bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flood tolerance and flood loss predictions for tepary bean across the U.S. Southern Great Plains
Authors: Witt Travis W. , Flynn K. Colton , Villavicencio Cindy , Northup Brian K. 
Published: June 2022

AbstractFlooding can cause billions of dollars in crop losses per year. One method to combat susceptibility to flooding is through the identification and use of crops that withstand short flooding events. Tepary bean (Phaseolus acutifolius A. Gray) is an underused crop native to North America and currently grown in small amounts by the indigenous peoples of the Sonoran Desert of northern Mexico and southwestern United States. The genome of tepary bean is being used to improve heat, drought, and pest tolerances in common bean (Phaseolus vulgaris L.) through morpho‐physiological changes to the shoots and roots. This study evaluated the effect of different flooding periods on biomass production and tissue C and N content of tepary bean compared with soybean [Glycine max (L.) Merr.]. The study also defined areas of Kansas and Oklahoma that may flood during periods of 1–3 d and potential effects on the two legumes. The analysis determined that for any 1 yr, 22% of Kansas cropland would flood during a 24‐h period and 16% would flood during a 72‐h (3‐d) period. For Oklahoma, 30% of cropland would flood during a 24‐h period and 25% would flood during a 72‐h period. Although tepary bean withstands the abiotic stresses of high temperature and low precipitation, there was less evidence of flood tolerance. Overall, tepary bean genotypes survive 24‐h flooding events, whereas 72‐h events are detrimental to all traits evaluated. The highly erratic high intensity summer rainfalls common to the Southern Great Plains may reduce the ability of tepary bean to dependably produce biomass. Future breeding efforts should include developing flood tolerance in tepary bean to expand the region of use for this legume.
Magnetically accelerated thermal energy storage within Fe3O4‐anchored MXene‐based phase change materials
Authors: Gao Yan , Tang Zhaodi , Chen Xiao , Yan Jiamin , Jiang Yu , Xu Jianhang , Tao Zhang , Wang Lei , Liu Zhimeng , Wang Ge 
Published: June 2022

AbstractInherent weak photon‐capturing ability is a long‐standing bottleneck for pristine phase change materials (PCMs) in photothermal conversion application. To conquer this difficulty, herein, magnetic Fe3O4 nanoparticles were in situ anchored between the layers and the surface of two‐dimensional MXene for the infiltration of myristic acid (MA) by an in situ chemical anchoring strategy. Benefiting from the synergistic localized surface plasmon resonance effect of MXene and Fe3O4 nanoparticles, our designed MXene@Fe3O4‐MA composite PCMs harvested an ultrahigh photothermal conversion efficiency of 97.7%. During the photothermal conversion process, MXene can capture photons and convert solar energy into heat energy efficiently, and the in situ anchored Fe3O4 nanoparticles further enhanced the photothermal conversion efficiency. Moreover, the introduction of Fe3O4 nanoparticles improved the thermal energy storage density (144.17 J/g) of MXene‐MA composite PCMs since Fe3O4 nanoparticles provided more heterogeneous nucleation sites for MA. Simultaneously, MXene@Fe3O4‐MA composite PCMs were endowed with excellent paramagnetism, and realized efficient magnetic‐thermal conversion. Additionally, MXene@Fe3O4‐MA composite PCMs exhibited excellent energy conversion stability, thermal stability, and reliability after undergoing multiple thermal cycles. Therefore, high‐performance MXene@Fe3O4‐based energy conversion composite PCMs are promising candidates to accelerate efficient utilization of the practical solar energy and magnetic energy
Changes in renal function in patients with chronic hepatitis C treated with sofosbuvir‐velpatasvir
Authors: Su Pei‐Kai , Chang Te‐Sheng , Tung Shui‐Yi , Wei Kuo‐Liang , Shen Chien‐Heng , Hsieh Yung‐Yu , Chen Wei‐Ming , Chen Yi‐Hsing , Chen Chun‐Hsien , Yen Chih‐Wei , Xu Huang‐Wei , Tung Wei‐Ling , Chang Kao‐Chi 
Published: June 2022

