bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute systemic complications of intravitreal bevacizumab and triamcinolone injections – a comparative study
Authors: Johari Mohammad Karim , Askari Malihe , Amini Abdulrahim , Yasemi Masoud 
Published: May 2022

Introduction: Macular edema is a common visual threatening complication in patients with diabetic retinopathy and retinal vein occlusion. The injection of intravitreal drugs, such as anti-vascular endothelial growth factor (anti-VEGF) and corticosteroids, revolutionized the treatment of these diseases.
Aim: To compare and assess the acute systemic complications of intravitreal bevacizumab and triamcinolone injections in patients with diabetic retinopathy and retinal vein occlusion.
Materials and methods: The study population included 211 patients with diabetic retinopathy and retinal vein occlusion who required intravitreal injections of bevacizumab and triamcinolone. In this study, 118 patients had generally received intravitreal injections with bevacizumab and the rest (93 patients) injections with triamcinolone. Experimental data, including demographic information, number of injections, the history of comorbidities, intraocular pressure, and systemic hypertension before and after injections, were recorded on specific forms following groups’ classification. In addition, the incidence of various complications was investigated during one month after the intravitreal injections.
Results: In the present study, we included 211 patients (mean age 62.41±11.34 years, median - 63 years). The results showed that there was no significant correlation between the injectable drug and changes in increased intraocular pressure (IOP) (p=0.66). No significant difference was detected for systemic hypertension in any of the studied groups. On the other hand, the incidence of complications of blood sugar, facial skin redness, neurological problems of TIA and CVA, myocardial infarction, vascular problems after injection, and ocular complications were estimated to be zero, 1.4, 0, 0.8, 0, and 6.1%, respectively.
Conclusions: Overall, the results indicated a prevalence of 1.4% for systemic complications and a prevalence of 6.1% for ocular complications. Accordingly, it seems that intravitreal injections of both drugs studied in the present study are placed in the group of low complication medications.
Quality of life in diabetic foot ulcer, grade 3: associated demographic factors
Authors: Polikandrioti Maria 
Published: May 2022

Abstract

Introduction: Patients with diabetic foot ulcer grade 3 experience some limitations that adversely affect their quality of life (QoL).
Aim: The aim of the study was to explore demographic characteristics associated with the quality of life of diabetic foot ulcer patients, grade 3.
Materials and methods: The present study recruited 120 diabetic foot ulcer patients. Data collected by completion of SF-36 Health Survey (SF-36).
Results: Of the 120 participants, 65.8% were men and 73% were more than 60 years of age. Patients showed moderate to high levels of quality of life in social functionality, energy/fatigue, emotional well-being, and physical pain (medians: 50, 60, 72, and 67.5, respectively) and poor levels in physical functioning, role physical, and role emotional (medians: 22, 0 and 0, respectively). In addition, patients had moderate levels of quality of life in general health (median: 48.5). ﻿It was observed that physical functioning was significantly associated with place of residence (p=0.005). Moreover, physical role was significantly associated with age (p=0.020) and occupation (p=0.018), while emotional role was significantly associated with age (p=0.012), marital status (p=0.016), and occupation (p=0.012). Energy/fatigue was significantly associated with age (p=0.026), marital status (p=0.018), and occupation (p=0.009). Emotional well-being was significantly associated with gender (p=0.009), level of education (p=0.001), and occupation (p=0.007). Social functionality was significantly associated with marital status (p=0.001) while pain was significantly associated with education level (p=0.010). General health was significantly associated with marital status (p=0.037), and place of residence (p=0.024).
Conclusions: The findings of the present study may adequately inform stakeholders in the field of diabetic foot ulcer grade 3 when planning effective care.
Le porno prend la place laissée vacante par les adultes dans l’éducation à la sexualité
Authors: Rohmer Thomas , Gilloots Marie , Stavroulakis Sophie 
Published: May 2022

