bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast Metastasis Of Signet Ring Cell Carcinoma From The Colon: A Case Report
Authors: Wang Xiao , Lu Yanwei 
Published: March 2022

Abstract
Background: Colon cancer is one of the most common diagnosed malignancies. Although the use of surgery, chemotherapy, radiotherapy, targeted therapy, immunotherapy and other comprehensive treatment, distant metastasis is still one of the main causes for dying of colon cancer. The common metastatic site of colon cancer is liver, lung and bone. In this article, we report a rare case of breast metastasis of signet ring cell carcinoma from the colon. Case Presentation: A 44-year-old woman was diagnosed with colon cancer and received a radical surgery of colon cancer in 2019. Combined with postoperative pathological and CT images, a diagnosis of cT3N2M0 mucinous adenocarcinoma of colon (according to AJCC cancer staging manual, Version 8) was established. Adjuvant chemotherapy (XELOX: oxaliplatin 130 mg/m2 on day 1 plus capecitabine 1000 mg/m2 twice daily on days 1 to 14 every 3 weeks for 18 weeks) was performed followed by surgical resection. 14 months later, the patient received mastectomy for breast mass, which was diagnosed pathologically as metastasis of signet ring cell carcinoma from the colon. XELOX chemotherapy regimen (oxaliplatin 130 mg/m2 on day 1 plus capecitabine 1000 mg/m2 twice daily on days 1 to 14 every 3 weeks for 24 weeks) combined with bevacizumab (7.5mg/kg on day 1) were used after the mastectomy. The patient was stable disease according to her last examination (RECIST criteria).Conclusion: It is rare to report a patient diagnosed with colon cancer which metastasis to breast. We hope to increase treatment experience for patients with this rare metastasis.
Precision Public Health Initiatives in Cancer: Proceedings from the Transdisciplinary Conference for Future Leaders in Precision Public Health
Authors: Allen Caitlin G. 
Published: March 2022

Abstract
Background.
Precision public health is an emergent field that requires transdisciplinary collaborations that leverage innovative approaches to improve population health. These opportunities have inspired a new generation of precision public health researchers. Despite burgeoning interest in precision public health, there are limited opportunities for researchers to convene and continue the momentum of this field.
Methods.
The Transdisciplinary Conference for Future Leaders in Precision Public Health was the first event to bring together international researchers and practitioners to learn, network, and agenda set for the future of the field. The conference took place virtually on October 14 and 15, 2021.
Results.
The conference spanned two days and featured a keynote address, speakers from public health disciplines who are international leaders in precision-based research, networking opportunities, a poster session, and productive research agenda setting activities.
Conclusion.
The conference was a critical first step to creating a shared international conversation about precision public health, especially among early-stage investigators. This allows us to continue to build individual skills and international collaborations, and to grow the field of precision public health.
Co-assembled Perylene/GO Photosensitive Heterobilayer for Efficient Neuromorphics
Authors: Zhang Heshan , Dong Xue-Mei , Zhang Zi-Cheng , Zhang Ze-Pu , Ban Chaoyi , Zhou Zhe , Song Cheng , Yan Shiqi , Xin Qian , Liu Juqing , Li Yin-Xiang , Huang Wei 
Published: March 2022

Abstract
Neuromorphic electronics, which use artificial photosensitive synapses, can emulate biological nervous systems with in-memory sensing and computing abilities. Benefiting from multiple intra/interactions and strong light-matter coupling, two-dimensional heterostructures are promising synaptic materials for photonic synapses. Two primary strategies, including chemical vapor deposition and physical stacking, have been developed for layered heterostructures, but large-scale growth control over wet-chemical synthesis with comprehensive efficiency remains elusive. Here we demonstrate an interfacial coassembly heterobilayer films from perylene and graphene oxide (GO) precursors, which are spontaneously formed at the interface, with highly uniform bilayer structure of single-crystal perylene and well-stacked GO over centimeters in size. The planar heterostructure device exhibits an ultrahigh specific detectivity of 5.01×1016 Jones and ultralow energy consumption of 10− 9 W as well as broadband photoperception from 365 to 1550 nm. Moreover, the device shows extraordinary photonic synaptic behaviors with a paired-pulse facilitation (PPF) index of 214% in neuroplasticity, and the heterosynapse array has the capability of information reinforcement learning and recognition.
Real-Time Gait Phase Detection on Wearable Devices for Unsupervised Gait
Authors: Wu Jiaen , Becsek Barna , Schaer Alessandro , Maurenbrecher Henrik , Chatzipirpiridis George , Ergeneman Olgac , Pané Salvador , Torun Hamdi , Nelson Bradley 
Published: March 2022

