bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of integrating mental health services within a prison setting
Authors: Kothari Radha , White Danielle , Craster Laura , Vicianova Eva , Dennard Sophie , Bailey Fiona , Kemp John , Tracy Derek K. , Sarkissian Natasha 
Published: February 2022

Purpose
In 1999, the national health service (NHS) was made responsible for the commissioning of prison health care. Mental health inreach teams (MHIT) were set up to mirror community mental health teams and provide secondary care to prisoners diagnosed with severe and enduring mental illnesses (SEMI). Since then, the provision of mental health care to prisoners without a diagnosis of a SEMI has been variable. A rapid review of NHS health care in prisons conducted by Public Health England (PHE) (2016) highlighted the need for provision to be more integrated and meet the needs of prisoners without a diagnosis of a SEMI. In response, an integrated mental health and substance misuse service was implemented within her majesty’s prison/young offenders institution Pentonville. This study aims to evaluate its impact and share lessons learned.

Design/methodology/approach
Routinely collected and anonymised data were reviewed for prisoners referred between 1 May 2018 and 31 December 2019. Data are presented on the quantity of referrals over time, and the type of support offered. Chi-square goodness of fit tests was conducted to determine whether the prisoners referred to the service were representative of the wider prison population in terms of age and ethnicity.

Findings
Referrals showed a general pattern of increase over time and were representative of the wider prison population in terms of age and ethnicity, indicating equitable access. Lessons learned are discussed. Demand for therapeutic and substance misuse services was higher than that for SEMIs. Notable was the high quantity of referrals which provides further evidence for the disparity between high need and limited provision within prison settings, particularly for therapeutic interventions.

Originality/value
To the best of the author’s knowledge, this is the first service evaluation of a recently implemented integrated and holistic model of prison mental health care in line with recommendations from PHE (2016).
The SAMR model as a framework for scaffolding online chat: a theoretical discussion of the SAMR model as a research method during these “interesting” times
Authors: Arantes Janine 
Published: February 2022

PurposeThe purpose of this paper is to explore the potential of the substitution, augmentation, modification and redefinition (SAMR) model as a research method via a project that aimed to investigate pre-service teachers' negotiation of data-rich environments.Design/methodology/approachThe project that underpins this paper saw the author working with a group of seven pre-service teachers through an online learning community on WhatsApp to explore their understanding of increasingly complex computational topics associated with the “Implications and Impacts” component of the digital technologies curriculum.FindingsThe knowledge and experiences of the pre-service teachers suggest considerable unexplored potential through the alignment of the SAMR model in online learning communities.Originality/valueThe paper draws attention to a range of opportunities associated with prompting discussion about increasingly complex topics in online learning communities. The adoption of the SAMR model offers a framework in education and the social sciences. It stresses the affordances enabled due to the personalized, ubiquitous and situated nature of the method. Unique contributions include the interpretive and critical approaches discussed in terms of research methods. The paper may be of value to researchers who are interested in a scaffolded means to engage with participants through an online learning community.
Deconstructing the microbial necromass continuum to inform soil carbon sequestration
Authors: Buckeridge Kate M. , Creamer Courtney , Whitaker Jeanette 
Published: February 2022

Abstract

Microbial necromass is a large, dynamic and persistent component of soil organic carbon, the dominant terrestrial carbon pool. Quantification of necromass carbon stocks and its susceptibility to global change is becoming standard practice in soil carbon research. However, the typical proxies used for necromass carbon do not reveal the dynamic nature of necromass carbon flows and transformations within soil that ultimately determine necromass persistence. In this review, we define and deconstruct four stages of the necromass continuum: production, recycling, stabilization and destabilization.

Current understanding of necromass dynamics is described for each continuum stage. We highlight recent advances, methodological limitations and knowledge gaps which need to be addressed to determine necromass pool sizes and transformations. We discuss the dominant controls on necromass process rates and aspects of soil microscale structure including biofilms and food web interactions. The relative importance of each stage of the continuum is then compared in contrasting ecosystems and for climate change drivers.

