bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laboratory evaluation of the compatibility of Beauveria bassiana with the egg parasitoid Trichogramma dendrolimi (Hymenoptera: Trichogrammatidae) for joint application against the oriental fruit moth Grapholita molesta (Lepidoptera: Tortricidae)
Authors: Wu Yanan , Fang Haibo , Liu Xiaoxia , Michaud J.P. , Xu Haoyang , Zhao Zhihua , Zhang Songdou , Li Zhen 
Published: May 2022

AbstractBACKGROUNDThe entomopathogenic fungus Beauveria bassiana and the egg parasitoid Trichogramma dendrolimi can both contribute to biological control of the global fruit borer Grapholita molesta. To derive insights for optimizing their combined application in augmentation programs, we assayed fungal pathogenicity to both G. molesta (eggs, larvae and adults) and adult parasitoids, and assessed wasp acquisition and transmission of fungal spores following their emergence from B. bassiana‐treated host eggs.RESULTSConcentrations of 108 conidia mL−1 of B. bassiana and higher caused virtually complete mortality of G. molesta larvae, but less than 30% mortality of eggs, and female moths surviving treatments had reduced fecundity. More than 80% of adult T. dendrolimi survived B. bassiana treatments of 107 conidia mL−1, and more than 60% survived 109 conidia mL−1, with surviving females achieving reproductive success equivalent to controls. Parasitoid females preferred healthy eggs over B. bassiana‐infected ones in choice tests; wasps emerging from treated eggs carried about 104 conidia each and contributed an additional 11% host mortality in trials combining both agents.CONCLUSIONOur results indicate that combined applications of B. bassiana and T. dendrolimi can have complimentary impacts on G. molesta, the wasps compensating for low fungal pathogenicity to eggs and their progeny potentially aiding in subsequent disease transmission. Although foraging wasps tended to avoid infected eggs, negative interactions between the two agents might be further mitigated by timing B. bassiana applications from late instar larva to early moth stage, and T. dendrolimi releases several days later to coincide with peak oviposition periods. © 2022 Society of Chemical Industry.
Population pharmacokinetic/pharmacodynamic joint modeling of ixazomib efficacy and safety using data from the pivotal phase III TOURMALINE‐MM1 study in multiple myeloma patients
Authors: Srimani Jaydeep K. , Diderichsen Paul M. , Hanley Michael J. , Venkatakrishnan Karthik , Labotka Richard , Gupta Neeraj 
Published: May 2022

AbstractIxazomib is an oral proteasome inhibitor approved in combination with lenalidomide and dexamethasone for the treatment of relapsed/refractory multiple myeloma (MM). Approval in the United States, Europe, and additional countries was based on results from the phase III TOURMALINE‐MM1 (C16010) study. Here, joint population pharmacokinetic/pharmacodynamic time‐to‐event (TTE) and discrete time Markov models were developed to describe key safety (rash and diarrhea events, and platelet counts) and efficacy (myeloma protein [M‐protein] and progression‐free survival [PFS]) outcomes observed in TOURMALINE‐MM1. Models reliably described observed safety and efficacy results; prior immunomodulatory drug therapy and race were significant covariates for diarrhea and rash events, respectively, whereas M‐protein dynamics were sufficiently characterized using TTE models of relapse and dropout. Moreover, baseline M‐protein was identified as a significant covariate for observed PFS. The developed framework represents an integrated approach to describing safety and efficacy with MM therapy, enabling the simulation of prospective trials and potential alternate dosing regimens.
Reliability allocation method of comprehensive weight computer numerical control machine tool based on failure correlation and factor correlation
Authors: Gu Dongwei , Xu Zhen , Zhong Yuhong , Li Qihan , Long Zhe 
Published: May 2022

