bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuation and maintenance therapy in depression
Authors: Paykel E S 
Published: July 2002

AbstractThis paper reviews longer term treatment for unipolar depression. Antidepressant continuation for prevention of early relapse has been routine for many years. Recent evidence supports a longer period of 9 months to 1 year after remission. Antidepressants are also effective in maintenance treatment for recurrent depression, and are indicated where there is clear risk of further episodes. Antidepressant withdrawal after continuation and maintenance should always be gradual, over a minimum of 3 months and longer after longer maintenance periods, to avoid withdrawal symptoms or rebound relapse. Trials of interpersonal therapy in the prevention of recurrence show some benefit, but effects are weaker than those of drug and additional benefit in combination is limited. There is better evidence for effects of cognitive therapy in preventing relapse and an emerging indication for its addition to antidepressants, particularly where residual symptoms are present.
Association of Maternal Preeclampsia With Offspring Risks of Ischemic Heart Disease and Stroke in Nordic Countries
Authors: Yang Fen , Janszky Imre , Gissler Mika , Roos Nathalie , Wikström Anna-Karin , Yu Yongfu , Chen Hua , Bonamy Anna-Karin Edstedt , Li Jiong , László Krisztina D. 
Published: November 2022

ImportanceAn association between maternal preeclampsia and an increased risk of cardiovascular disease in the offspring is plausible, but evidence in this area is limited.ObjectiveTo investigate (1) the association between maternal preeclampsia and risks of ischemic heart disease (IHD) and stroke in the offspring, (2) whether the association varies by severity or timing of onset of preeclampsia, and (3) the role of preterm birth and small for gestational age (SGA) birth, both of which are related to preeclampsia and cardiovascular diseases, in this association.Design, Setting, and ParticipantsThis multinational population-based cohort study obtained data from Danish, Finnish, and Swedish national registries. Live singleton births from Denmark (1973-2016), Finland (1987-2014), and Sweden (1973-2014) were followed up until December 31, 2016, in Denmark and December 31, 2014, in Finland and Sweden. Data analyses were performed between September 2020 and September 2022.ExposuresPreeclampsia and its subtypes, including early onset (&amp;lt;34 gestational weeks) and late onset (≥34 gestational weeks), severe and mild or moderate, and with and without SGA birth.Main Outcomes and MeasuresDiagnoses of IHD and stroke were extracted from patient and cause-of-death registers. Cox proportional hazards regression models and flexible parametric survival models were used to analyze the associations. Sibling analyses were conducted to control for unmeasured familial factors.ResultsThe cohort included of 8 475 819 births (2 668 697 [31.5%] from Denmark, 1 636 116 [19.3%] from Finland, and 4 171 006 [49.2%] from Sweden, comprising 4 350 546 boys [51.3%]). Of these offspring, 188 670 (2.2%) were exposed to maternal preeclampsia, 7446 (0.1%) were diagnosed with IHD, and 10 918 (0.1%) were diagnosed with stroke during the median (IQR) follow-up of 19.3 (9.0-28.1) years. Offspring of individuals with preeclampsia had increased risks of IHD (adjusted hazard ratio [HR], 1.33; 95% CI, 1.12-1.58) and stroke (adjusted HR, 1.34; 95% CI, 1.17-1.52). These associations were largely independent of preterm or SGA birth. Severe forms of preeclampsia were associated with a higher stroke risk than less severe forms (severe vs mild or moderate: adjusted HR, 1.81 [95% CI, 1.41-2.32] vs 1.22 [95% CI, 1.05-1.42]; early vs late onset: adjusted HR, 2.55 [95% CI, 1.97-3.28] vs 1.18 [95% CI, 1.01-1.39]; with vs without SGA birth: adjusted HR, 1.84 [95% CI, 1.44-2.34] vs 1.25 [95% CI, 1.07-1.48]). Sibling analyses suggested that the associations were partially explained by unmeasured familial factors.Conclusions and RelevanceResults of this study suggest that offspring born to individuals with preeclampsia had increased IHD and stroke risk that were not fully explained by preterm or SGA birth, and that the associated risks for stroke were higher for severe forms of preeclampsia.
Effect of source location on contaminant dispersion pattern and occupants inhaled air quality in lecture room under displacement ventilation
Authors: Essa Aya , Yamanaka Toshio , Kobayashi Tomohiro , Choi Narae 
Published: November 2022

