bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling and optimization of dry reforming of methane over Ni-Co/Al 2 O 3 -ZrO 2 catalyst coating via PVD method in a microchannel reactor using Box-Behnken design
Authors: moradi Mohamadgafar , Moradi Gholamreza , Heydarinasab Amir , Rashidi Alimorad 
Published: April 2022

Abstract
In the current study, to optimize dry reforming of methane, coating Ni-Co /Al2O3-ZrO2 nanocatalyst was explored in a microchannel reactor using physical vapor deposition (PVD) method. The Box-Behnken design was implemented to examine initial feed conversion (CO2, CH4), H2:CO molar ratio and catalyst deactivation. Using response surface method, optimization of coating time (2 min, 3 min, and 4 min), Co/Ni weight percentage (25%, 50%, and 75%), and reaction temperature (650 °C, 700 °C, 750 °C) was explored. The experiments were conducted when the temperature ranged from 650 °C to 750 °C, the pressure was equal to 1 atm, and CH4/CO2 molar ratio was equal to 1. Also, Grazing incidence X-ray diffraction (GIXRD), field emission scanning electron microscopy (FESEM), and energy-dispersive X-ray (EDX), were used to identify catalyst features. FESEM images showed that catalyst film activity highly depended on coating time in that increasing coating time yielded more uniform and properly dispersed catalyst particles. When deposition time was 4 min, nearly 95% of the particles had a size of 10-20 nm (with an average of 15.41 nm). EDX analysis also indicated that all elements were uniformly and properly dispersed on the substrate. GIXRD analysis further demonstrated that increasing Co/Ni weight percentage up to 50% would result in reduced particle size as well as higher activity, stability, and resistance to carbon deposition. Conversely, greater Co weight percentages led to relatively larger particle size and lower catalytic activity given that the active sites were synthesized and the Ni particles were covered by the Co-rich phase. Concerning the optimum condition, the highest amounts of initial CH4 conversion (95.94%), initial CO2 conversion (97.87%), H2:CO molar ratio (0.96), and catalyst deactivation (1.99%) were registered when the coating time was 3.87 min, Co/Ni weight percentage was 45.04%, and the reaction temperature was 750 °C. The values predicted in the proposed model closely aligned with the results obtained through experimental tests.
Effect of a Semi-rigid Ankle Brace on the In Vivo Kinematics and Muscle Activity of Patients with Functional Ankle Instability Duing Simulated Ankle Sprain
Authors: Zhang Gonghao , Cao Shengxuan , Zhang Guoning , Zhang Yangyang , Xiong Li , Huang Ping , Wang Chen , Zhang Chao , Ma Xin , Ji Yunhan 
Published: April 2022

Abstract
Background
Ankle braces can effectively decrease the incidence of recurrent ankle sprain; however, whether the brace can decrease the severity of sprain and its related mechanism during sprain remain unknown.
Methods
12 patients with functional ankle instability (FAI) (7 males and 5 females) and 10 healthy subjects (5 males and 5 females) were enrlled in this study. All of the subjects walked on a custom-built tilting platform that offered a 30° inversion to mimic the inversion of ankle sprain. We collected the kinematic and sEMG data of patients with FAI with or without ankle brace and normal controls six times.
Results
The FAI without brace group showed significantly higher maximum inversion angles and average inversion velocities than the control group (P < 0.001). The FAI with brace group revealed significantly lower maximum inversion angles and average inversion velocities than the FAI without brace group (P < 0.001); this group also showed significantly higher maximum external rotation angle and average external rotation velocities than the FAI with brace (P < 0.001) and control (P < 0.001) groups. The FAI with brace group indicated significantly lower average EMGPrep (P = 0.047), EMGTilt (P = 0.037), and EMGafterTilt (P = 0.004) of the peroneus longus (PL) than the FAI without brace group.
Conclusions
The ankle brace could effectively decrease inversion angles and their velocities and increase external rotation angles and their corresponding velocities during ankle sprain in patients with FAI. It could also decrease the activity of the PL muscle during ankle sprain.
Neutrophil CD64 index for diagnosis of infectious disease in the pediatric ICU: a single-center prospective study
Authors: Cao lulu , Wang Wei-Wei , Zhao Li , Li Ji-Ru , Kong Xiang-Mei , zhu Yueniu , zhu xiaodong 
Published: April 2022

