bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical Method Development and Validation for Simultaneous Estimation of Naproxen and Esomeprazole in Pharmaceutical Dosage Forms
Authors: Kulsum Syeda , Naz Ayesha , Rehman Abdul , Bari Abdul , Salman Mohammed , Jabeen Shayestha , Akhter Samreen 
Published: October 2022

Introduction: An accurate, specific and precise reverse phase UV spectrophotometric method was developed for the simultaneous estimation of Naproxen and Esomeprazole in tablet dosage form. Naproxen and Esomeprazole tablets were used to relieve the spondylitis, osteoarthritis and rheumatoid arthritis in adults’ juvenile idiopathic arthritis in children.
Methods: Simple and accurate UV spectroscopic method was developed using Naproxen and Esomeprazole tablet and results were tabulated.
Results and Discussion: The optimum conditions were established for the analysis of the drug. The maximum wavelength of Naproxen (λmax) was found to be 231nm and for Esomeprazole was 301nm respectively. The linearity of the method developed was in the range 10-50 μg/ml for Naproxen and 30-70 μg/ml for Esomeprazole. Calibration curves for Naproxen and Esomeprazole showed a linear relationship among the absorbance and concentration. The line equation observed for Naproxen is Y= 0.0374X + 0.0805 with r2 of 0.9936 and for Esomeprazole drug was 0.0377 X+0.0576 with R2 of 0.9962 . Validation parameters were performed as per ICH guidelines for all validation parameters like linearity, accuracy, precision, LOD and LOQ. The results of LOD and LOQ were found to be within the range.
Conclusion: The proposed method for Naproxen and Esomeprazole was simple, yet sensitive and precise for repeated analysis of Naproxen and esomeprazole in bulk and tablet formulations.
Clinician Diagnostic Certainty and the Role of the Autism Diagnostic Observation Schedule in Autism Spectrum Disorder Diagnosis in Young Children
Authors: Barbaresi William , Cacia Jaclyn , Friedman Sandra , Fussell Jill , Hansen Robin , Hofer Johannes , Roizen Nancy , Stein Ruth E. K. , Vanderbilt Douglas , Sideridis Georgios 
Published: October 2022

ImportanceAutism spectrum disorder (ASD) affects 1 in 44 children. The Autism Diagnostic Observation Schedule (ADOS) is a semi-structured observation developed for use in research but is considered a component of gold standard clinical diagnosis. The ADOS adds time and cost to diagnostic assessments.ObjectiveTo evaluate consistency between clinical diagnosis (index ASD diagnosis) and diagnosis incorporating the ADOS (reference standard ASD diagnosis) and to examine clinician and child factors that predict consistency between index diagnoses and reference standard diagnoses.Design, Setting, and ParticipantsThis prospective diagnostic study was conducted between May 2019 and February 2020. Developmental-behavioral pediatricians (DBPs) made a diagnosis based on clinical assessment (index ASD diagnosis). The ADOS was then administered, after which the DBP made a second diagnosis (reference standard ASD diagnosis). DBPs self-reported diagnostic certainty at the time of the index diagnoses and reference standard diagnoses. The study took place at 8 sites (7 US and 1 European) that provided subspecialty assessments for children with concerns for ASD. Participants included children aged 18 months to 5 years, 11 months, without a prior ASD diagnosis, consecutively referred for possible ASD. Among 648 eligible children, 23 refused, 376 enrolled, and 349 completed the study. All 40 eligible DBPs participated.ExposuresADOS administered to all child participants.Main Outcomes and MeasuresIndex diagnoses and reference standard diagnoses of ASD (yes/no).ResultsAmong the 349 children (279 [79.7%] male; mean [SD] age, 39.9 [13.4] months), index diagnoses and reference standard diagnoses were consistent for 314 (90%) (ASD = 250; not ASD = 64) and changed for 35. Clinician diagnostic certainty was the most sensitive and specific predictor of diagnostic consistency (area under curve = 0.860; P &amp;lt; .001). In a multilevel logistic regression, no child or clinician factors improved prediction of diagnostic consistency based solely on clinician diagnostic certainty at time of index diagnosis.Conclusions and RelevanceIn this prospective diagnostic study, clinical diagnoses of ASD by DBPs with vs without the ADOS were consistent in 90.0% of cases. Clinician diagnostic certainty predicted consistency of index diagnoses and reference standard diagnoses. This study suggests that the ADOS is generally not required for diagnosis of ASD in young children by DBPs and that DBPs can identify children for whom the ADOS may be needed.
Predicting the foraging patterns of wintering Auks using a sea surface temperature model for the Barents Sea
Authors: Hodges Samuel , Erikstad Kjell Einar , Reiertsen Tone Kirsten 
Published: October 2022

