bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable development of rural areas: a dynamic model in between tourism exploitation and landscape decline
Authors: Iannucci Gianluca , Martellozzo Federico , Randelli Filippo 
Published: July 2022

AbstractThis work investigates how to prevent sustainable tourism from turning into over-tourism dynamics. As a matter of fact, the former has shown to be capable of bringing profit to traditional rural activities (i.e. agriculture), the tourism sector, the environment and the cultural heritage of a region; whereas the latter, more often than not, harms and brings detriment to the natural landscape. Hereof, landscape heritage is a fundamental resource at the base of both rural tourism (RT) and traditional rural activities, and it is reasonable that to adequately support RT a certain degree of built-up growth (i.e. new accommodation facilities and cognate areas) is somewhat needed. However, we want to problematize that these dynamics shall be carefully calibrated and appropriately regulated in a non-conflictual way. We modeled that: (i) land can be either devoted to RT-hosting facilities or agriculture; (ii) RT impacts landscape resources more harmfully, thus diminishing profitability of both sectors. We also posit a policy instrument to preserve landscape resources, financed through RT revenues. The analysis shows that if no policy is applied, over-RT is ineluctable. Conversely, with such a policy instrument it is possible to determine an economic space where all rural economic activities peacefully coexist, and landscape impacts are minimized.
Asymptotic Expansion of the Elastic Far-Field of a Crystalline Defect
Authors: Braun Julian , Hudson Thomas , Ortner Christoph 
Published: July 2022

AbstractLattice defects in crystalline materials create long-range elastic fields which can be modelled on the atomistic scale using an infinite system of discrete nonlinear force balance equations. Starting with these equations, this work rigorously derives a novel far-field expansion of these fields. The expansion is computable and is expressed as a sum of continuum correctors and discrete multipole terms which decay with increasing algebraic rate as the order of the expansion increases. Truncating the expansion leaves a remainder describing the defect core structure, which is localised in the sense that it decays with an algebraic rate corresponding to the order at which the truncation occurred.
Degradation Reduces Microbial Richness and Alters Microbial Functions in an Australian Peatland
Authors: Birnbaum Christina , Wood Jennifer , Lilleskov Erik , Lamit Louis James , Shannon James , Brewer Matthew , Grover Samantha 
Published: July 2022

Abstract
Peatland ecosystems cover only 3% of the world’s land area; however, they store one-third of the global soil carbon (C). Microbial communities are the main drivers of C decomposition in peatlands, yet we have limited knowledge of their structure and function. While the microbial communities in the Northern Hemisphere peatlands are well documented, we have limited understanding of microbial community composition and function in the Southern Hemisphere peatlands, especially in Australia. We investigated the vertical stratification of prokaryote and fungal communities from Wellington Plains peatland in the Australian Alps. Within the peatland complex, bog peat was sampled from the intact peatland and dried peat from the degraded peatland along a vertical soil depth gradient (i.e., acrotelm, mesotelm, and catotelm). We analyzed the prokaryote and fungal community structure, predicted functional profiles of prokaryotes using PICRUSt, and assigned soil fungal guilds using FUNGuild. We found that the structure and function of prokaryotes were vertically stratified in the intact bog. Soil carbon, manganese, nitrogen, lead, and sodium content best explained the prokaryote composition. Prokaryote richness was significantly higher in the intact bog acrotelm compared to degraded bog acrotelm. Fungal composition remained similar across the soil depth gradient; however, there was a considerable increase in saprotroph abundance and decrease in endophyte abundance along the vertical soil depth gradient. The abundance of saprotrophs and plant pathogens was two-fold higher in the degraded bog acrotelm. Soil manganese and nitrogen content, electrical conductivity, and water table level (cm) best explained the fungal composition. Our results demonstrate that both fungal and prokaryote communities are shaped by soil abiotic factors and that peatland degradation reduces microbial richness and alters microbial functions. Thus, current and future changes to the environmental conditions in these peatlands may lead to altered microbial community structures and associated functions which may have implications for broader ecosystem function changes in peatlands.
Newly developed cement–ground granite scraps composite for solidification/stabilization of radioactive wastes: characterization and evaluation of the mechanical durability
Authors: Eskander Samir B. , Bayoumi Talat A. , Tawfik Magda E. , Mansour Hazem 
Published: July 2022

