bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of e-catalogue drug prices in the era of Universal Health Coverage in the Indonesian pharmaceutical industry
Authors: Satibi Satibi , Kirana P Luthfi Kinanthi , Aziza P Mella , Hutasoit Monica , Pribadi Prasojo 
Published: June 2022

Context: Since the implementation of the Universal Health Coverage (UHC) policy in Indonesia, the drug procurement system has changed to using the e-catalogue system. The impact of this policy change on the pharmaceutical industry in Indonesia is unclear and has not been widely studied.
Objectives: This study analyzes the impact of the UHC policy on drug pricing by the pharmaceutical industry in Indonesia.
Methods: This study collects data from 3 pharmaceutical industries that won the e-catalogue drug tender. Data on drug prices produced by these 3 industries in 2013 were taken from the Drug Price Ceiling List, while drug prices in 2015 and 2018 were obtained from the e-catalogue drug list. The drug price data is compared from year to year to see the trend of change and the magnitude of the change. Data were analyzed using a price index calculation adapted from the concept of Median Price Ratio (MRP) calculation to compare drug prices in 2013 with drug prices per each region in 2015 and 2018 in the Microsoft Excel Office application as a measuring tool.
Results: There was a change in drug prices from the era before UHC (in 2013) and after the UHC era (in 2015 and 2018). There are drugs that have increased in price and some have decreased in price. The price increase ranged from 0.01–6.15 in 2015 and 0.01–6.46 in 2018. The price decrease ranged between 0.04–0.75 in 2015 and 0.01–0.83 in 2018.
Conclusion: Drug prices from before the UHC era (2013 and 2015) to after UHC (in 2018) experienced a change in the form of an increase or decrease in price.
Childhood aplastic anaemia with paroxysmal nocturnal haemoglobinuria clones: A retrospective single-centre study in South Africa
Authors: Hendricks Candice L. , Naidoo Ashen , Thejpal Rajendra , Rapiti Nadine , Neethling Beverley , Goga Yasmin , Buldeo Suvarna 
Published: June 2022

Background: Paroxysmal nocturnal haemoglobinuria (PNH) clones in children are rare but commonly associated with aplastic anaemia (AA) and myelodysplasia.Objective: This study aimed to determine the prevalence of PNH clones in paediatric patients with idiopathic AA, identify differences in clinical and laboratory features and outcomes, and determine the impact of clone size on clinical presentation.Methods: Patients with confirmed idiopathic AA who were tested for PNH between September 2013 and January 2018 at the Inkosi Albert Luthuli Central Hospital, Durban, KwaZulu-Natal, South Africa, were included. PNH clones were detected in neutrophils and monocytes by flow cytometry using fluorescent aerolysin, CD24, CD66b and CD14.Results: Twenty-nine children with AA were identified and 11 were excluded. Ten patients (10/18, 55.6%) had PNH clones ranging from 0.11% to 24%. Compared to the PNH-negative group, these children were older (median: 10 years vs 4 years, p = 0.02) and had significantly lower total white cell counts (median 1.7 × 109/L vs 3.2 × 109/L; p = 0.04). There was no difference in median absolute neutrophil count or haemoglobin concentration. Four patients in each group received immunosuppressive therapy (IST). At six months, all four patients with PNH clones had responded, compared to one in the PNH-negative group.Conclusion: More than half of children with AA had a PNH clone. The size of the clone did not impact clinical severity; however, IST use may positively impact prognosis. We recommend early initiation of IST in patients with AA to avoid delays associated with human leukocyte antigen typing.
The matrix of linguistic exclusions impeding career construction for D/deaf learners
Authors: Stemela-Zali Unati , Kathard Harsha , Sefotho Maximus M. 
Published: June 2022