AbstractDirect‐acting antivirals (DAAs) have become an effective first‐line treatment for chronic hepatitis C (CHC), and the fixed‐dose combination of sofosbuvir (SOF) and velpatasvir (VEL) is one of the most important pangenotypic DAA regimen according to present treatment guideline. The association between SOF‐based regimens and renal toxicity remains controversial. A total of 953 patients including 130 with estimated glomerular filtration rate (eGFR) ≤ 60 mL/min/1.73m2 and 823 with eGFR > 60 mL/min/1.73m2 receiving SOF/VEL therapy for 12 weeks were enrolled in this study. The eGFR was assessed at baseline, end of treatment (EOT), and 12 weeks after completion of the therapy (end of follow‐up, EOF). The eGFR in patients with eGFR ≤ 60 mL/min/1.73m2 increased from baseline (47.89 ± 10.25 mL/min/1.73m2) to EOT (51.65 ± 15.92; P < .001) and EOF (51.51 ± 14.46 mL/min/1.73m2; P < .05). The eGFR in patients with eGFR > 60 mL/min/1.73m2 at baseline (91.52 ± 22.06 mL/min/1.73m2) was lower at EOT (90.37 ± 22.3; P < .05), with no difference between EOT and EOF (P = .06). Multivariable analysis showed that a higher serum albumin level was associated with a lower risk of eGFR decrease at EOT, and the patients with baseline eGFR > 60 mL/min/1.73m2 were associated with a higher risk of eGFR decrease at EOF. The rates of sustained virologic response 12 weeks after treatment cessation (SVR12) were 99.2% in per‐protocol analysis, and the most common adverse events were fatigue (4.7%), abdominal discomfort (4.5%), and skin itching (3.7%). In conclusion, renal function improved after the SOF/VEL treatment in patients with CHC and chronic kidney disease. Thus, SOF/VEL was safe, effective, and tolerable in these patients.
Clinical characteristics, prognostic indicators, and survival outcomes in intravascular lymphoma: Mayo Clinic experience (2003–2018)
Authors: Seegobin Karan , Li Zhuo , Alhaj Moustafa Muhamad , Majeed Umair , Wang Jing , Jiang Liuyan , Kuhlman Justin , Menke David , Li Ke , Kharfan‐Dabaja Mohamed A. , Ayala Ernesto , Iqbal Madiha , Nowakowski Grzegorz S. , Habermann Thomas M. , Witzig Thomas E. , Johnston Patrick , Thompson Carrie , Ansell Stephen , Tun Han W. 
Published: June 2022

AbstractIntravascular lymphoma (IVL) is a rare extranodal non‐Hodgkin lymphoma. We performed a retrospective analysis of 55 IVL patients who were treated at our institution 2003–2018. Median age at diagnosis was 68 years, and 64% were males. The most frequent presenting symptoms were skin rash 43% and weight loss 30%. MRI brain on IVL patients with CNS involvement (CNS‐IVL) showed multifocal involvement in 76% (13/17). 89% (17/19) of non‐CNS‐IVL patients with abnormal FDG‐PET had biopsy of an avid lesion resulting in definitive diagnosis. The top diagnostic biopsy site was the bone marrow (45%). 56% had multiorgan involvement. Based on CNS involvement, 36.5% (20/55) had CNS‐IVL and 63.5% (35/55) had non‐CNS‐IVL. CNS‐IVL group consists of clinically isolated CNS involvement (CNS‐only IVL) (22%;12/55) and mixed clinical CNS and peripheral site involvement (M‐IVL) (14.5%; 8/55). Non‐CNS‐IVL group consists of clinically isolated skin involvement (skin‐only IVL) (9%; 5/55) and peripheral IVL with or without skin involvement (P‐IVL); (54.5%; 30/55). Skin involvement was predominantly in the lower extremities. Pathologically, 89% (48/54) were B‐cell IVL. Rituximab + high‐dose methotrexate‐based regimen were used in 75% (12/16) of CNS‐IVL patients and RCHOP in 60% (17/28) of non‐CNS‐IVL patients. Estimated 5‐year progression free survival (PFS) and overall survival (OS) for the entire cohort were 38.6% and 52%, respectively. Skin‐only IVL was associated with excellent survival. Platelet count <150x109/L, age > 60Y, and treatment without Rituximab were poor prognostic factors. Further research is necessary to identify novel therapies.
An integral monitoring concept for data‐driven detection and localization of incipient leakages by fusion of process and environment data
Authors: Kasten Kristian , Zhu Caroline Charlotte , Birk Joachim , Ding Steven X. 
Published: June 2022

