bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 3-Item Measure of Digital Health Care Literacy: Development and Validation Study
Authors: Nelson Lyndsay A , Pennings Jacquelyn S , Sommer Evan C , Popescu Filoteia , Barkin Shari L 
Published: March 2022

Background
With increased reliance on digital health care, including telehealth, efficient and effective ways are needed to assess patients’ comfort and confidence with using these services.

Objective
The goal of this study was to develop and validate a brief scale that assesses digital health care literacy.

Methods
We first developed an item pool using existing literature and expert review. We then administered the items to participants as part of a larger study. Participants were caregivers of children receiving care at a pediatric clinic who completed a survey either on the web or over the telephone. We randomized participants into development and confirmatory samples, stratifying by language so that exploratory factor analysis and confirmatory factor analysis could be performed with separate samples of participants. We assessed the scale’s validity by examining its associations with participants’ demographics, digital access, and prior digital health care use.

Results
Participants (N=508) were, on average, aged 34.7 (SD 7.7) years, and 89.4% (454/508) were women. Of the 508 participants, 280 (55.1%) preferred English as their primary language, 157 (30.9%) preferred Spanish, and 71 (14%) preferred Arabic; 228 (45%) had a high school degree or less; and 230 (45.3%) had an annual household income of <US $35,000. Using exploratory factor analysis, 3 items were retained in a reduced scale with excellent reliability (Cronbach α=.90) and a high variance explained (78%). The reduced scale had excellent fit, with factor loadings between 0.82 and 0.94. All fit statistics exceeded the criteria for good fit between the proposed factor structure and the data. We refer to this scale as the Digital Health Care Literacy Scale. The scale was positively associated with education (ρ=0.139; P=.005) and income (ρ=0.379; P<.001). Arabic speakers had lower scores than English (P<.001) and Spanish speakers (P=.02), and Spanish speakers had lower scores than English speakers (P<.001). Participants who did not own a smartphone (P=.13) or laptop computer (P<.001) had lower scores than those who owned these devices. Finally, participants who had not used digital tools, including health apps (P<.001) and video telehealth (P<.001), had lower scores than those who had used these tools.

Conclusions
Despite the potential for digital health care to improve quality of life and clinical outcomes, many individuals may not have the skills to engage with and benefit from it. Moreover, these individuals may be those who already experience worse outcomes. A screening tool such as the Digital Health Care Literacy Scale could be a useful resource to identify patients who require additional assistance to use digital health services and help ensure health equity.
Glossário de Administração em Libras: discussão sobre coleta, registro e publicização de sinais-termo
Authors: Friedrich Márcio Aurélio , Lebedeff Tatiana Bolivar 
Published: March 2022

O trabalho apresenta a produção de um glossário em Língua Brasileira de Sinais – Libras, trazendo o par linguístico Língua Portuguesa e Libras, tendo como foco a produção de sinais-termo específicos da área da Administração. Utiliza-se o conceito de sinal-termo de Faulstich (2012). A investigação segue, como paradigma, o caminho de pesquisa lexicográfica de Libras de Martins (2012) e Martins (2018), que é o de coletar, registrar e publicizar os sinais ou sinais-termo já utilizados pela comunidade surda que, neste trabalho, compreendeu usuários de Libras do RS e do PR. Ou seja, este trabalho não teve como propósito criar e/ou validar novos sinais. Este estudo deu-se a partir de uma carência lexical de termos específicos no processo de tradução das aulas do curso de Administração da UFPel, que foi relatada por um acadêmico surdo, bem como pelos tradutores intérpretes de Libras da instituição, os quais sempre precisaram optar por outras estratégias de tradução, sejam elas: a soletração em alfabeto manual ou a combinação de sinais. Os procedimentos para a produção do glossário envolveram: 1) entrevista com estudante surdo para a coleta de termos em português para os quais não havia sinais-termo; 2) coleta dos sinais-termo com dez colaboradores surdos já formados ou ainda estudantes de Administração; 3) organização de um questionário no qual foram apresentados os sinais-termo coletados, e suas variações, para votação dos próprios colaboradores; 4) produção de fichas terminológicas; 5) publicização dos sinais-termo. Como resultados foram coletados 102 sinais-termo em Libras de 25 termos em Língua Portuguesa. Para cada sinal-termo foi produzida uma ficha terminológica. Buscou-se, nas fichas, propor mais acessibilidade e novas opções de busca como a utilização de QR Code e a disponibilidade de link no YouTube, considerando a característica visuoespacial da Libras.
“COPULE-SE”: proposta de atividades didáticas a partir do léxico do conto “Os chapéus transeuntes”, de Guimarães Rosa
Authors: Silva David Lopes da 
Published: March 2022

