bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Material of Carbonaceous Compressions from the ∼1.5 Ga Singhora Group, Chhattisgarh Supergroup, India, and their Interpretation as Benthic Algae
Authors: Singh Veeru Kant , Sharma Mukund 
Published: July 2022

The origin, antiquity, and affinity of benthic seaweeds (multicellular algae) in the geological past are shrouded in mystery due to their preservation bias. In this study, we present a new material of well-preserved carbonaceous compression fossils in shale horizons of the Mesoproterozoic (ca. ∼1,500–1,300 Ma) Singhora Group of the Chhattisgarh Supergroup. Eleven distinct taxa, including one new taxon,Palaeoscytosiphon shuklaii, n. gen. et. sp., and one new species,Jiuqunaoella sergeevii, n. sp., are established. Four unidentified morphologies are also reported. Morphologically, the carbonaceous fossils are fan-shaped, palmate, elongated, leaf-like algal thalli with/without holdfast at the base, isolated or dichotomously branched long filaments, along with multicellular reproductive structures. The results of laser Raman spectroscopy and energy dispersive X-ray spectroscopy (EDX) are also presented in support of their biogenicity. Collectively, the preservation mode of the Singhora carbonaceous fossils suggests multicellular algal affinity and adds to a Burgess Shale-type (BST) taphonomic window in the Pre-Ediacaran biosphere.
Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma
Authors: Yin Xiang-Qian , Yin Xue-Hui , Yu Ya-Qin , Xu Lang , Zhang Mao 
Published: July 2022

The RTK/RAS pathway is an oncogenic signaling pathway for which many targeted drugs have been developed; however, survival remains poor. A combination of targeted therapy and immunotherapy has emerged as an option for improving cancer treatment responses. In this study, on the basis of the expression, survival, single nucleotide variation (SNV), copy number variation (CNV), and methylation data of lung adenocarcinoma (LUAD) from The Cancer Genome Atlas database, we comprehensively analyzed the genomic changes in the RTK/RAS pathway and their associations with tumor-infiltrating lymphocytes (TIL) and prognosis in LUAD to provide the genomics landscape of RTK/RAS with TIL and prognosis. We found that two rarely mutated genes, mitogen-activated protein kinase kinase 1 and insulin-like growth factor 1 receptor, were significantly associated with the worse survival of patients with LUAD. Patients with LUAD and co-mutation of KRAS proto-oncogene (KRAS) and neurofibromin 1 genes had worse survival, and the underlying mechanism could be insufficient for protein synthesis and intracellular signal deactivation. Methylation of the Rac family small GTPase 1 (RAC1) was associated with better survival. The SNVs of the top mutated genes, including epidermal growth factor receptor (12.7%), neurotrophic receptor tyrosine kinase 3 (7.8%), erb-b2 receptor tyrosine kinase 4 (8.5%), and KRAS (29.6%), were associated with T cell exhaustion in LUAD. To construct nomograms, we further screened the genes whose genomic changes were closely associated with survival and immune infiltration. The nomograms performed well in predicting disease-specific survival (DSS) with a concordance index of 0.7 (0.589, 0.811) and overall survival with a concordance index of 0.689 (0.603, 0.775) in test set; they also showed good correspondence between actual and ideal nomogram predictions. Tumor stage, RAC1 methylation, and type 1 regulatory T cells greatly contributed to DSS and OS nomograms. In summary, we provided a comprehensive genomic profile of the RTK/RAS pathway in LUAD and its association with immune cell infiltration and prognosis of LUAD. This profile would serve as a basis for developing better therapeutic strategies, improving patient prognosis, and understanding the mechanisms of immune disturbance from the perspective of oncogenic pathways of LUAD.
Adhoc Setup of an Online Mental Health Self-Help Program During the COVID-19 Pandemic: Description of the Development and Implementation Processes and Analysis of Its Users’ and Usage Profiles
Authors: Galffy Matyas , Bichler Carina , Mohr Thomas , Egeter Jonas , Neu Leonie , Oberhammer Maria , Högl Birgit , Deisenhammer Eberhard A. , Sperner-Unterweger Barbara , Hüfner Katharina 
Published: July 2022

