bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a quantitative PCR-based method for chimerism analysis of Japanese donor/recipient pairs
Authors: Minakawa Keiji , Ono Satoshi , Watanabe Mao , Sato Yuka , Suzuki Saki , Odawara Shou , Kawabata Kinuyo , Ueda Koki , Nollet Kenneth E. , Sano Hideki , Ikezoe Takayuki , Kikuta Atsushi , Ikeda Kazuhiko 
Published: December 2022

AbstractChimerism analysis is a surrogate indicator of graft rejection or relapse after allogeneic hematopoietic stem cell transplantation (HSCT). Although short tandem repeat PCR (STR-PCR) is the usual method, limited sensitivity and technical variability are matters of concern. Quantitative PCR-based methods to detect single nucleotide polymorphisms (SNP-qPCR) are more sensitive, but their informativity and quantitative accuracy are highly variable. For accurate and sensitive chimerism analysis, a set of KMR kits (GenDx, Utrecht, Netherlands), based on detection of insertions/deletions (indels) by qPCR, have been developed. Here, we investigated informativity and validated the accuracy of KMR kits in Japanese donor/recipient pairs and virtual samples of DNA mixtures representative of Japanese genetic diversity. We found that at least one recipient-specific marker among 39 KMR-kit markers was informative in all of 65 Japanese donor/recipient pairs. Moreover, the percentage of recipient chimerism estimated by KMRtrack correlated well with ratios of mixed DNA in virtual samples and with the percentage of chimerism in HSCT recipients estimated by STR-PCR/in-house SNP-qPCR. Moreover, KMRtrack showed better sensitivity with high specificity when compared to STR-PCR to detect recipient chimerism. Chimerism analysis with KMR kits can be a standardized, sensitive, and highly informative method to evaluate the graft status of HSCT recipients.
Reduced heart rate variability and expressive suppression interact to prospectively predict COVID-19 pandemic-related post-traumatic stress symptoms
Authors: Dell’Acqua Carola , Mura Francesca , Messerotti Benvenuti Simone , Patron Elisabetta , Palomba Daniela 
Published: December 2022

AbstractThe COVID-19 pandemic is a unique period of stress that, in some cases, led to post-traumatic stress symptoms (PTSSs). Emotion regulation strategies are known to modulate the emotional response to stressful events. Expressive suppression (ES) is a maladaptive strategy related to the exacerbation of the physiological stress response. Heart rate variability (HRV), an index of cardiac autonomic balance strictly related to ES, was also shown to predict PTSSs. This was the first study to investigate whether the pre-pandemic ES use and resting-state HRV predicted pandemic-related PTSSs. Before the pandemic, 83 (58 females) university students completed the Emotion Regulation Questionnaire (ERQ), self-report measures of anxiety and depressive symptoms, and a three-minute resting-state electrocardiogram recording. After 12 months, 61 (45 females) participants completed a self-report measure of pandemic-related PTSSs and repeated the self-report psychological measures. Pre-pandemic anxiety symptoms prospectively predicted greater PTSSs. Moreover, a significant interaction between HRV and ES in predicting PTSSs emerged, whereby those who had higher levels of ES and reduced HRV showed higher PTSSs. These findings suggest that an integrated assessment of HRV and ES might be useful for identifying individuals who are more vulnerable to the development of PTSSs during crises.
Phenolic composition of ten plants species used as ethnoveterinary medicines in Omusati and Kunene regions of Namibia
Authors: Eiki N. , Manyelo T. G. , Hassan Z. M. , Lebelo S. L. , Sebola N. A. , Sakong B. , Mabelebele M. 
Published: December 2022

