bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical fitness assessment for lower limb disability: rationale and design to develop a new formula
Authors: Ernandini Endang , Trevino Aristarkus Pakasi  , Dewi Irawati Soeria Santoso  , Tinduh Damayanti , Listya Tresnanti Mirtha  , Sally Aman Nasution  , Anita  , Nusdwinuringtyas Nury 
Published: December 2022

Introduction: Injuries are a major medical problem in military populations. The physical fitness assessment is a series of tests that measure and monitor physical fitness levels. The existing physical fitness assessment and formula used by the Indonesian Military requires a running test that only applies to healthy soldiers. This study attempted to construct a formula for assessing physical fitness using tests that soldiers may perform with lower limb injury/disability.
Method: The design of the study was an internal cross-sectional comparison. This study included 104 healthy, well-trained male normal soldiers (NS) and 50 injured or disabled soldiers (DS) who matched the inclusion criteria. The NS was required to perform a 12-minute running and wheeling test, a ball-throwing test, push-ups, and lunges. The DS was also required to perform the same tests except for the 12-minute running test and lunges. The analysis of the data consisted of four steps: constructing a conceptual framework, describing the characteristics of each group, identifying significant indicators using Partial Least Square-Structural Equation Modeling (PLS-SEM) to develop a physical fitness formula, and determining whether the formula is appropriate for assessing physical fitness in running and wheeling tests.
Result: There is no significant difference in the characteristics of NS and DS (p>0.05); thus, the subjects in both groups are comparable. Physical fitness test has several major contributing factors: distance, test method, muscle strength, and age. There is no significant difference in the number of NS in each category between the running and wheeling tests (p>0.05).
Conclusion: Physical fitness formula= {1.1 × (0.98 × distance*) + (0.97 × method value**)} – (0.093 × age) – (0.17 × muscle strength***) Note: *) Distance traveled during running or wheeling test (meter). **) The running test method value is entered as 1, and the wheeling test method value is entered as 2. ***) The value of wheeling muscle strength is obtained from the ball-throwing test. In contrast, the value of running muscle strength can be determined by multiplying the result of the ball-throwing test by 2. These findings may be used for assessing the physical fitness of normal soldiers or those with lower limb injury/disability.
Comparative study of SOFA, WSESSSS, and CPIRO scoring systems as mortality predictors in a patient with complicated intra-abdominal infection
Authors: Nugraha Gigih Laksamana , Septarendra Denny , Lesmana Tomy 
Published: December 2022

Background: A widespread intra-abdominal organ infection or complicated intra-abdominal infection (cIAI) causes localized peritonitis, intra-abdominal abscess, and diffuse peritonitis. Patients suffer from morbidity and mortality as a result of this condition. Sepsis indicators such as SOFA, WSESSSS, and CPIRO scores were predictors of mortality in cIAI patients. We aimed to examine the performance of WSESSSS, CPIRO, and SOFA scoring systems to predict mortality in patients with cIAI.
Methods: A retrospective cohort, analytic observational study was conducted to assess differences in SOFA, WSESSSS, and CPIRO scoring systems' sensitivity, specificity, and accuracy as predictors of death during treatment in cIAI patients in Dr. Soetomo General Hospital, Surabaya.
Results: A total of 265 patients were evaluated. The optimal cutoff for SOFA was score 5 with sensitivity, specificity, PPV, NPV, and accuracy of 77.2%, 87.9%, 77.2%, 87.9%, and 84.2%, respectively. The optimal cutoff for WSESSSS was score 8 with sensitivity, specificity, PPV, NPV, and accuracy of 83.7%, 82.7%, 72.0%, 90.5%, and 83.0%, respectively. The optimal cutoff for CPIRO was 4 with sensitivity, specificity, PPV, NPV, and accuracy values of 62.0%, 90.2%, 77.0%, 81.7%, and 80.4%, respectively. Patients with high scores had a higher percentage of being hospitalized longer and cost higher than patients with a low score.
Conclusion: The SOFA, WSESSSS, and CPIRO scoring systems had comparable performance in predicting mortality in patients with cIAI. Considering the performance of WSESSSS, the use of WSESSSS alone may be sufficient enough to predict the outcome of patients with cIAI in Indonesia.
Granulocyte colony-stimulating factor therapy as a bridging treatment for pediatric decompensated liver cirrhosis prior to liver transplantation: an open-label randomized clinical trial
Authors: Rahayatri Tri Hening , Harahap Alida , Hendarto Aryono , Oswari Hanifah , Setiabudy Rianto , Taher Akmal 
Published: December 2022

