bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experiences and challenges faced by patients with COVID-19 who were hospitalised and participated in a randomised controlled trial: a qualitative study
Authors: Hofstetter Lukas , Tinhof Viktoria , Mayfurth Hannah , Kurnikowski Amelie , Rathkolb Vincent , Reindl-Schwaighofer Roman , Traugott Marianna , Omid Sara , Zoufaly Alexander , Tong Allison , Kropiunigg Ulrich , Hecking Manfred 
Published: October 2022

ObjectivesAs part of a randomised controlled trial, this qualitative study aimed to identify experiences and challenges of hospitalised patients with COVID-19 during illness and treatment (objective 1: COVID-19-related perspectives; objective 2: trial participation-related perspectives).DesignSemistructured interviews following a prespecified interview guide, transcribed verbatim and analysed in accordance with the grounded theory process. Investigator triangulation served to ensure rigour of the analysis.SettingInterviews were embedded in a multicentre, randomised, active-controlled, open-label platform trial testing efficacy and safety of experimental therapeutics for patients with COVID-19 (Austrian Corona Virus Adaptive Clinical Trial).Participants20 patients (60±15 years) providing 21 interviews from 8 June 2020 to 25 April 2021.ResultsQualitative data analysis revealed four central themes with subthemes. Theme 1, ‘A Severe Disease’, related to objective 1, was characterised by subthemes ‘symptom burden’, ‘unpredictability of the disease course’, ‘fear of death’ and ‘long-term aftermaths with lifestyle consequences’. Theme 2, ‘Saved and Burdened by Hospitalization’, related to objective 1, comprised patients describing their in-hospital experience as ‘safe haven’ versus ‘place of fear’, highlighting the influence of ‘isolation’. Theme 3, ‘Managing One’s Own Health’, related to objective 1, showed how patients relied on ‘self-management’ and ‘coping’ strategies. Theme 4, ‘Belief in Medical Research’, related to objective 2, captured patients’ ‘motivation for study participation’, many expressing ‘information gaps’ and ‘situational helplessness’ in response to study inclusion, while fewer mentioned ‘therapy side-effects’ and provided ‘study reflection’. Investigator triangulation with an expert focus group of three doctors who worked at the study centre confirmed the plausibility of these results.ConclusionsSeveral of the identified themes (2, 3, 4) are modifiable and open for interventions to improve care of patients with COVID-19. Patient-specific communication and information is of utmost importance during clinical trial participation, and was criticised by participants of the present study. Disease self-management should be actively encouraged.Trial registration numberNCT04351724.
Effects of chronic disease diagnoses on alcohol consumption among elderly individuals: longitudinal evidence from China
Authors: Hu Yue , Chen Qihui , Zhang Bo 
Published: October 2022

ObjectivesThis study estimates the effect of chronic disease diagnoses (CDDs) on elderly Chinese individuals’ alcohol consumption behaviour.Subjects and participantsOur analysis was applied to a publicly available dataset that covers 5724 individuals aged 50 or above and spans 15 years (2000–2015: six waves) from the China Health and Nutrition Survey.DesignThe outcome variables are elderly individuals’ weekly consumption of alcoholic beverages: beer, red wine, Chinese spirits and total alcohol intake. The explanatory variable of primary interest is the number of chronic diseases diagnosed (including hypertension, diabetes, stroke and myocardial infarction). Other covariates concern sample individuals’ sociodemographic and health-related characteristics. A Chamberlain-Mundlak correlated random-effect Tobit model is adopted to simultaneously account for the clustering of ‘zeros’ in the outcome variable and endogeneity issues such as omitted variables and reverse causality.ResultsOur estimation suggests that, on average, an additional chronic disease diagnosed by medical doctors reduced an elderly Chinese individual’s weekly consumption of beer, red wine and Chinese spirits, respectively, by 1.49 (95% CI −2.85 to –0.13), 0.93 (95% CI −1.63 to –0.23) and 0.89 (95% CI −1.23 to –0.54) ounces. These effects translate into a reduction of 0.95 (95% CI −1.29 to –0.60) ounces in total weekly alcohol consumption and a reduction of 24% (95% CI −0.35 to –0.14) in the incidence of excessive drinking. Further explorations suggest that elderly Chinese individuals’ alcohol consumption is most responsive to diabetes and stroke diagnoses, but the effects vary across different beverages. Moreover, males, rural residents, smokers and those living with non-drinkers respond to CDDs more strongly than their respective counterparts.ConclusionWhile CDDs reduced alcohol consumption among elderly Chinese individuals, they failed to stop all heavy drinkers from excessive drinking. Relevant policies and measures are thus needed to urge heavy drinking patients to quit excessive drinking.
Safety and efficacy of intensive systolic blood pressure lowering after successful endovascular therapy: a post hoc analysis of the BP TARGET trial
Authors: Anadani Mohammad , Maier Benjamin , Escalard Simon , Labreuche Julien , de Havenon Adam , Sabben Candice , Lapergue Bertrand , Mistry Eva A , Gory Benjamin , Spiotta Alejandro M , Richard Sébastien , Sibon Igor , Desilles Jean-Philippe , Blanc Raphael , Piotin Michel , Mazighi Mikaël 
Published: October 2022

