bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanistic Insight and Possible Mechanism of Seizure in Covid-19: The
Nuances and Focal Points
Authors: Al-Kuraishy Hayder M. , Al-Gareeb Ali I. , Rauf Abdur , Alhumaydhi Fahad A. , Kujawska Małgorzata , El-Saber Batiha Gaber 
Published: May 2022

Abstract:
Coronavirus disease 2019 (COVID-19) is a primary respiratory disease with an alarming
impact worldwide. COVID-19 is caused by severe acute respiratory syndrome coronavirus type 2
(SARS-CoV-2) and presents various neurological symptoms, including seizures. SARS-CoV-2 shows
neuroinvasive and neurotropic capabilities through a neuronal angiotensin-converting enzyme 2
(ACE2), which is also highly expressed in both neuronal and glial cells. Therefore, SARS-CoV-2 can
trigger neuroinflammation and neuronal hyperexcitability, increasing the risk of seizures. Olfactory
neurons could be an exceptional neuronal pathway for the neuroinvasion of respiratory viruses to access
the central nervous system (CNS) from the nasal cavity, leading to neuronal injury and neuroinflammation.
Although neuronal ACE2 has been widely studied, other receptors for SARS-CoV-2 in
the brain have been proposed to mediate viral-neuronal interactions with subsequent neurological
squeals. Thus, the objective of the present critical review was to find the association and mechanistic
insight between COVID-19 and the risk of seizures.
Pericyte control of blood flow in intraocular islet grafts impacts glucose homeostasis in mice
Authors: Tamayo Alejandro , Gonçalves Luciana , Rodriguez-Diaz Rayner , Pereira Elizabeth , Canales Melissa , Caicedo Alejandro , Almaça Joana 
Published: May 2022

<p> </p>
<p>The pancreatic islet depends on blood supply to efficiently sense plasma glucose levels and deliver insulin and glucagon into the circulation. Long thought to be passive conduits of nutrients and hormones, islet capillaries were recently found to be densely covered with contractile pericytes with the capacity to locally control blood flow. Here we determined the contribution of pericyte regulation of islet blood flow to plasma insulin and glucagon levels and glycemia. Selective optogenetic activation of pericytes in intraocular islet grafts contracted capillaries and diminished blood flow. In awake mice, acute light-induced stimulation of islet pericytes decreased insulin and increased glucagon plasma levels, producing hyperglycemic effects. Interestingly, pericytes are the targets of sympathetic nerves in the islet, suggesting that sympathetic control of hormone secretion may occur in part by modulating pericyte activity and blood flow. Indeed, <em>in vivo</em> activation of pericytes with the sympathetic agonist phenylephrine decreased blood flow in mouse islet grafts, lowered plasma insulin levels and increased glycemia. We further show that islet pericytes and blood vessels in living human pancreas slices responded to sympathetic input. Our findings indicate that pericytes mediate vascular responses in the islet that are required for adequate hormone secretion and glucose homeostasis. Vascular and neuronal alterations that are commonly seen in the islets of people with diabetes may impair regulation of islet blood flow and thus precipitate islet dysfunction.</p>
Risk Level of Design and Procurement Factors Causing Construction Waste Generation
Authors: Bachayo A. , Memon A. H. , Hussain M. , Rahman I. A. , Ahmed S. J. 
Published: May 2022

AbstractConstruction waste is a global concern among the practitioners and has got attention of the researchers for many years. This issue is serious in construction industry of Pakistan also and various researchers have contributed in addressing it. This paper identified design and procurement related factors and assessed their risk level in causing construction waste. Data was collected through questionnaire survey amongst the practitioners from client consultants and contractors working on construction projects in Karachi and Hyderabad division of the Sind province. A total of 72 completed questionnaire forms were analysed and the results shows that 8 of the 20 factors are highly important factors and fall in the red zone of the risk matrix. It was also observed that last minute client requirements is reported as most important factor in design related issues while “items not in compliance with specification” is the most risk factor in the category of the procurement. Besides these, “last minute client requirements” and “Mistakes in quantity surveys” are the key factors which have significant effect on project cost. The findings of this study will be helpful for the practitioner to improve design and procurement quality for controlling the waste generation.
Static Parametric Stress-Strain Analysis for Asphaltic Concrete Core of Rockfill Dams
Authors: Shiravi Shahram 
Published: May 2022

