bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoparticle Optical Sensor Arrays: Gas Sensing and Biomedical Diagnosis
Authors: Lu Xiaohui , Suslick Kenneth S. , Li Zheng 
Published: September 2022

AbstractChemical sensor arrays provide a simple but powerful means of creating detection specificity through pattern recognition of the responses from an array of highly cross‐reactive sensor elements. Optically responsive nanoparticles have emerged as a useful class of chemical sensors and enabled the development of real‐time, sensitive, cost‐effective and portable microdetectors for targeting biochemical analytes of interest. The unique and fascinating physicochemical properties of nanoparticles play a key role in building promising array‐based sensing platforms. This perspective will describe the principles, fabrication, and applications of various nanoparticle‐based optical sensor arrays. Choice of nanomaterials, optical signal transduction, array substrate and fabrication, as well as statistical data analyses will be elaborately discussed. As two major areas of applications, the detection of environmentally related volatiles and clinical use for biomedical diagnosis will be discussed in detail. Finally, the remaining challenges and future perspectives within this analytical topic will be highlighted.
Characteristics of homologous recombination repair pathway genes mutation in ovarian cancers
Authors: Yi Zongbi , Chen Min , Sun Shaoxing , Yang Chunxu , Mei Zijie , Yang Hui , Xiang Qingming , Qiu Hui 
Published: September 2022

AbstractBackgroundFew studies have investigated the characteristics of non‐BRCA homologous recombination repair (HRR) pathway somatic mutations, and the impact of these mutations on efficacy of treatment in ovarian cancer patients is not clear. Therefore, we conducted this study to analyze the frequency and spectrum of somatic mutations in HRR pathway genes in patients with ovarian cancer and to examine the relationships between somatic mutations in HRR pathway genes and their effects on the efficacy of platinum‐based chemotherapy.MethodsWe performed targeted sequencing of 688 genes related to the occurrence, development, treatment, and prognosis of solid tumors. Somatic mutations were identified by paired analysis of tumor tissue and germline DNA in blood cells.ResultsA total of 38 patients with ovarian cancer were included in the study, and 35 (92.1%) patients were diagnosed with high‐grade serous carcinoma. All patients exhibited somatic mutations in the tumor tissue samples. The commonly mutated genes were TP53 (73.7%), BRCA2 (55.3%), NF1 (52.6%), BRCA1 (47.4%), and CDH1 (47.4%). Overall, 71.1% of the patients exhibited mutation in at least one HRR pathway gene. The most frequently altered HRR genes were BRCA2 (55.3%), followed by BRCA1 (47.4%), ATM (44.7%), BARD1 (42.1%), and CHEK1 (36.8%). The median progression‐free survival (PFS) in patients with HRR pathway mutation was 36.0 months compared with 13.6 months in patients with no HRR pathway mutation (hazard ratio [HR], 0.25; 95% confidence interval [CI], 0.08–0.77; p = 0.016). Patients harboring BRCA1/2 and/or CDK12 mutations displayed a longer PFS (median, 36.0 months) compared with patients with no BRCA1/2 or CDK12 mutation (median, 13.6 months; HR, 0.21; 95% CI, 0.07–0.61; p = 0.004). In multivariate analysis Cox proportional hazards models, after adjustment for tumor stage at diagnosis and histology of initial diagnosis, patients with HRR pathway mutation had a longer PFS than patients with HRR wild‐type genes (p = 0.006).ConclusionsHRR pathway somatic mutations are common in Chinese patients with ovarian cancer. HRR pathway somatic mutations were associated with improved sensitivity to platinum‐based chemotherapy. Large‐scale prospective studies are needed to verify our findings.
Design of Unsteady‐State Fixed‐Bed Processes for Heat Regeneration, Ad‐/Desorption, and Gas‐Solid Reactions
Authors: Kern Christoph , Jess Andreas 
Published: September 2022

