bluuebunny/crossref_metadata_2025_split huggingface dataset:
Internet usage among women‐led micro and small enterprises and household membersʼ use of the internet at home: Evidence from Indonesia during the COVID‐19 pandemic
Authors: Kusumawardhani Niken , Falentina Anna , Bachtiar Palmira , Indrio Veto 
Published: November 2022

AbstractThis study examines whether internet usage among micro and small enterprises (MSEs) could influence household membersʼ use of the internet in terms of intensity as well as usage for productive activities. Using longitudinal data from MSEs in Yogyakarta, Indonesia, covering the period before and during the COVID‐19 pandemic, the study finds that more intensive use of the internet by female entrepreneurs is positively associated with at least an 8 percentage‐point higher probability of internet use for school‐related purposes by household members. Findings from qualitative analysis indicate that female entrepreneurs who are intensive users of the internet are more effective in persuading their household members to accept use of the internet especially for purposes related to their domain of responsibilities, such as childrenʼs education. We argue that policymakers should focus on improving digital literacy among female entrepreneurs as an affirmative action policy to ensure they can enjoy the maximum benefits that digitalisation has to offer.
Case study of a special event of low‐level windshear and turbulence at the Hong Kong International Airport
Authors: Chan P. W. 
Published: November 2022

AbstractA case study of a special event of low‐level windshear and turbulence at the Hong Kong International Airport is performed. The mountainous Lantau Island to the south of the Airport may lead to terrain‐disrupted airflow disturbances in the Airport area in certain wind directions, resulting in low‐level windshear and turbulence to the aircraft. There are a number of novel features in the flow field in the airport region. First, over the seas to the west of the airport, there is sharp convergence between northerly flow and southerly flow within a short distance. Second, in the temperature measurements over this region, there are sharp increases and decreases in temperature. The performance of a high‐resolution numerical weather prediction model in predicting these features is studied. It is shown that, though the model is quite successful in reproducing some features, it may not be able to capture some novel features, such as a sharp rise of temperature and sharp convergence of the airflow. The case study may be a useful reference for aviation weather forecasters and mountain meteorologists.
Influence of Klebsiella pneumoniae and quinolone treatment on prognosis in patients with pancreatic cancer
Authors: Weniger M , Hank T , Qadan M , Ciprani D , Michelakos T , Niess H , Heiliger C , Ilmer M , D'Haese J G , Ferrone C R , Warshaw A L , Lillemoe K D , Werner J , Liss A , Fernández-del Castillo C 
Published: November 2022

Abstract

Background
An increasing body of evidence suggests that microbiota may promote progression of pancreatic ductal adenocarcinoma (PDAC). It was hypothesized that gammaproteobacteria (such as Klebsiella pneumoniae) influence survival in PDAC, and that quinolone treatment may attenuate this effect.

Methods
This was a retrospective study of patients from the Massachusetts General Hospital (USA) and Ludwig-Maximilians-University (Germany) who underwent preoperative treatment and pancreatoduodenectomy for locally advanced or borderline resectable PDAC between January 2007 and December 2017, and for whom a bile culture was available. Associations between tumour characteristics, survival data, antibiotic use and results of intraoperative bile cultures were investigated. Survival was analysed using Kaplan–Meier curves and Cox regression analysis.

Results
Analysis of a total of 211 patients revealed that an increasing number of pathogen species found in intraoperative bile cultures was associated with a decrease in progression-free survival (PFS) (–1·9 (95 per cent c.i. –3·3 to –0·5) months per species; P = 0·009). Adjuvant treatment with gemcitabine improved PFS in patients who were negative for K. pneumoniae (26·2 versus 15·3 months; P = 0·039), but not in those who tested positive (19·5 versus 13·2 months; P = 0·137). Quinolone treatment was associated with improved median overall survival (OS) independent of K. pneumoniae status (48·8 versus 26·2 months; P = 0·006) and among those who tested positive for K. pneumoniae (median not reached versus 18·8 months; P = 0·028). Patients with quinolone-resistant K. pneumoniae had shorter PFS than those with quinolone-sensitive K. pneumoniae (9·1 versus 18·8 months; P = 0·001).

