bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical synergistic antitumor efficacy of Lienal Polypeptide combined with EGFR-TKIs for advanced NSCLC
Authors: Chen Yun , Liu Xinyin , Yao Jiaqi , Jin Shidai , Li Jun , Xu Jiali , Guo Renhua 
Published: April 2022

Abstract
Purpose: EGFR-TKIs are the first-line therapy for advanced NSCLC harboring EGFR-sensitive mutations. A robust immunity is an essential foundation for patients to tolerate continuous drug treatments. Lienal polypeptide (LP) is an immunomodulator widely applied to regulate immunity in clinical practice. Nevertheless, its potential impact on EGFR-TKIs therapy has not been illustrated. This study aimed to explore the immunomodulatory and antitumor efficacy of LP in combination with EGFR-TKIs threapy in advanced NSCLC.Patients and methods: Retrospective analysis on variation of lymphocytes in 106 NSCLC patients after EGFR-TKIs combined with LP treatment was performed. Proliferation experiment, transwell and wound healing assays were performed in PC9-GR cells to estimate influence of LP on tumor proliferation, invasion and migrati n in vitro . Flow cytometry was performed to detect cell apoptosis and cell cycle. The expression of p-EGFR and EGFR were detected by Western blot to investigate antitumor effect of LP.Results: The levels of CD3 + , CD4 + T cells and the CD4 + /CD8 + ratio were higher in NSCLC patients treated with Gefitinib in conjunction with LP. Gefitinib combined with LP inhibited tumor invasion and migration, triggered G0/G1 phase arrest to block cellular proliferation and promote cell apoptosis in vitro. Furthermore, the expression of p-EGFR was decreased after Gefitinib-combining-LP treatment.Conclusions: LP had a synergistic anticancer effect with EGFR-TKIs in NSCLC. LP in combination with EGFR-TKIs therapy has clinical curative effect in treatment of advanced NSCLC with EGFR driving mutations, can effectively enhance physical immunity and resensitize drug-resistant cells to EGFR-TKIs, which has a certain clinical application value.
Community-based household survey to identify disability burden and health-related quality of life following road traffic accidents in Ujjain, India
Authors: Pathak Ashish , Mathur Aditya , Mehra Love , Pathak Deepali 
Published: April 2022

Abstract
BackgroundThe objective of the study was to report the health-related quality of life (HRQOL) following road traffic accidents (RTAs) among children. MethodsA community-based survey using EuroQol five-dimension questionnaire (EQ-5D-5L) in Hindi was used to collected data from community. The survey included 2620 households from urban and rural areas of Ujjain, India. ResultsFrom the 2620 households included in the study, 229 children aged 5–18 years with a history of RTA in the last 1 year were identified, with 27%, 63%, and 10% children reporting mild, moderate, and severe injury based on length of hospitalization. Motorcycles, bicycles, and pedestrians constituted most RTAs. Helmet use was low (12%). EQ-5D-5L revealed that the most severe and extreme problem post RTA in children was pain and discomfort, whereas the least severe problem was usual activity and self-care. The most common (65%) injuries were either abrasion or fracture and dislocation. EQ-5D-5L severity index was maximum (mean 72) for lower extremity injuries. ConclusionsThe results of the present study highlight the ability and requirement for quality-of-life measurement using EQ-5D-5L among children post-RTA.
Consensus Guideline on the Management of Epilepsy in Egypt: A National Delphi Consensus Study
Authors: Kishk Nirmeen , Hosny Hassan , Badry Reda , Elmenshawi Ibrahim , Hamdy Mohamed M. , Shaker Ehab , Shehata Hatem S. , Magdy Rehab , Ramzy Gihan M. , Hemeda Mahmoud , Gaber Ahmed , Abdelhamed Mohamed , Abohagar Ahmed , Yassine Imane A , Abbas Mohammed , Shaheen Hala A. , Moety Mahmoud Abdel , Metwally Hussein M H , Saeed Mohammad Ali , Essmat Ahmed , Abdou Ashraf , Soliman Rasha Hassan , Oraby Mohammed I. , Morad Abd El-Naser , Kasem Shaimaa Mohammed , Aidaros Magdy , Heneedy Yasser El , ElNemr Ahmed , Elkady Ahmed , Amin Ramy , Ghany Walid A. Abdel , Morsy Ahmed A. , Shamloul Reham 
Published: April 2022

