bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in volatile aroma profiles of soybean, rice, and wheatkojiduring fermentation using stir bar sorptive extraction followed by gas chromatography‐mass spectrometry and descriptive sensory analysis
Authors: Hwang In‐Seo , Kim Mina K. 
Published: November 2022

AbstractDoenjang, a fermented soybean paste, is a traditional food ingredient in Korea. While the flavor ofdoenjangis heavily dependent onkoji, studies on the aroma characteristics ofkojiremain limited. This study aimed to determine the changes in the aroma profiles of soybeankoji(SBK), ricekoji(RK), and wheatkoji(WK). Aroma analysis was performed using stir bar sorptive extraction followed by gas chromatography‐mass spectrometry (GC‐MS) and descriptive sensory analysis. In SBK, bean‐associated aroma was strongly developed due to the lipid‐derived compounds, whereas in RK, sweet aromas were relatively strong at 72 h due to the sweet‐smelling ester compounds. In WK, the nutty cracker attribute was significantly strengthened during fermentation due to the high concentration of aldehydes. The results showed that the aroma profile ofkojiwas influenced by main ingredient, and this finding is useful in improving aroma development with the use ofkojiin the fermented food industry.Practical ApplicationKojiis one of the key ingredients utilized in commercializeddoenjangmaking process in Korea, in order to accelerate the fermentation process. In this study, influences of raw materials ofkojiin the aroma development ofdoenjangwere investigated using descriptive sensory analysis and instrumental flavor analysis using GC‐MS. Raw material‐driven aroma compounds were documented in differentkojisamples, in which influences the aroma characteristics ofdoenjangmade withkojimade with different raw materials. Finding from this study can aiddoenjangmanufacturers for versatile aroma development of commercializeddoenjang.
Sleep disordered breathing and haemoglobin A1c levels within or over normal range and ageing or sex differences: the Nagahama study
Authors: Matsumoto Takeshi , Murase Kimihiko , Tabara Yasuharu , Minami Takuma , Kanai Osamu , Takeyama Hirofumi , Sunadome Hironobu , Nagasaki Tadao , Takahashi Naomi , Nakatsuka Yoshinari , Hamada Satoshi , Handa Tomohiro , Tanizawa Kiminobu , Nakamoto Isuzu , Wakamura Tomoko , Komenami Naoko , Setoh Kazuya , Kawaguchi Takahisa , Tsutsumi Takanobu , Morita Satoshi , Takahashi Yoshimitsu , Nakayama Takeo , Sato Susumu , Hirai Toyohiro , Matsuda Fumihiko , Chin Kazuo 
Published: November 2022

SummaryRecently an association between blood glucose dysregulation and sleep disruption was suggested. The association between sleep disordered breathing, most of which is due to obstructive sleep apnea (OSA) in the general population, and diabetic severity, as well as the impact of antidiabetic treatment, remains unclear. This study aimed to investigate these associations as well as age and sex differences. This cross‐sectional study evaluated 7,680 community participants as the main cohort (population‐based cohort). OSA was assessed by the 3% oxygen desaturation index from pulse oximetry, which was corrected for sleep duration obtained by wrist actigraphy. For arguing the limitations for using pulse oximetry, 597 hospitalised patients, who were assessed by the apnea–hypopnea index from attended polysomnography, were also evaluated as the validation cohort (hospital‐based cohort). Moderate‐to‐severe OSA was more prevalent as haemoglobin A1c (HbA1c) levels increased (<5.6%/5.6%–<6.5%/6.5%–<7.5%/≥7.5%, respectively) in both cohorts (p < 0.001), but only in those without antidiabetic treatment. The HbA1c level was an independent factor for moderate‐to‐severe OSA (population‐based cohort, odds ratio [OR] 1.26, 95% confidence interval [CI] 1.10–1.45; hospital‐based cohort, OR 1.69, 95% CI 1.22–2.33, per 1% increase). These associations were more prominent in the middle‐aged (aged <60 years) than in the elderly (aged ≥60 years) and in women than in men in both cohorts. The prevalence of moderate‐to‐severe OSA in patients with antidiabetic treatment in the hospital‐based cohort was ≥75% regardless of HbA1c levels. In conclusion, an association between the prevalence of OSA and HbA1c level even within or over the normal range was found only in patients without antidiabetic treatment and was more prominent in the middle‐aged and in women.
A core microbiome in the hyphosphere of arbuscular mycorrhizal fungi has functional significance in organic phosphorus mineralization
Authors: Wang Letian , Zhang Lin , George Timothy S. , Feng Gu 
Published: November 2022

