bluuebunny/crossref_metadata_2025_split huggingface dataset:
A statistical downscaling prediction model for winter temperature over Xinjiang based on the CFSv2 and sea ice forcing
Authors: Liu Jing , Chen Lijuan , Liu Ying 
Published: June 2022

AbstractBased on a year‐to‐year increment approach, a statistical downscaling model is developed for winter temperature prediction over Xinjiang of northwest China by using the predicted 200‐hPa westerly wind in winter over the Ural Mountains from the Climate Forecast System version 2 (CFSv2) as well as the observed sea ice over the Barents Sea–Laptev Sea in the preceding September. The statistical downscaling hindcasts on the 1983–2018 winter temperature over Xinjiang show that the statistical downscaling method has significantly improved the prediction capability compared with the original CFSv2. Specifically, the temporal correlation coefficients increase from negative to positive in most of Xinjiang, with the values passing the significance test at 90% confidence level at 81% of the stations. The regional averaged root‐mean‐square error reduces by more than 20%. In addition, the anomaly correlation coefficient increases from 0.08 to 0.26, passing the significance test at 95% confidence level. For two typical cases of the extreme cold winter in 2011 and the extreme warm winter in 2016, the spatial distribution characteristics of temperature anomaly are well reproduced, which are generally consistent with the observations. Overall, the statistical downscaling model based on the year‐to‐year increment strategy is a relatively effective method for predicting the winter temperature in Xinjiang.
An accurate parameter estimation approach to modeling of solar photovoltaic module using hybrid grey wolf optimization
Authors: Janani C. , Chitti Babu B. , Krishnasamy Vijayakumar 
Published: June 2022

AbstractThis paper proposes a hybrid method for an accurate parameter estimation of the solar photovoltaic (PV) module. The proposed method combines the features of analytical as well as the optimization technique to ensure the speed and accuracy in computation. Two‐diode model consist of seven unknown parameters namely the photocurrent (), reverse saturation current of diode and ( and ), series resistance (), shunt resistance (), diode ideality factor for diode and ( and ). First five parameters are analytically determined with the help of area under the curve, while the remaining two are optimally calculated by using the Grey Wolf Optimization technique. The results obtained by simulation are verified with the experimental data of different PV module and the error is calculated. The superiority of the proposed estimation approach is compared with the recent literature and the results are presented. The proposed model is very useful for the solar PV module designers and simulators to realize its physical characteristics.
Functional analysis reveals ionotropic GABA receptor subunit RDL is a target site of ivermectin and fluralaner in the yellow fever mosquito, Aedes aegypti
Authors: Wang Qiuhui , Wang Haocheng , Zhang Yingxin , Chen Jing , Upadhyay Archana , Bhowmick Biswajit , Hang Jiayu , Wu Shaoying , Liao Chenghong , Han Qian 
Published: June 2022

AbstractBACKGROUNDIonotropic γ‐aminobutyric acid (iGABA) receptors are involved in various physiological activities in insects, including sleep, olfactory memory, movement, and resistance to viruses. Ivermectin and fluralaner can disturb the insect nervous system by binding to iGABA receptors, and are therefore an effective means for controlling insect pests. However, the molecular mechanisms underlying the insecticidal effect of both the compounds on Aedes. aegypti remain unexplored.RESULTSIn this study, we investigated the spatiotemporal expression profile of Ae. aegypti RDL (Ae‐RDL), a subunit of iGABA receptor. RDL dsRNA suppressed the expression of Ae‐RDL mRNA in Ae. aegypti larvae and adult by 60% and 50.67%, resepectly. However, the physiology of Ae. aegypti larvae was not significantly affected. The mortality of Ae. aegypti larvae and adult females subjected to Ae‐RDL knockdown significantly decreased after exposure to ivermectin and fluralaner. Additionally, Ae‐RDL was cloned into Xenopus laevis oocytes and characterized using the two‐electrode voltage‐clamp method. The inward current was induced by GABA binding to the functional Ae‐RDL homomeric receptors at a median effective concentration (EC50) of 100.4 ± 59.95 μM (n > 3). The significant inhibitory effect of ivermectin and fluralaner on inward current indicated that both insecticides exerted a significant antagonistic effect on Ae‐RDL. However, ivermectin also showed strong agonistic as well as weak activation effects on Ae‐RDL. These contrasting effects of ivermectin on Ae‐RDL depended on ivermectin concentration.CONCLUSIONOur study revealed that Ae‐RDL subunit is a target of ivermectin and fluralaner, providing new insights into the insecticidal mechanism of both compounds in Ae. aegypti. © 2022 Society of Chemical Industry.
Traditional Vietnamese medicine Kovir capsule in patients with mild COVID‐19: A double‐blind randomized controlled trial
Authors: Loc Huynh Nguyen , Lan Truong Thi Ngoc , Huong Dinh Thi Lan , Tuyen Nguyen Thanh , Quang Tran Minh , Dao Ly Minh , Van Pham Hung , Vuong Nguyen Lam 
Published: June 2022

