bluuebunny/crossref_metadata_2025_split huggingface dataset:
Representations and imaginaries of cities in the opening sequences of three U.S. TV series: The Sopranos, Weeds and House of Cards
Authors: Gallardo Marta , García-Reyes David 
Published: December 2022

Representaciones e imaginarios urbanos a través de los opening de tres series estadounidenses: The Sopranos, Weeds y House of Cards
Las secuencias de apertura de una serie o de una película funcionan como preámbulo en el que se encapsulan elementos denotativos de la trama o se insertan atributos estéticos e iconográficos directamente relacionados con la historia. Este trabajo analiza la representación de la ciudad contemporánea estadounidense a través de los openings de tres series recientes con notable recepción: The Sopranos (HBO, 1999–2007), Weeds (Showtime, 2005–2012) y House of Cards (Netflix, 2013–2018). Se lleva a cabo una caracterización de estos espacios urbanos, la representación y uso que se hace de sus elementos, la diferenciación (o no) entre “realidad” y ficción en cuanto a la configuración de su dimensión espacial y urbana, junto con la proyección mediática de los distintos contextos urbanos. The Sopranos y House of Cards dan cuenta de la figuración y funcionalidad de núcleos urbanos conocidos globalmente (Nueva York y Washington DC) y de su espacio metropolitano. Weeds, pero también The Sopranos, detalla lugares del ámbito suburbano, ejemplo del urban sprawl estadounidense e ideal residencial familiar, en contraposición con la ciudad vinculada a la cultura y la historia de House of Cards. Las tres secuencias de apertura conforman y representan los estereotipos del imaginario colectivo que tenemos del paisaje urbano de la costa este y oeste del país.
Pengaruh Kemandirian Belajar Terhadap Minat Belajar IPA Siswa Kelas VIII SMP
Authors: Linasari Reni , Arif Syaiful 
Published: December 2022

Pada dasarnya pendidikan IPA penting untuk diajarkan pada setiap jenjangnya. Pada jenjang SMP pendidikan IPA merupakan sebuah pembelajaran yang diajarkan secara terpadu secara utuh dan tidak dapat dipisahkan. Karena begitu kompleknya pembelajaran IPA maka diperlukan sebuah mental dan minat belajar yang tinggi dalam diri peserta didik. Minat belajar haruslah ditumbuhkan pada diri peserta didik. Karena kompleksnya pendidikan IPA, diketahui semangat dan minat belajar peserta didik kelas VIII di SMPN 1 Sambit terhadap mata pelajaran IPA mulai menurun. Menurunnya minat belajar dapat dipengaruhi oleh rendahnya kemandirian belajar peserta didik. Oleh karena itu peneliti tertarik untuk meneliti lebih dalam tentang pengaruh kemandirian belajar terhadap minat belajar IPA di SMPN 1 Sambit. Artikel ini bertujuan untuk mengetahui pengaruh kemandirian belajar peserta didik terhadap minat belajar IPA kelas VIII di SMPN 1 Sambit. Pendektan yang digunakan dalam penelitian ini adalah pendekatan kuantitatif, dengan jenis penelitian ex post facto. Teknik pengambilan data dilakukan secara random sampling. Jumlah sampel 56 peserta didik.Teknik analisis data dilakukan dengan cara deskriptif statistik Hasil penelitian yang dilaksanakan menunjukkan persamaan persamaan regresi dengan Y= 18.641+ 0,352. Artinya setiap peningkatan satu unit variabel kemandirian belajar akan menyebabkan peningkatan pada variabel minat belajar sebesar 0,352 unit. Besarnya kontribusi kemandirian belajar terhadap minat belajar peserta didik ditunjukkan dengan koefesien determinasi sebesar 0,125. Hal ini berarti bahwa penaikan atau penurunan minat belajar dipengaruhi oleh kemandirian belajar sebesar 12,5%, sedangkan 87,5% dipengaruhi oleh faktor lainnya yang tidak diteliti dalam penelitian ini.
An Improved Equilibrium Optimizer for Optimal Placement of Distributed Generators in Distribution Systems Considering Harmonic Distortion Limits
Authors: Pham Thai Dinh , Nguyen Thang Trung , Le Chi Kien 
Published: December 2022

