bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation Analysis of Response of Sorbus pohuashanensis Leaves to High-temperature Stress Based on Label Free-based Quantitative Proteomic and Transcriptomic
Authors: Pei Xin , Zhu Lingyi , Guan Xuelian , Zhang Ruili , Zhang Yan , Lu Yizeng , Dou Dequan , Zheng Jian 
Published: March 2022

Abstract
Background: High-temperature stress is the main abiotic stress of Sorbus pohuashanensis (Hance) Hedl. introduced from the mountains to plain areas. To investigate the mechanisms of heat response in S. pohuashanensis, we compared the transcriptome and proteome after high temperature stress at 43 °C for 8 h. Results: Proteomic sequencing yielded 92 (51 upregulated and 41 downregulated) DAPs, involving heat-killed proteins, molecular chaperones, energy metabolism, signal transduction, cellular autophagy, and reactive oxygen species scavenging systems. TEM results indicated that high-temperature stress led to disruption of the structural integrity of chloroplasts in mature chloroplast cells, reduction of chloroplast vesicle-like lamellae, accumulation of lipophilic granules, and an increase in the number of vesicles. Quantitative combined transcriptomic and proteomic analyses yielded 34 pairs of DAPs/DEG-associated genes. The functional enrichment of these DAPs/DEGs indicated that their functions were related to chaperones, energy metabolism, ROS scavenging system, and cell wall modification. Conclusion: 92 DAPs were identified in the proteomic analysis of S. pohuashanensis under high temperature stress, and co-regulatory analysis revealed 34 DAPs/DEGs in the comparison group, with 24 genes having the same protein and mRNA expression trends and 10 genes with opposite protein and mRNA expression trends. These genes are collectively involved in response to high temperature stress by encoding proteins related to molecular chaperones, energy metabolism, ROS scavenging systems and cell wall modifications. These results provide a basis for the complex HSF–Hsp regulatory network contributes to the heat tolerance of S. pohuashanensis.
Solid solution of CaSiO3 and MgSiO3 perovskites in the lower mantle: The role of ferrous iron
Authors: Zhang Feiwu , Xiao Tingting , Muir Joshua M.R. 
Published: March 2022

AbstractThe solid solution between CaSiO3 and MgSiO3 perovskites is an important control on the properties of the lower mantle but the effect of one of the most important impurity elements (iron) on this solution is largely unknown. Using density functional theory (DFT), ferrous iron’s influence on the reciprocal solubility of MgSiO3 and CaSiO3 perovskite (forming a single Ca-Mg mixed perovskite phase) was calculated under pressures and temperatures of 25–125 GPa and 0–3000 K, respectively. Except at iron-rich conditions, ferrous iron preferentially partitions into the mixed perovskite phase over bridgmanite. This is a small effect (partitioning coefficient KD ~0.25–1), however, when compared to the partitioning of ferrous iron to ferropericlase, which rules out perovskite phase mixing as a mechanism for creating iron-rich regions in the mantle. Iron increases the miscibility of Ca and Mg perovskite phases and reduces the temperature at which the two perovskite phases mix but this effect is highly nonlinear. We find that for a pyrolytic mantle [Ca% = 12.5 where Ca% = Ca/(Ca+Mg)] a perovskite ferrous iron concentration of ~13% leads to the lowest mixing temperature and the highest miscibility. With this composition, 1% ferrous iron in a pyrolytic composition would lead to mixing at ~120 GPa along the geothermal gradient, and 6.25% ferrous iron leads to mixing at ~115 GPa and 13% ~110 GPa. At high iron concentrations, Fe starts to impair miscibility, with 25% ferrous iron leading to mixing at ~120 GPa. Thus, in normal pyrolytic mantle, iron could induce a small amount of Ca-pv and Mg-pv mixing near the D″ layer but it generally partitions to ferropericlase instead and does not impact mixing. Extremely iron rich parts of the lower mantle such as ULVZs or the CMB (potentially) are also not a likely source of phase mixed perovskites due to the nonlinear effect of ferrous iron on phase mixing.
Palliative Care and Pulmonary Arterial Hypertension
Authors: Rhee Laura S. , Morgan Alisha A. , DuBrock Hilary M. 
Published: March 2022

Background
Pulmonary arterial hypertension (PAH) is a chronic and progressive disease associated with impaired health-related quality of life and survival. Palliative care (PC) is patient- and family-centered care provided by an interdisciplinary team with an overarching goal of alleviating suffering and improving quality of life for patients with advanced illness. PC in other chronic diseases is associated with improved quality of life, symptom management, illness understanding, and reduced caregiver burden, but there is limited data regarding PC in PAH. Despite limited evidence, there is strong rationale for involving PC specialists in the longitudinal management of PAH.

