bluuebunny/crossref_metadata_2025_split huggingface dataset:
Existence of Hölder Continuous Solutions for a Class of Degenerate Fourth-Order Elliptic Equations
Authors: Cirmi G. R. , D’Asero S. , Leonardi S. 
Published: June 2022

AbstractThis paper deals with the existence of bounded and locally Hölder continuous weak solutions of a homogeneous Dirichlet problem related to a class of nonlinear fourth-order elliptic equations with strengthened degenerate ellipticity condition.
„Deprescribing“ von Antipsychotika bei Demenz
Authors: Roßmeier Carola , Gast Jennifer , Riedl Lina , Hartmann Julia , Kohl Sarah , Hartmann Florentine , Diehl-Schmid Janine 
Published: June 2022

Zusammenfassung
Hintergrund
In Leitlinien zur Behandlung von psychischen und Verhaltenssymptomen bei Demenz („Behavioral and Psychological Symptoms of Dementia“ [BPSD]) wird empfohlen, Antipsychotika im Falle einer notwendigen Therapie zeitlich begrenzt und in möglichst geringer Dosis einzusetzen.

Fragestellung
Um das Bewusstsein für die Risiken einer Antipsychotikabehandlung bei Patient:innen mit Demenz und die dadurch begründete Notwendigkeit einer zeitlich begrenzten und möglichst niedrig dosierten Antipsychotikabehandlung zu schärfen, wurden Handlungsempfehlungen zum Deprescribing von Antipsychotika bei Menschen mit Demenz entwickelt.

Material und Methoden
Die Entwicklung der Handlungsempfehlungen erfolgte in einem mehrstufigen Prozess: 1. Literaturrecherche unter besonderer Würdigung von konsentierten Leitlinienempfehlungen und Ergebnissen einer eigenen Interventionsstudie (READY-Studie), 2. Diskussion und Konsentierung in einem Expert:innengremium, 3. Onlineumfrage von in Deutschland tätigen ärztlichen Demenzexpert:innen.

Ergebnisse
Aus 51 im ersten Entwurf zusammengestellten Aussagen wurden nach der Diskussion im multiprofessionellen Expert:innengremium 32 Aussagen zum „Deprescribing“ (Reduktion und Ausschleichen) von Antipsychotika formuliert. 25 der 32 Aussagen wurden nach Konsentierung in einer Onlineumfrage durch ärztliche Demenzexpert:innen final übernommen.

Diskussion
In Deutschland gibt es bislang keine konkreten Empfehlungen zur Vorgehensweise bei Reduktion und Absetzen von Antipsychotika, die zur Behandlung von BPSD bei Menschen mit Demenz eingesetzt werden. Die vorgelegte Arbeit soll als Handlungsempfehlung für Haus- und Fachärzt:innen dienen. Bei den Empfehlungen handelt es sich um keine Leitlinien, sie ersetzen nicht die Eigenverantwortlichkeit der Behandelnden und das individuell notwendige Vorgehen in Abhängigkeit von der Behandlungssituation.
The Lagrangian, constraint qualifications and economics
Authors: Flåm Sjur D. , Rückmann Jan-J. 
Published: June 2022

AbstractConsidering constrained choice, practitioners and theorists frequently invoke a Lagrangian to generate optimality conditions. Regular use of that vehicle requires, however, some constraintqualification. Yet many economists go easy on the mathematics of that issue. Conversely, few mathematicians elaborate on the economics of the context. Thereby both parties leave some lacunas as to didactics or intuition. This note attempts to shed some light on these matters.
The Effect of Anti-rheumatic Drugs on the Skeleton
Authors: Hauser B. , Raterman H. , Ralston S. H. , Lems W. F. 
Published: June 2022

