bluuebunny/crossref_metadata_2025_split huggingface dataset:
Berberine reduces enteroglial-derived S100B production to alleviate gut vascular barrier damage
Authors: Feng Aiwen , He Yan , Kang Yutian , Ma Minghui , Qiu Jiasheng , Zhou Jun 
Published: August 2022

Abstract
Gut vascular barrier (GVB) controls the systemic dissemination of bacteria. Enteric glial cells (EGCs) in mucosa as a component of gut vascular unit can amplify inflammation via S100B. Berberine (BBR) is an alkaloid that can alleviate gut inflammation and regulate EGCs activity. In this study, we aimed to unravel the mechanism by which BBR inhibited EGCs-derived S100B generation to protect GVB. In vivo BBR was given via oral gavage to mice who were subjected to 40% total body surface area burns. In vitro BBR, S100B and caspase-8 inhibitor Z-IETD-FMK were used to treat mouse intestinal microvascular endothelial cells (MIMECs). The results showed that (1) BBR lowered serum S100B concentration and decreased S100B accumulation in colonic mucosa; (2) BBR and S100B monoclonal antibody (S100BmAb) lowered burn-induced GVB hyperpermeability; (3) BBR antagonized the effect of S100B enema on GVB permeability; (4) S100B and Z-IETD-FMK increased the permeability of MIMECs and reduced the expression of caspase-8, β-catenin, occludin and VE-cadherin in MIMECs, while these effects of S100B were effectively antagonized by BBR treatment; (5) Z-IETD-FMK inhibited β-catenin expression in MIMECs. Collectively, our findings showed that S100B accumulation in gut mucosa damaged GVB, and BBR treatment alleviated GVB damage via modulation of caspase-8/β-catenin signaling pathways.
Novel Formulation and Evaluation of Poly Herbal Mosquito Repellent
Authors: GUPTA DEEPAK KUMAR , Gupta Revathi , Tiwari Akhilesh 
Published: August 2022

Abstract
Aromatic plants produce chemicals that they use to resist phytophagous attacks Mosquito with various pathways, such as repellents, protective eating, metabolites and development Controllers etc. Now, present-day conditions result in the burgeoning need for natural mosquito repellents that would have cheap, reliable, non-toxic, environmentally safe, and biodegradable attributes. Driven by the global need to move forward, mosquito repellent candle and Mosquito repellent gel formulation based on carbopol 934 was prepared from the Origanum Majorana, Tanacetum Cinerarifolium, Juniperus Communis, Scented Geranium, Thuja Occidentalis L., Tecoma Stans (L.), Artenmisia Arborescent, And Calamintha Acinos and They are further tested for their size, pH, viscosity, spread ability, extrudability, swelling index and accelerated tests. The prepared candle was tested for flammability and was burnt Performance with respect to burning time and consequently its efficacy Spotting operation. Candle in flammability check was performed to Checks its consistent laboratory combustibility. Basic Therefore, on performance, the time taken to light the candle and its Causal symptoms such as pain, coughing has been reported and recorded in identified mosquitoes vulnerable at night and in the field above. Throughout many developed countries, where most residents have little exposure to mosquito net, high-cost mosquito repellent creams, and miscellaneous physical approaches, this formulation of gel may be an efficient, affordable, and easily accessible way to deter mosquito-borne diseases such as malaria, dengue, etc. in the lower parts of society.
Research on thermal error modeling of CNC milling head for five-axis machine tools based on GA-ACO optimized BP neural network
Authors: Dai Ye , Li Yang , Zhan Shiqiang , Li Zhaolong , Jiang Yupeng , Mao Xintao 
Published: August 2022

Abstract
The predictive performance of the thermal error model determines real-time compensation effect of the Computer Numerical Control (CNC) milling head, and the identification of temperature-sensitive points directly affects the robustness of the modeling. Therefore, a genetic algorithm and ant colony algorithm optimization based BP neural network (GA-ACO-BPNN) model is proposed to improve the generalization and robustness of the thermal error prediction model. This research Takes the 5AS milling head as the research object, the thermal characteristics are analyzed to determine its temperature field distribution. The K-means + + algorithm and gray correlation analysis are used to reduce 11 temperature measurement points to 4, which improves the input quality of the model. Combined with GA and ACO to search for optimal parameters of the BP network, it overcomes the problems of slow convergence speed and quickly falls into local extremes. Compared with the radial basis function neural network (RBFNN) model and ACO-BPNN model, the average value of Root Mean Square Error (RMSE) of the Z-directional thermal errors predicted by the GA-ACO-BPNN model is reduced by 45.3% and 58.3%; and the average value of Mean Absolute Error (MAE) is decreased by 65.2% and 53.8%, respectively.
Is the supine position suitable for ultrasound-guided percutaneous nephrolithotomy in patients with complex renal stones?
Authors: Xiao Bo , Zeng Xue , Zhang Gang , Ji Chaoyue , Jin Song , Bai Wenjie , Tang Yuzhe , Wang Bixiao , Li Jianxing 
Published: August 2022

