bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid Metabolic Genes and Maternal Supraphysiological Hypercholesterolemia: An Analysis of Maternal-fetal Interaction
Authors: Cai Xiaxia , Liang Ning , Cai Xueping , Zhou Qi , Dang Qinyu , Hu Zhuo , Yu Huanling 
Published: May 2022

Abstract

Context
The joint associations of maternal and fetal single nucleotide polymorphisms (SNPs) of lipid metabolic genes with the risk of maternal supraphysiological hypercholesterolemia (MSPH) are unclear.

Objective
This study aims to investigate the associations of maternal/fetal SNPs of APOE, LPL, LDLR, PCSK9, and SCARB1 with the risk of MSPH and explore whether the maternal-fetal pairing pattern of the risk alleles can affect MSPH risk.

Methods
A nested case-control study was conducted that included 182 pregnant women with MSPH and 182 with maternal physiological hypercholesterolemia. Maternal venous and umbilical venous blood were collected to detect the SNPs of genes. The primary outcome was MSPH. Logistic regression model was used to determine the associations of SNPs with risk of MSPH.

Results
The C-allele in maternal APOE rs429358 T &gt; C (adjusted odds ratio [OR] = 1.72, P = 0.033), G-allele in fetal APOE rs440446 C &gt; G (adjusted OR = 1.62, P = 0.012) and T-allele in fetal LPL rs263 C &gt; T (adjusted OR = 1.53, P = 0.011) increased the risk of MSPH. The A-allele in maternal LDLR rs7258950 G &gt; A decreased the risk of MSPH (adjusted OR = 0.67, P = 0.028). For maternal-fetal pairing analysis, the variant concordance of PCSK9 rs2149041, rs7523141, rs7523242, rs7525649, and LDLR rs7258950 were associated with the decreased risk of MSPH under the dominant model. The variant concordance of other SNPs of PCSK9, APOE, LDLR, LPL, and SCARB1 were associated with the increased risk of MSPH.

Conclusion
This study supports the hypothesis that maternal and fetal genetic polymorphisms of lipid metabolic genes are associated with the risk of MSPH. The maternal-fetal variant concordance is also associated with this risk.
Order beyond Equilibrium: Ludwig Lachmann's Bridging of Seemingly Irreconcilable Traditions
Authors: Fritz Roland , Novak Rok 
Published: May 2022

Abstract
Throughout his career, Ludwig M. Lachmann theorized about how economies and societies achieve order in an uncertain world full of heterogeneous agents, heterogeneous production factors, and multilayered subjectivity. This article traces how he began his research agenda by expanding the conventional equilibrium framework of the 1930s to include (potentially diverging) expectations but gradually abandoned price coordination as the sole source of order in an economy. Instead, he set out to formulate an institutional theory of socially embedded plan coordination, which transcended the traditional division between commerce and community. This article illustrates this shift in Lachmann's focus by using two of his neglected German publications. Additionally, it lays out how Lachmann's effort in the “thinking in orders” tradition was principally rooted in his dissatisfaction with approaches to economics that reduced it to a “pure logic of choice.” Lachmann instead conceived of his discipline as being something closer to Max Weber's “socioeconomics,” and in this he was strongly influenced by the German historical school. This article explains how, ironically, this tradition, which historically positioned itself in stark opposition to the Austrian school, has—through the mediation of Lachmann—had considerable influence on the recent history of the Austrian school in the United States.
Transatlantic Roads to Mont Pèlerin: “Old Chicago” and Freiburg in a World of Disintegrating Orders
Authors: Kolev Stefan , Köhler Ekkehard A. 
Published: May 2022

