bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of hepatocellular carcinoma after sustained virologic response in hepatitis C virus patients without advanced liver fibrosis
Authors: Tahata Yuki , Sakamori Ryotaro , Yamada Ryoko , Kodama Takahiro , Hikita Hayato , Nozaki Yasutoshi , Oshita Masahide , Hiramatsu Naoki , Miyazaki Masanori , Mita Eiji , Yamamoto Keiji , Ohkawa Kazuyoshi , Kaneko Akira , Ito Toshifumi , Doi Yoshinori , Yakushijin Takayuki , Hijioka Taizo , Fukui Hiroyuki , Imanaka Kazuho , Yoshida Yuichi , Yamada Yukinori , Tatsumi Tomohide , Takehara Tetsuo 
Published: June 2022

AbstractAimHepatocellular carcinoma (HCC) after sustained virologic response (SVR) has been observed even in hepatitis C virus (HCV) patients without advanced liver fibrosis. Identifying predictors for HCC incidence in patients without advanced liver fibrosis will enable efficient post‐SVR HCC surveillance. This study aimed to develop a scoring system to predict the incidence of HCC after SVR in HCV patients without advanced liver fibrosis.MethodsA total of 1682 HCV patients without advanced liver fibrosis (defined as Fibrosis‐4 index <3.25) with no history of HCC who initiated direct‐acting antiviral treatment between September 2014 and October 2020 at 26 institutions, and achieved SVR24, were included. We divided 1682 patients into training (1122) and validation (560) cohorts.ResultsIn the multivariate analysis, baseline age ≥ 65 years (p = 0.030), alanine aminotransferase (ALT) levels at SVR24 ≥ 30 U/l (p = 0.001), and α‐fetoprotein (AFP) levels at SVR24 ≥ 5.0 ng/ml (p = 0.001) were independent predictors for HCC incidence in the training cohort. We developed a scoring system to predict HCC incidence after SVR24 using these three factors (1 point was added for each factor). The cumulative HCC incidence rates at 5 years were 7.1% in patients who scored 2 or 3, and no patients developed HCC in those who scored 0 in the validation cohort.ConclusionsOur scoring system using the three factors of baseline age, ALT levels at SVR, and AFP levels at SVR is useful for post‐SVR HCC surveillance of patients without advanced liver fibrosis.
The role of social factors in the acquisition of vernacular English: A variationist study with pedagogical implications
Authors: Davydova Julia 
Published: June 2022

AbstractThe study reported here explores the role of various social factors in the L2 acquisition of vernacular variation. In so doing, it investigates acquisition of probabilistic constraints on the use of a globally available innovation, quotative be like, as a diagnostic linguistic variable. Drawing on data obtained from 37 individuals from three age cohorts all living in Mannheim, Germany, and applying the variationist method of evaluation, I show that German learners managed to acquire the variable grammar of quotative be like. I also test for a diverse set of sociolinguistic and sociopsychological variables by way of exploring their relative contribution to the process of acquiring structured variation by adult learners. The results of mixed‐effects modeling (Johnson 2009) show that acquisition of quotative be like is mediated by age, gender, and learners’ linguistic identity. I conclude that EFL (English as a Foreign Language) learners’ (implicit) knowledge about structured variation is an inherent component of their sociolinguistic competence, while drawing English teachers’ attention to the general importance of the issue concerning learners’ knowledge about structured variability.
Gender inequities in medical research funding is driving an exodus of women from Australian STEMM academia
Authors: Borger Jessica G , Purton Louise E 
Published: June 2022

AbstractUniversally, women are under‐represented in senior academic leadership in science, technology, engineering, maths and medicine (STEMM). Successful funding outcomes are a critical point in career progression, to continue both a scientist’s research but also for their retention within the STEMM workforce. A common explanation for the lower success rate of women in securing funding is that fewer women apply for funding. However, this does not adequately explain the gender inequities in funding outcomes, both in terms of fewer funded applications and also of reduced funding awarded per grant, resulting in less overall success. Gendered funding outcomes occur within academic institutions and peak funding bodies due to historical, systemic conscious and unconscious biases during peer review. As a cumulative bias over a woman’s research career, this results in women being under‐represented in STEMM and the loss of their contributions to medical research, reducing innovation through a lack of diverse workforces.
Transgender people in the nursing discourse: An integrative review
Authors: Padilha Maria Itayra , Caravaca‐Morera Jaime Alonso , Gentil Ana Gabriela Bastos , Dal Vesco Stéfany Nayara Petry , Bellaguarda Maria Lígia dos Reis , Silva Amina 
Published: June 2022

