bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between pregnancies complicated with fetal growth restriction and umbilical cord blood endocan concentrations
Authors: Özgökçe Çağdaş , Uçkan Kazım , Meral Ayfer 
Published: March 2022

Abstract

Objectives
The main etiological factor in intrauterine growth restriction (IUGR) is the impairment of the fetoplacental unit. Due to the placental endothelial disintegrity and vascular permeability disruptions, endocan has been an interesting molecule to search for associations with IUGR. The aim of this study was to investigate the umbilical cord blood endocan concentrations in IUGR pregnancies.

Methods
This cross-sectional case-control study was conducted on 50 IUGR-complicated (patients) and 50 control pregnancies. The demographics and clinical findings were recruited from records. The umbilical cord blood was studied for endocan concentrations.

Results
The patient group compared to controls had significantly more previous IUGR history, lower maternal weight gain, an earlier gestational week at delivery, and more cesarean sections (p<0.001). The umbilical cord endocan concentrations were significantly higher in patients than in controls (p<0.001). Oligohydramnios (n=38) was significantly higher in the patients and had a significant relationship with high endocan concentrations (p<0.001). Moderate and mild positive correlations were found among endocan concentration and biparietal diameter/head circumference and femur length values, respectively, while a moderate negative correlation was observed in abdominal circumference values (p<0.001).

Conclusions
A significant increase in the umbilical cord blood endocan concentrations was found in IUGR pregnancies.
Deutung der Technologie als Lehre vom Wandel der Technik
Authors: Spur Günter 
Published: March 2022

Abstract
Technik ist in die kulturelle Entwicklung des Menschen eingebunden. Sie dient der Anpassung und Wandlung unserer Lebensgestaltung und kann somit auch als Reaktion des Menschen auf seine Umwelt gedeutet werden. Die technologische Industrialisierung unserer Wirtschaft hat das Leben der Menschen so grundlegend beeinflußt, daß sie retrospektiv als industrielle Revolution beschrieben wurde. Diese Entwicklung ist jedoch über mehrere Generationen verlaufend eher als Evolution zu deuten.
Stoßkraftmessung beim Strahlen mit CO2-Pellets
Authors: Uhlmann Eckart , Axmann Bernhard , Elbing Felix 
Published: March 2022

Abstract
Im Rahmen einer experimentellen Analyse wurden die Strahlstoßkräfte beim Trockeneisstrahlen bestimmt. Ergebnis sind Aussagen über die Deformation und Oberflächenschädigung des Strahlguts sowie die kinetische Energie der Trockeneispellets. In diesem Beitrag wird der Einsatz des Verfahrens zum Reinigen, Entschichten und Entlacken aufgezeigt.
Verifikation zertifizierungspflichtiger Steuerungssoftware*
Authors: Meier Horst , Mertke Thomas 
Published: March 2022

Abstract
Die Anwendung der SPS-basierten Automatisierungstechnik in sicherheitskritischen Bereichen setzt das Vorhandensein vertrauenswürdiger Hard- und Software voraus. Während auf dem Gebiet der Hardware bereits einige Lösungen am Markt etabliert sind, stellt die Erzeugung funktional korrekter und zertifizierter Software immer noch ein beträchtliches Problem dar. Die heutigen Methoden und Verfahren, mit denen die Zertifizierungsstellen die Prüfung und Verifikation der Software vorzunehmen haben, sind meist sehr mühevoll sowie zeitaufwendig und garantieren trotzdem keine vollständige Sicherheit.
Neue Ansätze in der numerischen Steuerungstechnik
Authors: Pritschow Günter , Hohenadel Jürgen , Reichle Rolf 
Published: March 2022