Conclusion
K. pneumoniae may promote chemoresistance to adjuvant gemcitabine, and quinolone treatment is associated with improved survival.
Extraction and pre‐concentration of parabens in liquid pharmaceutical samples by dispersive liquid–liquid microextraction based on deep eutectic solvents
Authors: Razavi Nourolhoda , Foroutan Fahimeh , Sahebian Samaneh , Vahdati Khaki Jalil 
Published: November 2022

AbstractIn this paper dispersive liquid–liquid microextraction using deep eutectic solvent (DES), as an extraction solvent, was applied for the pre‐concentration and determination of parabens in liquid pharmaceutical samples. A DES composed of a hydrogen bond acceptor [choline chloride (ChCl)] and a hydrogen bond donor (glucose) achieved the highest extraction efficiency. Therefore, this solvent was selected as the extraction solvent. After the synthesis of this solvent, its various properties were investigated. Thermogravimetric analysis, X‐ray diffraction, and Fourier transform infrared spectroscopy were used for this purpose and the successful synthesis of the solvent was confirmed. HPLC with photodiode array detection was used for the analysis of paraben species. Parameters affecting the extraction efficiency were monitored and optimized through univariate analysis and experimental design. Under the optimal conditions (pH of aqueous solution 4.5, ethanol as the disperser solvent, and glucose DES as the extraction solvent), the linearity range of 0.1–5000 ng mL−1was obtained with the coefficient of determination (R2) between 0.993 and 0.9962. Limits of detections ranged from 0.04 to 0.15 ng mL−1, with relative standard deviations from 1.8% to 6.8%. The developed method was applied to the determination of parabens in liquid pharmaceuticals such as ampule, syrups, and nose drop samples. A certain amount of paraben was added to the tested real samples to increase their shelf life. The relative recoveries in these real samples ranged between 80.9% and 103.1%.
Innovative financing and marketing strategies for open spaces – A case of Pune City in India
Authors: Patil Gargi , Vhavale Aniket 
Published: November 2022

AbstractUrbanization in India has been on a rise, as can also be seen in emerging economies like Brazil, China, and Indonesia. India in 2011 was 31.2% urban with 377 million living in urban areas, which increased to 34% in 2017. The urban population is set to increase to 590 million by 2030 placing pressure on Indian infrastructure, which will necessitate the construction of 700 to 900 million square meters of commercial, residential, gardens, parks, and open spaces, in order to meet the demands of urban population. In the present study, gardens and parks in the city of Pune (Maharashtra State, India) and their revenue and expenditure heads (for year 2018–19) have been administered. The paper aims to study how public sector owned gardens and parks can be better utilized for advertising, co‐working spaces, physical fitness centers and be converted into revenue generating assets for the city, which are currently acting as liabilities. Explorative research methodology has been utilized and the study is based on secondary data collected majorly from the local Municipal Corporation office. Important findings of the paper suggest – as to how under‐utilized public gardens and parks can be converted into multifaced, revenue generating areas without hindering the core objective of open places and thereby helping the city level corporation in smoothly fulfilling its roles and responsibilities. The paper would thus play a positive role in aiding the local government to look at innovative sources of financing and thus, reduce its financial dependability on higher levels of government.
Combined use of microbubbles of various sizes and single‐transducer dual‐frequency ultrasound for safe and efficient inner ear drug delivery
Authors: Liao Ai‐Ho , Wang Chih‐Hung , Wang Bo‐Han , Lin Yi‐Chun , Chuang Ho‐Chiao , Liu Hao‐Li , Shih Cheng‐Ping 
Published: November 2022

