bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toluene diisocyanate occupational exposure data in the polyurethane industry (2005–2020): A descriptive summary from an industrial hygiene perspective
Authors: Sayles Catherine , Finnegan Natalie , Pike Timothy , Spence Mark W 
Published: August 2022

This article provides an overview of toluene diisocyanate (TDI) workplace air concentration data. Data were collected between 2005-2020 in workplaces across the United States, Canada, and the European Union by a number of different organizations, primarily using the sampling procedures published in OSHA Methods 42 and 5002. The data were then collated and organized by the International Isocyanate Institute. Air samples were collected from several market segments, with a large portion of the data (87%) from the flexible foam industry. The air samples (2534 in total) were categorized into “area” or “personal,” and the personal samples were subcategorized into “task,” “short term,” and “long term.” Most of the air sample concentrations (87%) were less than 5 ppb. However, the presence of airborne TDI greater than 5 ppb indicated the importance of respiratory protection in some situations; therefore, respirator use patterns were studied and summarized. Additionally, this article provides a summary of air sample concentrations at different flexible foam manufacturing job roles. The information on air sampling concentrations and respiratory protection during TDI applications collected in this paper could be useful for product stewardship and industrial hygiene purposes in the industries studied.
The Effect of Perceived Organizational Support of Nurses on Their Resilience: A Cross-Sectional Study From Turkey
Authors: Karadas Ayse , Dogu Özlem , Oz Seda Degirmenci 
Published: August 2022

Background Throughout and following the ongoing Coronavirus outbreak, there is an urgent need to focus on organizational support strategies aimed at improving the resilience of nurses. Purpose This research aims to examine the relationship between the nurses’ perceived organizational support and their resilience levels, and to reveal the characteristics that make a significant difference. Methods The data of this descriptive and cross-sectional study were collected from 722 nurses in February 2021 using the web-based survey method. The study followed the STROBE guideline. The data collection tools included the Introductory Information Form, the Survey of Perceived Organizational Support, and the Psychological Resilience Scale. Results Nurses were concluded to have perceived a moderate level of organizational support and their psychological resilience were found to be higher than average. A positive relationship was determined between the organizational support perceived by nurses and their psychological resilience. The gender, position/title of nurses, their work experience in COVID-19 treatment services, and having been infected with the COVID-19 virus were found to affect their perception of organizational support and resilience. Conclusion Organizational support perceived by nurses significantly affects their resilience. Resilience programs should, in particular, prioritize permanent clinical nurses who are in the risk group in terms of resilience, female nurses, nurses who had been infected with the COVID 19 virus, and nurses who have been assigned to COVID-19 treatment wards.
Characterization and optimization analysis on surface finish and energy consumption in turning of Al-4032/GMP MMC produced by stir casting
Authors: Saini Pardeep , Singh Pradeep K 
Published: August 2022

Control of energy expenditure in computer numerical control (CNC) machining is needed for eco-friendly operation of machining operations. Production industries deeply emphasize the improvement of productivity and saving in cost. The aluminum-based metal matrix composites (AMCs) can be substituted for metals for their mechanical properties in several applications. However, to bring in composite to usage, generally demand certain machining operation, which is quite challenging. This paper presents fabrication, characterization, and machining (turning) of Al-4032/6%GMP (granite marble powder) composite. Optical micrographs (OM) and scanning electron microscopy (SEM) with energy dispersive x-ray analysis (EDAX) have been used for the portrayal of the composite microstructure, surface topography, and fracture behavior. Also, mechanical characterization (tensile strength, micro-hardness, and impact strength) of the fabricated AMC has been carried out. The AMC samples have been examined for machinability for CNC turning operation. Cutting speed, feed rate, and depth of cut are the cutting parameters selected for the machining experiments. The response surface methodology (RSM)-based desirability function has been used to obtain the best combination of parameters for achieving the desired objectives. Experimental results demonstrate the built-up edge (BUE) formation on cutting insert and interfacial bonding of particles on workpiece surface at low cutting speed. Generally, smooth cutting operation has been observed at cutting speeds above 100 m/min. Best surface finish (1.38 μm) and minimum energy consumption (0.27 kWh) have been observed at cutting speed 176 m/min, feed rate 0.15 mm/rev, and depth of cut 0.45 mm.
Severe acute radiation dermatitis after palbociclib therapy in the setting of palliative radiotherapy
Authors: Kim Kristine N , Salerno Michael , Shah Payal D , Matro Jennifer , LaRiviere Michael J 
Published: August 2022

