bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological characteristics of socially significant infectious diseases as an indicator of the quality of life of the population
Authors: Leshchenko Ya. A. , Lisovtsov A. A. , Bazyaeva M. A. 
Published: May 2022

Background. Incidence and prevalence of socially significant infectious diseases are the most important indicators of the quality of life and sanitary and epidemiological well-being of the population.The aim is to identify structural, quantitative and dynamic features of incidence and prevalence of socially significant infectious diseases among the population in the post-Soviet period (on the example of the Irkutsk region).Methods. The materials of the forms of federal statistical observation № 2, № 12, databases posted on the websites of the Federal State Statistics Service, the Unified Interdepartmental Information and Statistical System, the Center for Demographic Research of the Russian School of Economics were used in the study. An epidemiological analysis of morbidity indicators and a comparative assessment with the average Russian data have been carried out. Trend analysis was performed by linear regression analysis using the SPSS software (IBM Corp., USA).Results. The highest levels of tuberculosis prevalence in the Irkutsk region were noted in the period from 1999 to 2013 (352.1–436.9 0/0000). The incidence rate of syphilis increased by 1997 to the maximum value – 431.4 0/0000; in subsequent years, the incidence rate decreased, amounting to 28.8 0/0000 in 2019. Very high incidence rates of gonorrhea, trichomoniasis, chlamydia were noted in the region until the end of the 2000s. The dynamics of the prevalence of HIV infection since 1999 was characterized by a rapid increase in the indicator (in 2018 – 1995.0 0/0000), which made the region one of the most unfavorable in the country for this type of pathology. Thus, in the Irkutsk region since the second half of the 1990s until the late 2000s – early 2010s there was a pronounced increase in the incidence of socially significant infectious diseases to very high values, significantly exceeding the national average. In the subsequent period (2012–2019), there was a consistent decrease in the incidence rate.Conclusion. The quality of life of the population of Siberia in the post-Soviet period suffered to the greatest extent. This led to a rapid increase in the levels of morbidity with socially significant infectious diseases. A transition to the state model of the advanced development of human potential is required to reduce morbidity to an acceptable level.
Knot Types Used by Transformable and Rigid Linear Structural Systems
Authors: Elipe Mª Dolores Álvarez 
Published: May 2022

A knot is the joining place between two or more constructive elements in a framework or structure. They have a fundamental importance in the structure, according to their design they will be able to give a geometric configuration or another to the system and will also absorb certain forces or others. Depending on the movements they allow to the bars, there are rigid knots, articulated knots and slip knots. In this paper a study of cases about rigid knots or embedments used by structural systems so far will be presented. These types of knots prevent the rotation and movement of the constructive elements used for construction. In this paper also a study of cases about the articulated and slip knots used by transformable structural systems so far will be presented. An articulated knot allows the rotation but not the movement of the elements. A slip knot prevents movement in one of the three axes of the reference system, but not in the others, nor in the rotation between the elements. The research is focused in presenting a summary and comparison of rigid knots, articulated knots and slip knots that have been used in the structural design of some architecture. The union systems research will be crucial in this study. The investigation shows an important state of the art that provides technical solutions to apply on novel architectures based on rigid structural systems and articulated and slip structural systems. The research is useful to produce the current constructive solutions based on these constructive systems.
Determination of Heavy Metals Concentration in Soil and Leafy Vegetables in Urban Expressway and Peri-urban Road Farms of Lagos State, Nigeria
Authors: Adewale Peter Sanjo , Makinde Sunday Clement Olubunmi , Kusemiju Victor Owolola , Obembe Olawole O. 
Published: May 2022

