bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-intensity pulsed ultrasound promotes cell viability and inhibits apoptosis of H9C2 cardiomyocytes in 3D bioprinting scaffolds via PI3K-Akt and ERK1/2 pathways
Authors: Hu Yugang , Jia Yan , Wang Hao , Cao Quan , Yang Yuanting , Zhou Yanxiang , Tan Tuantuan , Huang Xin , Zhou Qing 
Published: May 2022

The aim of this study was to investigate whether low-intensity pulsed ultrasound (LIPUS) promotes myocardial cell viability in three-dimensional (3D) cell-laden gelatin methacryloyl (GelMA) scaffolds. Cardiomyoblasts (H9C2s) were mixed in 6% (w/v) GelMA bio-inks and printed using an extrusion-based 3D bioprinter. These scaffolds were exposed to LIPUS with different parameters or sham-irradiated to optimize the LIPUS treatment. The viability of H9C2s was measured using Cell Counting Kit-8 (CCK8), cell cycle, and live and dead cell double-staining assays. Western blot analysis was performed to determine the protein expression levels. We successfully fabricated 3D bio-printed cell-laden GelMA scaffolds. CCK8 and live and dead cell double-staining assays indicated that the optimal conditions for LIPUS were a frequency of 0.5 MHz and an exposure time of 10 min. Cell cycle analysis showed that LIPUS promoted the entry of cells into the S and G2/M phases from the G0/G1 phase. Western blot analysis revealed that LIPUS promoted the phosphorylation and activation of ERK1/2 and PI3K-Akt. The ERK1/2 inhibitor (U0126) and PI3K inhibitor (LY294002) significantly reduced LIPUS-induced phosphorylation of ERK1/2 and PI3K-Akt, respectively, which in turn reduced the LIPUS-induced viability of H9C2s in 3D bio-printed cell-laden GelMA scaffolds. A frequency of 0.5 MHz and exposure time of 10 min for LIPUS exposure can be adapted to achieve optimized culture effects on myocardial cells in 3D bio-printed cell-laden GelMA scaffolds via the ERK1/2 and PI3K-Akt signaling pathways.
Only “yes” means “yes”: Negotiation of Sex and Its Link With Sexual Violence
Authors: Moyano Nieves , Sánchez-Fuentes María del Mar , Parra-Barrera Sandra Milena , Granados de Haro Reina 
Published: May 2022

Lack of consent is an essential characteristic of sexual violence. The present study was conducted to analyze the relation between sexual consent and the risk of perpetrating sexual aggression by men and victimization suffered by women in more depth. The sample consisted of 1681 heterosexual Spanish men and women aged 18–66 years. The participants completed an online survey containing the Spanish versions of the Sexual Consent Scale Revised and the Sexual Experiences Survey. The results showed that 70.2% of the women had been sexual victims, and 20.8% of men reported having perpetrated sexual violence. On the one hand, sexual aggressors, unlike non aggressors, underestimated the relevance of obtaining sexual consent, and more aggressors reported lack of perceived behavioral control for requesting sexual consent and endorsed less positive attitudes to obtain sexual consent than non aggressors. On the other hand, sexual victims, compared to non victims, considered requesting explicit sexual consent relevant, but held certain ideas, attitudes, and behaviors that did not go along with obtaining sexual consent, which leaves women in a position of vulnerability.
Parental Education and Child Physical Health Following the BP Deepwater Horizon Oil Spill
Authors: Stroope Samuel , Kroeger Rhiannon A. , Slack Tim , Keating Kathryn Sweet , Beedasy Jaishree , Chandler Thomas , Sury Jonathan J. , Brooks Jeremy 
Published: May 2022

