bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knockdown of PRKD2 Enhances Chemotherapy Sensitivity in Cervical
Cancer via the TP53/CDKN1A Pathway
Authors: Hu Zheng , Ma Ji , Gong Danni , Feng Ruijing , Wang Xin , Chen Hongwei , Cao Chen , Liu Ting , Zhao Tong , Chen Huang , Tian Rui , Ni Yangyang , Tian Xun 
Published: August 2022

Background::
Chemotherapy is the common treatment for cervical cancer, and the occurrence
of drug resistance seriously affects the therapeutic effect of cervical cancer. Our previous study
found that PRKD2 mutations occurred only in cervical cancer patients with chemotherapy resistance.
However, the relationship between PRKD2 and drug resistance of cervical cancer remains unknown.

Objective::
We aim to clarify the relationship between PRKD2 and drug resistance of cervical cancer.

Methods::
Samples of patient tumor tissue were collected before chemotherapy and sequenced by
WES. Chemotherapy clinical response was determined by measuring tumor volume. The expression of
PRKD2, cell viability, and apoptosis were assessed by qRT-PCR, Western blot, CCK8, and flow cytometry
in SiHa and ME180 cells after transfected with siPRKD2. The chemotherapy sensitivity signaling-
related proteins were analyzed by Western blot. The expression levels of PRKD2、TP53, and
CDKN1A in tissues were detected by immunohistochemistry staining.

Results::
The expression of PRKD2 was higher in chemotherapy-resistant cervical cancer patients.
PRKD2 knockdown increased the chemotherapy sensitivity of cervical cancer cells via the
TP53/CDKN1A pathway, which led to G1 arrest and cell apoptosis. Furthermore, downregulation of
PRKD2 enhances chemotherapeutic sensitivity in cervical cancer patients through the TP53/CDKN1A
pathway.

Conclusion::
In summary, PRKD2 may be a promising therapeutic target to improve the efficacy of
chemotherapy.
The Learning Contract and its Impact on Scholarship among Moroccan Nursing Students
Authors: Lamiri Abderrahmane , Lhbibani Amina , Qaisar Rabia , Khoaja Driss , Abidi Omar , Khyati Abderrahim , Bouzoubaa Hind 
Published: August 2022

Background:
E-learning refers to the use of new technologies to deliver distance learning programs. This mode of learning is also considered one of the innovative teaching/learning methods best suited to the current conditions, which entail the suspension of face-to-face courses due to the COVID-19 pandemic to ensure continuity of training, overcome learning difficulties and increase student autonomy and motivation. Our study focuses on this teaching model as an example of an apprenticeship contract, often adopted in technical, vocational, work-linked training. The aim of this study is to measure the perception of this learning contract through e-learning and its impact on learning among multi-skilled nursing students in semester four (S4) of the Professional License of the Higher Institute of Nursing and Health Techniques of Casablanca within the framework of the course of nursing care in psychiatry.

Methods:
A group of 58 students participated in a survey conducted by questionnaire, with a response rate of 86.20%.

Results:
The results revealed that the students had a positive perception regarding the use of the learning contract; according to them, the learning contract approach increases autonomy, motivation and the application of the theoretical courses in practice.

Conclusion:
The learning contract offers several advantages as a learning strategy and this has been implemented in different nursing education contexts, which may encourage nursing educators to use this contract more widely in theoretical and also practical teaching.
GENDER ATTITUDE TOWARDS ADOLESCENT’S PREMARITAL SEX IN SENIOR AND JUNIOR HIGH SCHOOLS IN THE NEW JUABEN MUNICIPALITY IN GHANA
Authors: TSOTOVOR LOVEDALE ADZO , DADEY GERTRUDE OTUBEA 
Published: August 2022

