bluuebunny/crossref_metadata_2025_split huggingface dataset:
The BepiColombo Environment Radiation Monitor, BERM
Authors: Pinto Marco , Sanchez-Cano Beatriz , Moissl Richard , Benkhoff Johannes , Cardoso Carlota , Gonçalves Patrícia , Assis Pedro , Vainio Rami , Oleynik Philipp , Lehtolainen Arto , Grande Manuel , Marques Arlindo 
Published: September 2022

AbstractThe BepiColombo Environment Radiation Monitor (BERM) on board the European Space Agency’s Mercury Planetary Orbiter (MPO), is designed to measure the radiation environment encountered by BepiColombo. The instrument measures electrons with energies from $\sim150~\text{keV}$
∼
150

keV
to $\sim10~\text{MeV}$
∼
10

MeV
, protons with energies from $\sim1.5~\text{MeV}$
∼
1.5

MeV
to $\sim100~\text{MeV}$
∼
100

MeV
, and heavy ions with Linear Energy Transfer from 1 to $50~\text{MeV}\cdot\text{mg}^{-1}\cdot\text{cm}^{2}$
50

MeV
⋅

mg

−
1

⋅

cm
2

. BERM is operated continuously, being responsible for monitoring the radiation levels during all phases of the mission, including the cruise, the planetary flybys of Earth, Venus and Mercury, and the Hermean environment. In this paper, we describe the scientific objectives, instrument design and calibration, and the in-flight scientific performance of BERM. Moreover, we provide the first scientific results obtained by BERM during the BepiColombo flyby of Earth in April 2020, and after the impact of a solar energetic particle event during the cruise phase in May 2021. We also discuss the future plans of the instrument including synergies with other instruments on the BepiColombo and on other missions.
The Emerging Field of Psychedelic Psychotherapy
Authors: Barber Gregory S. , Aaronson Scott T. 
Published: September 2022

AbstractPurpose of ReviewFew treatments are available for patients with mood disorders or post-traumatic stress disorder (PTSD) who have already failed multiple interventions. After several decades when research into psychedelics was effectively halted by federal legislation, the past several years have shown the re-emergence of thoughtful investigations studying the utility of compounds such as 3,4-methylenedioxymethamphetamine (MDMA) and psilocybin.Recent FindingsSeveral studies have coupled the safe administration of psychedelic compounds in a controlled environment after several hours of preparation of study participants and followed by multiple sessions to integrate the psychedelic experience. The improvement participants experience appear related to the often profound perspective changes experienced and seem unlike the improvements seen in the currently available care paradigms. Studies cited include treatment resistant depression, end of life despair, and PTSD.SummaryPsychedelic psychotherapy, a unique remarriage of biological therapy and psychotherapy, has the potential to transform mental health care.
A new combination in Rockhausenia (Compositae: Senecioneae: Senecioninae)
Authors: Hind D. J. Nicholas 
Published: September 2022

SummaryThe recently described Werneria praetermissa (Compositae: Senecioneae: Senecioninae) from northwestern Argentina (Jujuy, Salta) and southern Bolivia (Tarija) is transferred to Rockhausenia.
Merkmale der Inanspruchnahmepopulation einer Eltern-Kind-Station: Frühe interaktionszentrierte Behandlung als Chance in der Kinder- und Jugendpsychiatrie
Authors: Taferner Christina , Jahnke-Majorkovits Ann-Christin , Nakamura Sanae , Sevecke Kathrin 
Published: September 2022

Zusammenfassung
Grundlagen
Bei einer stationären kinderpsychiatrischen Eltern-Kind Behandlung wird das Kind als Patient und die Eltern als Begleitperson aufgenommen, um der Bedeutung der Eltern-Kind-Interaktion bei der Entstehung und Aufrechterhaltung von psychischen Störungen von Kindern gerecht zu werden und Eltern in die Behandlung von Kindern mit emotionalen und/oder Verhaltensauffälligkeiten zentraler zu integrieren. Um diese Behandlungsform zukünftig weiter auszubauen und effektiver zu gestalten, wurden in der vorliegenden Studie die Merkmale der bisherigen Inanspruchnahmepopulation der kinderpsychiatrischen Eltern-Kind-Station in Tirol hinsichtlich der kindlichen Symptomatik mittels ICD-10 und DC:0–5 und der Belastung der Eltern genauer untersucht.

Methodik
Zur Überprüfung der kindlichen Symptomausprägung sowie der Belastung der Eltern wurden die Ergebnisse der Child Behavior Checklist 1 ½–5, der Child Behavior Checklist 6–18R sowie des Eltern-Belastungsinventars von Tröster (2011) von 96 Eltern-Kind-Paaren herangezogen.