AbstractThe therapeutic benefits of phenolic compounds found in plants are well known. The purpose of this study was to determine the phenolic content of ten plant species used as ethnoveterinary treatments in Namibia’s Omusati and Kunene regions. The plants of concern were Aloe esculenta, Fockea angustifolia, Boscia albitrunca, Combretum imberbe, Acacia nilotica, Colophospermum mopane, Acacia erioloba, Ziziphus mucronata, Ximenia americana, and Salvadora persica. An LC–MS approach was used to identify the compounds. To analyse high-resolution UPLC-UV/MS, a Waters Acquity ultra-performance liquid chromatograph (UPLC) with a photodiode array detector was connected to a Waters Synapt G2 quadrupole time-of-flight mass spectrometer (MS). The current study identified a total of 29 phenolic compounds. Flavonoids (epicatechin, (-)-Epigallocatechin, and rutin,) were the most abundant, followed by 2R, 3S-Piscidic acid. Methylisocitric acid was found in all species investigated, with the highest quantities in A. esculenta and X. americana leaf extracts. There were differences in composition and quantity of phenolic compounds in aerial and ground sections between species. The overall findings of the present study would act as a standard for subsequent investigations into the pharmacological potentials of plants species utilized as ethnoveterinary remedies. Priority should be given to isolating, purifying, and defining the active compounds responsible for these plants' activity.
Tract-based white matter hyperintensity patterns in patients with systemic lupus erythematosus using an unsupervised machine learning approach
Authors: Rumetshofer Theodor , Inglese Francesca , de Bresser Jeroen , Mannfolk Peter , Strandberg Olof , Jönsen Andreas , Bengtsson Anders , Nilsson Markus , Knutsson Linda , Lätt Jimmy , Steup-Beekman Gerda M. , Huizinga Tom W. J. , van Buchem Mark A. , Ronen Itamar , Sundgren Pia C. 
Published: December 2022

AbstractCurrently, little is known about the spatial distribution of white matter hyperintensities (WMH) in the brain of patients with Systemic Lupus erythematosus (SLE). Previous lesion markers, such as number and volume, ignore the strategic location of WMH. The goal of this work was to develop a fully-automated method to identify predominant patterns of WMH across WM tracts based on cluster analysis. A total of 221 SLE patients with and without neuropsychiatric symptoms from two different sites were included in this study. WMH segmentations and lesion locations were acquired automatically. Cluster analysis was performed on the WMH distribution in 20 WM tracts. Our pipeline identified five distinct clusters with predominant involvement of the forceps major, forceps minor, as well as right and left anterior thalamic radiations and the right inferior fronto-occipital fasciculus. The patterns of the affected WM tracts were consistent over the SLE subtypes and sites. Our approach revealed distinct and robust tract-based WMH patterns within SLE patients. This method could provide a basis, to link the location of WMH with clinical symptoms. Furthermore, it could be used for other diseases characterized by presence of WMH to investigate both the clinical relevance of WMH and underlying pathomechanism in the brain.
Day-to-Day Variability of Clinical Feeding and Swallowing Performance in School-Age Self-Feeding Children With Cerebral Palsy
Authors: Malandraki Georgia A. , Kantarcigil Çagla , Craig Bruce A. , Zhang Yumin , Gordon Andrew M. 
Published: December 2022

Purpose:
We aimed to examine the day-to-day variability of feeding and swallowing performance and mealtime duration in school-age self-feeding children with spastic cerebral palsy (SCP) across 15 days.

Method:

Thirteen children with SCP (ages 5;10 [years;months]–17;6) participated. Children were divided into unilateral (UCP,
n
= 6) and bilateral (BCP,
n
= 7) SCP groups. Feeding/swallowing assessments using the Dysphagia Disorder Survey (DDS) were conducted and total mealtime durations (TMDs) were calculated for all days. DDS Part 1 (factors related to feeding) and DDS Part 2 (signs of oropharyngeal difficulties) components were rated. Mixed-effects models were used to compare group means and estimate between- and within-subject variances in each group. Likelihood ratio tests were used to determine best covariance structure and compare variance types across groups.

Results:

Within-subject variance for all three variables, DDS Part 1, 2, and TMD, across days was larger in the BCP group than the UCP group (Part 1:
p
= .0036, Part 2:
p
= .0002, and TMD:
p
= .0005) and the between-subject variance was larger in the BCP group for DDS Part 2 (
p
= .0362). The UCP group presented with lower (milder) DDS scores (Part 1:
p
= .0160; Part 2:
p
= .0141) and shorter TMD
(p
= .0077) than the BCP group across days. Furthermore, both groups exhibited greater variability in DDS Part 2 than 1 (
p
< .0001).

Conclusion:
These preliminary results emphasize the need to account for day-to-day variability when evaluating swallowing especially in children with BCP and provide preliminary ranges of performance that could be useful for clinical prognosis and future treatment research.

