bluuebunny/crossref_metadata_2025_split huggingface dataset:
An inactivated novel chimeric FAdV-4 containing fiber of FAdV-8b provides full protection against hepatitis-hydropericardium syndrome and inclusion body hepatitis
Authors: Wang Baiyu , Song Mingzhen , Song Congcong , Zhao Shiyi , Yang Panpan , Qiao Qilong , Cong Yanfang , Wang Yanling , Wang Zeng , Zhao Jun 
Published: September 2022

AbstractFowl adenovirus serotype 4 (FAdV-4) and FAdV-8b are causative agents of hepatitis-hydropericardium syndrome (HHS) and inclusion body hepatitis (IBH), respectively. HHS and IBH co-infections were often reported in clinical, yet there are no commercially available bivalent vaccines for prevention and control of both FAdV-4 and -8b. In the present study, a chimeric FAdV-4 was firstly generated by substituting fiber-1 of FAdV-4 with fiber of FAdV-8b. The chimeric virus, rFAdV-4-fiber/8b, exhibited similar replication ability in vitro and pathogenicity in vivo to the parental wild type FAdV-4. A single dosage of vaccination with the inactivated rFAdV-4-fiber/8b induced high antibody titers against fiber-2 of FAdV-4 and fiber of FAdV-8b and provided full protection against FAdV-4 and -8b challenge. These results demonstrated that fiber of FAdV-8b could replace the role of fiber-1 of FAdV-4 in the process of viral infection, and rFAdV-4-fiber/8b could be used to make a potential bivalent vaccine for the control and prevention of HHS and IBH.
Research on unsupervised anomaly data detection method based on improved automatic encoder and Gaussian mixture model
Authors: Liu Xiangyu , Zhu Shibing , Yang Fan , Liang Shengjun 
Published: September 2022

AbstractWith the development of cloud computing, more and more security problems like “fuzzy boundary” are exposed. To solve such problems, unsupervised anomaly detection is increasingly used in cloud security, where density estimation is commonly used in anomaly detection clustering tasks. However, in practical use, the excessive amount of data and high dimensionality of data features can lead to difficulties in data calibration, data redundancy, and reduced effectiveness of density estimation algorithms. Although auto-encoders have made fruitful progress in data dimensionality reduction, using auto-encoders alone may still cause the model to be too generalized and unable to detect specific anomalies. In this paper, a new unsupervised anomaly detection method, MemAe-gmm-ma, is proposed. MemAe-gmm-ma generates a low-dimensional representation and reconstruction error for each input sample by a deep auto-encoder. It adds a memory module inside the auto-encoder to better learn the inner meaning of the training samples, and finally puts the low-dimensional information of the samples into a Gaussian mixture model (GMM) for density estimation. MemAe-gmm-ma demonstrates better performance on the public benchmark dataset, with a 4.47% improvement over the MemAe model standard F1 score on the NSL-KDD dataset, and a 9.77% improvement over the CAE-GMM model standard F1 score on the CIC-IDS-2017 dataset.
Bivariate hydrologic risk analysis for the Xiangxi River in Three Gorges Reservoir Area, China
Authors: Fan Y. R. 
Published: September 2022

Abstract
Background
Hydrological extremes such as floods generally have multidimensional attributes with complex dependence structures. This leads to the urgent demand of hydrological risk analysis within a multivariate context. In this study, the bivariate hydrologic risk framework is proposed based on the bivariate copula method. In the proposed risk analysis framework, bivariate flood frequency would be analyzed for different flood variable pairs (i.e., flood peak-volume, flood peak-duration, flood volume-duration), and the bivariate hydrologic risk is then derived based on the joint return period of a flood variable pair. The distribution of one flood variable conditional on another flood variable can also be obtained through the copula method.

Results
The proposed method is applied to the risk analysis for the Xiangxi River in the Three Gorges Reservoir area, China, based on 50 years streamflow measurements. The results indicate that the bivariate risk for flood peak flow-duration would keep constant for some time and then decrease as the increase of the flood duration. The bivariate risk for flood peak-volume holds a similar trend with the bivariate risk of flood peak-duration. The probability density functions (PDFs) of the flood volume and duration conditional on flood peak can also be generated through the best fitted copula function.

