bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Problematika Pembelajaran Daring Mahasiswa pada Masa Pandemi Covid-19
Authors: Aqmarima Alivia Izazi , Fatah Habib Muhammad , Latifah Rusydan , Putranto Sumbaji 
Published: April 2022

Sejak terdeteksinya virus corona di Indonesia memberikan dampak terhadap berbagai sektor bidang terutama pendidikan. Kementerian pendidikan dan kebudayaan Indonesia telah menetapkan Surat Edaran Menteri Nomor 4 Tahun 2020 tentang Pelaksanaan Kebijakan Pendidikan dalam Masa Darurat Penyebaran Corona Virus Disease 2019 (COVID-19) dan Surat Edaran Sekretaris Jenderal Nomor 15 Tahun 2020 tentang Pedoman Penyelenggaraan Belajar dari Rumah dalam Masa Darurat Penyebaran Corona Virus Disease 2019 (COVID-19). Pandemi membuat pelaku pendidikan menjadi lebih dekat dengan aplikasi pembelajaran. Tentunya hal tersebut merupakan tantangan bagi pelaku pendidikan dalam pembelajaran daring. Berdasarkan hal tersebut peneliti mempunyai tujuan untuk menganalisis problematika pembelajaran daring mahasiswa pada masa pandemi. Metode penelitian yang digunakan yaitu penelitian kualitatif dengan metode deskreptif. Hasil dan pembahasan penelitian ini diperoleh dengan angket kuisioner. Hasil penelitian ini menunjukkan bahwa pengaruh pembelajaran daring yaitu: sarana prasarana yang kurang mendukung, ketidakmampuan mahasiswa untuk belajar secara mandiri, rendahnya motivasi belajar mahasiswa.
Analisis Model Pembelajaran Novick terhadap Pemahaman Konsep Peserta Didik
Authors: Putri Nadia Eka , Anwar Syaiful , Nasution Sri Purwanti 
Published: April 2022

Abstrak. Konsep Matematika saling berhubungan. Namun belakangan ini muncul fakta bahwa kemampuan pemahaman konsep masih rendah. Sehingga diperlukan penerapan strategi pembelajaran baru untuk melatihnya, yaitu model pembelajaran Novick. Tujuan penelitian ini adalah untuk menyelidiki apakah kemampuan pemahaman konsep siswa pada materi kubus dan balok yang menggunakan model pembelajaran Novick lebih tinggi daripada siswa yang menggunakan pembelajaran konvensional. Metode yang digunakan adalah kuantitatif dengan jenis quasi eksperimen, desainnya nonequivalent posttest-only control group design. Populasi penelitian adalah siswa kelas VIII SMP Bhakti Pemuda, Tanjung Bintang , dengan sampel siswa kelas VIIIA (32 siswa) dan kelas VIIIB (31 siswa). Instrumen berupa tes uraian, tentang kemampuan pemahaman konsep sebanyak 8 butir pertanyaan. Hasil penelitian memperlihatkan rata-rata nilai kemampuan pemahaman konsep siswa kelas eksperimen sebesar 54,97 dan siswa kelas kontrol sebesar 45,27. Hasil dari uji Anakova data posttest diperoleh . Artinya, kemampuan pemahaman konsep siswa yang menggunakan model pembelajaran Novick lebih tinggi daripada siswa yang menggunakan pembelajaran konvensional.