AbstractThe risk of leakages in process industry is environmentally critical and potentially hazardous. Many technologies and schemes for process monitoring are theoretically developed and applied in an industrial context. Nevertheless, most approaches still focus on individual monitoring of a process and its environment. The major challenge is the lack of a priori knowledge about the leakage. This paper introduces a new approach combining monitoring of the environment and its embedded process. The application on an industrial use‐case in a real plant environment illustrates the success of this combined monitoring approach as well as a decision support to localize an incipient leakage.
A New AdvancedMRIBiomarker for Remyelinated Lesions in Multiple Sclerosis
Authors: Rahmanzadeh Reza , Galbusera Riccardo , Lu Po‐Jui , Bahn Erik , Weigel Matthias , Barakovic Muhamed , Franz Jonas , Nguyen Thanh D. , Spincemaille Pascal , Schiavi Simona , Daducci Alessandro , La Rosa Francesco , Absinta Martina , Sati Pascal , Bach Cuadra Meritxell , Radue Ernst‐Wilhelm , Leppert David , Kuhle Jens , Kappos Ludwig , Brück Wolfgang , Reich Daniel S. , Stadelmann Christine , Wang Yi , Granziera Cristina 
Published: June 2022

ObjectivesNeuropathological studies have shown that multiple sclerosis (MS) lesions are heterogeneous in terms of myelin/axon damage and repair as well as iron content. However, it remains a challenge to identify specific chronic lesion types, especially remyelinated lesions, in vivo in patients with MS.MethodsWe performed 3 studies: (1) a cross‐sectional study in a prospective cohort of 115 patients with MS and 76 healthy controls, who underwent 3 T magnetic resonance imaging (MRI) for quantitative susceptibility mapping (QSM), myelin water fraction (MWF), and neurite density index (NDI) maps. White matter (WM) lesions in QSM were classified into 5 QSM lesion types (iso‐intense, hypo‐intense, hyperintense, lesions with hypo‐intense rims, and lesions with paramagnetic rim legions [PRLs]); (2) a longitudinal study of 40 patients with MS to study the evolution of lesions over 2 years; (3) a postmortem histopathology‐QSM validation study in 3 brains of patients with MS to assess the accuracy of QSM classification to identify neuropathological lesion types in 63 WM lesions.ResultsAt baseline, hypo‐ and isointense lesions showed higher mean MWF and NDI values compared to other QSM lesion types (p < 0.0001). Further, at 2‐year follow‐up, hypo‐/iso‐intense lesions showed an increase in MWF. Postmortem analyses revealed that QSM highly accurately identifies (1) fully remyelinated areas as hypo‐/iso‐intense (sensitivity = 88.89% and specificity = 100%), (2) chronic inactive lesions as hyperintense (sensitivity = 71.43% and specificity = 92.00%), and (3) chronic active/smoldering lesions as PRLs (sensitivity = 92.86% and specificity = 86.36%).InterpretationThese results provide the first evidence that it is possible to distinguish chronic MS lesions in a clinical setting, hereby supporting with new biomarkers to develop and assess remyelinating treatments. ANN NEUROL 2022;92:486–502
Designing Protein‐Based Probes for Sensing Biological Analytes with Magnetic Resonance Imaging
Authors: Yun Jason , Baldini Michelle , Chowdhury Rochishnu , Mukherjee Arnab 
Published: June 2022

