bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging Drugs for Amyotrophic Lateral Sclerosis
Authors: Boucher Michel , Mierzwinski-Urban Monika 
Published: March 2022

Horizon scan reports provide brief summaries of information regarding new and emerging health technologies. These technologies are identified through the CADTH Horizon Scanning Service as topics of potential interest to health care decision-makers in Canada. This Horizon Scan summarizes the available information regarding emerging drug therapies for the treatment of patients with amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disorder characterized by muscle weakness and wasting. ALS can be classified as sporadic (sALS), which accounts for 85% to 90% of the cases, or familial (fALS), which includes 10% to 15% of the cases.
At present, 2 drugs are available in Canada for the treatment of patients with ALS, riluzole and edaravone. These 2 drugs provide modest benefits in terms of survival and function.
Many treatments are currently in various stages of clinical development. Fasudil, ibudilast, inosine, and masitinib are drugs of interest as they have completed phase II, and some have initiated phase III, of their respective clinical development. Several other drugs are in clinical development and are briefly described in this report: AT-1501, CNM-Au8, Engensis, Pridopidine, Verdiperstat, and Zilucoplan.
Emerging drugs for ALS pertain to different drug classes. Despite different mechanisms of action, these drugs all aim at providing a neuroprotective effect that will result in slowing of disease progression, maintenance of patient functional status, and improvement in patient survival.
Of the 4 ALS drugs of interest in late-stage development, Fasudil, Ibudilast, and Inosine have completed phase II of clinical development.
The estimated completion date for phase III of clinical development for Masitinib is December 2022.
Crustal structure of the Volgo–Uralian subcraton revealed by inverse and forward gravity modelling
Authors: Ognev Igor , Ebbing Jörg , Haas Peter 
Published: March 2022

Abstract. Volgo–Uralia is a Neoarchaean easternmost part of the East
European craton. Recent seismic studies of the Volgo–Uralian region provided
new insights into the crustal structure of this area. In this study, we
combine satellite gravity and seismic data in a common workflow to perform a
complex study of Volgo–Uralian crustal structure, which is useful for further
basin analysis of the area. In this light, a new crustal model of the
Volgo–Uralian subcraton is presented from a step-wise approach: (1) inverse
gravity modelling followed by (2) 3D forward gravity modelling. First, inversion of the satellite gravity gradient data was applied to determine
the Moho depth for the area. Density contrasts between crust and mantle were
varied laterally according to the tectonic units present in the region, and
the model is constrained by the available active seismic data. The Moho discontinuity obtained from the gravity inversion was consequently
modified and complemented in order to define a complete 3D crustal model by
adding information on the sedimentary cover, upper crust, lower crust, and
lithospheric mantle layers in the process of forward gravity modelling, where
both seismic and gravity constraints were respected. The obtained model
shows crustal thickness variations from 32 to more than 55 km in certain
areas. The thinnest crust with a thickness below 40 km is found beneath the
Precaspian basin, which is covered by a thick sedimentary layer. The
thickest crust is located underneath the Ural Mountains as well as in the
centre of the Volgo–Uralian subcraton. In both areas the crustal thickness
exceeds 50 km. At the same time, initial forward gravity modelling has shown
a gravity misfit of ca. 95 mGal between the measured Bouguer gravity anomaly
and the forward calculated gravity field in the central area of the
Volgo–Uralian subcraton. This misfit was interpreted and modelled as a
high-density lower crust, which possibly represents underplated material. Our preferred crustal model of the Volgo–Uralian subcraton respects the
gravity and seismic constraints and reflects the main geological features of
the region with Moho thickening in the cratons and under the Ural Mountains
and thinning along the Palaeoproterozoic rifts, Precaspian sedimentary basin,
and Pre-Urals foredeep.
Analisis kemampuan calon guru IPA mengintegrasikan teknologi dalam pembelajaran menggunakan SAMR
Authors: Abdurrahman Dudung , Nursafitri Nursafitri 
Published: March 2022

