bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineering Covalent Organic Frameworks with Polyethylene Glycol as Self‐Sustained Humidity‐Responsive Actuators
Authors: Mao Tianhui , Liu Zhaoyi , Guo Xiuxiu , Wang Zhifang , Liu Jinjin , Wang Ting , Geng Shubo , Chen Yao , Cheng Peng , Zhang Zhenjie 
Published: November 2022

AbstractRegarding the global energy crisis, it is of profound significance to develop spontaneous power generators that harvest natural energy. Fabricating humidity‐responsive actuators that can conduct such energy transduction is of paramount importance. Herein, we incorporate covalent organic frameworks with flexible polyethylene glycol to fabricate rigid‐flexible coupled membrane actuators. This strategy significantly improves the mechanical properties and humidity‐responsive performance of the actuators, meanwhile, the existence of ordered structures enables us to unveil the actuation mechanism. These high‐performance actuators can achieve various actuation applications and exhibit interesting self‐oscillation behavior above a water surface. Finally, after being coupled with a piezoelectric film, the bilayer device can spontaneously output electricity over 2 days. This work paves a new avenue to fabricate rigid‐flexible coupled actuators for self‐sustained energy transduction.
Synthesis of phenolphthalein/bisphenol A‐based poly(arylene ether nitrile) copolymers: Preparation and properties of films
Authors: Li Jingcheng , Zhang Shuai , Liu Xiaobo 
Published: November 2022

AbstractPoly(arylene ether nitrile) (PEN) is a class of high‐performance engineering plastics of poly(arylene ether) with cyano groups as side groups, which can get improved thermal, mechanical, and electrical properties through simple molecular structure design. In this work, a series of PEN (BPA/PP based PEN) copolymers were synthesized with varying amounts of phenolphthalein and bisphenol A. The influence of the copolymer molecular structure variations on the thermal, mechanical, and dielectric properties of PEN copolymer films was investigated. The results demonstrated that the BPA/PP based PEN copolymer films have great mechanical properties and low dielectric constant, as well as enhanced thermal properties. The highest 5% weight loss temperature of 494.9°C was obtained by PEN‐B7P3, while the highest glass transition temperature of 238.6°C was obtained by PEN‐B3P7. Porous BPA/PP based PEN films prepared by non‐solvent induced phase separation (NIPS) exhibited satisfactory mechanical properties and the highest tensile strength of 9.4 MPa was achieved. Moreover, the introduction of the phenolphthalein structure into the PEN molecular chain can improve the heat resistance of the PEN copolymers without deteriorating the dielectric properties, which gives the copolymers great potential as candidates for applications in flexible electronics and wireless communication.
F3‐functionalized nanoscale metal–organic frameworks for tumor‐targeting combined chemotherapy and chemodynamic therapy
Authors: Liu Jia , Cong Yiyang , Zeng Yawen , He Yiming , Luo Ying , Lu Weifei , Xu Haixing , Yin Yihua , Hong Hao , Xu Wenjin 
Published: November 2022

