bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large‐Scale Targeted Sequencing Study of Ischemic Stroke in the Han Chinese Population
Authors: Shi Mengyao , Kelly Tanika N. , Zhu Zhengbao , Li Changwei , Shen Chong , Sun Yingxian , Wang Aili , Shan Guangliang , Bu Xiaoqing , Guo Daoxia , Zhao Jingbo , Xu Tan , Peng Hao , Xu Tian , Zhong Chongke , Sun Xiao , Chen Jing , Zhang Yonghong , He Jiang 
Published: October 2022

Background
Ischemic stroke is likely caused by interactions of multiple genes and environmental determinants. However, large‐scale sequencing studies to discern functional genetic variants and their interactions with clinical and lifestyle risk factors on ischemic stroke are limited.

Methods and Results

We sequenced functional regions of 740 previously identified genes associated with atherosclerotic disease among 999 ischemic stroke cases and 1001 controls of Chinese ancestry. Multiple logistic regression models were used to examine the associations between variants and ischemic stroke and test interactions between variants and clinical and lifestyle risk factors. Functional variants achieving suggestive significance were replicated in an independent sample of 4724 ischemic stroke cases and 5029 controls. Driven by variant main effects, each minor allele of the correlated rs174535, rs174545, and rs3834458 variants at
MYRF‐FADS1‐FADS2
conferred an average 0.83‐fold (95% CI, 0.78–0.88) decreased odds of stroke. Significant main effects of
MTHFR
rs1801133 missense variant were also observed, with each copy of the A allele associated with a 1.20‐fold (95% CI, 1.13–1.27) higher odds of ischemic stroke. The functional
ALDH2
rs671 variant was identified in interaction analyses with alcohol drinking (
Meta‐P
=3.39×10
−17
). Each minor allele conferred a 0.54‐fold (95% CI, 0.45–0.64) decreased odds of stroke among drinkers and a 0.89‐fold (95% CI, 0.83–0.97) decreased odds among nondrinkers.

Conclusions

Significant associations at
MYRF‐FADS1‐FADS2
indicate that genetically elevated polyunsaturated fatty acids may decrease ischemic stroke risk in East Asians. Significant associations at
MTHFR
and
ALDH2
robustly confirm deleterious effects of genetically elevated homocysteine and alcohol intake, respectively, on ischemic stroke.
Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study)
Authors: Kim Seong Hwan , Shin Chol , Kim Sunwon , Kim Jin‐Seok , Lim Sang Yup , Seo Hyeong‐Seok , Lim Hong Euy , Sung Ki‐Chul , Cho Goo‐Yeong , Lee Seung Ku , Kim Yong‐Hyun 
Published: October 2022

Background
Apart from nondippers’ impact on cardiovascular events, the prevalence of isolated nocturnal hypertension (INH) and its consequences on both the heart and brain were not clearly investigated in the general population.

Methods and Results

The participants underwent ambulatory blood pressure monitoring evaluations for arterial stiffness, echocardiography, and brain magnetic resonance imaging. They were grouped into normotension, INH, and overt diurnal hypertension, based on ambulatory blood pressure monitoring and history of antihypertensive treatment. White matter hyperintensity, arterial stiffness, and echocardiographic parameters were compared. Of the 1734 participants, there were 475 (27.4%) subjects with normotension, 314 with INH (18.1%), and 945 with overt diurnal hypertension (54.5%). Prevalence of INH was not different between sex or age. Of INH, 71.3% (n=224) was caused by elevated diastolic blood pressure. After multivariable adjustment, INH showed higher pulse wave velocity (
P
<0.001) and central systolic blood pressure (
P
<0.001), left ventricular mass index (
P
=0.026), and worse left ventricular diastolic function (early diastolic mitral annular velocity) (
P
<0.001) than normotension. Mean white matter hyperintensity scores of INH were not different from normotension (
P
=0.321), but the odds for white matter hyperintensity presence were higher in INH than normotension (odds ratio, 1.504 [95% CI, 1.097–2.062];
P
=0.011).