Abstract
In epilepsy, early diagnosis, accurate determination of epilepsy type, proper selection of anti-seizure treatment, and monitoring; all are essential. However, despite recent therapeutic advances and conceptual reconsiderations in the classification and management of epilepsy, serious gaps are still encountered in day-to-day practice in Egypt as well as several other limited resources countries. Premature mortality, poor quality of life, disabilities, diminished family function, cognitive problems, poor treatment outcomes, comorbidities, and significant economic burden are major challenges that impose urgent actions to be implemented at all levels. In recognition of this, a group of Egyptian epilepsy experts met through a series of consecutive meetings to specify main concepts and questions concerning the diagnosis, evaluation, and management of Epilepsy, with an ultimate goal of establishing a nationwide Egyptian consensus to guide health care professionals in the management of patients with epilepsy in general and to declare a pragmatic pathway for patients with drug-resistant epilepsy. The consensus was developed through a modified Delphi methodology. A thorough review of the most recent relevant literature and international guidelines was performed to evaluate their applicability to the Egyptian situation. Afterward, several remote and live rounds were scheduled to reach a final agreement for all listed statements. With the implementation of these unified recommendations, we believe this will bring about substantial improvements in both the quality of care and treatment outcomes for persons with epilepsy in Egypt.
A National Study of Pregnancy Related Maternal and Fetal Outcomes in Women with Inflammatory Bowel Disease.
Authors: Tarar Zahid Ijaz , Farooq Umer , Zafar Muhammad Usman , Saleem Saad , Nawaz Ahmed , Kamal Faisal , Ghous Ghulam , Inayat Faisal , Ghouri Yezaz A. 
Published: April 2022

Abstract
Background and Aims:The incidence of Inflammatory bowel disease (IBD) among women is highest during their reproductive years and current estimates suggest that rate of conception is low in female IBD patients. The aim of our study was to assess the burden of adverse maternal and perinatal outcomes among female IBD patients.Methods:Using the national inpatient sample database from 2016 to 2018 we extracted data of all female patients above the age of 15 years admitted with a primary diagnosis of pregnancy and a secondary diagnosis of ulcerative colitis or Crohn’s disease. Multivariable regression analysis was performed to determine the effect of IBD on maternal and fetal outcomes.Results:Pregnant women with IBD had greater odds of gestational diabetes (AOR 1.55, 95% CI 1.04-2.3, p= 0.02), hypertensive complications (adjusted odds ratio [AOR] 1.35, 95% CI 1.06-1.72, p= 0.01) and pre-term delivery (AOR, 1.41 95% CI 1.13-1.76, p= 0.003). Pregnancies with co-existent IBD were associated with fetal growth restriction (AOR 1.27, 95%CI 1-1.63, p= 0.04) and fetal death (AOR 3.21, 95% CI 1.72-6.00, p <0.01). Odds of experiencing postpartum hemorrhage or delivering large for gestational age infant were the same in IBD and general population.Conclusions:Women with IBD were associated with worse maternal and fetal outcomes as well higher resource utilization. We suggest that women who have moderate to severe disease should get pre-conceptional counselling and undergo appropriate treatment to achieve remission. This may reduce the fear associated with conception and decrease risk of maternal and fetal complications.
Hounsfield unit attenuation value can distinguish pyonephrosis from hydronephrosis in parents with upper urinary tract stones
Authors: Lu Xiaofei , Ding Yanting , Hu Dechao , Zhou benzheng 
Published: April 2022

