bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood Lead and High-Density Lipoprotein Concentrations in Relation to Human Blood Pressure: A Cross Sectional Study
Authors: Hu Biao , He Pei-yao , Zhong Nan-nan , Gao Zi-min , Guo Jiang-long , Feng Jun-tao , Huang Chu-qin , Yang Jun-bo , Sun Dong-lin 
Published: June 2022

BackgroundWhile the relationship between blood pressure and blood lead has been studied more extensively, the effect of high-density lipoprotein (HDL) concentration on this relationship remains uncertain. Therefore, this study aimed to determine the effect of HDL concentration on the relationship between blood lead and blood pressure.MethodsThe research used cross-sectional data from the 2005 to 2014 National Health and Nutrition Examination Survey (NHANES), which included 16,451 participants aged 20–60 years. Multivariable linear regression was used to evaluate the correlation among blood lead, systolic blood pressure (SBP), and diastolic blood pressure (DBP). HDL concentration was determined by low HDL concentration (≤ 49 mg/dl) and high HDL concentration (&gt;49 mg/dl) stratified. The effect of HDL concentration was assessed by an interaction test between blood lead and SBP in multivariable linear regression.ResultsIn this cross-sectional research, we identified a positive correlation between blood lead and SBP, but not DBP. The relationship between blood lead and SBP was different in the group with low and high HDL concentrations (β: 0.21 95% Cl:−0.05-0.46 vs. β:0.47 95% Cl: 0.15-0.79). In addition, high HDL significantly altered the positive correlation between blood lead and SBP (P-value of interaction &lt; 0.001).ConclusionThe study suggests an interaction between HDL and blood lead in elevating SBP, which may have important clinical implications.
Maternal Perceptions About Sensory Interventions in the Neonatal Intensive Care Unit: An Exploratory Qualitative Study
Authors: Lisle Julia , Buma Kylie , Smith Joan , Richter Marinthea , Satpute Prutha , Pineda Roberta 
Published: June 2022

BackgroundMothers play an important role in providing positive sensory experiences to their infants during NICU hospitalization. However, little is known regarding maternal perceptions about sensory-based interventions in the NICU. Further, understanding maternal perceptions was an important part of the process during development of the Supporting and Enhancing NICU Sensory Experiences (SENSE) program.MethodsTwenty mothers of very preterm infants were interviewed after NICU discharge and asked open-ended questions about sensory-based interventions they performed in the NICU and probed about their perceptions related to the development of a sensory-based guideline and the use of volunteers to provide sensory-based interventions when unable to be present in the NICU. Interviews were transcribed and uploaded into NVivoV.12 for content analysis.ResultsMothers reported that kangaroo care was a common sensory intervention they performed in the NICU. Of the 18 mothers who commented on the development of a sensory-based guideline, 17 (94%) said they would be accepting of one. Among 19 mothers, 18 (95%) supported volunteers conducting sensory-based interventions in their absence. Identified themes included: 1) Perceptions about development of a sensory-based guideline, 2) Perceptions of interactions with healthcare providers, 3) Maternal participation in sensory interventions, 4) Maternal experience, and 5) Emotions from mothers.ConclusionMaternal perceptions regarding the development of a sensory-based guideline were favorable, and the SENSE program has since been finalized after incorporating important insights learned from stakeholders in this study. Mothers' perceptions were tied to their NICU experiences, which elicited strong emotions. These findings highlight important considerations when developing family-centered interventions.
Point-of-Care Gastric Ultrasound Confirms the Inaccuracy of Gastric Residual Volume Measurement by Aspiration in Critically Ill Children: GastriPed Study
Authors: Valla Frederic V. , Cercueil Eloise , Morice Claire , Tume Lyvonne N. , Bouvet Lionel 
Published: June 2022

