bluuebunny/crossref_metadata_2025_split huggingface dataset:
WITHDRAWN: Health Consequences of University Employees Post Covid-19 Vaccination at Palestinian Universities
Authors: Shouli Mustafa Mohammad , Shouli Khaila Mohammad , Issa Bilal Mohammad , Mohammad Ibrahim 
Published: June 2022

Abstract
The control of vaccine hesitancy comes with key protective measures against COVID-19 and excellent efficacy in clinical trials and effectiveness in real-world data. However, some people believe that vaccination is ineffective and that it causes health problems. We aimed to assess health consequences of university employees post Covid-19 vaccination at Palestinian Universities. The researchers conducted a descriptive study design between February and March 2021. A total of 310 university employees participated from six universities in Palestine: Nabulus University for Vocational & Technical Education, An-Najah National University, Modern University College, Birzeit University, Hebron University, Arab American University, and Al-Quds Open University. These universities were selected to be included in the study. A self-designed questionnaire was used for data collection and included the following parts: part1: personal characteristics of the university employees, Part II. Knowledge of university employees about covid-19 vaccination, Part III: Medical background of the participant, also their perception regarding receiving the COVID-19 vaccination. We found that less than the half of studied employees (41.3 %) were between 30<40 years with ±SD 38.6±7, more than three quarters, 79.4 %, were males; 41.9% of them recorded class II obesity, 72.6% suffered from chronic problems while 22.6% of them stayed in hospital post covid vaccination. based on the current study, there was a positive correlation between the total of university employees’ health consequence, perception, and their knowledge. Also, there was a highly statistical significant difference between the total perception and their knowledge. Recommendation: the study recommends publicity to enlighten people about what Covid-19 vaccination is, in order to correct the negative perception around the vaccine.
A comparative assessment of innovative hemispherical solar distillers with cylindrical and conical fins: An experimental approach
Authors: Attia Mohammed El Hadi , Kabeel Abd Elnaby , Abdel-Aziz Moataz M. , Abdelgaied Mohamed 
Published: June 2022

Abstract
Although the influence of fins on a basin's flat absorber will improve thermal performance and distillate production due to the increased heat transfer areas, many researchers are still interested in the problem of shading caused by fins, which reduces distiller productivity for some configurations of the fins designs. To obtain the best fin configurations that achieve the lowest shading effects and highest performance of hemispherical solar stills. The influences of absorbent cement layer with two types of fins (cylindrical and conical fins) with a diameter of 1.5 cm and a height of 3 cm at different gap spacing (3, 3.75, and 4.5 cm) were studied. To achieve these; three hemispherical solar stills were tested at same weather conditions, first is the conventional hemispherical still without fins (CHSWF) which represent the reference case. Second, is the cylindrical finned hemispherical still with gap spacing 3, 3.75, and 4.5 cm (CyFHS). Third, is the conical finned hemispherical still with gap spacing of 3, 3.75, and 4.5 cm (CoFHS). The results showed that, the cylindrical finned hemispherical still (CyFHS) productivity values are 5.55, 6.00, and 6.70 kg/m2, respectively, while conical finned hemispherical still (CoFHS) productivity values are 6.20, 6.65, and 7.15 kg/m2 at gap spacing of 3, 3.75, and 4.5 cm, respectively compared to 4.20 kg/m2 that was produced by CHSWF. The results showed that the use of conical fins achieves the highest performance of hemispherical still as a result of reducing the effect of shading. Whereas, the best configuration that achieves the highest performance is the use of conical fins with a gap spacing of 4.5 cm, where the rate of improvement is 70.24% compared to CHSWF
Encapsulation of Bifidobacterium animalis subsp. lactis through emulsification coupled with external gelation for the development of symbiotic systems
Authors: Frakolaki Georgia , Giannou Virginia , Tzia Constantina 
Published: June 2022

