bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of inhaler using technique among adult asthma patients in Bangladesh: a facility-based cross-sectional study
Authors: Rafi Md. Abdur , Hasan Mohammad Jahid , Mily Sabrina Jahan , Tashrik Symom , Bonna Atia Sharmin , Jannat Ferdousy , Tahmin Chowdhury Ibtida , Shrestha Abhigan babu , Seemanta Senjuti , Rashid Afsana , Mahjabeen Mosarrat , Nura Nurunnahar , Shahriar Tasnim , Mahadi Ashrafur Rahaman , Ahmed Kawser , Haque Md. Azizul , Hossain Md. Golam 
Published: September 2022

Abstract
Background: Inhaler using technique has influences on disease control in patients with bronchial asthma. The objective of this study was to assess the inhaler using technique and factors associated with correct technique among adult asthma patients in northern Bangladesh.Methods: A total 357 asthma patients were recruited from medicine outpatient department of Rajshahi Medical College Hospital (RMCH) from November 2020 to January 2021. All patients were stable and using either metered dose inhaler (MDI) with or without spacer or dry powder inhaler (DPI). Demographic and disease details were collected by direct interviewing of the patients and inhaler using technique were also observed. A preformed checklist was used for marking the activities of the patients. Inhaler using technique was defined as incorrect if there was one or more critical error observed during using the prescribed inhaler. Logistic regression model was used to determine the predictors of incorrect inhaler using technique. Results: Almost 77% of the MDI users, 85% of the MDI with spacer users, and 76% of the DPI users had at least one or more critical error in handling their inhaler devices. Most commonly missed critical steps were breathing in adequately during inhalation (40% in MDI and 39% in DPI users) and holding breath after inhalation (54% in MDI and 77% in DPI users). Patients with lower educational attainment (aOR 4.56, 95% CI 1.13-18.37, p<0.05), middle-income family (aOR 6.44, 95% CI 1.73-24.03, p<0.01), self-reported difficulty of inhaler technique (aOR 3.18, 95% CI 1.58-6.41, p<0.01), seeking care from non-qualified practitioners (aOR 2.86, 95% CI 1.42-5.75, p<0.01) and no demonstration of inhaler technique (aOR 2.07, 95% CI 1.71-3.01, p<0.05) or demonstration from non-qualified practitioners (aOR 2.41, 95% CI 1.79-4.36, p<0.05) had higher chance of incorrect inhaler using technique.Conclusion: Majority of the asthma patients included in our study had one or more critical error in their inhaler using technique especially in patients with lack of inhaler using training. Patient counseling and demonstration of inhaler using technique during prescription might increase the proportion of patients practicing right technique of inhaler.
Optimization of hydrodistillation extraction using response surface methodology and Chemical composition of essential oil from Moroccan endemic medicinal plant Ballota hirsuta
Authors: Ou-Ani Omar , Oucheikh Lahcen , Dabbous Axel , Znini Mohamed , Costa Jean , Majidi Lhou 
Published: September 2022

Abstract
The present study describes for the first time the optimization of the extraction by hudrodistillation and chemical composition of the essential oil (EO) of Ballota hirsuta aerial parts using Gas chromatography (GC/FID) and GC-mass spectrometry (GC/MS) analysis. Single-factor experiments and response surface methodology (RSM) based on a central composite design (CCD) were used to optimize the EO extraction parameters including drying period (0–21 days), extraction time (60–240 min) and water/plant ratio (5–20 ml/g). The optimum conditions for obtaining the best yield (0.91%) are a drying period of 7 days, an extraction time of 120 min and a water/plant ratio of 10 ml/g. Under these optimum condition, GC/FID and GC/MS enabled the identification of forty-three volatile components representing 82.3% of the total of EO. Germacrene-D (16%), Z-Phytol (7.7%), α- Cadinol (7.3%) and Carvacrol (6.7%) were the main constituents of this EO.
Spatial distribution of Thrips tabaci Lindeman on rabi onion in north western Indian Himalayan regions
Authors: Kaundal Priyanka , SOOD A. K. 
Published: September 2022