Supplemental Material:

https://doi.org/10.23641/asha.21669611
Retracted: Research on wavelet neural network PID control of maglev linear synchronous motor
Authors: Mao Jun , Ma Jun 
Published: December 2022

AbstractRetraction: [Jun Mao, Jun Ma, Research on wavelet neural network PID control of maglev linear synchronous motor, IET Circuits, Devices & Systems 2022 (https://doi.org/10.1049/cds2.12136)].The above article from IET Circuits, Devices & Systems, published online on 8 December 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor‐in‐Chief, Harry E. Ruda, the Institution of Engineering and Technology (the IET) and John Wiley and Sons Ltd. This article was published as part of a Guest Edited special issue. Following an investigation, the IET and the journal have determined that the article was not reviewed in line with the journal’s peer review standards and there is evidence that the peer review process of the special issue underwent systematic manipulation. Accordingly, we cannot vouch for the integrity or reliability of the content. As such we have taken the decision to retract the article. The authors have been informed of the decision to retract.
Multi‐parameters dynamic scheduling with energy management for electric vehicle charging stations
Authors: Wang Haodong , Chen Ning , Liu Zan , Zhang Songwei , Li Zhiguo , Qiu Tie 
Published: December 2022

AbstractTo make charging of electric vehicles (EVs) more convenient, the service providers of charging stations (CSs) establish a large number of CSs. Existing methods address the problem of reducing costs and increasing revenue for the service providers from multiple aspects, such as CS location optimisation and charging pricing strategy. This study proposes multi‐parameters‐based‐dynamic scheduling with energy management for the CSs, considering energy management and EV charging scheduling (EVCS). A fully functional battery management system is designed for energy storage. A multi‐parameters optimisation algorithm is proposed by designing the CS selection operator based on alternative set and adjusting parameters. The experiments show that our proposed algorithms got better performance in terms of optimisation effect, the number of iterations, and stability.
MTSCANet: Multi temporal resolution temporal semantic context aggregation network
Authors: Zhang Haiping , Ma Conghao , Yu Dongjin , Guan Liming , Wang Dongjing , Hu Zepeng , Liu Xu 
Published: December 2022

AbstractTemporal action localisation is a challenging task, and video context is crucial to localisation actions. Most existing cases that incorporate temporal and semantic contexts into video features suffer from single contextual representation and blurred temporal boundaries. In this study, a multi‐temporal resolution pyramid structure model is proposed. Firstly, a temporal‐semantic context aggregation module (TSCF) is designed to assign different attention weights to temporal contexts and combine them with multi‐level semantics into video features. Secondly, for the problem of large differences in the time span between different actions in the video, a local‐global attention module is designed to combine local and global temporal dependencies for each temporal point to obtain a more flexible and robust representation of contextual relations. The redundant representation of the convolution kernel is reduced by modifying the convolution and the arithmetic power is redeployed at a microscopic granularity. To verify the effectiveness of the model, extensive experiments on three challenging datasets are performed. On THUMOS14, the best performance is obtained in IoU@0.3–0.6 with an average mAP of 47.02%. On ActivityNet‐1.3, an average mAP of 34.94% was obtained. On HACS, an average mAP of 28.46% was achieved.
A novel superimposed component‐based protection method for multi‐terminal transmission lines using phaselet transform
Authors: Ansari Sajad , Ghaffarzadeh Navid 
Published: December 2022

AbstractThis paper presents a novel protection method for transmission lines that estimates the superimposed component phasor using phaselet transform. The phaselet transform computes the phasors over variable‐lenfgth data window at the instant of a fault, so it can estimate the phasor less than one full cycle. The presented method phaselets are used to extract the superimposed component instead of the samples and the initial phase angle difference (IPAD) of the superimposed currents between terminals is used to detect internal and external faults. The main contribution of this method is an accurate, fast and robust superimposed component‐based algorithm that uses the phaselet transform to estimate the phasor of the superimposed component for distinguishing internal faults from external faults; this method is also reliable against transients such as current transformer (CT) saturation and capacitor bank switching. To evaluate the performance of the proposed method, a three‐terminal transmission line is modelled in the alternative transients program/electromagnetic transients program (ATP/EMTP) software and several cases including fault and transients are simulated; finally, the data has been analyzed in MATLAB software. The simulation results show that the proposed method is able to quickly and accurately distinguish internal faults from external faults and is not affected by transients.
Palliativmedizin – mehr als eine
Fachdisziplin?
Authors: Kloke Marianne 
Published: December 2022

