bluuebunny/crossref_metadata_2025_split huggingface dataset:
Look Into My Onco-forest - Review of Plant Natural Products with
Anticancer Activity
Authors: Michalak Izabela , Püsküllüoğlu Mirosława 
Published: March 2022

Abstract:
Cancer is a multistage process that numerous modalities including systemic treatment can treat. About half of the molecules that have been approved in the last few decades count for plant derivatives. This review presents the application of tree/shrub-derived biologically active compounds as anticancer agents. Different parts of trees/shrubs - wood, bark, branches, roots, leaves, needles, fruits, flowers, etc. - contain a wide variety of primary and secondary metabolites that demonstrate anticancer properties. Special attention was paid to phenolics (phenolic acids and polyphenols, including flavonoids and non-flavonoids (tannins, lignans, stilbenes)), essential oils, and their main constituents such as terpenes/terpenoids, phytosterols, alkaloids, and many others. The anticancer properties of these compounds are mainly attributed to their strong antioxidant prop-erties. In vitro experiments on various cancer cell lines revealed a cytotoxic effect of tree-derived extracts. Mechanisms of anticancer action of the extracts are also listed. Examples of drugs that successfully underwent clinical trials with well-established positions in the guidelines created by oncological societies are provided. The review also focuses on directions for the future in the devel-opment of anticancer agents derived from trees/shrubs. Applying biologically active compounds de-rived from trees and shrubs as anticancer agents continuously seems promising in treating systemic cancer.
Computational Modeling on Binding Interactions of Cyclodextrin s with the Human Multidrug Resistance P-glycoprotein Toward Efficient Drug-delivery System Applications
Authors: González-Durruthy Michael , Concu Riccardo , Dias Soeiro Cordeiro Maria Natália , Osmari Vendrame Laura F. , Ortiz Martins Mirkos , Zanella Ivana , Ruso Juan Manuel 
Published: March 2022

Background:Herein, molecular docking approaches and DFT ab initio simulations were combined for the first time, to study the key interactions of cyclodextrins (CDs: α-CD, β-CD, and γ-CD) family with potential pharmacological relevance and the multidrug resistance P-gp protein toward efficient drug-delivery applications. The treatment of neurological disorders and cancer therapy where the multiple drug-resistance phenomenon mediated by the P-gp protein constitutes the fundamental cause of unsuccessful therapies.Objective:To understand more about the CD docking mechanism and the P-gp.Methods:In order to achieve the main goal, the computational docking process was used. The observed docking-mechanism of the CDs on the P-gp was fundamentally based on hybrid backbone/side-chain hydrophobic interactions,and also hybrid electrostatic/side-chain interactions of the CD-ligands' OH-motifs with acceptor and donor characteristics, which might theoretically cause local perturbations in the TMD/P-gp inter-residues network, influencing ligand extrusion through the blood-brain barrier. P-gp residues were conformationally favored. Despite the structural differences, all the cyclodextrins exhibit very close Gibbs free binding energy values (or affinity) by the P-gp binding site (transmembrane domains - TMDs).Results:The obtained theoretical docking-mechanism of the CDs on the P-gp was fundamentally based on hybrid backbone/side-chain hydrophobic interactions, and also hybrid electrostatic/side-chain interactions of the OH-motifs of the CD-ligands with acceptor and donor properties which theoretically could induce allosteric local-perturbations in the TMDs-inter-residues network of P-gp modulating to the CD-ligand extrusion from the blood-brain-barrier (or cancer cells).Conclusion:Finally, these theoretical results open new horizons for evaluating new nanotherapeutic drugs with potential pharmacological relevance for efficient drug-delivery applications and precision nanomedicine.
Supported Ionic Liquids and their Applications in Organic Transformations
Authors: Singh Pradeep Pratap , Ambika  
Published: March 2022