AbstractThis article depicts the parallel evolution of the political economies of the “Old Chicago” and Freiburg schools. Both communities within the “laissez-faire within rules” research program and the long-standing “thinking in orders” tradition emerged during the 1930s and culminated in the 1940s, crystallizing around the personalities of Henry C. Simons and Walter Eucken. We show how, in an age of disintegration of national and international orders of economy and society, the political economists at Chicago and Freiburg underwent a double transition: from students of equilibrium to students of order, and from students of various positive orders to defenders of a specific normative order. The vision of the normative order on both sides of the Atlantic was the competitive order and its rules-based framework. Along with shared angst amid disintegrating orders, personal transatlantic connections between the two communities are identified, starting in Berlin during the 1920s. This article highlights the role of Friedrich A. Lutz, who, from the mid-1930s to Eucken's death and beyond, served as a lifeline between the isolated Freiburg school and Anglo-Saxon economists. Lutz's activities are embedded in a narrative of transatlantic conversations around Friedrich A. Hayek and the early meetings of the Mont Pèlerin Society.
Teaching Life Writing as Civic Education
Authors: Blumberg Ilana M. 
Published: May 2022

AbstractFocusing on a course taught to Palestinian and Jewish Israelis, this essay suggests that the study of life writing can help students develop a better informed civic identity, particularly in relation to divisive national matters. By carefully constructing collective classroom practices of reading, writing, discussing, and listening, the instructor can forge an environment that strengthens students’ capacity to appreciate the textual and contemporary interaction between individuals and their historical contexts, and to hear alternative perspectives and experiences attentively, without argument. University classrooms can thus play a vital role in democratic culture, as spaces in which a broader range of voices can be heard and in which minority voices are specially protected and projected.
Thinking inside the Panel
Authors: Laflen Angela , Fitzgibbons Moira 
Published: May 2022

Abstract
This article discusses how we have used undergraduate research (UR) to foster habits of mind associated with information literacy (IL). Our strategy is course based and involves students as potential contributors to the Graphic Narrative Database (GND), a digital work in progress. Presenting students with focused parameters for their research and with the prospect of an authentic audience for their writing, the assignment provides students with many opportunities to explore our complex information landscape as practitioners. Students deploy a wide array of strategies to gather and share information about a body of texts that are themselves richly multimodal.
Trends in bacteriological spectrum and antibiotic susceptibility on blood culture in pediatric cardiac patients at a tertiary childcare health facility
Authors: Adnan Mudasser , Arshad Muhammad Sohail , Haq Hafiz Anwar-ul , Raza Hashim 
Published: May 2022

Objectives: To report trends in bacteriological spectrum and antibiotic susceptibility on blood culture in admitted pediatric cardiac patients at a Tertiary Childcare Health Facility.
Methods: This cross-sectional observational study was conducted at the Department of Pediatric Cardiology, The Children’s Hospital and Institute of Child Health, Multan from January 2018 to December 2020. We included admitted children of both genders aged one day to 12 years and whose blood sample was sent for blood culture analysis. Gram staining was used to identify isolated organisms. Distribution of types of strains, bacterial isolates and antimicrobial sensitivity/resistance were recorded.
Results: During the study period, a total of 772 blood samples were sent for blood culture analysis, out of which, 154 (19.9%) turned out to be positive. Mean age was noted to be 1.12±2.3 years. Gram negative rods were the most frequently noted strains found among 69 (44.8%) cases. A total of 131 strains were found to have bacterial isolates. Salmonella typhi was the commonest bacterial agent noted in 30 (19.4%) cases while Coagulase Negative Staphylococcus in 18 (11.7%) and acinetobacter baumannii in 16 (10.4%).
Conclusion: Blood culture positivity rate was found to be 19.9%. Gram negative rods were the most frequently noted strains. Salmonella typhi, Coagulase Negative Staphylococcus and Acinetobacter baumannii were found to be the commonest bacterial isolates responsible. Routinely used antibiotics like Ciprofloxacin, Cefotaxime, Ceftizadime and Ampicillin were found to have high rates of resistance against most commonly found bacterial isolates.
doi: https://doi.org/10.12669/pjms.38.5.5072
How to cite this:Adnan M, Arshad MS, Anwar-ul-Haq H, Raza H. Trends in bacteriological spectrum and antibiotic susceptibility on blood culture in pediatric cardiac patients at a tertiary childcare health facility. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5072
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The outcome of gynecologic cancer patients with Covid-19 infection: A systematic review and meta-analysis
Authors: Winata I Gde Sastra , Simatupang Januar , Polim Arie A , Togar Yakob , Tondang Advenny Elisabeth 
Published: May 2022

