bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of Ultrasonography for Diagnosis of Salivary Gland Sialolithiasis: A Meta‐Analysis
Authors: Kim Do Hyun , Kang Jun Myung , Kim Sung Won , Kim So‐Hyun , Jung Jae Hoon , Hwang Se Hwan 
Published: January 2022

ObjectivesWe hypothesized that ultrasonography for salivary gland stone detection would have a diagnostic accuracy similar to that confirmed by sialendoscopy, sialography, or surgery. Therefore, we evaluated the diagnostic characteristics of ultrasonography in terms of submandibular and parotid stone detection compared to confirmatory methods.MethodsWe searched PubMed, Embase, the Web of Science, SCOPUS, and the Cochrane database to October 31, 2021. The risk of bias was evaluated using the QADAS‐2 tool.ResultsTen studies involving 1393 patients were included in the analysis. The diagnostic odds ratio of ultrasonography was 162.6013 (95% confidence interval [CI] [53.9883; 489.7208] and I2 value 81.0%). The area under the summary receiver operating characteristic curve was 0.963. The sensitivity, specificity, negative predictive value, and positive predictive value were 0.8992 (95% CI [0.8534; 0.9318]; I2 = 79.9%), 0.9664 (95% CI [0.9290; 0.9844], I2 = 65.6%), 0.8076 (95% CI [0.7256; 0.8694]; I2 = 80.4%), and 0.9853 (95% CI [0.9629; 0.9943]; I2 = 77.4%), respectively. However, high‐level among‐study heterogeneity (I2 ≥ 50%) was evident, attributable to the inclusion of different glands. On subgroup analysis, significant differences in the negative predictive values (parotid gland only [0.9392], submandibular gland only [0.6718], and parotid and submandibular glands [0.8105]) were apparent. We found no significant among‐study difference in the sensitivity, specificity, positive predictive value, or diagnostic odds ratio (P > .05).ConclusionUltrasonography usefully detects submandibular and parotid gland stones. Ultrasonography of the parotid gland was associated with the highest diagnostic accuracy, but further clinical studies are needed.Level of EvidenceNA Laryngoscope, 132:1785–1791, 2022
Nature‐based solutions in soil restoration for improving agricultural productivity
Authors: Mrunalini Kancheti , Behera Biswaranjan , Jayaraman Somasundaram , Abhilash Purushothaman Chirakkuzhyil , Dubey Pradeep Kumar , Swamy Gutta Narayana , Prasad Jasti Venkata Naga Satya , Rao Kondru Venkateswara , Krishnan Pandian , Pratibha Gudapaty , Srinivasa Rao Cherukumalli 
Published: January 2022

AbstractSoil is a living and dynamic body, which is prone to degradation under conventional agricultural practices. Healthy soil is one of the most important pillars of sustainability as it delivers several ecosystem services along with its control on microbial activity, nutrient recycling, and decomposition. Nature‐based solutions can play an important role in restoring soil quality for enhanced agricultural productivity and sustainability. This article discusses various nature‐based options available for improving soil quality. Indigenous practices such as sheep penning, tank silt application, green manuring, and refuse from croplands and households have the potential to restore and maintain soil fertility. Biofertilizers can add nutrients (N fixers), fixe up to 300 kg N ha through biological nitrogen fixation (BNF) and facilitate (nutrient solubilizer and mobilizers) nutrient availability in the soil. Biochar, a commonly used product, can increase soil moisture availability by 8%–10% and aids in mitigating climate change through C‐sequestration. Biochar may have a climate change mitigation potential of 1.8 Pg CO2‐C equivalent per year. When added to the soil, it not only acts as a nutrient source; but also acts as a soil amendment. Biogas slurry, the effluent from biogas reactors, contains various nutrient elements that can enrich soil fertility. The holistic approach in a farming system, through integration of different enterprises, reduces dependence on off‐farm resources. Soil management through nature‐based options will maintain crop productivity and sustainability in the long run without any adverse effects on the environment.
Dissimulate or disseminate? A survey on the fate of negative results
Authors: Herbet Marie‐Emilia , Leonard Jérémie , Santangelo Maria Grazia , Albaret Lucie 
Published: January 2022

