bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE INTERPLAY BETWEEN GENETIC VARIANTS IN MIR146A AND ABCG2 GENES IS ASSOCIATED WITH HUMAN SURVIVAL
Authors: Yashin Anatoliy , Wu Deqing , Arbeev Konstantin , Duan Hongzhe , Holmes Rachel , Akushevich Igor , Ukraintseva Svetlana 
Published: January 2025

Abstract
The ABCG2 gene is well-known for its role in developing drug resistance and for its impact on the survival of cancer patients. To modulate the effects of ABCG2 on health and survival different intervention strategies were suggested. Among them, the use of non-coding RNAs that are involved in posttranscriptional modification of gene expression was suggested. MiR146a is known as a posttranscriptional regulator of expressions of many genes involved in aging, health, and survival traits. In this paper, we evaluate the role of interplay between variants in miR146a and ABCG2 genes in human survival. We apply the logistic regression model with the interaction term to the analysis of Framingham Heart Study data to test the null hypothesis that the interplay between variants in miR146a and ABCG2 genes is not associated with human survival. As an outcome we use the survival trait, Sur1, defined by dichotomizing a person’s lifespan, LS, as follows: Sur1=1, if LS &gt;=85 years; Sur1=0 if LS &lt; 85. We used the clumping procedure to reduce the number of tests and increase the Bonferroni correction threshold (BCT). The analysis detected a statistically significant association of interaction between rs13120400 in the ABCG2 gene and rs2910163 in the miR146 gene, β=-0.46. p=3.74E-03, BCT = 1.00E-02. Interactions of rs13120400 also showed nominally statistically significant associations with two other SNPs from the miR146a gene. rs2910164: β=-0.38, p=1.96E-02; and rs2961920: β=-0.36, p=2.45E-02. It turns out that all four SNPs are well known in scientific literature and play important roles in many health and longevity-related traits.
BIOPSYCHOSOCIAL DETERMINANTS OF PHYSICAL ACTIVITY IN BLACK WOMEN WITH CARDIOVASCULAR DISEASE
Authors: Kim Hyun Jung , Gore Shweta 
Published: January 2025

Abstract
Cardiovascular disease (CMD) remains the primary cause of death among Black women in the United States. Given the well-recognized benefits of physical activity (PA) in reducing CVD mortality, PA levels among Black women remain notably low. This study aims to explore factors associated with low PA in Black women with CMD via secondary analysis of subjective Global Physical Activity Questionnaire data in the 2013-2028 National Health and Nutrition Examination Survey (NHANES) sample. The prevalence of CVD among Black women (26,100,000 ± 2,171,143) in the estimated total population of United States (US) was significantly greater than in Black men (21,300,000 ± 1,592,102) (t = -5.02, p &lt; 0.001). Significantly greater proportion of Black women in the US did not meet the recommended PA guidelines (79.9% versus 89.3% in Black men and women; t = 3.51, p = 0.001). Among Black men and women, age, self-perceived health, and difficulty walking emerged as significant predictors of meeting PA guidelines (F5, 40 = 10.07, p &lt; 0.001, whereas age and high glycosylated hemoglobin (HbA1c) were significant predictors among Black women (F8, 36 = 2.62, p = 0.023). Every unit increase in age and HbA1c decreased the odds of Black women meeting the PA guidelines by 5% and 27.6% (OR = 0.96, p = 0.014 and OR = 0.96, p = 0.014).
CHARACTERIZATION OF NOVEL ACCELEROMETER-MEASURED PHYSICAL ACTIVITY METRICS BY COGNITIVE STATUS IN OLDER ADULTS
Authors: Cai Yurun , Snitz Beth , Cohen Ann 
Published: January 2025

