bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of hydrogeological conditions of a fractured shale aquifer in Yala Area (SE Nigeria) characterized by saline groundwater
Authors: Edet Aniekan , Okereke Chiedu 
Published: July 2022

AbstractGeological, hydrogeological and geophysical investigations were carried out in Yala Area (SE Nigeria) to delineate potential zones for future groundwater development. The area is underlain by Turonian fractured shale rock intruded by basaltic rocks and saline water. High lineament density (> 30 km−1) recorded in the north suggest high permeable zone, compared with low lineament density (< 10 km−1) in the south and east. Geophysical results reveal four types of aquifers: an upper weathered, fractured shale aquifer with mean resistivity and thickness in the range 27–40 Ω m and 20–28 m and a lower fractured shale aquifer with mean resistivity in the range 28.5 to 36.0 Ω m and unresolved thickness; fractured saline shale aquifer with mean resistivity and thickness of 21 Ω m and 50 m; fractured silty shale aquifer with mean resistivity and thickness of 54.4 Ω m and 10 m and basaltic intrusive fractured shale aquifer with mean resistivity and thickness of 135.6 Ω m and 6 m. A broad range of aquifer parameters were obtained from resistivity data and pumping test. Groundwater quality on the mean indicated alkaline and good fresh water for drinking and irrigation use with minor level of salinization. Concentration of dissolved ions in the area are enhanced through weathering and ion exchange. On the basis of these data, the potential zones for groundwater harnessing have been delineated in Yala Area.
Tomb S181 in Cyrene and its Doric false peristyle
Authors: Cherstich Luca 
Published: July 2022

AbstractSituated on the westernmost corner of the Southern Necropolis, Tomb S181 is an important rock-cut monument, unlike any other thus far known in Cyrene. The presence of a Doric false peristyle running all around the chamber is unique in the context of the Cyrenean funerary culture, as it seems to elaborate and modify the model of the Internal Doric Frieze (seen in famous tombs of the near-by Western Necropolis) in a new, previously unpublished solution. Tomb S181 casts further light on the complicated relationship with the Alexandrian funerary world. This paper describes the tomb and considers it from multiple and different points of view: traditional art-historical comparisons are sought in order to cast light on the chronology but, on the other hand, the display strategies are also analyzed to reconstruct the importance of this monument for the Cyrenean monumental funerary tradition. Tomb S181 is certainly a hybrid entity, the product of a local culture accepting but also deeply modifying Alexandrian influences in terms of architecture and, possibly, also of funerary ritual behaviours. Tomb S181 clearly attests the vitality of rock-cut funerary architecture in Cyrene during the Hellenistic period.
How do elderly people with malnutrition and their families perceive collaborative practice in primary care? A phenomenological study
Authors: Mawardi Fitriana , Lestari Ayuningtyas Satya , Onishi Hirotaka , Sasongko Elsa Pudji Setiawati , Kusnanto Hari , Hilmanto Dany 
Published: July 2022

AbstractAs a frequent and serious problem in elderly people, malnutrition is a complex health issue. It requires comprehensive care through interprofessional collaborative practice (IPCP) engaging five health professionals in primary care consisting of a physician, dentist, nurse, dietitian and pharmacist. In Indonesia, the usual care involves monthly health screening in community programmes named Posyandu. The current study aimed to explore perceptions of elderly people with malnutrition and their families’ experiences with interprofessional teams compared with usual care in primary care. This qualitative study used the phenomenological approach based on Creswell. Interviews were conducted with fourteen elderly people and their families in the intervention group and fourteen elderly people with their families in the control group. Data were analysed using the four steps of descriptive qualitative analysis described by Giorgi, including comparing the experiences of both groups. Elderly people with malnutrition in the intervention group had more valued experiences regarding two-way communication with the IPCP team and felt it involved more comprehensive care for malnutrition management. Participants in the control group experienced communication between the health care providers and elderly people; however, it was not clear enough. There were overlapping roles among health care providers in the usual care. However, both groups shared the experience that family members are partners in nutritional management. Elderly people and their families in the intervention group have more valuable experiences related to two-way communication and comprehensive care. Family as partners was experienced in both the intervention and control groups.
Management of paediatric laryngotracheal trauma
Authors: Li H , Li Z , Zhao J , Wang G , Wang H , Zhang F , Sun N , Han Y , Zhang J , Ni X 
Published: July 2022