Abstract
The conservation of seabirds is increasingly important for their role as indicator species of ocean ecosystems, which are predicted to experience increasing levels of exploitation this century. Safeguarding these ecosystems will require predictive, spatial studies of seabird foraging hotspots. Current research on seabird foraging hotspots has established a significant relationship between probability of presence and several environmental variables, including Sea Surface Temperature (SST). However, inter‐annual, basin‐wide variation has the potential to invalidate these models, which depend on seasonal mesoscale variability.

In this study, we present a novel solution to predict presence from spatially and temporally variable environmental predictors, while reducing the influence of large‐scale basin‐wide variation. We model the Maximum Entropy (MaxENT) Model‐derived relationship between Standardized Monthly SST (StdSST) and Habitat Suitability using Gaussian curve models, and then apply these models to independent StdSST data to produce heatmaps of predicted seabird presence.

In this study, we demonstrate StdSST to be a functional environmental predictor of seabird presence, within a Gaussian curve model framework. We demonstrate accurate predictions of the model's training data and of independent seabird presence data to a high degree of accuracy (area under the receiver operator characteristic curve > 0.65) for four species of Auk: Common Guillemots (Uria aalge), Razorbills (Alca torda), Atlantic Puffins (Fratercula arctica) and Brunnich's Guillemots (Uria lomvia).

We believe that the methodology we have developed and tested in this study can be used to guide ecosystem management practices by converting coupled‐climate model predictions into predictions of future presence based on Habitat Suitability for the species, allowing us to consider the possible effects of climate change and yearly variation of SST on foraging seabird hotspots in the Barents Sea.
Application value of contrast‐enhanced ultrasound in preoperative localization of microwave ablation for primary hyperparathyroidism
Authors: Liu Fangyi , Zang Li , Li Yunlin , Guan Zhiwei , Liu Yang , Yu Xiaoling , Han Zhiyu , Liang Ping 
Published: October 2022

