bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal management of power sharing based on hybrid fuzzy logic-genetic algorithm of water desalination system integrated with renewable energy
Authors: Zgalmi Abir , rhouma Amine Ben , cherif habib , Belhadj Jamel 
Published: September 2022

Abstract
Coupling renewable energy sources with reverse osmosis desalination systems offers a suitable solution to freshwater scarcity problem, especially in regions suffering from hydraulic and electrical crisis. In this context, design, feasibility and performance evaluation of a standalone brackish water reverse osmosis desalination unit powered with hybrid PV/Wind sources in isolated community have been investigated. In order to reduce the cost of investment and maintenance, the proposed system was based on hydraulic storage in a water tower instead of electrochemical storage. This study aims to optimize the power sharing of the generated power between the motor-pumps while respecting constraints and maximize the produced freshwater quantity. For this purpose, a genetic algorithm optimization of the fuzzy-logic membership functions is proposed. First, a simple fuzzy logic system was used to improve the power sharing between the hydro mechanical processes. Then, an offline optimization of the developed fuzzy-logic using genetic algorithm was applied. Finally, to validate the developed optimal energy management strategy performance, single fuzzy-logic and hybrid fuzzy logic-genetic algorithm energy management system results are compared for a real power profiles. The optimized fuzzy-logic energy management strategy demonstrated its high performance in improving the system energy efficiency with the reduction of the consumed energy (gain of 7.1% in October (Autonm)), and enhance the permeate water production (gain of 2.96% during a week) compared with the energy management based only fuzzy-logic strategy.
Trends of antihypertensive, antidiabetic, and non-steroidal anti-inflammatory drugs use among the Health Workers Cohort Study, Mexico 2004 to 2018.
Authors: Ortega-Montiel Janinne , Montoya Alejandra , Soria-Saucedo René , Gallegos-Carrillo Katia , Ramírez-Palacios Paula , Salmerón Jorge , Salazar-Martinez Eduardo 
Published: September 2022

Abstract
Purpose
Hypertension and Type 2 Diabetes (T2D) are the most prevalent non-communicable diseases in Mexico and worldwide. The principal chronic management therapy is daily oral medication according to international practice management guidelines. We aim to describe the trends of the utilization of antihypertensive, antidiabetic, and non-steroidal anti-inflammatories drugs (NSAID) among Mexican adult population from 2004-2018 through three waves.
Methods
We conducted a longitudinal analysis using data from the Health Workers Cohort Study (HWCS), males and females, aged > 18 years. The prevalence of chronic diseases and utilization for every kind of antihypertensive, antidiabetic, and NSAIDs (measured by self-reported utilization) were calculated in each of the three study waves, and trends were analyzed using Fisher’s exact test.
Results
Hypertension prevalence increased from 19.8 to 30.3%, same as Diabetes prevalence from 7.0 to 12.8% through fourteen years of follow-up. The proportion of patients using beta-blockers and angiotensin receptor blocker II increased, same as the self-reported dual therapy. Regarding T2D, the prevalence of metformin utilization rose to 83.9%. The utilization of common NSAIDs, mainly for muscular pain, remained around 13 to 16%.
Conclusions
Our findings showed markedly changing utilization drugs prevalence for hypertension and T2D between 2004 and 2018, and consistent utilization of NSAIDs (acetaminophen mainly) in the adult Mexican population.
Non-Small-Cell Lung Cancer Promotion by Air Pollutants
Authors: Swanton Charles , Hill William , Lim Emilia , Lee Claudia , Weeden Clare , Augustine Marcellus , Chen Kezhong , Kuan Feng-Che , Marongiu Fabio , Evans Edward , Moore David , Rodrigues Felipe , Maldegem Febe van , Boumelha Jesse , Veeriah Selvaraju , Rowan Andrew , Naceur-Lombardelli Cristina , Karasaki Takahiro , Sivakumar Monica , Caswell Deborah , Nagano Ai , Ryu Min Hyung , Huff Ryan , Li Shijia , Magness Alastair , Suarez-Bonnet Alejandro , Priestnall Simon , Lüchtenborg Margreet , Lavelle Katrina , Pethick Joanna , Hardy Steven , McRonald Fiona , Lin Meng-Hung , Troccoli Clara , Ghosh Moumita , Miller York , Merrick Daniel , Keith Robert , Bakir Maise Al , Bailey Chris , Saal Lao , Chen Yilun , George Anthony , Abbosh Chris , Kanu Nnennaya , Lee Se-Hoon , McGranahan Nicholas , Berg Chistine , Grönroos Eva , Downward Julian , Jacks Tyler , Carlsten Christopher , Malanchi Ilaria , Hackshaw Allan , Litchfield Kevin , Jamal-Hanjani Mariam , DeGregori James 
Published: September 2022

