bluuebunny/crossref_metadata_2025_split huggingface dataset:
Методи адаптивного управління розвитком у забезпеченні умов інклюзивного середовища в закладі вищої освіти
Authors: Кравченко Ганна 
Published: December 2022

Аналіз досвіду педагогічних надбань теоретиків і практиків з питань організації освітнього процесу за інклюзивною формою навчання у закладах вищої освіти обґрунтовує значення використання методів адаптивного управління розвитком інклюзивного середовища.
Саме адаптивне управління розкриває закономірності організації освітнього процесу для студентів з особливими потребами, визначає сутність, зміст, форми та методи саме освітнього процесу, що визначає ефективність застосування методів адаптивного управління розвитком. Встановлено, що інклюзивне навчання передбачає створення освітнього середовища, яке відповідає потребам і можливостям кожної людини, незалежно від особливостей її психофізичного розвитку.
У змісті статті визначені основні здобутки інклюзивного освітнього середовища, важливі аспекти інклюзивної освіти, що забезпечують ефективність та якість навчання, застосування форм, методів та технологій, які враховують індивідуальні особливості осіб з особливими потребами. Звернено увагу на те, що навчання студентів з особливими потребами в закладах вищої освіти, з одного боку, допомагає їм позбутися почуття ізольованості, відчуження у суспільстві, сприяє зникненню соціальних бар’єрів, а з іншого – навчає студентів спілкуватися і співпрацювати разом. Освітнє середовище тільки тоді буде інклюзивним у ЗВО, коли буде спланований і організований фізичний простір, у якому студенти мають можливість безпечно пересуватися під час групових та індивідуальних занять; в академічних групах студентської молоді буде відбувається спілкування на позитивному психоемоційному рівні, що передбачає надання один одному допомоги; будуть створені умови спільної партнерської роботи студентів з особливими потребами та викладачами кафедр, які сприятимуть досягненню позитивного результату.
Виходячи з цього розкрито методи адаптивного управління розвитком інклюзивного середовища в закладах вищої освіти та подано їх характеристику. Зосереджено увагу на методах теоретичного та практичного рівнів адаптивного управління розвитком. Саме через визначення характерних ознак адаптивного управління запропоновано групи методів та власне методи адаптивного управління: загальні методи адаптивного управління спрямовані на підтримку існуючої системи інклюзивної освіти у напрямі її розвитку, а специфічні методи адаптивного управління щодо забезпечення умов інклюзивного середовища в закладах вищої освіти передбачають спеціальні дії.
Методика формування проєктувальної компетентності у майбутніх викладачів технічних дисциплін на засадах міждисциплінарного підходу
Authors: Коберляйн-Керлер Юрген 
Published: December 2022

В статті розглянуто методику формування проєктувальної компетентності у майбутніх викладачів технічних дисциплін на засадах міждисциплінарного підходу. Проаналізовані існуючі моделі формування проєктувальної компетентності у здобувачів педагогічної освіти, визначені їх структурні компоненти та змістовне наповнення. Узагальнена інформація стосовно структурних компонентів у всіх проаналізованих моделях формування проєктувальної компетентності. Докладно розглянуто кожен структурний компонент та його зміст на предмет подібності та відмінностей.
Розроблено модель методики формування проєктувальної компетентності у майбутніх викладачів технічних дисциплін на засадах міждисциплінарного підходу, обґрунтовано її структурні компоненти: цільовий, методологічний, змістовний, організаційно-діяльнісний та діагностичний. Спроєктовано зміст кожного структурного компоненту моделі.
Цільовий компонент моделі спроєктовано з урахуванням сучасного стану організації професійної освіти в Україні, особливостей діяльності педагогічних кадрів пов’язаних з проєктуванням освітнього процесу.
Методологічний компонент моделі спроєктовано з урахуванням компетентнісного та міждисциплінарного підходів.
Змістовний компонент моделі спроєктовано на підставі аналізу видів дидактичних проєктів та структури діяльності викладача технічних дисциплін щодо їх розробки.
Організаційно-діяльнісний компонент моделі спроєктовано у вигляді дидактичного інструментарію методики формування проєктувальної компетентності для проведення лекційних та практичних занять. Розроблено проєктні завдання трьох рівнів складності на підставі яких введено поняття рангу проєктувальної компетентності.
Діагностичний компонент моделі дозволив визначити критерії та показники сформованості проєктувальної компетентності. Введено рівні сформованості проєктувальної компетентності кожного рангу, які можна визначити за допомогою розроблених критеріїв та показників, що дає змогу зробити висновок про загальну сформованість проєктувальної компетентності.
Word-Of-Mouth Sebagai Sarana Pembentukan Intensi Generasi Muda dalam Berpartisipasi Pada Sektor Pertanian
Authors: Octaviana Dias Anugrah , Astini Ni Made , Susanto Bagus Aditya 
Published: December 2022

