bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolomic response to collegiate football participation: Pre- and Post-season analysis
Authors: Vike Nicole L. , Bari Sumra , Stetsiv Khrystyna , Talavage Thomas M. , Nauman Eric A. , Papa Linda , Slobounov Semyon , Breiter Hans C. , Cornelis Marilyn C. 
Published: February 2022

AbstractContact sports participation has been shown to have both beneficial and detrimental effects on health, however little is known about the metabolic sequelae of these effects. We aimed to identify metabolite alterations across a collegiate American football season. Serum was collected from 23 male collegiate football athletes before the athletic season (Pre) and after the last game (Post). Samples underwent nontargeted metabolomic profiling and 1131 metabolites were included for univariate, pathway enrichment, and multivariate analyses. Significant metabolites were assessed against head acceleration events (HAEs). 200 metabolites changed from Pre to Post (P < 0.05 and Q < 0.05); 160 had known identity and mapped to one of 57 pre-defined biological pathways. There was significant enrichment of metabolites belonging to five pathways (P < 0.05): xanthine, fatty acid (acyl choline), medium chain fatty acid, primary bile acid, and glycolysis, gluconeogenesis, and pyruvate metabolism. A set of 12 metabolites was sufficient to discriminate Pre from Post status, and changes in 64 of the 200 metabolites were also associated with HAEs (P < 0.05). In summary, the identified metabolites, and candidate pathways, argue there are metabolic consequences of both physical training and head impacts with football participation. These findings additionally identify a potential set of objective biomarkers of repetitive head injury.
Effects of fatty acid metabolites on nocturia
Authors: Ihara Tatsuya , Shimura Hiroshi , Tsuchiya Sachiko , Kanda Mie , Kira Satoru , Sawada Norifumi , Takeda Masayuki , Mitsui Takahiko , Shigetomi Eiji , Shinozaki Yoichi , Koizumi Schuichi 
Published: February 2022

AbstractDysregulation of circadian rhythm can cause nocturia. Levels of fatty acid metabolites, such as palmitoylethanolamide (PEA), 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE), and 4-hydroxy-5E,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid (4-HDoHE), are higher in the serum of patients with nocturia; however, the reason remains unknown. Here, we investigated the circadian rhythm of fatty acid metabolites and their effect on voiding in mice. WT and Clock mutant (ClockΔ19/Δ19) mice, a model for nocturia with circadian rhythm disorder, were used. Levels of serum PEA, 9-HODE, and 4-HDoHEl were measured every 8 h using LC/MS. Voiding pattern was recorded using metabolic cages after administration of PEA, 9-HODE, and 4-HDoHE to WT mice. Levels of serum PEA and 9-HODE fluctuated with circadian rhythm in WT mice, which were lower during the light phase. In contrast, circadian PEA and 9-HODE level deteriorated or retreated in ClockΔ19/Δ19 mice. Levels of serum PEA, 9-HODE, and 4-HDoHE were higher in ClockΔ19/Δ19 than in WT mice. Voiding frequency increased in PEA- and 4-HDoHE-administered mice. Bladder capacity decreased in PEA-administered mice. The changes of these bladder functions in mice were similar to those in elderly humans with nocturia. These findings highlighted the novel effect of lipids on the pathology of nocturia. These may be used for development of biomarkers and better therapies for nocturia.
Evaluating the cost-effectiveness of a pre-exposure prophylaxis program for HIV prevention for men who have sex with men in Japan
Authors: Yamamoto Nao , Koizumi Yoshiki , Tsuzuki Shinya , Ejima Keisuke , Takano Misao , Iwami Shingo , Mizushima Daisuke , Oka Shinichi 
Published: February 2022

