bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulation Optimization and Evaluation of Nanocochleate Gel of
Famciclovir for the Treatment of Herpes Zoster
Authors: Kanugo Abhishek , Deshpande Ashwini , Sharma Rahul 
Published: June 2022

Background:
Herpes zoster is a viral infection triggered due to the reactivation of the varicella-
zoster virus in the posterior dorsal root ganglion. Herpes zoster infections occur mostly in the facial,
cervical and thoracic regions of the body, beginning with pain and resulting in the vesicular eruption.
Recently, this infection was observed during the Covid-19 pandemic and also after the induction
of mRNA-based vaccine for coronavirus at an extended level. Nanocochleates are cylindrical (cigarshape)
microstructure lipid-based versatile carriers for drug delivery systems. Famciclovir is an antiviral
agent employed for the treatment of Herpes zoster infections.

Objective:
The current research aims to develop a novel nanocochleate gel of Famciclovir for the
treatment of herpes zoster infections with higher efficacy.

Methods:
The interaction studies using FTIR were carried out and indicated no such interactions between
the drug and lipids. The nanocochleates were developed using hydrogel, trapping, liposome before
cochleate dialysis, direct calcium dialysis and binary aqueous-aqueous emulsion methods, respectively.
The 32 Box-Behnken design was applied by considering the concentration of lipids (phosphatidylcholine
and cholesterol) and speed of rotation as independent factors, whereas particle size and entrapment
efficiency as dependable factors.

Results:
The developed nanocochleates were estimated for the particle size (276.3 nm), zeta potential
(-16.7 mV), polydispersity index (0.241), entrapment efficiency (73.87±0.19 %) and in-vitro diffusion
release (>98.8 % in 10 h). The optimized batch was further converted into the topical gel using carbopol
940 as a gelling agent. The prepared gel was smooth, rapidly spreadable with a viscosity (5998.72
cp), drug content (95.3 %) and remained stable during stability studies.

Conclusion:
A novel nanocochleate gel of Famciclovir was successfully developed for the treatment of
infections associated with Herpes Zoster with sustained release action.
Influence of Solid Particles on Wellbore Parameters in Solid Fluidization Production Process
Authors: Tang Liang , Liu Yang 
Published: June 2022

Objective:
To efficiently exploit the hydrate reservoir, based on the problem of a large
amount of sand production in the current hydrate reservoir exploration process, combined with the solid
fluidization well testing and production method.

Methods:
A gas-liquid-solid three-phase flow model is established and hydrate decomposition is taken
into consideration. The changes in parameters of wellbore pressure, gas volume fraction, liquid volume
fraction, temperature and the decomposition rates of wellbore hydrate under the conditions of different
rates of sand production are analyzed.

Results:
The results show that with the increasing rate of sand production during the solid fluidization
well testing and production, the pressure of the wellbore is lifted, gas volume fraction declines, liquid
volume fraction declines, and the temperature of the wellbore does not change. Moreover, increasing
the rate of sand production also leads to the delay of the position where hydrate begins to decompose.

Conclusion:
With the decrease in hydrate saturation, the pressure of the wellbore goes up, gas volume
fraction is lifted, solid volume fraction rises, and decomposition rate of hydrate declines.
Cyclooxygenase (COX) and 15-Lipoxygenase (15-LOX) Inhibitory Activity and HPTLC Profile of Asplenium Nidus, Diplazium Esculentum, and Drynaria Quercifolia in Bukidnon, Philippines
Authors: Ang Aileen May G. , Sabesaje Roxan D. , Barbosa Gina B. , Cruz Reggie Y. dela , Mendez Rainear A. , Enot Melania M. 
Published: June 2022