Abstract
Objective: To evaluate the attenuation value [Hounsfield unit (HU)] in non-contrast CT for distinguishing pyonephrosis from hydronephrosis in parents with upper urinary tract (UTS) stones and to identify factors predicting the development of sepsis in patients with pyonephrosis. Methods: Between October 2019 and October 2021, patients with hydronephrosis or pyonephrosis secondary to upper urinary tract stones (UTS) were retrospectively searched in our study. All patients with UTS were treated with either percutaneous nephrostomy (PCN) or surgical management (percutaneous nephrolithotomy / transurethral ureteroscope lithotripsy). We excluded patients treated with extracorporeal shock-wave lithotripsy or patients with bilateral upper urinary tract stones. Patients whose CT was not performed in our hospital or treated in another hospital were also excluded. Clinical data regarding basic information, clinical feature, co-morbidities, previous intervention, infection-related indicators, Calculi-related indicators, HU values of the renal pelvis, the thick wall of the renal pelvis on CT were collected. Univariate and multivariate logistic analyses were performed. ROC curves were drawn to predict pyonephrosis and sepsis. Results: Two-hundred-forty patients with UTS were included in our study, 191 patients had hydronephrosis without pyonephrosis (Group 1), and 49 patients had hydronephrosis with pyonephrosis (Group 2). The HU value of the renal collecting system in Group 2 (mean, 15.46; range, +1/+30) was significantly higher than that in Group 1 (mean, 5.5;5 range -6/+24) (P = 0.02); the ROC curve analysis revealed that the HU value (AUC = 0.613) of 9.5 was the best cut-off value to predict calculi-related obstructive pyonephrosis, with 71.4% sensitivity and 70.2% specificity. But it cannot predict the development of sepsis in patients with postoperative pyonephrosis (p = 0.11). Multivariate analysis showed that age (P = 0.041), sex (p = 0.036), herpes labialis (p = 0.018), and serum albumin (p = 0.027) were significant predictors for the development of sepsis in patients with postoperative pyonephrosis. Conclusions: The HU attenuation value of the renal collecting system can distinguish pyonephrosis from hydronephrosis, but it cannot predict sepsis in patients with pyonephrosis postoperative. Older, low-serum albumin female patients with renal pyonephrosis caused by UUT stones are more likely to develop urogenic sepsis.
Disinfection effect of hexadecyl pyridinium chloride on SARS-CoV-2 in vitro
Authors: Chen Keda , Ma Feike , Wang Ying , Zhuang Xinyi , Zhang Xuning , Mao Haiyan , Zhang Yanjun 
Published: April 2022

Abstract
The novel coronavirus (COVID-19 or 2019-nCoV) is a respiratory virus that can exist in the mouth and saliva of patients and spreads through aerosol dispersion. Therefore, stomatological hospitals and departments have become high-infection-risk environments. Accordingly, the search for oral disinfectants that can effectively inactivate the virus has become a highly active area of research. Hexadecyl pyridinium chloride, povidone-iodine, and other common oral disinfectants are the natural primary choices for stomatological hospitals. Therefore, this study investigated the inhibitory effect of hexadecyl pyridinium chloride on SARS-CoV-2 in vitro. Vero cells infected with SARS-CoV-2 were used to determine disinfection effect; the CCK-8 method was used to determine cytotoxicity; and viral load was determined by real-time PCR. The results showed that hexadecyl pyridinium chloride has no obvious cytotoxic effect on Vero cells in the concentration range 0.0125–0.05 mg/mL. The in vitro experiments showed that hexadecyl pyridinium chloride significantly inhibits the virus at concentrations of 0.1 mg/mL or above at 2 min of action. Thus, the results provide experimental support for the use of hexadecyl pyridinium chloride in stomatological hospitals.
Cut surface biliary complications in open and laparoscopic liver resections
Authors: Sucher Robert , Recknagel Sebastian , Guice Hanna , Sucher Elisabeth , Lederer Andri , Berg Thomas , Höhne Claudia , Scheuermann Uwe , Seehofer Daniel 
Published: April 2022

Abstract
Background/AimsAim of our study was to analyze surgical parameters and postoperative morbidity with special emphasis on cut surface biliary leakage (BL), after launching a minimally invasive liver resection program at our center.Patients and methodsA prospectively maintained medical database of patients who required liver resection was used for analysis. Exclusion criteria were liver resections with biliodigestive anastomosis. Clinicopathological characteristics and outcomes were analyzed retrospectively.ResultsA total of 141 patients were divided into a group of 47 patients (33.3%) receiving laparoscopic (LLR) and 94 patients (66.7%) undergoing open liver resections (OLR). We performed 62 major OLR (66.0%) and 31 major LLR (66.0%). In comparison with the LLR group, operation time was longer (326 ± 97 minutes vs. 287 ± 133 minutes; P = 0.080) and average blood loss was higher in the OLR group (529 ± 441 mL vs. 356 ± 459 mL; P = 0.052), without showing significancy. In the LLR group, morbidity was significantly lower than in the OLR group (OLR vs. LLR: 19 (20.2 %) vs. 3 (6.4%); P = 0.033). Overall BL rate was 4.3% (N = 6). All BL occurred in patients after OLR and were associated with a significantly longer hospital stay (hospital stay with biliary leakage vs. hospital stay without biliary leakage: 37.3 ± 19.3 days vs. 14.7 ± 11.1 days; P < 0.001).ConclusionThe introduction of different transection techniques in laparoscopic liver resections did not increase morbidity and BL rate.
PENGARUH INFLASI PADA SUKU BUNGA BANK INDONESIA PERIODE 2005-2015
Authors: Abidin Zainal 
Published: April 2022

