bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a short-term water quality prediction model for urban rivers using real-time water quality data
Authors: Lee J. H. , Lee J. Y. , Lee M. H. , Lee M. Y. , Kim Y. W. , Hyung J. S. , Kim K. B. , Cha Y. K. , Koo J. Y. 
Published: February 2022

Abstract
We developed a classification model and a real-time prediction model for short-term dissolved oxygen (DO) at the junction of the Han River in Anyangcheon, where water quality accidents occur frequently. The classification model is an analysis model that derives the main factors affecting DO changes in the Anyangcheon mobile water quality monitoring network using decision tree, random forest, and XGBoost. The model identified the key factors affecting DO changes to be electrical conductivity, cumulative precipitation, total nitrogen, and water temperature. Random forest (sensitivity, 0.9962; accuracy, 0.9981) and XGBoost (sensitivity, 1.0000; accuracy, 0.9822) showed excellent classification performance. The real-time prediction model for short-term DO that we developed adopted artificial neural network (ANN), long short-term memory (LSTM), and gated recurrent unit (GRU) algorithms. LSTM (R2 = 0.93 − 0.97, first half; R2 = 0.95 − 0.96, second half) and GRU (R2 = 0.94 − 0.98, first half; R2 = 0.96 − 0.98, second half) significantly outperformed ANN (R2 = 0.64 − 0.86). The LSTM and GRU models we developed used real-time automatic measurement data, targeting urban rivers that are sensitive to water quality changes and are waterfront areas for citizens. They can quickly reflect and simulate short-term, real-time changes in water quality compared with existing static models.
Flood inundation maps using Sentinel-2: a case study in Berdan Plain
Authors: Güvel Şerife Pınar , Akgül Mehmet Ali , Aksu Hakan 
Published: February 2022

Abstract
This study assessed the performance of remote sensing and geographic information system techniques for analysing flood events in agricultural areas and estimating flooded areas in agricultural lands. The Berdan Plain in the southern part of Turkey is below sea level and prone to flood events. The flooded agricultural areas were estimated by using Sentinel-2 satellite data for the Berdan Irrigation Scheme from December 2019-January 2020. The flooded area in the old Aynaz marsh was estimated as 486.79 hectares on 9 January 2020, while the total flooded area in the Berdan Irrigation Project was 4,515.58 hectares. Flood volume was calculated as 2.61 hm3 and the highest water level was estimated to be −0.76 metres in the old Aynaz marsh.
Enhanced sequestration of molybdenum(VI) using composite constructed wetlands and responses of microbial communities
Authors: Chen B. , Zhou F. J. , Yang F. , Lian J. J. , Ye T. R. , Wu H. Y. , Wang L. M. , Song N. , Liu Y. Y. , Hui A. Y. 
Published: February 2022

Abstract
The molybdenum (Mo) non-point source pollution in the mining area has an irreversible impact on the surrounding water and soil ecosystems. Herein, three integrated vertical subsurface flow constructed wetlands (CWs) were constructed to assess the effects of combination substrates and plant on the removal of Mo(VI). Results showed that CW1 with combination substrates and cattail exhibited a favorable removal performance for Mo(VI) at 80.90%. Moreover, most Mo(VI) retained in the CWs was retained in the substrate (58.13–88.04%), and the largest fraction of Mo(VI) retained was the water-soluble fraction on the surface of the combination substrates. Mo(VI) removal was also influenced by the microbial community composition in substrate, especially their co-occurrence networks. The species that showed significant positive correlation with Mo(VI) removal were Planctomycetes, Latescibacteria, Armatimonadetes, and Gemmatimonadetes. Moreover, CWs added plants showed that more co-occurrences interaction between taxa occurs, which means that the wetlands efficiently select recruitment of potential microbial consortia and change the co-occurrences to remove pollution in the substrate. These results could be useful in providing an ecology-based solution for the treatment of Mo(VI) in wastewater, especially in adjusting the microbial communities for Mo(VI) removal at the genetic level.
Towards the long term implementation of real time control of combined sewer systems: a review of performance and influencing factors
Authors: van der Werf Job Augustijn , Kapelan Zoran , Langeveld Jeroen 
Published: February 2022