AbstractThe therapeutic armamentarium for rheumatoid arthritis has increased substantially over the last 20 years. Historically antirheumatic treatment was started late in the disease course and frequently included prolonged high-dose glucocorticoid treatment which was associated with accelerated generalised bone loss and increased vertebral and non-vertebral fracture risk. Newer biologic and targeted synthetic treatments and a combination of conventional synthetic DMARDs prevent accelerated systemic bone loss and may even allow repair of cortical bone erosions. Emerging data also gives new insight on the impact of long-term conventional synthetic DMARDs on bone health and fracture risk and highlights the need for ongoing studies for better understanding of “established therapeutics”. An interesting new antirheumatic treatment effect is the potential of erosion repair with the use of biologic DMARDs and janus kinase inhibitors. Although several newer anti-rheumatic drugs seem to have favorable effects on bone mineral density in RA patients, these effects are modest and do not seem to influence the fracture risk thus far. We summarize recent developments and findings of the impact of anti-rheumatic treatments on localized and systemic bone integrity and health.
Microbial ecology of biofiltration used for producing safe drinking water
Authors: Bai Xi , Dinkla Inez J. T. , Muyzer Gerard 
Published: June 2022

Abstract

Biofiltration is a water purification technology playing a pivotal role in producing safe drinking water. This technology attracts many interests worldwide due to its advantages, such as no addition of chemicals, a low energy input, and a high removal efficiency of organic compounds, undesirable taste and odours, and pathogens. The current review describes the microbial ecology of three biofiltration processes that are routinely used in drinking water treatment plants, i.e. (i) rapid sand filtration (RSF), (ii) granular activated carbon filtration (GACF), and (iii) slow sand filtration (SSF). We summarised and compared the characteristics, removal performance, and corresponding (newly revealed) mechanisms of the three biofiltration processes. Specifically, the microbial ecology of the different biofilter processes and the role of microbial communities in removing nutrients, organic compounds, and pathogens were reviewed. Finally, we highlight the limitations and challenges in the study of biofiltration in drinking water production, and propose future perspectives for obtaining a comprehensive understanding of the microbial ecology of biofiltration, which is needed to promote and optimise its further application.

Key points
• Biofilters are composed of complex microbiomes, primarily shaped by water quality.
• Conventional biofilters contribute to address safety challenges in drinking water.
• Studies may underestimate the active/functional role of microbiomes in biofilters.
Estimates of Treatable Deaths Within the First 20 Years of Life from Scaling Up Surgical Care at First‐Level Hospitals in Low‐ and Middle‐Income Countries
Authors: Sykes Alicia G. , Seyi‐Olajide Justina , Ameh Emmanuel A. , Ozgediz Doruk , Abbas Alizeh , Abib Simone , Ademuyiwa Adesoji , Ali Abdelbasit , Aziz Tasmiah Tahera , Chowdhury Tanvir Kabir , Abdelhafeez Hafeez , Ignacio Romeo C. , Keller Benjamin , Klazura Greg , Kling Karen , Martin Benjamin , Philipo Godfrey Sama , Thangarajah Hariharan , Yap Ava , Meara John G. , Bundy Donald A. P. , Jamison Dean T. , Mock Charles N. , Bickler Stephen W. ,   the Global Initiative for Children's Surgery
Published: June 2022

AbstractBackgroundSurgical care is an important, yet often neglected component of child health in low‐ and middle‐income countries (LMICs). This study examines the potential impact of scaling up surgical care at first‐level hospitals in LMICs within the first 20 years of life.MethodsEpidemiological data from the global burden of disease 2019 Study and a counterfactual method developed for the disease control priorities; 3rd Edition were used to estimate the number of treatable deaths in the under 20 year age group if surgical care could be scaled up at first‐level hospitals. Our model included three digestive diseases, four maternal and neonatal conditions, and seven common traumatic injuries.ResultsAn estimated 314,609 (95% UI, 239,619–402,005) deaths per year in the under 20 year age group could be averted if surgical care were scaled up at first‐level hospitals in LMICs. Most of the treatable deaths are in the under‐5 year age group (80.9%) and relates to improved obstetrical care and its effect on reducing neonatal encephalopathy due to birth asphyxia and trauma. Injuries are the leading cause of treatable deaths after age 5 years. Sixty‐one percent of the treatable deaths occur in lower middle‐income countries. Overall, scaling up surgical care at first‐level hospitals could avert 5·1% of the total deaths in children and adolescents under 20 years of age in LMICs per year.ConclusionsImproving the capacity of surgical services at first‐level hospitals in LMICs has the potential to avert many deaths within the first 20 years of life.
Laparoscopic appendectomy for complicated appendicitis in children: does the post-operative peritoneal drain make any difference? A pilot prospective randomised controlled trial
Authors: Human M. J. , Tshifularo N. , Mabitsela M. 
Published: June 2022

Abstract
Purpose
This was a pilot randomised, prospective study, which aimed to determine and compare the post-operative complications of paediatric patients undergoing laparoscopic appendectomy (LA) for complicated appendicitis, with and without a peritoneal drain.

