bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and cognitive improvement following full-spectrum, high-cannabidiol treatment for anxiety: open-label data from a two-stage, phase 2 clinical trial
Authors: Dahlgren Mary Kathryn , Lambros Ashley M. , Smith Rosemary T. , Sagar Kelly A. , El-Abboud Celine , Gruber Staci A. 
Published: November 2022

Abstract
Background
Evidence suggests cannabidiol (CBD) has anxiolytic properties, indicating potential for novel treatment strategies. However, few clinical trials of CBD-based products have been conducted, and none thus far have examined the impact of these products on cognition.

Methods
For the open-label stage of clinical trial NCT02548559, autoregressive linear modeling assessed efficacy and tolerability of four-weeks of 1 mL t.i.d. treatment with a full-spectrum, high-CBD sublingual solution (9.97 mg/mL CBD, 0.23 mg/mL Δ−9-tetrahydrocannabinol) in 14 outpatients with moderate-to-severe anxiety, defined as ≥16 on the Beck Anxiety Inventory (BAI) or ≥11 on the Overall Anxiety Severity and Impairment Scale (OASIS).

Results
Findings suggest significant improvement on primary outcomes measuring anxiety and secondary outcomes assessing mood, sleep, quality of life, and cognition (specifically executive function) following treatment. Anxiety is significantly reduced at week 4 relative to baseline (BAI: 95% CI = [−21.03, −11.40], p < 0.001, OASIS: 95% CI = [−9.79, −6.07], p < 0.001). Clinically significant treatment response (≥15% symptom reduction) is achieved and maintained as early as week 1 in most patients (BAI = 78.6%, OASIS = 92.7%); cumulative frequency of treatment responders reached 100% by week 3. The study drug is well-tolerated, with high adherence/patient retention and no reported intoxication or serious adverse events. Minor side effects, including sleepiness/fatigue, increased energy, and dry mouth are infrequently endorsed.

Conclusions
Results provide preliminary evidence supporting efficacy and tolerability of a full-spectrum, high-CBD product for anxiety. Patients quickly achieve and maintain symptom reduction with few side effects. A definitive assessment of the impact of this novel treatment on clinical symptoms and cognition will be ascertained in the ongoing double-blind, placebo-controlled stage.
Genetic determinants for the racial disparities in the risk of prostate and testicular cancers
Authors: Uzamere Ivie , Wang Yinqiao , Zheng Tongzhang , Zhu Yong 
Published: November 2022

AbstractBackgroundA worldwide higher incidence of prostate cancer and lower incidence of testicular cancer in men of African ancestry compared to European ancestry has been observed previously. However, underlying mechanisms accounting for these observations are largely unknown.MethodsThe current study analyzed previously reported SNPs associated with either prostate cancer or testicular cancer to examine whether the risk allele frequency could help us understand the observed incidence disparities in men of African ancestry and European ancestry. Both t-test and regression analysis were performed.ResultsHere we show that men of African ancestry are more likely to have risk alleles of prostate cancer and less likely to have risk alleles of testicular cancer compared to men of European ancestry.ConclusionsOur findings suggest that genetic factors may play an important role in the racial disparities in the risk of prostate and testicular cancers.
Locally convexified rigid tube MPC
Authors: Sun Haidi , Zhang Sixing , Dai Li , Raković Saša V. 
Published: November 2022

AbstractThis paper proposes a locally convexified rigid tube model predictive control for obstacle avoidance for linear, discrete‐time, systems subject to additive, bounded disturbances and state and control constraints. The inherently nonconvex obstacle avoidance constraints are locally convexified and converted into closed polyhedral constraints by deploying recent notions of safe sets and tubes. The proposed method leverages these recent notions of safe sets and tubes to reformulate the original nonconvex optimization problem for obstacle avoidance within the context of disturbances into a computationally highly efficient, strictly convex quadratic programming problem. In order to analyze the separation between a predicted state set and each obstacle avoidance constraint set, we employ the Euclidean distance between these two sets and the radius of the Chebyshev ball of their intersection. In the strict separation case, the separating hyperplanes are constructed by utilizing the separation theorem for convex sets, while in the weak separation case, the construction of separating hyperplanes is achieved through the use of the separation theorem and the properties of convex cones. The proposed method provides guarantees of strong system theoretic properties such as robust recursive feasibility, robust positive invariance and robust stability of the controlled uncertain system. A simulation example is also provided to numerically verify the effectiveness of the proposed method.
A novel starting method with reactive power compensation for induction motors
Authors: Chang Yufang , Yan Huaicheng , Huang Wencong , Quan Rui , Zhang Yu 
Published: November 2022

