bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sydnone: Synthesis, Reactivity and Biological Activities
Authors: Zerbib Souad , Khouili Mostafa , Catto Marco , Bouissane Latifa 
Published: June 2022

Abstract:
Sydnones are among the most well-known mesoionic compounds. Since their
synthesis in 1935 by Earl and Mecknay, numerous researches have shown that the chemical
behavior, physical and biological properties of sydnones make them the most useful
compounds in organic chemistry. Sydnones undergo thermal 1,3-dipolar cycloaddition reaction
with dipolarophiles (alkynes or alkenes) to give exclusively derivatives containing
a pyrazole moiety exhibiting numerous applications, such as pharmaceuticals and agrochemicals.
However, the sydnone cycloaddition reaction with alkynes requires harsh conditions,
like high temperatures and long reaction times, giving poor regioselectivity to the
resulting products. To overcome these constraints, new reactions named CuSAC (Copper-
Catalyzed Sydnone-Alkyne Cycloaddition) and SPSAC (Strain-Promoted Sydnone-
Alkyne Cycloaddition) have been developed, leading to pyrazoles with interesting constant
kinetics.
Rationally-designed Chitosan-based Polymeric Nanomaterials
According to Intrinsic Characteristics for Cancer Therapy and
Theranostics: A Review
Authors: Yu Fangying , Zhu Yun , Shang Xuwei , Yuan Hong , Hu Fuqiang 
Published: June 2022

Abstract:
Chitosan, the only naturally occurring polycationic polysaccharide derived
from chitin, has long case been implicated in the designs of nanosystems for diverse
biomedical and pharmaceutical applications owing to its exclusive biodegradability, biocompatibility, cationic property, and functional groups. Particularly, some intrinsic characteristics of chitosan equip it with high potential for facile preparation, flexible functionalization, and modification, which circumvent the defects of chitosan and account for extensive attempts in cancer therapy and theranostic. In this review, we first give a classifiable explanation of strategies in fabricating rationally-designed chitosan-based polymeric
nanomaterials for cancer therapy, which are categorized by the physical, chemical, and biological intrinsic characteristics of chitosan, respectively. Specifically, examples harnessing the cationic charge of chitosan are clarified, and the accompanied pH-responsive ability functions frequently are also mentioned. Besides, strategies toward the modification
of functional groups (amino and hydroxyl groups) in repeated glycosidic units of chitosan and their additional roles are also discussed here. Lastly, the biological superiority
of chitosan as an adjuvant or a ligand for glycoprotein and the application of chitosan-based polymeric nanomaterials in theranostic are summarized. Altogether, this review provides a comprehensive overview of recent advances in chitosan-based polymeric
nanomaterials for cancer therapy and theranostics from a brand new perspective.
Bioactive Compounds from Polar Regions: An Account of Chemical Ecology and Biotechnological
Applications
Authors: Singh Archana , Singh Keisham S. 
Published: June 2022

Abstract:
Organisms living in polar regions experience harsh environmental conditions. To cope and adapt to the extreme climatic conditions, the organisms produce specialized metabolites. The metabolites produced by polar organisms exhibit various biological activities and thus find application in the pharmaceutical, food and cosmetic industries. Numerous secondary metabolites have been isolated from polar organisms that exhibited interesting biological properties. With ongoing climate change and the opening up of the polar regions for resource exploration, it is important to realise the natural product potential and scope of the regions. This review describes a brief account of bioactive compounds reported from polar organisms along with their ecological perspective and biotechnological applications. We present a detailed overview of the chemicals structures of the compounds isolated from polar regions, which are grouped into usnic acid, MAAs, asterric acids, depsides, depsidones and psedodepsidones, alkaloids, polysaccharides and EPS. We have also discussed the ecological significance of the compounds, covering a general aspect as well as a specific account, wherever reported, along with bioactivities. The review covers the literature report from 2010 to 2020.
Addition of Mercury Causes Quenching of NIR Fluorescence Emission Spectra of a Photoactivatable PAiRFP1 Protein
Authors: Hassan Fakhrul , Khan Faez Iqbal , Juan Feng , Khan Abbas , Lai Dakun 
Published: June 2022

