bluuebunny/crossref_metadata_2025_split huggingface dataset:
That's an Order! How the Quest for Efficiency Is Transforming Judicial Cooperation in Europe
Authors: Brekke Stein Arne , Naurin Daniel , Šadl Urška , López‐Zurita Lucía 
Published: June 2022

AbstractEffective procedural arrangements allow courts to reconcile conflicting demands of timely justice and sound legal argument. In the context of the European Union, conflict between these demands emerged most acutely in the face of paralyzing delays in the preliminary reference procedure. It was partly solved by Article 99 of the Rules of Procedure. The provision allowed the European Court of Justice to dispose of repetitive and legally undemanding cases with a reasoned order in lieu of a judgment. This article analyses all published orders of the European Court of Justice to examine the use and the implications of Article 99 of the Rules of Procedure. It is the first article to do so. We find that the Court resorts to orders to save time and to halt repeated questions from the courts of a single Member State.
Effects of whole grain intake on glycemic control: A meta‐analysis of randomized controlled trials
Authors: Li Zhiwei , Yan Hongjia , Chen Liying , Wang Yixing , Liang Jingjing , Feng Xin , Hui Suocheng , Wang Kai 
Published: June 2022

AbstractAims/IntroductionAlthough mounting evidence has suggested an inverse association between the intake of whole grains and glycemic control, findings from randomized controlled trials are still conflicting. The current study was carried out to evaluate the effect of medium/long‐term whole grain intake on glycemic control in metabolic syndrome and healthy populations.Materials and MethodsA literature search was carried out to identify qualified studies up to July 2021. The effects of whole grain consumption on glycemic control were calculated using a fixed effects model. Subgroup analysis was used to study whether grouping factors were important influencing factors of heterogeneity between research results.ResultsA total of 32 randomized controlled trials with 2,060 participants were included in the analyses. Whole grain consumption showed a significant inverse regulatory effect on fasting glucose concentration, but no significant effect was found for other glycemic measures, such as fasting insulin, homeostatic model assessment for insulin resistance, glycated hemoglobin and 2‐h glucose, in the pooled analysis. Through subgroup analyses, a significant decrease in fasting glucose concentration was observed for studies with a higher whole grain dose, with participants of normal glycemia, and with mixed types of whole grain.ConclusionsMedium‐/long‐term whole grain intake reduced the fasting glucose concentration compared with similar refined foods. Appropriate intervention dose and accurate population selection might be the key links for whole grain consumption to exert its glycemic control effect.
Exploring societal perspectives on priorities at the end of life in South Korea using Q‐methodology
Authors: Kim Ick‐Jee 
Published: June 2022

AbstractAimTo explore societal perspectives on priorities at the end of life in South Korea, an Asian country with high characteristics of Confucian culture. Based on this understanding, this study proposes strategies for establishing well‐dying Confucian heritage cultures.MethodsQ‐methodology, suitable for analyzing human subjectivity, was used in this study. Thirty‐four Q‐statements were extracted from the 170 Q population, which were gathered from literature reviews and online resources. Participants were 33 people expected to present diverse views of priorities at the end of their lives. The data were analyzed with principal component analysis and varimax rotations using the PQMethod software.ResultsFour distinct perspectives on priorities at the end of life in South Korea were identified: “Emphasizing the right to self‐determination,” “Avoiding burdening the family,” “Putting life first,” and “Connotations with a complex perspective.”ConclusionsThis study provides strategies for preparing various nursing interventions or policies for the establishment of a well‐dying culture based on the four identified perspectives on priorities at the end of life, especially in countries with Confucian heritage cultures.
A method for the fast and photon‐efficient analysis of time‐domain fluorescence lifetime image data over large dynamic ranges
Authors: Laine Romain F. , Poudel Chetan , Kaminski Clemens F. 
Published: June 2022

