bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the health and sociodemographic characteristics of people seeking advice with claiming Universal Credit: A longitudinal analysis of UK Citizens Advice data, 2017-2021
Authors: Brown Heather , Xiang Huasheng , Cheetham Mandy , Morris Steph , Gibson Marcia , Katikireddi Srinivasa Vittal , Munford Luke Aaron , Taylor-Robinson David , Finney Hannah , Bartle Victoria , Baxter Andrew J , Whickham Sophie , Craig Peter , Bambra Clare 
Published: August 2022

Abstract
Background
The UK Department for Work and Pensions (DWP) administers Universal Credit (UC) – the main UK benefit for people in- and out-of-work. UC is being rolled out nationally from 2013 to 2024. Citizens Advice (CA) is an independent charity that provides advice and support to people making a claim for UC. The aim of this study is to understand who is seeking advice from CA when making a UC claim and how the types of people seeking advice are changing as the rollout of UC continues.
Methods
Co-developed with Citizens Advice Newcastle and Citizens Advice Northumberland we performed longitudinal analysis of national data from Citizens Advice for England and Wales on the health (mental health and limiting long term conditions) and socio-demographic of 1,003,411 observations for people seeking advice with claiming UC over four financial years (2017/18 to 2020/21). We summarised population characteristics and estimated the differences between the four financial years using population-weighted t-tests. Findings were discussed with three people with lived experience of seeking advice to claim UC to help frame our interpretation and policy recommendations.
Results
When comparing 2017/18 to 2018/19, there was a significantly higher proportion of people with limiting long term conditions seeking advice with claiming UC than those without (+ 2.40%, 95%CI: 1.31%-3.50%). However as the rollout continued between 2018/29 and 2019/20 (-6.75%, 95%CI: -9.62%--3.88%) and between 2019/20 and 2020/21 (-2.09%, 95%CI: -2.54%--1.64%), there were significantly higher proportions of those without a limiting long term condition seeking advice than with. When comparing 2018/19 to 2019/20 and 2019/20 to 2020/21, there was a significant increase in the proportion of self-employed compared to unemployed people seeking advice with claiming UC (5.64%, 95%CI: 3.79%-7.49%) and (2.26%, 95%CI: 1.29%-3.23%) respectively.
Conclusion
As the rollout for UC continues, it is important to understand how changes in eligibility for UC may impact on those who need help with applying for UC. Ensuring that the advice process and application process is responsive to a range of people with different needs can help to reduce the likelihood that the process of claiming UC will exacerbate health inequalities.
Observation of metallic mosaic phase in 1T-TaS2 at equilibrium
Authors: Salzmann Björn , Hujala Elina , Witteveen Catherine , Hildebrand Baptiste , Berger Helmuth , von Rohr Fabian , Nicholson C. W. , Monney Claude 
Published: August 2022

Abstract
The transition-metal dichalcogenide tantalum disulphide (1T-TaS2) hosts a commensurate charge density wave (CCDW) at temperatures below 165 K where it also becomes insulating.
The low temperature CCDW phase can be driven into a metastable "mosaic" phase by means of either laser or voltage pulses which shows a large density of CDW domain walls as well as a closing of the electronic band gap.
The exact origins of this pulse-induced metallic mosaic are not yet fully understood.
Here, we observe the occurrence of such a metallic mosaic phase on the surface of TaS2 without prior pulse excitation using scanning tunnelling microscopy and spectroscopy (STM/STS) over continuous areas larger than 100x100 nm2 and macroscopic areas on the millimetre scale.
We attribute the appearance of the mosaic phase to the presence of surface defects which arrange into the characteristic dense domain wall network.
Based on our STM measurements, we further argue how the appearance of the metallic behaviour in the mosaic phase can be explained by local stacking differences of the top two layers induced by the large number of domain walls.
Thus, we provide a potential avenue to explain the origin of the pulse induced mosaic.
Docking and simulation Studies on CDK4 for targeting Cell cycle Arrest in Cancer using Flavanone and its Congener
Authors: Nagare sagar , Lokhande Kiran Bharat , Swamy K. Venkateswara 
Published: August 2022

