bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reallocating time to physical activity and sleep: Associations with Quality of Life in cancer survivors
Authors: Hidde Mary C , Lyden Kate , Henry Kim , Leach Heather J 
Published: March 2022

Abstract
Purpose
Quality of Life (QOL) is an important psychosocial outcome in cancer survivors (CS). Physical activity (PA), reducing sedentary time (ST), and sleep can help CS improve QOL, however these behaviors are commonly studied in isolation, despite their interdependence during the 24-hour day (i.e., time in one activity cannot increase without time decreasing in another activity). This study examined the effects of reallocating time between moderate to vigorous PA (MVPA), light PA, ST, and sleep on QOL in a mixed sample of CS.
Methods
A cross-sectional sample of CS (N = 73) diagnosed with breast (29.7%), colorectal (33.8%), or other (36.5%) cancer. MVPA, light PA, and ST were measured using the activPAL™ accelerometer, and sleep duration using the Actiwatch™ accelerometer. Both were worn for 7-days, 24-hours per day. QOL was self-reported using the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire. Isotemporal substitution models were used to reallocate 30-minutes between activities. Statistical significance was set at p < .05.
Results
Participants accumulated, M = 24.0 ± 18.9 minutes/day of MVPA, 291.7 ± 100.4 minutes/day of light PA, 593.1 ± 108.3 minutes/day of ST, and 486.6 ± 57.6 minutes/night of sleep. Isotemporal substitution effects for reallocating time between MVPA, light PA, ST and sleep were not significantly associated with QOL.
Conclusions
Findings from this study suggest that among CS who are achieving adequate levels of PA and sleep, changes in 30-minutes of these activities may not impact QOL. Future studies should aim to recruit a larger, more representative sample and explore the role of bouted activity time.
Extending the visible light absorption of NH2-UiO-66 through diazotization reaction for photocatalytic chromium (VI) reduction
Authors: Hosseini Mahdiyeh-Sadat , Abbasi Alireza , Masteri-Farahani Majid 
Published: March 2022

Abstract
The optical properties of NH2-UiO-66 as a visible light-active metal organic framework was further enhanced through the diazotization reaction with π-conjugated 1-naphthol reagent. Diffuse reflectance UV-Vis spectrum of diazotized MOF, named as Azo-UiO-66, exhibited a significant red shift compared to unfunctionalized NH2-UiO-66 due to the formation of diazo compound. Also, Tauc calculations indicated considerable decrease in band gap energy from 2.68 to 1.7 eV, resulted in improvement of visible light harvesting. Furthermore, other physicochemical techniques e.g. X-ray diffraction (XRD), N2 adsorption-desorption analysis, thermogravimetric analysis (TGA), energy dispersive X-ray (EDX), and CHN elemental analyses demonstrated the successful MOF diazotization with 1-naphthol and preservation of NH2-UiO-66 framework upon post modification process. The reduction of hexavalent chromium, Cr(VI), as a serious contaminant in wastewater to less toxic Cr(III) was performed over prepared photocatalyst, which demonstrated the positive role of ligand functionalization and enhancement of visible light absorption on overall photocatalytic performance of Azo-UiO-66.
Emitting Laser Array of Coherent Beam Combination System Revisited: Angular Domain Perspective and the Fractal-Based Optimization
Authors: Hou Tianyue , Chang Qi , Ma Pengfei , Long Jinhu , Su Rongtao , Ma Yanxing , Zhou Pu 
Published: March 2022

Abstract
Coherent beam combination (CBC) of fiber lasers holds promise for achieving high brightness laser systems, which have given rise to widespread applications such as particle accelerator, space debris removal, and industrial fabrication. The emitting laser array of CBC systems offers intriguing features in terms of agile beam steering, flexible beam shaping, and high scalability for output power and array elements. However, the theoretical model of the laser array in CBC systems is less well explored beyond the routine angular-spectrum method, where methods for optimizing the laser array configuration are more limited. Here, we explore the theory for the laser array of CBC systems in the view of angular domain. The laser array is represented by the composition of angular harmonics, the orthogonal basis over the azimuthal plane, and we elucidate the formation of mainlobe and sidelobes of the far-field interference pattern by using the orbital angular momentum spectrum analysis and azimuthal decomposition. Based on our findings, a fractal-based laser array configuration is proposed to enhance the performance of the combining system. Our work offers a deeper insight into the theoretical study and application of laser beam combination and opens opportunities for the further optimization of CBC implementations.
Dexmedetomidine attenuates ferroptosis in OGD/R H9C2 cells through regulation of miR-326-5p/LCN2 axis
Authors: Huan Sheng , Ji Yihao , Yin Guoping 
Published: March 2022

