bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of conduction disorders after transcatheter aortic valve implantation: results of the EHRA survey
Authors: Badertscher Patrick , Knecht Sven , Zeljković Ivan , Sticherling Christian , de Asmundis Carlo , Conte Giulio , Barra Sérgio , Jedrzej Kosiuk , Kühne Michael , Boveda Serge 
Published: February 2022

AbstractConduction disorders such as left bundle branch block (LBBB) are common after transcatheter aortic valve implantation (TAVI). Consensus regarding a reasonable strategy to manage conduction disturbances after TAVI has been elusive. The European Heart Rhythm Association (EHRA) conducted a survey to capture contemporary clinical practice for conduction disorders after TAVI. A 25-item online questionnaire was developed and distributed among the EHRA electrophysiology (EP) research network centres. Of 117 respondents, 44% were affiliated with university hospitals. A standardized management protocol for advanced conduction disorders such as LBBB or atrioventricular block (AVB) after TAVI was available in 63% of participating centres. Telemetry after TAVI was chosen as the most frequent management strategy for patients with new-onset or pre-existing LBBB (79% and 70%, respectively). Duration of telemetry in patients with new-onset LBBB varied, with a 48-h period being the most frequently chosen, but almost half monitoring continued for at least 72 h. Similarly, in patients undergoing EP study due to new-onset LBBB, the HV interval cut-off point leading to pacemaker implantation was heterogeneous among European centres, although an HV &gt;75 ms threshold was the most common. Conduction system pacing was chosen as a preferred approach by 3.7% of respondents for patients with LBBB and normal left ventricular ejection fraction (LVEF), and by 5.6% for patients with LBBB and reduced LVEF. This survey suggests some heterogenity in the management of conduction disorders after TAVI across European centres. The risk stratification strategies vary substantially. Conduction system pacing in patients with LBBB after TAVI is still underused.
Methylation quantitative trait loci are largely consistent across disease states in Crohn’s disease
Authors: Venkateswaran Suresh , Somineni Hari K , Kilaru Varun , Katrinli Seyma , Prince Jarod , Okou David T , Hyams Jeffrey S , Denson Lee A , Kellermayer Richard , Gibson Greg , Cutler David J , Smith Alicia K , Kugathasan Subra , Conneely Karen N 
Published: February 2022

Abstract
Recently, we identified 1,189 CpG sites whose DNA methylation level in blood associated with Crohn’s disease. Here, we examined associations between DNA methylation and genetic variants to identify methylation quantitative trait loci across disease states in (1) 402 blood samples from 164 newly diagnosed pediatric Crohn’s disease patients taken at 2 time points (diagnosis and follow-up), and 74 non-inflammatory bowel disease controls, (2) 780 blood samples from a non-Crohn’s disease adult population, and (3) 40 ileal biopsies (17 Crohn’s disease cases and 23 non-inflammatory bowel disease controls) from group (1). Genome-wide DNAm profiling and genotyping were performed using the Illumina MethylationEPIC and Illumina Multi-Ethnic arrays. SNP-CpG associations were identified via linear models adjusted for age, sex, disease status, disease subtype, estimated cell proportions, and genotype-based principal components. In total, we observed 535,448 SNP-CpG associations between 287,881 SNPs and 12,843 CpG sites (P &lt; 8.21 × 10−14). Associations were highly consistent across different ages, races, disease states, and tissue types, suggesting that the majority of these methylation quantitative trait loci participate in common gene regulation. However, genes near CpGs associated with inflammatory bowel disease SNPs were enriched for 18 KEGG pathways relevant to inflammatory bowel disease-linked immune function and inflammatory responses. We observed suggestive evidence for a small number of tissue-specific associations and disease-specific associations in ileum, though larger studies will be needed to confirm these results. Our study concludes that the vast majority of blood-derived methylation quantitative trait loci are common across individuals, though a subset may be involved in processes related to Crohn’s disease. Independent cohort studies will be required to validate these findings.
Anglo-Jewish Humanitarianism and the Jewish Relief Unit, 1943–1950
Authors: Sampson Tom 
Published: February 2022

