bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vector‐borne disease and its relationship to hematologic abnormalities and microalbuminuria in retired racing and show‐bred greyhounds
Authors: Kidd Linda , Hamilton Helen , Stine Lisa , Qurollo Barbara , Breitschwerdt Edward B. 
Published: July 2022

AbstractBackgroundReference intervals for platelets and white blood cell (WBCs) counts are lower in greyhounds than other breeds. Proteinuria is common. Vector‐borne diseases (VBD) cause thrombocytopenia, leukopenia, and proteinuria. Racing greyhounds are commonly exposed to vectors that carry multiple organisms capable of chronically infecting clinically healthy dogs.Hypothesis/ObjectivesVector‐borne disease prevalence is higher in retired racing greyhounds than in show‐bred greyhounds. Occult infection contributes to breed‐related laboratory abnormalities.AnimalsThirty National Greyhound Association (NGA) retired racing and 28 American Kennel Club (AKC) show‐bred greyhounds.MethodsPeripheral blood was tested forAnaplasma,Babesia,Bartonella,Ehrlichia, hemotropicMycoplasma, andRickettsiaspecies using PCR. Antibodies toAnaplasma,Babesia,Bartonella,Ehrlichia, andRickettsiaspecies andBorrelia burgdorferiwere detected using immunofluorescence and ELISA assays. Complete blood counts, semiquantitative platelet estimates, and microalbuminuria concentration were determined.ResultsSeven of 30 NGA and 1/28 AKC greyhounds tested positive for ≥1 VBD (P = .05). More positive tests were documented in NGA (10/630) than in AKC dogs (1/588;P = .02). Exposure toBartonellaspecies (3/30),Babesia vogeli(2/30),Ehrlichia canis(1/30), and infection withMycoplasma hemocanis(3/30) occurred in NGA dogs. Platelet counts or estimates were >170 000/μL. White blood cell counts <4000/μL (4/28 AKC; 5/30 NGA,P > .99; 1/8 VBD positive; 8/51 VBD negative,P = .99) and microalbuminuria (10/21 AKC; 5/26 NGA,P = .06; 1/8 VBD positive; 14/25 VBD negative,P = .41) were not associated with VBD.Conclusions and Clinical ImportanceThe prevalence of thrombocytopenia andB. vogeliexposure was lower than previously documented. Larger studies investigating the health impact of multiple VBD organisms are warranted.
Are superintelligent robots entitled to human rights?
Authors: Gordon John‐Stewart 
Published: July 2022

AbstractThis paper considers relatively long‐term possibilities for the future relationship between humans and superintelligent robots (SRs). The great technological developments in fields such as artificial intelligence (AI), robotics and computer science have made it quite likely that we will see the advent of SRs towards the end of this century (or somewhat later). If SRs have a higher moral and legal status than typical adult human beings based on their greater psychological capacities, then they should also be entitled to human rights. However, even though SRs might be entitled to stronger moral and legal rights for this reason, it might nonetheless be necessary to limit their (otherwise justified) claims to avoid causing human beings to become extinct or endangered. The paper provides an argument in support of SRs' claims to human rights but also warns about the socio‐political, moral and legal implications of taking such a step.
Psychosocial and psychiatric factors preceding death by suicide: A case–control psychological autopsy study involving multiple data sources
Authors: McMahon Elaine M. , Greiner Birgit A. , Corcoran Paul , Larkin Celine , Leitao Sara , McCarthy Jacklyn , Cassidy Eugene , Bradley Colin , McAuliffe Carmel , Griffin Eve , Williamson Eileen , Foster Tom , Gallagher John , Perry Ivan J. , Kapur Nav , Arensman Ella 
Published: July 2022

AbstractBackgroundA range of factors including mental disorders and adverse life events can increase the risk of suicide. The objectives of this study were to examine psychosocial and psychiatric factors and service engagement among suicide decedents compared with living controls.MethodsA case–control study using multiple sources was conducted. Information on 132 consecutive cases of suicide was drawn from coronial files, and interviews were carried out with 35 family informants and 53 living controls. GPs completed questionnaires for 60 suicide cases and 27 controls.ResultsThe majority (83.3%) of suicide decedents had contacted a GP in the year prior to death, while 23.3% had 10 or more consultations during the year prior to death. Half of suicide decedents had a history of self‐harm. Suicide cases were significantly more likely than controls to have a psychiatric diagnosis (60% vs. 18.5%) and a depressive illness (36.7% vs. 14.8%). Over one‐quarter of suicide decedents had been treated as a psychiatric inpatient.DiscussionPrimary care providers should be supported to deliver multidisciplinary interventions to engage, assess, and treat patients at risk of suicide, targeting those who present very frequently, those with a history of self‐harm or substance misuse, and those with psychological presentations.
Subcutaneous vascular access port implantation in the axillary or femoral/external iliac vein at the time of full limb amputation in dogs
Authors: Galliano Andrea , Miraldo Diogo , Findji Laurent 
Published: July 2022