AbstractA 34‐question survey was sent to researchers in chemistry, physics, engineering and environmental sciences, with the aim of identifying their relationship with unsuccessful research results as well as the obstacles to and incentives for their dissemination. Most of the 310 participants were affiliated with French research and teaching institutions. Conducted within the framework of the Datacc project (datacc.org) on research and data management, supported by Lyon and Grenoble Alpes University Libraries, our study fills the gap in literature on the disciplines concerned with reporting negative results in scholarly research. It shows that 81% of the researchers surveyed have already produced relevant negative results and 75% say they are willing to publish this type of data. However, only 12.5% of respondents have had the opportunity to do so in a scientific journal. This gaping contrast between intention and practice raises questions about the barriers and potential solutions.
Ultrafast MHz‐Rate Burst‐Mode Pump–Probe Laser for the FLASH FEL Facility Based on Nonlinear Compression of ps‐Level Pulses from an Yb‐Amplifier Chain
Authors: Seidel Marcus , Pressacco Federico , Akcaalan Oender , Binhammer Thomas , Darvill John , Ekanayake Nagitha , Frede Maik , Grosse‐Wortmann Uwe , Heber Michael , Heyl Christoph M. , Kutnyakhov Dmytro , Li Chen , Mohr Christian , Müller Jost , Puncken Oliver , Redlin Harald , Schirmel Nora , Schulz Sebastian , Swiderski Angad , Tavakol Hamed , Tünnermann Henrik , Vidoli Caterina , Wenthaus Lukas , Wind Nils , Winkelmann Lutz , Manschwetus Bastian , Hartl Ingmar 
Published: January 2022

AbstractThe Free‐Electron Laser (FEL) FLASH offers the worldwide still unique capability to study ultrafast processes with high‐flux, high‐repetition rate extreme ultraviolet, and soft X‐ray pulses. The vast majority of experiments at FLASH are of pump–probe type. Many of them rely on optical ultrafast lasers. Here, a novel FEL facility laser is reported which combines high average power output from Yb:YAG amplifiers with spectral broadening in a Herriott‐type multipass cell and subsequent pulse compression to sub‐100‐fs durations. Compared to other facility lasers employing optical parametric amplification, the new system comes with significantly improved noise figures, compactness, simplicity, and power efficiency. Like FLASH, the optical laser operates with 10‐Hz burst repetition rate. The bursts consist of 800‐μs long trains of up to 800 ultrashort pulses being synchronized to the FEL with femtosecond precision. In the experimental chamber, pulses with up to 50‐μJ energy, 60‐fs full‐width half‐maximum duration and 1‐MHz rate at 1.03‐μm wavelength are available and can be adjusted by computer‐control. Moreover, nonlinear polarization rotation is implemented to improve laser pulse contrast. First cross‐correlation measurements with the FEL at the plane‐grating monochromator photon beamline are demonstrated, exhibiting the suitability of the laser for user experiments at FLASH.
Shining light on multi‐drug resistant Candida auris: Ultraviolet‐C disinfection, wavelength sensitivity, and prevention of biofilm formation of an emerging yeast pathogen
Authors: Mariita Richard M. , Davis James H. , Lottridge Michelle M. , Randive Rajul V. 
Published: January 2022

AbstractCandida auris is an emerging fungal superbug of worldwide interest. It is associated with high mortality rates and exhibits increased resistance to antifungals. Ultraviolet subtype C (UVC) light can be used to disinfect surfaces to mitigate its spread. The objectives of this study were (1) To investigate UVC disinfection performances and wavelength sensitivity of C. auris. (2) To evaluate the UVC dose required for the prevention of biofilm formation on stainless‐steel, plastic (polystyrene), and poly‐cotton fabric surfaces. C. auris was grown following standard procedures. The study utilized six different UVC LED arrays with wavelengths between 252 and 280 nm. Arrays were set at similar intensities, to obtain doses of 5–40 mJ cm−2 and similar irradiation time. Disinfection performance for each array was determined using log reduction value (LRV) and percentage reduction by comparing the controls against the irradiated treatments. Evaluation of the ability of 267 nm UVC LEDs to prevent C. auris biofilm formation was investigated using stainless‐steel, plastic coupons, and poly‐cotton fabric. Peak sensitivity to UVC disinfection was between 267 and 270 nm. With 20 mJ cm−2, the study obtained ≥LRV3. On stainless‐steel coupons, 30 mJ cm−2 was sufficient to prevent biofilm formation, while on plastic, this required 10 mJ cm−2. A dose of 60 mJ cm−2 reduced biofilms on poly‐cotton fabric significantly (R2 = 0.9750, p = 0.0002). The study may allow for the design and implementation of disinfection systems.
Adipofascial anterolateral thigh free flap in hypopharyngeal and oropharyngeal reconstruction
Authors: Xu Feng , Deng Di , Li Baofei , Li Linke , Liu Jifeng , Li Bo , Liu Jun , Chen Fei 
Published: January 2022

