bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sticking Together: Injectable Granular Hydrogels with Increased Functionality via Dynamic Covalent Inter‐Particle Crosslinking
Authors: Muir Victoria G. , Qazi Taimoor H. , Weintraub Shoshana , Torres Maldonado Bryan O. , Arratia Paulo E. , Burdick Jason A. 
Published: March 2022

AbstractGranular hydrogels are an exciting class of microporous and injectable biomaterials that are being explored for many biomedical applications, including regenerative medicine, 3D printing, and drug delivery. Granular hydrogels often possess low mechanical moduli and lack structural integrity due to weak physical interactions between microgels. This has been addressed through covalent inter‐particle crosslinking; however, covalent crosslinking often occurs through temporal enzymatic methods or photoinitiated reactions, which may limit injectability and material processing. To address this, a hyaluronic acid (HA) granular hydrogel is developed with dynamic covalent (hydrazone) inter‐particle crosslinks. Extrusion fragmentation is used to fabricate microgels from photocrosslinkable norbornene‐modified HA, additionally modified with either aldehyde or hydrazide groups. Aldehyde and hydrazide‐containing microgels are mixed and jammed to form adhesive granular hydrogels. These granular hydrogels possess enhanced mechanical integrity and shape stability over controls due to the covalent inter‐particle bonds, while maintaining injectability due to the dynamic hydrazone bonds. The adhesive granular hydrogels are applied to 3D printing, which allows the printing of structures that are stable without any further post‐processing. Additionally, the authors demonstrate that adhesive granular hydrogels allow for cell invasion in vitro. Overall, this work demonstrates the use of dynamic covalent inter‐particle crosslinking to enhance injectable granular hydrogels.
Anticipation of the compressive strength of steel fiber‐reinforced concrete by different types of artificial intelligence methods
Authors: Pazouki Gholamreza , Pourghorban Arash 
Published: March 2022

AbstractAlthough concrete is one of the most prevalent materials in the world, it has a main flaw that is fragility, and this flaw stands out especially in strain. One way for improving the fragility property of the concrete is to add the amount of steel fiber to the concrete mixture. Adding steel fiber to the concrete mixture will not only improve the brittleness of concrete but also enhance other mechanical properties including compressive strength (which is one of the most important properties of the concrete). Determining the compressive strength of steel fiber‐reinforced concrete (SFRC) is a costly and time‐consuming procedure and can have an impact on the environment. So, reliable alternative method(s) for determining the value of this property is needed. However, the development of a technique for predicting the compressive strength of SFRC is at an initial level in comparison with the normal concrete because of its complexity and limited available data. In this study, three artificial intelligence methods such as radial basis function neural network (RBFNN), artificial neural network, and adaptive‐neuro fuzzy inference system have been proposed for predicting the compressive strength of SFRC. In this regard, 230 data have been collected from previous studies for introduction to the models. In addition, the performance of the models was investigated by comparing the model's results with experimental data. Moreover, the statistical parameters have been used for assessing the performances of the models and comparing the ability and accuracy of the models with each other. In this study, the values of statistical parameters show that all three models have a good ability for predicting the compressive strength of SFRC, and the accuracies of the models are acceptable. Overall, based on the values of statistical parameters like the Pearson correlation coefficient (which is 0.97 for all data of the RBFNN model), and the amount of time required by the model to get the results, the RBFNN model has been considered as the best model for predicting the compressive strength of SFRC.
Perceptions, attitudes and practices regarding canine zoonotic helminthiases among dog owners in Nyagatare district, Rwanda
Authors: Ntampaka Pie , Niragire François , Nkurunziza Vincent , Uwizeyimana Gisele , Shyaka Anselme 
Published: March 2022

