bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disability of non-academic employees in public universities: an exploration of daily work experiences
Authors: Mousa Mohamed 
Published: June 2022

PurposeThrough addressing non-academic disabled employees in seven public universities in Egypt, the author aims to find out the main struggles facing disabled non-academic employees in their work context pre and post Covid-19.Design/methodology/approachThe author employed a qualitative research method through semi-structured interviews with 28 disabled non-academic employees from seven universities in Egypt. The author subsequently used thematic analysis to determine the main ideas in the transcripts.FindingsThe author of the present paper has discovered the main struggles facing disabled non-academic employees in public universities in Egypt before and after the spread of Covid-19 and grouped them into the following three categories: macro-level struggles (government not serious about adopting a quota system, using disability quotas for political reasons, lack of understanding of the needs of disabled employees, poor infrastructure in work contexts), meso-level struggles (unaware of overqualified disabled employees, underrepresentation of disabled employees at senior administrative positions, assigning disabled employees unfair access to university resources) and micro-level struggles (disabled employees' lack of confidence in accepting promotion, inability of disabled employees to join informal networks and disabled employees' exposure to speech-related harassment).Originality/valueThis paper contributes by filling a gap in HR management and educational leadership, in which empirical studies on the struggles facing disabled non-academic employees in their work contexts have been limited so far.
Animosity, preference conflict and consumption context in an international crisis: a normative influence perspective
Authors: Fong Cher-Min , Chang Hsing-Hua Stella , Han Yu-Lin 
Published: June 2022

PurposeBecause of its omission of social influences, conventional animosity research has failed to sufficiently consider consumption context. To address this limitation, this research constitutes two interrelated parts: (a) investigating how normative influences (value-expressive and utilitarian influences) shape consumers’ animosity attitudes and purchase intentions; and (b) building on the normative influence perspective and separating consumption context into purchase (online vs. offline) and usage (private vs. public) contexts. The goal was to examine under the condition of preference conflict, how consumption contexts with different degrees of behavioral exposure affect purchase decisions.Design/methodology/approachOne pretest, one survey and one experiment were conducted to empirically validate the proposed research model.FindingsIn an international crisis, consumers’ attitudes and behaviors were socially determined. Moreover, the online purchase with private usage (offline purchase with public usage) condition resulted in the highest (lowest) level of purchase intention.Originality/valueThis research pioneers in the animosity literature to identify the possibility of preference conflict in a situational international crisis, and to more delicately separate the conventional consumption context into purchase and usage contexts.
Healthcare provider selection for elderly patients suffering from NCD's: an analysis with the combined approach of DEMATEL and AHP
Authors: Singh Ankit , Jha Ajeya , Purbey Shankar , Ravi Priya 
Published: June 2022

PurposeElderly patients suffering from non-communicable disease face a dilemma in the selection of healthcare providers. This study attempts to identify the key variables playing a crucial role and identify the appropriate healthcare destination with the help of a combination of Decision-making Trial and Evaluation Laboratory (DEMATEL) and analytic hierarchy process (AHP) techniques. The primary objective is to introduce the DEMATEL and AHP as efficient decision-making methods to choose the right healthcare provider for elderly patients suffering from non-communicable diseases.Design/methodology/approachAn integrative approach utilizing DEMATEL and AHP is used to reach the ideal solution for healthcare provider selection decisions. The DEMATEL approach is used to segregate the cause and effect variables. Similarly, the AHP is used to identify the weights of the top five cause-inducing variables, and the paired comparison method is used to select the healthcare provider.FindingsThe variables such as dependency on family members, easily accessible services, and patient autonomy play a vital role in the selection decision of healthcare providers in elderly patients suffering from non-communicable diseases.Practical implicationsIn terms of priority, home healthcare should be considered the preferred provider for elderly patients suffering from non-communicable diseases followed by neighbourhood registered medical practitioners and hospitals.Originality/valueThis is the first of its kind study which has attempted to solve the healthcare provider selection decision with the combined approach of DEMATEL and AHP.
Giving and taking ownership of a destination brand: mechanisms of stakeholder engagement
Authors: Tøttenborg Alberte , Ooi Can-Seng , Hardy Anne 
Published: June 2022

