bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percepciones sobre el uso de bases de datos en investigación formativa en odontología
Authors: Bernal Cepeda Lilia Jadith , Tobar Sánchez Jesús Armando , Misas Avella Margarita María 
Published: January 2022

Actualmente existen varias estrategias para consultar información en la red en tiempo real sobre infinidad de temas, tanto asuntos de la cotidianidad de las personas como de campos del saber que son de interés para la comunidad académica. Las bases de datos se constituyen como herramientas eficientes para la trasmisión de información y su acceso, en general, resulta sencillo y rápido; sin embargo, en ocasiones estudiantes y docentes no las emplean con la frecuencia que se desearía, fenómeno del que se desconocen en gran medida las causas. El objetivo del presente trabajo fue indagar las percepciones de docentes y estudiantes de una Facultad de Odontología en Bogotá, en cuanto al uso de las bases de datos en investigación formativa, empleando la técnica de Clasificación Múltiple de Ítems –CMI-. Se pudo identificar que para la mayoría de los participantes se hace necesario implementar estrategias pedagógicas que promuevan el uso de estas; adicionalmente los participantes reconocen la importancia de los diferentes actores en el proceso enseñanza-aprendizaje y de la inclusión de las bases de datos en las diferentes actividades académicas e investigativas.
Beyond inclusion: practical lessons on striving for gender and disability transformational changes in WASH systems in Cambodia and Timor-Leste
Authors: Huggett Chelsea , Da Costa Cruz Livia , Goff Fraser , Pheng Pharozin , Ton Doeurn 
Published: January 2022

Abstract
Women and girls, and people with disabilities are often excluded from governance systems and decision-making on water, sanitation and hygiene (WASH) at all levels – from household to the national level. This paper analyses inclusion and empowerment outcomes for these two groups in three WASH system-strengthening programmes in Cambodia and Timor-Leste. The analysis used WaterAid's ‘Equality and Inclusion Framework’ to assess the quality of inclusion and empowerment outcomes at different levels of WASH systems. The review found that household gender equality changes in Timor-Leste were empowering because they shifted women's and men's roles, relationships and attitudes. It found that women's leadership and disability-inclusive approaches in Cambodia achieved inclusive outcomes because they enhanced women's critical consciousness and increased WASH leaders' awareness of the importance of disability inclusion. There was evidence of either individual/self-empowerment changes or changes to the enabling environment; however, no intervention achieved a comprehensive combination of both. The authors conclude that both individual and environmental outcomes contribute to empowerment outcomes in WASH systems at different levels that can shift gender norms, redistribute power and benefit women and people with disabilities. These findings will enable WASH practitioners to better understand empowerment outcomes and how to integrate them with system-strengthening approaches.
Community engagement in water, sanitation and hygiene in sub-Saharan Africa: does it WASH?
Authors: Tsekleves Emmanuel , Fonseca Braga Mariana , Abonge Christiana , Santana Marli , Pickup Roger , Yongabi Anchang Kenneth , de Pippo Tommaso , Semple Kirk , Roy Manoj 
Published: January 2022

Abstract
This transdisciplinary literature review paper aims at addressing the literature lacuna in community engagement and water, sanitation and hygiene (WASH) in sub-Saharan countries. By responding to a set of identified WASH-related questions to community engagement, it explores through different disciplinary lenses the challenges and opportunities in this significant area that impacts human health. This transdisciplinary review brought together the disciplines of water engineering, environmental microbiology, public health and infectious disease, design research, women and gender studies, and developmental studies. It examined over 430 papers with 29 papers included in the final review. The main findings suggest integrating women into leadership roles in community water management and water and sanitation programmes can lead to more sustainability and can make water projects more effective. Second, cultural preferences should be a key factor when planning and implementing WASH technologies and interventions. Third, for community engagement to be effective, it should be done with intentionality and over a longer period; and employ existing culturally embedded leadership structures, such as schoolteachers, religious leaders and train change agents.
Prioritization of maintenance work in wastewater networks using decision support methods
Authors: Mezhoud Cherifa , Berreksi Ali , Bedjou Abdelhamid , Bosseler Bert 
Published: January 2022