AbstractObjectiveTo summarise and describe the clinical presentations, diagnostic approaches and airway management techniques in children with laryngotracheal trauma.MethodsThe clinical data related to laryngotracheal trauma diagnosed and treated at the Beijing Children's Hospital, between January 2013 and July 2018, were retrospectively reviewed. Disease diagnosis, treatment, management and outcomes were analysed.ResultsA total of 13 cases were enrolled, including 7 cases of penetrating laryngotracheal trauma. The six cases of blunt laryngotracheal trauma were caused by collisions with hard objects. In all cases, voice, airway and swallowing outcomes were graded as ‘good’, except for one patient who had residual paralysis of the vocal folds.ConclusionFlexible fibre-optic laryngoscopy and computed tomography can play an important role in diagnosing laryngotracheal trauma. The airway should be secured and, if necessary, opened by tracheal intubation or tracheostomy.
Redefining Health Technology Assessment: A Comment on “The New Definition of Health Technology Assessment: A Milestone in International Collaboration”
Authors: Culyer Anthony , Husereau Don 
Published: July 2022

AbstractA new definition of health technology assessment (HTA), developed by an International Joint Task Group claims to be a “milestone,” “an historic achievement,” and “a cornerstone reference”—claims that we think to be unjustified. We too favor clear definitions, especially when confusion abounds. However, the Task Group seems to have developed a definition without the help of usual conventions regarding definitions and, in our view, through an ill-described process. A definition ought to differentiate the entity defined from other entities. This one fails to do so. It states traits that are true of HTA (e.g., that is interdisciplinary) but HTA is not alone in this. There are other concerns: examples of HTA’s use are embodied in the definition, precluding other uses; the adjectives used, although generally true of HTA, are not differentiating features; and attributing to HTA specific purposes, thereby excluding other purposes. We have sympathy for these purposes but cannot consider them HTA’sonlypurposes or even, itsmainpurpose. A newcomer to HTA, on reading this definition, will have no idea of HTA’s true potential. These numerous failings, we feel, send all the wrong signals, and could ultimately weaken, rather than strengthen perceptions of HTA’s legitimacy and objectivity. The production of a good definition remains, therefore, a work in progress.
For Profit or Patriotism? Balancing the Interests of the Chinese State, Host Country and Firm in the Lao Rubber Sector
Authors: Lu Juliet 
Published: July 2022

AbstractChinese state firms are expected not only to profit but also to serve state interests. But the Chinese state is fragmented: border provinces are taking on an expanded role in China's global expansion and a broad range of firm activities could be defined as patriotic contributions. Through the case of Yunnan State Farms (YSF), a province-level state-owned enterprise, this article explores how state firms interpret and navigate multiple state interests while also pursuing profit. The firm's ability to profit depends on balancing the demands and support of different Chinese state actors while depicting itself as a development partner to the Lao state and a contributor to Sino-Lao diplomatic relations and border region stability. This case thus shows that, instead of YSF's behaviour being directed by the state, the firm exercises considerable latitude in defining its contributions to state interests through the expansion of rubber production as a driver of development.
Efficacy of avapritinib versus best available therapy in the treatment of advanced systemic mastocytosis
Authors: Reiter Andreas , Gotlib Jason , Álvarez-Twose Iván , Radia Deepti H. , Lübke Johannes , Bobbili Priyanka J. , Wang Aolin , Norregaard Chelsea , Dimitrijevic Saša , Sullivan Erin , Louie-Gao Melinda , Schwaab Juliana , Galinsky Ilene A. , Perkins Cecelia , Sperr Wolfgang R. , Sriskandarajah Priya , Chin Andi , Sendhil Selvam R. , Duh Mei Sheng , Valent Peter , DeAngelo Daniel J. 
Published: July 2022