AbstractAccording to the shortage of independent hypothesis allocation models between influence factors and subsystems, a reliability allocation method considering influence factor correlation and subsystem failure correlation is proposed. The CNC (Computer Numerical Control) machine tool is taken as the research object. Using Copula function to analyze failure correlation analysis between subsystems, establish subsystem complete reliability model and integrated importance measure model under failure correlation. The four factors of influencing reliability allocation are subsystem complexity, integrated importance measure of subsystem based on failure correlation, failure frequency, and specific gravity ratio of failure downtime. The correlation analysis among the influencing factors was carried out by using gray correlation theory, and the subjective weight of the subsystem was determined. The IEW‐VIKOR (Information Entropy Weight‐Vlsekriterijumska Optimizacija I Kompromisno Resenje) method is used to determine the objective weights of subsystems. The comprehensive weight of the subsystem is also obtained through combinatorial empowerment. The reliability allocation of the CNC machine tool subsystem was carried out according to the failure correlation reliability model, and the results of failure independence and failure correlation hypothesis allocation were compared and analyzed. When the reliability index is the same, the reliability allocation method proposed in this paper can assign lower reliability to each subsystem, which is of great significance to improve the reliability of CNC machine tools and reduce the difficulty of reliability design
Model‐driven engineering of safety and security software systems: A systematic mapping study and future research directions
Authors: Mashkoor Atif , Egyed Alexander , Wille Robert , Stock Sebastian 
Published: May 2022

AbstractThis article presents a systematic mapping study on the model‐driven engineering of safety and security concerns in software systems. Combined modeling and development of both safety and security concerns is an emerging field of research as both concerns affect one another in unique ways. Our mapping study provides an overview of the current state of the art in this field. This study carefully selected 143 publications out of 27,259 relevant papers through a rigorous and systematic process. This study then proposes and answers questions such as frequently used methods and tools and development stages where these concerns are typically investigated in application domains. Additionally, we identify the community's preference for publication venues and trends. The discussion on obtained results also features the gained insights and future research directions.
Optical spectroscopy and imaging in surgical management of cancer patients
Authors: Wilson Brian C. , Eu Donovan 
Published: May 2022

AbstractSurgery is a pillar of cancer management, the general goal being complete removal of solid tumor tissue with minimal damage to normal tissue structure and function. Optical imaging and spectroscopy may contribute to this at several points in the procedural chain, including preoperative tumor localization and staging by biopsy, intra/perioperative identification and localization of tumor margins, detection of residual tumor tissue and tumor‐involved lymph nodes as well as critical normal tissue structures, and assessment of the viability of reconstructed tissues following tumor resection. The numerous optical modalities that can be implemented clinically are discussed, a few of which are already in clinical practice and many more are in clinical trials. These modalities utilize different light‐tissue interactions and technical approaches. The resulting biological information obtained, the current or potential clinical impact, limitations and potential future developments and roles are considered. This article is intended to inform the biophotonics community of the clinical needs and scientific/technical challenges and opportunities in photonics‐enabled surgical guidance and to guide potential surgical users on the potential advantages and limitations in this rapidly evolving landscape.
Total intravenous anaesthesia with alfaxalone in two grey seals (Halichoerus grypus) undergoing enucleation
Authors: Gómez Fernández Laura , Potter Joanna , Huuskonen Vilhelmiina 
Published: May 2022

AbstractTwo young grey seals, from a seal rescue organisation, were presented to the University College Dublin Veterinary Hospital for unilateral eye enucleation. After premedication (pethidine–midazolam–atropine combination given intramuscularly), induction was performed with alfaxalone, and anaesthesia was maintained with alfaxalone total intravenous anaesthesia. During recovery, one of the seals developed severe bradycardia, apnoea and cardiac arrest resulting in death. The other recovered uneventfully after a short period of respiratory distress. Both seals had a suspected infectious pneumonia based on preoperative thoracic radiographs. This case report details the anaesthetic protocols used, the challenges presented to the anaesthetist by this species, and suggests that some complications could be potentially mitigated by more judicious use of anticholinergic agents.
Military History: An Introduction
Authors: Poulsen Niels Bo 
Published: May 2022

