bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonlinear characteristic analysis of gas-interconnected quasi-zero stiffness pneumatic suspension system:A theoretical and experimental study
Authors: Jiang Xinwei , Xu Xing , Shi Tianling , Atindana Vincent Akolbire 
Published: November 2022

Abstract
Since traditional air suspension system is limited to respond the greatly changed load of commercial vehicles, a new Gas-Interconnected Quasi-Zero Stiffness Pneumatic Suspension (GIQZSPS) is presented in this paper. Firstly, a nonlinear mechanical model including the dimensionless stiffness characteristic and interconnected pipeline model is derived for GIQZSPS system. The restoring force of suspension system is simplified by Taylor series expansion, which is brought into the motion differential equation and the steady-state response solution is obtained by using the harmonic balance method. Next, the influence of stiffness and damping ratio on the jump frequency is discussed, and the vibration isolation performance of GIQZSPS system is analyzed by adopting the force transmissibility rate as the evaluation index. Finally, a testing bench simulating 1/4 GIQZSPS system is designed, and the testing analysis of the model validation and isolating performance is carried out. The results show that the proposed GIQZSPS system in gas connected and disconnected states have the same natural frequency, and GIQZSPS system in the disconnected state has higher stiffness but is sensitive to load changes. Meanwhile, the proposed GIQZSPS system in the connected state has a higher resonance peak value and exhibits better vibration isolation at higher loads. Accordingly, the proposed GIQZSPS system can adjust the connectivity status according to different load conditions.
The Charlson Age Comorbidity Index Associated with Geriatric Patient’s Mortality after Emergency Surgery: A prospective National Multicenter Study
Authors: Isngadi Isngadi , Asmoro Aswoco A , Hariyanto Achmad , Siswagama Taufiq A , Rehatta Nancy M , Chandra Susilo , Sari Djayanti , Lestari Mayang I , Senapathi Tjokorda GA , Nurdin Haizah , Wirabuana Belindo , Pramodana Bintang , Pradhana Adinda P , Anggraeni Novita , Sikumbang Kenanga M , Halimi Radian A , Jasa Zafrullah K , Nasution Akhyar Hamonangan , Mochamat Mochamat , Purwoko Purwoko 
Published: November 2022

Abstract
Background
Aging is an irreversible, progressive and cumulative process that involves biological, anatomical, physiological, and functional changes that occur over a period of time. Emergency surgery in geriatrics is challenging due to the limited time for surgery planning. Charlson Age Comorbidity Index (CACI) can be used as a predictor of mortality in geriatric patients undergoing surgery. The study’s aim is to determine the association between CACI and mortality in geriatric patients undergoing emergency surgery.
Methods
This study was a prospective analytic observational multicenter study. This study was conducted from February 2021 to April 2021. This study used the whole sampling method and was followed up 30 days after surgery. The data were analyzed using regression and the ROC Curve test with a confidence interval of 95%.
Results
We obtained 116 geriatric patients undergoing emergency surgery with a 30-day mortality rate of 11.2%. CACI significantly correlated with 30 day-mortality in geriatric underwent emergency surgery (p = 0.000) with B = 4.831. The AUC of the CACI score was 0.966, with a cut-off value of 5.5. For geriatric patients with CACI scores > 5.5, the risk of mortality within 30 days of treatment is 125.33 times greater (95% CI: 14.58–1077.67) than for patients with CACI scores < 5.5.
Conclusion
CACI is associated with 30-day mortality in geriatric patients undergoing emergency surgery. CACI score also could be used to predict 30-day mortality in geriatric underwent emergency surgery.
Attitude and Readiness to Online Learning and Challenges among First-Year Medical Students
Authors: Limenie Abebaye Aragaw 
Published: November 2022

