bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Modeling of Spray G ECN Using ROI-Based Eulerian-Lagrangian Simulation
Authors: Ailaboina Akhil , Saha Kaushik 
Published: July 2022

A numerical study has been carried out to understand the effects of Unsteady Reynolds Averaged Navier-Stokes (standard k ― ε and RNG k ― ε model) and large eddy simulations (LES) on a multi-hole gasoline direct injection (GDI) system. The fuel injector considered in this study is the Spray G nozzle from the Engine Combustion Network (ECN). A blob injection model, based on empirical rate of injection (ROI) profile, is considered in this study. The latest data on spray penetrations from Engine Combustion Network is used for model validation along with experimental findings on suction velocity and local droplet diameter. The spray breakup is simulated by using the KH-RT breakup length model. The turbulence model constant Cε1, is tuned to match with the experimental data of liquid and vapor penetrations in simulations while using the standard k-ε turbulence model. On the other hand, the Kelvin-Helmholtz breakup model time constant (B1) and Rayleigh Taylor breakup length constant (Cbl) are tuned for the RNG k ― ε turbulence model. From this work it is observed that by increasing the breakup length model constants (Cbl), the radial dispersion of the spray increases, and the extent of breakup is lowered. The set of optimized model parameters used with RNG k - ε is also used for LES modeling studies with different sub-grid models. The spray penetrations with standard k ― ε turbulence (Cε1=1.44) model are reported underpredicting, and the RNG k ― ε and LES sub-grid models predicted well with the latest and recommended data from ECN. In terms of gas axial velocity comparison, the standard k-ε(Cε1=1.44) simulation setup does not perform as well as the simulation setups using RNG k-ε and LES turbulence models (with breakup parameters: Cbl = 16 and B1 = 32). However, the standard k-ε(Cε1=1.44) simulation setup perform better than the simulation setups using RNG k-ε and LES turbulence models (with breakup parameters: Cbl = 16 and B1 = 32) when it comes to predicting local droplet diameter at 15 mm downstream of the injector tip. A parametric study is also performed considering the geometry of the stepped holes in the computational domain. The rate of injection based simulation is initiated at the end of the smaller hole. The case including the stepped holes led to over-prediction compared to the case with the usual computational domain (i.e., without the stepped holes), in terms of spray penetrations, but exhibited higher levels of fluctuations in the spray morphology. Finally, parametric studies were carried out to understand the relative importance of the individual spray sub-models (breakup, evaporation and collision) and the results are conclusive that for a spray simulation the breakup models are the dominant factors.
Convergent functional changes of the episodic memory impairment in mild cognitive impairment: An ALE meta-analysis
Authors: Liang Xuhong , Yuan Qianqian , Xue Chen , Qi Wenzhang , Ge Honglin , Yan Zheng , Chen Shanshan , Song Yu , Wu Huimin , Xiao Chaoyong , Chen Jiu 
Published: July 2022

BackgroundMild cognitive impairment (MCI) is considered to be an intermediate stage between normal aging and Alzheimer's disease (AD). The earliest and most common symptom of MCI is impaired episodic memory. When episodic memory is impaired in MCI patients, specific functional changes occur in related brain areas. However, there is currently a lack of a unified conclusion on this change. Therefore, the purpose of this meta-analysis is to find MRI-specific functional changes in episodic memory in MCI patients.MethodsBased on three commonly used indicators of brain function: functional connectivity (FC), the amplitude of low-frequency fluctuation /fractional amplitude of low-frequency fluctuation (ALFF/fALFF), and regional homogeneity (ReHo), we systematically searched PubMed, Web of Science and Ovid related literature and conducted the strict screening. Then we use the activation likelihood estimation (ALE) algorithm to perform the coordinate-based meta-analysis.ResultsThrough strict screening, this meta-analysis finally included 21 related functional neuroimaging research articles. The final result displays that functional changes of episodic memory in MCI patients are mainly located in the parahippocampal gyrus, precuneus, posterior cingulate gyrus, cuneus, middle temporal gyrus, middle frontal gyrus, lingual gyrus, and thalamus.ConclusionsThere are specific functional changes in episodic memory brain regions in MCI patients, and the brain functional network can regulate episodic memory through these brain regions. And these specific changes can assist in the early diagnosis of MCI, providing new ideas and directions for early identification and intervention in the process of MCI.
Auditory Manifestations of Vestibular Migraine
Authors: Shi Suming , Wang Dan , Ren Tongli , Wang Wuqing 
Published: July 2022

