bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of a High‐Quality Organic‐Inorganic Hybrid Heterostructure and Its Photo‐response Performance
Authors: Zhang Yadan , Yu Guanghua , Xue Di , Lu Jie , Meng Xing , Yin Yao , Wang Qi , Wang Zi , Huang Lizhen , Chi Lifeng 
Published: September 2022

Comprehensive SummaryThe combination of metal oxide and organic semiconductor for constructing organic–inorganic hybrid heterostructure is promising to offer unique optoelectronic properties. However, the distinct difference in electron structure and processing technology of the two types of materials makes it usually difficult to fully deliver their complementary advantages. Herein, we report the construction of a high quality organic/In2O3 hybrid heterostructure presenting a good ambipolar transport with average electron mobility >1 cm2·V–1·s–1 and hole mobility up to 0.4 cm2·V–1·s–1, respectively, together with a high‐gain inverter. In addition, the incorporation with organic film on top of In2O3 remarkably reduces the dark current, enabling the realization of high photoconductivity response with photosensitivity of two magnitudes higher than that of pure In2O3. The photoconductor and phototransistor of the hybrid structure demonstrate high photoresponsivity >103 AW–1 and detectivity up to 1014 Jones, demonstrating the promising functionality of such a high quality hybrid heterostructure.
Mobile health app for monitoring allergic rhinitis and asthma in real life in Lithuanian MASK‐air users
Authors: Kvedarienė Violeta , Biliute Gabija , Didziokaitė Gabija , Kavaliukaite Loreta , Savonyte Agne , Rudzikaite‐Fergize Gabija , Puronaite Roma , Norkuniene Jolita , Emuzyte Regina , Dubakiene Ruta , Valiulis Arunas , Sousa‐Pinto Bernardo , Bedbrook Anna , Bousquet Jean 
Published: September 2022

AbstractBackgroundMASK‐air® is an app whose aim is to reduce the global burden of allergic rhinitis (AR) and asthma. A transfer of innovative practices was performed to disseminate and implement MASK‐air® in European regions. The aim of the study was to examine the implementation of the MASK‐air® app in Lithuanian adults in order to investigate (i) the rate of acceptance in this population, (ii) the duration of app use and (iii) the evaluation of the app after its use.MethodsIn a longitudinal study, Lithuanian adults with AR and/or asthma were recruited by allergists. They were informed about how to use MASK‐air® and were followed closely. They were reviewed after one to 3 months to evaluate satisfaction and were asked to continue using the app.ResultsAmong the 149 patients recruited (37.2 ± 10.4 years), 52.4% had rhinitis alone, 42.9% had rhinitis, asthma and/or conjunctivitis multimorbidity, and 2.7% isolated asthma. According to the MASK‐air® baseline questionnaire, 88.3% of patients considered that their symptoms were troublesome. Data were available for 102 (68.4%) patients. The duration of app usage in patients ranged from 1 to 680 days (median, 25–75 percentile: 54, 23.2–151 days). Forty‐two (41.1% of patients who were reviewed) patients agreed to share their opinion on MASK‐air®. Most users of the app were satisfied, from 46.5% thinking their allergy was treated more successfully to 90.4% recommending this app to other allergy sufferers.DiscussionWhen recommended by physicians, MASK‐air® was used for a longer period of time.
Type 1 vomeronasal receptors expressed in the olfactory organs of two African lungfish, Protopterus annectens and Protopterus amphibius
Authors: Nakamuta Shoko , Yamamoto Yoshio , Miyazaki Masao , Sakuma Atsuhiro , Nikaido Masato , Nakamuta Nobuaki 
Published: September 2022