AbstractDisplacement ventilation (DV) is considered an energy saving air conditioning system and is especially recommended for classrooms for providing cool clean air in the occupied zone. However, in the current pandemic situation, ventilation systems should be assessed in terms of infection‐spread prevention as well. Hence, this study aims at assessing the efficiency of displacement ventilation in minimizing infection spread in lecture halls through investigating the effect of source position on the contaminant concentration distribution. The settings of a mid‐size DV lecture hall in Osaka University, Japan was chosen as a case‐study. Ten single‐contaminant‐source cases were simulated using CFD software. The cases were analyzed in terms of temperature distribution, contaminant diffusion pattern and vertical distribution, and breathing air quality using indices, such as local air quality index and scale of ventilation efficiency. The results demonstrated a considerable variation between cases in terms of contaminant distribution pattern, number of occupants affected, average inhaled‐air quality, and diffusion radius. Accordingly, given the ventilation system design, best and worst case‐scenarios were pointed out and factors affecting the variation were highlighted and further investigated to conclude the impact of each factor.
Trade‐Off between Second‐ and Third‐Order Nonlinearities, Ultrafast Free Carrier Absorption and Material Damage in Silicon Nanoparticles
Authors: Rudenko Anton , Han Aoxue , Moloney Jerome V. 
Published: November 2022

AbstractReaching the optimal second‐ and third‐order nonlinear conversion efficiencies while avoiding undesirable free carrier absorption losses and material damage in ultrashort laser‐excited nanostructures is a challenging obstacle in all‐dielectric ultrafast nanophotonics. In order to elucidate the main aspects of this problem, a multi‐physical model is developed, coupling nonlinear Maxwell equations supplied by surface and bulk nonlinearities with free carrier hydrodynamic equations for electron–hole plasma kinetics and electron‐ion transfer for silicon. The maximum feasible efficiencies for a single spherical particle supporting different electric and magnetic resonances are compared, and the harmonic yields are further optimized by tuning lattice resonances in a periodic arrangement of nanoparticles. Results support the dominant role of magnetic dipole and quadrupole contributions in the enhancement of the third harmonic and the electric dipole for the second harmonic, as well as the possibility to further improve the conversion of both harmonics simultaneously at least by two orders of magnitude by designing properly the resonant metasurface.
All‐Optical Digital Logic Based on Unidirectional Modes
Authors: Xu Jie , Luo Yamei , Xiao Sanshui , Kang Fengwen , Tsakmakidis Kosmas L. 
Published: November 2022

AbstractStandard electronic computing based on nanoelectronics and logic gates has upended our lives in a profound way. However, suffering from, both, Moore's law and Joule's law, further development of logic devices based solely on electricity has gradually stuck in the mire. All‐optical logic devices are believed to be a potential solution for such a problem. This work proposes an all‐optical digital logical system (AODLS) based on unidirectional (one‐way propagation) modes in the microwave regime. In a Y‐shaped module of the AODLS, the basic seven logic gates, including OR, AND, NOT, NOR, NAND, XOR, and XNOR gates, are achieved for continuous broadband operation relying on the existence of unidirectional electromagnetic signals. Extremely large extinction and contrast ratios are found in these logic gates. The idea of “negative logic” is used in designing the AODLS. Moreover, the authors further demonstrate that the AODLS can be assembled to multi‐input and/or multi‐output logical functionalities, which is promising for parallel computation. Besides, numerical simulations perfectly fit with and corroborate the theoretical analyses presented here. The low‐loss, broadband, and robust characteristics of this system are outlined and studied in some detail. The AODLS consisting of unidirectional structures may open a new route for all‐optical calculation and integrated optical circuits.
A Group Recommendation Algorithm Based on Dividing Subgroup
Authors: Jia Junjie , Chen Si , Shang Tianyue 
Published: November 2022

