bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibiting the DNA damage response pathway promotes functional recovery after spinal cord injury
Authors: Ahmed Zubair , Tuxworth Richard I. 
Published: July 2022

AbstractSpinal cord injury (SCI) affects up to 1.26 million people every year, leading to permanent disability and death. The biggest causes of SCI are motor vehicle accidents, falls and interpersonal violence with clinical outcomes very much dependent on the severity and location of the lesion. Frequently, there is loss of motor or sensory function below the level of injury. At present, there are no restorative treatments for SCI patients, with only palliative treatments on offer and complicated further by the low intrinsic capacity of the central nervous system to regenerate. A recent study by Tuxworth and Ahmed, published in Clinical and Translational Medicine1 shows that inhibiting ataxia‐telangiectasia mutated (ATM) kinase, a central regulator of the DNA damage response pathway, promoted axon regeneration and remarkable improvements in sensory and motor function after SCI in both mice and rats. Moreover, the ATM inhibitor, AZD1390, is potent and highly selective, orally bioavailable and brain‐penetrant.2 AZD1390 is currently being developed for the treatment of brain cancers but with its simple route of administration (oral), has the potential to be re‐purposed for use in SCI.
Applications of single‐cell multi‐omics sequencing in deep understanding of brain diseases
Authors: Zhang Xu , Lu Ping , Shen Xiaorong 
Published: July 2022

AbstractIntroductionThe mammalian brain consists of intricate neural networks of millions to billions of highly differentiated and interconnected cells. Single‐cell sequencing (SCS), a newly developed technology, revolutionises our comprehension of the genomic, transcriptomic, proteomic and epigenomic landscapes of cells within the brain. With single‐cell sequencing technology, it's possible to profile brain cell type diversity, to elucidate the specific function, connectivity and state of brain cells and to reveal the neural complexity, functional organisation and dynamics of the brain, which provides novel data sources for exploration of brain development and diseases.MethodsIn this review, we described current single‐cell‐based methodologies used for single‐cell sequencing technology, and then summarised recent applications of this cutting‐edge technology in brain research, including cellular heterogeneity, development and disease mechanisms of the brain.ResultsSingle‐cell sequencing (SCS) has substantially advanced our knowledge of brain functions and diseases by enhancing the resolution of diverse cell subpopulations within the brain, identifying novel gene signatures and cell markers and shedding light upon functional differences and developmental trajectories.ConclusionDespite a large amount of work remains to be accomplished due to the complexity of the brain and the vast amount of single‐cell data, the prospects of single‐cell sequencing in deciphering brain intricacy and facilitating molecular/clinical/earlier diagnosis, targeted treatment, therapy assessment and prognosis of a wide range of brain diseases are promising.
Palaeocene to Miocene southern Tethyan carbonate factories: A meta‐analysis of the successions of South‐western and Western Central Asia
Authors: Coletti Giovanni , Commissario Lucrezi , Mariani Luca , Bosio Giulia , Desbiolles Fabien , Soldi Mara , Bialik Or M. 
Published: July 2022

AbstractOne hundred and forty‐four published successions of shallow‐water carbonates, deposited between the Palaeocene and the Miocene, from the Levant to the Himalayas, have been re‐analysed using a standardised approach to investigate the distribution of carbonate facies and carbonate‐producing organisms. Large benthic foraminifera were found to be the volumetrically most important group of carbonate producers during the whole period, with a peak in abundance during the Eocene. Colonial corals are relatively abundant during the Palaeocene and Miocene, their abundance peaks during the Oligocene and has a minimum during the Eocene. Red calcareous algae have a similar pattern although their peak in abundance covers both the Oligocene and Miocene. Green calcareous algae decrease from the Palaeocene onward. Facies related to very shallow and/or restricted marine conditions peak during the Miocene and in particular during the Aquitanian. Both the pattern of large benthic foraminifera and of colonial corals seems to be related to temperature, with warm periods favouring the former group and cool periods the latter group. Red calcareous algae display a pattern similar to that of colonial corals suggesting that the periods favourable for one group are, on a large scale, also favourable for the other. The progressive decrease of green calcareous alga could be tentatively related to a preservation bias connected to the transition from Palaeogene assemblages that included presumably calcitic taxa of green algae to Neogene assemblages entirely constituted by aragonitic taxa with limited preservation potential. The Aquitanian peak in facies related to very shallow and/or restricted marine conditions is most likely connected to the progressive narrowing of the Tethys related to the collision between Arabia and Eurasia. These results denote an overall agreement between the abundance of the various types of shallow‐water carbonate facies and large‐scale environmental and geological processes, highlighting the potential for palaeoenvironmental reconstruction locked in the shallow‐water record.
Monitoring resistance and resilience using carbon trajectories: Analysis of forest management–disturbance interactions
Authors: Davis Thomas S. , Meddens Arjan J. H. , Stevens‐Rumann Camille S. , Jansen Vincent S. , Sibold Jason S. , Battaglia Mike A. 
Published: July 2022

