bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of preoperative venography in predicting the difficulty of a transvenous lead extraction procedure
Authors: Aboelhassan Mohamed , Bontempi Luca , Cerini Manuel , Salghetti Francesca , Arabia Gianmarco , Giacopelli Daniele , Fouad Doaa A. , Abdelmegid Mohamed Aboel‐kassem F. , Ahmed Tarek A.N. , Dell'Aquila Andrea , Curnis Antonio 
Published: March 2022

AbstractIntroductionWe hypothesized that an accurate assessment of preoperative venography could be useful in predicting transvenous lead extraction (TLE) difficulty.Methods and ResultsA dedicated preoperative venogram was performed in consecutive patients with cardiac implantable electronic device who underwent TLE. The level of stenosis was classified as without significant stenosis, moderate, severe, and occlusion. The presence of extensive lead‐venous wall adherence (≥50 mm) was also assessed. A total of 105 patients (median age: 71 years; 72% male) with a median of 2 (1–2) leads to extract were enrolled. Preoperative venography showed moderate to severe stenosis in 31 (30%), complete occlusion in 15 (14%), and extensive lead‐venous wall adherence in 50 (48%) patients. Complete TLE success was achieved in 103 (98%) patients. A total of 55 (52%) were advanced extractions as they required a powered mechanical and/or laser sheath. They were more prevalent in the group with extensive lead‐venous wall adherence (72% vs. 34%, p < .001), while no differences were found between patients with and without venous occlusion. In multivariate analysis, the presence of adherence was a predictor of advanced extraction (odds ratio: 2.89 [1.14–7.32], p = .025). The fluoroscopy time was also significantly longer (14.0 [8.2–18.7] vs. 5.1 [2.1–10.0] min, p < .001). The rate of complications did not differ based on the presence of venous lesions.ConclusionAlthough procedural success and complication rates were similar, patients with extensive lead‐venous wall adherence required a longer fluoroscopy time and were three times more likely to need advanced extraction tools. Conversely, the presence of total venous occlusion had no impact on the procedure complexity.
A new Congrid eel, Rhynchoconger smithi sp. nov. (Anguilliformes: Congridae), from the Bay of Bengal, India
Authors: Mohapatra Anil , Ho Hsuan‐Ching , Acharya Smrutirekha , Ray Dipanjan , Mishra Subhrendu Sekhar 
Published: March 2022

AbstractA new Conger eel species is described based on four specimens collected from Petuaghat fishing harbour, West Bengal, India. The combination of morphological characters and molecular data are discordant with the seven congeners currently recognized. Rhynchoconger smithi sp. nov. can be distinguished by having head smaller than trunk; pre‐anal length more than three times in total length; a small eye, diameter 2.0–2.2 in snout length; rictus ending at a vertical through posterior margin of pupil; ethmovomerine teeth patch small, with 58–74 blunt teeth arranged in seven to eight irregular rows; vomerine teeth patch small, with 18–28 granular teeth arranged in four to six irregular rows, distinctly separated by narrow spaces from the ethmovomerine and maxillary teeth; three supraorbital pores and one supra‐temporal pore; and 159+ to 164 total vertebrae. Moreover, R. smithi differs significantly from four congeners, R. nitens, R. flavus, R. ectenurus and R. gracilior, with Kimura two‐parameter (K2P) distances 14.6%–20.3%.
Long‐term morbidity and mortality in patients with Cushing's syndrome
Authors: Braun Leah T. , Vogel Frederick , Reincke Martin 
Published: March 2022

AbstractIncreased multisystem morbidity and mortality in patients with Cushing's syndrome comprise clinical problems and challenges, both at the time of diagnosis and in remission. Relevant comorbidities and clinical problems include hypertension, diabetes, overweight, myopathy and a high risk for acute complications such as infections and venous thrombembolism. Although there are therapy recommendations for most of these comorbidities, there is a lack of large, prospective studies to confirm and optimise them. Mortality is especially high during active disease and within the first year after diagnosis, as a result of cardiovascular events, infections and suicide. All in all, interdisciplinary therapy management is important for reducing morbidity and mortality over the long‐term.
Randomized experiment on the effect of incentives and mailing strategy on response rates in a mail survey of dentists
Authors: McKernan Susan C. , Reynolds Julie C. , McInroy Brooke , Damiano Peter C. 
Published: March 2022

