bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preserving the Tangible and Intangible Heritage of Thanjavur - Design of a Cultural “experience” Centre
Authors: M Sona 
Published: June 2022

Abstract
‘Tangible Cultural Heritage’ refers to physical artefacts produced, maintained and transmitted inter-generationally in a society. ‘Intangible Cultural Heritage’ indicates the practices, representations, expressions, knowledge, skills – as well as the instruments, objects, artefacts and cultural spaces associated therewith – that communities, groups and, in some cases, individuals recognize as part of their Cultural Heritage. Being the cradle to many of the arts and crafts in South India, Thanjavur is known for its arts like painting, bronze sculptures, and musical instruments. Manufacture of musical instruments like veena, tampura, violin, mrithangam, thavil and kanjira is another economic activity in the city. There are traces of the Marathi music form, Abhang, owing to the Maratha rule in the area. The study aims at preserving the culture of Thanjavur, by envisioning it as a living entity that interacts with its tourists for a wholesome experience. It focusses on design of a cultural experience centre that integrates the tangible and intangible elements of the cultural heritage of Thanjavur. It attempts to thrust on a sustainable tourism development, and improve the living standards of artisans, integrated with providing a multi-sensory experience of the Thanjavur culture to its tourists. The study includes both the tangible and intangible elements of the cultural heritage of Thanjavur. The most common fine arts and crafts in the context of Thanjavur have been chosen to set the cultural backdrop for the project. Contribution of performing arts is limited to the extent of provision for performance areas only, owing to the floating population of the respective artists. The study is limited to the district of Thanjavur.
Palatal surface development from 6 years of age to early adulthood: data modelling using 3D geometric morphometrics
Authors: Jaklová Lenka Kožejová , Velemínská Jana , Dupej Ján , Moravec Tomáš , Bejdová Šárka 
Published: June 2022

Abstract
Objectives: The study followed the modelling of postnatal growth of a healthy palate of the Central European (Czech) population sample based on transverse data on sex and age from 6 to 19 years. Materials and methods: Digitised 3D models of 212 healthy palatal surfaces were evaluated using 3D geometric morphometrics and superprojections. The individuals were grouped based on age (preschool, younger and older school age, younger and older adolescents, young adults) and sex (♂ n=101, ♀ n=111). Results: Female palatal development was non-linear and was interrupted between the 10–12 years and then proceeded intensively until the age of 15 when it ceased. In contrast, male modelled growth was consistent throughout the follow-up and continued linearly until at least 19 years of age. The palate did not widen further with increasing age, and primarily palatal vaulting and heightening were found. The characteristics and distribution of areas with extensive modelled growth changes were comparable in females and males, as confirmed by the correlation of PC1 and PC2 within modal space and growth trajectories. The extent of sexual dimorphism increased from 15 years of age due to pubertal spurt combined with earlier completion of palatal development in females.Conclusions: The study showed modelled healthy palatal development from 6 years of age to early adulthood, which might be utilised as reference standards for the Central European population sample.Clinical relevance: The comparison of normal reference subjects with patients with cranio-maxillo-facial dysmorphologies represents the first step in diagnosing and establishing effective therapy.
Gray level co-occurrence matrix and wavelet analyses reveal discrete changes in proximal tubule cell nuclei after mild acute kidney injury
Authors: Pantic Igor , Cumic Jelena , Dugalic Stefan , Petroianu Georg A. , Corridon Peter R. 
Published: June 2022

