bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONJUNCTIVAL LIMBAL STEM CELL GRAFTING FOR PRIMARY AS WELL AS RECURRENT PTERYGIUM
Authors: Jalwa Anchal , Jha Alka 
Published: October 2022

Purpose:-
To study the efficacy of conjunctival limbal stem cell grafting in patients with primary as well as recurrent pterygium; to evaluate the change in post-operative best corrected visual acuity; post-operative cosmetic appearance.

Methods:-
The study is prospective, interventional study carried out for a period of two years.70 eyes of 70 patients with primary(progressive) and recurrent pterygium were operated and limbal stem cell grafting was done. The patients were followed-up for a period of 12 months.

Result:-
During the follow-up period pterygium recurred in 4 patients (5.71%). Best corrected visual acuity of 37(52.85%) patients remained stable and in 33(47.14%)patients improved. The post-operative cosmesis was good in 61(87%) cases.

Conclusion:-
Conjunctival Limbal stem cell grafting is a safe and effective procedure in the management of pterygium, with low recurrence rate.
Audit of Blood Bank Services with Emphasis on Loss of Workforce
Authors: Rathi Monika , Chauhan Neetu 
Published: October 2022

Purpose:
The goal of blood bank audit is to continuously improve services to the patients by reducing rework, wastage, and inappropriate care. This can be done by establishing certain quality indicators. The rate of discarded blood and its components due to wastage, expiry, and transfusion-transmitted infection are one of such indicator.

Design:
Retrospective data on the number of whole blood, components prepared, and discarded were collected from the blood bank information system and analyzed.

Results:
During the study period, the total number of blood and components prepared were 3922. Out of which, a total of 226 units (5.76%) were discarded. In order to alleviate the shortage of blood, we should do intermittent auditing, quality monitoring, thorough evaluation and training of staff, proper management of the resources, and workforce.
Intravenous Thrombolysis in Acute Ischemic Stroke
Authors: Khan Javed , Wani Irfan Yousuf , Mufti Showkat , Asimi Ravouf 
Published: October 2022

Background:
Till date, no data has been published about the use of intravenous (IV) thrombolysis in acute ischemic stroke (AIS) from Kashmir valley.

Objective:
The objective of the study is to assess and determine the pattern of use of IV thrombolysis for AIS in Kashmir, including its efficacy and the difficulties faced in providing this modality of treatment.

Materials and Methods:
This was a prospective cross-sectional observational study conducted from July 2016 to July 2018. All those patients who were admitted with a diagnosis of stroke and gave informed consent were included in this study.

Results:
A total of 2023 patients of stroke presented to our emergency department during the study period. Out of them, 1085 (53.6%) cases were found to have hemorrhagic stroke and 938 (46.3%) patients were having ischemic stroke. 9.2% patients of ischemic stroke presented within the window period of thrombolysis, but only 34 (3.6%) patients received IV alteplase. The mean onset to door time in those who received thrombolysis was 103.5 ± 51.17 min. Door-to-needle time (DNT) of ≤60 min was achieved in only 14 (41.2%) cases, whereas mean DNT was 82.7 ± 49.17. There was a statistically significant improvement in the National Institutes of Health Stroke Scale in those who received thrombolysis as compared to those who did not receive it.

Conclusion:
Hemorrhagic stroke occurs in majority of stroke patients (53.6%) in our community. 3.6% of ischemic stroke patients were thrombolyzed. Thrombolytic therapy presented positive outcomes in comparison to nonthrombolyzed patients which, however, was not statistically significant.
Individualized Antigen Expression in Precursor T-Cell Acute Lymphoblastic Leukemia
Authors: El-Gamal Rasha Rasha Abd-El-Rahman , Ismail Mona Ahmed , Mohamed Inas Abdelmoaty , Alfeky Mervat Abdalhameed 
Published: October 2022

BACKGROUND:
In T-acute lymphoblastic leukemia (T-ALL), multi-parametric flow cytometry can serve to detect minimal residual disease (MRD) by using immature or aberrant antigens expression as well as the altered expression of T-cell antigens. The latter approach has been specifically introduced to overcome the absence of leukemia-associated antigens. However, there is no agreed-upon method for the use of T-cell antigens in T-ALL MRD testing.

AIMS AND OBJECTIVES:
To compare the expression of classic T-cell antigens on T-lymphoblasts and T-lymphocytes to establish a protocol for their use in MRD analysis.