Abstract
Sanitation networks are extremely important infrastructures because of their function and capital-intensive nature. Indeed, network knowledge is essential for a reliable prioritization of maintenance work. In this context, this research work is interested in the evaluation and the prioritization of the defects of an Urban Sanitation Network (USN), taking into account the criteria of the FMECA method (failure mode and effects and criticality analysis), namely the probability of defect occurrence (P), the defect's detectability (D) and the defect impact (I). The methodology adopted is based on the combination of three methods: the analytic hierarchy process (AHP) used to assign weights to FMECA criteria, the weighted product model (WPM) method to determine the defect impact and the technique for order of preference by similarity to ideal solution method (TOPSIS) to classify sanitation defects in descending order in order to prioritize maintenance interventions. A case study of a real sewerage project in the city of Bejaia (Algeria) essentially composed of eight non-visitable sections evaluated from television inspections was used to illustrate and validate the proposed model. The results show that the following defects: collapse, chemical attack, pipe surface degradation, and abrasion are considered as critical defects requiring immediate intervention due to their significant influence on the section performance rate, which is between 0%≤P&lt;50%, contrary to the other studied parameters which present a performance rate of P&gt;50%. These results prove that the combination of AHP–WPM–TOPSIS methods can be used to design an effective management and maintenance system.
Controles internos para o gerenciamento de riscos: percepção de auditores e gestores
Authors: Marques dos Santos Isadora , Queiroz Souza Valdevino Rosângela , Silva de Queiroz Rosilania , Martins de Oliveira Adriana , Jéssica Freitas de Oliveira Letícia , Gislainy Marques da Silva Meskla 
Published: January 2022

Objetivo: O presente artigo tem como objetivo analisar a percepção dos auditores e gestores em relação aos controles internos no gerenciamento de riscos nas empresas.
Metodologia: A pesquisa é descritiva e qualitativa. Foram realizados dois roteiros de entrevistas divididos em duas partes: a primeira contendo 05 perguntas fechadas sobre a caracterização dos profissionais e a segunda os questionamentos direcionados a área da pesquisa. O primeiro roteiro foi dirigido aos auditores independentes e conteve 08 questionamentos abertos. O segundo foi apontado para as gestoras e conteve 10 perguntas abertas, sendo 07 questões elaboradas com base no referencial teórico da pesquisa e as demais foram retiradas do estudo de Peleias et al. (2017). O tratamento dos dados ocorreu por meio de análise de conteúdo com utilização do software Atlas/TI.
Resultados: Mediante os achados da pesquisa as gestoras afirmam terem um controle interno que colabora com o gerenciamento de riscos, nesse sentido investem sempre em programas, pois afirmam que ajudam na prevenção de erros. Na ótica dos auditores independentes as organizações de Mossoró têm controle interno e programas que colaboram para o gerenciamento de riscos, no entanto, os funcionários não são habilitados para operacionalizar as ações nos sistemas. O que compromete o desempenho dos resultados. Diante das análises realizadas é possível compreender as diferentes concepções em relação ao controle interno das empresas.
Contribuições do Estudo: A contribuição da pesquisa no aspecto teórico é confrontar as diferentes percepções de auditores e gestores, quanto a utilização do controle interno no gerenciamento de riscos em uma realidade prática. No que se refere ao aspecto prático, o estudo tem o intuito de observar o que é visto pelos auditores e o que não é percebido dentro das organizações, nesse sentido a operacionalização do controle interno é avaliado como eficaz, mas em diferentes anglos que apresentam uma realidade especifica da cidade de Mossoró, assim a pesquisa mostra que é possível sanar problemas de execução do controle interno, proporcionando um melhor desempenho e eficácia do gerenciamento de riscos.
Socio environmental responsibility practices and organizational performance in public companies
Authors: Tres Naline , Porta Claudia Dalla , Mazzioni Sady , Magro Cristian Baú Dal , Domenico Daniela Di 
Published: January 2022

