bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review article: Clinical manifestations and outcomes of chronic nitrous oxide misuse: A systematic review
Authors: Marsden Pierce , Sharma Aakriti A , Rotella Joe‐Anthony 
Published: June 2022

AbstractRecreational nitrous oxide (N2O) use is widespread, and complications associated with its use are increasingly common. We sought to identify risk factors, clinical features and outcomes in individuals presenting with effects of chronic N2O abuse to develop an approach to clinical assessment and management. A systemic literature review was completed with searches conducted across EMBASE, MEDLINE, PSYCINFO and Cochrane databases. Our search strategy identified 612 studies, 105 met inclusion criteria, and 10 were added via hand search. Subjects from 24 case series and 91 case reports were typically in their 20s, using over 100 bulbs daily for several months. Neurological presentations, including sensory change, gait disturbance or weakness, were characteristic. Serum Vitamin B12 was normal or raised in 133 out of 243 case series subjects and 37 out of 84 reports. Serum homocysteine and methylmalonic acid were usually raised. Macrocytosis and anaemia were not commonly seen. MRI findings were abnormal with dorsal column change where specified, typically involving the cervical spine. Nerve conduction studies mostly reported a sensorimotor polyneuropathy. B12 replacement was the treatment of choice and partial recovery was most reported. This review highlights the dose‐dependent nature of chronic N2O toxicity and recognises functional B12 deficiency as the cause. As B12 is often normal, homocysteine and methylmalonic acid are important biomarkers of disease. An approach to diagnosis is offered but requires validation in prospective studies. Research exploring B12 and methionine therapy is required to refine management.
Distinct oxygen isotope fractionations driven by different electron donors during microbial nitrate reduction in lake sediments
Authors: Li Shengjie , Diao Muhe , Wang Shuo , Zhu Xianfang , Dong Xiaoli , Strous Marc , Ji Guodong 
Published: June 2022

AbstractMicrobial nitrate reduction can be driven by organic carbon oxidation, as well as by inorganic electron donors, such as reduced forms of sulfur and iron. An apparent inverse oxygen isotope fractionation effect was observed during nitrate reduction in sediment incubations from five sampling sites of a freshwater lake, Hongze Lake, China. Incubations with organic and inorganic electron donor additions were performed. Especially, the inverse oxygen isotope effect was intensified after glucose addition, whereas the incubations with sulfide and Fe2+ showed normal fractionation factors. Nitrate reductase encoding genes, napA and narG, were analysed with metagenomics. Higher napA/narG ratios were associated with higher oxygen fractionation factors. The most abundant clade (59%) of NapA in the incubation with glucose was affiliated with Rhodocyclales. In contrast, it only accounted for 8%–9% of NapA in the incubations with sulfide and Fe2+. Differences in nitrate reductases might explain different oxygen isotope effects. Our findings also suggested that large variance of O‐nitrate isotope fractionations might have to be considered in the interpretation of natural isotope records.
Efficacy evaluation of different measurement methods for target lesions after neoadjuvant chemotherapy and radical radiotherapy in locally advanced hypopharyngeal carcinoma
Authors: Hou Fang‐Jing , Zhao Dan , Yan Xin‐Yue , Li Xiao‐Ting , Sun Yan , Sun Ying‐Shi , Gao Shun‐Yu 
Published: June 2022

AbstractAimTo assess the diagnostic efficacy in response evaluation of hypopharyngeal carcinoma (HPC) using different CT measurement methods.Methods and materialsOne hundred and three patients with locally advanced HPC receiving neoadjuvant chemotherapy (NACT) and radical radiotherapy (RT) were retrospectively enrolled. The long diameter, short diameter and largest axial area of the tumors and the largest metastatic cervical lymph node (LN) were measured before and after NACT, at the end of RT and 1 month after RT. Tumor regression ratios of the sum of the tumor's long diameter and LN's short diameter (LDTSDL), the sum of tumor and LN's short diameter (TTSDL), the sum of tumor and LN's largest axial area (AATML) were calculated. Analysis was conducted for overall survival (OS), metastasis‐free survival, regional recurrence‐free survival (RRFS), and local recurrence‐free survival (LRFS).ResultsNote that 35, 28, 23, and 16 patients suffered death, local recurrence, regional recurrence and distant metastasis, respectively. TTSDL‐defined effective group demonstrated better LRFS (p = .039) and RRFS (p = .047) after NACT and better OS since the end of RT (p = .037); AATML‐defined effective groups demonstrated better OS, LRFS, and RRFS since the end of RT (p = .015, .008, and .005). While LDTSDL‐defined groups showed differences in OS and LRFS until 1 month after RT (p = .013 and .014).ConclusionsThe regression rate of TTSDL and AATML can distinguish prognosis at an earlier time and demonstrated better reliability compared with LDTSDL. They were recommended for response evaluation in HPC.
How does a protest last? Rituals of visibility, disappearances under custody, and the Saturday Mothers in Turkey
Authors: Can Başak 
Published: June 2022

