bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of a New Service Delivery Model for Management of Knee Osteoarthritis in Primary Care: A Cluster Randomized Controlled Trial
Authors: Hunter David J. , Bowden Jocelyn L. , Hinman Rana S. , Egerton Thorlene , Briggs Andrew M. , Bunker Stephen J. , French Simon D. , Pirotta Marie , Shrestha Rupendra , Schofield Deborah J. , Schuck Karen , Zwar Nicholas A. , Silva S. Sandun M. , Heller Gillian Z. , Bennell Kim L. ,   and the PARTNER Study Team
Published: October 2022

ObjectiveTo evaluate the effectiveness and health costs of a new primary care service delivery model (the Optimising Primary Care Management of Knee Osteoarthritis [PARTNER] model) to improve health outcomes for patients with knee osteoarthritis (OA) compared to usual care.MethodsThis study was a 2‐arm, cluster, superiority, randomized controlled trial with randomization at the general practice level, undertaken in Victoria and New South Wales, Australia. We aimed to recruit 44 practices and 572 patients age ≥45 years with knee pain for >3 months. Professional development opportunities on best practice OA care were provided to intervention group general practitioners (GPs). All recruited patients had an initial GP visit to confirm knee OA diagnosis. Control patients continued usual GP care, and intervention patients were referred to a centralized care support team (CST) for 12‐months. Via telehealth, the CST provided OA education and an agreed OA action plan focused on muscle strengthening, physical activity, and weight management. Primary outcomes were patient self‐reported change in knee pain (Numerical Rating Scale [range 0–10; higher score = worse]) and physical function (Knee Injury and Osteoarthritis Outcome Score activities of daily living subscale [range 0–100; higher score = better] at 12 months. Health care cost outcomes included costs of medical visits and prescription medications over the 12‐month period.ResultsRecruitment targets were not reached. A total of 38 practices and 217 patients were recruited. The intervention improved pain by 0.8 of 10 points (95% confidence interval [95% CI] 0.2, 1.4) and function by 6.5 of 100 points (95% CI 2.3, 10.7), more than usual care at 12 months. Total costs of medical visits and prescriptions were $3,940 (Australian) for the intervention group versus $4,161 for usual care. This difference was not statistically significant.ConclusionThe PARTNER model improved knee pain and function more than usual GP care. The magnitude of improvement is unlikely to be clinically meaningful for pain but is uncertain for function.
Immune Profiling and Multiplexed Label‐Free Detection of 2D MXenes by Mass Cytometry and High‐Dimensional Imaging
Authors: Fusco Laura , Gazzi Arianna , Shuck Christopher E. , Orecchioni Marco , Alberti Dafne , D'Almeida Sènan Mickael , Rinchai Darawan , Ahmed Eiman , Elhanani Ofer , Rauner Martina , Zavan Barbara , Grivel Jean‐Charles , Keren Leeat , Pasqual Giulia , Bedognetti Davide , Ley Klaus , Gogotsi Yury , Delogu Lucia Gemma 
Published: October 2022

AbstractThere is a critical unmet need to detect and image 2D materials within single cells and tissues while surveying a high degree of information from single cells. Here, a versatile multiplexed label‐free single‐cell detection strategy is proposed based on single‐cell mass cytometry by time‐of‐flight (CyTOF) and ion‐beam imaging by time‐of‐flight (MIBI‐TOF). This strategy, “Label‐free sINgle‐cell tracKing of 2D matErials by mass cytometry and MIBI‐TOF Design” (LINKED), enables nanomaterial detection and simultaneous measurement of multiple cell and tissue features. As a proof of concept, a set of 2D materials, transition metal carbides, nitrides, and carbonitrides (MXenes), is selected to ensure mass detection within the cytometry range while avoiding overlap with more than 70 currently available tags, each able to survey multiple biological parameters. First, their detection and quantification in 15 primary human immune cell subpopulations are demonstrated. Together with the detection, mass cytometry is used to capture several biological aspects of MXenes, such as their biocompatibility and cytokine production after their uptake. Through enzymatic labeling, MXenes’ mediation of cell–cell interactions is simultaneously evaluated. In vivo biodistribution experiments using a mixture of MXenes in mice confirm the versatility of the detection strategy and reveal MXene accumulation in the liver, blood, spleen, lungs, and relative immune cell subtypes. Finally, MIBI‐TOF is applied to detect MXenes in different organs revealing their spatial distribution. The label‐free detection of 2D materials by mass cytometry at the single‐cell level, on multiple cell subpopulations and in multiple organs simultaneously, will enable exciting new opportunities in biomedicine.
Atomic‐Resolution Imaging of the Ice Nucleating Silver Iodide Surface: Does this Polar Surface Reconstruct at the Atomic Scale?
Authors: Sabath Franziska , Aleff Christian , Latus Annamaria , Bechstein Ralf , Kühnle Angelika 
Published: October 2022