Abstract
Although levels of physical activity (PA) are associated with risk of mild cognitive impairment (MCI) and Alzheimer’s disease (AD), most studies have used self-report PA and/or focused solely on intensities (e.g., MVPA) which may lead to recall bias or measurement error. We aim to characterize novel PA metrics among adults aged ☐50y with various cognitive status in the Connectomics in Brain Aging and Dementia study. A total of 166 (mean age 65.3☐8.9y, 65.9% women) participants with neuropsychological and valid accelerometer data in 2016-2021 were included in the analysis. PA metrics included total activity counts (TAC), logged TAC (LTAC), activity fragmentation, active minutes/day, number of active bouts, and PA complexity calculated using multiscale entropy. Participants were classified into normal control (NC)(n=84), impaired without complaints (IWOC) or subjective cognitive complaints (SCC)(n=36), and MCI/AD(n=44). Analysis of variance analysis found that IWOC/SCC had fewer number of active bouts than NC (85.34 vs. 91.83, p=0.043), lower PA complexity than NC (52.57% vs. 64.33%, p=0.001) and MCI/AD (52.57% vs. 60.68%, p=0.045). Participants with MCI/AD had lower LTAC than NC (14.38 vs. 14.50, p=0.042) and higher activity fragmentation than the other two groups (25.89% vs. 23.70%, p=0.035). Logistic regression models showed that each 1% higher in PA complexity was associated with 4% lower odds of IWOC/SCC compared to NC (OR=0.96, 95%CI:0.93-0.99, p=0.004), adjusted for sociodemographics. Our study highlights the importance of assessing novel PA metrics particularly PA complexity which may be more sensitive than conventional metrics to identify adults at early stages of pathological progression to dementia.
EFFECTS OF PHYSICAL ACTIVITY AND CVD RISK ON MEMORY CONCERNS: RESULTS FROM THE NATIONAL HEALTH INTERVIEW SURVEY
Authors: Anderson Joel , Harris Robin , Smith Jennifer 
Published: January 2025

Abstract
Common pathways exist between cardiovascular and cerebrovascular diseases in aging adults; therefore, this study examined the associations between the frequency of physical activity (PA) and memory issues in older adults with or at risk for cardiovascular disease (CVD). Data from the 2022 National Health Interview Survey were used to examine the influence of CVD risk and physical activity on self-reported experiences of memory challenges using logistic regression. The sample (N = 13,432) was limited to adults ≥50 years of age. Most of the sample was female, White, married/partnered, and reported a good to excellent health status. Roughly a quarter (24.9%) reported some difficulty remembering or concentrating while the majority (89.1%) had some level of increased CVD risk based on Framingham criteria. Half of the sample (51%) did not meet the current PA guidelines for older adults. After controlling for age, sex, race, ethnicity, and region, those with a poor or fair health status (OR = 3.24, CI = 2.94–3.56, p &lt; 0.001), increased CVD risk (OR = 1.26, CI = 1.09–1.47, p = 0.002), or who did not meet current PA guidelines (OR = 1.67, CI = 1.46–1.90, p &lt; 0.001) more frequently reported challenges with remembering or concentrating. Given these findings, further research is warranted into the role of PA in memory issues, particularly for those at risk for CVD. Following guidelines for PA for these older adults may be helpful.
FEASIBILITY AND EFFECTS OF HIGH-INTENSITY INTERVAL TRAINING ON COGNITIVE FUNCTION AND BRAIN HEALTH IN PERIMENOPAUSE
Authors: Cirone Victoria , Silva Nárlon Cássio Boa Sorte , Barha Cindy , Handy Todd , Stein Ryan , Heath Sarah , Liu-Ambrose Teresa 
Published: January 2025

