bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis and successful management of an extradural compressive hematoma secondary to diphacinone poisoning in a dog
Authors: Solari Francesca P. , Sherman Alec H. , Blong April E. , Cameron Starr , Walton Rebecca A. 
Published: September 2022

AbstractObjectiveTo describe the successful case management of an extradural hematoma secondary to anticoagulant rodenticide toxicity causing spinal compression and paraplegia.Case SummaryA 3‐month‐old, female intact, mixed breed dog was presented for a 12‐hour history of paraplegia. CBC and biochemistry results were unremarkable, and a coagulation panel revealed prolonged prothrombin time with normal activated partial thromboplastin time. Magnetic resonance imaging revealed an extradural compressive lesion within the vertebral canal extending from T6 to T11, most consistent with an extradural hematoma. Further coagulation testing revealed a coagulopathy caused by vitamin K1 deficiency and confirmed exposure to the anticoagulant rodenticide, diphacinone. The dog was medically managed with fresh frozen plasma, aminocaproic acid, and oral vitamin K1 therapy. A right‐sided T6 to T11 hemilaminectomy was later performed for removal of the extradural hematoma and spinal decompression. The dog's neurological status gradually improved postoperatively and, at the time of discharge, was nonambulatory paraparetic with voluntary micturition. Four weeks postoperatively, the dog had normal prothrombin and activated partial thromboplastin times and was nonambulatory paraparetic with strong motor function.New or Unique Information ProvidedThis is the first reported case of a dog with an extradural hematoma secondary to anticoagulant rodenticide causing spinal cord compression and neurological deficits. Surgical management of this case was successful and resulted in improvement of neurological signs. Extradural hematoma should be considered as a potential location of bleeding in rodenticide toxicity as well as a differential diagnosis in patients with neurological deficits.
Comprehensive validation of fasting-based and oral glucose tolerance test–based indices of insulin secretion against gold standard measures
Authors: Prystupa Katsiaryna , Renklint Rebecka , Chninou Youssef , Otten Julia , Fritsche Louise , Hoerber Sebastian , Peter Andreas , Birkenfeld Andreas L , Fritsche Andreas , Heni Martin , Wagner Robert 
Published: September 2022

IntroductionWith pre-diabetes and diabetes increasingly recognized as heterogeneous conditions, assessment of beta-cell function is gaining clinical importance to identify disease subphenotypes. Our study aims to comprehensively validate all types of surrogate indices based on oral glucose tolerance test (OGTT) and fasting measurements in comparison with gold standard methods.Research design and methodsThe hyperglycemic clamp extended with glucagon-like peptide 1 (GLP-1) infusion and intravenous glucose tolerance test (IVGTT), as well as OGTT, was performed in two well-phenotyped cohorts. The gold standard–derived indices were compared with surrogate insulin secretion markers, derived from fasting state and OGTT, using both Pearson’s and Spearman’s correlation coefficients. The insulin-based and C-peptide-based indices were analyzed separately in different groups of glucose tolerance and the entire cohorts.ResultsThe highest correlation coefficients were found for area under curve (AUC) (I0-30)/AUC (G0-30), I30/G30, first-phase Stumvoll and Kadowaki model. These indices have high correlation coefficients with measures obtained from both insulin and C-peptide levels from IVGTT and hyperglycemic clamp. AUC (I0-120)/AUC (G0-120), BIGTT-AIR0-60-120, I30/G30, first-phase Stumvoll and AUC (I0-30)/AUC (G0-30) demonstrated the strongest association with incretin-stimulated insulin response.ConclusionsWe have identified glucose-stimulated and GLP-1-stimulated insulin secretion indices, derived from OGTT and fasting state, that have the strongest correlation with gold standard measures and could be potentially used in future researches and clinical practice.
Incidence rate, risk factors and behaviour changes for alcohol drinking: findings from a community-based cohort study in Southwest China
Authors: Zhu Bingbing , Zhou Jie , Chen Yun , Xu Kelin , Wu Yanli , Wang Yiying , Wang Na , Liu Tao , Fu Chaowei 
Published: September 2022

