bluuebunny/crossref_metadata_2025_split huggingface dataset:
Menopause-dependent correlations of blood mercury levels with bone mineral density and appendicular lean mass index in middle-aged women
Authors: Xu Feng , Wang Yanfei , Fang Jinqiong , Zhu Zhongxin 
Published: February 2025

BackgroundMercury exposure poses significant health risks, yet its effects on bone mineral density (BMD) and appendicular lean mass index (ALMI) in middle-aged women remain poorly understood. This study aimed to investigate the associations between blood mercury levels (BML) and these key indicators of skeletal health and body composition, with special attention to the potential modifying effect of menopausal status.MethodsWe analyzed data from 1,648 women aged 40–59 years (782 premenopausal, 866 postmenopausal) using the National Health and Nutrition Examination Survey (NHANES) 2011–2018. Multiple linear regression models were employed to assess the relationships between LnBML and both lumbar BMD and ALMI, adjusting for relevant covariates.ResultsThere was complex, non-linear associations between LnBML and skeletal health parameters. Notably, the relationship between LnBML and lumbar BMD differed significantly based on menopausal status (P for interaction &lt;0.001). In premenopausal women, LnBML was negatively associated with BMD (β = −0.018, 95% CI: −0.029, −0.007), while in postmenopausal women, a positive association was observed (β = 0.025, 95% CI: 0.014, 0.036). Conversely, LnBML demonstrated a significant positive association with ALMI (β = 0.054, 95% CI: 0.025, 0.083, p &lt; 0.001) in the fully adjusted model.ConclusionOur findings revealed intricate, menopause-dependent relationships between BML and skeletal health parameters in middle-aged women. These results underscore the complex interplay between environmental exposures and women’s health across the menopausal transition, highlighting the need for further research to elucidate underlying mechanisms and inform targeted interventions.
Impact of Omicron infection on childhood health: the Beijing long-COVID study
Authors: Zhou Bo , Xu Qi , Li Shaoli , Wang Jianhong , Liu Junting , Zhang Ting , Qu Xia , Wang Xi , Zhang Lili , Liu Xiaoli , Gu Jialu , Zhou Lijun , Chen Fangfang , Zong Xinnan , Niu Wenquan , Wang Lin 
Published: February 2025

PurposeThe aim of this prospective study was to assess the dynamic changes of persisting symptoms among children aged 6–18 years during 1–2 months after the Omicron infection based on the modified SBQ-LC in the Tongzhou cohort, Beijing.MethodsThis study includes 4 serial surveys performed within January 7–9, January 14–16, January 21–23, and February 12–14 in 2023, respectively. The prediction of age and survey for eight domains in the Rasch 0–100 linear score was undertaken by generalized additive mixed model.ResultsTotal 1,536 children (median age: 13 years, boys: 49.9%) had completed questionnaires across 4 surveys. Information on 51 symptoms was collected, with each scored on a 4-point rating scale. Generally, the distribution of age with all domains followed the N-shaped geometry, and that of survey followed the inverse J-shaped geometry. The Rasch linear score hit the lowest level among children aged 6–8 years, and reached the peak among children aged 12–13 years. The scores of all domains sharply declined from the first to the third survey, and remained stable between the third and the fourth survey. At the fourth survey, 95.05 and 51.37% children still had one or more problems relating to breathing and mental health, respectively, and the percentage of rest six domains was reduced to less than 20%.ConclusionOur findings indicate the multifaceted impact of Omicron infection on childhood health, especially among children aged 12–13 years. Moreover, breathing and mental health related problems still persisted during 1-to-2-month Omicron infection period.
Determining the impact of the COVID-19 pandemic on the consumption of antibiotics in Shaanxi province, China: an interrupted time-series analysis
Authors: Ji Wenjing , Zhao Yifei , Du Jiaxi , Zhao Hang , McIver David J. , Ye Dan , Yan Kangkang , Wei Xiaolin , Fang Yu 
Published: February 2025