AbstractFluorescence lifetime imaging (FLIM) allows the quantification of sub‐cellular processes in situ, in living cells. A number of approaches have been developed to extract the lifetime from time‐domain FLIM data, but they are often limited in terms of speed, photon efficiency, precision or the dynamic range of lifetimes they can measure. Here, we focus on one of the best performing methods in the field, the centre‐of‐mass method (CMM), that conveys advantages in terms of speed and photon efficiency over others. In this paper, however, we identify a loss of photon efficiency of CMM for short lifetimes when background noise is present. We subsequently present a new development and generalization of CMM that provides for the rapid and accurate extraction of fluorescence lifetime over a large lifetime dynamic range. We provide software tools to simulate, validate and analyse FLIM data sets and compare the performance of our approach against the standard CMM and the commonly employed least‐square minimization (LSM) methods. Our method features a better photon efficiency than standard CMM and LSM and is robust in the presence of background noise. The algorithm is applicable to any time‐domain FLIM data set.
Impact of early postoperative indwelling urinary catheter removal: A systematic review
Authors: Nollen Jeanne‐Marie , Pijnappel Laury , Schoones Jan W. , Peul Wilco C. , Van Furth Wouter R. , Brunsveld‐Reinders Anja H. 
Published: June 2022

AbstractBackgroundIndwelling urinary catheters (IDUCs) are associated with complications and early removal is therefore essential. Currently, it is unknown what the effect of a specific removal time is and what the consequences of this removal time are.Research questionTo present an overview of the available evidence to determine the effects of three postoperative IDUC removal times (after a certain number of hours, at a specific time of day and flexible removal time) on the development of complications in hospital.MethodsPubMed, Medline, Embase, Emcare and Cochrane Central Register of Controlled Trials were searched till 6 June, 2021. Studies were included that described the effect of the removal time in relation to re‐catheterisation, urinary tract infections (UTIs), ambulation time, time of first voiding and hospital stay. The quality of the studies was assessed with the Newcastle‐Ottawa Scale and the Cochrane Effective Practice and Organisation of Care. A narrative descriptive analysis was performed. PRISMA guidelines were followed in reporting this review.ResultsTwenty studies were included from which 18 compared removal after a number of hours, 1 reported on a specific removal time and 1 reported on both topics. The results were contradicting regarding the hypothesis that later removal increases the incidence of UTIs. Earlier removal does not lead to a higher re‐catheterisation rate while immediate removal is beneficial for reducing the time to first ambulation and shortening the hospital stay. Studies reporting on specific removal times did not find differences in outcomes. No study addressed flexible removal time.ConclusionsThere is inconclusive evidence that earlier removal results in less UTIs, despite the incidence of UTIs increasing if the IDUC is removed ≥24 h. Immediate or after 1–2 day(s) removal does not lead to higher re‐catheterisation rates while immediate removal results in earlier ambulation and shorter length of hospital stay.Implications of key findingsNurses should focus on early IDUC removal while being aware of urinary retention.
Thecomforter‐in‐chief: How two traumatic experiences shaped president joe Biden's first 100 days
Authors: McAdams Dan P. 
Published: June 2022

AbstractObjectiveIn the first 100 days of his U.S. presidency, Joe Biden sought to comfort Americans who had lost loved ones to the pandemic and to initiate a surprisingly progressive policy agenda. I interpret these two cardinal features of his early presidency in terms of two traumatic losses in Biden's personal life, contextualizing the argument within a 3‐tiered model of personality.MethodThis psychobiography of a single case mainly follows an inductive, grounded‐theory approach that aims to find patterns in the data that both explain a life and link to evidence‐based constructs in psychological science.ResultsAs Biden understands his own life story, the deaths of his wife and daughter in 1972 and first‐born adult son in 2015 forged an empathic sensibility that enables him to connect deeply with other Americans through shared grief and pain. These two traumatic events also inform the uniquely conciliatory approach he followed to instigate social change.ConclusionsThe first 100 days of the Biden presidency provide a striking example of how a particular person's life history comes to meet the broader historical moment. The findings have implications for how personality researchers think about redemptive life stories and the nature of late‐life narrative identity.
The transmembrane α‐helix of LptC participates in LPS extraction by the LptB2FGC transporter
Authors: Wilson Andrew , Ruiz Natividad 
Published: June 2022