Methods
Patients younger than 13 years, undergoing LA for complicated appendicitis at the Dr George Mukhari Academic Hospital (DGMAH), over a 15-month period during 2019–2020 were enrolled. Randomisation was achieved by a blocked randomisation plan. Patients were randomised in a 1:1 ratio into the “drain” (D) and “no drain” (ND) groups.

Results
Thirty-four patients were included in this study; seventeen in each group. The complication rate was 26%. Intra-abdominal collection accounted for 89% of the complications. The complication rate in the “D” group was 18% and 35% in the “ND” group, with no statistically significant difference. Complication rates were higher (38%) in patients with generalised pus when compared to localised pus (7%), although not statistically significant. The mean theatre time, hospital stay, and duration of antibiotic use did not differ significantly between the groups.

Conclusion
From our study, the post-operative peritoneal drain did not make any statistically significant difference in patient outcome. The amount of intra-abdominal contamination is more likely to contribute in the development of complications.

Trial registration number
SMUREC/M/15/2019: PG.
Fat embolism after intraosseous catheters in pediatric forensic autopsies
Authors: Castiglioni C. , Carminati A. , Fracasso T. 
Published: June 2022

AbstractIn our center, we performed the autopsy of a child who died from drowning and presented, at autopsy, a major pulmonary fat embolism (PFE). A cardiopulmonary resuscitation (CPR) was performed, including infusion by intraosseous catheter (IIC). No other traumatic lesions and diseases classically related to a risk of PFE were detected. According to some animal studies, we considered the IIC as the only possible cause for PFE. However, we could not find literature to confirm this hypothesis in humans, especially in a pediatric population. To verify the occurrence of PFE after IIC in a pediatric population, we retrospectively selected 20 cases of pediatric deaths autopsied in our center, in which a CPR was performed, without bone fractures or other possible causes of PFE: 13 cases with IIC (group A) and 7 cases without IIC (group B). Several exclusion criteria were considered. The histology slides of the pulmonary tissue were stained by Oil Red O. PFE was classified according to the Falzi scoring system. In group A, 8 cases showed PFE: 4 cases with a score 1 of Falzi and 4 cases with a score 2 of Falzi. In group B, no case showed PFE. The difference between the two groups was statistically significant. The results of our study seem to confirm that IIC can lead to PFE in a pediatric population and show that the PFE after IIC can be important (up to score 2 of Falzi). To the best of our knowledge, our study is the first specifically focused on the occurrence of PFE after IIC in a pediatric population by using autoptic data.
Potential role of passively increased muscle temperature on contractile function
Authors: Rodrigues Patrick , Trajano Gabriel S. , Stewart Ian B. , Minett Geoffrey M. 
Published: June 2022

AbstractDeclines in muscle force, power, and contractile function can be observed in older adults, clinical populations, inactive individuals, and injured athletes. Passive heating exposure (e.g., hot baths, sauna, or heated garments) has been used for health purposes, including skeletal muscle treatment. An acute increase in muscle temperature by passive heating can increase the voluntary rate of force development and electrically evoked contraction properties (i.e., time to peak twitch torque, half-relation time, and electromechanical delay). The improvements in the rate of force development and evoked contraction assessments with increased muscle temperature after passive heating reveal peripheral mechanisms’ potential role in enhancing muscle contraction. This review aimed to summarise, discuss, and highlight the potential role of an acute passive heating stimulus on skeletal muscle cells to improve contractile function. These mechanisms include increased calcium kinetics (release/reuptake), calcium sensitivity, and increased intramuscular fluid.
Re-interpreting mesenteric vascular anatomy on 3D virtual and/or physical models, part II: anatomy of relevance to surgeons operating splenic flexure cancer
Authors: Andersen Bjarte Tidemann , Stimec Bojan V. , Kazaryan Airazat M. , Rancinger Peter , Edwin Bjørn , Ignjatovic Dejan 
Published: June 2022

