bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated cardiac troponin I and short-term mortality in patients with acute type A aortic dissection
Authors: Liu Shuai , Song Chenxi , Bian Xiaohui , Wang Hao , Fu Rui , Zhang Rui , Yuan Sheng , Dou Kefei 
Published: July 2022

Abstract

Aims
To explore the association between elevated cardiac troponin I (cTnI) on 30-day mortality in patients with acute type A aortic dissection (ATAAD).

Methods and results
A total of 1321 consecutive patients who were admitted to the emergency department of Fuwai Hospital from January 2016 to December 2020 were enrolled. Patients had computed tomography-confirmed ATAAD and were measured serum cTnI on admission. Patients were divided into the troponin-positive (cTnI &gt; 0.02 ng/mL) or the troponin-negative group (cTnI ≤ 0.02 ng/mL). Troponin was detected by PATHFAST instrument produced by Medins Co., Ltd., and the reference range of normal value is 0–0.02 ng/mL. A total of 522 out of 1321 patients (39.5%) in our study had elevated cTnI, who had higher 30–day mortality rate compared with the troponin-negative group (44.4% vs. 19.4% P &lt; 0.0001). Multivariate logistic regression results showed that elevated cTnI was an independent risk indicator for 30-day mortality (odds ratio: 2.582; 95% confidence interval: 1.357–4.914; P = 0.0039). The addition of elevated cTnI level to a clinical-based risk prediction model resulted in significant incremental prognostic value (AUC difference: 0.0261).

Conclusion
Elevated cTnI is common in patients with ATAAD, and is associated with increased 30-day mortality risk.
Multi-frequency magnetic resonance elastography of the pancreas: measurement reproducibility and variance among healthy volunteers
Authors: Shi Si-Ya , Wang Liqin , Peng Zhenpeng , Wang Yangdi , Lin Zhi , Hu Xuefang , Yuan Jiaxin , Huang Li , Feng Shi-Ting , Luo Yanji 
Published: July 2022

Abstract

Background
Patients with chronic pancreatitis often have irreversible pancreatic insufficiency before a clinical diagnosis. Pancreatic cancer is a fatal malignant tumor in the advanced stages. Patients having high risk of pancreatic diseases must be screened early to obtain better outcomes using new imaging modalities. Therefore, this study aimed to investigate the reproducibility of tomoelastography measurements for assessing pancreatic stiffness and fluidity and the variance among healthy volunteers.

Methods
Forty-seven healthy volunteers were prospectively enrolled and underwent two tomoelastography examinations at a mean interval of 7 days. Two radiologists blindly and independently measured the pancreatic stiffness and fluidity at the first examination to determine the reproducibility between readers. One radiologist measured the adjacent pancreatic slice at the first examination to determine the reproducibility among slices and measured the pancreas at the second examination to determine short-term repeatability. The stiffness and fluidity of the pancreatic head, body, and tail were compared to determine anatomical differences. The pancreatic stiffness and fluidity were compared based on sex, age, and body mass index (BMI).

Results
Bland–Altman analyses (all P &gt; 0.05) and intraclass correlation coefficients (all &gt;0.9) indicated near perfect reproducibility among readers, slices, and examinations at short intervals. Neither stiffness (P = 0.477) nor fluidity (P = 0.368) differed among the pancreatic anatomical regions. The mean pancreatic stiffness was 1.45 ± 0.09 m/s; the mean pancreatic fluidity was 0.83 ± 0.06 rad. Stiffness and fluidity did not differ by sex, age, or BMI.

Conclusion
Tomoelastography is a promising and reproducible tool for assessing pancreatic stiffness and fluidity in healthy volunteers.
Integrating CFIR-ERIC and e-Delphi Methods to Increase Telegeriatrics Uptake
Authors: Kernan Laura M , Dryden Eileen M , Nearing Kathryn , Kennedy Meaghan A , Hung Will , Moo Lauren , Pimentel Camilla B 
Published: July 2022