AbstractMen who have sex with men (MSM) have been disproportionally affected by the HIV epidemic in many countries, including Japan. Although pre-exposure prophylaxis (PrEP) is a strong prevention tool, it is not yet approved in Japan. A Markov model was developed to describe HIV infection and disease progression in an MSM cohort (N = 1000) in Japan receiving a PrEP program. The model was used to evaluate the cost-effectiveness of a PrEP program. HIV/AIDS treatment, screening, hospitalization due to AIDS, and PrEP were considered as costs and quality-adjusted life-years (QALYs) gained as utilities. Cost-effectiveness was assessed by comparing the incremental cost-effectiveness ratio (ICER) over a 30-year period against the willingness to pay (WTP) threshold. One-way sensitivity and probabilistic sensitivity analyses were performed. With 50% PrEP coverage, the PrEP program became dominant against the program without PrEP, using a threshold of 5.0 million JPY/QALY (45,455 USD). The probabilistic sensitivity analysis revealed that the PrEP program was dominant or at least cost-effective in most cases of 10,000 simulations. Therefore, preparing cheaper PrEP pills, which results in PrEP being dominant or ICER being lower than the WTP threshold, is important to make the program cost-effective. Introduction of PrEP to an MSM cohort in Japan would be cost-effective over a 30-year time horizon.
The impact of glucose tolerance state on seropositivity rate after hepatitis B vaccination
Authors: Chang Villacreses Maria Mercedes , Karnchanasorn Rudruidee , Ou Horng-Yih , Samoa Raynald , Chuang Lee-Ming , Chiu Ken C. 
Published: February 2022

AbstractImmunization is recommended for people with diabetes mellitus (DM), but little information is available on their seropositivity rates. To determine the impact of glucose tolerance state on seropositivity rate after hepatitis B vaccination, we included 7645 adult participants from the National Health and Nutrition Examination Survey 2005–2016 who reported three doses of hepatitis B vaccine and were seropositive for anti-hepatitis B surface antibody (≥ 12.0 mIU/mL), after exclusion of those positive for anti-hepatitis B core antibody and/or hepatitis B surface antigen. We classified the states of glucose tolerance as normal glucose tolerance (NGT, 61.68%), abnormal glucose tolerance (AGT, 26.02%), or DM (13.30%). We observed a stepwise decline in hepatitis B seropositivity rate from NGT (53.64%) to AGT (45.52%) to DM (28.84%) (P < 0.0001). We confirmed these results after standardization for age and BMI (P < 0.0001 for all subgroup analyses) and in subgroup analyses by gender and racial/ethnic group. Dysregulated glucose metabolism is associated with a decreased seropositivity rate after hepatitis B vaccination. Our observations suggest that regular follow-up screening for anti-hepatitis B surface antibody, with additional booster vaccination as necessary, is especially important in patients with DM. Whether a similar phenomenon exits for other vaccines, especially COVID-19, remains to be investigated.
Simultaneous binding of heme and Cu with amyloid β peptides: active site and reactivities
Authors: Nath Arnab Kumar , Dey Somdatta Ghosh 
Published: February 2022

Active site environment of simultaneously bound heme and Cu with amyloid β (Aβ) peptides and its reactivities with small molecues like O2, NO and NO2- associated with Alzheimer's disease.
eHealth Education and Support for Pediatric Hearing Aid Management: Parent Goals, Questions, and Challenges
Authors: Nichols Natalie , Muñoz Karen , San Miguel Guadalupe G. , Twohig Michael P. 
Published: February 2022

Purpose:
The purpose of this study was to investigate parent goals, questions, and challenges that emerged during coaching phone calls in an eHealth program designed to provide education and support for hearing aid management.

Method:
Coaching phone calls were audio-recorded, transcribed, and qualitatively analyzed for emergent themes within the categories of goals, questions, and challenges.

Results:
Emergent themes revealed that parent goals were focused on self-efficacy, routines, device care, and child development. Emergent themes for questions revealed that parents asked questions related to the device care, audiology appointments, confirmation of learning, and child development. For challenges, emergent themes revealed parents' own struggles (e.g., with emotions), issues related to working with their audiologist, child factors, and anticipated challenges.

Conclusions:
The eHealth intervention allowed parents to raise questions and discuss their challenges in a supportive environment. Supportive accountability helped participants identify and address barriers to hearing aid management based on their priorities and current challenges. Providing supplemental learning support, in addition to routine audiology visits, can help parents develop more effective hearing aid management routines.
Reactions of α-Phenylglyoxylic Acids with ortho-Functionalized Anilines in Deep Eutectic Solvents: Selective Syntheses of 3-Aryl-2H-benzo[b][1,4]oxazin-2-ones, 2-Arylbenzothiazoles, and 3-Arylquinoxalin-2(1H)-ones
Authors: Xie Zongbo , Le Zhanggao , Jiang Guofang , Chen Guoqing , Yang Jiangnan , Li Hongxia , Chen Zhongsheng 
Published: February 2022

