bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidental discovery of a Hodgkin lymphoma synchronous to a papillary thyroid carcinoma
Authors: Ben Thayer Maissa , Khanchel Fatma , Helal Imen , Chiboub Dorra , Ben Lazreg Khouloud , Hedhli Raweh , Ben Brahim Ehsen , Jouini Raja , Cheddli‐Debbich Aschraf 
Published: August 2022

AbstractPapillary thyroid carcinoma is the most common type of thyroid cancer and accounts for almost 89.4% of all thyroid carcinomas. Hodgkin lymphoma is a heterogeneous group of neoplasms and represents 10% of lymphomas. These two cancers do not share the same risk factors. Some studies have reported the association of thyroid papillary carcinoma with lymphomas, mainly Hodgkin's lymphoma, treated with radiotherapy. However, to our knowledge less than 10 cases have illustrated synchronous papillary thyroid carcinoma and Hodgkin lymphoma with no history of radiotherapy. We present the case of a 49‐year‐old female patient, with no history of past exposure to radiation, who was incidentally diagnosed with Hodgkin lymphoma during the work up for papillary thyroid carcinoma. Our patient had total thyroïdectomy with cervical lymphadenectomy. The histopathologic examination concluded to a papillary thyroid carcinoma of classical variant. And the lymph node dissection enabled us to diagnose not only papillary thyroid carcinoma's lymph node metastasis, but also Hodgkin Lymphoma. This discovery of the Hodgkin lymphoma was totally incidental. The discovery of synchronous tumors in patients with papillary thyroid carcinoma has been reported in the literature. However, the diagnosis of Hodgkin through lymph node dissection for papillary thyroid carcinoma is extremely rare. This underlines the singularity and the importance of our case. The synchronous papillary thyroid carcinoma and Hodgkin lymphoma is a rare condition, which may pose significant diagnostic and treatment dilemmas. To date, there is no standardized approach due to lack of experience. The molecular mechanisms of this link are poorly understood and yet remain to be elucidated.
Mixed‐methods evaluation of a nurse‐led allergy clinic model in primary care: Feasibility trial
Authors: Hammersley Vicky , Kelman Margaret , Morrice Lynn , Kendall Marilyn , Mukerjhee Mome , Harley Susan , Schwarze Jurgen , Sheikh Aziz 
Published: August 2022

AbstractIntroductionIt is now widely acknowledged that there are serious shortcomings in allergy care provision for patients seen in primary care. We sought to assess the feasibility of delivering and evaluating a new nurse‐led allergy service in primary care, measured by recruitment, retention and estimates of the potential impact of the intervention on disease‐specific quality of life.MethodsMixed‐methods evaluation of a nurse‐led primary care‐based allergy clinic in Edinburgh, UK undertaken during the period 2017–2021 with a focus on suspected food allergy and atopic eczema in young children, allergic rhinitis in children and young people, and suspected anaphylaxis in adults. Prior to March 2020, patients were seen face‐to‐face (Phase 1). Due to COVID‐19 pandemic restrictions, recruitment was halted between March–August 2020, and a remote clinic was restarted in September 2020 (Phase 2). Disease‐specific quality of life was measured at baseline and 6–12 weeks post intervention using validated instruments. Quantitative data were descriptively analysed. We undertook interviews with 16 carers/patients and nine healthcare professionals, which were thematically analysed.ResultsDuring Phase 1, 426/506 (84%) referred patients met the eligibility criteria; 40/46 (87%) of Phase 2 referrals were eligible. Males and females were recruited in approximately equal numbers. The majority (83%) of referrals were for possible food allergy or anaphylaxis. Complete data were available for 338/426 (79%) patients seen in Phase 1 and 30/40 (75%) in Phase 2. Compared with baseline assessments, there were improvements in disease‐specific quality of life for most categories of patients. Patients/carers and healthcare professionals reported high levels of satisfaction, this being reinforced by the qualitative interviews in which convenience and speed of access to expert opinion, the quality of the consultation, and patient/care empowerment were particularly emphasised.ConclusionThis large feasibility trial has demonstrated that it is possible to recruit, deliver and retain individuals into a nurse‐led allergy clinic with both face‐to‐face and remote consultations. Our data indicate that the intervention was considered acceptable to patients/carers and healthcare professionals. The before‐after data of disease‐specific quality of life suggest that the intervention may prove effective, but this now needs to be confirmed through a formal randomised controlled trial.Trial RegistrationClinicalTrials.gov reference NCT03826953.
Evaluation of anticancer effects of frankincense on breast cancer stem‐like cells
Authors: Farahani Mohammad Kamalabadi , Bitaraf Fateme Sadat , Atashi Amir , Jabbarpour Zahra 
Published: August 2022

