bluuebunny/crossref_metadata_2025_split huggingface dataset:
The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ+CD8αα+ intestinal intraepithelial lymphocytes
Authors: Zhang Haohao , Hu Yiming , Liu Dandan , Liu Zhi , Xie Ningxia , Liu Sanhong , Zhang Jie , Jiang Yuhang , Li Cuifeng , Wang Qi , Chen Xi , Ye Deji , Sun Donglin , Zhai Yujia , Yan Xinhui , Liu Yongzhong , Chen Charlie Degui , Huang Xingxu , Eugene Chin Y. , Shi Yufang , Wu Baojin , Zhang Xiaoren 
Published: January 2022

AbstractIntestinal intraepithelial lymphocytes (IELs) are distributed along the length of the intestine and are considered the frontline of immune surveillance. The precise molecular mechanisms, especially epigenetic regulation, of their development and function are poorly understood. The trimethylation of histone 3 at lysine 27 (H3K27Me3) is a kind of histone modifications and associated with gene repression. Kdm6b is an epigenetic enzyme responsible for the demethylation of H3K27Me3 and thus promotes gene expression. Here we identified Kdm6b as an important intracellular regulator of small intestinal IELs. Mice genetically deficient for Kdm6b showed greatly reduced numbers of TCRαβ+CD8αα+ IELs. In the absence of Kdm6b, TCRαβ+CD8αα+ IELs exhibited increased apoptosis, disturbed maturation and a compromised capability to lyse target cells. Both IL-15 and Kdm6b-mediated demethylation of histone 3 at lysine 27 are responsible for the maturation of TCRαβ+CD8αα+ IELs through upregulating the expression of Gzmb and Fasl. In addition, Kdm6b also regulates the expression of the gut-homing molecule CCR9 by controlling H3K27Me3 level at its promoter. However, Kdm6b is dispensable for the reactivity of thymic precursors of TCRαβ+CD8αα+ IELs (IELPs) to IL-15 and TGF-β. In conclusion, we showed that Kdm6b plays critical roles in the maturation and cytotoxic function of small intestinal TCRαβ+CD8αα+ IELs.
Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes
Authors: Yoon Seongmin , Bogdanov Konstantin , Wallach David 
Published: January 2022

AbstractPhosphorylation of the pseudokinase mixed lineage kinase domain-like protein (MLKL) by the protein kinase RIPK3 targets MLKL to the cell membrane, where it triggers necroptotic cell death. We report that conjugation of K63-linked polyubiquitin chains to distinct lysine residues in the N-terminal HeLo domain of phosphorylated MLKL (facilitated by the ubiquitin ligase ITCH that binds MLKL via a WW domain) targets MLKL instead to endosomes. This results in the release of phosphorylated MLKL within extracellular vesicles. It also prompts enhanced endosomal trafficking of intracellular bacteria such as Listeria monocytogenes and Yersinia enterocolitica to the lysosomes, resulting in decreased bacterial yield. Thus, MLKL can be directed by specific covalent modifications to differing subcellular sites, whence it signals either for cell death or for non-deadly defense mechanisms.
Optimal scheduling of reconfigurable microgrids incorporating the PEVs and uncertainty effects
Authors: Khorram‐Nia Reza , Bahmani‐Firouzi Bahman , Simab Mohsen 
Published: January 2022

AbstractHere, an intelligent optimization method for optimal switching in reconfigurable microgrids is proposed to reduce the cost of microgrids with the presence of distributed generation resources and electrical vehicles. The suggested model deploys the point estimation to manage the uncertainties in the microgrid. The uncertainties are due to load demand, market price, electric vehicle charging and discharging, wind turbine production capacity and photovoltaic cells. The formulation structure is in the form of a nonlinear and single‐objective problem that minimizes the total microgrid asking price by observing the constraints in the problem. In this research, an improved algorithm is used to solve the optimization problem to advance the performance of the process. The capability and efficiency of the proposed method have been investigated on the IEEE 33‐Bus standard test network and the simulation results have shown that optimal switching can be useful in more fitting power distribution and reduction of microgrid cost with the presence of electric vehicle and various scattered products.
Fault detection and classification on insulated overhead conductors based on MCNN‐LSTM
Authors: Xi Yanhui , Tang Xin , Li Zewen , Shen Yin , Zeng Xiangjun 
Published: January 2022