ObjectiveTo describe changes in alcohol drinking behaviour, estimate the incidence rate of alcohol drinking and explore its risk factors in the Chinese community population.DesignA community population prospective cohort study.SettingA total of 48 townships of 12 counties or districts in Guizhou province, China.ParticipantsWith the multistage proportional stratified cluster sampling method, a total of 7343 adult residents were enrolled into this study and eligible to be analysed.Primary and secondary outcome measuresThe incidence rate and its risk factor (adjusted HR (aHR) and 95% CIs) as well as the prevalence of alcohol drinking.ResultsThere was a little increase trend in the overall prevalence of alcohol drinking among 7343 subjects over an average of 7.22-year follow-up, and the prevalence in women increased by 2.5% statistically (p=0.001). Among 5005 non-drinkers in 7343 subjects at baseline, 1107 incident drinkers were identified, and the incidence rate of alcohol drinking was estimated at 30.63/1000 person-years with significant sex difference (57.46 vs 17.99 per 1000 person-years for men and women, respectively, p<0.001). The incidence rate decreased gradually with age, peaking in men aged 18–29 years old and women aged 30–39 years old at baseline. After the adjustment for covariates, being male (aHR=3.46, 95% CI: 3.02 to 3.96), being non-Han Chinese (aHR=1.65, 95% CI: 1.44 to 1.88), living in urban areas (aHR=3.50, 95% CI: 3.01 to 4.08), being employed (aHR=1.33, 95% CI: 1.16 to 1.52), smoking (aHR=1.17, 95% CI: 1.00 to 1.38) and having no history of chronic diseases (aHR=1.19, 95% CI: 1.04 to 1.35) were independent risk factors for incident drinkers.ConclusionThe number of women increased in the prevalence of alcohol drinking significantly although there was no significant overall change for the cohort population in Southwest China. Also, there was a high risk of developing alcohol drinking among the study population, especially for those non-drinkers who were younger men, non-Han Chinese, living in urban areas, employed, current smokers or without any chronic diseases. Interventions to prevent and manage alcohol consumption should be designed and implemented in Chinese communities as soon as possible.
Curating a knowledge base for individuals with coinfection of HIV and SARS-CoV-2: a study protocol of EHR-based data mining and clinical implementation
Authors: Liang Chen , Weissman Sharon , Olatosi Bankole , Poon Eric G , Yarrington Michael E , Li Xiaoming 
Published: September 2022

IntroductionDespite a higher risk of severe COVID-19 disease in individuals with HIV, the interactions between SARS-CoV-2 and HIV infections remain unclear. To delineate these interactions, multicentre Electronic Health Records (EHR) hold existing promise to provide full-spectrum and longitudinal clinical data, demographics and sociobehavioural data at individual level. Presently, a comprehensive EHR-based cohort for the HIV/SARS-CoV-2 coinfection has not been established; EHR integration and data mining methods tailored for studying the coinfection are urgently needed yet remain underdeveloped.Methods and analysisThe overarching goal of this exploratory/developmental study is to establish an EHR-based cohort for individuals with HIV/SARS-CoV-2 coinfection and perform large-scale EHR-based data mining to examine the interactions between HIV and SARS-CoV-2 infections and systematically identify and validate factors contributing to the severe clinical course of the coinfection. We will use a nationwide EHR database in the USA, namely, National COVID Cohort Collaborative (N3C). Ultimately, collected clinical evidence will be implemented and used to pilot test a clinical decision support prototype to assist providers in screening and referral of at-risk patients in real-world clinics.Ethics and disseminationThe study was approved by the institutional review boards at the University of South Carolina (Pro00121828) as non-human subject study. Study findings will be presented at academic conferences and published in peer-reviewed journals. This study will disseminate urgently needed clinical evidence for guiding clinical practice for individuals with the coinfection at Prisma Health, a healthcare system in collaboration.
Venlafaxine XR treatment for older patients with major depressive disorder: decision trees for when to change treatment
Authors: Kim Helena Kyunghee , Blumberger Daniel M , Karp Jordan F , Lenze Eric , Reynolds Charles F , Mulsant Benoit H 
Published: September 2022

