bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mass to voltage ratio index predicts mortality following TAVI
Authors: Porat Alon , Gordon Max , Perlman Gidon , Planer David , Danenberg Haim , Alcalai Ronny , Leibowitz David 
Published: February 2022

AbstractTranscatheter aortic valve implantation (TAVI) is commonly performed in elderly patients with aortic stenosis. Better methods of risk stratification are needed in this population with high morbidity. There is a relatively high incidence of cardiac amyloidosis in this population and high LV mass index (LVMI) to QRS voltage may help identify patients with worse prognosis following TAVI. This retrospective study enrolled consecutive patients who underwent TAVI in our institution between the years 2008–2019. Mass voltage ratio index (MVRi) was calculated as the ratio of LV mass index on echocardiogram to voltage using the Sokolow‐Lyon criteria on 12 lead ECG performed within 3 months before the intervention. Two hundred and fifty‐one patients (mean age 80.8 years, 49% men) were enrolled. One hundred and sixty‐eight (67%) patients were alive at 3 years follow up. MVRi was a statistically significant predictor of 3 year mortality (p < 0.005). Patients were divided categorically into tertiles based on MVRi score; the “high” group had significantly higher 3‐year mortality (p < 0.001). In the multivariate model only Euroscore (p < 0.009) and MVRi (p < 0.011; OR: 2.32; CI: 1.15–4.964) were statistically significant predictors of mortality. The “high” group had a significantly lower survival rate after 3 years follow up on Kaplan–Meier analysis (p < 0.001). Our findings suggest that MVRi is a strong, independent predictor of increased post‐TAVI mortality. This may be a simple clinical tool to assist in the assessment of patients prior to before TAVI.
Elevation of creatine kinase in acute pancreatitis: A case report
Authors: Sheibani Mehdi , Hajibaratali Bahareh , Yeganegi Houra 
Published: February 2022

AbstractCreatine kinase (CK/CK‐MB) testing is an essential laboratory test approaching a patient with chest or epigastric pain. We report a 38‐year‐old man with acute pancreatitis and elevated CK/CK‐MB level without myocardial involvement. Acute pancreatitis may be considered as a false‐positive cause of CK/CK‐MB test in patients presenting with chest pain.
Surgical management of an odontogenic cutaneous sinus tract misdiagnosed for 4 years
Authors: Latifa Hammouda , Dorsaf Touil , Amira Kikly , Karim Jlassi , Nabiha Douki 
Published: February 2022

AbstractA cutaneous sinus tract of dental origin may easily be misdiagnosed and incorrectly treated. This paper reported a case of a 20‐year‐old male patient referred for a productive cutaneous sinus tract misdiagnosed by medical doctors for more than 4 years. The clinical and radiographic examinations confirmed the odontogenic origin related to a mandibular first right molar presenting an infected radicular cyst. Surgical treatment was performed leading to a significant healing of the sinus tract.
Improved explosion resistance of low cement refractory castables using drying agents
Authors: Peng Hong , Myhre Bjørn 
Published: February 2022

AbstractLow cement castables (LCCs) containing different types of drying agents (polymer fibers and EMSIL‐DRY™) have been studied both in laboratory‐ and industrial‐scale. Our study shows that the type of drying agent has a profound impact on the flow/workability of the fresh castables and that EMSIL‐DRY™ ensures the best workability. The thermal behavior of 300 mm cubes (approximately 80 kg) was studied using a unique macro‐thermo‐balance (macro‐TGA). Compared to the polymer fibers, EMSIL‐DRY™ reduces the temperature level for maximum dewatering rate and will effectively help prevent explosions during heat‐up. The LCC with EMSIL‐DRY™ showed excellent explosion resistance, as demonstrated by the production of a perfect 400 kg block that was fired to 850°C at a rate of 75°C/h.
Filtrationstechnik als Schlüssel für Sicherheit und Qualität
Authors: Schaub Marius 
Published: February 2022

AbstractFiltration und Separation gehören zu den wesentlichen Verfahren in der Prozessindustrie. Aktuelle Entwicklungen im Bereich der Trenntechnik vermittelt die Filtech: Als wichtigste Plattform für die Filtration und Separation aller Arten von Medien bietet die Veranstaltung Besuchern eine Kombination aus Messe und Kongress. Im März 2022 findet die Filtech nach Corona‐bedingter Pause wieder statt.
“Einstufung und Partikelgröße von Titandioxid von Pulvermischungen mit Titandioxid auf die Betroffenheit durch die Einstufung von Titandioxidpulvern”
Authors: Beck Giuliana , Thüsing Anne 
Published: February 2022