ObjectivesTo investigate the auditory features of patients with vestibular migraine (VM) and to analyze the possible relevant factors of hearing loss.MethodsA total of 166 patients with VM were enrolled. Demographic variables, age of onset, disease course, distribution of vestibular attacks, characteristics of hearing loss, and the coexistence of related disorders, such as visual aura, familial history, motion sickness, nausea, headache, photophobia, otalgia, tinnitus, aural fullness, and phonophobia, were analyzed and compared.ResultsPatients with VM can manifest otalgia (8.4%), tinnitus (51.8%), aural fullness (41%), and phonophobia (31.9%). Of 166 patients, the prevalence of VMw was 21.1% (n = 35). Patients with VMw mainly manifested mild and easily reversible low-frequency hearing loss. The proportions of tinnitus and aural fullness were significantly larger in patients with VMw than that in patients with VMo (P &lt; 0.05). The duration of vestibular symptoms was significantly shorter in patients with VMw (P &lt; 0.05). However, the age of onset, disease course, gender, frequency of vestibular attacks, the coexistence of visual aura, familial history, motion sickness, nausea, headache, photophobia, otalgia, and phonophobia had no significant difference between the two groups.ConclusionAuditory symptoms were common in patients with VM. The hearing loss of VM was characterized by a mild and easily reversible low-frequency hearing loss, accompanied by higher proportions of tinnitus and aural fullness, and a shorter duration of vestibular symptoms compared with patients with VMo.
Comparison of high flow nasal cannula and non-invasive positive pressure ventilation in children with bronchiolitis: A meta-analysis of randomized controlled trials
Authors: Zhong Zhaoshuang , Zhao Long , Zhao Yan , Xia Shuyue 
Published: July 2022

BackgroundThe effects of high-flow nasal cannula (HFNC) compared to non-invasive positive pressure ventilation (NIPPV) on children with bronchiolitis remain unclear.MethodsThis meta-analysis was performed following the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement. Randomized controlled trials (RCTs) were identified from a comprehensive search in PubMed, EMBASE, Cochrane Library, and Web of Science without time and language limitations. Primary endpoints include the rate of treatment failure, the rate of need for intubation, and the pediatric intensive care unit (PICU) length of stay.ResultsFive RCTs including 541 children of less than 24 months were enrolled in the meta-analysis. Compared to the NIPPV group, the rate of treatment failure was significantly higher in the HFNC treatment group (I2 = 0.0%, P = 0.574; RR 1.523, 95% CI 1.205 to 1.924, P &lt; 0.001). No significant difference was noted in the need for intubation (I2 = 0.0%, P = 0.431; RR 0.874, 95% CI 0.598 to 1.276, P = 0.485) and the PICU length of stay (I2 = 0.0%, P = 0.568; WMD = –0.097, 95% CI = –0.480 to 0.285, P = 0.618) between the HFNC group and the NIPPV treatment.ConclusionCompared to the NIPPV group, HFNC therapy was associated with a significantly higher treatment failure rate in children suffering from bronchiolitis. The intubation rate and the PICU length of stay were comparable between the two approaches.
Zi Shen Wan Fang Attenuates Neuroinflammation and Cognitive Function Via Remodeling the Gut Microbiota in Diabetes-Induced Cognitive Impairment Mice
Authors: Shi Jiangwei , Yin Qingsheng , Zhang Lin , Wu Yu , Yi Pengrong , Guo Mengqing , Li Huhu , Yuan Liuyi , Wang Zixuan , Zhuang Pengwei , Zhang Yanjun 
Published: July 2022