Abstract
Hersteller von Maschinen und Anlagen sowie deren Betreiber unterliegen heute einem sehr hohen Wettbewerbsdruck. Sie sind gefordert, sämtliche Rationalisierungspotentiale auszuschöpfen. Hierbei fällt den numerischen Steuerungen eine besondere Aufgabe zu. Flexibilität, Skalierbarkeit und Offenheit bei geringen Entwicklungs- und Betriebskosten stehen im Vordergrund der aktuellen Entwicklungsbemühungen. Im folgenden werden neue Ansätze aus dem Bereich der numerischen Steuerungstechnik aufgezeigt, mit denen auf die bestehenden Herausforderungen reagiert werden kann.
Parallelkinematiken in der Robotertechnik
Authors: Hesselbach Jürgen , Kusiek Arne , Frindt Matthias 
Published: March 2022

Abstract
Lange vor der momentan herrschenden Diskussion im Werkzeugmaschinenbau über den Einsatz neuer Maschinenkonzepte auf der Basis paralleler Kinematiken (z. B. den Hexapoden) wurde deren Umsetzung in anderen Bereichen bereits konsequent verwirklicht. Obwohl anfangs wenig beachtet, entwickeln sich diese Strukturen insbesondere in der Robotertechnik zu einer leistungsfähigen Alternative bzw. Ergänzung zu den konventionellen seriellen Strukturen.
Unternehmensplanung von der Fertigungszelle bis zum Unternehmensnetzwerk
Authors: Mertins Kai 
Published: March 2022

Abstract
Werkzeuge zur Planung und Steuerung der Fabrik werden seit 1982 am Bereich Planungstechnik des Fraunhofer Institutes IPK, vorher am Institut für Werkzeugmaschinen und Fertigungstechnik (IWF) der TU-Berlin erarbeitet. Der Aufsatz zeichnet wesentliche Phasen und Lösungsbereiche des Bereichs Planungstechnik nach.
Strategisches Produktionsmanagement
Authors: Gausemeier Jürgen , Fink Alexander , Riepe Bernd 
Published: March 2022

Abstract
Die Identifikation der Produkte und die Eroberung der Märkte von morgen sind eine herausfordernde Aufgabe. Um dieser Aufgabe gerecht zu werden, wird ein ganzheitliches Modell der zukunftsorientierten Führung von produzierenden Industrieunternehmen vorgeschlagen. Es umfaßt die Bereiche von der Szenarioerstellung über die Strategieentwicklung und die Prozeßoptimierung bis zur Einführung von Systemen der Informationstechnik (IT). In diesem Beitrag wird schwerpunktmäßig auf Optimierung sowie Simulation von Geschäftsprozessen und Informationsflüssen in virtuellen Umgebungen eingegangen.
Fertigungstechnik
Authors: Uhlmann Eckart , Doll Ullrich , Brücher Marcus 
Published: March 2022

Abstract
Qualität und Kosten industrieller Produkte werden maßgeblich von der angewandten Fertigungstechnologie bestimmt. Eine technologische Spitzenposition erfordert deshalb Kenntnisse über eine zeitoptimierte, reproduzierbare Fertigung unter Gewährleistung der geforderten Bauteilgenauigkeit sowie Oberflächenbeschaffenheit bei möglichst weitgehender Einsparung von Ressourcen und Vermeidung von Umweltbeeinträchtigungen.
Montagetechnik und Fabrikbetrieb
Authors: Seliger Günther 
Published: March 2022

Abstract
Die Auslegung ausgewählter Komponenten von Fertigungs- und Montagesystemen, ihre Planung und Steuerung mit geeigneten informationstechnischen Werkzeugen, die experimentelle Analyse und Modellierung von Füge- und Handhabungsprozessen sowie die simultane Gestaltung von Produkten und Prozessen haben das Forschungsprofil von Montagetechnik und Fabrikbetrieb im PTZ Berlin in den vergangenen zwei Jahrzehnten geprägt. Im folgenden werden die wesentlichen Initiativen vorgestellt.
Optimierung von automatisierten Bestücksystemen
Authors: Feldmann Klaus , Schlögl Wolfgang 
Published: March 2022

