bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Silico Characterization and Expression Analysis of GIGANTEA Genes in Potato
Authors: Karsai-Rektenwald Flóra , Odgerel Khongorzul , Jose Jeny , Bánfalvi Zsófia 
Published: March 2022

AbstractGIGANTEA (GI) genes are ubiquitous in the plant kingdom and are involved in diverse processes from flowering during stress responses to tuberization; the latter occurs in potato (Solanum tuberosum L.). GI genes have a diurnal cycle of expression; however, no details on the regulation of GI gene expression in potato have been reported thus far. The aim of our work was the analysis of the GI promoter sequence and studying GI expression in different organs and under abiotic stress conditions in potato. Two GI genes homologous to Arabidopsis GI located on chromosomes 4 and 12 (StGI.04 and StGI.12) were identified in the genome-sequenced potato S. phureja. The GI promoter regions of the commercial potato cultivar ‘Désirée’ were cloned and found to be almost identical to the S. phureja GI promoter sequence. More than ten TF families binding to the GI promoters were predicted. EVENING ELEMENT and ABSCISIC ACID RESPONSE ELEMENT LIKE elements related to circadian regulation and a binding site for POTATO HOMEOBOX 20 presumably involved in tuber initiation were detected in both GI promoters. However, the locations of these elements and several other cis-acting regulatory elements as well as the organ-specific expression and responses of the genes to abiotic stresses and abscisic acid were different. Thus, we presume that the function of StGI.04 and StGI.12 are at least partially different. This study lays foundation for further investigation of the roles of GI genes in potato.
Assessment of potassium soil balances and availability in high yielding rice systems
Authors: Linquist Bruce A. , Campbell Johnny C. , Southard Randal J. 
Published: March 2022

AbstractPlant demand for K in rice is comparable to nitrogen. With yields and management practices changing, refining K fertility management and decision-making tools is necessary. Our objectives were to determine (1) how soil K balances affect soil K indices, (2) the best soil test indicator of plant K availability, and (3) the relationships between plant and soil K indices. We assessed soil (plow layer) and flag-leaf samples from 55 commercial rice fields in California. Growers provided historical information on K fertility practices, straw management, and yields to develop a soil K balance. A soil K balance average of − 15 kg K ha−1 yr−1(range: − 72 to 47) suggested an increased likelihood of K infertility; however, K balance was not correlated with soil K indices or flag-leaf K. This, plus the potential for K losses and fixation of surplus K, suggests that attempting to build up soil K may not be an effective strategy. Soil K indices were poorly correlated with plant K, but 1 N NH4OAc-extractable K (Kext) was the best of the K indices tested. Soils that were low in Kext had low clay content, CEC, and K saturation, a high Ca + Mg:K ratio, and showed evidence of K fixation. Soil K varied regionally and may be related to irrigation water and soil parent material. The critical level for Kext (currently 60 mg K kg−1) may need to be revised based on our findings, as there was evidence of K deficiencies above this concentration.
Exploring hospital efficiency within and between Italian regions: new empirical evidence
Authors: Barra Cristian , Lagravinese Raffaele , Zotti Roberto 
Published: March 2022

AbstractThis paper investigates the efficiency of Italian hospitals and how their performances have changed over the years 2007–2016, characterized by the great economic recession and budget constraints. We apply the Benefit of Doubt (BoD) approach to determine a composite index that considers the multi-dimensionality of the hospital outcome to be used as main output in a metafrontier production function based on a stochastic frontier framework. The efficiency score distribution is then used to construct a Theil index in order to compare, over time, the inequality of the estimated efficiency between hospitals, both within and between regions. The main findings show that the primary source of inefficiency comes from managerial inefficiency especially for hospitals located in southern regions. A clear and persistent North-South gap in efficiency performances of hospitals has been found along with an increase in the inequality in terms of efficiency between the areas of the country mostly determined by between region inequality.
Relativizing proportionality to a domain of events
Authors: Touborg Caroline Torpe 
Published: March 2022

