bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological and clinical implications of hsa_circ_0086720 in gastric cancer and its clinical application
Authors: Shao Yongfu , Qi Changlei , Yan Jianing , Lu Rongdan , Ye Guoliang , Guo Junming 
Published: March 2022

AbstractBackgroundCircular RNAs (circRNAs) are thought to be vital participants in carcinogenesis and have the characteristics of being stable, specific, and well conserved. However, their clinical significance and application value in gastric cancer (GC) are still poorly understood. Hsa_circ_0086720 was found to be a dysregulated circRNA in GC by microarray screening and was further explored for its clinical significance and application.MethodsHsa_circ_0086720 was detected in GC cell lines, tissues, and plasma, and the clinicopathological correlations were investigated. The existence, stability, origin, and change in the plasma hsa_circ_0086720 level were verified in early GC patients. Moreover, receiver operating characteristic and Kaplan–Meier survival curves were constructed to analyze the diagnostic and prognostic values, and bioinformatics analysis was used to identify the potential functions. Finally, risk factors and nomogram predicting were established.ResultsHsa_circ_0086720 was found to be downregulated in gastric carcinogenesis, and tissue hsa_circ_0086720 was negatively associated with perineural invasion, Borrmann type, disease‐free survival, and overall survival. Hsa_circ_0086720 was stable in circulating plasma and was actively secreted by cells in gastric carcinogenesis. As a biomarker for early GC screening, plasma hsa_circ_0086720 had good sensitivity and specificity, and its stability met the clinical application requirements. Bioinformatics analysis suggested that dysregulated hsa_circ_0086720 has important functions in gastric carcinogenesis. Univariate Cox regression analysis identified factors associated with overall survival time and disease‐free survival time. The nomograms showed good accuracy of predicting survival time.ConclusionHsa_circ_0086720 is a novel biomarker for screening early GC and predicting the prognosis of advanced‐stage patients.
Plasma growth differentiation factor‐15 in patients with “lone” atrial fibrillation
Authors: Li Na , Feng Qian , Yu Fangfang , Zhou Jian , Guo Xueyuan 
Published: March 2022

AbstractBackgroundGrowth differentiation factor‐15 (GDF‐15) is a member of the transforming growth factor β superfamily, correlated with various stimuli, including cardiovascular disease. The association between plasma GDF‐15 level and “lone” AF, that is, AF of unknown etiology (UeAF), is uncertain.MethodsAll patients aged 60 years or younger. AF patients were hospitalized for primary catheter ablation. Patients with sinus rhythm admitted for other diseases during the same period were included in the control group. ELISA was used to measure plasma GDF‐15 concentrations.Results60 UeAF patients, 60 paroxysmal AF (PAF) patients, and 70 control patients were enrolled. The mean age was 44.6 years. In the UeAF group, no patients had traditional clinical risk factors. The plasma GDF‐15 level in the UeAF group was (1028.5 ± 180.5) pg/ml, higher than in the control group, and moderately lower than in the PAF group. In all patients, positive correlations were found between plasma GDF‐15 level and age (R = 0.210, p < 0.05), and between plasma GDF‐15 level and left atrial diameter (LAD; R = 0.338, p < 0.05; in the UeAF group: R = 0.475, p < 0.05; in the PAF group: R = 0.504, p < 0.05).ConclusionsOur study first investigated the role of GDF‐15 in UeAF. The plasma GDF‐15 level in UeAF patients was higher than in sinus rhythm patients and lower than in PAF patients. Moreover, GDF‐15 was positively correlated with age and LAD. The role of GDF‐15 in UeAF needs further study.
Potential roles of sodium‐glucose co‐transporter 2 inhibitors in attenuating cardiac arrhythmias in diabetes and heart failure
Authors: Attachaipanich Tanawat , Chattipakorn Siriporn C. , Chattipakorn Nipon 
Published: March 2022

