bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women’s Empowerment Without Power: Strategic v. Practical Interests in SDGs and the Voluntary National Reviews
Authors: Kim Nancy Y. , Bang Yoorim , Kim Eun Mee 
Published: July 2022

AbstractThis study examines country's voluntary national reviews (VNRs) to assess global commitment to gender equality in the era of the Sustainable Development Goals (SDGs). While the SDGs promise realisation of gender equality, progress data indicate that gender equality will not be achieved in the next century, let alone by the SDGs target date of 2030. This study posits two explanations for slow progress on gender equality: (i) countries selectively pursue gender equality, as evidenced by our finding that country VNRs demonstrated commitment to achieving only 31% of extant gender equality gaps;and (ii) countries are more committed to achieving gender equality on ‘practical’ dimensions (i.e., relating to basic needs, such as maternal health and education) than ‘strategic’ dimensions which seek to challenge unequal power relations and women's subordinate position within society (e.g., income, land, political power). Whether via refinements to the SDG/VNR process, or through well‐established gender platforms such as the World Economic Forum Global Gender Gap Index and Equal Measures 2030 SDG Gender Index, gender equality advocates must push for pursuit of the entirety of the holistic gender equality agenda as hard‐fought for and agreed by the seminal Beijing Platform for Action. Without greater attention to strategic dimensions, women will be stuck in a vicious cycle of ‘empowerment without power’ and gender equality will elude women for yet another century.
Comprehensive genetic analysis of histological components of combined small cell carcinoma
Authors: Iida Yuko , Nakanishi Yoko , Shimizu Tetsuo , Nomoto Masayuki , Nakagawa Yoshiko , Ito Reiko , Takahashi Noriaki , Masuda Shinobu , Gon Yasuhiro 
Published: July 2022

AbstractBackgroundCombined small‐cell lung cancer (cSCLC) is a rare type of small‐cell lung cancer (SCLC) that includes both SCLC and non‐small‐cell lung cancer (NSCLC). The molecular biological mechanisms underlying the heterogeneity of histological types in combined or metachronously transformed SCLC (mtSCLC) remain unclear. This study aimed to investigate the relationship between genetic alterations and each histological component heterogeneously detected in cSCLC and mtSCLC.MethodsThis study included four cSCLC cases and one mtSCLC case. Formalin‐fixed and paraffin‐embedded sections of each histological component of these tumors were subjected to next‐generation sequencing (NGS) and quantitative reverse transcription‐polymerase chain reaction to investigate the genetic mutations and expression levels of neuroendocrine cell‐specific transcription factors (achaete‐scute homolog‐1 [ASCL1], brain‐2 [BRN2] also known as POU domain class 3 transcription factor 2, nuclear factor 1 B [NF1B], insulinoma‐associated protein 1 [INSM1], and thyroid transcription factor‐1 [TTF‐1]).ResultsNGS analysis revealed that SCLC and NSCLC components share the same somatic mutations detected most frequently in TP53, and also in RB1 and EGFR. Gene expression analysis showed ASCL1 expression was significantly lower in the NSCLC component than in the SCLC component.ConclusionWe conclude that the morphological evolution of heterogeneous histological components in cSCLC may be associated with differences in ASCL1 expression levels, but not in acquired somatic gene mutations.
Curtailment as a successful method for reducing bat mortality at a southern Australian wind farm
Authors: Bennett Emma M. , Florent Stevie Nicole , Venosta Mark , Gibson Matthew , Jackson Alex , Stark Elizabeth 
Published: July 2022

AbstractWind energy is a rapidly expanding renewable technology with massive global investments; however, operating turbines are associated with bat strikes globally, and evidence suggests that without intervention, wind farm collisions could drive some common species to extinction. One widely regarded method for reducing strike mortality is operational mitigation, or curtailment, where turbine operation is restricted at low wind speeds. Despite an increasing number of studies in the Northern Hemisphere demonstrating curtailment effectiveness, no empirical studies have yet been conducted in Australia. This paper reports the findings of a curtailment study implemented at the Cape Nelson North wind farm in southwest Victoria, Australia. Conservation detection dog teams conducted mortality surveys between January and April in 2018 (before; pre‐curtailment) and 2019 (after; during curtailment). Results were consistent with similar studies in the USA and Europe, as curtailment significantly reduced pooled species mortality by 54%. Bat calls did not decline during the study period, and thus were not an explanation for the reduction in fatalities. This study demonstrates that curtailment is a valid method for reducing bat turbine collision in south‐eastern Australia. Consideration should be given to curtailment as a means to reduce bat turbine impacts in Australia, particularly at sites with known endangered and threatened populations, as we act to reduce anthropogenic climate change and its time‐sensitive negative consequences.
Secukinumab treatment showed improved quality of life in patients with chronic plaque psoriasis in Australia: Results from the HOPE study
Authors: Foley Peter , Spelman Lynda , Murrell Dedee F. , Mate Eric , Tronnberg Rebecca , Lowe Patricia M. 
Published: July 2022

