bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiangiogenic Activity of Aerva lanata Flowers: In Vitro and In Vivo
Evaluation
Authors: D.V.R.N. Bhikshapathi , Ramdhan G  
Published: May 2022

Background:
A well-known traditional herb Aerva lanata is widely used in India for the management of different ailments including urolithiasis.

Objective:
In the current research, flowers of Aerva lanata were chosen for isolation of active constituents and screened for antiangiogenic and anticancer potentials, as literature supports those flowers have highest quantity of natural constituents when compared with the other parts of the plant.

Materials and methods:
Hydroalcoholic (80%-water, 20%-alcohol) extract of Aerva Lanata flowers was prepared. Antiangiogenic activity was screened by chick chorioallantoic membrane assay (CAM) (in vivo) and sponge implantation method (SIM) (in vivo). Anti-cancer potency was screened by cell migration (in vitro), tube formation assay (in vitro) and cell proliferation assay (in vitro).

Results:
The results of test groups were matched up to control group by applying one-way ANOVA, followed by a post hoc and Dunnett’s test. In CAM assay method significant branching points and angiogenic score was obtained at 10-5 M and 10-4 M. Considerable decline was observed in sponge weight, formation of blood vessels and hemoglobin content (Hb)at various concentrations of hydroalcoholic extract of Aerva Lanata flower (HAL) in SIM. The study on human umbilical vein endothelial cells displayed major inhibition of proliferation along with reduction in network length of cord-alike tubes in a dosage-dependent pattern.

Conclusions:
Aerva lanata has shown potent antiangiogenic and anticancer effect in a dose dependent manner.
Exploration of Curcumin against Various Biological Disorders: Mechanism
of Action and Pharmacotherapeutics
Authors: Malviya Rishabha , Kumar Mritunjay , Verma Swati , Sundram Sonali , Sharma Akanksha , Mishra Neelesh 
Published: May 2022

Abstract:
Synthetic drug usage has risen substantially, although plant-based medicines are more appropriate in terms of adverse effects. Through the classical era, humans relied on Phyto moieties to cure several illnesses, the most common of which is curcumin, the main phenol derived from the various varieties of turmeric. Its therapeutic and medicinal qualities are described in the Vedic Scriptures and Chinese medicine. Curcumin has been widely researched for its pleiotropic action, which includes anti-inflammatory, and antioxidant properties. The manuscript aims to describe the sources, properties, and pharmacological activities of curcumin. Turmeric is grown in entire India and curcumin is a major phytoconstituent of turmeric. It has pharmacological activities like antioxidant, analgesic, anticarcinogenic, chemo-preventive, anti-inflammatory, chemo-therapeutic, antifungal, antibacterial, antitumor, neuroprotective, antidiabetic, antiapoptotic, and immunomodulatory activities. Curcumin has been recommended in various research to have anticancer effects on several biochemical pathways associated with metastatic disease, cell cycle regulation, and so on. It can be concluded from the findings of the pieces of literature that curcumin is an important phytoconstituent and has the potential to treat various biological disorders. Curcumin’s anti-tumor efficacy is the most prominent research activity being carried by the researchers world-wide. In the present review, the authors have summarized the important pharmacological activities of curcumin and the mechanism of action involved to forecast the pharmacotherapeutic effect like for anticancer effect (suppression of NF-KB, intrinsic and extrinsic pathways, PKC inhibition and many more), for anti-viral effect (Interfering Genomic Replication, Inhibiting Virus attachment, Activation of cellular signaling Pathways, etc.), for Anti-diabetic (AMPK activation, Decreased liver fat deposition, etc.), for neuroprotective effect (Increased p-Akt and p-mToR levels, Reducing p-p338, LC-II/LC-I, p-38 levels, etc.) and for other activities also like antibacterial, immunomodulatory, anti-inflammatory and anti-oxidant.
A HPLC-UV Method for Analysis of Total Plant Extract and Catechin
Fraction of Bancha Green Tea
Authors: Stoeva Stanila , Radeva–Ilieva Maya , Zhelev Iliya , Georgiev Kaloyan 
Published: May 2022

Background:
The pharmacological characterization of Bancha green tea requires a preliminary establishment of its phytochemical composition.

