bluuebunny/crossref_metadata_2025_split huggingface dataset:
Algorithms used in medical image segmentation for 3D printing and how to understand and quantify their performance
Authors: Fogarasi Magdalene , Coburn James C. , Ripley Beth 
Published: June 2022

AbstractBackground3D printing (3DP) has enabled medical professionals to create patient-specific medical devices to assist in surgical planning. Anatomical models can be generated from patient scans using a wide array of software, but there are limited studies on the geometric variance that is introduced during the digital conversion of images to models. The final accuracy of the 3D printed model is a function of manufacturing hardware quality control and the variability introduced during the multiple digital steps that convert patient scans to a printable format. This study provides a brief summary of common algorithms used for segmentation and refinement. Parameters for each that can introduce geometric variability are also identified. Several metrics for measuring variability between models and validating processes are explored and assessed.MethodsUsing a clinical maxillofacial CT scan of a patient with a tumor of the mandible, four segmentation and refinement workflows were processed using four software packages. Differences in segmentation were calculated using several techniques including volumetric, surface, linear, global, and local measurements.ResultsVisual inspection of print-ready models showed distinct differences in the thickness of the medial wall of the mandible adjacent to the tumor. Volumetric intersections and heatmaps provided useful local metrics of mismatch or variance between models made by different workflows. They also allowed calculations of aggregate percentage agreement and disagreement which provided a global benchmark metric. For the relevant regions of interest (ROIs), statistically significant differences were found in the volume and surface area comparisons for the final mandible and tumor models, as well as between measurements of the nerve central path. As with all clinical use cases, statistically significant results must be weighed against the clinical significance of any deviations found.ConclusionsStatistically significant geometric variations from differences in segmentation and refinement algorithms can be introduced into patient-specific models. No single metric was able to capture the true accuracy of the final models. However, a combination of global and local measurements provided an understanding of important geometric variations. The clinical implications of each geometric variation is different for each anatomical location and should be evaluated on a case-by-case basis by clinicians familiar with the process. Understanding the basic segmentation and refinement functions of software is essential for sites to create a baseline from which to evaluate their standard workflows, user training, and inter-user variability when using patient-specific models for clinical interventions or decisions.
Utility of sirolimus coated balloons in the peripheral vasculature – a review of the current literature
Authors: Linn Y. L. , Choke E. T. C. , Yap C. J. Q. , Tan R. Y. , Patel A. , Tang T. Y. 
Published: June 2022

AbstractSirolimus-coated balloons (SCB) have demonstrated much promise as an alternative drug eluting device to the existing paclitaxel coated balloon platforms for the treatment of peripheral arterial disease (PAD). They have been well tested pre-clinically and have demonstrated anti-restenotic effects as well as clinical safety in its use for treatment of coronary artery disease. The existing approved SCBs have thus far demonstrated good short-term patency (12-months) and did not exhibit any major adverse events or device related shortcomings in its use for treatment of PAD. There are several studies ongoing which aim to further investigate the efficacy of existing SCBs and establish a direct comparison of its outcomes compared with plain balloon angioplasty. Also, SCB utility to salvage failing arteriovenous fistulas for haemodialysis patients has also been explored. We review the current progress made in the establishment of SCB in the treatment of PAD as well as highlight ongoing studies investigating the role of SCB in various settings.
ASD Formation Prior to Material Characterization as Key Parameter for Accurate Measurements and Subsequent Process Simulation for Hot-Melt Extrusion
Authors: Kayser Kevin , Monschke Marius , Wagner Karl G. 
Published: June 2022

