bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive analysis of ZFPM2-AS1 prognostic value, immune microenvironment, drug sensitivity, and co-expression network: from gastric adenocarcinoma to pan-cancers
Authors: Chen Di , Wang Mengmeng , Jiang Xin , Xiong Zhifan 
Published: April 2022

Abstract
Background
ZFPM2-AS1, as an oncogenic lncRNA, plays an essential role in the progression of several tumors. However, the prognostic significance, biological function, and molecular mechanism of ZFPM2-AS1 in most tumors have not been fully elucidated.

Methods
We analyzed differentially expressed immune-related lncRNAs (IRlncRNAs) and clustered gastric adenocarcinoma (GAC) samples based on these lncRNAs expression. Then, WGCNA and survival analysis were performed to determine key IRlncRNA (ZFPM2-AS1) in GAC. The comprehensive analysis was performed to evaluate the association between ZFPM2-AS1 expression and survival, tumor microenvironment (TME), immune-related factors, and related signal pathways in pan-cancers. Furthermore, we constructed a co-expression network of ZFPM2-AS1, and NUP107 and C8orf76 were identified as target mRNAs. We further evaluated the role of NUP107 and C8orf76 in the GAC microenvironment. More importantly, real-time polymerase chain reaction (qRT-PCR) was employed to validate ZFPM2-AS1, NUP107 and C8orf76 expression.

Results
ZFPM2-AS1 was remarkably overexpressed and correlated with poor overall survival in most tumors. Further analysis showed that ZFPM2-AS1 was related to various immune cells infiltrated in the microenvironment of most tumors. GSEA revealed that ZFPM2-AS1 in GAC was primarily involved in immune-related pathways. Furthermore, NUP107 and C8orf76 were identified as potential target mRNAs of ZFPM2-AS1, which was related to infiltrating immune cells in the GAC microenvironment. qRT-PCR verified that ZFPM2-AS, NUP107 and C8orf76 were highly expressed in gastric cancer cells.

Conclusion
ZFPM2-AS1 could be a potential biomarker for cancer prognosis, and a promising immune target for cancer therapy. Furthermore, ZFPM2-AS1 might play an immunosuppressive role in the GAC microenvironment.
Trials by video link after the pandemic: the pros and cons of the expansion of virtual justice
Authors: de Vocht D. L. F. 
Published: April 2022

AbstractThe Covid-19 pandemic has led to an enormous increase in the use of technology in the courtroom. This development raises the important question on the potential effects of the digitalisation of criminal justice—especially from the viewpoint of the right to a fair trial. This contribution discusses this complicated question from different angles. It focuses on a number of different assumptions underlying the debate: the assumption that the use of technology in the courtroom diminishes human interaction, impedes an effective defence, influences decision-making and affects the legitimacy of the trial. This is done with the aim to shed light on the lack of evidentiary basis of these assumptions which clearly complicates the current discussion on the future of technology in the courtroom. The author argues that the validity of these assumptions needs to be adequately tested before we can make any long-term decisions on the content and scope of virtual criminal justice.
Emotions and Digital Well-Being: on Social Media’s Emotional Affordances
Authors: Steinert Steffen , Dennis Matthew James 
Published: April 2022

Abstract
Social media technologies (SMTs) are routinely identified as a strong and pervasive threat to digital well-being (DWB). Extended screen time sessions, chronic distractions via notifications, and fragmented workflows have all been blamed on how these technologies ruthlessly undermine our ability to exercise quintessential human faculties. One reason SMTs can do this is because they powerfully affect our emotions. Nevertheless, (1) how social media technology affects our emotional life and (2) how these emotions relate to our digital well-being remain unexplored. Remedying this is important because ethical insights into (1) and (2) open the possibility of designing for social media technologies in ways that actively reinforce our digital well-being. In this article, we examine the way social media technologies facilitate online emotions because of emotional affordances. This has important implications for evaluating the ethical implications of today’s social media platforms, as well as for how we design future ones.
Quantitative detection of locomotive wheel polygonization under non-stationary conditions by adaptive chirp mode decomposition
Authors: Chen Shiqian , Wang Kaiyun , Zhou Ziwei , Yang Yunfan , Chen Zaigang , Zhai Wanming 
Published: April 2022