Pembelajaran di masa pandemi Covid 19 mengharuskan guru memiliki kemampuan dalam teknologi untuk mendukung pembelajaran. Pembelajaran model ini menjadi new normal dalam pendidikan. Oleh karena itu, calon guru harus memiliki kemampuan mengintegrasikan teknologi dalam pembelajaran. Penelitian ini bertujuan untuk menganalisis kemampuan calon guru IPA dalam mengintergasikan teknologi dalam pembelajaran IPA. Metode penelitian yang digunakan adalah deskriptif. Sampel pada penelitian ini adalah mahasiswa yang mengikuti perkuliahan microteaching semster ganjil 2021/2022 sebanyak 6 orang. Pofil kemampuan Â calon guru IPA dalam mengintegrasikan teknologi diperoleh dari observasi pembelajaran yang disimulasikan. Tingkatan integrasi teknologi dalam pembelajaran dikelompokan menggunakan SAMR. Hasilnya diperoleh bahwa mahasiswa calon guru IPA dalam mengintegrasikan pembelajaran masih berada pada tingkat subtitution. Pada tingkat ini, teknologi digunakan pada pembelajaran hanya sebatas pengganti dan tidak ada peningkatan fungsional teknologi di pembelajaran.
Studi literatur: Analisis permasalahan pembelajaran kimia SMA pada materi stoikiometri
Authors: Ahmad Listia Fauziyyah 
Published: March 2022

Hingga saat ini problematika miskonsepsi dan kesulitan siswa dalam memecahkan masalah numerik pada topik stoikiometri masih terjadi. Sebagian besar fokus penelitian hanya ditujukan pada cara mengungkap miskonsepsi siswa, padahal mengidentifikasi penyebab dan memberi solusi untuk mengatasi hal tersebut tidak kalah pentingnya. Kesulitan dalam stoikiometri disebabkan kurangnya pemahaman konsep mol, ketidakmampuan menyetarakan persamaan kimia, penggunaan hubungan stoikiometri yang tidak konsisten, mengidentifikasi pereaksi pembatas, penentuan hasil teoritis, dan identifikasi zat yang berlebihan. Pendidik perlu menganalisis serta menerapkan teknik pedagogis sebagai sarana untuk mengatasi miskonsepsi dan kesulitan siswa dalam memecahkan masalah numerik diantaranya memperbaiki prakonsepsi siswa, pembelajaran dengan model student centered learning, membuat peta konsep dan mind map, berlatih memecahkan soal dengan langkah-langkah algoritmik dan melakukan pembelajaran yang mencapai tingkat ketuntasan. Karena eberhasilan siswa dalam memahami materi stoikometri menjadi faktor penentu dalam mempelajari materi selanjutnya yang memerlukan konsep stoikiometri sebagai materi prasyarat.Kata kunci:Â Â stoikiometri, miskonsepi, kesulitan belajar, kompetensi pedagogik, pemecahan masalah
Android Based Educational Game in Learning and Teaching English Vocabulary
Authors: Insani Nurchintyawati, S.Pd.,M.Pd  
Published: March 2022

Vocabulary learning is often perceived as boring by learners, especially for those who grew up in the digital era. The use of online games in vocabulary learning and teaching can be one solution to solve this problem. Android is the current world-famous software nowadays. It is believed to help teachers in delivering knowledge effectively and efficiently. Therefore, this paper aims to illustrate the effectiveness of Android-based educational games to enhance the ability of learners in learning English vocabulary. The discussion includes overview about vocabulary, games, ICT tools in EFL classroom, and the use of educational games from Android (App Inventor) can improve students' English competence in learning vocabulary. Therefore, this paper will be explained about the use of Android-based educational games as one of the fun alternative teaching innovations to support creative teachers and students. And hopefully it can be useful and meaningful reference and information for the reader about the use of android based educational game in learning and teaching English Vocabulary.
Keywords: Android based educational game, vocabulary, ICT tool.
Narrative strategies in the poetics of fiction prose by Ya.V. Abramov
Authors: Монахов Александр Александрович 
Published: March 2022

