bluuebunny/crossref_metadata_2025_split huggingface dataset:
The life and times of Pteridinium simplex
Authors: Darroch Simon A. F. , Gibson Brandt M. , Syversen Maggie , Rahman Imran A. , Racicot Rachel A. , Dunn Frances S. , Gutarra Susana , Schindler Eberhard , Wehrmann Achim , Laflamme Marc 
Published: May 2022

AbstractPteridinium simplex is an iconic erniettomorph taxon best known from late Ediacaran successions in South Australia, Russia, and Namibia. Despite nearly 100 years of study, there remain fundamental questions surrounding the paleobiology and paleoecology of this organism, including its life position relative to the sediment–water interface, and how it fed and functioned within benthic communities. Here, we combine a redescription of specimens housed at the Senckenberg Forschungsinstitut und Naturmuseum Frankfurt with field observations of fossiliferous surfaces, to constrain the life habit of Pteridinium and gain insights into the character of benthic ecosystems shortly before the beginning of the Cambrian. We present paleontological and sedimentological evidence suggesting that Pteridinium was semi-infaunal and lived gregariously in aggregated communities, preferentially adopting an orientation with the long axis perpendicular to the prevailing current direction. Using computational fluid dynamics simulations, we demonstrate that this life habit could plausibly have led to suspended food particles settling within the organism's central cavity. This supports interpretation of Pteridinium as a macroscopic suspension feeder that functioned similarly to the coeval erniettomorph Ernietta, emblematic of a broader paleoecological shift toward benthic suspension-feeding strategies over the course of the latest Ediacaran. Finally, we discuss how this new reconstruction of Pteridinium provides information concerning its potential relationships with extant animal groups and state a case for reconstructing Pteridinium as a colonial metazoan.
The Triumphs of Pelops and Bellerophon: Unique Mosaic Evidence ofRomanitasin Late Roman Britain
Authors: Beeson Anthony , Nichol Matt , Massey Richard 
Published: May 2022

AbstractA Roman villa building at Mud Hole, Boxford, West Berkshire, was examined by excavation in 2017 and 2019, and found to be of probable fourth-century date. One room of this otherwise seemingly modest villa contained a remarkable late fourth-century figured mosaic, which features a number of rare mythological subjects not previously encountered in Britain. Inscriptions suggest the name of the villa owner (Caepio) and his wife (Fortunata), with a possible Spanish connection. The mosaic's central panel is ornamented with the triumphs of Pelops and Bellerophon, the former known only from two other mosaics, in Syria and Spain. The borders also contain depictions of stories unknown on other mosaics, but all concerned with aspects of triumph. The central panel is upheld by walkingtelamones(giants), otherwise only known on a mosaic from Tusculum, and the mosaicists have attempted to use foreshortening to give the floor atrompe l'oeileffect. The rare subjects depicted on the floor all relate to either Poseidon, Pelops, Bellerophon or Atlas, and suggest high standards of mythological knowledge and longevity of classical culture amongst the villa-owning inhabitants of late fourth-century Berkshire. The mosaic shows a connection to earlier depictions of the Pelops story, but is highly original in its interpretation of them and follows a contemporary trend, not previously encountered in Britain, of its subjects breaking out from their ornamental borders. The mosaic is an altogether exceptional discovery and can be considered an important example of late Roman art so far found in Britain.
The lasting impact of war experiences on quality of life in long-lived retirement homes residents: The birth cohort 1906–1928
Authors: Perinić Lewis Ana , Škarić-Jurić Tatjana , Despot Lučanin Jasminka , Smolić Šime 
Published: May 2022