AbstractBackgroundThe splenic flexure is irrigated from two vascular areas, both from the middle colic and the left colic artery. The challenge for the surgeon is to connect these two vascular areas in an oncological safe procedure.Materials and methodsThe vascular anatomy, manually 3D reconstructed from 32 preoperative high-resolution CT datasets using Osirix MD, Mimics Medical and 3-matic Medical Datasets, were exported as STL-files, video clips, stills and supplemented with 3D printed models.ResultsOur first major finding was the difference in level between the middle colic and the inferior mesenteric artery origins. We have named this relationship a mesenteric inter-arterial stair. The middle colic artery origin could be found cranial (median 3.38 cm) or caudal (median 0.58 cm) to the inferior mesenteric artery. The lateral distance between the two origins was 2.63 cm (median), and the straight distance 4.23 cm (median). The second finding was the different trajectories and confluence pattern of the inferior mesenteric vein. This vein ended in the superior mesenteric/jejunal vein (21 patients) or in the splenic vein (11 patients). The inferior mesenteric vein confluence could be infrapancreatic (17 patients), infrapancreatic with retropancreatic arch (7 patients) or retropancreatic (8 patients). Lastly, the accessory middle colic artery was present in ten patients presenting another pathway for lymphatic dissemination.ConclusionThe IMV trajectory when accessible, is the solution to the mesenteric inter-arterial stair. The surgeon could safely follow the IMV to its confluence. When the IMV trajectory is not accessible, the surgeon could follow the caudal border of the pancreas.Graphical abstract
High critical currents for dendrite penetration and voiding in potassium metal anode solid-state batteries
Authors: Spencer Jolly Dominic , Perera Johann , Pu Shengda D. , Melvin Dominic L. R. , Adamson Paul , Bruce Peter G. 
Published: June 2022

AbstractPotassium metal anode solid-state cells with a K-beta”-alumina ceramic electrolyte are found to have relatively high critical currents for dendrite penetration on charge of approximately 4.8 mA/cm2, and voiding on discharge of approximately 2.0 mA/cm2, at 20 °C under 2.5 MPa stack-pressure. These values are higher than generally reported in the literature under comparable conditions for Li and Na metal anode solid-state batteries. The higher values for potassium are attributed to its lower yield strength and its readiness to creep under relatively low stack-pressures. The high critical currents of potassium anode solid-state batteries help to confirm the importance of the metal anode mechanical properties in the mechanisms of dendrite penetration and voiding.
Metaheuristic-based support vector regression for landslide displacement prediction: a comparative study
Authors: Ma Junwei , Xia Ding , Guo Haixiang , Wang Yankun , Niu Xiaoxu , Liu Zhiyang , Jiang Sheng 
Published: June 2022

AbstractRecently, integrated machine learning (ML) metaheuristic algorithms, such as the artificial bee colony (ABC) algorithm, genetic algorithm (GA), gray wolf optimization (GWO) algorithm, particle swarm optimization (PSO) algorithm, and water cycle algorithm (WCA), have become predominant approaches for landslide displacement prediction. However, these algorithms suffer from poor reproducibility across replicate cases. In this study, a hybrid approach integrating k-fold cross validation (CV), metaheuristic support vector regression (SVR), and the nonparametric Friedman test is proposed to enhance reproducibility. The five previously mentioned metaheuristics were compared in terms of accuracy, computational time, robustness, and convergence. The results obtained for the Shuping and Baishuihe landslides demonstrate that the hybrid approach can be utilized to determine the optimum hyperparameters and present statistical significance, thus enhancing accuracy and reliability in ML-based prediction. Significant differences were observed among the five metaheuristics. Based on the Friedman test, which was performed on the root mean square error (RMSE), Kling-Gupta efficiency (KGE), and computational time, PSO is recommended for hyperparameter tuning for SVR-based displacement prediction due to its ability to maintain a balance between precision, computational time, and robustness. The nonparametric Friedman test is promising for presenting statistical significance, thus enhancing reproducibility.
Coronavirus and Paramyxovirus Shedding by Bats in a Cave and Buildings in Ethiopia
Authors: Lane Jennifer K. , Negash Yohannes , Randhawa Nistara , Kebede Nigatu , Wells Heather , Ayalew Girma , Anthony Simon J. , Smith Brett , Goldstein Tracey , Kassa Tesfu , Mazet Jonna A. K. , Consortium PREDICT , Smith Woutrina A. 
Published: June 2022

