bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of lysophosphatidic acid on sling and clasp fibers of the human lower esophageal sphincter
Authors: Feng Yong , Wei Wei , Chen Liang , Liu Jun-Feng 
Published: August 2022

Background: This study aims to explore the role of lysophosphatidic acid receptors in the regulation mechanisms of contraction and relaxation of human lower esophageal sphincter.
Methods: Between July 2015 and March 2016, muscle strips were collected from a total of 30 patients (19 males, 11 females; mean age: 62±9.9 years; range, 52 to 68 years) who underwent an esophagectomy for mid?third esophageal carcinomas. The specimens were maintained in oxygenated Krebs solution. Muscle tension measurement technique in vitro was used to examine the effects of non-selective lysophosphatidic acid receptors agonists and antagonists, as well as selective lysophosphatidic acid receptors agonists on the clasp and sling fibers of human lower esophageal sphincter.
Results: The non-selective dopamine receptor agonist lysophosphatidic acid induced the contraction of the clasp and sling fibers of the human lower esophageal sphincter. The response induced by nonselective lysophosphatidic acid receptor agonist was inhibited completely by non-selective lysophosphatidic acid receptor antagonist. The selective lysophosphatidic acid 1 and 2 receptor agonist and the selective lysophosphatidic acid 3 receptor agonist induced a concentration-dependent contractile response of the clasp and sling fibers of the human lower esophageal sphincter. There was no significant difference in contraction rates between the clasp and sling fibers (p>0.05).
Conclusion: This study indicates that lysophosphatidic acid regulates the lower esophageal sphincter is through its receptor; the lysophosphatidic acid receptors may be involved in the contractile response of the human lower esophageal sphincter.
LITERATURE STUDY OF ANTIBACTERIAL ASSAY OF AVERRHOA BILIMBI L. AGAINST GRAM POSITIVE BACTERIA
Authors: Sari Erwika Dwika , Kosman Rachmat , Herwin Herwin 
Published: August 2022

Averrhoa bilimbi L. is one of the traditional medicines that people empirically use as medicine to treat various diseases such as cough, diabetes, rheumatism, mumps, canker sores, toothache, bleeding gums, acne, diarrhea to high blood pressure. The research aimed to determine the antibacterial activity of Averrhoa bilimbi L. against gram-positive bacteria. This research applied a literature study method in which the references were obtained from 3 data bases, namely google scholar, pubmed and mdpi, then selected journals that metthe criteria in the literature study. From the journal exploration, 7 journals were obtained. Then the antibacterial activity of Averrhoa bilimbi L. against gram-positive bacteria was observed. The results confirmed that the fruit and leaves of Averrhoa bilimbi L. had an antibacterial activity against Staphylococcus aureus, Streptococcus mutans, Staphylococcus epidermidis, and Propionibacterium acnes due to the presence of secondary metabolites, namely saponins, tannins, alkaloids and flavonoid.
INFLUENCE OF LIQUIDITY AND PROFITABILITY ON COMPANY VALUE IN THE MANUFACTURING SECTOR LISTED ON THE INDONESIA STOCK EXCHANGE (IDX) 2015-2019
Authors: Hikmat Imat , Agustina Dwian , Haquei Fitria 
Published: August 2022

This research was conducted on manufacturing sector companies listed on the Indonesia Stock Exchange (IDX). The purpose of this study is to find out the significant effect of the liquidity variable with the Current Ratio (CR) proxy and the profitability variable with the Return on Assets (ROA) proxy partially and simultaneously on firm value using the Price to Book Value (PBV) measuring instrument. The population in this study amounted to 150 manufacturing sector companies listed on the Indonesia Stock Exchange (IDX), using a purposive sampling technique which in the end, only nine companies were taken as samples. This study uses secondary data in annual financial statements from 2015 to 2019 by testing the hypothesis using multiple linear regression. The results of the partial study (T-Test) show that the liquidity variable has a sig value. 0.005 < 0.050 and the value of T count > T table (-2,985 > 2.018) has a significant negative effect on firm value. while profitability has a sig value. 0.410 > 0.050 and the value of T count < T table (0.833 < 2.018) has no significant effect on firm value. And the results of simultaneous research (F-Test) M has a value of F count and F table, namely (5.515 > 3.220) and a significance value (0.007 < 0.050), indicating that liquidity and profitability together have a significant effect on firm value.