AbstractNanoscale metal–organic frameworks (nMOFs) have attracted much attention as emerging porous materials as drug delivery carriers. Appropriate surface modification of them can greatly improve stability and introduce biocompatibility and cancer targeting functionality into drug delivery systems. Herein, we prepared nano‐sized MIL‐101(Fe)‐N3 and loaded anticancer drug doxorubicin (DOX) into it. The synthetic polymer layer Alkyne‐PLA‐PEG was then attached to the F3 peptide (labeled as Alkyne‐PLA‐PEG‐F3), and the surface of DOX/MIL‐101(Fe)‐N3 was covalently modified with it to obtain DOX/MIL‐101‐PLA‐PEG‐F3. Nano‐sized MIL‐101(Fe)‐N3 has high drug loading capacity and the modification of MIL‐101(Fe)‐N3 by polymer Alkyne‐PLA‐PEG not only improved the dispersion, but also avoided the sudden release of the drugs and increased the biocompatibility of nanocarriers. The F3 peptide introduced into the nanocarriers also enabled it to specifically target tumor tissues and achieved active targeted drug delivery. As a nucleolin‐mediated endocytosis drug delivery system, DOX/MIL‐101‐PLA‐PEG‐F3 can not only deliver anticancer drugs to tumors accurately, but also participate in Fenton‐like reaction to generate hydroxyl radicals (•OH) for chemodynamic therapy (CDT), thus enabling combination therapy. It holds great promise as drug candidates to reduce systemic toxicity and improve the efficacy of cancer treatment.
Effect of the nanoparticles on the morphology and mechanical performance of thermally blown 3D printed HIPS foams
Authors: Zarybnicka Klara , Lepcio Petr , Svatik Juraj , Jancar Josef , Ondreas Frantisek 
Published: November 2022

AbstractCellular polymer nanocomposites can combine high mechanical performance with low density. However, the manufacturing of porous nanocomposites into complex shapes can represent a challenge. Therefore, this article deals with the preparation, characterization, and 3D printing of porous nanocomposites. The filaments were extruded from the polymer nanocomposite filled by thermal chemical blowing agent, and then processed by 3D printing into the required shapes. In‐situ and post‐treatment foaming strategies were investigated and compared. The nanoparticles (NPs) significantly affected the processing, structure, thermal and mechanical properties of polymeric foams. The NPs, serving as a nucleating agent, allowed preparation of smaller pores and led to finer and more homogeneous foams. At the same time, they reinforced foam walls and thus improved mechanical properties. Moreover, NPs catalyzed decomposition of the blowing agent grains at lower temperature which brought about faster and more efficient foaming. This study showed the straightforward approach to prepare mechanically robust lightweight 3D printed materials.
Diversity and Clonality of T Cell Receptor Repertoire and Antigen Specificities in Small Joints of Early Rheumatoid Arthritis
Authors: Turcinov Sara , af Klint Erik , Van Schoubroeck Bertrand , Kouwenhoven Arlette , Mia Sohel , Chemin Karine , Wils Hans , Van Hove Carl , De Bondt An , Keustermans Ken , Van Houdt Jeroen , Reumers Joke , Felix Nathan , Rao Navin L. , Peeters Pieter , Stevenaert Frederik , Klareskog Lars , McKinnon Murray , Baker Daniel , Suri Anish , Malmström Vivianne 
Published: November 2022

ObjectiveCD4+ T cells are implicated in rheumatoid arthritis (RA) pathology from the strong association between RA and certain HLA class II gene variants. This study was undertaken to examine the synovial T cell receptor (TCR) repertoire, T cell phenotypes, and T cell specificities in small joints of RA patients at time of diagnosis before therapeutic intervention.MethodsSixteen patients, of whom 11 patients were anti–citrullinated protein antibody (ACPA)–positive and 5 patients were ACPA–, underwent ultrasound‐guided synovial biopsy of a small joint (n = 13) or arthroscopic synovial biopsy of a large joint (n = 3), followed by direct sorting of single T cells for paired sequencing of the αβ TCR together with flow cytometry analysis. TCRs from expanded CD4+ T cell clones of 4 patients carrying an HLA–DRB1*04:01 allele were artificially reexpressed to study antigen specificity.ResultsT cell analysis demonstrated CD4+ dominance and the presence of peripheral helper T–like cells in both patient groups. We identified >4,000 unique TCR sequences, as well as 225 clonal expansions. Additionally, T cells with double α‐chains were a recurring feature. We identified a biased gene usage of the Vβ chain segment TRBV20‐1 in CD4+ cells from ACPA+ patients. In vitro stimulation of T cell lines expressing selected TCRs with an extensive panel of citrullinated and viral peptides identified several different virus‐specific TCRs (e.g., human cytomegalovirus and human herpesvirus 2). Still, the majority of clones remained orphans with unknown specificity.ConclusionMinimally invasive biopsies of the RA synovium allow for single‐cell TCR sequencing and phenotyping. Clonally expanded, viral‐reactive T cells account for part of the diverse CD4+ T cell repertoire. TRBV20‐1 bias in ACPA+ patients suggests recognition of common antigens.image
Bias against scientific novelty: A prepublication perspective
Authors: Liang Zhentao , Mao Jin , Li Gang 
Published: November 2022