BackgroundThe COVID-19 pandemic hit Austria in March 2020. This led to a considerable reduction in outpatient psychiatric therapies. People with mental disorders as well as with newly emerging mental health issues found themselves with very limited treatment options. Within only a few days our hospital set up an online mental health self-help program which went online in its first version on the first day of the lockdown in Austria. The process of this development and implementation process alongside with the user’s and usage data for the program are presented here.MethodsA small core team initiated the development of the program on a low-budget basis and using mostly freely available digital resources. The program had to be free of costs for its users and easy to navigate. Each self-help module contains a text description of the topic, a self-rating questionnaire and several psychoeducational 2–5 min videos. These videos explain, e.g., interactions of mental stress and the immune system or the vicious circle of anxiety. Additional videos provide easy to learn techniques like breathing and relaxation exercises.ResultsWe illustrate the implementation of this program following the replicating effective program (REP) model. We provide a detailed description of the implementation process starting from a simple website to a smartphone-based application with registered user area and instantaneous reporting of self-rating questionnaire results to users. The described process could be used as a model for the setup of similar programs in a very short time. As an indicator of acceptance, we report 46,100 unique video views and 3,937 completed questionnaires in the first year of use. The most accessed videos were those on anxiety, relaxation and resilience. Analysis of the sociodemographic user data indicate that they were mostly young (&lt; 45 years; 59.7%), females (77.5%) and previously mentally healthy individuals (74.5%). An example of the collected psychometric questionnaire data over time is given.ConclusionWe show that it is possible to set up an online mental health self-help programad hocand without extensive prior planning, which enabled us to dynamically respond to a new situation. We are now planning on keeping the program active for a longer period of time to supplement and expand traditional treatment settings also outside the COVID-19 pandemic.
Prognostic model of immune-related genes for patients with hepatocellular carcinoma
Authors: Cai Qun , Duan Jinnan , Ding Liang 
Published: July 2022

BackgroundImmune-related genes (IRGs) are closely connected to the occurrence and development of tumors. Their influence on the prognosis of patients with HCC, however, remains unclear.MethodsFrom the TCGA database, we integrated 365 liver cancer tissues and 50 normal tissues to identify differential immune genes related to prognosis. Multivariate COX analysis was used to establish a new prognostic index on account of IRGs, whereby risk score = (Expression level of HSPA4*0.022) + (Expression level of PSMD14*0.042) + (Expression level of RBP2*0.019) + (Expression level of MAPT*0.197) + (Expression level of TRAF3*0.146) + (Expression level of NDRG1*(0.006) + (Expression level of NRAS*0.027) + (Expression level of IL17D*0.075).ResultsThe risk score was clearly correlated with an unfavorable survival rate and with clinical characteristics. By integrating the immune-related risk score model with clinical features, a nomogram was constructed to predict the survival rate of HCC patients (1-, 3- and 5-year AUC of 0.721, 0.747 and 0.781, respectively).ConclusionWe have established a valuable prognostic risk score for HCC patients that may be a better predictor of survival than the present method. With the risk score's strong predictive value for immune cells and functions, it may provide clinical guidance for the diagnosis and prognosis of different immunophenotypes, and provide multiple therapeutic targets for the treatment of HCC patients based on subtype-specific immune molecules.
Propuesta de modernización del sistema de control de temperatura de la Máquina Flejadora de la Empresa Mixta Compacto caribe S.A de Santiago de Cuba
Authors: Canjimbi Ngombe L. C. , Giralt Sánchez A. , Garbey Torres M. , Andrial Mora Y. 
Published: July 2022

El presente trabajo tiene como objetivo modernizar el sistema de control de temperatura de la Máquina Flejadora de la Empresa Mixta Compacto Caribe S.A de Santiago de Cuba. Esta propuesta es elaborada mediante un control lógico programable, se establece el control de temperatura ON/OFF con un rango de 270ºc a 300ºc. Se realizó la programación del PLC utilizando el software SoMachin Basic. Se explican los sistemas de control, la instrumentación, y un sistema de supervisión del proceso soportado sobre el Software SoMachine, Vijeo Designer.

Palabras claves— Flejadora, PLC.,
Diseño de un sistema de control automático para la alimentación de caña del tándem en el central “Argeo Martínez”
Authors: Bazan de los Santos M. , Giralt Sánchez A. , Garbey Torres M. , AndrialMora Y. 
Published: July 2022

En ésta investigación se proyecta un sistema de control automático, que garantiza el flujo constante de caña al primer molino del tándem en el Central Argeo Martínez de la provincia de Guantánamo en Cuba; de forma que se garantiza la eficiencia de extracción de jugos durante el proceso de molienda. Para esto fue necesario caracterizar los sistemas de alimentación de caña, así como el análisis de la situación actual del proceso en dicho central. Se presenta además, la arquitectura del sistema de control propuesto, la selección de la estrategia de control, así como el modelado y cálculo de la potencia de los motores que demandada el proceso. Se caracterizaron los diferentes instrumentos que se usan en el proceso. Se describió el PLC de la marca Mitsubishi de la serie FX3U -32M.