Introduction Cyclin-dependent-kinase 4/6(CDK4/6) inhibitors are widely used as a first-line systemic treatment for patients with hormone receptor-positive, human epidermal growth factor receptor-2 negative metastatic breast cancer. Although many patients with metastatic breast cancer require palliative radiotherapy (RT), there are limited data on the safety of combining a CDK4/6 inhibitor with palliative RT. Case Report Presented is a case of acute high-grade radiation dermatitis with low-dose palliative RT following administration of palbociclib. A 49-year-old woman with newly diagnosed hormone receptor-positive invasive ductal carcinoma of the left breast presented with lytic bone lesions in the left femur and lumbar spine. The patient initiated treatment with goserelin, tamoxifen, and palbociclib. She underwent prophylactic surgical fixation of the left femur and received post-operative RT encompassing the entire surgical nail (30 Gy/10 fractions) and palliative RT to the lumbar spine for pain relief (20 Gy/5 fractions). During cycle 4, palbociclib was stopped 3 days prior to the start of RT to reduce the risk of toxicity risk. However, 16 days after starting RT, she developed painful erythematous papules and bullae with moist desquamation on the left groin and lumbar spine. Management & Outcome Her symptoms were managed with topical Aquaphor-lidocaine, silver sulfadiazine, and aluminum acetate soaks. Dermatitis subsided to dry desquamation within 2 weeks. The patient denied late toxicity at 11 months follow-up. Discussion Larger retrospective or prospective studies are needed to further elucidate the safety of combined CDK4/6 inhibitors and RT. In the meantime, special precautions are warranted in patients receiving combined therapy.
Symptom Profile Characterization Using the Beck Anxiety Inventory Among Undergraduates in the United States
Authors: Crosby Shae , Kwon Chloe , Rodney Tamar 
Published: August 2022

Background: The Beck Anxiety Inventory (BAI) is widely used to measure the severity of anxiety. This tool may additionally allow for an in-depth analysis of symptom typology, as reported symptoms can be placed into four categories (subjective, neurophysiologic, autonomic, and panic-related). Although overall severity ratings in populations may be similar, the type of symptoms reported as severe may differ dependent on characteristics of the populations assessed. Aims: This study examines the variety of anxiety symptoms manifested among U.S. university students and the impact of symptom typology on seeking treatment. Method: This was an online survey completed by undergraduate students in the United States, responding to questions including the BAI. Results: A multivariate logistic regression analysis model showed that the likelihood of students seeking treatment increased when they experienced more “subjective” anxiety symptoms, odds ratio (OR) = 2.443, 95% confidence interval (CI) = [1.462, 4.082], p = .001, as compared to symptoms in the other three categories. Students were also asked to report which symptoms were “most bothersome” to them. Many students reported difficulty sleeping and an inability to concentrate. These symptoms are not measured by the BAI. Conclusion: The results of this study show the potential for the BAI to be used as a symptom categorization tool to be considered independently in identifying target areas for treatment. An understanding of the existence of these gaps may allow providers to better identify students with anxiety who present with symptoms not included in the BAI.
Cognitive Disengagement Syndrome (Sluggish Cognitive Tempo) and Social Withdrawal: Advancing a Conceptual Model to Guide Future Research
Authors: Fredrick Joseph W. , Becker Stephen P. 
Published: August 2022

