bluuebunny/crossref_metadata_2025_split huggingface dataset:
A universal cell‐free DNA approach for response prediction to preoperative chemoradiation in rectal cancer
Authors: Grinshpun Albert , Kustanovich Anatoli , Neiman Daniel , Lehmann‐Werman Roni , Zick Aviad , Meir Karen , Vainer Elez , Granit Roy Z. , Arad Amit , Daskal Noa , Schwartz Ruth , Sapir Eli , Maoz Myriam , Tahover Esther , Moss Joshua , Ben‐Dov Iddo Z. , Peretz Tamar , Hubert Ayala , Shemer Ruth , Dor Yuval 
Published: December 2022

AbstractThe standard treatment approach for stage II/III rectal cancer is neoadjuvant chemoradiation therapy (nCRT) followed by surgery. In recent years, new treatment approaches have led to higher rates of complete tumor eradication combined with organ‐preservation strategies. However, better tools are still needed to personalize therapy for the individual patient. In this prospective observational study, we analyzed colon‐derived cell‐free (cf)DNA (c‐cfDNA) using a tissue‐specific DNA methylation signature, and its association with therapy outcomes. Analyzing plasma samples (n = 303) collected during nCRT from 37 patients with locally advanced rectal cancer (LARC), we identified colon‐specific methylation markers that discriminated healthy individuals from patients with untreated LARC (area under the curve, 0.81; 95% confidence interval, 0.70‐0.92; P < .0001). Baseline c‐cfDNA predicted tumor response, with increased levels linked to larger residual cancer. c‐cfDNA measured after the first week of therapy identified patients with maximal response and complete cancer eradication, who had significantly lower c‐cfDNA compared with those who had residual disease (8.6 vs 57.7 average copies/ml, respectively; P = .013). Increased c‐cfDNA after 1 week of therapy was also associated with disease recurrence. Methylation‐based liquid biopsy can predict nCRT outcomes and facilitate patient selection for escalation and de‐escalation strategies.
Trends and progress in studying butterfly migration
Authors: Chowdhury Shawan , Zalucki Myron P. , Amano Tatsuya , Poch Tomas J. , Lin Mu‐Ming , Ohwaki Atsushi , Lin Da‐Li , Yang Li , Choi Sei‐Woong , Jennions Michael D. , Fuller Richard A. 
Published: December 2022

AbstractSeveral hundred butterfly species show some form of migratory behaviour. Here we identify how the methodologies available for studying butterfly migration have changed over time, and document geographic and taxonomic foci in the study of butterfly migration. We review publications on butterfly migration published in six languages (English, Simplified Chinese, Traditional Chinese, Japanese, Korean, and Spanish), summarise how migration in butterflies has been studied, explore geographic and taxonomic patterns in the knowledge base, and outline key future research directions. Using English search keywords, we found only 58 studies from Asia; however, after searching in local languages, we found an additional 98 relevant studies. Overall, butterfly migration studies are mostly from North America and Europe. Most studies focus on three species: monarch (Danaus plexippus), painted lady (Vanessa cardui) and red admiral (Vanessa atalanta). About 62% of publications are focused on the monarch, with nearly 50% of migratory butterfly species mentioned in only a single paper. Several research methods have been applied to ascribe migratory status and to study the physiology, neurobiology, and ecology of migration; however, virtually all this research is on a handful of species. There remain hundreds of species for which we do not understand the comprehensive seasonal pattern of movement, flight destinations, wintering, or breeding grounds. A better understanding of movement ecology and migratory connectivity is needed to effectively conserve migratory butterflies. It is essential that research becomes more geographically and linguistically representative since migrants frequently cross political borders and international cooperation is necessary for their conservation.
Eukaryotic initiation factor 6 repression mitigates atherosclerosis progression by inhibiting macrophages expressing Fasn
Authors: Chen Yang , Wang Zhenzhen , Xian Xuemei , Zhuang Yun , Chang Jiajia , Zhan Xiaoqiang , Han Xufeng , Chen Quangang , Yang Zhangping , Chen Renjin 
Published: December 2022

