bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk of out-of-hospital cardiac arrest in patients with rheumatoid arthritis: a nationwide study
Authors: Hegazy Hatem , Folke Fredrik , Coronel Ruben , Torp-Pedersen Christian , Gislason Gunnar H , Eroglu Talip E 
Published: June 2022

AimInflammatory cytokines in patients with rheumatoid arthritis (RA) directly affect cardiac electrophysiology by inhibiting cardiac potassium currents, leading to delay of cardiac repolarisation and QT-prolongation. This may result in lethal arrhythmias. We studied whether RA increases the rate of out-of-hospital cardiac arrest (OHCA) in the general population.MethodsWe conducted a nested case–control in a cohort of individuals between 1 June 2001 and 31 December 2015. Cases were OHCA patients from presumed cardiac causes, and were matched with non-OHCA-controls based on age, sex and OHCA date. Cox-regression with time-dependent covariates was conducted to assess the association between RA and OHCA by calculating the HR and 95% CI. Stratified analyses were performed according to sex and presence of cardiovascular diseases. Also, the association between OHCA and use of non-steroidal anti-inflammatory drugs (NSAIDs) in patients with RA was studied.ResultsWe included 35 195 OHCA cases of whom 512 (1.45%) had RA, and 351 950 non-OHCA controls of whom 3867 (1.10%) had RA. We found that RA was associated with increased rate of OHCA after adjustment for cardiovascular comorbidities and use of QT-prolonging drugs (HR: 1.22, 95% CI: 1.11 to 1.34). Stratification by sex revealed that increased OHCA rate occurred in women (HR: 1.32, 95% CI: 1.16 to 1.50) but not in men (HR: 1.12, 95% CI: 0.97 to 1.28; P value interaction=0.046). OHCA rate of RA was not further increased in patients with cardiovascular disease. Finally, in patients with RA, use of NSAIDs was not associated with OHCA.ConclusionIn the general population, RA is associated with increased rate of OHCA in women but not in men.
Distance sensitivity of thermal light second-order interference beyond spatial coherence
Authors: Pepe Francesco V. , Scala Giovanni , Chilleri Gabriele , Triggiani Danilo , Kim Yoon-Ho , Tamma Vincenzo 
Published: June 2022

AbstractWe demonstrate the distance sensitivity of thermal light second-order interference beyond spatial coherence. This kind of interference, emerging from the measurement of the correlation between intensity fluctuations on two detectors, is sensitive to the distances separating a remote mask from the source and the detector, even when such information cannot be retrieved by first-order intensity measurements. We show how the sensitivity to such distances is intimately connected to the degree of correlation of the measured interference pattern in different experimental scenarios and independently of the spectral properties of light. Remarkably, in specific configurations, sensitivity to the distances of remote objects can be preserved even in the presence of turbulence. Unlike in previous schemes, such a distance sensitivity is reflected in the fundamental emergence of new critical parameters which benchmark the degree of second-order correlation, describing the counterintuitive emergence of spatial second-order interference not only in the absence of (first-order) coherence at both detectors but also when first-order interference is observed at one of the two detectors.
Multi-Label Annotation and Classification of Arabic Texts Based on Extracted Seed Keyphrases and Bi-Gram Alphabet Feed Forward Neural Networks Model
Authors: Elghannam Fatma 
Published: June 2022

In natural language processing, text classification is a fundamental problem. Multi-label classification of textual data is a challenging topic in text classification where an instance can be associated with more than one label. This paper presents a multi-label annotation and classification methodology for Arabic text data that is not currently classified as multi-label, aiming to analyze and compare the performance of various multi-label learning approaches. The current work includes two phases: The first involves automatic annotation of hotel reviews with more than one label based on the aspects found in the reviews. In this phase, review data instances were automatically annotated as multi-label based on the extracted seed keyphrases clusters. The second phase involves experiments to compare the performance of various multi-label classification learning methods. In this phase, we introduced different models including a feed-forward networks model that learns a vector representation based on the bi-gram alphabet rather than the commonly used bag-of-words model. The bi-gram alphabet vector representation model has the advantage of having reduced feature dimensions and not requiring natural language processing tools. The results indicated that employing the bi-gram alphabet vector representation feed forward neural network is a competitive solution for the multi-label text classification problem. It has achieved an accuracy of about 75.2%, and standard deviation (0.062).
Can Drug Repurposing Accelerate Precision Oncology?
Authors: Schipper Luuk J. , Zeverijn Laurien J. , Garnett Mathew J. , Voest Emile E. 
Published: June 2022