Abstract
This study was conducted to investigate the effect of variations in the asphaltic concrete core Rockfill dam geometric parameters on the core behavior at different upper, middle, and lower points under two-dimensional static stress-strain analysis. The mentioned analysis was performed using SIGMA/W software. In the modeling and analysis process, the geometry of a large number of dams constructed around the world was studied and many numerical models with variations in eight classes of height, three dams upstream/downstream slope modes, and three different asphaltic core positions and thicknesses on a rigid foundation were created and analyzed. In addition, for each of the above models, four dam operation stages including “End of Construction”, “Full Reservoir”, “Half-Full Reservoir”, and “Rapid Drawdown” were considered. The results show, in four different stages of construction and impounding and three different slope modes, the maximum stress as well as horizontal and vertical displacements at the upper, middle, and lower points of the core increase with increasing height. In all models, increasing upstream and downstream slopes results in an increase in the amount of vertical displacement for all construction and impounding stages at the upper, middle, and lower points of the core. In the middle and lower points of the core, with increasing height, the amount of deviatoric stress increases for all construction and impounding conditions. In addition, for all operation cases, the maximum strain increases in all points of the vertical and tilted cores as the core thickness increases. Additional results are presented in the next sections.
Regime of Contraventions and Sanctions Related to Vat Tax Declarations
Authors: Boiţă Marius , Dumiter Florin Cornel , Ajtay Eduard 
Published: May 2022

Abstract
In order to better collect taxes and combat fraud and tax evasion by strengthening the national legislative framework, a number of regulations and reports have been put in place for monitoring the declaration of all economic operations between partners in a regulated free market. The provisions adopted in the field of taxation in conjunction with the accounting report provided, respectively reported by the entities to the tax authorities, are applied for the correct assessment of their activity in order to combat the practices of tax avoidance, tax fraud, and tax evasion. This study does not analyze the fiscal policy as a whole, this paper addresses the regime of contraventions and sanctions, as well as the repercussions of non-declaration or incomplete or erroneous declaration of the Recapitulative Statements on intra-Community supplies/acquisitions/services (code D390) and Informative declarations on deliveries/services and purchases made in the national territory (code 394), related to value-added tax.
Competencies of Graduates – An Industry Expectation
Authors: Czerwińska-Lubszczyk Agnieszka , Grebski Michalene , Jagoda-Sobalak Dominika 
Published: May 2022

Abstract
Changes in the environment of industry may affect the expectations related to the competencies of the employees. Changes to the education system and curricula may be required. The main purpose of this research paper was to analyze the expectations of the industries related to competencies of graduates of engineering programs. The paper presents preliminary research. The survey was conducted at twenty-eight companies within the area of technical university in Poland. Based on the survey, data was collected related to the level of preparation of engineering graduates as well as the industry expectations related to the preparation of engineering graduates. This was done for the purpose of determining the gap between industry expectations and the level of preparation of the engineering graduates. Enterprises expect a wide range of competences from engineering graduates. The most important areas of competence included soft competences and practical knowledge and skills. The biggest gap between industry expectation and graduate’s preparation are the soft skills. Recommendations were suggested which would be incorporated in the engineering curriculum for the purpose of continuous quality improvement.
Efficient Practices of Cognitive Technology Application for Smart Manufacturing
Authors: Sira Mariya 
Published: May 2022

Abstract
Cognitive manufacturing (CM) provides for the merging of sensor-based information, advanced analytics, and cognitive technologies, mainly machine learning in the context of Industry 4.0. Manufacturers apply cognitive technologies to review current business metrics, solve essential business problems, generate new value in their manufacturing data and improve quality. The article investigates four powerful applications for cognitive manufacturing and their influence on a company`s maintenance. The study aims to observe kinds of cognitive technology applications for smart manufacturing, distinguish their prospective gains for manufacturers and provide successful examples of their adoption. The analysis is based on the literature and report review. Assessment of the cases of technology adoption proves that cognitive manufacturing provides both enhanced knowledge management and helps organizations improve fundamental business measurements, such as productivity, product reliability, quality, safety, and yield while reducing downtime and lowering costs.
Sehnsucht as Signpost: The Autobiographical Impulse of C. S. Lewis
Authors: Lazo Andrew 
Published: May 2022