Conclusion
The results indicate that the distributions of flood volume would be highly influenced by the flood peak flows, in which the flood volume would be expected to increase as the increase of flood return period. Conversely, the distribution of the flood duration would not change significantly with the variation in the flood peak return period. The obtained conclusions from the bivariate hydrologic analysis can provide decision support for flood control and mitigation.
Estrogen receptor β deficiency impairs gut microbiota: a possible mechanism of IBD-induced anxiety-like behavior
Authors: Ma Yuanyuan , Liu Tianyao , Li Xin , Kong Anqi , Xiao Rui , Xie Ruxin , Gao Junwei , Wang Zhongke , Cai Yun , Zou Jiao , Yang Ling , Wang Lian , Zhao Jinghui , Xu Haiwei , Margaret Warner , Xu Xingshun , Gustafsson Jan-Ake , Fan Xiaotang 
Published: September 2022

Abstract
Background
Although the lack of estrogen receptor β (ERβ) is a risk factor for the development of inflammatory bowel disease (IBD) and psychiatric disorders, the underlying cellular and molecular mechanisms are not fully understood. Herein, we revealed the role of gut microbiota in the development of IBD and related anxiety-like behavior in ERβ-deficient mice.

Results
In response to dextran sodium sulfate (DSS) insult, the ERβ knockout mice displayed significant shift in α and β diversity in the fecal microbiota composition and demonstrated worsening of colitis and anxiety-like behaviors. In addition, DSS-induced colitis also induced hypothalamic-pituitary-adrenal (HPA) axis hyperactivity in ERβ-deficient mice, which was associated with colitis and anxiety-like behaviors. In addition, RNA sequencing data suggested that ErbB4 might be the target of ERβ that is involved in regulating the HPA axis hyperactivity caused by DSS insult. Gut microbiota remodeling by co-housing showed that both the colitis and anxiety-like behaviors were aggravated in co-housed wild-type mice compared to single-housed wild-type mice. These findings suggest that gut microbiota play a critical role in mediating colitis disease activity and anxiety-like behaviors via aberrant neural processing within the gut-brain axis.

Conclusions
ERβ has the potential to inhibit colitis development and anxiety-like behaviors via remodeling of the gut microbiota, which suggests that ERβ is a promising therapeutic target for the treatment of IBD and related anxiety-like behaviors.
HER2-targeted advanced metastatic gastric/gastroesophageal junction adenocarcinoma: treatment landscape and future perspectives
Authors: Li Weiling , Zhang Xiaoling , Du Yunyi , Zhang Ying , Lu Jing , Hu Wenqing , Zhao Jun 
Published: September 2022

AbstractRecently, the global incidence of gastric/gastroesophageal junction (G/GEJ) cancer has remained high. China is also a large country with a high gastric cancer (GC) incidence rate, where the cases of GC account for 40% of all cases worldwide. More than 90% of GEJ cancers are the adenocarcinoma pathological type. Patients with early-stage G/GEJ adenocarcinoma may have a better prognosis after surgery. In contrast, patients with advanced metastatic G/GEJ adenocarcinoma usually choose comprehensive treatment based on systemic pharmacotherapy, but the subsequent long-term survival is not optimistic. The discovery of various biomarkers, especially microsatellite instability (MSI), programmed cell death-ligand 1 (PD-L1), human epidermal growth factor receptor 2 (HER2), tumor mutational burden (TMB) and Epstein–Barr virus (EBV), has led to the identification of an increasing number of targeted populations and has greatly improved the clinical efficacy of treatments for G/GEJ adenocarcinoma. The ToGA trial added trastuzumab to standard chemotherapy, showed improved survival of patients with HER2-positive advanced G/GEJ adenocarcinoma and brought these patients into a new era of HER2-targeted therapy. Moreover, many HER2-targeted agents have been developed and studied in patients with advanced HER2-positive G/GEJ adenocarcinoma who have demonstrated excellent clinical outcomes. However, many patients experience disease progression with HER2-targeted therapy; hence, new anti-HER2 drugs keep being developed, significantly reducing HER2 resistance. This paper reviews HER2-targeted drugs for advanced metastatic G/GEJ adenocarcinoma, potential resistance mechanisms and future directions.
Ruptured ileocolic artery pseudoaneurysm after laparoscopic appendectomy for acute appendicitis
Authors: Takashima Junpei , Taniguchi Keizo , Koizumi Ayaka , Shigehara Fumi , Yamazaki Kenji , Fujimoto Daisuke , Miura Fumihiko , Kobayashi Hirotoshi 
Published: September 2022

Abstract
Background
A pseudoaneurysm of the splanchnic vessels is considered to be rare, and in particular, very few cases of pseudoaneurysm in the ileocolic artery are reported. Here, we report a case of rupture of a pseudoaneurysm of the appendicular branch of the ileocolic artery after laparoscopic appendectomy.