AbstractThis chapter offers an introduction to military history. It outlines the relation between history in general and the subdiscipline of military history. Traditionally military history has been “war-centric” and during the late nineteenth and early twentieth century a significant split occurred between military professionals who studied the past in order to find military lessons and establish principles of war and civilian academics who increasingly came to see military history as methodologically primitive and war-glorifying. Contemporary military history, however, has to some extent bridged this gap, and today military history is “a broad church” characterized by a rich variety of approaches. Nevertheless, a number of profound challenges face historians wanting to do military history, including commercialization of the field, a strong tendency to Euro-Atlantic centrism, lack of representation, and a paucity of theoretical and methodological debates. Currently the most notable principal approaches to military history are operational military history, war and society (new military history), deconstructivist military history, and memory culture oriented military history.
Comparing the suitability of domestic spruce, beech, and poplar wood for high-strength densified wood
Authors: Jakob Matthias , Czabany Ivana , Veigel Stefan , Müller Ulrich , Gindl-Altmutter Wolfgang 
Published: May 2022

AbstractRegarding mechanics, wood is one of the most efficient materials available. Due to its unique combination of composite and cellular microstructure, it exhibits superb specific mechanical properties which exceed many man-made materials. However, concerning absolute mechanical properties, wood is often inferior to metals and novel engineered composites. Since many wood properties are strongly correlated with its density, densification is a promising pathway towards improved absolute mechanics. Spruce, beech and poplar wood were densified in a two-step process. First, amorphous wood polymers were partially extracted according to an alkaline (AL) and an organosolv (OS) protocol. Subsequently, partially delignified veneers were densified by hot pressing in tangential direction. After densification, average densities increased to 1.00–1.20 g cm−3. FTIR analysis confirmed chemical changes, mostly in the bands attributed to hemicelluloses and lignin, of chemically treated and hot-pressed veneers. To evaluate the modification process regarding mechanics, tensile and bending properties were characterized and revealed promising results. Compared to untreated control specimens, stiffness and strength tested in tension and bending improved, regardless of wood species and pretreatment. Regarding average tensile properties, the OS treatment improved stiffness, up to 40 GPa, whereas the AL treatment improved strength, up to 300 MPa. Set-recovery tests showed, that chemically treated and densified samples exhibited a better dimensional stability compared to H2O-soaked and compressed specimens. However, 24 h water soaking resulted in excessive thickness swelling. This might be a major drawback of partially delignified and densified wood and should be considered in a material selection process.
Efficacy and toxicity of vemurafenib and cobimetinib in relation to plasma concentrations, after administration via feeding tube in patients with BRAF-mutated thyroid cancer: a case series and review of literature
Authors: van Berge Henegouwen J. M. , van der Wijngaart H. , Zeverijn L. J. , Hoes L. R. , Meertens M. , Huitema A. D. R. , Devriese L. A. , Labots M. , Verheul H. M. W. , Voest E. E. , Gelderblom H. 
Published: May 2022

Abstract
Introduction
The combination of vemurafenib, a proto-oncogene B-Raf inhibitor (BRAFi) and cobimetinib, an inhibitor of mitogen-activated protein kinase kinase (MEKi) has shown to improve survival in patients with BRAF V600-mutated melanoma. BRAF mutations are also frequently detected driver mutations in other tumor types, including thyroid carcinoma. Since thyroid carcinoma is not a labeled indication for BRAF/MEKi, a cohort for patients with BRAF V600-mutated thyroid carcinoma was opened within the Drug Rediscovery Protocol (DRUP), a national ongoing pan-cancer multi-drug trial, in which patients receive off-label treatment with approved drugs based on their molecular tumor profile.

Results
Here, we present two patients with BRAF-mutated thyroid carcinoma, who were successfully treated with vemurafenib/cobimetinib administered via a feeding tube. Plasma concentrations of vemurafenib and cobimetinib were determined. A partial response was observed in both patients, but they experienced significant toxicity.

