bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication and characterization of nanoemulsions for encapsulation and delivery of vitexin: antioxidant activity, storage stability and in vitro digestibility
Authors: Chomchoey Sornsawan , Klongdee Supakchon , Peanparkdee Methavee , Klinkesorn Utai 
Published: December 2022

AbstractBACKGROUNDNanoemulsions were prepared as an encapsulation and delivery system for vitexin, a poorly water‐soluble antioxidant. This study evaluated how the type and concentration of the dispersed oil phase and vitexin loading impacted droplet characteristics and nanoemulsion stability. The influences of storage temperature on antioxidant activity and in vitro gastrointestinal digestion on nanoemulsion stability were also investigated.RESULTSNanoemulsions prepared at different dispersed oil concentrations showed diverse characteristics and stability. Highest stability against droplet aggregation and phase separation with small oil droplets (< 150 nm) was observed for nanoemulsions prepared using 300 g kg−1 medium‐chain triglyceride oil. These nanoemulsions are able to entrap and deliver vitexin with high encapsulation efficiency (88–90%) with no significant effect on emulsion stability. Vitexin‐loaded nanoemulsions were stable during storage when refrigerated (4 °C) and at room temperature (25 °C) for up to 45 days with no effect on their antioxidant activity. Significantly delayed lipolysis rate and decreased extent of lipid digestion were observed in vitexin‐loaded nanoemulsions.CONCLUSIONSStable vitexin‐loaded nanoemulsions were successfully produced by high‐pressure homogenization using a mixture of Tween 80 and lecithin as emulsifiers. Vitexin‐loaded nanoemulsions stabilized with a mixture of these two emulsifiers were effective in retaining antioxidant activity during storage and protecting vitexin from changes during gastrointestinal digestion. Our results suggested that nanoemulsions were effective vitexin delivery systems for food applications. © 2022 Society of Chemical Industry.
Characterization and classification of selective Indian chickpea cultivars based on physical and hydration properties, using image and multivariate analysis
Authors: Kaur Ravneet , Prasad Kamlesh 
Published: December 2022

AbstractChickpea (Cicer arietinum) is an important leguminous crop, widely consumed for its high protein content, mainly in Asian countries. India is the largest chickpea‐producing country in the world. Chickpea seeds vary in shape and size depending on the cultivars. Physical properties play an important role in designing the equipment for storage and processing. Thus, the present study was carried out with the objective to characterize selected Indian chickpea cultivars based on their physical properties and hydration characteristics. Hydration is an important preprocessing treatment in most processes like germination, cooking, and fermentation, so the water uptake characteristics (water absorption capacity, swelling index, equilibrium moisture content, and weight gain) vary depending on the size and shape of the seeds. The increase in the length of chickpea seeds after hydration was found to be in the range of 18.18% to 32.08% for different cultivars, whereas the percentage increase in width ranged from 25.62% to 45.45%. The maximum increase in sphericity was 7.39%. Weight gain (%) after hydration was observed to be ranging from 98.87 ± 0.64% to 113.53 ± 0.60%. Comparative characteristics of selective chickpea cultivars based on their physical and hydration properties were studied and classify them using multivariate analysis. Principal component analysis and hierarchical cluster analysis (HCA) for multivariate data may be used to classify the chickpea cultivars. First three principal components explained the 90% variation, with PC1 and PC2 explaining the 73.03% variation. Using HCA, all the cultivars were classified into three clusters based on the similarities in their properties. The three‐dimensional (3‐D) image analysis approach was also employed to study the physical characteristics before and after soaking. It can be a helpful technique for process automation as it is less time consuming.
Recent Progress of Supercontinuum Generation in Nanophotonic Waveguides
Authors: Fang Yuxi , Bao Changjing , Li Si‐Ao , Wang Zhi , Geng Wenpu , Wang Yingning , Han Xu , Jiang Jicong , Zhang Weigang , Pan Zhongqi , Li Zhaohui , Yue Yang 
Published: December 2022

