bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMBI: Artificial Intelligence for Computer-Based Forensic Analysis of Persons
Authors: Becker Sven , Heuschkel Marie , Richter Sabine , Labudde Dirk 
Published: June 2022

AbstractDuring the prosecution process the primary objective is to prove criminal offences to the correct perpetrator to convict them with legal effect. However, in reality this may often be difficult to achieve. Suppose a suspect has been identified and is accused of a bank robbery. Due to the location of the crime, it can be assumed that there is sufficient image and video surveillance footage available, having recorded the perpetrator at the crime scene. Depending on the surveillance system used, there could be even high-resolution material available. In short, optimal conditions seem to be in place for further investigations, especially as far as the identification of the perpetrator and the collection of evidence of their participation in the crime are concerned. However, perpetrators usually act using some kind of concealment to hide their identity. In most cases, they disguise their faces and even their gait. Conventional investigation approaches and methods such as facial recognition and gait analysis then quickly reach their limits. For this reason, an approach based on anthropometric person-specific digital skeletons, so-called rigs, that is being researched by the COMBI research project is presented in this publication. Using these rigs, it should be possible to assign known identities, comparable to suspects, to unknown identities, comparable to perpetrators. The aim of the COMBI research project is to study the anthropometric pattern as a biometric identifier as well as to make it feasible for the standardised application in the taking of evidence by the police and prosecution. The approach is intended to present computer-aided opportunities for the identification of perpetrators that can support already established procedures.
Sodium Polyacrylate-Modified Bentonite and Its Dehydration Testing in Real Oil
Authors: Meng Fanyu , Shi Li , Meng Xuan , Liu Naiwang 
Published: June 2022

AbstractRemoving trace water from oil is an important industrial process and is commonly accomplished using vacuum filtration. The drawbacks of this method, however, are: poor efficiency, large oil loss, and significant energy consumption. The objective of the current study was to develop a better system to solve these problems using a sodium polyacrylate (PAA-Na)-modified bentonite as the dehydrating agent and, for the first time, to apply it to transformer oil. PAA-Na was prepared by aqueous solution polymerization. A dehydration test was carried out to determine the optimum addition of PAA-Na, and the highest dehydration rate of 76.5% was obtained with the addition of 20 wt.% PAA-Na. The steady dehydration rate of the PAA-Na-modified bentonite was better than that of other adsorbents (calcium chloride, zeolite 5A, unmodified bentonite). The process of adsorbing saturated water vapor on PAA-Na modified bentonite was studied and interpreted from the aspects of adsorption isotherms and thermodynamic properties. The results showed that the adsorption isotherm data followed the Freundlich isotherm model and the thermodynamic parameters indicated that the process was endothermic. Fourier-transform infrared spectroscopy results revealed that PAA-Na was synthesized successfully and it had a huge proportion of hydrophilic groups. According to thermogravimetric analysis, the PAA-Na-modified bentonite was stable up to 200°C, giving a flexible region for pretreatment and regeneration. X-ray diffraction showed no change in the diffraction pattern before and after modification. Moreover, considering the results of scanning electron microscopy and surface-area analyses, one may safely say that PAA-Na was distributed homogeneously on the surface of the bentonite. In addition, PAA-Na-modified bentonite exhibited a high dehydration rate in xylene, naphtha, and diesel, indicating a broad range of applications.
Homologous basic helix–loop–helix transcription factors induce distinct deformations of torsionally-stressed DNA: a potential transcription regulation mechanism
Authors: Hörberg Johanna , Moreau Kevin , Reymer Anna 
Published: June 2022

