bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulation and Evaluation of Naproxen Orodispersible Tablets
Authors: Mhetre Raksha L , Kadam Pratiksha S , Gadhire Pradyna H , Lajurkar Gauri , Aditee D. Kagde  , Dhole Shashikant N 
Published: September 2022

Background: In the treatment of variant disease, oral administration is the main choice in society, especially in children. Orodispersible tablets have been more popular among children in recent years than oral liquid dosage forms. An Orodispersible tablet disintegrates in the oral cavity and the drug gives pharmacological and therapeutically responses as the faster onset of action.
Purpose of the study: Naproxen is a nonsteroidal anti-inflammatory drug that is used to treat mild to moderate pain and arthritis. In this study, super disintegrant agents Crospovidone and Croscarmellose Sodium were used to make Naproxen orodispersible tablets utilizing a direct compression approach.
Research rationale: The goal of this study was to develop and evaluate orodispersible naproxen tablets in order to improve their disintegration and dissolving profiles.
Method: Direct compression techniques were used to manufacture naproxen orodispersible tablets, which disintegrate in the oral cavity without the need for water in a matter of seconds when placed on the tongue.
Results: FTIR and PXRD were used to investigate the drug-excipient interaction. The pre-compression and post-compression properties of the prepared tablets were assessed. The formulated tablets show a disintegration time of 32-53 seconds with In vitro drug release of 100% within 15 minutes. Weight variation, Friability, and Hardness were all found to be within acceptable limits.
Conclusions: Naproxen orodispersible tablets containing croscarmellose sodium, crospovidone, and other excipients provide improved disintegration and a more complete drug release profile.
The Pharmacognostic Standardisation of Medicinally Important Notorious Weed-Lantana camera
Authors: Dhikale Rupali , Gulecha Vishal , Zalte Amar 
Published: September 2022

Background: The species Lantana camera is an important medicinal, ornamental, as well as essential oil-producing herb from the family Verbenaceae. It is also known as red sage and is used as a popular ornamental plant in gardens. L. camara grows in tropical, subtropical, and temperate regions at a high altitude up to 2000 m. In India, L. camera is considered a poisonous plant and included in the top ten invasive weeds. Invasive weeds are nothing but a species that is not native to the ecosystem under consideration and whose introduction causes economic or environmental harm or human harm. Due to its invasive nature, L. camera is lagging behind in the list of medicinal plants for their uses in drug preparation. However, it is listed as one of the most significant medicinal plants in the world. The plant extracts have been used in folk medicine for the treatment of cancers, chicken pox, measles, asthma, ulcers, swellings, eczema, tumors, high blood pressure, bilious fevers, and catarrhal infections, tetanus, rheumatism and malaria. Despite significant ethnomedicinal properties of L. camera few investigations have been carried out in respect of the Pharmacognostic standardization of complete plant. The work performed related to Pharmacognostic study so far is not sufficient. Therefore, the main objective of the present review is to create awareness about L. camera as one of the useful weeds in society by studying it from a pharmacognosy point of view.
Results: With respect to the above, the present work deals with the Pharmacognostic and phytochemical studies of leaves, stems and fruits of L. camera. The details study of Macroscopy, Microscopy, physicochemical and phytochemical parameters demonstrated the various diagnostic features of L. camera.
Conclusions: The overall outcome of the macroscopical, microscopical, physicochemical and phytochemical study will be helpful in the correct identification and establishment of standardization parameters for the leaves, stem and fruits of medicinally important notorious weed.
Biofilm formation by ESBL-producing uropathogenic E. coli
Authors: MEHTA MANJULA , SHARMA JYOTI , BHARDWAJ SONIA , Chawla Arshi , Ghai Akshay 
Published: September 2022

