bluuebunny/crossref_metadata_2025_split huggingface dataset:
The coupling coordination development between green finance and environmental governance in China: Measurement and spatial-temporal analysis
Authors: Peng Geng , Wang Tiantian , Ruan Lijuan , Tian Kaiyou 
Published: November 2022

Abstract
To direct financial resources for achieving the goal of environmental governance, the Chinese government has devoted increasing efforts to developing green finance. However, few studies explored the relationship between green finance and environmental governance. Thus, this paper first theoretically discusses the interactive connection between green finance and environmental governance. Then we construct two comprehensive indicator systems and use entropy method to calculate green finance index (GFI) and environmental governance index (EGI) for 30 provinces of China from 2004 to 2020. Using the data of GFI and EGI, the coupling coordination degree of green finance and environmental governance (CCDGE) is measured by coupling coordination model. The findings of spatial-temporal analysis show that GFI has grown more rapidly than EGI, but the development of green finance still lags behind environmental governance because of its short history. Although CCDGE is increasing steadily, it has been hovering in the moderate coupling coordination stage for a long time, and still has a great distance to the high coupling coordination level. The relationship between green finance and environmental governance are still in a state of disorderly development that restricts each other. Additionally, there are obvious regional differences in GFI and EGI and the interactive effect between green finance and environmental governance. Specifically, GFI and EGI in eastern China are highest, while CCDGE presents with a ladder decline status of ‘eastern region > central region > northeast region > west region’.
Optimal Time Interval Between Neoadjuvant Platinum-based Chemotherapy and Interval Debulking Surgery in High-grade Serous Ovarian Cancer
Authors: Andrikopoulou Angeliki , Liontos Michalis , Apostolidou Kleoniki , Theofanakis Charalampos , Markellos Christos , Fiste Oraianthi , Kaparelou Maria , Koutsoukos Konstantinos , Thomakos Nikolaos , Haidopoulos Dimitrios , Rodolakis Alexandros , Dimopoulos Meletios-Athanasios , Zagouri Flora 
Published: November 2022

Abstract
BACKGROUND
There is limited data on the optimal time interval between the last dose of neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS) in high-grade serous ovarian carcinoma (HGSC).
METHODS
We retrospectively identified patients with stage IIIC/IV HGSC who received NACT followed by IDS during a 15-year period (January 2003-December 2018) in our Institution that is certified by the European Society of Gynecologic Oncology (ESGO) as a center of excellence for the treatment of ovarian cancer.
RESULTS
Overall, 115 patients with HGSC stage IIIC/IV were included. Median age of diagnosis was 62.7 years (IQR: 14.0). 76.5% (88/115) of patients were diagnosed with IIIC HGSC and 23.5% (27/115) with IV HGSC. Median PFS was 15.7 months (95% CI: 13.0–18.5) and median OS was 44.7 (95% CI: 38.8–50.5). Patients were categorized in groups according to time interval from NACT to IDS (< 4 weeks (group A); 4–5 weeks (group B); 5–6 weeks (group C); >6 weeks (group D). Patients with a time interval IDS to NACT ≥ 4 weeks had significantly shorter PFS (p = 0.004) and OS (p = 0.002). Median PFS was 26.6 months (95% CI: 24–29.2) for patients undergoing IDS < 4 weeks after NACT versus 14.4 months (95% CI: 12.6–16.2) for those undergoing IDS later (p = 0.004). Accordingly, median OS was 66.3 months (95% CI: 39.1–93.4) versus 39.4 months (95% CI: 31.8–47.0) in the < 4 week versus > 4 week time interval NACT to IDS groups (p = 0.002). On multivariate analysis, short time interval (< 4 weeks) from NACT to IDS was an independent factor of PFS (p = 0.004) and OS (p = 0.003).
CONCLUSION
We have demonstrated that performing IDS within 4 weeks after NACT may be associated with better survival outcomes. Multidisciplinary coordination of ovarian cancer patients is required to avoid any unnecessary delays.
A continuum structural topology optimization method considering frequency constraints and the effect of self-weight
Authors: Rong Jianhua , Song Yingjie , Rong Xuanpei , Zhao Lei , Yi Jijun , Zhou Quan 
Published: November 2022

