bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time trends in socio-economic and geographic-based inequalities in childhood wasting in Guinea over 2 decades: a cross-sectional study
Authors: Zegeye Betregiorgis , Adjei Nicholas Kofi , Olorunsaiye Comfort Z , Ahinkorah Bright Opoku , Ameyaw Edward Kwabena , Budu Eugene , Seidu Abdul-Aziz , Yaya Sanni 
Published: January 2022

Abstract

Background
Today, an estimated 7.3% (50 million) of all children &lt;5 y of age suffer from wasting, with more burden in African countries including Guinea. Investigating inequalities in childhood wasting is essential for designing efficient programs and interventions, but no related evidence exists in Guinea. This study aimed to examine the trends in the prevalence of childhood wasting and the extent of sex, socio-economic and geographic-based disparities in Guinea.

Methods
Data from the 1999, 2005 and 2012 Guinea Demographic and Health Surveys and the 2016 Guinea Multiple Indicator Cluster Survey, with a total of 16 137 children &lt;5 y of age were included for analysis. For inequality analysis, we used the 2019 updated World Health Organization Health Equity Assessment Toolkit (HEAT) software. Inequality was measured using four summary measures (difference [D], population attributable risk [PAR], ratio [R] and population attributable fraction [PAF]) for five equity stratifiers (economic status, education, place of residence, sex and subnational region). We computed 95% confidence intervals (CIs) around the points estimates to measure statistical significance.

Results
The findings revealed a pro-rich (R=1.68 [95% CI 1.11 to 2.24]), pro-urban (PAR=−1.04 [95% CI −1.90 to −0.18]) and subnational region (D=8.11 [95% CI 4.85 to 11.36]) inequalities in childhood wasting across all surveys. Except in 2005, education-based disparities (PAF=−18.2 [95% CI −36.10 to −0.26]) were observed across all survey years, but not sex-based disparities. An approximately constant inequality pattern was seen across all dimensions.

Conclusions
This study showed inequalities in childhood wasting in Guinea with a disproportionately higher risk of wasting among children from disadvantaged subpopulations/mothers, including uneducated, poorest/poor, rural residents and regions. Policies that target disadvantaged populations need to be considered in order to ensure social protection, access to a wholesome diet and universal and quality health services.
Intranasally administered S-MGB-364 displays antitubercular activity and modulates the host immune response to Mycobacterium tuberculosis infection
Authors: Kieswetter Nathan S. , Ozturk Mumin , Hlaka Lerato , Chia Julius Ebua , Nichol Ryan J. O. , Cross Jasmine M. , McGee Leah M. C. , Tyson-Hirst Izaak , Beveridge Rebecca , Brombacher Frank , Carter Katharine C. , Suckling Colin J. , Scott Fraser J. , Guler Reto 
Published: January 2022

Abstract

Background
Previously, we evaluated the intracellular mycobactericidal activity of the minor groove binder, S-MGB-364 against the clinical Mycobacterium tuberculosis (Mtb) strain HN878 in macrophages.

Objectives
To assess the mycobactericidal activity of S-MGB-364 in Mtb-infected mice. Further, we investigated a plausible DNA binding mechanism of action of S-MGB-364.

Methods
The anti-TB and host immune effects of intranasal S-MGB-364 or S-MGB-364 encapsulated in non-ionic surfactant vesicles (NIV) were assessed in Mtb-infected mice by cfu enumeration, ELISA, histology, and flow cytometry. DNA binding was examined using native mass spectrometry and UV-vis thermal melt determination. S-MGB interference with DNA-centric biological events was assessed using a representative panel of Mtb and human topoisomerase I, and gyrase assays.

Results
S-MGB-364 bound strongly to DNA as a dimer, significantly increasing the stability of the DNA:S-MGB complex compared with DNA alone. Moreover, S-MGB-364 inhibited the relaxation of Mtb topoisomerase I but not the human form. In macrophages, S-MGB-364 or S-MGB-364-NIV did not cause DNA damage as shown by the low γ-H2AX expression. Importantly, in the lungs, the intranasal administration of S-MGB-364 or S-MGB-364-NIV formulation in Mtb-infected mice was non-toxic and resulted in a ∼1 log cfu reduction in mycobacterial burden, reduced the expression of proinflammatory cytokines/chemokines, altered immune cell recruitment, and importantly reduced recruitment of neutrophils.

