bluuebunny/crossref_metadata_2025_split huggingface dataset:
P406 UNMASKING A PATTERN OF BRUGADA: FLECAINIDE VS AJMALINA
Authors: Gioia M , Caroli G , Milo M , Medico A , Ignone G 
Published: May 2022

Abstract
Brugada syndrome mainly affects men in the third and fourth decade of life. It presents with a typical electrocardiographic pattern, unmasked by sodium channel blocking drugs or hyperpyrexia. A 36–year–old young man, with no reported cardiovascular risk factors or family history of sudden death, had convulsions and loss of consciousness during hyperpyrexia, for which family members alerted the local emergency service. During transport to the hospital, the vital parameters and heart rhythm were normal, but, due to the onset of seizures, the patient was sedated, intubated and hospitalized in intensive care unit (ICU). The ECG performed at the entrance (in the course of hyperpyrexia) showed a dubious type 1 Brugada pattern (Figure 1). The echocardiogram (as well as the subsequent cardiac resonance) showed the absence of cardiac structural alterations. Prompt treatment of hyperpyrexia was recommended, the use of drugs listed on brugadadrugs.org was contraindicated and careful ECG monitoring was recommended. Non–sustained ventricular tachycardia was documented during the hospitalization in ICU. When the clinical picture stabilized with resumption of spontaneous breathing, the patient was transferred to our ICU for continuation of the diagnostic and therapeutic process (Figure 2). From the interview with the patient, a previous paroxysmal tachycardia from atrio–ventricular reentry emerged in antiarrhythmic prophylaxis for several years with Propafenone and subsequently treated with catheter ablation of the right lateral accessory path. Considering the lack of documentation of complex ventricular arrhythmias by the 118 during transport to the hospital and during the stay in the UTIC, the long antiarrhythmic therapy with sodium channel inhibitors, as well as the absence of a typical Brugada pattern during fever, we decide to perform a Flecainide test (2 mg / Kg in 10 ‘), negative result for Brugada type 1 pattern (Figure 2) In the following days, considering the absolute negativity of all the neuroradiological and EEG investigations, not having found the cause of the loss of consciousness during hyperpyrexia, we performed ajmaline test (1 mg / kg in 100 cc of SG5% in 10 ‘) with the identification of the diagnostic pattern type 1 (Figure 3). Finally, the implantation of a subcutaneous cardioverting defibrillator (S–ICD) was performed.
P409 CARDIAC SYMPATHOMIMETIC RESPONSE IN PARKINSON‘S PATIENTS VS HEALTHY ADULTS
Authors: Regolanti R , Bagni O , Cannas P , Raponi M , Denaro A , Alessandri N 
Published: May 2022

Abstract

In recent works, it has been observed that cardiac sympathetic innervation contributes to the hemodynamic adaptations of the cardiovascular system, in relation to numerous needs. Orimo et al, through the use of scintigraphy with MIBG, showed in Parkinson‘s patients a marked reduction in myocardial uptake of MIBG corresponding to cardiac sympathomimetic denervation, in relation to the severity of the disease.
The aim of this work was to evaluate the morpho–functional variations of the heart at a programmed sympathomimetic stimulus (dopamine test), both in healthy patients and in those suffering from Parkinson‘s disease.

Materials and Methods
At the University Cardiology “La Sapienza” of Rome, Pontine Polo, 10 patients affected by PD (age 56±5,5, of which 6 M and 4 W) and 10 healthy (54±6,4, of which 6M,4W)were tested in the absence of cardiovascular FR; all patients performed: blood chemistry, ECG, chest x–ray, Eco–TSA, tilt test, echocardio– Dopamine (2D–stress) and MIBG Scintigraphy. 2D–stress echocardiogradia was assessed by t–student of F.acc + EF + left and right diastolic times + GLS + Tapse + PAPS at 10, 20.30.40 µ dopa and their correlation (r–pearson) in the two groups.