Introduction: E. coli is considered to be the leading cause of urinary tract infections. (UTIs) and is responsible for both community acquired and hospital acquired UTIs. The ability of this bacterium to form biofilm on various devices like catheters plays an important role in progression of the disease. Biofilm production in extended spectrum beta lactamases (ESBLs) producing organisms provides a favourable environment for the exchange of resistance genes and may also facilitate widespread dissemination.
Methods: The urine samples were collected from the suspected cases of urinary tract infections and were cultured on cystine lactose electrolyte deficient (CLED) agar plates to isolate the desired UPEC strains. All the isolated E. coli strains were subjected to ESBL detection by double disk approximation method and to biofilm formation by tissue culture plate method of biofilm detection. All the results were statistically analysed using k2 test with p value at <0.05 level of significance.
Results: Out of all the gram negative bacilli isolated from urine samples, E. coli alone accounted for 90% of the isolates. Of all the UPEC isolates subjected to ESBL detection 50% of the strains turned out to be the ESBL producers and 35% of the strains showed biofilm formation.
Conclusion:

The majority of the work in literature sites the data samples collected from indoor patients, where these isolates coli strains which produced ESBLs were mainly a strong biofilm former as compared to non-ESBL producer strains.
In this study in spite of all the coli strains being outpatient isolates still the correlation between ESBL production and biofilm formation holds true.
We found a significant correlation between biofilm formation and ESBL production. The detection of ESBL production and biofilm formation pattern will help in development of newer and more effective treatment.
Chernobyl. Hazard of forest fires
Authors: Боровой Александр Александрович , Гаврилов Сергей Львович , Хвощинский Валерий Александрович 
Published: September 2022

В последние годы все больше внимания обращается на последствия пожаров, возникающих в зоне отчуждения Чернобыльской АЭС. Данная проблема активно обсуждается как в специальной литературе, так и в средствах массовой информации. При этом высказываются самые различные мнения о возможности распространения радиоактивного заражения за пределы зоны отчуждения. В настоящей работе приводятся результаты прямых измерений, выполненных сотрудниками «Курчатовского института». Они позволяют оценить как реальную радиологическую опасность для людей, участвующих в борьбе с огнем, так и вероятность расползания радиоактивного пятна.
The number of fires in the Chernobyl exclusion zone has been growing in recent years, and thousands of hectares of forests are actually burning. This is due to worsening of fire conditions in forests, climate changes and a lack of fire-prevention means and fire-fighting equipment. The problem draws attention of both experts and the media. The direct measurements in the seat of a fire instead of calculated estimates become increasingly important in such conditions. Such measurements can provide information concerning danger for the involved fire fighters as well as the risk of radioactive contamination spreading beyond the exclusion zone. The results of measurements carried out by specialists of the Kurchatov Institute are presented in this paper. The level of air contamination with radionuclides at the very fire edge was determined as well as the data on transfer of radionuclides in the plume of smoke and warm air were obtained. The radiation situation for firemen fighting directly a fire requires mandatory use of individual and collective protective equipment. The use of remote extinguishing means is a better solution since the concentration of active aerosols in the fire area may exceed the permissible values by orders of magnitude. Measurements at a distance of ~2 km from the fire front revealed no noticeable advancement of contamination (about 1 kilometer) during such a fire, even in the smoke direction. As noticed experts recommend a variety of large-scale and expensive activities to prevent major fires in the exclusion zone but they are unlikely to be carried out in the near future. In such a situation early detection of the location of any fire and the use of improved fire-fighting equipment seems to be a more realistic way.
Differences in Health Literacy of Older Adults According to Sociodemographic Characteristics
Authors: Štemberger-Kolnik Tamara , Ljubič Andreja , Filej Bojana , Poredoš Mojca , Kaučič Boris Miha 
Published: September 2022