The agricultural sector is a vital sector for the survival of Indonesia. However, one of the problems faced is the regeneration of farmers because not all young people want to participate in this sector. One of the communities that responded to this condition is Aku Petani Indonesia. This community carries out various activities to create intention to participate in agriculture activities among the younger generation. This research is to study how these activities create word-of-mouth that can intention. The Theory of Planned Behavior is included as a theoretical framework. This research design is concurrent triangulation, which combines quantitative and qualitative data to obtain more in-depth results. The study results show that these community activities produced word-of-mouth to create intention among the young generation. The resulting word-of-mouth positively affected their interest in participating in the agricultural sector mediated by the Theory of Planned Behavior variables. The evidence lies in the number of young people who shared their farming activities voluntarily on social media and their involvement in various activities organized by the community.
Abstrak
Sektor pertanian merupakan sektor vital bagi kelangsungan hidup Indonesia. Namun salah satu kendala yang dihadapi adalah kaderisasi petani karena tidak semua generasi muda mau berpartisipasi di sektor ini. Salah satu komunitas yang merespons kondisi ini adalah Aku Petani Indonesia. Komunitas ini melakukan berbagai kegiatan untuk menumbuhkan niat untuk berpartisipasi dalam kegiatan pertanian di kalangan generasi muda. Penelitian ini bertujuan untuk mempelajari bagaimana kegiatan tersebut menciptakan word-of-mouth yang dapat menimbulkan niat. Theory of Planned Behavior pada penelitian digunakan sebagai kerangka teoritis. Desain penelitian ini adalah triangulasi konkuren, yaitu menggabungkan data kuantitatif dan kualitatif untuk mendapatkan hasil yang lebih mendalam. Hasil penelitian menunjukkan bahwa kegiatan komunitas ini menghasilkan word-of-mouth yang mampu membentuk intensi di kalangan generasi muda. Word-of-mouth yang dihasilkan berpengaruh positif terhadap intensi untuk berpartisipasi di sektor pertanian yang dimediasi oleh variabel Theory of Planned Behavior. Hal ini dibuktikan dengan banyaknya anak muda yang membagikan kegiatan bertani secara sukarela di media sosial dan keterlibatan mereka dalam berbagai kegiatan yang diselenggarakan oleh masyarakat.
CELL INCORPORATION STUDY OF [99mTc]Tc-NAB-PACLITAXEL ON HUMAN COLORECTAL ADENOCARCINOMA CELL LINE
Authors: EKİNCİ Meliha , İLEM-ÖZDEMİR Derya 
Published: December 2022