AbstractBackground Most of the systems, including education, in the world are becoming web and technology-based. Assessing students’ attitudes, readiness, and challenges is important for effective implementation. This study is, therefore, aimed to assess students’ attitudes, readiness, and challenges affecting online learning among medical students at Addis Ababa University, School of Medicine. Methods a total of 150 undergraduate medical students were involved in this study. A quantitative cross-sectional research design was used. Data were collected through a structured google form questionnaire. A 5-point Likert scale instrument was used to measure students ’ level of agreement on the items of attitude, readiness, and challenges affecting their online learning activities. The data obtained were analyzed using SPSS (version 26). Independent t-test and one-way ANOVA followed by Post Hoc Turkey multiple comparison tests were used. The data were expressed as means ± standard deviation (SD). Differences with p < 0.05 were considered statistically significant. Results Students’ attitudes toward online learning were high (mean: 3.49) and significantly affected by extra computer training at the high school level (t (148) = 2.57, p = .010), basic computer skills (F (3,146) = 5.65, p = .001), online learning accessing skills (F (3,146) = 2.71, p = .048) and online learning destructors eliminating skills (F (3,146) = 15.99, p = .000). The readiness was moderate (mean = 3.23) and was significantly higher in males than females (t (148) = 2.17, p = .032). The readiness of the students for online learning was significantly affected by personal (mean = 2.60; SD = .56 vs mean = 2.40; SD = .68; p = .037) and technological (mean = 2.61; SD = .05 vs mean = 2.40; SD = .68; p = .027) related challenges than institutional challenges. Unavailable of quality technology was the first technology-related challenge affecting medical students’ online learning (mean = 3.16), while the students’ perception was the first challenge in the personal-related factors (mean = 3.31). Conclusion Students’ attitudes towards online learning were high and affected by extra computer training at the high school level. Readiness was moderate and affected by gender. Students should increase their computer skills and it is required to motivate females to practice online learning. Educational management is required to select appropriate online-teaching tools before starting online teaching.
A multi-blockchain system application based on improved PBFT consensus mechanism for online rumor co-governance
Authors: Chen Yuetong , Liu Fengming 
Published: November 2022

Abstract
At present, there are difficulties in the governance of Internet rumors, such as slow control and information barriers. In the face of the confused and complex social public opinion environment, it is urgent to innovate technical means to break through the bottleneck of rumor prevention and control. Firstly, based on the architecture characteristics and core technologies of blockchain, this paper designs a multi-blockchain system architecture for the collaborative co-governance scenario of online rumors, and puts forward the design ideas of smart contracts and consensus mechanisms for the functions of different chains, so as to enable different chains and different nodes within each chain to achieve collaborative interaction of rumor dispelling and rumor suppression strategies. Secondly, according to the requirements of the rumor co-governance scenario, we improve the original PBFT consensus algorithm on the basis of analyzing the defects, and propose the RK-PBFT consensus mechanism based on rumor refutation reliability and K-Medoids clustering algorithm. Through the simulation experiment, the algorithm is compared before and after the improvement. The results show that the delay of the proposed improved consensus algorithm is significantly reduced and the throughput is greatly improved, in addition, in the case of the same number of nodes, the more the number of packets, the lower the delay and the higher the throughput. This means that the proposed consensus algorithm not only improves the delay and throughput performance of the original algorithm, but also ensures the reliability and operation efficiency of the rumor co-governance system.
Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsy
Authors: Sandouka Sereen , Saadi Aseel , Singh Prince Kumar , Olowe Rhoda , Shekh-Ahmad Tawfeeq 
Published: November 2022

Abstract
Background
Drug resistance is a particular problem in patients with temporal lobe epilepsy, where seizures originate mainly from the hippocampus. Many of these epilepsies are acquired conditions following an insult to the brain such as a prolonged seizure and are characterized by pathophysiological mechanisms that synergistically mediate the secondary brain damage, prominently including massive oxidative stress that evolves over time, contributing to the development of epilepsy. The transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) has emerged in recent years as an attractive therapeutic approach targeting to upregulate the antioxidative defenses in the cell, to ameliorate the oxidative stress-induced damage. Thus, it is important to understand the characteristics of Nrf2 activation during epileptogenesis and epilepsy. Here, we studied the temporal, regional, and cell-type specific expression of Nrf2 in the brain, in a rat model of temporal lobe epilepsy.
Results
Early after status-epilepticus, Nrf2 is mainly activated in the hippocampus and maintained during the whole period of epileptogenesis. Only low expression of Nrf2 was observed in the cortex. Nevertheless, the expression of several Nrf2 antioxidant target genes was increased within 24-hrs after status-epilepticus in both the cortex and the hippocampus. We demonstrated that after status-epilepticus in rats, Nrf2 is predominantly expressed in neurons in the CA1 and CA3 regions of the hippocampus, and only astrocytes in the CA1 increase their Nrf2 expression
Conclusions
In conclusion, our data identify previously unrecognized spatial and cell-type dependent activation of Nrf2 during epilepsy development, highlighting the need for a time-controlled, and cell-type specific activation of the Nrf2 pathway for mediating anti-oxidant response after brain insult, to modify the development of epilepsy.
Regulation of dental consultations in primary health care and performance of services in Dental Speciality Centers
Authors: Silva Barbara Campos da , Viana Jhenyffer Andrade , Buzinaro Giovana Soares , Cunha Inara Pereira da , de Lacerda Valéria Rodrigues , Bomfim Rafael Aiello 
Published: November 2022