BACKGROUND: The research is based on the concept of health literacy. This is the “sixth vital sign” to navigating the healthcare system and raising self-efficacy in the field of healthcare.
AIM: The study aim was to present the health literacy of the elderly in the Savinja statistical region in Slovenia.
METHODS: The study was based on a non-experimental quantitative research approach. The study included 199 elderly people aged 65 and more, without the presence of dementia. The data were collected using the Health Literacy and Montreal Cognitive Assessment questionnaire. We used a non-random, convenience sampling.
RESULTS: We established that in the study population, 64.8 % of the population was below the level of acceptable general health literacy, whereas only 3.5 % of this population had an excellent level of health literacy. Statistically significant differences in the level of health literacy are shown in the field of healthcare treatment in older adults living with their families (F = 5,198; p ˂ 0,001). Respondents who engaged in activities in day care centres also had a higher level of health literacy (t = 3,738; p < 0,001). People with low health literacy, who use health services more frequently, should be given access to health education, based on individual presentation of contents, supported by andragogical knowledge.
CONCLUSION: The health literacy of older adults is the basis for their greater care for their own health and a better quality of life.
Four new species of ctenid spiders (Araneae, Ctenidae) from Southeast Asia, with the first description of the female of Sinoctenus zhui Marusik, Zhang &amp; Omelko, 2012
Authors: Lu Ying , Chu Chang , Yao Zhiyuan , Li Shuqiang 
Published: September 2022

The spider family Ctenidae Keyserling, 1877 has a worldwide distribution with 580 species belonging to 49 genera, of which 109 species of six genera are distributed in Southeast Asia.
Four new species of ctenid spiders are described from Southeast Asia: Anahita menglun sp. n. (Yunnan, China), Bowie haiphong sp. n. (Hai Phong, Vietnam), Bowie mengla sp. n. (Yunnan, China) and Bowie zhengi sp. n. (Yunnan, China). In addition, the female of Sinoctenus zhui Marusik, Zhang & Omelko, 2012 (Hainan, China) is described for the first time.
« Toi aussi t’en peux plus ? »
Authors: Joly Lorraine 
Published: September 2022

On ne peut pas forcément prévenir la surcharge, elle advient potentiellement. Mais les parents et les frères et sœurs peuvent inventer une manière de la penser et de la vivre pour qu’elle n’anéantisse pas tout désir, qu’elle n’aspire pas toute pulsion de vie. Et quoi de mieux pour avancer que d’y réfléchir avec d’autres, confrontés aux mêmes questionnements ? C’est l’histoire de groupes de parole pour les frères et sœurs et pour les parents que nous allons dérouler ici.
Risk Factors for Failure of Final Anatomic Surgical Reattachment in Retinal Detachments From Combat Ocular Trauma
Authors: Purt Boonkit , Justin Grant A. , Baker Katherine M. , Brooks Daniel I. , Ryan Denise S. , Sia Rose K. , Weichel Eric D. , Colyer Marcus H. 
Published: September 2022

BACKGROUND AND OBJECTIVE:
The goal of this study was to determine the anatomic outcome of traumatic retinal detachment (RD) from combat ocular trauma.

MATERIALS AND METHODS:
Retrospective study of patients sustaining a traumatic RD in Operation Iraqi Freedom and Operation Enduring Freedom who were evacuated to Walter Reed Army Medical Center from 2001 to 2011. The Fisher exact test, Wilcoxon rank sum test, and Agresti and Coull methods were used for analyses.

RESULTS:

There were 143 eyes of 134 patients in which a traumatic RD developed, of a total of 890 eyes of 652 patients in the Walter Reed Ocular Trauma Database. Based on our results, predictors for failure to reattach the retina include maculaoff status (
P
= .0002), open-globe injury (
P
= .03), proliferative vitreoretinopathy postoperatively (
P
= .002), and presence of hyphema (
P
= .02). Intraocular foreign body and time to initial retinal surgery did not increase risk for failure. Thirty-four percent (34%) of eyes failed to be reattached.

CONCLUSIONS:
Traumatic RD due to injury sustained in a combat zone resulted in poor prognosis, with 82.09% of eyes with RD having a best-corrected visual acuity worse than 20/200. The anatomic success of RD repair was shown to be 65.71%, likely owing to the severity of the injuries, concomitant systemic injuries, and delayed surgical intervention.

