bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive surgical margin’s impact on short-term oncological prognosis after robot-assisted partial nephrectomy (MARGINS study: UroCCR no 96)
Authors: Morrone Arnoult , Bentellis Imad , Bernhard Jean-Christophe , Bensalah Karim , Champy Cécile , Bruyere Franck , Doumerc Nicolas , Olivier Jonathan , Audenet François , Parier Bastien , Brenier Martin , Long Jean-Alexandre , Nouhaud François-Xavier , Branger Nicolas , Lang Hervé , Charles Thomas , Xylinas Evanguelos , Waeckel Thibaut , Gomez Florie , Boissier Romain , Rouget Benjamin , Shaikh Aysha , Chevallier Daniel , Ambrosetti Damien , Durand Matthieu 
Published: October 2022

AbstractThe oncological impact of positive surgical margins (PSM) after robot-assisted partial nephrectomy (RAPN) is still under debate. We compared PSM and Negative Surgical Margins (NSM) in terms of recurrence-free survival (RFS), metastasis-free survival (MFS) and overall survival (OS) after RAPN, and we identified predictive factors of PSM. Multi-institutional study using the UroCCR database, which prospectively included 2166 RAPN between April 2010 and February 2021 (CNIL DR 2013-206; NCT03293563). Two groups were retrospectively compared: PSM versus NSM. Prognostic factors were assessed using Kaplan–Meyer curves with log-Rank test, cox hazard proportional risk model and logistic regression after univariate comparison. 136 patients had PSM (6.3%) and 2030 (93.7%) had NSM. During a median follow-up of 19 (9–36) months after RAPN, 160 (7.4%) recurrences were reported. Kaplan–Meier curves and analysis suggested that RFS, MFS and OS were not affected by a PSM (p = 0.68; 0.71; 0.88, respectively). In multivariate analysis predictors of PSM were a lower RENAL score (p = 0.001), longer warm ischemia time (WIT) (p = 0.003) and Chromophobe Renal Cell Carcinoma (chrRCC) (p = 0.043). This study found no impact of PSM on RFS, MFS or OS, and predictors of PSM were the RENAL score, WIT and chrRCC.
Prediction of textile pilling resistance using optical coherence tomography
Authors: Gocławski Jarosław , Sekulska-Nalewajko Joanna , Korzeniewska Ewa 
Published: October 2022

AbstractThis paper describes a new method of textile pilling prediction, based on multivariate analysis of the spatial layer above the surface. The original idea of the method is the acquisition of 3D fabric image using optical coherence tomography (OCT) with infrared light, which allows for the fabric fuzz visualization with high sensitivity. The pilling layer, reconstructed with the resolution of $$10\times 10\times 5.5 \; \upmu \mathrm {m}$$

10
×
10
×
5.5

μ
m

, includes reliable textural information related to the amount of loose fibers and bunches appearing as a result of abrasion. Pilling intensity was assigned by supervised classification of the textural features using both linear (PLS-DA - partial least squares discriminant analysis, LDA - linear discriminant analysis) and non-linear (SVM - support vector machine) classifiers. The results demonstrated that the method is more suitable for fabrics after short-term abrasion, when the fuzz prevails over tangled fibers in the pilling layer. In that case, pilling grades were predicted with $$>98\%$$

>
98
%

accuracy, sensitivity and specificity (for SVM model). The validation accuracy of the tested models after machine abrasion achieves lower values (up to $$90.4\%$$

90.4
%

for LDA model). With our method, we clearly showed that OCT can be used to quantitatively trace appearance changes of fabric samples due to test abrasion.
Mechanisms of prey division in striped marlin, a marine group hunting predator
Authors: Hansen M. J. , Krause S. , Dhellemmes F. , Pacher K. , Kurvers R. H. J. M. , Domenici P. , Krause J. 
Published: October 2022