Ergebnisse
Die 6–10-jährigen Patienten wiesen bei der Gesamtskala des CBCL höhere T‑Werte (M = 76,9, SD = 7,1) auf als die 0–5-jährigen Patienten (M = 63,1, SD = 12,4), t (50) = −3,52, p < 0,001. Bei der EBI-Gesamtskala unterschieden sich die 0–5-jährigen Patienten und die 6–10-jährigen Patienten hinsichtlich der T‑Werte nicht, t (54) = −0,75, p = 0,459, ebenso wie im EBI-Kinderbereich t (54) = −1,75, p = 0,087 und im EBI-Elternbereich, t (54) = 0,19, p = 0,846. Auch die vier Diagnosegruppen unterschieden sich weder in der Gesamtskala des EBI, F (4,58) = 1,34, p = 0,266, noch im Elternbereich des EBI, F (4,58) = 1,44, p = 0,232, oder im Kinderbereich des EBI, F (4,58) = 2,81, p = 0,033.

Schlussfolgerungen
Eine frühzeitige Erkennung und Behandlung von Verhaltensauffälligkeiten bzw. psychischen Störungen bei sehr jungen Kindern scheint maßgeblich, um langfristige negative Folgen sowie eine Chronifizierung zu verhindern. Eltern-Kind-Therapien sollten im Allgemeinen auf die Aufdeckung und Veränderung aktueller dysfunktionaler Interaktionsmuster zwischen Eltern und Kind fokussieren.
COVID-19 Serosurvey of Frontline Healthcare Workers in Western Australia
Authors: Ludewick Herbert , Hahn Rebecca , Italiano Claire , Pereira Lynette , Fatovich Daniel , Saxton Jemma , Hunt Richard , Ho Kwok M. , Boan Peter , Pavey Warren 
Published: September 2022

AbstractWe aimed to study COVID-19 infection in healthcare workers (HCWs) during the first wave in a setting of low community incidence prior to HCW vaccination. We performed a cross-sectional study of frontline HCWs in two tertiary hospitals in Western Australia with questionnaire and testing for SARS-CoV-2 IgG antibodies, using a screening assay followed by confirmatory assays for initial reactive results. 799 Frontline HCWs were enrolled in the study, working in the emergency department (n = 194, 24.2%), ICU (n = 176, 22.0%), respiratory ward (n = 20, 2.5%), COVID clinic (n = 37, 4.6%), and theatre (n = 222, 28%). 189 (23.6%) were doctors, 327 (41.0%) nurses, and 283 (35.4%) other. Contact with a known COVID-19-positive patient occurred at work for 337 (42.1%), and outside work for 10 (1.2%). Four were diagnosed with COVID-19 by PCR, acquired overseas in two cases and related to healthcare work in two cases (one acquired from a colleague and one possibly acquired from patient contact in the healthcare setting). Nine HCWs had reactive screening serology, and three had confirmed positive IgG (these three were PCR-positive cases). Infection control procedures in the setting of low community incidence were effective at preventing HCW acquisition of COVID-19 infection.
Facilitating Real-Time, Multidirectional Learning for Clinicians in a Low-Evidence Pandemic Response
Authors: Hunt Richard C , Braunstein Sofia P , Cuddy Egbert Lauren , Gorbach Katherine A , Rao Monisha , Pearson Jonathan D , Armistad Amy J , Arora Sanjeev , Bennett Celine A , Dezan Amanda M , Herrmann Jack , Redd John T , Jolly B. Tilman , Krohmer Jon R , Struminger Bruce B 
Published: September 2022

Abstract
As COVID-19 was declared a health emergency in March 2020, there was immense demand for information about the novel pathogen. This paper examines the clinician-reported impact of Project ECHO COVID-19 Clinical Rounds on clinician learning. Primary sources of study data were Continuing Medical Education (CME) Surveys for each session from the dates of March 24, 2020 to July 30, 2020 and impact surveys conducted in November 2020, which sought to understand participants’ overall assessment of sessions. Quantitative analyses included descriptive statistics and Mann-Whitney testing. Qualitative data were analyzed through inductive thematic analysis. Clinicians rated their knowledge after each session as significantly higher than before that session. 75.8% of clinicians reported they would ‘definitely’ or ‘probably’ use content gleaned from each attended session and clinicians reported specific clinical and operational changes made as a direct result of sessions. 94.6% of respondents reported that COVID-19 Clinical Rounds helped them provide better care to patients. 89% of respondents indicated they ‘strongly agree’ that they would join ECHO calls again.COVID-19 Clinical Rounds offers a promising model for the establishment of dynamic peer-to-peer tele-mentoring communities for low or no-notice response where scientifically tested or clinically verified practice evidence is limited.
Training of Medical Students for Mass Casualty Incidents Using Table-Top Gamification
Authors: Castro Delgado Rafael , Fernández García Lucía , Cernuda Martínez José Antonio , Cuartas Álvarez Tatiana , Arcos González Pedro 
Published: September 2022

Abstract

Introduction:
“Table-top” exercises can improve knowledge and skills related to mass casualty incidents (MCIs) with little logistical efforts. We aim to evaluate the learning process of 5th year medical school students related to MCI response using table-top simulation and measure their methodology perception.

