bluuebunny/crossref_metadata_2025_split huggingface dataset:
ДОСЛІДЖЕННЯ ФЛАВОНОЇДІВ ЧОРНОБРИВЦІВ ЗОЛОТИСТИХ (TAGETES LUCIDA CAV.)
Authors: Марчишин С. М. , Костишин Л. В. , Валько Т. В. , Кіщук В. М. , Паращук Е. А. 
Published: March 2022

Вступ. Перспективним джерелом одержання нових лікарських препаратів є види роду Чорнобривці (Tagetes), які культивують в Україні як технічну та декоративну рослину. Чорнобривці, завдяки їх лікувальним властивостям, використовують у традиційній медицині як імунозміцнювальний, протизапальний, гіпоглікемічний, жовчогінний та заспокійливий засіб. Маловивченим видом роду Tagetes є чорнобривці золотисті (Tagetes lucida Cav.). В Україні його ввели в культуру науковці відділу квітниково-декоративних рослин Національного ботанічного саду імені М. М. Гришка НАН України (м. Київ).
Мета дослідження – вивчити і порівняти вміст флавоноїдів у сировині (квітках, листках, коренях, насінні, стеблах) чорнобривців золотистих.
Методи дослідження. Флавоноїди виявляли в етанольно-водних витяжках за допомогою реакцій ідентифікації та методом тонкошарової хроматографії (ТШХ). Кількісний вміст суми флавoнoїдів визначали на спектрoфoтoметрі “UV-1800 Shimadzu” (Японія) за довжини хвилі 415 нм у перерахунку на рутин. Кількісний вміст індивідуальних флавоноїдних сполук виявляли і визначали методом високоефективної рідинної хроматографії (ВЕРХ) на хроматографі “Agilent 1200” (“Agilent Technologies”, США).
Результати й обговорення. Позитивні результати реакцій ідентифікації свідчили про наявність флавoнoїдів у сировині чорнобривців золотистих. Метoдoм ТШХ встанoвленo наявність у квітках, листках, коренях, насінні й стеблах кверцетину і кемпферолу. Рутин виявлено в усіх досліджуваних видах сировини, крім стебел. Метoдoм ВЕРХ у чорнобривців золотистих квітках та насінні виявлено по 6 індивідуальних флавоноїдів, у листках – 5, у коренях і стеблах – по 4. Найбільше у досліджуваних об’єктах виявлено кверцетину. В насінні, листках та квітках його вміст був найвищим і становив 6322,13 мкг/г, 4006,79 мкг/г та 3734,08 мкг/г відповідно. Усі види сировини чорнобривців золотистих містили також кемпферол, якого найбільше у квітках – 303,29 мкг/г. Спектрoфoтoметричним методом визначено, що найвищий вміст суми флавоноїдів є в насінні рослини, і він становить (7,89±0,18) %, найменше їх у стеблах – (1,86±0,08) %.
Висновки. Реакціями ідентифікації встановлено наявність флавоноїдів у чорнобривців золотистих квітках, листках, коренях, насінні й стеблах. Методом ТШХ виявлено кверцетин, кемпферол, рутин (крім стебел), ізокверцитрин (крім коренів), апігенін (лише у квітках). Методом ВЕРХ у чорнобривців золотистих квітках та насінні виявлено по 6 індивідуальних флавоноїдів, у листках – 5, у коренях і стеблах – по 4. Найбільше у досліджуваних об’єктах виявлено кверцетину. Спектрофотометричним методом визначено кількісний вміст суми флавоноїдів у сировині чорнобривців золотистих. Найвищий він у насінні – (7,89±0,18) %, дещо нижчий у листках – (6,58±0,12) %.
Canonical Workflows in Simulation-based Climate
Sciences
Authors: Anders Ivonne , Gehlen Karsten Peters-von , Thiemann Hannes 
Published: March 2022

