bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiscale Sensitivity Analysis of Hydraulic Fracturing Parameters Based on Dimensionless Analysis Method
Authors: Luo Haoran , Xie Jun , Huang Liuke , Wu Jianfa , Shi Xuewen , Bai Yuesong , Fu Haifeng , Pan Bing 
Published: June 2022

Abstract
The optimal design of hydraulic fracturing parameters is the key to commercial exploitation of unconventional reservoirs. Hydraulic fracturing test is one of the main methods for optimizing fracturing parameters. It is known that scale effect exists between laboratory experiments and field treatments of hydraulic fracturing. However, studies on how to eliminate the scale effect are rarely reported. In this work, we conduct sensitivity analysis on rock mechanical parameters and fracturing parameters at different scales by using the dimensionless analysis method. The initiation and propagation process of field hydraulic fracturing is reproduced through laboratory tests, and fracturing parameters are analyzed by using numerical simulation. Our results show that the fracture propagation in the laboratory is inconsistent with that in the field fracturing. The fracture initiation and propagation in the field can be reproduced in experiments by using samples with high modulus and low toughness as well as high-viscosity fracturing fluid. Microcracks are created before the breakdown pressure is reached, and hydraulic fractures extend perpendicular to the direction of the minimum principal stress. The Carter’s leak-off coefficient has little effect on breakdown pressure and propagation pressure, but the injection rate and the horizontal principal stress have significant effects on breakdown pressure. This study provides a theoretical basis and guidance for the design of fracturing parameters both in the laboratory and in the field.
Evaluasi Usabilitas Layanan Sistem Informasi Akademik Menggunakan Metode Webqual
Authors: Dimuksa Wira 
Published: June 2022

Penelitian ini bertujuan untuk melakukan evaluasi usabilitas layanan Sistem Informasi Akademik (SIAKAD) STKIP PGRI Pacitan menggunakan metode WebQual 4.0. Untuk mengetahui seberapa signifikan pengaruh kualitas layanan SIAKAD terhadap kepuasan pengguna penelitian ini menggunakan regresi linier berganda, sedangkan untuk mengetahui kesenjangan antara harapan pengguna dan kinerja sistem digunakan metode Importance Performance Analysis. Teknik pengambilan sampel pada penelitian ini menggunakan stratified sampling dan teknik solvin untuk penarikan sampel hingga diperoleh 208 responden yang terdiri dari perwakilan tiap prodi.
Dari hasil analisis regresi linier berganda, masing-masing variabel independen ditemukan memiliki nilai thitungttabel dan nilai Sighit sebesar 0,000 Sigprob yang bernilai 0,05 maka bisa dikatakan variabel Usability, Information Quality, dan Interaction Quality memiliki pengaruh terhadap kepuasan pengguna SIAKAD. Sedangkan pada Importance Performance Analysis didapatkan indikator X1.5, X2.5, dan X3.6 berada pada kuadran satu, dengan gap masing-masing -1,16, -0,87, dan -2,58.
Dari variabel kualitas layanan yang terdapat pada WebQual 4.0 masing-masing memiliki pengaruh yang signifikan terhadap User Satisfaction SIAKAD di STKIP PGRI Pacitan, ini berarti bahwa semakin baik kualitas pelayanan SIAKAD yang diberikan oleh STKIP PGRI Pacitan kepada mahasiswa, maka akan meningkatkan citra lembaga di mata mahasiswa. Perlu adanya perbaikan pada indikator X1.5, X2.5, dan X3.6 agar kinerja dari SIAKAD dapat memenuhi harapan dari pengguna, terutama pada variabel Interaction karena memiliki nilai gap terbesar yakni -0,89.
Projection into the future: combination of orphenadrine and diclofenac in patients with bone metastases
Authors: Abuzarova G. R. , Sarmanaeva R. R. , Kuznetsov S. V. , Bychkova N. M. , Brazhnikova Yu. V. 
Published: June 2022