AbstractAtherosclerosis, a chronic inflammatory disease that often leads to myocardial infarction and stroke, is mainly caused by lipid accumulation. Eukaryotic initiation factor 6 (Eif6) is a rate‐limiting factor in protein translation of transcription factors necessary for lipogenesis. To determine whetherEif6affects atherosclerosis,Eif6+/− mice were crossed intoApoe−/−background.Apoe−/−/Eif6+/−mice on high fat diet showed significant reduction in atherosclerotic lesions and necrotic core content in aortic root sections in comparison withApoe−/−mice. RNA‐Seq was used to investigate the effect of Eif6 in aorta. Deficiency of Eif6 shows broad effect on cell metabolism. Expression of genes for fatty acid synthesis including Fatty acid synthase (Fasn),Elovl3,Elovl6andAcacaare down‐regulated in aortas. Importantly, Fasn is decreased in macrophages. Results suggest that Eif6 deficiency may decrease atherosclerosis through inhibition of Fasn and lipids metabolism in macrophages.
Withdrawn: Therapeutic effect of N‐Acetyl‐Seryl‐Aspartyl‐Proline and vasoactive intestinal peptide on COPD pathophysiology
Authors: Yang Yanna , Zhang Ronghua , Zhu Wei , Yin Zongxiu 
Published: December 2022

The above article, published online on 5 December 2022, on Wiley Online Library (https://doi.org/10.1002/jbt.23057), has been withdrawn by agreement between the journal Editor in Chief, Hari Bhat, and Wiley Periodicals, LLC.The withdrawal has been agreed due to a technical error at the publisher that caused the article to be mistakenly published online although publication had been canceled because the authors did not approve their proof.
Antibiotic prophylaxis and its effect on postprocedural adverse events in endoscopic retrograde cholangiopancreatography for primary sclerosing cholangitis
Authors: Gustafsson Arvid , Enochsson Lars , Tingstedt Bobby , Olsson Greger 
Published: December 2022

AbstractBackground and AimPrimary sclerosing cholangitis (PSC) is characterized by multiple strictures of the biliary tree. Patients with PSC frequently require repeated endoscopic retrograde cholangiopancreatography (ERCP) procedures. These procedures are encumbered by an increased incidence of infectious adverse events such as cholangitis. Evidence regarding whether antibiotic prophylaxis (AP) should be administered is sparse; however, prophylaxis is recommended. We aimed to determine whether AP affects the rate of postprocedural infectious and overall adverse events.MethodsWe conducted a retrospective cohort study and extracted all ERCP procedures with indicated PSC performed between 1 January 2006 and 31 December 2019, which were registered in the Swedish Registry for Gallstone Surgery and ERCP (GallRiks). The exclusion criteria were incomplete 30‐day follow‐up, non‐index procedures, or ongoing antibiotics. The main outcomes were postprocedural infectious adverse events and overall adverse events at the 30‐day follow‐up.ResultsA total of 2144 procedures with indication of PSC were eligible for inclusion. AP was administered in 1407 (66%) of these procedures. Patients receiving AP were slightly younger (44 vs 46 years, P = 0.005) and had more comorbidities (ASA ≥3, 19.8% vs 13.6%; P  < 0.001). Procedures with AP demonstrated an infectious adverse event rate of 3.3% compared to 4.5% for non‐AP procedures (P = 0.19). Postprocedural infectious adverse events (odds ratio [OR] 0.76, 95% confidence interval [CI] 0.48–1.21) and overall adverse events (OR 0.79, 95% CI 0.60–1.04) did not differ between AP and non‐AP.ConclusionPatients with PSC who undergo ERCP have the same frequency of adverse events regardless of whether AP was used.
Recessions and recoveries in Central African countries: Lessons from the past
Authors: Djoukouo Any Flore Djoumessi 
Published: December 2022

AbstractThe Great Financial Crisis and the COVID‐19 pandemic have raised concerns about business cycles. In this paper, we examine the dynamics of past business cycles in CAEMC economies to infer the shapes of recessions and subsequent recoveries. We use annual GDP data covering the period 1960–2020 and non‐parametric approach. The main results are fourfold. First, recessions are, on average, long with a positive duration dependence relationship and the strength of recoveries is independent of the duration and the depth of the associated recessions. Second, recessions and recoveries are not all alike, meaning that history cannot be used as a guide for forecasting issue. Third, nearly 45% of the recessions and subsequent recoveries are V‐shaped, and the L, U and W patterns appear when governments are heavily indebted. Fourth, a regional cycle sometimes emerges. The results suggest a strengthening of the capacities of CAEMC states and a resilient supply chain management.
Particulate matter exposure and chronic cerebral hypoperfusion promote oxidative stress and induce neuronal and oligodendrocyte apoptosis in male mice
Authors: Lamorie‐Foote Krista , Liu Qinghai , Shkirkova Kristina , Ge Brandon , He Shannon , Morgan Todd E. , Mack Wendy J. , Sioutas Constantinos , Finch Caleb E. , Mack William J. 
Published: December 2022

