bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probabilistic constrained Bayesian inversion for transpiration cooling
Authors: Steins Ella , Bui‐Thanh Tan , Herty Michael , Müller Siegfried 
Published: August 2022

AbstractTo enable safe operations in applications such as rocket combustion chambers, the materials require cooling to avoid material damage. Here, transpiration cooling is a promising cooling technique. Numerous studies investigate possibilities to simulate and evaluate the complex cooling mechanism. One naturally arising question is the amount of coolant required to ensure a safe operation. To study this, we introduce an approach that determines the posterior probability distribution of the Reynolds number using an inverse problem and constraining the maximum temperature of the system under parameter uncertainties. Mathematically, this chance inequality constraint is dealt with by a generalized polynomial chaos expansion of the system. The posterior distribution will be evaluated by different Markov chain Monte Carlo based methods. A novel method for the constrained case is proposed and tested among others on two‐dimensional transpiration cooling models.
A novel fusion variant LSM14A::NR4A3 in extraskeletal myxoid chondrosarcoma
Authors: Ngo Carine , Verret Benjamin , Vibert Julien , Cotteret Sophie , Levy Antonin , Pechoux Cécile Le , Haddag‐Miliani Leila , Honore Charles , Faron Matthieu , Quinquis Fabien , Cesne Axel Le , Scoazec Jean‐Yves , Pierron Gaëlle 
Published: August 2022

AbstractExtraskeletal myxoid chondrosarcoma (EMC) is a rare soft tissue neoplasm of uncertain lineage characterized by the pathognomonic rearrangement of the NR4A3 gene, which in most cases is fused with EWSR1. Other NR4A3 fusion partners have been described, namely TAF15, FUS, TCF12, and TGF. Some studies suggest that EMCs with non‐EWSR1 variant fusion are associated with high‐grade morphology and worst clinical behavior compared to EWSR1::NR4A3 tumors, supporting the potential significance of particular fusion variant in EMC. We report a case of a 34‐year‐old male who presented with calf EMC and subsequently developed a slowly progressive metastatic disease 3 years after diagnosis. Whole‐transcriptome analysis with total RNA sequencing enabled identification of a novel fusion transcript LSM14A::NR4A3, expanding the molecular spectrum of EMC.
Leviathan as a financial godfather: Debt advantages of wholly state‐owned enterprises
Authors: Jara Mauricio , Musacchio Aldo , Wagner Rodrigo 
Published: August 2022

AbstractResearch SummaryWe examine the debt advantages of wholly owned state‐owned enterprises (WSOEs), due to an implicit sovereign insurance against default. Our model explains conditions that increase those advantages in bond yields. In our global sample of bonds, we find that bond issues of WSOEs, have a 57 bps discount in their yield to maturity vis‐à‐vis comparable corporations. The effect is even larger when we benchmark against partial state‐owned firms—an effect large enough to overcome the liability of foreignness. This cheaper debt finance is stronger during crises yet disappears for sovereigns with low creditworthiness. This lower cost of debt “inflates” the profits of the median WSOE by 13%.Managerial SummaryWe examine if wholly owned state‐owned enterprises (WSOEs) enjoy a lower cost of capital vis‐à‐vis their private counterparts when issuing bonds due to the perception that their debt is implicitly insured against default. We develop a model and undertake empirical tests to show that bond issues of WSOEs enjoy a 57 bps discount relative to private issues. This discount is large even relative to the premia companies pay when issuing bonds abroad. We also find that during crises the discount is larger as investors value the implicit insurance even more, but that it disappears for bond issues of governments with low creditworthiness. We estimate that for the median WSOE in our sample, the lower cost of capital inflates profits by 13%.
Lack of efficacy of convalescent plasma in COVID‐19 patients with concomitant hematological malignancies: An Italian retrospective study
Authors: Lanza Francesco , Monaco Federica , Ciceri Fabio , Cairoli Roberto , Sacchi Maria Vittoria , Guidetti Anna , Marchetti Monia , Massaia Massimo , Arcaini Luca , Krampera Mauro , Mohamed Sara , Gherlinzoni Filippo , Mecucci Cristina , Gentile Massimo , Romano Ilaria , Venditti Adriano , Ruggeri Marco , Ferrero Dario , Coviello Elisa , Fabbri Elisabetta , Corradini Paolo , Passamonti Francesco 
Published: August 2022