Objective: Cognitive disengagement syndrome (CDS, previously referred to as “sluggish cognitive tempo”) is a set of symptoms defined by excessive mind-wandering, mental confusion, and slowed behaviors separable from ADHD inattention. Method: Of the studies examining CDS in relation to psychosocial outcomes, one of the most established correlates of CDS is social withdrawal. However, studies have yet to test mechanisms or moderators of the link between CDS and social withdrawal. Results: As a parallel body of literature exists in developmental psychopathology on predictors and outcomes of social withdrawal, this review merges these literatures to identify themes and advance a conceptual model on mechanisms (e.g., task-unrelated thought, poorer social skills, social anxiety) and moderators (e.g., behavioral inhibition, sex, parenting) of the CDS and social withdrawal link. Conclusion: This model provides researchers and clinicians with testable hypotheses to better understand the link between CDS and social withdrawal and to identify treatment targets to improve the social engagement of youth with CDS.
Frequency and impact on clinical outcomes of sarcopenia in patients with idiopathic pulmonary fibrosis
Authors: Fujita Kohei , Ohkubo Hirotsugu , Nakano Akiko , Mori Yuta , Fukumitsu Kensuke , Fukuda Satoshi , Kanemitsu Yoshihiro , Uemura Takehiro , Tajiri Tomoko , Maeno Ken , Ito Yutaka , Oguri Tetsuya , Ozawa Yoshiyuki , Murase Takayuki , Niimi Akio 
Published: August 2022

Objectives Sarcopenia is a syndrome characterized by reduced muscle mass and function. It is well-recognized as a complication in chronic diseases such as chronic obstructive pulmonary disease. However, little is known about sarcopenia in patients with idiopathic pulmonary fibrosis (IPF). This study aimed to investigate the clinical characteristics of sarcopenia and the association between quality of life and sarcopenia in patients with IPF. Methods In this pilot cross-sectional study, 56 Japanese outpatients with IPF (49 men) were enrolled prospectively. Sarcopenia was diagnosed according to the criteria of the Asian Working Group for Sarcopenia 2019. Its associations with clinical parameters including age, pulmonary functions, physical performance, and patient-reported outcomes (PROs) were examined. Results The frequency of sarcopenia was 39.3% ( n = 22) in this cohort. There were significant differences in St George’s Respiratory Questionnaire ( p = .005), modified Medical Research Council score ( p = .004), and Hospital and Anxiety Depression Scale depression score ( p = .030) between the sarcopenic and non-sarcopenic groups. On multivariate regression analysis, 6-min walk distance (6MWD) was an independent factor associated with sarcopenia (odds ratio 1.241, 95% confidence interval 1.016–1.515, p = .034). Conclusion Sarcopenia was associated with PROs and physical performance in patients with IPF.
Total Arch Thoracic Endovascular Aortic Repair Using Double Fenestrated Physician-Modified Stent-Grafts: 100 Patients
Authors: Canaud Ludovic , Chassin-Trubert Lucien , Abouliatim Issam , Hireche Kheira , Bacri Christophe , Alric Pierre , Gandet Thomas 
Published: August 2022

Objective: The aim was to evaluate early and medium-term outcomes of double fenestrated physician-modified endovascular grafts for total endovascular aortic arch repair. Methods: This single-center retrospective analysis of prospectively-collected data included 100 patients, from January 2017 to December 2021, undergoing thoracic endovascular aortic repair (TEVAR) for zone 0. The fenestrations were a proximal larger fenestration that incorporated the brach2iocephalic trunk and left common carotid artery and a distal smaller fenestration for the left subclavian artery (LSA). Only the LSA fenestration was stented. Results: The median duration for stent-graft modification was 23±6 minutes. Of the 100 patients, 70 were men. The mean patient age was 70±10.5 years. Indications for treatment included degenerative aortic arch aneurysm (n=32), dissecting aortic arch aneurysm after type A dissections (n=23) and (n=19) after type B dissections, acute complicated type B dissection (n=16), and other pathologies (n=10). Technical success rate was 97%. The 30 day mortality was 2% (n=2). Four patients (4%) had minor stroke with full recovery. One patient (1%) had a type IA endoleak, 1 patient (1%) had a type IB endoleak, and 2 patients (2%) have a type II endoleak from the LSA. Eight patients (8%) required reintervention: 1 type IA endoleak, 1 type IB endoleak, 1 retrograde type A dissection, and 5 because of access-related complications. During a mean follow-up of 24±7.2 months, there were no aortic rupture, paraplegia, and all supra-aortic trunks were patent. Conclusions: Double homemade fenestrated TEVAR is both feasible and effective for total endovascular aortic arch repair avoiding the need for anatomical and extra-anatomical surgical revascularization. The long-term durability will need to be assessed in studies with long-term follow-up. Clinical Impact Double homemade fenestrated TEVAR is effective for total endovascular aortic arch repair avoiding the need for anatomical and extra-anatomical surgical revascularization. The standout feature of this double fenestrated device is its simple handling during operation with the proximal fenestrations being directed to the orifices of the BT and LCCA automatically when the LSA fenestration is catheterized and secured by covered stent placement. The deployment algorithm actively steers the operator away from superfluous manipulations of the device within the arch and avoids guidewire manipulation in carotid arteries. The long-term durability will need to be assessed in studies with long-term follow-up.
Dual anti-platelet therapy for secondary prevention in intracranial atherosclerotic disease: a network meta-analysis
Authors: Reale Giuseppe , Zauli Aurelia , La Torre Giuseppe , Mannocci Alice , Mazya Michael V. , Zedde Marialuisa , Giovannini Silvia , Moci Marco , Iacovelli Chiara , Caliandro Pietro 
Published: August 2022