Abstract
Real Time Control (RTC) is widely accepted as a cost-effective way to operate urban drainage systems (UDS) effectively. However, what factors influence RTC efficacy and how this might change in the long term remains largely unknown. This paper reviews the literature to understand what these factors likely are, and how they can be assessed in the future. Despite decades of research, inconsistent definitions of the performance of RTC are used, hindering an objective and quantitative examination of the benefits and drawbacks of different control strategies with regard to their performance and robustness. Furthermore, a discussion on the changes occurring and projected to occur to UDS reveals that the potential impact of these changes on the functioning of RTC systems can be significant and should be considered in the design stage of the RTC strategy. Understanding this ‘best-before’ characteristic of an RTC strategy is the key step to ensure long term optimal functioning of the UDS. Additionally, unexplored potential for RTC systems might exist in the transitions, rehabilitation and construction of drainage systems. The research gaps highlighted here could guide the way for further development of RTC strategies, and enabling more optimal, long term implementation of RTC for urban drainage systems.
Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation
of Clozapine In vivo
Authors: Smith Robert Løvsletten , Wollmann Birgit M. , Kausberg Marianne , Mæland Sondre , Tveito Marit , O’Connell Kevin , Molden Espen , Kringen Marianne Kristiansen 
Published: February 2022

Background:
Glucuronidation is an important metabolic pathway of clozapine (CLZ), but the impact of
various uridine 5'diphospho-glucuronosyltransferases (UGT) polymorphisms on the exposure and metabolism of
CLZ in vivo is unclear.

Objective:
The objective of this study was to investigate the impact of UGT2B haplotype and UGT1A4*3 allele variants
on the formation of CLZ glucuronide metabolites (5N- and N+-glucuronide) and CLZ exposure in patients’ serum
after adjusting for sex, age, and smoking habits.

Methods:
The study was based on serum samples from CLZ-treated patients (n=79) subjected to routine therapeutic
drug monitoring (TDM) at Diakonhjemmet Hospital, Oslo, Norway. From the same patients, the following UGT
variants were genotyped using Real-Time PCR: UGT2B:GA haplotype (defined as UGT2B:GA; rs1513559A>G and
rs416593T>A) and UGT1A4*3 (rs2011425T>G). Serum concentrations of CLZ 5N- and N+-glucuronide were measured
by UPLC high-resolution mass spectrometry.

Results:
None of the genotypes had significant impact on CLZ exposure (p>0.05). However, compared to
UGT2B:AT/AT and UGT1A4*1/*1, the 5N-glucuronide exposure was reduced in UGT2B:GA/GA carriers (-75 %,
p=0.03) while the exposure was non-significantly increased in UGT1A4*3 carriers (+100 %, p=0.14), respectively.
The N+-glucuronide exposure was unchanged in UGT1A4*3 vs. noncarriers (p=0.28), but significantly reduced in
heterozygous (-50 %, p=0.016) and homozygous carriers (-70 %, p=0.021) of UGT2B:GA compared to
UGT2B:AT/AT carriers, respectively.

Conclusion:
The UGT2B:GA and UGT1A4*3 variants had no impact on CLZ exposure but were associated with
differences and preferences in CLZ glucuronidation. The latter might be of potential relevance for CLZ tolerability
since levels of the N+-glucuronide metabolite may reflect the generation and trapping of reactive metabolites involved
in CLZ-induced toxicity.
SARS-CoV-2 Infections, Impaired Tissue, and Metabolic Health: Pathophysiology and Potential Therapeutics
Authors: Singh Shailendra Pratap , Kanwal Abhinav , Amar Salomon , Bhatnagar Aayushi , Singh Sujeet Kumar , Patra Sanjib K. , Kanwar Navjot , Manna Ranata 
Published: February 2022