AbstractSupercontinuum (SC) has opened up possibilities for numerous applications in optical communications, signal processing, metrology, and spectroscopy. Supercontinuum generation (SCG) in the integrated nonlinear platforms has attracted much interest recently, due to its fundamental advantages in terms of complementary metal oxide semiconductor compatibility, low power consumption, compact size, and cost‐effectiveness. In this paper, the latest progress on various types of nanophotonic waveguides for SCG is reviewed. The material properties of silicon, germanium, silicon–germanium alloy, silicon nitride, silica, chalcogenide, III–V materials, lithium niobate, and other materials, which are used as nonlinear media for SCG are discussed. The wavelength‐dependent nonlinear Kerr index, material, and nonlinear loss of the waveguides are taken into account. This review mainly focuses on the SCG resulting from the cubic χ(3) nonlinearity processes pumped by the femtosecond pulse. The recent representative SCG works based on the integrated optical waveguides are summarized, and further classified according to the dispersion characteristics. Furthermore, different types of spectra broadening mechanisms in details according to the classifications are analyzed. Perspectives on the SC spectral coverage, the realization of various dispersion curves, and the novel materials, which are the key aspects of the SCG in nanophotonic waveguides are provided.
Picosecond Wide‐Angle Dynamic Beam Steering for Object Tracking
Authors: Li Yue , Geng Xinlin , Kong Xianghong , Liu Xingsi , Liu Zhen , Wang Zheng , Liang Difei , Xie Qian , Xie Jianliang , Deng Longjiang , Qiu Cheng‐Wei , Peng Bo 
Published: December 2022

AbstractBeam steering plays a vital role in light detection and ranging (LiDAR). However, the scanning speed is below megahertz (MHz) in current LiDAR systems. Frequency‐gradient metasurface has been reported to achieve gigahertz (GHz) beam steering with 25° scanning angle in two dimensions. However, the fabrication of millions of form‐varying nanoscale meta‐atoms poses challenges in operation efficiency, massive production, and overall cost‐effectiveness when the size goes beyond millimeter scale. Here, a dynamic beam steering comprising periodic grating nanostructures fabricated through nanoimprint lithography with an ultrafast scanning rate up to GHz (≈81 ps) and ultra‐wide three‐dimensional (3D) fields of view up to 53° × 23° is reported, which shows the powerful acquisition of 3D space data. The detection distance of object reaches to ≈230 m. This work demonstrates a wide‐angle and high‐speed beam steering, and paves a robust way to realize cost‐efficient, high‐volume manufacturing, and powerful 3D all‐solid‐state LiDAR for next‐generation intelligent vision and self‐driving technologies.
Bioinspired Meta‐Reflection‐Splitter for Near‐Infrared Laser Stealth with Large Scattering Angle
Authors: Liu Xianghui , Yan Zhiyuan , Wang Hongtao , Zhao Qibin , Zhou Han , Fan Tongxiang 
Published: December 2022

AbstractMetasurface based phase manipulation has shown great capable of controlling anomalous reflection for low observability against laser active detection. However, current meta‐based designs for laser stealth in near‐infrared (NIR) range suffer from small scattering angles and complex fabrication process, and this hinders their mass productivity and flexible application in actual environments. Here, a bioinspired strategy is proposed to design a meta‐reflection‐splitter with a large scattering angle and strongly extinct specular reflection for NIR laser stealth, motivated by the color splitting effect on the green scale of butterfly Diaethria clymena. The biological reflection splitting is demonstrated to originate from the 180° phase difference of reflection created by the unsymmetrical laminae on densely arranged ridges. A simple etching‐free approach is further developed to generate large‐scale meta‐reflector‐splitter by self‐assembly of colloidal particles. This large‐area meta‐reflector‐splitter shows high‐efficient low observability (ultralow specular reflectance <1%) accompanied by a scattering angle of nearly 50° under the 1064 nm laser detection as well as a low mid‐infrared emissivity. This work sheds light on the phase manipulation of biophotonic structures and thus benefits the innovation in advanced optical materials and devices.
ARRIVE AND THRIVE: COMMITTING TO THE WORK OF THE INCLUSIVE LEADER
Authors: Brady Susan MacKenty , Foutty Janet , Wooten Lynn Perry 
Published: December 2022