Implications for Clinicians
There are currently no guidelines to help clinicians determine the most appropriate timing for referral of PAH patients to PC specialty teams. Consequently, referrals are limited and often delayed. Adoption of a standardized approach to PC referrals based on clinical or patient triggers could facilitate earlier involvement of PC as an adjunct to ongoing PAH disease-directed care.

Conclusions
Incorporation of PC in the longitudinal management of PAH may be beneficial to address the multidimensional aspects of living with a chronic and life-limiting illness.
Selected Phytochemicals to Combat Lungs Injury: Natural Care
Authors: Samadder Asmita , Nandi Sisir , Dey Rishita 
Published: March 2022

Abstract:
The human has two lungs responsible for respiration and drug metabolism. Severe lung
infection caused by bacteria, mycobacteria, viruses, fungi, and parasites may lead to lungs injury.
Smoking and tobacco consumption may also produce lungs injury. Inflammatory and pain mediators
are secreted by alveolar macrophages. The inflammatory mediators, such as cytokines, interleukin
(IL)-1, IL-6, IL-8, IL-10, and tumor necrosis factor (TNF)-α, neutrophils, and fibroblasts are
accumulated in the alveoli sac, which becomes infected. It may lead to hypoxia followed by severe
pulmonary congestion and the death of the patient. There is an urgent need for the treatment of artificial
respiration and ventilation. However, the situation may be the worst for patients suffering
from lung cancer, pulmonary tuberculosis, and acute pneumonia caused by acute respiratory distress
syndrome (ARDS). Re-urgency has been happening in the case of coronavirus disease of
2019 (COVID-19) patients. Therefore, it is needed to protect the lungs with the intake of natural
phytomedicines. In the present review, several selected phyto components having the potential role
in lung injury therapy have been discussed. Regular intake of natural vegetables and fruits bearing
these constituents may save the lungs even in the dangerous attack of SARS-CoV-2 in lung cancer,
pulmonary TB, and pneumatic patients.
Advances in the Pharmacological and Non-pharmacological Management
of Non-motor Symptoms in Parkinson’s Disease: An Update Since 2017
Authors: Wamelen Daniel J. Van , Rukavina Katarina , Podlewska Aleksandra M. , Chaudhuri K. Ray 
Published: March 2022

Background:
Non-motor symptoms (NMS) are an important and ubiquitous determinant
of quality of life in Parkinson’s disease (PD). However, robust evidence for their treatment is still a
major unmet need.

Objective:
This study aimed to provide an updated review on advances in pharmacological, nonpharmacological,
and exercise-based interventions for NMS in PD, covering the period since the
publication of the MDS Task Force Recommendations.

Methods:
We performed a literature search to identify pharmacological, non-pharmacological, and
exercise-based interventions for NMS in PD. As there are recent reviews on the subject, we have
only included studies from the 1st of January 2017 to the 1st of December 2021 and limited our
search to randomised and non-randomised (including open-label) clinical trials.

Results:
We discuss new strategies to manage NMS based on data that have become available since
2017, for instance, on the treatment of orthostatic hypotension with droxidopa, several dopaminergic
treatment options for insomnia, and a range of non-pharmacological and exercise-based interventions
for cognitive and neuropsychiatric symptoms, pain, and insomnia and excessive sleepiness.

Conclusion:
Recent evidence suggests that targeted non-pharmacological treatments, as well as
some other NMS management options, may have a significant beneficial effect on the quality of life
and need to be considered in the pathways of treatment of PD.
Clinical and Molecular Heterogeneity of Silver-Russell Syndrome and
Therapeutic Challenges: A Systematic Review
Authors: Khetarpal Preeti , Singh Amit , Pajni Ketan , Panigrahi Inusha 
Published: March 2022

Background:
Silver-Russell syndrome (SRS) is a developmental disorder involving ex-treme growth failure, characteristic facial features and underlying genetic heterogeneity. As the clinical heterogeneity of SRS makes diagnosis a challenging task, the worldwide incidence of SRS could vary from 1:30,000 to 1:100,000. Although various chromosomal, genetic, and epigenetic mutations have been linked with SRS, the cause had only been identified in half of the cases.

