bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microfluidic In-Situ Spectrophotometric Approaches to Tackle Actinides Analysis in Multiple Oxidation States
Authors: Mattio Elodie , Caleyron Audrey , Miguirditchian Manuel , Lines Amanda M. , Bryan Samuel A. , Lackey Hope E. , Rodriguez-Ruiz Isaac , Lamadie Fabrice 
Published: February 2022

The study and development of present and future processes for the treatment/recycling of spent nuclear fuels require many steps, from design in the laboratory to setting up on an industrial scale. In all of these steps, analysis and instrumentation are key points. For scientific reasons (small-scale studies, control of phenomena, etc.) but also with regard to minimizing costs, risks, and waste, such developments are increasingly carried out on milli- or microfluidic devices. The logic is the same for the chemical analyses associated with their follow-up and interpretation. Due to this, over the last few years, opto–microfluidic analysis devices adapted to the monitoring of different processes (dissolution, liquid–liquid extraction, precipitation, etc.) have been increasingly designed and developed. In this work, we prove that photonic lab-on-a-chip (PhLoC) technology is fully suitable for all actinides concentration monitoring along the plutonium uranium refining extraction (plutonium, uranium, reduction, extraction, or Purex) process. Several PhLoC microfluidic platforms were specifically designed and used in different nuclear research and development (R&D) laboratories, to tackle actinides analysis in multiple oxidation states even in mixtures. The detection limits reached (tens of µmol·L−1) are fully compliant with on-line process monitoring, whereas a range of analyzable concentrations of three orders of magnitude can be covered with less than 150 µL of analyte. Finally, this work confirms the possibility and the potential of coupling Raman and ultraviolet–visible (UV–Vis) spectroscopies at the microfluidic scale, opening the perspective of measuring very complex mixtures.
Measuring red tape in a hospital setting: A survey experiment
Authors: Luyten Janis , Marneffe Wim 
Published: February 2022

Public administration research is actively exploring alternatives for the General Red Tape (GRT) scale to measure red tape. Owing to increasing criticism on the GRT scale, scholars proposed the Three-Item Red Tape (TIRT) scale as an alternative. Using a repeated cross-sectional design, this article tests both scales in a before–after analysis of a major change in the organization of administration in a hospital. The results indicate that the GRT scale does not capture the resulting major change in red tape, which raises questions on the instrument's validity in a bottom-up research design within one organization. The TIRT scale, however, which measures red tape at the work environment level, does reflect the change in red tape but shows empirical weaknesses in its design. Additionally, by randomly assigning respondents to substantially different red tape definitions, this article shows that the red tape definition does not significantly impact respondents’ GRT ratings. Points for practitioners The predominantly used GRT scale is not able to capture an increase in red tape in a bottom-up intraorganizational research design in a hospital, which raises questions on the instrument's validity. A more recent alternative for the GRT scale, more specifically the TIRT scale, captures the increase in red tape but shows empirical weaknesses. The wording of the red tape definition does not impact respondents’ answers on the GRT scale.
LSD and creativity: Increased novelty and symbolic thinking, decreased utility and convergent thinking
Authors: Wießner Isabel , Falchi Marcelo , Maia Lucas Oliveira , Daldegan-Bueno Dimitri , Palhano-Fontes Fernanda , Mason Natasha L , Ramaekers Johannes G , Gross Madeleine E , Schooler Jonathan W , Feilding Amanda , Ribeiro Sidarta , Araujo Draulio B , Tófoli Luís Fernando 
Published: February 2022