Abstract
This paper proposes an improved equilibrium optimizer (IEO) for determining optimal location and effective size of distributed generation units (DGUs) in the distribution systems in order to minimize the total power loss on distribution branches, investment cost, and operation and maintenance cost. To reach good solutions of DGUs placement, limits regarding voltage, current and harmonic flows are also seriously concerned and they must be satisfied exactly within a predetermined range. Especially, individual harmonic distortion (IHD) and total harmonic distortion (THD) of bus voltage must falls into IEEE Std. 519. The proposed IEO is developed from the original equilibrium optimizer (EO), which was motivated by control volume mass balance models. This novel algorithm can effectively expand the search area and avoid the premature convergence to low quality solution spaces. With the determined solutions from IEO, not only are the voltages well improved, but also the harmonics are mitigated from the offending values down to the allowable values of IEEE Std. 519. Moreover, the total power loss is significantly reduced from 0.2110 MW to 0.0815 MW, 0.2245 MW to 0.07197 MW and 0.3161 MW to 0.1515 MW for IEEE 33-bus, IEEE 69-bus and IEEE 85-bus radial distribution systems, respectively. Not only that, the total cost of DGUs is also more economical and consumes only $3.4753 million, $3.2840 million and $3.0593 million corresponding to the three systems for a 20-year planning period. The performance of the proposed algorithm is compared to three other implemented methods consisting of artificial bee colony (ABC) algorithm, salp swarm algorithm (SSA) and EO, and eight previously published methods for the three test systems. The comparisons of results imply that IEO is better than other methods in terms of performance, stability and convergence characteristic.
Beyond the acute-phase response: systemic Serum Amyloid A 1/2 promotes inflammasome activation, apoptosis, and necrosis in breast cancer
Authors: Olivier Daniel Wilhelm , Fourie Carla , du Plessis Manisha , de Jager Louis Johann , Engelbrecht Lize , McGregor Nathaniel Wade , Shridas Preetha , de Beer Frederick C , de Villiers Willem Johan Simon , Pretorius Etheresia , Engelbrecht Anna-Mart 
Published: December 2022

Abstract
Background
Past research has identified the family of Serum Amyloid A (SAA) proteins to be intricately involved in inflammatory signaling and various disease pathologies. In cancer patients, SAA proteins have been reported to be upregulated in blood and tumor tissue, correlating in many instances with disease progression. However, the exact role of SAA proteins in cancer pathology remains to be fully elucidated. We, therefore, investigated systemic SAA1 and SAA2 (SAA1/2) in modulating the inflammasome, cell cycle, apoptosis, and epithelial-to-mesenchymal transition (EMT).
Methods
Breast cancer allografts were established in wild-type mice (WT), and mice lacking the SAA1/2 orthologs (SAADKO). Subsequently, tumor volume was monitored, species survival determined, the inflammatory profiles of mice assessed with a multiplex assay, and tumor molecular biology and histology characterized with western blotting and H&E histological staining.
Results
WT tumor-bearing mice had increased levels of plasma SAA compared to WT control mice, while SAADKO control and tumor-bearing mice presented with lower levels of SAA in their plasma. SAADKO tumor-bearing mice also displayed significantly lower concentrations of the systemic inflammatory markers, IL-1β, IL-6, and IL-10 compared to WT tumor-bearing mice. Tumors from SAADKO mice overall had lower levels of SAA compared to tumors from WT mice, decreased apoptotic (cytochrome c, caspases 9/3, PARP), and inflammasome (NFκB, caspase 1, NLRP3) signaling, with little to no tumor necrosis.
Conclusions
We show that systemic SAA1/2 promotes the activation of the NLRP3 inflammasome in breast cancer tumors and the generation of pro-inflammatory cytokines, which promotes apoptosis and tumor necrosis. Based on these findings, we hypothesize that SAA1/2-mediated necrosis is due to NLRP3-mediated pore formation in membranes, while apoptosis signaling is likely mediated via the TIF-IA-NF-κB-apoptosis axis.
Analysis of Convergence in Energy Intensity of GDP in ASEAN-5 Countries: A Fractional Integration Approach with Fourier Function after Wavelet Transform
Authors: TATAR Havanur ERGÜN , KONAT Gökhan 
Published: December 2022

Abstract
It is seen that the convergence phenomenon, which emphasizes equality in the income levels of the countries, has recently intensified in energy studies. In this study, the convergence of the GDP in energy intensity was examined with the data for the period 1980–2019. The wavelet transform method was used by following a different path from the existing literature. In this way, the convergence phenomenon has been examined in different time periods as short-term, medium-term, and long-term. At this point, the study is an original study that tests the energy density convergence of GDP for ASEAN-5 in different time periods. The results reveal that countries show different convergence trends in the medium and long term. Since the convergence hypothesis is valid only in the short term, it is important that countries implement different policies for different time periods in the medium and long term, since short-term policies will be valid.
Inferential Survey on oncology information systems using predictive analytics
Authors: Naik Kirtida , Garg Bindu 
Published: December 2022

