bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating an emotion coaching programme for parents of young adolescents attending Child Adolescent Mental Health Services (CAMHS) in New Zealand: protocol for a multi-site feasibility trial including co-design with service users.
Authors: Mansoor Zara , Stanley James , Fortune Sarah , Havighurst Sophie , Bell Elliot 
Published: October 2022

Abstract

Background
Early adolescence is a time of increased vulnerability for the development of common mental health conditions such as anxiety and depression (internalising outcomes). Current treatments such as Cognitive-Behavioural Therapy and antidepressant medication are focused on the individual and have small effect sizes, particularly in complex clinical settings. Parents are an important and under-utilised resource in treating these conditions in young adolescents. Teaching parents how to respond to their young person’s emotions can improve emotion regulation and reduce internalising outcomes. One emotion-focused programme for parents of this age group is Tuning in to Teens (TINT). This study aims to investigate the impact of TINT in the clinical setting of publicly funded Child and Adolescent Mental Health Services (CAMHS) in New Zealand.
Methods
The trial will evaluate the feasibility of a two-arm multi-site randomised control trial (RCT). Participants will be 10–14-year-olds referred to Child and Adolescent Mental Health Services (CAMHS) in Wellington, New Zealand with anxiety or depression, and their parents or guardians. The two arms will be usual care in CAMHS or, usual care plus parents attending a TINT group programme. TINT groups will be facilitated by CAMHS clinicians who have been trained in the programme and will be delivered over 8 weekly sessions. Prior to the RCT, a co-design methodology will be used with service-users to determine how the impact of this programme should be measured. Primary feasibility outcomes will be recruitment and retention of participants, acceptability of the intervention for service-users and clinicians, and acceptability of outcome measures.
Discussion
There is a need to improve outcomes for treatment of adolescent anxiety and depression. TINT is a promising programme to enhance outcomes for those accessing mental health services by providing targeted support to parents of adolescents. This trial will inform whether a full RCT is feasible to evaluate TINT. Including service-users in the design will increase its relevance in this setting.
Trial registration:
Australian New Zealand Clinical Trials Registry (ACTRN): ACTRN12622000483752. Registered 28 March 2022.
Tunable Plasmon-Phonon Modes in Nonlinear-Graphene-hBN Heterostructures
Authors: Heydari Mohammad Bagher , Karimipour Majid , Shirkolaei Morteza Mohammadi 
Published: October 2022

Abstract
In this paper, the analytical expressions are derived for the study of Hybrid Surface Phonon-Plasmon-Polaritons (HSP3) in a nonlinear graphene-based structure with hexagonal Boron Nitride (hBN) layers. The numerical results show that the propagation features of HSP3 can be varied by changing the chemical potential, the relaxation time, and the nonlinear coefficient. Due to the existence of hBN layers in the proposed structure, the investigation is done in two frequency ranges: the upper and lower Reststrahlen bands. The obtained results represent that two kinds of hybrid modes propagate outside the upper and lower Reststrahlen bands which we call “higher and lower modes”. However, only one propagating mode is seen inside the upper or lower Reststrahlen band. A high value of FOM=98 is reported at the frequency of 45 THz (inside the upper Reststrahlen band) for the chemical potential of 0.35 eV. The authors believe that the analytical study done on HSP3 in this paper can help the researchers to design innovative structures such as sensors in the mid-infrared region.
Economic considerations of breeding for polledness versus disbudding in beef cattle
Authors: Oliveira Ingrid Pereira Pinto , Maciel Silel Vinicius Simões Andrade , Carvalho Caio Victor Damasceno , Costa Raphael Bermal , de Camargo Gregório Miguel Ferreira 
Published: October 2022

