bluuebunny/crossref_metadata_2025_split huggingface dataset:
oldestwoodenobjects.net – A Compilation of Wooden Goods with Remarkable Longevity
Authors: Wächter Elisabeth , Grabner Michael , Mayer Konrad 
Published: April 2022

Abstract
The website oldestwoodenobjects.net serves as a platform for the scientific community to collect, display and share early traces of wood utilization. It also serves educational purposes, to teach a wide audience about how multifunctional and durable wood can be, when wisely used. The collection of objects is large and diverse, ranging from simple tools for hunting, like spears, to musical instruments of the high culture, such as violins. The first means of transport, dugout canoes or early infrastructure, like water wells, are remarkably old. Due to weathering, early buildings or constructions are poorly or only partially preserved. But some sacred buildings that are still in use today have an impressive age. At the time of writing this manuscript, a total of 211 prehistoric and historic wooden objects from around the globe were gathered and can be compared at the online application. The oldest item on the list is from 300 000 years before present. To continue expanding the database, the community is encouraged to contribute new entries.
Quality of Life After Modified Rambo Ear Canal Closure in Pediatric and Adult Patients
Authors: You Peng , Lovin Benjamin D. , Patel Akash J. , Hosek Kathleen E. , Peng Angela , Sweeney Alex D. 
Published: April 2022

AbstractObjectiveTo present the surgical and quality of life (QOL) outcomes of patients who underwent blind sac closure of the external auditory canal (EAC) via a modified Rambo approach.Study DesignRetrospective case review.SettingTertiary academic referral center.MethodsAll patients who underwent EAC closure with a modified Rambo approach between 2015 and 2021 were evaluated. Complication rates, QOL estimations from a validated survey, and subjective cosmetic reports were analyzed.ResultsThirty‐five ears were closed in 31 patients. The most common indication for surgery was related to cochlear implantation and cochlear malformation or cholesteatoma (31.4%). No case involved an immediate complication requiring revision surgery, and 4 ears (11.4%) were suspected of having cholesteatoma within the surgical cavity at a mean 28.6‐month follow‐up. Adults (≥18 years) had significantly higher QOL scores than children in the medical resource subscale of the Chronic Ear Survey (P < .01), and patients undergoing concurrent EAC closure and skull base tumor removal scored higher than others (P = .04). Females reported higher cosmetic scores than males (P = .04). QOL and cosmetic scores compared favorably to previously published data involving the management of otologic disease.ConclusionsEar canal closure can be a useful technique for select adult and pediatric patients. Patient and surgeon concerns regarding QOL and cosmesis in ear canal closure should be explored prior to employing this surgical technique, though the present data suggest that the modified Rambo approach to closure is generally associated with reasonable outcomes in both areas.
“Hero,” a virtual program for promoting prosocial behaviors toward strangers and empathy among adolescents: A cluster randomized trial
Authors: Mesurado Belén , Resett Santiago , Oñate María E , Vanney Claudia 
Published: April 2022

This study aimed to explore the effectiveness of the virtual Hero program on the promotion of empathy (emotional contagion, emotional recognition, and perspective taking) and prosocial behavior toward strangers. Moreover, we studied whether promoting empathy strengthened the program’s impact on adolescents’ prosocial behavior. The study included 431 adolescents in the intervention group ( Mage = 13.64, 47% of participants identified as cisgender men, and 53% of participants identified as cisgender women) and 325 participants in the waitlist control group ( Mage = 13.22, 47% of participants identified as cisgender men, and 53% of participants identified as cisgender women). The adolescents lived in the urban zone of Buenos Aires, Argentina. Participants completed measures of prosocial behavior and empathy. The intervention included seven weekly online sessions (a pretest evaluation, five intervention sessions, and a posttest evaluation) of approximately 40 minutes each, while the control group completed only the pretest and posttest evaluations. The research findings show that the Hero virtual program was effective in promoting prosociality directly (when not mediated by emotional contagion and emotional recognition) and indirectly through emotional contagion and emotional recognition. In addition, the Hero program promoted emotional contagion and emotional recognition, but it was not effective at promoting perspective taking. In conclusion, internet-based interventions could play a prominent role in promoting positive behavior among young adolescents.
The epidemiology of airplane headache: A cross-sectional study on point prevalence and characteristics in 50,000 travelers
Authors: Konrad Fabian , Moritz Andreas , Moritz Michael , Keunecke Johann Georg , Tischler Felix , Prottengeier Johannes 
Published: April 2022

