bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metal contamination in a sediment core from Osaka Bay during the last 400 years
Authors: Nitzsche Kai Nils , Yoshimura Toshihiro , Ishikawa Naoto F. , Kajita Hiroto , Kawahata Hodaka , Ogawa Nanako O. , Suzuki Katsuhiko , Yokoyama Yusuke , Ohkouchi Naohiko 
Published: October 2022

AbstractOsaka Bay adjacent to the Kyoto–Osaka–Kobe metropolitan area was affected by severe metal pollution during the twentieth century; yet little is known about the trace metal sources and pre-industrial human activities. We have determined the elemental concentrations and zinc stable isotope ratios (δ66Zn) in bulk sediments and the trace metal concentrations in chemical fractions of a 9-m-long sediment core from Osaka Bay. Our goals were (1) to reconstruct the historical trace metal contamination, and (2) to identify anthropogenic Zn sources and the solid phases of anthropogenic trace metals. The core provided a continuous environmental record of the last 2300 years based on radiocarbon dating of molluscan shells. Copper, Zn, and Pb showed an initial enrichment from the 1670s AD, which could be caused by human activities due to an increasing population. In agreement with previous findings, the trace metal concentrations slightly increased from the 1870s, strongly increased from the beginning of the twentieth century, and peaked around 1960 before environmental pollution control laws were enacted. Increasing trace metal concentrations in the acid-labile and reducible fractions obtained by the Community Bureau of Reference (BCR) sequential extraction procedure toward the surface indicate carbonates and Mn oxyhydroxides were the primary fractions for anthropogenic trace metals. The δ66Zn values (1) were constant until the 1940s, suggesting that the average δ66Zn of industrial sources was indistinguishable from that value of the natural background, (2) showed a slight decrease from the 1950s and remained constant until the present, and (3) fell in a binary mixing process between a lithogenic (~ + 0.27‰) and an anthropogenic endmember (~ + 0.17‰), the latter likely representing a mixture of various Zn sources such as road dust, tire wear, industrial effluents, and effluents from wastewater treatment plants. We conclude the combination of Zn stable isotopes together with chemical fractions obtained by the BCR method represents a promising approach to assess the trace metal sources and their potential mobility in sediment cores from anthropogenically affected coastal areas.
Shortened duration whole body 18F-FDG PET Patlak imaging on the Biograph Vision Quadra PET/CT using a population-averaged input function
Authors: van Sluis Joyce , van Snick Johannes H. , Brouwers Adrienne H. , Noordzij Walter , Dierckx Rudi A. J. O. , Borra Ronald J. H. , Lammertsma Adriaan A. , Glaudemans Andor W. J. M. , Slart Riemer H. J. A. , Yaqub Maqsood , Tsoumpas Charalampos , Boellaard Ronald 
Published: October 2022

Abstract
Background
Excellent performance characteristics of the Vision Quadra PET/CT, e.g. a substantial increase in sensitivity, allow for precise measurements of image-derived input functions (IDIF) and tissue time activity curves. Previously we have proposed a method for a reduced 30 min (as opposed to 60 min) whole body 18F-FDG Patlak PET imaging procedure using a previously published population-averaged input function (PIF) scaled to IDIF values at 30–60 min post-injection (p.i.). The aim of the present study was to apply this method using the Vision Quadra PET/CT, including the use of a PIF to allow for shortened scan durations.

Methods
Twelve patients with suspected lung malignancy were included and received a weight-based injection of 18F-FDG. Patients underwent a 65-min dynamic PET acquisition which were reconstructed using European Association of Nuclear Medicine Research Ltd. (EARL) standards 2 reconstruction settings. A volume of interest (VOI) was placed in the ascending aorta (AA) to obtain the IDIF. An external PIF was scaled to IDIF values at 30–60, 40–60, and 50–60 min p.i., respectively, and parametric 18F-FDG influx rate constant (Ki) images were generated using a t* of 30, 40 or 50 min, respectively. Herein, tumour lesions as well as healthy tissues, i.e. liver, muscle tissue, spleen and grey matter, were segmented.

