bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basophil activation test has high reproducibility and is feasible in the clinical setting
Authors: Jaumdally Hannah , Kwok Matthew , Jama Zainab , Hesse‐Lamptey Rochelle , McKendry Richard , Galvez Oliver , Daniel Yvonne , Santos Alexandra F. 
Published: November 2022

AbstractBackgroundThe basophil activation test (BAT) has high accuracy to diagnose peanut allergy and can reduce the need for oral food challenges (OFC); however, so far it has not been incorporated in clinical practice.MethodsWe assessed the reproducibility of BAT within the same laboratory and between two different laboratories and the feasibility of using BAT in the clinical setting.ResultsOne hundred and two children being assessed for peanut allergy were tested on BAT (72 allergic, 30 sensitized tolerant). There was little internal variation (coefficient of variation <15%) in the BAT and a very strong correlation (Rs > .95) between BAT performed across laboratories. The 2 BAT methods were strongly correlated but not interchangeable. In the cases of discrepancy, our in house BAT method was 100% accurate. BAT was feasible and well‐accepted by clinicians: no patient with positive BAT was referred for OFC, leading to reduction in the number of OFC required. Twenty one percent of patients who underwent OFC reacted to peanut. A negative BAT also encouraged the performance of OFC in sensitized children who would otherwise be considered allergic, 50% of whom did not react and incorporated peanut in the diet.ConclusionsThe BAT is a robust test that can reliably be transferred between laboratories; however, different BAT methods are not interchangeable. BAT was well integrated in the clinical decision‐making process in a specialized center.
The Dependency–Counterdependency Dynamic: Interactive Effects of System Justification and Power‐Distance Orientation on Radicalization against the Political System
Authors: Travaglino Giovanni A. , Moon Chanki 
Published: November 2022

System Justification Theory posits that individuals are less prone to engage in radical action against a system on which they depend. In the present research, we investigated how the association between system‐justifying tendencies and radical intentions is moderated by individuals' orientation towards power differentials, namely their “power distance.” A stronger power distance orientation implies that individuals perceive power differentials as a fixed feature of society, curtailing prospects for change. We hypothesized that, at lower levels of power distance orientation, system‐justification tendencies would be associated with reduced radical intentions. We contend this will occur because individuals feel dependent on a system perceived as malleable (dependency hypothesis). Conversely, at higher levels of power distance orientation, we expected system‐justification tendencies to be associated with stronger radical intentions. We argue that this effect reflects the rejection of dependency on a system perceived as fixed (counterdependency hypothesis). This dependency‐counterdependency dynamic was tested using a multigroup latent structural equation model and samples from four countries (NTotal = 2,502), South Korea, Italy, the United Kingdom, and the United States. Results were consistent with the hypothesized dynamic across all countries. Theoretical implications of the findings, limitations, and future research directions are discussed.
WLTOG: An optimization approach for wild large‐range target omnidirectional geolocation based on monocular PTZ camera
Authors: Zhou Xinxin , Yuan LinWang , Tang Hua , Huang Yi , Feng Ningyu , Wu Changbin 
Published: November 2022

AbstractThe pan‐tilt‐zoom (PTZ) cameras are increasingly popular in urban management and resource protection due to their omnidirectional coverage and reasonable cost. Traditionally, the research of monocular camera geolocation focuses on small‐range ones with a central projection camera under ideal conditions, making it challenging to meet the requirements of omnidirectional coverage and large‐range geolocation for PTZ cameras. In this article, a wild large‐range target omnidirectional geolocation (WLTOG) algorithm was proposed. Firstly, the WLTOG algorithm is used to transform the target in a single image to the camera's optical axis, thereby obtaining the camera posture value. After that, by using a high‐order overdetermined equation, it fits the nonlinear mapping relationship between multiple pairs of PTZ camera postures and the geospatial coordinates. At last, it realizes the bidirectional calculation between pixel coordinates and geospatial coordinates. The experimental PTZ camera is mounted on a communication tower in a wild environment. Therefore, this method can be utilized to construct an omnidirectional geolocation relationship that meets the requirements of omnidirectional geolocation within 945 m based on unknown accurate internal and external orientation elements. The WLTOG algorithm is conducive to the geometric measurement of video and GIS‐augmented video surveillance.
Urban growth modeling based on cellular automata with transition rules optimized using genetic fuzzy systems
Authors: Foroutan Ehsan , Delavar Mahmoud Reza , Pijanowski Bryan Christopher , Araabi Babak Nadjar 
Published: November 2022