AbstractKovir capsule, a polyherbal medicine developed from Ren Shen Bai Du San formulation, has been used in various diseases including respiratory infections. A randomized, placebo‐controlled, double‐blind study was conducted to evaluate the safety and efficacy of Kovir capsule (TD0069) in the treatment of mild COVID‐19 patients. Patients aged from 18 to 65 years who were PCR‐confirmed with SARS‐CoV‐2 and had the mild disease were recruited and randomized to either Kovir capsule (34 patients) or placebo (32 patients) for up to 14 days or until discharge. Efficacy outcomes were time to viral clearance, daily viral load, time to symptom resolution, daily symptom score based on 16 pre‐defined symptoms, and progression to severe/critical COVID‐19. Safety outcomes were adverse events. Viral load decreased over time similarly in the two groups. Viral clearance time was also similar in both groups (median: 8 days). Kovir group had a more rapid decrease of symptom score and significantly lower time to symptom resolution than placebo (median: 4 vs. 7 days). Two patients in the placebo group developed severe COVID‐19. No patient experienced adverse events. Kovir capsule is safe and can improve symptom resolution in mild COVID‐19 patients. A large‐scale trial is required to confirm these findings.
Aortic Arch Variations and Supra-aortic Arterial Tortuosity in Stroke Patients Undergoing Thrombectomy
Authors: Sidiq Maiwand , Scheidecker Emilia , Potreck Arne , Neuberger Ulf , Weyland Charlotte S. , Mundiyanapurath Sibu , Bendszus Martin , Möhlenbruch Markus A. , Seker Fatih 
Published: June 2022

Abstract
Purpose
Unfavorable vascular anatomy can impede thrombectomy in patients with acute ischemic stroke. The aim of this study was to determine the prevalence of aortic arch types, aortic arch branching patterns and supra-aortic arterial tortuosity in stroke patients with large vessel occlusion.

Methods
Computed tomography (CT) and magnetic resonance (MR) images of all stroke patients in an institutional thrombectomy registry were retrospectively reviewed. Aortic arch types and branching patterns of all patients were determined. In patients with anterior circulation stroke, the prevalence of tortuosity (elongation, kinking or coiling) of the supra-aortic arteries of the affected side was additionally assessed.

Results
A total of 1705 aortic arches were evaluated. Frequency of aortic arch types I, II and III were 777 (45.6%), 585 (34.3%) and 340 (19.9%), respectively. In 1232 cases (72.3%), there was a normal branching pattern of the aortic arch. The brachiocephalic trunk and the left common carotid artery had a common origin in 258 cases (15.1%). In 209 cases (12.3%), the left common carotid artery arose from the brachiocephalic trunk. Of 1598 analyzed brachiocephalic trunks and/or common carotid arteries, 844 (52.8%) had no vessel tortuosity, 592 (37.0%) had elongation, 155 (9.7%) had kinking, and 7 (0.4%) had coiling. Of 1311 analyzed internal carotid arteries, 471 (35.9%) had no vessel tortuosity, 589 (44.9%) had elongation, 150 (11.4%) had kinking, and 101 (7.7%) had coiling.