From the perspective of the continuum, we draw three conclusions to inform future research. First, controls on necromass persistence are more clearly defined when viewed through the lens of the continuum; second, destabilization is the least understood stage of the continuum with recycling also poorly evidenced outside of a few ecosystems; and third, the response of necromass process rates to climate change is unresolved for most continuum stages and ecosystems.

Future mechanistic research focused on the role of biotic and abiotic soil microscale structure in determining necromass process rates and the relative importance of organo–mineral and organo–organo interactions can inform necromass persistence in different climate change scenarios. Our review demonstrates that deconstructing the necromass continuum is key to predicting the vulnerability and persistence of necromass carbon in a changing world.

Read the free Plain Language Summary for this article on the Journal blog.
Context‐dependent variation in persistence of host populations in the face of disease
Authors: Hardy Bennett M. , Muths Erin , Koons David N. 
Published: February 2022

AbstractResearch Highlight: Valenzuela‐Sánchez, A., Azat, C., Cunningham, A. A., Delgado, S., Bacigalupe, L. D., Beltrand, J., Serrano, J. M., Sentenac, H., Haddow, N., Toledo, V., Schmidt, B. R., & Cayuela, H. (2022). Interpopulation differences in male reproductive effort drive the population dynamics of a host exposed to an emerging fungal pathogen. Journal of Animal Ecology, 00, 1– 12. https://doi.org/10.1111/1365‐2656.13603. Understanding the nuances of population persistence in the face of a stressor can help predict extinction risk and guide conservation actions. However, the exact mechanisms driving population stability may not always be known. In this paper, Valenzuela‐Sánchez et al. (2022) integrate long‐term mark–recapture data, focal measurements of reproductive effort, a population matrix model and inferences on life‐history variation to reveal differences in demographic response to disease in a susceptible frog species (Rhinoderma darwinii). Valenzuela‐Sánchez et al. found that demographic compensation via recruitment explained the positive population growth rate in their high disease prevalence population whereas the low disease prevalence population did not compensate and thus had decreasing population growth. Compensatory recruitment was likely due to the high probability of males brooding, and the high number of brooded larvae in the high prevalence population compared to low prevalence and disease‐free populations. Valenzuela‐Sánchez et al. also document faster generation times in the high prevalence population, which may indicate a faster life history that may be contributing to the population's ability to compensate for reduced survival. Lastly, the authors find a positive relationship between disease prevalence and the proportion of juveniles in a given population that suggest that there may be a threshold for disease prevalence that triggers increased reproductive effort. Altogether, their study provides novel support for increased reproductive effort as the pathway for compensatory recruitment leading to increasing population growth despite strong negative effects of disease on adult survival. Their results also caution the overgeneralization of the effects of stressors (e.g. disease) on population dynamics, where context‐dependent responses may differ among host populations of a given species.
The Production of Value Opinions by Specialized Valuers: Practical Sense and the Enactment of Judgment*
Authors: Plante Maude , Maire Sarah , Pucci Richard 
Published: February 2022

ABSTRACTThis article explores how valuers construct value opinions. Although some implications of outsourcing valuation to valuers for accounting purposes have been highlighted in the literature, we add a valuer perspective complementing the accountant's standpoint in order to obtain a fuller picture of these ramifications. Drawing on 62 interviews, we study the role of judgment in valuation and find that judgment is largely tied with the sensemaking of valuers. By examining the valuation activities of art and real estate valuers, we show that these specialized valuers follow a similar valuation process which allows them to grasp how to go on with valuation. This four‐phase process starts and ends by situating the opinion in its specific valuation context and is centered on iterations between researching, analyzing, and relativizing comparable data that may be adjusted to connect with a sense of what the value should be. Overall, judgment is shown to be enacted based on a practical sense of conducting valuation that includes a “gut feeling” of what represents a plausible value. This study suggests that the valuer's input should be recognized as situated, sense‐contingent, and vulnerable to the underlying politics and risks tied to providing an opinion. Our results also point to stark differences between how valuers approach the use of judgment compared to how judgment is typically exercised by accounting specialists.
Do Foreign Investors Monitor Managers in Merger and Acquisition? Evidence from China*
Authors: Zhao Xiaofang , Yang Hao , Xu Chao , Li Shiqing 
Published: February 2022

