bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review and meta-analysis on tubal ligation and breast cancer risk
Authors: Najdi Nazila , Esmailzadeh Arezoo , Shokrpour Maryam , Nikfar Somayeh , Razavi Seyedeh Zahra , Sepidarkish Mahdi , Maroufizadeh Saman , Safiri Saeid , Almasi-Hashiani Amir 
Published: June 2022

Abstract
Background
Based on previous studies, it has been hypothesized that tube sterilization may be associated with a lower risk of breast cancer. This study aims to investigate the relationship between tubal ligation and the risk of breast cancer through a systematic review and meta-analysis.

Methods
In this systematic review and meta-analysis, PubMed/Medline, Web of Science, Scopus, and Google Scholar were searched for relevant non randomized studies published up to November 2020. Then, we screened the papers to include the eligible papers in the meta-analysis. Finally, we pooled the extracted results of individual studies to estimate the summary effect size. All analyses were done using Stata software version 13 (Stata Corp, College Station, TX).

Results
Four hundred sixty-four papers were retrieved from PubMed/Medline (160), Scopus (165), and Web of Science (139), and 21 papers from Google Scholar and manual search of references in selected full texts. After the removal of duplicates and screening of the papers, 11 articles (6 cohort and 5 case-control study) were included in the final analysis. The results of cohort (RR = 0.99, 95% CI = 0.97–1.0, I2 = 21.1%) and case control studies (OR = 0.87, 95% CI = 0.62–1.12, I2 = 88.9%) revealed that tubal ligation was not significantly associated with breast cancer risk.

Conclusion
According to our findings, tubal ligation cannot be considered as a risk factor associated with breast cancer risk.
Protocol for a scoping review of sepsis epidemiology
Authors: Wilcox M. Elizabeth , Daou Marietou , Dionne Joanna C. , Dodek Peter , Englesakis Marina , Garland Allan , Lauzon Claire , Loubani Osama , Rochwerg Bram , Shankar-Hari Manu , Thavorn Kednapa , Tricco Andrea C. 
Published: June 2022

Abstract

Introduction
Sepsis is a common, life-threatening syndrome of physiologic, pathologic, and biochemical abnormalities that are caused by infection and propagated by a dysregulated immune response. In 2017, the estimated annual incidence of sepsis around the world was 508 cases per 100,000 (95% confidence interval [CI], 422–612 cases per 100,000), however, reported incidence rates vary significantly by country. A scoping review will identify knowledge gaps by systematically investigating the incidence of sepsis.

Methods and analysis
This scoping review will be guided by the updated JBI (formerly Joanna Briggs Institute) methodology. We will search the following electronic databases: MEDLINE, EMBASE, CINAHL, and Cochrane Database of Systematic Reviews/Central Register of Controlled Trials. In addition, we will search websites of trial and study registries. We will review titles and abstracts of potentially eligible studies and then full-texts by two independent reviewers. We will include any study that is focused on the incidence of sepsis or septic shock in any population. Data will be abstracted independently using pre-piloted data extraction forms, and we will present results according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols Extension for Scoping Reviews.

Ethics and dissemination
The results of this review will be used to create a publicly available indexed and searchable electronic registry of existing sepsis research relating to incidence in neonates, children, and adults. With input from stakeholders, we will identify the implications of study findings for policy, practice, and research. Ethics approval was not required given this study reports on existing literature.
Different places, different problems: profiles of crime and disorder at residential parcels
Authors: O’Brien Daniel T. , Ristea Alina , Hangen Forrest , Tucker Riley 
Published: June 2022

