bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and implementation of the AIDA international registry for patients with Schnitzler's syndrome
Authors: Sota Jurgen , Vitale Antonio , Więsik-Szewczyk Ewa , Frassi Micol , Lopalco Giuseppe , Emmi Giacomo , Govoni Marcello , de Paulis Amato , Marino Achille , Gidaro Antonio , Monti Sara , Opris-Belinski Daniela , Pereira Rosa Maria R. , Jahnz-Rózyk Karina , Gaggiano Carla , Crisafulli Francesca , Iannone Florenzo , Mattioli Irene , Ruffilli Francesca , Mormile Ilaria , Rybak Katarzyna , Caggiano Valeria , Airò Paolo , Tufan Abdurrahman , Gentileschi Stefano , Ragab Gaafar , Almaghlouth Ibrahim A. , Aboul-Fotouh Khalil Adham , Cattalini Marco , La Torre Francesco , Tarsia Maria , Giardini Henrique A. Mayrink , Ali Saad Moustafa , Bocchia Monica , Caroni Federico , Giani Teresa , Cinotti Elisa , Ruscitti Piero , Rubegni Pietro , Dagostin Marília A. , Frediani Bruno , Guler Aslihan Avanoglu , Della Casa Francesca , Maggio Maria Cristina , Recke Andreas , von Bubnoff Dagmar , Krause Karoline , Balistreri Alberto , Fabiani Claudia , Rigante Donato , Cantarini Luca 
Published: July 2022

ObjectiveThe present paper describes the design, development, and implementation of the AutoInflammatory Disease Alliance (AIDA) International Registry specifically dedicated to patients with Schnitzler's syndrome.MethodsThis is a clinical physician-driven, population- and electronic-based registry implemented for the retrospective and prospective collection of real-life data from patients with Schnitzler's syndrome; the registry is based on the Research Electronic Data Capture (REDCap) tool, which is designed to collect standardized information for clinical research, and has been realized to change over time according to future scientific acquisitions and potentially communicate with other existing or future similar registries.ResultsSince its launch, 113 centers from 23 countries in 4 continents have been involved. Fifty-seven have already obtained the approval from their local Ethics Committees. The platform counts 324 users (114 Principal Investigators, 205 Site Investigators, 2 Lead Investigators, and 3 data managers) at current (April 28th, 2022). The registry collects baseline and follow-up data using 3,924 fields organized into 25 instruments, including patient's demographics, history, clinical manifestations and symptoms, trigger/risk factors, laboratory, instrumental exams, therapies, socioeconomic information, and healthcare access.ConclusionsThis International Registry for patients with Schnitzler's syndrome facilitates standardized data collection, enabling international collaborative projects through data sharing and dissemination of knowledge; in turn, it will shed light into many blind spots characterizing this complex autoinflammatory disorder.
Elevated homocysteine levels, white matter abnormalities and cognitive impairment in patients with late-life depression
Authors: Zhou Huarong , Zhong Xiaomei , Chen Ben , Wang Qiang , Zhang Min , Mai Naikeng , Wu Zhangying , Huang Xingxiao , Chen Xinru , Peng Qi , Ning Yuping 
Published: July 2022

BackgroundCognitive impairment in late−life depression (LLD) is considered to be caused by neurodegenerative changes. Elevated homocysteine (Hcy) levels may be linked to cognitive abnormalities associated with LLD. The important role of white matter (WM) damage in cognitive impairment and pathogenesis in patients with LLD has been widely reported. However, no research has explored the interrelationships of these features in patients with LLD.ObjectiveThe goal of the study was to examine the interrelationship between Hcy levels, cognition, and variations in WM microstructure detected by diffusion tensor imaging (DTI) in patients with LLD.MethodsWe recruited 89 healthy controls (HCs) and 113 patients with LLD; then, we measured the plasma Hcy levels of participants in both groups. All individuals performed a battery of neuropsychological tests to measure cognitive ability. Seventy-four patients with LLD and 68 HCs experienced a DTI magnetic resonance imaging (MRI) scan.ResultsPatients with LLD showed significantly lower fractional anisotropy (FA) values in the bilateral inferior longitudinal fasciculus than those of healthy participants. Only in LLD patients was Hcy concentration inversely associated to FA values in the forceps minor. Finally, multiple regression analyses showed that an interaction between Hcy levels and FA values in the right cingulum of the cingulate cortex and right inferior longitudinal fasciculus were independent contributors to the executive function of patients with LLD.ConclusionOur results highlight the complex interplay between elevated homocysteine levels and WM abnormalities in the pathophysiology of LLD-related cognitive impairment, consistent with the neurodegeneration hypothesis.
Proposition of Cutoff Points for Anthropometric Indicators to Identify High Blood Pressure in Adolescents
Authors: Borges Leandro Lima , Gerage Aline Mendes , Monteiro Luciana Zaranza , Ulbrich Anderson Zampier , Silva Diego Augusto Santos 
Published: July 2022