AbstractInsulated conductors are used widely in overhead power transmission due to the stability and reduced construction space. However, the ordinary protection devices are not able to detect the phase‐to‐ground faults without overcurrent. Insulated overhead conductor (IOC) faults are often accompanied by partial discharge (PD) phenomenon. Thus, PD monitoring and recognition plays an important role in evaluating the condition of insulation degradation or detecting power line faults. This paper presents a new approach based on a multi‐channel CNN‐LSTM (convolutional neural network, long short term memory) network for fault detection by determining whether there is local discharge phenomenon on the IOC, in which the three‐phase voltage signals are processed with FFT to obtain low frequency and high frequency components, and then the two components together with the original three‐phase signals are fed into three parallel CNNs having different filter lengths, and finally LSTM is used to compose those different‐scale features sequentially. Then, the fault types are determined according to the result of fault detection. This proposed method is tested on the ENET public data set with eight types of faults, and simulation results indicate that the method can improve the detection and classification accuracy of IOC faults compared with other classification methods.
Data‐driven optimal scheduling for underground space based integrated hydrogen energy system
Authors: Li Hengyi , Qin Boyu , Jiang Yu , Zhao Yuhang , Shi Wen 
Published: January 2022

AbstractIntegrated hydrogen energy systems (IHESs) have attracted extensive attention in mitigating climate problems. As a kind of large‐scale hydrogen storage device, underground hydrogen storage (UHS) can be introduced into IHES to balance the seasonal energy mismatch, while bringing challenges to optimal operation of IHES due to the complex geological structure and uncertain hydrodynamics. To address this problem, a deep deterministic policy gradient (DDPG)‐based optimal scheduling method for underground space based IHES is proposed. The energy management problem is formulated as a Markov decision process to characterize the interaction between environmental states and policy. Based on DDPG theory, the actor‐critic structure is applied to approximate deterministic policy and actor‐value function. Through policy iteration and actor‐critic network training, the operation of UHS and other energy conversion devices can be adaptively optimised, which is driven by real‐time response data instead of accurate system models. Finally, the effectiveness of the proposed optimal scheduling method and the benefits of underground space are verified through time‐domain simulations.
Individual-based Creatine Kinase Reference Values in Response to
Soccer Match-play
Authors: Ribeiro João , Gantois Petrus , Moreira Vitor , Miranda Francisco , Romano Nuno , Nakamura Fábio Yuzo 
Published: January 2022

AbstractThe aim of the present study was to determine the creatine kinase reference
limits for professional soccer players based on their own normal post-match
response. The creatine kinase concentration was analyzed in response to official
matches in 25 players throughout a 3-year period. Samples were obtained between
36–43 hours following 70 professional soccer matches and
corresponded to 19.1±12.1 [range: 6–49] samples per player.
Absolute reference limits were calculated as 2.5th and
97.5th percentile of the samples collected. Creatine kinase
values were also represented as a percentage change from the
individual’s season mean and represented by 90th,
95th and 97.5th percentiles. The absolute reference
limits for creatine kinase concentration calculated as 97.5th and
2.5th percentiles were 1480 U.L−1 and
115.8 U.L−1, respectively. The percentage change
from the individual’s season mean was 97.45±35.92% and
players were in the 90th, 95th and 97.5th
percentiles when the percentages of these differences were 50.01, 66.7, and
71.34% higher than player’s season mean response, respectively.
The data allowed us to determine whether the creatine kinase response is typical
or if it is indicative of a higher than normal creatine kinase elevation and
could be used as a practical guide for detection of muscle overload, following
professional soccer match-play.
The Reliability of the African Neuropsychology Battery in Persons of African Descent
Authors: Ikanga Jean , Basterfield Candice , Taiwo Zinat , Bragg Princess , Bartlett Alexandria , Howard Christopher , Robert Spencer , Stringer Anthony Y 
Published: January 2022