Статья посвящена изучению нарративных стратегий и функций в художественном воплощении авторского сознания в произведениях выдающегося русского публициста, философа и прозаика Я.В. Абрамова. Ее целью является анализ подхода автора к объективированию субъекта, в результате которого достигается особое дискурсивное соотношение «автор - герой - читатель». Этой сложной повествовательной оптикой писателя обеспечивается корреляция субъектных уровней автора и первичного носителя речи (повествователя). Синтез нарративных технологий, событийность в произведениях как интеракция адресата и адресанта, следование принципу «герой как ценностный центр произведения» обеспечивают реализацию «эстетического намерения» автора (В. Шмид), в художественном мире произведений которого читатель формирует ценностный взгляд на природу и сущность человека, а также на себя самого.
The paper is devoted to the study of narrative strategies and functions in the artistic embodiment of the author's consciousness in the works of the outstanding Russian publicist, philosopher and prose writer Ya.V. Abramov. Its purpose is to analyze the author's approach to objectifying the subject, as a result of which a special discursive relationship “author - hero - reader” is achieved. This complex narrative optics of the writer provides a correlation between the subjective levels of the author and the primary carrier of speech (narrator). The synthesis of narrative technologies, eventfulness in works as an interaction between the addressee and the addressant, adherence to the principle of “the hero as the value In the artistic world of author’s works the reader forms a value view of the nature and essence of man and himself.
Lyrico-epic fundamentals in the poetry of Akhmed Khatkov
Authors: Хуажева Нурьят Хазретовна , Хатхе Асиет Асланбечевна 
Published: March 2022

Рассматриваются содержание, тематика и художественные черты поэтических произведений Ахмеда Хаткова, лирическое и эпическое начало в его творчестве, что тесно связано с постреволюционной эпохой в нашей стране. Выявляются истоки творчества, связь поэзии с фольклором адыгов, с традициями русской классической литературы. Выделяются этапы художественного творчества Хаткова (первый - 1920-е; второй - 1930-е годы) и их особенности. Поэтические произведения первого этапа - начало письменной поэзии адыгов, они посвящены природе, фактам из повседневности, небольшим картинкам действительности, поэт не стремится показать лирические переживания героев, широкое эпическое осмысление фактов жизни. Отмечается, что второй этап - это зрелый период творчества, расширяется тематика, появляются множество произведений с лирическим и эпическим составляющими, новые стилистические приемы, углубляются переживания и мысли лирического героя, стали складываться литературные жанры оды, лиро-эпической поэмы. Особое внимание уделено вопросам мастерства поэта в произведениях 1930-х годов, анализу выразительно-изобразительных средств, использованных в лирике.
The paper examines the content, themes and artistic features of the poetic works of Akhmed Khatkov, the lyrical and epic fundamentals in his work, which is related to the post-revolutionary era in our country. The origins of creativity, the connection of poetry with Adyghe folklore, with the traditions of Russian classical literature are revealed. The stages of Khatkov's artistic creativity are distinguished (the first - the 1920s; second - 1930s) and their features. The poetic works of the first stage are the beginning of the written poetry of the Adyghes, they are devoted to nature, facts from everyday life, small pictures of reality. The poet does not seek to show the lyrical experiences of the heroes, a wide epic understanding of the facts of life. It is noted that the second stage is a mature period of creativity, the subject is expanding, many works with lyrical and epic components appear, new stylistic techniques, the experiences and thoughts of the lyrical hero deepen, literary genres of the ode and lyrico-epic poem began to take shape. Particular attention is paid to the issues of the poet's skill in the works of the 1930s, the analysis of expressive and pictorial means used in lyrics.
A. Blok and D. Prigov: Angels and Demons
Authors: Шишхова Неля Магомедовна , Анкудинов Кирилл Николаевич 
Published: March 2022

В статье анализируется интеграция художественной практики А. Блока в постмодернистскую традицию, в частности, творчество Д. Пригова, где эта практика становится способом мотивировки поэтического знака. Обсуждается актуальная для истории русской литературы проблема: что стало с постмодерном как языком описания эпохи в XXI столетии, как он связан с предыдущей поэзией. Проблема демонологии и ее решения позволяют контекстуализировать модели выразительности и выделить основные парадигмы в стихотворениях двух названных поэтов. Отдельное внимание уделяется оппозиционной паре «ангелы и демоны», ее месту в пространстве стиха у А. Блока и новаторскому отношению к рассматриваемой проблеме Д. Пригова.
The article analyzes the integration of A. Blok's artistic practice into the postmodern tradition, in particular, the work of D. Prigov, where this practice becomes a way of motivating a poetic sign. The authors discuss a problem relevant to the history of Russian literature: what has become with postmodern as the language of description of the era in the 21st century, how it is associated with previous poetry. The specifics of demonology and its solutions make it possible to contextualize models of expressiveness and highlight the main paradigms in the poems of the two named poets. Special attention is paid to the opposition pair of "angels and demons", its place in the verse space of A. Blok and an innovative attitude to the problem under consideration of D. Prigov.
On the transformation of the emotional concept of Freude / Joy
Authors: Анищенко Алла Валерьевна , Хлопова Анна Игоревна 
Published: March 2022