Abstract
Die Baugruppenherstellung in der Elektronikproduktion steht vor neuen Herausforderungen sowie verstärktem internationalen Konkurrenzdruck. Ein wesentlicher Aspekt, das dabei anfallende Investitionsrisiko zu minimieren, ist die Verwendung durchgängiger Planungsmodelle. Der folgende Beitrag diskutiert die mögliche Realisierung eines solchen Ansatzes durch den Einsatz maschinennaher Referenzmodelle.
Robotertechnik am Produktionstechnischen Zentrum Berlin
Authors: Bernhardt Rolf 
Published: March 2022

Abstract
Die Arbeiten im Bereich der Robotertechnik am IWF und später am IPK in Berlin begannen im Jahre 1973 mit dem Erwerb eines zu jener Zeit noch seltenen Roboters. In diesem Beitrag werden die danach folgenden Projekte und Entwicklungen am IPK insbesondere mit dem Blick auf die Steuerung von Robotern und ihrer Simulation vorgestellt.
Morfología, calidad de semillas y plántulas de Yucca endlichiana e implicaciones en su conservación
Authors: Meza-Cota Ana Bertha , Vargas-Hernández J. Jesús , Vázquez-Badillo Mario Ernesto , Villarreal-Quintanilla José Ángel , López-Aguillón Ricardo , Florez-López Celestino 
Published: March 2022

La Yucca endlichiana Trel. es una especie microendémica en el estado de Coahuila y en estatus de protección especial. El objetivo fue conocer la variabilidad morfológica, calidad de semilla y de plántula de Y. endlichiana para proponer acciones de conservación. Se colectaron cápsulas en más de 30 plantas seleccionadas en las localidades El Dorado, San Antonio del Jaral y Las Coloradas. A las que se les evaluaron ocho variables morfológicas, siete de calidad de semilla, y una en plántula. El análisis de varianza diferenció morfológicamente a la semilla de El Dorado en el peso de 100 semillas, grosor de semilla y testa. En las pruebas de sanidad en PDA (agar de papa y dextrosa) y MSA (agar manitol salado), las localidades presentaron incidencia de los hongos Aspergillus niger (61.11% PDA y 66.66% MSA) y A. flavus (50.00% PDA y 50.00% MSA). No hay diferencias significativas entre las localidades para viabilidad de semillas, germinación de plántulas normales y anormales, vigor de germinación y calidad de plántula. Los valores óptimos en calidad de semilla y plántulas de Y. endlichiana facilitarán la conservación in situ y ex situ en el establecimiento de unidades productoras de germoplasma forestal y el manejo de semillas en bancos de germoplasma, valorando la selección de individuos en la conservación a corto y largo plazo.
Percepción y adaptación de productores de café al cambio climático en Puebla y Oaxaca, México
Authors: Jaramillo-Villanueva José Luis , Guerrero-Carrera Jesus , Vargas-López Samuel , Bustamante-González Ángel 
Published: March 2022

El objetivo de la presente investigación fue analizar los factores explicativos de la percepción y adaptación de los productores de café al cambio climático en la región Mazateca de Oaxaca y Cuetzalan de Puebla. La información se obtuvo de una encuesta a productores de café, en la que se incluyeron preguntas sobre características sociodemográficas del productor, uso de tecnología agrícola, costos e ingresos, percepción, adaptación y afectaciones al cultivo de café por cambio climático. Se aplicó muestreo aleatorio simple, con 95% de confiabilidad y 10% de precisión. Los productores identificaron que el cambio climático está afectando el rendimiento y la calidad del producto. La percepción del riesgo esta correlacionada de forma significativa (p < 0.05) con medida de adaptación al cambio climático. Los factores explicativos de la percepción que fueron significativos (p < 0.05) son recibir asistencia técnica, escolaridad alta, ingreso del hogar alto, tamaño de más de 2.0 ha de la plantación y haber tenido afectaciones por cambios en el clima en los últimos cinco años. Recibir asistencia técnica contra no recibirla y tener escolaridad alta contra escolaridad baja aumentaron el logaritmo de la razón de probabilidades por 0.82 y 0.61, respectivamente. Tener ingreso alto incrementó la probabilidad de realizar adaptaciones (66%). Los cafeticultores tienen una fuerte percepción sobre las alteraciones climáticas y su impacto en los agroecosistemas de café. Se encontró una correlación significativa entre percepción y adaptaciones al cambio climático.
Aspects of readiness of higher education teachers for continuing professional development
Authors: Potapchuk Tetiana , Prima Dmutro , Yana Levchuk , Serhii Zahorodnii , Roslavets Ruslana , Prima Raisa 
Published: March 2022