AbstractWith the rapid development of Internet technology and social networks, traditional personalized recommendation systems have been unable to provide effective recommendation services for groups composed of multiple users. In order to content the needs of group users, the current group recommendation algorithm mainly uses users’ consensus preferences instead of personal preferences for group recommendation, which can only content the preferences of most users and ignore the preferences of a few cold users. In order to improve the fairness of group recommendation, a group recommendation algorithm based on dividing subgroups is proposed. The algorithm introduces the comprehensive trust between users to divide the group into different subgroups, and obtains the initial subgroup recommendation list according to the average strategy. The PageRank idea is used to set the weight of subgroups and assign the number of recommended items to subgroups to generate the group recommendation list. The experimental results show that the algorithm in this paper can content the user's personalized recommendation needs to the greatest extent under the premise of improving the group fair recommendation service.
A New In Situ Prepared MOF‐Natural Polymer Composite Electrolyte for Solid Lithium Metal Batteries with Superior High‐ Rate Capability and Long‐Term Cycling Stability at Ultrahigh Current Density
Authors: Guan Jiazhu , Feng Xinping , zeng Qinghui , Li Zhenfeng , Liu Yu , Chen Anqi , Wang Honghao , Cui Wei , Liu Wei , Zhang Liaoyun 
Published: November 2022

AbstractLithium metal batteries hold promise for energy storage applications but suffer from uncontrolled lithium dendrites. In this study, a new composite membrane based on modified natural polymer and ZIF‐67 is designed and prepared by the in situ composite method for the first time. Among them, a modified natural polymer composed of lithium alginate (LA) and polyacrylamide (PAM) can be obtained by electrospinning. Importantly, the polar functional groups of natural polymers can interact by hydrogen bonding and MOFs can construct lithium‐ion transport channels. Consequently, compared with LA‐PAM electrolyte without MOF, the electrochemical stability window of ZIF‐67‐LA‐PAM electrolyte becomes wider from 4.5 to 5.2 V, and the lithium‐ion transference number (tLi+) enhances from 0.326 to 0.627 at 30°C. It is worth noting that the symmetric cells with ZIF‐67‐LA‐PAM have superior stable cycling performance at 40 and 100 mA cm−2, and a high rate at 10C and 20C for LFP cells. Besides, the cell with NCM811 high‐voltage cathode can run stably for 400 cycles with an initial discharge capacity of 136.1 mAh g−1 at 0.5C. This work provides an effective method for designing and preparing MOF‐natural polymer composite electrolytes and exhibits an excellent application prospect in high‐energy‐density lithium metal batteries.
Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia
Authors: Whiteside David J. , Malpetti Maura , Jones P. Simon , Ghosh Boyd C. P. , Coyle‐Gilchrist Ian , van Swieten John C. , Seelaar Harro , Jiskoot Lize , Borroni Barbara , Sanchez‐Valle Raquel , Moreno Fermin , Laforce Robert , Graff Caroline , Synofzik Matthis , Galimberti Daniela , Masellis Mario , Tartaglia Maria Carmela , Finger Elizabeth , Vandenberghe Rik , de Mendonça Alexandre , Tagliavini Fabrizio , Butler Chris R. , Santana Isabel , Ber Isabelle Le , Gerhard Alexander , Ducharme Simon , Levin Johannes , Danek Adrian , Otto Markus , Sorbi Sandro , Pasquier Florence , Bouzigues Arabella , Russell Lucy L. , Rohrer Jonathan D. , Rowe James B. , Rittman Timothy ,   The GENFI consortium
Published: November 2022

AbstractIntroductionWe tested whether changes in functional networks predict cognitive decline and conversion from the presymptomatic prodrome to symptomatic disease in familial frontotemporal dementia (FTD).MethodsFor hypothesis generation, 36 participants with behavioral variant FTD (bvFTD) and 34 controls were recruited from one site. For hypothesis testing, we studied 198 symptomatic FTD mutation carriers, 341 presymptomatic mutation carriers, and 329 family members without mutations. We compared functional network dynamics between groups, with clinical severity and with longitudinal clinical progression.ResultsWe identified a characteristic pattern of dynamic network changes in FTD, which correlated with neuropsychological impairment. Among presymptomatic mutation carriers, this pattern of network dynamics was found to a greater extent in those who subsequently converted to the symptomatic phase. Baseline network dynamic changes predicted future cognitive decline in symptomatic participants and older presymptomatic participants.DiscussionDynamic network abnormalities in FTD predict cognitive decline and symptomatic conversion.Highlights
We investigated brain network predictors of dementia symptom onset
Frontotemporal dementia results in characteristic dynamic network patterns
Alterations in network dynamics are associated with neuropsychological impairment
Network dynamic changes predict symptomatic conversion in presymptomatic carriers
Network dynamic changes are associated with longitudinal cognitive decline
Supercritical CO2‐assisted extrusion foaming: A suitable process to produce very lightweight acrylic polymer micro foams
Authors: Haurat Margaux , Sauceau Martial , Baillon Fabien , Barbenchon Louise Le , Pedros Matthieu , Dumon Michel 
Published: November 2022

