bluuebunny/crossref_metadata_2025_split huggingface dataset:
Power consumption in a moving baffle oscillatory baffled reactor: A CFD study
Authors: Mortazavi Hamid , Pakzad Leila 
Published: September 2022

AbstractOscillatory baffled reactors (OBRs) can perform high‐intensity mixing under low power consumption, and thus are viable replacements for stirred tank reactors in biological, chemical, and polymer processes. This study simulated the flow inside a moving baffle OBR with single orifice baffles using computational fluid dynamics (CFD). The effect of operational and geometrical parameters along with the fluid density and viscosity on average power consumption and maximum power consumption was investigated, and appropriate correlations for both average and maximum power consumption were obtained. It was found that average and maximum power consumption are independent of viscosity, and amplitude has a greater impact on maximum power consumption than on average power consumption. These correlations were then compared with available power models (that showed an acceptable level of discrepancies) in the literature. Lower power consumption values obtained from CFD results compared to those obtained from quasi‐steady state model (QSM) and eddy enhancement model (EEM) models (developed for stationary baffle OBRs) under the same operating conditions, along with higher axial dispersion of moving baffle OBRs compared to stationary baffle types under the same operating conditions, indicated that a moving baffle OBR is a more efficient mixing device than a stationary baffle OBR in terms of power consumption. The ratio of average power consumption to maximum power consumption was proven to be independent of the type of fluid and a very weak function of oscillation frequency.
SupportedTiO2/silica gel as an efficient and inexpensive catalyst for nonsolvent liquid‐phase oxidation of cyclohexylamine to cyclohexanone oxime
Authors: Liu Shuilin , Liu Ning , Li Aiyang , Wu Suyun , Luo Jianghuan , Tang Xinde 
Published: September 2022

AbstractA benign approach is proposed for the highly efficient synthesis of cyclohexanone oxime through nonsolvent liquid‐phase oxidation of cyclohexylamine with dioxygen over supported TiO2/silica gel. The as‐prepared catalyst was characterized by Brunauer–Emmett–Teller (BET), Fourier‐transform infrared spectroscopy (FT‐IR), scanning electron microscope (SEM), X‐ray photoelectron spectroscopy (XPS), and X‐ray powder diffraction (XRD) analyses. The results indicate that titanium active sites could be grafted on silica gel supports as catalytic centres. Various parameters such as reaction time and reaction temperature were systematically optimized; the results showed that supported 20%TiO2/silica gel exhibited the best catalytic effect with 63.2% of amine conversion and 86.3% of selectivity to CHO. A possible pathway is proposed for cyclohexylamine oxidation over supported TiO2/silica gel. The method developed in this study using dioxygen as the oxidant and inexpensive TiO2/silica gel as an efficient catalyst has incredible industrial application potential for green synthesis of cyclohexanone oxime.
Degradable cationic clarifiers based on ester bonds for treating wastewater produced from polymer flooding
Authors: Wang Xiujun , Zhang Jian , Huang Bo , Duan Ming 
Published: September 2022

AbstractPolymer‐contained oily sludge is inevitably produced when the oily wastewater produced from polymer flooding (OWPF) is treated by a cationic polymer clarifier, and it severely affects oilfield production. This study designed a novel degradable cationic clarifier (DCC) based on the ester bond and prepared it in light of the poly(β‐amino ester) used in the area of generic material delivery. First, the copolymer of N‐[3‐(dimethylamino) propyl] methacryamide (DMAPMA) and diallylamine (PDMAPMA‐NH) were synthesized by radical copolymerization. Then, the DCC was prepared by Michael addition between PDMAPMA‐NH and poly(ethylene glycol) diacrylate. The synthesis conditions of DCC were investigated, and a DCC with excellent flocculant performance and good degradability was successfully prepared. At 70°C, both the degradations of DCC and the water‐insoluble polymer complex formed by DCC and the polymer used for polymer flooding can be completed in 10 h, which is beneficial for the self‐disappearance of the polymer‐contained oily sludge. The flocs formed by DCC were observed at different times, and the results confirmed that the flocs can change to an oil film and that the polymer‐contained oily sludge cannot exist for a long time. This study provides inspiration for OWPF treatment and expands the new application for poly(β‐amino ester).
Preparation of propylene carbonate by alcoholysis of urea from the perspective of homogeneous reaction: Influence of dissolution and precipitation of metal oxide catalysts
Authors: Yang Fei , Shen Weihua , Fang Yunjin 
Published: September 2022