Abstract
This work proposes a method for optimizing the continuum structural topology under multiple load cases considering frequency constraints and the effect of self-weight. An improved Solid Isotropic Material with Penalization (SIMP) model is proposed to avoid the parasitic effect. At the same time, new matching smooth penalty functions on the element stiffness, volume and mass are constructed to greatly reduce the number of low-order pseudo-modes in the optimized structure. And low-order pseudo-mode identification and deletion measures are introduced to solve the pseudo-mode problem. The Heaviside three-field mapping scheme and two varied volume constraints are introduced to obtain a clear 0/1 distribution. Moreover, a volume change rate constraint measure of low-physical density elements is proposed to greatly improve optimization computation efficiency for the structural topology problem considering both frequency constraints and the effect of self-weight. It is concluded from examples that the proposed method is effective and robust for generating an optimal topology.
The Role of Anti-Mullerian Hormone and Other Correlates in Patients with Polycystic Ovary Syndrome
Authors: Moursi Moaz O. , Ibrahim Ayman R. , Salem Haya , Marzouk Sandy , Al-Meraghi Sara , Al-Ajmi Maha , Al-Naimi Alreem , Khan Mohammad , Alansari Lolwa 
Published: November 2022

Abstract
Background
Anti-Müllerian hormone (AMH) has recently emerged as a promising biomarker for the detection of polycystic ovarian morphology. In polycystic ovary syndrome (PCOS), an elevated level of AMH has been suggested to add value to the Rotterdam criteria in cases of diagnostic uncertainty. In this study we evaluated the correlation between AMH and PCOS, and the potential role of AMH in PCOS diagnosis.
Methods
A case-control study was performed on a total of 200 females, 100 of which were diagnosed with PCOS as per Rotterdam revised criteria (2003) and 100 as the control (non-PCOS group). Patient medical records were therefore retrieved for clinical, biochemical and ultrasound markers for PCOS diagnosis. Sensitivity, specificity, area under receiver operating characteristic (AUROC) curve, and multivariate linear regression models were applied to analyze our data.
Results
Mean serum levels of LH and AMH, and LH/FSH ratio were significantly different between compared groups. In the PCOS group, the mean serum AMH level was 6.78 ng/mL and LH/FSH ratio was 1.53 while those of controls were 2.73 ng/mL and 0.53, respectively (p < 0.001). The most suitable compromise between 81% specificity and 79% sensitivity was obtained with a cut-off value of 3.75 ng/mL (26.78 pmol/L) serum AMH concentration for PCOS prediction, with an AUROC curve of 0.9691.
Conclusion
Serum AMH cut-off level of 3.75 ng/mL was identified as a convenient gauge for the prediction of PCOS and an adjuvant to the Rotterdam criteria.
Prognostic value of KRAS exon 2, exon 3 and exon 4 mutations in colorectal cancer patients
Authors: Asako Kentaro , Hayama Tamuro , Hashiguchi Yojiro , Miyata Toshiya , Fukushima Yoshihisa , Shimada Ryu , Kaneko Kensuke , Nozawa Keijiro , Matsuda Keiji , Fukagawa Takeo 
Published: November 2022

Abstract
The clinical significance of many RAS-family mutations in colorectal cancer (CRC) remains unclear. The purpose of this study was to investigate the relationship of mutations on an exon basis (i.e., mutations in KRAS exons 2, 3 and 4 and in NRAS) with clinicopathological features and prognosis in CRC. We performed a retrospective cohort study of the medical records and frozen tissue samples of 268 consecutive patients with stage I-III CRC who underwent curative resection at a single institution in 2014–2018. The RAS mutation rate was significantly associated with age and histology. Patients with KRAS exon 2 mutations exhibited shorter RFS compared to those with KRAS wild-type, KRAS exon 3 mutations, KRAS exon 4 mutations and NRAS mutations (73.0% vs. 85.5%, 86.7%, 85.7%. p = 0.031). Age and histology were independent risk factors for RAS mutations. RAS mutations were independent prognostic factors with respect to RFS in patients with stage I–III CRC. In stage I–III CRC patients, KRAS exon 2 mutations have the worst prognosis, while RAS wild type, RAS exon 3 mutations, RAS exon 4 mutations and NRAS mutations have better prognoses.
Application and characterization of a novel PVDF-HFP/PVP polymer composite with MoO3 nanowires as a protective coating for wood
Authors: Žigon Jure , Centa Urška Gradišar , Remškar Maja , Humar Miha 
Published: November 2022

