bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm
Authors: Zhao Yuwei , Liu Guanghui , Liang Lei , Yu Zaiwei , Zhang Jian , Zheng Hong , Dai Liying 
Published: October 2022

AbstractPreterm infants face a significant risk of brain injury in the perinatal period, as well as potential long-term neurodevelopmental disabilities. However, preterm children with brain injury lack specific clinical manifestations in the early days. Therefore, timely and accurate diagnosis of brain injury is of vital importance. This study was to explore the diagnostic efficiency of myelin basic protein (MBP) and 8-oxo-deoxyguanosine (8-oxo-dG) serum levels in brain injury of premature infants. A total of 75 preterm infants with gestational age between 28 and 32 weeks and birth weight higher than 1,000 g were prospectively included. MBP serum levels were significantly higher in premature infants with white matter injury (WMI). 8-oxo-dG serum levels were significantly increased in both WMI and periventricular–intraventricular hemorrhages (PIVH). MBP and 8-oxo-dG were significantly correlated. The area under the curve was 0.811 [95% confidence interval (CI) 0.667–0.955;p= 0.002] in MBP and 0.729 (95% CI 0.562–0.897;p= 0.020) in 8-oxo-dG. Therefore, the results showed that high MBP levels indicated a possibility of WMI in the premature brain during the early postnatal period, while high 8-oxo-dG levels were closely related to both WMI and PIVH, thus suggesting that MBP and 8-oxo-dG could be used as potential neuro-markers of preterm brain injury.
High-efficiency SOI-based metalenses at telecommunication wavelengths
Authors: Ryu Taesu , Kim Moohyuk , Hwang Yongsop , Kim Myung-Ki , Yang Jin-Kyu 
Published: October 2022

Abstract
We demonstrated silicon-on-insulator (SOI)-based high-efficiency metalenses at telecommunication wavelengths that are integrable with a standard 220 nm-thick silicon photonic chip. A negative electron-beam resist (ma-N) was placed on top of the Si nanodisk, providing vertical symmetry to realize high efficiency. A metasurface with a Si/ma-N disk array was numerically investigated to design a metalens that showed that a Si/ma-N metalens could focus the incident beam six times stronger than a Si metalens without ma-N. Metalenses with a thick ma-N layer have been experimentally demonstrated to focus the beam strongly at the focal point and have a long depth of field at telecommunication wavelengths. A short focal length of 10 μm with a wavelength-scale spot diameter of approximately 2.5 μm was realized at 1530 nm. This miniaturized high-efficiency metalens with a short focal length can provide a platform for ultrasensitive sensors on silicon photonic IC.
Crystal structure of (E)-3-((4-chlorophenyl)thio)-4-hydroxypent-3-en-2-one, C11H11ClO2S
Authors: Yuan Fei , Guo Ya-Fei , Ma Jun-Ying , Guo Ke-Wen , Xu Zhi-Cong 
Published: October 2022

Abstract
C11H11ClO2S, orthorhombic, P212121 (no. 19), a = 5.7516(7) Å, b = 7.4097(12) Å, c = 27.461(3) Å, V = 1170.3(3) Å3, Z = 4, R

gt
(F) = 0.0564, wR

ref
(F
2) = 0.0990, T = 293 K.
Iron metabolism: pathways and proteins in homeostasis
Authors: Arora Ekta Kundra , Sharma Vibha 
Published: October 2022

Abstract
Iron is essential to human survival. The biological role and trafficking of this trace essential inorganic element which is also a potential toxin is constantly being researched and unfolded. Vital for oxygen transport, DNA synthesis, electron transport, neurotransmitter biosynthesis and present in numerous other heme and non-heme enzymes the physiological roles are immense. Understanding the molecules and pathways that regulate this essential element at systemic and cellular levels are of importance in improving therapeutic strategies for iron related disorders. This review highlights the progress in understanding the metabolism and trafficking of iron along with the pathophysiology of iron related disorders.
“I had already tried that before going to the doctor” – exploring adolescents’ with knee pain perspectives on ‘wait and see’ as a management strategy in primary care; a study with brief semi-structured qualitative interviews
Authors: Andreucci Alessandro , Skovdal Rathleff Michael , Ørskov Reuther Frederikke , Hussein Mariann , Rahimzai Sultana , Linnemann Trine Dorthea , Johansen Simon Kristoffer 
Published: October 2022

Abstract

Objectives
The aim of this study was to examine how the “wait-and-see” recommendation affects adolescents’ understanding of their illness and symptoms and their care-seeking behavior.

