bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic value and safety of medical thoracoscopy under local anesthesia for unexplained diffuse interstitial lung disease: a pilot study
Authors: Zhang Lei , Xie Tian , Zhang Bingli , Fu Yihui , Ding Yipeng , Wu Haihong 
Published: April 2022

Abstract
Objective: We aimed to explore the safety and diagnostic value of medical thoracoscopic lung biopsy in patients with unexplained diffuse interstitial lung disease (ILD) in a single center pilot study. Method: We retrospectively analyzed clinical and pathological diagnostic data from 52 patients with diffuse ILD undergoing medical thoracoscopic lung biopsy. Results: Forty-four cases of diffuse ILD were confirmed pathologically, giving a diagnostic rate of 84.6%. Among these 44 patients, 11 patients were diagnosed with cancer, including 8 patients with lung adenocarcinoma, 3 patients with metastases; 2 from a gastrointestinal malignancy, and 1 from a granulosa cell tumor of the ovary. There were 17 cases of idiopathic interstitial pneumonia, including 9 cases of usual interstitial pneumonia (UIP), 4 cases of non-specific interstitial pneumonia (NSIP), 3 cases of cryptogenic organizing pneumonia (COP), and 1 case of acute interstitial pneumonia (AIP). There were 12 cases of rare interstitial pneumonias, which included 6 cases of pulmonary alveolar proteinosis, 1 case each of pulmonary Langerhans cell histiocytosis (LCH) and pulmonary lymphangiomyomatosis, 2 cases of nodular sarcoidosis, and 2 cases of chronic eosinophilic pneumonia. We recorded various complications, including bleeding, infection, and pneumothorax. A total of 28 patients (53.8%) experienced at least one of the above complications, but there were no deaths associated with biopsy. Conclusions: Medical thoracoscopic lung biopsy appears a safe and effective method for diagnosing diffuse ILD of unknown cause but further prospective studies, with larger numbers, including comparison with other established techniques are required.
Insect peptide COPA3 supplementation reduces the risk of heat stressed fibroblasts function
Authors: Siddiqui Sharif Hasan , Khan Mousumee , Park Jinryong , Lee Jeongeun , Choe Ho Sung , Kang Darae , Shim Kwanseob 
Published: April 2022

Abstract

Background
Heat stress inhibits cellular proliferation and differentiation through the production of reactive oxygen species. Under stress conditions, antioxidant drugs promote stable cellular function by reducing the stress level. We sought to demonstrate COPA3 supplementation stabilizes fibroblast proliferation and differentiation even under heat stress conditions.
Methods
In our study, fibroblasts were assigned to two different groups based on the temperature (control and heat stress) treatment. Each group was subdivided into two groups depending upon COPA3 treatment.
Results
Heat stress was observed to decrease the fibroblast viability and function and resulted in alterations in the fibroblast shape and cytoskeleton structure. In contrast, COPA3 stabilized the fibroblast viability, shape, and function. Moreover, heat stress and COPA3 were found to have contradictory actions with respect to energy production, which facilitates the stabilization of cellular functions by increasing the heat tolerance capacity. The gene expression levels of antioxidant and heat shock proteins were higher after heat stress. Additionally, heat stress promotes the mitogen-activated protein kinase/ extracellular signal-regulated kinase–nuclear factor erythroid 2-related factor 2 (MAPK/ERK-Nrf2).
Conclusions
COPA3 maintained the MAPK/ERK-Nrf2 gene expression that promote stable fibroblast proliferation, differentiation, and apoptosis. These findings suggest that COPA3 supplementation increases the heat tolerance capacity, viability, and functional activity of fibroblasts.
Dirac Equation Redux by Direct Quantization of the 4-Momentum Vector
Authors: Andoni S. 
Published: April 2022

