bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Importance of “Community” in the Process of Immigrant Assimilation
Authors: Fitzpatrick Joseph P. 
Published: January 2022

L'auteur accepte la position que les relations exprimées dans le concept de “communauté” jouent un rôle décisif dans le processus de l'assimilation culturelle, en accordant a l'immigré une base de sécurité, de paix, et de satisfaction psychologique durant la période d'adaptation à la nouvelle société. Il examine les concepts d'assimilation et de communauté comme ils sont acceptés dans les plus récentes études américaines, et il prouve l'utilité du concept de communauté dans l'analyse du processus de l'assimilation. L'apport spécifique de l'article du Prof. Fitzpatrick consiste surtout à faire remarquer que le concept de communauté, dans le sens accepté actuellement, et la signification de la communauté dans le processus d'assimilation a encore besoin d'un plus grand éclaircissement pour rendre l'idée plus précise. Ainsi, son application aux études des communautés d'immigrés sera plus efficace. L'auteur suggère spécialement que la ligne de démarcation de la communauté soit plus précisement identifiée, en employant quelques unes des plus récentes méthodes d'étude des différences culturelles; en outre, que les références géographiques soient indiquées et que les liens avec le reste de la communauté soient definis avec soin.
West Indian Migration to Britain
Authors: Peach G. C. K. 
Published: January 2022

Arrivée au debut de l'année 1964, l'émigration des Indes-Occidentales à la Grande retagne comptait environ 300,000 personnes. Après une analyse rigoureuse sur cette migration, l'auteur déduit que les chiffres donnent une preuve certaine que les Indiens-Occidentaux servaint de remplaçants dans le monde ouvrier. Il n'est pas dit que cette situation soit toujours telle et que tous les Indiens-Occidentaux ont été attirés comme remplaçants d'ouvriers introuvable de race blanche, mais que cette hypothèse décrit clairement les conditions générales de mouvement, de la distribution, et d'employ des Indiens-Occidentaux en Grande Bretagne et au Pays de Galles. Bien que ce mouvement ait effectué un bienfait économique pour la Grande Bretagne, du point de vue social, cela n'a pas été commode à cause du manque de logements, d'organisations scolaires et du heurt occasionné par larrivée d'une minorité visible dans quelques régions souffrant de difficultés sociales de longue date.
The Contribution of Posterior Capsule Hypertrophy to Soft Tissue Glenohumeral Internal Rotation Deficit in Healthy Pitchers
Authors: Paul Ryan W. , Sheridan Scott , Reuther Katherine E. , Kelly John D. , Thomas Stephen J. 
Published: January 2022

Background: The relationship between posterior capsule adaptations and soft tissue glenohumeral internal rotation deficit (GIRD) in healthy pitchers remains unclear. Purpose/Hypothesis: This study aimed to identify if posterior capsule thickness (PCT) was associated with soft tissue GIRD in healthy pitchers. We hypothesized that there would be a positive relationship between soft tissue GIRD and PCT in the dominant arm, no relationship between soft tissue GIRD and PCT in the nondominant arm, and a strong positive relationship between soft tissue GIRD and the bilateral difference in PCT (posterior capsule hypertrophy [PCH]). Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 45 healthy collegiate and professional pitchers were included. Glenohumeral internal rotation and external rotation range of motion, humeral retroversion, and PCT were measured bilaterally. PCT was determined for unilateral posterior capsule measurements, and PCH of the throwing shoulder was calculated as the bilateral difference in PCT. Soft tissue GIRD was calculated as the sum of clinical GIRD and the bilateral difference in humeral retroversion. Pearson correlation coefficients were determined to evaluate the relationships between dominant arm PCT, nondominant arm PCT, and PCH and soft tissue GIRD. Results: Pearson correlations showed that both dominant arm PCT ( R = −0.13; P = .378) and nondominant arm PCT ( R = 0.21; P = .165) were not related to soft tissue GIRD. However, Pearson correlations did show that the amount of PCH was moderately related to soft tissue GIRD ( R = 0.40; P = .007). Therefore, as the posterior capsule hypertrophied, soft tissue GIRD moderately increased. Conclusion: Increased PCH was associated with an increase in soft tissue GIRD in healthy pitchers. If PCT measurements are feasible, clinicians should consider performing bilateral ultrasound assessments to isolate posterior capsule adaptations (ie, PCH). This will allow clinicians to identify pitchers with potentially maladaptive structural adaptations and optimize management strategies throughout the season to counteract them.
Intrafamilial Variability of the R694C Variant in BICD2 Presenting with Lethal Severe Arthrogryposis
Authors: Ribeiro-Mourão Francisco , Vilan Ana , Passos-Silva Sara , Silveira Fernando , Leão Miguel , Sampaio Mafalda 
Published: January 2022