AbstractBackgroundPsoriasis imposes a disease burden that can have a profound negative impact on patients' quality of life (QoL). HOPE was the first non‐interventional study conducted in patients with severe chronic plaque psoriasis in Australia that evaluated health‐related QoL in response to treatment with secukinumab.MethodsHOPE was a prospective, open‐label, single‐arm, multicentre, non‐interventional, exploratory study in patients with severe chronic plaque psoriasis in Australia. The study investigated the change in QoL, using the Dermatology Life Quality Index (DLQI), Assessment Quality of Life‐8 Dimension questionnaire (AQoL‐8D) and Psoriasis Area and Severity Index (PASI), and safety profile in response to treatment with secukinumab 300 mg SC weekly for 4 weeks followed by monthly maintenance for 58 weeks.ResultsAt Week 14, the mean percentage reduction in total DLQI score from baseline was −82.4% (n = 65), which indicates a substantial improvement in QoL. This level of improvement was sustained up to Week ≥58, with a mean percentage change of −87.4%. The mean percentage change from baseline for AQoL‐8D weighted total score decreased from Week 14 (41.1%) to Week 58 (35.2%), indicating an improvement in patients' QoL. A high proportion of patients achieved PASI 75/90/100 responses at Week 14 (97.0%/71.2%/34.8%), with rates sustained up to Week ≥58 (100%/87.9%/43.1%). The safety profile of secukinumab was favourable, with no cumulative or unexpected safety concerns.ConclusionSecukinumab treatment demonstrated a striking improvement in patients' QoL in the HOPE study, the first real‐world study in patients with severe chronic plaque psoriasis in the Australian clinical setting.
Non‐immediate hypersensitivity reactions to iomeprol: Diagnostic value of skin tests and cross‐reactivity with other iodinated contrast media
Authors: Gamboa Pedro , Sánchez de Vicente Javier , Galán Cristina , Jáuregui Ignacio , Segurola Aritza , García‐Lirio Eduardo , Seras Yolanda , Martínez‐Antón Mª. Dolores , Arrien de Lecea Angel 
Published: July 2022

AbstractBackgroundIodinated contrast media produce non‐immediate hypersensitivity reactions (NIHR). The goal of this prospective study was to determine the utility of skin tests and the subsequent tolerance to negative skin‐tested iodinated contrasts in patients with NIHR caused by iomeprol.MethodsPrick and intradermal tests with iomeprol, iopamidol, iopromide, and iobitridol were performed in all patients. IV challenge with the causative contrast (iomeprol in 90%) was made if skin tests were negative. In case of a positive skin test with the causal contrast, or a positive challenge test with it, IV challenge test with an alternative, negative skin‐tested contrast was performed in all patients.ResultsSkin tests were positive in 47.6% (20/42) of patients with NIHR induced by iomeprol. Of the 66 challenge tests performed with negative skin‐tested iodinated contrasts, tolerance was confirmed in 35 (53%): 32 iomeron, 2 iobitridol, 1 iopamidol. Cross‐reactivity between iomeprol and iopamidol was 22% (4/20 in patients with positive skin tests and 5/21 in patients with negative skin tests).ConclusionsSensitivity of the skin tests was less than 50% NIHRs due to iomeprol, while the negative predictive value of skin tests in patients who tolerated challenges with alternative contrasts (mainly iopamidol) was 53% (35 tolerated out of 66 performed). The cross‐reactivity between iomeprol and iopamidol is high.
Esteeming goods for non‐accumulation, small realms with few people: Interpreting kula withLaozi
Authors: Liang Yongjia 
Published: July 2022

