bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can Patients With Controlled Rheumatoid Arthritis Taper Methotrexate From Targeted Therapy and Sustain Remission? A Systematic Review and Metaanalysis
Authors: Meng Charis F. , Rajesh Diviya A. , Jannat-Khah Deanna P. , Jivanelli Bridget , Bykerk Vivian P. 
Published: August 2022

ObjectiveTo determine the risk of not being able to sustain remission after tapering methotrexate (MTX) from targeted therapy in patients with controlled rheumatoid arthritis (RA).MethodsA systematic literature search was conducted in MEDLINE, Embase, and the Cochrane Library for studies reporting remission outcomes after tapering MTX from targeted therapies in RA. Full-text articles and abstracts reported in English were included. Metaanalyses were conducted using random-effects models. Forest and funnel plots were created.ResultsA total of 10 articles were included. Studies evaluated MTX being tapered from combination treatment with tumor necrosis factor inhibitors, tocilizumab, abatacept, and tofacitinib. A total of 9 studies used a randomized design and 1 was observational. Out of 10 studies, 3 focused on early RA (ie, < 1 yr). The MTX-tapering strategy was gradual in 2 studies and rapid in 8 studies. Follow-up ranged from 3 to 18 months in randomized trials and up to 3 years in the observational study. Our metaanalysis, which included 2000 participants with RA from 10 studies, showed that patients who tapered MTX from targeted therapy had a 10% reduction in the ability to sustain remission and an overall pooled risk ratio of 0.90 (95% CI 0.84-0.97). There was no heterogeneity (I2= 0%,P= 0.94). Our funnel plot indicated minimal publication bias.ConclusionPatients with controlled RA may taper MTX from targeted therapy with a 10% reduction in the ability to sustain remission for up to 18 months. Longer follow-up studies with attention to radiographic, functional, and patient-reported outcomes are needed. The risk of disease worsening should be discussed with the patient with careful follow-up and prompt retreatment of disease worsening.
HUBUNGAN PERILAKU GAYA HIDUP DENGAN PENINGKATAN TEKANAN DARAH PADA LANSIA DI GEREJA KATOLIK PAROKI SANTO PAULUS PASAR MERAH MEDAN TAHUN 2021
Authors: Fransiskus Sirait Josua , Derang Imelda , Novitarum Lilis 
Published: August 2022

Background: Hypertension or the condition of increasing systolic and diastolic blood pressure, namely 140 mmHg/≥90 mmHg, is susceptible to the elderly. Lifestyle can be a trigger factor for hypertension, such as diet, physical activity, smoking habits and sleep patterns. There is a relationship between lifestyle behavior and increased blood pressure.
Methods: This type of descriptive correlation research with cross sectional approach method, total sampling sampling technique, the number of samples is 60 people. The instruments used in this study were lifestyle questionnaires and observation sheets. Results: The results showed that there was a relationship between lifestyle behavior and increased blood pressure in the elderly at the Catholic Church of the Santo Paulus Parish, Pasar Merah Medan.
Conclusion: It can be concluded that there is a relationship between lifestyle behavior and increased blood pressure in the elderly at the St Paul's Parish Catholic Church, Pasar Merah Medan. It is hoped that the elderly will regularly control their blood pressure at the nearest health service such as health centers, posyandu and hospitals.
Evaluation of the High Altitude Lidar Observatory (HALO) methane retrievals during the summer 2019 ACT-America campaign
Authors: Barton-Grimley Rory A. , Nehrir Amin R. , Kooi Susan A. , Collins James E. , Harper David B. , Notari Anthony , Lee Joseph , DiGangi Joshua P. , Choi Yonghoon , Davis Kenneth J. 
Published: August 2022