Conclusions
INH was common in the general population and associated with increased arterial stiffness, left ventricular hypertrophy, and diastolic dysfunction. White matter hyperintensity was more likely to be present in the INH group than in the normotension group. The use of ambulatory blood pressure monitoring should be encouraged to identify masked INH and prevent the occurrence of cardiovascular events.
Issue Mapping Strategy: Process of Discovery, Places of Invention and Design Process Fallacies
Authors: Buchanan Kaja Tooming 
Published: October 2022

Abstract
In this article I explore the challenges faced in design practice, where the approach to inquiry depends on understanding the context as a whole with all of its interconnected parts, and its successful transformation from one developmental phase to another. The specific goal of this article is to reflect on the meaning behind and the significance of the Issue Mapping Strategy in the exploratory research process of problem finding and discuss challenges encountered in the process of discovery that might lead to invalid topics and thus to design process fallacies. Therefore, this article explores three major areas of concern—places of invention, process of invention and product of invention—where the risk for design process fallacies is greatest. The significance of discovering commonplaces of arguments and the process of reasoning that help to identify issues in problematic situations is discussed and examples are given. The Issue Mapping strategy is useful in all of the cases that focus on problem finding in complex environments and situations of uncertainty in human experience.
Contemporary Haredi Yiddish Bilingual Pedagogical Materials
Authors: Belk Zoë , Benedict Eliyahu , Kahn Lily , Yampolskaya Sonya 
Published: October 2022

Abstract
This article examines Hebrew- and English-medium pedagogical materials aimed at Haredi learners of Yiddish. Our main findings are 1) the materials are produced by and for the community, which reflects the commonly held Haredi view that knowledge of Yiddish is a key element of in-group identity and therefore must be maintained and taught, 2) the learning materials tend to adopt an inductive approach informed by the traditional Ashkenazic taytsh educational model, where forms and structures are absorbed through exposure, rather than a deductive one, which differs from most non-Haredi Yiddish pedagogical resources, 3) some features (e.g., personal pronouns) presented in the materials are more conservative than those typically used in spoken Haredi Yiddish, and there is considerable variation among the different resources vis-à-vis the grammatical elements presented (e.g., noun case and gender, which supports earlier research demonstrating that these features are absent from or in flux in Contemporary Hasidic Yiddish).
The Vertical Middepth Ocean Density Profile: An Interplay between Southern Ocean Dynamics and Interior Vertical Diffusivity
Authors: Yang Xiaoting , Tziperman Eli 
Published: October 2022

Abstract
The middepth ocean temperature profile was found by Munk in 1966 to agree with an exponential profile and shown to be consistent with a vertical advective–diffusive balance. However, tracer release experiments show that vertical diffusivity in the middepth ocean is an order of magnitude too small to explain the observed 1-km exponential scale. Alternative mechanisms suggested that nearly all middepth water upwells adiabatically in the Southern Ocean (SO). In this picture, SO eddies and wind set SO isopycnal slopes and therefore determine a nonvanishing middepth interior stratification even in the adiabatic limit. The effect of SO eddies on SO isopycnal slopes can be understood via either a marginal criticality condition or a near-vanishing SO residual deep overturning condition in the adiabatic limit. We examine the interplay between SO dynamics and interior mixing in setting the exponential profiles of σ2 and ∂zσ2. We use eddy-permitting numerical simulations, in which we artificially change the diapycnal mixing only away from the SO. We find that SO isopycnal slopes change in response to changes in the interior diapycnal mixing even when the wind forcing is constant, consistent with previous studies (that did not address these near-exponential profiles). However, in the limit of small interior mixing, the interior ∂zσ2 profile is not exponential, suggesting that SO processes alone, in an adiabatic limit, do not lead to the observed near-exponential structures of such profiles. The results suggest that while SO wind and eddies contribute to the nonvanishing middepth interior stratification, the exponential shape of the ∂zσ2 profiles must also involve interior diapycnal mixing.
Comparison of Optical Flow Derivation Techniques for Retrieving Tropospheric Winds from Satellite Image Sequences
Authors: Apke Jason M. , Noh Yoo-Jeong , Bedka Kristopher 
Published: October 2022