AbstractUsing foreign investors’ shareholding to proxy for foreign investors’ monitoring effect in the Chinese stock market, we find that those acquirers exhibit higher announcement returns with higher shareholding, and this effect is stronger when acquirers are private firms. We provide price efficiency and corporate governance channels through which foreign investors play a monitoring role in mergers and acquisitions. Finally, foreign investors decrease the likelihood that managers will conduct mergers in the future and significantly improve long‐run performance. Our study provides new insights into the real effects of foreign investors on acquisition performance and the economy.
Allergies and COVID‐19 vaccines: An ENDA/EAACI Position paper
Authors: Barbaud Annick , Garvey Lene Heise , Arcolaci Alessandra , Brockow Knut , Mori Francesca , Mayorga Cristobalina , Bonadonna Patrizia , Atanaskovic‐Markovic Marina , Moral Luis , Zanoni Giovanna , Pagani Mauro , Soria Angèle , Jošt Maja , Caubet Jean‐Christoph , Carmo Abreu , Mona Al‐Ahmad , Alvarez‐Perea Alberto , Bavbek Sevim , Benedetta Biagioni , Bilo M.Beatrice , Blanca‐López Natalia , Bogas Herrera Gádor , Buonomo Alessandro , Calogiuri Gianfranco , Carli Giulia , Cernadas Josefina , Cortellini Gabriele , Celik Gülfem , Demir Semra , Doña Inmaculada , Dursun Adile Berna , Eberlein Bernadette , Faria Emilia , Fernandes Bryan , Garcez Tomaz , Garcia‐Nunez Ignacio , Gawlik Radoslaw , Gelincik Asli , Gomes Eva , Gooi Jimmy H. C. , Grosber Martine , Gülen Theo , Hacard Florence , Hoarau Cyrille , Janson Christer , Johnston Sebastian L. , Joerg Lukas , Kepil Özdemir Seçil , Klimek Ludger , Košnik Mitja , Kowalski Marek L. , Kuyucu Semanur , Kvedariene Violeta , Laguna Jose Julio , Lombardo Carla , Marinho Susana , Merk Hans , Meucci Elisa , Morisset Martine , Munoz‐Cano Rosa , Murzilli Francesco , Nakonechna Alla , Popescu Florin‐Dan , Porebski Grzegorz , Radice Anna , Regateiro Frederico S. , Röckmann Heike , Romano Antonino , Sargur Ravishankar , Sastre Joaquin , Scherer Hofmeier Kathrin , Sedláčková Lenka , Sobotkova Marta , Terreehorst Ingrid , Treudler Regina , Walusiak‐Skorupa Jolanta , Wedi Bettina , Wöhrl Stefan , Zidarn Mihael , Zuberbier Torsten , Agache Ioana , Torres Maria J. 
Published: February 2022

