bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiplatelet therapy discontinuation after stent-assisted coil embolization for intracranial aneurysms: a single-center, long-term, retrospective, observational study
Authors: Goto Shunsaku , Izumi Takashi , Nishihori Masahiro , Imai Tasuku , Araki Yoshio , Kanamori Fumiaki , Uda Kenji , Yokoyama Kinya , Saito Ryuta 
Published: August 2022

OBJECTIVE
The protocol for antiplatelet therapy after stent-assisted coil embolization (SACE) for intracranial aneurysms is not well established. In particular, the indications for single antiplatelet therapy (SAPT) discontinuation remain controversial. The authors investigated the long-term outcomes of SAPT discontinuation after SACE among patients at a single institution.

METHODS
Patients who underwent SACE during the period from 2010 to 2020 and who were followed up for > 1 year were included in this study. The delayed ischemic and hemorrhagic complication rates were examined during follow-up. Moreover, the risk factors of antiplatelet therapy reduction or discontinuation and the outcomes of SAPT discontinuation were examined.

RESULTS
In total, 240 patients were included in the analysis. The average patient age was 60.3 years, and the average follow-up period was 46.7 months. Nine (3.8%) patients presented with symptomatic delayed ischemic complication, and 3 (1.3%) patients experienced a decline in modified Rankin Scale score. The stent configuration (T- or Y-stent) was the only risk factor associated with delayed ischemic complication (p < 0.001). SAPT was discontinued in 147 (71.7%) of 205 patients who were followed up for > 2 years, and no ischemic complications were observed.

CONCLUSIONS
It is safe to discontinue SAPT in patients without ischemic complications and with stable intraaneurysmal signals on MRA 2 years after SACE. The T- or Y-stent is a high-risk factor for delayed ischemic complications, and antiplatelet therapy reduction or discontinuation should be cautiously considered.
Intraarterial encephalography from an acutely implanted aneurysm embolization device in awake humans
Authors: Li Luyuan , Ibayashi Kenji , Piscopo Anthony , Deifelt Streese Carolina , Chen Haiming , Greenlee Jeremy D. W. , Hasan David M. 
Published: August 2022

OBJECTIVE
Endovascular electroencephalography (evEEG) uses the cerebrovascular system to record electrical activity from adjacent neural structures. The safety, feasibility, and efficacy of using the Woven EndoBridge Aneurysm Embolization System (WEB) for evEEG has not been investigated.

METHODS
Seventeen participants undergoing awake WEB endovascular treatment of unruptured cerebral aneurysms were included. After WEB deployment and before detachment, its distal deployment wire was connected to an EEG receiver, and participants performed a decision-making task for 10 minutes. WEB and scalp recordings were captured.

RESULTS
All patients underwent successful embolization and evEEG with no complications. Event-related potentials were detected on scalp EEG in 9/17 (53%) patients. Of these 9 patients, a task-related low-gamma (30–70 Hz) response on WEB channels was captured in 8/9 (89%) cases. In these 8 patients, the WEB was deployed in 2 middle cerebral arteries, 3 anterior communicating arteries, the terminal internal carotid artery, and 2 basilar tip aneurysms. Electrocardiogram artifact on WEB channels was present in 12/17 cases.

CONCLUSIONS
The WEB implanted within cerebral aneurysms of awake patients is capable of capturing task-specific brain electrical activities. Future studies are warranted to establish the efficacy of and support for evEEG as a tool for brain recording, brain stimulation, and brain-machine interface applications.
Dissociation of Broca’s area from Broca’s aphasia in patients undergoing neurosurgical resections
Authors: Andrews John P. , Cahn Nathan , Speidel Benjamin A. , Chung Jason E. , Levy Deborah F. , Wilson Stephen M. , Berger Mitchel S. , Chang Edward F. 
Published: August 2022

OBJECTIVE
Broca’s aphasia is a syndrome of impaired fluency with retained comprehension. The authors used an unbiased algorithm to examine which neuroanatomical areas are most likely to result in Broca’s aphasia following surgical lesions.

METHODS
Patients were prospectively evaluated with standardized language batteries before and after surgery. Broca’s area was defined anatomically as the pars opercularis and triangularis of the inferior frontal gyrus. Broca’s aphasia was defined by the Western Aphasia Battery language assessment. Resections were outlined from MRI scans to construct 3D volumes of interest. These were aligned using a nonlinear transformation to Montreal Neurological Institute brain space. A voxel-based lesion-symptom mapping (VLSM) algorithm was used to test for areas statistically associated with Broca’s aphasia when incorporated into a resection, as well as areas associated with deficits in fluency independent of Western Aphasia Battery classification. Postoperative MRI scans were reviewed in blinded fashion to estimate the percentage resection of Broca’s area compared to areas identified using the VLSM algorithm.

