bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-vitro Susceptibility Testing Methods for Ceftazidime-avibactam against
Carbapenem-resistant Enterobacterales: Comparison with Reference
Broth Microdilution Method
Authors: Sharma Bhawna , Sreenivasan Priya , Angrup Archana , Kaur Satinder , Rana Sudesh , Kundu Jyoti , Biswal Manisha , Ray Pallab 
Published: December 2022

Introduction:
β-lactam antibiotics, mainly cephalosporins, and carbapenems, have been
the mainstay of treatment for infections caused by Enterobacterales. However, their role in treating
clinical infections has become limited because of the increase in resistance. There is a need to have
cost-effective and rapid methods for antimicrobial susceptibility testing methods for newer antibiotics
like ceftazidime-avibactam against carbapenem-resistant Enterobacterales (CRE), which can
be applied in routine clinical microbiology laboratories. With this aim, the present study was conducted
to compare the disk diffusion and gradient diffusion, i.e., the E-test method with the reference
broth microdilution (BMD) method for in-vitro testing of ceftazidime-avibactam against
CRE.

Material and Methods:
A total of 111 CRE isolates from various clinical samples were included.
Conventional PCR (Polymerase Chain Reaction) was done for the detection of genes encoding
carbapenemases and to see their expression, modified carbapenem inactivation method (mCIM)
along with EDTA (Ethylenediaminetetraacetic acid) carbapenem inactivation method (eCIM) was
done.

Results:
42.3% (47/111) isolates were resistant to ceftazidime-avibactam by the standard broth microdilution
method; however, 45.9% (51/111) were resistant by both disk diffusion and E-test. In
5.4% of isolates (similar in both methods), microbroth dilution method results did not match with
E-strip and disk diffusion. Very major errors (VME) by both disk diffusion and E-test were found
in 2.1% (1/47), and major errors (ME) were found in 7.8% (5/64) isolates (similar isolates in both
methods). The overall categorical agreement (CA) rate was 94.6% for both E-test and disk diffusion,
and the essential agreement (EA) rate was 90.1% (100/111) for E-test. 98% (109/111) of CRE
harbored carbapenemase genes either singly (30.3%) or in combination with others (69.7%).

Conclusion:
In conclusion, for CRE, E-test and the disk diffusion method for ceftazidimeavibactam
depicted an acceptable performance as an alternative to the reference broth microdilution
method.
Hyponatremia Related to Neurocritical Care: Focus on Diagnosis and
Therapy: A Systematic Review
Authors: Mezzini Gianluca , Marasco Stefano , Bertuccio Alessandro , Savioli Gabriele , Piccolella Fabio , Racca Fabrizio , Barbanera Andrea , Vitali Matteo 
Published: December 2022

Introduction:
Hyponatremia is the most frequently occurring electrolyte disorder in
neurocritical care and traumatic brain injury, aneurysmal subarachnoid hemorrhage (SAH),
neurosurgery, and ischemic stroke are the clinical conditions more often associated with this
condition. SIADH and CSWS are the main causes of hyponatremia in neurologically ill patients.
Since hyponatremia is a negative prognostic factor for neurocritical patients, early diagnosis and
consequent targeted therapy are of fundamental importance. The present review was carried out
to provide a brief recap on the main causes and management of hyponatremia in the neurocritical
patient.

Methods:
A methodical search of the medical literature using the online database MEDLINE was
carried out and studies comprising case reports, prospective and retrospective observational
studies, or randomized controlled clinical trials in which there is a diagnosis of hyponatremia in
neurocritical patients were included.

Results:
18 articles were analyzed, consisting of 8 case reports, 4 case series, 3 prospective trials,
1 retrospective study, and 1 multicenter trial. A total of 1371 patients from 18 studies were
included. Patients’ average age was 29.28 ± 20.9, respectively. TBI was the main cause of
hyponatremia in the literature reviewed; 12 studies were about the relationship between TBI and
hyponatremia, 2 studies about stroke, 2 studies about SAH and 1 about hyponatremia postneurosurgical
procedure.

Discussion:
Hyponatremia is the most common electrolyte disorder in hospitalized patients and
the main scenarios of hyponatremic neurocritical patients are subarachnoid hemorrhage, ischemic
stroke, traumatic brain injury and iatrogenic hyponatremia due to neurosurgical cases.

