bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute myocardial infarction at a district hospital in KwaZulu-Natal – Management and outcomes
Authors: Badat Zakariya , Rangiah Selvandran 
Published: June 2022

Background: Acute myocardial infarction (AMI) following ischaemic heart disease (IHD) is associated with increased morbidity and mortality. The condition remains a management challenge in resource-constrained environments. This study analysed the management and outcomes of patients presenting with AMI at a district hospital in KwaZulu-Natal.Methods: A descriptive study that assessed hospital records of all patients diagnosed with AMI over a 2-year period (01 August 2016 to 31 July 2018). Data extracted recorded patient demographics, risk factors, timing of care, therapeutic interventions, follow up with cardiology and mortality of patients.Results: Of the 140 patients who were admitted with AMI, 96 hospital records were analysed. The mean (standard deviation [s.d.]) age of patients was 55.8 (±12.7) years. Smoking (73.5%) and hypertension (63.3%) were the most prevalent risk factors for patients with ST elevation myocardial infarction (STEMI) in contrast to dyslipidaemia (70.2%) and hypertension (68.1%) in patients with non-ST elevation myocardial infarction (NSTEMI). Almost 49.5% of patients arrived at hospital more than 6 h after symptom onset. Three (12.5%) patients received thrombolytic therapy within the recommended 30-min time frame. The mean triage-to-needle time was 183 min – range (3; 550). Median time to cardiology appointment was 93 days. The in-hospital mortality of 12 deaths considering 140 admissions was 8.6%.Conclusion: In a resource-constrained environment with multiple systemic challenges, in-hospital mortality is comparable to that in private sector conditions in South Africa. This entrenches the role of the family physician. There is need for more coordinated systems of care for AMI between district hospitals and tertiary referral centres.
Factors associated with viral suppression among adolescents on antiretroviral therapy in Free State province, South Africa
Authors: Elashi Balsam A.Y. , Van Wyk Brian E. 
Published: June 2022

Background: In 2019, about 1.7 million adolescents between the ages of 10 and 19 years were living with HIV worldwide, of which 170 000 were newly infected with HIV in 2019. South Africa has the highest number of persons living with HIV. Although there has been major improvement in access to antiretroviral therapy (ART), it is still unclear what proportion of adolescents (aged 10–19 years) are virally suppressed in the provinces of South Africa.Objectives: To determine the prevalence of and the factors associated with viral suppression among adolescents (10–19 years) on ART in the Thabo Mofutsanyane District Municipality of the Free State province of South Africa.Method: A retrospective cross-sectional analysis of demographic, clinical and treatment-related information that were extracted from an electronic database was conducted using Statistical Package for the Social Sciences version 26.Results: The median duration on ART was 6.58 years. Although 78% (n = 4520) of adolescents living with HIV who were on ART achieved viral suppression ( 1000 copies/mL), only 9.5% (n = 430) were fully suppressed at 50 copies/mL. In multivariate analysis, the odds of being virally suppressed reduced with increasing age at ART initiation. Adolescents with CD4 counts greater than 500 cells/mm3 at baseline had a higher odds ratio of viral suppression (adjusted odds ratio [AOR]: 1.77; confidence interval [CI]: 1.28–2.47). The odds of viral suppression were significantly lower among those not retained in care (AOR: 0.45; CI: 0.35–0.58).Conclusion: Tailored interventions should be developed to improve viral suppression among adolescents on ART.
Expanding on the use of The International Classification of Functioning, Disability and Health: Examples and resources
Authors: Maart Soraya , Sykes Catherine 
Published: June 2022

