bluuebunny/crossref_metadata_2025_split huggingface dataset:
UZAKTAN EĞİTİM SÜRECİNDE İÇ MEKAN VE MOBİLYA TARİHİ II VE PERSPEKTİF DERSİ KAPSAMINDA ÖĞRENME ÇIKTILARI VE ÖĞRENCİ MOTİVASYON DEĞERLENDİRMESİ: ESTÜ İÇ MİMARLIK ÖRNEĞİ
Authors: AĞAOĞLU ÇOBANLAR Gül , KAPTAN Buğru Han Burak 
Published: June 2022

Toplum sağlığını etkileyen COVID-19 pandemisi toplumsal yaşamın kısıtlanmasına neden olmuştur.
Yüz yüze başlayan eğitim, alınan önlemler sebebiyle mevcut eğitimin çevrimiçi ortamlarda yürütülmesi
anlamını taşıyan acil uzaktan öğretim modeliyle devam etmiştir. İç mimarlık eğitiminde de internet tabanlı
uzaktan eğitim modeline geçilmiş ve müfredatlarında yer alan kuramsal dersler ile uygulamalı dersler internet
tabanlı yürütülmeye devam etmiştir. Bu süreçte öğrenenlerin yürütülen derslere karşı motivasyonlarının
olması, derslerin öğrenme çıktılarının kazanımları açısından önemlidir. Araştırmada 2019-2020 Bahar
Döneminde yüz yüze eğitimle başlayan ancak küresel salgın nedeniyle Acil Uzaktan Öğretim kapsamında
uzaktan eğitim ilkeleriyle yürütülen dersler ele alınmıştır. Kuramsal olarak İç Mekân ve Mobilya Tarihi II,
uygulamalı olarak Perspektif derslerinin öğrenme çıktıları ve motivasyon düzeyleri üzerinden incelenmesi
amaçlanmıştır. Her iki ders çevrimiçi platformlar yardımıyla yürütülmüştür. Kuramsal ders kapsamında
öğrenenler araştırma yapmaya teşvik edilmiştir. Elde edilen veriler üzerinden tartışma ortamı yaratılmıştır.
Uygulamalı derste ise görerek ve yaparak öğrenme ortamı yaratabilmek amaçlanmıştır. Farklı öğrenme araçları
olarak ders anlatımı, videolar, föyler, uygulama çizimleri paylaşılarak öğrenme süreçleri desteklenmiştir.
Araştırma, nitel ve nicel veri toplama araçları kullanılarak karma yöntem ile desenlenmiştir. Açıklayıcı
(explanatory) desen ile çalışma kapsamında toplanan nicel veriler nitel verilerle desteklenmiştir. Elde edilen
veriler doğrultusunda pandemi sürecinde uygulanan ders işleme yöntemlerinin kuramsal ve uygulamalı
derslerde olumlu sonuç verdiği ortaya çıkmıştır.
ETKİLEŞİM KAVRAMI VE ETKİLEŞİMLİ İNFOGRAFİKTE TASARIM GELİŞTİRME SÜRECİ
Authors: SEZER Ayşegül , KAHRAMAN Mehmet Emin 
Published: June 2022

Etkileşimli medya ortamlarında, kullanıcılar ve nesneler arasında bir etkileşim meydana gelirken bir
iletişim de oluşmaktadır. Bunun sonucunda etkileşim, bir iletişim vazifesi görmekte ve iletişimin var olduğu alanda
tasarımda etkileşimle bağlantılı bir ilişki içerisine girmektedir. Bilgisayar ve iletişim teknolojilerinde meydana
gelen yenilikler etkileşim kavramının çalışma alanının genişleyerek, hayatın merkezine ilerleyip yaygınlaşmasına
sebep olmuş ve bu durum, bu kavramın farklı başlıklar altında ele alınmasını sağlamıştır. Bu başlıklardan bir
tanesi olan etkileşimli infografik, kullanıcıya fazla bilginin sunulması imkanını sağlayan ve aynı zamanda onlara
veri üzerinde kontrol imkanı sunarak, kendilerine sunulan bilgiyi hızlı anlayabilmelerini amaçlayan ortamlardır.
Kurulan etkileşimin sağlıklı ve anlaşılır bir biçimde kurgulanmasında tasarım süreci, hedef kitlenin algı düzeyine
göre işlevsel bir çalışma ortaya koyulması açısından önemlidir. Bu süreçle birlikte tasarımın oluşturulmasında
kullanılan gestalt ilkeleri, kullanıcıların tasarım ortamındaki farklı elemanları birbirleri ile ilişkilendirebildikleri
etkili ve verimli bir tasarım ortamı oluşturulabilmesinde önemli rol oynamaktadır. Bu çalışmada öncelikle
etkileşim tasarımında gestalt algı ilkeleri ve tasarım geliştirme süreci üzerinde durulmuş ve ele alınan etkileşimli
infografik uygulamalar, bu ilkeler ve etkileşim tasarım süreci ışığında değerlendirilmiştir. Etkileşimli infografikte
tasarım geliştirme sürecinin ve gestalt algı ilkelerinin önemini ortaya koymak amaçlanmıştır, bu noktada
çalışmanın literatüre katkıda bulunacağı düşünülmektedir.
Interleukin 17 and Its Involvement in Renal Cell Carcinoma
Authors: Jarocki Michał , Karska Julia , Kowalski Szymon , Kiełb Paweł , Nowak Łukasz , Krajewski Wojciech , Saczko Jolanta , Kulbacka Julita , Szydełko Tomasz , Małkiewicz Bartosz 
Published: June 2022