AbstractThis paper investigates several traditional startup methods for induction motors. Since a large starting current and a reactive power may lead to a deep voltage drop and cause a potential damage to induction motors and other devices in the same power grid, a novel starting method is proposed for induction motors based on the autotransformer and the magnetically controlled reactor (ATMCR). Then, a reactive power dynamical compensation strategy is developed to improve the power factor and overcome the voltage drop effectively. The main advantage of the proposed approach is that the starting current of induction motors is reduced in the starting period and compensate the reactive power simultaneously. In simulation, a parameter identification method is presented to deal with simulation parameters and the motor's nameplate parameters inconsistencies problem. Finally, simulation and experiment are provided to verify the effectiveness of the proposed approaches.
Enhancing power quality of high‐speed railway traction converters by fully integrated T‐LCL filter
Authors: Al‐Barashi Maged , Meng Xiangyu , Liu Zhigang , Saeed Mahmoud S. R. , Tasiu Ibrahim Adamu , Wu Siqi 
Published: November 2022

AbstractModulating the traction converters produces current harmonics at the switching frequencies and their multiples. These harmonics should be minimized to meet the network specifications. The LC‐trapped filters, tuned to these frequencies, can easily meet this requirement, but the existing applicable trap filters have not been studied with the traditional traction system topologies. Thus, this paper presents a trapped LCL filter with an LC resonator on the converter side, called a fully integrated T‐LCL filter, for the traction power supply system. The model and analysis reported in this research demonstrate that the presented filter has several advantages, which can be summarized by: reducing the size by winding many coils through magnetic integration, attenuating the switching frequency and its multiple harmonics that reduce the current total harmonic distortion, assuring durability against the filter parameters differences, and preserving system stability under transient conditions. The proposed filter can become a promising trap filter based on these advantages. Simulation models of an ac/dc single‐phase traction rectifier with the proposed filter were created and tested in MATLAB/Simulink, verifying its superiority. Finally, the filter is validated by performing hardware‐in‐the‐loop experiments.
Distributed reactive power control strategy based on adaptive virtual reactance
Authors: Wang Hongdong , Wang Xiaogang 
Published: November 2022

AbstractIn high‐voltage microgrid, the line impedance is mainly inductive and the reactive power of the load cannot be shared equally and reasonably due to the transmission line impedance mismatches. This paper proposes a distributed reactive power control strategy combined with an adaptive virtual reactance method. The proposed control strategy does not require line impedances estimation or a central controller; each DG only needs information from its neighbours to achieve control of the reactive power, which can reduce communication costs and improve system reliability. An adaptive compensator is employed to reduce voltage deviations. Finally, MATLAB/Simulink simulation and hardware‐in‐the‐loop experiment are conducted to verify the effectiveness of the proposed control strategy.
Management of Antithrombin Deficiency in Pregnancy
Authors: Hart Christina , Rott Hannelore , Heimerl Susanne , Linnemann Birgit 
Published: November 2022

AbstractAntithrombin (AT) deficiency is a high-risk thrombophilia and a rare condition. The risk of venous thromboembolism (VTE) is increased in AT-deficient women during pregnancy and the postpartum period and is especially high in women with a prior history of VTE. A thorough assessment of VTE risk is recommended in pregnant AT-deficient women, comprising the degree and type of AT deficiency, genetic mutations, personal and family history, and additional preexisting or pregnancy-specific risk factors. Due to a lack of adequate study data, there is limited guidance on the management of AT deficiency in pregnancy, including the need for prophylactic anticoagulation, the appropriate dose of low-molecular-weight heparin (LMWH), and the role of AT substitution. LMWH is the medication of choice for the pharmacological prophylaxis and treatment of VTE in pregnancy. Patients with a history of VTE should receive full-dose LMWH during pregnancy and the postpartum period. AT concentrates are a treatment option when anticoagulation is withheld in potentially high-risk events such as childbirth, bleeding, or surgery and in cases of acute VTE despite the use of therapeutic dose anticoagulation. Women with AT deficiency should be counseled at specialized centers for coagulation disorders or vascular medicine, and close cooperation between obstetricians and anesthesiologists is warranted before delivery and during the peripartum period.
Cystic endometrial hyperplasia and uterine adenocarcinoma in two miniature pigs
Authors: Dürlinger Sophie , Knecht Christian , Gumpenberger Michaela , Brunthaler René , Ladinig Andrea , Schäfer-Somi Sabine 
Published: November 2022