Abstract
The Dirac equation (DE) is a cornerstone of quantum physics. We prove that direct quantization of the 4-momentum vector p with modulus equal to the rest energy m (c = 0) yields a coordinate-free and manifestly covariant equation. In coordinate representation, this is equivalent to DE with spacetime frame vectors xu replacing Dirac’s gamma-matrices. Recall that standard DE is not manifestly covariant. Adding an independent Hermitian vector x5 to the spacetime basis a allows accommodating the momentum operator in a real vector space with a complex structure arising alone from vectors and multivectors. The real vector space generated from the action of the Clifford or geometric product onto the quintet {x0, x1, x2, x3, x5} has dimension 32, the same as the equivalent real dimension for the space of Dirac matrices. x5 proves defining for the combined CPT symmetry, distinction of axial vs. polar vectors, left and right handed rotors & spinors, etc. Therefore, we name it reflector and {x0, x1, x2, x3, x5} a basis for spacetime-reflection (STR). The pentavector I = x05123 commutes with all elements of STR and depicts the pseudoscalar in STR. We develop the formalism by deriving all essential results from the novel STR DE: spin ½ magnetic angular momentum, conserved probability currents, symmetries and nonrelativistic approximation. In simple terms, we demonstrate how Dirac matrices are a redundant representation of spacetime-reflection frame vectors.
On clustering for cell phenotyping in multiplex immunohistochemistry (mIHC) and multiplexed ion beam imaging (MIBI) Data
Authors: Seal Souvik , Wrobel Julia , Johnson Amber M. , Nemenoff Raphael A. , Schenk Erin L. , Bitler Benjamin G. , Jordan Kimberly R. , Ghosh Debashis 
Published: April 2022

Abstract
Objective: Multiplex immunohistochemistry (mIHC) and multiplexed ion beam imaging (MIBI) images are usually phenotyped using a manual thresholding process. The thresholding is prone to biases, especially when examining multiple images with high cellularity. Results: Unsupervised cell phenotyping methods including PhenoGraph, flowMeans, and SamSPECTRAL, primarily used in flow cytometry data, often perform poorly or need elaborate tuning to perform well in the context of mIHC and MIBI data. We show that, instead, semi-supervised cell clustering using Random Forests, linear and quadratic discriminant analysis are superior. We test the performance of the methods on two mIHC datasets from the University of Colorado School of Medicine and a publicly available MIBI dataset. Each dataset contains numerous highly complex images.
Smartcity : Model Ketahanan Siber Untuk Usaha Kecil Dan Menengah
Authors: Putranti Ika Riswanti , Amaliyah Anita , Windiani Reni 
Published: April 2022

ABSTRACT This article placed an example of a cyber resilience model for smartcity in the context of smart-economy which was currently vulnerable to various cyber attacks. On the other hand SMEs were very limited in access to the development of networks and resources in building cyber resilience that ensured sustainability and increased the competitiveness of their businesses. Furthermore, this research identified the best practices of other countries, analyzed the readiness of legal instruments in Indonesia, identified the actors involved and analyzed the factors of obstacles in building a model of cyber resilience for SMEs. The result of this study was that security policy was a big theme with strategic principles in the security strategy of both actors and policies. This could help organizations such as MSMEs to identified, assessed and reduced threats in the cyber world.ABSTRAKArtikel ini meletakan contoh model ketahanan siber bagi smartcity dalam konteks smart-economy yang saat ini rentan terhadap berbagai serangan siber. Di sisi lain pelaku UKM sangat terbatas dalam akses pengembangan networking dan sumberdaya dalam membangun ketahanan siber yang menjamin keberlanjutan dan meningkatkan daya saing usahanya.Selanjutnya penelitian ini mengidentifikasi praktik terbaik negara-negara lain, menganalisis kesiapan perangkat hukum di Indonesia, mengidentifikasi aktor yang terlibat dan menganalisis faktor-faktor hambatan dalam membangun suatu model ketahanan siber bagi UKM.Hasil dalam pembahasan kajian ini adalah bahwasanya keamanan siber merupakan sebuah tema besar dengan prinsip-prinsip strategis dalam strategi keamanan baik berupa aktor maupun kebijakan. Hal ini dapat membantu organisasi seperti UMKM untuk mengidentifikasi, menilai, dan mengurangi ancaman dalam dunia siber.
Implementasi Sikap Bela Negara Guna Mewujudkan Ketahanan Pribadi (Studi di KB-TKIT Bintang Qur’an di Boyolali)
Authors: Rachmadany Halimah 
Published: April 2022

