bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incision and drainage versus ultrasound guided needle aspiration in the management of lactational breast abscess.
Authors: Mansoor Bhatti Aisha , Iqbal Memon Amir , Naz Tarnum , Latif Sidra , Usman Sualeha , Gul Aisha 
Published: February 2022

Background: Lactational breast abscess is attributed to higher morbidities among women, specifically from developing countries. Though many treatment options are available, still consensus regarding the modality yielding the best outcome is scarce. The study's objective was to compare the outcome of lactational breast abscess following incision & drainage (ID) versus ultrasound-guided needle aspiration (USGNA).
Methodology: This prospective comparative investigation was carried upon a sample of 59 female patients with lactational breast abscess (chosen via non-probability, consecutive sampling), presenting to the Department of Surgery at Liaquat University Hospital, Hyderabad. The patients were divided into two groups, namely Group A (ID) and Group B (USGNA). Data was documented using a structured questionnaire, including inquiries related to sociodemographic details, disease specifics, and treatment outcomes (mainly abscess resolution, uninterrupted breastfeeding and fistula formation).
Results: The results showed that 3 patients (5.08%) from group A developed mammary fistula, 26 (44.06%) with complete resolution, and only 1 (1.69%) patient attained uninterrupted breastfeeding. In group B, there was full resolution in 28 (47.45%) patients, and the abscess of 2 (3.38%) patients did not completely resolve, while 28 (47.45%) attained uninterrupted breastfeeding.
Conclusion: It can be concluded that USGNA yields a better outcome in the treatment of lactational breast abscess in terms of lesser incidence of fistula development, the better probability of complete resolution and a significantly higher rate of attainments of the ability to breastfeed uninterruptedly.
Open diaphyseal fracture of the tibia in Pakistani adults: A comparative study of Plaster of Paris cast vs. Naseer Awais external fixator.
Authors: Kumar Beesham , Bhutto Irshad , Syed Muhammad Ali  , Kumar Ashok , Butt Siraj Amed , Memon Abbas , Ahmed Memon Iftikhar , Yasir Ali 
Published: February 2022

Background: The management of open tibial diaphyseal fractures is the most challenging glitch faced by orthopedic surgeons. For open or comminuted fractures, external fixation remains the gold standard. This study aimed to assess the treatment response of fixators by comparing the results of open diaphyseal tibial fracture stabilization in adults by Plaster of Paris (POP) cast versus Naseer Awais External Fixator (NAEF).
Methodology: A single-center, prospective study was conducted at the leading teaching institute and tertiary care hospital of Jamshoro and Hyderabad, Pakistan. A total of 30 patients having an open diaphyseal fracture of the tibia were randomly assigned to two groups (Group A-POP cast and Group B to NAEF; n=15 each). Duration of hospital stay and postoperative complications (like wound infection, union rate, and functional outcome) were compared between groups.
Results: On average, group A patients stayed in the hospital for 3.65 weeks, while group B patients stayed for 2.49 weeks (p=0.004). Wound infections were observed in 26.7% and 53.3% of the patients in group A and B, respectively. No significant difference in the adequate callus formation (i.e. union) and good functional outcome was observed among patients of group A and B (p>0.05).
Conclusion: The use of NAEF for open diaphyseal fractures of the tibia has a significant advantage over POP cast in reducing the duration of hospital stay. However, no significant differences were observed in wound infection, union rate and time, and functional outcome.
Frequency of morbidity, mortality and renal trauma in blunt and firearm accidents in pediatric population.
Authors: Ahmed Quraishi Mumtaz , Somroo Kashifuddin Qayoom , Chand Rewa , Rajar Zakir Hussain , Idrees Memon Imran , Yousuf Fakhir 
Published: February 2022