AbstractA multicenter retrospective study was designed to assess clinical outcome of COVID‐19 in patients with hematological malignancies (HM) following treatment with anti‐SARS‐CoV‐2 convalescent plasma (CP) or standard of care therapy. To this aim, a propensity score matching was used to assess the role of non‐randomized administration of CP in this high‐risk cohort of patients from the Italian Hematology Alliance on COVID‐19 (ITA‐HEMA‐COV) project, now including 2049 untreated control patients. We investigated 30‐ and 90‐day mortality, rate of admission to intensive care unit, proportion of patients requiring mechanical ventilatory support, hospitalization time, and SARS‐CoV‐2 clearance in 79 CP recipients and compared results with 158 propensity score‐matched controls. Results indicated a lack of efficacy of CP in the study group compared with the untreated group, thus confirming the negative results obtained from randomized studies in immunocompetent individuals with COVID‐19. In conclusion, this retrospective analysis did not meet the primary and secondary end points in any category of immunocompromized patients affected by HM.
Distribution of lymphoma subtypes in Ukraine according to the WHO 2016 classification
Authors: Kriachok Iryna , Stepanishyna Yana , Skrypets Tetiana , Shokun Nazar , Martynchyk Arina , Tytorenko Iryna , Aleksik Olena , Krotevych Mykhailo , Manni Martina , Federico Massimo 
Published: August 2022

AbstractThe Ukrainian Lymphoma Registry (ULR) was established in 2019 with the aim of monitoring the quality of diagnosis, staging, and treatment of lymphoma in Ukraine. Between September 2019 and October 2021, 546 patients with newly diagnosed lymphoma were prospectively registered. All cases were diagnosed according to the 2016 updated WHO lymphoma classification. The male‐to‐female ratio (M/F) for the whole population was 0.7, with a median age of 46 years (range 18–95). The adoption of the 2016 WHO classification resulted in the identification of 36 different lymphoma subtypes, with 132 cases (24.2%) classified differently compared to the 2008 WHO classification. Only 12 cases (2.8%) were true new entities, including seven cases of high‐grade B‐cell lymphoma NOS, three of anaplastic large B‐cell lymphoma, ALK‐negative, 1 case of HHV8+ DLBCL NOS, and 1 of high‐grade B‐cell lymphoma with C‐MYC and BCL2/BCL6 rearrangement. Moreover, 55 (61.1%) entities, including 37 defined by WHO 2008 and 18 defined by WHO 2016, were not represented at all. The analysis of cases registered in the ULR provides a comprehensive breakdown of the subtypes, stage distribution, and treatment of malignant lymphomas (ML) in Ukraine, supporting the usefulness of prospective data collection and timely reporting. We believe that this study is the first step toward a better understanding of the real‐life outcomes of patients with ML.
“When People Don't Know Me, They Think…”: Fostering a Multimodal Translanguaging Space that Leverages Students' Voices
Authors: Espinet Ivana , Chapman‐Santiago Charene 
Published: August 2022

AbstractThis article describes the design and implementation of a project from a translanguaging pedagogical stance. The research presented seeks to understand how translanguaging as a multimodal practice shapes the experiences of students in a traditional English Language Arts 8th‐grade classroom and how students leveraged their multimodal semiotic repertoires to explore identity expression. The article provides a framework for understanding translanguaging as a multimodal practice and discusses how it is embedded strategically in the design of instruction in a class in which many of the students are emergent bilinguals. It analyzes the process of producing short videos in which students critically examine how they were perceived by others and who they really are and presenting data that examine how students defy deficit perspectives and use their multimodal communicative repertoires to curate self‐representation.
Do biological activities of selective histone deacetylase 6 (HDAC6) inhibitors rely on the modification of cap group?
Authors: Liu Xingang , Wang Songsong , Shi Xiaoxing , Lu Ming , Wang Chengzhao , Li Xuedong , Zhang Yang , Jia Qingzhong , Liu Haisheng 
Published: August 2022