O presente ensaio parte da estória “Os chapéus transeuntes”, de Guimarães Rosa, que oferece o material linguístico a ser utilizado em duas possibilidades de atividades didáticas. Na primeira, é fornecida uma listagem de palavras inusuais ou neológicas encontradas no conto. Na sequência, uma outra lista (seguimos procedimento rosiano, que, como se sabe, adorava listas), agora de palavras dicionarizadas, tenta distinguir as nuances de expressões que gravitam ao redor do tema central do conto, a “soberba”, com o intuito de forçar a atenção ao detalhe e perceber que cada termo, por mais que seja aparentado a outros, é singular. A metodologia do artigo é descritiva, apresentando as duas sugestões de propostas didáticas, junto com seu material para aplicação (as listas). Já a metodologia das atividades é aberta, de acordo com o planejamento de cada professor, a partir das diretrizes expostas no artigo. O público-alvo dos dois exercícios pode ser de discentes do Ensino Médio ou mesmo de cursos de graduação em Letras. Como resultado, espera-se que o aluno se aproxime do autor considerado "difícil" através de um viés incomum que pode suavizar esse primeiro contato. Para além disso, despertar sua criatividade linguística latente (a partir da atividade um), bem como ampliar seu vocabulário de forma sistemática (com a atividade dois).
Aquisição de vocabulário e o uso de dicionário escolar português-inglês
Authors: Polizer Alex Sandro Da Silva , Marques Giseli Sampaio de Oliveira , Zacarias Regiani Aparecida Santos 
Published: March 2022

Este artigo tem por tema o ensino de vocabulário por meio da utilização do dicionário escolar português-inglês e destaca a importância do uso efetivo de palavra/expressão nova para garantir a sua aquisição. Para tanto, utilizaremos como referencial teórico Alves (1988), Biderman (1996, 1998), Jacobs (2002), Krieger (2006), Zacarias (2011), Lima (2014) e Fragoso (2018). O objetivo é apresentar o dicionário português-inglês como meio para oportunizar a ampliação do repertório lexical de língua inglesa no contexto escolar. Além das reflexões teóricas, o artigo apresenta uma sequência didática para ensino de vocabulário e uso do dicionário dividida em três momentos. O primeiro momento consiste em despertar o interesse dos alunos por meio do levantamento do conhecimento prévio. O segundo consiste em apresentar aos alunos as partes dos dicionários, quais informações são oferecidas, e como elas estão disponibilizadas no dicionário Longman; o terceiro momento traz sugestões para que o aluno faça uso efetivo da aprendizagem de vocabulário, como listas das palavras que for aprendendo, para ter fácil acesso em revisões e consultas pessoais. Somam-se à questão novas perspectivas a serem contempladas em obras lexicográficas voltadas para a educação. Espera-se colaborar e promover o efetivo uso dos dicionários português-inglês em sala de aula e motivar o seu uso em ambiente extraclasse, incentivando o aprendizado contínuo e autônomo, como preconiza a BNCC (2017). Da mesma forma, espera-se contribuir para reflexões acerca de melhorias das obras lexicográficas na perspectiva do usuário aprendiz brasileiro.
Overview of Host Defense Peptides with Promising Anti-Breast Cancer Activity
Authors: Zornic Sanja , Lukovic Bojana , Jevtovic Andra , Dimitrijevic Jelena D. , Markovic Bojana Simovic , Pantic Jelena , Radosavljevic Gordana D. , Arsenijevic Nebojsa 
Published: March 2022

Abstract
Breast cancer is the leading cause of death among women worldwide. The main limitations of conventional anti-cancer therapy, including breast cancer treatment, are side effects and the development of resistance to chemotherapeutics. Host defense peptides (HDPs) are bioactive compounds of innate immunity isolated from almost all living organisms, which exhibit wide range of biological activities. This review focuses on the anti-cancer effects of HDPs and their therapeutic potential against breast cancer. Numerous HDPs from different sources, including mammalian and amphibian origin, and their chemically modified analogues, exert the spectrum of anti-cancer activities. These effects include direct disruption of cancer cell membrane, induction of apoptosis, inhibition of angiogenesis and cancer cell proliferation, but also the modulation of anti-cancer immune response. Selected examples of HDPs of different origin and their anti-breast cancer capacities have been reviewed. Conclusively, due to their anti-cancer effects accompanied by substantial selectivity for cancer cells and low toxicity for normal cells, HDPs have been widely recognized as possible therapeutic agents.
Characteristics of Hospitalized COVID-19 Patients in Sumadija District in 2020
Authors: Mihailovic Natasa , Djordjevic Ivana Mitrovic , Uskokovic Nikola , Miljanovic Ana , Zdravkovic Ljiljana , Bukumira Slavica , Bajic Biljana 
Published: March 2022

