bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protective Effect of Purinergic P2X7 Receptor Inhibition on Acrolein-Induced Urothelial Cell Damage
Authors: Taidi Zhinoos , Mansfield Kylie J. , Sana-Ur-Rehman Hafiz , Moore Kate H. , Liu Lu 
Published: April 2022

Patients undergoing chemotherapy with cyclophosphamide experience cystitis due to excretion of a toxic metabolite, acrolein. Cystitis, an inflammation of the bladder, is associated with damage to the integrity of the urothelial barrier. The purinergic P2X7 receptor (P2X7R) is increasingly recognized for its role in inflammation and cell death. P2X7R is expressed abundantly on the bladder urothelium. The aim of this study was to investigate the role of P2X7R in acrolein-induced inflammatory damage in primary cultured porcine bladder urothelial cells. Confluent urothelial cells in culture were treated with acrolein to induce damage; also, with the P2X7R selective antagonist, A804598. Cell viability assay, immunocytochemistry, and trans-epithelial electrical resistance (TEER) studies were carried out to investigate the effect of treatments on urothelial cell function. Acrolein induced a significant reduction in urothelial cell viability, which was protected by the presence of A804598 (10 µM). The urothelial barrier function, indicated by TEER values, was also significantly reduced by acrolein, whereas pre-incubation with P2X7R antagonist significantly protected the urothelial cell barrier from acrolein-induced TEER reduction. The structure of urothelial cell tight junctions was similarly impacted by acrolein treatment, showing the fragmentation of zona occludens-1 (ZO-1) immunoreactivity. Pre-treatment of cells with A804598 countered against the actions of acrolein and maintained ZO-1 expression level and cell structure. The damaging effect of acrolein on urothelial cells integrity could be impaired by inhibition of P2X7R, therefore P2X7R blockade may be a possible therapy in patients with bladder cystitis caused by cyclophosphamide treatment.
Identifying Electroencephalography Biomarkers in Individuals at Clinical High Risk for Psychosis in an International Multi-Site Study
Authors: Kerins Sarah , Nottage Judith , Salazar de Pablo Gonzalo , Kempton Matthew J. , Tognin Stefania , Niemann Dorien H. , de Haan Lieuwe , van Amelsvoort Thérèse , Kwon Jun Soo , Nelson Barnaby , Mizrahi Romina , McGuire Philip , Fusar-Poli Paolo ,   The PSYSCAN Consortium
Published: April 2022

BackgroundThe clinical high-risk for psychosis (CHR-P) paradigm was introduced to detect individuals at risk of developing psychosis and to establish preventive strategies. While current prediction of outcomes in the CHR-P state is based mostly on the clinical assessment of presenting features, several emerging biomarkers have been investigated in an attempt to stratify CHR-P individuals according to their individual trajectories and refine the diagnostic process. However, heterogeneity across subgroups is a key challenge that has limited the impact of the CHR-P prediction strategies, as the clinical validity of the current research is limited by a lack of external validation across sites and modalities. Despite these challenges, electroencephalography (EEG) biomarkers have been studied in this field and evidence suggests that EEG used in combination with clinical assessments may be a key measure for improving diagnostic and prognostic accuracy in the CHR-P state. The PSYSCAN EEG study is an international, multi-site, multimodal longitudinal project that aims to advance knowledge in this field.MethodsParticipants at 6 international sites take part in an EEG protocol including EEG recording, cognitive and clinical assessments. CHR-P participants will be followed up after 2 years and subcategorised depending on their illness progression regarding transition to psychosis. Differences will be sought between CHR-P individuals and healthy controls and between CHR-P individuals who transition and those who do not transition to psychosis using data driven computational analyses.DiscussionThis protocol addresses the challenges faced by previous studies of this kind to enable valid identification of predictive EEG biomarkers which will be combined with other biomarkers across sites to develop a prognostic tool in CHR-P. The PSYSCAN EEG study aims to pave the way for incorporating EEG biomarkers in the assessment of CHR-P individuals, to refine the diagnostic process and help to stratify CHR-P subjects according to risk of transition. This may improve our understanding of the CHR-P state and therefore aid the development of more personalized treatment strategies.
Hepatitis B Infection Among Pregnant Women in China: A Systematic Review and Meta-Analysis
Authors: Liu Dan , Liu Yan , Ni Jiaqi , Li Hailong , Zeng Linan , Zhang Chuan , Zhang Li , Yu Qin , Wu Bin , Zhang Lingli 
Published: April 2022