Purpose: Analyze the relationship between socio-environmental responsibility practices in the economic and financial performance of companies listed in [B3].
Methodology: Social and environmental information found in the annual sustainability reports published in accordance with the GRI 4 (Global Reporting Initiative) standard were used. For economic performance, the metrics EBITDA and ROA were considered, while for financial performance, market-to-book and Tobin's Q were used, collected on the Economática® platform. Binomial logistic regression was used to evaluate 220 observations corresponding to the period from 2014 to 2018.
Results: It was not possible to verify the relationship between the disclosure of socio-environmental practices on economic performance, measured by the companies' accounting result variables. However, it suggests that there is a negative influence of the disclosure of information on socio-environmental practices on the financial performance measured by market variables.
Study Contributions: Despite the demands made by the set of stakeholders on companies for the practice of socioenvironmental actions, the market does not favorably recognize the organizational effort. The results point to indications that investors may consider organizational investments in socioenvironmental practices as undesirable.
Tax aggressiveness in publicly traded companies operating in a regulated market
Authors: França Thaís Salvatori , Bezerra Francisco Antonio 
Published: January 2022

Purpose: The research aims to identify whether the regulated market through its agencies is a determining factor for a posture of less tax aggressiveness in companies.
Methodology: BTD (Book-Tax Differences), ETRc (Current Effective Tax Rate) and CashETR (Cash Effective Tax Rate) were the indicators used in this study to measure the level of tax aggressiveness. The sample corresponded to all companies that traded their shares in B3, from 2010 to 2018.
Results: The results of this study show that companies that operate in a regulated market are less tax aggressive than companies that operate in the free market. It was thus noted that market regulation acts as a factor that discourages the implementation of more aggressive tax strategies.
Contributions of the Study: The practical contribution of this study was to evaluate the sectorial regulation model in force in the country, from the perspective of tax benefits and the control of tax aggressiveness. This study brings from theoretical contribution the need for a more effective participation of taxpayers for a regulatory model more guided by the mutual contribution between public administration and companies. Still under the theoretical aspect, the work contributes to the evaluation of sectorial regulation as a mechanism to control tax avoidance and reduce tax aggressiveness, in addition to providing initial study material for future research on the behavior of the regulated market in the face of tax aggressiveness.
Gastroenteropancreatic Neuroendocrine Neoplasms (GEP NENs): The
Role of Checkpoint Inhibitors
Authors: Fazio Nicola , Arrivi Giulia 
Published: January 2022

Background:
The treatment options for GEP-NENs include various drugs and are based
on grading, morphology, and location of the primary.

Objective:
The aim of our work is to investigate the clinical impact of new immune checkpoint inhibitors
in order to define a new possible strategy of use within GEP-NENs.

Method:
A scientific literature search from 2015 to January 2020 was performed using PubMed
and Embase: reviews and prospective or retrospective studies with a minimum of twenty patients
were selected; conference proceedings were included.

Results:
Several studies have been conducted to assess the role of immune checkpoint inhibitors in
NENs, but nowadays, the current knowledge in this field is mainly based on phase I-II studies. Immunotherapy
showed limited antitumor activity, but a higher response rate was reported in poor-differentiated
neuroendocrine tumors. No specific biomarkers were identified for patient selection and
response assessment.

Conclusion:
Immunotherapy appears as a powerful possibility to help our patients, but nowadays,
we see many gaps in this field. We must balance therapeutic possibilities offered by precision oncology
with an understanding of the limitations of the application of testing and treatment in clinical
practice. Future efforts should focus on research of the best patients to a candidate for immunotherapy
in terms of disease characteristics and previous treatments and how to select them
with accurate biomarkers.
A Comprehensive Review on Therapeutic Potentials of Natural Cyclic
Peptides
Authors: Kumar Suresh , Saharan Renu , Khokra Sukhbir Lal , Singh Sunil , Tiwari Abhishek , Tiwari Varsha , Sahoo Biswa Mohan , Kumar Manish 
Published: January 2022

