bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examination of Key Genes in Angiogenesis of Breast and Prostate Cancers, in the Context of Different Cell Types
Authors: Jariani Abbas , Kakroodi Setareh Talebi , Arabfard Masoud , Rahimi Maryam 
Published: June 2022

Abstract
Background
The meaning of angiogenesis is the development of new blood vessels. Chemical signals start this process in the body. This will continue by migration, growth, and differentiation of endothelial cells, which line the inside wall of blood vessels. This process is vital for cancer cells.
Material and methods
Here, we investigated expression pattern of angiogenesis related genes in the context of previously published single-cell RNA-Seq data from prostate and breast cancer samples.
Results
Here we show how different modules of these angiogenesis related genes are over-expressed in different cell types, using protein-protein interaction network.
Conclusion
Our work demonstrates how different biological processes in distinct cell types that collaborate to the angiogenesis process, and can provide clues targeted inhibition of angiogenesis process.
Welfare implications of border carbon adjustments on the trade of harvested wood products
Authors: Liao Xinxin , Ning Zhuo 
Published: June 2022

Abstract
Background: Border Carbon Adjustments (BCAs) are designed to regulate carbon emissions and reduce carbon leakage. So far, BCAs are mainly applied for imported carbon-intensive products. On the other hand, harvested wood products (HWPs) are the extension of forest carbon stocks, whose changes affect a country’s carbon stock level. Nonetheless, the trade of HWPs also raises the problem of carbon leakage when their carbon stocks are exported, which can be partially solved by applying export BCAs.Result: By constructing a two-stage game, governments’ and forestry companies’ strategies under BCAs are analyzed. The government imposes BCAs on exports of HWPs when the carbon stock value exceeds a threshold. Moreover, the export BCAs on HWPs can effectively reduce the amount of HWPs exported. The results also show that BCAs diminish forestry exporters’ revenues and consumer surplus while having no significant detrimental impact on a country’s welfare.Conclusion: BCAs help include carbon stock values into HWPs’ prices and reduce carbon leakage, so they are beneficial for climate change. Thus, exporting countries can maintain their welfare by implementing BCAs, and the affected forestry companies can effectively cope with BCAs by improving the utilization efficiency of raw materials and their product quality.
Benzoic Acid Inclusion Effects on Health Status and Growth Performance of White Shrimp Juveniles Penaeus Vannamei
Authors: Loya-Rodríguez Mariany , Palacios-González Daniel Alberto , Lozano Rodolfo Olvera , Rodríguez Irma Eugenia Martínez , Puello-Cruz Ana Carmela 
Published: June 2022

Abstract
During the last decade, organic acids (OA) and their salts have been used as additives in aquafeed to increased nutritional values due their participation in some metabolic pathways and energy generation in organisms. Benzoic acid (BA) is one of the most used for its properties as a fungal growth inhibitor. It is used as a preserver in a wide variety of human consumption products included wine. Additionally, is also demonstrates health and growth benefits when its included in chickens, turkeys, cattle, and pig diets by modifying the energy metabolism and the microbiota and intestinal tract morphology. There is scarce information of BA inclusion in aquafeed and is non-existent in white shrimp, P. vannamei. This study evaluated the effects on growth, survival, feed conversion rate (FCR), energy content, and health status, through lipid quantification in hepatopancreas, histological analysis, and saline stress tests of white shrimp juveniles (Penaeus vannamei) by including BA at different concentrations (C0:0, C1:1.0, C2:1.5, and C3:2 g kg− 1) in a commercial feed. Increased BA inclusion presented significant differences (p ˂ 0.05) in the hepatosomatic index (Initial: 4.51 ± 0.65, C0: 4.01 ± 0.92, C1: 3.44 ± 1.68, C2: 2.37 ± 0.84, C3: 3.18 ± 1.60), hepatopancreas lipid content (Initial: 402.02 ± 48.76, C0: 293.48 ± 22.30, C1: 229.15 ± 11.46, C2: 136.69 ± 20.50, C3; 88.44 ± 6.19 mg g− 1) and histopathological damage in all BA concentrations. The lowest survival was 94.44% in C1. The FCR is within the ranges registered by the FAO except for that obtained in the C0. Calorimetric analysis and BA detection in muscle revealed no significant differences between concentrations. Due to the results obtained, the evaluated inclusions of BA in juvenile white shrimp (P. vannamei) diets are not recommended.
Understanding of Forces between Atomic Particles by Introduction of a New Particle Type in Space
Authors: Saha Ashim 
Published: June 2022

