bluuebunny/crossref_metadata_2025_split huggingface dataset:
Funktionalisierte Faserkunststoffbewehrung zur Wärmespeicherung in Betonbauteilen
Authors: Gauer Tillman , Penkert Fabian , Pahn Matthias 
Published: May 2022

AbstractDurch die Vorgaben des Erneuerbare‐Energien‐Gesetzes wird Strom aus Erneuerbaren Energien vorrangig in das elektrische Netz eingespeist. Zur Vermeidung von Überlastungen im Stromnetz muss diese Einspeisung temporär reduziert werden. Die elektrische Energie, die in diesen Zeiträumen technisch erzeugt werden kann, aber nicht wird, wird als Ausfallarbeit bezeichnet. Diese fällt zum größten Teil in der Heizperiode an und kann zur Beheizung von Gebäuden genutzt werden. Ein Ansatz für die effiziente Einbindung von Erneuerbaren Energien eröffnet die Nutzung der Gebäudetragstruktur zur Wärmespeicherung. Im Rahmen dieses Beitrags wird eine Lösung vorgestellt, mit der elektrische Energie in Wärme umgewandelt, in Betonbauteilen gespeichert und zur Beheizung von Gebäuden genutzt wird. Die Einspeicherung von Wärme erfolgt über eine neuartige, funktionalisierte Faserkunststoffbewehrung mit einem Heizdraht in Querschnittsmitte. Um das Ziel der Reduktion von Ausfallarbeit zu erreichen, wird ein Modell benötigt, welches abhängig von der Beladedauer und der ‐spannung die Temperatur im Bauteil vorhersagt. Das mithilfe von Messungen entwickelte Modell erlaubt dies für Beladedauern bis zu 12 h. Zudem werden die im Bauteil gespeicherte Wärme sowie die resultierende Heizleistung prognostiziert. Im untersuchten Beispiel werden Leistungen von bis zu 174 W/m2 und Temperaturänderungsraten von rd. 1 K/h erreicht.
Phloretin‐induced cytoprotective effects on mammalian cells: A mechanistic view and future directions
Authors: de Oliveira Marcos Roberto 
Published: May 2022

AbstractPhloretin (C15H14O5), a dihydrochalcone flavonoid, is mainly found in fruit, leaves, and roots of apple tree. Phloretin exerts antioxidant, anti‐inflammatory, and anti‐tumor activities in mammalian cells through mechanisms that have been partially elucidated throughout the years. Phloretin bioavailability is well known in humans, but still remains to be better studied in experimental animals, such as mouse and rat. The focus of the present review is to gather information regarding the mechanisms involved in the phloretin‐elicited effects in different in vitro and in vivo experimental models. Several manuscripts were analyzed and data raised by authors were described and discussed here in a mechanistic manner. Comparisons between the effects elicited by phloretin and phloridzin were made whenever possible, as well as with other polyphenols, clarifying questions about the use of phloretin as a potential therapeutic agent. Toxicological aspects associated to phloretin exposure were also discussed here. Furthermore, a special section containing future directions was created as a suggestive guide towards the elucidation of phloretin‐related actions in mammalian cells and tissues. © 2016 BioFactors, 42(1):13–40, 2016
Labyrinthitis ossificans following severe acute otitis media
Authors: Uraguchi Kensuke , Kariya Shin , Ando Mizuo 
Published: May 2022

AbstractLabyrinthitis occurs because of the inflammation of the inner ear. We present a rare case of labyrinthitis ossificans following an acute otitis media. The T2‐weighted magnetic resonance imaging showed decreased signal intensity in the right inner ear due to labyrinthitis ossificans, consistent with the clinical presentation.
The earlier, the better? A review of neoadjuvant immunotherapy in resectable non‐small‐cell lung cancer
Authors: Li Fajiu , Chen Ying , Wu Juanjuan , Li Chenghong , Chen Shi , Zhu Ziyang , Qin Wei , Liu Min , Hu Bingzhu , Liu Shuang , Zhong Wenzhao 
Published: May 2022