Abstract
Acute kidney injury relates to an abrupt reduction in renal function resulting from numerous conditions. Morbidity, mortality, and treatment costs related to AKI are relatively high. This condition is strongly associated with damage to proximal tubule cells (PTCs), generating distinct patterns of transcriptional and epigenetic alterations that result in structural changes in the nuclei of this epithelium. To this date, AKI-related nuclear chromatin redistribution in PTCs is poorly understood, and it is unclear whether changes in PTC chromatin patterns can be detected using conventional microscopy during mild AKI, which can progress to more debilitating forms of injury. In recent years, gray level co-occurrence matrix (GLCM) analysis and discrete wavelet transform (DWT) have emerged as potentially valuable methods for identifying discrete structural changes in nuclear chromatin architecture that are not visible during the conventional histopathological exam. Here we present findings indicating that GLCM and DWT methods can be successfully used in nephrology to detect subtle morphological alterations associated with mild tissue injury demonstrated in rodents by inducing a mild form of AKI through ischemia-reperfusion injury. This rodent model allowed us to show that pre-renal mild AKI is associated with the significant reduction of textural homogeneity of PTC nuclei, indirectly assessed by GLCM indicators and DWT energy coefficients.
N6-methyladenosine METTL3-induced circMYO1C accelerates the pancreatic ductal adenocarcinoma tumorigenesis through IGF2BP2/VEGFA manner
Authors: Guan Hua , Luo Wei , Li Mingfei 
Published: June 2022

Abstract
Recently, studies on biological functions of circular RNA (circRNA) and N6-methyladenosine (m6A) modification in human cancers have sprung up. Herein, our work reported that a novel m6A-modified circRNA circMYO1C (hsa_circ_0041234) up-regulated in the pancreatic ductal adenocarcinoma (PDAC) and regulated the tumorigenesis of PDAC. Our findings demonstrated that circMYO1C exhibited significantly higher expression in PDAC tissues. Functionally, circMYO1C promoted the proliferation and migration of PDAC ells in vitro and its silencing reduced the tumor growth in vivo. Mechanistically, the cyclization of circMYO1C was mediated by m6A methyltransferase METTL3. Moreover, methylated RNA immunoprecipitation sequencing (MeRIP-seq) unveiled that there was remarkable m6A modification on VEGFA mRNA 3’-UTR. CircMYO1C targeted the m6A modified site of VEGFA mRNA to enhance its stability through cooperating with IGF2BP2. In conclusion, these findings highlight the oncogenic role of METTL3-induced circMYO1C in PDAC tumorigenesis via m6A-dependent RNA-protein interactions, inspiring a novel strategy to explore PDAC epigenetic therapy.
AcornHRD: an HRD algorithm which was highly associated with anthracycline-based neoadjuvant chemotherapy in Chinese breast cancer
Authors: Pan Jia-Ni , Li Pu-Chun , Wang Meng , Li Ming-Wei , Ding Xiao-Wen , Zhou Tao , Wang Hui-Na , Wang Yun-Kai , Chen Li-Bin , Wang Rong , Ye Wei-Wu , Lou Feng , Wang Xiao-Jia , Cao Wen-Ming 
Published: June 2022

Abstract
Background
Homologous recombination deficiency (HRD) can result from BRCA dysfunction and is associated with platinum sensitivity, PARP inhibitor, and other DNA-damaging drugs. There are many commercial HRD detection assays, but there is still no uniform standard in China. This study aimed to develop and validate an HRD scoring algorithm.
Methods
Ninety-six in-house BC samples and 6 HRD positive standard cells were analyzed by whole-genome sequencing (WGS). Besides, 122 BCs from the TCGA database were down-sampled to ~ 1X WGS. We constructed a algorithm named AcornHRD for HRD score based on WGS at low coverage as input data to estimate large-scale copy number alteration (LCNA) events on the genome. The sensitivity and specificity were compared between our algorithm and the ShallowHRD. A clinical cohort of 50 BCs (15 cases carrying BRCA mutation) was used to assess the association between HRD status and anthracyclines-based neoadjuvant treatment outcomes.
Results
A 100kb-window was defined as the optimal size using 41 in-house cases and the TCGA dataset. HRD positive threshold was determined as HRD score ≥ 10 using 55 in-house BCs with BRCA mutation to achieve 95% sensitivity. The sensitivity and specificity of AcornHRD were both 100%, while those of the ShallowHRD were 40% and 100%, respectively. Meanwhile, AcornHRD sensitivity was superior to ShallowHRD (87% vs 13%) in the clinical cohort. BRCA status was significantly associated with HRD status by AcornHRD and ShallowHRD (P = 0.00838 and P = 0.00284, respectively). However, AcornHRD had a higher positive concordance rate than the ShallowHRD algorithm (70% vs 60%). In the clinical cohort of neoadjuvant treatment, the HRD positive group was more likely to respond to anthracycline-based chemotherapy than the HRD negative group, with outcomes of pCR (OR = 9.5, 95% CI: 1.11–81.5, p = 0.04) and residual cancer burden score of 0 or 1 (RCB0/1) (OR = 10.29, 95% CI: 2.02–52.36, p = 0.005). Among 35 patients lacking BRCA mutations, the HRD positive group tended to have RCB0/1 responses compared to the HRD negative group (OR = 6.0, 95% CI: 1.00–35.91, p = 0.05).
Conclusion
Here, we developed a stable algorithm for the HRD score. A promising assay for clinical application to predict the sensitivity of DNA-damaging drugs.
Physiological, Hematological and Biochemical responses in Hararghe-highland Lamb Subjected to Water Salinity Levels of Lake Basaka in a semiarid area of Ethiopia
Authors: Tulu Diriba , Urge Mengistu , Yusuf Yisehak 
Published: June 2022