Background: Controversy surrounds psychedelics and their potential to boost creativity. To date, psychedelic studies lack a uniform conceptualization of creativity and methodologically rigorous designs. Aims: This study aimed at addressing previous issues by examining the effects of lysergic acid diethylamide (LSD) on creativity using multimodal tasks and multidimensional approaches. Methods: In a randomized, double-blind, placebo-controlled, crossover study, 24 healthy volunteers received 50 μg of LSD or inactive placebo. Near drug peak, a creativity task battery was applied, including pattern meaning task (PMT), alternate uses task (AUT), picture concept task (PCT), creative metaphors task (MET) and figural creativity task (FIG). Creativity was assessed by scoring creativity criteria (novelty, utility, surprise), calculating divergent thinking (fluency, originality, flexibility, elaboration) and convergent thinking, computing semantic distances (semantic spread, semantic steps) and searching for data-driven special features. Results: LSD, compared to placebo, changed several creativity measurements pointing to three overall LSD-induced phenomena: (1) ‘pattern break’, reflected by increased novelty, surprise, originality and semantic distances; (2) decreased ‘organization’, reflected by decreased utility, convergent thinking and, marginally, elaboration; and (3) ‘meaning’, reflected by increased symbolic thinking and ambiguity in the data-driven results. Conclusion: LSD changed creativity across modalities and measurement approaches. Three phenomena of pattern break, disorganization and meaning seemed to fundamentally influence creative cognition and behaviour pointing to a shift of cognitive resources ‘away from normal’ and ‘towards the new’. LSD-induced symbolic thinking might provide a tool to support treatment efficiency in psychedelic-assisted therapy.
Superior Outcome of Early ACL Reconstruction versus Initial Non-reconstructive Treatment With Late Crossover to Surgery: A Study From the Swedish National Knee Ligament Registry
Authors: Bergerson Emma , Persson Kajsa , Svantesson Eleonor , Horvath Alexandra , Olsson Wållgren Jonas , Karlsson Jon , Musahl Volker , Samuelsson Kristian , Hamrin Senorski Eric 
Published: February 2022

Background: Although comparable clinical and functional outcomes have been reported after nonsurgical and surgical anterior cruciate ligament (ACL) treatment, few studies have investigated the effects of early versus late ACL reconstruction with initial rehabilitation. Purpose: To determine patient-reported knee function in patients who initially undergo nonreconstructive treatment after an ACL injury but who later choose to undergo ACL reconstruction as compared with (1) patients undergoing ACL reconstruction close to the index injury and (2) patients treated nonreconstructively at 1 to 10 years of follow-up. Study Design: Cohort study; Level of evidence, 2. Methods: Results from the Knee injury and Osteoarthritis Outcome Score (KOOS) were extracted from the Swedish National Knee Ligament Registry for patients treated with nonreconstruction, early ACL reconstruction, and initial nonreconstruction but subsequent ACL reconstruction (crossover group). The KOOS4 (a mean of 4 KOOS subscales) was analyzed cross-sectionally at baseline and at the 1-, 2-, 5-, and 10-year follow-ups. Additionally, the Patient Acceptable Symptom State (PASS) was applied to all KOOS subscales from baseline to the 10-year follow-up. Results: A total of 1,074 crossover, 484 nonreconstruction, and 20,352 early ACL reconstruction cases were included. The crossover group reported lower KOOS4 values than the group undergoing early ACL reconstruction at baseline and at all follow-ups (mean difference [95% CI]): baseline, −6.5 (−8.0 to −5.0); 1 year, −9.3 (−10.9 to −7.7); 2 years, −4.8 (−6.3 to −3.2); 5 years, −6.1 (−8.8 to −3.4); and 10 years, −10.9 (−16.3 to −5.2). Additionally, a smaller proportion of the crossover cohort achieved a PASS on KOOS subscales at baseline and through the 1-, 2-, 5-, and 10-year follow-ups as compared with the early ACL reconstruction cohort. No differences were observed between crossover and nonreconstruction cases on either the KOOS4 or the PASS at any follow-up. Conclusion: A greater proportion of patients treated with early ACL reconstruction reported acceptable knee function and superior overall knee function as compared with patients who decided to cross over from nonreconstructive treatment to ACL reconstruction.
Increased Elbow and Olecranon Injury History in Professional Pitchers With Increased Elbow Flexion at Ball Release
Authors: Manzi Joseph E. , Ciccotti Michael C. , Trauger Nicolas , Black Grant G. , Thacher Ryan R. , Boddapati Venkat , Dines Joshua S. 
Published: February 2022