Abstractα-Phenylglyoxylic acid is a novel cyclization reagent. In this study, three cyclization products were synthesized by the reaction of α-phenylglyoxylic acids with ortho-functionalized anilines in deep eutectic solvents (DES). The five-membered-ring-formation products, the 2-arylbenzothiazoles, with a highest yield of 88%, were obtained by the reaction between 0.30 mmol of an o-aminothiophenol and 0.30 mmol of an α-phenylglyoxylic acid in choline chloride (ChCl)/d-(–)-tartaric acid DES at 60 °C for 0.5 h. The six-membered-ring-formation products, 3-aryl-2H-benzo[b][1,4]oxazin-2-one derivatives, were obtained in yields up to 99% by the reaction between 0.30 mmol of an o-aminophenol and 0.60 mmol of an α-phenylglyoxylic acid in ChCl/urea DES at 80 °C for 2.0 h. In the reaction between 0.30 mmol of o-phenylenediamine and 0.45 mmol of an α-phenylglyoxylic acid in ChCl/anhydrous tin(II) chloride DES at 70 °C for 1.5 h, the six-membered-ring-formation products, 3-arylquinoxalin-2(1H)-one derivatives, were synthesized, with a highest yield of 96%. This cyclization reaction occurred without the addition of other catalysts, and the title compounds were obtained with good yields under mild conditions.
Determinants of Patient Refusal of Postoperative Radiation Therapy in Sinonasal Squamous Cell Carcinoma
Authors: Kshirsagar Rijul S. , Eide Jacob G. , Prasad Aman , Carey Ryan M. , Rajasekaran Karthik , Brant Jason A. , Newman Jason G. , Palmer James N. , Adappa Nithin D. 
Published: February 2022

Abstract
Objectives Although adjuvant radiotherapy may be indicated in patients with sinonasal squamous cell carcinoma (SNSCC) following primary surgery, some patients choose to forgo recommended postoperative radiation therapy (PORT). This study aimed to elucidate factors associated with patient refusal of recommended PORT in SNSCC and examine overall survival.
Methods Retrospective analysis of patients with SNSCC treated with primary surgery from the National Cancer Database diagnosed between 2004 and 2016. A multivariable logistic regression model was created to determine the association between clinical or demographic covariates and likelihood of PORT refusal. Unadjusted Kaplan–Meier estimates, log-rank tests, and a multivariable Cox proportional hazard model were used to assess overall survival.
Results A total of 2,231 patients were included in the final analysis, of which 1,456 (65.3%) were males and 73 (3.3%) refused recommended PORT. Patients older than 74 years old were more likely to refuse PORT than those younger than 54 (odds ratio [OR] 3.43, 95% confidence interval [CI]: 1.84–6.62). Median survival among the entire cohort, those who received recommended PORT, and those who refused PORT was 83.0 months (95% CI: 74.6–97.1), 83.0 months (95% CI: 74.9–98.2), and 63.6 months (95% CI: 37.3–101.4), respectively. Refusal of PORT was not associated with overall survival (hazard ratio: 0.99, 95% CI: 0.69–1.42).
Conclusions PORT refusal in patients with SNSCC is rare and was found to be associated with several patient factors. The decision to forgo PORT is not independently associated with overall survival in this cohort. Further study is required to determine the clinical implications of these findings as the treatment decisions are complex.
Histology of the Porous Oculomotorius: Relevance to Anterior Skull Base Approaches
Authors: Rennert Robert C. , Goodwill Vanessa , Steinberg Jeffrey A. , Fukushima Takanori , Day John D. , Khalessi Alexander A. , Levy Michael L. 
Published: February 2022

Abstract
Objective Mobilization of cranial nerve III (CNIII) at its dural entry site is commonly described to avoid damage from stretching during approaches to the parasellar, infrachiasmatic, posterior clinoid, and cavernous sinus regions. The histologic relationships of CNIII as it traverses the dura, and the associated surgical implications are nonetheless poorly described. We herein assess the histology of the CNIII–dura interface as it relates to surgical mobilization of the nerve.
Methods A fronto-orbitozygomatic temporopolar approach was performed on six adult cadaveric specimens. The CNIII–dural entry site was resected and histologically processed. The nerve–tissue planes were assessed by a neuropathologist.
Results Histologic analysis demonstrated that CNIII remained separate from the dura within the oculomotor cistern (porous oculomotorius up to the oculomotor foramen). Fusion of the epineurium of CNIII and the connective tissue of the dura was seen at the level of the foramen, with no clear histologic plane identified between these structures.
Conclusion CNIII may be directly mobilized within the oculomotor cistern, while dissections of CNIII distal to the oculomotor foramen should maintain a thin layer of connective tissue on the nerve.
Fatigue Resistance of Cast-on Implant Abutment Fabricated with Three Different Alloys
Authors: Puengpaiboon Usanee , Didron Pavinee Padipatvuthikul 
Published: February 2022

