bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multisystem Inflammatory Syndrome in Children and SARS-CoV-2 variants: a two-year ambispective multicentric cohort study in Catalonia, Spain.
Authors: Pino Rosa , Antoñanzas Jesús M , Paredes-Carmona Fernando , Perramon Aida , Rivière Jacques G , Coma Maria , Martínez-Mejías Abel , Ripoll Francesc , López Nuria , Conti Romina , Sala Pere , Ruiz Montserrat , Brio Sonia , García-Lorenzo Marc , Esteller Maria , Carreras-Abad Clara , Herrero-Hernando Carlos , Schneider Stephan Otto , Gatell Anna , Aguilar Isabel , Cantero Javier , Ruiz Gloria , Fenollosa Teresa , Lobato Zulema , Villalobos Pilar , Mora Emiliano , Anton Jordi , Visa-Reñé Nuria , Soler-Palacin Pere , Calavia Olga , Esqu Cristina , Guarch-Ibáñez Borja , García-García Juan José , Coma Ermengol , Fina Francesc , Prats Clara , Soriano-Arandes Antoni 
Published: September 2022

Abstract
Purpose
Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe disease temporarily related to SARS-CoV-2. We aimed to describe the epidemiological, clinical and laboratory findings of all the MIS-C cases diagnosed in children < 18 years-old in Catalonia (Spain) to study their trend throughout the pandemic.
Methods
Multicenter ambispective observational cohort study (April 2020-April 2022). Data were obtained from the COVID-19 Catalan surveillance system and from all the hospitals in Catalonia. We analyzed MIS-C cases regarding SARS-CoV-2 variants for demographics, symptoms, severity, monthly MIS-C incidence, ratio between MIS-C and accumulated COVID-19 cases, and associated rate ratios (RR).
Results
Among 555,848 SARS-CoV-2 infections, 152 children were diagnosed with MIS-C. Monthly MIS-C incidence was 4.1 (95%CI: 3.4–4.8) per 1,000,000 people, and 273 (95%CI: 230–316) per 1,000,000 SARS-CoV-2 infections (i.e., one case per 3,700 SARS-CoV-2 infections). During the Omicron period, MIS-C RR was 8.2 (95%CI: 5.7–11.7) per 1,000,000 SARS-CoV-2 infections, significantly lower (p < 0.001) than for previous variant periods, in all age groups. Median [IQR] age of MIS-C was 8 [4–11] years, 62.5% male, and 80.2% without comorbidities. Common symptoms were gastrointestinal findings (88.2%) and fever > 39oC (81.6%), nearly 40% had an abnormal echocardiography and 7% coronary aneurysm. Clinical manifestations and laboratory data were not different throughout the variant periods (p > 0.05).
Conclusions
The rate ratio between MIS-C cases and SARS-CoV-2 infections was significantly lower in the Omicron period for all the age groups, including those not vaccinated, suggesting that the variant could be the main factor for this shift in the MISC trend. Regardless of variant type, the patients had similar phenotypes and severity throughout the pandemic.
Multi-Coefficient Eigenmode Operation – Breaking Through 10°/hr Open-Loop Bias Instability in Wideband Aluminum Nitride Piezoelectric BAW Gyroscopes
Authors: Liu Zhenming , Wen Haoran , Ayazi Farrokh 
Published: September 2022

Abstract
This paper introduces a modification to the eigenmode operation of resonant gyroscopes. The so-called multi-coefficient eigenmode operation can improve cross-mode isolation due to spatially non-orthogonal imperfection, which is one of the causes of residual quadrature error in conventional eigenmode operation. A 1400µm annulus aluminum nitride (AlN) on Silicon bulk acoustic wave (BAW) resonator with gyroscopic in-plane bending modes at 2.98MHz achieves near 60dB cross-mode isolation when operated as a gyroscope using multi-coefficient eigenmode architecture. The as-born frequency mismatches in multiple devices are compensated by physical laser trimming as an alternative to the displacement feedback tunning mechanism. The demonstrated AlN piezoelectric BAW gyroscope shows a large open-loop bandwidth of 150Hz and a high scale factor of 9.5nA/°/s on a test board in a vacuum chamber. The measured angle random walk is 0.145°/√hr, and the bias instability is 8.6°/hr, showing significant improvement compared to the previous eigenmode AlN BAW gyroscope. The result from this paper proves that with multi-coefficient eigenmode operation, the piezoelectric AlN BAW gyroscopes can have a comparable noise performance as their capacitive counterpart while having the unique advantage of large open-loop bandwidth and not requiring large DC polarization voltages.
Efficacy of floating needles in the treatment of postpartum Urinary incontinence and pain: A systematic review and meta-analysis
Authors: Tang Min , Gong Shuang , Li Wanyi , Liu Zhitao , Liu Zicai , Han Dongmiao 
Published: September 2022