Conclusion
Our cases show that vemurafenib/cobimetinib treatment is effective in BRAF V600-mutated thyroid carcinoma, also when administered via a feeding tube. Although serious side effects occurred in both patients, we hypothesize that this was not attributable to the administration route. Therefore, administration of vemurafenib/cobimetinib by feeding tube is feasible and effective.

Trial registration
Clinical trial identification: NCT02925234.
Macronutrient quality index and cardiovascular disease risk in the Seguimiento Universidad de Navarra (SUN) cohort
Authors: Vanegas Paola , Zazpe Itziar , Santiago Susana , Fernandez-Lazaro Cesar I. , de la O Víctor , Martínez-González Miguel Ángel 
Published: May 2022

Abstract
Purpose
To assess the association between a multi-dimensional Macronutrient Quality Index (MQI) and the risk of cardiovascular disease (CVD) in a Mediterranean cohort.

Methods
Prospective analyses among 18,418 participants (mean age 36 years, 60.8% women) of the Seguimiento Universidad de Navarra (SUN) cohort. Dietary intake information was obtained through a validated semi-quantitative food-frequency questionnaire (FFQ). The MQI (expressing high-quality macronutrient intake) was calculated based on three previously reported quality indices: the Carbohydrate Quality Index (CQI), the Fat Quality Index (FQI), and the Healthy Plate Protein source Quality Index (HPPQI). Adherence to the Mediterranean diet (MedDiet) and Provegetarian Diet was evaluated using the Trichopoulou index and the score proposed by Martínez-González, respectively. CVD was defined as new-onset stroke, myocardial infarction, or CVD death.

Results
After a median follow-up time of 14 years (211,744 person-years), 171 cases of CVD were identified. A significant inverse association was found between the MQI and CVD risk with multivariable-adjusted HR for the highest vs. the lowest quartile of 0.60 (95% IC, 0.38–0.96; Ptrend = 0.024).

Conclusion
In this Mediterranean cohort, we found a significant inverse relationship between a multidimensional MQI (expressing high-quality macronutrient intake) and a lower risk of CVD.
The importance of the cerebroplacental ratio for the prognosis of neonatal outcome in AGA fetuses
Authors: Mecke L. , Ignatov A. , Redlich A. 
Published: May 2022

Abstract
Purpose
As a Doppler sonographic parameter, the cerebroplacental ratio (CPR) provides information about fetal hemodynamics and the redistribution of fetal blood volume in response to a metabolic change. The present study was undertaken to determine the extent to which CPR can be used as a valid parameter in routine obstetric assessment. We investigated whether CPR can be used to assess the neonatal outcome in appropriate for gestational age (AGA) fetuses and its association with secondary cesarean section due to fetal distress.

Methods
In this retrospective analysis 1739 pregnant women were admitted to the University Women‘s Clinic Magdeburg, Germany, between January 2016 and December 2017. Of them, 710 AGA fetuses were eligible for analysis. SGA fetuses with an estimated fetal weight < 10th percentile were excluded from the study. The AGA fetuses were divided in two groups based on the CPR: 669 fetuses showed a normal CPR ≥ 1.08; 41 fetuses showed a decreased CPR < 1.08.

Results
In our study cohort decreased CPR in AGA fetuses was associated with threefold increased rate of cesarean sections due to fetal distress (p < 0.001). Our data suggested that low CPR is a reliable predictor of an impaired neonatal outcome in AGA fetuses in terms of a lower birth weight, transfer to neonatology, longer length of hospitalization, and the presence of severe morbidity.