AbstractSeit den 1. Oktober 2021 ist sie verbindlich umzusetzen: die Einstufung von Titandioxid‐Pulvern in der CLP‐Verordnung als Krebsverdachtsstoff (Karzinogen, Kategorie 2). Der Einstufungseintrag ist komplex und stellt sowohl Hersteller als auch Verarbeiter von Titandioxid vor neue Herausforderungen.
PROTOCOL: Psychological and psychosocial determinants of COVID Health Related Behaviours (COHeRe): A suite of systematic reviews and an evidence and gap map
Authors: Hanratty Jennifer , Keenan Ciara , O'Connor Sean , Miller Sarah , Bradley Declan , Dempster Martin 
Published: February 2022

AbstractThis is the protocol for a Campbell systematic review. The objectives are as follows: we intend to identify and synthesise the existing evidence (published and unpublished) on malleable psychological and psychosocial factors that determine uptake and adherence to behaviours that can reduce the risk of infection or transmission of COVID‐19.
Magnetically Manipulable Ionic Liquid Crystals Incorporating Neutral Radicals
Authors: Uchida Yoshiaki , Sakaguchi Tatsunori , Oki Shigeaki , Shimono Satoshi , Park Jayeong , Sugiyama Masahito , Sato Shuichi , Zaytseva Elena , Mazhukin Dmitrii G. , Tamura Rui 
Published: February 2022

AbstractInvited for this month's cover are the collaborating groups of Dr. Yoshiaki Uchida from Osaka University, Japan, Prof. Rui Tamura and Prof. Masahito Sugiyama from Kyoto University, Japan and Dr. Dmitrii G. Mazhukin from Novosibirsk State University, Russia. The cover picture depicts a contrast between localized spins and conductive ions in the newly‐synthesized ionic liquid crystalline (ILC) nitroxide radicals. The ILC droplet of the new compounds is magnetically manipulable. More information can be found in the Full Paper by Yoshiaki Uchida, Rui Tamura, and co‐workers.
Minding my brain: Fourteen neuroscience‐based principles to enhance psychotherapy responsiveness
Authors: Faustino Bruno 
Published: February 2022

AbstractIntersections between psychotherapy and neurosciences are at its dawn. The quest to understand the neural underpinnings of psychological processes has led several generations of scientists to explore neural correlates between mind, brain and behaviour. Neuroscience methods and research have given psychology new perspectives and insights about the structure and function of complex neural pathways that underlie human functioning (cognition, emotion, motivation, somatic reactions and interpersonal behaviour). By translating neuroscientific findings into psychotherapeutic principles of change, it is possible to promote responsiveness towards brain dysfunction that underlies patients' psychological malfunctioning. In psychotherapy, responsiveness is a core aspect of the therapeutic change process, especially to adapt psychological interventions to patients' motivational stages and preferences, coping styles, neurobehavioural modes and emotional needs. Within a transtheoretical and translational approach, contemporary neuroscientific findings are revised, discussed and used to attempt to build on 14 theoretical brain‐based principles that may be applied to psychotherapy. Translating these empirical findings into practical principles, clinical strategies and tasks is expected to enhance psychotherapy responsiveness grounded on a science‐based knowledge of brain functioning.
The common‐sense model and mental illness outcomes: A meta‐analysis
Authors: Cannon Margeaux , Credé Marcus , Kimber Justin M. , Brunkow Alexandria , Nelson Rebecca , McAndrew Lisa M. 
Published: February 2022

AbstractPsychotherapists can improve their patients' outcomes during and after therapy by improving patients' self‐management. Patients who do not effectively manage their mental illness generally have worse outcomes. Leventhal's Common‐Sense Model of Self‐Regulation theorizes that patients' perceptions of their illness (illness representations) guide their self‐management, influencing health outcomes. The present study quantified the relations between illness representations, self‐management and outcomes for mental illnesses. We conducted a meta‐analysis and included articles if they reported (1) on adults with mental illnesses and (2) the correlation between mental illness representations and mental illness outcomes. Twenty‐five articles were included which represented 28 independent samples. The pattern of correlations among illness representations (identity, consequences, timeline, control, coherence and emotional representations), self‐management strategies (attendance, engagement and adherence to treatment) and mental illness outcomes (symptom severity and quality of life) was consistent with analyses from previous studies of mental and physical illnesses. The results found threat‐related illness representations mostly had a large relationship with worse mental illness outcomes and self‐management. Protective illness representations had a small‐to‐large relationship with better mental illness outcomes and self‐management. The results suggest patients' perceptions of their mental illness may be a critical indicator of their mental illness outcomes, including symptom severity and quality of life. This theory‐driven meta‐analysis supports calls for the inclusion of illness representations in psychotherapy for mental illness.
RiPCA: An Assay for the Detection of RNA‐Protein Interactions in Live Cells
Authors: Rosenblum Sydney L. , Garner Amanda L. 
Published: February 2022