ABSTRACT The success of state defense education at an early age is crucial for the formation of personal resilience.Problems that appear (1) how is the implementation of state defense education for early childhood in kindergarten?;(2) what are the factors that support and hinder the educational process of defending the state in kindergarten?;dan (3) what is the effectiveness of state defense education to realize personal resilience?. The location of theresearch was carried out at TKIT Bintang Qur’an Boyolali using descriptive qualitative research methods withHuberman analysis techniques. The results showed that the implementation of state defense education for childernaged 5-6 years at TKIT Bintang Qur’an has been running systematically and realistically in accordance with theinstitution’s goals, namely to create a generation that faithful, pious, has noble character, has good character andhas personal resilience. In the implementation of state defense education, there are supporting and inhibiting factors,child development abilities, environment, facilities and infrastucture, exemplary attitudes of educators as well ascollaboration programs with parents and the learning strategies used. The effectiveness of state defense educationcan be seen from the characteer of the students at TKIT Bintang Qur’an who have a sense of love for the homelandas evidences by implementing behavior in accordanc with Pancasila, childern are able to sing national and regionalsongs, like various cultures that exist in Indonesia. Has empathy and tolerance, is accustomed to doing activitiescooperatively and mutual cooperation, has self confidence and the spirit of a leade
Prevención de depredación de yaguareté (Panthera onca) a ganado vacuno mediante cercas electrificadas en Misiones, Argentina
Authors: Lodeiro-Ocampo Nicolás , G. Gantchoff Mariela , A. Nigro Norberto , Palaia Julián Y. , Gnatiuk Daniel G. 
Published: April 2022

Resumen
El yaguareté está en peligro crítico de extinción en Argentina. Una de las principales causas de la disminución de sus poblaciones es su cacería como represalia de los ganaderos ante eventos de depredación. En el presente estudio reportamos los resultados de la implementación de un corral electrificado anti-depredación, durante cuatro años, en un potrero ganadero que colinda con un área selvática en Argentina. Describimos el sistema del alambrado eléctrico, y comparamos dos potreros adyacentes, con y sin corrales electrificados. El alambrado fue 100% efectivo en prevenir ataques de yaguareté. Una combinación de corrales electrificados con otras estrategias como el apoyo logístico y monetario para los ganaderos, y la difusión de potenciales consecuencias legales de la cacería de yaguaretés, han facilitado la convivencia entre estos felinos y la ganadería. Esto ha sido fundamental para facilitar las acciones de conservación con actividades económicas.
Palabras clave: carnívoros, conflicto, convivencia, depredación, felinos, ganaderos, mitigación, yaguareté.
MENINGKATKAN AKTIVITAS DAN HASIL BELAJAR IPA MELALUI MODEL DISCOVERY LEARNING SISWA KELAS IV SD NEGERI 1 SAMALANGA
Authors: Misrina Misrina 
Published: April 2022

The learning process in science learning focuses on providing direct learning experiences to students so that they are able to develop competencies in order to understand the natural surroundings scientifically. Therefore, learning process an important role in improving student learning outcomes, so that student competencies develop optimally. The research aims to improve the activities and learning outcomes of science through discovery learning models of grade IV students atSD Negeri 1 Samalanga. Subjects of this research were 26 students. This research is a classroom action research, which is carried out in two cycles. The results of the research are in the form of activities and student learning outcomes. Based on observation data and final test results in cycle 1, the data obtained for student learning activities with a percentage of 78.18% while the completeness of learning outcomes is only 65.38%. This means that both activities and student learning outcomes in cycle 1 have not reached completeness. Therefore, the researcher continued the research to cycle 2. The acquisition of activity data and learning outcomes in cycle 2 increased where the percentage of mastery learning activities increased to 92.72% while the percentage of learning outcomes reached 88.46%. Thus there is an increase in science learning activities and outcomes through the discovery learning model of grade IV students at SD Negeri 1 Samalanga
IL-4 Serum Level Estimation in Myeloproliferative Neoplasm Patients
Authors: Abdullah Ahmed Rushdi 
Published: April 2022