Abstract
Process simulation facilitates scale-up of hot-melt extrusion (HME) and enhances proper understanding of the underlying critical process parameters. However, performing numeric simulations requires profound knowledge of the employed materials’ properties. For example, an accurate description of the compounds’ melt rheology is paramount for proper simulations. Hence, sample preparation needs to be optimized to yield results as predictive as possible. To identify the optimal preparation method for small amplitude oscillatory shear (SAOS) rheological measurements, binary mixtures of hydroxypropylmethylcellulose acetate succinate or methacrylic acid ethyl acrylate copolymer (Eudragit L100-55) together with the model drugs celecoxib and ketoconazole were prepared. The physical powder mixtures were introduced into the SAOS as a compressed tablet or a disk prepared via vacuum compression molding (VCM). Simulations with the derived parameters were conducted and compared to lab-scale extrusion trials. VCM was identified as the ideal preparation method resulting in the highest similarity between simulated and experimental values, while simulation based on conventional powder-based methods insufficiently described the HME process.
Case of Recurrent Primary Hyperparathyroidism, Congenital Granular Cell Tumor, and Aggressive Colorectal Cancer
Authors: Afreen Samina , Weinstein Lee S , Simonds William F , Jha Smita 
Published: June 2022

Abstract
We present the case of a 53-year-old African-American male with recurrent primary hyperparathyroidism (PHPT), multifocal benign granular cell tumor (GCT), and metastatic colon adenocarcinoma. PHPT was diagnosed on routine blood testing (ionized calcium, 1.66 [1.12-1.32] mmol/L; PTH 110 pg/mL, vitamin D-25-OH-D: 18 ng/mL; PTHrP: undetectable). Medical history was notable for 2 reoccurrences of PHPT with persistent disease after most recent parathyroidectomy. Lymph node (LN) dissection during this last surgery showed a 2-mm focus of poorly differentiated adenocarcinoma in 1/5 LNs. Additionally, the patient had a history of multifocal GCTs diagnosed at age 2 years. On examination, there were no Lisch nodules, axillary, or inguinal freckling, neurofibromas, or café-au-lait macules but a prominent abdominal wall nodule was noted. En bloc resection of a tumor in the tracheoesophageal groove, identified by sestamibi scan, and excision of 4.5-cm abdominal wall nodule showed both masses having histology consistent with GCT. Serum calcium and PTH did not decrease, indicating another unsuccessful surgery. Genetic testing was negative for germline variants in PHPT-associated genes, APC, or genes of RAS-MAPK signaling pathway. The LN finding of metastatic adenocarcinoma prompted an endoscopy and transbronchial biopsy leading to the diagnosis of widely metastatic colonic adenocarcinoma, eventually resulting in his death a year later. The source of the patient’s persistent PHPT remained unidentified. This is the first case with coassociation of recurrent PHPT, multifocal GCT, and colon cancer. Whether the disparate tumors in this patient share common driver(s) remains unknown. Prospective surveillance of patients for similar associations may provide clues for a novel syndromic form of PHPT.
ALDH2 variance in disease and populations
Authors: Chen Che-Hong , Kraemer Benjamin R. , Mochly-Rosen Daria 
Published: June 2022

ABSTRACT
The ALDH2*2 missense variant that commonly causes alcohol flushing reactions is the single genetic polymorphism associated with the largest number of traits in humans. The dysfunctional ALDH2 variant affects nearly 8% of the world population and is highly concentrated among East Asians. Carriers of the ALDH2*2 variant commonly present alterations in a number of blood biomarkers, clinical measurements, biometrics, drug prescriptions, dietary habits and lifestyle behaviors, and they are also more susceptible to aldehyde-associated diseases, such as cancer and cardiovascular disease. However, the interaction between alcohol and ALDH2-related pathology is not clearly delineated. Furthermore, genetic evidence indicates that the ALDH2*2 variant has been favorably selected for in the past 2000-3000 years. It is therefore necessary to consider the disease risk and mechanism associated with ALDH2 deficiency, and to understand the possible beneficial or protective effect conferred by ALDH2 deficiency and whether the pleiotropic effects of ALDH2 variance are all mediated by alcohol use.
LA SEGUNDA PERSONA Y LA TEORÍA DE LA MENTE
Authors: Inés Pérez Diana 
Published: June 2022