Abstract:
Cyclic peptides have emerged as a promising class of organic compounds that possess
polypeptide chains with a cyclic ring structure. There is a circular sequence of bonds in which
the ring structure is formed via linkage between one end of the peptide bond and the other end
with an amide bond or any other chemically stable bonds like ether, thioether, lactone, and disulfide.
Generally, the cyclic peptides are isolated from natural resources like invertebrate animals,
micro-organisms of marine habitats, and higher plants. These cyclic peptides possess unique
structures with diverse pharmacological activities. Nowadays, cyclic peptides possess superior
therapeutic value due to several reasons such as greater resistance to enzymatic degradation (in
vivo) and higher bio-availability. Some of these cyclic peptides are rich in leucine, proline, while
some have other amino acids as their major constituents. Numerous novel cyclic peptides isolated
from natural sources are successfully developed as bioactive products. Recently, cyclic peptides
derived from natural resources have attracted attention for exploring their numerous beneficial
effects. Moreover, it is reported that natural cyclic peptides exhibit various therapeutic activities
like an anthelmintic, ACE inhibitor, anti-tumor, microtubule inhibitor, anti-fungal, antimalarial,
and platelet aggregation inhibiting activity. In this review, various cyclic peptides are
reported with structures and biological activities that are isolated from various natural sources.
The natural cyclic peptides possess a wide spectrum of biological activities and can become a
drug of the future for replacing the existing drugs which develop resistance.
Nanoformulation of Glycyrrhizic Acid as a Potent Antiviral Agent
Against Covid-19
Authors: Ghosh Sayani , Patra Prasun 
Published: January 2022

Abstract:
In many previous studies, liquorice plant (Glycyrrhiza glabra) extracts have been found to
contain more than 300 natural compounds, most of which are triterpenoids and flavonoids, and show
promising results in clinical studies for treating many microbial and viral infections. Triterpenoids, like
glycyrrhizic acid, have shown anti-SARS-CoV activity in vitro. Experimentally, certain glycyrrhizic
acid derivatives have shown increased activity by many folds against SARS-associated viruses. These
compounds can potentially inhibit the replication cycle of SARS-associated viruses by interfering with
the viral gene expression or by inhibiting the spike protein expression, which in turn inhibits the adhesion
and entry of the virus. Although the therapeutic has shown great antiviral activity in vitro, but in
vivo, its efficiency deteriorates till it reaches the liver for metabolism. In the current review, we analyze
the unique replication strategy of SARS-CoV-2 and glycyrrhizic acid as a potential drug against
SARS-CoV-2. We also discuss possible nanoformulations of glycyrrhizic acid for efficient drug delivery
in humans and as a potent therapeutic strategy for COVID-19.
Effect of web-based she smart education models on adolescent girl’s knowledge, attitudes, and practice about obesity
Authors: Herliah A. , Baso Yusring Sanusi , Hidayanty Healthy , Syarif Syafruddin , Aminuddin Aminuddin , Bahar Burhanuddin 
Published: January 2022

Obesity is a disorder characterized by excessive accumulation of body fat. The nutritional impact is more than just disturbing the aesthetics of appearance. Obesity (overweight and overweight) is a new chronic disorder that soon becomes a global pandemic that is quite difficult to control. To improve the knowledge, attitudes, and Practice of Adolescent Girls about obesity. Use Pre-Experiment with one group pre-test and post-test design. Sampling technique using purposive sampling and obtained a total of 47 respondents. The research was conducted in the Senior High School of 12 Makassar in September-October 2021. Data analysis using the McNemar test. The results of statistics showed that there is an influence on the use of the web-based She Smart education model of the knowledge and attitudes of Adolescent Girls with a value of p-value=0.008 (p<0.05). And there was no influence on the use of the web-based She Smart education model on the Practice of Adolescent Girls with a p-value of 0.453 (p>0.05). There is an influence on providing obesity education before and after intervention through web-based obesity education media in improving knowledge and attitudes but does not affect the Practice of adolescent girls in overcoming the problem of obesity.
Development of a Supportive Parenting App to Improve Parent and Infant Outcomes in the Perinatal Period: Development Study
Authors: Shorey Shefaly , Tan Thiam Chye , Thilagamangai   , Mathews Jancy , Yu Chun Yan , Lim Siew Hoon , Shi Luming , Ng Esperanza Debby , Chan Yiong Huak , Law Evelyn , Chee Cornelia , Chong Yap Seng 
Published: January 2022

Background
The transition to parenthood can be challenging, and parents are vulnerable to psychological disorders during the perinatal period. This may have adverse long-term consequences on a child’s development. Given the rise in technology and parents’ preferences for mobile health apps, a supportive mobile health intervention is optimal. However, there is a lack of a theoretical framework and technology-based perinatal educational intervention for couples with healthy infants.