Conclusion
With 20%, type III aortic arches are found in a relevant proportion of stroke patients eligible for mechanical thrombectomy. Nearly half of the stroke patients present with supra-aortic arterial tortuosity, mostly arterial elongation.
Riemann surfaces of second kind and effective finiteness theorems
Authors: Jöricke Burglind 
Published: June 2022

AbstractThe Geometric Shafarevich Conjecture and the Theorem of de Franchis state the finiteness of the number of certain holomorphic objects on closed or punctured Riemann surfaces. The analog of these kind of theorems for Riemann surfaces of second kind is an estimate of the number of irreducible holomorphic objects up to homotopy (or isotopy, respectively). This analog can be interpreted as a quantitatve statement on the limitation for Gromov’s Oka principle. For any finite open Riemann surface X (maybe, of second kind) we give an effective upper bound for the number of irreducible holomorphic mappings up to homotopy from X to the twice punctured complex plane, and an effective upper bound for the number of irreducible holomorphic torus bundles up to isotopy on such a Riemann surface. The bound depends on a conformal invariant of the Riemann surface. If $$X_{\sigma }$$

X
σ

is the $$\sigma $$
σ
-neighbourhood of a skeleton of an open Riemann surface with finitely generated fundamental group, then the number of irreducible holomorphic mappings up to homotopy from $$X_{\sigma }$$

X
σ

to the twice punctured complex plane grows exponentially in $$\frac{1}{\sigma }$$

1
σ

.
High-Intensity Exercise and Geometric Indices of Hip Bone Strength in Postmenopausal Women on or off Bone Medication: The MEDEX-OP Randomised Controlled Trial
Authors: Kistler-Fischbacher Melanie , Yong Jedidah S. , Weeks Benjamin K. , Beck Belinda R. 
Published: June 2022

AbstractTo compare the effects of high-intensity resistance and impact training (HiRIT) to low-intensity, Pilates-based exercise (LiPBE) on proximal femur geometry and explore the influence of antiresorptive medication on those effects. Postmenopausal women with low bone mass, on or off antiresorptive bone medications were randomly allocated, stratified on medication intake, to eight months of twice-weekly, supervised HiRIT (Onero™) or LiPBE (Buff Bones®). 3D hip software was used to analyse proximal femur DXA scans. Outcomes included femoral neck (FN) and total hip (TH), volumetric (e.g. vBMC, vBMD) and geometric (e.g. cortical thickness, cross-sectional area [CSA], section modulus [Z]) indices of bone strength. Data were analysed using analysis of variance. Scans of 102 women were examined: LiPBE, 43; HiRIT, 37; LiPBE-med, 11; HiRIT-med, 11. HiRIT improved TH trabecular vBMC and vBMD (3.1 ± 1.1% versus − 1.2 ± 1.2%, p = 0.008; and 1.5 ± 1.0% versus − 1.6 ± 1.2%, p = 0.042, respectively) and FN and TH total vBMC (2.0 ± 0.8% versus − 0.2 ± 0.7%, p = 0.032; and 0.7 ± 0.4% versus − 0.8 ± 0.6%, p = 0.032, respectively), compared to losses in LiPBE. HiRIT also increased Z while LiPBE did not (p = 0.035). The combination of HiRIT and medication achieved greater improvements in FN total and trabecular vBMD, total BMC, CSA and Z than HiRIT alone. HiRIT improved geometric parameters of proximal femur strength, while LiPBE exercise was largely ineffective. Medication may enhance some HiRIT effects. Findings suggest reduced hip fracture risk in response to HiRIT.Trial registration number ACTRN12617001511325.
Repeat Resection for Advanced Colorectal Liver Metastases—Does it have the Potential for Cure?
Authors: Takeda Yoshinori , Mise Yoshihiro , Ito Hiromichi , Ono Yoshihiro , Sato Takafumi , Inoue Yosuke , Takahashi Yu , Saiura Akio 
Published: June 2022

AbstractBackgroundAlthough surgical resection is the only potential treatment for patients with colorectal liver metastases (CLM), the actual cure is rare in patients with advanced CLM. Repeat resection (RR) is the most effective treatment in patients with recurrence; however, whether patients with initially advanced CLM achieve cure throughout RR or experience repeated recurrence even after RR remains unclear. In this study, we analyzed whether patients with advanced CLM achieve cure after RR.MethodsConsecutive patients who underwent initial hepatectomy with curative intent for CLM from January 1999 to August 2007 were included. Patients who were alive at 10 years from the initial hepatectomy without any evidence of recurrence were defined as cured. Cure rates were compared between patients with Fong's clinical risk score (CRS) of ≥ 3 and those with CRS of ≤ 2.ResultsA total of 257 patients were included and followed up. Among them, 93 (36.2%) patients achieved actual cure postoperatively. The cure rate of patients with a CRS of ≥ 3 was 32.4% (33/102), which was not different from that of patients with a CRS of ≤ 2 (38.7% [60/155]; p = 0.299), although former patients had higher recurrence rate after the initial hepatectomy than latter ones (85.3% vs. 72.3%; p = 0.014). The cure rates after the initial, second, and third resections were 23.0% (59/257), 30.0% (24/80), and 22.5% (7/31), respectively. In multivariate analysis, RR was determined as an independent favorable factor of achieving cure.ConclusionsRR had a potential to cure patients with advanced CLM, and one‐third of them achieved cure.
Gap balanced adjusted mechanical alignment versus measured resection mechanical alignment: a randomised controlled trial
Authors: Waterson Hugh , Walker Robert , Koopmans Petra , Stroud Rowenna , Phillips Jonathan , Mandalia Vipul , Eyres Keith , Toms Andrew 
Published: June 2022