AbstractIncreasing interest in studying and modulating the interactions between RNAs and their RNA‐binding proteins has indicated the need for enabling technologies. Existing means of detecting RNA‐protein interactions (RPIs) are often limited to biochemical or post‐lysis methods or cell‐based methods that require the addition of an RNA‐based affinity tag, such as the MS2 hairpin, precluding them from use in detecting small or highly processed RNAs. Taking advantage of bioorthogonal chemistry‐ and split‐luciferase‐based technologies, we developed an assay for the detection of RPIs in live cells. This article details the protocol and design considerations for RiPCA, or RNA interaction with Protein‐mediated Complementation Assay. © 2022 Wiley Periodicals LLC.
Expression of netrin and its receptors uncoordinated‐5 and frazzled in arthropods and onychophorans suggests conserved and diverged functions in neuronal pathfinding and synaptogenesis
Authors: Janssen Ralf , Budd Graham E. 
Published: February 2022

AbstractBackgroundDevelopment of the nervous system and the correct connection of nerve cells require coordinated axonal pathfinding through an extracellular matrix. Outgrowing axons exhibit directional growth toward or away from external guidance cues such as Netrin. Guidance cues can be detected by growth cones that are located at the end of growing axons through membrane‐bound receptors such as Uncoordianted‐5 and Frazzled. Binding of Netrin causes reformation of the cytoskeleton and growth of the axon toward (or away from) the source of Netrin production.ResultsHere, we investigate the embryonic mRNA expression patterns of netrin genes and their potential receptors, uncoordinated‐5 and frazzled in arthropod species that cover all main branches of Arthropoda, that is, Pancrustacea, Myriapoda, and Chelicerata. We also studied the expression patterns in a closely related outgroup species, the onychophoran Euperipatoides kanangrensis, and provide data on expression profiles of these genes in larval tissues of the fly Drosophila melanogaster including the brain and the imaginal disks.ConclusionOur data reveal conserved and diverged aspects of neuronal guidance in Drosophila with respect to the other investigated species and suggest a conserved function in nervous system patterning of the developing appendages.
Monitoring partially marked populations using camera and telemetry data
Authors: Margenau Lydia L. S. , Cherry Michael J. , Miller Karl V. , Garrison Elina P. , Chandler Richard B. 
Published: February 2022

AbstractLong‐term monitoring is an important component of effective wildlife conservation. However, many methods for estimating density are too costly or difficult to implement over large spatial and temporal extents. Recently developed spatial mark–resight (SMR) models are increasingly being applied as a cost‐effective method to estimate density when data include detections of both marked and unmarked individuals. We developed a generalized SMR model that can accommodate long‐term camera data and auxiliary telemetry data for improved spatiotemporal inference in monitoring efforts. The model can be applied in two stages, with detection parameters estimated in the first stage using telemetry data and camera detections of instrumented individuals. Density is estimated in the second stage using camera data, with all individuals treated as unmarked. Serial correlation in detection and density parameters is accounted for using time‐series models. The two‐stage approach reduces computational demands and facilitates the application to large data sets from long‐term monitoring initiatives. We applied the model to 3 years (2015–2017) of white‐tailed deer (Odocoileus virginianus) data collected in three study areas of the Big Cypress Basin, Florida, USA. In total, 59 females marked with ear tags and fitted with GPS‐telemetry collars were detected along with unmarked females on 180 remote cameras. Most of the temporal variation in density was driven by seasonal fluctuations, but one study area exhibited a slight population decline during the monitoring period. Modern technologies such as camera traps provide novel possibilities for long‐term monitoring, but the resulting massive data sets, which are subject to unique sources of observation error, have posed analytical challenges. The two‐stage spatial mark–resight framework provides a solution with lower computational demands than joint SMR models, allowing for easier implementation in practice. In addition, after detection parameters have been estimated, the model may be used to estimate density even if no synchronous auxiliary information on marked individuals is available, which is often the case in long‐term monitoring.
Serum autotaxin as a novel prognostic marker in patients with non‐ischaemic dilated cardiomyopathy
Authors: Araki Takashi , Okumura Takahiro , Hiraiwa Hiroaki , Mizutani Takashi , Kimura Yuki , Kazama Shingo , Shibata Naoki , Oishi Hideo , Kuwayama Tasuku , Kondo Toru , Morimoto Ryota , Takefuji Mikito , Murohara Toyoaki 
Published: February 2022