Background:Biliverdin (BV) containing far-red light photoactivatable near-infrared fluorescent protein (NIR-FP) named PAiRFP1 has been developed by directed molecular evolution from one bathy bacteriophytochrome of Agrobacterium tumefaciens C58 called Agp2 or AtBphP2. Usually, the fluorescence intensity of the NIR emission spectra of PAiRFP1 tends to increase upon repeated excitation by far-red light.Objective:This study aimed at exploring the role of PAiRFP1 and its mutants, such as V386A, V480A, and Y498H, as NIR biosensors for the detection of Hg2+ ions in the buffer solutions.Methods:In this study, we used PCR-based site-directed reverse mutagenesis, fluorescence spectroscopy, and molecular modeling approaches on PAiRFP1 and its mutants.Results:It was found that PAiRFP1 and its mutants experienced strong quenching of NIR fluorescence emission spectra upon the addition of different concentrations (0-3μM) of mercuric chloride (HgCl2).Conclusion:We hypothesized that PAiRFP1 and its variants have some potential to be used as NIR biosensors for the in vitro detection of Hg2+ ions in biological media. Moreover, we also hypothesized that PAiRFP1 would be the best tool to use as a NIR biosensor to detect Hg2+ ions in living organisms because of its higher signal-to-noise (SNR) ratio than other infra-red fluorescent proteins.
Association of SARS-CoV-2 Infection and Triple Negative Breast Cancer (TNBC) A Computational Illustrative Study
Authors: Vyshnavi A. M. Hima , Namboori P. K. Krishnan 
Published: June 2022

Background:Anticipating the correlation between SARS-CoV-2 infection and ‘triplenegative breast cancer (TNBC)’ remains challenging. It has been reported that people currently diagnosed with cancer have a higher risk of severe complications if they are affected by the viral infection. Cancer treatments, including chemotherapy, targeted therapies, and immunotherapy, may weaken the immune system and possibly cause critical lung damage and breathing problems. Special attention must be paid to the ‘comorbidity condition’ while estimating the risk of severe SARSCoV- 2 infection in TNBC patients. Hence the work aims to study the correlation between triplenegative breast cancer (TNBC) and SARS-CoV-2 using biomolecular networking.Methods:The genes associated with SARS CoV-2 have been collected from curated data in Bio- GRID. TNBC-related genes have been collected from expression profiles. Molecular networking has generated a Protein-Protein Interaction (PPI) network and a Protein-Drug Interaction (PDI) network. The network results were further evaluated through molecular docking studies followed by molecular dynamic simulation.Results:The genetic correlation of TNBC and SARS-Cov-2 has been observed from the combined PPI of their proteins. The drugs interacting with the disease's closely associated genes have been identified. The docking and simulation study showed that anti-TNBC and anti-viral drugs interact with these associated targets, suggesting their influence in inhibiting both the disease mutations.Conclusion:The study suggests a slight influence of SARS-CoV-2 viral infection on Triple Negative Breast Cancer. Few anticancer drugs such as Lapatinib, Docetaxel and Paclitaxel are found to inhibit both TNBC and viral mutations. The computational studies suggest these molecules are also useful for TNBC patients to control SARS-CoV-2 infection.
Sex-Related Differences Linked to Depression Disorders and Chronic Inflammation
Diseases in Nursing Shift Workers: An Expsloratory Multidimensional
Literature Review
Authors: Antonino Calabrò , Vitale Elsa , Bardone Lorenzo 
Published: June 2022

Objective:
The objective of this literature review is to explore how depression and inflammatory
conditions relate to gender among nurses working shifts.

Method:
Relevant studies available on the PubMed database over the past decade were consulted.
The main keywords were: “shift nurses”, “depression”, “gender Shift Nurses”, “Gender Role”,
“shift nurse”, “gender roles”, “Inflammation” and then, free terms were combined with the Boolean
AND operator. Inclusion and exclusion criteria had been formerly identified, and then, all the selected
studies were assessed according to the following criteria, good description, and appropriateness
of study design (objective and method), sample (sufficiently numerous, clarity of treatment
allocation criteria, absence of important bias), intervention, outcomes, statistical analysis, and clinical
relevance.