Abstract
The current study aimed to evaluate the effect of drinking salinity levels in Lake water on the growth performance, physiological, and blood constituents of Hararghe-highland lambs. A total of 28 lambs (average IBW of 18±1.18kg) were categorized into four levels of water salinity, namely freshwater (510mg/l TDS), lake Basaka water (LBW; 2600mg TDS/L); lake Basaka water plus 100% TDS of LBW; 5200mg TDS/L) and lake Basaka water plus 200% TDS of LBW; 7900mg TDS/L). The current results suggest that increased TDS levels in lake water increase the water intake of lambs while not affecting IBW, FBW, AWG, and FCR. Additionally, drinking saline lake with increasing TDS levels increased RT and RR and caused a significant (P<0.05) change in the concentrations of glucose, albumin, urea, triglycerides, sodium, AST, ALT, T3, and T4. Some hematological variables and biochemical constituents like creatinine, total protein, cholesterol, chlorides, potassium, magnesium, and calcium showed no significant (P>0.05) differences. In conclusion, Hararghe-highland lambs from Ethiopia could tolerate lake Basaka water with a high salt level (7952mg/L TDS).
Indoor Air Pollution and Respiratory Function on Primary School Students in West Jakarta, Indonesia
Authors: Mulia Gelora J.T. , Wispriyono Bambang , Kusnoputranto Haryoto , Hartono Budi , Rozaliyani Anna 
Published: June 2022

Background:This study aimed to investigate the relationship between air pollutant exposure,i.e.,Particulate Matter (PM2,5), and the numbers of airborne bacterial colonies inside the classroom to the respiratory symptoms of three primary school children in West Jakarta.Methods:We did a quantitative study with a cross-sectional design using variables,i.e., age, sex, physical activity, nutritional status, students’ density, ventilation, classroom temperature, and classroom humidity. We used Haz-Dust EPAM 5000 to measure PM2,5,MAS 100 NT to calculate the total bacterial colony, spirometry to measure the respiratory capacity, and questionnaire to measure other related variables.Results:We found a significant relationship between PM2,5concentration with respiratory symptoms, however, there was no significant relationship between the total number of airborne bacterial colonies with respiratory symptoms.Conclusion:Based on our results, we conclude that there was a significant relationship between the PM2,5concentration and obstructive pulmonary symptoms and there was no significant relationship between the numbers of the bacterial colonies with pulmonary symptoms.
Standardizing Cranioplasty Outcomes Following Stroke or Traumatic Brain Injury: Protocol for the Development of a Core Outcome Set
Authors: Mee Harry , Castaño-Leon Ana M , Timofeev Ivan , Adeleye Amos , Devi Bhagavatula Indira , Marklund Niklas , Muehlschlegel Susanne , Bond Katie , Clement Clare , Grieve Kirsty , Owen Nicola , Whiting Gemma , Turner Carole , Rubiano Escobar Andres Mariano , Shukla Dhaval , Paul Maria , Allanson Judith , Pomeroy Valerie , Viaroli Edoardo , Warburton Elizabeth , Wells Adam , Hawryluk Gregory , Helmy Adel , Anwar Fahim , Honeybul Stephen , Hutchinson Peter , Kolias Angelos 
Published: June 2022