AbstractThe dissolution process of metal oxide catalysts in the alcoholysis of urea by 1, 2‐propylene glycol (PG) to the synthesis of propylene carbonate (PC) was investigated. It was found that the reaction was mainly catalyzed by homogeneous catalysts. The metal oxide reacted with ammonia and isocyanate acid, the decomposition products of urea, to form a complex and dissolved into the reaction system. The dissolved amount of catalyst was positively correlated with the PC yield by using different oxides and salts as catalysts. The Fourier‐transform infrared spectroscopy (FTIR) result of the catalysts reacting with urea showed that the dissolution‐precipitation process of the catalysts was related to the decomposition of urea. The results of catalytic test indicated that both the dissolved amount of catalysts and the structure of the complex affected PC yields. A reaction mechanism was proposed based on the results. From the mechanism, a complex catalyst with at least two ammonia ligands is better for this reaction.
Selective hydrogenation of oleic acid to fatty alcohols using Rh‐Sn‐B/TiO2 catalysts: Influence of Sn content
Authors: Fonseca Benítez Cristhian A. , Mazzieri Vanina A. , Sánchez María A. , Vicerich María A. , Benitez Viviana M. , Pieck Carlos L. 
Published: September 2022

AbstractThe influence of the catalyst Sn content on the production of fatty alcohol from oleic acid by selective hydrogenation was studied using Rh‐Sn‐B catalysts supported on TiO2. The crystal phase of the support was analyzed by X‐ray diffraction (XRD), the reduction state of the metal phase by temperature‐programmed reduction (TPR), and the electronic state of surface species by X‐ray photoelectron spectroscopy (XPS). The metal activity was evaluated by the dehydrogenation of cyclohexane. It was found that the increase in Sn content leads to a proportional drop in the catalytic activity, which could be related to a metallic interaction between Rh and Sn, as shown by TPR. Oxide and metallic Sn, as well as Rh0 and Rh3+, were found by XPS on the catalyst surface. Metallic Rh was, however, found in higher concentration than oxidized Rh in all cases. The yield to fatty alcohols increased with Sn content, and its maximum value for oleyl and stearyl alcohol was 96%. Furthermore, a higher yield (88.3%) was obtained out of unsaturated fatty alcohol (oleyl alcohol), which has proved to be more valuable than saturated alcohol. This was attributed to an adequate Rh/Sn ratio, which modulates the hydrogenating activity of Rh and makes the metal function more selective for hydrogenation of the carbonyl group. The influence of the support on the catalyst performance decreases as the Sn content increases. The support has a practically negligible influence on the catalyst activity for 4–5 wt.% of Sn content.
A remote hypertension management program clinical algorithm
Authors: Nichols Hunter , Cannon Christopher P. , Scirica Benjamin M. , Fisher Naomi D. L. 
Published: September 2022

AbstractIntroductionHypertension is the leading risk factor for death, affecting over one billion people worldwide, yet control rates are poor and stagnant. We developed a remote hypertension management program that leverages digitally transmitted home blood pressure (BP) measurements, algorithmic care pathways, and patient–navigator communications to aid patients in achieving guideline‐directed BP goals.MethodsPatients with uncontrolled hypertension are identified through provider referrals and electronic health record screening aided by population health managers within the Mass General Brigham (MGB) health system. Non‐licensed patient navigators supervised by pharmacists, nurse practitioners, and physicians engage and educate patients. Patients receive cellular or Bluetooth‐enabled BP devices with which they monitor and transmit scheduled home BP readings. Evidence‐based medication changes are made according to a custom hypertension algorithm approved within a collaborative drug therapy management (CDTM) agreement with MGB and implemented by pharmacists.Using patient‐specific characteristics, we developed different pathways to optimize medication regimens. The renin–angiotensin–aldosterone system‐blocker pathway prescribed ARBs/ACE inhibitors first for patients with diabetes, impaired renal function, and microalbuminuria; the standard pathway started patients on calcium channel blockers. Regimens were escalated frequently, adding thiazide‐type diuretics, and including beta blockers and mineralocorticoid receptor antagonists if needed.DiscussionWe have developed an algorithmic approach for the remote management of hypertension with demonstrated success. A focus on algorithmic decision‐making streamlines tasks and responsibilities, easing the potential for scalability of this model. As the backbone of our remote management program, this clinical algorithm can improve BP control and innovate the management of hypertension in large populations.
Rapeseed Oil Based Oleogels for the Improvement of the Fatty Acid Profile Using Cookies as an Example
Authors: Schubert Madline , Erlenbusch Nelli , Wittland Sebastian , Nikolay Sharline , Hetzer Birgit , Matthäus Bertrand 
Published: September 2022