Abstract
Flavanone compounds are naturally occurring phytochemicals present in most of citrus fruits reported to be a potential anticancer moiety as it majorly participates in inhibition of cell cycle, apoptosis, and Angiogenesis. Because of poor bioavailability Natural Flavanones were not used as therapeutic targets so flavanone congeners was prepared by Modifying at B-functional group using compound libraries such as Drugbank, PubChem, Sellkchem Database .Cyclin dependent Kinase is primarily activating cell cycle and potentiating M phase, in order to control cell cycle in cancer Cyclin dependent pathway was targeted and potential CDK4 Receptor protein was retrieved from Protein Data Bank (PDBID:2W9Z).Binding site was determined using FlexX docking. Flavanone and its congeners were docked against 2W9Z receptor Protein with docking software FlexX. For validation of docking results Molecular Dynamics simulations of the best fitting molecule were carried out using Desmond Package. Noncovalent interactions like hydrogen bond, electrostatic interaction, and Vander walls potentials for stable conformations were calculated. Thus upon docking and molecular dynamics studies we discovered the potential flavanone derivatives such as Flavanone 20, flavanone 23,and flavanone 29 will become a potential drug target in controlling cell cycle arrest and may become a futuristic candidate in targeting cancer
Are lipids always light? Lipids in larval lampreys are enriched in 13C but depleted in 2H relative to muscle
Authors: Evans Thomas , Beharie Shale 
Published: August 2022

Abstract

Stable isotope ratios in organisms can be used to estimate source contributions to the organism. However, during lipid synthesis light isotopes of carbon (12C) and hydrogen (1H) are preferentially incorporated into the lipids, potentially causing source contributions to be poorly estimated. Contrary to expectations and other published examples in animals, larval lampreys, which are basal vertebrates, have lipids which are enriched in heavy isotopes of carbon (13C), but still depleted in heavy hydrogen (deuterium;2H). Four lamprey species were collected and their isotopes ratios of δ2H, δ13C, δ15N were measured in their muscle before and after lipid extraction. Larval lamprey of one species was collected every three months for a year from two streams in Maryland and the isotope ratios of muscle before and after lipid extraction, as well as the extracted lipid were measured. Muscle δ13C was positively related to C:N ratios in samples when lipids were not removed and δ2H was negatively associated with the percent hydrogen in a sample. As expected, the measured difference between muscle and lipid δ2H (ΔMLδ2H) was the same for all months and was 111‰ (SE = ± 21, n = 35), but the ΔMLδ13C was different between months (ANOVA, F3,53= 5.05, p < 0.005) and was always negative. Our work suggests that while lipids are often enriched in12C relative to muscle, this is not a universal rule. The physiological mechanism(s) for generating heavy carbon-backbones in lipids remains unknown and requires exploration.
Consumer perception of brand equity based on environmental sustainability in the Amazon: development and validation of a scale
Authors: Diego Luiz , Holanda Francisco Sandro Rodrigues 
Published: August 2022

