bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast self-examination and its associated factors among women who attended anti-retroviral therapy clinic in Bahir Dar city administration, North West Ethiopia
Authors: Wondie Betelhem , Aragaw Amanu , Worku Gizachew , Kassie Nigus 
Published: September 2022

Objective: Although breast self-examination has been shown to be the least-expensive, less time-consuming, and non-invasive screening method, still there is a gap in practice. Furthermore, the information among more risky population which attends anti-retroviral therapy is too limited. Therefore, the aim of this study is to assess breast self-examination practices and its associated factors among women who attended the anti-retroviral therapy clinic in Bahir Dar city administration, Northwest Ethiopia. Methods: An institution-based cross-sectional study was conducted among 660 women who attended anti-retroviral therapy clinics from March 1 to March 30, 2020. A systematic random sampling technique was used to select study participants. Pre-tested interviewer-administered questionnaires were used to collect data. Data were entered in to EPI data 3.1 and exported to Statistical Package for the Social Sciences version 23.00 software for analysis. A binary logistic regression model was fitted to identify factors associated with self-breast examination. Variables with a p value less than 0.2 in bivariable regression were candidates for multivariable regression. Adjusted odds ratios with a 95% confidence intervals and p values less than 0.05 were used to determine the association between independent and dependent variables. Hosmer–Lemeshow Test was used to determine model fitness. Result: Among 641 study participants, 224 (34.9%) have ever practiced breast self-examination. Women who attended college or above (adjusted odds ratio = 4.04, 95% confidence interval (1.65,9.90)), rich (adjusted odds ratio = 6.64, 95% confidence interval (2.72,16.20)), knowledgeable about signs and symptoms of breast cancer (adjusted odds ratio = 5.13, 95% confidence interval ( 2.55,10.31)), risk factors for breast cancer (adjusted odds ratio = 3.62, 95% confidence interval (1.85,7.07)), positive attitude toward breast self-examination (adjusted odds ratio = 2.76,95% confidence interval (1.41,11.84)), family history of breast cancer (adjusted odds ratio = 3.68,95% confidence interval (1.14,11.84)), and knowledge about breast self-examination technique (adjusted odds ratio = 2.64, 95% confidence interval (1.23,5.66)) had higher odds of breast self-examination practice. Conclusion: The practice of breast self-examination was low. During their regular visits for other issues, education and information dissemination about the benefits and techniques of self-breast examination is recommended.
A MIR17HG-derived long noncoding RNA provides an essential chromatin scaffold for protein interaction and myeloma growth
Authors: Morelli Eugenio , Fulciniti Mariateresa , Samur Mehmet K. , Ribeiro Caroline F. , Wert-Lamas Leon , Henninger Jon E. , Gullà Annamaria , Aktas-Samur Anil , Todoerti Katia , Talluri Srikanth , Park Woojun D. , Federico Cinzia , Scionti Francesca , Amodio Nicola , Bianchi Giada , Johnstone Megan , Liu Na , Gramegna Doriana , Maisano Domenico , Russo Nicola A. , Lin Charles , Tai Yu-Tzu , Neri Antonino , Chauhan Dharminder , Hideshima Teru , Shammas Masood A. , Tassone Pierfrancesco , Gryaznov Sergei , Young Richard A. , Anderson Kenneth C. , Novina Carl D. , Loda Massimo , Munshi Nikhil C. 
Published: September 2022

Abstract
Long noncoding RNAs (lncRNAs) can drive tumorigenesis and are susceptible to therapeutic intervention. Here, we used a large-scale CRISPR interference viability screen to interrogate cell-growth dependency to lncRNA genes in multiple myeloma (MM) and identified a prominent role for the miR-17-92 cluster host gene (MIR17HG). We show that an MIR17HG-derived lncRNA, named lnc-17-92, is the main mediator of cell-growth dependency acting in a microRNA- and DROSHA-independent manner. Lnc-17-92 provides a chromatin scaffold for the functional interaction between c-MYC and WDR82, thus promoting the expression of ACACA, which encodes the rate-limiting enzyme of de novo lipogenesis acetyl-coA carboxylase 1. Targeting MIR17HG pre-RNA with clinically applicable antisense molecules disrupts the transcriptional and functional activities of lnc-17-92, causing potent antitumor effects both in vitro and in vivo in 3 preclinical animal models, including a clinically relevant patient-derived xenograft NSG mouse model. This study establishes a novel oncogenic function of MIR17HG and provides potent inhibitors for translation to clinical trials.
Risk factors for aneurysm rupture among Kazakhs: findings from a national tertiary hospital
Authors: Medetov Yerkin , Babi Aisha , Makhambetov Yerbol , Menlibayeva Karashash , Bex Torekhan , Kaliyev Assylbek , Akshulakov Serik 
Published: September 2022