Abstract
In this paper it has been studied how does forces act between stable atomic particles. To do the findings it has been postulated that a tiny particle type is running throughout the space with some constant velocity. The particle of that type is so tiny that those particles almost don’t collide with each other and hence at any point in space if a solid atomic particle is being kept then the pressure on that atomic particle from all angles are same. However, if a second atomic particle is being brought closer to that former atomic particle, then shadows form on both atomic particles by each other atomic particles. Hence, pressure difference happens, and attraction force is being perceived. Also, it has been postulated that all atomic particles are made of this tiny particle type. As atomic particle spins it scatters those tiny particle and repulsive force is being perceived. In this paper this postulate has been verified mathematically and finally arrived at a formula of net force acting between two stable atomic particles. This mathematical model is successfully predicting change pattern of atomic radius with change in atomic numbers. Also, it is conforming that velocity of light is constant. This same model matches the Lennard-Jones potential function pattern between two atoms.
Case Report: Successful treatment with Dolutegravir containing antiretroviral therapy for acute on chronic liver failure by HBV in patients with HIV infection
Authors: Bi Mingyuan , Liu Yushen , Kang Wenzhen , Sun Yongtao , Kang Wen 
Published: June 2022

Abstract
Background: There’s no clear antiretroviral treatment for HIV/HBV co-infected patients with acute-on-chronic liver failure (ACLF) because of the vast majority of antiretroviral medications have hepatotoxicity. In this case report, we described two HIV/HBV co-infected ACLF patients treated with HAART regimen containing Dolutegravir (DTG) and successfully achieved symptom relief and viral suppression.Results: Two cases of HIV/HBV coinfection with ACLF who attempted to receive HAART containing DTG and were successfully treated without liver damage, immune reconstitution inflammatory syndrome (IRIS) or other complications occurred. Conclusions: It is proved that the application of DTG in HIV/HBV co-infected patients with ACLF has certain safety, which provides certain clinical basis for future prospective studies.
Multimodal personalized recommender algorithm based on knowledge graph
Authors: Walinder Lenart , Price Maynard , Lim Breda , Smith Burnet 
Published: June 2022

Abstract
An effective recommendation system can not only increase the stickiness of platform users, but also the traffic brought by user conversion and retention can significantly increase the revenue of the video platform. Current recommendation systems enable recommendations between text, images, audio, and video, pre-tagging different media files to generate different tags, and then searching for user-requested content through search engines. However, with the development of video platforms, users' personalized needs are getting stronger and more complex recommendation scenarios, and the accuracy of video recommendations is becoming more and more demanding. Compared with the structured data in traditional databases, multimedia data is characterized by large dimensionality, rich data content, and the large storage space required for the data. Multimedia data contains information of multiple modalities, i.e., text, image, and audio. Although there are some works that analyze the content of videos, these works only consider the unimodal data of videos. In this paper, we will explore how to use multimodal techniques and knowledge graphs to enhance user representations, and try to extend the idea of multimodal feature learning to existing knowledge graphs recommendation algorithms.
Complete Chloroplast Genome Sequence from Rosa lucieae and Its Characteristics
Authors: Shen Weixiang , Dong Zhanghong , Zhao Wenzhi , Ma Luyao , Wang Fei , Li Weiying , Xin Peiyao 
Published: June 2022

Abstract
Rosa lucieae Franch. & Rochebr. ex Crép. is one of the famous wild ancestors of cultivated roses and plays a very important role in horticultural research, but there is still a lack of research on the R. lucieae chloroplast genome. In this study, we used the Illumina MiSeq sequencing platform for sequencing, assembly and annotation to obtain the sequence information for the R. lucieae chloroplast genome and compared genomics, selection 1 stress analysis, and phylogenetic analysis with 12 other chloroplast genomes of Rosa. The R. lucieae cpDNA sequence has a total length of 156,504 bp and 130 genes are annotated. The length of all 13 studied chloroplast genomes is 156,333~157,385 bp. Their gene content, gene sequence, GC content and IR boundary structure were highly similar. Five kinds of large repeats were detected that numbered 100~116, and SSR sequences ranged from 78 to 90 bp. Four highly differentiated regions were identified, which can be used as potential genetic markers for Rosa. Selection stress analysis showed that there was significant positive selection among the 18 genes. The phylogenetic analysis of R. lucieae and R. cymose, R. maximowicziana, R. multiflora, and R. pricei showed the closest relationship. Overall, our results provide a more comprehensive understanding of the systematic genomics and comparative genomics of Rosa.
Pain adverse events, Bell’s palsy, and Guillain-Barré syndrome Following Vaccination
Authors: Ricke Darrell O. 
Published: June 2022