AbstractCertain places generate inordinate amounts of crime and disorder. We examine how places differ in their nature of crime and disorder, with three objectives: (1) identifying a typology of profiles of crime and disorder; (2) assessing whether different forms of crime and disorder co-locate at parcels; and (3) determining whether problematic parcels explain crime and disorder across neighborhoods. The study uses 911 and 311 records to quantify physical and social disorder and violent crime at residential parcels in Boston, MA (n = 81,673). K-means cluster analyses identified the typology of problematic parcels and how those types were distributed across census block groups. Cluster analysis identified five types of problematic parcels, four specializing in one form of crime or disorder and one that combined all issues. The second cluster analysis found that the distribution of problematic parcels described the spectrum from low- to high-crime neighborhoods, plus commercial districts with many parcels with public physical disorder. Problematic parcels modestly explained levels of crime across neighborhoods. The results suggest a need for diverse intervention strategies to support different types of problematic parcels; and that neighborhood dynamics pertaining to crime are greater than problematic properties alone.
Aging gut microbiota of wild macaques are equally diverse, less stable, but progressively personalized
Authors: Sadoughi Baptiste , Schneider Dominik , Daniel Rolf , Schülke Oliver , Ostner Julia 
Published: June 2022

Abstract
Background
Pronounced heterogeneity of age trajectories has been identified as a hallmark of the gut microbiota in humans and has been explained by marked changes in lifestyle and health condition. Comparatively, age-related personalization of microbiota is understudied in natural systems limiting our comprehension of patterns observed in humans from ecological and evolutionary perspectives.

Results
Here, we tested age-related changes in the diversity, stability, and composition of the gut bacterial community using 16S rRNA gene sequencing with dense repeated sampling over three seasons in a cross-sectional age sample of adult female Assamese macaques (Macaca assamensis) living in their natural forest habitat. Gut bacterial composition exhibited a personal signature which became less stable as individuals aged. This lack of stability was not explained by differences in microbiota diversity but rather linked to an increase in the relative abundance of rare bacterial taxa. The lack of age-related changes in core taxa or convergence with age to a common state of the community hampered predicting gut bacterial composition of aged individuals. On the contrary, we found increasing personalization of the gut bacterial composition with age, indicating that composition in older individuals was increasingly divergent from the rest of the population. Reduced direct transmission of bacteria resulting from decreasing social activity may contribute to, but not be sufficient to explain, increasing personalization with age.

Conclusions
Together, our results challenge the assumption of a constant microbiota through adult life in a wild primate. Within the limits of this study, the fact that increasing personalization of the aging microbiota is not restricted to humans suggests the underlying process to be evolved instead of provoked only by modern lifestyle of and health care for the elderly.
Molecular mechanisms of Shigella effector proteins: a common pathogen among diarrheic pediatric population
Authors: Nasser Ahmad , Mosadegh Mehrdad , Azimi Taher , Shariati Aref 
Published: June 2022

AbstractDifferent gastrointestinal pathogens cause diarrhea which is a very common problem in children aged under 5 years. Among bacterial pathogens,Shigellais one of the main causes of diarrhea among children,and it accounts for approximately 11% of all deaths among children aged under 5 years. The case-fatality rates forShigellaamong the infants and children aged 1 to 4 years are 13.9% and 9.4%, respectively.Shigellauses unique effector proteins to modulate intracellular pathways.Shigellacannot invade epithelial cells on the apical site; therefore, it needs to pass epithelium through other cells rather than the epithelial cell. After passing epithelium, macrophage swallowsShigella,and the latter should prepare itself to exhibit at least two types of responses: (I) escaping phagocyte and (II) mediating invasion of and injury to the recurrent PMN. The presence of PMN and invitation to a greater degree resulted in gut membrane injuries and greater bacterial penetration. Infiltration ofShigellato the basolateral space mediates (A) cell attachment, (B) cell entry, (C) evasion of autophagy recognition, (D) vacuole formation and and vacuole rapture, (E) intracellular life, (F) Shiga toxin, and (G) immune response. In this review, an attempt is made to explain the role of each factor inShigellainfection.
Improvement and integration: scientific analyses of willow-leaf shaped bronze swords excavated from the Shuangyuan Village Cemetery, Chengdu, China
Authors: Chen Dian , Yang Yingdong , Wang Tianyou , Wang Xiaoting , Luo Wugan 
Published: June 2022

