bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of the psychological stress response on nonsuicidal self-injury behavior in students during the COVID-19 epidemic in China: the mediating role of sleep disorders
Authors: Xiao Jiayi , Wang Ruotong , Hu Yan , He Tingxin , Ruan Zhongqiang , Chen Qi , Peng Ziwen 
Published: April 2022

Abstract
Background
The sudden outbreak of COVID-19 had a great impact on the physical and mental health of people all over the world, especially for students whose physical and mental development was not yet mature. In order to understand the physical and mental conditions of students during the epidemic period and provide a theoretical basis for coping with psychological problems in public health emergencies, this study explored the mediating role of sleep disorders in the effect of the psychological stress response (PSR) on non-suicidal self-injury (NSSI), along with the moderating role of emotional management ability (EMA).

Methods
The SRQ-20, Pittsburgh Sleep Quality Index, NSSI Behavior Questionnaire, and Emotional Management Questionnaire were used to investigate the mental health of Chinese students in April 10–20 (Time point 1, T1) and May 20–30 (Time point 2, T2), 2020. A total of 1,955 students (Mage = 19.64 years, 51.4% male) were examined at T1 and 342 students (Mage = 20.06 years, 48.2% male) were reassessed at T2.

Results
Overall, the detection rate of PSR and NSSI were 17.60% (n = 344) and 24.90% (n = 486) respectively in the T1 sample, and were 16.37% (n = 56) and 25.44% (n = 87), in the T2 sample. We also found that sleep disorders played a mediating role in the effect of PSR on NSSI in the T1 and T2 samples. In addition, EMA was shown to regulate the effect of PSR on sleep disorders and the effect of sleep disorders on NSSI in the T1 samples.

Conclusion
We found that PSR resulting from public health emergency might lead to NSSI behaviors in individuals. PSR may also cause sleep disorders, which can bring about NSSI. However, these effects were also moderated by the EMA. This research expands our understanding of PSR and NSSI in students during the pandemic.
Personality traits and anxiety in patients with temporomandibular disorders
Authors: Hekmati Atefeh , Mortazavi Nazanin , Ozouni-Davaji Rahman Berdi , Vakili Mohammadali 
Published: April 2022

AbstractBackgroundTemporomandibular disorders (TMD) have long been suggested to result from psychological factors. Recent studies, however, tend to consider TMD a chronic psychosomatic illness. The present study was designed to explore the association between TMD and personality profile. The Minnesota Multiphasic Personality Inventory-2-Reconstructed form (MMPI-2-RF) was used to evaluate the association for the first time.MethodsA total of 258 subjects participated in this case–control study. TMD cases as detected by the Helkimo index were questioned regarding their personality characteristics and anxiety levels using MMPI-2-RF and Spielberger state and trait anxiety inventory.ResultsPatients with TMD scored higher on all personality characteristics except for Aberrant Experiences. The psychological profile of TMD showed no significant difference between theoretical and experimental Ideas of Persecution means. Patients with TMD reported significantly higher mean levels of state and trait anxiety than controls. The most frequently found anxiety levels in TMD cases have been mild state and trait anxiety (77.5% versus 74.4%).ConclusionPersonality characteristic scores were considerably higher in TMD patients. TMD cases detected by Helkimo index manifest both trait and state anxiety as common findings.
A multi-analytical study of the palette of impressionist and post-impressionist Puerto Rican artists
Authors: Vermeulen Marc , Miranda Annette S. Ortiz , Tamburini Diego , Delgado Sol E. Rivera , Walton Marc 
Published: April 2022

Abstract
This paper presents the pigment characterization in six impressionist and post-impressionist paintings by three leading Puerto Rican artists: Francisco Oller (1833–1917), José Cuchí y Arnau (1857–1925), and Ramón Frade (1875–1954). The paintings, belonging to the Corporación de las Artes Musicales and Museo de Arte de Puerto Rico (San Juan, Puerto Rico), were investigated through a combination of complementary non- and micro-invasive scientific techniques. The use of non-invasive macro-X-ray fluorescence (MA-XRF) and reflectance imaging spectroscopy (RIS) was applied for the first time to characterize Puerto Rican artists’ palette. The non-invasive approach was integrated with spectroscopic techniques such as Raman and/or Fourier-transform infrared (FTIR) spectroscopy, as well as high pressure liquid chromatography coupled to diode array detector and tandem mass spectrometry (HPLC-DAD-MS/MS), when sampling was possible. While this technical investigation reveals pigments that are typical for late 19th/early twentieth century paintings, it also emphasizes some unexpected findings, including the use of cobalt green and synthetic yellow lakes, which enabled the date given to some of the paintings to be refined to post 1910 rather than their current dates of ca. 1890. This study confirms that the Puerto Rican artist’s palettes are very similar to their European contemporaries, underscoring both their European training and their attempt to adapt these methods of painting to a new Caribbean identity emerging from the Spanish American War.
Betahistine alleviates benign paroxysmal positional vertigo (BPPV) through inducing production of multiple CTRP family members and activating the ERK1/2-AKT/PPARy pathway
Authors: Hui Jing , Lei Qi , Ji Zhi , Zi Dingjing 
Published: April 2022

