bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and influencing factors of corneal higher-order aberrations in patients with cataract
Authors: Zhou Suowang , Chen Xu , Ortega-Usobiaga Julio , Zheng Hansong , Luo Wenjing , Tu Biyue , Wang Yong 
Published: November 2022

Abstract
Purpose: To observe the distribution characteristics of corneal higher-order aberrations (HOAs) in cataract patients, and analyze the relationship of HOAs with patients' age and ocular biometric parameters.
Methods: This cross-sectional study review the patients undergoing cataract surgery in Wuhan Aier Eye Department from January to August 2022. Root mean square (RMS) of the total corneal HOA, spherical aberration (SA), coma and trefoil aberration for a corneal central region of 4mm and 6mm were measured by the Wavefront Aberrometer (OPD-Scan III; Nidek Inc, Tokyo, Japan). The biometric parameters were measured by swept source coherence laser interferometry (OA-2000; TOMEY Corp, Aichi, Japan). Subgroup analyses and multiple linear regression analyses were used to determine whether HOAs were associated with age and ocular biometric parameters.
Results: A total of 976 patients (976 eyes) were included, averagely aged 65 years. The mean RMS of total corneal HOA at central 4mm and 6mm optic zone were respectively 0.20μm and 0.65μm, the RMS of SA were 0.06μm and 0.30μm. Total HOA decreased with age until 60 years and then started to increase afterwards. Total HOA, coma and trefoil aberration increased with corneal astigmatism. Total HOA, SA, and coma aberration differ among different AL groups, and emmetropes had the smallest aberration.
Conclusions: With increasing age, the value of total HOA decrease first and started increasing at 60 years. The trends of corneal HOAs are consistent with corneal low-order aberrations. The values of total HOA, SA and coma aberration were the smallest in emmetropic eyes.
A Simple and Feasible Wall Pipe and Tank Thinning and Corrosion Detection Using Piezoceramic Transducers
Authors: Eftekhari Ali , Nejad Majid Baghaei , Abadi M. H. Shahrokh 
Published: November 2022

Abstract
Pipe wall thinning and leakage due to corrosion, caused by process restrictions or extensive usage, are significant safety concerns for pipes used in oil, petrochemical, and power plant industries. This paper introduces the feasibility of detecting pipelines and tank thinning damage using piezo-ceramic transducers resonating at 2MHz. Time and frequency processing was used in combination with the Empirical Mode Decomposition (EMD) as a signal processing method in different conditions. A steel box and pipe, as items under test, were used to imitate the real industrial tanks and pipes used in the petroleum industries. The box was exposed to sulfuric acid as a corrosive substance and parts of the steel pipe were shaved from the inside to simulate the corroded areas. The PZCs were installed on the right parts of the IUTs and thickness measurements were performed and compared with the results obtained from a standard commercial thickness gauge. The results show less than a 1% error in thickness compared with the standard equipment when a frequency domain is combined with EMD. Furthermore, the proposed system offers much more simplicity and cost-effectiveness than the standard one.
Facile fabrication of a novel self-healing and flame- retardant Hydrogel/MXene coating for wood
Authors: Zhao Xiaojiong , Tian Min , Wei Ruichao , Jiang Saihua H. 
Published: November 2022

Abstract
To improve flame retardancy of wood, a novel high-water-retention and self-healing polyvinyl alcohol/phytic acid/MXene hydrogel (M-hydrogel) coating was developed through facile one-pot heating and freeze-thaw cycle methods, and then painted on wood surface. The coating exhibit excellent self-healing property and significantly enhanced water-retention property (water content ≥90 wt%), due to the increased hydrogen bonds within the coating system with the presence of MXene nanosheets. Compared to pristine wood, the flame retardancy of coated wood is greatly improved, such as passed V0 rating in UL-94 test, increasing time to ignition (TTI, from 32 s to 69 s), and decreased heat release rate (HRR) and total release rate (THR) by 41.6% and 36.14%. The cooling effect and large thermal capacity of high-water-retention hydrogel, and physical barrier effects for flammable gas products, heat and oxygen by MXene nanosheets and the compact char layer formed during combustion play key roles in the flame retardancy enhancements of the wood. High thermal stability of MXene nanosheets is another beneficial factor. The detailed flame-retardant and self-healing mechanisms were proposed.
A combination interferometric and morphological image processing approach to rapid quality assessment of additively-manufactured cellular truss core components
Authors: Keene Lionel , Rogers Brian , Stobbe David , Lum Jordan , Tringe Joseph 
Published: November 2022