Results:
61 titles concerning research on inflammation were found. 28 titles were not taken into
account as doubles whilst 33 were selected by title and abstract; in addition, 28 were discarded
because they were not relevant to the objective or because they did not meet the inclusion criteria.
Out of the remaining 5, a further 2 were also discarded upon a careful analysis of the whole text:
they did not prove relevant to the research question. As for the research related to depression, the
research strategy highlighted 186 articles in the first place and then eliminated 165 of them either
because they were duplicates or on the grounds that they did not answer the research questions; 21
texts were thoroughly analyzed and, after a careful read, 4 studies were eventually incorporated in
this review.

Conclusion:
Since data available in the literature were inconsistent, it was difficult to establish that
all depression conditions could be associated with an increase in inflammation and vice versa and
that this condition was strictly connected to the female gender.
Edible Vaccine - An Effective Way for Immunization
Authors: Singhal Divyanshi , Mishra Rashmi 
Published: June 2022

Abstract:
Edible vaccines are cost-effective, easy to take, storable as well as bio friendly. If we take it orally, it proves it is capable agents for lessening the occurrence of several diseases like HPV, Norwalk as well as Polio. They are gotten by incorporate a specific quality which is of our enthusiasm into the plant, which creates the attractive encoded protein. These particular encoded proteins furnish the mucosal movement alongside resistance. There are different food items that are utilized as elective specialists for injectable antibodies, for example, wheat, rice, bananas, lettuce, potatoes, tomatoes. In this way, they defeat all the issues related with conventional antibodies and it demonstrates that palatable immunizations is best substitutes to the customary antibodies.
Correlation of the Oral Health Scoring-based Pregnant Oral Self-Care – package (POSC-p) Model with the Motivation to Seek Oral Health Treatment in Pregnant Women
Authors: Suwargiani Anne Agustina , Aripin Dudi , Arief Erry Mochamad , Djustiana Nina , Usri Kosterman , Tjahajawati Sri , Cahyanto Arief , Widyaputra Sunardhi , Susilawati Sri , Abdulkadir Rahimah 
Published: June 2022

Background:
Uncomprehensive oral health evaluation instruments and measurement and the low motivation for seeking dental and oral treatment for pregnant women; all require comprehensive measurement instruments that will increase the motivation for seeking oral health treatment for pregnant women. POSC-p model was developed for the Oral Health Scoring (OHS) to assess pregnant women's perceived needs, clinical examination, and salivary state.

Objectives:
The research objective was to analyse the correlation between the POSC-p model with the motivation for seeking oral health care in pregnant women.

Methods:
Cross-sectional research was conducted by a non-probability sampling technique using the consecutive sampling method. The sample size was determined based on the correlation analysis sample size calculation formula. The study variables were POSC-p model built with three dimensions; POSC-p score section 1 was felt needs, POSC-p score section 2 was normative needs, and POSC-p score section 3 was saliva condition. In addition, motivation to seek treatment with intrinsic and extrinsic motivation dimensions. All data were analysed using the Spearman rank correlation test.

Results:
A significant correlation was found between the POSC-p model with intrinsic and a combination of treatment-seeking motivation (p=0.026); a combined score of the POSC-p model with intrinsic (p=0.008) and a combination of treatment-seeking motivation (p=0.032).

Conclusion:
There is a correlation between the POSC-p with motivation for seeking oral health treatment in pregnant women.
KASUS SCALY FACE PADA KAKATUA PUTIH (Cacatua alba) DI TAMAN KONSERVASI MADIUN UMBUL SQUARE
Authors: Endah Anggraeni Henny , Sulistian Miftakhul , Aprilia Winantika 
Published: June 2022