Background: Cognitive dysfunction is a critical complication of diabetes mellitus, and there are still no clinically approved drugs. Zi Shen Wan Fang (ZSWF) is an optimized prescription composed of Anemarrhenae Rhizoma, Phellodendri Chinensis Cortex, and Cistanches Herba. The purpose of this study is to investigate the effect of ZSWF on DCI and explore its mechanism from the perspective of maintaining intestinal microbial homeostasis in order to find an effective prescription for treating DCI.Methods: The diabetes model was established by a high-fat diet combined with intraperitoneal injections of streptozotocin (STZ, 120 mg/kg) and the DCI model was screened by Morris water maze (MWM) after 8 weeks of continuous hyperglycemic stimulation. The DCI mice were randomly divided into the model group (DCI), the low- and high-ZSWF–dose groups (9.63 g/kg, 18.72 g/kg), the mixed antibiotic group (ABs), and the ZSWF combined with mixed antibiotic group (ZSWF + ABs). ZSWF was administered orally once a day for 8 weeks. Then, cognitive function was assessed using MWM, neuroinflammation and systemic inflammation were analyzed by enzyme-linked immunosorbent assay kits, intestinal barrier integrity was assessed by hematoxylin-eosin (HE) staining and Western blot and high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Furthermore, the alteration to intestinal flora was monitored by 16S rDNA sequencing.Results: ZSWF restored cognitive function in DCI mice and reduced levels of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α. Moreover, ZSWF protected the integrity of the intestinal barrier by increasing intestinal ZO-1 and occludin protein expression and decreasing urinary lactulose to mannitol ratio. In addition, ZSWF reshaped the imbalanced gut microbiota in DCI mice by reversing the abundance changes of a wide range of intestinal bacteria at the phyla and genus levels. In contrast, removing gut microbiota with antibiotics partially eliminated the effects of ZSWF on improving cognitive function and reducing inflammation, confirming the essential role of gut microbiota in the improvement of DCI by ZSWF.Conclusion: ZSWF can reverse cognitive impairment in DCI mice by remolding the structure of destructed gut microbiota community, which is a potential Chinese medicine prescription for DCI treatment.
Changing Characteristics of Pharmaceutical Prices in China Under Centralized Procurement Policy: A Multi-Intervention Interrupted Time Series
Authors: Long Hongfei , Yang Ying , Geng Xin , Mao Zongfu , Mao Zhenhua 
Published: July 2022

Objective: National centralized drug procurement organized by the Chinese government currently represents the largest group purchasing organization worldwide, to establish a reasonable price formation mechanism. This study aimed to evaluate the effects of centralized procurement policy on drug price and price ratio in China.Method: Monthly drug procurement data of public medical institutions were extracted from the national procurement database, including 11 pilot cities and 36 months from January 2018 to December 2020. Centralized procured INNs (International Nonproprietary Names) (n= 25) and their alternative INNs (n= 96) were selected as study samples. Centralized procured INNs were divided into bid-winning and non-winning products according to the bidding results. Drug price, price distribution, and price ratio were measured. Multi-intervention interrupted time series analysis was performed to estimate the policy impacts in two centralized procurement periods.Results: The price of centralized procured INNs showed an immediate drop of 44.57% (β= -0.59,p&lt; 0.001) at the policy implementation, among which bid-winning drugs decreased by 61.71% (β= -0.96,p&lt; 0.001). No significant change in the price level or trends was found for non-winning products and alternative drugs in the first-year procurement period (allp-values &gt; 0.05). During the second-year procurement period, alternative drugs in four therapeutic categories detected significant increases in the price level (allp-values &lt; 0.05). The overall coefficient of variation of price distribution exhibited upward trends after policy implementation. Among the most centralized procured INNs, the price ratio between certificated generics (generics that have passed the consistency evaluation) and original drugs declined significantly after policy intervention (p&lt; 0.05), whereas the price ratio between uncertificated and certificated generics increased significantly (p&lt; 0.05).Conclusion: Chinese government-organized group purchasing resulted in prominent price reduction of bid-winning drugs. The policy observed a short-term “spillover” effect of synergistic price reduction, while the effect wore off after 1-year procurement period. The extremely dispersed price distribution, as well as unreasonable price ratios, requires further effective price regulation means.
Influence of Workload, Personality, and Psychological Flexibility on Occupational Stress Among Medical Staff: A Fuzzy-Set Qualitative Comparative Analysis
Authors: Quan Liming , Zhang Yang , Jiang Fugui , Liu Ying , Lan Yajia , Huang Lei 
Published: July 2022