Résumé Comment lutter contre l’exposition des mineurs à la pornographie ? Au cours de cette interview, Thomas Rohmer expose les actions de l’Observatoire de la parentalité et de l’éducation numérique ( open) sur le plan juridique pour imposer des contraintes au secteur de la pornographie en ligne. Il présente également la réflexion et les outils à destination des adultes pour leur permettre de ne pas esquiver les questions des adolescents concernant la sexualité, et les actions que mène l’association avec les acteurs de terrain, parents ou professionnels. Il interroge enfin la mise en œuvre de l’éducation à la sexualité à l’Éducation nationale.
La mort à distance interrogée
Authors: Desjars de Keranrouë Romain , Rival Xavier 
Published: May 2022

Aujourd’hui, en l’absence de toute aviation adverse, évoluant à une altitude suffisante pour ne pas être inquiétés par les défenses anti-aériennes ennemies, les pilotes et les navigateurs de combat ne redoutent que l’accident qui les conduirait à s’éjecter en territoire hostile. Les équipages de drones armés, bien qu’ils soient déployés sur les théâtres d’opérations où ils opèrent, courent encore moins de risques. Et les développements technologiques laissent d’ailleurs entrevoir de nouvelles façons de combattre à distance dans le milieu spatial ou le cyberespace. Faire la guerre serait-il alors pour eux de l’ordre du virtuel ?
Les séparatismes pro-russes en Moldavie
Authors: Lambert Michael Éric 
Published: May 2022

La Moldavie, petit pays latin d’Europe orientale, est apparue depuis le 24 février sur les cartes. À la frontière entre Roumanie et Ukraine, Chişinău, la capitale, doit compter avec deux territoires, l’un sécessionniste – la Transnistrie – et l’autre autonomiste – la Gagaouzie – qui pourraient faire basculer le destin des Moldaves.
Weak idempotent rings
Authors: Wasihun Dereje , Abebaw Tilahun , Yitayew Yibeltal , Kolluru Venkateswarlu 
Published: May 2022

In this paper is to introduce the notion of weak idempotent rings as a generalization of Boolean like rings. We obtain many formal properties of the class of weak idempotent rings and furnish certain examples of the class of weak idempotent rings. Furthermore, we obtain the properties of completely prime ideal and left and right completely primary ideals of weak idempotent rings.
Sebuah ANALISIS KEPUASAN MASYAKARAT TERHADAP ALOKASI BBM BERSUBSIDI DI KEC.JOHAN PAHLAWAN ACEH BARAT
Authors: Febriyanti Melani 
Published: May 2022

Abstrak: Penelitian ini bertujuan untuk menganalisis bahan bakar yang disubsidikan oleh pemerintah yaitu minyak solar dan premium, Bbm bersubsidi sangat dibutuhkan oleh masyarakat di wilayah Kec.Johan Pahlawan terutama bagi nelayan serta rakyat yang memiliki penghasilan rendah. Bahan bakar minyak premium terutama yang sangat diincar atau dicari masyarakat, hal tersebut dikarenakan harga yang cukup jauh lebih murah antara bbm bersubsidi lainnya. Kuesioner tersebar ke Seluruh Kec.Johan Pahlawan, Aceh Barat. Pengambilan sampel dilakukan dengan mempertimbangkan keterwakilan responden dari setiap Kec.Johan Pahlawan, sebanyak 47 responden secara media online. Data ini dianalisis dengan menggunakan jenis metode pendekatan kuantitatif, dengan teknik mengumpulkan data sesuai dengan yang sebenarnya kemudian data tersebut diolah, disusun dan dianalisis dengan metode Statistika Deskritif. Untuk Pengukuran Variabel diukur dengan service quality menggunakan Demensi Bukti Langsung (Tangibles), Kehandalan (Realiability), Daya Tanggap (Responsiveness), Jaminan (assurance) & Empati (Empathy). (parasuraman et al, 1988). Tingkat kepuasan masyarakat Kec.Johan Pahlawan dikelompokkan dalam tiga kategori Rendah, Sedang dan Tinggi.
Microprojectile andAgrobacterium-Mediated Transformation of Pioneer Elm
Authors: Bolyard Mark G. , Hajela Ravindra K. , Sticklen Mariam B. 
Published: May 2022

