bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodal tract-based MRI metrics outperform whole brain markers in determining cognitive impact of small vessel disease related brain injury
Authors: De Luca Alberto , Kuijf Hugo , Exalto Lieza , de Schotten Michel Thiebaut , Biessels Geert-Jan 
Published: August 2022

Abstract
In cerebral small vessel disease (cSVD), whole brain MRI markers of cSVD-related brain injury explain limited variance to support individualized prediction. Here, we investigate whether considering abnormalities in brain tracts by integrating multimodal metrics from diffusion MRI (dMRI) and structural MRI (sMRI), can better capture cognitive performance in cSVD patients than established approaches based on whole brain markers. We selected 102 patients (73.7 ± 10.2 years old, 59 males) with MRI-visible SVD lesions and both sMRI and dMRI. Conventional linear models using demographics and established whole brain markers were used as benchmark of predicting individual cognitive scores. Multi-modal metrics of 73 major brain tracts were derived from dMRI and sMRI, and used together with established markers as input of a feed-forward artificial neural network (ANN) to predict individual cognitive scores. A feature selection strategy was implemented to reduce the risk of overfitting. Prediction was performed with leave-one-out cross validation and evaluated with the R2 of the correlation between measured and predicted cognitive scores. Linear models predicted memory and processing speed with R2 = 0.26 and R2 = 0.38, respectively. With ANN, feature selection resulted in 13 tract-specific metrics and 5 whole brain markers for predicting processing speed, and 28 tract-specific metrics and 4 whole brain markers for predicting memory. Leave-one-out ANN prediction with the selected features achieved R2 = 0.49 and R2 = 0.40 for processing speed and memory, respectively. Our results show proof-of-concept that combining tract-specific multimodal MRI metrics can improve the prediction of cognitive performance in cSVD by leveraging tract-specific multi-modal metrics.
Effect of an mHealth application on clinical outcomes in childhood asthma: Real-world, pragmatic trial in a primary care setting
Authors: Songnuy Theerapan , Chutiyon Wongwat , Nurak Awirut , Rungraungsilp Suppat 
Published: August 2022

Abstract
Medical adherence among children with asthma is a challenging problem. Mobile health applications have been increasingly used to improve adherence and clinical outcomes. Here, we compared clinical outcomes by using a mobile health application (Asmon application) with those receiving usual care, assessed the patient’s satisfaction and the usability of this tool. Methods: We conveniently allocated children with persistent asthma aged 4‒15 years and a guardian to receive the Asmon application or a usual care for 6 months. Assessments were performed at baseline and at the 6-month follow-up. Outcomes were the asthma control test score (ACT), dose of inhaled corticosteroids (ICS), acute exacerbation, and asthma-related quality of life. Participants’ satisfaction and reasons for unengaging in long-term use of the application were also analyzed. Results: The overall drop-out rate was 24.1% (intervention 13, 16.5%; control 6, 7.6%). The mean ACT scores had increased in both groups from baseline to the 6 months follow-up (intervention, p < 0.001; control p = 0.001), but did not differ significantly between groups (p = 0.784). Among those with poorly controlled asthma at baseline, the intervention group showed possibly higher improvement than the control (37.5% vs 16.7%) even though the value was not significantly different (p = 0.128). Acute exacerbation, median dose of ICS usage, and asthma-related quality of life were not significantly different between groups (p = 0.554, 0.555, and 0.627, respectively). Approximately one-third of the intervention group never used the application, while 40.5% ever used only 1‒7 times during the study period. Perception regarding the application was hard-to-use, self-judged ICS discontinuation, and change in guardians were the main obstacles for regular engagement. Nevertheless, the satisfaction score on the rating scale was high (4.5/5.0).Conclusion: The interactive Asmon application potentially improved disease control only in children with poorly controlled asthma at baseline. Acute exacerbation rate, dose of ICS, and asthma-related quality of life were not impacted by the intervention. Healthcare providers should thoroughly consider participants’ and guardians’ background characteristics before implementing an mHealth application in the real-world daily practices.
Integrated exercise program in opioid agonist therapy clinics and effect on psychological distress: Study protocol for a randomised controlled trial (BAReAktiv)
Authors: Furulund Einar , Madebo Tesfaye , Druckrey-Fiskaaen Karl Trygve , Vold Jørn Henrik , Nordbotn Mette Hegland , Dahl Eivin , Dyrstad Sindre Mikael , Lid Torgeir Gilje , Fadnes Lars Thore 
Published: August 2022