Abstract
The Jewish Relief Unit (JRU) was an Anglo-Jewish humanitarian agency of 213 members that operated across Europe during 1945/50, particularly in the British Zone of Occupation in Germany. JRU staff cared for the hundreds of thousands of Jewish Displaced Persons (DPs) who lingered in United Nations Relief and Rehabilitation Administration (UNRRA) assembly centres such as Belsen before their eventual departure for the United States or the new state of Israel. The JRU has remained a somewhat understudied body relative to other Jewish organizations active in DP camps and this article, based on personnel files and field reports archived at London’s Wiener Library and the London Metropolitan Archives, centres JRU aid workers as valuable objects of study in their own right, in line with increased historiographical interest in the backgrounds and world-views of postwar UNRRA operatives. Through an emphasis on materials related to and produced by individual JRU staff members and on the intimate and everyday character of their work, this article suggests that the JRU work among Jewish DPs in Germany was more substantive and consequential than has often been appreciated. More broadly, the work of the JRU is suggestive of the significance of humanitarian relief and reconstruction to postwar Jewish revival in Germany.
A Scoping Review of Research on Older People and Intergenerational Relations in the Context of Climate Change
Authors: Ayalon Liat , Roy Senjooti , Aloni Omer , Keating Norah 
Published: February 2022

AbstractBackground and ObjectivesIn view of the inherited temporal dimension of climate change, this study aims to highlight diverse intergenerational effects and coping strategies by examining the state of literature on older people and intergenerational relations in the context of climate change.Research Design and MethodsA scoping review of peer-reviewed scientific literature was conducted. We searched the following bibliographical data sets: PubMed, Web of Science, and APA PsycNet in addition to a snowballing search based on Google Scholar. The primary search was conducted between September 22, 2021 and September 26, 2021, using variations of the search terms: older people AND intergenerational AND climate change. Two independent raters classified the articles using prespecified inclusion and exclusion criteria.ResultsIn total, 20 articles were maintained for data extraction. Articles reflect 2 poles in relation to older people and intergenerational relations in the context of climate change. The first emphasizes intergenerational conflicts and differences, whereas the second stresses solidarity and transmission of knowledge and practices between the generations.Discussion and ImplicationsBoth older and younger people are affected by age-based discrimination in the context of climate change. Generational differences in energy consumption and attitudes toward climate change exist. Nonetheless, these can be overcome by stressing the solidarity between the generations and the ability of older people to contribute to the climate change movement as well as by the ability of both young and old to transmit knowledge and practices related to sustainability.
Are the Patterns of Cytomegalovirus Viral Load Seen After Solid Organ Transplantation Affected by Circadian Rhythm?
Authors: Rafferty Hannah , Murray Matthew J , Tam Jerry C H , Macfarlane Alastair , Smith Colette , Lumley Sheila F , Atabani Sowsan , McKeating Jane A , Sharma Dinesh , Reeves Matthew , Whitmore David , Griffiths Paul 
Published: February 2022

Abstract

Background
Cytomegalovirus (CMV) is an important opportunistic pathogen after transplantation. Some virological variation in transplant recipients is explained by donor and recipient CMV serostatus, but not all. Circadian variability of herpesviruses has been described, so we investigated the effect of time of day of transplantation on posttransplant CMV viremia.

Methods
We performed a retrospective analysis of 1517 patients receiving liver or kidney allografts at a single center from 2002 to 2018. All patients were given preemptive therapy with CMV viremia monitoring after transplantation. Circulatory arrest and reperfusion time of donor organ were categorized into 4 periods. Patients were divided into serostatus groups based on previous CMV infection in donor and recipient. CMV viremia parameters were compared between time categories for each group. Factor analysis of mixed data was used to interrogate this complex data set.

Results
Live-donor transplant recipients were less likely to develop viremia than recipients of deceased-donor organs (48% vs 61%; P &lt; .001). After controlling for this, there was no evidence of time of day of transplantation affecting CMV parameters in any serostatus group, by logistic regression or factor analysis of mixed data.