Abstract
Some individuals (vaccinees) experience pain related adverse events following vaccinations. The majority of vaccination reactogenicity adverse events resolve within days. Rare adverse events like Bell’s palsy and Guillain-Barré syndrome (GBS) have been associated with some vaccines. Herein, multiple working hypotheses are examined in the context of datamining results of the Vaccine Adverse Event System (VAERS) database. Observed onset occurrences of examined pain associated adverse events are consistent with likely etiology relationship with innate immune responses to vaccinations for multiple vaccines including SARS-CoV-2 COVID-19, influenza, and additional vaccines. Innate immune responses may be contributing to the initial etiology of Bell’s palsy and GBS post SARS-CoV-2 mRNA and adenoviral vaccinations.
Allometric relations between DBH and sapwood area for predicting stand transpiration: Lessons learned from the Quercus genus
Authors: Schoppach Rémy , Chun Kwok Pan , Klaus Julian 
Published: June 2022

Abstract
Catchment-scale transpiration is commonly determined by the use of sap-flow sensors, and its quantification, which is critical for water and forest management, relies crucially on the total catchment’s sapwood area (As). Species-specific allometric relationships between the trees As and the trees diameter at breast height (DBH) are widely used for determining stand or catchment As. However, substantial differences between studies challenged the robustness of these relationships between sites displaying various topographical and environmental characteristics. In this study, we aim at comparing these relationships between species of the Quercus genus from sites in different parts of the world, and testing the role of topographical factors on As-DBH relationship in Quercus petraea. Using 145 trees sampled within a 0.455 km² catchment, we showed that topography (slope, flow accumulation, aspect, curvature, topographic wetness index) does not modulate the As-DBH relationship in Quercus petraea, within our catchment. We compared our curve parameters with the ones from 17 studies on oak trees and found that the As-DBH relationship is not only species-specific, but depends on the site’s conditions, and likely the stand density, the total radiation and the evaporative demand. In the light of these results, we recommend to build site- and species-specific As-DBH relationship for determining stand transpiration, using a minimum of nine, randomly sampled trees, and different methods and azimuthal directions for determining sapwood depth.
How Does the Codified Knowledge Relatedness Influence Foreign Intelligence Import in Emerging Countries: Evidence from Chinese PCT Activities
Authors: Zhou Hao , Lin Jie 
Published: June 2022

Abstract
With the accelerated evolution of the global innovation pattern, the micro-foundation of the participation of emerging countries’ innovation subjects in the global ‘war for talent’ has gradually become the focus of relevant studies. Based on the perspective of citation coupling, this study uses the bibliographic-patent-coupling (BPC) indicators between 214 innovation subjects owned by 96 popular innovative organisations in China and 431 overseas regions with patent cooperation treaty (PCT) activity records to describe the bilateral codified knowledge (CK) relatedness and examine its impact on the allocation of overseas PCT inventors by Chinese innovation subjects. The results show that the BPC relationship significantly increases the scale of Chinese innovation subjects’ intelligence import from overseas regions, especially the regions with rapid innovation. The effect of the BPC relationship on increasing the foreign intelligence import scale of innovation subjects is positively affected by the quality of the patents jointly cited by both parties. The study further finds that the heterogeneity of innovation subjects can affect the effect of foreign intelligence import on BPC strength. Finally, the tacit knowledge (TK) relatedness at the geographic and organisational levels can promote the import of foreign intelligence of innovation subjects and have a coordinated effect on the BPC relationship. This coordinated effect mainly exists in high-quality innovation activities driven by enterprise innovation subjects.
Quality of Life in patients with Filum Disease and Neuro-cranio-vertebral Syndrome with Arnold-Chiari Syndrome Type I, Idiopathic Syringomyelia, Idiopathic Scoliosis
Authors: Royo-Salvador Miguel B. , Luè Gioia 
Published: June 2022

