bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatized FACEmemory® scoring is related to Alzheimer’s disease phenotype and biomarkers in early-onset mild cognitive impairment: the BIOFACE cohort
Authors: Alegret Montserrat , Sotolongo-Grau Oscar , de Antonio Ester Esteban , Pérez-Cordón Alba , Orellana Adelina , Espinosa Ana , Gil Silvia , Jiménez Daniel , Ortega Gemma , Sanabria Angela , Roberto Natalia , Hernández Isabel , Rosende-Roca Maitee , Tartari Juan Pablo , Alarcon-Martin Emilio , de Rojas Itziar , Montrreal Laura , Morató Xavier , Cano Amanda , Rentz Dorene M. , Tárraga Lluís , Ruiz Agustín , Valero Sergi , Marquié Marta , Boada Mercè 
Published: March 2022

Abstract
Background
FACEmemory® is the first computerized, self-administered verbal episodic memory test with voice recognition. It can be conducted under minimal supervision and contains an automatic scoring system to avoid administrator errors. Moreover, it is suitable for discriminating between cognitively healthy and amnestic mild cognitive impairment (MCI) individuals, and it is associated with Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers. This study aimed to determine whether FACEmemory scoring is related to performance on classical memory tests and to AD biomarkers of brain magnetic resonance imaging (MRI) and CSF in patients with early-onset MCI (EOMCI).

Methods
Ninety-four patients with EOMCI from the BIOFACE study completed FACEmemory, classical memory tests (the Spanish version of the Word Free and Cued Selective Reminding Test -FCSRT-, the Word List from the Wechsler Memory Scale, third edition, and the Spanish version of the Rey–Osterrieth Complex Figure Test), and a brain MRI. Eighty-two individuals also underwent a lumbar puncture.

Results
FACEmemory scoring was moderately correlated with FCSRT scoring. With regard to neuroimaging MRI results, worse execution on FACEmemory was associated with lower cortical volume in the right prefrontal and inferior parietal areas, along with the left temporal and associative occipital areas. Moreover, the total FACEmemory score correlated with CSF AD biomarkers (Aβ1-42/Aβ1-40 ratio, p181-tau, and Aβ1-42/p181-tau ratio). When performance on FACEmemory was compared among the ATN classification groups, significant differences between the AD group and normal and SNAP groups were found.

Conclusions
FACEmemory is a promising tool for detecting memory deficits sensitive to early-onset AD, but it also allows the detection of memory-impaired cases due to other etiologies. Our findings suggest that FACEmemory scoring can detect the AD endophenotype and that it is also associated with AD-related changes in MRI and CSF in patients with EOMCI. The computerized FACEmemory tool might be an opportunity to facilitate early detection of MCI in younger people than 65, who have a growing interest in new technologies.
Oxaliplatin-induced thrombotic microangiopathy: a case report
Authors: Saad Rhea , Hannun Audra , Temraz Sally , Finianos Antoine , Zeenny Rony M. 
Published: March 2022

Abstract
Background
Oxaliplatin-based chemotherapy represents a standard of care in the treatment of metastatic colorectal cancer. We report a rare case of fulminant oxaliplatin-induced thrombotic microangiopathy, clinically suggestive of hemolytic–uremic syndrome, occurring in a female patient with a prolonged history of exposure to oxaliplatin for the treatment of metastatic colon cancer.

Case presentation
A 73-year-old Caucasian female with a treatment history including several lines of chemotherapy for the management of metastatic colon cancer was reinitiated on chemotherapy with oxaliplatin, fluorouracil, and leucovorin with bevacizumab for disease progression. She presented to the emergency department with malaise, headache, vomiting, and decreased urine output appearing a few hours after chemotherapy administration. Clinical symptoms and laboratory findings were suggestive of thrombotic microangiopathy, with a triad of microangiopathic hemolytic anemia, pronounced thrombocytopenia, and acute renal failure. The predominance of the severe renal failure was evocative of hemolytic–uremic syndrome. The rapid development of the thrombotic microangiopathy was linked to exposure to oxaliplatin. The patient was promptly managed with daily plasma exchange and high-dose corticosteroids, platelet, and red blood cell transfusions in conjunction with intermittent hemodialysis, and she recovered progressively.