Conclusions
Together, these data provide proof of concept for S-MGBs as novel anti-TB therapeutics in vivo.
Characterizing the effect of incrementally increasing dry bulb temperature on linear and nonlinear measures of heart rate variability in nonpregnant, mid-gestation, and late-gestation sows
Authors: Byrd Christopher J , McConn Betty R , Gaskill Brianna N , Schinckel Allan P , Green-Miller Angela R , Lay Donald C , Johnson Jay S 
Published: January 2022

Abstract
Characterizing the sow physiological response to an increased heat load is essential for effective heat stress mitigation. The study objective was to characterize the effects of a 400-min heating episode on sow heart rate variability (HRV) at different reproductive stages. HRV is a commonly used noninvasive proxy measure of autonomic function. Twenty-seven sows were enrolled in the study according to their gestation stage at time of selection: 1) nonpregnant (NP; n = 7), 2) mid-gestation (MID; 57.3 ± 11.8 d gestation; n = 11), and 3) late-gestation (LATE; 98.8 ± 4.9 d gestation; n = 8). The HRV data utilized in the study were collected from each pig as the dry bulb temperature in the room increased incrementally from 19.84 ± 2.15 °C to 35.54 ± 0.43 °C (range: 17.1–37.5 °C) over a 400-min period. After data collection, one 5-min set of continuous heart rate data were identified per pig for each of nine temperature intervals (19–20.99, 21–22.99, 23–24.99, 25–26.99, 27–28.99, 29–30.99, 31–32.99, 33–34.99, and 35–36.99 °C). Mean inter-beat interval length (RR), standard deviation of r-r intervals (SDNN), root mean square of successive differences (RMSSD), high frequency spectral power (HF), sample entropy (SampEn), short-term detrended fluctuation analysis (DFAα1), and three measures (%REC, DET, LMEAN) derived from recurrence quantification analysis were calculated for each data set. All data were analyzed using the PROC GLIMMIX procedure in SAS 9.4. Overall, LATE sows exhibited lower RR than NP sows (P &lt; 0.01). The standard deviation of r–r intervals and RMSSD differed between each group (P &lt; 0.01), with LATE sows exhibiting the lowest SDNN and RMSSD and NP sows exhibiting the greatest SDNN and RMSSD. Late-gestation sows exhibited lower HF than both MID and NP sows (P &lt; 0.0001), greater DFA values than NP sows (P = 0.05), and greater DET compared to MID sows (P = 0.001). Late-gestation also sows exhibited greater %REC and LMEAN compared to MID (P &lt; 0.01) and NP sows (all P &lt; 0.01). In conclusion, LATE sows exhibited indicators of greater autonomic stress throughout the heating period compared to MID and NP sows. However, temperature by treatment interactions were not detected as dry bulb increased. Future studies are needed to fully elucidate the effect of gestational stage and increasing dry bulb temperature on sow HRV.
Effects of increased ambient temperature and supplemental altrenogest before pregnancy establishment in gilts
Authors: Romoser Matthew R , Bidne Katie L , Baumgard Lance H , Keating Aileen F , Ross Jason W 
Published: January 2022

AbstractHeat stress (HS) mitigation strategies are critically needed to combat the substantial economic effects on animal agriculture. The manifestations of seasonal infertility include delayed puberty onset, reduced conception rates, decreased litter size, and increased wean to estrus interval. To assess the effects of HS during early gestation and evaluate the benefit of supplemental altrenogest (ALT) as a mitigation strategy, 30 crossbred postpubertal gilts (157 ± 11 kg body weight) were subjected to estrous synchronization via 14 d oral administration of ALT. Artificial insemination during estrus was performed, and gilts were then placed into one of four treatment groups: HS (35 ± 1 °C for 12 h/31.60 ± 1 °C for 12 h) with (HSALT, n = 7) or without (HSCON, n = 7) 15 mg/d ALT supplementation or thermal neutral (TN; 20 ± 1 °C) conditions with (TNALT, n = 8) or without (TNCON, n = 8) 15 mg/d ALT supplementation until 12 d post-estrus (dpe). Administrating ALT occurred at 0600 hours from 3 to 12 dpe, and rectal temperatures (TR) and respiration rates (RR) were recorded. Blood was collected via jugular venipuncture on 0, 4, 8, and 12 dpe. Gilts were euthanized humanely at 12 dpe followed by the collection of ovarian tissue, and uterine flushing for conceptus collection. In HS compared with TN gilts, RR and TR were increased (P &lt; 0.01) but unaffected by ALT supplementation. Feed intake was reduced (P &lt; 0.01) by HS but unaltered by the ALT treatment. Corpora lutea (CL) weight was reduced (P &lt; 0.01) in HSCON gilts when compared with TNCON and HSALT gilts despite progesterone concentrations in serum and luteal tissue not being affected by treatment (P ≥ 0.10). CL diameter was reduced (P ≤ 0.05) in HSALT gilts compared with other treatments. Interleukin-1β (IL1B) uterine flush concentration was not affected (P &gt; 0.20) by environment or ALT supplementation, although moderate (P = 0.06) interaction between environment and ALT existed, as IL1B concentration in TNALT was increased (P = 0.03) compared with TNCON gilts. While environment did not affect conceptus development (P = 0.90), ALT supplementation advanced conceptus elongation (P &lt; 0.01). Collectively, these data demonstrate that HS may affect luteal development before pregnancy establishment, and ALT increases conceptus elongation by 12 dpe.
Identifying proteins in the cell by tagging techniques for cryo-electron microscopy
Authors: Kikkawa Masahide , Yanagisawa Haruaki 
Published: January 2022

