bluuebunny/crossref_metadata_2025_split huggingface dataset:
A national surveillance program for evaluating new reagent lots in medical laboratories
Authors: Solsvik Anne Elisabeth , Kristoffersen Ann Helen , Sandberg Sverre , Gidske Gro , Stavelin Anne Vegard , Eikeland Joakim , Amundsen Erik 
Published: January 2022

Abstract

Objectives
Differences between laboratory results attributable to the use of different reagent lots can potentially affect the diagnosis and monitoring of patients. To minimize patient risks, all laboratories should verify that new reagent lots meet agreed analytical performance specifications (APS). We propose a simplified, pragmatic approach for laboratories that involves compilating results into a national surveillance program, and present the first results obtained when applying this approach to troponins, glycated hemoglobin (HbA1c), prostate-specific antigen (PSA) and D-dimer.

Methods
In the surveillance program we have (i) determined APS for selected analytes, (ii) implemented a simplified procedure for lot evaluation with patient samples used in laboratories across Norway and (iii) performed central processing of the results from the participating laboratories.

Results
Over a one-year period, 27 Norwegian laboratories returned results from 28 lot changes for troponin I, 11 for troponin T, and 29 for HbA1c, PSA and D-dimer. The mean difference between two reagent lots was 4.5% for troponin I (for a concentration interval of 20–32 ng/L), 5.1% for troponin T (10.7–17.5 ng/L), 2.2% for HbA1c (40–50 mmol/mol), 3.7% for PSA (3–5 μg/L) and 5.5% for D-dimer (0.4–1.0 mg/L FEU).

Conclusions
A novel procedure for reagent lot evaluation is proposed in which information about multiple lot changes from different medical laboratories can be accumulated nationally. Sharing this information allows simplification of lot evaluations in individual laboratories and provides real-world data about lot-to-lot variations.
Comprehensive review on synthesis, physicochemical properties, and application of activated carbon from the Arecaceae plants for enhanced wastewater treatment
Authors: Hoang Ngoc Bich , Ngo Thi Cam Quyen , Tran Thi Kim Ngan , Lam Van Tan 
Published: January 2022

AbstractArecaceae presents one of the plant families distributed mainly in the equatorial and subequatorial regions. Arecaceae are widely applied in many fields such as food, cosmetics, fuel, and chemical industries. However, a large amount of agricultural waste from the Arecaceae trees has been released into the environment. The objective of this report is to gain more insights into the potentials and applications of activated carbon (AC) from the Arecaceae trees in wastewater treatment, in which, the ability to handle organic pigments, metals, and antibiotics is focused. The physical properties and processability of AC are statistically evaluated. With a uniform structure, large specific surface area, processing ability according to Langmuir and pseudo-second-order models, we showed that ACs from Arecaceae trees are promising materials for water treatment applications. This is the basis for the development and reduction of by-products that affect the environment.
Functional A Posteriori Error Estimates for the Parabolic Obstacle Problem
Authors: Apushkinskaya Darya , Repin Sergey 
Published: January 2022

Abstract
The paper is concerned with functional-type a posteriori
estimates for the initial boundary value problem for a parabolic partial
differential equation with an obstacle. We deduce a guaranteed and
computable bound of the distance between the exact minimizer and any
function from the admissible (energy) class of functions. Applications
to the analysis of modeling errors caused by data implification are discussed. An important case of time incremental approximations is specially studied. Numerical examples presented
in the last section show how the estimates work in practice.
Prodrug-Activating Chain Exchange (PACE) converts targeted prodrug derivatives to functional bi- or multispecific antibodies
Authors: Dickopf Steffen , Buldun Can , Vasic Vedran , Georges Guy , Hage Carina , Mayer Klaus , Forster Matthias , Wessels Uwe , Stubenrauch Kay-Gunnar , Benz Jörg , Ehler Andreas , Lauer Matthias E. , Ringler Philippe , Kobold Sebastian , Endres Stefan , Klein Christian , Brinkmann Ulrich 
Published: January 2022