BackgroundThe Safety and Efficacy of Intensive Blood Pressure Lowering after Successful Endovascular Therapy in Acute Ischaemic Stroke (BP TARGET) trial demonstrated no benefit from intensive systolic blood pressure (SBP) treatment after successful reperfusion with endovascular therapy. However, it remains unknown if the response to blood pressure treatment is modified by other factors.ObjectiveTo carry out a post hoc analysis of the BP TARGET trial data to determine if the response to blood pressure treatment is modified by factors such as age, history of hypertension, recanalization status, location of occlusion, diabetes, hyperglycemia, or pretreatment with intravenous thrombolysis.MethodsThis is a post hoc analysis of the BP TARGET trial. Patients were divided into groups based on age, diabetes, blood glucose, site of occlusion, history of hypertension, and pretreatment with intravenous thrombolysis. The primary outcome was any intraparenchymal hemorrhage.Results318 patients were included. Diabetes modified the treatment effect on favorable functional outcome (Pheteogenity=0.041). There was a trend towards benefit from intensive SBP treatment in diabetic patients (OR=2.81; 95% CI 0.88 to 8.88; p=0.08) but not in non-diabetic patients (OR=0.75; 95% 0.45 to 126; p 0.28). Age, location of occlusion, admission SBP, pretreatment with intravenous thrombolysis, and history of hypertension did not modify the effect of intensive SBP treatment on any of the outcomes.ConclusionThe effect of SBP lowering treatment was not modified by age, location of occlusion history of hypertension, intravenous thrombolysis, and admission SBP. Diabetes modified the effect of intensive SBP lowering treatment, and there was a trend towards benefit from intensive SBP treatment in diabetic patients. This finding is hypothesis generating and requires further validation.
Progressive and Simultaneous Right and Left Atrial Remodeling Uncovered by a Comprehensive Magnetic Resonance Assessment in Atrial Fibrillation
Authors: Gunturiz‐Beltrán Clara , Nuñez‐Garcia Marta , Althoff Till F. , Borràs Roger , Figueras i Ventura Rosa M. , Garre Paz , Caixal Gala , Prat‐González Susanna , Perea Rosario J. , Benito Eva Maria , Tolosana Jose Maria , Arbelo Elena , Roca‐Luque Ivo , Brugada Josep , Sitges Marta , Mont Lluís , Guasch Eduard 
Published: October 2022

Background
Left atrial structural remodeling contributes to the arrhythmogenic substrate of atrial fibrillation (AF), but the role of the right atrium (RA) remains unknown. Our aims were to comprehensively characterize right atrial structural remodeling in AF and identify right atrial parameters predicting recurrences after ablation.