Abstract
Background: Postpartum pain and urinary incontinence are the most common postpartum sequelae, which can lead to postpartum anxiety and depression when severe, and seriously affect the quality of life of postpartum mothers. Floating needle as one of the Chinese medical treatments of the latest in recent years, studies have shown that floating needle for postpartum pain and stress incontinence (UI) has a positive effect, this study aimed to comprehensively and critically evaluate the available evidence on the effectiveness of floating needle in managing postpartum pain and UI, and provide the first evidence-based medical evidence for floating needle intervention for postpartum sequela.
Methods: Computer retrieval of Chinese databases: CNKI, Wanfang database, Chongqing VIP Full-text Database, China Biomedical Literature Database, and English database: PubMed, Embase, Web of Science, Cochrane Library, randomized controlled trial of the floating needle in the treatment of postpartum pain and urinary incontinence, search date: March 20, 2022. Keywords: floating needle, urinary incontinence, labor pain, postpartum pain, etc. Search all relevant articles in English and Chinese. Data extraction and quality evaluation were carried out for the literature that met the inclusion criteria, and a meta-analysis was conducted for the included literature data using RevMan5.4 statistical software.
Results： A total of 1194 women were included in 8 articles in Both Chinese and English, all of which were conducted in China, 6 of the articles were included in the meta-analysis. The floating needle is more effective in treating postpartum incontinence and pain than the control group[RR=1.33, 95%CI(1.18,1.5), P＜0.00001], and can significantly reduce the IC-IQ-SF score of postpartum incontinence and pain patients [MD=1.56, 95%CI(0.78,2.35), P＜0.0001], floating needle therapy can significantly reduce the amount of urine leakage in postpartum patients[MD=1.79, 95%CI(1.09,2.49), P＜0.00001].
Conclusions： Floating needles significantly reduced postpartum pain and improved stress urinary incontinence, but did not improve pelvic floor muscle strength. Like kegel, we encourage the use of floating needles in clinical practice as one of the routine treatments for postpartum sequelae.
High level of HDGF expression in hepatocellular carcinoma: a potential therapeutic target associated with prognosis and immune infiltration
Authors: Wang Jianlei , Chen Xiaolei , Xia Tong , Liu Zeyang , Song Jianping , Ma Delin , Liu Yanfeng 
Published: September 2022

Abstract
Background
Evaluations of hepatoma-derived growth factor (HDGF) expression may possess prognostic value for several cancers, including hepatocellular carcinoma (HCC). However, its functions and underlying mechanisms in HCC remain to be elucidated. The current study was designed to investigate the expression patterns of this protein, its prognostic value, immune characteristics and potential molecular mechanisms of HDGF in HCC.
Methods
Clinical and gene expression data were collected. The Kaplan–Meier method, time-dependent receiver operating characteristic (ROC) curves, and Cox regression analysis were used to analyze the prognostic value of HDGF. Differences in HDGF expression were analyzed using DESeq2 in R and gene ontology, KEGG, and GSEA were used to determine the biological functions of HDGF. Both the estimate and SsGSEA methods were used to analyze the immune infiltrates of HCC. Illumina human methylation 450 data and level 3 HTSeq-FPKM data from TCGA-LIHC cohort were used to determine the effects of DNA methylation on HDGF expression.
Results
HDGF was overexpressed in HCC and its expression correlated with T stage, pathological stage, histological grade, and AFP levels. Furthermore, we revealed the HDGF acts as an independent risk factor for overall survival in HCC and its expression is associated with the tumor-immune microenvironment and immune infiltration, especially in terms of cytotoxic, pDC and Th2 cell populations. Our data also suggests increased HDGF expression in HCC is associated with demethylation of its promoter region.
Conclusions
HDGF independently predicts unfavorable prognosis and regulates the immune microenvironment of HCC, identifying HDGF as a potential immunotherapeutic target for HCC.
Optimization of Organic-Inorganic Perovskite Solar Cell Layers
Authors: Hussain Chnar I. , Hassan Yousif M. , Abed Frh A. 
Published: September 2022