AbstractBackground and ObjectivesParticipatory implementation methods are needed in geriatric health care to improve care and services for a growing population of older adults. We describe an efficient participatory approach to improve uptake of Geriatric Research Education and Clinical Center (GRECC) Connect, a national geriatrics outpatient consultation service using telehealth technology to connect geriatric specialists to rural, older veterans though community-based clinics.Research Design and MethodsWe designed a three-phase participatory method to identify high-priority implementation strategies to support the uptake of GRECC Connect. We used the Consolidated Framework for Implementation Research-Expert Recommendations for Implementing Change (CFIR-ERIC) Strategy Matching Tool to derive expert-recommended implementation strategies informed by qualitative interviews with both GRECC Connect staff and clinicians at community-based clinics. We engaged expert panelists in a participatory two-step modified e-Delphi process using confidential surveys and discussion to prioritize strategies nationally.ResultsQualitative interviews revealed barriers, facilitators, and recommendations for program uptake. Many strategies recommended by CFIR-ERIC addressed multiple barriers but needed to be tailored to our specific context. In our two-step e-Delphi process, expert panelists shared previous experience with the strategies presented, views on the importance and feasibility of each, and arrived at a consensus about which strategies to prioritize nationally.Discussion and ImplicationsWe demonstrate the feasibility and benefits of engaging subject matter experts to identify strategies to be tested on a national level. Future considerations include weighting of survey responses, accounting for regional differences, and sensitivity of Likert scales used in the e-Delphi process.
The Determination Method of Total Polyphenol in Tea and Substitute Tea Based on [Ag(HIO6)2]5−–Luminol Chemiluminescence System
Authors: Su Fang , Yang Hui , Ma Tian , Chen Meifang , Liu Shipeng , Ma Li 
Published: July 2022

Abstract

Background
Scientific, accurate, and rapid detection of the composition and content of tea polyphenols is an important basis for their rational use and giving full play to their physiological effect. The spectrophotometric assays for total polyphenols have poor selectivity. Therefore, there is a need to develop a simple and reliable method for the determination of the total polyphenolic level in tea products.

Objective
The aim of this research was to develop a flow injection chemiluminescence (FI-CL) method based on the Ag(III)-luminol system for the total polyphenol content analysis of tea and substitute tea.

Method
Through Box–Behnken experimental design, we selected the optimum determination condition. The Ag(III) concentration was 5 × 10–5 mol/L, and the luminol concentration was 3 × 10–7 mol/L (including 0.15 mol/L NaOH). The peristaltic pump is 25 r/min, and the photomultiplier voltage is 600 v. Sample extracts were diluted 100 000 times for the FI-CL assay.

Results
Under optimal conditions, CL intensities were proportional to total polyphenol content (in terms of gallic acid concentrations) in the range of 0.1∼100 μg/L. The LOD and LOQ were 0.03 μg/L and 0.1 μg/L. The recovery values were in the range of 86.3–111.0% with a RSD of 1.04∼2.62%. The polyphenolic content of 12 teas and 6 substitute teas was determined, and the results of the developed method and Folin–Ciocalteu method were highly correlated (r = 0.9493 for tea and r = 0.8533 for substitute tea).

Conclusions
The proposed method is better than the Folin–Ciocalteu method in terms of selectivity, sensitivity, and accuracy. It is suitable for the determination of polyphenol content not only in tea, but also in substitute tea.

Highlights
We developed a new flow-injection analysis method for polyphenolic content determination based on the Ag(III)-luminol chemiluminescence system. It is simple, rapid, sensitive, and accurate. It is suitable for the determination of polyphenols content not only in tea, but also in substitute tea.
Seismic prediction and evaluation techniques for hot dry rock exploration and development
Authors: Fu Guoqiang , Peng Suping , Wang Ruizhen , Zhao Jingtao , Yan Feng , Xie Jingyu , Yang Yi , Xie Xinglong , Ming Yuanyuan , Wang Dan , Geng Jialu , Qi Wangning 
Published: July 2022

Abstract
Hot dry rock is generally buried deep within the subsurface and exhibits high temperatures, hardness and density, with low porosity and a lack of permeable fluids. It is thus difficult to investigate and poses a high exploration risk. This paper emphasizes the role of seismic exploration in evaluating hot dry rock exploration by exploiting technical advantages, including strong penetration, high resolution and precise depth determination. Denoising and weak deep effective signal processing, unique processing methods (e.g. high-precision static correction, pre-stack noise attenuation, wide-angle reflection in weak signal areas and fine velocity analysis) are used for high-quality imaging of formations inside the hot dry rock geothermal reservoirs to address the difficulties of data static correction. The joint inversion/data fusion of seismic and other geophysical methods allow the realization of non-linear quantitative prediction and evaluation of hot dry rock reservoirs. The geothermal reservoir parameters, including lithology, physical properties and temperature, are predicted by integrating various geophysical attributes. Further, the development potential of the geothermal reservoir is accurately evaluated, and promising results achieved.
Emotional Cues and Violent Behavior: Unexpected Basketball Losses Increase Incidents of Family Violence
Authors: Cardazzi Alexander , McCannon Bryan C , Humphreys Brad R , Rodriguez Zachary 
Published: July 2022

