bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using the flexible analytic hierarchy process method to solve the emergency decision making of public health for COVID-19
Authors: Chung Hsiang-Yu , Chang Kuei Hu 
Published: October 2022

Abstract
The novel coronavirus COVID-19 was initially found in December 2019 in Wuhan, China. Since then, the COVID-19 virus has rapidly spread throughout the world, causing the collapse of medical systems and economic depression. In addition to providing various relief programs, many countries have implemented various anti-epidemic measures to stop the continuous deterioration of the epidemic and maintain the stability of their economies. Especially during the COVID-19 pandemic, emergency decision making and risk assessment is an important issue for guaranteeing the stable life of the people are considered emergency multicriteria decision making (MCDM) problems. The assessment information of the criteria simultaneously includes complete, incomplete and hesitant fuzzy linguistic information in emergency MCDM problems. The analytic hierarchy process (AHP) approach can effectively process MCDM problems; however, the traditional AHP approach cannot handle the incomplete and hesitant fuzzy linguistic information of emergency MCDM problems. In order to overcome these issues, this paper proposed a novel flexible AHP method to solve emergency MCDM problems under the COVID-19 pandemic, and adopted a numerical case about public health emergency decision making and risk assessment under the COVID-19 pandemic to verify the effectiveness and correctness of the proposed flexible AHP method.
Comparing Eurocode 8-5 and AASHTO methods for earth pressure analysis against centrifuge tests, finite elements, and the Generalized Coefficients of Earth Pressure
Authors: Pantelidis Lysandros , Christodoulou Panagiotis 
Published: October 2022

Abstract
This paper presents an exhaustive comparison of the earth pressure methods included in EN1998-5:2004 (use of Mononobe-Okabe method, M-O), prEN1998-5:2022 and AASHTO (M-O with half peak ground acceleration) standards, against contemporary centrifuge tests, finite elements, and the method proposed by the first author in 2019. The latter is a continuum mechanics approach for deriving earth pressure coefficients for any soil state between the “at-rest” state and the active or passive state, applicable to cohesive-frictional soils and both horizontal and vertical pseudo-static conditions. The same method also provides analytical expressions for the calculation of the required wall movement for the mobilization of the active (or passive) failure state, as well as for the mobilized shear strength values of soil. The comparison includes among others, centrifuge test results from two different studies, and results from 157 finite element models from two different programs. All experimental, numerical, and analytical results show that the EN19985-5:2004 method gives conservative to excessively conservative active earth pressure values, AASHTO’s approach fairly good behavior, while prEN1998-5:2022 excessively conservative values. For the passive state, all methods included in the above-mentioned standards, return unreliable and unconservative results. In contrast, the results obtained by the proposed method show a remarkable agreement with the respective ones obtained both by the finite element method and the various centrifuge tests. Also, it is shown that a pseudo-static earth retention analysis, can be replaced by a respective static analysis, just substituting the (c’,φ’) values of soil of the original problem with the mobilized ones.
Volatile organic compound (VOC) profile and plantlet growth of Aeollanthus suaveolens under conventional and alternative membrane systems
Authors: Araújo Diene Xavier , Rocha Tainá Teixeira , de Carvalho Alexandre Alves , Medeiros Ana Paula Ribeiro , Ribeiro Fernanda Naiara Santos , de Assis Rafael Marlon Alves , Bertolucci Suzan Kelly Vilela , Pinto José Eduardo Brasil Pereira 
Published: October 2022

