bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatocyte Nuclear Factor 1α Controls the Expression of Terminal Complement Genes
Authors: Pontoglio Marco , Pausa Mario , Doyen Antonia , Viollet Benoit , Yaniv Moshe , Tedesco Francesco 
Published: July 2002

The terminal components of the complement system contribute to host defense by forming the multiprotein membrane attack complex (MAC) which is responsible for cell lysis and several noncytotoxic effects. Most of the complement proteins are synthesized in the liver, but the mechanisms controlling their tissue-specific expression have not been elucidated. In this study we show that mice lacking the hepatic transcription factor hepatocyte nuclear factor 1α (HNF1α) fail to transcribe C5 and C8A complement genes. In addition, mRNAs encoding for several other terminal complement components or subunits are expressed at lower levels, including C8β, C8γ, and C9. We next used a reconstitution assay involving human sera with selective complement deficiencies to assess mouse complement activity. Sera from HNF1α-deficient mice showed negligible hemolytic activity of both C5 and C8α-γ subunits. The activity of C8β was severely affected despite only a 50% reduction in C8β mRNA levels in the liver. This is reminiscent of C8α-γ–deficient patients who accumulate extremely low levels of the C8β subunit.
Our results demonstrate that HNF1α plays a key role in the expression of C5 and C8A genes, two terminal complement component genes that are essential for the assembly of MAC as a result of complement activation.
CRAWview: for viewing splicing variation, gene families, and polymorphism in clusters of ESTs and full-length sequences.
Authors: Chou A , Burke J 
Published: July 2002

Abstract
MOTIVATION: DNA sequence clustering has become a valuable method in support of gene discovery and gene expression analysis. Our interest lies in leveraging the sequence diversity within clusters of expressed sequence tags (ESTs) to model gene structure for the study of gene variants that arise from, among other things, alternative mRNA splicing, polymorphism, and divergence after gene duplication, fusion, and translocation events. In previous work, CRAW was developed to discover gene variants from assembled clusters of ESTs. Most importantly, novel gene features (the differing units between gene variants, for example alternative exons, polymorphisms, transposable elements, etc.) that are specialized to tissue, disease, population, or developmental states can be identified when these tools collate DNA source information with gene variant discrimination. While the goal is complete automation of novel feature and gene variant detection, current methods are far from perfect and hence the development of effective tools for visualization and exploratory data analysis are of paramount importance in the process of sifting through candidate genes and validating targets. RESULTS: We present CRAWview, a Java based visualization extension to CRAW. Features that vary between gene forms are displayed using an automatically generated color coded index. The reporting format of CRAWview gives a brief, high level summary report to display overlap and divergence within clusters of sequences as well as the ability to 'drill down' and see detailed information concerning regions of interest. Additionally, the alignment viewing and editing capabilities of CRAWview make it possible to interactively correct frame-shifts and otherwise edit cluster assemblies. We have implemented CRAWview as a Java application across windows NT/95 and UNIX platforms. AVAILABILITY: A beta version of CRAWview will be freely available to academic users from Pangea Systems (http://www.pangeasystems.com). Contact :
Editorial
Authors: Mascarenhas Marcello Ávila 
Published: August 2022

Em meio a esses dois anos de pandemia do Covid-19, a Revista Ciência em Movimento com temática em Reabilitação e Saúde teve uma demanda enorme de produções, o que possibilitou na nova edição compartilhar com a comunidade científica artigos com muita qualidade.A edição atual teve o foco no cuidado em saúde como forma de reabilitação e inclusão, segundo Heidegger (1996 – adaptado) permite-nos refletir sobre o modo ser dos humanos como concepção/realização, havendo um tempo determinado pelo contexto do próprio ator, do ambiente que vive e os olhares novos que a pandemia nospossibilitou, o que permitiu que as obras publicadas transcendessem a academia e contribuíssem para as suas condições de saúde e vida dos seres humanos.E assim, os artigos publicados nesse número transitam em uma contextualização, sobre o processo saúde - doença – cuidado, utilizando estratégias terapêuticas e inclusivas, onde a humanização do sujeito torna–se objeto de esforços no sentido da compreensão, formulação de novos olhares/modelo/estratégias e formas de intervenção.
Technology integration in learning management: A post-pandemic phenomenological study in elementary schools
Authors: Ilyas Muhammad , Herwin Herwin , Ma'rufi Ma'rufi , Lidyasari Aprilia Tina , Da Costa Augusto 
Published: August 2022