AbstractIntroductionTo assess the safety and efficacy of ultrasound (US)-guided percutaneous nephrolithotomy (PCNL) for complex renal stones when performed in a modified supine position.MethodsWe retrospectively reviewed the charts of patients who underwent PCNL for complex renal stones at our institution between August 2018 and December 2021. During this time, 188 consecutive patients underwent US-guided PCNL in the prone position (P group, n=129) or in the flank-free modified supine position (S group, n=59). Patient demographics and intraoperative and postoperative data were analyzed.ResultsSuccessful renal access was achieved in all patients. The baseline demographics were comparable between the two groups. The numbers of renal access was significantly higher (2.1±0.4 vs 1.2±0.2, p=0.002) and the operation time was comparable (79.1±14.6 minutes vs 96.2±19.6 minutes, p=0.06) between the two groups. The postoperative hospital stay was also shorter in the P group (6.2±1.5 d vs 10.2±1.7 d, p=0.008). The postoperative hemoglobin loss was similar between the P and S groups (1.7±0.4 g/dl vs 1.8±0.3 g/dl, p=0.12). The stone-free rate (SFR) was significantly lower in the S group (57.5% vs 82.7%, p<0.001). There were no embolization or septic complications. Twelve patients (20.3%) in the S group underwent simultaneous or staged retrograde flexible ureteroscopy to remove residual stones.ConclusionUS-guided PCNL in the modified supine position was a safe treatment for complex renal stones. However, the single-session stone clearance rate was not ideal. The supine flank-free position may be unsuitable for US-guided PCNL in patients with complex renal stones.
The Effect of War on Expaned Program on Immunization in North East Ethiopia, 2022
Authors: Mezen Muluemebet Kassa , Lemlem Getasew Assefa , Biru Yemisrach Belete , Yimer Abebaw Mengesha 
Published: August 2022

Abstract
Background
Population affected by war experience severe public health consequences like displacement, food scarcity, collapse of infrastructure and basic health services. Furthermore, war greatly hinders health programs to be implemented by governmental and non-governmental organizations. One of the programs which face great challenge is the expanded program of immunization which has become crucial due to the emergence of different communicable diseases.
Objective
To assess the dropout rate of immunization after the war, identify associated factors for the dropout and explore the reasons behind for the dropout among under two children in North Wollo zone, Northeast Ethiopia 2022.
Method
A cross-sectional study mixed with phenomenological study design was utilized and the study was conducted in North Wollo zone, Northeast Ethiopia from April to June 2022.
Results
A total of 449 mothers with their children were included in the final analysis which made a response rate of 97%. Only half (50.3%) of the mothers heard about catch-up vaccine. Lost family member due to the war triples the risk of drop out of immunization (AOR: 3.11, 95%CI: 1.63, 5.93) and mothers who never heard about catch-up vaccine are two times more likely to drop out of immunization (AOR: 2.18, 95% CI: 1.39, 3.43).
Conclusions
The dropout rate from immunization is above the WHO cut point. Place of childbirth, hearing about catch-up vaccine, residence, length of the war in the area, and loss of family member due to war were predictors of drop out of immunization.
Investigating the Strength Recovery of Additively Manufactured Components Repaired Utilizing a 3D Printing Pen
Authors: Koren Kyle , Olajoyegbe Toluwalase , Kames Elisabeth , Morkos Beshoy W , Gutierrez Hector 
Published: August 2022