Palabras claves— Regulador de frecuencia, micro-controladores PSoC, centrales hidroeléctricas.
IDENTIFIKASI PROFIL FITOKIMIA DAUN TORBANGUN (Coleus amboinicus) UNTUK MENINGKATKAN PRODUKSI ASI
Authors: Yulinda Dwi , Rahmawati Sholihah Nur 
Published: July 2022

Coleus amboinicus merupakan tumbuhan yang memiliki metabolit sekunder yaitu saponin, alkaloid, flavonoid, polifenol dan minyak atsiri. Senyawa yang sangat berpengaruh terhadap peningkatan produksi ASI termasuk dalam polifenol. Beberapa bentuk pemanfaatan daun torbangun banyak digunakan untuk meningkatkan produksi ASI dalam bentuk tablet dan teh. Perlunya inovasi baru untuk lebih meningkatkan daya konsumsi adalah dengan membuat simplisia daun torbangun dalam bentuk effervescent. Perlu dilakukan penelitian untuk mengetahui kandungan metabolit sekunder daun torbangun. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder daun torbangun melalui uji fitokimia. Penelitian eksperimental dengan metode kualitatif untuk mengetahui kandungan fitokimia pada daun torbangun dilakukan di laboratorium farmasi. Dimulai dengan ekstraksi dan dilanjutkan dengan pengujian. Identifikasi profil fitokimia dapat dilihat dari perubahan warna dan karakteristik ekstraksi daun torbangun dengan menambahkan beberapa bahan kimia yang berfungsi untuk mengikat fitokimia. Karakteristik organoleptic bentuk serbuk kering, warna hijau kehitaman, bau langu, rasa pahit. Fitokimia yg teridentifikasi antara lain alkaloid, flavonoid, saponin, terpenoid dan steroid, serta tannin. Hasil pengembangan KLT akan dideteksi di bawah sinar tampak, UV 254, dan UV 366 untuk melihat pola kandungan senyawanya.
Coleus amboinicus is a plant that has secondary metabolites, namely saponins, alkaloids, flavonoids, polyphenols and essential oils. Compounds that are very influential on increasing breast milk production include polyphenols. Several forms of utilization of torbangun leaves are widely used to increase breast milk production in the form of tablets and tea. The need for new innovations to further increase consumption power is to make torbangun leaf simplicia in the form of effervescent. Research needs to be done to determine the content of secondary metabolites of torbangun leaves. This study aims to determine the content of secondary metabolites of torbangun leaves through phytochemical tests. Experimental research using qualitative methods to determine the phytochemical content of torbangun leaves was carried out in a pharmaceutical laboratory. Starting with extraction and continued with testing. Identification of the phytochemical profile can be seen from the color changes and the extraction characteristics of torbangun leaves by adding several chemicals that function to bind phytochemicals. Organoleptic characteristics of dry powder form, blackish green color, unpleasant odor, bitter taste. The identified phytochemicals include alkaloids, flavonoids, saponins, terpenoids and steroids, and tannins. The results of the TLC development will be detected under visible light, UV 254, and UV 366 to see the pattern of the compound content.
MEDIA BUKU SAKU (PAMIL) UPAYA PENCEGAHAN ANEMIA KEHAMILAN TERHADAP TINGKAT PENGETAHUAN IBU
Authors: Rohmatika Dheny , Prastyoningsih Aris , Nurlaly Ari Febru , Hapsari Erlyn , Widyastutik Desy , Wijayanti Wijayanti 
Published: July 2022

Kehamilan sangat rentan mengalami terjadinya anemia defisiensi besi, penyebab anemia defisiensi besi pada kehamilan yaitu hemodilusi shingga pengenceran darah, pertambahan darah tidak sebanding pertambahan plasma, kurangnya zat besi dalam makanan, kebutuhan zat besi meningkat dan gangguan pencernaan, absorbs, perdarahan post partum. Salah satu penyebab Angka kematian Ibu secara tidak langsung. Tujuan penelitian Efektifitas Media Buku Saku Upaya Pencegahan Anemia Terhadap pengetahuan ibu hamil. Penelitian ini merupakan penelitian kuantitatif dengan desain penelitian eksperimen dengan rancangan pre experimental designs, teknik pengambilan sampel adalah total sampling. Sampel dalam penelitian ini sebanyak 30 responden. Hasil penelitian berdasarkan analisis menggunakan uji wilcoxon test dapat disimpulkan terdapat pengaruh tingkat pengetahuan kelompok perlakukan sebelum dan setelah perlakuan (p-Value 0,000). Sehingga dapat disimpulkan terdapat pengaruh Media Buku Saku Upaya Pencegahan Anemia terhadap tingkat pengetahuan ibu hamil.