Abstract
Background
Betahistine is a clinical medication for the treatment of benign paroxysmal positional vertigo (BPPV). Otolin, a secreted glycoprotein with a C-terminal globular domain homologous to the immune complement C1q, has been identified as a biomarker for BPPV. However, the role of complement C1q/TNF-related proteins (CTRPs) with a C-terminal globular domain in BPPV is unclear, so we explored the change of CTRPs in betahistine treated BPPV.

Methods
We treated BPPV patients with Betahistine (12 mg/time, 3 times/day) for 4 weeks and observed the clinical efficacy and the expression of CTRP family members in BPPV patients. Then, we constructed a vertigo mice model of vestibular dysfunction with gentamicin (150 mg/Kg) and a BPPV model of Slc26a4loop/loop mutant mice. Adenoviral vectors for CTRP expression vector and small interfering RNA were injected via the intratympanic injection into mice and detected the expression of CTRP family members, phosphorylation levels of ERK and AKT and the expression of PPARγ. In addition, we treated mice of vestibular dysfunction with Betahistine (10 mg/Kg) and/or ERK inhibitor of SCH772984 (12 mg/Kg) and/or and PPARγ antagonist GW9662 (1 mg/Kg) for 15 days, and evaluated the accuracy of air righting reflex, the time of contact righting reflex and the scores of head tilt and swimming behavior.

Results
After treatment with Betahistine, the residual dizziness duration and the score of the evaluation were reduced, and the expression of CTRP1, 3, 6, 9 and 12 were significantly increased in BPPV patients. We also found that Betahistine improved the accuracy of air righting reflex, reduced the time of contact righting reflex and the scores of head tilt and swimming behavior in gentamicin-treated mice and Slc26a4loop/loop mutant mice. The expression levels of CTRP1, 3, 6, 9 and 12, phosphorylation levels of ERK and AKT, and PPARγ expression were significantly increased, and the scores of head tilt and swimming behavior were decreased in vestibular dysfunction mice with overexpression of CTRPs. Silencing CTRPs has the opposite effect. SCH772984 reversed the effect of Betahistine in mice with vestibular dysfunction.

Conclusion
Betahistine alleviates BPPV through inducing production of multiple CTRP family members and activating the ERK1/2-AKT/PPARy pathway.
Development of a 4D hand gripping aid using a knitted shape memory alloy and evaluation of finger-bending angles in elderly women
Authors: Lee Soo-Min , Jung Woo-Kyun , Park Juyeon , Ahn Sung-Hoon 
Published: April 2022

AbstractAs the global population ages, there is an increasing demand for physical assistive devices for the elderly. This study aimed to develop and evaluate a wearable gripping aid for elderly women to assist in their handgrip ability. We developed an actuator module for the hand-gripping aid using a 4D knitted shape memory alloy and attached to a flexible nylon glove. At baseline, we measured the bending angles of the knitted shape memory alloy and the subjects’ fingers while gripping. The bending angles of the gripping aid demonstrated similar hand mobility to those of elderly women in real life. We also found that SMA modules attached to a glove could implement the bending angle when gripping a ball derived from the index and middle fingers of elderly women. The finding could help to develop hand products that could be worn on the hand of the elderly by realizing the bending motion of each finger. The outcomes of this study suggest the practical potential of this wearable device as an effective hand-gripping aid for the elderly, based on a novel 4D material and ergonomic design approach.
A comparison of stress, symptoms, physical activity, and adiposity among women at midlife before and during the pandemic
Authors: Sievert Lynnette Leidy , Shreyer Sofiya , Boudreau Ashley , Witkowski Sarah , Brown Daniel E. 
Published: April 2022

