bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artificial Intelligence Methods and Artificial Intelligence-Enabled Metrics for Surgical Education: A Multidisciplinary Consensus
Authors: Vedula S Swaroop , Ghazi Ahmed , Collins Justin W , Pugh Carla , Stefanidis Dimitrios , Meireles Ozanan , Hung Andrew J , Schwaitzberg Steven , Levy Jeffrey S , Sachdeva Ajit K ,   and the Collaborative for Advanced Assessment of Robotic Surgical Skills
Published: June 2022

BACKGROUND:
Artificial intelligence (AI) methods and AI-enabled metrics hold tremendous potential to advance surgical education. Our objective was to generate consensus guidance on specific needs for AI methods and AI-enabled metrics for surgical education.

STUDY DESIGN:
The study included a systematic literature search, a virtual conference, and a 3-round Delphi survey of 40 representative multidisciplinary stakeholders with domain expertise selected through purposeful sampling. The accelerated Delphi process was completed within 10 days. The survey covered overall utility, anticipated future (10-year time horizon), and applications for surgical training, assessment, and feedback. Consensus was agreement among 80% or more respondents. We coded survey questions into 11 themes and descriptively analyzed the responses.

RESULTS:
The respondents included surgeons (40%), engineers (15%), affiliates of industry (27.5%), professional societies (7.5%), regulatory agencies (7.5%), and a lawyer (2.5%). The survey included 155 questions; consensus was achieved on 136 (87.7%). The panel listed 6 deliverables each for AI-enhanced learning curve analytics and surgical skill assessment. For feedback, the panel identified 10 priority deliverables spanning 2-year (n = 2), 5-year (n = 4), and 10-year (n = 4) timeframes. Within 2 years, the panel expects development of methods to recognize anatomy in images of the surgical field and to provide surgeons with performance feedback immediately after an operation. The panel also identified 5 essential that should be included in operative performance reports for surgeons.

CONCLUSIONS:
The Delphi panel consensus provides a specific, bold, and forward-looking roadmap for AI methods and AI-enabled metrics for surgical education.
Effect of Metformin on HIF-1α Signaling and Postoperative Adhesion Formation
Authors: Biller Marvin L , Tuffs Christopher , Bleul Marc , Tran Dinh Thien-An , Dupovac Mareen , Keppler Ulrich , Harnoss Jonathan M , Probst Pascal , Schneider Martin , Strowitzki Moritz J 
Published: June 2022

BACKGROUND:
Peritoneal adhesion formation is common after abdominal surgery and results in severe complications. Tissue hypoxia is one of the main drivers of peritoneal adhesions. Thus, we determined the clinical role of hypoxia-inducible factor (HIF)-1 signaling in peritoneal adhesions and investigated whether the biguanide antidiabetic drug metformin shows HIF-inhibitory effects and could be repurposed to prevent adhesion formation.

STUDY DESIGN:
As part of the ReLap study (DRKS00013001), adhesive tissue from patients undergoing relaparotomy was harvested and graded using the adhesion grade score. HIF-1 signaling activity within tissue biopsies was determined and correlated with adhesion severity. The effect of metformin on HIF-1 activity was analyzed by quantification of HIF target gene expression and HIF-1 protein stabilization in human mesothelial cells and murine fibroblast under normoxia and hypoxia. Mice were treated with vehicle or metformin 3 days before and until 7 days after induction of peritoneal adhesions; alternatively, metformin treatment was discontinued 48 hours before induction of peritoneal adhesions.

RESULTS:
HIF-1 signaling activity correlated with adhesion severity in patient biopsies. Metformin significantly mitigated HIF-1 activity in vitro and in vivo. Oral treatment with metformin markedly prevented adhesion formation in mice even when the treatment was discontinued 48 hours before surgery. Although metformin treatment did not alter macrophage polarization, metformin reduced proinflammatory leucocyte infiltration and attenuated hypoxia-induced profibrogenic expression patterns and myofibroblast activation.