AbstractA strategy of CO2‐assisted extrusion foaming of PMMA‐based materials was established to minimize both foam density and porosities dimension. First a highly CO2‐philic block copolymer (MAM: PMMA‐PBA‐PMMA) was added in PMMA in order to improve CO2 saturation before foaming. Then the extruding conditions were optimized to maximize CO2 uptake and prevent coalescence. The extruding temperature reduction led to an increase of pressure in the barrel, favorable to cell size reduction. With the combination of material formulation and extruding strategy, very lightweight homogeneous foams with small porosities have been produced. Lightest PMMA micro foams (ρ = 0.06 g cm−3) are demonstrated with 7 wt% CO2 at 130°C and lightest blend micro foams (ρ = 0.04 g cm−3) are obtained at lower temperature (110°C, 7.7 wt% CO2). If MAM allows a reduction of Tfoaming, it also allows a much better cell homogeneity, an increase in cell density (e.g., from 3.6 107 cells cm−3 to 2 to 6 108 cells cm−3) and an overall decrease in cell size (from 100 to 40 μm). These acrylic foams produced through scCO2‐assisted extrusion has a much lower density than those ever produced in batch (ρ ≥ 0.2 g cm−3).
Microstructural tuning and band gap engineering of calcium hydroxides: a novel approach by pH variation
Authors: Akash  , Harish  , Kumar Vipin , Mishra Rajneesh Kumar , Gwag Jin Seog , Singhal Rahul , Mukhopadhyay Anoop Kumar , Kumar Pushpendra 
Published: November 2022

AbstractHere we report a simple, inexpensive, energy benign, yet novel pH‐driven chemical precipitation technique to achieve microstructural and band gap engineering of calcium hydroxide nanoparticles (CHNPs). The chemical precipitation route involved the use of 0.4–1.6 M Ca(NO3)2.4H2O solutions as the precursor and 1 M NaOH solution as the precipitator. The simple variation in precursor molarity induces a pH change from about 12.4 to 11.3 in the reactant solution. The CHNPs characterized by X‐ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and ultraviolet–visible (UV–Vis) spectroscopy techniques confirm a jump of nanocrystallite size from ~50–70 nm with a concomitant reduction of direct optical band gap energy from ~5.38–5.26 eV. The possible mechanisms that could be operative behind obtaining microstructurally tuned (MT)‐CHNPS and band gap engineering (BGE) are discussed from both theoretical and physical process perspectives. Furthermore, the implications of these novel results for possible futuristic applications are briefly hinted upon.
Identifying determinants of refurbished apparel adoption: An attribution theory perspective
Authors: Sharma Himanshu 
Published: November 2022

AbstractEnvironmental pollution is wreaking havoc on countries all over the world today. Environmental issues are compelling governments, businesses, and consumers to collaborate to mitigate environmental damage. The concept of remanufacturing or refurbishing products has recently gained popularity. This study attempted to identify the determinants of intention to adopt refurbished apparel (IARA). Attribution Theory classified the set of independent variables into two categories namely intrinsic (customer behavior, customer value, and green awareness) and extrinsic (government policies, technological advancements, and reverse logistics). An econometric model was proposed to validate the association between the dependent variable (IARA) and these independent variables. Logistic regression is applied to a survey‐based dataset of 210 respondents. The findings significantly validate the association of internal and external variables with IARA. In addition, it was inferred that the internal variables have greater impact than the external variables.
In‐Plate Chemical Synthesis of Isopeptide‐Linked SUMOylated Peptide Fluorescence Polarization Reagents for High‐Throughput Screening of SENP Preferences
Authors: Huppelschoten Yara , Mukhopadhyay Rishov , Buchardt Jens , Nielsen Thomas E. , Vertegaal Alfred C. O. , Ovaa Huib , van der Heden van Noort Gerbrand J. 
Published: November 2022