AbstractOnly a few studies have been conducted so far on the long-term impact of war. We investigated whether a life-long impact of the war experiences could be detected in advanced-agers who have successfully overcome all life's challenges. The participants in this study were oldest-old (80+ years) residents of retirement homes in Zagreb (Croatia), who were divided into two groups – ‘war-exposed’ and ‘not-exposed’ – according to their direct war experience (First World War, Second World War, Croatian Homeland War). Within this 1906–1928 birth cohort, a higher percentage of participants with war experiences reached extreme longevity (95+ years). We found no significant difference (p< 0.01) between the two groups concerning demographic and socio-economic characteristics, their life satisfaction, their self-rated current health and functional ability status. Despite numerous similarities, several traits related to life-history, current quality of life, attitudes and reflections distinguish the group of participants with direct war experience. The kind of war involvement – active military service, imprisonment in concentration camps or prisons, forced migration due to war and war-related death of close family members – stretched through various aspects of the life-history features, quality of life and attitudes. It differed for men and women, so it is no wonder that the significance pattern in the two genders mostly seems mutually exclusive. Socio-economic situations strongly differed by gender and according to the kind of war exposure, amplifying the differences within the ‘war-exposed’ group in terms of the life-long impact of wars on their lives. Therefore, we could claim that the war experiences were not the same for everybody, and that they had lasting consequences on the lifecourse of persons who directly faced war-related events. The results also point to the high resilience capacity as a common feature among persons who survived direct exposure to at least two wars and yet survived to exceptionally old age.
Efficient representation of piecewise linear functions into Łukasiewicz logic modulo satisfiability
Authors: Preto Sandro , Finger Marcelo 
Published: May 2022

AbstractThis work concerns the representation of a class of continuous functions into Logic, so that one may automatically reason about properties of these functions using logical tools. Rational McNaughton functions may be implicitly represented by logical formulas in Łukasiewicz Infinitely-valued Logic by constraining the set of allowed valuations; such a restriction contemplates only those valuations that satisfy specific formulas. This work investigates two approaches to such depiction, called representation modulo satisfiability. Furthermore, a polynomial-time algorithm that builds this representation is presented, producing a pair of formulas consisting of the representative formula and the constraining one, given as input a rational McNaughton function in a suitable encoding. An implementation of the algorithm is discussed.
Stonehouse: Scotland's last new town, c. 1967–1977
Authors: Fair Alistair 
Published: May 2022

AbstractThis article examines the proposals for Stonehouse, designated as the sixth Scottish new town in 1972 but abandoned in 1976. Several themes emerge, with lessons for the wider urban and political histories of 1970s Britain. First, the evolving plans demonstrate the ‘malleability’ of the post-war ‘new town idea’, conceptually and organizationally. Second, cancellation was the consequence of short-term factors, changing strategic objectives and local government reform, rather than being the result of a sudden ideological pivot towards inner-city renewal. Third, Stonehouse counters established narratives of the practice and decline of regional planning in post-war Britain. At least in a Scottish context, regional planning took on new forms during the mid-1970s.
Fifty Years of Prolog and Beyond
Authors: KÖRNER PHILIPP , LEUSCHEL MICHAEL , BARBOSA JOÃO , COSTA VÍTOR SANTOS , DAHL VERÓNICA , HERMENEGILDO MANUEL V. , MORALES JOSE F. , WIELEMAKER JAN , DIAZ DANIEL , ABREU SALVADOR , CIATTO GIOVANNI 
Published: May 2022

AbstractBoth logic programming in general and Prolog in particular have a long and fascinating history, intermingled with that of many disciplines they inherited from or catalyzed. A large body of research has been gathered over the last 50 years, supported by many Prolog implementations. Many implementations are still actively developed, while new ones keep appearing. Often, the features added by different systems were motivated by the interdisciplinary needs of programmers and implementors, yielding systems that, while sharing the “classic” core language, in particular, the main aspects of the ISO-Prolog standard, also depart from each other in other aspects. This obviously poses challenges for code portability. The field has also inspired many related, but quite different languages that have created their own communities. This article aims at integrating and applying the main lessons learned in the process of evolution of Prolog. It is structured into three major parts. First, we overview the evolution of Prolog systems and the community approximately up to the ISO standard, considering both the main historic developments and the motivations behind several Prolog implementations, as well as other logic programming languages influenced by Prolog. Then, we discuss the Prolog implementations that are most active after the appearance of the standard: their visions, goals, commonalities, and incompatibilities. Finally, we perform a SWOT analysis in order to better identify the potential of Prolog and propose future directions along with which Prolog might continue to add useful features, interfaces, libraries, and tools, while at the same time improving compatibility between implementations.
Better than expected: client and clinician experiences of videoconferencing therapy (VT) during the COVID-19 pandemic
Authors: Dowling Daniel , Martland Natasha , King Sophie , Nguyen Jen , Neely Elizabeth , Ball Jack , Grant Nina , Dom Gabriele , McNulty Nicholas 
Published: May 2022