Abstract
Cancer is one of the deadliest diseases diagnosed among the population across the globe. The number of cases is increasing each year so are the different diagnosis tools and techniques and technologies. Significant increase in the mortality rate worldwide leads to tremendous scope to device and implement latest computer aided diagnostic systems for early detection. One such technique is machine learning coupled with medical imaging modalities that have proved to be efficient in diagnosing various medical conditions. Current study presents a review of different machine learning techniques applied on emerging modalities for cancer diagnosis from 2018 to 2022. It was found that traditional machine learning algorithms like SVM, GMM performed very well in classification. But overall deep learning has dominated the field of medical image analysis. Researchers have achieved 100% accuracy in classification of cancerous and normal tissue images using medical image analysis with the help of machine learning. This survey presents the studies based on Lymphoma cancer analysis based on HIS systems
Modelling the impact of sodium intake on cardiovascular disease mortality in Mexico
Authors: Vargas-Meza Jorge , NILSON EDUARDO AUGUSTO , Nieto Claudia , Khandpur Neha , Denova-Gutiérrez Edgar , Valero-Morales Isabel , Barquera Simón , Campos-Nonato Ismael 
Published: December 2022

Abstract
Background
Cardiovascular diseases (CVD) represent the main cause of death in Mexico, while high blood pressure is suffered by about half of the adult population. Sodium intake is one of the main risk factors for these diseases. The Mexican adult population consumes about 3.1 g/day, an amount that exceeds what is recommended by the World Health Organization (WHO) < 2g sodium/day. The objective of this study was to estimate the impact of reducing sodium intake on CVD mortality in Mexico using a scenario simulation model.
Methods
The Integrated Model of Preventable Risk (PRIME) was used to estimate the number of deaths prevented or postponed (DPD) due to CVD in the Mexican adult population following the following sodium intake reduction scenarios: a) according to the WHO recommendations; b) an “optimistic” reduction of 30%; and c) an "intermediate" reduction of 10%.
Results
The results show that a total of 27,700 CVD deaths could be prevented or postponed for scenario A, 13,900 deaths for scenario B, and 5,800 for scenario C. For all scenarios, the highest percentages of DPP by type of CVD are related to ischemic heart disease, hypertensive disease and stroke.
Conclusions
The results show that if Mexico considers implementing policies with greater impact to reduce sodium/salt consumption, a significant number of deaths from CVD could be prevented or postponed.
Preservation of beam quality in a plasma-wakefield accelerator
Authors: Lindstrøm Carl Andreas , Beinortaitė Judita , Svensson Jonas Björklund , Boulton Lewis , Chappell James , Diederichs Severin , Foster Brian , Garland Matthew , Gonzalez Pau , Loisch Gregor , Peña Felipe , Schröder Sarah , Thévenet Maxence , Wesch Stephan , Wing Matthew , Wood Jonathan , D'Arcy Richard , Osterhoff Jens 
Published: December 2022

Abstract
Radio-frequency accelerators are engines of discovery, powering high-energy physics and photon science, but are also large and expensive due to their limited accelerating fields. Plasma-wakefield accelerators (PWFAs) provide orders-of-magnitude stronger fields in the charge-density wave behind a particle bunch travelling in a plasma, promising particle accelerators of greatly reduced size and cost. However, PWFAs easily degrade the beam quality of the bunches they accelerate. Emittance, which determines how tightly beams can be focused, is a critical beam quality in for instance colliders and free-electron lasers, but is particularly prone to degradation. We demonstrate, for the first time, emittance preservation in a high-gradient and high-efficiency PWFA while simultaneously preserving charge and energy spread. This establishes that PWFAs can accelerate without degradation—essential for energy boosters in photon science and multistage facilities for compact high-energy particle colliders.
Thermally Stable, Semi-transparent Superhydrophobic Nanocomposites with Excellent Mechanical Strengths
Authors: Lim Ho Sun , Park Yeon Hee , Kim Hyo Jin , Shin Gyo Jic , Choi Kyung Ho , Yang Hoichang 
Published: December 2022