AbstractThis article interprets the kula system through the lens of theLaozi, a Chinese classic of the 6th century BCE. Laozi's ideas regarding “esteeming goods,” “non‐accumulation,” and “small realms with few people” allow us to understand why kula shells and names are precious but impossible to accumulate and how kula serves to keep societies small and peaceful with its subtle practice of organizations, technologies, and calendars. Through exemplary “elders” who esteem goods hard to accumulate, the kula operates as a void system close to the spontaneous order idealized by Laozi, who promoted the ideal of the non‐accumulative Sage. Epistemologically, the article continues the anthropological tradition of perspectivist comparison by proposing a Sinic interpretation, a version of multi‐universalism that does not intend to invalidate the existing universalism but seeks to transcend the view of a singular western universalism and multiple non‐Western exceptionalisms.
Review article: Diagnosis of coeliac disease: a perspective on current and future approaches
Authors: Anderson Robert P. 
Published: July 2022

SummaryDiagnostics will play a central role in addressing the ongoing dramatic rise in global prevalence of coeliac disease, and in deploying new non‐dietary therapeutics. Clearer understanding of the immunopathogenesis of coeliac disease and the utility of serology has led to partial acceptance of non‐biopsy diagnosis in selected cases. Non‐biopsy diagnosis may expand further because research methods for measuring gluten‐specific CD4+ T cells and the acute recall response to gluten ingestion in patients is now relatively straightforward. This perspective on diagnosis in the context of the immunopathogenesis of coeliac disease sets out to highlight current consensus, limitations of current practices, gluten food challenge for diagnosis and the potential for diagnostics that measure the underlying cause for coeliac disease, gluten‐specific immunity.
Ovarian maturation of Penaeus subtilis (Decapoda: Penaeidae): A new insight to describe oocyte development and somatic structures
Authors: Craveiro Cecília , Soares Roberta , Castro‐Neto Hildemário , Silva Emanuell F. , Soares Andrey , de Oliveira Paulo G. V. , Gonzalez Evelyn , Peixoto Silvio 
Published: July 2022

AbstractWe observed the presence of follicular cells (FC) in the ovaries of Penaeus subtilis (n = 1198), which led us to classify the development of germ cells into six phases: oogonia, previtellogenic oocytes, primary and secondary vitellogenic oocytes, mature oocytes and atretic oocytes. The FC changes their shape according to the development of germ cells and showed a different distribution along the ovary, which allowed differentiating vitellogenic oocytes into primary and secondary. We also observed that the postovulatory follicles (POF) are composed of follicular cells. The presence of POF in penaeids ovaries is rarely reported, but allows the differentiation between spent and resting stages, commonly grouped in reproductive biology research. Furthermore, observation of ovarian lining was useful to differentiate immature females from females that had spawned at least once. Thus, ovarian development was classified into six stages: immature, early developing, advanced developing, ripe, spent and resting. The distribution and shape variations of FC, ovarian lining features and presence of POF were considered crucial for the classification of ovarian maturation stages. The methods developed here may improve estimates of their reproductive cycle, size at first maturity and spawning season, which are important variables in future studies of the reproductive dynamics.
Basal extrusion of single‐oncogenic mutant cells induces dome‐like structures with altered microenvironments
Authors: Shirai Takanobu , Sekai Miho , Kozawa Kei , Sato Nanami , Tanimura Nobuyuki , Kon Shunsuke , Matsumoto Tomohiro , Murakami Takeru , Ito Shoko , Tilston‐Lunel Andrew , Varelas Xaralabos , Fujita Yasuyuki 
Published: July 2022

AbstractAt the initial stage of carcinogenesis, oncogenic transformation occurs in single cells within epithelial layers. However, the behavior and fate of the newly emerging transformed cells remain enigmatic. Here, using originally established mouse models, we investigate the fate of RasV12‐transformed cells that appear in a mosaic manner within epithelial tissues. In the lung bronchial epithelium, most majority of RasV12‐transformed cells are apically extruded, whereas noneliminated RasV12 cells are often basally delaminated leading to various noncell‐autonomous changes in surrounding environments; macrophages and activated fibroblasts are accumulated, and normal epithelial cells overlying RasV12 cells overproliferate and form a convex multilayer, which is termed a ‘dome‐like structure’. In addition, basally extruded RasV12 cells acquire certain features of epithelial–mesenchymal transition (EMT). Furthermore, the expression of COX‐2 is profoundly elevated in RasV12 cells in dome‐like structures, and treatment with the COX inhibitor ibuprofen suppresses the recruitment of activated fibroblasts and moderately diminishes the formation of dome‐like structures. Therefore, basal extrusion of single‐oncogenic mutant cells can induce a tumor microenvironment and EMT and generate characteristic precancerous lesions, providing molecular insights into the earlier steps of cancer development.
Monthly income volatility and health outcomes
Authors: Bania Neil , Leete Laura 
Published: July 2022