AbstractDue to the increasing popularity of minipigs as pets, the frequency of presentation to the veterinarian is increasing as well. In addition to routine measures such as claw trimming, vaccination and antiparasitic treatment, diagnostics, and therapy of diseased minipigs are also common activities in the veterinary practice. In recent years, we have noticed more and more pathological changes of the female genital tract of uncastrated minipigs. There are also some case reports available in the international literature in this regard. The following case report describes the diagnostic procedures and ovariohysterectomies of 2 13-year-old female minipigs in detail. In these cases, uterine adenocarcinoma, and uterine carcinoma, respectively, combined with cystic endometrial hyperplasia (CEH) of the endometrium were diagnosed.
Von Willebrand Disease—Specific Aspects in Women
Authors: Eladly Fagr , Miesbach Wolfgang 
Published: November 2022

AbstractVon Willebrand disease (VWD) is the most common inherited bleeding disorder, which results from a deficiency or dysfunction of von Willebrand factor (VWF). The major symptoms of patients affected by VWD include mucocutaneous and gastrointestinal bleeding, easy bruising, and prolonged provoked bleeding due to injury or surgery. Although women and men are equally likely to be affected by VWD, women continue to be disproportionately affected by the bleeding challenges. Women with VWD suffer from sex-specific symptoms, such as menorrhagia, and are at higher risk of reproductive problems and recurrent miscarriage. Furthermore, pregnant women with VWD are more likely at higher risk of suffering from primary and secondary peripartal hemorrhage and anemia and the need for transfusions. Despite being affected by gynecologic and obstetrical bleeding, women face multiple barriers in obtaining an accurate diagnosis. This constitutes a problem that needs to be addressed, and early appropriate medical care should be ensured. There are several effective treatment options for women with VWD that can significantly improve their quality of life, including desmopressin, VWF concentrates, hormonal therapy, and antifibrinolytic therapy. During pregnancy, the monitoring of VWF activity levels is essential. The peripartal management depends on the type of VWD and on the measured levels of VWF levels and activity prior to delivery.
Venous Thromboembolism in Women with Cancer with an Additional Focus on Breast and Gynecological Cancers
Authors: Matzdorff Axel 
Published: November 2022

AbstractCancer-associated venous thromboembolism (VTE) is common in women with cancer. Many clinical practice guidelines provide guidance for prevention and treatment; however, there are no specific recommendations for women. This is unfortunate because the proportion of women with breast- and gynecological cancers is high among patients with cancer-associated VTE. Thromboembolism often heralds cancer progression and poor prognosis and should—besides adequate anticoagulant management—also prompt reassessment and, if necessary, changes in cancer treatment. Recently, the new class of direct-acting oral anticoagulants (DOACs) has started to replace low-molecular-weight heparin as standard thromboprophylaxis and therapy in cancer patients. They are very effective, but they also carry a relevant risk of bleeding. Therefore, despite their ease of use, not every tumor patient qualifies for a DOAC, and this is especially true for gynecological tumor patients. Each prescription must be weighed individually. This review addresses specific aspects of VTE prophylaxis and management in women with cancer. Every physician who treats breast and gynecological cancers should be familiar with prophylaxis, diagnosis, and therapy of cancer-associated VTE. At the same time, patients should be informed by their physician what symptoms to look for and whom to contact if these symptoms occur, even outside of office hours and on weekends.
Imaging findings in a minipig with congenital portosystemic shunt
Authors: Schikowski Lisa , Schaub Sebastian , Thalmeier Sabine , Schneider Matthias 
Published: November 2022