Abstract
Changing torsional restraints on DNA is essential for the regulation of transcription. Torsional stress, introduced by RNA polymerase, can propagate along chromatin facilitating topological transitions and modulating the specific binding of transcription factors (TFs) to DNA. Despite the importance, the mechanistic details on how torsional stress impacts the TFs-DNA complexation remain scarce. Herein, we address the impact of torsional stress on DNA complexation with homologous human basic helix–loop–helix (BHLH) hetero- and homodimers: MycMax, MadMax and MaxMax. The three TF dimers exhibit specificity towards the same DNA consensus sequence, the E-box response element, while regulating different transcriptional pathways. Using microseconds-long atomistic molecular dynamics simulations together with the torsional restraint that controls DNA total helical twist, we gradually over- and underwind naked and complexed DNA to a maximum of ± 5°/bp step. We observe that the binding of the BHLH dimers results in a similar increase in DNA torsional rigidity. However, under torsional stress the BHLH dimers induce distinct DNA deformations, characterised by changes in DNA grooves geometry and a significant asymmetric DNA bending. Supported by bioinformatics analyses, our data suggest that torsional stress may contribute to the execution of differential transcriptional programs of the homologous TFs by modulating their collaborative interactions.
Older people's family relationships in disequilibrium during the COVID-19 pandemic. What really matters?
Authors: Derrer-Merk Elfriede , Ferson Scott , Mannis Adam , Bentall Richard , Bennett Kate M. 
Published: June 2022

AbstractInter- and intragenerational relationships are known to be important in maintaining the wellbeing of older people. A key aspect of these relationships is the exchange of both emotional and instrumental social support. However, relatively little is known about how this exchange of support changes in the context of widespread disruption. The COVID-19 pandemic provides an opportunity to examine how older people's family relationships are impacted by such social change. The present qualitative study explores how older people in the United Kingdom experienced changes in inter- and intragenerational support during the COVID-19 pandemic. Participants (N = 33) were recruited through a large-scale nationally representative survey (https://www.sheffield.ac.uk/psychology-consortium-covid19). We asked how life had been pre-pandemic, how they experienced the first national lockdown and what the future might hold in store. The data were analysed using constructivist grounded theory. This paper focuses on the importance of family relationships and how they changed as a consequence of the pandemic. We found that the family support system had been interrupted, that there were changes in the methods of support and that feelings of belonging were challenged. We argue that families were brought into disequilibrium through changes in the exchange of inter- and intragenerational support. The important role of grandchildren for older adults was striking and challenged by the pandemic. The significance of social connectedness and support within the family had not changed during the pandemic, but it could no longer be lived in the same way. The desire to be close to family members and to support them conflicted with the risk of pandemic infection. Our study found support for the COVID-19 Social Connectivity Paradox: the need for social connectedness whilst maintaining social distance. This challenged family equilibrium, wellbeing and quality of life in older people.
Vocabulary learning from reading and listening: Replications of Brown et al. (2008) and Vidal (2011)
Authors: Serrano Raquel 
Published: June 2022

AbstractThere has been a great deal of interest in second language vocabulary studies regarding the potential of reading as a source of incidental vocabulary learning. More recently, several studies have also focused on comparing reading with other input modes, such as listening, or reading-while-listening. Among these studies there are two – Brown et al. (2008) and Vidal (2011) – that have been extensively cited because of the evidence they provided regarding the differential effects of reading versus listening in promoting incidental vocabulary gains. The present study presents different arguments for replication of these two original studies as well as specific ideas on how such replications could be conducted.
Screening and diagnostic imaging at centres performing congenital heart surgery in middle-income countries
Authors: Majeed Amara , Jenkins Kathy , Gauvreau Kimberlee , Forero Julian F. , Pérez Juárez Fabiola , Kulkarni Snehal , Minh Phuc Vu , Schidlow David 
Published: June 2022

AbstractBackground:Surgical care for CHD is increasingly available in low- and middle-income countries, and efforts to optimise outcomes are growing. This study characterises cardiac imaging and prenatal diagnosis infrastructure in this setting.Methods:An infrastructure survey was administered to sites participating in the International Quality Improvement Collaborative for CHD. Questions regarding transthoracic, transesophageal and epicardial echocardiography, cardiac CT, cardiac magnetic resonance, prenatal screening and fetal echocardiography were included. Associations with in-hospital and 30-day mortality were assessed.Results:Thirty-seven sites in 17 countries responded. Programme size and geography varied considerably: < 250 cases (n = 13), 250–500 cases (n = 9), > 500 cases (n = 15); Americas (n = 13), Asia (n = 18), and Eastern Europe (n = 6). All had access to transthoracic echo. Most reported transesophageal and epicardial echocardiography availability (86 and 89%, respectively). Most (81%) had cardiac CT, but only 54% had cardiac magnetic resonance. A third reported impediments to imaging, including lack of portable machines, age/size-appropriate equipment and advanced cardiac imaging access and training. Only 19% of centres reported universal prenatal CHD screening in their catchment area, and only 46% always performed fetal echocardiography if screening raised concern for CHD. No statistically significant associations were identified between imaging modality availability and surgical outcomes.Conclusions:Although access to echocardiography is available in most middle-income countries; advanced imaging modalities (cardiac CT and magnetic resonance) are not always accessible. Prenatal screening for CHD is low, and availability of fetal echocardiography is limited. Imaging infrastructure in low- and middle-income countries and associations with outcomes merits additional study.
A Statistical Study of Auroral Medium Frequency Bursts and Anomalous Incoherent Scatter Radar Echoes
Authors: Hudson Emily , LaBelle James , Reimer Ashton , Akbari Hassanali 
Published: June 2022

