bluuebunny/crossref_metadata_2025_split huggingface dataset:
Collision tumor of invasive squamous cell carcinoma and adenoid cystic carcinoma in the oropharynx: a case report
Authors: Qian Senmi , Feng Meibao 
Published: March 2022

Abstract
Introduction: Primary collision tumors composed of two histologically distinct components are rare in the head and neck, its pathobiological features remain unclear. Case presentation: A man in his late 50s presented with paranesthesia pharynges and underwent upper endoscopy, followed by histopathological examination of biopsy specimens. He seems to have two tumors in the oropharynx with a size of 1.5*1.3cm, and an ulcer focus in the esophagus measuring about 1*0.8cm. Histopathological examination revealed a coexistence tumor of two components in the oropharynx, one was an adenocarcinoma with cribriform and solid growth pattern, with interstitial vitreous degeneration and central necrosis, the other was with a solid growth pattern, which was observed in both oropharynx and esophagus. The patient had a favorable outcome.Conclusion: Correct diagnosis can be challenging and is essential and beneficial for the prognosis of the patient.
Whole-genome sequence and genome annotation of Xanthomonas citri pv. punicae causing bacterial blight on pomegranate
Authors: Manjunatha N , Pokhare S.S , Sharma J , Patil P.G , Thorpe P , Agarrwal R , Chakranarayan M.G , Marathe R.A 
Published: March 2022

Abstract
The complete genome of Xanthomonas citri pv. punicae (Xcp-118), causal agent of bacterial blight of pomegranate, was sequenced using Illumina NextSeq500 platform. The 5.14 Mb genome has 64% GC content and contains 4371 genes with an average size of 980 bp; 4231 protein coding genes, 6 operons for rRNA and 58 tRNAs. Xcp-118 was found closest to Xanthomonas citri pv. punicae strain NCPPB 3563(CP030163) in phylogeny analysis. The complete genome sequence of Xcp-118 will provide novel insights into the pathogenesis of Xcp on pomegranate and may assist in finding a suitable blight resistant pomegranate variety.
Prevalence of cervical ribs and elongated transverse processes in Omani population: a computed tomography-based study
Authors: Subhi Marwa Al , Ajmi Eiman Al , Lawati Abdullah Al , Aswami Husain Al , Sirasanagandla Srinivasa Rao 
Published: March 2022

Abstract
IntroductionCervical ribs are the supernumerary ribs that usually arise from the seventh cervical vertebra. Ethnic and geographical variations in the prevalence of cervical ribs and elongated transverse processes have been reported. We aimed to study the prevalence of cervical ribs and elongated transverse processes in Omani subjects using computed tomography (CT). MethodsA total of 1165 consecutive patient CT scans of the cervical spine who had visited the tertiary care hospital from January 2016 to December 2020 were included in the study. The CT scans were screened for the presence of cervical ribs and elongated C7 transverse processes. The Chi-square test was used to determine the gender influence. Results Cervical ribs were identified in 0.94% of patients with a female dominance (p<0.05). The majority of the cervical ribs were unilateral (54%). The elongated C7 transverse process was identified in 18.45% of patients, with a male to female ratio of 1.36:1. The presence of an elongated C7 transverse process was strongly associated with gender (p< 0.001). ConclusionThe prevalence of cervical ribs in Omani subjects is close to that of generally accepted prevalence worldwide. However, the elongated C7 transverse process prevalence is comparatively high and close to the prevalence of the Saudi population.
Effects of agricultural pesticides on the susceptibility and fitness of malaria vectors in rural south-eastern Tanzania
Authors: Urio Naomi H , Pinda Polius G , Ngonzi Amos J , Muyaga Letus L , Msugupakulya Betwel J , Finda Marceline , Matanila Godfrey S , Mponzi Winifrida , Ngowo Halfan S , Kahamba Najat F , Nkya Theresia E , Okumu Fredros O. 
Published: March 2022

