bluuebunny/crossref_metadata_2025_split huggingface dataset:
Silicone Granulomas of the Eyelids—A Case Series Illustrating a Distant Migratory Phenomenon
Authors: Neerukonda Vamsee K. , Lefebvre Daniel , Chatson George P. , Stagner Anna M. 
Published: September 2022

Purpose:
Exogenous silicone has been reported to migrate to anatomic sights far from an initial injection or implantation site; this phenomenon has been rarely described in the ocular adnexa, especially in the eyelids. We document 3 additional cases of distant migration of silicone implanted elsewhere in the body to the eyelids and review the prior literature on this uncommon event.

Methods:
A retrospective chart review of 3 patients was conducted along with analysis of diagnostic histopathology. A comprehensive review of the literature regarding dissemination or migration of silicone to the eyelids in patients with either silicone breast implants or silicone facial filler use was performed.

Results:
Cases of silicone migrating to the eyelids from silicone breast implants and silicone-based facial filler are outlined in Tables 1 and 2, respectively. There are 4 total reports of women with silicone breast implants, including the 2 described here, with evidence of migration of silicone to the eyelid. Similarly, 5 cases of silicone-based facial filler with resultant migration of filler to the eyelids were identified, including 2 of the cases presented in this report (1 patient had both silicone breast implants and silicone facial filler).

Conclusion:
Silicone is chemically inert, but is known to travel throughout the body, causing a resultant foreign body response in tissue that can adversely affect even the eyelids. Silicone has a relatively characteristic histologic appearance and diagnosis of silicone granuloma highlights the importance of obtaining a thorough clinical history, particularly regarding prior cosmetic injections or breast enhancement surgery. Foreign material/foreign body granuloma is important to consider in patients with deep eyelid nodules of unclear etiology.
Consistency of pediatric pain ratings between dyads: an updated meta-analysis and metaregression
Authors: Zhou Huaqiong , Albrecht Matthew A. , Roberts Pam A. , Porter Paul , Della Phillip R. 
Published: September 2022

Abstract
Accurate assessment of pediatric pain remains a challenge, especially for children who are preverbal or unable to communicate because of their health condition or a language barrier. A 2008 meta-analysis of 12 studies found a moderate correlation between 3 dyads (child–caregiver, child–nurse, and caregiver–nurse). We updated this meta-analysis, adding papers published up to August 8, 2021, and that included intraclass correlation/weighted kappa statistics (ICC/WK) in addition to standard correlation. Forty studies (4,628 children) were included. Meta-analysis showed moderate pain rating consistency between child and caregiver (ICC/WK = 0.51 [0.39–0.63], correlation = 0.59 [0.52–0.65], combined = 0.55 [0.48–0.62]), and weaker consistency between child and health care provider (HCP) (ICC/WK = 0.38 [0.19–0.58], correlation = 0.49 [0.34–0.55], combined = 0.45; 95% confidence interval 0.34–0.55), and between caregiver and HCP (ICC/WK = 0.27 [−0.06 to 0.61], correlation = 0.49 [0.32 to 0.59], combined = 0.41; 95% confidence interval 0.22–0.59). There was significant heterogeneity across studies for all analyses. Metaregression revealed that recent years of publication, the pain assessment tool used by caregivers (eg, Numerical Rating Scale, Wong-Baker Faces Pain Rating Scale, and Visual Analogue Scale), and surgically related pain were each associated with greater consistency in pain ratings between child and caregiver. Pain caused by surgery was also associated with improved rating consistency between the child and HCP. This updated meta-analysis warrants pediatric pain assessment researchers to apply a comprehensive pain assessment scale Patient-Reported Outcomes Measurement Information System to acknowledge psychological and psychosocial influence on pain ratings.
Detection of Colorectal Adenocarcinoma and Grading Dysplasia on Histopathologic Slides Using Deep Learning
Authors: Kim June , Tomita Naofumi , Suriawinata Arief A. , Hassanpour Saeed 
Published: September 2022

