bluuebunny/crossref_metadata_2025_split huggingface dataset:
Einleitung
Authors: Lünich Marco 
Published: January 2022

ZusammenfassungDer Vorgang, bei dem digitale Daten im Zuge der Computerisierung entstehen, gespeichert und manuell oder automatisch ausgewertet werden, entzieht sich der unmittelbaren und vollständigen Beobachtbarkeit durch den Menschen. Es mag zwar in gewissem Grad ein Bewusstsein über vermeintliche Konsequenzen oder Resultate geben, wenn digitale Daten entstehen, gespeichert oder ausgewertet werden. Man kann jedoch nicht vollumfänglich und oft nur mit großer Mühe im Ansatz nachvollziehen, wie Mechanismen der mittlerweile weltumspannenden Datenentstehung und -verwertung ablaufen und permanent produzierte Ergebnisse zustande kommen.
Triality and the consistent reductions on AdS3 × S3
Authors: Eloy Camille , Larios Gabriel , Samtleben Henning 
Published: January 2022

Abstract
We study compactifications on AdS3×S3 and deformations thereof. We exploit the triality symmetry of the underlying duality group SO(4,4) of three-dimensional supergravity in order to construct and relate new consistent truncations. For non-chiral D = 6, $$ \mathcal{N} $$
N
6d = (1, 1) supergravity, we find two different consistent truncations to three-dimensional supergravity, retaining different subsets of Kaluza-Klein modes, thereby offering access to different subsectors of the full nonlinear dynamics. As an application, we construct a two-parameter family of AdS3 × M3 backgrounds on squashed spheres preserving U(1)2 isometries. For generic value of the parameters, these solutions break all supersymmetries, yet they remain perturbatively stable within a non-vanishing region in parameter space. They also contain a one-parameter family of $$ \mathcal{N} $$
N
= (0, 4) supersymmetric AdS3 × M3 backgrounds on squashed spheres with U(2) isometries. Using techniques from exceptional field theory, we determine the full Kaluza-Klein spectrum around these backgrounds.
Schädelbasismetastasen mit Hirnnervenaffektionen
Authors: Hoppe J. , Kalckreuth T. , Metelmann M. , Rumpf J. J. , Klagges S. , Dietzsch S. , Scherlach C. , Kuhnt T. , Kortmann R. D. , Seidel C. 
Published: January 2022

Zusammenfassung
Hintergrund und Ziele
Schädelbasismetastasen sind eine seltene Manifestation onkologischer Erkrankungen. Wenn Hirnnerven beteiligt sind, können schon kleine Läsionen erhebliche funktionelle Beeinträchtigungen hervorrufen. Spezifische klinische Charakteristika wie neurologische Symptome, assoziierte Primärtumoren, Prognose und optimale Therapie der Erkrankung sind schlecht definiert und sollen in dieser Arbeit systematisch dargestellt werden.

Methoden
Mit einem monozentrischen retrospektiven Ansatz wurden Schädelbasismetastasen bei Patienten, die im Zeitraum von 2006 bis 2018 behandelt wurden, detailliert hinsichtlich klinischer Charakteristika, der durchgeführten Therapie und des weiteren Erkrankungsverlaufs analysiert.

Ergebnisse
Insgesamt 45 Patienten mit Schädelbasismetastasen und Hirnnervenausfällen wurden erfasst. Die häufigsten Primärtumoren waren Prostatakarzinom (27 %), Mammakarzinom (22 %) und multiples Myelom (16 %). Die am häufigsten betroffenen Hirnnerven waren Nervus trigeminus (42 %), Nervus oculomotorius (33 %) und Nervus facialis (27 %). 84 % aller Patienten wiesen außerhalb der Schädelbasis liegende weitere Knochenmetastasen auf. Eine durale Infiltration oder eine Meningeosis neoplastica lagen bei je 13 % der Patienten vor. Nach Bestrahlung waren 61 % der Patienten hinsichtlich der auf die Schädelbasismetastase zurückzuführenden Symptome klinisch stabil, bei 22 % hatten sich die Symptome gebessert. Das mediane Gesamtüberleben betrug 8 Monate (Spanne: 0,4–51 Monate). Bei Patienten, die mit einer dosiseskalierten Bestrahlung behandelt wurden, bestand eine längere Überlebenszeit (16,4 Monate vs. 4,7 Monate). Dieser Effekt persistierte auch in der multivariaten Analyse unter Berücksichtigung der Faktoren Karnofsky-Index, Metastasenanzahl, Primärtumor und Bestrahlungsdosis (HR 0,37, p = 0,02).

