bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boundaries and Things. A Metaphysical Study of the Brentano-Chisholm Theory
Authors: Nuñez Erices Gonzalo 
Published: September 2022

Abstract
The fact that boundaries are ontologically dependent entities is agreed by Franz Brentano and Roderick Chisholm. This article studies both authors as a single metaphysical account about boundaries. The Brentano-Chisholm theory understands that boundaries and the objects to which they belong hold a mutual relationship of ontological dependence: the existence of a boundary depends upon a continuum of higher spatial dimensionality, but also is a conditio sine qua non for the existence of a continuum. Although the view that ordinary material objects and their boundaries (or surfaces) ontologically depend on each other is correct, it does not grasp their asymmetric relationship: while the existence of a surface rigidly depends upon the existence of the very object it belongs to, the existence of a physical object generically depends upon having some surface. In modal terms, both are two kinds of de re ontological dependence that this article tries to distinguish.
On Ajdukiewicz's and Quine's Views on Ontology
Authors: Kosecki Artur 
Published: September 2022

Abstract
The aim of the paper is to analyze the views of Willard van Orman Quine and compare them with the views of Kazimierz Ajdukiewicz, an eminent philosopher from the Lvov-Warsaw School. I will argue that Ajdukiewicz's approach to ontology is deationary and, in that respect, similar to Quine's. In my analysis of these two ontological stances, I would like to refer to Price's deationist interpretation of Quine's views in order to highlight the similarity between Ajdukiewicz's views and Quine's stance on ontology. Additionally, as both Ajdukiewicz and Quine used a method of paraphrase, my paper also discusses similarities and differences in the methods used by these central representatives of two philosophical environments { Polish and Anglosphere.
The Epistemology of Understanding. A contextualist approach
Authors: Bachmann Marcus 
Published: September 2022

Abstract
This paper aims to provide a unifying approach to the analysis of understanding coherencies (interrogative understanding, e.g. understanding why something is the case) and understanding subject matters (objectual understanding) by highlighting the contextualist nature of understanding. Inspired by the relevant alternatives contextualism about knowledge, I will argue that understanding (in the above mentioned sense) inherently has context-sensitive features and that a theory of understanding that highlights those features can incorporate our intuitions towards understanding as well as consolidate the different accounts of how to analyse understanding. In developing a contextualist account of understanding, I will argue that an account of the features commonly taken to be central to understanding greatly benefits from a contextualist framework. Central to my analysis will be the claim that a person has to fulfill the function of a competent problem solver in order to qualify for the ascription of understanding. In addition to the theoretical elucidation of my contextualist approach to understanding, a demanding hypothetical scenario will be developed to function as a test case.
Steadfast Views of Disagreement are Incoherent
Authors: Tokhadze Tamaz 
Published: September 2022

Abstract
In this paper, I argue that Steadfast Views of peer disagreement - a family of views according to which standing firm in the face of peer disagreement can be rationally permissible are incoherent. First, I articulate two constraints that any Steadfast Views of disagreement should endorse: (i) Steadfastness's Core (ii) The Deference Principle. I show that (i) and (ii) are inconsistent: they cannot both be true. My argument, briefly put, is that one cannot rationally treat one's peer's opinion as unconditionally relevant to a hypothesis, H, but conditional on the supposition of a disagreement, irrelevant to H. Because Steadfast Views endorse a set of mutually inconsistent propositions, I conclude that Steadfast Views are incoherent
All Else Being Equal? Über Extension und Intension von Ceteris-Paribus- Gesetzen nach Lipton
Authors: Hoffmann Christian Hugo 
Published: September 2022