Abstract
Background
Substance use disorder is associated with unhealthy lifestyle choices, resulting in adverse social and health consequences. People with opioid use disorder receiving opioid agonist therapy, in particular, have high morbidity and reduced quality of life. Physical activity is recommended as an adjunctive treatment for people with substance use disorder, but there is minimal evidence from randomized controlled trials on effect of this among people with substance use disorder receiving opioid agonist therapy.
Methods
BAReAktiv is a multicentre randomised controlled trial. The study aims to recruit 324 patients receiving opioid agonist therapy (randomised 1:1 to integrated exercise intervention or control). A 16-week group-based integrated exercise intervention with workouts twice a week. The exercise program consists of endurance and resistance training. The target group will be patients 18 years and older receiving opioid agonist therapy in outpatient clinics in several centres in Western Norway. The primary outcome of the study is the effect on psychological distress measured by Hopkins’ symptom checklist with ten items. Secondary outcome measures include physical functioning assessed with a 4-minutes step-test, activity level, fatigue symptoms, quality of life and changes in inflammation markers. This study will provide improved knowledge on the effects of an integrated exercise program in opioid agonist therapy.
Discussion
Systematically integrating exercise programs for people receiving opioid agonist therapy could lead to a shift towards a stronger focus on health behaviours in outpatient care. Integrating exercise could benefit patient recovery and reduce disease burden. Further scale-up will be considered if the provided exercise program is safe and effective.
Trial Registration
: ClinicalTrials.gov.no NCT05242848. Date of registry February 16, 2022. Integrated Exercise Program in Opioid Agonist Therapy Clinics - Full Text View - ClinicalTrials.gov
Student Performance in Medical Biochemistry and Genetics: Comparing Campus-based versus Zoom-based Lecture Delivery
Authors: Faner Martha Audra , Ritchie Raquel P. , Ruger Katherine M. , Waarala Kirsten L. , Wilkins Carol A. 
Published: August 2022

Abstract
Background: Study objectives were to appraise the effectiveness of Zoom delivery versus live campus-based delivery of lectures in biochemistry and genetics courses and assess the integrity of remote versus campus administered exams. Methods: Participants were 601 students entering Michigan State University College of Osteopathic Medicine in 2019 or 2020. The former completed courses and exams on campus, while the latter completed courses online due to the COVID-19 pandemic. For the biochemistry and genetics courses, the same lecturers delivered the same content and used identical exam questions for assessments in 2019 and 2020. The investigators compared percent correct for each question in 2019 and 2020. Results: This study found 84/126 (~67%) of the questions yielded little difference (3% or less in % Correct) between live delivery and Zoom delivery. For questions whose % Correct index differed by 4% or more, Zoom delivery yielded a better performance for 16 questions (~13%), while 19 questions (~15%) showed live lectures performed better. Seven of the questions (~6%) had an identical mode of delivery in 2019 and 2020 (e.g. self-study exercise). These served as “control questions” for which equivalent student performance was expected. The 126 questions analyzed spanned a wide range in the % Correct index, from ~60% Correct to >90% Correct. Conclusions: The results suggest that Zoom and on-campus delivery of the content in biochemistry and genetics yielded similar achievement of course objectives. The high concordance, between 2019 and 2020, of the % Correct for individual questions also speaks to exam integrity including online proctoring.
What is the Impact of Light Curing Modes of High-Powered LED on Temperature rise in Primary Teeth Dentin: An In Vitro Study
Authors: Jabbour Obada , Alfares Reem 
Published: August 2022