Abstract
In conventional in vitro culture, plantlets are kept in closed containers to avoid contamination and drying of the explant. Ventilation inside the containers improves plant growth and affects secondary metabolism, as it modifies the microenvironmental conditions. Therefore, the objective of this study was to evaluate the effect of the use of ventilation systems on the growth characteristics and production of photosynthetic pigments and volatile organic compounds (VOCs) in Aeollanthus suaveolens Mart. ex Spreng. (Lamiaceae) cultured in vitro. Nodal segments containing one pair of leaves were cultured in a conventional system (NMS) and in natural ventilation systems with one (AMS1), two (AMS2) and four (AMS4) porous membranes. At 40 days, the plantlets were evaluated for growth, VOC concentration, and photosynthetic pigment production. The number of porous membranes used in the vial cap affected growth, photosynthetic pigments and VOCs. A higher number of porous membranes (AMS4) led to greater dry weight accumulation, increased production of photosynthetic pigments, and enhanced synthesis of (Z)-β-farnesene. Lower growth and fewer photosynthetic pigments, and increase linalool acetate synthesis were observed in the culture without the use of porous membranes (NMS). The leaf area of plantlets cultivated with the use of four membranes was 3.8 times greater than that of plantlets cultivated without the use of membranes. For the photoautotrophic cultivation of A. suaveolens in vitro, the use of natural ventilation with four membranes is recommended because it promotes better growth, increases the production of photosynthetic pigments and is superior to the conventional sealed system.
Conceptual design of a multistage hybrid desalination process for brine management and maximum water recovery
Authors: Kadi Khadije El , Janajreh Isam , Abedrabbo Sufian , Ali Mohamed Ibrahim 
Published: October 2022

Abstract
Hypersaline brine production from desalination plants causes huge environmental stress due to the untenable conventional discharge strategies. Particularly, brine production is expected to drastically increase in the coming few decades due to the increasing desalination capacity in attempts of forestalling water scarcity. Thereby, zero liquid discharge (ZLD) is a worth-considering solution for strategic brine management. ZLD or minimal liquid discharge (MLD) systems provide maximum water recovery with least or zero liquid waste generation and valuable salt production. In this work, a theoretical design of ZLD/MLD systems is proposed for RO brine management. Four different scenarios are investigated combining multistage freeze desalination (FD), multistage membrane distillation (MD), and eutectic freeze crystallization (EFC) technologies. Water recovery, water quality, as well as specific energy consumption (SEC) are evaluated. FD experiments showed that ice quality is reduced at greater crystallinity levels and initial concentration. Meanwhile, DCMD module was capable of producing 53 kg/(m2.h) of pure water operating with 69% thermal efficiency. Based on different configuration of the hybrid ZLD system, the proposed design can achieve water recovery between 40% up to 93% with SEC range of 28-114 kWh/m3. Results also showed that the produced water quality is even greater than drinkable water standards (500 mg/l). This work has provided great evidence in the practicality of ZLD/MLD systems for sustainable brine management.
SENP1 modulates chronic intermittent hypoxia-induced neuroinflammation and neuronal injury by inhibiting microglial migration via the de-SUMOylation of TOM1
Authors: Wang Hongwei , Wang Xu , Wang Yanmin , Yang Tianyun , Sun Jinyuan , Liu Song 
Published: October 2022

Abstract
Chronic intermittent hypoxia (CIH), a prominent characteristic of obstructive sleep apnea syndrome, accelerates OSAS-associated neurocognitive impairment by initiating neuroinflammation. Microglia play a vital role in neuronal development and detrimental phagocytosis through migration. SUMO-specific proteases 1 (SENP1) has been implicated in cells migration. However, the role of SENP1 in the progression of CIH-induced neuroinflammation of microglia remains unknown. We aimed to investigate the effect of SENP1 on microglial migration, neuroinflammation, neuronal injury and Aβ deposition after the CIH insult. The CIH model was established using an intermittent hypoxia device. SENP1 overexpression and knockdown were induced in vitro and in vivo, respectively. Results showed that CIH downregulated the expression of both SENP1 and TOM1, enhanced the SUMOylation of TOM1, and promoted microglial migration, neuroinflammation, neuronal apoptosis and neuronal Aβ42 deposition in vitro and in vivo. After SENP1 overexpression in vitro, the enhanced SUMOylation of TOM1 was inhibited; the expression of TOM1 and microglial migration were enhanced; neuroinflammation, neuronal apoptosis and neuronal accumulation of Aβ42 by CIH was significantly reduced. However, the administration of siRNA-TOM1 abolished the microglial migration, neuroinflammation, neuronal apoptosis and reduction of Aβ42 deposition. After SENP1 knockdown in vivo, the SUMOylation enhancement of TOM1 was accelerated, microglial migration was inhibited. Neuroinflammation, neuronal apoptosis, neuronal Aβ42 deposition, cognitive impairment was significantly aggrandized. Overall, the results demonstrated that SENP1 promoted microglial migration by regulating the de-SUMOylation of TOM1, thus contributing to neuroinflammation, neuronal apoptosis and the clearance of Aβ42 deposition induced by CIH injury.
Changes at glutamate tripartite synapses in the prefrontal cortex of a new animal model of resilience/vulnerability to acute stress
Authors: Musazzi Laura , Bonifacino Tiziana , Mingardi Jessica , Facchinetti Roberta , Sala Nathalie , Frumento Giulia , Ndoj Elona , Valenza Marta , Paoli Caterina , Ieraci Alessandro , Torazza Carola , Balbi Matilde , Muhammad Nadeem , Guerinoni Michele , Russo Isabella , Milanese Marco , Scuderi Caterina , Barbon Alessandro , Steardo Luca , Bonanno Giambattista , Popoli Maurizio 
Published: October 2022