Results
Good agreement between the IDIF and corresponding PIF scaled to 30–60 min p.i. and 40–60 min p.i. was obtained with 7.38% deviation in Ki. Bland–Altman plots showed excellent agreement in Ki obtained using the PIF scaled to the IDIF at 30–60 min p.i. and at 40–60 min p.i. as all data points were within the limits of agreement (LOA) (− 0.004–0.002, bias: − 0.001); for the 50–60 min p.i. Ki, all except one data point fell in between the LOA (− 0.021–0.012, bias: − 0.005).

Conclusions
Parametric whole body 18F-FDG Patlak Ki images can be generated non-invasively on a Vision Quadra PET/CT system. In addition, using a scaled PIF allows for a substantial (factor 2 to 3) reduction in scan time without substantial loss of accuracy (7.38% bias) and precision (image quality and noise interference).
Clinical Outcome Following Concussion Among College Athletes with a History of Prior Concussion: A Systematic Review
Authors: Gaudet Charles E. , Iverson Grant L. , Kissinger-Knox Alicia , Van Patten Ryan , Cook Nathan E. 
Published: October 2022

AbstractBackgroundThere is long-standing interest in, and concern about, whether collegiate athletes with a history of concussion will experience worse clinical outcomes, or prolonged recovery, should they sustain a subsequent concussion.ObjectivesThis systematic review examined the association between prior concussion history and clinical outcomes following a subsequent sport-related concussion among college-age student athletes.Study DesignSystematic review.MethodsWe screened 5,118 abstracts and 619 full-text articles that were appraised to determine whether they met inclusion criteria. We utilized a likelihood heuristic to assess the probability of observing a specific number of statistically significant and nonsignificant studies reporting an association between concussion history and clinical outcomes. We conducted a narrative synthesis of the study findings.ResultsSixteen studies met the inclusion criteria. Thirteen studies reported the number of participants with a history of prior concussions (≥ 1), which totaled 1690 of 4573 total participants (on average 37.0% of study participants; median = 46.0%, range 5.6–63.8%). On the Newcastle–Ottawa Quality Assessment Scale, the risk of bias ratings ranged from 3 to 9 (mean = 5.4, SD = 1.4). Across all studies, 43.8% (k = 7/16) reported at least one statistically significant result among primary analyses showing an association between concussion history and worse clinical outcome. A minority of studies reporting on symptom duration (4/13, 30.8%) and time to return to play (2/7, 28.6%) found an association between concussion history and worse outcome. Studies included in the review reported limited information pertaining to the characteristics of prior concussions, such as presence or duration of loss of consciousness or posttraumatic amnesia, age at first lifetime concussion, time since most recent past concussion, or length of recovery from prior concussions.ConclusionThe question of whether college athletes with a prior history of concussion have worse clinical outcome from their next sport-related concussion remains unresolved. The published results are mixed and in aggregate show modest evidence for an association. Many studies have small samples, and only three studies were designed specifically to address this research question. Important outcomes, such as time to return to academics, have not been adequately studied. Larger hypothesis-driven studies considering the number of prior concussions (e.g., 3 or more) are needed.Trial registration: PROSPERO CRD42016041479, CRD42019128300.
Failed spinal anesthesia due to accidental dural puncture: a case report
Authors: Honda Jun , Yamazaki Yuki , Yakushiji Tatsumi , Hirata Hinako , Inoue Satoki 
Published: October 2022

Abstract
Background
We present a case of inadequate spinal anesthesia possibly due to cerebrospinal fluid (CSF) leakage into the epidural space caused by accidental dural puncture (ADP).

Case presentation
A 28-year-old woman with twin pregnancy underwent a cesarean section. She was scheduled to undergo combined spinal-epidural anesthesia (CSEA). Hyperbaric bupivacaine 9 mg with fentanyl 15 μg, with an additional bupivacaine 5 mg was administered from the L3/4 interspace for spinal anesthesia after repeated ADP at T12/L1; however, analgesia level was only up to T12. Insufficient analgesia level would be attributed to leakage of bupivacaine into the epidural space with the CSF via the injured dura. Planned surgery was performed under general anesthesia and completed uneventfully.