BackgroundThe COVID-19 pandemic, as well as associated prevention and control measures, have impacted the entire healthcare system, including the use patterns of medicine. However, the impact of COVID-19 on the use of antibiotics has not yet been extensively evaluated in China. This study aimed to evaluate the impact of the pandemic on the consumption and expenditure of antibiotics in public healthcare institutions in Shaanxi Province, China.MethodsWe used longitudinal data from the Shaanxi provincial drug procurement database in this study. An interrupted time-series analysis was performed to evaluate the effects of COVID-19 on consumption and expenditures of antibiotics in public healthcare institutions in Shaanxi from 1 January 2017 to 31 December 2020. Antibiotic consumption was expressed as the number of defined daily doses (DDDs) per 1,000 residents per day (DIDs), based on the population of Shaanxi Province at the end of each year from the National Bureau of Statistics. The pre-pandemic period was from January 2017 to January 2020, and the post-pandemic period was from February 2020 to December 2020.ResultsA declining trend in antibiotic consumption was observed immediately following the COVID-19 pandemic (β2 = −4.099; p &lt; 0.001). Regarding the route of administration, a larger decrease in the consumption of oral antibiotics was observed compared to parenteral (β2 = −3.056; p &lt; 0.001). The decrease in antibiotic consumption in the Watch category (β2 = −2.164; p &lt; 0.001) was larger than in the Access category (β2 = −1.773; p &lt; 0.001), and penicillins (J01C) (β2 = −1.261; p &lt; 0.001) showed a higher decline than cephalosporins (J01D) (β2 = −1.147; p &lt; 0.001). An increasing trend of broad-spectrum antibiotic consumption was observed after the onset of the pandemic (β3 = 0.021; p = 0.015). Expenditures on and consumption of antibiotics follow essentially the same trend.ConclusionDespite an initial decline in antibiotic consumption at the start of the COVID-19 pandemic, it had returned to prior levels by the end of 2020. Findings underscore the continued importance of antibiotic stewardship initiatives.
Adapting a sexual and reproductive health program for Latina teens and their female caregivers: a qualitative study
Authors: Merrill Katherine G. , Fuentes Jacqueline , Merrill Jamison , DeCelles Jeff , Silva Jacqueline , Sedeño Angela , Salgado Susana , Vargas Sara , Cano Jennifer K. , Nabor Veronica , Rodriguez Laura , Melgoza Vanessa , Mora Corin , Baumann Ana A. , Guastaferro Kate , Donenberg Geri R. 
Published: February 2025

BackgroundAdaptation is widely recognized as important when interventions are to be delivered in new settings or with new populations. However, there are gaps in the literature on how adaptations are carried out and documented. IMARA is a 12-h evidence-based sexual health intervention for Black teens and their mothers, designed for delivery over two days. We present our systematic process of adapting IMARA for Latinas to produce the Floreciendo (“Blooming”) program for Latina teens (14–18 years old) and their female caregivers (e.g., mothers, sisters).MethodsUsing a community-based participatory research (CBPR) approach, we carried out a qualitative study that included 7 focus groups: 4 with staff from community partner organizations (n = 29), 2 with Latina teens (14–18 years) (n = 11), and 1 with female caregivers (n = 5). We also conducted seven key informant interviews with experts in sexual health and Latina health. We used Escoffery’s recommended steps to guide our adaptation process. Data were thematically coded and adaptations documented using the FRAME for reporting modifications to evidence-based interventions.ResultsInformed by the data, we grouped IMARA content into four sessions for Floreciendo, each with unique curricular content and designed to be delivered in two hours (eight hours total): (1) Foundations in Sexual Risk Prevention; (2) Condoms and Contraception; (3) Family Strengthening; and (4) Gender and Relationships. We documented adaptations made for each session. For example, participants emphasized unplanned pregnancy as an important issue facing Latina teens. In response, we added an activity providing hands-on experience with contraceptive methods. Participants also highlighted how gender norms and family expectations in Latine culture shape Latina teens’ sexual and reproductive health practices. We therefore developed activities and opportunities for discussion addressing these cultural influences. We removed IMARA activities considered of lower priority (e.g., portrayal of women in the media).ConclusionThis study addresses gaps in the literature by reporting in detail the adaptations we made to an evidence-based intervention using qualitative methods. The four curriculum sessions we generated through our adaptation process will form the basis of the intervention components we will test in future work using the multiphase optimization strategy (MOST) framework.
Sentinel-1 (S1) time series alignment method for rapeseed fields mapping
Authors: Maleki Saeideh , Baghdadi Nicolas , Najem Sami , Dantas Cassio Fraga , Ienco Dino , Bazzi Hassan 
Published: February 2025