AbstractImmune checkpoint inhibitors (ICIs) have revolutionized the approach to advanced and locally advanced non‐small‐cell lung cancer (NSCLC). Antibodies blocking inhibitory immune checkpoints, such as programmed death 1 (PD‐1) and its ligand (PD‐L1), have remarkable antitumor efficacy and have been approved as a standard first‐ or second‐line treatment in non‐oncogene‐addicted advanced NSCLC. The successful application of immunotherapy in advanced lung cancer has motivated researchers to further evaluate its clinical role as a neoadjuvant setting for resectable NSCLC and for improved long‐term overall survival and curative rates. In this review, we discuss the efforts that incorporate ICIs into the treatment paradigm for surgically resectable lung cancer. We reviewed the early‐phase results from neoadjuvant clinical trials, the landscape of the majority of ongoing phase III trials, and discuss the prospects of ICIs as a curative therapy for resectable lung cancer. We also summarized the potential biomarkers and beneficiaries involved in the current study, as well as the remaining unresolved challenges for neoadjuvant immunotherapy.
CaO‐Based Heterogeneous Catalyst from Cow Bone for Direct Cracking of Triglycerides
Authors: Ameh Charles Ugbede , Eterigho Elizabeth Jumoke , Musa Abdullahi Abdullahi 
Published: May 2022

AbstractA calcium oxide (CaO)‐based heterogeneous catalyst derived from waste cow bone for the direct cracking of Moringa oleifera seed oil was investigated. Optimization was carried out using a five‐level‐four‐factorial central composite design based on response surface methodology in 30 experimental runs. Under the optimal conditions of reaction temperature, catalyst concentration, reaction time, and agitation speed, 68 % biodiesel was achieved. A total of four major fatty acid methyl esters were identified in the synthesized biodiesel by the retention time and fragmentation pattern data of the gas chromatography‐mass spectrometry analysis. The statistical model for predicting the biodiesel yield was developed for the effects and percentage contributions of the optimization variables.
N‐CF3 Imidazolidin‐2‐one Derivatives via Photocatalytic and Silver‐Catalyzed Cyclizations
Authors: Turksoy Abdurrahman , Bouayad‐Gervais Samir , Schoenebeck Franziska 
Published: May 2022

AbstractWhile the N‐trifluoromethylation of cyclic ureas is of interest for the potential to fundamentally change the properties of these biologically relevant moieties, the single synthetic procedure known to date describing their access only gives 4,4‐disubstituted or fused aromatic cyclic N‐CF3 urea derivatives. We herein report an alternative approach to unleash access to the 4‐monosubstituted imidazolidinone motif. The strategy relies on straightforward cyclization of readily accessible acyclic ureas, enabled by Ag‐catalysis or light‐assisted proton coupled electron transfer. The cyclic core is shown to be highly robust and amenable to various derivatizations, such as tandem Ni‐catalysis, C−B, C−N, C−C cross couplings or C−H functionalizations, tolerating basic, nucleophilic and/or oxidizing conditions.
Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety
Authors: Kondej Magda , Wróbel Tomasz M. , Targowska‐Duda Katarzyna M. , Leandro Martínez Antón , Koszła Oliwia , Stępnicki Piotr , Zięba Agata , Paz Alba , Wronikowska‐Denysiuk Olga , Loza Maria I. , Castro Marián , Kaczor Agnieszka A. 
Published: May 2022

AbstractSchizophrenia is a complex disease which is best treated with multitarget drugs, such as atypical antipsychotics. Previously, using structure‐based virtual screening, we found a virtual hit, D2AAK1, with nanomolar affinity for dopamine and serotonin receptors important in schizophrenia pharmacotherapy. As a part of an optimization campaign of D2AAK1, we obtained 17 derivatives that also display a multitarget profile. Selected compounds were tested against off‐targets in schizophrenia, i. e., histamine H1receptor and muscarinic M1receptor, and these did not display considerable affinity for these receptors. The two most promising compounds were subjected to behavioral studies. These compounds decreased amphetamine‐induced hyperactivity in mice which indicates their antipsychotic potential. The compounds did not interfere with the memory consolidation in mice, as determined in the passive avoidance test. The favorable pharmacological profile of these compounds was rationalized using molecular modeling.
An innovative framework for balanced cluster‐based data aggregation in sensor networks
Authors: Jain Khushboo , Kumar Anoop 
Published: May 2022