The objective of the study was to assess adolescent’s attitudes towards premarital sex in Senior and Junior High Schools in the New Juaben Municipality in Ghana. A descriptive survey design was chosen for the study. The population of the study consisted of five thousand, one hundred forty-one (5,141) in-school adolescents in Junior and Senior High Schools in New Juaben Municipality. Convenient and random sampling techniques were used to select the study area, schools and respondents for the study. A convenient sampling technique was used to select the New Juaben Municipality. A random sampling method was used to select 250 respondents (students) from two Junior High Schools and two Senior High Schools in New Juaben Municipality. The main instrument used for data collection was a questionnaire. The data collected were statistically analysed using Statistical Package for the Social Sciences (SPSS). Both and descriptive statistics and the Analysis of Variance (ANOVA) test were used in the data analysis. Descriptive statistics such as frequency distribution in tabular form in graphical forms, and measures of central tendencies were used to analyse the data. The study concluded that the positive sexual behaviours of adolescents in Junior and Senior High Schools are evident in their attitude towards premarital sex. Adolescents in Senior High and Junior High Schools in the New Juaben Municipality exhibit a positive attitude towards premarital sex as the majority of them do not see that abstaining from sex would make them sick or look odd in society, neither would it give them problems during intercourse when they finally marry.
Hydraulic and thermal stability of independent systems of apartment heating
Authors: Toropov Alexey L. 
Published: August 2022

Introduction. Individual apartment heating has been used in the Russian Federation since 1998. More than two million wall-mounted gas boilers were installed in the apartments of apartment buildings, 99 percent of which are wall-mounted double-circuit convection boilers with atmospheric burners. Their hydraulic and thermal stability is a requirement of the current standards for the design of heating systems. The heat generator of independent heating systems is part of a single circulation circuit; it has its own hydraulic resistance. The circulation of coolant and transfer of thermal energy through the pipelines to heating appliances is performed by the circulation pump. Stability of an independent heating system, in contrast to the centralized one, depends on the regulatory parameters of energy supply (pressure, calorific value of gas, voltage of the electric network).
Materials and methods. The authors studied the thermal capacity parameters of the gas burner and the circulation pump within the framework of current standards of variable supply of energy resources and their influence on the hydraulic and thermal stability of systems.
Results. Quantitative results of the studied parameters were obtained. The authors identified the coefficient of heat power generation depending on gas pressure, range of pressure change and flow characteristics of circulation pumps, wall boiler hydraulic resistance, influence of thermostatic valves of heating appliances and the use of antifreezes.
Conclusion. An independent heating system differs from a centralized one in that a heat generator and a circulation pump are its integral parts. The operating parameters of independent heating systems depend on standard parameters of energy resources supply. Hydraulic resistance does not determine thermal stability. When calculating the hydraulic resistance of the heating circuit, it is necessary to take into account the hydraulic resistance of the gas boiler. Thermal heads on heating appliances and antifreezes in the system of independent apartment heating contradict the concept of hydraulic stability of the heating circuit. Thermal stability of an apartment heating system should be checked taking into account the algorithms of the heat generator performance.
Political Stability, Board Tenure, and Corporate Cash Holding
Authors: Ariff Akmalia M. , Jaafar Aziz , Kamarudin Khairul Anuar 
Published: August 2022

ABSTRACT
This paper investigates whether board tenure is associated with corporate cash holding and whether country-level political stability moderates the effect of board tenure on corporate cash holding. Using 16,351 firm-year observations across 39 countries, our main results show that firms with higher average board tenure exhibit lower cash holding. Furthermore, strong political stability mitigates the negative relationship between the average board tenure and corporate cash holdings. Our results are robust to various specifications, including endogeneity issue, weighted least-square regression, global financial crisis effect, and alternative measures for corporate cash holding and country-level institutional factors. Overall, our results imply the need to strengthen the institutional environment, given that countries with stable politics are those with incentives for the board to function effectively.
JEL Classifications: G38; G18; M41; M43; M44.
Influence of ibuprofen combined with corticotomy on tooth movement and alveolar bone remodeling in rats
Authors: Jindarojanakul Chanakant , Samruajbenjakun Bancha 
Published: August 2022

ABSTRACT

Objectives
To investigate the effects of corticotomy-assisted orthodontic tooth movement and administration of ibuprofen on tooth movement rate and alveolar bone response.

Materials and Methods
A total of 78 adult male Wistar rats were randomly assigned to five groups: one baseline group (no treatment) and four experimental groups including orthodontic tooth movement only (OTM), orthodontic tooth movement with ibuprofen (OTMI), corticotomy-assisted orthodontic tooth movement (COTM), and corticotomy-assisted orthodontic tooth movement with ibuprofen (COTMI). Corticotomy was performed on a maxillary molar unilaterally. Nickel-titanium closed-coil springs generated a 10-gram force for maxillary first molar movement. The experimental drug groups received 15 mg/kg of ibuprofen, and the other groups received reverse osmosis water. Tooth movement and bone volume fraction were evaluated by micro–computed tomography on days 0, 7, 14, and 21.