Pregnancy is very susceptible to iron deficiency anemia, the cause of iron deficiency anemia in pregnancy is hemodilution so that blood thins, blood increase is not proportional to plasma increase, lack of iron in food, increased iron needs and digestive disorders, absorption, post partum bleeding. One of the causes of maternal mortality is indirectly. The purpose of this research is the effectiveness of the Pocket Book Media on Anemia Prevention Efforts on the knowledge of pregnant women. This research is a quantitative research with experimental research design with pre experimental designs, the sampling technique is total sampling. The sample in this study were 30 respondents. The results of the study based on the analysis using the Wilcoxon test, it can be concluded that there is an influence on the level of knowledge of the treatment group before and after treatment (p-Value 0.000). So it can be concluded that there is an effect of Pocket Book Media on Anemia Prevention Efforts on the level of knowledge of pregnant women.
PERBANDINGAN DAYA HAMBAT VARIASI EKSTRAK ETANOL BIJI PEPAYA(Carica papaya L.) TERHADAP PERTUMBUHAN Escherichia coli ESBL
Authors: Stephen Dewangga Vector , Prian Nirwana Ardy , Destivani Virliana Widjayanti Laurencia 
Published: July 2022

Latar belakang: Extended-Spectrum Beta Lactamase (ESBL) merupakan enzim yang diproduksi oleh bakteri gram negatif salah satunya adalah E coli. Dimana bakteri jenis ini mampu menghasilkan enzim betalaktamase yang dapat melawan jenis antibiotik beta laktam. Prevalensi terjadinya infeksi oleh bakteri penghasil ESBL sebesar 50,60%. Tujuan: penemuan bahan alami yang dapat menjadi alternatif baru untuk mengatasi masalah infeksi Escherichia coli ESBL. Metode: Penelitian ini menggunakan jenis penelitian analitik eksperimental dengan melakukan uji aktivitas antibakteri untuk mengetahui adanya perbandingan daya hambat ekstrak etanol 70% dan etanol 96% biji pepaya (Carica papaya L) terhadap pertumbuhan Escherichia coli ESBL. Penelitian ini menggunakan sampel biji Carica papaya L yang diambil pada buah pepaya matang, segar dan kemudian dikeringkan. Biji Carica papaya L diekstraksi menggunakan cara perkolasi dengan pelarut etanol 70% dan etanol 96% yang kemudian dibuat dalam konsentrasi 100.000 ppm, 200.000 ppm, 300.000 ppm, 400.000 ppm, dan 500.000 ppm. Aktivitas antibakteri menggunakan metode difusi cakram dengan media MHA. Hasil: Pada penelitian ini didapatkan hasil dengan uji Kruskal Walis dengan nilai sig sebesar <0,001 dan dapat disimpulkan bahwa terdapat perbedaan yang bermakna pada daya hambat ekstrak etanol 70% dan etanol 96% biji pepaya (Carica papaya L) terhadap pertumbuhan Escherichia coli ESBL
Background: Extended-Spectrum Beta Lactamase (ESBL) is an enzyme produced by Gram-negative bacteria, one of which is E coli. This kind of bacteria is able to produce beta-lactamase enzymes that can fight against beta-lactam antibiotics. The prevalence of infection by ESBL-producing bacteria is 50.60%. Objective: To discover a natural ingredient that can be a new alternative to overcome the Escherichia coli ESBL infection. Method: This study was an experimental analytical research that tested antibacterial activity to determine the comparison of inhibition of ethanol 70% extract and ethanol 96% extract of papaya seeds (Carica papaya L) on the growth of Escherichia coli ESBL. This study used samples of Carica papaya L seeds taken from ripe and fresh papaya, that was then dried. Carica papaya L seeds were extracted using percolation method with ethanol 70% and ethanol 96% solvent which were then made in concentrations of 100,000 ppm, 200,000 ppm, 300,000 ppm, 400,000 ppm, and 500,000 ppm. Antibacterial activity used disc diffusion method with MHA media. Results: The result of this study showed that sig value of Kruskal Walis test was <0.001. Thus, it can be concluded that there is a significant difference in the inhibition of ethanol 70% extract and ethanol 96% extract of papaya seeds (Carica papaya L) on the growth of Escherichia coli ESBL.
PENGARUH ART DRAWING THERAPY TERHADAP TINGKAT KECEMASAN PADA IBU HAMIL PRE EKLAMSI
Authors: Murharyati Atiek , Kartikasari Meilinda , Mardiyah Siti , Mar’atus Sholihah Maula , Rima Agustin Wahyu , Ernawati E 
Published: July 2022

