bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal dose of brexpiprazole for augmentation therapy of antidepressant‐refractory depression: A systematic review and dose‐effect meta‐analysis
Authors: Furukawa Yuki , Oguro Saki , Obata Satomi , Hamza Tasnim , Ostinelli Edoardo G. , Kasai Kiyoto 
Published: June 2022

BackgroundBrexpiprazole augmentation is an effective treatment strategy for antidepressant‐refractory depression, but its optimal dosage remains unclear.AimsTo find the optimal dosage of brexpiprazole as augmentation of other antidepressants.MethodsWe searched multiple electronic databases (from inception to September 16th, 2021) to identify double‐blind, randomized placebo‐controlled fixed‐dose trials evaluating brexpiprazole augmentation therapy in adults (≥18 years old, both genders) with major depressive disorder not adequately responding to one or more antidepressant treatment. Our outcomes of interest at 8 weeks (range 4–12 weeks) were efficacy (treatment response defined as 50% or greater reduction in depression severity), tolerability (dropouts due to adverse effects) and acceptability (dropouts for any reason). We performed a random‐effects, one‐stage dose‐effect meta‐analysis with restricted cubic splines.ResultsSix studies met the inclusion criteria, including 1671 participants in total. The dose‐efficacy curve showed an increase up to doses around 2 mg (odds ratio [OR] 1.52, 95% confidence interval [CI] 1.12–2.06) and then a decreasing trend through the higher licensed dose up to 3 mg (OR 1.40, 95% CI 0.95–2.08). The shape of the dose‐tolerability curve was comparable to that of the efficacy and the dose‐acceptability curve showed a monotonic increasing trend but both had wide confidence bands.ConclusionsOne to two milligrams of brexpiprazole as augmentation treatment may achieve an optimal balance between efficacy, tolerability, and acceptability in the acute treatment of antidepressant‐refractory depression. However, the small number of included studies limit the reliability of the results. Further research is required to validate the findings.
A new well‐being atomism
Authors: Hersch Gil , Weltman Daniel 
Published: June 2022

AbstractMany philosophers reject the view that well‐being over a lifetime is simply an aggregation of well‐being at every moment of one's life, and thus they reject theories of well‐being like hedonism and concurrentist desire satisfactionism. They raise concerns that such a view misses the importance of the relationships between moments in a person's life or the role narratives play in a person's well‐being. In this article, we develop an atomist meta‐theory of well‐being, according to which the prudential value of a life depends solely on the prudential value of each moment of that life. This is a general account of momentary well‐being that can capture different features of well‐being that standard atomistic accounts fail to capture, thus allowing for the possibility of an atomism that is compatible with a variety of well‐being theories. Contrary to many criticisms leveled against momentary well‐being, this well‐being atomism captures all of the important features of well‐being.
Identification and analysis of miRNAs‐lncRNAs‐mRNAs modules involved in stem‐elongation of deepwater rice (Oryza sativa L.)
Authors: Panda Alok Kumar , Rawal Hukam C. , Jain Priyanka , Mishra Vishnu , Nishad Jyoti , Chowrasia Soni , Sarkar Ananda K. , Sen Priyabrata , Naik Soumendra Kumar , Mondal Tapan Kumar 
Published: June 2022

AbstractDeepwater is an abiotic stress that limits rice cultivation worldwide due to recurrent floods. The miRNAs and lncRNAs are two non‐coding RNAs emerging as major regulators of gene expressions under different abiotic stresses. However, the regulation of these two non‐coding RNAs under deepwater stress in rice is still unexplored. In this study, small RNA‐seq and RNA‐seq from internode and node tissues were analyzed to predict deepwater stress responsive miRNAs and lncRNAs, respectively. Additionally, a competitive endogenous RNA (ceRNA) study revealed about 69 and 25 lncRNAs acting as endogenous target mimics (eTM) with the internode and node miRNAs, respectively. In ceRNA analyses, some of the key miRNAs such as miR1850.1, miR1848, and IN‐nov‐miR145 were upregulated while miR159e was downregulated, and their respective eTM lncRNAs and targets were found to have opposite expressions. Moreover, we have transiently expressed one module (IN‐nov‐miR145–Cc‐TCONS_00011544‐Os11g36430.3) in tobacco leaves. The integrated analysis has identified differentially expressed (DE) miRNAs, lncRNAs and their target genes, and the complex regulatory network, which might lead to stem elongation under deepwater stress. In this novel attempt to identify and characterize miRNAs and lncRNAs under deepwater stress in rice, we have provided, probably for the first time, a reference platform to study the interactions of these two non‐coding RNAs with respective target genes through transient expression analyses.
Ontological disagreements, reference, and charity: A challenge for Hirsch's deflationism
Authors: Belleri Delia 
Published: June 2022