AbstractAdvanced systemic mastocytosis (AdvSM) is a rare myeloid neoplasm associated with poor overall survival (OS). This study (NCT04695431) compared clinical outcomes between patients with AdvSM treated with avapritinib in the Phase 1 EXPLORER (NCT0256198) and Phase 2 PATHFINDER (NCT03580655) trials (N = 176) and patients treated with best available therapy (BAT; N = 141). A multi-center, observational, retrospective chart review study was conducted at six study sites (four European, two American) to collect data from patients with AdvSM who received BAT; these data were pooled with data from EXPLORER and PATHFINDER. Comparisons between outcomes of OS, duration of treatment (DOT), and maximum reduction in serum tryptase were conducted between the treatment cohorts, with adjustment for key covariates. The results indicated that the avapritinib cohort had significantly better survival (adjusted hazard ratio (HR) (95% confidence interval (CI)): 0.48 (0.29, 0.79); p = 0.004) and significantly longer DOT (HR: 0.36 (0.26, 0.51); p < 0.001) compared to the BAT cohort. Additionally, the mean difference in percentage maximum reduction in serum tryptase levels was 60.3% greater in the avapritinib cohort (95% CI: −72.8, −47.9; p < 0.001). With no randomized controlled trials comparing avapritinib to BAT, these data offer crucial insights into the improved efficacy of avapritinib for the treatment of AdvSM.
Quantitative phase imaging through an ultra-thin lensless fiber endoscope
Authors: Sun Jiawei , Wu Jiachen , Wu Song , Goswami Ruchi , Girardo Salvatore , Cao Liangcai , Guck Jochen , Koukourakis Nektarios , Czarske Juergen W. 
Published: July 2022

AbstractQuantitative phase imaging (QPI) is a label-free technique providing both morphology and quantitative biophysical information in biomedicine. However, applying such a powerful technique to in vivo pathological diagnosis remains challenging. Multi-core fiber bundles (MCFs) enable ultra-thin probes for in vivo imaging, but current MCF imaging techniques are limited to amplitude imaging modalities. We demonstrate a computational lensless microendoscope that uses an ultra-thin bare MCF to perform quantitative phase imaging with microscale lateral resolution and nanoscale axial sensitivity of the optical path length. The incident complex light field at the measurement side is precisely reconstructed from the far-field speckle pattern at the detection side, enabling digital refocusing in a multi-layer sample without any mechanical movement. The accuracy of the quantitative phase reconstruction is validated by imaging the phase target and hydrogel beads through the MCF. With the proposed imaging modality, three-dimensional imaging of human cancer cells is achieved through the ultra-thin fiber endoscope, promising widespread clinical applications.
Pharmacological treatment strategies for antipsychotic-induced hyperprolactinemia: a systematic review and network meta-analysis
Authors: Lu Zhe , Sun Yaoyao , Zhang Yuyanan , Chen Yu , Guo Liangkun , Liao Yundan , Kang Zhewei , Feng Xiaoyang , Yue Weihua 
Published: July 2022

AbstractAntipsychotic-induced hyperprolactinemia (AP-induced HPRL) occurs overall in up to 70% of patients with schizophrenia, which is associated with hypogonadism and sexual dysfunction. We summarized the latest evidence for the benefits of prolactin-lowering drugs. We performed network meta-analyses to summarize the evidence and applied Grading of Recommendations Assessment, Development, and Evaluation frameworks (GRADE) to rate the certainty of evidence, categorize interventions, and present the findings. The search identified 3,022 citations, 31 studies of which with 1999 participants were included in network meta-analysis. All options were not significantly better than placebo among patients with prolactin (PRL) less than 50 ng/ml. However, adjunctive aripiprazole (ARI) (5 mg: MD = −64.26, 95% CI = −87.00 to −41.37; 10 mg: MD = −59.81, 95% CI = −90.10 to −29.76; more than 10 mg: MD = −68.01, 95% CI = −97.12 to −39.72), switching to ARI in titration (MD = −74.80, 95% CI = −134.22 to −15.99) and adjunctive vitamin B6 (MD = −91.84, 95% CI = −165.31 to −17.74) were associated with significant decrease in AP-induced PRL among patients with PRL more than 50 ng/ml with moderated (adjunctive vitamin B6) to high (adjunctive ARI) certainty of evidence. Pharmacological treatment strategies for AP-induced HPRL depends on initial PRL level. No effective strategy was found for patients with AP-induced HPRL less than 50 ng/ml, while adjunctive ARI, switching to ARI in titration and adjunctive high-dose vitamin B6 showed better PRL decrease effect on AP-induced HPRL more than 50 ng/ml.
Targeting mitochondrial one-carbon enzyme MTHFD2 together with pemetrexed confers therapeutic advantages in lung adenocarcinoma
Authors: Mo Juanfen , Gao Zhenzhen , Zheng Li , Yan Miaolong , Xue Min , Xu Jianqiu , Bao Yi , Wu Jiayuan 
Published: July 2022