MATERIALS AND METHODS:
Flow cytometric data of PB or BM samples from 63 adults with T-ALL were collected. We assessed the frequency and degree of brightness or dimness of each T-cell marker, in addition to studying the uniformity of the events scatter of a total of 287 follow-up BM samples from 50 patients.

RESULTS:
Significant differences in expression intensity of T-cell markers were found between T-lymphoblasts and T-lymphocytes; they were reasonably stable on blasts in follow up samples. This detailed study has nominated the conjoint use sCD3neg/dim and CD5dim/neg in the identification of residual cells, to be supported by other T-cell markers.

CONCLUSION:
The suggested gating sequence showed an acceptable level of accuracy in detecting residual leukemia, supporting their use in T-ALL MRD especially when other distinguishing markers might be absent in the diagnosis sample, or susceptible to be lost with induction therapy.
Drug Therapy in Patients with Severe Forms of Sickle Cell Anemia
Authors: Khaled Safaa A. A. , Ashry Israa E. M. 
Published: October 2022

BACKGROUND AND AIM:
Combining Hydroxycarbamide (hydroxyurea) therapy and L-Carnitine (HU+LC) was proved effective and tolerable in patients with thalassemia intermedia; however, its role in sickle cell anemia (SCA) was not investigated. This study aimed to assess various aspects of treatment with HU + LC in adult patients with severe forms of SCA.

PATIENTS AND METHODS:
Ninety-one adult SCA patients were recruited, then distributed into four treatment groups: Group 1 – 37 patients treated with HU + LC; Group 2 – 16 patients treated with HU; Group 3 – 18 patients treated with LC; and Group 4 – 20 patients received supportive treatment only. Their baseline data were recorded then reassessed 8–12 weeks later. Their compliance was assessed subjectively.

RESULTS:
Patients were nearly matched as regards gender, age, baseline hematologic, and biochemical data. Compared to baseline, HU + LC treatment significantly increased hemoglobin and reduced reticulocytes, white blood cells, mean corpuscular hemoglobin concentration, and lactate dehydrogenase (LDH). Compared with other lines, HU + LC significantly reduced number of painful episodes, blood transfusions, and in hospital days per year. Adding LC to HU improved patient compliance, with mild side effects. Residence, side effects, baseline hemoglobin (Hb), and Hb F% affected patients' compliance. Both gender and age did not show any influence on response to treatment while side effects, compliance, baseline Hb, and LDH displayed a significant effect.

CONCLUSION:
Combining LC with HU for the treatment of adult SCA patients showed superior hematologic and clinical effectiveness. The response was more obvious in severe cases. However, health education about the combination is needed to improve patients' compliance and therapeutic responses.

Trial registration:
Clinical Trials.gov, NCT05081349. https://clinicaltrials.gov/ct2/show/NCT05081349.
A Comparison between Eight Formulas for the Estimation of Plasma Low-Density Lipoprotein Cholesterol in the Saudi Arabian Population
Authors: Awan Zuhier Ahmed , Nuwaylati Dena Abdulbadea 
Published: October 2022

CONTEXT:
Low-density lipoprotein cholesterol (LDL-C) is the classical target in cardiovascular (CV) disease management and is usually estimated by Friedewald's formula. However, this formula may over- or underestimate LDL-C levels.

AIMS:
Our aim is to compare eight LDL-C-estimating formulas to the direct LDL-C measurement and validate their use in the Saudi population.

SETTINGS AND DESIGN:
This was a retrospective study.

SUBJECTS AND METHODS:
A blood sample of fasting 669 Saudi subjects was tested for lipid profiles in King Abdulaziz University Hospital Laboratory, from which directly measured LDL-C was obtained. LDL-C was then estimated from eight different formulas: Friedewald's, Cordova's, Hata's, Puavilai's, Chen's, Ahmadi's, Hattori's, and Vujovic's, which were all compared to direct LDL-C.

STATISTICAL ANALYSIS USED:
Mean and standard deviation, paired t-test, and Pearson's correlation were used for statistical analysis.