ObjectiveDuring the COVID-19 pandemic, the occupational stress of medical staff has been a major issue. This study aimed to suggest a new strategy to identify high-risk factor sets of occupational stress in medical staff using fuzzy-set qualitative comparative analysis (fs-QCA) and provide ideas for the prevention and intervention of occupational stress.MethodsA total of 1,928 medical staff members were surveyed and tested using the Acceptance and Action Questionnaire-II (AAQ-II), Occupational Stress Inventory-Revised edition (OSI-R), and Eysenck Personality Questionnaire-Revised Short Scale (EPQ-RSC). The fs-QCA was used to explore the high-risk factors for occupational stress among medical staff.ResultsThe psychological strain (PSY) score of the medical staff was 26.8 ± 7.13, and the physical strain (PHS) score was 24.3 ± 6.50. Low psychological flexibility score-introversion-high role overload, introversion-neuroticism-high role overload, and low psychological flexibility score-neuroticism were high-risk factor sets for PSY. Low psychological flexibility score-introversion-high role overload, low psychological flexibility score-introversion-neuroticism, low psychological flexibility score-neuroticism-high role overload, low psychological flexibility score-psychoticism-neuroticism, and psychoticism-neuroticism-high role overload were high-risk factor sets for PHS.ConclusionThere are different combinations of high-risk factors for occupational stress among the medical staff. For occupational stress intervention and psychological counseling, targeted and individualized health intervention measures should be implemented according to specific characteristic combinations of different individuals.
Consumers' Perception About Front of Package Food Labels (FOPL) in India: A Survey of 14 States
Authors: Bhattacharya Sudip , Bera Om Prakash , Shah Vandana 
Published: July 2022

IntroductionFront of Package Food Labels (FoP) help consumers make healthier food choices at the point of purchase by giving details about the nutrients available in the packaged food items.Aim and ObjectiveA prospective multi-centric cross-sectional study was conducted in 2021 across India to evaluate the existing knowledge and attitude regarding food labels on packaged foods and beverages. Also, the objective understanding of the consumers' knowledge on different types of FoP label practiced across the world was determined.MethodologyA self-administered questionnaire was given to the respondents to gather their attitudes regarding the FoP label. Besides, they were given colored pictures of different FoP labels to seek their perception and preference for different FoP label designs.ResultsResults found that packaged food and beverages were consumed by 91.3% of the participants. Awareness about the food package labeling was widely held by 95% of the participants and 88.6% of them considered this information helpful. Over half (55.4%) of the respondents considered packaged foods as healthy. Warning Labels (WL) were the most preferred food labels (93%), followed by Multiple Traffic Lights (MTL) and the difference between the two was statistically significant (p-value &lt; 0.05).ConclusionsThe awareness about FoP labels is low among the consumers.RecommendationsEvidence-based research is recommended regarding the knowledge and perception of people on the feasibility of FoP label design which may lay a foundation to formulate laws and policies regarding the front of pack labeling.
Expression of CD44, Transforming Growth Factor-β, and Matrix Metalloproteinases in Women With Pelvic Organ Prolapse
Authors: Ying Weiwei , Hu Yanping , Zhu Haibin 
Published: July 2022