Diplazium esculentum, Drynaria quercifolia, and Asplenium nidus are among the fern species found in Bukidnon, Philippines which are used as traditional herbal medicines. The HPTLC profile and the anti-inflammatory properties against cyclooxygenase (COX) and 15-lipoxygenase (15-LOX) of the frond ethanolic extracts of D. esculentum, D. quercifolia, and A. nidus were determined. The High-Performance Thin Layer Chromatography (HPTLC) profile was obtained using ethyl acetate: formic acid: water (16:2:2) as mobile phase and Natural Products (NP) as derivatizing reagent. The HPTLC profile of the D. esculentum, D. quercifolia, and A. nidus extracts showed 10 (Rf = 0.02-0.97), 13 (Rf = 0.03-0.90), and 14 (Rf = 0.02-0.99) bands, respectively. The profiles for each fern species may be used as marker for quality evaluation and standardization of herbal formulations containing these plants. For the anti-inflammatory properties, D. esculentum and D. quercifolia extracts which inhibited more than 50% of the COX enzymes showed significantly higher activity than A. nidus and were considered active against COX-2 and COX-1. D. esculentum, however, gave a selectivity ratio (COX-2/COX-1) of 1.03 making its inhibitory activity selective against COX-2. The percent 15-LOX inhibitory activity of D. quercifolia (58.62%) is significantly higher than that of A. nidus (38.70%) but statistically comparable to D. esculentum (51.19%). Among the extracts, D. quercifolia and D. esculentum which inhibited more than 50% of the 15-LOX were considered active. D. esculentum and D. quercifolia can therefore be potential sources of anti-inflammatory lead compounds for future drug development.
Synthesis, Characterization and Invivo Evaluation of Poly Sulfoxy Amine Grafted Xanthan Gum
Authors: Rahul Laxman Jadhav  , Manisha Vyankatrao  Patil  , Shaikh Siraj N  
Published: June 2022

Natural polymers are hydrophilic in nature, economic, chemically inert, easily available, biodegradable, and non-toxic. Following problems associated with the use of gums include uncontrolled rates of hydration, pH dependent solubility, thickening, drop in viscosity on storage, and the possibility of microbial contamination. Chemical modification of gums not only minimizes these drawbacks but also alter their physicochemical properties. Recently, researchers have been modifying properties of natural gums to explore its more applicability. Aim of the current study was to explore Xanthan gum’s applicability in mucoadhesive and other property by doing its Chemical modification. Sulfoxy amine modification of xanthan gum was carried out by reacting xanthan gum with thionyl chloride and further treated with ammonia. FTIR, elemental DSC, XRD and SEM were studied for confirmation of the modification. The modified xanthan gum showed improvement in the mucoadhesion, water uptake capacity, gelling property as well as viscosity as compared to unmodified xanthan gum. The results of X-ray diffraction study confirms the finding of DSC study. X-ray diffractogram confirmed XG is typical of amorphous substance while that of MXG is typical of crystalline substance with the characteristic peak appearing at 14.79, 25.66, 29.63 and 31.82 2θ. The 0.6% w/v of modified xanthan gum showed gelling property. The 0.6% w/v of modified Xanthan Gum showed gelling property where as Xanthan Gum required more than 1% w/v , it indicate that gelling property of Xanthan Gum has improved due to its modification. Mucoadhesive strength of modified xanthan gum was found to be 4±0.56 gm which is more than xanthan gum i.e. 1.5±0.94 gm. The ionic interactions may be taken place in between negatively charged mucus with cationic modified polymer and superior mucoadhesion can be achieved. Rapid and constant swelling behavior was observed by modified Xanthan gum. The SEM image of MXG showed that the grafting of Polysulfoxyamine onto XG brings about the change in the shape and size of the XG particles. The enhanced viscosity and gelling capacity of modified xanthan gum were also observed as compared to xanthan gum. In vivo acute toxicity study of Poly sulfoxy amine grafted xanthan gum was performed. The toxicological effects were observed in terms of mortality and expressed as LD50. Results of Acute toxicity study shows LD50 value was more than 2 gm/kg indicating the low toxicity. These findings proved that modified xanthan gum may be used as promising excipient in various drug delivery systems.
Persepsi Wisatawan Tentang Wahana Olahraga Underwater di desa Bangsring Kabupaten Banyuwangi
Authors: Hanafi Rahma , Wahjoedi Wahjoedi , Semarayasa I ketut 
Published: June 2022