AbstractOrganizing weekly silent sit‐in protests since the mid‐1990s, the families of the disappeared created Turkey's longest‐lasting civil disobedience movement, known as the Saturday Mothers. Ritualizing their resistance, the group maintained the feeling of solidarity among its participants, attracted spectators, and ensured public visibility. Yet, as this protest form became popular, the participants felt uncomfortable with how they were represented in the wider public, especially how they were reduced to the spectacle of suffering in official and popular discourses. Thus, they often found themselves grappling with the tension between their desire to become visible and their refusal to be represented as a public spectacle of mothers’ suffering. Rather than solely focusing on material and spiritual resources of the movement, activists’ meaning‐making processes, or the state's tactics to end the movement, this article introduces the analytics of ritual and spectacle to highlight the ongoing negotiations between protestors’ subjectivity, collective action, popular representations of the protest, and state violence. The productive tension between ritualized protest and its spectacularized lives suggests a need to revise anthropological theories about progressive social movements that juxtapose the hidden versus public, the individual versus collective, and the institutionalized versus spontaneous forms of resistance.
Mothers' regrets of having (or not having) returned to work after childbirth: Longitudinal relationships with organizational commitment
Authors: Wiese Bettina S. , Stertz Anna M. 
Published: June 2022

AbstractPostpartum mothers have to decide whether to leave the workforce for some time and, if so, when to return to paid work. Two kinds of regrets might evolve as a result of women's leave‐related decisions: stay‐at‐home and return‐to‐work regrets. The present research investigates how these forms of regrets are associated with women's affective organizational commitment. We conducted a four‐wave longitudinal study with female participants mostly living in Switzerland (61%) and Germany (37%). The first measurement occasion took place during pregnancy (N = 294), and the subsequent three postnatal measurement points were at 6 (n = 281), 12 (n = 254), and 24 months (n = 230) after childbirth. As expected, higher organizational commitment during pregnancy predicted stronger stay‐at‐home regrets. By contrast, women's prenatal organizational commitment did not turn out to be predictive for lowered return‐to‐work regrets. We further assumed cross‐lagged associations between post‐birth organizational commitment and return‐to‐work regrets. Our results suggest that return‐to‐work regrets are predictive of decreases in affective organizational commitment. Reversed causation, that is, effects from postnatal organizational commitment to return‐to‐work regrets, could not be confirmed. Results are discussed regarding theoretical, methodological, and practical implications.
Statin‐related adverse drug reactions in UK primary care consultations: A retrospective cohort study to evaluate the risk of cardiovascular events and all‐cause mortality
Authors: Insani Widya N. , Whittlesea Cate , Ju Chengsheng , Man Kenneth K. C. , Alwafi Hassan , Alsharif Alaa , Chapman Sarah , Wei Li 
Published: June 2022