Background: Decompensated cirrhosis (DC) in children is the main indication of liver transplantation (LT). The lack of access to liver transplantation and impending clinical complications while awaiting transplantation affect the morbidity and mortality in pretransplant patients. Granulocyte colony-stimulating factor (G-CSF) therapy has shown promising results in adult decompensated cirrhosis as a potential bridging treatment. Our study aimed to identify the effect of G-CSF on pediatric end-stage liver disease (PELD) score, liver function, CD34+ cell mobilization, nutritional status, survival, and short-term side effects in children awaiting LT.
Methods: This study was an open-label, randomized controlled trial that included patients with decompensated liver cirrhosis between 3 months and 12 years of age. The intervention group received 12 courses of G-CSF subcutaneous injection (5 μg/kg/day) plus standard medical treatment (SMT) for liver cirrhosis. Results were obtained regarding PELD scores, liver function, CD34+ cell mobilization, changes in leukocyte and neutrophil counts, nutritional status, survival, and side effects within three months.
Results: Thirty-five pediatric patients were randomized into the intervention (17 patients) and control (18 patients) groups. During the trial, 14 (82%) in the intervention group completed the treatment. The median ages of the patients in the intervention and control groups were 18 and 14.5 months, respectively. The study's primary outcome identified no statistically significant difference in PELD scores between the intervention and control groups after G-CSF treatment. Liver function tests that showed significant changes in the intervention group compared to the control group were from improvements in alanine aminotransferase (ALT) levels. Other liver function tests, nutritional status, and survival did not. CD34+ cell mobilization was increased in the intervention group compared with the control group, but there was no significant difference. Minor side effects of G-CSF were observed in the intervention group.
Conclusion: Multiple doses of G-CSF did not improve the PELD score, nutritional status, and survival after three months but significantly showed temporary improvement in ALT level.
Acceptance of the covid-19 vaccine based on health belief model
Authors: Eppy Setiyowati  , Rahayu Anggraeni  , Priyo Mukti Winoto  , Domingas da Silva Soares Pereira  , Paulo Lopes  , Aquino Tinos Martins  
Published: December 2022

Introduction: Cases of coronavirus that causes Covid-19 disease in the world have reached 1.8 million people. Cases of coronavirus that causes Covid-19 disease in the world have reached 1.8 million people. The purpose of the study analyzed predictions of covid-19 vaccine acceptance based on sufferers and health belief models in Indonesia and Timor Leste.
Method: Analytical research method with cross-sectional survey approach, the population is taken from community living at Surabaya Indonesia and Timor Leste as many as 250 respondents. Sampling was conducted in a consequent sampling in two regions at Surabaya Indonesia and Timor Leste. Data collection using google form, share through were respondents. Statistical analysis with rank spearmen.
Result: the relationship of vulnerability perception with acceptance vaccine covid-19 and correlation coefficient showing a figure of 0.29. It refers to the value of 0.20- 0.40 is considered weak. Similarly, the relationship of severity perception with acceptance vaccine covid-19 obtained coefficient correlation 0.41 expressed strong. on the perception of cues doing actions with acceptance vaccine covid-19, there is a strong relationship, because value correlation coefficient 0.41. For the relationship of benefit perception with acceptance vaccine covid-19 get a weak result because the correlation coefficient of 0.23 in the category below 0.40 is considered weak.
Conclusion: there are four components of Health Belief Model associated with Acceptance vaccine covid-19
The impact of COVID-19 on personal hygiene behavior of female students in islamic boarding school
Authors: Agustina Widayati  , Umi Narsih  , Homsiatur Rohmatin  
Published: December 2022