Case presentation
A 52-year-old man was diagnosed as having phlegmonous appendicitis, and an emergency laparoscopic appendectomy was performed. Bleeding from the inter-appendicular ligament during detachment of adhesions was stopped by white coagulation and Z-suture, and the inter-appendicular ligament was treated. The postoperative course was uneventful, and there were no adverse events or findings suggestive of abscess formation. On postoperative day 30, he presented with a ruptured pseudoaneurysm of the appendicular branch of the ileocolic artery. A definitive diagnosis was made by computed tomography, and emergency interventional radiology was performed with hemostasis achieved by coiling. The patient’s postprocedure course was favorable, and he was discharged with no adverse events, such as intestinal ischemia.

Conclusions
We experienced a case of delayed pseudoaneurysm rupture after laparoscopic appendectomy. Care must be taken when handling the appendicular artery during the procedure, and the potential for pseudoaneurysm formation should be considered at postoperative follow-up.
The Iranian form of psychometric properties of the Multidimensional Psychological Flexibility Inventory
Authors: Azadfar Zahra , Abdollahi Abbas , Patra Indrajit , Chang Ya-Ping , Alghazali Tawfeeq , Talib Saad Ghazi 
Published: September 2022

AbstractThe Multidimensional Psychological Flexibility Inventory (MPFI) is a new 60-item self-report scale developed to assess the specific components of psychological flexibility and inflexibility proposed in the Hexaflex model of Acceptance and Commitment Therapy (ACT). The present study sought to examine the psychometric properties of the Persian version of the MPFI-60 in a community sample of 307 Iranian adults. The original study supported a 12-factor second-order structure consisting of 6 dimensions for psychological flexibility and 6 dimensions for psychological inflexibility. The Persian MPFI-60 demonstrated acceptable semantic and test content, internal structure, correlations with other variables, and internal consistency. It also evidenced in relation to anxiety, stress, depression, and self-compassion. Overall, the results indicate that the Persian MPFI-60 is a psychometrically sound measure in the Iranian context that enables researchers and clinicians to comprehensively assess the components of psychological flexibility and inflexibility within the Hexaflex model.
Evaluating costal cartilage for sex and age estimation from PA chest radiographs of North Indian population: a retrospective study
Authors: Patyal Shama , Bhatia Tejasvi 
Published: September 2022

Abstract
Background
This study is conducted to estimate age and sex from chest radiographs. The aim of this study was to determine (I) whether costal cartilage calcification pattern help in estimating sex in North Indian sample and (ii) whether there is any relation between age and costal cartilage calcification.

Results
The statistical probability of estimating peripheral pattern in male was 99.3%, and for females, it was 100% for central type of calcification. The minimum age where lower costal calcification was present was 22-year-old female and 21 years old male. The degree of calcification and age showed positive correlation; similarly, the value of spearman’s rho showed significant result (for whole sample rs = 0.911, p < 0.01 (for male subjects, it was rs = 0.921, p < 0.01; for females, it was rs = 0.905, p < 0.01)).

Conclusions
The degree of calcification is useful in estimating age groups and becomes more determined with advancing age. Prediction of sex by using radiological method gives the advantages of simplicity, inexpensiveness, speed, and high accuracy. This method for age and sex estimation will play a useful role in screening test and in cases where the thoracic part of the body is found like dismembered body, putrefied dead remains, and unidentified bodies.
Distribution of different minutiae in thumbprint and its application to determine sex distinctions
Authors: Kaur Maninder , Kaur Jatinder , Kaur Amandeep , Kamal Preet 
Published: September 2022

Abstract
Background
The present study is an attempt to explore the distribution of different minutiae in two topological areas of thumbprint and its application to determine sex distinctions.

Methods
For this purpose, a sample of 100 subjects (50 males and 50 females) ranging in age from 18 years to 25 years were taken from the Shimla (North India). A modified standardized method was adopted to count and classify 20 different types of minutiae.