Diskussion
Schädelbasismetastasen mit Hirnnervenausfällen haben ein vielgestaltiges Bild und oft eine schlechte Prognose. Um potenziell eine Überlebenszeitverbesserung zu erreichen, sind präzise Diagnostik und Therapie Voraussetzung. Prospektive kontrollierte Untersuchungen sind notwendig.
On two mod p period maps: Ekedahl–Oort and fine Deligne–Lusztig stratifications
Authors: Andreatta Fabrizio 
Published: January 2022

AbstractConsider a Shimura variety of Hodge type admitting a smooth integral model S at an odd prime $$p\ge 5$$

p
≥
5

. Consider its perfectoid cover $$S^{\text {ad}}(p^\infty )$$

S
ad

(

p
∞

)

and the Hodge–Tate period map introduced by Caraiani and Scholze. We compare the pull-back to $$S^{\text {ad}}(p^\infty )$$

S
ad

(

p
∞

)

of the Ekedahl–Oort stratification on the mod p special fiber of a toroidal compactification of S and the pull back to $$S^\text {ad}(p^\infty )$$

S
ad

(

p
∞

)

of the fine Deligne–Lusztig stratification on the mod p special fiber of the flag variety which is the target of the Hodge–Tate period map. An application to the non-emptiness of Ekedhal–Oort strata is provided.
A biomimetic enzyme-linked immunosorbent assay (BELISA) for the analysis of gonadorelin by using molecularly imprinted polymer-coated microplates
Authors: Torrini Francesca , Caponi Laura , Bertolini Andrea , Palladino Pasquale , Cipolli Francesca , Saba Alessandro , Paolicchi Aldo , Scarano Simona , Minunni Maria 
Published: January 2022

AbstractAn original biomimetic enzyme-linked immunoassay (BELISA) to target the small peptide hormone gonadorelin is presented. This peptide has been recently listed among the substances banned in sports by the World Antidoping Agency (WADA) since its misuse by male athletes triggers testosterone increase. Hence, in response to this emerging issue in anti-doping controls, we proposed BELISA which involves the growth of a polynorepinephrine (PNE)–based molecularly imprinted polymer (MIP) directly on microwells. PNE, a polydopamine (PDA) analog, has recently displayed impressive performances when it was exploited for MIP preparation, giving even better results than PDA. Gonadorelin quantification was accomplished via a colorimetric indirect competitive bioassay involving the competition between biotinylated gonadorelin linked to the signal reporter and the unlabeled analyte. These compete for the same MIP binding sites resulting in an inverse correlation between gonadorelin concentration and the output color signal (λ = 450 nm). A detection limit of 277 pmol L−1 was achieved with very good reproducibility in standard solutions (avCV% = 4.07%) and in urine samples (avCV% = 5.24%). The selectivity of the assay resulted adequate for biological specimens and non-specific control peptides. In addition, the analytical figures of merit were successfully validated by mass spectrometry, the reference anti-doping benchtop platform for the analyte. BELISA was aimed to open real perspectives for PNE-based MIPs as alternatives to antibodies, especially when the target analyte is a poorly or non-immunogenic small molecule, such as gonadorelin.
Graphical abstract
Treatment with Soluble Activin Type IIB Receptor Ameliorates Ovariectomy-Induced Bone Loss and Fat Gain in Mice
Authors: Puolakkainen Tero , Rummukainen Petri , Pihala-Nieminen Vappu , Ritvos Olli , Savontaus Eriika , Kiviranta Riku 
Published: January 2022

Abstract
Introduction
In postmenopausal osteoporosis, hormonal changes lead to increased bone turnover and metabolic alterations including increased fat mass and insulin resistance. Activin type IIB receptors bind several growth factors of the TGF-β superfamily and have been demonstrated to increase muscle and bone mass. We hypothesized that ActRIIB-Fc treatment could improve bone and muscle mass, inhibit fat accumulation, and restore metabolic alterations in an ovariectomy (OVX) model of postmenopausal osteoporosis.

Materials and Methods
Female C57Bl/6 N mice were subjected to SHAM or OVX procedures and received intraperitoneal injections of either PBS or ActRIIB-Fc (5 mg/kg) once weekly for 7 weeks. Glucose and insulin tolerance tests (GTT and ITT, respectively) were performed at 7 and 8 weeks, respectively. Bone samples were analyzed with micro-computed tomography imaging, histomorphometry, and quantitative RT-PCR.