ZusammenfassungDer Erörterung der besonderen Bedeutung von Palliativmedizin (PM)
für Patienten, die Medizin und die Gesellschaft wird die Frage nach der
Existenz eines eigenständigen Fachgebietes PM vorangestellt. In
Anwendung der von R. Stichweh beschriebenen Kriterien muss diese mit Ja
beantwortet werden. Die Spezifika von PM werden anhand ihres
gesamtgesellschaftlichen Anspruches und Selbstverständnisses sowie ihrer
medizin-ethischen Bedeutung aufgezeigt. Fazit: Die Reintegration des
PM-Gedankens in die gesamte Medizin kann erheblich zur Humanisierung sowohl der
Medizin als auch der Gesellschaft beitragen.
Psychische Gesundheit bei Kindern und Jugendlichen mit rheumatischen Erkrankungen
Authors: Sengler Claudia , Milatz Florian , Minden Kirsten 
Published: December 2022

ZUSAMMENFASSUNGKinder und Jugendliche mit chronischen rheumatischen Erkrankungen erleben oft vielfältige Belastungen, wie Schmerzen, Funktionsstörungen, Nebenwirkungen von Medikamenten, und sind nicht selten durch zeitintensive Therapien und Arztbesuche in ihrem sozialen Leben beeinträchtigt. So kann – trotz immer besserer Therapiemöglichkeiten – auch die psychische Gesundheit leiden. Verschiedene Forschungsverbünde (z. B. COACH) und Studien (z. B. KickCOVID) widmen sich zurzeit mittels spezifischer Fragebögen psychischen Symptomen von Kindern und Jugendlichen mit verschiedenen chronischen Erkrankungen (z. B. Mukoviszidose, juvenile idiopathische Arthritis, Typ-1-Diabetes). Psychische Komorbiditäten können im Kontext einer chronischen Erkrankung zu einer schlechteren Lebensqualität sowie zu einer geringeren Therapieadhärenz führen, welche wiederum das Outcome der Grunderkrankung beeinträchtigt. Eine umfassende Versorgung chronisch kranker junger Menschen sollte daher ein standardisiertes Screening auf psychische Komorbiditäten im Rahmen routinemäßiger Verlaufskontrollen beinhalten.
Sarkopenie als unabhängiger Prognosefaktor bei Pankreaskarzinom
Authors: Mandl Johanna , Baumer Sebastian , Holtzem Bernadette , Theurer Rainer , Zorger Niels , Pech Oliver 
Published: December 2022

Zusammenfassung
Einleitung Die Diagnose Pankreaskarzinom zählt trotz modernster Diagnose- und Therapieoptionen zu den häufigsten krebsbedingten globalen Todesursachen. Häufig liegt bei diesen Patienten eine Kachexie und Sarkopenie vor.
Methode In einer retrospektiven Analyse wurde die jeweilige Querschnittsfläche der Skelettmuskulatur auf Höhe des Lendenwirbelkörpers L 3 im axialen CT-Schnittbild von 121 Patienten bestimmt, um so den Skelettmuskelindex (SMI [cm2/m2]) zu erhalten. Es erfolgte außerdem eine Erfassung weiterer Parameter zur zusätzlichen Evaluation deren Assoziation mit der Überlebenswahrscheinlichkeit.
Ergebnisse Die durchschnittliche Überlebenszeit der Gruppe der sarkopenen Patienten war mit 14,4 Monaten im Vergleich zu 17,7 Monaten mittlerer Überlebenszeit bei Patienten ohne Sarkopenie signifikant vermindert (p=0,046). Zusätzlich konnten das Alter (p = 0,006), eine nicht erfolgte Resektion des Tumors (p=0,004), Metastasen bei Erstdiagnose (p=0,002) sowie ein erhöhtes CA 19–9 (p=0,002) als statistisch signifikante negative Prognosefaktoren identifiziert werden.
Schlussfolgerung Sarkopenie ist ein unabhängiger prognostischer Faktor in Bezug auf die Überlebenszeit bei Pankreaskarzinompatienten. Dies legt die standardmäßige Integration des SMI als Prognoseparameter in den klinischen Alltag nahe, um durch entsprechende präventive und therapeutische ernährungs- und bewegungsmedizinische Maßnahmen möglicherweise die Lebensdauer sowie die Lebensqualität von Pankreaskarzinompatienten merklich verbessern zu können.
Können Resilienz und Selbstwirksamkeit Therapieelemente in der Behandlung chronisch kranker Kinder und Jugendlicher sein?
Authors: Rohde Michelle , Mönkemöller Kirsten 
Published: December 2022

