bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal variation in calcium treatment after thyroidectomy as surrogate for post-operative hypocalcemia: a retrospective register-based national cohort study
Authors: Kördel Carl , Koman Anna , Bränström Robert , Stenman Adam 
Published: March 2022

AbstractBackgroundHypocalcemia is one of the most common complications of thyroidectomy, and vitamin D deficiency has been found to be an independent risk factor. Sweden is located north of the 55th latitude, resulting in a significant seasonal variation in sun exposure, thereby large variation in the naturally occurring levels of vitamin D. This study aimed to determine if there is a correlation between season of surgery and post-thyroidectomy hypocalcemia.MethodsWe conducted a retrospective register-based observation study on patients who had undergone total thyroidectomy during 2008–2015. In total, 7125 patients operated in Swedish facilities were identified via the Scandinavian Quality Register for Thyroid, Parathyroid, and Adrenal Surgery (SQRTPA). Patients operated during February–April were included in the dark group and patients operated during August–October were included in the bright group. Further stratification was made on the indication for surgery. The primary outcome was post-operative calcium treatment due to hypocalcemia, defined as having received calcium orally or intravenously before discharge.ResultsThe risk of receiving post-operative calcium treatment was significantly lower in the bright group (29.7%) compared to the dark group (35.1%), with a relative risk of 0.846 (P < 0.001). This correlation held true if the indication for surgery was goiter or thyrotoxicosis. For malignancy, there was no significant difference between the groups.ConclusionIn this cohort, total thyroidectomy performed during August–October was associated with a lower rate of calcium treatment given post-operatively when compared to total thyroidectomy performed during February–April. This would indicate a decreased risk of post-operative hypocalcemia if surgery was carried out after the brighter season.
Siah-1-interacting protein regulates mutated huntingtin protein aggregation in Huntington’s disease models
Authors: Latoszek Ewelina , Wiweger Małgorzata , Ludwiczak Jan , Dunin-Horkawicz Stanisław , Kuznicki Jacek , Czeredys Magdalena 
Published: March 2022

Abstract
Background
Huntington’s disease (HD) is a neurodegenerative disorder whereby mutated huntingtin protein (mHTT) aggregates when polyglutamine repeats in the N-terminal of mHTT exceeds 36 glutamines (Q). However, the mechanism of this pathology is unknown. Siah1-interacting protein (SIP) acts as an adaptor protein in the ubiquitination complex and mediates degradation of other proteins. We hypothesized that mHTT aggregation depends on the dysregulation of SIP activity in this pathway in HD.

Results
A higher SIP dimer/monomer ratio was observed in the striatum in young YAC128 mice, which overexpress mHTT. We found that SIP interacted with HTT. In a cellular HD model, we found that wildtype SIP increased mHTT ubiquitination, attenuated mHTT protein levels, and decreased HTT aggregation. We predicted mutations that should stabilize SIP dimerization and found that SIP mutant-overexpressing cells formed more stable dimers and had lower activity in facilitating mHTT ubiquitination and preventing exon 1 mHTT aggregation compared with wildtype SIP.

Conclusions
Our data suggest that an increase in SIP dimerization in HD medium spiny neurons leads to a decrease in SIP function in the degradation of mHTT through a ubiquitin–proteasome pathway and consequently an increase in mHTT aggregation. Therefore, SIP could be considered a potential target for anti-HD therapy during the early stage of HD pathology.
Prevalence of neurodevelopmental disorders and their impact on the health and social well-being among looked after children (LAC): a systematic review protocol
Authors: Heady Nicola , Watkins Alan , John Ann , Hutchings Hayley 
Published: March 2022

AbstractBackgroundLooked after children (LAC) that are placed in either a foster, kinship, residential care setting or transition to adoption continue to develop debilitating disorders that significantly impact their overall health and social well-being. The prevalence of these disorders is often depicted under broad categories such as mental, behavioural or neurodevelopmental disorders (NDDs). Limited in research is the prevalence of what specific disorders fall under these broad categories. NDDs such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) which fall under an umbrella group in the expert field of genetics and neuropsychiatry will be explored. Unsupported, these disorders can lead to suboptimal health and social outcomes for both the child and family. In the general population, the prevalence of these NDDs and impacts on health and social well-being are relatively well documented, but for minority groups such as LAC, research is extremely limited. This review aims to estimate the prevalence of NDDs among LAC and explore how they might impact the health and social well-being of these vulnerable children. If feasible, the review will compare the prevalence rates to those children who are not looked after, to illuminate any differences or similarities between populations.MethodsPubMed, ASSIA, IBSS, Web of Science, PsychINFO, Scopus, Psych articles, Social Care Online, secondary, grey literature and government publications will be searched to identify any eligible studies. No restrictions will be placed on country, design or year of publication. Studies must provide primary data on the prevalence or incidence of NDDs for individuals < 25 years of age, supported by either a diagnostic code, standardised diagnostic assessment tool or survey response. The Joanna Briggs Institute (JBI) critical appraisal tools will be utilised to assess the quality and bias and the random-effects model used to estimate a pooled prevalence of NDDs.DiscussionAttaining an estimated prevalence of these NDDs and identifying any impacts on health and social well-being might inform key stakeholders in health, educational and social sectors with important information that might aid in the early identification and intervention to safeguard and meet the unique needs of these children.Systematic review registrationPROSPEROCRD4201913103.
Look-ahead energy efficient VM allocation approach for data centers
Authors: Çağlar İlksen , Altılar Deniz Turgay 
Published: March 2022