Results
Bone mass decreased in OVX PBS mice compared to the SHAM PBS group but ActRIIB-Fc was able to prevent these changes as shown by µCT and histological analyses. This was due to decreased osteoclast numbers and function demonstrated by histomorphometric and qRT-PCR analyses. OVX induced adipocyte hypertrophy that was rescued by ActRIIB-Fc, which also decreased systemic adipose tissue accumulation. OVX itself did not affect glucose levels in GTT but ActRIIB-Fc treatment resulted in impaired glucose clearance in both SHAM and OVX groups. OVX induced mild insulin resistance in ITT but ActRIIB-Fc treatment did not affect this.

Conclusion
Our results reinforce the potency of ActRIIB-Fc as a bone-enhancing agent but also bring new insight into the metabolic effects of ActRIIB-Fc in normal and OVX mice.
Drug utilisation in neonatal units in England and Wales: a national cohort study
Authors: Al-Turkait Asma , Szatkowski Lisa , Choonara Imti , Ojha Shalini 
Published: January 2022

Abstract
Purpose
To describe drug utilisation patterns in neonatal units.

Methods
Retrospective observational cohort study using data held in the National Neonatal Research Database (NNRD) for neonatal units in England and Wales including infants born at 23 to 44 weeks’ gestational age (GA) from 01 January 2010 to 31 December 2017.

Results
The cohort included 17,501 (3%) extremely preterm infants; 40,607 (7%) very preterm infants; 193,536 (31%) moderate-to-late preterm infants; and 371,606 (59%) term infants. The number of unique drugs received by an infant (median (IQR)) increased with decreasing GA: 17 (11–24) in extremely preterm, 7 (5–11) in very preterm, 3 (0–4) in moderate-to-late preterm, and 3 (0–3) in term infants. The two most frequently prescribed drugs were benzylpenicillin and gentamicin in all GA groups, and caffeine in extremely preterm. Other frequently used drugs among preterm infants were electrolytes, diuretics and anti-reflux medications. Among infants <32 weeks’ GA, the largest increase in use was for surfactant (given on the neonatal unit), caffeine and probiotics, while domperidone and ranitidine had the largest decline.

Conclusion
Antibiotics, for all GAs and caffeine, among preterm infants, are the most frequently used drugs in neonatal medicine. Preterm infants are exposed to a high burden of drugs, particularly antibiotics. Changing patterns in use reflect the emergence of evidence in some areas but several non-evidence-based drugs continue to be used widely. Improvements are needed to ensure rational drug use on neonatal units.

Registration
ClinicalTrials.gov (NCT03773289). Date of registration 21 Dec 2018.
Diagnosis of ulnar nerve entrapment anterior to the medial epicondyle by ultrasound elastography and diffusion tensor imaging with fiber tractography: a case report
Authors: Jaques Guillaume , Becce Fabio , Ledoux Jean-Baptiste , Durand Sébastien 
Published: January 2022

AbstractUlnar/cubital tunnel syndrome is the second most common compressive neuropathy of the upper limb. Permanent location of the ulnar nerve anterior to the medial epicondyle is extremely rare, with only five cases reported in the literature. Using ultrasound elastography and diffusion tensor imaging with fiber tractography, we diagnosed a case in which ulnar nerve entrapment was associated with anterior nerve location. Surgical release confirmed the diagnosis and the patient was symptom free 3 months after surgery.
Elective laparoscopic cholecystectomy: recurrent biliary admissions predispose to difficult cholecystectomy
Authors: Lucocq James , Scollay John , Patil Pradeep 
Published: January 2022

Abstract
Introduction
Patients undergoing elective laparoscopic cholecystectomy (ELLC) represent a heterogeneous group making it challenging to stratify risk. The aim of this paper is to identify pre-operative factors associated with adverse peri- and post-operative outcomes in patients undergoing ELLC. This knowledge will help stratify risk, guide surgical decision making and better inform the consent process.

Methods
All patients who underwent ELLC between January 2015 and December 2019 were included in the study. Pre-operative data and both peri- and post-operative outcomes were collected retrospectively from multiple databases using a deterministic records-linkage methodology. Patients were divided into groups based on clinical indication (i.e. biliary colic versus cholecystitis) and adverse outcomes were compared. Multivariate regression models were generated for each adverse outcome using pre-operative independent variables.

Results
Two-thousand one hundred and sixty-six ELLC were identified. Rates of peri- and post-operative adverse outcomes were significantly higher in the cholecystitis versus biliary colic group and increased with number of admissions of cholecystitis (p < 0.05). Rates of subtotal (29.5%), intra-operative complication (9.8%), post-operative complications (19.6%), prolonged post-operative stay (45.9%) and re-admission (16.4%) were significant in the group of patients with ≥ 2 admissions with cholecystitis.