The article highlights the necessity to increase attention to the formation of the readiness of teachers of higher education institutions for continuing professional self-improvement. The readiness of teachers for professional self-improvement is considered a multifaceted personal-professional formation, structurally represented by the unity of functionally interconnected components: motivational-value, organizational-activity; emotional and volitional; information-cognitive, reflexive-evaluative. The criteria for diagnosing this phenomenon are differentiated: awareness of the necessity for purposeful continuing professional self-improvement; theoretical training, the level of professionally oriented knowledge, practical and operational training, the formation of practical skills and abilities of professional self-improvement. A set of individual psychological qualities important for continuing professional self-improvement and future professional activity in general; focus on self-analysis, self-assessment of professional improvement are analyzed. The levels of teachers’ readiness for continuing professional self-improvement are determined and characterized: critical, passive, basic, optimal, creative. We also defined several aspects of analysis and self-analysis of professional activity, training through the organization of personality-oriented interactive activities, updating teachers’ professional experience, ensuring a selective attitude to problems, educational material, focusing on the formation and implementation of the program of personal and professional self-development.
Patients Who Reviewed a Decision Aid Prior to Major Orthopaedic Surgery Reported Higher Trust in Their Surgeon
Authors: Brodney Suzanne , Sepucha Karen , Chang Yuchiao , Moulton Ben , Barry Michael J. 
Published: March 2022

Background:
Decision aids (DAs) are utilized to ensure that patients are informed and involved in the decision-making process. Although DAs improve decision quality, other aspects of the decision-making process, such as trust and regret, are seldom measured. The objective of the present study was to determine whether patients given a DA prior to orthopaedic surgery had greater trust and lower regret at 6 months postoperatively.

Methods:
Consecutive patients were identified who underwent a hip or knee replacement or spine surgery from October 2018 to January 2020 and were subsequently surveyed at 6 months postoperatively. Outcomes included the Trust in the Surgical Decision and Decision Regret Scales. The primary analysis compared scores of patients who reviewed at least some of the DA to those who had not received or reviewed it. A sensitivity analysis compared patients with a DA order who reported reviewing it to those who did not. Multivariable models analyzed whether DA exposure predicted trust or regret. An exploratory mediation analysis examined the direct and indirect effects of DA exposure, including through the Shared Decision Making Process score.

Results:
The response rate was 56% (700 of 1,253). In the primary analysis, the proportion of patients who reported complete trust was 50.9% among those with no DA review and 63.8% among those with DA review (adjusted odds ratio, 1.62; 95% confidence interval, 1.11 to 2.36). A nonsignificant effect was observed comparing a DA order (59.9%) versus no DA order (51.4%; adjusted odds ratio, 1.30; 95% confidence interval, 0.80 to 2.11). Regret was unrelated to DA exposure. In the mediation analysis, 19.3% (95% confidence interval, 3.1% to 35.4%) of the effect of DA review on trust could be attributed to increased shared decision making.

Conclusions:
Patients who reviewed a DA prior to orthopaedic surgery reported higher trust in their surgeons.