AbstractChronic cerebral hypoperfusion (CCH) may amplify the neurotoxicity of nanoscale particulate matter (nPM), resulting in white matter injury. This study characterized the joint effects of nPM (diameter ≤ 200 nm) and CCH secondary to bilateral carotid artery stenosis (BCAS) exposure on neuronal and white matter injury in a murine model. nPM was collected near a highway and re‐aerosolized for exposure. Ten‐week‐old C57BL/6 male mice were randomized into four groups: filtered air (FA), nPM, FA + BCAS, and nPM + BCAS. Mice were exposed to FA or nPM for 10 weeks. BCAS surgeries were performed. Markers of inflammation, oxidative stress, and apoptosis were examined. nPM + BCAS exposure increased brain hemisphere TNFα protein compared to FA. iNOS and HNE immunofluorescence were increased in the corpus callosum and cerebral cortex of nPM + BCAS mice compared to FA. While nPM exposure alone did not decrease cortical neuronal cell count, nPM decreased corpus callosum oligodendrocyte cell count. nPM exposure decreased mature oligodendrocyte cell count and increased oligodendrocyte precursor cell count in the corpus callosum. nPM + BCAS mice exhibited a 200% increase in cortical neuronal TUNEL staining and a 700% increase in corpus callosum oligodendrocyte TUNEL staining compared to FA. There was a supra‐additive interaction between nPM and BCAS on cortical neuronal TUNEL staining (2.6× the additive effects of nPM + BCAS). nPM + BCAS exposure increased apoptosis, neuroinflammation, and oxidative stress in the cerebral cortex and corpus callosum. nPM + BCAS exposure increased neuronal apoptosis above the separate responses to each exposure. However, oligodendrocytes in the corpus callosum demonstrated a greater susceptibility to the combined neurotoxic effects of nPM + BCAS exposure.
Daily precipitation and temperature for 2021–2050 over China: Multiple RCMs and emission scenarios corrected by a trend‐preserving method
Authors: Zhang Jingpeng , Peng Shouzhang , Wang Zhengshi , Fu Jinxia , Li Zhi 
Published: December 2022

AbstractDaily climate data are extremely important to drive ecological models, but the outputs of climate models are often deviated from the observations. The bias correction methods mostly highlight the target statistical parameters (e.g., mean and variance) for a target period, but perturb the simulated change trend and variability. In this study, we utilize a trend‐preserving bias correction method that can simultaneously consider the frequency and intensity of climatic variables to adjust the daily maximum and minimum temperature, and precipitation (Tmax, Tmin, and Pre) from CORDEX‐EA regional climate models for the period of 2021–2050 over China. Results show that: (a) the bias correction method greatly improves the spatial patterns of simulated Tmax, Tmin, and Pre since the corrected data has higher correlation and smaller differences across the whole domain. The differences in mean Tmax, Tmin, and Pre between climate models and observations have been reduced from −4.5 ± 6.41°C, −2.06 ± 0.58°C, 177.25 ± 51.55 mm before correction to 0.01 ± 0.02°C, −0.01 ± 0.02°C, −26.22 ± 6.39 mm after correction, respectively. In addition, the simulated change trend and climate variability at all time scales are well preserved. (b) Spatially, the warming rates in the west would be higher than in the east, and they are larger under the most severe future emissions scenario (RCP8.5) relative to the low‐mid emissions scenario (RCP4.5). The Pre change would mainly occur over east China with the significant upward trend. The dataset presented in this article has been published in the Network Common Data Form (NetCDF) File Format at https://doi.org/10.5281/zenodo.5058620.
Case presentation and panel discussion: Micronutrient therapy in critical illness
Authors: Pimiento Jose M. , Rice Todd W. , Heyland Daren K. , Stoppe Christian , Katz Jennifer , Morrison Chet , Mechanick Jeffrey I. , Patel Jayshil J. 
Published: December 2022

