bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bullous pemphigoid anti-BP180-NC16A autoantibody reactivity in healthy individuals is associated with marked hypovitaminosis D and Th2-like cytokine predominance
Authors: Tukaj Stefan , Bieber Katja , Prüßmann Wiebke , Prüßmann Jasper N. , Schmidt Enno , Zillikens Detlef , Ludwig Ralf J. , Kasperkiewicz Michael 
Published: August 2022

AbstractAutoimmune bullous disease autoantibodies, particularly including bullous pemphigoid (BP)-related anti-BP180-NC16A IgG, have been reported in a small subset of healthy individuals, but information about associated factors is lacking. We hypothesized that an abnormal status of immunomodulatory vitamin D could play a role in anti-BP180-NC16A autoantibody reactivity in healthy persons. In addition, we aimed to evaluate the cytokine profile associated with these autoantibodies. Plasma samples from 34 anti-BP180-NC16A IgG-reactive and 85 anti-BP180-NC16A IgG-negative healthy blood donors were tested for levels of 25-hydroxyvitamin D [25(OH)D] and a wide range of cytokines (IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-13, IL-17A, IL-17F, IL-21, IL-22, IFN-γ, and TNF-α). We observed that anti-BP180-NC16A IgG-reactive healthy subjects had significantly lower plasma 25(OH)D levels and about a two-fold higher rate of vitamin D deficiency (< 20 ng/ml) compared to anti-BP180-NC16A IgG-negative healthy persons. In addition, anti-BP180-NC16A IgG-positive samples were characterized by significantly higher levels of IL-2, IL-5, IL-9, IL-10, and IL-13 which were, however, not significantly associated with the vitamin D levels. Our results indicate that healthy individuals with BP autoantibody reactivity share similarities with BP patients regarding the vitamin D status and cytokine profile (i.e., marked hypovitaminosis D and Th2 predominance), which may have pathophysiologic implications.
Dancing to a different tune: changing reproductive seasonality in an introduced chital deer population
Authors: Kelly Catherine L. , Schwarzkopf Lin , Gordon Iain J. , Pople Anthony , Kelly David L. , Hirsch Ben T. 
Published: August 2022

AbstractMale and female reproductive behaviour is typically synchronised. In species such as those in the familyCervidae, reproductive timing is often cued by photoperiod, although in females, it can be dependent on body condition. When a species is introduced to a novel environment, the environment changes, or responses of the sexes to such cues differ, asynchronous reproductive behaviour between males and females may occur. We investigated the seasonality of reproductive behaviour in introduced chital deer in northern Queensland by examining male antler phase in relation to female conception rates. We then analysed the influence of different variables likely to affect the timing of male and female reproductive physiology. The lowest percentage of chital in hard antler in any 1 month in this study was 35% (Fig. 1), but the average value was closer to 50%, thus there was a seasonal peak in antler phase linked with photoperiod. Females conceived at any time of year, but were strongly influenced by the amount of rainfall 3 months prior to conception. This resulted in varying conception peaks year-to-year that often did not correspond to the male’s peak in hard antler. In this system, a proportion of males and females were physiologically and behaviourally ready to mate at any time of the year. We predict that differences in the timing of the peaks between the males and females will lead to increased reproductive skew (variation in reproductive success among individual males). This pattern may select for different mating strategies or physiological mechanisms to increase reproductive success.
Attendance in a national screening program for diabetic retinopathy: a population-based study of 205,970 patients
Authors: Thykjær Anne Suhr , Andersen N. , Bek T. , Heegaard S. , Hajari J. , Laugesen C. S. , Möller S. , Pedersen F. N. , Rosengaard L. , Schielke K. C. , Kawasaki R. , Højlund K. , Rubin K. H. , Stokholm L. , Grauslund J. 
Published: August 2022

Abstract
Aims
A nationwide diabetic retinopathy (DR) screening program has been established in Denmark since 2013. We aimed to perform an evaluation of adherence to DR screenings and to examine whether non-adherence was correlated to DR progression.