Abstract
Background
Agricultural pesticides may exert strong selection pressures on malaria vectors during the aquatic life stages and may contribute to resistance in adult mosquitoes. This could reduce the performance of key vector control interventions such as indoor-residual spraying and insecticide-treated nets. The aim of this study was to investigate effects of agrochemicals on susceptibility and fitness of the malaria vectors, Anopheles arabiensis across farming areas in Tanzania.
Methods
An exploratory mixed-methods study was conducted to assess pesticide use in four villages (V1-V4) in south-eastern Tanzania. An. arabiensis larvae were collected from agricultural fields in the same villages and their emergent adults examined for insecticide susceptibility, egg-laying, and wing lengths (as proxy for body size). These tests were repeated using two groups of laboratory-reared An. arabiensis, one of which was pre-exposed for 48hrs to sub-lethal aquatic doses of agricultural pesticides found in the villages.
Results
Farmers lacked awareness on the linkages between public health and agriculture sectors but were interested in being more informed. Agrochemicals usage was reported as extensive in V1, V2 & V3 but minimal in V4. Similarly, mosquitoes from V1-V3 but not V4 were resistant to pyrethroids, and either pirimiphos-methyl, bendiocarb or both. Adding the synergist, piperonyl butoxide, restored potency of the pyrethroids. Pre-exposure of laboratory-reared mosquitoes to pesticides during aquatic stages did not affect insecticide susceptibility in emergent adults of the same filial generation. There was also no effect on fecundity, except after pre-exposure to organophosphates, which were associated with fewer eggs and smaller mosquitoes. Wild mosquitoes were smaller than laboratory-reared ones but fecundity was similar.
Conclusions
Safeguarding the potential of insecticide-based interventions requires improved understanding of how agricultural pesticides influence important life-cycle processes and transmission potential of mosquito vectors. In this study, susceptibility of mosquitoes to public health insecticides was lower in villages reporting frequent use of pesticides compared to villages with little or no pesticide use. Variations in the fitness parameters, fecundity and wing length, marginally reflected the differences in exposure to agrochemicals, and should be investigated further. Pesticide use may exert additional life-cycle constraints on mosquito vectors, but this likely occurs after multi-generational exposures.
Endocuff-Assisted Colonoscopy Does Not increase the Sessile Serrated Lesion Detection Rate – A Randomized Controlled Trial
Authors: Ferreira Alexandre , Costa-Santos MP , Palmela Carolina , Gloria Luisa , Cravo Marilia , Canena Jorge , Dinis-Ribeiro Mário 
Published: March 2022

Abstract
Background
Colorectal cancer (CRC) is a leading cause of cancer-related death. Colonoscopy has been shown to decrease the incidence of CRC by facilitating the detection and resection of adenomas and serrated lesions. Endocuff vision (EV) has been shown to increase the detection of adenomas. The aim of this study was to compare the detection of sessile serrated lesions during colonoscopy with and without EV.
Methods
A total of 257 patients who underwent elective colonoscopy were prospectively enrolled. The patients were randomly allocated to one of two groups according to the use of EV (standard colonoscopy vs. colonoscopy with EV). We compared the rates of detection of serrated lesions (including hyperplastic lesions ≥ 10 mm) and adenomas.
Results
The number of serrated lesions per colonoscopy was not significantly higher in the EV group (0.233 vs 0.156, mean difference 0.076, p = 0.381). None of the secondary endpoints regarding the detection rate of adenomas (65.9% vs 66.4%; OR 0.977, 95% CI 0.583–1.638; p = 0.931) or sessile serrated lesions (12.4% vs 7.8%; OR 1.671; 95% CI 0.728–3.836; p = 0.226) were superior in the EV group. The differences were not significantly altered after adjusting for either the Boston Bowel Preparation Score (BBPS) or withdrawal time.
Conclusion
EV did not increase the rate of detection of serrated lesions or adenomas.
A Review of Recent Advances in Cytopathology for Diagnosis of Hepato-Biliary Lesions
Authors: Chandra Smita 
Published: March 2022

Cytology has emerged as an important diagnostic modality for hepato-biliary lesions because of its minimally invasive, rapid turnaround time and cost-effective nature. This is especially important in diagnosis of neoplastic pathology of liver, gall bladder or bile duct where biopsy is difficult and delayed diagnosis may lead to complications or even mortality. The advent of newer molecular diagnostic modalities like polymerase chain reaction (PCR), fluorescent in situ hybridization (FISH), immunochemistry or more recently circulating tumour cells and next generation sequencing (NGS) have not only led to precise diagnosis but are also helpful in targeted therapy and prognostication of tumour. Cytology which is a minimally invasive technique can be judiciously used for advanced molecular analysis for diagnosis and management of hepato-biliary lesions. Awareness regarding the use of cytological samples for molecular analysis in hepato- biliary lesions is essential so that mutational changes may be easily determined without undergoing any invasive technique in these deep-seated lesions. It is also necessary that guidelines on molecular cytology should be chalked out so that uniform reporting is followed with maintenance of high-quality standards.
On the Issue of Free Movement of Financial Services and Capital in the Eurasian Economic Union
Authors: Zhiryaeva E. V. , Naumov V. N. 
Published: March 2022