Background
Core outcome sets (COSs) are important and necessary as they help standardize reporting in research studies. Cranioplasty following traumatic brain injury (TBI) or stroke is becoming increasingly common, leading to an ever-growing clinical and research interest, especially regarding the optimal material, cost-effectiveness, and timing of cranioplasty concerning neurological recovery and complications. Consequently, heterogeneous reporting of outcomes from such diverse studies has led to limited meta-analysis ability and an ongoing risk of outcome reporting bias. This study aims to define a standardized COS for reporting in all future TBI and stroke cranioplasty studies.

Objective
This study has four aims: (1)	undertake a systematic review to collate the most current outcome measures used within the cranioplasty literature; (2) undertake a qualitative study to understand better the views of clinicians, patients' relatives, and allied health professionals regarding clinical outcomes following cranioplasty; (3) undertake a Delphi survey as part of the process of gaining consensus for the COS; and (4) finalize consensus through a consensus meeting resulting in the COS.

Methods
An international steering committee has been formed to guide the development of the COS. In addition, recommendations from other clinical initiatives such as COMET (Core Outcomes and Effectiveness Trials) and OMERACT (Outcome Measures in Rheumatology) have been adhered to. Phase 1 is data collection through a systematic review and qualitative study. Phase 2 is the COS development through a Delphi survey and consensus meetings with consensus definitions decided and agreed upon before the Delphi survey begins to avoid bias.

Results
Phase 1 started at the end of 2019, following ethical approval in December 2019, and the project completion date is planned for the end of 2022 or beginning of 2023.

Conclusions
This study should result in a consensus on a COS for cranioplasty, following TBI or stroke, to help standardize outcome reporting for future studies, which can be applied to future research and clinical services, help align future studies, build an increased understanding of cranioplasty and its impact on a patient’s function and recovery, and help standardize the evidence base.

International Registered Report Identifier (IRRID)
DERR1-10.2196/37442
APPLICATION OF MODEL PROBLEM BASED LEARNING TO IMPROVE STUDENT LEARNING OUTCOMES IN SUBTEMA ENERGY AND ITS CHANGES
Authors: Setiawati Wida , Priatna Dedi , Firdaus Anugrah Ramadhan 
Published: June 2022

This study aims to improve learning outcomes of students through a learning model of problem-based learning on the sub-theme energy and change. This research was conducted in class III SD Muhammadiyah 4 Bandung and against the background circumstances of students are lacking in learning outcomes in the learning because teachers still use the learning that is conventional, that is, by using the lecture method, so that the involvement of learners in the learning was minimal. By using the model of Problem Based Learning can improve learning outcomes of students, because, in this model, the students become the center in the process of learning, stimulating learners to think critically, and to deepen their knowledge about what they know and what they need to know to solve the problem. In addition to its model of problem-based learning can also increase the activity and learning outcomes of students, help, develop skills to solve problems, and develop the skills to communicate orally. The conclusions obtained from this study is that the use of the model of problem-based learning can improve learning outcomes of students. Thus, the application of learning model problem based learning in sub-theme energy and amendments can be used as an alternative method of learning to be applied in Elementary School.
PENERAPAN TEKNIK ROLE PLAYING UNTUK MENINGKATKAN RASA KEPEDULIAN ANTAR SISWA
Authors: Minsyar Marfany , Yusup Salma Namira 
Published: June 2022