RESULTS:
The mean differences between the direct LDL-C and Hattori and Chen's LDL-C were 0.03 and 0.08 mmol/L, respectively; P < 0.001, while the mean difference observed with Hata, Friedewald, Puavilai, and Vujovic's formulas were higher in comparison: 0.15, 0.24, 0.29, and 0.33 mmol/L, respectively, P < 0.001. Ahmadi and Cordova's LDL-C were estimated to be 0.60 and 0.64 mmol/L more than direct LDL-C levels, respectively, which showed the highest discordance with direct LDL-C, P < 0.001. At a triglyceride (TG) level of <4.5 mmol/L, Hattori also had the best agreement with direct LDL-C, with a mean difference of 0.04 mmol/L, and with TG >4.5 mmol/L, their mean difference was 0.21 mmol/L. All estimated LDL-C strongly correlated with direct LDL-C, except for Ahmadi's.

CONCLUSIONS:
Hattori's LDL-C had the best agreement with the direct LDL-C, and across all TG levels. However, we recommend directly measuring LDL-C in those with high CV risk.
Elucidation of mechanisms of action of Wei-Sheng-Fang-Yi-Bao-Dan in the treatment of COVID-19 and depression using network pharmacology and molecular docking
Authors: Han Haicheng , Fang Rui , Wang Dan , Yang Yong , Fu Xiaoqing , Rui Kangle 
Published: October 2022

Purpose: To investigate the mechanisms of action of Wei-Sheng-Fang-Yi-Bao-Dan (WSFYBD) in the treatment of COVID-19 and depression using network pharmacology and molecular docking.
Methods: First, the bioactive components and target genes of WSFYBD were retrieved from TCMSP database. The relevant gene targets of depression and COVID-19 were obtained from databases. The core WSFYBD genes for treatment were separately obtained by determining gene intersection. Cytoscape 3.8.0 software was used to draw the visual interactive networks. STRING database was employed to construct protein-protein interaction networks, while Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses were used to determine the function and pathway of target genes via a Bioconductor/R. Finally, AutoDockTools software was employed for molecular docking.
Results: A total of 105 potential bio-active components and 35 target genes of WSFYBD for COVID-19 therapy were identified. Also, 1905 GO entries (p < 0.05) and 158 related signal pathways (p < 0.05) for COVID-19 were obtained. Similarly, 114 potential bio-active components of WSFYBD and 127 potential therapeutic targets of depression were identified. Moreover, 1948 GO entries (p < 0.05) and 177 related signal pathways for depression were retrieved (p < 0.05). Docking results showed the main bio-active components were closely bound to the core targets.
Conclusion: The mechanisms for treating COVID-19 show that WSFYBD directly acts on SARS-CoV-2 virus to prevent it from entering the host cell, or inhibits virus replication. Secondly, WSFYBD ameliorates depression by acting on key targets that control over-activated cytokines. Therefore, WSFYBD has potentials for the management of COVID-19 and depression.
Bioymifi suppresses Burkitt’s lymphoma cell line proliferation via cell cycle arrest and apoptosis
Authors: Terzi Hatice , Inanır Merve 
Published: October 2022

Purpose: To find a new treatment alternative for Burkitt’s lymphoma, one of the B cell-derived non-Hodgkin's lymphomas that has an extremely aggressive growth profile with a high mortality rate.
Methods: Bioymifi (death receptor agonist) was administered at various doses to Human Burkitt's Lymphoma Raji cell lines, and cell proliferation was evaluated using XTT analysis. Apoptosis induction and cell cycle analysis were assessed using flow cytometry.
Results: Bioymifi exhibited good cytotoxicity in Raji cell lines with IC50 value of 29.5 μM. Furthermore, results of apoptosis induction and cell cycle analysis indicated that Bioymifi had potent anti-proliferative activity through sub-S cell cycle arrest and stimulation of apoptosis (p < 0.05).
Conclusion: Bioymifi has anticancer potentials against Human Burkitt's Lymphoma Raji cell lines. Further pharmacological studies will be required to establish the mechanism of action.
Modelling the Impacts of Immigrants on COVID 19 Transmission Dynamics with Control Measures
Authors: Hugo Alfred K. , Mlay Goodluck M. , Kabigi Moses B. 
Published: October 2022