Abstract

Ongoing new insights in the field of cancer diagnostics, genomic profiling, and cancer behavior have raised the demand for novel, personalized cancer treatments. As the development of new cancer drugs is a challenging, costly, and time-consuming endeavor, drug repurposing is regarded as an attractive alternative to potentially accelerate this. In this review, we describe strategies for drug repurposing of anticancer agents, translation of preclinical findings in novel trial designs, and associated challenges. Furthermore, we provide suggestions to further utilize the potential of drug repurposing within precision oncology, with a focus on combinatorial approaches.

Significance:
Oncologic drug development is a timely and costly endeavor, with only few compounds progressing to meaningful therapy options. Although repurposing of existing agents for novel, oncologic indications provides an opportunity to accelerate this process, it is not without challenges.
Omega‐3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose‐Response Meta‐Analysis of Randomized Controlled Trials
Authors: Zhang Xin , Ritonja Jennifer A. , Zhou Na , Chen Bingshu E. , Li Xinzhi 
Published: June 2022

Background
Current evidence might support the use of omega‐3 fatty acids (preferably docosahexaenoic acid and eicosapentaenoic acid) for lowering blood pressure (BP), but the strength and shape of the dose‐response relationship remains unclear.

Methods and Results
This study included randomized controlled trials published before May 7, 2021, that involved participants aged ≥18 years, and examined an association between omega‐3 fatty acids (docosahexaenoic acid, eicosapentaenoic acid, or both) and BP. A random‐effects 1‐stage cubic spline regression model was used to predict the average dose‐response association between daily omega‐3 fatty acid intake and changes in BP. We also conducted stratified analyses to examine differences by prespecified subgroups. Seventy‐one trials were included, involving 4973 individuals with a combined docosahexaenoic acid+eicosapentaenoic acid dose of 2.8 g/d (interquartile range, 1.3 g/d to 3.6 g/d). A nonlinear association was found overall or in most subgroups, depicted as J‐shaped dose‐response curves. The optimal intake in both systolic BP and diastolic BP reductions (mm Hg) were obtained by moderate doses between 2 g/d (systolic BP, −2.61 [95% CI, −3.57 to −1.65]; diastolic BP, −1.64 [95% CI, −2.29 to −0.99]) and 3 g/d (systolic BP, −2.61 [95% CI, −3.52 to −1.69]; diastolic BP, −1.80 [95% CI, −2.38 to −1.23]). Subgroup studies revealed stronger and approximately linear dose‐response relations among hypertensive, hyperlipidemic, and older populations.

Conclusions
This dose‐response meta‐analysis demonstrates that the optimal combined intake of omega‐3 fatty acids for BP lowering is likely between 2 g/d and 3 g/d. Doses of omega‐3 fatty acid intake above the recommended 3 g/d may be associated with additional benefits in lowering BP among groups at high risk for cardiovascular diseases.
Immersive Spatial Interactivity in Sonic Arts: The Acoustic Localization Positioning System
Authors: Schlienger Dominik , Khashchanskiy Victor 
Published: June 2022

Abstract
The Acoustic Localization Positioning System is the outcome of several years of participatory development with musicians and artists having a stake in sonic arts, collaboratively aiming for nonobtrusive tracking and indoors positioning technology that facilitates spatial interaction and immersion. Based on previous work on application scenarios for spatial reproduction of moving sound sources and the conception of the kinaesthetic interface, a tracking system for spatially interactive sonic arts is presented here. It is an open-source implementation in the form of a stand-alone application and associated Max patches. The implementation uses off-the-shelf, ubiquitous technology. Based on the findings of tests and experiments conducted in extensive creative workshops, we show how the approach addresses several technical problems and overcomes some typical obstacles to immersion in spatially interactive applications in sonic arts.
Characterisation of Ficophagus virens (Bartholomaeus, Davies, Kanzaki, Ye & Giblin-Davis, 2009) Davies & Bartholomaeus, 2015 from Ficus virens (Moraceae) in India with a tabular key for the Indian species of Ficophagus
Authors: Waghmare Chandramani , Somvanshi Vishal S. , Khan Matiyar Rahaman 
Published: June 2022

