bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supply chain relational capital and firm performance: an empirical enquiry from India
Authors: Pant Pushpesh , Dutta Shantanu , Sarmah S.P. 
Published: June 2022

PurposeThe purpose of this paper is to examine how over-reliance on buyer-supplier relational capital (created through the interconnected supply chain and social network) impacts firm performance in the context of the emerging market, i.e. India.Design/methodology/approachThe study uses the Prowess database (on Indian firms) to identify the firms that rely heavily on relational capital and employs panel data regression analyses to test the effect of relational capital on firm performance (supply chain performance and financial performance).FindingsThe results show that over-reliance on relational capital leads to lower supply chain performance (proxied by supply chain cycle) and financial performance (proxied by Tobin's Q). The results also reveal that supply chain performance mediates the relationship between over-reliance on relational capital and financial performance. Together, these results indicate that over-reliance on relational capital created through the interconnected supply chain and social network for supply chain management may negatively affect a firm's competitive advantage, which in turn can significantly impede its financial performance.Originality/valueIn light of the supply chain literature and relevant theories, the study develops an objective understanding of over-reliance relational capital created through the interconnected supply chain and social network, by relying on a large panel dataset of manufacturing firms and hence contributes to the supply chain literature. Also, it presents a novel idea to operationalize the measure for relational capital using the Prowess database.
Financial integration and capital structure decisions of listed firms: evidence from China
Authors: Ahmed Ahsan , Zainudin Rozaimah , Shaharuddin Shahrin Saaid 
Published: June 2022

PurposeThis paper investigates the impact of financial integration on the capital structure of the firms operating in mainland China, examining the firm-level and country-level integrating variables for 2,878 listed Chinese firms over the period of 1991–2016 in regard to the firms' capital structures. Finally, the study revisits the associations for the state-owned and multinational firms in the context of China.Design/methodology/approachA large sample of unbalanced data from firms were used to explore the relationship firm-level and country-level integrating variables has with firm leverage and maturity; this is accomplished using the fixed effect model. For robustness, a system-generalised method of moments was used.FindingsThe results indicate that internationalisation positively impacts the leverage and debt maturity of all listed Chinese firms and multinational firms and that state-owned firms are financed mainly by the state. For country-level integration, the authors find that credit and equity markets are negatively related to a firm's leverage. A negative relation with credit markets suggests that Chinese firms have much cheaper financing options than the benefits that arise from credit market integration. Moreover, the effect of equity market integration is more pronounced on Chinese firms' capital structure and debt maturity than credit market integration.Practical implicationsThe results provide valuable implications of financial integration for policymakers as well as capital structure decision-making for managers in China.Originality/valueFew studies have examined the impact of integration on firms' capital structures in developing countries. After controlling for unobserved heterogeneity and endogeneity, this study adds new multilevel integration evidence on the capital structure of Chinese firms.
The impact of innovation aspiration shortfall and CEO origin on emerging economy firms' international expansion: evidence from China
Authors: Zhong Xi , Chen Weihong , Ren Ge 
Published: June 2022

PurposeWhether and when the innovation aspiration shortfall (e.g. innovation performance lower than aspirations) will affect emerging economy firms (EEFs)' international expansion remains an important unanswered theoretical and practical question.Design/methodology/approachBased on performance feedback theory, this study explores the impact of innovation aspiration shortfall on EEFs' international expansion and the moderating role of CEO origin.FindingsThis study finds that innovation aspiration shortfall has a positive impact on EEFs' international expansion. This study also uncovers that EEFs are less likely to implement international expansion in response to innovation aspiration shortfall when the CEO is a founder than when the CEO is a non-founder, and EEFs are more likely to implement international expansion in response to innovation aspiration shortfall when the CEO is an outsider-CEO than when the CEO is an insider-CEO.Originality/valueThis study proposes that the interaction between innovation aspiration shortfall and CEO origin can be a useful predictor of EEFs' international expansion.
Student-managed investment funds (SMIFs) in India: the perspectives of student fund managers
Authors: Joseph Alphil Maria , Jose Jerrin , Iyer Anusha Srinivasan 
Published: June 2022

Purpose
This paper aims to explore how the student fund managers perceive the benefits of being part of the fund. Furthermore, this paper examines the country-specific challenges of setting up and managing a student-managed investment fund (SMIF) in India.