The article examines the macroeconomic indicators of the EAEU countries, used in quantitative methods for assessing financial integration, as well as a number of documents that form the common financial market (CFM) of the EAEU.Aim. To identify the content of the concept of the EAEU CFM, having determined the elements of control of the movement of financial services and capital, to assess the possibilities of its formation, taking into account the achieved integration.Task. To confirm the hypothesis that the insufficiently high existing level of financial integration in the EAEU is the reason why the mechanisms of the EAEU CFM cannot be sufficiently developed.Methods. Correlation analysis, analysis and comparison of texts.Results. Capital mobility is high in Russia and Kyrgyzstan. Converging consumption growth rates is a sign of equalizing financial risks. The countries differ in their exchange rate regimes, two of them maintain a double exchange rate, three have requirements for the repatriation of foreign exchange earnings. Capital flow measures are multidirectional. The CFM assumes the approximation of legislation in the field of financial services. Countries only commit to cross-border supply and consumption abroad for four subsectors, commercial presence is governed by national legislation, and the presence of natural persons is subject to migration regulations. The obligations to liberalize the services market taken to the WTO are not uniform, and the list of exemptions from obligations under the EAEU Treaty is more restrictive than obligations to the WTO. Most of the foreign exchange regulation measures are implemented in accordance with national laws. Investors from member states do not receive national treatment upon establishment.Conclusion. The hypothesis is confirmed. The significance of the work for the theories of financial integration lies in the identification of the forms in which the CFM EAEU exists. The recommendations are intended for use in the work of the Eurasian Economic Commission.
Pengembangan Buku Digital Berbasis RANDAI Terintegrasi Potensi Lokal pada Materi Keanekaragaman Hayati
Authors: Ulya Husnatul , Arsih Fitri , Alberida Heffi , Rahmi Yosi Laila 
Published: March 2022

The RANDAI learning model is one of the learning models that can be used in biology learning. This model can be applied by using learning media that supports the implementation of the syntax of the learning model, one of which is in the form of a digital book. This study aims to produce an Integrated RANDAI-Based Digital Book on Local Potential on Biodiversity Materials for Class X SMA/MA. This research is a research and development research using the Plomp development model. The subjects in this study were 3 biology lecturers, 1 biology teacher and 31 students. The data obtained in this study are in the form of validity and practicality data. This study resulted in a very valid and practical RANDAI-Based Digital Book Based on Local Potential on Biodiversity Materials for Class X SMA/MA with a validity value of 92.53% meeting the very valid criteria and the practicality value by the teacher with a value of 91.91% meeting the very criteria. practicality and practicality scores by students with a value of 86.93% meet the practical criteria.
Key words: Digital Books, RANDAI Learning Model

Abstrak. Model pembelajaran RANDAI adalah salah satu model pembelajaran yang dapat digunakan dalam pembelajaran biologi. Model ini dapat diterapkan dengan menggunakan media pembelajaran yang mendukung pelaksanaan sintaks dari model pembelajaran tersebut, salah satunya dalam bentuk buku digital. Penelitian ini bertujuan untuk menghasilkan Buku Digital Berbasis RANDAI Terintegrasi Potensi Lokal pada Materi Keanekaragaman Hayati untuk Kelas X SMA/MA. Penelitian ini merupakan penelitian pengembangan (research and development) dengan menggunakan model pengembangan Plomp. Subjek dalam penelitian ini adalah 3 orang dosen Biologi, 1 orang guru biologi dan 31 orang peserta didik. Data yang didapatkan dalam penelitian ini berupa data validitas dan praktikalitas. Penelitian ini menghasilkan Buku Digital Berbasis RANDAI Terintegrasi Potensi Lokal pada Materi Keanekaragaman Hayati untuk Kelas X SMA/MA yang sangat valid dan praktis dengan nilai validitas 92,53% memenuhi kriteria sangat valid dan nilai praktikalitas oleh guru dengan nilai 91,91% memenuhi kriteria sangat praktis dan nilai praktikalitas oleh peserta didik dengan nilai 86,93% memenuhi kriteria praktis.
Kata kunci: Buku Digital, Model Pembelajaran RANDAI
Uso de antibióticos y resistencia antimicrobiana en la unidad de cuidado intensivo neonatal
Authors: García Henao Juan Pablo , García Ríos Juan Manuel , Naranjo Arango Yonatan Andrés , Grajales Rojas Julián , Vinasco Sánchez Luis Gabriel 
Published: March 2022