Abstract
Environmental carcinogenic exposures are major contributors to global disease burden yet how they promote cancer is unclear. Over 70 years ago, the concept of tumour promoting agents driving latent clones to expand was first proposed. In support of this model, recent evidence suggests that human tissue contains a patchwork of mutant clones, some of which harbour oncogenic mutations, and many environmental carcinogens lack a clear mutational signature. We hypothesised that the environmental carcinogen, <2.5μm particulate matter (PM2.5), might promote lung cancer promotion through non-mutagenic mechanisms by acting on pre-existing mutant clones within normal tissues in patients with lung cancer who have never smoked, a disease with a high frequency of EGFR activating mutations. We analysed PM2.5 levels and cancer incidence reported by UK Biobank, Public Health England, Taiwan Chang Gung Memorial Hospital (CGMH) and Korean Samsung Medical Centre (SMC) from a total of 463,679 individuals between 2006-2018. We report associations between PM2.5 levels and the incidence of several cancers, including EGFR mutant lung cancer. We find that pollution on a background of EGFR mutant lung epithelium promotes a progenitor-like cell state and demonstrate that PM accelerates lung cancer progression in EGFR and Kras mutant mouse lung cancer models. Through parallel exposure studies in mouse and human participants, we find evidence that inflammatory mediators, such as interleukin-1ꞵ, may act upon EGFR mutant clones to drive expansion of progenitor cells. Ultradeep mutational profiling of histologically normal lung tissue from 247 individuals across 3 clinical cohorts revealed oncogenic EGFR and KRAS driver mutations in 18% and 33% of normal tissue samples, respectively. These results support a tumour-promoting role for PM acting on latent mutant clones in normal lung tissue and add to evidence providing an urgent mandate to address air pollution in urban areas.
Maternal anxiety forecasts shorter prolongation of pregnancies complicated by early-onset preeclampsia
Authors: Esch Joris J.A. van , Bolte Antoinette C. , Spaanderman Marc E.A. , Vandenbussche Frank P.H.A. , de Weerth Carolina , Beijers Roseriet 
Published: September 2022

Abstract
Purpose: In early-onset preeclampsia, each additional day of pregnancy prolongation reduces offspring infant mortality about 9%. We evaluated if maternal stress at admission to hospital for early-onset preeclampsia predicted admission-to-delivery intervals in days.
Methods: This prospective, longitudinal cohort-study involved 15 singleton pregnancies with a diagnosis of preeclampsia before 34 weeks gestation with intended expectant management. Upon hospital admission, maternal psychological stress was assessed with questionnaires and physiological stress with hair cortisol. Hair samples were analysed in three hair segments representing the preconception period, and the first and second trimester of pregnancy.
Results: Mean pregnancy prolongation was 15 days. Higher maternal anxiety at hospital admission significantly correlated with shorter admission-to-delivery intervals (r=-.64, p=.01). Chronically increased hair cortisol concentrations (i.e., from preconception through the second trimester) of pregnancy tended to be related to shorter admission-to-delivery intervals (p=.06).
Conclusion: Higher reported anxiety is, and chronically high hair cortisol tended to be, related with fewer days of prolongation from admission to delivery in women with early-onset preeclampsia. These findings suggest that maternal stress might be a potential determinant of disease progression. Future research into early innovative stress-reducing interventions for early-onset preeclampsia may shed more light on the etiology and treatment of this disease.
Climate change shifts the habitat suitability of range-restricted bird species (Catreus wallichii) in the Himalayan ecosystem: evidence from the Indian Himalayan Ecosystem
Authors: Singh Hukum , Kumar Narendra , Singh Ranjeet , Kumar Manoj 
Published: September 2022