AbstractWe have transformed internode sections of the hybrid elm cultivar “Pioneer” to assess the possibilities of introducing significant genes into elms. Foreign DNA encoding beta-glucuronidase (GUS) was introduced into internode sections using microprojectile- orAgrobacterium tumefaciens-mediated transformation. Positive signals were detected by Southern analysis. Also, some enzymatic activity was detected inAgrobacteriumtransformed cultures using a fluorogenic assay.
Tiempo al PSA nadir como un factor de respuesta en pacientes con CPRC metastásico tratados con abiraterona
Authors: Sánchez-Martínez Néstor , Bautista-Vidal Carlos , Morales-Jiménez Pedro , García Galisteo Emilio 
Published: May 2022

Objetivo: Objetivar si el tiempo a conseguir un PSA nadir se relaciona con retraso en la progresión de la enfermedad.

Material y métodos: Estudio retrospectivo de 36 pacientes tratados con acetato de abiraterona en nuestro centro entre enero de 2014 y mayo de 2018 en fase de resistencia a la castración (CPRC) M1. Evaluamos los niveles de PSA al inicio del tratamiento, después de 4, 8 y 12 semanas, así como en los periodos sucesivos según nuestro protocolo. La respuesta de PSA se define como una disminución de ≥30% desde el inicio del tratamiento y la progresión de PSA como un aumento de ≥25% desde el inicio. Se considera progresión que suponga retirada de tratamiento aquella que asocie al menos dos de los siguientes criterios: progresión de PSA, progresión clínica y progresión radiológica. Hemos realizado un análisis de regresión lineal para las variables PSA al diagnóstico, PSA nadir, tiempo al nadir, PSA doubling time y descenso de al menos un 30% del nadir.

Resultados: En nuestra serie, el tiempo al nadir en la regresión lineal se asocia de manera positiva con la progresión, obteniendo mejores supervivencias libres de progresión cuando se consigue un PSA nadir a más largo plazo (p<0.018); de manera que por cada mes de retraso en alcanzar el nadir se espera una progresión 0.8 meses más tardía.

Conclusiones: En nuestra serie alcanzar un PSA nadir más tardíamente se relaciona con una mejora en la supervivencia libre de progresión
Manejo de la lesión rectal durante la prostatectomía radical: Nuestra experiencia y revisión de la literatura
Authors: Sánchez-Llopis Anna , Blanco-Silvestre Marc , Abad-Carratalá Guillem , Martínez-Meneu Pedro , Monsonís-Usó Rosa , Barrios-Arnau Laura , Ponce-Blasco Paula , Garau-Perelló Carmen , Di Capua-Sacoto Carlos , Rodrigo-Aliaga Miguel 
Published: May 2022

Objetivo: Evaluar la incidencia, los posibles factores de riesgo y el manejo de la lesión rectal durante la prostatectomía radical.
Diseño, metodología o aproximación: La lesión rectal es una complicación poco frecuente pero potencialmente grave de la prostatectomía radical (PR). La evidencia actual es limitada debido a que la mayoría de los estudios se basan en series relativamente pequeñas.
Se revisaron de manera retrospectiva un total de 147 prostatectomías radicales laparoscópicas de enero de 2017 a abril de 2021. Se encontraron 4 pacientes con lesión rectal durante el procedimiento.

Resultados: Del total de pacientes con lesión rectal durante el procedimiento existía extensión extraprostática en la RM precirugía en el 50% de los pacientes. Ninguno tenía antecedentes de RT previa. Se realizó cierre primario mediante dos capas de sutura en todos los casos. En un caso (25%) se realizó colostomía intraoperatoria. Uno de los cuatro pacientes (25%) desarrolló una fístula rectal con peritonitis secundaria por la que tuvo que ser reintervenido. El tiempo en dieta absoluta varió desde 0 días a 2 días y el tiempo de antibioterapia difirió en todos los pacientes.