Summary

The mycorrhizal pathway is an important phosphorus (P) uptake pathway for more than two‐thirds of land plants. The arbuscular mycorrhizal (AM) fungi‐associated hyphosphere microbiome has been considered as the second genome of mycorrhizal P uptake pathway and functionality in mobilizing soil organic P (Po). However, whether there is a core microbiome in the hyphosphere and how this is implicated in mining soil Po are less understood.

We established on‐site field trials located in humid, semiarid, and arid zones and a microcosm experiment in a glasshouse with specific AM fungi and varying soil types to answer the above questions.

The hyphosphere microbiome of AM fungi enhanced soil phosphatase activity and promoted Po mineralization in all sites. Although the assemblage of hyphosphere microbiomes identified in three climate zones was mediated by environmental factors, we detected a core set in three sites and the subsequent microcosm experiment. The core members were co‐enriched in the hyphosphere and dominated by Alphaproteobacteria, Actinobacteria, and Gammaproteobacteria. Moreover, these core bacterial members aggregate into stable guilds that contributed to phosphatase activity.

The core hyphosphere microbiome is taxonomically conserved and provides functions, with respect to the mineralization of Po, that AM fungi lack.
(−)‐Loliolide is a general signal of plant stress that activates jasmonate‐related responses
Authors: Li Lei‐Lei , Li Zheng , Lou Yonggen , Meiners Scott J. , Kong Chui‐Hua 
Published: November 2022

Summary
The production of defensive metabolites in plants can be induced by signaling chemicals released by neighboring plants. Induction is mainly known from volatile aboveground signals, with belowground signals and their underlying mechanisms largely unknown.
We demonstrate that (−)‐loliolide triggers defensive metabolite responses to competitors, herbivores, and pathogens in seven plant species. We further explore the transcriptional responses of defensive pathways to verify the signaling role of (−)‐loliolide in wheat and rice models with well‐known defensive metabolites and gene systems.
In response to biotic and abiotic stressors, (−)‐loliolide is produced and secreted by roots. This, in turn, induces the production of defensive compounds including phenolic acids, flavonoids, terpenoids, alkaloids, benzoxazinoids, and cyanogenic glycosides, regardless of plant species. (−)‐Loliolide also triggers the expression of defense‐related genes, accompanied by an increase in the concentration of jasmonic acid and hydrogen peroxide (H2O2). Transcriptome profiling and inhibitor incubation indicate that (−)‐loliolide‐induced defense responses are regulated through pathways mediated by jasmonic acid, H2O2, and Ca 2+.
These findings argue that (−)‐loliolide functions as a common belowground signal mediating chemical defense in plants. Such perception‐dependent plant chemical defenses will yield critical insights into belowground signaling interactions.
Characterization and allelism of soybean mosaic virus strain SC3 resistance in ‘Qihuang‐1’ derived soybean cultivars
Authors: Chen Shanyu , Liu Mengzhuo , Jin Tongtong , Wang Liqun , Xu Ran , Karthikeyan Adhimoolam , Zheng Guijie , Zhi Haijian 
Published: November 2022

