bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protein requirements of hair sheep raised in warm areas: a multi-study approach
Authors: Herbster Caio Julio Lima , de Sousa Mendes Marcilio , de Oliveira Alessandra Pinto , Marcondes Marcos Inácio , Rodrigues João Paulo Pacheco , da Silva Luciano Pinheiro , Santos Stefanie Alvarenga , de Almeida Teixeira Izabelle Auxiliadora Molina , Azevêdo José Augusto Gomes , Pereira Elzania Sales 
Published: October 2022

AbstractThe protein requirements of hair sheep are a key factor in increasing profitability and decreasing the environmental impacts of nitrogen excretion. The objective of this study was to evaluate the protein requirements of hair sheep. A database with 382 individual records (269 intact and 113 castrated males) comprising information from 11 studies was used. The studies provided different levels of metabolisable protein intake (MPI) and of N retention, allowing the development of equations to predict the net protein (NP) and the metabolisable protein (MP) requirements. The efficiency of MP use for gain (kpg) was calculated using the equation of daily protein retained against daily MPI above maintenance. The efficiency of MP use for maintenance (kpm) was computed as the ratio between the NP for maintenance (NPm) and the MP for maintenance (MPm). The NPm (1.32 g/kg0.75EBW) did not differ between sex. Thekpmwas 0.34, and thekpgwas 0.25. The MPm estimated was 3.21 g/kg0.75BW. Sex affects the protein requirements for gain (NPg). The protein requirements of hair sheep differ from those recommended by feeding systems for sheep. The equations provided herein may improve the optimisation of protein nutrition of sheep, thereby minimising the environmental impacts of sheep production.
In situ crystallization of non-cotectic and foliated igneous rocks on a magma chamber floor
Authors: Kruger Willem , Latypov Rais 
Published: October 2022

AbstractLayered mafic intrusions commonly contain non-cotectic, foliated igneous rocks that are traditionally attributed to processes involving settling, transport, and redeposition of crystals. Here we examine the chemistry of magnetitite layers of the Bushveld Complex using a portable XRF spectrometer on drill core and dissolution ICP-MS analysis on pure magnetite separates. While magnetitites contain foliated plagioclase grains in non-cotectic proportions, the magnetite is characterized by a regular upwards-depletion of Cr which is best explained by in situ crystallization. We suggest that plagioclase nucleation in thin residual compositional boundary layers atop a solidification front causes in situ growth of plagioclase in proportions much lower (<10%) than those expected from cotectic crystallization (±85%). Crystallization in such a boundary layer also favours lateral growth of the plagioclase, producing the foliation. We suggest that some non-cotectic, foliated rocks that are commonly interpreted to arise from gravity-induced sedimentary processes may instead be produced by in situ crystallization.
Considerations for the Over-the-Counter Hearing Aid Delivery Model
Authors: Sheffield Sterling W. , Jacobs Molly , Ellis Charles 
Published: October 2022

Purpose:
The U.S. Food and Drug Administration (FDA) introduced the Reauthorization Act that included provisions for self-fitting hearing aids to be sold over the counter in 2017, and in August 2022, the FDA published the final regulatory guidelines for the safety and efficacy of the devices. The American Speech-Language-Hearing Association and other professional organizations provided feedback to proposed regulations before they were finalized. This article updates hearing health care and related professionals on the history and state of hearing aid delivery models and addresses considerations for clinicians, physicians, and consumers.

Conclusions:
Direct-to-consumer (DTC) hearing devices can vary largely in quality and performance capability. Some might meet the finalized FDA safety and performance criteria for over-the-counter hearing aids and be able to provide accurate amplification for mild-to-moderate hearing loss but most likely cannot meet the needs of more severe hearing losses, for which they are not approved. Other DTC devices may not meet the FDA criteria and may not provide accurate amplification for many degrees of hearing loss. It is important that these devices are correctly advertised and marketed to those with hearing loss no worse than mild to moderate. Consumers and health care providers also need to know how to identify quality devices that can meet patients' hearing needs. The DTC hearing devices may be difficult to program; thus, manufacturers should provide support for consumers to properly fit these devices. Lastly, hearing health care professionals should take the time to verify that any current and soon-to-come DTC hearing devices can be useful for a given patient population.
A makespan minimization problem for versatile developers in the game industry
Authors: Su Chung-Ho , Wang Jen-Ya 
Published: October 2022

