bluuebunny/crossref_metadata_2025_split huggingface dataset:
InP/ZnSeS/ZnS Core–Shell Quantum Dots as Novel Saturable Absorbers in Mode‐Locked Fiber Lasers
Authors: Lou Yajun , He Pengfei , Ge Boyuan , Duan Xijian , Hu Lei , Zhang Xiaoli , Tao Lili , Zhang Xinhai 
Published: December 2022

AbstractIn this study, red light emitting InP/ZnSeS/ZnS quantum dots (QDs) are prepared by thermal injection method. The results show that the InP/ZnSeS/ZnS QDs saturable absorbers (SA) have good nonlinear saturable absorption properties with modulation depth of 24.2% and saturation intensity of 0.08 KW cm−2. Then the QD SAs are applied to the erbium‐doped fiber laser (EDFL) ring cavity system, and a mode‐locked laser pulse with a pulse width of 635 fs is generated. In addition, the pulse width is determined by the carrier recovery time, which is closely related to the defect density in the material. A large number of defects are eliminated in the QDs by hydrogen fluoride (HF) treatment, and the pulse width is reduced from 635 to 450 fs. Results of time‐resolved photoluminescence and ultrafast transient absorption spectroscopy (TAS) show that HF treatment indeed reduces defects in InP/ZnSeS/ZnS QDs, indicated by the decrease of the carrier recovery time. This is different from the reported 2D SA materials, which usually reduce the carrier recovery time by increasing the defect density. This study will inspire new applications of QDs in ultrafast photonics and nonlinear optics.
Van der Waals Interlayer Coupling Induces Distinct Linear Dichroism in WSe2 Photodetectors
Authors: Wei Zhenhua , Zheng Xiaoming , Wei Yuehua , Zhang Xiangzhe , Luo Wei , Liu Jinxin , Peng Gang , Huang Han , Lv Tieyu , Zhang Xueao , Deng Chuyun 
Published: December 2022

AbstractDriven by the unique linear dichroism feature of anisotropic two‐dimensional (2D) materials, much attempt has been made to introduce artificial anisotropy into isotropic 2D materials to deliver polarization‐sensitive performance. However, those methods have not been widely promoted because of technical limitations. This paper reports on the successful modulation to the structural symmetry of WSe2 through van der Waals (vdW) interlayer coupling. Correspondingly, both the polarized Raman and photoluminescence (PL) spectra of WSe2 in heterostructure exhibit periodic variation tendency. Similarly, direction‐sensitive electronic transport has also been observed in WSe2/CrOCl heterostructure, and the conductance along armchair direction is ≈1.5 times of that along zigzag direction. As a functional illustration to the interlayer coupling induced linear dichroism, angle‐dependent photodetection is conducted to WSe2/CrOCl device. With light irradiation at 532 nm, the device photocurrent along armchair direction is 1.27 times higher than that along zigzag direction. The abnormal linear dichroism of WSe2 in the study clearly proves that few‐layer WSe2 on CrOCl flake has been entitled with artificial anisotropy. The interlayer coupling method is feasible and practical in 2D‐material range, offering the possibility to develop polarization‐dependent electronic, pyroelectric, and photoelectric devices from isotropic 2D materials.
Plant‐Wearable Sensors for Intelligent Forestry Monitoring
Authors: Li Yifei , Xu Haoyan , Han Chuanlong , Bai Yuan , Wang Yuliang , Yu Haipeng , Song Wenlong , Sun Zhuangzhi 
Published: December 2022

AbstractFlexible plant‐wearable sensors show great potential for precise and intelligent monitoring of real‐time physical and chemical signals in forestry seedlings to optimize their growth environment, increase carbon sequestration, and promote underforest ecosystems. Furthermore, plant‐wearable sensors can help prevent threats such as forest ecological deterioration, forest diseases, and insect pests. Herein, recent advances in emerging plant‐wearable sensors used in forestry for applications including the monitoring of plant physiological metabolism and plant growth in seedling cultivation, early warning of forest pest and disease, prevention and warning of forest fire, and growing environment monitoring of trees are reviewed. Typical sensing technologies, designs, structural compositions, and sensing principles of emerging plant wearables are highlighted. Current technical bottlenecks of wireless growth monitoring system and self‐powered energy supply strategies are also discussed in terms of their practical application. Finally, the research directions and challenges of flexible plant wearables in intelligent forestry monitoring are explored in detail.
Multi‐sensor data fusion for swine house environment evaluation and control
Authors: Chen Chong , Shen Cuifeng 
Published: December 2022