CONCLUSIONS:
Metformin mitigates adhesion formation by inhibiting HIF-1-dependent (myo)fibroblast activation, conferring an antiadhesive microenvironment after abdominal surgery. Repurposing the clinically approved drug metformin might be useful to prevent or treat postoperative adhesions.
Impact of Clinician Linkage on Unequal Access to High-Volume Hospitals for Colorectal Cancer Surgery
Authors: McDermott James , Wang Haijun , DeLia Derek , Sweeney Matthew , Bayasi Mohammed , Unger Keith , Stein David E , Al-Refaie Waddah B 
Published: June 2022

BACKGROUND:
Understanding drivers of persistent surgical disparities remains an important area of cancer care delivery and policy. The degree to which clinician linkages contribute to disparities in access to quality colorectal cancer surgery is unknown. Using hospital surgical volume as a proxy for quality, the study team evaluated how clinician linkages impact access to colorectal cancer surgery at high-volume hospitals (HVHs).

STUDY DESIGN:
Maryland’s Health Services Cost Review Commission was used to evaluate 6,909 patients who underwent colon or rectal cancer operations from 2013 to 2018. Two linkages based on patient sharing were examined separately for colon and rectal cancer surgery: (1) from primary care clinicians to specialists (gastroenterologist or medical oncologist) and (2) from specialists to surgeons (general or colorectal). A referral link was defined as 9 or more shared patients between 2 clinicians. Adjusted regression models examined associations between referral links and odds of receiving colon or rectal cancer operations at HVHs.

RESULTS:
The cohort included 5,645 colon and 1,264 rectal cancer patients across 52 hospitals. Every additional referral link between a primary care clinician and a specialist connected to a HVH was associated with a 12% and 14% increased likelihood of receiving colon (odds ratio [OR] 1.12, CI 1.07 to 1.17) and rectal (OR 1.14, CI 1.08 to 1.20]) cancer operations at a HVH, respectively. Every additional referral link between a specialist and a surgeon at a HVH was associated with at least a 25% increased likelihood of receiving colon (OR 1.28, CI 1.20 to 1.36) and rectal (OR 1.25, CI 1.15 to 1.36) cancer operation at a HVH.

CONCLUSIONS:
Patients of clinicians with linkages to HVHs are more likely to have their colorectal cancer operations at these hospitals. These findings suggest that policy interventions targeting clinician relationships are an important step in providing equitable surgical care.
Disparity in Transport of Critically Injured Patients to Trauma Centers: Analysis of the National Emergency Medical Services Information System (NEMSIS)
Authors: Escobar Natalie , DiMaggio Charles , Frangos Spiros G , Winchell Robert J , Bukur Marko , Klein Michael J , Krowsoski Leandra , Tandon Manish , Berry Cherisse 
Published: June 2022

BACKGROUND:
Patient morbidity and mortality decrease when injured patients meeting CDC Field Triage Criteria (FTC) are transported by emergency medical services (EMS) directly to designated trauma centers (TCs). This study aimed to identify potential disparities in the transport of critically injured patients to TCs by EMS.

STUDY DESIGN:
We identified all patients in the National EMS Information System (NEMSIS) database in the National Association of EMS State Officials East region from January 1, 2018, to December 31, 2019, with a final prehospital acuity of critical or emergent by EMS. The cohort was stratified into patients transported to TCs or non-TCs. Analyses consisted of descriptive epidemiology, comparisons, and multivariable logistic regression analysis to measure the association of demographic features, vital signs, and CDC FTC designation by EMS with transport to a TC.

RESULTS:
A total of 670,264 patients were identified as sustaining an injury, of which 94,250 (14%) were critically injured. Of those 94,250 critically injured, 56.0% (52,747) were transported to TCs. Among all critically injured women (n = 41,522), 50.4% were transported to TCs compared with 60.4% of critically injured men (n = 52,728, p < 0.001). In a multivariable logistic regression model, critically injured women were 19% less likely to be taken to a TC compared with critically injured men (OR 0.81, 95% CI 0.71–0.93, p = 0.003).