Discussion
The observation of the data in the two groups of patients, in the absence of ongoing and remote cardiological pathology, showed a behavior of the values in the range both in basal conditions and during dopa stimulation. The comparison of the two groups both basal and during progressive dose stimulation that a statistical difference (P &lt; 0.05) is observed on both systolic and diastolic function. The comparison in the two groups in the different stimulus phases showed a parallel growth behavior but with a different speed (Dp / Dv). There is no single explanation for these results: certainly the central role is played by the poor representation of post–ganglionic nerve endings as well as by the significant reduction of cardiac adrenergic receptors in Parkison.

Conclusion
The small number of patients and the data observed, stimulates researchers to continue the study, to better understand which pathophysiological mechanisms underlie these observations and verify the presence of an inverse relationship between PD and all those cardiological pathologies caused by catecholaminergic hyperstimulus.
P412 SCAD: A PLANET TO DISCOVER IN THE UNIVERSE OF ACS
Authors: Bertolini D , Armillotta M , Bergamaschi L , Bertelli M , Di Nicola F , Sansonetti A , Donati F , Pizzi C , Galiè N 
Published: May 2022

Abstract
We hereby present the case of a 36–year–old woman with neither a history of cardiovascular disease nor any cardiovascular risk factors. Her only past medical history included a pregnancy from in vitro fertilization and endometriosis treated with progestin. She was admitted to A&E for sudden onset severe stabbing thoracic pain, which occurred at rest and was exacerbated by respiratory efforts, and with spontaneous resolution shortly after admission. While the ECG did not show any signs of ischemic, blood tests revealed a minor rise in inflammatory markers and a significant rise in troponin values, the latter consistent with acute myocardial injury.
Given the clinical suspicion of myopericarditis vs acute coronary syndrome, the patient was admitted to cardiac intensive care unit. Bedside echocardiogram performed shortly after admission demonstrated minor pericardial effusion and regional wall motion abnormalities. Thus, the patient underwent urgent coronary angiography, which revealed pronounced vasospasm at the proximal segment of the circumflex artery, which subsided after administration of nitrate, as well as spontaneous dissection of the mid left anterior descending artery extending to its apical branch. Since no high–risk features were identified (single vessel, mid–distal coronary lesion, no symptoms of persistent ischemia), revascularisation was not attempted and conservative therapy was undertaken. During the following days, genetic evaluation and further diagnostic tests were performed to exclude vascular abnormalities in other anatomical sites, which all resulted negative. Outpatient follow–up with CT coronary angiogram demonstrated full patency of left anterior descending artery with spontaneous resolution of the former dissection.
This clinical scenario represents an example of an uncommon and thus often overlooked cause of acute coronary syndrome with yet limited evidence on optimal therapeutic and follow–up strategies.
Investing in Late-Life Brain Capital
Authors: Dawson Walter D , Smith Erin , Booi Laura , Mosse Maia , Lavretsky Helen , Reynolds Charles F , Cummings Jeffrey , Brannelly Patrick , Hynes William , Lenze Eric J , Manes Facundo , Ayadi Rym , Frank Lori , Chapman Sandra Bond , Robertson Ian H , Rubenstein Lori , Jraissati Jorge , Ibáñez Agustin , Fillit Howard , Jeste Dilip V , Rao Anitha , Berk Michael , Storch Eric A , Santuccione Chadha Antonella , Eyre Harris A 
Published: May 2022

Abstract
Within many societies and cultures around the world, older adults are too often undervalued and underappreciated. This exacerbates many key challenges that older adults may face. It also undermines the many positive aspects of late life that are of tremendous value at both an individual and societal level. We propose a new approach to elevate health and well-being in late life by optimizing late-life Brain Capital. This form of capital prioritizes brain skills and brain health in a brain economy, which the challenges and opportunities of the 21st-century demands. This approach incorporates investing in late-life Brain Capital, developing initiatives focused on building late-life Brain Capital.
Selecting and modelling remnant AGNs with limited spectral coverage
Authors: Quici Benjamin , Turner Ross J , Seymour Nicholas , Hurley-Walker Natasha , Shabala Stanislav S , Ishwara-Chandra C H 
Published: May 2022