Back Ground: Myeloproliferative neoplasm (MPN) is a long-term blood disease that has an excess production of mature hematopoietic pluripotent stem cells in the bone marrow. In the early fifties, W. Dameshek structured the Myeloproliferative disorders that are at present the World Health Organization (WHO) changed it to Myeloproliferative Neoplasms (MPNs). According to the Iraqi cancer registry, Chronic Myeloproliferative disorders in the male is 0.62% and the incidence rate is 0.36, in female Chronic Myeloproliferative disorders (45 case) is 0.31% and the incidence rate is 0.24. The JAK2-V617F genetic mutation is approximately seventy percent of the Myeloproliferative Neoplasm cases. Interleukin-4 plasma and serum levels are significantly increased in MPNs different types.
Objectives: The goal of this study is to estimate the IL-4 serum levels in the JAK2-V617F negative and positive mutation in the Iraqi MPNs patients.
Materials and Methods: Total of (60) patients screened by cohort prospective study of having MPN who are patients presented to the National Center of Hematology / Al-Mustansiriyah University. Depending on the JAK2-V617F genetic mutation we classified our MPNs cases into 3 groups: JAK2-V617F negative (N: 20), JAK2-V617F positive (N: 40) and control group (10). Blood sample (5) ml was obtained from each individual in each group, by venipuncture using disposable syringes for IL-4 serum estimation by Enzyme Linked ImmunoSorbent Assay (ELISA) technique.
Results: A clear indication of significant differences was observed between IL-4 serum level in JAK2-V617F negative samples and control samples (P < 0.05).
Conclusion: The IL-4 serum level is high in MPNs patients, which is one of the immune evading mechanisms of the cancerous acting to imbalance the Th1/Th2 ratio and enhancing the anti-apoptotic activity inside those cells.
Using Adsorption as Means to Treat Water Pollution
Authors: Al-Muttair Ali K. , Al Easawi Nada A. R. , Mustafa Sama A. 
Published: April 2022

Background: Water is the source of life form and this crucial source is continuously being polluted through variety of human activities and from natural sources. Many methods have been used to treat water from these pollutants with different degrees of success; one of the most promising techniques is adsorption. Adsorption have been used extensively with variety of adsorbents range from the expensive activated carbon to cheap plant waste.
Aim of study: This review provides a scope on the adsorption process and the factors affect the adsorption, types of adoption, isotherm studies and models as well as some examples on the past studies conducted to eliminate various types of contaminants such as chemical dyes, heavy metals and crude oil and other aromatic compounds.
KETERKAITAN KONSUMSI PRODUK BERLABEL HALAL DENGAN KETAATAN BERAGAMA
Authors: Hatoli Hatoli 
Published: April 2022

Halal products are a moral and material necessity. For Muslims, morally the product does not violate the rules of halal and haram in carrying out religious orders. Materially, this halal product is universal not only for Muslim societies, but also for all societies regardless of differences given that halal products aim to provide comfort, safety and legal certainty in consuming them. The Indonesian Ulema Council (MUI) is the agency authorized to research and provide fatwa on the halal illegality of a product so that it makes consumers feel safe and comfortable using the product without worrying about fulfilling their religious orders. Then what about products without the halal label, given the halal certification that is voluntary. Are Muslim consumers who consume these products included in the category of disobeying religious orders? And what is the position of this in view of Islamic teachings and law that they believe in?
This paper would like to describe the correlation of halal labeled products with one's obedience in religion using qualitative research methods that are descriptive in nature, and the type of approach used is the empirical sociological legal approach, which is guided by regulations, books or legal literature and materials that have a relationship with the problem and discussion in this paper. Halal certification of a product issued by MUI does not mean forbidding other products without a halal label but aims to provide legal certainty and quality of a product and provide various benefits that can be obtained if the manufacturer provides halal guarantees on its products. But there is a more explicit need behind it, namely the spiritual need that is trying to be lived in, namely obedience in fulfilling religious orders.
Transcatheter aortic valve implantation in frail patient
Authors: Santos Llivisaca Lisseth Yessenia , Mesa-Cano Isabel Cristina , Ramírez-Coronel Andrés Alexis , Minchala-Urgilés Rosa Elvira 
Published: April 2022