AbstractObjectiveTo integrate and analyse the literature produced by nurses in terms of care, education and understanding of the reality of transgender (trans) people.DesignAn integrative review methodology guided by the framework proposed by Whittemore and Knafl.Data sourcesThe search strategy was applied in the following databases: Medline, Embase, Scopus, Web of Science and CINAHL, as well as in Biblioteca Virtual de Saúde, during February and March 2021, with no time frame.Review methodsThe references found were assessed according to the eligibility criteria established. The information of the articles included was extracted, and a thematic analysis was performed to synthesize the review findings.ResultsThe searches in the databases yielded 2859 articles; 985 after removing duplicates, and 33 articles were included in this review. Three major themes were identified: (1) Understanding the trans universe through the trans perspective; (2) Understanding health and nursing care for trans people; and (3) Trans women as the focus of health and nursing care. The themes evidenced in the lens of nurses and clients the importance of nursing training at all levels to prepare professionals on how to provide culturally competent nursing care for this population and reduce healthcare inequities.ConclusionNurses must work to provide a space for convergence and enhancement of the rights of trans people and cease to be a verticalized care model. To such end, it is necessary to devise places and possibilities to teach and learn, to construct and reconstruct a culturally competent nursing care.ImpactThis review highlighted the current knowledge and identified gaps in the understanding of nurses, health professionals and students about the experience lived by trans people, resulting from the lack of training and continuing education of these professionals.
Mechanistic vs. empirical ablation of atria during repeat ablation for atrial arrhythmias despite effective pulmonary vein isolation
Authors: Canpolat Ugur 
Published: June 2022

AbstractThe management of atrial arrhythmia recurrence during repeat catheter ablation procedure is unclear despite persistent pulmonary vein isolation. It should be clarified whether an induced non‐PV trigger‐based (mechanistic) ablation approach more focusing on low‐voltage zones is more effective compared to an empirical ablation of low‐voltage zones via linear lesions during repeat ablation procedures. The operators should catch all triggers if possible rather than messing with the substrate.
High waist circumference is a risk factor for hypertension in normal‐weight or overweight individuals with normal metabolic profiles
Authors: Cheng Chen , Sun Jin‐Yu , Zhou Ying , Xie Qi‐Yang , Wang Li‐Yuan , Kong Xiang‐Qing , Sun Wei 
Published: June 2022

AbstractThis study aims to investigate the relationship between waist circumference and hypertension risk in normal‐weight/overweight individuals with normal cardiometabolic profiles. The authors included 7217 normal‐weight and overweight individuals with normal cardiometabolic profiles from the 2001 to 2014 US National Health and Nutrition Examination Survey. The authors summarized demographic characteristics, cardiometabolic profiles, and behavioral factors across waist circumference quartiles. Then, in the logistic regression analysis, the authors observed a positive and significant association between waist circumference (as a continuous variable) and the prevalence of hypertension in all three models (nonadjusted, minimally adjusted, and fully adjusted), with odds ratios (95% confidence intervals) of 1.76 (1.65–1.86), 1.29 (1.20–1.39), and 1.24 (1.09–1.40), respectively. When analyzed as a categorical variable, individuals in the highest waist circumference group had a 1.48‐fold increased risk of hypertension than the lowest group in the fully adjusted model. Moreover, the Cox regression analysis revealed a positive and significant association between waist circumference and all‐cause mortality in individuals with hypertension in the nonadjusted model (HR, 1.27; 95% CI, 1.10–1.47) and the fully adjusted model (HR, 1.59; 95% CI, 1.22–2.06). In conclusions, our results showed that, even in those with normal metabolic profiles, high waist circumference was significantly associated with the increased prevalence of hypertension. And once hypertension has been established, patients with high waist circumference showed elevated all‐cause mortality. Therefore, waist circumference should be routinely measured and controlled regardless of metabolic profiles.
Anticancer treatments and photosensitivity
Authors: Sibaud V. 
Published: June 2022

