bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photosynthesis of hybrid silver‐based nanoparticles mediated lectins and evaluation of their hemagglutinating properties
Authors: da S Fernandes Diógenes G. , Capo Graziella S. , Tofanello Aryane , Castro Carlos E. , Foltran Bruno B. , Squina Fabio M. , Santos Maria H. C , Silva Romério R. S. , Teixeira Claudener S. , Garcia Wanius 
Published: November 2022

AbstractLectins are carbohydrate‐binding proteins belonging to the Leguminosae family. In this family stand out proteins extracted from species belonging to Diocleinae subtribe, which includes, for example, the seed lectin from Dioclea violacea (DVL) and the jack bean lectin Concanavalin A (ConA). Here, we report the photosynthesis of silver/silver chloride nanoparticles (NPs) assisted by ConA and DVL. The syntheses were simple processes using a green‐chemistry approach. Under electron microscopy, NPs heterogeneous in size, nearly spherical and covered by a thin lectin corona, were observed. Both NPs assisted by lectins were capable to cause strong rabbit erythrocytes agglutination with the same titers of hemagglutinating activities. These results indicate that both lectins maintained their biological activities even after association with the NPs and therefore are able to interact with biological membrane carbohydrates. However, for rabbit erythrocytes treated with proteolytic enzymes were observed different titers of hemagglutinating activities, suggesting differences in the spatial arrangement of the lectins on the surface of the NPs. This study provides evidences that these hybrid lectin‐coated silver/silver chloride NPs can be used for selective recognition and interaction with membrane carbohydrates and others biotechnological applications.
Comparing algorithms for characterizing treatment effect heterogeneity in randomized trials
Authors: Sun Sophie , Sechidis Konstantinos , Chen Yao , Lu Jiarui , Ma Chong , Mirshani Ardalan , Ohlssen David , Vandemeulebroecke Marc , Bornkamp Björn 
Published: November 2022

AbstractThe identification and estimation of heterogeneous treatment effects in biomedical clinical trials are challenging, because trials are typically planned to assess the treatment effect in the overall trial population. Nevertheless, the identification of how the treatment effect may vary across subgroups is of major importance for drug development. In this work, we review some existing simulation work and perform a simulation study to evaluate recent methods for identifying and estimating the heterogeneous treatments effects using various metrics and scenarios relevant for drug development. Our focus is not only on a comparison of the methods in general, but on how well these methods perform in simulation scenarios that reflect real clinical trials. We provide the R package benchtm that can be used to simulate synthetic biomarker distributions based on real clinical trial data and to create interpretable scenarios to benchmark methods for identification and estimation of treatment effect heterogeneity.
Green practices as an effective business strategy to influence the behavior of hotel guests in the luxury hotel sector: Evidence from an emerging market
Authors: Dang‐Van Thac , Wang Jianming , Vo‐Thanh Tan , Jiang Xinru , Nguyen Ninh 
Published: November 2022

AbstractResearchers have investigated the influence of green practices on consumer behavior in the last decades. However, findings indicate that consumers have different responses toward green practices. To advance the current literature, this study draws on the theoretical foundation of social identity theory to investigate the relationship between green practices and hotel guests' visit intention in the luxury hotel sector. The study also determines the mediating mechanisms of perceived value fit and promotion focus and the moderating mechanism of environmental behavior in this relationship. Sample data were collected from 473 hotel guests in China's luxury hotels. The results of structural equation modeling indicate that green hotel practices enhance visit intention and that perceived value fit and promotion focus positively mediate this relationship. Moreover, environmental behavior has a positive moderating effect on the link between green hotel practices and perceived value fit, as well as that between perceived value fit and visit intention. A robustness test with another sample data of 266 hotel guests confirms the hypothesis testing results. The findings of this study provide implications for researchers and business managers in understanding and managing the influence of green practices on hotel guests' behavior in the luxury hotel sector.
A systematic mapping study: The new age of software architecture from monolithic to microservice architecture—awareness and challenges
Authors: Razzaq Abdul , Ghayyur Shahbaz A. K. 
Published: November 2022