AbstractFor half a century, readers of C. S. Lewis had only two problematic and at times obscure spiritual autobiographies (The Pilgrim’s RegressandSurprised by Joy) to use in attempts to understand Lewis’s journey to faith through what he called Joy, Sehnsucht, or longing. Both books, though important and full of key insights, in some ways hid more than they revealed. Recent discoveries, however, have widened the arc of autobiography. Lewis’s landmark pre-Christian account of his conversion to theism, ‘Early Prose Joy’, published in 2013, monumentally widened and deepened our understanding of Lewis’s spiritual journey to faith. And the fragmentary poem ‘I Will Write Down the Portion that I Understand’ also adds significant insight, at least into Lewis’s composition process of grappling with conversion. Insightful recent scholarship by Alister McGrath suggests widening the scope of what we consider spiritual autobiography in Lewis to includeA Grief Observed; this idea opens the door to a broader view of how autobiography functions both in Lewis’s compositional life and in the categorization of his writings. This essay accepts that invitation, finding clear autobiographical efforts to capture the role of Joy in Lewis’s early poetry, includingDymer, and in his late novelTill We Have Faces. That last book, written with soon-to-be-wife Joy Davidman, serves crucially to change the focus of Lewis’s spiritual autobiographies from Joy to love. By thus expanding and exploring Lewis’s autobiographical arc, this essay brings to light an almost teleological understanding of love and the central theme of Lewis’s life and work.
Le discours journalistique : entre discours historique et fiction. Vers une sémiotique de l’événement
Authors: Lozano Hernández Jorge 
Published: May 2022

Une typologie des discours pourrait situer le discours journalistique entre l’historique et le fictionnel. En considérant sa proximité et sa distance par rapport à ces deux types de discours, nous pourrions discuter de la construction de l’« événement », compris comme une configuration discursive. De nos jours, le discours journalistique peut être considéré comme prédominant dans l’histoire du présent (Zeitgeschichte). Un bon exemple des stratégies discursives dans chacun d’eux – histoire et fiction – est fourni par le cas référentiel de Wikileaks.
L’Adresse lyrique
Authors: Culler Jonathan 
Published: May 2022

La structure fondamentale de la poésie lyrique serait l’adresse triangulée (triangulated address): le lecteur donne voix à un discours qui s’adresse aux lecteurs par l’intermédiaire d’un tiers – quelqu’un ou quelque chose qui est adressé. La version la plus frappante de ce phénomène – figure qui résume tout ce qu’il y a de plus prétentieux et de mystificateur dans la poésie lyrique – serait la figure vatique de l’apostrophe: à savoir, l’interpellation d’un interlocuteur fictif (une urne, un oiseau, la Mort, la Beauté). L’adresse directe faite au lecteur est assez rare, et comporte souvent ce qu’on pourrait appeler un «vous flou» qui désigne le lecteur, ou tout le monde, ou encore le poète lui ou elle-même. C’est l’adresse lyrique qui fait du poème un événement.
Mots-clés: ADRESSE. APOSTROPHE. EXPRESSION. INVOCATION. TRIANGULATION.
Optimizing Performance Asphalt Concrete Hot Rolled Sheet– Wearing Course (HRS-WC) Using Chitosan Powder
Authors: Caroline Jenny , Kusuma Maritha Nilam 
Published: May 2022