Background: The purpose of this study was to explore how D/deaf learners in the Eastern Cape Province of South Africa constructed their careers and what types of support were available for them to do so. The study found that among the support required, support for their linguistic development, and particularly sign language acquisition, was critical in home, school and community contexts.Objectives: The objective of this paper is to highlight the multiple linguistic exclusions faced by D/deaf learners in the Eastern Cape, which negatively impact their career construction.Method: Savickas theory of career construction framed this analytical-qualitative case study. The study was conducted in two out of four schools for the D/deaf in two districts of the Eastern Cape, South Africa. Data was gathered via four participant groups viz. Deaf learners, their parents, teachers and officials of the Department of Basic Education, as well as through documents reviews.Results: The results indicated that multiple linguistic exclusions for these learners begin early in their lives and continue into their school years and beyond. These experiences at home, school and in social contexts combined, impact negatively the process of career construction and its prospects.Conclusion: The study concluded that linguistic exclusions are exposed by the study are created by a combination of systemic factors which impede the career construction of d/Deaf learners. Implications and suggestions for advancing their linguistic inclusion are discussed.
Factors associated with smoking and transitioning to nyaope injection amongst women in the City of Tshwane Municipality: A self-report by women
Authors: Lefoka Moganki H. , Netangaheni Robert T. 
Published: June 2022

Background: Substance use disorder has emerged as a key health and social challenge in South Africa (SA). It is projected that about 15% of South African youth, especially young women are prone to engage in drug use and the prospects of coming into contact with nyaope, a highly addictive drug, are higher. Nyaope is mainly smoked, but the prevalence of injecting it is increasing in most regions.Aim: This study aimed to explore and describe the perception of women, who use nyaope, about the factors contributing to nyaope smoking and transitioning to injecting nyaope amongst women in the City of Tshwane Municipality (CoT), Gauteng.Setting: The research was conducted within Community Oriented Substance Use Programme sites across the CoT Municipality.Methods: Qualitative research methods were utilised to explore and describe the perceptions of the participants on factors contributing to the use of nyaope amongst women residing in the CoT. Data were collected through face-to-face interviews and thematically analysed.Results: Intimate partner influence (IPI), peer pressure, being misled by friends, weight loss, lack of effective coping mechanisms and counteracting other drugs contributed to women smoking nyaope. Additionally, a need for an intense high, IPI, influence by the social network, curiosity and cost-effectiveness contributed to women transitioning from smoking to injecting nyaope.Conclusion: The study has established factors contributing to smoking and transition to injecting nyaope as viewed by women residing in the CoT.Contribution: This research affirms that women are influenced by different factors to use and transition to injecting Nyaope.
Evaluation of Concentration of Some Groundwater Parameters around a Major Refuse Dumpsite in Cross River State, Southeastern Nigeria
Authors: Abong A. A. , Atsu J. U. 
Published: June 2022

This study evaluated concentration, possible sources and relationship of groundwater parameters in a major dumpsite in Anantigha Headquarters of Calabar South Local Government Area of Cross River State, Nigeria by collecting samples of borehole water within and around the dumpsite using sterilised containers. Standard methods were used for the analysis. Results obtained show that the mean and standard deviation of the parameters were temperature (26.00±0.10) 0C; pH (3.80±0.36); EC (187.33±41.00) µS/cm; TDS (95.67±20.03) mg/l; NH4 (0.13±0.03) mg/l; Total hardness (19.83±2.56) mg/l; TCC (50.47±31.88) cfu/100ml; FCC (41.00±25.94) cfu/100ml; Fe (0.15±0.03); Zn (0.05±0.03) mg/l and Pb (0.02±0.01) mg/l. The concentration of the various parameters was compared to the World Health Organization (WHO) and National Sanitation Development Water Quality (NSDWQ) standard. Pearson correlation analysis and principal component analysis were used to examine the relationship and possible sources among the parameters. The findings of the study revealed that electrical conductivity EC, TDS, NH4, total hardness, Fe, Zn and Pb in borehole BH2 were within the acceptable limit while Pb concentration of borehole BH1 and BH3, temperature, pH, TCC and FCC were above the permissible limit of WHO/NSDWQ. It is recommended that boreholes should be drilled far away from dumpsites to avoid contamination which poses health risks to man.
Green Synthesis and Characterization of Antibacterial Studies by Iron Oxide Nanoparticles using Carica papaya Leaf Extract
Authors: Usha V. , Amutha E. , Pushpalaksmi E. , Jenson Samraj J. , Rajaduraipandian S. , Gandhimathi S. , Annadurai G. 
Published: June 2022