AbstractColorectal cancer is one of the most common types of cancer among men and women. The grading of dysplasia and the detection of adenocarcinoma are important clinical tasks in the diagnosis of colorectal cancer and shape the patients’ follow-up plans. This study evaluates the feasibility of deep learning models for the classification of colorectal lesions into four classes: benign, low-grade dysplasia, high-grade dysplasia, and adenocarcinoma. To this end, we develop a deep neural network on a training set of 655 whole-slide images of digitized colorectal resection slides from a tertiary medical institution and evaluate it on an internal test set of 234 slides, as well as on an external test set of 606 adenocarcinoma slides from The Cancer Genome Atlas database. Our model achieves an overall accuracy, sensitivity, and specificity of 95.5%, 91.0%, and 97.1% on the internal test set and an accuracy and sensitivity of 98.5% for adenocarcinoma detection task on the external test set. Our results suggest that such deep learning models can potentially assist pathologists in grading colorectal dysplasia, detecting adenocarcinoma, prescreening, and prioritizing the reviewing of suspicious cases to improve the turnaround time for patients with a high risk of colorectal cancer. Furthermore, the high sensitivity on the external test set suggests our model’s generalizability in detecting colorectal adenocarcinoma on whole slide images across different institutions.
Parallel use of pluripotent human stem cell lung and heart models provide new insights for treatment of SARS-CoV-2
Authors: Rudraraju Rajeev , Gartner Matthew J , Neil Jessica A. , Stout Elizabeth S. , Chen Joseph , Needham Elise J. , See Michael , Mackenzie-Kludas Charley , Yang Lee Leo Yi , Wang Mingyang , Pointer Hayley , Karavendzas Kathy , Abu-Bonsrah Dad , Drew Damien , Sun Yu Bo Yang , Tan Jia Ping , Sun Guizhi , Salavaty Abbas , Charitakis Natalie , Nim Hieu T. , Currie Peter D , Tham Wai-Hong , Porrello Enzo , Polo Jose , Humphrey Sean J. , Ramialison Mirana , Elliott David A. , Subbarao Kanta 
Published: September 2022

AbstractSARS-CoV-2 primarily infects the respiratory tract, but pulmonary and cardiac complications occur in severe COVID-19. To elucidate molecular mechanisms in the lung and heart, we conducted paired experiments in human stem cell-derived lung alveolar type II (AT2) epithelial cell and cardiac cultures infected with SARS-CoV-2. With CRISPR- Cas9 mediated knock-out of ACE2, we demonstrated that angiotensin converting enzyme 2 (ACE2) was essential for SARS-CoV-2 infection of both cell types but further processing in lung cells required TMPRSS2 while cardiac cells required the endosomal pathway. Host responses were significantly different; transcriptome profiling and phosphoproteomics responses depended strongly on the cell type. We identified several antiviral compounds with distinct antiviral and toxicity profiles in lung AT2 and cardiac cells, highlighting the importance of using several relevant cell types for evaluation of antiviral drugs. Our data provide new insights into rational drug combinations for effective treatment of a virus that affects multiple organ systems.One-sentence summaryRational treatment strategies for SARS-CoV-2 derived from human PSC models
Performance analysis of a cloud-based network analytics system with multiple-source data aggregation
Authors: Fowdur Tulsi Pawan , Babooram Lavesh 
Published: September 2022

Purpose
The purpose of this paper is geared towards the capture and analysis of network traffic using an array ofmachine learning (ML) and deep learning (DL) techniques to classify network traffic into different classes and predict network traffic parameters.

Design/methodology/approach
The classifier models include k-nearest neighbour (KNN), multilayer perceptron (MLP) and support vector machine (SVM), while the regression models studied are multiple linear regression (MLR) as well as MLP. The analytics were performed on both a local server and a servlet hosted on the international business machines cloud. Moreover, the local server could aggregate data from multiple devices on the network and perform collaborative ML to predict network parameters. With optimised hyperparameters, analytical models were incorporated in the cloud hosted Java servlets that operate on a client–server basis where the back-end communicates with Cloudant databases.