Abstract
Naturgesetze spielen eine zentrale Rolle in der Wissenschaftstheorie. Traditionell fokussierten Wissenschaftstheoretiker auf (Fundamental-)Gesetze der Physik, die man als zumindest wahre, universell gültige und kontrafaktische Konditionale stützende Aussagen ansah. Wiewohl diese Behauptung üuber Gesetze für den Bereich der Physik wohl zutre_en mag, scheinen doch die Gesetze in den Spezialwissenschaften andere Charakteristika aufzuweisen. Von ihnen wird behauptet, sie hätten Ausnahmen, seien also Ceteris-Paribus-Gesetze. Den Ausführungen von Peter Lipton in seinem Artikel "All Else Being Equal" folgend wird eine zweiteilige Forschungsfrage er örtert: Existieren genuine Ceteris-Paribus-Gesetze und, wenn ja, was ist darunter genau zu verstehen? Der Beitrag dieser Arbeit liegt insofern in einer kritischen Würdigung von Liptons Vorschlag als auch in seiner anschließenden Einordnung begrüundet
Against the Theistic Multiverse
Authors: Uckelman Sara L. 
Published: September 2022

Abstract
We argue that Kraay's "theistic multiverse" response to the objections to theism [11] is unsuccessful as it simply shifts the problems leveled against theism from the level of possible worlds to the level of possible universes. Furthermore, when we restate the objections at the level of possible universes, we can show how Kraay's conclusion about the uniqueness of the theistic multiverse is undermined.
The role and mechanism of tryptophan – kynurenine metabolic pathway in depression
Authors: Gong Xiaoli , Chang Rui , Zou Ju , Tan Sijie , Huang Zeyi 
Published: September 2022

Abstract
Major depressive disorder (MDD) is a common mental illness characterized by persistent low mood and anhedonia, normally accompanied with cognitive impairment. Due to its rising incidence and high rate of recurrence and disability, MDD poses a substantial threat to patients’ physical and mental health, as well as a significant economic cost to society. However, the etiology and pathogenesis of MDD are still unclear. Chronic inflammation may cause indoleamine-2,3-dioxygenase (IDO) to become overactive throughout the body and brain, resulting in excess quinolinic acid (QUIN) and less kynuric acid (KYNA) in the brain. QUIN’s neurotoxicity damages glial cells and neurons, accelerates neuronal apoptosis, hinders neuroplasticity, and causes depression due to inflammation. Therefore, abnormal TRP-KYN metabolic pathway and its metabolites have been closely related to MDD, suggesting changes in the TRP-KYN metabolic pathway might contribute to MDD. In addition, targeting TRP-KYN with traditional Chinese medicine showed promising treatment effects for MDD. This review summarizes the recent studies on the TRP-KYN metabolic pathway and its metabolites in depression, which would provide a theoretical basis for exploring the etiology and pathogenesis of depression.
An Emergent Apprehensional Epistemic Adverbial in Spanish
Authors: Persohn Bastian 
Published: September 2022

AbstractThe topic of this paper is an emergent Spanish adverbial,a lo peor, formed by analogy witha lo mejorʻmaybeʼ. This novel adverbial constitutes an instance of an apprehensional epistemic (Lichtenberk, Frantisek. 1995. Apprehensional epistemics. In Joan Bybee & Suzanne Fleischman (eds.),Modality in grammar and discourse, 293–327. Amsterdam: John Benjamins); that is, it expresses epistemic possibility together with a negative attitude towards the hypothetical state-of-affairs. We discuss its status as an emergent construction and develop a corpus-based descriptive approximation that extends previous notes on the adverbial by considering patterns of usage and aspects of syntax, as well as observations about diatopic and diaphasic variation. We further discuss the motivation for the coinage ofa lo peoras well as the exact process of analogy formation, applying both a language-internal perspective and a cross-linguistic one. Lastly, we compare our findings ona lopeor to typological observations on the functions and evolution of apprehensional epistemics.
Extracellular vesicles and particles impact the systemic landscape of cancer
Authors: Lucotti Serena , Kenific Candia M , Zhang Haiying , Lyden David 
Published: September 2022

AbstractIntercellular cross talk between cancer cells and stromal and immune cells is essential for tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a heterogeneous class of secreted messengers that carry bioactive molecules and that have been shown to be crucial for this cell–cell communication. Here, we highlight the multifaceted roles of EVPs in cancer. Functionally, transfer of EVP cargo between cells influences tumor cell growth and invasion, alters immune cell composition and function, and contributes to stromal cell activation. These EVP‐mediated changes impact local tumor progression, foster cultivation of pre‐metastatic niches at distant organ‐specific sites, and mediate systemic effects of cancer. Furthermore, we discuss how exploiting the highly selective enrichment of molecules within EVPs has profound implications for advancing diagnostic and prognostic biomarker development and for improving therapy delivery in cancer patients. Altogether, these investigations into the role of EVPs in cancer have led to discoveries that hold great promise for improving cancer patient care and outcome.
Congenital lipoid adrenal hyperplasia in a Saudi infant
Authors: Subki Siham Hussein , Wadea Mohammed Hussain Raghad , Al-Agha Abdulmoein Eid 
Published: September 2022