Abstract
Introduction
Alignment goals in total knee replacement (TKR) is a topical subject. This study compares the short-term functional outcomes and patient reported outcome measures (PROMs) of two philosophies for knee arthroplasty alignment: measured resection (MR) and an individualised alignment philosophy, with the tibia mechanically aligned and an instrumented gap balancer (GB) to align the femur in both flexion and extension.

Patients and methods
94 knees were enrolled in this randomised controlled trial. The surgical protocol used a MR technique for mechanical alignment or a GB technique for individualised alignment. Primary outcome was quadriceps strength. Secondary outcomes included validated functional tests and PROMs as well as patient satisfaction. Outcomes were assessed pre-operatively, at 6 weeks, 3, 6 and 12 months post-operatively.

Results
At 12-month follow-up, there was no significant difference in the change from baseline mean quadriceps peak torque between the two groups (p = 0.988). Significant improvement in the change in range of motion (ROM) in the GB group compared to the MR group at 3 months (13° vs 6° p = 0.028) but this improvement was not significant at 1 year (20° vs 17° p = 0.21). The functional test of balance showed statistically significant improvement at 6 weeks (p = 0.03) in the GB group but this difference was not maintained. PROMs favoured the GB group, with the KOOS pain scoring statistically better (p ≤ 0.05) at 6 weeks, 3, 6 and 12 months.

Conclusions
Individualised alignment philosophy utilising a GB technique did not demonstrate an improvement in the primary outcome measure quadriceps peak torque. Improvement was seen in the GB group in PROM pain scores that was significant, both statistically and clinically, out to at least 1 year. Gains that were seen in functional assessment with GB, although significant at some time points, were no longer significant at 1 year and no difference was seen in quads strength. Compared to a MR technique, the individualised GB technique appears to confer some improvement in pain, ROM and some functional tests following TKR in the short-term.
Task-irrelevant auditory metre shapes visuomotor sequential learning
Authors: MacIntyre Alexis Deighton , Lo Hong Ying Josephine , Cross Ian , Scott Sophie 
Published: June 2022

AbstractThe ability to learn and reproduce sequences is fundamental to every-day life, and deficits in sequential learning are associated with developmental disorders such as specific language impairment. Individual differences in sequential learning are usually investigated using the serial reaction time task (SRTT), wherein a participant responds to a series of regularly timed, seemingly random visual cues that in fact follow a repeating deterministic structure. Although manipulating inter-cue interval timing has been shown to adversely affect sequential learning, the role of metre (the patterning of salience across time) remains unexplored within the regularly timed, visual SRTT. The current experiment consists of an SRTT adapted to include task-irrelevant auditory rhythms conferring a sense of metre. We predicted that (1) participants’ (n = 41) reaction times would reflect the auditory metric structure; (2) that disrupting the correspondence between the learned visual sequence and auditory metre would impede performance; and (3) that individual differences in sensitivity to rhythm would predict the magnitude of these effects. Altering the relationship via a phase shift between the trained visual sequence and auditory metre slowed reaction times. Sensitivity to rhythm was predictive of reaction times over all. In an exploratory analysis, we, moreover, found that approximately half of participants made systematically different responses to visual cues on the basis of the cues’ position within the auditory metre. We demonstrate the influence of auditory temporal structures on visuomotor sequential learning in a widely used task where metre and timing are rarely considered. The current results indicate sensitivity to metre as a possible latent factor underpinning individual differences in SRTT performance.
Heat traveling waves in rigid thermal conductors with phase lag and stability analysis
Authors: Abdel-Gawad H. I. , Abou-Dina M. S. , Ghaleb A. F. , Tantawy M. 
Published: June 2022