CONCLUSIONS:
Critically injured female patients are less likely to be transported to TCs when compared with their male counterparts. Performance improvement processes that assess EMS compliance with field triage guidelines should explicitly evaluate for sex-based disparities. Further studies are warranted.
Building an RNA switch-based selection system for enzyme evolution in yeast
Authors: Kong Deze , Smolke Christina 
Published: June 2022

ABSTRACTRecent advances in synthetic biology and metabolic engineering have enabled yeast as a favorable platform for synthesis of valuable natural and semi-synthetic compounds through expression of multiple heterologous enzymes sourced from plants, fungi and bacteria. However, these heterologous enzymes can suffer from low activity, specificity, stability and solubility in yeast, resulting in arduous iterations of design-build-test-learn cycles to optimize their production often performed on a single enzyme basis. Laboratory directed evolution has proven to be a powerful and high-throughput method for protein engineering, albeit its limited application for biosynthetic enzymes. Here, we harness small molecule-sensing, RNA-based switches to develop a generalizable selection system facilitating enzyme evolution. Our design utilizes an RNA-based switch for detection of intracellular compound production, which then regulates the expression of a selection gene. Our initial data shows that the auxotrophy selection gene SpHIS5 exhibits the highest selective capability in combination with a theophylline-responsive RNA-based switch. Using the theophylline-responsive RNA-based switch, we demonstrated the enrichment of a high-producing variant of caffeine demethylase, in a population size of 103. We target to demonstrate the use of this RNA-based selection system as a general approach for enzyme evolution.
GWAS identifies candidate genes controlling adventitious rooting in Populus trichocarpa
Authors: Nagle Michael F. , Yuan Jialin , Kaur Damanpreet , Ma Cathleen , Peremyslova Ekaterina , Jiang Yuan , Willig Christopher J. , Goralogia Greg S. , de Rivera Alexa Niño , McEldowney Megan , Goddard Amanda , Magnuson Anna , Muchero Wellington , Fuxin Li , Strauss Steven H. 
Published: June 2022

AbstractAdventitious rooting is critical to the propagation, breeding, and genetic engineering or editing of trees. The capacity for plants to undergo these processes is highly heritable; however, the basis of its genetic variation is largely uncharacterized. To identify genetic regulators of these processes, we performed a genome-wide association study (GWAS) using 1,148 genotypes of Populus trichocarpa. GWAS are often limited by the abilities of researchers to collect precise phenotype data on a high-throughput scale; to help overcome this limitation, we developed a computer vision system to measure an array of traits related to adventitious root development in poplar, including temporal measures of lateral and basal root length and area. GWAS was performed using multiple methods and significance thresholds to handle non-normal phenotype statistics, and to gain statistical power. These analyses yielded a total of 277 unique associations, suggesting that genes that control rooting include regulators of hormone signaling, cell division and structure, and reactive oxygen species signaling. Genes related to other processes with known roles in root development, and numerous genes with uncharacterized functions and/or cryptic roles, were also identified. These candidates provide targets for functional analysis, including physiological and epistatic analyses, to better characterize the complex polygenic regulation of adventitious rooting.
Influence of cryogenic impacting and succeeding annealing on electrochemical corrosion behavior of coarse-grain Cu bulk in sodium chloride solution
Authors: Zhu Jun , Luo Wei , Xv Wentao , Xv Shuigen , Zhang XinYang , Zhao Jiefang 
Published: June 2022

Purpose
This paper aims to study the electrochemical corrosion performance of ultrafine-grained (UFG) Cu bulk in 0.5 M NaCl solution.

Design/methodology/approach
UFG Cu bulk were prepared by impacting at −196°C and following heat treatment. The electrochemical corrosion behaviors of coarse-grained (CG), impacted and subsequently annealed at 190°C Cu bulks were studied.

