bluuebunny/crossref_metadata_2025_split huggingface dataset:
The long‐term effect of dupilumab on chronic hand eczema in patients with moderate to severe atopic dermatitis—52 week results from the Dutch BioDay Registry
Authors: Voorberg Angelique N. , Romeijn Geertruida L. E. , de Bruin‐Weller Marjolein S. , Schuttelaar Marie L. A. 
Published: March 2022

AbstractBackgroundThe hands are a common predilection site of atopic dermatitis (AD). Dupilumab is licensed for the treatment of AD but not for chronic hand eczema (CHE), while CHE is challenging to treat.ObjectivesTo evaluate the long‐term effect of dupilumab on hand eczema (HE) in patients with AD from the BioDay Registry.MethodsA prospective observational study of adult patients with HE, treated for AD with dupilumab. Patients with a HE severity of at least moderate at baseline were considered for analysis. Patients with other concomitantly systemic immunosuppressive treatments were excluded. Clinical effectiveness on HE severity, using the Hand Eczema Severity Index (HECSI) and photographic guide, and health‐related quality of life, using the Quality of Life in Hand Eczema Questionnaire (QOLHEQ), were evaluated.ResultsA total of 72 patients were included. HECSI‐75 was achieved by 54/62 patients (87.1%) and HECSI‐90 by 39/72 (62.9%) at 52 weeks. Based on the photographic guide, 56/62 patients (90.3%) achieved the endpoint of ‘clear’ or ‘almost clear’. Mean QOLHEQ reduction was −63.5% (95% confidence interval −38.23 to −27.41). There was no difference in response between HE subtypes.ConclusionsThe results from this study hold promise for dupilumab to be a suitable treatment option for isolated CHE.
Does machine perfusion improve immediate and short‐term outcomes by enhancing graft function and recipient recovery after liver transplantation? A systematic review of the literature, meta‐analysis and expert panel recommendations
Authors: Ramírez‐Del Val Alejandro , Guarrera James , Porte Robert J. , Selzner Markus , Spiro Michael , Raptis Dimitri Aristotle , Friend Peter J. , Nasralla David ,   the ERAS4OLT.org Working Group
Published: March 2022

AbstractBackgroundRecent evidence supports the use of machine perfusion technologies (MP) for marginal liver grafts. Their effect on enhanced recovery, however, remains uncertain.ObjectivesTo identify areas in which MP might contribute to an ERAS program and to provide expert panel recommendations.Data sourcesOvid MEDLINE, Embase, Scopus, Google Scholar, and Cochrane Central.MethodsSystematic review and meta‐analysis following PRISMA guidelines and recommendations using the GRADE approach. CRD42021237713ResultsBoth hypothermic (HMP) and normothermic (NMP) machine perfusion demonstrated significant benefits in preventing postreperfusion syndrome (PRS) (HMP OR .33, .15‐.75 CI; NMP OR .51, .29‐.90 CI) and early allograft dysfunction (EAD) (HMP OR .51, .35‐.75 CI; NMP OR .66, .45‐.97 CI), while shortening LOS (HMP MD ‐3.9; NMP MD ‐12.41). Only NMP showed a significant decrease in the length of ICU stay (L‐ICU) (MD ‐7.07, ‐8.76; ‐5.38 CI), while only HMP diminishes the likelihood of major complications. Normothermic regional perfusion (NRP) reduces EAD (OR .52, .38–.70 CI) and primary nonfunction (PNF) (OR .51, .27‐.98 CI) without effect on L‐ICU and LOS.ConclusionsThe use of HMP decreases PRS and EAD, specifically for marginal grafts. This is supported by a shorter LOS and a lower rate of major postoperative complications (QOE; moderate | Recommendation; Strong). NMP reduces the incidence of PRS and EAD with associated shortening in L‐ICU for both DBD and DCD grafts (QOE; moderate | Recommendation; High) This technology also shortens the length of hospital stay (QOE; low | Recommendation; Strong). NRP decreases the likelihood of EAD (QOE; moderate) and the risk of PNF (QOE; low) when compared to both DBD and SRR‐DCD grafts preserved in SCS. (Recommendation; Strong).
Prolapsing giant right atrial myxoma in a young male presenting as pulmonary embolism
Authors: Singh Bhupinder , Gupta Rajiv Kumar , Tandon Rohit , Soni Ankita , Kaur Harpreet , Mohan Bishav , Wander Gurpreet S. 
Published: March 2022