Material and Methods:
To have a better understanding of the SRS clinical presentation and muta-tion/epimutation responsible for SRS, a systematic review of the literature was carried out using ap-propriate keywords in various scientific databases (PROSPERO protocol registration CRD42021273211). Clinical features of SRS have been compiled and presented corresponding to the specific genetic subtype. An attempt has been made to understand the recurrence risk and the role of model organisms in understanding the molecular mechanisms of SRS pathology, treatment, and management strategies of the affected patients through the analysis of selected literature.

Results:
156 articles were selected to understand the clinical and molecular heterogeneity of SRS. Information about detailed clinical features was available for 228 patients only, and it was observed that body asymmetry and relative macrocephaly were most prevalent in cases with methylation defects of the 11p15 region. In about 38% of cases, methylation defects in ICRs or genomic muta-tions at the 11p15 region have been implicated. Maternal uniparental disomy of chromosome 7 (mUPD7) accounts for about 7% of SRS cases, and rarely, uniparental disomy of other autosomes (11, 14, 16, and 20 chromosomes) has been documented. Mutation in half of the cases is yet to be identified. Studies involving mice as experimental animals have been helpful in understanding the underlying molecular mechanism. As the clinical presentation of the syndrome varies a lot, treat-ment needs to be individualized with multidisciplinary effort.

Conclusion:
SRS is a clinically and genetically heterogeneous disorder, with most of the cases be-ing implicated with a mutation in the 11p15 region and maternal disomy of chromosome 7. Recur-rence risk varies according to the molecular subtype. Studies with mice as a model organism have been useful in understanding the underlying molecular mechanism leading to the characteristic clin-ical presentation of the syndrome. Management strategies often need to be individualized due to varied clinical presentations.
Diabetic Ketoacidosis (DKA), a Leading Risk Factor for Mucormycosis
(Black Fungus), during the Era of Coronavirus Disease-2019 (COVID-19):
An Overview
Authors: Rais Nadeem , Ahmad Rizwan , Ved Akash , Parveen Kehkashan , Bari Darakhshan Gazala , Prakash Om 
Published: March 2022

Introduction:
Diabetes mellitus (DM) and steroid medication, coincided with coronavirus
disease 2019 (COVID-19), results in a weakened immune system, allowing some commonly
found pathogens to become more harmful. Mucormycosis (black fungus) is a type of opportunistic
infection caused by fungi belonging to the Mucorales family. DM is the most prominent risk factor
for mucormycosis. Excessive blood sugar and decreased insulin levels lead to diabetic ketoacidosis
(DKA), a devastating complication of DM that can be fatal if left untreated.

Methods:
Diabetic ketoacidosis is more common in type 1 diabetic patients, although it can also be
fall in type 2 diabetic patients. DKA occurs when the body lacks enough insulin to allow blood
sugar to enter the cells and is used for energy. Instead, the liver breaks down fat for fuel-producing
chemicals known as ketones.

Results:
When too many ketones are created too quickly, they can reach dangerously high levels in
the body. Mucormycosis is a rare but serious infectious disease that requires medication or surgical
removal.

Conclusion:
The confluence of diabetes and COVID-19 makes managing mucormycosis a serious
and dead issue. Although the effectiveness of prophylactic antifungal therapy has yet to be demonstrated,
hyperglycemia control appears to be the most important step in managing mucormycosis in
DKA patients.
ZY12201: A Potent TGR5 Agonist: Identification of a Novel Pan CYP450
Inhibitor Tool Compound for In-Vitro Assessment
Authors: Giri Poonam , Gupta Lakshmikant , Rathod Anil , Joshi Vipul , Giri Shyamkumar , Patel Nirmal , Agarwal Sameer , R Jain Mukul 
Published: March 2022

Background:
The key objective was to evaluate the CYP inhibition potential of ZY12201 for an opportunity
to use it as a tool compound for pan CYP inhibition activities.

Objective:
The key objective was to evaluate the CYP inhibition potential of ZY12201 for an opportunity
to use it as a tool compound for pan CYP inhibition activities.