AbstractSoybean mosaic virus is a severe constraint of soybean production in China. A total of country‐wide 22 SMV strains (SC1‐SC22) were identified. Of these, SC3 is a major strain widely distributed in Huanghuai and Yangtze River Valley region of China. Soybean cultivar ‘Qihuang‐1’ contains RSC3Q locus conditioning the resistance to SC3 and is an important parental line extensively used to breed the soybean cultivars in China. The objective of this study was to elucidate the genetic pattern of SC3 resistance genes in cultivars developed from ‘Qihuang‐1’ or its derivative lines. Hence, we have evaluated the SC3 resistance in 91 cultivars developed from ‘Qihuang‐1’ or its derivative lines. The results showed that a total of 43 cultivars exhibited resistance to the SC3 strain. Among them, 37 cultivars were derived from ‘Qihuang‐1’. Then, we have detected the RSC3Q loci in these cultivars using four SSR markers (Satt334, Sct_033, BARCSOYSSR_13_1114 and BARCSOYSSR_13_1136). It revealed that, among the 37 resistant cultivars derived from ‘Qihuang‐1’, there are 20 cultivars containing RSC3Q loci. Moreover, the allelic relationship of resistance genes was analysed using the crosses from resistance × resistance between ‘Qihuang‐1’ and its resistant derived cultivars. The results showed that the resistance genes of ‘Qihuang‐1’ and its 20 cultivars were allelic. But it is not allelic with those of the other 17 cultivars, different from ‘Qihuang‐1’, and also, RSC3Q does not condition the resistance. These results will be beneficial to exploring the transmission of resistance genes of ‘Qihuang‐1’ and will be useful to the disease resistance breeding of soybean.
Bilateral eyelid swelling as the presenting sign of subcutaneous sarcoidosis
Authors: McKinnon Alyson T. , Shalin Sara C. , Evans Megan S. 
Published: November 2022

AbstractAn 18‐year‐old Black female presented with a 2‐year history of bilateral upper eyelid swelling and the recent onset of multiple subcutaneous nodules on the arms. She had previously undergone evaluation and treatment for presumed angioedema. Biopsies of the eyelid and an arm nodule demonstrated non‐necrotizing granulomatous inflammation with special stains negative for acid‐fast bacilli and fungi, and the patient was diagnosed with subcutaneous sarcoidosis. The isolated finding of bilateral eyelid swelling 2 years prior to the onset of additional cutaneous findings led to a significant delay in diagnosis, highlighting the importance of considering sarcoidosis in the differential diagnosis for bilateral eyelid swelling.
Incidence and distribution of Botryosphaeriaceae species associated with dieback in walnut orchards in Australia
Authors: Antony Stella , Billones‐Baaijens Regina , Stodart Benjamin J. , Steel Christopher C. , Lang Michael D. , Savocchia Sandra 
Published: November 2022

AbstractFungi belonging to the family Botryosphaeriaceae have been implicated in significant economic loss in many horticultural crops worldwide. These fungal pathogens pose an emerging risk to the productivity of the Australian walnut industry, although which species of Botryosphaeriaceae are present is unknown. To address this knowledge gap, walnut tissues were collected from 14 orchards representing the major walnut‐growing regions of Australia, and fungal isolations performed. Botryosphaeriaceae species were recovered from both symptomatic and asymptomatic samples from nine of the orchards. DNA sequencing confirmed the presence of five Botryosphaeriaceae species, namely Diplodia seriata, Dothiorella omnivora, Neofusicoccum parvum, N. macroclavatum and Spencermartinsia viticola. Of the 106 Botryosphaeriaceae isolates recovered, D. seriata and N. parvum were the most prevalent species. Pathogenicity studies using detached stems indicated that Neofusicoccum spp. were the most virulent followed by D. seriata. This is the first systematic study on the incidence, identification and pathogenicity of species of Botryosphaeriaceae from walnut orchards in Australia.
The rise of GCC‐East Asian trade: A cointegration approach to analysing trade relationships
Authors: Rutledge Emilie , Polyzos Efstathios 
Published: November 2022

AbstractThe economic relationship between the Gulf Cooperation Council states and the countries of East Asia has grown in significance in recent years at the expense of the European Union and the USA. Empirical analysis of GCC‐East Asian trade indices shows that East Asian states now dominate GCC trade flows and a number of GCC‐East Asian Free Trade Agreements are cementing the long‐term economic ties between the two regional blocs, which are based on the complementarity of their economic structures and comparative advantage. Within East Asia, Japan is increasingly having to compete with China and India for both security of energy supplies from the GCC and to supply GCC markets with their manufactured exports. Using a new approach to analysing trade relationships, we utilise cointegration techniques to analyse GCC trade patterns over time. We find econometric evidence of a long‐term trade relationship between the GCC states and those of East Asia, in particular China, whose continued economic growth has allowed the GCC bloc to diversify its economic and political dependence away from North America and ‘look East’ for new strategic alliances.
Special issue on world Englishes and English for specific purposes (ESP)
Authors: Bolton Kingsley , Jenks Christopher 
Published: November 2022

