bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hierarchical transfer learning for deep learning velocity model building
Authors: Simon Jérome , Fabien-Ouellet Gabriel , Gloaguen Erwan , Khurjekar Ishan 
Published: October 2022

Deep learning is a promising approach to velocity model building because it has the potential of processing large seismic surveys with minimal resources. By leveraging large quantities of model-gather pairs, neural networks (NNs) can automatically map data to the model space, directly providing a solution to the inverse problem. Such mapping requires big data, which proves prohibitive for 2D and 3D surveys of realistic size. We have developed a transfer learning (TL) strategy. A network is first trained on a smaller subproblem, which then becomes the starting solution to a larger, more difficult data set, akin to the hierarchical multiscale strategy for full-waveform inversion. We perform TL by having subobjectives that escalate in complexity and by first training an NN at estimating horizontally layered velocity models and then proceeding to train an augmented network at estimating 2D dipping layered models. TL improves convergence and allows using a lesser quantity of 2D models for training. For synthetic tests, the structural similarity index measure of 2D interval velocity models in the time domain is [Formula: see text] and the root-mean-square (rms) error is [Formula: see text] m/s. We benchmark our algorithm on the Marmousi2 model and observe that our method can apply to velocity models with continuous deformed layers with dips up to 35°. We benchmark our algorithm on 2D marine field data and produce an rms velocity model that leads to coherent stacking and a time interval velocity model that reproduces salient features of the stacked section. TL expedites and regularizes training and data-driven techniques may be applied to field data with minimal preprocessing even though we lack real target velocity models.
Hospitalization for COVID-19 is associated with a higher risk of subsequent hospitalization for psychiatric disorders: A French nationwide longitudinal study comparing hospitalizations for COVID-19 and for other reasons
Authors: Decio Valentina , Pirard Philippe , Pignon Baptiste , Bouaziz Olivier , Perduca Vittorio , Chin Francis , Le Strat Yann , Messika Jonathan , Kovess-Masfety Viviane , Corruble Emmanuelle , Regnault Nolwenn , Tebeka Sarah 
Published: October 2022

Abstract

Introduction
Although COVID-19 has been associated with psychiatric symptoms in patients, no study to date has examined the risk of hospitalization for psychiatric disorders after hospitalization for this disease.

Objective
We aimed to compare the proportions of hospitalizations for psychiatric disorders in the 12 months following either hospitalization for COVID-19 or hospitalization for another reason in the adult general population in France during the first wave of the current pandemic.

Methods
We conducted a retrospective longitudinal nationwide study based on the national French administrative healthcare database.

Results
Among the 2,894,088 adults hospitalized, 96,313 (3.32%) were admitted for COVID-19. The proportion of patients subsequently hospitalized for a psychiatric disorder was higher for COVID-19 patients (11.09 vs. 9.24%, OR = 1.20 95%CI 1.18–1.23). Multivariable analyses provided similar results for a psychiatric disorder of any type and for psychotic and anxiety disorders (respectively, aOR = 1.06 95%CI 1.04–1.09, aOR = 1.09 95%CI 1.02–1.17, and aOR = 1.11 95%CI 1.08–1.14). Initial hospitalization for COVID-19 in intensive care units and psychiatric history were associated with a greater risk of subsequent hospitalization for any psychiatric disorder than initial hospitalization for another reason.

Discussion
Compared with hospitalizations for other reasons, hospitalizations for COVID-19 during the first wave of the pandemic in France were associated with a higher risk of hospitalization for a psychiatric disorder during the 12 months following initial discharge. This finding should encourage clinicians to increase the monitoring and assessment of psychiatric symptoms after hospital discharge for COVID-19, and to propose post-hospital care, especially for those treated in intensive care.
Positron Emission Tomography–Adapted Therapy in Bulky Stage I/II Classic Hodgkin Lymphoma: CALGB 50801 (Alliance)
Authors: LaCasce Ann S. , Dockter Travis , Ruppert Amy S. , Kostakoglu Lale , Schöder Heiko , Hsi Eric , Bogart Jeffrey , Cheson Bruce , Wagner-Johnston Nina , Abramson Jeremy , Blum Kristie , Leonard John P. , Bartlett Nancy L. 
Published: October 2022