Abstrak: inflasi merupakan peristiwa ekonomi yang sering terjadi di berbagai negara baik negara berkembang maupun negara maju, inflasi ditandai dengan naiknya harga barang dan jasa yang berdampak menurunnya nilai mata uang suatu negara sehingga dapat mengakibatkan menurunnya daya beli konsumen pada akhirnya juga memepengaruhi pendapatan nasional. Pemerintah mengatasi inflasi melalui beberapa kebijakan salah satunya kebijakan moneter dengan menaikkan atau menurunkan suku bunga BI. Metode penelitian yang digunakan pada penelitian ini menggunakan pendekatan kuantitatif sedangkan sumber data berupa data sekunder. Data sekunder yang digunakan yaitu data inflasi dan suku bunga BI peroide Juli 2005-Desember 2015 dengan menggunakan metode analisis regresi linier sederhana menggunakan program SPSS versi 18.0. Hasil penelitian diperoleh bahwa variabel inflasi memiliki pengaruh terhadap variabel suku bunga BI yang ditunjukkan melalui nilai ttabel < thitung (1,65714 < 18,657) dan taraf signifikansi yang kuat sebesar 0,05. Persamaan regresi menunjukkan arah positif sehingga jika inflasi meningkat maka suku bunga juga meningkat. Variasi suku bunga dapat diterangkan oleh variasi inflasi sebesar 0,737% dan 0,263 dijelaskan oleh variable selain inflasi seperti investasi, tingkat peredaran uang di masyarakat dan valuta asing.
Cation ordering, twinning, and pseudo-symmetry in silicate garnet: The study of a birefringent garnet with orthorhombic structure
Authors: Xu Huifang , Jin Shiyun , Lee Seungyeol , Brown Philip E. 
Published: April 2022

AbstractThe crystal structure of a birefringent garnet (~Adr53Grs47) that occurs as a late-stage rim on andradite from Stanley Butte, Graham County, Arizona is analyzed and refined using single-crystal XRD. The structure has an orthorhombic I 2/a 1 2/d (unconventional setting for Fddd) space group symmetry, with unit-cell parameters of a = b = 11.966(3) Å, c = 11.964(3) Å, α = β = 90°, γ = 90.29(2)°, V = 1713.0(7) Å3, Z = 8. The orthorhombic garnet displays very high birefringence (δ ~0.021) produced by the strong Fe-Al ordering in the octahedral sites, with Fe occupancies of 0.804 and 0.221 in Y1 and Y2 sites, respectively. Diffraction peaks (such as 101 and 103) violating the Ia3d symmetry of cubic garnet are obvious even in powder XRD pattern. The homogenization temperatures of the fluid inclusions suggest that the low-crystallization temperature is responsible for the ordered orthorhombic structure. The strong ordering state of the structure and the sharp boundaries in the chemical zoning in the crystal (between ~Adr53Grs47 and ~Adr100) indicate the orthorhombic intermediate grandite garnet is a thermodynamically stable phase at low temperature, separated by wide miscibility gaps from the pure end-members (grossular and andradite) with cubic structures. Most of the previously reported triclinic garnet structures are likely artifacts produced by pseudo-merohedral twinning of less-ordered orthorhombic structure, as indicated by the characteristic pairing pattern of different Y-sites with the same occupancies.
Quantum Dots as Theranostic Agents: Recent Advancements, Surface
Modifications, and Future Applications
Authors: Phafat Bhushan , Bhattacharya Sankha 
Published: April 2022