Abstract
Background: Infection is a major cause of death in children, and it is particularly important to identify biological indicators of early infection. Previous studies showed that the neutrophil CD64 (nCD64) index may be a useful biomarker for infection. The purpose of this study was to investigate use of the nCD64 index to identify infection in children from a pediatric ICU (PICU) in China.Methods: This prospective observational study enrolled 201 children who were admitted to our PICU and divided them into an infection group and a non-infection group. In each patient, C-reactive protein (CRP), nCD64 index, procalcitonin (PCT), and white blood cell count were measured during the first 24 h after admission. Receiver operating characteristic (ROC) analyses were used to determine the sensitivity, specificity, and diagnostic value of the nCD64 index for infection. Results: Among all 201 children, the infection group had greater levels of CRP, nCD64 index, and PCT (all p < 0.05). ROC analysis indicated the nCD64 index had a sensitivity of 68.8%, specificity of 90.7%, accuracy of 80.5%, and an optimal cut-off value of 0.14, which had better diagnostic value than CRP or PCT. For children with postoperative fever, the nCD64 index can also distinguish SIRS from infection, with accuracy of 79%. Conclusions: The nCD64 index is a useful biomarker for the diagnosis of early infection in children admitted to the PICU.
A prospective interventional study of recombinant human interleukin-11 mouthwash in chemotherapy-induced oral mucositis
Authors: Wei Hangping , Dong Xiaofang , Wei Juan 
Published: April 2022

Abstract
Background: This prospective interventional study aimed to evaluate and analyse the efficacy of rhIL-11 mouthwash compared to Rehabilitation New Liquid or blank control in treating and preventing oral mucositis (OM) in patients receiving chemotherapy. Materials and Methods: In total, 50 patients in the treatment group and 62 patients in the prevention group were included. Subsequently, each group was divided into an experimental group and a control group. In the treatment group, the experimental patients received recombinant human interleukin-11 (rhIL-11) mouthwash, whereas the control group received Rehabilitation New Liquid. In the prevention group, experimental patients still received rhIL-11 mouthwash based on routine oral care, whereas the control group only received routine oral care. Meanwhile, we observed and recorded the efficacy in the treatment group, and the occurrence and grades of OM in the prevention group. Results: Through statistical analysis, the results showed that on the seventh day of treatment, the experimental group showed more improvement compared to the control group, and it was statistically significant (P= 0.032) (Table 2). The average healing time in the experimental group (3.59 ± 1.927 days) was shorter than that in the control group (4.96 ± 2.205 days; P=0.024) (Table 3). In the prevention group, we observed the incidence of oral mucositis. No significant differences were found in the occurrence and grades of OM in the experimental and control groups (P=0.175; Table 4). Conclusion: Our preliminary results indicate that rhIL-11 mouthwash may be an available option to treat OM, especially in severe cases. However, there is no advantage in prevention.
Sleep Duration is Associated with Caudate Volume and Executive Function
Authors: Jones Nicole F , Ikuta Toshikazu 
Published: April 2022

Abstract
The role of the caudate volume in sleep has been implicated. Previous literature showed that the caudate volume is associated with longer habitual sleep duration in older adults. However, the association between sleep duration and caudate volume remains unknown in the younger population. In this study, we examined the caudate volume in youth to older adults (10 to 85 years old) with a greater sample size (N = 463). The volumetric size of the caudate nucleus showed significantly positive association with habitual sleep duration. Sleep duration showed significant association with executive function performance. However, caudate volume did not significantly predict executive function. Our results suggested that sleep duration is associated with the caudate volume and executive function. It is also suggested that there are some external mechanisms that modulate executive function which prevent the caudate-sleep relation’s effect on executive function.
Novel tRNA-like transcripts from the NEAT1-MALAT1 genomic region critically influence human innate immunity and macrophage functions
Authors: Gast Martina , Nageswaran Vanasa , Kuss Andreas , Tzvetkova Ana , Wang Xiaomin , Mochmann Liliana , Ramezani-Rad Pegah , Weiss Stefan , Simm Stefan , Zeller Tanja , Voelzke Henry , Hoffmann Wolfgang , Völker Uwe , Felix Stefan , Dörr Marcus , Beling Antje , Skurk Carsten , Leistner David-Manuel , Rauch Bernhard , Hirose Tetsuro , Heidecker Bettina , Klingel Karin , Nakagawa Shinichi , Poller Wolfram , Swirski Filip , Haghikia Arash , Poller Wolfgang 
Published: April 2022

Abstract
The evolutionary conserved NEAT1-MALAT1 gene cluster generates large noncoding transcripts remaining nuclear, while tRNA-like transcripts (mascRNA, menRNA) enzymatically generated from these precursors translocate to the cytosol. NEAT1-/- and MALAT1-/- mice display massive atherosclerosis and vascular inflammation.