AimTo propose cutoff points for anthropometric indicators for high blood pressure (HBP) screening in adolescents and to identify, among these indicators, those more accurately for boys and girls.MethodsThis cross-sectional study was carried out in the city of São José, SC, Brazil with 634 adolescents aged 14 to 19 years. Blood pressure levels were measured using a digital oscillometric sphygmomanometer and adolescents were classified as having HBP or not. Anthropometric indicators were calculated based on anthropometric measurements such as body mass (BM), height, waist circumference (WC), hip circumference (HC) and triceps, subscapularis, suprailiac, and midcalf skinfold thickness (SF). The Receiver Operating Characteristic Curve (ROC) was used to analyze the predictive capacity of anthropometric indicators in the identification of HBP.ResultsHigher values of Area Under the Curve (AUC) were for the anthropometric indicators BM (0.67; 95%CI: 0.62–0.72), body mass index (BMI) (0.67; 95%CI: 0.62–0.72), and WC (0.67; 95%CI: 0.62–0.71) for males. For females, no anthropometric indicator had discriminatory power for HBP screening. The cutoff points for the anthropometric indicators with discriminatory power for HBP screening in males were BM &gt; 64.80 Kg, BMI &gt; 21.76 Kg/m2, fat percentage (FP) &gt; 15.75, waist height to ratio (WHtR) &gt; 0.41, WC &gt; 73.00 cm, and HC &gt; 92.25 cm.ConclusionAnthropometric indicators of body adiposity had greater discriminatory power of HBP screening in males. For females, caution is suggested because the anthropometric indicators showed AUC values (95%CI) below 0.60.
Postoperative high-density lipoprotein cholesterol level: an independent prognostic factor for gastric cancer
Authors: Li Chenxi , Fu Yan , Li Qiuwen , Yang Xuhui , Wang Wenying , Jin Xin , Bian Lihua , Zhao Hui , Li Donghui , Gao Jie , Du Nan , Peng Liang 
Published: July 2022

ObjectiveThe relationship between serum lipids and prognosis of gastric cancer has not been confirmed. Our purpose in the study was to investigate the associations between preoperative and postoperative serum lipids level and prognosis in patients with gastric cancer.MethodsA retrospective study was performed on 431 patients who received radical (R0) gastrectomy from 2011 to 2013. Preoperative and postoperative serum lipids level were recorded. Clinical-pathological characteristics, oncologic outcomes, disease-free survival (DFS) and overall survival (OS) were collected. The prognostic significance was determined by Kaplan-Meier analysis and Cox proportional hazards regression model.ResultsThere was no significant difference in DFS and OS according to preoperative serum lipids level. Regarding postoperative serum lipids level, compared to normal high-density lipoprotein cholesterol (HDL-C), low postoperative HDL-C level indicated a shorter OS (hazard ratio: 1.76, 99% confidence interval: 1.31–2.38; P=0.000) and a shorter DFS (hazard ratio: 2.06, 99% confidence interval: 1.55–2.73; P=0.000). However, other postoperative serum lipid molecules were not associated with DFS and OS.ConclusionPostoperative HDL-C might be an independent prognostic factor of gastric cancer.
Chemotherapy-induced functional brain abnormality in colorectal cancer patients: a resting‐state functional magnetic resonance imaging study
Authors: Liu Siwen , Guo Yesong , Ni Jie , Yin Na , Li Chenchen , Pan Xuan , Ma Rong , Wu Jianzhong , Li Shengwei , Li Xiaoyou 
Published: July 2022

