bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primum non Nocere: How to ensure continuity of care and prevent cancer patients from being overlooked during the COVID‐ 19 pandemic
Authors: Agostinelli Veronica , De Filippis Chiara , Torniai Mariangela , Rocchi Marco Bruno Luigi , Pagliacci Alessandra , Ricci Giulia , Corsi Rosina , Luzi Paolo , Caporossi Michele , Berardi Rossana 
Published: June 2022

AbstractBackgroundCoronavirus disease 2019 (COVID‐19) has spread to all countries since December 2019, triggering a pandemic within weeks of the initial outbreak. Doctors were presented with the challenge of having to reimagine the traditional hospital organisation in order to effectively manage patients.Patients and MethodsDuring the months of the COVID‐19 pandemic our Institution was assisted by a call‐center (CC) that triaged cancer patients planned for follow‐up in our outpatient clinics: C1 (for female cancers), C2 (for gastrointestinal, urogenital, and thoracic tumours), and D1 (for melanoma and for patients with tumours in over 5 years follow up). Data refers to the period between 15 April and 3 July 2020.ResultsA total of 1054 patients have been included in our study and 1005 (95%) of the contacts were successful. The analysis showed a majority of female patients (74%) and patients affected by breast cancer (56%). Among the options provided 646 patients (92.4%) opted for online consultancy.ConclusionThis study has shown that cancer patients valued technology‐mediated follow‐up visits mainly during the beginning of the pandemic because patients themselves were afraid to come to the hospital. Although telemedicine has intrinsic limitations, it is important for providing assistance and preventing cancer patients from feeling isolated during an emergency.
Anions Distorting Triggering Ferroelectricity in a Molecular Crystal†
Authors: Ye Si‐Yu , Liu Jing‐Yuan , Tong Liang , Wang Yan‐Ning , Wan Min , Mensah Abraham , Jiang Xiao‐Fan , Li Jun‐Yi , Chen Li‐Zhuang 
Published: June 2022

Comprehensive SummaryRecently, molecular ferroelectrics have attracted more and more attention due to their structural diversity, low cost of manufacture, and environmental‐friendly processing. However, most of the design strategies for molecular ferroelectrics have focused on the selection and modification of cations, and the use of anions has been rarely reported. Here, introducing distorted [CuBr4]2– tetrahedra, we obtained a high curie temperature (Tc) ferroelectric, [cyclopentylammonium]2CuBr4, with a Tc as high as 393 K, and exceeding commercial and most of reported molecular ferroelectric BaTiO3 (393 K). Variable‐temperature hysteresis loop shows the nonlinear P‐E loop of the crystal under a wide temperature range. Variable‐temperature single‐crystal X‐ray diffraction revealed that the Aizu expression can be written as mmmFmm2. In short, this work will inspire more creative strategies by exploiting the tunability of the anion module.
The liver X receptors agonist GW3965 attenuates depressive‐like behaviors and suppresses microglial activation and neuroinflammation in hippocampal subregions in a mouse depression model
Authors: Li Jing , Zhu Peilin , Li Yue , Xiao Kai , Tang Jing , Liang Xin , Luo Yanmin , Wang Jin , Deng Yuhui , Jiang Lin , Xiao Qian , Guo Yijing , Tang Yong , Huang Chunxia 
Published: June 2022