RESUMEN: El propósito de este trabajo es identificar el rol le podemos asignar a la así llamada teoría de la mente (ToM) en el marco de la perspectiva de segunda persona de la atribución mental (P2P). En el primer apartado explicitaré diferentes concepciones de ToM, y en el segundo señalaré las dificultades que enfrenta. En la tercera parte del trabajo presentaré sintéticamente algunas ideas nucleares de la P2P, y finalmente en la última sección mostraré qué rol le podemos asignar a cierta manera de entender ToM dentro del marco de la P2P.
PALABRAS CLAVE: Psicología folk; Postcognitivismo; Creencia; Conceptos psicológicos.

ABSTRACT: The purpose of this paper is to identify the role we can assign to the so-called Theory of Mind (ToM) within the second person perspective of mental attribution (2PP). In the first section I will explain different conceptions of ToM, and in the second I will point out the difficulties it faces. In the third part, I will present some core ideas of the 2PP, and finally in the last section I will explain the role we can assign to a certain way of understanding ToM within the 2PP framework.
KEYWORDS: Folk psychology; Postcognitivism; Belief; Mental concepts.
Effects of dance therapy in women with breast cancer: A systematic review protocol
Authors: Silva da Costa Natália , Alves da Silva Amanda Suzane , de Melo-Neto João Simão 
Published: June 2022

Background
Cancer is an important public health problem with an increasing global incidence in the recent decades. Breast cancer has become the leading cause of death in women worldwide. Women suffering from breast cancer, as well as survivors, may experience some adverse effects of treatment–including cancer-related fatigue, sleep disorders, and pain–which may manifest alone or in combination with other symptoms. Non-pharmacological interventions, such as physical activity, have been associated with improvements in these adverse effects. This study aims to evaluate the effects of dance therapy in women with breast cancer.

Methods
We will perform a systematic review according to the Cochrane methodology. An overall search strategy will be developed and adapted for PubMed, Virtual Health Library, PEDro, SciELO, SciVerse Scopus, Cochrane Library, and Web of Science using the descriptors “Dance therapy” or “Dancing” and “Breast neoplasms” or “Breast cancer.” The size of the intervention effect (Z) will be calculated for each outcome included in this review. Outcomes will be pain, cancer-related fatigue, sleep disturbance, body image and depression in women with breast cancer. Quality assessment will be performed using the Cochrane instrument. Metanalysis, if plausible, will be performed using Review Manager 5.3.

Discussion
Studies have reported positive results of dance therapy as a non-pharmacological intervention in women with breast cancer. Thus, it is expected that robust and conclusive evidence of the effects of dance therapy during or after treatment (radiotherapy, chemotherapy, hormone therapy, and/or surgery) can be obtained.

Trial registration
Systematic review registration: CRD42020152876. (S1 File).
The missing bit in the middle: Implementation of the Nationals Health Services Standards for Papua New Guinea
Authors: Schuele Elisabeth , MacDougall Colin 
Published: June 2022

Objective
This case study examined implementation of the National Health Services Standards (NHSSs) as a continuous quality improvement (CQI) process at three church-based health facilities in Papua New Guinea. This process was designed to improve quality of care and accredit the level three health centers to level four as district hospitals to provide a higher level of care. The aims of the paper are to critically examine driving and restraining forces in CQI implementation and analyses how power influences agenda setting for change.

Methods
Semi-structured interviews were conducted with nine managers and eight health workers as well as three focus group discussions with health workers from three rural church-based health facilities in Morobe and Madang provinces. They included senior, mid-level and frontline managers and medical doctors, health extension officers, nursing officers and community health workers. Thematic analysis was used as an inductive and deductive process in which applied force field analysis, leadership-member exchange (LMX) theory and agenda setting was applied.