Objective: The development of new radiopharmaceuticals capable of specifically imaging cancer is an important research area. For this reason, the aim of this study is to investigate cell binding of novel developed nanoradiopharmaceutical ([99mTc]Tc-nab-PTX) on HT-29 cell line (human colorectal adenocarcinoma cells).
Material and Method: In this study, nab-PTX was labeled with [99mTc]Tc, and labeling efficiency and in vitro stability were investigated by radioactive thin layer chromatography (RTLC). Then, cell incorporation of [99mTc]Tc-nab-PTX was performed using HT-29 cell line.
Result and Discussion: According to obtained results, nab-PTX was labeled with high radiochemical purity (>99%). The [99mTc]Tc-nab-PTX was found to be stable in saline for 6-h, and in cell medium up to 2-h. It was determined that [99mTc]Tc-nab-PTX had a greater cell binding activity on HT-29 cells than R/H-[99mTc]NaTcO4 at 30 min. The results were found to be promising for future in vivo studies with [99mTc]Tc-nab-PTX.
Potential diagnostic of lymph node metastasis and prognostic values of TM4SFs in papillary thyroid carcinoma patients
Authors: Wang Kun , Li Haomin , Zhao Junyu , Yao Jinming , Lu Yiran , Dong Jianjun , Bai Jie , Liao Lin 
Published: December 2022

Background: Although the prognosis of papillary thyroid carcinoma (PTC) is relatively good, it causes around 41,000 deaths per year, which is likely related to recurrence and metastasis. Lymph node metastasis (LNM) is an important indicator of PTC recurrence and transmembrane 4 superfamily (TM4SF) proteins regulate metastasis by modulating cell adhesion, migration, tissue differentiation, and tumor invasion. However, the diagnostic and prognostic values of TM4SF in PTC remain unclear.Methods: This study aimed to identify TM4SF genes with predictive value for LNM and prognostic value in PTC using bioinformatic analysis. We screened the differentially expressed genes (DEGs) of the TM4SF family in PTC using data from TCGA, constructed a PPI network using STRING, and evaluated the predictive role of TM4SF1 in LNM via a binary logistic regression analysis and ROC curve. We assessed the association between TM4SF1 expression and DNA methylation, and determined the functional and mechanistic role of TM4SF1 in promoting LNM via GSEA, KEGG, and GO. We estimated the relationship between each TM4SF gene and overall survival (OS, estimated by Kaplan-Meier analysis) in patients with PTC and established a predictive model of prognostic indicators using a LASSO penalized Cox analysis to identify hub genes. Finally, we explored the correlation between TM4SFs and TMB/MSI.Results: We identified 21 DEGs from the 41 TM4SFs between N0 (without LNM) and N1 (with LNM) patients, with TM4SF1, TM4SF4, UPK1B, and CD151 being highly expressed in the N1 group; several DEGs were observed in the TNM, T, and N cancer stages. The “integrins and other cell-surface receptors” pathway was the most significantly enriched functional category related to LNM and TM4SFs. TM4SF1 was identified as an indicator of LNM (AUC= 0.702). High levels of TM4SF1 might be related to Wnt/β-catenin pathway and epithelial–mesenchymal transition (EMT) process in PTC. The higher expression of TM4SF1 was also related to DNA promoter hypomethylation. CD9, TM4SF4, TSPAN2, and TSPAN16 were associated with OS in PTC patients and TSPAN2 has great potential to become a prognostic marker of PTC progression. For the prognostic model, the riskscore = (-0.0058)*CD82+(-0.4994)*+(0.1584)*TSPAN11+(1.7597)*TSPAN19+(0.2694)*TSPAN2 (lambda.min = 0.0149). The AUCs for 3-year, 5-year, and 10-year OS were 0.81, 0.851, and 0.804. TSPAN18, TSPAN31, and TSPAN32 were associated with both TMB and MSI in PTC patients.Conclusion: Our findings identified TM4SF1 as a potential diagnostic marker of LNM and TSPAN2 as a prognostic factor for patients with PTC. Our study provides a novel strategy to assess prognosis and predict effective treatments in PTC.
Risk factors, clinical features, and outcomes of patients with hypertrophic cardiomyopathy complicated by ischemic stroke: A single-center retrospective study
Authors: Lu Jian-Feng , Fan Ze-Xin , Li Ying , Wang Ze-Yi , Ma Lin , Yuan Bo-Yi , Yang Ting-Ting , Liu Pen-Ju , Liu Guang-Zhi 
Published: December 2022