IntroductionNo consensus exists on how to define enteral nutrition tolerance in critically ill children, and the relevance of gastric residual volume (GRV) is currently debated. The use of point-of-care ultrasound (POCUS) is increasing among pediatric intensivists, and gastric POCUS may offer a new bedside tool to assess feeding tolerance and pre-procedural status of the stomach content.Materials and MethodsA prospective observational study was conducted in a tertiary pediatric intensive care unit. Children on mechanical ventilation and enteral nutrition were included. Gastric POCUS was performed to assess gastric contents (empty, full of liquids or solids), and gastric volume was calculated as per the Spencer formula. Then, GRV was aspirated and measured. The second set of gastric POCUS measurements was performed, similarly to the first one performed prior to GRV measurement. The ability of GRV measurement to empty the stomach was compared to POCUS findings. Both GRV and POCUS gastric volumes were compared with any clinical signs of enteral feeding intolerance (vomiting).ResultsData from 64 children were analyzed. Gastric volumes were decreased between the POCUS measurements performed pre- and post-GRV aspiration [full stomach, n = 59 (92.2%) decreased to n = 46 (71.9%), p =0.001; gastric volume: 3.18 (2.40–4.60) ml/kg decreased to 2.65 (1.57–3.57), p &lt; 0.001]. However, the stomach was not empty after GRV aspiration in 46/64 (71.9%) of the children. There was no association between signs of enteral feeding intolerance and the GRV obtained, nor with gastric volume measured with POCUS.DiscussionGastric residual volume aspiration failed to empty the stomach and appeared unreliable as a measure of gastric emptiness. Gastric POCUS needs further evaluation to confirm its role.
Urinary Neutrophil Gelatinase-Associated Lipocalin Can Predict the Efficacy of Volume Expansion Therapy in Patients With Hepatitis B Cirrhosis and AKI
Authors: Duan Zhonghui , Jiang Minjie , Huang Xiaojie , Liu Haixia , Yu Hongwei , Meng Qinghua 
Published: June 2022

Backgrounds: Kidney biomarkers in urine appear to be useful in differential diagnosis between acute tubular necrosis and other types of acute kidney injury (AKI) in cirrhosis. In clinical practice, prerenal azotemia (PRA) is often distinguished from other types of AKI by volume expansion therapy. The aim of the current study was to investigate the accuracy of urinary biomarkers in the differential diagnosis between PRA and other types of AKI.Methods: A total of 65 patients with hepatitis B cirrhosis were prospectively included and divided into AKI and non-AKI groups. Patients with hepatitis B cirrhosis and AKI discontinue diuretics, vasodilators, and nephrotoxic drugs and give volume expansion therapy. The efficacy was judged after 48 h of treatment. Urinary biomarkers were measured at the time of diagnosis of AKI and 48 h after volume expansion therapy. Univariate and multivariate analyses were used to identify independent risk factors for nonresponse to volume expansion therapy.Results: Of the 65 patients, 49 patients with newly diagnosed AKI were screened in the study, and 16 hospitalized patients with hepatitis B cirrhosis without AKI at the same period were screened as the control group. In patients with cirrhosis and AKI, 29 (59.18%) patients were in the response group and 20 (40.81%) patients were in the nonresponse group. The mortality rate in the nonresponse group was significantly higher than that in the response group (75% vs. 13.8% p &lt; 0.001). After logistic regression analysis, urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum creatinine (SCr) at diagnosis of AKI showed significant association with nonresponse to volume expansion therapy. The cutoff values for SCr and urinary NGAL were 128.50 µmol/L and 90.75 ng/ml, respectively. The area under the receiver operating curve (AUC) for SCr and urinary NGAL was 0.815 and 0.831.Conclusion: Elevated urinary NGAL can reflect the degree of kidney injury and is an independent risk factor for nonresponse to volume expansion therapy in patients with hepatitis B cirrhosis and AKI.
Case Report: Bosentan and Sildenafil Exposure in Human Milk - A Contribution From the ConcePTION Project
Authors: Nauwelaerts Nina , Ceulemans Michael , Deferm Neel , Eerdekens An , Lammens Bart , Armoudjian Yeghig , Van Calsteren Kristel , Allegaert Karel , de Vries Loes , Annaert Pieter , Smits Anne 
Published: June 2022

