bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of brain serotonin deficiency on breathing is magnified by age
Authors: Pho Huy , Amorim Mateus R. , Qiu Qingchao , Shin Mi‐Kyung , Kim Lenise J. , Anokye‐Danso Frederick , Jun Jonathan J. , Ahima Rexford S. , Branco Luiz G. S. , Kuhn Donald M. , Mateika Jason H. , Polotsky Vsevolod Y. 
Published: May 2022

AbstractSerotonin is an important mediator modulating behavior, metabolism, sleep, control of breathing, and upper airway function, but the role of aging in serotonin‐mediated effects has not been previously defined. Our study aimed to examine the effect of brain serotonin deficiency on breathing during sleep and metabolism in younger and older mice. We measured breathing during sleep, hypercapnic ventilatory response (HCVR), CO2 production (VCO2), and O2 consumption (VO2) in 16–18‐week old and 40–44‐week old mice with deficiency of tryptophan hydroxylase 2 (Tph2), which regulates serotonin synthesis specifically in neurons, compared to Tph2+/+ mice. As expected, aging decreased VCO2 and VO2. Tph2 knockout resulted in an increase in both metabolic indexes and no interaction between age and the genotype was observed. During wakefulness, neither age nor genotype had an effect on minute ventilation. The genotype did not affect hypercapnic sensitivity in younger mice. During sleep, Tph2−/− mice showed significant decreases in maximal inspiratory flow in NREM sleep, respiratory rate, and oxyhemoglobin saturation in REM sleep, compared to wildtype, regardless of age. Neither serotonin deficiency nor aging affected the frequency of flow limited breaths (a marker of upper airway closure) or apneas. Serotonin deficiency increased the amount and efficiency of sleep only in older animals. In conclusion, younger Tph2−/− mice were able to defend their ventilation and phenotypically did not differ from wildtype during wakefulness. In contrast, both young and old Tph2−/− mice showed sleep‐related hypoventilation, which was manifested by hypoxemia during REM sleep.
Effects of chemical-based fertilizer replacement with biochar-based fertilizer on albic soil nutrient content and maize yield
Authors: Yin Dawei , Yang Xiangyu , Wang Haize , Guo Xiaohong , Wang Shiqiang , Wang Zhihui , Ding Guohua , Yang Guang , Zhang Jianing , Jin Liang , Lan Yu 
Published: May 2022

Abstract
Biochar-based fertilizers are used to improve soil’s physiochemical and biological properties and increase fertilizer utilization rate. Therefore, a technological model of biochar-based fertilizers is essential for the reduced application. This study was conducted to determine the effects of the different levels of biochar-based fertilizer applications on soil and plant nutrient content, as well as maize yield. Biochar-based fertilizer increased the total N content of maize stem and kernel and the total P content of maize axis and kernel. Biochar-based fertilizer increased the total P but decreased the total K of maize plants while increasing the fertilizer’s partial productivity. Treatment B1 (600.00 kg hm−2 of biochar-based fertilizer) increased the dry-matter weight of the maize at silking and filling stages by 1.60 and 15.83%. Treatment B1 increased the ear length, diameter, and plant height. Compared with BCK (600.00 kg hm−2 of conventional fertilizer), the yield of B1 was increased by 9.23%, and the difference was significant (p < 0.05). Biochar-based fertilizer treatments B2–B5 (biochar-based fertilizer reduced by 5–20%) reduced maize yield, but there was no significant difference between their yield and BCK. This study aimed to provide a basic understanding and reference for maize fertilizer reduction with good application prospects.
The stopped clock model
Authors: Ferreira Helena , Ferreira Marta 
Published: May 2022

Abstract
The extreme value theory presents specific tools for modeling and predicting extreme phenomena. In particular, risk assessment is often analyzed through measures for tail dependence and high values clustering. Despite technological advances allowing an increasingly larger and more efficient data collection, there are sometimes failures in the records, which causes difficulties in statistical inference, especially in the tail where data are scarcer. In this article, we present a model with a simple and intuitive failures scheme, where each record failure is replaced by the last record available. We will study its extremal behavior with regard to local dependence and high values clustering, as well as the temporal dependence on the tail.
Improvement of buckwheat noodles quality via differential pressure explosion puffing (DPEP): cooking and structural quality
Authors: Li Shuhong , Niu Haili , Gao Ying , Kan Zhuorui , Jiang Lan , Li Xiuxiu , Chen Ye 
Published: May 2022