IntroductionThis paper presents a comprehensive analysis of rapeseed fields mapping using Sentinel-1 (S1) time series data. We applied a time series alignment method to enhance the accuracy of rapeseed fields detection, even in scenarios where reference label data are limited or not available.MethodsTo this end, for five different study sites in France and North America, we first investigated the temporal transferability of the classifiers across several years within the same site, specifically using the Random Forest (RF) and InceptionTime algorithms. We then examined the spatiotemporal transferability of the classifiers when a classifier trained on one site and year was used to generate rapeseed fields map for another site and year. Next, we proposed an S1 time series alignment method to improve classification accuracy across sites and years by accounting for temporal shifts caused by differences in agricultural practices and climatic conditions between sites.Results and discussionThe main results demonstrated that rapeseed detection for 1 year, using training data from another year within the same site, achieved high accuracy, with F1 scores ranging from 85.5% to 97% for RF and from 88.2% to 98.3% for InceptionTime. When classifying using one-year training data from one site to classify another year in a different site, F1 scores varied between 48.8% and 97.7% for both RF and InceptionTime. Using a three year training dataset from one site to classify rapeseed fields in another site resulted in F1 scores ranging from 82.7% to 97.8% with RF and from 88.7% to 97.1% with InceptionTime. The proposed alignment method, designed to enhance classification using training and test data from different sites, improved F1 scores by up to 46.7%. These findings confirm the feasibility of mapping rapeseed with S1 images across various sites and years, highlighting its potential for both national and international agricultural monitoring initiatives.
Design, Synthesis, and Mechanistic Anticancer Evaluation of New Pyrimidine-Tethered Compounds
Authors: Reymova Farida , Sever Belgin , Topalan Edanur , Sevimli-Gur Canan , Can Mustafa , Tuyun Amaç Fatih , Başoğlu Faika , Ece Abdulilah , Otsuka Masami , Fujita Mikako , Demirci Hasan , Ciftci Halilibrahim 
Published: February 2025

Background: Despite recent breakthroughs in cancer treatment, non-small cell lung cancer (NSCLC) and breast cancer remain major causes of death from all malignancies. The epidermal growth factor receptor (EGFR) is an important mediator of the pathways involved in cell proliferation, apoptosis, and angiogenesis. Thus, its overexpression triggers several types of cancer, including NSCLC and breast cancer. Methods: In the current study, we synthesized new pyrimidine-tethered compounds (chalcone derivative (B-4), pyrazoline–carbothioamide (B-9), and pyrazoline–thiazole hybrids (BH1-7)). These compounds were then tested for cytotoxicity against A549 NSCLC and MCF-7 breast cancer cells. Results: Of these, B-4 displayed significant cytotoxicity against both cells (IC50 = 6.70 ± 1.02 µM for MCF-7; IC50 = 20.49 ± 2.7 µM for A549) compared to the standard agent lapatinib (IC50 = 9.71 ± 1.12 µM for MCF-7; IC50 = 18.21 ± 3.25 µM for A549). The anticancer potential of B-4 between Jurkat leukemic T cells and peripheral blood mononuclear cells (PBMCs) (healthy) was found to be selective. Mechanistically, 11.9% and 10.2% of A549 and MCF-7 cells treated with B-4, respectively, underwent apoptosis and B-4 produced 46% EGFR inhibition at a concentration of 10 μM. The B-4/EGFR complex obtained after induced fit docking was subjected to 300 ns of molecular dynamics simulation, which confirmed the stability of the complex in a mimicked biological environment. On the other hand, B-4 was shown to have drug-like properties by in silico pharmacokinetic estimation. Conclusions: B-4 is an EGFR inhibitor and apoptosis inducer for future NSCLC and breast cancer studies.
Нерешенные вопросы стратификации сердечно-сосудистого риска: современное состояние проблемы
Authors: Суджаева О.А. 
Published: February 2025

