bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct and indirect health‐related costs of systemic sclerosis in New Zealand
Authors: Padala Sree Deepika , Lao Chunhuan , Solanki Kamal , White Douglas 
Published: September 2022

AbstractAimTo study the economic impact of systemic sclerosis (SSc) in the patients attending Rheumatology clinics in Waikato Hospital, Hamilton, New Zealand (NZ). There is currently no bottom‐up data on this in NZ.MethodsThis is a retrospective cross‐sectional questionnaire‐based study, including demographics, costs related to SSc, quality of life measures including the short‐form survey (SF‐36) the scleroderma health assessment questionnaire‐visual analog scale (SHAQ‐VAS), the NZ index of Deprivation (NZiDep), and work limitations questionnaire (WLQ). Direct health costs include patient‐reported costs and costs incurred by the public health system. Indirect costs include calculated loss of work productivity. Comparisons were made between age, gender, disease duration, and disease subtype (diffuse, limited, and overlap syndromes).ResultsParticipants fulfilled the 2013 ACR/EULAR criteria for SSc. The study was completed by 86 (65.5%) patients, 77 (90%) were females, 19 (22%) had diffuse cutaneous systemic sclerosis (dcSSc), 72 (83%) were NZ European (NZE), seven(8%) were Māori or NZE/Māori. Seventy‐six (41.8%) were employed. The average total costs for 6 months were NZ$ 444.50 with the highest costs in the dcSSc sub‐group at NZ$ 598.00. The costs incurred by the Hospital for the 2018/2019 fiscal year was NZ$ 3091 per patient. The SF‐36 score was lower compared with the general population, mean SHAQ was 0.82. Mean summative WLQ scores were: Time management 21.7, Physical demands 62.5, Interpersonal 23.6, Output demands 23.8. The calculated percentage productivity loss was 46.5%.ConclusionsThis study has shown high health‐related costs of SSc in NZ, with reduction in employment, work productivity, and quality of life. The contributors to the costs included physical disability and loss of productivity.
Gouty sacroiliitis: A case report of an often‐overlooked cause of inflammatory back pain
Authors: Guo Qi‐Hong , Lu Jun‐Guang , Zheng Bao‐Lin , Li Ting , Chen Shih‐Hsuan 
Published: September 2022

AbstractGout is a chronic disease caused by monosodium urate crystal deposition, typically affecting the big toe, midfoot, and ankle. As it rarely involves the sacroiliac joints, it could be easily misdiagnosed as spondylarthritis. Here, we report the case of a patient with a long history of gout with recurrent low back pain. Computed tomography of the sacroiliac joint suggested sacroiliac arthritis, puncture biopsy indicated gout granuloma, and polarized light microscopy confirmed monosodium urate crystal deposits.
Archaeology in 2021: Repatriation, reclamation, and reckoning with historical trauma
Authors: Montgomery Lindsay M. , Supernant Kisha 
Published: September 2022

AbstractArchaeology in 2021 was characterized by a continued call to use the tools of the discipline to document the violence of settler colonialism in the past and present, pushing anthropology to reckon with its own role in perpetuating historical trauma. The tension between disciplinary reflection and reform was most clearly articulated in the use of archaeological geophysics to detect the unmarked graves of incarcerated Indigenous children who died at residential and boarding schools in Canada and the United States. The highly publicized investigation of these schools has brought renewed attention to issues of repatriation and historical reclamation for many communities impacted by settler colonialism. These discussions have reverberated throughout the discipline, prompting revisions to the Society for American Archaeology's “Statement Concerning the Treatment of Human Remains,” reopening conversations around an African American Graves Protection and Repatriation Act, and informing debates around the ethics of DNA research. These conversations are part of a larger movement toward decolonizing the field by using archaeological methods to explore marginalized histories and support communities most impacted by the violences of settler colonialism.
Well‐being and experiences of adults in German federal states under pandemic conditions
Authors: Wolgast Anett , Bruns Katherine , Werner Laura , Reinhaus David 
Published: September 2022