Abstract
Cryo-electron microscopy (cryo-EM) is currently expanding its application from molecular structures to cellular structures. The cellular environment is heterogeneous, containing many different proteins, and very crowded. This environment is in sharp contrast to the specimens for single particle analysis, by which purified homogeneous samples are analyzed. To answer biological questions from the structural studies of cells, it is crucial to identify biological molecules (typically, proteins) of interest and tagging is becoming the critical technique for cryo-EM. In this review, we explain the requirements for tags and review recent advances of tagging and identification methods for cryo-EM.
Fostering Transdisciplinary Collaborations in Cancer Health Economics Research
Authors: Yu James B 
Published: January 2022

Abstract
Health economics research, defined as research that evaluates how patients, health-care providers, and governments make health-care decisions using economic theory, models, and empirical techniques, requires broad domains of knowledge that are not fully encompassed by a single discipline. Collaboration between disciplines provides different perspectives on problems, creates more comprehensive research questions, allows for more complex understanding of multifaceted determinants and processes, and thus, provides more realistic recommendations to address difficult questions of health economics. Realizing the importance of collaboration, the National Cancer Institute virtual conference on the Future of Cancer Health Economics included an interactive panel exploring how to foster effective collaborations in cancer health economics research. This manuscript summarizes the panel and participants’ discussion regarding the value, barriers, and potential facilitators to transdisciplinary collaboration within health economics research.
Japanese structure survey of radiation oncology in 2015
Authors: Numasaki Hodaka , Nakada Yoshihiro , Okuda Yasuo , Ohba Hisateru , Teshima Teruki , Ogawa Kazuhiko ,   Japanese Society for Radiation Oncology Database Committee
Published: January 2022

Abstract
This article describes the ongoing structure of radiation oncology in Japan in terms of equipment, personnel, patient load and geographic distribution to identify and overcome any existing limitations. From May 2016 to August 2018, the Japanese Society for Radiation Oncology conducted a questionnaire based on the Japanese national structure survey of radiation oncology in 2015. Data were analyzed based on the institutional stratification by the annual number of new patients treated with radiotherapy per institution. The estimated annual numbers of new and total (new plus repeat) patients treated with radiation were 225 000 and 271 000, respectively. Additionally, the estimated cancer incidence was 891 445 cases with approximately 25.2% of all newly diagnosed patients being treated with radiation. The types and numbers of treatment devices actually used included linear accelerator (linac; n = 936), Gamma Knife (n = 43), 60Co remote afterloading system (RALS; n = 21), and 192Ir RALS (n = 129). The linac system used dual-energy functions in 754 units, 3D conformal radiotherapy functions in 867, and intensity-modulated radiotherapy (IMRT) functions in 628. There were 899 Japan Radiological Society/Japanese Society for Radiation Oncology-certified radiation oncologists (RO), 1213.9 full-time equivalent (FTE) ROs, 2394.2 FTE radiotherapy technologists (RTT), 295.7 FTE medical physicists, 210.2 FTE radiotherapy quality managers, and 906.1 FTE nurses. The frequency of IMRT use significantly increased during this time. In conclusion, the Japanese structure of radiation oncology has clearly improved in terms of equipment and utility although there was a shortage of personnel in 2015.
Phytomelatonin: an unexpected molecule with amazing performances in plants
Authors: Arnao Marino B , Cano Antonio , Hernández-Ruiz Josefa 
Published: January 2022