AbstractThis article presents a new methodology for urban growth modeling by integrating cellular automata (CA) and genetic fuzzy algorithms. The urban growth phenomenon is a spatio‐temporal and continuous process that can be modeled by employing fuzzy logic as a framework for handling vagueness. Dependence upon an expert for assigning membership functions and rule weights has made the fuzzy logic approach rather subjective. Our proposed methodology overcomes this shortcoming by applying genetic algorithms to tune and optimize the fuzzy logic system and to make it expert independent. The optimization process encompasses a fuzzy membership function and weights for fuzzy rules. This model uses linguistic variables for defining CA transition rules and applies them to represent the non‐deterministic nature of urban growth. The proposed model is applied to simulate urban growth in the Tehran Metropolitan Area in Iran across time steps of 1988, 1999, and 2010 developed using Landsat TM and ETM+ images and a Digital Elevation Model. The first data pairs were employed for calibration of the model parameters, and the remainder of the data was used for validation of the model across time. The model was evaluated using a relative operating characteristic of 0.88 and a figure of merit statistic of 0.31, which quantifies the model goodness of fit.
A new bridge principle for the normativity of logic
Authors: Orilia Francesco 
Published: November 2022

AbstractLogic appears to be normative for rational belief. The thesis of the normativity of logic holds that indeed logic has such a normative status. Gilbert Harman has questioned it, thereby giving rise to what has been called “Harman's skeptical challenge”. MacFarlane has clarified that in order to answer this challenge and support the normativity of logic, one needs a “bridge principle” that appropriately connects logical entailments and norms for belief, as well as relevant desiderata for the evaluation of candidate bridge principles. Steinberger has identified a list of desiderata, on the basis of which he has proposed his own bridge principle and shown the inadequacy of previous proposals. This paper argues that Steinberger's list is in need of revision and his principle is unsatisfactory, and then puts forward a revised list of desiderata and a new bridge principle in support of the normativity of logic.
Frozen for combat: Quality of deep‐frozen thrombocytes, produced and used by The Netherlands Armed Forces 2001–2021
Authors: Noorman Femke , Rijnhout Tim W. H. , de Kort Bob , Hoencamp Rigo 
Published: November 2022

AbstractBackgroundThe Netherlands Armed Forces (NLAF) are using −80°C deep‐frozen thrombocyte concentrate (DTC) since 2001. The aim of this study is to investigate the effect of storage duration and alterations in production/measurement techniques on DTC quality. It is expected that DTC quality is unaffected by storage duration and in compliance with the European guidelines for fresh and cryopreserved platelets.Study Design and MethodsPre‐freeze and post‐thaw product platelet content and recovery were collected to analyze the effects of dimethyl sulfoxide (DMSO) type, duration of frozen storage (DMSO‐1 max 12 years and DMSO‐2 frozen DTC max 4 years at −80°C) and type of plasma used to suspend DTC. Coagulation characteristics of thawed DTC, plasma and supernatant of DTC (2× 2500 G) were measured with Kaolin thromboelastography (TEG) and phospholipid (PPL) activity assay.ResultsPlatelet content and recovery of DTC is ±10%–15% lower in short‐stored products and remained stable when stored beyond 0.5 years. Thawed DTC (n = 1724) were compliant to the European guidelines (98.1% post‐thaw product recovery ≥50% from original product, 98.3% ≥200 × 109 platelets/unit). Compared to DMSO‐1, products frozen with DMSO‐2 showed ±8% reduced thaw–freeze recovery, a higher TEG clot strength (MA 58 [6] vs. 64 [8] mm) and same ±11 s PPL clotting time. The use of cold‐stored thawed plasma instead of fresh thawed plasma did not influence product recovery or TEG‐MA.DiscussionRegardless of alterations, product quality was in compliance with European guidelines and unaffected by storage duration up to 12 years of −80°C frozen storage.
Influence of Strain History on Dynamic Strain Localization and Stress State During High-Rate Tensile Loading of Titanium Alloys: Experiments, Modeling, and Analytical Methods
Authors: Gour Govind , Thomson Daniel , Ramakrishnan Karthik Ram , Townsend David , Petrinic Nik , Pellegrino Antonio 
Published: November 2022