Tujuan penulisan artikel ini adalah untuk mengetahui bagaimana penerapan teknik role playing dalam meningkatkan rasa kepedulian antar siswa. Metode penelitian yang digunakan yaitu studi literatur dengan membandingkan antara 2 artikel yang membahas penggunaan teknik role playing dalam menurunkan perilaku bullying. Pengambilan penelitian tersebut dilakukan karena antara perilaku bullying dengan kepedulian yang dimiliki siswa memiliki hubungan yang erat. Hasil penelitian menunjukkan bahwa teknik role playing efektif untuk digunakan dalam peningkatan rasa kepedulian antar siswa. Kata Kunci: Role Playing, Kepedulian Siswa
PENGARUH LAYANAN BIMBINGAN KELOMPOK TERHADAP PERILAKU KEPEMIMPINAN PESERTA DIDIK
Authors: Faridah Fujianti Yuthika , Patimah Siti 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui pengaruh layanan bimbingan kelompok pada perilaku kepemimpinan peserta didik. Penelitian ini dilakukan di Madrasah Aliyah Negeri 1 Majalengka. Desain penelitian yang digunakan adalah penelitian regresional. Populasi dalam penelitian ini terdiri dari 45 siswa OSIS Organisasi Siswa Intra School) melalui Teknik Simple Random Sampling dan Stratified Sampling Technique (Stratified Radom Sampling). Teknik pengumpulan data dilakukan dengan kuesioner. Hasil penelitian ini didapatkan tabel koefisien dengan nilai signifikan 0,000. Setelah dianalisa sesuai dengan hipotesis yang ada bahwa Pvalue ≤ α (0,000 ≤ 0,05 = H0 ditolak) berarti ada pengaruh positif antara layanan bimbingan kelompok terhadap perilaku kepemimpinan peserta didik di Madrasah Aliyah Negeri 1 Majalengka. Selanjutnya, para peneliti melakukan analisis seberapa besar pengaruh layanan bimbingan kelompok pada perilaku kepemimpinan dengan membaca model ringkasan tabel. Tabel ringkasan yang diperoleh menggambarkan nilai korelasi atau hubungan yang sama dengan R = 0,670 dan menjelaskan persentase pengaruh variabel independen terhadap variabel dependen yang disebut koefisien determinasi yang merupakan hasil kuadrat R, dari output yang diperoleh koefisien determinasi sebesar 0,448 berisi pengertian bahwa pengaruh kelompok layanan bimbingan terhadap perilaku kepemimpinan adalah 44,8% sedangkan sisanya dipengaruhi oleh variabel lain. Kata Kunci: Bimbingan Kelompok, Perilaku Kepemimpinan, Peserta Didik.
GANGGUAN KECEMASAN SOSIAL DENGAN MENGGUNAKAN TEKNIK RASIONAL EMOTIF TERAPI
Authors: Oktapiani Nia , Putri P Amelia 
Published: June 2022

Artikel ini bertujuan untuk memaparkan kajian tentang pengaruh konseling REBT dalam mengatasi kecemasan. Kecemasan dapat terjadi pada setiap individu. Seseorang yang menderita kecmasan selalu merasa khawatir dan selalu bereaksi berlebihan. keluhan fisik yang biasanya terjadi antara lain adalah tidak tenang, tidur terganggu, kelelahan, sakit kepala, tangan gemetar, dan jantung yang berdebar-debar. Individu terus menerus mengkhawatirkan segala macam masalah yang berlebihan menjadi sangat penting. kecemasan dilatar belakangi oleh pemikiran irasional cenderung menimbulkan gangguan. Konseling REBT adalah suatu pendekatan konseling yang menangani masalh-masalah yang berhubungan dengan emosi, kognisi, dan tingkah laku, dengan mengubah cara pandang klien yang irasional dan tidak logis agar klien dapat mengembangkan dirinya. Kata Kunci: Rasional Emotive Behaviour Therapy (REBT), Kecemasan
PENGARUH LAYANAN BIMBINGAN BELAJAR TERHADAP MOTIVASI BELAJAR SISWA KELAS IX SMPN 2 KADUNGORA
Authors: Katerina Ina , Mustika R.Ika , Supriatna Ecep 
Published: June 2022