AbstractA cause is proportional to its effect when, roughly speaking, it is at the right level of detail. There is a lively debate about whether proportionality is a necessary condition for causation. One of the main arguments against a proportionality constraint on causation is that many ordinary and seemingly perfectly acceptable causal claims cite causes that are not proportional to their effects. In this paper, I suggest that proponents of a proportionality constraint can respond to this objection by developing an idea that is present in Yablo’s early work on proportionality, but which has strangely been ignored by both Yablo and others in the subsequent debate. My suggestion is that proportionality—and, indeed, causation itself—is relative to a domain of events. At the metaphysical level, this means that the causal relation has an extra relatum—namely, a domain of events. At the level of language, it introduces a new way in which causal claims are context-sensitive: what is expressed by a causal claim depends on the contextually relevant domain of events. As I argue, this suggestion allows us to accommodate the truth of ordinary causal claims while extending the explanatory benefits of a proportionality constraint.
SoftPool++: An Encoder–Decoder Network for Point Cloud Completion
Authors: Wang Yida , Tan David Joseph , Navab Nassir , Tombari Federico 
Published: March 2022

AbstractWe propose a novel convolutional operator for the task of point cloud completion. One striking characteristic of our approach is that, conversely to related work it does not require any max-pooling or voxelization operation. Instead, the proposed operator used to learn the point cloud embedding in the encoder extracts permutation-invariant features from the point cloud via a soft-pooling of feature activations, which are able to preserve fine-grained geometric details. These features are then passed on to a decoder architecture. Due to the compression in the encoder, a typical limitation of this type of architectures is that they tend to lose parts of the input shape structure. We propose to overcome this limitation by using skip connections specifically devised for point clouds, where links between corresponding layers in the encoder and the decoder are established. As part of these connections, we introduce a transformation matrix that projects the features from the encoder to the decoder and vice-versa. The quantitative and qualitative results on the task of object completion from partial scans on the ShapeNet dataset show that incorporating our approach achieves state-of-the-art performance in shape completion both at low and high resolutions.
Robust utility maximizing strategies under model uncertainty and their convergence
Authors: Sass Jörn , Westphal Dorothee 
Published: March 2022

AbstractIn this paper we investigate a utility maximization problem with drift uncertainty in a multivariate continuous-time Black–Scholes type financial market which may be incomplete. We impose a constraint on the admissible strategies that prevents a pure bond investment and we include uncertainty by means of ellipsoidal uncertainty sets for the drift. Our main results consist firstly in finding an explicit representation of the optimal strategy and the worst-case parameter, secondly in proving a minimax theorem that connects our robust utility maximization problem with the corresponding dual problem. Thirdly, we show that, as the degree of model uncertainty increases, the optimal strategy converges to a generalized uniform diversification strategy.
What Clinical Trials Are Needed for Treatment of Leiomyosarcoma?
Authors: Kasper Bernd , D’Ambrosio Lorenzo , Davis Elizabeth J. , Ingham Matthew , Broto Javier Martin , Trent Jonathan C. , van Houdt Winan J. , Van Tine Brian A. 
Published: March 2022

Opinion statementLeiomyosarcoma is one of the most common subtypes of soft tissue sarcomas accounting for approximately 20% of sarcomas. As leiomyosarcoma patients frequently develop metastatic disease, effective systemic therapies are needed to improve clinical outcomes. The overall activity of the currently available conventional systemic therapies and the prognosis of patients with advanced and/or metastatic disease are poor. As such, the treatment of this patient population remains challenging. As a result, there is a clear unmet medical need, and designing and performing meaningful clinical studies are of utmost importance to improve the prognosis of this patient group. Therefore, the aim of this review is to briefly summarize state-of-the-art treatments for leiomyosarcoma patients and to describe trial characteristics needed for informative clinical studies.
Astronomers’ representations of the earth and day / night cycle: Implications for children’s acquisition of scientific concepts
Authors: Nobes Gavin , Frède Valérie , Panagiotaki Georgia 
Published: March 2022