AbstractMetabolic remodeling is the fundamental molecular feature of malignant tumors. Cancer cells require sufficient energy supplies supporting their high proliferative rate. MTHFD2, a mitochondrial one-carbon metabolic enzyme, is dysregulated in several malignancies and may serve as a promising therapeutic candidate in cancer treatment. Here, our data confirmed that MTHFD2 gene and protein was upregulated in the cancerous tissues of LUAD patients and was correlated with a poor survival in LUAD. MTHFD2 was involved in lung cancer cell proliferation, migration, and apoptosis by mediating its downstream molecules, such as DNA helicases (MCM4 and MCM7), as well as ZEB1, Vimentin and SNAI1, which contributed to tumor cell growth and epithelial-to-mesenchymal transition (EMT) process. Moreover, we identified that miRNA-99a-3p appeared to be an upstream mediator directly regulating MTHFD2 and MCM4 expression. Moreover, specific inhibition of MTHFD2 functions by siRNA or a chemical compound, improved anti-tumor sensitivities induced by pemetrexed in LUAD. Taken together, our study revealed the underlying molecular mechanisms of MTHFD2 in regulating cell proliferation and identified a novel therapeutic strategy improving the treatment efficacies in LUAD.
Box C/D snoRNA SNORD89 influences the occurrence and development of endometrial cancer through 2’-O-methylation modification of Bim
Authors: Bao Hai-juan , Chen Xi , Liu Xin , Wu Wu , Li Qian-hui , Xian Jing-yuan , Zhao Yang , Chen Shuo 
Published: July 2022

AbstractThe small nucleolar RNA (snoRNA) is a type of small non-coding RNA widely distributed in the nucleoli of eukaryotic cells, promoting cancer development. The aim of this study was to assess box C/D snoRNA 89 (SNORD89) dysregulations in endometrial cancer. According to the TCGA database as well as the International Federation of Gynecology and Obstetrics (FIGO), higher SNORD89 expression is found in endometrial cancer tissues. In addition, the SNORD89 expression level was higher in endometrial carcinoma with lymph node metastasis than in endometrial carcinoma without lymph node metastasis. By interacting with the conservative chaperone protein methylase fibrillarin (Fbl), SNORD89 inhibits the translation process of the Bim gene, leading to a decrease in Bim protein. Cancer-promoting effect of SNORD89 can be reversed by Fbl knockdown or Bim overexpressing. What’s more, ASO-mediated silencing of SNORD89 could inhibit endometrial cancer cell proliferation and migration ability. Taken together, SNORD89 can modify Bim through 2′-O-methylation and affect downstream signaling pathways to promote endometrial cancer occurrence and development. The role of methylation modification in the prevention and treatment of endometrial cancer provides a new understanding and SNORD89 may be a new diagnostic and therapeutic target for endometrial cancer.
Older Korean men with inadequate vitamin D status have lower odds of radiologic osteoarthritis
Authors: Kim Seunghee , Lee Gun-Woo , Park Clara Y. 
Published: July 2022

AbstractMost studies on osteoarthritis (OA) and vitamin D status were performed in Whites with relatively adequate vitamin D status. Associations may differ by baseline 25-hydroxyvitamin D (25(OH)D) and race. We assessed the odds of OA and joint pain according to vitamin D status in Korean adults ≥ 50 years of age in the nationally representative Korea National Health and Nutrition Examination Survey (n = 8575). Agreement between radiologic OA (ROA) and self-reported OA were also assessed. Multivariate logistic regression was performed and participants were stratified by sex. Adults with serum 25(OH)D < 12 ng/mL and 12 to < 20 ng/mL had 26% and 18% lower odds of knee ROA, respectively, compared to those with 25(OH)D ≥ 20 ng/mL. Similar results were observed in men, but not women. No associations were found between 25(OH)D and knee ROA severity, lumbar spine ROA, symptomatic OA, or knee pain. Sensitivity of self-reported OA was low (27%), indicating a weak possibility of reverse causation. Prospective studies are required to identify the possible causality of vitamin D on OA in Korean men.
Outcomes of right-sided and left-sided colon cancer after curative resection
Authors: Yang Chien-Yi , Yen Min-Hsuan , Kiu Kee-Thai , Chen Yu-Ting , Chang Tung-Cheng 
Published: July 2022