AbstractNovel ideas often experience resistance from incumbent forces. While evidence of the bias against novelty has been widely identified in science, there is still a lack of large‐scale quantitative work to study this problem occurring in the prepublication process of manuscripts. This paper examines the association between manuscript novelty and handling time of publication based on 778,345 articles in 1,159 journals indexed by PubMed. Measuring the novelty as the extent to which manuscripts disrupt existing knowledge, we found systematic evidence that higher novelty is associated with longer handling time. Matching and fixed‐effect models were adopted to confirm the statistical significance of this pattern. Moreover, submissions from prestigious authors and institutions have the advantage of shorter handling time, but this advantage is diminishing as manuscript novelty increases. In addition, we found longer handling time is negatively related to the impact of manuscripts, while the relationships between novelty and 3‐ and 5‐year citations are U‐shape. This study expands the existing knowledge of the novelty bias by examining its existence in the prepublication process of manuscripts.
Surface Coating of Amorphous TiOx Enables Efficient Vapor‐fed Photocatalytic Overall Water Splitting with Substantial Apparent Quantum Yield
Authors: Zhao Meng , Zhang Guigang 
Published: November 2022

AbstractPhotocatalytic overall water splitting represents a promising strategy for sustainable hydrogen production. However, photocorrosion and dissolution of photocatalysts and cocatalysts are common concern for the solid‐liquid phase reaction. Recently, the above issues could be addressed by Domen and coworkers, when the photocatalytic water splitting was conducted in the presence of water vapor, which dramatically restrain the undesired corrosion of the photocatalysts and cocatalysts. Besides, surface decoration of hygroscopic TiOx layer promotes adsorption of water molecules and prevents the corrosion process. In addition, vapor‐fed photocatalytic water splitting remains considerable apparent quantum yield compared with the liquid water photocatalytic overall water splitting at pressurized condition, which endows great potential in practical application.
Marrying a Non‐Flammable Phosphate Solvent with Lithium Nitrate: Novel Electrolyte for Intrinsically Safe and High Performance Lithium Metal Batteries
Authors: Dinh Nguyen Hieu , Duong Pham Thuy , Bin Faheem Abdullah , Min Oh Hye , Lee Kyung‐Koo 
Published: November 2022

AbstractThe formation of lithium (Li) dendrites and deterioration of the mechanical integrity of Nickel (Ni)‐rich cathodes directly hinder the commercialization of high‐voltage Li metal batteries (LMBs) with Ni‐rich cathodes. Herein, a novel electrolyte was tailored by combining non‐flammable triethyl phosphate (TEP) solvent with easily‐synthesized lithium nitrate (LiNO3) as the main salt and fluoroethylene carbonate (FEC) additive. The preferential electrochemical decomposition of LiNO3 and FEC provides robust and conductive solid/cathode electrolyte interphase (SEI/CEI) layer on the surface of the anode/cathode, which can protect both electrodes effectively during long‐term cycling. Benefiting from the synergetic effect of LiNO3 and FEC, NFE−LiNO3 exhibited outstanding performances in the cells with LiNi0.6Mn0.2Co0.2O2 (Li||NMC622) under high voltage (4.3 V), achieving an extremely high average efficiency of ∼100 % with an exceptional capacity retention of 90 % after 250 cycles. This study provides useful insights into the rational design of highly efficient, non‐flammable, and low‐cost electrolyte for long‐lasting high‐voltage LMBs.
Transcriptome analysis of Sf9 insect cells during production of recombinant Adeno‐associated virus
Authors: Virgolini Nikolaus , Hagan Ryan , Correia Ricardo , Silvano Marco , Fernandes Sofia , Alves Paula M. , Clarke Colin , Roldão António , Isidro Inês A. 
Published: November 2022