Abstract
Spatial distribution of Thrips tabaci Lindeman on rabi onion was assessed in mid-hill regions of Himachal Pradesh, representing north-western Indian Himalayas. Thrips followed negative binomial distribution in onion. Based on the Lewis index, Index of dispersion, Morisita coefficient of dispersion, Lloyd’s mean crowding and Index of patchiness it was observed that in early stages of crop growth stages of rabi onion, thrips were distributed randomly whereas in later crop stages, thrips distribution was aggregated/ overdispersed/ clumped. Aggregated distribution of thrips was also confirmed by Taylor’s power law and Iwao’s patchiness regression index with the corresponding values of 1.29 and 2.65. For estimation of thrips population in vegetative, bulb initiation and bulb development stage, the mean number of samples needed were 15476, 760 and 270, respectively at P = 0.1 (precision level of 90%). Whereas at 80% (P = 0.2), relatively small number of samples were needed (869, 190 and 68) for corresponding crop stages.
WITHDRAWN: H 2 O AutoML-LIME: an integrated modelling approach for predicting cervical cancer in Women
Authors: Prusty Sashikanta , Patnaik Srikanta , Dash Sujit Kumar 
Published: September 2022

Abstract
Background
Cancer positioning a major disease, particularly for middle-aged people, which remains a global concern that can be developed in the form of abnormal growth of body cells at any place in the human body. Cervical cancer, often known as cervix cancer, is cancer present at the female cervix. In the area where the endocervix (upper two-thirds of the cervix) and ectocervix (lower third of the cervix) meet, the majority of cervical cancers begin.
Objective
Despite an influx of people entering the healthcare industry, the demand for Machine Learning (ML) specialists has recently outpaced the supply. To close the gap, user-friendly application, such as H2O, has made significant progress these days. However, the traditional ML technique handles each stage of the process separately; whereas H2O AutoML can automate a major portion of the ML workflow, such as automatic training and tuning of multiple models within a user-defined timeframe.
Methods
Thus, this work aims at implementing the H2O AutoML-LIME technique, to predict cervical cancer at its early stages. Moreover, this model has capable of training the best model in less amount of time which helps in reducing the human effort over traditional ML techniques. The Stacked Ensembles approach, on the other hand, will be automatically trained H2O models to create a highly predictive ensemble model that will outperform the AutoML Leaderboard in most instances. Additionally, LIME (Local Interpretable Model-Agnostic Explanations) has been implemented over the H2O AutoML model, to uncover black boxes and to explain every individual prediction in our model.
Results
After predicting our proposed model with three different probabilities, gives 0.13, 0.05, and 0.13 percent of chances cervical cancer respectively.
Burden of Gender Based Violence in Ethiopia in case of High School Female Students: Systematic review and Meta-analysis
Authors: Mingude Alemu Basazin , Habtegiorgis Samuel Derbie , Dejene Tadesse Mamo 
Published: September 2022

Abstract

Background Gender-based violence (GBV) violates human rights, has terrible repercussions on the educational system, and is remarkably underreported. The primary objective of this systematic review and meta-analysis was to determine the combined prevalence of gender-based violence (GBV) and its determinants among female students in high schools in Ethiopia. Methods Data base search were conducted through PubMed, Science Direct, HINARI. Web of Science,and Cochrane Library. Essential data were extracted using a Microsoft Excel format and analyzed by using STATA Version 17.0. Heterogeneity were checked by using heterogeneity I2test and p-values at (I2 = 98.9%, p < 0.001). To depict publication bias, the funnel plot was utilized, and Egger's and Begg's tests were used to examine it statistically. Subgroup analysis was performed to assess the variation of primary research Result The pooled prevalence of lifetime GBV was 50% (95% CI: 41, 59). The pooled prevalence of life time sexual violence, physical violence and psychological violence were found to be 33% (95% CI: 24, 42), 39% (95% CI: 33, 45), and 30% (95%CI: 14, 46) respectively. Alcohol use (AOR: 3.32; 95% CI, 1.70, 6.46), having boyfriend (AOR: 2.61; 95% CI, 1.01, 6.77), being rural residence (AOR: 1:89; 95% CI, 1.52, 2.35) and smoking cigarette (AOR: 7.88; 95% CI: 5:76, 10.77) were found to be determinants of gender based violence. Conclusion High school students in Ethiopia struggle greatly with gender-based violence. This issue needs to be addressed by both governmental and non-governmental entities.
Structure and Complexation Equilibria of Silver (I) with 2-(4-nitro-benzaldehyde)-benzimidazole-hydrazone
Authors: El-Dossoki F. I. , Belal Arafa A. M. , El-Seify Fathy A. 
Published: September 2022

