bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catch bonds in sickle cell disease: shear-enhanced adhesion of red blood cells to laminin
Authors: Goreke Utku , Iram Shamreen , Singh Gundeep , Domínguez-Medina Sergio , Man Yuncheng , Bode Allison , An Ran , Little Jane A. , Wirth Christopher L. , Hinczewski Michael , Gurkan Umut A. 
Published: November 2022

ABSTRACTCould the phenomenon of catch bonding—force-strengthened cellular adhesion—play a role in sickle cell disease, where abnormal red blood cell (RBC) adhesion obstructs blood flow? Here we investigate the dynamics of sickle RBCs adhering to a surface functionalized with the protein laminin (a component of the extracellular matrix around blood vessels) under physiologically relevant micro-scale flow. First, using total internal reflectance microscopy we characterize the spatial fluctuations of the RBC membrane above the laminin surface before detachment. The complex dynamics we observe suggest the possibility of catch bonding, where the mean detachment time of the cell from the surface initially increases to a maximum and then decreases as a function of shear force. We next conduct a series of shear-induced detachment experiments on blood samples from 25 sickle cell disease patients, quantifying the number and duration of adhered cells under both sudden force jumps and linear force ramps. The experiments reveal that a subset of patients does indeed exhibit catch bonding. By fitting the data to a theoretical model of the bond dynamics, we can extract the mean bond lifetime versus force for each patient. The results show a striking heterogeneity among patients, both in terms of the qualitative behavior (whether or not there is catch bonding) and in the magnitudes of the lifetimes. Patients with large bond lifetimes at physiological forces are more likely to have certain adverse clinical features, like a diagnosis of pulmonary arterial hypertension and intracardiac shunts. By introducing anin vitroplatform for fully characterizing RBC-laminin adhesion dynamics, our approach could contribute to the development of patient-specific anti-adhesive therapies for sickle cell disease. The experimental setup is also easily generalizable to studying adhesion dynamics in other cell types, for example leukocytes or cancer cells, and can incorporate disease-relevant environmental conditions like oxygen deprivation.SIGNIFICANCEAbnormal red blood cell adhesion to the walls of blood vessels is a central feature of sickle cell disease. We study this adhesion by experimentally measuring how long on average red blood cells adhere to a protein-covered surface, and how the strength of the cell-protein bond depends on the force resulting from the surrounding fluid flow. The results vary widely from patient to patient, with some cases showing an unusual regime where the mean bond strength increases with force. We connect these measurements to clinical aspects of the disease, which may aid in the design of individualized therapies in the future.
Cardiac Events Following JYNNEOS Vaccination for Prevention of Monkeypox
Authors: Sharff Katie A , Tandy Thomas K , Lewis Paul F , Johnson Eric S 
Published: November 2022