AbstractData fusion from various sensors can obtain more accurate and reliable results than a single monitoring sensor. The data of air quality in the swine breeding environment comes from various sensors; therefore, the data must be fused. In this study, statistical criteria, batch estimation theory, a fuzzy comprehensive evaluation (FCE) method, as well as an improved analytic hierarchy process (IAHP), were combined to provide accurate data for multi‐sensor data fusion modeling. To make a fair comparison, four statistical criteria were employed to process abnormal data gross errors. Besides, an improved batch estimation adaptive weighted fusion method was adopted to, respectively, integrate the data from temperature, humidity, and concentrations of ammonia (NH3), carbon dioxide (CO2), and hydrogen sulfide (H2S) of air quality at the data level. The predetermined weights were given using IAHP combined with the knowledge of experts. To decide the fuzzy membership values of each environmental parameter, we presented a method to establish fuzzy membership functions and devised a calculation method for related parameters. The gaussmf type membership function was employed to build a global fusion model that fits well with IAHP–FCE. The IAHP–FCE method was exploited to comprehensively integrate multi‐sensor data at the decision level. Experimental results show that the presented method can improve the data accuracy and provide decision results and scientific basis for the precision control of swine breeding environment.
Visualization of enantioselective recognition and separation of chiral acids by aggregation‐induced emission chiral diamine
Authors: Qi Chunxuan , Wei Keyue , Li Qingyang , Li Yuemei , Su Xiaolong , Yang Jun‐Cheng , Tian Jingjing , Chen Pu , Feng Hai‐Tao , Tang Ben Zhong 
Published: December 2022

AbstractEnantioselective recognition and separation are the most important issues in the fields of chemistry, pharmacy, agrochemical, and food science. Here, we developed two optically active diamines showing aggregation‐induced emission (AIE) that can discriminate 5 kinds of chiral acids with high enantioselectivity. Especially, a very high fluorescence intensity ratio (Il/Id) of 281 for (±)‐Dibenzoyl‐d/l‐tartaric acid was obtained through the collection of fluorescence change after interaction with chiral AIE‐active diamine. By virtue of AIE property and intermolecular acid‐base interaction, enantioselective separation was facilely realized by simple filtration of the precipitates formed by chiral AIE luminogen (AIEgen) and one enantiomer in the racemic solution. The chiral HPLC data indicated that the precipitates of AIEgen/chiral acid possessed 82% l‐analyte (the enantiomeric excess value was assessed to be 64% ee). Therefore, this method can serve as a simple, convenient, and low‐cost tool for chiral detection and separation.
The predictive equations of resting metabolic rate for Tibetan adolescents aged 13–18 in Tibet, China
Authors: Sun Yi , Liu Yuan , Yin Xiaojian , Li Ming , Zhang Ting , Zhang Feng , Guo Yaru , Sun Pengwei 
Published: December 2022

AbstractObjectivesThe resting metabolic rate (RMR) predictive equations suitable for Tibetan adolescents in Tibet, China, were developed to provide a reference for their reasonable energy intake.MethodsWe measured RMR by indirect calorimetry and body composition by bioelectrical impedance analysis in 325 Tibetan adolescents aged 13–18 years in Tibet, China. Stepwise regression analysis was used to develop the predictive equations. Pearson correlation analysis, paired sample t test, bias rate, concordance correlation coefficient (CCC) and Bland–Altman were used to verify the validity of the predictive equations.ResultsThe R2 of Model 8 (0.642) was larger than Model 2 (boys, 0.642; girls, 0.533) and Model 7 (0.540), and Model 10 (0.534) was larger than Model 4 (boys, 0.531; girls, 0.443) and Model 9 (0.477).Compared with the existing predictive equations, the correlation (0.68–0.84) between the predicted values and the measured values, CCC (0.74–0.81) and consistency (Similar proportions within the upper and lower limits but lower differences) were higher and the bias rate (−1.0% to −2.5%) and root mean square error (207.4–263.7 kcal/day) were lower in this study. By comprehensive comparison, Model 8 and Model 10 were more valid.ConclusionsThe existing predictive equations cannot accurately predict the RMR of Tibetan adolescents in Tibet, China. In this study, the age segmentation predictive equations with age, sex, and fat free mass (FFM) as independent variables were more valid. The predictive equations were as follows: RMR (kcal/day) = 50.1 × FFM (kg) − 202.8 × Sex (F: 0; M: 1) − 72.1 × Age + 930.3, 13–15 years; RMR (kcal/day) = 58.4 × FFM (kg) − 441.1 × Sex (F: 0; M: 1) − 702.2, 16–18 years.
Pure total flavonoids from citrus improve nonalcoholic steatohepatitis liver inflammatory responses by regulating the CCL2/CCR2‐PI3K‐Akt signal transduction pathway
Authors: Wu Liyan , Lu Zengsheng , He Beihui , Yu Jianshun , Yan Maoxiang , Jiang Jianping , Chen Zhiyun 
Published: December 2022