BackgroundDefects in the pelvic floor connective tissue may underlie the etiology of pelvic organ prolapse (POP). We hypothesized that the expression of proteins regulating extracellular matrix turnover is altered in the uterosacral ligament of women with POP. We compared the expression of CD44, transforming growth factor (TGF)-β, and matrix metalloproteinases (MMPs) 2/9 in women with and without POP.Methods and ResultsThis matched case-control study included 30 postmenopausal women, with POP stage 2 and higher according to the POP quantification system, and 30 postmenopausal women without POP. Immunohistochemical analyses of the uterosacral ligament specimens obtained after hysterectomy were performed to determine CD44, TGF-β, MMP-2, and MMP-9 expression. The expression was quantified using ImageJ software, and the association between prolapse occurrence and risk factors was evaluated using Spearman's correlation analysis. CD44 expressions were significantly lower (p &lt; 0.05), whereas MMP-2 and MMP-9 expression was higher (p &lt; 0.0001 and p &lt; 0.05, respectively), in the POP group than in the control group. The expression of TGF-β was similar in both groups. The occurrence of uterine prolapse was positively correlated with age, postmenopausal age, and MMP-2 and MMP-9 expression (p &lt; 0.01) and negatively correlated with CD44 expression (p &lt; 0.05).ConclusionCD44, MMP-2, and MMP-9 may play critical roles in the pathogenesis of POP and may be candidate biomarkers of POP progression.
Comparison of the effects of autologous and allogeneic purified platelet-rich plasma on cartilage damage in a rabbit model of knee osteoarthritis
Authors: Wang Lingling , Zhao Luting , Shen Lianwei , Fang Qilin , Yang Zhenglei , Wang Rongrong , Wu Qing , Xie Yulei 
Published: July 2022

BackgroundPurified platelet-rich plasma (P-PRP) is gradually being used in the treatment of osteoarthritis (OA), and its sources are mainly divided into autologous and allogeneic blood. However, it is unclear whether autologous PRP is more effective or allogeneic PRP is superior.ObjectiveIn this study, autologous and allogeneic P-PRP was injected at early stage of KOA in rabbits, and then the differences in the efficacy of the two P-PRPs against KOA were compared from several perspectives, including pathological histology and immunohistochemistry.MethodExperimental rabbits were divided into normal group (n = 8), model group (n = 8), autologous P-PRP group (n = 8), and allogeneic P-PRP group (n = 8) using a random number table method. The normal and model groups did not receive any treatment, and the autologous P-PRP and allogeneic P-PRP groups received intra-articular injections of autologous and allogeneic P-PRP, respectively, to observe the changes in the gross specimens of the knee joints of the experimental rabbits in each group. The histopathological changes of chondrocytes were also observed by HE-stained sections of articular cartilage, and the expression of chondrocytes Bone morphogenetic protein-2 (BMP-2) and Sox9 were detected by immunohistochemistry.ResultsCompared with the allogeneic P-PRP group, the differences were statistically significant (P &lt; 0.05) in the gross specimens and pathological histological findings in the autologous PRP group. Immunohistochemical results showed that the expression of BMP-2 and Sox9 was elevated in both the autologous P-PRP group and the allogeneic P-PRP group compared with the model group, and the expression of BMP-2 was higher in the autologous P-PRP group than in the allogeneic P-PRP group, with a statistically significant difference (P &lt; 0.05), while there was no difference in the expression of Sox9 between the two groups (P &gt; 0.05).ConclusionIntra-articular injection of autologous P-PRP activated the expression of BMP-2 and Sox9 in chondrocytes and effectively improved KOA cartilage repair and reduced bone redundancy and joint fluid formation, and its efficacy was superior to that of intra-articular injection of allogeneic P-PRP.
Trust Deficit in Surgical Systems in an Urban Slum in India Under Universal Health Coverage: A Mixed Method Study
Authors: Vora Kranti , Saiyed Shahin , Mavalankar Dileep , Baines Lyndsay S. , Jindal Rahul M. 
Published: July 2022

Objectives: We carried out a mixed method study to understand why patients did not avail of surgical care in an urban slum in India.Methods: In our earlier study, we found that out of 10,330 people, 3.46% needed surgery; 42% did not avail of surgery (unmet needs). We conducted a follow-up study to understand reasons for not availing surgery, 141 in met needs, 91 in unmet needs. We administered 2 instruments, 16 in-depth interviews and 1 focused group discussion.Results: Responses from the 2 groups for “the Socio-culturally Competent Trust in Physician Scale for a Developing Country Setting” scale did not have significant difference except for, prescription of medicines, patients with unmet needs were less likely to agree (p = 0.076). Results between 2 groups regarding “Patient perceptions of quality” did not show significant difference except for doctors answering questions where a higher proportion of unmet need group agreed (p = 0.064). Similar observations were made in the in depth interviews and focus group.Conclusion: There is a need for understanding trust issues with health service delivery related to surgical care for marginalized populations.