Abstract
In order to improve the poor formability and taste, a method of buckwheat noodles via differential pressure explosion puffing (DPEP) pre-gelatinization was developed. The effects of DPEP on gelatinization properties of buckwheat flour was investigated. The textural properties, sensory evaluation, cross section morphology, crystal structure, thermodynamic properties and simulated digestion in vitro of buckwheat noodles were characterized. The results indicated that DPEP treatment was beneficial for the texture properties and sensory evaluation, while the cooking loss rate and broken rate of noodles were reduced to 16.31% and 6.28%. The crystal structure of starch in noodles pretreated via DPEP form a more compact structure and enhanced the water holding capacity. DPEP reduced the digestibility in vitro of the noodles. The level of rapidly digestible starch reduced to 15.6%, slowly digestible starch and resistant starch increased to 21.6% and 62.8%, which made the buckwheat noodles have potential to improve health of diabetics.
The effect of using different fibres on the impact-resistance of slurry infiltrated fibrous concrete (SIFCON)
Authors: Jerry Ali Hassan , Fawzi Nada Mahdi 
Published: May 2022

Abstract
Slurry infiltrated fibrous concrete (SIFCON) is a modern type of fibre reinforced concrete (FRC). It has unique properties; SIFCON is superior in compressive strength, flexural strength, tensile strength, impact resistance, energy absorption and ductility. Because of this superiority in these characteristics, SIFCON was qualified for applications of special structures, which require resisting sudden dynamic loads such as explosions and earthquakes. The main aim of this investigation is to determine the effect of fibre type on the apparent density of SIFCON and on performance under impact load. In this investigation, hook-end steel fibre and polyolefin fibre were used. Purely once and hybrid in different portions again. After reviewing previous research, including [1, 2, 3] references three trail mixes were tested with a volume fraction of fibres (4, 6 and 8)%, and after testing them, a volume fraction of 6% was chosen. We chose the volume fraction of 6% and made the type of fibre the variable for comparison in this research. In hybrid fibres this fraction was divided once 2/3 steel fibres with 1/3 polyolefin fibres and vice versa. The specimens of the Impact resistance test were made with two specimens for each series, which are panels with dimensions of 50×50×5 cm. Three cubes were made for each series in the SIFCON apparent density test. Test results prove SIFCON produced from 2/3 polyolefin and 1/3 steel fibres achieved a good density reduction that contributes to reducing the self-weight of the structural element, which is a major aim in this investigation, reducing cost and maintaining high impact resistance.
Thinking with Faith, Thinking as Faith: What Comes After Onto-theo-logy?
Authors: Caputo John D. 
Published: May 2022

Abstract
Despite Heidegger’s constant claims to the contrary, thinking is not opposed to faith. Indeed, against his own intentions, Heidegger’s critique of onto-theo-logy, which breaks the grip of modernity, issues in a faith more radically conceived. This faith is the thinking, this thinking is the faith that becomes possible in the post-secular space which Heidegger’s critique of modernity opens. Although the great medieval theologians like Augustine and Aquinas are not onto-theo-logians in a strict sense, they, along with the whole history of metaphysics, fall under its wider sense of any centered and foundational discourse. But any discourse that eludes onto-theo-logy in the wider sense finds itself embracing a faith, not reducible to belief, where thinking is a form of faith and faith is a form of thinking. Derrida’s “Circumfession,” a paradigmatic post-ontotheological discourse, is a work of prayer and a confession of faith in the open-endedness of the event, an un-programmable future (à venir). This text communicates with Heidegger thinking the “open,” the “promise” of language, of the Zukunft embedded in the Herkunft, constituting the “piety of thinking.”
Application of organic gas steam-liquid extraction system for extraction and separation of uranium from water samples as a new efficient method
Authors: Sharifkhani Samira M. , Yaftian Mohammad Reza , Hosseini Majid Haji , Zolfonoun Ehsan , Kakaei Saeed 
Published: May 2022