AbstractThe insect cell‐baculovirus expression vector system (IC‐BEVS) has emerged as an alternative time‐ and cost‐efficient production platform for recombinant Adeno‐associated virus (AAV) for gene therapy. However, a better understanding of the underlying biological mechanisms of IC‐BEVS is fundamental to further optimize this expression system toward increased product titer and quality. Here, gene expression of Sf9 insect cells producing recombinant AAV through a dual baculovirus expression system, with low multiplicity of infection (MOI), was profiled by RNA‐seq. An 8‐fold increase in reads mapping to either baculovirus or AAV transgene sequences was observed between 24 and 48 h post‐infection (hpi), confirming a take‐over of the host cell transcriptome by the baculovirus. A total of 336 and 4784 genes were identified as differentially expressed at 24 hpi (vs non‐infected cells) and at 48 hpi (vs. infected cells at 24 hpi), respectively, including dronc, birc5/iap5, and prp1. Functional annotation found biological processes such as cell cycle, cell growth, protein folding, and cellular amino acid metabolic processes enriched along infection.This work uncovers transcriptional changes in Sf9 in response to baculovirus infection, which provide new insights into cell and/or metabolic engineering targets that can be leveraged for rational bioprocess engineering of IC‐BEVS for AAV production.
Organisations' contributions to sustainability. An analysis of impacts on the Sustainable Development Goals
Authors: Lozano Rodrigo , Barreiro‐Gen Maria 
Published: November 2022

AbstractOrganisations have been driving sustainability, where some efforts have focussed on the organisation itself and some on how organisations contribute to society, such as addressing the Sustainable Development Goals (SDGs). Although organisations have been working to address the SDGs, there has been limited integration of the SDGs in organisation systems. This paper aimed at analysing how organisations have been addressing the SDGs. A survey was developed to investigate the impacts and contribution of organisations to sustainability, where 294 responses were obtained for the questions on organisations' impacts to the sustainability. The data were analysed using descriptive analysis: Friedman test to rank the impacts on the SDGs and divided into quartiles; a ratio analysis between positive impacts and negative impacts; and correlations. The results show that organisations' impacts on the SDGs are quite generalisable to all types of organisations, with three exceptions (SDGs 4, 5 and 16). The results also served to develop an SDG impact categorisation. The correlation analysis showed that organisations address the SDGs through a compartmentalised approach. The results helped to propose the ‘organisations' impacts on the SDGs framework’ focussing on the contribution of organisations to sustainability. This research shows that organisations can contribute directly to some of the SDGs, but not to others. Therefore, the discourse must change from integration of SDGs on organisations to the contribution that organisations can have on the SDGs.
Development of a Transcriptional Activator‐Like Effector Protein to Accurately Discriminate Single Nucleotide Difference
Authors: Sakono Masafumi , Oya Takuma , Aoki Mio 
Published: November 2022

AbstractTranscriptional activator‐like effector (TALE), a DNA‐binding protein, is widely used in genome editing. However, the recognition of the target sequence by the TALE is adversely affected by the number of mismatches. Therefore, the association constant of DNA‐TALE complex formation can be controlled by appropriately introducing a mismatch into the TALE recognition sequence. This study aimed to construct a TALE that can distinguish a single nucleotide difference. Our results show that a single mismatch present in repeats 2 or 3 of TALE did not interfere with the complex formation with DNA, whereas continuous mismatches present in repeats 2 and 3 significantly reduced association with the target DNA. Based on these findings, we constructed a detection system of the one nucleotide difference in gene with high accuracy and constructed a TALE‐nuclease (TALEN) that selectively cleaves DNA with a single mismatch.
RASSF1A inhibits epithelial–mesenchymal transition of gastric cancer cells by downregulating P‐JNK
Authors: Bin Yuling , Deng Wenbing , Hu Hongsai , Zeng Qiong , Chen Juan , Xu Yanqing , Dai Yong , Liao Aijun , Xiao Weisheng 
Published: November 2022