AbstractDifferent types of incoherent scatter radar (ISR) echoes are observed associated with aurora, including some which have been interpreted as signatures of cavitating Langmuir turbulence (CLT). Akbari et al. (2013) https://doi.org/10.1002/jgra.50314 discussed two instances of correlation between CLT and naturally occurring radio emissions called medium frequency burst (MFB) which occur at substorm onsets. Based on that observation, radio detections of MFB from Toolik Lake Observatory have been applied to investigate occurrence of CLT in ISR data from Poker Flat Incoherent Scatter Radar and their possible correlation with MFB. Of 131 MFB events, 25 occurred within 15 min of an ISR echo detection, compared to 6 of 116 intervals of a control set with similar local time and seasonal distribution. The difference is significant at the 10−4 level, suggesting that ISR echoes are more probable during substorm onset times identified using MFB as a proxy. However, only four observed ISR echoes coincident with one MFB event showed both specific characteristics consistent with CLT. Furthermore, investigation of the angle of arrival of MFB suggests that the electromagnetic emissions do not originate from the plasma volume where the ISR detects the echoes. The small number of coincident ISR echoes and MFB is expected due to the different volumes in which the emissions and the echoes are detected. 50% of the MFB events occurred within 20 min of a substorm onset independently identified versus 8% of the control set intervals, confirming the correlation of MFB with substorm onsets.
The World Hypertension League Science of Salt: a regularly updated systematic review of salt and health outcomes studies (Sept 2019 to Dec 2020)
Authors: Wang Nan Xin , Arcand JoAnne , Campbell Norm R. C. , Johnson Claire , Malta Daniela , Petersen Kristina , Rae Sarah , Santos Joseph Alvin , Sivakumar Bridve , Thout Sudhir Raj , McLean Rachael 
Published: June 2022

AbstractThe World Hypertension League Science of Salt health outcomes review series highlights high-quality publications relating to salt intake and health outcomes. This review uses a standardised method, outlined in previous reviews and based on methods developed by WHO, to identify and critically appraise published articles on dietary salt intake and health outcomes. We identified 41 articles published between September 2019 to December 2020. Amongst these, two studies met the pre-specified methodological quality criteria for critical appraisal. They were prospective cohort studies and examined physical performance and composite renal outcomes as health outcomes. Both found an association between increased/higher sodium intake and poorer health outcomes. Few studies meet criteria for high-quality methods. This review adds further evidence that dietary salt reduction has health benefits and strengthens evidence relating to health outcomes other than blood pressure and cardiovascular disease. We observe that most studies on dietary sodium do not have adequate methodology to reliably assess sodium intake and its association with health outcomes.
IGF1R acts as a cancer-promoting factor in the tumor microenvironment facilitating lung metastasis implantation and progression
Authors: Alfaro-Arnedo Elvira , López Icíar P. , Piñeiro-Hermida Sergio , Canalejo Marta , Gotera Carolina , Sola Jesús Javier , Roncero Alejandra , Peces-Barba Germán , Ruíz-Martínez Carlos , Pichel José G. 
Published: June 2022