Abstract
Myocardial ischemia-reperfusion injury (IRI) is a common complication in cardiac surgery. A series of cascade reactions occurs during IRI, including apoptosis, necrosis, autophagy and focal death. Ferroptosis, a new way of programmed death, has been found play key role in IRI. Alleviating ferroptosis may be a potential direction of IRI treatment. In this study, we found mir-326-5p was differently expressed in four myocardial injury-related GEO database. Importantly, it could affect cell activity and regulate ferroptosis in oxygen-glucose deprivation/reperfusion (OGD/R) H9C2 cells via acting on its target gene LCN2. Interestingly, besides ferroptosis, we also found that mir-326-5p/LCN2 axis had a synergistic effect on inflammatory response and autophagy in OGD/R H9C2. Notably, we identified dexmedetomidine (DEX) as a natural agonist of mir-326-5p. In general, DEX significantly increased the expression of mir-326-5p and decreased the expression of LCN2 in OGD/R H9C2 cells, clearing cellular Fe2+ and inhibiting ferroptosis.
Risk factors and mortality associated with undertriage after major trauma in a physician- led prehospital system: a retrospective multicentre cohort study
Authors: Benhamed Axel , Fraticelli Laurie , Claustre Clément , Cesareo Eric , Gossiome Amaury , Heidet Matthieu , Emond Marcel , Mercier Eric , Boucher Valérie , David Jean-Stéphane , Khoury Carlos El , Tazarourte Karim 
Published: March 2022

Abstract
Background
Direct transport of patients suffering major trauma to level-I trauma centres may reduce mortality. Emergency medical services therefore aim to limit undertriage so that all severely injured patients receive proper vital trauma care. Nevertheless, undertriage have been poorly examined in a physician-led prehospital system. The main objective of this study was to assess the incidence of undertriage. We also sought to determine its potential risk factors, as well as to assess its association with mortality.
Methods
A multicentre retrospective cohort study was performed using 2011–2017 data from a French regional trauma registry (RESUVal) that includes prehospital, and in-hospital data on trauma patients. All adults assessed by a physician-led mobile medical team with major trauma (Injury Severity Score [ISS] ≥ 16) were included. Major trauma patients transported directly to a level-I trauma centre were considered as correctly triaged. Multivariate logistic regression was used to identify factors associated with undertriage.
Results
7,110 trauma patients were screened, of whom 2,591 had an ISS ≥ 16. Median age was 42 (IQR 27–59) years old, 75.0% were male and 12.4% (n = 320) were undertriaged. In-hospital mortality was 18.3% among undertriaged patients vs 16.2% among correct-triaged patients (p = 0.473). Patients aged 51–65 years had higher risk for undertriage (OR = 1.60, 95%CI [1.11;2.26], p = 0.01). Conversely, mechanism (fall from height 0.62 [0.45;0.86], p = 0.01; gunshot/stab wounds 0.45 [0.22;0.90], p = 0.02), longer on-scene time (> 60 minutes, 0.62 [0.40;0.95], p = 0.03), prehospital endotracheal intubation (0.53 [0.39;0.71], p < 0.001), and prehospital focused assessment with sonography FAST (0.15 [0.08;0.29], p < 0.001) were associated with a lower risk for undertriage. After adjusting on severity, undertriage was not significantly associated with a greater risk of mortality (1.22 [0.80;1.89], p = 0.36).
Conclusions
In our region-wide, physician-led prehospital EMS system, undertriage in major trauma was higher than recommended and advanced age was associated with higher risk for undertriage. Conversely, a pre-hospital FAST was associated with a lower risk for undertriage. Specific triage procedures should be discussed in older trauma patients and further studies are needed to evaluate the impact of prehospital FAST on triage performance. We noted that undertriaged patients had no higher risk for mortality suggesting no impact of secondarily transfer and/or high trauma care quality in level-II trauma centres. Undertriage definition should be tailored to fit local trauma systems organization.
CT and MRI findings in gouty arthritis involving large joints of the upper extremities
Authors: Yuling Yang , Yongfei Guo , Shuiquan Yu , Zou Bin 
Published: March 2022