Keywords: Liquidity; Profitability; Firm Value.
EFFECT OF PRICING AND PACKAGING ON CONSUMER PURCHASE DECISIONS AT MR. B IN THE CITY OF SERANG.
Authors: Bahrudin Udin , Sembiring Edy Suranta Karina 
Published: August 2022

The purpose of the study was to determine the effect of pricing on consumer purchasing decisions, to determine the effect of packaging on consumer purchasing decisions and to jointly determine the effect of pricing and packaging on consumer purchasing decisions. B in Serang City. This study uses quantitative research methods, data collection using research instruments, quantitative/statistical data analysis with the aim of testing the established hypothesis. The population in this study are consumers or visitors to Mr. Shop. B in Serang City who had made a purchase at Mr. Shop. B in Serang City. Based on the results of testing hypothesis 1, it shows that pricing has a significant effect on consumer purchasing decisions. B in Serang City, in this case, if the price fixing increases, the consumer's purchasing decisions will increase. The results of testing hypothesis 2 show that packaging has a significant effect on consumer purchasing decisions. B in Serang City, in this case, if the packaging increases, the consumer's purchasing decisions will increase. The results of the submission of hypothesis 3 show that pricing and packaging have a significant effect on consumer purchasing decisions. B in Serang City, this is if the pricing and packaging increase, the consumer's purchasing decisions will increase.

Keywords: Pricing, Packaging and Consumer, Purchase Decisions
INFLUENCE OF THE DEMONSTRATION METHOD OF MATHEMATICS LEARNING OUTCOMES DURING THE ONLINE PENDEMIC IN GRADE IV SDN CILAKU SERANG CITY
Authors: Gunardi Ari , Nursehah Uvia , Hikmawan Aditya 
Published: August 2022

ABSTRACT
This research conducted to find out the effect of the demonstration method on the results of learning mathematics during the online pandemic in the fourth grade of SDN Cilaku, Serang City. The type of research used by the researcher is experimental research, the experimental method with the type of true experiment. The form taken is Pretest-Posttest Control Group Design. The instrument used in this study was a test in the form of 30 multiple choice questions as well as student and teacher documentation. The student population studied in this study were 81 students with 40 students in class IV A and 41 students in IV B. Based on the results of the study, it can be seen that the results of cognitive learning in Mathematics before being treated using the demonstration method and tested using a pretest, the average value is 46.76. This value is included in the low category and the majority of students' pretest learning outcomes are 39 students in the low group or can be presented to 45.50%, which is possible because children are less interested in the usual lecture method used by the teacher. Meanwhile, after being treated using the demonstration method and doing a posttest, it can be seen that the average value changed to 73.82, and this is included in the fairly high category. The largest value is 100 (very high category). And the lowest value is 45.00 (very low category). The majority of students' posttest learning outcomes are in the high category, which is 45% or as many as 19 students. So it can be concluded that this research has the effect of using the demonstration method on learning outcomes of Mathematics in the material of flat shapes in fourth grade students of SDN Cilaku, Serang City because it has an increase in the value of learning outcomes as much as 70%.

Keywords: Demonstration method, Learning outcomes
Delineation and Mapping of Groundwater Quality in Chengalpattu District of Tamil Nadu, India
Authors: Hemavarshini M. P. , Janaki D. , Baskar M. , Radhika S. , Jagadeeswaran R. 
Published: August 2022

Groundwater is a major natural source of water supply all around the world. It's utilised for irrigation, industry, and even household purposes. The quality of groundwater is important for irrigation. Irrigation water quality plays a critical role in long-term soil productivity. To assess the quality of the groundwater, 149 samples were taken in May 2022 from the coastal blocks of the Chengalpattu district: Chithamur (42), Lathur (37), Thirukalukundram (31), and Thiruporur (39). The samples were analysed in accordance with the appropriate protocol. The study revealed that the coastline blocks pH ranges from 8.92 to 7.52 and their EC ranges from 11.50 to 0.13 dS m-1. The Sodium Absorption Ratio (SAR) ranges from 20.00 to -6.80, while the Residual Sodium Carbonate (RSC) ranges from 14.77 to 0.26 meq/L. The Chengalpattu district has a high concentration of alkali water, according to CSSRI, Karnal classification. Among the coastal blocks, the Thiruporur block contains more alkali water compared to other coastal blocks (46%).
Effect of Laparoscopic Ovarian Cystectomy of Endometriotic and Non-Endometriotic Cysts on Ovarian Volume, Ovarian Reserve and Ovarian Doppler Velocimetry
Authors: Elagha Ahmed Salah Abo , Dawood Aymn Shehata , Elshorbagy Shahenaz Hamdy , Ghareeb Ashraf Elmohamady 
Published: August 2022