В статье приведен обзор данных литературы, посвященной различным подходам к стратификации сердечно-сосудистого риска и риска развития неблагоприятных исходов. Проанализированы преимущества и ограничения наиболее часто употребляемых в разных географических регионах шкал. Наиболее часто используются модификации шкалы Европейского общества кардиологов SCORE, Британского кардиологического сообщества QRISK, шкала риска Фрамингема (FRS) и ее модификации – для ишемической болезни сердца (FRS-CHD) и для сердечно-сосудистых заболеваний (FRS-CVD), калькулятор риска Объединенного британского общества (JBS), шкала Американской коллегии кардиологов / Американской ассоциации сердца (ACC/AHA) для атеросклеротических сердечно-сосудистых заболеваний и таблицы риска Всемирной организации здравоохранения (WHO). Установлено, что указанные инструменты обладают различной диагностической ценностью в разных регионах и у лиц разного пола. Также выявлено, что сопутствующие (коморбидные) заболевания и состояния могут существенно модифицировать вычисленный с помощью вышеуказанных инструментов сердечно-сосудистый риск, что диктует необходимость дальнейших исследований по разработке диагностических шкал, адаптированных к географическому региону, и установлению информативности модификаторов риска у разных категорий пациентов.
The article provides a review of literature data covering various approaches to stratification of cardiovascular risk and the risk of adverse outcomes. Advantages and limitations of the scales most commonly used in different geographical regions are analyzed. The most commonly used modifications are the scale of the European Society of Cardiology SCORE, the British Cardiological Community QRISK, the Framingham risk scale and its modifications for coronary heart disease (FRS-CHD) and for cardiovascular diseases (FRS- CVD), the risk calculator of the United British Society (JBS), the scale of the American College of Cardiology / The American Heart Association (ACC/AHA) for Atherosclerotic Cardiovascular Diseases, and the World Health Organization risk tables. It was established that these tools had different diagnostic value in different regions and in individuals of different genders. It was also revealed that concomitant (comorbid) diseases and conditions could significantly modify the cardiovascular risk calculated using the above tools, thus necessitating further research to elaborate diagnostic scales adapted to specific geographical regions and to establish the informativeness of risk modifiers in different patients’ categories.
ANALISIS KINERJA KEUANGAN SEBELUM DAN SELAMA PANDEMI COVID-19 PADA PERUSAHAAN TELEKOMUNIKASI YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Amelia Mita , Kusuma Indra Cahya , Aziz Ayi Jamaludin 
Published: February 2025

Abstract: Financial peirformancei is a picturei of a company's financial condition in a ceirtain peiriod. This study aims to deiteirminei thei financial peirformancei of teileicommunications companieis listeid on thei Indoneisia Stock EIxchangei beiforei and during thei Covid-19 pandeimic for thei 2019-2021 peiriod. Thei samplei takein in this study was 4 companieis obtaineid through purposivei sampling teichniqueis. Thei meithod useid is quantitativei deiscriptivei, using financial ratios as a meiasurei of financial peirformancei. Thei reisults of this study show that financial peirformancei beiforei and during thei Covid-19 pandeimic in thei liquidity ratio for EIXCL, FREIN and TLKM companieis fluctuateid whilei ISAT deicreiaseid. Thei solveincy ratio for EIXCL, FREIN and ISAT companieis increiaseid whilei TLKM fluctuateid. Thei activity ratio for FREIN, ISAT and TLKM companieis fluctuateid whilei FREIN deicreiaseid. Thei profitability ratio for EIXCL, FREIN and TLKM companieis increiaseid whilei ISAT fluctuateid.

Keiywords: Covid-19 Pandeimic, Financial Peirformancei, Financial Ratio
ANALISIS PERLAKUAN AKUNTANSI PRODUK RUSAK DALAM PENENTUAN HARGA POKOK PRODUKSI PT. MILKO BEVERAGE INDUSTRY
Authors: Nasution Masita Amalia , Afif M.Nur , Kusuma Indra Cahya 
Published: February 2025

Abstrak: Harga Pokok Produksi adalah biaya yang telah terjadi untuk mendapatkan barang atau jasa.Sering di sebut sebagai biaya produksi. Harga jual perusahaan harus dapat menutupi biaya produksi yang dikeluarkan dan mendapatkan keuntungan bagi perusahaan. Penelitian ini bertujuan untuk mengetahui perhitungan harga pokok produk rusak dan perlakukan akuntansi produk rusak pada PT Milko Beverage Industry. Mekanismie yang pakai pada studi penelina ini yaitu metode deskriptif kuantitatif. metode pengumpulan data menggunakan studi Pustaka da studi lapangan hasil penelitian yang telah dilakukan menunjukkan bahwa dalam melaksanakan prosedur perhitungan harga pokok dan perlakuan produk rusak secara belum sepenuhnya sesuai teori.