Nowadays molecular and immunological research is essential for the better understanding of tumor cells pathophysiology. The increasing number of neoplasms is taken under ‘the molecular magnifying glass’ therefore it is possible to discover complex relationships between cytophysiology and immune system action. An example could be renal cell carcinoma (RCC) which has deep interactions with immune mediators such as Interleukin 17 (IL-17) - an inflammatory cytokine reacting to tissue damage and external pathogens. RCC is one of the most fatal urological cancer because of its often late diagnosis and poor susceptibility to therapies. IL-17 and its relation with tumors is extremely complex and constitute a recent topic for numerous research. What is worth highlighting is IL-17 dual character in cancer development - it could be pro- as well as antitumorigenic. The aim of this review is to summarize the newest data considering multiple connections between IL-17 and RCC.
Revision Risk for Total Knee Arthroplasty Polyethylene Designs in Patients 65 Years of Age or Older
Authors: Kendall Jamil , Pelt Christopher E. , Imlay Benjamin , Yep Patrick , Mullen Kyle , Kagan Ryland 
Published: June 2022

Background:
Polyethylene bearing design may influence the risk of revision after total knee arthroplasty (TKA). Previous investigations from outside of the United States have suggested the potential for an increased risk of all-cause revision and revision for infection with the use of posterior-stabilized bearings. We examine the risk of revision based on the polyethylene bearing design selection for primary TKA.

Methods:
An analysis of the American Joint Replacement Registry (AJRR) data from 2012 to 2019 was performed. We identified all primary TKAs over the study period and linked cases to supplemental U.S. Centers for Medicare & Medicaid Services (CMS) data where available. Patient demographic characteristics, polyethylene characteristics, procedure dates, and cause for revision were recorded. Analysis was performed to compare minimally stabilized implants (cruciate-retaining, anterior-stabilized, or pivot bearing designs) with posterior-stabilized implants. Cumulative incidence function (CIF) curves and Cox proportional hazard ratios (HRs) were created for all-cause revision and revision for infection in each group.

Results:
We identified 305,279 cases with reported minimally stabilized or posterior-stabilized implant characteristics. There were 161,486 cases (52.9%) that utilized posterior-stabilized bearings compared with 143,793 cases (47.1%) with minimally stabilized bearings. For minimally stabilized bearings, 1,693 cases (1.18%) had all-cause revision and 334 cases (0.23%) had revision for infection. For posterior-stabilized bearings, 2,406 cases (1.49%) had all-cause revision and 446 cases (0.28%) had revision for infection. The use of posterior-stabilized bearings had HRs of 1.25 (95% confidence interval [CI], 1.2 to 1.3; p < 0.0001) for all-cause revision and 1.18 (95% CI, 1.0 to 1.4; p = 0.02) for revision for infection.

Conclusions:
Similar to investigations from international registries, we found an increased risk of all-cause revision and revision for infection when using posterior-stabilized bearings in TKA in the United States. Surgeons should consider this finding when considering bearing selection for primary TKA.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Understanding Noise Exposure During Cast Removal
Authors: Shaw K. Aaron , Mueller Casey , Biolzi Francesco , Villani Nolan , O’Brien Frederick , Burks Robert 
Published: June 2022

Background:
Cast removal can be associated with considerable noise exposure, especially impacting the pediatric patient and provider. Although noise generation from cast saws has been deemed safe by the U.S. Occupational Safety and Health Administration and the U.S. Centers for Disease Control and Prevention standards, there are no current studies on the effects of cast material on noise levels generated.