Conclusion:
Hyponatremia is a frequent finding in neurocritical care and is also a recognized
negative prognostic factor leading to increased mortality and ICU length hospitalization. Its
diagnosis and therapy are essential for correct neurocritical management. The most common
cause of serum sodium abnormality is SIADH, and an early diagnosis for target treatment is
paramount to prevent delayed symptoms and complications.
Weighted Gene Co-Expression Network Analysis of Immune Infiltration in
Nonalcoholic Fatty Liver Disease
Authors: Jia Jue , Yuan Guoyue , Wang Zhaoxiang , Xia Yue , Pan Yi , Zhang Li , Tang Fengyan , Yu Xiawen , Yang Zhongming , Wang Dong , Yang Ling 
Published: December 2022

Background:
Immune cell infiltration is an important component of nonalcoholic fatty
liver disease (NAFLD) pathogenesis. This study aimed to explore novel genes associated with immune
infiltration in the progression of NAFLD.

Methods:
CIBERSORT was used to evaluate the abundance of immune infiltration in the human
NAFLD via a high-throughput sequencing dataset. Further weighted gene co-expression network
analysis (WGCNA) was performed to search for the susceptibility gene module and hub genes
associated with differential immune cells. The expression of hub genes in different liver non-parenchymal
cell clusters and NAFLD-associated hepatocellular carcinoma (HCC) was also explored.

Results:
Four hub genes (ITGBL1, SPINT1, COL1A2, and THBS2) were ultimately identified,
which may be associated with immune infiltration, fibrosis progression, and activity score. The
receiver operating characteristic curve (ROC) analysis suggested that these genes had good predictive
value for NASH and advanced fibrosis. A single-cell analysis showed that COL1A2 was highly
expressed in hepatic stellate cells (HSCs), especially in the later stage, while SPINT1 was highly
expressed in cholangiocytes (Cho). In addition, ITGBL1, COL1A2, and THBS2 might be associated
with transforming from nonalcoholic steatohepatitis (NASH) to HCC. Our findings identified
several novel genes that might be related to immune infiltration in NAFLD.

Conclusion:
These genes may serve as potential markers for the assessment of immune infiltration
as well as therapeutic targets for NAFLD. More studies are needed to elucidate the biological mechanism
of these genes in the occurrence and development of NAFLD.
Correlation between Medications Used During Covid Infection and Post-Conditions after the Acute Phase of Infection: A Cross-Sectional Study
Authors: Naseef Hani , AbuKhalil Abdallah  Damin , Orabi Tala , Joza Mohammad , Mashaala Carmen , Elsheik Malak , Dababat Aseel , Qattosa Maram , Al-Shami Ni'Meh , Rabba Abdullah K 
Published: December 2022

Background
During the COVID-19 pandemic, off-label medication prescribing and utilizing herbal products and multiple vitamins in the treatment, prevention, and symptom management of COVID-19 was an urgently needed practice to halt the SARS-Cov2 infection crisis and progression.

Objectives
This study aimed to determine the correlation between medications used during the pandemic and SARS-CoV-2 infection post-recovery symptoms.

Methods
A cross-sectional questionnaire-based study was conducted on recovered COVID-19 patients. There were 20 multiple-choice questions, including patient demographics, treatment, and post-recovery symptoms. Chi-square and Fisher’s exact tests were used to investigate significant relationships. In addition, Binary logistic regression was performed to determine confounders. Data were analyzed using SPSS version 22.

Results
Medications and supplements varied in their therapeutic effects on SARS-CoV-2 post-recovery symptoms. Patients who took vitamin D and calcium experienced increased symptom frequency, and patients taking ACE inhibitors experienced more headaches and coughs. Furthermore, more patients receiving azithromycin were asymptomatic after recovery. Patients who took H2 antagonists reported persistent headaches and muscle pain.

Conclusion
Patients infected with SARS-CoV-2 have responded differently to medications, multivitamins, and herbal supplements. Patients reported resolution of some symptoms and persistence of others post-recovery. Therefore, expert opinion should be considered in covid-19 management until randomized controlled trials answer many questions and determine medications' safety and efficacy in prevention, treatment strategies, and symptoms of SARS-Cov-2 Infection post-recovery.
Prediction of Household Food Security Status using Ensemble Learning Models
Authors: Nigus Mersha , H.L. Shashirekha 
Published: December 2022