Today, the development of a modern video game draws upon multiple areas of expertise. Moreover, its development cost could be as high as tens of millions of dollars. Consequently, we should carefully schedule its jobs so as not to increase the total cost. However, project leaders traditionally treat developers alike or even schedule all the jobs manually. In this study, we consider a versatile-developer scheduling problem. The objective is to minimize the makespan of a game project. We propose a branch-and-bound algorithm (B&B) to generate the optimal schedules for small problem instances. On the other hand, an imperialist competitive algorithm (ICA) is proposed to obtain approximate schedules for large problem instances. Lastly, computational experiments are conducted to show the performances of both algorithms. When the problem size is small (e.g., n ≤ 12), B&B can generate the optimal schedules within 5 s. For some large problem instances (e.g., n = 600), near-optimal schedules can be obtained by ICA within 10 min. The final results imply that both algorithms converge quickly and are of high solution quality.
Effects of Chronic Oral Administration of Midazolam on Memory and
Circadian Rhythms in Rats
Authors: Murphy Helen M. , Kalinina Anastasiya I. , Wideman Cyrilla H. 
Published: October 2022

AbstractStudies have shown the ability of benzodiazepine drugs to cause memory loss in
animals and humans. Midazolam is a benzodiazepine commonly administered
intravenously during surgical procedures because it reacts rapidly, causes
anterograde amnesia, and has few side effects. It has also been used in
palliative medicine where, among others, an oral route has been employed for
chronic administration of the drug. The current study evaluated the effects of
chronic orally administered midazolam on spatial working memory and procedural
memory in control and experimental female rats over a three-week experimental
period utilizing the Morris water maze. Sample and test run times to a submerged
platform in the maze were recorded daily. In addition, activity wheels attached
to each cage were employed to monitor daily circadian activity of the animals.
Spatial working memory was not impaired in either group. However, procedural
memory amnesia occurred in animals receiving the drug indicative of a
consolidation or retrieval problem. Concerning circadian rhythms, a phase-shift
was noted in experimental animals possibly indicating that time of day of drug
administration is important. The findings of the present study could shed
insight into altered reactions observed in humans who have received midazolam as
a component of treatment in palliative medicine.
EUS-guided endoscopic internal drainage with lumen-apposing metal stent for symptomatic hepatic cysts: a case series (with video)
Authors: DʼErrico Francesca , Derhy Serge , Fazi Maurizio , Memeo Riccardo , Decembrino Francesco , De Palma Giovanni D. , Donatelli Gianfranco 
Published: October 2022

Abstract
Background and study aims Simple hepatic cysts (SHCs) are usually asymptomatic and detected incidentally. However, larger cysts may present with clinical signs and require treatment such as percutaneous aspiration or surgery with non negligeable rate of recurrence. We report a series of 13 consecutive patients who underwent EUS-guided lumen-apposing metal stent (LAMS) drainage of SHCs of the right and left liver.
Patients and methods Nine men and four women, average age 71.9 years, underwent EUS-guided LAMS cyst drainage because of significant symptoms. At 1 month, LAMS was exchanged for a double pigtail stent (DPS), which was left in place for 3 months. Nine of the SHCs were located in the right liver and four in the left. The average diameter was 22.2 cm.
Results Thirteen LAMS were successful delivered in all patients. However only 12 of 13 (92.3 %) remained in place. In one case, the LAMS slipped out immediately and was promptly removed and the cyst treated percutaneously. One of 12 patients experienced bleeding, which was treated conservatively. In seven patients, the LAMS was exchanged for a DPS; in the other five, it was successfully left in place until the patients died, given their comorbidities. At 10.5 months of follow-up, none of the SHCs had recurred.
Conclusions EUS-guided LAMS drainage permits treatment of symptomatic SHCs without recurrence and with few adverse events. Comparative studies are needed to consider this approach as first intention.
Validation studies on migraine diagnostic tools for use in nonclinical settings: a systematic review
Authors: Wei Du , Wong Li Ping , Loganathan Tharani , Tang Rong-Rui , Chang Yue , Zhou Han-Ni , Kaabar Mohammed K. A. 
Published: October 2022