AbstractA changing climate is altering ecosystem carbon dynamics with consequences for natural systems and human economies, but there are few tools available for land managers to meaningfully incorporate carbon trajectories into planning efforts. To address uncertainties wrought by rapidly changing conditions, many practitioners adopt resistance and resilience as ecosystem management goals, but these concepts have proven difficult to monitor across landscapes. Here, we address the growing need to understand and plan for ecosystem carbon with concepts of resistance and resilience. Using time series of carbon fixation (n = 103), we evaluate forest management treatments and their relative impacts on resistance and resilience in the context of an expansive and severe natural disturbance. Using subalpine spruce–fir forest with a known management history as a study system, we match metrics of ecosystem productivity (net primary production, g C m−2 year−1) with site‐level forest structural measurements to evaluate (1) whether past management efforts impacted forest resistance and resilience during a spruce beetle (Dendroctonus rufipennis) outbreak, and (2) how forest structure and physiography contribute to anomalies in carbon trajectories. Our analyses have several important implications. First, we show that the framework we applied was robust for detecting forest treatment impacts on carbon trajectories, closely tracked changes in site‐level biomass, and was supported by multiple evaluation methods converging on similar management effects on resistance and resilience. Second, we found that stand species composition, site productivity, and elevation predicted resistance, but resilience was only related to elevation and aspect. Our analyses demonstrate application of a practical approach for comparing forest treatments and isolating specific site and physiographic factors associated with resistance and resilience to biotic disturbance in a forest system, which can be used by managers to monitor and plan for both outcomes. More broadly, the approach we take here can be applied to many scenarios, which can facilitate integrated management and monitoring efforts.
Prognosis value of Forrester's classification in advanced heart failure patients awaiting heart transplantation
Authors: Baudry Guillaume , Coutance Guillaume , Dorent Richard , Bauer Fabrice , Blanchart Katrien , Boignard Aude , Chabanne Céline , Delmas Clément , D'Ostrevy Nicolas , Epailly Eric , Gariboldi Vlad , Gaudard Philippe , Goéminne Céline , Grosjean Sandrine , Guihaire Julien , Guillemain Romain , Mattei Mathieu , Nubret Karine , Pattier Sabine , Pozzi Matteo , Rossignol Patrick , Vermes Emmanuelle , Sebbag Laurent , Girerd Nicolas 
Published: July 2022

AbstractAimsThe value of Forrester's perfusion/congestion profiles assessed by invasive catheter evaluation in non‐inotrope advanced heart failure patients listed for heart transplant (HT) is unclear. We aimed to assess the value of haemodynamic evaluation according to Forrester's profiles to predict events on the HT waitlist.Methods and resultsAll non‐inotrope patients (n = 837, 79% ambulatory at listing) registered on the French national HT waiting list between 1 January 2013 and 31 December 2019 with right heart catheterization (RHC) were included. The primary outcome was a combined criteria of waitlist death, delisting for aggravation, urgent HT or left ventricular assist device implantation. Secondary outcome was waitlist death. The ‘warm‐dry’, ‘cold‐dry’, ‘warm‐wet’, and ‘cold‐wet’ profiles represented 27%, 18%, 27%, and 28% of patients, respectively. At 12 months, the respective rates of primary outcome were 15%, 17%, 25%, and 29% (P = 0.008). Taking the ‘warm‐dry’ category as reference, a significant increase in the risk of primary outcome was observed only in the ‘wet’ categories, irrespectively of ‘warm/cold’ status: hazard ratios, 1.50; 1.06–2.13; P = 0.024 in ‘warm‐wet’ and 1.77; 1. 25–2.49; P = 0.001 in ‘cold‐wet’.ConclusionsHaemodynamic assessment of advanced HF patients using perfusion/congestion profiles predicts the risk of the combine endpoint of waitlist death, delisting for aggravation, urgent heart transplantation, or left ventricular assist device implantation. ‘Wet’ patients had the worst prognosis, independently of perfusion status, thus placing special emphasis on the cardinal prominence of persistent congestion in advanced HF.
Aerosol Assisted Synthesis of Y/ZSM‐5 Composite Zeolite and Its Application in Cracking Reaction
Authors: Xiong Guang , Zhou Shengyang , Liu Liping , Qian Ji , Liu Jiaxu , Zhao Leping 
Published: July 2022