Abstract
Willow-leaf shaped sword is a kind of exclusive bronze weapon popular only in the states of Ba and Shu during the Eastern Zhou Dynasty (770-256 BC). Its prototype may originate from Central Asia and India and is a typical example of a trans-regional and cross-cultural artifact. Here, we present a scientific study of willow-leaf shaped swords of Shu State from the Shuangyuan Village Cemetery, Chengdu, by pXRF and MC-ICP-MS, and attempted to argue for the improvement and integration of weapon production in Shu by characterizing its elemental composition and lead isotopic signature. The results show that there is a significant difference in the tin content and lead material source between the Ba and Shu bronze swords. This feature can be applied as an important indicator to distinguish willow-leaf shaped swords from Ba and Shu, especially when the appearances are almost confused. The alloy formula of the Shu bronze sword was influenced by the bronze-making technology of Chu and other states. Combining the published lead isotope data of the willow-shaped bronze swords, it can be inferred that Shu State has produced bronze weapons with considerable frequency and in many batches, which was a major motivation for triggering faster progress in its craft.
Stability of transverse dental arch dimension with passive self-ligating brackets: a 6-year follow-up study
Authors: Willeit Franz Josef , Cremonini Francesca , Willeit Paul , Ramina Fabio , Cappelletti Marta , Spedicato Giorgio Alfredo , Lombardo Luca 
Published: June 2022

Abstract
Objective
The stability of the transverse expansion in passive self-ligating bracket treatments is a debated topic in orthodontics. However, to date, only 3 reports are available in the literature, with the maximum follow-up of 3 years after the end of therapy. The present study aims to evaluate the stability of orthodontic treatment with self-ligating brackets in a 6-year follow-up period of time.

Materials and methods
A sample of 56 non-extractive cases (of whom 33 females, mean age 16.9, SD = 9.0 years) consecutively treated with Damon® system was retrospectively selected. All patients received fixed retainers from canine to canine in both arches at the end of treatment, and no removable retainers were provided. The mean values of the transverse intercusp, transverse centroid and transverse lingual distances were evaluated for all teeth from canines to second molars in both arches. Each measure was calculated at four timepoints: before treatment (T0), at the end of treatment (T1), one year after treatment (T2) and six years after treatment (T3). Transverse diameters were measured for all teeth, starting from the canines to the second molars, for a total of 1680 observations, and subsequently compared in order to evaluate intra-treatment and post-treatment modifications.

Results
There were increases in all transverse dental measurements during active treatment. A statistically significant (p < .05) reduction of the transverse diameter was found, for upper and lower premolars, from T1 to T3.

Conclusion
The 6-year follow-up analysis detected that the initial transverse expansion showed a statistically significant relapse in premolars. No relapse was detected at the level of canines, due to the presence of fixed retainers, and minimal at first molars.
Perceived abilities or academic interests? Longitudinal high school science and mathematics effects on postsecondary STEM outcomes by gender and race
Authors: Zhao Teng , Perez-Felkner Lara 
Published: June 2022

AbstractPurpose of the studyPrevious literature has examined the relationship between high school students’ postsecondary STEM major choices and their prior interest and perceived ability in mathematics. Yet, we have limited understanding of whether and how perceived ability and interest in science and mathematics jointly affect students’ STEM major choices.ResultsUsing the most recent nationally representative longitudinal cohort of U.S. secondary school students, we examine the degree to which students’ perceived mathematical and scientific abilities and interests predict their STEM major choices, employing logistic regression and a series of interaction analyses. We find that while both mathematics and science perceived ability positively influence STEM major selection, academic interest in these subjects is a weaker predictor. Moreover, across a series of analyses, we observe a significant gender gap—whereby women are less than half as likely to select STEM majors—as well as nuanced distinctions by self-identified race. The relationships among perceived ability, interest, and STEM major choice are not found to meaningfully vary by race nor consistently by gender. However, perceived ability has a more positive effect for men than women who are pursuing Computing/Engineering majors and a more positive effect for women than men who are pursuing other STEM majors, including less applied Social/Behavioral, Natural, and Other Sciences.ImplicationsThese findings suggest potential opportunities to enhance their perceived mathematical and scientific abilities in high school, positioning them to potentially enter STEM fields. School sites with more resources to support the ambitions of STEM students of all backgrounds may be better positioned to reduce postsecondary disparities in STEM fields. Given existing opportunity gaps and resource differentials among schools, corresponding recommendations are suggested.
Mechanical behavior of hybrid glenoid components compared to all-PE components: a finite element analysis
Authors: Bonnevialle Nicolas , Berhouet Julien , Pôtel Paul , Müller Jacobus Hendrik ,   Shoulder Friends Institute, Godenèche Arnaud 
Published: June 2022