AbstractA growing literature shows that income volatility has negative effects on household well‐being. Using the Survey of Income and Program Participation, we use temporal ordering to investigate the relationship between monthly household income volatility and the subsequent change in self‐reported health status of the household head. For liquidity constrained households, a one standard deviation increase in volatility over 24 months leads to a 1.3%–4.3% increase in the probability of worsened health. The magnitude of this effect is approximately two‐thirds that of the impact of a one standard deviation change in the level of mean household income.
PAPPA2 mutation as a novel indicator stratifying beneficiaries of immune checkpoint inhibitors in skin cutaneous melanoma and non‐small cell lung cancer
Authors: Dong Yiting , Zhao Lele , Duan Jianchun , Bai Hua , Chen Dongsheng , Li Si , Yu Yangyang , Xiao Mingzhe , Zhang Qin , Duan Qianqian , Sun Tingting , Qi Chuang , Wang Jie , Wang Zhijie 
Published: July 2022

AbstractBackgroundPappalysin 2 (PAPPA2) mutation, occurring most frequently in skin cutaneous melanoma (SKCM) and non‐small cell lung cancer (NSCLC), is found to be related to anti‐tumour immune response. However, the association between PAPPA2 and the efficacy of immune checkpoint inhibitors (ICIs) therapy remains unknown.MethodsTo analyse the performance of PAPPA2 mutation as an indicator stratifying beneficiaries of ICIs, seven public cohorts with whole‐exome sequencing (WES) data were divided into the NSCLC set (n = 165) and the SKCM set (n = 210). For further validation, 41 NSCLC patients receiving anti‐PD‐(L)1 treatment were enrolled in China cohort (n = 41). The mechanism was explored based on The Cancer Genome Atlas database (n = 1467).ResultsIn the NSCLC set, patients with PAPPA2 mutation (PAPPA2‐Mut) demonstrated a significantly superior progress free survival (PFS, hazard ratio [HR], 0.28 [95% CI, 0.14–0.53]; p < 0.001) and objective response rate (ORR, 77.8% vs. 23.2%; p < 0.001) compared to those with wide‐type PAPPA2 (PAPPA2‐WT), consistent in the SKCM set (overall survival, HR, 0.49 [95% CI: 0.31–0.78], p < 0.001; ORR, 34.1% vs. 16.9%, p = 0.039) and China cohort. Similar results were observed in multivariable models. Accordingly, PAPPA2 mutation exhibited superior performance in predicting ICIs efficacy compared with other published ICIs‐related gene mutations, such as EPHA family, MUC16, LRP1B and TTN, etc. In addition, combined utilization of PAPPA2 mutation and tumour mutational burden (TMB) could expand the identification of potential responders to ICIs therapy in both NSCLC set (HR, 0.36 [95% CI: 0.23–0.57], p < 0.001) and SKCM set (HR, 0.51 [95% CI: 0.34–0.76], p < 0.001). Moreover, PAPPA2 mutation was correlated with enhanced anti‐tumour immunity including higher activated CD4 memory T cells level, lower Treg cells level, and upregulated DNA damage repair pathways.ConclusionsOur findings indicated that PAPPA2 mutation could serve as a novel indicator to stratify beneficiaries from ICIs therapy in NSCLC and SKCM, warranting further prospective studies.
Intracellular antibody targeting HBx suppresses invasion and metastasis in hepatitis B virus‐related hepatocarcinogenesis via protein phosphatase 2A‐B56γ‐mediated dephosphorylation of protein kinase B
Authors: Che Lin , Du Ze‐Bang , Wang Wei‐Hua , Wu Jia‐Shen , Han Tun , Chen Yuan‐Yuan , Han Pei‐Yu , Lei Zhao , Chen Xiao‐Xuan , He Yun , Xu Ling , Lin Xu , Lin Zhong‐Ning , Lin Yu‐Chun 
Published: July 2022