Here, we identify the tRNA-like molecules as critical components of innate immunity. They appear as prototypes of a new class of noncoding RNAs distinct from others (miRNAs, siRNAs) by biosynthetic pathway and intracellular kinetics. CRISPR-generated human ΔmascRNA and ΔmenRNA monocytes/macrophages display defective innate immune sensing, loss of cytokine control, imbalance of growth/angiogenic factor expression impacting upon angiogenesis, and altered cell-cell interaction systems. Antiviral response, foam cell formation/oxLDL uptake, and M1/M2 polarization are defective in ΔmascRNA/ΔmenRNA macrophages, defining the tRNA-like molecules’ first described biological functions.

menRNA and mascRNA represent novel components of innate immunity arising from the noncoding genome. Their NEAT1-MALAT1 region of origin appears as archetype of a functionally highly integrated RNA processing system.
Internally versus Externally Trained Residents and Fellows Hired as Attendings at a Large Integrated Healthcare System: A 20-year Retrospective Study
Authors: Chien Gary W. , Wertheimer Stephen M. , Harris Jerad A. , Collins J. Craig , Spiegel Nancy H 
Published: April 2022

Abstract
Background: There remains a question of whether graduates trained internally are different than those trained elsewhere. We examine the difference between physicians trained within our Graduate Medical Education (GME) programs versus physicians trained elsewhere. Our large integrated healthcare system is unique in addressing this objective due to its large physician labor hiring needs across different specialties of GME graduates.Methods: A retrospective review was performed from Jan 2000 to August 2020 of Kaiser Permanente Southern California (KPSC) physicians hired: KPSC GME trained versus non-KPSC GME trained. We examined five variables: retention, leadership (current or historical), physician relations cases, member appraisal of physician and provider services survey (MAPPS) scores, and rate of board certification. Chi-square test of proportions was used for comparison, p<0.05 was significant. Results: From Jan 2000 to August 2020, 2,940 residents and fellows graduated from KPSC GME programs, of which 1,127 (38%) were hired on at KPSC as full time attendings. Across all five metrics (Retention 82% vs 76% (p=< 0.01), Leadership [current 13% vs 10% (p=<0.01)or historical 17% vs 14% (p=0.01)], Physician Relations 23% vs 26% (p=0.04), MAPPS 75% vs 69% (p=<0.01), and Board Certification 81% vs 74% (p=<0.01)), KPSC outperformed non-KPSC GME trained physicians to a statistically significant degree. Conclusions: We have shown that an internally sponsored GME program can represent an opportunity for recruitment of physicians that may have higher retention rates, higher probability of being physician leaders, decreased likelihood of physician relations issues, improved patient satisfaction, and increased rates of board certification.
YTHDC1 serves as a potential therapeutic target and is linked with the immune microenvironment in Pan cancer
Authors: Wen Diguang , Lu Jiao , Liu Zuojin , Li Yue 
Published: April 2022

Abstract
Previous studies have shown that m6A is involved in many aspects surrounding tumor progression, but the role of classic m6A reading protein YTHDC1 in the progression and immune microenvironment among multiple cancers remains unclear. The aim of the present study was to investigate the role of YTHDC1 in the Pan cancer tumor progression and immune microenvironment. The YTHDC1 expression pattern and prognostic value were first detected in Pan cancer in the public data. The role of YTHDC1 in Pan cancer was analyzed by bioinformatic analysis. The association between YTHDC1 expression and immune cell infiltration and immune inhibitory markers was analyzed. The expression of YTHDC1 in hepatocellular carcinoma was verified by independent datasets and clinical samples, and its function was explored in vitro. YTHDC1 is positive expression in all of 33 types tumors, and its expression and phosphorylation modification have abnormal changes across varieties tumors based on the analysis of TCGA and CPTAC databases. Prognostic analysis also showed that YTHDC1 was closely related to the prognosis of patients in some tumors such as BLCA and KIRC (p < 0.05). Finally, independent data sets, clinical samples and in vitro experiments verified the high expression of YTHDC1 in liver cancer and its ability to promote tumor and immune microenvironment. In conclusion, YTHDC1 has potential functions in tumors, can be used as a prognostic marker for a variety of tumors, and is related to the formation of the immune microenvironment. Out of pan-cancer, YTHDC1 promotes liver cancer progression.
Searching behavior and prey preference by the predatory mirid bug Tupiocoris cucurbitaceus, a potential biocontrol agent of tomato crops in Argentina
Authors: Cáceres Rocío Isabel Montiel , Rocca Margarita , Luna María Gabriela 
Published: April 2022