AbstractEli Hirsch argues that certain ontological disputes involve a conflict between “equivalent” languages, and that the principle of charity compels each disputant to interpret the other as speaking truly in their own language. For Hirsch, a language's semantics maps sentences (in context) onto sets of possible worlds but assigns no role to reference. I argue that this method leads to an overly uncharitable portrayal of the disputes at issue whereby ontologists who speak “equivalent” languages can only argue about syntax. Lack of charity stems from the fact that this portrayal likely fails to uphold the self‐conception of the disputants – and particularly what I will call theweak self‐conception. As a result, Hirsch's deflationism falls victim of the same principle of charity that informs it.
Epidemiology of indigenous Plasmodium knowlesi infection in Sarawak, 2011–2019
Authors: Ooi Choo Huck , Phang Wei Kit , Liew Jonathan Wee Kent , Atroosh Wahib M. , Lau Yee Ling 
Published: June 2022

AbstractObjectivesTo characterise the state‐wide epidemiology of indigenous knowlesi malaria in Sarawak from 2011 to 2019.MethodsLongitudinal retrospective study was conducted based on Sarawak knowlesi malaria surveillance data recorded from 2011–2019. Only indigenous cases were included and information extracted for analysis comprised age, sex, occupation, ethnicity, case severity, hospital admission and parasite density.ResultsOver the 9 years, 8473 indigenous knowlesi malaria cases were recorded. Age group 40–49 years, males, plantation workers and Iban communities recorded the highest percentage of cases in each demographic variable. Most of the cases were uncomplicated (n = 7292; 86.1%) and 89.6% (n = 7589) of the total cases were reported with ≤20 000 parasites/μl of blood. Age group and ethnic group are associated with the severity of knowlesi malaria in Sarawak. Multivariable logistic regression indicated that the age group 60+ years had the highest odds of developing severe knowlesi malaria compared with other age groups (AOR 2.48; 95% CI 1.22, 5.02; p = 0.012). Bidayuh patients were more likely to develop severe knowlesi malaria than Ibans, the largest ethnic group among knowlesi malaria patients (AOR 1.97; 95% CI 1.31, 2.97; p = 0.001).ConclusionsIdentification of risk groups is important for the implementation of prevention programs and treatments targeting at specific group to combat knowlesi malaria effectively.
Multi-stage construction of the Little Cotton wood stock, Utah, USA: Origin, intrusion, venting, mineralization, and mass movement
Authors: Jensen Collin G. , Christiansen Eric H , Keith Jeffrey D. 
Published: June 2022

AbstractMany porphyry molybdenum deposits are hosted in multi-phase plutons, but it is unclear in some deposits how these magmas originated and whether the pluton intruded as it fractionated or was intruded by new batches of magma. New mapping has clarified field relationships between units in the White Pine porphyry Mo system hosted in the Little Cottonwood stock, Utah (western United States), including the White Pine intrusion, the Red Pine porphyry, rhyolite dikes, and phreatomagmatic pebble dikes. Geologic relations and geochemistry show the system formed in a continental arc setting during rollback of the subducting Farallon slab rather than during extension related to orogenic collapse. Whole-rock geochemistry shows distinct fractionation trends for each of the major intrusive units in the composite pluton, suggesting they formed separately, which is supported by new U-Pb zircon laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS) ages of ca. 30 Ma for the Little Cottonwood stock, 27 Ma for the White Pine intrusion, and 26 Ma for the previously undated Red Pine porphyry. Mineral textures, cross-cutting relationships, and alteration mineralogy indicate that intrusion of the youngest phase led to a fluid-saturated magmatic system and triggered venting, including emplacement of pebble dikes. In the adjacent east Traverse Mountains, pebble dikes contain clasts that have similar mineral assemblages, textures, and ages as the major igneous units in the White Pine deposit. This indicates that the pebble dikes in east Traverse Mountains and in the pluton are the upper and lower parts of the same magmatic-hydrothermal system, which was decapitated by a mega-landslide that was likely facilitated by alteration in the Oligocene hydrothermal system and by later Basin and Range faulting.
Massive white dwarfs in $$f(\mathtt {R,L_m})$$ gravity
Authors: Lobato R. V. , Carvalho G. A. , Kelkar N. G. , Nowakowski M. 
Published: June 2022