AbstractPhytomelatonin, a multifunctional molecule that has been found to be present in all plants examined to date, has an important role in plants as a modulatory agent (a biostimulator) that improves plant tolerance to both biotic and abiotic stress. We present a review of phytomelatonin that considers its roles in plant metabolism and in particular its interactions with plant hormone network. In the primary metabolism of plants, melatonin improves the rate and efficiency of photosynthesis, as well related factors such as stomatal conductance, intercellular CO2, and Rubisco activity. It has also been shown to down-regulate some senescence transcription factors. Melatonin up-regulates many enzyme transcripts related to carbohydrates (including sucrose and starch), amino acids, and lipid metabolism, optimizing N, P, and S uptake. With respect to the secondary metabolism, clear increases in polyphenol, glucosinolate, terpenoid, and alkaloid contents have been described in numerous melatonin-treated plants. Generally, the most important genes of these secondary biosynthesis pathways have been found to be up-regulated by melatonin. The great regulatory capacity of melatonin is a result of its control of the redox and plant hormone networks. Melatonin acts as a plant master regulator, up-/down-regulating different plant hormone levels and signalling, and is a key player in redox homeostasis. It has the capacity to counteract diverse critical situations such as pathogen infections and abiotic stresses, and provide plants with varying degrees of tolerance. We propose possible future applications of melatonin for crop improvement and post-harvest product preservation.
Combating the Current Pandemic and Preparing for the Next: Lessons Learned From the COVID-19 Pandemic From the Perspective of Deployed Special Operations Forces
Authors: Scheiber Christopher J , Simmons Lemar M , Neading Richard D , Becker Casey F , Scarborough Tyler R , Lenn David G , Moreno Peter , Brown Dixon S , Griffiths Dylan M , Pearson Jeffrey A , Hamm Andrew R , Tucker Anthony A , Monson Michael J E 
Published: January 2022

ABSTRACT
The coronavirus 2019 (COVID-19) pandemic continues to be a threat to global health, including the health of deployed armed forces. Servicemembers had to adjust to the “new normal” while maintaining the interests of the nation’s security as well as that of our host nation partners. This commentary examines how Special Operations Forces operating within four different regions worldwide leveraged the challenges presented by the onset of this pandemic in maintaining stability, sustaining a ready force, and operating forward deployed. Deployed forces face constant difficulties with logistical support, varied medical resources access and a medical system predominantly focused on trauma care. At the onset of the COVID-19 pandemic there was little guidance specific to these circumstances which required an improvised adaptation of the recommendations set by national and Department of Defense medical authorities. Plans were constantly revised to match the ever changing medical and operational environment. Strategies such as the “Bubble Philosophy” and tiered force protection measures helped our units to maintain a rigorous training cycle. New methods of communication and training with our host nation partners such as the use of Unmanned Aerial Systems (UAS) platforms to survey host nation training became standard. Through these measures all of our forces were able to maintain operational capacity, protect the force, and maintain rapport with the host nations. We hope these experiences will provide a rough framework for future forces faced with a similar struggle. We also want to stress that challenges vary depending on the area of operations and the pathogen responsible for the pandemic. Any feedback and collaboration that may come from this work is appreciated and encouraged.
Energy functions of fast radio bursts derived from the first CHIME/FRB catalogue
Authors: Hashimoto Tetsuya , Goto Tomotsugu , Chen Bo Han , Ho Simon C-C , Hsiao Tiger Y-Y , Wong Yi Hang Valerie , On Alvina Y L , Kim Seong Jin , Kilerci-Eser Ece , Huang Kai-Chun , Santos Daryl Joe D , Yamasaki Shotaro 
Published: January 2022