Methods
The population consisted of a register-based cohort, who participated in the screening program from 2013 to 2018. We analyzed age, gender, marital status, DR level (International Clinical DR severity scale, none, mild-, moderate-, severe non-proliferative DR (NPDR) and proliferative DR (PDR)), comorbidities and socioeconomic factors. The attendance pattern of patients was grouped as either timely (no delays > 33%), delayed (delays > 33%) or one-time attendance (unexplained).

Results
We included 205,970 patients with 591,136 screenings. Rates of timely, delayed and one-time attendance were 53.0%, 35.5% and 11.5%, respectively. DR level at baseline was associated with delays (mild-, moderate-, severe NPDR and PDR) and one-time attendance (moderate-, severe NPDR and PDR) with relative risk ratios (RRR) of 1.68, 2.27, 3.14, 2.44 and 1.18, 2.07, 1.26, respectively (P < 0.05). Delays at previous screenings were associated with progression to severe NPDR or PDR (hazard ratio (HR) 2.27, 6.25 and 12.84 for 1, 2 and 3+ delays, respectively). Any given delay doubled the risk of progression (HR 2.28).

Conclusions
In a national cohort of 205,970 patients, almost half of the patients attended DR screening later than scheduled or dropped out after first screening episode. This was, in particular, true for patients with any levels of DR at baseline. DR progression in patients with delayed attendance, increased with the number of missed appointments.
Increased serum 12-hydroxyeicosatetraenoic acid levels are correlated with an increased risk of diabetic retinopathy in both children and adults with diabetes
Authors: Chen Shuli , Qian Yu , Lin Qiurong , Chen Zhangling , Xiang Zhaoyu , Cui Lipu , Sun Jiaqi , Qin Xinran , Xu Yi , Lu Lina , Zou Haidong 
Published: August 2022

Abstract
Purpose
To investigate the relationship between serum 12-Hydroxyeicosatetraenoic acid (12-HETE) and diabetic retinopathy (DR) in children with type 1 diabetes mellitus (T1DM) and adults with type 2 diabetes mellitus (T2DM).

Methods
Children from the Shanghai Children and Adolescent Diabetes Eye (SCADE) study and adults from the Shanghai Cohort Study of Diabetic Eye Disease (SCODE) were examined in 2021. Serum 12-HETE levels were detected and compared. Multivariate logistic regression was used to analyze the relationship between 12-HETE and the rate of DR in diabetic patients.

Results
The child study included 4 patients with new-onset DR and 24 patients with T1DM without DR. In children with T1DM, the 12-HETE level was significantly higher in those with DR (P = 0.003). The adult study had two sets, for testing and verification. The test set included 28 patients with new-onset DR and 24 T2DM patients with a course of ≥ 20 years who had never developed DR. The verification set included 41 patients with DR, 50 patients without DR and 50 healthy controls. In the adult test set, the 12-HETE level was significantly higher in patients with DR than in those with T2DM without DR (P = 0.003). In the verification set, the 12-HETE level of patients with DR was significantly higher than that of patients without DR (P < 0.0001) and the healthy controls (P < 0.0001). Multivariate logistic regression indicated that 12-HETE was independently associated with DR in both children (odds ratio [OR] 1.06, 95% confidence interval [CI] 1.00–1.13, P = 0.041) and adults (test set [OR 9.26, 95% CI 1.77–48.59, P = 0.008], verification set [OR 10.49, 95% CI 3.23–34.05, P < 0.001]).

Conclusion
Higher serum 12-HETE levels are positively correlated with an increased risk of DR in children with T1DM and adults with T2DM.
Passive social sensing with smartphones: a systematic review
Authors: Zhang Heng , Ibrahim Ahmed , Parsia Bijan , Poliakoff Ellen , Harper Simon 
Published: August 2022