AbstractBackgroundRelapse and metastasis in breast cancer are linked to cancer stem cells (CSCs) resistant to anticancer therapies. The presence of cancer stem‐like cells (CSLCs) and their ability to self‐renew is determined by in vitro spheroid formation.AimsMany studies have found that frankincense has anticancer impacts, although these effects on breast CSLCs have never been evaluated.Methods and resultsA population of heterogeneous breast tumor cells was extracted from the tumor mass after generating an animal model of triple‐negative breast cancer (TNBC). Spheroid formation was used as an in vitro assay to determine the existence of CSLCs in these cells. MTT assay was used to determine frankincense's cytotoxic activity. An annexin V‐ propidium iodide (PI) staining and scratch test were used to assess the induction of apoptosis and antimetastatic effects of frankincense. The frankincense extract has significant cytotoxic and apoptotic effects on breast CSLCs. Although, the breast CSLCs are more resistant to these impacts than other breast cancer cells.ConclusionOur study is the first report that indicates that frankincense extract has anticancer properties in breast CSLCs. Compared to many anticancer chemicals, which have limited potential to battle cancer stem cells, frankincense is an appropriate option to combat breast CSCs.
High‐resolution analysis of individual spike peptide‐specific CD4+ T‐cell responses in vaccine recipients and COVID‐19 patients
Authors: Karsten Hendrik , Cords Leon , Westphal Tim , Knapp Maximilian , Brehm Thomas Theo , Hermanussen Lennart , Omansen Till Frederik , Schmiedel Stefan , Woost Robin , Ditt Vanessa , Peine Sven , Lütgehetmann Marc , Huber Samuel , Ackermann Christin , Wittner Melanie , Addo Marylyn Martina , Sette Alessandro , Sidney John , Schulze zur Wiesch Julian 
Published: August 2022

AbstractObjectivesPotential differences in the breadth, distribution and magnitude of CD4+ T‐cell responses directed against the SARS‐CoV‐2 spike glycoprotein between vaccinees, COVID‐19 patients and subjects who experienced both ways of immunisation have not been comprehensively compared on a peptide level.MethodsFollowing virus‐specific in vitro cultivation, we determined the T‐cell responses directed against 253 individual overlapping 15‐mer peptides covering the entire SARS‐CoV‐2 spike glycoprotein using IFN‐γ ELISpot and intracellular cytokine staining. In vitro HLA binding was determined for selected peptides.ResultsWe mapped 955 single peptide‐specific CD4+ T‐cell responses in a cohort of COVID‐19 patients (n = 8), uninfected vaccinees (n = 16) and individuals who experienced both infection and vaccination (n = 11). Patients and vaccinees (two‐time and three‐time vaccinees alike) had a comparable number of CD4+ T‐cell responses (median 26 vs. 29, P = 0.7289). Most of these specificities were conserved in B.1.1.529 and the BA.4 and BA.5 sublineages. The highest magnitude of these in vitro IFN‐γ CD4+ T‐cell responses was observed in COVID‐19 patients (median 0.35%), and three‐time vaccinees showed a higher magnitude than two‐time vaccinees (median 0.091% vs. 0.175%, P < 0.0001). Twelve peptide specificities were each detected in at least 40% of subjects. In vitro HLA binding showed promiscuous presentation by DRB1 molecules for several peptides.ConclusionBoth SARS‐CoV‐2 infection and vaccination prime broadly directed T‐cell responses directed against the SARS‐CoV‐2 spike glycoprotein. This comprehensive high‐resolution analysis of spike peptide specificities will be a useful resource for further investigation of spike‐specific T‐cell responses.
Untersuchungen zum Out‐of‐Plane‐Verhalten von nichttragenden Mauerwerkswänden in deutschen Erdbebengebieten
Authors: Helm Lukas , Lönhoff Moritz , Sadegh‐Azar Hamid 
Published: August 2022