Abstract
The adoption of additive manufacturing methods is becoming prevalent in industry as they continue to increase intelligent technology automation [1] . However, this increase in unique service components will warrant the need for more flexible repair methods. This is particularly important for components that are difficult to access or disassemble – thus requiring an on-site or on-assembly repair. This paper introduces the use of 3D printing pens as a means to perform repair to additively manufactured components. A study was conducted to assess the feasibility of using a 3D printing pen in maintenance, repair and overhaul applications on polymer-based service products. A series of tensile tests were conducted on printed specimens, pre- and post-repair, to examine the tensile retention of the mended region. Results indicate significant retention in tensile strength in the mended specimens, supporting the notion of the pen’s relevance in repair and overhaul applications. Specimens that fractured within the repair region were seen to have retained (81 ± 10) % of their original tensile strength while specimens that fractured outside the region retained (86 ± 4) %. Considering the limited control of the study, results acquired encourage further analysis of the underlying mechanisms in the process, with the intent to exploit this approach more efficiently for practical structure-based repair applications.
Design of four-element MIMO antenna system for intelligent internet of everything (IIoE)
Authors: DKIOUAK Aziz , OUAHABI Mohssine EL , ZAKRITI Alia , CHAKKOR Saad , BAGHOURI Mostafa 
Published: August 2022

Abstract
In this paper, the design of four-element Multiple Input Multiple Output (MIMO) antenna system has been proposed for intelligent internet of Everything (IIoE) and high-speed data applications. The presented antenna design operates at 4.9 GHz (5G millimeter wave applications) with high isolation in a small size. Defected Microstrip Structure (DMS), slot modification and orthogonal polarization are used to create the desired frequency band, improve the impedance bandwidth and enhance the isolation between the antenna elements at 4.9 GHz, respectively. Furthermore, the usefulness of the proposed MIMO antenna has been verified by comparing the simulated and the measured results using a fabricated version of the considered 4x4 MIMO antenna. In addition, the results indicate a high diversity performance in terms of: Envelope Correlation Coefficient (ECC), Diversity Gain (DG), Total Active Reflection Coefficient (TARC) and Total Channel Capacity Loss (CCLTotal).
Essential oils as natural biocide against common brown- and white-rot fungi in degradation of wood products: antifungal activity evaluation by in vitro and FTIR analysis
Authors: Vettraino Anna Maria , Zikeli Florian , Humar Miha , Biscontri Margherita , Bergamasco Sara , Romagnoli Manuela 
Published: August 2022

Abstract
Use of wood products in bio-building is increasing because of the raw material´s sustainability and renewability. Degradation of wood by fungi is one of the most significant threats in the use of wooden structures. In the past, degradation was prevented by the application of wood preservatives or the use of durable tropical species. Therefore, wood preservation by fossil-based compounds and heavy metals is one of the major issues. This study evaluated the antifungal activity of four essential oils of thyme species (Thymus capitatus, Coridothymus capitatus, T. vulgaris and T. vulgaris Demeter) against two white-rot fungi (Trametes versicolor and Pleurotus ostreatus) and two brown-rot fungi (Poria monticola and Gloeophyllum trabeum). The thyme varietieséssential oils differed in their chemical composition, with either carvacrol, thymol or p-cymene as major components. All four essential oils showed good antifungal activities, in which T. capitatus was the most toxic when applied against P. monticola (MIC of 0.05) and the most efficient inhibiting the growth of the other fungal strains. Fourier transform infrared (FTIR) spectroscopy was applied to investigate fungal cell wall structure under control and stress conditions. The results are a further step towards more eco-friendly solutions for preserving less durable wood products more frequently used in bio-building.
PGC-1α affects Epileptic Seizures by regulating Mitochondrial Fusion in Epileptic Rats
Authors: Li Dongxu , Zhang Linhang , Zhang Fan , Tai Zhenzhen , Liu Xiping , Qiu Xiaowei , Zhang Haiqing , Yang Juan , Wang Jing , Luo Zhong , Xu Zucai 
Published: August 2022