Kata Kunci: Pemahaman Konsep, Model Pembelajaran, Novick
Abstract. Mathematical Concepts are interconnected. However, recently the fact emerged that the ability to understand concepts is still low. So it is necessary to apply a new learning strategy to train it, namely the Novick learning model. The purpose of this study was to investigate whether students' conceptual understanding skills on cube and block material using the Novick learning model were higher than students using conventional learning. The method used is quantitative with a quasi-experimental type, the design is nonequivalent posttest-only control group design. The population of the study was class VIII SMP Bhakti Pemuda, Tanjung Bintang, with samples of class VIIIA (32 students) and class VIIIB (31 students). The instrument is in the form of a description test, about the ability to understand concepts as many as 8 questions. The results showed that the average value of the concept understanding ability of the experimental class students was 54.97 and the control class students were 45.27. The results of the Ananova test for posttest data obtained . That is, the ability to understand concepts of students who use the Novick learning model is higher than students who use conventional learning.
Keywords: Concept Understanding, Learning Model, Novick
Strategi Peningkatan Produktivitas Padi melalui Sistem Salibu
Authors: Marpaung David Septian Sumanto 
Published: April 2022

<p>Beras merupakan makanan utama bagi masyarakat Indonesia. Kebutuhan akan beras, melalui tanaman padi meningkat seiring dengan peningkatan jumlah penduduk di Indonesia. Namun, ketersediaan lahan untuk bercocok tanam, terus berkurang dari tahun ke tahun. Sistem salibu merupakan salah satu metode yang dapat diterapkan untuk peningkatan produktivitas padi yang efektif dan ramah lingkungan. Berbagai macam strategi untuk mendukung sistem salibu dalam peningkatan nilai produksi tanaman padi telah diterapkan, diantaranya perlakuan waktu pemotongan tunggul, perlakuan tinggi pemotongan tunggul, manajemen air, penggunaan pupuk, dan penggunaan varietas unggul. Melalui tulisan ini diharapkan dapat memberikan informasi tentang sistem salibu padi dan strategi peningkatan produktivitasnya.</p>
Dynamically Evaluating the Performance of Naturally Occurring Additives to Control Lost Circulation: On the Effect of Lost Circulation Material Type, Particle-Size Distribution, and Fracture Width
Authors: Ashoori Siavash , Bahari Moghadam Mahdi , Nazemi Rasoul , Nooripoor Vahid , Ahmadabadi Mahmud 
Published: April 2022

Summary
Lost circulation is one of the most challenging problems during drilling of oil and gas wells. This issue leads to significant loss of drilling fluid, increase of nonproductive time as well as dictating additional costs to drilling companies. Lost circulation may also lead to other consequences, including stuck pipe, poor hole cleaning, and well control issues. How to efficiently control lost circulation have been traditionally depending on the type of the used lost circulation material (LCM). Injection of commonly available materials (without any further process on their chemical properties) into the thief zone is a common method of lost circulation control. These nonmodified materials are named as conventional LCMs against the unconventional LCMs which are designed/produced just for fluid lost control.
The objective of this paper is to comparatively investigate the performance of cane, oak shell, wheat, and mica as LCM of water-based drilling fluid exposed to fractured formations. These materials were chosen because of their low cost, easy access, and compatibility with the environment. The sealing efficiency of these materials was assessed at different particle-size distributions (PSDs) for proper treatment of loss circulation. To do so, an experimental setup containing a cell with adjustable fracture size was designed.
Among the LCM formulations made of each of the materials, oak shell formulations are better than the others, followed by mica and cane blends, respectively. The results reveal that combining the materials together is a better treatment than the separate use of them. As it will be seen in detail later, high diversity in particle size (broad PSD) causes more efficient control of fluid loss. Also, to reduce the dependency of sealing ability of LCM formulation on fracture size, mixing of the materials with different particle sizes and shapes is recommended.
Stability improvement of laccase for micropollutant removal of pharmaceutical origins from municipal wastewater
Authors: Meiczinger Mónika , Varga Béla , Wolmarans Lana , Hajba László , Somogyi Viola 
Published: April 2022