AbstractBackgroundAnaphylaxis, which is rare, has been reported after COVID‐19 vaccination, but its management is not standardized.MethodMembers of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre‐vaccination screening and management of allergic reactions to COVID‐19 vaccines, and literature was analysed.ResultsNo death due to anaphylaxis to COVID‐19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine are excipients. The authors propose allergy evaluation of persons with the following histories: 1—anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2—anaphylaxis to oral/topical PEG containing products; 3—recurrent anaphylaxis of unknown cause; 4—suspected or confirmed allergy to any mRNA vaccine; and 5—confirmed allergy to PEG or derivatives. We recommend a prick‐to‐prick skin test with the left‐over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable.ConclusionsThese recommendations will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID‐19 vaccines and enable more people with history of allergy to be vaccinated.
Alpine altitude climate treatment for severe and uncontrolled asthma: An EAACI position paper
Authors: Fieten Karin B. , Drijver‐Messelink Marieke T. , Cogo Annalisa , Charpin Denis , Sokolowska Milena , Agache Ioana , Taborda‐Barata Luís Manuel , Eguiluz‐Gracia Ibon , Braunstahl Gerrit J. , Seys Sven F. , van den Berge Maarten , Bloch Konrad E. , Ulrich Silvia , Cardoso‐Vigueros Carlos , Kappen Jasper H. , Brinke Anneke ten , Koch Markus , Traidl‐Hoffmann Claudia , da Mata Pedro , Prins David J. , Pasmans Suzanne G. M. A. , Bendien Sarah , Rukhadze Maia , Shamji Mohamed H. , Couto Mariana , Oude Elberink Hanneke , Peroni Diego G. , Piacentini Giorgio , Weersink Els J. M. , Bonini Matteo , Rijssenbeek‐Nouwens Lucia H. M. , Akdis Cezmi A. 
Published: February 2022

AbstractCurrently available European Alpine Altitude Climate Treatment (AACT) programs combine the physical characteristics of altitude with the avoidance of environmental triggers in the alpine climate and a personalized multidisciplinary pulmonary rehabilitation approach. The reduced barometric pressure, oxygen pressure, and air density, the relatively low temperature and humidity, and the increased UV radiation at moderate altitude induce several physiological and immunological adaptation responses. The environmental characteristics of the alpine climate include reduced aeroallergens such as house dust mites (HDM), pollen, fungi, and less air pollution. These combined factors seem to have immunomodulatory effects controlling pathogenic inflammatory responses and favoring less neuro‐immune stress in patients with different asthma phenotypes. The extensive multidisciplinary treatment program may further contribute to the observed clinical improvement by AACT in asthma control and quality of life, fewer exacerbations and hospitalizations, reduced need for oral corticosteroids (OCS), improved lung function, decreased airway hyperresponsiveness (AHR), improved exercise tolerance, and improved sinonasal outcomes. Based on observational studies and expert opinion, AACT represents a valuable therapy for those patients irrespective of their asthma phenotype, who cannot achieve optimal control of their complex condition despite all the advances in medical science and treatment according to guidelines, and therefore run the risk of falling into a downward spiral of loss of physical and mental health. In the light of the observed rapid decrease in inflammation and immunomodulatory effects, AACT can be considered as a natural treatment that targets biological pathways.
Suitable indicator of heat stress for genetic evaluation of heat tolerance in Holstein cows in Japan
Authors: Ishida Satoka , Osawa Takefumi , Yamaguchi Shigeki , Yamazaki Takeshi , Hagiya Koichi 
Published: February 2022

AbstractOnly a few, principal, weather stations in Japanese prefectures have the daily humidity records required to calculate the temperature–humidity index (THI) as a dairy cow heat‐stress indicator. We compared three heat‐stress indices: (1) THI calculated from daily average temperature and daily relative humidity at a principal weather station (PTHI); (2) daily average temperature at each herd's closest local weather station (TEMP); and (3) THI calculated from daily average temperature at each herd's closest local weather station and daily relative humidity at the principal weather station (HTHI). We used daily records from 532 provincial weather stations and test‐day records of milk production from Days 6 to 305 post‐first‐calving in Holsteins to compare the indices as indicators of heat‐stress effects on milk yield and somatic cell score (SCS). The models used the BLUPF90 package to analyze the effects of herd–year, calving age, days in milk, and PTHI, TEMP, or HTHI. We estimated each model's mean square error (MSE) and compared suitabilities among indices for each trait. TEMP heat‐stress thresholds were ~18°C (milk yield) and 15–20°C (SCS). The MSE of the HTHI model was the smallest, but no significant differences were found among the indices for milk yield.
A systematic literature review and meta‐analysis of community pharmacist‐led interventions to optimise the use of antibiotics
Authors: Lambert Maarten , Smit Chloé C. H. , De Vos Stijn , Benko Ria , Llor Carl , Paget W. John , Briant Kathryn , Pont Lisa , Van Dijk Liset , Taxis Katja 
Published: February 2022