AbstractOver the past decade, the use of supraphysiologic doses of micronutrients (also called metabolic resuscitation) in critically ill patients has gained significant attention. Building upon preclinical and observational human data, numerous randomized controlled trials have tested the impact of multiple micronutrients on various outcomes in critically ill patients. At the 2022 American Society for Parenteral and Enteral Nutrition Preconference Course, three world‐renowned speakers delivered talks on the (1) overall role of micronutrients and, specifically, (2) selenium and vitamin C and (3) vitamin D and zinc in critically ill patients. Here, the case presentation and discussion from the postsession question and answer period are presented. The moderator for this session was Jose Pimiento, MD, and the speakers and panelists were Christian Stoppe, MD, Todd Rice, MD, and Daren Heyland, MD.
Case presentation and panel discussion: Transitions in care
Authors: Katz Jennifer , Mercer David F. , Schuetz Philipp , Mundi Manpreet S. , Pimiento Jose , Morrison Chet , Mechanick Jeffrey I. , Patel Jayshil J. 
Published: December 2022

AbstractThere is evidence that significant quality problems arise as patients transitions in care from one setting to another. Attention to nutrition during transitions of care is important to avoid complication. During the American Society for Parenteral and Enteral Nutrition 2022 preconference course, nutrition during transition of care from pediatric to adult care, from the intensive care unit to the hospital floors and from the hospital to home was addressed.
Influence of insurance status on the postoperative outcomes of cytoreductive surgery and HIPEC
Authors: Kubi Boateng , Nudotor Richard , Fackche Nadege , Rowe Julian , Cloyd Jordan M. , Ahmed Ahmed , Grotz Travis E. , Fournier Keith , Dineen Sean , Veerapong Jula , Baumgartner Joel M. , Clarke Callisia , Patel Sameer H. , Dhar Vikrom , Lambert Laura , Abbott Daniel E. , Pokrzywa Courtney , Raoof Mustafa , Lee Byrne , Zaidi Mohammad Y. , Maithel Shishir K. , Johnston Fabian M. , Greer Jonathan B. 
Published: December 2022

AbstractBackgroundCytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is increasingly performed for peritoneal surface malignancies but remains associated with significant morbidity. Scant research is available regarding the impact of insurance status on postoperative outcomes.MethodsPatients undergoing CRS/HIPEC between 2000 and 2017 at 12 participating sites in the US HIPEC Collaborative were identified. Univariate and multivariate analyses were used to compare the baseline characteristics, operative variables, and postoperative outcomes of patients with government, private, or no insurance.ResultsAmong 2268 patients, 699 (30.8%) had government insurance, 1453 (64.0%) had private, and 116 (5.1%) were uninsured. Patients with government insurance were older, more likely to be non‐white, and comorbid (p < 0.05). Patients with government (OR: 2.25, CI: 1.50−3.36, p < 0.001) and private (OR: 1.69, CI: 1.15−2.49, p = 0.008) insurance had an increased risk of complications on univariate analysis. There was no independent relationship on multivariate analysis. An American Society of Anesthesiologists score of 3 or 4, peritoneal carcinomatosis index score >15, completeness of cytoreduction score >1, and nonhome discharge were factors independently associated with a postoperative complication.ConclusionWhile there were differences in postoperative outcomes between the three insurance groups on univariate analysis, there was no independent association between insurance status and postoperative complications after CRS/HIPEC.
Posttraumatic stress disorder, diurnal cortisol, and ambulatory blood pressure in early and late pregnancy
Authors: Bublitz Margaret H. , Nillni Yael , Nugent Nicole R. , Sanapo Laura , Habr Naya , Bourjeily Ghada 
Published: December 2022