Methods:
A theoretical part plus an MCI simulation board exercise was organized. Knowledge pretest and 1 mo after posttest was scored, and an assessment questionnaire with 27 questions with a Likert-type scale with 3 dimensions: methodology, knowledge acquisition, and skills acquisition was administered. Students did not receive any written or training material between pretest and posttest.

Results:
A total of 108 (80%) completed the evaluation questionnaire, pretest, and posttest. For the pretest, average grade was 4.25 (SD = 1.71) and 42% passed, and for the posttest, average grade was 8.33 (SD = 1.28) and 97 % pass (P < 0.0001). All variables measuring methodology perception scored more than 8, except for the duration of the exercise (7.3). Most knowledge acquisition scored above 9. Self-perception skill acquisition scores were slightly lower, although all above 7.

Conclusions:
“Table-top” methodology is useful for acquiring knowledge and skills related to MCI response. Retention of knowledge is very high. Students consider that this methodology can be very useful for medical studies. Active or nonactive role is a factor that only influences final results in specific items.
Topological dynamics of cosine maps
Authors: PARDO-SIMÓN LETICIA 
Published: September 2022

AbstractThe set of points that escape to infinity under iteration of a cosine map, that is, of the form
$C_{a,\,b} \colon z \mapsto ae^z+be^{-z}$
for
$a,\,b\in \mathbb{C}^\ast$
, consists of a collection of injective curves, called dynamic rays. If a critical value of
$C_{a,\,b}$
escapes to infinity, then some of its dynamic rays overlap pairwise and split at critical points. We consider a large subclass of cosine maps with escaping critical values, including the map
$z\mapsto \cosh(z)$
. We provide an explicit topological model for their dynamics on their Julia sets. We do so by first providing a model for the dynamics near infinity of any cosine map, and then modifying it to reflect the splitting of rays for functions of the subclass we study. As an application, we give an explicit combinatorial description of the overlap occurring between the dynamic rays of
$z\mapsto \cosh(z)$
, and conclude that no two of its dynamic rays land together.
RA33, an analogue of resveratrol, improves the development of in vitro-fertilized bovine embryos
Authors: Patrocinio Tais Aparecida , Fernandes Carlos Antônio de Carvalho , Macedo Gilson Costa , Silva Adilson David da , Barbosa Nadia Rezende Raposo , Quintao Carolina Capobiango Romano , Ribeiro Marcela Eduarda da Silva , Camargo Luiz Sergio Almeida 
Published: September 2022

SummaryOxidative stress is an undesirable effect of in vitro culture, which requires antioxidant supplementation. This study investigated the analogue of resveratrol (RA33) as an alternative to resveratrol, an antioxidant molecule, for the in vitro culture of in vitro-fertilized bovine embryos. The effect of different concentrations of RA33 on embryo development was evaluated and a comparison between RA33 and resveratrol was performed. The cleavage rate was higher (P < 0.05) with 2.5 μM (69.0 ± 4.4%) than at 0, 0.1 or 0.5 μM RA33 (62.1 ± 2.0%, 60.7 ± 5.9% and 56.7 ± 5.8%, respectively). The blastocyst rates on days 7 and 8 post-fertilization with 2.5 μM RA33 (19.4 ± 3.3% and 24.6 ± 3.3%, respectively) were higher (P < 0.05) than for 0 μM (12.4 ± 2.5% and 15.2±2.5%, respectively). When 2.5 μM RA33 was compared with 0.5 μM resveratrol, similar (P > 0.05) cleavage and blastocyst rates were found between them, but the cleavage rate was higher (P < 0.05) in the control (80.8 ± 3.4%) than for the resveratrol treatment (76.4 ± 3.6%). The numbers of apoptotic cells and the apoptotic index were lower (P < 0.05) with RA33 (6.5 ± 0.6 cells and 6.4 ± 0.7%, respectively) and resveratrol (5 ± 0.8 cells and 5.5 ± 1.0%, respectively) than in the control group (9.8 ± 1.2 cells and 8.9 ± 1.1%, respectively). In conclusion, RA33 can enhance the preimplantation development of in vitro-fertilized bovine embryos and be an alternative to resveratrol in embryo culture medium.
What do others think? The why, when and how of using surveys in CBT
Authors: Murray Hannah , Kerr Alice , Warnock-Parkes Emma , Wild Jennifer , Grey Nick , Clark David M. , Ehlers Anke 
Published: September 2022