Conclusion
In spinal anesthesia performed after ADP in pregnant women, the anesthesia level may not increase as expected if there is a large amount of CSF leakage.
“We start where we are”: a qualitative study of barriers and pragmatic solutions to the assessment and reporting of implementation strategy fidelity
Authors: Akiba Christopher F. , Powell Byron J. , Pence Brian W. , Muessig Kate , Golin Carol E. , Go Vivian 
Published: October 2022

Abstract
Background
Fidelity measurement of implementation strategies is underdeveloped and underreported, and the level of reporting is decreasing over time. Failing to properly measure the factors that affect the delivery of an implementation strategy may obscure the link between a strategy and its outcomes. Barriers to assessing and reporting implementation strategy fidelity among researchers are not well understood. The aims of this qualitative study were to identify barriers to fidelity measurement and pragmatic pathways towards improvement.

Methods
We conducted in-depth interviews among researchers conducting implementation trials. We utilized a theory-informed interview approach to elicit the barriers and possible solutions to implementation strategy fidelity assessment and reporting. Reflexive-thematic analysis guided coding and memo-writing to determine key themes regarding barriers and solutions.

Results
Twenty-two implementation researchers were interviewed. Participants agreed that implementation strategy fidelity was an essential element of implementation trials and that its assessment and reporting should improve. Key thematic barriers focused on (1) a current lack of validated fidelity tools with the need to assess fidelity in the short term, (2) the complex nature of some implementation strategies, (3) conceptual complications when assessing fidelity within mechanisms-focused implementation research, and (4) structural issues related to funding and publishing. Researchers also suggested pragmatic solutions to overcome each barrier. Respondents reported using specification and tracking data in the short term until validated tools become available. Participants suggested that researchers with strategy-specific content expertise lead the way in identifying core components and setting fidelity requirements for them. Addressing the third barrier, participants provided examples of what pragmatic prospective and retrospective fidelity assessments might look like along a mechanistic pathway. Finally, researchers described approaches to minimize costs of data collection, as well as more structural accountability like adopting and enforcing reporting guidelines or changing the structure of funding opportunities.

Discussion
We propose short- and long-term priorities for improving the assessment and reporting of implementation strategy fidelity and the quality of implementation research.

Conclusions
A better understanding of the barriers to implementation strategy fidelity assessment may pave the way towards pragmatic solutions.
Partial nasal bone reconstruction with acrylic bone cement: experimental study
Authors: Karataş Halil Altın , Karakoç Ömer , Ocal F. Ceyda Akın , Bınar Murat , Kılınç Melih 
Published: October 2022

Abstract
Background
The aim of this study was to evaluate the effectiveness of acrylic bone cement in partial nasal bone reconstruction.

Methods
This study was conducted using nine New Zealand rabbits. The left nasal bones of the rabbits were included in the experimental group, and the right nasal bones were evaluated as the control group. The partial bone segments on the bilateral nasal bones were marked and removed symmetrically. A synthetic graft material made of acrylic bone cement was placed in experimental group, and the partial bone segment removed from the right side was placed in control group as an autograft. All rabbits were sacrificed at the end of the 28th day. Samples were taken from the grafts and from the surrounding soft tissues for histopathological examination. Acute inflammation, chronic inflammation, vascularization, fibrosis, foreign body reaction, bone proliferation, and the presence of empty lacunae were evaluated under a light microscope for both groups.

Results
Surrounding soft tissue on synthetic and autograft were the same in terms of chronic inflammation. There was no statistically significant difference for vascularization, fibrosis, and foreign body reaction. Synthetic graft and autograft were the same in terms of chronic inflammation, fibrosis, and bone proliferation. There was no statistically significant difference for vascularization, foreign body reaction, and presence of empty lacunae (p > 0.05).

Conclusion
This study showed no significant differences between the use of acrylic bone and the use of an autograft for partial nasal bone reconstruction in terms of graft or tissue healing. Acrylic bone cement may therefore serve as a good alternative for nasal bone reconstruction.
Is Routine Omentectomy a Necessary Component of Cytoreductive Surgery and HIPEC?
Authors: Khan Sohini , Doan Nguyen-Huong , Hosseini Mojgan , Kelly Kaitlyn , Veerapong Jula , Lowy Andrew M. , Baumgartner Joel 
Published: October 2022

Abstract
Background
Cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases traditionally includes omentectomy, even in the absence of visible omental metastases. We sought to determine the rate of occult histologic omental metastasis (OHOM), evaluate morbidity with omentectomy, and examine the rate of omental recurrence among patients undergoing CRS-HIPEC.

