bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Opioids for Adults With Pain From Cancer or Cancer Treatment: ASCO Guideline
Authors: Paice Judith A. , Bohlke Kari , Barton Debra , Craig David S. , El-Jawahri Areej , Hershman Dawn L. , Kong Lynn R. , Kurita Geana P. , LeBlanc Thomas W. , Mercadante Sebastiano , Novick Kristina L. M. , Sedhom Ramy , Seigel Carole , Stimmel Joanna , Bruera Eduardo 
Published: December 2022

PURPOSE To provide guidance on the use of opioids to manage pain from cancer or cancer treatment in adults. METHODS A systematic review of the literature identified systematic reviews and randomized controlled trials of the efficacy and safety of opioid analgesics in people with cancer, approaches to opioid initiation and titration, and the prevention and management of opioid adverse events. PubMed and the Cochrane Library were searched from January 1, 2010, to February 17, 2022. American Society of Clinical Oncology convened an Expert Panel to review the evidence and formulate recommendations. RESULTS The evidence base consisted of 31 systematic reviews and 16 randomized controlled trials. Opioids have primarily been evaluated in patients with moderate-to-severe cancer pain, and they effectively reduce pain in this population, with well-characterized adverse effects. Evidence was limited for several of the questions of interest, and the Expert Panel relied on consensus for these recommendations or noted that no recommendation could be made at this time. RECOMMENDATIONS Opioids should be offered to patients with moderate-to-severe pain related to cancer or active cancer treatment unless contraindicated. Opioids should be initiated PRN (as needed) at the lowest possible dose to achieve acceptable analgesia and patient goals, with early assessment and frequent titration. For patients with a substance use disorder, clinicians should collaborate with a palliative care, pain, and/or substance use disorder specialist to determine the optimal approach to pain management. Opioid adverse effects should be monitored, and strategies are provided for prevention and management. Additional information is available at www.asco.org/supportive-care-guidelines .
Laminin matrix adhesion regulates basal mammary epithelial cell identity
Authors: Englund Johanna I. , Bui Hien , Dinç Defne D. , Paavolainen Oona , McKenna Tomás , Laitinen Suvi , Munne Pauliina , Klefström Juha , Peuhu Emilia , Katajisto Pekka 
Published: December 2022

ABSTRACT
Mammary epithelium is a bilayered ductal network composed of luminal and basal epithelial cells, which together drive the growth and functional differentiation of the gland. Basal mammary epithelial cells (MECs) exhibit remarkable plasticity and progenitor activity that facilitate epithelial expansion. However, their activity must be tightly regulated to restrict excess basal cell activity. Here, we show that adhesion of basal cells to laminin α5-containing basement membrane matrix, which is produced by luminal cells, presents such a control mechanism. Adhesion to laminin α5 directs basal cells towards a luminal cell fate, and thereby results in a marked decrease of basal MEC progenitor activity in vitro and in vivo. Mechanistically, these effects are mediated through β4-integrin and activation of p21 (encoded by CDKN1A). Thus, we demonstrate that laminin matrix adhesion is a key determinant of basal identity and essential to building and maintaining a functional multicellular epithelium.
A transit map for micro-scale urban development in Alexandria, Egypt
Authors: H. Seoudy Mohamed , El Menshawy Adel , El Adawy Amr 
Published: December 2022