Abstract
Neuroendocrine changes during perimenopause negatively impact cognitive function and brain health (e.g., reduced verbal episodic memory and myelin catabolism in the brain). Exercise promotes cognitive performance and mitigates vascular risk factors for cognitive impairment. High-intensity interval training (HIIT) involves short bursts of high-intensity exercise interspersed with active recovery; it improves cardiovascular fitness and vascular risk profile. HIIT addresses the “lack of time” barrier to exercise that perimenopausal females report. This pre-post pilot study assessed the feasibility and potential effects of 12-weeks of HIIT on cardiovascular fitness, verbal episodic memory, hippocampal volume, and myelin content. Feasibility metrics included recruitment rate (i.e., 1/month), withdrawal rate (i.e., &lt; 15%), adherence (i.e., &gt;60%). Training fidelity was assessed by cardiovascular fitness (VO2max.) Verbal episodic memory was assessed by Rey Auditory Verbal Learning Test delayed recall. Hippocampal volume was measured by T1-weighted magnetic resonance imaging. Myelin content was measured by myelin water fraction. Cohen’s d and one-tailed paired t-tests assessed effect sizes and potential changes. Recruitment rate was 0.35 participants/month (six participants in 17 months). Withdrawal rate was 16.67% and adherence was 88.2%. The intervention had a negligible effect on VO2max (Cohen’s d=0.06, p=0.35), large and significant effect on delayed recall (Cohen’s d=0.94, p=0.04), negligible effect on hippocampal volume (Cohen’s d=0.06, p=0.18), and medium to large effect on sagittal stratum myelin content (Cohen’s d=0.68, p=0.06). Future studies should consider home-based exercise and tailored recruitment methods (e.g. social media) to meet recruitment targets. HIIT may be beneficial for cognitive function and myelin content.
FEASIBILITY OF A REMOTE SOCIAL NETWORK-BASED OCCUPATIONAL THERAPY PHYSICAL ACTIVITY INTERVENTION
Authors: Webster Noah , Santioni Margaret , Petroff Lisa , Adnan Maham , McGuire Katrina , Alexander Neil 
Published: January 2025

Abstract
Despite physical activity being associated with personal and societal benefits, only 16 percent of people age 65 and older engage in recommended levels. To assist in increasing this percentage, we developed a six-week social network-based occupational therapy intervention to be administered remotely with older adults living in subsidized housing. The intervention was designed to improve physical activity through incorporation of socially engaged residents as advisory committee members and addressing activity barriers such as pain through group and individual meetings with an occupational therapist. In summer/fall 2023 a pilot feasibility study was conducted with a cohort of older adults (n=5) living in a Southeast, Michigan housing community. Process outcomes were examined and secondary health and activity outcomes were assessed via pre- and post-intervention interviews and accelerometry. Participants attended on average 9.2 (SD=1.3) intervention activities out of 10. None of the participants knew each other prior to intervention enrollment. However, post-intervention, four of the five participants reported knowing three or more other participants. In terms of secondary outcomes, three out of five participants reported a decline in the extent to which pain interfered with activities and perceived barriers to physical activity decreased for two participants, increased for two, and stayed the same for one. Step counts increased for two participants, but decreased for three. Secondary outcomes were mixed and suggest needed modifications. Additionally, while participation rates exceeded expectations, feasibility was not supported for the social network approach. However, newly formed social ties resulting from the intervention highlight potential for future behavior change.
GENETIC RISK, MODIFIABLE FACTORS, AND COGNITIVE PERFORMANCE IN MIDDLE- AND OLDER-AGED CANADIANS
Authors: Hopper Shawna , Barha Cindy , DeMarco Mari , Cosco Theodore , Wister Andrew , Best John 
Published: January 2025

Abstract
Whether the apolipoprotein E (APOE) e4 allele interacts with modifiable factors to predict cognitive performance is unclear. This study examined 26,448 participants (45 to 86 years of age at baseline) in the Canadian Longitudinal Study on Aging who had their blood genotyped for the APOE e4 allele, of whom 6,305 (24%) were e4 carriers. Cognitive outcomes were Rey Auditory Verbal Learning Test 5-minute delayed recall, Mental Alterations Test, and Animal Fluency Test, which were collected at baseline (December 2011 to July 2015), follow-up 1 (median 2.9 years after baseline), and follow-up 2 (median 5.8 years after baseline). We examined interactions between time from baseline, APOE e4 status and the following exposures: self-reported physical activity and a composite risk score comprised of sedentary behavior, smoking, depressive symptoms, social isolation, whole blood hemoglobin A1c fraction, and percent body fat. Models were adjusted for age, sex, ethnicity, study language (French/English), residential setting (urban/rural), and educational attainment. Across cognitive outcomes, an age by APOE e4 interaction was observed (p values ranging from &lt;.001 to.01), such that the difference in cognitive performance between carriers and non-carriers increased as participant age increased. Although physical activity and composite risk were associated with cognitive performance (all p values &lt;.01), there was not convincing evidence that these associations varied by e4 carrier status after correcting for multiple comparisons. Together, these findings confirm that APOE e4 carriers show greater reductions in cognitive performance but do not suggest that e4 status alters associations between modifiable risk and cognitive decline.
LEISURE ACTIVITY AND POSITIVE MOOD ACROSS ADULTHOOD: RESULTS FROM THE KOREAN TIME USE SURVEY
Authors: Cha Seung-Eun , Kim Kyungmin , Kim Hyejoong 
Published: January 2025