PURPOSE Patients with bulky stage I/II classic Hodgkin lymphoma (cHL) are typically treated with chemotherapy followed by radiation. Late effects associated with radiotherapy include increased risk of second cancer and cardiovascular disease. We tested a positron emission tomography (PET)–adapted approach in patients with bulky, early-stage cHL, omitting radiotherapy in patients with interim PET-negative (PET−) disease and intensifying treatment in patients with PET-positive (PET+) disease. METHODS Eligible patients with bulky disease (mass > 10 cm or 1/3 the maximum intrathoracic diameter on chest x-ray) received two cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by interim fluorodeoxyglucose PET (PET2). Patients with PET2–, defined as 1-3 on the 5-point scale, received four additional cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine. Patients with PET2+ received four cycles of escalated bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone followed by 30.6 Gy involved-field radiation. RESULTS Of 94 evaluable patients, 53% were female with median age 30 years (range, 18-58 years). Eight-five (90%) had stage II disease, including 48 (51%) with stage IIB/IIBE. Seventy-eight (78%) were PET2– and 21 (22%) were PET2+. The predominant toxicity was neutropenia, with 9% of patients developing febrile neutropenia and one developing sepsis. The primary end point of 3-year progression-free survival (PFS) was 93.1% in PET2– and 89.7% in PET2+ patients. Three-year overall survival was 98.6% and 94.4%, respectively. The estimated hazard ratio comparing PFS of patients with PET2+ and patients with PET2− was 1.03 (85% upper bound 2.38) and was significantly less than the null hypothesis of 4.1 (one-sided P = .04). CONCLUSION Our study of PET-adapted therapy in bulky stage I/II cHL met its primary goal and was associated with an excellent 3-year PFS rate of 92.3% in all patients, with the majority being spared radiotherapy and exposure to intensified chemotherapy.
Sex Differences in Phosphate Homeostasis: Females Excrete More Phosphate and Calcium After an Oral Phosphate Challenge
Authors: Turner Mandy E , Paynter Amanda S , White Christine A , Mazzetti Tom , Ward Emilie C , Norman Patrick A , Munroe Jenny , Adams Michael A , Holden Rachel M 
Published: October 2022

AbstractContextDietary consumption of phosphate is increasing, and elevated serum phosphate is associated with increased cardiovascular disease (CVD) risk. Sex differences in phosphate homeostasis and response to changes in dietary phosphate intake, which are not captured by clinically measured analytes, may contribute to differences in CVD presentation and bone disease.ObjectiveTo assess sex differences in acute phosphate homeostasis in response to a single oral phosphate challenge.DesignCross-sectional.SettingGeneral community.Participants78 participants (40-76 years) with measured glomerular filtration rate &gt;60 mL/min/1.73 m2 and no clinically diagnosed CVD and 14 young healthy adults.Main Outcome MeasuresTo elucidate subtle alterations in phosphate homeostasis, we employ an acute challenge whereby the hormonal response, circulating mineral levels, and urinary excretion are assessed following an oral challenge of phosphate.ResultsAlthough both males and females had similar changes in circulating phosphate, calcium, and parathyroid hormone in response to the challenge, females excreted ∼1.9x more phosphate and ∼2.7x more calcium than males, despite not consuming calcium. These sex differences were recapitulated in healthy young adults. This excretion response did not correlate to age, serum phosphate, or estradiol levels. The females with greater excretion of phosphate had higher levels of bone resorption markers compared to formation markers.ConclusionsTaken together, these data identify sex differences in acute phosphate homeostasis, specifically that females may mobilize and excrete endogenous sources of calcium and phosphate in response to oral phosphate compared to males. While high levels of dietary phosphate negatively impact bone, our results suggest that females may incur more risk from these diets.
Prevalence of COVID-19 and Risk Factors for Infection Among Pediatric Anesthesia Patients: A Report From the PEACOC Research Network
Authors: Kato Meredith A. , Zurakowski David , Adams AmandaMarie , Soelberg Julie , Staffa Steven J. , Bradford Victoria A. , Efune Proshad N. , Rodgers McCormick Megan E. , Grivoyannis Anastasia D. , Rossmann Beel Elizabeth , Correll Lynnie R. , Cheon Eric C. , Tan Gee Mei , Thomas James J. , Fernandez Allison M. , Teng Howard C. , Khanna Neha , Raman Vidya T. , Brzenski Alyssa B. , Frugoni Brian J. , Sheth Michelle M. , Rugnath Rahil M. , Meier Petra M. 
Published: October 2022