BackgroundA study of the current situation and characteristics of hepatitis B virus (HBV) infection among Chinese pregnant women is meaningful to provide baseline information for future research and policy making, with an aim to eliminate HBV in China.ObjectivesTo provide the epidemiological status of HBV infection among pregnant women in China.MethodsPubMed, EMbase, The Cochrane Library, and three Chinese databases were searched. Cohort studies and cross-sectional studies on HBV prevalence in Chinese pregnant women, published after 2016, were retrieved. In addition, combined HBV prevalence and 95% confidence interval (CI) were calculated. This research was registered in PROSPERO (CRD42021289123).Main ResultsA total of 42 studies were included in the study, with a sample size of 4,007,518 cases, and 20 provinces in China. The prevalence of HBV in Chinese pregnant women was 6.64% (95% CI: 5.72–7.57%) during the period between 2016 and 2021. Among HBsAg positive pregnant women, the HBeAg positive rate was 25.80% (95% CI: 22.26–29.69%). Moreover, geographic regions with HBV prevalence ranking from high to low were in western China, eastern China, and central China, successively.ConclusionThe prevalence of HBV in Chinese pregnant women is intermediate endemic, although disparities exist between different regions. Among pregnant women with HBV infection, a high proportion of the patients have strong infectivity. Factors affecting HBV prevalence remain controversial, which demands further studies.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42021289123.
Unique Observational Constraints on the Seasonal and Longitudinal Variability of the Earth’s Planetary Albedo and Cloud Distribution Inferred From EPIC Measurements
Authors: Carlson Barbara E. , Lacis Andrew A. , Russell Gary L. , Marshak Alexander , Su Wenying 
Published: April 2022

Thorough comparison to observations is key to developing a credible climate model forecasting capability. Deep Space Climate Observatory (DSCOVR) measurements of Earth’s reflected solar and emitted thermal radiation provide a unique observational perspective that permits a more reliable model/data comparison than is possible with the otherwise available satellite data. The uniqueness is in the DSCOVR satellite’s viewing geometry, which enables continuous viewing of the Earth’s sunlit hemisphere from its Lissajous orbit around the Lagrangian L1 point. The key instrument is the Earth Polychromatic Imaging Camera (EPIC), which views the Earth’s sunlit hemisphere with 1024-by-1024-pixel imagery in 10 narrow spectral bands from 317 to 780 nm, acquiring up to 22 high spatial resolution images per day. The additional feature is that the frequency of EPIC image acquisition is nearly identical to that of the climate GCM data generation scheme where climate data for the entire globe are ‘instantaneously’ calculated at 1-h radiation time-step intervals. Implementation of the SHS (Sunlit Hemisphere Sampling) EPIC-view geometry for the in-line GCM output data sampling establishes a precise self-consistency in the space-time data sampling between EPIC observational and GCM output data generation and sampling. The remaining problem is that the GCM generated data are radiative fluxes, while the EPIC measurements are backscatter-dependent radiances. Radiance to flux conversion is a complex problem with no simple way to convert GCM radiative fluxes into spectral radiances. The more expedient approach is to convert the EPIC spectral radiances into broadband radiances by MODIS/CERES-based regression relationships and then into solar radiative fluxes using the CERES angular distribution models. Averaging over the sunlit hemisphere suppresses the meteorological weather noise, but preserves the intra-seasonal larger scale variability. Longitudinal slicing by the Earth’s rotation permits a self-consistent model/data comparison of the longitudinal model/data differences in the variability of the reflected solar radiation. Ancillary EPIC Composite data provide additional cloud property information for climate model diagnostics. Comparison of EPIC-derived seasonal and longitudinal variability of the Earth’s planetary albedo with the GISS ModelE2 results shows systematic overestimate of cloud reflectivity over the Pacific Ocean with corresponding underestimates over continental land areas.
Провокація кримінального правопорушення: порівняльно-правовий аспект
Authors: Каменський Д. 
Published: April 2022