AbstractObjectiveThe African Neuropsychology Battery (ANB) includes eight culturally appropriate cognitive tests developed for use in the Congo and other sub-Saharan African populations. The current study examines the reliability of the ANB in three samples of participants of African descent.MethodsSubjects were recruited in the United States and the Congo to participate in three studies of ANB internal consistency reliability (Study 1), test–retest reliability (Study 2), and interrater reliability for the two ANB measures (i.e., Visuospatial Memory and Proverb Tests) requiring examiner ratings of response adequacy (Study 3). Subjects were administered ANB tests of visuospatial perception, language, memory, abstract reasoning, and problem solving. We calculated Cronbach’s alpha, corrected item-total correlations and mean inter-item correlations for internal consistency, Pearson product–moment correlations and intraclass correlation coefficients for test–retest reliability, and intraclass correlation coefficients for interrater reliability.ResultsThe ANB tests had acceptable internal consistency (Cronbach’s alphas ranging from .37 to .93). Across subtests, test–retest reliability coefficients ranged from .39 to .91, and intraclass correlation stability coefficients (ICCs) ranged from .39 to .82. Of the two ANB tests requiring interrater reliability, only the Proverb Test had a low ICC of .13, (confidence intervals: −.29 to .52).ConclusionThe present study demonstrated that most ANB tests show adequate reliability in participants of African descent. However, the scoring criteria of the African Proverb Test require revision in order to improve the interrater reliability of the measure.
A data-adaptive Bayesian regression approach for polygenic risk prediction
Authors: Song Shuang , Hou Lin , Liu Jun S 
Published: January 2022

AbstractMotivationPolygenic risk score (PRS) has been widely exploited for genetic risk prediction due to its accuracy and conceptual simplicity. We introduce a unified Bayesian regression framework, NeuPred, for PRS construction, which accommodates varying genetic architectures and improves overall prediction accuracy for complex diseases by allowing for a wide class of prior choices. To take full advantage of the framework, we propose a summary-statistics-based cross-validation strategy to automatically select suitable chromosome-level priors, which demonstrates a striking variability of the prior preference of each chromosome, for the same complex disease, and further significantly improves the prediction accuracy.ResultsSimulation studies and real data applications with seven disease datasets from the Wellcome Trust Case Control Consortium cohort and eight groups of large-scale genome-wide association studies demonstrate that NeuPred achieves substantial and consistent improvements in terms of predictive r2 over existing methods. In addition, NeuPred has similar or advantageous computational efficiency compared with the state-of-the-art Bayesian methods.Availability and implementationThe R package implementing NeuPred is available at https://github.com/shuangsong0110/NeuPred.Supplementary informationSupplementary data are available at Bioinformatics online.
A systematic review, meta-analysis, and meta-regression of patient education for secondary prevention in patients with coronary heart disease: impact on psychological outcomes
Authors: Shi Wendan , Ghisi Gabriela L M , Zhang Ling , Hyun Karice , Pakosh Maureen , Gallagher Robyn 
Published: January 2022

Abstract

Background
Patient education is a cardiac rehabilitation core component and is associated with improvements in self-management of patients with coronary heart disease (CHD). However, the efficacy of such interventions on psychosocial outcomes and relative impact of duration is less clear.

Objectives
This study aimed to assess the efficacy of patient education for secondary prevention related to behaviour change and risk factor modification on psychological outcomes in CHD patients.

Design
A systematic review and meta-analysis.

Data sources
PsycINFO, CINAHL, Embase, EmCare, MEDLINE, PubMed, and the Cochrane Central Register of Controlled Trials were searched from inception to February 2021.

Eligibility criteria for study selection
Randomized controlled trials (RCTs) evaluating patient education in CHD patients, or following myocardial infarction, or revascularization compared with usual care were identified. Outcomes included depression and anxiety at &lt;6 and 6–12 months of follow-up.

Results
A total of 39 RCTs and 8748 participants were included. Patient education significantly improved participants’ depressive symptoms at &lt;6 (SMD −0.82) and 6–12 months (SMD −0.38) of follow-up and anxiety level at &lt;6 (SMD −0.90), and 6–12 months (SMD −0.32) of follow-up. Patient education also reduced the risk for having clinical depression by 35% and anxiety by 60%. Longer patient education of ≥3 months, resulted in more improvement in depressive symptoms at 6–12 months (coefficient −0.210) compared to shorter duration.