AbstractWheel polygonal wear is a common and severe defect, which seriously threatens the running safety and reliability of a railway vehicle especially a locomotive. Due to non-stationary running conditions (e.g., traction and braking) of the locomotive, the passing frequencies of a polygonal wheel will exhibit time-varying behaviors, which makes it too difficult to effectively detect the wheel defect. Moreover, most existing methods only achieve qualitative fault diagnosis and they cannot accurately identify defect levels. To address these issues, this paper reports a novel quantitative method for fault detection of wheel polygonization under non-stationary conditions based on a recently proposed adaptive chirp mode decomposition (ACMD) approach. Firstly, a coarse-to-fine method based on the time–frequency ridge detection and ACMD is developed to accurately estimate a time-varying gear meshing frequency and thus obtain a wheel rotating frequency from a vibration acceleration signal of a motor. After the rotating frequency is obtained, signal resampling and order analysis techniques are applied to an acceleration signal of an axle box to identify harmonic orders related to polygonal wear. Finally, the ACMD is combined with an inertial algorithm to estimate polygonal wear amplitudes. Not only a dynamics simulation but a field test was carried out to show that the proposed method can effectively detect both harmonic orders and their amplitudes of the wheel polygonization under non-stationary conditions.
High-Density Nanowells Formation in Ultrafast Laser-Irradiated Thin Film Metallic Glass
Authors: Prudent Mathilde , Iabbaden Djafar , Bourquard Florent , Reynaud Stéphanie , Lefkir Yaya , Borroto Alejandro , Pierson Jean-François , Garrelie Florence , Colombier Jean-Philippe 
Published: April 2022

AbstractWe present an effective approach for fabricating nanowell arrays in a one-step laser process with promising applications for the storage and detection of chemical or biological elements. Biocompatible thin films of metallic glasses are manufactured with a selected composition of Zr65Cu35, known to exhibit remarkable mechanical properties and glass forming ability. Dense nanowell arrays spontaneously form in the ultrafast laser irradiation spot with dimensions down to 20 nm. The flared shape observed by transmission electron microscopy is ideal to ensure chemical or biological material immobilization into the nanowells. This also indicates that the localization of the cavitation-induced nanopores can be tuned by the density and size of the initial nanometric interstice from the columnar structure of films deposited by magnetron sputtering. In addition to the topographic functionalization, the laser-irradiated amorphous material exhibits structural changes analyzed by spectroscopic techniques at the nanoscale such as energy-dispersive X-ray spectroscopy and electron energy loss spectroscopy. Results reveal structural changes consisting of nanocrystals of monoclinic zirconia that grow within the amorphous matrix. The mechanism is driven by local oxidation process catalyzed by extreme temperature and pressure conditions estimated by an atomistic simulation of the laser-induced nanowell formation.
Length-length, Length–weight, and Weight-weight Relationships of Yellowfin (Thunnus Albacares) and Bigeye (Thunnus Obesus) Tuna Collected From the Commercial Handlines Fisheries in the South China Sea
Authors: Nguyen Khanh Quoc , Phan Huyen Trong , Tran Phu Duc , Van Nguyen Binh , Van Do Thanh , Nguyen Luong Trong , Van To Phuong , Vu Nghiep Ke 
Published: April 2022

AbstractTuna fisheries have become the most important contributor to the coastal central provinces of Vietnam since it was introduced in early 1990s. However, developing effective management guidelines for yellowfin (Thunnus albacares) and bigeye (Thunnus obesus) tuna, the main target species for longline and handline fisheries, is difficult because there is no information on its growth characteristics. In particular, length-length, length–weight, and weight-weight relationships, the important components of fisheries production models, do not exist for those species. This study first provided those relationship equations and represented an improvement in the knowledge of these species in its distribution range with maximum sizes updated.
Real world data and data science in medical research: present and future
Authors: Togo Kanae , Yonemoto Naohiro 
Published: April 2022