AbstractSodium‐glucose co‐transporter 2 (SGLT‐2) inhibitors are antidiabetic drugs that have been shown to exert cardiovascular benefits. Their benefits including a reduction of cardiovascular events and worsening heart failure have been extended to nondiabetic patients with high‐risk. Although both heart failure and diabetes are known to increase risk of cardiac arrhythmias, the effects of SGLT‐2 inhibitors on arrhythmia reduction and their underlying mechanisms are still not fully understood. This review aims to summarize the current available evidence ranging from basic research to clinical reports regarding the potential benefits of SGLT‐2 inhibitors against cardiac arrhythmias. Previous in vitro and in vivo studies using various models including heart failure and diabetes are comprehensively summarized to examine the evidence of how SGLT‐2 inhibitors affect cardiac action potential, cellular ion currents, calcium ion homeostasis, and cardiac mitochondrial function. Clinical reports investigating the association between SGLT‐2 inhibitors and arrhythmias including atrial fibrillation and ventricular arrhythmias are also comprehensively summarized. Valuable information obtained from this review can be used to encourage further clinical investigations to warrant the potential use of SGLT‐2 inhibitors against cardiac arrhythmias in both diabetic and heart failure settings.
Defective endoplasmic reticulum stress response via X box‐binding protein 1 is a major cause of poor liver regeneration after partial hepatectomy in mice with non‐alcoholic steatohepatitis
Authors: Miyazaki Katsuki , Saito Yu , Ichimura‐Shimizu Mayuko , Imura Satoru , Ikemoto Tetsuya , Yamada Shinichiro , Tokuda Kazunori , Morine Yuji , Tsuneyama Koichi , Shimada Mitsuo 
Published: March 2022

AbstractBackgroundNon‐alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Poor regeneration after hepatectomy in NAFLD is well recognized, but the mechanism is unclear. Endoplasmic reticulum (ER) stress plays an important role in the development of NAFLD. Here, we show that an impaired ER stress response contributes to poor liver regeneration in partially hepatectomized mice.MethodsNon‐alcoholic fatty liver (NAFL) or non‐alcoholic steatohepatitis (NASH) was induced in mice using our patented feed and 70% partial hepatectomy (PH) was performed. Mice were sacrificed 0, 4, 8, 24, or 48 hours, or 7 days after PH, and liver regeneration and the mRNA expression of ER stress markers were assessed.ResultsNon‐alcoholic fatty liver disease activity score was calculated as 4–6 points for NAFL and 7 points for NASH. NASH was characterized by inflammation and high ER stress marker expression before PH. After PH, NASH mice showed poorer liver regeneration than controls. High expression of proinflammatory cytokine genes was present in NASH mice 4 hours after PH. Xbp1‐s mRNA expression was high in control and NAFL mice after PH, but no higher in NASH mice.ConclusionsDysfunction of the ER stress response might be a cause of poor liver regeneration in NASH.
(Re)making the margins: Frontier assemblages and brokerage in Hambantota, Sri Lanka
Authors: Goodhand Jonathan , Walton Oliver 
Published: March 2022

AbstractThis article examines the dynamics of brokerage surrounding two moments of rupture (the tsunami and the end of the war) in Hambantota, a district in southern Sri Lanka and a key site of frontier development. We contrast the two development assemblages that emerged from these moments, examining how structural transformations shape the dynamics of brokerage, and how brokers mediate the effects of these transformations. By tracing the shifting fortunes of a local government broker, we reveal the changing power dynamics within these two assemblages, whilst highlighting how moments of rupture both open and shut down brokerage spaces.
Appreciating social science research on gratitude: An integrative review for organizational scholarship on gratitude in the workplace
Authors: Locklear Lauren R. , Sheridan Sharon , Kong Dejun Tony 
Published: March 2022

SummaryThough gratitude research in organizational behavior (OB) is nascent, this emotion has a rich history in the social sciences. Research has shown gratitude to promote prosocial behaviors, encourage personal well‐being, and foster interpersonal relationships. However, gratitude research has been siloed among these three outcomes of gratitude (moral, wellness, and relational). Similarly, past reviews of gratitude have focused on only one group of outcomes, one of its forms (trait, state, or expressed), or empirical findings without emphasis on the theoretical underpinnings. In contrast, this review recognizes that each type of gratitude, its functions, and outcomes are part of a single process model of gratitude. As such, in the current review, we provide a comprehensive assessment of gratitude in the social sciences by distilling and organizing the literature per our process model of episodic gratitude. Then, we translate the insights for management scholars, highlighting possible differences and synergies between extant research and workplace gratitude thereby helping advance “gratitude science” in the workplace. In all, this review (a) examines definitions and operationalizations of gratitude and provides recommendations for organizational research; (b) proposes a process model of episodic workplace gratitude as a conceptual map to guide future OB research on gratitude; (c) reviews empirical gratitude research through the lens of our process model; and (d) discusses the current state of the literature, important differences for workplace gratitude, and future directions for organizational scholars.
Thoracic surgery with geriatric assessment and collaboration can prepare frail older adults for lung cancer surgery
Authors: Cooper Lisa , Gong Yusi , Dezube Aaron R. , Mazzola Emanuele , Deeb Ashley L. , Dumontier Clark , Jaklitsch Michael T. , Frain Laura N. 
Published: March 2022