AbstractPurposeThe JYNNEOS vaccine is an FDA-approved vaccine indicated for prevention of smallpox and monkeypox that is currently being distributed to high-risk individuals to combat the monkeypox public health emergency. The FDA safety data for JYNNEOS vaccine notes potential cardiac adverse events of special interest (AESI) following vaccination. The Advisory Committee on Immunization Practices (ACIP) stated that people with underlying heart disease or three or more major cardiac risk factors should be counseled about the theoretical risk for myopericarditis following vaccination with JYNNEOS. Our objective was to describe the incidence of cardiac AESIs in the Kaiser Permanente Northwest (KPNW) population who received a JYNNEOS vaccination for prevention of monkeypox.MethodsWe conducted a retrospective cohort study of 2,126 KPNW patients aged 12 or older who were vaccinated with at least 1 dose of JYNNEOS vaccine between July 14th2022 and October 10th2022. We searched KPNW databases, including the electronic health record (EHR), for diagnoses of elevated troponins, chest pain, myocarditis, pericarditis, myopericarditis, acute myocardial infarction, cardiac dysrhythmia, cardiac arrest, or ventricular fibrillation that were documented during any encounter (visit) using ICD-10-CM diagnosis codes. Two KPNW physicians reviewed all possible cases in the EHR to adjudicate cases as cardiac AESIs in alignment with the case definition used in the FDA safety data.ResultsThere were 2,126 KPNW members who received a total of 3,235 JYNNEOS vaccine doses between July 14thand October 10th. Encounter ICD10 diagnosis codes and troponin values identified 24 possible cardiac AESI cases. After physician adjudication, there were 10 confirmed cardiac AESI for an incidence of 3.1 per 1000 doses given with (exact 95% CI, 1.5 to 5.7). Of these 10 events, none could be attributed directly to the vaccination.ConclusionThe incidence of cardiac adverse events following JYNNEOS vaccination for prevention of monkeypox is unknown and this is the first study to evaluate cardiac AESI following JYNNEOS vaccination in the 2022 monkeypox public health emergency. This retrospective cohort study of JYNNEOS vaccination for prevention of monkeypox identified 10 cardiac events that all had alternative explanations; and no hospitalizations or serious adverse outcomes were attributed to vaccination. This initial study provides timely information for the clinician counseling their patient with underlying cardiac risk factors on the low observed risk of cardiac events with JYNNEOS vaccination during the 2022 monkeypox public health emergency.
Taurine, a non-proteinous essential amino acid for human body systems: an overview
Authors: Rais Nadeem , Ved Akash , Shadab Mohd. , Ahmad Rizwan , Shahid Mohammad 
Published: November 2022

PurposeTaurine (2-aminoethane sulfonic acid; C2H7NO3S) is a nonprotein sulfur-containing β-amino acid present in nearly all mammalian tissues and the most ubiquitous free endogenous biomolecule in human cells. Taurine is commonly known as a conditionally essential amino acid because taurine is one of the few amino acids that are not incorporated in protein synthesis. The purpose of this study is to review the existing articles related to taurine and to give an account how useful is taurine to the different body systems. In this thorough overview, taurine is covered in terms of its essentiality, sources, advantages for neonates and the elderly, the effects of taurine deficiency, and the safety and toxicity of taurine supplements.Design/methodology/approachThis is a narrative review into the subject matter. Published articles were searched on different portals like PubMed, EMBASE, Scopus, Google Scholar, PubChem etc. The authors also evaluated the availability of taurine in commercially available energy drinks.FindingsThis comprehensive review, presents the potential clinical benefits and functional properties of taurine as a conditionally essential amino acid. Energy drinks containing taurine (and their concentration) are also reported in this review.Originality/valueThis is the first data that the authors are aware of that shows taurine content in a variety of energy drinks on the market.
The influences of telecommunication technology and gender differences on private savings in the Asia–Pacific region
Authors: Tang Chor Foon , Abosedra Salah 
Published: November 2022

PurposeThe purpose of this study is to examine empirically the impacts of gender differences, telecommunication technology (ICT) and other determinants on private savings in 28 selected Asia–Pacific countries.Design/methodology/approachThis study employs the panel data from 2010 to 2017 across 28 selected Asia–Pacific countries. To enhance robustness and address the possibility of endogeneity issue, the present study utilises the fixed effect instrumental variable (IV) estimator to estimate the private savings model for Asia–Pacific region.FindingsThe present study finds that private savings is positively related to disposable income and ICT, but it is negatively associated with the degree of dependency. However, the association between interest rates and private savings are inconclusive as both positive substitution and negative income effects on private savings were observed. Moreover, the results also indicate that working females tend to save less than working males and that of the educated female, despite their impacts are varied across educational attainment levels.Originality/valueThis study provides a novel insight into private savings patterns by focussing upon the gender differences and ICT aspects. In stark contrast to previous literature on the issue, the authors find that working and educated females negatively impact private savings in Asia–Pacific economies due to income inequality and consumption habits. However, the results show that ICT accelerates private savings as it provides easy access to financial services and the requisite frameworks, such as e-business platforms, for generating passive income as well as provide the modalities for more cost-efficient shopping such as price and product comparison frames that yield costs savings which can then be potentially channelled into private savings.
Creating discursive channels: generating and disseminating impactful research insights into the strategic sales enablement of retail technology
Authors: Montecchi Matteo , Bonetti Francesca , Plangger Kirk , Schau Hope Jensen 
Published: November 2022