AbstractBats are important hosts of zoonotic viruses with pandemic potential, including filoviruses, MERS-Coronavirus (CoV), SARS-CoV -1, and likely SARS-CoV-2. Viral infection and transmission among wildlife are dependent on a combination of factors that include host ecology and immunology, life history traits, roosting habitats, biogeography, and external stressors. Between 2016 and 2018, four species of insectivorous bats from a readily accessed roadside cave and buildings in Ethiopia were sampled and tested for viruses using consensus PCR assays for five viral families/genera. Previously identified and novel coronaviruses and paramyxoviruses were identified in 99 of the 589 sampled bats. Bats sampled from the cave site were more likely to test positive for a CoV than bats sampled from buildings; viral shedding was more common in the wet season; and rectal swabs were the most common sample type to test positive. A previously undescribed alphacoronavirus was detected in two bat species from different taxonomic families, sampling interfaces, geographic locations, and years. These findings expand knowledge of the range and diversity of coronaviruses and paramyxoviruses in insectivorous bats in Ethiopia and reinforce that an improved understanding of viral diversity and species-specific shedding dynamics is important for designing informed zoonotic disease surveillance and spillover risk reduction efforts.
G-invariant spin structures on spheres
Authors: Daura Serrano Jordi , Kohn Michael , Lawn Marie-Amélie 
Published: June 2022

AbstractWe examine which of the compact connected Lie groups that act transitively on spheres of different dimensions leave the unique spin structure of the sphere invariant. We study the notion of invariance of a spin structure and prove this classification in two different ways; through examining the differential of the actions and through representation theory.
An overview of mixing augmentation methods and augmentation strategies
Authors: Lewy Dominik , Mańdziuk Jacek 
Published: June 2022

AbstractDeep Convolutional Neural Networks have made an incredible progress in many Computer Vision tasks. This progress, however, often relies on the availability of large amounts of the training data, required to prevent over-fitting, which in many domains entails significant cost of manual data labeling. An alternative approach is application of data augmentation (DA) techniques that aim at model regularization by creating additional observations from the available ones. This survey focuses on two DA research streams: image mixing and automated selection of augmentation strategies. First, the presented methods are briefly described, and then qualitatively compared with respect to their key characteristics. Various quantitative comparisons are also included based on the results reported in recent DA literature. This review mainly covers the methods published in the materials of top-tier conferences and in leading journals in the years 2017–2021.
VPint: value propagation-based spatial interpolation
Authors: Arp Laurens , Baratchi Mitra , Hoos Holger 
Published: June 2022

AbstractGiven the common problem of missing data in real-world applications from various fields, such as remote sensing, ecology and meteorology, the interpolation of missing spatial and spatio-temporal data can be of tremendous value. Existing methods for spatial interpolation, most notably Gaussian processes and spatial autoregressive models, tend to suffer from (a) a trade-off between modelling local or global spatial interaction, (b) the assumption there is only one possible path between two points, and (c) the assumption of homogeneity of intermediate locations between points. Addressing these issues, we propose a value propagation-based spatial interpolation method called VPint, inspired by Markov reward processes (MRPs), and introduce two variants thereof: (i) a static discount (SD-MRP) and (ii) a data-driven weight prediction (WP-MRP) variant. Both these interpolation variants operate locally, while implicitly accounting for global spatial relationships in the entire system through recursion. We evaluated our proposed methods by comparing the mean absolute error, root mean squared error, peak signal-to-noise ratio and structural similarity of interpolated grid cells to those of 8 common baselines. Our analysis involved detailed experiments on a synthetic and two real-world datasets, as well as experiments on convergence and scalability. Empirical results demonstrate the competitive advantage of VPint on randomly missing data, where it performed better than baselines in terms of mean absolute error and structural similarity, as well as spatially clustered missing data, where it performed best on 2 out of 3 datasets.