Introduction: Corona Virus Infection 2019 (Covid-19) is still a problem faced by all countries in the world, including Indonesia. Islamic boarding schools are a vulnerable place to be cluster spread of COVID-19 because there is much interactivity in a limited environment. This study aims to study the impact of Covid-19 on the personal hygiene behavior of female students in Islamic Boarding School.
Methods: The research design is cross-sectional. The sample in this study was 117. Data collection using questionnaires and interviews by applying strict health protocols. Data analysis used univariate and bivariate.
Results: The results of the study informed that before covid-19 there were many female students who did not practice personal hygiene properly. Meanwhile, during the COVID-19 pandemic, most of the female students had practiced personal hygiene with sufficient category. Conclusion: There was a significant change in the personal hygiene behavior of female students in Islamic boarding schools before and during the COVID-19 pandemic.
Comparison of sperm parameters and fertility rate in subclinical varicocele patients treated with varicocelectomy versus no varicocelectomy: a systematic review
Authors: Afdal  , Fakhri Zuhdian Nasher  
Published: December 2022

Introduction: Subclinical varicocele is defined as non-palpable varicocele which diagnosed solely through imaging examination, namely ultrasonography. Despite the current high prevalence of subclinical varicocele as one of the most common cause of men infertility, there is still lack of evidence regarding the need to perform varicocelectomy among these patients. This systematic review aims to evaluate and compare the sperm parameters and fertility rate of subclinical varicocele patients treated with varicocelectomy versus no treatment.
Methods: A systematic literature search was conducted on the international databases PubMed, Scopus, Cochrane, EMBASE, EBSCOHost, and Google Scholar published in the last ten years up to August 21st, 2022. Risk of bias assessment was performed using the Newcastle-Ottawa Scale tools for cohort study and converted regarding the AHRQ standards.
Results: Three cohort studies were conducted in three different countries with 363 patients. The risk of bias assessment revealed that all of the three studies included in this review have good quality and low risk of bias. Varicocelectomy significantly improves sperm parameters in terms of sperm concentration (p<0.05) and sperm motility (p<0.05) while its effects on sperm morphology are not significant (p>0.05). The effects of varicocelectomy on fertility rate are reported by one study by Cantoro et al. as significant (p=0.011).
Conclusion: Varicocelectomy correction has been proved to significantly improve sperm parameters in terms of sperm concentration and motility, while its effect on fertility rate remains unclear and no conclusion can be drawn yet. Therefore, this study recommends further randomized controlled studies with larger sample size in the future to prove the effectiveness of varicocelectomy in subclinical varicocele patients before its implementation in clinical settings.
Health literacy in patients undergoing hemodialysis: literature review
Authors: Rahmawati Berlian Ayu , Rochmawati Erna 
Published: December 2022