Methods
This study included brief qualitative, semi-structured online interviews. Adolescents (age 10–19 years) with long-term knee pain, who had been recommended “wait-and-see” by their general practitioner (GP), were recruited via previous studies and social media. Two researchers conducted brief semi-structured interviews through Microsoft Teams. An interview guide with open questions was created prior to the interviews and updated as new questions emerged. The extracted data was transcribed and analyzed via a reflexive thematic approach in NVivo.

Results
Eight adolescents (mean age 17.8) with longstanding or recurrent knee pain (mean duration 3.5 years) were included. The analysis identified four main themes: (1) The perception of wait and see over time, (2) The GP’s acknowledgement and consideration, (3) experienced limitation from knee pain and (4) the importance of getting a diagnosis. The perception of “wait-and-see” approach changed from positive to negative when adolescents received the recommendation multiple times. Adolescents experienced frustration with their situation and a lack of consideration from their GP made them cautious about seeking additional care. Knee pain significantly limited the adolescents’ physical-and social activities. Receiving a diagnosis was important and helped adolescents dealing with their pain.

Conclusions
The connotation of wait-and-see changed from positive to negative for adolescents when receiving the recommendation multiple times. The participants felt getting a clinical diagnosis was a relief. Furthermore, the lack of consideration and acknowledgement from the GP plays an essential role in the adolescent’s understanding of their knee pain.

Implications
Recommending adolescents to “wait-and-see” multiple times in relation to their knee problems can lead adolescents experience frustration and a lack of consideration from their GP. It would be advisable for GPs to provide adolescents with a diagnosis as it can facilitate them in dealing with their pain and to use simple language when explaining adolescents their condition to improve communication.
A változások szociálpszichológiája és a szociálpszichológia változásai
Authors: Hunyady György 
Published: October 2022

A 19. század végén az úgynevezett szellemtudományok ígérték a történelmi szereplők, fejlemények és időszakok pszichológiai leírását és megértését, ezek értékirányultsága alapján. Az elmúlt évszázad során a szociálpszichológia mint az empirikus humántudományok egyik ága fokozatosan átvette ezt a szerepet. McGuire periodizációjával egyetértően a szerző – az ELTE díszdoktorává avatása alkalmával – a szociálpszichológia fejlődésének öt fázisát jellemezte, mígnem elérte a hierarchikus társadalmi rendszerekkel kapcsolatos attitűdök és érzelmi kontextusok tematikus dominanciáját a jelenben. Amerika történetének társadalmi-politikai kihívásai mély nyomot hagytak ezen szakmai tudományos fejlődésen, és a kelet-közép-európai kutatások megtalálhatják és meg kell találniuk a saját kérdésfeltevéseiket és megközelítéseiket, hogy a továbbiakban kiegyensúlyozott együttműködés alakuljon ki a szociálpszichológia széles tudományterületén.
An infinitive by any other name: On the non-finites in Hungarian, Finnish and Estonian grammars
Authors: Laakso Johanna 
Published: October 2022

AbstractNon-finite verb forms, in-between verbs and nouns and also in-between inflection and derivation, pose challenges to grammar writing. In the largely Latin-based European grammar traditions, three or four main types of non-finites are often distinguished: infinitives, participles, verbal adverbs (gerunds, converbs), and – often most closely connected to the participles but classified as derivation rather than inflection – deverbal noun derivatives. Hungarian, Finnish, and Estonian, the three Uralic state languages with a strong tradition of written cultivation, are situated at the western end of the language family and display a strong “Europeanization” also in their systems of non-finites. Yet, these systems differ greatly even from each other.In this paper, the classification and nomenclature of non-finites in Hungarian grammars are compared with Finnish and Estonian. The Finnish grammar tradition is based on morphological substance but, failing to acknowledge the category of converbs, ends up exploiting the term “infinitive” in a way which is syntactically and semantically meaningless. The Estonian grammars vacillate between an opportunistic use of traditional European grammar terms and a simple listing of forms at a minimal level of abstraction. Hungarian grammars, in turn, present the non-finites in a way which is incompatible with other grammar traditions and is internally contradictory.
DIGITAL TRANSFORMATION STRATEGY: ASSESSMENT OF DIGITAL MATURITY OF THE RUSSIAN ELECTRIC POWER INDUSTRY
Authors: Khobotova L. V. , Neprintseva E. V. , Shubin S. A. 
Published: October 2022