Abstract
Stress represents a main risk factor for psychiatric disorders. Whereas it is known that even a single trauma may induce psychiatric disorders in humans, the mechanisms of vulnerability to acute stressors have been little investigated. In this study, we generated a new animal model of resilience/vulnerability to acute footshock (FS) stress in rats and analyzed early functional, molecular, and morphological determinants of stress vulnerability at tripartite glutamate synapses in the prefrontal cortex (PFC). We found that adult male rats subjected to FS can be deemed resilient (FS-R) or vulnerable (FS-V), based on their anhedonic phenotype 24 h after stress exposure, and that these two populations are phenotypically distinguishable up to two weeks afterwards. Basal presynaptic glutamate release was increased in the PFC of FS-V rats, while depolarization-evoked glutamate release and synapsin I phosphorylation at Ser9 were increased in both FS-R and FS-V. In FS-R and FS-V rats the synaptic expression of GluN2A and apical dendritic length of prelimbic PFC layers II–III pyramidal neurons were decreased, while BDNF expression was selectively reduced in FS-V. Depolarization-evoked (carrier-mediated) glutamate release from astroglia perisynaptic processes (gliosomes) was selectively increased in the PFC of FS-V rats, while GLT1 and xCt levels were higher and GS expression reduced in purified PFC gliosomes from FS-R. Overall, we show for the first time that the application of the sucrose intake test to rats exposed to acute FS led to the generation of a novel animal model of resilience/vulnerability to acute stress, which we used to identify early determinants of maladaptive response related to behavioral vulnerability to stress.
Methionine, Cysteine and Butylated Hydroxytoluene Enhance Cryosurvival of Ram Semen on Post-Thaw and Post-Incubation Time Points
Authors: Toker Mehmed Berk , Dogann Ibrahim 
Published: October 2022

Abstract
Despite there have been many experiments conducted about antioxidants, the best sole or combination use of antioxidants to include as a standard ingredient to freezing extenders yet to be found. This study conducted to investigate the different doses of methionine (2.5 and 5mM), cysteine (1 and 2mM) and butylated hydroxytoluene (BHT) (1 and 2mM) for ram semen cryopreservation on post-thaw and post-incubation (6 h) time points over spermatological parameters. Semen samples collected from Kivircik rams via electro-ejaculator in breeding season. After essential spermatological evaluations, appropriate samples were pooled then split into 7 equal aliquots to create study groups (antioxidant free control, 2.5mM methionine, 5mM methionine, 1mM cysteine, 2mM cysteine, 1mM BHT and 2mM BHT). Semen samples put into French straws (0.25mL) and freezing procedure (two-step) conducted via a programmable gamete freezer. At both time points; motility, HOST, PSA-FITC and TUNEL assays were conducted to discover the impacts of cryopreservation and incubation process over sperm cells. Antioxidant supplemented groups yielded better results comparing to control groups in terms of various spermatological parameters not only at post-thaw time point but after incubation for 6 h of time. The study demonstrated that supplementing sperm freezing extenders with abovesaid antioxidants may create new approaches to cryopreservation procedures and through increasing success rate of freezing, fertility results may increase to better results in near future.
Favorable Locations for new VGOS Antennas in India depending on the assessment of Geodetic Parameters and Environmental Factors
Authors: Dhar Sujata , Glaser Susanne , Heinkelmann Robert , Schuh Harald , Balasubramanian Nagarajan , Dikshit Onkar 
Published: October 2022