AbstractLiver X receptors (LXRs) have recently been reported to be novel and potential targets for the reversal of depressive‐like behaviors, but the mechanism remains unclear. Hippocampal neuroinflammation and impairment of the normal structure and function of microglia are closely associated with depression. To investigate the effects of LXRs agonist (GW3965) on neuroinflammation and microglia in the hippocampal formation of mice with chronic unpredictable stress (CUS)‐induced depression, depressive‐like behaviors were evaluated by behavioral tests, hippocampal LXRs gene expression were evaluated by qRT‐PCR, the protein expression levels of interleukin‐1β, tumor necrosis factor‐α, inducible nitric oxide synthase, nuclear factor kappa B, and cluster of differentiation 206 were estimated by western blotting, modern stereological methods were used to precisely quantify the total number of microglia in each hippocampal subregion, and immunofluorescence was used to detect the density of activated microglia and the morphology of microglia. We found that GW3965 alleviated the depressive‐like behavior induced by CUS, reversed the decrease in hippocampal LXRα and LXRβ induced by CUS, increased the protein expression of pro‐inflammatory factors, and decreased the protein expression of antiinflammatory factors induced by CUS. Moreover, CUS intervention significantly increased the number of microglia in the CA1 region, CA2/3 region, and dentate gyrus and the density of activated microglia in the CA2/3 region and dentate gyrus and significantly decreased the endpoints of microglial branches and process length of microglia in the dentate gyrus, while 4 weeks of injections with GW3965 reversed these changes. These findings suggest that regulating the number, activated state, and morphology of microglia in hippocampal subregions might be an important basis for the antidepressant effects of LXRs.
Photophysical and Photoelectrochemical Properties of CsPbBr3 Films Grown by Electrochemically Assisted Deposition
Authors: Gau Daniel L. , Ramírez Daniel , Iikawa Fernando , Riveros Gonzalo , Díaz Patricia , Verdugo Javier , Núñez Gerard , Lizama Susy , Lazo Pamela , Dalchiele Enrique A. , Contreras Lidia , Idigoras Jesús , Anta Juan , Marotti Ricardo E. 
Published: June 2022

AbstractPerovskite have had a great impact on the solid‐state physics world in the last decade not only achieving great success in photovoltaics but, more recently, also in the implementation of other optoelectronic devices. One of the main obstacles for the adoption of Pb‐based perovskite technologies are the high amounts of Pb needed in the conventional preparation methods. Here we present for the first time a detailed analysis of the photophysical and photoelectrochemical properties of CsPbBr3 films directly grown on fluorine‐doped tin oxide (FTO) coated glass through a novel technique based in the electrodeposition of PbO2 as CsPbBr3 precursor. This technique allows to save up to 90 % of the Pb used compared to traditional methods and can be scalable compared with the commonly used spin‐coating process. The low temperature analysis of their photoluminescence spectra, performed in both steady state and time dependence, revealed a strong interaction between electrons and longitudinal optical (LO) phonons dominant at high temperatures. On the other hand, the electrochemical and photoelectrochemical analysis proves that CsPbBr3 prepared using this new method has state‐of‐the‐art features, showing a p‐type behavior under depletion regime. This is also confirmed by photoelectrochemical measurements using p‐benzoquinone as target molecule. These results prove that the proposed method can be used to produce excellent CsPbBr3 films, saving much of the lead waste.
The control and evaluation method of the cascaded buck–boost converter for equalization on battery strings
Authors: Chen Guanhua , Wang Xueqi , Huang Linlu , Li Zexiang 
Published: June 2022

AbstractWith the further implementation of the carbon peak carbon neutral strategy, new energy vehicles will play an important cornerstone in the realization of this policy. However, the power source lithium battery pack has reduced the charge and discharge capacity due to the variation in the energy of the single cells, which largely limits the wide application of new energy vehicles. A cascaded buck–boost converter is proposed to balance the inconsistent energy in the battery pack. This equalization circuit is equipped with two fundamental working modes on which a matrix equalization strategy is developed and optimized accordingly. Then, the systematic evaluation method on average efficiency and time is applied to investigate the performance of the converter. Subsequently, the proposed converter and its control method have shown better performance than the existing equalization circuit via simulation and experimental verification. The design has high scalability and is expected to be applied to large‐scale energy storage systems to serve the construction of the global energy Internet.
Increased lead and glucocorticoid concentrations reduce reproductive success in house sparrows along an urban gradient
Authors: White Justin H. , Heppner Jennifer J. , Ouyang Jenny Q. 
Published: June 2022