Abstract
Driven by the potential to broaden the target space of conventional monospecific antibodies, the field of multi-specific antibody derivatives is growing rapidly. The production and screening of these artificial proteins entails a high combinatorial complexity. Antibody-domain exchange was previously shown to be a versatile strategy to produce bispecific antibodies in a robust and efficient manner. Here, we show that the domain exchange reaction to generate hybrid antibodies also functions under physiological conditions. Accordingly, we modified the exchange partners for use in therapeutic applications, in which two inactive prodrugs convert into a product with additional functionalities. We exemplarily show the feasibility for generating active T cell bispecific antibodies from two inactive prodrugs, which per se do not activate T cells alone. The two complementary prodrugs harbor antigen-targeting Fabs and non-functional anti-CD3 Fvs fused to IgG-CH3 domains engineered to drive chain-exchange reactions between them. Importantly, Prodrug-Activating Chain Exchange (PACE) could be an attractive option to conditionally activate therapeutics at the target site. Several examples are provided that demonstrate the efficacy of PACE as a new principle of cancer immunotherapy in vitro and in a human xenograft model.
Promoting the effect of cationic substitution on thermal stability and redox properties of new synthesized Keggin type lacunary polyoxometalates (L-POMs) Ni2.5PMo11
M(H2O)O39 (M = Co, Fe, Cu, Zn)
Authors: El Arrouji Imane , Oulmekki Abdallah , Harrach Ahmed , Taoufik Mostafa , Lefebvre Frédéric , Toyir Jamil 
Published: January 2022

Abstract
New lacunary Keggin type polyoxometalate salts (Ni2.5PMo11
M(H2O)O39/M = Co, Fe, Cu, Zn), were synthesized using the inorganic condensation method. X-ray diffraction and infrared spectroscopy results showed that the Keggin structure of the salts was preserved. The thermal stability was checked by differential scanning calorimetry coupled with thermogravimetric analysis showing that the thermal resistance was significantly improved by the incorporation of the metals into polyoxometalates. Proton and molybdenum substitution respectively by nickel and cobalt, iron, copper and zinc metals induced a positive effect on the crystallographic configuration of the prepared salts allowing them a better thermal resistance (up to 580 °C). Cyclic voltammetry revealed an interesting electrochemical property of synthesized samples, especially for Ni2.5PMo11Zn(H2O)O39 sample in which the presence of zinc greatly boosted the redox behavior.
Thermodynamic calculation of phase equilibria of rare earth metals with boron binary systems
Authors: Wei Qi , Rong Maohua , Li Sha , Su Di , Yao Qingrong , Wang Jiang , Chen Qing , Rao Guanghui , Zhou Huaiying 
Published: January 2022

Abstract
In order to develop novel materials based on rare earth (RE) boride and/or transition metals, phase equilibria and thermodynamic information of the RE–B based alloys are indispensable. On the basis of experimental phase equilibria and thermodynamic properties, thermodynamic assessments of the RE–B (RE = La, Sm, Gd and Tb) binary systems were carried out by the CALPHAD (Calculation of Phase Diagram) method. Self-consistent parameters of the RE–B (RE = La, Sm, Gd and Tb) binary systems were obtained, which can be used to reproduce well the experimental data. Furthermore, in combination with the previous assessments of the RE–B binary systems in the literature, phase equilibria and thermodynamic properties of the RE–B (RE = La, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er, Tm and Lu) binary systems are discussed systematically. The tendency of phase equilibria and thermodynamic information as a function of RE atomic number is demonstrated. In general, the enthalpy of mixing of liquid RE–B alloys and the enthalpy of formation of the RE–B intermetallic compounds become more and more negative with the increase in RE atomic number (except for La, Ce, Pr and Nd), while the phase transition temperatures for the RE–B intermetallic compounds increase gradually.
Semantic analysis and frequency effects of conceptual metaphors of emotions in Latin. From a corpus-based approach to a dictionary of Latin metaphors
Authors: Buccheri Alessandro , De Felice Irene , Fedriani Chiara , Short William M. 
Published: January 2022