ZUSAMMENFASSUNGResilienz und Selbstwirksamkeit sind entscheidende Variablen im Therapieerfolg chronisch erkrankter Kinder und Jugendlicher. Resilienzförderliche Faktoren finden sich nicht nur bei der betroffenen Person selbst, sondern vor allem auch in ihrem Umfeld. Dabei sind verlässliche Bezugspersonen ebenso bedeutsam wie ressourcenorientierte Fachkräfte, um Betroffenen eine nach vorne gerichtete Entwicklung zu ermöglichen. Die vorliegende Arbeit zeigt, dass es sinnvoll sein kann, Patienten und ihre Familien auch im Rahmen der Therapie gezielt in der Bewältigung ihrer Erkrankung zu unterstützen und bei ihnen vorhandene Ressourcen zu stärken. Es werden daher Möglichkeiten aufgezeigt, wie resilienz- und selbstwirksamkeitssteigernde Elemente effizient in die Therapie von chronischen Erkrankungen im Kindes- und Jugendalter integriert werden könnten.
Diabetes und Schwangerschaft
Authors: Hummel Michael , Füchtenbusch Martin , Battefeld Wilgard , Bührer Christoph , Groten Tanja , Haak Thomas , Kainer Franz , Kautzky-Willer Alexandra , Lechner Andreas , Meissner Thomas , Nagel-Reuper Christine , Schäfer-Graf Ute , Siegmund Thorsten 
Published: December 2022

ZUSAMMENFASSUNGSchwangerschaften mit präkonzeptionell bekanntem Typ-1- und Typ-2-Diabetes sind Hochrisiko-Schwangerschaften und bedürfen einer interdisziplinären Betreuung. Kinder diabetischer Mütter haben ein im Mittel 1,5- bis 3-fach erhöhtes Risiko für angeborene Fehlbildungen, Frühgeburtlichkeit, Hypertrophie, Atemstörungen, Plexusparese und Asphyxie. Das Risiko für Totgeburt und Tod in den ersten 7 Lebenstagen ist bei prägravidem Diabetes erhöht. Die mit Abstand häufigste Komplikation bei Neugeborenen diabetischer Mütter ist die postnatale Hypoglykämie. Diabetesassoziierte Begleiterkrankungen und maternale Adipositas sind unabhängige Risikofaktoren für Schwangerschaftskomplikationen und ein ungünstiges fetales Outcome. Für die Blutglukoseeinstellung während der Schwangerschaft wurde ein klarer Zusammenhang höherer Werte mit ungünstigen fetalen und maternalen Ereignissen gezeigt. Analoginsuline sind mittlerweile die Insuline der Wahl. Darüber hinaus konnte eine Überlegenheit einer CGM-Versorgung während der Schwangerschaft gegenüber der konventionellen Blutglukosemessung gezeigt werden. Die Rate an Sektiones ist bei Frauen mit Diabetes nach wie vor gegenüber der Grundgesamtheit in der Perinatalstatistik deutlich erhöht. Evidenzbasierte Erkenntnisse zum intrapartalen Vorgehen liegen nicht vor. Die Einstellungsziele orientieren sich daher an den während der Schwangerschaft geltenden Zielen.
A Comparative Review of the Outcome Following MVD and PBC in Patients with Trigeminal Neuralgia
Authors: Zhou Yi , Dou Ning-Ning , Liu Xue-Lai , Wang Hui , Zhong Jun 
Published: December 2022

Abstract
Background This study aims to systematically review the treatment outcomes of percutaneous balloon compression (PBC) and microvascular decompression (MVD) in patients with trigeminal neuralgia.
Methods A systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guideline was performed using PubMed, Embase, and Cochrane Central Registry of Controlled Trials databases. Only those articles with more than 5 years' follow-up length were included in this investigation. To uniformly assess the postoperative outcome, we defined pain relief as totally pain free, while the postoperative hospitalization and last follow-up period were defined as early and long term, respectively. The facial numbness was quantified with Barrow Neurological Institute Pain Intensity Score (BNI).
Results After database searching and screening, 7,797 cases were finally included according to the criteria. The early pain relief rates were 94.1% (1,551/1,649) and 89.9% (4,962/5,482) following PBC and MVD (odds ratio [OR] = 0.603; p < 0.05), while the long-term rates were 58.1% (921/1,566) and 74.9% (4,549/6,074; OR = 2.089; p < 0.05), respectively. Although a significant higher facial numbness occurred in the PBC group in the early stage, it was mostly diminished 5 years later compared with the MVD group. At long-term follow-up, hypoacusis and facial palsy occurred more often in the MVD group (p < 0.05).
Conclusions Both MVD and PBC provide a satisfactory outcome for the patients in the long term. As a simple, safe, and reliable technique, PBC should be considered as a viable alternative.