Abstract
Background
Gouty arthritis is a type of metabolic disease in which sodium urate crystals are deposited in the bone and joints, causing local inflammatory reactions and destruction of the bone tissue. Gouty arthritis involving the large joints of the upper extremities is rare in clinical practice. This study aimed to analyze the computed tomography (CT) and magnetic resonance imaging (MRI) findings of gouty arthritis primarily involving the large joints of the upper limbs, signal or density characteristics of the tophi, growth patterns, involvement of the adjacent joints, and differentiation from other lesions occurring in this area and to discuss the causes of misdiagnosis.
Methods
CT and MRI data were collected from 14 patients with gouty arthritis, primarily involving the shoulder and elbow joints, and their imaging features were analyzed.
Results
14 patients were aged between 28 and 85 years,All patients demonstrated nodular or mass-like abnormal signal shadows on CT, with equal or slightly long signals on T1-weighted image (WI) and short or slightly long signals on T2WI in the MRI. All 14 patients revealed narrowing of the affected joint space, with bone resorption and erosion under the joint surface of the larger tophis. The tophis grew around the joint, with anterolateral and posterolateral tophis observed predominantly in the shoulder joint, and dorsal tophis observed predominantly in the elbow joint on the MRI, with compression and edema of the surrounding soft tissues.
Conclusions
We analyzed patients with gouty arthritis involving the large joints of the upper extremities and observed an increased prevalence in young and middle-aged men who may have had clear tophi in the past.
Polo-like kinase 1 plays an oncogenic role in pan-cancer based on bioinformatics and biological assays
Authors: Luo Lin , Zhang Xiao-Yang , Zhen Ying-Wei , Liu Zhen , Peng Da-Zhao , Wei Cheng , Liu Xian-Zhi , Han Lei , Zhang Zhen-Yu 
Published: March 2022

Abstract
Polo-like kinases (PLKs) are crucial regulatory factors of the cell cycle process and their dysregulations often cause various diseases including tumorigenesis. Although the PLKs, including PLK1, have been extensively studied and reported, few pan-cancer analyses are attainable. The potential oncogenic roles of PLK1 were thus explored among different cancers according to various online websites and datasets. PLK1 is always overexpressed in many cancers, and there is a significant relationship between its expression and the prognosis of cancer patients. In addition, the enrichment analysis suggested that PLK1 might related to “cell cycle”, “DNA replication”, “mismatch repair”, and “immune response” in pan-cancer, especially in glioma. Therefore, the analyses about genetic alterations and immune in pan-cancer were conducted. Furthermore, flow cytometry, CCK8 and EdU assays can further verify the above results of enrichment analysis. Moreover, DNA methylation and ceRNA network were analyzed to explore the potential mechanisms of aberrant expression of PLK1. In conclusion, our research about the oncogenic roles of PLK1 in pan-cancer further supplemented the oncogenic mechanisms of PLK1 and developed new potential therapeutic directions.
Efficacy of Topical Treatment with Hyaluronate without Preservatives, Trehalose, and Steroids in the Management of Ocular Surface Disease Affecting Patients Under Treatment with Glaucoma Medications
Authors: Giorgi-Sandoval Luz A. , Paczka Jose , Ibáñez-Sandoval Miguel A. , Ortiz-Moreno Carlos D. , Guerrero-Cuevas Fabiola M. , Paczka-Giorgi Luz A. 
Published: March 2022