AbstractWe have previously applied ultrasound (US) with microbubbles (MBs) to enhance inner ear drug delivery, with most experiments conducted using single‐frequency, high‐power density US, and multiple treatments. In the present study, the treatment efficacy was enhanced and safety concerns were addressed using a combination of low‐power‐density, single‐transducer, dual‐frequency US (ISPTA = 213 mW/cm2) and MBs of different sizes coated with insulin‐like growth factor 1 (IGF‐1). This study is the first to investigate the drug‐coating capacity of human serum albumin (HSA) MBs of different particle sizes and their drug delivery efficiency. The concentration of HSA was adjusted to produce different MB sizes. The drug‐coating efficiency was significantly higher for large‐sized MBs than for smaller MBs. In vitro Franz diffusion experiments showed that the combination of dual‐frequency US and large MB size delivered the most IGF‐1 (24.3 ± 0.47 ng/cm2) to the receptor side at the second hour of treatment. In an in vivo guinea pig experiment, the efficiency of IGF‐1 delivery into the inner ear was 15.9 times greater in animals treated with the combination of dual‐frequency US and large MBs (D‐USMB) than in control animals treated with round window soaking (RWS). The IGF‐1 delivery efficiency was 10.15 times greater with the combination of single‐frequency US and large size MBs (S‐USMB) than with RWS. Confocal microscopy of the cochlea showed a stronger distribution of IGF‐1 in the basal turn in the D‐USMB and S‐USMB groups than in the RWS group. In the second and third turns, the D‐USMB group showed the greatest IGF‐1 distribution. Hearing assessments revealed no significant differences among the D‐USMB, S‐USMB, and RWS groups. In conclusion, the combination of single‐transducer dual‐frequency US and suitably sized MBs can significantly reduce US power density while enhancing the delivery of large molecular weight drugs, such as IGF‐1, to the inner ear.
Euglycemic diabetic ketoacidosis in a patient with type 2 diabetes mellitus 3 days after initiating sodium‐glucose cotransporter 2 inhibitor while on an extremely low carbohydrate diet: A case report
Authors: Inoue Ayumi , Katayama Akihiro , Sue Mihiro , Hasegawa Momoka , Maeda Megumi , Matoba Masaki , Ishii Takahiro , Kuribayashi Remi , Tenta Masafumi , Matsushita Yuichi , Takeda Masaya , Iseda Izumi , Wakatsuki Toshiyuki , Hida Kazuyuki 
Published: November 2022

AbstractThis paper presents a case with type 2 diabetes mellitus on a very‐low‐carbohydrate diet who developed euglycemic diabetic ketoacidosis (EDKA) 3 days after starting sodium‐glucose cotransporter 2 inhibitors (SGLT2i). When initiating SGLT2i, healthcare providers should confirm the implementation of a low‐carbohydrate diet and provide intensive guidance to prevent EDKA.
Monster left circumflex artery fistula closure by vascular plug in a patient with post‐COVID‐19 myocardial infarction
Authors: Izadpanah Peyman , Hooshanginezhad Zahra , Shojaie Mohammad 
Published: November 2022

AbstractHerein, we report a man with a huge coronary fistula connecting the left circumflex coronary artery to the right ventricle. During the follow‐up, the patient developed progressive symptoms of heart failure nonresponsive to medical treatment. Therefore, an endovascular closure with a vascular plug was successfully done for him. Transcatheter vascular plug occlusion can be considered as an alternative for closure of symptomatic high‐flow large coronary artery fistulas in patients with a high risk of surgery and chance of coil dislocation, embolization, or unavailability of proper coils.
Quadriplegia from cervical osteomyelodiscitis with vertebral collapse: A case report
Authors: Herrera Danay , Acosta‐Rullan Jose M. , Fox Davide , Concepcion Livasky , Hughes Jessica 
Published: November 2022

AbstractVertebral osteomyelitis is a rare clinical condition accounting for 1%–7% of all bone‐related infections. The increase in chronic diseases such as diabetes mellitus or those that lead to immunosuppression, the increase in spinal instrumentation including epidural catheters for pain management, and the continual increase in intravenous (IV) drug use are factors that have led to the rise in cases. The condition may present subtly without clinical signs and symptoms making early diagnosis difficult. Here, we present a rare case of spontaneous osteodiscitis of the cervical spine complicated by epidural abscess/phlegmon, burst fracture, and spinal cord injury due to methicillin‐resistant Staphylococcus aureus (MRSA) bacteremia in a patient with a history of intravenous drug use who presented with neck pain. The patient was treated with IV antibiotics and decompressive surgery and, however, was unable to regain the mobility of the lower extremities and regained only slight mobility in the upper extremities leading to an ultimate diagnosis of functional quadriplegia.
Bone metastases from renal cell carcinoma: 4 years after aggressive surgeries and anti‐angiogenic therapy
Authors: Nefiss Mouadh , Abid Hichem , Gharbi Mohamed Amine , Bouzidi Ramzi , Teborbi Anis 
Published: November 2022