Abstract
With the development of smart electronic devices, the importance of surface-protective coatings is rapidly increasing. Superhydrophobic nanocomposite materials are promising protective coatings that exhibit potential for anti-wetting, self-cleaning, and antibacterial applications. However, their poor mechanical durability makes their practical application difficult. Additionally, rough surface geometries induce incident light scattering, thereby reducing the transparency and limiting their optical applications. This study describes semi-transparent superhydrophobic nanocomposites coatings with improved mechanical strength and thermal stability obtained through simple spray coating. We mixed reactive polydimethylsiloxane (PDMS) as a binder with low surface free energy and high thermal resistance with fluorinated silica nanoparticles. PDMS polymers were functionalized to improve their hydrophobicity and adhesion properties through hydrosilylation with acrylate monomers. As a result, our superhydrophobic coatings had a high-water repellency of above 160° and transparency of approximately 60% at a wavelength of 550 nm. The coated surfaces exhibited an outstanding pencil hardness of 5H and sufficient clarity to identify objects through them. After heat treatment at 400°C, the hardness increased to 6H while maintaining superhydrophobicity. Additionally, various contaminants were easily removed with water spraying. Our semi-transparent superhydrophobic nanocomposite materials can be widely applied in hard coatings for mobile displays, solar cell panels, self-cleaning paint, and outdoor facilities.
Evaluation of the gut microbiota patterns in patients with COVID-19: a protocol for a pilot study
Authors: Nejadghaderi Seyed Aria , Nazemalhosseini-Mojarad Ehsan , Fazlollahi Asra , Pirsadeghi Ali , Khalili Ainaz , Rezaei Nima 
Published: December 2022

Abstract
Background
SARS-CoV-2 caused an outbreak in late December 2019. It has been suggested that the gut microbiota dysbiosis influences severity, mortality, and quality of life of patients with COVID-19. So, identifying the gut microbiota pattern could be helpful to determine prognosis of the disease, and maybe determine some potential treatment approaches. Our aim will be to compare gut microbiota patterns between patients with severe or non-severe COVID-19, and healthy controls.
Methods
We will include 40 samples: 20 samples from COVID-19 patients, including 10 severe patients and 10 non-severe patients, and 20 samples from healthy controls. Total bacterial DNA will be extracted from samples and 16S rRNA gene will be amplified through two PCR stages. Fecal samples will be analyzed using a targeted metabolomics technique, and a total of 198 compounds will be measured. The differences in each RNA or DNA expression between patients with severe COVID-19, patients with non-severe COVID-19, and controls will be compared. Also, we will assess the relationships between each DNA or RNA as well as the risk of COVID-19 severity, sort of clinical manifestations, and comorbidities
Discussion
The results of our study could be the backbone for further trials which might lead to development of prognostic factors and treatment options.
Orthostatic Proteinuria without Left Renal Vein Entrapment in an Old Obese Female：A Case Report and Literature Review
Authors: Lin Liling , Zhang Kai , Yang Xiao , Lin Lu , Li Xuemei , Qiu Ling 
Published: December 2022

Abstract
Background
Left renal vein (LRV) entrapment, namely nutcracker syndrome (NCS), is one of the most common causes of orthostatic proteinuria. In stereotype, orthostatic proteinuria is often accompanied by left renal vein obstruction and found in young and underweight individuals. Here, we report a rare case with orthostatic proteinuria in an old obese female caused by a type of rare congenital inferior vena cava (IVC) interruption.
Case presentation
This paper reported a 65-year-old obese woman, who suffered from fluctuated proteinuria, had been misdiagnosed as chronic glomerulitis for 30 years. Instead of having any sign of NCS, she had a unique type of IVC interruption. Most venous blood from infrarenal IVC and right kidney drained into her LRV, and then through the expanded communicating vessel, drained into the left ascending lumbar vein which extended as hemizygous vein. To the best of our knowledge, this is the first case of orthostatic proteinuria attributed to the subsequent hemodynamic irregularity caused by IVC interruption without LRV entrapment.
Conclusion
Adult-onset orthostatic proteinuria is relatively rare, hard to be recognized and could be misdiagnosed as chronic glomerulonephritis. The case provided a novel differential diagnostic condition for those who suffered from fluctuated proteinuria of unknown causes.
Influence of Microstructure on Tribological Behaviors of Al6061 Metal Matrix composite reinforced with Silicon Nitride (Si 3 N 4 ) and Silicon Carbide (SiC) micro particles
Authors: Arya Ranjeet Kumar , Kumar Rajan , Telang Amit 
Published: December 2022