Abstract
The number of hospitalized COVID patients varies in accordance with the waves of the pandemic. The aim of the study was to examine the characteristics of hospitalized COVID-19 patients and predictors of in-hospital died with special reference to the importance of comorbidity. A retrospective cohort study that included all COVID patients hospitalized at the Clinical Center Kragujevac in 2020. The data contained in the Hospitalization Report are described, and the predictors of hospital mortality are defined by binary logistic regression. 1336 COVID patients were hospitalized. The average age of the hospitalized patients was 58.1 ± 16.5 years, 2/3 of them were males. The largest number of hospitalized patients live in Kragujevac - 62.8%. During hospitalization, 19.4% (n = 206) of patients died, who were on average 13 years older (t = 14.13, df = 504.3, p <0.01), and stayed in the hospital 2 days shorter (Z = -5.36, p <0.01) when compared to discharged patients. 86.5% (n = 1155) of hospitalized patients had comorbidities, most often hypertension and other heart diseases, diabetes mellitus and renal failure. Statistically significant predictors of the lethal outcome of hospitalization were patients’ age (OR = 0.94 95% CI = 0.93-0.95), residence (OR = 0.84, 95% CI = 0.75-0.95), length of hospitalization (OR = 1.06, 95% CI = 1.04-1.09) and the presence of comorbidity as the strongest predictor (OR = 5.31, 95% CI = 2.37-11.89). COVID Patients with comorbidities require special attention because comorbidities affect the outcome of hospitalization.
Comparison of radiologic response criteria as predictors for refractoriness and survival to transarterial chemoembolization among hepatocellular cancer: Outcomes from a Southeast Asian cohort
Authors: Kuhn Rudolf V. , Ignacio Glenn Marc G. , Jamias Jade D. 
Published: March 2022

Objectives:
Radiologic response helps select patients with hepatocellular carcinoma who may become refractory after repeated sessions of transarterial chemoembolization (TACE). The utility of the various criteria in assessing radiologic response and survival is, however, poorly defined. This study aimed to compare the modified response evaluation criteria in solid tumors and Choi criteria as well as identify other predictors of overall survival and refractory disease of HCC patients undergoing repetitive TACE.

Material and Methods:
The radiologic response, as well as clinical and laboratory characteristics of 39 patients treated with repetitive conventional TACE from January 2012 to January 2019, were analyzed in a retrospective cohort.

Results:
The median overall survival of patients was 23.2 months and overall mortality was 36%. Multivariate Cox regression analysis revealed that progressive disease (PD) using Choi criteria (HR = 5.47, CI 1.15–25.99, P = 0.033) and enhancement on follow-up CT (computed tomography) imaging (HR = 1.98, P = 0.034) were independent risk factors for poor survival as were Child-Pugh score (Hazard ratio = 3.47, P = 0.044), AST (HR = 7.6, P = 0.021), tumor size (HR = 5.47, P = 0.033), and neutrophil-lymphocyte ratio (HR = 1.25, P = 0.049). Multivariate analysis also showed that ALT (P = 0.005), enhancement (P = 0.003), Child-Pugh score (P = 0.010), and PD using Choi criteria (P = 0.022) were predictive of TACE refractoriness/failure.

Conclusion:
Predictors for poorer survival and TACE failure/refractory disease were identified. Radiologic response using the Choi criteria and persistent contrast enhancement on radiologic follow-up is ominous imaging signs on patient surveillance and should be included in a rational treatment strategy and the decision to switch therapy.
Pathogenetic continuum of coagulopathies and the complexity of their therapy in COVID-19
Authors: Харченко Е.П. 
Published: March 2022