Introduction. Radiation therapy is an effective method of treating pain in patients with bone metastases, but during radiotherapy there is often an increase in pain. The presence of a new drug containing a combination of orphenadrine and diclofenac in oncologists expands the possibilities of analgesia.Aim. To evaluate the efficacy and safety of the use of a fixed combination of diclofenac and orphenadrine in patients with pain due to metastatic bone damage during radiotherapy.Materials and methods. The patients were randomized into two groups: the first group (n = 30) received the drug Neodolpasse intravenously once a day for two days; the second - 2 times a day (n = 30) - 2 days. Efficacy was evaluated based on the following measurements: intensity of pain by NRS immediately after administration of the drug, after 30 minutes, after 1, 2, 4 and 24 hours, the dynamics of daily doses of analgesics.Results and discussion. In group 1, a meaningful decrease in pain intensity (p < 0.05) from 48.7 ± 10.6 mm to 26.8 ± 10.7 mm was achieved 30 minutes after the completion of infusion. The pain intensity measured by the Numeric Rating Scale (NRS) reached its minimum value 2 hours after the completion of infusion (22.5 ± 12.0 mm). In group 2, the pain intensity decreased 30 minutes after the completion of infusion, a meaningful decrease (p < 0.05) in pain intensity was achieved from 56.5 ± 9.8 mm to 34.0 ± 10.5 mm, and up to 29.8 ± 10.2 mm after the second dose. The pain intensity decreased by 45.9% in group 1 and by 47.9% in group 2 towards the end of the Neodolpasse therapy cycle. During the study, two mild to moderate adverse events (nausea, drop in blood pressure) that did not require any significant drug therapy were observed.Conclusion. The results of the study confirm that the use of the drug according to the proposed method is a safe and effective way of treating pain syndrome during radiotherapy in patients with metastatic bone damage.
Olaparib maintenance therapy after frontline chemotherapy in patients with BRCA-mutated ovarian cancer: real-world results in expanded access program
Authors: Rumyantsev A. A. , Tyulyandina A. S. , Pokataev I. A. , Israelyan E. R. , Abramov M. Е. , Lud H. N. , Tyulyandin S. A. 
Published: June 2022

Introduction. Olaparib is the only PARP inhibitor approved in Russia for the maintenance therapy for BRCA-positive ovarian cancer after frontline chemotherapy. We conducted a real-world analysis of olaparib efficacy and safety for this indication.Aim. To assess the efficacy of PARP inhibitors in real-world clinical practice.Materials and methods. Patients with stage III-IV BRCA-mutated ovarian cancer who received olaparib maintenance therapy in expanded access program in 03.2019-12.2020 timeframe. Briefly, key inclusion criteria were: serous or endometrioid highgrade ovarian cancer; pathogenic BRCA1/2 mutation; primary or interval debulking; complete or partial response to frontline platinum-based therapy. Olaparib was administered as tablets (300 mg BID) up to 2-years, disease progression or unacceptable toxicity, whichever occurred first. The primary endpoint of the study was progression-free survival (PFS), overall survival (OS) and safety were key secondary endpoints. Statistical analysis was done with R and RStudio software.Results and discussion. 23 patients were enrolled. Median age was 49 years, all patients had high-grade serous adenocarcinoma histology. Complete debulking at primary or interval surgery was achieved in 30% of patients. With median follow-up time equal to 22 months, median PFS and OS were not reached. The 2-year PFS and OS were 65 and 84%, respectively. Grade 3-4 adverse events was detected in 7 (30.4%) patients.Conclusion. Our results supports high efficacy of olaparib in real clinical practice setting reported in the SOLO1 trial.
Polyvinyl Alcohol can Stabilize FITC Conjugated Recombinant Annexin V
for Apoptotic Cells Detection
Authors: Shobeiri Saeideh Sadat , Sankian Mojtaba 
Published: June 2022

Background:
Annexin V, a member of calcium-dependent phospholipid-binding proteins, selectively binds to the exposed phosphatidylserine, which can be used for in vitro apoptosis detection. Simultaneous staining of cells with annexin V-fluorescein isothiocyanate (FITC) and the non-vital dye propidium iodide (PI) enables detection of apoptotic and necrotic cells.

Objective:
Our study aimed to express, purify, and stabilize the recombinant annexin V.

Method:
The recombinant annexin V was cloned and expressed in E. coli bacteria and was purified using Ni-IDA resin. The FITC conjugation was performed, and apoptosis detection of HaCaT cells by FITC-labeled annexin V was evaluated by flow cytometry. Then, the stability of FITC-labeled annexin in various conditions, including polyvinyl alcohol (PVA), glycerol, and trehalose, was evaluated.

Results:
The results showed that annexin V was appropriately expressed and purified. After FITC conjugation, it could perfectly detect the cell death of HaCat cells in different apoptosis percentages. FITC-labeled annexin had more stability with PVA than glycerol and trehalose.