Abstract
Detecting gait phases unobtrusively and reliably in real-time for long-term unsupervised walking is important for clinical gait rehabilitation and early diagnosis of neurological diseases. Due to hardware limitations in wearable devices, real-time gait phase detection remains a challenge for unsupervised mobility assessment. In this work, a hybrid algorithm combining a reduced support vector machine (RSVM) and a finite state machine (FSM) is developed to address this. The RSVM is developed by reducing the SVM model size for real-time applications through a novel technique based on K-means clustering, and the FSM validates predictions and corrects misclassifications of RSVM. With the proposed algorithm, the model size is reduced by 88%, and the computation time is reduced by a factor of 36, with only a minor degradation in performance. The real-time classification performance of the algorithm is evaluated by twenty healthy subjects walking outdoors with unsupervised gait. The proposed algorithm demonstrated promising real-time performance, with the accuracy, sensitivity, and specificity of 91.51%, 91.70%, 95.77% across all test subjects.
Field-tuned chiral transport in charge-ordered CsV3Sb5
Authors: Guo Chunyu , Putzke Carsten , Konyzheva Sofia , Huang Xiangwei , Gutierrez-Amigo Martin , Errea Ion , Chen Dong , Vergnior Maia , Felser Claudia , Fischer Mark , Neupert Titus , Moll Philip 
Published: March 2022

Abstract
When conductors differ from their mirror image, their chirality is reflected in the electron states and their dynamics. Conventionally, mirror symmetries are broken by the atomic structure of crystals and imprint their low symmetry onto the itinerant electron states. Unusual transport properties are a hallmark of chiral crystals, such as a non-linear electric response known as electronic magneto-chiral ansiotropy (eMChA). Here we report such a transport signature in the centro-symmetric layered Kagome metal CsV3Sb5, observed via second harmonic generation under magnetic field. We observe the signal in a charge-ordered phase of the material, which has been proposed to be a loop-current phase with spontaneously broken mirror symmetries. While charge ordering sets in at TCDW ≈ 94 K, the eMChA transport becomes significant only at temperatures below T'≈ 34 K, indicative of further evolutions of this ordered phase upon lowering the temperature. Crucially, we demonstrate that the nonlinear magnetotransport can be switched by small out-of-plane fields, in accordance with recent tunneling microscopy experiments. Unlike structurally chiral materials, our results demonstrate how the electronic chirality of a metal can be tuned and even abruptly switched by small changes in magnetic fields alone -- a prerequisite for their applications in chiral electronics.
Assessment of Electrocardiogram Interpretation Competency among Health Professional staff and Students of Ardabil University of Medical Sciences: A Multidisciplinary Study
Authors: Amini Keyvan , mirzaei alireza , Hosseini Mirtohid , Zandian Hamed , Azizpour Islam , Haghi Yagoob 
Published: March 2022

Abstract
BackgroundElectrocardiogram (ECG) interpretation is a core clinical skill that helps to rapid diagnosis of potentially life-threatening diseases. Misinterpretation of the electrocardiogram can lead to inappropriate clinical decisions with adverse outcomes. The main aim of this survey was to assess the competency of electrocardiogram interpretation and related factors among Health Professional staff and Students of Ardabil University of Medical Sciences. MethodsThis descriptive cross-sectional study included 323 staff and students of Ardabil University of Medical Sciences in northwestern Iran. Data were collected randomly from November to January 1400 using the Badell-Coll ECG Interpretation Competency Questionnaire and analyzed using SPSS V.14. Statistical analysis included descriptive statistics, independent t-test, ANOVA, Pearson correlation coefficient and multiple linear regression.ResultsThe results showed that the mean and standard deviation of electrocardiogram interpretation competency of health professional staff and students was 5.13 ± 2.25 (maximum score = 10). The large number of participants wasn't able to identify normal sinus rhythm (n = 251, 77.3%), acute myocardial infarction (n = 206, 63.8%) and pathological Q (n = 201, 62.2%). The results of multiple linear regression showed that the variables of education level, self-assessment of electrocardiogram interpretation competence, work experience, and type of hospital were able to predict the competence of ECG interpretation in participants.ConclusionsOur findings showed that the participants' level of electrocardiogram interpretation competency was low. Hence, regular, standard training and education are recommended. Also, managers and educators of the health system should consider the role of positive self-assessment and exposure to ECG interpretation in improving the competence of staff and students to interpret ECG.
Insights into regulating mechanism of mutagenesis strains of Elizabethkingia meningoseptica sp. F2 by omics analysis.
Authors: Yang Qiang , zheng zhiming , Wang Peng , Wang Li , Wang Han , Zhang Mengxue , Zhao Genhai 
Published: March 2022