BACKGROUND:
The Pediatric Anesthesia COVID-19 Collaborative (PEACOC) is a research network to advance the care of children during the pandemic. Here we calculate the prevalence of coronavirus disease 2019 (COVID-19) among children undergoing anesthesia, look at prevalence in the population data from the Centers for Disease Control and Prevention (CDC), and assess independent risk factors for infection.

METHODS:
This was a multicenter, retrospective, observational study. Children aged 28 days to 18 years scheduled for anesthesia services at 12 centers requiring universal COVID-19 testing from March 29, 2020 to June 30, 2020 were included. COVID-19 positivity rates among those tested were plotted and trends were assessed using the Cochran Armitage test of trend. Independent risk factors were explored using multivariable logistic regression.

RESULTS:
Data were collected and analyzed on 33,320 anesthesia encounters including 265 children with COVID-19. Over the study period, the rates of infections in the pediatric anesthesia population did not demonstrate a significant trend. In the general population, there was a significant downward trend in infection rates (P < .001). In exploratory analysis, multivariable risk factors for a COVID-19 positive test were Black/African American race, Hispanic ethnicity, American Society of Anesthesiologists (ASA) physical status III or above, overweight and obese body mass index (BMI), orthopedic cases, abdominal cases, emergency cases, absence of injury and trauma, and West region (all P < .05).

CONCLUSIONS:
Rates of COVID-19 in pediatric anesthesia patients were consistently lower than in the general population. Independent risk factors of a positive test for children were identified. This is the first time universal testing for a single infectious disease was undertaken on a wide scale. As such, the association of infection with surgical case type or emergency case status is unprecedented.
Visitation
Authors: DeClue Jennifer 
Published: October 2022

In Visitation, Jennifer DeClue shows how Black feminist avant-garde filmmakers draw from historical archives in order to visualize and reckon with violence suffered by Black women in the United States. DeClue argues that these filmmakers—including Kara Walker, Kara Lynch, Tourmaline, and Ja’Tovia Gary—create spaces of mourning and reckoning rather than voyeurism and pornotropy. Through their use of editing, performance, and cinematic experimentation, these filmmakers intervene in the production of Blackness and activate new ways of seeing Black women and telling their stories. Theorizing these films as a form of conjure work, DeClue shows how these filmmakers raise the specters of Black women from the past and invite them to reveal history from their point of view. In so doing, Black feminist avant-garde filmmakers channel spirits that haunt archives and create cinematic arenas for witnessing Black women battling for survival during pivotal and exceedingly violent moments in US history.
Duke University Press Scholars of Color First Book Award recipient
The translation regulator Zar1l controls timing of meiosis in Xenopus oocytes
Authors: Heim Andreas , Niedermeier Marie L. , Stengel Florian , Mayer Thomas U. 
Published: October 2022

ABSTRACT
Oocyte maturation and early embryo development occur in vertebrates in the near absence of transcription. Thus, sexual reproduction of vertebrates critically depends on the timely translation of mRNAs already stockpiled in the oocyte. Yet how translational activation of specific mRNAs is temporally coordinated is still incompletely understood. Here, we elucidate the function of Zar1l, a yet uncharacterized member of the Zar RNA-binding protein family, in Xenopus oocytes. Employing TRIM-Away, we demonstrate that loss of Zar1l accelerates hormone-induced meiotic resumption of Xenopus oocytes due to premature accumulation of the M-phase-promoting kinase cMos. We show that Zar1l is a constituent of a large ribonucleoparticle containing the translation repressor 4E-T and the central polyadenylation regulator CPEB1, and that it binds directly to the cMos mRNA. Partial, hormone-induced degradation of Zar1l liberates 4E-T from CPEB1, which weakens translational repression of mRNAs encoding cMos and likely additional M-phase-promoting factors. Thus, our study provides fundamental insights into the mechanisms that ensure temporally regulated translation of key cell cycle regulators during oocyte maturation, which is essential for sexual reproductivity.
Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2
Authors: Shak Caroline , Vuolo Laura , Uddin Borhan , Katoh Yohei , Brown Tom , Mukhopadhyay Aakash G. , Heesom Kate , Roberts Anthony J. , Stevenson Nicola , Nakayama Kazuhisa , Stephens David J. 
Published: October 2022