SummaryThe essential design concern of a sensor network is to balance energy consumption of sensor nodes (SNs) to prolong the network lifetime. Many research works cited that clustering techniques efficiently utilize the network's energy resource by organizing SNS into groups of clusters and benefits in reduced data transmission. An extensively used category of cluster‐based protocols is the probabilistic clustering technique in which a preset optimum likelihood is used to facilitate the selection procedure of cluster head (CH). These clustering techniques suffer from non‐uniform dissemination of CH, which leads to uneven load balance and uneven energy consumption of SNs during network activities like data transmitting and data receiving. This causes an energy‐hole problem and reduces network lifetime. In order to solve these issues, we have focused on to design a balanced cluster‐based data aggregation and formulate a method that increases the energy efficiency of probabilistic clustering techniques by optimizing the number of clusters and the dissemination of CHs in the sensor network. The simulation analysis proves that the proposed technique accomplishes significantly enhanced than the existing works.
Regulation of homeostasis and regeneration in the adult intestinal epithelium by the TGF‐β superfamily
Authors: Fink Mardi , Wrana Jeffrey L. 
Published: May 2022

AbstractThe delicate balance between the homeostatic maintenance and regenerative capacity of the intestine makes this a fascinating tissue of study. The intestinal epithelium undergoes continuous homeostatic renewal but is also exposed to a diverse array of stresses that can range from physiological processes such as digestion to exposure to infectious agents, drugs, radiation therapy, and inflammatory stimuli. The intestinal epithelium has thus evolved to efficiently maintain and reinstate proper barrier function that is essential for intestinal integrity and function. Factors governing homeostatic epithelial turnover are well described; however, the dynamic regenerative mechanisms that occur following injury are the subject of intense ongoing investigations. The TGF‐β superfamily is a key regulator of both homeostatic renewal and regenerative processes of the intestine. Here, we review the roles of TGF‐β and BMP on the adult intestinal epithelium during self‐renewal and injury to provide a framework for understanding how this major family of morphogens can tip the scale between intestinal health and disease.
Pteridophyte species richness in the central Himalaya is limited by cold climate extremes at high elevations and rainfall seasonality at low elevations
Authors: Qian Hong , Kessler Michael , Vetaas Ole R. 
Published: May 2022

AbstractThere is a consensus that climate factors strongly influence species richness along elevation gradients, but which factors are crucial and how they operate are still elusive. Here, we assess the relative importance of temperature‐related versus precipitation‐related variables and the relative importance of extreme climate versus climate seasonality in driving pteridophyte species richness. We used correlation and regression analyses to relate species richness of pteridophytes, and their two major groups (lycophytes, ferns), in fifty 100‐m vertical bands to climatic factors representing different aspects of climatic conditions (general climate, stressful climate, and climate seasonality). Variation partitioning analysis was used to determine the relative importance of each group of climatic factors on species richness. Across the entire elevational gradient, species richness had a parabolic response to mean annual temperature (adjusted R2 = .87−.91), and a linear response to annual precipitation (adjusted R2 = .82). Mean annual temperature and annual precipitation in the second‐order polynomial model together explained 96.3%−98.7% of the variation in species richness. The variation in species richness uniquely explained by minimum temperature of the coldest month was much greater than that uniquely explained by temperature seasonality, but the variation in species richness uniquely explained by precipitation during the driest month was much smaller than that uniquely explained by precipitation seasonality. Overall, extreme climate variables explained slightly more variation than did climate seasonality. Our study suggests that pteridophyte richness along the elevational gradient is largely driven by a combination of both temperature‐ and precipitation‐related parameters, although precipitation‐related variables play a slightly stronger role, and that extreme low temperature events (at high elevations) and seasonal precipitation variability (at low elevations) are the strongest determinants of pteridophyte species richness.
Sensitive environmental DNA (eDNA) methods to detect hemlock woolly adelgid and its biological control predators Leucotaraxis silver flies and a Laricobius beetle
Authors: Kirtane Anish , Dietschler Nicholas J. , Bittner Tonya D. , Lefebvre Marshall Bigler , Celis Sabrina , O'Connor Katharine , Havill Nathan , Whitmore Mark C. 
Published: May 2022