Abstract
Background Migraine underdiagnosis and undertreatment are so widespread, that hence is essential to diagnose migraine sufferers in nonclinical settings. A systematic review of validation studies on migraine diagnostic tools applicable to nonclinical settings can help researchers and practitioners in tool selection decisions.
Objective To systematically review and critically assess published validation studies on migraine diagnostic tools for use in nonclinical settings, as well as to describe their diagnostic performance.
Methods A multidisciplinary workgroup followed transparent and systematic procedures to collaborate on this work. PubMed, Medline, and Web of Science were searched for studies up to January 17, 2022. The QUADAS-2 was employed to assess methodological quality, and the quality thresholds adopted by the Global Burden Disease study were used to tail signaling questions.
Results From 7,214 articles identified, a total of 27 studies examining 19 tools were eligible for inclusion. There has been no high-quality evidence to support any tool for use of migraine diagnosis in nonclinical settings. The diagnostic accuracy of the ID-migraine, structured headache and HARDSHIP questionnaires have been supported by moderate-quality evidence, with sensitivity and specificity above 70%. Of them, the HARDSHIP questionnaire has been the most extensively validated. The remaining 16 tools have provided poor-quality evidence for migraine diagnosis in nonclinical populations.
Conclusions Up till now, the HARDSHIP questionnaire is the optimal choice for diagnosing migraine in nonclinical settings, with satisfactory diagnostic accuracy supported by moderate methodological quality. This work reveals the crucial next step, which is further high-quality validation studies in diverse nonclinical population groups.
Differences in Surgery Classification and Indications for Peripartum Hysterectomy at a Major Academic Institution
Authors: Meeks Monica , Voegtline Kristin , Vaught Arthur J. , Lawson Shari M. 
Published: October 2022

Objective Peripartum hysterectomy is associated with increased morbidity and mortality relative to elective gynecologic hysterectomy and its incidence has grown with the rising cesarean delivery rate. We sought to understand indications and perioperative outcomes for peripartum hysterectomy at our academic institution and to evaluate differences among racial/ethnic groups.
Study Design We performed a retrospective chart review of women at a tertiary care center who underwent delivery of a newborn and had a peripartum hysterectomy during the same admission between 2008 and 2018. Demographic, clinical, and socioeconomic characteristics of patients were compared with respect to patient's race/ethnic group.
Results A total of 112 hysterectomies were included in our study. White women undergoing peripartum hysterectomy were more likely to have had an elective/anticipated peripartum hysterectomy (vs. a nonelective/emergent peripartum hysterectomy) than Black women. There were racial differences detected in the indication for peripartum hysterectomy; White women were more likely to have abnormal placentation (75 vs. 54% in Black women, p = 0.036), whereas Black women were more likely to present with postpartum hemorrhage (27 vs. 2%, p = 0.002). Black women were also more likely to undergo reoperation after peripartum hysterectomy (15 vs. 2% in White women, p = 0.048). There were no differences in any other perioperative outcomes including blood transfusion, accidental laceration, and 30-day readmission.
Conclusion Differences exist among elective versus nonelective peripartum hysterectomy by race/ethnicity and in indications for peripartum hysterectomy by race/ethnicity. Further investigation should be performed to determine whether the differences identified are due to disparate management of atony/postpartum hemorrhage or inequitable referral patterns for suspected abnormal placentation by race/ethnicity.
Key Points
A Meta-Analysis of Migraine Treated with Banxia Baizhu Tianma Decoction
Authors: Chen Xueyan , Liu Zheyan , Zhang Jie , Chen Juanjuan , Qin Xiude , Jiang Feng 
Published: October 2022