In present years, the synthesis of iron oxide nanoparticles (IONPs) has established excessive potential in biological applications due to their non-toxic role in biological systems, biocompatibility, and biodegradability. Ongoing research efforts focused on IONPs in the expansion of novel technologies as they can be synthesized with surface modification. Here we have studied the antibacterial effects of IONPs which were synthesized effectively through a green synthesis route by using leaf extract of the Carica papaya plant. The formation of IONPs was confirmed by the color change. The crystallinity of IONPs was determined by XRD and the morphology by using SEM, which showed spherical particles of well-dispersed size. The absorption peak was determined by UV–vis spectroscopy at 390 nm. Average particle size distribution was obtained at 56 nm using PSA. FL spectroscopy indicated the higher emission wavelength by redshift at 641.6 nm. TGA showed that the IONPs are thermally stable up to 200⁰C with no decomposition. The outcome would pave a way for utilizing IONPs for better biomedical application.
A Sociolinguistic Analysis of Cloth Names among the Ga and Dangme People of Ghana
Authors: Ollennu Yvonne Akwele Amankwaa , Owulah Francis Tsatsu , Obeng Patience 
Published: June 2022

Varied ways are used for communication which may either be verbal or non-verbal. Non-verbal occurs in different forms and one is kinesics which includes gestures, facial expression, touching, eye contact and mode of dressing. The paper focuses on the aspect of dressing by examining traditional cloth worn among the Ga and Dangme people. It investigates the cloth types and their name source. It further examines the choice of cloth worn among Dangme and Ga in relation to function or ceremony. Additionally, it did a brief morphosyntactic analysis of the cloth names. The paper employed the visual semiotic theoretical framework by de Saussure. The data were gathered from sellers of cloth in the Accra Business Centre and some markets in the Dangme speaking areas through photography, semi-structured interviews, observation and notetaking. The data was then subjected to a sociolinguistic analysis. It was revealed in the paper that the sources of the name were from events, occasions, requested names and names derived from the motifs. The paper revealed morphosyntactically that the names of cloth are derived from phrases, sentences, personal names, wise sayings, proverbs and others. The names are mostly misspelled because they are not written by experts of the language. Furthermore, the colour of the cloth also determines the event to which one can wear it. Insinuations, the act of thanksgiving and congratulatory messages are some of the information relayed to the public upon usage. Lastly, the paper shows that in contemporary times, most relatively young people do not have much ideas about names of cloths and how they impact their usage.
KESENIAN KEBO BULE SEBAGAI STRATEGI PENGEMBANGAN WISATA PADA OBJEK WISATA RELIGI DESA SUKOSARI KECAMATAN BABADAN KABUPATEN PONOROGO
Authors: Rudianto Rudianto , Widaningrum Ida , Widiyahseno Bambang 
Published: June 2022

Penelitian ini dilatar belakangi adanya kontraproduktif masyarakat pemerintah desa dalam mengembangkan objek wisata desa. Sedangkan potensi desa memiliki cagar budaya berupa makam dan masjid Kiai Imam Puro salah seorang tokoh penyebar agama Islam pertama kali di Ponorogo bagian barat tahun 1748 M dan banyak dikunjungi peziarah tidak kurang 1000 orang setiap tahunnya. Potensi lain seperti paguyuban kesenian kebo bule, reog, pengrajin UMKM, pasar, dan lahan kosong di sekitar cagar budaya belum diberdayakan dengan baik. Oleh karena itu penelitian ini bertujuan untuk menunjukkan kepada publik tentang strategi pengembangan wisata pada objek wisata religi desa Sukosari Kecamatan Babadan Kabupaten Ponorogo. Jenis dari penelitian ini adalah penelitian kualitatif dengan pendekatan fenomenologis. Untuk mengumpulkan data menggunakan teknik observasi, wawancara, dokumentasi, dan Focus Group Discussion (FGD). Data primer diperoleh melalui informan kunci yaitu pengurus masjid dan makam Imam Puro, kepala desa Sukosari, tokoh masyarakat, ketua paguyuban seni dan budaya, peziarah makam, dan warga setempat. Adapun untuk data sekunder diperoleh melalui dokumen, manuskrip, buku sejarah, artikel, website dan sumber lain yang relevan dengan teman penelitian. Untuk menganalisis data peneliti menggunakan teknik analisis SOAR (Strangths, Opportunities, Aspirations, dan Results). Hasil penelitian menunjukkan bahwa strategi pengembangan wisata desa yang dapat dikembangkan antara lain: pertama, Pengembangan pengelolaan cagar budaya berupa makam dan masjid Kyai Imam Puro; kedua, pemberdayaan kesenian kebo bule, reog, UMKM, dan potensi pasar untuk destinasi wisata desa; dan ketiga, pemanfaatan lahan kosong di sekitar makan dan masjid untuk rest area dan pertunjukan seni dan menjajakan produk-produk lokal.
DAMPAK MENULIS EKSPRESIF TERHADAP TINGKAT STRES, KECEMASAN, DEPRESI PADA MAHASISWA KEPERAWATAN
Authors: Kristina Kristina 
Published: June 2022