Results
Qualitative analysis showed how internal and external factors created urgency for change. The CQI process was designed as a collective process. Power relations operated at and between various levels: the facilities, which supported or undermined the change process; between management whereby the national management supported the quality improvement agenda, but the regional management exercised positional power in form of inaction. Theoretical analysis identified the ‘missing bit in the middle’ shaped by policy actors who exercise power over policy formulation and constrained financial and technical resources. Analysis revealed how to reduce restraining forces and build on driving forces to establish a new equilibrium.

Conclusion
Multiple theories contributed to the analysis showing how to resolve problematic power relations by building high-quality, effective communication of senior leadership with mid-level management and reactivated broad collaborative processes at the health facilities. Addressing the ‘missing bit in the middle’ by agenda setting can improve implementation of the NHSSs as a quality improvement process. The paper concludes with learning for policy makers, managers and health workers by highlighting to pay close attention to institutional power dynamics and practices.
Psychometric properties of the Malay version of the Behavioural Regulation in Exercise Questionnaire (BREQ-3)
Authors: Chai Shirlie , Kueh Yee Cheng , Majdi Yaacob Najib , Kuan Garry 
Published: June 2022

Background
The present study aimed at validating the Malay-language version of the Behavioural Regulation in Exercise Questionnaire (BREQ-3M) using confirmatory factor analysis (CFA).

Methods
Data were collected from undergraduate students in the Health Campus, Universiti Sains Malaysia. A total of 674 students completed the BREQ-3M (male: 19.4%, female: 80.6%), with a mean age of 20.27 years (SD = 1.35). Behavioural regulation was assessed with the 24-item BREQ-3M. Standard forward-backward translation was performed to translate the English version of BREQ-3 into the Malay version.

Results
The initial measurement models tested did not result in a good fit for the data. Subsequent examination of the CFA results suggested some modifications, including adding correlations between the item residuals within the same subscale and deletion of identified regulation. These modifications resulted in good fit indices (Root Mean Square Error of Approximation, RMSEA = 0.049; Comparative Fit Index, CFI = 0.949; Tucker-Lewis Index, TLI = 0.938; Standardised Root Mean Square Residual, SRMR = 0.049). The final measurement model comprised 20 items and had significant factor loadings of more than 0.50, ranging from 0.580 to 0.868. The composite reliability ranged between 0.746–0.841 for the five-factor model.

Conclusions
The 20-item translated version of BREQ-3M is valid and reliable for assessing the behavioural regulation for exercise among university students in Malaysia.

Perspective
This study examined the psychometric properties of the Malay-language BREQ-3. It was the first to assess the measurement model in Malaysia using CFA.
Prosocial behavior and youth mental health outcomes: A scoping review protocol
Authors: Hirani Saima , Ojukwu Emmanuela , Bandara Nilanga Aki 
Published: June 2022

Introduction
This review aims to explore the existing literature about the virtue of helping others and its association with youth mental health. Mental health of youth is rooted in their social environment. Helping others or engaging in prosocial behavior are activities that youth may participate in. The notion of helping others and its association with individual mental well-being have been well-studied for adults and older adults and to some extent in youth, however, no review has been conducted to understand the intersection of helping others and mental health in the youth population.

Methods
This review will consider all study designs that examine helping others and mental health of youth. The inclusion criteria for the review will include young individuals aged 10-24-year-old, living in any geographic location, of all gender identities, and with or without mental health issues. Grey literature and studies that only speak to outcomes related to physical well-being will be excluded. A search will be conducted in CINAHL, MEDLINE and PsycINFO. Studies published in the English language will be included with no restriction on publication time period. Articles will be screened against the inclusion criteria onto a single software by two independent reviewers. In the case of any disagreement, a third independent reviewer would resolve the conflict.