The post-pandemic period in the education sector is marked by government policies to carry out face-to-face education processes in schools. This situation has the potential to show various changes in learning management in elementary schools, especially with the integration of technology. This study aims to analyse the integration of technology in learning management in elementary schools during the post-pandemic period. This study uses a qualitative approach to the type of phenomenology. The research subjects were elementary school teachers who had been selected through a convenience technique based on the availability of subjects in the field. Data were collected through interviews and documentation. Data were analysed using qualitative analysis through data condensation, data presentation, verification and drawing conclusions. The study’s findings show that the integration of technology in learning management tends to decrease during the post-pandemic period. Some habits of using technology in learning during the pandemic are no longer applied during the pandemic. However, some uses of technology are still maintained, such as the use of the WhatsApp group application in the delivery of learning information and the use of mobile-based assessment applications in learning assessment.

Keywords: Technology integration, learning management, post-pandemic.
Strategies to Build Students' Moderate Attitude Through the Cultivation of Ahlusunnah Values Waljamaah Annahdliyah (Descriptive study at SMP Plus Maarif NU Ciamis and SMP Plus Maarif NU Pangandaran)
Authors: Maftuh  Salam  , Ulfiah  , Didin Wahidin  , Ujang Nurjaman  
Published: August 2022

The emergence of intolerant radical Islamic groups, who are easy to heresy, disbelieve in other groups, can even lead to hostility and conflict against other groups who disagree, is a trend of intolerance and radicalism in Indonesia that tends to increase. Kecenderungan ini dipengaruhi beberapa factor terutama kontestasi politik, ceramah atau pidato bermuatan ujaran kebencian di media social (medsos) dan media lainnya. Tujuan penelitian ini adalah untuk memperoleh gambaran tentang strategi membangun sikap moderat peserta didik melalui penanaman nilai-nilai ahlusunnah waljamaah annahdliyah di sekolah menengah pertama. This study uses a qualitative approach with descriptive methods and data collection techniques through interviews, observations, and document studies. The results showed that the strategy to build a moderate religious attitude of students was carried out through the cultivation of Aswaja An Nahdliyah values based on school culture. and Islamic boarding schools that adhere to the teachings of Islam Ahlussunnah Waljamaah An Nahdliyah through the values of Tawasuth (moderate), 'Itidal (straight/fair), Tasamuh (tolerance) and Tawazun (balance) through strategic steps a) providing knowledge with a model (rationalization) through Aswaja learning, b). Habituation, and c) Extracurricular Pagar Nusa, d) Good interaction and communication between teachers and students and e) Charismatic approach, (Suritauladan) with the cohesiveness of all ranks in the two schools.
"التعارض والترجيح" عند الأصوليين وأثرهما على الأحكام الفقهية
Authors: MAHMOOD SAJID , Ullah Dr. Irfan , Ullah Dr. Hayat 
Published: August 2022

There is no contradiction between the shar'i arguments in reality, but in the eyes of the mujtahid, so it is an apparent contradiction, not a real one. Due to this apparent contradiction, the two contradictory arguments require that in a case for which the mujtahid is seeking a ruling, different and contradictory rulings apply at the same time. The condition for this apparent contradiction is that the two arguments are equal in strength, such as two verses of the Qur'an or two Ahadith. In this case, a mujtahid seeks out the history of both texts. Now here, it raises the question of how can we resolve the conflict? So, if the mujtahid learns of their history, he immediately decides that the text that arrives later cancels the text that arrives first. But if one does not know the history of the two contradictory texts, then the mujtahid should prefer one text over the other and adopt the five major methods prescribed by the usooliyeen (scholars of Usool e Fiqh), which are: Abrogation, then “weighting,” then “combining and reconciling,” then “falling both proofs.” This article contains these five methods in detail.
Association of Maternal Antipsychotic Prescription During Pregnancy With Standardized Test Scores of Schoolchildren in Denmark
Authors: Liu Xiaoqin , Trabjerg Betina Bitsch , Munk-Olsen Trine , Christensen Jakob , Dreier Julie Werenberg 
Published: August 2022