Patients with end-stage chronic kidney disease require hemodialysis treatment to maintain kidney function. The patients should be prepared to manage symptoms that may arise and cope with physical, psychological and financial changes. In addition, the patients are expected to be able to make their own decisions on how to manage the disease and adhere to treatment. This situation requires good health literacy skills. Little is known about the synthesis of health literacy among patients with chronic kidney disease.
Goal: To summarize the available evidence on benefits and factors that affect health literacy in patients undergoing hemodialysis from the available literature.
Method: The study reviewed health literacy among patients undergoing hemodialysis. A literature search using a database was conducted in Ebsco, PubMed, Science Direct, Scopus, and Emerald in December 2021 using the terms health literacy, hemodialysis, dialysis, CKD, and ESRD. We included studies from 2010-2021 that involved adult patients. Screening title, abstract, and full text were conducted to check each study's eligibility.
Results: A total number of eight of 1223 articles were included, with 2,036 respondents. Most included studies found that patients had a low level or inadequate health literacy (n = 5). In contrast, one study shows moderate health literacy (n = 2), and one article found a good level of health literacy. Higher health literacy was shown can improve patients' quality of life. The review summarizes several factors influencing health literacy, such as education, health care providers, life experiences, happiness and anxiety.
Conclusion: The review shows that most studies found lower health literacy levels. It is expected that nurses and healthcare professionals can improve health literacy which could positively impact patients' quality of life.
Carotid intima-media thickness in the first descendant of coronary artery disease patients with Apolipoprotein-E4 genotype
Authors: Prayogo Ahmad Rafi Satrio , Yunita Elvira , Yolanda Rachmawaddah , Fahri Ismir , Lestari Novriantika , Asteria Marisadonna , Nasution Ahmad Azmi , Jusup Endang  , Sipriyadi  , Djatmiko Ellen Maidia 
Published: December 2022

Introduction: Carotid intima-media thickness (CIMT) is a predictor marker of subclinical atherosclerosis that can be measured by ultrasound technique. The clinical symptoms of atherosclerosis usually begin with the thickening of the carotid artery walls. Polymorphism in Apolipoprotein E4 (APO-E4) is considered to be an important genetic determinant of atherosclerosis and Coronary Artery Disease (CAD). The genetic role of APO-E4 on plasma lipid has shown that the APO-E4 allele is associated with increased plasma LDL and total lipid concentration. The main objectives of this study were to identify genotype polymorphisms of the APO-E gene and measure the thickness of the carotid intima in subjects with APO-E4 polymorphisms in the first descendant of coronary heart patients.
Patients and methods: A cross-sectional study design was used to determine the polymorphism of the APO-E4 genotype in the first descendant of CAD and non-CAD groups. There were 21 samples in each group. Gene polymorphism examination was carried out by PCR and the CIMT was measured with doppler ultrasound.
Results: The result showed that 21.4% of subjects had polymorphism of the APO-E4 genotype with a significant difference between CHD and non-CHD group. This data shows that the APO-E4 genotype is more dominant in the first descendant of patients with CHD when compared to non-CHD parents. The mean values of CIMT ini right and left-sided carotid arteries among APO-E4 genotype and non-APO-E4 genotype were 0.4743 mm vs. 0.4195 mm and bivariate analysis showed a significant difference with a P-value of 0.017. This shows that there is a significant difference in the thickness of the carotid intima in the first descendant of subjects who have the APO-E4 genotype and those who do not.
Conclusion: The APO-E4 gene polymorphism was more dominant in the first descendant of CAD patients with a higher CIMT mean value.
Clinicopathological characteristics and possible risk factors for extrauterine metastases in endometrial carcinoma
Authors: Teuku Mirza Iskandar  , Very Great Eka Putra  , Ediwibowo Ambari  , Endy Cahyono  , Lubena  
Published: December 2022

Introduction: Extrauterine metastases often occur in patients with advanced stages of endometrial carcinoma. Retroperitoneal lymph nodes and pelvic lymph nodes are the most common metastatic sites for endometrial carcinoma, while distant metastases, including those to the lung, liver, and brain, are uncommon. This study compares the characteristics of endometrial carcinoma with or without extrauterine metastases and evaluates risk factors associated with extrauterine metastases.
Methods: A retrospective analytical study of 155 women with a history of endometrial cancer
following complete surgical staging treatment from January 2017 to December 2021 at Dr. Kariadi General Hospital Semarang. All data were obtained using medical records. The clinical and pathological characteristics were compared using the Unpaired T-test and Chi-Square test. Multivariate logistic models were performed to estimate the odds ratio (OR) and 95% CI to analyze independent risk factors for extrauterine metastases.
Results A total of 155 endometrial cancer patients were included in this study. Of these, 77 patients have extrauterine metastases (49.67%). The most common site for extrauterine metastases is ovarian metastases (26.5%). Using univariable and bivariate analysis, tumor differentiation grading (OR=3.69, p=0.027) and myometrial invasion (OR=2.84, p=0.027) were the two risk factors associated with extrauterine metastases.
Conclusion: There were significant differences in clinicopathological characteristics between the two groups with and without extrauterine metastases. Tumor differentiation grading and myometrial invasion were two independent risk factors.
Radiotherapy for primary angiosarcoma of the breast: a case report
Authors: Marlina Yoke Surpri , Novirianthy Rima , Yus Teuku Muhammad 
Published: December 2022