AbstractUrbanization is increasing at a rapid pace globally. Understanding the links among environmental characteristics, phenotypes, and fitness enables researchers to predict the impact of changing landscapes on individuals and populations. Although avian reproductive output is typically lower in urban compared with natural areas, the underlying reasons for this discrepancy may lie at the intersection of abiotic and biotic environmental and individual differences. Recent advances in urban ecology highlight the effect of heavy metal contamination on stress physiology. As high levels of glucocorticoid hormones decrease parental investment, these hormones might be the link to decreased reproductive success in areas of high environmental pollution. In this study, we aimed to identify which abiotic stressors are linked to avian reproductive output in urban areas and whether this link is mediated by individual hormone levels. We used fine‐scaled estimates (2 m2 spatial resolution) of nighttime light, noise, and urban density to assess their impacts on the physiological condition of adult house sparrows (Passer domesticus). We measured circulating levels of lead and glucocorticoid concentrations in 40 breeding pairs of free‐living house sparrows and related these physiological traits to reproductive success. Using structural equation modeling, we found that increased urban density levels linked directly to increased plasma corticosterone and lead concentrations that subsequently led to decreased fledgling mass. Sparrows with increased lead concentrations in plasma also had higher corticosterone levels. Although urban areas may be attractive due to decreased natural predators and available nesting sites, they may act as ecological traps that increase physiological damage and decrease fitness. To illustrate, avian development is strongly explained by parental corticosterone levels, which vary significantly in response to urban density and lead pollution. With fine‐scale ecological mapping for a species with small home ranges, we demonstrated the presence and impacts of urban stressors in a small city with high human densities.
Testing the effectiveness of environmental DNA (eDNA) to quantify larval amphibian abundance
Authors: Breton Brie‐Anne A. , Beaty Lynne , Bennett Amanda M. , Kyle Christopher J. , Lesbarrères David , Vilaça Sibelle Torres , Wikston Madison J. H. , Wilson Chris C. , Murray Dennis L. 
Published: June 2022

AbstractEnvironmental DNA (eDNA) monitoring is rapidly becoming an established approach for detecting the presence of aquatic organisms and may also be useful for indexing or estimating species abundance. However, the link between eDNA concentration and abundance of individuals (i.e., density or biomass) remains tenuous and may vary widely across species and environmental conditions. We investigated the relationship between eDNA concentration and abundance in two common and closely related amphibians in eastern North America, the wood frog (Rana sylvatica), and northern leopard frog (R. pipiens). We manipulated tadpole density in 80‐L mesocosms and documented the relationship between tadpole density and biomass and eDNA concentration through time. The two species differed in the amount of detectible genetic material produced, despite having comparable biomass. Concentration of eDNA increased with tadpole numbers and was primarily correlated with tadpole density in wood frogs and biomass in leopard frogs. eDNA degradation rates were rapid and comparable between species, with tadpoles becoming indetectable within 5 days post‐removal from the mesocosm, irrespective of tadpole density. Overall, our findings support that eDNA concentration has potential for tracking amphibian abundance in wetlands, but that indices of abundance are likely to be coarse and species‐specific calibration will be required. Future research should address how biotic and abiotic factors influence eDNA production, degradation, and recovery across species and through time before relying on eDNA for monitoring amphibian abundance in nature.
Peri‐operative Takotsubo syndrome after non‐cardiac surgery: a retrospective nested case–control study
Authors: Shang Zhi , Zhao Menglin , Cai Jiageng , Wu Cencen , Xu Yuan , Zeng Lin , Cai Hong , Xu Mao , Fan Yuanyuan , Li Yanguang , Gao Wei , Xu Weixian , Zu Lingyun 
Published: June 2022