AbstractThis article presents the main results of a corpus-based analysis of the metaphorical expression of emotions in Latin and a new resource specifically designed to facilitate such large-scale study of conceptual metaphors, theLexicon Translaticium Latinum. The first part of the paper provides quantitative and qualitative evidence about the types of metaphors used by Roman writers to express four basic emotions: fear, anger, love, and hate. Our research takes a corpus-based and target-oriented approach, analyzing all occurrences of the main lexemes denoting these emotions in Latin texts dating between the third century BCE and the second century CE. The results demonstrate the highly embodied nature of the metaphors used by Latin authors to make sense of (and express linguistically) their experiences of fear, anger, love, and hate. Moreover, the differences in the usage of the metaphorical patterns across the four semantic fields, in terms of type and frequency, correlate with the different physiological reactions provoked by the four emotions we examined. In the second part of the paper, we present theLexicon Translaticium Latinum, an open-access, digital dictionary of Latin metaphors, currently under development. It facilitates large-scale analyses of highly conventionalized metaphoric patterns that organize meanings throughout Latin, at the same time allowing the kinds of relations that subsist between different types of metaphors to be captured and encoded in machine-readable formats.
The complementary distribution betweennēandnōnrevisited: a semantic approach to wish and result clauses
Authors: Demonie Anne-Li 
Published: January 2022

AbstractThis paper revisits the well-established complementary distribution between the sentential negators in Classical Latin,nēandnōn. It will be shown that in wish and result clauses these negators alternate in a seemingly free manner, which would violate the complementary distribution in its strictest sense. However, this paper argues that the negators can be clearly differentiated semantically, and that there is as such no overlap between their functions. Building on Mellet (1992. L’alternancene/nonen latin Classique.L’Information Grammaticale55.28–32), the alternation in wish and result clauses is discussed, and it is demonstrated that the choice of negator depends on the presence of the subjunctive mood and the presence or absence of epistemic certainty:nēis the negator which is incompatible with epistemic certainty, whereasnōnis the negator which is compatible with it.
Staple line reinforcement with nebulized cyanoacrylate glue in laparoscopic sleeve gastrectomy: A propensity score-matched study
Authors: Martines Gennaro , Tomasicchio Giovanni , Picciariello Arcangelo , Dibra Rigers , Trigiante Giuseppe , Lantone Giuliano , Altomare Donato Francesco 
Published: January 2022

Abstract

Background
A dreaded complication of laparoscopic sleeve gastrectomy (LSG) is suture leak. The study aimed to assess the efficacy of the nebulized comonomer Glubran 2® (N-butyl-cyanoacrylate + metacrylosysolfolane) applied to the LSG staple line.

Methods
A propensity-matched comparison analysis was conducted in 125 patients undergoing LSG between 2017 and 2019. Groups included those treated with Glubran® (group 1, n = 70) and those without Glubran® treatment (group 2, n = 55).

Results
There were differences in the mean body mass index (44.4 vs 43 kg/m2; P < 0.05) between the groups. There was a non-significant increase in the operative time for group 1 compared with group 2 (97 ± 8 vs 93.8 ± 10.7 min; P = 0.07), with a greater amount of estimated blood loss (94.5 mL vs 87.8; P < 0.01). There were more severe complications in group 2 over group 1 cases (8 vs 0%; P < 0.05), although postoperative bleeding did not differ between the two groups (1.4 vs 5.4%). There were no postoperative leaks in group 1 patients, but there were two leaks in group 2 cases with an increased length of hospital stay in patients with a leak.

Conclusion
Glubran® LSG support may reduce leak risk without increasing operating time.
The perspectives of broadband metasurfaces and photo-electric tweezer applications
Authors: Lee Geon , Yu Eui-Sang , Ryu Yong-Sang , Seo Minah 
Published: January 2022

Abstract
With strong demands of real-time monitoring of biomolecules or environmental pollutants, overcoming technical hurdles on control and detection of freely diffusive nanoscale objects become a question of issue to solve in a variety of research fields. Most existing optical techniques inevitably require labeling to the target material, which sometimes denature the measuring biomaterials. For highly efficient real-time monitoring without complicated pretreatment or labeling, many successes in development of label-free or non-destructive detection techniques via increased sensitivity were accomplished by the additional structures. Metasurface-based two-dimensional photonic/electric devices have recently represented extraordinary performances in both manipulation and sensing for various small particles and biochemical species, repeatedly overcoming the limit of detection achieved right before. In parallel, various metasurface-based devices were also introduced promoting transportation of targets into optical hotspot sites, overcoming diffusion limits. We noted this point, therefore, reviewed two major research fields such as metasurface-assisted material sensing and transportation technologies that have contributed to present prospective sensing technologies, then showed perspective views on how great synergy can be created when two technologies are cleverly integrated. Recently, a trend of conceptual merging of optical detection and transporting schemes beyond both diffraction limit and diffusion limit leads to a creation of exceptional performance in molecular detections. In this review, the trends of the latest technologies accomplishing this purpose by hybridization of various composite materials and functional metasurfaces will be introduced.
Progress of albumin-polymer conjugates as efficient drug carriers
Authors: Raveendran Radhika , Dan Xu You , Joshi Nidhi , Stenzel Martina H. 
Published: January 2022