Road quality is also affected by temperature and weather, leading to surface pavement deformation. It is necessary to improve the quality of the road pavement so that the quality of the road becomes more durable and stable. Hot Rolled Sheet – Wearing Course (HRS-WC) is flexible and has high durability. The natural mineral has been used as the filler for pavement construction. However, further research is necessary to obtain alternative and more sustainable materials. This study will discuss portland cement filler as a reference to compare filler replacement with chitosan powder (shellfish) based on the general specifications of the 2018 highway revision 3 division 6. Chitosan powder contains calcium oxide of 3.04% and silica oxide of 17.98%, which are similar to cement fillers. The composition of chitosan powder are 100%: 0%, 50%: 50%, 25%: 75%, and 0%: 100%. performance analysis is done through the marshall test. The results showed that the comparison of the use of the best chitosan powder was at the asphalt content of 7.3 with 50% : 50% with a marshall test value of 993.4 kg, flow 3.20 %, VMA 18.36%, VFB 72.01%, VIM 5.14, MQ 301.440 kg/mm. From the result which meets the requirement, the filler has shown quality improvement as an additional mixture according to (SNI 03-6723-2002). Hence still not optimal to replace portland cement because, from the value of the marshall test, portland cement has a higher marshall value than chitosan.
Perbandingan Jumlah Trombosit Pada Sampel Darah 3 ML, 2 ML, & 1 ML Dengan Antikoagulan K2EDTA Setelah Ditunda 4 Jam Di RSUD. Dr. H. Abdul Moeloek Bandar Lampung
Authors: Syuhada Syuhada , Izzudin Abdurrahman , Triwahyuni Tusy , Putri Bella Tania 
Published: May 2022

ABSTRACT Insufficient sample volume and delay can increase blood clotting; besides can cause platelets aggregation (stick to one another). Objectives: to determine whether there is a difference between the results of the hematology test of the platelet count in the volume of 3 ml, 2 ml, and 1 ml blood samples with K2EDTA anticoagulant after being postponed 4 hours. This study used an observational analytic method with a cross sectional design. The mean results of the platelet count in 1 ml and 2 ml of blood volume in the K2EDTA vacutaier tube which are postponed for 4 hours are higher than the platelet count in 3 ml of blood volume. Conclusion: There is no significant difference in the number of platelets in 3 ml, 2 ml, and 1 ml blood samples in the K2EDTA vacutainer tube after being postponed 4 hours. Key words: Hematology Test, Blood Volume, Postponed 4 Hours. ABSTRAK Volume sampel yang kurang dan penundaan dapat meningkatkan pembekuan darah dan menyebabkan trombosit mengalami agregasi (menempel dengan yang lainnya). Tujuan mengetahui apakah terdapat perbedaan antara hasil pemeriksaan hematologi jumlah trombosit pada volume sampel darah 3 ml, 2 ml, dan 1 ml dengan antikoagulan K2EDTA setelah ditunda 4 Jam pada orang sehat. Penelitian ini menggunakan metode analitik observasional dengan desain cross sectional. Hasil: Hasil rerata jumlah trombosit pada volume darah 1 ml dan 2 ml dalam tabung vacutaier K2EDTA yang ditunda selama 4 jam lebih tinggi dibandingkan dengan jumlah trombosit pada volume darah 3 ml. Tidak terdapat perbedaan bermakna jumlah terombosit pada sampel darah 3 ml, 2 ml, dan 1 ml pada tabung vacutainer K2EDTA setelah ditunda 4 jam. Kata Kunci : Pemeriksaan Hematologi, Volume Darah, Ditunda 4 Jam.
Top Five Indications of Hospital Admission of Infants
Authors: Uddin Md Jalal , Sultana Kawsar , Baidya Chinmoy , Akhter Nahida 
Published: May 2022