AbstractY/ZSM‐5 composite zeolite was synthesized by an aerosol assisted hydrothermal method including a two‐step crystallization. The aerosol technique was used to prepare the precursor of Y/ZSM‐5 composite zeolite. This helped to fully utilize the amorphous silica‐alumina species left in the primary crystallization solution of NaY zeolite, and to bring the two zeolites close to each other during the second crystallization step. The optimal adding sequence and synthesis conditions were investigated to reduce the amount of template and accelerate the crystallization rate. The composite zeolites were analyzed using XRD, SEM, nitrogen physical adsorption, NH3‐TPD techniques. It was found that the acid properties can be adjusted by modulating the SiO2/Al2O3 molar ratio of the secondary crystallization feed. The BET specific surface area of the optimal Y/ZSM‐5(20) composite zeolite is 502 m2/g, the pyrolysis conversion rate of 1,3,5‐triisopropylbenzene reaches 95.1 %, and the selectivity to benzene reaches 53.4 %.
Enantioselective Synthesis of α,β‐Unsaturated Aryl Lactams by Heck‐Matsuda and Heck‐Mizoroki Arylations of Enelactams
Authors: Bastos Braga Ingredy , Almir Angnes Ricardo , Carlos de Lucca Júnior Emilio , Carmo Braga Ataualpa Albert , Roque Duarte Correia Carlos 
Published: July 2022

AbstractThe chiral aryl lactam nucleus is a common motif present in many bioactive natural products and the development of effective enantioselective methodologies for its preparation is of great interest. In this work, we report the synthesis of several enantioenriched aryl lactams in good yields and enantiomeric ratios using a combined strategy employing arenediazonium salts bearing electron‐withdrawing substituents, aryl iodides with electron‐donating substituents, and chiral N,N‐ligands. The chiral α,β‐unsaturated aryl lactams were obtained in yields of up to 78 % and enantiomeric ratios up to 95 : 5. Furthermore, this work demonstrates the use of chiral N,N‐ligands as a viable alternative to the phosphine‐based ligands in the enantioselective Heck‐Mizoroki reactions using aryl iodides. The origins of the enantioselectivity and the full catalytic cycle for the Heck‐Matsuda arylation of the enelactams were investigated through DFT calculations.
7,12‐Dihydrobenzo[de]indolo[3,2‐b]quinoline: Unique Reactivity and Redox Interconversion
Authors: Fujimoto Keisuke , Sasaki Kentaro , Yamagishi Shota , Inuzuka Toshiyasu , Sanada Kazutaka , Sakamoto Masami , Takahashi Masaki 
Published: July 2022

AbstractAcetyl‐substituted 7,12‐dihydrobenzo[de]indolo[3,2‐b]quinoline was developed as a N‐substituted polycyclic heteroaromatic molecule via Pd‐catalyzed cyclo‐isomerization of an alkyne precursor, followed by intramolecular Goldberg amination. This compound showed unique reactivity, notably, base‐mediated deacylative oxygenation and photo‐Fries rearrangement. A series of products exhibited characteristic electronic properties based on the redox state of the corresponding nitrogen atoms. The photo‐rearranged product, which possesses a 1,2‐diaminoethene substructure, akin to the redox functionality of the natural flavin adenine dinucleotide, underwent reversible interconversion with the corresponding oxidized form. The efficient stabilization of the highly electron‐rich 7,12‐dihydrobenzo[de]indolo[3,2‐b]quinoline skeleton was ascribed to the electron‐withdrawing effect, intramolecular hydrogen bonding of the acetyl group, and local aromatic stabilization in the indole moiety.
Psychosocial factors associated with pain and health‐related quality of life in Endometriosis: A systematic review
Authors: Kalfas Michail , Chisari Claudia , Windgassen Sula 
Published: July 2022