Ilmu keperawatan terus mengalami pembaharuan sehingga mahasiswa harus menyesuaikan diri terhadap perubahan dinamis yang terjadi. Banyaknya materi pelajaran yang harus dikuasai dalam waktu singkat disiasati dengan mengerjakan tugas secara berkelompok, tugas makalah, hafalan dan praktikum yang seluruhnya harus diselesaikan tepat waktu sesuai durasi masa kuliah untuk jenjang diploma III. Ekspektasi untuk menjadi sukses secara akademik dan tuntutan lulus uji kompetensi dapat menyebabkan stres, kecemasan dan depresi pada mahasiswa. Metode menulis ekspresif dapat mengurangi tingkat depresi, kecemasan dan stres pada mahasiswa keperawatan sehingga proses belajar selama masa kuliah menjadi efektif dan menyenangkan. Desain penelitian ini adalah pra-eksperimen dengan menggunakan satu kelompok subyek penelitian, melibatkan satu kelompok responden. Sebelum diberi perlakuan, dilakukan pengukuran tingkat depresi, kecemasan dan stres pada responden menggunakan alat ukur Depression Anxiety Stres Scale (DASS) questionarre 42 item, setelah itu responden melakukan menulis ekspresif selama empat hari, lalu satu bulan kemudian dilakukan pengukuran tingkat depresi, kecemasan dan stres menggunakan DASS 42 kuesioner untuk melihat perubahan tingkat stres akademik pada responden. Uji statistik menggunakan program SPSS paired-t test. Menulis ekspresif secara signifikan dapat menurunkan tingkat stres, kecemasan dan depresi yang dialami responden dengan nilai signifikan .000. Penggunaan metode menulis ekspresif dapat meningkatkan emosi positif dalam diri responden.
KEPUASAN PESERTA DIDIK DENGAN ICT INFRASTRUCTURE SEBAGAI VARIABEL PEMODERASI DALAM PENGGUNAAN LEARNING MANAGEMENT SYSTEM
Authors: Rokhimah Siti , Sirait Afni 
Published: June 2022