Background:This research uses the Ethiopian HICE survey dataset. Predicting food insecurity is critical in presenting the household's situation to the appropriate agencies that take preventative and intervention measures.Objective:This research paper's primary goal is to predict households' food security status using ensemble learning models.Methods:We use five base classifiers and a voting strategy for ensemble classification to enhance the performance of different base classifiers. Backward feature elimination and hard and soft voting-based ensemble learning are used to evaluate household food security. The training set for the basic classifiers is composed of the features that have been selected. Each ML classifier makes its prediction about the class label with the help of an ensemble learning method. For making decisions, hard voting uses a simple majority, whereas soft vote employs a weighted probability. To determine the final prediction. Ethiopian household income, consumption, and expenditure dataset are used to test the proposed ensemble learning approach. The backward feature elimination approach improved the model's performance by removing irrelevant and redundant features. Random forest, gradient boosting, multi-layer perceptron, K-nearest Neighbor, and Extra Tree classifiers were used to predict the family's level of food security. Finally, the authors compare the accuracy of ensemble and base classifiers.Result:The experiment result shows that the RF classifier surpasses the other base and ensemble classifiers and scored 99.98% accuracy. Because a Random forest classifier is an ensemble learning classifier that uses several decision trees, the final prediction is computed based on the majority vote of the several trees. The comparison result of hard and soft voting reveals that soft voting outperforms hard voting before and after feature selection with accuracies of 99.79% and 99.77%, respectively.Conclusion:Based on the result obtained, ensemble learning plays a significant role in predicting household food security status and implementing hard and soft voting. The RF classifier surpasses the other base and ensemble classifiers with an accuracy of 99.98%. From ensemble methods, soft voting surpasses hard voting with an accuracy score of 99.79%.
Characterization of Phenolic Compounds of Olea europaea L. and
Ceratonia siliqua L. Leaf Extracts by HPLC-ESI-MS
Authors: Meziani Saida , Oomah B. Dave , Bertrand Cédric 
Published: December 2022

Background:
Olive (Olea europaea L.) and carob (Ceratonia siliqua L.), which contain considerable amounts of phenolic compounds, are the most important
nutritional and therapeutic plants in the Mediterranean basin.

Objectives:
The goal of this work is to revalue carob and olive leaves as key sources of polyphenols, hence increasing the value of waste goods.

Methods:
In this study, aqueous acetone or ethanol (80% v/v) extracts of olive (O. europaea L. cultivar aimel) and carob (C. siliqua L.) leaves from Algeria
were evaluated for phenolic content, and the extracts were characterized by reverse-phase high-performance liquid chromatography-electrospray
ionization mass spectrometry (HPLC-ESI-MS).

Discussion and Results:
The total phenolic content of olive and carob leaf extracts ranged from 5.6 to 23 mg GAE/g. The use of HPLC-ESI-MS to investigate phenolics
revealed that the extracts included a variety of phenolic compounds, including 23 compounds in olive leaf extracts and 17 compounds in carob leaf
extracts. In olive and carob, the major phenolic components are oleuropein and myricetin rhamnoside, respectively.

Conclusion:
According to our findings, olea europaea and Ceratonia siliqua appear to be rich suppliers of natural chemicals. These plants have a lot of
potential in terms of medications and functional foods.
Portrait of t Democracy Practice and the Identity (Ethnic) Politics Struggle in the Local Political Arena: A Sociology and History Review
Authors: Irwan Irwan , Zusmelia Zusmelia , Siska Felia 
Published: December 2022

The period of social, economic and political transition is closely related to the collapse of the Suharto regime and the reformtion. This condition is signed by various kinds of conflicts , starting in the national and local political arena. Political propaganda at that time occured when the country was still in the authoritarian and centralistic spirit of the Suharto government. In fact, local actors and national politics are moving the issue to take power. This study focuses on the analysis of Indonesia democratic struggles in the dynamics of identity politics, the practice of identity politics during the New Order era was given the space in carrying out the movements and compared to the reformation period in Riau Province and the process of strengthening identity politics in the local sphere in Riau Province. This study used literature study in analyzing with sociological and historical theory. The results of this study showed that identity politics in Riau Province during the New Order and Reformation eras was different. During the New Order era, identity politics had no space and local people were shifted or removed, while during the reformation period, identity politics was open and expanded the contents of local people to become leader so it emerges the conflicts and presenting cases at the local level. This study brings out the term symbolic power in the local democratic process and carries the value of the nationalism spirit in local communities
Appetite-inducing effect and safety evaluation of Habb-e-Hilteet in patients with Ḍu‘f al-Ishtihā (anorexia): An open prospective clinical trial
Authors: Anwar Noman , Ahmed Noor Zaheer , Begum Shahida , Ansari Athar Parvez , Viswanathan Ammu Jayanthi 
Published: December 2022