Most physiotherapists today are familiar with the abbreviation ICF and know that it stands for the International Classification of Functioning, Disability and Health; the title of the World Health Organization’s international standard for describing health and health related states. Most universities in South Africa and globally have adopted the framework of the ICF in their curricula especially in promoting clinical reasoning, however, translating that knowledge for recording and monitoring has been slow in coming. Less well known, is how the ICF is and can be used and how it can inform physiotherapy practice, research, education and administration. Our article outlines the importance of the ICF to physiotherapy and recommends resources to facilitate expanded ICF use by physiotherapists. Examples are given of how to use coding and the importance of aggregating data and concluding with resources that can assist with the expanded use. Sufficient evidence and resources are available to support the expanded use of the ICF for data collection and clinical coding.Clinical implications: The aggregation of data can be used for the monitoring of universal health coverage especially in the context of National Health Insurance implementation.
Genetic Spectrum of Inherited Neuropathies in India
Authors: Sharma Shivani , Govindaraj Periyasamy , Chickabasaviah Yasha T. , Siram Ramesh , Shroti Akhilesh , Seshagiri Doniparthi V. , Debnath Monojit , Bindu Parayil S. , Taly Arun B. , Nagappa Madhu 
Published: June 2022

Background and Objectives:
Charcot-Marie-Tooth (CMT) disease is the commonest inherited neuromuscular disorder and has heterogeneous manifestations. Data regarding genetic basis of CMT from India is limited. This study aims to report the variations by using high throughput sequencing in Indian CMT cohort.

Methods:
Fifty-five probands (M:F 29:26) with suspected inherited neuropathy underwent genetic testing (whole exome: 31, clinical exome: 17 and targeted panel: 7). Their clinical and genetic data were analysed.

Results:
Age at onset ranged from infancy to 54 years. Clinical features included early-onset neuropathy (n=23), skeletal deformities (n=45), impaired vision (n=8), impaired hearing (n=6), facial palsy (n=8), thickened nerves (n=4), impaired cognition (n=5), seizures (n=5), pyramidal signs (n=7), ataxia (n=8) and vocal cord palsy, slow tongue movements and psychosis in one patient each. Twenty-eight patients had demyelinating electrophysiology. Abnormal visual and auditory evoked potentials were noted in 60.60% and 37.5% respectively. Sixty two variants were identified in 37 genes including variants of uncertain significance (n=34) and novel variants (n=45). Eleven patients had additional variations in genes implicated in CMTs/ other neurological disorders. Ten patients did not have variations in neuropathy associated genes, but had variations in genes implicated in other neurological disorders. In seven patients, no variations were detected.

Conclusion:
In this single centre cohort study from India, genetic diagnosis could be established in 87% of patients with inherited neuropathy. The identified spectrum of genetic variations adds to the pool of existing data and provides a platform for validation studies in cell culture or animal model systems.
The emergent neurosurgical outcome of spontaneous intracranial hemorrhage in patients with chronic liver disease
Authors: Chang Tze-Wei , Lin Kuan-Ting Robin , Tsai Sheng-Tzung , Lee Chien-Hui 
Published: June 2022

Abstract

Objectives:
The influence of chronic liver disease (CLD) on emergent neurosurgical outcomes in patients with spontaneous intracerebral hemorrhage (ICH) remains unclear. CLD is usually associated with coagulopathy and thrombocytopenia, which contribute to a high rebleeding rate and poor prognosis after surgery. This study aimed to confirm the outcomes of spontaneous intracranial hemorrhage in patients with CLD after emergent neurosurgery.

Materials and Methods:
We reviewed the medical records of all patients with spontaneous ICH from February 2017 to February 2018 at the Buddhist Tzu Chi Hospital, Hualien, Taiwan. This study was approved by the Review Ethical Committee/Institutional Board Review of Hualien Buddhist Tzu Chi Hospital (IRB111-051-B). Patients with aneurysmal subarachnoid hemorrhage, tumors, arteriovenous malformations, and those younger than 18 years were excluded. Duplicate electrode medical records were also removed.