AbstractSilver iodide (AgI) particles are known for their outstanding ice nucleation ability. The effective ice nucleation has been explained by the structural similarity of the AgI surfaces and the basal plane of ice Ih. However, the relevant AgI surfaces are polar, i.e., thermodynamically instable. This fact implies the existence of a stabilization mechanism. The nature of this stabilization mechanism remains, however, unknown. Additionally, calculations suggest that exclusively the silver‐terminated and not the iodine‐terminated surfaces nucleate ice. So far, no atomically resolved images at any AgI–water interface exist. This is most likely due to the delicate synthesis and the photolytic degradation of AgI. Here, atomic‐resolution images of the AgI–water interface of freshly cleaved crystals are provided. Most importantly, the atomic structure of these surfaces closely resembles the bulk‐truncated geometry, regardless of the termination. In an attempt to reduce ion adsorption, crystals cleaved in ethanol are investigated. Also in this case, a bulk‐truncated geometry is obtained. The measurements thus reveal no indication for a reconstruction of the AgI cleavage planes neither in water nor in ethanol. This study provides atomic‐scale insights into the interfacial structure, which is essential for understanding the excellent ice nucleation ability of AgI.
Biointerfacial Analysis of HEK293 Cells in Contact with Hydrogels based on Poly‐N‐Isopropylacrylamide and Copolymers
Authors: Capella Virginia , Liaudat Ana C. , Broglia Martin F. , Barbero Cesar A. , Bosch Pablo , Rodríguez Nancy , Rivarola Claudia R. 
Published: October 2022

AbstractSeveral researches have demonstrated that synthetic hydrogels can mimic the mechanical and physicochemical properties of native extracellular matrices and act as cell‐scaffold. The biointerface can influence over tissue activities such as adhesion, signaling, cell–cell communications, and proliferation. In this work, the behavior of human embryonic kidney cells (HEK293) in contact with hydrogel surfaces based on poly‐N‐isopropylacrylamide (PNIPAM) and copolymers is studied. Ionic and neutral hydrogel surfaces are synthesized by free radical polymerization and characterized by Fourier‐transform infrared spectroscopy, swelling capacity, and wettability at culture conditions. Viability, proliferation, and bioadhesive capacity are analyzed by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide and Neutral Red assays, [3H]‐thymidine technique, Acridine Orange and Hoechst dye. Noncytotoxic and proliferative effects are observed in all cases. HEK293 cells are mainly adapted and adhered on neutral and low ionic charge surfaces showing typical cell morphology, and normal mitotic rates. While, lower adhesion, abnormal nuclear and cytoplasmic morphologies with mitotic/fragmentation processes are observed after contact with high ionic surfaces. The cellular cycle after cultive on PNIPAM, assessed by flow cytometry, is not affected regarding control surfaces (polystyrene). Therefore, hydrogel surfaces with neutral and low ionic charges can be apt to in vitro tissue development and possible applications of biomedical treatments.
Non‐Stoichiometric NiFeMo Solid Solutions; Tuning the Hydrogen Adsorption Energy via Molybdenum Incorporation
Authors: Rafei Mouna , Wu Xiuyu , Piñeiro Garcia Alexis , Miranda la Hera Vladimir , Wågberg Thomas , Gracia‐Espino Eduardo 
Published: October 2022

AbstractSolution precursor plasma spraying is used to produce catalytic trimetallic coatings containing Ni, Fe and Mo directly onto stainless‐steel mesh, Ni foam and carbon paper. The resulting material is mostly comprised of face centered cubic FeNi3 alloy forming a highly porous coating with nanostructured features. The addition of Mo (up to ≈14 at%) generates no new crystal phases but only an increase in the lattice parameter, indicating the formation of FeNi3Mox solid solutions. The FeNi3Mox solid solutions are used as electrocatalyst for the hydrogen evolution reaction (HER) in alkaline media. The addition of Mo increases the HER activity significantly reaching an optimum performance at ≈9 at% Mo (FeNi3Mo0.40) with an overpotential at −10 mA cm−2 of 112 mV and a Tafel slope of 109 mV dec−1. The enhanced HER activity is attributed to the formation of a FeNi3Mox solid solution with an increased work function that is correlated to smaller hydrogen adsorption energies. Theoretical activity maps reveal that sites near superficial Mo atoms forms catalytic hot spots and are responsible for the observed activity.
Metal‐Gallium Arsenide Based Tribovoltaic Nanogenerators and its Application for High‐Precision Self‐Powered Displacement Sensors
Authors: Wang Meiqi , Yang Jiayi , Liu Shuangshuang , Meng Yan , Qin Yong , Li Xiuhan 
Published: October 2022