ImportanceAn increasing number of individuals fill antipsychotic prescriptions during pregnancy, and concerns have been raised about prenatal antipsychotic exposure on neurodevelopmental outcomes.ObjectiveTo examine whether maternal prescription fill for antipsychotics during pregnancy was associated with performance in standardized tests among schoolchildren.Design, Setting, and ParticipantsThis register-based cohort study included 667 517 children born in Denmark from January 1, 1997, to December 31, 2009, and who were attending public primary and lower secondary school. All children had completed at least 1 language (Danish) or mathematics test as part of the Danish National School Test Program between 2010 and 2018. Data were analyzed from November 1, 2021, to March 31, 2022.ExposuresAntipsychotic prescriptions filled by pregnant individuals were obtained from the Danish National Prescription Register.Main Outcomes and MeasuresDifferences in standardized test scores (range, 1-100; higher scores indicate better test results) in language and mathematics between children of mothers with and without antipsychotic prescription fills during pregnancy were estimated using linear regression models. Seven sensitivity analyses, including a sibling-controlled analysis, were performed.ResultsOf the 667 517 children included (51.2% males), 1442 (0.2%) children were born to mothers filling an antipsychotic prescription during pregnancy. The mean (SD) age of children at the time of testing spanned from 8.9 (0.4) years in grade 2 to 14.9 (0.4) years in grade 8. Maternal prescription fill for antipsychotics was not associated with performance in language (crude mean test score: 50.0 [95% CI, 49.1-50.9] for the exposed children vs 55.4 [95% CI, 55.4-55.5] for the unexposed children; adjusted difference, 0.5 [95% CI, −0.8 to 1.7]) or in mathematics (crude mean test score: 48.1 [95% CI, 47.0-49.3] for the exposed children vs 56.1 [95% CI, 56.1-56.2] for the unexposed children; adjusted difference, 0.4 [95% CI, −1.0 to 1.8]). There was no evidence that results were modified by the timing of filling prescriptions, classes (first-generation and second-generation) of antipsychotics, or the most commonly prescribed antipsychotic monotherapies, including chlorprotixene, flupentixol, olanzapine, zuclopenthixol, quetiapine, perphenazine, and methotrimeprazine. The results remained robust across sensitivity analyses, including sibling-controlled analyses, negative control exposures analyses, and probabilistic bias analyses.Conclusions and RelevanceIn this register-based cohort study, maternal prescription fill for antipsychotics during pregnancy did not appear to be associated with standardized test scores in the offspring. The findings provide further reassuring data on offspring neurodevelopmental outcomes associated with antipsychotic treatment during pregnancy.
Adult-Onset Genetic Central Nervous System Disorders Masquerading as Acquired Neuroinflammatory Disorders
Authors: Ayrignac Xavier , Carra-Dallière Clarisse , Marelli Cecilia , Taïeb Guillaume , Labauge Pierre 
Published: August 2022

ImportanceAdult-onset genetic disorders may present with clinical and magnetic resonance imaging (MRI) features suggestive of acquired inflammatory diseases. An ever-growing number of potentially treatable adult-onset genetic neuroinflammatory disorders have been described in the past few years that need to be rapidly identified.ObservationsAdult-onset acquired neuroinflammatory disorders encompass a large group of central nervous system (CNS) diseases with varying presentation, MRI characteristics, and course, among which the most common is multiple sclerosis. Despite recent progress, including the discovery of specific autoantibodies, a significant number of adult-onset neuroinflammatory disorders with progressive or relapsing course still remain without a definite diagnosis. In addition, some patients with genetic disorders such as leukodystrophies, hemophagocytic lymphohistiocytosis, or genetic vasculopathies can mimic acquired neuroinflammatory disorders. These genetic disorders, initially described in pediatric populations, are increasingly detected in adulthood thanks to recent progress in molecular genetics and the larger availability of high-throughput sequencing technologies.Conclusions and RelevanceGenetic adult-onset neuroinflammatory diseases are at the border between primary CNS inflammatory diseases and systemic disorders with multiorgan involvement and predominantly neurologic manifestations. Neurologists must be aware of the main clues and red flags so they can confirm a diagnosis early, when some of these genetic disorders can be successfully treated.
Temporal trends in Black‐White disparities in cancer surgery and cancer‐specific survival in the United States between 2007 and 2015
Authors: Zhong Peijie , Yang Bo , Pan Feng , Hu Fang 
Published: August 2022