AbstractA 15-month-old, male minipig was presented with a clinical history of seizure activity for one year. The minipig was the smallest among the littermates and was referred due to an elevated blood ammonia level with suspected portosystemic shunt (PSS). Ultrasound and CT angiography were consistent with a congenital extrahepatic PSS. To the author’s knowledge, this is the first description of a congenital extrahepatic PSS diagnosed by ultrasound and contrast-enhanced computed tomography in a minipig (pig). Partial shunt closure was performed by interventional stent application.
Befragung von Haltern von vom Aussterben bedrohten Schaf- und Ziegenrassen zum Einfluss des Wolfes auf die Tierhaltung
Authors: Glatzle Megan , Wagner Henrik , Feldmann Antje , Wehrend Axel 
Published: November 2022

Zusammenfassung
Gegenstand und Ziel Mit der weiteren Ausbreitung des Wolfes in Deutschland nehmen die Konflikte mit Tierhaltern zu. Es stellt sich zunehmend die Frage nach den Auswirkungen des Wolfsbestandes auf die Weidetierhaltung. Ziel der Studie war es daher, durch die Befragung von Tierhaltern den Einfluss des Wolfes speziell auf die Haltung von vom Aussterben bedrohter Schaf- und Ziegenrassen zu untersuchen und herauszufinden, welche Schutzmaßnahmen von den Tierhaltern gegen den Wolf ergriffen werden.
Material und Methoden Ein Fragebogen aus 11 Fragen wurde von der Gesellschaft zur Erhaltung alter und gefährdeter Haustierrassen e. V. (GEH) online gestellt und von 494 Schaf- und Ziegenhaltern aus ganz Deutschland anonym ausgefüllt und anschließend ausgewertet.
Ergebnisse 33 % der bedrohten Schaf- und 80 % der bedrohten Ziegenrassen werden von weniger als je 10 Tierhaltern gehalten, überwiegend in Hobbyhaltung oder zum Nebenerwerb. Die Aufgabe der Tierhaltung einzelner Tierhalter kann sich daher signifikant negativ auf den Fortbestand der jeweiligen Rasse auswirken. An den mittleren Herdengrößen der Herdbuchzuchten lässt sich in den letzten Jahren keine negative Auswirkung auf die Tierzahlen erkennen, obgleich die Mehrheit der Befragten ihre Weidetierhaltung durch den Wolf bedroht sieht. Beachtenswert ist, dass signifikant mehr Halter angeben, die Tiere abschaffen zu wollen (Halter außerhalb Wolfsgebiet), als dies bei konkreter Bedrohung der Fall ist (Halter im Wolfsgebiet). Genannte Präventionsmaßnahmen sind am häufigsten die Veränderung der Einfriedung und die Herausnahme bestimmter Flächen aus der Nutzung. Der Einsatz von Herdenschutzhunden spielt keine große Rolle.
Schlussfolgerungen Durch die Aufgabe der Tierhaltung einzelner Halter besteht die Gefahr der Verringerung der Rassendiversität bei kleinen Wiederkäuern. Daher benötigen diese einen besonderen Schutz, was bei der Planung und Festlegung von Kompensationsmaßnahmen berücksichtigt werden muss.
Influence of Exercise on Inferior Vena Cava Wall Interaction with Inferior Vena Cava Filters: Results of a Pilot In Vivo Porcine Study
Authors: Shahid M. Usman , Nirgudkar Neel , Chandra Vishnu , Gonzales Sharon , Kumar Abhishek 
Published: November 2022