Conclusion
Our case confirms the risk of hemolytic–uremic syndrome as a rare and life-threatening complication of oxaliplatin-based chemotherapy. A dose-dependent, drug-induced toxicity mechanism is suggested. Physicians need to maintain a high level of clinical suspicion to diagnose and treat this acute life-threatening disorder.
The effectiveness of virtual reality for rehabilitation of Parkinson disease: an overview of systematic reviews with meta-analyses
Authors: Lu Yaqin , Ge Yonggui , Chen Wanqiang , Xing Wenting , Wei Lushan , Zhang Caixia , Yang Yusheng 
Published: March 2022

Abstract
Background
An increasing number of systematic reviews (SRs) and meta-analyses (MAs) of clinical trials have begun to investigate the effects of virtual reality (VR) in patients with Parkinson disease (PD). The aim of this overview was to systematically summarize the current best evidence for the effectiveness of VR therapy for the rehabilitation of people with PD.

Methods
We searched SR-MAs based on randomized controlled trials (RCTs) for relevant literature in PubMed, Embase, and Cochrane library databases for systematic reviews from inception to December 5, 2020, and updated to January 26, 2022. The methodological quality of included SR-MAs was evaluated with the Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR-2), and the certainty of evidence for outcomes with the Grading of Recommendations, Assessment, Development and Evaluation (GRADE). We created an evidence map using a bubble plot format to represent the evidence base in 5 dimensions: effect size of VR therapy versus active intervention (AT), clinical outcome area, number of trials, statistical significance, and certainty of evidence.

Results
From a total of 585 reports, 12 reviews were identified, of which only one was rated moderate quality, three were rated low quality, and eight were rated critically low quality by AMSTAR 2. Compared with AT, VR therapy induced increased benefits on stride/step length, balance, and neuropsychiatric symptoms. Compared with passive intervention (PT), VR therapy had greater effects on gait speed, stride/step length, balance, activities of daily living, and postural control in people with PD. Certainty of evidence varied from very low to moderate.

Conclusions
We found the methodological quality of the reviews was poor, and certainty of the most evidence within them was low to very low. We were therefore unable to conclude with any confidence that, in people with PD, VR therapy is harmful or beneficial for gait, balance, motor function, quality of life, activities of daily living, cognitive function, neuropsychiatric symptoms, and postural control. In the future, rigorous-designed, high-quality RCTs with larger sample sizes are needed to further verify the effectiveness of VR therapy in the treatment of PD.
Evaluation of expert views and considerations to develop rehabilitation sports public services for persons with disabilities in Republic of Korea: a Delphi study
Authors: Park Jiyoung , Kang Dongheon , Eun Seon-Deok 
Published: March 2022

AbstractBackgroundPhysical activity is required to maintain health; however, resources needed for physical activity (e.g. facilities, instructors, and programmes) are scarce for persons with disabilities (PWD), particularly those who require rehabilitation following hospital discharge and those with severe disabilities. The Republic of Korea presently lacks a legal and administrative framework that supports the implementation of health services for PWD. Therefore, it is necessary to develop such a framework based on the perspectives of PWD, medical and physical education experts, facility managers, and government organisations. Thus, this study aimed to establish expert consensus on the development of rehabilitation sports public services (RSPS) in the Republic of Korea by reviewing previous studies and expert statements.MethodsUsing the Delphi method, we reviewed the literature to identify the critical roles and factors required for planning efficient RSPS programmes, including coordinators, physicians, facility managers, rehabilitation exercise and physical education instructors, and integrated information systems for facilities, instructors, and programmes. We developed a Delphi questionnaire with closed-ended questions, based on the factors derived from the literature review and supplementary open-ended questions, which was administered to a panel of 26 experts.ResultsThe panel reached a consensus on most factors (i.e. coordinators, physicians, facility managers, rehabilitation exercise and physical education instructors, and integrated information systems for facilities, instructors, and programmes). However, no consensus was reached regarding ‘when an applicant can continue/discontinue an RSPS programme’, ‘establishing information systems to manage physical fitness of PWD’, and ‘joint operation of the to-be-established system by the Ministry of Health and Welfare and Ministry of Culture, Sports, and Tourism’, leaving room for further debate.ConclusionsBy identifying the factors and roles necessary for RSPS, this study is expected to offer valuable information for state-led pilot projects and contribute to promoting physical activity and quality of life among PWD.
Effects of variable retention harvesting on canopy transpiration in a red pine plantation forest
Authors: Bodo Alanna V. , Arain M. Altaf 
Published: March 2022