Design/methodology/approach
Qualitative content analysis technique is used to identify, compare and retrieve critical themes about the present state of SMIF clubs in India. The data collection method involved structured, in-depth online interviews with ten student fund managers from various higher educational institutions in India.

Findings
Some of the study’s key findings indicate that the existence of SMIFs as part of learning facilitates group decision-making and peer learning. Additionally, this study brings to light specific issues related to registration, incorporating real-world practices and integrating SMIF into the academic curriculum.

Social implications
The outcomes of this study shall be of use to students and the teaching fraternity across Indian colleges and universities who aspire to set up SMIFs as part of experiential learning. This study will also help existing SMIF clubs in India understand how their counterparts work and can consequently improvise their organizational structure and functioning.

Originality/value
To the best of the authors’ knowledge, this is the first interview-based evaluation of the present structure of SMIFs structured as clubs in India.
Proactive responses to job insecurity: why and when job-insecure employees engage in political behaviors
Authors: Zhang Junwei , Zhang Yajun , Lu Lu , Zhang Lei 
Published: June 2022

PurposeDrawing upon ego depletion theory, the authors developed a serial mediation model linking job insecurity with employee political behavior in which resource depletion and moral disengagement operated as two sequential mediators. The authors further identified employee moral identity as an important boundary condition that impacts the strength of this serial mediation effect.Design/methodology/approachMultilevel analyses were utilized to test the proposed hypotheses by analyzing a sample included 306 employees nested in 71 groups.FindingsResults revealed that job insecurity induced resource depletion that activated moral disengagement, which in turn instigated political behavior. Furthermore, employee moral identity weakened this serial indirect effect. Specifically, this indirect effect was positive when moral identity was low, whereas did not present when moral identity was high.Originality/valuePrior studies have primarily concentrated on the detrimental effects of job insecurity. However, less study has investigated how individuals proactively cope with job insecurity. The authors contribute to this stream of research by exploring whether and how job insecurity facilitates employee political behavior.
Core‐shellencapsulation formulations to stabilize desiccatedBradyrhizobiumagainst high environmental temperature and humidity
Authors: Aukema Kelly G. , Wang Mian , de Souza Beatriz , O'Keane Sophie , Clipsham Maia , Wackett Lawrence P. , Aksan Alptekin 
Published: June 2022

SummaryEngineered materials to improve the shelf‐life of desiccated microbial strains are needed for cost‐effective bioaugmentation strategies. High temperatures and humidity of legume‐growing regions challenge long‐term cell stabilization at the desiccated state. A thermostable xeroprotectant core and hydrophobic water vapour barrier shell encapsulation technique was developed to protect desiccated cells from the environment. A trehalose core matrix increased the stability of desiccatedBradyrhizobiumby three orders of magnitude over 20 days at 32°C and 50% relative humidity (RH) compared to buffer alone; however, the improvement was not deemed sufficient for a shelf‐stable bioproduct. We tested common additives (skim milk, albumin, gelatin and dextran) to increase the glass transition temperature of the desiccated product to provide further stabilization. Albumin increased the glass transition temperature of the trehalose‐based core by 40°C and stabilized desiccatedBradyrhizobiumfor 4 months during storage at high temperature (32°C) and moderate humidity (50% RH) with only 1 log loss of viability. Although the albumin‐trehalose core provided exceptional protection against high temperature, it was ineffective at higher humidity conditions (75%). We therefore incorporated a paraffin shell, which protected desiccated cells against 75% RH providing proof of concept that core and shell encapsulation is an effective strategy to stabilize desiccated cells.
Audit of waiting time‐to‐treatment of atypical endometrial hyperplasia
Authors: Anderson Annabel , Cooper Juliet , Oyston Charlotte , Miles Carina , Sowden Katherine , Peiris‐John Roshini , Wise Michelle R. 
Published: June 2022