Results
The corticotomy groups had statistically significantly higher tooth movement and lower bone volume fraction than the orthodontic groups (P &lt; .05). The amount and rate of tooth movement were statistically significantly different between the OTM and OTMI groups, but not statistically significantly different in bone volume fraction. However, statistically significant differences were not observed in any measurements between the COTM and COTMI groups.

Conclusions
Ibuprofen during orthodontic tooth movement inhibited tooth movement and alveolar bone remodeling but had no effect on corticotomy-assisted orthodontic treatment.
Economic Restructuring in the Context of Industrial Revolution 4.0 in Thai Nguyen Province, Vietnam
Authors: Ha Nguyen Thi Thu , Huyen Ta Thi Thanh , Van Pham Thi Ngoc 
Published: August 2022

Towards a digital economy in the context of the industrial revolution 4.0, economic restructuring is essential. The article focuses on studying the status of the economic structure of Thai Nguyen province in many aspects such as the contribution of economic sectors, economic activities, investment capital structure, and labor structures in economic sectors. The study has shown an overview of the province's economy, and pointed out the limitations, thereby proposing several synchronous and feasible solutions to accelerate the restructuring of the province's economy in the context of industrial revolution 4.0.
Control and Path Planning of Mobile Swarm Robots Using Blockchain Technology with Particle Swarm Optimization
Authors: Adeoti Temidayo Samuel , Olasoji Yekeen Olajide 
Published: August 2022

Technological advancement has made robots become rampant in industrial automation and globalization, as it’s fast and efficient in delivering tasks in industries with no supervision. This work shows the use of blockchain technology (smart contract) in controlling a swarm of robots combined with particle swarm optimization for solving the navigation path. The technique in this research modeled a new fitness function, that uses the optimal path generation and barrier avoidance for the mobile robot’s movement within the swarm, while the blockchain smart contract was integrated to control the robot’s speed. Simulated results validate path optimization and speed control with PSO and BT.
Estimating Hydraulic Conductivity, Transmissibility and Specific Yield of Aquifer in Barind Area, Bangladesh Using Pumping Test
Authors: Ali Md. Hossain , Zaman Md. Hasan , Biswas Partha , Islam Md. Aktarul , Karim Nazmun Nahar 
Published: August 2022

Reliable hydraulic parameters values are essential and crucial basic data for potential groundwater withdrawal (aquifer yield) and also for sustainable groundwater management. They are also essential for simulation model study for different management scenario analyses. The laboratory test has limitations, while in situ tests produce representative aquifer parameters. The pumping test method is the only method that provides simultaneous information on the hydraulic behavior of the well, the aquifer, and the aquifer boundaries. Pumping tests were performed to determine aquifer hydraulic properties such as hydraulic conductivity (K), transmissibility (T), and specific yield (Sy) at two Upazilas of the Barind area, namely Nachol and Niamatpur. The aquifer formation is composed of layers: upper fine sand, medium sand, a conductive sand layer, and lower fine sand at the bottom, below which the impervious clay layer exists. The K was determined through Dupit’s steady radial flow equation, T through Theis’s and Copper-Jacob approach, and Sy through Copper-Jacob and gravity drainage of aquifer materials. The mean K, T, and Sy were found as 30.3 m3/m2/day, 756.7 m3/m/day, and 4.6%, respectively for the Nachol location; and 52.7 m3/m2/day, 1027.3 m3/m/day and 6.6%, respectively for Niamatpur location. The values obtained are supported by regional values reported earlier, and also by other locations’ values situated elsewhere having similar aquifer materials. To achieve long-term sustainability in the studied locations, withdrawal of groundwater resources should be optimized considering the aquifer hydraulic properties values.
Precision Grounding Combined with Precision Deep Tissue Massage
Authors: Khalid Madiha , Madvin Jeremy 
Published: August 2022