AimsTo investigate the risk of cardiovascular disease (CVD) events and all‐cause mortality in patients with statin‐related adverse drug reaction (ADR) consultation in primary care and examine whether different treatments following the ADR affect subsequent outcomes.MethodsThis was a retrospective cohort study of statin users between 2004 and 2019 using IQVIA Medical Research Data (formally known as the THIN database). Patients with statin‐related ADR consultation were matched by propensity score (1:1) to statin users without ADR consultation based on demographics, comorbidities and concomitant medication. Cox proportional hazard regression was used to compare the risk of subsequent CVD event and all‐cause mortality, stratified by history of CVD. In the secondary analysis among patients with statin‐related ADR, treatment changes within a 1‐year period following the ADR were examined and the outcomes were compared between different treatment groups.ResultsAmong 1 564 687 statin users, 19 035 (1.22%) had a statin‐related ADR consultation in primary care. The mean (standard deviation) follow‐up time was 6.32 (3.74) years and 5.31 (3.83) years for CVD primary and secondary prevention cohorts, respectively. Statin‐related ADR consultation was associated with subsequent CVD events in both cohorts (adjusted hazard ratio [HR] of 1.39 [95% CI 1.23, 1.57] and 1.34 [95% CI 1.25,1.42], respectively). In the secondary analysis among patients with statin‐related ADR consultation, we found that (i) continued statin prescription or combination of any statin with additional lipid‐lowering treatment (LLT) and (ii) other LLT only were associated with lower risks of CVD event (adjusted HR 0.71 [95% CI 0.64, 0.78] and 0.75 [95% CI 0.62, 0.92], respectively) and all‐cause mortality (adjusted HR 0.46 [95% CI 0.42, 0.50] and 0.52 [95% CI, 0.43, 0.64], respectively), compared to discontinuation of all LLT.ConclusionStatin‐related ADR was associated with an increased risk of subsequent CVD event, indicating that these patients should be monitored more closely. Continued lipid‐lowering medication is of importance to protect against CVD events and mortality.
Impact of belantamab mafodotin‐induced ocular toxicity on outcomes of patients with advanced multiple myeloma
Authors: Abeykoon Jithma P. , Vaxman Julia , Patel Sanjay V. , Kumar Shaji , Malave Gabriella C. , Young Kimberly S. , Ailawadhi Sikander , Larsen Jeremy T. , Dispenzieri Angela , Muchtar Eli , Gonsalves Wilson I. , Kourelis Taxiarchis , Leung Nelson , Warsame Rahma , Go Ronald S. , Bergsagel Leif , Lacy Martha Q. , Rajkumar S. Vincent , Gertz Morie A. , Kapoor Prashant 
Published: June 2022

SummaryBelantamab mafodotin (BLMF) is a B‐cell maturation antigen‐directed antibody‐drug conjugate, recently approved for advanced multiple myeloma (MM). The impact of BLMF‐induced ocular toxicity on patient outcomes is unknown. We studied a cohort of 38 consecutively seen patients treated with BLMF outside of trials. Of those, 75% experienced ocular toxicity, with 69% developing keratopathy. Among patients requiring ocular toxicity‐related permanent BLMF discontinuation (14%) or dose reduction (11%), 70% had progression of MM within a median of 3 months (95% confidence interval: 0.2–not reached) following BLMF interruption or dose reduction. Ocular toxicity is a major deterrent to the continuous use of BLMF in routine clinical practice. Measures to successfully prevent and mitigate ocular toxicity should be developed to achieve the full potential of this agent.
Phonological similarity in the serial recall task hinders item recall, not just order
Authors: Roodenrys Steven , Guitard Dominic , Miller Leonie M. , Saint‐Aubin Jean , Barron Jeffrey M. 
Published: June 2022

AbstractThe phonological similarity effect in short‐term memory (STM) is the finding that serial recall of lists of similar sounding items is poorer than that of dissimilar sounding items. This is traditionally argued to be due to a detrimental effect on memory for the order of the words in the list and not on memory for the words themselves. Models that propose forgetting from STM is due to interference must invoke an additional compensatory process where the shared element of the words acts as a cue to recall, in order to account for the lack of an effect on memory for the words. However, the possibility of a detrimental effect of phonological similarity on item memory when these compensatory processes are not available has not been investigated. Two experiments (n = 60 and n = 57) in which similarity is operationalized in a way that precludes usage of compensatory processes are reported. The results clearly demonstrate that item recall is poorer for similar lists than dissimilar lists when similarity is defined in this way.
Prostatic arterial embolisation for men with benign prostatic hyperplasia: a Cochrane review
Authors: Jung Jae Hung , McCutcheon Karen Ann , Borofsky Michael , Young Shamar , Golzarian Jafar , Kim Myung Ha , Narayan Vikram , Dahm Philipp 
Published: June 2022