BackgroundAtypical endometrial hyperplasia (AEH) is the precursor lesion in endometrial carcinoma, the most common gynaecological malignancy in New Zealand, with inequities in disease burden and outcome for Māori and Pacific women.AimsIn women diagnosed with AEH at two hospitals, to audit five standards of care for surgical management and time‐to‐treatment, and identify variation in care by ethnicity and other factors.Materials and MethodsDemographic, referral, diagnostic and treatment characteristics were collected for women with a new AEH diagnosis between 1/1/2019 and 31/12/2020. Surgical management and time‐to‐treatment were audited against Royal College of Obstetricians and Gynaecologists and New Zealand Ministry of Health Faster Cancer Treatment recommendations.ResultsOf 124 participants, 60% were Pacific, 86% premenopausal, and 80% had obesity. For 55 women managed surgically, surgical standards of care were met. There were delays between referral, diagnosis and treatment – only 18% and 56% of women met the 62‐day (referral to treatment) and 31‐day (decision‐to‐treat to treatment) targets, respectively. Wait times were prolonged for women who had dilation and curettage (vs pipelle), magnetic resonance imaging (MRI) (vs no MRI), and surgery (vs medical management). Ethnic disparities were not identified for any standard.DiscussionDelays to treatment were found throughout women's journeys. Hospital services can streamline their clinical pathways for women referred for abnormal uterine bleeding, flagging obesity as a high suspicion for cancer indicator, increasing access to endometrial sampling in primary care and establishing ‘one‐stop‐shop’ outpatient assessment with empiric initiation of intrauterine progestogen.
Degradation influences equilibrium and non‐equilibrium dynamics in rangelands: implications in resilience and stability
Authors: López Dardo Rubén , Cavallero Laura , Willems Priscila , Bestelmeyer Brandon Thomas , Brizuela Miguel Angel 
Published: June 2022

AbstractQuestionPlant communities are structured by both equilibrium and non‐equilibrium dynamics, which interact at different spatiotemporal scales. The influence of external factors on internal regulation processes might depend on ecological state, and thus, on system resilience. We asked if well‐conserved (reference) states have higher resilience to external factors than degraded states, considering the greater capacity for self‐regulation expected of reference states.LocationGraminous–subshrubby steppes of northern Patagonia, Argentina.MethodsDuring four years, we assessed the influence of an external factor (rainfall variability) on internal regulation processes (seedling recruitment, growth of main perennial species, and three resilience proxies) in two alternative states (one reference and another degraded) of graminous–subshrubby steppes of northern Patagonia (Argentina). Specifically, we assessed the response of alternative states to simulated high rainfall events (irrigation).ResultsThe degraded state was more sensitive to rainfall variability than the reference state. Specifically, in the degraded state the density of surviving seedlings, the growth of shrubs and Papostipa speciosa’s relative tiller production and cover increased in response to irrigation; whereas seedling emergence and survival, and grass growth were low or even null without irrigation. Finally, resistance and elasticity were lower whereas malleability was greater in degraded than in reference states.ConclusionsThe degraded state was less resilient (low resistance and elasticity; high malleability) to stochastic weather events (in response to either increases or decreases in water availability. In contrast, the reference state had a great capacity to respond to rainfall variability. However, demographic processes such as seedling recruitment and vegetative growth were compensated by competition and mortality, suggesting a lower sensitivity to external drivers, and thus, a greater stability. By influencing the balance between equilibrium and non‐equilibrium dynamics, degradation might affect the resilience and stability of the ecosystem. Thus, to prevent rangeland degradation, management plans should anticipate climatically favorable and unfavorable periods.
Asciminib for chronic myeloid leukaemia: Next questions
Authors: Shanmuganathan Naranie , Hughes Timothy P. 
Published: June 2022