Abstract
Objectives This study aimed to evaluate fatigue resistance of cast-on implant abutment using three alloys.
Materials and Methods Forty specimens of implant-supported crowns were prepared; Group 1 (TA) stock titanium abutments, Group 2 (GS) abutment cast with 40% gold alloy, Group 3 (GP) abutment cast with palladium alloy, and Group 4 (CN) abutment cast with nickel–chromium alloy. Specimens were cyclic loaded at 20 Hz, starting from 200 N (5,000 cycles), followed by stepwise loading of 400, 600, 800, 1,000, 1,200, 1,400, 1,600, and 1,800 N (30,000 cycles/step). Specimens were loaded until failure or reached 245,000 cycles.
Statistical Analysis The withstand cycles were analyzed using one-way analysis of variance and Weibull survival analysis. Fracture surfaces were examined using scanning electron microscopy.
Results The results of withstand cycles were TA (189,883 ± 22,734), GS (195,028 ± 22,371), GP (187,662 ± 22,555), and CN (200,350 ± 30,851). The statistical analysis showed no significant difference between the groups (p = 0.673).
Conclusion Although CN has higher Weibull characteristic strength which means greater durability, its lower Weibull modulus demonstrated less structural reliability. Consistent failures at implant fixture level were also found in CN group.
Revealing the quasiparticle electronic and excitonic nature in cubic, tetragonal, and hexagonal phases of FAPbI3
Authors: Muhammad Zeeshan , Liu Peitao , Ahmad Rashid , Jalali-Asadabadi Saeid , Franchini Cesare , Ahmad Iftikhar 
Published: February 2022

The development of three-dimensional (3D) hybrid organic–inorganic perovskites has sparked much interest because of their rich light-harvesting capabilities in solar cells. However, the understanding of the electronic and optical properties, particularly the excitonic shifts upon structural phase transition with temperature in these materials, is not fully clear. Here, we report the accurate description of electronic and optical properties of mostly studied FAPbI3 across the cubic–tetragonal–hexagonal phases, using the relativistic GW method and Bethe–Salpeter Equation (BSE), including the spin–orbit coupling effects. Our GW calculations reveal that the bandgap values vary from 1.47 to 3.54 eV from the room temperature cubic phase to the low temperature hexagonal phase. Our optical analysis shows that excitonic peaks are blue-shifted, and exciton binding energies estimated by the model BSE approach increase from 74 to 567 meV going from the cubic to hexagonal phases. Our results may have important impacts on the practical uptake of hybrid perovskite based solar cells under different climatic conditions.
Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice
Authors: Wang Yuexia , Shilagardi Khurts , Hsu Trunee , Odinammadu Kamsi O. , Maruyama Takamitsu , Wu Wei , Lin Chyuan-Sheng , Damoci Christopher B. , Spear Eric D. , Shin Ji-Yeon , Hsu Wei , Michaelis Susan , Worman Howard J. 
Published: February 2022

SignificanceThe zinc metalloprotease ZMPSTE24 removes the last 15 amino acids of prelamin A, including a farnesylated cysteine, to produce mature lamin A. The premature aging disorder Hutchinson–Gilford progeria syndrome is caused by a permanently farnesylated prelamin A variant lacking the ZMPSTE24 cleavage site. ZMPSTE24 loss of function leads to the accumulation of farnesylated prelamin A and causes progeroid disorders. Some studies have implicated prelamin A in physiological aging. We describe mice with an amino acid substitution in prelamin A that blocks the ZMPSTE24-catalyzed cleavage. These mice develop progeroid phenotypes but, in contrast to those modeling Hutchinson–Gilford progeria syndrome or ZMPSTE24 deficiency, have near-normal lifespans, thus providing a model to study the effects of farnesylated prelamin A during aging.
zMADM (zebrafish mosaic analysis with double markers) for single-cell gene knockout and dual-lineage tracing
Authors: Xu Bing , Kucenas Sarah , Zong Hui 
Published: February 2022