AbstractBackgroundThe COVID-19 pandemic presented challenges that disproportionately impacted women. Household roles typically performed by women (such as resource acquisition and caretaking) became more difficult due to financial strain, fear of infection, and limited childcare options among other concerns. This research draws from an on-going study of hot flashes and brown adipose tissue to examine the health-related effects of the COVID-19 pandemic among 162 women aged 45–55 living in western Massachusetts.MethodsWe compared women who participated in the study pre- and early pandemic with women who participated mid-pandemic and later-pandemic (when vaccines became widely available). We collected self-reported symptom frequencies (e.g., aches/stiffness in joints, irritability), and assessments of stress, depression, and physical activity through questionnaires as well as measures of adiposity (BMI and percent body fat). Additionally, we asked open-ended questions about how the pandemic influenced women’s health and experience of menopause. Comparisons across pre-/early, mid-, and later pandemic categories were carried out using ANOVA and Chi-square analyses as appropriate. The Levene test for homogeneity of variances was examined prior to each ANOVA. Open-ended questions were analyzed for yes/no responses and general themes.ResultsContrary to our hypothesis that women would suffer negative health-related consequences during the COVID-19 pandemic, we found no significant differences in women’s health-related measures or physical activity across the pandemic. However, our analysis of open-ended responses revealed a bi-modal distribution of answers that sheds light on our unexpected findings. While some women reported higher levels of stress and anxiety and lower levels of physical activity, other women reported benefitting from the remote life that the pandemic imposed and described having more time to spend on physical activity or in quality time with their families.ConclusionsIn this cross-sectional comparison of women during the pre-/early, mid-, and later-pandemic, we found no significant differences across means in multiple health-related variables. However, open-ended questions revealed that while some women suffered health-related effects during the pandemic, others experienced conditions that improved their health and well-being. The differential results of this study highlight a need for more nuanced and intersectional research on risk, vulnerabilities, and coping among mid-life women.
Adenocarcinoma in situ detected on a thin-walled lung cavity: a case report
Authors: Sakai Takashi , Azuma Yoko , Koezuka Satoshi , Otsuka Hajime , Sano Atsushi , Tochigi Naobumi , Iyoda Akira 
Published: April 2022

Abstract
Background
Cavitary lesions pathologically diagnosed as adenocarcinoma in situ (AIS) have been rarely reported. The examination of these type of lesions is necessary for a better understanding of the mechanisms underlying their formation and development of more efficient diagnostic and treatment strategies. Here, we present the case of a patient with cavitary lung carcinoma, diagnosed as AIS, who underwent partial resection.

Case presentation
A 72-year-old man presented with an abnormal shadow on chest radiography. Computed tomography findings showed a nodule in the right upper lobe, which was later diagnosed as an adenocarcinoma via transbronchial biopsy. A thin-walled cavity with partial thickening in the right lower lobe was also noted. We suspected that the thin-walled cavitary lesion was malignant, and performed wedge resection during a right upper lobectomy. AIS was diagnosed based on the histopathological findings of the thickened part of the thin-walled cavity.

Conclusions
This study highlights that, although rare, AIS may be observed in cavitary lung carcinoma cases, particularly in thin-walled lesions.
Transcranial Doppler sonography and the effect of haematopoietic stem cell transplantation in sickle cell disease
Authors: Thurn Sylvia , Kleinschmidt Katharina , Kovacic Irena , Wendl Christina , Linker Ralf A. , Corbacioglu Selim , Schlachetzki Felix 
Published: April 2022

Abstract
Background
Sickle cell disease (SCD) is one of the most prevalent monogenetic diseases worldwide and one of the most serious complications is stroke. Transcranial Doppler (TCD) demonstrated to be highly predictive for an imminent stroke by measuring blood flow velocities in the basal cerebral arteries. Currently, the only curative therapy for SCD is hematopoietic stem cell transplantation (HSCT). The aim of this study is to verify the correlation between blood flow velocities and stroke including the effect of HSCT.

Methods
In our retrospective single-center study a total of 26 sickle cell patients (HbSS, HbSß+-thalassemia, HbSSα-thalassemia minima, HbSSα-thalassemia minor and HbSC) were analyzed between 2010 and 2016. The highest time averaged maximum mean blood flow velocity (TAMMV) measured was documented and evaluated with respect to SCD genotype and effect of HSCT. Acute and symptomatic as well as silent strokes were recorded as separate parameters.