Method:
In-vitro Drug-Metabolizing Enzyme (DME) inhibition potential of ZY12201 was evaluated
against major CYP isoforms (1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A4/5), Aldehyde
Oxidase (AO), Monoamine Oxidase (MAO), and Flavin-containing Monooxygenase (FMO) in
human liver cytosol/mitochondrial preparation/microsomes using probe substrates and Liquid
Chromatography with tandem Mass Spectrometry (LC-MS-MS) method).

Results:
It was found that the study conducted on ZY12201 at 100 μM ZY12201 showed a reduction
in the metabolism of vanillin (AO probe substrate), tryptamine (MAO probe substrate), and
benzydamine (FMO probe substrate) by 49.2%, 14.7%, and 34.9%, respectively. ZY12201 Ki values
were 0.38, 0.25, 0.07, 0.01, 0.06, 0.02, 7.13, 0.03 and 0.003 μM for CYP1A2, CYP2B6,
CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4/5 (substrate: testosterone) and
CYP3A4/5 (substrate: midazolam), respectively. Time-dependant CYP inhibition potential of
ZY12201 was assessed against CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6,
CYP2E1, and CYP3A4/5, and no apparent IC50 shift was observed.

Conclusions:
ZY12201, at 100 μM concentration, showed low inhibition potential of AO, MAO,
and FMO. ZY12201 was found as a potent inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, and
3A4/5 while moderately inhibiting CYP2E1. Inhibition of CYP1A2, CYP2B6, CYP2C19, and
CYP2E1 by ZY12201 was competitive, while the inhibition of CYP2C8, CYP2C9, CYP2D6, and
CYP3A4/5 was of mixed-mode. ZY12201 is a non-time-dependent inhibitor of CYP1A2,
CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5.
In summary, the reported Ki values unequivocally support that ZY12201 has a high potential to
inhibit all major CYP isoforms. ZY12201 can be effectively used as a tool compound for in-vitro
evaluation of CYP-based metabolic contribution to total drug clearance in the lead optimization
stage of drug discovery research.
Prevalence of Anemia among Chronic Myeloid Leukemia Patients Treated
with Imatinib: A Evidence-based Meta-analysis
Authors: Sharma Manju , Singh Avinash Kumar , Kumar Anoop , Agrawal Narendra , Bhurani Dinesh , Ahmed Rayaz 
Published: March 2022

Backgrounds:
Imatinib is one of the tyrosine kinase inhibitors used for the treatment of
chronic myeloid leukemia (CML) patients. The exact association of imatinib with anemia in CML patients
is still unclear.

Aim:
The current study aimed to find the prevalence of anemia in chronic myeloid leukemia patients
treated with imatinib.

Methods:
The relevant articles were searched in PubMed, Google scholar, and Clinical trials registries
till 31st July, 2021. The quality of the articles was assessed using the Newcastle-Ottawa Scale. The
prevalence rate with 95% CI was calculated using StatsDirect Statistical analysis software V.3.

Results:
A total of 18 studies containing 3537 patients were found relevant for the analysis. The
pooled prevalence of anemia in CML was found to be 34% (95% CI: 23%-46%). However, the heterogeneity
among studies was found to be high.

Conclusion:
The monitoring of hemoglobin levels and identifying the cause of anemia are major concerns
for the CML patients treated with Imatinib.
ACCOUNTING PERSPECTIVE ON THE ISLAMIC-DRIVEN ACCOUNTABILITY IN A TRADITIONAL ISLAMIC ORGANISATION IN JAVA
Authors: Prasetio Januar Eko , Triyuwono Iwan , Sukoharsono Eko Ganis , Purwanti Lilik 
Published: March 2022