AbstractGenetically encoded sensors provide unique advantages for monitoring biological analytes with molecular and cellular‐level specificity. While sensors derived from fluorescent proteins represent staple tools in biological imaging, these probes are limited to optically accessible preparations owing to physical curbs on light penetration. In contrast to optical methods, magnetic resonance imaging (MRI) may be used to noninvasively look inside intact organisms at any arbitrary depth and over large fields of view. These capabilities have spurred the development of innovative methods to connect MRI readouts with biological targets using protein‐based probes that are in principle genetically encodable. Here, we highlight the state‐of‐the‐art in MRI‐based biomolecular sensors, focusing on their physical mechanisms, quantitative characteristics, and biological applications. We also describe how innovations in reporter gene technology are creating new opportunities to engineer MRI sensors that are sensitive to dilute biological targets.
A new hybrid ligand and its metal complexes from a natural plant (Styrax officinalis) bearing egonol, thiosemicarbazone and oxime units, and their anti‐cancer activities
Authors: Babahan‐Bircan Ilknur , Emirdağ Safiye , Özmen Ali , Abbak Mürüvvet , Ujam Oguejiofo T. , Demirkaya Ilke , Günay M. Emin 
Published: June 2022

A novel hybrid ligand, a vic‐dioxime ligand (ETO), containing thiosemicarbazone and egonol moieties from a natural plant (Styrax officinalis) and its trinuclear [Ni(II), Cu(II), Co(II), and Fe(II)] and mononuclear [Pd(II) and Zn(II)] complexes have been synthesized and characterized. The ligand, complexes, and natural components were characterized by conventional spectroscopic techniques (IR, NMR, and MS) and evaluated against two human cancer cell lines (MCF‐7 and PC‐3) to determine their antiproliferative and apoptotic properties. Apoptotic or necrotic effects were detected in both cancer cell lines using the Hoechst/propidium iodide double‐staining method. Paclitaxel was used as a positive control (1 μM). The results displayed that the compounds obtained in this study were effective in the concentration range of 5–40 μM in prostate and breast cancer cell lines. It can be said that the compounds (egonol, its derivatives, hybrid ligand, and its metal complexes) are mostly more effective in PC‐3 migration lines. Consequently, the cytotoxic efficiencies of [Cu3(ETO)2·4Cl], 5.27 μM for MCF‐7 and 13.44 μM for PC‐3 and [Zn (ETO)·2Cl] 11.73 μM for MCF‐7 and 9.32 μM for PC‐3 were observed to be close to paclitaxel (a drug used as a cancer chemotherapeutic agent). [Cu3(ETO)2·4Cl] were more effective on the MCF‐7 cell line. Besides this result, [Zn (ETO)·2Cl] was more effective on the PC‐3 cell lines and was more effective by triggering apoptosis in the cells.
Mannose‐targeting Concanavalin A−Epirubicin Conjugate for Targeted Intravesical Chemotherapy of Bladder Cancer
Authors: Huo Fan , Zhang Yang , Li Yiran , Bu Huagang , Zhang Yaliang , Li Wei , Guo Yuna , Wang Lan , Jia Ru , Huang Tengfei , Zhang Weiyi , Li Pengchao , Ding Lin , Yan Chao 
Published: June 2022