Abstract:
The use of quantum technology to deliver drugs has the potential to increase the efficacy
of many rare disease treatments. Semiconductor nanoparticles are a new type of treatment for
life-threatening disorders. The term "quantum dots" refers to semiconductor nanoparticles. These
quantum dots have a one-of-a-kind shape, size, fluorescence characteristics, and shape-dependent
optoelectronic capacities. As a result, we believe that quantum dots (QDs) has the potential to be
destined as medication carriers, biosensors, etc. Due to improvements in research, medicinal, and
clinical domains, an in-depth examination of quantum dots is now possible. Quantum dots are also
classed as carbon-based quantum dots, graphene-based quantum dots, and cadmium-based quantum
dots, with variations in their main structure, leading to the discovery of more comparable and
diversified quantum dots. Semiconductor quantum dots, or QDs, have also made tremendous progress
in the field of fluorescence bioimaging research. After examining their in-vitro and in-vivo
applications, we may currently use QDs as agents for gene transport, medication delivery, and enhancing
the biocompatibility of other medications. This article discusses the significant breakthroughs
and challenges in the field of quantum dots as biosensors for bioimaging, surface changes,
quantum dots in the treatment of numerous diseases, and future features of quantum dots and
their improvements in biomedical applications.
Vitamin K as a Simple but Efficient Add-on to the Current Treatment
Regime of COVID-19: A Narrative Review
Authors: Sreelatha Souparnika , Devang Nayana , Marathe Aradhana 
Published: April 2022

Background:
Intravascular thrombosis and pulmonary fibrosis in COVID-19 patients
with pneumonia are significantly associated with the severity of the disease. Vitamin K is known
to balance the coagulation mechanisms and also prevent calcification and fibrosis of the extrahepatic
soft tissues. This narrative review focuses on the role of vitamin K as a linking factor for
thrombotic as well as pulmonary complications of COVID-19.

Methods and Results:
Article search was performed in databases of WHO, PubMed, Scopus and
Clinical Trial Registry using appropriate keywords. Original articles included very few observational
studies which showed a reduced level of vitamin K as well as activated extrahepatic vitamin
K Dependent Proteins (VKDP) in COVID-19 patients when compared to healthy controls.
Chronic treatment with vitamin K Antagonists did not reduce the risk of in-hospital death. Docking
study was performed using Swiss dock, and it demonstrated a significant interaction between
menaquinone and SARS-CoV-2 main protease (SARS-CoV-2 Mpro).

Discussion:
Deficiency of vitamin K in COVID-19 can be due to excessive use of
antagonists or defective ingestion or absorption. This triggers an imbalance in the normal coagulation-
anticoagulation mechanism by channeling the available vitamin K to the liver, thereby
causing a deficiency of the same in extrahepatic tissues, thus finally leading to thrombosis. This
also prevents carboxylation and activation of extrahepatic VKDP required to prevent the calcification
of soft tissues, thus leading to lung fibrosis.

Conclutions:
Supplementation of vitamin K should be considered as a potentially modifiable risk
factor in severe COVID-19. Randomized control trials are highly recommended to provide clearer
evidence on the same.
Coagulopathy and Brain Injury Pathogenesis in Post-Covid-19 Syndrome
Authors: Marzoog Basheer Abdullah 
Published: April 2022

Abstract:
The post-COVID neurological syndrome has been coined, which describes the functional
and structural sequelae of coronavirus infection disease-19 (COVID-19) in the brain.
Mild/severe manifestations of the post-COVID neurological syndrome have been identified in
approximately 33.00% of COVID-19 survivors. The presence of neurological complications after
COVID allowed neuropathologists to investigate in-depth the role of viral infection in neurons.
The pathophysiology of the post-COVID neurological syndrome involved the development of a
systematic response, including coagulopathy characterized by the formation of microthrombi.
Coagulopathy, an old term for a new disease, describes the discrepancy between pro-coagulant
and anticoagulant systems due to overexpression of pro-coagulant substances and or their receptors
in addition to suppression of the anticoagulant molecules and or their receptors. Vascular
endothelial cells and hepatocytes play a central role in the regulation of hemostasis that is disrupted
during the acute phase response (APR) of coronavirus-19 (COVID-19). Currently, coagulopathy
and inflammation are termed together since both form a complementary system, indicated
by the elevation of inflammatory biomarkers (APR) and fibrinolysis biomarkers (Ddimer/
fibrin). The later events of the post-COVID neurological syndrome are primarily induced
by coagulopathy and direct viral tropism. Therefore, the paper introduces the hypothesis of coagulopathy
induced post-COVID neurological syndrome.