Abstract
Background
To study the efficacy of mixed topical regimens with hyaluronate, trehalose, and steroidal anti-inflammatory drugs in the treatment of intense ocular surface disease (OSD) in patients under topical antiglaucoma agents. Methods: A retrospective evaluation was conducted of 7415 medical records of consecutive patients visiting a glaucoma center throughout a 2-year period. The analysis included cases with complete information for patients under preserved topical antiglaucoma treatment who were diagnosed with ocular surface disease (OSD), the severity of which was determined using the OSD Index (OSDI) score. Variables investigated were signs and symptoms related to OSD and the type and duration of topical treatment. The efficacy of two mixed-treatment regimens containing a tear substitute without preservatives and a topical steroid were compared in patients with moderate/severe OSD. Treatments differed in the administration of trehalose (T+) or not (T-). Results: Of 5158 cases under topical antiglaucoma treatment, 2634 (51.06%) showed some signs of OSD, with 725 cases showing moderate/severe OSD. Of these 725 cases, 396 and 329 cases were placed in the T + and T- groups, respectively. In the T + group, a global clinical improvement of 76.47% (299/391) was found, versus 58.38% (188/322; p = 0.024) in the T- group. The outcome variables (OSDI, TBUT, and corneal fluorescein staining) improved significantly in both groups between their initial and final visits (at least two months apart). The mean of these variables was significantly better in the T + group during the final visit (p ≤ 0.01). Conclusion: An improvement in OSD variables associated with antiglaucoma drugs was observed, particularly in the group that used trehalose. Therefore, this agent should be considered for routine use in patients with OSD, especially for cases of moderate to severe intensity; it is most useful when associated with non-preserved artificial tears and topical steroids.
Bacterial Infiltration and Detorque at the Implant-Abutment Morse Taper Interface after masticatory simulation
Authors: Tuzita Alessandra Sayuri , Bella Ana Paula Granja Scarabel Nogueira , Suffredini Ivana Barbosa , Kojima Alberto Noriyuki , Giovani Elcio Magdalena , Mesquita Alfredo Mikail Melo 
Published: March 2022

Abstract
This study evaluated the bacterial infiltration and the detorque of indexed and non-indexed abutments of Morse taper implants (MTI) after mechanical cycling (MC). 40 MTI were distributed into four groups: IIA-indexed implant abutments; NIIA-non-indexed implant abutments; IIAMC-indexed implant abutments submitted to MC; NIIAMC-non-indexed implant abutments submitted to MC, which were carried out under one million 5Hz frequency and 3 Bar pressure. After mechanical cycling, all groups were immersed in a bacterial solution in Brain Heart Infusion Agar. After detorque, the bacteria infiltration was evaluated by counting the colony-forming units. For the bacterial infiltration analysis were applied the Kruskal-Wallis test (p = 0.0176) followed by Dunn’s test. For the detorque analysis, the two-way repeated measures ANOVA was applied, followed by the Tukey’s test (p < 0.0001). Bacteria infiltration was highly observed in NIIA (p = 0.0027),and was absent in IIAMC and NIIAMC. The detorque values for IIA (19.96Ncm ± 0.19Ncm), NIIA (19.90Ncm ± 0.83Ncm), and NIIAMC (19.51Ncm ± 0,69Ncm) were similar and remained close to the initial value, while IIAMC (55.2Ncm ± 2.36Ncm) showed an extremely significant torque value increase (p < 0.0001). The mechanical cycling resulted in mechanical sealing of the implant-abutment interface, preventing bacterial infiltration in the indexed and non-indexed specimens, and increasing the detorque strength in the group of indexed abutments.
Parent Activation and Traumatic Stress in the Pediatric Intensive Care Unit
Authors: Oelstrom Matthew J. , Gabor Rachel , Lee K. Jane , Mussatto Kathleen A. 
Published: March 2022

Abstract
Background
Nearly all parents in the PICU experience traumatic stress. Separately, parent activation is a measure of knowledge, confidence, and willingness to engage in the management of a child’s health. We aimed to identify associations between parent activation, parent traumatic stress, the passage of time, and factors that may influence parent traumatic stress in the PICU.
Methods
This was a single-center, prospective study of parents with a child in the PICU. Data were obtained via two surveys, one within 48 hours of PICU admission and a second one month later.
Results
A sample of 101 parents of 74 patients completed the initial survey. Of these, 44 completed the follow-up. Parent activation and traumatic stress near PICU admission were associated with activation (r = 0.61, p < 0.001) and traumatic stress (r = 0.63, p < 0.001) one month later, respectively. On admission, parents with more preexisting depression and anxiety reported more traumatic stress (r = 0.36, p = 0.001 and r = 0.35, p = 0.004), and parents who reported more background life stressors also reported more traumatic stress (r = 0.29, p = 0.002). One month after admission, parents who thought having a written daily schedule for their child was or could be helpful reported less stress (0.34 vs. 1.05, p = 0.001), and the more helpful they found the schedule, the less stress they reported (r=-0.65, p = 0.003). The perceived helpfulness of a chaplain correlated with parent activation at admission (r = 0.3, p = 0.009) and follow-up (r = .48, p = 0.007), and parental use of a support website was associated with higher parent activation at admission (80 vs. 70, p = 0.010).
Conclusions
Parent activation and parent traumatic stress symptoms within 48 hours of PICU admission predict activation and traumatic stress at one-month follow-up. Parent traumatic stress is associated with parent depression, anxiety, and background life stressors. It is inversely associated with the recognition, use, and perceived helpfulness of parent supports. Parent activation is positively associated with the recognition, use, and perceived helpfulness of supports. These findings advance the theory that parent activation is a relevant concept in the framework of factors that influence parent traumatic stress in the PICU.
Chronic, acute and protocol-dependent effects of exercise on psycho-physiological health during long-term isolation and confinement
Authors: Abeln Vera , Fomina E. , Popova J. , Braunsmann L. , Koschate J. , Möller F. , Fedyay S. O. , Vassilieva G. Y. , Schneider S. , Strüder H. K. , Klein T. 
Published: March 2022