Abstract
Background: Temperature rise in the pulp chamber is a severe stress that can cause irreversible damage to the pulp. The objective of this study was to compare the temperature rise under primary tooth dentin induced by a light emitting diode (LED) with different light curing modes.Methods: Sixty dentin discs of 0.5- 1- 1.5- and 2-mm thicknesses were prepared from human primary molars. The resin composite placed in a Teflon cavity was cured using a high-powered LED (Foshan JERRY Medical Apparatus CO., LTD, Foshan, China) for 20 s. The different modes tested in this study were standard mode, ramp mode, and pulse mode (n=5). Temperature was recorded using a k-type thermocouple in direct contact with the dentin disc. Temperature change data were subjected to analysis of variance (ANOVA) and Tukey's test.Results: The highest temperature rise was observed under a 0.5 mm thick dentin disc with standard mode (4.7 ± 0.42), whereas the lowest values were recorded with pulse mode under 2 mm thick dentin (2.5 ± 0.23). Pulse mode produced a significantly lower temperature rise than standard mode for all dentin thicknesses (P < 0.05). Ramp mode gave significantly lower values than standard mode in the 0.5 mm group (P < 0.05). For the standard and ramp modes, the 0.5 mm thick group exhibited a higher temperature rise than the 2 mm thick group (P < 0.05).Conclusions: Temperature rise related to dentin thickness and curing modes. The standard mode led to a significantly higher temperature rise under thinner dentin than the other modes. Pulse mode gave the lowest values. Thus, it is recommended for use in deep cavities. Clinical Significance: The temperature rise during polymerization of the resin composite with the high-powered LED appeared to be below 5.5 ℃. Hence, it appears to be safe for use in pediatric dentistry.
A Study of Land-Use Changes and Its Impacts on Flood Inundation in the Konkoure River Basin, Republic of Guinea.
Authors: Bah Alhassane , Zhang Hongbo , Luo Zhumei , Hu Jimin , Zhang Zulian , Xie Yang Lin , Yang Ting , Chen Guohong , Bah Alseny 
Published: August 2022

Abstract
This study evaluates the land-use change in the Konkoure River basin and its impact on flood inundation. The land-use changes were assessed using Landsat image (level 1) in August 2006 and August 2021. Land-use change assessment methods geographic information systems (GIS) and remote sensing were utilized. Thus, land use in Landsat imagery was identified using the NDVI, NDBI, and NDWI indices. We noticed that 32.16% of the total area became built-up areas, and 35.51% was converted to other land uses in Konkoure watershed. Konkoure's most significant change is that 29.50% of forest area transformed into built-up areas and other land uses. The changing impacts were assessed using satellite-based rain; specifically, GSMaP, which was used for input for the Rainfall-Runoff-Inundation (RRI) model. The RRI-based inundation of the Konkoure River Basin was compared to the MODIS extent. Due to the change in land use from forest land to built-up area, the infiltration rate reduced from 7.498mm/h to 5.33mm/h. As a result, runoff volumes surged by more than 100%, from 2146 m3/s to 4191.7 m3/s, and the flood inundation area grew from 129.43 km2 to 182.17 km2.
Mesenteric Teratoma in Adult Female: A Rare Case
Authors: Oropeza-Duarte César , García-Marín Gustavo Emmanuel , Monraz-Alvarez Daniel , Leonher-Ruezga Karla , Suárez-Velázquez Daniela , García-Morán Karla , García-Colunga María Fernanda , Torres Quitzia Libertad 
Published: August 2022

Abstract
Background: Mesenteric teratomas are considered rare intra-abdominal tumours with minimum clinical symptoms, which turn difficult their preoperative diagnosis. They represent a poorly studied pathology that has been established with 1 in 26,794 to 250,000 frequency of hospital admissions. It is not frequent to think about this kind of lesion in a preoperative period, and the symptoms it presents can be very ambiguous. Therefore, in this study we present a case of acute abdomen, in a 65-year-old Mexican woman, in which a mesenteric teratoma was obtained as a surgical finding. Case presentation: 65-year-old woman who presented a clinical picture of abdominal pain and distention, nausea and constipation, as well as absence of gas channeling in the last 24 hours. After 48 hours of conservative management, without favorable results and with a diagnosis of acute abdomen, surgery was entered to perform exploratory laparotomy and an intraoperative finding of mesenteric teratoma was made. Two ovoid specimens were extracted and sent to the pathology area, who confirms the diagnosis of mature cystic teratoma.Conclusions: Teratoma is commonly a germ cell tumour that originates in the gonads and is detected in women of reproductive age. This is extremely rare, with an estimated 21 cases reported to date. Despite the low frequency, it is suggested to it considered these teratomas in the differential diagnosis against other pathologies, especially if they do not show a very clear data.
Cost-Effectiveness of Immune Checkpoint Inhibition and Targeted Treatment in Combination as Adjuvant Treatment of Patient with BRAF-Mutant Advanced Melanoma
Authors: Li Sini , Wan Xiaomin , Peng LiuBao , Li YaMin , Li JianHe 
Published: August 2022