Abstract
Videoconferencing therapy (VT) has been an emerging medium of psychological therapy, and during the COVID-19 pandemic there has been substantial growth in its usage as a result of home working. However, there is a paucity of research into client and clinician perceptions of VT. This study sought to assess client and staff experiences of VT. This mixed methods study produced both quantitative and qualitative data. Seven clients who had previously received VT and 11 psychotherapists who had previously delivered VT were recruited from two NHS sites. Clients and psychotherapists took part in qualitative interviews which were analysed using thematic analysis. Quantitative surveys were developed based on themes generated from the interviews and were completed by 172 clients and 117 psychotherapists. These were analysed using simple percentages. VT often exceeded client and psychotherapist expectations and overall experiences of VT were generally positive, although there were mixed findings regarding the therapeutic alliance. Several barriers to VT were cited, such as IT issues, and challenges identified in conducting behavioural experiments, and potential exclusion of certain populations were also cited. The medium of VT was received well by both clients and clinicians, with advantages around convenience seemingly outweighing losses in quality of therapeutic relationship. Future research should focus on overcoming barriers to accessing VT in populations prone to digital exclusion. NHS services not currently employing VT may wish to reconsider their stance, expanding choice of therapy delivery and improving accessibility.

Key learning aims

(1)
To gain insight into client and clinician experiences of VT during the COVID-19 pandemic.

(2)
To assess the acceptability and feasibility of VT within two NHS short-term psychological support services.

(3)
To identify barriers and facilitators to the implementation of VT within two NHS short-term psychological support services.
Boulder Detection in the Shallow Sub‐Seafloor by Diffraction Imaging With Beamforming on Ultra‐High Resolution Seismic Data—A Feasibility Study
Authors: Römer‐Stange N. , Wenau S. , Bihler V. , Keil H. , Ramos Córdova C. A. , Spiess V. 
Published: May 2022

AbstractSmall‐scale heterogeneities within the seafloor such as glacial boulders, concretions, or unexploded ordnance are of major scientific and economic interest. Because of their small size, such objects are hardly imageable by conventional seismic methods since they produce only faint diffractions. Despite the growing interest, reliable and efficient object detection methods are still not established. So, a marine acquisition system to image objects in the size range 0.3–4.1 m in the near‐surface has been designed and workflows have been developed. Source signals with a central frequency of ∼1,000 Hz are necessary to generate diffractions for the object size range. Performing beam pattern analyses, a rigid tow frame with the dimensions 8 × 3 m and attached hydrophones was designed. A synthetic aperture approach is realized to improve the resolution. Reflection events are suppressed in Normal‐Move‐Out corrected shot gathers by the muting of high singular values to enhance the diffractions. The diffractions are imaged with a beamforming algorithm with a high efficiency, as a total swath angle of about 80° in across‐track direction is covered. The processing of synthetic data sets allows an optimization and validation of the workflow and sensitivity analyses. Ground truthing is achieved with 1–2 m large boulders on the seafloor in 22 m depth, which were identified in a Multi‐Beam Echo Sounder data set. Although diffractions are only weak events in seismic data sets, 3D object detection with seismic beamforming has been found to be an efficient and reliable method to perform derisking for offshore infrastructure installations, drillings, or geologic interpretation.
Large‐Eddy Simulations of a Convection Cloud Chamber: Sensitivity to Bin Microphysics and Advection
Authors: Yang Fan , Ovchinnikov Mikhail , Thomas Subin , Khain Alexander , McGraw Robert , Shaw Raymond A. , Vogelmann Andrew M. 
Published: May 2022