Abstract
Albumin is a protein that has garnered wide attention in nanoparticle-based drug delivery of cancer therapeutics due to its natural abundance and unique cancer-targeting ability. The propensity of albumin to naturally accumulate in tumours, further augmented by the incorporation of targeting ligands, has made the field of albumin-polymer conjugate development a much pursued one. Polymerization techniques such as RAFT and ATRP have paved the path to incorporate various polymers in the design of albumin-polymer hybrids, indicating the advancement of the field since the first instance of PEGylated albumin in 1977. The synergistic combination of albumin and polymer endows manifold features to these macromolecular hybrids to evolve as next generation therapeutics. The current review is successive to our previously published review on drug delivery vehicles based on albumin-polymer conjugates and aims to provide an update on the progress of albumin-polymer conjugates. This review also highlights the alternative of exploring albumin-polymer conjugates formed via supramolecular, non-covalent interactions. Albumin-based supramolecular polymer systems provide a versatile platform for functionalization, thereby, holding great potential in enhancing cytotoxicity and controlled delivery of therapeutic agents.
Psychological interventions in preventing chronicity of sub-acute back pain: a systematic review
Authors: Orenius Tage , Silén Esko , Nuortimo Antti , Ristolainen Leena 
Published: January 2022

Abstract

Objectives
There is scarce information on preventive psychological and behavioural methods applicable to sub-acute (4–12 weeks) back pain, a precursor to chronic back pain. We conducted a systematic literature review of the efficacy of psychological interventions in preventing chronicity of sub-acute back pain.

Methods
A systematic literature search in CINAHL, CENTRAL, MEDLINE, PubMed®, PsychINFO, Scopus and Web of Science databases.

Results
From a total of 271 records, only three studies met the eligibility criteria. In two of the reviewed studies, the interventions had an insignificant preventive impact on the chronification of back pain. In one study the CBT intervention proved promising in preventing back pain related disability. None of the studies reported a significant impact on pain intensity at follow-up.

Conclusions
The psychological interventions did not impact pain outcomes. There is a disproportion between novel knowledge on psychological factors involved in the transition to chronic pain and corresponding preventive treatments. Additional studies on psychological interventions on sub-acute back pain prevention are highly warranted due to the enormous burden that back pain creates when it becomes chronic. The research project has the ethical approval of the Research Ethical Committee at Helsinki University Hospital, HUS/2435/2017.
Simultaneous PIV and shadowgraph measurements of thermo-electrohydrodynamic convection in a differentially heated annulus
Authors: Szabo Peter S. B. , Meyer Antoine , Meier Martin , Motuz Vasyl , Sliavin Yaraslau , Egbers Christoph 
Published: January 2022

Abstract
Convection in a silicone oil with a temperature dependant fluid property is investigated experimentally in a differentially heated cylindrical annulus. A convective flow is induced by terrestrial gravity in axial direction and combined with an electrical tension applied between both cylinders to induce thermo-electrohydrodynamic convection. To capture the evolving velocity and temperature fields a novel combination of simultaneous PIV and shadowgraph technique is utilized. Results reveal azimuthal modes with cold and hot jets from inner and outer cylinder that are referred to the electric tension. The lack of information in the shadowgraph pictures were recovered by the PIV technique providing a deeper understanding in the nature of the development of the azimuthal mode number and the surrounding axial flow of natural convection. In addition, the results provide a robust framework in the capability of combining both techniques to investigate complex flow patterns that are non-axisymmetric.
Synthesis and properties of ester functionalized cationic Gemini surfactants with amide groups
Authors: Lu Xiaohao , Xu Hujun , Zhou Yue , Yao Tingyi , Quan Wang , Gao Haiyan 
Published: January 2022