Abstract
Advanced manufacturing (AM) processes such as laser powder bed fusion (LPBF) are increasingly capable of fabricating components with useful and unprecedented mechanical properties by incorporating complex internal bracing structures. From the standpoint of quality control and assessment, however, internally complex assemblies present significant build-verification challenges. Here we propose a hybrid approach to inspection involving the application of computer-aided speckle interferometry (CASI) and morphological image processing as a rapid, inexpensive, and facile method for AM quality control. A simple optical system with variable sensitivity is shown to be effective for inspection of a titanium honeycomb component subjected to differential pressure. Results are compared to those achieved with computed tomography (CT), immersion ultrasound testing (UT), and optical holographic interferometry. Lastly, we propose several possible processing strategies for automated quality assessment based on this powerful hybrid approach.
Harmonization of dopamine transporter SPECT imaging improves segregation between patients with parkinson’s disease and healthy elderlies in multicentre cohort studies
Authors: Wakasugi Noritaka , Takano Harumasa , Abe Mitsunari , Sawamoto Nobukatsu , Murai Toshiya , Mizuno Toshiki , Matsuoka Teruyuki , Yamakuni Ryo , Yabe Hirooki , Matsuda Hiroshi , Hanakawa Takashi 
Published: November 2022

Abstract
Purpose
Dopamine transporter single-photon emission computed tomography (DAT-SPECT) is an indispensable method for investigating Parkinson’s disease (PD). However, it comprises several confounding factors for consideration in a multicentre study. We aimed to assess the impact of the harmonization of multisite data on the differentiation between patients with PD and healthy elderlies in this multicentre cohort study.
Methods
We acquired a specific binding ratio (SBR)s of DAT-SPECT in 72 healthy elderlies (HCs) and 81 patients with PD (PDs). We assessed the effects of the following correction method for SBR: age and sex correction, correction for scanner differences by phantom scanning (phantom correction), a standardized operation for SBR computation (operation standardization), and a data-driven statistical method. We investigated the changes in the SBR and area under the receiver operating characteristic curve (ROC-AUC) for PD diagnostic accuracy.
Results
Without correction, the SBR yielded fair discrimination of PDs and HCs (Hedge’s g = 2.82 and ROC-AUC = 0.926). Age-sex correction exerted a moderate effect (g = 2.76 and ROC-AUC = 0.936). Of the multisite harmonization methods, the combination of phantom and operation correction displayed the largest changes (g = 4.32, ROC-AUC = 0.992), followed by data-driven correction (g = 3.99, ROC-AUC = 0.987).
Conclusions
Our findings demonstrated the usefulness of the multisite harmonization of DAT-SPECT in a multicentre cohort. Prospective correction with phantom scanning and operation standardization was ideal for the robustness and interpretability of the corrected values. The data-driven correction was another powerful method; however, the corrected value requires cautious interpretation.
Study on the safety criterion of blasting vibration in adjacent tunnels under hard rock strata based on energy principle
Authors: ZHANG Junru , YAN Zhijian , LIU Jiaming , WANG Zhiyong , MA Kaimeng , MA Jianchi , WANG Bo 
Published: November 2022

Abstract
This study addresses the contradiction between the strict requirements of vibration speed control in existing operating tunnels and the difficulties of tunnel excavation in hard rock strata, as well as the lack of theoretical basis for blasting vibration speed control standards in adjacent tunnels. Based on the energy principle, this study establishes the energy balance equation in a single cycle of the low frequency band of blasting vibration wave curve, and proposes to replace the maximum elastic strain energy accumulated in concrete by twice the kinetic energy corresponding to the peak vibration speed under blasting action (the "Twice the Peak Kinetic Energy Method") according to the conversion relationship between the input energy of concrete mass unit and the elastic strain energy and kinetic energy. On the basis of this method, the formulae of safe vibration velocity of blasting in two states were derived by combining the energy criteria corresponding to the damage and destruction states of concrete. It is verified in a new tunnel under existing operating railway section in hard rock stratum in Xiamen area. The results show that the maximum principal stress and displacement reach the maximum value in the cycle when the peak vibration speed decays close to zero for the first time in the low frequency band; the elastic strain energy also reaches the maximum value in the cycle when the kinetic energy decays close to zero; affected by a small amount of dissipation energy, the kinetic energy corresponding to the peak vibration speed is slightly less than twice the maximum elastic strain energy, which verifies the reasonableness of the theoretical analysis. Finally, the safe vibration speed corresponding to different concrete grades is given based on the design value of tensile strength.
Bioinformatics analysis and experimental validation of cuproptosis- related lncRNA LINC02154 in clear cell renal cell carcinoma
Authors: Shen Junlin , Wang Linhui , Bi Jianbin 
Published: November 2022