ObjectivesTo assess the effects of prostatic arterial embolisation (PAE) compared to other procedures for treatment of lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH).MethodsWe included randomised controlled trials (RCTs), as well as non‐randomised studies (NRSs) enrolling men with BPH undergoing PAE vs other surgical interventions via a comprehensive search up until 8 November 2021. Two independent reviewers screened the literature, extracted data, assessed risk of bias, performed statistical analyses by using a random‐effects model, and rated the certainty of evidence (CoE) of RCTs and NRSs.ResultsWe found data to inform two comparisons: PAE vs transurethral resection of prostate (TURP; six RCTs and two NRSs), and PAE vs sham (one RCT). This abstract focuses on the primary outcomes in a comparison of PAE vs TURP. Short‐term follow‐up: based on RCT evidence, there may be little to no difference in urological symptom score improvement (mean difference [MD] 1.72, 95% confidence interval [CI] −0.37 to 3.81; low CoE) and quality of life (QoL; MD 0.28, 95% CI −0.28 to 0.84; low CoE) measured by International Prostatic Symptom Score. We are very uncertain about the effects of PAE on major adverse events (risk ratio [RR] 0.75, 95% CI 0.19–2.97; very low CoE). Long‐term follow‐up: based on RCT evidence, PAE may result in little to no difference in urological symptom scores (MD 2.58, 95% CI −1.54 to 6.71; low CoE) and QoL (MD 0.50, 95% CI −0.03 to 1.04; low CoE). We are very uncertain about major adverse events (RR 0.91, 95% CI 0.20–4.05; very low CoE).ConclusionCompared to TURP, the impact on urological symptoms and QoL improvement as perceived by patients appears to be similar. This review did reveal major uncertainty as to how major adverse events compare.
Uretero‐enteric stricture outcomes: secondary analysis of a randomised controlled trial comparing open versus robot‐assisted radical cystectomy
Authors: Huang Chun , Assel Melissa , Beech Benjamin B. , Benfante Nicole E. , Sjoberg Daniel D. , Touijer Adam , Coleman Jonathan A. , Dalbagni Guido , Herr Harry W. , Donat Sherri Machele , Laudone Vincent P. , Vickers Andrew J. , Bochner Bernard H. , Goh Alvin C. 
Published: June 2022

ObjectivesTo analyse the risk of uretero‐enteric anastomotic stricture in patients randomised to open (ORC) or robot‐assisted radical cystectomy (RARC) with extracorporeal urinary diversion.Patients and MethodsWe included 118 patients randomised to RARC (n = 60) or ORC (n = 58) at a single, high‐volume institution from March 2010 to April 2013. Urinary diversion was performed by experienced open surgeons. Stricture was defined as non‐malignant obstruction on imaging, corroborated by clinical status, and requiring procedural intervention. The risk of stricture within 1 year was compared between groups using Fisher's exact test.ResultsIn all, 58 and 60 patients were randomised to RARC and ORC, respectively. We identified five strictures, all in the ORC group. In patients with ≥1 year of follow‐up, the increase in risk of stricture from open surgery was 9.3% (95% confidence interval 1.5%, 17%). Of the five strictures, three were managed endoscopically while two required open revision. There was no evidence that perioperative Grade 3–5 complications were associated with development of a stricture (P = 1) and no evidence of a difference in 24‐month estimated glomerular filtration rate between arms (P = 0.15).ConclusionsIn this study at a high‐volume centre, RARC with extracorporeal urinary diversion achieved excellent ureteric anastomotic outcomes. Purported increased risk of stricture is not a reason to avoid RARC. Future research should examine the impact of different surgical techniques and operator experience on the risk of stricture, especially as more intracorporeal diversions are performed.
Echoes of 1937: Recovering America's Wildlife Act would bring wildlife conservation funding full circle
Authors: Vaughan Branch J. , Karlen Jonathan , Organ John , Bishop Chad , Mitchell Michael , Regan Ronald , Millspaugh Joshua J. 
Published: June 2022