AbstractThe authors draw on their extensive research around women’s leadership and delineate lessons for leaders regardless of gender or organizational sector. The article builds on the 7 Impactful Practices for Women Navigating Leadership™. In their words, they are: 1, Investing in your best self. 2, Embracing authenticity. 3, Cultivating courage. 4, Fostering resilience. 5, Inspiring a bold vision. 6, Creating a healthy team environment. 7, Committing to the work of the inclusive leader™. “Inclusive leadership,” the authors write, “must start with the inner work on your identity, and understanding who you are as a leader, or what we call “the knowing.” The Work of the Inclusive Leader is a lifelong, learning journey.” The authors explain further that “With the help of esteemed members of its strategic advisory board, and with our insight and direction, our colleague at Simmons University Institute for Inclusive Leadership Elisa van Dam has led the development of a model that provides a road map for this practice. Called the Work of the Inclusive Leader, this model transpires at three levels: becoming aware (for yourself), becoming an ally and upstander (supporting others), and becoming a change agent (advocating for systemic change).”
FOR NEXT GENERATION LEADERS, REFLECTION PLUS RISK EQUALS REWARDS
Authors: Kurland Michael 
Published: December 2022

AbstractThe author details the qualities that the next generation of leaders will thrive as we get deeper into the 21st century. These are separate from technical and industry‐specific capabilities. They are universal, applicable in a variety of sectors, businesses and beyond. Under the headings of Reflection, Risk, and Reward, he delineates the specifics. For instance, under reflection: “In this 24/7 world, it can be challenging to carve out time for yourself, yet it is vital for your personal and professional growth.” Another point… “we need to encourage our teams to do the same – take the time to reflect on their roles to determine if it is aligned with their purpose and core values, something that is of the utmost importance to this generation of workers.” Within the Risk category: “Organizations that are risk‐averse will find themselves stuck in old ways. This type of thinking can cause employees to be less productive and feel less engaged. With no solid plan for the future that involves a bit of risk‐taking, how can they be expected to stay on for the long haul?” And in Reward, a couple of items to potentially celebrate would be, “Meeting sustainability goals before schedule,” and “Making a difference through social impact programs.”
Suppressed Migration and Enhanced Cisplatin Chemosensitivity in Human Cancer Cell Lines by Tuning the Molecular Mobility of Supramolecular Biomaterials
Authors: Hakariya Masahiro , Arisaka Yoshinori , Masuda Hiroki , Yoda Tetsuya , Iwata Takanori , Yui Nobuhiko 
Published: December 2022

AbstractCancer cells recognize physical cues transmitted from the surrounding microenvironment, and accordingly alter the migration and chemosensitivity. Cell adhesive biomaterials with tunable physical properties can contribute to the understanding of cancer cell responses, and development of new cancer therapies. Previously, it was reported that polyrotaxane‐based surfaces with molecular mobility effectively modulate cellular functions via the yes‐associated protein (YAP)‐related signaling pathway. In the present study, the impact of molecular mobility of polyrotaxane surfaces on the migration and chemosensitivity of lung (A549), pancreatic (BxPC‐3), and breast cancer (MDA‐MB‐231) cell lines is investigated, and it is found that the cellular spreading of adherent A549 and BxPC‐3 cells and nuclear YAP translocation are promoted on low‐mobility surfaces, suggesting that cancer cells alter their subcellular YAP localization in response to molecular mobility. Furthermore, low‐mobility surfaces suppress cellular migration more than high‐mobility surfaces. Additionally, low‐mobility surfaces promote the cisplatin chemosensitivity of each cancer cell line to a greater extent than high‐mobility surfaces. These results suggest that the molecular mobility of polyrotaxane surfaces suppresses cellular migration and enhances chemosensitivity via the subcellular translocation of YAP in cancer cells. Biointerfaces based on polyrotaxanes can thus be a new platform for elucidating cancer cell migration and chemoresistance mechanisms.
Synthesis of Multiresponsive Gold@Polymer‐Nanohybrid Materials Using Polymer Precursors Obtained by Photoiniferter RAFT Polymerization
Authors: Lemich Sascha Benedict , Sobania Nils , Meyer Nils‐Felix , Schütz Patrick , Hankiewicz Birgit , Abetz Volker 
Published: December 2022