AbstractThe right and left side of the colon derived from the midgut and hindgut, respectively. Previous studies have reported different characteristics of right-sided colon cancer (RCC) and left-sided colon cancer (LCC), but oncological outcomes remain unclear. This study compared the outcomes of RCC and LCC. This retrospective study included 1017 patients who received curative colectomy for stage I-III colon cancer at a single institute between August 2008 and December 2019. Overall survival (OS) and time to recurrence (TTR) were analyzed as outcome measurements. No significant difference in the OS or TTR of patients with RCC and LCC were observed. In subgroup analysis, RCC was associated with shorter TTR than LCC in stage II colon cancer (HR 2.36, 95% confidence interval 1.24–4.48, p < 0.01). Multivariate analysis demonstrated that right sidedness, R1 resection, low body mass index (BMI) and adjuvant chemotherapy were independent factors for poor prognosis for stage II colon cancer. Low BMI, perineural invasion, higher T stage and N2 stage were independent factors for poor prognosis for stage III colon cancer. The results were confirmed by multivariate analysis after propensity score matching. Our study revealed that RCC was an independent risk factor for recurrence in stage II colon cancer.
Voice Onset Time in Early- and Late-Stage Amyotrophic Lateral Sclerosis
Authors: Thomas Anusha , Teplansky Kristin J. , Wisler Alan , Heitzman Daragh , Austin Sara , Wang Jun 
Published: July 2022

Purpose:
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects bulbar functions including speech and voice. Voice onset time (VOT) was examined in speakers with ALS in early and late stages to explore the coordination of the articulatory and phonatory systems during speech production.

Method:

VOT was measured in nonword /bap/ produced by speakers with early-stage ALS (
n
= 11), late-stage ALS (
n
= 6), and healthy controls (
n
= 13), and compared with speech performance decline (a marker of disease progression) in ALS.

Results:

Overall comparison of the VOT values among the three groups showed a significant difference,
F
(2,27) = 11.71,
p
< .01. Speakers in late-stage ALS displayed longer voicing lead (negative VOT) than both healthy speakers and speakers in early-stage ALS. VOT was also significantly negatively correlated with speech performance (i.e., Intelligible Speaking Rate),
r
(15) = .74,
p
< .01.

Conclusions:
Speakers with more severe ALS showed greater occurrence of voicing lead and longer voicing lead. Findings show voicing precedes articulatory onset with disease progression in the production of bilabial stops, which suggests that the relative timing of coordination between the supralaryngeal structures and the phonatory system is affected in the late stage of ALS.
Speech-Language Pathologists' and Principals' Perceptions of Classroom-Based Services: Similar or Different?
Authors: Carlin Charles H. 
Published: July 2022

Purpose:
Administrative support and accurate perceptions are believed to facilitate the use of speech-language services that are integrated into the classroom (i.e., integrated classroom-based services [ICBS]). The purpose of this study was to compare elementary principals' and speech-language pathologists' (SLPs') perceptions of ICBS in three areas: (a) effectiveness and benefits, (b) impact of the SLP–teacher relationship, and (c) need for administrative support.

Method:
This study used a web-based survey to investigate Ohio elementary SLPs' and principals' perceptions of ICBS. Demographic information was collected, and participants were asked to state their level of agreement on 17 perception statements using a 5-point Likert scale. Two hundred and ten SLPs and 89 principals participated in the study.

Results:
Data showed that SLPs and principals held similar perceptions about the overall effectiveness of ICBS, the need for a positive SLP–teacher relationship, the importance of adequate administrative support, and several key benefits. Differences occurred on statements related to targeting speech goals, behavior management, student grouping, and data collection.

Conclusions:
SLPs and principals generally held more similar than different perceptions about ICBS. Where differences existed, it was recommended that SLPs work with principals to obtain professional development, implement caseload management strategies, and remove barriers that hinder the implementation of ICBS. The efforts may lead to the increased use of ICBS for elementary school–age children with speech-language impairments.