Abstract
Climate change affects ecosystems' functioning and composition by changing living organisms' habitats under adverse climate conditions. India's Himalayan ecosystem (IHE) is more sensitive and vulnerable to climate change. Changes in the habitats of range-restricted and vulnerable avifauna of IHE under climate change are not well understood. In the present study, we used ensemble species distribution modeling to delineate the climate-driven habitat shift of cheer pheasant (Catreus wallichii) under the projected climate change scenario (representative concentrations pathways, RCPs) viz RCP 4.5, RCP 6.0, and RCP 8.5 by 2050 and 2070. We reported an increment in climatically suitable habitats, shifting towards higher altitudes, reflecting that higher altitudes would be the more favorable/suitable habitat in changing climate conditions. The model predicted an area of habitat as very highly suitable (4.24 km2) followed by highly suitable (50.35 km2), moderately suitable (109.29 km2), low suitable (91.03 km2), and rarely suitable (88.89 km2) in the current scenario. Projected enhancement of suitable habitat was 88.36 km2 and 80.75 km2 under RCP 4.5 and RCP 6.0 and reduced (12.05 km2) in RCP 8.5 along with no change (approx. 2805.23 to 2810.60 km2) in RCP 4.5 and RCP 6.0, respectively by 2050. By 2070, the expanded suitable habitat was 93.52.36 km2, 163.01 km2, and 133.33 km2 with a reduction of 12.87 km2, 14.14 km2, and 10.01 km2 with no change of approx. 2799.69 km2, 2728.91 km2, and 2762.68 km2 in RCP 4.5, RCP 6.0, and RCP 8.5, respectively by 2070. Based on the analysis, we inferred that the species' climatically suitable habitat would disintegrate in the future climate change. Further, the mean diurnal temperature range was identified as a critical driver, followed by isothermally and precipitation which drove the species to shift towards suitable habitats, i.e., higher altitudes. This study helps policymakers formulate effective conservation plans for protecting Himalayan range-restricted bird species at the pace of climate change.
Tracking the spatio-temporal distribution and regional differences of carbon footprint in grid scale of China's construction industry
Authors: Guo Xiaomin , Chuai Xiaowei 
Published: September 2022

Abstract
China is undergoing rapidly urbanization process, enlarging the continuous optimization of infrastructure and increasing relevant construction activities sharply, releasing abundant carbon emissions (CEs) subsequently. Understanding the spatial-temporal patterns and changing characteristics is thus a fundamental prerequisite to assess and sustain energy saving and CEs reduction of construction industry (CI) level. Previous studies on carbon emission (CE) of CI however, are often limited to the quantitative level, provincial or local administrative unit scales, lacking relevant studies at the spatial raster resolution scale, due to data gaps. Here, using the energy consumption, social economic data and a series of remote sensing data from EU EDGAR, this study explored the spatial-temporal distribution and changing characteristics of CEs from CI in typical years of 2007, 2010, and 2012. This study found, from 2007 to 2010, then 2012, in addition to subtle differences, the direct, indirect, and total CEs of CI all showed an increasing trend overall. All provincial units except Tianjin and Guangdong, indirect CEs took up more than 50% of the total CEs, which can clearly indicate the “dominant low carbon, recessive high carbon” characteristics of CI. The direct, indirect, and total CEs of the CI in 2007, 2010, and 2012, all showed a positive spatial clustering. Specifically, hot spots were mainly distributed in Beijing-Tianjin-Hebei, Yangtze River Delta, and cold spots were mainly focused in the west and northeast of China, presenting a similar distribution pattern with population-economy characteristics.
Dynamics of a nonlinear vibration reduction system with time delay feedback control
Authors: Mao Xiaochen , Ding Weijie 
Published: September 2022