Abstract
In this study, for the first time the organic gas steam-liquid extraction (OGS-LE) method is used as a simple, efficient and scalable to industrial application technique for the extraction and separation of uranium (VI) from aqueous samples. OGS-LE is done by a special handmade extraction cell. In this method, the organic solvent vapor produced in the evaporator unit is introduced into the aqueous sample by using nitrogen as a carrier gas. By inserting the vapor bubbles of the organic solvent into the aqueous sample, the organic solvent dissolves in water and the organic solvent concentration in water reaches supersaturation. During this process, equilibrium occurs between the dissolved organic solvent and the insoluble organic solvent, and it is collected on top of the aqueous phase. Uranium has been extracted with cyanex 272 and tetrabutylammonium bromide (TBAB) as extractant into n-heptane from the alkaline aqueous media by the OGS-LE method. Cyanex 272 and TBAB were used as the complexing ligand and the ion pairing reagent, respectively. The mechanism of extraction was proposed depending on the deprotonating of cyanex 272 and ionic interaction with the quaternary ammonium bases. Face Central Composite Design (FCCD) was used to evaluate the effect of various factors. Under the optimized conditions, uranium extraction could be completed in a single stage with the extraction efficiency of more than 90% from an aqueous solution containing alkali, alkaline Earth and transition metal ions. The precision, obtained by performing five replicates under the optimized conditions, was 90.12% ± 0.75% (percentage of extraction ± RSD).
Extracted saponin from Anabasis setifera plant as a biosurfactant for stabilization of oil in water (O/W) nano-emulsion based on date palm (Phoenix dactylifera) kernel oil
Authors: Rigi Fatemeh 
Published: May 2022

Abstract
Saponin was extracted from the Anabasis setifera plant and used to stabilize an oil-in-water (O/W) emulsion based on date palm kernel oil. Different amounts of the extracted saponin were used with a constant oil concentration (1.5% w/w). The droplet size distribution, emulsion droplet size value (d-ave), polydispersity index (PDI) and zeta potential of the emulsions were determined using dynamic light scattering (DLS). These parameters were measured and compared after seven days of emulsion preparation. The best results (d-ave = 41.7 nm, PDI = 0.1 and zeta potential = −29.8 mV) were obtained for the CMC of saponin. Both the oil and the surfactant were specifically extracted and used from the nature of Saravan in the Baluchestan region of Iran. This research presents a green and cost-effective aspect for potential formulations of nano-emulsions that can be used in the food and cosmetic industries.
Die Prädialisten (kirchlichen Edlen) des Kapitels Wesprim im 14. Jahrhundert
Authors: Farkas Péter 
Published: May 2022

The nobles of the Church of the chapter of Veszprém in the fourteenth century
The purpose of this article is the discussion of the nobles of the Church belonging to the chapter of Veszprém (in Veszprém, Somogy and Zala counties) in the 13th–14th centuries with regard to taxation, litigation and landholding. For most of time, these nobles of the Church initially came from the estates of the Church itself but later they arrived in large numbers from outside the institutional framework of the majority. Legal and economic differences can be detected among the nobles of the Church.
Der Einfluss der Papsturkunden auf die Schreiben der päpstlichen delegierten Richter in Ungarn in der ersten Hälfte des 13. Jahrhunderts
Authors: Barabás Gábor 
Published: May 2022

The influence of papal mandates on the charters of Hungarian papal judge-delegates in the first half of the thirteenth century
The paper is a short contribution to the research on the influence that papal literacy exerted on the charters of Hungarian papal judge-delegates in the first half of the 13th century. The main aim of this topic is to identify how and to what extent the characteristics of papal mandates were reflected in the phrases of the relevant Hungarian documents. Furthermore, is it also important to examine how the delegates expressed the importance of their papal authorisation.
Causae coram nobis ventilatae
Authors: Kovács Viktória 
Published: May 2022

Causae coram nobis ventilatae. Contributions to the ecclesiastical jurisdiction of the papal legate, Gentilis de Monteflorum (1308–1311)
This paper provides a contribution to the history of papal legations in Hungary at the beginning of the 14th century. The main aim of the study is to introduce the ecclesiastical jurisdiction of the cardinal-legate, Gentilis de Monteflorum in Hungary in the period (1308–1311) and identify the existence or the absence of a systematic case managing. Especially important are in this respect the types of cases, their nature, significance, and the delegated clericals who were committed to decide these cases.
Aging-Associated Cognitive Decline is Reversed by D-Serine Supplementation
Authors: Nava-Gómez L. , Calero-Vargas I. , Higinio-Rodríguez F. , Vázquez-Prieto B. , Olivares-Moreno R. , Ortiz-Retana J. , Aranda P. , Hernández-Chan N. , Rojas-Piloni G. , Alcauter S. , López-Hidalgo M. 
Published: May 2022

AbstractBrain aging is a natural process that involves structural and functional changes that lead to cognitive decline, even in healthy subjects. This detriment has been associated with NMDA receptor (NMDAR) hypofunction because of a reduction in the brain levels of D-serine, the endogenous NMDAR co-agonist. However, it is not clear whether D-serine supplementation could be used as an intervention to reduce or reverse age-related brain alterations. In the present work, we aimed to analyze the D-serine effect on aging-associated alterations in cellular and large-scale brain systems that could support cognitive flexibility in rats. We found that D-serine supplementation reverts the age-related decline in cognitive flexibility, frontal dendritic spine density, and partially restored large-scale functional connectivity without inducing nephrotoxicity; instead, D-serine restored the thickness of the renal epithelial cells that were affected by age. Our results suggest that D-serine could be used as a therapeutic target to reverse age-related brain alterations.
Comparing Surrogates to Evaluate Precisely Timed Higher-Order Spike Correlations
Authors: Stella Alessandra , Bouss Peter , Palm Günther , Grün Sonja 
Published: May 2022