AbstractGastric cancer (GC) is one of the most common gastrointestinal tumors. In this study, we assessed the biological role of Ras association domain family 1 isoform A (RASSF1A) in GC cells. Expressions of RASSF1A and the relationship of RASSF1A with epithelial–mesenchymal transformation (EMT)‐related proteins were assessed in five cell lines using Western blot. GC cells with RASSF1A overexpression were used to study sensitivity to cisplatin, migration, invasion, and the expression of EMT‐associated biomarkers. GC cells showed profound downregulation of RASSF1A expression compared with normal human gastric mucosal cells. High RASSF1A expression was associated with increased overall survival. Overexpression of RASSF1A regulates GC cells activity and the expression of EMT‐associated biomarkers. RASSF1A regulates E‐cadherin and Vimentin through P‐JNK pathway. Our results revealed that RASSF1A can inhibit the proliferation, migration, and invasion of GC cells via E‐cadherin. Our study provides insights for further research on GC.
ST‐elevation myocardial infarction after COVID‐19 infection in a young man with Kawasaki disease
Authors: Matsunaga Yuro , Fukamachi Daisuke , Okumura Yasuo , Matsumoto Naoya 
Published: November 2022

AbstractA 22‐year‐old male with a history of Kawasaki disease was admitted to our emergency department with an inferior ST elevation myocardial infarction (STEMI). He was infected with COVID‐19 one month prior to admission, and thereafter, stopped the medication 10 days prior to the STEMI.
Inferior vena cava thrombosis attributable to hyperhomocysteinemia: A case report from Nepal
Authors: Acharya Ramesh , Shrestha Astika , Simkhada Suman , Shrestha Bikash , Shrestha Prajowl , Paudel Byapak , Paudel Sharma 
Published: November 2022

AbstractInferior vena cava thrombosis (IVCT) is a rare complication of deep vein thrombosis (DVT) in the legs. The etiology of IVC thrombosis can be divided into genetic versus nongenetic (environmental/acquired) etiological factors found in Virchow's triad of stasis, endothelial injury, and hypercoagulability. Hyperhomocysteinemia is a rare risk factor for venous thromboembolism and atherosclerotic disease. Hence, very few cases have been described to date to knowledge. A case of a 78‐year‐old hypertensive man who presented with hyperhomocysteinemia‐induced DVT of the left leg extending toward an anatomically normal IVC is discussed in the report.
A lymphatic malformation with a “Lympholith” and encasing neurovascular structures in the arm of a 2‐year‐old child: A case report
Authors: Sharma Samit , Rayamajhi Aadesh , Shrestha Jayan Man 
Published: November 2022

AbstractA 2‐year‐old child presented with a lymphatic malformation (LM) in the arm and the axilla. The neurovascular structures encased by the LM were preserved during the excision surgery, and a “lympholith” was found within a cyst of the LM.
Graves' disease complicated by concurrent thyroid eye disease and pretibial myxedema successfully treated with teprotumumab
Authors: Bowens Brendan K. , Chou Eva , LaChance David P. , Huynh James R. , Voorhees Patrick , Do Thanh C. , Shakir Mohamed K. M. , Hoang Thanh D. 
Published: November 2022

AbstractWe report a 51‐year‐old woman with thyroid eye disease and biopsy‐proven pretibial myxedema that was subsequently treated with teprotumumab with improvement.
Malignant fibroma presenting as a hypoglycemia and coma in a 45‐year‐old male patient: A case report
Authors: Hanif Muhammad , Jaiswal Vikash , Naz Sidra , Patel Nirmit , Pokhrel Nishan Babu , Vadiyala Mounika Reddy 
Published: November 2022