Abstract
Surveys are a powerful technique in cognitive behavioural therapy (CBT). A form of behavioural experiment, surveys can be used to test beliefs, normalise symptoms and experiences, and generate compassionate perspectives. In this article, we discuss why and when to use surveys in CBT interventions for a range of psychological disorders. We also present a step-by-step guide to collaboratively designing surveys with patients, selecting the appropriate recipients, sending out surveys, discussing responses and using key learning as a part of therapy. In doing so, we hope to demonstrate that surveys are a flexible, impactful, time-efficient, individualised technique which can be readily and effectively integrated into CBT interventions.

Key learning aims
After reading this article, it is hoped that readers will be able to:

(1)
Conceptualise why surveys can be useful in cognitive behavioural therapy.

(2)
Implement collaborative and individualised survey design, delivery and feedback as part of a CBT intervention.
Seasonal Landslide Activity Lags Annual Precipitation Pattern in the Pacific Northwest
Authors: Luna L. V. , Korup O. 
Published: September 2022

AbstractSeasonal variations in landslide activity remain understudied compared to recent advances in landslide early warning at hourly to daily timescales. Here, we learn the seasonal pattern of monthly landslide activity in the Pacific Northwest from five heterogeneous landslide inventories with differing spatial and temporal coverage and reporting protocols combined in a Bayesian multi‐level model. We find that landslide activity is distinctly seasonal, with credible increases in landslide intensity, inter‐annual variability, and probability marking the onset of the landslide season in November. Peaks in landslide probability in January and intensity in February lag the annual peak in mean monthly precipitation and landslide activity is more variable in winter than in summer, when landslides are rare. For a given monthly rainfall, landslide intensity at the season peak in February is up to 10 times higher than at the onset in November, underlining the importance of antecedent seasonal hillslope conditions.
Moist Static Energy Transport Trends in Four Global Reanalyses: Are They Downgradient?
Authors: Clark Joseph P. , Feldstein Steven B. , Lee Sukyoung 
Published: September 2022

AbstractTrends in moist static energy (MSE) transport are investigated for the years 1980 through 2018 using four different reanalysis data sets. The reanalysis data sets show agreement in the eddy MSE transport trends and the latitudinal structure of the MSE trends, but vary widely in the trend of the flux of the climatological zonal mean MSE by the anomalous zonal mean meridional wind. The latter dominates the total MSE transport trends in all four data sets. Therefore, none of the four total MSE flux trends is downgradient of the corresponding MSE trend. Further analysis of the MSE trends reveals that dry static energy increases strongly dominate MSE trends at all latitudes, including in the tropics where climate models and theory predict latent energy increases to dominate. As changes in MSE transport are routinely assumed to be downgradient when interpreting changes in climate, including Arctic amplification, further investigation of reanalysis MSE transport is warranted.
Using Inverse Modeling and Dual Isotopes (δ15N and δ18O of NO3) to Determine Sources of Nitrogen Export From a Complex Land Use Catchment
Authors: Adiyanti Sri , Maruya Yasuyuki , Eyre Bradley D. , Mangion Perrine , Turner Jeffrey V. , Hipsey Mathew R. 
Published: September 2022