Abstract
Obtaining cheap Electronic Transparent Materials (ETM) and Hole Transparent Materials (HTM) is an important challenge for researchers in perovskite solar cells. we used the SCAPS software in order to determine the properties of CH3NH3SnI3-based solar cells with different ETM and HTM layers, such as (IGZO, SnO2, TiO2, ZnO) and (Spiro-OMeTAD, NiO, Cu2O, and CuO), respectively. Our results predict that among these ETMs, the SnO2 is the most promising to result in high photovoltaic (PV) efficiency in combination with Spiro-OMeTAD based HTM. In addition the perovskite absorber's thicknesses are optimized to achieve maximum photovoltaic efficiency. In order to increase efficiency, layer thickness in cell structures can be optimized by fixing the thickness of the first two layers while altering the thickness of the third. The perovskite solar cell's planar structure consists of ETM (SnO2)/perovskite absorber (CH3NH3SnI3) / HTM (Spiro-OMeTAD)/ and Gold (Au) as a back contact. Also, it improved the solar cell performance by optimizing the absorber thickness, which was 1 µm. With these considerations, the power conversion efficiency of 33.2698% is obtained. Also, we explore the effect of the defect at the perovskite/SnO2 interface on solar cell performance.
Oxidation behavior and outward diffusion of Al along oxide grain boundaries of FeCrAl alloys overdoped with Zr and Hf by means of Atom Probe Tomography (APT)
Authors: Daradkeh Samer I. , Boll Torben , Mousa Marwan S. , Sobola Dinara 
Published: September 2022

Abstract
It is generally accepted that the formation of α-Al2O3 scale on FeCrAl alloys is governed by inward oxygen transport along grain boundaries. However, it metal ion outward diffusion plays a role in the development of the oxide scales and their microstructural characteristics. This paper studies oxidation behavior and outward diffusion for iron-chromium alloys containing ~ 10 at. % aluminum, ~ 22 at. % Chromium, occurred when doped with an over-critical concentration of reactive elements, i.e. Zr and Hf. All samples were investigated after thermal exposure at 1100°C by Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Atom Probe Tomography (APT). As a result of the overdoping, a considerable increase in oxide growth, an increase in the depth of internal oxidation, and RE-oxide formation near and at oxide Grain Boundaries (GBs) were observed as a consequence of increased inward and outward diffusion. The effect of overdoping manifests itself differently depending on the RE type and amount due to different solubility, ionic size, and electronic structure. The overdoped sample with Zr is the retainment of the adhesion of alumina to the alloy after the first and second thermal exposure, contrary to Hf overdoping which leads to severe spallation after the second thermal exposure. And FeCrAl-Zr overdoped sample formed ZrO at oxide grain boundary and internal Al oxide.
Comparison of the effect of propolis vaginal gel and metronidazole oral tablet on wet smear test results in women suffering from trichomoniasis
Authors: Taghavian Shadi , Beiranvand Reza , Valiani Mahboubeh , Alian Siamak , Yekdaneh Afsaneh , Tehrani Hatav Gasemi , Zafarbakhah Azam , Brojeni Tahere Khalili 
Published: September 2022

Abstract
Background and objective: Trichomoniasis is the most common non-viral sexually transmitted infection. One of the methods for diagnosing trichomoniasis is a wet smear test. Propolis has anti-parasitic properties are due to its components, namely tannins, flavonoids, and volatile oils. The present study was performed to compare the effect of a vaginal gel containing propolis extract with that of a metronidazole oral tablet on the wet smear test results in women suffering from trichomoniasis.
Material and method: The present clinical trial was performed on 102 married non-pregnant women with trichomoniasis, who were referred to obstetrics and gynecology clinics in Isfahan from September 15 to January 20, 2020. The patients were assigned into two groups of intervention and control randomly. Both groups underwent treatment for 7 days. Wet smear was taken from the patients three times (i.e. initial visit, first follow-up, and second follow-up) and the samples were observed under Carl Zeiss single-lens microscope. Data were analyzed using SPSS (version 20) at a significance level of 0.05.
Results: Two groups did not differ significantly in terms of baseline characteristics. In the first post-treatment follow-up, the chance of a negative wet smear test result was 4.41 times greater in the intervention group than in the control group. Given the control of the baseline characteristics, this chance was 5.8 times greater. In addition, it was found that the chance of a negative wet smear test result in the second follow-up was affected by the wet smear test result in the first follow-up.
Conclusion: Based on the results of this study, it can be concluded that vaginal gel containing 7.5% propolis extract was more efficient than standard treatment in eradicating infection and preventing the recurrence of infection.
Nishanbaevite, KAl2O(AsO4)(SO4), a new As/S-ordered arsenate-sulfate mineral of fumarolic origin 1
Authors: Pekov Igor V. , Zubkova Natalia V. , Yapaskurt Vasiliy O. , Belakovskiy Dmitry I. , Britvin Sergey N. , Agakhanov Atali A. , Turchkova Anna G. , Sidorov Evgeny G. , Kutyrev Anton V. , Blatov Vladislav A. , Pushcharovsky Dmitry Yu. 
Published: September 2022