Язык является знаковой системой, поэтому он может отражать чувства и эмоции человека. Объектом исследования является эмоциональный концепт Freude (радость) в немецкой лингвокультуре, а предметом - выявляемые в ходе лингвистического анализа изменения в содержании эмоционального концепта. Цель исследования состоит в установлении таких содержательных сдвигов. Предполагается, что эмоциональный концепт подвержен трансформации, вызванной социокультурными факторами, к которым можно отнести наряду с изменениями ценностных ориентаций и изменениями в системе коммуникаций. Эмоциональный концепт имеет полевую структуру и может быть реконструирован через анализ его составляющих.
Language is an iconic system, so it can reflect a person's feelings and emotions. The object of the study is the emotional concept Freude (joy) in German linguistic culture. The subject is changes in the content of the emotional concept identified during linguistic analysis. The aim of the study is to establish such meaningful shifts. The authors believe that the emotional concept is subject to transformation caused by sociocultural factors, which can be attributed along with changes in value orientations and changes in the communication system. The emotional concept as knowledge of the sociocultural deterministic emotional sphere has a complex multilevel field structure and can be reconstructed through the analysis of its constituents. Therefore, the semantic fields method and the free associative experiment method are used as the main research methods. As a result, the lexic-semantic field Freude (joy) is mapped to the associative field. The scientific significance of the work is the possibility of experimental establishment of the content of emotional concepts. The results obtained showed that the nucleus of the lexic-semantic field Freude (joy) and the associative field of the word partially coincide. However, the configuration of the field changes: nuclear constituents move to the periphery and vice versa. The transformation of the concept manifests itself in changing the connotation of the word Freude (joy). The practical value of the study lies in the possibility of applying the developed methodology in the practice of the university teaching of intercultural communication, linguoculturology etc.
Some observations on the lexicon of the legend "How the Nart Sausyryko got the fire for the Narts"
Authors: Долева Рузана Нальбиевна , Уракова Фатима Каплановна 
Published: March 2022

Предпринимается попытка исследования сказания «Как нарт Саусырыко добыл огонь нартам», являющегося в языковом аспекте образцом народной речи, вобравшем в себя все богатство и многообразие лексических, семантических, фразеологических и грамматических особенностей адыгских языков. Языковое своеобразие фольклора в целом, в том числе и нартского эпоса, не раз становилось центром различных лингвистических исследований. Тем не менее, фольклор до сих пор остается одним из богатейших источников изучения этнолингвистических особенностей адыгских языков и их диалектов, поскольку фольклорные тексты ставят перед исследователями множество вопросов. Каждый фольклорный текст - это микросистема, в которой зафиксированы вербальные формы разных поколений, они могут стать объектом изучения разных направлений лингвофольклористики. Сравнительный анализ лексикона сказания помог выделить лексические параллели, соответствия, встречающиеся в них.
An attempt is made to study the legend "How the Nart Sausyryko got the fire for the Narts", which in the linguistic aspect is an example of folk speech, which includes all the wealth and variety of lexical, semantic, phraseological and grammatical features of the Adyghe languages. The linguistic originality of folklore in general, including the Nart epic, has repeatedly become the center of various linguistic studies. Nevertheless, folklore remains one of the richest sources of study of the ethnolinguistic features of the Adyghe languages and their dialects, since folklore texts pose many questions to researchers. Each folklore text is a microsystem in which verbal forms of different generations are fixed, they can become the object of studying different directions of linguo-folkloristics. A comparative analysis of the legend lexicon helped to distinguish lexical parallels, correspondences found in them.
Linguistic and cultural peculiarities of interethnic dialogue in the text of an animated television series
Authors: Ломтева Татьяна Николаевна , Патрушева Екатерина Владимировна 
Published: March 2022