Findings
Data will be extracted and presented in a tabular or diagrammatic form supported by a summary. We will report our findings in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews (PRISMA-ScR). The findings of this review will provide evidence-based recommendations for promoting youth mental health and a basis for future research.
Pittsburgh Sleep Quality Index (PSQI) responses are modulated by total sleep time and wake after sleep onset in healthy older adults
Authors: Zitser Jennifer , Allen Isabel Elaine , Falgàs Neus , Le Michael M. , Neylan Thomas C. , Kramer Joel H. , Walsh Christine M. 
Published: June 2022

Objectives
To investigate the objective sleep influencers behind older adult responses to subjective sleep measures, in this case, the Pittsburgh Sleep Quality Index (PSQI). Based on previous literature, we hypothesized that SE would be associated with PSQI reported sleep disruption. Furthermore, because SOL increases progressively with age and it tends to be easily remembered by the patients, we also expected it to be one of the main predictors of the perceived sleep quality in the elderly.

Methods
We studied 32 cognitively healthy community-dwelling older adults (age 74 ± 0.3 years) who completed an at-home sleep assessment (Zeo, Inc.) and the PSQI. Linear mixed models were used to analyze the association of the objective sleep parameters (measured by the Zeo) with the PSQI total score and sub-scores, adjusting for age, gender, years of education and likelihood of sleep apnea.

Results
Objective sleep parameters did not show any association with the PSQI total score. We found that objective measures of Wake after sleep onset (WASO, % and min) were positively associated with the PSQI sleep disturbance component, while SE and Total Sleep Time (TST) were negatively associated with PSQI sleep disturbance. Lastly, objective SE was positively associated with PSQI SE.

Conclusions
Our findings showed that WASO, SE and TST, are associated with PSQI sleep disturbance, where the greater WASO, overall lower SE and less TST, were associated with increased subjective report of sleep disturbance. As expected, subjective (PSQI) and objective measures of SE were related. However, PSQI total score did not relate to any of the objective measures. These results suggest that by focusing on the PSQI total score we may miss the insight this easily administered self-report tool can provide. If interpreted in the right way, the PSQI can provide further insight into cognitively healthy older adults that have the likelihood of objective sleep disturbance.
Modelling optimal use of temporarily restricted colonoscopy capacity in a FIT-based CRC screening program: Application during the COVID-19 pandemic
Authors: de Jonge Lucie , van de Schootbrugge-Vandermeer Hilliene J. , Breekveldt Emilie C. H. , Spaander Manon C. W. , van Vuuren Hanneke J. , van Kemenade Folkert J. , Dekker Evelien , Nagtegaal Iris D. , van Leerdam Monique E. , Lansdorp-Vogelaar Iris 
Published: June 2022

Objective
The COVID-19 pandemic forced colorectal cancer (CRC) screening programs to downscale their colonoscopy capacity. In this study, we assessed strategies to deal with temporary restricted colonoscopy capacity in a FIT-based CRC screening program while aiming to retain the maximum possible preventive effect of the screening program.

Design
We simulated the Dutch national CRC screening program inviting individuals between ages 55 and 75 for biennial FIT using the MISCAN-Colon model including the 3-month disruption in the first half of 2020 due to the COVID-19 pandemic. For the second half of 2020 and 2021, we simulated three different strategies for the total target population: 1) increasing the FIT cut-off, 2) skipping one screening for specific screening ages, and 3) extending the screening interval. We estimated the impact on required colonoscopy capacity in 2020–2021 and life years (LYs) lost in the long-term.

Results
Increasing the FIT cut-off, skipping screening ages and extending the screening interval resulted in a maximum reduction of 25,100 (-17.0%), 16,100(-10.9%) and 19,000 (-12.9%) colonoscopies, respectively. Modelling an increased FIT cut-off, the number of LYs lost ranged between 1,400 and 4,400. Skipping just a single screening age resulted in approximately 2,700 LYs lost and this was doubled in case of skipping two screening ages. Extending the screening interval up to 34 months had the smallest impact on LYs lost (up to 1,100 LYs lost).

Conclusion
This modelling study shows that to anticipate on restricted colonoscopy capacity, temporarily extending the screening interval retains the maximum possible preventive effect of the CRC screening program.