Objective:
The aim of the present study was to develop a simple, sensitive, and environmentally friendly HPLC-UV procedure for the simultaneous quantification of caffeine, (+)-catechin, epigallocatechin gallate and gallic acid in different Bancha green tea isolates.

Methods:
The chromatographic separation of the four phytochemicals was performed on a Hypersil GOLD aQ column with a mobile phase consisting of acetonitrile/acetic acid/bi-distilled water (8:1:91 v/v/v), in an isocratic mode of elution. The suitability of the proposed procedure was verified by achieved satisfying linearity and specificity.

Results:
The method was also assessed as accurate and precise, with the obtained limits of quantification of caffeine, (+)-catechin, epigallocatechin gallate, and gallic acid of 0.01, 0.30, 0.50 and 0.03 μg/mL, respectively. As it was expected, the analytical procedure approbation showed the highest epigallocatechin gallate content (16.78 % ± 0.54) in the catechin fraction. On the other hand, the amount of caffeine and epigallocatechin gallate in the total plant extract was almost the same (4.19 % ± 0.14 and 4.12 % ± 0.44, respectively).

Conclusion:
A reliable HPLC-UV method for phytochemical characterisation of Bancha green tea extracts has been developed. The conducted quantitate assay could be used as a basis for subsequent pharmacological in vivo and in vitro studies of Bancha green tea.
Predicting the Next-Day Perceived and Physiological Stress of Pregnant Women by Using Machine Learning and Explainability: Algorithm Development and Validation
Authors: Ng Ada , Wei Boyang , Jain Jayalakshmi , Ward Erin A , Tandon S Darius , Moskowitz Judith T , Krogh-Jespersen Sheila , Wakschlag Lauren S , Alshurafa Nabil 
Published: May 2022

Background
Cognitive behavioral therapy–based interventions are effective in reducing prenatal stress, which can have severe adverse health effects on mothers and newborns if unaddressed. Predicting next-day physiological or perceived stress can help to inform and enable pre-emptive interventions for a likely physiologically and perceptibly stressful day. Machine learning models are useful tools that can be developed to predict next-day physiological and perceived stress by using data collected from the previous day. Such models can improve our understanding of the specific factors that predict physiological and perceived stress and allow researchers to develop systems that collect selected features for assessment in clinical trials to minimize the burden of data collection.

Objective
The aim of this study was to build and evaluate a machine-learned model that predicts next-day physiological and perceived stress by using sensor-based, ecological momentary assessment (EMA)–based, and intervention-based features and to explain the prediction results.

Methods
We enrolled pregnant women into a prospective proof-of-concept study and collected electrocardiography, EMA, and cognitive behavioral therapy intervention data over 12 weeks. We used the data to train and evaluate 6 machine learning models to predict next-day physiological and perceived stress. After selecting the best performing model, Shapley Additive Explanations were used to identify the feature importance and explainability of each feature.

Results
A total of 16 pregnant women enrolled in the study. Overall, 4157.18 hours of data were collected, and participants answered 2838 EMAs. After applying feature selection, 8 and 10 features were found to positively predict next-day physiological and perceived stress, respectively. A random forest classifier performed the best in predicting next-day physiological stress (F1 score of 0.84) and next-day perceived stress (F1 score of 0.74) by using all features. Although any subset of sensor-based, EMA-based, or intervention-based features could reliably predict next-day physiological stress, EMA-based features were necessary to predict next-day perceived stress. The analysis of explainability metrics showed that the prolonged duration of physiological stress was highly predictive of next-day physiological stress and that physiological stress and perceived stress were temporally divergent.