Abstract
The coatings on wood must sometimes give aesthetic and basic protection to wooden elements and prevent the development and transmission of microorganisms. Several polymers containing different nanoparticles have already been offered to day for this purpose. A present research presents a novel poly(vinylidene fluoride-co-hexafluoropropylene (PVDF-HFP)/polyvinylpyrrolidone (PVP) polymer composite with MoO3 nanowires with the ability to form coating films on wood. The films of the developed coating exhibit elastic behaviour, which depends on the coating film thickness (tested wet film thicknesses 90 µm, 180 µm and 360 µm). The developed coating showed the ability to interact well with the surface of common beech (Fagus sylvatica L.), in terms of wetting (contact angles of 15.6°), fast spilling on the surface, good penetration of the coating in wood structure, formation of up to 40 µm-thick films with excellent pull-off adhesion strength (6 MPa). An increased roughness of wood coated with C + MoO3 was a consequence of wood etching by the dimethylformamide solvent present in the coating. Moreover, the presence of C + MoO3 on wood made it considerably more hydrophobic, with contact angle of water droplets raising to 123° from initially 46° measured on uncoated wood. The irradiation of wood surfaces with ultra-violet light resulted in colour changes on both uncoated and coated wood, visible to the naked eye. The wood samples coated with C + MoO3 has a good resistance to water, alcohol and dry heat (grade 3 to 4). The antimicrobial testing showed that the presence of MoO3 in the developed coating plays an important role in the resistance of the coated wood blue-stain fungi and mould development. The developed PVDF-HFP/PVP/MoO3 coating has an excellent ability to interact with the wood surface and has the potential to be used as a protective coating for wood in sensitive environments.
National survey on clinical and genetic characteristics of patients with hereditary angioedema in Latvia
Authors: Kanepa Adine , Nartisa Inga , Rots Dmitrijs , Gailite Linda , Farkas Henriette , Kurjane Natalja 
Published: November 2022

Abstract
Background
Hereditary angioedema (HAE) is a rare and life-threatening inborn error of immunity. HAE is mostly caused by pathogenic variations in the serine protease inhibitor gene 1 (SERPING1), leading to deficient or dysfunctional C1-inhibitor (C1-INH), overproduction of bradykinin, and development of recurrent subcutaneous and/or submucosal oedema. We aimed to describe the clinical features and genetic spectrum of hereditary angioedema with C1-INH deficiency (C1-INH-HAE) in Latvia.
Methods
All patients from Latvia diagnosed with HAE (types I/II) from 2006 to March 2022 were included in the study. Laboratory tests and clinical data were analysed, and genetic tests with Sanger sequencing and whole genome sequencing were performed.
Results
The study identified 10 C1-INH-HAE patients (nine females, one male) from eight families. Of all patients, seven (70%) had HAE type I and three (30%) had HAE type II. The median age of patients was 54 years and the median age at onset of symptoms was 15 years. A significant delay (20.5 years) until diagnosis was observed, and 60% of patients had a positive family history of angioedema. All HAE patients have been hospitalised a median two times during their lifetime. Skin (100%), abdominal (80%), and airway (80%) oedema were the most frequent symptoms. Triggering factors (60%) and prodromal symptoms (90%) were referred. Attacks were severe in 50% of patients, moderate in 10%, and mild in 40%. Pathogenic variations of SERPING1 were identified in eight patients (six families), confirming the diagnosis molecularly. In two patients (two families), no pathogenic variations in the genes were found even after whole genome sequencing.
Conclusions
Current data shows a significant delay and clear underdiagnosis of HAE in Latvia. Higher awareness and better information and communication between doctors would improve the diagnosis and management of HAE; as would screening of family members, patients with recurrent angioedema unresponsive to antihistamines and glucocorticoids, and patients with recurrent episodes of severe, unexplained abdominal pain.
Cost-effectiveness of intraoperative radiation therapy versus intensity-modulated radiation therapy for the treatment of early breast cancer: A disinvestment analysis
Authors: Muñoz-Montecinos Carlos , González-Browne Catalina , Maza Felipe , Carreño-Leiton Diego , González Pablo , Chahuan Badir , Quirland Camila 
Published: November 2022