AbstractPrevious researchers (e.g., Vosniadou and Brewer, Cognitive Psychology 24:535–585, 1992) have claimed that children have naïve, but coherent, mental models of the earth, such as the flat earth and the hollow sphere. Recent studies have challenged this view, focusing on the original researchers’ methods of testing (drawing and open questions) and coding. In this study we tested the construct validity of these methods by asking expert astronomers to complete the same test originally used with 5-year-olds. Many astronomers gave responses that, if given by young children, would have been considered non-scientific and as evidence of naïve mental models. Many gave two or more seemingly contradictory answers to the same questions and, even when only their ‘most scientific’ responses were considered, fewer than 50% of these expert scientists were classified as having coherent scientific mental models. Comparison with children’s responses to a rephrased and disambiguated task indicated that even 6–7-year-olds gave more scientific answers. The astronomers’ comments revealed the main reasons why the original task lacks validity: they found many questions confusing and ambiguous. This may well explain many children’s responses, too. Since the task incorrectly indicates that experts in the field have fundamental misconceptions, it is likely also to have led to substantial underestimates of children’s scientific understanding.
18F-FDG PET/CT as predictive and prognostic factor in esophageal cancer treated with combined modality treatment
Authors: Krengli Marco , Ferrara Eleonora , Guaschino Riccardo , Puta Erinda , Turri Lucia , Luciani Ilaria , Sacchetti Gian Mauro , Franco Pierfrancesco , Brambilla Marco 
Published: March 2022

Abstract
Purpose
[18F] fluorodeoxyglucose positron emission tomography/computed tomography ([18F] FDG-PET/CT) is used for diagnosis, staging, response assessment and prognosis prediction in different tumors, but its role in esophageal cancer is still debated. The aim of this study was to evaluate the role of semiquantitative baseline PET parameters as possible prognostic and predictive factors in a series of esophageal carcinomas treated with combined modalities.

Methods
43 patients with esophageal carcinoma were treated with chemoradiotherapy (CRT) followed by surgery in 20 cases and underwent pre-treatment 18F-FDG-PET/CT. Semiquantitative PET parameters were evaluated including Standardized Uptake Value (SUVmax e SUVmean), Metabolic Tumor Volume (MTV) and Total Lesion Glycolysis (TLG) with isocontour of 41 and 50%. Further variables analyzed were gender, primary tumor site, histological type, use of surgery, achievement of a radical resection and the type of chemotherapy regimen. The correlation of all variables with treatment response, loco-regional control (LR), Overall survival (OS) and Disease-Free Survival (DFS) was evaluated.

Results
SUVmax, SUVmean50 and SUVmean41 were significantly higher in node-positive cases and in squamous cell carcinomas. With respect to prognostic factors, MTV was found to be correlated with OS: patients with MTV41 < 11.32 cm3 and MTV50 < 8.07 cm3 (both p values = 0.04) showed better 3-year OS rates (33 vs. 20%). Further factors predicting a better prognosis were the use of surgery and radical resection (R0) (both p values < 0.01).

Conclusions
Pre-treatment MTV values were significant prognostic factors for OS, together with the use of surgery and R0 resection in esophageal cancers treated with multimodal therapies.
Traits and Distorted Symptom Presentation: a Scoping Review
Authors: van Helvoort Daniël , Merckelbach Harald , van Nieuwenhuizen Chijs , Otgaar Henry 
Published: March 2022

AbstractAre personality traits related to symptom overreporting and/or symptom underreporting? With this question in mind, we evaluated studies from 1979 to 2020 (k = 55), in which personality traits were linked to scores on stand-alone validity tests, including symptom validity tests (SVTs) and measures of socially desirable responding (SDR) and/or supernormality. As to symptom overreporting (k = 14), associations with depression, alexithymia, apathy, dissociation, and fantasy proneness varied widely from weak to strong (rs .27 to .79). For underreporting (k = 41), inconsistent links (rs − .43 to .63) were found with narcissism, whereas alexithymia and dissociation were often associated with lower SDR tendencies, although effect sizes were small. Taken together, the extant literature mainly consists of cross-sectional studies on single traits and contexts, mostly offering weak correlations that do not necessarily reflect causation. What this field lacks is an overarching theory relating traits to symptom reporting. Longitudinal studies involving a broad range of traits, samples, and incentives would be informative. Until such studies have been done, traits are best viewed as modest concomitants of symptom distortion.
Underwater LED-based Lagrangian particle tracking velocimetry
Authors: Viola Ignazio Maria , Nila Alex , Davey Thomas , Gabl Roman 
Published: March 2022