Objectives: Anorexia is one among the most prevalent conditions triggering malnutrition, drastic weight loss and serious health issues in people especially older adults. Habb-e-Hilteet is commonly prescribed Unani pharmacopoeial formulation for anorexia. However, no scientific data is available as to its safety and efficacy. The current study assessed the appetite-inducing effect and safety of Habb-e-Hilteet in Ḍu‘f al-Ishtihā (anorexia) patients.
Methods: An open prospective clinical trial was carried out in 95 clinically diagnosed anorexia patients of either gender (19-65 yrs old). The study was approved by Institutional ethic committee and conducted in accordance with the GCP guidelines. Habb-e-Hilteet, 1 pill (500mg) was administered orally in patients twice daily for 14 days. The safety of the formulation was assessed by important pathological and biochemical indices and monitoring adverse events. The efficacy was assessed on the basis of improvement in the Simplified Nutritional Appetite Questionnaire (SNAQ) score.
Results: Out of 95 patients recruited, 78 completed the trial and 17 patients lost to follow-up. The mean age of patients was 29.8 yrs, with the majority (59.0%) being female. Overall therapeutic response was found to be 96%. A significant (P<0.05) increase in the mean SNAQ score was observed after 7 and 14 days of treatment when compared to baseline. No significant difference before and after treatment was observed in pathological and biochemical indices. No adverse events were reported during the entire study period.
Conclusion: The study results indicate that Habb-e-Hilteet could be a viable treatment option for anorexia with no safety concerns.
Keywords: Ḍu‘f al-Ishtihā; Buṭlān al-Shahwa; Anorexia; Habb-e-Hilteet; Unani pharmacopoeal formulation.
Memanusiakan Komunitas Anak Punk Melalui Pendampingan Dan Pemberdayaan di Kelurahan Labuh Baru Barat Kota Pekanbaru
Authors: Miftahuddin Miftahuddin , Suhaimi Suhaimi , Darmawati Darmawati , Saleh Habibis , Zatrahadi M Fahli 
Published: December 2022

Anak Punk di Pekanbaru muncul dari beberapa kelas sosial di masyarakat. mulai kelas bawah sampai yang hanya sebagai gaya, anak punk yang berada di Pekanbaruanak-anak jalanan yang hidup dipinggir jalan, tidur di trotoar, nongkrong di pom bensin. Kerjaan sehari-hari mereka biasanya mengamen, jualan koran, atau aktivitas lain yang bisa menghasilkan uang recehan disetiap persimpangan traffic light biasanya mereka terlihat di depan Mall SKA Pekanbaru Riau. Mereka (anak punk-red) yang di kelas sosial ini adalah orang yang sangat miskin hidupnya. Peserta kegiatan program pendampingan terdiri atas 10 orang anak punk yang mengikuti 3 bentuk kegiatan. Peserta dikumpulkan melalui kerjasama antara kepolisian dengan tim pengabdian di sektor tempat kegiatan dilakukan yakni di tanah masyarakat di daerah Kelurahan Labuh Baru Barat Kecamatan Payung Sekaki. Dari hasil kegiatan pendampingan kepada anak punk dapat diantaranya Tim pengabdian memberikan penyuluhan dan pelatihan tentang pembuatan kompos dan manfaat kompos bagi tanaman. Tim juga memperkenalkan juga komoditas tanaman yang di pilih ialah sawi, bayam dan jagung yang menjadi dasar pemilihan ini dikarenakan kemudahan dalam menanam dan cepat dalam hasil produksi panen sehingga tidak membutuhkan waktu yang lama dalam pembelajaran dan praktek, serta memberikan pelatihan pembuatan pupuk kompos kepada komunitas anak punk. Berikutnya Tim pengabdian dan pemberdayaan mengambil sampel kripik bayam dari hasil tanam yang akan menjadi nilai ekonomis yang lebih tinggi dari bahan mentah bayam yang bisa layu. hasil pelatihan literasi media dalam hal ini pembuatan blog, anak punk memiliki kesulitan yakni sebagian anak punk tidak memiliki e-mail dan kesulitan dalam mengoperasikan media komputer, namun ada juga yang mampu mengikuti karena sudah mampu mengoperasikan komputer namun belum maksimal karena hasil akhir belum tercapai.
Sistem Keamanan Kendaraan untuk Meningkatkan Skilled Individual dalam Menciptakan Peluang Usaha Baru di Provinsi Banten
Authors: Herdiani Aulia , Andayani Endang Sri , Awaluddin Muhammad 
Published: December 2022

