bluuebunny/crossref_metadata_2025_split huggingface dataset:
2-year outcomes of phased radiofrequency ablation for atrial fibrillation with the second-generation PVAC Gold ablation catheter
Authors: Klaver M. N. , Wintgens L. I. S. , Wijffels M. C. E. F. , van Dijk V. F. , Alipour A. , Chaldoupi S. M. , Derksen R. , Peper J. , Balt J. C. , Boersma L. V. A. 
Published: May 2022

Abstract
Purpose
The second-generation multi-electrode catheter, PVAC Gold, was designed to improve the safe delivery of phased radiofrequency energy using a “single shot” approach for pulmonary vein isolation (PVI), while retaining efficacy. This large registry presents long-term performance in a daily practice setting.

Methods
A total of 1011 patients undergoing first time ablation for atrial fibrillation (AF) using PVAC Gold were included, 639 patients with PVI for paroxysmal AF (PAF PVI) and 372 patients with persistent or long-standing persistent AF, divided into 175 patients receiving PVI only (PersAF PVI) and 197 patients receiving PVI with additional substrate ablation (PersAF PVI +).

Results
At 24-month follow-up, single procedure freedom from atrial tachyarrhythmia (ATA) was 58% (368/639) in the PAF PVI group, 44% (77/175) in the PersAF PVI group, and 29% (57/197) in the PersAF PVI + group. Allowing one repeat procedure in 33% of patients, 76%, 65%, and 54% were free from ATA at 24 months, respectively. Pulmonary vein reconnection was observed in 98% of patients with recurrent arrhythmia after PVI.

Conclusions
Although phased RF ablation with PVAC Gold is quick and safe, the efficacy outcomes are modest compared to current mainstream ablation strategies.
A Discontinuous Galerkin Method for Approximating the Stationary Distribution of Stochastic Fluid-Fluid Processes
Authors: Bean Nigel , Lewis Angus , Nguyen Giang T. , O’Reilly Małgorzata M. , Sunkara Vikram 
Published: May 2022

AbstractThe stochastic fluid-fluid model (SFFM) is a Markov process $$\{(X_t,Y_t,\varphi _t),t\ge 0\}$$

{

(

X
t

,

Y
t

,

φ
t

)

,
t
≥
0
}

, where $$\{\varphi _t,{t\ge 0}\}$$

{

φ
t

,

t
≥
0

}

is a continuous-time Markov chain, the first fluid, $$\{X_t,t\ge 0\}$$

{

X
t

,
t
≥
0
}

, is a classical stochastic fluid process driven by $$\{\varphi _t,t\ge 0\}$$

{

φ
t

,
t
≥
0
}

, and the second fluid, $$\{Y_t,t\ge 0\}$$

{

Y
t

,
t
≥
0
}

, is driven by the pair $$\{(X_t,\varphi _t),t\ge 0\}$$

{

(

X
t

,

φ
t

)

,
t
≥
0
}

. Operator-analytic expressions for the stationary distribution of the SFFM, in terms of the infinitesimal generator of the process $$\{(X_t,\varphi _t),t\ge 0\}$$

{

(

X
t

,

φ
t

)

,
t
≥
0
}

, are known. However, these operator-analytic expressions do not lend themselves to direct computation. In this paper the discontinuous Galerkin (DG) method is used to construct approximations to these operators, in the form of finite dimensional matrices, to enable computation. The DG approximations are used to construct approximations to the stationary distribution of the SFFM, and results are verified by simulation. The numerics demonstrate that the DG scheme can have a superior rate of convergence compared to other methods.
Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC50 Values in Aging and Alzheimer’s Disease, Using the Physiologically Based LeiCNS-PK3.0 Model
Authors: Saleh Mohammed A. A. , Bloemberg Julia S. , Elassaiss-Schaap Jeroen , de Lange Elizabeth C. M. 
Published: May 2022

Abstract
Background
Very little knowledge exists on the impact of Alzheimer’s disease on the CNS target site pharmacokinetics (PK).