AbstractObjectivesResponse rates for mail surveys of dentists and other health care providers have declined appreciably over the past several decades. The objective of this study was to update evidence about the impact use of incentives and different mail strategies on response rates in a mail survey of dentists.MethodsWe randomized private practice dentists in Iowa (N = 1267) into six study groups to test the effects of incentives and mail strategy on response rate. Survey incentives included either a $2 bill or a customized pen/stylus; a control group with no incentive was included. Mail strategies included bulk mail or first‐class stamps.ResultsThe overall survey response rate was 43%. A $2 bill incentive was associated with significantly higher likelihood of returning a survey compared to the control group with no incentive (48% response rate vs. 40%, respectively). A non‐monetary incentive was not significantly associated with likelihood of response. Use of first‐class stamps compared to bulk mail did not significantly affect response rate.ConclusionsThis study demonstrated the effectiveness of a $2 incentive to increase response rate in a mail survey of dentists. Given the background trend of declining survey participation rates, researchers should consider use of monetary incentives and explore new strategies to increase participation among dentists and other health care providers.
Preliminary evaluation of a non‐invasive device for monitoring intracranial pressure waveforms in dogs
Authors: Bahr Arias M. V. , Conceição R. T. , Guimarães F. C. , Cardoso G. S. , Rocha N. L. F. C. 
Published: March 2022

ObjectivesThe objective of this study was to compare waveforms obtained with a new device for the non‐invasive monitoring of intracranial pressure (ICP) in dogs with and without neurological disease.Materials and MethodsThis prospective study was conducted on both neurologically normal dogs and dogs with neurological diseases. First, non‐invasive ICP waveforms were recorded in normal dogs using the Braincare® BcMM 2000 monitor while the dogs were under general anaesthesia induced for procedures unrelated to this study. The dogs were positioned in lateral recumbency, and the sensor was placed over the skin of the parietal region. Secondly, non‐invasive ICP waveforms were monitored in dogs with brain and spinal disease until waveforms with characteristic peaks were acquired. All the recorded signals were amplified, filtered and digitalized, by the device, and then transferred to a computer for analysis.ResultsNormal pulse waveforms indicating normal brain complacency were observed in eight neurologically normal dogs. In six dogs with brain disease, abnormal pulse waveforms were observed suggesting increased ICP and decreased brain complacency. Four dogs with spinal disease undergoing myelography, had normal waveforms before contrast medium injection and abnormal pulse waveforms during contrast medium injection, indicating a potential increase in ICP.Clinical SignificanceBased on these preliminary observations, this method was capable of detecting abnormal pulse waveforms that suggested increased ICP.
“Passing Down Pollution”: (Inter)generational Toxicology and (Epi)genetic Environmental Health
Authors: Lamoreaux Janelle 
Published: March 2022

AbstractConcern about the harmful health effects of industrial pollution is increasingly taking on an intergenerational dimension. In environmental health sciences such as toxicology, this has resulted in emphasizing the influence of toxic chemicals, substances, and situations across generations. Toxic relationalities are now being explored through research on gene–environment interaction, including toxicogenomics and epigenetic research through animal experiments and birth cohort studies. Based on fieldwork conducted among reproductive and developmental toxicologists working in Nanjing, China, this article shows how toxicological research both expresses and produces renewed anxieties about “passing down pollution.” These toxicological accounts of intergenerational harm problematically work through overly simplistic renderings of reproduction and biological relatedness. But they also have the potential to catalyze creative understandings of toxic relationalities and responsibilities at a moment when making kin is increasingly seen as key to securing livable futures. [toxicology, environment, epigenetics, kinship, China]
Toward Intergenerational Ethnography: Kinship, Cohorts, and Environments in and Beyond the Biosocial Sciences
Authors: Gibbon Sahra , Lamoreaux Janelle 
Published: March 2022