Abstract
Micropollutants are persistent and hazardous materials in low concentrations (ng·L− 1 – µg·L− 1), including substances such as pharmaceuticals, personal care products and industrial chemicals. The advancement of analytical chemistry has allowed for the detection of micropollutants; however, an efficient and economical treatment solution is yet to be installed. Fungal laccase has been a successful biocatalyst of these compounds. However, large-scale application of free enzyme is currently not feasible for removing water-borne micropollutants, partly due to relatively rapid loss in enzyme stability. In this paper, three types of cyclodextrin, α, β and γCD, were chosen to immobilise the laccase under various conditions with the aim to improve the stability of the enzyme. Laccase activity was chosen as a response parameter, and laccase-cyclodextrin binding was evaluated by Fourier-transform infrared spectroscopy (FTIR). Results showed an optimum using α-cyclodextrin immobilisation. At that level, α-cyclodextrin increased the half-life of laccase and slightly improved its activity in all tested pH by physically bonding to laccase. By protecting the enzyme structure, activity was maintained under a range of circumstances (acidic conditions, from 10°C to 50°C). Under room temperature and at pH 5, α-cyclodextrin-laccase nanocomposite had a better removal efficiency of diclofenac compared to free laccase of the same concentration.
Comparative genomics reveals plasmid-encoded genes associated with Klebsiella infection in colonized patients
Authors: Vornhagen Jay , Roberts Emily , Unverdorben Lavinia , Mason Sophia , Patel Alieysa , Crawford Ryan , Holmes Caitlyn , Sun Yuang , Teodorescu Alexandra , Snitkin Evan , Zhao Lili , Simner Patricia , Tamma Pranita , Rao Krsihna , Kaye Keith , Bachman Michael 
Published: April 2022

Abstract
Klebsiella frequently colonizes the gut and colonization is associated with subsequent infection. To identify genes associated with progression from colonization to infection, we undertook a case-control comparative genomics study. Concordant cases (N = 85), where colonizing and invasive Klebsiella isolates were identical strain types, were matched to asymptomatically colonizing controls (N = 160). Thirty-seven genes were significantly associated with infection, 27 of which remained significant following adjustment for patient variables and bacterial phylogeny. Infection-associated genes were not previously characterized virulence factors, but instead a diverse group of stress resistance, regulatory and antibiotic resistance genes, despite careful adjustment for antibiotic exposure. Many infection-associated genes were plasmid borne, and for some, the relationship with infection was mediated by gut dominance. Five infection-associated genes were validated in a geographically independent cohort of colonized patients. This study identifies novel genes that are reproducibly associated with progression to infection in patients colonized by diverse Klebsiella.
Uptake of Screening and Risk Reducing Recommendations Among Women with Hereditary Breast and Ovarian Cancer Syndrome Evaluated at a Large Urban Comprehensive Cancer Center
Authors: Assad Hadeel , Levitin Maria , Petrucelli Nancie , Manning Mark , Thompson Hayley S , Chen Wei , Jang Hyejeong , Simon Michael S 
Published: April 2022

Abstract
Purpose: Carriers of pathogenic variants in BRCA1/2 have an elevated lifetime cancer risk warranting high-risk screening and risk-reducing procedures for early detection and prevention. We report on prevention practices among women with pathogenic BRCA variants to evaluate compliance with NCCN recommendations and to identify barriers to guideline-recommended care.Methods: We evaluated women tested positive for pathogenic variant in BRCA1/2 via 54-item questionnaire to measure socio-demographics, medical history, rates of cancer screening and risk-reducing surgery, disclosure of test results, and cancer worry. We reported rates of compliance with risk-reducing salpingo-oophorectomy (RRSO), risk-reducing mastectomy (RRM) and NCCN guidelines (version 3.2019). A multivariable logistic regression analyses was used to identify predictors of these outcomes. Results: Of 129 evaluable women with pathogenic BRCA1/2 variants, 95 (74%) and 77 (60%) underwent RRSO and RRM, respectively, and 107 (83%) were considered adherent to NCCN guidelines. After multivariable analyses, personal history of breast or ovarian cancer was positively associated with RRM (OR = 2.81; 95% CI 1.10 – 7.44; p = 0.025). Increasing age was associated with an increased likelihood of RRSO (OR=1.05; 95% CI 1.01 – 1.09; p = 0.022) and a decreased likelihood for RRM (OR=0.96; 95%CI 0.92 – 0.99; p value = 0.013). Women who had RRM were 3 times more likely to undergo RRSO (OR = 3.28; p = 0.004). Rates of RRSO or RRM were not impacted by participant race, education, annual household income, marital status, or family history. There was near universal (127/129) disclosure of genetic test results to family members resulting in the discovery of 1 relative with a pathogenic variant (range = 0-8) through cascade testing. Conclusion: Long term follow up of a cohort of women with pathogenic variants in BRCA1/2 revealed high rates of compliance with screening and risk reducing recommendations. Further efforts should focus on increasing compliance among unaffected carriers especially for RRSO.
Genomic landscape, immune characteristics and a prognostic mutation signature of cervical cancer in China
Authors: Liu Jing , Li Zirong , Lu Ting , Pan Junping , Li Li , Song Yanwen , Hu Dan , Zhuo Yanhong , Chen Ying , Xu Qin 
Published: April 2022