AbstractNowadays, significant progress has been made in the development of selective histone deacetylase 6 (HDAC6) inhibitors, exerting great potential in the treatment of various malignant tumors and neurodegenerative diseases. Previously, selective inhibitory activities of HDAC inhibitors were generally considered sensitive to the interactions between the Cap group and the binding site of HDAC6, and a large number of selective HDAC6 inhibitors have been designed and synthesized based on the strategy. However, some inhibitors without Cap group could also exhibit excellent potency and selective inhibition towards HDAC6, and in this study, BRD9757 and compound 8, as capless selective HDAC6 inhibitors, were selected as molecular probes to explore the difference of their binding interactions in HDAC1&6. Through the analysis of binding‐free energies and conformational rearrangements after 1 μs molecular dynamics simulation, it could be learned that although the residues in the binding site remained highly consistent, the binding mechanisms of BRD9757 and compound 8 in HDAC1&6 were different, which will provide valuable hints for the discovery of novel selective HDAC6 inhibitors.
Serosurvey in SARS‐CoV‐2 inactivated vaccine‐elicited neutralizing antibodies against authentic SARS‐CoV‐2 and its viral variants
Authors: Zou Lirong , Zhang Huan , Zheng Zhonghua , Jiang Yushan , Huang Yushi , Lin Shujian , Yu Jianxiang , Deng Xiaoling , He Jianfeng , Shen Chenguang , Li Baisheng 
Published: August 2022

AbstractVarious variants of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) have been emerging and circulating in different parts of the world. Millions of vaccine doses have been administered globally, which reduces the morbidity and mortality of coronavirus disease‐2019 efficiently. Here, we assess the immune responses of individuals after two shots of BBIBP‐CorV or CoronaVac inactivated vaccine. We measured neutralizing antibody responses after the second vaccination by using authentic SARS‐CoV‐2 and its viral variants. All the serum samples efficiently neutralized SARS‐CoV‐2 wild‐type lineage, in contrast, a part of serum samples failed to neutralize Alpha, Beta, Gamma, Delta, or Eta lineages, and only several serum samples were able to neutralize Omicron lineage virus strains (BA.1 and BA.2) with low neutralization titer. As compared with the neutralization of SARS‐CoV‐2 wild‐type lineage, the neutralization of all other SARS‐CoV‐2 variant lineages was significantly lower. Considering that all the SARS‐CoV‐2 mutation viruses challenged the antibody neutralization induced by BBIBP‐CorV and CoronaVac, it is necessary to carry out a third booster vaccination to increase the humoral immune response against the SARS‐CoV‐2 mutation viruses.
Incidence and impact of malnutrition in patients with Fontan physiology
Authors: Sekhon Ravneet , Foshaug Rae R. , Kantor Paul F. , Mansukhani Gitanjali , Mackie Andrew S. , Hollander Seth A. , Lewis Kylie , Conway Jennifer 
Published: August 2022

AbstractBackgroundSingle‐ventricle patients require a series of surgeries, with the final stage being the Fontan. This form of circulation results in several long‐term complications, but the impact and consequences of nutrition status remain unclear. We sought to evaluate the incidence of malnutrition in Fontan patients and the impact on outcomes.MethodsThis study was a retrospective cohort study of children who underwent Fontan surgery between 1997 and 2018. Clinical, demographic, and nutrition data were collected, including weight, height, body mass index (BMI), and their respective z scores (z score for weight‐for‐age [WAZ], z score for height‐for‐age [HAZ], and z score for BMI‐for‐age [BMIZ]) pre‐Fontan, at discharge, 6 months, and 1, 5, and 10 years post‐Fontan. Malnutrition status was categorized using the American Society for Parenteral and Enteral Nutrition guidelines and the Michigan MTool. Fontan failure was defined as listing for heart transplant or death.ResultsOf the 69 patients, moderate‐severe malnutrition occurred at any time point in 11% (n = 8) by WAZ, 16% (n = 11) by HAZ, and 6% (n = 4) by BMIZ. Moderate‐severe malnutrition persisted in 6.5%–12.9% at 10 years post‐Fontan. Compared with the pre‐Fontan period, there was no change in these parameters over time. There was no statistically significant difference in Fontan failure between degrees of pre‐Fontan malnutrition.ConclusionThere is a 6%–16% incidence of moderate‐severe malnutrition in Fontan patients. Malnutrition is a condition that remains present in follow‐up. There was no association with anthropometric parameters and transplant‐free survival. A prospective multi‐institutional study is needed to understand the impact of malnutrition on long‐term outcomes.
Using systems perspectives in evidence synthesis: A methodological mapping review
Authors: Hong Quan Nha , Bangpan Mukdarut , Stansfield Claire , Kneale Dylan , O'Mara‐Eves Alison , van Grootel Leonie , Thomas James 
Published: August 2022