AbstractMicroservice architecture (MSA) is an emerging architectural style as an innovative approach that is growing in quality over time. Microservices are endorsed by various researchers to shatter the issues and limitations encountered by the use of aging approaches for monolithic legacy architecture styles. Nonetheless, there exists no state of the research exhaustive study on migration to MSA from monolithic architecture. MSA has made the need to design the development methods of software and styles of architectures that satisfy these demands. The design of software architecture is the ongoing rise of MSA to address the independent deployment, scalability, and maintenance requirements. In this article, a systematic mapping study (SMS) was performed, including the literature on the migration approaches published between 2010 and 2021 to evaluate the contemporary state of the art and practice of software architecting. This study outlines the awareness and importance of MSA. Seventy‐three studies were finally selected in this SMS. The following perspectives of this study are publication trends, main venues, the focus of research, migration approaches, migration challenges, successful factors after migration, and the potential for industrial adoption. We synthesize the data and give a summary of the state of the art. This study also provides future research directions and applications for adopting microservices.
Clinical characteristics and prognosis of cystic degeneration in retroperitoneal schwannoma: A retrospective study of 79 patients
Authors: Xiao Jianchun , Cai Lizhu , Pu Jun , Liu Wei , Jia Congwei , He Xiaodong 
Published: November 2022

AbstractBackground and PurposeDiagnosis of retroperitoneal schwannoma (RS), especially cystic RS, is frequently missed or delayed owing to its rarity, location, nonspecific symptoms, and similarities with other tumors on various imaging modalities. This study aimed to determine associations between clinical, radiological, and histopathologic features and outcome.Materials and MethodsSeventy‐nine patients with pathologically confirmed RS who underwent tumor resection between June 2010 and June 2020 were retrospectively reviewed and analyzed. Patients were stratified into three groups according to degree of tumoral cystic degeneration.ResultsCystic degeneration was significantly associated with multiple foci (p = 0.025), calcification (p = 0.012), and hemorrhage (p = 0.000), but not size (p = 0.08), high Ki‐67 (p = 0.094), malignancy (p = 0.115; prevalence of cystic degeneration in the benign and malignant groups were 53.9% vs 100%), rough margin (p = 0.162), or irregular shape (p = 0.369). Malignant RS was significantly associated with multiple lymph nodes enlargement (p = 0.034). Tumor size, margins, shape, or/and multiplicity did not significantly differ between benign and malignant tumors. No recurrence occurred in patients with benign RS (mean follow‐up, 45 months). All malignant tumors recurred; mean time to recurrence was 11.4 months (mean follow‐up, 33 months).ConclusionSince RS is misdiagnosed mostly as malignancy and diagnosis is often delayed, a suspicion is necessary for diagnosis when atypical features are present. In RS, cystic degeneration was not associated with tumor size, Ki‐67, or malignancy; however, it was significantly associated with multiple foci, calcification, and hemorrhage. Cystic degeneration and related factors are useful for the diagnosis of RS. Malignant RS should be considered when a mass involves multiple lymph nodes. Margins, morphology, and size are not associated with malignancy. Pathological tumor type, tumor location, and adjacent anatomic structures are associated with outcome.
Serum glycomic profile as a predictive biomarker of recurrence in patients with differentiated thyroid cancer
Authors: Kudelka Matthew R. , Lasanajak Yi , Smith David F. , Song Xuezheng , Hossain Mohammad S. , Owonikoko Taofeek K. 
Published: November 2022