Background: Elbow flexion at late portions of the pitch has been associated with increased elbow varus torque, a kinetic surrogate associated with injury risk. Direct examinations of injury incidence with elbow flexion angles have not been conducted in professional pitchers. Purpose: To compare elbow and shoulder injury incidence among professional baseball players stratified by degree of elbow flexion at ball release (BR). Study Design: Descriptive laboratory study. Methods: Professional pitchers (N = 314) were instructed to pitch between 8 and 12 fastballs while being evaluated using motion capture technology. Upper extremity injury incidence was recorded upon interview. Pitchers were subsequently subdivided into 3 groups based on increasing elbow flexion at BR. Analysis of variance was used to compare participant characteristics and kinematic and peak kinetic variables. An odds ratio (OR) was calculated to determine the risk of having a previous upper extremity injury based on the degree of elbow flexion at BR. Results: A total of 116 pitchers (132 documented injuries) had a previous upper extremity injury, with elbow injury (76 injuries; 57.6%) being the most common. Evaluation of kinetic values showed that pitchers with the smallest elbow flexion at BR had significantly less peak elbow flexion torque than did those with greatest elbow flexion at BR (3.8 ± 0.5 vs 4.1 ± 0.6 %weight × height; P = .003). Pitchers who demonstrated a greater than average degree of elbow flexion at BR when pitching were more likely to have a history of elbow injury (OR, 1.97; 95% CI, 1.14-3.40; P = .015) and olecranon spur formation or stress fracture (OR, 5.79; 95% CI, 1.25-26.85; P = .025). Conclusion: Pitchers with greater elbow flexion at BR had significantly higher odds of previous injury of the elbow and olecranon. Increasing elbow flexion has been shown to place the medial elbow in a position to carry a greater amount of load, which may be exacerbated during the final moments of the pitching motion. Professional pitchers can consider decreasing elbow flexion at BR as a potential, modifiable risk factor for elbow injury, in particular for olecranon spur formation and fracture. Clinical Relevance: This study attempts to associate injury incidence with a modifiable, kinematic variable for an at-risk population.
The physical exam’s role in determining dose-limiting toxicity prior to immunochemotherapy administration in lymphoma
Authors: Runge John S. , Brown Anna B. , Phillips Tycel J. , Kaminski Mark S. , Carty Shannon A. , Wilcox Ryan A. 
Published: February 2022

Introduction The COVID-19 pandemic has introduced new challenges to healthcare access and delivery. It is critical to identify areas for innovation within oncologic clinical practice to maintain high quality care. We evaluated the potential utility of telemedicine initiatives for patients with lymphoma undergoing immunochemotherapy. We conducted a retrospective review of adult lymphoma patients receiving R-CHOP  +  /- R, R-ICE, R-GEMOX, and R-DHAP at our institution in the last three years (2017-2019) and identified cycles for which dose modifications were required. Methods We reviewed 1290 total treatment cycles in 301 unique patients, 1102 cycles (85.4%) were R-CHOP  +  /- R, 105 (8.1%) were R-ICE, 71 (5.5%) were R-GEMOX, and 12 (0.9%) were R-DHAP. We identified that 144 cycles (11.2%) were subject to dosing adjustments. We retrospectively reviewed laboratory results, patient history, and/or physical exam findings that informed dose modifications. Results Of the 144 dose adjustments, 11% of cycles contained dose increases due to a well-tolerated previous dose noted in the clinical assessment. The remaining 128 modified cycles were dose reductions. Notably, only 7/128 dose reductions were based on physical exam findings alone, due solely to a change in patient body weight. As patients are routinely weighed immediately prior to chemotherapy administration, effectively no dose modifications (0/144) were exclusively based on abnormal physical exam finding during a pre-infusion assessment. Conclusion These findings suggest that pre-infusion assessments may be amenable to virtual visits for lymphoma patients undergoing immunochemotherapy.
Cost-effectiveness of telehealth-delivered diet and exercise interventions: A systematic review
Authors: Law Lynette , Kelly Jaimon T , Savill Holly , Wallen Matthew P , Hickman Ingrid J , Erku Daniel , Mayr Hannah L 
Published: February 2022