Abstract
Adults in middle and later life may look forward to dedicating more time to outdoor leisure activities, which can contribute to their health and well-being. This study utilized 2-day time diaries from the 2019 Korean Time Use Survey (respondent N = 22,821; age 20−84) to examine how Korean adults engage in various outdoor activities (e.g., social visits, attending cultural events, and exercising) and whether their activity engagement (indicated by outdoor activity diversity and total hours of outdoor activity) is associated with positive mood. Further, we investigated whether these associations varied by age groups (age 20–39, 40–64, and 65–84), considering differences in family and work demands. We accounted for respondents’ total TV viewing hours, total “doing-nothing” hours, and sociodemographic characteristics as control variables in the models for positive mood. The findings showed that total hours of outdoor activities and watching TV were positively associated with a positive mood in younger adults, supporting the psychological benefits of detachment from work. Yet, for older individuals, diversity in outdoor activities was positively associated with positive mood, while total hours of outdoor activities were not significant—which indicates that engaging in various activities throughout the day can be beneficial for psychological well-being in later life. Notably, we found that total TV viewing hours were negatively associated with the positive mood of older adults. This study sheds light on the differential impacts of leisure activities based on life stages, underscoring the importance of diverse leisure activities for the psychological health of older individuals.
MAPPING THE LITERATURE FOR THE PHYSICAL ACTIVITY SCALE FOR THE ELDERLY (PASE): A SCOPING REVIEW
Authors: D’Amore Cassandra , Lajambe Lexie , Bush Noah , Hiltz Sydney , Laforest Justin , Viel Isabella , Hao Qiukui , Beauchamp Marla 
Published: January 2025

Abstract
The Physical Activity Scale for the Elderly (PASE) is a commonly used and recommended self-report measure of physical activity in older adults. This scoping review aimed to map the nature and extent to which the PASE has been used in community-dwelling older adults, including the evidence for its psychometric properties. Review eligibility criteria included: i)community-dwelling older adults (60+ years), ii)physical activity integrated into study aims and measured with the PASE, and iii)published in English. Pairs of independent reviewers screened abstracts, full-texts, and extracted data. Where possible, weighted mean PASE scores were calculated for subgroups based on age, sex, and clinical population. Seven electronic databases were searched in January 2023; 4,124 studies were screened, and 232 articles from 35 countries were included. Most studies were completed in high-income countries (86.4%) and North America (49.57%). A variety of clinical conditions were included (n=21), the most common populations being osteoarthritis (n=13), Parkinson’s disease (n=11), and cognitive impairment (n=7). Psychometric properties for ten versions of the PASE were reported. All versions demonstrated acceptable test-retest reliability. Evidence for construct validity reported moderate correlations with self-reported physical activity and fair to moderate correlations with accelerometry-derived activity. Pooled means were reported in graphs and forest plots by age, sex, and clinical populations. The PASE was widely used across geographical locations and culturally adapted to several populations. Some psychometric properties have been evaluated; however, further research is required to examine responsiveness and predictive validity. The weighted mean PASE scores presented can improve interpretability of scores in similar populations.
PHYSICAL ACTIVITY AND EXERCISE-INDUCED NEUROTROPHIC AND CORTISOL RESPONSES: PRELIMINARY RESULTS
Authors: Huynh Thinh , Rushing Baylie , Love Madeleine , Head Denise , Stojanovic Marta 
Published: January 2025