IntroductionChemotherapy-induced cognitive impairment (i.e., “chemobrain”) is a common neurotoxic side-effect experienced by many cancer survivors who undergone chemotherapy. However, the central mechanism underlying chemotherapy-related cognitive impairment is still unclear. The purpose of this study was to investigate the changes of intrinsic brain activity and their associations with cognitive impairment in colorectal cancer (CRC) patients after chemotherapy.MethodsResting‐state functional magnetic resonance imaging data of 29 CRC patients following chemotherapy and 29 matched healthy controls (HCs) were collected in this study, as well as cognitive test data including Mini Mental State Exam (MMSE), Montreal Cognitive Assessment (MoCA) and Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog). The measure of fractional amplitude of low-frequency fluctuation (fALFF) was calculated and compared between groups. The correlations between the fALFF of impaired brain region and cognitive performance were also analyzed.ResultsCompared with HCs, CRC patients following chemotherapy showed decreased fALFF values in the left anterior cingulate gyrus (ACG) and middle frontal gyrus, as well as increased fALFF values in the left superior frontal gyrus (orbital part) and middle occipital gyrus. Moreover, positive associations were identified between fALFF values of the left ACG and the total scores of MMSE, MoCA and FACT-Cog in the patient group.ConclusionThese findings indicated that CRC patients after chemotherapy had decreased intrinsic brain activity in the left ACG, which might be vulnerable to the neurotoxic side-effect of chemotherapeutic drugs and related to chemotherapy-induced cognitive impairment.
Clinical Manifestations and Complications of Children With COVID-19 Compared to Other Respiratory Viral Infections: A Cohort Inpatient Study From Rio de Janeiro, Brazil
Authors: Pucarelli-Lebreiro Giuliana , Venceslau Marianna Tavares , Cordeiro Catherine Crespo , Maciel Fernanda Queiroz , Anachoreta Thiago Dias , Abreu Thalita Fernandes de , Frota Ana Cristina Cisne , Castiñeiras Terezinha Marta Pereira Pinto , Costa Analucia Mendes da , Lopes Adriana Cristina da Luz , Campos Ludmila Nascimento Rodrigues , Calvano Luiza Maria , Guimaraes Maria Angelica Arpon Marandino , Hofer Cristina Barroso 
Published: July 2022

IntroductionThe coronavirus disease-2019 (COVID-19) clinical manifestations in children and adolescents are diverse, despite the respiratory condition being the main presentation. Factors such as comorbidities and other respiratory infections may play a role in the initial presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aims to describe the epidemiological aspects, clinical, and laboratory manifestations of pediatric patients admitted to a tertiary pediatric hospital in Rio de Janeiro, diagnosed with COVID-19, and compare these with other viral conditions during the first year of the SARS-CoV-2 pandemic.MethodsAll patients under 18 years of age that were admitted with upper airway infection were enrolled and followed up for 30 days. The main dependent variable was the laboratorial diagnosis of SARS-CoV-2, and independent variables were studied through logistic regression.ResultsA total of 533 patients were recruited, and 105 had confirmed SARS-CoV-2 infection. Detection of other viruses occurred in 34% of 264 tested participants. Six patients died (two in SARS-CoV-2 infected group). The variables independently associated with COVID-19 were older age (OR = 1.1, 95% CI = 1.0–1.1), lower leukocytes count at entry (OR = 0.9, 95% CI = 0.8–0.9), and contact with suspected case (OR = 1.6, 95% CI = 1.0–2.6). Patients with COVID-19 presented higher odds to be admitted in an intensive care unit (OR = 1.99, 95% CI = 1.08–3.66).ConclusionsEven during the SARS-CoV-2 pandemic, several other respiratory viruses were present in admitted pediatric patients. Variables associated with COVID-19 infection were older age, lower leukocytes count at entry, and a domiciliary suspect contact. Although patients with COVID-19 were more frequently admitted to ICU, we did not observe higher mortality in this group.
Case report: Localized xanthogranulomatous pyelonephritis in children: A case report and literature review
Authors: Deng Qi-Fei , Chu Han , Peng Bo , Liu Xiang , Cao Yong-Sheng 
Published: July 2022

BackgroundXanthogranulomatous pyelonephritis (XGPN), which is featured by inflammatory destruction of renal parenchyma and fibrosis of kidney, occurs mainly among adults, sporadically among children and rarely among infants. Recurrent urinary tract infections, kidney stone-induced obstructive nephropathy, malnutrition, abnormal lipid metabolism, hypoimmunity, lymphatic obstruction and congenital urinary abnormalities may all cause XGPN among children. Its primary treatment is radical nephrectomy.Case descriptionIn this study, we describe a rare case of XGPN in a 7-year-old boy infected with Staphylococcus aureus (S. aureus). The child presented with symptoms including recurrent fever, urine culture negative. The postoperative pathology confirmed XGPN. Besides, partial nephrectomy was performed.ConclusionXGPN, as a special type of chronic pyelonephritis, is a rare pyelonephritis requiring surgical treatment. Early diagnosis and treatment are crucial to reducing its morbidity and mortality. Although radical nephrectomy is the primary therapeutic option for patients with XGPN, partial nephrectomy surgery should be considered for focal XGPN, aiming to preserve residual renal function in children as far as possible.
Resting Physiologic Dead Space as Predictor of Postoperative Pulmonary Complications After Robotic-Assisted Lung Resection: A Pilot Study
Authors: Godbole Rohit , Church Sanford B. , Abolhoda Amir , Porszasz Janos , Sassoon Catherine S. H. 
Published: July 2022