AbstractA 22‐year male presented with complaints of dyspnea. Multimodality imaging revealed a polypoidal right atrial mass with submassive pulmonary embolism. The patient underwent urgent surgery. The pathological examination confirmed it as cardiac myxoma. Cardiac myxoma, a most common primary cardiac tumor, is commonly found in the left atrium. The right atrium is an uncommon site and the usual mode of presentation is the tumor or thrombus embolization to the pulmonary circulation.
Interbank contagion risk in China under an ABM approach for network formation
Authors: Lin Shiqiang , Zhang Hairui 
Published: March 2022

AbstractThis paper uses an agent‐based model to construct an interbank network for the Chinese interbank market using a sample of 299 commercial banks from 2014 to 2019. We analyze the importance and vulnerability of banks using the DebtRank algorithm. Our results show that the Chinese interbank market bears a certain level of systemic risk, especially among lower‐tiered banks. The results also show a bank is more vulnerable if it has a higher interbank lending ratio and greater financial connectivity. Meanwhile, a bank is more influential if it has a larger net worth and greater financial connectivity.
Oceanic water temperatures less than 20°C may largely adjust for underestimation of European elver otolith ages
Authors: Jessop Brian M. 
Published: March 2022

AbstractEuropean eel Anguilla anguilla otolith‐based elver ages may be substantially adjusted higher by migratory path oceanic water temperatures. Water temperatures <20°C increased temperature‐adjusted otolith ages of Japanese glass eels and elvers. Migration periods to the northern Vilaine and Severn Rivers were estimated at 785 days (2.15 years) and 781 days (2.14 years), respectively, and 958 days (2.62 years) for the southern Rio Minho, assuming a mean spawning date of 9 February (66 days shorter with a mean spawning date of 16 April). For a 9 February mean spawning date, temperature‐corrected otolith ages were higher than otolith ages by 34.4–92.7%. Higher migration route water temperatures reduced the temperature‐adjustment of otolith ages. Another approach to the temperature‐correction of otolith ages underestimated by 5.6–28.1% the migration period (days) to the southern Rio Minho and overestimated by 12.4–13.4% that to the two northern rivers. The effect of recent higher North Atlantic water temperatures on otolith daily growth increments remains to be learned. The difference between temperature‐adjusted otolith and observed ages differed little between earlier and later mean spawning dates. Otolith ages for glass and elver European eels should not be used if unadjusted for migration route water temperatures and used cautiously after adjustment for low oceanic, estuarine, and perhaps freshwater temperatures; even then otolith ageing issues remain. A greater understanding of oceanic migratory paths and durations is needed for European eels.
Food versus wildlife: Will biodiversity hotspots benefit from healthier diets?
Authors: Rasche Livia , Habel Jan C. , Stork Nigel , Schmid Erwin , Schneider Uwe A. 
Published: March 2022

AbstractAimsTerrestrial biodiversity is threatened by land use change. Modelling suggests that the remaining, potentially arable areas of natural intact vegetation (rNIV) of 9 of 35 global biodiversity hotspots may be converted to agriculture by 2050, committing their endemic species to extinction. Studies have shown that if the global population adopted a healthy, mostly plant based diet, agricultural area expansion can be reduced. We want to examine to what degree this applies to the regions covered by biodiversity hotspots.LocationGlobal.Time period2020–2050.Major taxa studiedNo particular taxa.MethodsFor every biodiversity hotspot, we simulate climate change impacts on agricultural productivity, and estimate food demand shifts from 2010 to 2050 by processing population and income growth projections. We quantify the net change in rNIV by 2050 in all hotspots by calculating the agricultural area necessary to meet the food demand under a business as usual, a healthy diet, a healthy diet plus agricultural intensification, and a healthy diet plus agricultural intensification plus crop change scenario.ResultsIn the healthy diet scenario, the rNIV of 16–21 hotspots can be preserved entirely, but 5–6 hotspots in less developed regions may lose all rNIV to agricultural area expansion. In these regions, a healthy diet implies an increase in consumed calories and no change in the already high share of plant‐based calories. When combined with agricultural intensification, these hotspots will still lose 7%–92% of rNIV. Only an additional change in crop mix patterns may preserve all.Main conclusionsWhile a change in dietary habits may be sufficient for preservation of rNIV in many hotspot regions, a healthy diet actually puts more pressure on rNIV in other hotspot regions. Intensifying agriculture and optimizing crop selection should be priorities in those regions to mitigate the expected loss of rNIV to agricultural expansion.
Spatial asynchrony matters more than alpha stability in stabilizing ecosystem productivity in a large temperate forest region
Authors: Qiao Xuetao , Geng Yan , Zhang Chunyu , Han Zhuoxiu , Zhang Zhonghui , Zhao Xiuhai , von Gadow Klaus 
Published: March 2022