В аспекте вырисовывающейся мозаики потенциальных механизмов патогенеза COVID-19 вызываемые им коагулопатии представляются больше как проявление патогенетического континуума, развертывающегося во времени и вовлекающего множество разных участников. Иллюстрацией этого служит признание активной роли системы комплемента в иммуновоспалительном патогенезе коагулопатий при COVID-19. Системы комплемента и гемостаза тесно связаны по происхождению в эволюции и функционально. Активация их взаимозависима. При нарушенной регуляции эта взаимная коактивация обеих систем может иметь тенденцию формирования патологического порочного круга, осложняя течение COVID-19 и его терапию. Связь активации комплемента с тяжелыми формами COVID-19, реверсирование ингибиторами комплемента тромботической микроангиопатии, снижение остроты легочных поражений при COVID-19 ингибированием компонентов комплемента побуждают использовать иммунотерапию при нарушениях гемокоагуляции с учетом ее возможных побочных эффектов.
In aspect of displaying the mosaic of potential COVID-19 pathogenesis mechanisms, its coagulopathy more seems as the manifestation of pathogenicity continuum with participation of many factors. It is illustrated by confirming an active role of the system complement in the immunoinflammatory pathogenesis of coagulopathy in COVID-19. The complement system and hemostasis are structurally and evolutionary related and also are functionally closely connected. Their activation is mutually dependent. In case of disturbed regulation the mutual coactivation can have the potential of becoming a pathologic vicious cycle complicating COVID-19 course and its therapy. The relationship of complement activation and severe COVID-19 forms, the reversion of thrombotic microangiopathy by complement inhibitors, decreasing acute lung lesions by inhibiting complement serve as indication for using immunotherapy in case of coagulopathy in COVID-19 taking into account its side effects.
Methodology for hemodynamic functions study in severe arthrosis of knee and hip joints
Authors: Кузник Б.И. , Смоляков Ю.Н. , Давыдов С.О. , Партс Д.С. , Андреев Н.К. 
Published: March 2022

Введение. Течение постоперационного периода при эндопротезировании суставов во многом определяется состоянием гемодинамики в зоне пораженного органа. Поэтому особенно важно выявить зону регистрации гемодинамических функций, наиболее объективно отражающую состояние микроциркуляции в пораженном суставе. Цель исследования: сравнительная оценка гемодинамических показателей межслоевого сдвига в различных проекциях микроциркуляторного русла до и после оперативного вмешательства. Материалы и методы. Проведено обсервационное проспективное когортное исследование. Обследовано 90 больных (53 с артрозом тазобедренного сустава и 37 с артрозом коленного сустава в возрасте 60,8 ± 9,2 лет) в предоперационном периоде и на 6‑й день после эндопротезирования сустава. Регистрация микроциркуляторных гемодинамических индексов межслоевого сдвига, полученных методом лазерной спекл-интерферометрии, осуществлялась одновременно с пальца и зон проекции здорового и пораженного сустава. Результаты. Обнаружено, что наиболее значительные сдвиги со стороны гемодинамических и осцилляторных индексов наблюдаются как в до-, так и постоперационном периоде и наиболее выражено проявляются в зоне проекции пораженного сустава. Заключение. Рекомендуется у больных с артрозами как в до-, так и постоперационном периоде определять гемодинамические функции в области проекции пораженного сустава. Предлагаемый метод помогает оценивать эффективность и корригировать применяемую терапию в постоперационном периоде.
Background. The postoperative period in arthroplasty is largely determined by hemodynamics state in the area of the affected organ. That is why it is especially important to identify the area of registration of hemodynamic functions, which objectively reflects microcirculation state in the affected joint. Objectives: comparative assessment of hemodynamic parameters of the interlayer shear in various microvasculature projections before and after surgery. Patients/Methods. An observational prospective cohort study was performed in 90 patients (53 with arthrosis of the hip joint, 37 with arthrosis of the knee joint), in the preoperative period and on the 6th day after hip or knee joint replacement. The average age of patients was 60.8 ± 9.2 years. Registration of hemodynamic indices of interlayer shear obtained by laser speckle interferometry was carried out simultaneously from the finger and the projection zones of healthy and affected joint. Results. It was found that the most significant changes of hemodynamic and oscillatory indices were observed both in the pre- and postoperative period, most pronouncedly manifested in the projection zone of the affected joint. Conclusions. It is recommended for patients with arthrosis to determine hemodynamic functions both in the pre- and postoperative period in the projection area of the affected joint. The proposed methodology helps to assess the effectiveness and correct the applied therapy in the postoperative period.
Anticoagulant treatment for severe COVID-19 with high bleeding risk.
Authors: Колесников В.В. , Ройтман Е.В. , Леонов А.А. 
Published: March 2022