Findings
Regarding classification, it was found that KNN performs significantly better than MLP and SVM with a comparative precision gain of approximately 7%, when classifying both Wi-Fi and long term evolution (LTE) traffic.

Originality/value
Collaborative regression models using traffic collected from two devices were experimented and resulted in an increased average accuracy of 0.50% for all variables, with a multivariate MLP model.
Individual ambidexterity after entrepreneurial failure in COVID-19 pandemic times: the influence of current employment status
Authors: Boz Semerci Anil 
Published: September 2022

PurposeThis study highlights the business failure experienced in pandemic times, its impact on entrepreneurs' perception of failure and the reciprocal relationship between entrepreneurs' perception of failure and individual ambidexterity.Design/methodology/approachThe study provides empirical evidence on interpreting the long-term outcomes of business failure in pandemic times and develops a deeper insight by utilizing a two-year research design (time 1: 2020 and time 2: first half of 2021). It draws on data from 200 entrepreneurs who experienced business failure in the coronavirus disease 2019 (COVID-19) pandemic times which is a global crisis.FindingsThe results revealed that both challenge and hindrance appraisals of failure are associated with individual ambidexterity over time. Self-efficacy and social valuation of re-entry decisions are mediators between hindrance appraisal and individual ambidexterity on both time 1 and time 2. Moreover, there is a positive reciprocal relationship between self-efficacy and ambidexterity throughout the two time periods. In regard to participants' current employment status, hindrance appraisal, self-efficacy and perceptions of ambidexterity linkages were found to be significantly different in terms of unemployment and employment.Originality/valueTo the best of the author's knowledge, it is the first time that the individual ambidexterity of failed entrepreneurs was explored after hard times in the pandemic. It comprehensively helps to understand the importance of cognitive appraisal of hard times and identifies the perceptional and behavioral consequences of failure in entrepreneurship.
Ethnic chambers of commerce and co-creation of value: a synthesis of cultural and networking competencies
Authors: Elliot Esi , Smith Robert Spencer , Bicen Pelin 
Published: September 2022

Purpose
The purpose of this paper is to explore and understand how Chambers of Commerce enhance networking among ethnic small businesses and enable the co-creation of value. This study contributes to extant research through the emergence of the concept of cultural networking competence. This study highlights how Chambers of Commerce in the USA ensures the continuation, growth and replication of ethnic small businesses through cultural networking competence.

Design/methodology/approach
This study investigates the research question by conducting qualitative research and adopting an interpretive approach of investigation in the Hispanic Chamber of Commerce in Chicago. Subjects were recruited using purposive sampling techniques via community links.

Findings
Findings show the existence of four different types of value in line with Holbrook’s typology of value – utilitarian, social, emotional and altruistic value. Because these values are culturally related, this study regards these values as cultural networking competence, which differs from general networking competence due to its focus on culture. With cultural networking competence, ethnic firms benefit from access to new domains, the creation of new opportunities, an improved effectiveness in achieving objectives beyond their own ethnic networks and the resources of other actors that can be leveraged for wider impact.

Originality/value
This study contributes to extant research through the emergence of the concept of cultural networking competence. This study highlights how Chambers of Commerce in the USA ensures the continuation, growth and replication of ethnic small businesses through cultural networking competence.
Community‐wide trait adaptation, but not plasticity, explains ant community structure in extreme environments
Authors: Ibarra‐Isassi Javier , Handa Ira Tanya , Lessard Jean‐Philippe 
Published: September 2022

Abstract

Quantifying trait–environment associations can help elucidate the processes underpinning the structure of species assemblages. However, most work has focused on trait variation across rather than within species, meaning that processes operating at the intraspecific levels cannot be detected. Incorporating intraspecific trait variation in community‐wide analyses can provide valuable insights about the role of morphological adaptation and plasticity on species persistence and the composition of ecological communities.