Abstract
Generalist arthropod predators usually exhibit a degree for prey acceptance and this behavior can ultimately determine their potential as biocontrol agents. The South American tomato leafminer Tuta absoluta is a key pest of tomato crops worldwide. Biological control has gained interest as a reliable and environmentally safe pest management technique, and particularly the use of predatory mirid bugs has shown positive results to control T. absoluta and other horticultural pests in several countries. In a laboratory study we assessed: 1) prey searching behavior and 2) feeding preference of late nymphs and adults of both sexes of Tupiocoris cucurbitaceus, a mirid bug present in Argentinian tomato crops with the aim of deepen its status as a biocontrol candidate of T. absoluta. Predatory individuals were offered simultaneously three patches of prey: the target patch (TP) with T. absoluta eggs and two non-target patches (NTP) with Ephestia kuehniella eggs and Trialeurodes vaporariorum late-instar nymphs. First, a 30-min trial was analyzed using EthoVision® software in which we found that mirids equally accepted TP and NTP, and only nymphs preferred to feed on T. absoluta eggs. After 24 h, predatory nymphs consumed proportionally more of the three prey offered, but mainly lepidopteran eggs. These results prove that T. absoluta eggs can be part of the prey diet of T. cucurbitaceous especially for the nymphal stage. Further studies on prey availability in field conditions are needed to use T. cucurbitaceus as a biocontrol agent of T. absoluta in Argentina.
Analysis of Genetic Contribution to Thoracic Aortic Aneurysm or Dissection in a Prospective Cohort of Familial and Sporadic Cases in East China
Authors: Duan Yanyu , Xiong Jianxian , Lai Zhenghong , Zhong Yiming , Tian Chengnan , Du Zhiming , Luo Zhifang , Yu Junjian , Li Wentong , Xu Weichang , Wang Yabing , Ding Ting , Zhong Xuehong , Pan Mengmeng , Qiu Yu , Lan Xuemei , Chen Taihua , Li Peijun , Liu Kang , Gao Meng , Hu Yanqiu , Liu Ziyou 
Published: April 2022

Abstract
Background. Thoracic aortic aneurysm or dissection (TAAD) is a group of life-threatening diseases. Genetic etiology lead to some special characteristics on age of onset, clinical phenotype, and timing of intervention. Herein, we initiated a prospective trial to determine the prevalence of pathogenic variants in TAAD patients and to elucidate the traits related to harboring pathogenic variants. One hundred and one unrelated TAAD patients were sequenced and analyzed for 23 TAAD associated genes using a targeted PCR and next generation sequencing-based panel. Results. A total of 47 variants were identified in 52 TAAD patients (51.5%) including 6 pathogenic, 1 likely pathogenic and 40 variants of uncertain significance. The pathogenic or likely pathogenic (P/LP) variants in 4 disease-causing genes were carried by 1 familial and 6 sporadic cases (6.9%). Besides one familial TAAD, the FBN1 gene also harbored more than half of the P/LP variants in sporadic ones. The individuals with the age of onset less than 50 years and normotension massively increased the genetic risk. Conclusions. The TAAD cases with younger age at diagnosis and normotension were more likely to carry a P/LP variant, thus routine genetic testing will be beneficial to better prognosis through a genetically personalized care prior to acute rupture or dissection.
A new perspective on increased emergence of Central Pacific ENSO
in the recent two decades
Authors: Chen Shangfeng , Chen Wen , Yu Bin , Wu Renguang , Graf Hans , Chen Lin 
Published: April 2022

Abstract
In this study, we provide a new perspective on the recent increased emergence of the central Pacific type of El Niño and Southern Oscillation (ENSO). Our results indicate that early-spring Aleutian Low (AL) intensity has a remarkable impact on the following winter ENSO especially after the late-1990s. Decrease (increase) in the early-spring AL strength tends to induce an anomalous cyclone (anticyclone) over subtropical North Pacific via wave-mean flow interaction. The anomalous cyclone (anticyclone) leads to sea surface temperature (SST) increase (decrease) in the equatorial Pacific in the following summer via wind-evaporation-SST feedback and trade wind charging mechanism, which further contributes to succeeding central Pacific-like El Niño (La Niña). This remarkable AL’s impact on ENSO is attributable to enhancement of the background trade winds, which is related to changes of both the AMO and NPGO from positive to negative phases around the late-1990s. In contrast, global warming is suggested to have a negative effect on the recent increased connection of the early-spring AL with the following winter ENSO. The results offer the potential to advance our understanding of the factors that explain decrease of the prediction skill of ENSO since the late-1990s.
Aging Sexual Knowledge and Attitude Scale: Turkish validity and reliability study
Authors: KURT HASAN ANIL , YILMAZ Büşra , ALAN Handan , ALAN Cabir 
Published: April 2022