Abstract
In this paper we present the derivation of Canonical Workflow Modules from current workflows in simulation-based climate science in support of the elaboration of a corresponding framework for simulation-based research. We first identified the different users and user groups in simulation-based climate science based on their reasons for using the resources provided at the German Climate Computing Center (DKRZ). What is special about this is that the DKRZ provides the climate science community with resources like high performance computing (HPC), data storage and specialised services, and hosts the World Data Center for Climate (WDCC). Therefore, users can perform their entire research workflows up to the publication of the data on the same infrastructure. Our analysis shows, that the resources are used by two primary user types: those who require the HPC-system to perform resource intensive simulations to subsequently analyse them and those who reuse, build-on and analyse existing data. We then further subdivided these top-level user categories based on their specific goals and analysed their typical, idealised workflows applied to achieve the respective project goals. We find that due to the subdivision and further granulation of the user groups, the workflows show apparent differences. Nevertheless, similar “Canonical Workflow Modules” can be clearly made out. These modules are “Data and Software (Re)use”, “Compute”, “Data and Software Storing”, “Data and Software Publication”, “Generating Knowledge” and in their entirety form the basis for a Canonical Workflow Framework for Research (CWFR). It is desirable that parts of the workflows in a CWFR act as FDOs, but we view this aspect critically. Also, we reflect on the question whether the derivation of Canonical Workflow modules from the analysis of current user behaviour still holds for future systems and work processes.
HPC-oriented Canonical Workflows for Machine Learning Applications in
Climate and Weather Prediction
Authors: Mozaffari Amirpasha , Langguth Michael , Gong Bing , Ahring Jessica , Campos Adrian Rojas , Nieters Pascal , Escobar Otoniel José Campos , Wittenbrink Martin , Baumann Peter , Schultz Martin G. 
Published: March 2022

Abstract
Machine learning (ML) applications in weather and climate are gaining momentum as big data and the immense increase in High-performance computing (HPC) power are paving the way. Ensuring FAIR data and reproducible ML practices are significant challenges for Earth system researchers. Even though the FAIR principle is well known to many scientists, research communities are slow to adopt them. Canonical Workflow Framework for Research (CWFR) provides a platform to ensure the FAIRness and reproducibility of these practices without overwhelming researchers. This conceptual paper envisions a holistic CWFR approach towards ML applications in weather and climate, focusing on HPC and big data. Specifically, we discuss Fair Digital Object (FDO) and Research Object (RO) in the DeepRain project to achieve granular reproducibility. DeepRain is a project that aims to improve precipitation forecast in Germany by using ML. Our concept envisages the raster datacube to provide data harmonization and fast and scalable data access. We suggest the Juypter notebook as a single reproducible experiment. In addition, we envision JuypterHub as a scalable and distributed central platform that connects all these elements and the HPC resources to the researchers via an easy-to-use graphical interface.
Canonical Workflows to Make Data FAIR
Authors: Wittenburg Peter , Hardisty Alex , Le Franc Yann , Mozaffari Amirpasha , Peer Limor , Skvortsov Nikolay A. , Zhao Zhiming , Spinuso Alessandro 
Published: March 2022

Abstract
The FAIR principles have been accepted globally as guidelines for improving data-driven science and data management practices, yet the incentives for researchers to change their practices are presently weak. In addition, data-driven science has been slow to embrace workflow technology despite clear evidence of recurring practices. To overcome these challenges, the Canonical Workflow Frameworks for Research (CWFR) initiative suggests a large-scale introduction of self-documenting workflow scripts to automate recurring processes or fragments thereof. This standardised approach, with FAIR Digital Objects as anchors, will be a significant milestone in the transition to FAIR data without adding additional load onto the researchers who stand to benefit most from it. This paper describes the CWFR approach and the activities of the CWFR initiative over the course of the last year or so, highlights several projects that hold promise for the CWFR approaches, including Galaxy, Jupyter Notebook, and RO Crate, and concludes with an assessment of the state of the field and the challenges ahead.
Using a Workflow Management Platform in Textual Data Management
Authors: Doan Triet Ho Anh , Bingert Sven , Yahyapour Ramin 
Published: March 2022