Abstract
A new white-light volumetric flow measurement technique is presented that can be used in large-scale facilities. The technique enables large volumes to be measured with high temporal and spatial resolution and without the need for a class-4 laser. This LED-based Lagrangian particle tracking velocimetry is demonstrated by measuring the tip vortex formation and the near wake of a 1.2 m diameter tidal turbine in a 25 m diameter, 2 m deep tank. Seven streamwise-distributed volumes of interest are combined, each 334 mm long, 244 mm wide and 140 mm deep, reaching up to one diameter downstream of the turbine. The system does not require re-calibration when moved. By assuming a periodic flow field, a phase-averaged flow field was reconstructed with a temporal resolution of 3.9 ms and a spatial resolution of 5.4 mm. The large volume and high time and spatial resolution could enable key research questions to be addressed on high-Reynolds-number flows and could provide valuable benchmark data for numerical model development and code validation.

Graphical abstract
Polysaccharides from Tamarindus indica L. as natural kinetic hydrates inhibitor at high subcooling environment
Authors: Effendi Adam Daniel , Jiaqi Low , Sia Chee Wee , Jasamai Mazuin , Sulaimon Aliyu Adebayo 
Published: March 2022

AbstractIn an offshore system, hydrocarbon fluids are produced at deeper depths in the oceans, and extended pipelines delivering fluids over long distances are common. Subsequently, these practices increase the tendency of unprocessed water-containing hydrocarbon fluid to be exposed to lower temperatures and higher pressures conditions where hydrate formation is favourable. One of the solutions to resolve this problem is by introducing hydrate inhibitors preferably low dosage hydrate inhibitors (LDHIs). The more versatile LDHIs; Kinetic Hydrate Inhibitors (KHIs) could further be optimised in cost and its biodegradation properties. The current study used an ionic, neutral, hydrophilic, mucoadhesive and highly branchedTamarindus indica L. polysaccharide(TSP).TSP as a new natural kinetic hydrate inhibitor due to its high methoxyl content. In this study, the polysaccharides were extracted using water-based extraction method which resulted in 61.3% yield. The performance of TSP in delaying the clathrate hydrates formation was evaluated based on the induction time recorded from the thermogram generated by a high pressure micro-differential scanning calorimeter device (HP-μDSC) at pressure of 5 MPa with subcooling degree of 17.3 °C. Three TSP concentrations (0.10 wt%, 0.25 wt%, and 0.50 wt%) were tested to determine the optimal concentration used to increase the delay time at the prescribed conditions while comparing it to a condition when there is no addition of TSP. The outcomes shows that TSP is able to delay hydrates formation at high degree of subcooling. The TSP works well at low concentration at high degree of subcooling while remain relatively economical and biodegradable.
Out of the Woods Yet? The Continuing Impact of National Standards on New Zealand Music Education
Authors: Browne Jade 
Published: March 2022

AbstractSeveral years have passed since the removal of National Standards, however the current provision and enactment of music education in New Zealand remains unknown. Using a case study, this article seeks to illustrate the current practice of music education at one high decile primary school. This study finds that despite the removal National Standards, reading, writing and mathematics have continued to be prioritised, dominating classroom timetables, initial teacher education and the allocation of resources and professional development. With limited opportunities for music-making in the classroom, I argue that practice has stagnated and without targeted policies, music will continue to be marginalised within the curriculum.
Mass estimation method for intelligent vehicles based on fusion of machine learning and vehicle dynamic model
Authors: Yu Zhuoping , Hou Xinchen , Leng Bo , Huang Yuyao 
Published: March 2022

AbstractVehicle mass is an important parameter for motion control of intelligent vehicles, but is hard to directly measure using normal sensors. Therefore, accurate estimation of vehicle mass becomes crucial. In this paper, a vehicle mass estimation method based on fusion of machine learning and vehicle dynamic model is introduced. In machine learning method, a feedforward neural network (FFNN) is used to learn the relationship between vehicle mass and other state parameters, namely longitudinal speed and acceleration, driving or braking torque, and wheel angular speed. In dynamics-based method, recursive least square (RLS) with forgetting factor based on vehicle dynamic model is used to estimate the vehicle mass. According to the reliability of each method under different conditions, these two methods are fused using fuzzy logic. Simulation tests under New European Driving Cycle (NEDC) condition are carried out. The simulation results show that the estimation accuracy of the fusion method is around 97%, and that the fusion method performs better stability and robustness compared with each single method.
Low-Intensity Electrostimulation Enhances Neuroregeneration and Improves Erectile Function in a Rat Model of Cavernous Nerve Injury
Authors: Sturny Mikael , Karakus Serkan , Fraga-Silva Rodrigo , Stergiopulos Nikolaos , Burnett Arthur L. 
Published: March 2022