AbstractPurposeThyroid cancer recurrence following curative thyroidectomy is associated with increased morbidity and mortality, but current surveillance strategies are inadequate for early detection. Prior studies indicate that tissue glycosylation is altered in thyroid cancer, but the utility of serum glycosylation in thyroid cancer surveillance remains unexplored. We therefore assessed the potential utility of altered serum glycomic profile as a tumor‐specific target for disease surveillance in recurrent thyroid cancer.Experimental designWe employed banked serum samples from patients with recurrent thyroid cancer post thyroidectomy and healthy controls. N‐glycans were enzymatically released from serum glycoproteins, labeled via permethylation, and analyzed by MALDI‐TOF mass spectrometry. Global level and specific subtypes of glycan structures were compared between patients and controls.ResultsWe evaluated 28 independent samples from 13 patients with cancer recurrence and 15 healthy controls. Global features of glycosylation, including N‐glycan class and terminal glycan modifications were similar between groups, but three of 35 individual glycans showed significant differences. The three glycans were biosynthetically related biantennary core fucosylated N‐glycans that only varied by the degree of galactosylation (G0F, G1F, and G2F; G: galactose, F: fucose). The ratio of G0F:G1F that captures reduced galactosylation was observed in patients samples but not in healthy controls (p = 0.004) and predicted thyroid cancer recurrence (AUC = 0.82, CI 95% = 0.64–0.99).ConclusionsAltered N‐glycomic profile was associated with thyroid cancer recurrence. This serum‐based biomarker would be useful as an effective surveillance tool to improve the care and prognosis of thyroid cancer after prospective validation.
Delayed tracheal necrosis presenting with stridor: A rare complication of surgery for differentiated thyroid cancer
Authors: Keditsu Keduovinuo , Dandekar Mitali , Yhome Khriesatalie , Keditsu Thejavinuo 
Published: November 2022

AbstractTracheal necrosis (TN) is a rare life‐threatening complication of thyroidectomy, generally diagnosed in the early postoperative period with neck swelling or subcutaneous emphysema. Late presentation with stridor has not been reported till date. We present a case of TN three weeks after surgery with stridor, managed with sternohyoid muscle cover.
A case report of two obstructive sleep apnea patients with cervical spine abnormalities and relevant literature review
Authors: Sun Anrong , Fang Rui , Luo Huiping 
Published: November 2022

AbstractObstructive sleep apnea (OSA) combined with cervical spine anatomy abnormalities could be an underestimated clinical problem. Here are two cases of this kind reported to draw attention to this issue.
Tophaceous gout of the nose in a male FMR1 premutation carrier
Authors: Tang Si Jie , Giri Shanthi , Pahlavan Nima , Han Sophia H. , Santos Ellery R. , Espinal Glenda , Aishworiya Ramkumar , Schneider Andrea , Hessl David , Rivera Susan M. , Hagerman Randi J. 
Published: November 2022

AbstractPremutation alleles with 55–200 CGG repeats in FMR1 can lead to fragile X‐associated tremor/ataxia syndrome (FXTAS). In this case study, we report uncontrolled gout in a 68‐year‐old male with FXTAS with multiple sites of involvement including a rare gouty tophus in the nasal region.
Recovery of diabetes insipidus after Chiari malformation decompression: A rare manifestation of Chiari malformation
Authors: Roohollahi Faramarz , Iranmehr Arad , Mousavi Seyed Taher , Hajiabadi Mohamadreza 
Published: November 2022

AbstractThis paper aims to introduce a patient with Chiari type 1 malformation presented with upper extremity pain and diabetes insipidus. After laboratory examinations, we confirmed our case's central diabetes insipidus diagnosis. The patient has undergone posterior fossa decompression, tonsilopexy, and duraplasty. After 6 months of follow‐up, pain and diabetes insipidus were improved. We introduced a rare presentation of Chiari malformation in this article.
Transcolonic misplacement as a rare complication associated with PEG tube
Authors: Kozyk Marko , Strubchevska Kateryna , Batke Mihaela 
Published: November 2022

AbstractPEG tube placement is a relatively safe procedure; however, complications sometimes occur. Our article will allow readers to visualize the uncommon complication of PEG ‐ a transcolonic misplacement.
The spectrum of cutaneous polyarteritis nodosa. A case report of two contrasting cases and review of the literature
Authors: Liang Ian , Hamid Mariya , Sebaratnam Deshan , Manolios Nicholas 
Published: November 2022

AbstractCutaneous polyarteritis nodosa is a rare neutrophilic vasculitis. We present two cases that reflect the gamut of this disorder including one case whose delayed diagnosis led to permanent nerve deficit and scarring.
Mucinous breast carcinoma with neuroendocrine differentiation: Case report
Authors: Limaiem Faten , Bouraoui Saadia 
Published: November 2022