Purpose: To assess whether trajectories of children’s physical health problems differ by parental college degree attainment in Louisiana areas highly impacted by the 2010 BP Deepwater Horizon oil spill (BP-DHOS). Design: Three waves of panel data (2014, 2016, and 2018) from the Gulf Coast Population Impact / Resilient Children, Youth, and Communities studies. Setting: BP-DHOS-impacted communities in coastal Louisiana. Participants: Parents of children aged 4-18 in a longitudinal probability sample (n = 392). Measures: Reported child physical health problems from the BP-DHOS, parental college degree attainment, and covariates. Analysis: Linear growth curve models are used to assess initial levels of and the rate of change in child physical unknown. The current study uses 3 waves physical health problems by parental college degree attainment. Explanatory variables are measured at baseline and the outcome variable is measured at all 3 waves. Results: Compared to children of parents without college degrees, children of college graduates had fewer initial health problems in 2014 (b = −.33; p = .02). Yet, this health advantage decreased over time, as indicated by their positive rate of change (b = .22; p = .01), such that the higher education health advantage was not statistically significant by 2018. Conclusion: Children of college graduates experienced a physical health advantage following the BP-DHOS, but this gap closed over time. The closure of the gap was due to the children of college graduates experiencing significant increases in reported health problems over the study period.
Association between asthma control and healthcare costs: Results from a German linked data study
Authors: Wilke Thomas , Timmermann Hartmut , Mueller Sabrina , Hardtstock Fraence , Unmuessig Victoria , Welte Robert R , Maywald Ulf 
Published: May 2022

Background: This study aimed to evaluate differences in healthcare resource utilization and cost among patients with controlled and uncontrolled asthma. Methods: Claims data from a German sickness fund was linked to patient survey data. Outpatient physicians enrolled patients and assessed asthma control using the ACTTM questionnaire. All-cause and asthma-specific healthcare resource use (HCRU)/costs were compared descriptively and based on multivariable models using a continuous ACTTM score. Results: Overall, 492 asthma patients were included (mean age: 53.8, 73.8% female). The mean/median ACTTM score was 19.9/20.7, with 183 patients (37.2%) classified as having uncontrolled asthma (mean ACTTM score<20) Patients with uncontrolled asthma had significantly more hospitalizations ( p = .035) and medication prescriptions ( p < .001), which resulted in higher total healthcare costs for asthma-related (€1785 vs. €1615; p = .004) and all-cause care (€4695 vs. €4117; p = .009). While controlling for baseline characteristics, multivariable models confirmed a negative association between asthma control and total all-cause healthcare costs ( p = .008), total asthma-related costs ( p = .008), and costs of medication prescriptions ( p = .001). However, no significant association was found for all-cause ( p = .062) and asthma-related hospitalization costs ( p = .576). Conclusion: Considering continuous patient care, improving asthma control is not only desirable from a clinical perspective, but could also be an effective approach to reduce asthma-related HCRU and cost burden.
Determination of abrasion resistance of Fe28Cr5C1Mn coating applied to 30MnB5 boron alloy cultivator blades via electric arc spray
Authors: Güney Bekir , Dilay Yusuf 
Published: May 2022

The poor abrasive wear behavior of agricultural machinery affects the farmers all over the world, rendering their activities more inefficient and negatively affecting their productivity. Therefore, innovation in the manufacture of soil cultivation machinery and the selection of wear-resistant materials has been of great importance. Recently, boron alloys, in particular, have been used in the manufacture of machinery parts that work the soil. The aim of this was to investigate the behavior of the blades of the machines widely used in soil cultivation in agricultural production following a surface treatment technique. For this purpose, the blades made of 30MnB5, a material widely used in the production of cultivator blades, were used as substrate samples in the trials as well as blades of the same substrate coated with Fe28Cr5C1Mn alloy wire via the electric arc spray technique. The morphologies and structures of the uncoated and coated samples were comprehensively analyzed by light microscopy, scanning electron microscopy, energy dispersive spectrometry and X-ray diffraction. In addition, their microhardness, porosity, and surface roughness properties were assessed separately before and after plowing. These prepared blades were tested under in the same conditions by plowing the same field at two different soil moisture. Although the weight loss was measured as 9.4 g and 5.4 g in the uncoated and in the coated sample at 9% moisture level, respectively, the weight losses were at 14% humidity level were 10.6 g and 5.9 g in the uncoated and coated samples, respectively. Although the amount of wear increased with increasing humidity levels in both groups, the mass wear loss in cultivator blades coated with Fe25Cr5C1Mn alloy wire was found to be lower in all trials. The results suggest that coating the cultivator blades using electric arc spray would increase agricultural productivity and reduce factors that cause environmental pollution.
Experimental study on electric corrosion damage of bearing and solution
Authors: Huan Jie , Li Songhua , Xia Zhongxian , Wang Yonghua , Wang Weinan , Shi Guangda 
Published: May 2022