Summary
A population of Ficophagus was recovered from white fig (Ficus virens) in New Delhi, India. We further described the population as Ficophagus virens based on morphological and morphometric characters, and molecular data. A detailed description of key morphological features, measurements of taxonomic characters, and photomicrography of the male and female specimens are given here. The study also included additional parameters such as lip diam. and height, conus stylet, shaft stylet, knobs diam. and height, vulva position from anterior end, length and width of spermatheca, anal/cloacal body diam., vulval width, and ovary/testis length for better characterisation of species. In addition to 28S rDNA (D2/D3), new sequence data from small subunit rDNA (18S) and mitochondrial cytochrome oxidase I COI marker gene were added. The D2/D3 sequence of F. virens was most similar to the sequence available for the Australian population of F. virens in GenBank. Maximum likelihood (ML) and Bayesian methods were used to analyse phylogenetic relationships of the Indian population of F. virens with those of the Australian populations and other Ficophagus species. This species is a new record from Delhi, India, and hence this report provides a new geographical location for the F. virens nematode after the first report from Australia.
The Possibility of the Nobler (imkān al-ashraf) in Ṣadrā’s Philosophy and Its Historical Origins
Authors: Erdt Agnieszka 
Published: June 2022

Abstract
The principle known as the possibility of the nobler (qāʿidat imkān al-ashraf) is arguably one of the most often employed principles in later Islamic philosophy. In its standard formulation it states that if something baser exists, a nobler thing must have existed prior to it. A similar argument from the degrees of perfections has had a long career in the history of Western philosophy as well, with its beginnings reaching Stoicism. In Christian theology and philosophy it serves most importantly as a proof for the existence of God in the so-called henological argument of Aquinas. In Islamic philosophy it directly derives from the ex uno non fit nisi unum principle. Since the formulation of its standard version by al-Suhrawardī, the validity of the principle has been conditioned on that it is only applicable to the intelligible beings, hence its main objective is to offer a proof for the existence of the intellects. The article analyzes the application of the principle in Ṣadrā’s philosophy and enquires about its historical roots.
Physics and Metaphysics in an Early Ottoman Madrasa: Dāwūd al-Qayṣarī on the Nature of Time
Authors: Todd Richard 
Published: June 2022

Abstract
Although overshadowed by his celebrated commentaries on Ibn ʿArabī and Ibn al-Fāriḍ, Dāwūd al-Qayṣarī’s (d. 750/1351) treatise on the philosophy of time – the Nihāyat al-bayān fī dirāyat al-zamān (The Utmost Elucidation Concerning Knowledge of Time) – is a notable milestone in the history of Islamic conceptions of temporality. Composed around the start of Qayṣarī’s tenure as head of the first Ottoman madrasa, the Nihāyat al-bayān rejects the Aristotelian definition of time as the number of motion in favor of Abū l-Barakāt al-Baghdādī’s concept of zamān as the measure of being. Challenging, likewise, portrayals of time as a flux or succession of fleeting instants, Qayṣarī propounds instead an absolutist vision of time as an integral, objectively existent whole. Qayṣarī’s reassessment of dominant medieval theories of temporality – including kalām atomism and the Neoplatonic distinction between time, perpetuity, and eternity – is thus shown to be a key early example of what was to become an abiding Ottoman interest in time and timekeeping.
The “Most Liberal in nato”?
Authors: Storkmann Klaus 
Published: June 2022

Abstract
Homosexuality was a topic that all armed forces were compelled to address at some point – and still are. A comparison between armed forces from around the world helps to put the actions of one state in the context of a bigger picture. This is not only the approach of historians today, but, as this research surprisingly shows, was the approach of the (West) German Federal Ministry of Defence (FMoD) in the late 1960s and after. Using archival sources from the German FMoD, this article examines how the (West) German MoD was interested in and viewed the regulations of other countries’ armed forces when dealing with homosexual service members, and whether and how these insights influenced the actions of the Defence Ministry.1
Disparities in Screening for Colorectal Cancer Based on Limited Language Proficiency
Authors: Cataneo Jose L. , Kim Tae David , Park John J. , Marecik Slawomir , Kochar Kunal 
Published: June 2022