Farmers have long considered urban agriculture as a panacea to urban food insecurity. However, growing food in cities is faced with many challenges like food contamination. Past studies on leafy vegetables focused on vegetables cultivated in urban centres. However, this paper aimed to determine and compare the level of heavy metals concentrations in soil and leafy vegetables in Urban Expressway Farms (UEF) and Peri-urban Road Farms (PRF) in Lagos, Nigeria. These two locations were purposefully selected. Soil Auger was used to drill holes to the required soil depth to collect soil samples. Sample of Amaranthus hybridus, Celosia argentea and Corchorus olitorius were collected using “envelope” principle. Pb, Cd and Mn residues in the samples were digested and determined using Atomic Absorption Spectrophotometer. The collected data were analysed using mean, standard deviation and Analysis of Variance. The mean pH value for UEF soil is 6.5 while PRF soil is 6.6. The highest Pb (0.93±0.06) was recorded in Celosia argentea at UEF. The highest mean concentration of Cd (0.51±0.11) was recorded in Amaranthus hybridus at UEF. The highest concentration for Mn was recorded in Amaranthus hybridus (0.98±0.02) at UEF. The concentrations of Pb in Celosia argentea at UEF 5 m from the expressway and Cd concentration in Amaranthus hybridus at 10 m from expressway were above the WHO/FAO permissible levels in vegetables. Level of heavy metal residue observed in soil and vegetables under this study were mostly influenced by the location of the farm-environment and not mainly the vegetable type. The relative concentrations of Pb and Cd in all the three leafy vegetables raise some serious environmental concerns and need to be monitored regularly to prevent consumption of contaminated leafy vegetables. Farmers are encouraged to cultivate in fields far away from expressway.
APPLICATION OF EDUCATIONAL DIALOGUE TRAINING EXERCISES IN THE SCHOOL COURSE OF ECONOMIC AND SOCIAL GEOGRAPHIES OF UKRAINE
Authors: Tkachenko O.L. 
Published: May 2022

O.L. Tkachenko. Postgraduate of the Chair o f Pedagogical Creativity, Sumy State Pedagogical University.
The use of exercises o f educational dialogue in the school course of ,,Economic and social geography o f Ukraine”.
For the purpose of providing with conditions of harmonious development of a pupil s personality in educational establishments of general education we have developed a set of exercises of educational dialogue. The use of the exercises, which are adopted to the course of ,,Economic and Social Geography o f Ukraine (9th form)”, is analyzed in the theses. Examples are given.
PEDAGOGICAL CONDITIONS OF IMPROVEMENT VOCAL AND CHORAL SKILLS OF STUDENTS IN MUSIC LESSONS
Authors: Ivanchenko I.V. 
Published: May 2022

її is important for receiving positive results in a vocal-choral work to know and to create pedagogical conditions of rising of the quality of the vocalchoral work in the process o f pupils' education.
Pedagogical conditions of form ing o f quality of vocal-choral work mean specially created conditions owing to which deep understanding of aesthetic content of a musical composition are carried out and its influence tothe personality strengthen.
DIFFERENT APPROACHES TO THE DEFINITION OF THE CONCEPT OF “NEED FOR SELF-REALIZATION” IN PROFESSIONAL ACTIVITY
Authors: Ponomarenko N.V. 
Published: May 2022

The definition of “need” and its place in student's professional activity in higher educational establishment is studied in this work.
The survey of having scientific researches in this field applied to pedagogy, psychology and philosophy is made. The analysis of works let us affirm that the definition “need” is one of the main definitions in theory of person development. In its turn, the highest constituent of definition of “need ” is the definition “need of self-realization in professional activity”.
An insufficient research of these definitions in the context of professional activity of students gives the reasons for further learning and analyzing of this problem.
It was learned that the definitions “need” and “self realization” have the qualities characterizing the forms of man's growth to personal and professional maturity.
A New Integral Transform “Rishi Transform” with Application
Authors: Kumar R. , Chandel J. , Aggarwal S. 
Published: May 2022

In this paper, authors propose a new integral transform “Rishi Transform” with application to determine the exact (analytic) solution of first kind Volterra integral equation (V.I.E.). For this purpose, authors first derived the Rishi transform of basic mathematical functions (algebraic and transcendential) and then the fundamental properties of Rishi transform is discussed, which can be used for solving ordinary differential equations (O.D.E), partial differential equations (P.D.E.), delay differential equations (D.D.E.), fractional differential equations (F.D.E.), difference equations (D.E.), integral equations (I.E.) and integro-differential equations (I.D.E.). After this, authors determined the exact (analytic) solution of general first kind V.I.E.. They have considered three numerical problems and solved them completely step by step for explaining the utility of Rishi transform. Results depict that the proposed new integral transform "Rishi Transform" provides the exact results for first kind V.I.E. without doing complicated calculation work.
Penerapan Model Pembelajaran Discovery Learning Untuk Meningkatkan Hasil Belajar Siswa Kelas XI di SMA Negeri 1 Kota Bima Tahun Pelajaran 2021/2022
Authors: Syaiful Syaiful 
Published: May 2022