Abstract:
The SARS-CoV-2 enters the human airways and comes into contact with the mucous membranes lining the mouth, nose, and eyes. The virus enters the healthy cells and uses cell machinery to make several copies itself. Critically ill patients infected with SARS-CoV-2 may have damaged lungs, air sacs, lining, and walls. Since COVID-19 causes cytokine storm, it damages the alveolar cells of the lungs and fills them with fluid, making it harder to exchange oxygen and carbon dioxide. The SARS-CoV-2 infection causes a range of complications, including mild to critical breathing difficulties. It has been observed that older people suffering from health conditions like cardiomyopathies, nephropathies, metabolic syndrome, and diabetes instigate severe symptoms. Many people who died due to COVID-19 had impaired metabolic health [IMH], characterized by hypertension, dyslipidemia, and hyperglycemia, i.e., diabetes, cardiovascular system, and renal diseases, making their retrieval challenging. Jeopardy stresses for increased mortality from COVID-19 include older age, COPD, ischemic heart disease, diabetes mellitus, and immunosuppression. However, no targeted therapies are available as of now. Almost two-thirds of diagnosed coronavirus patients had cardiovascular diseases and diabetes, out of which 37% were under 60. The NHS audit revealed that with a higher expression of ACE-2 receptors, viral particles could easily bind their protein spikes and get inside the cells, finally causing COVID-19 infection. Hence, people with IMH are more prone to COVID-19 and, ultimately, comorbidities. This review provides enormous information about tissue [lungs, heart, and kidneys] damage, pathophysiological changes, and impaired metabolic health of SARS-CoV-2 infected patients. Moreover, it also designates the possible therapeutic targets of COVID-19 and drugs which can be used against these targets.
Impact of the Cannabinoid System in Alzheimer's Disease
Authors: Li Shuangtao , Huang Yuanbing , Yu Lijun , Ji Xiaoyu , Wu Jie 
Published: February 2022

Abstract:
Cannabinoids are compounds that were initially isolated from cannabis marihuana and are also widely present in both nervous and immune systems of animals. In recent years, with in-depth research on cannabinoids, their clinical medicinal value has been evaluated, and many exciting achievements have been continuously accumulating, especially in the field of neurodegenerative disease. Alzheimer's disease is the most common type of neurodegenerative disease that causes dementia and has become a global health problem that seriously impacts human health today. In this review, we discuss the therapeutic potential of cannabinoids for the treatment of Alzheimer’s disease. How cannabinoids act on different endocannabinoid receptor subtypes to regulate Alzheimer’s disease, the roles of the endocannabinoid system in Alzheimer’s disease are outlined, and the underlying mechanisms are discussed. Finally, we summarize the most relevant opportunities of cannabinoid pharmacology related to Alzheimer’s disease and discuss the potential usefulness of cannabinoids in the clinical treatment of Alzheimer’s disease.
Galectin-3 in Microglia-Mediated Neuroinflammation: Implications for
Central Nervous System Diseases
Authors: Tian Yu-Ke , Ye Da-Wei , Ge Meng-Meng , Chen Nan , Zhou Ya-Qun , Yang Hui 
Published: February 2022

Abstract:
Microglial activation is one of the common hallmarks shared by various central nervous
system (CNS) diseases. Based on surrounding circumstances, activated microglia play either detrimental
or neuroprotective effects. Galectin-3 (Gal-3), a group of β-galactoside-binding proteins, has
been cumulatively revealed to be a crucial biomarker for microglial activation after injuries or diseases.
In consideration of the important role of Gal-3 in the regulation of microglial activation, it
might be a potential target for the treatment of CNS diseases. Recently, Gal-3 expression has been
extensively investigated in numerous pathological processes as a mediator of neuroinflammation, as
well as in cell proliferation. However, the underlying mechanisms of Gal-3 involved in microgliamediated
neuroinflammation in various CNS diseases remain to be further investigated. Moreover,
several clinical studies support that the levels of Gal-3 are increased in the serum or cerebrospinal
fluid of patients with CNS diseases. Thus, we summarized the roles and underlying mechanisms of
Gal-3 in activated microglia, thus providing a better insight into its complexity expression pattern,
and contrasting functions in CNS diseases.
A Review of Functional Values of Melon Seeds
Authors: Kumar Akash , Jangra Aarzoo , Pramanik Jhilam 
Published: February 2022

Abstract:
Wastage of food is a big concern for the world. In summers, several fruits are
available like watermelon, muskmelon, etc. Muskmelons are fruits that are consumed all over the
world. Around 32 % of muskmelon is wasted; it includes 5 % seeds and 27 % peel of the total
weight. Seeds of muskmelons have great nutritional benefits. They have a very large number of
bioactive compounds like tocopherols, phospholipids, and sterols. Muskmelon seeds have
antimicrobial, anti-inflammatory, antioxidant, antidiabetic, anti-Alzheimer, and diuretic
properties and can be used to treat or prevent many diseases. Therefore, muskmelon seeds can be
used as a functional food.
Amplified Listening to Race and Gender in Fiamma Montezemolo’s "Echo" and Stephanie Dinkins’s "N’TOO"
Authors: Klassen Lois , Aceves Sepúlveda Gabriela 
Published: February 2022