AbstractReviewing complex interventions is challenging because they include many elements that can interact dynamically in a nonlinear manner. A systems perspective offers a way of thinking to help understand complex issues, but its application in evidence synthesis is not established. The aim of this project was to understand how and why systems perspectives have been applied in evidence synthesis. A methodological mapping review was conducted to identify papers using a systems perspective in evidence synthesis. A search was conducted in seven bibliographic databases and three search engines. A total of 101 papers (representing 98 reviews) met the eligibility criteria. Two categories of reviews were identified: (1) reviews using a “systems lens” to frame the topic, generate hypotheses, select studies, and guide the analysis and interpretation of findings (n = 76) and (2) reviews using systems methods to develop a systems model (n = 22). Several methods (e.g., systems dynamic modeling, soft systems approach) were identified, and they were used to identify, rank and select elements, analyze interactions, develop models, and forecast needs. The main reasons for using a systems perspective were to address complexity, view the problem as a whole, and understand the interrelationships between the elements. Several challenges for capturing the true nature and complexity of a problem were raised when performing these methods. This review is a useful starting point when designing evidence synthesis of complex interventions. It identifies different opportunities for applying a systems perspective in evidence synthesis, and highlights both commonplace and less familiar methods.
Network analysis of mild traumatic brain injury, persistent neurobehavioral and psychiatric symptoms, and functional disability among recent‐era United States veterans
Authors: Fonda Jennifer R. , Crowe Michael L. , Levin Laura K. , Jagger‐Rickels Audreyana , Marx Brian P. , Milberg William P. , McGlinchey Regina E. , Fortier Catherine B. 
Published: August 2022

AbstractRecent‐era U.S. veterans are clinically complex, with a high prevalence of co‐occurring mild traumatic brain injury (mTBI), psychiatric conditions, and behavioral dysfunction. The current study examined the direct and indirect associations between mTBI and persistent neurobehavioral, psychiatric, and functional disability symptoms among recent‐era U.S. veterans and service members (n = 648). We evaluated the postconcussive syndrome (PCS) potential causal model with two network analysis modeling approaches. Separate analyses were conducted for military mTBI and lifetime mTBI. An exploratory factor analysis was conducted to limit topological overlap in the network analysis. The most influential symptoms (i.e., the unique variables most strongly associated with the rest of the network) in the military mTBI network were behavioral disengagement, expected influence (EI) = 1.10; cognitive difficulties, EI = 1.08; agitation/irritability, EI = 1.05; and PTSD‐related reexperiencing and avoidance symptoms, EI = 0.98. After accounting for other symptoms, mTBI was only minimally informative, EI = 0.34. Additionally, military mTBI did not moderate the association between symptoms or the overall connectivity of the network. The results for lifetime mTBI were consistent with those for military mTBI. The present analyses identified a variety of behavioral, cognitive, and emotional symptoms that play an important role in understanding comorbidity and daily functioning among recent‐era U.S. veterans. Associations between cumulative mTBI that occurred in civilian or military settings were indirect and relatively small in magnitude. The current results add to a growing literature raising doubts about the PCS model.
A Validated 3D Printed Laryngeal Suturing Simulator for Endoscopic Laryngeal Cleft Repair
Authors: Richardson Clare M. , Zopf David A. , Ikeda Allison K. , van Horn Adam , Cohen Katheryn , Nourmohammadi Zahra , Nassar Michel , Park Jason S. , Johnson Kaalan E. 
Published: August 2022

ObjectivesEndoscopic laryngeal cleft repair (ELCR) with endolaryngeal suturing is an advanced surgical skill. This study objective was to assess the validity of 3‐dimensionally (3D) printed laryngeal suturing simulator for ELCR.Study DesignDevelopment and validation of a simulator for ELCR.MethodsAn ELCR model was developed using 3D printed and readily available materials. Participants were surveyed before and after a simulation session using five‐point Likert scale questions. Performance data was assessed using blinded expert video review and rated using a novel objective structured assessment of technical skills (OSATS) for endoscopic laryngeal suturing.ResultsTwenty‐one participants ranging from residents to attendings completed the simulation session. Survey respondents reported on a five‐point Likert scale that the model was “easy to use” and “quite realistic” (both mean of 4). Confidence improved significantly in 86% of participants (p < 0.01). Overall OSATS scores (out of a total of 55) showed a median improvement in technical skills of 11.7 points (p = 0.004). OSATS demonstrated good intra‐rater (κ = 0.689 and 0.677) and moderate inter‐rater (κ = 0.573) reliability. Completion times improved from the first to the last suture by a median time of 512 to 350 s (decrease of 202 s, p = 0.002). Participants with no prior ELCR experience improved more than those with in vivo experience.ConclusionThis study demonstrates the validity of a simulator utilizing 3D printed larynges for ELCR. A novel OSATS for endoscopic laryngeal suturing was successfully implemented. Confidence, technical skills, and completion times improved with the use of the model across a variety of participants. Laryngoscope, 133:785–791, 2023
Diagnostic value of CBCT in Chinese children with adenoid hypertrophy
Authors: Gao Dekun , Sun Xiayu , Yang Ying , Yang Jun , Cheng Lan 
Published: August 2022