Penelitian bertujuan mengetahui Penerapan Model Pembelajaran Discovery Learning Untuk Meningkatkan Hasil Belajar Siswa Kelas XI di SMA Negeri 3 Kota Bima tahun pelajaran 2020/2021. Jenis penelitian adalah Penelitian Tindakan Kelas. Subyek dalam penelitian ini adalah siswa kelas XI SMA Negeri 1 Kota Bima tahun pelajaran 2021/2022 dengan jumlah 25 siswa. Rancangan penelitian ini menggunakan rancangan penelitian tindakan kelas dengan dua siklus. Setiap siklus meliputi tahap perencanaan, pelaksanaan, pengamatan, dan refleksi. Kesimpulan yang dapat diambil dalam penelitian ini adalah penerapan model pembelajaran discovery learning dapat meningkatkan Hasil Belajar siswa kelas XI di SMA Negeri 1 Kota Bima tahun pelajaran 2021/2022. Pada siklus I hasil belajar siswa yang tuntas sebanyak 16 orang dengan persentase ketuntasan (64%). Sedangkan pada siklus II yang tuntas 24 orang siswa (96%)
Predictive Value of Plasma Big Endothelin-1 in Adverse Events of Patients With Coronary Artery Restenosis and Diabetes Mellitus: Beyond Traditional and Angiographic Risk Factors
Authors: Ma Yue , Tian Tao , Wang Tianjie , Wang Juan , Guan Hao , Yuan Jiansong , Song Lei , Yang Weixian , Qiao Shubin 
Published: May 2022

BackgroundPatients with diabetes are a high-risk group for coronary in-stent restenosis (ISR), so it would be valuable to identify biomarkers to predict their prognosis. The plasma big endothelin-1 (big ET-1) level is closely related to cardiovascular adverse events; however, for patients with ISR and diabetes who undergo percutaneous coronary intervention (PCI), whether big ET-1 is independently correlated with prognosis is still uncertain.MethodsPatients with drug-eluting stent (DES) restenosis who underwent successful re-PCI from January 2017 to December 2018 at the Chinese Academy of Medical Sciences Fuwai Hospital were enrolled and followed up for 3 years. The patients were divided into the tertiles of baseline big ET-1. The primary end points were major adverse cardiovascular events (MACEs): cardiac death, non-fatal myocardial infarction (MI), target lesion revascularization (TLR), and stroke. A Cox multivariate proportional hazard model and the C-statistic were used to evaluate the potential predictive value of big ET-1 beyond traditional and angiographic risk factors.ResultsA total of 1,574 patients with ISR were included in this study, of whom 795 were diabetic. In patients with ISR and diabetes, after an average follow-up of 2.96 ± 0.56 years, with the first tertile of big ET-1 as a reference, the hazard ratio [HR] (95% CI) of MACEs after adjustment for traditional and angiographic risk factors was 1.24 (0.51–3.05) for the second tertile and 2.60 (1.16–5.81) for the third. Big ET-1 improved the predictive value for MACEs over traditional risk factors (C-statistic: 0.64 vs. 0.60, p = 0.03). Big ET-1 was not significantly associated with the risk of MACEs in patients without diabetes.ConclusionIncreased plasma big ET-1 was associated with a higher risk of adverse cardiovascular prognosis independent of traditional and angiographic risk factors, and therefore, it might be used as a predictive biomarker, in patients with ISR and diabetes.
Diabetes Is the Strongest Predictor of Limited Exercise Capacity in Chronic Heart Failure and Preserved Ejection Fraction (HFpEF)
Authors: Berisha-Muharremi Venera , Henein Michael Y. , Dini Frank L. , Haliti Edmond , Bytyçi Ibadete , Ibrahimi Pranvera , Poniku Afrim , Batalli Arlind , Tafarshiku Rina , Elezi Shpend , Bajraktari Gani 
Published: May 2022