AbstractMucinous carcinoma of the breast is rare representing 2% of all breast carcinomas. It can be classified as either a pure or a mixed type. Pure mucinous breast carcinoma has a less aggressive behavior compared with mixed breast mucinous carcinoma. The latter shows frequent neuroendocrine differentiation.
Pulmonary aspergilloma with prominent oxalate deposition
Authors: Limaiem Faten , Blibech Hana , Bouhajja Leila , Ben Farhat Leila , Louzir Bechir 
Published: November 2022

AbstractSome Aspergillus species produce oxalic acid, which reacts with tissue calcium or blood to precipitate calcium oxalate. Oxalate crystals can induce lung and kidney damage. The presence of oxalate crystals can suggest the diagnosis of aspergillosis, even when Aspergillus hyphae are absent on microscopic slides.
High‐performance and wide relative humidity passive evaporative cooling utilizing atmospheric water
Authors: Wang Guang , Li Yang , Qiu Huihe , Yan He , Zhou Yanguang 
Published: November 2022

AbstractGlobal warming and increased living standards have rapidly increased the demand for cooling systems. Meeting this demand in less economically developed areas is highly challenging due to a lack of electricity. In this paper, we have demonstrated a high‐performance and wide relative humidity (RH) solar‐driven evaporative cooling strategy that uses only atmospheric water. Developed here for the first time, we designed a metal–organic framework (MOF‐801) based composite with a high‐performance atmospheric water absorption across a wide range of RH. The as‐synthesized composite can adsorb atmospheric water up to ~22% (~80%) of its weight at an RH@28% (~70%). Our demonstration has shown that the corresponding cooling powers range from 136 to 344 W/m2 in a wide range of RH and solar intensities, and the passive cooling temperature is up to 14°C lower than the device's reference counterpart. Our study thus proposes a solar‐driven cooling coating with high cooling powers across a wide range of RH based on an as‐synthesized composite, which pinpoints a pathway to replace traditional compression‐based cooling systems (e.g., air conditioners) and which will also have a significant impact in future global energy consumption.
Novel field observations of coral reef fishes feeding on epiphytic and epizoic organisms associated with the allelopathic seaweed Galaxaura divaricata
Authors: Nieder Carolin , Liao Chen‐Pan , Lee Chen‐Lu , Clements Kendall D. , Liu Shao‐Lun 
Published: November 2022

AbstractIn degraded coral reef ecosystems, allelopathic macroalgae have received increasing attention from marine ecologists because their secondary metabolites (also known as allelochemicals) kill corals that grow adjacent to them and weaken the recovery of degraded reefs. One well‐known coral‐killing macroalga is the calcareous red seaweed Galaxaura. However, our knowledge of how coral reef fishes interact with allelopathic algae like Galaxaura is very limited. Here, we documented novel observations of feeding interactions of 17 species of coral reef fishes (herbivorous and carnivorous) with the filamentous Galaxaura divaricata on degraded lagoon patch reefs in Dongsha Atoll (South China Sea). Video analyses showed that territorial farming damselfishes (i.e., Dischistodus perspicillatus, D. prosopotaenia, Hemiglyphidodon plagiometopon, Pomacentrus grammorhynchus, P. adelus, and Neoglyphidodon nigroris) and juvenile parrotfishes (Scarus schlegeli, S. ghobban, S. rivulatus, and Chlorurus spilurus) likely used G. divaricata as a feeding substratum. Further, microscopic analyses revealed that the filamentous surface of G. divaricata harbored a wealth of epiphytic microalgae, such as filamentous cyanobacteria (i.e., Leptolyngbya, Lyngbya, Rivularia, Oscillatoria, and Stigonema), diatoms (i.e., Synedra, Nitzschia, Mastogloia, and Pleurosigma), and filamentous red algae (i.e., Heterosiphonia), suggesting that these fishes targeted the nutrient‐rich microscopic epiphytes rather than the nutrient‐poor host. Juvenile benthic carnivores (i.e., Labridae, Parupeneus multifasciatus, and Meiacanthus grammistes) form feeding assemblages with roving parrotfishes to feed on small invertebrates (i.e., amphipods, copepods, isopods, gastropods, and polychaetes) associated with G. divaricata. Given that coral reef fishes appear to target the epiphytes associated with Galaxaura rather than the alga itself, these observations thus substantiate the threat posed by the overgrowth of G. divaricata to coral recovery in degraded reef systems due to the lack of natural grazers.
Population genomic analyses support sympatric origins of parapatric morphs in a salamander
Authors: Buckingham Emily , Streicher Jeffrey W. , Fisher‐Reid M. Caitlin , Jezkova Tereza , Wiens John J. 
Published: November 2022