Background: Renal Trauma is one of the significant causes of deterioration, morbidity, and mortality in the pediatric age group around the globe. Firearm injuries are among one of the essential causes for renal trauma. Overall, trauma is the leading cause of death and accounts for approximately 50% of mortality in children over 1 year of age. Therefore, the current study aims to determine the frequency of morbidity, mortality and renal trauma in blunt and firearm accidents in pediatric population.
Methodology: A total of 180 children, aged up to 15 years with blunt and penetrating trauma, including firearm injuries, were enrolled in our study. All patients with in the inclusion criteria of the study, who were presented in the emergency department were evaluated and resuscitated by a pediatric surgeon. Patients indicated with renal trauma were operated and were post-operatively managed in the pediatric surgery ward. All patients included were followed as an outpatient. The data of this descriptive case series were collected prospectively and was analyzed on SPSS version 22.0.
Results: Out of 180 patients 110 (61.11%) were male and 70 (38.89%) were female with mean age of 8.5 ± 2.9 years. Majority of the patients had blunt trauma (54.44%) followed by firearm injuries (60, 33.33%). While penetrating trauma were observed in 22 patients (12.22%). Overall Renal trauma was observed in 40 (22.2%) of patients. Out of 40 patients, 20 (50%) patients had blunt, while 14 (35%) had firearm and 05 (12.5%) had penetrating abdominal trauma. Majority of renal injuries were Grade II (60%) followed by Grade III (17.5%), Grade IV (12.5%) and Grade I (10%) injury. The major morbidities noted in firearm injured patients were surgical site infection that was reported in 33.33% patients, limb deformity in 6.66% and neurological deficit in 5% patients. Overall Mortality was observed in 6.6% patients and firearm injuries was responsible for 8.33%.
Conclusion: Firearm injuries are one of the significant causes of trauma in children. The renal trauma was observed in 22.2% of cases, and all were managed conservatively. The frequency of morbidity and mortality secondary to firearm injuries was high as compared to other studies.
Antimicrobial evaluation of modified herbal and allopathic dental rinse solution against virulent strains.
Authors: Yacoob Bawa Mariyah , Aqeel Afsheen , Asif Saima , Bano Saeeda , Abbas Tanveer 
Published: February 2022

Background: Mouthwashes are antiseptic solutions and produce anti-inflammatory properties against periodontal infections in humans. Several in-vitro studies have been performed against virulent strains, as evidenced by an appropriate knowledge about their quality, effectiveness and safety in this research. This study is designed to test the antimicrobial effects and evaluation of mouthwashes against pathogens involved in dental caries and oral infections.
Methodology: Rinse solution (Mouthwash) has been developed by three different formulations. Anti-caries solutions were applied and checked against virulent bacterial and fungal pathogens. The antimicrobial effectiveness was identified using the agar well diffusion method and minimum inhibitory concentration (MIC).
Results: Chemisol showed potential killing activity and a zone of inhibition against pathogens ranging in 21-30 mm, which comparatively have higher zones than biosol and herbisol. Biosol also indicated efficacy within 11-13 mm zone of inhibition against Salmonella typhi ATCC-14028, Salmonella enterica ATCC-6017 resistant to herbisol and chemisol. Moreover, biosol exhibited greater MIC against most microorganisms at direct concentration and 1:10 dilution compared to herbisol and chemisol.
Conclusion: The significant difference observed in the antimicrobial activities of herbal, herbal & allopathic combination and allopathic dental washes against pathogenic strains. This study concluded that proper gargling with mouth wash solutions reduces the risk of life-threatening strains from fecal water & food.
Prevalence of fear-avoidance belief in patients with neck and back pain seeking physiotherapy.
Authors: Afzal Jaweria , Yasmeen Samreen , Ishaque Farhan , Nazar Bakhtawar , Naz Areesha , Azhar Esha 
Published: February 2022