ABSTRACT
Quantifying the energetics and lifetimes of remnant radio-loud active galactic nuclei (AGNs) is much more challenging than for active sources due to the added complexity of accurately determining the time since the central black hole switched off. Independent spectral modelling of remnant lobes enables the derivation of the remnant ratio, Rrem (i.e. ‘off-time/source age’); however, the requirement of high-frequency (≳5 GHz) coverage makes the application of this technique over large-area radio surveys difficult. In this work, we propose a new method, which relies on the observed brightness of backflow of Fanaroff–Riley type II lobes, combined with the Radio AGN in Semi-Analytic Environments (RAiSE) code, to measure the duration of the remnant phase. Sensitive radio observations of the remnant radio galaxy J2253-34 are obtained to provide a robust comparison of this technique with the canonical spectral analysis and modelling methods. We find that the remnant lifetimes modelled by each method are consistent; spectral modelling yields Rrem = 0.23 ± 0.02, compared to Rrem = 0.26 ± 0.02 from our new method. We examine the viability of applying our proposed technique to low-frequency radio surveys using mock radio source populations, and examine whether the technique is sensitive to any intrinsic properties of radio AGNs. Our results show that the technique can be used to robustly classify active and remnant populations, with the most confident predictions for the remnant ratio, and thus off-time, in the longest lived radio sources (&gt;50 Myr) and those at higher redshifts (z &gt; 0.1).
The initial conditions for young massive cluster formation in the Galactic Centre: convergence of large-scale gas flows
Authors: Williams Bethan A , Walker Daniel L , Longmore Steven N , Barnes A T , Battersby Cara , Garay Guido , Ginsburg Adam , Gomez Laura , Henshaw Jonathan D , Ho Luis C , Kruijssen J M Diederik , Lu Xing , Mills Elisabeth A C , Petkova Maya A , Zhang Qizhou 
Published: May 2022

ABSTRACT
Young massive clusters (YMCs) are compact (≲1 pc), high-mass (&gt;104 M⊙) stellar systems of significant scientific interest. Due to their rarity and rapid formation, we have very few examples of YMC progenitor gas clouds before star formation has begun. As a result, the initial conditions required for YMC formation are uncertain. We present high resolution (0.13 arcsec, ∼1000 au) ALMA observations and Mopra single-dish data, showing that Galactic Centre dust ridge ‘Cloud d’ (G0.412 + 0.052, mass = 7.6 × 104 M⊙, radius = 3.2 pc) has the potential to become an Arches-like YMC (104 M⊙, r ∼ 1 pc), but is not yet forming stars. This would mean it is the youngest known pre-star-forming massive cluster and therefore could be an ideal laboratory for studying the initial conditions of YMC formation. We find 96 sources in the dust continuum, with masses ≲3 M⊙ and radii of ∼103 au. The source masses and separations are more consistent with thermal rather than turbulent fragmentation. It is not possible to unambiguously determine the dynamical state of most of the sources, as the uncertainty on virial parameter estimates is large. We find evidence for large-scale (∼1 pc) converging gas flows, which could cause the cloud to grow rapidly, gaining 104 M⊙ within 105 yr. The highest density gas is found at the convergent point of the large-scale flows. We expect this cloud to form many high-mass stars, but find no high-mass starless cores. If the sources represent the initial conditions for star formation, the resulting initial mass function will be bottom heavy.
European Physico-theology (1650-c.1760) in Context
Authors: von Greyerz Kaspar 
Published: May 2022

Abstract
Physico-theology harnessed the observation of nature to the recognition of God as Creator and to a demonstration of the compatibility of the biblical record with the new science. The new science emerged from the mid-seventeenth century. The present book offers the first study in English of physico-theology on a European scale. Its main argument is that physico-theology not only grew into an intellectual movement across Protestant Europe from the late seventeenth century onward, but that it was substantially different from the mainstream of traditional natural theology. The most prominent protagonists of the movement were virtuosi, especially clergy and physicians. European Physico-theology … in Context investigates in particular two physico-theological genres: the argument from design and diluvialism (i.e. the connection established between the biblical Flood and the existence of fossils). It also looks at practice in the exchange of natural objects, the establishment of collections, and the scientific efforts in taxonomy which they called for. Religion is not seen as an obstacle to the spread of science but as a factor in enhancing the interest of literate and educated people in acquiring natural knowledge. This can be maintained even though physico-theology was above all a Protestant concern owing to the kind of biblicism that the Protestant scientists and virtuosi brought to bear on their study of nature. After the mid-eighteenth century the movement split up into different currents, but in the Netherlands and Britain its mainstream continued to demonstrate a remarkable vitality, surviving well into the nineteenth century.
Conclusion
Authors: von Greyerz Kaspar 
Published: May 2022

