bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic modeling of predictive maintenance with survival analysis for mobile work equipment
Authors: Yang Zhen , Kanniainen Juho , Krogerus Tomi , Emmert-Streib Frank 
Published: May 2022

AbstractIn recent years there is a data surge of industrial and business data. This posses opportunities and challenges at the same time because the wealth of information is usually buried in complex and frequently disconnected data sets. Predictive maintenance utilizes such data for developing prognostic and diagnostic models that allow the optimization of the life cycle of machine components. In this paper, we address the modeling of the prognostics of machine components from mobile work equipment. Specifically, we are estimating survival curves and hazard rates using parametric and non-parametric models to characterize time dependent failure probabilities of machine components. As a result, we find the presence of different types of censoring masking the presence of different populations that can cause severe problems for statistical estimators and the interpretations of results. Furthermore, we show that the obtained hazard functions for different machine components are complex and versatile and are best modeled via non-parametric estimators. However, notable exceptions for individual machine components can be found amenable for a Generalized-gamma and Weibull model.
Design of highly perceptible dual-resonance all-dielectric metasurface colorimetric sensor via deep neural networks
Authors: Son Hyunwoo , Kim Sun-Je , Hong Jongwoo , Sung Jangwoon , Lee Byoungho 
Published: May 2022

AbstractColorimetric sensing, which provides effective detection of bio-molecular signals with one’s naked eye, is an exceptionally promising sensing technique in that it enables convenient detection and simplification of entire sensing system. Though colorimetric sensors based on all-dielectric nanostructures have potential to exhibit distinct color variations enabling manageable detection due to their trivial intrinsic loss, there is crucial limitation that the sensitivity to environmental changes lags behind their plasmonic counterparts because of relatively small region of near field-analyte interaction of the dielectric Mie-type resonator. To overcome this challenge, we proposed all-dielectric metasurface colorimetric sensor which exhibits dual-resonance in the visible region. Thereafter, we confirmed with simulation that, in the elaborately designed dual-Lorentzian-type spectra, highly perceptible variations of structural color were manifested even in minute change of peripheral refractive index. In addition to verifying physical effectiveness of the superior colorimetric sensing performance appearing in the dual-resonance type sensor, by combining advanced optimization technique utilizing deep neural networks, we attempted to maximize sensing performance while obtaining dramatic improvement of design efficiency. Through well-trained deep neural network that accurately simulates the input target spectrum, we numerically verified that designed colorimetric sensor shows a remarkable sensing resolution distinguishable up to change of refractive index of 0.0086.
Initial TK-deficient HSV-1 infection in the lip alters contralateral lip challenge immune dynamics
Authors: Rousseau Antoine , Haigh Oscar , Legrand Roger , Palgen Jean-Louis , Lemaitre Julien , Deback Claire , Oziol Noémie , Lomonte Patrick , Labetoulle Marc 
Published: May 2022

AbstractPrimary infection with herpes simplex type 1 (HSV-1) occurring around the mouth and nose switches rapidly to lifelong latent infection in sensitive trigeminal ganglia (TG) neurons. Sporadic reactivation of these latent reservoirs later in life is the cause of acute infections of the corneal epithelium, which can cause potentially blinding herpes simplex keratitis (HSK). There is no effective vaccine to protect against HSK, and antiviral drugs provide only partial protection against recurrences. We previously engendered an acute disease-free, non-reactivating latent state in mice when challenged with virulent HSV-1 in orofacial mucosa, by priming with non-neurovirulent HSV-1 (TKdel) before the challenge. Herein, we define the local immune infiltration and inflammatory chemokine production changes after virulent HSV-1 challenge, which were elicited by TKdelprime. Heightened immunosurveillance before virulent challenge, and early enhanced lymphocyte-enriched infiltration of the challenged lip were induced, which corresponded to attenuation of inflammation in the TG and enhanced viral control. Furthermore, classical latent-phase T cell persistence around latent HSV-1 reservoirs were severely reduced. These findings identify the immune processes that are likely to be responsible for establishing non-reactivating latent HSV-1 reservoirs. Stopping reactivation is essential for development of efficient vaccine strategies against HSV-1.
ILDR1 promotes influenza A virus replication through binding to PLSCR1
Authors: Liu Yueyue , Lin Shuqian , Xie Yunhui , Zhao Lu , Du Haibo , Yang Shifa , Yin Bin , Li Guiming , Zhao Zengcheng , Huang Zhongli , Xu Zhigang , Wu Jiaqiang 
Published: May 2022