Methods
All CRS-HIPEC procedures from August 2007 to August 2020 were included in this single-center, retrospective, cohort study. Procedures were divided into those that included greater omentectomy (OM) and those that did not (NOM). The incidence of OHOM was evaluated specifically among the OM group with a grossly normal omentum. Multivariate regression analyses were performed to evaluate return of bowel function, ileus, and morbidity in the OM and NOM groups.

Results
Among 683 CRS-HIPEC procedures, 578 (84.6%) included omentectomy and 105 (15.4%) did not. The OM group had higher operative time, blood loss, peritoneal cancer index, number of visceral resections, and length of stay. In the OM group, 72 (12.5%) patients had a grossly normal omentum, and 23 (31.9%) of these had OHOM. Risk-adjusted return of bowel function, ileus, and 60-day complications were no different in the OM and NOM groups. Among 43 patients with residual omentum, 24 (55.8%) recurred, including 9 (20.9%) with omental recurrence.

Conclusions
Histologically occult metastasis was present in one-third of patients undergoing omentectomy during CRS-HIPEC. Omentectomy did not increase the rate of overall morbidity, and one-fifth of patients with residual omentum later developed omental recurrence. Thus, omentectomy is warranted in the absence of gross metastases during CRS-HIPEC.
Investigation of Bacterial Persistence and Filaments Formation in Clinical Klebsiella pneumoniae
Authors: Aziz Sarah N. , Al Marjani Mohammed F. 
Published: October 2022

Bacterial persistence is recognized as a major cause of antibiotic therapy failure, causing biofilms, and chronic intractable infections. The emergence of persisters in Klebsiella pneumoniae isolates has become a worldwide public health concern. The goal of the present study is to investigate the formation of persister cells beside filaments in Iraqi K. pneumoniae isolates. A total of fifty clinical K. pneumoniae isolates were collected from different clinical specimens and identified using the genotypic identification by using specific primer (rpoB gene) from housekeeping genes. Persister cells investigation is performed by exposure of stationary phase K. pneumoniae isolates to a high concentration of ciprofloxacin (×10 MIC) and counting the number of viable persister cells by CFU counts. Bacterial filament formation is detected and measured by light microscope scanning electron microscope. The results show the bility of these pathogenic bacteria to form persister cells to survive the bactericidal antibiotics and to cause chronic infection.Furthermore, persistent isolates have the ability to change in shape and size extensively, about 4 times increase in cell length than their normal length. These phenomena are possibly the initial stages of bacterial resistance prevalence.
Animalia tantum
. The “ritual role” of animals in Middle Bronze Age funerary contexts in the highlands
Authors: Cesaretti Andrea 
Published: October 2022

Abstract
Animal burials are very common in the ancient world; the practice was widespread and had different meanings, ranging from offerings to the deceased to ritual banquets. Archaeology can only partially reconstruct the multitude of symbols connected with human burials associated with the interment of animals. In Armenia, and more generally in the Southern Caucasus, between the 3rd and 2nd millennium BC, during the protohistoric period known as the Middle Bronze Age, the burials were by typically covered by a mound, locally known as a kurgan. One of the most significant features of the deposition is the presence of numerous wild and domestic animals. This paper analyses the interment of animals from a symbolic perspective and puts forward hypotheses regarding their role in human burial customs.
Peningkatan Kompetensi Warga Belajar PKBM Ad-Da’wah Melalui Pelatihan Pengolahan Potensi Lokal
Authors: Hermawan Yudan , Yusup Ujang Dede 
Published: October 2022