Conclusions
In this study, we were able to build interpretable machine learning models to predict next-day physiological and perceived stress, and we identified unique features that were highly predictive of next-day stress that can help to reduce the burden of data collection.
Subproducto de nanche (Byrsonima crassifolia): alternativa para la biosorción del cromo hexavalente
Authors: Sanchez-Silva Jonathan M. , González-Estrada Ramsés R. , Blancas-Benítez Francisco J. , Fonseca-Cantabrana Ángel 
Published: May 2022

En el presente estudio se investigó la biosorción del cromo hexavalente [Cr (VI)] utilizando un subproducto del nanche (Byrsonima crassifolia) en soluciones acuosas mediante el método batch, se evaluaron parámetros como el pH de la solución, concentración inicial del Cr (VI), dosis del adsorbente, tamaño de la partículay tiempo de contacto. Los resultados obtenidos demostraron que existe una mayor remoción del Cr (VI) con un pH ácido en la solución, utilizando un tamaño de partícula < 2.00 mm y aumentando la dosis del adsorbente en la biosorción batch, además se obtuvo una remoción total del Cr (VI) bajo los siguientes parámetros: 50 mg /L de Cr (VI), 1 g de adsorbente/30 mL, pH: 2.0, tamaño de la partícula entre 2.00–2.38 mm y un tiempo de contacto de una hora. A partir del ajuste de los modelos cinéticos se determinó que el modelo Pseudo-segundo orden describe mejor la cinética de la adsorción. En general, el subproducto del nanche puede considerarse un adsorbente con la capacidad de remover al Cr (VI) de soluciones acuosas.
Penerapan Model Pembelajaran Snowball Throwing Berbantuan Macromedia Flash dalam Meningkatkan Keterampilan Menulis Teks Eksposisi
Authors: Fitriasari Arindha 
Published: May 2022

Abstrak
Penelitian ini bertujuan untuk menguraikan peningkatan keterampilan menulis teks eksposisi peserta didik kelas VIII Ibnu Khaldun pada mata pelajaran Bahasa Indonesia dengan bantuan macromedia flash. Subjek penelitian yang dilaksanakan pada peserta didik kelas VIII Ibnu Khaldun SMP Islam Al Mujahidin Pamulang tahun ajaran 2020/2021. Desain penelitian yang digunakan oleh peneliti yaitu Penelitian Tindakan Kelas (PTK). Kegiatan penelitian ini diharapkan dapat meningkatkan keterampilan menulis teks eksposisi peserta didik. Prosedur tindakan dan implementasi tindakan terbagi ke dalam dua siklus. Siklus pertama, peneliti menggunakan model pembelajaran snowball throwing berbantuan macromedia flash dalam satu kali pertemuan. Siklus kedua, peneliti menggunakan desain yang sama dengan siklus pertama. Setiap siklus lebih mengutamakan pada struktur dan kaidah kebahasaan. Hasil penelitian ini menunjukkan adanya peningkatan keterampilan menulis teks eksposisi. Hal tersebut dapat dibuktikan pada hasil prasiklus, siklus I, dan siklus II. Prasiklus peserta didik mendapatkan nilai rata-rata 50,92. Siklus I peserta didik mendapatkan nilai rata-rata 71,67. Siklus II peserta didik mendapatkan nilai rata-rata 86,35. Hal tersebut dapat disimpulkan bahwa meningkatnya keterampilan menulis teks eksposisi model menggunakan model pembelajaran snowball throwing berbantuan macromedia flash
Kata kunci: Model snowball throwing, Teks Eksposisi, dan Macromedia Flash.
Using Economic Links between Firms to Detect Accounting Fraud
Authors: Li Chenchen , Li Ningzhong , Zhang Frank 
Published: May 2022