Abstract. The NASA Langley Research Center High Altitude Lidar Observatory (HALO) is a multi-functional and modular lidar developed to
address the observational needs of NASA's weather, climate, carbon cycle,
and atmospheric composition focus areas. HALO measures atmospheric H2O
mixing ratios, CH4 mole fractions, and aerosol/cloud optical properties using the differential absorption lidar (DIAL) and high-spectral-resolution lidar (HSRL) techniques. In 2019 HALO participated in the NASA Atmospheric Carbon and Transport – America campaign on board the NASA C-130 to complement a suite of greenhouse gas in situ sensors and provide, for the first time, simultaneous measurements of column CH4 and aerosol/cloud profiles. HALO operated in 18 of 19 science flights where the DIAL and
integrated path differential absorption (IPDA) lidar techniques at 1645 nm were used for column and multi-layer measurements of CH4 mole fractions, and the HSRL and backscatter techniques were used at 532 and 1064 nm,
respectively, for retrievals of aerosol backscatter, extinction,
depolarization, and mixing layer heights. In this paper we present HALO's
measurement theory for the retrievals of column and multi-layer XCH4, retrieval accuracy, and precision including methods for bias correction and a comprehensive total column XCH4 validation comparison to in situ observations. Comparisons of HALO XCH4 to in situ-derived XCH4, collected during spiral ascents and descents, indicate a mean difference of 2.54 ppb and standard deviation (SD) of the differences of 16.66 ppb when employing 15 s along-track averaging (<3 km). A high correlation coefficient of R=0.9058 was observed for the 11 in situ spiral comparisons. Column XCH4 measured by HALO over regional scales covered by the ACT-America campaign is compared against in situ CH4 measurements carried out within the planetary boundary layer (PBL) from both the C-130 and B200 aircraft. Favorable correlation between the in situ point
measurements within the PBL and the remote column measurements from HALO
elucidates the sensitivity of a column-integrating lidar to CH4
variability within the PBL, where surface fluxes dominate the signal. Novel capabilities for CH4 profiling in regions of clear air using the DIAL technique are presented and validated for the first time. Additionally, profiling of CH4 is used to apportion the PBL absorption from the total column and is compared to previously reported IPDA cloud slicing techniques that estimate PBL columns using strong echoes from fair weather cumulus. The analysis presented here points towards HALO's ability to retrieve accurate and precise CH4 columns with the prospects for future multi-layer profiling in support of future suborbital campaigns.
Introducing SlideforMAP: a probabilistic finite slope approach for modelling shallow-landslide probability in forested situations
Authors: van Zadelhoff Feiko Bernard , Albaba Adel , Cohen Denis , Phillips Chris , Schaefli Bettina , Dorren Luuk , Schwarz Massimiliano 
Published: August 2022

Abstract. Shallow landslides pose a risk to infrastructure and residential areas. Therefore, we developed SlideforMAP, a probabilistic model that allows for a regional assessment of shallow-landslide probability while considering the effect of different scenarios of forest cover, forest management and rainfall intensity. SlideforMAP uses a probabilistic approach by distributing hypothetical landslides to uniformly randomized coordinates in a 2D space. The surface areas for these hypothetical landslides are derived from a distribution function calibrated on observed events. For each generated landslide, SlideforMAP calculates a factor of safety using the limit equilibrium approach. Relevant soil parameters are assigned to the generated landslides from log-normal distributions based on mean and standard deviation values representative of the study area. The computation of the degree of soil saturation is implemented using a stationary flow approach and the topographic wetness index. The root reinforcement is computed by root proximity and root strength derived from single-tree-detection data. The ratio of unstable landslides to the number of generated landslides, per raster cell, is calculated and used as an index for landslide probability. We performed a calibration of SlideforMAP for three test areas in Switzerland with a reliable landslide inventory by randomly generating 1000 combinations of model parameters and then maximizing the area under the curve (AUC) of the receiver operation curve. The test areas are located in mountainous areas ranging from 0.5–7.5 km2 with mean slope gradients from 18–28∘. The density of inventoried historical landslides varies from 5–59 slides km−2. AUC values between 0.64 and 0.93 with the implementation of single-tree detection indicated a good model performance. A qualitative sensitivity analysis indicated that the most relevant parameters for accurate modelling of shallow-landslide probability are the soil thickness, soil cohesion and the precipitation intensity / transmissivity ratio. Furthermore, we show that the inclusion of single-tree detection improves overall model performance compared to assumptions of uniform vegetation. In conclusion, our study shows that the approach used in SlideforMAP can reproduce observed shallow-landslide occurrence at a catchment scale.
Analysis Of Health Promotion Implementation In Pulmonary Tuberculosis Disease Control In Puskesmas Harapan Raya Kota Pekanbaru 2022
Authors: Fitriani Feby , Syukaisih Syukaisih , Septiani Winda 
Published: August 2022