AbstractAttributing nitrogen export to specific land use within heterogeneous catchments remains a challenge due to the spatio‐temporal variability in conditions influencing the mobilization and fate of nitrogen species. This study demonstrates that the measurement of dual stable isotopes of nitrate, taken along with routine tributary measurement of nitrogen in nitrate (NO3−‐N) and ammonium (NH4+‐N), aids in apportioning sources of the overall nitrogen load during wet periods. An inverse modeling technique was developed to estimate the land use‐specific export rates of NO3−‐N and NH4+‐N from the Caboolture River Catchment in Queensland, Australia. Measurements of nitrogen in streamflow at 51 locations during six sampling campaigns (May 2012 to April 2013) were made along with catchment geospatial data that was used to disaggregate sub‐catchments into six land use fractions. A hydrological model was applied to compute the runoff from each fraction and water routing through the stream network. This data was used within a nitrogen mixing model with inclusion δ15NNO3 and δ18ONO3. The land uses specific export rate was computed inversely as the posterior of a Bayesian interference applied to the model. During higher rainfall periods when export rates were highest, the main land use exporting nitrogen was wetland (110 g/ha/day NO3−‐N, 27 g/ha/day NH4+‐N) resulted from mineralization and nitrification of organic N, followed by urban (16 g/ha/day NO3−‐N, 2.3 g/ha/day NH4+‐N). The advantage of using the dual isotopes in conjunction with the nitrogen concentration data was demonstrated by reduced uncertainty in the computed rates during the higher rainfall periods, relative to calculations without δ15NNO3 and δ18ONO3.
Gene set enrichment analysis of pathophysiological pathways highlights oxidative stress in psychosis
Authors: Pistis Giorgio , Vázquez-Bourgon Javier , Fournier Margot , Jenni Raoul , Cleusix Martine , Papiol Sergi , Smart Sophie E. , Pardiñas Antonio F. , Walters James T. R. , MacCabe James H. , Kutalik Zoltán , Conus Philippe , Crespo-Facorro Benedicto , Q Do Kim 
Published: September 2022

AbstractPolygenic risk prediction remains an important aim of genetic association studies. Currently, the predictive power of schizophrenia polygenic risk scores (PRSs) is not large enough to allow highly accurate discrimination between cases and controls and thus is not adequate for clinical integration. Since PRSs are rarely used to reveal biological functions or to validate candidate pathways, to fill this gap, we investigated whether their predictive ability could be improved by building genome-wide (GW-PRSs) and pathway-specific PRSs, using distance- or expression quantitative trait loci (eQTLs)- based mapping between genetic variants and genes. We focused on five pathways (glutamate, oxidative stress, GABA/interneurons, neuroimmune/neuroinflammation and myelin) which belong to a critical hub of schizophrenia pathophysiology, centred on redox dysregulation/oxidative stress. Analyses were first performed in the Lausanne Treatment and Early Intervention in Psychosis Program (TIPP) study (n = 340, cases/controls: 208/132), a sample of first-episode of psychosis patients and matched controls, and then validated in an independent study, the epidemiological and longitudinal intervention program of First-Episode Psychosis in Cantabria (PAFIP) (n = 352, 224/128). Our results highlighted two main findings. First, GW-PRSs for schizophrenia were significantly associated with early psychosis status. Second, oxidative stress was the only significantly associated pathway that showed an enrichment in both the TIPP (p = 0.03) and PAFIP samples (p = 0.002), and exclusively when gene-variant linking was done using eQTLs. The results suggest that the predictive accuracy of polygenic risk scores could be improved with the inclusion of information from functional annotations, and through a focus on specific pathways, emphasizing the need to build and study functionally informed risk scores.
Allopurinol and prostate cancer survival in a Finnish population-based cohort
Authors: Kukko Ville , Kaipia Antti , Talala Kirsi , Taari Kimmo , Tammela Teuvo L. J. , Auvinen Anssi , Murtola Teemu J. 
Published: September 2022

Abstract
Background
Allopurinol is gout medication that inhibits uric acid formation. Its possible anti-carcinogenic properties have been under research in past years. Studies based on Taiwanese registries showed that long term allopurinol use might reduce prostate cancer (PCa) incidence. However, our studies based on Finnish registries did not support those findings. In this study, we evaluate whether allopurinol use is associated with prostate cancer-specific survival (CSS) or overall survival (OS) in a Finnish population-based cohort.

Methods
The study cohort was originally enrolled for the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC). We included all newly diagnosed PCa cases during 1996–2015, 9252 men in total. Information on allopurinol purchases was from the national prescription registry of the Social Insurance Institution of Finland. Information about deaths, treatments, and use of other medications was obtained from registries, and tumor stage and PSA at diagnosis from medical records. Follow-up started at diagnosis, and we analysed separately two endpoints: PCa-specific death and overall death. We used an extended Cox regression with adjustment for age at diagnosis, Charlson comorbidity index, FinRSPC trial arm, use of other drugs and EAU PCa risk group.

Results
During a median follow-up of 9.86 years, 2942 deaths occurred, including 883 from PCa. There was no difference in CSS between allopurinol user and non-users, but allopurinol users had lower OS (multivariable-adjusted hazard ratio 1.77; 95% CI: 1.57–2.00). However, this decrease in OS was mitigated along with increasing intensity of allopurinol use.

Conclusions
We found no marked difference in CSS by allopurinol use. Allopurinol users had lower OS but there were no significant differences by duration or intensity of allopurinol use. Allopurinol use may not have anticancer effects against prostate cancer; instead, it may be a surrogate for metabolic problems causing shorter OS among men with PCa.