Abstract
The determination of the mechanical response of engineering materials subjected to high loading rates plays an important role in determining their performance and application. The high strain-rate tensile response of metals is usually investigated by means of the split-Hopkinson tension bar (SHTB) apparatus. The interpretation of the obtained results is, however, subjected to analogous stress and strain uniformity challenges present during quasi-static tensile experiments. Beyond the onset of necking, strains cease to be uniform along the gauge length and localize around the necking zone. Consequently, the nominal strain rate underestimates the effective strain rate experienced by the material. The analysis of the effective strain rate and stress state beyond the onset of necking has received considerable attention in the literature. Several research efforts have focused on the optimization of the geometry of specimens to be employed for the characterization of the dynamic tensile response using the SHTB. The present work investigates, systematically, the effects of strain history and adiabatic heating on the stress state during dynamic loading. A series of monotonic and various strain history experiments were conducted and analyzed. The diameter evolution, effective strain rate, and temperature histories were measured for all conducted experiments. Numerical simulations were carried out to examine the stress state during strain localization and to accurately reproduce engineering and local thermos-mechanical variables. The effectiveness of existing postnecking corrections for high-rate experiments is assessed. A modified postnecking correlation taking into account the effects of adiabatically induced thermal softening is proposed.
Durable spike-specific T cell responses after different COVID-19 vaccination regimens are not further enhanced by booster vaccination
Authors: Maringer Yacine , Nelde Annika , Schroeder Sarah M. , Schuhmacher Juliane , Hörber Sebastian , Peter Andreas , Karbach Julia , Jäger Elke , Walz Juliane S. 
Published: November 2022

Several COVID-19 vaccines are approved to prevent severe disease outcome after SARS-CoV-2 infection. Whereas induction and functionality of antiviral antibody response are largely studied, the induction of T cells upon vaccination with the different approved COVID-19 vaccines is less studied. Here, we report on T cell immunity 4 weeks and 6 months after different vaccination regimens and 4 weeks after an additional booster vaccination in comparison with SARS-CoV-2 T cell responses in convalescents and prepandemic donors using interferon-gamma ELISpot assays and flow cytometry. Increased T cell responses and cross-recognition of B.1.1.529 Omicron variant–specific mutations were observed ex vivo in mRNA- and heterologous-vaccinated donors compared with vector-vaccinated donors. Nevertheless, potent expandability of T cells targeting the spike protein was observed for all vaccination regimens, with frequency, diversity, and the ability to produce several cytokines of vaccine-induced T cell responses comparable with those in convalescent donors. T cell responses for all vaccinated donors significantly exceeded preexisting cross-reactive T cell responses in prepandemic donors. Booster vaccination led to a significant increase in anti-spike IgG responses, which showed a marked decline 6 months after complete vaccination. In contrast, T cell responses remained stable over time after complete vaccination with no significant effect of booster vaccination on T cell responses and cross-recognition of Omicron BA.1 and BA.2 mutations. This suggested that booster vaccination is of particular relevance for the amelioration of antibody response. Together, our work shows that different vaccination regimens induce broad and long-lasting spike-specific CD4
+
and CD8
+
T cell immunity to SARS-CoV-2.
Paleozoic evolution of the northern Laurentian margin: Evaluating links between the Caledonian, Ellesmerian, and Cordilleran orogens
Authors: McClelland* William C. , Strauss* Justin V. , Gilotti* Jane A. , Colpron* Maurice 
Published: November 2022