Abstract
PurposeBrands gradually became the core dimension and strategic asset of branding for organizations of all sizes, and today many companies adopt various forms of green marketing activities as part of their strategies. The objective of this study was to investigate and develop the psychometric properties of precision and validity of a scale for brand evaluation equity based on the environmental sustainability of the Brazilian Amazon.Design/methodologyThe scale was validated by adopting the standards described in the Standards for Educational and Psychological Testing APA. As samples for validation tests, eight companies were selected for among the ones who develop their business model in the Brazilian Amazon region. The data were applied to 262 potential consumers.Findings A scale with 22 items was constructed and validated, and after evaluation by the specialists, 22 items were obtained, divided into four dimensions: Brand quality perception — BQP (6 questions); Strategic Brand Positioning – SBP (10 questions); Willingness to purchase — WtB (3 questions) and Innovation in retail — INM (3 questions). Three items were modified because they presented the CVC at 0.8 and were accepted after the adjustments. The instrument items showed good internal consistency (0.877) regarding their domains. For DIF data, the scale invariably works for older and younger people for almost all items, except item INM 04.Research limitations/implicationsThis article fills the gap in the literature by developing a scale to assess consumer perception of brand equity and environmental sustainability. However, the findings are limited to the variation in the data collection. Considering the period of COVID-19 pandemic, most participants chose to fill in the scale online. Thus, the scale data are limited by the context in which the research was applied.Practical implicationsThe development and subsequent validation of the contextualized psychometric scale fills an important gap in the academic literature, providing a better understanding of the perception of potential consumers about the sustainable brand equity that generalist scales could not measure. Likewise, the scale provides essential information for brand entrepreneurs who aim to develop their products in a sustainable way, an important tool for managers to test and validate the extent to which new advertising materials demonstrate brand authenticity.Originality/ValueThe present study contributes to the directional and effective branding of brands related to environmental sustainability, mainly from tropical forests such as the Amazon rainforest. Furthermore, the findings suggest that the developed and validated cross-culturally instrument can be applied to potential consumers aged between 19 and 64 years of both sexes.
The effect of human disturbance on the community composition and diversity of aquatic plants in the tropical wetlands of Lake Tana, Ethiopia
Authors: Kahsay Abrehet , Stiers Iris , Wondie Ayalew , Triest Ludwig , Meester Luc , Kibret Mulugeta , Verleyen Elie , Adgo Enyew , Lemmens Pieter 
Published: August 2022

Abstract
The aquatic plants in wetlands have been threatened by increasing human disturbances in recent decades. The present study investigates to what extent human disturbance affects the community composition and richness of aquatic plants in 3 different wetland types in Lake Tana, Ethiopia. We selected twelve wetlands representing 3 different wetland types (four lacustrine, four river mouth, and four riverine papyrus wetlands) and collected data on aquatic plant species richness and community composition, major local environmental variables, and the degree of human disturbance at multiple plots along three transects in each wetland during the dry and wet season of 2018. The unique and shared contributions of human disturbance, local environmental variables, and wetland type on variations in community compositions of aquatic plants in wetlands were investigated using variation partitioning analyses. The Overlap and Decreasing Fill (NODF) metric was used to estimate the nestedness in aquatic plant communities. A total of 113 aquatic plant species, belonging to 38 families, were identified across all wetlands during the dry and wet season. Wetland types explained the greatest proportion of variation in community composition, followed by human disturbance and local environmental variables. The species richness was negatively correlated with the overall degree of human disturbance, while NODF was positively correlated. Irrespective of the degree of human disturbance, papyrus swamps had systematically the highest species richness and supported clearly different plant communities, therefore conservation efforts should focus on these habitats. In addition, measures should be taken to restore the highly disturbed and species-poor river mouth wetlands.
Short S-Glass fibre reinforced polymer composites: design, manufacture and tribological performance on the influence of fibre length and concentration
Authors: Raju Raju , Loy Chee Wah , Cho Kiho , Farrar Paul , Prusty B. Gangadhara 
Published: August 2022

Abstract
Fibre-reinforced biocomposites usage has gained prominence over the past decade. Although higher fracture toughness was observed when fibres were added to biocomposites, material degradation could occur due to filler and fibre content intolerance in the biocomposite matrix. Optimisation of resin-fibre-filler ratios helps in increasing the tribological performance of high load-bearing applications. However, the tribological performance is less understood due to limited in-vitro studies on the effect of fibre microstructures. A comprehensive investigation of the reciprocating and rotary wear behaviour of different compositions was carried out by varying fibre (0%, 5%, 10% and 15%) to particulate filler (40%, 45%, 50%, and 55%) weight fractions. The investigation aimed to identify the optimal composition of fibre-reinforced biocomposites based on the in-vitro ball-on-disc reciprocating and rotary wear tests in the presence of modified Fusayama solution. The cross-sectional areas of wear tracks were analysed using laser microscopy and scanning electron microscopy techniques to assess the surface morphology and subsurface damage of the wear tracks on biocomposites and the antagonist. The numerical results were statistically analysed using two-way ANOVA followed by a posthoc Tukey’s test (p = 0.05). The results showed a combination of adhesive, abrasive and fatigue wear for all the tested Groups. The friction coefficient had a longer transient period for the 5 wt% and 10 wt% Groups. Based on the surface roughness, coefficient of friction, SEMs, specific wear rate, and ease of manufacturing, the threshold limit for fibre loading was found to be 10 wt%. The rotary test had a considerably lower specific wear rate compared to the reciprocating test. Fibre weight fraction was found to be the influencing factor of the abrasive wear behaviour compared to fibre length for the tested Groups.
In Situ and Ex Situ Conservation Gap Analyses of West African Priority Crop Wild Relative
Authors: Nduche Michael Ugochukwu , Brehm Joana Magos , Maxted Nigel , Parra-Quijano Mauricio 
Published: August 2022