AbstractSmartphones are widely used hubs of personal communication. With their many sensors, they are capable of monitoring social behaviours. Calls, messages, application usage and even face-to-face conversations can be captured by smartphones. These data are then used to study psychological, behavioural and clinical issues, thus providing an objective and continuous perspective on people’s social lives. However, compared with questionnaires, researchers are unfamiliar with the potential and challenges of smartphone social sensing. Moreover, previous studies utilised their own instruments and strategies, which caused repetitive work and threatened the generalisability or validity of results. To fill the gap between conceptual and empirical knowledge, we conducted a systematic review on empirical studies that applied passive smartphone social sensing. Forty-seven eligible articles were retrieved from 2,741 results from five major databases. A paradigm of reviewed studies was extracted, and the comprehensive procedures of passive smartphone social sensing, including applied sensors, experiment length and data analysis methods, were also summarised. This information can provide a general reference for researchers interested in applying passive smartphone social sensing. Benefits such as ubiquitousness, unobtrusiveness and personalisability and challenges such as privacy, accuracy and methodology were also reported. Moreover, fundamental research on reasonable sensor frequency choices, standardising features and implementing state-of-the-art technologies is recommended to enhance passive smartphone social sensing usability.
Interactive Multimedia Reporting Technical Considerations: HIMSS-SIIM Collaborative White Paper
Authors: Berkowitz Seth J. , Kwan David , Cornish Toby C. , Silver Elliot L. , Thullner Karen S. , Aisen Alex , Bui Marilyn M. , Clark Shawn D. , Clunie David A. , Eid Monief , Hartman Douglas J. , Ho Kinson , Leontiev Andrei , Luviano Damien M. , O’Toole Peter E. , Parwani Anil V. , Pereira Nielsen S. , Rotemberg Veronica , Vining David J. , Gaskin Cree M. , Roth Christopher J. , Folio Les R. 
Published: August 2022

AbstractDespite technological advances in the analysis of digital images for medical consultations, many health information systems lack the ability to correlate textual descriptions of image findings linked to the actual images. Images and reports often reside in separate silos in the medical record throughout the process of image viewing, report authoring, and report consumption. Forward-thinking centers and early adopters have created interactive reports with multimedia elements and embedded hyperlinks in reports that connect the narrative text with the related source images and measurements. Most of these solutions rely on proprietary single-vendor systems for viewing and reporting in the absence of any encompassing industry standards to facilitate interoperability with the electronic health record (EHR) and other systems. International standards have enabled the digitization of image acquisition, storage, viewing, and structured reporting. These provide the foundation to discuss enhanced reporting. Lessons learned in the digital transformation of radiology and pathology can serve as a basis for interactive multimedia reporting (IMR) across image-centric medical specialties. This paper describes the standard-based infrastructure and communications to fulfill recently defined clinical requirements through a consensus from an international workgroup of multidisciplinary medical specialists, informaticists, and industry participants. These efforts have led toward the development of an Integrating the Healthcare Enterprise (IHE) profile that will serve as a foundation for interoperable interactive multimedia reporting.
A survey on machine learning in array databases
Authors: Villarroya Sebastián , Baumann Peter 
Published: August 2022

AbstractThis paper provides an in-depth survey on the integration of machine learning and array databases. First,machine learning support in modern database management systems is introduced. From straightforward implementations of linear algebra operations in SQL to machine learning capabilities of specialized database managers designed to process specific types of data, a number of different approaches are overviewed. Then, the paper covers the database features already implemented in current machine learning systems. Features such as rewriting, compression, and caching allow users to implement more efficient machine learning applications. The underlying linear algebra computations in some of the most used machine learning algorithms are studied in order to determine which linear algebra operations should be efficiently implemented by array databases. An exhaustive overview of array data and relevant array database managers is also provided. Those database features that have been proven of special importance for efficient execution of machine learning algorithms are analyzed in detail for each relevant array database management system. Finally, current state of array databases capabilities for machine learning implementation is shown through two example implementations in Rasdaman and SciDB.
Gnomes, Gnature, and the “Gnifty Gnomobile”: Elemental Spirits, Deforestation and Energy Systems in Transition in Upton Sinclair’s The Gnomobile
Authors: Fimi Dimitra 
Published: August 2022