AbstractLungfish are the fish related most closely to tetrapods. The olfactory organ of lungfish contains two distinct sensory epithelia: the lamellar olfactory epithelium (OE) and the recess epithelium (RecE). Based on their ultrastructural and histological characteristics, the lamellar OE and the RecE are considered to correspond respectively to the teleost OE and a primitive vomeronasal organ (VNO). In tetrapods, the OE and VNO have been shown to express different families of olfactory receptors; for example, in mammals, the OE expresses odorant receptors and trace amine‐associated receptors, while the VNO expresses type 1 (V1Rs) and type 2 (V2Rs) vomeronasal receptors. In the present study, we examined the expression of V1Rs in the olfactory organs of two African lungfish, Protopterus annectens and Protopterus amphibius. RNA sequencing and phylogenetic analyses identified 29 V1R genes in P. annectens and 50 V1R genes in P. amphibius. Most V1Rs identified in these lungfish were classified as the tetrapod‐type V1Rs initially found in tetrapods and distinct from fish‐type V1Rs. In teleost, which all lack a VNO, all olfactory receptors are expressed in the OE, while in Xenopus V1Rs are expressed exclusively in the OE, and not in the VNO. In situ hybridization analysis indicated that lungfish V1Rs were expressed mainly in the lamellar OE and rarely in the RecE. These results imply that V1R expression in lungfish represents an intermediate step toward the complete segregation of V1R expression between the OE and VNO, reflecting the phylogenetic position of lungfish between teleosts and amphibians.
Appearance estimation and reconstruction of glossy object surfaces based on the dichromatic reflection model
Authors: Tominaga Shoji , Yong Roseline Kim Fong 
Published: September 2022

AbstractWe propose an approach for estimating and reconstructing the material appearance of objects based on the spectral image data acquired in complex illumination environments with multiple light sources. The object appearance can be constructed with various material properties such as spectral reflectance, glossiness, and matteness under different geometric and spectral illumination conditions. The objects are assumed to be made of an inhomogeneous dielectric material with gloss or specularity. The color signals from the object surface are described by the standard dichromatic reflection model, which consists of diffuse and specular reflections, where the specular component has the same spectral composition as the illuminant. The overall appearance of objects is determined by a combination of chromatic factors, based on the reflectance and illuminant spectra, and shading terms, which represent the surface geometries of the surface illumination. Therefore, the appearance of a novel object can be reconstructed by modifying the chromatic factors and shading terms. The method for appearance estimation and reconstruction comprises four steps: (1) illuminant estimation, (2) spectral reflectance estimation, (3) shading term estimation and region segmentation, and (4) appearance reconstruction based on the reflection model. The proposed approach is validated in an experiment in which objects of different materials are illuminated using different light sources. We demonstrate typical reconstruction results with novel object appearances.
Batch Crystallization of Uric Acid: Modeling, Simulation, and the Impact of 3,7 – dimethylxanthine
Authors: Pradhane Ashish P. , Methekar Ravi N. , Agrawal Shailesh G. 
Published: September 2022

AbstractCrystallization of uric acid (UA) in the urine marks the beginning of UA urolithiasis. As previously reported, 3,7‐dimethylxanthine (DMX) has the capacity to impede the crystallization of UA. The main objective of the present study is to explore the impact of urinary pH and the addition of DMX as an inhibitor on the crystallization of UA. The presence of DMX results in a significant delay in the induction of UA crystallization. Also, a significant change in crystal habit and decrease in the crystal size is observed in the presence of DMX in synthetic urine. The UV spectrum of mother liquor and the FTIR spectra and PXRD patterns of UA crystals show that DMX does not get incorporated into the crystal lattice and impedes the process of crystallization being in the liquid phase. A mathematical model is also formulated by coupling the population balance equation with the mass balance. The kinetic parameters of growth and nucleation are estimated by fitting the model predictions with experimental values. A decrease in the mean value of nucleation and growth coefficient upon DMX addition also highlights the inhibition of UA crystallization.
Drosophila Relish‐mediated miR‐317 expression facilitates immune homeostasis restoration via inhibiting PGRP‐LC
Authors: Zhou Hongjian , Wu Shanshan , Liu Li , Liu Xiaoqi , Lan Siyu , Jiang Jiajun , Yang Wan , Jin Ping , Xia Xinyi , Ma Fei 
Published: September 2022

AbstractInnate immunity is the first and essential line for resisting pathogens, and the immune intensity and duration need to be strictly regulated to balance excessive or insufficient immune response. MicroRNAs (miRNAs) are crucial regulators of immune response in Drosophila, yet how immune‐related miRNAs are regulated remains poorly understood. Herein, we elucidated that the involvement of miR‐317 in NF‐κB transcription factor Relish mediated Drosophila Imd pathway in response to Gram‐negative (G‐) bacteria stimulation. Remarkably, the dynamic expression profiling for immune response indicated that Relish simultaneously enhances the expression of the effector antimicrobial peptide Dpt as well as miR‐317 post‐infection. Upregulation of miR‐317 could further down‐regulate the expression of PGRP‐LC, thereby forming a feedback in Drosophila Imd pathway to prevent over‐activation and restore immune homeostasis. Taken together, our study not only uncovers a novel Relish/miR‐317/PGRP‐LC regulatory axis to attenuate Drosophila Imd immune response and facilitate immune homeostasis restoration, but also provides vital insights into the complex mechanisms of animal innate immune regulation.
Contact with former adversaries through mass‐media is linked to forgiveness after dyadic and multi‐ethnic conflicts
Authors: Rupar Mirjana , Graf Sylvie , Voca Shpend 
Published: September 2022