Abstract
Background: Immune checkpoint inhibitors (ICIs) and targeted treatments have improved the health outcomes of patients with advanced melanoma. However, due to the high cost of novel therapies, it is crucial to evaluate their value by considering both effectiveness and cost.OBJECTIVE To compare the cost-effectiveness of these novel agents (atezolizumab-vemurafenib-cobimetinib, vemurafenib-plus-cobimetinib, dabrafenib-plus-trametinib, and encorafenib-plus-binimetinib) for first-line treatment of metastatic melanoma with the BRAFV600 mutation.Methods: A patient-level model was developed to project the health outcomes of 4 strategies for patients with advanced melanoma. We estimated transition probabilities from the IMspire150 (ClinicalTrials.gov, NCT02908672), COMBI-AD (NCT01682083), and COLUMBUS (NCT01909453) trials using a parametric survival model. All health outcomes, including direct cost, quality-adjusted life-years (QALYs) and the incremental cost-effectiveness ratio (ICER), were estimated from the US payer perspective. Lifetime cost, QALYs, life-years (LYs), and ICERs were calculated. Univariable and probabilistic sensitivity analyses were performed to test model robustness, along with multiple scenario analyses.Results: Of the 4 competing strategies, atezolizumab-vemurafenib-cobimetinib produced the best health outcomes, and the vemurafenib-cobimetinib strategy was the least expensive option. Atezolizumab-vemurafenib-cobimetinib, dabrafenib-plus-trametinib, and vemurafenib-cobimetinib formed the cost-effective frontier, indicating that the ordered ICERs were $325113/QALYs for dabrafenib-plus-trametinib vs. vemurafenib-cobimetinib strategies and $2247500/QALYs for atezolizumab-vemurafenib-cobimetinib vs. dabrafenib-plus-trametinib strategies. Encorafenib-plus-binimetinib was dominated by the other 3 competing strategies. The drug price and first-line utility significantly influenced the model outcomes.Conclusion: For BRAF-mutant advanced melanoma, the vemurafenib-cobimetinib strategy could be considered the most cost-effective treatment at the willingness-to-pay threshold of $150,000.
Event-based finite-time quantized synchronization for discrete Markovian neural networks
Authors: Liu Caixia , Li Ying , Shi Yan , Zhang Yingqi 
Published: August 2022

Abstract
This paper is investigated with the robust finite-time synchronization of discrete-time Markovian jump neural networks with partially unknown transition probabilities. Firstly, a unified framework based on event-triggering approaches and quantization, a synchronization error model is first provided for discrete-time Markovian neural networks. Secondly, with the aid of Lyapunov-Krasovskii functional, sufficient conditions for the finite-time boundedness are deduced which can ensure synchronization of the system model, and the quantized finite-time controller and event-triggered parameters are co-designed so that Markovian neural networks are finite-time bounded by variable decoupled techniques. Finally, a simulation example is established to illustrate the availability of the presented methods.MSC Classification: 15A39 , 24D06 , 93B51 , 93D30 , 93E15
Screening key marker molecules of osteosarcoma using bioinformatics analysis technology
Authors: Xu Ruiqing , Wan Ningjun , Shi Jiandang 
Published: August 2022