Abstract
Crop wild relatives are genetically related wild taxa of crops with unique resources for crop improvement through the transfer of novel and profitable genes. The in situ and ex situ conservation gap analyses for priority crop wild relatives from West Africa were evaluated using species distribution modelling, ecogeographic diversity, and complementary analyses. A total of 20, 125 unique occurrence records were used for the conservation gap analysis, however, 26 taxa had no occurrence data. 64 taxa (62.7%) occurred in protected areas, 56 taxa (55%) were conserved ex situ, while 76.7% (43) of the accessions are underrepresented with less than 50 accessions conserved ex situ. Areas of highest potential diversity were found in the Woroba and Montangnes districts in Cote d’Ivoire, Nzerekore, Faranah, Kindia, and Boke regions of Guinea, South-South, and North-East zones of Nigeria, and Kono and Koinadugu districts in Sierra Leone. Hotspots were found in Atlantique, Littoral, Mono, Kouffo, Atakora, Donga, and Colline provinces of Benin, Accra, and Volta regions of Ghana, North – Central Nigeria, and Lacs district of Cote d’Ivoire and Nzerekore region of Guinea. 29 reserve sites for active in situ conservation were identified, 11 occur in protected areas, while 18 are located outside protected areas. The establishment of the reserve sites will complement existing PAs and ensure long-term active in situ and ex situ conservation and sustainable utilization of priority CWR to underpin food security and mitigate climate change in the region.
Robust and Rigorous Identification of Tissue-Specific Genes by Statistically Extending Tau Score
Authors: Lüleci Hatice Büşra , Yılmaz Alper 
Published: August 2022

Abstract
Introduction: Tissue-specific genes are a class of genes whose functions and expressions are preferred in one or several tissues, restrictedly. Identification of tissue-specific genes is essential for discovery of multi-cellular biological processes such as tissue-specific molecular regulations, tissue development, physiology and also pathogenesis of tissue-associated diseases. In this study, we aimed to identify tissue-specific genes for various human tissues/organs in more robust and rigorous fashion.
Method: Gene expression data, derived from five large RNA sequencing(RNA-seq) projects, spanning 96 different human tissues was retrieved fromArrayExpress and ExpressionAtlas. The first step is categorization of genes using significant filters and tau score as specificity index. After calculation of tau for each gene in all datasets separately, statistical distance from maximum expression level was estimated using a new meaningful procedure. Specific expression of agene in one or several tissues was calculated after integration of tau and statistical distance estimation that is called as extended tau approach. Obtainedtissue-specific genes for 96 different human tissues were functionally annotated and some comparison were carried out to show effectiveness of extended taumethod.
Results: Categorization of genes based on expression level and identification of tissue-specific genes for a large number of tissues/organs were executed. Genes were successfully assigned to multiple tissues by generating extended tau approach as opposed to original tau score which can assign tissue specificity to single tissue only.
Keywords: Tissue-specific genes, RNA-Seq, Tau score
“Before I was like a Tarzan. But now, I take a pause”: Mixed methods feasibility study of the Naungan Kasih parenting program to prevent violence against children in Malaysia
Authors: Lachman Jamie M , Juhari Rumaya , Stuer Francesca , Zinser Paula , Han Qing , Gardner Frances , McCoy Amalee , Yaacob Siti Nor Binti , Kahar Rojanah Binti , Mansor Mariani Binti , Madon Zainal Bin , Arshat Zarinah Binti , Nadzri Farah Zeehan Binti Mohd , Aftar Nur Farhana Ardillah , Landers Cassie 
Published: August 2022