AbstractReal world data (RWD) are generating greater interest in recent times despite being not new. There are various purposes of the RWD analytics in medical research as follows: effectiveness and safety of medical treatment, epidemiology such as incidence and prevalence of disease, burden of disease, quality of life and activity of daily living, medical costs, etc. The RWD research in medicine is a mixture of digital transformation, statistics or data science, public health, and regulatory science. Most of the articles describing the RWD or real-world evidence (RWE) in medical research cover only a portion of these specializations, which might lead to an incomplete understanding of the RWD. This article summarizes the overview and challenges of the RWD analysis in medical fields from methodological perspectives. As the first step for the RWD analysis, data source of the RWD should be comprehended. The progress of the RWD is closely related to the digitization, especially of medical administrative data and medical records. Second, the selection of appropriate statistical and epidemiological methods is highly critical for an RWD analysis than those for randomized clinical trials. This is because it contains greater varieties of bias, which should be controlled by balancing the underlying risk between treatment groups. Last, the future of the RWD is discussed in terms of overcoming limited data by proxy confounders, using unstructured text data, linking of multiple databases, using the RWD or RWE for a regulatory purpose, and evaluating values and new aspects in medical research brought by the RWD.
Experimental and Numerical Study of Energy Dissipation Components of a New Metallic Damper Device
Authors: Zlatkov Dragan , Ristić Danilo , Zorić Andrija , Ristić Jelena , Mladenović Biljana , Petrović Žarko , Trajković-Milenković Marina 
Published: April 2022

Abstract
Purpose
The novel metallic damper device for passive vibration control of structures, which is designed primarily for seismic protection of buildings, is described in this paper. It consists of the base plate, fixed into foundation, with two concentric cycles of vertical components and a middle steel activating plate anchored to the isolated structure. During an earthquake, the middle steel activating plate moves together with main structure causing bending of vertical components. Seismic energy is absorbed due to plastic deformation of the vertical components of the damper. The performance of various vertical components, the key elements of the novel damper is studied in this paper. The advantages of this type of damper reflect in its ability to adapt its own features depending on the intensity of the earthquake and that it has equivalent characteristics in every horizontal direction due to rotational symmetry.

Methods
Sixteen experimental tests of the vertical components of the damper, were conducted to obtain their hysteretic behaviour. Numerical models using the finite element method and the Abaqus/Standard software were developed, validated and verified with experimentally obtained results.

Results
The experimental results show significant energy absorption of the vertical components of the novel damper. Numerical models can be used in further research instead of expensive experimental tests.

Conclusions
The vertical components of the novel damper possess extraordinary hysteretic performance. If the components of the energy dissipation device are properly designed for maximum displacements, the device is not expected to suffer heavy damage or total failure during earthquakes.
DeepVaR: a framework for portfolio risk assessment leveraging probabilistic deep neural networks
Authors: Fatouros Georgios , Makridis Georgios , Kotios Dimitrios , Soldatos John , Filippakis Michael , Kyriazis Dimosthenis 
Published: April 2022

AbstractDetermining and minimizing risk exposure pose one of the biggest challenges in the financial industry as an environment with multiple factors that affect (non-)identified risks and the corresponding decisions. Various estimation metrics are utilized towards robust and efficient risk management frameworks, with the most prevalent among them being the Value at Risk (VaR). VaR is a valuable risk-assessment approach, which offers traders, investors, and financial institutions information regarding risk estimations and potential investment insights. VaR has been adopted by the financial industry for decades, but the generated predictions lack efficiency in times of economic turmoil such as the 2008 global financial crisis and the COVID-19 pandemic, which in turn affects the respective decisions. To address this challenge, a variety of well-established variations of VaR models are exploited by the financial community, including data-driven and data analytics models. In this context, this paper introduces a probabilistic deep learning approach, leveraging time-series forecasting techniques with high potential of monitoring the risk of a given portfolio in a quite efficient way. The proposed approach has been evaluated and compared to the most prominent methods of VaR calculation, yielding promising results for VaR 99% for forex-based portfolios.
Histoire sociale de l’Europe et tournant global: Une rencontre tardive
Authors: Drayton Richard 
Published: April 2022