Abstract
Purpose
The purpose of this finite element study was to compare bone and cement stresses and implant micromotions among all-polyethylene (PE) and hybrid glenoid components. The hypothesis was that, compared to all-PE components, hybrid components yield lower bone and cement stresses with smaller micromotions.

Methods
Implant micromotions and cement and bone stresses were compared among 4 all PE (U-PG, U-KG, A-KG, I-KG) and 2 hybrid (E-hCG, I-hPG) virtually implanted glenoid components. Glenohumeral joint reaction forces were applied at five loading regions (central, anterior, posterior, superior and inferior). Implant failure was assumed if glenoid micromotion exceeded 75 µm or cement stresses exceeded 4 MPa. The critical cement volume (CCV) was based on the percentage of cement volume that exceeded 4 MPa. Results were pooled and summarized in boxplots, and differences evaluated using pairwise Wilcoxon Rank Sum tests.

Results
Differences in cement stress were found only between the I-hPG hybrid component (2.9 ± 1.0 MPa) and all-PE keeled-components (U-KG: 3.8 ± 0.9 MPa, p = 0.017; A-KG: 3.6 ± 0.5 MPa, p = 0.014; I-KG: 3.6 ± 0.6 MPa, p = 0.040). There were no differences in cortical and trabecular bone stresses among glenoid components. The E-hCG hybrid component exceeded micromotions of 75 µm in 2 patients. There were no differences in %CCV among glenoid components.

Conclusions
Finite element analyses reveal that compared to all-PE glenoid components, hybrid components yield similar average stresses within bone and cement. Finally, risk of fatigue failure of the cement mantle is equal for hybrid and all-PE components, as no difference in %CCV was observed.

Level of evidence
IV, in-silico.
Anomalous systemic arterial supply to the left basal lung with a calcified abnormal vessel: a case report
Authors: Ebihara Motoki , Fujimori Sakashi , Suzuki Souichiro , Yotsumoto Takuma , Kikunaga Shinichiro , Ohtsuka Reo , Matsuyama Shigefumi 
Published: June 2022

Abstract
Background
Anomalous systemic arterial supply to the normal basal segment of the left lower lobe is a congenital abnormality of the lung, frequently and is generally diagnosed at a young age. Surgery is generally recommended if symptoms such as blood sputum or fever are observed. Resection of the abnormal artery is often performed at an early age, with only few reports of surgery being performed at an older age. In addition, to the best of our knowledge, there are no reports on surgical treatment of abnormal calcified vessels to date. Herein, we have presented a case in which a calcified aberrant vessel of lung was resolved surgically.

Case presentation
A 65-year-old female, previously diagnosed with anomalous systemic arterial supply to the left normal basal segment of the left lung lower lobe of lung was under observation on the basis of being asymptomatic.
The patient presented to the emergency room with the chief complaint of blood in the sputum and she was referred to our hospital for a surgery. Computed tomography showed circumferential calcification of the intima of the abnormal vessel, which might have contributed to incomplete resection of the artery if automatic sutures were used. Thus, the abnormal vessel was ligated and dissected using pledgeted 4–0 polypropylene sutures and vessel clips under open thoracotomy followed by left lower lobectomy. The patient was discharged seven days after surgery without any serious surgical complications.