AbstractEnvironmental DNA (eDNA) analysis can be a powerful tool for the early detection of invasive organisms. However, research on terrestrial eDNA detection from foliage surfaces has been limited. In this study, we developed methods to capture and detect eDNA using qPCR from an invasive forest pest, hemlock woolly adelgid (Adelges tsugae), and three of its biological control predators Leucotaraxis piniperda, Leucotaraxis argenticollis, and Laricobius nigrinus. We designed four highly efficient qPCR assays with a low limit of detection (1–10 copies/reaction). The assay targeting A. tsugae was species‐specific. The assays targeting Le. piniperda, and Le. argenticollis were biotype‐specific in addition to being species‐specific demonstrating applications of eDNA analysis beyond species‐level detection. The La. nigrinus assay also detected DNA from closely related and hybridizing Laricobius rubidus. The eDNA methods were evaluated against traditional detection methods. We collected foliage samples from three strata (bottom, middle, and top) of eastern hemlock trees to detect the presence of A. tsugae. The detection of the biological control predators was evaluated using western hemlock foliage samples collected from the predators' native range in western Washington. The eDNA methods had significantly higher positive detection rates (2.8–4.5 times) than conventional methods of all target species. The strata of sampling were not significant in determining the presence of A. tsugae infestation. The eDNA concentration positively correlated with the observed density for all species. This study demonstrates the efficacy of eDNA analysis as a more sensitive tool for early detection of A. tsugae and to track the establishment of its biological control predators.
Association between central haemodynamics and renal function in advanced heart failure: a nationwide study from Sweden
Authors: Bobbio Emanuele , Bollano Entela , Polte Christian L. , Ekelund Jan , Rådegran Göran , Lundgren Jakob , Haggård Carl , Gjesdal Grunde , Braun Oscar , Bartfay Sven‐Erik , Bergh Niklas , Dahlberg Pia , Hjalmarsson Clara , Esmaily Sorosh , Haugen Löfman Ida , Manouras Aristomenis , Melin Michael , Dellgren Göran , Karason Kristjan 
Published: May 2022

AbstractAimsRenal dysfunction in patients with heart failure (HF) has traditionally been attributed to declining cardiac output and renal hypoperfusion. However, other central haemodynamic aberrations may contribute to impaired kidney function. This study assessed the relationship between invasive central haemodynamic measurements from right‐heart catheterizations and measured glomerular filtration rate (mGFR) in advanced HF.Methods and resultsAll patients referred for heart transplantation work‐up in Sweden between 1988 and 2019 were identified through the Scandiatransplant organ‐exchange organization database. Invasive haemodynamic variables and mGFR were retrieved retrospectively. A total of 1001 subjects (49 ± 13 years; 24% female) were eligible for the study. Analysis of covariance adjusted for age, sex, and centre revealed that higher right atrial pressure (RAP) displayed the strongest relationship with impaired GFR [β coefficient −0.59; 95% confidence interval (CI) –0.69 to −0.48; P < 0.001], followed by lower mean arterial pressure (MAP) (β coefficient 0.29; 95% CI 0.14–0.37; P < 0.001), and finally reduced cardiac index (β coefficient 3.51; 95% CI 2.14–4.84; P < 0.003). A combination of high RAP and low MAP was associated with markedly worse mGFR than any other RAP/MAP profile, and high renal perfusion pressure (RPP, MAP minus RAP) was associated with superior renal function irrespective of the degree of cardiac output.ConclusionsIn patients with advanced HF, high RAP contributed more to impaired GFR than low MAP. A higher RPP was more closely related to GFR than was high cardiac index.
Multicomponent directional‐cum‐modal combination rule for seismic analysis: Theory and illustrations
Authors: Basu Dhiman , Vats Falak , Panchal Aniket 
Published: May 2022

AbstractSince spectral representation of ground motion can capture the epistemic uncertainty and aleatory variability better than time series representation, direction‐cum‐modal combination rule plays the pivotal rule when incorporating the multicomponent excitations in seismic design and in assessing the seismic resilience. CQC is generally believed to be the best modal combination rule for unidirectional seismic excitation, but the directional combination rule is still at its infancy when six‐component seismic excitations are considered. Though a few extensions have been reported to account for more than one component, six‐component directional combination rule is still an open call. Directional‐cum‐modal combination rule is developed in this paper from the first principle to combine the modal responses of a structure subjected to six‐component ground motion with spectral representation as the 5% damped acceleration response spectra. In addition, the framework requires the power spectral shape of each component of excitations, directional correlation function for each pair of excitations, and duration of the event. With linear time history analysis as the benchmark, the proposed combination rule is compared against CQC as the modal combination rule with SRSS for the directional combination. Two numerical examples are presented including a 30‐storied building to emphasize the role of rotational (rocking) components. The proposed combination rule works much better if the recorded components of ground motion are used for structural analysis. However, the difference reduces if the recorded components of ground motion are rotated along‐and‐normal to the principal plane prior to analysis. This is verified against several suites of recorded ground motion.
Evaluation of electricity generation on GeSn single‐junction solar cell
Authors: Zhu Xinmiao , Cui Min , Wang Yu , Yu Tianjing , Li Qianying , Deng Jinxiang , Gao HongLi 
Published: May 2022