AbstractThis review covers all three unsteady‐state fixed‐bed processes important in chemical engineering, namely, heat transfer from a hot gas to a cold fixed bed (heat regenerator), ad‐ and desorption of a gas for a Langmuir and a linear isotherm, and regeneration of a coked catalyst by coke burn‐off as an important example of a transient gas‐solid process. Albeit of inherent differences, the processes have strong analogies. For example, a moving heat or mass transfer zone, spreading or with constant pattern behavior, is formed. For each case, numerical and suitable analytical solutions for process design either selected from literature or developed in this work are derived and compared. Experimental data, if available, are also considered.
ALK‐rearranged Mesenchymal Neoplasms: A Report of 9 cases Further Expanding the Clinicopathologic Spectrum of Emerging Kinase Fusion Positive Group of Tumors
Authors: Dermawan Josephine K. , DiNapoli Sara E. , Mullaney Kerry A. , Sukhadia Purvil , Agaram Narasimhan P. , Dickson Brendan C. , Antonescu Cristina R. 
Published: September 2022

AbstractAnaplastic lymphoma kinase (ALK) fusions are oncogenic drivers in diverse cancer types. Although well established in inflammatory myofibroblastic tumor (IMT) and epithelioid fibrous histiocytoma (EFH), ALK rearrangements also occur in the emerging family of kinase fusion‐positive mesenchymal neoplasms. We investigated 9 ALK‐rearranged mesenchymal neoplasms (exclusive of IMT and EFH) arising in 6 males and 3 females with a wide age range of 10 to 78 years old (median 42 years). Tumors involved superficial and deep soft tissue (6) and viscera (3). Three were myxoid or collagenous low‐grade paucicellular tumors with haphazardly arranged spindled cells. Three were cellular tumors with spindled cells in intersecting short fascicles or solid sheets. Three cases consisted of uniform epithelioid cells arranged in nests or solid sheets, with prominent mitotic activity and necrosis. Band‐like stromal hyalinization was present in 6 cases. All tumors expressed ALK; four were positive for S100 and five were positive for CD34, while all were negative for SOX10. By targeted RNA sequencing, the breakpoints involved ALK exon 20; the 5′ partners included KLC1, EML4, DCTN1, PLEKHH2, TIMP3, HMBOX1, and FMR1. All but two patients presented with localized disease. One patient had distant lung metastases; another had diffuse pleural involvement. Of the six cases with treatment information, five were surgically excised [one also received neoadjuvant radiation therapy (RT)], and one received RT and an ALK inhibitor. Of the four patients with follow‐up (median 5.5 months), one remained alive with stable disease and three were alive without disease. We expand the clinicopathologic spectrum of ALK‐fused mesenchymal neoplasms, including a low‐grade malignant peripheral nerve sheath tumor‐like subset and another subset characterized by epithelioid and high‐grade morphology.
The effect of virtual reality therapy and counseling on students' public speaking anxiety
Authors: Sarpourian Fatemeh , Samad‐Soltani Taha , Moulaei Khadijeh , Bahaadinbeigy Kambiz 
Published: September 2022

AbstractBackground and AimsOne of the barriers to effective communication between speaker and listeners is public speaking anxiety (PSA). Over recent years, PSA has become common among students as the most widespread social anxiety (SA). Virtual reality (VR) and counseling therapy help reduce PSA. Therefore, the present study aimed to investigate the effect of VR therapy and counseling on students' PSA and SA.MethodsThis quasi‐experimental study was conducted on 30 students at three levels of undergraduate, postgraduate, and PhD at Kerman University of Medical Sciences and Shiraz University of Medical Sciences (15 students in the intervention group and 15 in the control group). The intervention group observed four virtual classroom scenarios in a 30‐min session, and the control group attended a 90‐min group counseling session. Data were collected using by Personal Report of Public Speaking Anxiety, Liebowitz Social Anxiety Scale, and Igroup Presence Questionnaire. The data analysis was done using SPSS version 21. Descriptive analysis (frequency and percentage, mean, standard deviation, and quartiles) and analytical tests (paired t‐test and independent t‐test) were used to analyze the data.ResultsThe results showed that VR and counseling did not affect SA scores and statistical differences before and after the intervention were not statistically significant. However, VR and counseling reduced PSA. The mean of IPQ/IGP (physical presence) was 63.73. The participants' SA means (93.76) were higher than the mean PSA (73.4).ConclusionsVR and counseling did not affect students' SA, but they reduced PSA. If the intervention duration in future studies are longer, the effect of VR and counseling on reducing SA is likely to become more apparent.
Season and reproductive activity influence cortisol levels in the Malagasy primate Lepilemur edwardsi
Authors: Bethge Janina , Fietz Joanna , Razafimampiandra Jean Claude , Ruthsatz Katharina , Dausmann Kathrin H. 
Published: September 2022