AbstractAimsAutotaxin (ATX) promotes myocardial inflammation, fibrosis, and the subsequent cardiac remodelling through lysophosphatidic acid production. However, the prognostic impact of serum ATX in non‐ischaemic dilated cardiomyopathy (NIDCM) has not been clarified. We investigated the prognostic impact of serum ATX in patients with NIDCM.Methods and resultsWe enrolled 104 patients with NIDCM (49.8 ± 13.4 years, 76 men). We divided the patients into two groups using different cutoffs of median serum ATX levels for men and women: high‐ATX group and low‐ATX group. Cardiac events were defined as a composite of cardiac death and heart failure resulting in hospitalization. Median ATX level was 203.5 ng/mL for men and 257.0 ng/mL for women. Brain natriuretic peptide levels [224.0 (59.6–689.5) pg/mL vs. 96.5 (40.8–191.5) pg/mL, P = 0.010] were higher in the high‐ATX group than low‐ATX group, whereas high‐sensitivity C‐reactive protein and collagen volume fraction levels in endomyocardial biopsy samples were not significantly different between the two groups. Kaplan–Meier survival analysis revealed that the event‐free survival rate was significantly lower in the high‐ATX group than low‐ATX group (log‐rank; P = 0.007). Cox proportional hazard analysis revealed that high‐ATX was an independent determinant of composite cardiac events. In both sexes, serum ATX levels did not correlate with high‐sensitivity C‐reactive protein levels and collagen volume fraction but had a weak correlation with brain natriuretic peptide levels (men; spearman's rank: 0.274, P = 0.017, women; spearman's rank: 0.378, P = 0.048).ConclusionHigh serum ATX levels can be associated with increasing adverse clinical outcomes in patients with NIDCM. These results indicate serum ATX may be a novel biomarker or therapeutic target in NIDCM.
Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T‐follicular helper cells and germinal center B cells
Authors: Venkatadri Rajkumar , Sabapathy Vikram , Dogan Murat , Mohammad Saleh , Harvey Scott E. , Simpson Sean R. , Grayson Jason M. , Yan Nan , Perrino Fred W. , Sharma Rahul 
Published: February 2022

AbstractThe Three Prime Repair EXonuclease I (TREX1) is critical for degrading post‐apoptosis DNA. Mice expressing catalytically inactive TREX1 (TREX1 D18N) develop lupus‐like autoimmunity due to chronic sensing of undegraded TREX1 DNA substrates, production of the inflammatory cytokines, and the inappropriate activation of innate and adaptive immunity. This study aimed to investigate Thelper (Th) dysregulation in the TREX1 D18N model system as a potential mechanism for lupus‐like autoimmunity. Comparison of immune cells in secondary lymphoid organs, spleen and peripheral lymph nodes (LNs) between TREX1 D18N mice and the TREX1 null mice revealed that the TREX1 D18N mice exhibit a Th1 bias. Additionally, the T‐follicular helper cells (Tfh) and the germinal celter (GC) B cells were also elevated in the TREX1 D18N mice. Targeting Bcl6, a lineage‐defining transcription factor for Tfh and GC B cells, with a commercially available Bcl6 inhibitor, FX1, attenuated Tfh, GC, and Th1 responses, and rescued TREX1 D18N mice from autoimmunity. The study presents Tfh and GC B‐cell responses as potential targets in autoimmunity and that Bcl6 inhibitors may offer therapeutic approach in TREX1‐associated or other lupus‐like diseases.
On the use of gender categories and emotion categories in threat‐based person impressions
Authors: Rees Heather R. , Sherman Jeffrey W. , Klauer Karl Christoph , Todd Andrew R. 
Published: February 2022