Abstract:Ionic liquids are one of the greener solvents which have emerged as a replacement for toxic and harmful volatile organic solvents. In the past decade, the concept of supported ionic liquids (SILs) has attracted the attention of the scientific community due to their unique chemical and phys-ical properties. SILs can be synthesized by coating a thin layer of IL film onto/into the surface of solid support. They can be classified as supported IL phase catalyst, solid catalyst with IL and sup-ported IL catalysis. SILs demonstrated the combined properties of both heterogeneous and homoge-neous catalysts. These ILs offer several advantages such as enhanced stability, reusability, recovera-bility, easy product isolation, absence of IL leaching, as compared to conventional solvents. In this review, various aspects of SILs, classification, method of preparation and their applications in var-ious organic transformations such as cross-coupling reactions, oxidation, reduction, synthesis of dif-ferent heterocyclic compounds, biocatalytic reactions etc., have been discussed.
A Molecular Insight into Pyrazole Congeners as Antimicrobial, Anticancer,
and Antimalarial Agents
Authors: Karati Dipanjan , Mahadik Kakasaheb Ramoo , Trivedi Piyush , Kumar Dileep 
Published: March 2022

Background:
Pyrazole is a bioactive heterocyclic congener with numerous biological and
pharmacological functionalities. Due to their multiple prospective applications, developing innovative
and novel pyrazoles and analogs, revealing revolutionary methods for synthesizing this nucleus,
investigating diverse potencies of that heterocycle, and exploring possible pyrazole applications are
becoming increasingly relevant.

Objectives:
Pyrazole scaffolds have been proven successful as antimicrobial, anticancer, and antimalarial
therapeutics against multiple targets like DNA gyrase, topoisomerase IV, Hsp90, and several
kinase enzymes. For this variability in the biotic zone, their moiety has gained the attention of many
scientists interested in researching chemical and pharmacological profiles.

Results:
The review covers pyrazole scaffolds with a variety of biological functions and attempts to
connect the structure-activity relationship. Multiple pyrazole analogs have been produced as lead
compounds, and their activities have been evaluated.

Conclusion:
The combination of pyrazole with other pharmacophores in a molecule might lead to
novel potent therapeutic medicines, which could aid in the development of potent lead compounds.
A Review of Bayesian Networks Applications for Electrical Systems
Authors: Hamza Zerrouki 
Published: March 2022

Abstract:
The development in the field of electrical energy has been growing increasingly due to
the need for this energy in daily life. The reliability and safety of electrical power systems and
equipment represent complex problems that are difficult to solve by conventional methods such as
Fuzzy Logic and Artificial Neural Networks. Bayesian network is recently used to overcome some
limitations in conventional methods. This paper represents a bibliographic review about the use of
Bayesian networks in the field of electric systems. This paper seeks to answer the following questions:
(i) What are the areas of interest? (ii) What are the most active countries in this field?? (iii)
Who are the most participating authors in this field? (iv) which year witnessed the largest number of
publications? (v) What is the most widespread field related to this research? (vi) What is the most
used system in terms of application? This field witnesses a slight increase in the number of publications
in the last two decades (1999–2021), with a note of a sharp increase in publishing in the last
two years. It is observed that reliability assessment and fault diagnosis are the most common fields.
Furthermore, it is found that China and USA are the active countries in this field. Electric Power and
Energy Systems Journal and IEEE Transactions on Power Systems Journal are the lead source documents,
and most of the documents used electric power systems as an application. This paper will
help researchers to know the versability features of BN and to identify the gaps in the use of BN in
electric domains.
Trajectories of Uremic Symptom Severity and Kidney Function in Patients with Chronic Kidney Disease
Authors: Wulczyn Kendra E. , Zhao Sophia H. , Rhee Eugene P. , Kalim Sahir , Shafi Tariq 
Published: March 2022

Background and objectives
Uremic symptoms, including fatigue, anorexia, pruritus, nausea, paresthesia, and pain, are attributed to the accumulation of organic waste products normally cleared by the kidneys, but whether kidney function is the primary driver of changes in symptom severity over time is not known. The goal of our study was to evaluate the association between eGFR and uremic symptom severity score in patients with CKD.

Design, setting, participants, and measurements
We identified 3685 participants with CKD not on dialysis in the prospective, observational Chronic Renal Insufficiency Cohort (CRIC) Study with baseline assessment of eGFR and uremic symptom severity. Symptoms were assessed by separate questions on the Kidney Disease Quality of Life-36 instrument (zero- to 100-point scale). The longitudinal association between eGFR and uremic symptom severity score was examined with multivariable adjusted linear mixed-effects models with random intercepts and random slopes.