Introduction: Quantitative information on disposition of maternal medicines in human milk remains a major knowledge gap. This case report presents the clinical and pharmacokinetic data of a single mother-infant pair exposed to bosentan and sildenafil for the treatment of pulmonary arterial hypertension (PAH) during lactation.Case presentation: A 43-year old mother was treated with sildenafil (20 mg, 3x/day) and bosentan (125 mg, 2x/day) for PAH. Her 21-months old infant received breastfeeding in combination with adequate complementary foods. Milk samples were collected over 24 h, at day 637 and 651 after delivery. The observed average steady-state concentrations of sildenafil (2.84 μg/L) and bosentan (49.0 μg/L) in human milk were low. The Daily Infant Dosage ingested by the nursing infant through human milk was 0.02 μg/kg/day for sildenafil and 0.29 μg/kg/day for bosentan at day 637, and 0.03 μg/kg/day and 0.60 μg/kg/day at day 651. The Relative Infant Dose calculated for an exclusively breastfed infant with an estimated milk intake of 150 ml/kg/day, was 0.06% for sildenafil and 0.24% for bosentan. General health outcome of the infant, reported by the mother, was uneventful until the sampling days.Conclusion: Low medicine concentrations were found in human milk expressed 21 months after delivery after maternal intake of 20 mg sildenafil three times daily and 125 mg bosentan twice daily. General health of the nursing infant until sampling was reported as optimal by the mother.
Grevillea robusta Delayed the Progression of Experimentally Induced Hepatic Fibrosis and Cirrhosis in Wistar Rats by Attenuating the Expression of Smooth Muscle Actin, Collagen, and TGF-β
Authors: Hameed Saaid , Ur Rehman Atta , Massey Shazma , Syed Nawazish-i-Husain , Anwar Fareeha , Ahmed Dildar , Ahmad Sarfraz 
Published: June 2022

The chronic damage to the liver causes fibrosis, especially when different proteins are accumulated in the liver, which is the basic characteristic of chronic liver damage. The excessive accumulation of the matrix protein such as collagen causes liver fibrosis. Liver fibrosis leads to cirrhosis, liver failure, and portal vein hypertension. Plants having antioxidants, free radical scavenging activities, and anti-inflammatory constituents are believed to be hepatoprotective in nature. Grevillea robusta (GR) is native to the subtropical environment. Its in vitro antioxidant, cytotoxic, and free radical scavenging activities are known, while the effect on liver fibrosis and cirrhosis remains elusive. The aim of this study was to evaluate the hepatoprotective and antifibrotic effects of Grevillea robusta plant. GR leaf extract (GREE) was prepared from the hydroethanolic extract (70%). Polyphenol and flavonoid contents and the in vitro antioxidant activity of the extract were determined. In vivo hepatitis was induced in Wistar rats by continual IP injections of CCl4. GREE was administered by oral gavage at a dose of 100, 300, and 500 mg/kg of body weight once daily for 4 weeks. Variations in rat’s body weight, liver-to-body weight ratio, serum alanine aminotransferases, gamma-glutamyltransferase, liver histology, and cellular markers of liver fibrosis were evaluated. Serum levels of alanine aminotransferase (ALT) (p &lt; 0.05) and gamma-glutamyltransferase (γ-GT) (p &lt; 0.001) were decreased in the treatment group compared with the disease control group. RBC count was increased (p &lt; 0.001) in the treatment group compared with the disease control group. The expression of alpha-SMA was downregulated to 40% (p &lt; 0.05) and that of collagen was decreased by 9% (p &lt; 0.05) compared with the disease control group. Extracellular matrix deposition and necrotic areas were also decreased as compared to the disease control group. It can be concluded that GR possesses hepatoprotective action by virtue of antioxidant constituents and delays the progression of liver cirrhosis by suppressing the activation of extracellular matrix–producing cells in the liver.
Physiological Responses of the Firefly Pyrocoelia analis (Coleoptera: Lampyridae) to an Environmental Residue From Chemical Pesticide Imidacloprid
Authors: Wang Yi-zhe , Cao Cheng-quan , Wang Dun 
Published: June 2022

