor candidates have been reported, including iPTF13bvn, SN 2017ein and SN 2019yvr. We argue that these three candidates are a biased sample, being unusually bright in the optical compared to what is expected from typical SN Ib/Ic progenitors, and that mass-loss enhancement during the final evolutionary stage can explain their optical properties.
How did the Stellar Winds of Massive Stars influence the Surrounding Environment in the Galactic Center?
Authors: Zhang Mengfei , Li Zhiyuan 
Published: November 2022

AbstractIn the Galactic center, there are many massive stars blowing strong stellar winds, which will strongly influence the surrounding environment and even the Galactic feedback. The Galactic center is quiescent at present, so the unique continuous energy input source is the massive star, consequently giving rise to many special features, such as the radio bubbles, the X-ray chimneys, the non-thermal filaments and high-metallicity abundance. However, it is difficult to quantify their contributions due to the complex environment in this region, and the past supernovae and Sgr A* activity are also important factors shaping these features. In this work, we discuss some structures possibly related to the stellar winds and perform preliminary simulations to study their evolution. We conclude the stellar winds can obviously influence a large scale ∼ 100 pc, and can possibly influence a larger scale environment indirectly.