Abstract
Objective: This study analyzed the regulation of dental specialty centers (CEOs) coordinated exclusively by Primary Health Care (PHC) in four primary outcomes: access and dental consultation, reception services, bonding and responsibility, and social participation.
Methods: A cross-sectional study was carried out using secondary data from the National Program for the Improvement of Access and Quality of Dental Specialty Centers (PMAQ-CEO): second cycle, using multilevel logistic regression to calculate the odds ratio (OR) and individual covariates.
Results: The analytical sample consisted of 9,599 CEO users who had completed all the variables analyzed. Of these, 63.5% were referred to the CEO by PHC. Dental care regulated by PHC was related to better access (OR 1.36, CI 95% 1.10-1.68), better reception (OR 1.33, CI 95% 1.03-1.71), better bonding and responsibility (OR 1.36, CI 95% 0.91-2.04), and social participation (OR 1.13, CI 95% 0.93-1.35) compared to those not regulated by primary health care as the exclusive pathway.
Conclusion: The regulation of access to the CEO coordinated by PHC presented the best performance. It is suggested that this form of PHC regulation, as a route for dental specialty centers, can be established in the national oral health care policy for better service performance.
Mystery of Siljan Crater
Authors: Kutcherov Vladimir , Buzilov Alexander , Postnikov Alexander 
Published: November 2022

Abstract
A substantial number of ring structures have been identified on the Earth's surface. The overwhelming majority of these structures are considered meteorite craters. Signs of impact metamorphism argue for the impact origin of such structures although this cannot be considered an indisputable confirmation of their origin. Impact appearance can be explained by both exogenous and endogenous causes. Among the latter are high-temperature mantle gas explosions. We have found at least four stages of tectonic dislocations in the basement rocks of the Siljan ring structure, which favor the explosive eruptions origin hypothesis. It can thus be assumed that many ring structures referred to as impact structures are of terrestrial origin.
Survival Benefit of Lymphadenectomy for Endometrioid Carcinoma of Ovary: A SEER-based Study
Authors: Zhu Jing , Kang Lin , Li Haili 
Published: November 2022

Abstract
Background. The potential therapeutic benefits of lymphadenectomy for patients with ovarian endometrioid carcinoma (EOC) remain vague. Therefore, a retrospective population-based analysis was performed to determine the relationship between lymphadenectomy and the survival rate of female patients with EOC.
Materials and Methods. The surveillance, epidemiology and final results (SEER) program database was retrospectively analyzed and data were collected on 6106 female patients with EOC from 2004 to 2015. Main patient and tumor characteristics include marital status, age, ethnicity, time of diagnosis, stage, stage, grade, tumor size, radiotherapy, treatment, chemotherapy, and lymphadenectomy status. Using the IT-AIC method to estimate the effects of lymphadenectomy in a multivariate environment, Kaplan-Meier and Cox proportional risk regression analysis was performed to determine the relationship between lymphadenectomy and EOC overall survival (OS) and cancer-specific survival (CSS).
Results. A total of 3587 and 1332 women with stage I and III-IV EOC who met the inclusion criteria were identified. Lymphadenectomy 2738 (76.3%) and 786 (59.0%) (P < 0.001). With multivariate analysis, lymphadenectomy as a classification and continuous variable is an independent prognostic factor, and patients with lymphadenectomy have a better prognosis. And the results showed that age, marital status, TNM staging, grading, surgery, chemotherapy and lymphadenectomy had a significant correlation with the CSS of EOC, and the age < 50 years, chemotherapy, early staging and early grading, and women with EOC who did not undergo debulking surgery and married had a better prognosis.
Conclusions. Lymphadenectomy can improve long-term OS and cancer-specific survival (CSS) of EOC.
A framework for developing context-aware mobile applications based on modularity, scalability, and compatibility
Authors: Magalhães Clayton , de Marchi Ana Carolina B. , de Bortoli Lis Angela 
Published: November 2022