During the operation of the bearing in the motor, the induced current will inevitably be generated. The bearing raceway will be damaged by current. In this paper, the oil film thickness and capacitance in the bearing are analyzed in detail, and the relationship between oil film thickness, rotational speed, and load is obtained. The oil film thickness increases with the increase of bearing rotation speed and decreases slightly with the increase of load. The minimum oil film thickness of the bearing is between 0.4 μm and 2.9 μm. The capacitance of bearing is influenced by Hertz contact area, oil film thickness, and lubricant quality. It is between 1.9 pF and 34.7 pF. A shaft current test rig was developed. Based on the analysis results, orthogonal tests are set up to study the influence of voltage, rotation speed, and load on bearing operation. By using range analysis and variance analysis, the same conclusion is obtained: the most dominant factors affecting the raceway damage width, surface roughness, and vibration amplitude are voltage, load, and rotation speed, respectively. The mixed ceramic bearing and full-ceramic bearing are used instead of steel bearing to solve the problem of shaft current. Add conductive grease and non-conductive grease, respectively, and analyze and compare the advantages and disadvantages of different combinations from the perspective of temperature and friction and wear. The order from inferior to superior is steel bearing, hybrid ceramic bearing with ceramic outer ring, hybrid ceramic bearing with ceramic inner ring, hybrid ceramic bearing with ceramic ball and full-ceramic bearing. By using non-conductive grease, the damage is reduced by 16%–29%, surface roughness is reduced by 90%–122%, and vibration is reduced by 23%–176%. Under the same conditions, the bearings using non-conductive grease are better than those using conductive grease.
Professional values in student nurse education: An integrative literature review
Authors: Antoniou Carolyn , Clifton Ross , Wilson Valerie 
Published: May 2022

Aim The aim is to understand current research into the impact of undergraduate nursing education on the development of professional values. Background Values are evident in the professional standards for nurses and the guidelines and healthcare policies of many countries. These professional values guide decisions and behaviour and are recognised as an essential component in the professions ability to provide safe and professional care. This literature review presents the current research on the impact of education on professional values in undergraduate nurse education. Design An integrative review of the findings was conducted to provide insight into the current research on the professional value development in undergraduate nurses. Data sources CINAHL, PubMed and Scopus. Review methods A literature search was undertaken within defined date parameters 2010–2021 using a systematic approach. The Preferred Reporting Items for Systematic Reviews and Meta-analysis guide PRISMA was used to guide and illustrate the process. Papers were assessed for quality using the Mixed Methods Appraisal Tool. Results Two distinct areas of inquiry were identified. (a) Changes in professional values as an outcome of undergraduate nursing education or (b) changes in professional values as an outcome of specifically designed educational content. These areas were further explored to better understand the influences of undergraduate education on students’ professional values. Conclusion There is a lack of evidence in the literature to support the premise that professional values develop in line with academic year progression; however, there is strong evidence to support the inclusion of explicit learning in undergraduate education that engages students in education specifically designed to explore and develop professional values.
A longer duration from injury to surgery is associated with preoperative deterioration of an isolated meniscal tear in patients aged 40 years or older
Authors: Yokoe Takuji , Tajima Takuya , Yamaguchi Nami , Morita Yudai , Chosa Etsuo 
Published: May 2022