AbstractDrug‐induced photosensitivity is associated with a wide range of anticancer treatments, including conventional chemotherapeutic agents, targeted anticancer therapies, and immune checkpoint inhibitors. These dermatologic adverse events can have a major impact on the well‐being and quality of life of cancer patients, leading to dose modifications and interruption or discontinuation of anticancer treatments in severe cases. However, the heterogeneous nature of the photosensitive reactions induced by these agents, as well as the common concomitant use of other potentially photosensitizing drugs (antibiotics, voriconazole, nonsteroidal anti‐inflammatory drugs, etc.), can make the diagnosis and, therefore the prevention, of these adverse events particularly challenging. The aim of this review is to describe the most characteristic forms of photosensitivity observed in patients being treated with anticancer treatments, including phototoxicity and photoallergy, and other potentially photo‐induced manifestations such as UV recall, exaggerated sunburn reactions associated with treatment‐related vitiligo, drug‐induced cutaneous lupus erythematosus, and UV‐induced hyperpigmentation. We also discuss the photosensitive reactions recently reported with new‐generation targeted anticancer therapies and immune checkpoint inhibitors and highlight the importance of continued surveillance to identify photosensitizing agents, and of educating patients on the need for preventive UVA/UVB photoprotective measures.
“I've got to break the cycle for my son, so he doesn't go to juvie like his pops”: Interrupting intergenerational patterns of incarceration
Authors: VanderPyl Taryn , Hernandez Katelyn , Melchor‐Ayala Omar 
Published: June 2022

AbstractPatterns of incarceration transmit generationally causing damage to families and communities across decades. Literature is replete with studies on the harmful impact of parental incarceration but is missing the voice of those living within this cycle. This study highlights the perspectives and lived experiences of those who have parents who have been incarcerated, are currently incarcerated themselves,andhave children of their own. This middle generation sheds light on how and why they followed in their parents' footsteps and their desire to break this pattern for their own children. Implications and recommendations are discussed.
Establishment and characterization of a spinal cord tissue cell line from mandarin fish, Siniperca chuatsi and its susceptibility to several viruses
Authors: Gong Jinpeng , Pan Xiaoyi , Lin Lingyun , Zhu Yue , Yao Jiayun , Wang Congxu , Yin Wenlin , Huang Lei , Liu Yihan , Chen Fan , Shen Jinyu 
Published: June 2022

AbstractIn this study, we established and characterized a continuous cell line from the spinal cord tissue of mandarin fish, Siniperca chuatsi and assessed its susceptibility to infectious spleen and kidney necrosis virus (ISKNV), Siniperca chuatsi ranavirus (SCRaV) and Siniperca chuatsi rhabdovirus (SCRV). The cell line, named SCC, has been successively cultured up to 40 passages. The optimal growing conditions of SCC cells were in Leibovitz's L‐15 medium supplemented with 20% foetal bovine serum (FBS) at 28°C. Karyotype analysis demonstrated 48 normal diploid chromosomes in the cells. The identity of S. chuatsi origin of SCC cells was confirmed by partial sequencing of the 16S rRNA and cytochrome oxidase I (COI) genes. Infection susceptibility assessment showed that ISKNV, SCRIV and SCRV and can be stably produced and transmitted in SCC cells, and the replication efficiency of ISKNV, SCRaV and SCRV ranged from 107.4 to 109.6 TCID50/ml. In addition, transmission electron microscopy analysis of ISKNV, SCRAV and SCRV infected SCC cells showed numerous viral particles. In conclusion, the newly established SCC cells provide an important tool for isolation and production of viruses, as well as for molecular and cell biology studies.
Transcriptome analysis and co‐expression network reveal the mechanism linking mitochondrial function to immune regulation in red crucian carp (Carassius auratus red var) after Aeromonas hydrophila challenge
Authors: Xiong Ning‐Xia , Kuang Xu‐Ying , Fang Zi‐Xuan , Ou Jie , Li Shi‐Yun , Zhao Jia‐Hui , Huang Jin‐Fang , Li Ke‐Xin , Wang Rou , Fan Lan‐Fen , Luo Sheng‐Wei , Liu Shao‐Jun 
Published: June 2022