BackgroundThe current knowledge on the epidemiology and clinical manifestation of airplane headache is mostly derived from case series and small cohort studies without evidence from large populations.MethodsThis cross-sectional study was conducted over a five-month period in the arrival area of two international airports in Germany. 50,000 disembarking passengers were addressed about headaches during their flight to determine headache prevalence, and those confirming and willing to participate underwent a structured interview.ResultsHeadache during travel was reported by 374 passengers (0.75%), and 301 underwent a structured interview. One hundred and one (0.2%) met the diagnostic criteria of airplane headache. Six passengers suffered from migraines and 134 from tension-type headaches. The differences in the age and gender distribution between the airplane headache and non-airplane headache groups were not statistically significant. The onset (79.2%), duration (82.2%), and location (73.3%) of airplane headache mostly complied with current diagnostic criteria but pain intensity (42.6%) and quality (42.6%) did less so.ConclusionOur data suggest a substantially lower prevalence of airplane headaches than previously reported. The pain intensity and quality seem less characteristic than assumed, suggesting a need to refine the current diagnostic criteria.
A Novel Model of Hip Femoroacetabular Impingement in Immature Rabbits Reproduces the Distinctive Head-Neck Cam Deformity
Authors: Kamenaga Tomoyuki , Haneda Masahiko , Brophy Robert H. , O’Keefe Regis J. , Clohisy John C. , Pascual-Garrido Cecilia 
Published: April 2022

Background: Femoroacetabular impingement (FAI) is a leading cause of hip pain in young adults and often leads to degenerative osteoarthritis (OA). A small animal model of hip deformities is crucial for unraveling the pathophysiology of hip OA secondary to FAI. Purposes: To (1) characterize a new minimally invasive surgical technique to create a proximal femoral head–neck deformity in a skeletally immature rabbit model and (2) document the effect of an injury to the medial proximal femoral epiphysis on head–neck morphology at 28 days after the injury. Study Design: Controlled laboratory study. Methods: Six-week-old New Zealand White rabbits (n = 10) were subjected to right hip surgery, with the left hip used as a control. An epiphyseal injury in the medial femoral head was created using a 1.6-mm drill. Hips were harvested bilaterally at 28 days after surgery. Alpha and epiphyseal shaft angles were measured on radiographs. Alpha angles at the 1- and 3-o’clock positions were measured on the oblique axial plane of micro–computed tomography images. Bone bar formation secondary to growth plate injuries was confirmed using alcian blue hematoxylin staining. Results: All hips in the study group showed a varus–type head-neck deformity, with lower epiphyseal shaft angles on anteroposterior radiographs versus those in the control group (133°± 8° vs 142°± 5°, respectively; P = .022) and higher epiphyseal shaft angles on lateral radiographs (27°± 12° vs 10°± 7°, respectively; P < .001). The mean alpha angles in the study group were higher at both the 1- (103°± 14° vs 46°± 7°, respectively; P < .002) and 3-o’clock (99°± 18° vs 35°± 11°, respectively; P < .002) positions than those in the control group. Alcian blue hematoxylin staining of all hips in the study group indicated that the injured physis developed a bony bar, leading to growth plate arrest on the medial femoral head. Conclusion: The proposed model led to growth arrest at the proximal femoral physis, resulting in a femoral head–neck deformity similar to human FAI. Clinical Relevance: Our novel small animal model of a femoral head–neck deformity is a potential platform for research into the basic mechanisms of FAI disease progression and the development of disease–modifying therapies.
In vitro safety and efficacy evaluation of a novel hybrid bioartificial liver system with simulated liver failure serum
Authors: Feng Lei , Wang Yi , Liu Shusong , He Guolin , Cai Lei , Qin Jiasheng , Xu Xiaoping , Jiang Zesheng , Zhou Chenjie , Gao Yi 
Published: April 2022

