bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Derived Sequence of a Pre-Jaffard Family
Authors: Spirito Dario 
Published: May 2022

AbstractWe introduce the concept of pre-Jaffard family, a generalization of Jaffard families obtained by substituting the locally finite hypothesis with a much weaker compactness hypothesis. From any such family, we construct a sequence of overrings of the starting domain that allows to decompose stable semistar operations and singular length functions in more cases than what is allowed by Jaffard families. We also apply the concept to one-dimensional domains, unifying the treatment of sharp and dull degree of a Prüfer domain.
Randomizing without randomness
Authors: Ghirardato Paolo , Pennesi Daniele 
Published: May 2022

AbstractWe provide a methodology for eliciting utility midpoints from preferences, assuming that payoffs are consumption plans and that preferences satisfy a minimal form of additive separability. The methodology does not require any subjective or objective uncertainty. Thus, this construction of utility midpoints allows us to define mixtures of acts in a purely subjective fashion, without making any assumptions as to the decision maker’s reaction to the uncertainty that may be present. This approach makes it possible to provide a simple and fully subjective characterization of the second-order subjective expected utility model, allowing a clear distinction of such model from subjective expected utility.
LY450139 Inhibited Ti-Particle-Induced Bone Dissolution via Suppressing Notch and NF-κB Signaling Pathways
Authors: Gao Jijian , Wu Peng , Chi Yingjun , Xu Hongyu , Zhao Yong , Song Nanyan , Mao Yuanqing 
Published: May 2022

AbstractAseptic loosening of the prosthesis caused by wear-particle-induced osteolysis is a long-term complication and one of the most common reasons for the failure of joint implants. The primary cause of aseptic loosening of the prosthesis is overactive bone resorption caused by wear-particle-activated osteoclasts in both direct and indirect ways. Therefore, drugs that can inhibit differentiation and bone resorption of osteoclasts need investigation as a potential therapeutic strategy to prevent and treat peri-prosthetic osteolysis and thereby prolong the service life of the prosthesis. This study has verified the potential inhibitory effect of LY450139 on inflammatory osteolysis induced by titanium particles in a mice skull model. In addition, we found that LY450139 inhibited receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis, bone resorption, and podosomal actin belt formation in a dose-dependent manner without evidence of cytotoxicity in vitro. In addition, LY450139 significantly decreased the expression of osteoclast-specific markers, including TRAP, CTSK, V-ATPase d2, CTR, DC-STAMP, NFATc1, and the downstream target gene Hes1 in Notch signaling pathway. Further investigation of the molecular mechanism demonstrated that LY450139 inhibited the formation of osteoclasts via inhibition of the NF-κB and Notch signaling pathways. In summary, LY450139 inhibited the formation of RANKL-mediated osteoclasts via NF-κB and Notch signaling and inhibited Ti particle-induced inflammatory osteolysis in vivo. LY450139 is a potential targeted drug for the treatment of peri-prosthetic osteolysis and other osteolytic disease associated with overactive osteoclasts.
Characterisation of carapace composition in developing and adult ostracods (Skogsbergia lerneri) and its potential for biomaterials
Authors: Rumney Benjamin M. , Morgan Siân R. , Mosselmans J. Frederick W. , Malik F. Tegwen , Holden Simon J. , Parker Andrew R. , White Nick , Lewis Philip N. , Albon Julie , Meek Keith M. 
Published: May 2022