BackgroundPredictors of antidepressant response in older patients with major depressive disorder (MDD) need to be confirmed before they can guide treatment.ObjectiveTo create decision trees for early identification of older patients with MDD who are unlikely to respond to 12 weeks of antidepressant treatment, we analysed data from 454 older participants treated with venlafaxine XR (150–300 mg/day) for up to 12 weeks in the Incomplete Response in Late-Life Depression: Getting to Remission study.MethodsWe selected the earliest decision point when we could detect participants who had not yet responded (defined as >50% symptom improvement) but would do so after 12 weeks of treatment. Using receiver operating characteristic models, we created two decision trees to minimise either false identification of future responders (false positives) or false identification of future non-responders (false negatives). These decision trees integrated baseline characteristics and treatment response at the early decision point as predictors.FindingWe selected week 4 as the optimal early decision point. Both decision trees shared minimal symptom reduction at week 4, longer episode duration and not having responded to an antidepressant previously as predictors of non-response. Test negative predictive values of the leftmost terminal node of the two trees were 77.4% and 76.6%, respectively.ConclusionOur decision trees have the potential to guide treatment in older patients with MDD but they require to be validated in other larger samples.Clinical implicationsOnce confirmed, our findings may be used to guide changes in antidepressant treatment in older patients with poor early response.
Phase 1 study of C-CAR088, a novel humanized anti-BCMA CAR T-cell therapy in relapsed/refractory multiple myeloma
Authors: Qu Xiaoyan , An Gang , Sui Weiwei , Wang Tingyu , Zhang Xian , Yang Junfang , Zhang Yan , Zhang Lu , Zhu Dan , Huang Jiaqi , Zhu Shigui , Yao Xin , Li Jing , Zheng Chengxiao , Zhu Kevin , Wei Yutian , Lv Xiaoteng , Lan Liping , Yao Yihong , Zhou Daobin , Lu Peihua , Qiu Lugui , Li Jianyong 
Published: September 2022

BackgroundAnti-B-cell maturation antigen (BCMA) chimeric antigen receptor T-cell (CAR T) therapy showed remarkable efficacy in patients with relapsed or refractory multiple myeloma (RRMM). This phase 1 dose-escalation and expansion study developed C-CAR088, a novel second-generation humanized anti-BCMA CAR T-cell therapy, and assessed the safety and efficacy of three dosages of C-CAR088 in patients with RRMM.MethodsPatients received lymphodepletion with three doses of cyclophosphamide (300 mg/m2) and three doses of fludarabine (30 mg/m2) on days –5, –4, and –3, followed by an infusion of C-CAR088 on day 0. Doses of 1.0×106, 3.0×106, and 6.0×106 CAR T cells/kg (±20%) were tested in the dose-escalation cohorts and expansion cohorts. The primary endpoint was treatment safety, including the rate of treatment-emergent adverse events after cell infusion. Secondary endpoints were the overall response rate and progression-free survival. The exploratory endpoints were the quantification of C-CAR088 CAR T cells, selection of cytokines and chemokines in blood, and measurement of tumor BCMA expression.ResultsAs of July 2, 2021, 31 patients had been infused with C-CAR088. Any grade cytokine release syndrome (CRS) occurred in 29 patients (93.5%), and grade 3 CRS occurred in 3 patients (9.7%). One patient from the high-dose group (4.5–6.0×106 CAR T cells/kg) developed grade 1 neurotoxicity. No dose-limiting toxicities were observed in any dose group, and all adverse events were reversible after proper management. The overall response, stringent complete response, complete response (CR), and very good partial response rates were 96.4%, 46.4%, 10.7%, and 32.1%, respectively. The CR rate in the medium-dose (3.0×106 CAR T cells/kg) and high-dose (4.5–6.0×106 CAR T cells/kg) groups was 54.5% and 71.4%, respectively. In the CR group, 15 (93.7%) patients achieved minimal residual disease (MRD) negativity (test sensitivity >1/10−5). All seven patients with double-hit or triple-hit multiple myeloma achieved MRD-negative CR.ConclusionsThe present study demonstrated that C-CAR088 had a good safety profile and high antitumor activity in patients with RRMM, constituting a promising treatment option for RRMM.Trial registration numberNCT03815383,NCT03751293,NCT04295018, andNCT04322292.
Grief and bereavement of family and friends around medical assistance in dying: scoping review
Authors: Yan Han , Bytautas Jessica , Isenberg Sarina Roslyn , Kaplan Ari , Hashemi Narges , Kornberg Mona , Hendrickson Tekla 
Published: September 2022