Results
In our study, ten patients had normal blood flow velocities before HSCT (six HbSS and four HbSß+-thalassemia patients) and 13 patients presented with abnormal TCD (eight HbSS, three HbSSα-thalassemia minima, one HbSSα-thalassemia minor and one HbSC). Thirteen of 26 study participants (ten HbSS and three HbSß+-thalassemia patients) received HSCT. In two patients, TAMMV in basal cerebral arteries remained “normal”, in one they remained conditional and in one TAMMV was reduced to normal. Four of 26 study participants (15.4%), including all patients with HbSS genotype, presented with a stroke, but none had “abnormal” TAMMV with TCD performed after the onset of stroke in each case. At the time we performed the TCD, the patients had already suffered the stroke.

Conclusion
In our study, none of the patients with stroke displayed abnormal blood flow velocities in TCD. Yet, HSCT at this stage of the disease still had a positive effect on TAMMV. Further studies are needed whether this effect converts into reduced stroke risk at all or only selected SCD patients undergoing HSCT.
Predictors of mortality within the first year post-hepatectomy for hepatocellular carcinoma
Authors: Sheriff Sanaa , Madhavan Sudharsan , Lei Geraldine Yanlei , Chan Yiong Huak , Junnarkar Sameer P. , Huey Cheong Wei , Low Jee Keem , Shelat Vishal G. 
Published: April 2022

Abstract
Background
Hepatic resection (HR) for hepatocellular carcinoma (HCC) is safe with good perioperative and long-term oncologic outcomes. There is a paucity of data with regards to intermediate-term outcomes (i.e., beyond 90-day and within 1-year mortality). This paper studies the risk factors for within 1-year mortality after elective HR with curative intent in patients with HCC.

Methods
An audit of patients who underwent curative HR for HCC from January 2007 to April 2016 was conducted. Univariate and multivariate analysis were sequentially performed on perioperative variables using Cox-regression analysis to identify factors predicting intermediate-term outcomes defined as within 1-year mortality. Kaplan–Meier survival curves and hazard ratios were obtained.

Results
Three hundred forty-eight patients underwent HR during the study period and 163 patients had curative hepatectomy for HCC. Fifteen patients (9.2%) died within 1-year after HR. Multivariate analysis identified Child-Pugh class B/C (HR 5.5, p = 0.035), multinodularity (HR 7.1, p = 0.001), macrovascular invasion (HR 4.2, p = 0.04) postoperative acute renal failure (HR 5.8, p = 0.049) and posthepatic liver failure (HR 9.6, p = 0.009) as significant predictors of 1-year mortality.

Conclusion
One-year mortality following HR for HCC remains high and can be predicted preoperatively by multinodularity, Child-Pugh class, and macrovascular invasion. Postoperative acute renal failure and liver failure are associated with 1-year mortality.
Effect of achieving sustained virological response with direct-acting antiviral agents on glycemic control in diabetic patients with chronic hepatitis C infection
Authors: El-Kassas Mohamed , El-Folly Runia , Aboromia Maram , Aly Heba , Bahgat Mohamed , Hamed Mostafa 
Published: April 2022

Abstract
Background
Hepatitis C virus (HCV) is a significant cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma worldwide. Liver disease is not the only problem caused by chronic HCV infection; many extrahepatic complications, such as insulin resistance, can be associated with HCV infection. The aim of this study was to assess the effect of achieving a sustained virological response after treatment with directly acting antiviral drugs on insulin resistance in patients with chronic HCV infection.

Results
This prospective study was conducted on 46 HCV patients with type 2 diabetes mellitus who received directly acting antiviral drugs for HCV infections. Fasting insulin, fasting blood glucose, and lipid profiles were assessed in all patients at three time points: before treatment, at the end of treatment, and 12 weeks after the end of treatment. Despite using three different directly acting antiviral drug regimens, all patients achieved a sustained viral response, regardless of the regimen used. the Homeostatic Model Assessment for Insulin Resistance decreased significantly at the end of treatment; however, when recalculated at week 12 after end of treatment, the reduction of the Homeostatic Model Assessment for Insulin Resistance was not significant compared to the baseline levels. Total cholesterol and low-density lipoproteins increased at the end of treatment and continued to increase for 12 weeks after the end of treatment.