Histoire sociale de l’Europe et tournant global Une rencontre tardivePourquoi l’histoire européenne a-t-elle pris si tard le tournant global ? Si le passé de l’Europe s’est bien sûr toujours construit par rapport à ses périphéries islamiques ou mongoles, et plus tard par rapport à ses colonies, ce n’est que récemment que l’on a compris que l’histoire européenne et extra-européenne s’entremêlent dans une relation dynamique d’influences réciproques. L’histoire intellectuelle et économique l’a reconnu avant l’histoire sociale qui, dans son épanouissement à partir des années 1960, tenait pour acquis que les formes sociales européennes étaient à la fois plus avancées et catégoriquement différentes des autres. Dans les années 1970 et 1980 cependant, une génération après la décolonisation politique, de nouveaux travaux ont commencé à explorer l’influence des périphéries sur le noyau européen et à évaluer l’Europe de l’extérieur. Depuis le début du xxie siècle, on assiste à l’émergence d’une histoire sociale européenne globalisée. En sortant des contraintes du paradigme national, elle ouvre la voie à de nouveaux projets et méthodes historiques pan- et transeuropéens. Ceux-ci suscitent de nouvelles questions sur la façon dont nous pourrions reconfigurer l’histoire européenne de manière à comprendre l’Europe centrale et orientale selon leurs propres termes plutôt que comme de simples extensions retardées de phénomènes européens occidentaux « avancés ».
Déglobaliser l’histoire globale de l’Europe
Authors: Sawyer Stephen W. 
Published: April 2022

Déglobaliser l’histoire globale de l’EuropeCet article soutient que les récentes histoires globales de l’Europe ne représentent qu’un mode très spécifique de conscience globale dans l’historiographie et les sciences sociales européennes. S’il ne fait aucun doute que notre compréhension du passé européen serait plus que desservie par un isolationnisme malvenu ou le simple rejet des considérables gains scientifiques de l’histoire globale, les récents changements dans les structures, les technologies et les modes de la mondialisation héritée de l’après-guerre froide nous poussent à reconsidérer la manière dont cette interconnexion globale s’est effectivement réalisée à d’autres époques et en particulier au xixe siècle. L’histoire européenne après notre plus récent « tournant global » doit tenir compte des modes antérieurs de conscience globale et examiner comment la mondialisation elle-même s’est en retour vue façonnée par cette connaissance. En effet, la compréhension passée de l’interconnexion mondiale n’a pas nécessairement favorisé l’ouverture des frontières, une interdépendance ou une fluidité culturelle croissantes. Ainsi, en réponse aux forces mondiales perçues, des modes d’organisation sociale de désintégration et de réduction d’échelle émergèrent et se consolidèrent. On a également pu assister à des tentatives de canalisation des bénéfices de ces processus mondiaux à la suite de la prise de conscience de leurs retombées potentiellement enrichissantes et déstabilisantes. Ces efforts de contrôle de la mondialisation ne l’ont pas empêchée, mais lui ont donné une forme spécifique à des moments particuliers. À titre d’exemple, l’article soutient que le demi-siècle qui a suivi la Révolution française a été le témoin de ce que l’on pourrait appeler une globalisation déglobalisante, soit un moment où l’intégration mondiale, que beaucoup considéraient comme responsable du bouleversement de la Révolution, ne s’est certainement pas arrêtée, mais s’est vue réorientée au service d’une nation souveraine par la naissance de nouveaux modes d’écriture des sciences sociales et de l’histoire.
Globaliser l’Europe
Authors: Motadel David 
Published: April 2022