Tujuan penelitian ini adalah untuk mendiskripsikan upaya peningkatan kompotensi warga belajar melalui pelatihan pengolahan potensi lokal di Pusat Kegiatan Belajar Masyarakat (PKBM) Ad-Da’wah merupakan salah satu lembaga pendidikan non-formal di kecamatan Cibadak Kabupaten Sukabumi. Untuk mengidentifikasi persoalan tersebut secara mendalam dan menyeluruh peneliti menggunakan metode penelitian kualitatif dengan Teknik pengumpulan data wawancara, observasi dan dokumentasi. Hasil dari penelitian ini: a) Tahap pertama adalah persiapan. Tahap ini dilakukan dengan identifikasi kebutuhan (need asessment) terlebih dahulu sebagai langkah awal penyusunan program dan dilakukan dengan metode analisis SWOT. b) Pelaksanaan. Penyampaian materi program pelatihan pengolahan nugget pisang toping coklat lumer ini disampaikan secara online dan ofline. Secara online dilaksanakan melalui Whatsapp dan secara ofline dilaksanakan dilingkungan PKBM yaitu praktik langsung pembuatan nugget pisang toping coklat lumer. Mekanisme pelaksanaan pelatihan ini dilaksanakan dalam dua kali pertemuan. Pada pertemuan pertama kegiatan pelatihan difokuskan pada penyampian materi secara online dan pertemuan kedua kegiatan pelatihan berfokus pada praktik langsung pembuatan nugget pisang toping coklat lumer. c). Evaluasi. Hasil dari pelatihan pengolahan nugget pisang toping coklat lumer ini mampu memberikan peningkatan pengetahuan dan keterampilan bagi warga belajar PKBM Ad-Da’wah dalam pengolahan potensi lokal pisang menjadi nugget pisang toping coklat lumer
Calidad de los Contratos Inteligentes en la Blockchain
Authors: Montoya Acevedo Antonio José , Montoya Quintero Diana María 
Published: October 2022

Los contratos inteligentes han ganado más terreno en las industrias en sus procesos debido a la confiabilidad de la tecnología Blockchain o cadena de bloques, dado que brinda la seguridad en las transacciones; todo esto conlleva un desafío y es el cómo se certifica el proceso y a su vez brindar confiabilidad, para ello debe pasar por procesos o estándares de calidad que actualmente son de alta competencia dado a que es una tecnología innovadora y nueva en el mercado. Sin duda alguna el termino de calidad hace referencia a lo que permite caracterizar o valorar ya sea un producto o servicio, desde esta perspectiva la calidad sea vuelto undesafío para las industrias y se han conformado grupos focales en cómo lograr que los productos lleguen a los estándares que se requiere paraque el producto o servicio cuente con el mínimo viable para su aprobación. De esta manera la calidad no solo les compete a las industrias sino también a las instituciones de educación que es donde segesta o se formula los lineamientos de calidad. A partir de lo anterior se considera que, si la gestión del conocimiento entre las instituciones deeducación y la industria trabajan en mejorar la calidad en la certificación inteligente apoyándose en la tecnología Blockchain, se pueden mejorar los procesos y cumplir con estándares donde se logre ser más competitivos a nivel nacional e internacional.
Aproximaciones al concepto de gobernanza universitaria: una revisión desde la normativa colombiana
Authors: González-Gil Eduardo , Carreño Dueñas Dalia 
Published: October 2022

Lo propio de las universidades, es que se conformen en centros de creación y producción de conocimiento y, por lo tanto, de conceptos. De ahí que es oportuno y conveniente, como es el objetivo de este proyecto, proponer una posible noción de la gobernanza universitaria, como concepto derivado, polisémico, en centro de tensiones, pero, a la vez, posee un carácter abierto, complejo, paradigmático (por su polisemia) y sin duda, por su naturaleza, crítico. Las instituciones universitarias se hallan organizadas, poseen un gobierno y una gestión, lo que les facilita las relaciones de poder con la comunidad, con los actores que lidera, y la presencia e interrelación en el medio externo. La aproximación al concepto de gobernanza universitaria, como pregunta que se resuelve en este trabajo, lo define como el ejercicio de integración del gobierno institucional, la gobernabilidad y la gestión para garantizar la interacción de los grupos de interés para el logro de la misión institucional y la interacción con el entorno. Algunos aspectos que conforman, su arquitectura son los que se refieren al gobierno universitario, la gobernabilidad universitaria, la gestión y la política de buen gobierno. La metodología es de carácter documental, reconstructivo y hermenéutico dentro del diseño cualitativo.
Domótica: Una panorámica
Authors: Matías Ignacio R. , López-Amo Manuel 
Published: October 2022

El concepto de domótica, a la vez que novedoso, está desarrollándose en el presente a gran velocidad. Por ello, es necesario dar una
panorámica de esta nueva tecnología para entender algo mejor el estado actual de su desarrollo y la forma en que se puede aplicar a cada uno de los usuarios. En la actualidad, existen muchos sistemas comercializado, si bien, hay que saber cuál de ellos aplicar para construir los edificios "a prueba de futuro".