AbstractThis special issue brings together leading scholars in the field of English for specific purposes (ESP) for an innovative and insightful discussion of the interface between ESP, as a leading subject area in applied and educational linguistics, and world Englishes (WE), as a sub‐discipline of linguistics and sociolinguistics. The contributions to this special issue explore, in various ways, the synergies between these two approaches for linguistic research and pedagogy.
World Englishes and English for specific purposes (ESP)
Authors: Bolton Kingsley , Jenks Christopher 
Published: November 2022

AbstractThis article sets out to review English for specific purposes (ESP) as a discipline and its conceptual and scholarly connections with the world Englishes (WE) approach English worldwide. This is done partly through a detailed literature review of articles on ESP in the Asian and European regions, taken from the journal English for Specific Purposes, identifying which countries and topics are most frequently represented in this leading publication. The later sections of the article go on to explore the disciplinary interface between ESP and world Englishes, with reference to the potential contributions of both disciplines to research on areas of shared interest, including English‐medium instruction (EMI) worldwide.
Is the Future Hazy?
Authors: Goudarzi Sara 
Published: November 2022

Abstract
Direct, large-scale solar management interventions have been part of the fringe of the climate debate for decades. To critics, they were seen as a speculative excuse for not doing the hard work of reducing carbon emissions. It was thought that even asking whether these interventions could be considered created a moral hazard. But the argument that the sole focus should be on greenhouse gas emissions has run into the reality that reduction has been too slow. Is it time to reconsider climate interventions?
Two new species of Steneotarsonemus (Acari: Tarsonemidae) from the Himalayan forests of West Bengal, India
Authors: Ganguly Moumi , Karmakar Krishna 
Published: November 2022

Two new species of the genus Steneotarsonemus Beer, 1954 namely Steneotarsonemus kharukiae Karmakar & Ganguly sp. nov. and Steneotarsonemus mohanasundarami Karmakar & Ganguly sp. nov. are described based on the specimens collected from northern hill zone of West Bengal. Steneotarsonemus kharukiae was collected from Capioedium assimile and closely resembles S. comosus and S. vasiljevae. Steneotarsonemus mohanasundarami was collected from Oplismenus sp. and closely resembles S. stipa and S. hippodromus.
Retracted papers originating from paper mills: cross sectional study
Authors: Candal-Pedreira Cristina , Ross Joseph S , Ruano-Ravina Alberto , Egilman David S , Fernández Esteve , Pérez-Ríos Mónica 
Published: November 2022

Abstract

Objectives
To describe retracted papers originating from paper mills, including their characteristics, visibility, and impact over time, and the journals in which they were published.

Design
Cross sectional study.

Setting
The Retraction Watch database was used for identification of retracted papers from paper mills, Web of Science was used for the total number of published papers, and data from Journal Citation Reports were collected to show characteristics of journals.

Participants
All paper mill papers retracted from 1 January 2004 to 26 June 2022 were included in the study. Papers bearing an expression of concern were excluded.

Main outcome measures
Descriptive statistics were used to characterise the sample and analyse the trend of retracted paper mill papers over time, and to analyse their impact and visibility by reference to the number of citations received.

Results
1182 retracted paper mill papers were identified. The publication of the first paper mill paper was in 2004 and the first retraction was in 2016; by 2021, paper mill retractions accounted for 772 (21.8%) of the 3544 total retractions. Overall, retracted paper mill papers were mostly published in journals of the second highest Journal Citation Reports quartile for impact factor (n=529 (44.8%)) and listed four to six authors (n=602 (50.9%)). Of the 1182 papers, almost all listed authors of 1143 (96.8%) paper mill retractions came from Chinese institutions and 909 (76.9%) listed a hospital as a primary affiliation. 15 journals accounted for 812 (68.7%) of 1182 paper mill retractions, with one journal accounting for 166 (14.0%). Nearly all (n=1083, 93.8%) paper mill retractions had received at least one citation since publication, with a median of 11 (interquartile range 5-22) citations received.