Abstract
VLBI simulation studies are carried out to investigate the impact of any proposed station or strategy on the geodetic parameters, like Earth Orientation Parameters (EOP) and Terrestrial Reference Frame (TRF). Generally, such studies are performed for making decisions on any new development in the existing VLBI network. Thus, for selecting the favorable locations for establishment of a VLBI antenna in India, simulation studies are performed on 42 potential locations to cover the whole Indian subcontinent. Furthermore, the simulation setup is divided into four scenarios that consider the current and future situations of the global VLBI network. Extensive simulation strategy is applied with optimized scheduling for each network geometry, Monte-Carlo simulations and analysis in the VieSched + + software. Just the results from the simulation are considered not enough for a comprehensive assessment of the realistic performance of locations, and hence, environmental factors are also investigated in the present study. The environmental factors affecting the operation and vulnerability of the VLBI technique at the potential locations are also incorporated in the present study. For this, a weighted scoring model is developed with the scores and weights based on the probable impact and occurrence frequency of disrupting environmental events, respectively. This approach will avoid the possibility of new VLBI station ending up in an unfavorable location in India and, underperforming substantially in terms of the expected improvement of geodetic parameters as determined from the simulation study. The VLBI Global Observing System (VGOS) network is being established at a global level to create a uniformly distributed network of the next generation VLBI system in order to meet the goals of the Global Geodetic Observing Systems (GGOS). India is planning to establish its first VGOS antenna and therefore, this study will help to mark the high-performance favorable locations for VGOS. The results show that the VGOS antenna at favorable locations in India outperform other locations by a factor of 1.1 to 5.0 in improvement percentage of derived geodetic parameters.
A novel therapeutic bispecific format based on synthetic orthogonal heterodimers enables T cell activity against Acute Myeloid Leukemia
Authors: Ali Abdullah , Burke Alan , Borot Florence , Du Xing , Churchill Michael , Ding Jian , Grass Albert , DeSouza Philip , Mukherjee Siddhartha 
Published: October 2022

AbstractMany therapeutic bispecific T-cell engagers (BiTEs) are in clinical trials. A modular and efficient process to create BiTEs would accelerate their development and clinical applicability. In this study, we present the design, production, and functional activity of a novel bispecific format utilizing synthetic orthogonal heterodimers to form a multichain modular design. Further addition of an immunoglobulin hinge region allowed a stable covalent linkage between the heterodimers. As proof-of-concept, we utilized CD33 and CD3 binding scFvs to engage leukemia cells and T-cells respectively. We provide evidence that this novel bispecific T-cell engager (termed IgGlue-BiTE) could bind both CD3 + and CD33 + cells and facilitates robust T-cell mediated cytotoxicity on AML cellsin vitro. In a mouse model of minimal residual disease, we showed that the novel IgGlue-BiTE greatly extended survival, and mice of this treatment group were free of leukemia in the bone marrow. These findings suggest that the IgGlue-BiTE allows for robust simultaneous engagement with both antigens of interest in a manner conducive to T cell cytotoxicity against AML. These results suggest a compelling modular system for bispecific antibodies, as the CD3- and CD33-binding domains can be readily swapped with domains binding to other cancer- or immune cell-specific antigens.
Improving mechanical performance and functionality of birch veneer with mechano-enzymatic nanocellulose coating
Authors: Orelma Hannes , Kunnari Vesa , Yamamoto Akio , Valkonen Mikko , Rautkari Lauri , Korpela Antti 
Published: October 2022