AbstractSituated alongside and drawing from emerging inquiry, debate, and reflection about making and unmaking kin at a moment of critical reflection on racial, social, and reproductive inequities and changing environments, this special edition considers how anthropology can ethnographically examine and engage with intergenerational dynamics as they influence different scales and spheres of life. It brings together medical anthropologists and science and technology scholars conducting research in Bangladesh, China, the United Kingdom, South Africa, and the United States as they reflect on the un/making of kin in settings of expert knowledge production and dissemination, including practices of seed collecting, epigenetic science, birth cohort studies, social policy generation, and clinical trials. Contributors to this special issue consider how intergenerational relations and modes of transmission take form in and through biosocial research—both as an object of study and a method of analysis. [intergenerational, environmental change, kinship, biosocial]
Distinct early life stage gene expression effects of hybridization among European and North American farmed and wild Atlantic salmon populations
Authors: Islam Shahinur S. , Xue Xi , Caballero‐Solares Albert , Bradbury Ian R. , Rise Matthew L. , Fleming Ian A. 
Published: March 2022

AbstractDue to multigeneration domestication selection, farmed and wild Atlantic salmon diverge genetically, which raises concerns about potential genetic interactions among escaped farmed and wild populations and disruption of local adaptation through introgression. When farmed strains of distant geographic origin are used, it is unknown whether the genetic consequences posed by escaped farmed fish will be greater than if more locally derived strains are used. Quantifying gene transcript expression differences among divergent farmed, wild and F1 hybrids under controlled conditions is one of the ways to explore the consequences of hybridization. We compared the transcriptomes of fry at the end of yolk sac absorption of a European (EO) farmed (“StofnFiskur”, Norwegian strain), a North American (NA) farmed (Saint John River, NB strain), a Newfoundland (NF) wild population with EO ancestry, and related F1 hybrids using 44 K microarrays. Our findings indicate that the wild population showed greater transcriptome differences from the EO farmed strain than that of the NA farmed strain. We also found the largest differences in global gene expression between the two farmed strains. We detected the fewest differentially expressed transcripts between F1 hybrids and domesticated/wild maternal strains. We also found that the differentially expressed genes between cross types over‐represented GO terms associated with metabolism, development, growth, immune response, and redox homeostasis processes. These findings suggest that the interbreeding of escaped EO/NA farmed and NF wild population would alter gene transcription, and the consequences of hybridization would be greater from escaped EO farmed than NA farmed salmon, resulting in potential effects on the wild populations.
A MITE variation‐associated heat‐inducible isoform of a heat‐shock factor confers heat tolerance through regulation of JASMONATE ZIM‐DOMAIN genes in rice
Authors: Wu Nai , Yao Yilong , Xiang Denghao , Du Hao , Geng Zedong , Yang Wanneng , Li Xianghua , Xie Tingting , Dong Faming , Xiong Lizhong 
Published: March 2022

Summary

High temperatures cause huge yield losses in rice. Heat‐shock factors (Hsfs) are key transcription factors which regulate the expression of heat stress‐responsive genes, but natural variation in and functional characterization of Hsfs have seldom been reported.

A significant heat response locus was detected via a genome‐wide association study (GWAS) using green leaf area as an indicative trait. A miniature inverted‐repeat transposable element (MITE) in the promoter of a candidate gene, HTG3 (heat‐tolerance gene on chromosome 3), was found to be significantly associated with heat‐induced expression of HTG3 and heat tolerance (HT). The MITE‐absent variant has been selected in heat‐prone rice‐growing regions.

HTG3a is an alternatively spliced isoform encoding a functional Hsf, and experiments using overexpression and knockout rice lines showed that HTG3a positively regulates HT at both vegetative and reproductive stages. The HTG3‐regulated genes were enriched for heat shock proteins and jasmonic acid signaling. Two heat‐responsive JASMONATE ZIM‐DOMAIN (JAZ) genes were confirmed to be directly upregulated by HTG3a, and one of them, OsJAZ9, positively regulates HT.