Discussion
We found no evidence for a circadian effect of transplantation on CMV viremia, but these novel results warrant confirmation by other centers.
Embracing multiple aims in healthcare improvement and innovation
Authors: Amalberti Rene , Staines Anthony , Vincent Charles 
Published: February 2022

Abstract

Background
Healthcare and other industries have to manage and coordinate a number of different aims and longer-term ambitions. They must maintain quality, manage costs, support and retain the workforce, manage regulatory demands and consider wider societal objectives. These aims are all legitimate, but they are not necessarily aligned, neither in their time frame nor in their nature. Conflicts between aims have a profound influence on the implementation of safety and quality improvement and wider innovation system change. Healthcare leaders understand that these aims may conflict, but the extent and nature of such conflicts have been underestimated.

Objective
This paper aims to support medical and nursing leadership and executives in the complex task of managing multiple aims in relation to improvement and innovation.

Methods
We drew on our experience and the wider industrial and healthcare literature to find examples of studies and improvement projects with multiple aims and examples of innovation and change in which conflicting aims were apparent. We sought to identify principles that would enable the management of parallel aims and practical strategies that might facilitate implementation.

Results
We argue that almost all improvement and innovation in healthcare should address parallel aims, actively seek to articulate these aims and manage potential conflicts between them. We propose four underlying principles to support a more productive approach to the identification and management of parallel aims: embrace multiple aims, consider both short- and long-term aims and ambitions, consider the wider societal context and appreciate that all changes take place within an evolving, dynamic context. In terms of practical actions, we identified five key strategies: (i) identify and monitor the parallel aims and accept that some will conflict; (ii) slow down to accommodate the natural flexibility of the system; (iii) think both the short term and the long term; (iv) expect and endeavour to anticipate some unintended consequences and (v) resist downgrading the project to partial implementation.

Conclusions
We have argued that most improvement and innovation, unlike controlled trials, should consider multiple aims. We set out some broad principles and practices to reduce conflict and suggest avenues to manage conflicts and support positive synergies. We suggest that if this is not done, conflicts are much more likely to arise, which will be detrimental to the change process. Articulating the multiple aims and actively seeking to manage them in parallel will promote a more flexible and productive approach to innovation and change.
P22 Youth as agents of change in raising AMR awareness in the community in Dodoma region
Authors: Venant Erick , Stanley Baritazar K. , Mosha Michael J. , Mushi DorineGrace J. , Mwingira Israel , Harrison Roger , Wiedenmayer Karin , Ombaka Eva 
Published: February 2022

Abstract

Introduction
One of the strategic objectives of the AMR national action plan is to improve public awareness and understanding of AMR. Changing people's behaviour is not easy and the older a person is, the more they are set in their ways. Schoolchildren are in their formative years, which is the right time to impart knowledge and best practices that will guide their behaviour in life. Importantly, students have links with families and communities and are future leaders. Roll Back Antimicrobial resistance Initiative (RBA Initiative) has been pioneering the use of youth as agents of change to increase AMR awareness, promote positive behavioural change and thus reduce treatment failure.

Objectives
The main objective was to equip young people (schoolchildren) with knowledge and skills to understand antimicrobial use and resistance and ability to pass the knowledge to their families, other students and community at large.

Methods
Through AMR clubs, RBA Initiative used different methodologies to engage and educate schoolchildren on AMR. These included classroom teaching, arts and crafts like songs, skits, drama, traditional dances and storytelling and fun videos. Further motivation for active participation was encouraged through competition. The content of the training included topics such as behaviour that fuels AMR, hand hygiene and sanitation, the impact of fake drugs and the One Health approach.

Results
In 2020, the project build the capacity of 160 students. Subsequently, these trained students have reached over 1000 fellow secondary school students, over 3000 primary school pupils and over 800 community members including family members with key AMR messages.