Globaliser l’EuropeCet essai propose une réflexion sur l’étude historique des liens entre l’Europe moderne et contemporaine et le reste du monde. Il explore les manières dont l’histoire européenne peut être intégrée à l’histoire globale, en considérant l’Europe non seulement comme un moteur, mais aussi comme un produit des transformations mondiales. À partir d’un large aperçu historiographique, l’auteur discute de l’influence du « tournant global » sur différents domaines de l’histoire européenne moderne et contemporaine, notamment l’histoire politique, économique, sociale, intellectuelle et environnementale. Il soutient que l’histoire globale représente tant un défi qu’une opportunité considérable pour les européistes d’ouvrir l’histoire européenne moderne. Cette approche nous aidera finalement à remodeler notre compréhension des frontières de l’Europe – et du domaine de l’histoire européenne lui-même. En d’autres termes, cela nous permettra de déprovincialiser l’Europe. De manière plus générale, l’essai aborde également des questions plus larges sur les continents (et d’autres unités spatiales) en tant que catégories ontologiques dans les études historiques.
La Maison des esclaves de Goree : à l’intersection entre histoire, mémoires et émotions
Authors: Sene Cheikh 
Published: April 2022

RésuméGorée est un symbole et un lieu de mémoire de la traite atlantique et de l’esclavage en Sénégambie. Le 27 décembre 1996, le journaliste français Emmanuel de Roux a publié dans le quotidien Le Monde un article intitulé « Le mythe de la maison des esclaves résiste à la réalité ». Cet article mettait en cause la Maison des esclaves de Gorée qui, selon l’auteur, n’avait jamais hébergé d’esclaves issus de la traite négrière. L’article a donné lieu à un débat public mêlant histoire, mémoire et émotions. En 1997, des chercheurs et les autorités politiques sénégalaises ont organisé une rencontre scientifique pour contrer toute « tentative d’endormissement de la mémoire collective ».
Limitations of econometric evaluation of nonrandomized residential energy efficiency programs: A case study of Northern California rebate programs
Authors: Sherwin Evan D. , Meyer Russell M. , Azevedo Inês M.L. 
Published: April 2022

Abstract
Residential energy efficiency programs play an important role in combating climate change. More precise quantification of the magnitude and timing of energy savings would bring large system benefits, allowing closer integration of energy efficiency into resource adequacy planning and balancing variable renewable electricity. However, it is often difficult to quantify the efficacy of an energy efficiency intervention, because doing so requires consideration of a hypothetical counterfactual case in which there was no intervention, and randomized control trials are often implausible. Although quasi-experimental econometric evaluation sometimes works well, we find that for a set of energy efficiency rebate programs in Northern California, a naïve interpretation of econometric measurement finds that rebate participation is associated with an average increase in electricity consumption of 7.2% [4.5%, 10.1%], varying in magnitude and sign depending on the type of appliance or service covered by the rebate. A subsequent household survey on appliance purchasing behavior and analysis of utility customer outreach data suggest that this regression approach is likely measuring the gross impact of buying a new appliance but fails to adequately capture a counterfactual comparison. Indeed, it is unclear whether it is even possible to construct a suitable counterfactual for econometric analyses of these rebate programs using data generally available to electric utilities. We view these results as an illustration of a limitation of econometric methods of program evaluation and the importance of weighing engineering modeling and other imperfect methods against one another when attempting to provide useful evaluations of real-world policy interventions.
ALTERNATING CIRCULAR SUMS OF BINOMIAL COEFFICIENTS
Authors: CHU WENCHANG 
Published: April 2022

AbstractBy combining the generating function approach with the Lagrange expansion formula, we evaluate, in closed form, two multiple alternating sums of binomial coefficients, which can be regarded as alternating counterparts of the circular sum evaluation discovered by Carlitz [‘The characteristic polynomial of a certain matrix of binomial coefficients’,Fibonacci Quart.3(2) (1965), 81–89].