Abstract
Objective Our objective was to systematically evaluate the efficacy and safety of Banxia Baizhu Tianma decoction in the treatment of migraine.
Methods The databases of China National Knowledge Infrastructure, VIP, WanFang, Chinese Biomedical Databases, PubMed, and EMbase were searched by computer, and randomized controlled trials that met the inclusion criteria were retrieved. The Cochrane bias risk assessment tool was used to evaluate the quality of the included studies. RevMan 5.3 software was used to conduct meta quantitative analysis of the included studies.
Results A total of 19 studies were included, with a total sample size of 1,635 cases, 821 cases in the treatment group and 814 cases in the control group. The results of meta-analysis showed that (1) the clinical effective rate of the single use of Banxia Baizhu Tianma decoction or western medicine combined with Banxia Baizhu Tianma decoction in treating migraine was better than that of western medicine alone (p < 0.001); (2) the improvement in cumulative number and days of vertigo in the treatment of migraine with Banxia Baizhu Tianma decoction was observed in the control group (p < 0.001). TSA results showed that Z-curve passed both the traditional threshold and Trial sequential analysis (TSA) threshold. In terms of adverse reactions, 55 cases were reported, including 12 cases in the treatment group and 43 cases in the control group, and no serious adverse reactions were found.
Conclusion Compared with the single use of western medicine therapy, the combination of Banxia Baizhu Tianma decoction and western medicine or the single use of Banxia Baizhu Tianma decoction could better improve the effective rate and showed good safety and low incidence of adverse reactions.
The Mechanism of Action of Qihuang Jiangtang Capsule in the Treatment of Type 2 Diabetes Based on Network Pharmacology and Molecular Docking Technology
Authors: Ji Mengmeng , Yu Yanan , Wu Jiarui , Liu Jun , Jiang Yanhua , Jing Zhiwei 
Published: October 2022

Abstract
Objective Our objective was to investigate the potential mechanism of action of Qihuang Jiangtang capsule (QHJTC) in the treatment of type 2 diabetes mellitus (T2DM) through network pharmacology and molecular docking.
Methods The active components of materia medica in the formula of QHJTC were searched on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and Encyclopedia of Traditional Chinese Medicine. The targets related to the active components were obtained via PubChem database. The targets related to T2DM were retrieved through the GeneCards database. The targets corresponding to the active components and diabetes mellitus were uploaded to the Venn diagrams website to get the Venn diagram, and the intersecting targets were the potential targets of QHJTC in treating T2DM. The active components and potential targets were imported into Cytoscape 3.7.2 software to construct the active component–potential target network, and the key compounds and targets were screened by the Network Analyzer module in the Tools module. The potential targets were imported into the STRING database to obtain the interaction relationships, so as to analyze and construct the protein–protein interaction (PPI) network by Cytoscape 3.7.2 software. The intersecting targets were introduced into Metascape for gene ontology (GO) functional enrichment analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis. The top 20 signaling pathways obtained by the KEGG pathway enrichment analysis and the related targets and the corresponding targets were analyzed by using Cytoscape 3.7.2 software to construct the “active component–important target-key pathway network ” for the intervention of T2DM with QHJTC. The molecular docking of active components and core targets was performed with AutoDock software.
Results A total of 237 active components and 281 related targets were obtained from QHJTC, as well as 1 362 T2DM targets and 155 potential targets of QHJTC in treating T2DM. There were 32 key components and 49 key targets identified by the active component–potential target network topology analysis. There were 471 terms obtained from GO functional enrichment analysis, among which 248 related to biological processes, 125 related to molecular functions, and 98 related to cellular components. There were 299 signaling pathways obtained from KEGG pathway enrichment analysis. The active components of QHJTC were found spontaneously binding to the core targets.
Conclusions QHJTC can treat T2DM through multi-components, multi-targets, and multi-pathways.
New Clinical Application of Chaihu Decoction
Authors: Huang Bo , Liu Yingfeng , Lyu Yajing 
Published: October 2022