ABSTRACT
We explore whether accounting fraud can be detected using the information of firms economically linked to a focal firm. Specifically, we examine whether customer information disclosed by a supplier firm, combined with customers’ accounting information, helps to detect the supplier’s revenue fraud. We first confirm the economic link between the supplier and customers by showing a strong positive correlation between the supplier’s sales growth and the growth rate of total customer purchases. We then introduce two variables based on customer accounting information—the discrepancy between supplier sales growth and customer purchase growth and customer excess purchases—and show that they are predictive of supplier revenue fraud. We conduct a battery of cross-sectional tests and generally find results to vary cross-sectionally in a predictable way. Finally, the out-of-sample tests indicate that adding the two variables to Dechow, Ge, Larson, and Sloan (2011) model increases fraud prediction accuracy.
JEL Classifications: G14; M40; M41; M42.
Literasi Informasi Membantu Meningkatkan Kemampuan Informasi Dalam Proses Menyelesaikan Tugas Akhir Mahasiswa
Authors: Asnawati Asnawati 
Published: May 2022

Tujuan dari penelitian ini adalah untuk mendiskripsikan bagaimana pihak perpustakaan membantu mahasiswa menyelesaikan tugas akhir melalui layanan literasi informasi, perpustakaan mengembangkan berbagai macam layanan seperti melakukan bimbingan sumber refrensi, melakukan penulusuran informasi kompleks, melakukan bimbingan dalam bentuk literasi informasi dengan menyediakan sarana dalam menemukan informasi yang baik dan benar, melalui media online maupun offline. Literasi informasi merupakan kemampuan setiap orang untuk mendapatkan berbagai macam informasi yang digunakan untuk memecahkan masalah dan mengambil keputusan yang tepat sesuai dengan kebutuhan dalam menyelesaikan tugas akhir mahasiswa. Sehingga perpustakaan UIN Mataram menyediakan berbagai sumber informasi, baik secara printed maupun secara online yaitu dengan website yang dimilki oleh perpustakaan UIN Mataram. Penulis memakai pendekatan kualitatif dan teknik pengumpulan data menggunakan secara langsung ke informan. Upaya yang dilakukan pihak perpustakaan unuk membantu menyelesaikan tugas akhir mahasiswa ialah melalui Layanan Bookless library, melalui layanan e-jornal dan melalui layanan website perpustakaan UIN Mataram.
Perceived functions of allotment gardens and their importance during the COVID-19 pandemic in Poland
Authors: Janus Edyta , Szewczyk-Taranek Bożena , Smrokowska-Reichmann Agnieszka 
Published: May 2022

Abstract
This article describes the changes taking place in the functions of allotment gardens, their perceived value, reasons for purchasing allotments and subjective (self-reported) assessments of their importance during the pandemic. A questionnaire survey was conducted among 203 owners of allotment gardens located in three highly urbanised cities in the Silesian Voivodeship (Southern Poland). Semi-structured questionnaires and non-standardised questionnaires were used to collect the data. The results demonstrate that the respondents aged above 61 years (38.5%) have observed a generational change in the function of allotments, from cultivating fruits and vegetables to recreational purposes. Regardless of age, the owners of allotment gardens did not notice any technological progress or new crops. The young respondents (21–30 years) treated allotment gardens as an investment (36.7%), while the respondents aged below 20 years and over 61 years declared that the greatest benefits of allotment gardening are improved health and growing one’s own fruits and vegetables. The respondents aged over 41 years (25.9%) also pointed out the importance of growing their own produce. Allotments were especially important during the pandemic as a private space free from COVID-related restrictions. Extended interviews with the respondents revealed that allotment gardening was perceived as a coping strategy for the stress generated during the lockdown. This study showed that allotment gardens are important sites not only for food production but also for maintaining mental health, social capital and environmental engagement.
DETERMINANTS OF BUSINESS ETHICS DISCLOSURE IN INDONESIAN COMPANIES
Authors: Nugraheni Peni , Hastuti Fidiah Nur 
Published: May 2022