Abstract
Purpose: This study aimed to analyze genomic alteration profiles and immune characteristics of a cohort of Chinese cervical cancer patients to understand why certain patients benefited from molecular targeted therapies, immunotherapy and their prognostic significance.Methods: PD-L1 expression, and clinicopathological information from 98 cervical cancer samples. Differences in PD-L1 expression and gene mutations between squamous cell carcinoma (SCC) and adenocarcinoma (AC) were analyzed by chi-square test or Fisher's exact test. Differences in gene mutations between our cohort and the Cancer Genome Atlas (TCGA) cohort were tested by Fisher's exact test. Logistic regression was used to analyze factors influencing TMB-high.Results: Positive PD-L1 expression was significantly higher in cervical SCC than in cervical AC (87% vs. 39%, p < 0.001). Frequently mutated genes in cervical cancer included PIK3CA, KMT2D, and KMT2C genes, among others. PIK3CA gene mutation rates were significantly higher in SCC than in AC (p = 0.004). TERT gene mutation rate was significantly higher in our cohort than TCGA cohort (12% vs. 1%, p < 0.001). The independent predictors of TMB-high were KMT2C and LRP1B gene mutations (p < 0.05). we also found the PTEN mutations were associated with worse survival (median PFS, 12.16 vs. 21.75 months, p = 0.0024)Conclusion: Cervical SCC and AC have different molecular profiling and immune characteristics, suggesting that targeted treatments for SCC and AC patients may improve clinical outcomes. KMT2C and LRP1B gene mutations are independent predictors of TMB-high status in cervical cancer. We have also proposed the prognostic value of PTEN mutations.
A Universal Graph Deep Learning Interatomic Potential for the Periodic Table
Authors: Chen Chi , Ong Shyue 
Published: April 2022

Abstract
Interatomic potentials (IAPs), which describe the potential energy surface of a collection of atoms, are a fundamental input for atomistic simulations. However, existing IAPs are either fitted to narrow chemistries or too inaccurate for general applications. Here, we report a universal IAP for materials based on graph neural networks with three-body interactions (M3GNet). The M3GNet IAP was trained on the massive database of structural relaxations performed by the Materials Project over the past 10 years and has broad applications in structural relaxation, dynamic simulations and property prediction of materials across diverse chemical spaces. About 1.8 million potentially stable materials were identified from a screening of 31 million hypothetical crystal structures, demonstrating a machine learning-accelerated pathway to the discovery of synthesizable materials with exceptional properties.
Effects of building envelope features on airflow and pollutant dispersion within a symmetric street canyon
Authors: Sin Chung Hyok , Cui Peng-Yi , Jon Kwang Song , Luo Yang , Huang Yuandong 
Published: April 2022