Abstract
Objectives The aim of this study was to assess the effect of mild exercise on inferior vena cava (IVC) filter interaction with imaging and pathological features with the neighboring vessel wall utilizing a porcine model.
Materials and Methods After Institutional Animal Care and Use Committee (IACUC) approval, retrievable Option Elite IVC filters were implanted in six Yorkshire pigs utilizing the right common femoral vein approach under general anesthesia. Group A (n = 4) pigs remained sedentary for 4 weeks. Group B (n = 2) pigs were exercised using a harness and treadmill for 10 minutes/day for 4 days/week. At approximately 4 weeks, IVC venograms were performed and the pigs were sacrificed. After laparotomy, the IVC was ligated above and below the filter, excised and fixed in formalin. Gross and histological examination of the IVC was performed. Gross images of each sample were captured before removal of the filters. One longitudinal, one tangential, and five transverse representative sections were processed for paraffin sectioning and hematoxylin and eosin slides were prepared. A pathologist examined all tissues to assess differences between normal vein, group A and group B pigs. The pathologist provided an overall assessment and representative images.
Results All IVC filter implantations were technically successful without adverse effects. There was no incidence of caval thrombosis, filter strut fracture, or filter migration in either group. On gross pathological examination, IVC of the pigs in group B demonstrated more perivascular and mural fibrosis than those pigs in group A. Histopathological findings correlated with gross findings.
Conclusions In this pilot study, there were no incidence of IVC filter strut fracture, penetration or IVC occlusion in sedentary or exercised pigs. However, there tended to be more perivascular and mural fibrosis on pathological examination of inferior vena cavas from exercised pigs. Further larger scale studies may employ the porcine model to further understand the role exercise may play on IVC filter and caval wall interaction.
Headache in the Pediatric Population: Focus on Migraine
Authors: Irwin Samantha L. , Greene Kaitlin A. , Pavitt Sara J. , Ross Alexandra C. 
Published: November 2022

AbstractPediatric headache is a common condition with significant impact on quality of life and ability to function in academic, social, and extracurricular activities. Most pediatric patients seen in primary care and neurology clinics with headache have primary headache disorders. Diagnosis is largely based on clinical history. Imaging is rarely needed in the absence of red flag features. Careful diagnosis is important to guide appropriate treatment. Treatment focuses on a biopsychosocial model integrating lifestyle, pharmacologic and nonpharmacologic treatment modalities. As few therapies are approved in the pediatric population, treatments are often used off-label based on evidence extrapolated from adult studies. Outcomes vary over time but are generally favorable when headache disorders are diagnosed promptly and managed in a multidisciplinary setting.
Gesellschaft im Wandel: „Auch die Medizin braucht einen Reset!“
Authors: Randoll Ulrich G. 
Published: November 2022

ZusammenfassungLernen Sie den Standpunkt des Münchner Arztes Dr. med. Ulrich G. Randoll zum Thema Entwicklung der Medizin kennen, den er dem VPT-Bundesvorsitzenden zukommen ließ. Und folgen Sie unserer Einladung zum Dialog: Uns interessieren auch Ihre Gedanken zur Entwicklung der Physiotherapie und Ihre Meinung zur aktuellen Situation in der Medizin. Schreiben Sie uns gerne an:
presse@vpt.de
Update Pädiatrie (3): Überblick zur evidenzbasierten Physiotherapie bei Infantiler Zerebralparese
Authors: Ackermann Wencke , Stuhlfelder Ulrike 
Published: November 2022

ZusammenfassungEine frühe klinische Diagnose der infantilen Zerebralparese (ICP) wirkt sich günstig auf den Verlauf der Entwicklung des Kindes aus, optimiert die Neuroplastizität und beugt Komplikationen vor. Die beste Methode zur Früherkennung besteht aus einem MRT und standardisierten klinischen motorischen Untersuchungen. Die folgende Übersicht stellt einen neuen Therapieansatz vor und gibt einen Überblick über die Evidenz der Wirksamkeit therapeutischer Interventionen bei der ICP.
Dynamics of chiral domain walls under applied current in cylindrical magnetic nanowires
Authors: Fernandez-Roldan J. A. , Chubykalo-Fesenko O. 
Published: November 2022

The dynamics of two types of chiral magnetic domain walls in magnetic cylindrical nanowires under spin-polarized current are investigated by means of micromagnetic simulations. We show that Bloch point domain walls with chirality identical to that of the Oersted field can propagate without dynamical instabilities with velocities ∼300 m/s. The domain wall width is shown to widen at larger current densities limiting the velocity increase. For domain walls with opposite chirality, we observed a new pinning mechanism created by the action of the Oersted field, limiting their propagation distance even after chirality switching. Vortex–antivortex domain walls transform into Bloch point domain walls, and after that they can unexpectedly propagate either along or against the direction of the current. Our findings demonstrate that domain wall dynamics under current in cylindrical magnetic nanowires can result in a plethora of different behaviors that will have important implications for future 3D spintronic devices.