У науковій статті здійснено авторську спробу проаналізувати, з позицій юридичної компаративістики, проблематику провокації кримінального правопорушення, спираючись на релевантні законодавчі та правозастосовні джерела в Україні та деяких інших державах.
На підставі активного звернення до попередньої законотворчої роботи та опрацювання відповідного зарубіжного досвіду, спрогнозовані деякі перспективи вдосконалення міжгалузевого інституту провокації. Висвітлено доречні історичні та міжнародні аспекти проблематики, розглянуто позиції американських та європейський авторів щодо визначення ознак та меж допустимості провокації. Показано, що кожна держава намагається винайти свій власний, самобутній підхід до юридичної оцінки правоохоронної провокації.
Rancangan Strategi Bisnis PT.Pel Berlian Pulau Mandangin Tahun 2021 – 2023
Authors: Rohman Abdur Rohman , Hidayati Aprihatiningrum 
Published: April 2022

This thesis discusses about the business strategy design 2021 - 2023 period. The formulation of business strategy is carried out by conducting an external analysis, in order to obtain opportunities and threats that can affect the shipping industry, then formulate the strengths and weaknesses of PT. BPM, then performs the formulation of alternative strategies using internal and external analysis (IE) and the TOWS Matrix. And in order to obtain several alternative strategic options. The last step is choosing a strategy using the Quantitative Strategic Planning Matrix (QSPM). QSPM analysis shows that the selected strategy for the 2021 - 2023 period is a product development and planning business implementation of the chosen strategy.
Strategi Bisnis Kewirausahaan Sosial ABC Periode 2021-2023
Authors: Hastono Diatrhi , Hidayati Aprihatiningrum 
Published: April 2022

ABC is a social enterprise that gives training and coaching for business and management also provide mentoring for orphans to start their own business and acting as the linkage between the market and the orphans’ products. Hence, ABC needs a platform such as marketplace by 2023. To achieve this target, ABC has to build business and functional strategies to make the target comes true. ABC does external analysis by using PESTEL, Porter’s Five Forces, Competitor Profile Matrix, and Decision-Making Process. The internal analysis held by using 7S McKinsey. ABC also analyze any impact and map the stakeholder priority. Based on all the analysis, the business strategy for 2021 to 2023 was built and named as Strategi BANGUN. For 2021, ABC has to confirm its curriculum and the marketplace concept. In the next year, ABC has to build its management system and gain some external fundings. By the end of 2023, ABC has to launch its own marketplace. These strategies need be supported by the functional strategies to be achieved. If all the business strategies could be achieved, then ABC’s target to have its own marketplace by 2023 will be fulfilled.
Buschke – Fisher – Brauer Keratoderma
Authors: Козин В.М. , Козина Ю.В. 
Published: April 2022