AbstractAimsTakotsubo syndrome (TTS) is an acute reversible cardiac dysfunction that may occur during the peri‐operative period and among patients with serious illness. We aimed to evaluate the clinical characteristics, peri‐operative management, and prognosis of peri‐operative TTS (pTTS) and explore the factors associated with pTTS.MethodsWe conducted a retrospective nested case–control study using the database of patients who underwent in‐hospital non‐cardiac surgeries between January 2017 and December 2020 in Peking University Third hospital. Cases were adult patients diagnosed TTS at discharge who were matched with four controls based on operative types. Multivariable conditional logistic regression was used to identified the factors associated with pTTS. The area under the curve (AUC) was used to evaluate the diagnostic efficacy.ResultsAmong the 128 536 patients underwent non‐cardiac surgery, 20 patients with pTTS and 80 patients without were enrolled in this study. The incidence of pTTS was about 0.016% in our centre. The median age of patients with pTTS was 52.5 (38.25, 76.25) years, although 90% of them were female. Fifty per cent (9 cases) of female patients were pre‐menopausal. Caesarean section has the highest proportion of pTTS (30% of the pTTS cases) with the incidence of caesarean section‐related pTTS of 0.06% in our centre. A high prevalence of non‐apical ballooning pattern of regional wall motion abnormality (seven cases, 35%) and a high mortality (two cases, 10%) were observed. Left ventricular ejection fraction (LVEF) of patients with pTTS was significantly decreased (41.7 ± 8.8%). In the acute phase, supportive treatments aiming to reduce life‐threatening complications were main treatment strategies. After receiving systematic treatment, significant improvements were observed in LVEF (63.1 ± 13.5%), with median recovery time of LVEF of 7.48 days. Leucocyte count [odds ratio (OR): 4.59; 95% confidence interval (CI): 1.10–19.15], haemoglobin (HGB) (OR: 10.52; 95% CI: 1.04–106.36), and the revised cardiac risk index (RCRI) score (OR: 6.30; 95% CI: 1.05–37.88) were the factors significantly associated with pTTS. The RCRI score performed poorly in the prediction of pTTS (AUC: 0.630; 95% CI: 0.525–0.735). After adding leucocyte count and HGB into the RCRI score, the AUC was significantly improved (AUC: 0.768; 95% CI: 0.671–0.865; P = 0.001).ConclusionsPatients with pTTS have some differences compared with common TTS, including higher proportion of pre‐menopausal female, higher prevalence during caesarean section, higher prevalence of non‐apical ballooning pattern of regional wall motion abnormality, and higher mortality. The RCRI score performed poorly in the evaluation of pTTS. Adding HGB and leucocyte count into the RCRI score could significantly improve its predictive performance.
Single‐Crystal‐to‐Single‐Crystal Transformation and Alcohols Enantioseparation of Homochiral Ir(III)‐Metallohelix‐Based Porous Molecular Crystal
Authors: Wu Jinguo , Li Xuezhao , Shi Zhuolin , He Cheng 
Published: June 2022

AbstractSingle‐crystal‐to‐single‐crystal (SCSC) transformations of porous crystals have been proved as an important platform for creating new materials. The current study describes porous molecular crystal with two different polymorphs based on the same chiral helicate modules can be controllably obtained when simply changing the crystallization solvents from diethyl ether to isopropyl ether. Interestingly, the β‐polymorph can also be effective obtained through SCSC transformations from α‐polymorph in solid state using isopropanol as a trigger. Compared with our reported α‐polymorph, the newly obtained β‐polymorph porous molecular crystal displays higher CO2 uptake and better selectivity for CO2 over N2 at 298 K. Meanwhile, as chiral solid adsorbents, both of β‐polymorph and α‐polymorph exhibit similar enantioselective separation abilities towards alcohols but different adsorption kinetics.
Muddying the muddle in the middle even more
Authors: Sarmiento Esteban E. , Pickford Martin 
Published: June 2022

AbstractIn an Evolutionary Anthropology article Roksandic et al. (2022) propose a new middle Pleistocene hominin species H. bodoensis to replace a “poorly defined” Homo heidelbergenis. Homo bodoensis extends from the African Middle Pleistocene through the Levant to South‐eastern Europe with all currently classified H. heidelbergensis fossils from western Europe subsumed into Homo neandertalensis. The authors claim their new species will be more clearly defined than H. heidelbergensis and will better describe hominin variation and evolution in the middle Pleistocene. Roksandic et al. are unable to account for some European fossils (i.e., Petralona and Arago) and provide no evidence as to how their new species meets their objectives. Fatally, they overlook the priority rule and fail to realize that H. bodoensis is both a junior synonym of Homo rhodesiensis and Homo saldanensis. Roksandic et al. conflate taxonomy with phylogeny, present hypotheses as facts, and harbor many systematic and evolutionary misconceptions.
When and how do business shutdowns work? Evidence from Italy's first COVID‐19 wave
Authors: Ciminelli Gabriele , Garcia‐Mandicó Sílvia 
Published: June 2022