AbstractObjectiveTo report outcomes and complications after placement of a subcutaneous vascular access port (SVAP) in the jugular (jSVAP), axillary (aSVAP), and femoral or external iliac vein (fSVAP) in dogs.Study designRetrospective.MethodsMedical records from a single hospital, covering a period between September 2015 and October 2020, were reviewed to identify dogs that had an SVAP placed. Complications and outcomes for dogs who had an SVAP placed in the axillary vein, or femoral/external iliac vein during amputation for appendicular skeletal neoplasm, and in the external jugular vein were recorded and analyzed statistically.ResultsSubcutaneous vascular access ports were placed in the axillary vein in 13 dogs, femoral/external veins in 4 dogs, and in the jugular vein in 19 dogs. The SVAPs fulfilled their purpose throughout treatment in 12/13 aSVAP, 4/4 fSVAP, and 15/19 jSVAP. Dogs were followed for a median of 145.5 days (range 30‐945 days). Minor and major complications were recorded in 1/13 and 2/13 aSVAPs, 0/4 and 0/4 fSVAPs, and 3/19 and 4/19 of jSVAPs. Two dogs with jSVAPs were euthanized due to SVAP‐related complications. No difference in complication rate was detected between groups (P = .12).ConclusionNo difference in short‐term outcome was detected between implantation sites for subcutaneous vascular access ports.Clinical significanceThe axillary or femoral/external iliac veins offer alternative sites for placement of SVAP in dogs undergoing limb amputation.
HUMAN DEATH IN THEOLOGICAL ANTHROPOLOGY AND EVOLUTIONARY BIOLOGY: DISAMBIGUATING (IM)MORTALITY AS ECUMENICAL SOLUTION
Authors: van den Brink Gijsbert 
Published: July 2022

AbstractHuman death is natural from the perspective of evolutionary biology but unnatural from the vantage point of classical Christian theology. The biblical notion that death entered the world as a result of sin seems hard to square with the view that (human) death has been an integral part of the natural order all along. I suggest an ecumenical solution to this conundrum by retrieving and elaborating the Augustinian modal distinction between strong and weak immortality. It is argued on exegetical and theological grounds that the human being can best be seen as being created in a state ofposse mori et posse non mori, and that—when conceptual ambiguities in their writings are dissolved—this is what theologians as diverse as the prelates of the Council of Trent, John Calvin, Louis Berkhof, and Wolfhart Pannenberg had in mind. It is also argued that this solution is compatible with contemporary evolutionary science and can be accepted by creationists of various stripes.
Evening Caffeine Did Not Improve 100-m Swimming Time Trials Performed 60 Min Post-Ingestion or the Next Morning After Sleep
Authors: Newbury Josh W. , Saunders Bryan , Gough Lewis A. 
Published: July 2022

The potential ergogenic benefits of caffeine (CAF) are well known within the athletic community, often leading to its use in adolescent swimming cohorts to enhance their performance. However, it has previously been reported that CAF has sleep-disturbing effects, which could be detrimental to performance over consecutive days in multiday competitions. Moreover, the effects that evening CAF ingestion has on sleep, side effects, and next-day performances are yet to be researched in trained adolescents. In a double-blind, randomized, crossover design, eight national-level swimmers (age: 18 ± 1 years, height: 1.76 ± 0.06 cm, body mass [BM]: 69.4 ± 6.4 kg) ingested a capsule containing 3 mg/kg BM CAF or a placebo 60 min before an evening 100-m swimming time trial. The next morning, sleep was analyzed (Core Consensus Sleep Diary) and 100-m time trials were repeated. Side effects were analyzed via visual analog scales throughout the study. No differences were found for swimming performance (p = .911) in the evening (CAF: 59.5 ± 7.8 s, placebo: 59.9 ± 7.9 s, g = 0.06) or morning (CAF: 59.7 ± 7.7 s, placebo: 60.2 ± 7.9 s, g = 0.07). In addition, no group differences were found for any subjective side effects (e.g., anxiety: p = .468, tachycardia: p = .859, alertness: p = .959) or sleep parameters (e.g., sleep latency: p = .395, total sleep time: p = .574). These results question the use of a standardized 3 mg/kg BM CAF ingestion strategy for 100-m swimming time trials in trained adolescents, although objective measures may be needed to confirm that CAF does not affect sleep within this cohort.
Unleashing alkali feldspar: Ra/Th ages and chemical and isotopic constraints on Holocene phonolite magmatism, Canary Islands
Authors: Brown Bryce S. , Ramos Frank C. , Wolff John A. , Dorado Olaya , Martí Joan 
Published: July 2022