AbstractAimUnderstanding the biodiversity–stability relationship has become a central issue in ecology and conservation biology. Although the stabilizing effects of tree species diversity on ecosystem productivity are well recorded in small local communities, they remain poorly understood across scales (from local to larger spatial scales). This study evaluates biodiversity–stability effects from local to larger spatial scales in a large temperate forest region, considering a range of environmental conditions and environmental heterogeneity.LocationNorth‐eastern China (c. 700,000 km2).Time period2005–2017.Major taxa studiedWoody plants.MethodsWe define stability as the temporal invariability of biomass productivity. Regional metacommunities representing larger spatial scales were developed by aggregating multiple sets of local field plots. Simple regression analysis was used to test biodiversity–stability relationships in metacommunities. Piecewise structural equation modelling was then used to disentangle the effects of diversity and abiotic variables on forest stability at local and larger spatial scales. Multiple mixed‐effects regression models were used to determine the relative contribution of individual predictive variables to stability across spatial scales.ResultsWe found that local diversity (alpha diversity) was positively related to the stability of local communities (alpha stability), whereas species turnover across space (beta diversity) was positively related to asynchronous dynamics among local communities (spatial asynchrony), regardless of whether abiotic factors were considered or not. We also found that environmental conditions and environmental heterogeneity affected forest stability across scales. The effect of spatial asynchrony on gamma stability was greater than that of alpha stability.Main conclusionsOur results imply that spatial asynchrony is a key to maintaining the stability of ecosystem productivity within a large temperate forest region. We suggest that diverse forests and heterogeneous landscapes should be sustained at multiple spatial scales to buffer the negative effects of climate change and forest degradation.
Laboratory coagulation tests and recombinant porcine factor VIII: A United Kingdom Haemophilia Centre Doctors’ Organisation guideline
Authors: Bowyer Annette , Gray Elaine , Lowe Anna , Murphy Paul , Platton Sean , Riddell Anne , Chowdary Pratima , Lester Will , Jenkins Peter Vincent 
Published: March 2022

AbstractIntroductionAcquired haemophilia A (AHA) is a rare bleeding disorder caused by development of auto‐antibodies to endogenous coagulation factor VIII (FVIII). Recombinant porcine factor VIII (rpFVIII) is currently licensed only for the management of bleeding in patients with AHA. Regular monitoring of rpFVIII is recommended to assess treatment effectiveness.AimThis guideline from the United Kingdom Haemophilia Centre Doctors’ Organisation (UKHCDO) examines the current publications in the area and aims to offer advice for the laboratory monitoring of rpFVIII in patients with AHA.MethodsA review of the current literature was undertaken followed by critical review by the authors.Results/conclusionsA validated one‐stage clotting FVIII assay is recommended for the measurement and regular monitoring of rpFVIII. Assessment of cross‐reacting rpFVIII inhibitors by one‐stage porcine Bethesda assay should be performed as part of the initial diagnosis of AHA or prior to treatment with rpFVIII. Available data show that chromogenic FVIII assays underestimate rpFVIII and this should be considered if measurement of rpFVIII is required in patients receiving Emicizumab.
Protocol for a mixed methods process evaluation of the Promoting Resilience in Nurses (PRiN) trial
Authors: Bui Minh Viet , McInnes Elizabeth , Ennis Gary , Foster Kim 
Published: March 2022