Background: Intracranial arterial stenosis (ICAS) is a non-marginal cause of stroke/transient ischemic attacks (TIAs) and is associated with high stroke recurrence rate. Some studies have investigated the best secondary prevention ranging from antithrombotic therapy to endovascular treatment (ET). However, no direct comparison between all the possible treatments is currently available especially between single and dual anti-platelet therapies (SAPT and DAPT). Aim: To establish whether DAPT is more effective than SAPT in preventing the recurrence of ICAS-related stroke, by means of a network meta-analysis (NMA). Design: Systematic review and NMA in accordance to PRISMA guidelines. Data sources and methods: We performed a systematic review of trials investigating secondary prevention (SAPT or DAPT, anticoagulant treatment or ET) in patients with symptomatic ICAS available in MEDLINE, Scopus and Web of Science from January 1989 to May 2021. We defined our primary efficacy outcome as the recurrence of ischemic stroke/TIA. We analysed the extracted data with Bayesian NMA approach. Results: We identified 815 studies and included 5 trials in the NMA. Sequence generation was adequate in all the selected studies while the allocation concealment method was described in one study. All the included studies reported the pre-specified primary outcomes, and outcome assessment was blinded in all the studies. We used the fixed-effect approach as the heterogeneity was not significant ( p > 0.1) according to the Cochran’s Q statistic. DAPT was superior to SAPT and DAPT + ET in preventing stroke/TIA recurrence [respectively, odds ratio (OR), 0.59; confidence interval (CI), 0.39–0.9; and OR, 0.49, CI, 0.26–0.88], while no difference was found between DAPT and oral anticoagulant therapy (OAC). DAPT was safer than OAC (OR, 0.48; CI, 0.26–0.89) and DAPT + ET (OR, 0.50; CI, 0.35–0.71), while no difference was found between DAPT and SAPT. Conclusion: DAPT is more effective than SAPT for secondary stroke prevention in patients with symptomatic ICAS, without increasing the risk of haemorrhage. Registration: Prospero/CRD42019140033.
Novel Methods to Understand the Temporal Nature and Accuracy of Delivery for Insulin Infusion Pumps
Authors: Kumar S. Siddharth , Karia Deval , Gopkumar Arjun , Koty Pavan G. , Arora Manish 
Published: August 2022