AbstractBackgroundThe American Society of Clinical Oncology (ASCO) has strived to address racial/ethnic disparities in cancer care since 2009. Surgery plays a pivotal role in cancer care; however, it is unclear whether and how racial/ethnic disparities in cancer surgery have changed over time.MethodsThis cohort study included 1,113,256 White and Black cancer patients across 9 years (2007–2015) using patient data extracted from the Surveillance, Epidemiology, and End Results (SEER)‐18 registries. Patient data were included from 2007 to adjust insurance status and by 2015 to obtain at least a 3‐year survival follow‐up (until 2018). The primary outcome was a surgical intervention. The secondary outcomes were the use of (neo)adjuvant chemotherapy and cancer‐specific survival (CSS). Adjusted associations of the race (Black/White) with the outcomes were measured in each cancer type and year.ResultsThe gap between surgery rates for Black and White patients narrowed overall, from an adjusted odds ratio (aOR) of 0.621 (0.592–0.652) in 2007 to 0.734 (0.702–0.768) in 2015. However, the racial gap persisted in the surgery rates for lung, breast, prostate, esophageal, and ovarian cancers. In surgically treated patients with lymph node metastasis, Black patients with colorectal cancer (CRC) were less likely to receive (neo)adjuvant chemotherapy than White patients. Black patients undergoing surgery were more likely to have a worse CSS rate than White patients undergoing surgery. In breast cancer patients, the overall trend was narrow, but continuously present, with an adjusted hazard ratio (aHR) of 1.224 (1.278–1.173) in 2007 and 1.042 (1.132–0.96) in 2015.ConclusionsOverall, progress has been made toward narrowing the Black‐White gap in cancer surgical opportunity and survival. Future efforts should be directed toward those specific cancers for which the Black‐White gap continues. Additionally, it is worth addressing the Black‐White gap regarding the use of (neo)adjuvant chemotherapy for CRC treatment.
Survival benefits of primary tumor surgery for synchronous brain metastases: A SEER‐based population study with propensity‐matched comparative analysis
Authors: Zhang Chengkai , Zhang Yuan , Li Deling , Jia Wang 
Published: August 2022

AbstractBackgroundEvidence about the prognostic value of primary tumor surgery (PTS) in patients with brain metastatic malignancies is ambiguous and controversial. This study assessed the survival benefits of primary tumor surgery in patients with brain metastases (BMs).MethodsAdults patients with BMs that originated from lung, breast, kidney, skin, colon, and liver diagnosed between 2010 and 2018 were derived from the Surveillance, Epidemiology, and End Results database (SEER). Propensity score matching (PSM) was used to balance the bias between patients with or without PTS. Then the prognostic value of PTS was estimated by Kaplan–Meier analysis and Cox proportional hazard regression models.ResultsA total of 32,760 patients with BMs secondary to non‐small cell lung cancer (NSCLC), small cell lung cancer (SCLC), breast cancer, renal cancer, melanoma, colorectal cancer, and liver cancer were identified from the database. After PSM at 1:1 ratio, PTS appeared to significantly prolong cause‐specific survival (CSS) time for patients with BMs secondary to NSCLC, breast cancer, renal cancer, and colorectal cancer (hazard ratio [HR] = 0.60 [0.53–0.68], 0.56 [0.43–0.73], 0.47 [0.37–0.60], and 0.59 [0.37–0.95], respectively, all p < 0.05). Patients with earlier T and N classifications, no extracranial metastasis, and cancer‐specific subtypes (adenocarcinoma in NSCLC, hormone receptor‐negative breast cancer) may derive more survival benefits from PTS when suffering from BMs.ConclusionThis population‐based study supported PTS could provide survival benefits for patients with BMs secondary to NSCLC, breast cancer, renal cancer, and colorectal cancer. More emphasis should be put on PTS of selected patients with BMs.
Molecular Modelling and Atomistic Insights into the Binding Mechanism of MmpL3 Mtb
Authors: Kwofie Samuel K. , Hanson George , Sasu Henrietta , Enninful Kweku S. , Mensah Francis A. , Nortey Richmond T. , Yeboah Omane P. , Agoni Clement , Wilson Michael D. 
Published: August 2022