Aim
To predict the CNS PK of cognitively healthy young and elderly and of Alzheimer’s patients using the physiologically based LeiCNS-PK3.0 model.

Methods
LeiCNS-PK3.0 was used to predict the PK profiles in brain extracellular (brainECF) and intracellular (brainICF) fluids and cerebrospinal fluid of the subarachnoid space (CSFSAS) of donepezil, galantamine, memantine, rivastigmine, and semagacestat in young, elderly, and Alzheimer’s patients. The physiological parameters of LeiCNS-PK3.0 were adapted for aging and Alzheimer’s based on an extensive literature search. The CNS PK profiles at plateau for clinical dose regimens were related to in vitro IC50 values of acetylcholinesterase, butyrylcholinesterase, N-methyl-D-aspartate, or gamma-secretase.

Results
The PK profiles of all drugs differed between the CNS compartments regarding plateau levels and fluctuation. BrainECF, brainICF and CSFSAS PK profile relationships were different between the drugs. Aging and Alzheimer’s had little to no impact on CNS PK. Rivastigmine acetylcholinesterase IC50 values were not reached. Semagacestat brain PK plateau levels were below the IC50 of gamma-secretase for half of the interdose interval, unlike CSFSAS PK profiles that were consistently above IC50.

Conclusion
This study provides insights into the relations between CNS compartments PK profiles, including target sites. CSFSAS PK appears to be an unreliable predictor of brain PK. Also, despite extensive changes in blood-brain barrier and brain properties in Alzheimer’s, this study shows that the impact of aging and Alzheimer’s pathology on CNS distribution of the five drugs is insignificant.
Transition Metal Hexacyanoferrate(II) Complexes as Catalysts in the Ring-Opening Copolymerization of CO2 and Propylene Oxide
Authors: Penche Guillermo , González-Marcos M. Pilar , González-Velasco Juan R. 
Published: May 2022

AbstractThe catalytic activity of four transition metal hexacyanoferrate(II) complexes (Ni2[Fe(CN)6], Co2[Fe(CN)6], KFe[Fe(CN)6] and Zn2[Fe(CN)6]) in the ring-opening copolymerization (ROCOP) of CO2 and propylene oxide (PO) is reported here for the first time and compared with that of other hexacyanometallate compounds. Complexes were prepared by coprecipitation employing tert-butanol as complexing agent. X-ray diffraction, Fourier-transform infrared spectroscopy, thermogravimetric analysis, elemental analysis, X-ray fluorescence, scanning electron microscopy, transmission electron microscopy and N2 physisorption were used to confirm the identity of the obtained materials. Except for Zn2[Fe(CN)6], which showed an amorphous nature, the complexes were constituted by aggregates of cubic nanocrystals with intra-crystalline micropores and inter-crystalline mesopores. Gas–solid phase titration with NH3 revealed the high potential of hexacyanoferrates as Lewis acid catalysts. In the case of Zn2[Fe(CN)6], the lack of structural organization led to an extremely high density of acid sites (43 μmol m−2). The resulting copolymers were analyzed via nuclear magnetic resonance spectroscopy and gel permeation chromatography. The studied transition metal hexacyanoferrate(II) catalysts showed mild activity in the target reaction, giving rise to polyethercarbonates with moderate CO2 content (9.3–18.1 wt%), random configuration (67.0–92.4% of polyethercarbonate linkages), modest molecular weights (MW, g mol−1 = 3400–20,200) and high dispersity (ĐM = 4.0–5.4). Cyclic propylene carbonate (PC) was also produced (1.4–19.8 wt%). Among all, the Co2[Fe(CN)6] complex stands as a potential catalyst for CO2/PO ROCOP due to its high CO2 uptake, selectivity and molecular weight of the obtained copolymer.
Reattachable fiducial skin marker for automatic multimodality registration
Authors: Mittmann Benjamin J. , Seitel Alexander , Echner Gernot , Johnen Wiebke , Gnirs Regula , Maier-Hein Lena , Franz Alfred M. 
Published: May 2022

Abstract
Purpose
Fusing image information has become increasingly important for optimal diagnosis and treatment of the patient. Despite intensive research towards markerless registration approaches, fiducial marker-based methods remain the default choice for a wide range of applications in clinical practice. However, as especially non-invasive markers cannot be positioned reproducibly in the same pose on the patient, pre-interventional imaging has to be performed immediately before the intervention for fiducial marker-based registrations.