Looking retrospectively and prospectively, this article reflects on what is heard when listening to the women talking inside artworks. Both Echo (2014) by Fiamma Montezemolo and Not the Only One (N’TOO), an ongoing project by Stephanie Dinkins, present sound archives that animate spaces with fragments of dissenting women’s voices. Looking back at the impact of inSITE, a curated international art festival in the Tijuana and San Diego region, Echo amplifies the sonic remains of art produced in the context of NAFTA. In N’TOO a living AI archive is potentiated as a fourth generation in the artist’s family, carrying on the histories and subjectivities of three women. N’TOO optimistically intervenes in AI’s expansionist and biased trajectories by furthering Black and familial subjectivity in a specific context of racial and gender foreclosures. Despite their spare use of sound, both artworks enable amplified listening through the avatar-like objecthood afforded by gallery-based media artworks. This methodology is consistent with decolonizing efforts in Canada and has significance for artists intervening in intersectional, race, and gender studies, border studies, and in settings of computational or interactive technology.
Web-Based Patient Educational Material on Osteosarcoma: Quantitative Assessment of Readability and Understandability
Authors: Gulbrandsen Trevor Robert , Skalitzky Mary Kate , Shamrock Alan Gregory , Gao Burke , Hasan Obada , Miller Benjamin James 
Published: February 2022

Background
Patients often turn to web-based resources following the diagnosis of osteosarcoma. To be fully understood by average American adults, the American Medical Association (AMA) and National Institutes of Health (NIH) recommend web-based health information to be written at a 6th grade level or lower. Previous analyses of osteosarcoma resources have not measured whether text is written such that readers can process key information (understandability) or identify available actions to take (actionability). The Patient Education Materials Assessment Tool (PEMAT) is a validated measurement of understandability and actionability.

Objective
The purpose of this study was to evaluate web-based osteosarcoma resources using measures of readability, understandability, and actionability.

Methods
Using the search term “osteosarcoma,” two independent Google searches were performed on March 7, 2020 (by AGS), and March 11, 2020 (by TRG). The top 50 results were collected. Websites were included if they were directed at providing patient education on osteosarcoma. Readability was quantified using validated algorithms: Flesh-Kincaid Grade Ease (FKGE), Flesch-Kincaid Grade-Level (FKGL). A higher FKGE score indicates that the material is easier to read. All other readability scores represent the US school grade level. Two independent PEMAT assessments were performed with independent scores assigned for both understandability and actionability. A PEMAT score of 70% or below is considered poorly understandable or poorly actionable. Statistical significance was defined as P≤.05.

Results
Two searches yielded 53 unique websites, of which 37 (70%) met the inclusion criteria. The mean FKGE and FKGL scores were 40.8 (SD 13.6) and 12.0 (SD 2.4), respectively. No website scored within the acceptable NIH or AHA recommended reading level. Only 4 (11%) and 1 (3%) website met the acceptable understandability and actionability threshold. Both understandability and actionability were positively correlated with FKGE (ρ=0.55, P<.001; ρ=0.60, P<.001), but were otherwise not significantly associated with other readability scores. There were no associations between readability (P=.15), understandability (P=.20), or actionability (P=.31) scores and Google rank.

Conclusions
Overall, web-based osteosarcoma patient educational materials scored poorly with respect to readability, understandability, and actionability. None of the web-based resources scored at the recommended reading level. Only 4 achieved the appropriate score to be considered understandable by the general public. Authors of patient resources should incorporate PEMAT and readability criteria to improve web-based resources to support patient understanding.
Surfing The New Wave: International Women’s Year and the Geopolitics of 1970s Mexican Feminism
Authors: Olcott Jocelyn 
Published: February 2022

Although scholars and activists point to the 1975 International Women’s Year Conference as a pivotal moment in the development of transnational feminist networks, there has been less attention paid to the importance of its taking place in Mexico City. This article explores how the “new wave” of Mexican feminism in the early 1970s shaped policy priorities within Mexico as well as how the geopolitical context informed the range of possibilities open to feminist activists. As Mexican President Luis Echeverría pursued recognition on the international stage, he sought to align Mexicanpolicies with UN priorities around population control and women’s opportunities.
Beyond Borders: Uncertainty in Supragovernmental Tax Enforcement and Corporate Investment
Authors: Fox Zackery D. , Jacob Martin , Wilde Jaron H. , Wilson Ryan J. 
Published: February 2022