Objective
The aim of this study is to describe the Supportive Parenting App (SPA) development procedure and highlight the challenges and lessons learned.

Methods
The SPA development procedure was guided by the information systems research framework, which emphasizes a nonlinear, iterative, and user-centered process involving 3 research cycles—the relevance cycle, design cycle, and rigor cycle. Treatment fidelity was ensured, and team cohesiveness was maintained using strategies from the Tuckman model of team development.

Results
In the relevance cycle, end-user requirements were identified through focus groups and interviews. In the rigor cycle, the user engagement pyramid and well-established theories (social cognitive theory proposed by Bandura and attachment theory proposed by Bowlby) were used to inform and justify the features of the artifact. In the design cycle, the admin portal was developed using Microsoft Visual Studio 2017, whereas the SPA, which ran on both iOS and Android, was developed using hybrid development tools. The SPA featured knowledge-based content, informational videos and audio clips, a discussion forum, chat groups, and a frequently asked questions and expert advice section. The intervention underwent iterative testing by a small group of new parents and research team members. Qualitative feedback was obtained for further app enhancements before official implementation. Testing revealed user and technological issues, such as web browser and app incompatibility, a lack of notifications for both administrators and users, and limited search engine capability.

Conclusions
The information systems research framework documented the technical details of the SPA but did not take into consideration the interpersonal and real-life challenges. Ineffective communication between the health care research team and the app developers, limited resources, and the COVID-19 pandemic were the main challenges faced during content development. Quick adaptability, team cohesion, and hindsight budgeting are crucial for intervention development. Although the effectiveness of the SPA in improving parental and infant outcomes is currently unknown, this detailed intervention development study highlights the key aspects that need to be considered for future app development.
The Pattern of Referral of Sick Omani Pilgrims From the Omani Medical Mission During Hajj 2019
Authors: Almashaykhi Ahmed Obaid , M Nooh Randa , Almudarra Sami Said , ALMutari Abdulaziz Saad , ALBudayri Naif Saud , AlGhamdi Khalid Masoud , Aldarwish Ali 
Published: January 2022

Background
Annually, in the month of Dhul hijjah, over 2 million Muslims travel to Saudi Arabia to perform hajj. Hajj is the biggest mass gathering globally, which creates a substantial influence on hajjes’ health. The Omani medical mission is the official delegation from the Omani government to Saudi Arabia to serve the Omani hajjees regarding their health issues.

Objective
This study investigates the referral rate and pattern of diseases among hajjees referred by the Omani medical mission during Hajj 1440 H.

Methods
We conducted a cross-sectional study at the Omani Medical missions in Makkah, Madinah, Mina, and Arafat. Data was collected via a predesigned form. All Omani pilgrims presenting to the mission who were referred to local hospitals were included.

Results
The total number of cases was 5000, of which 106 (2.1%) were referred to local hospitals (21.2 per 1000 hajjees). The most common causes of referral were cardiovascular diseases (23.6%), followed by gastrointestinal disease (17.9%) and trauma (16.9%). Male patients comprised 60.1% of the sample. Their mean age was 47.3 (SD 11.27) years, with the highest referrals in the 51-60 years age group (30%). Over half (55.7%) had comorbidities. Patients’ mean time to reach the clinic was 8.87 (SD 6.41) minutes, with 65% arriving in 5 minutes or less. The mean time needed to reach the hospital by ambulance was 11.39 (SD 6.6) minutes, with 36% arriving within 5 minutes. Of the referrals, 42% were admitted into the hospital. Hospitalization was significantly higher among patients with chest pain (P<.006), diabetics (P<.001), and patients with heart disease (P=.01).

Conclusions
The most common causes for referral of hajjees from the Omani Medical Mission were cardiovascular diseases, gastrointestinal disease, and trauma. This information should assist the Omani government in planning their medical services in the hajj season in future years.