AbstractLipopolysaccharide (LPS) is an essential component of the outer membrane of most Gram‐negative bacteria that provides resistance to various toxic compounds and antibiotics. Newly synthesized LPS is extracted from the inner membrane by the ATP‐binding cassette (ABC) transporter LptB2FGC, which places the glycolipid onto a periplasmic protein bridge that connects to the outer membrane. This ABC transporter is structurally unusual in that it associates with an additional protein, LptC. The periplasmic domain of LptC is part of the transporter's bridge while its transmembrane α‐helix intercalates into the LPS‐binding cavity of the core LptB2FG transporter. LptC’s transmembrane helix affects the in vitro ATPase activity of LptB2FG, but its role in LPS transport in cells remains undefined. Here, we describe two roles of LptC’s transmembrane helix in Escherichia coli. We demonstrate that it is required to maintain proper levels of LptC and participates in coupling the activity of the ATPase LptB to that of its transmembrane partners LptF/LptG prior to loading LPS onto the periplasmic bridge. Our data support a model in which the association of LptC’s transmembrane helix with LptFG creates a nonessential step that slows down the LPS transporter.
Comparison of three different treatment methods for traumatic and Iatrogenic peripheral artery pseudoaneurysms
Authors: Zhao Baocheng , Zhang Jinli , Ma Jianxiong , Huang Mei , Li Jin , Ma Xinlong 
Published: June 2022

ObjectiveTo compare the efficacy of open surgery (OS), endovascular interventions (EIs), and ultrasound‐guided thrombin injection (UGTI) for the treatment of peripheral arterial pseudoaneurysms (PAs).MethodsFrom January 1, 2001, to February 10, 2021, 38 patients diagnosed with traumatic and iatrogenic PAs treated with OS, EI, and UGTI were retrospectively analyzed. There were 18 females and 20 males, with an age of 56.47 ± 14.08 years (range,17–87 years). Anesthesia modality, operation duration, blood transfusion, duration of hospital stay, primary and secondary success rates, and complication rate were used to evaluate the surgical outcomes.ResultsThere were 11 cases under regional anesthesia and 4 under general anesthesia in OS group, 9 under regional anesthesia and 1 under general anesthesia in EI group, and no regional or general anesthesia was required in UGTI group. There was no significant differences between any two groups (χ2 = 39.80, p < 0.05). The blood tranfusion amount (units) were 3.6 ± 6.0, 0.8 ± 2.5, 0.0 ± 0.0 for OS, EI, and UGTI groups, respectively, with significant difference between OS and UGTI groups (F = 3.03, p < 0.05). The operation duration (minutes) of OS, EI, and UGTI groups were 80.0 ± 41.9, 56.0 ± 8.4, and 22.7 ± 5.3, respectively, with significant difference between any two groups (F = 15.69, p < 0.05). The duration of hospital stay (days) were 47.7 ± 39.0, 31.5 ± 17.6, and 16.3 ± 9.5, repectively, with significant difference between any two groups (F = 47.73, p < 0.05). The primary clinical success rates were 80% (12/15), 90% (9/10), and 92.3% (12/13) in OS,EI, and UGTI groups, respectively, with no significant difference between any two groups (χ2 = 0.34, p > 0.05). The secondary clinical success rates were 100% for all three groups. The overall complication rates of OS, EI, and UGTI groups were 20% (3/15), 10% (1/10), and 7.7% (1/13), respectively, with no significant difference between any two groups (χ2 = 1.00, p > 0.05). The infection rates were 13.3% (2/15), 10% (1/10), and 0% (0/13) in OS, EI, and UGTI groups respectively, with no significant difference between any two groups (χ2 = 1.80, p > 0.05). The reintervention rates were 6.7% (1/15), 0% (0/10), 7.7% (1/13) in OS, EI, and UGTI groups, respectively, with no significant difference between two groups (χ2 = 0.95, p > 0.05). Neuralgia was relieved in all patients.ConclusionsOS, EI, and UGTI are efficacious and safe options for the treatment of appropriate patients with traumatic and iatrogenic PAs. UGTI would be considered as a first‐line therapy for this condotion.
Laminectomy for Penetrating Spinal Cord Injury with Retained Foreign Bodies
Authors: Zhang Peng , Liu Xiaoyang , Zhou Dongsheng , Zhang Qingyu 
Published: June 2022