Abstract
Background
Variable Retention Harvesting (VRH) is a forest management practice applied to enhance forest growth, improve biodiversity, preserve ecosystem function and provide economic revenue from harvested timber. There are many different forms and compositions in which VRH is applied in forest ecosystems. In this study, the impacts of four different VRH treatments on transpiration were evaluated in an 83-year-old red pine (Pinus Pinus resinosa) plantation forest in the Great Lakes region in Canada. These VRH treatments included 55% aggregated crown retention (55A), 55% dispersed crown retention (55D), 33% aggregated crown retention (33A), 33% dispersed crown retention (33D) and unharvested control (CN) plot. These VRH treatments were implemented in 1-ha plots in the winter of 2014, while sap flow measurements were conducted from 2018 to 2020.

Results
Study results showed that tree-level transpiration was highest among trees in the 55D treatment, followed by 33D, 55A, 33A and CN plots. We found that photosynthetically active radiation (PAR) and vapor pressure deficit (VPD) were major controls or drivers of transpiration in all VRH treatments. Our study suggests that dispersed or distributed retention of 55% basal area (55D) is the ideal forest management technique to enhance transpiration and forest growth.

Conclusions
This study will help researchers, forest managers and decision-makers to improve their understanding of water cycling in forest ecosystem and adopt the best forest management regimes to enhance forest growth, health and resiliency to climate change.
Homogeneous selection is not always important in bacterial community in the eutrophic enclosed bay
Authors: Zhu Junwei , Ma Yifan , Huang Lingfeng , Zhang Wenjing 
Published: March 2022

Abstract
Background
Previous studies have found that coastal eutrophication increases the influence of homogeneous selection on bacterial community assembly. However, whether seasonal changes affect the dominance of homogenous selection in bacterial community assembly in eutrophic bays remains unclear. Sansha Bay is an enclosed bay with ongoing eutrophication, located in the southeast coast of China. We investigated the bacterial community composition at two depths of the enclosed bay across seasons and the seasonal variation in community assembly processes.

Results
Diversity analyses revealed that the bacterial community composition among seasons differed significantly. By contrast, there was little difference in the community composition between the two depths. The temperature was the key environmental factor influencing the community composition. The null model indicated that the relative importance of homogeneous selection decreased in the following order: spring > winter > autumn > summer. Homogeneous selection did not always dominate the community assembly among seasons in the eutrophic bay. The effects of pure spatial variables on the community assembly were prominent in autumn and winter.

Conclusions
Our results showed the seasonal influence of eutrophication on bacterial community diversity. The seasonal variation in composition and structure of bacterial communities eclipsed the vertical variability. Eutrophication could enhance the importance of homogeneous selection in the assembly processes, but the seasonal environmental differences interfered with the steady-state maintained by ongoing eutrophication and changed the community assembly processes. Homogeneous selection was not always important in bacterial community in the eutrophic enclosed bay. The bacterial community was the most complex in summer, because the composition differed from other seasons, and the assembly process was the most intricate. These findings have contributed to understanding bacterial community composition and assembly processes in eutrophic coastal ecosystems.
Hand hygiene compliance and its drivers in long-term care facilities; observations and a survey
Authors: Haenen Anja , de Greeff Sabine , Voss Andreas , Liefers Janine , Hulscher Marlies , Huis Anita 
Published: March 2022

Abstract
Background
Hand hygiene is an important measure to prevent healthcare-associated infections in long-term care facilities.

Objectives
To evaluate compliance with hand hygiene recommendations by different nursing professionals in long-term care facilities and to investigate determinants potentially influencing hand hygiene and whether these differed between the different cadres of staff.

Methods
We conducted two sub-studies: we measured hand hygiene compliance of 496 professionals in 14 long-term care facilities (23 wards) through direct observation using World Health Organisation’s ‘five moments of hand hygiene’ observation tool. In addition, we performed a survey to examine determinants that may influence hand hygiene and to determine differences between different cadres of staff. We used a principal component analysis approach with varimax rotation to explore the underlying factor structure of the determinants.