AbstractThe generation of surrogate data, i.e., the modification of data to destroy a certain feature, can be considered as the implementation of a null-hypothesis whenever an analytical approach is not feasible. Thus, surrogate data generation has been extensively used to assess the significance of spike correlations in parallel spike trains. In this context, one of the main challenges is to properly construct the desired null-hypothesis distribution and to avoid altering the single spike train statistics. A classical surrogate technique is uniform dithering (UD), which displaces spikes locally and uniformly distributed, to destroy temporal properties on a fine timescale while keeping them on a coarser one. Here, we compare UD against five similar surrogate techniques in the context of the detection of significant spatiotemporal spike patterns. We evaluate the surrogates for their performance, first on spike trains based on point process models with constant firing rate, and second on modeled nonstationary artificial data to assess the potential detection of false positive (FP) patterns in a more complex and realistic setting. We determine which statistical features of the spike trains are modified and to which extent. Moreover, we find that UD fails as an appropriate surrogate because it leads to a loss of spikes in the context of binning and clipping, and thus to a large number of FP patterns. The other surrogates achieve a better performance in detecting precisely timed higher-order correlations. Based on these insights, we analyze experimental data from the pre-/motor cortex of macaque monkeys during a reaching-and-grasping task.
Telomere length and Wnt/β-catenin pathway in adamantinomatous craniopharyngiomas
Authors: Mota Jose Italo Soares , Silva-Júnior Rui Milton Patrício , Martins Clarissa Silva , Bueno Ana Carolina , Wildemberg Luiz Eduardo , Antunes Ximene Lima da Silva , Ozaki Jorge Guilherme Okanobo , Coeli-Lacchini Fernanda Borchers , Garcia-Peral Carlos , Oliveira Antonio Edson Rocha , Santos Antônio Carlos , Moreira Ayrton Custodio , Machado Helio Rubens , dos Santos Marcelo Volpon , Colli Leandro M , Gadelha Monica R , Antonini Sonir Roberto R , de Castro Margaret 
Published: May 2022

Abstract

Objectives
To evaluate how telomere length behaves in adamantinomtous craniopharyngioma (aCP) and if it contributes to the pathogenesis of aCPs with and without CTNNB1 mutations.

Design
Retrospective cross-sectional study enrolling 42 aCP patients from 2 tertiary institutions.

Methods
Clinicopathological features were retrieved from the patient's charts. Fresh frozen tumors were used for RNA and DNA analyses. Telomere length was evaluated by qPCR (T/S ratio). Somatic mutations in TERT promoter (TERTp) and CTNNB1 were detected by Sanger and/or whole-exome sequencing. We performed RNA-Seq to identify differentially expressed genes in aCPs presenting with shorter or longer telomere lengths.

Results
Mutations in CTNNB1 were detected in 29 (69%) tumors. There was higher frequency of CTNNB1 mutations in aCPs from patients diagnosed under the age of 15 years (85% vs 15%; P = 0.04) and a trend to recurrent disease (76% vs 24%; P = 0.1). No mutation was detected in the TERTp region. The telomeres were shorter in CTNNB1-mutated aCPs (0.441, IQR: 0.297–0.597vs 0.607, IQR: 0.445–0.778; P = 0.04), but it was neither associated with clinicopathological features nor with recurrence. RNAseq identified a total of 387 differentially expressed genes, generating two clusters, being one enriched for short telomeres and CTNNB1-mutated aCPs.

Conclusions
CTNNB1 mutations are more frequent in children and adolescents and appear to associate with progressive disease. CTNNB1-mutated aCPs have shorter telomeres, demonstrating a relationship between the Wnt/β-catenin pathway and telomere biology in the pathogenesis of aCPs.
¿Hemos progresado?
Authors: Mesa Duque Clara Cecilia 
Published: May 2022

CELEBRACIÓN DE LOS VEINTE AÑOS DE DESDE EL JARDÍN DE FREUD
¿Por qué escribir hoy Desde el Jardín de Freud?
El día 9 de octubre del 2020, en medio del primer año de la pandemia, tuvimos ocasión de presentar el número 20 de la revista Desde el Jardín de Freud. En la distancia, nos acercamos a nuestros lectores y colaboradores no solo para presentar el número dedicado a los “Cálculos del discurso: lo inconsciente y la política”, sino para decir de nueva manera el espíritu que anima esta publicación. Decidimos entonces invitar a tres de nuestros colaboradores cuyas contribuciones siempre han abierto horizontes de elaboración novedosos. Una sola y única pregunta les formulamos a Nieves Soria Dafunchio, Clara Cecilia Mesa y Marie-Jean Sauret:
“¿Por qué escribir hoy Desde el Jardín de Freud?”.
Esta sección reúne las repuestas que cada uno presentó en aquella ocasión.