AbstractObjectiveThe main objectives of the study were to investigate the reliability and accuracy of cone‐beam computed tomography (CBCT) in the diagnosis of adenoid hypertrophy in Chinese children and to evaluate its value in clinical diagnosis.MethodsFrom January 2019 to January 2020, 300 children with sleep snoring in Xinhua Hospital Affiliated to Medical College of Shanghai Jiaotong University were retrospectively studied. All patients underwent nasopharyngoscopy (NE) and CBCT scanning. The sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio of CBCT were determined according to the diagnostic criteria of NE, and the consistency between CBCT and NE was evaluated.ResultsThe clinical study of 300 children patients found that compared with NE, CBCT had a sensitivity of 87.3%, specificity of 89.2%, the positive predictive value of 93.20%, the negative predictive value of 80.5%, the positive likelihood ratio of 8.08, the negative likelihood ratio of 0.14, and Kappa value of .748.ConclusionCBCT is a reliable and accurate tool for the diagnosis of adenoid hypertrophy and can be used as an alternative examination method for children with contraindications or intolerance during NE.Level of Evidence4.
Simultaneously Toughening and Reinforcing Polylactide by Regulating the Distribution of Core–Shell Rubber Particles with Carbon Black
Authors: Liu Huili , Yan Yanan , Cai Jiaming , Bai Dongyu , Liu Song , Wang Jianchuan , Gao Guangyong 
Published: August 2022

AbstractStiffness–toughness balance is an important issue in rubber toughened polymer blends. In this work, a facile and effective route to simultaneously toughen and reinforce polylactide (PLA) by regulating the distribution of core–shell rubber (CSR) nanoparticles with carbon black (CB) is reported. The PLA/CSR/CB nanocomposites are prepared via direct melt‐blending PLA, CSR, and CB nanoparticles with different self‐aggregate capabilities. The FTIR and DFT calculation results reveal that the interactions between CB and CSR are stronger than those between CB and PLA. Thus, CB nanoparticles with high self‐aggregate capability (HCB) can drive CSR nanoparticles to join into the HCB network structures and form CSR‐HCB network structures in the PLA/CSR/HCB nanocomposites. However, for the CB nanoparticles with low self‐aggregate capability (LCB), uniform dispersion of both CSR nanoparticles and small‐sized CB clusters in the PLA/CSR/LCB nanocomposites is observed. Compared to the network structures, the uniform dispersion structure can endow PLA/CSR/CB nanocomposites with much better stiffness–toughness balance performances. Additionally, the distribution of CSR nanoparticles on the rheological properties of PLA/CSR/CB nanocomposites are studied. This work reveals significant correlations between distribution of CSR nanoparticles and properties of PLA nanocomposites, which is helpful to prepare high‐performance PLA materials.
High‐efficiency broadband rectifier with compact size for wireless power transfer
Authors: Long Hong‐Jun , Cheng Fei , Yu Sha , Gu Chao , Huang Kama 
Published: August 2022

AbstractIn this letter, an efficient broadband microwave rectifier with compact size for wireless power transfer is presented. It is proven that the proposed voltage doubler is easier to be matched than the series diode rectifier to achieve a wide bandwidth. In our analysis, the voltage doubler itself is already matched without the input matching network at the lower frequency band. For higher frequency band matching, a short section of microstrip line is connected to the input port of the voltage doubler. Thus, the proposed rectifier can operate over a broad bandwidth. To verify the design concept, a rectifier is fabricated, and the measurement results demonstrate that the power conversion efficiency is greater than 50% from 0.1 to 4.3 GHz at an 18 dBm input power level, and is higher than 70% within a wide bandwidth of 76.9%. In addition, when the input power is 18 dBm, the peak efficiency is 76.36% at 1.4 GHz. The results show that the proposed rectifier has the merits of compact size, broad bandwidth, and high efficiency.