AbstractMental health nurses are exposed frequently to occupational stress and can experience a range of negative impacts on their well‐being and intention to stay in the nursing workforce. Promoting Resilience in Nurses (PRiN) is a strength‐based resilience education programme that incorporates evidence‐based cognitive behavioural and interpersonal approaches with post‐traumatic growth theory. A partially clustered randomized controlled trial at a large public mental health service will be used to examine the effects of PRiN on mental health nurses’ coping self‐efficacy, resilience, well‐being, mental health, emotional regulation, post‐traumatic growth, workplace belonging, and turnover intention as compared to controls. Process evaluations are increasingly used to help understand and interpret trial results for complex interventions. This paper describes the protocol for an embedded mixed methods process evaluation that aims to evaluate the PRiN programme implementation and identify factors that may explain variation in participant outcomes in the trial. Data collection includes a programme participant satisfaction survey; a follow‐up semi‐structured interview with selected programme participants; a unit/team manager survey on barriers and facilitators to staff recruitment and programme participation; and a fidelity checklist completed by programme facilitators. Normalisation Process Theory will be used to inform data analysis and integration. The findings will provide insights into factors that affect programme implementation, particularly in the context of the COVID‐19 pandemic and may help explain differences in participant outcomes. Findings will also inform post‐trial programme sustainability as well as potential future upscale and adaptation for implementation across healthcare settings.
Neutrosophic cubic Maclaurin symmetric mean aggregation operators with applications in multi‐criteria decision‐making
Authors: Yang Yu , Fu Yelin , Han Biao 
Published: March 2022

AbstractThe Maclaurin symmetric mean (MSM(m)) operator refers to a classical mean type of aggregation operator fusing information. The prominent property exhibited by the MSM(m) operator is to capture the interrelationship among multiple arguments. In this study, a wide range of MSM(m) operators are extended (e.g., the MSM(m), the generalized MSM(m), and the generalized geometric MSM(m)) to the neutrosophic cubic fuzzy environment, that is, the neutrosophic cubic MSM(m) operator (NCMSM(m)), the neutrosophic cubic generalized MSM (m) operator (), as well as the neutrosophic cubic geometric MSM(m) operator (). Subsequently, given the significance of the criteria, the weighted neutrosophic cubic MSM(m) operator, the weighted , and the weighted are defined over the neutrosophic cubic sets. An in‐depth investigation is conducted on several desirable properties and special cases of the mentioned operators as well as the relationship between the parameters on NCMSM(m) operator and its aggregating result. Moreover, a novel multi‐criteria decision‐making approach is developed by complying with the defined aggregation operators. Last, a numerical example and a comparative analysis, as well as sensitive analyses, are presented to verify the effectiveness of the proposed approaches and the robustness of the output result.
Crystal‐chemical investigation of the “cubic Al–Si spinel” issued from the thermal transformation of kaolinite and halloysite
Authors: Chauffeton Christelle , Wallez Gilles 
Published: March 2022

AbstractSince its discovery in 1959 as a transient nanocrystalline product of the thermal transformation of aluminum‐rich clays, the so‐called Al–Si spinel has been the object of numerous studies aimed at determining its composition. In this work, samples obtained from fired kaolinite‐ and halloysite‐containing clays were analyzed using X‐ray diffraction, leading to conclude in a single cubic (space group Fd‐3m) form, with an unvarying size of crystallites of 5 nm and a constant cell volume, typical of a transition alumina form. Trial‐and‐error Rietveld fitting procedure revealed a crystal structure consisting in an oxygen close packing and a disordered cation sublattice that differs from the known forms of spinel alumina. Rietveld quantitative phase analysis based on this model was successfully implemented on a series of fired halloysite clays, giving a first quantitative insight on the transformations in the 980–1260°C range.
In‐depth understanding the hydration process of Mn‐containing ferrite: A comparison with ferrite
Authors: Zhong Haoxuan , Zhang Kechang , Yang Lu , Wang Fazhou , Hu Shuguang , Lv Minwang , He Jianhui 
Published: March 2022