AbstractIntravesical instillation of chemotherapeutic drugs such as epirubicin (EPI) is routinely used to prevent tumor recurrence and progression after transurethral resection of bladder tumor. However, the lack of tumor selectivity often causes severe damage to normal bladder urothelium leading to intolerable side effects. Here, we analyzed abnormal changes in glycosylation in bladder cancer and identified mannose as the most aberrantly expressed glycan on the surface of bladder cancer cell lines and human bladder tumor tissues. We then constructed a lectin‐drug conjugate by linking concanavalin A (ConA) – a lectin that specifically binds to mannose, with EPI through a pH‐sensitive linker. This ConA−EPI conjugate conferred EPI with mannose‐targeting ability and selectively internalized cancer cells in vitro. This conjugate showed selective cytotoxicity to cancer cells in vitro and better antitumor activity in an orthotopic mouse model of bladder cancer. Our lectin‐drug conjugation strategy makes targeted intravesical chemotherapy of bladder cancer possible.
Membrane Disruptive Action of Cationic Antibacterial Peptide B1CTcu3
Authors: Ajayakumar Neethu , Narayanan Pratibha , Anitha Anju Krishnan , Mahendran Kozhinjampara R. , Kumar Kesavakurup Santhosh 
Published: June 2022

AbstractA twenty‐two‐residue peptide Brevinin1 Clinotarsus curtipus‐3 (B1CTcu3), identified from the skin secretion of frog Clinotarsus curtipes of the Western Ghats, exhibited a broad range of antibacterial activity against Gram‐negative and Gram‐positive bacteria, including the methicillin‐resistant Staphylococcus aureus (MRSA). It showed anti‐biofilm activity even at sub‐minimum inhibitory concentration (sub‐MIC) against Pseudomonas aeruginosa and Staphylococcus aureus. Analysis of the scanning electron microscopic (SEM) images, confocal images, flow cytometric data and the effect of salt concentration on antibacterial potency suggests that the killing action of the peptide is through the membranolytic process. Single channel electric recording confirmed that the peptide elicited pores on the bacterial cell membrane as it induces a heterogeneous channel in the lipid bilayer. It also showed cytotoxicity against MDA‐MB‐231 breast cancer cell with IC50 of 25 μM. B1CTcu3 peptide could serve as the template for next‐generation antibacterial agents, particularly against antibiotic resistant pathogenic bacteria.
Ru‐P Nanoalloy from Elemental Phosphorus as P‐Source: Synthesis, Characterization and Catalytic Evaluation
Authors: Vanni Matteo , Provinciali Giacomo , Calvo Fuencisla Delgado , Carignani Elisa , Dreyfuss Sébastien , Mézailles Nicolas , Mio Antonio Massimiliano , Nicotra Giuseppe , Caporali Stefano , Borsacchi Silvia , Peruzzini Maurizio , Caporali Maria 
Published: June 2022

AbstractBinary ruthenium‐phosphorus nanoparticles (NPs) with different Ru/P ratio were prepared in mild conditions using white phosphorus (P4) as phosphorus source. Accurate study of both their morphology and structure at the atomic level by TEM and HAADF‐STEM, respectively, showed that Ru2P and RuP have a narrow size distribution (ca. 3.3 nm) and are lacking an ordered ruthenium phosphide lattice.31P Solid State NMR highlighted the existence of three different phosphorus species consistently with the lack of a metal phosphide lattice and finally XPS revealed that the true nature of these nanoparticles can be better described as a ruthenium‐phosphorus alloy. As a benchmark test, the selective hydrogenation of nitroarenes to primary aromatic amines was studied and evidenced how the P‐alloying imparts a surface modification resulting in a higher catalytic activity and excellent chemoselectivity of Ru2P in comparison to Ru(0) and RuP.
Chemical engineering at crossroads
Authors: Nandakumar Krishnaswamy , Tyagi Mayank , Xu Ye , Valsaraj Kalliat T. , Joshi Jyeshtharaj B. 
Published: June 2022