Abstract
In this work, a study regarding the encapsulation of the probiotic strain Bifidobacterium animalis subsp. lactis (BB-12) through emulsification followed by external gelation was performed. For this purpose, a variety of alginate-based blends, composed of conventional and novel materials, were used. The results demonstrated that alginate beads incorporating 1% carrageenan or 2% nanocrystalline cellulose provided great protection during refrigerated storage (50.3% and 51.1%, respectively), as well as in vitro simulation of the gastroinestinal tract (38.7 and 42.0%, respectively). The incorporation of glycerol into the formulation of the beads was proved successful for the protection of the BB-12 cells during frozen storage, increasing significantly their viability compared to the plain alginate beads (survival rate of 57.1% after 30 days at -18oC, instead of non-viable cells). Beads made of milk, alginate 1%, glucose 5% and inulin provided the best results at all cases. The microstructure of beads was assessed through SEM analysis.
Geometric-phase intraocular lenses with multifocality
Authors: Song Seok Ho 
Published: June 2022

Abstract
We demonstrate a new type of multifocal and extended depth of focus (EDOF) intraocular lenses (IOLs) embedding μm-thin geometric phase (GP) lens layers. As an emerging approach for lens phase design, the GP modulated IOLs outperform conventional diffractive IOLs in multifocality while completely avoiding the clinically undesirable demand for additional surface patterns to standard monofocal IOL designs. The number of foci and light splitting ratio of the GP IOLs are adjusted by changing the number of stacked GP layers and the thickness of each layer. Bifocal and trifocal GP IOLs are fabricated by radial alignment of anisotropic orientation in UV-curable liquid crystal polymers. After characterizing the defocus image and modulation transfer function of the GP IOLs, it is expected that GP IOLs will alleviate the most common problems associated with multifocal and EDOF IOLs, blurred vision and photic phenomena caused by light scattering and posterior capsule opacification.
PRDX6 knockout restrains the malignant progression of intrahepatic cholangiocarcinoma
Authors: li hong , Zhong lei Ru , Zhang kun Qi , chen xing Qi , Wu sheng Zheng , Shen xian Yu 
Published: June 2022

Abstract
Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis. The bifunctional protein peroxiredoxin6 (PRDX6), which has both calcium-independent phospholipase A2 (iPLA2) and glutathione peroxidase (GPx) activity, participates in the development of multiple tumors. However, the function and clinical significance of PRDX6 in ICC remain unclear. In this study, we characterized PRDX6 in both human ICC and thioacetamide-induced rat ICC. We found PRDX6 was significantly increased in ICC tissues, compared with the peritumoral tissues, and PRDX6 expression level was positively correlated with the malignant phenotype in ICC patients. Furthermore, PRDX6 genetic knockout significantly inhibited the tumor progression. By using RNA sequencing analysis, we found 127 up-regulated genes and 321 down-regulated genes after PRDX6 knockout. In addition, we noticed a significant repression in the Wnt7a/b cascade, which has been shown to play an important role in the occurrence of ICC. We confirmed that gene expressions in the Wnt7a/b cascade were inhibited in ICC tissues after PRDX6 knockout by using qRT-PCR and immunohistochemistry analysis. Collectively, our findings suggest that PRDX6 may promote ICC by regulating the
Identification of SBP Gene Family and Analysis of Expression Patterns under salt stress in Quinoa 1
Authors: Hou Wei-hai , Wang Jian-ling , Zhang Zong-yu , Haq Inzamam Ul , Feng Xibo 
Published: June 2022

Abstract
This study identified the SQUAMOSA Promoter Binding Proteins transcription factor SBP from the whole genome of Quinoa by analyzing the phylogenetic relationship, gene structure, chromosome location and gene replication, upstream cis-regulatory element, tissue expression, and construction of the SBP protein interaction network, as well as analyzing the characteristics of the SBP tissue expression pattern under salt stress. It serves as the foundation for the study and application of Quinoa SBP. The results showed that 23 genes of the CqSBP family were identified by bioinformatics analysis, and their amino acid physical and chemical properties showed diversity. The family proteins were hydrophilic, and the subcellular localization showed that 23 CqSBPs were located in the nucleus. The SBP family genes are unevenly distributed on the 12 chromosomes of Quinoa; the upstream cis-acting element analysis shows that there are 49 elements with plant hormones, stress, light response, and tissue-specific expression, and all CqSBPs contain one or more TATA box elements. Protein interaction network analysis shows that all CqSBP proteins appear in the known interaction network of Arabidopsis; the expression of different SBP genes in different organs and periods of Quinoa is different, and the expression of SBP genes has certain tissue specificity. The expression of CqSBP showed many changes under salt stress.
Time-Tracking-based Research of Drug Development in Pharmaceutical Fields ——A Case Study on Metformin
Authors: Wu Shengnan , Dong Jizong , Sun Yidan , Gao Jian , Tian Ruonan , Yu Qi 
Published: June 2022