Abstract
Background
Clear cell renal cell carcinoma (ccRCC) is very common in urinary system tumors. Cuproptosis is a non-apoptotic cell death pathway. Copper binds to fatty acylated mitochondrial proteins and activates various forms of cell death. LncRNA LINC02154 is significantly highly expressed in cells and tissues of many types of tumors, and the risk signature of LINC02154 in some tumors has been validated for effectiveness.
Methods
We constructed a risk prognostic signature by obtaining differentially expressed long non-coding RNAs (lncRNAs) associated with ccRCC outcomes and cuproptosis from The Cancer Genome Atlas (TCGA). We used TCGA to construct training and testing sets to analyze the risk signature and the impact of LINC02154, and we performed relevant survival analyses. Tumor mutational burden were analyzed in different LINC02154 expression groups and risk score groups. We next analyzed the immune microenvironment of LINC20154. We performed LINC20154-related drug sensitivity analyses. We also investigated the cellular function of LINC02154 in the ACHN cell line and performed CCK-8 assay, EdU, wound-healing assay, and Transwell assay
Results
We demonstrated that LINC02154’s impact on outcomes was statistically significant. We also demonstrated the association of different ages, genders, stages, and grades with LINC02154 and risk models. The results showed that there was a significant difference in tumor mutation burden between the groups, and this difference was closely related to clinical prognosis. We found differences in immune cells among groups with different levels of LINC02154 expression and significant differences in immune function, immunotherapeutic positive markers, and critical steps of the immune cycle. The sensitivity analysis was showed that differential expression of LINC02154 discriminated between sensitivity to axitinib, doxorubicin, gemcitabine, pazopanib, sorafenib, sunitinib, and temsirolimus. This difference was also present in the high risk group and low risk group. We demonstrated the proliferation and migration of t ACHN cells in the LINC02154 knockdown group were inhibited.
Conclusion
Finally, we demonstrated that LINC02154 and our constructed risk signature can predict outcomes and have potential clinical value.
Socioeconomic inequality in teenage pregnancy in Papua New Guinea: A decomposition analysis
Authors: Li Hao , Pu Yiran , Li Zhen , Jin Ziyang , Jiang Yi 
Published: November 2022

Abstract
Background: Teenage pregnancy is a global public health issue, and it poses a serious threat to the health and socioeconomic status of mothers and their newborn children. Although Papua New Guinea (PNG) has recorded one of the highest teenage pregnancy rates among Asia-Pacific countries, no study has been conducted on socioeconomic inequality in teenage pregnancy in this country. Therefore, this study aimed to access socioeconomic inequality in teenage pregnancy and its contributing factors in PNG.
Methods: Data for this cross-sectional study were obtained from the 2016–2018 Papua New Guinea Demographic and Health Survey. The analytical sample consisted of 2,874 girls aged 15–19 years. We employed Erreygers normalized concentration index (ECI) and concentration curves to measure and depict socioeconomic inequality in teenage pregnancy. Decomposition analysis was likewise performed to identify the contributions of determinants to the observed inequality.
Results: Weighted ECI for teenage pregnancy was −0.059 (P < 0.01), thereby indicating that teenage pregnancy in PNG is disproportionately concentrated among poor girls. Decomposition analysis suggested that education level (90.5%), wealth index (38.6%), and region (11.1%) are the main determinants explaining the pro-poor socioeconomic inequality in teenage pregnancy.
Conclusions: A pro-poor socioeconomic inequality of teenage pregnancy was present in PNG. This inequality may be alleviated by such interventions as ensuring that teenage girls receive education; implementing poverty alleviation projects, eliminating child, early, and forced marriages; and improving geographical accessibility to health facilities on contraceptive services.
Post-processing of a nine-axis and five-linkage turn-milling composite machine tool
Authors: Wei Wei , Tang Qingchun , Zhang Chenyang , Wang Taizi , Pan Yingguang , Wang Yutao 
Published: November 2022