Background: Fear-avoidance beliefs and signs specifically non-organics are considered the psychological factors that have been determined in playing a major role in the advancement of prolonged disability. The current study was directed to explore the prevalence of fear-avoidance belief in patients with neck and back pain seeking physiotherapy and identifying the superior level of fear-avoidance beliefs regarding work or bodily performances which causes chronicity and disability in patients.
Methodology: An observational study was conducted at the Institute of Physical Medicine & Rehabilitation, Dow University of Health Sciences, Ojha Campus, Karachi-Pakistan, from 1st Dec 2019 to 29th Feb 2020. Standard Fear Avoidance Belief Questionnaire (FAB-Q) was used to assess the fear level. The queries determined from the questionnaire were distributed into two types; FABQ-work-related and FABQ-physical activity-related.
Results: A total of 100 patients were included in the study, with a mean age of 45.76 ± 13.75 years. 39.0% patients reported neck pain, whereas 61.0% reported back pain. The prevalence of fear-avoidance belief related to physical activity was 90% and related to work was 91%. The results also showed a significant association between gender and work-related fear-avoidance belief with a p-value of 0.024 (≤ 0.05).
Conclusion: It is concluded that neck and backache sufferers show a high prevalence of fear-avoidance behavior of physical pastime and work score, confining their daily activities and not taking part in any bodily activities due to fear.
Effectiveness of ischemic compression pressure versus spray and stretch technique in the management of active myofascial trigger points of trapezius muscle.
Authors: Khan Urooj , Akhter Saeed , Khan Muhammad , Mirza Baig Aftab Ahmed 
Published: February 2022

Background: Now, a days myofascial trigger points are tremendously occurring and become a stressful part of nearly any person at any time in a lifetime. This study compares the effects of ischemic compression pressure with spray and stretch technique to treat active myofascial trigger points of the trapezius muscle in patients with neck pain.
Methodology: A comparative interventional study was conducted at Dow University of Health Sciences from December 2016 and May 2017. Seventy patients (35 in each group) with active myofascial trigger points of trapezius were randomly assigned to group A (ischemic compression pressure) and group B (vapocoolant spray and stretch technique). Baseline and last session assessment of pain intensity, pain pressure tolerance, cervical range of motion and functional disability were measured through numerical pain-rating scale, algometer, goniometer and neck disability index, respectively.
Results: Both groups showed significant improvement in all dependent variables of study which were neck pain, cervical range of motion and pain pressure tolerance (p-value<0.05). Group A showed greater improvement in pain intensity (p-value 0.015), pressure pain threshold (p-value 0.000) and cervical range of motion flexion, left side flexion and right-side flexion (p-value 0.002, 0.000 & 0.004) than group B.
Conclusion: Both ischemic compression pressure & spray and stretch technique deactivated trigger points of upper fibers trapezius muscle in patients with neck pain, but the ischemic compression pressure was superior to the spray and stretch technique.
Comparison of the effectiveness of dry needling with dry cupping at upper trapezius muscle in patients with myofascial trigger points.
Authors: Shoukat Imran , Nawaz Fozia , Shoukat Khadija , Shoukat Muhammad Adnan , Shoukat Muhammad Usman 
Published: February 2022

Background: Trigger points are palpable nodules or irritable spots present in the skeletal muscles, painful upon pressure. This study is concerned with the pain in the upper Trapezius muscle due to the formation of myofascial trigger points and to make a comparison of the effectiveness of dry needling with dry cupping for treating upper trapezius myofascial trigger points.
Methodology: Myofascial trigger points were diagnosed in 30 individuals in the upper trapezius. Subjects were randomized into Group-A (n=15) and Group-B (n=15) using the coin toss method. Patients were evaluated at baseline and after the termination of intervention using the Numeric Pain Rating Scale (NPRS), Neck Disability Index (NDI) and cervical joint range of motions (ROM). Patients from both groups received three sessions of treatment on alternate days in one week.
Results: Patients with both interventions resulted in significant improvement of NPRS (p=0.001), NDI (p=0.001), and cervical ranges of motion (p=0.001). However, between groups comparison of outcome measure showed no significant difference in NPRS (p=0.990), NDI (p=0.359), cervical flexion (p=0.457), cervical extension (p=0.382), right cervical lateral flexion (p=0.250), left cervical lateral flexion (p=0.792), right cervical rotation (p=0.336), and left cervical rotation (p=0.242) of motion.
Conclusion: The pre-and post-intervention results have concluded that both treatment methods effectively treat myofascial trigger points. There was no significant difference between the two groups for numeric pain rating scale, neck disability index scoring and cervical range of motions.
Effects of wearing modern hijab on cervical range of motion in female students in a private college of Karachi.
Authors: Aziz Khalid , Ali Seyyda Tahniat , Fahim Muhammad Faisal , Khan Rabia , Shahid Ghousia 
Published: February 2022