Scaly face is an infestation by burrowing mites Knemidocoptes pilae. It is frequently encountered in birds, where the mite affects featherless tracts, most commonly the beak, and eyelids. Losses due to ectoparasite infestation in birds was decreased appetite, hair loss, hyperkeratosis, alopecia, itching and death. The purpose of writing a case study is provides information about the management of the scaly face in the white parrot (Cacatua alba) in the Madiun Umbul Square Conservation Park. East Java, Indonesia, on 20 July - 20 August 2020. Observations were directly, by assisting in handling and treatment in isolation cages. A white parrot weighs 600 grams, from Balai Konservasi Sumber Daya Alam (BKSDA) showed hair loss and keratosis around the eyes and. Handling bird placement in isolation cages, skin scraping examination, found Knemidocoptes pilae, treatment with 0.02 ml of 1% ivermectin and 0.1 ml of Vetadryl® subcutaneously 3 times on 30 July, 10 and 17 August 2020. The results of treatment show healing such as appetite increases, keratosis disappears, and fine hairs grow around the eyes.
Clasificación de enfermedades y condiciones periodontales y periimplantarias 2018. Primera parte
Authors: Vargas Casillas Ana Patricia , Yáñez Ocampo Beatriz Raquel 
Published: June 2022

Las academias de periodontología se reúnen en determinados mo- mentos para revisar los avances científicos y, acorde con éstos, realizan cambios a la clasificación de las enfermedades y condicio- nes periodontales. La clasificación de enfermedades periodontales del año 1999 estuvo vigente durante 18 años, por lo que en 2017 se realizó un taller mundial copatrocinado por la Academia Americana de Periodontología (AAP) y la Federación Europea de Periodontolo-gía (EFP, por sus siglas en inglés), donde expertos periodontales de todo el mundo se reunieron para actualizar y presentar una nueva clasificación. Se dividieron en cuatro grupos de trabajo consistentes en: I. Salud periodontal, enfermedades y condiciones gingivales; II. Formas de periodontitis; III. Manifestaciones periodontales de las enfermedades sistémicas y condiciones del desarrollo y adquiridas; y IV. Enfermedades y condiciones periimplantarias. La nueva clasi- ficación publicada en 2018 presenta grandes cambios como: la de- finición de salud periodontal para su detección tanto en situaciones clínicas como con fines epidemiológicos, y la de periodonto intacto y reducido; la exclusión de la periodontitis crónica y agresiva, inclu- yéndolas en una sola periodontitis, determinada a través de la pér- dida de inserción y ósea, categorizada por estadios (I, II, III y IV) y grados de progresión (A, B, C); y la incorporación de enfermedades y condiciones periimplantarias. La nueva clasificación busca ser útil, práctica, flexible, con definiciones de casos y criterios de diagnósti- co para apoyar al clínico en el tratamiento de sus pacientes, y per- mitir a los clínicos e investigadores de cualquier área comunicarse con un lenguaje común. El objetivo del presente trabajo es presen- tar en dos partes las principales definiciones y parámetros de cada concepto de la nueva clasificación para el estudiante y dentista de la práctica general. En esta primera parte, se abordará la sección I (Salud periodontal, enfermedades y condiciones gingivales) y lasección II (Formas de periodontitis).
COVID-19 y úlceras orales: ¿un signo cada vez más frecuente?
Authors: Rocafuerte-Acurio Marco Antonio 
Published: June 2022

Diversos estudios sugieren que los signos y síntomas más comunes de la infección por SARS-CoV-2 son dolor de cabeza, dolor de garganta, hiposmia, hipogeusia, diarrea, disnea y, en casos graves, neumonía. Sin embargo, uno de los aspectos escasamente documentados es la semiología a nivel de la cavidad oral. Esto podría ocurrir debido a que los odontólogos en diversas partes del mundo no quieren atender a pacientes infectados por SARS-CoV-2 por el alto riesgo de contagio a causa del íntimo contacto con la sali- va y las glándulas salivales mayores, en las cuales se encuentran grandes cantidades de receptores ECA-2 que van a facilitar la entrada del virus a la célula, y por ser una zona predilecta para la fijación de las proteínas de la espícula (spike) del coronavirus.
A comparative prospective study in the management of Helicobacter pylori infection using Lactobacillus reuteri Vs conventional therapy
Authors: Hassan Syed Ibrahim , Baleeqh Uddin Mohammed , Kaunaine Mohd Ehtesham , Sultana Sumayya , Samreen Syeda Aleena , Mohiuddin Mohd 
Published: June 2022