AbstractBackgroundThe anterolateral thigh (ALT) flap is a popular choice for head and neck reconstruction surgery, but its ungainly thickness makes it of limited value in some intracavitary reconstructions. The ALT adipofascial flap is an improved flap without skin or muscle. Here, we seek to further illustrate the ALT adipofascial flap as an alternate method of hypopharyngeal and oropharyngeal reconstruction in head and neck.MethodsA retrospective review of 9 patients (7 men, 2 women) ranging from 28 to 67 years (mean age, 53.1 years) who underwent reconstruction with the ALT adipofascial flap after hypopharyngeal carcinoma (4 patients) or oropharyngeal carcinoma (5 patients) resections from August 2018 to December 2019 was performed. Surgical outcomes and functional resoration were assessed.ResultsThe size of the flaps ranged from 6 × 4 cm2 to 6 × 12 cm2. The average flap thickness was 0.14 cm (range, 0.1–0.2 cm) and the average pedicle length was 9.8 cm (range, 7–12 cm). The postoperative course was uneventful in eight patients. Reconstruction was successful in all cases during 7–23 months of follow‐up (mean time, 14.3 months). All patients resumed oral feeding for 2–8 weeks (mean time, 4.9 weeks) and the tracheal cannula was successfully removed 0.5–4 months postsurgery (mean time, 2.4 months).ConclusionThe ALT adipofascial flap is a viable choice for hypopharyngeal and oropharyngeal reconstructions and is thinner than the ALT flap. It could be harvested as a single‐pedicled double‐island flap for complex defect reconstruction.
Exploiting the Kronecker product structure of φ−functions in exponential integrators
Authors: Muñoz‐Matute Judit , Pardo David , Calo Victor M. 
Published: January 2022

AbstractExponential time integrators are well‐established discretization methods for time semilinear systems of ordinary differential equations. These methods use functions, which are matrix functions related to the exponential. This work introduces an algorithm to speed up the computation of the function action over vectors for two‐dimensional (2D) matrices expressed as a Kronecker sum. For that, we present an auxiliary exponential‐related matrix function that we express using Kronecker products of one‐dimensional matrices. We exploit state‐of‐the‐art implementations of functions to compute this auxiliary function's action and then recover the original action by solving a Sylvester equation system. Our approach allows us to save memory and solve exponential integrators of 2D+time problems in a fraction of the time traditional methods need. We analyze the method's performance considering different linear operators and with the nonlinear 2D+time Allen–Cahn equation.
Proteomic profiling identifies novel diagnostic biomarkers and molecular subtypes for mucinous tubular and spindle cell carcinoma of the kidney
Authors: Xu Huiya , Li Wei , Zhu Chongmei , Cheng Na , Li Xiaoxia , Hao Fengyun , Zhu Junfeng , Huang Liyun , Wang Ran , Wang Liantang , Luo Zhenhua , Wang Fen 
Published: January 2022

AbstractMucinous tubular and spindle cell carcinoma (MTSCC) is a relatively rare renal epithelial neoplasm resembling type 1 papillary renal cell carcinoma (PRCC) morphologically and immunohistochemically. The accurate diagnosis of MTSCC remains a challenge. Here, by using proteomic profiling, we characterized MTSCC and PRCC to identify diagnostic biomarkers. We found that the MTSCC tumor proteome was significantly enriched in B‐cell‐mediated immunity when compared with the proteome of adjacent normal tissues of MTSCC or tumors of PRCC. Importantly, we identified MZB1, VCAN, and SOSTDC1 as diagnostic biomarkers to distinguish MTSCC from the solid variant of type 1 PRCC, with an AUC of 0.985 when combined. MZB1 was inversely correlated with tumor clinical stage and may play an anti‐tumor role by activating the complement system. Finally, unsupervised clustering revealed two molecular subtypes of MTSCC, displaying different morphology, expression signatures of oxidative phosphorylation, and aggravation. In summary, our analyses identified a three‐protein diagnostic panel and molecular subtypes for MTSCC. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Plasma treatment application to improve interfacial adhesion in polypropylene‐flax fabric composite laminates
Authors: Leone Giulia , D'Angelo Gennaro Antonio , Russo Pietro , Ferraro Pietro , Pagliarulo Vito 
Published: January 2022