Methods:
A simulated casting model utilizing plaster, fiberglass, and plaster with fiberglass overwrapping was used for experimental testing. Four different casting conditions were tested, with 5 samples in each group. Samples were tested using 2 different cast saws: a standard cast saw and a quiet saw. Each saw was used for 30 seconds of continuous cutting for each sample, measuring peak, mean, and minimum sound levels in decibels with sound level meters. Noise levels were measured at 18, 36, and 72 in (20, 91, and 183 cm) from the saw, comparing saw and cast types against ambient noise and baseline cast-saw noises. Between-group comparisons were performed using univariate analyses.

Results:
Mean noise generation differed between casting materials, with plaster material demonstrating significantly greater noise levels than fiberglass casts at all distances for each saw type. Increasing fiberglass thickness significantly increased the mean noise levels with standard (18-in distance for 10 and 5 ply: 87.4 and 85.8 dB; p = 0.0004) and quiet cast saws (78.3 and 76.1 dB; p = 0.041. Additionally, the quiet cast saw provided a 5.7 to 10.6 dB reduction in mean and peak noise levels, varying by casting material and distance.

Conclusions:
Occupational noise exposure can be mitigated with the use of fiberglass casting material that is not >5 ply in thickness, with a quiet cast saw for removal. The use of a quiet cast saw substantially decreased noise exposure to patients and staff members over standard orthopaedic cast saws.
Spinal Compared with General Anesthesia in Contemporary Primary Total Hip Arthroplasties
Authors: Owen Aaron R. , Amundson Adam W. , Fruth Kristin M. , Duncan Christopher M. , Smith Hugh M. , Johnson Rebecca L. , Taunton Michael J. , Pagnano Mark W. , Berry Daniel J. , Abdel Matthew P. 
Published: June 2022

Background:
The specific advantages of spinal anesthesia compared with general anesthesia for primary total hip arthroplasty (THA) remains unknown. Therefore, this study aimed to investigate the pain control, length of stay, and postoperative outcomes associated with spinal anesthesia compared with general anesthesia in a large cohort of primary THAs from a single, high-volume academic institution.

Methods:
We retrospectively identified 13,730 primary THAs (11,319 patients) from 2001 to 2016 using our total joint registry. Of these cases, 58% had general anesthesia and 42% had spinal anesthesia. The demographic characteristics were similar between groups, with mean age of 64 years, 51% female, and mean body mass index (BMI) of 31 kg/m2. Data were analyzed using an inverse probability of treatment weighted model based on a propensity score that accounted for numerous patient and operative factors. The mean follow-up was 6 years.

Results:
Patients treated with spinal anesthesia had lower Numeric Pain Rating Scale (NPRS) scores (p < 0.001) and required fewer postoperative oral morphine equivalents (OMEs) at all time points evaluated (p < 0.001). Patients treated with spinal anesthesia also had shorter hospital length of stay (p = 0.02), fewer altered mental status events (odds ratio [OR], 0.7; p = 0.02), and fewer intensive care unit (ICU) admissions (OR, 0.7; p = 0.01). There was no difference in the incidence of deep vein thrombosis (p = 0.8), pulmonary embolism (p = 0.4), 30-day readmissions (p = 0.17), 90-day readmissions (p = 0.18), all-cause revisions (p = 0.17), or all-cause reoperations (p = 0.14).

Conclusions:
In this large, single-institution study, we found that spinal anesthesia was associated with reduced pain scores and OME use postoperatively. Furthermore, spinal anesthesia resulted in fewer altered mental status events and ICU admissions. These data favor the use of spinal anesthesia in primary THAs.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Optimizing the radiation treatment planning of brain tumors by integration of Functional MRI and White Matter Tractography
Authors: Boroun Arman , Montazerabadi Alireza , Molana Seyed Hadi , Gholamhosseinian Hamid , Pashaei Fakhereh 
Published: June 2022