AbstractBackgroundDespite their importance to society, dogs are susceptible to various helminths. This study aimed to understand perceptions, attitudes and practices (PAP) regarding canine zoonotic helminthiases (CZH) among dog owners in Rwanda.MethodsA cross‐sectional study was carried out in Nyagatare district of Rwanda, where 203 dog owners were randomly selected and interviewed. To analyse this study's data, we used frequency distributions, chi‐square test of association and binary logistic regression model.ResultsOverall, 75.9% and 30% of the respondents were aware of canine and human helminthiases, respectively. Around 74.4% knew that dogs source helminthiases from eating raw infected meat. Also, 74.4% knew vomiting, diarrhoea and swelling of the belly as clinical signs of the helminthiases. Around 58.6% washed hands with soap and water after handling a dog. Only 17.2% and 15.5% dewormed the dogs and treated them against ectoparasites using conventional anthelmintics and acaricides manufactured for dogs, respectively. Of all respondents, 33% held genuine perceptions, while 78.3% and 25.1% adopted positive attitudes and appropriate practices about CZH, respectively. The respondents’ educational level and length of dog ownership correlated with their perceptions and practices about CZH, respectively, while sources of information on CZH influenced their PAP of such infections. The adjusted odds ratio (OR) of having genuine perceptions and positive attitudes were more than 82% lower among those who sourced the information from neighbours & colleagues compared to those who gathered it through reading. Again, the length of dog ownership (OR = 0.37, 95% CI: 0.15–0.90) correlated with the respondent's practices about CZH.ConclusionsOnly 33% and 25.1% of the respondents held genuine perceptions and adopted positive attitudes regarding CZH, respectively. The findings indicate increased zoonotic helminths in dogs, possible spillover in humans and anthelmintic resistance. Therefore, awareness campaigns are needed to upgrade dog owners’ knowledge of the zoonotic helminthiases in dogs in Nyagatare district.
Complete dominant inheritance of intracellular leucine accumulation traits in polyploid yeasts
Authors: Fukuda Nobuo , Takeuchi Mio 
Published: March 2022

AbstractThe yeast Saccharomyces cerevisiae is widely used for ethanol production. In the production of alcoholic beverages, flavours are affected mainly by yeast metabolism in the fermentation process. To increase the contents of initial scented fruity flavours, such as isoamyl alcohol and isoamyl acetate, leucine accumulation in yeast cells is induced by a decrease of leucine feedback inhibition in the l‐leucine synthetic pathway using conventional mutagenesis. Diploid strains are commonly used in sake brewing because of better fermentation performance, such as vitality and endurance, compared with those of haploid strains. Heterozygous mutations are mostly detected in target genes of brewing yeasts generated through mutation breeding. Here we describe that an allele of the LEU4 gene, LEU4G516S, dominantly induced leucine accumulation even in triploid and tetraploid yeasts as with in diploid yeasts. Importantly, we demonstrated that there is no difference in the intracellular amount of branched‐chain amino acids between LEU4G516S/LEU4 heterozygous diploids and LEU4G516S/LEU4G516S homozygous diploids. The approach to increase isoamyl alcohol and isoamyl acetate by intracellular leucine accumulation can potentially be applied to a variety of yeast strains, including aneuploid and polyploid yeasts.
Diasporic Viewing of Korean TV
Authors: Yoon Kyong 
Published: March 2022

AbstractThe young Korean Canadians’ diasporic viewing of Korean TV reveals how Hallyu media is integrated into viewers’ everyday contexts. In the midst of White-dominant media representation, the increasing global popularity of Korean TV may provide the diasporic youth with an option for exploring how they can critically navigate between different cultural texts and contexts. Narrative Hallyu media and its storytelling allow the young people to identify themselves with the distant (ancestral) homeland and furthermore to engage with non-Western storytelling and representation without self-monitoring and feelings of marginalization.
Conclusion: Diasporizing Hallyu
Authors: Yoon Kyong 
Published: March 2022

AbstractWhile Hallyu media itself may not be inherently counter-hegemonic, the diasporic audiences’ critical engagement with the Korean Wave may enhance transnational Korean media’s potential to challenge the dominant mediascape. The diasporic dimensions of Hallyu contribute to questioning the hegemonic forces that intensify the nationalistic and/or Westernizing processes of this transnational cultural trend. In response to the recent rise of Hallyu, diasporic young Korean Canadians engage with this cultural wave and negotiate different identity positions, associated with hereandthere.
Gymnasium und FMS als Zubringer zur Primarlehrpersonenbildung
Authors: Hafner Sandra 
Published: March 2022