AbstractBin microphysics schemes are useful tools for cloud simulations and are often considered to provide a benchmark for model intercomparison. However, they may experience issues with numerical diffusion, which are not well quantified, and the transport of hydrometeors depends on the choice of advection scheme, which can also change cloud simulation results. Here, an atmospheric large‐eddy simulation model is adapted to simulate a statistically steady‐state cloud in a convection cloud chamber under well‐constrained conditions. Two bin microphysics schemes, a spectral bin method and the method of moments, as well as several advection methods for the transport of the microphysical variables are employed for model intercomparison. Results show that different combinations of microphysics and advection schemes can lead to considerable differences in simulated cloud properties, such as cloud droplet number concentration. We find that simulations using the advection scheme that suffers more from numerical diffusion tends to have a smaller droplet number concentration and liquid water content, while simulation with the microphysics scheme that suffers more from numerical diffusion tends to have a broader size distribution and thus larger mean droplet sizes. Sensitivities of simulations to bin resolution, spatial resolution, and temporal resolution are also tested. We find that refining the microphysical bin resolution leads to a broader cloud droplet size distribution due to the advection of hydrometeors. Our results provide insight for using different advection and microphysics schemes in cloud chamber simulations, which might also help understand the uncertainties of the schemes used in atmospheric cloud simulations.
A Methodology for Studying the Hydroelastic Response of Submerged Flexible Vegetation
Authors: Gundersen D. G. , Christensen K. T. , Blois G. 
Published: May 2022

AbstractMost fluvial vegetation canopies embody some degree of structural flexibility, resulting in hydroelastic phenomena linking plant deformation and fluid flow. Quantification of such coupled fluid‐structure motion is critical in investigating key fluvial processes. The present work presents an experimental protocol that enables such quantification. High‐speed particle image velocimetry data of unidirectional flow surrounding idealized, submerged canopy elements, consisting of polyurethane rubber models, together with the corresponding solid displacement field, were simultaneously obtained by combining fluorescent imaging and refractive index matching. The operating principle of the approach employed herein involves seeding the two phases with different tracers, facilitating independent interrogation of the dynamics of each. Time‐resolved data allowed for observation of the dynamic link between a deformable object and the surrounding flow field.
METTL3-mediated m6A RNA methylation regulates dorsal lingual epithelium homeostasis
Authors: Xiong Qiuchan , Liu Caojie , Zheng Xin , Zhou Xinyi , Lei Kexin , Zhang Xiaohan , Wang Qian , Lin Weimin , Tong Ruizhan , Xu Ruoshi , Yuan Quan 
Published: May 2022

AbstractThe dorsal lingual epithelium, which is composed of taste buds and keratinocytes differentiated from K14+ basal cells, discriminates taste compounds and maintains the epithelial barrier. N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotic cells. How METTL3-mediated m6A modification regulates K14+ basal cell fate during dorsal lingual epithelium formation and regeneration remains unclear. Here we show knockout of Mettl3 in K14+ cells reduced the taste buds and enhanced keratinocytes. Deletion of Mettl3 led to increased basal cell proliferation and decreased cell division in taste buds. Conditional Mettl3 knock-in mice showed little impact on taste buds or keratinization, but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation recovery. Mechanically, we revealed that the most frequent m6A modifications were enriched in Hippo and Wnt signaling, and specific peaks were observed near the stop codons of Lats1 and FZD7. Our study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation.
Mental disorders following COVID-19 and other epidemics: a systematic review and meta-analysis
Authors: Leung Candi M. C. , Ho Margaret K. , Bharwani Alina A. , Cogo-Moreira Hugo , Wang Yishan , Chow Mathew S. C. , Fan Xiaoyan , Galea Sandro , Leung Gabriel M. , Ni Michael Y. 
Published: May 2022