AbstractAeromonas hydrophila is a common pathogen of freshwater fish. In this study, A. hydrophila infection was shown to cause tissue damage, trigger physiological changes as well as alter the expression profiles of immune‐ and metabolic‐related genes in immune tissues of red crucian carp (RCC). Transcriptome analysis revealed that acute A. hydrophila infection exerted a profound effect on mitochondrial oxidative phosphorylation linking metabolic regulation to immune response. In addition, we further identified cellular senescence, apoptosis, necrosis and mitogen‐activated protein kinase signal pathways as crucial signal pathways in the kidney of RCC subjected to A. hydrophila infection. These findings may have important implications for understanding modulation of immunometabolic response to bacterial infection.
Evaluation of the tolerability of monoclonal antibody therapy for pregnant patients with COVID‐19
Authors: Magawa Shoichi , Nii Masafumi , Maki Shintaro , Enomoto Naosuke , Takakura Sho , Maegawa Yuka , Osato Kazuhiro , Tanaka Hiroaki , Kondo Eiji , Ikeda Tomoaki 
Published: June 2022

AbstractAimTo evaluate the tolerability of casirivimab and imdevimab (CAS/IMB) therapy in pregnant women with COVID‐19 in Japan and its impact on the neonate and process of delivery.MethodsEight cases of pregnancy complicated by COVID‐19 and requiring hospitalization during the delta variant epidemic were included. Gestational age, initial symptoms, pregnancy complications and outcome, severity of illness, blood test findings at the time of treatment initiation and on days 3–5 after administration, body temperature at administration, and 8, 24, and 48 h post‐administration, delivery outcome, and neonatal findings were recorded. Ten pregnant women who required hospitalization at the same time and did not receive CAS/IMB were used as controls.ResultsOf the eight cases, seven were mild, and one case was of moderate severity. Body temperature in the CAS/IMB group was significantly higher at 8 h post‐administration than that at the time of administration. However, body temperature significantly reduced at 24 and 48 h post‐administration in the CAS/IMB group compared with that in the control group. There were no apparent adverse events after CAS/IMB administration.ConclusionsMaternal administration of CAS/IMB was safe. Although it was difficult to evaluate the improvement in disease by blood test findings, the fever improved within 24 h, which suggests rapid improvement in patient condition.
The impact of COVID‐19 lockdown on children with recurrent wheezing and asthma in Spain
Authors: Daoud Pérez Zarife , Rázquin Arias Marcelo , López‐Escobar Alejandro , Díaz‐Conradi Alvaro , Arce Amalia , Ruggeri Nora , Romero Blanco Isabel , Díaz‐Delgado Blanca , Ventura Wichner Paula S 
Published: June 2022

AimThe rapid spread of a novel human coronavirus SARS‐CoV‐2 led to drastic measures world‐wide. Most countries were forced to declare a national lockdown. We studied the effect of lockdown measures on the level of asthma control and maintenance treatment in children with recurrent wheezing and asthma during the first wave of COVID‐19 in Spain.MethodsWe analysed children with recurrent wheezing or asthma before and after the implementation of the lockdown, by using a questionnaire aimed to examine pre‐existing respiratory disorders, step treatment and level of asthma control before/after lockdown, COVID history and laboratory testing including IgG SARS‐CoV‐2.ResultsWe enrolled 475 asthmatic and pre‐school wheezers (60.6% males), mean age 5.6 years. There were no differences in asthma treatment comparing both periods: 81.7% maintained the same treatment (P = 0.103). According to child asthma‐control questionnaire, 87.7% remained well controlled during confinement. Nearly, a third of children (34.9%) needed reliever treatment, mainly in older children. Determination of IgG SARS‐CoV‐2 was performed in 233 children (49.1%) of whom 17 (7.3%) tested positive. Seven patients positive to IgG SARS‐CoV‐2 were assisted in the emergency department and two required hospital admission.ConclusionsDuring COVID‐19 lockdown in Spain, most children with recurrent wheezing and asthma remained well controlled from their underlying disease and did not modify greatly their maintenance treatments. Unexpectedly, we also observed that those children who tested positive to SARS‐CoV‐2 IgG showed a significant increase in paediatric hospital admissions and attendances to urgent care settings.
Phylogenetic and morphological characteristics of Uromycladium falcatariae, the fungal pathogen that causes gall rust epidemics of Falcataria moluccana in Indonesia
Authors: Lelana Neo Endra , Wiyono Suryo , Giyanto  , Siregar Iskandar Z. , Anggraeni Illa 
Published: June 2022