Авторами приведен анализ лечения 16 пациентов, проходивших лечение в 5 инфекционных госпиталях ГБУЗ СО ТГКБ № 5 за период с 12.03.2020 по 31.08.2021 по поводу тяжелого течения новой коронавирусной инфекции (НКИ) COVID-19, осложнившейся кровотечениями на фоне антикоагулянтной терапии. Все пациенты получали лечебные дозы антикоагулянтов — низкомолекулярных гепаринов (НМГ). На примере клинических случаев показано, что основными причинами геморрагических осложнений у пациентов с тяжелым течением НКИ COVID-19 были избыточая степень антикоагуляции, инвазивные манипуляции и механические повреждения тканей (прон-позиция). Таким образом, назначение антикоагулянтной терапии пациентам с тяжелым течением НКИ COVID-19, в том числе с признаками развития полиорганной недостаточности, сопряжено с повышением риска развития кровотечений. Данное обстоятельство ультимативно требует предварительной оценки соотношения рисков развития тромботических и геморрагических осложнений, а также принимать во внимание значения клиренса креатинина (СКФ) для исключения кумуляции эффекта НМГ. Подбор дозы НМГ или нефракционированного гепарина (НФГ) должен сопровождаться оценкой эффекта антикоагулянтов по данным определения анти-Ха активности, которая не должна превышать 1,0 ЕД/мл. Для снижения риска развития геморрагических осложнений у пациентов с тяжелым течением НКИ COVID-19 возможно использовать комбинацию механических и фармакологических антитромботических средств, в том числе метод перемежающейся пневматической компрессии сосудов нижних конечностей.
Anticoagulant therapy in severe COVID-19 raises bleeding risk. We considered 16 medical stories of inhospital patients with severe COVID-19 complicated with bleeding. Anticoagulant treatment with mainly low molecular weight heparins (LMWHs) in therapeutic doses was performed for all of them. Main revealed causes for hemorrhagic complications were invasive interventions, and tissue compression due to prone position, and an excessive anticoagulation with anti-Xa > 1.0 ME/mL. Anticoagulant excess was developed because of what the creatinine clearance was not considered for LMWHs dosing. Obtained results show the thrombotic/bleeding risk ratio together with renal function should be evaluated mandatory before anticoagulant starting in patients with severe COVID‑19. In such patients LMWHs doses have to be adjusted so that the anti-Xa don’t exceed 1.0 ME/mL. With caution we guess joint pharmacological and mechanical (including the intermittent pneumatic compression) antithrombotic prophylaxis is able to lower bleeding risk in patients with severe COVID-19.
Ampullar aneurysm of the popliteal vein. Recurrent pulmonary embolism. A rare clinical case of surgical treatment
Authors: Кордзахия Г.Э. , Янушко В.А. , Климчук И.П. , Комиссаров В.В. 
Published: March 2022

Мешковидная аневризма подколенной вены (АПВ) является редким, но опасным для жизни заболеванием. На сегодняшний день известно более 200 случаев с такой патологией. Ранняя диагностика данного заболевания чрезвычайно важна, поскольку оно является причиной тромбоэмболии легочной артерии (ТЭЛА) у пациентов, несмотря на предшествующую антикоагулянтную терапию. Основным методом диагностики АПВ является ультразвуковое исследование. Проведение компьютерной томографии с контрастированием рекомендовано в качестве дополнительного метода диагностики. Основной метод лечения — оперативное вмешательство. Впервые АПВ была обнаружена Мэйем и Нисслом в 1968 г. Представлен редкий клинический случай АПВ, осложненной тромбозом просвета и многократной рецидивирующей ТЭЛА. Редкость аневризм глубоких вен нижних конечностей, высокая вероятность развития их тромбоза и ТЭЛА, в том числе рецидивирующей, послужили основанием для публикации результата оперативного лечения.
Ampullar aneurysm of the popliteal vein (APV) is a rare but life-threatening disease. To date, more than 200 cases with this pathology are known. Early diagnosis of this disease is extremely important, since it is the cause of pulmonary embolism (РЕ) in patients, despite previous anticoagulant therapy. The main method of APV diagnosing is ultrasound examination. CT scan with contrast is recommended as an additional diagnostic method. The main method of treatment is surgical intervention. For the first time, APV was discovered by May and Nissl in 1968. A rare clinical case of APV complicated by lumen thrombosis and multiple recurrent PE is presented. The rarity of deep vein aneurysms of the lower extremities, the high probability of their thrombosis and PE, including recurrent ones, served as the basis for the publication of surgical treatment results.