Background: Primary breast angiosarcomas are very rare type malignant breast tumor. It may have an insidious clinical onset, presenting as a painless, often discrete palpable mass that grows rapidly. The ranged age of disease is 20-50 years.
Case description: We report a case of a young woman with palpable and painless mass of her left breast. Based on radiological findings with mammography and MRI examination reported as malignant mass of the left breast suspected angiosarcoma. Pathological confirmation post-surgery reported a well-differentiated angiosarcoma that arose primarily in the left breast. Patient treated with simple mastectomy followed by whole breast radiotherapy. External beam radiotherapy delivered using 3DCRT with FIF technique, prescribed dose 60Gy in 30 fractions within 6 weeks.
Conclusion: There is no established standard treatment for primary angiosarcoma of the breast. Mastectomy remains the mainstay of treatment. Adjuvant radiotherapy appears to improve local control.
COMBINATION OF TEMPEH AND CARROT PREVENT ATHEROSCLEROSIS WISTAR RAT: Indicated by Increase of HDL and Total Antioxidant, Decrease LDL, F2-Isoprostan, and IL-6
Authors: Ari-Agung I G. A. , Suryadhi N. T. , Mantik N. A. , Suter I K. , Partama I. B. G. 
Published: December 2022

Coronary heart disease (CHD) is the leading cause of death, either in developed and developing countries. The disease is stimulated by the present of atherosclerosis. This study aims to investigate supplementation of combinedÂ tempehÂ M-2Â and carrot to prevent atherosclerosis wistar rat by increases HDL and TAC, decreases LDL, F2-Isoprostan, and IL-6.Â This was a true experimental study with the factorial completely randomized post-test only control group design. Â variables such as KN (standard feeding / pellets (50 g / kg bw / day), KP: pig lubrication: pellets (1: 9) (50 g / kg bw / day), T : lubrication pig: pellets (1: 9) with tempehÂ M -2Â (20 g / kg bw / day), W: pig lubrication: pellets (1: 9) with carrots (20 g / kg bw / day), and TW: pig lubrication: pellets (1: 9) with tempehÂ M-2Â (20 g / kg bw / day), and carrots (20 g / kg bw / day).Â Dependent variables in this study are serum HDL,serum TAC, LDL serum, urine F2-Isoprostan, and plasma IL-6 (with Elisa Method). Data were analyzed using the F test (two-way ANOVA), followed by LSD test. Descriptive research was also conducted in this study in order to find out the change of aortic histopathologic. The highest average levels of HDL, TAC contained on TW, which respectively amounted 68.640 Â± 0.50 mg / dl, 1.454 Â± 0.01 nM / mL. It showed highly significant differences (p<0.01) in the various treatments.Â TW treatment showed highly significant interaction effect (p<0.01) were observed for all parameters except for HDL. Average levels of LDL, F2- Isoprostan, and IL-6 Â lowest in the treatment TW, which respectively amounted Â 20.718 Â± 1.33 mg / dl, 0.720 Â± 0.065 ng / dl, 35.328 Â± 1.000 pg/dl, showed highly significant differences (p<0.01) in the various treatments. It can be concluded that supplementation with a combination of tempehÂ M-2Â with carrots give the best effect, can increases HDL and TAC, and can decreases LDL, F2-Isoprostan, IL-6 significantly, and may change the hystopathologyÂ structure of aorta from endotel dysfunction to become normal.