AbstractIn this work, we investigate the equilibrium configurations of massive white dwarfs (MWD) in the context of modified gravity, namely $$f(\mathtt {R,L_m})$$

f
(
R
,

L
m

)

gravity, where $$\mathtt {R}$$
R
stands for the Ricci scalar and $$\mathtt {L_m}$$

L
m

is the Lagrangian matter density. We focused on the specific case $$f(\mathtt {R,L_m})= \mathtt {R}/2 + \mathtt {L_m}+ \sigma \mathtt {R}\mathtt {L_m}$$

f

(
R
,

L
m

)

=
R
/
2
+

L
m

+
σ
R

L
m

, i.e., we have considered a non-minimal coupling between the gravity field and the matter field, with $$\sigma $$
σ
being the coupling constant. For the first time, the theory is applied to white dwarfs, in particular to study massive white dwarfs, which is a topic of great interest in the last years. The equilibrium configurations predict maximum masses which are above the Chandrasekhar mass limit. The most important effect of the theory is to increase significantly the mass for stars with radius < 2000 km. We found that the theory can accommodate the super-Chandrasekhar white dwarfs for different star compositions. Apart from this, the theory recovers the General Relativity results for stars with radii larger than 3000 km, independent of the value of $$\sigma $$
σ
.
Charmonium suppression in ultra-relativistic proton–proton collisions at LHC energies: a hint for QGP in small systems
Authors: Singh Captain R. , Deb Suman , Sahoo Raghunath , Alam Jan-e 
Published: June 2022

AbstractProton–proton (pp) collision has been considered as a baseline to study the system produced in relativistic heavy-ion (AA) collisions with the basic assumption that no thermal medium is formed in pp collisions. This warrants a cautious analysis of the system produced in pp collisions at relativistic energies. In this work we investigate the charmonium suppression in pp collisions at $$\sqrt{s} = 5.02$$

s

=
5.02

, 7 and 13 TeV energies. Further, charmonium suppression has been studied for various event multiplicities and transverse momenta by including the mechanisms of color screening, gluonic dissociation, collisional damping along with regeneration due to correlated $$c{\bar{c}}$$

c

c

¯

pairs. Here we obtain a net suppression of charmonia at high-multiplicity events indicating the possibility of the formation of quark–gluon plasma in pp collisions.
Revisiting mono-tau tails at the LHC
Authors: Jaffredo Florentin 
Published: June 2022

AbstractWe revisit the constraints on semileptonic operators derived from the mono-$$\tau $$
τ
high-$$p_T$$

p
T

events in pp collisions at LHC. Like in previous studies, we obtain limits on the New Physics couplings from the CMS data much stronger than from the ATLAS data, despite a nearly equal integrated luminosity. We find that a neglected systematics on the $$\tau $$
τ
lepton reconstruction efficiency can partly explain that difference. We then provide new limits on the New Physics couplings relevant to decays based on $$b\rightarrow c\tau {\bar{\nu }}$$

b
→
c
τ

ν

¯

by using the recent ATLAS data with $$139\,\mathrm{fb}^{-1}$$

139

fb

-
1

. We also show that the inclusion of propagation of the New Physics particle can significantly worsen the bounds obtained by relying on Effective Field Theoretical treatment of New Physics.
Plasma Spectroscopy on Hydrogen-Carbon-Oxygen Foam Targets Driven by
Laser-Generated Hohlraum Radiation
Authors: Ma Bubo , Ren Jieru , Wang Shaoyi , Wang Xing , Yin Shuai , Feng Jianhua , Wei Wenqing , Xu Xing , Chen Benzheng , Zhang Shisheng , Xu Zhongfeng , Hu Zhongmin , Li Fangfang , Xu Hao , Li Taotao , Li Yutian , Wang Yingying , Liu Lirong , Liu Wei , Fan Quanping , Chen Yong , Deng Zhigang , Qi Wei , Cui Bo , Zhou Weimin , Zhao Zongqing , Cao Zhurong , Gu Yuqiu , Cao Leifeng , Cheng Rui , Xue Quanxi , Hoffmann Dieter H. H. , Zhao Yongtao , Batani Dimitri 
Published: June 2022