Abstract
Domestic violence generates long-term effects on offenders, victims, and other household members. While coercive behavior explains some family violence, aggression can also be reactive, triggered by emotional stimulus. Insight into triggers of family violence can inform policy and mitigate abusive behavior. Card, D. and G. B. Dahl. (2011). “Family Violence and Football: The Effect of Unexpected Emotional Cues on Violent Behavior,” 126 The Quarterly Journal of Economics 103–43 undertook a novel analysis of family violence triggers using unexpected losses by American professional football teams. We extend research on this trigger using data from National Basketball Association (NBA) games. Our results show that unexpected NBA losses lead to increased in-home violence. Heterogeneity analyses show that these effects are larger for weekend games, when referees are fatigued, and closer to the playoff season. (JEL J44, K42, Z22).
Serosurvey for SARS-CoV-2 among blood donors in Wuhan, China from September to December 2019
Authors: Chang Le , Zhao Lei , Xiao Yan , Xu Tingting , Chen Lan , Cai Yan , Dong Xiaojing , Wang Conghui , Xiao Xia , Ren Lili , Wang Lunan 
Published: July 2022

Abstract
The emerging of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused COVID-19 pandemic. The first case of COVID-19 was reported at early December in 2019 in Wuhan city, China. To examine specific antibodies against SARS-CoV-2 in biological samples before December 2019 would give clues when the epidemic of SARS-CoV-2 might start to circulate in populations. We obtained all 88,517 plasmas from 76,844 blood donors in Wuhan between 1st September and 31st December 2019. We first evaluated the pan-immunoglobin (pan-Ig) against SARS-CoV-2 in 43,850 samples from 32,484 blood donors with suitable sample quality and enough volume. 264 samples from 213 donors were pan-Ig reactive, then further tested IgG and IgM, and validated by neutralizing antibodies against SARS-CoV-2. 213 samples (from 175 donors) were only pan-Ig reactive, 8 (from 4 donors) were pan-Ig and IgG reactive and 43 (from 34 donors) were pan-Ig and IgM reactive. Microneutralization assay showed all negative results. In addition, 213 screened reactive donors were analyzed and didn’t show obviously temporal or regional tendency, but the distribution of age showed a difference compared with all tested donors. Then we reviewed SARS-CoV-2 antibody results from these donors who donated several times from September 2019 to June 2020, partly tested in a previous published study, no one was found a significant increase in S/CO of antibodies against SARS-CoV-2. Our findings showed no SARS-CoV-2 specific antibodies existing among blood donors in Wuhan, China before 2020, indicating no evidence of transmission of COVID-19 before December 2019 in Wuhan, China.
Immunology of a unique biological structure: the Echinococcus laminated layer
Authors: Díaz Álvaro , Barrios Anabella A , Grezzi Leticia , Mouhape Camila , Jenkins Stephen J , Allen Judith E , Casaravilla Cecilia 
Published: July 2022

Abstract
The larval stages of the cestode parasites belonging to the genus Echinococcus grow within internal organs of humans and a range of animal species. The resulting diseases, collectively termed echinococcoses, include major neglected tropical diseases of humans and livestock. Echinococcus larvae are outwardly protected by the laminated layer (LL), an acellular structure that is unique to this genus. The LL is based on a fibrillar meshwork made up of mucins, which are decorated by galactose-rich O-glycans. In addition, in the species cluster termed E. granulosus sensu lato, the LL features nano-deposits of the calcium salt of myo-inositol hexakisphosphate (InsP6). The main purpose of our article is to update the immunobiology of the LL. Major recent advances in this area are (i) the demonstration of LL “debris” at the infection site and draining lymph nodes, (ii) the characterization of the decoy activity of calcium InsP6 with respect to complement, (iii) the evidence that the LL mucin carbohydrates interact specifically with a lectin receptor expressed in Kupffer cells (Clec4F), and (iv) the characterization of what appear to be receptor-independent effects of LL particles on dendritic cells and macrophages. Much information is missing on the immunology of this intriguing structure: we discuss gaps in knowledge and propose possible avenues for research.
Neuronal guidance genes in health and diseases
Authors: Yuasa-Kawada Junichi , Kinoshita-Kawada Mariko , Tsuboi Yoshio , Wu Jane Y 
Published: July 2022