AbstractManagement of bone metastases from renal cell carcinoma (RCC) has significantly changed after the era of targeted therapy that improved the overall survival (OS). Surgical decision‐making remains a subject of controversy. We report a case of pelvic bone metastasis from RCC, 2 months after nephrectomy and surgery of a revealing clavicular metastasis.
POEMS syndrome: A rare cause of ascites and pelvic effusion
Authors: Ma Jing , Chen Yi , Qin Xiaojin , Liu Xiaogang , Li Ercui , Fan Huijuan , Xie Yandong , Wang Xin 
Published: November 2022

AbstractPOEMS syndrome is a rare clonal plasma cell disease associated with multisystem involvement. We reported a case of 48‐year‐old woman with large volume of exudative ascites with an increased level of λ‐light chain and hepatosplenomegaly. The patient was treated with thalidomide and dexamethasone and showed a good clinical response.
A Simple Substitution on Thyroid Hormones Remarkably Alters the Regioselectivity of Deiodination by a Deiodinase Mimic
Authors: Giri Debasish , Raja Karuppusamy , Mugesh Govindasamy 
Published: November 2022

AbstractThe regioselective deiodinations of L‐thyroxine (T4) play key roles in the thyroid hormone homeostasis. These reactions are catalyzed by three isoforms of the selenoenzymes, iodothyronine deiodinases (Dio1, Dio2 and Dio3), which are highly homologous in nature. Dio1 mediates 5′‐ or 5‐deiodinations of T4 to produce T3 and rT3, respectively. In contrast, Dio2 and Dio3 are selective to 5′‐ or 5‐deiodination to produce T3 and rT3, respectively. Understanding of the regioselectivity of deiodination at the molecular level is important as abnormal levels of thyroid hormone have been implicated in various clinical conditions, such as hypoxia, myocardial infarction, neuronal ischemia and cancer. In this paper, we report that the electronic properties of the iodine atoms in thyroxine (T4) can be modulated through a simple substitution in the 4′‐phenolic moiety. This leads to the change in the regioselectivity of deiodination by different small molecule mimics of Dio enzymes. By using this chemical approach, we also show that the substitution of a strong electron withdrawing group facilitates the removal of all four iodine atoms in the T4 derivative. Theoretical investigations on the hydrogen bonded adducts of T4 with imidazole indicate that the charge on the iodine atoms depend on the nature of hydrogen bond between the −OH group of T4 and the imidazole moiety. While the imidazole can act as either hydrogen bond acceptor (HBA) or hydrogen bond donor (HBD), the protonated imidazole acts exclusively as HBD in T4‐imidazole complex. These studies support the earlier observations that the histidine residue at the active sites of the deiodinases play an important role not only in the substrate binding, but also in altering the regioselectivity of the deiodination reactions.
Intra‐ and Intermolecular Cooperativity in the Catalytic Activity of Phosphodiester Cleavage by Self‐Assembled Systems Based on Guanidinylated Calix[4]arenes
Authors: Lisi Daniele , Vezzoni Carlo Alberto , Casnati Alessandro , Sansone Francesco , Salvio Riccardo 
Published: November 2022

AbstractThe calix[4]arene scaffold, blocked in the cone conformation through alkylation with long alkyl chains, and decorated at the upper rim with four guanidine or arginine units, effectively catalyzes the cleavage of the phosphodiester bond of DNA and RNA model compounds in water. An exhaustive kinetic investigation unequivocally points to the existence of spontaneous aggregation phenomena, driven by hydrophobic effect, occurring at different critical concentrations that depend on the identity of the compound. A pronounced superiority of the assembled structures compared with the monomers in solution was observed. Moreover, the catalytically active units, clustered on the macrocyclic tetrafunctional scaffold, were proved to efficiently cooperate in the catalytic mechanism and result in improved reaction rates compared to those of the monofunctional model compounds. The kinetic analysis is also integrated and corroborated with further experiments based on fluorescence spectroscopy and light scattering. The advantage of the supramolecular assemblies based on tetrafunctional calixarenes leads to believe that the active units can cooperate not only intramolecularly but also intermolecularly. The molecules in the aggregates can probably mold, flex and rearrange but, at the same time, keep an ordered structure that favors phosphodiester bond cleavage. This dynamic preorganization can allow the catalytic units to reach a better fitting with the substrates and perform a superior catalytic activity.
A convolutional neural network (CNN)‐based direct method to detect stiction in control valves
Authors: Akavalappil Vijoy , Radhakrishnan Thota K. , Dave Sanjay K. 
Published: November 2022