Summary
Congenital lipoid adrenal hyperplasia (CLAH) is characterized by a defect in the STAR protein-encoding gene that attenuates all steroidogenesis pathways. Herein, we present the first reported case in Saudi Arabia of a 46 XY, phenotypically female infant with an unfamiliar, darkened complexion compared to the family’s skin color. Based on the clinical and biochemical findings, CLAH was diagnosed and glucocorticoid replacement therapy was initiated. As a result, we suggest that pediatricians should always investigate the possibility of adrenal insufficiency when encountering unusual dark skin.

Learning points

Pediatricians should be prompted to rule out adrenal insufficiency in unexpectedly dark skin neonates.

In such patients, pediatricians should not wait until the neonate develops an adrenal crisis.

A low level of 17-hydroxyprogesterone does not always rule out the possibility of inherited adrenal gland disorders, and additional tests should be performed for early detection.
Sex differences in neural substrates of risk taking: Implications for sex-specific vulnerabilities to internet gaming disorder
Authors: Wang Lingxiao , Zheng Hui , Wang Min , Chen Shuaiyu , Du Xiaoxia , Dong Guang-Heng 
Published: September 2022

Abstract

Background and aims
Sex differences in internet gaming disorder (IGD) remain unknown. Investigating sex-specific neural features that underlie the core risk factor (i.e., risk-taking) of IGD would help in understanding sex-specific vulnerabilities to IGD and advance sex-specific treatments and prevention for IGD.

Methods
111 participants (28 IGD males, 27 IGD females, 26 recreational game user (RGU) males, 30 RGU females) completed a probability discounting task during fMRI scanning.

Results
First, among RGUs, males showed a higher risk-taking tendency and greater neural activation associated with risk/value evaluation for reward (the ventromedial prefrontal cortex (vmPFC), anterior cingulate cortex (ACC), left putamen) and smaller activation associated with cognitive control (the inferior frontal gyrus) than females during the contrast of risky-safe choices. Moreover, males showed a greater modulatory effect of risky choices on the connection from the vmPFC/ACC to the left putamen than females. Second, IGD males showed decreased activation in the vmPFC/ACC and left putamen compared to RGU males, whereas this decrease did not exist in IGD females.

Discussion
Males show a higher risk-taking tendency than females. Altered neural substrates associated with risky decision-making exist in IGD males but not in IGD females.

Conclusions
The present findings fill the gap in information on the behavioral and neural substrates underlying IGD among females and demonstrate that a high risk-taking tendency is a risk factor and core symptom only in IGD males but not in IGD females. It is necessary to design and adopt distinct treatments and prevention strategies for IGD in males and females.
Redefining object attachment: Development and validation of a new scale
Authors: David Jonathan , Norberg Melissa M. 
Published: September 2022

Abstract

Background and aims
Object attachment is the emotional bond or connection that we have with possessions. Although thought to be ubiquitous, when excessive, object attachment is presumed to contribute to compulsive buying and hoarding problems. Unfortunately, our understanding of this relationship has been limited by the constraints of existing object attachment measures. In this paper, we developed and validated a new self-report questionnaire, called the Object Attachment Security Measure (OASM).

Methods
We developed an item pool based on previous measures and consultation with 24 experts in the field. After piloting, we administered this measure to a large sample (Final N = 365), along with self-report measures of hoarding, compulsive buying, and previous object attachment measures.

Results
We found that the OASM distinguished between secure and insecure object attachment. Both subscales showed excellent internal consistency and test-retest reliability over a two-week period. Additionally, they demonstrated excellent convergent and divergent validity, and criterion validity with measures of hoarding and compulsive buying symptoms. We also found that insecure, but not secure object attachment, was uniquely related to hoarding and compulsive buying symptomology.