Results
We found an overall mean hand hygiene compliance of 17%. There was considerable variation between wards (5–38%) and between specific World Health Organization hand hygiene moments. In addition, hand hygiene compliance varied widely within and between different cadres of staff. The determinant analysis was conducted on 177 questionnaires. For all nursing professionals, we found multiple determinants in four domains: ‘social context and leadership’, ‘resources’, ‘individual healthcare professional factors’ and ‘risk perception’. In two domains, several barriers were perceived differently by nursing assistants and nurses. In the domain ‘social context and leadership’, this included (1) how the manager addresses barriers to enable hand hygiene as recommended and (2) how the manager pays attention to correct adherence to the hand hygiene guidelines. In the ‘risk perception’ domain, this included a resident's risk of acquiring an infection as a result of the nursing professional’s failure to comply with the hand hygiene guidelines.

Conclusion
Hand hygiene compliance was low and influenced by multiple factors, several of which varied among different cadres of staff. When designing interventions to improve hand hygiene performance in long-term care facilities, strategies should take into account these determinants and how they vary between different cadres of staff. We recommend exploring hand hygiene determinants at ward level and among different cadres of staff, for example by using our exploratory questionnaire.

Trial registration
Registration number 50-53000-98-113, ‘Compliance with hand hygiene in nursing homes: go for a sustainable effect’ on ClinicalTrials.gov. Date of registration 28-6-2016.
Pre-endoscopy SARS-CoV-2 testing strategy during COVID-19 pandemic: the care must go on
Authors: Casper M. , Reichert M. C. , Rissland J. , Smola S. , Lammert F. , Krawczyk M. 
Published: March 2022

Abstract
Background
In response to the COVID-19 pandemic, endoscopic societies initially recommended reduction of endoscopic procedures. In particular non-urgent endoscopies should be postponed. However, this might lead to unnecessary delay in diagnosing gastrointestinal conditions.

Methods
Retrospectively we analysed the gastrointestinal endoscopies performed at the Central Endoscopy Unit of Saarland University Medical Center during seven weeks from 23 March to 10 May 2020 and present our real-world single-centre experience with an individualized rtPCR-based pre-endoscopy SARS-CoV-2 testing strategy. We also present our experience with this strategy in 2021.

Results
Altogether 359 gastrointestinal endoscopies were performed in the initial period. The testing strategy enabled us to conservatively handle endoscopy programme reduction (44% reduction as compared 2019) during the first wave of the COVID-19 pandemic. The results of COVID-19 rtPCR from nasopharyngeal swabs were available in 89% of patients prior to endoscopies. Apart from six patients with known COVID-19, all other tested patients were negative. The frequencies of endoscopic therapies and clinically significant findings did not differ between patients with or without SARS-CoV-2 tests. In 2021 we were able to unrestrictedly perform all requested endoscopic procedures (> 5000 procedures) by applying the rtPCR-based pre-endoscopy SARS-CoV-2 testing strategy, regardless of next waves of COVID-19. Only two out-patients (1893 out-patient procedures) were tested positive in the year 2021.

Conclusion
A structured pre-endoscopy SARS-CoV-2 testing strategy is feasible in the clinical routine of an endoscopy unit. rtPCR-based pre-endoscopy SARS-CoV-2 testing safely allowed unrestricted continuation of endoscopic procedures even in the presence of high incidence rates of COVID-19. Given the low frequency of positive tests, the absolute effect of pre-endoscopy testing on viral transmission may be low when FFP-2 masks are regularly used.
MaxEnt-based modeling of suitable habitat for rehabilitation of Podocarpus forest at landscape-scale
Authors: Tesfamariam Birhane Gebrehiwot , Gessesse Berhan , Melgani Farid 
Published: March 2022