Background: Cancer is a comorbidity that leads to progressive worsening of coronavirus disease 2019 (Covid-19) with increased mortality. This is a systematic review and meta-analysis to yield evidence of adverse outcomes of Covid-19 in gynecologic cancer. Methods: Searches through PubMed, Google Scholar, ScienceDirect, and medRxiv to find articles on the outcome of gynecologic cancer with Covid-19 (24 July 2021–19 February 2022). The Newcastle-Ottawa Scale tool was used to evaluate the quality of included studies. Pooled odds ratio (OR), 95% confidence interval (CI) and random-effects model were presented. Results: We accepted 51 studies (a total of 1991 gynecologic cancer patients with Covid-19). Covid-19 infection cases were lower in gynecologic cancer vs hematologic cancer (OR 0.71, CI 0.56-0.90, p 0.005). Severe Covid-19 infection and death were lower in gynecologic cancer vs lung and hematologic cancer (OR 0.36, CI 0.16-0.80, p 0.01), (OR 0.52, CI 0.44-0.62, p <0.0001), (OR 0.26, CI 0.10-0.67 p 0.005), (OR 0.63, CI 0.47-0.83, p 0.001) respectively. Increased Covid death was seen in gynecologic cancer vs population with breast cancer, non-Covid cancer, and non-cancer Covid (OR 1.50, CI 1.20-1.88, p 0.0004), (OR 11.83, CI 8.20-17.07, p <0.0001), (OR 2.98, CI 2.23-3.98, p <0.0001) respectively. Conclusion: Gynecologic cancer has higher Covid-19 adverse outcomes compared to non-cancer, breast cancer, non-metastatic, and Covid-19 negative population. Gynecologic cancer has fewer Covid-19 adverse outcomes compared to other cancer types, lung cancer, and hematologic cancer. These findings may aid health policies and services during the ongoing global pandemic. PROSPERO Registration: CRD42021256557 (22/05/21)
Development and feasibility testing of action observation training videos in acute stroke survivors
Authors: Biswas Arunima , Natarajan Manikandan , Subramanian Sandeep K , Solomon John M. 
Published: May 2022

Background: Action observation training (AOT) is used for lower limb (LL) stroke rehabilitation in subacute and chronic stages, but concise information regarding the types of activities to be used and the feasibility of administration in the acute stroke population is unknown. The aim of this study was to develop and validate videos of appropriate activities for LL AOT and test administrative feasibility in acute stroke. Method: A video inventory of LL activities was created after a literature survey and expert scrutiny. Five stroke rehabilitation experts validated the videos per domains of relevance, comprehension, clarity, camera position and brightness. LL AOT was then tested on ten individuals with acute stroke for uncovering barriers for clinical use in a feasibility study. Participants watched the activities and attempted imitation of the same. Determination of administrative feasibility was undertaken via participant interviews. Results: Suitable LL activities for stroke rehabilitation were identified. Content validation of videos led to improvements in selected activities and video quality. Expert scrutiny led to further video processing to include different perspectives of view and speeds of projected movements. Barriers identified included inability to imitate actions shown in videos and increased distractibility for some participants. Conclusion: A video catalogue of LL activities was developed and validated. AOT was deemed safe and feasible for acute stroke rehabilitation and may be used in future research and clinical practice.
Doublet identification in single-cell sequencing data using scDblFinder
Authors: Germain Pierre-Luc , Lun Aaron , Garcia Meixide Carlos , Macnair Will , Robinson Mark D. 
Published: May 2022