ObjectivesThe increase in the number of jurisdictions legalising medical assistance in dying (MAiD) has contributed to a growth in the number of family and friends who may face unique elements of grief and bereavement. The aim of this study was to review the literature of grief and bereavement of family and friends following MAiD, and to summarise findings for the development of community resources and programming.MethodsWe performed a scoping review with workshop consultation of stakeholders. Six electronic databases and the grey literature were searched for qualitative, quantitative and review articles. Content-analytical techniques and multidisciplinary discussions led to the development of concepts and a conceptual framework.ResultsTwenty-eight articles met the inclusion criteria. We identified five concepts that impact the grief and bereavement of family/friends: relationships between family/friends and the patient as well as healthcare providers; aspects of MAiD grief which can include secrecy and/or anticipatory grief; preparations which may include family/friends and should be centralised and harmonised; end of life as an opportunity for ceremony; and the aftereffects during which mental health outcomes are studied.ConclusionThis multidisciplinary scoping review incorporates stakeholder consultation to find that support is needed to address the complicated and changing emotions of family/friends before, during and after a MAiD death. Furthermore, additional societal normalisation of MAiD is necessary to reduce secrecy and stigma and improve the accessibility of resources for family/friends.
Uncertainty and hope in relation to anxiety and depression in advanced lung cancer
Authors: Cruz-Castellanos Patricia , Gil-Raga Mireia , Jiménez-Fonseca Paula , Ghanem Ismael , Hernández Raquel , Piera-Molons Nuria , Cano Juana M , Gallego-Martinez Alejandro , Garcia-Torralba Esmeralda , Calderon Caterina 
Published: September 2022

ObjectivesIntolerance of uncertainty (IU) has been linked to greater psychological distress, whereas hope appears to act as a protective factor against in patients with cancer. The aim of this study is to analyse the modifying effect of uncertainty in the presence of anxiety and depression in patients with advanced lung cancer.MethodsMulticentre, prospective, observational, cross-sectional study of 145 individuals with advanced lung cancer. Participants completed the following questionnaires: IU Scale, Hert Hope Index, Brief Symptom Inventory.ResultsAmong patients with advanced lung cancer, anxiety and depression were prevalent, 30% and 35%, respectively. Uncertainty and hope with respect to their illness negatively affected their psychological distress. Hope and uncertainty accounted for 22% of the variance in anxiety and 34% of depressive symptoms. The hypothesised modifying effects (uncertainty×hope) was not supported in the depressive and anxious symptom models.ConclusionsOur findings indicate that hope and uncertainty are important considerations in understanding mental health in people diagnosed with advanced lung cancer. Identifying patients who lack the resources needed to manage uncertainty and hope in relation to their disease could inform psychosocial intervention provision to improve quality of life.
Long-term evolution of the neutron rate at the Canfranc Underground Laboratory
Authors: Orrigo S. E. A. , Tain J. L. , Mont-Geli N. , Tarifeño-Saldivia A. , Fraile L. M. , Grieger M. , Agramunt J. , Algora A. , Bemmerer D. , Calviño F. , Cortés G. , De Blas A. , Dillmann I. , Domínguez Bugarín A. , García R. , Nacher E. , Tolosa-Delgado A. 
Published: September 2022

AbstractWe report results on the long-term variation of the neutron counting rate at the Canfranc Underground Laboratory, of importance for several low-background experiments installed there, including rare-event searches. The measurement campaign was performed employing the High Efficiency Neutron Spectrometry Array (HENSA) mounted in Hall A and lasted 412 live days. The present study is the first long-term measurement of the neutron rate with sensitivity over a wide range of neutron energies (from thermal up to 0.1 GeV and beyond) performed in any underground laboratory so far. Data on the environmental variables inside the experimental hall (radon concentration, air temperature, air pressure and humidity) were also acquired during all the measurement campaign. We have investigated for the first time the evolution of the neutron rate for different energies of the neutrons and its correlation with the ambient variables.
The Role of the Government in the Development of the Rechargeable Battery Industry in Korea
Authors: Jeong Eunsun , Mah Jai S. 
Published: September 2022