Abstract
Background
Rupture of intracranial aneurysms (RIA) leads to subarachnoid hemorrhage (SAH) with severe consequences. Although risks for RIA are established, the results vary between ethnic groups and were never studied in Kazakhstan. This study aimed to establish the risk factors of RIA in the Kazakh population.

Methods
Retrospective analysis of 762 patients with single IAs, who attended the neurosurgical center from 2008 until 2018, was conducted. Demographic characteristics, such as age, sex, smoking status, and hypertension were considered. Descriptive and bivariate analyses were performed. A multivariable logistic regression model was built to identify factors correlated with RIA.

Results
The mean age of participants was 48.49 ± 0.44 years old. The majority (68.37%) of IAs have ruptured. Of the ruptured aneurysms, 43.76% were < 6 mm, and 38.39% were located on the anterior cerebral and anterior communicating arteries (ACA). Logistic regression model indicates younger age group (16–40 years), smoking, having stage 3 hypertension, smaller IA size and its location on ACA increase the odds of rupture.

Conclusions
This study has revealed that younger, smoking patients with stage 3 arterial hypertension are at higher risk for RIA. Small aneurysms (< 6 mm) and location on ACA had increased odds of rupture, while larger aneurysms on internal carotid arteries had lower odds.
The experience of chronic pain among adolescents: suffering and attempt to overcome pain?
Authors: Shaygan Maryam , Jaberi Azita 
Published: September 2022

Abstract
Background
Chronic pain (CP) among adolescents has received less attention than adultsandthere is limited qualitative studies about it in Iran. This study explored the experience of CP among adolescents.

Methods
This exploratory qualitative study was conducted in April–October 2019. Participants were 14 adolescent students purposively recruited from schools in Shiraz, Iran. Semi-structured interviews were conducted for data collection and data analysis was done through conventional content analysis.

Findings
Adolescents’ experiences of CP came into nine subcategories and three main categories, namely perceived suffering, attempt to overcome pain, and attempt to find sources of support.

Conclusion
Adolescents with CP experience physical and mental suffering and attempt to manage their pain and its associated suffering through different physical and psychological strategies and using different sources of support such as family, peers, healthcare providers, and school staff.
Falls in community-dwelling women with bipolar disorder: a case–control study
Authors: Stuart Amanda L. , Pasco Julie A. , Berk Michael , Quirk Shae E. , Koivumaa-Honkanen Heli , Honkanen Risto , Mohebbi Mohammadreza , Williams Lana J. 
Published: September 2022

Abstract
Background
Falls are a common occurrence in psychiatric hospital settings, however population-based research among individuals with psychiatric disorders, in particular bipolar disorder (BD) is scant. Thus, we aimed to investigate falls risk in community-dwelling women diagnosed with BD.

Methods
Women with BD (cases, n = 119) were recruited from health care settings located in southeast Victoria, Australia. Age-matched controls (n = 357, ratio 3:1) without BD were participants in the Geelong Osteoporosis Study drawn from the same geographical region. Lifetime history of BD was identified by semi-structured clinical interview (SCID-IV/NP). Previous 12-month falls data were obtained via questionnaire. Information on mobility, alcohol use, general health, medication use, blood pressure, body mass index, socioeconomic status and use of a walking aid was collected. Generalised Estimating Equations, binary and ordinal logistic regression were used to determine the odds ratio (OR) and 95% confidence interval (CI) for falls following adjustment for confounders.