AbstractBackgroundUltrasonography (US) and 99mTechnetium‐sestamibi scintigraphy (99mTc‐MIBI) are currently first‐line imaging modalities to localize parathyroid adenomas with sensitivities of 80% and 84%, respectively. Therefore, finding other modalities to further improve the diagnostic accuracy for preoperative localization is critically needed.PurposeTo evaluate the application value of contrast‐enhanced ultrasound (CEUS) in the preoperative localization of microwave ablation (MWA) for primary hyperparathyroidism (PHPT).MethodsBetween December 2012 and May 2021, 100 PHPT patients (34 males and 66 females; mean age, 56.31 ± 13.43 years; age range, 25–85 years) with 130 suspected parathyroid nodules were enrolled. US, CEUS, and 99mTc‐MIBI were performed for the localization of pathological parathyroid glands. All patients were performed MWA under ultrasound guidance. All the suspected parathyroid nodules underwent core needle biopsy under ultrasound guidance during MWA to confirm the pathology. The diagnostic performance of all the imaging tests was analyzed in comparison with the pathological results.ResultsA total of 130 nodules suspected to be of parathyroid origin from preoperative localization images were confirmed by pathological results, of which 116 were of parathyroid origin, and 14 were not of parathyroid origin. The sensitivity, specificity, accuracy, and the area under receiver operating characteristic curve of CEUS in the localization of pathological parathyroid glands were 100%, 92.86%, 99.23%, and 0.964, which were significantly higher than those of US (93.10%, 42.86%, 87.69%, and 0.680) and 99mTc‐MIBI (81.90%, 42.86%, 77.69%, and 0.624) (p < 0.05). The sensitivity and accuracy of CEUS were 100% and 97.22%, which were higher than those of 99mTc‐MIBI (65.62% and 63.89%) or US (75.00% and 72.22%) in patients with multiple parathyroid glands (p < 0.05). For smaller parathyroid adenomas (≤2 cm in diameter), the sensitivities of CEUS in locating hyperfunctioning parathyroid glands were 100%, which was significantly higher than that of 99mTc‐MIBI (73.68% and 84.31%, p < 0.05).ConclusionsCEUS is a valuable preoperative localization method for PHPT patients performed MWA, especially for the patients with smaller pathological parathyroid gland and multiple glandular lesions.
Reconciling Between Medication Orders and Medication Fills for Lupus in Pregnancy
Authors: Simard Julia F. , Liu Emily F. , Chakravarty Eliza , Rector Amadeia , Cantu Miranda , Kuo Daniel Z. , Shaw Gary M. , Druzin Maurice , Weisman Michael H. , Hedderson Monique M. 
Published: October 2022

ObjectiveMost studies consider either medications ordered or filled, but not both. Medication underuse based on filling data cannot necessarily be ascribed to patient nonadherence. Using both data sources, we quantified primary medication adherence in a cohort of prevalent systemic lupus erythematosus (SLE) pregnancies.MethodsWe identified 419 pregnancies in Kaiser Permanente Northern California in patients with prevalent SLE from 2011 to 2020. We calculated the number of physician‐initiated orders or pharmacy‐initiated reorders during pregnancy and a comparable 9‐month window the year before (prepregnancy) and the proportion of orders ever filled and filled within 30 days for hydroxychloroquine (HCQ), azathioprine, and corticosteroids. For pregnancies without an order or reorder, we identified the proportion with previous prescription fills overlapping into the respective study period.ResultsNew orders for lupus medications were usually filled. HCQ was prescribed most often (45.8% pregnancies) and usually filled (89.7% in prepregnancy, 93.2% during pregnancy). The majority filled within 30 days (80.5% prepregnancy, 83.3% pregnancy). Some pregnancies without new HCQ orders had continuous refills from prior orders; 53% of 2011–2015 pregnancies either had a new order or fill coverage from a previous period, compared to 63.2% of pregnancies delivering in 2016–2019. Corticosteroid fill frequencies were 90.6% in prepregnancy and 83.6% during pregnancy. Fewer patients used azathioprine; however, most new orders were filled (94.3% prepregnancy, 91.7% pregnancy). For azathioprine and corticosteroids, fill rates were modestly higher in prepregnancy compared to pregnancy.ConclusionWe observed that patients have high adherence to filling new orders for lupus medications, such as HCQ and azathioprine, in pregnancy.
Nickel Hydroxide‐Supported Ru Single Atoms and Pd Nanoclusters for Enhanced Electrocatalytic Hydrogen Evolution and Ethanol Oxidation
Authors: Pei An , Li Guang , Zhu Lihua , Huang Zinan , Ye Jinyu , Chang Yu‐Chung , Osman Sameh M. , Pao Chih‐Wen , Gao Qingsheng , Chen Bing Hui , Luque Rafael 
Published: October 2022