ABSTRACTBackgroundNeurogenic erectile dysfunction (ED) following radical prostatectomy (RP) is a frequent complication often leading to erectile tissue remodeling and permanent ED. Low-intensity electrostimulation (LIES) has been shown to enhance peripheral nerve regeneration, however, its application on cavernous nerves (CN) has never been investigated.AimsTo investigate whether LIES enhances CN regeneration, improves erectile function (EF) recovery, and prevents corpora cavernosal remodeling after CN injury, which is a principal factor for ED following RP.MethodsAdult male Sprague-Dawley rats were divided into Sham, Bilateral Cavernous Nerve Injury (BCNI), and BCNI + LIES (1V, 0.1ms, 12Hz, 1h/day). After 7days, EF was assessed (ICP measurement). Penes and CN were collected for molecular analyses of TGF-β1, Il-6, CRP, eNOS, ERK and AKT protein levels in corpus cavernosum (CC), and immunohistological analysis of DHE, total collagen and α-SMA in CC and S-100, Tub-III, DAPI, TUNEL, and nNOS in CN.OutcomesEffects of LIES on EF, erectile tissue remodeling and CN structure.ResultsEF was decreased (P &lt; .05) 7 days after BCNI and increased (P &lt; .05) by LIES. Intracavernosal reactive oxygen species (DHE) was increased (P &lt; .05) after BCNI and normalized by LIES. Protein expressions of TGF-β1, IL-6, and CRP were increased in the penis (P &lt; .05) after BCNI and normalized by LIES. The α-SMA and/or total collagen ratio was decreased (P &lt; .05) after BCNI in the penis and normalized by LIES. Protein expression ratio of p-ERK/ERK and p-AKT/AKT did not change after BCNI but increased (P &lt; .05) in LIES group. Myelination and number of nNOS positive cells in the CN were decreased (P &lt; .05) after BCNI and normalized by LIES. The number of apoptotic nerve cells within the dorsal penile nerve was increased (P &lt; .05) after BCNI and decreased (P &lt; .05) by LIES compared to the BCNI group. There were no differences in eNOS expression in the penis between study groups.Clinical TranslationLIES may offer a potential new tool for penile rehabilitation and ED management following RP, potentially enhancing EF recovery and minimizing the side effects of this surgery.Strengths & LimitationsThis study provides evidence of the protective effect of LIES on EF and tissue remodeling following CN injury; nevertheless, this study has been conducted on animals and the translation to humans remains to be demonstrated. Further research to identify the underlying mechanisms of action is required.ConclusionThis study demonstrates that LIES of the CN after CN injury protects CN structure, enhances EF recovery, and prevents corpora cavernosal remodeling.
TheQalandarKing: Early Development of theQalandariyyātand Saljuq Conceptions of Kingship in Amir Moʿezzi's Panegyric for Sharafshāh Jaʿfari
Authors: Miller Matthew Thomas 
Published: March 2022

AbstractHistorical treatments of the “rogue lyrics” (qalandariyyāt) of medieval Persian poetry typically identify their origin in the Sufi poetry of Bābā Tāher, Abu Saʿid, and Sanāʾi and portray them as a poetic instantiation of the intellectual and antinomian critiques of the formalistic modes of piety practiced in the increasingly powerful institutionalized Sufi orders. However, theqalandaripanegyrics of the Saljuq court poets Borhāni and Amir Moʿezzi—arguably the earliest datable examples of this poetry—analyzed in this article complicate this narrative. They utilize the heterotopic poetics of theqalandariyyātnot to subvert or critique, but rather to augment the sociopolitical authority of the ruler of Qazvin, constructing a new and distinctly Saljuq model of Islamic kingship, aQalandarKing.