Abstract
Post-processing is an important technology in transferring information between CAM software and CNC system. At present, the traditional five-axis machine tool cannot satisfy the requirements of high precision and efficiency in the manufacture of complex parts due to its single function. The auxiliary rotary spindle, auxiliary linear axis, and power tool rest are added on the basis of the traditional five-axis machine tool to solve the technical bottleneck problem. Thus, the machine tool with the composite function of turning and milling is established. The control of the motion chain and the numerical control system of the turn-milling composite machine tool is more complex than that of the traditional five-axis machine tool, and the development of the post-processing is also more difficult. This study investigates the development of post-processing of a nine-axis five-linkage turn-milling composite machine tool (PUMASMX2600ST). First, the kinematic chain and coordinate system of the turning and milling function are established, respectively, according to the function division of the machine tool, and the inverse kinematic model is solved by the kinematic coordinate transformation. Second, a special post-processing software with turning and milling functions is developed using Visual Basic language. Finally, a type of blade root milling tool is used as the specimen for simulation and actual cutting verification. Experiments show that the special processor is correct and reasonable, and it can satisfy the requirements of the machine tool.
Ginger essential oil and citral ameliorate atherosclerosis via modulating TMAO and gut microbiota in ApoE−/− mice fed on Gubra amylin NASH diet with ʟ-carnitine
Authors: Sheen Lee-Yan , Panyod Suraphan , Wu Wei-Kai , Peng Sin-Yi , Tseng Yea-Jing , Hsieh Ya-Chi , Chen Rou-An , Huang Huai-Syuan , Chen Yi-Hsun , Chuang Hsiao-Li , Hsu Cheng-Chih , Shen Ting-Chin David , Yang Kai-Chien , Ho Chi-Tang , Wu Ming-Shiang 
Published: November 2022

Abstract
Gut microbiota and its metabolites, along with host metabolism of ʟ-carnitine, play a crucial role in cardiovascular disease (CVD) development, forming Trimethylamine-N-oxide (TMAO), an atherosclerosis risk factor. TMAO promotes the formation of atherosclerotic plaques and platelet aggregation potential, causing thrombosis. A high-fat diet and carnitine administration can accelerate CVD progression. Ginger (Zingiber officinale Roscoe) essential oil (GEO) and its bioactive compound citral have lipid lowering and anti-inflammatory effects, which may prevent CVD; however, their ability to prevent atherosclerosis through gut microbiota modulation remains to be elucidated. Furthermore, the Gubra Amylin NASH (GAN) diet is a palm oil-containing high-fat diet for inducing steatohepatitis; however, the study of the GAN diet in combination with ʟ-carnitine for inducing atherosclerosis in mouse model has not been investigated yet. We examined the CVD-protecting effect of GEO and citral against the formation of aortic atherosclerosis and linked them with changes in the gut microbiota and its metabolites in the ʟ-carnitine/GAN diet-treated apolipoprotein E-deficient (ApoE−/−) mouse model. GEO and citral demonstrated CVD protective function by alleviating aortic atherosclerotic lesions. They reduced blood sugar, improved insulin resistance, decreased plasma TMAO levels, and inhibited serum inflammatory cytokines, especially interleukin-1β. Moreover, they demonstrated their ability to modulate gut microbiota diversity and composition into a favourable direction. Collectively, GEO and citral may serve as potential prebiotics for CVD prevention by improving dysbiosis.
In Situ single-crystal synchrotron X-ray Diffraction Studies of Biologically Active Gases in Metal-Organic Frameworks
Authors: Main Russell , Vornholt Simon , Rice Cameron , Elliott Caroline , Russell Samantha , Kerr Peter , Warren Mark , Morris Russell 
Published: November 2022