La sepsis neonatal constituye una de las principales causas de mortalidad neonatal en los países en desarrollo. Los neonatos, en particular los prematuros, tienen un mayor riesgo de infecciones bacterianas, por lo que el manejo con antibióticos constituye la terapia más frecuente en la Unidad de Cuidado Intensivo Neonatal (UCIN), estimándose en hasta un 70%. La presentación clínica de la sepsis neonatal es inespecífica en muchas ocasiones, lo que hace que la antibioticoterapia empírica se inicie tempranamente para evitar consecuencias deletéreas para los pacientes; su inespecificidad la caracteriza como un reto diagnóstico, por lo que diferentes autores han diseñado estrategias para determinar neonatos candidatos a terapia antimicrobiana.
La microbiología permanece en contacto estrecho con la clínica ya que conocer los gérmenes frecuentemente asociados a la sepsis neonatal ayuda a determinar el espectro antibiótico a usar. De igual forma, el conocimiento de la farmacología antibiótica es clave puesto que el tratamiento antibiótico no es inocuo y puede asociarse a aumento de morbilidad o mortalidad. El tiempo de evolución y los factores de riesgo maternos están asociados a los gérmenes responsables esperados, ya descritos por múltiples estudios descriptivos a nivel mundial.
El uso indiscriminado de antibióticos de amplio espectro para el manejo de infecciones en los recién nacidos ha generado un aumento en la resistencia antibiótica, lo que a su vez lleva a tasas más altas de fallo terapéutico con el uso de las terapias antibióticas empíricas. A razón de lo anterior, los Programas de Vigilancia de Uso de Antibióticos juegan un papel determinante para monitorear el cambio en la resistencia a nivel local para ajustar y homogeneizar la práctica médica que logre regular el uso de antibióticos y mitigar la emergente resistencia bacteriana.
Fiebre de malta: reporte de caso
Authors: Castillo López Daniela Rocío , Vargas Rodríguez Ledmar Jovanny , Rozo Ortiz Edwar Jassir , Barón Barón Javier Orlando 
Published: March 2022

Introducción: La fiebre de malta (brucelosis) es una infección zoonótica producida por cocobacilos gramnegativos, intracelulares facultativos, los cuales se transmiten por el consumo de productos animales no pasteurizados infectados, el contacto de la piel o las membranas mucosas con tejido animal infectado, fluidos animales infectados e inhalación de partículas aerosolizadas infectadas.
Caso: Hombre de 34 años residente en zona rural, quien se dedicaba a la ganadería, ingreso a urgencias por presentar cuadro clínico de 15 días de evolución consistente en picos febriles no cuantificados asociados a escalofríos, astenia, adinamia y mialgias. Mediante la correlación clínico-patológica se llegó al diagnóstico de infección por Brucella Abortus. Conclusión: Esta patología es más frecuente en varones adultos. Dentro del cuadro clínico, Los estudios de serológicos (anticuerpos, aglutinación y ensayo inmunocromatográfico) tienen la mayor sensibilidad y especificidad diagnostica. El tratamiento se da con medicamentos que actúen en entornos intracelulares ácidos (tetraciclinas, aminoglucosidos, fluoroquinolonas), esto con el fin de controlar la enfermedad, prevenir las complicaciones y evitar las recaídas.
Fístula colovesical secundaria a diverticulitis complicada: tratamiento laparoscópico. Reporte de caso
Authors: Gómez Pineda Alfonso León , Domínguez Alvarado Gonzalo , Peña Figueroa Paula Andrea , Orozco Castillo Maria Fernanda , López Gómez Luis Ernesto 
Published: March 2022