Pulmonary Tuberculosis is an infectious disease caused by the bacterium Mycobacterium Tuberculosis which can attack various organs, especially the lungs. According to data from the Harapan Raya Health Center in 2020 there were 63 TB cases, in 2021 there were 73 TB cases, a total of 136 cases of people affected by pulmonary TB. This study aims to determine the implementation of health promotion in the control of pulmonary tuberculosis. This research uses a qualitative type of research with an in-depth observation and interview design. Informants were determined by purposive sampling technique Research variables are empowerment, advocacy and partnership. The research informants were 7 people, 1 key informant, namely the head of the Harapan Raya Health Center, 2 main informants, namely the person in charge of health promotion and the person in charge of tuberculosis. and 4 supporting informants, namely 2 general public people and 2 TB patients. Data collection was carried out in the work area of puskesmas Harapan Raya through in-depth interviews and observations. Data management techniques with triangulation. The results of this study indicate that empowerment is less than optimal due to the wide working area of ​​the Harapan Raya Health Center so that the empowerment is not evenly distributed, advocacy in TB control is still lacking because the budget for TB control still expects only a small amount of BOK funds and lack of support from community leaders in finding suspects TB case. Partnerships in TB control have been implemented. It is hoped that the Harapan Raya Health Center will further increase Health empowerment, advocacy and partnerships in tb control programs.
Factors Associated With Treatment-Related Changes in Voice Volume in People With Multiple Sclerosis
Authors: Crispiatico Valeria , Baldanzi Cinzia , Bertuletti Martina , Grassi Silvia , Tedeschi Francesca , Groppo Elisabetta , Rovaris Marco , Cattaneo Davide , Vitali Chiara 
Published: August 2022

ABSTRACT

BACKGROUND
Vocal disorders are frequent in people with multiple sclerosis (MS). Cognitive impairment, fatigue, depression, and other clinical characteristics can be associated with treatment effectiveness in rehabilitation. Finding baseline characteristics that identify those who are responding to treatment can help the clinical decision-making process, which can then help improve the effectiveness of voice treatment. We developed a model to identify factors associated with treatment-related improvement on voice intensity in people with MS.

METHODS
Data are from a randomized controlled trial of the effects of voice therapy. Forty-four people with MS were enrolled and randomized to receive Lee Silverman Voice Treatment LOUD, specifically addressing voice intensity, or conventional speech-therapy group. Voice intensity (dB) was measured during monologue before and after treatment and was used to differentiate those who responded (posttreatment voice intensity &gt; 60 dB) from those who did not. Possible associated factors were cognitive impairment, fatigue, depression, disability, and disease duration. Associations were assessed by univariate logistic regression and univariate and multivariate linear regressions.

RESULTS
Mean ± SD monologue voice intensity is improved in the whole sample (before rehabilitation: 51.8 ± 4.2 dB; and after rehabilitation 57.0 ± 6.5 dB; P &lt; .001), and 11 people with MS (27.5%) responded to treatment. Specificity of treatment was associated with the return to normal voice intensity (OR, 14.28; 95% CI, 12.17–309.56) and we found a linear association between voice improvement and the specificity of treatment (6.65 [SE = 1.54] dB; P &lt; .05). Moreover, the analysis revealed a nonlinear association between improvement and fatigue, suggesting increased benefits for people with MS with moderate fatigue. Other factors were not significantly associated with treatment effectiveness.

CONCLUSIONS
Moderate fatigue and the specificity of the intervention seem to be key factors associated with clinically relevant improvement in voice intensity even in people with MS with a high level of disability and long disease duration.
DESENHOS NO CHÃO E PINTURAS NO AR
Authors: Paula Débora Campos de 
Published: August 2022

A proposta deste artigo é discutir a importância do corpo como protagonista no processo de autoconhecimento e produção de saber, em consonância com um ambiente propício aos diálogos de corpo, à experiência e à reflexão. Pretende-se apontar algumas pistas que instiguem o leitor ao exercício imaginativo de deslocar o centro do pensamento de uma perspectiva hegemônica para um olhar pessoal e ao mesmo tempo coletivo de percepção do corpo-pensamento.1 O espaço no qual se desenvolveram estas investigações e de onde emergiram estas questões são as aulas de dança afro. O foco é a busca de uma dança em afroperspectiva que informe diferentes possibilidades de mover-se com base na relação com a ancestralidade, com a coletividade e com o autoconhecimento.
Case report of experience of misdiagnosis of Currarino syndrome as ovarian cyst
Authors: Le Aiwen , Xu Ya hong , Wang Zhonghai 
Published: August 2022