We conclude that HTG3 plays an important role in HT through the regulation of JAZs and other heat‐responsive genes. The MITE‐absent allele may be valuable for HT breeding in rice.
Cold urticaria in a pediatric cohort: Clinical characteristics, management, and natural history
Authors: Prosty Connor , Gabrielli Sofianne , Mule Pasquale , Le Gallee Madison , Miles Laura May , Le Michelle , Zhang Xun , Ensina Luis F. , Netchiporouk Elena , Ben‐Shoshan Moshe 
Published: March 2022

AbstractBackgroundCold urticaria (coldU) is associated with substantial morbidity and risk of fatality. Data on coldU in children are sparse. We aimed to evaluate the clinical characteristics, management, risk of associated anaphylaxis, and resolution rate of coldU in a pediatric cohort. Additionally, we sought to compare these metrics to children with chronic spontaneous urticaria (CSU).MethodsWe prospectively enrolled children with coldU from 2013–2021 in a cohort study at the Montreal Children's Hospital and an affiliated allergy clinic. Data for comparison with participants with solely CSU were extracted from a previous study. Data on demographics, comorbidities, severity of presentation, management, and laboratory values were collected at study entry. Patients were contacted yearly to assess for resolution.ResultsFifty‐two children with cold urticaria were recruited, 51.9% were female and the median age of symptom onset was 9.5 years. Most patients were managed with second‐generation H1‐antihistamines (sgAHs). Well‐controlled disease on sgAHs was negatively associated with concomitant CSU (adjusted odds ratio (aOR) = 0.69 [95%CI: 0.53, 0.92]). Elevated eosinophils were associated with cold‐induced anaphylaxis (coldA; aOR = 1.38 [95%CI: 1.04, 1.83]), which occurred in 17.3% of patients. The resolution rate of coldU was 4.8 per 100 patient‐years, which was lower than that of CSU (adjusted hazard ratio = 0.43 [95%CI: 0.21, 0.89], p < 10−2).ConclusionPediatric coldU bears a substantial risk of anaphylaxis and a low‐resolution rate. Absolute eosinophil count and co‐existing CSU may be useful predictive factors.
A rare presentation of herpes simplex virus encephalitis occurring in a pediatric patient on dupilumab for atopic dermatitis
Authors: Rao Megana , Grove Daniel , Haggstrom Anita 
Published: March 2022

AbstractA 4‐year‐old female with a history of atopic dermatitis developed herpes simplex virus (HSV) encephalitis while being treated with dupilumab and concomitant topical steroids. There was no prior history of HSV infections or immunodeficiency. To our knowledge, this is the first case of HSV encephalitis in a patient receiving dupilumab.
Jürgen Habermas and the public intellectual in modern democratic life
Authors: Verovšek Peter J. 
Published: March 2022

AbstractThis paper provides an overview of Jürgen Habermas's writings as a public intellectual and relates this work to recent debates about the proper relationship of theory to practice. In addition to being one of the most influential continental philosophers of the postwar era, Habermas is also the leading public intellectual of the Federal Republic of Germany and increasingly of the European Union as well. Unfortunately, his political writings have not received the attention they deserve. As a result, he is often misconstrued as an ideal theorist who is both ignorant of and apathetic toward ‘real’ politics. By showing how his philosophy relates to his political engagement, I present Habermas as a model for how the philosopher can apply theoretical insights to political developments in an indirect, mediated manner that focuses on debates within the democratic public sphere. This approach has distinct advantages when compared to active participation in the policymaking process and the direct application of philosophy to political practice, both of which threaten the principle of democratic equality in the public sphere.
Rotation‐Invariant Self‐Similarity Descriptor for Multi‐Temporal Remote Sensing Image Registration
Authors: Mohammadi Nazila , Sedaghat Amin , Jodeiri Rad Mahya 
Published: March 2022