Here, we assessed geographical variation in the direction (i.e. adaptation) and strength of selection, and the magnitude of plasticity, by examining community‐wide trait variation in ant communities along an environmental gradient spanning 9° latitude in Quebec, Canada. Specifically, we measured 9 morphological traits related to foraging strategies, resource use and thermal regulation at 20 locations across temperate and boreal forests. We then examined how the mean and variance of these traits varied along temperature and precipitation gradients. Moreover, we examined how these trait–environment relationships varied across levels of organization, from individual workers (intraspecific) to colonies (intraspecific) and species (interspecific).

We observed changes in mean trait values along environmental gradients, but very little change in variance. Specifically, we observed a decrease in the mean length of antennae and an increase in the mean eye length from mild (warm and wet) to more extreme environments (cold and dry). These shifts in trait means were mostly coordinated across organizational levels (i.e. worker, colony and species). We also observed a general increase in trait variance from mild to extreme environments, but only at the species level.

Our findings suggest that stressful environmental conditions exert a strong selection pressure on ant morphology causing shifts in optimal trait values. These adaptations may enable persistence at the northern edge of the boreal forest and therefore influence the composition of these ant communities. Specifically, ants with large eyes and short antennae are overrepresented at the transition zone between the boreal forest and the tundra, possibly representing an adaptation to these more open habitats. Our study demonstrates that combining spatial and community‐wide intraspecific functional trait data provides a promising way forward to gain new insights on trait adaptations and processes underpinning community structure along environmental gradients.

Read the free Plain Language Summary for this article on the Journal blog.
The MK2 cascade mediates transient alteration in mGluR‐LTD and spatial learning in a murine model of Alzheimer's disease
Authors: Privitera Lucia , Hogg Ellen L. , Lopes Marcia , Domingos Luana B. , Gaestel Matthias , Müller Jürgen , Wall Mark J. , Corrêa Sonia A. L. 
Published: September 2022

AbstractA key aim of Alzheimer disease research is to develop efficient therapies to prevent and/or delay the irreversible progression of cognitive impairments. Early deficits in long‐term potentiation (LTP) are associated with the accumulation of amyloid beta in rodent models of the disease; however, less is known about how mGluR‐mediated long‐term depression (mGluR‐LTD) is affected. In this study, we have found that mGluR‐LTD is enhanced in the APPswe/PS1dE9 mouse at 7 but returns to wild‐type levels at 13 months of age. This transient over‐activation of mGluR signalling is coupled with impaired LTP and shifts the dynamic range of synapses towards depression. These alterations in synaptic plasticity are associated with an inability to utilize cues in a spatial learning task. The transient dysregulation of plasticity can be prevented by genetic deletion of the MAP kinase‐activated protein kinase 2 (MK2), a substrate of p38 MAPK, demonstrating that manipulating the mGluR‐p38 MAPK‐MK2 cascade at 7 months can prevent the shift in synapse dynamic range. Our work reveals the MK2 cascade as a potential pharmacological target to correct the over‐activation of mGluR signalling.
Mechanical stress‐induced hemolysis of bovine blood is donor‐dependent
Authors: Li Zengji , Hu Jie , Kamberi Marika , Rapoza Richard J. 
Published: September 2022

AbstractIntroductionIn vitro hemolysis testing is an essential method for assessing the hemolytic potential of blood pumps, but has poor reproducibility. Further investigations are needed to determine the sources and extent of variability and to find a practical way to reduce the variation.MethodsA small volume blood circulating loop driven by a Centrimag pump was established to provide relatively higher hemolysis readouts within a short run time and to be able to sequentially perform multiple repeated hemolysis tests in a working day.ResultsThe repeatability with this system was demonstrated as the %RSD at 4.3% for the NIH or MIH from three repeated tests using the same blood. The bovine blood from different randomly selected donors was tested and gave more than a two‐fold difference in NIH results (0.077 vs. 0.032 g/100 L) under the same testing conditions and same pump. This wide variation in hemolysis using bovine blood from different donors happened repeatedly. More importantly, it was observed that the difference in hemolysis test results using the blood drawn from the same donor on multiple days was narrow although the native hematocrits varied. The %RSD of NIH values obtained on five different days were 6.8%, 8.4%, 11.5%, and 7.8% for donor‐specific blood from donors 1 to 4, respectively.ConclusionThe study results indicate that the mechanical stress‐induced hemolysis behavior is donor‐dependent. It has been also demonstrated that the reproducibility of in vitro hemolysis testing can be improved when the blood drawn from same donor is used.
Having time to oneself in times of extended togetherness: Solitude experiences during the COVID‐19 pandemic
Authors: Choi Yoonseok , Pauly Theresa , Zambrano Garza Elizabeth , Broen Tiana , Gerstorf Denis , Hoppmann Christiane A. 
Published: September 2022