Background: Due to Egypt's strategic location among countries, transportation is one of the most significant development sectors because it plays a major part in today's economy and society and has a large influence on growth and employment. Over the years, the Egyptian General Organisation of Physical Planning (GOPP) has prepared strategic general urban plans in collaboration with local and foreign organisations, including transportation plans. The constant focus of authorities on strategic plans and their inability to implement them on schedule are a major issue. In other words, they always take development from a distant perspective and do not deal with the main problem that exists within cities, as the existing micro-scale transit built environments (MSTBEs) of cities are not ready due to a lack of transit-oriented communities (TOCs), sustainably developed transit supply systems, and mobility hubs. Methods: The "Enhanced MSTBE Phases" methodology is used for the key elements of the study design used in this research, depending on data collection, approvals, techniques, and analysis methods. As a case study, these key elements are in the documentation, analysis, and development of the Muharram Bek El Mowkaf El Gedid Mobility Hub (MBMH) and the 800 m radius around it. Results: The results indicate that Enhanced MSTBE Phases led to the establishment of the MBMH and the 800 m radius surrounding it as a sustainable MSTBE in Alexandria, Egypt, which is chosen as the case study. Conclusions: The development of this MSTBE is a catalyst for future effects that will have a long-term impact on meso-scale and, ultimately, macro-scale transit built environments.
Electronic signature and attestation in conveyancing practice: A Malaysian legal perspective
Authors: Wong Hua Siong , Muhamad Mohd Munzil 
Published: December 2022

Background The Corona Virus Disease 2019 (COVID-19) pandemic brought about an unprecedented disruption to global business activities. Physical face-to-face activities must be restricted due to movement control order (MCO). The clients are required to sign the documents physically in the presence of the solicitor who must subsequently attest to the signature of the clients. The issue arises whether electronic signature (e-signature) and attestation are permissible under the laws of Malaysia. The aim of this research was to study the legality of e-signature and attestation in conveyancing practice in Malaysia and subsequently to propose recommendations to overcome these issues. Methods This is qualitative study and not an empirical study. The data was collected by library-based research from various primary and secondary data sources, including case law in Malaysia, written statutes, publication of journal and article. Results The Digital Signatures Act 1997 (DSA) and the Electronic Commerce Act 2006 (ECA) have legalised e-signatures. The DSA is the law that governs the digital signatures in Malaysia. ECA has listed a few documents which are not legally accepted if signed electronically, namely Power of Attorney, the Wills and codicils, the Trusts, and negotiable instruments. However, with regards to the issue of attestation of these documents, there are no clear laws which govern the attestation. The legal issue arises when the lawyers who have attested these documents are liable to be called as witness under the Evidence Act 1950 to testify their signature if these documents are tendered as evidence in any court proceedings. Conclusion The laws in Malaysia have provided sufficient provisions for e-signatures but not the issue of attestation via online. Thus, it is suggested that there is a need for unique legal framework for attestation via online in Malaysia.
Probiotics for preventing or treating COVID-19; a systematic review of research evidence and meta-analyses of efficacy for preventing death, severe disease, or disease progression
Authors: Allen Jawara , Evans Carlton A. , Datta Sumona 
Published: December 2022

Background: COVID-19 variants threaten health globally. Despite improving vaccines and treatments, there is an urgent need for alternative strategies to prevent or reduce the severity of COVID-19. Potential strategies include probiotics, which are safe, inexpensive, globally available and have been studied previously in relation to respiratory infections. Methods: We performed a systematic review and meta-analyses of experimental, trial or observational research evidence evaluating probiotics compared with control groups for preventing or treating COVID-19. We searched PubMed, ProQuest, Google Scholar and Web of Science bibliographic databases for studies published until December 6, 2021. We then performed meta-analyses for outcomes reported consistently across studies. Outcomes reported inconsistently or not amenable to meta-analysis were compared descriptively. Results: We identified six eligible studies, which were all published in 2020 and 2021: one randomized controlled trial and five retrospective cohort studies. The only randomized controlled trial reported that groups that ingested probiotics compared with control groups that did not ingest probiotics did not differ significantly with respect to death, severe disease requiring admission to an intensive care unit or disease progression (all p>0.5). The five retrospective cohort studies reported various apparently beneficial and harmful COVID-19 outcome associations with probiotic ingestion. Meta-analyses revealed no significant associations between probiotic use and death, severe disease, or disease progression caused by COVID-19. Descriptive data revealed that probiotic ingestion was associated with a trend towards worsened duration of hospital stay, improvements in measures of respiratory condition and worsened disease duration. The evidence for these contradictory associations was weak because all studies were prone to bias and none were considered to be of high quality. Conclusions: Current evidence does not suggest that probiotics affect COVID-19 severity or mortality. However, additional higher quality studies need to be conducted to definitively determine if probiotics would be a useful adjunctive treatment for COVID-19.
THE INFLUENCE OF INTERNET ADDICTION ON DEPRESSION INDICATORS IN MEDICAL UNIVERSITY STUDENTS
Authors: Moskalenko Olga L. , Tereshchenko Sergey Yu. , Yaskevich Roman A. 
Published: December 2022