Abstract
imple and sensitive spectrophotometric determination method of trace amounts of silver(I) ion using 2-(4-nitro-benzaldehyde)-benzimidazole-hydrazone has been devised. Silver(I) react rapidly with this reagent and forms a red stable chelate, in weak acid medium, which obeys Beer’s law at 496 nm with a molar absorptivity 6.9 ⋅ 103 l mol cm-1 and Sandll’s sensitivity 1.56 ⋅ 10− 3 µg cm-3. The stoichiometry and stability constant of silver chelate has determined using spectrophotometric, potentionmetric and conductometric methods. Interferences from various foreign ions were studied. The nature of the solid chelate has also studied.
The epidemiological trends of Biliary tract cancers in United States
Authors: Jiang Yong , Jiang Liyong , Li Feiyu , Li Qingbin , Yuan Shuai , Huang Songhan , Yan Xiangyu , Chen Ji , Fu Yingda , Li Hongxin , Li Shenhao , Liu Jun 
Published: September 2022

Abstract
Background: Biliary tract cancers (BTCs) are a series of heterogeneous malignancies that are broadly grouped based on the anatomical site where they arise into subtypes including intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC), gallbladder cancer (GBC), and ampulla of Vater cancer (AVC).Methods and Results: The present study serves to provide an overview of the epidemiology of various biliary tract cancers (BTCs) based on data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database from 2000-2018. Differences in both incidence and mortality rates were observed for these distinct BTCs as a function of age, sex, ethnicity, and calendar year. In 2018, BTCs emerged as the 5th most prevalent form of alimentary tract cancer in US. While increasing trends were observed with respect to ICC incidence and associated mortality, the rates of GBC, ECC, and AVC have remained stable, as have the corresponding mortality rates. The most common and deadliest BTCs in 2018 were ICC and GBC among males and females, respectively. The ethnic groups exhibiting the highest incidence rates of these different BTCs were Black individuals for GBC, Asian and Pacific Islanders for ECC and AVC, and White or Asian and Pacific Islanders for ICC. The incidence of all of these forms of BTC rose with age. There were a few changes among BTCs in staging, locoregional surgical treatments, adjuvant therapies, and prognostic outcomes from 2000-2018.Conclusions: The epidemiological characteristics, staging, locoregional surgical treatments, adjuvant therapies, and prognostic outcomes were distinct for each of these BTCs.
Primary intestinal-type adenocarcinoma of the vulva with high tumor mutational burden and cancer-associated mutations: a case report
Authors: Sato Hanako , Murakami Kosuke , Otani Tomoyuki , Matsumura Noriomi 
Published: September 2022

Abstract
Background Vulvar cancer is a rare disease, accounting for about 5% of gynecological malignancies. Intestinal-type adenocarcinoma of the vulva is extremely rare, and details regarding its origin and related genetic mutations are unknown. Treatment options for this cancer have not been defined. Case presentation A 63-year-old Japanese woman came to the hospital because she was aware of a vulvar mass. There was a 1 cm mass on the dorsal side of the vulva, just outside the remains of the hymen. Biopsy revealed suspected adenocarcinoma, and wide local excision was performed. Based on histopathology and immunohistochemistry, the mass was diagnosed as intestinal-type adenocarcinoma. No other primary lesions were found, and the vulva was considered the primary site. The Gene panel test (FoundationOneCDx assay) showed a high tumor mutational burden and gene mutations in TP53, KEL, RB1, RNF43, PTEN, GNAS, and PIK3CA. ConclusionsIn cases of intestinal-type adenocarcinoma of the vulva, it may be helpful to check tumor mutational burden and gene mutations for treatment selection.
Effect of Permeability on Micropolar Fluid with Nanoparticles Flowing Through a Core Region in a Stenosed Artery
Authors: Prasad K. Maruthi , Sreek Bheema , Yasa Prabhaker Reddy 
Published: September 2022

Abstract
The flow of mixed two-layered, micropolar fluid comprising nanoparticles across a permeable stenosed artery is examined through a theoretical modeling. In a stenosed artery, the fluid flow going through two regions (specifically, the Peripheral and Core) is considered to be most illustrated by a two-layered model. The fluid in the peripheral layer is a Newtonian fluid, whereas the micropolar fluid containing nanoparti-cles in the core region performs as a non-Newtonian fluid. The closed expressions of flow characteristics, like axial velocity profile, flow resistance , shear stress, temperature profile and concentration distribution. Effect of Permeability on Micropolar Fluid with Nanoparticles are found to determine the governing equations using Homotopy Perturbation Method (HPM) with the assumption of mild stenosis. The significance of flow properties on flow conformation, wall shear stress and velocity profiles are discussed graphically. A remarkable conclusion is that, the axial velocity profile with the increase of local nanopar-ticle Grashof number (Br) is found increasing in the region −0.5 to 0.5 and decreasing in the other region. To investigate the properties and fluid flow pattern of momentum transfer, streamlines are drawn.MSC Classification: 92C10 , 76Z05
Non-invasive ventilation prevents post-operative respiratory failure in patient undergoing bariatric surgery: a retrospective analysis
Authors: Imperatore Francesco , Gritti Fabrizio , Esposito Rossella , Giudice Claudia del , Cafora Chiara , Liguori Giovanni , Bossone Vito , Catauro Antonio , Pace Maria Caterina , Docimo Ludovico , Gambardella Claudio 
Published: September 2022