RESULTS
A total of 289 patients had early language evaluations, of whom 19 had postoperative Broca’s aphasia. VLSM analysis revealed an area that was highly correlated (p < 0.001) with Broca’s aphasia, spanning ventral sensorimotor cortex and supramarginal gyri, as well as extending into subcortical white matter tracts. Reduced fluency scores were significantly associated with an overlapping region of interest. The fluency score was negatively correlated with fraction of resected precentral, postcentral, and supramarginal components of the VLSM area.

CONCLUSIONS
Broca’s aphasia does not typically arise from neurosurgical resections in Broca’s area. When Broca’s aphasia does occur after surgery, it is typically in the early postoperative period, improves by 1 month, and is associated with resections of ventral sensorimotor cortex and supramarginal gyri.
Functional hemispherotomy for epilepsy in the very young
Authors: Pepper Joshua , Lo William B. , Agrawal Shakti , Mohamed Rana , Horton Jo , Balloo Selina , Philip Sunny , Basnet Ashish , Wimalachandra Welege Samantha Buddhika , Lawley Andrew , Seri Stefano , Walsh A. Richard 
Published: August 2022

OBJECTIVE
Epilepsy is one of the most common neurological disorders in children. Among very young children, one-third are resistant to medical treatment, and lack of effective treatment may result in adverse outcomes. Although functional hemispherotomy is an established treatment for epilepsy, its outcome in the very young child has not been widely reported. In this study the authors investigated seizure and developmental results after hemispherotomy in children younger than 3 years.

METHODS
The authors reviewed a prospective database of all children younger than 3 years with medically intractable epilepsy who underwent functional hemispherotomy at the authors’ institution during the period between 2012 and 2020. Demographic data, epilepsy history, underlying etiology, operative and transfusion details, and seizure and developmental outcomes were analyzed.

RESULTS
Twelve patients were included in this study. The mean age (± SD) at seizure onset was 3 ± 2.6 months and at surgery was 1.3 ± 0.77 years, with a mean follow-up of 4 years. Diagnoses included hemimegalencephaly (n = 5), hemidysplasia (n = 2), hypoxic/hemorrhagic (n = 2), traumatic (n = 1), Sturge-Weber syndrome (n = 1), and mild hemispheric structural abnormality with EEG/PET correlates (n = 1). Eleven patients achieved an Engel class I outcome, and 1 patient achieved Engel class IV at last follow-up. No deaths, infections, cerebrovascular events, or unexpected long-term neurological deficits were recorded. All children progressed neurodevelopmentally following surgery, but their developmental levels remained behind their chronological age, with an overall mean composite Vineland Adaptive Behavior Scale score of 58 (normal: 86–114, low: < 70). One patient required insertion of a subdural peritoneal shunt, 1 patient required dural repair for a CSF fluid leak, and 1 patient required aspiration of a pseudomeningocele. In 2 patients, both of whom weighed less than 5.7 kg, the first operation was incomplete due to blood loss.

CONCLUSIONS
Hemispherotomy in children younger than 3 years offers excellent seizure control and an acceptable risk-to-benefit ratio in well-selected patients. Families of children weighing less than 6 kg should be counseled regarding the possibility of staged surgery. Postoperatively, children continue to make appropriate, despite delayed, developmental progress.
Sensorimotor outcomes after resection for perirolandic drug-resistant epilepsy: a systematic review and individual patient data meta-analysis
Authors: Shlobin Nathan A. , Wang Andrew , Phillips H. Westley , Yan Han , Ibrahim George M. , Elkaim Lior M. , Wang Shuang , Liu Xiaoyan , Cai Lixin , Nguyen Dang K. , Fallah Aria , Weil Alexander G. 
Published: August 2022

OBJECTIVE
The prevalence of long-term postoperative sensorimotor deficits in children undergoing perirolandic resective epilepsy surgery is unclear. The risk of developing these deficits must be weighed against the potential reduction in seizure frequency after surgery. In this study, the authors investigated the prevalence of sensorimotor deficits after resective surgery at ≥ 1 year postoperatively.

METHODS
A systematic review and individual patient data meta-analysis was conducted using PubMed, Embase, and Scopus databases. Subgroups of patients were identified and categorized according to their outcomes as follows: group A patients were denoted as seizure free with no postoperative sensorimotor deficits; group B patients experienced seizure recurrence with no deficit; group C patients were seizure free with deficits; and group D patients were not seizure free and with deficits. Rates of sensory deficits were examined in patients undergoing postcentral gyrus resection, and rates of motor deficits were aggregated in patients undergoing precentral gyrus resection.