Conclusions
Patient education for secondary prevention reduces anxiety and depressive symptoms in CHD patients. Regardless of intensity, longer patient education improves depression more than short duration. More information is needed on the relative impact of other intervention components.

Data registration
PROSPERO (CRD42020200504).
Applying multidate Sentinel-2 data for forest-type classification in complex broadleaf forest stands
Authors: Shirazinejad Golsa , Javad Valadan Zoej Mohammad , Latifi Hooman 
Published: January 2022

AbstractBiodiversity assessment and forest management require accurate tree species maps, which can be provided by remote sensing. Whereas the application of high-spatial resolution remote sensing data is constrained by high costs, Sentinel-2 (S2) satellites provide free imagery with appropriate spatial, spectral and temporal resolutions for mapping of various forest traits across larger spatial scales. Here we assessed the potential of multidate S2 as well as a Digital Elevation Model (DEM) in classifying tree species across a highly structured and heterogeneous broadleaf forest ecosystem in the Hyrcanian zone of northern Iran. We applied multidate S2 and DEM data as input to a variable selection using random forests algorithm for feature reduction. Ten forest types were classified using random forest algorithm and to evaluate the results we computed area-adjusted confusion matrices. Classifications based on single-date S2 data reached overall accuracies of 67–74 per cent, whereas results for multidate S2 images increased the accuracy by ~28 per cent. Joint use of DEM data along with multidate S2 images showed improvement of overall accuracy by ~3 per cent. In addition, we studied the effect of topographic correction of S2 data on classification performance. The results imply that applying topographically corrected imagery had no significant effect on the classification accuracy. Our results demonstrate the high potential of freely available multisource remotely sensed data for broadleaf tree species classification across complex broad-leaved forest landscapes.
Mechanisms of sex determination and X-chromosome dosage compensation
Authors: Meyer Barbara J 
Published: January 2022

Abstract
Abnormalities in chromosome number have the potential to disrupt the balance of gene expression and thereby decrease organismal fitness and viability. Such abnormalities occur in most solid tumors and also cause severe developmental defects and spontaneous abortions. In contrast to the imbalances in chromosome dose that cause pathologies, the difference in X-chromosome dose used to determine sexual fate across diverse species is well tolerated. Dosage compensation mechanisms have evolved in such species to balance X-chromosome gene expression between the sexes, allowing them to tolerate the difference in X-chromosome dose. This review analyzes the chromosome counting mechanism that tallies X-chromosome number to determine sex (XO male and XX hermaphrodite) in the nematode Caenorhabditis elegans and the associated dosage compensation mechanism that balances X-chromosome gene expression between the sexes. Dissecting the molecular mechanisms underlying X-chromosome counting has revealed how small quantitative differences in intracellular signals can be translated into dramatically different fates. Dissecting the process of X-chromosome dosage compensation has revealed the interplay between chromatin modification and chromosome structure in regulating gene expression over vast chromosomal territories.
Utilization, Contributions, and Perceptions of Paid Home Care Workers Among Households in New York State
Authors: Sterling Madeline R , Ringel Joanna Bryan , Cho Jacklyn , Riffin Catherine A , Avgar Ariel C 
Published: January 2022

Abstract

Background and Objectives
While family caregivers have traditionally provided care for older adults with chronic conditions and disabilities, the demand for paid home care workers has increased in the last decade. Although typically thought to assist with personal care, emerging data suggest that paid home care workers assist with a wider scope of care. However, the extent and quality of the care they deliver remains poorly understood.

Research Design and Methods
Using the Empire State Poll, a telephone-based cross-sectional survey of 800 adults in New York State, we characterized the types of care that paid home care workers provided and the perceived value of that care.

Results
Of 800 participants surveyed, 274 reported that they or an immediate family member received care from a paid home care worker (34.3%). Of these, the majority (73.9%) reported that paid home care workers provided emotional and/or medical care, in addition to personal care. In adjusted models, providing emotional and medical care (compared to personal care alone) was associated with nearly a twofold greater perception of importance and experience by the care recipients.