Background: A wide suite of methods are available to evaluate delivery accuracy of insulin pumps. However, these methods do not capture any temporal information, which may be critical for design of artificial pancreas (AP) systems. We propose a novel video microscopy method to understand the delivery accuracy and temporal nature for a new durable pump under development (IFP), and a commercially available pump (Medtronic 722G, M722G). Methods: The cannula tip of an infusion set is inserted into a graduated pipette placed under a digital microscope. A video of the delivery is captured to track the fluid meniscus, to measure volumetric delivery rate and accuracy. This was done for a programmed value of 0.5 and 1 U. A similar procedure was adopted to track linear motion of the piston rod, which actuates the reservoir plunger, for a programmed value of 10 U. Results: It was observed that the commercially available pump delivers insulin in pulses of 0.05 U every two seconds. The mean absolute volumetric delivery error (MAE) for both pumps was found to be within the values reported previously. More importantly, it was found that a significant fraction of the programmed value is delivered, after completion of the planned bolus duration (IFP: 14.31% vs M722G: 9.38% for 1 U delivery). Conclusions: The methods presented in this article help understand the delivery dynamics of liquid drug delivery devices. Our results indicate that a significant fraction of insulin delivery happens after the planned bolus duration, which might be important consideration for design of AP systems.
Lean Design of the Pediatric Intensive Care Unit Patient Room for Efficient and Safe Care Delivery
Authors: Lu Yuqian , Bishop Naomi B. , Zadeh Rana 
Published: August 2022

Background: The pediatric intensive care unit (PICU) is an environment where seriously ill children receive complex care, delivered mostly by specialty-trained nurses (registered nurses [RNs]) who must perform multiple high-level tasks. With stressors on healthcare systems at an all-time high, design that optimizes RN workflow has taken on a renewed imperative. Objectives: To employ a multimodal approach (1) to identify environmental factors in the PICU patient room that contribute to caregiver workflow inefficiencies, (2) to optimize safety by identifying high-touch surfaces that cause hospital-acquired infections, (3) to develop human-centered design recommendations. Methods: This mixed-method case study was conducted in a 23-bed urban hospital PICU. The activities, movements, and workflows of 13 RNs were recorded using spatial movement mapping, behavioral mapping, and clinical activity mapping. Frequency of RN contact with surfaces was documented to assess relative infection transmission risk. Face-to-face interviews were conducted with RNs to elicit their views on care delivery and their physical work environment. Results: Direct patient care occupied 50% of RNs’ time. Of the direct patient care workflow activities recorded, 26% were to prepare for care around the bedside, while 27% were for random travel between clean and soiled areas. The surfaces most frequently touched were (1) patient bedrails, (2) intravenous pumps and poles, (3) tubing and medical equipment, and (4) vital sign monitors. Conclusion: Value-added tasks account for only about 20% of nurses’ work. Combining technology and strategic interior design to streamline workflow and enhance infection prevention optimizes efficiency and empowers frontline providers to maximize their time at the bedside performing value-added tasks.
Not Just an Issue in Forested Regions: Investigating the Consumption and Trade of Pangolins in a Forest-Savannah Mosaic Area of Cameroon
Authors: Mouafo Alain D. T. , Ingram Daniel J. , Binda Valery A. , Ngwayi Itoe Constantine N. , Mayaka Theodore B. 
Published: August 2022

Background and research aims Cameroon hosts three species of pangolins and has recently been identified as a hub of pangolin trafficking. However, information on threats to pangolins needed to guide conservation efforts remains scarce, notably on consumption and trade patterns, and the prevalence of individuals trading pangolins. Local communities sharing the same habitats with pangolins can provide such information, which is useful to better target interventions. Methods Based on a snowball sampling approach and using interview surveys in 20 villages surrounding Mbam et Djerem National Park, we investigated the consumption of pangolins and its drivers, parts sold, selling prices, places sold and buyers, and employed the nominative technique to estimate the percentage of people within the surveyed population engaged in selling pangolins. Results Our results showed that both giant and white-bellied pangolins are locally consumed, mainly for their taste, and traded for meat and scales. Distance to the capital city Yaoundé, ethnolinguistic group, and education significantly affected the likelihood of consuming or trading white-bellied and giant pangolins. Selling and prices of giant pangolin meat and scales were significantly affected by distance to Yaoundé. The prevalence of people selling white-bellied and giant pangolins were higher in Tibati and Yoko compared to other municipalities. Implications for conservation Overall, our study provided information necessary for effective law enforcement and research-oriented decision-making for pangolin conservation. We recommend the establishment of consumption reduction campaigns focusing on taste preference, investigation of the impacts of the newly constructed national road on pangolin supply chains and trafficking, and increasing the involvement of local communities in the management process of Mbam et Djerem National Park.