Conclusion
Decreased CPR in AGA fetuses correlated with impaired neonatal outcome and secondary cesarean section due to fetal distress. The potential role of CPR for obstetric screening should be investigated in further studies.
Observations from the March 2021 Thessaly Earthquakes: an earthquake engineering perspective for masonry structures
Authors: Sarhosis V. , Giarlelis C. , Karakostas C. , Smyrou E. , Bal I. E. , Valkaniotis S. , Ganas A. 
Published: May 2022

AbstractTwo strong earthquakes hit Thessaly region on March 3rd, 2021 (Mw = 6.3) and on March 4th, 2021 (Mw = 6.1). The epicentres of the earthquakes were located at approximately 23 and 29 km respectively NW of Larissa, one of the most populous cities in Greece. Several aftershocks followed thereafter. Although no injuries were recorded, several structures suffered significant damage close to the epicentre, while some others collapsed. Approximately 300 residents of the village of Damasi were transferred to temporary settlements and tents. The event occurred during the COVID19 lockdown and created significant stress and disruption to residents. This paper focuses on the earthquake swarm itself as well as the damages observed in residential buildings, schools, and churches in the earthquake-stricken region. The earthquakes mainly impacted low-rise domestic masonry buildings, while the more modern reinforced concrete structures built following the recent seismic regulations were almost unaffected. The typology of buildings in the region, together with photographs demonstrating the extent of damage are presented herein. Despite the rather satisfactory performance of modern buildings in recent earthquakes in Greece, the preliminary investigations from the Thessaly Earthquakes showed that there is still a significant level of vulnerability in existing masonry building stock constructed using traditional methods and materials. This issue could re-emerge in future earthquakes striking other rural areas of Greece, something that needs to be addressed systematically in the future.
Comparative Study of the CO2 Methanation Activity of Hydrotalcite-Based Nickel Catalysts Generated by Using Different Reduction Protocols
Authors: Müller Alexandra , Völs Pit , Störr Bianca , Mertens Florian 
Published: May 2022

AbstractParameters controlling the reduction of nickel hydrotalcite-based catalysts have been investigated in order to optimize the activity of the catalyst for CO2 methanation. Beside the variation of temperature and duration in the reduction process of the catalysts with hydrogen, two different reduction modes have been explored. The first one is the direct reduction of the dried uncalcined hydrotalcite-based precursor material whereas the second one is given by the reduction of the same type of precursor material but having been subjected to a calcination step prior to reduction. The corresponding kinetic measurements for the two principally different catalyst preparation schemes reveal that omitting the calcination step can largely be beneficial. Standard characterization data (XRD, BET, TG-FTIR, XPS) for the different catalytic materials will be presented.
Graphical abstract
Transdiagnostic Clinical Staging for Childhood Mental Health: An Adjunctive Tool for Classifying Internalizing and Externalizing Syndromes that Emerge in Children Aged 5–11 Years
Authors: Sawrikar Vilas , Macbeth Angus , Gillespie-Smith Karri , Brown Megan , Lopez-Williams Andy , Boulton Kelsie , Guestella Adam , Hickie Ian 
Published: May 2022

AbstractClinical staging is now recognized as a key tool for facilitating innovation in personalized and preventative mental health care. It places a strong emphasis on the salience of indicated prevention, early intervention, and secondary prevention of major mental disorders. By contrast to established models for major mood and psychotic syndromes that emerge after puberty, developments in clinical staging for childhood-onset disorders lags significantly behind. In this article, criteria for a transdiagnostic staging model for those internalizing and externalizing disorders that emerge in childhood is presented. This sits alongside three putative pathophysiological profiles (developmental, circadian, and anxious-arousal) that may underpin these common illness trajectories. Given available evidence, we argue that it is now timely to develop a transdiagnostic staging model for childhood-onset syndromes. It is further argued that a transdiagnostic staging model has the potential to capture more precisely the dimensional, fluctuating developmental patterns of illness progression of childhood psychopathology. Given potential improvements in modelling etiological processes, and delivering more personalized interventions, transdiagnostic clinical staging for childhood holds much promise for assisting to improve outcomes. We finish by presenting an agenda for research in developments of transdiagnostic clinical staging for childhood mental health.