Clinical Relevance:
Providing patients with a DA prior to orthopaedic surgery can improve trust in the surgeon. Improving trust between patients and surgeons may improve communication and help patients make better health decisions.
The Impact of Fracture Geometries on Heterogeneity and Accuracy of Upscaled Equivalent Fracture Models
Authors: Chen Tao 
Published: March 2022

Abstract
Fractures are widely distributed in the upper crust, which is important to transport processes in groundwater, geothermal, and hydrocarbon reservoirs. Little attention has been paid to the heterogeneity and accuracy of upscaled equivalent fracture models (EFMs) regarding the complex fracture geometries during numerical reservoir simulation. This paper investigates how fracture geometric properties affect the accuracy of highly heterogeneous EFMs. An ensemble of synthetic fractured porous rocks is generated stochastically with varied fracture length, fracture density, and aperture-length correlation. Each realization is upscaled to EFM with the recently developed multiple boundary method. Flow problems are solved for EFMs and discrete fracture models (DFMs) simultaneously, and their flow rates are compared. The results demonstrate that the heterogeneity of EFMs decreases with the number and length of fractures and increases with the aperture-length correlation component. The flow rates calculated by EFMs fit well with those by DFMs with a slope around 1.08 and R2 coefficient above 0.98. The accuracy of the upscaled EFM decreases when the aperture-length correlation changes from sublinear to linear. The uncertainty of upscaling accuracy decreases with dimensionless fracture density. The findings of this study can help for a better understanding of the effect of the discrete fracture geometries on the performance of upscaled EFMs and choosing the appropriate models for different kinds of fractured reservoirs.
Permian Remelting and Maturity of Continental Crust Revealed by the Daqing Peraluminous Granitic Batholith, Inner Mongolia
Authors: Li Jialiang , Liu Jingao , Wu Chen , Zhu Di-Cheng 
Published: March 2022

AbstractThe Phanerozoic granites in northeast China bear key information for studying the tectonic evolution and crustal growth or reworking in the Central Asian Orogenic Belt (CAOB). The Daqing granitic batholith widely outcrops as a high-level intrusion in the Xing’an-Mongolia Orogenic Belt, southeastern CAOB. Three types of enclaves in granites have been identified: (1) mafic magmatic enclaves (MMEs), (2) volcanic xenoliths, and (3) biotite-rich enclaves. The batholith is mainly composed of peraluminous biotite granite and granodiorite with SiO2=63.95−69.48 wt.%, A/CNK=1.15−1.27, and 2.54 to 4.30 wt.% of normative corundum. They exhibit remarkable enrichment in large ion lithophile elements (LILEs; K, Rb, Th, and Pb) and depletion in high field strength elements (HFSEs; Nb, Ta, and Ti), P, Eu, and Sr, as well as relatively enriched Sr-Nd isotopes (87Sr/86Sri=0.70530−0.70576, εNdt=–0.1−+0.2). Zircon U-Pb dating suggests that this batholith was emplaced in the Early Permian (ca. 283-282 Ma), consistent with a period of intensive magmatic activities in northern Inner Mongolia. The Nb/Ta ratios of MMEs (17.6-20.1) are higher than those of the host granites (11.4-12.5), together with the reaction rims where biotite crystals cluster around the amphibole cores, suggesting magma mixing between mantle- and crust-derived melts. Zircons from a biotite-rich enclave define a protolith age of ca. 320 Ma and an anatectic age at ca. 281 Ma. Whole-rock Sr-Nd isotopic modelling and zircon Hf isotopes reveal that the batholith was mainly produced by remelting of newly accreted continental crust with minor addition of mantle-derived materials. The geochemical compositions imply that their precursor magmas originated from a relatively high crustal level (&lt;5 kbar) with crystallization temperatures ranging from 800 to 850°C. We suggest that the Daqing peraluminous granitoids were derived from partial melting of newly accreted crustal materials at a relatively shallow crustal depth, associated with a ridge subduction-related heat source. Such mantle-derived magmas through a slab tear window resulting from ridge subduction provide not only the heat for the widespread crustal remelting and therefore maturity but also juvenile materials for crustal growth.
Prediction of lymph node metastasis in early-stage triple-negative breast cancer based on a nomogram of clinicopathological parameters
Authors: Mao Ling , Zhu Chengjun , Xu Kun , Wang Cenzhu , Min Xuewen , Guan Xiaoxiang 
Published: March 2022