Results
During the 12-month period, 34 (28.6%, median age 48.4 yr) cases and 70 (19.6%, median age 49.1 yr) controls reported one fall; 22 (18.5%) cases and 18 (5.0%) controls reported ≥ two falls (p < 0.001). Cases had 2.5-fold increased odds of at least one fall and 2.9-fold increased likelihood of increasing falls categories (0 vs. 1 vs. 2 +), compared to controls [adjOR 2.5, 95%CI (1.8, 3.4), adjOR OR 2.9, 95%CI (2.0, 4.1)].

Conclusion
Risk of falls was greater among women with BD. Balance training could be a research and clinical focus for falls prevention programs among women with bipolar disorder to prevent the detrimental outcomes associated with falling.
Acute exposure to air pollutants increase the risk of acute glaucoma
Authors: Li Liping , Zhu Yixiang , Han Binze , Chen Renjie , Man Xiaofei , Sun Xinghuai , Kan Haidong , Lei Yuan 
Published: September 2022

Abstract
Background
Ambient air pollution is related to the onset and progression of ocular disease. However, the effect of air pollutants on the acute glaucoma remains unclear.

Objective
To investigate the effect of air pollutants on the incidence of acute glaucoma (acute angle closure glaucoma and glaucomatocyclitic crisis) among adults.

Methods
We conducted a time-stratified case-crossover study based on the data of glaucoma outpatients from January, 2015 to Dec, 2021 in Shanghai, China. A conditional logistic regression model combined with a polynomial distributed lag model was applied for the statistical analysis. Each case serves as its own referent by comparing exposures on the day of the outpatient visit to the exposures on the other 3–4 control days on the same week, month and year. To fully capture the delayed effect of air pollution, we used a maximum lag of 7 days in main model.

Results
A total of 14,385 acute glaucoma outpatients were included in this study. We found exposure to PM2.5, PM10, nitrogen dioxide (NO2) and carbon monoxide (CO) significantly increased the odds of outpatient visit for acute glaucoma. Wherein the odds of acute glaucoma related to PM2.5 and NO2 were higher and more sustained, with OR of 1.07 (95%CI: 1.03–1.11) and 1.12 (95% CI: 1.08–1.17) for an IQR increase over lag 0–3 days, than PM10 and CO over lag 0–1 days (OR:1.03; 95% CI: 1.01–1.05; OR: 1.04; 95% CI: 1.01–1.07).

Conclusions
This case-crossover study provided first-hand evidence that air pollutants, especially PM2.5 and NO2, significantly increased risk of acute glaucoma.
On the role of financial support programs in mitigating the SARS-CoV-2 spread in Brazil
Authors: Albani Vinicius V. L. , Albani Roseane A. S. , Bobko Nara , Massad Eduardo , Zubelli Jorge P. 
Published: September 2022

Abstract
Background
During 2020, there were no effective treatments or vaccines against SARS-CoV-2. The most common disease contention measures were social distance (social isolation), the use of face masks and lockdowns. In the beginning, numerous countries have succeeded to control and reduce COVID-19 infections at a high economic cost. Thus, to alleviate such side effects, many countries have implemented socioeconomic programs to fund individuals that lost their jobs and to help endangered businesses to survive.

Methods
We assess the role of a socioeconomic program, so-called “Auxilio Emergencial” (AE), during 2020 as a measure to mitigate the Coronavirus Disease 2019 (COVID-19) outbreak in Brazil. For each Brazilian State, we estimate the time-dependent reproduction number from daily reports of COVID-19 infections and deaths using a Susceptible-Exposed-Infected-Recovered-like (SEIR-like) model. Then, we analyse the correlations between the reproduction number, the amount of individuals receiving governmental aid, and the index of social isolation based on mobile phone information.

Results
We observed significant positive correlation values between the average values by the AE and median values of an index accounting for individual mobility. We also observed significantly negative correlation values between the reproduction number and this index on individual mobility. Using the simulations of a susceptible-exposed-infected-removed-like model, if the AE was not operational during the first wave of COVID-19 infections, the accumulated number of infections and deaths could be 6.5 (90% CI: 1.3–21) and 7.9 (90% CI: 1.5–23) times higher, respectively, in comparison with the actual implementation of AE.