Arthrogryposis multiplex congenita (AMC) is a heterogeneous condition comprising congenital multiple joint contractures, and it is secondary to decreased fetal mobility following environmental/genetic abnormalities. BICD2 pathogenic variants have been associated with autosomal dominant spinal muscular atrophy with lower extremity predominance (SMALED2). We report the case of a newborn with decreased fetal movements and ventriculomegaly diagnosed in utero, born with severe AMC, multiple bone fractures, congenital hip dislocation, and respiratory insufficiency that led to neonatal death. His mother had AMC diagnosis without established etiology. Her phenotype characterization was key to guide the genetic investigation. A BICD 2 heterozygous variant (NM_001003800.1; c.2080C > T; p. [Arg694Cys]) was detected both in the mother and the newborn. This variant had previously been reported in 3 cases, all having de novo severe SMALED-type 2B (MIM#618291) phenotype. This is the first report of this variant (p. [Arg694Cys]) presenting with an inherited, severe, and lethal phenotype associated to intrafamilial variability, suggesting a more complex phenotype-genotype correlation than previously stated.
Impact of Defibrotide in the Prevention of Acute Graft-Versus-Host Disease Following Allogeneic Hematopoietic Cell Transplantation
Authors: Tilmont Rémi , Yakoub-Agha Ibrahim , Ramdane Nassima , Srour Micha , Coiteux Valérie , Magro Léonardo , Odou Pascal , Simon Nicolas , Beauvais David 
Published: January 2022

Background Defibrotide is indicated for patients who develop severe sinusoidal obstructive syndrome following allogeneic hematopoietic cell transplantation (allo-HCT). Preclinical data suggested that defibrotide carries a prophylactic effect against acute graft-versus-host disease (aGVHD). Objective The purpose of this study was to investigate the effect of defibrotide on the incidence and severity of aGVHD. Methods This single-center retrospective study included all consecutive transplanted patients between January 2014 and December 2018. A propensity score based on 10 predefined confounders was used to estimate the effect of defibrotide on aGVHD via inverse probability of treatment weighting (IPTW). Results Of the 482 included patients, 64 received defibrotide (defibrotide group) and 418 did not (control group). Regarding main patient characteristics and transplantation modalities, the two groups were comparable, except for a predominance of men in the defibrotide group. The median age was 55 years (interquartile range [IQR]: 40-62). Patients received allo-HCT from HLA-matched related donor (28.6%), HLA-matched unrelated donor (50.8%), haplo-identical donor (13.4%), or mismatched unrelated donor (7.0%). Stem cell source was either bone marrow (49.6%) or peripheral blood (50.4%). After using IPTW, exposure to defibrotide was not significantly associated with occurrence of aGVHD (HR = 0.97; 95% CI 0.62-1.52; P = .9) or occurrence of severe aGVHD (HR = 1.89, 95% CI: 0.98-3.66; P = .058). Conclusion and Relevance Defibrotide does not seem to have a protective effect on aGVHD in patients undergoing allo-HCT. Based on what has been reported to date and on these results, defibrotide should not be considered for the prevention of aGVHD outside clinical trials.
Biomarkers of everolimus efficacy in breast cancer therapy
Authors: Voutsadakis Ioannis A. 
Published: January 2022