Abstract
In this paper, a novel approach for the registration of multi‐sensor remote sensing images with substantial time differences is proposed. The proposed method consists of four main steps. First, robust image features are extracted using the well‐known UR‐SURF (uniform robust‐speeded up robust features) algorithm. Second, the feature descriptors are generated using a novel method based on self‐similarity measure, named RISS (rotation invariant self‐similarity). The RISS descriptor is an inherent rotation‐invariant descriptor based on the gradient orientation histogram of correlation values and is very resistant against illumination differences. Third, the outlier rejection process is performed based on a simple improvement of graph transform matching, named LWGTM (localized weighted graph transformation matching). Finally, the estimation of the transformation model and the rectification process are done using TPS (thin‐plate spline) model and the bilinear interpolation method. Five multi‐sensor remote sensing image pairs with relatively long years of time difference are used for evaluation. The results indicate the capability of the proposed method for reliable remote sensing image registration. The average recall, precision, the number of extracted matched points and the average registration accuracy of the proposed method are about 31.6, 39.5, 4940, and 1.8 pixels, respectively.
Physiological integration between Bermudagrass ramets improves overall salt resistance under heterogeneous salt stress
Authors: Yin Yan‐Ling , Xu Ya‐Nan , Li Xiao‐Ning , Fan Shu‐Gao , Wang Guang‐Yang , Fu Jin‐Min 
Published: March 2022

AbstractConnected ramets of colonal plants often suffer from different environmental conditions such as light, nutrient, and stress. Colonal Bermudagrass (Cynodon dactylon [L.] Pers.) can form interconnected ramets and this connection facilitates the tolerance to abiotic stress, which is a kind of physiological integration. However, how bermudagrass responds to heterogeneously distributed salt stress needs to be further elucidated. Here, we demonstrated that severance of stolons aggravated the damage of salt‐stressed ramets, displaying higher relative electrolytic leakage (EL), lower content of chlorophyll, higher accumulation of Na+, and serious oxidative damages. This finding implied the positive effects of the physiological integration of bermudagrass on salt tolerance. The unstressed ramets connected with the stressed one were mildly injured, implying the supporting and sacrifice function of the unstressed ramets. Physiological integration did not mediate the translocation of Na+ among ramets, but induced a higher expression of salt overly sensitive (SOS) genes in the stressed ramets, consequently reducing the accumulation of Na+ in leaves and roots. In addition, physiological integration upregulated the genes expression and enzymes activity of catalase (CAT) and peroxidase (POD) in both stressed and unstressed ramets. This granted a stronger antioxidant ability of the whole clonal plants under salt stress. Enhanced Na+ transfer and increased reactive oxygen species (ROS) scavenging are mechanisms that likely contribute to the physiological integration leading to the salt tolerance of bermudagrass.
Sugars and the speed of life—Metabolic signals that determine plant growth, development and death
Authors: Wingler Astrid , Henriques Rossana 
Published: March 2022

AbstractPlant growth and development depend on the availability of carbohydrates synthesised in photosynthesis (source activity) and utilisation of these carbohydrates for growth (sink activity). External conditions, such as temperature, nutrient availability and stress, can affect source as well as sink activity. Optimal utilisation of resources is under circadian clock control. This molecular timekeeper ensures that growth responses are adjusted to different photoperiod and temperature settings by modulating starch accumulation and degradation accordingly. For example, during the night, starch degradation is required to provide sugars for growth. Under favourable growth conditions, high sugar availability stimulates growth and development, resulting in an overall accelerated life cycle of annual plants. Key signalling components include trehalose‐6‐phosphate (Tre6P), which reflects sucrose availability and stimulates growth and branching when the conditions are favourable. Under sink limitation, Tre6P does, however, inhibit night‐time starch degradation. Tre6P interacts with Sucrose‐non‐fermenting1‐Related Kinase1 (SnRK1), a protein kinase that inhibits growth under starvation and stress conditions and delays development (including flowering and senescence). Tre6P inhibits SnRK1 activity, but SnRK1 increases the Tre6P to sucrose ratio under favourable conditions. Alongside Tre6P, Target of Rapamycin (TOR) stimulates processes such as protein synthesis and growth when sugar availability is high. In annual plants, an accelerated life cycle results in early leaf and plant senescence, thus shortening the lifespan. While the availability of carbohydrates in the form of sucrose and other sugars also plays an important role in seasonal life cycle events (phenology) of perennial plants, the sugar signalling pathways in perennials are less well understood.