AbstractAs a natural antiviral regulator, phospholipid scramblase 1 (PLSCR1) has been shown to inhibit influenza virus replication in infected cells through interacting with NP of influenza A virus (IAV). But its antiviral function as well as the underlying regulatory mechanism has not been examined in vivo. In the present work, we show that PLSCR1 expression is decreased in H1N1 SIV-infected mice, and Plscr1−/− mice are more susceptible to H1N1 SIV infection. By performing yeast two-hybrid screening, we identified immunoglobulin-like domain-containing receptor 1 (ILDR1) as a novel PLSCR1-binding partner. ILDR1 is highly expressed in the lungs, and its expression level is increased after virus infection. Interestingly, ILDR1 could not directly interact with virus NP protein, but could combine with PLSCR1 competitively. Our data indicates that there is a previously unidentified PLSCR1-ILDR1-NP regulatory pathway playing a vital role in limiting IAV infection, which provides novel insights into IAV-host interactions.
Oocyte aneuploidy rates in river and swamp buffalo types (Bubalus bubalis) determined by Multi-color Fluorescence In Situ Hybridization (M-FISH)
Authors: Pauciullo Alfredo , Versace Carmine , Perucatti Angela , Gaspa Giustino , Li Ling-Yu , Yang Chun-Yan , Zheng Hai-Ying , Liu Qinyou , Shang Jiang-Hua 
Published: May 2022

AbstractAneuploidy is one of the main causes of fetal and embryonic mortality in mammals. Nonetheless, its incidence in domestic ruminants has been investigated little. Indeed, no incidence data have ever been reported for water buffalo. To establish the incidence of aneuploidy in this species, we analysed in vitro matured metaphase II (MII) oocytes with corresponding first polar bodies (I PB) of the river (2n = 50) and swamp (2n = 48) buffaloes. For the first time, six river type probes (corresponding to chromosomes 1–5 and heterosome X), were tested on swamp buffalo metaphases using Multicolor-Fluorescent In Situ Hybridization (M-FISH) before their use on oocytes MII metaphases. Of the 120 total Cumulus Oocyte Complexes (COCs, 60 for each buffalo type) subjected to in vitro maturation, 104 reached the MII stage and were analysed by M-FISH. Haploid chromosome arrangement and visible I PB were observed in 89 of the oocytes (45 in river and 44 in swamp type). In the river type, the analysis revealed one oocyte was disomic for the chromosome X (2.22%). In the swamp type, one oocyte was found to be nullisomic for chromosome X (2.27%); another was found to be nullisomic for chromosome 5 (2.27%). We also observed one oocyte affected by a premature separation of sister chromatids (PSSC) on the chromosome X (2.27%). In both buffalo types, no abnormalities were detected in other investigated chromosomes. Based on merged data, the overall aneuploidy rate for the species was 3.37%. Oocytes with unreduced chromosomes averaged 1.92% across the two types, with 1.96% in river and 1.88% in swamp. The interspecies comparison between these data and cattle and pig published data revealed substantial difference in both total aneuploidy and diploidy rates. Reducing the negative impact of the meiotic segregation errors on the fertility is key to more sustainable breeding, an efficient embryo transfer industry and ex-situ bio-conservation. In this respect, additional M-FISH studies are needed on oocytes of domestic species using larger sets of probes and/or applying next generation sequencing technologies.
Quantum annealing algorithms for Boolean tensor networks
Authors: Pelofske Elijah , Hahn Georg , O’Malley Daniel , Djidjev Hristo N. , Alexandrov Boian S. 
Published: May 2022