AbstractIn this study rapeseed oil based oleogels with sunflower wax, ethyl cellulose, monoacylglycerols, or mixtures of it as oleogelators are characterized in comparison to conventional bakery margarines or partially hydrogenated peanut fat with regard to their oil‐binding capacity, hardness, and rheological behavior. Oleogels prepared with 5% and 10% sunflower wax and 5% monoacylglycerols with 5% ethyl cellulose, respectively, show comparable properties as the conventional fat phases with regard to the mentioned parameters. The rheological properties reveal that storage and loss moduli of oleogels prepared without sunflower wax are significantly lower in comparison to conventional margarines. In addition, cross‐sectional views allow a very deep insight in the 3D structure of the oleogels via cryogenic scanning electron microscopy. For oleogels consisting of ethyl cellulose, entrapped oil droplets can be visualized and the pore size distribution is established by a semiautomatic approach. The use of oleogels results in a reduction of saturated fatty acids from 29%–47% to 7%–13% and in an increase of polyunsaturated fatty acids of at least 22% in oleogel‐based cookies. Cookies prepared with oleogels are accepted by the consumer, even if the overall evaluation is slightly worse in comparison to the conventional products.Practical Applications: The application of rapeseed oil based oleogels with sunflower wax, ethyl cellulose, monoacylglyerols, or mixtures is a very good possibility to replace fat phases in bakery products high in saturated fatty acids and to improve the fatty acid profile of the foods. This results in food with a higher content of monounsaturated oleic acid and polyunsaturated linolenic acid recommended for a healthier nutrition.
Determination of nitroimidazole antibiotics based on dispersive solid‐phase extraction combined with capillary electrophoresis
Authors: Yang Jing , Chen Lianfang , Wang Qingying , Mei Xiaolin , Yang Xiupei , Huo Feng 
Published: September 2022

AbstractFor a long time, the detection of nitroimidazole antibiotics (NIABs) has been a research focus in environmental analytical chemistry. In this work, a novel technique for the analysis of nitroimidazoles was established based on capillary electrophoresis (CE). UiO‐66, synthesized using a solvothermal method, was utilized as an adsorbent in the dispersive solid‐phase extraction (DSPE) of five different NIABs. The separation and detection of NIABs in environmental water samples were accomplished using the CE diode array detection method. The optimal extraction conditions were obtained after systematically studying the effects of adsorption time, the amount of extractant, and elution solvent on extraction efficiency. According to the results of the study, the limit of detections of the five NIABs were between 16 and 97 ng/mL, the relative standard deviations were between 0.32% and 0.55%, and the spike recoveries were between 87.43% and 104.8%. This study presents a novel technique for measuring NIABs in complex water samples.
Taylor dispersion analysis of metallic‐based nanoparticles – A short review
Authors: Gouyon Jeremie , Boudier Ariane , Barakat Fatima , Pallotta Arnaud , Clarot Igor 
Published: September 2022