Conclusions
Papers retracted originating from paper mills are increasing in frequency, posing a problem for the research community. Retracted paper mill papers most commonly originated from China and were published in a small number of journals. Nevertheless, detected paper mill papers might be substantially different from those that are not detected. New mechanisms are needed to identify and avoid this relatively new type of misconduct.
Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis
Authors: Roelands Jessica , van der Ploeg Manon , Ijsselsteijn Marieke E , Dang Hao , Boonstra Jurjen J , Hardwick James C H , Hawinkels Lukas J A C , Morreau Hans , de Miranda Noel F C C 
Published: November 2022

ObjectiveBiological insights into the stepwise development and progression of colorectal cancer (CRC) are imperative to develop tailored approaches for early detection and optimal clinical management of this disease. Here, we aimed to dissect the transcriptional and immunologic alterations that accompany malignant transformation in CRC and to identify clinically relevant biomarkers through spatial profiling of pT1 CRC samples.DesignWe employed digital spatial profiling (GeoMx) on eight pT1 CRCs to study gene expression in the epithelial and stromal segments across regions of distinct histology, including normal mucosa, low-grade and high-grade dysplasia and cancer. Consecutive histology sections were profiled by imaging mass cytometry to reveal immune contextures. Finally, publicly available single-cell RNA-sequencing data was analysed to determine the cellular origin of relevant transcripts.ResultsComparison of gene expression between regions within pT1 CRC samples identified differentially expressed genes in the epithelium (n=1394 genes) and the stromal segments (n=1145 genes) across distinct histologies. Pathway analysis identified an early onset of inflammatory responses during malignant transformation, typified by upregulation of gene signatures such as innate immune sensing. We detected increased infiltration of myeloid cells and a shift in macrophage populations from pro-inflammatory HLA-DR+CD204−macrophages to HLA-DR−CD204+immune-suppressive subsets from normal tissue through dysplasia to cancer, accompanied by the upregulation of the CD47/SIRPα ‘don’t eat me signal’.ConclusionSpatial profiling revealed the molecular and immunological landscape of CRC tumourigenesis at early disease stage. We identified biomarkers with strong association with disease progression as well as targetable immune processes that are exploitable in a clinical setting.
Cardiopulmonary exercise testing excludes significant disease in patients recovering from COVID-19
Authors: Holdsworth D A , Barker-Davies R M , Chamley R R , O’Sullivan O , Ladlow P , May S , Houston A D , Mulae J , Xie C , Cranley M , Sellon E , Naylor J , Halle M , Parati G , Davos C , Rider O J , Bennett A B , Nicol E D 
Published: November 2022

ObjectivePost-COVID-19 syndrome presents a health and economic challenge affecting ~10% of patients recovering from COVID-19. Accurate assessment of patients with post-COVID-19 syndrome is complicated by health anxiety and coincident symptomatic autonomic dysfunction. We sought to determine whether either symptoms or objective cardiopulmonary exercise testing could predict clinically significant findings.Methods113 consecutive military patients were assessed in a comprehensive clinical pathway. This included symptom reporting, history, examination, spirometry, echocardiography and cardiopulmonary exercise testing (CPET) in all, with chest CT, dual-energy CT pulmonary angiography and cardiac MRI where indicated. Symptoms, CPET findings and presence/absence of significant pathology were reviewed. Data were analysed to identify diagnostic strategies that may be used to exclude significant disease.Results7/113 (6%) patients had clinically significant disease adjudicated by cardiothoracic multidisciplinary team (MDT). These patients had reduced fitness (V̇O226.7 (±5.1) vs 34.6 (±7.0) mL/kg/min; p=0.002) and functional capacity (peak power 200 (±36) vs 247 (±55) W; p=0.026) compared with those without significant disease. Simple CPET criteria (oxygen uptake (V̇O2) >100% predicted and minute ventilation (VE)/carbon dioxide elimination (V̇CO2) slope <30.0 or VE/V̇CO2slope <35.0 in isolation) excluded significant disease with sensitivity and specificity of 86% and 83%, respectively (area under the receiver operating characteristic curve (AUC) 0.89). The addition of capillary blood gases to estimate alveolar–arterial gradient improved diagnostic performance to 100% sensitivity and 78% specificity (AUC 0.92). Symptoms and spirometry did not discriminate significant disease.ConclusionsIn a population recovering from SARS-CoV-2, there is reassuringly little organ pathology. CPET and functional capacity testing, but not reported symptoms, permit the exclusion of clinically significant disease.