Discusión: La lesión rectal ocurre en el 0.1-1.8% de pacientes sometidos a prostatectomía radical e incrementa de manera significativa la morbilidad del procedimiento. La mayoría de las lesiones rectales se producen durante las maniobras de disección del plano entre las vesículas seminales, la próstata y el recto. Para su detección se recomienda realizar un tacto rectal y insuflar aire por el recto intraoperatoriamente. Los factores de riesgo para su aparición son la RT previa, un tumor avanzado y una baja experiencia del cirujano en el procedimiento. La interposición de tejido en los defectos rectales sigue generando controversia. A pesar del cierre primario existe riesgo de fístula rectal, sobre todo en los casos de defectos mayores de 2 cm, RT previa o infiltración tumoral del recto.

Conclusiones: La lesión rectal es una complicación rara pero grave que puede complicar el postoperatorio de la prostatectomía radical.
IL-6 could regulate Th17/Treg cells to restore the local microenvironment of endometriosis
Authors: Jiang Jianfa , Feng Qing , He Sili 
Published: May 2022

IntroductionIn this study, we studied anti-IL-6 antibodies to treat endometriosis (EMS) by balancing Th17/Treg cells, providing a new basis for EMS research and treatment.Material and methodsThe rat EMS model was constructed to study the effect of anti-IL-6 on EMS. HE staining was performed to observe the lesions of the endometrium in rats. We have used anti-IL-6 to treat EMS rats. Then ELISA was used to measure the inflammatory factors IL-6, TGF-β and hormone estrogen levels in the rat serum. qRT-PCR and Western blot were used to measure estrogen receptor protein and apoptosis protein levels. Th17/Treg and CD163+/CD86+ ratios were determined by flow cytometry. CD34+ and CD163+ were measured by immunohistochemistry. TUNEL was performed to detect apoptosis in EMS lesions.ResultsThe elevated levels of IL-6, TGF-β and estrogen in EMS rats indicated successful modeling. The ratio of Th17/Treg was imbalanced and raised. The ratio of Th17/Treg in anti-IL-6 rats recovered. The expression of FOXP3 in anti-IL-6 rats increased, and ROR-γt expression was suppressed. Anti-IL-6 could increase the apoptosis of the cells in the lesion. The size of the lesion was reduced. The expression of VEGF in the microenvironment of the lesions of EMS rats decreased.ConclusionsIL-6 regulated Th17/Treg cells to restore the local microenvironment of EMS. Anti-IL-6 could regulate the immune microenvironment of EMS rats to alleviate the progression of EMS disease.
Propuestas de bienestar ¿con Estado de bienestar?
Authors: Ibisate Francisco Javier 
Published: May 2022

El neoliberalismo, uno de los tantos "neos" de fines de siglo, proclama entre sus objetivos la consecución del bienestar social. Empero, ¿es posible conseguirlo, primero, sin un Estado de bienestar, y segundo, en una sociedad insolidaria, no estructurada para el bienestar? El autor contesta a las dos preguntas, echando una mirada al desarrollo histórico del Estado de bienestar y a su contraposición con el esquema neoliberal, su antípoda.
ECA Estudios Centroamericanos, Vol. 51, No.576, 1996: 865-887.
Sikap Siswa Terhadap Pembelajaran Berbasis Online dilihat dari Berbagai Variabel
Authors: Cahyani Ariyani , Made Novi Suryanti Ni , Sukardi Sukardi 
Published: May 2022