Keywords: Harga Pokok Produksi, Perlakukan Akuntansi
PENENTUAN HARGA JUAL KAMAR MELALUI IMPLEMENTASI ACTIVITY BASED COSTING SYSTEM PADA HOTEL NEW AYUDA 2
Authors: Lestari Destiana Puji , Afif M. Nur , Triwidatin Yuppy 
Published: February 2025

Activity Based Costing is a method that can reduce cost distortions because it is caused by traditional cost accounting calculations. The calculation of the selling price of rooms at the New Ayuda 2 Hotel still uses traditional methods. The research is aimed at knowing how the difference in the calculation of selling prices between the Traditional method and the ABC Method. The data analysis method used in this study is a qualitative descriptive analysis with the calculation of the basic formula for determining the cost of goods using the Activity Based Costing method. The results of this study show that the calculations used at the New Ayuda 2 Hotel are still overcosting and undercosting when compared to the ABC system, because calculations using traditional methods only use one cost driver so that there are many cost distortions and result in irrelevant selling price calculations. Companies should reevaluate the cost-charging system in determining the selling price of rooms.

Keywords: ABC Method, Traditional Method, Selling Price
Gambaran Pemilihan Bahan dan Higienitas Pengolahan Makanan Balita di Posyandu Wonotingal Kecamatan Candisari Semarang
Authors: Devi Chindya Paramitha , Untari  
Published: February 2025

Nutritional problems in Indonesia occur due to various factors, such as food intake, environment including hygiene and sanitation, socio-economic, family characteristics, and the presence of infection. Children who have poor nutritional status are susceptible to infection, because children were lack of immunity. Conversely, children who suffer from infections do not have sufficient appetite, resulting in children being malnourished and falling into poor nutritional status. So, infection and nutritional status were correlated. Malnutrition in children is influenced by the level of knowledge, attitudes and behavior of mothers in choosing the right food ingredients. The practice of selecting ingredients and hygiene of food processing is closely related to the emergence of certain diseases or infections, so further research is needed. This descriptive study focused on the description of the selection of ingredients and processing of toddler food by mothers, which wass carried out using a research instrument in the form of a questionnaire. The results of the study of 20 respondents (mothers of toddlers) conducted at the Posyandu of Wonotingal Village regarding the practice of mothers in preparing food for children (toddlers) were classified as "Defficient" in terms of the aspect of selecting ingredients and hygiene aspects of food processing, namely with indicators of selecting types of spices and toddler snacks, as well as the implementation of Clean and Healthy Living Behavior.

ABSTRAK
Masalah gizi di Indonesia terjadi karena beragam faktor, seperti asupan makanan, lingkungan termasuk higiene dan sanitasi, sosial ekonomi, karakteristik keluarga, adanya infeksi. Anak yang mempunyai status gizi kurang mudah terkena infeksi, karena anak tidak mempunyai daya tahan tubuh yang cukup. Sebaliknya, anak yang menderita infeksi tidak mempunyai nafsu makan yang cukup, akibatnya anak kekurangan gizi dan jatuh pada status gizi kurang, sehingga keterkaitan infeksi dengan status gizi mempunyai hubungan timbal balik yang kuat. Kurangnya gizi pada anak dipengaruhi oleh tingkat pengetahuan, sikap dan perilaku ibu dalam memilih bahan makanan yang benar. Praktik pemilihan bahan dan higienitas pengolahan bahan pangan erat kaitannya dengan munculnya penyakit atau infeksi tertentu, sehingga dibutuhkan penelitian lebih lanjut. Penelitian deskriptif ini berfokus pada gambaran pemilihan bahan dan pengolahan bahan makanan balita oleh Ibu, yang dilakukan dengan instrumen penelitian berupa kuisioner. Hasil penelitian terhadap sejumlah 20 responden (ibu balita) yang dilaksanakan di Posyandu Kelurahan Wonotingal terkait praktik ibu dalam penyiapan makanan anak (balita) tergolong “Kurang Baik” ditinjau dari aspek pemilihan bahan dan aspek higienitas pengolahan pangan, yaitu dengan indikator pemilihan jenis bumbu dan makanan selingan balita, serta penerapan Perilaku Hidup Bersih dan Sehat (PHBS).