AbstractUpton Sinclair’s only children’s book, The Gnomobile: A Gnice Gnew Gnarrative with Gnonsense, but Gnothing Gnaughty (1936), follows the adventures of a 12-year-old girl, Elizabeth, her young uncle Rodney, and their encounter with the last two Gnomes (Bobo, and his grandfather Glogo) of the Californian redwoods. The Gnomes and their kin are victims of the lumber business and deforestation which, ironically, is the source of the wealth of Rodney and Elizabeth’s family. The four set off in Rodney’s car, now dubbed the “Gnomobile”, in a quest to locate any other surviving Gnome communities in remaining forests across the entire country. This fast-paced novel brings together elements of “little people” folklore, children’s environmental writing, and Sinclair’s signature critique of capitalism and celebrity culture. But at the same time, the story revels in the pleasures of technological progress, relies on the affordances of speed and efficiency of the automobile, and seems to portray the desirability (as well as inevitability) of the exuberance of technological “progress”, not only in human culture, but in Gnomish social evolution too. This article approaches The Gnomobile from the perspectives of energy humanities and environmental studies, while also suggesting thematic parallels between The Gnomobile and Sinclair’s much better-known realist novel Oil! (1927).
Street Photography Ethics
Authors: Hadley John 
Published: August 2022

AbstractIn this paper I examine the ethics of street photography. I firstly discuss the close-up ‘in-your-face’ style street photography made famous by American photographer, Bruce Gilden. In close-up street photography, the proximity of the camera to the subject and the element of surprise work in tandem to produce a striking and evocative picture. Close-up street photography is shown to be ethically contentious on wellbeing-related and autonomy-related grounds. I next examine the more orthodox ‘respectable distance’ kind of street photography. In orthodox street photography, the photographer positions the camera some distance away from a nonconsenting subject that may or may not be aware a picture is to be taken. The main ethical problem with this form of street photography relates to the subject’s vanity and sense of self. When street photographers produce and publish images without the consent of subjects, they express their own creative freedom at the expense of the subject’s right to editorial control. I discuss the scope and potentially demanding practical implications of a right to editorial control. To conclude, I offer a workable solution to the ethical dilemma facing street photographers and discuss the implications of smart phones and photo-sharing social media platforms.
The effect of constituent particles on the tear resistance of three 6000-series aluminium alloys
Authors: Qvale Kristin , Thomesen Susanne , Hopperstad Odd Sture , Børvik Tore 
Published: August 2022

AbstractThis paper investigates the tear resistance of three cast and homogenized 6000-series alloys, namely AA6061, AA6063 and AA6110, all in temper T6, by means of Kahn tear tests. Of each alloy one commercial version and one tailor-made version were studied. The tailor-made alloys were designed to have approximately three times higher content of constituent particles by increasing the amount of Fe and Si in the chemical composition. The aim was to study in what way a higher constituent-particle content affects the tear resistance and properties of the alloys. The research showed that the unit initiation and propagation energies measured from the Kahn tear tests are markedly reduced when the constituent-particle content is increased, and that the tear resistance is reduced by a higher fraction than the failure strain of the smooth tensile tests. No major differences in the fracture mode and the fracture mechanisms between the alloys with normal and with high constituent-particle content were revealed by the use of computed tomography scanning or scanning electron microscopy imaging. It was concluded for the alloys studied that the increased content of constituent particles had a significant effect on the tear resistance, while the fracture mode and mechanisms remained the same.
A Review on Applications of Time-Lapse Electrical Resistivity Tomography Over the Last 30 Years : Perspectives for Mining Waste Monitoring
Authors: Dimech Adrien , Cheng LiZhen , Chouteau Michel , Chambers Jonathan , Uhlemann Sebastian , Wilkinson Paul , Meldrum Philip , Mary Benjamin , Fabien-Ouellet Gabriel , Isabelle Anne 
Published: August 2022