Background This study analyzes the association between limited language proficiency and screening for colorectal cancer. Methods This is a retrospective cohort study from the 2015 sample of the National Health Interview Survey database utilizing univariate and multivariate regression analysis. The study population includes subjects between 50 and 75 years of age. The main outcome analyzed was rates of screening colonoscopies between limited English-language proficiency (LEP) subjects and those fluent in English. Secondary outcomes included analysis of baseline, socioeconomic, access to health care variables, and other modalities for colorectal cancer screening between the groups. Results Incidence of limited language proficiency was 4.8% (n = 1978, count = 4 453 599). They reported lower rates of screening colonoscopies (61% vs 34%, P < .001), less physician recommendation for a colonoscopy (87 vs 60%, P < .001), fewer polyps removed in the previous 3 years (24% vs 9.1%; P < .001), and fewer fecal occult blood samples overall (P < .001). Additionally, Hispanic non-LEP subjects have higher rates of colonoscopies compared to those with language barriers (50% vs 33%, P < .001). On multivariate analysis, LEP was associated with a lower likelihood to have a screening colonoscopy (OR .67 95% CI .49-.91). A second regression model with “Spanish language” and “other language” variables included, associated Spanish speakers with a lower likelihood for a screening colonoscopy (OR .71 95% CI .52-.97) when controlling for baseline, socioeconomic, and access to health care covariates. Discussion Patients with limited English-language proficiency are associated with lower rates of screening for colorectal cancer, in particular the Spanish speaking subgroup.
Incidence of and risk factors for alcohol dependence in bipolar disorder: A population-based cohort and nested case–control study
Authors: Hsu Haw-En , Chen Po-Yu , Chang Hu-Ming , Pan Chun-Hung , Su Sheng-Shiang , Tsai Shang-Ying , Chen Chiao-Chicy , Kuo Chian-Jue 
Published: June 2022

Objectives: Although alcohol dependence is highly prevalent in patients with bipolar disorder, the causal relationship is not yet well-established. This study estimated the incidence of alcohol dependence in a nationwide bipolar disorder cohort and examined risk factors for alcohol dependence. Methods: Patients aged 15–65 years with consistent bipolar disorder who had their first psychiatric admission between 1999 and 2012 ( n = 21,791) were enrolled from the National Health Insurance Research Database in Taiwan. We calculated the adjusted incidence rate ratio of alcohol dependence in the bipolar cohort relative to the general population after stratification by age and sex. In the nested case–control study, we included patients with incident alcohol dependence as cases and four age- and sex-matched controls for each case to analyze health care utilization, comorbidities and concomitant medications between them. Results: We identified 1261 patients with bipolar disorder with incident alcohol dependence. Relative to the general population, the adjusted incidence rate ratio of alcohol dependence was 9.20 in the bipolar cohort. All adjusted incidence rate ratios were high across all age subgroups. Cases had higher psychiatric and nonpsychiatric health care utilization than did controls. Multivariate analysis revealed that cases tended to have cardiovascular disease, diabetes mellitus, chronic hepatic disease, pneumonia and delirium before alcohol dependence diagnosis. Cases had higher psychiatric comorbidities, namely drug-induced mental disorders, anxiety disorder, personality disorder, adjustment disorder and sleep disorder. Conclusion: The bipolar cohort had a higher incidence of alcohol dependence. We identified specific groups with a high risk of alcohol dependence. Additional strategies for early detection, treatment and intervention for alcohol dependence should be developed.
Emergency Department and Intensive Care Unit Overcrowding and Ventilator Shortages in US Hospitals During the COVID-19 Pandemic, 2020-2021
Authors: Sandhu Paramjit , Shah Ami B. , Ahmad Farida B. , Kerr Justin , Demeke Hanna B. , Graeden Ellie , Marks Suzanne , Clark Hollie , Bombard Jennifer M. , Bolduc Michele , Hatfield-Timajchy Kendra , Tindall Erica , Neri Antonio , Smith Kelsey , Owens Chantelle , Martin Tonya , Strona Frank V. 
Published: June 2022