AbstractPosttraumatic stress disorder (PTSD) affects 1 in 20 reproductive‐aged women and is associated with cardiovascular disease morbidity and mortality. The pathophysiology linking PTSD to cardiovascular disease in nonpregnant adults is proposed to include hypothalamic and autonomic dysregulation; however, the pathways explaining this association in pregnancy are unclear. We examined diurnal cortisol and ambulatory blood pressure (BP) among 254 pregnant women at approximately 12 and 32 gestational weeks. Participants were, on average, 31 years old (SD = 5), 24.4% reported their ethnicity as Hispanic, and 62.2% reported their race as White. PTSD symptoms were measured using the PTSD Checklist for DSM‐5 (PCL‐5). Hierarchical linear regression analyses were performed to examine associations pregnancy between PTSD and cortisol at awakening, 30 min after awakening, and bedtime in early and late pregnancy, as well as associations between PTSD symptoms and daytime and nighttime systolic (SBP) and diastolic BP (DBP) and BP variability. Logistic regression analyses were conducted to test associations between PTSD symptoms and BP dipping. The results showed a positive association between PTSD symptoms and nighttime BP and BP variability at 32 gestational weeks, ∆R2 = .036–.067. PTSD symptoms were negatively associated with awakening cortisol at 12 gestational weeks in unadjusted models. These findings contribute to understanding the associations between PTSD and adverse cardiovascular conditions in pregnancy. More research is needed to replicate these findings and examine whether PTSD interventions are effective at modifying pathways and decreasing the risk for cardiovascular complications in pregnancy.
Impact of partial surface waviness on the tribological performance of hydrodynamic journal bearing
Authors: Bangotra Arun , Sharma Sanjay 
Published: December 2022

AbstractIn this paper, the static performance analysis of journal bearing having full and partial surface waviness has been presented. The surface waviness is to be considered in the full, first half, second half, and pressure‐increasing and decreasing regions of the bearing for analysis. The effect of surface waviness is considered by modifying the lubricant flow governing Reynolds equation with the film thickness equation and it is solved with the finite element method to get performance parameters like bearing load capacity, friction coefficient, and so forth operating under eccentricity ratios range of 0.2–0.8. The waviness geometrical parameters like waviness numbers and amplitudes are also considered in circumferential, axial, and both directions in the selected regions. The maximum performance has been found for waviness in the full and pressure‐increasing region in the circumferential direction at a high eccentricity ratio.
Radial symmetry and partially overdetermined problems in a convex cone
Authors: Lee Jihye , Seo Keomkyo 
Published: December 2022

AbstractWe obtain the radial symmetry of the solution to a partially overdetermined boundary value problem in a convex cone in space forms by using the maximum principle for a suitable subharmonic function P and integral identities. In dimension 2, we prove Serrin‐type results for partially overdetermined problems outside a convex cone. Furthermore, we obtain a Rellich identity for an eigenvalue problem with mixed boundary conditions in a cone.
Dysbiosis of gut microbiome contributes to glaucoma pathogenesis
Authors: Chen Shida , Wang Yayi , Liu Yaoming , Li Fei , Chen Yang , Fang Xiuli , Wen Tao , Xu Shuyi , Kermany Daniel , Deng Shufang , Li Gen , Zhang Kang , Zhang Xiulan 
Published: December 2022

AbstractMicrobiome dysfunction is considered to contribute to the pathogenesis of many neurodegenerative diseases. However, the relationship between the gut microbiome and glaucoma, a neurodegenerative disorder remains largely unknown. Here, we identified that the gut microbiome of glaucoma patients were rich in Dysgonamonadaceae, along with a lower level of Barnesiellaceae by metagenomic sequencing. This microbiome pattern is shown to increased the production of short chain fatty acids (SCFAs) in the fecal and blood samples. Reducing these glaucoma‐specific gut microbiome bacteria significantly reduced retinal ganglion cell (RGC) loss by alleviating the activation of retinal microglia cells and overproduction of inflammatory cytokines in acute glaucoma mouse model, whereas SCFAs treatment aggravated microglia activation. Mechanistically, reducing the glaucoma‐specific gut microbiome bacteria decreased the retinal microRNA profile including MiR‐122‐5p, which led to neuroprotection through inhibition of retinal inflammation. We validated our results by showing that fecal microbiome transplantation from glaucoma patients significantly exacerbated retinal microglia activation and increased retinal inflammation. Our findings indicate that the change of gut microbiome is associated with glaucoma, by activation of retinal microglia and changing expression of retinal microRNAs, leading to retinal inflammation reaction and RGC loss. The gut microbiome may be a new target for the neuroprotection in glaucoma.