Lung resection surgery carries significant risks of postoperative pulmonary complications (PPC). Cardiopulmonary exercise testing (CPET) is performed to predict risk of PPC in patients with severely reduced predicted postoperative forced expiratory volume in one second (FEV1) and diffusion of carbon monoxide (DLCO). Recently, resting end-tidal partial pressure of carbon dioxide (PETCO2) has been shown as a good predictor for increased risk of PPC. However, breath-breath breathing pattern significantly affects PETCO2. Resting physiologic dead space (VD), and physiologic dead space to tidal volume ratio (VD/VT), may be a better predictor of PPC than PETCO2. The objective of this study was to prospectively determine the utility of resting measurements of VD and VD/VT in predicting PPC in patients who underwent robotic-assisted lung resection for suspected or biopsy-proven lung malignancy. Thirty-five consecutive patients were included in the study. Patients underwent preoperative pulmonary function testing, symptom-limited CPET, and a 6-min walk test. In the first 2 min prior to the exercise portion of the CPET, we obtained resting VT, minute ventilation (V˙E), VD (less instrument dead space), VD/VT, PETCO2, and arterial blood gases. PPC within 90 days were recorded. Fourteen (40%) patients had one or more PPC. Patients with PPC had significantly elevated resting VD compared to those without (0.318 ± 0.028 L vs. 0.230 ± 0.017 L (± SE), p &lt; 0.006), and a trend toward increased VD/VT (0.35 ± 0.02 vs. 0.31 ± 0.02, p = 0.051). Area under the receiver operating characteristic (ROC) for VD was 0.81 (p &lt; 0.002), VD/VT was 0.68 (p = 0.077), and PETCO2 was 0.52 (p = 0.840). Peak V˙O2, V˙E/ V˙CO2 slope, pulmonary function tests, 6-min walk distance and arterial blood gases were similar between the two groups. Intensive care unit and total hospital length of stay was significantly longer in those with PPC. In conclusion, preoperative resting VD was significantly elevated in patients with PPC. The observed increase in resting VD may be a potentially useful predictor of PPC in patients undergoing robotic-assisted lung resection surgery for suspected or biopsy-proven lung malignancy. A large prospective study is needed for confirmation.
The Different Classification of Hospitals Impact on Medical Outcomes of Patients in China
Authors: Li Lele , Du Tiantian , Zeng Siyu 
Published: July 2022

BackgroundIn China, different classification of hospitals (COH) provide treatment for patients with different degrees of illness. COH play an important role in Chinese medical outcomes, but there is a lack of quantitative description of how much impact the results have. The objective of this study is to examine the correlation between COH on medical outcomes with the hope of providing insights into appropriate care and resource allocation.MethodsFrom the perspective of the COH framework, using the Urban Employee Basic Medical Insurance (UEBMI) data of Chengdu City from 2011 to 2015, with a sample size of 512,658 hospitalized patients, this study used the nested multinomial logit model (NMNL) to estimate the impact of COH on the medical outcomes.ResultsThe patients were mainly elderly, with an average age of 66.28 years old. The average length of stay was 9.61 days. The female and male gender were split evenly. A high level of hospitals is positively and significantly associated with the death and transfer rates (p &lt; 0.001), which may be related to more severe illness among patients in high COH.ConclusionThe COH made a difference in the medical outcomes significantly. COH should be reasonably selected according to disease types to achieve the optimal medical outcome. So, China should promote the construction of a tiered delivery system.
Construction and Application of Standardized Postoperative Pain-Management Procedure for Patients With Perianal Abscess: A Retrospective Study
Authors: Wang Xiu-Mei , Jiang Wei-Lian , Ma Li-Fang , Guo Yue , Cui Li-Ping , Niu Yan-Bin 
Published: July 2022