Methods
We propose a new non-invasive, reattachable fiducial skin marker concept for multi-modal registration approaches including the use of electromagnetic or optical tracking technologies. We furthermore describe a robust, automatic fiducial marker localization algorithm for computed tomography (CT) and magnetic resonance imaging (MRI) images. Localization of the new fiducial marker has been assessed for different marker configurations using both CT and MRI. Furthermore, we applied the marker in an abdominal phantom study. For this, we attached the marker at three poses to the phantom, registered ten segmented targets of the phantom’s CT image to live ultrasound images and determined the target registration error (TRE) for each target and each marker pose.

Results
Reattachment of the marker was possible with a mean precision of 0.02 mm ± 0.01 mm. Our algorithm successfully localized the marker automatically in all ($$n=201$$

n
=
201

) evaluated CT/MRI images. Depending on the marker pose, the mean ($$n=10$$

n
=
10

) TRE of the abdominal phantom study ranged from 1.51 ± 0.75 mm to 4.65 ± 1.22 mm.

Conclusions
The non-invasive, reattachable skin marker concept allows reproducible positioning of the marker and automatic localization in different imaging modalities. The low TREs indicate the potential applicability of the marker concept for clinical interventions, such as the puncture of abdominal lesions, where current image-based registration approaches still lack robustness and existing marker-based methods are often impractical.
Endocrine disrupting chemicals: effects on pituitary, thyroid and adrenal glands
Authors: Egalini Filippo , Marinelli Lorenzo , Rossi Mattia , Motta Giovanna , Prencipe Nunzia , Rossetto Giaccherino Ruth , Pagano Loredana , Grottoli Silvia , Giordano Roberta 
Published: May 2022

Abstract
Background
In recent years, scientific research has increasingly focused on Endocrine Disrupting Chemicals (EDCs) and demonstrated their relevant role in the functional impairment of endocrine glands. This induced regulatory authorities to ban some of these compounds and to carefully investigate others in order to prevent EDCs-related conditions. As a result, we witnessed a growing awareness and interest on this topic.

Aims
This paper aims to summarize current evidence regarding the detrimental effects of EDCs on pivotal endocrine glands like pituitary, thyroid and adrenal ones. Particularly, we directed our attention on the known and the hypothesized mechanisms of endocrine dysfunction brought by EDCs. We also gave a glimpse on recent findings from pioneering studies that could in the future shed a light on the pathophysiology of well-known, but poorly understood, endocrine diseases like hormone-producing adenomas.

Conclusions
Although intriguing, studies on endocrine dysfunctions brought by EDCs are challenging, in particular when investigating long-term effects of EDCs on humans. However, undoubtedly, it represents a new intriguing field of science research.
Perceived and actual travel times in a multi-modal urban public transport network: comparing survey and AVL data
Authors: Brands Ties , Dixit Malvika , Zúñiga Edgard , van Oort Niels 
Published: May 2022