AbstractBackground and AimNonalcoholic steatohepatitis (NASH) is a critical stage in the prognosis of nonalcoholic fatty liver disease (NAFLD). Pure total flavonoids from circus (PTFC) play essential roles in the improvement of NASH symptoms, but the underlying regulatory mechanism remains elusive. Our previous high‐throughput omics screening results indicate that the CCL2/CCR2‐PI3K‐Akt signaling pathway is a key pathway that regulates the liver inflammatory response. PTFC may regulate the CCL2/CCR2‐PI3K‐Akt signaling pathway to improve the liver inflammatory response.MethodsA mice model of NASH was established by a high‐fat diet, and PTFC was used as treatment. Hematoxylin‐eosin and oil red O staining were used to observe the pathological changes in the liver tissue. Western blotting and real‐time PCR were used to measure the mRNA and protein levels in the liver. The expression of proinflammatory cytokines in the peripheral blood and liver tissues was measured by liquid suspension array. An automatic biochemical method was used to examine serum transaminases and lipids levels, as well as liver lipids.ResultsCompared with the mice in the high‐fat diet group, mice in the HFD + PTFC group showed significantly improved liver histopathology, and levels of serum transaminase and lipids, liver lipids and serum proinflammatory cytokines. Moreover, the mRNA and protein expression and phosphorylation levels of key signaling molecules in the CCL2/CCR2‐PI3K‐Akt signal transduction pathway were obviously reduced by PTFC treatment.Conclusive RemarksPTFC can ameliorate NASH symptoms, and the mechanism may be related to regulating the CCL2/CCR2‐PI3K‐Akt signal transduction pathway to reduce the liver inflammatory response.
Synthesis and antitumoral evaluation of natural product‐like compounds based on tropolone and benzotropolone derivatives
Authors: Eugui Macarena , Lucero Valeria , do Carmo Hugo , Cabrera Mauricio , Moyna Guillermo 
Published: December 2022

AbstractWe present the preparation of a series of novel natural product‐like homobarrelenones, norcaranes, and dihydrofluorenones through a diversity‐oriented synthetic (DOS) strategy that combines Diels–Alder reactions and phototransformations, as well as their biological evaluation against MCF‐7, HT‐29, and NCI‐H460 human tumor cells. Six of these demonstrated activities in the micromolar range against the three cell lines, and none were predicted as cytotoxic against human nontumor cells according to in silico studies. In addition, within the set of active derivatives, three exhibited low unspecific cytotoxicity in a sperm motility assay. The rich functionality of the new compounds makes them ideal candidates for exhaustive structure–activity relationship studies.
Synthesis of Picramide Using Nitration and Ammonolysis in Continuous Flow
Authors: Kumar Mittal Ankit , Prakash Gaurav , Pathak Pramod , Maiti Debabrata 
Published: December 2022

AbstractThis paper describes a safer, scalable and continuous process for synthesis of picramide. The process consists of two steps: step‐1. nitration of p‐nitroanisole (PNAN) to 2,4,6‐trinitrianisole (TNAN); step‐2. ammonolysis of TNAN to picramide. Both the steps were optimized in flow, with yield of 90% and 98% in step‐1 and step‐2 respectively. Picramide with HPLC purity greater than 99% was obtained. When compared with batch, in step‐1, flow process provided significant advantage in selectivity and yield. The optimized flow process was scaled to 25 g/hr production rate in a laboratory flow reactor. The method can be considered fit for the safe production of picramide at commercial scale.
Interchangeability and Disorder in the Solid‐State Structures of “Two Wall” Calix[4]pyrroles Equipped with Iodine and Ethynyl para‐Substituents
Authors: Rivoli Andrea , Gomila Rosa M. , Frontera Antonio , Ballester Pablo 
Published: December 2022