Наследственные кератодермии редко встречаются в практике врача-дерматолога и вызывают затруднения при диагностике. Учитывая редкие случаи ладонно-подошвенной кератодермии Бушке – Фишера – Брауэра, авторы приводят описание клинических проявлений, патогистологии образцов, лечения и наблюдения за пациенткой Е.И.В., 49 лет, с жалобами на жемчужные гиперкератотические высыпания в течение 20 лет на коже верхних и нижних конечностей без субъективных ощущений. При необходимости подтверждения точечной кератодермии проводят специальные генетические исследования (α- и γ-адаптин-связывающий белок), ПЦР-исследования на ВПЧ. Терапию пациентке назначают не менее 2 раз в год (системные ретиноиды, ангиопротекторы, применение 5–10%-ной салициловой мази, кремов и мазей на основе мочевины), необходим постоянный уход за кожей кистей и стоп – мыльно-содовые ванночки, использование эмолентов, ношение мягкой, не травмирующей кожу обуви, иногда ношение ортопедической обуви, санаторно-курортное лечение.
Hereditary Buschke – Fisher – Brauer keratoderma is rare in the practice of a dermatologist and causes the diagnostic difficulties. Taking into consideration the rare cases of palmar- plantar Bushke – Fischer – Brauer keratoderma, the authors provide a description of the clinical manifestations, pathology of the samples, treatment and monitoring of the patient E.I.V., 49 years old, with complaints of pearl hyperkeratotic rashes on the upper and lower limbs, without subjective sensations during 20 years.If it is necessary to confirm point keratoderma, special genetic studies (α and γ-adaptin-binding protein), PCR studies on HPV are performed.The patient is prescribed therapy at least 2 times a year (systemic retinoids, angioprotectors, the use of 5–10% salicylic ointments, creams and ointments based on urea), constant care for the skin on the soles of the feet and palms of the hands – soap-soda baths, the use of emollients, wearing soft shoes, that do not cause the damage of the skin, sometimes wearing orthopedic shoes, so as spa treatment.
Analysis of interrelations of individual Psychological Characteristics of Pregnant Women and indices of Psychological Adaptation to Pregnancy
Authors: Василенко Т.Д. , Дремина Т.Ф. 
Published: April 2022

В статье представлены результаты корреляционного и регрессионного статистического анализа индивидуально-личностных особенностей беременных женщин и показателей психологической адаптации беременных женщин в зависимости от наличия опыта материнства (позитивного, представленного наличием первого ребенка, и негативного, представленного опытом невынашивания беременности) в контексте жизненного пути личности. В нашем исследовании мы предполагаем, что беременная женщина обладает определенными индивидуально-психологическими особенностями, которые влияют на успешность адаптации к новой жизненной ситуации – беременности.В исследовании приняли участие 159 беременных женщин с различным опытом материнства (ожидающие первого ребенка, ожидающие второго ребенка и женщины, имеющие опыт невынашивания беременности (выкидыш)). Выборку составили беременные женщины, ожидающие первого ребенка, и женщины, имеющие опыт невынашивания беременности (выкидыш), в возрасте 22–27 лет (как нормородящие) и беременные женщины, ожидающие второго ребенка, в возрасте 28–32 года (как позднородящие).Результаты нашего исследования показали, что для беременных женщин с различным опытом материнства характерен специфичный комплекс индивидуально-психологических особенностей, которые помогают нам существенно дополнить представления об адаптации к беременности.
The article presents the results of correlational and regression statistical analysis of individual psychological characteristics of pregnant women and indices of psychological adaptation of pregnant women depending on the experience of motherhood (positive, represented by thepresence of the first child, and negative, represented by the experience of miscarriage) in the context of personality’s life journey. In our study, we suppose that a pregnant woman has certain individual psychological characteristics that have an impact on success of adaptation to a new reality situation – pregnancy. the study included 159 pregnant women with different maternity experience (expecting the first child, expecting the second child, and women with experience of miscarriage (abortion)). the sample consisted of pregnant women, expecting the first child and women with the experience of miscarriage (abortion) at the age of 22–27 years (as normal child bearing), and pregnant women, expecting the second child at the age of 28–32 years (as late child bearing).the results of our study showed that pregnant women with different experience of motherhood are characterized by a specific complex of individual psychological characteristics that help to supplement the view of adaptation to pregnancy fundamentally.
Psychological Factors in the Development of Cardiovascular Diseases at Different stages of Life
Authors: Березина Т.Н. 
Published: April 2022