Conclusion:
It seems that PVA has an acceptable effect on FITC-labeled annexin V stability in concentrations lower than 1 mg mL-1, without interfering in fluorescent intensity.
Sodium-glucose Cotransporter Type 2 Inhibitors: A New Insight into the Molecular
Mechanisms of Diabetic Nephropathy
Authors: Li Na , Zhou Hong 
Published: June 2022

Abstract:
Diabetic nephropathy is one of the chronic microvascular complications of diabetes and is a leading
cause of end-stage renal disease. Fortunately, clinical trials have demonstrated that sodium-glucose cotransporter
type 2 inhibitors could decrease proteinuria and improve renal endpoints and are promising agents for the
treatment of diabetic nephropathy. The renoprotective effects of sodium-glucose cotransporter type 2 inhibitors
cannot be simply attributed to their advantages in aspects of metabolic benefits, such as glycemic control, lowering
blood pressure, and control of serum uric acid, or improving hemodynamics associated with decreased
glomerular filtration pressure. Some preclinical evidence suggests that sodium-glucose cotransporter type 2 inhibitors
exert their renoprotective effects by multiple mechanisms, including attenuation of oxidative and endoplasmic
reticulum stresses, anti-fibrosis and anti-inflammation, protection of podocytes, suppression of megalin
function, improvement of renal hypoxia, restored mitochondrial dysfunction and autophagy, as well as inhibition
of sodium-hydrogen exchanger 3. In the present study, the detailed molecular mechanisms of sodiumglucose
cotransporter type 2 inhibitors with the actions of diabetic nephropathy were reviewed, with the purpose
of providing the basis for drug selection for the treatment of diabetic nephropathy.
Neoadjuvant Endocrine Therapy: A Potential Way to Make Cold
Hormone Receptor-Rich Breast Cancer Hot
Authors: Zhang Suzhan , Hu Yue , Hu Kaimin , Wu Yinan , Gong Xiaonan , Wang Kaiyue , Yu Chengcheng , Qiu Jili 
Published: June 2022

Background:
Turning the “cold” tumor immune microenvironment into “hot” is a critical
issue in cancer treatment today. Hormone receptor-rich breast cancer (HR+ BC) was previously
considered immunologically quiescent.

Objective:
This study aims to explore the immunomodulatory effects of endocrine therapy on HR+
BCs.

Methods:
The infiltrations and alterations of the tumor immune microenvironment in HR+ BCs before,
after 10-14 days, and after three months of neoadjuvant endocrine therapy were computationally
analyzed according to MCP-counter, CIBERSORT, xCell algorithms, and gene-set enrichment
analysis (GSEA). The primary microarray data were obtained from three HR+ BC gene expression
datasets (GSE20181, GSE55374, and GSE59515). Single-sample GSEA of hallmark and immune
response gene sets was performed to evaluate the correlation between suspected treatment response
and activated immune pathways in tumors.

Results:
Both immune and stromal cells were specifically recruited into the HR+ BCs who responded
to the neoadjuvant endocrine therapy by letrozole. Besides the enhanced infiltrations of
immunosurveillance-related cells such as CD8+ T cells, dendritic cells, and the activation of immune
response-related signals, the immunosuppressive M2-like macrophages, as well as the expression
of immune checkpoint genes like PDCD1, SIRPA, and some HLA genes, were also stimulated
in responders. We identified four pretreatment indicators (the intrinsic luminal subtype, the
estrogen response early/late pathway, and the epithelial-mesenchymal transition pathway) as
potential predictors of both clinical response and the activation of the tumor immune microenvironment
post letrozole.

Conclusions:
Neoadjuvant endocrine therapy showed a promising way to convert the immunologically
“cold” HR+ BCs into “hot” tumors. This study provides new insights into the application of
immunotherapy for HR+ BCs, especially those who respond to endocrine therapy.
Adult-onset and Juvenile-onset Still’s Disease: A Comparative Study of
Both Sides
Authors: Aicha Ben Tekaya , Emna Hannech , Olfa Saidane , Selma Bouden , Leila Rouached , Rawda Tekaya , Ines Mahmoud , Slim Abdelmoula , Leila Abdelmoula 
Published: June 2022

Background:
Adult-onset Still’s disease and systemic-onset juvenile idiopathic arthritis constitute two sides of the same continuum disease. We aimed to investigate the similarities and dif-ferences between those diseases.