Abstract
Background
Adjuvant radiotherapy represents a key component in curative-intent treatment for early-stage breast cancer patients. In last years, two accelerated partial breast irradiation (APBI) techniques are preferred for this population in our organization: electron-based Intraoperative radiation therapy (IORT) and Linac based External Beam Radiotherapy, particularly Intensity-modulated radiation therapy (IMRT-APBI). Recently published long-term follow-up data evaluating these technologies have motivated a health technology reassessment of IORT compared to IMRT.
Methods
We developed a Markov model to simulate health-state transitions from a cohort of women with early-stage breast cancer, after lumpectomy and adjuvant APBI using either IORT or IMRT techniques. The cost-effectiveness from a private health provider perspective was assessed from a disinvestment point of view, using life-years (LYs) and recurrence-free life-years (RFLYs) as measure of benefits, along with their respective quality adjustments. Expected costs and benefits, and the incremental cost-effectiveness ratio (ICER) were reported. Finally, a scenario analysis was performed to evaluate the cost-effectiveness if equipment maintenance costs are removed.
Results
IORT technology was dominated by IMRT in all cases (i.e., less benefits with greater costs), except when benefits were estimated as LYs, where no differences were found and therefore the ICER was undefined. Despite small differences were found regarding benefits, costs were considerably higher for IORT. In the scenario analysis without equipment maintenance costs, IORT was still dominated by IMRT.
Conclusions
For this cohort of patients, IMRT was, at least, non-inferior to IORT in terms of expected benefits, with considerably lower costs. As a result, IORT disinvestment should be considered, favoring the use of IMRT in these patients.
Screening of bread wheat (Triticum aestivum L.) genotypes resistance to yellow rust along with grain yield
Authors: Olana Abera 
Published: November 2022

Abstract
Yellow rust caused by Puccinia striiformis f.sp tritici is one of the main diseases of wheat (Triticum aestivum L.) in the world, causing up to 50–100% of yield losses under favorable environmental conditions. Developing resistant cultivars is an efficient, economical, environmentally friendly and simple approach in combating wheat yellow rust. This study was carried out to evaluate spring bread wheat genotypes for their reaction to yellow rust under field conditions. Two hundred and forty spring bread wheat genotypes and seven check varieties were evaluated for their reaction to yellow rust disease under field conditions in non-replicated trials, using an augmented design. Collected data were analyzed using ANOVA. The genotypes were classified as resistant, moderately resistant, moderately susceptible and susceptible based on the percentage disease severity scored. Up to 90% disease severities were recorded from susceptible check kubsa and the other 23 genotypes. There was a significant difference of yellow rust severity, Coefficient of infections, AUDPC, yield and yield component values among genotypes, based on these parameters we identified 19 genotypes low disease severity and grain yield.
Recommendation of New Design Spectra for Iran Using Modified Newmark Method
Authors: Moghaddam Hassan , Darbani Mohammadali Sanagar , Sadrara Ali , Hajirasouliha Iman 
Published: November 2022

Abstract
The Newmark design spectra are commonly adopted in seismic codes to calculate design spectra, while these spectra generally differ from the statistically driven ones. This study aims to re-construct the Iranian design spectra by implementing a modified Newmark method on an extensive database of previous earthquakes in Iran. To this end, three sets of earthquakes recorded at three different sites are considered. The effects of parameters such as source-to-site distance, the magnitude of ground motion, and the shear wave velocity are evaluated. Subsequently, the amplification factors are obtained through a statistical approach, and the spectral bounds are calculated for three site categories and two types of earthquake magnitudes. As a result, for the first time, the coefficients of the site design spectrum of Iran are presented as a function of ground motion’s magnitude for the aforementioned site categories. The calculated coefficients can be used to modify the Newmark spectral values in displacement, velocity, and acceleration-sensitive regions to obtain suitable design spectra. Finally, a comprehensive statistical study is conducted on earthquake parameters to assess the characteristics of the earthquakes in Iran from statistical perspective. The proposed design spectra can address most shortcomings of 4th edition of the Iranian seismic design code, and it is recommended to include them in the next revision.
Characterization of nitrocellulose (NC)-ammonium dinitramide (ADN) based composite fibers prepared by electrospinning
Authors: Wang Qiong , Chang Hai , Deng Chong-qing , Yao Er-gang , Zhu Yi-ju , Pang Wei-qiang 
Published: November 2022