Abstract

Research highlights the growing expansion of mobile devices equipped with sensors that enable the adaptation of context-aware applications. Thus, approaches that guide the development of these applications must be investigated. This study presents a framework for the development of a context-aware mobile application, through integrated representation models, architecture, and implementation guidelines, considering principles of modularity, scalability, and compatibility. To verify the assertiveness of the conceptual model and the proposed architecture, an evaluation was conducted with three systems analysts. The experts were able to practice the proposed concepts by answering a feedback questionnaire. The study also included the development of a mobile application with context-aware features, considering the guidelines defined in the framework. The application focused on dietary care and was tested by six nutrition professionals. After using the application for seven days, the professionals answered a context-aware perception questionnaire about the functionalities. Data were analyzed and the results showed that the feedback was satisfactory. Furthermore, the application created from the framework verified the feasibility of the proposed structure through its practical use with software experts and a case study.
Systematic and benchmarking studies of pipelines for mammal WGBS data in the novel NGS platform
Authors: Lin Qun-ting , Yang Wei , Zhang Xin , Li Qi-gang , Liu Yong-feng , Yan Qin , Sun Lei 
Published: November 2022

Abstract
Background:
Whole genome bisulfite sequencing(WGBS), possesses theaptitude to dissect methylation status at the nucleotide-level resolution of 5-methylcytosine(5mC) on a genome-wide scale. It is a powerful technique for epigenome in various cell types, and tissues. As a recently established next-generation sequencing(NGS) platform, GenoLab M is a promising alternative platform. However, its comprehensive evaluation for WGBS has not been reported. We sequenced two bisulfite-converted mammal DNA in this researchusing our GenoLab M and NovaSeq 6000, respectively. Then, we systematically compared those data via four widely used WGBS tools: BSMAP, Bismark, BatMeth2, and BS-Seeker2. We interrogated their computational time, genomedepth and coverage, and evaluated their percentage of methylated Cs.
Result:
Here, benchmarking a combination of pre- and post-processing methods, we found that trimming improved the performance of mapping efficiency in eight datasets. The data from two platformsuncovered ~80% of CpG sites genome-wide in the human cell line. Those data sequenced by GenoLab M achieved a far lower proportion of duplicates(~5.5%). Among pipelines, BSMAP provided an intriguing representation of 5mC distribution at CpG sites with 5mC levels >~78% in datasets from human cell lines, especially in the GenoLab M. BSMAP performed more advantages in running time, uniquely mapped reads percentages, genomic coverage, and quantitative accuracy. Finally, comparedwith the previous methylation pattern of human cell line and mouse tissue, we confirmed that the data from GenoLab M performed similar consistency and accuracy in methylation levels of CpG sites withthat from NovaSeq 6000.
Conclusion:
Together we confirmed that GenoLab M was a qualified NGS platform for WGBS with high performance. Our results showed that BSMAP was the suitable pipeline that allowed for WGBS studies on the GenoLab M platform.
Probing BERT on Syntactic Representation Paradigms: Dependency vs Constituency Trees
Authors: Alzetta Chiara , Miaschi Alessio , Dell'Orletta Felice , Venturi Giulia , Montemagni Simonetta 
Published: November 2022