AbstractTaylor dispersion analysis (TDA) is an interesting tool for nanoparticle (NP) size determination, feasible using simple capillary electrophoresis apparatus. Based upon the radial diffusion of analytes upon a laminar stream, the diffusion coefficient of species is easily estimable. Moreover, TDA is generally more adequate than conventional dynamic light scattering methodologies as it is less dependent on the polydispersity of the sample, leading to accurate measurement and reliable results. This review provides every paper mentioning the use of TDA for metallic‐based NPs size determination. Diverse strategies for the detection of metallic NPs (like UV–visible and inductively coupled plasma–mass spectrometry – ICP–MS – for instance) and interpretation of the Taylorgrams are discussed. Based upon the literature, advices on future prospects are also indicated, especially for the comparison of TDA results with other classical techniques.
‘It makes you not want to eat’: Perceptions of anti‐obesity public health campaigns in individuals diagnosed with an eating disorder
Authors: Bristow Claire , Simmonds Janette , Allen Kelly‐Ann , McLean Louise 
Published: September 2022

AbstractObjectiveRecent research has highlighted the potentially deleterious effects of anti‐obesity public health campaigns on vulnerable audiences such as those at risk of, or diagnosed with, eating disorders (ED). The qualitative experiences of campaigns in this population group have been little explored.MethodsTwelve interviews were conducted with participants either currently or previously diagnosed with an ED using the Interpretative Phenomenological Analysis approach. Participants were shown a series of real‐world public health campaigns and, using a semi‐structured interview guide, asked about their responses to the images used.ResultsSeveral themes emerged from the data, including the effect of campaigns on participants, perceived effect on others, and general campaign attributes. It was evident that participants felt that anti‐obesity campaigns had the potential to confirm ED thoughts and behaviours, and could act as potential triggers. Participants also felt that they could impact vulnerable groups (e.g., young audiences) and stigmatise those living in larger bodies.ConclusionCampaigns addressing overweight and obesity should consider reframing these conditions and care must be taken to avoid causing potential harm to vulnerable audiences.
Modeling and operation optimization of mine integrated energy system under variable conditions of typical equipment
Authors: Zhang Yong , Wu Xiaokang , Hu Hejuan , Sun Xiaoyan , Gong Dunwei 
Published: September 2022

AbstractMine integrated energy system (MIES) promotes the utilization of derived energy, multienergy complementation, and ecological protection, but the variable condition characteristics of key energy conversion equipment bring challenges to its operation optimization. Focused on this, the paper studies a MIES operation optimization model with integrated demand response under variable conditions of typical equipment. First, analyzing the coupling utilization mode of mine energy flow, a MIES operation structure including mine derived‐energy utilization and integrated demand response is constructed. Second, considering the supply characteristics of different derived energy sources, the variable condition dynamic energy efficiency model of typical energy conversion equipment is established. Furthermore, considering the flexible and controllable characteristics of multienergy loads, an integrated demand response mechanism including electric and thermal flexible loads is formed. Finally, the operation optimization model of MIES is constructed with the goal of the lowest operating costs of the system. The GUROBI solver is applied to solve the model, and experimental results under different operating scenarios show that the established MIES operation optimization model effectively improves the economy of system operation.
Study on the hypolipidemic effect of Inonotus obliquus polysaccharide in hyperlipidemia rats based on the regulation of intestinal flora
Authors: Lin Fengyuan , Li Xiao , Guo Xiao , Lu Xuechun , Han Xiao , Xu GuangYu , Du Peige , An Liping 
Published: September 2022

AbstractThe purpose of this study was to observe the effect of Inonotus obliquus polysaccharide (IOP) on blood lipids and its regulation on the intestinal flora in hyperlipidemia rats, and explore the modern biological connotation of IOP in reducing blood lipids. In this study, we obtained the crude IOP by the water extraction and alcohol precipitation method, and then classified it by DEAE ion‐exchange chromatography to obtain the acidic I. obliquus polysaccharide (IOP‐A). After the administration of the IOP‐A, the serum TC, TG, and LDL‐C levels were significantly lower, while the serum HDL‐C levels were significantly higher. The expression of CYP7A1 protein was considerably increased, whereas the expression of SREBP‐1C protein was considerably decreased in the rat hepatic tissue. In addition, the IOP‐A could significantly alleviate the hepatocyte fatty degeneration in the liver lobule of rats. We believe that the IOP‐A can affect the composition of intestinal flora by reducing the relative abundance of Firmicutes and increasing the relative abundance of Bacteroidetes. These findings indicated that the IOP‐A can regulate the dyslipidemia of hyperlipidemia rats, and its mechanism may be through regulating the CYP7A1 and SREBP‐1C expression in the metabolism of lipids, and correcting the imbalance of intestinal flora structure caused by a high‐fat diet.
Optimization of protein removal process of Lonicera japonica polysaccharide and its immunomodulatory mechanism in cyclophosphamide‐induced mice by metabolomics and network pharmacology
Authors: Ding Jie , Du Haitao , Tan Haining , Li Jing , Wang Lingna , Li Li , Zhang Yongqing , Liu Yuhong 
Published: September 2022