Abstract
Accurately dating phenocrysts in Holocene volcanic rocks poses many challenges but is critical to placing magmatic processes that occur prior to eruption into a temporal frame-work. We dated alkali feldspar (i.e., orthoclase Or10 to Or46) crystals in four young phonolites from the Teide–Pico Viejo volcanic complex, Tenerife (Spain), using (226Ra)/(230Th) isotopes. Partition coefficients of Ra (DRa) and DRa/DBa of feldspars were predicted using an approach based on the lattice strain model, which yielded crystallization ages that overlap or predate known eruption ages for the Lavas Negras (ca. 1 ka), Montaña Blanca (ca. 2 ka), Arenas Blancas (ca. 2–4 ka), and Teide H (ca. 6 ka) phonolites. Crystallization of feldspar may occur up to the time of eruption, with &gt;8 ka crystals also present, possibly suggesting extended magma differentiation times. However, feldspars yielding finite (226Ra)/(230Th) ages are mostly in equilibrium with the groundmass, unlike &gt;8 ka crystals, which were therefore identified as antecrysts/xenocrysts. The 87Sr/86Sr ratios of feldspars indicate that crystallization predated late-stage assimilation, affecting 87Sr/86Sr ratios of some melts. The (226Ra)/(230Th) ages also constrain the tempo of phonolite magma evolution on Tenerife. Integration of (226Ra)/(230Th) ages with feldspar major elements, trace elements, and isotopes provides a powerful means for investigating crystallization histories using a dominant mineral that controls the overall magmatic evolution of phonolites on thousand-year time scales.
Xenoliths reveal a hot Moho and thin lithosphere at the Cordillera-craton boundary of western Canada
Authors: Canil Dante , Russell J. Kelly 
Published: July 2022

AbstractProperties of the lithosphere control the transitions in elevation and plate deformation from hot, mobile orogenic belts to cooler, stronger cratons. The sharp, abrupt boundary of the North American Cordillera with the craton in western Canada has been suggested to be a result of recent (&lt;50 Ma) heating and delamination of the lithosphere. To test this, we queried the fine structure in the thermal history of the mantle lithosphere approaching this transition using mantle xenolith thermobarometry. The xenoliths sampled by their host lava within ~20 km of the Cordillera-craton boundary require thinner lithosphere (by 20 km) and a hotter Moho (by 200 °C) compared to those sampled 180 km away. A hot, weak lithosphere at the boundary explains a topographic low that parallels this transition for a large length of the North American Cordillera, possibly from focused heat during edge convection. The cooling pattern of geothermometers applied to the xenoliths also suggests that any delamination event producing thinner lithosphere in the orogen is unlikely to have occurred in the past 50 m.y.
Hikurangi megathrust slip behavior influenced by lateral variability in sediment subduction
Authors: Gase Andrew C. , Bangs Nathan L. , Van Avendonk Harm J.A. , Bassett Dan , Henrys Stuart A. 
Published: July 2022

AbstractSubduction megathrusts exhibit a range of slip behaviors spanning from large earthquakes to aseismic creep, yet what controls spatial variations in the dominant slip mechanism remains unresolved. We present multichannel seismic images that reveal a correlation between the lithologic homogeneity of the megathrust and its slip behavior at a subduction zone that is world renowned for its lateral slip behavior transition, the Hikurangi margin. Where the megathrust exhibits shallow slow-slip in the central Hikurangi margin, the protolith of the megathrust changes ~10 km downdip of the deformation front, transitioning from pelagic carbonates to compositionally heterogeneous volcaniclastics. At the locked southern Hikurangi segment, the megathrust forms consistently within pelagic carbonates above thickened nonvolcanic siliciclastic sediments (unit MES), which subduct beyond 75 km horizontally. The presence of the MES layer plays a key role in smoothing over rough volcanic topography and establishing a uniform spatial distribution of lithologies and frictional properties that may enable large earthquake ruptures.
Extensive and ancient feldspathic crust detected across north Hellas rim, Mars: Possible implications for primary crust formation
Authors: Phillips Michael S. , Viviano Christina E. , Moersch Jeffrey E. , Rogers A. Deanne , McSween Harry Y. , Seelos Frank P. 
Published: July 2022