AbstractInfolge von Erdbeben müssen nichttragende Trennwände aus Mauerwerk horizontalen Lasten standhalten und dabei spielen auch die Einwirkungen rechtwinklig zur Ebene (Out of Plane) eine bedeutende Rolle. Das Out‐of‐Plane‐Verhalten von Mauerwerkswänden ist aufgrund der stark ausgeprägten nichtlinearen Mechanismen sehr komplex. In aktuellen Bemessungsverfahren werden maßgebende Einflussfaktoren nicht berücksichtigt und es fehlen detaillierte Untersuchungen zu in Deutschland typischen nichttragenden Mauerwerksarten. Es wurden im Rahmen eines Forschungsprojekts umfangreiche analytische, numerische und experimentelle Untersuchungen für tragende Mauerwerkswände durchgeführt und ein Ingenieurmodell zur Bestimmung der Out‐of‐Plane‐Tragfähigkeit unter Berücksichtigung der maßgebenden Parameter entwickelt. Die Ergebnisse dieser Untersuchungen wurden ansatzweise und vereinfacht auf nichttragende Wände übertragen. Hiermit konnten die bisherigen Ansätze in den Erdbebennormen DIN EN 1998‐1/NA (2020) und DIN 4149 (2005) überprüft und dem aktuellen Kenntnisstand angepasst werden. Auf Grundlage der aktualisierten Erdbebengefährdung wurden zudem vereinfachte Nachweismethoden hergeleitet und in Form von Tabellen zusammengefasst. Das Ingenieurmodell und die Grundlagen der Herleitung der vereinfachten Regeln werden anhand eines Anwendungsbeispiels in diesem Beitrag vorgestellt und diskutiert.
Relationship between the turbidity difference and the grade of green tea under Ca2+ acceleration: A preliminary study
Authors: Yu Xiao‐Lan , He Yong 
Published: August 2022

AbstractThe grade of green tea indicates its intrinsic quality and guides consumers when purchasing. Simple, accessible, and on‐site determination of green tea grades is essential for consumers and regulators. In this study, we assumed that the turbidity difference in green tea might indicate its grade, and our results confirmed this hypothesis. The turbidity difference was measured in green tea infusions before and after the Ca2+ acceleration. For the same kind of green tea, it was found that higher grades of green tea had larger turbidity differences. Effects of brewing temperature, brewing time, Ca2+ concentration, and Ca2+ treatment time on the turbidity of green tea infusions were analyzed, and their optimal values were obtained. This study demonstrates that applying the turbidity difference and Ca2+ acceleration could be an accessible method for the on‐site determination of green tea grades.
Facies analysis and distribution of Late Palaeogene deep‐water massive sandstones in submarine‐fan lobes, NW Borneo
Authors: Jamil Muhammad , Siddiqui Numair Ahmed , Usman Muhammad , Wahid Ali , Umar Muhammad , Ahmed Nisar , Haq Izhar Ul , El‐Ghali Mohamed A. K. , Imran Qazi Sohail , Rahman Abdul Hadi Abd , Zhang Shiqi 
Published: August 2022

Deep‐water massive sandstones (DWMS) are characterized by large volumes of sand accumulations which are considered as potential reservoir intervals in deep‐marine environments. Lithological variations and bed thickness statistics are used to interpret the distribution of massive sandstones in a deep‐marine fan‐lobe system. These massive sandstones are interpreted based on lithological heterogeneities and detailed facies analysis in seventeen exposed sections of the Late Palaeogene deposits in Sabah, NW Borneo. Sedimentary logs containing details of lithology textures and structures were used to recognize nine sedimentary facies of DWMS. These lithofacies were then grouped into three sedimentary facies associations: (1) massive facies association with basal part of turbiditic Bouma sequence, (2) massive facies association having soft‐sediment deformation structures, and (3) massive facies association with erosional features. The facies analysis portrays inner to middle submarine fan deposition and was later applied to reconstruct the distribution of a channel‐lobe complex. Individual sandstone bed thicknesses vary from 1 m to more than 8 m and the number of massive sandstones in submarine lobes range from less than 10% to more than 50%. The thicknesses of massive sandstones in channels are more than 8 m, whereas distal lobes have thicknesses from 1–2 m only. These sandstones are concentrated in channels, proximal and medial lobe settings that can also be verified from calculating the average of all maximum thickness of massive sand intervals that is, 8.91 m. The lithological heterogeneities and the processes associated with the deposition of these massive sandstones are vital for potential hydrocarbon reservoirs in the deep‐marine environments around the globe.
An experimental study of the hydrodynamics and contaminant transport in a Y‐shaped confluence with flexible submerged vegetation
Authors: Tong Xuneng , Liu Xiaodong , Yang Ting , Mohapatra Sanjeeb , Hua Zulin , Zhang Yuan , Chu Kejian , Xue Hongqin 
Published: August 2022