AbstractThe classified prescriptions from Chaihu decoction have been widely used in ancient and modern times. In spite of many previous research studies, the extensiveness and diversity of their applications have not been systematically studied. The author applied Chaihu Wendan decoction to treat phlegm and qi stagnation in the middle energizer, applied Chaihu Guizhi decoction to treat simultaneous disease of Shaoyang and Taiyang, applied Chaihu Xiexin decoction to treat simultaneous disease of the spleen, stomach, liver, and gallbladder, applied Chaihu Ermiao powder to treat simultaneous disease of hand Shaoyang and foot Taiyin, applied Chaihu Erchen decoction to treat simultaneous disease of Shaoyang and Taiyin, applied Chailing decoction to treat simultaneous disease of hand Shaoyin and foot Taiyang, applied Chaihu Guizhi Ganjiang decoction to treat Shaoyang and Taiyin cold fluid retention and heat stagnation syndrome of Shaoyang complicated with Taiyin, applied Chaihu Xingren decoction to treat simultaneous disease of hand Shaoyang and hand Taiyin, applied Chaihu Sanren decoction to treat the disease caused by damp-heat stagnation in the hand Shaoyang and the foot Taiyin, and applied Chaihu Ganlu Xiaodu pellet to treat the diseases of hand Shaoyang and foot Yangming. The effects were all remarkable.
Waterwheel-inspired high-performance hybrid electromagnetic-triboelectric nanogenerators based on fluid pipeline energy harvesting for power supply systems and data monitoring
Authors: Lian Mengying , Sun Jiaxin , Jiang Dawei , Xu Miaojun , Wu Zijian , Bin Xu Ben , Algadi Hassan , Huang Mina , Guo Zhanhu 
Published: October 2022

Abstract
In this work, a self-powered system based on a triboelectric-electromagnetic hybrid pipeline energy harvesting module is demonstrated. Rabbit fur and poly tetra fluoroethylene (PTFE) are used as triboelectric electrodes to fabricate disk-type soft-contact triboelectric nanogenerators (TENGs) instead of traditional direct-contact TENGs to collect the mechanical energy of water flow and convert it into electrical energy. This design has a stable electrical output and gives an improved durability. Its simple fabrication process enables excellent potential for practical applications in industry. In addition, the hybridization of electromagnetic generator module and TENGs module to form a triboelectric-electromagnetic hybrid nanogenerator (TEHNG) can improve the electrical output performance, especially the current output. TEHNG cannot only power small electronic devices, such as lighting systems, but also collect independent fluid energy and monitor data signals simultaneously in harsh environments, such as fluid energy harvesting in industrial production pipelines and temperature and humidity in fluid environments. This work provides an efficient strategy to harvest multiple energies simultaneously, significantly increasing the yield and promoting the application of TENGs in engineering.
Gravitational analysis of Einstein-non-linear-Maxwell-Yukawa black hole under the effect of Newman-Janis algorithm
Authors: Babar Rimsha , Asgher Muhammad , Ali Riasat 
Published: October 2022

Abstract
In this paper, we analyze the rotating Einstein-non-linear-Maxwell-Yukawa black hole solution by Janis-Newman algorithmic rule and complex calculations. We investigate the basic properties (i.e., Hawking radiation) for the corresponding black hole solution. From the horizon structure of the black hole, we discuss the graphical behavior of Hawking temperature T

H
and analyze the effects of spin parameter (appears due to Newman-Janis approach) on the T

H
of black hole. Furthermore, we investigate the corrected temperature for rotating Einstein-non-linear-Maxwell-Yukawa black hole by using the vector particles tunneling strategy which is based on Hamilton-Jacobi method. We additionally study the graphical explanation of corrected T

H
through outer horizon to investigate the physical and stable conditions of black hole. Finally, we compute the corrected entropy and check that the effect of charged, rotation and gravity on entropy.
Searching for axion-like particles through CMB birefringence from string-wall networks
Authors: Jain Mudit , Hagimoto Ray , Long Andrew J. , Amin Mustafa A. 
Published: October 2022

Abstract
Axion-like particles (ALPs) can form a network of cosmic strings and domain walls that survives after recombination and leads to anisotropic birefringence of the cosmic microwave background (CMB). In addition to studying cosmic strings, we clarify and emphasize how the formation of ALP-field domain walls impacts the cosmic birefringence signal; these observations provide a unique way of probing ALPs with masses in the range 3H
0 ≲ ma
≲ 3H
cmb. Using measurements of CMB birefringence from several telescopes, we find no evidence for axion-defect-induced anisotropic birefringence of the CMB. We extract constraints on the model parameters that include the ALP mass ma
, ALP-photon coupling 𝒜 ∝ gaγγ

fa
, the domain wall number N
dw, and parameters characterizing the abundance and size of defects in the string-wall network. Considering also recent evidence for isotropic CMB birefringence, we find it difficult to accommodate this with the non-detection of anisotropic birefringence under the assumption that the signal is generated by an ALP defect network.