Background: Helicobacter pylori (H. pylori) infection has become a remarkable worldwide health problem. The eradication of H. pylori has become a challenge. Probiotics have proven beneficial in reducing the side effects and increases patient compliance. Lactobacillus reuteri (L. reuteri) is frequently used probiotic and considered safe for human consumption. The aim of this study was to compare the effectiveness of a probiotic and conventional antibiotic triple therapy in the management of H. pylori infection.
Methods: This was a prospective observational study carried out for a period of six months. Patient data were extracted from their medical records. Treatment outcome was evaluated based on the report of Rapid Urease Test (RUT). Symptoms were assessed using Gastrointestinal Symptom Rating Scale (GSRS). Descriptive statistics were used to summarize patient characteristics. T-test, chi square test and one way ANOVA were used wherever appropriate.
Results: A total of 105 patients with confirmed H. pylori infection were included, of which 42% were males and 58% were females. The mean age of three group patients were 38.03±10.68, 34.00±13.36 and 36.11±13.37 years. Eradication rate noted in Lactobacillus reuteri only treatment was 86%, eradication rate noted in Lactobacillus reuteri+ ppi was 86% and in antibiotic group was 92%. Patients with three different treatments have shown significant improvement in gastrointestinal symptoms (p < 0.001).
Conclusion: The overall data suggest that L. reuteri is recommended for a better eradication rate and reduced gastrointestinal symptoms. Though conventional triple therapy of H. pylori has shown an increased eradication rate and significant improvement in gastrointestinal symptoms, there was no great difference when compared with L. reuteri treated patients.
Keywords: H. pylori, Triple therapy, L. reuteri, Eradication, Gastrointestinal symptoms
A Review on Quality by Design Approach in Analytical Methods
Authors: Katekar Vinayak , Sangule Dipali , Bhurbhure Om , Ingle Priyanka , Dhage Shivprasad , Jadhav Krushna 
Published: June 2022

Quality by Design (QbD) is a systematic approach to development that begins with predefined objectives for a product, process understanding, and process control based on knowledge and quality risk management. All conventional methods may fail to the intended purpose during method development and validation. In a QbD approach, the impact and interactions between critical method variables are understood using a Design of Experiments (DOE) approach, which gives multivariate analysis and modeling leading to the consistent quality of drug products. QbD tools like risk assessment and design of experiments, enable better quality to be incorporated into the analytical method and facilitate prior understanding and identification of variables affecting method performance. The main objective of the present review article is to describe different steps involved in method development by the QbD approach for analytical method development. The QbD Approach for method development comprises various steps that include defining method intent, performing experimental design, evaluating experimental results, selecting proper method conditions, and performing risk assessment with changing analytical parameters and conditions for evaluation. The purpose of analytical QbD is to attain quality in measurement.
Keywords: Quality by Design (QbD), Design of Experiments (DOE), Critical attributes
Description of Mother's Knowledge Level about BCG Immunization in Infants Age 0-2 Months at Posyandu, Kebun Pala Village, Makassar, East Jakarta
Authors: Wija Ida Bagus Eka Utama , Ronny , , Prihantini Nur Nunu 
Published: June 2022

TB is considered the fourth leading cause of death. Pediatric TB is an essential factor in developing countries because the population of children aged younger than 15 years old is 40%-50% of the total population. At least 500,000 children are infected by TB annually. Globally, TB kills 200 children every single day and contributes to the death of 70,000 children annually. Immunization is one of the measures in the prevention of TB transmission. BCG vaccination has been playing the role of one of the WHO strategies since 1921 to eradicate TB problems, especially in developing countries, including Indonesia, and more than 3 billion doses of BCG vaccine have been distributed worldwide. This research aims to describe the level of mothers' knowledge regarding the BCG immunization among 0-2 months old infants in Posyandu (pre- and postnatal health care and information for women and children under five years) Kelurahan Kebun Pala Makassar, East Jakarta. The researcher used univariate analysis with the cross-sectional approach in this descriptive epidemiological research. The questionnaire that consisted of 21 questions was the primary data source for this research. The questionnaire was distributed on February 23, 2018. The researcher involved 50 respondents as the sample of the research population. Based on the analysis, the researcher concludes that 24,0% of respondents have a good level of knowledge, while the remaining respondents (76,0%) have an adequate level of expertise.
Keywords: TB, BCG Immunization, Knowledge