Conclusions
Our results suggest that the AE implemented in Brazil had a significant influence on social isolation by allowing those in need to stay at home, which would reduce the expected numbers of infections and deaths.
Use of the behaviour change wheel to improve everyday person-centred conversations on physical activity across healthcare
Authors: Reid Hamish , Smith Ralph , Williamson Wilby , Baldock James , Caterson Jessica , Kluzek Stefan , Jones Natasha , Copeland Robert 
Published: September 2022

Abstract
Background
An implementation gap exists between the evidence supporting physical activity in the prevention and management of long-term medical conditions and clinical practice. Person-centred conversations, i.e. focussing on the values, preferences and aspirations of each individual, are required from healthcare professionals. However, many currently lack the capability, opportunity, and motivation to have these conversations. This study uses the Behaviour Change Wheel (BCW) to inform the development of practical and educational resources to help bridge this gap.

Methods
The BCW provides a theoretical approach to enable the systematic development of behaviour change interventions. Authors followed the described eight-step process, considered results from a scoping review, consulted clinical working groups, tested and developed ideas across clinical pathways, and agreed on solutions to each stage by consensus.

Results
The behavioural diagnosis identified healthcare professionals’ initiation of person-centred conversations on physical activity at all appropriate opportunities in routine medical care as a suitable primary target for interventions. Six intervention functions and five policy categories met the APEASE criteria. We mapped 17 Behavioural Change Techniques onto BCW intervention functions to define intervention strategies.

Conclusions
This study uses the BCW to outline a coherent approach for intervention development to improve healthcare professionals’ frequency and quality of conversations on physical activity across clinical practice. Time-sensitive and role-specific resources might help healthcare professionals understand the focus of their intervention. Educational resources aimed at healthcare professionals and patients could have mutual benefit, should fit into existing care pathways and support professional development. A trusted information source with single-point access via the internet is likely to improve accessibility. Future evaluation of resources built and coded using this framework is required to establish the effectiveness of this approach and help improve understanding of what works to change conversations around physical activity in clinical practice.
Exercise adherence Mobile app for Knee Osteoarthritis: protocol for the MappKO randomised controlled trial
Authors: Hinman Rana S. , Nelligan Rachel K. , Campbell Penny K. , Kimp Alexander J. , Graham Bridget , Merolli Mark , McManus Fiona , Lamb Karen E. , Bennell Kim L. 
Published: September 2022

AbstractBackgroundIn people with knee osteoarthritis (OA), ongoing exercise participation, particularly with strengthening exercises, is central to management. Patient adherence to prescribed exercise typically declines once consultations with a clinician have ceased. Mobile applications (apps) can incorporate behaviour change techniques that may assist adherence, potentially optimising clinical outcomes.MethodsThis is a two-arm, pragmatic, superiority randomised trial. One hundred and eighty two Australians with chronic knee pain (clinical knee OA) and who have at least a mild level of physical dysfunction are being recruited. Participants are randomly allocated i) exercise (physiotherapist-prescribed exercise) or; ii) exercise plus app (physiotherapist-prescribed exercise plus access to the ‘My Exercise Messages’ mobile app). Exercise care comprises two videoconferencing consultations with a physiotherapist over two weeks (30 min each) for a strengthening exercise program, which is then conducted independently at home for 24 weeks without any further physiotherapist consultations. Participants are also provided with exercise resources to facilitate home-based exercise. Those randomised to exercise plus app will download the app after completing the two weeks of physiotherapy consultations and will be instructed by research staff to use the app for the 24 weeks of unsupervised home-based exercises. The app works by tracking completion of weekly exercise sessions, providing regular messages to facilitate weekly exercise and providing personalised messages to help overcome individual barriers to exercise participation. The two primary outcomes are i) self-reported physical function; and ii) number of days strengthening exercises were performed (previous fortnight), with a primary endpoint of 26 weeks and a secondary endpoint of 14 weeks. Secondary outcomes include knee pain severity; knee-related quality of life; global change; exercise program satisfaction; exercise self-efficacy; physical activity; sport and recreation function; another measure of exercise adherence; and willingness to undergo joint replacement. Process measures are also included.DiscussionFindings will determine if a theory-informed mobile app improves exercise adherence and physical function in people with knee OA who have received a home-based strengthening program.Trial RegistrationAustralian New Zealand Clinical Trials Registry, ACTRN12621000724875. Prospectively registered 9/06/2021.
Enterococcus faecalis rnc gene modulates its susceptibility to disinfection agents: a novel approach against biofilm
Authors: Xia Mengying , Zhuo Niya , Ren Shirui , Zhang Hongyu , Yang Yingming , Lei Lei , Hu Tao 
Published: September 2022