Abstract
The domestication of animals has rendered horns less necessary for survival. Moreover, the use of polled and disbudded animals is interesting in order to avoid injuries of animals and handlers, among other advantages. We therefore conducted a comparative economic analysis of different disbudding techniques versus selection for polledness in Nelore cattle, the main beef breed of tropical systems in Brazil. Three scenarios for obtaining animals without horns were simulated and their costs were evaluated: disbudding with hot iron, disbudding with caustic paste, and phenotypic selection for polled animals. Price quotations of the materials were obtained in different states of the country and averaged. An initial frequency of horned animals of 92.16% was obtained based on the records of the Brazilian Association of Zebu Breeders. Selection was found to be the least-cost method. This result differs from intensive production systems of dairy cattle in which disbudding continues to be the least-cost technique. The main explanation is the lack of difference in the price of Nelore semen from polled and horned bulls. Phenotypic selection for polled animals is the least-cost methos and it is in accordance with welfare practices. Care should be taken regarding the intensive use of few polled breeding animals in order to avoid inbreeding depression in other traits.
Detecting Long-term Characteristics of Marine Heatwaves (1982–2021) in the Indonesian Waters
Authors: Beliyana Erlin , Ningsih Nining Sari , Gunawan Sekar Ramdanira , Tarya Ayi 
Published: October 2022

Abstract
In this paper, we investigate the characteristics of marine heatwaves (MHWs) (i.e. frequency, maximum intensity, and duration of occurrences) in Indonesian waters and the mechanisms underlying the formation of MHWs generated by local forcing. The study utilizes the remote sensing data from National Oceanic and Atmospheric Administration (NOAA) Optimum Interpolation Sea Surface Temperature (OISST) dataset for SST and the European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis data (ERA5) for net surface heat flux components (shortwave radiation, longwave radiation, sensible heat flux, and latent heat flux), wind speed, and total cloud cover. The data covered a period within the last 40 years (1982–2021) during the warm (1982–2007) and cold (2008–2021) phases of the Pacific Decadal Oscillation (PDO) and were processed by statistical analysis methods. This study clearly reveals the highest average frequency and duration of MHWs in the Indonesian waters which were around 3–5 times a year and 10–20 days, respectively, occurring during the cold phase of PDO. Meanwhile, the highest maximum intensity of MHWs in the Indonesian waters was around > 1.5°C during the warm phase of PDO (El Niño dominated in Indonesia) generated by the local net surface heat flux. The most dominant contributors of net surface heat flux were high shortwave radiation (heat gain) and low latent heat flux (heat loss) through the evaporation process, thus keeping the ocean warm. Moreover, this study highlights the highest maximum intensity of MHWs which could reach > 3°C along western Sumatra to southern Java and waters around Papua when El Niño and positive Indian Ocean Dipole (pIOD) occur together. In contrast, the lowest maximum intensity of MHWs in the Indonesian waters occurred when La Niña was happening simultaneously with negative IOD (nIOD).
3D printed flexible anatomical models for left atrial appendage closure planning and comparison of deep learning against radiologist image segmentation
Authors: Ravi Prashanth , Burch Michael , Farahani Shayan , Liu Isabella Y. , Wilkinson Kayleigh E. , Feinstein Matthew A. , Chokshi Shivum , Sousa Patrick , Lopes Patricia , Byrd Stephanie , Kondor Shayne , Chepelev Leonid L. , Rybicki Frank J. , Giannopoulos Andreas A. , Costea Alexandru 
Published: October 2022