AbstractHerein, the synthesis and X‐ray structures of three α,β “two wall” aryl‐extended calix[4]pyrroles having either identical (symmetrically substituted) or different (non‐symmetrically substituted) meso‐aryl substituents (aryl=4‐ethynylphenyl and 4‐iodophenyl) are reported. The X‐ray structure of the co‐crystal formed by the two symmetrically substituted calix[4]pyrroles is also described. In the solid state, all studied α,β‐calix[4]pyrroles exhibit a 1,3‐alternate conformation with two co‐crystallized acetonitrile solvent molecules H‐bonded to adjacent cis‐pyrrole rings. Remarkably, the 1,3‐conformer of the non‐symmetrically substituted iodophenyl/ethynylphenyl compound is intrinsically chiral. The two enantiomers are present in the average asymmetric unit in a 65 : 35 occupancy ratio displaying a head‐to‐tail directional disorder. This is due to the functional complementarity and the isosteric and isoelectronic properties of the para‐substituents: iodo and ethynyl. That is, the negative belt of iodine is similar to the negative π‐system of the C≡C triple bond and the σ‐hole in the iodine atom is similar to the positive proton at the C≡C−H group.
Fear and promise of the unknown: How losses discourage and promote exploration
Authors: Chin Alycia , Hagmann David , Loewenstein George 
Published: December 2022

AbstractMany situations involving exploration, such as businesses expanding into new products or locations, expose the explorer to the potential for subjective losses. How does the potential to experience losses during the course of a search affect individuals' appetite for exploration? In three incentivized studies, we manipulate search outcomes by presenting participants either with a gain‐only environment or a gain‐loss environment. The two environments offer objectively identical incentives for exploration: Using a framing manipulation, we decrease gain‐loss payoffs and provide participants an initial endowment to offset the difference. Participants decide how to explore a one‐dimensional space, receiving payoffs based on their location each period. We predict and find that participants are motivated to avoid losses, which increases exploration when they are incurring losses but decreases exploration when they face the potential for losses. We conclude that exploration is driven by hope of potential gains, constrained by fear of potential losses, and motivated by avoidance of experienced losses.
Retrospective, real‐life study of venetoclax plus azacitidine or low‐dose cytarabine in French patients with acute myeloid leukemia ineligible for intensive chemotherapy
Authors: Laloi Louise , Billotey Natacha Chaumard , Dumas Pierre‐Yves , Paul Franciane , Villate Alban , Simand Célestine , Fornecker Luc , Puisset Florent , Bertoli Sarah , Simonet Marion Boissard , Laribi Kamel , Houyou Dyhia , Santagostino Alberto , Michel Claire , Guepin Gabrielle Roth , Guerineau Elodie , Tabrizi Reza , Hunault Mathilde , Giltat Aurélien , Kaphan Eléonore , Bulabois Claude , Cartet Elodie , Rocher Clément , Lachenal Florence , Morisset Stéphane , Récher Christian , Pigneux Arnaud , Belhabri Amine , Michallet Mauricette , Michallet Anne‐Sophie 
Published: December 2022

AbstractBackgroundRecently, the combination of venetoclax plus a hypomethylating agent (HMA; azacitidine ordecitabine) or low‐dose cytarabine (LDAC) showed promise in Phase III trials in previously untreated AML. In France at the time of this study, venetoclax was not yet approved for AML and there were therefore no formal usage recommendations. Here we report the first study in a French cohort that assessed venetoclax in combination with existing treatments for AML under real‐life conditions.MethodThis retrospective, real‐life study collected data on venetoclax use and management in a French cohort with acute myeloid leukemia (AML) ineligible for intensive chemotherapy.ResultOf 118 patients, 81 were in second line/beyond (71.6% also hypomethylating agent [HMA]; 23.5% lowdose cytarabine [LDAC]) and 37 in first line. For venetoclax initiation, 57.3% underwent ramp up and 74.6% were hospitalized. Median venetoclax duration was 2.5 months (range 0.03‐16.2). With all treatment lines and regimens, most common grade 3/4 adverse events were hematologic (overall 96.4% of patients) and infections (57.1%). Dosage adjustments for drug interactions and safety varied between centers. In second‐line/beyond, median progression‐free survival was 4.0 months (95% confidence interval [CI] 2.7‐12.8) with venetoclax‐HMA and 3.4 months (1.3‐8.9) with venetoclax‐LDAC; overall response rate was 51.9% and 41.2%, respectively. Thus, we showed that venetoclax‐based treatment yields promising findings in patients with AML, but to address treatment complexity, practice harmonization is needed.
The Antinociceptive Effect of a Hydroalcoholic Extract of Polygala altomontana and Its Chemical Profile Using UPLC‐ESI‐QTOF‐HR‐MS
Authors: Pradi Lucas , Andrade Tassiane E. S. , Lacerda Jhuly W. F. , Karvat Jhenifer , Beppler Larissa M. , Tizziani Tiago , Santos Adair R. S. , Sandjo Louis P. 
Published: December 2022