AbstractSmall ubiquitin‐like modifiers (SUMOs) are conjugated to protein substrates in cells to regulate their function. The attachment of SUMO family members SUMO1‐3 to substrate proteins is reversed by specific isopeptidases called SENPs (sentrin‐specific protease). Whereas SENPs are SUMO‐isoform or linkage type specific, comprehensive analysis is missing. Furthermore, the underlying mechanism of SENP linkage specificity remains unclear. We present a high‐throughput synthesis of 83 isopeptide‐linked SUMO‐based fluorescence polarization reagents to study enzyme preferences. The assay reagents were synthesized via a native chemical ligation‐desulfurization protocol between 11‐mer peptides containing a γ‐thiolysine and a SUMO3 thioester. Subsequently, five recombinantly expressed SENPs were screened using these assay reagents to reveal their deconjugation activity and substrate preferences. In general, we observed that SENP1 is the most active and nonselective SENP while SENP6 and SENP7 show the least activity. Furthermore, SENPs differentially process peptides derived from SUMO1‐3, who form a minimalistic representation of diSUMO chains. To validate our findings, five distinct isopeptide‐linked diSUMO chains were chemically synthesized and proteolysis was monitored using a gel‐based read‐out.
Long‐term (>5‐year) survivors among unresectable or metastatic cancer patients treated with zoledronate‐activated killer cells: Seven case reports
Authors: Yamaguchi Yoshiyuki 
Published: November 2022

AbstractWe are conducting an adoptive immunotherapy (AIT) trial using zoledronate‐activated killer cells for patients in Japan with incurable cancer. We have encountered seven long‐term survivors. Since such long survival may be very rare in cancer treatment, we present the details and a discussion of a possible role of AIT.
Do coronary stents suffer long‐term deterioration after repeated intracoronary lithotripsy for rebel underexpansion treatment?
Authors: Valencia Jose , Herrero‐Brocal Marta , Torres‐Mezcua Fernando , Pineda Javier , Ruiz‐Nodar Juan Miguel 
Published: November 2022

AbstractCoronary intravascular lithotripsy (IVL) is the latest developed technique available for stent underexpansion treatment, although it is unclear if this therapy causes stent structure damage. We present the case of a patient with severe, refractory stent underexpansion after primary angioplasty, which was resolved with a double session of IVL. Elective angiographic and optical coherence tomography (OCT) follow‐up was performed 1 year after the procedure, which demonstrated the absence of any damage in the stent platform. Paradoxically, the study revealed a critical restenotic lesion in an area distant from the one of interest. Review of the first OCT after the primary procedure revealed 78% underexpansion in that area, which went by unnoticed and could be the cause of restenosis. Repeated IVL therapy may be helpful in cases of rebel stent underexpansion, and it conveys the impression of being safe in the long term in relation to the integrity and effectiveness of the drug‐eluting coronary stents.
Testing for equality between conditional copulas given discretized conditioning events
Authors: Derumigny Alexis , Fermanian Jean‐David , Min Aleksey 
Published: November 2022

AbstractSeveral procedures have been recently proposed to test the simplifying assumption for conditional copulas. Instead of considering pointwise conditioning events, we study the constancy of the conditional dependence structure when some covariates belong to general Borel conditioning subsets. We introduce several test statistics based on the equality of conditional Kendall's taus and derive their asymptotic distributions under the null hypothesis. In settings where such conditioning events are not fixed ex ante, we propose a data‐driven procedure to recursively build such relevant subsets. This procedure is based on decision trees that maximize the differences between the conditional Kendall's taus, which correspond to the leaves of the trees. Empirical results for such tests are illustrated in the Supplementary Material. Moreover, a study of the conditional dependence between financial stock returns is presented and highlights specific contagion effects of past returns. The last application deals with conditional dependence between coverage amounts in an insurance dataset.