AbstractEnergy efficiency is an important issue for reducing environmental dissipation. Energy efficient resource provisioning in cloud environments is a challenging problem because of its dynamic nature and varied application workload characteristics. In the literature, live migration of virtual machines (VMs) among servers is commonly proposed to reduce energy consumption and to optimize resource usage, although it comes with essential drawbacks, such as migration cost and performance degradation. Energy efficient provisioning is addressed at the data center level in this research. A novel efficient resource management algorithm for virtualized data centers that optimizes the number of servers to meet the requirements of dynamic workloads without migration is proposed in this paper. The proposed approach, named Look-ahead Energy Efficient VM Allocation (LAA), contains a Holt Winters-based prediction module. Energy efficiency and performance are inversely proportional. The energy-performance trade-off relies on periodic comparisons of the predicted and active numbers of servers. To evaluate the proposed algorithm, experiments are conducted with real-world workload traces from Google Cluster. LAA is compared with the best approach provided by CloudSim based on VM migration called Local Regression-Minimum Migration Time (LR-MMT). The experimental results show that the proposed algorithm leads to a consumption reduction of up to 45% to complete one workload compared with the LR-MMT.
Impact of attitude towards entrepreneurship education and role models on entrepreneurial intention
Authors: Amofah Kwaku , Saladrigues Ramon 
Published: March 2022

AbstractIn this paper, we investigate entrepreneurial intention by applying the Theory of Planned Behaviour (TPB) by Ajzen (1991). We specifically examine the role of gender on entrepreneurial education and role models or parental self-employment (PSE), by carrying out a multi-group analysis (MGA). We used a web-based questionnaire to collect information from 216 students at a Spanish university. Data are analysed with the help of Structural Equation Modelling (SEM)–Partial Least Square (PLS). We conducted a tripartite analysis on Complete, Male, and Female Models. Regarding the Complete and Male Models, all the primary hypotheses (5 in total) were accepted, compared with four for the Female Model. In this study, the primary hypotheses focus on the core variables of the TPB. We recommend the institutionalization of traineeship, elective courses, conference and workshops on entrepreneurship to boost the entrepreneurial spirit of students. Though this study has confirmed the applicability of the TPB model to entrepreneurial intention, we did not find a significant relationship between Males and Females about their entrepreneurial intentions for some relationships. However, this study suggests that the relationship between PSE and perceived behavioural control (PBC) is stronger for Males than Females Our results have implications for entrepreneurship education scholars, program evaluators, and policymakers.
Swertiamarin ameliorates inflammation and oxidative damage in autoimmune encephalomyelitis mouse model
Authors: Ibrahim Hairul-Islam Mohamed , Ahmed Emad A. , Alzahrani Abdullah M. , Sayed Abdullah A. , Hanieh Hamza 
Published: March 2022

AbstractMultiple sclerosis (MS) is a degenerative autoimmune disease attacks the myelin sheath of the central nervous system (CNS) neurons causing different disabilities. According to recent evidence, the main bioactive component in Enicostema axillare, the Swrtiamarin (SM) has been found to exert anti-inflammatory and antioxidant activities against several diseases. However, SM activities in treatment of autoimmune diseases remain to be explored. Herein, we used a murine model of MS, to show that SM treatment ameliorates the severity of experimental autoimmune encephalomyelitis (EAE). This occurs through reducing the levels of pro-inflammatory cytokines and infiltration of CD4+CD45+ cells into CNS. That was associated with a reduction in the expression of STAT3 and NFkB in CD4+ T cells under Th17 and LPS-stimulated macrophages. Furthermore, in silico studies revealed that SM interacts with NF-E2-related factor 2 (NRF2), and therefore, suppressed oxidative stress by inducing formation NRF2-antioxidant response element (ARE) complex. We found that SM is an agonist of NRF2 complex regulating the total CD4 population and antioxidant markers in EAE mice. Molecular docking analysis showed a stable and higher binding affinity between SM and NRF2. Results revealed that SM treatment increased the complex formation between ARE and NRF2 where immunoprecipitation methods showed a higher binding affinity of ARE to NRF2 in SM treated animals. Complex formation triggered ARE cascade of antioxidant gene clusters and reduces the MS pathological alterations in EAE mice model. Current data proposed SM as an effective biomolecule in treatment of MS and controlling neuronal damage through inhibiting oxidative stress markers and targeting NRF2.
Mind the gap: IgG4-related disease mimicking infectious cerebral mass lesions
Authors: De Maria Andrea , Sepulcri Chiara , Tutino Stefania , Briano Federica , Toscanini Federica , Fiaschi Pietro , Zona Gianluigi , Gaggero Gabriele , Bassetti Matteo 
Published: March 2022