Methods:
We conducted a retrospective study including adult patients affected by still’s disease, at-tending the rheumatology department and patients affected by systemic-onset juvenile idiopathic arthritis attending the pediatric department. We recorded clinical and radiological findings, different therapeutic regimens, and disease patterns.

Results:
There were 8 adult patients (6 females and 2 males) and 8 juvenile patients (4 females and 4 males). The classical triad of spiking fever, arthritis, and evanescent skin rash was the first clinical presentation observed in 4 adult patients and in 2 juvenile patients. Arthritis was noted in 8 adult pa-tients versus 6 juvenile patients. Joint deformities were seen in adult patients. Non-steroid anti-inflammatory drugs and corticosteroids were the most prescribed molecules. csDMARDs and bDMARDs were used in second-line therapy only for adult patients. The monocyclic course was predominant in juvenile patients and the polycyclic course in adult patients. The chronic course was observed only in two adult patients. Remission was noted in 5 adult patients and 6 juvenile patients. There were no significant differences between the two groups regarding clinical findings, different therapeutic regimens, and disease patterns.

Conclusion:
From the findings of our study, it seems that AOSD and sJIA are the same syndrome continuum expressed in different hosts. This hypothesis is supported by clinical course, molecule evidence, cytokine profile, and treatment response.
Colored Edge Detection Using Thresholding Techniques
Authors: Fenyi Adolf , Fenyi Isaac , Asante Michael 
Published: June 2022

Background:
In this research, a novel algorithm is formulated through the combination of gradient
and adaptive thresholding. A set of 5 X 5 convolution kernels were generated to determine the gradients in the
four main directions of the image

Objectives:
The researcher converted the gaussian equation into a normalized kernel, which was convolved
with the gradients to suppress the impact of noise

Methods:
The edges derived were partitioned into a set of 5 x 5 matrices. A weighted variance was calculated
for each local window in the image. The pixel that generated the minimum variance was used for the
segmentation process in each local window. The researcher then trimmed multiple pixel width edges into
singles by developing a set of 5 X 5 Structuring Elements (SE). These elements were placed over the image to
remove boundary pixels. In order to produce colored edges, the algorithm was executed over all the channels
and the results were concatenated to produce the skeletal colored edges.

Results:
From the evaluations conducted, the proposed algorithm exhibited better performance than most of
the recent algorithms with respect to Human Perception Clarity and time complexity in both noisy and nonuniform illuminated images.

Conclusion:
The reason for this performance is that it is able to extract edges moving in the various directions
of images. It also ensures that identified edges are single pixel width instead of multiple.
COVID-box Experiences of Patients and Health Care Professionals (COVID-box Project): Single-Center, Retrospective, Observational Study
Authors: Dirikgil Ebru , Brons Kim , Duindam Michael , Groeneveld Geert H , Geelhoed J J Miranda , Heringhaus Christian , van der Boog Paul J M , Rabelink Ton J , Bos Willem Jan W , Chavannes Niels H , Atsma Douwe E , Teng Y K Onno 
Published: June 2022

Background
During the COVID-19 pandemic, several home monitoring programs have described the success of reducing hospital admissions, but only a few studies have investigated the experiences of patients and health care professionals.

Objective
The objective of our study was to determine patients’ and health care professionals’ experiences and satisfaction with employing the COVID-box.

Methods
In this single-center, retrospective, observational study, patients and health care professionals were asked to anonymously fill out multiple-choice questionnaires with questions on a 5-point or 10-point Likert scale. The themes addressed by patients were the sense of reassurance and safety, experiences with teleconsultations, their appreciation for staying at home, and the instructions for using the COVID-box. The themes addressed by health care professionals who treated patients with the COVID-box were the characteristics of the COVID-box, the technical support service and general satisfaction, and their expectations and support for this telemonitoring concept. Scores were interpreted as insufficient (≤2 or ≤5, respectively), sufficient (3 or 6-7, respectively), or good (≥4 or ≥8, respectively) on a 5-point or 10-point Likert scale.