AbstractFour correlational studies (NAlbanians = 232, NSerbs = 129, NBosniaks = 147, NCroats = 367) and one experimental study (NBosniaks = 682), investigated the link between mass‐mediated contact (i.e., information about former adversaries from the mass media) and forgiveness towards former adversaries in post‐conflict societies. Specifically, we tested the association between positive and negative mass‐mediated contact with one former adversary and forgiveness towards this former adversary (i.e., a primary transfer effect, Studies 1–4) and another former adversary (i.e., a secondary transfer effect, Studies 2–4). Positive mass‐mediated contact with one former adversary was linked to greater forgiveness towards that former adversary and another former adversary. Intergroup trust mediated the primary transfer effect of positive mass‐mediated contact, whereas generalization of trust and forgiveness from one former adversary to another mediated the secondary transfer effect. Our results underline the important role of positive but not negative mass‐mediated contact with former adversaries in reconciliation.
Identification of a dysregulated ceRNA network modulated by copy number variation‐driven lncRNAs in lung squamous cell carcinoma
Authors: Ding Jianyang , Huang Mingjiang , Huang Bin , Peng Xuyang , Wu Gongzhi , Peng Congxiong , Zhang Huaizhong , Mao Chaofan , Wu Xuhui 
Published: September 2022

AbstractLung cancer is primarily responsive for cancer death, and its progression is aggressively affected by copy number variation (CNV). Through bioinformatics approach, a ceRNA network of CNV‐driven lncRNAs in lung squamous cell carcinoma (LUSC) patients was constructed. Data on normal and LUSC tumor tissue from The Cancer Genome Atlas (TCGA)‐LUSC dataset were subjected to differential analysis, and differentially expressed lncRNAs (DElncRNAs), DEmiRNAs, and DEmRNAs were obtained. Based on TCGA‐LUSC, CNVs of normal and tumor tissue samples were then compared using a Chi‐square test, and lncRNAs were intersected based on their CNVs and expression alternation. In combination with the Kruskal‐Wallis test, CNV‐driven lncRNAs were acquired. Afterwards, miRNAs and mRNAs that interacted with CNV‐driven lncRNAs were obtained based on databases (LncBase, starBase, miRDB, mirDIP and TargetScan), DElncRNAs, DEmiRNAs and DEmRNAs, and correlation analysis. The acquired lncRNAs, miRNAs and mRNAs were subjected to Cytoscape software to construct a CNV‐driven ceRNA network, which involved 5 lncRNAs (MIR143HG, LINC00702, MIR22HG, RP11‐180 N14.1, RP11‐473 M20.9), 6 miRNAs (miR‐3200‐3p, miR‐1301‐3p, miR‐93‐3p, miR‐96‐5p, miR‐96‐5p, miR‐130b‐5p, miR‐205‐5p) and 80 mRNAs. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology enrichment analyses indicated that downstream mRNAs were mainly correlated with blood vessel development and T cell‐mediated immunity. In summary, we devoted to analyzing CNV‐related lncRNAs, mRNAs, and miRNAs in LUSC, thus clarifying 5 lncRNAs that may influence the malignant progression of LUSC. The ceRNA network regulated by these lncRNAs may be the novel pathogenesis of LUSC.
A dependent Bayesian Dirichlet process model for source apportionment of particle number size distribution
Authors: Baerenbold Oliver , Meis Melanie , Martínez‐Hernández Israel , Euán Carolina , Burr Wesley S. , Tremper Anja , Fuller Gary , Pirani Monica , Blangiardo Marta 
Published: September 2022