Conclusion
Our data demonstrate that patients with repeated biliary admission (particularly cholecystitis) ultimately face an increased risk of a difficult ELLC with associated complications, prolonged post-operative stay and readmissions. These data provide robust evidence that individualised risk assessment and consent are necessary before ELLC. Strategies to minimise recurrent biliary admissions prior to LC should be implemented.
Laparoscopic versus robotic-assisted, left-sided colectomies: intra- and postoperative outcomes of 683 patients
Authors: Gass Jörn-Markus , Daume Diana , Schneider Romano , Steinemann Daniel , Mongelli Francesco , Scheiwiller Andreas , Fourie Lana , Kern Beatrice , von Flüe Markus , Metzger Jürg , Angehrn Fiorenzo , Bolli Martin 
Published: January 2022

AbstractBackgroundRobotic-assisted colorectal surgery has gained more and more popularity over the last years. It seems to be advantageous to laparoscopic surgery in selected situations, especially in confined regions like a narrow male pelvis in rectal surgery. Whether robotic-assisted, left-sided colectomies can serve as safe training operations for less frequent, low anterior resections for rectal cancer is still under debate. Therefore, the aim of this study was to evaluate intra- and postoperative results of robotic-assisted laparoscopy (RAL) compared to laparoscopic (LSC) surgery in left-sided colectomies.MethodsBetween June 2015 and December 2019, 683 patients undergoing minimally invasive left-sided colectomies in two Swiss, high-volume colorectal centers were included. Intra- and postoperative outcome parameters were collected and analyzed.ResultsA total of 179 patients undergoing RAL and 504 patients undergoing LSC were analyzed. Baseline characteristics showed similar results. Intraoperative complications occurred in 0.6% of RAL and 2.0% of LSC patients (p = 0.193). Differences in postoperative complications graded Dindo ≥ 3 were not statistically significant (RAL 3.9% vs. LSC 6.3%,p = 0.227). Occurrence of anastomotic leakages showed no statistically significant difference [RALn = 2 (1.1%), LSCn = 8 (1.6%),p = 0.653]. Length of hospital stay was similar in both groups. Conversions to open surgery were significantly higher in the LSC group (6.2% vs.1.7%,p = 0.018), while stoma formation was similar in both groups [RALn = 1 (0.6%), LSCn = 5 (1.0%),p = 0.594]. Operative time was longer in the RAL group (300 vs. 210.0 min,p < 0.001).ConclusionRobotic-assisted, left-sided colectomies are safe and feasible compared to laparoscopic resections. Intra- and postoperative complications are similar in both groups. Most notably, the rate of anastomotic leakages is similar. Compared to laparoscopic resections, the analyzed robotic-assisted resections have longer operative times but less conversion rates. Further prospective studies are needed to confirm the safety of robotic-assisted, left-sided colectomies as training procedures for low anterior resections.
Predicting surgical outcome in posterior retroperitoneoscopic adrenalectomy with the aid of a preoperative nomogram
Authors: van Uitert Allon , van de Wiel Elle C. J. , Ramjith Jordache , Deinum Jaap , Timmers Henri J. L. M. , Witjes J. Alfred , Kool Leo J. Schultze , Langenhuijsen Johan F. 
Published: January 2022

Abstract
Background
Posterior retroperitoneoscopic adrenalectomy (PRA) has several advantages over transperitoneal laparoscopic adrenalectomy (TLA) regarding operative time, blood loss, postoperative pain, and recovery. However, it can be a technically challenging procedure. To improve patient selection for PRA, we developed a preoperative nomogram to predict operative time.

Methods
All consecutive patients with tumors of ≤ 7 cm and a body mass index (BMI) of < 35 kg/m2 undergoing unilateral PRA between February 2011 and March 2020 were included in the study. The primary outcome was operative time as surrogate endpoint for surgical complexity. Using ten patient variables, an optimal prediction model was created, with a best subsets regression analysis to find the best one-variable up to the best seven-variable model.

Results
In total 215 patients were included, with a mean age of 52 years and mean tumor size of 2.4 cm. After best subsets regression analysis, a four-variable nomogram was selected and calibrated. This model included sex, pheochromocytoma, BMI, and perinephric fat, which were all individually significant predictors. This model showed an ideal balance between predictive power and applicability, with an R2 of 38.6.