Abstract
This study introduces a validation technique for quantitative comparison of algorithms that retrieve winds from passive detection of cloud- and water vapor–drift motions, also known as atmospheric motion vectors (AMVs). The technique leverages airborne wind-profiling lidar data collected in tandem with 1-min refresh-rate geostationary satellite imagery. AMVs derived with different approaches are used with accompanying numerical weather prediction model data to estimate the full profiles of lidar-sampled winds, which enables ranking of feature tracking, quality control, and height-assignment accuracy and encourages mesoscale, multilayer, multiband wind retrieval solutions. The technique is used to compare the performance of two brightness motion, or “optical flow,” retrieval algorithms used within AMVs, 1) patch matching (PM; used within operational AMVs) and 2) an advanced variational optical flow (VOF) method enabled for most atmospheric motions by new-generation imagers. The VOF AMVs produce more accurate wind retrievals than the PM method within the benchmark in all imager bands explored. It is further shown that image regions with low texture and multilayer-cloud scenes in visible and infrared bands are tracked significantly better with the VOF approach, implying VOF produces representative AMVs where PM typically breaks down. It is also demonstrated that VOF AMVs have reduced accuracy where the brightness texture does not advect with the mean wind (e.g., gravity waves), where the image temporal noise exceeds the natural variability, and when the height assignment is poor. Finally, it is found that VOF AMVs have improved performance when using fine-temporal refresh-rate imagery, such as 1- versus 10-min data.
Increased dislocation rates following total hip arthroplasty in patients with ankylosing spondylitis
Authors: Chung Brian C , Stefl Michael , Kang Hyunwoo Paco , Hah Raymond J , Wang Jeffrey C , Dorr Lawrence D , Heckmann Nathanael D 
Published: October 2022

Background: Patients with ankylosing spondylitis (AS) experience abnormal spinopelvic motion due to chronic inflammation of the axial skeleton, predisposing them to impingement and dislocation. The purpose of this study was to evaluate total hip arthroplasty (THA) dislocation rates in AS patients and evaluate the effects of age and gender on dislocation risk. Methods: Patients who underwent primary THA from 2005 to 2014 were identified using the PearlDiver database. AS patients were compared to age- and gender-matched controls without AS. Patients with a history of spine pathology or spine surgery were excluded. Univariate analyses were performed based on age and sex to evaluate dislocation rates at 90 days, 6 months, 1 year, and 5 years postoperatively. Results: A total of 2792 THA patients (59.6% male) with AS were identified and compared to an age- and gender-matched control group of 5582 THA patients (59.5% male) without AS or known spine pathology. At final follow-up, there were 96 dislocations (3.4%) in the AS group and 138 (2.5%) dislocations in the control group (OR 1.40; 95% CI, 1.08–1.83; p = 0.0118). AS patients ⩾70 years old had higher dislocation rates at all time points (OR range, 1.75–2.09; p < 0.05) compared to controls. At 5-year follow-up, dislocation-free survivorship was 95.7% (95% CI, 94.5–96.9%) for AS patients ⩾70 years old compared to 97.3% (95% CI, 96.6–98.0%) for patients ⩾70 years old without AS. Conclusions: Older AS patients have higher dislocation rates following THA. This effect is likely related to decreased spinopelvic motion in the sagittal plane, predisposing patients to impinge and dislocate.
Impact of Isometric Exercise in Adolescents With End Stage Kidney Disease and Unsuitable Vessels For An Autologous Arteriovenous Fistula
Authors: Ramírez-Senent Belén , Aragoncillo Inés , Ligero José Manuel 
Published: October 2022

Introduction Despite the lack of calcification, to perform a native Arteriovenous Fistula (AVF) in young patients may pose a challenge due to small vessel diameter. We report a case series with no options of AVF in which vessel caliber improvement after isometric exercise allowed for radiocephalic fistula creation in all of them. Methods Since 2017 to 2019, four patients were referred to our unit to create an AVF. Following a first assessment with physical examination and doppler ultrasound, none of them were eligible for AVF performance due to small vessel caliber. Once they were considered unsuitable for it, they started an isometric exercise program. Results Age ranged from 13 to 19 years. There were three males and one female. Two were in predialysis and two in hemodialysis program. Initial diameters of the forearm cephalic vein and the radial artery respectively were: case A < 1.5/2.3 mm, case B 1.5/1.6 mm, case C < 1.5/1.6 mm and case D 2.1/1.3 mm. Median duration of exercise program was 13 weeks (range 5-23). Post-exercise vessel diameters were: case A 2.7/2.3 mm, case B 2.5/2 mm, case C 2.8/1.8 mm and case D 2.7/2 mm. Radiocephalic AVF were performed in the four cases. After a median follow up of 19 months (range 9-30 months), 75% of patients required further interventions but all of them had a functional AVF. Conclusions In these four cases isometric preoperative exercise allowed the creation of AVF. Without the improvement in vessel diameter observed afterwards, all of them would have been rejected for AVF performance. Despite the high rate of adjunctive interventions needed, given the safety of the program and the potential risks of Central Venous Catheters, we consider it a valuable option.
Prognostic factors for persistent pain after a distal radius fracture: a systematic review
Authors: Rolls Catherine , Van der Windt Danielle A , McCabe Candy , Babatunde Opeyemi O , Bradshaw Elizabeth 
Published: October 2022