RESULTS
Of 797 articles resulting from the database searches, 6 articles including 164 pediatric patients at a mean age of 7.7 ± 5.2 years with resection for drug-resistant perirolandic epilepsy were included in the study. Seizure freedom was observed in 118 (72.9%) patients at a mean follow-up of 3.4 ± 1.8 years. In total, 109 (66.5%) patients did not develop sensorimotor deficits at last follow-up, while 55 (33.5%) had permanent deficits. Ten (14.3%) of 70 patients with postcentral gyrus resection had permanent sensory deficits. Of the postcentral gyrus resection patients, 41 (58.6%) patients were included in group A, 19 (27.1%) in group B, 7 (10.0%) in group C, and 3 (4.3%) in group D. Forty (37.7%) of 106 patients with precentral resections had permanent motor deficits. Of the precentral gyrus resection patients, 50 (47.2%) patients were in group A, 16 (15.1%) in group B, 24 (22.6%) in group C, and 16 (15.1%) in group D. Patients without focal cortical dysplasia were more likely to have permanent motor deficits relative to those with focal cortical dysplasia in the precentral surgery cohort (p = 0.02).

CONCLUSIONS
In total, 58.6% of patients were seizure free without deficit, 27.1% were not seizure free and without deficit, 10.0% were seizure free but with deficit, and 4.3% were not seizure free and with deficit. Future studies with functional and quality-of-life data, particularly for patients who experience seizure recurrence with no deficits (as in group B in the present study) and those who are seizure free with deficits (as in group C) after treatment, are necessary to guide surgical decision-making.
Endoscopic strip craniectomy with molding helmet therapy versus spring-assisted cranioplasty for nonsyndromic single-suture sagittal craniosynostosis: a systematic review
Authors: Valetopoulou Alexandra , Constantinides Maria , Eccles Simon , Ong Juling , Hayward Richard , Dunaway David , Jeelani Noor ul Owase , James Greg , Silva Adikarige Haritha Dulanka 
Published: August 2022

OBJECTIVE
Endoscopic strip craniectomy with postoperative molding helmet therapy (ESC-H) and spring-assisted cranioplasty (SAC) are commonly used minimally invasive techniques for correction of nonsyndromic sagittal craniosynostosis, but it is unclear which, if either, is superior. Therefore, the authors undertook a systematic review to compare ESC-H with SAC for the surgical management of nonsyndromic single-suture sagittal craniosynostosis.

METHODS
Studies were identified through a systematic and comprehensive search of four databases (Embase, MEDLINE, and two databases in the Cochrane Library). Databases were searched from inception until February 19, 2021. Pediatric patients undergoing either ESC-H or SAC for the management of nonsyndromic single-suture sagittal craniosynostosis were included. Systematic reviews and meta-analyses, single-patient case reports, mixed cohorts of nonsyndromic and syndromic patients, mixed cohorts of different craniosynostosis types, and studies in which no outcomes of interest were reported were excluded. Outcomes of interest included reoperations, blood transfusion, complications, postoperative intensive care unit (ICU) admission, operative time, estimated blood loss, length of hospital stay, and cephalic index. Pooled summary cohort characteristics were calculated for each outcome of interest. Methodological quality was assessed using the Newcastle-Ottawa Scale. The study was reported in accordance with the 2020 PRISMA statement.

RESULTS
Twenty-two studies were eligible for inclusion in the review, including 1094 patients, of whom 605 (55.3%) underwent ESC-H and 489 (44.7%) underwent SAC for nonsyndromic sagittal craniosynostosis. There was no difference between the pooled estimates of the ESC-H and SAC groups for operative time, length of stay, estimated blood loss, and cephalic index. There was no difference between the groups for reoperation rate and complication rate. However, ESC-H was associated with a higher blood transfusion rate and higher postoperative ICU admission.