Discussion and conclusion
Our findings extend theoretical models, highlighting the role of insecure object attachment. Future research in both clinical and consumer behaviour fields should utilise the OASM, as reducing insecure object attachment and potentially encouraging secure object attachment could decrease maladaptive possession use and increase sustainable consumption.
Cost-Effectiveness research according to the type of catheter in the group of patients on routine hemodialysis program with permanent tunneled or temporary hemodialysis catheters
Authors: GÖZÜAÇIK RÜZGAR Asiye Aslı , AKGÜL Engin , ÖZHAN Abdulkerim , DURMAZ Selim , ASLAN Cenk , ÖNTAŞ Hakan 
Published: September 2022

Abstract
Background:
In this study, our aim was to conduct a cost/effectiveness research by determining the cost , in the patients who are in the routine hemodialysis program with a hemodialysis catheter, according to type of the catheter and the number of the days in which the catheters can be used actively.
Methods:
Between 2013 and 2020,patients with temporary hemodialysis catheters (Group 1 , n:81) and patients tunneled hemodialysis catheters (Group 2, n:205) were identified by scanning the hospital archive. The number of days in which the catheters were actively used was calculated according to the next catheter insertion or replacement date. Then, the permanent and temporary catheter fees paid by the governmentdetermined, according to the current Health Practices Communique (SUT) pricing that learnt from the hospital accounting department. Catheter cost per day was determined using the SPSS 22 program.
Results:
In the analysis made according to demographic characteristics, no significant difference was found between the groups in terms of gender (p=0.129). When the mean age of the patients was examined, no difference was found between the groups (p=0.085). No statistical difference was found between the groups in comorbid conditions: diabetes, hypertension, and coronary artery disease (p=0.219, p=0.129, p=0.822). The patency period was significantly higher in group 2 (p
Study of Variability in Seed Morphology, Screening of Seed Borne Fungi and Uses of Rarely Cultivated Indigenous Rice Landraces (Oryza sativa L.) of Kerala, India
Authors: Rachana K. , Sheikh Sana 
Published: September 2022

Background: Conservation is the key to sustainability. Kerala is known to be a host to number of traditional rice varieties, which are dying at a rapid pace. The first and foremost step in the conservation of traditional germplasm sources is to assess the various qualitative and quantitative features. Various scientists across the globe, have been studying the genetic diversity, morphological characteristics and fungal activities on rice since appreciable amount of time. This has proved to be helpful in sustenance and refinement of the rice varieties. Methods: Variability was accessed for quantitative and qualitative characters for 30 landraces. Notable variability was observed in the quantitative characters of the selected landraces. Highest variability was seen in ratio of length/breadth (l/b) without husk (25.55), followed by 50 kernel weight (25.51), kernel breadth without husk (21.21), ratio l/b with husk (19.19), kernel breadth with husk (17.90), kernel length without husk (16.58) and kernel length with husk (13.91). A dendrogram was generated by Ward’s method from the data acquired. Ten selected rice varieties were screened for seed borne fungi by standard blotter paper method. The percentage of disease incidence and percentage of frequency were calculated. Result: The rice varieties Choman and Ponnaryan showed highest percentage of disease incidence (100). Lowest percentage of disease incidence was seen in Kumkumashala and Gandhakashala. Highest frequency of occurrence was shown by Aspergillus sps. Other fungal species reported were Chaetomium sps., Curvularia sps., Helminthosporium sps., Unidentified sps. from Dematiaceae, Phoma sps. and Trichococcus sps.
​Effect of High Minimum Temperature and Enriched Night CO2 on Yield and Seed Quality of Black Gram (Vigna mungo) under Soil Plant Atmospheric Research (SPAR)
Authors: Guna M. , Ramanathan S.P. , Geethalakshmi V. , Chandrakumar K. , Kokilavani S. , Djanaguiraman M. 
Published: September 2022