Abstract
Due to its size and observable record of ancient rock, Mars is key to understanding crustal formation on planetary bodies, including Venus and Earth, which may have derived their first stable crust from mantle-overturn melting. Recent evidence that ancient martian crust contains an evolved component supports inferences of a pervasive, buried feldspathic component to the crust. With data from the Compact Reconnaissance Imaging Spectrometer for Mars (CRISM), we searched for feldspathic lithologies in pre-Noachian (older than ca. 4.1 Ga) crustal blocks uplifted by the Hellas basin-forming impact. We present evidence for ancient feldspathic rocks exposed across an ~2200 × 600 km area north of Hellas. Given their pre-Noachian age and stratigraphic position directly above putative mantle material, it is possible that these outcrops represent martian primary crust. Our discovery supports the hypothesis that there exists a pervasive, subsurface feldspathic component to the martian crust—a hypothesis that has, until now, been supported only by inferences from geodynamic data and small-scale observations.
MPEG Column: 129th MPEG Meeting in Brussels, Belgium
Authors: Timmerer Christian 
Published: July 2022

The 129th MPEG meeting concluded on January 17, 2020 in Brussels, Belgium with the following topics:
•Coded representation of immersive media - WG11 promotes Network-Based Media Processing (NBMP) to the final stage
•Coded representation of immersive media - Publication of the Technical Report on Architectures for Immersive Media
•Genomic information representation - WG11 receives answers to the joint call for proposals on genomic annotations in conjunction with ISO TC 276/WG 5
•Open font format - WG11 promotes Amendment of Open Font Format to the final stage
•High efficiency coding and media delivery in heterogeneous environments - WG11 progresses Baseline Profile for MPEG-H 3D Audio
•Multimedia content description interface - Conformance and Reference Software for Compact Descriptors for Video Analysis promoted to the final stage
JPEG column: 89th JPEG meeting
Authors: Pinheiro Antonio 
Published: July 2022

JPEG initiates standardisation of image compression based on AI.
The 89th JPEG meeting was held online from 5 to 9 October 2020.
During this meeting, multiple JPEG standardisation activities and explorations were discussed and progressed. Notably, the call for evidence on learning-based image coding was successfully completed and evidence was found that this technology promises several new functionalities while offering at the same time superior compression efficiency, beyond the state of the art. A new work item, JPEG AI, that will use learning-based image coding as core technology has been proposed, enlarging the already wide families of JPEG standards.
VQEG column: VQEG meeting Dec. 2020 (virtual/online)
Authors: Gutiérrez Jesüs , Brunnström Kjell 
Published: July 2022

Welcome to the third column on the ACM SIGMM Records from the Video Quality Experts Group (VQEG).
The last VQEG plenary meeting took place online from 14 to 18 December. Given the current circumstances, it was organized all online for the second time, with multiple sessions distributed over five to six hours each day allowing remote participation of people from different time zones. About 130 participants from 24 different countries registered to the meeting and could attend the several presentations and discussions that took place in all working groups.
This column provides an overview of this meeting, while all the information, minutes, files (including the presented slides), and video recordings from the meeting are available online in the VQEG meeting website. As highlights of interest for the SIGMM community, apart from several interesting presentations of state-of-the-art works, relevant contributions to ITU recommendations related to multimedia quality assessment were reported from various groups (e.g., on adaptive bitrate streaming services, on subjective quality assessment of 360-degree videos, on statistical analysis of quality assessments, on gaming applications, etc.), the new group on quality assessment for health applications was launched, and an interesting session on 5G use cases took place, as well as a workshop dedicated to user testing during Covid-19. In addition, new efforts have been launched related to the research on quality metrics for live media streaming applications, and to provide guidelines on implementing objective video quality metrics (ahead of PSNR) to the video compression community.
We encourage those readers interested in any of the activities going on in the working groups to check their websites and subscribe to the corresponding reflectors, to follow them and get involved.
Mixed Response to Cancer Immunotherapy is Driven by Intratumor Heterogeneity and Differential Interlesion Immune Infiltration
Authors: Morinaga Takao , Inozume Takashi , Kawazu Masahito , Ueda Youki , Sax Nicolas , Yamashita Kazuo , Kawashima Shusuke , Nagasaki Joji , Ueno Toshihide , Lin Jason , Ohara Yuuki , Kuwata Takeshi , Yukami Hiroki , Kawazoe Akihito , Shitara Kohei , Honobe-Tabuchi Akiko , Ohnuma Takehiro , Kawamura Tatsuyoshi , Umeda Yoshiyasu , Kawahara Yu , Nakamura Yasuhiro , Kiniwa Yukiko , Morita Ayako , Ichihara Eiki , Kiura Katsuyuki , Enokida Tomohiro , Tahara Makoto , Hasegawa Yoshinori , Mano Hiroyuki , Suzuki Yutaka , Nishikawa Hiroyoshi , Togashi Yosuke 
Published: July 2022