Purpose
This paper aims to explore the complexities of engaging with local stakeholders in destination branding. As the main creators and drivers of the destination brand, many brand authorities metaphorically “give ownership” of the brand to local stakeholders, for them to “take ownership” of it. This paper examines the inherent challenges of this process. In the Tasmanian destination branding process presented here, the Tasmanian authorities used best practices to generate a sense of ownership of the destination brand among local tourism businesses. Some players engaged, but many did not. The study shows the necessity to understand the dynamics between giving ownership of the brand and the various local tourism business stakeholders actually taking ownership.

Design/methodology/approach
This study looks at an Australian destination branding experience, namely, Tasmania’s “Go Behind the Scenery”. Primary data were gathered through 14 in-depth interviews with tourism operators, selected through a purposive sampling approach, based on their various levels of participation in the branding processes. The interviews aimed to understand how they variously engaged with the brand and processes of ownership.

Findings
This study shows that a relatively open interpretation of the brand can welcome wider engagement and generate a sense of ownership through the local businesses’ own interpretations. But there are also barriers for these stakeholders in developing an even stronger sense of ownership. They need more support in addressing their individual circumstance before the brand can align with their business.

Originality/value
This paper accentuates an ownership gap, understood as the gap between giving ownership (mechanisms to transfer ownership from brand authorities to stakeholders) and taking ownership (stakeholders assume responsibility for and manifest the brand). In identifying a gap between these two aspects of engagement, this paper initiates a more nuanced discussion on the mechanisms of stakeholder engagement in the branding process.
Tourist scams, moral emotions and behaviors: impacts on moral emotions, dissatisfaction, revisit intention and negative word of mouth
Authors: Ma Jianan , Li Fangxuan (Sam) , Shang Yuanyuan 
Published: June 2022

Purpose
Drawing upon affective events theory (AET), this study aims to explore the relationship between tourists’ perceived deception and moral emotions, dissatisfaction, revisit intention and negative word of mouth.

Design/methodology/approach
Online data from Questionnaire Star were used to examine the proposed research model. A total of 437 valid questionnaires were collected.

Findings
The results suggest that tourist scams as “affective events” could trigger tourists’ moral emotions and dissatisfaction, thereby decreasing their revisit intention and generating negative word of mouth. Additionally, moral emotions were found to act as a mediator between perceived deception and dissatisfaction.

Research limitations/implications
The insights uncovered in this study reveal the mechanisms behind tourists’ reactions to scams and provide implications for tourism destinations, suggesting ways to alleviate the adverse impact of tourist scams.

Originality/value
To the best of the authors’ knowledge, this is the very first study to investigate tourists’ reactions to tourist scams.
Dihydroartemisinin protects blood–brain barrier permeability during sepsis by inhibiting the transcription factor SNAI1
Authors: Liu Fuhong , Liu Jing , Xiang Hongjie , Sun Zongguo , Li Yan , Li Xiao , Liu Yanjun , Liu Ju 
Published: June 2022

AbstractBlood–brain barrier (BBB) injury is involved in the pathogenesis of sepsis‐associated encephalopathy. In this study, we used dihydroartemisinin (DHA), a derivative of artemisinin, to treat a cecal ligation and puncture (CLP)‐induced mouse sepsis model and a tumour necrosis factor α (TNF‐α)‐stimulated human cerebral microvessel endothelial cells (hCMEC)/D3 cell line. We found that DHA decreased BBB permeability and increased the expression of the tight junction protein occludin (OCLN) in the CLP model. In hCMEC/D3 cells, DHA decreased TNF‐α‐induced hyperpermeability and increased the expression of OCLN. DHA also repressed SNAI1 expression in the CLP mouse model and in TNF‐α‐stimulated hCMEC/D3 cells. These data suggest that DHA protects BBB permeability during sepsis by stimulating the expression of OCLN, by downregulating the expression of the SNAI1 transcription factor.
A high‐fat diet changes astrocytic metabolism to promote synaptic plasticity and behavior
Authors: Popov Alexander , Brazhe Nadezda , Fedotova Anna , Tiaglik Alisa , Bychkov Maxim , Morozova Kseniia , Brazhe Alexey , Aronov Dmitry , Lyukmanova Ekaterina , Lazareva Natalia , Li Li , Ponimaskin Evgeni , Verkhratsky Alexei , Semyanov Alexey 
Published: June 2022