Objective: In 2020, the COVID-19 pandemic overburdened the US health care system because of extended and unprecedented patient surges and supply shortages in hospitals. We investigated the extent to which several US hospitals experienced emergency department (ED) and intensive care unit (ICU) overcrowding and ventilator shortages during the COVID-19 pandemic. Methods: We analyzed Health Pulse data to assess the extent to which US hospitals reported alerts when experiencing ED overcrowding, ICU overcrowding, and ventilator shortages from March 7, 2020, through April 30, 2021. Results: Of 625 participating hospitals in 29 states, 393 (63%) reported at least 1 hospital alert during the study period: 246 (63%) reported ED overcrowding, 239 (61%) reported ICU overcrowding, and 48 (12%) reported ventilator shortages. The number of alerts for overcrowding in EDs and ICUs increased as the number of COVID-19 cases surged. Conclusions: Timely assessment and communication about critical factors such as ED and ICU overcrowding and ventilator shortages during public health emergencies can guide public health response efforts in supporting federal, state, and local public health agencies.
Subclinical systolic dysfunction by speckle tracking echocardiography in patients with systemic lupus erythematosus
Authors: Azpiri-Lopez Jose R , Galarza-Delgado Dionicio A , Garza-Cisneros Andrea N , Guajardo-Jauregui Natalia , Balderas-Palacios Mario A , Garcia-Heredia Alexis , Cardenas-de la Garza Jesus A , Rodriguez-Romero Alejandra B , Reyna-de la Garza Roberto A , Azpiri-Diaz Hernan , Alonso-Cepeda Othon , Colunga-Pedraza Iris J 
Published: June 2022

Background We aimed to compare the prevalence of subclinical left ventricular systolic dysfunction in Hispanic systemic lupus erythematosus (SLE) patients versus healthy controls. Material and methods This cross-sectional study included 46 SLE patients who fulfilled the 2019 European League Against Rheumatism and American College of Rheumatology (EULAR/ACR) classification criteria for SLE and with age ≥ 18 years. For comparison, we included a control group with 46 non-SLE subjects matched by age (±5 years) and gender. A transthoracic echocardiogram was performed on every participant. The echocardiographic measurements evaluated were left ventricular ejection fraction (LVEF), relative wall thickness (RWT), and tricuspid annular plane systolic excursion (TAPSE). Left ventricular-Global Longitudinal Strain (GLS) was evaluated, and a value higher than −18% was classified as subclinical left ventricular systolic dysfunction. Comparisons between groups were made using the Chi-square test or Fisher’s exact test for qualitative variables, and Student’s t-test or the Mann–Whitney’s U test for quantitative variables. A p-value <.05 was considered significant. Results We found a significant difference in the presence of subclinical left ventricular systolic dysfunction between SLE-patients and controls (37.0% vs 8.7%, p = .001). We also found that SLE patients had a lower left ventricular GLS (−18.90% vs −20.51%, p = .011), TAPSE (21.63 mm vs 23.60 mm, p = .009), and LVEF (57.17% vs 62.47%, p = <.001) than controls. Systemic lupus erythematosus diagnosis was independently associated with the presence of subclinical left ventricular systolic dysfunction with an OR of 6.068 (CI 95% 1.675−21.987) ( p = .006). Subclinical systolic dysfunction was more common in men (29.4% vs 3.4%, p = .020), patients with obesity (17.6% vs 0%, p = .045), or hypertension (47.1% vs 6.9%, p = .001). Conclusion Systemic lupus erythematosus Hispanic patients had a higher prevalence of subclinical left ventricular systolic dysfunction, and worse left ventricular GLS, LVEF, and TAPSE values than matched healthy controls. Additionally, we found that male gender, obesity, and hypertension are associated with the presence of subclinical left ventricular systolic dysfunction in SLE patients. The inclusion of speckle tracking echocardiography as part of the cardiovascular evaluation of SLE patients may help identify high cardiovascular risk patients.