Results
The mean±SD eGFR at baseline was 44±15 ml/min per 1.73 m2, and participants had a median of six (interquartile range 3–11) simultaneous assessments of eGFR and uremic symptoms over the duration of follow-up. The most prevalent symptoms at baseline were pain (57%), fatigue (52%), paresthesia (45%), and pruritus (42%). In adjusted models, a decrease in eGFR of 5 ml/min per 1.73 m2 was associated with a worsening of the symptom severity score by two points or less for each uremic symptom (P<0.01; zero- to 100-point scale). The association between eGFR and uremic symptom severity score was nonlinear. When starting from a lower initial eGFR, a 5 ml/min per 1.73 m2 decrease in eGFR was associated with a greater magnitude of uremic symptom worsening.

Conclusions
The prevalence of uremic symptoms in CKD is high, with significant variability in patient symptom change over time. Declines in eGFR were associated with worsening of uremic symptom severity, but the magnitude of these changes is small and of uncertain clinical significance.
Gestión y medición del capital intelectual (activos intangibles) en las organizaciones
Authors: Aduna Lira Enrique 
Published: March 2022

El presente estudio se centra en la comprensión y medición del capital intelectual (CI), término que es alusivo a los activos intangibles en el campo de la gestión de las organizaciones. Involucra la descomposición de sus diferentes dimensiones que la integran, como son el capital humano, el capital estructural y el capital relacional. El tema se desarrolla con un abordaje de análisis cualitativo, basado en investigación documental de diversas fuentes consultadas, identificando las dimensiones, componentes y variables específicas que deben de ser contempladas en el contenido de un modelo de medición del CI (intangibles).
Los resultados que arroja este trabajo no solo son la comprensión de todo un marco teórico de referencia sobre el tema en cuestión y sus mecanismos de medición, que justifican la importancia y contribución que tienen esta clase de bienes intangibles en los impactos concretos que se pueden lograr, sino también se proponen en los resultados del estudio una serie de modelos o conceptualizaciones nuevas para la gestión y desarrollo del CI en las organizaciones. Estas propuestas buscan ser una aportación a la aplicación práctica del tema, pero que con sus respectivos alcances, como se mencionan en las conclusiones del trabajo, pueden llegar a convertirse en una aplicación automatizada (software) que facilite su medición cotidiana.
Notas codicológicas sobre algunos testimonios de las Siete Partidas
Authors: Fradejas Rueda José Manuel 
Published: March 2022

El deber básico de todo investigador que aborde la edición de un texto con transmisión manuscrita, e incluso impresa, es el examen directo de todos los testimonios. Alberto Blecua indicaba, también, que “son sumamente importantes las descripciones (…) antiguas de manuscritos” (1983, p. 38). El trabajo de campo realizado en las bibliotecas y archivos que conservan algún testimonio de las Siete Partidas y el análisis de muchas de las viejas descripciones nos han mostrado que se han de tomar con cierta prevención debido a la poca atención que se le ha prestado tanto al soporte material como al contenido de esos testimonios. Producto de la revisión y análisis directo de los originales son las tres notas codicólogicas siguientes. En la primera, se establece que una copia manuscrita conservada en el Archivo Histórico de la Nobleza (Toledo) está basada en un ejemplar de la edición incunable de Díaz Montalvo (1491). En la segunda se demuestra que la tabla inicial del ms. VITR/4/6 de la BNE no está desplazada y que se reubicó en ese lugar cuando se creó el volumen definitivo a lo largo de la segunda mitad del siglo xv. En el tercero se demuestra que el ms. 8721 de la BNE contiene una copia completa, pero mutilada de la Séptima Partida.
La princesa Kristina de Noruega en la novela histórica postmoderna: proyecciones ficcionales e interpretaciones actuales de la cultura alfonsí
Authors: Albert Mechthild 
Published: March 2022