AbstractAimA high‐fat diet (HFD) is generally considered to negatively influence the body, the brain, and cognition. Nonetheless, fat and fatty acids are essential for nourishing and constructing brain tissue. Astrocytes are central for lipolysis and fatty acids metabolism. We tested how HFD affects astrocyte metabolism, morphology, and physiology.MethodsWe used Raman microspectroscopy to assess the redox state of mitochondria and lipid content in astrocytes and neurons in hippocampal slices of mice subjected to HFD. Astrocytes were loaded with fluorescent dye through patch pipette for morphological analysis. Whole‐cell voltage‐clamp recordings were performed to measure transporter and potassium currents. Western blot analysis quantified the expression of astrocyte‐specific proteins. Field potential recordings measured the magnitude of long‐term potentiation (LTP). Open filed test was performed to evaluate the effect of HFD on animal behavior.ResultsWe found that exposure of young mice to 1 month of HFD increases lipid content and relative amount of reduced cytochromes in astrocytes but not in neurons. Metabolic changes were paralleled with an enlargement of astrocytic territorial domains due to an increased outgrowth of branches and leaflets. Astrocyte remodeling was associated with an increase in expression of ezrin and with no changes in glial fibrillary acidic protein (GFAP), glutamate transporter‐1 (GLT‐1), and glutamine synthetase (GS). Such physiological (non‐reactive) enlargement of astrocytes in the brain active milieu promoted glutamate clearance and LTP and translated into behavioral changes.ConclusionDietary fat intake is not invariably harmful and might exert beneficial effects depending on the biological context.
AZD8233 antisense oligonucleotide targeting PCSK9 does not prolong QT interval
Authors: Rekić Dinko , Azarov Ivan , Knöchel Jane , Sokolov Victor , Nilsson Catarina , Wernevik Linda , Han David , Rydén‐Bergsten Tina , Ebrahimi Ahmad , Dota Corina , Carlsson Björn 
Published: June 2022

AimsAZD8233 is a proprotein convertase subtilisin/kexin type 9 (PCSK9) antisense oligonucleotide under development for treatment of hypercholesterolaemia. A prespecified concentration‐QT analysis was performed based on data from a single ascending dose study that was prospectively designed to act as a TQT study substitute.MethodsSubcutaneous single doses ranging from 4 to 120 mg were evaluated in 73 adult healthy male subjects. Time‐matched 12‐lead digital ECG and plasma concentrations (n = 15) were measured at baseline and up to 48 hours after dose in each subject. The analysis was performed using a linear mixed effect model, where change from baseline QTc (ΔQTc) was a dependent variable and time‐matched AZD8233 concentration was an independent variable.ResultsThe high clinical exposure scenario was defined as 1.7‐fold the expected Cmax following an assumed therapeutic dose of 60 mg, which corresponds to AZD8233 plasma concentration of 1.39 μg/mL. Estimated placebo‐corrected and baseline‐adjusted QTcF interval (ΔΔQTcF) at this concentration was −2.2 ms (90% CI: −4.11, −0.28). Furthermore, the upper 90% ΔΔQTcF confidence interval was estimated to be below 10 ms at all observed concentrations.ConclusionAs the effect on ΔΔQTcF is below the threshold for regulatory concern (10 ms), it can be concluded that AZD8233 does not induce QTcF prolongation at the high clinical exposure scenario.
Phenological trajectories of Caribbean very dry tropical forests diverge under different geologic formations
Authors: Restrepo Carla , Delgado Diana , Debrot Adolphe O. , de Vries Albert J. , Houtepen Erik , de Freitas John A. 
Published: June 2022