Purpose To evaluate the preoperative deterioration of an isolated meniscal tear in patients aged 40 years or older, and whether time from injury to surgery is associated with worsening of a meniscal tear. Methods Patients aged 40 years or older who underwent arthroscopic surgery for isolated meniscal tear between 2014 and 2019 were retrospectively reviewed. The diagnostic magnetic resonance imaging (MRI) findings and arthroscopic findings were compared to evaluate the deterioration of meniscal tears. Predictors of the development of meniscal tears; patient demographic factors, duration from injury to surgery (injury to MRI and MRI to surgery), and image findings were assessed. Results A total of 58 patients (58 knees) were included (mean age, 55.9 ± 8.5 years; male/female, 31/27). An isolated meniscal tear deteriorated in 28 (48.3%). Compared patients with and without deteriorated meniscal tear, significant differences were found in the MRI grade of meniscal tear ( p = 0.03), duration from injury to MRI (164.2 ± 167.9 vs 45.2 ± 48.7 days, p < 0.001), and from MRI to surgery (148.8 ± 91.1 vs 67.6 ± 56.7 days, p < 0.001). A multivariate regression analysis showed that the duration from injury to MRI (odds ratio [OR], 1.03; p < 0.001) and from MRI to surgery (OR, 1.02; p < 0.001) were independent predictors. Conclusion Approximately 50% of isolated meniscal tears deteriorated preoperatively in patients aged 40 years or older. The duration from injury to surgery was an independent predictor of worsening of an isolated meniscal tear.
Trans tibial amputation with or without a tourniquet in patients with diabetic foot infection and peripheral vascular disease: Comparison of postoperative outcomes
Authors: Gurel Ron , Elbaz Etay , Ashkenazi Itay , Rotman Dani , Factor Shai , Chechik Ofir , Warschawski Yaniv , Albagli Assaf 
Published: May 2022

Background: Transtibial amputation (TTA) due to complications of diabetic foot infection (DFI) or peripheral vascular disease (PVD) is a high-risk procedure in fragile patients. The risks of reoperation, blood loss requiring blood transfusion, and mortality are high. The use of a tourniquet in this procedure is controversial and scarcely reported. Objective: this study aimed to compare the outcomes of TTAs with or without a tourniquet in a single tertiary medical center. Methods: We retrospectively identified all patients who had undergone TTA in our institution (1/2019-1/2020) and included only those who underwent the procedure due to complications of DFI or PVD ( n = 69). The retrieved data included demographics, comorbidities, ASA score, the use of a tourniquet, operation duration, pre- and postoperative hemoglobin levels, administration of blood transfusions, hospitalization length, surgical site infection and 60-days reoperation and mortality rates. Results: TTA with a tourniquet was superior to TTA without a tourniquet in reducing the average operation length by 11 min ( p = 0.05), the median postoperative hospitalization by 6 days ( p = 0.04), and the use of blood transfusions (odds ratio [OR] = 0.176, 95% confidence interval [CI]: 0.031–0.996). Conclusions: Our findings demonstrated advantages in operative time, hospitalization length, and blood transfusion requirement for TTA with a tourniquet compared to TTA without a tourniquet.
Rapid review and commentary on the clinical implications of the population mental health consequences of the COVID-19 pandemic in Australia
Authors: Looi Jeffrey CL , Allison Stephen , Bastiampillai Tarun , Kisely Stephen R 
Published: May 2022

Objective To provide a rapid clinical review and commentary for psychiatrists on the population mental health consequences of the COVID-19 pandemic in Australia, including evidence-based findings and interventions. Conclusions Whilst there was evidence of collective psychological resilience during the first 2 years of the COVID-19 pandemic, younger women, carers for those with COVID-19, and those with more household chores, childcare needs and higher economic strain, were at more risk. Interventions should therefore target people with these socio-demographic risk factors, as well as severe COVID-19 survivors, their relatives and frontline workers. However, the rapid spread of the Omicron SARS-CoV-2 variant has the potential for greater impacts on population mental health. Innovations in telehealth and online therapy should be incorporated into standard care. Ongoing research is needed to assess who remains most vulnerable to negative mental health impacts of the current pandemic, and especially the longer term outcomes of mental ill health. Further research should also investigate evidence-based approaches to resilience and well-being. Prospective risk/benefit analyses of infection control measures, economic effects and mental health consequences are needed.
Psychometric Properties of a European French Version of the PTGI
Authors: Henson Charlotte , Truchot Didier , Canevello Amy , Andela Marie 
Published: May 2022