AbstrakPenelitan ini bertujuan untuk mengetahui persepsi wisatawan tentang wahana olahraga underwater di Desa Bangsring Kabupaten Banyuwangi. Jenis penelitain ini adalah jenis penelitian deskriptif kuantitatif, dengan menggunakan metode survey dengan teknik pengambilan data observasi, kuisioner dan dokumentasi. Populasi dalam penelitian ini adalah wisatawan yang berkunjung di wisata bangsring underwater dimana mereka yang telah menikmati wahana olahraga underwater. Analisis data yang digunakan dalam penelitian ini yaitu deskriptif kualitatif dengan persentase. Hasil dari penelitian ini menunjukkan bahwa (1) sumber informasi dan tujuan berkunjung memiliki persentase baik dengan 85%. (2) sarana dan prasarana pariwisata olahraga underwater memiliki persentase yang baik dengan 89%. (3) keunikan wahana olahraga underwater di desa bangsring memiliki persentase sangat baik yaitu 91,4%. (4)Jenis layanan wisata memiliki persentase cukup baik dengan 84%. (5) pengelolaan tempat wisata memiliki persentase cukup baik juga dengan 87,5%. Berdasarkan hasil dari analisis data dalam penelitian ini, maka dapat disimpulkan bahwa persepsi wisatawan tentang wahana olahraga underwater khususnya snorkeling dan diving di Desa Bangsring Kabupaten Banyuwangi dengan keseluruhan dapat dikatakan baik. Penelitian ini diharapkan menjadi acuan pengelola wisata bangsring underwater agar meningkatkan kualitas pengelolaan, pelayanan dan penambahan wahana baru agar menambah daya tarik wisatawan untuk berkunjung.
Spiritual and Moral Aspects of Family Education in the Romanov Dynasty
Authors: Marina Tokmacheva 
Published: June 2022

The article is devoted to the issue of family education in the royal dynasty of the Romanovs. The author analyzes the influence of the worldview paradigms dominating in the Russian society of the period under study – Western humanistic and Russian traditional, Orthodox – on the formation of the spiritual and moral qualities of the royal students, examines the tendencies of this pedagogical process and identifies its patterns.
Kerjasama Hindu-Islam Dalam Hubungan Antar Agama di Desa Kiluan Lampung
Authors: Zarkasi Ahmad , Ruslan Idrus , Rosana Ellya , Kalsum Afif Umi 
Published: June 2022

The actualization of the paradigm of cooperation between religious communities is the most important agenda for activists of inter-religious harmony, especially religious believers themselves. Especially for the people who live in a multi-religious area, because there is no religion teaches hatred in order to harmony between religious communities must be cared for and maintained well. In relations between religious communities, this is need for collective action in facing the challenges of the future of humanity, because of considering the reality of Indonesia which adheres to absolute multiculturalism. This research used field research to raise a phenomenon of cooperation between religious community in the village of Kiluan by used descriptive analysis techniques and direct interviews. The results of this study indicate that the cooperation carried out by the community is associative, namely the cooperative relationship that exists in every aspect of social life and also supported by government and local religious leader. In conclusion, if all the stake holders well cooperate in every social life, the paradigm of cooperation between religious communities is well actualized and fully tolerated.
The status of the image in ECE assessment practice
Authors: Gunn Alexandra C. , White E. Jayne , Williams Ngaroma 
Published: June 2022

While much has been done to advance narrative assessment practice in the early years, less attention has been granted to the role of the image in this pursuit. As a consequence, the purposes, value and strategic use of images (photographs, videos, visual metaphors etc.) in foregrounding learning of young children are not well understood. This paper reports on the results of a short pilot survey, sent to the early childhood education (ECE) sector Aotearoa New Zelaand in early February 2022, asking a series of exploratory questions about the status and utility of the image in ECE assessment. Images were not only viewed by many respondents as central to assessment and the co-production of knowledge about children’s learning, but they were also considered to be significant in terms of the trustworthiness and credibility of assessment information. Images represented young children’s learning in accessible ways and provided for reinterpretation, negotiation of meaning, and ongoing conversations about children’s changing experiences, capabilities, relationships, and community in ECE. As entry points to assessment dialogues with whānau and children, images provided a shared source of evidence about valued learning. We conclude with a provocation arising from understanding images as central to assessment that calls for more critical literacy concerning the placement and status of the image in ECE assessment practice – especially in light of assessment in the bicultural curriculum context of Te Whāriki (MoE, 2017).
The European Union Facing the 21st Century: The Digital Revolution
Authors: Troitiño David Ramiro 
Published: June 2022