ABSTRACT
Amid growing globalization, many countries have offered tax incentives to attract corporate investment. Prior research studies the role such incentives play in firms' location and investment choices. However, we have limited evidence regarding the role that uncertainty about the intensity of future tax enforcement plays in those decisions. In 2013, the European Commission (E.C.) abruptly began investigating the tax-ruling practices of several countries in response to allegations that certain firms received preferential tax treatment (“state aid cases”). We use this setting to study the economic consequences of increased uncertainty about future tax enforcement. We find evidence consistent with significant reductions in U.S. multinational enterprises' subsidiary investments within, firm input purchases from, and aggregate investment of U.S. firms flowing to targeted state aid countries. Specifically, for U.S. multinational enterprises' subsidiary investments, we find fixed assets declined by 1.7 percent of total assets, or $7.6 million per subsidiary.
JEL Classifications: M41; M48; H25; H26.
The Impact of Motivation and Environment on Employee Performance with Organizational Commitment as Intervening Variable
Authors: Frastika Adelfigita , Franksiska Rosaly 
Published: February 2022

Employee performance is the result achieved by the employee in completing the work assigned by the company to the employee. The inconsistencies of previous research and also overlooking the chance that organizational commitment may act as intervening variable is the problem that this research highlight. The purpose of the study was to test the effect of work motivation and work environment on employee performance with organizational commitment as an intervening variable. This type of research is causal-quantitative research. Saturation sampling was used in this research. 110 employees of PT Abioso Batara Alba, Boyolali Regency, as the sample. Data collection techniques in this study using a questionnaire. The hypothesis testing technique is in the form of path analysis using SPSS version 20 and the Sobel test. The results showed that work motivation had an effect on employee performance. Organizational commitment does not mediate the effect of work motivation on employee performance. Good work motivation will increase employee performance. The work environment has an effect on employee performance. Organizational commitment does not mediate the effect of the work environment on employee performance. Employee performance will improve if they are motivated at work. Employees do not need to be devoted to the firm to increase performance because the company's good work motivation will directly improve employee performance. Employees do not need to be dedicated to the company first in order for the construction of a nice work environment to have a direct impact on employee performance.
Independent Learning through Interactive Multimedia Based on Problem Based Learning
Authors: Arifin Zainul , Tegeh I Made , Yuda Sukmana Adrianus I Wayan Ilia 
Published: February 2022

Penelitian ini didasari kurangnya penggunaan media pembelajaran yang kreatif dan interaktif. Hal ini berdampak pada hasil belajar peserta didik. Penelitian ini bertujuan untuk mendeskripsikan proses pengembangan multimedia pembelajaran interaktif. Penelitian pengembangan ini menggunakan model pengembangan ADDIE. Subjek penelitian pengembangan ini yaitu 1 ahli isi mata pelajaran, 1 ahli desain pembelajaran, 1 ahli media pembelajaran, 3 siswa untuk uji perorangan, dan 9 siswa untuk uji kelompok kecil. Metode pengumpulan data yang digunakan dalam penelitian pengembangan ini yaitu metode wawancara, metode observasi, dan metode kuesioner. Instrumen yang digunakan untuk mengumpulkan data yaitu kuesioner. Teknik yang digunakan untuk menganalisis data yaitu analisis deskriptif kualitatif dan kuantitatif. Hasil penelitian pengembangan ini multimedia pembelajaran interaktif ini dinyatakan valid dengan hasil review ahli isi mata pelajaran sebesar 98,46% dengan kualifikasi sangat baik. Hasil review ahli desain pembelajaran sebesar 92 % dengan kualifikasi sangat baik. Hasil review ahli media pembelajaran sebesar 92,72% dengan kualifikasi sangat baik. Hasil review dari uji perorangan sebesar 95% dengan kualifikasi sangat baik. Hasil review dari uji kelompok kecil sebesar 95,17% dengan kualifikasi sangat baik. Multimedia pembelajaran interaktif berbasis model pembelajaran problem-based learning (PBL) layak digunakan untuk proses pembelajaran.