El presente artículo analiza el reciente boom de novelas históricas dedicadas a la princesa Kristina de Noruega (1234–1262), esposa del infante Felipe de Castilla, que contribuyen a construir la época de Alfonso X como lugar de la memoria desde una perspectiva actual, enfocando, entre otros, la condición femenina, la convivencia intercultural y la idea de Europa. Asimismo, varios recursos metaficcionales sirven a poner de relieve la relación entre ficta y facta.
The impact of urban expansion in Beijing and Metropolitan Area urban heat Island from 1999 to 2019
Authors: Yang Jinpei , Alahmadi Khaled Mohammad , Shirowzhan Sara 
Published: March 2022

Abstract
This article is a quantitative study of the urban expansion of Beijing in the past two decades and its impact on the city’s heat island effect. The overall idea of this paper is a ‘basic fact description to phenomenon and law reveal-basic cause analysis-mechanism analysis-model simulation’. In this paper, the effects of urbanisation on warming in Beijing are deduced by nonlinear fitting method. Based on Google Earth Engine remote sensing image data within Beijing Inner Sixth Ring Road and using ArcGIS to retrieve Beijing’s surface temperature, the heat island effect intensity index is calculated. This paper quantitatively analyses the temporal and spatial distribution characteristics and development trends of Beijing’s urban heat island effect, combined with land use cover change (LUCC), Land Surface Temperature (LST), Normalised difference Vegetation Index (NDVI), Normalised difference Building Index (NDBI), which can explore the impact of surface vegetation distribution and building density on the urban heat island effect.
Arabidopsis thaliana for Spaceflight Applications–Preparing Dormant Biology for Passive Stowage and On-Orbit Activation
Authors: Sng Natasha J. , Callaham Jordan , Ferl Robert J. , Paul Anna-Lisa 
Published: March 2022

Abstract
Biological experiments on-orbit that demonstrate the effects of gravity on plants require precise control of the initiation of plant development. Preserving seed dormancy is critical to experiments that endeavor to study the effects of the orbital environment, independent of contributions from either a normal gravity, or launch. However, spaceflight experiments are often tightly constrained with respect to the configuration of the biology and associated hardware, and it is rarely possible to launch dry seeds separated from their growth substrate. Described here are techniques established to maintain viable seeds that can remain dormant for up to a month at room temperature, and hydrated on the surface of solid, Phytagel growth medium. The configuration can also accommodate a brief (less than one minute) exposure to light during the quiescent period for quick inspection for any breaks in dormancy, and for contamination. The data presented outline the preparation of sealed, Phytagel media plates of dormant Arabidopsis thaliana seed that can be activated in situ when unwrapped and installed within a lighted growth habitat. These protocols were developed primarily for spaceflight scenarios where seeded plates must be prepared ahead of time and kept at ambient temperatures. However, these protocols can be adapted for any field application where it is desirable to transport dormant, seeded plates to a remote location where it would not be possible to prepare sterile culture plates.
Sumberdaya Arkeologi Menuju Industri Pariwisata di Maluku: Masalah, Peluang, Tantangan dan Solusinya
Authors: Handoko Wuri 
Published: March 2022

Wilayah Maluku memiliki konstribusi besar sebagai daerah yang banyak menyimpan sumberdaya warisan budaya (cultural heritage). Namun sejak terpecah menjadi dua provinsi, masing-masing mengejar PAD, yang kemudian terkesan menelantarkan potensi sumber daya budaya tersebut. Besarnya potensi sumberdaya budaya dan arkeologi itu sesungguhnya dapat dikembangkan menjadi obyek industry pariwisata. Namun hal ini perlu dilakukan melalui perencanaan yang matang yang diawali dengan menjaring aspirasi dari bawah (bottom up). Hal ini untuk memperoleh dukungan kolektif public, sebagai salah satu syarat agar industri pariwisata dapat berkembang. Bagaimanapun masyarakat sangat berhak, mengingat sumberdaya arkeologi justru banyak dijumpai diwilayah pemukiman masyarakat setempat. Namun demikian untuk mengembangkan sebuah industry wisata, perlu dilakukan melalui berbagai upaya skala prioritas mengingat Maluku masih dalam proses pemulihan sosial.
Kerajaan Sahulau: Melacak Fragmen Sejarah Yang Hilang, Potret Sejarah, Tutur dan Arkeologi
Authors: Sudarmika G.M. , Handoko Wuri 
Published: March 2022