The purpose of the study. To study the effect of internet-addiction on depression scores among medical university students.
Materials and methods. The study involved 145 students of both sexes studying at a medical university. The CIAS scale used to assess the level of internet-addiction. Analysis of the frequency and severity of depression carried out using the HADS scale.
Results. It found that a pronounced and stable pattern of internet-dependent behavior on the CIAS scale was detected in 8,2% of the surveyed medical students. Symptoms of depression of varying severity were twice as common among female medical students. When studying the influence of internet-dependent behavior on depression indicators, it was found that among students with Internet addiction, people with symptoms of depression of varying severity were more common, compared with students who are prone to internet-addiction and do not have addiction.
Conclusion. The study revealed the presence of a high level of depressive disorders in students with internet-addiction studying at a medical university.
INTEGRATIVE SEMANTIC MAP AS AN ILLUSTRATIVE AND SCHEMATIC BASIS FOR THE DEVELOPMENT OF A PROFESSIONALLY SIGNIFICANT ENGLISH-LANGUAGE THESAURUS OF THE THEMATIC FIELD “LAW”
Authors: Kochetkova Svetlana Y. , Kurchenkova Elena A. 
Published: December 2022

The authors of the article consider integrative semantic mapping as an illustrative and schematic basis for the law students’ development of a professionally oriented English-language thesaurus of the topical field “Law”. The aim of the research is to study further development of professional and communicative English-language competence which allows ensuring the implementation of pragmatic and professional communicative tasks in simulated situations of entering into legal relationship by the students.
Methodology. The methodological framework for the research is the cognitive and generalizing methods, such as the theoretical analysis of research works in linguodidactics, pedagogy, cognitive linguistics, and the prognostic methods. The research material was an educational and methodological complex on the discipline “Legal English”, used as part of the Bachelor’s degree program 40.03.01 “Jurisprudence”.
Results. The paper analyzes an algorithm for the development of abilities and skills of linguo-cognitive processing of professionally significative highly legal English texts of a static nature (for intermediate and upper-intermediate students), and English-language videos of a dynamic nature of the genre “courtroom drama” (for advanced and proficient students) using integrative semantic maps. Analyzing their application features allows us to emphasize their main function, which consists in optimizing the development of information about the law enforcement and legal proceedings in English-speaking countries, necessary for the effective intercultural communication of future practitioners in various branches of law.
Conclusion. Forming and developing the English-language thesaurus of a professional lawyer is one of important areas of modern linguodidactics. It has been proved that the optimization of this process has become possible thanks to the use of new learning technologies, in particular, integrative semantic mapping as a tool for verbalization of acquired knowledge, which allows consciously applying cognitively mastered information, competently verbalizing it in intercultural professional communication, preventing and eliminating possible communication failures.
Truthful Mechanisms for Two-Sided Markets via Prophet Inequalities
Authors: Braun Alexander , Kesselheim Thomas 
Published: December 2022