Penelitian ini dilatar belakangi oleh perubahan yang terjadi pada proses pembelajaran karena pandemi covid-19. Perubahan yang terjadi adalah pembelajaran dilakukan secara online. Penelitian ini merupakan penelitian kuantitatif yang bertujuan untuk mengetahui perbedaan sikap siswa terhadap pembelajaran berbasis online dari berbagai variabel (jenis kelamin, usia dan kelas). Subjek penelitian adalah seluruh Siswa-siswi IPS di SMA Negeri 1 Gunungsari. Data dikumpulkan dengan membagikan questioner dengan bantuan google form. Analisis data dilakukan menggunakan statistik deskriptif dan komparatif. Hasil penelitian menunjukkan bahwa: ada perbedaan sikap siswa teradap pembelajaran berbasis online pada masa pandemi covid-19 dari berbagai variabel (jenis kelamin, usia, kelas). Siswa perempuan, usia 16 tahun dan kelas X memiliki persepsi yang lebih baik terhadap pembelajaran berbasis online. Implikasinya adalah pembelajaran berbasis online perlu memperhatikan perbedaan variable-variabel tersebut dalam implementasinya.
EFFECT OF THE WORK ENVIRONMENT ON EMPLOYEE PERFORMANCE IN THE BERINGIN DISTRICT OFFICE OF DELI SERDANG REGENCY
Authors: Pohan Fatimah , Angkat Rahimah 
Published: May 2022

Beringin District is one of the sub-districts in Deli Serdang Regency, has a Vision of "The realization of excellent service in Bringin District with Reliable Human Resource Support". This institution has the tagline that your satisfaction is our pride. But in its implementation there are still many obstacles that occur in the field so that it can hinder the desire of leaders in the sub-district in realizing that staff/employees can work effectively and efficiently. The purpose of this study is (1) To find out the condition of the work environment at the Beringin District Office of Deli Serdang Regency. (2) To find out the performance of employees at the Beringin District Office of Deli Serdang Regency. (3) To find out whether there is a significant influence between the work environment on the performance of employees in the Beringin District Office of Deli Serdang Regency. This research is quantitative research using simple regression analysis. The results showed that the work environment of the Beringin District Office of Deli Serdang Regency fell into the category of very good. The performance of employees of the Beringin District Office of Deli Serdang Regency falls into the category of very good. There is no positive and significant influence between the work environment and the performance of employees in the Beringin District Office of Deli Serdang Regency and those indicated by the correlation coefficient value (r) of 0.224 and the coefficient of determination (r2) of 0.05.
Mediasi Di BP4 Dalam Mencegah Perceraian
Authors: Paryadi Paryadi 
Published: May 2022

Tujuan penulisan ini mengurai faktor-faktor kurang efektifnya BP4 dan solusi urgensitasnya. Salah satu misi dari BP4 adalah mediasi untuk mencegah perceraian, tapi pelaksanaanya kurang efektif dalam mencegah perceraian. Penulisan ini menggunakan pendekatan normative. Hasil penelitian, peran BP4 saat ini belum efektif dalam menjalankan fungsinya, hal ini juga disebabkan oleh beberapa faktor (1) Posisi BP4 yang berdiri sendiri dan terpisah dengan Pengadilan Agama terkait dalam penyelesaian kasus perceraian (2) Kurangnya keperpihakan pemerintah kepada BP4 terutama dalam anggaran finansial(3) Kurangnya sosialisasi tentang fungsi BP4 kepada Masyarakat. Solusinya regulasi UU Perkawinan Nomor 1 Tahun 1974 Pasal 39 Tentang Perceraian harus di hadapan hakim Pengadilan Agama perlu diperlukan pembaharuan dengan taqshisul qadha, re-interprestasion dan syiasah syariyah. Sosialisasi ke masyarakat lebih intens tentang urgensitas BP4.
Epistemologi Hukum Islam Sir Muhammad Iqbal
Authors: Inayati Anindya Aryu 
Published: May 2022