Objectives Telehealth is a promising tool for delivering lifestyle interventions for the management of health conditions. However, limited evidence exists regarding the cost-effectiveness of these interventions. This systematic review aimed to evaluate the current literature reporting on the cost-effectiveness of telehealth-delivered diet and/or exercise interventions. Methods Four electronic databases (PubMed, CENTRAL, CINAHL and Embase) were searched for published literature from database inception to November 2020. This review adhered to the preferred reporting items for systematic reviews and meta-analyses guidelines and the ISPOR Criteria for Cost-Effectiveness Review Outcomes Checklist. The quality of reporting was assessed using the Consolidated Health Economic Evaluation Reporting Standards checklist. The extracted data were grouped into subcategories according to telehealth modality, organised into tables and reported narratively. Results Twenty-four studies of controlled trials (11 combined diet and exercise, 9 exercise-only and 4 diet-only telehealth-delivered interventions) were included for data extraction and quality assessment. Interventions were reported as cost-effective in 12 studies (50%), five studies (21%) reported inconclusive results, and seven studies (29%) reported that the interventions were not cost-effective. Telephone interventions were applied in eight studies (33%), seven studies (29%) used internet interventions, six studies (25%) used a combination of internet and telephone interventions, and three studies (13%) evaluated mHealth interventions. Quality of study reporting varied with between 54% and 92% of Consolidated Health Economic Evaluation Reporting Standards items reported. Conclusions This review suggests that telehealth-delivered lifestyle interventions can be cost-effective compared to traditional care. There is a need for further investigations that employ rigorous methodology and economic reporting, including appropriate decision analytical models and longer timeframes.
Polypyrrole-coated recycled polyphenylene sulfite nonwoven fabric with high electrical conductivity for heat generation
Authors: Lu Zhenqian , Lv Jingchun , Qiu Jiawen , Zhang Linsheng 
Published: February 2022

In order to introduce multifunctional properties into the recycled polyphenylene sulfite (PPS) nonwoven fabrics, highly conductive and hydrophobic fabrics with excellent Joule heating performance were fabricated by depositing in-situ polymerized polypyrrole (PPy) onto PPS nonwoven fabric and followed by a silicone coating process. The resultant PPy-coated nonwoven fabric exhibited high electrical conductivity. The surface resistivity of PPy-coated nonwoven fabric was less than 8.8 Ω/sq. The high conductivity of PPy coating provided the fabric with excellent electrical heating properties in conjunction with a photothermal heating properties. The saturation temperature of the samples can get to 125.6°C with 4V DC power. The thin silicone coating can help to resist the oxidation of PPy and endow the nonwoven fabrics with excellent water-resistant features. This study provided a simple and effective method to transform the recycled PPS nonwoven fabric into a multifunction material.
Thirty-day morbidity and mortality following primary total elbow arthroplasty in octogenarians
Authors: Gupta Puneet , Quan Theodore , Manzi Joseph E. , Zimmer Zachary R. 
Published: February 2022

Background Octogenarians are at an increased risk of morbidity and mortality following various orthopaedic procedures, but this has not been explored among total elbow arthroplasty (TEA) patients. Thus, this study analyzed whether octogenarians undergoing TEA are at an increased risk of postoperative complications relative to the younger geriatric population. Methods A national database was queried to identify TEA patients. Patients were stratified into an aged 65 to 79 cohort and an aged 80 to 89 cohort. Demographics, comorbidities, and complications were assessed, with the use of bivariate and multivariate analyzes. Results In total, 390 patients underwent TEA, with 289 (74.1%) between the ages of 65 to 79 and 101 (25.9%) between the ages of 80 to 89. On bivariate analyzes, patients aged 80 to 89 were more likely to undergo postoperative transfusion ( p = 0.001) compared to those aged 65 to 79. Following adjustment on multivariate analyzes, the aged 80 to 89 cohort no longer had an increased risk of postoperative transfusion. There were no differences in mortality, readmission, and reoperation between the two groups. Discussion Age greater than 80 should not be used as an independent factor when evaluating whether a geriatric patient is an appropriate candidate for TEA.
Presence And Temporal Activities Of Serrated Hinged Terrapin (Pelusios sinuatus) And Marsh Terrapin (Pelomedusa galeata) In KwaZulu-Natal, South Africa, Assessed Using Telemetry
Authors: Price Cormac , Burnett Matthew J , O’Brien Gordon , Downs Colleen T 
Published: February 2022