AbstractThe relationship between particle exposure and health risks has been well established in recent years. Particulate matter (PM) is made up of different components coming from several sources, which might have different level of toxicity. Hence, identifying these sources is an important task in order to implement effective policies to improve air quality and population health. The problem of identifying sources of particulate pollution has already been studied in the literature. However, current methods require an a priori specification of the number of sources and do not include information on covariates in the source allocations. Here, we propose a novel Bayesian nonparametric approach to overcome these limitations. In particular, we model source contribution using a Dirichlet process as a prior for source profiles, which allows us to estimate the number of components that contribute to particle concentration rather than fixing this number beforehand. To better characterize them we also include meteorological variables (wind speed and direction) as covariates within the allocation process via a flexible Gaussian kernel. We apply the model to apportion particle number size distribution measured near London Gatwick Airport (UK) in 2019. When analyzing this data, we are able to identify the most common PM sources, as well as new sources that have not been identified with the commonly used methods.
A deforming‐mesh finite‐element approach applied to the large‐translation and free‐surface scenario of fused deposition modeling
Authors: González Felipe A. , Elgeti Stefanie , Behr Marek , Auricchio Ferdinando 
Published: September 2022

AbstractA numerical study of the fused deposition modeling (FDM) process using a boundary‐conforming free‐surface finite element approach is performed. Due to the complexity of the FDM process, among all of its parts, we focus on the deposition and spreading of an individual filament. The polymer behavior, that is, the shear rate dependent and temperature‐dependent viscosity, is included by the Cross‐WLF viscosity model. The moving domain is addressed by the virtual region mesh update method, which, in the present article, is extended to free‐surface problems. The particularity of dividing the mesh domain into an activated and a deactivated domain makes it possible to handle large translatory mesh deformation. In this work, we make use of the level of detail offered by a boundary‐conforming approach regarding both topology accuracy and the imposition of boundary conditions in order to study the deposition of a single filament at a small scale. Parameters with a direct impact on the mechanical properties of the final object can be straightforwardly computed by a boundary‐conforming approach, for instance, the cross‐section, the contact area, the temperature distribution, and the heat fluxes over the surfaces. The presented approach is validated by a two‐dimensional benchmark test case before the numerical results of the three‐dimensional simulation of the filament deposition are shown.
Reply to “successful early use of anti‐SARS‐CoV‐2 monoclonal neutralizing antibodies in SARS‐CoV‐2 infected hematological patients—A Czech multicenter experience”: A case series of SARS‐CoV‐2 Omicron infection and aggressive lymphoma in the Sotrovimab era
Authors: Cassin Ramona , Rampi Nicolo , Anna Fidanza Cecilia , Muscatello Antonio , Mariani Bianca , Noto Alessandro , Rossi Francesca Gaia , Baldini Luca 
Published: September 2022

AbstractA prospective multicentre experience of early administration of anti‐SARS‐CoV‐2 spike protein neutralizing monoclonal antibodies (MA) with efficacy among patients with hematological malignancies and early‐stage COVID‐ 19 was reported by Weinbergerová et al. The study validated the safety and efficacy of MA early use among hematological patients with newly diagnosed early‐stage COVID‐19 in terms of alleviating infection course and decreasing mortality. However no reference to new variant (Delta and Omicron) or other MA (e.g., Sotrovimab) has been reported. We reported our monocentric experience of 8 aggressive lymphoma patients with Omicron infection, 7 of whom treated with this MA in our Institution between December 2021 and February 2022. Among the patients treated with Sotrovimab nobody experienced neither SARS‐CoV2 reactivation, nor other infectious events. One patients on active lymphoma treatment was hospitalized for pneumonia and treated with remdesivir. In 4/8 patients negativization of molecular swab occurred concomitantly to symptoms resolution with a median of 5.25 days, while the other 4 patients remained persistently positive with a median of 26.3 days. In this group, in order to maintain the chemo/chemoimmunotherapy (CT/CIT) dose‐density, lymphoma treatment was reassumed independently on molecular swab analysis. SARS‐CoV‐2 negativization occurred with a median of 7.7 days after the resumption of CT/CIT. The one patient treated with remdesivir, although still positive to molecular swab, restarted R‐COMP regimen at symptoms resolution too, but experienced an Omicron pneumonia exacerbation. This is the first case series reported in literature of patients affected by Omicron variant in which Sotrovimab seems to provide a resolution of COVID‐19 disease, even in patient with molecular swab positive persistence too. Patients with aggressive lymphoma histologies should not be deprived of the best available treatment of their disease after sotrovimab administration, even in the presence of a still positive Omicron swab.
Stability analysis of MHD radiative mixed convective flow in vertical cylindrical annulus: Thermal nonequilibrium approach
Authors: Shilpa B. , Leela V. , Rani Hari Ponnamma 
Published: September 2022