AbstractMany terrestrial group-hunters cooperate to kill prey but then compete for their share with dominance being a strong predictor of prey division. In contrast, little is known about prey division in group-hunting marine predators that predominately attack small, evasive prey (e.g. fish schools). We identified individual striped marlin (Kajikia audax) hunting in groups. Groups surrounded prey but individuals took turns attacking. We found that competition for prey access led to an unequal division of prey among the predators, with 50% of the most frequently attacking marlin capturing 70–80% of the fish. Neither aggression, body size nor variation in hunting efficiency explained this skewed prey division. We did find that newly arrived groups of marlin gained on average more access to the prey. This raises the possibility that newly arrived marlin were hungrier and more motivated to feed. However, this result does not necessarily explain the unequal prey division among the predators because the skew in prey captures was found at the level of these groups. Dynamic prey division is probably widespread but under-reported in marine group-hunters and the inability of individuals to monopolize prey until satiation likely reduces the importance of social hierarchies for prey division.
A fast blind zero-shot denoiser
Authors: Lequyer Jason , Philip Reuben , Sharma Amit , Hsu Wen-Hsin , Pelletier Laurence 
Published: October 2022

AbstractImage noise is a common problem in light microscopy. This is particularly true in real-time live-cell imaging applications in which long-term cell viability necessitates low-light conditions. Modern denoisers are typically trained on a representative dataset, sometimes consisting of just unpaired noisy shots. However, when data are acquired in real time to track dynamic cellular processes, it is not always practical nor economical to generate these training sets. Recently, denoisers have emerged that allow us to denoise single images without a training set or knowledge about the underlying noise. But such methods are currently too slow to be integrated into imaging pipelines that require rapid, real-time hardware feedback. Here we present Noise2Fast, which can overcome these limitations. Noise2Fast uses a novel downsampling technique we refer to as ‘chequerboard downsampling’. This allows us to train on a discrete 4-image training set, while convergence can be monitored using the original noisy image. We show that Noise2Fast is faster than all similar methods with only a small drop in accuracy compared to the gold standard. We integrate Noise2Fast into real-time multi-modal imaging applications and demonstrate its broad applicability to diverse imaging and analysis pipelines.
National and subnational short-term forecasting of COVID-19 in Germany and Poland during early 2021
Authors: Bracher Johannes , Wolffram Daniel , Deuschel Jannik , Görgen Konstantin , Ketterer Jakob L. , Ullrich Alexander , Abbott Sam , Barbarossa Maria V. , Bertsimas Dimitris , Bhatia Sangeeta , Bodych Marcin , Bosse Nikos I. , Burgard Jan Pablo , Castro Lauren , Fairchild Geoffrey , Fiedler Jochen , Fuhrmann Jan , Funk Sebastian , Gambin Anna , Gogolewski Krzysztof , Heyder Stefan , Hotz Thomas , Kheifetz Yuri , Kirsten Holger , Krueger Tyll , Krymova Ekaterina , Leithäuser Neele , Li Michael L. , Meinke Jan H. , Miasojedow Błażej , Michaud Isaac J. , Mohring Jan , Nouvellet Pierre , Nowosielski Jedrzej M. , Ozanski Tomasz , Radwan Maciej , Rakowski Franciszek , Scholz Markus , Soni Saksham , Srivastava Ajitesh , Gneiting Tilmann , Schienle Melanie 
Published: October 2022

Abstract
Background
During the COVID-19 pandemic there has been a strong interest in forecasts of the short-term development of epidemiological indicators to inform decision makers. In this study we evaluate probabilistic real-time predictions of confirmed cases and deaths from COVID-19 in Germany and Poland for the period from January through April 2021.

Methods
We evaluate probabilistic real-time predictions of confirmed cases and deaths from COVID-19 in Germany and Poland. These were issued by 15 different forecasting models, run by independent research teams. Moreover, we study the performance of combined ensemble forecasts. Evaluation of probabilistic forecasts is based on proper scoring rules, along with interval coverage proportions to assess calibration. The presented work is part of a pre-registered evaluation study.

Results
We find that many, though not all, models outperform a simple baseline model up to four weeks ahead for the considered targets. Ensemble methods show very good relative performance. The addressed time period is characterized by rather stable non-pharmaceutical interventions in both countries, making short-term predictions more straightforward than in previous periods. However, major trend changes in reported cases, like the rebound in cases due to the rise of the B.1.1.7 (Alpha) variant in March 2021, prove challenging to predict.