AbstractCurrently, gall rust is the most important disease of Falcataria moluccana in Indonesia. The gall rust pathogen was identified as Uromycladium falcatariae, in a recent study using molecular approaches. However, the molecular study of the F. moluccana gall rust pathogen from Indonesia has not been reported. Therefore, the study aimed to analyse this through molecular phylogenetic of the internal transcribed spacer‐5.8S rDNA (ITS), the cytochrome oxidase 3 (CO3) gene and the gene encoding the large ribosomal subunit (LSU) as well as analyses of its spore dimensions and number of striae. For this purpose, isolates of the gall rust pathogen of F. moluccana were collected from three provinces in Java and one province in Sumatra. The average of spore lengths and the widths varies, with the isolate from Bengkulu, having the largest spore dimension. For the number of striae, isolate from Central Java had a wider range compared with other isolates. Phylogenetic analysis of ITS, LSU and CO3 sequences using maximum likelihood revealed a genetically distinct group of the gall rust pathogen of F. moluccana originating from the various provinces in Indonesia with isolates from the Philippines and Timor Leste. The gall rust pathogens may have evolved to adapt to a populations of F. moluccana in Java.
Population Aging, Demographic Metabolism, and the Rising Tide of Late Middle Age to Older Adult Loneliness Around the World
Authors: Newmyer Lauren , Verdery Ashton M. , Wang Haowei , Margolis Rachel 
Published: June 2022

AbstractThis study examines how population aging shapes a crucial aspect of mental health and social well‐being: loneliness. Drawing on theories of demographic metabolism, United Nations population estimates and projections, and survey data covering approximately 50 percent of the world's population aged 50 and above living in 27 countries, we estimate the role of population aging in shaping cross‐national differences in loneliness from 1990 to 2050. We used survey data to estimate the prevalence of late middle age and older adult loneliness by age and sex and then applied these rates to the evolving age and sex distributions of the populations. Our results highlight massive increases in loneliness at ages 50 and above with a tripling of the number of lonely adults in these age groups in our sample countries from 104.9 million in 1990 to 333.5 million in 2050, increasing variability across countries in the share of their populations composed of lonely adults 50 and above, and the feminization of global later life loneliness with an increasing share of lonely adults in these age ranges being women. These results illustrate the power of demographic modeling to advance our understanding of national profiles of mental health and social well‐being.
Self‐ but not other‐mentalizing moderates the association between BPD symptoms and somatic complaints in community‐dwelling adolescents
Authors: Ballespí Sergi , Nonweiler Jacqueline , Sharp Carla , Vives Jaume , Barrantes‐Vidal Neus 
Published: June 2022

AbstractObjectivesThe aim of this study was to evaluate the potential moderator role of poor mentalization in the association between borderline personality disorder (BPD) traits and somatization, specifically focusing on the polarities of self‐ and other‐mentalizing.DesignThis is a cross‐sectional, general population study evaluating adolescents (n = 162, 61.3% female; ages 12–18, M = 14.63, SD = 1.02). The relationship between BPD traits and somatization was evaluated with self‐mentalization (attention to emotions and clarity of emotions) and other‐mentalizing as moderator variables.MethodsOne hundred sixty‐two adolescents without serious mental health disorders were evaluated using self‐report measures for borderline personality disorder traits (screening questionnaire for the Structured Clinical Interview for DSM‐IV Personality Disorders (SCID‐II), somatic symptoms using the Somatic Symptoms Questionnaire (SSQ), self‐mentalizing using the Trait Meta‐Mood Scale‐24 (TMMS) and other‐mentalizing using the Adolescent Mentalizing Interview (AMI)). Linear regressions were conducted to test the moderation effects of self‐ and other‐mentalizing in the relationship between BPD symptoms and somatic complaints, controlling for age and sex. Moderation analysis was conducted using PROCESS version 3.5.ResultsThe association between BPD symptoms and somatic complaints was moderated by a self‐mentalizing dimension (emotional clarity) (b = −0.019, 95% CI = −0.0379 to −0.0002, p = .0476), but not other‐mentalizing (b = 0.027, 95% CI = 0.000 to 0.053, p = .051). The effect of BPD symptoms on somatization disappears when emotional clarity is high, regardless the level of attention to emotions.ConclusionsSelf‐mentalizing appears to be an adaptive skill as it attenuates the relationship between BPD traits and somatization. Specifically, emotional clarity rather than simple attention to emotions is the aspect of self‐mentalizing attenuating this association. These results support that self‐mentalization is an important function in the management of body‐associated emotions even in non‐clinical levels of BPD traits. Findings suggest that strengthening self‐mentalizing skills across development might contribute to resilience and salutogenesis.