AbstractThe medical information was collected for Currarino syndrome. The patient had anal surgery for congenital anal stenosis when 2 years old. Clinical manifestations were pelvic cystic mass and low abdominal pain. The pelvic mass was found with a diameter of about 20 cm during the transabdominal exploration. At the second day after operation, the patient complained of neck pain. Neurosurgeon performed surgical treatment and diagnosed it as anterior sacral meningocoele. Currarino syndrome has female pelvic mass, sacral malformation, and congenital anorectal malformation, blindly puncture or drainage before operation should not be permitted.
Adaptive content suppression based on shared‐hidden‐layer convolutional autoencoder for blind image forensics
Authors: Rahmati Mohammad , Razzazi Farbod , Behrad Alireza 
Published: August 2022

SummaryDouble JPEG (DJPEG) compression detection is one of the crucial issues in detecting the presence of image forgery or tampering in blind image forensics. To address this challenge, this article investigates DJPEG compression detection in aligned and nonaligned tampering cases using adaptive image content removal based on a shared‐hidden‐layer convolutional autoencoder for preprocessing. Then the suppressed content images are classified with two convolutional neural networks (CNNs) in a parallel structure. These two networks are responsible for separating the small 64 × 64 single JPEG compression images from the DJPEG ones. The results indicate appropriate performance in the aligned and especially nonaligned cases. The detection possibility in the absence of alignment was investigated and favorable results were achieved. Since it is not possible to determine the exact values of the quality factor (QF) for optimal detection in some cases, we examined the network sensitivity to these QFs. The experimental results were satisfactory, especially in the aligned case. Comparing state‐of‐the‐art methods, we achieved a relative error reduction of about 69% in some cases. In addition, we determined the manipulated locations with high accuracy.
No difference in retinal fluorescence after oral curcumin intake in amyloid‐proven AD cases compared to controls
Authors: den Haan Jurre , Hart de Ruyter Frederique J. , Lochocki Benjamin , Kroon Maurice A.G.M. , Kemper E. Marleen , Teunissen Charlotte E. , van Berckel Bart , Scheltens Philip , Hoozemans Jeroen J. , de Kreeke Aleid van , Verbraak Frank D. , de Boer Johannes F. , Bouwman Femke H. 
Published: August 2022

AbstractIntroductionPrevious work has showed the in vivo presence of retinal amyloid in Alzheimer's disease (AD) patients using curcumin. We aimed to replicate these findings in an amyloid biomarker–confirmed cohort.MethodsTwenty‐six patients with AD (age 66 [+9], Mini‐Mental Status Examination [MMSE] ≥17) and 14 controls (age 71 [+12]) used one of three curcumin formulations: Longvida, Theracurmin, and Novasol. Plasma levels were determined and pre‐ and post‐curcumin retinal fluorescence scans were assessed visually in all cases and quantitatively assessed in a subset.ResultsVisual assessment showed no difference between AD patients and controls for pre‐ and post‐curcumin images. This was confirmed by quantitative analyses on a subset. Mean conjugated plasma curcumin levels were 198.7 nM (Longvida), 576.6 nM (Theracurmin), and 1605.8 nM (Novasol).DiscussionWe found no difference in retinal fluorescence between amyloid‐confirmed AD cases and control participants, using Longvida and two additional curcumin formulations. Additional replication studies in amyloid‐confirmed cohorts are needed to assess the diagnostic value of retinal fluorescence as an AD biomarker.
Secrecy rate optimization for dual‐functional radar‐communication system with energy receiver
Authors: Tong Xiao , Li Xin , Dong Fuwang , Wang Wei , Li Ang 
Published: August 2022