The laboratory generation and diagnosis of uniform near-critical-density
(NCD) plasmas play critical roles in various studies and applications, such
as fusion science, high energy density physics, astrophysics as well as
relativistic electron beam generation. Here we successfully generated the
quasistatic NCD plasma sample by heating a low-density tri-cellulose acetate
(TCA) foam with the high-power-laser-driven hohlraum radiation. The
temperature of the hohlraum is determined to be 20 eV by analyzing the
spectra obtained with the transmission grating spectrometer. The
single-order diffraction grating was employed to eliminate the high-order
disturbance. The temperature of the heated foam is determined to be
T = 16.8 ± 1.1 eV by analyzing the
high-resolution spectra obtained with a flat-field grating spectrometer. The
electron density of the heated foam is about

N

e

=
4.0
±
0.3
×

10

20

cm

−
3

under the reasonable
assumption of constant mass density.
Abstract A04: NCI programs supporting technology development for population studies in digital age
Authors: Mechanic Leah E. , Carrick Danielle M. , Dickherber Tony , Klemm Juli ,   NCI Innovative Molecular Analysis Technologies (IMAT) Program, NCI Informatics Technology for Cancer Research (ITCR) Program
Published: June 2022

Abstract
Cancer is the result of a complex interplay of genetic, environmental, host, and societal factors operating over a prolonged time. The development of novel molecular technologies and informatics tools can facilitate a more comprehensive study of the risk factors contributing to the development of and outcomes from cancer in population studies. The National Cancer Institute (NCI) leads two programs in this area: the Innovative Molecular Analysis Technologies (IMAT) Program and the Informatics Technology for Cancer Research (ITCR) Program. IMAT supports the development, technical maturation, and dissemination of novel and potentially transformative next-generation technologies. ITCR program supports research-driven informatics technology development spanning all aspects of cancer research and stages of tool development, from algorithm development to prototyping, enhancement, and sustainment of these tools. The funding opportunities through these programs can support the development and application of new technologies for epidemiology research. For example, molecular technologies may address needs in areas such as exposure assessment, epigenetics, genomics, transcriptomics, imaging, and collection of biospecimens. Informatics technology needs may include genomic tools for data analysis, interpretation and visualization, annotation of genetic variants, supporting sharing of data, natural language processing of electronic health records (EHRs), managing cohort data collection, data harmonization, and extracting unstructured phenotype data from medical records. Importantly, the tools and resources that have been developed through these programs can be leveraged for use by epidemiology researchers. Learn more about the funding opportunities and technologies developed through these programs at https://imat.cancer.gov and https://itcr.cancer.gov.
Citation Format: Leah E. Mechanic, Danielle M. Carrick, Tony Dickherber, Juli Klemm, NCI Innovative Molecular Analysis Technologies (IMAT) Program, NCI Informatics Technology for Cancer Research (ITCR) Program. NCI programs supporting technology development for population studies in digital age [abstract]. In: Proceedings of the AACR Special Conference on Modernizing Population Sciences in the Digital Age; 2019 Feb 19-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(9 Suppl):Abstract nr A04.
Abstract A05: Fusobacterium nucleatum and clinicopathologic features of colorectal carcinoma: Results from the ColoCare Cohort
Authors: Mallea Patrick , Warby Christy A. , Stephens W. Zac , Gigic Biljana , Buhrke Kate , Lin Tengda , Boehm Juergen , Hardikar Sheetal , Santori Elisa K. , Schrotz-King Petra , Schneider Martin , Ulrich Alexis , Swanson Eric A. , Toriola Adetunji T. , Round June , Ulrich Cornelia M. , Holowatyj Andreana N. , Ose Jennifer 
Published: June 2022