AbstractCombining gold nanoparticles (GNP) with stimuli‐responsive polymers is a fascinating field for applications as sensor materials or in biomedical applications. The synthesis of multiresponsive Au@Polymer hybrid systems in an in situ approach using tailor‐made poly(2‐(dimethylamino)ethyl methacrylate) (P(DMAEMA)) precursor synthesized via reversible addition–fragmentation chain transfer (RAFT) polymerization is introduced. In particular, because of its multiresponsive behavior, P(DMAEMA) is of great interest and is used as the precursor for the synthesis. For the polymerization of the precursor, an approach is introduced that applies the photoiniferter RAFT (photoRAFT) mechanism applicable for tertiary amine‐bearing methacrylic monomers like DMAEMA. By varying the chain transfer agents (CTA), the influence of different RAFT Z‐groups on the solubility of the Au‐hybrids is studied. Aging effects are observed by transmission electron microscopy (TEM) analyses. A comprehensive dynamic light scattering (DLS) study reveals the thermoresponsive behavior of the Au‐hybrids in an aqueous solution. The influence of free polymer in solution on the suspension stability is observed. The capability of crosslinking using 1,5‐dibromopentane (DBP) and the CO2 sensitivity of the synthesized hybrids expands the area of their potential application.
Results of a Randomized Clinical Trial of Speech After Early Neurostimulation in Parkinson's Disease
Authors: Pinto Serge , Nebel Adelheid , Rau Jörn , Espesser Robert , Maillochon Pauline , Niebuhr Oliver , Krack Paul , Witjas Tatiana , Ghio Alain , Cuartero Marie‐Charlotte , Timmermann Lars , Schnitzler Alfons , Hesekamp Helke , Meier Niklaus , Müllner Julia , Hälbig Thomas D. , Möller Bettina , Paschen Steffen , Paschen Laura , Volkmann Jens , Barbe Michael T. , Fink Gereon R. , Becker Johannes , Reker Paul , Kühn Andrea A. , Schneider Gerd‐Helge , Fraix Valérie , Seigneuret Eric , Kistner Andrea , Rascol Olivier , Brefel‐Courbon Christine , Ory‐Magne Fabienne , Hartmann Christian J. , Wojtecki Lars , Fradet Anne , Maltête David , Damier Philippe , Le Dily Séverine , Sixel‐Döring Friederike , Benecke Petra , Weiss Daniel , Wächter Tobias , Pinsker Marcus O. , Régis Jean , Thobois Stéphane , Polo Gustavo , Houeto Jean‐Luc , Hartmann Andreas , Knudsen Karina , Vidailhet Marie , Schüpbach Michael , Deuschl Günther ,   for the EARLYSTIM Study Group
Published: December 2022

AbstractBackgroundThe EARLYSTIM trial demonstrated for Parkinson's disease patients with early motor complications that deep brain stimulation of the subthalamic nucleus (STN‐DBS) and best medical treatment (BMT) was superior to BMT alone.ObjectiveThis prospective, ancillary study on EARLYSTIM compared changes in blinded speech intelligibility assessment between STN‐DBS and BMT over 2 years, and secondary outcomes included non‐speech oral movements (maximum phonation time [MPT], oral diadochokinesis), physician‐ and patient‐reported assessments.MethodsSTN‐DBS (n = 102) and BMT (n = 99) groups underwent assessmentson/offmedication at baseline and 24 months (in four conditions:on/offmedication, ON/OFF stimulation—for STN‐DBS). Words and sentences were randomly presented to blinded listeners, and speech intelligibility rate was measured. Statistical analyses compared changes between the STN‐DBS and BMT groups from baseline to 24 months.ResultsOver the 2‐year period, changes in speech intelligibility and MPT, as well as patient‐reported outcomes, were not different between groups, eitherofforonmedication or OFF or ON stimulation, but most outcomes showed a nonsignificant trend toward worsening in both groups. Change in oral diadochokinesis was significantly different between STN‐DBS and BMT groups,onmedication and OFF STN‐DBS, with patients in the STN‐DBS group performing slightly worse than patients under BMT only. A signal for clinical worsening with STN‐DBS was found for the individual speech item of the Unified Parkinson's Disease Rating Scale, Part III.ConclusionAt this early stage of the patients' disease, STN‐DBS did not result in a consistent deterioration in blinded speech intelligibility assessment and patient‐reported communication, as observed in studies of advanced Parkinson's Disease. © 2022 The Authors.Movement Disorderspublished by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Rice Bran Lipidome Identifies Novel Phospholipids, Glycolipids, and Oxylipins with Roles in Lipid Metabolism of Hypercholesterolemic Children
Authors: Barros Santos Millena Cristina , Barouh Nathalie , Lullien‐Pellerin Valérie , Micard Valérie , Villeneuve Pierre , Zhou Bingqing , Oger Camille , Vigor Claire , Durand Thierry , Ferreira Mariana Simões Larraz , Bourlieu‐Lacanal Claire , Ryan Elizabeth P. 
Published: December 2022