Pre eklamsi adalah hipertensi yang terjadi pada ibu hamil dalam usia kehamilan ≥20 minggu atau sesudah persalinan yang ditandani dengan meningkatnya tekanan darah ≥140/90 MmHg, proteinurin positif dan edema. Ibu hamil dengan pre eklamsi memiliki kerentanan fisik dan psikologis lebih tinggi dibanding ibu dengan kehamilan normal karena memiliki resiko kegagalan dalam kehamilan dan persalinan yang lebih besar sehingga dapat mengakibatkan kecemasan. Kecemasan dapat diturunkan dengan art drawing therapy, art drawing therapy merupakan kegiatan yang menggunakan alat gambar dan warna sebagai media dengan tujuan agar dapat mengekspresikan emosinya. Penelitian ini menggunakan desain penelitian quasi experiment dengan pendekatan pre and post test without control group design. Populasi dalam penelitian ini adalah ibu hamil pre eklamsi yang berada di kecamatan Jati, pengambilan sample menggunakan tekhnik total sampling. Jumlah sampel 31 responden. Instrument untuk mengukur kecemasan ibu hamil pre eklamsi adalah Hamilton Rating Scale (HARS). Art drawing therapy dilakukan sebanyak 3 sesi dan setiap sesi dilakukan sau kali pertemuan selama 60 menit. Analisa data menggunakan uji Wilcoxon hasil penelitian ini menunjukan ada pengaruh pemberian art drawing therapy terhadap tingkat kecemasan pada ibu hamil pre eklamsi dengan dengan nilai p<0,000 (p value < 0,05). Kesimpulan, terdapat pengaruh art drawing therapy terhadap tingkat kecemasan ibu hamil pre eklamsi.
Pre-eclampsia is hypertension that occurs in pregnant women at gestational age 20 weeks or after delivery which is characterized by increased blood pressure 140/90 MmHg, positive proteinuria and edema. Pregnant women with pre-eclampsia have higher physical and psychological vulnerabilities than mothers with normal pregnancies because they have a greater risk of failure in pregnancy and childbirth so that it can cause anxiety. Anxiety can be reduced by art drawing therapy, art drawing therapy is an activity that uses drawing and color tools as a medium in order to express emotions. This study uses a quasi-experimental research design with a pre and post test approach without a control group design. The population in this study were pre-eclampsia pregnant women who were in Jati sub-district, the sample was taken using a total sampling technique. The number of samples is 31 respondents. The instrument to measure the anxiety of pre-eclampsia pregnant women is the Hamilton Rating Scale (HARS). Art drawing therapy was carried out in 3 sessions and each session was held once for 60 minutes. Analysis of the data using the Wilcoxon test. The results of this study showed that there was an effect of giving art drawing therapy on the level of anxiety in pre-eclampsia pregnant women with a p value < 0.000 (p value < 0.05). In conclusion, there is an effect of art drawing therapy on the anxiety level of pre-eclampsia pregnant women
Cambios de forma y tamaño en el cráneo humano: el efecto de las transiciones dietarias
Authors: Paschetta Carolina , González-José Rolando 
Published: July 2022

Evaluamos diferentes subregiones del cráneo para detectar si los cambios en la consistencia de los alimentos producen un efecto en la variación de tamaño y forma. Se analizaron tres transiciones económicas poblacionales y tres poblaciones no transicionales. Se digitalizaron noventa coordenadas de landmarks en 3D en una muestra de 459 cráneos y se analizaron mediante morfometría geométrica. Adicionalmente se estimo la fuerza de mordida para cada grupo. Nuestros resultados indican diferencias de tamaño entre las transiciones y las regiones craneales. Los cambios de forma se concentran en la inserción de los músculos temporal y masetero, que muestran un alargamiento anteroposterior en los grupos de dieta dura en relación con los grupos de dieta blanda. Otros cambios importantes ocurren en el arco cigomático, que es más ancho en los grupos de dieta dura. La fuerza de mordida en general es mayor en los grupos que representan las dietas más duras.