AbstractQuantum annealers manufactured by D-Wave Systems, Inc., are computational devices capable of finding high-quality heuristic solutions of NP-hard problems. In this contribution, we explore the potential and effectiveness of such quantum annealers for computing Boolean tensor networks. Tensors offer a natural way to model high-dimensional data commonplace in many scientific fields, and representing a binary tensor as a Boolean tensor network is the task of expressing a tensor containing categorical (i.e.,$$\{0, 1\}$${0,1}) values as a product of low dimensional binary tensors. A Boolean tensor network is computed by Boolean tensor decomposition, and it is usually not exact. The aim of such decomposition is to minimize the given distance measure between the high-dimensional input tensor and the product of lower-dimensional (usually three-dimensional) tensors and matrices representing the tensor network. In this paper, we introduce and analyze three general algorithms for Boolean tensor networks: Tucker, Tensor Train, and Hierarchical Tucker networks. The computation of a Boolean tensor network is reduced to a sequence of Boolean matrix factorizations, which we show can be expressed as a quadratic unconstrained binary optimization problem suitable for solving on a quantum annealer. By using a novel method we introduce called parallel quantum annealing, we demonstrate that Boolean tensor’s with up to millions of elements can be decomposed efficiently using a DWave 2000Q quantum annealer.
Targeting undruggable carbohydrate recognition sites through focused fragment library design
Authors: Shanina Elena , Kuhaudomlarp Sakonwan , Siebs Eike , Fuchsberger Felix F. , Denis Maxime , da Silva Figueiredo Celestino Gomes Priscila , Clausen Mads H. , Seeberger Peter H. , Rognan Didier , Titz Alexander , Imberty Anne , Rademacher Christoph 
Published: May 2022

AbstractCarbohydrate-protein interactions are key for cell-cell and host-pathogen recognition and thus, emerged as viable therapeutic targets. However, their hydrophilic nature poses major limitations to the conventional development of drug-like inhibitors. To address this shortcoming, four fragment libraries were screened to identify metal-binding pharmacophores (MBPs) as novel scaffolds for inhibition of Ca2+-dependent carbohydrate-protein interactions. Here, we show the effect of MBPs on the clinically relevant lectins DC-SIGN, Langerin, LecA and LecB. Detailed structural and biochemical investigations revealed the specificity of MBPs for different Ca2+-dependent lectins. Exploring the structure-activity relationships of several fragments uncovered the functional groups in the MBPs suitable for modification to further improve lectin binding and selectivity. Selected inhibitors bound efficiently to DC-SIGN-expressing cells. Altogether, the discovery of MBPs as a promising class of Ca2+-dependent lectin inhibitors creates a foundation for fragment-based ligand design for future drug discovery campaigns.
A tri‐band complementary frequency selective surface with very closely spaced resonances
Authors: Sátiro da Silva Bruno , Pereira de Siqueira Campos Antonio Luiz , Tavares Sousa Matheus Emanuel , Neto Alfredo Gomes , Dionísio de Andrade Humberto 
Published: May 2022

AbstractThis paper presents a tri‐band complementary frequency selective surface (CFSS) with very closely spaced bands and angular stability. The proposed CFSS element geometry is composed of double concentric rings. The choice of this geometry is because of its very good angular stability. The gap between resonance frequencies is very close, only 404 MHz from the first to second band and 202 MHz from the third to second, which is only possible because of the use of CFSS. The CFSS simulation is performed using HFSS software and the design used the equivalent circuit method. The simulated results are compared with the experimental ones for validation purposes. A very good agreement is observed between the simulated and measured results.
And then they were two: Detection of non-thermal radio emission from the bow shocks of two runaway stars
Authors: Moutzouri M. , Mackey J. , Carrasco-González C. , Gong Y. , Brose R. , Zargaryan D. , Toalá J. A. , Menten K. M. , Gvaramadze V. V. , Rugel M. R. 
Published: May 2022