Abstract
Background
Cerebral intraparenchymal masses represent usually a neoplastic, or infectious differential diagnostic workup in neurology or infectious disease units.

Case presentation
Our patient was an 82-year-old male presenting with seizures, cerebral masses and a history of past treated pulmonary tuberculosis. Initial workup included a differential diagnosis of an infectious mass/multiple abscess. After exclusion of infectious or primary neoplastic origins by negative HIV serology, the absence of immune suppression, endocarditic lesions, negative results of blood cultures and bronchoalveolar lavage, negative cerebrospinal fluid workout on spinal tap led to exclusion of infectious causes. A surgical procedure was performed to access one of the lesions. This yielded a firm, cyst-like mass of histiocytic granulomatous tissue with a conspicuous plasmacellular component and a relevant IgG4 plasmacellular component consistent with IgG4-related disease.
Steroid treatment determined conspicuous improvement and led to discharge of the patient.

Conclusion
Parenchymal IgG4-related disease may be included as a new entity in the differential diagnosis of single or multiple cerebral masses in addition to infectious or neoplastic etiology.
The legacy of the reformasi: the role of local government spending on industrial development in a decentralized Indonesia
Authors: Wiryawan Bangkit A. , Otchia Christian 
Published: March 2022

AbstractStarting in 2001 the Government of Indonesia employed the Regional Autonomy Law, providing larger fiscal role to the province and district governments. However, our understanding of its impacts on development in Indonesia is still limited. This paper seeks to find the relationship between increasing local governments’ capital expenditure and industrial development with focus in the non-oil and gas sector. Capital spending is thought to have moderation effect on investment, the main channel for industrialization, that should contribute to industrial growth. Our System GMM results suggest that there are positive and significant correlations between capital spending and industrial growth, presenting evidence of local governments’ role. However, we fail to find significant moderation effect between local capital spending and industrial investment towards the sector’s growth. This poses problem for industrialization at the local level. Decentralization progress in Indonesia has been institutionally anchored by the central government, particularly with the introduction of concurrent affairs in 2004 that allowed Jakarta to take a major developmental role in districts and provinces at the cost of lesser local governments’ role. Our study proposes a new institutional model that promote better central–local collaboration.
An environmental information system for the exploration of energy systems
Authors: Rink Karsten , Şen Özgür Ozan , Schwanebeck Malte , Hartmann Tim , Gasanzade Firdovsi , Nordbeck Johannes , Bauer Sebastian , Kolditz Olaf 
Published: March 2022

AbstractThe transition to renewable energy sources requires extensive changes to the energy system infrastructure, ranging from individual households to the national scale. During this transition, stakeholders must be able to make informed decisions, researchers need to investigate possible options and analyse scenarios, and the public should be informed about developments and options for future infrastructure. The data and parameters required for this are manifold and it is often difficult to create an overview of the current situation for a region of interest. We propose an environmental information system for the visualisation and exploration of large collections of heterogeneous data in the scope of energy system infrastructure and subsurface geological energy storage technologies. Based on the study area of Schleswig-Holstein, a federal state in Germany, we have set up a virtual geographic environment integrating GIS data, topographical models, subsurface information, and simulation results. The resulting application allows users to explore data collection within a unified context in 3D space, interact with datasets, and watch animations of selected simulation scenarios to gain a better understanding of the complex interactions of processes and datasets. Based on the cross-platform game engine Unity, our framework can be used on regular PCs, head-mounted displays, and virtual reality environments and can support domain scientists during assessment and exploration of the data, encourages discussions and is an effective means for outreach activities and presentations for stakeholders or the interested public.
Bromo activity over the last decade: consistent passive degassing and source magma evolution
Authors: Alfianti Hilma , Bani Philipson , Sumaryadi Mamay , Primulyana Sofyan , Marlia Mita , Saing Ugan B. , Haerani Nia , Gunawan Hendra 
Published: March 2022