AbstractTropical dry forests experience pronounced seasonal changes in precipitation manifested in varied plant phenologies. At landscape scales, geologic substrate—one of the least understood abiotic factors interacting with precipitation—may modulate phenological responses in these forests through a combination of mechanisms regulating water and nutrient use. We leveraged a phenological dataset from the semiarid island of Curaçao to examine the extent to which plant phenology at multiple levels of biological organization diverge under different geologies. Monthly observations over a 30‐month period of leaves, flowers, and fruits of 69 plant species of different life forms at three nearby sites differing in their underlaying geology were used to examine intra‐ and inter‐annual plant responses at species, community, and system levels. The integration of leaf, flower, and fruit observations at intra‐annual scales revealed diverse phenological strategies among species, broad associations with geologic substrate, and the extent of intra‐specific variation as a function of geology. The community‐ and system‐level analyses at inter‐annual scales showed a reduction in mean leaf scores during the 30‐month period, a weak and strong leafless period in 1993 and 1994, respectively, and differences among geologic substrates. Finally, we observed significant and positive relationships between precipitation and the phenophase scores; the strength of the relationships varied with phenophase and geologic substrate. Results of this work emphasize the importance of geologic substrate, and more broadly speaking landscape heterogeneity, in modulating plant phenological responses in tropical dry forests. Ultimately, this information will become important to understand and mitigate global climate change impacts.Abstract in Spanish is available with online material.
Recognizing precarity? A comparative analysis of governmental documents in provincial and federal administrations
Authors: Marier Patrik , Grenier Amanda , Kobayashi Karen , Rudman Debbie , Garcia‐Poulin Yoana , Hatzifilalithis Stephanie , Phillipson Chris 
Published: June 2022

AbstractWith an aging population, have federal and provincial governments acknowledged the diversity of the policy needs of older adults? This contribution analyzes administrative and policy documents across ministries to study the frequency and the depth of engagement involving older adults with a disability, older immigrants, and those living in poverty. Precarity received marginal treatment with very limited discussions combining aging in relation to disability, immigration and migration, or poverty. Most documents focused on poverty. Disability and aging are discussed in parallel and rarely in conjunction with aging. These findings suggest a low level of priority for precarity and aging.
Citizen satisfaction with public service delivery: A test of alternative theories
Authors: Reddick Christopher G. , Perlman Bruce J. , Demir Tansu 
Published: June 2022

AbstractTwo prevailing theories explain citizen satisfaction with public services from different levels and sizes of government. Reform theory argues that citizens derive the most satisfaction from larger government units because of economies of scale in service delivery. Political economy theory argues that citizens achieve the most satisfaction from smaller local government units since their voice is more likely to be heard. Both theories have been tested yielding mixed findings. An alternative theory argues that citizens have different levels of satisfaction depending upon the specific services received and directly experienced. These theories are tested using Canadian national public opinion survey data.
Biobanking of human pluripotent stem cells in China
Authors: Stacey Glyn Nigel , Hao Jie 
Published: June 2022

AbstractIn recent years, significant progress has been made internationally in the development of human pluripotent stem cell (hPSC)‐derived products for serious and widespread disorders. Biobanking of the cellular starting materials is a crucial component in the delivery of safe and regulatory compliant cell therapies. In China, key players in these developments have been the recently launched National Stem Cell Resource Center (NSCRC) and its partner organizations in Guangzhou and Shanghai who together, have more than 600 hPSC lines formally recorded in the Chinese Ministry of Science and Technology's stem cell registry. In addition, 47 of these hPSCs have also been registered with the hPSCreg project which means they are independently certified for use in European Commission funded research projects. The NSCRC are currently using their own cell lines to manufacture eight different cell types qualified for clinical use, that are being used in nine clinical studies for different indications. The Institute of Zoology at the Chinese Academy of Sciences (IOZ‐CAS) has worked with NSCRC to establish Chinese and international standards in stem cell research. IOZ‐CAS was also a founding partner in the International Stem Cell Banking Initiative which brings together key stem cell banks to agree minimum standards for the provision of pluripotent stem cells for research and clinical use. Here, we describe recent developments in China in the establishment of hPSCs for use in the manufacture of cell therapies and the significant national and international coordination which has now been established to promote the translation of Chinese hPSC‐based products into clinical use according to national and international standards.
Nitrogen input enhances microbial carbon use efficiency by altering plant–microbe–mineral interactions
Authors: Feng Xuehui , Qin Shuqi , Zhang Dianye , Chen Pengdong , Hu Jie , Wang Guanqin , Liu Yang , Wei Bin , Li Qinlu , Yang Yuanhe , Chen Leiyi 
Published: June 2022