AbstractResearch on people's experiences during the Covid‐19‐pandemic provides growing evidence on subjective well‐being and distress under pandemic conditions, however mainly at a country, not state level. The relationship between positive and negative experiences is described in Diener's conceptualization of subjective well‐being. We assumed that people who experience well‐being and positive affect through connectedness with nature, and social support during the pandemic feel relatively less alone, distressed, depressed, self‐focused, and thoughtless. We further assumed changes in these constructs during the pandemic. The aim of this research was to examine the concurrent relationships between these positive and negative experiences of German adults simultaneously as well as their changes over 3 weeks in 2020. Owing to German federalism, we expected these changes to differ between German states. A sample of 1,038 adults responded to an online questionnaire twice (April and May 2020). A structural equation model including 16 factors and 12 covariates yielded the expected negative relationships and different mild change effects between the German states. For example, adults' connectedness with nature increased while loneliness and distress decreased in Saxony, whereas thoughtlessness increased in Bavaria. The results imply a new finding that different changes in adults' positive and negative experiences during the pandemic exist.
Origin of Lower Cretaceous quartzose arenites in northern India and the Indus Basins of Pakistan—The result of provenance composition, weathering or diagenesis?
Authors: Beaumont Hazel , Burley Stuart D. , Breitfeld Tim , Gould Thomas , Clarke Stuart M. 
Published: September 2022

AbstractLower Cretaceous (Aptian‐Albian) sandstones of the Ghaggar‐Hakra Formation in the Barmer Basin of northwest Rajasthan, India, have a complex depositional history which is confusing given they are quartzose arenites. The heavy mineral grains are very well‐rounded, and the assemblage is dominated by zircon and rutile grains suggesting that the sediments have been recycled multiple times, whilst the presence of staurolite indicates a metapelite provenance component. Petrographical analysis suggests that extreme diagenesis cannot account for the quartzose arenite composition, despite Early Cretaceous soil formation and at least two periods of subsequent telogenetic modification. An alternative explanation to extreme chemical weathering in the provenance area is that the Ghaggar‐Hakra sandstones are multi‐cycle sediments derived, at least in part, from the quartzose arenites of the Cambrian Jodhpur Group. This analysis suggests that variations in detrital mineralogy across the Western India Rift System and Indus Basins are the result of transcontinental fluvial transport systems sourcing sediment from specific basement highs (Nagar Parker High, Devikot High, Deodar Ridge and Aravalli Mountain Range) mixed with varying proportions of sediment derived from sandstones of the Jodhpur Group. Consequently, we suggest that Cretaceous fluvial systems were controlled by the local palaeogeographies within the failed rifts of the Barmer and Cambay Basins and that both basins formed barriers to sediment transport from the Aravalli Mountain Range across the northwest Indian plate and into surrounding basins.
What do fiscal stimulus packages mean for household debt?
Authors: Olivero María Pía , Dvalishvili Mikheil 
Published: September 2022

AbstractWe study the links between fiscal stimulus packages during times of crisis and households' liabilities. We do so by using household‐level data on income and liabilities from the Consumer Expenditure Survey, and estimating an empirical model along those in the literature on the consumption effects of these packages. We find that receiving a check from the government tends to translate into a reduction in outstanding liabilities for American households. This effect is robust to controlling for income levels and household size. The effects are driven by households whose income is below the median and by those who remain employed during the crisis.
Usability of cellulose‐based binder in water‐based flexographic ink
Authors: Sonmez Sinan , Salam Abdus , Fleming Paul D. , Pekarovicova Alexandra , Wu Qingliu 
Published: September 2022

AbstractPackaging must have a good commercial appearance and is generally obtained by ink transferred to its substrate. It is important that the ink used in packaging printing is produced from environmentally friendly and sustainable raw materials as well as being suitable for the printing system. The increasing demand in the field of printed packaging and the scarcity of resources to meet this demand have accelerated the search for new sources for inks. For this purpose, inks produced in the laboratory using a modified cellulose‐based binder, a commercial acrylic resin and a commercial soybean protein were compared with a commercial ink. As a result of the study, it was determined that the printability properties of the ink obtained by using the modified cellulose‐based binder were better than the ink obtained with commercial soybean protein. It was determined that it showed printability properties close to the ink produced with commercial acrylic binders. By using modified cellulose‐based water‐based flexographic ink instead of other commonly used binders, more environmentally friendly sustainable inks can be produced.
Combining neuroanatomical features to support diagnosis of fetal alcohol spectrum disorders
Authors: Fraize Justine , Garzón Pauline , Ntorkou Alexandra , Kerdreux Eliot , Boespflug‐Tanguy Odile , Beggiato Anita , Delorme Richard , Hertz‐Pannier Lucie , Elmaleh‐Berges Monique , Germanaud David 
Published: September 2022