Based on the analysis of domestic and foreign experience of digital transformation and the conducted expert survey, the authors conclude that Russia, in comparison with other countries, does not have a leading position in the implementation of digital technologies. At the same time, the electric power industry being the basic sector of the economy which is responsible for its safe and sustainable development, in terms of digitalization is on the sidelines, yielding to retail, the banking industry, telecommunications and the manufacturing industry. At the same time, digitalisation is a promising direction and can have a significant positive impact on the electric power industry. The purpose of the study is to assess the current level of digital maturity of the electric power industry in Russia, identify the main barriers to digital transformation and develop proposals in order to overcome them.The article uses generalisation, comparative analysis, analyses empirical data of digitalisation in Russia and abroad, conducts a survey of experts in the electric power industry about its digital maturity.
Efficacy and safety of Obex® in overweight and obese subjects: a randomised, double-blind, placebo-controlled clinical trial
Authors: Cabrera-Rode Eduardo , Cubas-Dueñas Ileana , Acosta Janet Rodriguez , Hernández Jeddú Cruz , González Ana Ibis Conesa , Calero Teresa M. González , Domínguez Yuri Arnold , Rodríguez José Hernández , Rodríguez Antonio D. Reyes , Jedd Aimee Álvarez , Valdés Ragmila Echevarría , Espinosa Liudmila Jorge , Belent Onelia Torres , Benavides Zoila Bell , Estévez Elizabeth Senra , Rodríguez Yanet Abreu , Rodríguez Juana del Valle , Julibá Silvia Marín 
Published: October 2022

Abstract

Background
Obex® may be helpful in reducing body weight and fat. The current study was carried out to evaluate the efficacy and safety of Obex® in the treatment of overweight and obese subjects.
Methods
A double-blind, randomised, controlled phase III clinical trial was conducted involving 160 overweight and obese subjects (BMI ≥25.0 and <40 kg/m2) aged 20 to 60 years, who received Obex® (n=80) and placebo (n=80) plus non-pharmacological treatment (physical activity and nutritional counseling). One sachet of Obex® or placebo were administered before the two main meals each day for 6 months. In addition to anthropometric measurements and blood pressure, fasting plasma and 2h glucose levels during the oral glucose tolerance test, lipid profile, insulin, liver enzymes, creatinine, and uric acid (UA) were determined, insulin resistance (HOMA-IR) beta-cell function (HOMA-β) were assessed and insulin sensitivity (IS) was calculated with three indirect indices.
Results
After 3 months of Obex®, 48.3% of the participants (28/58) achieved complete success in reducing both weight and waist circumference by greater than or equal to 5% from baseline, as opposed to 26.0% (13/50) of individuals receiving placebo (p=0.022). Compared to baseline, at 6 months no differences were found between the groups concerning anthropometric and biochemical measurements, except for high-density lipoprotein cholesterol (HDL-c) levels, which were higher in subjects receiving Obex® compared to those receiving placebo (p=0.030). After 6 months of treatment, both groups showed reduced cholesterol and triglyceride levels (p<0.012) compared to baseline value. However, only those intake Obex® showed reduced insulin concentrations and HOMA-IR, improved IS (p<0.05), and decreased creatinine and UA levels (p<0.005).
Conclusions
The consumption of Obex® together with lifestyle changes increased the cardiovascular protective effect (increased HDL-c), contributed to a rapid reduction of weight and waist circumference and improved insulin homeostasis, which did not occur in the placebo group, and appears to be safe as an adjunct at conventional obesity treatment.
Trial registration
Clinical trial protocol was registered in the Cuban public registry of clinical trials under code RPCEC00000267 on 17/04/2018 and also registered in the international registry of clinical trials, ClinicalTrials.gov, under code: NCT03541005 on 30/05/2018.
Does Energy Poverty increases Starvation? Evidence from Sub-Saharan Africa
Authors: Pondie Thierry Messie , Dorothy ENGWALI FON , NKOA Bruno Emmanuel ONGO , DOMGUIA Edmond NOUBISSI 
Published: October 2022