Abstract
[Purpose/Significance]: At present, the bibliometric analysis methods used in the field of medicine are difficult to dig deeply into the text content, and most of them still stay in the stage of macroscopic analysis of the text. This paper adopts an analysis method of time-tracking, taking the text of metformin drugs as an example, through further mining of the text content, which is helpful to deeply explore the life cycle of drugs, research overview in different periods, changes in drug therapeutic uses, research hotspots, and explore the reuse potential of future drugs in new fields. [Method/Process]: In view of the shortcomings of the current research methods of text mining in the field of medicine, we extracted the inspection labels, subtitles and indexing terms of all metformin drugs texts included in the Pubmed database from 1959 to 2020. Using the correspondence analysis, cluster analysis and statistical methods to conduct dimensionality reduction of the data, and explore the information behind the text by a more microscopic way.[Result]: The paper revealed the characteristics and reasons of metformin drugs in the process of entire historical development. It was found that metformin has drug reposition value in the treatment of obesity, cardio-cerebrovascular diseases, polycystic ovary syndrome, anticancer, anti-inflammatory, altering gut microbiome composition and anti-aging, etc. And it predicted that metformin may have the drug reuse potential in the treatment of Alzheimer’s disease, neurodegenerative diseases and androdegenerative alopecia, etc. At the same time, the study of AMPK hypoglycemic mechanism will become the focus and hotspot of other hypoglycemic drug research and development institute. [Conclusion]: The experimental results prove that the analysis method of time-tracking can effectively test the drug research overview.
A Noval Approach towards Neuro Acoustic Loops &amp; their intervention in various Neuro Psychiatric Disorders
Authors: Aasim Shahzad , Ahmad Suhail , Butt Muheet , Wani Hilal , Fatima Rifat , Ganie Abdul , Dar Nizam Ud Din 
Published: June 2022

Abstract
Abstract

Acoustic signals are not transmitted to the brain wholly by contrivances of the ear but influences us through the mediums of skin, bones, and viscera. The ear is awfully subtle to vibrations in the air and conveys the tessellations of these vibrations in a form that the brain distinguishes as sound and speech. The medical devices are being developed that consume high-intensity focused acoustic signals as a non-invasive method for diagnostics and treatment of various psychiatric ailments. The major benefit of these sound or music & acoustic signals that offers the technique so readily to use in non-invasive therapy is its ability to breach deep into the human body and supply to a specific site thermal or mechanical energy with sub-millimetre accuracy. In this paper an attempt is made to study the intervention of these sound frequencies in general and their effects on neuro-psychiatric mechanisms and allied phenomenon. The quantification of specific frequencies (Acoustic loops) which will ameliorate the various disorders after their identification can also be correlated with various biochemical parameters that will be analysed with regards to the changes effected by these interventions. The proposed research work might provide a novel approach of treatment for neuro psychiatric disorders using the above stated measures using acoustic loops intervention that uses specific spectral frequencies to trigger effective and discernible changes in the subjects/patients suffering from neuropsychiatric ailments etc. The work intends to provide the effect of the above mentioned on 50 subjects which are taken in isolation wherein the results are quite demanding.
The Exports of Knowledge Intensive Services. A Complex Metric Approach
Authors: Leogrande Angelo , Costantiello Alberto , Laureti Lucio 
Published: June 2022