BackgroundPenetrating spinal cord injury (PSCI) with retained foreign bodies (RFB) is rarely observed in clinics and may result in a complete or incomplete neurological deficit. This study was performed to appraise the treatment effect of laminectomy for PSCI with RFB.Case PresentationThis study presented three patients referred to a tertiary hospital between August 2011 and October 2018 due to PSCI with RFB and receiving laminectomy. The first patient was a 25‐year‐old female with a butcher's knife piercing the T9 lamina and T10 vertebral body obliquely; the second was a 49‐year‐old male who suffered a perforating wound of the cervical spinal canal and injury of vertebral artery from foreign glass, while the third was a 60‐year‐old male with a wooden stick penetrating stomach and terminating in the L1 lamina. The first and second patients immediately underwent laminectomy for debridement and removal of RFB, while the third received two‐staged operations to remove the retained stick thoroughly. Unfortunately cases 1 and 3 eventually resulted in total paralysis and case 2 revealed no improvement in myodynamia. Then, Medline/PubMed, Embase and the Cochrane Library were systematically searched, and 23 articles involving 25 additional cases with this kind of injury were included for analysis.ConclusionsThe optimal treatment strategy for penetrating spinal cord injury with retained foreign bodies remains challenging and should be assessed case‐by‐case. If possible, surgical removal of foreign bodies by laminectomy is preferred immediately to prevent delayed presentation and persistent contamination. Meanwhile, a multidisciplinary team is needed to address concomitant injuries.
Clinical Outcomes of Culture‐Negative and Culture‐Positive Periprosthetic Joint Infection: Similar Success Rate, Different Incidence of Complications
Authors: Xu Zhiyang , Huang Changyu , Lin Yiming , Chen Yongfa , Fang Xinyu , Huang Zida , Zhang Chaofan , Zhang Zhenzhen , Zhang Wenming 
Published: June 2022

ObjectiveTo compare the clinical outcomes of culture‐negative periprosthetic joint infection (CN PJI) with those of culture‐positive periprosthetic joint infection (CP PJI).MethodsThis study retrospectively examined data from 77 patients who underwent revision surgery due to periprosthetic joint infection (PJI) after hip and knee arthroplasty at our center from January 2012 to June 2017. There were 37 males and 40 females, with an average age of 63.6 year. All patients were classified by Tsukayama type, according to the bacterial culture results of synovial fluid and pre‐ and intraoperative tissues, 24 cases were included in the CN PJI group, and 53 cases were included in the CP PJI group. All patients underwent routine blood tests, liver, renal function tests, erythrocyte sedimentation rate (ESR) and C‐reactive protein (CRP) measurements. The remission rates of CN PJI and CP PJI were compared. The effects of the culture results on the curative effect were further compared by survival analysis.ResultsThe patients were followed regularly with an average of 29.2 months (range, 12–76 months). In total, there were 24 cases of CN PJI, with an incidence of 29.63%. The overall success rate of CN PJI group was 86.4% (19/22), and overall success rate of CP PJI group was 87.5% (42/48). The relative efficacy of various surgical options was: one‐stage revision 100% (7/7), two‐stage revision 96.3% (26/27), debridement and implant retention 64.3% (9/14), respectively. There was no significant difference in the success rate between the CN PJI group and the CP PJI group. The incidence of antibiotic‐related complications for the CN PJI group was significantly higher than that of the CP PJI group, with 58.3% for CN PJI and 11.3% for CP PJI, respectively.ConclusionWhen CN PJI was treated according to the strict standards for the diagnosis and treatment, the success rate of treatment for the CN PJI group was similar to that for the CP PJI group. The incidence of antibiotic‐related complications from the CN PJI group was higher than that from the CP PJI group.
An amino acid transporter‐like protein (OsATL15) facilitates the systematic distribution of thiamethoxam in rice for controlling the brown planthopper
Authors: Xiao Yuyan , Zhang Hanlin , Li Zhiwei , Huang Tinghong , Akihiro Takashi , Xu Jian , Xu Hanhong , Lin Fei 
Published: June 2022