AbstractTriboelectric nanogenerators (TENGs) based on metal and semiconductors have attracted great interest due to their direct‐current (DC) output characteristics and better integration with an integrated circuit. In order to increase the DC output performance, a new type of metal‐gallium arsenide tribovoltaic nanogenerator (MG‐TVNG) is developed. The DC output characteristics of gallium arsenide‐based and silicon‐based devices are compared by a conductive atomic force microscope (CAFM), and the output of gallium arsenide‐based devices is dozens of times higher than that of silicon‐based devices, which verifies the influence of physical factors such as carrier mobility and surface state density on the tribovoltaic effect. The current density of 28.3 A m−2 can be obtained when using a single metal probe to slide on p‐type gallium arsenide, outperforming previously reported silicon TVNGs. The effects of operating parameters such as sliding velocity and load pressure on the output of the MG‐TVNG are further characterized. An MG‐TVNG‐based micro/nano grid displacement sensor is also successfully demonstrated and shows good potential in microscale displacement detecting.
Interactive Aqueous Ink from Core‐Shell Liquid Metal and PEDOT:PSS
Authors: Peng Hao , Peng Yan , Lan Jingyun , Zhou Jiancheng , Zhang Jiuyang 
Published: October 2022

AbstractLiquid metals (LMs) and conjugated polymers are both critically important materials in modern technologies including soft robotics, printable circuits, and stretchable electronics. Although broadly applied, the joint use of LMs and conjugated polymers are rarely explored due to the notoriously interfacial challenges of the high surface tension of LMs and the unfavorable rigid backbones of conjugated polymer chains. This work successfully introduced conjugated polymers (poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate, (PEDOT:PSS)) into the system of liquid metals to provide a highly stable, aqueous, and electrically conductive ink (LM‐PEDOT:PSS inks, LMPInks) for flexible electronics. The PSS segments act as a strong ionic bridge to effectively stabilize core‐shell structure of the PEDOT and LMs in the homogenous ink. Different from previous insulated LM‐inks, LMPInk is aqueous and more importantly, electrically conductive without posttreatments due to the intrinsically conductive PEDOT:PSS. Interestingly, with low content of LM particles (<2 wt%), the printed circuits inherit the valuable transparency of PEDOT:PSS (transmission >92% in visible region), which has never been observed in LM‐based organic systems. Furthermore, such LMPInks show distinguished electrical robustness, which can automatically recover their initial electrical conductivity even after severe physical damage. With the above phenomenal advantages, various flexible circuits on different substrates are successfully provided.
Multielement Polychromatic 2D Liquid Crystal Dammann Gratings
Authors: Zhao Zimo , Chen Bohan , Salter Patrick S. , Booth Martin J. , O'Brien Dominic , Elston Steve J. , Morris Stephen M. 
Published: October 2022

AbstractMultielement and multiwavelength switchable Dammann gratings are demonstrated in polymerizable nematic liquid crystal (LC) devices fabricated using two‐photon polymerization direct laser writing. To begin with, a single element 2D Dammann grating, with a diffraction efficiency of around 60%, is fabricated in a thin polymerizable LC layer such that the grating could be activated and deactivated with the application and removal of an external applied voltage. The impact of the fabrication parameters on the resulting intensity distribution in the far‐field diffraction pattern is presented and discussed, along with results for the response times, which are found to be less than that recorded for the regions of the LC device that did not consist of the laser‐written grating. A multielement device is then presented that exhibits two different Dammann gratings that are activated by the application of two different voltage amplitudes. Results for the corresponding far‐field intensity profiles and response times are presented, which demonstrate that high quality laser written switchable Dammann gratings can be fabricated in polymerizable LCs. These switchable elements have potential in programmable beam shaping, microscopy and optical communication devices.
Pd‐Catalyzed One‐Pot Sequential Sonogashira Coupling and Dual Annulations Cascade for the Synthesis of Benzofuro[3,2‐c]‐Triazalo/Pyrrolo‐Quinolines
Authors: Deokar Dipak B. , Laha Soumi , Sridhar B. , Kumar Tiwari Dharmendra , Likhar Pravin R. 
Published: October 2022