AbstractThe rational fabrication of Pt‐free catalysts for driving the development of practical applications in alkaline water electrolysis and fuel cells is promising but challenging. Herein, a promising approach is outlined for the rational design of multimetallic catalysts comprising multiple active sites including Pd nanoclusters and Ru single atoms anchored at the defective sites of Ni(OH)2 to simultaneously enhance hydrogen evolution reactions (HER) and ethanol oxidation reactions (EOR). Remarkably, Pd12Ru3/Ni(OH)2/C exhibits a remarkably reduced HER overpotential (16.1 mV@10 mA cm−2 with a Tafel slope of 21.8 mV dec−1) as compared to commercial 20 wt.% Pt/C (26.0 mV@10 mA cm−2, 32.5 mV dec−1). More importantly, Pd12Ru3/Ni(OH)2/C possesses a self‐optimized overpotential to 12.5 mV@10 mA cm−2 after 20 000 cycles stability test while a significantly decreased performance for commercial 20wt.% Pt/C (64.5 mV@10 mA cm−2 after 5000 cycles). The mass activity of Pd12Ru3/Ni(OH)2/C for the EOR is up to 3.724 A mgPdRu−1, ≈20 times higher than that of commercial Pd/C. Electrochemical in situ Fourier transform infrared measurements confirm the enhanced CO2 selectivity of Pd12Ru3/Ni(OH)2/C while synergistic and electronic effects of adjacent Ru, Pd, and OHad adsorption on Ni(OH)2 at low potential play a key role during EOR.
Magnetically‐Assisted 3D Bioprinting of Anisotropic Tissue‐Mimetic Constructs
Authors: Pardo Alberto , Bakht Syeda Mahwish , Gomez‐Florit Manuel , Rial Ramón , Monteiro Rosa F. , Teixeira Simão P. B. , Taboada Pablo , Reis Rui L. , Domingues Rui M. A. , Gomes Manuela E. 
Published: October 2022

AbstractRecreating the extracellular matrix organization and cellular patterns of anisotropic tissues in bioengineered constructs remains a significant biofabrication challenge. Magnetically‐assisted 3D bioprinting strategies can be exploited to fabricate biomimetic scaffolding systems, but they fail to provide control over the distribution of magnetic materials incorporated in the bioinks while preserving the fidelity of the designed composites. To overcome this dichotomy, the concepts of magnetically‐ and matrix‐assisted 3D bioprinting are combined here. By allowing low viscosity bioinks to remain uncrosslinked after printing, this approach enables the arrangement of incorporated magnetically‐responsive microfibers without compromising the resolution of printed structures before inducing their solidification. Moreover, the fine design of these magnetic microfillers allows the use of low inorganic contents and weak magnetic field strengths, minimizing the potentially associated risks. This strategy is evaluated for tendon tissue engineering purposes, demonstrating that the synergy between the biochemical and biophysical cues stemming from a tendon‐like anisotropic fibrous microstructure, combined with remote magneto‐mechanical stimulation during in vitro maturation, is effective on directing the fate of the encapsulated human adipose‐derived stem cells toward tenogenic phenotype. In summary, the developed strategy allows the fabrication of anisotropic high‐resolution magnetic composites with remote stimulation functionalities, opening new horizons for tissue engineering applications.
Multiplying Phosphine‐Oxide Orientation to Enable Ultralow‐Voltage‐Driving Simple White Thermally Activated Delayed Fluorescence Diodes with Power Efficiency over 100 lm W−1
Authors: Zhang Jing , Sun Jianan , Ma Yuanxin , Han Chunmiao , Ding Dongxue , Wei Ying , Xu Hui 
Published: October 2022