Abstract
Background:
Medical 3D printing is being increasingly employed for pre-procedural planning and simulation. One important application is in occluder device sizing for left atrial appendage (LAA) closure. Studies have demonstrated clinical utility of 3D printed anatomical models for LAA closure. Artificial intelligence-based segmentation has been applied to multiple cardiovascular diseases, including to LAA segmentation. However, to our knowledge, there has not been a comparison of artificial intelligence-based deep learning segmentation (DLS) where there was a clinical 3D printed model of the left atrium and appendage.
Methods:
Thirty-nine patients had 3D printed models requested by the interventional cardiologist (IC). Standard segmentation (SS) was performed by a trained engineer and approved by a cardiovascular imager (CI). The models were 3D printed using flexible resin and desktop inverted vat photopolymerization technology. The effort expended throughout the workflow was meticulously documented. Thirty-four of the 39 patients underwent left atrial appendage occlusion using the 3D printed model for device sizing. The 34 patients who underwent a procedure using the 3D printed model were followed for 6 months for major adverse events, device embolization, procedure related myocardial infarction (MI), procedural stroke, new pericardial effusion, pericardial effusion requiring intervention, surgical conversion, and peri-procedural death. All 39 patients also underwent DLS using a commercial software and metrics including segmentation time, segmented volume, DICE index were assessed compared to the SS. A Bland-Altman and regression/correlation analysis was also conducted.
Results:
The mean SS time was 72.3 minutes whereas the mean DLS time was 3.5 minutes. The DLS closely matched the SS with a mean DICE index of 0.96. The average number of devices attempted was 1.3. The DLS was highly correlated with the SS volume data (r = 0.99). Bland-Altman analysis showed a negative bias (-5.31%) in the volume difference data. There were no long-term complications in the 34 patients who underwent procedure using the 3D printed model for occluder device sizing.
Conclusions:
We have successfully demonstrated the performance of a commercial DLS algorithm compared to CI approved SS for left atrial appendage occluder device sizing using a clinical 3D printed model.
Conflict resolution for aspect-oriented static modeling
Authors: Pinciroli Fernando , Zeligueta Laura , Palma Marcelo 
Published: October 2022

Abstract
Separation of concerns allows the achievement of important benefits in all phases of the software development life cycle. Thus, it is possible to take advantage of this technique with the consequent improvement of the understanding of the models. However, conflicts of different types may be produced when concerns are composed to form a single system, due to the same fact of having them managed separately. Additionally, this problem is increased by the number of people needed to deal with large projects. This article is focused on the composition of concerns in structural models, in which each concern is realized by an individual class diagram. The same classes are present in several diagrams, although with different members and relationships, due to the specific nature of the concern they realize. In systems of medium to high complexity, the intervention of more than one analyst is required and, because of the working styles each one might have, many other conflicts could arise when all diagrams are composed into only one. In this paper, we present an experience in which four systems analysts elaborated six class diagrams which belong to a single system and we expose the conflicts that occurred after the composition of the diagrams. After the analysis and classification of the conflicts, a set of modeling agreements and recommendations was elaborated in order to reduce them. Then, the models were rebuilt and composed again, with a significant decrease in the number of conflicts detected after the second composition.
Understanding youths’ concerns about climate change: a cross-cultural qualitative study of a generation’s ecological burden and resilience
Authors: Thomas Isaiah , Martin Andrés , Wicker Antoine , Benoit Laelia 
Published: October 2022

Abstract
Background
Climate change has been shown to have long-term effects on mental health, yet, to date, there have been few studies on how children and adolescents experience and respond to ecological changes and how and why they engage in climate action. We explored empirically young people’s views about climate change and how distinct cultural contexts influence individual climate action.
Methods
We invited children and adolescents (ages 7 to 18) and their caregivers from the general population in the United States and France to participate in semi-structured focus groups. We recruited 74 participants, 39 in the U.S. (33 children and adolescents, 6 parents) in the U.S. and 35 in France (32 children and adolescents, 3 parents). Focus groups with participants centered on their emotions, beliefs, and actions around climate change. We analyzed the focus group data and developed themes via grounded theory and symbolic interactionism approaches.
Results
Many participants described experiencing anger, hopelessness, guilt, and sadness in response to climate change, and a smaller number endorsed significant anxiety symptoms; many described frustration about needing to fix the mistakes of earlier generations. Younger participants frequently misunderstood the purpose of their parents’ eco-conscious behaviors unless they were provided with age-appropriate explanations. Participants described a spectrum of experiences when trying to discuss climate change with peers and family, ranging from genuine support to apathy to hostility. Between the two samples, U.S. participants experienced more conflict with adults about climate change than French participants, but French participants expressed a greater lack of political agency compared to U.S. participants. Participants in both samples expressed a relatively balanced view of climate action, recognizing the significance of individual actions while acknowledging the limits of their power in the face of systemic issues. Some participants found hope and empowerment through climate action and building communities around it.
Conclusions
Discussing with children and adolescents what adults are doing to combat climate change can provide reassurance, model prosocial behaviors, and inspire their own investment in climate action. In comparing the U.S. and France, it is evident that adults seeking to support the psychological well-being of young people should both support their concerns and actions around climate change and create avenues for young people to meaningfully engage in climate action.
Fluoxetine attenuates pain-like and depression-related behaviors via reducing neuroinflammation and synaptic deficits in bone cancer mice
Authors: Jiang Li , Yang Xu-li , Qian Yue , Huang Si-min , Mao Yan-ting , Huang Yu-lin , Xu Rui , Zhu Hui-jie , Gu Xiao-ping , Ni Kun , Sun Yu-e , Ma Zheng-liang 
Published: October 2022