Рассматриваются языковые и культурологические черты межэтнического взаимодействия на примере американского анимационного сериала «Animaniacs». Языковая игра как актуализируемый лингвостилистический прием исследуется в контексте неотъемлемого компонента культуры различных народов, в том числе американской; определяется ее роль в межнациональной коммуникации; выявляются функции языковой игры, способствующие достижению авторской интенции и адекватному пониманию информационного посыла.
The paper focuses on considering linguistic and cultural aspects of interethnic dialogue functioning in the text of an animated television series from theoretical standpoint. The empiric data is based on the American animated comedy musical television series “Animaniacs”. We make an attempt at defining wordplay as an essential component of different cultures and advocate its role in structuring interethnic communication. The wordplay functional peculiarities are specified as contributing to the achievement of the author’s intention.
«Le grandi tardone si difendono»: divismo, sessualità e rappresentazione della maturità femminile
Authors: Busetta Laura 
Published: March 2022

This paper focuses on the relationship between cinematic stardom and aging, through the analysis of exemplary figures in in post-World War II Italy. Within a scenario in which sexualization pervades the entire media system, the decline of the star allows us to look at the female body as a mirror of transformations related to gender identities, new mass consumption, generational models, and social norms.
Against this backdrop, the contribution analyses the public discourse on aging which emerges on the pages of the magazine «Oggi», looking particularly at the representation of two emblematic figures: Greta Garbo and Marlene Dietrich.
Sophia Loren. La speranza di vita dell'ultima diva italiana
Authors: Pesce Sara 
Published: March 2022

With the release of La vita davanti a sé (Edoardo Ponti, 2020, Netflix) a number of interviews and documentaries have appeared on YouTube. Netflix-sponsored promotional materials and fan-circulated documentaries or interviews celebrate the Diva of the past and of the present, sustaining an ideal of resilience also supported by the flourishing silver economy of the last decades. The film, on the other hand, catches us by surprise, showing Loren’s elderly body in a graphic way and revealing the impossibility to hide its decadence. Focusing on the cultural continuities between today’s imaginary and that of the shapely diva of the ‘50s and ‘60s, this essay investigates Ponti-Loren’s attempt to find a new perspective on the Diva in light of her 86 years. A fundamental contradiction between an assenting old age and a retrograde approach comes to the fore.
PEMANFAATAN TEKNOLOGI INFORMASI KOMUNIKASI ( Studi Deskriptif Mengenai Pemanfaatan TIK pada Siswa Kelas VII SMP Negeri 1 Plumpang) Tahun Pelajaran 2018/2019
Authors: Ponco Bagyo Susilo, Juli Kristianto Sundarum, Muhamad Salim, Septi Parmasari, 
Published: March 2022

Penelitian ini bertujuan mendeskripsikan tentang pemanfaatan media IT/TIK (Teknologi Informasi dan Komunikasi) pada Siswa kelas 7 SMP Negeri 1 Plumpang taun pelajaran 2018-2019. Melalui penelitian ini diharapkan siswa mendapatkan wacana baru untuk dapat memanfaatkan kemajuan perangkat teknologi informasi dan komunikasi yang membantu apa yang mereka lakukan, Peneliti ingin tahu persis bagaimana gambaran pemanfaatan teknologi informasi dan komunikasi di SMP Negeri 1 Plumpang. Berbeda dengan beberapa penelitian sebelumnya Dilakukan di fasilitas atau fasilitas teknologi informasi di Indonesia masih terbatas dan tidak merata. Metode penelitian ini yaitu deskriptif, dengan pengumpulan data melalui instrumen tes dan non tes, lembar observasi, catatan lapangan dan dokumentasi. Dalam penelitian ini, peneliti tertarik untuk mengidentifikasi bagaimana gambaran siswa SMP Negeri 1 Plumpang mengenali dan memanfaatkan teknologi informasi di sekolah dari usia siswa tersebut saat pertama menggunakan fasilitas IT. Kapan siswa kelas 7 SMP Negeri 1 Plumpang tahun pelajaran 2018-2019 mengenali dan memanfaatkan fasilitas teknologi informasi seperti komputer, laptop, Smartphone dan Internet. Fasilitas teknologi informasi seperti komputer, laptop dan internet yang dimiliki oleh sekolah, dan alasan-alasan yang mendorong siswa SMP Negeri 1 Plumpang memanfaatkan teknologi informasi di sekolah hingga seberapa sering penggunaan alat teknologi informasi yang mereka lakukan dengan memanfaatkan sarana teknologi seperti komputer, laptop, dan internet di sekolah.