AbstractThermally activated delayed fluorescence (TADF) white organic light‐emitting diodes (WOLED) hold great potential for daily lightings, but should overcome the current limitation in power conservation. Despite amount of efforts on developing efficient TADF emitters, it is demonstrated here that the host matrix actually controls exciton formation and allocation, therefore strongly determines power efficiency. Through multiplying P≐O orientations, 248DBTTPO matrix establishes “diffusion predominance” mode to support multidirectional carrier/exciton migration, which combines the advantages of “recombination predominance” and “transport predominance” modes in alleviating dopant–dopant interactions and rationalizing carrier and energy transfer. 248DBTTPO matrix effectively balances carrier flux, singlet radiation, and triplet quenching suppression of TADF emitters, and exciton allocation in its complementary white TADF systems. As consequence, 248DBTTPO endows its trilayer single‐emissive‐layer WOLEDs with the state‐of‐the‐art external quantum efficiency up to 27%, ultralow driving voltages, and consequently the record‐high power efficiency of 108.6 lm W−1, which breaks through key bottleneck of TADF lighting.
Polymer‐Reinforced Liposomes Amplify Immunogenic Cell Death‐Associated Antitumor Immunity for Photodynamic‐Immunotherapy
Authors: Zhao Yu , Chen Zihan , Li Qiushi , Cao Xianghui , Huang Qingqing , Shi Linqi , Liu Yang 
Published: October 2022

AbstractPhotodynamic therapy has emerged as a promising tool for inducing immunogenic cell death (ICD), which shows the potential to convert tumor cells into in situ vaccines. However, large amounts of as‐generated tumor‐associated antigens (TAAs) are entrapped in the endo‐lysosomes of tumor‐infiltrating dendritic cells (DCs), resulting in unsatisfactory TAA cross‐presentation and poor or moderate ICD‐associated antitumor responses. Herein, an immune‐enhancing polymer‐reinforced liposome (IERL) with a stable nanostructure and a bioactive surface is developed and it demonstrates its capability to collect TAAs, facilitates TAA endo‐lysosomal escape in DCs, and enhances cross‐presentation of TAAs, which results in the amplification of ICD‐associated antitumor immune responses. By loading photosensitizers, IERLs are able to induce robust antitumor immune responses and immune memory after local irradiation, thereby inhibiting the growth of both primary and distant/metastatic tumors. Additionally, considering the wide applications of liposomal carriers, photosensitizers in IERLs can be easily replaced with photothermal agents and radiosensitizers (or their combinations), which provides a general platform for the rapid development of combined cancer immunotherapy.
ZIF@VO2 as an Intelligent Nano‐Reactor for On‐Demand Angiogenesis and Disinfection
Authors: Yuan Tiejun , Wang Hui , Tan Minhong , Xu Yang , Xiao Qiyao , Wu Chen , Peng Lihua 
Published: October 2022

AbstractAbsent angiogenesis and bacterial infection are two major challenges that simultaneously delay the repair of injured tissues and organs. However, most current therapeutic systems deliver therapeutic cues in a separate and inaccurate manner which stimulates angiogenesis or inhibits infection leading to limited repair and side effects. Advanced therapeutic systems capable of providing accurate angiogenic stimulation and anti‐infection signals in response to the changing microenvironment are urgently needed. Herein, a nano‐reactor (ZFVO) involving zeolitic imidazolate framework‐67 (ZIF‐67)‐deposited hollow vanadium oxide (VO2) is developed to intelligently execute pro‐angiogenesis and/or disinfection via the responsive release of cobalt ions and hydroxyl radicals to the injury and infection sites, respectively. ZFVO nano‐reactor demonstrates a novel strategy for constructing drug‐free nano‐platforms with a hierarchical structure which has potential for the accurate treatment of trauma and orthopedic diseases.
Room‐Temperature Magnetic Skyrmions and Large Topological Hall Effect in Chromium Telluride Engineered by Self‐Intercalation
Authors: Zhang Chenhui , Liu Chen , Zhang Junwei , Yuan Youyou , Wen Yan , Li Yan , Zheng Dongxing , Zhang Qiang , Hou Zhipeng , Yin Gen , Liu Kai , Peng Yong , Zhang Xi‐Xiang 
Published: October 2022