AbstractThroughout the year, wild animals are exposed to a variety of challenges such as changing environmental conditions and reproductive activity. These challenges may affect their stress hormone levels for varying durations and in varying intensities and impacts. Measurements of the glucocorticoid hormone cortisol in the hair of mammals are considered a good biomarker for measuring physiological stress and are increasingly used to evaluate stress hormone levels of wild animals. Here, we examined the influence of season, reproductive activity, sex, as well as body condition on hair cortisol concentrations (HCC) in Lepilemur edwardsi, a small Malagasy primate species. L. edwardsi lives in the seasonal dry forests of western Madagascar, which are characterized by a strongly changing resource availability throughout the year. We hypothesized that these seasonal changes of resource availability and additionally the reproductive cycle of this species would influence HCC of L. edwardsi. Results revealed that hair cortisol concentration of females did not change seasonally or with the reproductive cycle. However, we found a significant increase of hair cortisol levels in males from the early wet season during the early dry season (mating season). This increase is presumably due to changed behavior during the mating season, as sportive lemurs travel more and show aggressive behavior during this time of the year. This behavior is energy‐costly and stressful, and presumably leads to elevated HCC. As elevated cortisol levels may impair immune function, L. edwardsi males might also be more susceptible to parasites and diseases, which is unfavorable in particular during a period of low resource availability (dry season).
HOW UNDERSTANDING YOUR ROLE(S) HELPS WITH MAKING DIFFICULT DECISIONS
Authors: Pliner Eric 
Published: September 2022

AbstractThe author contends that the terms “job” and “role” are often used interchangeably, but these “are not simple synonyms. While a job consists of one or more tasks for which its holder accepts responsibility, a role goes further to encompass the broader context.” He discusses the recent ramifications of the term “stakeholder,” and how it has profound effects about how organizations are operated. This includes the Business Roundtable “Statement on the Purpose of a Corporation” in 2019. In considering your roles and role responsibilities, he asks questions such as “To whom you are obligated?” and “whose interests must you represent?” For understanding your core social identity, “How would you describe yourself to someone who didn’t know you?” and “What categories, communities, groups, social classes, do you see yourself as a part of?” In considering your role, some questions include “Are we part of the same social identity group?” and “Do your decisions reflect the integrity of what you have told or shown me about who you are?” Pliner concludes that “developing a deep understanding of your roles in all their complexity will help you to better align to – or frame misalignment with – your moral code and ethical context.”
Reliability prediction used dynamic Bayesian networks for redundant system with time‐lag correlation
Authors: Liu Kaixin , Zhou Zhen , Qi Jia , Sun Yongquan , Guo Kangkang 
Published: September 2022

AbstractIn the reliability prediction process of a redundant system, active units and standby units are assumed independent generally. Due to the interaction among units, failure of the active unit gives the standby unit a potential interior shock, then the standby unit fails after a period of operation. Therefore, the correlation between the active unit and the standby unit is triggered by the failure of the active unit and also has time‐lag. In this paper, a correlation estimated method with two parameters is proposed based on cross‐correlation analysis, where the two parameters are time‐lag interval and time‐lag correlation coefficient, the discriminant conditions of independent, simultaneous correlation and time‐lag correlation are given. Subsequently, the Conditional Probability Table (CPT) of Dynamic Bayesian Network (DBN) is updated by adding time‐lag intervals and time‐lag correlation coefficients. Then, DBN is optimized into Time‐lag Dynamic Bayesian Network (TDBN). Meanwhile, the modeling process and calculated method of TDBN are given. To reduce the complexity of TDBN, the maximum time‐lag correlation coefficient and the time‐lag interval corresponding are regarded as the main parameters to estimate time‐lag correlation. Finally, through the simulation analysis and the case of Chinese train control system (CTCS‐3), it could be seen that the reliability prediction of TDBN is more accurate than DBN, TDBN improves the reliability prediction accuracy of train and driver interface module to 0.8135 either.
Structural Adjustments of Zn(II)‐Terpyridine Analogues by Pendent of Coligand: Solvothermal Syntheses, Crystal Structure, and Photophysical Behavior
Authors: Wang Ying‐Yi , Cheng Fang‐Ge , Lv Wen‐Jian , Ding Bo , Liu Zheng‐Yu , Wang Xiu‐Guang , Yang En‐Cui 
Published: September 2022