ObjectiveThe present study explored the construction and application of a standardized postoperative pain-management procedure for patients with perianal abscess.MethodsTwo study groups (the observation group and the intervention group) were established retrospectively. The observation group comprised 46 patients with perianal abscess who enrolled in this study between June 2019 and June 2020. The intervention group comprised 48 patients who enrolled in the study between July 2020 and July 2021. All patients were enrolled using the convenience sampling method. A pain-management team was established, and standardized procedure management was implemented in the intervention group, while routine pain management was implemented in the observation group. Indices related to the patients' postoperative pain-control satisfaction and rehabilitation were compared between the two groups.ResultsThe patients' pain-control satisfaction, wound edema score, edema disappearance time, urinary retention, and defecation difficulty following intervention were better in the intervention group than in the observation group, and the differences were statistically significant (P &lt; 0.05 for all).ConclusionThe implementation of the standardized postoperative pain-management procedure in patients with perianal abscess can effectively improve the patient's level of pain and satisfaction and promote rehabilitation.
About the Grinding of Gear Hob’s Rake Face
Authors: Hodgyai Norbert , Drăgoi Mircea Viorel , Tolvaly-Roşca Ferenc , Máté Márton 
Published: July 2022

Abstract
The most simple and robust construction of the monolithic gear hobs present a common helical rake face for a given line of teeth, whose generatrix is a straight-line segment perpendicular to the hob’s axis while its directory is a helix, perpendicular to the pitch helix. As a consequence, constructive rake angles are zero on all edges. Total curvatures of such a surface are negative. Thus, it can be grinded only using the conical surface of a platter type grinding wheel, or a grinding bit. Despite this, some industry practices, possibly for reasons of simplicity and cost lowering, involve the plain grinding surface, supposed to a helical motion. This paper deals with the CAD-simulation of the grinding process using the plain wheel surface, and it shows the differences between the theoretical and rake face and the real obtained helical surface.
More Constructions of Light MDS Transforms Based on Known MDS Circulant Matrices
Authors: Wang Jin-Bo , Wu You , Zhou Yu 
Published: July 2022

Maximum distance separable (MDS) codes have the maximum branch number in cryptography, and they are generally used in diffusion layers of symmetric ciphers. The diffusion layer of the Advanced Encryption Standard (AES) uses the circulant MDS matrix with the row element of {2;3;1;1} in F28. It is the simplest MDS matrix in F2n4, recorded as A=Circ(2;3;1;1). In this paper, we study the more extensive MDS constructions of A in F2n4. By transforming the element multiplication operation in the finite field into the bit-level operation, we propose a multivariable operation definition based on simple operations, such as cyclic shift, shift, and XOR. We apply this multivariable operation to more lightweight MDS constructions of A and discuss the classification of the MDS clusters. We also give an example of the MDS cluster of A. Without changing the structure, elements, and the implementation cost of the known MDS matrix, the number of existing MDS transformations is expanded to n2/2 times that of its original. The constructions in this paper provide rich component materials for the design of lightweight cryptographic algorithms.
Effect of Cold Rolling Prior to Annealing on the Grain Size-Energy Losses Relationship in a Low Carbon Grain Non-Oriented Semi-Processed Electrical Steel
Authors: López-Granados Nancy Margarita , Gutiérrez-Castañeda Emmanuel José , Salinas-Rodríguez Armando 
Published: July 2022

In this work, the effect of cold deformation prior to annealing treatment on the microstructure and magnetic hysteresis energy losses in a low carbon grain non-oriented semi-processed electrical steel with 0.60 mm thickness was investigated. The samples were subjected to different percentages of deformation, in a range of 5–20% reduction and annealed at temperatures between 650 and 950 °C for 60 min, these were characterized by Optical Microscopy. Meanwhile the energy losses were calculated from the magnetic hysteresis loops using a Vibrating Sample Magnetometer. The experimental results showed that cold deformation increases energy losses by 50% when the steel is deformed 20%, due to microstructural defects that are introduced to the material during deformation. The presence of the microstructural defects was verified through measurements of Full Width at Half Maximum by means of X-ray diffraction. On the other hand, it was observed that annealing at temperatures below Ac1 causes only small changes in the microstructure of the steel, however, it promotes the recovery of magnetic properties by 50% with respect to the deformed material. In contrast, when the material is annealed between Ac1 and Ac3 (α+γ) magnetic properties are recovered ~33% with respect to the initial state and, at values higher than 65% compared to the state of greatest deformation (20%), as a result of both microstructural modification and the evolution of the grain size experienced by the material.