Abstract
Purpose: The purpose of this study was to assess whether the incorporation of functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) data into the radiation treatment planning process of brain tumors could spare the neurological parts of the brain from high doses of radiation.Methods: In this study, the fMRI and DTI data were obtained from eight glioma patients and included in the radiation treatment plan‏. This patient-specific fMRI and DTI data were attained based on tumor location, patient's general conditions, and the importance of the functional and fiber tract areas. The functional regions, fiber tracts, anatomical organs at risk, and the tumor were contoured for radiation treatment planning. Finally, the radiation treatment planning with and without fMRI & DTI information was obtained and compared.Results: On average, the mean dose to the functional areas was reduced by 25.36%, and the maximum dose was reduced by 18.57% on fMRI & DTI plans compared with the anatomical plans In addition, 15.59% and 20.84% reductions in the mean and maximum doses of the fiber tracts were achieved, respectively.Conclusion: This study demonstrated the feasibility of using fMRI and DTI data in radiation treatment planning to maximize radiation protection of the functional cortex and fiber tracts. We also observed a significant reduction in the mean and maximum doses to these neurologically relevant brain regions. Dose reduction would reduce the neuro-cognitive complications and improve the patient's quality of life.
Brain Activity during Working Memory Tasks after Daily Caffeine Intake: a randomized double-blind placebo-controlled trial
Authors: Lin Yu-Shiuan , Weibel Janine , Landolt Hans-Peter , Santini Francesco , Slawik Helen , Borgwardt Stefan , Cajochen Christian , Reichert Carolin 
Published: June 2022

Abstract
Caffeine has been reported to acutely increase working memory (WM)-related brain activity without a significant enhancement in performances in healthy adults. As a ritual in the society, however, the impacts of daily caffeine intake on WM-related brain activities remain unknown. This double-blind randomized crossover study aimed to investigate the blood-oxygen-level-dependent (BOLD) activity in 20 young healthy non-smokers (age: 26.4 ± 4.0 years; body mass index: 22.7 ± 1.4 kg/m2; and self-report habitual caffeine intake: 474.1 ± 107.5 mg/day) during WM tasks (consisting high and low workloads) after 10-day caffeine intake (150 mg x 3/day) and after 36h withdrawal (9-day caffeine & 1-day placebo) compared to 10-day placebo intake (150 mg x 3/day). In caffeine condition, participants showed more errors and longer reaction times (RTs) in WM tasks, without significant changes in the workload-dependent BOLD activities. Worse WM performance remained after acute withdrawal. Furthermore, independent of workloads, BOLD activity was reduced in hippocampus in caffeine but partially mitigated in withdrawal condition. No significant differences in simple attention tasks were observed between caffeine and placebo, while withdrawal showed longer RTs than the other two. Taken together with the earlier evidence, caffeine might acutely increase the demands of cerebral metabolic activities for WM, which however could no longer be fulfilled after daily intake and results in compromised performances. The reduced hippocampal activities additionally echoed the caffeine-reduced grey matter volume previously reported. This study is funded by Swiss National Science Foundation (grant 320030 − 163058).
Impact of Women’s Knowledge, Perception and Attitude towards Cervical Cancer Screening in South West Nigeria
Authors: Owolabi Gbonjubola Oludayo , Jegede Ayodele Samuel , Kolade Oluwaseun , Oghinan Paul 
Published: June 2022

Abstract
Objectives: Although cancer of the cervix is a preventable disease and services associated to cervical cancer screening has proven to drastically reduce morbidity and mortality. This study aimed to investigate the impact of women’s knowledge, perception and attitude towards Cervical Cancer Screening in South West Nigeria. There is low uptake of Cervical cancer screening (CCS) in developing countries. In the same vein, preventive services are unorganised, sporadic and often expensive. Method: This study draws from a cross-sectional survey of 117 respondents from purposively selected rural and urban locations in southwest Nigeria to investigate the impact of awareness, attitudes, risk perception and socio-economic variables on CCS uptake.Results: The results of the descriptive statistics, Chi-square tests and regression analyses show that awareness and education level are significantly associated with CCS uptake. The respondent’s level of knowledge of signs and symptoms of cervical cancer is low. Conclusion: The findings underline the importance of awareness and enlightenment campaign as a key factor to drive CCS uptake. Furthermore, health care practitioners need to be actively engaged in the design and implementation of interventions. Finally, governments need to invest resources and funding to make CCS accessible and affordable in order to reduce both morbidity and mortality.
Effects of Sweet Potato Intercropping in Banana Orchard on Soil Microbial Population Diversity
Authors: Li yanpei , Lin Jiaqi , Xiao Shixiang , Feng Dou , Deng Yingyi , xuan weiyan 
Published: June 2022