AbstractIn this study, TCA–n‐butanol was chosen as the best deproteinization method for Lonicera japonica polysaccharide (LJP) by comparing the polysaccharide retention rate and the protein clearance rate of five different methods. The response surface methodology (RSM) based on the Box–Behnken design (BBD) was used to optimize the deproteinization conditions as follows: TCA: n‐butanol = 1: 5.1, polysaccharide solution: (TCA–n‐butanol) = 1: 2.8, and shook for 33 min. LJP could promote the thymus and spleen indexes of cyclophosphamide (CTX)‐induced immune‐deficient mice. Besides, the contents of cytokine interleukin‐2 (IL‐2) and hemolysin in mice serum were augmented after treatment with LJP. Based on serum metabolomics analysis, a total of 14 metabolites (VIP >1.0, FC >2 or FC <0.5, and p value < .05) were selected as the potential biological biomarkers related to the LJP for treating CTX‐induced mice. After the pathway enrichment analysis, these metabolites were mainly involved in the relevant pathways of arginine biosynthesis, Citrate cycle, and other metabolic pathways. Network pharmacology further showed that there were 57 key targeting proteins in the intersection of the potential biological biomarkers and immunodeficiency‐related targeting proteins according to protein–protein interactions analysis (PPI). The biological function analysis indicated that the potential biological processes were mainly associated with tricarboxylic acid (TCA) cycle, phospholipid metabolic process, metabolic process, and so on. In conclusion, serum metabolomics combined with network pharmacology could be helpful to clarify the immunomodulatory mechanism of LJP and provide a literature basis for further clinical research on the therapeutic mechanism of LJP.
Loss of phospholipase Cγ1 suppresses hepatocellular carcinogenesis through blockade of STAT3‐mediated cancer development
Authors: Seo Eun‐Bi , Jang Hyun‐Jun , Kwon Sun‐Ho , Kwon Yong‐Jin , Kim Seul‐Ki , Lee Song‐Hee , Jeong Ae Jin , Shin Hyun Mu , Kim Yong‐Nyun , Ma Stephanie , Kim Haeryoung , Lee Yun‐Han , Suh Pann‐Ghill , Ye Sang‐Kyu 
Published: September 2022

Abstract
Phospholipase C gamma 1 (PLCγ1) plays an oncogenic role in several cancers, alongside its usual physiological roles. Despite studies aimed at identifying the effect of PLCγ1 on tumors, the pathogenic role of PLCγ1 in the tumorigenesis and development of hepatocellular carcinoma (HCC) remains unknown. To investigate the function of PLCγ1 in HCC, we generated hepatocyte‐specific PLCγ1 conditional knockout (PLCγ1f/f; Alb‐Cre) mice and induced HCC with diethylnitrosamine (DEN). Here, we identified that hepatocyte‐specific PLCγ1 deletion effectively prevented DEN‐induced HCC in mice. PLCγ1f/f; Alb‐Cre mice showed reduced tumor burden and tumor progression, as well as a decreased incidence of HCC and less marked proliferative and inflammatory responses. We also showed that oncogenic phenotypes such as repressed apoptosis, and promoted proliferation, cell cycle progression and migration, were induced by PLCγ1. In terms of molecular mechanism, PLCγ1 regulated the activation of signal transducer and activator of transcription 3 (STAT3) signaling. Moreover, PLCγ1 expression is elevated in human HCC and correlates with a poor prognosis in patients with HCC. Our results suggest that PLCγ1 promotes the pathogenic progression of HCC, and PLCγ1/STAT3 axis was identified as a potential therapeutic target pathway for HCC.