Methods and Results
A 3.0 T late gadolinium enhanced–cardiac magnetic resonance was obtained in 109 individuals (9 healthy volunteers, 100 patients with AF undergoing ablation). Right and left atrial volume, surface, and sphericity were quantified. Right atrial global and regional fibrosis burden was assessed with validated thresholds. Patients with AF were systematically followed after ablation for recurrences. Progressive right atrial dilation and an increase in sphericity were observed from healthy volunteers to patients with paroxysmal and persistent AF; fibrosis was similar among the groups. The correlation between parameters recapitulating right atrial remodeling was mild. Subsequently, remodeling in both atria was compared. The RA was larger than the left atrium (LA) in all groups. Fibrosis burden was higher in the LA than in the RA of patients with AF, whereas sphericity was higher in the LA of patients with persistent AF only. Fibrosis, volume, and surface of the RA and LA, but not sphericity, were strongly correlated. Tricuspid regurgitation predicted right atrial volume and shape, whereas diabetes was associated with right atrial fibrosis burden; sex and persistent AF also predicted right atrial volume. Fibrosis in the RA was mostly located in the inferior vena cava–RA junction. Only right atrial sphericity is significantly associated with AF recurrences after ablation (hazard ratio, 1.12 [95% CI, 1.01–1.25]).

Conclusions
AF progression associates with right atrial remodeling in parallel with the LA. Right atrial sphericity yields prognostic significance after ablation.
Present Levels of Academic Achievement and Functional Performance: Unravelling the Narratives
Authors: Ruppar Andrea L. , Kurth Jennifer A. , McCabe Katie M. , Toews Samantha G. , McQueston Jessica A. , Johnston Russell 
Published: October 2022

Abstract
In this qualitative study, we analyzed the language used by professionals within iep documents for students with disabilities. Viewing the iep as a narrative, and using positioning theory as guiding framework, statements of present levels of academic and functional performance in iep s for 88 students in grades K-12 in the United States were analyzed. Findings revealed that students were negatively positioned through the skills that were reported, the data that were reported, and problems located in the student rather in the environment. Implications for policy, practice, and research are provided.
2. Human Environmental Aesthetics
Authors: Hamann-Rose Paul Hamann-Rose 
Published: October 2022

This chapter introduces the concepts of the molecular sublime and the molecular grotesque as key aesthetics in twenty-first-century cultural representations of life at the molecular level. The aesthetics of the sublime and the grotesque as they manifest in the cultural imagination of the molecular and the microbial indicate a particular cluster of concerns and anxieties about the relation between the human and the molecular scales. Moreover, imagining the life around us and questioning the often unsettlingly porous boundaries between individual and environment, has acquired special urgency as humanity is attempting to re-define its ecological practices and self-understanding. The epistemological and affective connotations of the sublime and the grotesque can illuminate such human-environment continuities, but also obstruct the self-awareness that would make such connections meaningful to readers and spectators.
This chapter argues that while the sublime affords spectacular vistas on the very small scales of life, it may be the grotesque molecular and microbial distortions of our familiar selves, and the vision of the human body as molecular and microbial landscape, that prove the more productive aesthetic for crossing the distance between the visible and the imagined that often precludes an understanding of how the molecular relates to us. The chapter traces the aesthetics of the molecular sublime and the molecular grotesque across multiple genres, discussing examples from novels, popular science writing and poetry.
Diurnal and Seasonal Variability of Near-Surface Temperature and Humidity in the Maritime Continent
Authors: May P. T. , Trewin B. , Nairn J. R. , Ostendorf B. , Su Chun-Hsu , Moise A. 
Published: October 2022

Abstract
This work examines the diurnal and seasonal variability of near-surface temperature and humidity at several large areas with high population density within the Maritime Continent using the Bureau of Meteorology Atmospheric Regional Reanalysis (BARRA) 12-km-resolution dataset that covers the period 1990–2019. The diurnal cycle is examined in detail, with a key feature being the relatively small diurnal variation of the wet-bulb temperature TWB when compared with the temperature and dewpoint temperature TD. The diurnal variability is strongly modulated by the monsoons with their increased rainfall and cloud cover. The near-surface signals associated with the Madden–Julian oscillation across the domains are relatively weak. Dry and humid temperature extremes are examined for regional and seasonal variability. The dry and moist variable extremes occur at different times of year, but each have spatially coherent structure.