Background: Black gram is a leguminous plant species. This pulse crop has been grown on the Indian subcontinent for a long time. Black gram a drought-resistant crop that grown both in the summer and the winter, usually in rotation with rice but occasionally in mixed farming. The objective of this research was to (i) quantify the short-term effects of high minimum temperature and enriched night CO2 (HMT and enCO2) on yield contribution factors and (ii) quantify seed quality parameters employing biochemical analysis. Methods: An investigation was carried out during summer 2021 and 2022 to evaluate the effect of high minimum temperature (ambient+3°C) and enriched night CO2 (600 ppm) (HMT and enCO2) on yield and seed quality parameters of black gram (Vigna mungo) under soil plant atmospheric research (SPAR) and ambient condition at Agro Climate Research Centre, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu with ten treatments which were replicated thrice. Result: Black gram yield and quality parameters were significantly (p=0.05) reduced under HMT and enCO2. Pooled data from two successive summer seasons revealed that stress from (i) 50 to 56 DAS (Days after sowing), the number of flowers dropped per plant significantly increased by 24% and pod setting percent decreased by 19.9% (ii) 43 to 49 DAS, grain yield and biomass/plant decreased by 25.4% and 16.2%, respectively. Seed quality parameters revealed that stress during 50 to 56 DAS, seed protein, total sugar content, polyphenols, calcium and iron decreased by 19.4%, 23.7%, 16.2%, 29.6% and 30.2%, respectively. The proline and phytic acid were statistically reduced by 53.9% and 59.1%, respectively stress during 50 to 56 DAS. Stress from 64 to 70 DAS, seed moisture content was significantly decreased by 32.1%. Overall, black gram yield and seed quality was negatively affected on two treatments: stress imposed from 43 to 49 DAS (T7) and stress imposed from 50 to 56 DAS (T8) (50% flowering to pod filling stage).
Analysis of Nutritional Value and Consumer Behavior Diversification of Milkfish (Chanos sp.) Products From Aquaculture Products By Packaging Modification In MSME Sukolilo, Surabaya
Authors: Patmawati Patmawati , Subekti Sri , Tjahjaningsih Wahju , Puspitasari Ida Ayu , R. P. Annisa Nur , Akmal A.H. Mohamad , Andini, W. Renyta , Rizky E Aliffiansyah 
Published: September 2022

Analisis nilai gizi dan prilaku konsumen merupakan aspek penting untuk peningkatan nilai jual dari produk baru. Perbaikan pada kemasan dan informasi nilai gizi adalah salah satu cara untuk meningkatkan branding sebuah produk dan meningkatkan nilai jual produk terutama di masa pandemic Covid-19. Oleh sebab itu, peneltian ini bertujuan untuk menganalisis nilai gizi dan perilaku konsumen pada produk otak-otak dan bandeng presto yang diolah oleh salah satu UMKM di Surabaya. Metode yang digunakan yaitu dengan analysis nilai gizi produk yang diolah oleh UMKM dlabolatorium dan analisis prilaku konsumen dengan menyebar kuisioner ke 50 responden dengan berbagai latar belakang Pendidikan. Hasil uji analisis nilai gizi kedua produk untuk bandeng presto yaitu kadar air sebesar 61%, kadar abu 7.64%, kadar lemak 6%, dan kadar protein 8.79%. Sedangkan untuk otak-otak bandeng mengandung kadar air 58.20%, kadar abu 3.12%, kadar lemak 13.42%, dan kadar protein 7.69%. Hasil analisis prilaku konsumen menunjukkan bahwa konsumen memilih produk yang menggunakan kemasan yang menarik yang dilengkapi kemasan sekunder dan primer dengan teknologi vakum dibandingkan dengan kemasan mika untuk produk bandeng presto atau daun pisang untuk produk otak. Pengaruh penggunaan kemasan juga tentunya akan bepengaruh terhadap nilai tambah dan umur simpan produk. Hasil riset menunjukan juga bahwa konsumen lebih memilih belanja online sebanyak 94% responden dengan mempertimbangan beberapa informasi seperti nilai gizi yang disajikan dalam kemasan. Oleh sebab itu, penjualan produk diversifikasi perikanan memupnya potensi pemasaran yang lebih luas menggunakan platform online dibanding penjualan langsung dipasar. Hal ini juga akan berpengaruh terhadap omzet dan peningkatan perekonomian UMKM jika terus didampingi dalam pengembangan penjualan secara digital.