AbstractBackground and ObjectivesWe assessed frailty, measured by a comprehensive geriatric assessment‐based frailty index (FI‐CGA), and its association with postoperative outcomes among older thoracic surgical patients.MethodsPatients aged ≥65 years evaluated in the geriatric‐thoracic clinic between June 2016 through May 2020 who underwent lung surgery were included. Frailty was defined as FI‐CGA > 0.2, and "occult frailty", a level not often recognized by surgical teams, as 0.2 < FI‐CGA < 0.4. A qualitative analysis of geriatric interventions was performed.ResultsSeventy‐three patients were included, of which 45 (62%) were nonfrail and 28 (38%) were frail. “Occult frailty” was present in 23/28 (82%). Sixty‐one (84%) had lung malignancy. Geriatric interventions included delirium management, geriatric‐specific pain and bowel regimens, and frailty optimization. More sublobar resections versus lobectomies (61% vs. 25%) were performed among frail patients. Frailty was not significantly associated with overall complications (odds ratio [OR]: 2.4; 95% confidence interval [CI]: 0.88–6.44; p = 0.087), major complications (OR: 2.33; 95% CI: 0.48–12.69; p = 0.293), discharge disposition (OR: 2.8; 95% CI: 0.71–11.95; p = 0.141), or longer hospital stay (1.3 more days; p = 0.18).ConclusionFrailty and “occult frailty” are prevalent in patients undergoing lung surgery. However, with integrated geriatric management, these patients can safely undergo surgery.
Overall survival in abdominal wall sarcoma treated with curative intent surgery: A retrospective study from two European referral centres
Authors: Tattersall Hannah L. , Baia Marco , Messina Valentina , Borghi Alessandra , Tirotta Fabio , Almond Max , Desai Anant , Ford Samuel J. , Gronchi Alessandro 
Published: March 2022

AbstractIntroductionPrimary abdominal wall sarcomas are rare, heterogeneous tumours. The mainstay of management is surgery, although local recurrences (LR) and distant metastases (DM) are common.ObjectivesOverall survival (OS) and disease‐free survival (DFS) were primary outcomes; factors associated with prognosis secondary outcomes.Materials and MethodsPatients undergoing surgery of primary abdominal wall sarcomas between April 2008 and May 2018 were identified at two referrals centres for sarcoma surgery. Patient demographics, tumour and treatment‐related characteristics were recorded and analysed.ResultsA cohort of 65 patients underwent surgical resection with a median follow‐up of 56 months, 5‐year OS and DFS were 69% and 71%, respectively. Eleven patients (16.9%) experienced a recurrence event: 6 LR (9.2%), 10 DM (15.4%) and 5 both (7.7%). At univariate analysis, size (p = 0.03), grade (p = 0.001) and depth (p = 0.04) were associated with OS while size (p = 0.02) was associated with DFS. No significant relationship with tumour depth, type of surgery, surgical margin status or neo‐/adjuvant treatment was demonstrated.ConclusionRecurrence events are less common following treatment of abdominal wall sarcomas if compared to extremities STSs, but size (≥5 cm), high malignancy grade (FNCLCC 3) and depth are associated with worse OS.
Cirrhotic cardiomyopathy: Appraisal of the original and revised criteria in predicting posttransplant cardiac outcomes
Authors: Spann Ashley , Coe Christopher , Ajayi Teminioluwa , Montgomery Garren , Shwetar Mohammed , Oje Adesola , Annis Jeffrey , Slaughter James C. , Alexopoulos Sophoclis , Brittain Evan , Izzy Manhal 
Published: March 2022