Background: Laparoscopic ovarian cystectomy (LOC) is one of the most often performed and simplest gynaecological procedures. The aim of this study was to evaluate the change in ovarian reserve, ovarian volume and ovarian Doppler velocimetry after LOC, between endometrioma patients and other benign ovarian cysts.
Methods: Eighty participants were enrolled in this prospective cohort research. Aged 18-40 years suffering from unilateral ovarian cysts. Patients were classified into two equal groups: group I: unilateral (endometriotic cyst), and group II: unilateral (non-endometriotic cyst) each group was subdivided into 2 equal subgroups. Group I: subgroup A: stripping and subgroup B: cauterization. Group II: subgroup A: dermoid cysts and subgroup B: simple serous cyst.
Results: AMH (antimullerian hormone) post operation and after 3 months were significantly higher in stripping than cauterization subgroups. AMH post operation and after 3 months, AFC (unilateral antral follicle counts) after operation and reduction in AFC were significantly lower in stripping subgroup in endometrioma than dermoid subgroup in non-endometrioma. AFC before operation, reduction in AMH post 3 months, reduction in AFC and reduction in ovarian volume were significantly lower in dermoid than simple cyst subgroups in non- endometrioma group. AFC after operation was significantly higher in dermoid than simple cyst subgroups in non- endometrioma group.
Conclusions: AMH was higher in stripping subgroup than cauterization subgroup in endometrioma group post-operatively. AFC was higher in simple subgroup than dermoid subgroup in non-endometrioma group before operation, but no significant difference was noted after operation.
Evaluation of YKL-40 as a Biomarker of Inflammation and Atherosclerosis in Chronic Kidney Disease Patients
Authors: El-Ghorab Omar Ali Abdel Naby , Elshafey Mohamed Hassan Rashad , Negm Manal Saad Ahmed , Elkhateeb Mervat Abdel-Hameed Taha 
Published: August 2022

Background: Chronic kidney disease (CKD) has been recognized as a leading public health problem worldwide. In Egypt, CKD approximately affects 13% of the adult population, resulting in significant morbidity, mortality, and health care costs. Patients with advanced CKD (stage 3 or more) experience a high rate of cardiovascular complications compared to earlier stages of CKD.
Objective: To evaluate serum YKL-40 levels in patients with CKD to assess its value as a biomarker of inflammation and its correlation with carotid intima-media thickness (CIMT) as a predictor for early atherosclerosis.
Patients and Methods: The present study was conducted on fifty subjects divided into 2 groups: group I includes 25 patients with CKD (from stage 1 to stage 5 "pre-dialysis") and group II (control group) includes 25 healthy volunteers. The patients were recruited from Internal Medicine Department and Nephrology Unit, Tanta university hospitals in the period between," August 2020 to September 2021 ".
Results: In our study, YKL-40 levels were significantly high in CKD patients(P=0.001). As regards CIMT measurements for the studied cases its median value was 0.90 and1 mm for the right and left carotid respectively. On the other hand, CIMT measurements for the studied volunteers were within the normal range with statistically significant differences between both groups (p=0.001). There is a positive significant correlation between the serum YKL-40 level from the studied cases with each of triglycerides, serum urea, serum creatinine, CRP, ESR, R CIMT, and L CIMT. Systolic blood pressure, triglyceride, cholesterol, LDL, serum urea, serum creatine, e-GFR, ESR, CRP, and YKL-40 were found to be independent predictors for CIMT (P<0.05). Serum YKL-40 is a highly sensitive predictor of atherosclerosis in CKD and its specificity is 74% in CKD cases.
Conclusion: Serum YKL-40 was significantly high in CKD patients. YKL-40 could be used as a biomarker for inflammation and early detection of atherosclerosis in patients with CKD, but further studies are needed. YKL-40 is an independent predictor of increased CIMT and early atherosclerosis. YKL-40 is highly sensitive to increased CIMT.
DINÂMICAS DA AÇÃO COLETIVA NO BRASIL CONTEMPORÂNEO: encontros e desencontros entre o sindicalismo e a juventude trabalhadora
Authors: Braga Ruy , Aurélio Santana Marco 
Published: August 2022