Abstract
Filum disease and Neuro-cranio-vertebral syndrome are two pathological concepts that comprise various diseases. Our objectives are to describe their neuro-psychological alterations, and to conduct a descriptive analysis of how these diagnoses can influence Quality of Life. We conducted a retrospective, descriptive study of the clinical anamneses of patients diagnosed with Filum disease from a sample of 372 randomly selected patients in relation to their Quality of Life. We also analysed the self-reported psychological-emotional health in 34 other patients. Mood alterations and cognitive and sexual dysfunction may also be affected in these pathologies. Filum disease deteriorates Quality of Life and affects perceived Quality of Life. Many patients report how the gradual worsening of symptoms affects the self-assessment and self-perception of their own physical and psychological health, influencing their expectations in various areas of life. Quality of Life can be affected by limited physical condition, headaches, pain, instability, lack of sensitivity or strength, or paresis. The consequences that Filum disease can have on environmental and social context correspond to a further decrease in Quality of Life. For the diagnosis, prognosis, treatment, and post-operative evaluation, it is essential to consider everything reported in the initial anamnesis.
KOMPARASI PERKEMBANGAN POTENSI ANAK USIA DINI MENURUT ISLAM DENGAN TEORI KOHLBERG
Authors: Bahri Saiful 
Published: June 2022

Abstrak: Kohlberg sangat memperdulikan perkembangan manusia, sehingga dia mengemukakan tiga tahapan perkembangan potensi manusia, sedangkan Islam sebagai agama yang rahmatan lil ‘alamiin sangat memperdulikan perkembangan manusia, sehingga mengemukakan konsep tentang perkembangan tersebut dalam hadits dan al-Qur’an. Persamaan antara kedua teori tersebut adalah sama-sama mengungkapkan tahapan-tahapan perkembangan anak dan perkembangan potensi anak. Kemudian juga mengungkapkan tahapan pendidikan yang harus dilaksanakan kepada anak supaya anak dapat berkembang sesuai dengan bakat alaminya. Perbedaannya mulai dari perbedaan epistemologi dan juga perbedaan pengembangan konsep fitrah.

Kata kunci: Potensi Anak Usia Dini, Teori Kohlberg
Abstract: Kohlberg really cares about human development, so he put forward three stages of human potential development, while Islam as a religion which is rahmatan lil 'alamin really cares about human development, so he put forward the concept of this development in the hadith and the Qur'an. The similarities between the two theories are that they both reveal the stages of child development and the development of children's potential. Then also reveal the stages of education that must be carried out to children so that children can develop according to their natural talents. The differences start from differences in epistemology and also differences in the development of the concept of fitrah.

Keywords: Early Childhood Potential, Kohlberg's Theory
Influence of Front-Desk Staff Service Quality on Students’ Affective Commitment, Trust, and Word-of-Mouth in Higher Education
Authors: Muhammad Asif Qureshi  , Syed Ali Raza  , Ishtiaq Ahmed Kolachi  , Areeba Sarwar  , Komal Akram Khan  
Published: June 2022

Private universities are growing in the present era. The enrollment ratio is also getting high, and universities are putting efforts to attract more students. Hence, it is essential to provide students with the best quality services as it spreads positive word-of-mouth. Therefore, the present article is designed to study the impact of front-desk staff service quality on word-of-mouth through the mediating effect of students’ affective commitment and students’ trust. An online questionnaire survey was conducted in Karachi, Pakistan. This study used the partial least square method to run structural equation modeling analysis. The findings revealed that all paths show a positive and significant relationship except front-desk staff service quality and word-of-mouth. Moreover, students’ affective commitment and trust mediate the relationship between front-desk staff service quality and word-of-mouth. Results also illustrate that gender exerts a significant moderating role on front-desk staff service quality, students’ affective commitment, and word-of-mouth. The study provides practical implications for policymakers, private university management, and educational institutions. Firstly, it is crucial to provide effective communication training to the front-desk staff to learn the basic etiquette of greetings and humbleness. Secondly, there must be experienced personnel who can assist students promptly.
Atomistic insight into the ferroelastic post-stishovite transition by high-pressure single-crystal X-ray diffraction
Authors: Zhang Yanyao , Chariton Stella , He Jiaming , Fu Suyu , Xu Fang , Prakapenka Vitali B. , Lin Jung-Fu 
Published: June 2022