Abstract

Building envelope features (BEFs) have attracted more and more attention as they have a significant impact on flow structure and pollutant dispersion within street canyons. This paper conducted CFD numerical models validated by wind-tunnel experiments, to explore the effects of the BEFs on characteristics of the airflow and pollutant distribution inside a symmetric street canyon under perpendicular incoming flow. Three different BEFs (balconies, overhangs, and wing walls) and their locations and continuity/discontinuity structures were considered. For each canyon with various BEFs, the air exchange rate (ACH), airflow patterns, and pollutant distributions, including the mean and maximum K values were evaluated and compared in detail. The results show that compared to the regular canyon, the BEFs will reduce the ACH of the canyon, but increase the disturbances (the proportion of ACH′) inside the canyon. The BEFs on the leeward wall have the least influence on the in-canyon airflow and pollutant distributions, followed by that on the windward wall. Then when the BEFs are on both walls, the ventilation capacity of the canyon is weakened greatly, and the pollutant concentration in the ground center is increased significantly, especially near the windward side. Moreover, the discontinuity BEFs will weaken the effect of the continuity BEFs on the in-canyon flow and dispersion, specifically, the discontinuity BEFs lead to the more dispersed distribution of high pollutant concentrations. These findings can help optimize the BEFs design to enhance ventilation and mitigate traffic pollution.
Pelvic floor disorders and sexual function in cervical cancer survivors: a meta-analysis
Authors: Shan Xiao , Qian Maolin , Wang Lan , Liu Xiaoqin 
Published: April 2022

Abstract
Purpose Pelvic floor disease (PFD) and female sexual dysfunction (FSD) are symptoms affecting the quality of life of patients with cervical cancer after treatment. Our purpose is to describe the prevalence of PFD and FSD in women with cervical cancer (CC).Methods We searched PubMed, Embase, and the Cochrane Library from database inception to 31 Jan 2021 and Selected articles assessing UI, FI, and FSD in women with CC. Observational studies were included if the literature studied UI and FI, and FSD.Results Of the 1037 studies, 14 were included: 7 studied FSD, 9 evaluated UI, and 3 described FI. Due to the use of different populations and treatment methods, the results were highly heterogeneous. After treatment, the prevalence of FSD, UI, and FI in CC patients was 45.0% (95% confidence interval (CI) 21.8%, 68.3%), 34.1% (95% confidence interval (CI) 25.5%, 42.7%%) , and 11.1% (95% confidence interval (CI) 4.8%, 17.3%%), respectively. The results showed that different countries are the sources of high heterogeneity of UI and FI (P＜0.001).Conclusions In this meta-analysis, the prevalence of PFD and FSD was quite high. These results are important for increasing attention to pelvic floor disease and early prevention and rehabilitation.
Pinolenic acid exhibits Anti-inflammatory and Anti-atherogenic effects in Peripheral blood-derived Monocytes from patients with Rheumatoid Arthritis
Authors: Takala Rabaa , Ramji Dipak , Andrews Robert , Zhou You , Farhat Mustafa , Elmajee Mohammed , Rundle Shelley , Choy Ernest 
Published: April 2022