AbstractAimTo identify easily accessible neuroanatomical abnormalities useful for diagnosing fetal alcohol spectrum disorders (FASD) in fetal alcohol syndrome (FAS) but more importantly for the probabilistic diagnosis of non‐syndromic forms (NS‐FASD).MethodWe retrospectively collected monocentric data from 52 individuals with FAS, 37 with NS‐FASD, and 94 paired typically developing individuals (6–20 years, 99 males, 84 females). On brain T1‐weighted magnetic resonance imaging, we measured brain size, corpus callosum length and thicknesses, vermis height, then evaluated vermis foliation (Likert scale). For each parameter, we established variations with age and brain size in comparison individuals (growth and scaling charts), then identified participants with abnormal measurements (<10th centile).ResultsAccording to growth charts, there was an excess of FAS with abnormally small brain, isthmus, splenium, and vermis. According to scaling charts, this excess remained only for isthmus thickness and vermis height. The vermis foliation was pathological in 18% of those with FASD but in no comparison individual. Overall, 39% of those with FAS, 27% with NS‐FASD, but only 2% of comparison individuals presented with two FAS‐recurrent abnormalities, and 19% of those with FAS had all three. Considering the number of anomalies, there was a higher likelihood of a causal link with alcohol in 14% of those with NS‐FASD.InterpretationOur results suggest that adding an explicit composite neuroanatomical–radiological criterion for FASD diagnosis may improve its specificity, especially in NS‐FASD.What this paper adds

Neuroanatomical anomalies independent of microcephaly can be measured with clinical‐imaging tools.
Small‐for‐age brain, small‐for‐brain‐size callosal isthmus or vermian height, and disrupted vermis foliation are fetal alcohol syndrome (FAS)‐recurrent anomalies.
Associations of these anomalies are frequent in fetal alcohol spectrum disorder (FASD) even without FAS, while exceptional in typically developing individuals.
These associations support higher likelihood of causal link with alcohol in some individuals with non‐syndromic FASD.
A new explicit and composite neuroanatomical–radiological criterion can improve the specificity of FASD diagnosis.
Influences of adding media additives on synthesis of gamma‐aminobutyric acid in fermentation of defatted rice bran extract with lactic acid bacteria
Authors: Lai Quoc Dat , Doan Ngoc Thuc Trinh , Nguyen Hoang Dung 
Published: September 2022

SummaryGamma‐aminobutyric acid (GABA), a main inhibitory neurotransmitter in brain, is a nonproteinogenic amino acid. The production of GABA from rice bran by lactic acid bacteria (Lactobacillus brevis) is an approach for maximising the potential of agricultural byproduct and reducing production cost. The use of media additives enhances the efficiency of GABA production, but their effects on cells and biomass in fermentation must be assessed to determine the appropriate concentration and efficiency. The influences of CaCl2 (0–1.5% w/v), Tween 80 (0–0.9% w/v), MnSO4 (0–0.6% w/v) and Pyridoxine hydrochloride (0–90 ppm) at different concentrations on GABA production by defatted rice bran extract fermentation using Lb. brevis VTCC‐B397 were evaluated. The changes in cell density, GABA content, reducing sugar content and pH value were observed. Consequently, the impact of media additive compounds on growth, development and GABA synthesis of Lb. brevis was demonstrated. Results showed that CaCl2, MnSO4 and Tween 80 positively affected GABA production from defatted rice bran extract by fermentation method.
Relations between white coat effect of blood pressure and arterial stiffness
Authors: Cao Rong , Yue Jianwei , Gao Ting , Sun Gang , Yang Xiaomin 
Published: September 2022