Significance Statement
This paper examines the climatological variations of near-surface temperature and humidity and their extremes in four locations in the “Maritime Continent.” This is important because there are significant variations potentially affecting human and ecosystem health and its resilience to climate change.
Powered Intracapsular Tonsillotomy and Adenoidectomy in Infants ≤36 Months Compared to Older Children: A Retrospective Analysis
Authors: Stahl Avishai , Dagan Or , Nageris Benny , Biadsee Ameen , Ebner Yaniv 
Published: October 2022

Objectives: To evaluate the safety and outcomes of powered intracapsular tonsillotomy and adenoidectomy (PITA) for the treatment of sleep disordered breathing in infants up to 36 months of age compared to older children. Methods: This retrospective analysis included children who underwent PITA from 2013 to 2019 at a single tertiary care medical center. The patients were divided into 2 groups: up to 36 months, and 36 to 72 months. The data were collected from electronic medical records and from a telephone survey based on a modified version of the OSA-18 questionnaire. Post-operative complications, and short- and long-term outcomes were compared. Results: A total of 48 patients met the inclusion criteria for the main study group (up to 36 months of age). They were compared to 59 children 36 to 72 months of age. There were no differences in subjective outcomes between age groups ( P = .65). There were no differences in the frequency of post-operative complications between age groups ( P = .8) or in the number of hospitalization days ( P = .91). Conclusion: The short- and long-term outcomes and safety of PITA for the treatment of sleep disordered breathing in infants up to 36 months of age are similar to those of older children.
The Influence of Robots’ Fairness on Humans’ Reward-Punishment Behaviors and Trust in Human-Robot Cooperative Teams
Authors: Cao Jiajia , Chen Na 
Published: October 2022

Objective Based on social exchange theory, this study investigates the effects of robots’ fairness and social status on humans’ reward-punishment behaviors and trust in human-robot interactions. Background In human-robot teamwork, robots show fair behaviors, dedication (altruistic unfair behaviors), and selfishness (self-interested unfair behaviors), but few studies have discussed the effects of these robots’ behaviors on teamwork. Method This study adopts a 3 (the independent variable is the robot’s fairness: self-interested unfair behaviors, fair behaviors, and altruistic unfair behaviors) × 3 (the moderator variable is the robot’s social status: superior, peer, and subordinate) experimental design. Each participant and a robot completed the experimental task together through a computer. Results When robots have different social statuses, the more altruistic the fairness of the robot, the more reward behaviors, the fewer punishment behaviors, and the higher human–robot trust of humans. Robots’ higher social status weakens the influence of their fairness on humans’ punishment behaviors. Human–robot trust will increase humans’ reward behaviors and decrease humans’ punishment behaviors. Humans’ reward-punishment behaviors will increase repaired human-robot trust. Conclusion Robots’ fairness has a significant impact on humans’ reward-punishment behaviors and trust. Robots’ social status moderates the effect of their fair behavior on humans’ punishment behavior. There is an interaction between humans’ reward-punishment behaviors and trust. Application The study can help to better understand the interaction mechanism of the human–robot team and can better serve the management and cooperation of the human–robot team by appropriately adjusting the robots’ fairness and social status.
Improving adhesive behavior of fiber reinforced composites by incorporating electrospun Polyamide-6,6 nanofibers in joining region
Authors: Esenoğlu Gözde , Barisik Murat , Tanoğlu Metin , Yeke Melisa , Türkdoğan Ceren , İplikçi Hande , Martin Seçkin , Nuhoğlu Kaan , Aktaş Engin , Dehneliler Serkan , İriş Mehmet Erdem 
Published: October 2022