AbstractThis study investigated how time to oneself (solitude) is experienced under conditions of extended togetherness with household members during the pandemic. Both structural (living arrangements) and qualitative characteristics (relationship quality and conflict) were examined for their association with solitude desire and daily solitude–affect links. We expected that people living with others and those with more high‐quality as well as those with more conflictual relationships would report better affect quality when experiencing solitude. A Canadian adult lifespan sample (N = 141; Mage = 38.43 years, SDage = 17.51; 81% female; 73% White; data collected from April to August 2020) provided information on household size and relationship characteristics and completed repeated daily life assessments of solitude desire, solitude, and affect. Findings show that living arrangements were not associated with an increased desire for solitude or better affect quality from solitude. Individuals reporting higher relationship quality and individuals reporting more conflict showed more favorable affect quality on days when they had time in solitude than individuals reporting lower quality relationships and lower conflict. Findings add to the growing solitude literature by delineating who seeks and benefits from solitude, and under what conditions.
Genetic enhancement, human extinction, and the best interests of posthumanity
Authors: Rueda Jon 
Published: September 2022

AbstractThe cumulative impact of enhancement technologies may alter the human species in the very long‐term future. In this article, I will start showing how radical genetic enhancements may accelerate the conversion into a novel species. I will also clarify the concepts of ‘biological species’, ‘transhuman’ and ‘posthuman’. Then, I will summarize some ethical arguments for creating a transhuman or posthuman species with a substantially higher level of well‐being than the human one. In particular, I will present what I shall call the Principle of the Best Interests of Posthumanity, which states that the enhancement of the human and transhuman species must be directed towards the creation of a posthuman existence that is substantially more valuable than its predecessors. I suggest that human extinction may be considered, within that principle, as one of the best interests of posthumanity. Finally, I will develop three objections that make that principle unattractive and that show that pursuing a full‐blown programme of posthuman evolution is ethically flawed.
The sanctity of life as a sacred value
Authors: Clarke Steve 
Published: September 2022

AbstractThe doctrine of the sanctity of life has traditionally been characterised as a Judeo‐Christian doctrine that has it that bodily human life is an intrinsic good and that it is always impermissible to kill an innocent human. Abortion and euthanasia are often assumed to violate the doctrine. The doctrine is usually understood as being derived from religious dogma and, as such, not amenable to debate. I show that this characterisation of the doctrine is problematic in a number of ways, and I go on to rethink the doctrine. In doing so I follow in the footsteps of Ronald Dworkin, who offered a characterisation of the doctrine in his 1993 Life's Dominion, drawing on a conceptualisation of sacredness that is radically different from standard ones and not dependent on religious dogma. I'll argue that although Dworkin's efforts have much to recommend, his conceptualisation of sacredness is inadequate. Dworkin attempted to reconceptualise sacredness ‘from the armchair’. Here I explain how sacred values are thought of in anthropology and psychology and argue that the sanctity of human life should be understood in the same way. I'll explain how doing so allows us to resolve a number of conceptual problems that bedevil standard characterisations of the doctrine of the sanctity of life. I'll also consider the possibility of a compromise over the sanctity of human life, and as a consequence, compromise over the permissibility of abortion and euthanasia. I'll argue that such compromise is possible, albeit difficult to achieve.