Abstract
On the quest for interpreting deep Neural Language Models (NLMs), linguistically annotated probing sets are essential tools for investigating models' linguistic abilities. Such a line of research is currently dominated by dependency-based syntactic annotation formalisms, and particularly by Universal Dependencies treebanks. In this work, we test whether different Syntactic Representation Paradigms (SRP) have an impact on the performance of NLMs. To this aim, we set up a multilingual study where we compare the scores obtained by BERT on a set of probing tasks performed on 10 treebanks annotated according to two paradigms, i.e. the dependency and the constituency one, which diverges on fundamental annotation principles. Results suggest that BERT performance is minimally but consistently affected by SRPs and that such impact mostly concerns specific linguistic phenomena.
A Novel Rat-Tail Model for Studying Human Finger Vibration Health Effects
Authors: Dong Ren G. , Warren Christopher , Xu Xueyan S. , Wu John Z. , Welcome Daniel E. , Waugh Stacey , Krajnak Kristine 
Published: November 2022

Abstract
It has been generally hypothesized that the biodynamic responses to vibration such as vibration stress, strain, and power absorption density of the human finger tissues are among the major stimuli that cause vibration health effects, because mechanics regulates biological processes. Furthermore, the finger contact pressure can affect these effects. It is difficult to test these hypotheses using human subjects or existing animal models. Therefore, the objective of this study was to develop a new rat-tail exposure system and its related analytical method to investigate the combined effects of vibration and contact pressure and to identify their relationships with the biodynamic responses. Physically, the new exposure system was developed based on the existing NIOSH rat-tail model by adding a loading device to it. An analytical model of the rat-tail exposure system was also proposed and used to formulate the methods for quantifying the tail biodynamic responses required to test the hypotheses. A series of experiments with a tail dissected from a rat cadaver were conducted to test and evaluate the new tail model. The experimental and modeling results demonstrate that the new model behaves as designed. Unlike the previous model, the vibration strain and stress of the rat tail do not depend primarily on the vibration response of the tail itself but on that of the loading plate. This makes it possible to quantify and control the biodynamic responses conveniently and reliably by measuring the plate response. Examples of the quantified tail biodynamic responses are demonstrated and discussed.
Systematic Pan-Cancer Analysis Identifies SLC31A1 as a Biomarker in Multiple Tumor Types
Authors: Kong Fan-Sheng , Ren Chun-Yan , Jia Ruofan , Zhou Yuan , Chen Jian-Huan , Ma Yaping 
Published: November 2022

Abstract
Background
Solute Carrier Family 31 Member 1 (SLC31A1) has recently been identified as a cuproptosis-regulatory gene. Recent studies have indicated that SLC31A1 may play a role in colorectal and lung cancer tumorigenesis. However, the role of SLC31A1 and its cuproptosis-regulatory functions in multiple tumor types remains to be further elucidated.
Methods
In this study, we used some website tools such as HPA, GEPIA2 and cBioPortal to estimate the expression, genetic alteration and prognostic in multiple cancer types. TIMER2 was used to evaluate the cancer-associated fibroblast infiltration. DAVID and BioGRID were used to conduct functional analysis and constructe the PPI network, respectively.
Results
In general, the TCGA datasets showed increased SLC31A1 expression in tumor tissues compared with non-tumor tissues in most tumor types. In patients with tumor types including Adrenocortical Carcinoma (ACC), Low-Grade Glioma (LGG), or Mesothelioma (MESO), higher SLC31A1 expression was correlated with shorter overall survival (OS) and disease-free survival (DFS). Moreover, the expression of SLC31A1 was also implicated to be positively correlated with the infiltration of fibroblasts into tumor tissues. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that SLC31A1 co-expressed genes were involved in protein binding, integral components of the membrane, metabolic pathways, and protein processing in the endoplasmic reticulum. Protein-protein interaction network analysis showed that SLC31A1 interacted with Copper Chaperone for Superoxide Dismutase (CCS), and Erb-B2 Receptor Tyrosine Kinase 3 (ERBB3), which had been known to be associated with copper transportation and tumorigenesis.
Conclusions
These findings demonstrated that SLC31A1 is associated with multiple tumor types and prognosis. SLC31A1 may be a potential key biomarker and therapeutic target in cancers. As a result, it will be a novel new therapy for cancer patients to improve the prognosis of cancer patients.