Abstract
In this study, we contribute to the existing literature on energy poverty and food security in Sub-Saharan Africa (SSA). The paper is carried out on a panel of 36 sub-Saharan African countries over the period 2000 to 2020. Adopting several estimation methods, such as fixed effects, Driscoll-Kraay, Lewbel 2SLS and Generalized Method of Moments, we find positive results of energy on food security. In SSA, the energy development index, access to electricity and access to clean energy for cooking positively influence food security. This may encourage policy makers to prioritise investment in off-grid energy for vulnerable households through small-scale power systems, which can promote food security by instantly affecting local food production, preservation and preparation and contribute to people's sustainability and contribute to preserve the environment.
The Impact of Cartoon Masks &amp; Standard Masks on Doctor-Patient Communication in Pediatrics
Authors: Rahman Mukadas , Zhao Aonan , Li Xiaoli , Su Xiaorong , Jiang Jie , Tong Jianjing 
Published: October 2022

Abstract
Background: As the COVID-19 pandemic rages rampantly worldwide, wearing masks has become necessary. However, it remains unexplored concerning the impact of different types of masks on communication between pediatricians and patients.
Objective: Against this backdrop, this study aims to investigate the influence of cartoon masks and standard masks on doctor-patient communication in pediatric treatment.
Research design: A randomized controlled trial was conducted in the pediatric clinic of Ruijin Hospital affiliated to Shanghai Jiao Tong University between April and August 2021. Parents were divided into cartoon mask group and standard mask group based on the masks worn by the attending doctors. A questionnaire was conducted immediately after the visit to discern the demographic variables and evaluate the effect of communication. Statistical analysis was performed using SPSS 23.0 and ROST CM6 Chinese Sentiment Dictionary.
Results: 200 valid questionnaires are subject to the statistical analysis. Results suggest that parents are in favor of cartoon masks, which can better reflect the sincerity of pediatricians (100 vs 88, p < 0.001) and imply that they are really listening (94 vs 84, p = 0.024). Besides, cartoon masks indicate more attention is paid to children (99 vs 85, p < 0.001). It is shown that parents tend to comment more positively on pediatricians wearing cartoon masks (74.28% vs 28.57%). However, 60% of pediatricians indicate they are less likely to choose cartoon masks.
Conclusion: Results show parents prefer doctors who wear cartoon masks, for it shows their sincerity and really listening, and much more attention is paid to their children’s feelings. Therefore, this study argues that cartoon masks exert a largely positive impact on the effectiveness of doctor-patient communication and thus they are highly recommended for pediatricians.
CD97 Expression Level and Its Effect on Cell Adhesion in Preeclampsia
Authors: ATIGAN AYHAN , TAN SEMİH , ÇETİN HÜLYA , GÜLER ÖMER TOLGA , ÖZDAMAR SAİM , KARAKAYA YELİZ ARMAN 
Published: October 2022

Abstract
Objectives: Cellular interactions and cell adhesion underlie preeclampsia (PE). The aim of the current study is to investigate the role of cell adhesion molecules such as CD97, neural (N)-cadherin, epithelial (E) -cadherin and integrin beta-4 in PE.
Methods: This prospective study included 20 pregnant women with PE and a control group of 16 healthy pregnant women who were matched for age, gestational age, gravida and parity. Standard blood tests and placental cell adhesion molecule immunohistochemical staining were examined.
Results: The creatinine, uric acid and lactate dehydrogenase (LDH) levels from standard blood tests were found to be statistically higher in the PE group (p=0.002, p=0.000, p=0.001; respectively). In the PE group, the CD97 maternal serum level was statistically significantly lower, as was its immunohistochemical expression in placental sections (p=0.028, p=0.000; respectively). The E-cadherin expression score was statistically higher in the PE group compared to the control group (3,65±1,84 vs 2,06±1,76 respectively; p=0.003). The N-cadherin expression score was statistically lower in the PE group compared to the control group (1,50±0,82 vs 2,43±1,59 respectively; p=0.049). Integrin beta-4 was not statistically different between groups.
Conclusions: Cellular interaction is responsible for PE as in cancer. A balance in intercellular communication, as researched in cancer therapy, may offer the solution in PE.
Keywords: Preeclampsia, Cadherins, CD97, E-cadherin, N-cadherin, Integrin beta-4
A novel technique for large-fragment knock-in animal production without ex vivo handling of zygotes
Authors: Abe Manabu , Nakatsukasa Ena , Natsume Rie , Hamada Shun , Sakimura Kenji , Watabe Ayako , Ohtsuka Toshihisa 
Published: October 2022