Conclusions
Multi-model approaches can help to improve the performance of epidemiological forecasts. However, while death numbers can be predicted with some success based on current case and hospitalization data, predictability of case numbers remains low beyond quite short time horizons. Additional data sources including sequencing and mobility data, which were not extensively used in the present study, may help to improve performance.
Family and Caregiver Characteristics Contribute to Caregiver Change in Use of Strategies and Growth in Child Spoken Language in a Parent-Implemented Language Intervention in Fragile X Syndrome
Authors: Potter Sarah Nelson , Bullard Lauren , Banasik Amy , Tempero Feigles Robyn , Nguyen Vivian , McDuffie Andrea , Thurman Angela John , Hagerman Randi , Abbeduto Leonard 
Published: October 2022

Purpose:
This study examined relationships among family characteristics, caregiver change in use of strategies, and child growth in spoken language over the course of a parent-implemented language intervention (PILI) that was developed to address some of the challenges associated with the fragile X syndrome (FXS) phenotype.

Method:
Participants were 43 parent–child dyads from two different PILI studies, both of which taught parents various language facilitation strategies to support child language. Before starting the intervention, parents reported on their mental health, parenting stress, and parenting competence. This study focused on potential barriers to treatment gains by examining correlations between the measures of parent well-being and (a) parent change in use of intervention strategies taught in the PILI and (b) changes in child language outcomes from pre- to post-intervention.

Results:
Parents in this study had elevated mental health symptoms across several domains and increased rates of parenting stress. Furthermore, although PILI resulted in treatment gains for both parents and children, a variety of parent mental health symptoms were found to be significantly and negatively associated with change in use of strategies and growth in child language over the course of the intervention. Some inconsistent findings also emerged regarding the relationships between parenting stress and competence and change in parent strategy use and growth in child language.

Conclusions:
This study provides preliminary evidence that parents who are experiencing significant mental health challenges may have a more difficult time participating fully in PILIs and that there may be subsequent effects on child outcomes. Future PILIs could benefit from addressing parent well-being as a substantial part of the intervention program.
E-Learning Fatigue and the Cognitive, Educational, and Emotional Impacts on Communication Sciences and Disorders Students During COVID-19
Authors: Reed Hope C. 
Published: October 2022

Purpose:
The purpose of this study was to investigate e-learning fatigue; the cognitive, educational, and emotional impacts on university students; and attitudes toward different course delivery modes after more than a year of COVID-19–mandated distance education in the United States.

Method:
A survey consisting of 25 Likert items was conducted with a total of 50 graduate and undergraduate students, mostly women between the ages of 18 and 45 years, majoring in communication sciences and disorders (CSD) at a Historically Black College/University (HBCU).

Results:
Younger, undergraduate, and Black/African American students reported being most unfavorably impacted by the e-learning requirements of COVID-19. Students without a prior history of online and hybrid learning also reported unfavorable effects, but not as consistently. Participants reporting higher levels of e-learning fatigue noted the greatest difficulties across all major areas of the study: learning, mental health, and attitudes toward e-learning. Higher e-learning fatigue was correlated with a higher negative impact on perceptions of future clinical effectiveness.

Conclusions:
Results show e-learning fatigue and the educational and emotional challenges of mandated e-learning during COVID-19 disproportionately affected certain groups of students, and they reported unfavorable views of e-learning and future clinical ability. This is the first study to examine how CSD students were affected by required distance learning during the pandemic. Future investigations may examine the long-term effects of the pandemic on students and their clinical skills, groups most susceptible to the negative impacts of e-learning, and ways to mitigate these effects to improve students' educational experiences and emotional well-being.
Study of Yang's Onion Flap Technique for Release of Scarred Eponychium and Nail Fold Reconstruction in Burn Patients
Authors: Srivastava Vaishali , Sharma Upendra , Rathore Deepak 
Published: October 2022