Findings
All the bulks displayed typical active-passive-transpassive behaviors (dual passive films without stable passive regions). The resistance to corrosion of impacted Cu bulk was notably superior to that of CG Cu bulk, and subsequently annealing further improved its corrosion resistance.

Social implications
Except for mechanical properties, corrosion performance has been considered to be one of the most important aspects in bulk UFG metallic materials research for the prospective engineering applications.

Originality/value
Cryogenic impacting could effectively reduce grain size of CG Cu bulk to UFG scale and induce high density dislocation. Subsequent annealing resulted in a further decrease of grain size even to nanoscale, as well as nanometer twins. The grain refinement, high density dislocation and annealing twins effectively enhance the passivation capability, resulting in an increase in the corrosion resistance.
Attitude control and laser link acquisition strategy for a large-scale distributed satellite system with super long distance
Authors: Han Yaquan , Wang Jihe , Huang Haifeng , Sun Jun , Sun Yue 
Published: June 2022

Purpose
This study aims to establish the laser links between satellites among large-scale distributed satellite systems; a combined attitude control strategy containing two stages is proposed in this paper.

Design/methodology/approach
These two stages are: one is the attitude initial pointing control to change the attitude of satellite pointing to the other satellite based on the position information of each satellite; the other one is the high precision attitude tracking control to scan the uncertainty cone because the initial pointing control accuracy is not enough to establish the laser link. At the initial pointing control stage, a method to determine the target attitude of each satellite is presented based on the position information of each satellite, and the fuzzy adaptive control algorithm is used to control the satellites to its calculated attitude. Then, at the high precision attitude tracking control stage, a strategy for laser link acquisition and scanning the uncertainty cone by the lasers of the spacecraft is proposed, and an angular velocity tracking scanning controller is designed while the convergence of the attitude tracking error is ensured through Lyapunov–Krasovskii theory.

Findings
Simulations are conducted to verify the effectiveness of the proposed control algorithm, and the laser link for a large-scale distributed satellite system with super long distance is achieved through a combined attitude control strategy.

Research limitations/implications
A combined attitude control strategy is valid for a large-scale distributed satellite system with super long distance.

Practical implications
A combined attitude control strategy can be used to achieve laser link acquisition for a large-scale distributed satellite system like space gravitational wave detection.

Originality/value
A combined attitude control strategy can provide a way to solve the typical problem that pointing control accuracy is not enough to establish the laser link for a large-scale distributed satellite system.
The effect of social support on job performance through organizational commitment and innovative work behavior: does innovative climate matter?
Authors: Vuong Bui Nhat , Tushar Hasanuzzaman , Hossain Syed Far Abid 
Published: June 2022

PurposeThe purpose of this study is to explore the influence of social support (SS) on job performance (JP) through the mediating role of organizational commitment (OC) and innovative work behavior (IWB) as well as the moderating role of innovative climate (IC).Design/methodology/approachThe present research used a self-report questionnaire from a sample of 694 full-time employees in the Vietnamese small and medium-sized enterprises (SMEs) and the partial least squares structural equation modeling (PLS-SEM) to test studied hypotheses.FindingsThe findings revealed that a high level of social support at work could enhance employees’ job performance. The findings also indicated that this positive relationship was partially mediated by organizational commitment and innovative work behavior. Besides, an innovative climate strengthened the positive association between social support and innovative work behavior.Practical implicationsThe result of this study provides practical implications for the contemporary human resource (HR) management practice and policy in organizations. Organizations may have an enduring HR policy to strengthen robust social support to enhance employees’ job performance at work.Originality/valuePerhaps, the largest benefit of this research is that the research provided statistical evidence of the relational values between a system of variables to add to the limited academic literature available on the subject. While plenty of literature suggested that social support played a crucial role in organizational commitment, innovative work behavior, and job performance, the researchers failed to determine if a moderating role of innovative climate existed between social support and innovative work behavior. This study filled the gap in literature by introducing that a moderation exists of IC between SS and IWB instead of using SS and IWB as separate factors.
Evaluating water sorption isotherms, drying kinetics and exergy performance of traditionally earth mortar drying system based on hybrid solar-electrical dryer
Authors: Kouhila Mounir , Bahammou Younes , Lamsyehe Hamza , Tagnamas Zakaria , Moussaoui Haytem , Idlimam Ali , Lamharrar Abdelkader 
Published: June 2022