Tendo em vista o lugar tradicional dos sindicatos como canal de organização e condução de conflitividade na sociedade brasileira, o artigo se propõe articular a reconfiguração das classes sociais no Brasil contemporâneo, as manifestações atuais da inquietação social e a situação dos sindicatos frente a essa nova configuração. A especial ênfase ao papel dos sindicatos nesta nova conjuntura global parte da premissa de que as diferentes respostas dos sindicatos nacionais ao advento do protagonismo político da juventude trabalhadora em condições precárias de vida e de trabalho representam uma oportunidade privilegiada de observação das atuais reconfigurações classistas em contextos de crise. Palavras-chave: Trabalho. Trabalhadores. Juventude. Sindicatos. Ação Coletiva. DYNAMICS OF COLLECTIVE ACTIONS IN CONTEMPORARY BRAZIL: agreements and disagreements between unionism and the youth worker force Ruy Braga Marco Aurélio Santana Taking into account the traditional Unions’ role in the conflict organization and mobilization in the Brazilian society, the article associates the social classes reconfiguration, contemporary social uneasiness and their impacts upon Brazilian Unionism. The main emphasis on Unions’ role is related to the hypothesis that the different responses from Unions to this new scenario is a privileged opportunity to observe the current social classes reconfiguration during a crisis period and the resulting dynamics of collective action. Keywords: Work. Workers. Youth. Unions. Collective Action DYNAMIQUES DE L’ACTION COLLECTIVE AU SEIN DU BRÉSIL CONTEMPORAIN: Convergences et divergences entre le syndicalisme et les jeunes travailleurs Ruy Braga Marco Aurélio Santana Compte tenu de la place traditionnelle occupée par les syndicats en tant que moyen d’organisation et de résolution des conflits dans la société brésilienne, cet article se propose d’articuler la reconfiguration des classes sociales au sein du Brésil contemporain, ainsi que les manifestations actuelles de l’inquiétude sociale et la situation des syndicats face à cette nouvelle configuration. L’accent mis tout particulièrement sur le rôle des syndicats dans cette nouvelle conjoncture mondiale part du principe que les différentes réponses des syndicats nationaux face à l’avènement du rôle politique de la jeunesse travaillant dans des conditions précaires de vie et de travail sont une excellente occasion pour observer les reconfigurations actuelles des paramètres de classe dans le contexte d’une crise. Mots-clés: Travail. Travailleurs. Jeunesse. Syndicats. L’action collective. Publicação Online do Caderno CRH no Scielo: http://www.scielo.br/ccrh Publicação Online do Caderno CRH: http://www.cadernocrh.ufba.br
A CAUSA E AS POLÍTICAS DE DIREITOS HUMANOS NO BRASIL
Authors: Engelmann Fabiano , Mori Madeira Lígia 
Published: August 2022