Abstract
Background Abnormalities of fingernail growth and appearance are among the most common deformities encountered after burn injury to the hand. Various techniques used for resurfacing defects include incision of the scarred eponychium and advancement of the distal segment, flap reconstruction-distally, and proximally based transposition/advancement flaps, composite graft techniques, microvascular transfer. In the present study, we used an onion flap to release scarred eponychium and nail fold reconstruction in a single stage without using soft tissue from another area.
Materials and methods Forty-four burnt fingers were operated using Yang's onion flap technique. Patients were assessed for flap necrosis, hematoma and infection in the early postoperative period and for donor site scar, nail appearance, and symptomatic relief in a follow-up for at least 4 months.
Results The flap was successfully performed on all fingers. Only two fingers had flap necrosis. There was no incidence of hematoma or infection. The donor site scar and nail plate appearance improved and was acceptable to most patients after surgery. There was also significant relief in daily activities in 19 out of 28 symptomatic patients.
Conclusion Yang's flap to correct nail deformities in burn patients is feasible in Indian scenario. It is associated with a low complication rate and improved nail appearance. There is also significant symptomatic relief in performing daily activities after surgery.
Reviving keV sterile neutrino dark matter
Authors: Jaramillo Carlos 
Published: October 2022

AbstractWe propose a new production mechanism for keV sterile neutrino dark matter which relies neither on the oscillations between sterile and active neutrinos nor on the decay of additional heavier particles. The dark matter neutrinos are instead produced by thermal freeze-out, much like a typical WIMP. The challenge consists in balancing a large Yukawa coupling so that the sterile neutrinos thermalize in the early universe on the one hand, and a small enough Yukawa coupling such that they are stable on cosmological scales on the other. We solve this problem by implementing varying Yukawa couplings. We achieve this by using a three-sterile neutrino seesaw extension to the SM and embedding it in a Froggatt-Nielsen model with a single flavon. Because the vev of the flavon changes during the electroweak phase transition, the effective Yukawa couplings of the fermions have different values before and after the phase transition, thus allowing for successful dark matter genesis. Additionally, the hierarchy in the flavour structure is alleviated and the origin of the light neutrino masses is explained by the interplay of the seesaw and Froggatt-Nielsen mechanisms.
Irrigation can create new green bridges that promote rapid intercontinental spread of the wheat stem rust pathogen
Authors: Bradshaw Catherine D , Thurston William , Hodson David , Mona Tamás , Smith Jacob W , Millington Sarah C , Blasch Gerald , Alemayehu Yoseph , Gutu Kitessa , Hort Matthew C , Gilligan Christopher A 
Published: October 2022

Abstract
Wheat stem rust epidemics caused by the obligate pathogenic fungus Puccinia graminis f.sp. tritici have historically driven severe yield losses on all wheat growing continents and, after many decades of control, stem rust is re-emerging as a disease of concern. In 1998, a highly virulent race able to overcome 90% of world wheat cultivars, Ug99, was identified in Uganda. Since initial detection, the pathogen has evolved many new variants and spread to many countries. The original variant spread from East Africa to the Middle East with three years between detection in Ethiopia and subsequent detection in Yemen. In 2014, another Ug99 variant (TTKTT), with one of the most complex virulence profiles, was detected in Kenya. This variant also spread from East Africa to the Middle East, but with only one year between detection in Ethiopia and subsequent detection in Iraq. Here we investigate potential airborne migration routes to account for the rapid spread of TTKTT in East Africa and beyond to the Middle East by using an integrated model combining the outputs from a meteorology-driven fungal spore dispersion model with epidemiological models to account for seasonal availability of susceptible crops and conditions for spore release and infectivity. We find viable pathways in the 2018/19 season that incorporate critical stepping-stone locations in Yemen or Saudi Arabia, but only in the presence of newly irrigated regions in Ethiopia. Our results indicate the potential and increasing importance of irrigated wheat areas in Ethiopia, Yemen and Saudi Arabia for inter-regional stem rust movements. Future movement of stem rust races out of East Africa is considered likely as irrigated areas expand. Targeted surveillance and the use of mitigation strategies including the use of durable resistant varieties in regions of irrigation are required to reduce the risks of enhanced dispersal of stem rust to other regions.
An effective algorithm for deciding the solvability of a system of polynomial equations over 𝑝-adic integers
Authors: Chistov A. 
Published: October 2022