Abstract
Background: Despite impressive strides in health, social protection, and education, children continue to experience high rates of child maltreatment in Malaysia. This mixed-methods study assessed the feasibility of a five-session, social learning-based parenting program delivered by government staff in a community setting to reduce violence against children. Methods: Parents of children ages 0-17 were recruited from two communities near Kuala Lumpur to participate in the government-run program called the Naungan Kasih Positive Parenting Program (“Protecting through Love” in Bahasa Melayu). Quantitative data from female caregivers (N = 74) and children ages 10-17 (N = 26) were collected along with qualitative interviews and focus groups with parents, children, and facilitators. The primary outcome was child maltreatment with secondary outcomes including neglect, positive parenting, acceptability of corporal punishment, harsh parenting, positive discipline, and child behavior problems. Multilevel Poisson regression and multilevel linear regression were conducted to compare baseline and post-test outcomes. Qualitative interviews and focus groups examined how participants experienced the program utilizing a thematic analysis approach. Results: Quantitative analyses found per-post reductions in overall child maltreatment, physical abuse, emotional abuse, attitudes supporting corporal punishment, parent sense of inefficacy, and child behavior problems. There were no reported effects on positive and harsh parenting, parental mental health, and marital satisfaction, nor were there any other significant effects reported by children. ]Qualitative findings suggested that the program had tangible benefits for female caregivers involved in the program, with the benefits extending to their family members.Conclusions: This feasibility study is one of the few studies in Southeast Asia that examined the feasibility and initial program effects of a parenting program delivered by government staff to families with children across the developmental spectrum from ages 0 to 17 years. Promising results suggest that the program may be effective at reducing child maltreatment across a range of child ages. Findings also indicate areas for program improvement prior to further delivery and testing, including additional training and content on sexual reproductive health, parenting children with disabilities, and online child protection.
WITHDRAWN: Global metabolic changes by Bacillus cyclic lipopeptide extracts on stress responses of para rubber leaf
Authors: Tunsagool Paiboon , Kruaweangmol Pongsakorn , Sunpapao Anurag , Kuyyogsuy Arnannit , Jaresitthikunchai Janthima , Roytrakul Sittiruk , Vongsangnak Wanwipa 
Published: August 2022

Abstract
The changing environmental conditions generate the abiotic stress like exposing of chemicals and biotic stress like Phytophthora palmivora infection which is causes leaf fall disease affecting the growth rate of para rubber seedlings resulting in economic loss. To prevent abiotic and biotic stresses, biocontrol agents like cyclic lipopeptides (CLPs) from Bacillus spp. have been introduced to reduce the usage of chemically synthesized fungicides and fertilizers. This study aimed to use Bacillus CLP extracts as a biological agent to stimulate the plant growth system in para rubber seedlings comparing with an exogenous plant hormone (salicylic acid; SA) using untargeted metabolomics. CLP extracts were obtained from B. subtilis PTKU12 and exogenous SA that were each applied on the leaves of para rubber seedlings. The expressed metabolic network responding to stress induced by exposing of different agents was analyzed using liquid chromatography-tandem mass spectrometry. There were 1,702 and 979 metabolites which were detected in positive and negative ion modes of electrospray ionization, respectively. The application of CLP extracts showed the greatest accumulation of up-regulated metabolite changes in the leaves belonging to 56 metabolic pathways. The analysis of metabolic pathways indicated that CLP extracts played an important role in alanine, aspartate and glutamate metabolism to stress response leading to plant growth promotion. These findings revealed the effect of Bacillus CLP extracts on plant growth promotion considering as a protective option for para rubber plantation.