The COVID-19 pandemic began in Wuhan City in the Hubei province of China in December 2019. The disease spread quickly in many countries around the world due to mobility of people from one location to another. As a result, a COVID-19 mathematical model with the impacts on immigrants was proposed to study its transmission dynamics and possible control measures. The reproduction number was determined by using the next-generation technique and found to be 0.636, indicating that the transmission could be minimized in the community if all immigrants were effectively controlled. The Pontryagin's Maximum Principle was applied in analysing control strategies which are screening of immigrants, provision of public education to raise community awareness, and treatment of infected individuals. The simulated results revealed that a combination of public education, screening of all immigrants, and treatment of infected individuals plays a significant role in reducing COVID-19 transmission in the community.
Keywords: COVID-19; Immigrants; Optimal control theory;
Calidad de Vida: Actividad y Condición Física en mujeres adultas. Un estudio descriptivo (Quality of Life: Physical Activity and Fitness in adult women. A descriptive study)
Authors: Medrano Ureña María del Rocío , Ortega Ruiz Rosario , Benítez Sillero Juan de Dios 
Published: October 2022

Hay gran interés por los beneficios psicológicos que las personas obtienen al realizar actividad física (AF). Practicar AF de forma regular ayuda a mantener una adecuada condición física (CF) y calidad de vida (CV), sin embargo, existe poca literatura científica centrada en la adultez madura. El objetivo de esta investigación ha sido analizar si existen relaciones transversales entre la AF y la CF con los niveles de CV en un grupo de mujeres de mediana edad adscritas a programas de ejercicio físico, de un grupo de 88 mujeres de la provincia de Córdoba con una edad media de 53.85 años. La CF se registró midiendo la altura y el peso y se utilizó la batería de pruebas Senior Fitness Test (SFT); para medir el nivel de AF se utilizó el Cuestionario Internacional de Actividad Física (IPAQ), y para determinar el nivel de CV se usó el Cuestionario de Salud SF-36. Los resultados mostraron que la edad, el IMC, la CF, AF y el comportamiento de AF fueron predictores del componente físico SF-36 explicando el 39% y del componente mental explicando el 46% de su variabilidad. Estos resultados se discuten con relación a las investigaciones previas sobre CV y AF y CF sosteniendo que unos buenos niveles de CF son necesarios para mantener la salud y la CV también en los años del ciclo vital que denominamos madurez de la vida adulta.
Palabras clave. Actividad física, condición física, calidad de vida, mujeres, adultez madura.

Abstract. There is great interest in the psychological benefits that people derive from physical activity (PA). Regular PA helps to maintain adequate physical fitness (PF) and quality of life (QOL), however, there is little scientific literature focused on mature adulthood. The aim of this research was to analyse whether there are cross-sectional relationships between PA and PF with QOL levels in a group of middle-aged women enrolled in physical exercise programmes, from a group of 88 women in the province of Cordoba with a mean age of 53.85 years. PF was recorded by measuring height and weight and the Senior Fitness Test battery (SFT) was used; the International Physical Activity Questionnaire (IPAQ) was used to measure the level of PA, and the SF-36 Health Questionnaire was used to determine the level of QoL. The results showed that age, BMI, PF, PA and PA behaviour were predictors of the SF-36 physical component explaining 39% and of the mental component explaining 46% of its variability. These results are discussed in relation to previous research on QoL and PA and PF arguing that good levels of QF are necessary to maintain health and QoL also in the years of the life cycle that we call mature adulthood.
Key words. Physical activity, physical fitness, quality of life, women, mature adulthood.
Acute response in glycemia and lipemia postprandial after resistance and concurrent training in overweight postmenopausal women
Authors: Rebolledo-Cobos Roberto Carlos , Amador-Rodero Eulalia , Yepes-Charris Yoly , Pulido Tammy , Montealegre Leslie , Becerra Enriquez Jimmy , Sarmiento-Rubiano Luz Adriana 
Published: October 2022

Introduction: In postmenopausal women, metabolic responses to lipids during postprandial periods following combined exercise training are unknown. Objective: To examine the acute effects of resistance training (RT) and concurrent training (CT) on postprandial lipemia and glycemia in postmenopausal women. Methods: This quasi-experimental, exposure response study, linked 27 women who were randomly divided into three groups and evaluated for anthropometry, physical fitness, and nutrition status. Two experimental groups did a session of different types of physical activities (RT or CT), and a control group did not do any training activities (only aerobic exercise). At 12 hours post-training, in fasting conditions, a hypercaloric nutritional compound equivalent to 50% of the basal metabolic rate (BMR) of each woman was supplied. Pre and post hypercaloric intake, biochemical markers (lipemia and glycemia) were determined and compared with the control group. Results: A reduction in total energy expenditure was observed due to RT and CT training (p<0.005). The changes are associated with decreased total cholesterol and low-density lipoprotein levels in the RT group, as well as decreased triglyceride levels and increased high-density lipoprotein levels in the CT and aerobic exercise groups. Conclusion: RT and CT performed 12 hours before the consumption of the hyper caloric nutritional compound can change postprandial lipid and glucose levels. Acute physical training could influence the reduction of energy expenditure and the improvement of glycaemia and lipemia in postmenopausal women.
Keywords: exercise; fitness; glycemia; lipemia; nutrition; postmenopausal; trainings.
Diseño y validación de un instrumento para analizar los estereotipos corporales representados en el software y aplicaciones digitales (Apps) (Design and validation of an instrument for the analysis of images of digital applications (Apps) related to Physical Activity)
Authors: Díaz Barahona José , Valverde Esteve Teresa , Moya Mata Irene 
Published: October 2022