Abstract
The paper gives a brief introduction about the workflow management platform, Flowable, and how it is used for textual-data management. It is relatively new with its first release on 13 October, 2016. Despite the short time on the market, it seems to be quickly well-noticed with 4.6 thousand stars on GitHub at the moment. The focus of our project is to build a platform for text analysis on a large scale by including many different text resources. Currently, we have successfully connected to four different text resources and obtained more than one million works. Some resources are dynamic, which means that they might add more data or modify their current data. Therefore, it is necessary to keep data, both the metadata and the raw data, from our side up to date with the resources. In addition, to comply with FAIR principles, each work is assigned a persistent identifier (PID) and indexed for searching purposes. In the last step, we perform some standard analyses on the data to enhance our search engine and to generate a knowledge graph. End-users can utilize our platform to search on our data or get access to the knowledge graph. Furthermore, they can submit their code for their analyses to the system. The code will be executed on a High-Performance Cluster (HPC) and users can receive the results later on. In this case, Flowable can take advantage of PIDs for digital objects identification and management to facilitate the communication with the HPC system. As one may already notice, the whole process can be expressed as a workflow. A workflow, including error handling and notification, has been created and deployed. Workflow execution can be triggered manually or after predefined time intervals. According to our evaluation, the Flowable platform proves to be powerful and flexible. Further usage of the platform is already planned or implemented for many of our projects.
Service-Learning in the Ecuadorian Andes through Spanish, English and Kichwa Voicing
Authors: Yépez-Reyes Verónica , Ortiz Pacheco Karina A. 
Published: March 2022

Abstract
Community engagement projects create an avenue for university students and faculty to interact with local communities. These endeavors place together groups with different worldviews, cultures, and languages. Service-Learning (sl) has acquired novelty in academic circles; however, there has been limited research analyzing what happens with intercultural communication. This article attempts to fill this gap by asking how intercultural communication is shaped through sl. Research was conducted on a community engagement project in the Andean paramo of Chugchilán, Ecuador involving faculty, students, and members of the indigenous community. For the analysis, a blended design of transcendental phenomenology and sl methodology was used to analyze how participants perceive and make sense of their experience. From a linguistic perspective, we used both bilingualism and diglossia to analyze intercultural communication during the sl experience. The findings show that sl is a valid methodology that can increase intercultural communication while developing cultural competency between participants of the project. Finally, the study considers the revitalization of indigenous languages to be a fundamental step for a global intercultural world.
Agents of Ishq and Contemporary Discourses on Sex and Sex-Education in India
Authors: Biswas Anomitra , Guin Tonisha 
Published: March 2022

Abstract
This paper examines Agents of Ishq, an online site/project seeking to create a space for the public discourse of sex and sexuality in India, with particular attention to a single music video that is part of the project. The content produced by the project is informed by idioms of Bollywood films and film-music. The paper draws on the notion of popular culture to see how meanings are encoded within the video productions and explores the politics of representation of these audio-visual and textual resources. It also briefly examines the effect that being hosted on a digital platform, freely accessible at any time and from any location, (rather than as part of traditional and broadcast media) has on the content produced by Agents of Ishq. It examines the need for the proliferation of pedagogical resources of this kind and, at the same time, draws attention to the ways in which they need to be critically problematized in terms of the cultural hegemonies they may run the risk of reinforcing.
Fine-scale diversity in Rhodocybe mellea (Entolomataceae, Basidiomycota), with a description of a new variety and notes on sclerotia formation in Rhodocybe
Authors: XAVIER MIGUEL D. , SILVA-FILHO ALEXANDRE G. S. , WARTCHOW FELIPE , BASEIA IURI G. 
Published: March 2022

This study investigates morphological and genetic diversity in Rhodocybe mellea, after a new record of this species in the Brazilian Atlantic Forest. Phylogenetic analysis of molecular data (nrITS and nrLSU) and pairwise genetic distances, provide support for the recognition of cryptic lineages within R. mellea co-occurring in the Neotropics. We propose Rhodocybe mellea var. depressa as morphologically characterized by its depressed pileus, conspicuous sclerobasidia, small flexuous-cylindrical pseudocystidia, and a smooth cutis pileipellis. In addition, we also determine the position of nrITS sequences of some sclerotium-forming fungi collected in the same area, and confirm the genus Rhodocybe as a producer of this survival structure. Our findings provide unique information on Rhodocybe in South America, and highlight the relevance of approaches that address fine-scale diversity for fungal taxonomy.
Occultism and playing with the dead: When rituals go wrong
Authors: Vyshka Gentian , Elezi Fatime , Çomo Ariel , Xhemali Bledar 
Published: March 2022