AbstractWildlife populations face significant threats, including habitat loss and climate change. However, the United States has faced major biodiversity crises in the past. In 1937, in response to dwindling wildlife populations, Congress passed the Federal Aid in Wildlife Restoration Act, known as “Pittman‐Robertson” (PR). The law helped restore wildlife populations by establishing a federal role in funding state wildlife agencies enabling states to develop the infrastructure and expertise for effective wildlife conservation. Now, the 117th Congress is considering the Recovering America's Wildlife Act (RAWA). RAWA would provide state, tribal, and territorial wildlife agencies the funding to implement their State Wildlife Action Plans for the conservation of nongame wildlife. Herein, we explore the relationship between PR and RAWA while tracing the historical roots of PR and discussing its successes and limitations. We also demonstrate how RAWA builds upon PR and could become a generational conservation accomplishment.
Circular RNA circ‐RCCD promotes cardiomyocyte differentiation in mouse embryo development via recruiting YY1 to the promoter of MyD88
Authors: Liu Yiwen , Gao Jianfang , Xu Min , Zhou Qianqian , Zhang Zhongxiao , Ye Jiaxin , Li Rui 
Published: June 2022

AbstractCongenital heart disease (CHD) is the most common birth defect, affecting approximately 1% of live births. Genetic and environmental factors are leading factors to CHD, but the mechanism of CHD pathogenesis remains unclear. Circular RNAs (circRNAs) are kinds of endogenous non‐coding RNAs (ncRNAs) involved in a variety of physiological and pathological processes, especially in heart diseases. In this study, three significant differently expressed circRNA between maternal embryonic day (E) E13 and E17 was found by microarray assay. Among them, the content of circ‐RCCD increases with the development of heart and was enriched in primary cardiomyocytes of different species, which arouses our attention. Functional experiments revealed that inhibition of circ‐RCCD dramatically suppressed the formation of beating cell clusters, the fluorescence intensity of cardiac differentiation marker MF20, and the expression of the myocardial‐specific markers CTnT, Mef2c, and GATA4. Next, we found that circ‐RCCD was involved in cardiomyocyte differentiation through negative regulation of MyD88 expression. Further experiments proved that circ‐RCCD inhibited MyD88 levels by recruiting YY1 to the promoter of MyD88; circ‐RCCD inhibited nuclear translocation of YY1. These results reported that circ‐RCCD promoted cardiomyocyte differentiation by recruiting YY1 to the promoter of MyD88. And, this study provided a potential role and molecular mechanism of circ‐RCCD as a target for the treatment of CHD.
Optimal multireservoir operation for flood control under constrained operational rules
Authors: Yang Zetai , Zheng Hao , Feng Suzhen , Chen Cheng , Wang Jinwen 
Published: June 2022

AbstractThis paper presents a multireservoir flood control model that incorporates operating rules to alleviate the risk that results from traditional flood control models. The model is accurately reformulated into one that can be solved with the mixed integer linear programming (MILP) and approximated with a two‐stage linear programming (TSLP) to speed up the solution by excluding all the binary variables. A scroll decision‐making strategy is proposed by assuming only a few days of future inflows being predicted with certainty. With 10 historical and 30 designed floods in different magnitudes, the models and methods are applied to the Yangtze River basin, which includes 11 cascade reservoirs. The results on average show the MILP reduces the rule violation by 17%, while the TSLP is more than 150 times faster in CPU time. Excluding one of the reservoirs from the simulation reveals that the Three Gorges (TG) contributes the most in flood detention, accounting for 76% on average for once‐in‐a‐century floods. Interestingly, with the scroll decision‐making strategy implemented, the change from 3 to 7 days of certain forecasting has the most significant reduction in both the rule violation and flood detention, indicating that the forecasting accuracy of more recent inflows is more valuable for flood control.
Autonomy in agrarian studies, politics, and movements: An inter‐paradigm debate
Authors: Vergara‐Camus Leandro , Jansen Kees 
Published: June 2022

AbstractAutonomy has been a term often used in agrarian studies to express the ability of individuals or collective subjects to escape the rule of capital or the control of the state. Academic interventions on autonomy in different fields and disciplines discuss how global capitalism operates and what kind of subjects, spaces, and practices can resist it and build alternatives to it. However, a closer look at the literature reveals contending notions of autonomy. This special issue therefore aims to stimulate theoretical debates on autonomy. This introduction provides an overview of the general problematic and major theoretical debates around which the discussion on autonomy has been taking place. This problematic is not specific to rural social subjects but involves the discussion within the Left about the need and possibility for radical social change. This article explores how ideas about autonomy are used by radical agrarian movements and critical agrarian studies scholars. It also presents the key issues covered by and the arguments of the different contributors to this special issue.