AbstractIn the present study, the influence of the induced magnetic field on the MHD mixed convective electrically conducting fluid flow inside the vertical cylindrical annulus is analyzed numerically. The heat transfer is presumed to be due to a combination of mixed convection and radiation. The stability of the flow is examined when the solid and fluid phases are not in local thermal equilibrium. The governing equations are solved numerically by both finite difference and finite element methods. To control the flow formation rate more accurately the induced magnetic field is also considered in this study. As the magnetic Prandtl number (Pm) and Hartmann number (M) get enhanced, the velocity and induced magnetic fields get retarded in the annulus due to the presence of drag‐like force, namely, the Lorentz force. When there is an increase in the mixed convection parameter the induced magnetic field gets enhanced. An increase in radiation parameter tends to decline the fluid temperature and reverse the behavior of the solid temperature. Increment in Pm decreases the wall shear stress near the conducting cylinder. Increasing values of porous, magnetic, and radiation parameters lead to an unstable system with smaller heat transfer coefficient values but the system gets stabilized for larger values of heat transfer coefficient. The results could be used as first‐hand information for comprehending and developing the thermal flow phenomenon in porous media. The obtained numerical results are in good accordance with the existing results. Using an artificial neural network, heat transfer characteristics are analyzed through mean square error and regression analysis.
A triple‐blind, randomized controlled trial, comparing combined letrozole and clomiphene versus only letrozole for ovulation induction in women with polycystic ovarian syndrome
Authors: Panda Soumya Ranjan , Sharmila Vijayan , Kalidoss Vinoth Kumar , Hota Smrutismita 
Published: September 2022

AbstractObjectiveTo evaluate the efficacy of combination treatment of letrozole and clomiphene citrate (CC) in comparison to that of letrozole alone to induce ovulation in infertile women with polycystic ovary syndrome (PCOS).MethodsThe current study was designed as a single‐center, double‐arm and triple‐blind, randomized, controlled trial. The study was prospectively registered with the clinical trials registry in India and was conducted after approval from the institutional ethics committee. Study patients were randomly assigned to treatment with either a combination of 2.5 mg of letrozole and placebo (n = 40) or a combination of 2.5 mg of letrozole and 50 mg of CC (n = 40) starting from cycle days 3 to 7 for a single treatment cycle.ResultsOvulation induction with combined letrozole and CC provided a higher ovulation rate, with a 35% absolute difference in its favor. The authors found an ovulation rate of 73% versus 38% (P = 0.003) for treatment with a combination drug and letrozole alone, respectively, while the ovulation rate ratio was 1.93 (95% CI, 1.24–3.01).ConclusionCombined treatment of letrozole and clomiphene may be considered as one of the first‐line ovulation induction agents for infertile women with PCOS because of its affordability and better safety profile.
Efficacy of combination therapy with pembrolizumab and axitinib for metastatic renal collecting duct cell carcinoma: A report on two cases
Authors: Tamada Shinji , Ikarashi Daiki , Tsuyukubo Takashi , Iwasaki Kazuhiro , Isurugi Kazumasa , Ono Sadahide , Takata Ryo , Fujisawa Hiromitsu , Obara Wataru 
Published: September 2022

IntroductionImmunotherapy‐based combinations have become the standard first‐line therapy for metastatic renal cell carcinoma. However, combined immunotherapy for renal collecting duct carcinoma had been reported, but its therapeutic efficacy had been unclear.Case presentationThe first case was a 62‐year‐old man treated with pembrolizumab and axitinib for renal collecting duct carcinoma with multiple bone metastases. After 7 months, the primary and metastatic lesions shrunk and were evaluated as a partial response. The second case was a 71‐year‐old man treated with pembrolizumab and axitinib for renal collecting duct carcinoma with lymph node and lung metastases. After 9 months, the primary and metastatic lesions shrunk and were evaluated as a partial response. In both cases, the tumor cell expression of programmed death ligand‐1 was negative, and CD4+ and CD8+ cells were observed in the tumor.ConclusionCombined immunotherapy with pembrolizumab and axitinib may be effective for metastatic renal collecting duct carcinoma.