Learning Management System (LMS) merupakan salah satu platform digital yang memfasilitasi kegiatan pembelajaran khususnya selama Pandemi Covid 19 sebagai media komunikasi dua arah antara pendidik dan peserta didik. Penggunaan platform pembelajaran tersebut mendapatkan berbagai respon dari pengguna baik oleh pendidik maupun peserta didik. Tujuan Penelitian ini adalah untuk menganalisis respon pengguna terutama peserta didik dalam hal kepuasan dalam kaitannya dengan penggunaan LMS dengan dukungan dari ICT Infrastructure. Kepuasan dilihat dari Usefulness, Compatibility, dan Reliability. Responden penelitian ini sebanyak 262 responden yang berasal dari berbagai daerah dengan pengumpulan data menggunakan kuesioner pada google form yang kemudian diuji validitas, reliabilitas dan model fit menggunakan alat analisis War PLS 7.0. Hasil pengujian menunjukkan bahwa Usefulness berpengaruh signifikan terhadap kepuasan pengguna dimediasi dengan ICT Infrastructure (dengan nilai koefisien jalur sebesar 0,256, p value <0,001). Compatibility berpengaruh signifikan terhadap kepuasan pengguna dimediasi dengan ICT Infrastructure (dengan nilai koefisien jalur sebesar 0,427, p value <0,001). Reliability berpengaruh signifikan terhadap kepuasan pengguna dimediasi dengan ICT Infrastructure (dengan nilai koefisien jalur sebesar 0,249, p value <0,001). Model fit dengan pengujian nilai VIF 1,623 dan Nilai GoF sebesar 0,495. Hasil penelitian menunjukkan bahwa mahasiswa puas dengan adanya LMS dalam hal Usefulness (kegunaan), Compatibility (kesesuaian), dan Reliabiity (kestabilan) dengan didukung oleh ICT Infrastruktur yang memadai seperti jaringan maupun konfigurasi laptop, sehingga merupakan platform pembelajaran yang andal untuk peserta didik.
ANALISA PARAMETER 3D PRINTING TIPE FDM TERHADAP AKURASI DIMENSI DENGAN FILAMEN BERBAHAN DAUR ULANG PLASTIK LOW DENSITY POLYETHYLENE (LDPE) DAN POLYPROPYLENE (PP)
Authors: Saputra Tri Hannanto , Hutama Adhi Setya , Ningsih Ana , Pamasaria Herda Agus 
Published: June 2022

Perkembangan mesin 3D printing dapat membawa dampak negatif bagi lingkungan karena dapat meningkatkan jumlah sampah plastik. Pembuatan 3D printing filament dari bahan plastik daur ulang merupakan salah satu langkah tepat untuk mengatasi permasalahan sampah plastik, selain itu juga sejalan dengan semakin maraknya penggunaan mesin 3D printing khususnya dengan metode FDM. Optimalisasi 3D printing filament dari bahan plastik daur ulang merupakan salah satu langkah tepat untuk mengatasi permasalahan sampah plastik. Namun, diperlukan parameter yang tepat untuk mengolah filamen dari bahan plastik daur ulang menjadi produk cetakan dengan mempertimbangkan kualitas hasil. Penelitian ini bertujuan untuk mendapatkan parameter proses yang optimum pada mesin 3D printing FDM untuk menghasilkan kualitas produk yang maksimal dari bahan plastik daur ulang, sehingga sampah plastik dapat dikurangi. Penelitian ini menggunakan mesin 3D Printing tipe FDM dan filamen plastik daur ulang Low Density Polyethylene (LDPE) dan Polypropylene (PP) sebagai bahan cetak. Metode penelitian yang digunakan yaitu menggunakan metode taguchi. Parameter penelitian yang digunakan adalah printing temperature, layer height dan print speed. Kualitas diukur dengan dimensi yang terdiri dari panjang (sumbu x) dan lebar (sumbu y), geometri yang terdiri dari tegak lurus dan paralelisme, dan kekasaran permukaan produk. Pengolahan data menggunakan metode Taguchi yang dipadukan dengan PCR-TOPSIS. Hasil penelitian menunjukkan bahwa Parameter optimum untuk filament berbahan recycle LDPE adalah kombinasi printing temperature 230 0C, layer height 0.16 mm dan print speed 30 mm/s. Parameter optimum untuk filament berbahan recycle PP adalah kombinasi printing temperature 245 0C, layer height 0.12 mm dan print speed 35 mm/s.
IDENTIFIKASI NILAI-NILAI KEARIFAN LOKAL TUTURAN PATA DELA MASYARAKAT NGADA DALAM UPAYA PENDIDIKAN KARAKTER
Authors: Margaretha Dhiu 
Published: June 2022