ZusammenfassungDieses Kapitel beginnt mit einer kurzen Darstellung des Status quo der Ausbildung von Primarlehrpersonen in der Schweiz und den entsprechenden Zulassungsbedingungen. Anschließend folgt mit Blick auf die erste Fragestellung nach dem Institutionalisierungsprozess der FMS Pädagogik der aktuelle Stand der empirischen Forschung zur historischen Entwicklung der FMS und des Gymnasiums als Zugangswege zur tertiarisierten Lehrpersonenbildung. Danach werden die beiden untersuchten Profile – die FMS Pädagogik und das musisch-pädagogische Gymnasialprofil – in ihren Grundzügen erläutert und ein aktueller Forschungsüberblick präsentiert.
Methodologie, Forschungsdesign und Methoden
Authors: Hafner Sandra 
Published: March 2022

ZusammenfassungIm folgenden Kapitel wird ausgeführt, wie die Theorieperspektive der EC in dieser Studie methodologisch und forschungspraktisch umgesetzt wurde. Dazu wird die Auswahl und Beschaffenheit der empirischen Datenbasis sowie der zu untersuchenden Fälle und Erhebungseinheiten erläutert und vor dem Hintergrund der bisherigen empirischen Forschung sowie der Theorieperspektive der EC begründet. Es werden die zur Anwendung gekommenen methodischen Werkzeuge respektive Strategien der Datenerhebung und -analyse skizziert, begründet und ein Einblick in die konkrete Forschungspraxis gegeben.
Diskussion und Fazit
Authors: Hafner Sandra 
Published: March 2022

ZusammenfassungIn diesem Kapitel wird a) die historische Bedeutung der FMS Pädagogik und des musisch-pädagogischen Gymnasialprofils, b) ihre aktuelle quantitative Bedeutung sowie c) ihre Bedeutung aus einer qualitativen Perspektive im Rahmen der drei kantonalen Fallstudien zusammenfassend und mit Blick auf die formulierten Arbeitshypothesen präsentiert. Im Anschluss werden die Ergebnisse in bestehende empirische Forschung eingeordnet und der konventionentheoretische Rahmen der Studie reflektiert. Ebenso werden die Grenzen der Studie sowie ihre wissenschaftliche und praktische Relevanz diskutiert. Abschließend erfolgt ein Ausblick und die Formulierung weiterer Forschungsdesiderata.
Using Social Media in Open, Distance, and Digital Education
Authors: Bozkurt Aras 
Published: March 2022

AbstractThe technology used by Open, Distance, and Digital Education (ODDE) to deliver educational content includes social media (SM), which provides many opportunities to support learning in ODDE processes. This book chapter explains the use of SM in educational processes and the use of SM as a web-based educational technology, focusing specifically on the development of web technologies and SM from the perspective of ODDE. Furthermore, the chapter explores the affordances and limitations of SM through theoretical/conceptual lenses to better understand social media and its use in ODDE. In examining the research patterns on SM, four themes emerged, suggesting SM supports ODDE learning through: (1) social communication, interaction, and collaboration in online learning communities, (2) improved engagement, motivation, and satisfaction of learners, (3) functionality as an alternative learning management system for blended courses in higher education, and (4) facilitation of networked and connectivist informal learning. With its many social features, SM can be used to assist both formal and informal learning, but there still are some issues to resolve before ODDE can fully adopt it.
Off-equilibrium non-Gaussian fluctuations near the QCD critical point: an effective field theory perspective
Authors: Sogabe Noriyuki , Yin Yi 
Published: March 2022

Abstract
The non-Gaussian fluctuations of baryon density are sensitive to the presence of the conjectured QCD critical point. Their observational consequences are crucial for the ongoing experimental search for this critical point through the beam energy scan program at Relativistic Heavy Ion Collider (RHIC). In the expanding fireball created in a heavy-ion collision, critical fluctuations would inescapably fall out of equilibrium and require a systematic description within a dynamical framework. In this paper, we employ newly developed effective field theory (EFT) for fluctuating hydrodynamics to study the real-time critical non-Gaussian fluctuations of a conserved charge density. In particular, we derive the evolution equations for multi-point correlators of density fluctuations and obtain the closed-form solutions with arbitrary initial conditions that can readily be implemented in realistic simulations for heavy-ion collisions. We find that non-linear interactions among noise fields, which are missing in traditional stochastic hydrodynamics, could potentially contribute to the quartic (fourth-order) fluctuations in the scaling regime even at tree level in off-equilibrium situations.
Integrands of less-supersymmetric Yang-Mills at one loop
Authors: Bourjaily Jacob L. , Herrmann Enrico , Langer Cameron , Patatoukos Kokkimidis , Trnka Jaroslav , Zheng Minshan 
Published: March 2022