Etika bisnis dalam perusahaan diperlukan sebagai pedoman bagi perusahaan dalam menjalankan kegiatan operasionalnya. Penelitian ini bertujuan untuk menganalisis faktor-faktor yang mempengaruhi pengungkapan etika bisnis pada perusahaan yang bersaham syariah di Indonesia. Variabel independen terdiri dari ukuran dewan direksi, keragaman gender, kepemilikan institusional, kepemilikan manajerial, profitabilitas dan ukuran perusahaan. Dengan menggunakan content analysis, penelitian ini menguji 160 data dari perusahaan yang terdaftar dalam Daftar Efek Syariah (DES). Hasil penelitian menunjukkan bahwa kepemilikan manajerial dan ukuran perusahaan berpengaruh positif sedangkan sisanya tidak berpengaruh terhadap pengungkapan etika bisnis. Etika bisnis pada perusahaan syariah akan memperkuat identitas perusahaan yang selalu mengedepankan etika dalam aktivitas bisnisnya.

Business ethics in the company is needed as a guide for the company to carry out its operational activities. This study aims to analyze the factors the influence the disclosure of business ethics in Indonesian sharia compliant companies (SCC). The independent variables consist of board size, gender diversity, institutional ownership, managerial ownership, profitability and company size. Using content analysis, the study examines 160 data from companies listed in the Sharia Securities List (SSL). The results show that managerial ownership and company size have a positive effect while the rest have no effect on the disclosure of business ethics. Business ethics in sharia compliant companies will strengthen the identity of companies that always prioritize ethics in their business activities.
EFEKTIVITAS PENGGUNAAN E-BUPOT 23/26
Authors: Karina Mahda , H Simanjuntak Dr. Binsar 
Published: May 2022

This study aims to analyze the influence of the variables of quality system and user satisfaction on the effectiveness of use e-Bupot 23/26 with taxation understanding as a moderating variable by testing hypotheses that have been formulated previously. This type of research is descriptive with a quantitative approach. This study uses primary data with distributed questionnaire to corporate taxpayers who are registered with Tax Office of Central Jakarta and the sample were 69 respondents using convenience sampling. The analytical method used is Multiple Regression with statistic tools SPSS. The results of this study indicate that quality system have a positive effect and user satisfaction not have a positive effect on the effectiveness of use e-Bupot 23/26. The taxation understanding can not strengthen positive effect quality system and user satisfaction on the effectiveness of use e-Bupot 23/26.

Penelitian ini bertujuan untuk menganalisis pengaruh variable kualitas sistem dan kepuasan pengguna terhadap efektivitas penggunaan e-Bupot 23/26 dengan pemahaman perpajakan sebagai variabel moderasi dengan melalui pengujian hipotesis yang telah dirumuskan sebelumnya. Jenis penelitian ini deskriptif dengan pendekatan kuantitatif. Penelitian ini menggunakan data primer yaitu menyebarkan kuesioner kepada wajib pajak badan yang terdaftar di KPP Madya Jakarta Pusat dan sample sebanyak 69 responden dengan cara convenience sampling. Metode analisis yang digunakan adalah Regresi Berganda dengan alat uji software SPSS. Hasil penelitian ini menunjukkan bahwa kualitas sistem berpengaruh positif dan kepuasan pengguna tidak berpengaruh positif terhadap efektivitas penggunaan e-Bupot 23/26. Untuk pemahaman perpajakan tidak dapat memperkuat pengaruh positif kualitas system dan kepuasan pengguna terhadap efektfitas penggunaan e-Bupot 23/26.
KOMPETENSI, MORALITAS DAN SISTEM WHISTLEBLOWING DALAM PENCEGAHAN FRAUD: STUDI EMPIRIS PADA ORGANISASI PEMERINTAHAN INDONESIA
Authors: CHAIRI NURUL , INDRIANI MIRNA , DARWANIS DARWANIS 
Published: May 2022