Цель исследования: изучение психологических факторов, влияющих на риск возникновения сердечно-сосудистых заболеваний при разных условиях.Методы исследования: естественный эксперимент, близнецовый метод. Были изучены две выборки испытуемых, соответствующих разным условиям:1) 100 пар монозиготных близнецов, уже завершивших жизненный путь, среди которых было 16 пар, в которых один из близнецов умер от острой формы сердечно-сосудистого заболевания во взрослом возрасте;2) 254 человека старше 70 лет, страдающих хроническим сердечно-сосудистым заболеванием, из которых 15 человек умерли в течение 1 года после обследования. У всех испытуемых были изучены особенности жизненного пути и личности или с помощью анкетирования, или посредством опроса родственников. Результаты: развитие острых форм сердечно-сосудистых заболеваний во взрослом возрасте связано с особенностями поведения типа А (целеволевые качества личности, общительность, наличие детей). Прогрессирование хронического заболевания в пенсионном возрасте усиливали нездоровый образ жизни и вредные привычки. Развитие смертельных форм хронического заболевания в пожилом возрасте: риск усиливался при слишком низком и высоком оптимизме, а развитие целеволевых черт, общительности и карьерные достижения выступали ресурсом, снижающим риск.
Abstractthe aim of the study was to study the psychological factors that affect the risk of cardiovascular disease under different conditions. Research methods: natural experiment, twin method. We studied two samples of subjects corresponding to different conditions: 1) 100 pairs of monozygotic twins who had already completed their life journey, among whom there were 16 pairs in which one of the twins died of an acute form of cardiovascular disease in adulthood, 2) 254 people older 70 years old suffering from chronic cardiovascular disease, of which 15 people died within 1 year after the examination. all subjects examined the characteristics of their life paths and personality either bymeans of questionnaires or by interviewing relatives. Results: the development of acute forms of cardiovascular disease in adulthood is associated with the characteristics of type a behavior (goal-oriented personality traits, sociability, the presence of children). Progression of a chronic disease in retirement age was reinforced by an unhealthy lifestyle and bad habits. the development of fatal forms of a chronic disease in old age: the risk increased with too low and high optimism, and the development of goal-oriented traits, sociability, and career achievements were a resource that reduced risk.
Non-demential Cognitive Disorders in Patients with epilepsy: Current state of the Problem
Authors: Коростий В.И. , Блажина И.Ю. 
Published: April 2022

Введение. Изучение когнитивных расстройств вследствие неврологических и психических заболеваний представляет особый интерес в связи с большой распространенностью данной патологии и существенным влиянием на качество жизни пациентов и их социальную адаптацию.Цель. Изучение современного состояния проблемы нарушения когнитивных функций у пациентов, которые страдают эпилепсией, выявление факторов, влияющих на когниции.Материалы и методы. Проведен обзор и теоретический анализ первоисточников и современных научных исследований в области когнитивных нарушений при эпилепсии.Результаты. В данной публикации представлен всесторонний обзор научной литературы по поводу современного состояния проблемы когнитивных нарушений у пациентов, страдающих эпилепсией. Освещены результаты научных исследований в области этиопатогенетических факторов, оказывающих влияние на когнитивные функции.Выводы. Когнитивная дисфункция при эпилепсии является многофакторной по своей сути. Локализация и характер поражения, частота и вид эпилептических припадков, преморбидные характеристики пациентов, аффективные и поведенческие расстройства, характерологические изменения, побочные эффекты противосудорожных препаратов, течение заболевания, гендерные признаки и экзогенные заболевания оказывают влияние и обуславливают возникновение и прогрессирование когнитивного дефицита, который в свою очередь существенно влияет на качество жизни пациентов, их работоспособность и социализацию.
Introduction. the study of cognitive impairment due to neurological and mental illness is of particular interest because of the high prevalence of this pathology and significant impact on the quality of life of patients and their social adaptation.Purpose. the study of current state of the problem of cognitive impairment in patients with epilepsy, identification of factors that affect cognitions.Materials and methods. the review and theoretical analysis of primary sources and modern scientific researches in the field of cognitive impairments in epilepsy was carried out.Results. this publication offers a comprehensive review of scientific literature on the current state of the problem of cognitive impairment in patients with epilepsy. the results of scientific researches in the field of etiopathogenetic factors that influence cognitive functions are presented.Conclusions. Cognitive dysfunction during epilepsy is multifactorial in nature. localization and nature of disorder, frequency and type of epileptic seizures, premorbid characteristics of patients, affective and behavioural disorders, characterological changes, side effects of anticonvulsant drugs, course of the disease, gender characteristics, and exogenous diseases affect and lead to the occurrence and progression of cognitive deficits, which significantly affects the quality of life of patients, their ability to work and socialize.