ObjectiveThis study aimed to explore risk factors, clinical features, and prognosis of patients with hypertrophic cardiomyopathy (HCM) complicated by ischemic stroke (IS).MethodsWe conducted a retrospective analysis of all HCM patient data and a 1-year follow-up study.ResultsTotally, 506 patients with HCM, including 71 with IS, were enrolled. Older age (≥63 years) was associated with an increased risk of IS in HCM patients (OR = 1.045, 95% CI: 1.018–1.072, p = 0.001). Among 37 patients complicated by IS, 22 (59.5%, 22/37) manifested as cardioembolism (CE) subtype, and 13 (35.1%, 3/37) small artery occlusion (SAO) subtype, according to TOAST classification. In the acute phase, the IS patients presented with NIHSS 4 (interquartile range: 1, 10). Multi-infarction was more common than single infarction (72.7 vs. 27.3%), while cortical + subcortical infarction (CE group: 50%) or subcortical infarction (SAO group: 53.8%) constituted most IS cases. Additionally, the blood supply areas of anterior circulation (CE group: 45.5%; SAO group: 92.3%) or anterior + posterior circulation (CE group: 50%) were mainly involved. The 1-year survival rate of HCM patients with concomitant IS was 81.8%, and IS was associated with 1-year all-cause death in HCM patients (HR = 5.689, 95% CI: 1.784–18.144, p = 0.003).ConclusionOlder age is a risk factor for IS occurrence in HCM patients. Patients with HCM complicated by IS had mild or moderate neurologic deficits at disease onset. CE and SAO subtypes predominate in patients with concomitant IS, especially the former. Multiple cortical and subcortical infarctions are their neuroimaging characteristics, mainly involving the anterior circulation or anterior + posterior circulation. Is is a risk factor for all-cause death in HCM patients within 1 year.
A newly identified cryogenian (ca. 806 ma) basement tonalite gneiss from the Eastern Karakoram, NW India: Constraints from geochemistry and zircon U-Pb geochronology
Authors: Pundir Shailendra , Adlakha Vikas , Kumar Santosh , Singhal Saurabh , Das Satyabrata 
Published: December 2022

The Karakoram Terrane (KT) represents the southern margin of the Eurasian Plate, mainly consisting of Late Jurassic-Early Cretaceous subduction-related granites and post-collisional Miocene leucogranites, which intrude the Late Neo-Proterozoic basement. We report for the first time the existence of the Cryogenian KT basement as recorded from the geochemistry and geochronology of tonalite gneiss (ca. 806 Ma) in the southeastern Karakoram terrane, NW India. Geochemically, the studied tonalite gneiss is slightly peraluminous (Molar Al2O3/CaO+Na2O+K2O=1.1), calc-alkaline volcanic-arc granitoid, strongly fractionated REE (LaN/YbN=33.99), and high Sr/Y =19.75, more akin to its affinity with Tonalite–trondhjemite–granodiorite (TTG)/adakite. The whole-rock elemental data suggest that tonalite gneiss is more likely sourced from ancient mafic lower crust where garnet remained in the residue. The petrogenetic modeling of REE suggests that the melt similar to the observed tonalite gneiss can be generated through ∼50% partial melting of a mafic lower crust with garnet, clinopyroxene, and amphibole assemblage. The synthesis and comparison of present and published Proterozoic magmatic records on the rocks from KT strongly dictate that the produced partial melt similar to observed tonalite gneiss most likely served as the parental melt for the development of TTGs in the Southern Pamir and more evolved granitoid in the Central Tibetan terrane. We propose that the studied tonalite gneiss from the southeast Karakoram is a product of Neoproterozoic Andean-type orogeny formed on the northwestern margin of the Rodinia supercontinent. Thus, our study favors the first time, the position of KT within the Cimmerian belt along with other East Asian continental blocks.
Risk prediction model establishment with tri-phasic CT image features for differential diagnosis of adrenal pheochromocytomas and lipid-poor adenomas: Grouping method
Authors: Niu Zhongfeng , Wang Jian , Yang Yang , He Jie , Wang Subo , Xie Zongyu , Shao Meihua , Zhu Fangmei 
Published: December 2022