There have been at least two deaths in Albania linked to ritualistic/satanic practices, which have provoked considerable public concern. Until the 1990s, Albania was strictly atheist. However, since then some religious sects have been establishing themselves. In fact, satanic killings and ritualistic deaths are rare in Albania. We describe two such cases that occurred in 2020 along with consideration of the psychological profiles of perpetrators and victims. The first case involved two deaths: a mother and daughter whose bodies were found near each other, with another daughter in attendance who was diagnosed as clearly psychotic, and legally did not face any charge thereafter. This daughter was witnessing the decomposition of her sister’s mummified corpse. She said she was waiting for the “Messiah” to resurrect her. Apparently, while performing ritualistic ceremonies, the daughter and her mother refused food until the mother died from starvation. It was at that point that police broke into the house and discovered the situation. The second case involved a young woman who was found dead, apparently following a trivial infection. Her body (abdomen and dorsum) had written symbols on it, suggesting Satanism and the occult. A detailed analysis of the death scenes and crime scenes provide valuable data for further proceedings, but psychological evaluation of the perpetrators may prove more difficult, and more so where the victims have died.
Delayed pathologic tibial fracture with chronic osteomyelitis after fibula free flap
Authors: Sagalow Emily S. , Kumar Ayan T. , Fried Tristan B. , Raikin Steven M. , Curry Joseph M. 
Published: March 2022

The reported donor site morbidity of the fibula free flap (FFF) is low; however, several uncommon complications have been reported with tibia fracture rarely being reported. We present a case of a pathological tibial fracture in the setting of chronic osteomyelitis after FFF. A 54-year-old female presented with a benign fibro-osseous lesion of the right mandible and was treated with mandibulectomy and reconstructed with a left FFF. Approximately 1 year following surgery, the patient presented to the emergency department. Imaging showed a pathological fracture of the distal third of the tibial shaft with persistent erythema and cellulitis of the lateral prior graft harvest site without signs of systemic infection. She was taken to the operating room for irrigation and debridement with culture and biopsy as well as external fixation of the tibial fracture. Intraoperative biopsy and culture demonstrated fracture site change with callus formation and negative culture. The patient was discharged on 6 weeks of IV vancomycin and ceftriaxone. In conclusion, tibial fracture following FFF is an uncommon complication, yet it can be exacerbated by chronic osteomyelitis. This report highlights the importance of close observation and comprehensive wound care of donor sites after free flap harvest for head and neck reconstruction.
Safety, tolerability, pharmacokinetics, and subjective effects of 50, 75, and 100 µg LSD in healthy participants within a novel intervention paradigm: A proof-of-concept study
Authors: Family Neiloufar , Hendricks Peter S , Williams Luke TJ , Luke David , Krediet Erwin , Maillet Emeline L , Raz Shlomi 
Published: March 2022

Background: Classic psychedelics hold promise as therapeutics for psychiatric disorders, but require scalable intervention protocols. This proof-of-concept study evaluated the safety, tolerability, pharmacokinetics, and subjective effects of 50, 75, and 100 µg lysergic acid diethylamide (LSD) in healthy adults within a novel intervention paradigm. Methods: Up to three participants were administered LSD on the same day in separate rooms, each with a single attendant, after 1 day of preparation. An open-label design and a double-blind placebo-controlled design were used. Results: Ninety-one percent of participants completed the study. Thirty-two adults (mean age = 28.8 years) received 50 (n = 3), 75 (n = 7), 100 (n = 3) LSD, 50 µg followed by 75 µg LSD (n = 9) 1 week apart, or placebo followed by a 75 µg LSD (n = 10) 1 week apart. There were no serious adverse events. Twenty-eight percent of participants experienced at least one expected mild adverse event, with one expected moderate adverse event. The maximum blood plasma levels occurred between 1.2 and 2 h post-administration, with an apparent half-life between 2.8 and 4.3 h. LSD largely induced greater subjective effects versus placebo. Conclusion: In the current novel intervention paradigm, 50, 75, and 100 µg LSD are tolerable with favourable safety profiles in healthy adults, only mild adverse events during the day of drug administration, and mystical-type subjective experiences. Future studies are needed to evaluate safety, tolerability, subjective effects, and cost-effectiveness in clinical populations.
Associations Between White Matter Microstructures and Cognitive Functioning in 8-Year-Old Children: A Track-Weighted Imaging Study
Authors: Raja Rajikha , Na Xiaoxu , Moore Alexandra , Otoo Raymond , Glasier Charles M. , Badger Thomas M. , Ou Xiawei 
Published: March 2022