ScopeThe purpose of the study is to characterize the chemical diversity in rice bran (RB) lipidome and determines whether daily RB consumption for 4 weeks may modulate plasma lipid profiles in children.Methods and resultsUntargeted and targeted lipidomics via ultra‐performance liquid chromatography coupled with high‐resolution tandem mass spectrometry (UPLC‐MS/MS) are applied to identify bioactive RB lipids from a collection of 17 rice varieties. To determine the impact of RB (Calrose‐USA variety) supplementation on plasma lipid profile, a secondary analysis of plasma lipidome is conducted on data recorded in a clinical study (NCT01911390, n = 18 moderately hypercholesterolemic children) before and after 4 weeks of dietary intervention with a control or RB supplemented (15 g day−1) snack. Untargeted lipidomic reveals 118 lipids as the core of lipidome across all varieties among which phospholipids are abundant and oxylipins present. Phytoprostanes and phytofurans are quantified and characterized. Lipidome analysis of the children plasma following RB consumption reveals the presence of polar lipids and oxylipins alongside putative modulations in endocannabinoids associated with RB consumption.ConclusionThe investigation of novel polar lipids, oxylipins, phytoprostanes, and phytofurans in RB extracts provides support for new health‐promoting properties interesting for people at risk for cardiometabolic disease.
d‐Allulose Supplementation Prevents Diet‐Induced Hepatic Lipid Accumulation via miR‐130‐Mediated Regulation in C57BL/6 Mice
Authors: Yamazaki Mirai , Okito Misaki , Harada Akio , Miyake Keisuke , Tamiya Takashi , Nakamura Takehiro 
Published: December 2022

Scoped‐allulose is a low‐calorie rare sugar. It has been reported that d‐allulose supplementation significantly inhibits diet‐induced hepatic fat accumulation. However, the underlying molecular mechanisms remain unclear. This study elucidates the mechanism underlying the suppressive effect of d‐allulose on hepatic fat accumulation in terms of miRNA regulation.Methods and resultsMale C57BL/6 mice are divided into three experimental groups–normal diet and distilled water (CC group), high‐fat diet (HFD) and distilled water (HC group), and HFD and 5% d‐allulose solution (HA group)–and fed the respective diets for 8 weeks. Weight gain is significantly lower in the HA group than that in the HC group, although the caloric intake is the same in both. Histological analysis of liver tissues reveals excessive lipid accumulation in the HC group; this is greatly attenuated in the HA group. Real‐time PCR and western blot analyses demonstrate that, compared to the HC group, the HA group exhibits decreased hepatic PPARγ and CD36 expression. Hepatic miR‐130 expression levels are higher in the HA group than those in the CC and HC groups.ConclusionsThese results indicate that miRNA changes associated with PPARγ may underlie the suppression of hepatic lipid accumulation induced by d‐allulose intake.
Neutralization‐line‐based decoupling for miniaturized MIMO antenna array
Authors: Wu Ting , Wang Jia‐Wei 
Published: December 2022

AbstractIn this paper, a miniaturized multiple‐input, and multiple‐output (MIMO) antenna array is proposed based on quarter‐mode substrate‐integrated waveguide. The decoupling structure of composite neutralization lines (NLs) is used to improve the isolation of the MIMO antenna array. Each NL comprises a simple metal strip attached to each of the two antenna radiators to create an extra coupling path that opposes the primitive antenna coupling to reduce mutual coupling. Eventually, the 2 × 2 MIMO antenna array is fabricated and implemented to verify the design. The measured impedance bandwidth of S11 less than −10 dB ranges from 3.48 to 3.52 GHz, and the peak gain of the element is 4.87 dBi, the mutual coupling levels between the orthogonal and the parallel antenna elements are −19.2, −22.6, and −17.9 dB, respectively, making it a suitable candidate for MIMO systems.
Compact filters based on dual‐mode gap waveguide cavities and 3D printing technology
Authors: Shu Minjie , Wu Wenxuan , Yang Qian , Chen Jianzhong , Guo Cheng , Zhang Anxue 
Published: December 2022

AbstractThe design of compact dual‐mode/band filters based on gap waveguide and 3D printing technology is presented in this paper. The spatial power divider is designed to arrange the external coupling. And the multi‐slot middle plate is devised to manage the coupling between the dual‐mode cavities, introducing the non‐resonating modes to produce additional transmission zeros and improving the selectivity. Moreover, the dual‐mode/band filters structure are built up and optimized for 3D printing technology. Finally, the fabricated filters are measured to verify the design.