Kasus pencurian kendaraan terutama di kota besar cenderung cukup tinggi. Pemberdayaan masyarakat dengan keahlian khusus dalam menciptakan system keamanaan butuh untuk dilakukan. Kegiatan pelatihan dalam pembuatan system keamanan ini ditekankan pada tiga hal utama, yaitu menciptakan system keamanaan kendaraan yang belum pernah digunakan oleh masyarakat secara luas. Sistem inovasi direncanakan menggunakan sistem yang dapat mensensor adanya panas akibat pembakaran mesin yang tidak diinginkan sehingga dapat memutus aliran listrik pada busi. Sensor panas menggunakan thermocouple yang di atur menggunakan microcontroller arduino serta sensor suhu DHT 11 yang terkoneksi dengan Electronic Control Unit (ECU). Pengujian dilakukan pada rentang suhu 35-50 oC. Hasil yang diperoleh adalah dikembangkannya sistem keamanan baru dengan sistem pengaturan thermal untuk mencegah adanya pencurian kendaraan dan untuk menciptakan peluang usaha baru bagi masyarakat setempat.
Pengembangan Model Hilirisasi Produk Berbasis Aren dan Berwawasan Lingkungan Pada Masyarakat Nagari Andaleh Baruh Bukik Kabupaten Tanah Datar
Authors: Azhar Zul , Aimon Hasdi , Putra Hari Setia , Jon Efendi Rer Nat , Syamwil Syamwil , Ardi Zadrian , Farida Anni 
Published: December 2022

Nagari Andaleh Baruh Bukik Kecamatan Sungayang di Kabupaten Tanah Datar terkenal dengan produk unggulan daerahnya penghasil gula aren. Tanaman pohon aren hampir merata setiap rumah tangga memiliki pohon aren dengan rata-rata 4-6 batang pohon. Masalahnya masyarakat belum mengetahui manfaat dan kegunaan aren. Terbukti bahwa hasil pohon aren yang diambil masyarakat hanya nira untuk gula aren dan buah untuk kolang kaling, sedangkan hilirisasi produk berbasis aren sangat banyak yang belum dimanfaatkan masyarakat secara ekonomi, kimia dan teknik. Nilai keekonomian pohon aren memiliki multi produk dan multi fungsi. Multi produk hampir seluruh batang tubuh pohon Aren dapat bernilai guna (used value), sedangkan multi fungsi pohon Aren mengurangi banjir, longsor serta tanah tidak mudah kering (hydrologis function). Pengembangan usaha pendapatan masyarakat dan membantu pemerintahan nagari menjalankan perencanaan sesuai dengan RPJM Nagari yang dimiliki, ada 4 kelompok sasaran dari nagari binaan ini antara lain: (1) memberikan pengetahuan dan penyuluhan tentang manfaat dan kegunaan aren dari sudut pandang ekonomi sumberdaya alam dan kajian lingkungan dan perencanaan pembangunan berwawasan lingkungan, (2) keterampilan dan praktek membuat hilirisasi produk buah kolang kaling untuk berbagai jenis makanan dan minuman, (3) penyuluhan dan pengetahuan pembuatan pupuk kompos dari kulit kolang kaling untuk mengurangi kerusakan lingkungan, serta (4) penyuluhan pada para pelaku pengolah buah kolang kaling, penyadap nira, pembuat gula, ijuk dan sagu aren serta resiko kecelakaan dan keselamatan kerja.
DE L’INTERMÉDIAIRE DANS LA PHILOSOPHIE DE L’ESPACE : PRÉCARITÉ, CRÉATION, LIBERTÉ
Authors: MIHALI Ciprian 
Published: December 2022

The Intermediary in the Philosophy of Space: Precariousness, Creation, Freedom. The reflection proposed by this text is the result of a dialogue spread over several years between philosophers and geographers. The best common ground between each other – in the right middle of the road – is undoubtedly the concept of the intermediary, which describes, negatively or affirmatively, the future of our physical, social, conceptual spaces and which speaks to us about discontinuity, hybridization, flow, contiguity, but also vulnerability, counterpowers and freedom. We wanted to show that far from being a concept of the residual, the unassimilable, the incomprehensible or even the irrational, the intermediary is the place of hospitality, the open work of alternative creativity, resistance, or affirmation of those who, excluded from dominant discourses, claim a right to speak and freely participate in social life.
Design of Novel Multiband Radar Absorbers Using Cylindrical Frequency Selective Surfaces
Authors: Fakhte Saeed 
Published: December 2022

Abstract
In this paper, a novel ultra-thin and multi-band radar absorber structure using cylindrical frequency selective surfaces (FSS) is proposed. The unit cell of the structure consists of a curved square ring printed on a cylindrical dielectric spacer to realize strong resonance to achieve efficient absorption of the incident microwave energy. The use of novel cylindrical FSS coating results in a considerable decrease of the radar cross section of a perfect electric cylinder. Furthermore, our studies prove that the proposed absorbing structure can be easily scaled to desired frequencies, and extension to dual- and multiband performances is possible. Meanwhile, the operational principle of the proposed absorbers is briefly introduced.