Imidacloprid, a neonicotinoid insecticide, is widely applied to control insect pests across a broad spectrum. Though the impact of residues from this chemical pesticide on non-target organisms in the field has been reported, it was not well characterized across a wide range of ecosystems, especially for some species considered as environmental indicators that live in forests. The effects of sublethal dose of imidacloprid on firefly, Pyrocoelia analis, were analyzed physiologically and biochemically in this study to better understand the impact of chemical pesticide application on environmental indicators such as fireflies. After imidacloprid treatment, the midgut tissues of the larva presented an abnormal morphology featured as atrophy of fat body cells, shrinking cells, and the destruction of a midgut structure. The activities of antioxidant enzymes, superoxide dismutase, catalase, and peroxidase were noticeably increased during early exposure to sublethal imidacloprid and then decreased at later stages. The malondialdehyde content significantly increased after 12 h of exposure to imidacloprid compared with the control. Similarly, the enzyme activities of polyphenol oxidase and acetylcholinesterase were increased after the imidacloprid treatment and then decreased at the later stage. In summary, a sublethal dose of imidacloprid caused destructive change in the tissue structure, and this damage was followed by an excessive reactive oxygen species that could not be eliminated by antioxidant enzymes. Our results indicated that the residues of imidacloprid might cause severe toxicity to non-target insects in the environment even far away from the agro-ecosystem where the chemicals were applied.
Validation of the 33-Item Hypomania Checklist-External Assessment in Screening Adolescents for Bipolar Disorder
Authors: Chen Xu , Cai Hong , Bai Wei , Sha Sha , Cheung Teris , Ungvari Gabor S. , Feng Yuan , Xiang Yu-Tao , Angst Jules 
Published: June 2022

BackgroundBipolar disorder (BD) is often misdiagnosed, leading to poor treatment outcomes. Thus, accurate assessment of BD is of great importance, including in BD adolescents. The aim of the study was to explore the psychometric properties of the 33-item Hypomania Checklist-External Assessment (HCL-33-EA) in depressed adolescents.MethodsThe study was conducted between March and November 2020 in Beijing, China. Depressed adolescents aged between 13 and 17 years (N = 260) with BD (N = 147) or major depressive disorder (MDD) (N = 113) diagnosed according to the International Classification of Diseases, Tenth Revision (ICD-10) were recruited. Patients’ hypomanic symptoms were assessed by their carers using the HCL-33-EA.ResultsThe HCL-33-EA showed high internal consistency (Cronbach’s alpha = 0.82) with two factorial dimensions. The Receiver Operating Characteristic (ROC) curve analysis revealed an area under the ROC curve (AUC) value of 0.61 (95% confidence interval (CI): 0.54–0.67). The optimal cut-off score of 7 generated the best combination of sensitivity (0.81) and specificity (0.37) for discriminating between adolescents with BD and MDD.ConclusionThe HCL-33-EA, with a two-factor structure, seems to be a useful tool for screening for BD in depressed adolescents. However, the high sensitivity and low specificity of the HCL-33-EA at the optimal cut-off value of 7 indicate that the HCL-33-EA needs to be further refined for young patients.
Influencing Factors of Students Aged 10–20 Non-participating in Home Physical Exercise During the COVID-19 Isolation Policy Period: A Cross-Sectional Study From China
Authors: Luo Lin , Zeng Xiaojin , Wu Yan , An Fei , Huang Jiahong , Yang Hao , Jiang Quanning , Ou Qiang , Du Jianjun , Song Naiqing 
Published: June 2022

BackgroundA number of public health measures are required during the COVID-19 pandemic. To stop the spread of COVID-19, the Chinese government has adopted isolation policies, including closing non-essential businesses, public transportation and schools, moving students' face-to-face learning to online, and recommending the cancellation of all non-essential activities and outdoor activities. However, while this isolation strategy has reduced human-to-human transmission of COVID-19, it has led to dramatic changes in students' daily lives and learning styles, including reduced physical activity and increased sedentary time. Considering the potentially harmful effects of physical inactivity, this study hoped to explore the incidence and influencing factors of non-participation in home physical exercise among Chinese students aged 10–20 during the implementation of the COVID-19 isolation policy.MethodsThrough an online questionnaire platform, this study created an open-ended questionnaire (from March 1, 2020 to March 10, 2020) and distributed it to students in areas where isolation policies were enforced. The questionnaire was initially distributed by 10 recruited volunteers, and then the questionnaire was voluntarily forwarded and shared by the subjects or others, in a “snowball” way, to expand distribution. Finally, the survey data of 4,532 Chinese students aged 10–20 were collected. The incidence of respondents non-participating in home physical activity was determined using univariate analysis. Using odds ratios and 95% confidence intervals of a multivariate binary logistic regression model, factors influencing non-participation in home physical exercise were estimated.ResultsAmong the sample students, the incidence rate of non-participating in home physical exercise was 25.86% (24.06–27.15%). Exercise intentions, exercise habits, self-assessed health, beliefs in physical health, family exercise, family exercise recommendations, home exercise conditions, school exercise guidance, and health education programs had a negative impact on students non-participating in home physical exercise. Academic performance and electronic product use had a positive effect on non-participating in home physical exercise.ConclusionsA variety of forward leaning factors, enabling factors and demand factors have affected the occurrence of students” non-participating in home physical exercise. Future health isolation policies should take into account these influencing factors to reduce the occurrence of students” non-participating in home physical exercise and to promote students' independent participation in physical exercise.
A Latent Class Analysis of Student Eye Care Behavior: Evidence From a Sample of 6–17 Years Old in China
Authors: Li Mengying , Wang Wenjing , Zhu Boya , Tan Xiaodong 
Published: June 2022