Abstract
In this paper, a novel series of ester-functionalized cationic Gemini surfactants with amide groups (abbreviated as C
m
-(BAE)-C
m
(m = 12, 14, 16)) were synthesized and their surface tension as well as the thermodynamic surface parameters were determined with conductivity and fluorescence measurements, respectively. The structures of these Gemini surfactants were characterized by FT-IR, 1H NMR, and MS. The Krafft points of the three surfactants are below 0 °C, indicating better water solubility. The critical micelle concentration (CMC) of these surfactants decreases with the increase in the length of hydrophobic chain. The micellization process of these surfactants was found to be entropy-driven. The polar functional ester groups in the spacer form hydrogen bonds with water molecules, which increases the solubility of these Gemini surfactants in aqueous systems, facilitates the aggregation of their monomers and improves the stability of their micelles.
Oryza sativa plant extract in 15% hydrochloric acid as a green corrosion inhibitor on the surface of stainless steel 410
Authors: Bhardwaj Nishant , Sharma Pooja , Kumar Vineet 
Published: January 2022

Abstract
Fifteen percent hydrochloric acid (HCl) solutions are used for some cleaning processes in the petroleum industry. The use of such a corrosive medium is mainly responsible for the corrosion of the stainless steel (SS-410) vessels and pipings. In this study, the corrosion inhibiting properties of Oryza sativa plant extract (OSPE) from agricultural residues are investigated on SS-410 steel surfaces in a 15% HCl medium. Gravimetric analysis showed a maximum corrosion inhibition of 91.92% with 4 g/L OSPE in 15% HCl solution. Scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray diffraction studies confirmed the adsorption of OSPE on the SS-410 surface. The adsorption of OSPE on SS-410 followed the Langmuir adsorption isotherm, indicating the formation of a monolayer on the SS-410 surface. The theoretical study confirmed that the anticorrosive effect could be mainly related to the phytochemical 9,12,15-octadecatrienoic acid 2,3-dihydroxypropyl ester. Consequently, the OSPE containing this phytochemical shows an anticorrosive behavior on the SS-410 surface in an acidic 15% HCl solution.
The “ferros” of MAPbI3: ferroelectricity, ferroelasticity and its crystallographic foundations in hybrid halide perovskites
Authors: Breternitz Joachim 
Published: January 2022

Abstract
Hybrid halide perovskites have been identified as an important novel class of photovoltaic absorbers and have proven their great potential with ever record-breaking efficiencies. Some of the more fundamental properties of halide perovskites, however, still are to be properly understood. The ongoing debate as to whether ferroelectricity and/or ferroelasticity play a role in these materials is just one example for this. Herein, I aim to make these phenomena more approachable to the wider research community and elucidate the foundations and consequences of these phenomena.
Cultivar la excepción: monstruosidad discursiva en Nietzsche
Authors: Zengotita Alonso 
Published: January 2022

El tema de la construcción discursiva en Nietzsche se ha trabajado numerosas veces, pero prácticamente de modo exclusivo desde el lugar del lenguaje, articulado a las nociones de verdad, metáfora, memoria, mentira, conciencia –entre otros.
Sin tomar de modo central a la noción de lenguaje, en el presente artículo se buscará trabajar la forma en que la discursividad en Nietzsche se construye articulándola al modo en que la figura del genio es pensada. Dicho de otro modo, así como el genio aparecerá como excepcionalidad monstruosa, se buscará dar cuenta de cómo la discursividad nietzscheana presenta la misma caracterización frente a la epistemología canónica –aquella que Nietzsche busca confrontar. En orden de realizar esto, en primer lugar se desarrollará cómo Nietzsche piensa al genio como excepción, para luego dar cuenta del lugar diferencial que dicha excepción ocupa respecto de la perspectiva biológica canónica con la que confronta –aquella de Darwin. Desde aquí, desplegando la modalidad de construcción discursiva nietzscheana, se buscará fundamentar cómo y desde qué dinámica ese discurso aparece como monstruosidad excepcional respecto a la epistemología predominante de su época.