We design novel mechanisms for welfare maximization in two-sided markets. That is, there are buyers willing to purchase items and sellers holding items initially, both acting rationally and strategically in order to maximize utility. Our mechanisms are designed based on a powerful correspondence between two-sided markets and prophet inequalities. They satisfy individual rationality, dominant-strategy incentive compatibility, and budget balance constraints and give constant factor approximations to the optimal social welfare. We improve previous results in several settings. Our main focus is on matroid double auctions. Here, sellers hold identical items, and the set of buyers that obtain an item needs to be independent in a matroid. We construct two mechanisms, the first being a 1/3 approximation of the optimal social welfare-satisfying strong budget balance and requiring the agents to trade in a customized order and the second being a 1/2 approximation weakly budget balanced and able to deal with online arrival determined by an adversary. In addition, we construct constant factor approximations in two-sided markets with identical items when buyers need to fulfill a knapsack constraint. Also, in combinatorial double auctions with heterogeneous items, where buyers have valuation functions over item bundles instead of being interested in only one item, using similar techniques, we design a mechanism that is a 1/2 approximation of the optimal social welfare, is strongly budget balanced, and can deal with the online arrival of agents in an adversarial order. Funding: A. Braun was funded by the Deutsche Forschungsgemeinschaft [Grant 437739576].
Real-time acquisition and enhancement of remote acoustic signals by a free-space monostatic homodyne laser Doppler vibrometer
Authors: Zhi Yanan , Zou Yu , Tian Kehan , Sun JianFeng 
Published: December 2022

This paper systematically presents the design and performance of an extremely sensitive
1.55-µm free-space monostatic laser Doppler vibrometer (LDV) using
optical homodyne detection for real-time acquisition and enhancement
of the remote acoustic signals. The phase shifts produced by laser
light scattered off a remote target carries the extremely tiny
vibration displacement information of the target’ surface motivated by
the acoustic source around and is demodulated using the optical
in-phase/quadrature demodulator. The real-time acquisitions of the
remote acoustic signals, including the sinusoidal signal and the
speech signal at the target distance of 100 m, is performed
between two buildings. The real-time speech enhancement of remote
speech signals is also carried out by the different algorithms based
on the short-time spectral magnitude, and the comprehensible speech
signals can be reconstructed. The results demonstrate that the
designed free-space monostatic homodyne LDV has a low system
background noise and can offer high precision for the uncooperative
targets in the real-time acquisition of the remote acoustic
signal.
Output characteristics of 3–8  µm mid-infrared source based on BaGa4Se7 crystal
Authors: Li Weifan , Cheng Naijun , Qi Feng , Yao Jiyong , Guo Liyuan , Liu Pengxiang 
Published: December 2022

An optical parametric oscillator based on

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crystal is constructed for use as a
3–8 µm mid-infrared source. The output
characteristics of the light source, including wavelength tuning, beam
quality, and energy stability, are studied, which are usually
concerned differently in spectral analysis, imaging, and laser
processing. When the light source operates far from the threshold, the
mid-infrared output is poor in beam quality and good in energy
stability, and the contradiction should be addressed in practice. The
results provide guidance on the selection of operating parameters and
performance optimization for the application of the

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based mid-infrared source in various
settings.
Reactive focal drug administration associated with decreased malaria transmission in an elimination setting: Serological evidence from the cluster-randomized CoRE study
Authors: Bridges Daniel J. , Miller John M. , Chalwe Victor , Moonga Hawela , Hamainza Busiku , Steketee Richard W. , Mambwe Brenda , Mulube Conceptor , Wu Lindsey , Tetteh Kevin K. A. , Drakeley Chris , Chishimba Sandra , Mwenda Mulenga , Silumbe Kafula , Larsen David A. 
Published: December 2022