Abstract
Exercise could prevent physical and psychological deteriorations, especially during pandemic times of lock-down scenarios and social isolation. But to meet both, the common exercise protocols require optimization based on holistic investigations and with respect to underlying processes. This study aimed to clarify individual chronic and acute effects of continuous and interval running exercise on physical and cognitive performance, mood, and affect and to explore underlying neurophysiological factors during a terrestrial simulated space mission.Six volunteers (three females) were isolated for 120 days. Accompanying exercise training consisted of continuous and interval running protocol a cross-over design. Incremental stage tests on a treadmill were done frequently to test physical performance. Actigraphy was used to monitor physical activity level. Cognitive performance, mood (MoodMeter®), affect (PANAS), brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), vascular-endothelial growth factor (VEGF), and saliva cortisol were investigated prior to, four times during, and after isolation, pre- and post-exercise on two separate days, respectively. As a chronic effect, physical performance increased (and IGF-1 tended) in the course of isolation and training until the end of isolation. Subjective mood and affect state, as well as cognitive performance, basal BDNF and VEGF levels, were well-preserved across the intervention. No acute effects of exercise were detected, besides slower reaction time after exercise in two out of nine cognitive tests, testing sensorimotor speed and memory of complex figures. Consistently higher basal IGF-1 concentrations and faster reaction time in the psychomotor vigilance test were found for the continuous compared to the interval running protocol. CONCLUSION: The results suggest that 120 days of isolation and confinement can be undergone without cognitive and mental deteriorations. Regular, individual exercise training is hypothesized to play an important role in this regard. Continuous running exercise seems to trigger higher IGF-1 levels and vigilance compared to interval running. Systematic and prolonged investigations and larger sample size are required to follow up on exercise-protocol specific differences in order to optimize the exercise intervention for long-term psycho-physiological health and well-being.
Health Literacy, Health Outcomes and Community Health Worker Utilization in HIV Primary Care
Authors: Freibott Christina E. , Sprague-Martinez Linda S , Rajabiun Serena , Drainoni Mari-Lynn 
Published: March 2022

Abstract
Background: People with HIV (PWH) have complex needs, and those with limited health literacy consistently have poorer HIV-related knowledge and health outcomes. One strategy to facilitate better outcomes for PWH is the inclusion of community health workers (CHWs) in care teams. This study examines the effect of health literacy on clinical outcomes and utilization of CHW services among PWH enrolled in a CHW intervention. The secondary aim is to characterize most common purposes of CHW encounters. Methods: Individuals (n=209) enrolled in a CHW intervention with completed 6-month follow-up evaluation visits were included. Health literacy level was measured at baseline with the BRIEF tool and categorized into inadequate, marginal, and adequate health literacy. Adjusted logistic regressions assessed the effect of health literacy on viral load suppression, HIV primary care visits at 6-month follow-up, CHW utilization and purpose of CHW encounter. Purpose of CHW encounters included logistical support, accompany to appointment, transportation coordination, concrete services, coaching, and emotional support. Linear regression assessed the association between purpose of CHW encounters and CHW utilization. Results: Individuals with inadequate health literacy were more likely to receive coaching from CHWs, and individuals with marginal health literacy were more likely to have an HIV primary care visit at 6 months. Individuals receiving transportation coordination, concrete services, coaching, and emotional support had more total CHW encounters. Conclusions: PWH often receive coaching from CHWs, particularly those with lower health literacy. The purpose of CHW encounter was associated with frequency of CHW encounters, indicating these types of services require more assistance from CHWs.