Abstract
The conclusion draws attention to the following themes. First, the discussion of the critique of the argument from design by David Hume and Immanuel Kant drawing a clear line between metaphysics and natural philosophy, a division that physico-theology implicitly rejected. Second, the conclusion recalls the long lease of life which physico-theology enjoyed in Britain, as well as in the Netherlands, in spite of Hume’s and Kant’s interventions. Elsewhere on the continent we can distinguish a diversification of physico-theology in the second half of the eighteenth century into three currents: the continuation of mainstream physico-theology; a tendency to increase Christian apology; and, thirdly, the utilitarian resetting of physico-theology which ultimately resulted in an entirely secularized form of reasoning. However, the course taken by physico-theology after the mid-century should not obscure the fact that the role of European physico-theology in preparing the ground for a positive reception of new scientific knowledge among the educated classes and beyond should by no means be underestimated.
‘To commemorate the English character’
Authors: Reynolds Luke 
Published: May 2022

Abstract
This chapter completes the shift towards materiality, discussing a variety of physical commemorations including Waterloo Bridge, various forms of commemorative naming, official and unofficial medals, household items, clothing, vegetables, and even snuff. By casting a wider net than surveys of military monuments traditionally engage with, this chapter demonstrates that permanent and semi-permanent commemoration in the form of namings and material culture was not only one of the most widespread forms of commemoration but also a virtually uncontested form of nationalization, as Waterloo went from a battle to a bridge, multiple streets, hotels, and businesses. Finally, to demonstrate the ubiquity of Waterloo commemoration in the national conversation, it briefly explores the efforts by satirists to ‘commemorate’ Peterloo using identical methods, thus further enforcing the link between Waterloo and the St Peter’s Field Massacre.
Epilogue
Authors: Reynolds Luke 
Published: May 2022

Abstract
This epilogue is centred around the funeral of the Duke of Wellington in 1852. In the national outpouring of grief that marked Wellington’s death, his funeral, and the two months in between, we see a public demonstration of the shared ownership and nationalization of Waterloo and the culmination of the themes examined in this book. Wellington’s funeral was a national spectacle in every sense, and it highlights just how firmly entrenched Waterloo was in Britain’s national—and civic—identity. The epilogue concludes with a coda discussing the bicentennial in 2015. Between the funeral and the bicentennial, it becomes clear how complicated cultural ownership of Waterloo became and how that cultural legacy is just as significant as its military or political legacy.
LGBTQ Rights Mobilization and Authoritarianism
Authors: Chua Lynette J. 
Published: May 2022

Abstract
LGBTQ (lesbian, gay, bisexual, transgender, and queer) rights and authoritarianism are social phenomena whose features vary across political, social, and legal contexts. Layers of authoritarianism coexist, taking the shape of authoritarian states and enclaves within both authoritarian and liberal states. All these different forms of authoritarianism can affect the living conditions of sexual and gender minorities or their ability and willingness to claim for what is now widely known as LGBTQ rights. However, authoritarian conditions do not solely determine the development of LGBTQ rights. Advocates of LGBTQ rights can sometimes overcome the conditions that constrain rights mobilization and sometimes successfully challenge those that oppress sexual and gender minorities. LGBTQ rights emerge from such acts of mobilization, which are political processes through which actors interpret their encounters with authoritarian conditions and tailor their responses according to who and where they are, including whether or not to use rights.
Women, Peace, and Security
Authors: Chinkin Christine 
Published: May 2022