Context. In recent years, winds from massive stars have been considered promising sites for investigating relativistic particle acceleration. In particular, the resulting bow-shaped shocks from the interaction of the supersonic winds of runaway stars with interstellar matter have been intensively observed at many different wavelengths, from radio to γ-rays.
Aims. In this study we investigate the O4If star, BD+43° 3654, the bow shock of which is, so far, the only one proven to radiate both thermal and non-thermal emission at radio frequencies. In addition, we consider NGC 7635, the Bubble Nebula, as a bow shock candidate and examine its apex for indications of thermal and non-thermal radio emission.
Methods. We observed both bow shocks in radio frequencies with the Very Large Array (VLA) in the C and X bands (4–8 GHz and 8–12 GHz) and with the Effelsberg telescope at 4–8 GHz. We analysed single-dish and interferometric results individually, in addition to their combined emission, obtained spectral index maps for each source, and calculated their spectral energy distributions. Results. We find that both sources emit non-thermal emission in the radio regime, with the clearest evidence for NGC 7635, whose radio emission has a strongly negative spectral index along the northern rim of the bubble. We present the first high-resolution maps of radio emission from NGC 7635, finding that the morphology closely follows the optical nebular emission. Our results are less conclusive for the bow shock of BD+43° 3654, as its emission becomes weaker and faint at higher frequencies in VLA data. Effelsberg data show a much larger emitting region (albeit a region of thermal emission) than is detected with the VLA for this source.
Conclusions. Our results extend the previous radio results from the BD+43° 3654 bow shock to higher frequencies, and with our NGC 7635 results we double the number of bow shocks around O stars with detected non-thermal emission, from one to two. Modelling of the multi-wavelength data for both sources shows that accelerated electrons at the wind termination shock are a plausible source for the non-thermal radio emission, but energetics arguments suggest that any non-thermal X-ray and γ-ray emission could be significantly below existing upper limits. Enhanced synchrotron emission from compressed galactic cosmic rays in the radiative bow shock could also explain the radio emission from the BD+43° 3654 bow shock, but not from NGC 7635. The non-detection of point-like radio emission from BD+43° 3654 puts an upper limit on the mass-loss rate of the star that is lower than values quoted in the literature.
Occurrence rate and duration of space weather impacts on high-frequency radio communication used by aviation
Authors: Fiori Robyn A. D. , Kumar Vickal V. , Boteler David H. , Terkildsen Michael B. 
Published: May 2022

High frequency (HF) radio wave propagation is sensitive to space weather-induced ionospheric disturbances that result from enhanced photoionization and energetic particle precipitation. Recognizing the potential risk to HF radio communication systems used by the aviation industry, as well as potential impacts on GNSS navigation and the risk of elevated radiation levels, the International Civil Aviation Organization (ICAO) initiated the development of a space weather advisory service. For HF systems, this service specifically identifies shortwave fadeout, auroral absorption, polar cap absorption, and post-storm maximum useable frequency depression (PSD) as phenomena impacting HF radio communication and specifies moderate and severe event thresholds to describe event severity. This paper examines the occurrence rate and duration of events crossing the moderate and severe thresholds. Shortwave fadeout was evaluated based on thresholds in the solar X-ray flux. Analysis of 40-years of solar X-ray flux data showed that moderate and severe level solar X-ray flares were observed, on average, 123 and 5 times per 11-year solar cycle, respectively. The mean event duration was 68 min for moderate level events and 132 min for severe level events. Auroral absorption events crossed the moderate threshold for 40 events per solar cycle, with a mean event duration of 5.1 h. The severe threshold was crossed for 3 events per solar cycle with a mean event duration of 12 h. Polar cap absorption had the longest mean duration at ~8 h for moderate events and 1.6 days for severe events; on average, 24 moderate and 13 severe events were observed per solar cycle. Moderate and severe thresholds for shortwave fadeout, auroral absorption, and polar cap absorption were used to determine the expected impacts on HF radio communication. Results for polar cap absorption and shortwave fadeout were consistent with each other, but the expected impact for auroral absorption was shown to be 2–3 times higher. Analysis of 22 years of ionosonde data showed moderate, and severe PSD events occurred, on average, 200 and 56 times per 11-year solar cycle, respectively. The mean event duration was 5.5 h for moderate-level events and 8.5 h for severe-level events. During solar cycles 22 and 23, HF radio communication was expected to experience moderate or severe impacts due to the ionospheric disturbances caused by space weather, a maximum of 163 and 78 days per year, respectively, due to the combined effect of absorption and PSD. The distribution of events is highly non-uniform with respect to the solar cycle: 70% of moderate or severe events were observed during solar maximum compared to solar minimum.
Enhancement of high-frequency performances by Al2O3 interlayer in FeCoHf/Al2O3/FeCoHf trilayers
Authors: Jing Zhao-Xuan , Zhang Shou-Heng , Li Shandong 
Published: May 2022