AbstractMetal-organic frameworks (MOFs) are well known for their ability to adsorb various gases. The use of MOFs for the storage and release of biologically active gases, particularly nitric oxide (NO) and carbon monoxide (CO), has been a subject of interest. To elucidate the binding mechanisms and geometry of these gases, anin situsingle crystal X-ray diffraction (scXRD) study using synchrotron radiation at Diamond Light Source has been performed on a set of MOFs that display promising gas adsorption properties. NO and CO, were introduced into dehydrated Ni-CPO-27 and the related Co-4,6-dihydroxyisophthalate (Co-4,6-dhip). Both MOFs show strong binding affinity towards CO and NO, however CO suffers more from competitive co-adsorption of water. Additionally, we show that morphology can play an important role in the ease of dehydration for these two systems.
Diabetes mellitus affects the treatment outcomes of drug-resistant tuberculosis: A systematic review and meta-analysis
Authors: Xu Guisheng , Hu Xiaojiang , Lian Yanshu , Li Xiuting 
Published: November 2022

Abstract
Background
Both tuberculosis (TB) and diabetes mellitus (DM) are major public health problems threatening global health. Drug-resistant TB (DR-TB) and impaired immunity caused by DM make controlling TB more difficult.
Methods
We searched PubMed, Excerpta Medica Database (EMBASE), Web of Science, ScienceDirect and Cochrance Library for literature published in English until July 2022. Papers were limited to those reporting the association between DM and treatment outcomes among DR-TB and multidrug-resistant TB (MDR-TB) patients. The strength of association was presented as odds ratios (ORs) and their 95% confidence intervals (CIs) using the fixed-effects or random-effects models. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were followed for the analysis.
Results
A total of twenty-five studies involving 16,905 DR-TB patients were included in the meta-analysis, of which 10,124 (59.88%) participants were MDR-TB patients, and 1,952 (11.54%) had DM history. In DR-TB patients, the pooled OR was 1.56 (95% Cl: 1.24–1.96) for unsuccessful outcomes, 0.64 (95% Cl: 0.44–0.94) for cured treatment outcomes, 0.63 (95% Cl: 0.46–0.86) for completed treatment, and 1.28 (95% Cl: 1.03–1.58) for treatment failure. Among MDR-TB patients, the pooled OR was 1.57 (95% Cl: 1.20–2.04) for unsuccessful treatment outcomes, 0.55 (95% Cl: 0.35–0.87) for cured treatment outcomes, 0.66 (95% Cl: 0.46–0.93) for completed treatment and 1.37 (95% Cl: 1.08–1.75) for treatment failure.
Conclusion
DM is a risk factor for adverse outcomes of DR-TB or MDR-TB patients. Controlling hyperglycemia may contribute to the favourable prognosis of TB.
Maternal Satisfaction with Labor and Delivery Services and Associated Factors Among Post-Partum Women in East-Gojjam Zone Primary Hospitals, Amhara-Ethiopia: Cross- sectional study
Authors: Abate Enyew , Mengist Tilaye , Debalkie Desta 
Published: November 2022

Abstract
Background: Globally, approximately 810 women die from preventable causes related to pregnancy and childbirth every day. Mothers’ delivery care satisfaction is one of the indicators to monitor the quality of health care provision and secondary prevention of maternal mortality. However, there is only limited information in the study area. The objective of this study is to determine the level of maternal satisfaction and associated factors among women who came for labor and delivery services.
Methods: A facility-based cross-sectional study was conducted among 600 mothers in the Maternity ward of the three primary Hospitals in East-Gojjam-Ethiopia from March to May, 2022. The data was collected using a structured interviewer-administered questionnaire using a systematic random sampling technique. Data were entered into Epi data v 3.1, transported and analyzed using SPSS version 23.0. Binary logistic regression analysis was done to assess the statistical association between dependent and independent variables and variables having p-value less than or equal to 0.25 in binary logistic regression analysiwereas entered into multivariate logistic regression analysis for identifying determinants of maternal satisfaction on delivery services using a p value of 0.05 and 95 % confidence level.
Results: The overall maternal satisfaction level with the delivery services at the study hospitals was 85%. Having perceived cleanliness of the delivery room (AOR=13, 95% CI: 2.3, 59.8) and availability of drugs (AOR=3.659, 95%CI: 1.382, 9.69) were positively associated with maternal satisfaction on delivery service. Mothers who did not attend formal education were more likely satisfied with delivery service compared with those mothers whose educational status was diploma and above (AOR=0.056, 95% CI: 0.007, 0.431).
Conclusions: The overall level of client satisfaction with the delivery services was found to be suboptimal and could be improved. Cleanliness of the delivery room, availability of drugs and supplies, and educational status were significantly associated with predictors of maternal satisfaction. The health system should be devised to increase maternal satisfaction the health institutions and provide maternal-friendly services.