Background and AimType 2 diabetes mellitus (T2DM) is a known risk factor in patients with heart failure (HF), but its impact on phenotypic presentations remains unclear. This study aimed to prospectively examine the relationship between T2DM and functional exercise capacity, assessed by the 6-min walk test (6-MWT) in chronic HF.MethodsWe studied 344 chronic patients with HF (mean age 61 ± 10 years, 54% female) in whom clinical, biochemical, and anthropometric data were available and all patients underwent an echo-Doppler study and a 6-MWT on the same day. The 6-MWT distance divided the cohort into; Group I: those who managed ≤ 300 m and Group II: those who managed &gt;300 m. Additionally, left ventricular (LV) ejection fraction (EF), estimated using the modified Simpson's method, classified patients into HF with preserved EF (HFpEF) and HF with reduced EF (HFrEF).ResultsThe results showed that 111/344 (32%) patients had T2DM, who had a higher prevalence of arterial hypertension (p = 0.004), higher waist/hips ratio (p = 0.041), higher creatinine (p = 0.008) and urea (p = 0.003), lower hemoglobin (p = 0.001), and they achieved shorter 6-MWT distance (p &lt; 0.001) compared with those with no T2DM. Patients with limited exercise (&lt;300 m) had higher prevalence of T2DM (p &lt; 0.001), arterial hypertension (p = 0.004), and atrial fibrillation (p = 0.001), higher waist/hips ratio (p = 0.041), higher glucose level (p &lt; 0.001), lower hemoglobin (p &lt; 0.001), larger left atrium (LA) (p = 0.002), lower lateral mitral annular plane systolic excursion (MAPSE) (p = 0.032), septal MAPSE (p &lt; 0.001), and tricuspid annular plane systolic excursion (TAPSE) (p &lt; 0.001), compared with those performing &gt;300 m. In the cohort as a whole, multivariate analysis, T2DM (p &lt; 0.001), low hemoglobin (p = 0.008), atrial fibrillation (p = 0.014), and reduced septal MAPSE (p = 0.021) independently predicted the limited 6-MWT distance.In patients with HFpEF, diabetes [6.083 (2.613–14.160), p &lt; 0.001], atrial fibrillation [6.092 (1.769–20.979), p = 0.002], and septal MAPSE [0.063 (0.027–0.184), p = 0.002], independently predicted the reduced 6-MWT, whereas hemoglobin [0.786 (0.624–0.998), p = 0.049] and TAPSE [0.462 (0.214–0.988), p = 0.041] predicted it in patients with HFrEF.ConclusionPredictors of exercise intolerance in patients with chronic HF differ according to LV systolic function, demonstrated as EF. T2DM seems the most powerful predictor of limited exercise capacity in patients with HFpEF.
Evidences of Bedrock Forcing on Glacier Morphodynamics: A Case Study in Italian Alps
Authors: Dematteis Niccolò , Giordan Daniele , Perret Paolo , Grab Melchior , Maurer Hansruedi , Troilo Fabrizio 
Published: May 2022

In mountain glaciers, the influence of bedrock geometry on glacier surface morphology is often assumed; quantitative evidence, however, is rare. In our research, we measured the ice thickness of the Planpincieux Glacier (North-west Italy) and detected the bedrock topography using ground-penetrating radar. Additionally, we investigated the glacier surface morphology using structure from motion and the glacier kinematics using digital image correlation of terrestrial images. A digital terrain analysis showed evidence of recurrent crevasses whose position corresponded to bedrock steps. On average, since 2014, their positions varied between 6 and 14 m and were 40 ± 8 m downstream of the bedrock steps. Bedrock and glacier topography presented out-of-phase correlated undulations that approximately fit a sinusoidal function of different amplitude. Moreover, we show the morphological evolution of an unstable sector whose thickness at the end of the ablation seasons has remained approximately constant since 2014. Contrarily, the ice melting during the 2020 ablation season caused a volume loss of &gt;30%. Since, in general, the damages provoked by a potential ice avalanche depend primarily on the involved volume, this finding demonstrates that frequent morphology monitoring is essential for correct glacial hazard assessment.
Identification of Immune-Related Genes for Risk Stratification in Multiple Myeloma Based on Whole Bone Marrow Gene Expression Profiling
Authors: Wang Qiang-Sheng , Shi Qi-Qin , Meng Ye , Chen Meng-Ping , Hou Jian 
Published: May 2022