Abstract
This paper reveals the dynamical properties of a nonlinear vibration reduction system with time delay feedback control and quasi-zero stiffness structure. The stable and unstable regions of the trivial solution of the system in the parameter plane of time delay and feedback gain are given. The amplitude-frequency responses and force transmissibility of the system under harmonic excitation are determined. The optimized parameters are obtained by using genetic algorithm. The complicated oscillations are explored, such as chaotic motions and multi-periodic orbits. Afterwards, the displacement and the energy of the primary structure and the force transmitted to the base are discussed under the shock excitation and random excitation respectively. The influences of time delay on the dynamical behaviors and reduction performance are shown.
Spin-dependent resonant Andreev tunneling in hybrid ferromagnetic metal - magnetic quantum dot - superconductor nanostructures
Authors: Koshina Elena , Krivoruchko Vladimir N. 
Published: September 2022

Abstract
There exists a variety of theoretical proposals to transform states induced by magnetic nanoparticles inside a superconducting gap into Majorana fermion states. The main challenge in this route is a conclusive proof and undoubted distinguishing between topologically trivial subgap Andreev bound states and topologically nontrivial magnetically polarized Majorana bound states. This motivated us to investigate a nonequilibrium electrons tunneling through a ferromagnetic normal metal - magnetic quantum dot - s-wave superconductor (F-mQD-SC) nanostructure where the mQD’s discrete levels are spin splitted. By using the Keldysh Green’s function method, the expressions for a tunnel current and probability of the Andreev reflection (AR) versus energy are derived and studied. We find that the system’s resonant ARs conductance exhibits different kinds of peaks depending on a spin splitting of the mQD levels, the spin polarization magnitude of the F-lead current, the gate voltage, and an external magnetic field magnitude. The nanostructure’s conductance versus a bias voltage exhibits extra peaks which at some combination of its parameters can mimic ones expected for Majorana modes in a topological superconducting state. The distinguishing transport characteristics of a F-mQD-SC nanoscale structure being in non-topological state are discussed. We suggest the results obtained can provide helpful clarification for understanding recent experiments in superconductor - ferromagnet hybrid nanostructures with topologically protected excitations.
Real-world data in primary care: validation of diagnosis of atrial fibrillation in primary care electronic medical records and estimated prevalence
Authors: de Burgos-Lunar C , Cura-González I del , Cárdenas-Valladolid J , Gómez-Campelo P , Abánades-Herranz JC , de-Andrés A López , Sotos-Prieto M , Iriarte-Campo V , Salinero-Fort MA 
Published: September 2022

Abstract

Background:
Primary care electronic medical records contain clinical-administrative information on a high percentage of the population. Before this information can be used for epidemiological purposes, its quality must be verified.
This study aims to validate diagnoses of atrial fibrillation (AF) recorded in primary care electronic medical records and to estimate the prevalence of AF in the general adult population.
Methods:
We performed a cross-sectional validation study of all diagnoses of AF recorded in primary care electronic medical records in Madrid (Spain).
We also performed simple random sampling of diagnoses of AF (ICPC-2 code K78) registered by 55 physicians and random age- and sex-matched sampling of the records that included a diagnosis of AF. Electrocardiograms, echocardiograms, and hospital discharge or cardiology clinic reports were matched.
Sensitivity, specificity, positive and negative predictive values (PPV and NPV), and overall agreement were calculated using the kappa statistic (κ). The prevalence of AF in the community of Madrid was estimated considering the sensitivity and specificity obtained in the validation. All calculations were performed overall and by sex and age groups.
Results:
The degree of agreement was very high (κ = 0.952), with a sensitivity of 97.84%, specificity of 97.39%, PPV of 97.37%, and NPV of 97.85%.
The prevalence of AF in the population aged over 18 years was 2.41% (95%CI 2.39%-2.42% [2.25% in women and 2.58% in men]). This increased progressively with age, reaching 16.95% in those over 80 years of age (15.5% in women and 19.44% in men).
Conclusions:
The validation results obtained enable diagnosis of AF recorded in primary care to be used as a tool for epidemiological studies.
A high prevalence of AF was found, especially in older patients.
The Blockchain Revolution and the Volatility of Stock market in Iran During the COVID-19 Crisis
Authors: Masoomzadeh Sara , haghighat jafar , Salmani Behzad 
Published: September 2022