Abstract
Cardiovascular disease (CVD) significantly contributes to morbidity and mortality after liver transplantation (LT). Cirrhotic cardiomyopathy (CCM) is a risk factor for CVD after transplant. CCM criteria were originally introduced in 2005 with a revision proposed in 2020 reflecting echocardiographic technology advancements. This study assesses the two criteria sets in predicting major adverse cardiac events (MACE) after transplant. This single‐center retrospective study reviewed adult LT recipients between January 1, 2009, and December 31, 2018. Patients with insufficient pre‐LT echocardiographic data, prior ischemic heart disease, portopulmonary hypertension, or longitudinal care elsewhere were excluded. The primary composite outcome was MACE (arrhythmia, heart failure, cardiac arrest, and/or cardiac death) after transplant. Of 1165 patients, 210 met the eligibility criteria. CCM was present in 162 patients (77%) per the original criteria and 64 patients (30%) per the revised criteria. There were 44 MACE and 31 deaths in the study period. Of the deaths, 38.7% occurred secondary to CVD. CCM defined by the original criteria was not associated with MACE after LT (p = 0.21), but the revised definition was significantly associated with MACE (hazard ratio [HR], 1.93; 95% confidence interval, 1.05–3.56; p = 0.04) on multivariable analysis. Echocardiographic variable analysis demonstrated low septal e’ as the most predictive variable for MACE after LT (HR, 3.45; p < 0.001). CCM, only when defined by the revised criteria, was associated with increased risk for MACE after LT, validating the recently revised CCM definition. Abnormal septal e’, reflecting impaired relaxation, appears to be the most predictive echocardiographic criterion for MACE after LT.
Development of Universal and Clickable Film by Mimicking Melanogenesis: On‐Demand Oxidation of Tyrosine‐Based Azido Derivative by Tyrosinase
Authors: Bisht Himani , Jeong Jaehoon , Hong Yubin , Park Suho , Hong Daewha 
Published: March 2022

AbstractA tyrosine‐based azido derivative (TBAD) that permits both substrate‐independent surface coating and clickable film functionalization by mimicking natural melanogenesis is synthesized here. In contrast to catechol derivatives, which are generally susceptible to oxidation by air under ambient conditions, the monophenol‐based TBAD remains stable under alkaline and neutral conditions and is activated to oxidized quinone in situ by tyrosinase to initiate melanin‐like polymerization. The resulting poly(TBAD) film can be formed on various substrates including noble metals, metal oxides, and synthetic polymers, which can undergo click reaction with terminal alkyne moieties on the entire surface or a specific region through Cu(I)‐catalyzed azide‐alkyne cycloaddition. The enzyme‐mediated coating can rapidly form thin films (≈10 nm) and produce a uniform film morphology, which are important aspects in surface chemistry. This on‐demand, clickable coating may become a significant tool for bioconjugation, soft lithography, and labeling techniques.
Serum thyroid‐stimulating hormone is an independent risk factor of recurrent Guillain‐Barré syndrome
Authors: Wang Shi , Luo Zhiya , Peng Tao 
Published: March 2022

AbstractIntroduction/AimsGuillain‐Barré syndrome (GBS) is generally considered to be monophasic, but some patients have recurrences. The purpose of this study was to clarify the possible link between thyroid parameters and recurrent GBS (RGBS) patients in China.MethodsIn this retrospective study we enrolled patients who were admitted to the Department of Neurology of The First Affiliated Hospital of Zhengzhou University from 2014 to 2020 and fulfilled the diagnostic criteria of GBS or Miller Fisher syndrome. We evaluated clinical characteristics; cerebrospinal fluid parameters; and serum levels of thyroid‐stimulating hormone (TSH), free thyroxine, and free triiodothyronine in 320 individuals, including 302 with monophasic GBS and 18 with recurrent GBS.ResultsSerum levels of TSH in monophasic GBS patients were significantly lower than those in RGBS patients (P < .001), whereas FT3 levels were higher in the monophasic GBS group (P = .022). Age at onset, incidence of antecedent illness, time from onset to nadir, proportion with acute inflammatory demyelinating polyradiculoneuropathy, and Hughes Functional Grading Scale score at nadir were statistically significant between monophasic GBS patients and RGBS patients (P < .05). The multivariate regression analysis revealed that antecedent illness, AIDP, and high TSH were independent risk factors for RGBS. Our receiver‐operating characteristic curve analysis showed that the risk of recurrence in GBS patients increases when the TSH concentration is higher than 3.87 μIU/mL.DiscussionOur results demonstrate an association between TSH and RGBS. Oxidative stress is one of the possible interpretations for this association.
Differences in the incidence of urinary tract infections between neurogenic and non‐neurogenic bladder dysfunction individuals performing intermittent catheterization
Authors: Welk Blayne , Lenherr Sara , Santiago‐Lastra Yahir , Norman Holly S. , Keiser Melanie G. , Elliott Christopher S. 
Published: March 2022