Introduction The aim of this systematic review was to synthesize the evidence regarding prognostic factors for persistent pain, including Complex Regional Pain Syndrome (CRPS), after a distal radius fracture (DRF), a common condition after which persistent pain can develop. Methods Medline, Pubmed, Embase, Psychinfo, CINAHL, BNI, AMED and the Cochrane Register of Clinical Trials were searched from inception to May 2021 for prospective longitudinal prognostic factor studies investigating persistent pain in adults who had sustained a DRF. The Quality in Prognostic Studies (QUIPS) tool and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework were used to assess the strength of evidence. Results A search yielded 440 studies of which 7 studies met full eligibility criteria. From five studies we found low evidence for high baseline pain or an ulnar styloid fracture as prognostic factors for persistent pain, and very low evidence for diabetes or older age. From two studies, investigating an outcome of CRPS, there was low evidence for high baseline pain, slow reaction time, dysynchiria, swelling and catastrophising as prognostic factors, and very low evidence for depression. Sex was found not to be a prognostic factor for CRPS or persistent pain. Conclusions The associations between prognostic factors and persistent pain following a DRF are unclear. The small number of factors investigated in more than one study, along with poor reporting and methodological limitations contributed to an assessment of low to very low strength of evidence. Further prospective studies, investigating psychosocial factors as candidate predictors of multidimensional pain outcomes are recommended.
Giant Enhancement of Second-Harmonic Generation in Hybrid Metasurface Coupled MoS2 with Fano-Resonance Effect
Authors: Xie Yunfei , Yang Liuli , Du Juan , Li Ziwei 
Published: October 2022

AbstractPlasmonic nanostructures have been regarded as potential candidates for boosting the nonlinear up-conversion rate at the nanoscale level due to their strong near-field enhancement and inherent high design freedom. Here, we design a hybrid metasurface to realize the moderate interaction of Fano resonance and create the dual-resonant mode-matching condition to facilitate the nonlinear process of second harmonic generation (SHG). The hybrid metasurface presents dipolar and octupolar plasmonic modes near the fundamental and doubled-frequency wavelengths, respectively, further utilized to enhance the SHG of low-dimensional MoS2 semiconductors. The maximum intensity of SHG in hybrid metasurface coupled MoS2 is more than ten thousand times larger than that of other structure-units coupled MoS2. The conversion efficiency is reported to be as high as 3.27 × 10−7. This work paves the way to optimize nonlinear light–matter interactions in low-dimensional structures coupled with semiconductors.
Microbial features of mature and abandoned soils in refractory clay deposits
Authors: Zverev Aleksei , Kimeklis Anastasiia , Kichko Arina , Gladkov Grigory , Andronov Evgeny , Abakumov Evgeny 
Published: October 2022

AbstractProcesses of soil restoration in anthropogenically disturbed soils is an urgent topic in modern ecology and nature management. Being mediator between mineral soil composition and plant vegetation, soil microbial community is important factor of soil restoration processes. Analysis of main soil nutrition components followed by 16S amplicon sequencing are sufficient methods for primary analysis of novel locations. Here is the primary analysis in a novel location in Northwest Europe (Russia). Main nutrition parameters (pH, P, Na and NH4+) and 16S rDNA Illumina amplicons were explored in abandoned soils from sandy pit quarry (2 sites) and refractory clay mining dumps (4 sites).Microbial communities of mature soils and dumps are variable and different in terms both nutritional and microbial components. pH, N and TOC are strong predictors for microbial composition. Dumps of refractory clays pQ_2 are non-developed soils, highly acidic and form specific microbial community. Differences between dumps and mature soils in both pre-quaternary and quaternary soils are connected with specific bacterial taxa. Those taxa are connected more with plant composition, not the soil properties themselves. The exact changes in microbial community are unique for different soils and areas.Graphical Abstract
The diurnal emission of floral scent in Oncidium hybrid orchid is controlled by CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) through the direct regulation on terpene synthase
Authors: Yeh Chao-Wei , Zhong Hui-Qin , Ho Yung-Feng , Tian Zhi-Hong , Yeh Kai-Wun 
Published: October 2022