AbstractThrough periodic introspection and assessment, the chemical engineering field has developed a mature undergraduate curriculum built on a strong science background in mathematics, physics, and chemistry. This brings a unique set of skills in transport, reaction engineering, and thermodynamics, coupled with suitable process systems engineering and process design courses, to supply well‐trained engineers to a vast array of process manufacturing facilities. These facilities produce basic chemicals, pharmaceuticals, oil and gas, petrochemicals, food and agricultural products, minerals, and materials. While this maturity has served existing industries well, we argue that the chemical engineering field is at crossroads between managing the curriculum of undergraduate and graduate education to supply the needs of established industries while creating innovators for emerging industries. While this is a great opportunity for yet another introspection, we caution that the inadvertent cannibalization of the field must be avoided. We do argue in favour of adding a biology sequence and a computational science sequence to the core at the undergraduate level in a related perspective article.
N‐Substituted Carbazole Derivate Salts as Stable Organic Electrodes for Anion Insertion
Authors: Russo Roberto , Murugesan Rajesh , Jamali Arash , Chotard Jean‐Noël , Toussaint Gwenaelle , Frayret Christine , Stevens Philippe , Becuwe Matthieu 
Published: June 2022

AbstractHerein the design, synthesis and electrochemical characterization of a set of insoluble molecular carbazole derivatives for electrochemical energy storage is proposed. Two strategies, based on the incorporation of an insoluble fragment or dimerization, were carried out to avoid the dissolution of the active material in the organic carbonate‐based liquid electrolyte solvent. The synthesized compounds enable the reversible anion intercalation from electrolyte, around 4.0 V vs. Li, through a p‐type mechanism, and showed an improvement in cycling stability, making them suitable for application as metal‐free positive electrodes for electrochemical energy storage systems. A first investigation to determine the impact of the electrolyte composition on the anion insertion mechanism and complemented with understanding of the redox mechanism was also carried out.
The Safety, Toleration, and Pharmacokinetics of Two Intravenous Voriconazole Formulations in Healthy Chinese Volunteers After Increasing Dose Administrations
Authors: Chen Gang , Wang Zejuan , Liu Xiaona , Zhang Yanan , Li Min , Du Aihua , Zhen Haiqing , Wang Xiaolin , Zhang Dan , Zhang Mengke , Zang Siqi , Zhang Lina , Zhu Huiting , Wang Jin 
Published: June 2022

AbstractSulfobutyl ether‐beta‐cyclodextrin sodium salt contained in the marketed intravenous voriconazole injection as a solubilizer may cause harmful accumulations. This study aimed to evaluate the safety, tolerability, and pharmacokinetics (PKs) of two intravenous voriconazole formulations containing excipients from different manufacturers using increasing dose administrations in healthy Chinese volunteers. A randomized, double‐blind, placebo‐controlled trial was conducted in three cohorts with 42 healthy Chinese volunteers. Each cohort of 14 volunteers was allocated in proportion (8:4:2) to test the formulation, reference voriconazole, or placebo successively by single‐dose then multiple‐dose administrations of 3, 4, and 6 mg/kg. Forty‐one volunteers completed all drug administrations. The pharmacokinetics of test formulations are characterized by high interindividual variability (coefficient of variance of Cmax up to 68.0%, AUC0‐τ up to 70.2%, and nonlinear PKs with a regression coefficient of Cmax = 1.31 and AUC0‐τ = 1.75 in a single dose). In the steady state, RAuc of the test drug versus reference drug of the 3, 4, and 6 mg/kg dose group were 5.2 and 5.3, 5.6 and 6.3, and 5.8 and 5.5, respectively, and Rcmax were 2.5 and 2.7, 2.6 and 3.1, and 2.8 and 2.6, respectively. Eighty‐three adverse events with 37 transient visual disturbances were mild. PKs with high interindividual variability, nonlinear characteristics, and significant dose‐dependent accumulation were comparable between the two formulations. Overall, the safety of the test formulation was acceptable.