Background and Aims For the first time in Africa, two freshwater turtle species (hereafter terrapin) presence and temporal activity in their habitats were investigated using radio telemetry. Methods Telemeter tags were attached to Pelusios sinuatus ( n = 10) at Ndumo Reserve and Pelomedusa galeata ( n = 10) at Tala Reserve. Pelusios sinuatus tagged individuals were monitored between August–December 2016 at Ndumo, while P. galeata individuals were monitored between November 2017–July 2018 at Tala. Sensors on the tag determined the tag temperature and temporal activity. We examined both species' frequency distributions of inactivity to time of day. Activity trends for both species in comparison with ambient temperature and tag temperature were analyzed. Results Tags showed individuals presence or absence as detected by fixed remote networks at the study sites. Tagged P. sinuatus in Ndumo disappeared after a flood without returning after the flood receded. Both species were diurnal, with P. galeata showing a greater ability to maintain tag temperature above ambient temperature in the first 10 h of a day than P. sinuatus. Climatic data, including ambient temperature, rainfall, and wind, were retrieved from weather stations. The most significant climatic variable that affected activity was ambient temperature. Rainfall also showed a significant effect, but wind showed no significant effect. Implications for Conservation This method can become a valuable tool for long-term remote monitoring of other semi-aquatic reptiles in wetlands that are increasingly under anthropogenic and climatic pressure. Thus, its implications for conservation are significant.
Complicated Facial Lacerations: Challenges in the Repair and Management of Complications by a Facial Trauma Team
Authors: De Moumita , Sagar Sushma , Dave Aniket , Kaul Ruchi Pathak , Singhal Maneesh 
Published: February 2022

Study Design: This is a descriptive study where we present our experience in managing complicated facial wounds over a period of 1 year at a level 1 trauma centre by a dedicated facial trauma team consisting of a plastic surgeon, a trauma surgeon and a Maxillofacial surgeon. Objective: Facial deformities have profound impact on the social and psychological aspect of a person’s life. Hence, management of facial wounds is very crucial. Most of the facial injuries are usually managed by emergency care physician and emergency surgeon. But certain wounds require specialised knowledge and care due to their complicated nature. The objective of this paper is to highlight those special types of wounds and the challenges they pose. It also aims to enumerate the best possible management according to each situation in a protocol-based manner, which will help in decision making by the attending emergency physician/surgeon. Methods: Facial lacerations were designated as “complicated” according to some pre-defined features and pre, intra and post operative data and photographs were collected by interviewing the concerned surgical team. The data were analysed and presented as different clinical scenarios. Results: The cases were broadly grouped under 6 scenarios according to the unique combination of difficulties faced and their specific management. The challenges faced were enumerated and the steps undertaken were also mentioned against them. Lastly, the scenarios were compared with available literature to find out the best possible management in each situation and to present them in a protocol-based manner. Conclusion: Protocol-based management of injuries to the different parts and specialised structures of the face is extremely helpful. Role of a specialised facial trauma team also should be emphasised in complicated facial injuries.
Effects of non-invasive brain stimulation in multiple sclerosis: systematic review and meta-analysis
Authors: Kan Rebecca L.D. , Xu Grace X.J. , Shu Kate T. , Lai Frank H.Y. , Kranz Gottfried , Kranz Georg S. 
Published: February 2022

Objective: The objective of this meta-analysis was to summarize evidence on the therapeutic effects of non-invasive brain stimulation (NIBS) on core symptoms of multiple sclerosis (MS). Specifically, findings from studies deploying transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) protocols were summarized in this review. Methods: We systematically searched articles published in four databases, until 31 May 2021, which compared the effects of active tDCS or rTMS with sham intervention in MS patients. We used a random-effects model for this meta-analysis. Meta-regression and subgroup meta-analysis were used to examine the effects of stimulation dose and different stimulation protocols, respectively. Results: Twenty-five randomized controlled trials (RCTs) were included in this review, consisting of 19 tDCS and 6 rTMS studies. tDCS led to a significant and immediate reduction of fatigue with a large effect size (Hedges’s g = −0.870, 95% confidence intervals (CI) = [−1.225 to −0.458], number needed to treat (NNT) = 2). Particularly, a subgroup analysis showed that applying tDCS over the left DLPFC and bilateral S1 led to fatigue reductions compared to sham stimulation. Furthermore, tDCS had favorable effects on fatigue in MS patients with low physical disability but not those with high physical disability, and additionally improved cognitive function. Finally, whereas rTMS was observed to reduce muscle spasticity, these NIBS protocols showed no further effect on MS-associated pain and mood symptoms. Conclusion: tDCS in MS alleviates fatigue and improves cognitive function whereas rTMS reduces muscle spasticity. More high-quality studies are needed to substantiate the therapeutic effects of different NIBS protocols in MS.