One of the most common diseases is aortic sternosis, which is described as a reduction in the diameter of the aortic valve, this disease is characterized by a narrow passage of blood to the heart resulting in high mortality in patients with cardiac problems, particularly in the elderly. The aim of this research is to know the incidence of transcatheter aortic valve implantation in frail patients, through a literature review. This research has a qualitative approach, with a systematic review of the literature. It was descriptive, analyzing the characteristics of the society and with a cross-sectional cohort. As main result we have that the patient who has followed this procedure has had favorable results, having greater benefits such as a reduced intervention time and a more effective recovery, this treatment is so well accepted that it is currently being applied to other patients. Thus, we can conclude that the use of TAVI in the fragile patient is advisable as long as there is a proper assessment by the physician that takes into consideration the patient's condition and the prosthesis to be used.
La cultura organizacional y su incidencia en el desempeño laboral del personal administrativo de la Casa de la Cultura Benjamín Carrión Núcleo Los Ríos
Authors: Loor Caicedo Dorys Ildelira , Morejón Del Rosario Nory Irene , Mestanza Segura Lorena Del Rocío , Mestanza Segura Pedro Alexander 
Published: April 2022

La Casa de la Cultura Benjamín Carrión Núcleo Los Ríos es una Institución Pública, que promueve la cultura y el arte, pues las actividades que se desarrollan en la Institución, dependen de los valores, principios normas y culturas que se desarrollan en la misma, así como también es muy importante su talento humano y su desempeño laboral, el mismo que debe estar incentivado, motivado y tener sentido de pertinencia para lograr las metas que se propone esta loable Institución. El presente Trabajo de Investigación se basa en proponer estrategias de cultura organizacional y convivencia que mejoren el desempeño laboral del personal Administrativo de la Casa de la Cultura Benjamín Carrión Núcleo Los Ríos, investigación que ha sido desarrollada gracias al apoyo de su director y personal administrativo; pues con esto podemos lograr fomentar los valores mejorar las relaciones interpersonales, sentido de pertinencia, actitudes negativas, conflicto entre compañeros y falta de comunicación. La Investigación que se realizó en la Casa de la Cultura Benjamín Carrión Núcleo Los Ríos, nos manifestó que el tipo de Cultura organizacional que profesa la Institución es jerárquica, que es necesario un Manual de Cultura Organizacional, convivencia y aplicar los 7 hábitos de la gente altamente efectiva, para mejorar el desempeño laboral de sus colaboradores, que no cuenta con un ambiente adecuado, con herramientas necesarias e idóneas para el desarrollo de sus actividades, que los valores que los identifica es el respeto, sentido de pertinencia, trabajo en equipo, y seguridad, que los aspectos negativos a cambiar dentro de ésta Institución, sería el conflicto entre compañeros, falta de comunicación, actitudes negativas y falta de incentivos. Por consiguiente, con la propuesta realizada en ésta investigación del diseño del manual de cultura organizacional, nos permitió fomentar actitudes y aptitudes, valores personales e institucionales, para el mejoramiento del desempeño personal administrativo de la Casa de la Cultura Benjamín Carrión Núcleo Los Ríos.
Diseño de un prototipo de vivienda social, basado en lineamientos arquitectónicos
Authors: Ponce Zorrilla Jorge Leonardo , Cedeño Anchundia Adil Fernando , Alcívar Moreira William Stalin 
Published: April 2022

El déficit habitacional que presenta América Latina, es uno de los problemas latentes en las ciudades, la falta del uso de normativas genera el deterioro de la imagen urbana. El presente artículo está orientado como guía para estimular sectores que presenten un crecimiento desordenado y fragmentado mediante la propuesta del diseño de un prototipo de vivienda de interés social, basado en lineamientos arquitectónicos que permitan mejorar las condiciones físicas y espaciales de la vivienda, que adopte nuevos enfoques de desarrollo urbano y permita la consolidación de los territorios para generar equilibrio social. En la ciudadela Alberto Heredia del cantón Jipijapa, provincia de Manabí, a través de las técnicas de observación y análisis, se exhibió la carencia de identidad urbana, identificando los asentamientos esporádicos que han causado el deterioro del paisaje urbano. La investigación se realizó mediante el levantamiento fotográfico que permitió identificar la problemática existente en el sector, a su vez se realizaron estudios de campo para obtener la información requerida. Conociendo los factores socio-económicos y delimitada el área de estudio, se elaboró un prototipo de vivienda social considerando espacios, zonificación, conectividad, confort, ventilación, iluminación y entorno con el medio, fundado en la aplicación de teorías y modelos de crecimiento urbano que han sido empleado en otros países, para disminuir la precariedad de la vivienda, mediante el uso y regulación de políticas públicas sobre el ordenamiento y uso del suelo en la zona de estudio.