AbstractBackground and ObjectiveEndometriosis is associated with pain and impaired health‐related quality of life (HRQoL). Psychosocial factors have been associated with pain and HRQoL in other conditions, suggesting their potential relevance in Endometriosis. However, the role of psychosocial factors in this population has not been systematically explored yet. This systematic review aims to explore the association of psychosocial factors with pain intensity/severity and HRQoL in women with Endometriosis.Databases and Data TreatmentObservational and experimental studies that explored the association of psychosocial factors with pain and HRQoL in women with Endometriosis were eligible. The following databases were searched: Medline, Embase, Cochrane library, Web of Science, PsychInfo and Cumulative index of nursing and allied health literature. The methodological quality was assessed, and findings were synthesized using narrative synthesis.ResultsTwenty‐seven studies were eligible for inclusion, which included 5419 women with Endometriosis. Catastrophising and anxiety were the factors most consistently associated with greater pain, whilst depression, anxiety and stress were related to worse HRQoL. Findings regarding depression and pain were mixed, and research on social factors was limited.ConclusionsThis systematic review highlights the role of psychosocial factors in Endometriosis. Anxiety, depression and catastrophising are suggested as potential treatment targets. The review also indicates the lack of research on other potentially important psychosocial factors, such as avoidance, perceived injustice and social support.SignificanceThis systematic review explored the role of psychosocial factors in Endometriosis, suggesting that these are associated with pain and health‐related quality of life (HRQoL). Among the psychosocial factors included, anxiety, depression and catastrophising were the factors most often associated with pain and HRQoL in Endometriosis. These findings highlight the need to target psychological factors in the treatment of women with Endometriosis.
Experimental study of the influence of temperature and cooling method on dynamic mechanical properties and damage of granite
Authors: Xi Yan , Wang Haoyu , Zha Chunqing , Li Jun , Guo Boyun 
Published: July 2022

AbstractThe change in mechanical properties of high‐temperature rock after cooling treatments is getting increasing attention. However, only a few studies have been conducted on the dynamic characteristic parameters. Therefore, this study aims to perform a dynamic damage analysis of high‐temperature rocks subjected to different thermal shocks. Accordingly, the specimens were grouped and heated to 200°C, 400°C, 600°C, and 800°C, and they were cooled by natural, water, and liquid nitrogen cooling. Ultrasonic detector tests, the split Hopkinson pressure bar experiments, and scanning electron microscope tests of the high‐temperature granite specimens were conducted using different cooling methods. Subsequently, the change rules of dynamic stress–strain curves and properties were calculated, and the morphology and micromorphology of fragments were compared. Based on the outcomes, the thermal shock damage and impact damage evolution were evaluated and quantified. The findings revealed that when the treatment temperature increases, the dynamic peak stress and elastic modulus decrease, while the peak strain increases, and the effect of rapid cooling was more significant in the influence of rock dynamic characteristics. Moreover, when the damage factor is more than 0.51, the change of dynamic stress‐strain is accelerated, leading to the instability of the structure under the impact load. The research results are expected to provide an adequate theoretical basis for the development and utilization of geothermal resources and underground engineering applications.
Evaluation of different agricultural wastes for the production of polysaccharides from Oudemansiella raphanipes and its antioxidant properties
Authors: Wei Qi , Zhong Xinrong , Haruna Maryam Hajia , Liu Shengrong , Zhou Fengfang , Chen Meixia 
Published: July 2022