Conclusions
Improvements in insulin resistance and glycemic control were noted in HCV patients at the end of treatment with directly acting antiviral drugs; this effect was also apparent after 12 weeks. An increase in the levels of total cholesterol and low-density lipoprotein can be expected after treatment with directly acting antiviral drugs.
Feasibility, safety and effectiveness of laparoscopic transperitoneal pyeloplasty in children: Ain Shams University early experience
Authors: Mohamed Hany Emad , EL-Asmar Khaled Mohamed , Hassan Tarek Ahmed , EL-Shafei Ehab Abd El-Aziz , Soliman Mohamed Hisham , Allam Ayman Mostafa 
Published: April 2022

Abstract
Background/purpose
Laparoscopic pyeloplasty (LP) is now widely recognized as a minimally invasive alternative for the surgical repair of ureteropelvic junction obstruction (UPJO) in paediatrics. In this work, we aim to evaluate the feasibility, safety and effectiveness of LP in our early experience.

Patients and methods
Between April 2019 and April 2020, patients presented with indication for surgical repair of UPJO were offered laparoscopic transperitoneal Anderson-Hynes pyeloplasty. Demographic data, preoperative investigations, operative data and intra- or postoperative complications, as well as short and mid-term follow-ups were recorded.

Results
During the specified period, 13 patients underwent LP (8 girls and 5 boys) with a median age of 12 months (range from 5 to 150 months). There was no conversion to open approach with operative time ranging from 120 to 240 min (mean = 175 ± 34 min). No intra- or postoperative complications were encountered. One to 2 years postoperative follow-up was performed (median = 18 months) in 11 patients. One patient discontinued follow-up after 1 month and another after 6 months. Follow-up PAUS showed a reduction in the anteroposterior diameter of the renal pelvis in all cases. Postoperative diuretic renal scans (DTPA renography) were done for three patients with a persistent anteroposterior diameter of the renal pelvis greater than 20 mm which showed improvement in the washout. All patients had a good cosmetic outcome.

Conclusion
In our early experience in LP, we found the procedure a safe, feasible and effective technique in managing UPJO in children and infants with good cosmetic outcome.

Level of evidence
This is a case series study (level IV evidence).
Minimal Residual Disease After Autologous Stem-Cell Transplant for Patients With Myeloma: Prognostic Significance and the Impact of Lenalidomide Maintenance and Molecular Risk
Authors: de Tute Ruth M. , Pawlyn Charlotte , Cairns David A. , Davies Faith E. , Menzies Tom , Rawstron Andy , Jones John R. , Hockaday Anna , Henderson Rowena , Cook Gordon , Drayson Mark T. , Jenner Matthew W. , Kaiser Martin F. , Gregory Walter M. , Morgan Gareth J. , Jackson Graham H. , Owen Roger G. 
Published: April 2022

PURPOSE Minimal residual disease (MRD) can predict outcomes in patients with multiple myeloma, but limited data are available on the prognostic impact of MRD when assessed at serial time points in the context of maintenance therapy after autologous stem-cell transplant (ASCT) and the interaction between MRD and molecular risk. METHODS Data from a large phase III trial (Myeloma XI) were examined to determine the relationship between MRD status, progression-free survival (PFS), and overall survival (OS) in post-ASCT patients randomly assigned to lenalidomide maintenance or no maintenance at 3 months after ASCT. MRD status was assessed by flow cytometry (median sensitivity 0.004%) before maintenance random assignment (ASCT + 3) and 6 months later (ASCT + 9). RESULTS At ASCT + 3, 475 of 750 (63.3%) patients were MRD-negative and 275 (36.7%) were MRD-positive. MRD-negative status was associated with improved PFS (hazard ratio [HR] = 0.47; 95% CI, 0.37 to 0.58 P < .001) and OS (HR = 0.59; 95% CI, 0.40 to 0.85; P = .0046). At ASCT + 9, 214 of 326 (65.6%) were MRD-negative and 112 (34.4%) were MRD-positive. MRD-negative status was associated with improved PFS (HR = 0.20; 95% CI, 0.13 to 0.31; P < .0001) and OS (HR = 0.33; 95% CI, 0.15 to 0.75; P = .0077). The findings were very similar when restricted to patients with complete response/near complete response. Sustained MRD negativity from ASCT + 3 to ASCT + 9 or the conversion to MRD negativity by ASCT + 9 was associated with the longest PFS/OS. Patients randomly assigned to lenalidomide maintenance were more likely to convert from being MRD-positive before maintenance random assignment to MRD-negative 6 months later (lenalidomide 30%, observation 17%). High-risk molecular features had an adverse effect on PFS and OS even for those patients achieving MRD-negative status. On multivariable analysis of MRD status, maintenance therapy and molecular risk maintained prognostic impact at both ASCT + 3 and ASCT + 9. CONCLUSION In patients with multiple myeloma, MRD status at both ASCT + 3 and ASCT + 9 is a powerful predictor of PFS and OS.