SummaryRecent approval of asciminib, a novel “specifically targeting the ABL myristoyl pocket” (STAMP) BCR‐ABL1 inhibitor, for the treatment of chronic myeloid leukaemia (CML) patients who have either failed ≥2 lines of therapy or have the T315I mutation, has provided clinicians with a wider selection of potentially effective treatment options. Asciminib has the attractive twin attributes of high potency directed against BCR‐ABL1 and good tolerability based on its limited off‐target effects. However, it is unclear exactly where asciminib will be positioned amongst the other available tyrosine kinase inhibitors (TKIs), especially ponatinib which is also available for the same indications. There are many questions yet to be answered with regard to the optimal use of asciminib which include its role in the first‐ and second‐line settings, combination therapy with other TKIs, and effectiveness in advanced phase CML. In this review, we discuss the available data on asciminib while exploring a number of clinical trials in progress. Finally, we provide our opinion based on the current data about where asciminib is most likely to be the optimal choice, which will hopefully assist clinicians with therapy selection.
M6A demethylase fat mass and obesity‐associated protein regulates cisplatin resistance of gastric cancer by modulating autophagy activation through ULK1
Authors: Zhang Yan , Gao Ling‐xi , Wang Wen , Zhang Teng , Dong Fang‐yi , Ding Wen‐ping 
Published: June 2022

AbstractDrug resistance is an important factor for treatment failure of gastric cancer. N6‐methyladenosine (m6A) is the predominant mRNA internal modification in eukaryotes. The roles of m6A modification in drug resistance of gastric cancer remains unclear. In the present study, the m6A methylated RNA level was significantly decreased while the expression of m6A demethylase fat mass and obesity‐associated protein (FTO) was obviously elevated in cisplatin‐resistant (SGC‐7901/DDP) gastric cancer cells. Knockdown of FTO reversed cisplatin resistance of SGC‐7901/DDP cells both in vitro and in vivo, which was attributed to the inhibition of Unc‐51‐like kinase 1 (ULK1)‐mediated autophagy. Mechanistically, ULK1 expression was regulated in an FTO‐m6A‐dependent and YTHDF2‐mediated manner. Collectively, our findings indicate that the FTO/ULK1 axis exerts crucial roles in cisplatin resistance of gastric cancer.
Reading to learn? The co‐development of mathematics and reading during primary school
Authors: Hübner Nicolas , Merrell Christine , Cramman Helen , Little John , Bolden David , Nagengast Benjamin 
Published: June 2022

AbstractUnderstanding how early reading and mathematics co‐develop is important from both theoretical and pedagogical standpoints. Previous research has provided mixed results. This paper investigates the development of reading and mathematics in a longitudinal sample of N = 355,883 students from the United Kingdom (2005–2019) aged 5 to 12 (49% girls). Results indicate a positive relation between the development of the two domains. In addition, a substantial statistically significant positive association between prior reading scores and subsequent changes in achievement in mathematics was found, whereas changes in reading were smaller for students with a higher prior performance in mathematics. The findings suggest that acquiring good reading skills is highly relevant for developing mathematics skills. Implications for theory and practice are discussed.
Toward an Account of Intuitive Time
Authors: Lee Ruth , Shardlow Jack , Hoerl Christoph , O'Connor Patrick A. , Fernandes Alison S. , McCormack Teresa 
Published: June 2022

AbstractPeople hold intuitive theories of the physical world, such as theories of matter, energy, and motion, in the sense that they have a coherent conceptual structure supporting a network of beliefs about the domain. It is not yet clear whether people can also be said to hold a shared intuitive theory of time. Yet, philosophical debates about the metaphysical nature of time often revolve around the idea that people hold one or more “common sense” assumptions about time: that there is an objective “now”; that the past, present, and future are fundamentally different in nature; and that time passes or flows. We empirically explored the question of whether people indeed share some or all of these assumptions by asking adults to what extent they agreed with a set of brief statements about time. Across two analyses, subsets of people's beliefs about time were found consistently to covary in ways that suggested stable underlying conceptual dimensions related to aspects of the “common sense” assumptions described by philosophers. However, distinct subsets of participants showed three mutually incompatible profiles of response, the most frequent of which did not closely match all of philosophers’ claims about common sense time. These exploratory studies provide a useful starting point in attempts to characterize intuitive theories of time.
Do spatial dependence and market power matter in the diversification of cooperative banks?
Authors: Algeri Carmelo , Forgione Antonio F. , Migliardo Carlo 
Published: June 2022