AbstractPeople often form impressions of others in contexts where both relatively static demographic cues (e.g., age, race, gender) and situationally flexible, dynamic cues (e.g., emotion expressions) are available. We examined whether and how attending to gender (male, female) versus emotion expression (neutral, smiling) affects threat‐based person impressions. In three experiments, we heightened the salience of either gender categories or emotion categories in a sequential priming task. Category salience consistently moderated the use of both categories in threat impressions. The effect of gender (emotion) categories was stronger when attention was directed to gender (emotion) than when attention was directed to emotion (gender); however, category salience did not eliminate the use of either category. Implications for models of person construal and bias in person impressions are discussed.
Women who challenge or defend the status quo: Ingroup identities as predictors of progressive and reactionary collective action
Authors: Mikołajczak Gosia , Becker Julia C. , Iyer Aarti 
Published: February 2022

AbstractCollective action (CA) research looking at gender has focused predominantly on feminist activism, overlooking activism of women who reinforce gender inequalities and traditional gender roles (such as women supporting men's rights or anti‐abortion protesters). Our research addresses this oversight, demonstrating the key role of identity content in predicting CA in support of progressive and reactionary social change among women. Using two large online samples of women from the US (Study 1: N = 1825) and the UK (Study 2: N = 992), we show that identification with ‘women’ is either weakly associated or unrelated to progressive and reactionary CA and is thus too broad to differentiate between support for CA with opposing goals. In contrast, subgroup identities matter: feminist identification is associated with support for progressive CA, while identification with traditional women is associated with support for reactionary CA. We discuss the implications of our findings for research on CA and gender inequalities.
Zirconium Oxide Nanoparticles Modified Carbon Paste Electrode for Simultaneous Voltammetric Determination of Mebendazole and Levamisole Hydrochloride in Pharmaceutical Formulation and Human Plasma
Authors: El‐Eryan Rasha Th. , Toubar Safaa S. , Ashour Azza A. , Elshahed Mona S. 
Published: February 2022

AbstractA new, simple and highly sensitive electrochemical method based on zirconium oxide nanoparticles modified carbon paste electrode (2 % ZrO2/CPE) was used for simultaneous determination of anthelmintics drugs Mebendazole (MB) and Levamisole HCl (LV) in drug substance, dosage form and human plasma. Differential pulse (DPV) and square wave (SWV) voltammetric analysis were applied in Britton Robinson buffer (pH 6; 0.04 M) after optimization of different analytical parameters. The studied drugs were measured simultaneously at very low concentration of analytes resulting in two well‐separated peaks. The detection limits were found to be 0.01 and 0.62 μM for MB and LV, respectively, using DPV and 0.01 and 0.42 μM for MB and LV, respectively using SWV.
Hierarchical three dimensional polyaniline/N‐doped graphene nanocomposite hydrogel for energy storage applications
Authors: Sardana Silki , Aggarwal Kanika , Siwach Priya , Gaba Latisha , Maan A. S. , Singh Kuldeep , Ohlan Anil 
Published: February 2022

AbstractWith the rapid development of portable, lightweight, and flexible electronics, the requirement for advanced energy storage systems has arisen that need to be flexible and cost‐effective with higher power/energy densities. In this context, a two‐step approach has been adopted to develop a binder‐free and flexible supercapacitor electrode on carbon cloth based on hierarchical three dimensional (3D) conducting polymer hydrogels. Firstly, nitrogen‐doped graphene (NGN) was synthesized using urea as a reducing as well as a doping agent. Subsequently, polyaniline (PAni) hydrogel has been grown on NGN nanosheets via insitu oxidative polymerization in the vicinity of carbon cloth and further utilized as an electrode for electrochemical measurements. Here, phytic acid was used as a gelatinizer and as a dopant resulting in the formation of a cross‐linked hydrogel structure. The direct deposition of PAni/NGN nanocomposite on carbon cloth strengthens the juncture involving the carbon cloth and electrode material, resulting in enhanced electron transmission. The 3D hydrogel architecture ascertains robust contact between electrolyte and electrode for an efficient charge storage system. For a two‐electrode symmetric arrangement, at 1 A/g, PAni/NGN nanocomposite hydrogel displayed a maximum specific capacitance of 808.7 F/g due to the pseudocapacitive reaction on/near the accessible surface area, as well as an outstanding rate capability and cyclic performance due to electric double layer capacitance (EDLC). The supercapacitor cell delivered maximum specific power and specific energy value of 0.44 kW/kg and 13.63 Wh/kg, respectively. Thus, the composite hydrogel has the benefit of being able to be utilized directly as binder‐free supercapacitor electrodes, leading to viable choice for high‐performance and cost‐effective energy storage devices.