In this study, Hf-doped FeCo alloy films with a high ferromagnetic resonance (FMR) frequency at zero external fields were prepared by a composition gradient sputtering method. In order to further enhance the high-frequency performances, Al2O3 spacers of various thicknesses were inserted in the middle of the FeCoHf film. It is revealed that the Al2O3 interlayer improves the magnetic anisotropy of trilayers, enhances the resistivity, and refines the grain size. As a result, the FMR frequency of the trilayer was enhanced to over 3 GHz, and the permeability was also evidently improved from 41 (single layer) to 86 (trilayer with Al2O3 thickness of 40 Å).
Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction
Authors: Elayyan Jinan , Carmon Idan , Zecharyahu Lital , Batshon George , Maatuf Yonathan H. , Reich Eli , Dumont Maitena , Kandel Leonid , Klutstein Michael , Dvir-Ginzberg Mona 
Published: May 2022

SignificanceCartilage mineralization is imperative in various processes such as skeletal growth and fracture repair. However, this process may also be pathological, as in the case of the degenerative joint disease, osteoarthritis (OA). Using a posttraumatic OA model (PTOA), we find that cartilage-specificSirt1genetic nulls caused severe synovitis and mineralization of the lateral joint compartment, due to augmentedLef1gene expression. Conversely, cartilage-specificLef1nulls exhibited impaired synovitis and mineralization of the lateral joint, accompanied by a reduction of local pain. Consistently, transcriptomic profiles ofLef1-ablated chondrocytes exhibited enhanced anabolism, yet impaired pathways related to calcification and inflammation. Accordingly, cartilage mineralization of the lateral joint compartment relies on amplified inflammatory pathways, contributing to articular damage following PTOA.
A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli
Authors: van Elzelingen Wouter , Goedhoop Jessica , Warnaar Pascal , Denys Damiaan , Arbab Tara , Willuhn Ingo 
Published: May 2022

Significance
Although it is undisputed that striatal dopamine plays a prominent role in motivated behavior and learning, the precise information conveyed by dopamine signals as such is under active debate. For a long time, the idea dominated that dopamine encodes a reward prediction error and that this signal is broadcast uniformly throughout the brain. However, here, we capture dopamine dynamics across many striatal regions and demonstrate that dopamine release is, regionally, extremely heterogeneous and that a reward prediction error–like signal is predominantly found in the relatively small limbic domain of the striatum. Another striking organizing principle is that stimulus valence directs dopamine concentration homogeneously across all regions (i.e., appetitive stimuli increase dopamine and aversive stimuli decrease dopamine).
Electrical responses from human retinal cone pathways associate with a common genetic polymorphism implicated in myopia
Authors: Jiang Xiaofan , Xu Zihe , Soorma Talha , Tariq Ambreen , Bhatti Taha , Baneke Alexander J. , Pontikos Nikolas , Leo Shaun M. , Webster Andrew R. , Williams Katie M. , Hammond Christopher J. , Hysi Pirro G. , Mahroo Omar A. 
Published: May 2022

Significance
Myopia prevalence has increased dramatically over recent decades. Genome-wide association studies have identified numerous loci, but mechanisms by which genotypic identity confers myopia susceptibility are unknown. The common variant most strongly associated with myopia is near a gene encoding retinal gap junctions. We analyzed retinal electrophysiological responses from 186 twins genotyped at this locus, finding association between cone-driven, but not rod-driven, electroretinogram signals and allelic genotype. Examination of responses to further, nonstandard testing protocols, together with recordings from patients with selective loss of bipolar cell signals, points to an effect on cone-driven hyperpolarizing (“OFF”) signals. The pattern of retinal expression of this gene appears consistent with these findings, which support a potential role for altered cone-driven signaling in myopia development.
Degrees of non-standardness
Authors: Vuković Teodora , Escher Anastasia , Sonnenhauser Barbara 
Published: May 2022

AbstractA corpus-based method for assessing a range of dialect-standard variation is presented for identifying samples exhibiting the highest prevalence of dialect features. This method provides insight into areal and inter-speaker variation and allows the extraction of maximally non-standard manifestations of the dialect, which may then be sampled and used for the study of language change and variation. The focus is on a non-standard Torlak variety, which has undergone considerable change under the influence of standard Serbian. The degree of variation is assessed by measuring the frequencies of five distinguishing linguistic features: accent position, dative reflexivesi, auxiliary omission in the compound perfect, the post-positive article, and analytic case marking in the indirect object and possessive. Locations subject to the greatest and least influence of the standard are revealed using hierarchical clustering. A positive correlation between the frequencies of occurrence reveals which non-standard feature is the best predictor of the others.