Abstract
BACKGROUND
The most frequent primary bone tumor in children, adults, and elderly individuals over 60 years of age is osteosarcoma (OS), which is most commonly detected in the long bone epiphysis and has a poor prognosis and a high impairment rate. The precise etiology and underlying molecular pathways, however, remain unknown. Using bioinformatics approaches to evaluate the underlying biological mechanisms, this work attempted to discover differentially expressed genes (DEGs) in OS, implicated cell signaling pathways, and associated immune infiltration.
MATERIALS AND METHODS
The GSE14359 dataset's expression profiles were downloaded from the GEO database, which contains 20 samples, including 18 OS samples and 2 normal osteoblast control samples. Raw data were collected, DEGs were obtained, and bioinformatics was used to further analyze the data. The gene expression matrix was subjected to WGCNA-weighted gene co-expression network analysis using R (version 4.1.1) software, as well as gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of candidate genes. The STRING database was used to create protein-protein interaction (PPI) networks of candidate genes. Core gene network maps were created using the Cytoscape software. The R (version 4.1.1) software was used to rank key genes. Subsequently, plots of individual hub gene survival curves, expression and clinical correlation and promoter methylation and clinical correlation were produced via an online website (http://ualcan.path.uab.edu/). Finally, the infiltration of immune cells in OS was assessed using CIBERSORT.
RESULTS
A total of 625 DEGs were identified, of which 314 were up-regulated and 311 were down-regulated. Principal component analysis showed significant differences between the two tissues. WGCNA-weighted gene co-expression showed the highest absolute value of the MEgrey60 module, and a total of 247 genes were listed in the intersection of DEGs and MEgrey60 module genes taken.KEGG pathway analysis showed that these candidate genes mainly involved adherent spots, Rap1, PI3K-Akt, and MAPK, while GO pathway analysis mainly involved cellular processes such as osteogenesis, epithelial cell proliferation, osteoblast differentiation, and molecular functions such as growth factors and fibronectin binding. The 23 most closely related genes among the candidate genes were identified from the PPI network.
CONCLUSION
Our study shows that screening for DEGs, pathway enrichment and immune infiltration using bioinformatics analysis not only helps to understand the molecular mechanisms of OS occurrence but also facilitates us to better execute target gene interventions. However, this study still has limitations and subsequent clinical validation of the samples is needed.
The effect of strength training on women’s happiness and well-being: a systematic review
Authors: Pontes Glendha Bastos 
Published: August 2022

Abstract
Background: Despite the widespread health benefits of strength training, women are often discouraged to seek this practice due to limiting gender-constructed roles influenced by cultural ideations that resist exaggerated hypertrophy among women. The objectives of this systematic review are two-fold. Primarily, to access and summarize information from existing studies underscoring the effects of regular strength training practice on women’s well-being, published in the last 10 years. Second, to relate the findings of this study with the PERMA model of well-being from positive psychology. Methods: Two electronic databases were used in this review, namely, Google Scholar and PubMed. The inclusion criteria comprised papers published in English and dated between January 1, 2012, and May 15, 2022, yielding a total of 439 publications. Furthermore, studies were excluded if: no interventions were applied, the results did not focus on female participants, the study lacked variables related to well-being, and the study was not based on strength training. Upon screening for relevance and applicability of the studies based on the abovementioned criteria, 11 publications were selected, and the Cochrane Risk of Bias Tool (RoB 2.0) was applied to assess the risk of bias. Results: In total, 457 female participants from the 11 studies were included in this review. And seven studies presented positive effects of strength training on variables related to well-being, while three studies presented no significant changes. The remaining article did not present any significant changes in sense of coherence (SoC) and health-related quality of life (HRQoL); however, it found positive effects for hope, while no negative effects were observed. Discussion: Literature underscoring the benefits of strength training on women’s happiness is limited. Furthermore, studies that comprised only female participants are also limited, and largely characterized by variations in age, physical health, cultural context, and previous relationship with sports. Moreover, the effects of mental health and well-being are often not prioritized in research, resulting in study designs that have limited use among psychologists and other mental health professionals. Nevertheless, the current review showed that strength training exerts predominantly positive effects on women’s happiness. While some effects were neutral, no negative effects were found. Possible implications of the current paper refer to the stimuli of the prescription of a program of strength training for women aiming to improve overall well-being and to call attention to the need for more scientific research on the topic.
How good gender be identified from heart rate data? Evaluation using ALLSTAR Heart rate variability big data analysis
Authors: Kaneko Itaru , Hayano Junichiro , Yuda Emi 
Published: August 2022

Abstract
Objective: A small electrocardiograph and Holter electrocardiograph can record an electrocardiogram for 24 hours or more. We examined whether gender could be verified from such an electrocardiogram and, if possible, how accurate it would be.Results: Ten dimensional statistics were extracted from the heart rate data of more than 420,000 people, and gender identification was performed by various major identification methods. Lasso, linear regression, SVM, random forest, logistic regression, k-means, Elastic Net were compared. The best Accuracy was 0.638 for logistic regression. Although the discrimination results based on these statistics are statistically significant, it was confirmed that they are not accurate enough to determine the gender of an individual.