AbstractPerceived travel times of travelers are usually longer than actually realized travel times, implying that passengers’ experience of travel time savings is different from objectively calculated savings. This study provides additional empirical evidence on this topic, by comparing the passengers’ perceived travel times reported in an (online) survey with their corresponding actual in-vehicle travel times from Automatic Vehicle Location (AVL) data. The case study involves the metro, tram and bus network of Amsterdam, the Netherlands. On average, travelers perceive their travel time to be 1.9 min (11%) longer than their actual realized travel time. The perceived values match the scheduled values slightly better than the actually realized values. Furthermore, we found a larger travel time over-perception for metro compared to tram and bus. This is a counter-intuitive result, since the metro has been found to have a less negative travel time perception than busses in the public transport choice modelling literature. When the travel purpose is considered, the leisure time purposes recreation and shopping have a significantly smaller travel time over-perception than work-related journeys. Opening a new metro line did not have a significant influence on the travel time perception of travelers in Amsterdam.
How COVID-19 impacted surplus food redistribution in the Netherlands: An explorative study
Authors: Rao Madhura , Bast Aalt , de Boer Alie 
Published: May 2022

AbstractThe COVID-19 pandemic has been detrimental to food security globally. The Netherlands, despite its advanced stage of development, saw a surge in food insecurity among its most vulnerable citizens. Dutch food aid is managed by private charities and social organisations that often aim to address the problems of food insecurity and food waste by redistributing surplus food that is safe to consume. This paper investigates how the pandemic impacted surplus food redistribution in the country by employing an Exploratory-Descriptive-Qualitative approach. This is done by analysing data from interviews with relevant stakeholders involved in redistributing surplus food in the Netherlands as well as media reports on the topic. Our findings indicate that the interviewed organisations experienced drastic fluctuations in supply and demand. To cope with these changes, rapid organisational and supply chain innovation was observed. Next to this, there seems to have been disproportionate negative impact on smaller charities in comparison to bigger, better established organisations. Based on our findings, we discuss what the future of surplus food distribution in the Netherlands might look like and why changes made during the pandemic must be well documented and carefully analysed.
Implementing a preimplantation proteomic approach to advance assisted reproduction technologies in the framework of predictive, preventive, and personalized medicine
Authors: Kanaka Vasiliki , Proikakis Stavros , Drakakis Petros , Loutradis Dimitrios , Tsangaris George Th. 
Published: May 2022

AbstractThe evolution of the field of assisted reproduction technology (ART) in the last 40 years has significantly contributed to the management of global infertility. Despite the great numbers of live births that have been achieved through ART, there is still potential for increasing the success rates. As a result, there is a need to create optimum conditions in order to increase ART efficacy. The selection of the best sperm, oocyte, and embryo, as well as the achievement of optimal endometrial receptivity, through the contribution of new diagnostic and treatment methods, based on a personalized proteomic approach, may assist in the attainment of this goal. Proteomics represent a powerful new technological development, which seeks for protein biomarkers in human tissues. These biomarkers may aid to predict the outcome, prevent failure, and monitor in a personalized manner in vitro fertilization (IVF) cycles. In this review, we will present data from studies that have been conducted in the search for such biomarkers in order to identify proteins related to good sperm, oocyte, and embryo quality, as well as optimal endometrial receptivity, which may later lead to greater results and the desirable ART outcome.
Implementing a system architecture model for automated aircraft cabin assembly processes
Authors: Markusheska Nastasija , Srinivasan Venkatachalam , Walther Jan-Niclas , Gindorf Alex , Biedermann Jörn , Meller Frank , Nagel Björn 
Published: May 2022