Background: Cervical spine allow maximum and necessary movements for the functioning of head and sensory organs. Any issue with the flexibility and joint movement can be determined by assessing the cervical range of motion. Cervical range of motion (CROM) assessment is commonly used in clinical practice. The current study aims to find the effects of wearing a hijab on the cervical range of motion compared to the normal cervical range of motions.
Methodology: A cross-sectional study was conducted among hijab-wearing female students from Bahria University Medical and Dental College, from November 2019 to January 2020. The study subjects were recruited using a CROM device. Hijab-wearing female students between 18–23 years of age who wear hijab for at least 3 months, with the duration of wearing hijab for at least or at most 6 hours/day were included in the study.
Results: A total of 384 students were recruited. Mean Cervical flexion for wearing hijab ≤ 6 hours was 61.06 ± 17.19, and > 6 hours was 55.28 ± 16.09 (p<0.001). Mean extension for wearing hijab ≤ 6 hours was observed to be 41.03 ± 12.89 and for > 6 hours was 37.96 ± 10.94 (p=0.008). Mean Lateral flexion for wearing hijab ≤ 6 hours was 42.66 ± 10.32, and > 6 hours was 38.96 ± 11.01 (p=0.002). While mean right rotation for wearing hijab ≤ 6 hours was 59.50 ± 14.27, and 6 hours was 63.47 ± 14.13 (p=0.010). Moreover, the mean Left rotation for wearing hijab ≤ 6 hours was 64.66 ± 17.86, and >6 hours was 70.58 ± 14.34 (p=0.001).
Conclusion: The routine wearing of the hijab affects cervical mobility. Moreover, it is concluded that wearing a hijab for > 6 hours greatly affects the range of the head for movement, by decreasing the cervical range of motion.
Single stage management of chronic posterolateral knee dislocation in a middle-aged man - A Case Report.
Authors: Qamar Adnan , Ali Haider , Muhammad Abdul Shakoor  , Amjad Usman , Shah Syed Wasif Ali 
Published: February 2022

Background: Posterolateral knee dislocation rarely occur and might not reduce due to buttonholing of the Femoral condyle into the anteromedial knee joint capsule. These are complex injuries without any clear guidelines in terms of management.
Case presentation: 40-year-old male presented with posterolateral knee dislocation due to a road traffic accident. Patient was having posterior cruciate ligament (PCL) injury along with posterolateral corner instability supported by clinical examination and confirmed with radiologic investigations.
Management and Results: Patient was managed with single-stage arthroscopic reconstruction of PCL followed by open posterolateral corner ligaments reconstruction. Postoperatively patient had positive functional outcomes with satisfactory international knee documentation committee subjective knee form (IKDC) scores.
Conclusion: Posterolateral Corner Injury (PLC) injury with associated PCL injury showed positive results when managed in a single-stage procedure.
Glutamate ionotropic receptor AMPA type subunit 1 gene polymorphism (Gly>Ser) and its association with schizophrenia in Pakistani population: A pilot Study.
Authors: Javed Ariba , Batool Malik Ayesha , Amir Qurat-ul-Ain , Hanif Farina , Washdev  , Jawed Lalarukh 
Published: February 2022

Background: Neurobiology of schizophrenia involves impairment of glutamatergic neurotransmission. In this context, polymorphism in glutamate Ionotropic receptor a-amino-3-hydroxy-5-methyl-4-propionic acid (AMPA) type subunit 1 encoded by Glutamate Ionotropic Receptor AMPA Type Subunit 1 Gene (GRIA), (rs1127386, G/A) can be considered as a substantial contributor in pathogenesis of schizophrenia. Therefore, a pilot study was planned to find out if the single nucleotide polymorphism of GRIA (rs1127386, G/A) is a risk factor for schizophrenia in the population of Pakistan. It maps at 5q33, a schizophrenia susceptible locus as per genome-wide association studies.
Methodology: Following Diagnostic and Statistical Manual 5 (DSM 5) criteria guidelines, 50 schizophrenia cases were incorporated in this case-control study and 51 controls, individuals without any psychiatric illness. The sternness of illness was figured out using positive and negative syndrome scale score (PANSS) score. Genomic DNA was extracted from blood, and further analysis was done on gel electrophoresis after conducting ARMS (amplification refractory mutation system) PCR. Frequencies of reported genotype and allele within both groups were determined using the chi-square test.
Results: Statistically significant difference was not found in genotype and allele frequencies of (rs1127386, G/A) (p>0.05) between cases and controls in the study population. The severity status of the disease was also independent of the polymorphism (p>0.05).
Conclusion: This pilot study specifies that polymorphism rs1127386 is not a risk factor for schizophrenia, at least in the Pakistani population.
Risk factors for blood loss in liver resection surgery: An Institutional Review.
Authors: Khan Muhammad Shadab , Khan Muhammad Attaullah , Saba Ayesha , Amir Sana , Anwar Abdul Wahid 
Published: February 2022