AbstractThe protective carapace of Skogsbergia lerneri, a marine ostracod, is scratch-resistant and transparent. The compositional and structural organisation of the carapace that underlies these properties is unknown. In this study, we aimed to quantify and determine the distribution of chemical elements and chitin within the carapace of adult ostracods, as well as at different stages of ostracod development, to gain insight into its composition. Elemental analyses included X-ray absorption near-edge structure, X-ray fluorescence and X-ray diffraction. Nonlinear microscopy and spectral imaging were performed to determine chitin distribution within the carapace. High levels of calcium (20.3%) and substantial levels of magnesium (1.89%) were identified throughout development. Amorphous calcium carbonate (ACC) was detected in carapaces of all developmental stages, with the polymorph, aragonite, identified in A-1 and adult carapaces. Novel chitin-derived second harmonic generation signals (430/5 nm) were detected. Quantification of relative chitin content within the developing and adult carapaces identified negligible differences in chitin content between developmental stages and adult carapaces, except for the lower chitin contribution in A-2 (66.8 ± 7.6%) compared to A-5 (85.5 ± 10%) (p = 0.03). Skogsbergia lerneri carapace calcium carbonate composition was distinct to other myodocopid ostracods. These calcium polymorphs and ACC are described in other biological transparent materials, and with the consistent chitin distribution throughout S. lerneri development, may imply a biological adaptation to preserve carapace physical properties. Realisation of S. lerneri carapace synthesis and structural organisation will enable exploitation to manufacture biomaterials and biomimetics with huge potential in industrial and military applications.
Decoding the dopamine transporter imaging for the differential diagnosis of parkinsonism using deep learning
Authors: Zhao Yu , Wu Ping , Wu Jianjun , Brendel Matthias , Lu Jiaying , Ge Jingjie , Tang Chunmeng , Hong Jimin , Xu Qian , Liu Fengtao , Sun Yimin , Ju Zizhao , Lin Huamei , Guan Yihui , Bassetti Claudio , Schwaiger Markus , Huang Sung-Cheng , Rominger Axel , Wang Jian , Zuo Chuantao , Shi Kuangyu 
Published: May 2022

Abstract

Purpose

This work attempts to decode the discriminative information in dopamine transporter (DAT) imaging using deep learning for the differential diagnosis of parkinsonism.

Methods
This study involved 1017 subjects who underwent DAT PET imaging ([11C]CFT) including 43 healthy subjects and 974 parkinsonian patients with idiopathic Parkinson’s disease (IPD), multiple system atrophy (MSA) or progressive supranuclear palsy (PSP). We developed a 3D deep convolutional neural network to learn distinguishable DAT features for the differential diagnosis of parkinsonism. A full-gradient saliency map approach was employed to investigate the functional basis related to the decision mechanism of the network. Furthermore, deep-learning-guided radiomics features and quantitative analysis were compared with their conventional counterparts to further interpret the performance of deep learning.

Results
The proposed network achieved area under the curve of 0.953 (sensitivity 87.7%, specificity 93.2%), 0.948 (sensitivity 93.7%, specificity 97.5%), and 0.900 (sensitivity 81.5%, specificity 93.7%) in the cross-validation, together with sensitivity of 90.7%, 84.1%, 78.6% and specificity of 88.4%, 97.5% 93.3% in the blind test for the differential diagnosis of IPD, MSA and PSP, respectively. The saliency map demonstrated the most contributed areas determining the diagnosis located at parkinsonism-related regions, e.g., putamen, caudate and midbrain. The deep-learning-guided binding ratios showed significant differences among IPD, MSA and PSP groups (P < 0.001), while the conventional putamen and caudate binding ratios had no significant difference between IPD and MSA (P = 0.24 and P = 0.30). Furthermore, compared to conventional radiomics features, there existed average above 78.1% more deep-learning-guided radiomics features that had significant differences among IPD, MSA and PSP.

Conclusion
This study suggested the developed deep neural network can decode in-depth information from DAT and showed potential to assist the differential diagnosis of parkinsonism. The functional regions supporting the diagnosis decision were generally consistent with known parkinsonian pathology but provided more specific guidance for feature selection and quantitative analysis.
Analysis of malingered psychological symptoms in a clinical sample for early detection in initial interviews
Authors: Barbosa-Torres Carlos , Bueso-Izquierdo Natalia , Cubo-Delgado Sixto 
Published: May 2022

AbstractMalingering consists of the production of false physical or psychological symptoms motivated by external incentives that are normally reproduced in pathologies that are not related to organic origin or there are no laboratory tests for their diagnosis, as is the case of mixed anxiety–depressive disorder and fibromyalgia syndrome. The objective of this research consisted of comparing the profile of simulative patients with fibromyalgia and mixed anxiety–depressive disorder to obtain a profile and facilitate its detection in initial interviews. The research was carried out with 78 patients (42 patients with fibromyalgia and 36 patients with mixed anxiety–depressive disorder) who were administered the professional's structured clinical judgment, the Beck Depression Inventory, the State-Trait Anxiety Questionnaire, and the Structured Symptom Simulation Inventory. The main obtained results show that the simulation classification proposed by the questionnaire is in the range of 66.67–80% with regard to coinciding with the judgment of experts, and people with suspicion of simulation of both groups of patients present similar characteristics. The simulators thus present incongruous responses in relation to the questionnaires, and high levels of trait anxiety, state, and depression predict the simulation of symptoms.
Patient-Reported Outcomes After Swallowing (SWOARs)-Sparing IMRT in Head and Neck Cancers: Primary Results from a Prospective Study Endorsed by the Head and Neck Study Group (HNSG) of the Italian Association of Radiotherapy and Clinical Oncology (AIRO)
Authors: Ursino Stefano , Calistri Elisa , De Felice Francesca , Bonomo Pierluigi , Desideri Isacco , Franco Pierfrancesco , Arcadipane Francesca , Colosimo Caterina , Mazzola Rosario , Maddalo Marta , Gonnelli Alessandra , Malfatti Giulia , Morganti Riccardo , Musio Daniela , Paiar Fabiola 
Published: May 2022