Purpose
To meet the complex technology needs of retail clients, technology providers must work in a close partnership with their clients and co-envisage a strategic vision for the role that technology should play in the client’s value chain. However, many providers lack the sales capabilities needed to do this. This study aims to examine the need for providers to transition from transaction-oriented to solution selling-oriented approaches. To do so, this study explores the impact outcomes of a knowledge-exchange intervention co-designed with a partner from industry.

Design/methodology/approach
Building on empirical insights from an ongoing research programme that examines retail technology implementations, this study developed a knowledge exchange intervention consisting of planning discursive channels, co-defining the scope, co-developing knowledge, executing the intervention and assessing impact outcomes. Discursive channels – multi-lateral communication channels that allow researchers to work collaboratively with the research partner and other stakeholders – emerge as a critical knowledge-exchange mechanism to generate impact outcomes.

Findings
The knowledge-exchange intervention provides impact by enabling the industry partner to establish cross-functional solutions teams, assess retail clients’ technological needs, aid decision-making, define barriers to implementation and develop a coaching approach to support clients’ technological investments. Impact outcomes vary in magnitude, intensity, scope and duration and can also be unintentional where unplanned changes are embedded into practice.

Originality/value
This impact framework offers a roadmap to orchestrate impact outcomes that emerge from academic enquiries.
Fabric modeling based on Riemann zero curvature
Authors: Hu Xinrong , Li Shuangshuang , Peng Tao , Dong Shi , Zhang Junjie , Chen Changnian , Zhang Zlli , Cui Shuqin , He Ruhan , Li Min , Liu Junping 
Published: November 2022

PurposeFabric has complicated anisotropic mechanical behavior because of the woven pattern and complex physical properties. However, most current fabric simulation models are not satisfied because the models are usually geometrical models with stiffness parameters.Design/methodology/approachIn this paper, the authors present a modeling technique to simulate fabric with Riemann manifold. The proposed nonlinear model is formed with ridge wave-curved surface based on the Riemann zero curvature, and the authors develop a solution to conserve the surface area. It decomposes the m × n matrix constituting the fabric into several batches and processes the fabric dots in batches. In this model, the distance between any two adjacent particles of the fabric's is assumed to be equal, and the area of the curved surface is always constant, and the inclination and decay of the ridge wave-curved surface are also considered.FindingsAs the result, the simulated shape is lifelike. In time cost performance, the model improves the efficiency of the fabric styling and meets the requirements of real-time simulation.Originality/valueThe proposed nonlinear model is formed with ridge wave-curved surface based on the Riemann zero curvature, and the authors develop a solution to conserve the surface area.
Embracing change in tandem: resilience and sustainability together transforming supply chains
Authors: Silva Minelle E. , Pereira Michele M.O. , Hendry Linda Caroline 
Published: November 2022

PurposeThis article investigates how micro-foundations of sustainability can build supply chain resilience (SCRes). Specifically, by defining supply chains as social-ecological systems, this article explores how sustainability as a supplier capability leads to the transformative development of SCRes capabilities.Design/methodology/approachLongitudinal multi-case studies were developed over the first year of the COVID-19 outbreak. A total of 52 interviews were conducted with managers and employees of 12 global supplier firms as well as associated local cooperative and consultancy managers. Secondary data were also used for triangulation. An inductive approach was used for data analysis to elaborate theory through a metaphor.FindingsNine micro-foundations of sustainability were identified and categorised using the dynamic capabilities steps: sensing, seizing and reconfiguring. They were found to move together with the preparing, responding and transforming steps of SCRes, respectively, and thus to perform as dance partners using our dance performance metaphor. Moreover, ten supplier cases were found to be adopting a transformative social-ecological perspective as they performed all key stages of our dance performance metaphor. The transformations all resulted from either institutional or social sustainability, and the associated micro-foundations generated six main SCRes capabilities, most commonly linking visibility and organisation with institutional and social sustainability respectively.Practical implicationsA deeper understanding of sustainability micro-foundations is provided for supply chain managers to enhance the development of SCRes strategies in preparation for future sustainability-related crises.Originality/valueUnlike previous research, this article explores an intertwined understanding of SCRes and sustainability during a crisis. Through the micro-foundations of sustainability we explain how sustainability capability builds transformative SCRes using a supplier perspective.
Exploration and prioritization of enablers to organization work–family balance planning for working sole Indian mothers integrating fuzzy Delphi and AHP
Authors: Kushwaha Jyoti , Sharma Aparna , Singh Pankaj 
Published: November 2022