AbstractGiven the long-term ineffectiveness of current therapies and late-stage diagnoses, lung cancer is a leading cause of malignant diseases. Tumor progression is influenced by cancer cell interactions with the tumor microenvironment (TME). Insulin-like growth factor 1 receptor (IGF1R) was reported to affect the TME; however, the role of IGF1R in lung TME has not been investigated. First, we assessed IGF1R genomic alterations and expression in NSCLC patient tissue samples, as well as IGF1R serum levels. Next, we performed tumor heterotopic transplantation and pulmonary metastases in IGF1R-deficient mice using melanoma and Lewis lung carcinoma (LLC) cells. Herein we report increased amplification and mRNA expression, as well as increased protein expression (IGF1R/p-IGF1R) and IGF1R levels in tumor samples and serum from NSCLC patients, respectively. Moreover, IGF1R deficiency in mice reduced tumor growth, proliferation, inflammation and vascularization, and increased apoptosis after tumor heterotopic transplantation. Following induction of lung metastasis, IGF1R-deficient lungs also demonstrated a reduced tumor burden, and decreased expression of tumor progression markers, p-IGF1R and p-ERK1/2. Additionally, IGF1R-deficient lungs showed increased apoptosis and diminished proliferation, vascularization, EMT and fibrosis, along with attenuated inflammation and immunosuppression. Accordingly, IGF1R deficiency decreased expression of p-IGF1R in blood vessels, fibroblasts, tumor-associated macrophages and FOXP3+ tumor-infiltrating lymphocytes. Our results demonstrate that IGF1R promotes metastatic tumor initiation and progression in lung TME. Furthermore, our research indicates that IGF1R could be a potential biomarker for early prediction of drug response and clinical evolution in NSCLC patients.
Atomic origin of the coexistence of high critical current density and high Tc in CuBa2Ca3Cu4O10+δ superconductors
Authors: Zhang Xuefeng , Zhao Jianfa , Zhao Huijuan , Shi Luchuan , Deng Sihao , Chen Jie , He Lunhua , Hu Zhiwei , Jin Changqing , Zhu Jing 
Published: June 2022

AbstractFor cuprate superconductors, a high critical transition temperature (Tc) can be realized in compounds containing multiple CuO2 layers in the unit cell, while a high critical current density (Jc) is rarely sustained above liquid nitrogen temperature. The CuBa2Ca3Cu4O10+δ (Cu-1234) superconductors synthesized under high oxygen pressure incredibly exhibit high Tc (~117 K) and high Jc (>104 A/cm2, 100 K) values. Here, the “double high” traits of Cu-1234 were investigated with advanced scanning transmission electron microscopy. It was revealed that ordering vacancies and plate-like 90° microdomains induced efficient microstructure pinning centers that suppressed vortex flux flow and enhanced Jc. Furthermore, metallic charge-reservoir blocks [Ba2CuO3+δ] were composed of unique compressed [CuO6] octahedra, which induced many holes with 2pz symmetry that significantly decreased the superconducting anisotropy and dramatically enhanced the interlayer coupling that guaranteed a high Jc. On the other hand, optimally doped CuO2 planes inside the thick superconducting blocks [Ca3Cu4O8] maintained a high Tc. Our results are applicable to design and synthesis of new superconductors with “double high” traits.
Evolution of sexual systems, sex chromosomes and sex-linked gene transcription in flatworms and roundworms
Authors: Wang Yifeng , Gasser Robin B. , Charlesworth Deborah , Zhou Qi 
Published: June 2022

AbstractMany species with separate male and female individuals (termed ‘gonochorism’ in animals) have sex-linked genome regions. Here, we investigate evolutionary changes when genome regions become completely sex-linked, by analyses of multiple species of flatworms (Platyhelminthes; among which schistosomes recently evolved gonochorism from ancestral hermaphroditism), and roundworms (Nematoda) which have undergone independent translocations of different autosomes. Although neither the evolution of gonochorism nor translocations fusing ancestrally autosomal regions to sex chromosomes causes inevitable loss of recombination, we document that formerly recombining regions show genomic signatures of recombination suppression in both taxa, and become strongly genetically degenerated, with a loss of most genes. Comparisons with hermaphroditic flatworm transcriptomes show masculinisation and some defeminisation in schistosome gonad gene expression. We also find evidence that evolution of sex-linkage in nematodes is accompanied by transcriptional changes and dosage compensation. Our analyses also identify sex-linked genes that could assist future research aimed at controlling some of these important parasites.
Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration
Authors: Jhanji Megha , Rao Chintada Nageswara , Massey Jacob C. , Hope Marion C. , Zhou Xueyan , Keene C. Dirk , Ma Tao , Wyatt Michael D. , Stewart Jason A. , Sajish Mathew 
Published: June 2022