Abstract
Background
Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), regulated by AMPK, is an important regulator of mitochondrial fusion. At present, whether the AMPK/PGC-1α signaling pathway regulates mitochondrial dynamics in epileptic rats is still unknown.
Methods
Adult male Sprague-Dawley (SD) rats were randomly divided into five groups: the control group (0.9% saline, n = 5), the EP groups (lithium-pilocarpine was used to induce epilepsy, and tissues were harvested at 6 and 24 h, every time point n = 5), the EP + Compound C group (the specific inhibitor of PGC-1α, 15 mg/kg in 2% DMSO, n = 5), and the EP + DMSO group (0.9% saline + 2% DMSO, n = 5). To observe the seizure susceptibility of the rats to epilepsy by behavioral study. MFN1, MFN2, and PGC-1α were measured using the Western blot and the immunofluorescence analysis.
Results
In this study, the behavioral results indicate that the seizure susceptibility of the rats to epilepsy was increased when the expression of PGC-1α was inhibited. Subsequently, Western blot results suggested that the expression level of both MFN1 and MFN2 in the hippocampus was higher at 6 and 24 h after an epileptic seizure. Besides, the expression of PGC-1α and MFN2 was significantly decreased in the hippocampus when the epileptic rats were treated with Compound C. Furthermore, the immunofluorescence analysis of the localization of MFN1/2 and PGC-1α showed that MFN1/2 was mainly expressed in neurons but not astrocytes in the hippocampus and cerebral cortex of rats. Meanwhile, PGC-1α colocalized with the excitatory post-synaptic marker PSD95, suggesting that PGC-1α may regulate the seizure susceptibility of the rats by mediating excitatory post-synaptic signaling.
Conclusion
The AMPK/PGC-1α signaling pathway may play an important role in the lithium-pilocarpine-induced epileptic rat model by mediating the expression of fusion proteins.
Fates of Nitrogenous Contaminants of Eutrophic Waters Using Laboratory Microcosm Method in Interception-Activation-Combined Bioreactors
Authors: Yu Sheng , Li Bangyu , Zhu Xiaobin , Chen Yihu , Zhang Liming , Li Jun , Zhang Yanpo , Li Chengyi 
Published: August 2022

Abstract
For understanding the internal transformations of the nitrogen in nitrogenous contaminants like ammonia nitrogen (NH3-N), nitrite nitrogen (NO2-N) and nitrate nitrogen (NO3-N) in natural waters, the remediation effects of the designed reactors on NH3-N, NO2-N and NO3-N were well carried out, respectively. It was not like the NO3-N contaminants which would be rapidly whittled down within any concentrations of this experiment, meanwhile the concentrations of the NH3-N and NO3-N contaminants were respectively reduced by nitrification and denitrification from 5.00 mg/L and 10.00 mg/L in influents under the conditions of dissolved oxygen concentrations of 5.0 ± 0.6 mg/L and the redox potential (ORP) about + 213 ± 37 mV at 20.0 ± 0.5℃ of water temperature to no more than 2.0 mg/L in effluents. Both NH3-N and NO3-N concentrations were under the limited concentrations of the level V of GB 3838 − 2002 with the help of the aerobic granular sludges (AGS) cultured and collected from the interception-reaction galleries (IRG) of the reactors of characteristics of 0.20–2.00 mm in statistical particle diameter (93 ± 4% m/m), ash contents of 7 ± 5% m/m and the degradation capacities of 0.88 ± 0.13 (mg nitrogen)/(mg sludge). Thereafter, it was not decreased as expected to the finial acceptable concentration of the prospective value of 2.00 mg/L with the original concentration of 15.00 mg/L in influents. Thus, the processes of the nitrogenous contaminants could be remediated within the concentrations of the rage of no more than 10.00 mg/L, especially both NH3-N and NO3-N to friendlily purify the natural waters without any other exogenous powers and more energy consumptions to the environment.
Genomic and immunogenomic analysis of three prognostic signature genes in LUAD
Authors: Feng Haiming , Zhao Ye , Yan Weijian , Li Bin 
Published: August 2022