Abstract
Purpose Postoperative non-invasive ventilation (NIV) has been proposed as an attractive strategy to reduce morbidity in obese subjects undergoing general anesthesia. The increased body mass index (BMI) correlates with loss of perioperative functional residual capacity, expiratory reserve volume, and total lung capacity. The aim of the current study is to evaluate the efficacy of NIV in post-anaesthesia care unit (PACU) in reducing post-extubation acute respiratory failure (ARF) after biliointestinal by-pass (BIBP) in obese patients.Methods A retrospective analysis was conducted from January 2019 to December 2020 to compare acute respiratory failure within the first 72 postoperative hours and oximetry values of obese patients undergone BIBP after postoperative NIV adoption or conventional Venturi mask. Results 50 patients received NIV postoperative protocol and 57 patients received conventional Venturi Mask ventilation were included in the study. After 120 min in PACU pH, pCO2, pO2 and SpO2 resulted better in NIV Group vs Control Group (p<0.001). In the postoperative 72 hours, 1 patient (2%) in NIV group vs 7 patients (12.2%) in Control group developed acute respiratory failure. Therefore, conventional Venturi Mask ventilation resulted significantly associated (p<0.05), to postoperative ARF with an RR of 0.51 (IC 0.27-0.96). Conclusion After bariatric surgery, the short term NIV during PACU observation promotes a more rapid recovery of postoperative lung function and oxygenation in obese patients, reducing the critical care necessity in the days following surgery. Therefore, as day case surgery becomes more advocated even for the morbid obesity, it might be considered a necessary procedure.
A multigene circulating biomarker to predict the lack of FOLFIRINOX response after a single cycle in patients with pancreatic ductal adenocarcinoma (PDAC)
Authors: Eijck Casper W.F. van , de Koning Willem , Sijde Fleur van der , Moskie Miranda , Koerkamp Bas Groot , Homs Marjolein Y.V. , Burg Sjoerd. H. van der , Eijck Casper H.J. van , Mustafa Dana A.M. 
Published: September 2022

Abstract
Introduction:
FOLFIRINOX chemotherapy showed promising results in treating patients with pancreatic ductal adenocarcinoma (PDAC). However, many patients and physicians are reluctant to start FOLFIRINOX due to its high toxicity and limited clinical response rates. In this study, we investigated the effect of a single cycle of FOLFIRINOX, in combination with a granulocyte colony-stimulating factor (G-CSF), on the blood immune transcriptome of PDAC patients. We aimed to identify an early circulating biomarker to predict the lack of FOLFIRINOX response.
Methods
Blood samples of 68 patients from all PDAC disease stages, who received at least four FOLFIRINOX cycles, were collected at baseline and after the first cycle. Patients were divided into “disease control” and “progressive disease” following the RECIST criteria 1.1. RNA was isolated and targeted immune-gene expression profiling was performed using the PanCancer Immune profiling panel of NanoString. The FOLFIRINOX delta Gene Expression Profiling (FFX-ΔGEP) score was calculated using the weight of eight genes following LASSO multivariate regression analysis.
Results
Comparing the immune gene expression profile of samples at baseline to after a single FOLFIRINOX cycle resulted in the identification of 395 differentially expressed genes (BH.P < 0.05), correlating to 30 significant alterations in relative immune cell abundancies and pathway activities (BH.P < 0.05). The patient cohort included 48 disease control and 10 progressive disease patients. The FFX-ΔGEP score, composed of eight genes (BID, FOXP3, KIR3DL1, MAF, PDGFRB, RRAD, SIGLEC1, and TGFB2), could predict the lack of FOLFIRINOX response with a leave-one-out cross-validated AUC [95% CI] of 0.87 [0.60–0.98]. Our FFX-ΔGEP score outperformed the predictiveness of absolute and proportional ΔCA19-9 values with an AUC [95% CI] of 0.70 [0.27–1.0] and 0.52 [0.24–0.80], respectively. Notably, immune-gene expression profiles of baseline samples could not predict the lack of FOLFIRINOX response.
Conclusions
A single FOLFIRINOX cycle, combined with G-CSF, alters the peripheral immune transcriptome indisputably. We revealed a novel multigene FFX-ΔGEP score which is, to our knowledge, the first gene expression-based early circulating biomarker that predicts the lack of FOLFIRINOX response after only a single cycle. Validation in a larger independent cohort of samples is crucial before clinical implementation.
Optimization of Spring Parameters by Using the Bees Algorithm for the Foldable Wing Mechanism
Authors: Sahin Murat , Kulunk Zafer 
Published: September 2022