AbstractMining operations generate large amounts of wastes which are usually stored into large-scale storage facilities which pose major environmental concerns and must be properly monitored to manage the risk of catastrophic failures and also to control the generation of contaminated mine drainage. In this context, non-invasive monitoring techniques such as time-lapse electrical resistivity tomography (TL-ERT) are promising since they provide large-scale subsurface information that complements surface observations (walkover, aerial photogrammetry or remote sensing) and traditional monitoring tools, which often sample a tiny proportion of the mining waste storage facilities. The purposes of this review are as follows: (i) to understand the current state of research on TL-ERT for various applications; (ii) to create a reference library for future research on TL-ERT and geoelectrical monitoring mining waste; and (iii) to identify promising areas of development and future research needs on this issue according to our experience. This review describes the theoretical basis of geoelectrical monitoring and provides an overview of TL-ERT applications and developments over the last 30 years from a database of over 650 case studies, not limited to mining operations (e.g., landslide, permafrost). In particular, the review focuses on the applications of ERT for mining waste characterization and monitoring and a database of 150 case studies is used to identify promising applications for long-term autonomous geoelectrical monitoring of the geotechnical and geochemical stability of mining wastes. Potential challenges that could emerge from a broader adoption of TL-ERT monitoring for mining wastes are discussed. The review also considers recent advances in instrumentation, data acquisition, processing and interpretation for long-term monitoring and draws future research perspectives and promising avenues which could help improve the design and accuracy of future geoelectric monitoring programs in mining wastes.
Career counsellors’ professional agency when working with migrants
Authors: Kekki Miika , Linde Jonna 
Published: August 2022

AbstractThis article analyses the professional agency of counsellors working with migrants. Using Bernstein’s concepts of classification and framing, our thematic analysis draws on interviews with career counsellors from both Finland and Sweden. The results highlight a need for counsellors to recognise the differences in situations of students with migrant backgrounds and their native peers and adjust their counselling accordingly. They also indicate that counsellors struggle with implementation of the core of their professional agency as a result of societal domination of the counselling agenda and indicate a need for more collective, society-level challenging of this agenda.
A revised multi-tissue, multi-platform epigenetic clock model for methylation array data
Authors: Pipek Orsolya Anna , Csabai István 
Published: August 2022

AbstractEpigenetic changes have long been investigated in association with the process of aging in humans. DNA methylation has been extensively used as a surrogate measure of biological age and correlations between “DNA methylation age” and chronological age have been established. A wide variety of epigenetic clocks has been designed to predict age in different tissues and on data obtained from different methylation platforms. We aimed to extend the scope of one of the most used epigenetic age predictors, the Horvath pan-tissue epigenetic clock, to improve its accuracy on data acquired from the latest Illumina methylation platform (BeadChip EPIC). We present three models trained on close to 6,000 samples of various source tissues and platforms and demonstrate their superior performance (Pearson correlation (r) = 0.917–0.921 and median absolute error (MAE) = 3.60–3.85 years) compared to the original model (r = 0.880 and MAE = 5.13 years) on a test set of more than 4,000 samples. The gain in accuracy was especially pronounced on EPIC array data (r = 0.89, MAE = 3.54 years vs. r = 0.83, MAE = 6.09 years), which was not available at the time when the original model was created. Our updated epigenetic clocks predict chronological age with great precision in an independent test cohort of samples on multiple tissue types and data platforms. Two of the three presented models exclusively use the covariates of the original epigenetic clock, albeit with different coefficients, allowing for straightforward adaptation for prefiltered datasets previously processed with the original predictor.
Positive solutions to the nonlinear reactor model by variational iteration method
Authors: Kaźmierczak Anna , Orpel Aleksandra 
Published: August 2022

AbstractWe investigate the equation of the form $$(a(t)u^{\prime }(t))^{\prime }+Aa(t)u^{\prime }(t)+f(t,u(t))=0$$

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, which is associated with the classical Markus and Amundson’s model. The main goal of this paper is to show that He’s variational iteration method appears to be very useful in deriving formulas of approximate solutions and gives better results that other methods. This fact will be illustrated by a few representative examples of BVPs of the aforementioned type. The numerical part is preceded by the theoretical results devoted to existence of positive solutions to this problem and their properties. We also discuss the dependence of the solutions on functional parameters. Our approach allows us to consider sublinear and superlinear cases in which f can be singular with respect to the first variable.