ObjectivesThe purpose of this study was to establish a risk prediction model for differential diagnosis of pheochromocytomas (PCCs) from lipid-poor adenomas (LPAs) using a grouping method based on tri-phasic CT image features.MethodsIn this retrospective study, we enrolled patients that were assigned to a training set (136 PCCs and 183 LPAs) from two medical centers, along with an external independent validation set (30 PCCs and 54 LPAs) from another center. According to the attenuation values in unenhanced CT (CTu), the lesions were divided into three groups: group 1, 10 HU &lt; CTu ≤ 25 HU; group 2, 25 HU &lt; CTu ≤ 40 HU; and group 3, CTu &gt; 40 HU. Quantitative and qualitative CT imaging features were calculated and evaluated. Univariate, ROC, and binary logistic regression analyses were applied to compare these features.ResultsCystic degeneration, CTu, and the peak value of enhancement in the arterial and venous phase (DEpeak) were independent risk factors for differential diagnosis of adrenal PCCs from LPAs. In all subjects (groups 1, 2, and 3), the model formula for the differentiation of PCCs was as follows: Y = -7.709 + 3.617*(cystic degeneration) + 0.175*(CTu ≥ 35.55 HU) + 0.068*(DEpeak ≥ 51.35 HU). ROC curves were drawn with an AUC of 0.95 (95% CI: 0.927–0.973) in the training set and 0.91 (95% CI: 0.860–0.929) in the external validation set.ConclusionA reliable and practical prediction model for differential diagnosis of adrenal PCCs and LPAs was established using a grouping method.
A pan-cancer analysis of the prognostic value of long non-coding RNA LINC00662 in human cancers
Authors: Zhang Guangming , Wu Bin , Fu Liangyin , Liu Bin , Han Xiaoyong , Wang Jie , Zhang Yipeng , Yu Miao , Ma Haizhong , Ma Shixun , Cai Hui 
Published: December 2022

Background: Numerous studies have revealed that the long non-coding RNA LINC00662 is irregularly expressed in various cancers, as well as is correlated with cancer development and progression. Nevertheless, the clinical value of LINC00662 remains controversial. Hence, we explored the correlation of LINC00662 with cancer prognosis through meta-analysis and bioinformatics analysis.Methods: From the beginning through 12 March 2022, we searched for correlational studies on Web of Science, Embase, PubMed and The Cochrane Library. We used pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) to determine the significance of studies on survival outcomes and clinicopathological aspects in human cancers. Additionally, the Gene Expression Profiling Interactive Analysis (GEPIA) database was employed to confirm our findings.Results: Our meta-analysis of 14 studies comprising a total of 960 cancer patients revealed that LINC00662 overexpression was correlated with poor overall survival (HR = 1.91, 95% CI 1.49–2.45, p &lt; 0.001) in cancer patients and relapse-free survival (HR = 2.12, 95% CI 1.19–3.76, p = 0.010) in hepatocellular carcinoma patients. The correlation between LINC00662 and OS was further supported by the results of subgroup analyses according to cancer type, follow-up time, HR availability, and NOS score. In addition, LINC00662 overexpression predicted advanced tumor stage (OR = 4.23, 95% CI 2.50–7.17, p &lt; 0.001), larger tumor size (OR = 1.49, 95% CI 1.11–1.99, p = 0.008), earlier lymph node metastasis (OR = 2.40, 95% CI 1.25–4.59, p = 0.008), and earlier distant metastasis (OR = 4.78, 95% CI 2.57–8.88, p &lt; 0.001). However, there were no statistically significant differences in age (OR = 1.16, 95% CI 0.90–1.51, p = 0.246), gender (OR = 1.10, 95% CI 0.79–1.53, p = 0.578), or differentiation grade (OR = 1.53, 95% CI 0.71–3.33, p = 0.280).Conclusion: LINC00662 expression upregulation is associated with poor prognosis and advanced clinicopathological features in patients with multiple tumors. LINC00662 may serve as a biomarker for the diagnosis and treatment of patients with tumors.
Identification of immune microenvironment subtypes and signature genes for Alzheimer’s disease diagnosis and risk prediction based on explainable machine learning
Authors: Lai Yongxing , Lin Peiqiang , Lin Fan , Chen Manli , Lin Chunjin , Lin Xing , Wu Lijuan , Zheng Mouwei , Chen Jianhao 
Published: December 2022