Massage is a popular complementary and alternative medicine (CAM) treatment. In recent years, deep tissue massage (DTM) has grown in popularity. As a result, DTM with grounding should be examined as any other treatment method to determine its safety and efficacy. Massage can help to reduce inflammation, speed up recovery, and relieve muscle pain. We study beneficial mechanisms in this paper by combining the idea of grounding with the massage. Grounding massage has been shown to help stabilize the physiology of the body, inflammation, reduce pain, enhance sleep, as well as stress, increase stamina and blood flow, and improve health by reconnecting the body with the electrostatic forces of the Earth. By modulating inflammatory signaling pathways, this mechanism can reduce collateral sprouting, secondary injury, and nerve sensitization, leading to better damage recovery and pain avoidance. On the other hand, deep tissue massage has long been used as a key therapeutic therapy in Traditional Medicine because of its low side effects and therapeutic efficacy. This paper examines the possibility of deep tissue massage with earthing as a simple and widely available technique with significant clinical value.
Prognostic value of right ventricle to pulmonary artery coupling in transcatheter aortic valve implantation recipients
Authors: Adamo Marianna , Maccagni Gloria , Fiorina Claudia , Giannini Cristina , Angelillis Marco , Costa Giulia , Trani Carlo , Burzotta Francesco , Bruschi Giuseppe , Merlanti Bruno , Poli Arnaldo , Ferrara Erica , Fineschi Massimo , Iadanza Alessandro , Chizzola Giuliano , Metra Marco 
Published: August 2022

Aims
To investigate the impact of the right ventricle to pulmonary artery (RV-PA) coupling on the outcome of patients undergoing transcatheter aortic valve intervention (TAVI), and to describe changes in right ventricular function, pulmonary hypertension, and their ratio after TAVI.

Methods
Three hundred and seventy-seven patients from the Italian ClinicalService Project, who underwent TAVI between February 2011 and August 2020, were included. Tricuspid annular plane systolic excursion/pulmonary artery systolic pressure (TAPSE/PASP) ratio was retrospectively calculated as a surrogate of RV-PA coupling. The population was stratified according to TAPSE/PASP using a cut-off of 0.36 mm/mmHg derived from a receiving operating characteristic (ROC) curve. The primary end point was 6-month all-cause death.

Results
Compared with patients with a TAPSE/PASP ratio ≥0.36 mm/mmHg (81%), those with TAPSE/PASP ratio <0.36 mm/mmHg (19%) had more comorbidities and were more symptomatic.
Moreover, they were more likely to receive general anesthesia and an old generation device. Device success was similar between the two groups. A TAPSE/PASP ratio <0.36 mm/mmHg was associated with a higher risk of all-cause death at 6-months (17.3% versus 5.3%; adjusted HR 2.66; P = 0.041). The prognostic impact of the TAPSE/PASP ratio was stronger than the impact of TAPSE and PASP as separate parameters and was independent of the surgical risk score. Both TAPSE, PASP, and their ratio improved from baseline to 1 month and 6 months after TAVI.

Conclusions
A TAPSE/PASP ratio <0.36 mm/mmHg is strongly associated with an increased risk of mortality after TAVI. Providing a left ventricle unloading, TAVI is associated with improvement of both TAPSE, PASP, and their ratio.
The Psychological Memory Forgetting Model Based on the Analysis of Linear Differential Equations
Authors: Yang Yangang 
Published: August 2022

Abstract
The article uses mathematical theory to derive a quasi-linear differential equation describing the law of memory forgetting in psychology. The nonlinear automatic control machine model is used to preliminary model the indiscriminate memory problem in psychology. The research obtains the recommended evaluation value with the forgetting characteristics in memory psychology. The experimental results found that the model reasonably solves the problem of quantification of timeliness.
Effective Outcome of HBOT as an Adjuvant Therapy in Patients Diagnosed with COVID-19 in a Tertiary Care Hospital – A Preliminary Study
Authors: Palaniappan Thiruppathy , Shaikh Asif , Kirthika Navamani 
Published: August 2022

Abstract

Introduction
Hyperbaricoxygen therapy (HBOT) is breathing100% oxygen in pressurised chamber. This therapy ensures quick oxygen delivery to the bloodstream. In patients with severe COVID-19 pneumonia, progressive hypoxemia occurs. Oxygen therapy hasa significant role in its management.

Aim of the study
The objective was to study the efficacy of hyperbaric oxygen therapy (HBOT) as adjuvant therapy for reducing the requirement of additional oxygen supplementationin patients with moderate to severe ARDS diagnosed with COVID-19.