Abstract
Background
To adapt the periodic fluctuation of environmental factors, plants are subtle to monitor the natural variation for the growth and development. The daily activities and physiological functions in coordination with the natural variation are regulated by circadian clock genes. The circadian emission of floral scents is one of the rhythmic physiological activities controlled by circadian clock genes. Here, we study the molecular mechanism of circadian emission pattern of ocimene and linalool compounds in Oncidium Sharry Baby (Onc. SB) orchid.

Results
GC-Mass analysis revealed that Onc. SB periodically emitted ocimene and linalool during 6 to 14 o’clock daily. Terpene synthase, one of the key gene in the terpenoid biosynthetic pathway is expressed in coordination with scent emission. The promoter structure of terpene synthase revealed a circadian binding sequence (CBS), 5’-AGATTTTT-3’ for CIRCADIAN CLOCK ASSOCIATED1 (CCA1) transcription factor. EMSA data confirms the binding affinity of CCA1. Transactivation assay further verified that TPS expression is regulated by CCA1. It suggests that the emission of floral scents is controlled by CCA1.

Conclusions
The work validates that the mechanism of circadian emission of floral scents in Onc. Sharry Baby is controlled by the oscillator gene, CCA1(CIRCADIAN CLOCK ASSOCIATED 1) under light condition. CCA1 transcription factor up-regulates terpene synthase (TPS) by binding on CBS motif, 5’-AGATTTTT-3’ of promoter region to affect the circadian emission of floral scents in Onc. SB.
Model-based evaluation of the impact of prophylactic vaccination applied to Ebola epidemics in Sierra Leone and Democratic Republic of Congo
Authors: Potluri Ravi , Kumar Amit , Oriol-mathieu Valérie , Van Effelterre Thierry , Metz Laurent , Bhandari Hitesh 
Published: October 2022

Abstract
Background
Protection by preventive Ebola vaccines has been demonstrated in clinical trials, but a complete picture of real-world effectiveness is lacking. Our previous study modeling the impact of preventively vaccinating healthcare workers (HCW) alone or with a proportion of the general population (GP) estimated significant reductions in incidence and mortality. The model assumed 100% vaccine efficacy, which is unlikely in the real world. We enhanced this model to account for lower vaccine efficacy and to factor in reduced infectiousness and lower case fatality rate in vaccinated individuals with breakthrough infections.

Methods
The previous model was enhanced to still permit a risk, although lower, for vaccinated individuals to become infected. The enhanced model, calibrated with data from epidemics in Sierra Leone (SL) and North Kivu, Democratic Republic of the Congo, helped evaluate the impact of preventive Ebola vaccination in different scenarios based on different vaccine efficacy rates (90% and 30% reductions in infection risk in the base and conservative scenarios, respectively; additionally, both scenarios with 50% reductions in infectiousness and mortality) and vaccination coverage among HCWs (30%, 90%) and GP (0%, 5%, and 10%).

Results
The base scenario estimated that, depending upon the proportions of vaccinated HCWs and GP, 33–85% of cases and 34–87% of deaths during the 2014 SL epidemic and 42–89% of cases and 41–89% of deaths during the 2018 North Kivu epidemic would be averted versus no vaccination. Corresponding estimates for the conservative scenario were: 23–74% of cases and 23–77% of deaths averted during the SL epidemic and 31–80% of both cases and deaths averted during the North Kivu epidemic.

Conclusions
Preventive vaccination targeting HCW alone or with GP may significantly reduce the size and mortality of an EVD outbreak, even with modest efficacy and coverage. Vaccines may also confer additional benefits through reduced infectiousness and mortality in breakthrough cases.