Adhesive joining of fiber reinforced polymer (CFRP) composite components is demanded in various industrial applications. However, the joining locations frequently suffer from adhesive bond failure between adhesive and adherent. The aim of the present study is improving bonding behavior of adhesive joints by electrospun nanofiber coatings on the prepreg surfaces that have been used for composite manufacturing. Secondary bonding of woven and unidirectional CFRP parts was selected since this configuration is preferred commonly in aerospace practices. The optimum nanofiber coating with a low average fiber diameter and areal weight density is succeed by studying various solution concentrations and spinning durations of the polyamide-6.6 (PA 66) electrospinning. We obtained homogeneous and beadles nanofiber productions. As a result, an average diameter of 36.50 ± 12 nm electrospun nanofibers were obtained and coated onto the prepreg surfaces. Prepreg systems with/without PA 66 nanofibers were hot pressed to fabricate the CFRP composite laminates. The single-lap shear test coupons were prepared from the fabricated laminates to examine the effects of PA 66 nanofibers on the mechanical properties of the joint region of the composites. The single-lap shear test results showed that the bonding strength is improved by about 40% with minimal adhesive use due to the presence of the electrospun nanofibers within the joint region. The optical and SEM images of fractured surfaces showed that nanofiber-coated joints exhibited a coherent failure while the bare surfaces underwent adhesive failure. The PA66 nanofibers created better coupling between the adhesive and the composite surface by increasing the surface area and roughness. As a result, electrospun nanofibers turned adhesive failure into cohesive and enhanced the adhesion performance composite joints substantially.
Rates of rare copy number variants in different circumstances among patients with genetic developmental and epileptic encephalopathy
Authors: Lee Sanghoon , Kim Bo Ram , Kim Young Ok 
Published: October 2022

Background: Most patients with developmental and epileptic encephalopathy (DEE) have genetic etiology, which has been uncovered with different methods. Although chromosomal microarray analysis (CMA) has been broadly used in patients with DEE, data is still limited. Methods: Among 560 children (<18 years) who underwent CMA in our hospital between January 2013 and June 2021, 146 patients with developmental delay and recurrent seizures were screened. Patients with major brain abnormalities, metabolic abnormalities, and specific syndromes were excluded. The rate of rare copy number variants (CNVs) was estimated in total and according to seizure-onset age, relation to first seizure with the diagnosis of developmental delay, epilepsy syndromes, and organ anomalies. Results: Among the 110 patients enrolled, the rate of rare CNVs was 16.4%, varying by seizure-onset age: 33.3% in three neonates, 21.2% in 33 infants, 13.3% in 45 early childhood patients, 5.3% in 19 late childhood patients, and 30.0% in 10 adolescents. In relation to the first seizure with the diagnosis of developmental delay, the rates were 3.7%, 22.2%, and 12.5% in “before”, “after”, and “concurrent” subclasses, respectively. The rates of rare CNVs were 16.7% in “other predominantly focal or multifocal epilepsy”, 28.6% in “other predominantly generalized epilepsy (PGE)”, and 15.4% in West syndrome. The rates were 27.8% in minor brain anomalies, 37.5% in facial dysmorphism, and 22.2%, 20.0%, and 57.1% in endocrine, genitourinary and cardiovascular anomalies, respectively. Conclusion: The rate of rare CNVs in patients with genetic DEE was 16.4% in total, which was higher in seizures occurring below the infantile period or after the diagnosis of developmental delay, in PGE, and in the presence of facial dysmorphism or cardiovascular anomalies.
Turkish validity and reliability study of male genital self-image scale (MGSIS)
Authors: Koçak Vesile , Erkal Aksoy Yasemin , Dügeroğlu Sinem 
Published: October 2022

Objective: This study, which was carried out in order to determine the Turkish validity and reliability of the “Male Genital Self-Image Scale” in a population sample of Turkish men, is of methodological type. Methods: In the study, language, content, construct validity, and reliability methods were used for the intercultural adaptation of the scale. The data collection process of the scale was carried out with 336 men who applied to the Family Medicine Polyclinic of a hospital. In the language and content validity phase, the opinions of experts with technical and cultural knowledge were consulted. The data of the study were collected with the Sociodemographic Characteristics Form and the Male Genital Self-Image Scale. Results: As a result of experts evaluation, the Content Validity Ratio value was determined as 0.83. At the stage of construct validity, the suitability of the single-factor model of the items of the Male Genital Self-Image Scale was tested. It was determined that all items contributed significantly to the factor (0.62–0.92). As a result of the Confirmatory Factor Analysis, the measurement model was statistically validated (χ2 = 32.083, p = 0.001, χ2/df = 2.917, RMSEA = 0.076). The Cronbach’s alpha reliability coefficient was calculated as α = 0.92 in the analysis performed to evaluate the internal consistency of Male Genital Self-Image Scale. Conclusion: The results of the study revealed that Male Genital Self-Image Scale is a valid and reliable tool to evaluate genital self-image in Turkish men.