AbstractThe hydroalcoholic extract of Polygala altomontana (30, 100, and 300 mg/kg, i.g.) showed a dose‐dependent antinociceptive action during the inflammatory phase of the formalin test. In addition, the preparation (30 and 300 mg/kg, i.g.) showed anti‐hyperalgesic action when tested on a mechanical nociception model. UPLC‐ESI‐QTOF‐MS data indicated the active extract contained phenylpropanoid sucrose esters, glycosylated quercetin derivatives, styrylpyrones, and coumarins. Some identified compounds, including styrylpyrones and coumarins, have previously demonstrated antinociceptive action. The results also show that P. altomontana shows potential for developing pain‐relieving herbal remedies and drugs.
Analyzing the Impact of Ramalina digitellata, R. fastigiata, R. fraxinea, and R. polymorpha's Usnic Acid Concentration on Antioxidant, DNA‐Protective, Antimicrobial, and Cytotoxic Properties
Authors: Kiliç Yayla Serpil , Kocakaya Zekiye , Karatoprak Gökçe Şeker , İlgün Selen , Ceylan Ahmet 
Published: December 2022

AbstractThe present study is focused on the antimicrobial, antioxidant, cytotoxic, and DNA protective effects of methanol extract obtained from R. digitellata, R. fastigiata, R. fraxinea, and R. polymorpha species that are distributed in Turkey. The highest total phenol content was determined in R. digitellata (144.6 mgGAE/gextract), and the highest total amount of flavonoids was found in R. fastigiata (20.40 mgGAE/gextract). The content of usnic acid was determined by High‐Performance Liquid Chromatography (HPLC) and the highest amount was found in R. digitellata. DPPH (1,1‐diphenyl‐2‐picrylhydrazyl) and ABTS [2,2’‐azinobis(3‐ethylbenzathiazoline‐6‐sulfonic acid)] radical scavenging methods were used for antioxidant activity. R. fraxinea showed the highest DPPH⋅ and ABTS+⋅ scavenging activity. In addition, the DNA protective effect was investigated using pBR322 plasmid DNA, and; all studied species were found to have DNA protective effects. The antibacterial activity was investigated using the disc diffusion method, and the R. digitellata methanol extract showed the best results with a 12.35 mm zone on Proteus mirabilis. On the human lung cancer (A549) and breast cancer (MDA‐MB‐231) cell lines, cytotoxic activity was assessed using an MTT assay. All lichen extracts were found to have a significant cytotoxic effect on both cancer cell lines at 1000 μg/mL concentration. These results suggest that Ramalina species may be potential candidates for developing new phytopharmaceuticals and functional components.
Spatio‐temporal metabolokinetics and therapeutic effect of CD106+ mesenchymal stem/stromal cells upon mice with acute lung injury
Authors: Zhang Leisheng , Zhuo Yi , Yu Hao 
Published: December 2022

AbstractLongitudinal investigations have revealed the unique attributes of mesenchymal stem/stromal cells (MSCs) in regenerative medicine. However, the spatio‐temporal metabolokinetics and efficacy of MSCs with vascular cell adhesion molecule 1 (also known as CD106) expression in phenotypes and therapeutic effect upon acute lung injury (ALI) mice are largely obscure. For the purpose, we took advantage of the “3IL”‐based strategy and Lentivirus‐mediated green fluorescent protein (GFP) delivery for the generation of the CD106+ subset (denote as CD106+‐MSCs) from umbilical cord‐derived MSCs (denote as NT‐MSCs). Therewith, the cellular phenotypes of CD106+‐MSCs including immunophenotypes, multilineage differentiation potential towards adipocytes and osteoblasts were confirmed by flow cytometry and qRT‐PCR assay. Meanwhile, multifaceted characteristics of transcriptomic features were analyzed by utilizing the RNA‐SEQ and bioinformatics. Furthermore, to compare the therapeutic effects and spatio‐temporal dynamics of CD106+‐MSCs, we conducted in vivo fluorescent tracer, hematoxylin and eosin staining, blood smear, blood routine and cytokine detection in mice. Herein, we generated CD106+‐MSCs with GFP expression and confirmed the conservative property of phenotypes. Compared to NT‐MSCs with minimal CD106 expression, CD106+‐MSCs manifested consistent distribution and metabolokinetics in vivo but with preferable ameliorative effect upon the pathological appearance and proinflammatory cytokine secretion in ALI mice. Collectively, our data indicated the preferable therapeutic effects of CD106+‐MSCs upon ALI mice, which would benefit the further exploration of the CD106+ subset for pulmonary diseases and investigational new drug application purposes.