Abstract
We construct a prescriptive, bubble power-counting basis of one-loop integrands suitable for representing amplitude integrands in less-supersymmetric (1 ≤$$ \mathcal{N} $$
N
≤ 4) Yang-Mills theory. With the exception of massless bubbles, all integrands have unambiguous, leading singularities as coefficients defined in field theory; for the massless bubbles on external legs, we find two natural choices which lead to different integrands that highlight distinct aspects of field theory. For concreteness, we give the all-multiplicity integrands for MHV amplitudes, and the split-helicity amplitude integrand for six-particle NMHV. The basis we construct is mostly pure and is divided into to separately UV- and IR-finite sectors of fixed transcendental weight, resulting in UV- and IR-finite ratio functions of n-particle helicity amplitudes.
An Operator Product Expansion for Form Factors III. Finite Coupling and Multi-Particle Contributions
Authors: Sever Amit , Tumanov Alexander G. , Wilhelm Matthias 
Published: March 2022

Abstract
Form factors in planar 𝒩 = 4 super-Yang-Mills theory have a dual description in terms of periodic Wilson loops. This duality maps the multi-collinear expansion of the former to an operator product expansion of the latter. The coefficients of this expansion are decomposed in terms of several elementary building blocks and can be determined at finite ’t Hooft coupling using bootstrap and integrability techniques. Some of these building blocks are known from an analogous expansion of scattering amplitudes. In addition to these, the expansion for form factors includes a new type of building block, called form factor transitions, that encode information about the local operator. In the present paper, we consider the form factor of the chiral part of the stress-tensor supermultiplet. We bootstrap the corresponding form factor transitions of two-particle flux-tube states and use them to predict the leading term in the collinear expansion at finite coupling. The transitions we find can be expressed in terms of a quantity that previously appeared in a seemingly unrelated context, namely the octagon kernel. Lastly, we use a factorized ansatz to determine the multi-particle form factor transitions at finite coupling, which we use to predict the first subleading term in the collinear expansion. A perfect match is found between our predictions and the available perturbative data.
On-shell Higgsing for EFTs
Authors: Balkin Reuven , Durieux Gauthier , Kitahara Teppei , Shadmi Yael , Weiss Yaniv 
Published: March 2022

Abstract
We study the on-shell version of the Higgs mechanism in effective theories (EFTs) containing particles of different spins, focusing on contact terms as a simple starting point. We derive the massive contact terms and their coefficients from the massless amplitudes of the EFT above the symmetry breaking scale, by covariantizing the massless contact terms under the massive little group. In the little-group-covariant massive-spinor formalism, this notationally amounts to bolding spinor labels. Mass-suppressed contributions to the contact-term coefficients arise from higher-point contact terms with additional soft Higgs legs. We apply this procedure to obtain massive four-point amplitudes featuring scalars, spin 1/2 fermions and vectors, in the standard-model EFT. The subleading helicity-flipped components of each massive contact term, which are dictated by little-group covariance, are associated with the residues of factorizable massless amplitudes. Extra “frozen” Higgses emitted from each leg of a massless contact term supply the additional light-like momentum component, needed to form a massive leg of the same polarization. As another application, we derive various components of massive three-point amplitudes from massless amplitudes with up to three additional Higgses, in a standard-model-like toy model.
Characteristic classes for families of bundles
Authors: Berglund Alexander 
Published: March 2022