Para ver la jornada completa siga el enlace: https://youtu.be/Amu6Tk-RY-Q
Escribir hoy en día: ¿síntoma de qué?
Authors: Sauret Marie-Jean 
Published: May 2022

CELEBRACIÓN DE LOS VEINTE AÑOS DE DESDE EL JARDÍN DE FREUD
¿Por qué escribir hoy Desde el Jardín de Freud?
El día 9 de octubre del 2020, en medio del primer año de la pandemia, tuvimos ocasión de presentar el número 20 de la revista Desde el Jardín de Freud. En la distancia, nos acercamos a nuestros lectores y colaboradores no solo para presentar el número dedicado a los “Cálculos del discurso: lo inconsciente y la política”, sino para decir de nueva manera el espíritu que anima esta publicación. Decidimos entonces invitar a tres de nuestros colaboradores cuyas contribuciones siempre han abierto horizontes de elaboración novedosos. Una sola y única pregunta les formulamos a Nieves Soria Dafunchio, Clara Cecilia Mesa y Marie-Jean Sauret:
“¿Por qué escribir hoy Desde el Jardín de Freud?”.
Esta sección reúne las repuestas que cada uno presentó en aquella ocasión.

Para ver la jornada completa siga el enlace: https://youtu.be/Amu6Tk-RY-Q
Postharvest behavior and chilling injury in avocado (Persea americana Mill) fruit cv. Hass treated with 1-methylcyclopropene, ethylene, and intermittent warming
Authors: Pachón Yerlendy Vanessa , Balaguera Lopez Helber Enrique , Florez-Velasco Nixon 
Published: May 2022

Persea americana, cv. Hass has become an important crop in Colombia due to increased exports to European markets; however, the avocado is a climacteric fruit sensitive to chilling injury, reducing its shelf-life and affecting commercialization abroad. This research aimed to evaluate the effect of 1-methylcyclopropene, ethylene, and intermittent warming on chilling injury and postharvest behavior of avocado cv. Hass. Five treatments were evaluated: Control; Intermittent warming cycles of 4 days at 2 °C + 1 day at 18 °C; Intermittent warming cycles of 7 days at 2 °C + 1 day at 18 °C; 1-methylcyclopropene, and ethylene. The fruits were stored for 29 days at 2 °C and then up to 14 days in the shelf-life period. The intermittent warming treatment 4-days cycles reduced chilling injuries. However, this treatment increased weight loss, respiration, epidermal color index, and electrolyte leakage during the storage period at 2 °C. Intermittent warming showed that Hass avocado fruit ripens faster, regardless of the application of ethylene in the shelf-life period. The results indicated that intermittent warming reduced the chilling injury, the treatment with 1-methylcyclopropene delayed ripening but it is not recommended for avocado cv. Hass when stored at 2 °C because the chilling injury is not reduced.
<em>La cultura en Cuba y en el mundo</em>: americanidad y cubanidad en Alejo Carpentier
Authors: Martínez Rodríguez Dianelkys 
Published: May 2022

La cultura en Cuba y en el mundo (2003) es un libro que reúne conferencias de Alejo Carpentier, dictadas entre 1964 y 1966. El artículo tiene el propósito de detectar los significados de la “americanidad” y “cubanidad” a partir de dicha obra, además de exponer los hallazgos de una lectura crítica que permitió identificar su sentido biográfico, visualización de relaciones sociológicas y su vinculación con la política cultural de la Revolución cubana. El discurso de Carpentier se organizó a partir de la lógica entre narrativa-música y lo universal, particular y singular, donde existen características afines tales como: la teoría de los contextos, la épica, lo real, lo maravilloso, el barroco, el tiempo, el uso de vocablos y lo folklórico. Asimismo, se reconoce el surgimiento de un creador-antropólogo, que da lugar a una conciencia nacional y política de la intelectualidad. En general, se concluye que la “americanidad” y la “cubanidad” expresan una identidad nacional surgida de la Conquista y colonización.