AbstractCOVID-19 has imposed a very substantial direct threat to the physical health of those infected, although the corollary impact on mental health may be even more burdensome. Here we focus on assessing the mental health impact of COVID-19 and of other epidemics in the community. We searched five electronic databases until December 9, 2020, for all peer-reviewed original studies reporting any prevalence or correlates of mental disorders in the general population following novel epidemics in English, Chinese or Portuguese. We synthesised prevalence estimates from probability samples during COVID-19 and past epidemics. The meta-analytical effect size was the prevalence of relevant outcomes, estimated via random-effects model.I2statistics, Doi plots and the LFK index were used to examine heterogeneity and publication bias. This study is pre-registered with PROSPERO, CRD42020179105. We identified 255 eligible studies from 50 countries on: COVID-19 (n = 247 studies), severe acute respiratory syndrome (SARS;n = 5), Ebola virus disease (n = 2), and 1918 influenza (n = 1). During COVID-19, we estimated the point prevalence for probable anxiety (20.7%, 95% CI 12.9–29.7), probable depression (18.1%, 13.0–23.9), and psychological distress (13.0%, 0–34.1). Correlates for poorer mental health include female sex, lower income, pre-existing medical conditions, perceived risk of infection, exhibiting COVID-19-like symptoms, social media use, financial stress, and loneliness. Public trust in authorities, availability of accurate information, adoption of preventive measures and social support were associated with less morbidity. The mental health consequences of COVID-19 and other epidemics could be comparable to major disasters and armed conflicts. The considerable heterogeneity in our analysis indicates that more random samples are needed. Health-care professionals should be vigilant of the psychological toll of epidemics, including among those who have not been infected.
Acetylation stabilizes stathmin1 and promotes its activity contributing to gallbladder cancer metastasis
Authors: Fan Kun , Ni Xiaojian , Shen Sheng , Gong Zijun , Wang Jiwen , Xin Yanlei , Zheng Bohao , Sun Wentao , Liu Han , Suo Tao , Ni Xiaoling , Liu Houbao 
Published: May 2022

AbstractGallbladder cancer is the most common biliary tract malignant tumor with highly metastatic characters and poor prognosis. However, the underlying mechanism remains unclear. Stathmin1 is ubiquitous phosphoprotein, regulating microtubule stabilization. We identified the acetylation of stahtmin1 at lysine 9 (K9) in gallbladder cancer. K9 acetylation of stathmin1 was reversely regulated by the acetyltransferase PCAF and the deacetylases sirt2. K9 acetylation of stathmin1 inhibited the combining of stathmin1 to E3 ubiquitin ligase RLIM, thereby inhibiting its ubiquitination degradation. Moreover, K9 acetylation also promoted the activity of stahtmin1 interacting and destabilizing microtubule through the inhibition of stathmin1 phosphorylation. K9 acetylated stathmin1 significantly promoted gallbladder cancer cell migration and invasion viability in vitro and lung metastasis in vivo, and indicated poor prognosis of nude mice. IHC assay suggested the positive correlation of high levels of K9 acetylation and stathmin1 expression in gallbladder cancer. Our study revealed that K9 acetylation up-regulated stathmin1 protein stability and microtubule-destabilizing activity to promoted gallbladder cancer metastasis, which provides a potential target for gallbladder cancer therapy.
Theory-guided design of hydrogen-bonded cobaltoporphyrin frameworks for highly selective electrochemical H2O2 production in acid
Authors: Zhao Xuan , Yin Qi , Mao Xinnan , Cheng Chen , Zhang Liang , Wang Lu , Liu Tian-Fu , Li Youyong , Li Yanguang 
Published: May 2022

AbstractThe pursuit of selective two-electron oxygen reduction reaction to H2O2 in acids is demanding and largely hampered by the lack of efficient non-precious-metal-based electrocatalysts. Metal macrocycles hold promise, but have been relatively underexplored. Efforts are called for to promote their inherent catalytic activities and/or increase the surface exposure of active sites. In this contribution, we perform the high-throughput computational screening of thirty-two different metalloporphyrins by comparing their adsorption free energies towards key reaction intermediates. Cobalt porphyrin is revealed to be the optimal candidate with a theoretical overpotential as small as 40 mV. Guided by the computational predictions, we prepare hydrogen-bonded cobaltoporphyrin frameworks in order to promote the solution accessibility of catalytically active sites for H2O2 production in acids. The product features an onset potential at ~0.68 V, H2O2 selectivity of >90%, turnover frequency of 10.9 s−1 at 0.55 V and stability of ~30 h, the combination of which clearly renders it stand out from existing competitors for this challenging reaction.