Abstract
Background: Fusobacterium nucleatum (Fn) plays an active role in normal host physiology and has been associated with colorectal carcinogenesis. To date, the role of Fn in newly diagnosed colorectal cancer patients is unclear. This is the first study to evaluate associations between Fn abundance and clinicopathologic characteristics among neoadjuvant chemotherapy naïve colorectal cancer patients.
Methods: We used presurgery collected fecal stool samples from n=101 prospectively followed, newly diagnosed colorectal cancer patients from the ColoCare Cohort. Quantitative real-time polymerase chain reaction was used to amplify/detect Fn DNA in neoadjuvant chemotherapy-naïve patients, not using antibiotics for at least 1 month. Patients were classified into Fn-high (n=50) or Fn-low (n=51) groups based on median Fn Cycle thresholding (Ct) values (low≤16.72; high&gt;16.72) in fecal DNA. Multivariable regression was utilized to analyze associations between Fn and clinicopathologic characteristics such as tumor stage, tumor site, and tumor grade.
Results: We did not observe statistically significant differences in clinicopathologic or demographic characteristics by Fn abundance groups. Compared to the Fn-low patient group, Fn-high patients were 69% more likely to be diagnosed with stage III colorectal cancer (odds ratio [OR]=1.69, 95% confidence interval [CI] 1.56-15.93, P=0.0067), while there was no difference for stage I or II.
Conclusion: Human gut microbial composition, including Fusobacterium nucleatum abundance, may be linked to colorectal cancer progression.
Citation Format: Patrick Mallea, Christy A. Warby, W. Zac Stephens, Biljana Gigic, Kate Buhrke, Tengda Lin, Juergen Boehm, Sheetal Hardikar, Elisa K. Santori, Petra Schrotz-King, Martin Schneider, Alexis Ulrich, Eric A. Swanson, Adetunji T. Toriola, June Round, Cornelia M. Ulrich, Andreana N. Holowatyj, Jennifer Ose. Fusobacterium nucleatum and clinicopathologic features of colorectal carcinoma: Results from the ColoCare Cohort [abstract]. In: Proceedings of the AACR Special Conference on Modernizing Population Sciences in the Digital Age; 2019 Feb 19-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(9 Suppl):Abstract nr A05.
Abstract A10: Using large linked databases to understand cancer care access in northwestern Ontario, Canada
Authors: Febbraro Michela , Conlon Michael , Caswell Joseph , Laferierre Nicole 
Published: June 2022

Abstract
Residents in Ontario, Canada have universal public health insurance, and the Ontario Health Insurance Plan (OHIP) and almost all medically necessary services are captured in large linked databases. We leveraged these databases through the Ontario Cancer Data Linkage Project (cdLINK), to help us better understand access to cancer care for patients who reside in Northwestern Ontario, Canada. Northwestern Ontario is an area that covers a large geographic landmass (&gt;385,000 square kilometers) with low population density (0.4 people per square kilometer), and these factors often make the provision of health care challenging. This population-based retrospective study used the Ontario Cancer Registry (OCR) to define a cancer cohort of all residents of Northwestern Ontario who had a primary diagnosis of cancer, who were alive for at least 30 days, and who died from any cause between 2010 and 2016. Each index cancer case was linked with OHIP and Registered Persons Database (RPDB), and from these administrative sources we defined whether a consultation occurred, as well as selected sociodemographic factors associated with a consultation. We identified 2583 index cases (2010-2016). Of these, 78% (n=2007/2583) had receipt of a specialist consultation, defined as either a medical or radiation oncologist consultation. Factors associated with not receiving a specialist consultation included older age (p&lt;0.0001, Odds Ratio (OR) 0.29; 95% Confidence Interval (CI) 0.19-0.44) and rural residence (p&lt;0.0001, OR 0.48; 95% CI 0.48-0.72). Factors associated with receiving a specialist consultation included increased duration of disease (p&lt;0.0001, OR 1.32; 95% CI 1.19-1.46), a diagnosis of breast cancer (p&lt;0.0001, OR 2.51; 95% CI 1.43-4.42), and a diagnosis of lung cancer (p&lt;0.0001, OR 1.77; 95% CI 1.38-2.26). Linkage of administrative health records offers an important opportunity to understand access to care and factors associated with access to care. Future planned research will explore health services utilization and outcomes from cancer care in residents of Northwestern Ontario.
Citation Format: Michela Febbraro, Michael Conlon, Joseph Caswell, Nicole Laferierre. Using large linked databases to understand cancer care access in northwestern Ontario, Canada [abstract]. In: Proceedings of the AACR Special Conference on Modernizing Population Sciences in the Digital Age; 2019 Feb 19-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(9 Suppl):Abstract nr A10.