AbstractBromo is among the very active volcanoes in Indonesia and is known for its recurrent and long-lasting eruptive manifestations. Past volcanic gas studies have revealed Bromo as one of the principal sources of volcanic degassing in Indonesia. This high degassing from Bromo volcano is further characterized in this work, based on more than 10 years of intermittent ground-based gas measurements, combined with daily SO2 mass, captured by the OMI sensor. Over the past decade, Bromo has released 0.7 Tg of SO2 into the atmosphere, representing 3% of the volcanic degassing budget of Indonesia and 0.3% of the global volcanic SO2 emission budget outside eruptive periods. Results also reveal that 18.8 Tg of H2O, 2.0 Tg of CO2, 0.1 Tg of H2S, and 0.005 Tg of H2 were released from the Bromo volcano in one decade. About 81% of these gases are released passively between eruptive events. The chemistry of the eruptive products, sampled between 2001 and 2019, indicate that Bromo volcanic activity is sustained by a basaltic-andesite to basalt trachy-andesite magma source with a transition from medium-K to high-K composition. Such an evolution associated to a C-rich gas likely resulted from a low partial melting and sediment contribution to the genesis of the source magma. New magma injections into the reservoir and fractional crystallization have further amplified the changes of magma composition. Finally, we speculate that the shallow reservoir replenishment, in response to the continuous strong degassing is the driving mechanism behind the Bromo frequent eruptive events.
Whose ability and growth matter? Gender, mindset and performance in physics
Authors: Malespina Alysa , Schunn Christian D. , Singh Chandralekha 
Published: March 2022

AbstractBackgroundMotivational factors are one active area of research that aims to increase the inclusion of women in physics. One of these factors that has only recently gained traction in physics is intelligence mindset (i.e., the belief that intelligence is either innate and unchangeable or can be developed). We studied 781 students in calculus-based Physics 1 to investigate if their mindset views were separable into more nuanced dimensions, if they varied by gender/sex and over time, and if they predicted course grade. Confirmatory factor analysis was used to divide mindset survey questions along two dimensions: myself versus others and growth versus ability aspects of mindset. Paired and unpairedt-tests were used to compare mindset factors over time and between genders, respectively. Multiple regression analysis was used to find which mindset factors were the best predictors of course grade.ResultsThis study shows that intelligence mindset can be divided into four factors: My Ability, My Growth, Others’ Ability, and Others’ Growth. Further, it reveals that gender differences are more pronounced in the “My” categories than the “Others’” categories. At the start of the course, there are no gender differences in any mindset component, except for My Ability. However, gender differences develop in each component from the start to the end of the course, and in the My Ability category, the gender differences increase over time. Finally, we find that My Ability is the only mindset factor that predicts course grade.ConclusionThese results allow for a more nuanced view of intelligence mindset than has been suggested in previous interview and survey-based work. By looking at the differences in mindset factors over time, we see that learning environments affect women’s and men’s intelligence mindsets differently. The largest gender difference is in My Ability, the factor that best predicts course grade. This finding has implications for developing future mindset interventions and opens new opportunities to eliminate classroom inequities.
Multiattribute analysis of channel architectural elements within the deepwater Taranaki Basin, 3D Romney data
Authors: Stroud Brittany , Barber Grace , Bedle Heather 
Published: March 2022

The Taranaki Basin is located offshore west of North Island, New Zealand. Within the study area, deepwater channel systems are present as a result of plate boundary movement and clastic deposition during the Plio-Pleistocene. Multiattribute analysis revealed a few interesting features that we identified and interpreted. After refining the horizon of focus, we have concluded some interpretations as noise, whereas others were confirmed as geologic deposits. In one funny-looking thing (FLT 1), we interpreted high energy and high sweetness response along the northwestern portion of the main channel body as a sand-rich levee deposit and, in a second funny-looking thing (FLT 2), scalloping and elongate “finger-like” geometries as noise. The visualization and interpretation of these features through seismic attributes allow for optimized exploration, and therefore an opportunity for hydrocarbon extraction, within the Taranaki Basin. Geologic feature: Deep marine channel system: sandy channel fill to the northwest (FLT 1); interesting features in the center of the time slice (FLT 2) Seismic appearance: Chaotic, discontinuous reflectors with a high-energy response (FLT 1); chaotic high-variance features (FLT 2) Alternative interpretations: Overlapping sand-dominated channel (FLT 1); crevasse splays, fan lobes, distributary channels, ravines, and incisions (FLT 2) Age: Plio-Pleistocene Location: Taranaki Basin, western offshore North Island, New Zealand Seismic data: Provided by Anadarko Taranaki Company Analysis tool: A 3D reflection seismic, geometric, and physical seismic attributes