CONCLUSIONS
The available literature does not demonstrate superiority of either ESC-H or SAC, and outcomes are broadly similar for the treatment of nonsyndromic sagittal craniosynostosis. However, the evidence is limited by single-center retrospective studies with low methodological quality. There is a need for international multicenter randomized controlled trials comparing both techniques to gain definitive and generalizable data.
PENGARUH KONDISI TANAH TERHADAP TAHANAN PENTANAHAN KAKI MENARA 150KV KRAMASAN-MARIANA
Authors: Nurdiana Nita , Radeli Rieski 
Published: August 2022

The grounding system is intended to ensure that both electrical equipment and the people around it are in a safe condition from overcurrent faults by transferring the fault current to earth. Electrode implantation is one of the factors to get a small grounding resistance value. This study aims to determine the effect of soil conditions on the value of grounding resistance at the foot of the Menara. By using the three-point method on three types of soil conditions at 6 feet Menara, the lowest grounding value is 5.12 ohms in the swamp area at Menara 10 location. The highest grounding resistance in the garden area is 8.32 ohm at Menara 66 location. All values the grounding resistance is in good condition and does not exceed the 150 Kilo Volt high voltage overhead line grounding standard, which is 10 ohms. From the results of the analysis, it is concluded that the soil conditions where the electrodes are implanted affect the grounding value ABSTRAKSistem pentanahan dimaksudkan untuk memastikan bahwa baik peralatan listrik maupun orang-orang disekitarnya dalam kondisi yang aman dari gangguan arus lebih dengan cara mentransfer arus gangguan ke bumi. Penanaman elektroda merupakan salah satu faktor untuk mendapatkan nilai hambatan pentanahan yang kecil. Penelitian ini bertujuan untuk mengetahui pengaruh kondisi tanah terhadap nilai tahanan pentanahan pada kaki Menara SUTT. Dengan menggunakan metode tiga titik pada tiga jenis kondisi tanah pada 6 kaki Menara, didapatkan nilai pentanahan terendah sebesar 5,12 ohm di daerah rawa pada lokasi Menara 10. Hambatan pembumpentanahan tertinggi di daerah kebun yaitu 8,32 ohm pada lokasi Menara 66. Semua nilai tahanan pentanahan dalam keadaan baik dan tidak melebihi standar pentanahan saluran udara tegangan tinggi 150 Kilo Volt yaitu sebesar 10 ohm. Dari hasil analisa diperoleh kesimpulan bahwa kondisi tanah dimana elektroda ditanamkan mempengaruhi nilai pentanahan.
MEDIATING ROLE OF JOB SATISFACTION IN RELATIONSHIP BETWEEN RETENTION, COMMITMENT, COMPETENCE IN IMPROVING PERFORMANCE
Authors: Santika Reva Ragam , Liswandi Liswandi , Hidayah Zainur 
Published: August 2022

This Study aims to investigate the effect of retention, commitment competence on lecturer performance through job satisfaction as moderating variable. Furthermore, The design of this research was survey research with a web-based cross-sectional data type. The research focuses on lecturers at one of the private university in Jakarta and the 136 sample was taken using the purposive sampling method. Data processing and hypothesis testing using the Multivariate Structural Equation Model (SEM) technique. The Research indicates that retention and competence have a positive but not significant influence on job satisfaction, while commitment has a significant positive influence on job satisfaction and competence has a significant positive influence on performance. In particular, the moderating influence of job satisfaction does not have a significant influence on the relationship between retention, commitment, and competence on lecturer performance The Conclusion of this study that retention, competence have positive effect but not significant on job satisfaction, competence has positive significant on Lecturer Performance and lecturer commitment has positive significant on job satisfaction but doesn’t have significant effect to Lecturer performance
Radiosynthesis and First Preclinical Evaluation of the Novel 11C-Labeled FAP Inhibitor 11C-FAPI: A Comparative Study of 11C-FAPIs and (68Ga) Ga-DOTA-FAPI-04 in a High–FAP-Expression Mouse Model
Authors: Wang Cheng , Hu Zhoumi , Ding Fan , Zhao Haitao , Du Fuqiang , Lv Chun , Li Lianghua , Huang Gang , Liu Jianjun 
Published: August 2022