Conclusions
Vascular congenital anomalies of the lung are often operated at a young age presenting due to the associated symptoms. However, even if the disease is discovered incidentally and does not cause any symptoms or calcification in the aberrant artery, early surgical intervention is important due to the possibility of calcification occuring in the future. This can help minimize the degree of surgical invasion.
Antagonistic activities of endophytic bacteria isolated from rice roots against the fungus Magnaporthe oryzae, a causal of rice blast disease
Authors: Do Quang Trung 
Published: June 2022

Abstract
Background
The blast disease of rice caused by the fungus Magnaphorthe oryzae is one of the most destructive diseases in Nam Dinh province, Vietnam. This study aimed to isolate and screen antagonistic bacteria isolated from the rice (Oryza sativa) against M. oryzae.

Results
In the present study, 14 endophytic bacteria were isolated from rice roots of a Ngoc Xuan variety in Nam Dinh province. The result showed that 6 isolates showed in vitro antagonistic activity against M. oryzae. Of 6, 2 strains, ND06 and ND10, molecularly identified as Bacillus velezensis and Pseudomonas putida, produced a significant inhibition on the pathogenic growth with growth inhibition of 62.87% and 64.25%, respectively, while the other 4 (ND03, ND07, ND09, and ND11) showed a weak inhibition. In addition, the ND06 and ND10 strains also presented antagonistic activity against M. oryzae under greenhouse conditions. Moreover, screening plant growth-promoting (PGP) traits of 2 isolates exhibited all 5 PGP traits including IAA production, phosphate solubilization, and production of ammonia, 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase, and siderophore. In addition, the greenhouse experimental results indicated that the cultivar rice seedlings inoculated with ND06 or ND10 strain produced a significant enhancement of the agronomic parameters (root length, shoot length, dry matter, and chlorophyll content).

Conclusions
The results indicated that the rice root endophytic bacteria (ND06 and ND10) possessed contemporarily multiple PGP traits and antifungal activity. These 2 strains should be further characterized in order to confirm the beneficial traits to develop as a potential biofertilizer and/or biocontrol agent for rice sustainable production.
Bilateral Brown-Sequard syndrome regressing to anterior cord syndrome in spinal impalement: 2 unique cases with management pearls
Authors: Siroya Hardik Lalit , Juneja Mohit , Rao Anirudh J. , Chauhan Sonal , Bhat Dhananjaya Ishwar , Devi Bhagavatula Indira 
Published: June 2022

Abstract
Background
Non-missile impalement spine injuries are quite uncommon. Most of these patients either present with impaling agent in situ or with a part of retained offending agent. Both the scenarios present unique management challenges especially if patients are clinically stable. The injury becomes more complex if multiple compartments like lung and abdomen also get involved. Non-missile penetrating spinal injury is rarely seen in the Indian settings. The world over it approximately accounts for 0.3–2.1% of spinal injuries. In view such meagre occurrence management decisions are usually driven based on surgeons’ experience and patient’s condition. Although conservative approaches for retained products have less complications as compared to surgery, long-term outcomes are not available for comparison. Unique management challenges are noted and described. Physical doctrines for management principles of such injuries are also attempted. Noteworthy is that their regression from complete cord syndrome to anterior cord syndrome is extremely short period.

Case presentation
We present 2 unique cases presenting as complete cord transection regressing from bilateral brown Sequard syndrome to anterior cord syndrome following decompression.

Conclusion
Spinal impalements are very rare especially now with strict societal regulations and criminal justice in place. Still now and then we do come across some staggering cases as described above. To establish a treatment protocol and management guidelines in such scarce scenarios is difficult. We attempt to underlie few basic doctrines in this regard with our experience in a tertiary centre.
Computational pathology, new horizons and challenges for anatomical pathology
Authors: dos-Santos Washington L. C. , de Freitas Luiz A. R. , Duarte Angelo A. , Angelo Michele F. , Oliveira Luciano R. 
Published: June 2022

AbstractThe emergence of digital pathology environments and the application of computer vision to the analysis of histological sections has given rise to a new area of Anatomical Pathology, termed Computational Pathology. Advances in Computational Pathology may substantially change the routine of Anatomical Pathology laboratories and the work profile of the pathologist.