ABSTRACT
The primary cilium is a sensory organelle, receiving signals from the external environment and relaying them into the cell. Mutations in proteins required for transport in the primary cilium result in ciliopathies, a group of genetic disorders that commonly lead to the malformation of organs such as the kidney, liver and eyes and skeletal dysplasias. The motor proteins dynein-2 and kinesin-2 mediate retrograde and anterograde transport, respectively, in the cilium. WDR34 (also known as DYNC2I2), a dynein-2 intermediate chain, is required for the maintenance of cilia function. Here, we investigated WDR34 mutations identified in Jeune syndrome, short-rib polydactyly syndrome and asphyxiating thoracic dysplasia patients. There is a poor correlation between genotype and phenotype in these cases, making diagnosis and treatment highly complex. We set out to define the biological impacts on cilia formation and function of WDR34 mutations by stably expressing the mutant proteins in WDR34-knockout cells. WDR34 mutations led to different spectrums of phenotypes. Quantitative proteomics demonstrated changes in dynein-2 assembly, whereas initiation and extension of the axoneme, localization of intraflagellar transport complex-B proteins, transition zone integrity and Hedgehog signalling were also affected.
Automated segmentation of endometriosis using transfer learning technique
Authors: Visalaxi S. , Sudalaimuthu T. 
Published: October 2022

Background: This paper focuses on segmenting the exact location of endometriosis using the state-of-art technique known as U-Net. Endometriosis is a progressive disorder that has a significant impact on women. The lesion-like appearance that grows inside the uterus and sheds for every periodical cycle is known as endometriosis. If the lesion exists and is transferred to other locations in the women’s reproductive system, it may lead to a serious problem. Besides radiologists deep learning techniques exist for recognizing the presence and aggravation of endometriosis. Methods: The proposed method known as structural similarity analysis of endometriosis (SSAE) identifies the similarity between pathologically identified and annotated images obtained from standardized dataset known as GLENDA v1.5 by implementing two systematic approaches. The first approach is based on semantic segmentation and the second approach uses statistical analysis. Semantic segmentation is a cutting-edge technology for identifying exact locations by performing pixel-level classification. In semantic segmentation, U-Net is a transfer-learning architecture that works effectively for biomedical image classification. The SSAE implements the U-Net architecture for segmenting endometriosis based on the region of occurrence. The second approach proves the similarity between pathologically identified images and the corresponding annotated images using a statistical evaluation. Statistical analysis was performed using calculation of both the mean and standard deviation of all four regions by implementing systematic sampling procedure. Results: The SSAE obtains the intersection over union value of 0.72 and the F1 score of 0.74 for the trained dataset. The means of both the laparoscopic and annotated images for all regions were similar. Consequently, the SSAE facilitated the presence of abnormalities in a specific region. Conclusions: The proposed SSAE approach identifies the affected region using U-Net architecture and systematic sampling procedure.
Surgical residents’ approach to training: are elements of deliberate practice observed?
Authors: Nelson Ferguson Kendra , Paradis Josée 
Published: October 2022

Background: Research in the area of deliberate practice has consistently shown that intense, concentrated, goal-oriented practice in a focused domain, such as medicine, can improve both skill development and performance to attain a progressively higher standard of excellence. In theory, utilizing deliberate practice in a medical context could result in improved surgical training and in turn better patient outcomes. Therefore, the purpose of this study was to gain a better understanding of how surgical residents approach their training from the perspective of the surgical residents themselves and to explore if elements of deliberate practice are observed. Methods: Eight surgical trainees participated in one of two focus groups depending on their training level (five junior residents; three senior residents). With the exploratory nature of this research, a focus group methodology was utilized. Results: By employing both deductive and inductive thematic analysis techniques, three themes were extracted from the data: learning resources and strategies, role of a junior/senior, and approaching weaknesses. Conclusions: Although elements of deliberate practice were discussed, higher functioning is necessary to achieve performance excellence, leading to improved patient outcomes.
The global trends and regional differences in incidence of Zika virus infection and implications for Zika virus infection prevention
Authors: Guo Zirui , Jing Wenzhan , Liu Jue , Liu Min 
Published: October 2022

Background
Zika virus (ZIKV) infection has potential result in severe birth effects. An improved understanding of global trend and regional differences is needed.