SummaryCharacterization and genetic engineering of plant transporters involved in the pesticide uptake and translocation facilitate pesticide relocation to the tissue where the pests feed, thus improving the bioavailability of the agrichemicals. We aimed to identify thiamethoxam (THX) transporters in rice and modify their expression for better brown planthopper (BPH) control with less pesticide application. A yeast library expressing 1385 rice transporters was screened, leading to the identification of an amino acid transporter‐like (ATL) gene, namely OsATL15, which facilitates THX uptake in both yeast cells and rice seedlings. In contrast to a decrease in THX content in osatl15 knockout mutants, ectopic expression of OsATL15 under the control of the CaMV 35S promoter or a vascular‐bundle‐specific promoter gdcsPpro significantly increased THX accumulation in rice plants, thus further enhancing the THX efficacy against BPH. OsATL15 was localized in rice cell membrane and abundant in the root transverse sections, vascular bundles of leaf blade, and stem longitudinal sections, but not in hull and brown rice at filling stages. Our study shows that OsATL15 plays an essential role in THX uptake and its systemic distribution in rice. OsATL15 could be valuable in achieving precise pest control by biotechnology approaches.
Facial cleft presenting as a congenital facial papule
Authors: Gao Julia L. , Rogers Gary F. , Myseros John S. , Habeshian Kaiane A. 
Published: June 2022

AbstractTessier number 3 craniofacial clefts are a rare congenital deformity of the oronasoocular region with variable severity, most often with serious impacts on appearance and function due to involvement of the bone and soft tissue. However, they can occasionally manifest mildly as a skin‐colored congenital facial papule present with subtle anatomic anomalies and signs of deeper involvement, such as crusting and oozing. Recognizing that a congenital facial papule, including non‐midline lesions, may be the presenting sign of an underlying developmental anomaly is important to avoid missing the diagnosis of a more extensive underlying congenital defect. We present a rare case of a forme fruste variant of a Tessier number 3 craniofacial cleft to raise awareness of its presentation and advise initial management in hopes of improving outcomes.
Six‐rowed wild‐growing barleys are hybrids of diverse origins
Authors: Guo Yu , Himmelbach Axel , Weiss Ehud , Stein Nils , Mascher Martin 
Published: June 2022

SUMMARYCrop–wild gene flow is common when domesticated plants and their wild relatives grow close to each other. The resultant hybrid forms appear as semi‐domesticates and were sometimes considered as missing links between crops and their wild progenitors. Wild‐growing barleys in Central and Eastern Asia, named Hordeum agriocrithon, show hallmark characters of both wild and domesticated forms. Their spikes disintegrate at maturity to disperse without human intervention, but bear lateral grains, which were favored by early farmers and are absent from other wild barleys. As an intermediate form, H. agriocrithon has been proposed several times as a progenitor of domesticated barley. Here, we used genome‐wide marker data and whole‐genome resequencing to show that all H. agriocrithon accessions of a major germplasm collection are hybrid forms that arose multiple times by admixture of diverse domesticated and wild populations. Although H. agriocrithon barleys have not played a special role in barley domestication, future analysis of the adaptative potential of bi‐directional crop–wild gene flow in extant barleys may prove a fertile research field.
De novo centromere formation in pericentromeric region of rice chromosome 8
Authors: Xue Chao , Liu Guanqing , Sun Shang , Liu Xiaoyu , Guo Rui , Cheng Zhukuan , Yu Hengxiu , Gu Minghong , Liu Kai , Zhou Yong , Zhang Tao , Gong Zhiyun 
Published: June 2022

SUMMARYNeocentromeres develop when kinetochores assemble de novo at DNA loci that are not previously associated with CenH3 nucleosomes, and can rescue rearranged chromosomes that have lost a functional centromere. The molecular mechanisms associated with neocentromere formation in plants have been elusive. Here, we developed a Xian (indica) rice line with poor growth performance in the field due to approximately 272 kb deletion that spans centromeric DNA sequences, including the centromeric satellite repeat CentO, in the centromere of chromosome 8 (Cen8). The CENH3‐binding domains were expanded downstream of the original CentO position in Cen8, which revealed a de novo centromere formation in rice. The neocentromere formation avoids chromosomal regions containing functional genes. Meanwhile, canonical histone H3 was replaced by CENH3 in the regions with low CENH3 levels, and the CenH3 nucleosomes in these regions became more periodic. In addition, we identified active genes in the deleted centromeric region, which are essential for chloroplast growth and development. In summary, our results provide valuable insights into neocentromere formation and show that functional genes exist in the centromeric regions of plant chromosomes.