AbstractThe core objective of the present study is to develop an added value cement–granite composite (CGC) based on granite (G) scraps and Ordinary Portland Cement (OPC). The granite scraps were collected, washed, ground, sieved, and the finest powder was used as an inorganic admixture for developing the CGC. Plain water was added to the granite–cement powder and thoroughly mixed. The obtained pastes were casted for 28 days prior to their physical, structural, thermal characterizations and their mechanical evaluation. Factors assumed, mostly, to affect the final properties of the CGC blocks, e.g. granite/cement and water: cement ratios were studied. The reached monolith cement–granite composite has many advantages, e.g. lower density, very low water absorption percentage, acceptable compressive strength values and significant radiation and thermal stability. Based on the experimental data reached it could be stated that: for its economical advantages, where the one of its basic components is a waste. In addition to the acceptable mechanical traits of the developed composite, it can be candidate properly as an inert matrix for some radioactive wastes containment, for application in many field including: construction sector (interior and exterior of household walls, floor tiles, etc.), and for many others. The environmental reward due to management the accumulated problematic solid granite scraps is, certainly, a gain.
Understanding the Adjusted Rand Index and Other Partition Comparison Indices Based on Counting Object Pairs
Authors: Warrens Matthijs J. , van der Hoef Hanneke 
Published: July 2022

AbstractIn unsupervised machine learning, agreement between partitions is commonly assessed with so-called external validity indices. Researchers tend to use and report indices that quantify agreement between two partitions for all clusters simultaneously. Commonly used examples are the Rand index and the adjusted Rand index. Since these overall measures give a general notion of what is going on, their values are usually hard to interpret. The goal of this study is to provide a thorough understanding of the adjusted Rand index as well as many other partition comparison indices based on counting object pairs. It is shown that many overall indices based on the pair-counting approach can be decomposed into indices that reflect the degree of agreement on the level of individual clusters. The decompositions (1) show that the overall indices can be interpreted as summary statistics of the agreement on the cluster level, (2) specify how these overall indices are related to the indices for individual clusters, and (3) show that the overall indices are affected by cluster size imbalance: if cluster sizes are unbalanced these overall measures will primarily reflect the degree of agreement between the partitions on the large clusters, and will provide much less information on the agreement on smaller clusters. Furthermore, the value of Rand-like indices is determined to a large extent by the number of pairs of objects that are not joined in either of the partitions.
Is new always better: comparison of the femoral neck system and the dynamic hip screw in the treatment of femoral neck fractures
Authors: Schuetze Konrad , Burkhardt Jakob , Pankratz Carlos , Eickhoff Alexander , Boehringer Alexander , Degenhart Christina , Gebhard Florian , Cintean Raffael 
Published: July 2022

Abstract
Background
Hip fractures in the elderly population are common and the number of patients is rising. For young and geriatric patients with undisplaced fractures osteosynthesis is the primary type of treatment. The dynamic hip screw (DHS) is around for many years and proved its value especially in displaced fractures. Since 2018 the femoral neck system (FNS) is available as an alternative showing promising biomechanical results. The aim of this study is to evaluate clinical results of the FNS and compare it to the DHS.

Materials and methods
Patients older than 18 years with Garden I–IV fractures that were treated with osteosynthesis in a level 1 trauma center were included in the study. Between January 2015 and March 2021, all patients treated with FNS (1-hole plate, DePuy-Synthes, Zuchwil, Switzerland) or DHS (2-hole plate, DePuy-Synthes, Zuchwil, Switzerland) for proximal femur fractures were included in the study. Closed reduction was achieved using a traction table. All operations were carried out by experienced orthopedic trauma surgeons. Primary outcome measures were rate of implant failure (cut out) and surgical complications (hematoma, infection). Secondary outcome measures were Hb-difference, length of hospital stay and mortality.

Results
Overall, 221 patients were included in the study. 113 were treated with FNS, 108 with DHS. Mean age was 69 ± 14 years. There were 17.2% Garden I, 47.5% Garden II, 26.7% Garden III and 8.6% Garden IV fractures. No difference between the groups for age, body mass index (BMI), Charlson comorbidity index (CCI), time to surgery, Pauwels and Garden classification, rate of optimal blade position or tip apex distance was found. FNS showed lower pre- to postoperative Hb-difference (1.4 ± 1.1 g/l vs. 2.1 ± 1.4 g/l; p < 0.05), shorter operating time (36.3 ± 11.6 min vs. 54.7 ± 17.4 min; p < 0.05) and hospital stay (8.8 ± 4.3 d vs. 11.2 ± 6.8 d; p < 0.05). Surgical complications (FNS 13.3% vs. DHS 18.4%, p > 0.05), rate of cut out (FNS 12.4% vs. DHS 10.2%, p > 0.05) and mortality (FNS 3.5%; DHS 0.9%; p > 0.05) showed no difference between the groups. Logistic regression showed that poor blade position was the only significant predictor for cut out and increased the risk by factor 7. Implant related infection (n = 3) and hematoma/seroma (n = 6) that needed revision was only seen in DHS group.