Purpose â€”Â This study explores an accounting perspective on the Islamic-driven accountability in Gus Miekâ€™s Jantiko Mantab community, a traditional Islamic organization in Java. The Jantiko Mantab is an East Java-based community initiated by KH. Hamim Tohari Jazuli (Gus Miek) in 1970s. Regardless of the unique and controversial method of Gus Miek, this community was selected as the object due to its progressive development in the Islamic movement on the number of followers especially in grass root and marginalized communities in Java. The study focuses on two main public activities of the Jantiko Mantab, which are continuously held from one place to other places, namely Al Quran recitation (Semaan) and praising Allah using holy sentences (Dzikrul Ghofilin) in the congregation.Design/methodology/approach â€”Â This study is qualitative research with a spiritual paradigm approach and uses a spiritual perspective analysis method through tawasul, zikir, and syir (pray). The study is conducted through bibliography reviews, interviews, and direct observations.Findings â€”Â The results of this study showed Religious activities within the community were experienced to gain a comprehensive understanding of the founder, leader, and member perspectives on the organizationâ€™s accountability. Accountability in Jantiko Mantab was understood as a formal aspect of accounting, such as financial reports, and also performed and nurtured in accordance to the human task as Khalifatullah fil Ardh. The concept of Khalifatullah fil ArdhÂ is embedded in their community and considered as the accountability uniqueness of Jantiko Mantab.Practical implications â€” Semaan Al-Qurâ€™an and Dzikrul Ghofilin of Jantiko Mantab should make a change in interpreting the concept of accountability that is currently loaded with capitalist interests by incorporating Islamic values sourced from Al Qur'an and hadiths.Originality/value â€” This Islamic value, which is also delivered and reflected by their leaders, is likely to drive the member perception of the organization's accountability.Â Keywords â€”Â Accountability, Islamic value, Islamic organization, Indonesia.Â Paper type â€” Case Study
Pendampingan KSM Bidang Sains Terintegrasi Agama Melalui Pendekatan Hybrid Di Masa Pandemi Covid-19
Authors: Yuliana Ika Farida , Fatayah Fatayah , Priyasmika Rendy , Purwanto Kriesna Kharisma , Rohmah Rosyidah Syafaatur , Maulidah Tsalitsatul 
Published: March 2022

Pandemi virus Corona yang melanda Indonesia sejak tahun 2020 memberikan dampak nyata khususnya pada bidang Pendidikan. Kondisi ini mengakibatkan adanya pembatasan kegiatan bimbingan tatap muka dalam pendampingan KSM. Tujuan kegiatan pengabdian ini adalah untuk memberikan ketrampilan kepada siswa tentang penalaran jawaban dari soal dan pemahaman materi sains yang menyeluruh dikaitkan dengan agama serta nilai keislaman. Metode yang dilakukan dalam kegiatan ini adalah melalui pendampingan menggunakan pendekatan pembelajaran hybrid, yaitu pendampingan melalui tatap muka langsung dan secara daring menggunakan Grup Whatsapp. Kegiatan pendampingan ini dilakukan pada kelas V dan VI di MI Al-Khoiriyah 1 Delegan. Jumlah siswa sasaran adalah 4 orang siswa yang terpilih dan terbagi dalam kelompok IPA dan Matematika untuk mewakili dalam kegiatan KSM. Hasil dari pendampingan menunjukkan peningkatan penguasaan konsep materi dan ketrampilan menjawab siswa yang ditunjukkan dengan nilai rata-rata 82. Selain itu siswa juga dapat lebih memahami konsep sains yang diberikan dan integrasinya dengan agama. Kata kunci: pendampingan; KSM; pendekatan hybrid; covid-19.
PENGEMBANGAN MODUL SISTEM PENDINGIN UNTUK KELAS XI DI UPT SMK NEGERI 8 PALEMBANG
Authors: Wijaya Herli Padli 
Published: March 2022

Penelitian ini bertujuan untuk: 1) mengembangkan produk modul sistem pendingin, 2) mengetahui kelayakan modul sistem pendingin menurut ahli media, 3) mengetahui kelayakan modul sistem pendingin menurut para ahli materi, 4) mengetahui tanggapan guru dan peserta didik pada modul sistem pendingin. Penelitian ini merupakan penelitian Research and Development dengan metode pengembangan ADDIE menurut Branch. Penelitian ini menggunakan teknik pengumpulan data dengan metode observasi, wawancara dan angket. Hasil penelitian dan pengembangan ini adalah: 1) menghasilkan produk akhir berupa modul perawatan sistem pendingin dengan spesifikasi yaitu : memiliki judul “Modul Perawatan Sistem Pendingin”, bahan ajar cetak dengan ukuran kertas A4 dan modul menggunakan kompetensi dasar (KD) 3 sistem pendingin. 2) kelayakan modul mendapatkan skor 3,95 dari penilaian ahli materi termasuk kategori “sangat layak”, mendapatkan skor 3,36 dari penilaian ahli media termasuk kategori “sangat layak”, mendapatkan skor 3,72 dan 3,76 dari penilaian guru pada aspek materi dan aspek media termasuk kategori “sangat mudah dipahami” dan “sangat menarik”, mendapatkan skor 3,46 dari penilaian peserta didik sebagai pengguna termasuk kategori “sangat bermanfaat”.