AbstractGovernments around the world have adopted unprecedented policies to deal with COVID‐19. This paper zooms in on business shutdowns and investigates their effectiveness in reducing mortality. We leverage highly granular death registry data for almost 5000 Italian municipalities in a diff‐in‐diff approach that allows us to mitigate endogeneity concerns credibly. Our results, which are robust to controlling for a host of co‐factors, offer strong evidence that business shutdowns effectively curb mortality. We calculate that they may have reduced the death toll from the first wave of COVID‐19 in Italy by about 40%. Our findings also highlight that timeliness is key – by acting 1 week earlier, their effectiveness could have been increased by an additional 5%. Finally, shutdowns should be targeted. Closing service activities with a high degree of interpersonal contact saves the most lives. Shutting down production activities, while substantially reducing mobility, only has mild effects on mortality.
Development, usability and quality evaluation of the resilient mobile application for women with breast cancer
Authors: Rezaee Rita , Asadi Sima , Yazdani Azita , Rezvani Alireza , Kazeroon Arash Mani 
Published: June 2022

AbstractIntroductionMental health problems as a consequence of cancer lower the quality of life of cancer patients. Despite increasing studies of breast cancer‐focused mobile health applications (m‐Health apps), there is less research on breast cancer patients' quality of life or well‐being. The purpose of this study is to develop and evaluate the usability and quality of an educational m‐Health app aimed at improving the resilience of breast cancer in women.MethodsThis study was conducted in four phases. It included extracting the requirements of the app through the nominal group technique. Based on these results, an m‐Health app was developed and evaluated in terms of usability and quality by two scales, System Usability Scale and Mobile App Rating Scale questionnaires, respectively. Finally, the role of patients' age and educational backgrounds in the use of the app was assessed. The relationship between learnability and usability of the app was measured by the T‐Test.ResultsThe app was developed with three user interfaces. Its usability developed from the patient's point of view scored a remarkable score of 83.20 with a 95% confidence interval. This value was too indicative of high satisfaction with the usefulness and the possibility of recommending it to other cancer survivors. The results of the quality evaluation from an expert's point of view showed that this app had good functionality. Evaluation of the role of demographic information in the use of the app showed that it can be used for all age groups with different levels of education. The app did not differ significantly between learnability and usability.ConclusionThe development of m‐Health apps, based on usability principles that are suitable for all age groups with different levels of education, is welcomed by cancer patients.
Numerical investigation of activation energy of radiative magnetohydrodynamic Williamson nanofluid flow
Authors: Younus Mohammed , Venkata Lakshmi Akavaram 
Published: June 2022

AbstractThe activation energy (AE) of mixed convective, radiative magnetohydrodynamic Williamson nanofluid flow across an exponentially stretched sheet was investigated numerically. To convert the governing nonlinear partial differential equations into coupled ordinary differential equations, suitable similarity variables were introduced. The “Runge Kutta method” with the procedure of shooting was used to solve the resulting system of nonlinear ordinary differential equations with boundary conditions. The effects of various factors on profiles of nanoparticle volume fraction, temperature, and velocity were explored, and the results were presented graphically. The acquired results show that they are in great agreement with those found in the open literature. It is found that concentration profile is an increasing function of AE E whereas it decreases for chemical reaction rate constant and temperature difference . It is also evident from the table that the local Sherwood number rises as the chemical reaction rate constant and temperature differences arise, and falls as the AE is enhanced.
Wildfire and hydrological processes
Authors: Boyer Elizabeth W. , Wagenbrenner Joseph W. , Zhang Lu 
Published: June 2022

AbstractClimate change is a crucial factor in increasing wildfire risks, where warmer and drier conditions, increased drought periods and increased lightning strikes have made many areas more susceptible to burning. This special issue focuses on Wildfire and Hydrological Processes, exploring how wildfire has impacted watersheds and water resources. The manuscripts in this collection underscore how wildfire can change the nature of vegetation, characteristics of soils, hydrological flow paths, and residence times of water in the critical zone, and provide new insights toward predictability of wildfire impacts on watersheds. The studies reveal that wildfire can affect water quantity and quality over varying timescales, from during the active burning to years and decades afterward.