AbstractThis study examines the determinants of cooperative banks' diversification proclivity, with consideration of the spatial dependence effect. The empirical analysis demonstrates that Italian cooperative banks operate as a network with significant spillover effects that should not be ignored. Indeed, local banks compete in the same market segment, and any shift in their diversification strategy has a cascading effect on neighbouring cooperative banks as a result of customer migration. Finally, we observe that an increase in bank market power results in a decline in local bank lending activity.
Telepsychiatry services during COVID‐19: A cross‐sectional survey on the experiences and perspectives of young adults with first‐episode psychosis
Authors: Lal Shalini , Abdel‐Baki Amal , Lee Hajin 
Published: June 2022

AbstractIntroductionLimited evidence exists on the implementation of telepsychiatry within the context of early intervention services for psychosis, the need for which has become even more relevant during the COVID‐19 pandemic. To address this gap, we investigated the experiences and perspectives of young adults recovering from a first‐episode psychosis (FEP) following their use of telepsychiatry services (i.e. use of video conferencing technology to deliver mental health services to patients in real time).MethodsA cross‐sectional online survey study was implemented between November 19th, 2020 and March 9th, 2021 with young adults recruited from a specialized program for FEP located in an urban Canadian setting. Data were analysed using descriptive statistics, exploratory (Fisher's exact test), and content analysis.ResultsAmong 51 participants (mean age = 26.0, SD = 4.7; 56.9% female), the majority were satisfied with the service (91%, 46/51), perceived that the platform was easy to use (90%, 46/51) and felt secure in terms of confidentiality (82%, 42/51). Satisfaction was related to perceptions regarding ease of use, image quality, and employment/studying status. Several partially or totally agreed that the presence of a third party was essential to login during the first few sessions (35%, 18/51), and some needed technical support (24%, 12/51) throughout the sessions.ConclusionsThis study shows that telepsychiatry is feasible and acceptable to implement for patients in the early phase of psychosis recovery. It also highlights the importance of making technical support available, especially in the first few times of using the service, and addressing patient concerns regarding confidentiality, even when using secured health technologies.
Transcription factor YY1 contributes to human melanoma cell growth through modulating the p53 signalling pathway
Authors: Zhou Shumin , Li Pin , Qin Li , Huang Shuhong , Dang Ningning 
Published: June 2022

AbstractMelanoma has a higher mortality rate than any other skin cancer, and its cases are increasing. The transcription factor YY1 has been proven to be involved in tumour progression; however, the role of YY1 in melanoma is not well understood. This study investigates how YY1 functions in melanoma progression, and it also elucidates the underlying mechanisms involved. We have found that in clinical human melanoma tissues, YY1 is overexpressed compared with YY1 expression in normal melanocytes and skin tissues. Cellular immunofluorescence shows that YY1 is mainly located in the nucleus. YY1 knockdown reduces proliferation, migration and invasion of melanoma cell lines. Moreover, the apoptosis rate of cells is significantly increased in low‐YY1 environments. The overexpression of YY1 resulted in decreased apoptotic rates in melanoma cells. YY1 also affects the expression of EMT‐related proteins. Additional experiments reveal that YY1 knockdown disrupts the interaction of MDM2–p53, and that it both stabilizes and increases p53 activity. The upregulation of p53 expression in turn stimulates p21 expression just as it suppresses CDK4 expression, which then induces cells that were arrested in the G1 phase. The effect then is to constrain cell proliferation in melanoma cells. Upon activation of the p53 pathway, Bax, a pro‐apoptotic protein, is upregulated, and Bcl‐2, an anti‐apoptotic protein, was downregulated in A375 cells. The findings of this study provide novel insights into the pathology of melanoma as well as the role that YY1 plays in tumour progression. The findings also suggest that targeting YY1 has the potential to improve the diagnosis and treatment of melanoma.