Conclusions
If engaged and empowered, young people are able to increase community knowledge and awareness regarding AMR as agents of change, contributing to the national action plan on AMR.
Treatment Decisions in Patients With Potentially Nonsurvivable Burn Injury in Australia and New Zealand: A Registry-Based Study
Authors: Tracy Lincoln M , Gold Michelle , Reeder Sandra , Cleland Heather J 
Published: February 2022

Abstract
Whilst burn-related mortality is rare in high-income countries, there are unique features related to prognostication that make examination of decision-making practices important to explore. Compared to other kinds of trauma, burn patients (even those with nonsurvivable injuries) may be relatively stable after injury initially. Complications or patient comorbidity may make it clear later in the clinical trajectory that ongoing treatment is futile. Burn care clinicians are therefore required to make decisions regarding the withholding or withdrawal of treatment in patients with potentially nonsurvivable burn injury. There is yet to be a comprehensive investigation of treatment decision practices following burn injury in Australia and New Zealand. Data for patients admitted to specialist burn services between July 2009 and June 2020 were obtained from the Burns Registry of Australia and New Zealand. Patients were grouped according to treatment decision: palliative management, active treatment withdrawn, and active treatment until death. Predictors of treatment initiation and withholding or withdrawing treatment within 24 hours were assessed using multilevel mixed-effects logistic regression. Descriptive comparisons between treatment groups were made. Of the 32,186 patients meeting study inclusion criteria, 327 (1.0%) died prior to discharge. Fifty-six patients were treated initially with palliative intent and 227 patients had active treatment initiated and later withdrawn. Increasing age and burn size reduced the odds of having active treatment initiated. We demonstrate differences in demographic and injury severity characteristics as well as end of life decision-making timing between different treatment pathways pursued for patients who die in-hospital. Our next step into the decision-making process is to gain a greater understanding of the clinician’s perspective (eg, through surveys and/or interviews).
HDL quality features revealed by proteome‒lipidome connectivity are associated with atherosclerotic disease
Authors: Wang Dandan , Yu Bilian , Li Qingrun , Guo Yanhong , Koike Tomonari , Koike Yui , Wu Qingqing , Zhang Jifeng , Mao Ling , Tang Xiaoyu , Sun Liang , Lin Xu , Wu Jiarui , Chen Y Eugene , Peng Daoquan , Zeng Rong 
Published: February 2022

AbstractLipoprotein, especially high-density lipoprotein (HDL), particles are composed of multiple heterogeneous subgroups containing various proteins and lipids. The molecular distribution among these subgroups is closely related to cardiovascular disease (CVD). Here, we established high-resolution proteomics and lipidomics (HiPL) methods to depict the molecular profiles across lipoprotein (Lipo-HiPL) and HDL (HDL-HiPL) subgroups by optimizing the resolution of anion-exchange chromatography and comprehensive quantification of proteins and lipids on the omics level. Furthermore, based on the Pearson correlation coefficient analysis of molecular profiles across high-resolution subgroups, we achieved the relationship of proteome‒lipidome connectivity (PLC) for lipoprotein and HDL particles. By application of these methods to high-fat, high-cholesterol diet-fed rabbits and acute coronary syndrome (ACS) patients, we uncovered the delicate dynamics of the molecular profile and reconstruction of lipoprotein and HDL particles. Of note, the PLC features revealed by the HDL-HiPL method discriminated ACS from healthy individuals better than direct proteome and lipidome quantification or PLC features revealed by the Lipo-HiPL method, suggesting their potential in ACS diagnosis. Together, we established HiPL methods to trace the dynamics of the molecular profile and PLC of lipoprotein and even HDL during the development of CVD.
The relationship between plant and butterfly richness and composition and socioecological drivers in five adjacent cities along the Mediterranean Coast of Israel
Authors: Keren Itay , Malkinson Dan , Dorman Michael , Balaban Amir , Bar (Kutiel Pua 
Published: February 2022