AbstractThe aim of this study was to analyze the relationship between brachial‐ankle pulse wave velocity (b‐a PWV) and white coat effect (WCE), that is the difference between the elevated office blood pressure (BP) and the lower mean daytime pressure of ambulatory BP, in a mixed population of normotention, untreated sustained hypertension, sustained controlled hypertension, sustained uncontrolled hypertension, white coat hypertension, white coat uncontrolled hypertension. A total of 444 patients with WCE for systolic BP (54.1% female, age 61.86 ± 13.3 years) were enrolled in the study. Patients were separated into low WCE (<9.5 mm Hg) and high WCE (≥9.5 mm Hg) according to the median of WCE. The subjects with a high WCE showed a greater degree of arterial stiffness than those with a low WCE for systolic BP values (P < .05). The b‐a PWV were 17.2 ± 3.3 m/s and 18.4 ± 3.4 m/s in low WCE and high WCE, respectively. The b‐a PWV increased with the increase of WCE, showing a positive correlation between them (P > .05 for non‐linearity). The significant association between the high WCE and the b‐a PWV was confirmed by the results of multiple regression analysis after adjusting for confounding factors (β = .78, 95% Cl .25‐1.31, P = . 004). Similar results were observed in subgroups. In conclusion, WCE is significantly associated with arterial stiffness. More research is needed to determine the WCE and target organ damage.
Prognostic value of tumor‐infiltrating immune cells in clinical early‐stage oral squamous cell carcinoma
Authors: Huang Zhengxian , Lu Yanwen , Wang Wenjin , Xie Nan , Yi Chen , Xiong Gan , Xu Xiuyun , Zhang Ming , Wang Cheng 
Published: September 2022

AbstractBackgroundTumor‐infiltrating immune cells (TIICs) are critical components of tumor immune microenvironment (TIME), which play crucial roles during tumor initiation, development, and progression. However, the prognostic value of TIICs is still not well documented in clinical early‐stage oral squamous cell carcinoma (OSCC). In this study, we aimed to assess the prognostic value of TIICs in clinical early‐stage OSCC and develop a nomogram based on TIICs to predict the prognosis.MethodsEighty patients with clinical early‐stage (cT1,2N0M0) OSCC were enrolled in this study. Immunohistochemical staining was performed to evaluate the infiltration of TIICs, including CD8+ T cells, CD57+ NK cells, CD163+ macrophage, and CD20+ B cells. Overall survival (OS) and disease‐free survival (DFS) curves were plotted by the Kaplan–Meier method. Cox's proportional hazards regression models were performed to assess the prognostic value of TIICs. Finally, a nomogram was established to predict the OS based on TIICs infiltration and assessed by concordance index (C‐index) and calibration curve.ResultsHigh infiltrations of CD57+ NK cells and CD20+ B cells indicated a better OS in clinical early‐stage OSCC. Moreover, high infiltration of CD20+ B cells favored a longer DFS. Of note, low infiltrations of CD57+ NK cells and CD20+ B cells were independent prognostic factors for poor OS in clinical early‐stage OSCC. The nomogram that combined CD57+ NK cells with CD20+ B cells could predict the OS in clinical early‐stage OSCC, and the C‐index was 0.801 (95% CI: 0.679–0.924). The calibration plot showed that prediction and observation are well matched.ConclusionsHigh infiltration of CD57+ NK cells and CD20+ B cells indicate a favorable OS in clinical early‐stage OSCC. The nomogram constructed based on TIICs might be used for predicting the prognosis in clinical early‐stage OSCC.
Can apps be used to formulate fluid therapy plans in veterinary medicine?
Authors: Zduoba Simona Aukse , House John , Rowe Sam 
Published: September 2022

AbstractBackgroundFormulating sophisticated fluid therapy plans can be complicated and time consuming. Consequently, veterinarians in the field who lack experience, time, or confidence may formulate suboptimal fluid therapy plans.ObjectivesCompare conventional and app‐guided fluid therapy plans for simulated cases of neonatal calf diarrhea.ParticipantsThird and fourth year veterinary students (n = 55) from The University of Sydney.MethodsWe developed a web app to assist fluid therapy formulation (http://calfaid.com) that was evaluated in a randomized case simulation trial. Participants were instructed to perform fluid therapy calculations and formulate an integrated fluid therapy plan for case scenarios using conventional methods and using the fluid therapy app. Responses were scored by a blinded study investigator using an a priori scoring guide and groups (conventional vs. app‐guided) were compared using linear mixed models.ResultsOn average, total scores for app‐guided fluid therapy calculations were 20.6% points higher (95% confidence interval [CI], 14.1‐27.1) than calculations completed using the conventional method (88.2% vs. 67.5%, respectively). On average, total scores for app‐guided integrated fluid therapy plans were 14.2% points higher (95% CI, 6.3‐22.2; 65.8% vs. 51.2%). Eighty percent of respondents indicated they would prefer to use the app‐guided method over the conventional method.Conclusion and Clinical ImportanceOur findings suggest that fluid therapy plans can be improved using apps.
Seasonality in hip fracture among haemodialysis patients and kidney transplant recipients in South Korea
Authors: Yoon Hye Eun , Lee Yeon Hee , Lee Joo Eun , Lee Jungkuk , Kim Hoseob , Chung Byung Ha , Shin Seok Joon 
Published: September 2022