Penelitian ini bertujuan untuk mengetahui ada tidaknya pengaruh layanan bimbingan belajar terhadap motivasi belajar siswa kelas IX SMPN 2 Kadungora. Metode penelitian yang digunakan adalah pre-eksperimen desain one group pretest posttest Polulasi dalam penelitian ini adalah seluruh siswa kelas IX SMPN 2 Kadungora. Melalui teknik probabilitas sampling ditentukan sampel penelitian sejumlah 52 orang. Alat pengumpul data dalam penelitian ini menggunakan angket motivasi belajar dan lembar observasi. Data yang terkumpul dianalisis menggunakan SPSS 22 untuk diuji paired sample t-test. Berdasarkan skor pretest posttest diketahui rata-rata motivasi belajar siswa setelah dilakukan layanan bimbingan belajar mengalami peningkatan. Terdapat pengaruh signifikan dari layanan belajar terhadap motivasi belajar siswa kelas IX SMPN 2 Kadungora ( p=0,00). Kata Kunci: Motivasi belajar, layanan bimbingan belajar.
EFEKTIVITAS TEKNIK SELF-MANAGEMENT UNTUK MENINGKATKAN KEDISIPLINAN BELAJAR SISWA SMA
Authors: Fatimah Annisa Nurul , Sujayati Winny , Yuliani Wiwin 
Published: June 2022

Tujuan dari penelitian ini untuk mengetahui keefektifan teknik self management dalam meningkatkan kedisiplinan belajar pada siswa SMA. Metode penelitian yang digunakan pun menggunakan kajian literatur yang terdahulu. Subjek yang diteliti pun menggunakan subjek dari hasil penelitian terdahulu serta partisipan penelitiannya dengan hasil yang sesuai dengan pembahasan kali ini. Hasil penelitian konseling self management dapat digunakan dalam meningkatkan kedisiplinan belajar pada siswa SMA. Hal ini terbukti dengan perubahan pola perilaku subjek yang diteliti mengalami perubahan dalam kedisiplinan belajarnya sebelum dan sesudah subjek melakukan proses konseling (menurut kajian terdahulu). Berdasarkan hasil penelitian terdahulu ini dapat disimpulkan bahwa konseling dengan menggunakan teknik self management dinyatakan efektif dalam meningkatkan kedisiplinan pada siswa SMA. Kata Kunci: Self-management, Kedidiplinan belajar
LAYANAN BIMBINGAN KARIER UNTUK MENGURANGI KECEMASAN SISWA SMA MENGHADAPI UJIAN NASIONAL
Authors: Laila Qareeba Putri , Amida Armi Ragil 
Published: June 2022

Layanan bimbingan karier yaitu suatu kegiatan berupa pemberian bantuan kepada siswa dengan tujuan agar siswa mampu menyesuaikan diri dan memperoleh pemahaman tentang dunia kerja sehingga pada akhirnya siswa mampu menentukan pilihan kerja dan membuat rencana karir. Tujuan penelitian ini untuk mengetahui layanan bimbingan karier dalam membantu siswa untuk lebih siap dalam menghadapi ujian nasional dan meniti karier kedepannya. Penelitian ini menggunakan pendekatan kualitatif deskriptif. Data mengenai tingkat kecemasan siswa diungkapkan dengan menggunakan wawancara. Hasil penelitian menunjukkan bahwa perasaan cemas yang dialami oleh siswa tidak diikuti dengan gejala-gejala berat yang dapat menganggu aktivitas atau bahkan menganggu jalannya ujian nasional. Layanan bimbingan karier bisa menjadi salah satu cara dalam mempersiapkan siswa dalam menghadapi ujian nasional, dan juga ujian akhir lainnya yang bertujuan sebagai langkah awal siswa dalam mempersiapkan jenjang kariernyaKata Kunci: layanan bimbingan karier, ujian nasional, kecemasan