Results
Findings of the study indicated that the frequency of thumbprint minutiae was higher among males than their female counterparts. Ridge endings were the most frequently occurring minutiae followed by bifurcation and convergence in both the sexes. No M-B was noticed among female participant, while negligible percentage (0.04%) of males exhibited M-B. The mean values of most of the minutiae were found to be higher in the outer circle than inner circle of the thumbprint in both the sexes. Lower frequency of ridge ending (< 20 for right hand and 31–40 for both right and left hand), convergence (< 10 for both right and left hand), and bifurcation (< 10 and 31–40 for right hand and < 20 for left hand) have higher probability of female origin. While higher frequency of ridge ending (> 60 for right hand and > 50 for left hand), convergence (> 20 for both right and left hand) and bifurcation (> 40 for right hand and > 30 for left hand) was more likely of male origin.

Conclusions
Findings of present study identified sex distinction in the distribution of minutiae with respect to the topological areas on the thumbprint.
Utilization of carbon nanotubes and steel fibers to improve the mechanical properties of concrete pavement
Authors: Hassan Abeer , Galal Sameh , Hassan Ahmed , Salman Amany 
Published: September 2022

Abstract
Background
Rigid pavements have become an urgent demand in recent years, as these pavements need less maintenance and renovation than other types. However, traditional rigid pavement faces various challenges and difficulties over its lifetime. It has a much higher initial erection cost than asphalt pavements, a greater sensitivity to dynamic stresses, and a highly susceptible to temperature variations causing cracking. Previous works dealt with these drawbacks by using effective materials as alternatives to cement and/or aggregates in pavements mixtures. In the last few years, much interest has been carried out in nanomaterial applications to improve the mechanical performance of construction materials, which can also be used for rigid pavement constructions. This improvement is due to nanomaterials' role in concrete as nanoreinforcements and nanofillers. On the other hand, various types of fibers have been used to improve the performance of concrete constructions. This study investigates the effect of adding carbon nanotubes (CNTs) and steel fibers (SFs) to concrete mixtures. A series of experiments on concrete mixes with various weight percentages of CNTs (0%, 0.025%, 0.050%, and 0.075%) were added to the mixtures to determine the best cost and amount of CNTs to add to a concrete mix. Compressive, tensile, and flexure strength characteristics are investigated. In the second experimental stage of this work, the effect of adding steel fibers to the mixture was investigated.

Results
According to the results, the optimal carbon nanotube content in concrete is 0.05%. Compared to other concrete combinations with varying proportions of CNTs, this quantity offers the maximum compressive, tensile, and flexural strength. Additionally, SFs can improve the mechanical properties of the mix as well as enhance its post-cracking and fatigue behavior. Adding both CNTs with SFs increased compressive, tensile, and flexural strength by 22.7%, 29.3%, and 70.8%, respectively, more than the traditional pavement.

Conclusion
This work found that combining SFs with CNTs improves the mechanical properties of the concrete mortar, resulting in a stronger mortar that can withstand more loads than the traditional one.
A Phase II, Two-Stage Study of Letrozole and Abemaciclib in Estrogen Receptor–Positive Recurrent Endometrial Cancer
Authors: Konstantinopoulos Panagiotis A. , Lee Elizabeth K. , Xiong Niya , Krasner Carolyn , Campos Susana , Kolin David L. , Liu Joyce F. , Horowitz Neil , Wright Alexi A. , Bouberhan Sara , Penson Richard T. , Yeku Oladapo , Bowes Brittany , Needham Hope , Hayes Martin , Sawyer Hannah , Polak Madeline , Shea Meghan , Cheng Su-Chun , Castro Cesar , Matulonis Ursula A. 
Published: September 2022