Abstract
Objectives
To prospectively investigate changes in M.D. Anderson Dysphagia Inventory (MDADI) scores in patients affected by naso- and oropharynx cancer after definitive radiochemotherapy (ChemoRT) using swallowing organs at risk (SWOARs)-sparing IMRT.

Methods
MDADI questionnaires were collected at baseline and at 6 and 12 months after treatment. MDADI scores were categorized as follows: ≥ 80 “optimal,” 80–60 “adequate,” < 60 “poor” deglutition-related quality of life (QoL) group, and dichotomized as “optimal” vs “adequate/poor” for the analysis. A mean MDADI composite (MDADI-C) change of 10 points was considered as minimal clinically important difference (MCID).

Results
Sixty-three patients were enrolled of which 47 were considered for the analysis. At baseline, 26 (55%) were “optimal” and 21 (45%) were “adequate/poor.” The mean baseline MDADI-C score was 93.6 dropping to 81 at 6 months (p = 0.013) and slightly rising to 85.5 at 12 months (p = 0.321) for the “optimal” group. Indeed, the mean baseline MDADI-C score was 64.3 rising to 77.5 at 6 months (p = 0.006) and stabilizing at 76 at 12 months (p = 0.999) for the “adequate/poor” group. A statistically significant but not clinically relevant worsening of the MDADI-C score was reported for the “optimal” group, whereas both a statistically significant and clinically meaningful improvement of the MDADI-C score were reported for the “adequate/poor” group from before to post-treatment.

Conclusion
Our results suggest a doubly clinical benefit of dose optimization to SWOARs to minimize the RT sequalae in patients with a baseline “optimal” deglutition-related QoL and to recover from cancer dysphagia in those with a baseline “adequate/poor” deglutition-related QoL.
Geochemistry of granitoids from the Austroalpine Seckau Complex: a key for revealing the pre-Alpine evolution of the Eastern Alps
Authors: Mandl Magdalena , Kurz Walter , Hauzenberger Christoph , Fritz Harald , Pfingstl Stefan 
Published: May 2022