Abstract

The fluffy fibers based on nitrocellulose (NC)/ammonium dinitramide (ADN) with high explosives have been fabricated by electrospinning technique. The morphology, thermal stability, combustion behaviors and mechanical sensitivity of NC/ADN-based composite fibers were characterized by means of scanning electron microscope (SEM), transmission electron microscopy (TEM), differentialscanning calorimetry (DSC), gas pressure measurement of thermostatic decomposition, laser ignition and sensitivity test, respectively. The results showed that the prepared fibers with fluffy 3D macrostructure were constructed by the overlap of mirco/nanofibers with the energetic particles imbedded in NC matrix. The addition of ADN can accelerate the thermal decomposition with the peak temperature (Tp) decrease by 10.1 oC and the pressure rise time moving forward. Furthermore, ADN can decrease the ignition delay time of NC-based fibers under atmosphere at room temperature from 33 ms to 9 ms, and enhance the burning strength of NC-based fibers under normal pressure. In addition, the impact sensitivities were reduced from 100–56% for NC-based fibers containing CL-20 and from 88–56% for NC-based fibers containing RDX; the friction sensitivities were reduced from 100–64% for NC-based fibers containing CL-20 and from 84–60% for NC-based fibers containing RDX, respectively.
Simultaneous Hydrodistillation of Cedrus atlantica Manetti and Salvia rosmarinus Spenn: Optimization of anti-wood-decay fungal activity using mixture design methodology
Authors: Annemer Saoussan , zoubi Yassine Ez , Satrani Badr , Stambouli Hamide , Assouguem Amine , Bouayoun Taoufik , Farah Abdellah 
Published: November 2022

Abstract
Chemical fungicides are often harmful to people and the environment because of their toxicity. The wood protection industry places a high priority on replacing them with natural products. Therefore, this investigation focused on developing a formulation of a binary combination of Salvia rosmarinus Spenn and Cedrus atlantica Manetti obtained by Simultaneous hydrodistillation to protect the wood from decay using a mixture design methodology. The chemical composition of EOs was identified by Gas chromatography coupled with mass spectrometry (GC/MS), and their anti-wood-decay fungal activity was assessed using the macrodilution method against four fungi responsible for wood decay: Coniophora puteana, Coriolus versicolor, Gloeophyllum trabeum, and Poria placenta. The results of GC/MS identified myrtenal as a new component appearing in all binary combinations. The optimum anti-wood-decay fungal activity was observed in a combination of 60% S. rosmarinus and 40% C. atlantica essential oils, providing an effective concentration for 50 percent of maximal effect (EC50) value of 9.91 ± 1.91 and 9.28 ± 1.55 µg/mL for C. puteana and C. versicolor, respectively. The highest anti-wood-decay fungal activity for G. trabeum and P. placenta was found in the combination of 55% of S. rosmarinus and 45% of C. atlantica essential oils, with an EC50 value of 11.48 ± 3.73 and 22.619 ± 3.79 µg/mL, respectively. Combined simultaneous hydrodistillation improved the antifungal effect of these essential oils. These results could be used to improve antifungal activity and protect wood against wood-decay fungi.
Information combination and transformation (or propagation): a paradox and its resolution
Authors: Huang Hening 
Published: November 2022

Abstract
In his recent paper (https://doi.org/10.1016/j.measen.2022.100416), Willink showed two contradictory theoretical solutions to the problem of combining and transforming two sets of information about the same quantity. Each set of information is represented by a probability density function (PDF), and the transformation function is non-linear. We refer to Willink’s contradictory result as “Willink paradox”. The same potential contradiction can exist in measurement uncertainty analysis that involves combining and propagating information. The two operations: (a) information combination and (b) information transformation (or propagation) are both mathematically valid according to probability theory. Therefore, the two contradictory solutions are both theoretically correct. In practice such as measurement uncertainty analysis, however, we cannot use both solutions; we must choose one or the other. We propose an entropy metric for choosing the preferred solution, which resolves the Willink paradox. Four examples are presented to illustrate the Willink paradox and its resolution.