Abstract
Neurons migrate from their birthplaces to the destinations, and extending axons navigate to their synaptic targets by sensing various extracellular cues in spatiotemporally controlled manners. These evolutionally conserved guidance cues and their receptors regulate multiple aspects of neural development to establish the highly complex nervous system by mediating both short- and long-range cell-cell communications. Neuronal guidance genes (encoding cues, receptors or downstream signal transducers) are critical not only for development of the nervous system, but also for synaptic maintenance, remodeling and function in the adult brain. One emerging theme is the combinatorial and complementary functions of relatively limited classes of neuronal guidance genes in multiple processes, including neuronal migration, axonal guidance, synaptogenesis and circuit formation. Importantly, neuronal guidance genes also regulate cell migration and cell-cell communications outside the nervous system. We are just beginning to understand how cells integrate multiple guidance and adhesion signaling inputs to determine overall cellular/subcellular behavior and how aberrant guidance signaling in various cell types contributes to diverse human diseases, ranging from developmental, neuropsychiatric and neurodegenerative disorders to cancer metastasis. We review classic studies and recent advances in understanding signaling mechanisms of the guidance genes as well as their roles in human diseases. Furthermore, we discuss the remaining challenges and therapeutic potentials of modulating neuronal guidance pathways in neural repair.
Long-term follow-up of Janus-kinase inhibitor and novel active disease biomarker in juvenile dermatomyositis
Authors: Huang Baozhen , Wang Xinning , Niu Yanlin , Ding Yuchuan , Wang Xiaolei , Tan Qingqing , Li Yucong , Liu Yuan , Chi Ying , Wang Yuan , Zhou Zhixuan , Li Jianguo 
Published: July 2022

AbstractObjectiveTo evaluate the use of Janus kinase inhibitor (JAKi) in treating JDM and develop cytokine biomarkers of active disease.MethodsThis study involved a retrospective cohort study that evaluated JAKi in 101 JDM patients as well as a cross-sectional study of cytokines in 128 JDM patients and 30 controls between November 2017 and December 2021 in the Affiliated Children’s Hospital of Capital Institute of Pediatrics (China).ResultsDuring the median follow-up period of 19 months, 65.5% of the patients had improved rashes, and CAT-BM scores decreased. Overall, 39.6% of JDM patients eliminated glucocorticoids. Muscle strength was improved in all patients who had abnormal muscle strength before JAKi use. Patients and parents provided positive subjective reviews of JAKi, and no serious adverse events were reported. Potential side effects of JAKi included abnormal leukopoenia (14/95) and cough (16/83), which affected over 10% of the JDM patients. In the cytokine analysis, 12/34 cytokines were significantly elevated in active JDM patients. Compared with active JDM patients with multiple phenotypes, active JDM patients with only rashes demonstrated lower cytokine levels. Anti-NXP2-positive active patients had lower cytokine levels compared with those without positive anti-NXP2 antibodies. Among all increased cytokines, IL-1RA changed most dramatically, reaching over 793 times the mean of normal values. We developed a panel composed of six cytokines to differentiate active or stable status in our cohort (area under the curve = 0.8486, P &lt; 0.05).ConclusionThe preliminary evidence suggested that JAKi is a relatively safe and effective alternative for JDM patients. Cytokine profiles could well reflect the inflammatory status of JDM patients.
Mycetoma management and clinical outcomes: the Mycetoma Research Center experience
Authors: Musa Esraa Abdelgadir , Abdoon Iman Hassan , Bakhiet Sahar Mubarak , Osman Bashier , Abdalla Safa A , Fahal Ahmed Hassan 
Published: July 2022

Abstract

Background
Mycetoma is a chronic granulomatous inflammatory disease that affects the cutaneous and subcutaneous tissues, leading to gruesome complications if not treated early. As a neglected disease, it has received scant attention in developing curable drugs. Mycetoma treatment is still based on expert opinions in the absence of guidelines.