Abstract
Background: Triple-negative breast cancer (TNBC) is a relatively rare subtype of breast cancer, and is prone to lymph node metastasis at early stage. However, there is a lack of prognosis prediction models. The purpose of this study is to develop and validate an effective nomogram for predicting the probability of lymph node metastasis in early-stage TNBC.Methods: We selected 26,775 eligible patients who were diagnosed with early-stage TNBC between 2010 and 2015 from the Surveillance, Epidemiology, and End Results database. All the patients were randomly divided into a training cohort and a validation cohort at a 7:3 ratio. The 266 patients in the validation cohort comprised from the Affiliated Jurong Hospital of Jiangsu University for medical records from January 2011 to August 2020 to identify patients with histologically confirmed early-stage TNBC. The predictive accuracy and identification capability of the nomogram of the clinical prediction model were determined using the concordance index (C-index), receiver operating characteristic curves (ROC), and calibration curves.Results: In all, 27,041 patients were included, with 18,929 patients in the training cohort and 8,112 patients in the validation cohort. Multivariate analysis of the training cohort showed the independent risk factors for lymph node metastasis were age, race, primary site, histological type, grade and tumor size, which were all included in the nomogram. In the training cohort, the nomogram presented robust discrimination, with a C-index of 0.712, which was similar to the C-index of 0.710 in the validation cohort. Consistently, the area under the ROC curve was 0.712 in the training cohort and 0.710 in the validation cohort, which both showed good predictive value for lymph node metastasis risk. The calibration curve showed a better agreement between the nomogram-predicted probability and the actual probability of lymph node metastasis risk.Conclusions: The prognostic nomogram for early-stage TNBC patients constructed here shows good application prospect and can assist clinicians in predicting lymph lode metastasis in early-stage TNBC.
DNA repair byproduct 8-oxoguanine base promotes myogenic differentiation via OGG1-mediated activation of RAS-MEK-MyoD signaling pathway
Authors: Zheng Xu , Zhang Wenhe , Wu Jiaxin , Hu Yinchao , Zhang Xiaoqing , Hao Fengqi , Han Jinling , Hao Wenjing , Wang Ruoxi , Tian Meihong , Radak Zsolt , Nakabeppu Yusaku , Boldogh Istvan , Ba Xueqing 
Published: March 2022

Abstract
During exercise, muscle contraction increases the level of reactive oxygen species (ROS), which has been acknowledged as key signaling entities in muscle remodeling and to underlie the healthy adaptation of skeletal muscle. ROS inevitably endows damage to genomic DNA of the myofibers, and DNA damage ought to be repaired to ensure the integrity and fidelity of genetic materials; yet, how DNA repair metabolites affect muscle remodeling remains elusive. Here, we demonstrated that exercise induces 8-oxo-7,8-dihydroguanine (8-oxoG) generation in nuclei of myofiber, which subsequently is repaired. In myoblasts, 8-oxoG functions as a signal messenger, triggering myogenic differentiation via activating RAS-MEK-MyoD signal axis. 8-OxoG glycosylae 1 (OGG1) silencing from cells or depletion from mice decreased Ras activation, ERK phosphorylation, MyoD transcriptional activation, myogenic regulatory factors gene (MRFs) expression and consequently myogenic differentiation of myoblasts. Microscale Thermophoresis (MST) assay showed high affinity of 8-OxoG binding with OGG1, the complex functions as guanine nucleotide exchange factor (GEF) to activate Ras. In reconstruction experiments, exogenously added 8-oxoG base increases in the expression of MRFs and accelerates recovery of the injured skeletal muscle. Collectively, these data not only suggest that DNA repair metabolite 8-oxoG function as a signal entity for muscle remodeling and contribute to exercise-induced adaptation of skeletal muscle, but also pave the way for utilizing 8-oxoG in clinical treatment to skeletal muscle damage-related disorders.