AbstractMycobacterial membrane proteins Large (MmpLs), which belong to the resistance, nodulation, and division (RND) protein superfamily, play critical roles in transporting polymers, lipids, and immunomodulators. MmpLs have become one of the important therapeutic drug targets to emerge in recent times. In this study, two homology modelling techniques, Modeller and SWISS‐MODEL, were used in modelling the three‐dimensional protein structure of the MmpL3 of Mycobacterium tuberculosis using that of M. smegmatis as template. MmpL3 inhibitors, namely BM212, NITD304, SPIRO, and NITD349, in addition to the co‐crystalized ligands AU1235, ICA38, SQ109 and rimonabant, were screened against the modelled structure and the Mmpl3 of M. smegmatis using molecular docking techniques. Protein‐ligand interactions were analysed using molecular dynamics simulations and Molecular Mechanics Poisson‐Boltzmann surface area computations. Novel residues Gln32, Leu165, Ile414, and Phe35 were identified as critical for binding to M. tuberculosis MmpL3, and conformational dynamics upon inhibitor binding were discussed.
X‐linked hypophosphatemic rickets: Case report of late diagnosis and bone pain improvement with targeted treatment
Authors: Bermeo Cabrera Marcia Janneth , Ordoñez Chacha Pablo Roberto , Reza‐Albarrán Alfredo Adolfo , Ordoñez Chacha Ana Karina , Acero Marcy Acosta , Rodas Serrano Agustin 
Published: August 2022

AbstractX‐linked hypophosphatemia (XLH) is a rare disexase in which patients present with severe bowing of the legs, joint pain, and mobility problems. XLH has major adverse repercussions on the quality of life.
Primary hypothyroidism resolves after switching from L‐thyroxine solid tablets to liquid oral substitution. A rare case without evidence of an underlying gastrointestinal malabsorption syndrome
Authors: Stupperich Sophie , Kotliarevskaia Jessica , Nies Reinhold , Paparoupa Maria , Wittig Andreas , Schuppert Frank 
Published: August 2022

AbstractA case of refractory primary hypothyroidism is presented. Despite laboratory‐guided hormonal substitution, the patient remained hypothyroid. Multiple diagnostic tests ruled out all known causes of levothyroxine malabsorption. Interestingly, clinical and laboratory responding was promptly achieved, after switching the application format from solid tablets to liquid formula.
Clustering‐based routing protocol using gray wolf optimization and technique for order of preference by similarity to ideal solution algorithms in the vehicular ad hoc networks
Authors: Kheradmand Behbod , Ghaffari Ali , Soleimanian Gharehchopogh Farhad , Masdari Mohammad 
Published: August 2022

SummaryIn a vehicular ad‐hoc network (VANET), each vehicle is equipped with an on‐board unit to communicate vehicle to vehicle or vehicle to fixed infrastructure. VANET technology is offered to provide many facilities to passengers and drivers, including safety, entertainment, mobile commerce, driver assistance, and emergency alarms. VANET has unique features such as high‐speed node mobility and network topology dynamics. These special features cause many problems such as increased transmission delays and packet loss. On the other hand, providing a good routing plan for VANET is a critical issue. Therefore, this article proposes a cluster‐based routing using in‐vehicle meta‐heuristic algorithms (CRMHA‐VANET) which has two phases. In the first stage, the vehicles are clustered and the most suitable cluster head (CH) is selected using the gray wolf optimization algorithm (GWO). In the next step, the next suitable CH is selected for data transmission in direct paths using the technique for order of preference by similarity to ideal solution (TOPSIS). The performance of the proposed method is analyzed through several criteria such as package delivery rate, end‐to‐end delay and throughput. CRMHA‐VANET results in a 10% to 25% improvement over all performance metrics, that is, packet delivery rate, latency, and throughput, over CRBP (clustering routing based on PSO [particle swarm optimization]), WCV (weight based clustering for VANET), and AODV‐CD methods.
Experimental study on shock‐shock interaction over double wedge controlled by surface arc plasma array
Authors: Kong Yakang , Li Jun , Wu Yun , Liang Hua , Guo Shanguang , Yang Hesen 
Published: August 2022

AbstractThe Mach 8 hypersonic shock‐shock interaction (SSI) over a double wedge controlled by the improved high‐energy surface arc discharge array (H‐SADA) have been investigated with high‐speed schlieren imaging. The H‐SADA with 10 actuators is installed on the first wedge to deposit energy into the hypersonic flow. In the hypersonic double wedge flow, the arrays of blast wave and thermal bubble induced by H‐SADA successively develop into a bump virtual profile and a wedge virtual profile, and the former makes complex SSI structure evolve into a bow shock, the latter makes it evolve into an oblique shock. Under the control of single discharge pulse, the disappearance process and the reconstruction process of SSI structure occur successively, and the whole process lasts for 0.2 ms. The H‐SADA works stably at frequency of 500 Hz in hypersonic flow, and there is little difference in the control process of each pulse, which means that the SSI structure disappears for 0.2 ms every 2 ms.