Background: Acute liver failure (ALF), which can potentially be treated with an artificial liver, is a fatal condition. The purpose of this study was to evaluate the safety and effectiveness of a novel hybrid bioartificial liver system (NHBLS) using simulated liver failure serum in vitro. Methods: The bioreactor in experimental group was cultivated with primary porcine hepatocytes, whereas in control group was not. Next, the simulated liver failure serum was treated using the NHBLS for 10 h. Changes in albumin (ALB), total bilirubin (TBIL), ammonia (Amm), total bile acid (TBA), creatinine (Cr), and blood urea nitrogen (BUN) were measured before treatment (0 h) and every 2 h during treatment. In addition, changes in NHBLS pressures, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lidocaine metabolism were also recorded. Results: The NHBLS worked steadily without unexpected occurrences during the treatment. Blood culture showed no bacterial growth after 7 days, and the endotoxin level was less than 0.5 EU. The TBIL, TBA, Cr, and BUN levels in both groups were markedly lower than those at 0 h ( p < 0.05). The Amm level in experimental group was significantly lower than that in control group ( p < 0.05). NHBLS pressures were also stable, and the hepatocytes in the bioreactor functioned well. Conclusions: The preparation method for the simulated liver failure serum was optimized successfully, and the safety and effectiveness of the NHBLS in vitro were verified. Furthermore, the NHBLS significantly reduced the levels of Amm which can lead to hepatic encephalopathy.
The Multi-Caregiver Role and Its Relationship to Behavioral Adherence and Weight Among Treatment Engaged Black Women
Authors: Blackman Carr Loneke T. , Samuel-Hodge Carmen D. , Tate Deborah F. 
Published: April 2022

Purpose To examine the relationship between the multiple caregiver role and its perceived barriers to self-care on behavioral adherence in a weight loss intervention. Design A secondary analysis of data from a behavioral weight loss intervention. Setting The study was conducted in two cohorts from March 2016 to February 2017 at the University of North Carolina at Chapel Hill. Subjects Eighty-one Black women with overweight/obesity (age = 48.4 ± 10.9 years [M ± SD], BMI = 36.4 ± 4.5 kg/m2 [M ± SD]). Measures Identification with the multiple caregiver role and barriers was assessed with the Multiple Caregiving Measurement Instrument. Weight was measured with a digital scale and height with a stadiometer. The Block food frequency questionnaire evaluated dietary intake. Moderate-to-vigorous physical activity (MVPA) was measured objectively with an accelerometer. Study adherence was measured by session attendance, self-weighing, and self-monitoring (diet and physical activity) frequency. Analysis Generalized linear models were used to examine the relationship between the multiple caregiver scales and the outcomes of interest, controlling for study arm, cohort, and income. Chi-square tests tested correlations. Results Greater identification with the multiple caregiver role was associated with decreased session attendance (β = −.56 [SE = .27], P < .05) and a trend towards weight gain (β = .36, [SE = .19], P = .07). Greater multiple caregiver barriers score predicted a decrease in fruit/vegetable intake (β = −.17 [SE = .07], P < .05). All regression results are unstandardized. Negative correlations between multiple caregiver barriers and MVPA ( r = −.24, P = .06) and daily self-weighing ( r = −.19, P = .10) approached significance. Conclusions Participants’ identification with multiple caregiving role and barriers can reduce adherence, behavior and weight change. Interventions to address Black women’s multiple roles and barriers during weight loss are needed to maximize outcomes.
Colostrum Use and the Immune System of Premature Newborns: A Systematic Review and Meta-Analysis
Authors: Colonetti Tamy , de Carvalho Florêncio Isabela , Figueiredo Pâmela , Colonetti Laura , Rodrigues Uggioni Maria Laura , da Rosa Maria Inês , Ceretta Luciane B. , Roever Leonardo , Grande Antonio Jose 
Published: April 2022