[
Ophthalmic Surg Lasers Imaging Retina
2022;53:493–501.]
Design Creativity as the way of dealing with students’ stress in the context of the global pandemic challenge
Authors: Skliarenko Nataliia , Kolosnichenko Olena , Rohotchenko Oleksii , Kolosnichenko Marina , Chykhurskyi Anatolii 
Published: September 2022

In this publication we concentrate our attention on finding the ways for dealing with students’ stress during the COVID-2019 pandemic period and implementing them into the constant practice. In the design practice we can consider stress not only as negative, but also positive experience. We present our own experience that unites educational technologies in the design practice, the design-methods and some moments of the art therapy. We examine students’ diploma projects simultaneously as the design-product and the design-process that have anti-stress effect and are the method of harmonization of the students’ internal world in terms of the changeable medium. We consider different ways of art visualization as the mechanism of self-actualization, decrease of anxiety and dealing with depressive conditions. The work outlines the strategy of using design creativity as the way of overcoming and preventing the effects of stress factors during studying in the context of global pandemic challenges.
Keywords: Anti-Stress Processes, Anti-Stress Products, Design Creativity, Design Thinking, Educational Technologies.
Burden of Acquired Thrombotic Thrombocytopenic Purpura
Authors: AAL-Yaseen Hasan , Al Mehairi Amna , Aldarweesh Mohammed , Damlaj Moussab , El Tayeb Khaled , Hussain Sabir , Osman Hani , Almomen Abdulkareem M. , Marashi Mahmoud 
Published: September 2022

BACKGROUND:
In Saudi Arabia (KSA) and the United Arab Emirates (UAE), only limited epidemiological data and treatment guidance exist for acquired thrombotic thrombocytopenic purpura (aTTP), a rare, life-threatening blood disorder.

AIMS:
Expert insights from KSA and UAE were used to obtain local epidemiological data, to characterize current disease management and unmet needs, and to formulate recommendations for the improvement of the diagnosis and treatment of aTTP. Costs and socioeconomic burden were a secondary focus.

METHODS:
Hematologists from KSA and UAE with clinical experience in the diagnosis and management of aTTP individually answered questions on the burden and management of aTTP via an online survey. Based on these insights, a draft consensus was discussed and refined jointly by the hematologists in a live session for each country. Payers provided information on the economic burden and cost of aTTP management.

RESULTS:
The experts estimate the incidence of aTTP to 5–6 (KSA) and 1–2 (UAE) per 1,000,000 person-years and anticipate it increasing. Most of the presenting patients are aTTP-naive. Recurrent disease is rare. Diagnosis of aTTP should involve ADAMTS13 activity testing. Plasma exchange and immunosuppression are the current standard of care. Key unmet needs include a lack of awareness of aTTP, access to rapid testing and novel treatments to improve outcomes.

CONCLUSION:
The expert consensus to address the unmet needs and improve aTTP outcomes include increasing aTTP awareness and access to ADAMTS13 testing; the development of national guidelines; and, additionally, strategies to improve patients' long-term quality of life.
Biocidal effects of dennettia tripetala, zingiber officinale and benlate on seedborne fungal pathogen (fusarium moniliforme) of watermelon (citrullus lanatus) varieties.
Authors: Christian C., Iwuagwu, , Bernadine E., Ndife , Uwaoma O. Aguwa, , Donald E., Iheaturu, , Oluropo A., Apalowo, , Mary-Geraldine E Ejiofor, , Doris C., Iwu, 
Published: September 2022

This study was carried out to investigate the effect of plant extracts, African pepper fruit (Dennettia tripetala) and Ginger (Zingiber officinale) on seed borne fungal pathogens of Watermelon (Citrullus lanatas) seeds. Watermelon seeds were extracted for seed health test using blotter paper method. The antifungal effects of ethanol and acetone extracts of the two plant extracts and synthetic fungicide were studied under in- vitro experiment against the seed borne fungal pathogen of Watermelon at 0%, 50% and 75%. It was a 3x3 factorial experiment at 5% Probability level laid out in a Completely Randomized Design experiment with three replications Ninety percent germination was obtained in the germination and seed health test of Watermelon seeds. Seed borne fungal pathogen (Aspergillus spp. and Fusarium spp.) were identified. The potential of these organisms for pathogenicity were tested using Kock’s postulate. The result of the pathogenicity test showed that Fusarium spp. was pathogenic. All plant extracts and Benlate inhibited the fungus (Fusarium moniliforme) in culture. The inhibition was also greater as concentration increased from 50% to 75%. It was also observed that ethanol extraction solvent did better than acetone. Generally, Dennettia tripetala extract performed better than Zingiber officinale. It could therefore be recommended that the two plant extracts used in this investigation which were very effective in the control of Fusarium moniliforme of watermelon could be an alternative to the synthetic fungicide. It could also be suggested that further studies be carried out to isolate, identify, characterize and standardize the bioactive components of these phytochemicals in a bid to commercializing their production.
The Issuing of the Sukuk Framework in Afghanistan and Its Contribution to Economic Development
Authors: Heravi Farid Ahamd 
Published: September 2022