This study aims to investigate whether apparatus competence, whistleblowing system, and morality play a role in influencing fraud prevention. It is also intended to prove whether whistleblowing system has a mediating effect on the relationship among apparatus competence, morality and fraud prevention. The research subjects comprise of civil servants of Government Institutions of Central/Provinces/Regencies/Cities in Indonesia. The hypotheses were tested on 201 respondents who were selected using convenience sampling method. The data were collected using survey questionnaires sent via online using Google Form from January to February 2021. The data were analyzed using Structural Equation Modeling - Partial Least Square (SEM-PLS).
The results of this study showed that whistleblowing system and morality influenced fraud prevention. Nevertheless, it appeared that apparatus competence did not influence fraud prevention. This study also proves that whistleblowing system has a mediating effect on the relationship among apparatus competence, morality and fraud prevention.

Penelitian ini bertujuan untuk mengetahui pengaruh kompetensi aparatur, sistem whistleblowing, dan moralitas terhadap pencegahan fraud dengan peran mediasi sistem whistleblowing. Responden penelitian terdiri 201 Aparatur Sipil Negara (ASN) pada pemerintahan Pusat/Provinsi/Kabupaten/Kota di Indonesia. Pengumpulan data dilakukan dengan menggunakan kuesioner Google Form yang disebarkan secara online. Data dianalisis dengan menggunakan SEM-PLS (Structural Equation Modeling - Partial Least Square).
Hasil penelitian menunjukkan bahwa sistem whistleblowing dan moralitas berpengaruh terhadap pencegahan fraud sedangkan kompetensi aparatur tidak memiliki pengaruh terhadap pencegahan fraud. Hasil pengujian juga menyatakan bahwa sistem whistleblowing memiliki efek mediasi terhadap masing-masing hubungan antara kompetensi aparatur dan moralitas dengan pencegahan fraud. Implikasi penelitian ini dapat dijadikan dasar pada kebijakan manajerial terhadap sistem whistleblowing yang perlu dikembangkan dalam organisasi.
Influence of printing procedure and printing axis of dental alloys on dimensional accuracy, surface roughness, and porosity
Authors: Graf Simon , Berger Moritz , Rohr Nadja 
Published: May 2022

Objectives:
This study aimed to evaluate the printing procedure and printing axis and its influence on the dimensional accuracy, surface roughness, porosity, and strength of 3D-printed dental alloys used in orthodontics prepared using binder jetting (BJ), electron beam melting (EBM), or selective laser melting (SLM).

Material and Methods:
Specimens with a dimension of 50 mm × 12 mm were produced using BJ, EBM, and SLM techniques of dental alloys and were printed either along the X-, Y-, or Z-axis (n = 8 per group). Specimen dimension was chosen according to the ISO standard 6892-1 for tensile strength test specimens. Surface roughness parameters Sa, Sz, Sq, and Ssk were obtained using a 3D laser microscope and porosities were visualized with scanning electron microscopy (SEM). The specimen surfaces were optically scanned and volumetric deviations from the original stereolithography files were calculated. Afterward, tensile strength was measured.

Results:
The printing method and printing axis significantly affected surface roughness parameters (P < 0.05). Overall, the lowest surface roughness Sa values were found for BJ (9.1 ± 3.4 µm) followed by SLM (39.8 ± 24.2 µm) and EBM (50.4 ± 6.4 µm). BJ showed the smallest dimensional deviation followed by EBM and SLM. SEM analysis revealed a porous structure of BJ while fewer pores were observed on EBM and SLM samples. The ultimate tensile strength was only determined for BJ (495 ± 6 MPa) and EBM (726 ± 50 MPa) as the strength of SLM superseded the strength of the holder of the universal testing machine.

Conclusion:
BJ printing provides the highest dimensional accuracy with the smoothest surfaces irrespective of the printing axis. However, the remaining porosities owed to this printing procedure may have decreased the strength of the material.