Purpose To validate a European French translation of the Posttraumatic Growth Inventory (PTGI). Methods This study examined the factorial and the convergent validity of the French version of the PTGI (PTGI-F). A first sample of 406 firefighters was used to test the psychometric structure of the PTGI. A second sample of 210 first responders was then used to test its convergent validity. Participants completed measures of growth, traumatic events, PTSD, anxiety and depression, and personality. Results The PTGI-F was unrelated to Anxiety, supporting the convergent validity of the PTGI-F. Additionally, there was a positive correlation between the PTGI-F and the PCL-C. Finally, the PTGI-F had the same five-factor structure as the PTGI. Discussion The PTGI-F appears to be a valid tool. However, the contradictions that were put froward by other translated versions suggest that the PTGI should be reconsidered and improved to better assess the growth process.
A Retrospective Study Analyzing a Palliative Care-Hospital Medicine Collaboration to Improve Quality of Care of Patients With Advanced Illness
Authors: Anandan Samuel , Reyes Andre , Izard Stephanie , Magalee Christopher J. , Lopez Santiago 
Published: May 2022

Background Palliative care seeks to improve outcomes for patients with advanced illness (AI). Advocacy exists for making it part of mainstream care for hospitalized patients with AI. Aim To determine if a partnership between hospital-medicine and specialized palliative care would increase identification of AI patients with palliative care needs requiring palliative consultation. Secondary outcomes: Decreasing 30-day readmission, length of stay (LOS) and pain scores, increasing documentation reflecting goals and advanced care planning. Design Retrospective chart review of patients with AI admitted to a hospitalist-resident run unit divided into Care Models, “A” and “B,” and analyzed over two ten-month periods, “1” and “2.” Triggers for palliative needs were provided for “A.” During biweekly rounding, needs were assessed and generalist vs. specialist level palliative care concepts were used for consultation. Setting Quaternary-level teaching center in the New York Metropolitan area. Patients 3,395 AI patients were analyzed, 1,707 from “1,” and 1,688 from “2.” Results Comparing care models and time frames, palliative care consultation increased in “A” ( P-value = .0013, P-value = .0005). When investigating “A” in “1” to “2,” CMI was higher. Comparing “B” between “1” and “2,” found older age and lower LACE. When adjusting for confounders (LACE and CMI), our models did not show a difference. Data on discharge disposition was significant for subacute rehab but not for mortality. There were no differences between care models and time-periods for secondary outcomes. Conclusion Our study demonstrated the demand for palliative care services integrated into hospital medicine and highlighted areas of focus for future studies.
Palliative Care in Breast Cancer During the COVID-19 Pandemic: A Scoping Review
Authors: Velasco Yanez Romel , Frota Goyanna Natália , Carvalho Fernandes Ana , Moura Barbosa Castro Régia , Holanda da Cunha Gilmara , Silva Ferreira Iarlla , Miranda Mattos Samuel , Magalhães Moreira Thereza 
Published: May 2022

Background: The COVID-19 pandemic has harmed the provision of palliative care (PC) services for women with breast cancer due to all the restrictions that came along with the virus. Objective: To map the available evidence on the situation of PC in breast cancer during the COVID-19 pandemic. Methods: A scoping review was carried out based on the methodology proposed by the Joanna Briggs Institute. The search was conducted in nine databases, one electronic repository, and one library, using controlled vocabularies. Results: Twenty-nine articles and seven documents were included. The majority (11.4% each) were published in the United Kingdom, Italy, and the United States, 38.9% addressed palliative radiotherapy (RT), and 47.2% consisted of recommendations. From the content analysis, five categories were obtained focused on the recommendations on changes in palliative treatment guidelines and the response of PC teams to the evolving crisis. Conclusions: The evidence pointed to the management of general PC, palliative RT, palliative chemotherapy, management of metastatic breast cancer, and use of technologies in palliative care. No recommendations were found to manage frequent symptoms in PC, indicating the need to develop primary studies that investigate these aspects in detail in this vulnerable group. Implications: The results contained in this document can provide professionals working in this field of care with a global view of how other teams have dealt with the pandemic, thereby identifying the best guidelines to apply in their reality, taking into account the clinical and social situation of each patient.