La preocupación por el cuerpo y los estereotipos asociados a la actividad física que transmiten las aplicaciones y el software digital es un fenómeno sustancial pero poco investigado. En el presente estudio, se muestra la validación del proceso de adaptación inicial de un instrumento de medida y de los ítems de la escala, denominado REICAF (Representación de Estereotipos sobre la Imagen Corporal y la Actividad Física), que analiza los estereotipos corporales y de actividad física asociados a las imágenes que aparecen en las Apps y software de carácter deportivo. Se utilizó una metodología descriptiva-transversal siguiendo el protocolo Delphi. La elaboración y validación del instrumento se llevó a cabo gracias a la revisión, tres rondas iterativas realizadas por un panel de seis expertos y al posterior pilotaje del instrumento. La consistencia interna y la confiabilidad de la herramienta reportaron valores muy altos (α=.926), mostrando valores de K≥.626 en todos los ítems. Este estudio concluye que la herramienta puede ser utilizada por docentes e investigadores y creadores de software para adquirir un juicio crítico sobre los estereotipos mencionados.
Palabras clave: alfabetización visual, estereotipos de género, estereotipos corporales, formación docente, instrumentos de evaluación, técnica Delphi.
Abstract. The concern for the body and the stereotypes associated with the physical activity transmitted by digital applications introduced by teachers to energize teaching is a substantial topic, although it has been little researched. This study shows the validation of the initial adaptation process of a measuring instrument and the items of the scale, called ‘REICAF’ (Stereotypes of Body Image and Physical Activity), to analyse the body and physical activity stereotypes associated with the images that appear in Physical Activity Apps and software. We used a descriptive-cross-sectional methodology through Delphi technique, with the participation of a panel of 6 experts (n=6). The elaboration and validation of the instrument was carried out after two rounds of the analysis by the panel of experts and the piloting of the questionnaire. The internal consistency and reliability of the tool reported very high values (α=.926), thus showing values of K≥.626 in all items. This study concludes that the tool can be used for teachers and researchers and software creators to acquire critical judgment about the mentioned stereotypes.
Keywords: evaluation instruments, questionnaire, body stereotypes, gender stereotype, values, teacher training, Delphi technique.
Desacelerar la mirada. En torno a la recuperación afectiva de la memoria
Authors: Arias Osiris , Bogarín Quintana Mario , Liera Cirilo 
Published: October 2022

Este trabajo habla de cómo podríamos utilizar la práctica artística en tanto metodología visual-estética para responder críticamente a la sociedad del espectáculo y a la crisis del hombre unidimensional en la era de las redes sociales. Es por medio de una serie multidisciplinar que hemos encontrado caminos para desacelerar la velocidad con que vemos -sentimos las imágenes, proceso que nos ha llevado a identificarlo como una ruta afectiva-política para recuperar la mirada entendida como aquello que enlaza nuestra subjetividad al mundo.Así mismo, se reflexiona sobre los efectos de las redes sociales en nuestra sensibilidad hacia las fotografía.
Si bien autores como Guy Debord y Herbert Marcuse no aparecen directamente como referencias teóricas en el texto, su presencia y vitalidad están activas en los estudios visuales posicionados desde el legado de una teoría crítica cada vez más necesaria ante la crisis que atraviesa la mirada en una era donde predomina el ocularcentrismo y en él se configuran los diversos regímenes de visualidad a los que, justamente, este trabajo busca responder desde un posicionamiento antivisual y post-fotográfico.
El resultado de la investigación es un cuerpo de obra que parte de la estética antivisual para proponer estrategias para recuperar la mirada y desacelerar el tiempo.