Pretende-se analisar a emergência e consolidação da causa dos direitos humanos no Brasil nas últimas dé- cadas. O argumento principal é que o movimento dos direitos humanos emerge, como em outros contextos da América latina, a partir da contestação do regime militar-autoritário e consolida-se a partir de marcos institucionais após a redemocratização do país. A análise do perfil das causas e dos trajetos dos principais líderes do movimento no Brasil permite afirmar que os direitos humanos transformam-se, ao longo da dé- cada de 90, em uma “causa de Estado”. Um dos indicadores mais forte dessa transformação é a articulação entre os movimentos militantes e a burocracia governamental e a expansão de programas de direitos humanos principalmente nas regiões sul, sudeste e norte. Palavras-chave: Brasil. Direitos Humanos. Ativismo. Políticas Públicas. HUMAN RIGHTS CAUSES AND POLICIES IN BRAZIL Fabiano Engelmann Lígia Mori Madeira This study analyzes the emergence and consolidation of the human rights cause in Brazil over the last decades. The main argument is that the human rights movement emerged, as in other Latin American contexts, from the fight against totalitarian regimes, and was consolidated with institutional achievements after the re-democratization of the country. Analyzing the profile of the causes and trajectories of the main leaders of the movement in Brazil enables us to state that the human rights have become, over the 1990s, a “cause of the State”. One of the strongest indicators of this transformation is the articulation between militant movements and the government bureaucracy, and the expansion of human rights programs across Brazil, especially in the South, Southeast and North. Keywords: Brasil. Human Rights. Activism. Public Policies LA CAUSE ET LES POLITIQUES DES DROITS DE L’HOMME AU BRÉSIL Fabiano Engelmann Lígia Mori Madeira L’article se veut d’analyser l’apparition et la consolidation de la cause des droits de l’homme au Brésil au cours des dernières décennies. Le principal argument est que le mouvement des droits de l’homme surgit, comme dans d’autres contextes en Amérique latine, de la contestation du régime militaire autoritaire et qu’il s’est consolidé dans le cadre institutionnel après la re-démocratisation du pays. L’analyse du profil des causes et de la trajectoire des principaux leaders du mouvement au Brésil nous permet d’affirmer que les droits de l’homme se sont transformés au cours des années 90 en une “cause d’État”. L’un des indicateurs les plus forts de cette transformation est le rapport entre les mouvements militants et la bureaucratie gouvernementale ainsi que l’expansion de programmes de défense des droits de l’homme, surtout dans les régions sud, sud-est et nord du pays. Mots-clés: Brésil. Droits de l’Homme. Activisme. Politiques Publiques. Publicação Online do Caderno CRH no Scielo: http://www.scielo.br/ccrh Publicação Online do Caderno CRH: http://www.cadernocrh.ufba.br
Neuron–Glial Interactions in Health and Brain Cancer
Authors: Pan Yuan , Monje Michelle 
Published: August 2022

AbstractBrain tumors are devastating diseases of the central nervous system. Brain tumor pathogenesis depends on both tumor‐intrinsic oncogenic programs and extrinsic microenvironmental factors, including neurons and glial cells. Glial cells (oligodendrocytes, astrocytes, and microglia) make up half of the cells in the brain, and interact with neurons to modulate neurodevelopment and plasticity. Many brain tumor cells exhibit transcriptomic profiles similar to macroglial cells (oligodendrocytes and astrocytes) and their progenitors, making them likely to subvert existing neuron–glial interactions to support tumor pathogenesis. For example, oligodendrocyte precursor cells, a putative glioma cell of origin, can form bona fide synapses with neurons. Such synapses are recently identified in gliomas and drive glioma pathophysiology, underscoring how brain tumor cells can take advantage of neuron–glial interactions to support cancer progression. In this review, it is briefly summarized how neurons and their activity normally interact with glial cells and glial progenitors, and it is discussed how brain tumor cells utilize neuron–glial interactions to support tumor initiation and progression. Unresolved questions on these topics and potential avenues to therapeutically target neuron–glia–cancer interactions in the brain are also pointed out.
Quantitative System Modeling Bridges the Gap between Macro‐ and Microscopic Stomatal Model
Authors: Rui Mengmeng , Jing Yi , Jiang Hangjin , Wang Yizhou 
Published: August 2022

AbstractAn understanding of stomatal function is vital for the carbon and water cycle in nature. In the past decades, various stomatal models with different functions have been established to investigate and predict stomatal behavior and its association with plants’ responses to the changing climate, but with limited biological information provided. On the other hand, many stomatal models at the molecular level focus on simulating and predicting molecular practices and ignore the dynamic quantitative information. As a result, stomatal models are often divided between the microscopic and macroscopic scales. Quantitative systems analysis offers an effective in silico approach to explore the link between microscopic gene function and macroscopic physiological traits. As a first step, a systems model, OnGuard, is developed for the investigation of guard cell ion homeostasis and its relevance to the dynamic stomatal movements. The system model has already yielded a series of important predictions to guide molecular physiological studies in stomata. It also exhibits great potential in breeding practice, which represents a key step toward “Breeding by design” of improving plant carbon–water use efficiency. Here, the development of stomatal models is reviewed, and the future perspectives on stomatal modeling for agricultural and ecological applications are discussed.