AbstractAircraft manufacturers provide their customers with a number of options for aircraft customization, including a wide variety of pre-qualified optional equipment from which they can select different components according to their requirements. The numerous options cover a variety of engines, navigation systems, and interior cabin designs. This flexibility gives the possibility to the airlines to differentiate their brands. Moreover, a unique cabin interior design leaves an enduring impression on their customers and constitutes their expectations for the upcoming flight. On the other hand, many choices result in many different specifications, long delivery periods, complicated installation procedures such as stopping the running assembly of the cabin, disassembling already installed cabin components, and assembling new cabin models. Therefore, aircraft customization increases the cost and the lead time of the aircraft manufacturing processes and thus decreases the production rates. It is in the best interest of aircraft manufacturers and airlines to automate and optimize the customization processes to make them more time and cost efficient. This paper presents a method for establishing reconfigurable and optimized scheduling for aircraft cabin assembly. The data necessary for calculating the optimal schedule are retrieved from cabin system architecture that is built with semantic web language. The focus is on building a system architecture ontology model for automated scheduling of assembly processes of an aircraft cabin, which opens up the possibility for cabin customization at every assembly step. Moreover, the cabin ontology can be used as a foundation for co-design where each expert of their branch can further upgrade the model. With the algorithm presented in this paper, the ontology can be upgraded with new data, which will automatically correlate with the existing data in the cabin ontology. The knowledge-based ontology model provides a view of the whole chain from design to realization and feedback links to all included parties. Moreover, it gives the possibility for agile changes in the assembly sequence in response to the updated demands of the clients.
Lineability, spaceability, and latticeability of subsets of C([0, 1]) and Sobolev spaces
Authors: Carmona Tapia J. , Fernández-Sánchez J. , Seoane-Sepúlveda J. B. , Trutschnig W. 
Published: May 2022

AbstractThis work is a contribution to the ongoing search for algebraic structures within a nonlinear setting. Here, we shall focus on the study of lineability of subsets of continuous functions on the one hand and within the setting of Sobolev spaces on the other (which represents a novelty in the area of research).
Non-isothermal two-phase flow in deformable porous media: systematic open-source implementation and verification procedure
Authors: Grunwald Norbert , Lehmann Christoph , Maßmann Jobst , Naumov Dmitri , Kolditz Olaf , Nagel Thomas 
Published: May 2022

Abstract
We propose a formulation for non-isothermal two-component two-phase flow through deformable porous media. The approach covers phase transitions among both phases, i.e. liquid phase components evaporate into the gas phase while gas phase components dissolve or condensate into the liquid phase. These phase transitions always take place in thermodynamic equilibrium. The set of model equations is thereby largely independent of the specific constitutive relations. Starting from general equilibrium equations, we show the evolution of the system of weak formulations of all governing equations, which are then discretised with Taylor-Hood elements in a standard finite element approach. The model equations and the construction of the constitutive equilibria are implemented in the open-source simulator OpenGeoSys, which can be freely used and modified. To verify the implementation, we have selected a number of complementary test cases covering a wide range of process couplings. The numerical model is compared with analytical and semi-analytical solutions of these problems as well as with experimental results. It is shown in the paper that by including thermodynamic effects, solid mechanics, and phase transition processes, the proposed numerical model covers many characteristic features of unsaturated geomaterials and can be employed for the description of a broad range of problems encountered in geotechnical engineering.

Article highlights

An open-source FEM tool for non-isothermal two-phase flow in deformable porous or fractured media is presented in detail.

The model features phase transitions across both fluid phases based on simple equilibrium conditions.

A variety of benchmark tests is presented and compared to other software results and to exact solutions.
Deviant Cartographies: A Contribution to Post-critical Cartography
Authors: Edler Dennis , Kühne Olaf 
Published: May 2022

AbstractBased on the recently developed approach of 'post-critical cartography', this article addresses how developments in cartography can be interpreted functionally, dysfunctionally, afunctionally, and metafunctionally. This interpretation takes up the sociological topic ofdeviance. Normatively, this article bases on Ralf Dahrendorf’s concept of life chances. It includes established terminology which can be applied to the development of cartography. For example, the development and dissemination of digital cartography, in different development stages, has shown to be functional. Cartographic representations restricting life chances due to disinformation and manipulation can be described as dysfunctional. Cartographic representations that do not receive positive responses from the public or the professional community can be characterized as afunctional. Metafunctional representations are capable of highlighting the contingency of the world and its cartographic interpretation, particularly by including the stylistic device of irony. Critical cartography has made some functional contributions to cartography, but it also comprises dysfunctional effects originating in its moral rigorism. This article intends to contribute to the preservation of its functional and to overcome its dysfunctional impacts.