Purpose Quantitative tractography using diffusion-weighted magnetic resonance imaging data is widely used in characterizing white matter microstructure throughout childhood, but more studies are still needed to investigate comprehensive brain-behavior relationships between tract-specific white matter measures and multiple cognitive functions in children. Methods In this study, we analyzed diffusion-weighted MRI data of 71 healthy 8-year-old children utilizing white matter tract-specific quantitative measures derived from diffusion-weighted MRI tractography based on a novel track-weighted imaging approach. Track density imaging, average path length map and 4 track-weighted diffusion tensor imaging measures including: mean diffusivity, fractional anisotropy, axial diffusivity, and radial diffusivity were computed for 63 white matter tracts. The track-weighted imaging measures were then correlated with a comprehensive set of neuropsychological test scores in different cognitive domains including intelligence, language, memory, academic skills, and executive functions to identify tract-specific brain-behavior relationships. Results Significant correlations ( P < .05, false discovery rate corrected; r = 0.27-0.57) were found in multiple white matter tracts, with a total of 40 correlations identified between various track-weighted imaging measures including average path length map, track-weighted imaging–fractional anisotropy, and neuropsychological test scores and subscales. Specifically, track-weighted imaging measures indicative of better white matter connectivity and/or microstructural development significantly correlated with higher IQ and better language abilities. Conclusion Our findings demonstrate the ability of track-weighted imaging measures in establishing associations between white matter and cognitive functioning in healthy children and can serve as a reference for normal brain/cognition relationships in young school-age children and further aid in identifying imaging biomarkers predictive of adverse neurodevelopmental outcomes.
Long-term outcomes of anti-VEGF treatment of macular oedema due to retinal vein occlusions
Authors: Corazza Paolo , D’Alterio Francesco Maria , Savastano Maria Cristina , Kabbani Jamil , Duguid Graham , Savastano Alfonso , Younis Saad 
Published: March 2022

Purpose retinal vein occlusion (RVO) is classified as either branch (BRVO) or central (CRVO) RVO. The gold standard treatment for macular oedema (MO) secondary to RVO is intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections. Our study aimed to compare ranibizumab and aflibercept outcomes over a maximum follow-up of five years. Methods this retrospective study assessed treatment-naïve RVO patients. Active disease was treated with three loading injections followed by a pro-re-nata (PRN) regimen of an anti-VEGF agent. Visual outcomes and injection frequency were analyzed, with patients stratified according to RVO subtype, anti-VEGF agent used, baseline vision, and age. Results 316 CRVO-affected eyes and 467 BRVO-affected eyes were analysed. Visual benefits between different treatments did not significantly differ, except in year 1 in ranibizumab-treated BRVO eyes. However, aflibercept-treated CRVO and BRVO eyes required significantly fewer injections during the follow up period. Furthermore, our results confirm that younger patients achieve better visual outcomes with fewer intravitreal injections. Overall, half of our patients did not require further injections after 1 year from diagnosis. Conclusion the results demonstrate that anti-VEGF treatment of RVO benefits vision for up to 5 years. Our findings are the first to suggest that compared to ranibizumab, fewer aflibercept injections may be required over five years follow up. Prospective randomised trials are needed to confirm this, alongside further attention to OCT scan features and the effect of patient demographics on treatment outcomes.