AbstractVegetation greatly affects the flow characteristics and contaminant transport in river confluences. In this study, the flow characteristics and contaminant transport in the non‐vegetated/vegetated Y‐shaped confluence were explored systematically through a series of experiments. A total of 10 scenarios were designed to answer the three main research questions: what is the difference between the flow characteristics and contaminant transport in (1) asymmetrical and Y‐shaped confluences; (2) non‐vegetated/vegetated Y‐shaped confluences; (3) vegetated Y‐shaped confluences with different confluence ratios? The experimental results revealed that vegetation remarkably changes the internal flow structure in Y‐shaped confluences. Briefly, the velocity profile can be divided into three vertical layers within the vegetated system, but it remains nearly constant in the non‐vegetated channel. Vegetation changes the circulation location and reduces the intensity of the secondary current, weakening the strength of contaminant mixing. However, the turbulent kinetic energy within the vegetated system is larger than that in the non‐vegetated case, and it peaks at the top of the vegetation canopy. Under different confluence ratio cases, the overall fluctuation of the longitudinal dispersion coefficients along the cross‐sections in the mainstream was similar but increasing the confluence ratio causes the circulation to appear to advance and enhances its intensity. In addition, the vegetation density (200 item/m2) in this study render the manning roughness coefficient at 0.068, which is larger than that under lower vegetation density cases. The outcomes from this study are helpful for both environmental and river management applications.
Combining sediment source tracing techniques with traditional monitoring: The “Arvorezinha catchment” experience
Authors: Minella Jean P. G. , Merten Gustavo H. , Schlesner Alexandre , Bernardi Felipe , de Barros Cláudia A. P. , Tiecher Tales , Ramon Rafael , Evrard Olivier , dos Santos Danilo Rheinheimer , Reichert José Miguel , Tassi Rutineia 
Published: August 2022

AbstractTo truly understand the hydrologic and erosive processes that occur at the catchment scale regarding land use and soil management changes, intensive monitoring is required over a long period. Variables such as precipitation, flow rate and suspended sediment concentration are the fundamentals needed to estimate sediment yield (SY). However, in order to shed more light on the effects of soil management changes on SY, traditional hydrologic monitoring techniques can be paired with sediment tracing to identify sediment sources. In addition, mathematical models that predict erosion and SY can also help understand the dynamics of erosion and deposition between the hillslope and stream channel. Given the above, this article provides an overview of almost 20 years of monitoring (2002–2021) in the Arvorezinha experimental catchment (1.23 km2) located on the edge of the Brazilian meridional plateau in southern Brazil, which is subject to extreme erosion due to a combination of factors related to intensive agriculture and steep slopes. The catchment was selected as a study site to evaluate the effects of land‐use changes and soil conservation management on hydrology and SY. The text reviews the history of the study, synthesizes the main results and describes the evolution of the monitoring techniques used while giving special attention to the fingerprinting approach. In addition, the article discusses the importance of catchment‐scale studies for teaching, generating technical‐scientific knowledge and fostering collaboration between national and international research groups.
Analysing the capability of a catchment's spectral signature to regionalize hydrological parameters
Authors: Fragoso‐Campón Laura , Durán‐Barroso Pablo , Quirós Elia 
Published: August 2022