Conclusions
A four-variable nomogram was developed to predict operative time in PRA, which can aid the surgeon to preoperatively identify suitable patients for PRA. If the nomogram predicts longer operative time and therefore a more complex operation, TLA should be considered as an alternative approach since it provides a larger working space. Also, the nomogram can be used for training purposes to select patients with favorable characteristics when learning this surgical approach.
Improving the Numerical Modelling of In-Situ Rock Bolts Using Axial and Bending Strain Data from Instrumented Bolts
Authors: Singh Prasoon , Jang Hyongdoo , Spearing A. J. S. Sam 
Published: January 2022

AbstractNumerical modelling has become an important tool in the underground rock bolt reinforcement designing process. Numerical modelling provides the advantage of easily and quickly simulating complex underground geometries and mechanisms with sensitivity analyses. However, a numerical model needs to be calibrated using mathematical solutions, lab testing or with actual in-situ observations and measurements (which is the preferred method) before its results can be quantitatively applied to reinforcement design. Instrumented rock bolts provide a useful data source for calibrating in-situ rock bolt models. In this work, procedures have been presented to identify and determine the orientation of structures in the rock mass based on the strains on the instrumented rock bolts. A method to calibrate the rock bolt model with in-situ data is also presented. The results of the presented procedures have been validated with laboratory tests and numerical modelling. The procedures have been applied to create and calibrate an in-situ rock bolt model in FLAC3D and the results are validated using in-situ data.
Correlation of retinal alterations with vascular structure of macular neovascularisation in swept-source optical coherence tomography angiography in age-related macular degeneration
Authors: Faatz Henrik , Rothaus Kai , Ziegler Martin , Book Marius , Spital Georg , Heimes-Bussmann Britta , Pauleikhoff Daniel , Lommatzsch Albrecht 
Published: January 2022

Abstract
Purpose
The aim of this study was to find out whether the vascular architecture of untreated macular neovascularisations (MNV) in neovascular age-related macular degeneration (nAMD) as visualised with optic coherence tomography angiography (OCTA) is associated with functional and known morphological alterations of the retina in optic coherence tomography (SD-OCT).

Methods
The study design was retrospective with consecutive patient inclusion. In 107 patients with newly diagnosed nAMD, MNV were detected by means of OCTA and automated quantitative vascular analysis was performed. The MNV characteristics measured were area, flow density, total vascular length (sumL), density of vascular nodes (numN), fractal dimension (FD) and average vascular width (avgW). These parameters were assessed for associations with vision (BCVA), central retinal thickness (CRT), fluid distribution, the elevation of any pigment epithelial detachment (PED), the occurrence of subretinal haemorrhage and atrophy.

Results
BCVA was significantly worse with greater MNV area and sumL. Fluid distribution differed significantly in relation to area (p < 0.005), sumL (p < 0.005) and FD (p = 0.001). Greater PED height was significantly associated with higher numN (p < 0.05) and lower avgW (p < 0.05). Atrophy was present significantly more often in MNV with larger area (p < 0.05), higher sumL (p < 0.05) and higher flow density (p = 0.002). None of the MNV parameters had a significant association with CRT or the occurrence of haemorrhage.

Conclusion
OCTA is not restricted to evaluation of secondary changes but offers the opportunity to analyse the vascular structure of MNV in detail. Differences in vascular morphology are associated with certain secondary changes in retinal morphology. There are thus grounds for optimism that further research may identify and classify OCTA-based markers to permit more individualised treatment of nAMD.
Preventive Group Training Improves Children’s Outcomes after Divorce: A Dutch Quasi-experimental Study
Authors: Klein Velderman Mariska , van Dommelen Paula , Pannebakker Fieke D. , Reijneveld Sijmen A. 
Published: January 2022

AbstractWorldwide, many children experience parental separation and divorce. This has a significant impact on their well-being, and emotional and behavioral functioning, and calls for prevention. To assess the effects of the Children of Divorce Intervention Program in the Netherlands (CODIP-NL) on 6- to 8-year-olds, we performed a quasi-experimental effect study. The study compared children receiving CODIP-NL (intervention: I, n = 104), children not receiving CODIP-NL but having divorced parents (divorced control: DC, n = 37), and children belonging to non-divorced families (non-divorced control: NDC, n = 138). Outcomes pertained to children’s positive functioning, emotional and behavioral problems, and well-being. We assessed pre- to post-test differences in change in mother-reported outcomes between the intervention and control groups, and pre- to post-test differences in group leader reports. The intervention led to increases in mother-reported positive functioning (d = 0.97 I vs. DC; d = 1.04 I vs. NDC), and well-being (d = 1.00 I vs. DC; d = 0.84 I vs. NDC). Mother-reported child emotional and behavioral problems decreased after participation (total difficulties, d = 0.73 I vs. DC; d = 0.49 I vs. NDC). Group leader-reported pre- to post-test differences (p ≤ 0.001) pointed in the same directions. Findings support further implementation of CODIP to support children’s positive functioning and well-being, and to decrease emotional and behavioral problems after their parents’ divorce.