Results:
Among the 117 enrolled patients, 29 had CLD and 88 did not. There were no significant differences in essential characteristics, comorbidities, biochemical profile, Glasgow coma scale (GCS) score at admission, or ICH sites. The length of hospital stay (LOS) and length of intensive care unit stay (LOICUS) are significantly longer in the CLD group (LOS: 20.8 vs. 13.5 days, P = 0.012; LOICUS: 11 vs. 5 days, P = 0.007). There was no significant difference in the mortality rate between the groups (31.8% vs. 28.4%, P = 0.655). The Wilcoxon rank-sum test for liver and coagulation profiles between survivors and the deceased revealed significant differences in the international normalized ratio (P = 0.02), including low platelet counts (P = 0.03) between survivors and the deceased. A multivariate analysis of mortality found that every 1 mL increase in ICH at admission increased the mortality rate by 3.9%, and every reduction in GCS at admission increased the mortality rate by 30.7%. In our subgroup analysis, we found that the length of ICU stay and LOS are significantly longer in patients with CLD who underwent emergent neurosurgery: 17.7 ± 9.9 days versus 7.59 ± 6.68 days, P = 0.002, and 27.1 ± 7.3 days versus 16.36 ± 9.08 days, P = 0.003, respectively.

Conclusions:
From our study’s perspective, emergent neurosurgery is encouraged. However, there were more prolonged ICU and hospital stays. The mortality rate of patients with CLD who underwent emergent neurosurgery was not higher than that of patients without CLD.
Vertices of the Harder and Narasimhan polygons and the laws of large numbers
Authors: Grieve Nathan 
Published: June 2022

AbstractWe build on the recent techniques of Codogni and Patakfalvi (2021,Inventiones Mathematicae223, 811–894), which were used to establish theorems about semi-positivity of the Chow Mumford line bundles for families of$\mathrm {K}$-semistable Fano varieties. Here, we apply the Central Limit Theorem to ascertain the asymptotic probabilistic nature of the vertices of theHarder and Narasimhan polygons. As an application of our main result, we use it to establish a filtered vector space analogue of the main technical result of Codogni and Patakfalvi (2021,Inventiones Mathematicae223, 811–894). In doing so, we expand upon the slope stability theory, for filtered vector spaces, that was initiated by Faltings and Wüstholz (1994,Inventiones Mathematicae116, 109–138). One source of inspiration for our abstract study ofHarder and Narasimhan data, which is a concept that we define here, is the lattice reduction methods of Grayson (1984,Commentarii Mathematici Helvetic59, 600–634). Another is the work of Faltings and Wüstholz (1994,Inventiones Mathematicae116, 109–138), and Evertse and Ferretti (2013,Annals of Mathematics177, 513–590), which is within the context of Diophantine approximation for projective varieties.
Liver function status in Streptozotocin Induced Diabetic Rats Treated with Extracts of some Anti-diabetic Medicinal plants
Authors: Eluehike N. , Innih S. O. , Ukwuonwo-Ediale A. C. , Onoagbe I. O. 
Published: June 2022

The anti-diabetic effects of the plants Spondias mombin, Vernonia amgdalina, Annona murica and Nigella sativum have been reported in streptozotocin induced diabetic rats. This study assessed the liver function status of diabetic rats treated with these plant extracts. 42 rats were randomly divided into seven groups. Groups 1-3 served as the normal control, diabetic control and positive control groups respectively. Groups 4-7 were the Spondias mombin, Vernonia amgdalina, Annona murica and Nigella sativum extracts treated diabetic rats respectively. The liver markers assessed includes serum AST, ALT, ALP, total protein, albumin, bilirubin concentrations. The result showed that treatment with all plant extract resulted in a significant decrease in AST, ALT and ALP concentrations. However, a higher percentage decrease in ALP and ALT levels were observed in the Vernonia amgdalina treated diabetic rats when compared to other extract treated rats while Annona muricata treated rats gave the highest percentage reduction in AST concentration. Also treatment with V.amgdalina and Annona muricata gave the highest percentage reduction in total and conjugated bilirubin. Non-significant change was observed in protein and albumin levels. Histological evaluation revealed that treatment with extracts of Spondias mombin leaves, V. amgdalina leaves, Annona muricata leaves reverted the damage to the liver caused by STZ induction. V.amgdalina and Annona muricata are two plants to consider as powerful hepatoprotective agents.
PEMBERIAN TERAPI HYPNO-BREASTFEEDING DAN PERAWATAN KANGAROO MOTHER CARE (KMC) SEBAGAI STRATEGI CEPAT PEMULIHAN BAYI BERAT LAHIR RENDAH
Authors: Ringgi Maria Susana I. N. , Pora Yosefina Dhale , Keytimu Yosephina M. H. 
Published: June 2022