AbstractWater resource management in ungauged catchments is complex due to uncertainties around the hydrological parameters that characterize streamflow behaviour. These parameters are usually defined by regionalization approaches, in which the hydrological response patterns of ungauged basins are inferred from those of gauged basins. Regression‐based methods using physical properties derived from cartographic data sources are widely used. The current remote sensing techniques offer new opportunities for the regionalization of hydrological parameters since the hydrological response depends on the physical attributes related to the spectral responses of a given land surface. Moreover, machine learning approaches have not been specifically applied to the regionalization of hydrological parameters in forested areas. This work studies the capability of a catchment's spectral signature based on Sentinel‐1 and Sentinel‐2 data to address a regression‐based regionalization of hydrological model parameters using a machine learning approach. Hydrological modelling was conducted by the HBV‐light model. We tested the random forest algorithm in several regionalization scenarios: the new approach using the catchments' spectral signature, the traditional method using physical properties and a fusion of these methods. The calibration results were excellent (median KGE = 0.83), and the regionalized parameters achieved good performance, in which the three scenarios showed almost the same goodness of fit (median KGE = 0.45–0.50). We found that the effectiveness depends on the climatic environment and that predictions in humid catchments exhibited better performance than those in the driest catchments. The physical approach (median KGE = 0.71) exhibited better performance than the spectral approach (median KGE = 0.64) in humid catchments, whereas spectral regionalization (median KGE = 0.33) enhanced the physical scenario in the driest catchments (median KGE = 0.25). Our results confirm that regionalization is still challenging in drier climates, such as in the Mediterranean environment. The new spectral approach showed promising results and it was effective in the analysis of the relationship between the spectral response of the territory and its hydrological characteristics, specially, where no cartographic data is available.
The strong fractional choice number of 3‐choice‐critical graphs
Authors: Xu Rongxing , Zhu Xuding 
Published: August 2022

AbstractA graph is called 3‐choice‐critical if is not 2‐choosable but any proper subgraph of is 2‐choosable. A graph is strongly fractional ‐choosable if is ‐choosable for all positive integers for which . The strong fractional choice number of is is strongly fractional ‐choosable. This paper determines the strong fractional choice number of all 3‐choice‐critical graphs.
Kinetics of the thermolysis of 3‐nitro‐2,4‐dihydro‐3H‐1,2,4‐triazol‐5‐one (NTO) and nanosize NTO the presence of nickel‐zinc‐cobalt ferrite
Authors: Dave Pragnesh N. , Sirach Ruksana , Chaturvedi Shalini 
Published: August 2022

AbstractThis study deals with the evaluation of the catalytic activity of quaternary nickel‐zinc‐cobalt ferrite (NiZnCoF) nanoparticles on the thermal decomposition of 3‐nitro‐2,4‐dihydro‐3H‐1,2,4‐triazol‐5‐one (NTO). Nanosize NiZnCoF has been successfully synthesized using the co‐precipitation method. The effect of 5% by mass NiZnCoF on the thermolysis of NTO and NTO with nanosize (nNTO) has been studied using simultaneous thermal analysis. In the presence of NiZnCoF additive, the decomposition of NTO and nNTO was increased by 8.55 and 7.68°C, indicating that the additive stabilizes NTO and nNTO. The DSC peak temperature also suggests the presence of NiZnCoF decreases the nNTO's exothermic curve by 5.62°C. The DSC peak curve of NTO in the presence of NiZnCoF was shifted from 276.35 to 272°C. The activation energy calculations suggested that the high activation energy of NTO can be reduced ∼82–87 kJ mol−1 by nanosizing NTO followed by the incorporation of NiZnCoF.
Manipulating Conjugated Polymer Backbone Dynamics through Controlled Thermal Cleavage of Alkyl Side Chains
Authors: Zhao Haoyu , Shanahan Jordan J. , Samson Stephanie , Li Zhaofan , Ma Guorong , Prine Nathaniel , Galuska Luke , Wang Yunfei , Xia Wenjie , You Wei , Gu Xiaodan 
Published: August 2022

AbstractThe morphological stability of an organic photovoltaic (OPV) device is greatly affected by the dynamics of donors and acceptors occurring near the device's operational temperature. These dynamics can be quantified by the glass transition temperature (Tg) of conjugated polymers (CPs). Because flexible side chains possess much faster dynamics, the cleavage of the alkyl side chains will reduce chain dynamics, leading to a higher Tg. In this work, the Tgs for CPs are systematically studied with controlled side chain cleavage. Isothermal annealing of polythiophenes featuring thermally cleavable side chains at 140 °C, is found to remove more than 95% of alkyl side chains in 24 h, and raise the backbone Tg from 23 to 75 °C. Coarse grain molecular dynamics simulations are used to understand the Tg dependence on side chain cleavage. X‐ray scattering indicates that the relative degree of crystallization remains constantduring isothermal annealing process. The effective conjugation length is not influenced by thermal cleavage; however, the density of chromophore is doubled after the complete removal of alkyl side chains. The combined effect of enhancing Tg and conserving crystalline structures during the thermal cleavage process can provide a pathway to improving the stability of optoelectronic properties in future OPV devices.