AbstractObjectivesHepatitis B virus X (HBx) is closely associated with HBV‐related hepatocarcinogenesis via the inactivation of tumour suppressors. Protein phosphatase 2A (PP2A) regulatory subunit B56 gamma (B56γ), as a tumour suppressor, plays a critical role in regulating cellular phosphorylation signals via dephosphorylation of signalling proteins. However, the underlying mechanism that B56γ involved in regulating HBx‐associated hepatocarcinogenesis phenotypes and mediating anti‐HBx antibody‐mediated tumour suppression remains unknown.Materials and MethodsWe used bioinformatics analysis, paired HCC patient specimens, HBx transgenic (HBx‐Tg) mice, xenograft nude mice, HBV stable replication in the HepG2.2.15 cells, and anti‐HBx antibody intervention to systematically evaluate the biological function of protein kinase B (AKT) dephosphorylation through B56γ in HBx‐associated hepatocarcinogenesis.ResultsBioinformatics analysis revealed that AKT, matrix metalloproteinase 2 (MMP2), and MMP9 were markedly upregulated, while cell migration and viral carcinogenesis pathways were activated in HBV‐infected liver tissues and HBV‐associated HCC tissues. Our results demonstrated that HBx‐expression promotes AKT phosphorylation (p‐AKTThr308/Ser473), mediating the migration and invasion phenotypes in vivo and in vitro. Importantly, in clinical samples, HBx and B56γ were downregulated in HBV‐associated HCC tumour tissues compared with peritumor tissues. Moreover, intervention with site‐directed mutagenesis (AKTT308A, AKTS473A) of p‐AKTThr308/Ser473 mimics dephosphorylation, genetics‐based B56γ overexpression, and intracellular anti‐HBx antibody inhibited cell growth, migration, and invasion in HBx‐expressing HCC cells.ConclusionsOur results demonstrated that B56γ inhibited HBV/HBx‐dependent hepatocarcinogenesis by regulating the dephosphorylation of p‐AKTThr308/Ser473 in HCC cells. The intracellular anti‐HBx antibody and the activator of B56γ may provide a multipattern chemopreventive strategy against HBV‐related HCC.
Iny Karajá Presence: Material and Visual Culture of Ritxoko Dolls in Museums
Authors: Morais de Andrade Rita , Duarte Cândido Manuelina Maria 
Published: July 2022

AbstractMuseums face the challenge of the lack of information on their museological documentation of ethnographic objects, specially those collected from indigenous peoples in an array of colonial and post‐colonial contexts. The PPK research project presented in this paper aims to contribute to the improvement of documentation on the Brazilian indigenous Iny Karajá dolls (ritxoko), which have been identified in museum collections around the world. This is most relevant to understudied collections in those museums expected to substantiate exhibitions, educational actions and other forms of access and communication of the collections to the public. In order to address the goal, the PPK project traces the dolls and the museums collections' trajectories, and targets at specifics such as the study of the dolls' clothing and body adornments. Participative research methodologies have proved to be critical as the interpersonal interfaces between researchers/institutions and Iny Karajá indigenous groups provides new data and a fresh understanding of the artifacts in the contexts of museum practices. The information has been organized in a database, which will be available at the digital Platform Tainacan. The usefulness of these findings to the museum field are to acknowledge and disseminate more accurately the Iny Karajá doll collections; to meet UNESCO's Recommendation on the Protection and Promotion of Museums and Collections (2015); and to account for ritxoko dress, seeking to discuss the place of indigenous artifacts at “ethnic” niches in museums.
MOHOA. A Lesson in Sustainability Given by Modern Heritage in the Democratic Republic of the Congo: The Sacred Architecture of Paul Dequeker
Authors: Michieletto Manlio , Mukanya Victor Bay 
Published: July 2022

AbstractThe Tropical Modernism that spread in the sub‐Saharan Africa, consigning to history many ancient architectural artifacts and practices. The Democratic Republic of the Congo preserves some precious examples of tropical architecture that were realized before and after independence. The aim of this paper is to examine this heritage and the sustainability already embedded in the language of tropical architecture, and its application in the design process through analyzing quintessential instances of Paul Dequeker's work, in particular his sacred architecture. Six projects in DR Congo are presented: King Christ Church, St. Anthony I Church, St. Luke Church, St. Augustine Church, St. Anthony II Church and St. Raphaël Church. This research explores each case study through a qualitative method analyzing, first, historical documents relating to their conception as architectural projects, and second, as part of an African modern heritage that needs to be classified, studied, and protected. Moreover, the analysis focuses on the tropical details and features characterizing the architectural artifacts.
Illiberal economic institutions and racial intolerance in the United States
Authors: Wright Walker 
Published: July 2022

AbstractThis article presents the history of anti‐black racism in the United States as a case study of the interrelation between economic institutions and racial (in)tolerance. It begins by reviewing the current social science on the topic of economic systems and tolerance. It then moves from the history of slavery through Reconstruction and the Jim Crow era to the Civil Rights movement, demonstrating that government intervention in the economy helped maintain a racial hierarchy and solidify racist attitudes. The article concludes by arguing that liberal economic institutions are a means of dissolving segregated racial orders and creating more tolerant, integrated ones.