Beberapa ibu postpartum mengalami kesulitan dalam memproduksi ASI, volume ASI sedikit bahkan tidak keluar. Hal tersebut sering dialami oleh ibu-ibu primipara. Ibu primipara cenderung stress dan cemas karena kesulitan dalam proses adaptasi menjadi seorang ibu pertama kali dialami. Stress dan cemas pada ibu dapat mempengaruhi produksi oxytocin yang berdampak pada penurunan volume ASI. Therapy Hypno-breastfeeding dan Kangaroo Mother Care (KMC) merupakan upaya yang dipadukan sebagai strategi cepat memulihkan berat badan pada bayi berat lahir rendah. Tujuan dilakukan kombinasi kedua terapi ini adalah agar mampu membantu meningkatkan volume Air Susu Ibu pada ibu primipara dan ASI Eksklusif terjadi secara maksimal demi pemulihan Berat Badan pada Bayi Berat Lahir Rendah (BBLR) dapat terjadi dengan cepat. Metode Penelitian menggunakan Quasi Experimental Design dengan rancangan penelitian One Group Pre Test dan Post Test design dengan mengukur produksi volume air dan peningkatan berat badan pada Bayi Berat Lahir Rendah (BBLR). Subjek penelitian terdiri dari 1 kelompok ibu primipara dengan bayi BBLR. Kelompok intervensi diberikan therapy hypno-breastfeeding pada Ibu dan Kangaroo Mother Care untuk ibu dan bayi. Penilaian pada kelompok intervensi dilakukan pre-test dan post-test. Hasil penelitian menunjukkan melalui hasil analisis paired sampel T-Test diketahui nilai sig.(2-tailed) sebesar 0.000 < 0.05 artinya ada pengaruh terapi hypno-breastfeeding dan kangaroo mother care terhadap berat badan bayi dengan berat lahir rendah. Kesimpulan penelitian ini adalah Pemberian terapi hypno-breastfeeding dan kangaroo mother care terbukti memberi pengaruh terhadap peningkatan volume air susu pada ibu yang berdampak pada peningkatan berat badan bayi dengan berat lahir rendah secara signifikan.
PERBEDAAN PRODUKSI AIR SUSU IBU MELALUI PEMBERIAN EKSTRAK SARI KACANG HIJAU DAN KEDELAI DI PUSKESMAS LUMPUE KOTA PARE-PARE
Authors: Sufiani Andi , Saleha Sitti , Pramana Cipta 
Published: June 2022