Abstract
Vitamin K2 plays an important role in electron transport, blood coagulation, and calcium homeostasis; therefore, researchers have attempted to improve vitamin K2 production in Elizabethkingia meningoseptica. Our previous work revealed that gradient radiation, breeding, and culture acclimation could improve the vitamin K2 yield in Elizabethkingia meningoseptica, but the mechanism remains elusive. Thus, this study is the first which performs genome sequencing of Elizabethkingia meningoseptica sp. F2 as a basis for subsequent experiments and further comparative analyses with other strains. Comparative metabolic pathway analysis of E. meningoseptica sp. F2, E. coli, Bacillus subtilis, and other vitamin K2 product strains revealed that the mevalonate pathway of Elizabethkingia meningoseptica sp. F2 is different in bacteria at the system level. Furthermore, a Quantitative real-time RT-PCR was conducted to determine vitamin K2 biosynthetic gene expression in different developmental phases and strains of Elizabethkingia meningoseptica. The results demonstrated that MenA, MenD, MenH, and MenI of the menaquinone pathway and IDI, HMGR, and GGPPS of the mevalonate pathway had a higher expression compared to the original strain. In addition, isobaric tags for relative and absolute quantitation techniques have been applied in proteomic studies. A total of 67 differentially expressed proteins were identified. These proteins are mainly involved in the oxidative phosphorylation metabolism pathway and the citrate cycle (TCA cycle). Therefore, our results reveal that combined gradient radiation breeding and culture acclimation can promote vitamin K2 accumulation by regulating the vitamin K2 pathway, oxidative phosphorylation metabolism pathway, and the citrate cycle (TCA cycle).
Analysis of Drug Repositioning and Prediction Techniques: A Concise
Review
Authors: He Shida , Liu Xin , Ye Xiucai , Tetsuya Sakurai 
Published: March 2022

Abstract:
High costs and risks are common issues in traditional drug research and development. Usually, it takes a long time to research and develop a drug, the effects of which are limited to rela-tively few targets. At present, studies are aiming to identify unknown new uses for existing drugs. Drug repositioning enables drugs to be quickly launched into clinical practice at a low cost because they have undergone clinical safety testing during the development process, which can greatly re-duce costs and the risks of failed development. In addition to existing drugs with known indications, drugs that were shelved because of clinical trial failure can also be options for repositioning. In fact, many widely used drugs are identified via drug repositioning at present. This article reviews some popular research areas in the field of drug repositioning and briefly introduces the advantages and disadvantages of these methods, aiming to provide useful insights into future development in this field.
Main Fabrication Methods of Micellar Nanoparticles for Nanoscale Tumor
Therapy through the Self-assembly of Amphiphilic Copolymers
Authors: Jia Fan , Su Shishuai , Zhang Ruirui , Wu Yan 
Published: March 2022

Abstract:
Micellar nanoparticles synthesized through the self-assembly of amphiphilic copolymers
have been widely used to encapsulate various cancer therapeutic agents for preclinical and clinical
applications. These drug delivery systems are easy to fabricate and have good biocompatibility in
general. In this article, we provide an overview of the advantages and disadvantages of micellar nanoparticles
for the fabrication of therapeutic agent-loaded nanoparticles from amphiphilic copolymers,
the examples of common polymer materials, and methods used to prepare micellar nanoparticles,
including emulsion solvent evaporation method, double emulsion method, nanoprecipitation
method, etc. By choosing an appropriate technique, different therapeutic agents with different properties
can be incorporated into nanoparticles individually or in combination. We analyzed the parameters
of various preparation methods, with particular emphasis on improvements in improved
techniques for simultaneous co-loading of hydrophilic/hydrophobic drugs and therapeutic nucleic
acids in a single nanoparticle. It will allow researchers to choose the appropriate method to design
therapeutic agent-loaded micellar nanoparticles from amphiphilic copolymers.
Methylated Barbituric Acid-Functionalized Tetraphenylethylene: Aggregation-
Induced Emission, Mechanochromism, and Optical Wave-Guiding
Properties
Authors: Ge Sheng , Xu Xiangjun , Xu Ziqiang , Wang Erjing , Li Dongqin , Wang Shimin 
Published: March 2022

Background:
Restrained by the aggregation-causing quenching of conventional fluorophores,
the design and synthesis of solid-state emissive materials is a persistent pursuit for scientists.
The discovery of aggregation-induced emission provides an efficient strategy for preparing solidstate
emissive luminogens.