Abstract
Objectives: It is designed to test the Turkish version of ASKAS's validity and reliability for use with older people, health professionals, and people who influence older people. Methods: Language and content validity, item analysis, exploratory and confirmatory factor analysis, and internal consistency coefficients were evaluated in this study. Results: It was decided to omit two items from the scale's knowledge subscale, and the three-factor structure of the attitude subscale was found to be within the range of acceptable fit indices. Conclusions: The Turkish version of ASKAS was determined to be valid, reliable, and applicable in practice.
Prognostic value of estimated glucose disposal rate in non-ST-segment elevation acute coronary syndrome cases administered percutaneous coronary intervention
Authors: Liu Chi , Zhao Qi , Ma Xiaoteng , Cheng Yujing , Sun Yan , Zhang Dai , Liu Xiaoli , Zhou Yujie 
Published: April 2022

Abstract
Background: Estimated glucose disposal rate (eGDR) is highly associated with all-cause mortality in type 2 diabetes mellitus (T2DM) cases administered coronary artery bypass grafting (CABG). However, the predictive ability of eGDR for poor outcome in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) cases diagnosed by percutaneous coronary intervention (PCI) remains unknown.Methods: Totally 2308 NSTE-ACS patients administered PCI at Beijing Anzhen Hospital from January to December 2015 were enrolled in this study. Major adverse cardiac and cerebral events (MACCEs) were considered the primary endpoint. eGDR was calculated by waist circumference (WC) (eGDRWC) or body mass index (BMI) (eGDRBMI).Results: The incidence of MACCEs was markedly higher in cases with low eGDR compared with the high eGDR group. Multivariable analysis showed hazard ratios (HRs) for eGDRWC and eGDRBMI of 1.152 (95% confidence interval [CI] 1.088-1.219; P<0.001) and 0.998 (95%CI 0.936-1.064; P=0.957). Addition of eGDRWC to a model that includes currently recognized cardiovascular risk factors markedly enhanced its predictive power (Harrell’s C-index, eGDRWC versus Baseline model, 0.778 versus 0.768, P=0.003; continuous net reclassification improvement (continuous-NRI) 0.125, P<0.001; integrated discrimination improvement (IDI) 0.016, P<0.001).Conclusion: Low eGDR independently predicts adverse outcome in NSTE-ACS cases administered PCI.
Amelioration of ionic conductivity (303K) with the supplement of MnO2 filler in the chitosan biopolymer electrolyte for magnesium batteries.
Authors: Helen Adlin , Selvin Christopher , Lakshmi D. , Diana M.Infanta 
Published: April 2022

Abstract
In the present work, the significance of adding MnO2 filler towards development of biopolymer electrolyte, chitosan with enhanced ionic conductivity has been reported. The complexation that has taken place with the inclusion of MgNO3.6H2O salt and MnO2 filler in the chitosan matrix has been investigated through the Fourier Transform Infra Red (FTIR) spectra analysis. Further, the transport parameter values such as number of charge carrier densities (n), mobility (µ) and diffusion coefficient (D) have been calculated from the deconvoluted FTIR spectra. X-Ray Diffraction (XRD) and Differential Scanning Calorimetric (DSC) examination revealed that the inclusion of filler significantly reduced the degree of crystallinity and the glass transition Tg values respectively. These findings show that the inclusion of filler increases the segmental mobility of the polymer chains, allowing for faster ion transport. The conduction properties of the prepared electrolytes has been determined using Alternating Current (AC) impedance analysis, with the electrolyte containing 60 wt% magnesium salt (2.6 ± 0.08) х 10− 4 S cm− 1 achieving the maximum ionic conductivity value at room temperature (303K). This value is further increased by one order of magnitude with the addition of MnO2 filler into the polymer matrix (1.25 ± 0.09) х 10− 3 S cm− 1. To elucidate the individual contributions of ions and electrons in the conduction process, the Direct Current (DC) polarisation method has been used to determine the transference number (tion) of the produced electrolytes. The filler added chitosan polymer exhibits an extended electrochemical stability window, 1.7 V as determined by Linear Sweep Voltammetry (LSV).