Abstract
Dual step stir casting method was utilized to develop Al6061 composite reinforced with SiC (micron) and Si3N4 (submicron) particles in varying proportion and weight percentage. A homogeneous and uniform distribution of hybrid reinforcement without significant porosity was observed in the microstructure of the composites. X-ray diffraction (XRD) results manifest that Si3N4 and SiC particles are thermodynamically stable during the processing and no unwanted phases were detected. Elemental mapping was also performed for phase identification. With reference to the base alloy significant improvement was noticed in physical and tribological properties of hybrid composites. Maximum rise in hardness was 54.64%. Abrasive wear test results from pin on disc reveals that wear resistance get enhanced for all composition and load is found to be most dominating factor affecting wear behavior.
RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium
Authors: Hu Ting , Liu Lan , Wang He , Yang Mei , Xu Bocheng , Lin Ziyuan , Jing Xiaolei , Wang Ping , Liu Yanyan , Sun Huaqin , Liu Shanling 
Published: December 2022

Abstract
Noncompaction of the ventricular myocaridium (NVM), as the third most commonly diagnosed cardiomyopathy, is characterized with highly variable clinical manifestations. Due to high heterogeneity, the genetic etiology of 40–60% NVM cases remains unknown. Here, we reported two infants of NVM in a non-consanguineous family with typically clinical presentation of persistent bradycardia since prenatal period. A homozygous missense mutation (R223L) of RCAN family member 3 (RCAN3) was detected in both infants by whole-exome sequencing. In the zebrafish model with rcan3 deficiency (MO-rcan3ATG-injected embryos), a marked lower heart rate without significant cardiac looping defects was detected in MO-rcan3ATG-injected embryos, which was similar to the NVM patients. Developmental dysplasia of both endocardial and myocardial layers were detected in zebrafish embryos with rcan3 deficiency. RCAN3 R223L variant mRNAs were unable to rescue heart defects caused by rcan3 knockdown. In rcan3-knockdown zebrafish model, several genes involved in cardiomyopathies were shown to be significantly regulated through multiple signaling pathways. This is the first report of RCAN3-related NVM in human. We suggest that RCAN3 as a novel susceptibility gene of cardiomyopathies, especially in NVM, while R223L variant was a potential loss-of-function variant.
High quality long-read genomes produced from single MinION flow cells clarify polyploid and demographic histories of critically endangered ash species (Fraxinus: Oleaceae)
Authors: Fleck Steven , Tomlin Crystal , Coelho Flavio da Silva , Richter Michaela , Danielsen Erik , Backenstose Nathan , Krabbenhoft Trevor , Lindqvist Charlotte , Albert Victor 
Published: December 2022

Abstract
With populations of threatened and endangered plants and animals declining worldwide, it is important that high quality genomic records of these species are preserved before they are lost forever. Here, we demonstrate that data from single Oxford Nanopore Technologies (ONT) MinION flow cells can, even in the absence of highly accurate short DNA-read polishing, produce high quality de novoplant genome assemblies that are adequate for downstream analyses, such as synteny and ploidy evaluations, paleodemographic analyses, and phylogenomics. This study focuses on three North American ash tree species in the genus Fraxinus(Oleaceae) that were recently added to the International Union for Conservation of Nature (IUCN) Red List: Fraxinus americana (white ash), F. nigra (black ash), and F. pennsylvanica (green ash). These three species have become critically endangered primarily due to destructive herbivory by the invasive Emerald Ash Borer (EAB, Agrilus planipennis), a buprestid beetle pest recently introduced to North America from East Asia. Our draft genomes, which range from 776.3-851.9 megabases, have similar sequence accuracy as a recently published chromosome-level F. pennsylvanica assembly, with annotations that outperform that genome in terms of the number of complete Benchmarking Universal Single-Copy Orthologs (BUSCOs) identified. Our results support a whole genome triplication at the base of the Oleaceae as well as a subsequent whole genome duplication shared by Syringa, Osmanthus, Olea, and Fraxinus. Additionally, our results from ONT long reads alone suggest that our F. nigra accession is more inbred compared with the F. americana and F. pennsylvanica individuals sequenced. In summary, our powerful downstream analyses enabled by single MinION flow cell genome assemblies suggest that Oxford Nanopore technology can provide a relatively fast and inexpensive approach to sequence the 5,232 critically endangered plant species currently on the IUCN Red-List.