AbstractMicrobial growth and respiration are at the core of the soil carbon (C) cycle, as these microbial physiological performances ultimately determine the fate of soil C. Microbial C use efficiency (CUE), a critical metric to characterize the partitioning of C between microbial growth and respiration, thus controls the sign and magnitude of soil C‐climate feedback. Despite its importance, the response of CUE to nitrogen (N) input and the relevant regulatory mechanisms remain poorly understood, leading to large uncertainties in predicting soil C dynamics under continuous N input. By combining a multi‐level field N addition experiment with a substrate‐independent 18O‐H2O labelling approach as well as high‐throughput sequencing and mineral analysis, here we elucidated how N‐induced changes in plant–microbial–mineral interactions drove the responses of microbial CUE to N input. We found that microbial CUE increased significantly as a consequence of enhanced microbial growth after 6‐year N addition. In contrast to the prevailing view, the elevated microbial growth and CUE were not mainly driven by the reduced stoichiometric imbalance, but strongly associated with the increased soil C accessibility from weakened mineral protection. Such attenuated organo–mineral association was further linked to the N‐induced changes in the plant community and the increased oxalic acid in the soil. These findings provide empirical evidence for the tight linkage between mineral‐associated C dynamics and microbial physiology, highlighting the need to disentangle the complex plant–microbe–mineral interactions to improve soil C prediction under anthropogenic N input.
Investigating immunoregulatory effects of myeloid cell autophagy in acute and chronic inflammation
Authors: Hasnat Md Abul , Cheang IanIan , Dankers Wendy , Lee Jacinta PW , Truong Lynda M , Pervin Mehnaz , Jones Sarah A , Morand Eric F , Ooi Joshua D , Harris James 
Published: June 2022

AbstractStudies have highlighted a critical role for autophagy in the regulation of multiple cytokines. Autophagy inhibits the release of interleukin (IL)‐1 family cytokines, including IL‐1α, IL‐1β and IL‐18, by myeloid cells. This, in turn, impacts the release of other cytokines by myeloid cells, as well as other cells of the immune system, including IL‐22, IL‐23, IL‐17 and interferon‐γ. Here, we assessed the impact of genetic depletion of the autophagy gene Atg7 in myeloid cells on acute and chronic inflammation. In a model of acute lipopolysaccharide‐induced endotoxemia, loss of autophagy in myeloid cells resulted in increased release of proinflammatory cytokines, both locally and systemically. By contrast, loss of Atg7 in myeloid cells in the Lyn−/− model of lupus‐like autoimmunity resulted in reduced systemic release of IL‐6 and IL‐10, with no effects on other cytokines observed. In addition, Lyn−/− mice with autophagy‐deficient myeloid cells showed reduced expression of autoantibodies relevant to systemic lupus erythematosus, including anti‐histone and anti‐Smith protein. In vitro, loss of autophagy, through pharmacological inhibition or small interfering RNA against Becn1, inhibited IL‐10 release by human and mouse myeloid cells. This effect was evident at the level of Il10 messenger RNA expression. Our data highlight potentially important differences in the role of myeloid cell autophagy in acute and chronic inflammation and demonstrate a direct role for autophagy in the production and release of IL‐10 by macrophages.