Kacang hijau dan kedelai beserta kandungannya selama ini hanya digunakan secara empiris dan belum dibuktikan secara ilmiah mengenai kandungan kacang hijau dan kedelai yang dapat meningkatkan produksi ASI pada ibu menyusui dan memberikan bukti khasiat dari biji kacang hijau dan kedelai sebagai laktagogum (pelancar sekresi ASI). Tujuan penelitian adalah mengetahui Perbedaan Produksi Air Susu Ibu Nifas Melalui Pemberian Ekstrak Sari Kacang Hijau (Vigna radiata) dan Kedelai (Glycine Max) di UPTD Puskesmas Lumpue Kota Pare Pare. Desain penelitian yang di gunakan adalah quasi eksperimen dengan pendekatan two group pretest posttest design. dua kelompok masing-masing diberikan sari kacang hijau untuk kelompok 1 dan sari kedelai kelompok 2. Jumlah subjek adalah 50 responden masing-masing kelompok 25 responden, analisis uji yang dilakukan adalah uji t Wilcoxon, Mann Whitney dan uji t Independent. Hasil penelitian menunjukkan perbedaan rata-rata produksi ASI sebelum intervensi sari kacang hijau sebesar 108,0 ons dan intervensi sari kedelai yakni 103,6 ons, dan sesudah intervensi sari kacang hijau sebesar 171,6 ons dan intervensi sari kedelai yakni 200,8 ons. Uji Wilcoxon menunjukkan terdapatnya perbedaan bermakna produksi ASI sebelum dan sesudah intervensi pada kelompok pemberian sari kacang hijau (p = 0,000), pemberian sari kedelai (p = 0,000). Kesimpulannya adalah bahwa pemberian sari kacang hijau dan sari kedelai dapat meningkatkan produksi ASI. Sehingga sangat disarankan agar ibu menyusui untuk selalu mengkonsumsi kacang hijau atau sari kedelai.
PEMBERDAYAAN PENGRAJIN INDUSTRI OLAHAN HASIL LAUT “TERASI REBON” UNTUK PENGEMBANGAN POTENSI UNGGULAN DAERAH PESISIR BERDAYA SAING TINGGI DI TUBAN, JAWA TIMUR
Authors: Widyaningrum Mahmudah Enny , Widiana Muslichah Erma , Fattah Abdul , Soehardjoepri Soehardjoepri 
Published: June 2022

Salah satu produk unggulan dari hasil olahan ikan laut daerah pesisir Tuban yang terkenal adalah Terasi. Terasi adalah suatu jenis penyedap makanan berbentuk pasta, berbau khas hasil fermentasi udang, ikan atau campuran keduanya dengan garam dan bahan tambahan lain. Program Pengembangan Produk Unggulan daerah (PPPUD) berjudul Pemberdayaan Pengrajin Industri Olahan Hasil Laut “Terasi Rebon” untuk Pengembangan Potensi Unggulan Daerah Pesisir Berdaya Saing Tinggi di Tuban, Jawa-Timur. Permasalahan mitra ditinjau dari aspek produksi di Perusahaan perseorangan adalah Penguatan produksi: Dalam proses penjemuran bahan baku terasi memanfaatkan ketersediaan sinar matahari berdampak pada luasan penjemuran, dalam pengamatan ketidakbersihan proses yang berlangsung dan fluaktuatifnya udara panas. Selama ini dalam kegiatan operasional belum dilakukan dengan cara professional masih dengan sistem kekeluargaan dan belum adanya variasi rasa dan kemasan, Maka perlu penguatan fungsi operasional manajemen yang meliputi manajemen pemasaran, keuangan dan pajak, informasi, SDM dan produksi. Pengembangan produk kemasan dan rasa yang masih terbatas: Hasil kegiatan berupa “Tray dryer” Pengetahuan dan kemampuan dalam mengelola suatu usaha dengan pengetahuan fungsi operasional manajemen suatu ilmu pengetahuan dasar yang sangat diperlukan dalam mengelola usaha yang harus dimiliki segenap struktur organisasi yang ada di perusahaan mitra. Kemudian pengembangan e-commerce sebagai media informasi dan promosi produk mitra mengolah hasil laut pesisir rebon menjadi terasi dan menjadi produk unggulan Tuban sehingga mudah didapat di mana saja dengan harga yang ekonomis. Standarisasi berupa legalitas usaha dan produk. Hasil dari kegiatan ini memberikan peluang baru bagi mitra secara khusus untuk mengembangkan produk unggulan daerah Tuban sehingga mampu meningkatkan pengrajin pengolahan hasil laut.
IMPLEMENTASI COLOR DETECTION MENGGUNAKAN ALGORITMA MIDPOINT BERBASIS SISTEM OPERASI ANDROID
Authors: Amrullah Dimas Lutfhi , Swedia Ericks Rachmat , Cahyanti Margi , Dwi Septian M Ridwan 
Published: June 2022