Abstract
The post-stishovite transition is a classic pseudo-proper typed ferroelastic transition with a symmetry-breaking spontaneous strain. This transition has been studied using high-pressure spontaneous strains, optic modes, and elastic moduli (Cij) based on the Landau modeling, but its atomistic information and structural distortion remain poorly understood. Here we have conducted synchrotron single-crystal X-ray diffraction measurements on stishovite crystals up to 75.3 GPa in a diamond-anvil cell. Analysis of the data reveals atomic positions, bond lengths, bond angles, and variations of SiO6 octahedra across the transition at high pressure. Our results show that the O coordinates split at ~51.4 GPa, where the apical and equatorial Si-O bond lengths cross over, the SiO6 octahedral distortion vanishes, and the SiO6 octahedra start to rotate about the c axis. Moreover, distortion mode analysis shows that an in-plane stretching distortion (GM1+ mode) occurs in the stishovite structure at high pressure while a rotational distortion (GM2+ mode) becomes dominant in the post-stishovite structure. These results are used to correlate with elastic moduli and Landau parameters (symmetry-breaking strain e1–e2 and order parameter Q) to provide atomistic insight into the ferroelastic transition. When the bond lengths of two Si-O bonds are equal due to the contribution from the GM1+ stretching mode, C11 converges with C12, and the shear wave VS1[110] polarizing along [110] and propagating along [110] vanishes. Values of e1–e2 and Q are proportional to the SiO6 rotation angle from the occurrence of the GM1+ rotational mode in the post-stishovite structure. Our results on the pseudo-proper type transition are also compared with that for the proper type in albite and improper type in CaSiO3 perovskite. The symmetry-breaking strain, in all these types of transitions, arises as the primary effect from the structural angle (such as SiO6 rotation or lattice constant angle) and its relevant distortion mode in the low-symmetry ferroelastic phase.
Detailed experimental and numerical analysis of hydrodynamics in the outflow measurement channel of a sewage treatment plant
Authors: Ragessi I. Matias , García Carlos Marcelo , Damian Santiago Marquez , Tarrab Leticia , Patalano Antoine , Rodriguez Andres 
Published: June 2022

Abstract
The ‘Bajo Grande’ Wastewater Treatment Plant has a design capacity of 2.78 m3/s, and discharges into the Suquia River (Córdoba, Argentina). The river has an average flow rate of 10 m3/s, with lower values during the summer. Currently, the treatment plant does not have an accurate discharge-measurement system prior to the discharge into the river, which makes it difficult to evaluate the dosing of the disinfection treatment. The outflow rate is measured in a straight flume. However, at the inlet section of the flume, a 180° sharp bend induces a complex turbulent flow with instabilities and low-frequency velocity fluctuations which are not appropriate for flow quantification. In this type of flow, most of the in situ flow discharge-measurement systems have great uncertainty. Therefore, in situ flow measurements with an Acoustic Doppler Current Profiler, Large-Scale Particle-Tracking Velocimetry techniques and a prototype-scale Detached Eddy Simulation model were combined to obtain a detailed characterization of the turbulent flow. The results provide flow rates, fields of mean flow velocity, temporal evolution, and characteristic parameters of the turbulence. This allowed a better understanding of the effects of turbulence and flow instabilities. The results provide a basis to validate numerical models used in the hydraulics design of contact chambers to improve the disinfection process.
Crystal-State Structure of the C-Terminal Pentapeptide of the Antibiotic Efrapeptin C
Authors: Benedetti Ettore , Iacovino Rosa , Saviano Michele , Kamphuis Johan , Crisma Marco , Formaggio Fernando , Moretto Vittorio , Toniolo Claudio 
Published: June 2022

Abstract:
An X-ray diffraction analysis of the C-terrninal, fully block...d pentapeptide segment of the antibiotic efrapeptin C Z-L-Pip-Aib-Gly-L-Leu-Aib-NHMe monohydrate showed that its secondary structure is characterized by three non-helical -bend conformations located at the -L-Pip-Aib-, -Aib-Gly-, and -L-Leu-Aib- sequences, respectively .