Consider a system of polynomial equations in

n
n

variables of degrees at most

d
d

with integer coefficients whose lengths are at most

M
M

. By using a construction close to smooth stratification of algebraic varieties, it is shown that one can construct a positive integer

Δ
>

2

M
(
n
d

)

c

2
n

n
3

\begin{equation*} \Delta > 2^{M(nd)^{c\, 2^n n^3}} \end{equation*}

(here

c
>
0

c>0

is a constant) depending on these polynomials and having the following property. For every prime

p
p

the system under study has a solution in the ring of

p
p

-adic numbers if and only if it has a solution modulo

p
N

p^N

for the least integer

N
N

such that

p
N

p^N

does not divide

Δ
\Delta

. This improves the previously known, at present classical result by B. J. Birch and K. McCann.
Does polypharmacy shape dependency transitions in the very old? Findings from the Newcastle 85+ Study
Authors: Davies Laurie E , Todd Adam , Robinson Louise , Kingston Andrew 
Published: October 2022

Abstract

Background
helping older people to maintain their independence, and identifying risk factors that compromise this, is of high importance. Polypharmacy is common in the very old (aged ≥ 85) but whether it can shape transitions in dependency in this fastest growing subpopulation is unclear.

Methods
using Newcastle 85+ Study data and multi-state modelling, we investigated the association between each additional medication prescribed and the progression of and recovery from dependency states, over 10 years (age 85–95). Participants were defined as either free from care (independent), requiring care less often than daily (low dependency), or requiring care at regular intervals each day or 24 hourly (medium/high dependency).

Results
each additional medication prescribed was associated with a 10% decreased chance of recovery from low dependence to independence (hazard ratio (HR): 0.90, 95% confidence interval (CI): 0.82–0.99).

Discussion
when a relatively able person visits the GP or clinical pharmacist, careful consideration should be given to whether the potential benefits from adding a new medication outweigh the risk to reduced recovery of independence.
Baseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A Post Hoc Analysis of MESA
Authors: Wong Ka-Ho , Muddasani Varsha , Peterson Cecilia , Sheibani Nazanin , Arkin Cameron , Cheong Irene , Majersik Jennifer J , Biffi Alessandro , Petersen Nils , Falcone Guido J , Sansing Lauren H , de Havenon Adam H 
Published: October 2022

Abstract

Background
Higher blood pressure variability (BPV) is associated with the development of major vascular diseases, independent of mean blood pressure. However, despite data indicating that serum inflammatory markers are linked to hypertension, the association between serum inflammatory markers and BPV has not been studied in humans.

Methods
This is a post hoc analysis of the Multi-Ethnic Study of Atherosclerosis (MESA) study. The study exposure was tertiles of serum level of interleukin-6 (IL-6), C-reactive protein (CRP), d-dimer, plasmin–antiplasmin complex (PAP), fibrinogen antigen, and calibrated Factor VIII (%) at the baseline study visit. The primary outcome was visit-to-visit BPV measured as the residual standard deviation (rSD) of at least 4 study visits (2000–2018). Two logistic regression models were fit to the top tertile of rSD during follow-up: in Model 1, we adjusted for age, sex, and hypertension, and in Model 2, for patient age categories, sex, race/ethnicity, education, hypertension, diabetes, smoking, drinking, body mass index, lipid-lowering medication, and mean systolic blood pressure.

Results
Our analysis included 5,483 patients, with a mean (SD) age of 61.4 (10.0) years, 52.9% female, and 40.7% White. In unadjusted analyses, all markers of inflammation were associated with higher BPV, but after adjustment, only IL-6 retained significance (P &lt; 0.001). The odds ratio for the highest tertile of BPV and IL-6 was 1.49 (95% confidence interval [CI] 1.28–1.74, P &lt; 0.001).

Conclusions
Baseline serum IL-6 was associated with increased subsequent BPV in a large multiracial cohort. Further investigation is needed to better understand the relationship between chronic inflammation and BPV.