Abstract

In the following article, the value of the "Knowledge Intensive Services Exports in Europe" in 36 European countries is estimated. The data were analyzed through a set of econometric models or: Poled OLS, Dynamic Panel, Panel Data with Fixed Effects, Panel Data with Random Effects, WLS. The results show that “Knowledge Intensive Services Exports” is negatively associated, among others, with "Buyer Sophistication", "Government Procurement of Advanced Technology Products", and positively associated with the following variables i.e. "Innovation Index", "Sales Impacts" and "Total Entrepreneurial Activity". Then a clusterization with k-Means algorithm was made with the Elbow method. The results show the presence of 3 clusters. A network analysis was later built and 4 complex network structures and three structures with simplified networks were detected. To predict the future trend of the variable, a comparison was made with eight different machine learning algorithms. The results show that prediction with Augmented Data-AD is more efficient than prediction with Original Data-AD with a reduction of the mean of statistical errors equal to 55,94%.JEL Classification: O30; O31, O32; O33; O36.
Life cycle exposure to cyhalofop-butyl induced reproductive toxicity toward zebrafish
Authors: Zhou Tao , Wang Siwen , Li Dong 
Published: June 2022

Abstract
Cyhalofop-butyl (CyB) is an herbicide widely used in paddy fields, which may transfer to aquatic ecosystems and cause harm to aquatic organisms. In this study, zebrafish (Danio rerio) were exposed to CyB (0.1, 1 and 10 ug/L) related to the environment throughout its adult life cycle from embryo to sexual maturity. The effects of CyB on zebrafish growth, reproduction and offspring development were studied. It was found that female spawning was inhibited and adult male fertility decreased. In addition, we detected the expression of sex steroid hormones and genes related to hypothalamus-pituitary-gonad-liver (HPGL) axis. After 150days of exposure, the hormone balance of parent zebrafish (F0) was disturbed and the concentrations of 17β- estradiol (E2) and vitellogenin (VTG) in zebrafish were decreased. F1 embryos showed abnormal developmental results, including decreased heart rate, decreased body length, spontaneous motor inhibition, while the developmental abnormalities of F1 embryos were relieved when exposed to CyB-free clear water. The change of sex hormone is regulated by gene expression related to HPGL axis. These results confirmed that long-term exposure to CyB in the environmental concentrations can damage the reproductive capacity of F0 generation zebrafish by disrupting the transcription of genes related to HPGL axis, which may lead to abnormal development of F1. Overall, these data may provide a new understanding of the reproductive toxicity of zebrafish parents and offspring after long-term exposure to CyB.
Can green city branding support China's Sponge City Programme?
Authors: Mitchell Gordon , Chan Faith Ka Shun , Chen Wendy Y. , Thadani Dimple R. , Robinson Guy M. , Wang Zilin , Li Lei , Li Xiang , Mullins May-Tan , Chau Patrick Y. K. 
Published: June 2022

Abstract
China's Sponge City Programme (SCP) is one of the world's most ambitious sustainable urban drainage programmes. By 2030, Chinese cities must have 80% of their land drained by Blue–Green Infrastructure (BGI) to build critically needed flood resilience. Costs must be met from municipal and private finance, but BGI lacks the revenue streams of public assets like utilities, so has limited appeal to public–private partnerships. Finance options, including Green Bonds targeting institutional investors, and Payment for Urban Ecosystem Service schemes targeting local citizens and businesses, need developing. Green city branding could lever such finance but despite widespread use of green branding to attract investment, sponge branding strategies are immature, and alignment is needed in green branding between sponge project type (e.g., flagship and retrofit), financial instrument, and target financier, to develop differentiated brands that appeal to a diversity of SCP investors. With little grassroots input into city branding, and SCP problems of green gentrification, local support for SCP implementation may be at risk. This is concerning, because cities need local citizens and businesses to invest in the SCP to achieve the extensive retrofit needed, as retrofit (using small-scale BGI such as stormwater planters, de-paving, and raingardens) has little appeal for institutional investors.
Composite radial filter for removal of agrochemicals from agricultural runoff
Authors: Hansra G. D. S. , Singh J. P. , Sahota P. P. 
Published: June 2022