Objective Everolimus is an inhibitor of serine/ threonine kinase mTOR. The drug is approved for the treatment of metastatic ER positive, HER2 negative breast cancers and benefits a subset of patients with these breast cancers in combination with hormonal therapies. Despite extensive efforts, no additional predictive biomarkers to guide therapeutic decisions for everolimus have been introduced in clinical practice. Data sources This paper discusses predictive biomarkers for everolimus efficacy in breast cancer. A search of the medline and web of science databases was performed using the words “everolimus” and “biomarkers”. References of retrieved articles were manually scanned for additional relevant articles. Data Summary Everolimus benefits a subset of patients with metastatic ER positive, HER2 negative breast cancers in combination with hormonal therapies. Despite extensive efforts no additional predictive biomarkers to guide therapeutic decisions for everolimus therapy have been confirmed for use in clinical practice. However, promising biomarker leads for everolimus efficacy in breast cancer have been suggested and include expression of proteins in the mTOR pathway in ER positive, HER2 negative breast cancers. In HER2 positive cancers PIK3CA mutations, and PTEN expression loss are prognostic. Other clinical predictive biomarkers with more limited data include characteristics derived from whole genome sequencing, subsets of circulating leukocytes and changes in Standardized Uptake Values (SUV) of Positron Emission Tomography (PET) scans. Conclusions Putative predictive biomarkers for everolimus efficacy in breast cancer patients, both genomic and clinical, deserve further study and could lead to a better selection of responsive patients.
Co-existing lacrimal drainage anomalies in eyes with congenital Glaucoma
Authors: Senthil Sirisha , Ali Mohammad Javed , Chary Raghava , Mandal Anil K 
Published: January 2022

Aim To evaluate the occurrence of co-existing congenital nasolacrimal duct obstruction (CNLDO) and other lacrimal anomalies in eyes with congenital glaucoma (CG). Methods Retrospective analysis of children aged ≤1-year with co-existing CG and CNLDO seen between 1998 and 2019, treatment interventions and outcomes. Results During the study period, 1993 children had CG and 6203 children had CNLDO, among the children aged 1-year or less. Of these, 51 children (73 eyes) had co-existing CG and CNLDO. The prevalence of CNLDO in CG was 2.5% (51/1993) and the prevalence of CG among CNLDO was 0.8% (51/6203). Median age (Interquartile range, IQR) was 53 days (IQR: 8, 155), when they were diagnosed with CG. Among the children with CNLDO, 68 eyes (93.1%) had simple CNLDO, and 5 eyes (6.9%) had complex CNLDO. Associated lacrimal anomalies were present in 7/73 eyes, including congenital lacrimal fistula in two eyes, upper punctal agenesis and upper mid-canalicular obstruction in two eyes each, and upper single canalicular-wall hypoplasia in one eye. Lacrimal syringing and probing were successful in 69/72 eyes (95.8%), and failed in 3 eyes (4.2%). These 3 eyes had complex CNLDO and underwent Dacryocystorhinostomy (DCR) with Mitomycin-C and intubation. Sixty-two eyes underwent combined trabeculotomy and trabeculectomy, and two eyes underwent trabeculectomy. Median age at glaucoma surgery was 87 days (IQR: 54, 193). Median time delay for glaucoma surgery after probing was 18 days (IQR: 12, 35). Conclusion Among children aged ≤1-year presenting with congenital glaucoma coexisting lacrimal drainage anomalies was noted in 2.5% and simple CNLDO was the commonest. Early intervention is of paramount importance to prevent sight-threatening intraocular infection with CNLDO, and to minimize the delay of glaucoma surgery. The outcomes of lacrimal probing were excellent, however complex CNLDO required DCR.
A new polyurethane-steel honeycomb composite pier anti-collision device: Concept and compressive behavior
Authors: Zhang Liwen , Xie Zhujian , Li Jing , Zhang Junping , Yu Qinglun , Zhang Chaoxi 
Published: January 2022

A new type of pier anti-collision composite structure composed of honeycomb steel and polyurethane (PU) elastomer was proposed in this study. The impacts of the shape and filling materials of inner core cells on the failure mode, load–displacement cure, bearing capacity, structural stability, and energy absorption were studied by conducting uniaxial compression tests on device segments. Test results showed that the bearing capacity, structural stability, and energy absorption of honeycomb steel structure were significantly improved by PU elastomer filling. Besides, when compared with the square honeycomb structure and the regular hexagon honeycomb structure, the maximum values of average load, total energy absorption (TEA), and specific energy absorption (SEA), which were 69.6 kN, 1986.1 J, and 1300 J/kg, respectively, for the regular triangle honeycomb structure without PU filling, increased to 459.3%, 376.38%, and 212.5%, respectively, for the regular hexagonal core cell structure with PU filling, which was proved to be the most suitable core structure for pier anti-collision device.
Flexural behaviour of geopolymer concrete beams reinforced with BFRP and GFRP polymer composites
Authors: Subramanian Nagajothi , Solaiyan Elavenil , Sendrayaperumal Angalaeswari , Lakshmaiya Natrayan 
Published: January 2022