Abstract
Determining the factors affecting the volatilityand risk of the stock market by expanding the pricing models of capital assets has been the focus of researchers. One of the variables that have a close relationship with financial markets is blockchain technology. Blockchain is a new technology in the field of secure computing. This technology can revolutionize the digital world and by using the features of distributed ledger for every online transaction, it can execute transactions in such a way that the assets can be identified in the future without endangering the privacy, and security of the assets and the involved parties in the transaction. Therefore, the present study investigated the effect of blockchain technology on total and systematic risk volatility in 84 selected companies in the stock market of Iran from April 2011 to August 2021 using the System Generalized Method of Moments (System GMM). The results of the study show that market share, blockchain technology, research and development, and COVID-19 have a negative effect on systematic risk, manufacturing companies have a positive effect on systematic risk, also market share, research and development, and COVID-19 have a negative effect on total risk, and blockchain technology and manufacturing companies have a positive effect on the total market risk.
Association Between RBC Folate and Trichomonas Vaginalis Infection among Women
Authors: Liao Wan-Zhe , Zhou Zhi-Yi , Mao Jun-Hao , Wang Zi-Xun , Hu Yi-Ming , Lou Yong-Fu , Zheng Qiao-Rui , Guo Xu-Guang 
Published: September 2022

Abstract
Background
Increased folic acid has been found to be latently protective against gynecological infection, including several kinds of vaginosis. In this study, we laid the emphasis on whether red blood cell (RBC) folate status was associated with the infectious ratio of Trichomonas vaginalis, a kind of anaerobic parasitic protozoan.
Methods
We set RBC folate as the dependent variable and Trichomonas vaginalis as the targeted independent variable. Other subsidiary variables were regarded as confounding variables and potential modifiers that may work as a potential role. The cross-sectional study was conducted with two merged waves of the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2004, and a sample of 1274 eligible women (1212 negativeand 62 positivein Trichomonas vaginalis infection) was integrated for exploration. Multivariate regression analyses, subgroup analyses, and subsequent smooth curve fittings were conducted to estimate the relationship between RBC folate and Trichomonas vaginalis in a specific gender.
Results
In the results of multivariable logistic regression analyses, a negative association was observed between stratified RBC folate status and Trichomonas vaginalis infection with all confounders adjusted. Referencing the lowest RBC folate concentration quartile, the higher concentration quartiles reported a relatively lower infection ratio, while there was a weak correlation between total RBC folate concentration and T.v. infection. In subgroup analyses, this association did not differ among the stratified groups.
Conclusions
The cross-sectional study indicated a negative association between RBC folic acid and Trichomonas vaginalis infection.
NF-κB1 p50 Stabilizes HIF-1α Protein through Suppression of ATG7-dependent Autophagy
Authors: Huang Chuanshu , Zhu Junlan , Li Yang , Xu Jiheng , Chen Ruifan , Guo Mengxi , Qian Xiaohui , Li Tengda , Tian Zhongxian , jin Honglei 
Published: September 2022

Abstract
Although our previous studies revealed that NF-κB1 (p50) itself alone could initiates NF-κB transcription-independent cascades to impair protein degradation of GADD45α and C-Myc and promotes p53 protein translation upon arsenic exposure, the function and underlying mechanisms of p50 in the regulation of protein expression is much less studied because of its lacking of transactivation domain. We here discovered a novel function of p50 in its stabilization of hypoxia-inducible factor 1α (HIF-1α) protein under the condition of cells exposed to arsenic exposure. In p50 deficient (p50-/-) cells, the HIF-1α protein expression was impaired upon arsenic exposure, and such defect could be rescued by reconstitutional expression of p50. Mechanistic study revealed that the inhibition of autophagy-related gene 7 (ATG7)-dependent autophagy was in charge of p50-mediated HIF-1α protein stabilization following arsenic exposure. Moreover, p50 deletion promoted nucleolin (NCL) protein translation to enhance ATG7 mRNA transcription via directly binding transcription factor Sp1 mRNA and increase its stability. We further discovered that p50-mediated miR-494 upregulation gave rise to the inhibition of p50-mediated NCL translation by interacting with its 3’-UTR. These novel findings provide a great insight into the understanding of biomedical significance of p50 protein in arsenite-associated disease development and therapy.