Results
A total of 117 patients and 25 health care professionals filled out the questionnaires. The median score was 4 (IQR 4-5) for the sense of safety, the appreciation for staying at home, and experiences with teleconsultations, with good scores from 76.5% (88/115), 86% (56/65), and 83.6% (92/110) of the patients, respectively. Further, 74.4% (87/117) of the patients scored the home monitoring program with a score of ≥8. Health care professionals scored the COVID-box with a minimum median score of 7 (IQR 7-10) on a 10-point scale for all domains (ie, the characteristics of the COVID-box and the technical support service and general satisfaction). For the sense of safety, user-friendliness, and additional value of the COVID-box, the median scores were 8 (IQR 8-10), 8 (IQR 7-9), and 10 (IQR 8-10), respectively, with good scores from 86% (19/22), 75% (15/20), and 96% (24/25) of the health care professionals, respectively. All health care professionals (25/25, 100%) gave a score of ≥8 for supporting this home monitoring concept, with a median score of 10 (IQR 10-10).

Conclusions
The positive experiences and satisfaction of involved users are key factors for the successful implementation of a novel eHealth solution. In our study, patients, as well as health care professionals, were highly satisfied with the use of the home monitoring program—the COVID-box project. Remote home monitoring may be an effective approach in cases of increased demand for hospital care and high pressure on health care systems.
Pertambangan emas tanpa izin (PETI) dan kesejahteraan keluarga di sekitar wilayah pertambangan
Authors: Junaidi Junaidi 
Published: June 2022

This study aims to 1) analyze the impact of illegal gold mining (IGM) on social, economic, and environmental conditions as well as the problems faced by families in the IGM area; 2) Formulate strategies for handling the impact of IGM on family welfare. The research was conducted in Pangkalan Jambu District, Merangin Regency, Jambi Province. The type of data used is primary data sourced from family respondents and informants in the area around mining. Data were collected through questionnaires, in-depth interviews, and Focus Group Discussions (FGD). The results of the analysis found that IGM activities in general have been able to grow new job opportunities and increase people's income. However, from social and environmental aspects, there are various negative impacts of IGM on family welfare. Therefore, in dealing with the impact of IGM on family welfare, three policy strategies are recommended, namely: 1) increasing family capacity; 2) strengthening the values ​​of local wisdom and social capital in society; 3) People's Mining Area and Small-Scale Mining programs.
Keywords: Family welfare, Illegal gold mining, Income shock
Analisis Faktor Risiko Lingkungan Terhadap Kejadian Filariasis di Kabupaten Tanjung Jabung Timur
Authors: Jumiati Jumati , Kalsum Ummi , Ilham Ilham 
Published: June 2022

Kabupaten Tanjung Jabung Timur merupakan kabupaten endemis Filariasis. Angka Mikrofilaria rate (Mf rate) tahun 2018 adalah 1,33% dan merupakan satu-satunya kabupaten/kota di Provinsi Jambi dengan angka Mf rate > 1%, sehingga dilakukan pengobatan massal kembali selama 2 tahun (2017-2018), namun masih ditemukan kasus baru pada tahun 2019. Tujuan Penelitian adalah menganalisis hubungan lingkungan fisik, biologi, sosial dan budaya dengan kejadian filariasis dan faktor dominan terhadap kejadian filariasis. Penelitian ini bersifat kuantitatif dengan rancangan case control. Populasi adalah kasus filariasis Tahun 2012-2018 di Kabupaten Tanjung Jabung Timur. Jumlah sampel sebanyak 80 orang, dengan perbandingaan antara kasus dan kontrol 1:1. Instrumen penelitian berupa kuesioner. Analisis data menggunakan Chi-square test dan Independen sample t-test serta regresi logistik ganda. Hasil analisis terdapat 4 variabel yang terbukti berpengaruh terhadap kejadian filariasis yaitu: umur responden (OR=0,14 CI 95% (0,05-0,38), pendidikan responden (OR = 4,67 CI 95% = 1,51-14,45), pekerjaan responden (OR = 4,66, CI 95% =1,76 -12,31), kepatuhan minum obat profilaksis (OR = 7,91, CI 95% = 2,92-21,43). Kepatuhan minum obat profilaksis merupakan faktor risiko yang paling dominan untuk terjadinya penyakit filariasis (OR= 12,97 (95%CI = 3,35-50,15) setelah dikontrol variabel keberadaan resting place, pekerjaan, usia, dan ketinggian tempat tinggal (m). Faktor paling dominan terhadap kejadian filariasis adalah kepatuhan minum obat profilaksis setelah dikontrol keberadaan resting place, pekerjaan, usia dan ketinggian tempat tinggal (m).