AbstractBackgroundEnterococcus faecalis(E. faecalis) plays an important role in the failure of root canal treatment and refractory periapical periodontitis. As an important virulence factor ofE. faecalis, extracellular polysaccharide (EPS) serves as a matrix to wrap bacteria and form biofilms. The homologousrncgene, encoding Ribonuclease III, has been reported as a regulator of EPS synthesis. In order to develop novel anti-biofilm targets, we investigated the effects of therncgene on the biological characteristics ofE. faecalis, and compared the biofilm tolerance towards the typical root canal irrigation agents and traditional Chinese medicine fluid Pudilan.MethodsE. faecalis rncgene overexpression (rnc+) and low-expression (rnc−) strains were constructed. The growth curves ofE. faecalisATCC29212,rnc+, andrnc− strains were obtained to study the regulatory effect of therncgene onE. faecalis. Scanning electron microscopy (SEM), confocal laser scanning microscopy (CLSM), and crystal violet staining assays were performed to evaluate the morphology and composition ofE. faecalisbiofilms. Furthermore, the wild-type and mutant biofilms were treated with 5% sodium hypochlorite (NaOCl), 2% chlorhexidine (CHX), and Pudilan. The residual viabilities ofE. faecalisbiofilms were evaluated using crystal violet staining and colony counting assays.ResultsThe results demonstrated that therncgene could promote bacterial growth and EPS synthesis, causing the EPS-barren biofilm morphology and low EPS/bacteria ratio. Both thernc+ andrnc− biofilms showed increased susceptibility to the root canal irrigation agents. The 5% NaOCl group showed the highest biofilm removing effect followed by Pudilan and 2% CHX. The colony counting results showed almost complete removal of bacteria in the 5% NaOCl, 2% CHX, and Chinese medicine agents’ groups.ConclusionsThis study concluded that therncgene could positively regulate bacterial proliferation, EPS synthesis, and biofilm formation inE. faecalis. Therncmutation caused an increase in the disinfectant sensitivity of biofilm, indicating a potential anti-biofilm target. In addition, Pudilan exhibited an excellent ability to removeE. faecalisbiofilm.
Changes in on-time vaccination following the introduction of an electronic immunization registry, Tanzania 2016-2018: interrupted time-series analysis
Authors: Dolan Samantha B. , Burstein Roy , Shearer Jessica C. , Bulula Ngwegwe , Lyons Hil , Carnahan Emily , Beylerian Emily , Thompson Jenny , Puttkammer Nancy , Lober William B. , Liu Shan , Gilbert Skye S. , Werner Laurie , Ryman Tove K. 
Published: September 2022

Abstract
Background
Digital health interventions (DHI) have the potential to improve the management and utilization of health information to optimize health care worker performance and provision of care. Despite the proliferation of DHI projects in low-and middle-income countries, few have been evaluated in an effort to understand their impact on health systems and health-related outcomes. Although more evidence is needed on their impact and effectiveness, the use of DHIs among immunization programs has become more widespread and shows promise for improving vaccination uptake and adherence to immunization schedules.

Methods
Our aim was to assess the impact of an electronic immunization registry (EIR) using an interrupted time-series analysis to analyze the effect on proportion of on-time vaccinations following introduction of an EIR in Tanzania. We hypothesized that the introduction of the EIR would lead to statistically significant changes in vaccination timeliness at 3, 6, and > 6 months post-introduction.

Results
For our primary analysis, we observed a decrease in the proportion of on-time vaccinations following EIR introduction. In contrast, our sensitivity analysis estimated improvements in timeliness among those children with complete vaccination records. However, we must emphasize caution interpreting these findings as they are likely affected by implementation challenges.

Conclusions
This study highlights the complexities of using digitized individual-level routine health information system data for evaluation and research purposes. EIRs have the potential to improve vaccination timeliness, but analyses using EIR data can be complicated by data quality issues and inconsistent data entry leading to difficulties interpreting findings.