AbstractPalladium‐catalyzed coupling reaction followed by dual annulation has been achieved for the synthesis of various triazolo/pyrrolo fused benzofuro‐quinolines from readily available starting materials. The developed protocol proceeds through palladium‐catalyzed Sonogashira coupling, benzannulation followed by C−H activation triggered second annulation reaction cascades in a single pot. In particular, the polycyclic compound formed by this method consists of three different heterocyclic structures: benzofuran, quinoline, and triazole/pyrrole. The method provides simple access to obtain a range of fused benzofurotriazalo/pyrrolo‐quinolines in good to moderate yields.magnified image
Asymmetric Synthesis of Tricycle‐Fused Dispirooxindoles via Organocatalyzed Three‐Component Cascade Reactions of 2‐Pyrones and Trifluoroethylisatin Ketimines
Authors: Xue Jing , Wang Meng , Zhao Qian , Wang You‐Cheng , Yang Qian‐Qian , Han Bo 
Published: October 2022

AbstractAn asymmetric synthesis of a series of tricycle‐fused dispirooxindoles frameworks assembled in different rings was disclosed via multicomponent cascade 1,3‐dipolar cycloadditions of electron‐deficient 2‐pyrones and trifluoroethylisatin ketimines under the catalysis of hydroquinine or (DHQD)2PHAL with 61→99% ee and >19:1 dr. Meanwhile, these potentially biologically important dispirooxindoles fused pyrrolidinyl/tetrahydropyranone/pyrrolidinyl frame‐works bear eight contiguous stereocenters and functionalized pharmacophores which could further transfer to linaer dispirooxindoles and spirooxindoles bearing epoxyethyl moiety with retentive enantioselectivity.magnified image
Construction of Cyclopenta[b]naphthalenol Frameworks by Weinreb Amide‐Directed Umpolung Ring Opening of Methylenecyclopropanes
Authors: Wei Hao‐Zhao , Wei Yin , Shi Min 
Published: October 2022

AbstractA cascade cyclization from Weinreb amide‐tethered methylenecyclopropanes and alkynes has been disclosed in this paper, which extends the umpolung ring opening of methylenecyclopropanes, giving a synthetic approach for the construction of polycyclic cyclopenta[b]naphthalenol framework. In the protocol, four carbon‐carbon bonds and two carbocycles are formed without the use of transition metals, providing a tool for constructing the structure‐related polycyclic compounds.magnified image
Native Oxidation and Complex Magnetic Anisotropy‐Dominated Soft Magnetic CoCrFeNi‐Based High‐Entropy Alloy Thin Films
Authors: Zhang Junyi , Wang Xiao , Li Xiaona , Zheng Yuehong , Liu Renwei , Luan Junhua , Jiao Zengbao , Dong Chuang , Liaw Peter K. 
Published: October 2022

AbstractSoft magnetic high‐entropy alloy thin films (HEATFs) exhibit remarkable freedom of material‐structure design and physical‐property tailoring, as well as, high cut‐off frequencies and outstanding electrical resistivities, making them potential candidates for high‐frequency magnetic devices. In this study, a CoCrFeNi film with excellent soft magnetic properties is developed by forming a novel core–shell structure via native oxidation, with ferromagnetic elements Fe, Co, and Ni as the core and the Cr oxide as the shell layer. The core–shell structure enables a high saturation magnetization, enhances the electrical resistivity, and thus reduces the eddy‐current loss. For further optimizing the soft magnetic properties, O is deliberately introduced into the HEATFs, and the O‐incorporated HEATFs exhibit an electrical resistivity of 237 µΩ·cm, a saturation magnetization of 535 emu cm−3, and a coercivity of 23 A m−1. The factors that determine the ferromagnetism and coercivity of the CoCrFeNi‐based HEATFs are examined in detail by evaluating the microstructures, magnetic domains, chemical valency, and 3D microscopic compositional distributions of the prepared films. These results are anticipated to provide insights into the magnetic behaviors of soft magnetic HEATFs, as well as aid in the construction of a promising material‐design strategy for these unique materials.
Operando Laboratory‐Based Multi‐Edge X‐Ray Absorption Near‐Edge Spectroscopy of Solid Catalysts
Authors: Genz Nina S. , Kallio Antti‐Jussi , Oord Ramon , Krumeich Frank , Pokle Anuj , Prytz Øystein , Olsbye Unni , Meirer Florian , Huotari Simo , Weckhuysen Bert M. 
Published: October 2022