AbstractManganese (Mn) is inevitably incorporated into cement from raw materials, and is mainly incorporated into the ferrite phase of cement. In this paper, the hydration kinetic was investigated for Mn‐containing ferrite and unmodified ferrite. The evolution of the solid phases, aqueous species, and both conductivity and pH were investigated for unmodified ferrite and Mn‐containing ferrite by a diluted suspension experiment. Isothermal calorimetry, transmission electron microscopy, and mechanical property measurements were conducted to explore the influence of Mn on the hydraulic activity of ferrite. The results showed that the incorporation of Mn enhances the hydraulic activity, alleviates the influence of gypsum on the retardation of ferrite, and improves the early strength in the presence of gypsum. Mn‐containing ferrite also accelerates dissolution, influencing the initial sulfate adsorption. Mn ions eventually incorporate into (Al, Fe)‐AFt and (Al, Fe)‐AFm. During the first several hours of hydration of ferrite, there is no sulfate consumption after the initial adsorption, accompanied by a decrease of Ca2+ and Al3+ concentration. And an “adsorption‐barrier” hypothesis is proposed to explain the dormant period of sulfate consumption.
Assessing cross-laboratory performance for quantifying coliphage using EPA Method 1642
Authors: Zimmer-Faust Amity G. , Griffith John F. , Steele Joshua A. , Asato Laralyn , Chiem Tania , Choi Samuel , Diaz Arturo , Guzman Joe , Padilla Michele , Quach-Cu Jennipher , Ruiz Victor , Santos Bryan , Woo Mary , Weisberg Stephen B. 
Published: March 2022

Abstract

Aims
Widespread adoption of the new U.S. Environmental Protection Agency (USEPA) Method 1642 for enumeration of coliphage in recreational water requires demonstration that laboratories consistently meet internal method performance goals and yield results that are consistent across laboratories.

Methods and Results
Here we assess the performance of six laboratories processing a series of blind wastewater- and coliphage-spiked samples along with laboratory blanks. All laboratories met the method-defined recovery requirements when performance was averaged across samples, with the few failures on individual samples mostly occurring for less-experienced laboratories on the initial samples processed. Failures that occurred on later samples were generally attributed to easily correctable activities. Failure rates were higher for somatic vs. F+ coliphage, attributable to the more stringent performance criteria associated with somatic coliphage. There was no difference in failure rate between samples prepared in a marine water matrix compared to that in phosphate-buffered saline.

Conclusions
Variation among laboratories was similar to that previously reported for enterococci, the current bacterial indicator used for evaluating beach water quality for public health protection.

Significance and Impact of the Study
These findings suggest that laboratory performance is not an inhibitor to the adoption of coliphage as a new indicator for assessing recreational health risk.
Efficacy of EPA-registered disinfectants against two human norovirus surrogates and Clostridioides difficile endospores
Authors: Huang Jinge , Park Geun Woo , Jones Rachael M. , Fraser Angela M. , Vinjé Jan , Jiang Xiuping 
Published: March 2022

Abstract

Aims
To determine the efficacy of a panel of nine EPA-registered disinfectants against two human norovirus (HuNoV) surrogates (feline calicivirus [FCV] and Tulane virus [TuV]) and Clostridioides difficile endospores.

Methods and Results
Nine EPA-registered products, five of which contained H2O2 as active ingredient, were tested against infectious FCV, TuV and C. difficile endospores using two ASTM methods, a suspension and carrier test. Efficacy claims against FCV were confirmed for 8 of 9 products. The most efficacious product containing H2O2 as ingredient achieved a &gt;5.1 log reduction of FCV and &gt;3.1 log reduction of TuV after 5 min, and &gt;6.0 log reduction of C. difficile endospores after 10 min. Of the five products containing H2O2, no strong correlation (R2 = 0.25, p = 0.03) was observed between disinfection efficacy and H2O2 concentration. Addition of 0.025% ferrous sulphate to 1% H2O2 solution improved efficacy against FCV, TuV and C. difficile.

Conclusion
Disinfectants containing H2O2 are the most efficacious disinfection products against FCV, TuV and C. difficile endospores. Product formulation, rather than the concentration of H2O2 in a product, impacts the efficacy of a disinfection product.

Significance and Impact of Study
H2O2-based disinfectants are efficacious against surrogate viruses for HuNoV and C. difficile endospores.