PURPOSE Estrogen receptor (ER)–positive endometrial cancers (ECs) are characterized by phosphatidylinositol 3-kinase (PI3K) and receptor tyrosine kinase (RTK)/RAS/β-catenin (CTNNB1) pathway alterations in approximately 90% and 80% of cases, respectively. Extensive cross-talk between ER, PI3K, and RTK/RAS/CTNNB1 pathways leads to both ligand-dependent and ligand-independent ER transcriptional activity as well as upregulation of cyclin D1 which, in complex with cyclin-dependent kinases 4 and 6 (CDK4 and CDK6), is a critical regulator of cell cycle progression and a key mediator of resistance to hormonal therapy. We hypothesized that the combination of the aromatase inhibitor letrozole and CDK4/6 inhibitor abemaciclib would demonstrate promising activity in this setting. METHODS We conducted a phase II, two-stage study of letrozole/abemaciclib in recurrent ER-positive EC. Eligibility criteria included measurable disease, no limit on prior therapies, and all EC histologies; prior hormonal therapy was allowed. Primary end points were objective response rate by RECIST 1.1 and progression-free survival (PFS) rate at 6 months. RESULTS At the data cutoff date (December 03, 2021), 30 patients (28 with endometrioid EC) initiated protocol therapy; 15 (50%) patients had prior hormonal therapy. There were nine total responses (eight confirmed), for an objective response rate of 30% (95% CI, 14.7 to 49.4), all in endometrioid adenocarcinomas. Median PFS was 9.1 months, PFS at 6 months was 55.6% (95% CI, 35.1 to 72), and median duration of response was 7.4 months. Most common ≥ grade 3 treatment-related adverse events were neutropenia (20%) and anemia (17%). Responses were observed regardless of grade, prior hormonal therapy, mismatch repair, and progesterone receptor status. Exploratory tumor profiling revealed several mechanistically relevant candidate predictors of response ( CTNNB1, KRAS, and CDKN2A mutations) or absence of response ( TP53 mutations), which require independent validation. CONCLUSION Letrozole/abemaciclib demonstrated encouraging and durable evidence of activity in recurrent ER positive endometrioid EC.
Prognostic Models for Traumatic Brain Injury Have Good Discrimination but Poor Overall Model Performance for Predicting Mortality and Unfavorable Outcomes
Authors: Eagle Shawn R. , Pease Matthew , Nwachuku Enyinna , Deng Hansen , Okonkwo David O. 
Published: September 2022

BACKGROUND:The most extensively validated prognostic models for traumatic brain injury (TBI) are the Corticoid Randomization after Significant Head Injury (CRASH) and International Mission on Prognosis and Analysis of Clinical Trials (IMPACT). Model characteristics outside of area under the curve (AUC) are rarely reported.OBJECTIVE:To report the discriminative validity and overall model performance of the CRASH and IMPACT models for prognosticating death at 14 days (CRASH) and 6 months (IMPACT) and unfavorable outcomes at 6 months after TBI.METHODS:This retrospective cohort study included prospectively collected patients with severe TBI treated at a single level I trauma center (n = 467). CRASH and IMPACT percent risk values for the given outcome were computed. Unfavorable outcome was defined as a Glasgow Outcome Scale-Extended score of 1 to 4 at 6 months. Binary logistic regressions and receiver operating characteristic analyses were used to differentiate patients from the CRASH and IMPACT prognostic models.RESULTS:All models had low R2values (0.17-0.23) with AUC values from 0.77 to 0.81 and overall accuracies ranging from 72.4% to 78.3%. Sensitivity (35.3-50.0) and positive predictive values (66.7-69.2) were poor in the CRASH models, while specificity (52.3-53.1) and negative predictive values (58.1-63.6) were poor in IMPACT models. All models had unacceptable false positive rates (20.8%-33.3%).CONCLUSION:Our results were consistent with previous literature regarding discriminative validity (AUC = 0.77-0.81). However, accuracy and false positive rates of both the CRASH and IMPACT models were poor.
An adherent-invasive Escherichia coli-colonized mouse model to evaluate microbiota-targeting strategies in Crohn's disease
Authors: Sivignon Adeline , Chervy Mélissa , Chevarin Caroline , Ragot Elia , Billard Elisabeth , Denizot Jérémy , Barnich Nicolas 
Published: September 2022

ABSTRACT
Adherent-invasive Escherichia coli (AIEC) were investigated for their involvement in the induction/chronicity of intestinal inflammation in Crohn's disease (CD). AIEC gut establishment is favoured by overexpression of the glycoprotein CEACAM6 in the ileal epithelium. We generated a transgenic mouse model, named ‘Vill-hCC6’, in which the human CEACAM6 gene was under the control of the villin promoter, conditioning expression in the small intestine. We demonstrated that CEACAM6 is strongly expressed in the small intestine mucosa and is correlated with numerous glycosylations displayed at the brush border of enterocytes. Ex vivo, the AIEC–enterocyte interaction was enhanced by CEACAM6 expression and necessitated the presence of the bacterial adhesive factor FimH. Finally, AIEC bacteria preferentially persisted in a FimH-dependent manner in the ileal mucosa of Vill-hCC6 mice compared to wild-type mice. This preclinical model opens new perspectives in the mechanistic study of the AIEC pathobiont and represents a valuable tool to evaluate the efficacy of new strategies to eliminate AIEC implanted in the ileal mucosa, such as phages, inhibitory and/or anti-virulence molecules, or CRISPR-based strategies targeting virulence or fitness factors of AIEC bacteria.