AimsThe aim of this systematic review is to assess the effects of community pharmacist‐led interventions to optimise the use of antibiotics and identify which interventions are most effective.MethodsThis review was conducted according to the PRISMA guidelines (PROSPERO: CRD42020188552). PubMed, EMBASE and the Cochrane Central Register of Controlled Trials were searched for (randomised) controlled trials. Included interventions were required to target antibiotic use, be set in the community pharmacy context, and be pharmacist‐led. Primary outcomes were quality of antibiotic supply and adverse effects while secondary outcomes included patient‐reported outcomes. Risk of bias was assessed using the ‘Cochrane suggested risk of bias criteria’ and narrative synthesis of primary outcomes conducted.ResultsSeventeen studies were included covering in total 3822 patients (mean age 45.6 years, 61.9% female). Most studies used educational interventions. Three studies reported on primary outcomes, 12 on secondary outcomes and two on both. Three studies reported improvements in quality of dispensing, interventions led to more intensive symptom assessment (up to 30% more advice given) and a reduction of over‐the‐counter supply up to 53%. Three studies led to higher consumer satisfaction, effects on adherence from nine studies were mixed (risk difference 0.04 [−0.02, 0.10]). All studies had unclear or high risks of bias across at least one domain, with large heterogeneity between studies.ConclusionsOur review suggests some positive results from pharmacist‐led interventions, but the interventions do not seem sufficiently effective as currently implemented. This review should be interpreted as exploratory research, as more high‐quality research is needed.
Population pharmacokinetics of tanezumab following intravenous or subcutaneous administration to patients with osteoarthritis or chronic low back pain
Authors: Shoji Satoshi , Suzuki Akiyuki , Gaitonde Puneet , Cai Chun‐Hua , Marshall Scott 
Published: February 2022

AimsDescribe population pharmacokinetics of intravenous (IV) and subcutaneous (SC) tanezumab across Phase 2b/3 studies of osteoarthritis and chronic low back pain.MethodsData from 10 studies of IV or SC tanezumab (2.5–20 mg every 8 wk for up to 56 wk) were included in a multistep analysis. In Step 1, a 2‐compartment model with linear and nonlinear elimination (based on prior analysis of pre‐2015 IV osteoarthritis studies) was expanded to include other pre‐2015 studies. In Step 2, post‐2015 SC studies were combined into the model. Steps 3 and 4 evaluated impact of baseline nerve growth factor (NGF) and treatment‐emergent anti‐drug antibodies (TE ADA).ResultsSC bioavailability was estimated at 62–76%. The key disposition parameters CL, Vc, Vp and KM were estimated to be 0.133 L d−1, 2.6 L, 1.77 L and 31.2 μg L−1, respectively. Plasma tanezumab concentration was predicted to reach Cmax at 8.9–11.2 days following single and multiple SC administration in typical patients within the dose range of SC Phase 3 studies (2.5–10 mg every 8 wk). Exposure of a typical patient was similar between IV and SC for the second part of the dosing interval (wk 4–8). Covariates selected on the absorption parameters were weight, age, sex and injection site. Baseline NGF had minimal effect on maximum elimination capacity and TE ADA status was associated with slightly higher tanezumab clearance (6–7%).ConclusionOur model adequately described plasma tanezumab concentration vs. time following IV or SC administration. Weight was the most influential covariate with respect to absorption of tanezumab in comparison to patient population (osteoarthritis and chronic low back pain) or other demographics. There was no clinically relevant effect of baseline NGF or TE ADA on tanezumab PK.
Athena: Speciality Certificate Examination case for general dermatology and dermatology in primary healthcare
Authors: Santhosh Parvathy , George Mamatha 
Published: February 2022

AbstractA 25-year-old man presented with a 3-year history of pruritic, hyperpigmented, scaly, fissured plaques over the dorsa of the feet, which had not responded to topical steroids.