AbstractPurposeTo measure the incidence and severity of urinary tract infections (UTI) in intermittent catheter (IC) users with neurogenic and non‐neurogenic diagnoses.Materials and MethodsAdministrative health insurance claims data from the IBM MarketScan® Database between January 1, 2015 and December 31, 2019, were analyzed. New IC‐users with neurogenic lower urinary tract dysfunction (NLUTD); IC‐users without NLUTD (non‐NLUTD); and age‐and‐sex‐matched general population without IC use (GEN) were compared. Individuals were followed for one year after initial IC utilization or random index date for GEN. The primary outcome was a patient seeing a physician or attending a hospital for a UTI (measured with a primary or secondary diagnosis code related to a UTI). UTI incidence, hospitalizations, and length of hospital stay were compared.ResultWe identified 6944 NLUTD, 5102 non‐NLUTD, and 120 426 GEN individuals. The annualized UTI incidence was higher in IC‐users (54.9% NLUTD IC‐users and 38.9% non‐NLUTD IC‐users) compared to GEN individuals (9.8%) (p < 0.001 between groups). Hospitalization for UTI was more common in NLUTD and non‐LUTD (11.3% and 4.0%, respectively) compared with GEN individuals (1.0%) (p < 0.001 between groups). NLUTD individuals had a greater average length of hospital stay than non‐NLUTD (2.2 ± 3.6 vs. 1.6 ± 2.1 days, p < 0.001).ConclusionIC users had a significantly higher incidence of UTIs than the general population. NLUTD IC‐users had a higher incidence of UTIs that required hospitalization compared to non‐NLUTD individuals. Strategies to decrease the patient and healthcare burden of UTIs in those that catheterize should be prioritized.
A nonlocal interface approach to peridynamics exemplified by continuum‐kinematics‐inspired peridynamics
Authors: Laurien Marie , Javili Ali , Steinmann Paul 
Published: March 2022

AbstractIn this contribution, we present a novel approach on how to treat material interfaces in nonlocal models based on peridynamics (PD) and in particular continuum‐kinematics‐inspired peridynamics (CPD), a novel variationally consistent peridynamic formulation. Our method relies on a nonlocal interface where the material subdomains overlap. Within this region, a kinematic coupling of the two constituents is enforced. The contact is purely geometrical as interaction forces act only between points of the same material. We provide a detailed description of the computational implementation within the framework of CPD, that is in principle applicable to all formulations of PD. A variety of numerical examples for modeling bimaterial interfaces illustrate the utility of the technique for both two‐dimensional and three‐dimensional problems, including examples at large deformations. Our model approaches a local model when the nonlocality parameter, the horizon size, is decreased. The proposed methodology offers a viable alternative to previous approaches in PD, which are essentially imposing mixture rules for the interfacial material parameters.
Benefits of weight loss of 10% or more in patients with overweight or obesity: A review
Authors: Tahrani Abd A. , Morton John 
Published: March 2022

AbstractObjectiveModest weight loss (5%‐10%) is clinically meaningful in patients with overweight or obesity. However, greater weight loss may be required to achieve improvements in or remission of certain weight‐related complications. Therefore, this study reviewed the effect of large weight loss (≥10%). Most studies reporting large weight loss and relevant outcomes used bariatric surgery or lifestyle modifications.ResultsBenefits of large weight loss were observed in patients with various overweight‐ or obesity‐related complications, including improvements in comorbidities such as type 2 diabetes and hypertension. Improvements in glucose metabolism and cardiovascular risk factors were observed in patients who achieved large weight loss through lifestyle interventions or pharmacotherapy (phentermine/topiramate 15/92 mg once daily or subcutaneous semaglutide 2.4 mg once weekly). Other benefits associated with large weight loss included reduced cancer risk and improvements in knee osteoarthritis, sleep apnea, fertility‐related end points, and health‐related quality of life. While costly, bariatric surgery is currently the most cost‐effective intervention, although most weight‐management programs are deemed cost‐effective.ConclusionsOverall, large weight loss has a major beneficial impact on overweight‐ and obesity‐related complications. Large weight loss should be the main treatment target when modest weight loss has had insufficient effects on obesity‐related complications and for patients with severe obesity.