AbstractControl valves are considered important capital assets in any process industry. A properly maintained control valve can have a significant impact on how well the process is controlled as well as the overall cost of the plant. However, control valves can suffer from poor control performance due to valve non‐linearities. One of the main reasons for non‐linearity is control valve stiction. Stiction not only causes oscillations in the process variables but also shortens the life of the control valve, resulting in an economic loss for the process. In a process plant, a control engineer generally analyzes the time series plot of process value (PV), set point (SP), and controller output (OP) data and identifies stiction based on the typical shape pattern of PV/SP/OP plot. In this study, the same shape pattern methodology is adapted to identify stiction using convolutional neural network (CNN) technique. A one‐dimensional convolution neural network (Conv1D) algorithm is developed, which works directly on PV/SP/OP time series data for stiction detection. The proposed CNN algorithm is tested on both simulated and industrial control loop data. The suggested method provides promising results with a combined stiction prediction accuracy of 92% (92.2% in predicting non‐sticky and 91.53% in predicting sticky loops) for the industrial loops data studied.
New progress in the extraction and identification of Mexican cochineal (Dactylopius coccus) in fresh dyed wool and dyed wool with artificially accelerated aging and color description
Authors: Cruz Mojica Karen , León Santiago Mayra , Varela García Emiliano , Reyes Lezama Marisol , Tapia Mendoza Everardo 
Published: November 2022

AbstractThe main purpose of this study was to determine if a method developed in the laboratory by HPLC‐ESI‐QToF was able to identify the characteristic compounds of the Mexican cochineal (Dactylopius coccus) in freshly dyed wool fiber and following an artificially accelerated aging process. Wool fibers were dyed with various formulations of popular interest (red‐orange, Mexican red, cochineal red, and purple). These formulations are currently used by indigenous communities in the south of Mexico. Some dyed wools were aged in an UV chamber, in order to simulate the deterioration that a fiber dyed in a previous time could have. Notable results were the identification of the main component, carminic acid, and the respective biomarkers of the Mexican cochineal (dcII, dcIV, and dcVII) with a small amount of sample and in a short time, in three of the four formulations before and after aging, thus providing a method that can probably be used for conservation purposes of cultural heritage. It was concluded that when alum is used as a mordant and as a carbonate pH fixer, the fixation of cochineal on the wool is not very strong. This is one of the few works where Mexican cochineal has been studied, simulating the deterioration due to the passage of time in wool samples of different colors with the same natural dye. As a way of describing the color more objectively, the color was measured with the CIE L*A*B* scale in the four formulations of interest, in recently dyed and artificially aged wool.
Determination of quality grade of tobacco leaf by image processing on correlated color temperature
Authors: Odabas Mehmet Serhat , Şenyer Nurettin , Kurt Dursun 
Published: November 2022

SummaryThe most important factor in tobacco is quality. It is the sum of physical, chemical, and smoking properties that characterize quality. Post‐harvest curing of leaves plays an important role in quality. In this study, an approach based on correlated color temperature (CCT) is proposed to determine the ideal curing time of tobacco leaves. While photographing leaf samples from different days during the curing of tobacco leaves, color correction was made using X‐rite color checker to eliminate the negative effect of ambient light. CCT values were calculated from the repaired photographs using the McCammy method. The inclusion rate of pixels during the calculation is 97%. The equation of CCT variation depending on the day is fitted as . RMSE (26.77 K) and high value were calculated as 98.8% in the equation. CCT values have been converted to quality grade (QG) values to be more understandable. As a result of the study, CCT values ranged between 5000 and 2500 K and corresponding QG values ranged between 79% and 105%. The ideal curing time was calculated as the 17th day after harvesting, the QG value for that day was 100% and the average CCT value was 3000 K.