Introducción: La fístula colovesical es la unión entre la vejiga y el intestino grueso, se presenta en el 2% de los pacientes con enfermedad diverticular del colon, genera síntomas como neumaturia y fecaluria, asociados a infecciones urinarias recurrentes. Los pacientes se diagnostican mediante estudios imagenológicos y su tratamiento generalmente es quirúrgico.
Objetivo: Reportar el caso de tratamiento laparoscópico de paciente con fístula colovesical secundaria a diverticulitis complicada.
Caso clínico: Se presenta el caso de un paciente masculino de 69 años, con antecedente de enfermedad diverticular, cursando con infección de vías urinarias recurrentes, fecaluria y neumaturia. La cistoscopia no mostró trayecto fistuloso y la tomografía abdominopélvica mostró hallazgos inflamatorios y fístula colovesical asociada a diverticulitis complicada. Durante procedimiento laparoscópico se encuentra absceso pericólico sin evidencia del trayecto fistuloso, se realizó drenaje, sutura del colon e interposición del epiplón, sin resección intestinal. Paciente con adecuada evolución postoperatoria con egreso al sexto día. El objetivo del tratamiento quirúrgico se centra en el control de complicaciones generadas por los divertículos, en este caso, la fístula colovesical.
Conclusiones: El procedimiento laparoscópico es de mínima invasión, no presenta la morbilidad que implica una resección de colon o una colostomía y se asocia con una recuperación funcional más rápida.
Predictive value of lactate dehydrogenase to albumin ratio (LAR) in patients with coronavirus Disease 2019 (COVID-19)
Authors: Liu Mingqing , Zhang Luping , Zhang Yingli , Xu Xiaoming , Ma Tantan , Ni Fengming , Xu Hong , Zhang Nan 
Published: March 2022

Coronavirus Disease-2019 (COVID-19) is an emerging acute infectious
disease around the world. Therefore, it is crucial to identify the risk
factors of in-hospital mortality and disease severity for COVID-19
patients. We firstly proposed a biomarker ratio, lactate dehydrogenase
to albumin ratio (LAR) may be more reliable to assess the predictive
value of LAR for in-hospital mortality and early identification of
critical COVID-19 patients. A retrospective study was conducted
including patients (≥18 years old) with laboratory-confirmed COVID-19
infection who had been discharged or had died from 1 February to 29
February, 2020. The study included 321 patients and the median age of
the 321 patients was 63.0 (IQR 51.0-70.0), ranging from 19 to 95 years
old and 180 (56.1%) patients were male. 142 (44.2%) patients had 1 or
more coexisting comorbidity. The most common symptoms on admission were
fever(289[90%]) and cough(258[80.4%]). In multivariable
logistic regression, only older age (OR, 1.11; 95% CI, 1.05-1.16), WBC
count (OR, 1.26; 95% CI, 1.11-1.44), lymphocyte count (OR, 0.78; 95%
CI, 0.62-0.99) and LAR (OR, 1.29; 95% CI, 1.18-1.40) were found to be
significantly associated with in-hospital death. ROC analysis showed
that LAR had a higher AUC (0.917) and the highest specificity(84.0%)
and sensitivity(84.6%). Furthermore, the results showed that LAR had a
higher AUC (0.931) to differentiate critical from mild patients and had
a sensitivity of 87.7% and a specificity of 82.1%. Besides, LAR had an
AUC (0.861) to differentiate critical from severe patients and had a
sensitivity of 86.0% and a specificity of 73.8% and the role of LAR to
distinguish severe from mild patients was the worst. To the best of our
knowledge, a high LAR appears to predict higher odds of mortality and
differentiate critical patients from mild or severe COVID-19 patients.
Au12@Au30 core-shell Molecule Constituted of an Icosahedron and an Icosidodecahedron
Authors: Bai Chunyuan , Li Hongfei , Zun Xie , Dong Yichen , Liu Shulan 
Published: March 2022

A stable core-shell structure Au@Au
has been investigated by first-principles calculations. The
Au@Au with Ih symmetry is composed
of an icosahedron core and an icosidodecahedron shell. There is no
imaginary frequency in the normal vibrational modes. And combining
molecular dynamics NVT simulations the dynamic stability of the
structure is proved. The orbital bonding analysis shows that there are
multi-center bonds, twenty6-centerσ bonds and one12-centerσ bond in this
structure, which are the potential reasons for the structural stability.
Both the PDOS and the Hirshfeld charge population analysis show that
this system is non-magnetic. The HOMO frontier molecular orbital reveals
obvious s-d hybridization characteristics. In this core-shell
nanostructure, there are a large number of 1-center valence lone
electron pairs with the characteristics of d-like orbitals. This
proposed structure Au@Au makes the
size of core-shell clusters more enriched and may be used in catalysis
and medicine fields.