Abstract
Neurotrophic and cortisol responses to a bout of exercise are a pathway for understanding the potential mechanisms underlying the beneficial effects of regular physical activity on cognitive and brain health. However, there is limited understanding of the factors that moderate such responses. This study examined whether long-term exercise history and current moderate-to-vigorous physical activity (MVPA) levels predicted neurotrophic and cortisol responses to acute exercise. In addition, we investigated whether these associations were moderated by age and sex. Clinically normal middle-aged and older adults from the Knight ADRC Adult Children Study (n=54; age=43-85) completed a questionnaire about exercise engagement over a 10-year period and underwent a submaximal VO2 assessment, with both representing a combined estimate of their long-term physical activity. Participants also completed seven days of actigraphy, which was used to estimate current MVPA. Participants engaged in a bout of exercise, with neurotrophic factors and cortisol measured at baseline, 10 minutes post-exercise, and 30 minutes post-exercise. Long-term physical activity did not influence neurotrophic (p=0.538) or cortisol responses (p=0.276), regardless of age and sex (p’s &gt;0.143). Higher current MVPA was associated with a greater neurotrophic response (p=0.007) across sex (p=0.165). Additionally, there was a moderation by age (p=0.014), with less of an association as age increased. Greater current MVPA was also associated with a smaller cortisol response (p=0.044), across age and sex (p’s&gt;0.144). These results suggest that current MVPA may be particularly important when considering pathways between a single bout of exercise and neurocognitive health.
PHYSICAL ACTIVITY FRAGMENTATION AND FALLS IN OLDER ADULTS
Authors: Popelsky Braden , Gabriel Kelley Pettee , Dooley Erin , Ylitalo Kelly 
Published: January 2025

Abstract
Physical activity (PA) may be an important fall prevention strategy. Current PA guidelines emphasize total PA dose, but daily patterning of PA is underappreciated. With aging, PA bouts become less frequent and shorter in duration (i.e., more fragmented). PA fragmentation may be an indicator of fall risk, but the relationship is not well understood. This study examined daily PA patterns and fall risk in a sample of older adults from the National Health and Aging Trends Study (NHATS; (n=685, 54.3% female, 61.5% aged 70–79 years). Wrist-worn accelerometry from Round 11 (2021) measured PA and surveys from Round 12 (2022) measured falls. PA variables were categorized into tertiles and incident falls were defined as ≥1 self-reported fall in the year following the PA assessment. A modified Poisson approach was used to estimate the relative risk of total PA and PA fragmentation with falls. Overall, 40.0% reported ≥1 incident fall. After adjustment for sociodemographic and health characteristics, those in the highest tertile of total PA accumulation had lower fall risk (aRR=0.74; 95% CI: 0.57, 0.95) and those in the highest tertile of PA fragmentation had increased fall risk (aRR=1.33; 95% CI: 1.02, 1.74) compared to those in the lowest tertiles, respectively. Models were attenuated after the adjustment for physical functioning. PA fragmentation may identify fall risk in older adults. More work is needed to understand the complex relationship between PA and physical functioning across the life-course.
RUNNING, HEALTHY AGING, AND SOCIOCULTURAL CHANGE OVER 50 YEARS: PERSPECTIVES FROM OLDER ADULTS
Authors: Hurtt Barbekka , Hudes Seth , Deters Shana , Allen Josie , Cutforth Asia , Hasche Leslie 
Published: January 2025

Abstract
Running is a relatively easily accessible and perceived low barrier to entry sport for any age. This project goal was to understand how running is conceptualized as part of healthy aging over the past 50 years, given sociocultural and demographic changes that have occurred. Through recruitment on social media, with running groups, and at marathon events, participants completed survey and interview data on their life course experiences with running. Out of 37 survey participants, 5 were aged 61 or older with an average age 71 years old; of 21 interview participants, 5 were aged 61 or older. Survey results indicated that running was perceived as contributing to: a) positive increases in physical health attributes such as bone, cardiovascular, and immune health, muscle strength, and metabolism; and b) slightly or significantly more positive mood; conversely, all participants indicated their mood worsened when taking time off from running. Interview data supported the survey data and revealed positive perspectives of older athletes through phrases such as “motivating, strong, badass, happy, healthy, cool, active;” conversely, the majority of respondents felt “angry, upset, or frustrated” at the phrase “You play/run like an old person.” Slightly more than 50% of participants desired improvement for older adult community athletic opportunities, particularly those related to running. Yet, most older adult participants agreed that they “feel comfortable in my community to achieve my full athletic potential.” Community leaders, health, and aging services should consider opportunities to promote running groups for older adults that support both new and experienced runners.