AbstractThe generalized Miller–Morita–Mumford classes of a manifold bundle with fiberMdepend only on the underlying$$\tau _M$$τM-fibration, meaning the family of vector bundles formed by the tangent bundles of the fibers. This motivates a closer study of the classifying space for$$\tau _M$$τM-fibrations,$$Baut(\tau _M)$$Baut(τM), and its cohomology ring, i.e., the ring of characteristic classes of$$\tau _M$$τM-fibrations. For a bundle$$\xi $$ξover a simply connected Poincaré duality space, we construct a relative Sullivan model for the universal$$\xi $$ξ-fibration with holonomy in a given connected monoid, together with explicit cocycle representatives for the characteristic classes of the canonical bundle over its total space. This yields tools for computing the rational cohomology ring of$$Baut(\xi )$$Baut(ξ)as well as the subring generated by the generalized Miller–Morita–Mumford classes. To illustrate, we carry out sample computations for spheres and complex projective spaces. We discuss applications to tautological rings of simply connected manifolds and to the problem of deciding whether a given$$\tau _M$$τM-fibration comes from a manifold bundle.
Twenty years of experience of a tertiary cancer center in total body irradiation with focus on oncological outcome and secondary malignancies
Authors: Sieker Katharina , Fleischmann Maximilian , Trommel Martin , Ramm Ulla , Licher Jörg , Bug Gesine , Martin Hans , Serve Hubert , Rödel Claus , Balermpas Panagiotis 
Published: March 2022

Abstract
Purpose
Total body irradiation (TBI) is a common part of the myelo- and immuno-ablative conditioning regimen prior to an allogeneic hematopoietic stem cell transplantation (allo-HSCT). Due to concerns regarding acute and long-term complications, there is currently a decline in otherwise successfully established TBI-based conditioning regimens. Here we present an analysis of patient and treatment data with focus on survival and long-term toxicity.

Methods
Patients with hematologic diseases who received TBI as part of their conditioning regimen prior to allo-HSCT at Frankfurt University Hospital between 1997 and 2015 were identified and retrospectively analyzed.

Results
In all, 285 patients with a median age of 45 years were identified. Median radiotherapy dose applied was 10.5 Gy. Overall survival at 1, 2, 5, and 10 years was 72.6, 64.6, 54.4, and 51.6%, respectively. Median follow-up of patients alive was 102 months. The cumulative incidence of secondary malignancies was 12.3% (n = 35), with hematologic malignancies and skin cancer predominating. A TBI dose ≥ 8 Gy resulted in significantly improved event-free (p = 0.030) and overall survival (p = 0.025), whereas a total dose ≤ 8 Gy and acute myeloid leukemia (AML) diagnosis were associated with significantly increased rates of secondary malignancies (p = 0.003, p = 0.048) in univariate analysis. No significant correlation was observed between impaired renal or pulmonary function and TBI dose.

Conclusion
TBI remains an effective and well-established treatment, associated with distinct late-toxicity. However, in the present study we cannot confirm a dose–response relationship in intermediate dose ranges. Survival, occurrence of secondary malignancies, and late toxicities appear to be subject to substantial confounding in this context.
Identification of PDXDC1 as a novel pleiotropic susceptibility locus shared between lumbar spine bone mineral density and birth weight
Authors: Song Yu-Qian , Hu Shi-Di , Lin Xu , Meng Xiang-He , Wang Xiao , Zhang Yin-Hua , Peng Cheng , Gong Rui , Xu Tao , Zhang Tong , Li Chen-Zhong , Pan Dao-Yan , Yang Jia-Yi , Greenbaum Jonathan , Shen Jie , Deng Hong-Wen 
Published: March 2022

Abstract
An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibility variants shared between these two traits. We detected 5 novel potential pleiotropic loci which are located at or near 7 different genes (NTAN1, PDXDC1, CACNA1G, JAG1, FAT1P1, CCDC170, ESR1), among which PDXDC1 and FAT1P1 have not previously been linked to these phenotypes. To partially validate the findings, we demonstrated that the expression of PDXDC1 was dramatically reduced in ovariectomized (OVX) mice in comparison with sham-operated (SHAM) mice in both the growth plate and trabecula bone. Furthermore, immunohistochemistry assay with serial sections showed that both osteoclasts and osteoblasts express PDXDC1, supporting its potential role in bone metabolism. In conclusion, our study provides insights into some shared genetic mechanisms for BMD and BW as well as a novel potential therapeutic target for the prevention of OP in the early stages of the disease development.

Key messages

We investigated pleiotropy-informed enrichment between LS BMD and BW.

We identified genetic variants related to both LS BMD and BW by utilizing a cFDR approach.

PDXDC1 is a novel pleiotropic gene which may be related to both LS BMD and BW.

Elevated expression of PDXDC1 is related to higher BMD and lower ratio n-6/n-3 PUFA indicating a bone protective effect of PDXDC1.