AbstractAimThe seasonality of hip fracture in haemodialysis (HD) patients and kidney transplant recipients (KTRs) have not been reported. We assessed seasonal variations in hip fractures among patients with end‐stage kidney disease who undergo maintenance HD and KTRs.MethodsUsing the Korean National Health Insurance System database from January 2012 to December 2017, monthly counts of hip fracture were calculated among HD patients (n = 77 420) and KTRs (n = 8921). The 6‐year normalized monthly fraction and seasonal fractions of hip fractures were calculated. A cosinor analysis was performed to determine the seasonality of the monthly incidence of hip fractures.ResultsThe 6‐year average monthly fraction of hip fractures was lowest in June and highest in October in HD patients, and lowest in February and highest in November in KTRs. The 6‐year average seasonal fraction among HD patients was lowest in summer and highest in winter, and lowest in summer and highest in autumn among KTRs, but there was no significant difference. The incidence ratio of hip fractures was lowest in June and highest in January in HD patients, and lowest in August and highest in November in KTRs. On cosinor analysis, HD patients showed significant seasonality in hip fracture incidence, with a trough in summer and a peak in winter (p = .031), whereas KTRs did not exhibit a significant trend (p = .44).ConclusionHip fractures occurred more frequently in winter and less frequently in summer in patients undergoing HD, whereas KTRs did not show a seasonal trend.
Trajectory and determinants of agreement between parental and physicians' reports of childhood atopic dermatitis
Authors: Peng Zhuoxin , Braig Stefanie , Kurz Deborah , Weiss Johannes M. , Weidinger Stephan , Brenner Hermann , Rothenbacher Dietrich , Genuneit Jon 
Published: September 2022

AbstractBackgroundParent self‐administered reports are commonly used in studies on childhood atopic dermatitis (AD) but data on its validity are sparse. We aimed to examine the agreement between parent‐ and physician‐reported measures of childhood AD throughout early life and identify the determinants.MethodsIn this prospective cohort study, we used data of 449 infants and their mothers recruited in the Ulm SPATZ Health Study in Germany. Longitudinal data of parental and children's caring physicians' reports were used to assess the point and cumulative agreement of parent‐ and physician‐reported AD diagnoses, AD onset age, and trend of agreement at child ages between 1 and 6 years overall and by child and parent demographics and health conditions. A Generalized Estimating Equation model was fitted to identify factors associated with the sensitivity of parent reports.ResultsThe point agreement between parent‐ and physician‐reported AD was substantial at the age of 1 (kappa = 0.63, 95% CI: 0.51–0.75) but declined with age and became fair after the age of 3 (kappa < 0.40). The cumulative agreement remained moderate at the age of 6 (kappa = 0.51, 95% CI: 0.43–0.60). Parents had a bias towards delayed reporting of the AD onset age. The AD severity was the only strong determinant for the agreement of AD diagnoses and largely explained the variance of the sensitivity of parent reports.ConclusionThe disagreement between parent‐ and physician‐reported AD increases with child age, likely due to the change of AD severity. Using parent‐reported data might miss a substantial portion of mild childhood AD cases.
The weight of Wittgenstein's standard metre
Authors: Müller Thomas 
Published: September 2022

AbstractParagraph 50 of Wittgenstein'sPhilosophical Investigationsfamously says that there is one thing of which one can neither state that it is 1 m long nor that it isn't: the standard metre in Paris. Consensus appears to be that (1) exegetically speaking, Wittgenstein affirms this claim, and (2) systematically, whether or not one agrees with it, the practice of using a material artefact as a measurement standard has important philosophical consequences. In this paper, in contrast, we show that (1') Wittgenstein does not affirm the standard metre claim and (2') historical facts about material length standards do not warrant deeper philosophical conclusions. References to material measurement standards in the literature gravely distort the actual metrological practices of developing and using such standards.