Some patients experience mixed response to immunotherapy, whose biological mechanisms and clinical impact have been obscure. We obtained two tumor samples from lymph node (LN) metastatic lesions in a same patient. Whole exome sequencing for the both tumors and single-cell sequencing for the both tumor-infiltrating lymphocytes (TIL) demonstrated a significant difference in tumor clonality and TILs’ characteristics, especially exhausted T-cell clonotypes, although a close relationship between the tumor cell and T-cell clones were observed as a response of an overlapped exhausted T-cell clone to an overlapped neoantigen. To mimic the clinical setting, we generated a mouse model of several clones from a same tumor cell line. Similarly, differential tumor clones harbored distinct TILs, and one responded to programmed cell death protein 1 (PD-1) blockade but the other did not in this model. We further conducted cohort study (n = 503) treated with PD-1 blockade monotherapies to investigate the outcome of mixed response. Patients with mixed responses to PD-1 blockade had a poor prognosis in our cohort. Particularly, there were significant differences in both tumor and T-cell clones between the primary and LN lesions in a patient who experienced tumor response to anti–PD-1 mAb followed by disease progression in only LN metastasis. Our results underscore that intertumoral heterogeneity alters characteristics of TILs even in the same patient, leading to mixed response to immunotherapy and significant difference in the outcome.Significance:Several patients experience mixed responses to immunotherapies, but the biological mechanisms and clinical significance remain unclear. Our results from clinical and mouse studies underscore that intertumoral heterogeneity alters characteristics of TILs even in the same patient, leading to mixed response to immunotherapy and significant difference in the outcome.
Dietary Nonstarch Polysaccharide Intake and Risk of Colorectal Cancer: Findings from the Singapore Chinese Health Study
Authors: Yu Yi-Chuan , Paragomi Pedram , Jin Aizhen , Wang Renwei , Schoen Robert E. , Koh Woon-Puay , Yuan Jian-Min , Luu Hung N. 
Published: July 2022

Dietary fiber or nonstarch polysaccharides (NSP) may provide protection from colorectal cancer development. Epidemiologic studies on the association between dietary fiber and colorectal cancer is inconsistent are limited on NSP as a modifiable risk factor. Using the Singapore Chinese Health Study, a population-based prospective cohort of 61,321 cancer-free middle-aged or older Chinese Singaporeans, we examined the association between dietary fiber and NSP intakes and colorectal cancer risk. Fiber and NSP intakes at baseline were obtained using a validated semiquantitative food frequency questionnaire coupled with the Singapore Food Composition Database. Cox proportional hazard regression model was used to estimate the HRs and respective 95% confidence intervals (CI) for colorectal cancer associated with dietary fiber and NSP intakes after adjusting for potential confounders. After an average of 17.5 years of follow-up, 2,140 participants developed colorectal cancer. NSP was inversely associated with the risk of colorectal cancer in a dose-dependent manner, whereas dietary fiber was not associated with risk of colorectal cancer overall or histologic subtypes. The multivariable-adjusted HRs (95% CIs) of colorectal cancer for quartiles 2, 3, and 4 of dietary NSP intake were 0.99 (0.88–1.11), 0.98 (0.87–1.11), and 0.84 (0.73–0.95), respectively, compared with the lowest quartile (Ptrend = 0.006). This inverse association was more apparent for colon cancer (HRQ4 vs. Q1 = 0.79, 95% CI: 0.67–0.93, Ptrend = 0.003) than rectal cancer (HR Q4 vs. Q1 = 0.92, 95% CI: 0.74–1.13, Ptrend = 0.53). Our findings suggested that dietary NSP but not fiber is associated with a reduced risk of colon cancer in Chinese Singaporeans.Significance:NSPs may be beneficial for colorectal cancer primary prevention.