PurposeThis study intends to identify, prioritize and rank the enablers for organizational work–family balance (WFB) planning specifically for working sole mothers by employing the fuzzy Delphi and analytical hierarchy process (AHP) method.Design/methodology/approachThis paper utilizes the integrated methodology in two steps. Initially, a broad literature review and the fuzzy Delphi method have been utilized to recognize and validate the key WFB enablers. Afterward, the AHP approach has been applied to prioritize and detect the relative importance and rank of identified WFB enablers.FindingsThis paper has identified 9 WFB sub-enablers for working sole mothers under work, family and personal enablers. The work enablers obtain the first rank based on the highest importance weight followed by personal and family enablers. The findings indicate the top five sub-enablers: organizational work–family culture, work from arrangements, emotional intelligence, flexible work schedule and family support.Research limitations/implicationsThe findings offer prioritized areas of concern to the human resource managers and administrators to manage these WFB enablers as per their priority in the direction to formulate the organizational WFB policy-planning specifically for sole mothers.Social implicationsThe prioritized WFB enablers amongst working sole mothers may help sole mothers to manage their social, family and work-related roles in a more effective manner.Originality/valueBased on the best of the authors' considerations, this study firstly incorporates the fuzzy Delphi-AHP method to prioritize and rank the WFB enablers to organizational WFB planning for sole mothers.
Resilience as a protective factor against elder abuse by family caregivers: findings from a cross-sectional study in Hong Kong
Authors: Yan Elsie , Ng Haze K.L. , Sun Rongwei , Lai Daniel W.L. , Cheng Sheung-Tak , Lou Vivian W.Q. , Fong Daniel Y.T. , Kwok Timothy 
Published: November 2022

PurposeThis study aims to explore the risk and protective factors of abuse on older adults by family caregivers, with a special focus on the protective role of caregiver resilience in elder abuse.Design/methodology/approachThis cross-sectional survey was conducted on a purposive sample of 600 family caregivers of community-dwelling older adults in Hong Kong (mean age = 71.04 and female = 67.2%). Caregivers reported in a guided interview about elder abuse behaviours, caregiver burden, care recipients’ agitated behaviours, caregiver resilience, self-efficacy, social support and basic demographic characteristics. Hierarchical linear regression analyses were conducted to examine the predictors of different forms of elder abuse.FindingsCaregiver resilience was predictive of lower levels of verbal abuse, physical abuse, injury and financial exploitation but not potentially harmful behaviour (PHB). Social support was independent with all forms of elder abuse, while self-efficacy predicted greater physical abuse after the adjustment of confounding variables. Caregiver burden and agitated behaviours by care recipients remained as significant risk factors in the final models when protective factors were considered.Research limitations/implicationsThis study extends current knowledge on the protecting role of resilience in elder abuse in family caregiving. Mixed findings revealed on social support and self-efficacy also highlight the complexity of the prediction of caregiver abuse. Further research should address this area.Practical implicationsThe findings of this study warrant the inclusion of caregiver resilience as a key component in developing interventions to prevent elder abuse. Addressing caregiver burden and agitated behaviours have the potential in preventing elder abuse.Social implicationsThe findings raise awareness of the importance of supporting caregivers in the community to prevent elder abuse.Originality/valueResearch concerning the protective factors of elder abuse is in a preliminary stage. To the best of the authors’ knowledge, this study is among the first which successfully demonstrates the protective role of resilience in caregiver abuse on older adults. The findings shed invaluable light on the design of effective interventions.
The consequences of government measures in Palestine to mitigate the impact of COVID-19 on gender-based violence
Authors: Al-Rantisi Ahmed Mohammed , Faraj Ola Usama 
Published: November 2022