AbstractRecent studies revealed that the calc-alkaline metagranitoids of the Seckau Complex comprise both (1) a Late Cambrian to Early Ordovician and (2) a Late Devonian to Early Carboniferous (early Variscan) intrusive complex. The older rocks of the Hochreichart Plutonic Suite reflect I to S-type affinity and are peraluminous and characterized by a general decrease in TiO2, Al2O3, MgO, CaO, P2O5, FeOt and MnO with increasing SiO2. Chondrite-normalized rare earth element (REE) plots display a slight enrichment in light rare earth elements (LREE) relative to heavy rare earth elements (HREE) as well as negative Eu anomalies ((Eu/Eu*)N = 0.15- 0.77). The whole-rock initial 87Sr/86Sr ratios calculated back to the time of emplacement (~ 496 Ma) vary between 0.7056 to 0.7061. The early Variscan rocks of the Hintertal Plutonic Suite can be subdivided into (a) the meta- to peraluminous granodioritic suite of the Pletzen Pluton and (b) the peraluminous granitic suite of the Griessstein Pluton. The Pletzen Pluton shows typical magmatic fractionation trends for most of the major oxides and trace elements plotted against SiO2. On a chondrite-normalized diagram, metagranitoids are strongly enriched in LREE and show no significant negative Eu anomaly. Metagranitoids of the Griessstein Pluton have a more peraluminous character and similar major and trace element fractionation trends compared to the Pletzen Pluton. However, the contents in SiO2, major and trace elements clearly point towards a more evolved melt with generally lower TiO2, Al2O3, MgO and CaO values and higher K2O content. Metagranitoids of the Griessstein Pluton are additionally characterized by a slight negative Eu anomaly of about 0.81 on a chondrite-normalized REE plot. Initial 87Sr/86Sr values calculated back to the time of emplacement (~ 353 Ma) of the Pletzen Pluton and the Griessstein Pluton vary between 0.7051—0.7061 and 0.7054—0.7063, respectively, and suggest the same magmatic source for both units. Application of rhyolite-MELTS modelling to the Hintertal Plutonic Suite revealed that the Griessstein Pluton formed by fractional crystallization (~ 30%) from the more primitive Pletzen Pluton. Our geochemical data from the Hochreichart Suite granitoids suggest the existence of a Late Cambrian to Early Ordovician active margin with its remnants now exposed in the Seckau Complex. The early Variscan grainitoids of the Seckau Complex are inferred as part of a magmatic arc along the southern Bohemian active continental margin that was related to the subduction of differently termed oceanic domains (Galicia-Moldanubian Ocean or Paleotethys), prior to the final collision of Gondwana and Laurussia. The general paleogeographic position of the Seckau Complex during the Variscan orogeny is considered to be south to southeast of the Bohemian Massif, adjacent to the eastern Hohe Tauern, the Schladming Tauern, and the Western Carpathians.
A systematic literature review of requirements engineering education
Authors: Daun Marian , Grubb Alicia M. , Stenkova Viktoria , Tenbergen Bastian 
Published: May 2022

AbstractRequirements engineering (RE) has established itself as a core software engineering discipline. It is well acknowledged that good RE leads to higher quality software and considerably reduces the risk of failure or budget-overspending of software development projects. It is of vital importance to train future software engineers in RE and educate future requirements engineers to adequately manage requirements in various projects. To this date, there exists no central concept of what RE education shall comprise. To lay a foundation, we report on a systematic literature review of the field and provide a systematic map describing the current state of RE education. Doing so allows us to describe how the educational landscape has changed over the last decade. Results show that only a few established author collaborations exist and that RE education research is predominantly published in venues other than the top RE research venues (i.e., in venues other than the RE conference and journal). Key trends in RE instruction of the past decade include involvement of real or realistic stakeholders, teaching predominantly elicitation as an RE activity, and increasing student factors such as motivation or communication skills. Finally, we discuss open opportunities in RE education, such as training for security requirements and supply chain risk management, as well as developing a pedagogical foundation grounded in evidence of effective instructional approaches.
Measurement Invariance of the Satisfaction with Life Scale by Sexual Orientation
Authors: Checa Irene , Di Marco Donatella , Bohórquez M. Rocío 
Published: May 2022

AbstractThe Satisfaction with Life Scale (SWLS) has shown strong evidence of reliability, validity, and gender invariance, and there is some evidence of invariance across age, culture, and educational levels. So far, invariance across sexual orientation has not been studied, despite the number of works that relate well-being to sexual orientation. The SWLS should be invariant across sexual orientation to be able to compare group means. This study aimed to explore the invariance of the SWLS across sexual orientation. A non-probabilistic sample with 553 Spanish adults (208 males, 345 females; 212 heterosexuals, 182 gays, and 138 bisexuals among other sexual orientations) participated in a survey. We tested a one-factor model using confirmatory factor analysis. We tested the configural, metric, and scalar invariance of the factorial structure of the SWLS across sexual orientation with heterosexual, lesbian/gay, and bisexual groups. According to our results, the Spanish version of the SWLS shows scalar invariance across sexual orientations, allowing a valid comparison between sexual minority and heterosexual people. Moreover, in our sample, lesbian/gay and bisexual participants obtained lower scores in life satisfaction than heterosexual participants. Bisexual people obtained the lowest score in well-being compared with the other groups. Implications related to the importance of checking instrument invariance before comparing mean differences between groups are discussed.
Limiting systemic endocrine overtreatment in postmenopausal breast cancer patients with an ultralow classification of the 70-gene signature
Authors: Opdam M. , van der Noort V. , Kleijn M. , Glas A. , Mandjes I. , Kleiterp S. , Hilbers F. S. , Kruger D. T. , Bins A. D. , de Jong P. C. , Schiphorst P. P. J. B. M. , van Dalen T. , Flameling B. , Rietbroek R. C. , Beeker A. , van den Heiligenberg S. M. , Bakker S. D. , Wymenga A. N. M. , Oving I. M. , Bijlsma R. M. , van Diest P. J. , Vermorken J. B. , van Tinteren H. , Linn S. C. 
Published: May 2022