AbstractSolitary fibrous tumors (SFTs) are a rare group of spindle cell neoplasm of submesothelial origin with malignant potential and can present as hypoglycemia secondary to excess secretion of insulin‐like growth factor II (IGF‐II) from the tumor. Early diagnosis and treatment are very important in such cases to prevent hypoxic injury to the brain secondary to hypoglycemia. Here, we are presenting a case of a 45‐year‐old male patient, who presented with recurrent episodes of hypoglycemia spells, and later on, it was diagnosed that hypoglycemic spells were secondary to fibroma.
Poisoning Effects of HCl on MOx‐WO3/TiO2(M=Mn, Ce and V) Catalysts for Selective Catalytic Reduction of NOxby NH3
Authors: Yu Jie , Wang Chizhong , Wang Yazhou , Qiu Lei , Yin Yimeng , Li Xing , Zhao Feilin , Chang Huazhen 
Published: November 2022

AbstractSelective catalytic reduction of NOxby ammonia (NH3‐SCR) was affected by HCl, which was widely present in industrial flue gas. In this study, the SCR performances over MOx‐WO3/TiO2(MW/Ti, M=Mn, Ce and V) catalysts after HCl treatment were investigated. It was found that HCl poisoning showed inhibition and promotion in NOxconversion over MnW/Ti and CeW/Ti catalysts, respectively. While the SCR activity over VW/Ti catalyst was hardly affected by HCl. Over MnW/Ti catalyst, the rupture of the Mn−O bond by the strong Mn−Cl binding induced the formation of amorphous MnCl2species. This Cl‐containing species with Mn in a low oxidation state exhibited poorer redox ability and NO activation, resulting in a decrease in low‐temperature SCR activity. However, instead of directly affecting the CeOxand VOxsites, gaseous HCl reacted with NH3to form NH4Cl species on the surface of CeW/Ti and VW/Ti catalysts. As a result, the SCR activity of VW/Ti catalyst was scarcely influenced by HCl, taking the unchanged redox ability and NH3adsorption. With a further accumulation of NH4Cl on CeW/Ti catalyst, the NOxconversion at low temperature was evidently enhanced due to the promotion in NO‐to‐NO2conversion (Fast‐SCR).
Heavy Chains: Synthesis, Reactivity and Decomposition of Interpnictogen Chains with Terminal Diaryl Bismuth Fragments
Authors: Dunaj Tobias , von Hänisch Carsten 
Published: November 2022

AbstractIn this work, we report the preparation of multiple interpnictogen chain compounds with three consecutive pnictogen atoms and terminal Ar2Bi fragments (Ar=Ph, Mes). Symmetrical compounds of the form Ar2Bi−E(tBu)−Bi2Ar (1: Ar=Ph, E=P; 2: Ar=Ph, Mes, E=As) as well as ternary interpnictogen compounds of the form Ar2Bi−E1(tBu)−E2tBu2 (Ar=Ph, Mes; 4: E1=P, E2=As; 5: E1=P, E2=Sb; 6: E1=As, E2=P) were prepared. The decomposition in solution at room temperature and under the influence of light was studied for compounds 1–6. The reactivity of 1Ph and 2Ph with the small N‐heterocyclic carbene 1,3,4,5‐tetramethylimidazol‐2‐ylidene (Me2IMe) was also studied. In the case of 1Ph, the formation and consecutive decomposition of Me2IMe=PtBu (8) was observed in solution. Hence, it was shown that 1Ph can react as a “masked phosphinidene”. In the case of 2Ph, no reaction with Me2IMe was observed. All isolated compounds were analysed by NMR and IR spectroscopy, mass spectrometry, elemental analysis and single‐crystal X‐ray diffraction.