Purpose
In the face of the COVID-19 pandemic, many countries, including Palestine, implemented lockdown rules. These measures slowed the outbreak of the coronavirus, and because of the poor management of the Palestinian government in dealing with women’s rights in light of the Corona pandemic, they contributed to increasing gender-based violence (GBV).

Design/methodology/approach
The study used the qualitative method. An inductive thematic latent content analysis was applied using the MAXQDA 2020 program throughout the data collection stage. The content analysis in this study focused on interviews made with the survivors. The interview schedule consisted of four questions covering different aspects of knowledge around GBV during COVID-19 in the Gaza Strip. In-depth interviews were conducted in Arabic with 25 survivors who experienced GBV between January 17 and March 13, 2022.

Findings
The results show that the kind of violence the survivors were most subjected to is psychological violence, followed by economic violence, and the least kind of violence that the survivors were subjected to was sexual violence. The study revealed the good practices for preventing and combating violence against Palestinian women and girls due to government measures to reduce COVID-19 from the perspective of survivors.

Research limitations/implications
One of the limitations of this study was the small number of cases coming to the Aisha Association for support. Because of the temporary suspension of psychological and social support projects from the foundation due to a problem related to funding, some survivors also fear that their husbands will discover that they have participated in the study, so they hesitate to agree to an interview. Survivors’ lack of understanding of the study question related to implications of closing social justice institutions due to COVID-19 on GBV? This led to conflicting answers.

Originality/value
To the best of the authors’ knowledge, it is the first study in Palestine that dealt Consequences of Government Measures in Palestine to Mitigate COVID-19 on GBV, and its results will be important for the protection of survivors and the adoption of government policies in Palestine.
Jurors’ judgements of an autistic defendant are influenced by awareness of autism, knowledge of psychological conditions and trait-empathy
Authors: Blackhurst Tiegan , Hartley Calum , Turner Polly , Warmelink Lara 
Published: November 2022

Purpose
This study aims to investigate whether awareness of an ASD diagnostic label, knowledge of psychological conditions, and trait-empathy influence mock-jurors’ judgements of an autistic defendant. Some autistic adults have an increased risk of acting illegally and standing trial as a defendant because of their behavioural and cognitive characteristics. In court, they may display behaviours stereotypically perceived by jurors as indicators of guilt (e.g. averted gaze), potentially resulting in negative judgements. However, if autistic defendants disclose their condition, this may positively influence jurors’ judgements by offering an alternative explanation for their behaviour. This effect may be stronger in jurors who are highly knowledgeable about psychological conditions and empathic.

Design/methodology/approach
Non-autistic participants (N = 328; M age = 28.21) read a scenario about a defendant’s crime and courtroom behaviour before judging their character and reporting how empathic they felt towards the defendant. Participants were then informed that the defendant was autistic and provided with information about autism before re-evaluating the defendant. Participants’ empathy and knowledge of psychological conditions, including autism, were measured.

Findings
Participants judged the defendant to be more honest and less blameworthy post-label. Trait empathy was positively associated with honesty ratings and higher levels of self-reported empathy. Overall knowledge was negatively associated with ratings for defendant blameworthiness and likeability. Overall, the findings suggest that autistic defendants may benefit from disclosing their diagnosis as this may result in more favourable juror judgements.

Originality/value
To the best of the authors’ knowledge, this study is the first to consider how jurors’ overall knowledge of psychological conditions and trait-empathy may influence judgements of an autistic defendant.