Abstract

Background Bone cancer patients are often accompanied with pain and depression, which seriously affects their quality of life and survival time. Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to be effective not only in reducing depression-like behaviors but also in alleviating cancer pain. However, the specific mechanisms involved remain obscure. Methods Bone cancer mice were treated with fluoxetine for 7 consecutive days after the formation of pain and depression symptoms. Neuroinflammation and synaptic changes at the basolateral amygdala (BLA) after treatment were examined with western blotting, immunofluorescence and Golgi-Cox staining. Results Compared with the tumor group, fluoxetine significantly improved the mechanical allodynia and sugar water preference ratio, and reduced the immobility time of forced swimming. In addition, we found fluoxetine had an inhibitory effect on reactive glial cells and neurotoxic glial cells of bone cancer pain (BCP) mice. Meanwhile, fluoxetine could improve synaptic function in the bone cancer mice basolateral amygdala regions. Conclusions Fluoxetine can effectively alleviate pain-like and depression-related behaviors in BCP model. The concerned mechanisms may be related to reducing neurotoxic glial cells activation and promoting synapse formation at BLA.
The Impact of Human Capital on Green Economic Efficiency: Evidence from 280 Prefectural Cities in China
Authors: Peng Weibin , Xu Jiaxin , He Zhengxia 
Published: October 2022

Abstract
Balancing the relationship between economic growth and resources and the environment is the key to China's green development. Human capital is considered to be the supporting condition for promoting green development. In recent years, the state has attached great importance to talent cultivation, and major cities have actively introduced relevant policies for talent in various fields. However, there is a lack of relevant studies on whether and how the human capital can impact green economic efficiency (GEE) at the city level. In this paper, we examine the impact of human capital on GEE in each prefecture-level city and test the mechanism of action based on the super-efficient SBM model to calculate GEE, including non-desired output using panel data of 280 prefecture-level cities in China from 2003 to 2019. The results of the baseline regression study show that the improvement of human capital level contributes to the GEE of prefecture-level cities. Among the control variables, economic development level, foreign direct investment, city size and science and technology innovation level positively affect GEE, while industrialization and environmental regulation negatively affect GEE. The mechanism of action study results indicate that industrial structure upgrading plays a positive moderating role. That is, industrial structure upgrading can strengthen the effect of human capital on GEE, which is further clarified.
Opposite effects of positive and negative symptoms on resting-state brain networks in schizophrenia
Authors: Wang Xinrui , Chang Zhao , Wang Rong 
Published: October 2022