ABSTRAK
Pembaruan Hukum Islam yang dilakukan Sir Muhammad Iqbal terjadi di awal abad ke-20. Melalui pemikirannya Sir Muhammad Iqbal menggagas pemisahan Negara Pakistan dari India dan menerapkan Hukum Islam serta menghidupkan kembali metodologi ijtihad yang sempat vacuum pada beberapa dekade sebelumnya. Penelitian ini mengupas tentang Epistemologi Hukum Islam Sir Muhammad Iqbal yang mencakup; Sumber Hukum Islam, Metodologi Hukum Islam, Validitas hukum Islam yang disampaikan Sir Muhammad Iqbal. Hasil dari Penelitian ini adalah bahwa sumber hukum Islam yaitu Al-Qur’an dan As-Sunnah, Metodologi Hukum Islam adalah ijtihad yang dimaknai oleh Muhammad Iqbal sebagai jantung dinamisasi hukum Islam dalam menjawab problematika zaman yang terus berkembang, dan Validitas Hukum Islam didapatkan dari kesepakatan Ulama (ijma’) dalam lembaga legislative Hukum Islam yang digagas oleh Sir Muhammad Iqbal.
Keywords: Epistemologi, Hukum Islam, Sumber Hukum, Metodologi, Validitas Hukum.
Do Fuel Treatments in U.S. National Forests Reduce Wildfire Suppression Costs and Property Damage?
Authors: Sánchez José J. , Loomis John , González-Cabán Armando , Rideout Douglas , Reich Robin 
Published: May 2022

ABSTRACTThis article tests two hypotheses on whether forest fuel reduction treatments (prescribed burning and mechanical methods) reduce wildfire suppression costs and property damages. Data were collected on fuel treatments, fire suppression costs, and property damage associated with wildfires in United States National Forests over a five-year period throughout the continental United States. The continental U.S. pooled data model results show that overall, prescribed burning reduces suppression cost and both fuel treatment types reduce property damages. Further analysis was done to separate the data into seven geographic regions of the United States. Results of the multiple regressions show that in California and the northern Rockies, mechanical fuel treatments reduce wildfire suppression costs, while only in California did prescribed burning reduce the cost. The second hypothesis tested is that fuel treatments, by making wildfires less damaging and easier to control, may reduce property damage. This hypothesis is generally confirmed for hectares treated with prescribed burning in four out of five geographic regions that had a significant coefficient on prescribed fire. Mechanical fuel reduction had a significant effect in reducing property damage in two of the three regions.
Efficacy of Immediate Post-Partum Intrauterine Contraceptive Device in a Tertiary Care Hospital
Authors: Rashid Shaista , Iqbal Asma , Naseeb Shazia 
Published: May 2022

Objective: To determine efficacy of post-partum intrauterine contraceptive device (IUCD) in women presenting to a tertiary hospital.To compare efficacy of post-partum Intrauterine device between vaginal Insertion and Intra-Cesarean Insertion. Material and Method: A Prospective, cross sectional study was conducted at Department of Gynecology and Obstetrics Unit III, Abbasi Shaheed Hospital, Karachi from Jan2020 to June, 2020.	Total 234 patients were included in this study. Patients fulfilling the inclusion criteria were enrolled in the study after taking Informed consent. Copper containing IUCD was inserted. Follow up was done at 6weeks and six months of delivery. All women were counseled to report missing threads, heavy vaginal bleeding, and vaginal discharge with pain in abdomen on each visit during follow-up. Abdominal, speculum and vaginal examinations was done. Efficacy was determined by the expulsion rate. Statistical analysis was done by SPSS Version 20. Results: Out of total insertions 103(44.01%) were intra caesarean and 131 (55.98%) IUCDs were placed after vaginal delivery. Symptoms of unusual vaginal discharge were reported by 28(11.9%) women, missing thread were reported by 67(28.5%), abdominal pain was reported by 92(39.2%) and heavy bleeding was reported by 44(18.8%) patients at follow-up. efficacy of vaginal insertion was 79(60.30%) and intra-cesarean insertion of PPIUCD was 65(63.10%). Conclusion: It can be concluded that PPIUCD in the field of postpartum family planning is a promising approach. Whatever may be the mode of delivery, PPIUCD is safe and effective. Keywords: Efficacy, Vaginal Insertion, Post-Partum Intrauterine Contraceptive Device, missing threads