Abstract
This article discusses the role of the government in the development of the rechargeable battery, particularly the lithium-ion battery, industry in Korea. The Korean government aimed to promote the small-sized rechargeable batteries in the late 1990s and early 2000s. It began to emphasize support of the middle- to large-sized lithium-ion batteries in the early 2010s. The policy measures have comprised enhancing infrastructure such as human capital and establishment of a rechargeable battery testing center, increasing R&D expenditure, and promoting the electric vehicle (EV) industry through tax and financial incentives, public procurement, and increasing the number of EV charging facilities. Korea has become one of the leading lithium-ion battery producers in the world. The three large Korean companies, i.e. LG Chem, Samsung SDI, and SK Innovation, have come to share more than one-third of the global production of lithium-ion batteries in 2020. Korea’s experience provides policy implications to other countries intending to develop technology-intensive industries. It would be needed for the WTO system to modify the provisions in the sense of providing policy space for development of technology-intensive industries of developing countries.
Il potere delle donne e della loro parola nella Sīrat al-Zīr Sālim
Authors: Potenza Daniela 
Published: September 2022

Abstract
Though, on a first approach, the Sīrat al-Zīr Sālim seems dominated by men, a closer reading reveals that women unexpectedly change the course of events. Especially in today’s printed widespread version, all women existing in this famous popular romance have the power (the so-called “power-with”) to deal with a communal situation for the benefit of a collectivity. This can be said even of Suʿād, which is commonly regarded as the villain of the story. Focusing on women’s words, namely the only words that have the power to persuade, this article aims at showing women’s power and their word’s power in the Sīrat al-Zīr Sālim.
The identity of Pseudecheneis sulcata (M’Clelland, 1842),with descriptions of two new species of rheophilic catfish (Teleostei: Sisoridae) from Nepal and China
Authors: NG HEOK HEE 
Published: September 2022

The identity of Pseudecheneis sulcata is clarified in this study, and the species is redescribed. Pseudecheneis sulcata (from the Brahmaputra River drainage) can be distinguished from congeners in having a unique combination of the lack of a prominent bony spur on the anterodorsal surface of the first dorsal-fin pterygiophore, presence of a first dorsal-fin element, bifid neural spines on the complex vertebra, the neural spines of the last 2–3 preanal and first 6–7 postanal vertebrae gradually increasing in height, separate pelvic fins, a less convex snout when viewed laterally, presence of pale spots on the body, 36–39 vertebrae, 12–14 transverse laminae on the thoracic adhesive apparatus, pelvic-fin length 21.2–28.7% SL, pectoral-fin length 121.6–156.3 % HL, length of adipose-fin base 17.8–22.7% SL, length of caudal peduncle 25.0–28.3% SL, depth of caudal peduncle 4.0–5.2% SL, and eye diameter 8.8–10.6% HL. Pseudecheneis eddsi, new species, is described from tributaries of the Ganges River in Nepal. Pseudecheneis eddsi can be distinguished from congeners by a unique combination of the presence of a prominent bony spur on the anterodorsal surface of the first dorsal-fin pterygiophore, presence of a first dorsal-fin element, bifid neural spines on the complex vertebra, the neural spines of the last 2–3 preanal and first 6–7 postanal vertebrae gradually increasing in height, separate pelvic fins, gently rounded snout when viewed dorsally, presence of pale spots on the body, 36–39 vertebrae, pelvic-fin length 18.0–20.9% SL, pectoral-fin length 114.9–156.0% HL, length of adipose-fin base 19.5–24.3% SL, length of caudal peduncle 25.2–27.8% SL, depth of caudal peduncle 3.5–5.3% SL, and eye diameter 9.6–12.8% HL. Pseudecheneis stenura, new species, is also described from the Irrawaddy River drainage in southwestern China. Pseudecheneis stenura can be distinguished from congeners by a unique combination of the presence of a prominent bony spur on the anterodorsal surface of the first dorsal-fin pterygiophore, presence of a first dorsal-fin element, bifid neural spines on the complex vertebra, the neural spines of the last 2–3 preanal and first 6–7 postanal vertebrae gradually increasing in height, separate pelvic fins, presence of pale spots on the body, 38–40 vertebrae, pelvic-fin length 20.4–24.3% SL, pectoral-fin length 160.4–196.9% HL, length of adipose-fin base 18.8–23.7% SL, length of caudal peduncle 30.3–34.5% SL, depth of caudal peduncle 2.9–3.6% SL, and eye diameter 9.2–12.8% HL. A key to the species of Pseudecheneis is provided.