AbstractLaboratory‐based X‐ray absorption spectroscopy (XAS) and especially X‐ray absorption near‐edge structure (XANES) offers new opportunities in catalyst characterization and presents not only an alternative, but also a complementary approach to precious beamtime at synchrotron facilities. We successfully designed a laboratory‐based setup for performing operando, quasi‐simultaneous XANES analysis at multiple K‐edges, more specifically, operando XANES of mono‐, bi‐, and trimetallic CO2 hydrogenation catalysts containing Ni, Fe, and Cu. Detailed operando XANES studies of the multielement solid catalysts revealed metal‐dependent differences in the reducibility and re‐oxidation behavior and their influence on the catalytic performance in CO2 hydrogenation. The applicability of operando laboratory‐based XANES at multiple K‐edges paves the way for advanced multielement catalyst characterization complementing detailed studies at synchrotron facilities.
Visible‐Light‐Mediated Energy Transfer Enables the Synthesis of β‐Lactams via Intramolecular Hydrogen Atom Transfer
Authors: Oddy Meghan J. , Kusza Daniel A. , Epton Ryan G. , Lynam Jason M. , Unsworth William P. , Petersen Wade F. 
Published: October 2022

AbstractThe synthesis of 2‐azetidinones (β‐lactams) from simple acrylamide starting materials by visible‐light‐mediated energy transfer catalysis is reported. The reaction features a C(sp3)−H functionalization via a variation of the Norrish–Yang photocyclization involving a carbon‐to‐carbon 1,5‐hydrogen atom transfer (supported by deuterium labelling and DFT calculations) and can be used for the construction of a diverse range of β‐lactam products.
A Missing Link in Multisubstituted Pyrrolidines: Remote Stereocontrol Forged by Rhodium‐Alkyl Nitrene
Authors: Tang Xinxin , Tak Raj K. , Noda Hidetoshi , Shibasaki Masakatsu 
Published: October 2022

AbstractPyrrolidines are significant N‐heterocycles in medicinal chemistry and are among the top ten ring systems found in drug molecules. While simple derivatives are commercially available, densely decorated derivatives with precise stereochemical arrangements remain difficult to obtain. Methods for synthesizing multisubstituted pyrrolidines with nonadjacent stereocenters are particularly scarce. To bridge this gap, we report the stereoselective synthesis of remotely decorated, trisubstituted β‐prolines via Rh‐catalyzed C−H amination. The transformation proceeds well in the presence of various functionalities with exclusive anti‐selectivity. Carboxylic acids in the products serve as gateways for diverse downstream transformations. Furthermore, the combined experimental and computational study sheds lights on the origin of high diastereoselectivity.
Harnessing the power of botanical gardens: Evaluating the costs and resources needed for exceptional plant conservation
Authors: Philpott Megan , Pence Valerie C. , Bassüner Burgund , Clayton Ashley S. , Coffey Emily E. D. , Downing Jason L. , Edwards Christine E. , Folgado Raquel , Ligon Jason J. , Powell Christy , Ree Joseph Francis , Seglias Alexandra E. , Sugii Nellie , Zale Peter J. , Zeldin Jacob 
Published: October 2022

AbstractPremiseThe effective ex situ conservation of exceptional plants, whether in living collections or cryo‐collections, requires more resources than the conservation of other species. Because of their expertise with rare plants, botanical gardens are well positioned to lead this effort, but a well‐developed strategy requires a clear understanding of the resources needed.MethodsGrant funding was obtained from the Institute of Museum and Library Services to support a three‐year project on cryobanking, and to provide smaller grants to 10 other botanical gardens for one‐year projects on either (1) seed behavior studies or (2) the development of protocols for in vitro propagation or cryopreservation.ResultsNine of the partner gardens worked on 19 species (one was unable to continue due to the COVID‐19 pandemic), while the larger project focused on 14 species. A point system was developed for tasks accomplished, and the average costs per point of the larger and smaller projects were similar. Labor accounted for half the costs. Projects focused on species in the Asteraceae and Orchidaceae had lower costs per point than other species.DiscussionBoth large and small projects can contribute to a strategy for exceptional plant conservation for similar costs. Prioritizing species with lower costs could help advance the field while allowing time for work on more difficult species to develop.