AbstractRoom‐temperature magnetic skyrmion materials exhibiting robust topological Hall effect (THE) are crucial for novel nano‐spintronic devices. However, such skyrmion‐hosting materials are rare in nature. In this study, a self‐intercalated transition metal dichalcogenide Cr1+xTe2 with a layered crystal structure that hosts room‐temperature skyrmions and exhibits large THE is reported. By tuning the self‐intercalate concentration, a monotonic control of Curie temperature from 169 to 333 K and a magnetic anisotropy transition from out‐of‐plane to the in‐plane configuration are achieved. Based on the intercalation engineering, room‐temperature skyrmions are successfully created in Cr1.53Te2 with a Curie temperature of 295 K and a relatively weak perpendicular magnetic anisotropy. Remarkably, a skyrmion‐induced topological Hall resistivity as large as ≈106 nΩ cm is observed at 290 K. Moreover, a sign reversal of THE is also found at low temperatures, which can be ascribed to other topological spin textures having an opposite topological charge to that of the skyrmions. Therefore, chromium telluride can be a new paradigm of the skyrmion material family with promising prospects for future device applications.
N ‐(2‐aminoethyl) Acetamide Additive Enables Phase‐Pure and Stable α‐FAPbI3 for Efficient Self‐Powered Photodetectors
Authors: Cheng Wenjie , He Xiang , Wang Jian‐Gan , Tian Wei , Li Liang 
Published: October 2022

AbstractFormamidinium–lead triiodide (FAPbI3) perovskite is considered as one of the most promising perovskite materials for high‐performance photodetectors because of its narrow bandgap and superior thermal stability. Nevertheless, to realize efficient carrier transport and highly performing photodetectors, it imposes the requirement of fabricating α‐FAPbI3 with pure phase, preferred crystal orientation, large grain size, and passivated interface, which still remains challenging. Here, a facile strategy based on additive engineering to obtain pure‐phase FAPbI3 perovskite films by introducing N‐(2‐aminoethyl) acetamide into perovskite precursors is reported. The formation of chemical bond and hydrogen bond between N‐(2‐aminoethyl) acetamide and perovskite reduces the potential barrier in the phase‐transition process from an intermediate yellow phase to a final black phase, passivates the defects of the film, and leads to a high‐quality and phase‐pure α‐FAPbI3 perovskite. A self‐powered photodetector based on the as‐fabricated FAPbI3 film exhibits a maximum responsivity of 0.48 A W−1 at 700 nm with a peak external quantum efficiency of 95% at 440 nm. Moreover, the optimized device remains 83% of the initial performance after 576 h storage at ambient condition. This work provides a simple and feasible scheme for the preparation of high‐quality phase‐pure α‐FAPbI3 perovskite and associated devices.
Engineering Metal–Phenolic Networks for Solar Desalination with Directional Salt Crystallization
Authors: Wang Zhenxing , Gao Jie , Zhou Jiajing , Gong Jingwen , Shang Longwen , Ye Haobin , He Fang , Peng Shaoqin , Lin Zhixing , Li Yuexiang , Caruso Frank 
Published: October 2022

AbstractSolar desalination is one of the most promising strategies to address the global freshwater shortage crisis. However, the residual salt accumulated on the top surface of solar evaporators severely reduces light absorption and steam evaporation efficiency, thus impeding the further industrialization of this technology. Herein, a metal–phenolic network (MPN)‐engineered 3D evaporator composed of photothermal superhydrophilic/superhydrophobic sponges and side‐twining hydrophilic threads for efficient desalination with directional salt crystallization and zero liquid discharge is reported. The MPN coatings afford the engineering of alternating photothermal superhydrophilic/superhydrophobic sponges with high heating efficiency and defined vapor escape channels, while the side‐twining threads induce site‐selective salt crystallization. The 3D evaporator exhibits a high and stable indoor desalination rate (≈2.3 kg m−2 h−1) of concentrated seawater (20 wt%) under simulated sun irradiation for over 21 days without the need for salt crystallization inhibitors. This direct desalination is also achieved in outdoor field operations with a production rate of clean water up to ≈1.82 kg m−2 h−1 from concentrated seawater (10 wt%). Together with the high affinity and multiple functions of MPNs, this work is expected to facilitate the rational design of solar desalination devices and boost the research translation of MPN materials in broader applications.