Efforts to eliminate malaria transmission need evidence-based strategies. However, accurately assessing end-game malaria elimination strategies is challenging due to the low level of transmission and the rarity of infections. We hypothesised that presumptively treating individuals during reactive case detection (RCD) would reduce transmission and that serology would more sensitively detect this change over standard approaches. We conducted a cluster randomised control trial (NCT02654912) of presumptive reactive focal drug administration (RFDA–intervention) compared to the standard of care, reactive focal test and treat (RFTAT—control) in Southern Province, Zambia—an area of low seasonal transmission (overall incidence of ~3 per 1,000). We measured routine malaria incidence from health facilities as well as PCR parasite prevalence / antimalarial seroprevalence in an endline cross-sectional population survey. No significant difference was identified from routine incidence data and endline prevalence by polymerase chain reaction (PCR) had insufficient numbers of malaria infections (i.e., 16 infections among 6,276 children) to assess the intervention. Comparing long-term serological markers, we found a 19% (95% CI = 4–32%) reduction in seropositivity for the RFDA intervention using a difference in differences approach incorporating serological positivity and age. We also found a 37% (95% CI = 2–59%) reduction in seropositivity to short-term serological markers in a post-only comparison. These serological analyses provide compelling evidence that RFDA both has an impact on malaria transmission and is an appropriate end-game malaria elimination strategy. Furthermore, serology provides a more sensitive approach to measure changes in transmission that other approaches miss, particularly in very low transmission settings.
Trial Registration: Registered at www.clinicaltrials.gov (NCT02654912, 13/1/2016).
Commemorative Literary Portrait of V. M. Shukshin
Authors: Bogumil Tatiana 
Published: December 2022

The article focuses on the memorial lyrics about V. M. Shukshin as a way to model his image as a writer, director and actor. The focus is on the poetic obituaries by V. Vysotsky, A. Voznesensky, E. Yevtushenko, R. Rozhdestvensky as precedent texts for the subsequent memorial tradition which developed into a corpus of works by less known poets. The memorial "supertext" on Shukshin includes a regional component associated with the "native place" of the writer, as well as more universal motifs of life and cinema in their contradictory unity, creative method (author “from grassroots”), literary evolution (ancestors and successors). The literary portrait of Shukshin is built on symbolic details: cheekbones, kersey boots, guilder rose, birch, etc. The poets mention the films that are significant in his biography: the prophetic “Kalina Krasnaya”, the fatal “They Fought for the Motherland”, unfilmed “Stepan Razin”. The pragmatic aspect of commemorative practices reveals a negative component: a parasitic self-affirmation in culture through a public commemoration of a departed celebrity.
RELATIONSHIP BETWEEN CREATIVITY, BUSINESS NETWORK AND INDEPENDENCE IN ENTREPRENEURSHIP OF ACEH YOUTH
Authors: BADARUDDIN BADARUDDIN , AZIS Nasir , SOFYAN Hizir , BASRI Hasan 
Published: December 2022

The purpose of this study was to determine the effect of creativity, business Networks and entrepreneurial independence among young people in Aceh. The location of this study was conducted on young and medium-sized business actors in Aceh, the sampling method used non-probability sampling method with purposive sampling technique so that the number of respondents obtained were 170 young entrepreneurs in Aceh. The analytical tool used is Structural Equation Modeling in the model and testing hypotheses and testing a series of relatively complex relationships simultaneously. The results showed that creativity support, business network support, and independence support had a significant influence on entrepreneurship among young people in Aceh. From the results of this study it can be seen that each indicator that forms a latent variable shows the results that meet the criteria, namely the CR value above 1.96 with P-value that is smaller than 0.05.
PUBLIC SPENDING AND ECONOMIC WELFARE IN ECOWAS COUNTRIES: DOES LEVEL OF DEVELOPMENT MATTER?
Authors: ALIMI R. Santos 
Published: December 2022

Conflicting views on the sign of the relationship between government size and economic development have resulted into the testing of non-monotonic relationship in the literature. Therefore, the total effect of growing public spending on economic development is ambiguous. This study investigated how government size affect economic development and determine the optimal government size that promotes economic development in ECOWAS countries. The study employed secondary data covering the period 1986 to 2018. Data on Gross Domestic Product per capita, government size, population growth rate, inflation rate, gross fixed capital formation and financial development variables were sourced from World Development indicator database. The study constructed social welfare function as development indicator. Data were analysed using Least Absolute Deviation (LAD) regression and quantile regression (QR). The findings showed that quantile regression estimates are negative and significant (p < 0.05) in low quantiles, thus suggesting that deleterious effect of government size is more pronounced among countries with low level of economic development.