AbstractSerum tyrosine levels increase during aging, neurocognitive, metabolic, and cardiovascular disorders. However, calorie restriction (CR) and sleep lower serum tyrosine levels. We previously showed that tyrosine inhibits tyrosyl-tRNA synthetase (TyrRS)-mediated activation of poly-ADP-ribose polymerase 1 (PARP1). Here, we show that histone serine-ADP-ribosylation is decreased in Alzheimer’s Disease (AD) brains, and increased tyrosine levels deplete TyrRS and cause neuronal DNA damage. However, dopamine and brain-derived neurotrophic factor (BDNF) increase TyrRS and histone serine-ADP-ribosylation. Furthermore, cis-resveratrol (cis-RSV) that binds to TyrRS mimicking a ‘tyrosine-free’ conformation increases TyrRS, facilitates histone serine-ADP-ribosylation-dependent DNA repair, and provides neuroprotection in a TyrRS-dependent manner. Conversely, trans-RSV that binds to TyrRS mimicking a ‘tyrosine-like’ conformation decreases TyrRS, inhibits serine-ADP-ribosylation-dependent DNA repair, and induces neurodegeneration in rat cortical neurons. Our findings suggest that age-associated increase in serum tyrosine levels may effect neurocognitive and metabolic disorders and offer a plausible explanation for divergent results obtained in clinical trials using resveratrol.
Deep learning driven biosynthetic pathways navigation for natural products with BioNavi-NP
Authors: Zheng Shuangjia , Zeng Tao , Li Chengtao , Chen Binghong , Coley Connor W. , Yang Yuedong , Wu Ruibo 
Published: June 2022

AbstractThe complete biosynthetic pathways are unknown for most natural products (NPs), it is thus valuable to make computer-aided bio-retrosynthesis predictions. Here, a navigable and user-friendly toolkit, BioNavi-NP, is developed to predict the biosynthetic pathways for both NPs and NP-like compounds. First, a single-step bio-retrosynthesis prediction model is trained using both general organic and biosynthetic reactions through end-to-end transformer neural networks. Based on this model, plausible biosynthetic pathways can be efficiently sampled through an AND-OR tree-based planning algorithm from iterative multi-step bio-retrosynthetic routes. Extensive evaluations reveal that BioNavi-NP can identify biosynthetic pathways for 90.2% of 368 test compounds and recover the reported building blocks as in the test set for 72.8%, 1.7 times more accurate than existing conventional rule-based approaches. The model is further shown to identify biologically plausible pathways for complex NPs collected from the recent literature. The toolkit as well as the curated datasets and learned models are freely available to facilitate the elucidation and reconstruction of the biosynthetic pathways for NPs.
Giant bulk photovoltaic effect driven by the wall-to-wall charge shift in WS2 nanotubes
Authors: Kim Bumseop , Park Noejung , Kim Jeongwoo 
Published: June 2022

AbstractThe intrinsic light–matter characteristics of transition-metal dichalcogenides have not only been of great scientific interest but have also provided novel opportunities for the development of advanced optoelectronic devices. Among the family of transition-metal dichalcogenide structures, the one-dimensional nanotube is particularly attractive because it produces a spontaneous photocurrent that is prohibited in its higher-dimensional counterparts. Here, we show that WS2 nanotubes exhibit a giant shift current near the infrared region, amounting to four times the previously reported values in the higher frequency range. The wall-to-wall charge shift constitutes a key advantage of the one-dimensional nanotube geometry, and we consider a Janus-type heteroatomic configuration that can maximize this interwall effect. To assess the nonlinear effect of a strong field and the nonadiabatic effect of atomic motion, we carried out direct real-time integration of the photoinduced current using time-dependent density functional theory. Our findings provide a solid basis for a complete quantum mechanical understanding of the unique light–matter interaction hidden in the geometric characteristics of the reduced dimension.