AbstractRecently, due to environmental and sustainability issues, the scientific community has been attracted to renewable natural resources, even for the development of materials intended for structural applications. This work deals with the pre‐treatment of a flax fiber fabric by exploring the effects of the exposure time to nitrogen plasma on the ultimate performance of polypropylene matrix composite laminates potentially usable for the realization of internal parts in the naval sector. Flax fabrics were treated with three different exposure times (5, 10, and 15 min) with the aim to improve the adhesion between the hydrophilic fibers and the hydrophobic matrix. At first, transverse and longitudinal wicking tests were carried out on the treated fabrics in order to evaluate the improvement of the absorption constants after the formation of reactive groups on their surface. The results collected so far in terms of fabric water uptake, tensile, and flexural properties as well as morphological aspects (SEM analysis) and damage evolution (ESPI technique), have indicated that the optimal pre‐treatment time of the reinforcing fabrics is equal to 15 min. Compared to the laminate with untreated fabrics, the specimen with flax fibers treated for 15 min displays higher tensile properties with an increase of 6.8% and 22.31% in ultimate strength and modulus, respectively. More in general, the achievements of this research might be useful to extend the current range of applications of flax fibers even in industrial fields still dominated by conventional fibers.
Musculoskeletal physiotherapy in physical sequelae of SARS‐CoV‐2 infection: A case report
Authors: Santos Sarita , Flores Juan A. 
Published: January 2022

AbstractBackgroundPatients infected with severe acute respiratory syndrome‐CoV‐2 can present physical complications that can make the return to their daily physical activities difficult. Despite the positive results in different pathologies through musculoskeletal physiotherapy, there are few reports in post‐COVID‐19 patients. This case describes an intervention based on musculoskeletal physiotherapy in a post‐COVID‐19 adult woman with physical sequelae.MethodsAs part of an initial evaluation in a woman with physical sequelaes post‐COVID‐19, it was decided to conduct a musculoskeletal physiotherapy over a course of 5 weeks distributed in 15 visits. To evaluate her progress the joint ranges were evaluated according to the American Academy of Orthopedic Surgeons (AAOS), the Numerical pain scale was used, the muscle strength evaluated according to the Daniel Scale, and finally the Unipodal Station Test used.ResultsMusculoskeletal physiotherapy improved the patient's physical symptoms. The patient's pain was reduced from a value of 10 to 3; the strength of the musculature increased from a value of 2 to 4; initial joint ranges were expanded from 67% to 100% in various body segments. Finally, the woman managed to stay up to 8 s in the monopodal position.DiscussionUsing musculoskeletal physical therapy and measuring progress through quantitative measurements at each visit, a post‐COVID‐19 woman was able to resume her daily physical activities. This therapy is a valuable tool to recover the musculoskeletal system that proves to be an important advance in the recovery of the quality of life in patients with musculoskeletal sequelae from COVID‐19.
Effect of myofascial release, stretching, and strengthening on upper torso posture, spinal curvatures, range of motion, strength, shoulder pain and disability, and quality of life in breast cancer survivors
Authors: Rao Mounica Srinivas , Pattanshetty Renu B. 
Published: January 2022