Background: Multiple myeloma (MM) is characterized by abnormal proliferation of bone marrow clonal plasma cells. Tumor immunotherapy, a new therapy that has emerged in recent years, offers hope to patients, and studying the expression characteristics of immune-related genes (IRGs) based on whole bone marrow gene expression profiling (GEP) in MM patients can help guide personalized immunotherapy.Methods: In this study, we explored the potential prognostic value of IRGs in MM by combining GEP and clinical data from the GEO database. We identified hub IRGs and transcription factors (TFs) associated with disease progression by Weighted Gene Co-expression Network Analysis (WGCNA), and modeled immune-related prognostic signature by univariate and multivariate Cox and least absolute shrinkage and selection operator (LASSO) regression analysis. Subsequently, the prognostic ability of signature was verified by multiple statistical methods. Moreover, ssGSEA and GSEA algorithm reveled different immunological characteristics and biological function variation in different risk groups. We mapped the hub IRGs by protein-protein interaction network (PPI) and extracted the top 10 ranked genes. Finally, we conducted vitro assays on two alternative IRGs.Results: Our study identified a total of 14 TFs and 88 IRGs associated with International Staging System (ISS). Ten IRGs were identified by Cox -LASSO regression analysis, and used to develop optimal prognostic signature for overall survival (OS) in MM patients. The 10-IRGs were BDNF, CETP, CD70, LMBR, LTBP1, NENF, NR1D1, NR1H2, PTK2B and SEMA4. In different groups, risk signatures showed excellent survival prediction ability, and MM patients also could be stratified at survival risk. In addition, IRF7 and SHC1 were hub IRGs in PPI network, and the vitro assays proved that they could promote tumor progression. Notably, ssGSEA and GSEA results confirmed that different risk groups could accurately indicate the status of tumor microenvironment (TME) and activation of biological pathways.Conclusion: Our study suggested that immune-related signature could be used as prognostic markers in MM patients.
The Association Between Adverse Childhood Experiences and Postpartum Depression
Authors: Prentice Danielle M. , Otaibi Banan W. , Stetter Christy , Kunselman Allen R. , Ural Serdar H. 
Published: May 2022

ObjectiveAdverse childhood experiences (ACEs) are linked to worsening overall health outcomes and psychological diagnoses. Routine screening, particularly in patients with postpartum depression (PPD), would identify patients who could benefit from interventions to prevent the perpetuation of ACEs and establish a system of preventative care to mitigate the risks of adverse health outcomes associated with high ACE scores. The purpose of this study is to explore the link between ACEs and PPD to advocate for the use of the ACE questionnaire as a routine screening tool in all pregnant patients diagnosed with PPD. We hypothesize that a cohort of patients with PPD will be more likely to have high-risk ACE scores than the general female population.Study DesignOur IRB approved, retrospective cohort study identified all patients diagnosed with PPD at an academic medical center between January 2015 and December 2019. The subjects were identified using retrospective chart review. Subjects were recruited via telephone and asked to complete an ACE questionnaire. Questionnaires were sent via RedCap. ACE scores were calculated, categorized as 0, 1, 2, 3, or 4 or more ACEs, and compared to the prevalence in the original Kaiser-CDC ACE study female cohort using a chi-square goodness-of-fit test.ResultsThere were 132/251 surveys completed (53% response rate). In our PPD population, 19.3% had 0 ACEs, 17.0% had 1 ACE, 13.1% had 2 ACEs, 16.5% had 3 ACEs, and 34.1% had 4 or more ACEs. These percentages were significantly different from the Kaiser-CDC ACE Study percentages of 34.5, 24.5, 15.5, 10.3, and 15.2%, respectively (p &lt; 0.001).ConclusionOur unique study showed that women with PPD are more likely to have high-risk ACE scores than the general female population. This finding has important implications in regards to counseling, intervening to prevent perpetual ACEs, and establishing important provider-patient relationships for life-long preventative care.Non-gendered language is used when possible throughout. However, the wording from studies cited in this paper was preserved.