AbstractIn numerous clades, divergent sister species have largely non‐overlapping geographic ranges. This pattern presumably arises because species diverged in allopatry or parapatry, prior to a subsequent contact. Here, we provide population‐genomic evidence for the opposite scenario: previously sympatric ecotypes that have spatially separated into divergent monomorphic populations over large geographic scales (reverse sympatric scenario). We analyzed a North American salamander (Plethodon cinereus) with two color morphs that are broadly sympatric: striped (redback) and unstriped (leadback). Sympatric morphs can show considerable divergence in other traits, and many Plethodon species are fixed for a single morph. Long Island (New York) is unusual in having many pure redback and leadback populations that are spatially separated, with pure redback populations in the west and pure leadbacks in the east. Previous work showed that these pure‐morph populations were genetically, morphologically, and ecologically divergent. Here, we performed a coalescent‐based analysis of new data from 88,696 single‐nucleotide polymorphisms to address the origins of these populations. This analysis strongly supports the monophyly of Long Island populations and their subsequent divergence into pure redback and pure leadback populations. Taken together, these results suggest that the formerly sympatric mainland morphs separated into parapatric populations on Long Island, reversing the conventional speciation scenario.
Gaussian process forecasts Pseudogymnoascus destructans will cover coterminous United States by 2030
Authors: Wiens Ashton M. , Thogmartin Wayne E. 
Published: November 2022

AbstractWhite‐nose syndrome has been decimating populations of several bat species since its first occurrence in the Northeastern United States in the winter 2006–2007. The spread of the disease has been monitored across the continent through the collaboration of many organizations. Inferring the rate of spread of the disease and predicting its arrival at new locations is critical when assessing the current and predicting the future status and trends of bat species. We developed a model of disease spread that simultaneously achieves high‐predictive performance, computational efficiency, and interpretability. We modeled white‐nose syndrome spread using Gaussian process variations to infer the spread rate of the disease front, identify areas of anomalous time of arrival, and provide future forecasts of the expected time of arrival throughout North America. Cross‐validation of model predictive performance identified a stationary Gaussian process without an additional residual error process as the best‐supported model. Results indicated that white‐nose syndrome is likely to spread throughout the entire continental United States by 2030. These annually updatable model predictions will be useful in determining the horizon over which disease management actions must take place as well as in status and trend assessments of disease‐affected bats.
Research status of the effects of natural oligosaccharides on glucose metabolism
Authors: Zhang Minjiao , Chen Yaobin , Chen Ruoxin , Wen Yuxi , Huang Qihui , Liu Yuanyuan , Zhao Chao 
Published: November 2022

AbstractDiabetes is a common and frequently occurring endocrine and metabolic disease characterized by hyperglycemia with genetic tendency. At present, the drugs for diabetes include metformin, glimepiride, and acarbose. Although these drugs are effective, long‐term usage will produce secondary symptoms, such as Cushing's syndrome, limb hypertrophy, and even the risk of hypoglycemia. Many natural products have been found to treat diabetes, among which oligosaccharides are the most valuable. Oligosaccharides are low‐level oligosaccharides formed by the linkage of 2–10 monosaccharides through glycosidic bonds. Common oligosaccharides include chitosan oligosaccharides, xylooligosaccharides, konjac glucomannan, and brown algae oligosaccharides. It has the effects of reducing blood glucose, blood pressure, antioxidant, anti‐inflammatory, immune regulation, antiallergy, promoting the growth of bifidobacteria, and improving body health. With the continuous exploration of the medicinal value of natural oligosaccharides, more and more attention has been paid to their research. This review introduces some representative oligosaccharides with hypoglycemic effects, including their structural characteristics and hypoglycemic mechanism, as well as the application status and future development trend of oligosaccharides.