Doublets are prevalent in single-cell sequencing data and can lead to artifactual findings. A number of strategies have therefore been proposed to detect them. Building on the strengths of existing approaches, we developed scDblFinder, a fast, flexible and accurate Bioconductor-based doublet detection method. Here we present the method, justify its design choices, demonstrate its performance on both single-cell RNA and accessibility (ATAC) sequencing data, and provide some observations on doublet formation, detection, and enrichment analysis. Even in complex datasets, scDblFinder can accurately identify most heterotypic doublets, and was already found by an independent benchmark to outcompete alternatives.
ECORISK2050: An Innovative Training Network for predicting the effects of global change on the emission, fate, effects, and risks of chemicals in aquatic ecosystems
Authors: Welch Samuel A. , Lane Taylor , Desrousseaux Alizée O.S , van Dijk Joanke , Mangold-Döring Annika , Gajraj Rudrani , Hader John D. , Hermann Markus , Parvathi Ayillyath Kutteyeri Anju , Mentzel Sophie , Nagesh Poornima , Polazzo Francesco , Roth Sabrina K. , Boxall Alistair B.A. , Chefetz Benny , Dekker Stefan C. , Eitzinger Josef , Grung Merete , MacLeod Matthew , Moe S. Jannicke , Rico Andreu , Sobek Anna , van Wezel Annemarie P. , van den Brink Paul 
Published: May 2022

By 2050, the global population is predicted to reach nine billion, with almost three quarters living in cities. The road to 2050 will be marked by changes in land use, climate, and the management of water and food across the world. These global changes (GCs) will likely affect the emissions, transport, and fate of chemicals, and thus the exposure of the natural environment to chemicals. ECORISK2050 is a Marie Skłodowska-Curie Innovative Training Network that brings together an interdisciplinary consortium of academic, industry and governmental partners to deliver a new generation of scientists, with the skills required to study and manage the effects of GCs on chemical risks to the aquatic environment. The research and training goals are to: (1) assess how inputs and behaviour of chemicals from agriculture and urban environments are affected by different environmental conditions, and how different GC scenarios will drive changes in chemical risks to human and ecosystem health; (2) identify short-to-medium term adaptation and mitigation strategies, to abate unacceptable increases to risks, and (3) develop tools for use by industry and policymakers for the assessment and management of the impacts of GC-related drivers on chemical risks. This project will deliver the next generation of scientists, consultants, and industry and governmental decision-makers who have the knowledge and skillsets required to address the changing pressures associated with chemicals emitted by agricultural and urban activities, on aquatic systems on the path to 2050 and beyond.
African swine fever variants currently outside Africa
Authors: Carr John , Howells Mark , Hersey William 
Published: May 2022

In 2007 African swine fever (ASF) type 2 entered Georgia and since then has progressively moved around the planet resulting in a global pandemic, which is responsible for killing many millions of pigs. Local spread occurs through wild pig movement but human movement of pork products and even pigs for hunting has resulted in movement over 1000s of kilometres. With the devastating impact of ASF type 2 on a pig farm the development of a suitable vaccine is essential. Unfortunately, in desperation, potential ASF vaccine candidates have been released. The premature release of vaccine candidates has created clinical confusion by reducing the clinical signs of ASF, in particular the high pyrexia usually seen in pigs infected with this virus. The lack of specific clinical signs can make identify of sick animals more difficult and this increases the potential for incursion across national borders.
A molecular view of amyotrophic lateral sclerosis through the lens of interaction network modules
Authors: Jensen Klaus Højgaard , Stalder Anna Katharina , Wernersson Rasmus , Roloff-Handschin Tim-Christoph , Hansen Daniel Hvidberg , Groenen Peter M. A. 
Published: May 2022

Background
Despite the discovery of familial cases with mutations in Cu/Zn-superoxide dismutase (SOD1), Guanine nucleotide exchange C9orf72, TAR DNA-binding protein 43 (TARDBP) and RNA-binding protein FUS as well as a number of other genes linked to Amyotrophic Lateral Sclerosis (ALS), the etiology and molecular pathogenesis of this devastating disease is still not understood. As proteins do not act alone, conducting an analysis of ALS at the system level may provide new insights into the molecular biology of ALS and put it into relationship to other neurological diseases.