This article aims to provide an essential and significant proposal for the Sukuk issuance framework and explore its necessity in Afghanistan, to be Consistent with Shariah’s requirements and in light of the other Muslim country's experiences, especially Malaysia. The problem is, how can Afghanistan increase its economic development by issuing sukuk, and struggle against poverty and unemployment, and what are the advantages of sukuk on the financial dimension of Afghanistan? The article is divided into two axes. Accordingly, the first axis of this article focused on the general analysis of Sukuk and contains the Islamic worldview of Sukuk, the concept of Sukuk, the basic principles of Sukuk, requirements of Sukuk, benefits of sukuk, common types of Sukuk, securitization, and the most important distinctions between Sukuk and conventional bonds. The second axis gives information on how Sukuk can be issuance in Afghanistan and its regulatory framework, and legal and economic challenges, and provides suggestions for overcoming these obstacles as well. It investigates the remarkable impact of Sukuk on economic growth in Afghanistan in all aspects such as (GDP) Gross Domestic Product, (GCF), Gross Capital Formation, poverty eradicating, unemployment reduction, obtaining an independent financial system, prevention of budget shortfalls, contribution economic development. The data were collected from primary sources such as a questionnaire which has been conducted between the scholars and experts of Islamic financing, and secondary resources such as books, publications, websites, and official reports. Consequently, the findings showed that Sukuk financing will have an extraordinary impact on the Afghanistan economic system like its remarkable influences on economic growth for (SEAC) countries of south Asia, and (GCC) The Gulf Cooperation Council countries, therefore the searcher suggests securitization in Afghanistan as well for financing growth and economic development
The hórreos in Riaño Mountain, León, Spain. Vernacular architecture between conservation and musealisation
Authors: García Cuetos María Pilar 
Published: September 2022

Hórreos, aerial or raised barns, constitute a very singular typology of vernacular architecture. The guardianship of Spanish hórreos began with their recognition as personal properties in 1926. In 1973, all the hórreos and paneras in Asturias and Galicia were placed under state pro-tection. Later, the autonomous laws included its preservation. In 1984 an order that protected the Leonese hórreos was approved. However, this legislative protection was useless when the Remolina reservoir, which flooded several towns in the region of Riaño Mountain – León, Spain – was built in 1985.The value of traditional architecture and the hórreos in the villages of the Riaño Mountain was claimed by architects such as Leopoldo Torres Balbás or Manuel Cárdenas. The disappearance of many of them has meant an irreparable loss of a unique type of vernacular architecture. When it came to deciding which elements should be saved from the destruction caused by the reservoir, vernacular architecture was neglected. One of the hórreos was dismantled and remounted in Nuevo Riaño, the new settlement built to replace the disappeared village. Isolated from its con-text, it became a museum element, perceived as a cultural relic.At the beginning of the 20th century, the council of Riaño became aware of how valuable these elements are and proposed the recovery of the constructive techniques and traditions related to Leonese hórreos. In 2014 a new one was built and placed in Nuevo Riaño square. Surrounded by buildings that have nothing to do with the vernacular architecture in the territory and decon-textualised, it is perceived as something beyond to the present days. Today, 142 hórreos are preserved in Riaño Mountain and they must be kept as something more than cultural relics and, additionally, the constructive traditions linked to them must be preserved.