Abstract
The European Union is a unique political process in the world. It continuously integrates different aspects creating a communality among its Member States. The process of integration responds to the necessities of the organization to adapt to the social, political, and economic reality and solving the dysfunctionalities arisen from the process. Currently, digitalization is a process required to adapt the European Union to the reality, to provide a common frame to an existing digital world. Therefore, the EU needs to respond the requirements of the society for the implementation of European standards in a new, but already relevant, area. In addition, the EU drag from the past dysfunctionalities that can be addressed thanks to the new possibilities generated by the digitalization of politics and economy. This research analyses both the necessity of adapting and solving previous obstacles under the prism of the available digital solutions.
Ethical Concerns of Direct-to-Consumer Genetic Tests
Authors: Farahani Fereshteh Shahrabi 
Published: June 2022

Abstract
The rapid development of technology is having an enormous effect on our lives. Emerging technological solutions offer new possibilities in various fields and on different levels, either for ordinary human beings or organisations and governments. However, the ethical implications of such technologies on our lives, our societies, are often not fully understood and require careful analysis. This article focuses on one type of such technologies, genetic tests available to the public, analysing the potential ethical concerns in these tests being directly provided to the consumers.
Digital Integrity: A Foundation for Digital Rights and the New Manifestation of Human Dignity
Authors: Vardanyan Lusine , Stehlík Václav , Kocharyan Hovsep 
Published: June 2022

Abstract
The article is devoted to the research of the problematic aspects and modern challenges of data protection in the digital age from the perspective of the digital integrity of the person. We believe that personal data cannot be effectively protected as components of digital integrity of the person in the context of regulation of a separate right to personal data protection, which, in its turn, acts more as a tool of market regulation rather than a classical fundamental right. We argue that the consideration of digital integrity as a new foundation for digital rights and as a new manifestation of the restrictive concept of human dignity may help increase the level of effective protection of the person in the digital sphere as well as properly cover the existing gaps in the protection of the digital rights of the person.
Visualizing Interesting Patterns in Cyber Threat Intelligence Using Machine Learning Techniques
Authors: Ejaz Sarwat , Noor Umara , Rashid Zahid 
Published: June 2022

Abstract
In an advanced and dynamic cyber threat environment, organizations need to yield more proactive methods to handle their cyber defenses. Cyber threat data known as Cyber Threat Intelligence (CTI) of previous incidents plays an important role by helping security analysts understand recent cyber threats and their mitigations. The mass of CTI is exponentially increasing, most of the content is textual which makes it difficult to analyze. The current CTI visualization tools do not provide effective visualizations. To address this issue, an exploratory data analysis of CTI reports is performed to dig-out and visualize interesting patterns of cyber threats which help security analysts to proactively mitigate vulnerabilities and timely predict cyber threats in their networks.
An Augmented UCAL Model for Predicting Trajectory and Location
Authors: Kadri Nesrine , Ellouze Ameni , Turki Sameh , Ksantini Mohamed 
Published: June 2022

Abstract
Predicting human mobility between locations plays an important role in a wide range of applications and services such as transportation, economics, sociology and other fields. Mobility prediction can be implemented through various machine learning algorithms that can predict the future trajectory of a user relying on the current trajectory and time, learning from historical sequences of locations previously visited by the user. But, it is not easy to capture complex patterns from the long historical sequences of locations. Inspired by the methods of the Convolutional Neural Network (CNN), we propose an augmented Union ConvAttention-LSTM (UCAL) model. The UCAL consists of the 1D CNN that allows capturing locations from historical trajectories and the augmented proposed model that contains an Attention technique with a Long Short-Term Memory (LSTM) in order to capture patterns from current trajectories. The experimental results prove the effectiveness of our proposed methodology that outperforms the existing models.
E-negotiation design and engineering
Authors: Grzegorz Kersten Gregory 
Published: June 2022