Abstract
A new mineral nishanbaevite, ideally KAl2O(AsO4)(SO4), was found in sublimates of the Arsenatnaya fumarole at the Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka, Russia. It is associated with euchlorine, alumoklyuchevskite, langbeinite, urusovite, lammerite, lammerite-β, ericlaxmanite, kozyrevskite, and hematite. Nishanbaevite occurs as long-prismatic or lamellar crystals up to 0.03 mm typically combined in brush-like aggregates and crusts up to 1.5 mm across. It is transparent, colourless, with vitreous lustre. Dcalc = 3.011 g cm− 3. Nishanbaevite is optically biaxial (–), α = 1.552, β ≈ γ = 1.567. The chemical composition (average of seven analyses) is: Na2O 3.79, K2O 8.01, CaO 0.10, CuO 0.21, Al2O3 30.08, Fe2O3 0.50, SiO2 1.62, P2O5 0.66, As2O5 32.23, SO3 22.59, total 99.79 wt.%. The empirical formula calculated based on 9 O apfu is: (K0.57Na0.41Ca0.01)Σ0.99(Al1.99Fe3+0.02Cu0.01)Σ2.02(As0.95S0.95Si0.09P0.03)Σ2.02O9. Nishanbaevite is orthorhombic, Pbcm, a = 15.487(3), b = 7.2582(16), c = 6.6014(17) Å, V = 742.1(3) Å3 and Z = 4. The strongest reflections of the powder XRD pattern [d,Å(I)(hkl)] are: 15.49(100)(100), 6.56(30)(110), 4.653(29)(111), 3.881(54)(400), 3.298(52)(002), 3.113(29)(121), and 3.038(51)(202, 411). The crystal structure, solved from single-crystal XRD data (R = 7.58%), is unique. It is based on the complex heteropolyhedral sheets formed by zig-zag chains of Al-centred polyhedra (alternating trigonal bipyramids AlO5 and octahedra AlO6 sharing edges) and isolated tetrahedra AsO4 and SO4. Adjacent chains of Al polyhedra are connected via AsO4 tetrahedra to form a heteropolyhedral double-layer. Its topological peculiarity is considered and compared with those in structurally related compounds. The (K,Na) site is located in the interlayer space between SO4 tetrahedra. The position of nishanbaevite among the arsenate-sulfates and their specific structural features are discussed. The mineral is named in honour of the Russian mineralogist Tursun Prnazorovich Nishanbaev (1955–2017).
An approach to chemical hardness through Shannon's entropy
Authors: Flores-Gallegos Nelson , Flores-Gómez Leonardo 
Published: September 2022

Abstract
Shannon's entropy is a concept that has been present in the field of theoretical chemistry since the early 70s, its versatilityhas permitted associate this concept with the chemical reactivity theory. In this work, we present a development that relates Shannon'sentropy with chemical hardness, the equations obtained were applied to a set of 1641 molecules, based on our results, it was possible to write a relationship between Shannon's entropy and the chemical hardness.
The clinic pathological and immunohistochemical features of breast carcinomas with signet-ring-cell differentiation
Authors: Zheng Jie , Liu Junlin , Yang Wan , Yao Jia , Guo Jiao , Liu Changqing 
Published: September 2022