Abstract
In this study, the design of the torsion and compression springs of the foldable wing mechanism used in the missile is discussed as an optimization problem. The objective functions discussed in this study are to maximize the energies of the springs and to minimize the opening time of the wing. In the optimization studies, the material type of the springs was kept constant and the wire diameter, coiling diameter, coiling number, and deflection were determined as variables. While there are geometric constraints for the variables due to the dimensions of the mechanism, there are also safety factor constraints due to the loads to which the springs are exposed. The Bees Algorithm was used to solve this optimization problem. The energy values obtained with BA were better than the values obtained with the DOE study before. The springs and mechanism designed with the parameters obtained as a result of the optimization were first analysed in the ADAMS program. Afterward, the springs produced were integrated into the real mechanism, and experimental tests were carried out. As a result of the tests, it has been seen that the wing opens in about 90 ms. This value is well below the project target of 200 ms. In addition, there is only a 15 ms difference between the analysis results and the experimental results.
Opposing trends of the Subantarctic Mode Water thickness in the South Indian Ocean driven by atmospheric forcing and interior mixing
Authors: Jiang Jindong , Shi Jiuxin , Rintoul Stephen R. 
Published: September 2022

Abstract
Formation and subduction of Subantarctic Mode Water (SAMW) contributes to the upper cell of the Southern Ocean overturning circulation and transports anthropogenic heat and carbon into the ocean interior. Understanding of the processes driving change in SAMW is therefore needed to assess the ocean’s capacity to store heat and carbon. An analysis of Argo data reveals that the SAMW thickness increased in the eastern subduction area of the South Indian Ocean (SIO) during 2005−2020, and decreased in the central SIO outside the subduction area. The increasing and decreasing trends of SAMW thickness are driven by enhanced subduction and by erosion through mixing with warmer overlying waters, respectively. The changes in SAMW subduction reflect changes in air-sea exchange. Trends in winter sea level pressure associated with an amplification of the winter atmospheric zonal wave 3 pattern caused increased equatorward flow and marine cold air outbreaks in the eastern SIO, driving larger ocean heat loss, deeper mixed layers, and stronger subduction by lateral induction. SAMW subducts beneath lighter waters that warmed during the 2005−2020 period. Mixing with the warmer overlying water eroded the upper part of the SAMW layer, causing deepening of the SAMW low potential vorticity core, and thinning of the SAMW in the central SIO. These results demonstrate that both anomalous meridional atmospheric circulation and erosion by interior mixing influence the thickness, and hence heat and carbon storage capacity, of the SAMW.
Low-temperature plasma irradiation of Ringer`s lactate generates heterogeneous molecules for cancer treatment
Authors: Miron Camelia , Kashiwagura Satoshi , Britun Nikolay , Ito Daiki , Iwata Naoyuki , Liu Yang , Kajiyama Hiroaki , Toyokuni Shinya , Mizuno Masaaki , Hashizume Hiroshi , Kondo Hiroki , Ishikawa Kenji , Tanaka Hiromasa , Hori Masaru 
Published: September 2022

Abstract
Low-temperature plasma (LTP) is a promising tool for cancer treatment because irradiated various solutions show selective antitumoral effects on cancer cells. In this study, Ringer`s lactate solution was irradiated by pulsed electrical discharges ignited in argon, nitrogen, and oxygen gas mixtures. The chemical compounds formed by LTP and their effects on non-tumorigenic breast epithelial cells (MCF-10A) and breast cancer cells (MCF-7) were investigated. Among these compounds, glyceric acid increased the cell viability by more than two-fold compared to the control samples for MCF-10A and MCF-7 cells, whereas the tricarballylic acid had a pronounced cytotoxic effect on the cells when incubated with solutions of 0.6 mM to 50 mM concentrations. The results show that the LTP-generated chemical compounds have both, stimulatory and inhibitory effects on cell viability, possibly by influencing the morphology of the cells and physiological functions, depending on the concentration of the generated compounds in the irradiated liquids.