Pengolahan citra selalu berhubungan erat dengan warna, namun ada beberapa metode pada yang mempunyai banyak kekurangan seperti metode Hue Saturation Value (HSV) yang hanya dapat mengenali 6 warna saja dan beberapa model pengenalan citra lainnya seperti Hue Saturation Lightness (HSL), Hue Saturation Intensity (HSI), Hue Chroma Lightness (HCL), dan masih banyak metode pengolahan citra lainnya yang penggunaannya tidak secara real time. Tujuan penelitian ini adalah merancang sebuah aplikasi pengolahan citra untuk mendeteksi warna berdasarkan kode heksa, kode Red, Green, Blue (RGB), dan pencatatan waktu pendeteksian yang dilakukan, mengimplementasikan Algoritma Midpoint ke dalam aplikasi, dan melakukan proses pengenalan citra tersebut secara real time. Algoritma Midpoint merupakan algoritma untuk mendapatkan titik tengah dari layar pada saat mengambil gambar objek menggunakan kamera smartphone. Titik tengah diperoleh dengan mendapatkan parameter yaitu koordinat ½ tinggi untuk sumbu y, dan ½ lebar untuk sumbu x sehingga dapat diperoleh titik pusat dari tengah layar. Dalam penelitian ini peneliti menggunakan bahasa pemrograman Java dengan JavaScript Object Nation (JSON) sebagai alat penyimpanan data dari warna yang digunakan untuk melakukan proses pengenalan warna Red, Green, Blue (RGB). Penelitian ini juga menambahkan metode Waterfall yaitu perencanaan, analisis, perancangan, implementasi, dan pengujian. Pada saat pengujian, peneliti menggunakan 15 data citra untuk diproses dan diharapkan adanya aplikasi ini dapat mempermudah pengguna dalam mengenali berbagai macam citra pada area di sekitar.
TRANSFORMASI SOSIAL BUDAYA MASYARAKAT PASCA PANDEMI COVID 19
Authors: Wignjosasono Ken Widyatwati 
Published: June 2022

Penerapan kebijakan new normal di masyarakat pasca pandemi Covid 19 menyebabkan terjadinya transformasi sosial budaya terutama pada interaksi sosial budaya di masyarakat. Penelitian ini membahas tentang transformasi sosial budaya di masyarakat sebagai akibat adanya pandemi Covid 19. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan analisis deskriptif. Tujuan penelitian ini adalah mengungkapkan terjadinya transformasi sosial budaya dalam kehidupan masyarakat sehari-hari sebagai dampak adanya penerapan kebijakan normal baru dan protokol kesehatan pasca pandemi Covid 19. Hasil penelitian ini menjelaskan bahwa penerapan kebijakan pembatasan kegiatan sosial di masyarakat selama pandemi Covid 19 menimbulkan banyak perubahan dalam pola dan perilaku masyarakat. Pandemi Covid 19 tidak hanya berdampak bagi pelajar dan mahasiswa tetapi juga menimbulkan akibat yang cukup signifikan terhadap interaksi soial di masyarakat. Penerapan pembatasan kegiatan sosial dan pemberlakuan tatanan baru atau new normal pasca pandemi Covid 19 berdampak pada berubahnya aturan dalam berinteraksi di masyarakat. Pemberlakuan kebijakan pembatasan kegiatan sosial masyarakat juga berdampak pada aturan bersosialisasi di masyarkat yang berubah dari luring menjadi daring seperti halal bihalal virtual, pengajian virtual, ataupun perayaan Natal bersama virtual. . Pembatasan kegiatan sosial masyarakat pasca pandemi Covid 19 menimbulkan adanya transformasi sosial budaya di masyarakat yang mengubah pola perilaku dan interaksi sosial masyarakat dalam kehidupan sehari-hari. Pandemi Covid-19 selain menimbulkan dampak negatif juga menimbulkan dampak positif karena memunculkan kreativitas baru di masyarakat. Masyarakat mampu memanfaatkan peluang bisnis di masa pandemi Covid 19 menjadi sumber pendapatan di tengah keterpurukkan ekonomi.