AbstractRecently, a model equation that describes nonlinear heat waves in a rigid thermal conductor has been derived. The system of the governing equations for temperature and heat flux is nonlinear. The objective of the present work is to find a variety of traveling wave solutions of this system of equations in the whole space. This is achieved by implementing the unified method. The obtained solutions are evaluated numerically and represented graphically. The behavior of these solutions is investigated, where it is shown that the temperature and the heat flux attain steady states in space, but increase with time. The effects of the characteristic length, time, heat flux, and reference temperature are studied via some material data. It is shown that the solutions may have the form of solitary wave, soliton, or soliton with double kinks. It is observed that the heat flux in the material is negative, this reflects the fact that heat flux is in the opposite direction of the normal vector to the material surface on which it is evaluated. The steady state solution of the considered model equation is studied. It is found that the stability of the solutions depends significantly on the wave number.
Response of reinforced mortar-less interlocking brick wall under seismic loading
Authors: Xie Guanyu , Zhang Xihong , Hao Hong , Bi Kaiming , Lin Yuanzheng 
Published: June 2022

AbstractMortar-less construction with interlocking bricks has many advantages, such as improved construction efficiency and relatively low requirements on labour skills. Nevertheless, the seismic performance of interlocking brick structures is not well understood yet. In this paper, laboratory tests and numerical modelling are carried out to investigate the seismic behaviour of interlocking brick walls. Laboratory shaking table tests are performed on a scaled reinforced mortar-less interlocking brick wall. The response and damage modes under in-plane seismic loading are investigated. A detailed numerical model is then generated and validated with the laboratory testing data. Unlike the conventional masonry wall that diagonal shear damage governs the failure, the interlocking brick wall exhibits rocking responses, whose damage is mainly at the two bottom corners of the wall. Full-scale interlocking brick walls are then modelled and compared with conventional concrete masonry unit (CMU) walls bonded by mortar. Comparisons are made between the seismic resistances and damage modes of the two walls. The influences of ground motion intensities, vertical components of seismic excitations and different seismic time histories on the seismic behaviour of the interlocking brick wall are examined. It is found that the interlocking brick wall has a higher seismic resistance capacity than the conventional CMU wall. Inter-brick friction is the main energy dissipation mechanism in the interlocking brick wall. Because of the rocking response, vertical component of the ground motion significantly influences the damage of interlocking brick wall. The interlocking brick wall is insensitive to velocity pulses of ground motions due to its relatively high natural frequency.
Sorption of uranium(VI) from aqueous solution using nanomagnetite particles; with and without humic acid coating
Authors: Helal Aly A. , Ahmed I. M. , Gamal R. , Abo-El-Enein S. A. , Helal A. A. 
Published: June 2022

AbstractIn this study, iron oxide nanoparticles (Fe3O4) and iron oxide nanoparticles with humic acid coatings (Fe3O4/HA) were investigated for the removal of U(VI). The effect of contact time, adsorbent mass, U(VI) concentration, and pH was studied by batch technique. The sorption kinetic data follows pseudo-second order, while the isotherms obey Langmuir with Qmax values of 238.0, 195.6 mg/g for Fe3O4 and Fe3O4/HA, respectively. According to the study, humic acid decreases the sorption capacity of magnetite due to the formation of a polyanionic organic coating, altering the surface properties of the particles, reducing magnetite aggregation, and stabilizing magnetite suspension.
Where ridehail drivers go between trips
Authors: Millard-Ball Adam , Liu Liwei , Hansen Whitney , Cooper Drew , Castiglione Joe 
Published: June 2022

AbstractWe analyze what ridehail drivers do when searching for paid fares. We use a dataset of 5.3 million trips in San Francisco and partition each search trip into cruising, repositioning, and parking segments. We find that repositioning accounts for nearly two-thirds (63%) of the time between trips, with cruising and parking accounting for 23% and 14% respectively (these figures exclude short trips). Our regression models suggest that drivers tend to make reasonable choices between repositioning and parking, heading to high-demand locations based on the time of day. However, we also find evidence of racial disparities, supporting previous studies of both taxis and ridehailing that indicate that drivers tend to avoid neighborhoods with high proportions of residents of color.