Abstract
Background
This study investigated the clinicopathological features, immunophenotypic characteristics and differential diagnosis of primary breast carcinomas with signet ring cell differentiation, as well as differences in signet ring-like cell mucin traits.
Methods
A total of five cases of primary breast cancer with signet ring cell differentiation diagnosed and treated in The First People’s Hospital of Jingmen from January 2016 to December 2021 were collected. HE, immunohistochemical staining and AB-PAS staining were used to analyze.
Results
Although we have strictly selected all cases of primary breast cancer with signet ring cell differentiation, but there are differences in the arrangement of cells and the grading of nuclei. Immunohistochemical
Evaluate the necessity of autumn irrigation on salinized soil by considering change in soil physicochemical properties
Authors: Zhao Hang , Wu Jingwei , Li Changsen , Liu Yawen , Zhang Rui , Zhao Qiang 
Published: September 2022

Abstract
Agricultural irrigation is an effective way to control soil salinization in cold/arid regions. Specifically, autumn irrigation before soil freezes can inhibit the salt accumulation that occurs on the soil surface from freezing and thawing. However, changes in planting structure have resulted in farmers no longer conducting autumn irrigation, which may exacerbate the degree of soil salinization should this continue. Because autumn irrigation is very important for farmland management strategies, this study set up three management measures, autumn irrigation, no autumn irrigation and straw mulching, to evaluate the need to conduct autumn irrigation on salinized soil based on soil physicochemical properties. The results showed that autumn irrigation increased the soil water storage after thawing by 3.36×10− 2 m, soil salt storage increases were low, and the topsoil salinization grade did not change. However, with no autumn irrigation and straw mulching, the salt storage at 0–20 cm increased by 178.08% and 133.44%, respectively, and the topsoil became intensely salinized. Compared with that before freezing, the decrease in total soil porosity with autumn irrigation was smaller, but autumn irrigation exacerbated the fragmentation of large soil aggregates. The ≥ 0.3–100 µm pore size was reduced by 12.23% and 7.43% with no autumn irrigation and straw mulching, respectively, and the structure and function showed a degradation trend. Conversely, autumn irrigation improved soil water retention. The structural equation model further showed that autumn irrigation positively impacted the physicochemical properties of saline soil. This study provides new insights into mitigating salinization and developing farmland management measures.
Orelabrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Patients: Multi-center, Single-arm, Open-label, Phase 2 Study
Authors: Li Jianyong , Xu Wei , Zhou Keshu , Wang Tingyu , Yang Shenmiao , Liu Lihong , Hu Yu , Zhang Wei , Ding Kaiyang , Zhou Jianfeng , Gao Sujun , Xu Bing , Zhu Zunmin , Liu Ting , Zhang Huilai , Hu Jianda , Ji Chunyan , Wang Shunqing , Xia Zhongjun , Wang Xin , Li Yan , Song Yongping 
Published: September 2022

Abstract
Background
Orelabrutinib is a novel, small molecule, selective irreversible Bruton’s tyrosine kinase inhibitor. The aim of this study was to evaluate the efficacy as well as safety in patients with refractory or relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma (R/R CLL/SLL).
Methods
This is single-arm, multi-center, open-label, phase 2 study in 80 eligible Chinese patients, who were treated with monotherapy of orelabrutinib at 150 mg once daily. Overall response rate (ORR) that was evaluated by an independent review committee (IRC) was set as the study’s primary endpoint, with progression-free survival (PFS), overall survival (OS), and safety as the study’s major secondary endpoints.
Results
IRC-assessed ORR was 92.5% (74/80); complete response 21.3% (17/80), partial response 60.0% (48/80), partial response with lymphocytosis 11.3% (9/80). At a 32.3-month median follow-up (mFu), the median PFS had not been achieved, while the 30-month PFS rate and OS rate were 70.9% (95% confidence interval [CI], 59.5-79.6) and 81.3% (95% CI, 70.8-88.2), respectively. Orelabrutinib also revealed substantial response in patients with high prognostic risks: ORRs of patients carrying positive TP53 mutational status or del(17p), del(11q), as well as unmutated immunoglobulin heavy-chain variable region gene (IGHV) were 100%, 94.7%, and 93.9%, respectively. Most adverse events (AEs) were in low grade, with 86.8% of AEs being Grade 1 or 2. Nearly 67% of patients were still receiving orelabrutinib after almost a 3-year follow-up.
Conclusions
Orelabrutinib demonstrated compelling efficacy as well as safety profiles, with a noteworthy number of patients obtaining complete response in R/R CLL/SLL.
Trial registration
The study (NCT03493217) has been registered at ClinicalTrials.gov.