PurposeTo understand the latent classes and distribution of an adolescent eye care behavior, and to provide a basis for the formulation of appropriate adolescent vision health management interventions.MethodsInformation on eye behavior and eye health of primary and secondary school students in Wuhan was collected by multistage stratified cluster sampling. The latent class analysis (LCA) method was used to analyze the students' eye care behavior, and the latent class model (LCM) was built.ResultsA total of 6,130 students were enrolled in this study, of which 53.56% were males, aged from 6 to 17 years old, with an average age of 10.33 ± 2.60. The latent class results classified the adolescents' eye care behaviors into bad behaviors, moderate behaviors, and healthy behaviors. The model fitting results were as follows: Akaike Information Criterion (AIC) was 36,698.216, Bayesian Information Criterion (BIC) was 36,906.565, Adjusted Bayesian Information Criterion (aBIC) was 36,808.056, and entropy was 0.838.Compared with the healthy behaviors class, the bad behaviors class was more prevalent in high schools (p = 0.003), non-demonstration schools (p = 0.001), and most of this group had astigmatism (p = 0.002). The moderate behaviors class predominately consisted of females (p = 0.001), 15–17 years old (p = 0.005, 6~8 years old as the reference), from non-demonstration schools (p &lt; 0.001), and most had myopia (p = 0.009).ConclusionThere were differences in basic demographic characteristics, visual acuity development level, and family visual environment among different classes. In the management and intervention of an adolescent vision health, we should continue to promote the visual health management of adolescents based on visual monitoring and realize the early intervention and guidance of individuals in bad behaviors class.
The Short-Term Efficacy of Bikini Incision and Traditional Incision in Total Hip Replacement for Elderly Patients via the Direct Anterior Approach
Authors: Zhang Qingsong , Liu Bo , Zhao Binghao 
Published: June 2022

BackgroundThe study aimed to explore the short-term clinical efficacy of bikini incision and traditional incision in total hip replacement via the direct anterior approach.MethodsThe study enrolled 94 patients who underwent total hip replacement using the direct anterior approach between March 2018 and April 2020. They were assigned to the study group and the control group with 47 patients in each group using the random number table method. They received traditional incision and bikini incision, respectively. The operative time, intraoperative estimated blood loss, postoperative pain, length of hospital stay, incision healing, postoperative Harris score, and occurrences of complications were compared between the two groups.ResultsThere was no statistically significant difference in operative time, incision length, and intraoperative estimated blood loss between the two groups (P &gt; 0.05). The length of hospital stay was shorter in the study group than that of the control group, and the difference was statistically significant (P &lt; 0.05). There was no statistically significant difference in pain severity between the two groups (P &gt; 0.05). No incision infection occurred in either group. The study group had small scar areas and scar scores than the control group (P &lt; 0.05). There was no statistically significant difference in Harris scores between the two groups at three and six months postoperatively (P &gt; 0.05). The rate of lateral femoral cutaneous nerve injury was lower in the study group than that of the control group, and the difference was statistically significant (P &lt; 0.05).ConclusionBikini incision in total hip replacement via the direct anterior approach can shorten the length of hospital stay, promote incision healing, lower the incidence of complications, improve the prognosis, and promote recovery of patients, and it is worthy of being promoted for wide clinical use.