Significance
The transparent body of the larval zebrafish makes it an excellent vertebrate model for studying both developmental and disease processes in real time. However, the difficulty of genetic manipulation of zebrafish has greatly hindered its full power in biological studies. To overcome these hurdles, we establish a genetic system called zebrafish mosaic analysis with double markers (zMADM). zMADM has three unique advantages: First, it can achieve conditional knockout of genes residing on the zMADM-bearing chromosome without the need to generate floxed alleles, which is highly challenging and time consuming in the zebrafish; second, it allows the fate mapping of two sibling lineages; and third, it enables cell autonomous phenotypic analysis at single-cell resolution with sibling wild-type cells as internal control.
Gone unexpectedly
Authors: Cruschina Silvio 
Published: February 2022

Abstract
In this paper, I discuss a periphrastic construction involving the verb go in Sicilian that is used to express surprise and unexpectedness with respect to a past event. I show that the special meaning and function of this structure is best accounted for by postulating that in this construction the verb go is now a functional verb associated with a mirative conventional implicature. In this use, the construction is grammatically in the present tense, but is used within a narrative context to foreground an unexpected or surprising event that happened in the past. To account for the present-tense morphology, I propose that the conversational backgrounds – and in particular the ordering source defining the set of expectations of the conversation participants – can be indexed to the present time. I finally explore the hypothesis that the mirative use of this construction can shed light on the development of the Catalan go-past.
Pseudo-coordination and ellipsis
Authors: Mendes Gesoel , Ruda Marta 
Published: February 2022

Abstract
In this paper, we offer some comments about the syntax of pseudo-coordination in colloquial registers of Brazilian Portuguese and Polish. Focusing on V1-take (and) pseudo-coordination, we suggest that, in both of them, V1-take (and) belongs to the expressive realm of language and we analyze V1-take (and) as an appositive element adjoined to vP in the extended projection of V2. In addition to the meaning of the structure, evidence for the expressive nature of V1-take (and) comes from the fact that it can be ignored for ellipsis purposes in contexts such as verb-echo answers, polarity contrast, verb-doubling and VP-topicalization. Evidence for the positioning of V1-take (and) at the vP edge is provided by distributional patterns, including the placement of adverbs and sentential negation with respect to V1-take (and) and V2. We propose that two minimally different structures are available for pseudo-coordination, depending on whether a coordinator accompanies V1.
Pseudo-coordination, pseudo-subordination, and para-hypotaxis
Authors: Edzard Lutz 
Published: February 2022

Abstract
The phenomena of pseudo-coordination and, to a lesser degree, pseudo-subordination have been recognized to play an important role in Semitics linguistics, notably in the realm of converb (gerund) and serial verb constructions, albeit under different scholarly labeling. As the distinction between coordinated (paratactic) and subordinated (hypotactic) structures is often blurred in this context, this paper additionally refers to the concept of “para-hypotaxis”. As will be shown, this choice of terminology, further elaborating on a basic model proposed by Yuasa and Sadock (2002: 91), is useful to describe an analyze a number of phenomena in the domain of complex predicates, in both ancient and modern Semitic languages.
Ambiguities in Japanese pseudo-coordination and its dialectal variation
Authors: Shimada Masaharu , Nagano Akiko 
Published: February 2022

Abstract
This paper addresses Japanese pseudo-coordination containing an existential verb by focusing on the two types of existential verbs, one taking an animate subject and the other taking an inanimate subject. Though both can form a pseudo-coordination expression, one is two-way ambiguous in aspectual interpretation, and the other is not. Moreover, dialectal variation is observed. This paper attempts to explain the difference between the two interpretations of Japanese pseudo-coordination and assigns a different structure to each interpretation. More specifically, in one interpretation, existential verbs are truly existential verbs of a lexical category, and in the other interpretation, they are functional categories. Based on this analysis, dialectal variation is also explained based on the notion of externalization.
Three German discourse particles as speech act modifiers
Authors: Schneider Johannes 
Published: February 2022

Abstract
This work attempts to reduce the properties of three German discourse particles (DPs), ja,
nicht and etwa, to the basic building blocks of a formal discourse model (Farkas & Bruce 2010). We propose a definition of DPs as speech act
modifiers that restricts the space of allowed variation of their meanings, arguing against previous approaches in
terms of speaker attitudes. Speech acts modified by ja update the Common Ground
(CG) directly; previous characterizations of the epistemic status of the proposition arise as
descriptions of common justifications for such an imposed CG update. Etwa and
nicht turn open polar questions with two default resolutions into questions with only one
unmarked resolution; epistemic or bouletic attitudes arise as frequent connotations.