AbstractCRISPR/Cas-based genome editing has dramatically improved genetic modification technology.In-situelectroporation called genome editing via oviductal nucleic acid delivery (GONAD), which eliminates the need forex vivoembryo handling, is technically the simplest method for gene transfer and can be performed in laboratories without developmental engineering expertise. However, the use of this method remains challenging in the case of large-fragment knock-in, such as gene expression cassettes. Adeno-associated viruses (AAV) act as donor DNA for homologous recombination in infectious cells, including rodent embryos. In this study, we demonstrated simultaneous electroporation of AAV donors and CRISPR/Cas9 components into embryos to create knock-in animals, and successfully generated knock-in rats carrying a gene cassette with a length of 3.0 kb using a small number of animals andin-situelectroporation. These findings indicate that this technique is an efficient high-throughput strategy for producing genetically modified rodents and may be applicable to other animal species.
The effect of motor imagery on ankle function and performance in persons with and without a lateral ankle sprain: a systematic review and meta-analysis
Authors: Siemes Luuk J.F. , Worp Maarten P. , Nieuwenhuijzen P. Henk J. A. , Stolwijk Niki M. , Pelgrim Thomas C. , Staal J. Bart 
Published: October 2022

Abstract

Background: Lateral ankle sprains are highly prevalent and result in tissue damage, impairments of muscle strength, instability and muscle activation. Up to 74% will experience ongoing symptoms after a lateral ankle sprain. Motor imagery might be supportive in rebuilding motor networks or creating new networks to restore impairments such as muscle activation and movement patterns. This systematic review was undertaken to summarize the current body of evidence.
Methods: A systematic review with meta-analysis of randomized controlled trials was conducted in healthy participants and participants with a lateral ankle sprain. Movement representation techniques (motor imagery or action observation) in isolation, or in combination with usual care were compared to controls. Any relevant variables related to (self-reported) function and performance were included in the analysis.
Results: Nine studies, six examining healthy participants and three examining participants with an acute lateral ankle sprain, were included. All studies were rated with moderate to high risk of bias overall. Quality of the motor imagery interventions differed largely between studies. The results showed a large and significant effect of motor imagery on lower leg strength (SMD 1.47, 95% CI 0.44 to 2.50). Evidence showed a non-significant effect on ankle range of motion (SMD 0.25, 95% CI -0.43 to 0.93), a non-significant on edema (SMD -1.11, 95% CI -1.60 to 3.81), a non-significant effect on the anterior reach direction of the Star Excursion Balance Test (SEBT) (SMD 0.73, 95% CI -0.62 to 2.08), the posterolateral direction (SMD 0.32, 95% CI -0.94 to 1.57), and on the posteromedial direction (SMD 0.52, 95% CI -0.07 to 1.10). The certainty of evidence for the different comparisons was very low.
Conclusions: There is a significant, positive effect for motor imagery to improve lower leg muscle strength. The certainty of evidence was however low. The effect on balance, range of motion and edema was uncertain, non-significant and of very low certainty.
Systematic review registration: PROSPERO CRD42021243258.
Appropriate concentration of botulinum toxin type A for dry eye disease treatment by injection into the medial lower eyelid. A randomized comparative study
Authors: Mekhasingharak Nattapong , Kosaiyaganonth Nattamol , Sawatdiwithayayong Jeerawat 
Published: October 2022

Abstract
This prospective, double-blind, randomized, comparative eye-to-eye interventional study aimed to determine the appropriate concentration of botulinum toxin type A for dry eye disease treatment in terms of effectiveness, complications, and cost-effectiveness.
Patients with dry eye having a similar degree in both eyes treated with non-preservative artificial tears for at least 1 month and persistent dry eye symptoms were enrolled. In each patient, a subcutaneous injection of 3.3 U of botulinum toxin type A was administered in the medial part of the randomly selected lower eyelid and 2.5 U of the same was administered to the second lower eyelid. Complete subjective and objective evaluations were performed at baseline and 2, 8, 12, and 16 weeks after intervention.
Eleven patients (mean age 64.63 ± 14.81 years) were included. Dry eye symptoms assessed by the Ocular Surface Disease Index (OSDI) score improved significantly after treatment in both the 3.3 and 2.5 U groups. Comparison of post-treatment OSDI scores, tear film break-up time (TBUT), Schirmer’s test, and modified Oxford grading scheme between the 3.3 and 2.5 U groups showed no significant difference at any time point of the study.
Conclusions: Both 3.3 and 2.5 U botulinum toxin injections improved dry eye symptoms.