Background : Infants are at increased risk of morbidity and mortality. So, it is necessary for clinicians to properly place judgement on if an infant requires hospital admission. However, there is a lack of data on which diseases frequently need hospitalization in infancy. Hence the aim of this study was to provide a comprehensive description of infants requiring admissions to healthcare facilities.
Materials and methods : This was a cross-sectional study conducted at the outpatient department of a tertiary level hospital. Hundred infants between 1 month to 12 months of age, who were advised for hospitalization following a provisional diagnosis by an expert clinician were enrolled as study subjects. Their details were obtained from caregivers during their visit and the results were analyzed manually.
Results : The mean age of infants was 5.4±3.7 months with 2-month-old being the most common age group. The male: female ratio was 1.6:1 while the ratio forurban vs rural settings was 2.2:1. The most common religion was Islam (87%) followed by Hinduism (12%) and then Buddhism (1%). The most common diagnosis of study subjects in descending order of frequency were acute respiratory infection (46%) acute watery diarrhea (34%) burn and scald injury (13%) congenital disorders (10%) and late onset neonatal sepsis (8%).
Conclusion : Most common indicators requiring hospital admissions among infants are acute respiratory infection, acute watery diarrhea, burn and scald injury, congenital disorders and late onset neonatal sepsis. Further study needs to be done to look for seasonal variation and variation between neonates and other under-5 age group children.
Chatt Maa Shi Hosp Med Coll J; Vol.21 (1); January 2022; Page 3-6
An Analysis of the Referral Pattern of Urgent MRI in an Acute Unit
Authors: Chowdhury Jamil Haider 
Published: May 2022

Background : Urgent MRI (Magnetic Resonance Imaging) in clinical management is quite often required in the modern hospitals. In many cases, it may be needed for emergency patients and may save a valuable life. A few previous papers show MRI provision needs to be improved and many clinical situations need urgent MRI for management. This project was done with the objective to explore the range of urgent applications of MRI and aim to provide information supporting development of MRI service with the null hypothesis: "there is no need to introduce on call service for urgent MRI”.
Materials and methods: This thesis explored the applications of MRI as urgent investigations both retrospectively and prospectively in the busy MRI unit of the John Radcliffe Hospital, Oxford, UK, from 2004 to 2005.To assess the necessity of introducing an on-call service in the unit, a null hypothesis was developed: "There is no need to introduce on call service for urgent MRI”. To test the hypothesis, patients’ records were analysed to observe the effect in clinical management of MRI carried out as an urgent basis.
Results: The results explored the demographic trend, common examination areas, types of indications and the nature of MRI reports among the urgent patient referrals. The retrospective and prospective results showed similarity between the two years’ practices. The results of clinical effect of urgent MRI were found to be positive in the majority cases and the null hypothesis was rejected.
Conclusion: Overall, the thesis argues that the urgent MRI is not being carried out sufficiently in comparison to routine MRI, although urgent MRI has a good effect on clinical management. The study showed the necessity to develop the on call service in MRI.
Chatt Maa Shi Hosp Med Coll J; Vol.21 (1); January 2022; Page 14-18
Medical Education Amidst the COVID-19 Pandemic: A Takeaway from Perspectives of Medical Students of Bangladesh
Authors: Parveen Mosammat Kohinoor , Hannan Md Jafrul , Ferdoush Jannatul 
Published: May 2022

Background: The objective of this study was to understand the factors which have positively and negatively affected delivery of medical education in Bangladesh during the COVID-19 epidemic and to apply this knowledge to improve preparedness in the event of future COVID spikes or other pandemics.
Materials and methods: A 20-question survey was constructed and responses from over 300 medical students across Bangladesh were received and statistically examined by chi-squared, logistic regression and latent class analysis.
Results: Quality of internet connection has the biggest impact on delivery of highquality online courses. General experience with online course delivery through number of courses attended and year in the program were also impactful. Latent class analysis indicated that two classes of students existed with regards to their answers (Yes/No/Undecided) as to whether they would attend class or sit professional exams if schools reopened. The characteristics of each class were diverse and enabled a glimpse into the psyche of the students.
Conclusions: The results demonstrated a need for government to ensure every one has access to a good quality internet. Not only will it improve the perception of online medical courses, it will prevent students from unnecessary travelling increasing the risk of transmission. With experience in developing online curricula, the misconception that it is inferior to classroom equivalent may be reduced. More confidence in the quality of online classes may encourage more students that are apprehensive about the professional exams to regain their self-confidence and sit them and increase the pool of independently practicing physicians in Bangladesh.
Chatt Maa Shi Hosp Med Coll J; Vol.21 (1); January 2022; Page 41-46