Background: Human colostrum has been used in a number of investigations when preterm human infants cannot, for any reason, breastfeed directly from their mothers. One of the growing fields in these investigations is colostrum therapy, which consists of exposing the oropharyngeal mucosa of these preterm newborns to small amounts of raw colostrum. Research Aim: To critically review the scientific evidence about colostrum therapy in premature infants and to explore its influences on the immune system. Methods: This systematic review was performed according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA statement). The following databases were searched for potentially eligible studies up to March 10, 2021: Medline, Scopus, Web of Science, Cochrane Library, Embase. Two reviewers independently screened all titles, abstracts, and full texts for eligibility. Results: A total of 12 studies with 996 participants were included. A significant difference in lactoferrin levels in the urine was found ( SMD 0.70; 95% CI [0.03,1.36]; p = .04; I² = 65% two studies, 112 participants, very low-quality evidence). Conclusion: Colostrum seems to result in increasing lactoferrin levels in the urine of premature newborns after 1 week of intervention. Clinical Trial Registration: The study was registered at PROSPERO with the number CRD42017073624, submitted on August 9, 2017.
Investigation of flexural properties of epoxy composite by utilizing graphene nanofillers and natural hemp fibre reinforcement
Authors: Hallad Shankar A , Ganachari Sharanabasava V , Soudagar Manzoore Elahi M , Banapurmath NR , Hunashyal Anand M , Fattah Islam MR , Hussain Fayaz , Mujtaba Muhammad A , Afzal Asif , Kabir Mohammad S , Elfasakhany Ashraf 
Published: April 2022

This study aims to determine the optimum reinforcement required to attain the best combination of flexural strength of modified green composites (graphene oxide + hemp fibre reinforced epoxy composites) for potential use in structural applications. An attempt was also made for the combination of graphene and hemp fibres to enhance load-bearing ability. The infusion of hemp and graphene was made by the weight of the base matrix (epoxy composite). Results showed that graphene reinforcement at 0.4 wt.% of matrix showed load-sustaining capacity of 0.76 kN or 760 MPa. In the case of hemp fibre reinforcement at 0.2 wt.% of the matrix, infusion showed enhanced load-bearing ability (0.79 kN or 790 MPa). However, the combination of graphene (0.1 wt.% graphene nanofillers) and hemp (5 wt.% hemp fibre) indicated a load-sustaining ability of 0.425 kN or 425 MPa, whereas maximum deflection was observed for specimen with hemp 7.5 % + graphene 0.2 % with 1.9 mm. Graphene addition to the modified composites in combination with natural fibres showed promising results in enhancing the mechanical properties under study. Moreover, graphene-modified composites exhibited higher thermal resistance compared to natural fibre reinforced composites. However, when nanofiller reinforcement exceeded a threshold value, the composites exhibited reduced flexural strength as a result of nanofiller agglomeration.
Targeted chemotherapy in retinoblastoma: A step forward from patient survival to globe survival
Authors: Naseripour Masood , Sedaghat Ahad , Mirshahi Reza , Abdolalizadeh Parya , Koushki Amin , Faranoush Mohammad , Ghorbani Mohammad , Kashkouli Mohsen Bahmani , Sadeghipour Alireza , Chaibakhsh Samira , Mehrvar Azim 
Published: April 2022