ABSTRACTThe passive margins of Laurentia that formed during Neoproterozoic–Cambrian breakup of the supercontinent Rodinia record subsequent histories of contraction and translation. This contribution focuses on the northern margin of Laurentia, where recent geologic and geochronologic data have provided new insight into the evolution of northern North America. The Laurentian margin in East and North-East Greenland records synorogenic sedimentation and deformation associated with the Caledonian orogeny—the Silurian to Devonian continent-continent collision between Baltica and Laurentia that followed closure of the northern tract of the Iapetus Ocean. The timing of ultrahigh-pressure metamorphism and simultaneous sinistral and dextral strike-slip faulting in North-East Greenland indicates that the Himalayan-style orogen persisted through the Devonian. In contrast, the Franklinian margin further west records sinistral strike-slip translation of allochthonous crustal blocks and arc fragments starting in the Ordovician–Silurian and culminating with the Devonian–Carboniferous Ellesmerian orogeny, the origin of which remains enigmatic. We suggest that Ellesmerian deformation was related to widespread transpression associated with northward motion of Laurentia during Acadian and Neo-Acadian deformation along the Appalachian margin rather than orthogonal ocean basin closure and microcontinent-continent collision. The Pearya terrane and North Slope subterrane of the Arctic Alaska terrane, separated from the Franklinian passive margin by the Petersen Bay fault and Porcupine shear zone, respectively, best preserve the Paleozoic translational and transpressional history of the northern Laurentian margin. These two major structures record a complex history of terrane accretion and translation that defines the Canadian Arctic transform system, which truncated the Caledonian suture to the east and ultimately propagated early Paleozoic subduction to the Cordilleran margin of western Laurentia.
Risk factors for community-acquired bacterial infection among young infants in South Asia: a longitudinal cohort study with nested case–control analysis
Authors: Connor Nicholas E , Islam Mohammad Shahidul , Mullany Luke C , Shang Nong , Bhutta Zulfiqar A , Zaidi Anita K M , Soofi Sajid , Nisar Imran , Panigrahi Pinaki , Panigrahi Kalpana , Satpathy Radhanath , Bose Anuradha , Isaac Rita , Baqui Abdullah H , Mitra Dipak K , Sadeq-ur Rahman Qazi , Hossain Tanvir , Schrag Stephanie J , Winchell Jonas M , Arvay Melissa L , Diaz Maureen H , Waller Jessica L , Weber Martin W , Hamer Davidson H , Hibberd Patricia , Nawshad Uddin Ahmed A S M , Islam Maksuda , Hossain Mohammad Belal , Qazi Shamim A , El Arifeen Shams , Darmstadt Gary L , Saha Samir K 
Published: November 2022

ObjectiveRisk factors predisposing infants to community-acquired bacterial infections during the first 2 months of life are poorly understood in South Asia. Identifying risk factors for infection could lead to improved preventive measures and antibiotic stewardship.MethodsFive sites in Bangladesh, India and Pakistan enrolled mother–child pairs via population-based pregnancy surveillance by community health workers. Medical, sociodemographic and epidemiological risk factor data were collected. Young infants aged 0–59 days with signs of possible serious bacterial infection (pSBI) and age-matched controls provided blood and respiratory specimens that were analysed by blood culture and real-time PCR. These tests were used to build a Bayesian partial latent class model (PLCM) capable of attributing the probable cause of each infant’s infection in the ANISA study. The collected risk factors from all mother–child pairs were classified and analysed against the PLCM using bivariate and stepwise logistic multivariable regression modelling to determine risk factors of probable bacterial infection.ResultsAmong 63 114 infants born, 14 655 were assessed and 6022 had signs of pSBI; of these, 81% (4859) provided blood samples for culture, 71% (4216) provided blood samples for quantitative PCR (qPCR) and 86% (5209) provided respiratory qPCR samples. Risk factors associated with bacterial-attributed infections included: low (relative risk (RR) 1.73, 95% credible interval (CrI) 1.42 to 2.11) and very low birth weight (RR 5.77, 95% CrI 3.73 to 8.94), male sex (RR 1.27, 95% CrI 1.07 to 1.52), breathing problems at birth (RR 2.50, 95% CrI 1.96 to 3.18), premature rupture of membranes (PROMs) (RR 1.27, 95% CrI 1.03 to 1.58) and being in the lowest three socioeconomic status quintiles (first RR 1.52, 95% CrI 1.07 to 2.16; second RR 1.41, 95% CrI 1.00 to 1.97; third RR 1.42, 95% CrI 1.01 to 1.99).ConclusionDistinct risk factors: birth weight, male sex, breathing problems at birth and PROM were significantly associated with the development of bacterial sepsis across South Asian community settings, supporting refined clinical discernment and targeted use of antimicrobials.
The social dimensions of community delivery of intermittent preventive treatment of malaria in pregnancy in Madagascar, Mozambique, Nigeria and the Democratic Republic of the Congo
Authors: Alonso Yara , Lusengi Wade , Manun’Ebo Manu F , Rasoamananjaranahary Aimée M , Rivontsoa Noroharifetra Madison , Mucavele Estêvão , Torres Neusa , Sacoor Charfudin , Okebalama Hope , Agbor Ugo James , Nwankwo Ogonna , Meremikwu Martin , Roman Elaine , Pagnoni Franco , Menéndez Clara , Munguambe Khátia , Enguita-Fernàndez Cristina 
Published: November 2022