Abstract
The Women, Peace and Security (WPS) agenda emanates from the ground-breaking Security Council Resolution 1325 (2000) which centres upon bringing women’s experiences of armed conflict into decision and policymaking in the exercise of the Council’s primary responsibility for the maintenance of international peace and security. The chapter asks whether, despite its location within the Security Council, WPS can be understood as an international human rights agenda as envisaged by women activists who lobbied for the adoption of Resolution 1325. It traces the antecedents of WPS through women’s peace and human rights activism throughout the twentieth century. It examines the texts of the first two WPS resolutions, 1325 (2000) and 1820 (2008) in some detail to determine the extent to which they can be understood as human rights instruments and contrasts the Security Council resolutions with General Recommendation No. 30 adopted by the CEDAW Committee, an overtly human rights approach to the same subject matter. It concludes that mobilization today around the WPS agenda is not so much about advancement of women’s rights as retaining the headway made in Resolution 1325.
International NGOs and the (Non) Mobilization of Human Rights in the Context of Climate Change
Authors: Lock Rebecca , Vanhala Lisa 
Published: May 2022

Abstract
There is growing recognition that climate change constitutes an unprecedented threat to human rights. Why then do some international NGOs mobilize human rights in the context of climate change whereas others do not? This chapter explores the mobilization of a human rights framing of climate change by five key INGOs. The chapter draws on sociological institutionalist approaches to identify the factors that matter in accounting for variation in the turn to a human rights framing of climate change. We find that while some features of organizational identity—sector, type, mandate, and brand—are often evoked as reasons for the non-engagement with a human rights framing of climate change, none of these factors account for the variation in public-facing engagement that we document. Instead, we find that the way staff perceive an organization’s identity and its fit with the human rights and climate change frame is influential in shaping whether an organization mobilizes on the issue.
Who Develops Sjögren’s?
Authors: Lee Christine H. , Wallace Daniel J. 
Published: May 2022

Abstract
Although Sjögren’s disease is most often diagnosed in women who are of middle age or older, the disease can occur in anyone. In fact, as awareness of this disease increases, it is being increasingly recognized in younger people and in men. In the United States, one in 83 residents has features of Sjögren’s disease. Patients who are diagnosed with Sjögren’s disease are at an increased risk of being diagnosed with additional autoimmune disorders and complications, including lymphoma. Though no geographic, racial, or ethnic features have been associated with Sjögren’s disease, the incidence of autoimmune disease in family members is increased.
The Cost of Living with Sjögren’s
Authors: Bowman Simon J. , Fisher Benjamin 
Published: May 2022

Abstract
Determining the financial cost of Sjögren’s disease to a patient is difficult because it may include a wide range of direct and indirect costs. Direct costs related to Sjögren’s may include doctor’s visits, medications, lab tests, and much more. Indirect costs may include reduced ability to work, disability, and increased insurance premiums. However, the true financial burden can include many additional factors, and the impact on the individual will vary. This chapter explores a variety of studies that have been conducted to determine the financial cost of Sjögren’s and argues for the development of novel therapies to treat the disease.
Environmental Effects
Authors: Wilson Jeffrey W. , Olsson Peter , Mandl Thomas 
Published: May 2022

Abstract
Our environments contribute to our overall health and can sometimes be triggers for autoimmune disease. Common environmental factors include smoking (which is not recommended), viral and bacterial infections, air pollution, and more. Current thinking is that infection plays a role in the pathogenesis in Sjögren’s, and one such infection that has been associated with Sjögren’s disease is Epstein–Barr virus. Exposure to chromium has more recently been linked to an increased risk for Sjögren’s as well. Further research into these and other environmental contributors is needed to elucidate their role in Sjögren’s and to better help patients, practitioners, and researchers to better prevent, manage, and treat this complex disease.
The Internal Organs in Sjögren’s
Authors: Hal Scofield R. , Soliotis Fotini C. , Kassan Stuart S. , Moutsopoulos Haralampos M. 
Published: May 2022

Abstract
In many patients, Sjögren’s disease is largely limited to glandular disease, but some patients will have varying degrees of involvement of the internal organs, such as the heart, lung, kidney, liver, brain, and blood vessels. This involvement may be manifested in the form of pericarditis, interstitial lung disease, renal tubular acidosis, neuromyelitis optica, vasculitis, pleurisy, and complications of the lungs and the peripheral and central nervous systems—among others. To optimize management, the treating physician should be aware of the patient’s symptoms, signs, and physical findings and the relative frequency of these manifestations. Many other autoimmune syndromes coexist with Sjögren’s disease as well.