Abstract
Schizophrenia is a severe psychotic disorder clinically characterized by positive and negative symptoms, but their neural bases remain poorly understood. Here, we utilized a nested-spectral partition (NSP) approach to detect hierarchical modules in resting-state brain functional connectivity networks in schizophrenia patients and healthy controls, and we studied the dynamic transitions of segregation and integration as well as their relationships with clinical symptoms. Schizophrenia brains showed a more stable global integrating process and a more variable segregating process, thus maintaining higher segregation, especially in the limbic system. Attention systems were associated with hallucinations, and default-mode network (DMN) and control systems were related to avolition. In a machine-learning model, NSP-based features outperformed classical graph measures at predicting positive and negative symptom scores. Multivariate analysis confirmed that positive and negative symptoms had opposite effects on dynamic segregation and integration of brain networks. Gene ontology analysis revealed that the effect of negative symptoms on brain networks was related to autistic, aggressive and violent behavior; the effect of positive symptoms was associated with hyperammonemia and acidosis; and the interaction effect was correlated with abnormal motor function. Our findings could contribute to the development of more accurate diagnostic criteria for positive and negative symptoms in schizophrenia.
Trace elements zinc, copper, magnesium, and rubidium in pregnant Bulgarian women from an iodine-deficiency endemic region
Authors: Bacelova M. , Gatseva P. , Deneva T. , Davcheva D. , Bivolarska A. 
Published: October 2022

Abstract
Trace elements are essential for the biochemistry of the cell. Their reference values have been found to differ considerably in pregnant women stratified by age, place of residence, anthropometric status, and length of pregnancy. In optimal amounts, these elements reduce the risk of pregnancy complications. Subclinical hypothyroidism in pregnancy is associated with adverse maternal and neonatal outcomes. We aimed at determining the effects of Zn, Cu, Mg, and Rb on pregnant women in an iodine deficiency endemic region and find their relationship with the thyroid status and nutrition. We evaluated the iodine status of 61 healthy pregnant women from an endemic region in Bulgaria. TSH and FT4 levels were measured using ELISA. We found elevated levels of copper that differed the most between the first and second trimesters; Cu and TSH were found to be positively correlated (р<0.05). Lower Cu levels were found in pregnant women consuming pulses more than 2–3 times a week (р=0.033). The women consuming fish more than 2–3 times a week had higher levels of Rb. We found a pronounced iodine deficiency in more than half of the examined women in the first to third trimesters, without any effect of pregnancy on the ioduria (р=0.834). All second and third trimester cases were associated with severe ioduria (< 150 µg/L). The high Cu levels were associated with SCH and less pulse consumption during pregnancy in an iodine deficiency endemic area. SCH was found in 24% of the pregnant women in such an area while in 13% of them SCH had progressed to overt hypothyroidism.
Separation Effect, Pain Perception During Functional Activity and Gingival Inflammation of Elastomeric and Kansal Separators- A Split Mouth Study
Authors: Thejasri Keerthipati , Singaraju Gowri Sankar , Marya Anand , Priyanka J S Yamini , Shaik Shajin , Mandava Prasad 
Published: October 2022

Abstract
Introduction:
An effective space opening for band placement with minimal pain and gingival inflammation is a prime requisite during fixed orthodontic procedures. The study aimed to compare the effectiveness of two types of separators, elastomeric and Kansal, in the amount of space opening, pain perception elicited, and gingival inflammation.
Methods
A random split-mouth study was designed with 30 subjects undergoing Fixed orthodontic treatment. Two different separators(Elastomer and Kansal) were placed alternatively on the left and right sides around the mesial and distal sides of the first molars in the mandibular arch of each subject. After three days, the amount of separation after three days was assessed with a leaf gauge on both mesial and distal sides. The subjective pain perception by Visual analog Scale (VAS) at different points and during different functions for each of the three days was evaluated. A self-filled chart was utilized to be performed by the patients.
Results
The most significant amount of separation(0.28mm) was found with elastomers on the mesial side and is statistically significant (p < 0.001) compared to the mesial side(0.18mm). The Kansal separators produced equivalent separation on mesial (0.19mm) and distal sites(0.17mm). The highest pain score was found after 24 hours with elastomeric separators (median-40) for chewing and biting and the least for sleep(median-30). There is a statistical difference of pain perception between elastomers and Kansal separators at different points for the given function ( p < 0.001).
Conclusion
Both the separators produced adequate separation after a minimum 3 days. Kansal produces minimum discomfort and pain compared to elastomeric separators.