Methods
A set of ALS-associated genes/proteins were collected from publicly available databases and text mining of scientific literature. We used these as seed proteins to build protein-protein interaction (PPI) networks serving as a scaffold for further analyses. From the collection of networks, a set of core modules enriched in seed proteins were identified. The molecular biology of the core modules was investigated, as were their associations to other diseases. To assess the core modules’ ability to describe unknown or less well-studied ALS biology, they were queried for proteins more recently associated to ALS and not involved in the primary analysis.

Results
We describe a set of 26 ALS core modules enriched in ALS-associated proteins. We show that these ALS core modules not only capture most of the current knowledge about ALS, but they also allow us to suggest biological interdependencies. In addition, new associations of ALS networks with other neurodegenerative diseases, e.g. Alzheimer’s, Huntington’s and Parkinson’s disease were found. A follow-up analysis of 140 ALS-associated proteins identified since 2014 reveals a significant overrepresentation of new ALS proteins in these 26 disease modules.

Conclusions
Using protein-protein interaction networks offers a relevant approach for broadening the understanding of the biological context of known ALS-associated genes. Using a bottom-up approach for the analysis of protein-protein interaction networks is a useful method to avoid bias caused by over-connected proteins. Our ALS-enriched modules cover most known biological functions associated with ALS. The presence of recently identified ALS-associated proteins in the core modules highlights the potential for using these as a scaffold for identification of novel ALS disease mechanisms.
Simultaneous validation of wearable motion capture system for lower body applications: over single plane range of motion (ROM) and gait activities
Authors: Mihcin Senay 
Published: May 2022

Abstract
Extracting data from {Zhu, 2019 #5} daily life activities is important in biomechanical applications to define exact boundary conditions for the intended use-based applications. Although optoelectronic camera-marker based systems are used as gold standard tools for medical applications, due to line-of-sight problem, there is a need for wearable, affordable motion capture (MOCAP) systems. We investigate the potential use of a wearable inertial measurement unit (IMU) based-wearable MOCAP system for biomechanical applications. The in vitro proof of concept is provided for the full lower body consisting of hip, knee, and ankle joints via controlled single-plane anatomical range of motion (ROM) simulations using an electrical motor, while collecting data simultaneously via opto-electronic markers and IMU sensors. On 15 healthy volunteers the flexion-extension, abduction-adduction, internal-external rotation (ROM) values of hip and, the flexion – extension ROM values of the knee and ankle joints are calculated for both systems. The Bland-Altman graphs showed promising agreement both for in vitro and in vivo experiments. The maximum Root Mean Square Errors (RMSE) between the systems in vitro was 3.4° for hip and 5.9° for knee flexion motion in vivo, respectively. The gait data of the volunteers were assessed between the heel strike and toe off events to investigate the limits of agreement, calculating the population averages and standard deviation for both systems over the gait cycle. The maximum difference was for the ankle joint <6°. The results show that proposed system could be an option as an affordable-democratic solution.
Playing the Petrocene: Toxicity and Intoxication in Leigh Fondakowski’s Spill and Ella Hickson’s Oil
Authors: Hess Linda M. 
Published: May 2022

Abstract
Ella Hickson’s Oil (2016) and Leigh Fondakowski’s Spill (2014) make palpable to their audiences what I call the Petrocene: the age in which human existence has become impossible to conceive without oil. Each play illuminates the pervasive presence of petroleum infrastructures in its own way: while Spill focuses on the specific and sensational crisis of the BP oil spill in the Gulf of Mexico in 2010, Oil presents a series of scenes which focus on two women (mother and daughter) who struggle to carve out their existence in various time periods and in the context of different fossil-energy regimes. Both plays succeed in unveiling not only the toxicity of extractive regimes necessary to fuel the Petrocene, but also the toxicity of the narratives that uphold extractive regimes and their attendant injustices. Moreover, both plays convey the intoxicating effects of oil, which appears as a near-magical substance that promises unfettered progress and access to the good life. Examining these plays in conjunction not only highlights the increasing presence of ecological concerns in dramatic pieces, but also illustrates the ways in which dramatic performance can distill enormous oil infrastructures into apprehensible worlds and thus create vital spaces for pondering the Petrocene.