IntroductionIntermittent preventive treatment in pregnancy with sulphadoxine pyrimethamine (IPTp) is a key malaria prevention strategy in sub-Saharan African countries. We conducted an anthropological study as part of a project aiming to evaluate a community-based approach to the delivery of IPTp (C-IPTp) through community health workers (CHWs) in four countries (the Democratic Republic of Congo, Madagascar, Mozambique and Nigeria), to understand the social context in order to identify key factors that could influence C-IPTp acceptability.MethodsA total of 796 in-depth interviews and 265 focus group discussions were undertaken between 2018 and 2021 in the four countries with pregnant women, women of reproductive age, traditional and facility-based healthcare providers, community leaders, and relatives of pregnant women. These were combined with direct observations (388) including both community-based and facility-based IPTp delivery. Grounded theory guided the overall study design and data collection, and data were analysed following a combination of content and thematic analysis.ResultsA series of key factors were found to influence acceptability, delivery and uptake of C-IPTp in project countries. Cross-cutting findings include the alignment of the strategy with existing social norms surrounding pregnancy and maternal health-seeking practices, the active involvement of influential and trusted actors in implementation activities, existing and sustained trust in CHWs, the influence of husbands and other relatives in pregnant women’s care-seeking decision-making, the working conditions of CHWs, pregnant women’s perceptions of SP for IPTp and persistent barriers to facility-based antenatal care access.ConclusionsThe findings provide evidence on the reported acceptability of C-IPTp among a wide range of actors, as well as the barriers and facilitators for delivery and uptake of the intervention. Overall, C-IPTp was accepted by the targeted communities, supporting the public health value of community-based interventions, although the barriers identified should be examined if large-scale implementation of the intervention is considered.
Improving psychosocial distress for young adolescents in rural schools of Pakistan: study protocol of a cluster randomised controlled trial
Authors: Hamdani Syed Usman , Huma Zill-E- , Malik Aiysha , Nizami Asad Tamizuddin- , Baneen Um ul , Suleman Nadia , Javed Hashim , Wang Duolao , van Ommeren Mark , Mazhar Samra , Khan Shahzad Alam , Minhas Fareed Aslam , Rahman Atif 
Published: November 2022

IntroductionEmotional problems are leading contributors to health burden among adolescents worldwide. There is an urgent need for evidence-based psychological interventions for young people. This study aims to evaluate the effectiveness of a school-based, group psychological intervention, Early Adolescent Skills for Emotions (EASE) developed by the WHO to improve psychosocial distress in Pakistani adolescents.Method and analysisA two-arm, single-blinded, cluster randomised controlled trial, with a wait-list control arm is being conducted in school settings of rural Pakistan. Forty eligible public-school clusters have been randomised (stratified by gender) on a 1:1 allocation ratio into intervention (n=20) and control arm (n=20). Following informed consent, 564 adolescents with psychosocial distress (Youth-reported Paediatric Symptoms Checklist, cut-off ≥28) from 40 schools have been enrolled into the trial (14±3 average cluster size) between 2 November 2021 and 30th November 2021. Participants in the intervention arm will receive EASE in 7-weekly adolescents and 3-biweekly caregivers group sessions in schools. The adolescent sessions involve the components of psychoeducation, stress management, behavioural activation, problem-solving and relapse prevention. Caregivers will receive training to learn and implement active listening; spending quality time and using praise as a strategy to help their children. The primary outcome is reduction in psychosocial distress at 3 months postintervention. Secondary outcomes include symptoms of depression and anxiety, caregiver–adolescent relationship and caregivers’ well-being. Outcomes will be assessed at baseline, immediate 1 week and 3-months postintervention. Qualitative process evaluation will explore barriers and facilitators to programme implementation in low-resource school settings.EthicsEthics approval has been obtained from Central Ethics Committee of University of Liverpool, UK, Ethics Review Committee of WHO Geneva and from the Institutional Review Board of Human Development Research Foundation (HDRF), Pakistan.DisseminationThe findings of the study will be disseminated by WHO and through peer-reviewed publications.Trial registration numberISRCTN17755448.