Pendidikan karakter di Indonesia telah banyak dilakukan dengan berbagai pendekatan, tetapi masih jarang berlandaskan pada budaya dan kearifan lokal. Indonesia adalah negara yang kaya dengan budaya dan nilai-nilai lokal, sejalan dengan banyaknya suku, bahasa, adat istiadat, dan kebiasaan hidup. Pata Dela adalah kearifan lokal etnis Ngada, yang mengandung nilai-nilai luhur yang perlu diidentifikasi dan dianalisis implikasinya dalam pendidikan karakter. Desain penelitian yang digunakan adalah pendekatan kualitatif jenis studi kasus. Penentuan subyek penelitian menggunakan teknik purposive sampling, dan informan adalah tokoh adat di Kelurahan Mangulewa, Kecamatan Golewa Barat Kabupaten Ngada NTT. Pengumpulan data menggunakan wawancara dan studi literatur. Penelitian ini bertujuan untuk mengidentifikasi dan mendeskripsikan nilai-nilai pendidikan karakter yang terkandung dalam tuturan pata dela. Data dianalisis secara kualitatif dengan tahapan reduksi, display, dan penarikan kesimpulan. Hasil penelitian ini adalah tuturan Pata Dela mengandung nilai-nilai yang berisikan kewajiban dan larangan yang bermaksud mendidik individu untuk berperilaku baik (modhe), benar (molo), indah-bersih (bila), dan kudus-suci (milo), yang mempresentasikan nilai-nilai pendidikan karakter yaitu disiplin, toleransi, kerja keras, kreatif, mandiri, persatuan, kerja sama, kerendahan hati, menghormati hak orang lain, tanggung jawab, hemat, peduli sesama, dan peduli lingkungan.
MEMBANGUN CHATBOT LAYANAN HELPDESK PERPAJAKAN KPP PRATAMA JAKARTA SETIABUDI SATU
Authors: Aji Agung Siswanto Bayu 
Published: June 2022

Pelayanan helpdesk kepada wajib pajak di KPP Pratama Jakarta Setiabudi Satu dilakukan secara langsung tatap muka dan melalui live chat menggunakan aplikasi perpesanan WhatsApp. Untuk meningkatkan layanan helpdesk secara live chat, perlu alat bantu yang dapat menjawab pertanyaan yang sering ditanyakan wajib pajak secara cepat, tepat dan tanpa dibatasi jam kerja. Penelitian ini bertujuan merancang alat bantu berupa chatbot yang berjalan di aplikasi perpesanan WhatsApp. Chatbot dibangun dengan metode Rapid Application Development (RAD) melalui platform pengembangan tanpa koding. Aplikasi pembangun chatbot yang digunakan adalah Autoresponder for WhatsApp dan WhatAuto – Reply App yang tersedia di Google Playstore. Hasil pengujian fungsional (black box testing) menunjukkan chatbot yang dirancang dapat bekerja dengan baik dan merespon sesuai kata kunci yang ada dalam pangkalan data (data base).
Identifying promising anticancer Sulforaphane derivatives using QSAR, Docking, and ADME studies
Authors: Heda Prachi , Ravishankar Sahana , Shankar Aditi , Chaganti Shrimayi , Rajan Dishita , Parekh Riya , Renganathan Gayathri 
Published: June 2022

In cruciferous vegetables such as broccoli, sulfur-rich isothiocyanates, most notably sulforaphane (SFN), has shown anti-cancer properties, including cell cycle regulation, inducing apoptosis, and metastasis. Sulforaphane is a natural antioxidant that regulates several signal transduction pathways controlling oxidative stress, cellular defense, and cardiovascular disease. This paper attempts to elucidate the most drug-like SFN derivative through computational methods, including molecular docking, Quantitative Structure-Activity Relationship (QSAR), and absorption, distribution, metabolism, and excretion (ADME) analysis. From our studies, we can conclude that phenylethyl isothiocyanate (PEITC) has the most therapeutic potential out of a small set of 7 SFN derivatives. It is a confirmed lead-like compound by testing QSAR descriptors, notably the Dragon consensus drug-like score and lead-like score 2. PEITC also proves to be the most bioavailable derivative, as it is predicted to have high gastrointestinal absorption (GIA) and blood-brain barrier (BBB) permeability. In addition, it is in the optimal range for 5 out of 6 bioavailability properties proposed by the Abbot Bioavailability Score1. Lastly, from docking studies, PEITC had the highest average binding affinity overall, meaning that it holds a vital role in cancer prevention through molecular mechanisms.