ABSTRACT
Fast radio bursts (FRBs) are mysterious millisecond pulses in radio, most of which originate from distant galaxies. Revealing the origin of FRBs is becoming central in astronomy. The redshift evolution of the FRB energy function, i.e. the number density of FRB sources as a function of energy, provides important implications for the FRB progenitors. Here, we show the energy functions of FRBs selected from the recently released Canadian Hydrogen Intensity Mapping Experiment (CHIME) catalogue using the Vmax method. The Vmax method allows us to measure the redshift evolution of the energy functions as it is without any prior assumption on the evolution. We use a homogeneous sample of 164 non-repeating FRB sources, which are about one order of magnitude larger than previously investigated samples. The energy functions of non-repeating FRBs show Schechter function-like shapes at z ≲ 1. The energy functions and volumetric rates of non-repeating FRBs decrease towards higher redshifts similar to the cosmic stellar-mass density evolution: there is no significant difference between the non-repeating FRB rate and cosmic stellar-mass density evolution with a 1 per cent significance threshold, whereas the cosmic star-formation rate scenario is rejected with a more than 99 per cent confidence level. Our results indicate that the event rate of non-repeating FRBs is likely controlled by old populations rather than young populations that are traced by the cosmic star-formation rate density. This suggests old populations, such as old neutron stars and black holes, as more likely progenitors of non-repeating FRBs.
Discovery of 74 new bright ZZ Ceti stars in the first three years of TESS
Authors: Romero Alejandra D , Kepler S O , Hermes J J , Amaral Larissa Antunes , Uzundag Murat , Bognár Zsófia , Bell Keaton J , VanWyngarden Madison , Baran Andy , Pelisoli Ingrid , Oliveira Gabriela da Rosa , Koester Detlev , Klippel T S , Fraga Luciano , Bradley Paul A , Vučković Maja , Heintz Tyler M , Reding Joshua S , Kaiser B C , Charpinet Stéphane 
Published: January 2022

ABSTRACT
We report the discovery of 74 new pulsating DA white dwarf stars, or ZZ Cetis, from the data obtained by the Transiting Exoplanet Survey Satellite mission, from Sectors 1 to 39, corresponding to the first 3 cycles. This includes objects from the Southern hemisphere (Sectors 1–13 and 27–39) and the Northern hemisphere (Sectors 14–26), observed with 120 s- and 20 s-cadence. Our sample likely includes 13 low-mass and one extremely low-mass white dwarf candidate, considering the mass determinations from fitting Gaia magnitudes and parallax. In addition, we present follow-up time series photometry from ground-based telescopes for 11 objects, which allowed us to detect a larger number of periods. For each object, we analysed the period spectra and performed an asteroseismological analysis, and we estimate the structure parameters of the sample, i.e. stellar mass, effective temperature, and hydrogen envelope mass. We estimate a mean asteroseismological mass of 〈Msis〉 = 0.635 ± 0.015 M⊙, excluding the candidate low or extremely low-mass objects. This value is in agreement with the mean mass using estimates from Gaia data, which is 〈Mphot〉 = 0.631 ± 0.040 M⊙, and with the mean mass of previously known ZZ Cetis of 〈M*〉 = 0.644 ± 0.034 M⊙. Our sample of 74 new bright ZZ Cetis increases the number of known ZZ Cetis by ∼20 per cent.
Transverse oscillations of the incompressible MHD mode in the visco-resistive plasmas: an explanation of Alfvénic to Landau-type characteristics
Authors: Pandey V S , Kumar Ankit , Nayak M K 
Published: January 2022

ABSTRACT
In this paper, we characterize transverse oscillations as either Alfvénic or Landau-type in an incompressible non-ideal magnetohydrodynamic (MHD) fluid. We consider shear viscosity and magnetic diffusivity as dissipation mechanisms to derive a general dispersion relation for the incompressible MHD waves. The solutions of this dispersion relation for k as a function of ω – denoting by the source for any value of θ up to which magnetic tension acts as restoring force and dominates over internal friction forces – result in four roots, as follows. Two roots, which have a high phase velocity $c_{\rm A}\cos\theta $ are identified as almost undamped propagating Alfvén waves. The other two roots, which have a phase velocity $(2c_{\rm A}\cos\theta)/(\sqrt{\eta/\nu} + \sqrt{\nu/\eta})$, result in Alfvénic-type disturbances of a much shorter decay length than the wavelength. In contrast, when internal frictional forces start dominating over magnetic tension (i.e. for the propagation perpendicular to the background magnetic field, where the tension in the magnetic field becomes zero), the solutions of the dispersion are akin to Landau-type transverse oscillations. Transverse waves of this type were initially reported by Landau in an ordinary viscous fluid. However, our study corresponds to MHD visco-resistive fluid. The prediction for these lateral propagating transverse waves to be of Landau type may be very useful to explain the heating of observed filamentary structures across the magnetic field on a very small spatial scale in the solar coronal plasma, wherein the heating rate is directly proportional to the operating frequency of the driver, while its damping length is inversely proportional to the square root of the frequency.