Background/ Objectives Despite being the most common intraocular malignancy in childhood, there is a substantial disparity between developing and developed countries in terms of patient and globe survival in retinoblastoma (Rb). The current study intends to determine patient and globe survival before and after the introduction of the new targeted treatment modalities in a developing country. Methods Medical records of 350 patients (516 eyes) with retinoblastoma referred to a tertiary referral center for Rb in Tehran, Iran, were reviewed. In order to compare patient and globe survival before and after the availability of the new treatment modalities, including intra-arterial and intravitreal chemotherapy, the patients were divided into group 1 (2001–2007) and group 2 (2008–2018) based on the calendar period of diagnosis. Results Two-hundred-twenty-three eyes of 149 patients and 293 eyes of 201 patients were categorized into groups 1 and 2, respectively. The 5-year patient survival was 97% across the current survey, and the overall survival rate was 96% in group 1 and 99% in group 2 (P = 0.08). Overall, 50% of eyes with retinoblastoma underwent enucleation, which was the primary in 63% (116/184) of the unilateral and 30% (99/322) of the bilateral cases. Primary enucleation was significantly lower in group 2 (35%) in contrast to group 1 (50%) (P < 0.001). In addition, globe survival improved significantly in the International Classification of Retinoblastoma Groups D (17% in group 1 vs. 66% in group 2, P < 0.001) and E (1% in group 1 vs. 23% in group 2 P < 0.001) during the two timelines. In enucleated eyes, despite the increased rate of prelaminar involvement in group 2 (13% vs. 2% in group 1, P = 0.003), the rate of high-risk histopathologic findings was similar between the two groups. Conclusion Similar to developed countries, the application of new targeted treatment modalities, including intra-arterial and intravitreal chemotherapy, has been associated with significantly improved globe survival in Rb patients. However, it should be noted that even with the availability of these novel treatment options, the decision for on-time enucleation should not be deferred.
Comminuted Mandibular Fractures in a Pediatric Patient: A Case Report with Review
Authors: Sharma Shivani , Mohammad Shadab , Kanna Shanthosh , Gupta Richa , Kharmawlong Reading Well 
Published: April 2022

Background and Introduction: Maxillofacial fractures are less common in children. Mandibular fractures are less in children because of the protective anatomy in them. Management of the pediatric fracture depends on the type and severity of the fracture displacement. It can vary from conservative management with acrylic splint and arch bar fixation to surgical exposure of the fracture site with internal fixation. Special consideration is needed in children for the interferences of growth and developing tooth buds while going for the surgical management. The hardware for internal fixation can be made up of either titanium or bioresorbable material. Case Presentation: Here is the presentation of a case of a 7-year-old male patient who had a history of trauma because of falling from a tractor while playing, 2 days back from reporting. He had multiple mandibular fractures with extensive soft tissue laceration. Following the emergency tracheostomy, he was managed with open reduction and internal fixation of the compound mandibular fracture. Conclusion: Displaced mandibular fractures require open reduction and internal fixation of the fractured fragments with either titanium or biodegradable hardware. Open reduction also shortens the period of intermaxillary fixation and hence reduces the possibility of the development of temporomandibular joint (TMJ) ankylosis.
Are your Faculty Onboard With Interprofessional Education (IPE)?
Authors: Skrabal Julie A. , Shutts Stacey A. , Morbach Julie K. , Stevens Paul L. , Sittner Barbara J. 
Published: April 2022

Objective: Interprofessional collaboration is crucial in providing high-quality care for patients. Professional organizations and accrediting agencies recognize the importance of interprofessional education (IPE) and have required that it be incorporated into curricula. The purpose of the study was to assess faculty, from various disciplines, attitudes, knowledge, and barriers associated with IPE. Materials and Methods: A descriptive correlational research design was used to assess attitudes, knowledge, and barriers associated with IPE among faculty at a Midwestern college of health sciences. Results: Findings indicated that faculty lacking IPE knowledge, barriers of time, motivation, and scheduling were factors that influenced IPE. Overall, faculty indicated that they were enthusiastic about participating and willing to learn. Those who attended an intervention, which consisted of an educational presentation and activity, provided statistically significant perceptions about IPE. Conclusion: These results indicate that faculty attitudes, knowledge, and barriers influenced incorporation of IPE into curricula. Key Takeaways Interprofessional education (IPE) is essential to ensure faculty have the knowledge and tools to successfully implement activities in the classroom and clinical setting. Factors that influence IPE implementation include time, scheduling, knowledge, and motivation. These factors must be addressed for successful incorporation of IPE to occur. Begin IPE incorporation with faculty champions who are more enthusiastic and willing to learn about IPE.