Abstract
In this study, we investigated the coating of birch veneers (BVs) with mechano-enzymatically manufactured nanofibrillated cellulose (meNFC) to improve mechanical strength and functionality. The meNFC has a broad particle size distribution and similar chemistry to lignocellulose materials, which are both beneficial properties in the coating of wood products. The veneer coating trials were carried out with a spray coating system developed to coat controllable thin coating layers. The spray coating produced uniform layers, which smoothened the BV surface significantly and was verified with scanning electron microscope imaging and optical profilometer measurements. The surface energy measurements showed that the meNFC is like cellulose, whereas the BV is like lignin. This observation proposes pre-treatment methods to secure a good adhesion level between the meNFC and BVs. The adhesion and compatibility of meNFC with the BV surface were measured with pull-off tests and surface energy measurements. The adhesion on a native BV surface was limited, while pre-treatment with sanding or using a primer significantly enhanced the adhesion. The meNFC coating slightly improved the BV transverse tensile strength (perpendicular to the wood veneer grain direction). A thermochromic functionality was installed on the BVs using meNFC as a binder. The produced thermochromic BVs displayed thermochromic behaviour; the coating could control the warming of the BVs subjected to solar radiation. The activation of a photocatalytic reaction of a meNFC coating containing TiO2 was studied on the wood surface under both ultraviolet and fluorescent light, indicating in a reduction of formaldehyde concentrations. The results also showed that wood discolouration was inhibited by meNFC with not only TiO2 but also only the meNFC coating. This study presents a practical approach to surface-treating wood materials with the meNFC to improve the mechanical and functional properties of wood products.
Gradient multi-layer ceramic fiber aerogel: Fabrication, anti-oxidation and thermal insulation
Authors: Zhong Yong , Li Hongyan , Liu Hongli , Liao Xiaolan , Wei Dongqing , Zhang Baolian , Lu Le 
Published: October 2022

Abstract
Aerogel is widely used in the field of thermal insulation. However, they exhibit brittleness and a dramatic increase in radiative heat transfer and effective thermal conductivity at high temperatures. Fiber composite aerogel achieved great progress, but the homogeneous structure hardly allowed heat convection, heat conduction, and heat radiation to be controlled simultaneously. In this paper, inspired by bamboo's multilayer and gradient structure, SiC fiber was prepared by electrostatic spinning, and TaSi2 and WSi2 particles were loaded on the fiber. Subsequently, SiC fiber was infiltrated by SiBCN ceramic precursors and then pyrolyzed to obtain gradient multilayer SiC/SiBCN ceramic fiber aerogel. The dense surface fiber reduced radiation heat transfer, and the porous structure of the aerogel decreased heat conduction and heat convection. The antioxidant particles improved the ceramic fiber aerogel's high-temperature oxidation resistance and thermal stability. The morphological structure, chemical composition, and thermal conductivity of ceramic fiber aerogel were characterized. The results showed that the gradient multilayer ceramic fiber aerogel had the comprehensive properties of ultra-low thermal conductivity, excellent infrared radiation shielding, and anti-oxidation performance. This study is expected to provide new ideas for constructing high-temperature thermal insulation ceramic aerogel.
Economic benefits of reduced deforestation are offset by excess deforestation – a counterfactual simulation
Authors: Knoke Thomas , Hanley Nick , Paul Carola 
Published: October 2022

Abstract
Assessment of the effectiveness of policies to preserve natural forests and the eco-nomic benefits we derive from them is of high international relevance. Here we use a counterfactual simulation approach to compare observed and expected deforesta-tion for Brazil, DR Congo and Indonesia. We reveal changes in the social costs of carbon (SCC), which coincide with command-and-control policies, climate anoma-lies, armed conflicts and pre-election promises. Our simulation of counterfactual country-level deforestation assumes that farmers seek satisfactory land-use profits. The approach integrates market data (1990-2019), but also accounts for heteroge-neous expectations. Phases with reduced deforestation saved 11% to 26% of SCC, while phases with excess deforestation caused 6% to 28% more SCC. In sum, a comparison with counterfactual deforestation levels showed forest savings of 11.1 million hectares (11% of the expected deforestation 2001-2019), but also excess deforestation of 11.3 million hectares. Our results confirm ongoing disastrously high SCC of forest losses.