Abstract
Urbanization is the land-use process that most significantly impacts flora and fauna. We conducted a multiple city comparison of two taxa to assess whether richness patterns are similar across cities and taxa. This study aimed to examine the effects socioecological factors, namely open area size, socioeconomic status and the built-up cover, on species richness and composition of plants and butterflies in five adjacent Mediterranean cities in Israel’s coastal plain. Vegetation surveys were conducted in 170 open area sites in various urban settings. In 34 of them, the presence of butterfly species was also recorded. Mixed-effect generalized linear models were used to examine the site's characteristics effect on the species richness. The identity of each city was included as a random effect in the models. Results indicated that overall plant species richness increased with patch size, whereas butterfly richness was not associated with this factor. Plant and butterfly species richness in all categories decreased with the increase in building cover, except for endemic plant species. The results demonstrate the complex contribution of urban open area patches to the biodiversity of different taxa, being conditional on their size, surrounding built-up area and socioeconomic values.
Protecting foreign investments in revolution and civil war: critiquing the contemporary arbitral practice
Authors: Greenman Kathryn 
Published: February 2022

Abstract
The protection of foreign investment during times of revolution and civil war, and especially against acts of non-state forces, has a history—both recent and longer past. The issue has re-emerged as a result of the series of revolutions and civil wars, known as the Arab Spring. This is demonstrated by several recent awards against Libya, Egypt and Syria, as well as a number of pending claims. This article considers what a critique of this practice might look like and how it might fit in with existing critiques of international investment law. It argues first, that the contemporary arbitral practice concerning investment protection during revolution and civil war encourages a particular type of security state—and a particular type of state violence—along gendered and racialised lines and second, that it domesticates revolution and restrains revolutionary contestation of the prevailing economic order.
Floating sanctuaries: The ethics of search and rescue at sea
Authors: Mann Itamar , Mourão Permoser Julia 
Published: February 2022

AbstractSearch-and-Rescue NGOs in the Mediterranean have been increasingly criminalized. This criminalization has chilled conversation about the ethical dilemmas practitioners face. What, if any, can be the adverse byproducts of rescuing life at sea? In this article, we concentrate on the dilemmas involved in search and rescue (SAR) as rescuers have described them. Our aim is two-fold. The first is to offer a phenomenological account of search-and-rescue dilemmas. The article sheds light on the complexity and nuance of the ethical landscape of maritime rescue, revealing an intricate web of interactions acknowledged by rescuers as posing ethical challenges. The second aim is to offer a conceptual framework for what it is that SAR NGOs are, in fact, doing. We contextualize their actions within the larger terrain of ‘border externalization’, in which states have moved enforcement activities to extraterritorial zones, where human rights law is diluted or inapplicable. We thus argue that the set of norms underlying NGO rescue practices amounts to a strategy of counter-externalization. The ideal here is that a window of opportunity can be created at sea, where human rights or international law protections more broadly apply, but enforcement powers of states are suspended. By utilizing these legal gray zones to the benefit of migrants, rescuers effectively turn extraterritorial zones from spaces of lawlessness into spaces of resistance. The rescue ship thus becomes a ‘floating sanctuary’.
Disc precession to explain the superorbital modulation of LMC X-4: results from the Swift monitoring campaign
Authors: Ambrosi E , D’Aì A , Del Santo M , Segreto A , Ferrigno C , Amato R , Cusumano G 
Published: February 2022

ABSTRACT
We studied the spectral changes of the high-mass X-ray binary system LMC X-4 to understand the origin and mechanisms beyond its superorbital modulation (30.4 d). To this aim, we obtained a monitoring campaign with Swift/XRT (0.3–10 keV) and complemented these data with the years-long Swift/BAT survey data (15–60 keV). We found a self-consistent, physically motivated, description of the broad-band X-ray spectrum using a Swift/XRT and a NuSTAR observation at the epoch of maximum flux. We decomposed the spectrum into the sum of a bulk + thermal Comptonization, a disc reflection component, and a soft contribution from a standard Shakura–Sunyaev accretion disc. We applied this model to 20 phase-selected Swift spectra along the superorbital period. We found a phase-dependent flux ratio of the different components, whereas the absorption column does not vary significantly. The disc emission is decoupled with respect to the hard flux. We interpret this as a geometrical effect in which the inner parts of the disc are tilted with respect to the obscuring outer regions.