Abstract
Objectives: Pinolenic acid (PNLA), an omega-6 polyunsaturated fatty acid from pine nuts, has anti-inflammatory and anti-atherogenic effects. We aimed to investigate the direct anti-inflammatory effect and anti-atherogenic effects of PNLA on activated purified CD14 monocytes from peripheral blood of patients with rheumatoid arthritis (RA) in vitro.Methods: Flow cytometry was used to assess the proportions of CD14 monocytes expressing TNF-α, IL-6, IL-1β, and IL-8 in purified monocytes from patients with RA after lipopolysaccharide (LPS) stimulation with/without PNLA pre-treatment. The whole genomic transcriptome (WGT) profile of PNLA-treated, and LPS-activated monocytes from patients with active RA was investigated by RNA-sequencing.Results: PNLA reduced percentage of monocytes expressing cytokines: TNF-a by 23% (p=0.048), IL-6 by 25% (p=0.011), IL-1B by 23% (p=0.050), IL-8 by 20% (p=0.066). Pathway analysis identified upstream activation of peroxisomes proliferator-activated receptors (PPARs), sirtuin3, and let7miRNA, KLF15 which are anti-inflammatory and antioxidative. In contrast, DAP3, LIF and STAT3, which are involved in TNF-a, and IL-6 signal transduction, were inhibited. Canonical Pathway analysis showed that PNLA inhibited oxidative phosphorylation (p=9.14E-09) and mitochondrial dysfunction (p=4.18E-08), while the sirtuin (SIRTs) signalling pathway was activated (p=8.89E-06) which interfere with the pathophysiologic process of atherosclerosis. Many miRNAs were modulated by PNLA suggesting potential post-transcriptional regulation of metabolic and immune response that has not been described previously. Multiple miRNAs target pyruvate dehydrogenase kinase-4 (PDK4), single-immunoglobulin interleukin-1 receptor molecule (SIGIRR), mitochondrially encoded ATP synthase membrane subunit 6 (MT-ATP6) and Acetyl-CoA Acyltranferase2 (ACAA2); genes implicated in regulation of lipid and cell metabolism, inflammation, and mitochondrial dysfunction.Conclusion: PNLA has potential anti-atherogenic and immune-metabolic effects on monocytes that are pathogenic in RA and atherosclerosis. Dietary PNLA supplementation regulates key miRNAs that are involved in metabolic, mitochondrial, and inflammatory pathways.
Therapeutic plasma exchange in multiple sclerosis patients with an aggressive relapse–an observational analysis in a high–volume center
Authors: Bunganic R. , Blahutova S. , Revendova K. , Zapletalova O. , Hradilek P. , Hrdlickova R. , Ganesh A. , Cermakova Z. , Bar M. , Volny Ondrej 
Published: April 2022

Abstract
Introduction: An evidence–based treatment for a Multiple Sclerosis (MS) relapse is an intravenous administration of 3–5g of Methylprednisolone. In case of insufficient effect or corticosteroids intolerance, the therapeutic plasma exchange (TPE) is indicated.Objective: To assess the clinical effect of TPE in treatment of relapse in patients with relapsing–remitting MS (RRMS).Methods: We enrolled 155 patients meeting the following criteria: (1) age >18, (2) RRMS according to the McDonald´s 2017 criteria, (3) MS relapse and insufficient effect of corticosteroids/corticosteroids intolerance, (4) baseline EDSS <8. Exclusion criteria: (1) progressive form of disease, (2) history of previous TPE. Following parameters were monitored: EDSS changes (before and after corticosteroid treatment, before and after TPE; EDSS after TPE was assessed at the next clinical follow–up at the MS Center), and improvement of EDSS according to the number of procedures and baseline severity of relapse.Results: 115 females (74%) and 40 males (26%) were included. The median age was 41 years (IQR 33–47)–131 patients underwent the pulse corticosteroids treatment and TPE, while 24 patients underwent only TPE without any previous corticosteroid treatment. Median baseline EDSS was 4.5 (IQR 3.5–5.5), median EDSS after finishing steroids was 4.5 (IQR 4.0–5.5). EDSS prior to the TPE was 4.5 (IQR 4–6), EDSS after TPE was 4.5 (IQR 3.5–5.5). We observed a significant improvement in the EDSS after TPE (p<0.001). Sex differences were seen in TPE effectiveness, with average improvement of EDSS in females being –0.43 (SD±0.69) and in males being –0.069 (SD±1.05), p=0.048. There was no difference in EDSS improvement by age category: 18–30 years, 31–40 years, 41–50 years, >50 (p=0.94), nor by total TPE count (p=0.91). Conclusion: In this retrospective study of patients with an aggressive relapse and insufficient effect of intravenous corticosteroid treatment, a significant effect of TPE on EDSS improvement was observed. There was no significant difference in TPE effectivity according to the number of procedures, age, nor severity of a relapse. In this cohort, TPE was more effective in females.