Abstract
Background
Searching for immunotherapy- related markers is an important research content to screen for target populations suitable for immunotherapy. Prognosis-related genes in early stage lung cancer may also affect the tumor immune microenvironment, which in turn affects immunotherapy.
Results
We analyzed the differential genes affecting lung cancer patients receiving immunotherapy through the Cancer Treatment Response gene signature DataBase (CTR-DB), and set a threshold to obtain a total of 176 differential genes between response and non-response to immunotherapy. Functional enrichment analysis found that these differential genes were mainly involved in immune regulation-related pathways. The early-stage lung adenocarcinoma (LUAD) prognostic model was constructed through the cancer genome atlas (TCGA) database, and three target genes (MMP12, NFE2, HOXC8) were screened to calculate the risk score of early-stage LUAD. The receiver operating characteristic (ROC) curve indicated that the model had good prognostic value, and the validation set (GSE50081) from the gene expression omnibus (GEO) analysis indicated that the model had good stability, and the risk score was correlated with immune infiltrations to varying degrees. Multi-type survival analysis and immune infiltration analysis revealed that the transcriptome, methylation and the copy number variation (CNV) levels of the three genes were correlated with patient prognosis and some tumor microenvironment (TME) components. Drug sensitivity analysis found that the three genes may affect some anti-tumor drugs. The mRNA expression of immune checkpoint-related genes showed significant differences between the high and low group of the three genes, and there may be a mutual regulatory network between immune checkpoint-related genes and target genes. Tumor immune dysfunction and exclusion (TIDE) analysis found that three genes were associated with immunotherapy response and maybe the potential predictors to immunotherapy, consistent with the CTR-DB database analysis.
Conclusions
From the perspective of data mining, this study suggests that MMP12, NFE2, and HOXC8 may be involved in tumor immune regulation and affect immunotherapy. They are expected to become markers of immunotherapy and are worthy of further experimental research.
System of Additive Functional Equations in Banach Algebras
Authors: DEHGHANIAN MEHDI , PARK CHOONKIL , SAYYARI YAMIN 
Published: August 2022

Abstract
In this paper, we solve the system of functional equations f (x + y) + g(y − x) = 2f (x) g(x + y) − f (y − x) = 2g(y) and we investigate the stability of g-derivations in Banach algebras.
Study on the theory of AB-oil formation and its heat generation calculation model in ball bearings
Authors: Zhang Wenliang , Xie Xiaopeng , Huang Heng , Gao Guogang 
Published: August 2022

Abstract
Since the lubricant ejected from the oil-air lubrication system contains a large number of air bubbles. So the viscosity properties of the lubricant are changed, which in turn affects the heat generation of the ball bearing. In this paper, Fluent simulation and theoretical study were used to ascertain the formation of air bubble oil (AB-oil) in pipeline, and the void fraction of AB-oil was determined by image analysis. Theoretical analysis and experiment show that the key influencing factor of AB-oil formation is the velocity difference between air and lubricant, and the void fraction of AB-oil was affected by pipeline length, viscosity, air pressure and oil feeding. Meanwhile, the viscosity properties of AB-oil were tested by using a rheometer. The research found that AB-oil exhibits different viscosity properties at different shear rates, and then the relationships between the void fraction and viscosity at different shear rates were attained by fitting the experimental data. Based on the numerical relationship between the void fraction and viscosity, the heat generation calculation model of ball bearings was established and verified by self-made bearing testing machine.
Object Mapping for Obsolete characterization in their variation of changing movements
Authors: Pradeep M. , Naveen N 
Published: August 2022

Abstract
Mapping of an image with a dataset for categorizing the order provides variation in the movement, for computing service to acquire the model for arranging the dataset. To order model position in a dataset for computing the method in a image that sequence the order in a generating function. In order to distribute the object position of changing movements, that incurs the cross sectional fact on various position sequence. Instance to collaborate with the order of movements in various position that map the image order in position from the sequence. Order with the mapped image for order the movement position in a generated function that possess the model sequence in a coordinate generated function, mapping objects should be variable in the existing system. In the Proposed method, in the coordinate generated function in the darkened area with the minimum level as origin mapped with the ordered in the reduced sequence, Order a map to coordinate function renders the movement mapped with the function that acquire relation mapped in the order generated function.Sequence the variational coordinates in the mapped function that originate from 148963.21 in a marked value to attain those features in a darkened area with associate function.
Successful treatment of Klebsiella variicola invasive liver abscess syndrome with intracranial infection and septic shock: first reported case
Authors: Zhang Pin Jie , Cao Li Jun , Chen Hu , Sun Yun 
Published: August 2022

Abstract
Klebsiella variicola (K. variicola) is a member of the Klebsiella genus and often misidentified as Klebsiella pneumoniae. In this report, we present a rare case of invasive liver abscess syndrome caused by K. variicola, complicated with intracranial infection and septic shock. 57-year-old female patient developed fever, liver abscess, septic shock, intracranial infection. The clinical manifestations, laboratory tests and imaging examinations on admission confirmed a diagnosis of K. variicola primary liver abscess. The ultimately cured patient benefited from early percutaneous drainage of the abscess, prompt appropriate antibiotic administration and timely open surgical drainage. As far as we know, this is the first case of successful treatment of K. variicola invasive liver abscess syndrome in the world. The findings of this report point to the need for further study of epidemiology, risk factors, complications, and treatment of this disease.