Abstract
Purpose
Guidelines recommend endocrine treatment for estrogen receptor-positive (ER+) breast cancers for up to 10 years. Earlier data suggest that the 70-gene signature (MammaPrint) has potential to select patients that have an excellent survival without chemotherapy and limited or no tamoxifen treatment. The aim was to validate the 70-gene signature ultralow-risk classification for endocrine therapy decision making.

Methods
In the IKA trial, postmenopausal patients with non-metastatic breast cancer had been randomized between no or limited adjuvant tamoxifen treatment without receiving chemotherapy. For this secondary analysis, FFPE tumor material was obtained of ER+HER2− patients with 0–3 positive lymph nodes and tested for the 70-gene signature. Distant recurrence-free interval (DRFI) long-term follow-up data were collected. Kaplan–Meier curves were used to estimate DRFI, stratified by lymph node status, for the three predefined 70-gene signature risk groups.

Results
A reliable 70-gene signature could be obtained for 135 patients. Of the node-negative and node-positive patients, respectively, 20% and 13% had an ultralow-risk classification. No DRFI events were observed for node-negative patients with an ultralow-risk score in the first 10 years. The 10-year DRFI was 90% and 66% in the low-risk (but not ultralow) and high-risk classified node-negative patients, respectively.

Conclusion
These survival analyses indicate that the postmenopausal node-negative ER+HER2− patients with an ultralow-risk 70-gene signature score have an excellent 10-year DRFI after surgery with a median of 1 year of endocrine treatment. This is in line with published results of the STO-3-randomized clinical trial and supports the concept that it is possible to reduce the duration of endocrine treatment in selected patients.
Effectiveness of a Community-Based Crisis Resolution Team for Patients with Severe Mental Illness in Greece: A Prospective Observational Study
Authors: Koureta Aikaterini , Papageorgiou Charalabos , Asimopoulos Charis , Bismbiki Elisavet , Grigoriadou Maria , Xidia Stavroula , Papazafiri Theodora , I. Vlachos Ilias , Margariti Maria 
Published: May 2022

AbstractThis prospective observational study evaluated the effectiveness of a crisis resolution team (CRT) for outpatient treatment of psychiatric patients experiencing an acute episode of severe mental disorder. The effectiveness of the CRT (n = 65) was assessed against the care-as-usual [CAU group (n = 65)]. Patients’ clinical state, overall functioning, quality of life and satisfaction were respectively evaluated at baseline, post intervention and three-month post-intervention.CRT patients compared to the CAU group, had significantly improved outcomes concerning clinical state and patient satisfaction at post intervention phase. Statistically significant improvement was also recorded for the dimensions of environment, physical and psychological health related to quality of life. No significant differences were observed between the two groups regarding overall functioning.On the basis of these results, reforming of existing crisis-management services, in Greece, using the CRT model may improve substantially the services offered to psychiatric patients.
Size matters: contextual factors in local policy translations of National School Digitalisation Policy
Authors: Gustafsson Ulrika 
Published: May 2022

AbstractNational policies on school digitalisation take shape in their local contexts. Consequently, to understand the outcome of national policy, the local translations must be set within a contextual perspective. This article explores how four contextually different municipalities in Sweden translate national school digitalisation policy. It draws on a comparative cross-case study with data gathered from interviews, and over 150 local documents dating from 2018 to 2020. The results show how contextual aspects affects responses to national policy, and that municipalities approach school digitalisation in two distinct ways. The first, general approach, emphasises competitiveness and the creation of an enabling environment for the teachers. This is manifested in the development of special support organisations, and generous access to digital technology. The second, specific approach, emphasises local consensus in policy translations along with unity in policy adherence. Here, critique of national policy is explicit. The two approaches exemplify how translational power may be distributed differently, the former prioritising individual translational precedency for teachers over a unifying policy translation controlled through local governance. The paper suggests that contextual factors matters in the choice of approaches, one in which size matters. The paper concludes that policy makers need to acknowledge contextual dimensions within governance by weighing translational power in relation to translational coherence.