SummaryElectricity generation of GeSn single‐junction solar cell has been carefully examined in both its p‐on‐n and n‐on‐p configurations in its normal and inverted structures. The superior p+/n construction with a critical doping of the light‐doped layer (Nd = 7.5 × 1018 cm−3) has been observed. For the normal one, the active layer should be composed of 50‐100 nm emitter and 3‐5 μm base to less material costs. Moreover, dislocation density and 1 MeV electron fluence should be lower than 1 × 105 cm−2 and 1 × 1010 cm−2, respectively, which is helpful for obtaining a preferable conversion efficiency. To explore lower cost solar cell, the simulated results might be favorable to guide experimental fabrication of GeSn devices.
Thermodynamic analysis of a hybrid cogeneration energy system based on compressed air energy storage with high temperature thermal energy storage and supercritical CO2 Brayton cycle
Authors: Cao Ruifeng , Ni Hexi , Wang Yufei , Duan Yanfeng 
Published: May 2022

SummaryThe large‐scale penetration of renewable energy leads to some imperative issues to the power grid. Energy storage technology is regarded as an effective method to solve these problems. In this paper, a hybrid cogeneration energy system based on compressed air energy storage system with high temperature thermal energy storage and supercritical CO2 Brayton cycle is proposed. A thermodynamic model of the system is established. Energy and exergy analysis are carried out based on a case study. It was found that under the design condition, the round trip efficiency of 58.66%, the energy storage density of 5.45 kWh/m3, and the overall exergy efficiency of 62.00% can be achieved. At the same time, the hot water about 88°C can be supplied. The influences of some key parameters on the performance are analyzed. It was found that the round trip efficiency is most sensitive to the outlet temperature of high temperature thermal energy storage system, isentropic efficiency of compressors and turbines, followed by the intercoolers effectiveness.
Capsule‐shaped calcium and cobalt‐doped ZnO electrodes for high electrochemical supercapacitor performance
Authors: Nallapureddy Ramesh Reddy , Pallavolu Mohan Reddy , B Hemanth Kumar , Gutturu Rajasekhara Reddy , Merum Dhananjaya , Yedluri Anil Kumar , Joo Sang Woo 
Published: May 2022

SummaryMetal co‐doping of metal oxide nanostructures is a promising approach for enhancing the electrochemical performance of supercapacitors. Herein, calcium (Ca) and cobalt (Co) co‐doped ZnO capsules (Ca‐Co@ZnO) were fabricated using a facile and single‐step hydrothermal process. The physical, chemical, and morphological properties of the Ca‐Co@ZnO were analyzed using a range of characterization techniques such as X‐ray diffraction, X‐ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy. Ca‐Co@ZnO showed a remarkable supercapacitor performance in a 3 M KOH aqueous electrolyte. The specific capacitance was 1020 F/g at a current density of 0.75 A/g, which was 3.2, 1.7, and 1.6 times higher than the pristine ZnO, Ca‐ZnO, and Co‐ZnO capsules, respectively. Ca‐Co@ZnO showed more than 50% capacity retention at a higher current density and strong cycling stability up to 5000 cycles with only 8% capacity loss. The Ca‐Co@ZnO//Ca‐Co@ZnO symmetric performance was also investigated. This device showed a specific capacitance of 187 F/g at a current density of 1 A/g and an energy density of 25.9 Wh/kg at a power density of 556.6 W/kg. The superior performance was attributed to the fast electron accessibility, strong ion diffusion, and higher active sites. Overall, the superior electrochemical performance and novel structures could be beneficial for developing metal co‐doped metal oxide electrodes for supercapacitor applications.