Background: Surgical resection of the primary or metastatic liver lesions is the treatment of choice for patients with resectable tumors. Identifying and managing preoperative and intraoperative risk factors responsible for increased blood loss during liver resection is extremely important. Therefore, the present study aims to identify preoperative and intraoperative risk factors associated with blood loss during liver resection.
Methodology: A retrospective cross-sectional study was conducted on 72 patients who underwent liver resection for resectable primary and metastatic liver lesions at the Department of Surgical Oncology Hepatobiliary Unit, Shaukat Khanum Memorial Cancer Hospital, and Research Center Lahore. The study continued from October 2014 to July 2017, and data were collected from hospital records, including demographic, biochemical, and perioperative variables.
Results: Out of the total 38 patients, 52.8% were female, with a mean age of 40.59 ± 21.66 years at the time of surgery. The results after multivariate analysis conclude two independent risk factors responsible for significant blood loss of more than 1000 milliliters during liver resection. These factors include liver cirrhosis, where the odds ratio is 7.96 with 95% CI (1.00-63.31) and P-value of 0.05 and operative time of 390 minutes where odds ratio is 8.94 with 95% CI (2.28-36.48) and P-value of 0.02.
Conclusion: The risk factors associated with increased intraoperative blood loss during liver resections in our population are mainly associated with preoperative parameters, including positive viral serology and radiologically proven liver cirrhosis. In contrast, intraoperative factors were intravenous fluid administration and operative time.
Perceptive on bacteriological quality in foods of animal origin sold in the local market: Potential threats for the perishable food supply chain
Authors: Aqeel Afsheen , Ali Meerani Zulfiqar , Yacoob Bawa Mariyah , Asif Saima , Noor Rabia , Khan Shumaila , Abbas Tanveer 
Published: February 2022

Background: Pre and post-harvest spoilage is becoming a severe concern not only in Pakistan but also worldwide. Foodborne illness remains prevalent throughout Pakistan because of the lack of informed risks and safe handling practices of the food preparers and handlers at each food chain point. It causes food spoilage that results in substantial economic losses to both producers (farmers) and consumers. Therefore, this article aimed to review the microbial load of meat, dairy, and seafood products and how the microbial load/population's shelf life and food quality can be affected.
Methodology: During this experimental study, a total 127 samples were collected directly from different industries and included. Total bacterial count (TBC), total coliform count (TCC), fecal coliform count (FCC) and detection of Salmonella were done to check the quality of foods of animal origin collected from the different food industries from 2019 to 2020 and Pakistan standard (P.S.) of food quality was used to compare the results.
Results: Among 127 analyzed samples, 27 (34.29%) samples were found contaminated with four bacterial parameters, TBC (6.35%), TCC (19%), and FCC (8.89%). At the same time, Salmonella spp were found absent in all of the samples analyzed. Among seven perishable food commodities, the higher percentage of unsatisfactory samples were observed in the chicken meat (1.62%) and beef meat samples (1.5%), while fresh milk was highly contaminated (0.9%) as compared to the powder milk (0.42%), followed by yogurt (0.26%). Shrimp (0.26%) and fish items (0.2%) showed the least percentage of unsatisfactory samples.
Conclusion: The results suggest that a significant quality difference is observed in the food items sold in the central region of Karachi, further representing a vulnerability to human health in terms of bacteriological hazards. Our findings suggest that safety measures should be taken seriously to stay away from possible uncertainties.