AbstractBackground and PurposeBreast cancer survivors are known to develop upper torso pain and stiffness including shoulder elevation and ipsilateral inclination of the trunk within a short period of time as a result of cancer adjuvant therapies correlating with the type and side of surgery. Hence, the study.MethodsTwenty‐two breast cancer survivors at a tertiary care hospital, Belgaum, Karnataka, have participated in this pre‐post experimental study which included myofascial release (MFR), stretching, and strengthening for four sessions per week for 3 weeks that is, a total of 12 sessions. The participants were assessed at baseline and post‐intervention using photogrammetry for Posture and shoulder range of motion (ROM), flexicurve for spinal curvatures, digital inclinometer for cervical ROM, manual muscle testing and hand dynamometer for strength of the upper back, shoulder muscles and hand grip, Shoulder Pain and Disability Index (SPADI) for shoulder impairment and Functional Assessment of Cancer Therapy‐Breast (FACT‐B) for quality of life.ResultsThe outcomes were analyzed with a p‐value set at ≤0.05. The results of the study demonstrated a substantial improvement in the posture alignment (p = 0.001), shoulder and cervical ROM (p = 0.001), upper back and shoulder muscle and hand grip strength (p = 0.001), SPADI (p = 0.001), and FACT‐B (p = 0.001) values.DiscussionThe upper torso malalignment and muscular imbalance is seen in patients who has undergone surgeries involving the chest wall and early physiotherapy intervention can benefit the patients overall physical performance and quality of life. Hence, MFR, stretching and strengthening has shown to be beneficial in improving upper torso malalignment in breast cancer survivors.Implications of Physiotherapy PracticeThe suggested techniques can be applied at a larger scale which can involve patients with head and neck cancer since the areas of intervention are identical.CTRI (Clinical Trial Registry‐ India) Registration No.: CTRI/2021/01/030453.
Streamlining physiologically‐based pharmacokinetic model design for intravenous delivery of nanoparticle drugs
Authors: Le Anh‐Dung , Wearing Helen J. , Li Dingsheng 
Published: January 2022

AbstractPhysiologically‐based pharmacokinetic (PBPK) modeling for nanoparticles elucidates the nanoparticle drug’s disposition in the body and serves a vital role in drug development and clinical studies. This paper offers a systematic and tutorial‐like approach to developing a model structure and writing distribution ordinary differential equations based on asking binary questions involving the physicochemical nature of the drug in question. Further, by synthesizing existing knowledge, we summarize pertinent aspects in PBPK modeling and create a guide for building model structure and distribution equations, optimizing nanoparticle and non‐nanoparticle specific parameters, and performing sensitivity analysis and model validation. The purpose of this paper is to facilitate a streamlined model development process for students and practitioners in the field.
Consumption of sesame seeds and sesame products has favorable effects on blood glucose levels but not on insulin resistance: A systematic review and meta‐analysis of controlled clinical trials
Authors: Sohouli Mohammad Hassan , Haghshenas Niloufar , Hernández‐Ruiz Ángela , Shidfar Farzad 
Published: January 2022

AbstractSesame, with an oily seed containing oil, lignans, and proteins, is a popular plant that has demonstrated health benefits such as antioxidative, antiobesity, and antiinflammatory effects. In this systematic review and meta‐analysis, we aimed to summarize the effect of sesame seeds and their consumption compared to a control group on blood glucose and insulin resistance in human adults. PubMed/MEDLINE, SCOPUS, Web of Science, Google Scholar, and EMBASE were searched to identify eligible controlled clinical trials up to February 2021. Finally, eight clinical trials were included in this study. Sesame products used in these trials were sesame oil, sesamin, and tahini, and the duration of the intervention varied from 45 days to 9 weeks. Our results showed the significant positive effects of sesame and its products on fasting blood glucose FBG (weighted mean difference, WMD: −21.31 mg/dl, 95% CI: −41.23, −1.39,p = .036) and HbA1c (WMD: −0.75, 95% CI: −1.16, −0.34,p < .001) levels but results about fasting serum insulin (WMD: 5.51 μU/ml, 95% CI: −2.31, 13.33,p = .167) and HOMA‐IR (WMD: −0.07, 95% CI: −0.33, 0.20,p = .617) were not meaningful. Sesame may be considered a beneficial agent for human glucose metabolism and can be a part of glucose‐lowering diets.
Robust active disturbance rejection control for systems with internal uncertainties: Multirotor UAV application
Authors: Chebbi Jawhar , Briere Yves 
Published: January 2022

AbstractActive Disturbance Rejection Control (ADRC) has recently stood out as a viable alternative to the proportional–integral–derivative controllers. An interesting field of application of this approach is the control of multirotor unmanned aerial vehicles (UAVs) which are inevitably subject to various force and torque disturbances. What makes ADRC attractive is the enhanced trajectory tracking and disturbance rejection capabilities that it allows while requiring minimal knowledge about the system. Although in theory, large uncertainties on the few required system parameters do not affect the stability of the ADRC's closed‐loop, they cause performance deterioration and can lead to dangerous oscillations that result in instability in practice. In this study, we design a robust ADRC for multirotor UAVs that allows maintaining the performance despite large parameter variations, without changing the initial control gains tuning. Simulation and experimental results support the theoretical findings.