Abstract
A composite radial filter was designed, fabricated and developed for the removal of agrochemicals particularly N, P, K and bacteriological contaminant in runoff water from rice field for recharging aquifer. Zeolite (Z), activated charcoal (C), coarse sand (CS) and gravel (G) filter materials were placed in annular concentric rings of composite radial filter in different combination of thickness in the ratio of 1:2:4:4, 1:3:4:4, 1:2:2:4, 1:3:2:4 and 0:2:1:2 for five treatments (T1, T2, T3, T4 and T5) respectively. Sodium hypochlorite solution (5%) injected at the rate of 0.1 ml per unit discharge (lps) through chlorination unit at the outlet of the radial filter decreased bacteriological contamination to &lt;10 MPN per 100 ml from 1,100 MPN per 100 ml of filtered water. The performance of composite radial filter was evaluated by analyzing filtered water samples for four inflow/outflow rates viz. 0.42, 0.82, 1.24 and 1.66 lps. The T5 treatment consisting of filter materials C, CS and G with thickness of 20, 10 and 20 cm respectively was found to be the best compared to the other four treatments. The filter materials were washed with fresh water after 5 hours of filtration and reused.
Modifications of the C-Terminal Dipeptide of Angiotensin II Yielded a Novel Series of Analogues with Type II (AT2)
Receptor Selectivity
Authors: Cody Wayne L. , He John X. , Lunney Elizabeth A. , Humblet Christine C. , Lu Gina H. , Panek Robert L. , Dudley David T. 
Published: June 2022

Abstract:
Angiotensin II is a potent pressor agent acting through two distinct G-protein coupled receptors. The Type I (AT1) receptor is responsible for the pressor activity while the function of the Type II(AT2) receptor remains unclear. Specific modifications of the C-terminal dipeptide (-Pro7-Phe8) of angiotensin II with constrained aromatic (Tic) and hydrophobic (Oic) amino acids have led to analogues with negligible affinity for the AT1 receptor, but nanomolar affinity for the AT2 receptor. These compounds may provide useful tools to help delineate the physiological role of the AT2receptor.
Fairness in Mobile Phone–Based Mental Health Assessment Algorithms: Exploratory Study
Authors: Park Jinkyung , Arunachalam Ramanathan , Silenzio Vincent , Singh Vivek K 
Published: June 2022

Background
Approximately 1 in 5 American adults experience mental illness every year. Thus, mobile phone–based mental health prediction apps that use phone data and artificial intelligence techniques for mental health assessment have become increasingly important and are being rapidly developed. At the same time, multiple artificial intelligence–related technologies (eg, face recognition and search results) have recently been reported to be biased regarding age, gender, and race. This study moves this discussion to a new domain: phone-based mental health assessment algorithms. It is important to ensure that such algorithms do not contribute to gender disparities through biased predictions across gender groups.

Objective
This research aimed to analyze the susceptibility of multiple commonly used machine learning approaches for gender bias in mobile mental health assessment and explore the use of an algorithmic disparate impact remover (DIR) approach to reduce bias levels while maintaining high accuracy.

Methods
First, we performed preprocessing and model training using the data set (N=55) obtained from a previous study. Accuracy levels and differences in accuracy across genders were computed using 5 different machine learning models. We selected the random forest model, which yielded the highest accuracy, for a more detailed audit and computed multiple metrics that are commonly used for fairness in the machine learning literature. Finally, we applied the DIR approach to reduce bias in the mental health assessment algorithm.

Results
The highest observed accuracy for the mental health assessment was 78.57%. Although this accuracy level raises optimism, the audit based on gender revealed that the performance of the algorithm was statistically significantly different between the male and female groups (eg, difference in accuracy across genders was 15.85%; P<.001). Similar trends were obtained for other fairness metrics. This disparity in performance was found to reduce significantly after the application of the DIR approach by adapting the data used for modeling (eg, the difference in accuracy across genders was 1.66%, and the reduction is statistically significant with P<.001).

Conclusions
This study grounds the need for algorithmic auditing in phone-based mental health assessment algorithms and the use of gender as a protected attribute to study fairness in such settings. Such audits and remedial steps are the building blocks for the widespread adoption of fair and accurate mental health assessment algorithms in the future.