AbstractTwo 2,6‐bis(2‐pyrazin‐2‐yl)‐4‐(4‐(tetrazol‐5‐yl)phenyl)pyridine (HL1)‐based transition metal complexes, {[Zn(L1)(L2)0.5]⋅H2O}n (1) and [Zn3(H2O)2(L1)2(L3)]n (2, H2L2=2,5‐dihydroxyterephthalic acid, and H4L3=pyromellitic acid) have been solvothermally synthesized by varying the substitutes appended on phenyl‐based dicarboxylate coligands. The tetragonal pyramidal ZnII ions in 1 are periodically extended by two deprotonated L1− and one L22− connectors, resulting in the first L1−‐derived three‐fold interpenetrating wrinkle layer. By contrast, the C2‐symmetric {Zn3(COO)2} clusters in 2 are periodically bridged by centrosymmetric L34− and bulky L1− connectors, leading to a four‐connected diamond framework. Apparently, the replacement of two hydroxyl groups by a carboxylate pair in the coligands has significantly achieved the manipulations on both the motif and dimensionality of the terpyridine‐derived metal complexes. Furthermore, the both samples exhibit strong thermal stability and efficient L1−‐dominated light‐responsive ability.
Is the Nicolai map unique?
Authors: Lechtenfeld Olaf , Rupprecht Maximilian 
Published: September 2022

Abstract
The Nicolai map is a field transformation that relates supersymmetric theories at finite couplings g with the free theory at g = 0. It is obtained via an ordered exponential of the coupling flow operator integrated from 0 to g. Allowing multiple couplings, we find that the map in general depends on the chosen integration contour in coupling space. This induces a large functional freedom in the construction of the Nicolai map, which cancels in all correlator computations. Under a certain condition on the coupling flow operator the ambiguity disappears, and the power-series expansion for the map collapses to a linear function in the coupling. A special role is played by topological (theta) couplings, which do not affect perturbative correlation functions but also alter the Nicolai map. We demonstate that for certain ‘magical’ theta values the uniqueness condition holds, providing an exact map polynomial in the fields and independent of the integration contour. This feature is related to critical points of the Nicolai map and the existence of ‘instantons’. As a toy model, we work with $$ \mathcal{N} $$
N
= 1 supersymmetric quantum mechanics. For a cubic superpotential and a theta term, we explicitly compute the one-, two- and three-point correlation function to one-loop order employing a graphical representation of the (inverse) Nicolai map in terms of tree diagrams, confirming the cancellation of theta dependence. Comparison of Nicolai and conventional Feynman perturbation theory nontrivially yields complete agreement, but only after adding all (1PI and 1PR) contributions.
Self-exciting price impact via negative resilience in stochastic order books
Authors: Ackermann Julia , Kruse Thomas , Urusov Mikhail 
Published: September 2022

AbstractMost of the existing literature on optimal trade execution in limit order book models assumes that resilience is positive. But negative resilience also has a natural interpretation, as it models self-exciting behaviour of the price impact, where trading activities of the large investor stimulate other market participants to trade in the same direction. In the paper we discuss several new qualitative effects on optimal trade execution that arise when we allow resilience to take negative values. We do this in a framework where both market depth and resilience are stochastic processes.
One-off events? An empirical study of hackathon code creation and reuse
Authors: Mahmoud Ahmed Samir Imam , Dey Tapajit , Nolte Alexander , Mockus Audris , Herbsleb James D. 
Published: September 2022