Objectives:
A multifunctional solid-state emissive material DMBTPE was prepared from tetraphenylethylene
and N-methylated barbituric acid through the construction of donor-acceptor structure.

Method:
DMBTPE showed typical aggregation–induced emission characteristics: non–emissive
when molecularly dissolved in solution while strongly emissive in the aggregated state or as solid.
Owing to the strong donor–acceptor interaction, the maximum absorption of DMBTPE shifted to
the visible light region. DMBTPE also exhibited reversible mechanochromic fluorescence with 30–
40 nm emission wavelength change.

Results:
DSC and XRD results indicated the transition between the amorphous state and crystalline
state was accounted for the mechanochromic fluorescence behavior. The microcrystalline rods of
DMBTPE grown from hot ethanol solution exhibited good optical waveguiding effect and the optical
loss was as low as 0.018 dB/μm.

Conclusions:
DMBTPE was an efficient solid emitter. Such attributes enable this kind of materials to
find wide applications in many areas, such as biological imaging and optoelectronic devices.
Gilles Lepore, Maciej Madracki y Michal Madracki. Sin ruido, los figurantes del desierto
Authors: Hinojosa Del Ángel Derek 
Published: March 2022

A través de relatos de artistas anónimos, la obra Sin ruido, los figurantes del desierto explora la situación social y cultural que se vive en Uarzazat, una pequeña ciudad al sur de Marruecos. El documental fue dirigido y producido en el año 2017 por el colectivo MML, integrado por los cineastas Gilles Lepore, Maciej Madracki y Michal Madracki. En medio del desolado y caluroso desierto, un grupo de artistas logra superar las problemáticas sociales en las que está sumergida su ciudad, y crea un puente cultural con los medios limitados que están a su alcance. Su objetivo es salir de la marginalidad y conocer el mundo del cine occidental.
El hilo narrativo del documental se compone de una serie de entrevistas hechas a varios artistas que viven en Uarzazat. La cámara los encuadra en close-up, los enfoca delante de un fondo negro, y ellos, con sus dotes histriónicos, se encargan de narrar sus incursiones en el polvoso y caluroso mundo del cine. Las escenas de entrevistas se intercalan con imágenes de la ciudad. Las locaciones están montadas en inmensas planicies donde aparece el equipo de grabación, cuyas cámaras austeras captan a los actores caracterizados con vestimentas religiosas o mitológicas para interpretar a Jesús o a un cíclope.
Las entrevistas se adentran en la intimidad de los artistas y muestran sus historias de vida, las ideas que generan para poder crear otra realidad a partir del cine y la forma en que lo hacen cotidianamente. Sus voces salen de la oscura marginalidad y hablan con crudeza de su contexto social, así como de las alegrías y esperanzas que les ha aportado la cinematogra¬fía. Esas voces han estado en el anonimato por años, y el documental les permite mostrar a los que están más allá del desolado desierto lo que les ha entregado el cine y lo que ellos le han entregado para que permanezca vivo en un lugar inimaginable.
Agnès Varda (directora). Rostros y lugares Francia: Ciné Tamaris, Arte France Cinéma y Rouge International, 2017; 90 minutos.
Authors: Márquez Laura Daniela 
Published: March 2022