AbstractOudemansiella raphanipes (OR) is a commercial mushroom which possesses high nutritional value and excellent and unique flavors. In this study, various agricultural wastes were utilized as substitute materials in the low‐cost and high‐yield production of mycelia biomass and polysaccharides by liquid fermentation. The sawdust, wheat bran, apple pomace, sugarcane, and corn particles were employed to cultivate OR, using the potato dextrose broth as control. Additionally, a preliminary characterization and in vitro antioxidant activities of partial purified OR polysaccharides were investigated. The substrate of sugarcane was suitable for mycelia growth of OR, with high yield of mycelia biomass and polysaccharides content. In vitro antioxidant activity assays demonstrated that OR polysaccharides could effectively scavenge 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) and 1,1‐diphenyl‐2‐picrylhydrazyl radicals. OR polysaccharides had configuration as revealed by Fourier transform infrared, and was mainly composed of fucose (Fuc), rhamnose (Rha), arabinose (Ara), galactose (Gal), glucose (Glc), xylose (Xyl), mannose (Man), ribose (Rib), and galacturonic acid (Gal‐UA), with mass percentages of 3.29%, 0.64%, 1.09%, 16.03%, 72.69%, 0.56%, 3.18%, 0.93%, and 1.59%, respectively. This study may offer support for decreasing the cost of OR polysaccharides production and dealing with these agricultural wastes.
EGFR internal tandem duplications in fusion‐negative congenital and neonatal spindle cell tumors
Authors: Koo Selene C. , Schieffer Kathleen M. , Lee Kristy , Gupta Ajay , Pfau Ruthann B. , Avenarius Matthew R. , Stonerock Eileen , LaHaye Stephanie , Fitch James , Setty Bhuvana A. , Roberts Ryan , Ranalli Mark , Conces Miriam R. , Bu Fang , Mardis Elaine R. , Cottrell Catherine E. 
Published: July 2022

AbstractNext‐generation sequencing (NGS) assays can sensitively detect somatic variation, and increasingly can enable the identification of complex structural rearrangements. A subset of infantile spindle cell sarcomas, particularly congenital mesoblastic nephromas with classic or mixed histology, have structural rearrangement in the form of internal tandem duplications (ITD) involving EGFR. We performed prospective analysis to identify EGFR ITD through clinical or research studies, as well as retrospective analysis to quantify the frequency of EGFR ITD in pediatric sarcomas. Within our institution, three tumors with EGFR ITD were prospectively identified, all occurring in patients less than 1 year of age at diagnosis, including two renal tumors and one mediastinal soft tissue tumor. These three cases exhibited both cellular and mixed cellular and classic histology. All patients had no evidence of disease progression off therapy, despite incomplete resection. To extend our analysis and quantify the frequency of EGFR ITD in pediatric sarcomas, we retrospectively analyzed a cohort of tumors (n = 90) that were previously negative for clinical RT‐PCR‐based fusion testing. We identified EGFR ITD in three analyzed cases, all in patients less than 1 year of age (n = 18; 3/18, 17%). Here we expand the spectrum of tumors with EGFR ITD to congenital soft tissue tumors and report an unusual example of an EGFR ITD in a tumor with cellular congenital mesoblastic nephroma histology. We also highlight the importance of appropriate test selection and bioinformatic analysis for identification of this genomic alteration that is unexpectedly common in congenital and infantile spindle cell tumors.
Experimental investigations of pump‐driven closed‐loop thermosyphon system
Authors: Birajdar Mahasidha R. , Sewatkar Chandrasekhar M. 
Published: July 2022

AbstractThe thermal management of the compact electronic system is one of the major challenges in the present power electronics and computational industries. The present paper investigates the effects of a pump‐driven flow on the thermal performance of a closed‐loop thermosyphon (CLT) system. This paper discusses the effect of pump‐driven flow on the thermal performance of CLT. In this study, the experimentation is carried out on the water‐charged pump‐driven closed‐loop thermosyphon (PDLT) with different heat inputs, filling ratios (FR), and adiabatic lengths to understand the effects of these parameters on the thermal performance of the system. The results indicate that the heat transfer performance of CLT is improved using pump‐driven flow in the PDLT and the minimum thermal resistance (0.035 k/W) is obtained at FR = 0.6 and 3 kW heat input. It is also noticed that the thermal resistance of PDLT is up to 35% higher than CLT at FR = 0.6, 0.5 kW heat input, and 500 mm adiabatic length. The unstable geyser boiling phenomenon is eliminated from the system at the adiabatic lengths of 200 and 500 mm. However, for long adiabatic length (800 mm), the geyser boiling occurs at a higher FR (FR = 0.6) and moderate heat flux (0.5 kW).