BackgroundUsing interpretable machine learning, we sought to define the immune microenvironment subtypes and distinctive genes in AD.MethodsssGSEA, LASSO regression, and WGCNA algorithms were used to evaluate immune state in AD patients. To predict the fate of AD and identify distinctive genes, six machine learning algorithms were developed. The output of machine learning models was interpreted using the SHAP and LIME algorithms. For external validation, four separate GEO databases were used. We estimated the subgroups of the immunological microenvironment using unsupervised clustering. Further research was done on the variations in immunological microenvironment, enhanced functions and pathways, and therapeutic medicines between these subtypes. Finally, the expression of characteristic genes was verified using the AlzData and pan-cancer databases and RT-PCR analysis.ResultsIt was determined that AD is connected to changes in the immunological microenvironment. WGCNA revealed 31 potential immune genes, of which the greenyellow and blue modules were shown to be most associated with infiltrated immune cells. In the testing set, the XGBoost algorithm had the best performance with an AUC of 0.86 and a P-R value of 0.83. Following the screening of the testing set by machine learning algorithms and the verification of independent datasets, five genes (CXCR4, PPP3R1, HSP90AB1, CXCL10, and S100A12) that were closely associated with AD pathological biomarkers and allowed for the accurate prediction of AD progression were found to be immune microenvironment-related genes. The feature gene-based nomogram may provide clinical advantages to patients. Two immune microenvironment subgroups for AD patients were identified, subtype2 was linked to a metabolic phenotype, subtype1 belonged to the immune-active kind. MK-866 and arachidonyltrifluoromethane were identified as the top treatment agents for subtypes 1 and 2, respectively. These five distinguishing genes were found to be intimately linked to the development of the disease, according to the Alzdata database, pan-cancer research, and RT-PCR analysis.ConclusionThe hub genes associated with the immune microenvironment that are most strongly associated with the progression of pathology in AD are CXCR4, PPP3R1, HSP90AB1, CXCL10, and S100A12. The hypothesized molecular subgroups might offer novel perceptions for individualized AD treatment.
Increased formation of neutrophil extracellular traps in patients with anti-N-methyl-d-aspartate receptor encephalitis
Authors: Qiao Shan , Sun Quan-ye , Zhou Peng , Zhang Shan-chao , Wang Zhi-hao , Li Hai-yun , Wang Ai-hua , Liu Xue-wu , Xin Tao 
Published: December 2022

BackgroundNeutrophil extracellular traps (NETs) have been found to play an important role in several nervous system diseases. However, their role in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis remains unclear. The purpose of this study was to examine the possible role of NETs in anti-NMDAR encephalitis.Materials and methodsEleven patients with anti-NMDAR encephalitis and ten healthy participants were enrolled. Plasma NETs levels were detected using an immunofluorescence assay and enzyme-linked immunosorbent assay. Additionally, we examined 10 plasma cytokines in patients with anti-NMDAR encephalitis and analyzed the correlation between citrullinated histone 3 levels and cytokine release. ResultsPeripheral blood neutrophils from patients with anti-NMDAR encephalitis were more susceptible to NET generation. When compared with controls, cases of anti-NMDAR encephalitis showed elevated levels of IL-1 α, IL-6, IL-8, IL-13, MCP-1, and TNF-α (p &lt; 0.05). Moreover, IL-6, IL-8, and TNF-α levels were positively correlated with H3Cit levels.ConclusionWe provide evidence that NETs may play a role in anti-NMDAR encephalitis, providing clues for elucidation of the pathogenesis of this disease.