Methods
A single-centre prospective pilot cohort study was conducted ata tertiary care hospital from December 2020 to February 2021 over two months. Fifty patients with COVID-19 needingoxygen, satisfying the selection criteria, were included. Hyperbaricoxygen therapy wasgiven to all patients. The patient received30-45 minutes of hyperbaric oxygen with 15 minutes of pressurizing and depressurizing at 2.0 atmosphere absolute (ATA) with or without airbrakesas per the critical care team. Oxygen requirement, PaO2, andcondition at discharge were considered as primary outcome variables.

Results
Among the 50 participants studied, the mean age was 53.64±13.26 years. Out of 50 participants, 49(98.00%) had PaO2≤80 mmHg, and one (2.00%) had >80 PaO2. All the participants 50(100%) had PaO2 as 90 mmHg after three sittings.

Conclusion
This studyshows promising results in using HBOT to overcome respiratory failure in COVID-19. HBOT reduced the need for oxygen by improving the oxygen saturation levels.
Predictive Value of Systemic Immune-inflammation Index in Determining Mortality in COVID-19 Patients
Authors: Karaaslan Tahsin , Karaaslan Esra 
Published: August 2022

Abstract

Aim
The aim of this study was to evaluate whether systemic immune-inflammation index (SII) could predict mortality in patients with novel coronavirus 2019 (COVID-19) disease.

Methods
This two-center, retrospective study included a total of 191 patients with confirmed diagnosis of COVID-19 via nucleic acid test (NAT). The SII was calculated based on the complete blood parameters (neutrophil × platelet/lymphocyte) during hospitalization. The relationship between the SII and other inflammatory markers and mortality was investigated.

Results
The mortality rate was 18.3%. The mean age was 54.32±17.95 years. The most common symptoms were fever (70.7%) and dry cough (61.3%), while 8 patients (4.2%) were asymptomatic. The most common comorbidities were hypertension (37.7%), diabetes (23.0%), chronic renal failure (14.7%), and heart failure (7.9%) which all significantly increased the mortality rate (p<0.001). There was a highly positive correlation between the SII and polymorphonuclear leukocyte (PNL), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) (r=0.754, p<0.001; r=0.812, p<0.001; r=0.841, p<0.001, respectively), while a moderate, positive correlation was found between the SII and C-reactive protein (CRP) (r=0.439, p<0.001). There was a significant correlation between the SII and mortality (U=1,357, p<0.001). The cut-off value of SII was 618.8 (area under the curve=0.751, p<0.001) with 80.0% sensitivity and 61.5% specificity. A cut-off value of >618.8 was associated with a 4.68-fold higher mortality.

Conclusion
Similar to NLR and PLR, the SII is a proinflammatory marker of systemic inflammation and can be effectively used in independent predicting COVID-19 mortality.
Right Heart Failure as an Atypical Presentation of Chronic Type A Aortic Dissection - Multimodality Imaging for Accurate Diagnosis and Treatment. A case report and mini-review of literature
Authors: Tilea Ioan , Dumbrava Robert Adrian , Ratiu Alexandra Mihaela , Harpa Marius Mihai , Banceu Cosmin Marian , Petra Dorina Nastasia , Suciu Horatiu 
Published: August 2022

Abstract

Background
An intrapericardial organized haematoma secondary to chronic type A aortic dissection is an extremely rare cause of right heart failure. Imaging studies are essential in recognising and diagnosis of this distinctive medical condition and guiding the anticipated treatment.

Case presentation
A 70-year-old male patient was admitted for progressive symptoms of right heart failure. His cardiovascular history exposed an aortic valve replacement 22 years before with a Medtronic Hall 23 tilting valve with no regular follow-up. Classical signs of congestion were recognized at physical examination. Transthoracic two-dimensional echocardiography and thoraco-abdominal computed tomography angiography, as essential parts of multimodality imaging algorithm, established the underlying cause of right heart failure. Under total cardiopulmonary bypass and cardiac arrest, surgical removal of the haematoma and proximal repair of the ascending aorta with a patient-matched vascular graft were successfully performed. The patient was discharged in good condition with appropriate pharmacological treatment, guideline-directed; no imagistic signs of acute post-surgery complications were ascertained.

Conclusion
This paper highlights the importance of recognizing and providing a timely clinical and imagistic diagnosis of this very rare, potentially avoidable cause of right heart failure in patients with previous cardiac surgery.