PurposeThe paper aims to evaluate drying performance of earth mortar by solar drying for more durability, minimize pathologies in traditional construction and determine the influence of temperature and humidity on the microstructure of earth mortar using static gravimetric method.Design/methodology/approachA convective solar dryer was used for the pretreatment of building and solid materials for construction.FindingsThe humidity influences the mortar sorption – surface water sorption of earth mortar increased with increasing temperature.Originality/valueThe study used a novel method for pretreatment building materials by using solar dryer.
Effect of leadership and quality culture on quality management practices and operational performance of construction companies in Oman
Authors: Khalfan Issa , Jamaluddin Zaharuzaman , Widyarto Setyawan 
Published: June 2022

PurposeConstruction companies play a vital role in the development of any country. The objective of the study is to evaluate the influence of leadership and quality culture (QC) on quality management (QM) practices and operational performance (OP).Design/methodology/approachThe questionnaire method was used to collect raw data from 325 construction companies in Oman. Confirmatory factor analysis was applied to evaluate the measurement, model reliability and validity. The relationship between the latent constructs was investigated by Partial Least Square – Structural Equation Modeling (PLS-SEM).FindingsThe findings indicate that, leadership significantly affected QM practices and OP. Moreover, while the QC has significantly influenced QM practices, QC had not influenced OP. One reason is the lack of knowledge of the employee that the quality procedures have the power to reduce rework, waste, and decrease the project's period. And the study found that the QM practices have significantly influenced OP.Research limitations/implicationsThe limitation of this research is that some construction companies have no quality assurance leaders in the project; therefore, the questionnaires were circulated to project managers or project management leaders and that negatively affect the quality of data collecting from the responses. Eventually, the framework is considered to be the main contribution and is recommended for usage in the project. This study gives guidelines for leadership and leadership's accountabilities to provide a keen decision that to improve OP and to ensure the competence of employees.Originality/valueThe limitation of this research is that some construction companies have no quality assurance leaders in the project and so the questionnaires were circulated to project managers or project management leaders, which could influence the value of the responses. Eventually, the framework appeared to be the main contribution to awareness and is recommended for use to ensure a successful construction project in both the public and private sectors. The current study lays out some relevant roles for leadership and its accountabilities to provide a keen decision to improve OP and to ensure the competence of employees.
Class or individual habitus? Willingness to spend more on reconciliation policies in Europe
Authors: Doblytė Sigita , Tejero Aroa 
Published: June 2022

PurposePublic willingness to pay for extra public benefits and services may demonstrate a tension between the common good (more services) and economic motives (higher taxes for all). In this article, the authors present an analysis of this trade-off by drawing upon the Bourdieusian theory of social reproduction and habitus.Design/methodology/approachEmploying the European Social Survey (2016), the authors first examine the patterns of relationships between the agents' position in the social structure and their attitudes across care regimes in Europe. The authors then analyse whether this link is mediated by agents' individual trajectories and dispositions, such as their beliefs towards equality or tradition, political orientation, or religiosity.FindingsThe findings support the importance of both sociation and individuation in habitus formation, albeit to varying degrees across the regimes. Individual attitudes are therefore shaped not only by interests of reproducing or maximising social positions but also by more reflexive propensities to think about the common good.Originality/valueIn this article, the authors draw upon the theory of social reproduction and habitus by Pierre Bourdieu, who has been thus far rarely employed in the study of welfare attitudes. The article also contributes to the literature that studies the trade-off between the expansion and financing of reconciliation policies.