Methods
This descriptive, cross-sectional, hospital-based study aimed to determine and assess the disease treatment outcomes observed at Mycetoma Research Center, Sudan.

Results
In this study, 75% of patients had eumycetoma, all of whom were treated with itraconazole and 37.4% underwent surgical excision, while 25% of the patients had actinomycetoma, 99.2% of whom were treated with a combination of cotrimoxazole and amoxicillin-clavulanate. The cure rate was 12.7% and 14.3% for patients with eumycetoma and actinomycetoma, respectively. Only 6.1% of eumycetoma patients underwent amputation. Remarkably, no patient with actinomycetoma underwent an amputation. Small lesions (OR=10.09, p&lt;0.001) and good follow-up (OR=6.81, p=0.002) were positive predictors of complete cure. In terms of amputation, history of surgical recurrence at presentation (OR=3.67, p=0.020) and presence of grains (OR=7.13, p=0.012) were positive predictors, whereas small lesions were negative predictors (OR=0.06, p=0.009).

Conclusions
Treatment of mycetoma was suboptimal, with a low cure rate despite a long treatment duration. Complete cure has a significant association with small lesions and good follow-up.
Occupation and Semen Parameters in a Cohort of Fertile Men
Authors: Meyer John D. , Brazil Charlene , Redmon J. Bruce , Wang Christina , Sparks Amy E. , Swan Shanna H. 
Published: July 2022

Objective
We examined associations between occupation and semen parameters in demonstrably fertile men in the Study for Future Families.

Methods
Associations of occupation and workplace exposures with semen volume, sperm concentration, motility, and morphology were assessed using generalized linear modeling.

Results
Lower sperm concentration and motility were seen in installation, maintenance, and repair occupations. Higher exposure to lead, and to other toxicants, was seen in occupations with lower mean sperm concentrations (prevalence ratio for lead: 4.1; pesticides/insecticides: 1.6; solvents: 1.4). Working with lead for more than 3 months was associated with lower sperm concentration, as was lead exposure outside of work.

Conclusions
We found evidence in demonstrably fertile men for reduced sperm quality with lead, pesticide/herbicide, and solvent exposure. These results may identify occupations where protective measures against male reproductive toxicity might be warranted.
Exercise Preferences for a Workplace Wellness Program to Reduce Cardiovascular Risk and Increase Work Productivity
Authors: SantaBarbara Nicholas J. , Rezai Roxana , Soetenga Samantha , Terry Elisa , Carpenter Catherine L. , Comulada Warren Scott 
Published: July 2022

Objective
Workplace wellness programs can reduce cardiovascular risk and improve worker productivity; however, recruitment and adherence remain a challenge. Tailoring programs based on employee exercise preferences may address these concerns.

Methods
A total of 458 UCLA adult employees who responded to UCLA Bruin marketing e-mail completed a battery of questions regarding their exercise preferences (eg, preferred duration, intensity, type). Recruitment took place in June 2021.

Results
Participants prefer workplace wellness programs that (1) focus on improving multiple different aspects of physical health; (2) take place in a variety of locations; (3) were administered by a coach who is physically present; (4) occur 2–3 times per week for roughly 60 minutes each time; (5) include a range of intensities; and (6) consist of aerobic and weight training.

Conclusions
Future studies should use these results to design future workplace wellness programs.
Relationships Among Pay-for-Performance, Work Stressors, and Depression in Sales Workers
Authors: Amagasa Takashi , Nakayama Takeo 
Published: July 2022

Objective
The aim of this study was to examine whether pay-for-performance (PFP) affects depression via work stressors.

Methods
This study used data from self-administered questionnaires obtained from 1160 sales workers, and the data were analyzed using structural equation modeling (covariance structure analysis). Models included “long hour labor condition (LHLC),” which consisted of the number of working hours, hours worked per month, service overtime, and increase or decrease in working hours; seven work stressors; and the Center for Epidemiologic Studies Depression scale.

Results
According to the final model (CFI = 0.950, RMSEA = 0.035), PFP worsened LHLC (standardized total effect [STE] = 0.357) and improved job control (STE = 0.108), and although slightly, exacerbated depression via other work stressors (STE = 0.051).

Conclusions
Our results suggest the need for measures to avoid prolonged overwork to prevent worsening of employee mental health when introducing or implementing PFP.