AbstractModeling the current distribution and predicting suitable habitats of threatened species support proper planning processes for conservation and restoration. The aim of this study was thus to model the actual distribution and predict environmentally suitable habitats for Podocarpus falcatus, a locally threatened native tree species in Ethiopia. To realize this objective, species’ presence samples, BIOCLIMATIC, and topographic predictors were combined to run a MaxEnt model. Finally, a model-generated habitat suitability map was produced with AUC accuracy of 0.783. Among the variables used for modeling, elevation range was found to be a key predictor of Podocarpus distribution, followed by precipitation of the driest quarter and isothermality. An extensive area (> 48%) of the studied landscape has been predicted to be environmentally suitable for the target species. However, only a small portion open-land area is practically available for rehabilitation since the area has been intensively cultivated to support the densely inhabited population. Therefore, potential areas for a small-scale plantation of Podocarpus trees remain to be pocket sites in religious places and around farmers’ homesteads. So far, many farmers in this area have demonstrated a successful experience of growing this degraded native tree species. Thus, encouraging privately owned small-scale plantations could enhance rehabilitation and more sustainable conservation of the locally threatened native tree species.
Biosynthesis and bioactivities of metal nanoparticles mediated by Helichrysum aureonitens
Authors: Shelembe Bongisiwe , Mahlangeni Nomfundo , Moodley Roshila 
Published: March 2022

AbstractBiosynthesis of nanoparticles is the preferred route for the fabrication of biocompatible and cheaper drugs. In this study, the extract and major secondary metabolite from Helichrysum aureonitens, 3,5-dihydroxy-6,7,8-trimethoxyflavone, were used to synthesize silver and zinc oxide nanoparticles. Spectroscopic and microscopic techniques confirmed the formation of the nanoparticles. The flavone alone showed higher DPPH radical scavenging ability (IC50 = 487.1 μg mL−1) relative to the control, butylated hydroxytoluene. In addition, silver nanoparticles synthesized using the flavone had higher ferric reducing potential (Fe3+ to Fe2+) compared to the other test samples. The cytotoxic activity of the plant extract, the flavone, and their biosynthesized nanoparticles was also investigated using the MTT assay against the cancerous MCF-7 (breast adenocarcinoma) and A549 (human lung adenocarcinoma)), and non-cancerous HEK293 (human embryonic kidney) cell lines. The plant extract decreased the cell viability of A549 (IC50 = 68.6 μg mL−1) without being cytotoxic against HEK293, even at high concentrations. Silver nanoparticles significantly decreased cell viability of A549 and moderately decreased cell viability of MCF-7 but induced cell death of HEK293 even at low concentrations. This study provides a green synthesis route for silver and zinc oxide nanoparticles and confirms the therapeutic effectiveness of H. aureonitens, thereby validating its use in ethnomedicine.
A study to compare the efficacy of intrathecal dexmedetomidine versus nalbuphine as an adjuvant to 0.5% hyperbaric bupivacaine for postoperative analgesia in lower abdominal surgeries
Authors: Khare Arvind , Chohala Mukesh , Thada Beena , Mathur Veena , Garg Deepak , Tanwar Neha 
Published: March 2022

Abstract
Background
The subarachnoid block is a commonly used technique for lower abdominal surgeries. Bupivacaine being a cost-effective drug gives satisfactory analgesia for 90–120 min. Adjuvants such as dexmedetomidine and nalbuphine extend the analgesia in the postoperative period. In this study, we aimed to compare the effects of intrathecal dexmedetomidine and nalbuphine as an adjuvant to hyperbaric bupivacaine regarding the duration of analgesia as the primary objective and the time of onset of sensory and motor blockade, duration of motor blockade, haemodynamics parameters like mean heart rate and mean arterial blood pressure, and side effects if any being the secondary objectives. Eighty patients, aged 18–65 years of ASA physical status I and II, were randomly allocated into two groups. Group NB (n = 40) received 0.5% Inj. hyperbaric bupivacaine 18 mg (3.6 ml) + Inj.nalbuphine 1.0 mg (0.1 ml) while group DB (n = 40) received 0.5% Inj. hyperbaric bupivacaine 18 mg (3.6 ml) + Inj.dexmedetomidine 10 μg (0.1 ml).

Results
Patients in group DB had a significantly prolonged duration of analgesia as compared to group NB. The early onset of sensory and motor blockade was noted in group DB(P < 0.05). The duration of motor blockade was significantly prolonged in group DB (P < 0.05). Patients in both groups showed no significant difference in haemodynamic changes and incidence of side effects (P > 0.05).

Conclusions
Dexmedetomidine as an intrathecal adjuvant was found to have prolonged sensory and motor block and provide good quality of postoperative analgesia and stable haemodynamics with minimal side effects as compared to nalbuphine.