The paper presents the experimental investigations on the flexural behaviour of geopolymer concrete beams reinforced with Basalt Fibre Reinforced Polymer (BFRP)/Glass Fibre Reinforced Polymer (GFRP) rebars and the effect of inclusion of the new adhesively bonded BFRP/GFRP stirrups. M30 grade geopolymer and conventional concrete beams with the dimension of 100 × 160 × 1700 mm were cast to investigae the flexural behaviour of BFRP/GFRP and steel bars. This study also examined the mode of failure, deflection behaviour, curvature moment capacity, crack width, pattern, propagation, strains and average crack width of the BFRP/GFRP bars with stirrups in the geopolymer concretes using a four-point static bending test. The results were compared to that of conventional steel-reinforced concrete, and it was found that the Basalt and Glass reinforced polymer beams demonstrated premature failure and sudden shear failure. Further, the FRP bars exhibited higher mid-span deflection, crack width and crack propagation than steel bars. Crack spacing of the FRP bars decreased with an increase in the number of cracks. The correlation between the load and the deflection behaviour of the beams was determined using statistical analysis of multi variables regression.
Squamous Cell Carcinoma of the Foot Occurring in a Wart
Authors: Ogunlana Oluwatosin , Panchbhavi Vinod K. , Norbury William B. , Raji Mukaila 
Published: January 2022

Verrucous carcinoma is a rare form squamous cell carcinoma which appears similar to a wart. When it occurs in the feet, it can be easily misdiagnosed. It rarely metastasizes or recurs posttreatment. We report a case of a septuagenarian with recurrence of verrucous carcinoma diagnosed within 6 months at the site of previous treatment. Unique features in our patient’s clinical presentation include his advanced age, being nondiabetic, and the rapid recurrence of carcinoma. Level of Evidence: Level IV: Case report
Association of Acute Perioperative Myocardial Injury With All-Cause Mortality Within 90 Days After Hip Fracture Repair in the Elderly: A Prospective Study
Authors: Wang Lei , Cai Meng , Li Xiaoying , Deng Xiaohui , Xue Qiang , Zhou Li , Yang Minghui 
Published: January 2022

Introduction It remains unclear whether acute perioperative myocardial injury (APMI) increases mortality in the elderly. This study aimed to investigate APMI’s association with mortality within 90 days after hip fracture repair in elderly patients. Materials and Methods This prospective study enrolled elderly patients admitted to the department of Traumatology and Orthopaedics in XXX Hospital, who underwent surgery in 2018–2019 with a 90-day follow-up. According to survival status within 90 days, survival and death groups were constituted. Clinical, demographic, and laboratory indicators and 90-day mortality post-surgery were recorded. APMI’s association with 90-day mortality post-surgery was analyzed by logistic regression. Results Totally 248 participants were enrolled, including 224 and 24 in the survival and death groups, respectively, for a mortality rate of 9.7%. Compared with surviving individuals, the death group was older [81 (75–86) vs 87 (82–89) years], and had higher incidence rates of APMI (24.6% vs 58.3%), intertrochanteric fractures (41.1% vs 62.5%), preoperative atrial fibrillation (8.9% vs 29.2%), and dementia (73.7% vs 95.8%) (all P<.05). They also showed higher pre-injury frail scale scores [1 (0–2) vs 3 (1–4)] and Nottingham hip fracture scores (NHFSs) [4 (4–5) vs 6.5 (5–7)], lower Glomerular filtration [62 (46.1–78.6) vs 44.37 (35–61.92) ml/min], and reduced odds of glomerular filtration rate <60 mL/min (75.0% vs 46.9%) (all P < .05). APMI (OR = 3.294, 95% CI: 1.217–8.913) and NHFS (OR = 2.089, 95% CI: 1.353–3.225) independently predicted 90-day mortality post-surgery (all P<.05). Conclusions APMI is associated with increased mortality risk within 90 days after hip fracture repair in elderly patients.
Solitary symbolic play, object substitution and peer role play skills at age 3 predict different aspects of age 7 structural language abilities in a matched sample of autistic and non-autistic children
Authors: Zhao Yiran Vicky , Gibson Jenny Louise 
Published: January 2022