Purpose: 68Ga-labeled fibroblast activation protein inhibitors, such as [68Ga]Ga-DOTA-FAPI-04 and [68Ga]Ga-DOTA-FAPI-46, have been successfully applied in positron emission tomography imaging of various tumor types. To broaden the PET tracers of different positron nuclides for imaging studies of FAP-dependent diseases, we herein report the radiosynthesis and preclinical evaluation of two 11C-labeled FAP inhibitors, 11C-RJ1101 and 11C-RJ1102. Methods: Two phenolic hydroxyl precursors based on a quinoline amide core coupled with a 2-cyanopyrrolidine moiety were coupled with [11C]CH3I to synthesize 11C-RJ1101 and 11C-RJ1102. In vivo small-animal PET and biological distribution studies of 11C-RJ1101 and 11C-RJ1102 compared to [68Ga]Ga-DOTA-FAPI-04 were conducted in nude mice bearing U87MG tumor xenografts at 30, 60, and 90min, respectively. Results: 11C-RJ1101 and 11C-RJ1102 were synthesized in over 15% radiochemical yields, with specific activities of 67 GBq/μmol and 34 GBq/μmol, respectively, at the end of synthesis and radiochemical purities greater than 99%. In U87MG tumor xenograft PET studies, the three tracers experienced higher specific uptake at the tumor site. However, because of significant differences in metabolism and clearance, [68Ga]Ga-DOTA-FAPI-04 experienced high uptake in the kidney, whereas 11C-RJ1101 and 11C-RJ1102 showed high uptake in the liver and intestine. Biodistribution studies revealed significant hepatobiliary excretion of 11C-RJ1101 and 11C-RJ1102. 11C-RJ1102 showed higher specific tumor uptake in U87MG xenografts (1.71 ± 0.08% injected dose per Gram of tissue [ID/g]) than 11C-RJ1101 (1.34 ± 0.10%ID/g) and [68Ga]Ga-DOTA-FAPI-04 (1.29 ± 0.04%ID/g) after 30 min p. i. In orthotopic glioma models, the uptake values were 0.07 ± 0.03% ([68Ga]Ga-DOTA-FAPI-04) and 0.16 ± 0.03% (11C-RJ1102), respectively. Conclusion: 11C-RJ1101 and 11C-RJ1102 are interesting candidates for translation to the clinic, taking advantage of the shorter half-life and physical imaging properties of C-11.
Structural modification and antibacterial property studies of natural chalcone sanjuanolide
Authors: Zhai Jiadai , Li Shucheng , Fu Lin , Li Chuang , Sun Bingxia , Sang Feng , Liu Hongliang 
Published: August 2022

Clinical infections arise from multidrug-resistant bacteria and pose a serious threat to human and global public health. Moreover, due to very few antibiotics being discovered, there is an urgent need to develop new antibacterial agents to combat antimicrobial resistance challenges. In this study, a series of new chalcone derivatives bearing a 3′-hydroxyisoprenyl moiety were prepared to employ Claisen–Schmidt condensation as a key step by combinatorial chemistry, and overall yields of these novel derivatives are in the range of 28–68% in the two-step reaction. Sanjuanolide and the synthesized derivatives have been investigated for their expected antibacterial activities against Gram-positive bacteria (Staphylococcus aureus CMCC 26003) and Gram-negative bacteria (Escherichia coli CMCC 44102). Among these compounds, only 4c (MIC = 12.5 μg/ml) and 4d (MIC = 25 μg/ml) exhibited antibacterial activity comparable to sanjuanolide (MIC = 12.5 μg/ml, against S. aureus CMCC 26003), and the results of subsequent in vivo experiments on sanjuanolide suggest that sanjuanolide exhibits bacteriostatic and bactericidal effects by altering the cellular structure, disrupting the integrity of cell membranes, and reducing the outer membrane potential.
Forecasting of monthly precipitation based on ensemble empirical mode decomposition and Bayesian model averaging
Authors: Luo Shangxue , Zhang Meiling , Nie Yamei , Jia Xiaonan , Cao Ruihong , Zhu Meiting , Li Xiaojuan 
Published: August 2022

Precipitation prediction is crucial for water resources management and agricultural production. We deployed a hybrid model based on ensemble empirical mode decomposition (EEMD) and Bayesian model averaging (BMA), called EEMD-BMA, for monthly precipitation series data at Kunming station from January 1951 to December 2020. Firstly, the monthly precipitation data series was decomposed into multiple Intrinsic Mode Functions (IMFs) and a residue with EEMD. Next, autoregressive integrated moving average (ARIMA), support vector regression (SVR) and long short-term memory (LSTM) models are used to predict components respectively. The prediction results of EEMD-ARIMA, EEMD-SVR and EEMD-LSTM are obtained by summing the prediction results of each component. Finally, BMA is used to combine the prediction results of the EEMD-ARIMA, EEMA-SVR and EEMD-LSTM models, whose weights are calculated by birth-death Markov Chain Monte Carlo algorithm. The results show that the proposed EEMD-BMA model provides more accurate precipitation predictions than the individual models; the RMSE is 17.2811 mm, the MAE is 12.6999 mm and the R2 is 0.9573. Moreover, the coverage probability (CP) and mean width (MW) of the 90% confidence interval for the predicted values of the EEMD-BMA model are 0.9375 and 60.315 mm, respectively. Therefore, the proposed EEMD-BMA model has good application prospects and can provide a basis for decision makers to develop measures against potential disasters.