AbstractContextHackathons have become popular events for teams to collaborate on projects and develop software prototypes. Most existing research focuses on activities during an event with limited attention to the evolution of the hackathon code.ObjectiveWe aim to understand the evolution of code used in and created during hackathon events, with a particular focus on the code blobs, specifically, how frequently hackathon teams reuse pre-existing code, how much new code they develop, if that code gets reused afterwards, and what factors affect reuse.MethodWe collected information about 22,183 hackathon projects from Devpost and obtained related code blobs, authors, project characteristics, original author, code creation time, language, and size information from World of Code. We tracked the reuse of code blobs by identifying all commits containing blobs created during hackathons and identifying all projects that contain those commits. We also conducted a series of surveys in order to gain a deeper understanding of hackathon code evolution that we sent out to hackathon participants whose code was reused, whose code was not reused, and developers who reused some hackathon code.Result9.14% of the code blobs in hackathon repositories and 8% of the lines of code (LOC) are created during hackathons and around a third of the hackathon code gets reused in other projects by both blob count and LOC. The number of associated technologies and the number of participants in hackathons increase reuse probability.ConclusionThe results of our study demonstrates hackathons are not always “one-off” events as the common knowledge dictates and it can serve as a starting point for further studies in this area.
Developing research questions in conversation with the literature: operationalization & tool support
Authors: Díaz Oscar , Contell Jeremías P. 
Published: September 2022

AbstractEmpirical Software Engineering rests on the understanding of practical problems and their solution counterparts. Frequently, solutions are not absolute but relative to the context where the problem is observed. This tends to imply that the solution and the problem unveil gradually together, and hence, researchers are not always in the position to state the research question (RQ) at the onset. Like software engineers when facing blurred requirements, researchers might not be familiar enough with the problem in the early phases of a research to properly scope their RQs (hereafter referred to as RQ Scoping). Here, the literature may play the role of the stakeholders in Agile methods: keeping the focus on the aspects that are essential (vs. accidental) of the RQ. Informed by Inductive Top-Down Theorizing, this article acknowledges RQ Scoping as iterative and incremental, entailing a conversation between the experimental work and literature reviewing. Yet, for literature reviewing to become “Agile” it is not only required to be driven by the RQ but also to have tool support. Tools might bring transparency and traceability, both factors especially welcome in a scenario characterized by testing (is my RQ relevant?) and adjustment (how can I make my RQ relevant?). Specifically, the advent of the RQ in close relationship with the literature advises for “Agile” literature reviewing to be conducted at the place where the literature is naturally kept: the Reference Management System (e.g., Mendeley). This article introduces the theoretical underpinnings, design principles, proof of concept and evaluation for FRAMEndeley, a Mendeley-integrated utility for RQ Scoping.
Lipoprotein(a) levels and risk of adverse events after myocardial infarction in patients with and without diabetes
Authors: Silverio Angelo , Cancro Francesco Paolo , Di Maio Marco , Bellino Michele , Esposito Luca , Centore Mario , Carrizzo Albino , Di Pietro Paola , Borrelli Anna , De Luca Giuseppe , Vecchione Carmine , Galasso Gennaro 
Published: September 2022

AbstractIntroduction: The aim of this study was to evaluate the association of lipoprotein(a) [Lp(a)] levels with long-term outcome in patients with recent history of myocardial infarction (MI), and to investigate if diabetes may influence this association.Methods: Consecutive MI patients who underwent urgent/emergent coronary angiography from February 2013 to June 2019 were prospectively collected. The primary outcome was the composite of MI recurrence and all-cause death. The propensity score weighting technique was used to account for covariates potentially influencing the relationship between Lp(a) levels and the study outcomes.Results: The study population consisted of 1018 post-MI patients (median age 63 years). Diabetes was reported in 280 patients (27.5%), who showed lower Lp(a) levels than patients without diabetes (p = 0.026). At a median follow-up of 1121 days, the primary outcome was reported in 182 patients (17.9%). At univariable Cox regression analysis, Lp(a) was associated with the risk of the primary outcome in the overall population and in non-diabetic patients, but not in diabetics. The adjusted Cox regression analysis confirmed the independent association between Lp(a) values and the primary outcome in non-diabetic patients, but not in diabetics.Lp(a) levels > 70 mg/dL were independently associated with the risk of the primary outcome in non-diabetic patients (adjusted HR: 2.839; 95% CI, 1.382–5.832), but not in diabetics.Conclusions: In this real-world post-MI population, increasing Lp(a) levels were significantly associated with the risk of recurrent MI and all-cause death, and very high Lp(a) serum concentration independently predicted long-term outcome in non-diabetic patients, but not in diabetics.