AbstractThis article studies the secrecy rate optimization in the downlink transmission of a dual‐functional radar‐communication system, under the simultaneous wireless information and power transfer (SWIPT) setting. Specifically, the base station (BS) simultaneously transmits information and energy signals while detecting the target, where the energy receiver (ER) also behaves as a potential eavesdropper. In order to ensure secure information transmission, we design the beamformer to avoid information leakage by maximizing the secrecy rate under the total transmit power budget, the received signal‐to‐noise ratio (SNR) target at the BS, and the received energy requirement of the ER. To deal with the non‐convexity of the cost function and constraints in the original problem, we first transform the problem into an equivalent semidefinite relaxation (SDR) version by linearizing the cost function with the introduced auxiliary variables. Thus, the off‐the‐shelf semidefinite programming (SDP) solver can be leveraged to obtain desired beamforming matrices, which is guaranteed to be rank‐1. To alleviate the computational costs of SDP, we further propose a sub‐optimal solution via the block coordinate descent method and the Taylor series expansion. Numerical results validate the effectiveness and superiority of the proposed algorithms.
Antibiotic utilisation in primary and revision total hip replacement patients: A registry linkage cohort study of 106 253 patients using the Australian Orthopaedic Association National Joint Replacement Registry
Authors: de Steiger Richard N. , Pratt Nicole L. , Gulyani Aarti , Duszynski Katherine M. , Inacio Maria C. , Graves Stephen E. , Smith Paul N. ,   For the Improving Joint Replacement Outcomes in Australia using National Data Linkage Study Working Group
Published: August 2022

AbstractPurposeInfection is a major complication following joint replacement (JR) surgery. However, little data exist regarding antibiotic utilisation following primary JR and how use changes with subsequent revision surgery. This study aimed to examine variation in antibiotic utilisation rates before and after hip replacement surgery in those revised for infection, revised for other reasons and those without revision.MethodsThis retrospective cohort analysis used linked data from the Australian Orthopaedic Association National Joint Replacement Registry and Australian Government Pharmaceutical Benefits Scheme. Patients were included if undergoing total hip replacement (THR) for osteoarthritis in private hospitals between 2002 and 2017. Three groups were examined: primary THR with no subsequent revision (n = 102 577), primary THR with a subsequent revision for reasons other than periprosthetic joint infection (PJI) (n = 3156) and primary THR with a subsequent revision for PJI (n = 520). Monthly antibiotic utilisation rates and prevalence rate ratios (PRRs) with 95% confidence intervals (CIs) were calculated in the 2 years pre‐ and post‐THR.ResultsPrior to primary THR antibiotic utilisation was 9%–10%. After primary THR, antibiotic utilisation rates were higher among patients revised for PJI (PRR 1.69, 95% CI 1.60–1.79) compared to non‐revised patients, while the utilisation rate was lower in patients revised for reasons other than infection (PRR 0.96, 95% CI 0.93–0.98). For those revised for infection, antibiotic utilisation post‐revision surgery was two times higher than those revised for other reasons (PRR 2.16, 95% CI 2.08–2.23). Utilisation of injectable antibiotics including, vancomycin, flucloxacillin and cephazolin was higher in those revised for PJI patients 0–2 weeks following surgery but not in those revised for other reasons compared to the non‐revised group.ConclusionsOngoing antibiotic utilisation after primary surgery may be an early signal of problems with the THR and should be a prompt for primary care physicians to refer patients to specialists for further appropriate investigations and management.
Prädiktive molekulare Diagnostik beim Mammakarzinom
Authors: Wild Peter J. , Denkert Carsten , Jackisch C. 
Published: August 2022

ZusammenfassungMit zunehmenden zielgerichteten Optionen zur Behandlung solider Tumoren wachsen für die Pathologie die Anforderungen an die prädiktive molekulare Diagnostik. Beim Mammakarzinom war das Erfordernis der Bestimmung genomischer prädiktiver Marker für zielgerichtete Therapien bisher überschaubar (Nachweis einer PIK3CA-Mutation beim endokrin vorbehandelten Luminaltumor und nur beim sekretorischen Mammakarzinom angezeigte Suche nach NTRK-Fusionen). Spätestens bei Nichtansprechen der Erst- bzw. Zweitlinienstandardtherapien ist eine Next-Generation-Sequencing-Panel-Diagnostik sinnvoll, um Resistenzmechanismen z. B. gegen die endokrine Therapie oder „cyclin-dependent kinase 4/cyclin-dependent kinase 6“ (CDK4/CDK6) abzuklären und Ansatzpunkte für in Entwicklung befindliche Therapien zu identifizieren. Die Interpretation sollte qualitätsgesichert gemäß internationalem Standard erfolgen und der interdisziplinären Tumorkonferenz zeitnah in einem transparenten und standardisierten Report zur Verfügung stehen.