Rostros y Lugares es un documental dirigido en el año 2017 por Agnès Varda con la participa-ción especial del fotógrafo JR. Ambos viajan por varios pueblos de Francia, como Chérence o Bonnieux, para fotografiar a sus habitantes. A través de un mosaico apetecible de dibujos, fotografías e historias, y abordo de un camión equipado, Agnès Varda y JR muestran la co-tidianidad de la vida con un sentido poético.
Cada rostro y lugar que fotografían esconde una historia que de vez en cuando aparece en el documental. Por ejemplo: una mujer que creció en un pueblo minero y que se niega a abandonarlo, un hombre que trabaja ochocientas hectáreas en el campo en completa soledad, o un obrero hablando de su jubilación y el vacío que siente al dejar la fábrica. “El arte es para sorprender”, dice otro obrero al ver su rostro plasmado en la pared.
La relación entre Agnès Varda y JR representa la cercanía que existe entre la juventud y la vejez cuando hay una amistad de por medio. Ambos entablan conversaciones sobre temas como la muerte, el apego o desapego a los lugares, la ceguera, por mencionar algunos.
Un documental con matices caseros en cada secuencia: las personas se toman selfies frente a los murales fotográficos, los artistas platican mientras toman té en alguna cafetería, los obreros trabajan, el mar se mece y los vagones del tren avanzan. Todo esto para cerrar con un último recorrido y el encuentro sorpresa con un antiguo amigo de Agnès: Jean-Luc Godard.
Víctor Hernández Vaca. La mata de los instrumentos musicales huastecos Texquitote, San Luis Potosí. México: COLMICH, 2017: 236 pp.
Authors: Avilés Velázquez Víctor Manuel 
Published: March 2022

A diario, inmensidad de músicos tocan sus instrumentos, los palpan, los sienten y los hacen parte de sus cuerpos. Sin embargo, ¿cuántos de ellos conocen el origen, el taller o la fábrica de donde provienen? ¿Cuántos saben del procedimiento y de los materiales que son necesa¬rios para construirlos? En México, el estudio de estos procesos ha sido poco atendido por las investigaciones históricas, antropológicas y etnomusicológicas, a pesar de que la práctica de la construcción instrumental es un eslabón indispensable en las diversas culturas musicales. Víctor Hernández Vaca es un investigador especializado en esta materia, y es con su libro, La mata de los instrumentos musicales huastecos, que da un ejemplo sobre el estudio y análisis de la laudería a partir de distintas herramientas teóricas, así como de la metodología del trabajo de campo aplicada al caso específico de la comunidad Texquitote, municipio de Matlapa, San Luis Potosí.
Lo que pudiera pensarse como un puro proceso mecánico, técnico, es en realidad un entramado de saberes y cosmovisiones que tienen como expresión final una gama de ins-trumentos que representan la tradición festiva y ritual de la música huasteca: guitarra hua-panguera, violín, jarana, rabel, arpa, cartonal, entre otros. La laudería de Texquitote tiene detrás de sí una tradición de cuatro siglos, la cual está impresa en los distintos individuos de la comunidad que la perpetúan y hacen de ella un oficio.
Un hombre sueña que otro hombre (un santo o señor de la tierra) le enseña a fabricar una guitarra, un violín, un rabel u otro instrumento de su tradición, y cuando despierta y se dirige a sus herramientas descubre que puede llevar a la práctica lo que aprendió de su maestro. Así adquiere el don, al cual y por el cual deberá agradecer y guardar respeto. Por ello, sabe que para cada instrumento existe una ceremonia específica, y cuando, por ejemplo, debe construir una pieza dedicada a la música divina, activa todo un ritual que de no llevarse a cabo implicaría el fracaso de su empresa.
¿Cuáles son las técnicas que la divinidad enseña a los lauderos? ¿Qué significados exis¬ten detrás de esas técnicas y cuál es la conexión crucial entre los instrumentos y sus hacedores? Estas y otras preguntas son atendidas por Víctor Hernández Vaca en este libro pionero de una disciplina naciente que él mismo ha acuñado como etnolaudería.
The performance of public health sector in Aceh, Indonesia
Authors: Nanda Nur Sofyana  
Published: March 2022

Abstract
This study analyses performance measurement of public health sector in Aceh province, where this province consists of 17 municipalities and 5 cities. The measurement issue in this study is in terms of efficiency by using a non-parametric method that is Data Envelopment Analysis (DEA). There are two findings that can be applied in policy implications. First, this paper explains the performance measurement of public sector in Aceh using output and input variables. Second, another key finding in this study is to obtain information regarding which district called efficient and vice versa.
Bartik Instruments: An Applied Introduction
Authors: Breuer Matthias 
Published: March 2022

ABSTRACT
This article provides an applied introduction to Bartik instruments. The instruments attempt to reduce familiar endogeneity concerns in differential exposure designs (e.g., panel regressions with unit and time fixed effects). They isolate treatment variation due to the differential impact of common shocks on units with distinct pre-determined exposures. As a result, the instruments purge the treatment variation of possibly confounding factors varying across units over time. Given their broad applicability, Bartik instruments promise to provide researchers with a versatile new tool in their empirical toolbox to investigate relevant accounting questions.
JEL Classifications: C51; M40.