Abstract
Purpose
This study was purposely designed to understand the effects of intercropping banana and sweet potato on soil microbial community. The research question addressed was what were the differences in population number, population diversity and dominant population of soil microorganisms between interplant bananas with sweet potatoes and banana monoculture.
Methods
The Illumina MiSeq high-throughput sequencing technology was used to detect and analyse the population composition and structure of soil microorganisms in banana field.
Results
The results showed that from May to September, the number of soil bacterial population in intercropping sweet potato was 5.54–28.67% higher than that in monoculture, and the richness and diversity of the population were significantly or extremely significantly higher than that in monoculture. The number of dominant bacterial population was less than that in monoculture, and the relative abundance of non dominant population was 10.58–58.81% higher than that in monoculture. The number, abundance and diversity of soil fungal populations in intercropping were higher than those in monoculture.
Conclusions
The intercropping of banana and sweet potato has a significant effect on regulating the composition structure of soil microbial population and improving the abundance and diversity of microbial population. There has a great significance to improve the micro ecological environment of banana root soil and promote the stable and sustainable development of banana industry.
Fitness-for-purpose of the CanMEDS competencies for workplace-based assessment in General Practitioner’s Training: a Delphi study
Authors: Andreou Vasiliki , Peters Sanne , Eggermont Jan , Embo Mieke , Michels Nele R. , Schoenmakers Birgitte 
Published: June 2022

Abstract
Background
In view of the exponential use of the CanMEDS framework along with the lack of rigorous evidence about its applicability in workplace-based medical trainings, further exploring is necessary before accepting the framework as valid and reliable competency outcomes for postgraduate medical trainings. Therefore, this study investigated whether the CanMEDS key competencies could be used as outcome measures for assessing trainees’ competence and for supporting competency growth across training phases in a workplace-based General Practitioner’s (GP) Training setting.
Methods
A web-based Delphi study was employed to collect validity evidence. In three Delphi rounds, a panel of experts (n = 25–43) was asked to rate on a 5-point Likert scale whether the CanMEDS key competencies were feasible for workplace-based assessment, and consistent for assessment across different training phases. Comments on each CanMEDS key competency were encouraged. Descriptive statistics of the ratings were calculated, while content analysis was used to categorise panellists’ comments.
Results
Out of twenty-seven CanMEDS key competencies, 21 were scored as feasible, and 16 as consistent across training phases for assessment in the workplace. All the key competencies under the “Medical Expert”, “Communicator”, and “Collaborator” roles reached consensus for feasibility of assessment. The panel also agreed on one out of four key competencies under the role “Leader”, one out of two competencies under the role “Health Advocate”, three out of four competencies under the role “Scholar”, and three out of four competencies for the role “Professional”. Regarding consistency of assessment in the workplace, consensus was achieved for four out of five competencies under “Medical Expert”, three out of five competencies under “Communicator”, two out of three competencies under “Collaborator”, one competency out of two under “Health Advocate”, three out of four competencies under “Scholar”, three out of four competencies under “Professional”. No competency under the role “Leader” deemed to be consistently assessed across training phases.
Conclusions
The findings indicate a mismatch between the initial intent of the CanMEDS framework and its applicability in the context of workplace-based assessment. Although the CanMEDS framework could offer starting points, further contextualization of the framework is required before implementing in postgraduate medical trainings.
Impacts of X-linked retinitis pigmentosa and patient pathways in European countries: results from the cross-sectional EXPLORE XLRP-1 physician survey
Authors: Pungor Katalin , Lee Jennifer , Denee Tom , Kambarov Yerkebulan , Nissinen Riikka , Ampeh Kevin , Pellegrini Marco , Parmeggiani Francesco 
Published: June 2022

Abstract

Retina specialists (n = 20) and geneticists (n = 5) in France, Germany, Italy, Spain, and the United Kingdom were interviewed to provide insights on real-world patients (n = 80) with X-linked retinitis pigmentosa (XLRP). Survey respondents reported that their patients with XLRP often required assistance as their independence decreased over time, from 37% being “completely autonomous” at diagnosis (2% were “completely dependent” on family/friends), to 23% at their most recent consultation (10% were “completely dependent”). At their last visit, 45% of patients were active in the workforce. Workforce participation was related to independence/autonomy; 67% of “completely autonomous” patients were active, compared with 13% of “completely dependent” patients. The pathways by which patients with XLRP in these five countries visit retina specialists and geneticists are complex, lengthy, and vary considerably by country. Physicians reported high usage of genetic testing to confirm XLRP diagnosis (77.5%); however, long waiting times for test results account for incomplete uptake, especially among older patients. Teleconsultations and remote management have emerged as potential solutions for monitoring patients during the COVID-19 pandemic. Physicians report that unmet needs in XLRP management include more standardized assessment of quality of life; easier and earlier access to specialists, genetic testing, patient support programs, and effective treatment options.