Discussion and Implications
Our findings provide additional data on how paid home care workers contribute to patient care, from the perspective of the care recipient(s). The type of care provided is associated with varying magnitudes of perceived quality. Although limited to New York, these findings have implications for paid home care workers’ training and compensation. Future studies are warranted to investigate the specific factors that mediate the association between types of care provided and their perceived value.
Evaluation of marketing authorization and clinical implementation of ulipristal acetate for uterine fibroids
Authors: Middelkoop Mei-An , de Lange Maria E , Clark T Justin , Mol Ben Willem J , Bet Pierre M , Huirne Judith A F , Hehenkamp Wouter J K 
Published: January 2022

ABSTRACT
Ulipristal acetate (UPA) is a medical treatment for uterine fibroids and was authorized for surgical pre-treatment in 2012 after the conduct of the PEARL I and II randomized controlled trials and for intermittent treatment after the observational PEARL III and IV trials. However, UPA came into disrepute due to its temporary suspension in 2017 and 2020 because of an apparent association with liver injury. This clinical opinion paper aims to review the process of marketing authorization and implementation of UPA, in order to provide all involved stakeholders with recommendations for the introduction of future drugs. Before marketing authorization, the European Medicines Agency (EMA) states that Phase III registration trials should evaluate relevant outcomes in a representative population, while comparing to gold-standard treatment. This review shows that the representativeness of the study populations in all PEARL trials was limited, surgical outcomes were not evaluated and intermittent treatment was assessed without comparative groups. Implementation into clinical practice was extensive, with 900 000 prescribed treatment cycles in 5 years in Europe and Canada combined. Extremely high costs are involved in developing and evaluating pre-marketing studies in new drugs, influencing trial design and relevance of chosen outcomes, thereby impeding clinical applicability. It is vitally important that the marketing implementation after authorization is regulated in such way that necessary evidence is generated before widespread prescription of a new drug. All stakeholders, from pharmaceutical companies to authorizing bodies, governmental funding bodies and medical professionals should be aware of their role and take responsibility for their part in this process.
Systematic Revision of a New Butterfly Genus,CisandinaNakahara & Espeland, n. gen., with Descriptions of Three New Taxa (Lepidoptera: Nymphalidae: Satyrinae)
Authors: Nakahara Shinichi , Rodríguez-Melgarejo Maryzender , Kleckner Kaylin , Corahua-Espinoza Thalia , Tejeira Rafael , Espeland Marianne , Casagrande Mirna M , Barbosa Eduardo P , See Joseph , Gallice Geoffrey , Lamas Gerardo , Willmott Keith R 
Published: January 2022

AbstractWe here establish a new genus in the nymphalid butterfly subtribe Euptychiina, Cisandina Nakahara & Espeland, n. gen. to harbor five species hitherto placed within two polyphyletic genera, namely Magneuptychia Forster, 1964 and Euptychoides Forster, 1964. We compiled data from over 350 specimens in 17 public and private collections, as well as DNA sequence data for all relevant species, to revise the species-level classification of this new genus. According to our multi-locus molecular phylogeny estimated with the maximum likelihood approach, Cisandina lean. comb., Cisandina philippan. comb. & reinst. stat., Cisandina fidan. comb., Cisandina sanmarcosn. comb., and Cisandina trinitensisn. comb. are proposed as new taxonomic combinations, since these species are distantly related to the type species of Magneuptychia and Euptychoides and cannot reasonably be accommodated in any other genus. Lectotypes are designated for Papilio lea Cramer, 1777, Papilio junia Cramer, 1780, Euptychia philippa Butler, 1867, and Eupytchia fida Weymer, 1911. Two new species of Cisandinan. gen. are named and described herein, C. esmeralda Nakahara & Barbosa, n. sp. and C. castanya Lamas & Nakahara, n. sp., increasing the described species diversity of the genus to seven. The immature stages of C. castanyan. sp. and C. philippan. comb. & reinst. stat. are documented along with their natural hostplants, representing the first two species of the genus with known life history information. We describe a new subspecies, Cisandina fida directa Nakahara & Willmott, n. ssp., based on a limited number of specimens from southern Ecuador and central Peru. We were unable to obtain genetic data for the nominate race of C. fidan. comb., and thus, this taxonomic hypothesis is currently based solely on phenotypic characters.