One of countryside in middle Regency Maluku region, trusted by Moluccassociety as a empire secondhand in old world. That countryside is so called of Countryside Sahulau. In a few history note and say society, mentioning this empire represent big empire founded by somebody coming from so called Buton of La Ode Muna. This Figure is myth as a miraculous but his body is not perfect, his body human being like snake. History note mention this empire fall to pieces in the year 1858 when a period of/to Dutch occupying. But regional previously this represent a empire region of a period of Islam and Colonial. If previously assumed this empire have annihilate and nothing; there is no existence marking and also considered to be a missing history, hence archaeology mean to try to attend something that have disappeared the. Pursuant to archaeology data, there are some indication that Sahulau is true aim to secondhand a empire of a period of/to Colonial and Islam. Some foreign ceramic evidence, walk stick Sahulau supported by area sites, environmental condition and the social face of society culture which look cultural growth of old world life which still hold out. Small tread of archaeology though still very the and need continuation data minim, but can early making way to tread empire Sahulau history therewith [his/its] cultural dynamic.
Rare case of migration and perforation of the urinary bladder by ventriculoperitoneal shunt catheter with intravesical knotted formation: A case report and literature review
Authors: Guimarães Amanda Silva , Vaz Júnior Mário , Martins Samuel Paiva , Fagundes-Pereyra Walter J. 
Published: March 2022

Background:The most commonly used technique in the management of hydrocephalus is a neurosurgical procedure, known as ventriculoperitoneal shunt (VPS). Several complications of the distal end of a VPS catheter have been described in the literature, although migration and erosive bladder perforation of this shunt are extremely uncommon.Case Description:We relate a rare pediatric case of a 4-year-old boy, with long-term dysuria, intermittent incontinence, and chronic abdominal pain developed during a myelomeningocele postoperative period, without other symptoms. A bladder fistula with the distal end of the VPS inside the bladder was observed while performing an ultrasound to investigate the urinary tract. Two months before the current surgical approach, the patient, with hydrocephalus and alterations compatible with Chiari malformation, was treated with VPS and subsequently subjected to the third ventriculostomy. The child was unsuccessfully treated with an infraumbilical laparotomy, with section and careful traction of the catheter. A vesicostomy was then performed and the catheter was observed to form an intravesical knot.Conclusion:The intravesical knot formation is extremely rare and its mechanism of formation is still not well understood. Patients with VPS need adequate medical follow-up to identify possible complications of the shunt.
Development and Pre-Clinical Evaluation of Polyherbal Hand Wash
Authors: Prakash Gnana 
Published: March 2022

Hand-washing is significant in agriculture, housekeeping, and in addition vital in houses and daycare plans. The artificial handwash formulations an effort antiquated entice formulate a polyherbal hand wash victimization extract of Sida cardifolia, Azadirachta indica, aloe vera gel, and lemon juice. The pH of hand wash was ranging from 6.36 to 6.88. The handwash formulations were ranges from 56 cp to 62 cp. The formulation planned out along with lemon juice displayed the best antimicrobial utilization than the formulation while not lemon juice. The stableness reports no change in pH & Viscosity referred to in the formulations. The effects of the present work support the internalization as well as utilization of herbs in the formulation to help give better results.
EFFECT OF FREE VALENCE ON THE ELECTRON DENSITY DISTRIBUTION IN A BENZENE RING
Authors: Чернова Елена Михайловна , Русакова Наталья Петровна , Мирошниченко Евгений Александрович , Орлов Юрий Димитриевич 
Published: March 2022

Методом DFT B3LYP 6-311++G(3df,3pd) найдено распределение электронной плотности бензола и фенил-радикала. В рамках квантовой теории атомов в молекуле (QTAIM) проведено исследование влияния свободной валентности на структуру бензольного кольца.
The electron density of benzene and phenyl-radical were found by DFT B3LYP 6-311++G(3df,3pd) method. Within the framework of the quantum theory of atoms in a molecule (QTAIM), the effect of free valence on the structure of a benzene ring has been studied.