Backgrounds and aims Early symbolic play abilities are closely related to long-term language development for both autistic and non-autistic children, but few studies have explored these relations for different dimensions of pretence and of language. The current study explores carer-reported measures of solitary symbolic play, object substitution and peer role play abilities at age 3, and their respective relations with parent-reported semantics, syntax and narrative abilities at age 7 for both autistic and non-autistic children. Methods We conducted secondary data analyses exploring links between different aspects of pretence and of language on the Longitudinal Study of Australian Children population cohort. We identified 92 autistic children and used propensity score matching to match them with 92 non-autistic children based on demographic and developmental information such as non-verbal IQ and socioeconomic status. We explored concurrent and longitudinal relations using correlation and regression models. Results: Both correlational and hierarchical regression analyses confirmed the significant effects of age 3 symbolic play abilities in facilitating age 7 semantics, syntax and narrative abilities for autistic children. We found that object substitution held most prominent influence, followed by peer role play and solitary symbolic play. In contrast, for non-autistic children, none of the age 3 symbolic play abilities were significant predictors, whereas socioeconomic status at birth and age 3 language abilities held significant influences on their age 7 semantics, syntax and narrative abilities. Conclusion: We discuss the implications of our findings for play interventions targeting language outcomes.
Predicting the pulmonary effects of long-term e-cigarette use: are the clouds clearing?
Authors: Davis Lauren C. , Sapey Elizabeth , Thickett David R. , Scott Aaron 
Published: January 2022

Commercially available since 2007, e-cigarettes are a popular electronic delivery device of ever-growing complexity. Given their increasing use by ex-smokers, smokers and never-smokers, it is important to evaluate evidence of their potential pulmonary effects and predict effects of long-term use, since there has been insufficient time to study a chronic user cohort. It is crucial to evaluate indicators of harm seen in cigarette use, and those potentially unique to e-cigarette exposure. Evaluation must also account for the vast variation in e-cigarette devices (now including at least five generations of devices) and exposure methods usedin vivoandin vitro.Thus far, short-term use cohort studies, combined within vivoandin vitromodels, have been used to probe for the effects of e-cigarette exposure. The effects and mechanisms identified, including dysregulated inflammation and decreased pathogen resistance, show concerning overlaps with the established effects of cigarette smoke exposure. Additionally, research has identified a signature of dysregulated lipid processing, which is unique to e-cigarette exposure.This review will evaluate the evidence of pulmonary effects of, and driving mechanisms behind, e-cigarette exposure, which have been highlighted in emerging literature, and highlight the gaps in current knowledge. Such a summary allows understanding of the ongoing debate into e-cigarette regulation, as well as prediction and potential mitigation of future problems surrounding e-cigarette use.
Exploring alterations in sensory pathways in migraine
Authors: Meylakh Noemi , Henderson Luke A. 
Published: January 2022

AbstractBackgroundMigraine is a neurological disorder characterized by intense, debilitating headaches, often coupled with nausea, vomiting and sensitivity to light and sound. Whilst changes in sensory processes during a migraine attack have been well-described, there is growing evidence that even between migraine attacks, sensory abilities are disrupted in migraine. Brain imaging studies have investigated altered coupling between areas of the descending pain modulatory pathway but coupling between somatosensory processing regions between migraine attacks has not been properly studied. The aim of this study was to determine if ongoing functional connectivity between visual, auditory, olfactory, gustatory and somatosensory cortices are altered during the interictal phase of migraine.MethodsTo explore the neural mechanisms underpinning interictal changes in sensory processing, we used functional magnetic resonance imaging to compare resting brain activity patterns and connectivity in migraineurs between migraine attacks (n = 32) and in healthy controls (n = 71). Significant differences between groups were determined using two-sample random effects procedures (p < 0.05, corrected for multiple comparisons, minimum cluster size 10 contiguous voxels, age and gender included as nuisance variables).ResultsIn the migraine group, increases in infra-slow oscillatory activity were detected in the right primary visual cortex (V1), secondary visual cortex (V2) and third visual complex (V3), and left V3. In addition, resting connectivity analysis revealed that migraineurs displayed significantly enhanced connectivity between V1 and V2 with other sensory cortices including the auditory, gustatory, motor and somatosensory cortices.ConclusionsThese data provide evidence for a dysfunctional sensory network in pain-free migraine patients which may be underlying altered sensory processing between migraine attacks.