Methods
Annual ZIKV infection episodes and incidence rates were collected from Global Burden of Disease Study 2019. Episodes changes and estimated annual percentage changes (EAPCs) of age-standardized incidence rate (ASR) were calculated. Top passenger airport-pairs were obtained from the International Air Transport Association to understand places susceptible to imported ZIKV cases.

Results
Globally, the ASR increased by an average of 72.85% (95%CI: 16.47% to 156.53%) per year from 2011 to 2015 and subsequently decreased from 20.25 per 100,000 in 2015 to 3.44 per 100,000 in 2019. Most of ZIKV infections clustered in Latin America. The proportion of episodes in Central and Tropical Latin America decreased in 2019 with sporadic episodes elsewhere. High Socio-Demographic Index (SDI) regions had more episodes in 2019 than in 2015. Additionally, 15–49 years group had the largest proportion of episodes, females had a higher number of episodes, and a higher incidence rate of 70 plus group was observed in males than females. Certain cities in Europe, North America and Latin America/Caribbean had a high population mobility in ZIKV outbreak areas considered a high risk of imported cases.

Conclusions
ZIKV infection is still a public health threat in Latin America and Caribbean and high SDI regions suffered an increasing trend of ZIKV infection. Interventions such as development of surveillance networks and vector-control should be attached to ZIKV control in these key regions. Reproductive suggestions should be taken to reduce ZIKV-related birth defects for the people of reproductive age who are facing a higher threat of ZIKV infection, especially females. Moreover, surveillance of travellers is needed to reverse the uptrends of travel-related imported ZIKV infection. More studies focusing on ZIKV should be performed to make targeted and effective prevention strategies in the future.
Discussion of costs and financial burden in clinical practice: A survey of medical oncologists in Australia
Authors: Agarwal Anupriya , Karikios Deme J. , Stockler Martin R. , Morton Rachael L. 
Published: October 2022

Background
A diagnosis of cancer is associated with significant physical, psychological and financial burden. Including costs of cancer is an important component of shared decision making. Doctors bear a responsibility towards educating patients about the financial aspects of care. Multiple organisations have advocated for price transparency and implementing Informed Financial Consent in the clinic. However, few studies have evaluated the perspectives of oncologists on the current state of this discussion.

Aims
The aim of this study is to determine the views and perspectives of medical oncologists regarding communication of costs and financial burden in patients with cancer.

Methods
We conducted a prospective cross-sectional online survey via REDCap. The survey was distributed to medical oncologists and advanced trainees currently registered with Medical Oncology Group of Australia (MOGA). Data was collected using the online survey comprising socio-demographic characteristics, discussion of costs and financial burden, and facilitators and barriers to these discussions.

Results
547 members of MOGA were invited to participate in the study, and 106 of 547 MOGA members (19%) completed the survey. Most oncologists (66%) felt that it was their responsibility to discuss costs of care, however a majority of oncologists (59.3%) reported discussing costs with less than half of their patients. Only 25% of oncologists discussed financial concerns with more than half of their patients, and most oncologists were unfamiliar with cancer-related financial burden. Most Oncologists with greater clinical experience and those working in private practice were more likely to discuss costs with a majority of their patients.

Conclusions
Certain characteristics of medical oncologists and their practices were associated with reported prevalence of discussing costs of care and financial burden with their patients. In the context of rising costs of cancer care, interventions targeting modifiable factors such as raising oncologist awareness of costs of care and financial burden, screening for financial toxicity and availability of costs information in an easily accessible manner, may help increase the frequency of patient-doctor discussions about costs of care, contributing to informed decision-making and higher-quality cancer care.