Abstract
This paper is an excerpt from a book by Gregory Kersten, which was not yet completed before his unexpected passing in May 2020. Following a note from Gregory’s family, the paper includes a section of a book chapter dealing with negotiation protocols. It shows how negotiation, as a purposeful process governed by explicit and implicit rules has protocols that can be employed to help negotiators orient themselves in this process. In particular, with respect to e-negotiations, the paper stresses the need to have a shared and clear understanding of the terms that are used by negotiators and software, which should be provided by taxonomy or ontology. The paper distinguishes three principal aspects of negotiations: decision and choice; language; and process. It also identifies key challenges related to the successful implementation of negotiation software agents.
Concession crossover in electronic negotiations
Authors: Carbonneau Real , Vahidov Rustam , Yu Bo 
Published: June 2022

Abstract
Negotiation is a joint decision making process involving making concessions by the parties. Concession-making may involve giving up negotiator’s utility and is an essential activity in the negotiation process. In the past it has been suggested by some authors that negotiators utility functions over the issues may not be linear. In this case, a phenomenon called “concession crossover” takes place, in which a negotiator may switch issues on which they choose to make concessions at some point in negotiations. This work sets to investigate the validity of such claims. To this end we introduce several concession-making models and use them for testing hypotheses. We have used a dataset from online negotiation experiments featuring a contract-signing case. The results support the claim that concession crossover does indeed occur.
The principal-agent problem in supply chain management – the simulation based framework
Authors: Siuta Kinga , Kaszyński Daniel 
Published: June 2022

Abstract
This research deals with a phenomenon well-known in socio-economic studies and referred to as the Agency Theory: the principal-agent problem. The agent is designated to act on behalf of the company owner, i.e., the principal, in the domain of supply chain management in the face of a supplier’s default uncertainty. Each of the players is gain-oriented, but their objective functions and the degree of risk-bearing may significantly differ, leading to an agent’s decisions not being optimal in terms of the principal’s outcome. This article proposes a multi-period supply chain simulation model that can be used to perform a supply chain optimization and comparison between the agent and the principal. The proposed framework allows for differentiating the model parametrization depending on the industry, in particular the consequences of the inability to deliver the end product, costs of keeping safety stocks, or the uncertainty regarding the suppliers’ delivery failure. As players’ objective functions, we consider expected profit-based indicators and measures taking the inter-period variance into account. We find that the agent’s actions may diverge from the principal’s optimum if the agent’s incentive system is not selected correctly. We also propose a solution that unifies the goals of the players. The recent COVID-19 pandemic amplifies the importance of such research. Many companies had to limit production capacities due to global lockdowns and, per the JIT production strategy, the prior safety stock levels were low.
Reforms of Czech Hospitals in Multiple Streams Perspective: The Cases of Success and Failure
Authors: Angelovská Olga , Novotný Vilém 
Published: June 2022

Abstract
The Czech Republic experienced a significant transformation of health care as a consequence of society-wide changes which started 30 years ago. The article aims to identify factors of successful and unsuccessful processes in giving a legislative anchor to the new organisational–legal form of Czech hospitals after 2000. There were several attempts to change the organisational–legal structure of hospitals. Just two of them succeeded to enter the decision-making phase in the Parliament, and only one led to successful approval of the Act.
In the article, we use the Multiple Stream Framework (MSF) to explain how different streams (policy, politics and problem stream) couple and open a policy window that allows a policy change. We chose modified MSF, which broadens the concept by including the agenda-setting as well as decision-making processes and offers two coupling processes. In a comparison of two cases of the policy process, we identified the factors that cause closing the window before the agenda is set.
How the Contagion is Transmitted to the Macedonian Stock Market? an Analysis of Co-Exceedances
Authors: Sulejmani Artan , Tevdovski Dragan 
Published: June 2022

Abstract
The aim of the paper is to analyze the transmission of shocks from selected developed and Southeastern European stock markets to the stock market of North Macedonia. Using the Bae, Karolyi, and Stulz (2003) co-exceedance methodology, we find that the probability of contagion from the stock markets of United States, Serbia and Bosnia and Herzegovina to the Macedonian stock market increased during the Global Financial Crisis. Regarding the asset classes, we show that contagion is positively associated with the volatility of Eurostoxx50 index, while negatively with the return of the euro dollar exchange rate and the yield of the 10-year US Treasury Note. The results have important implications for portfolio diversification and the asset allocation decisions of investors.