Conclusion
FNS proved to be as reliable as DHS in all patients with hip fractures. Not the type of implant but blade positioning is still key to prevent implant failure. Still due to minimal invasive approach implant related infections and postoperative hematomas might have been prevented using the FNS.
Treatment of snoring using a non-invasive Er:YAG laser with SMOOTH mode (NightLase): a randomized controlled trial
Authors: Picavet Valerie A. , Dellian Marc , Gehrking Eckard , Sauter Alexander , Hasselbacher Katrin 
Published: July 2022

Abstract
Objectives
The aim of this study was to assess safety and efficacy of a non-invasive 2940 nm Er:YAG treatment with SMOOTH mode in reducing snoring in adult patients and to compare its efficacy and safety to sham treatment in a randomized controlled trial setting.

Methods
40 primary snoring patients (≥ 18 year, AHI < 15e/h, BMI ≤ 30) were randomized to receive either 3 sessions NightLase or sham laser treatment. The main outcome measures were Snore Outcomes Survey (SOS), the Spouse/Bed Partner Survey (SBPS), a visual analogue snoring scale (bed partner) and a visual analogue pain scale.

Results
NightLase was well tolerated, no local anaesthesia was required (mean VAS pain score in NightLase group = 3.0 ± 1.7). No complications occurred. SOS, SBPS and VAS snoring scores improved in the NightLase group (33.7 ± 14.1 to 56.2 ± 16.1) (35.0 ± 17.1 to 61.5 ± 16.4) and (7.9 ± 2.0 to 4.7 ± 2.8) while no changing in the sham group (32.2 ± 14.5 vs 32.1 ± 13.0) (36.7 ± 12.1 vs 34.7 ± 12.7) (8.1 ± 1.7 vs 8.0 ± 1.6), respectively.

Conclusions
NightLase is a safe, minimal invasive treatment that significantly reduced snoring compared to sham treatment.
Lithium and boron diffusivity and isotopic fractionation in hydrated rhyolitic melts
Authors: Spallanzani Roberta , Koga Kenneth T. , Cichy Sarah B. , Wiedenbeck Michael , Schmidt Burkhard C. , Oelze Marcus , Wilke Max 
Published: July 2022

AbstractLithium and boron are trace components of magmas, released during exsolution of a gas phase during volcanic activity. In this study, we determine the diffusivity and isotopic fractionation of Li and B in hydrous silicate melts. Two glasses were synthesized with the same rhyolitic composition (4.2 wt% water), having different Li and B contents; these were studied in diffusion-couple experiments that were performed using an internally heated pressure vessel, operated at 300 MPa in the temperature range 700–1250 °C for durations from 0 s to 24 h. From this we determined activation energies for Li and B diffusion of 57 ± 4 kJ/mol and 152 ± 15 kJ/mol with pre-exponential factors of 1.53 × 10–7 m2/s and 3.80 × 10–8 m2/s, respectively. Lithium isotopic fractionation during diffusion gave β values between 0.15 and 0.20, whereas B showed no clear isotopic fractionation. Our Li diffusivities and isotopic fractionation results differ somewhat from earlier published values, but overall confirm that Li diffusivity increases with water content. Our results on B diffusion show that similarly to Li, B mobility increases in the presence of water. By applying the Eyring relation, we confirm that B diffusivity is limited by viscous flow in silicate melts. Our results on Li and B diffusion present a new tool for understanding degassing-related processes, offering a potential geospeedometer to measure volcanic ascent rates.
Elevated inflammatory biomarkers and poor outcomes in intracerebral hemorrhage
Authors: Bader Edward R. , Pana Tiberiu A. , Barlas Raphae S. , Metcalf Anthony K. , Potter John F. , Myint Phyo K. 
Published: July 2022

Abstract
Background
Accumulating evidence suggests that spontaneous intracerebral hemorrhage (ICH) is associated with a reactive neuroinflammatory response. However, it remains unclear if circulating inflammatory biomarkers are associated with adverse outcomes in ICH. To address this knowledge gap, we conducted a cohort study using a prospectively maintained stroke register in the United Kingdom to assess the prognostic value of admission inflammatory biomarkers in ICH.

Methods
The Norfolk and Norwich Stroke and TIA Register recorded consecutive ICH cases. The primary exposures of interest were elevation of white cell count (WCC; > 10 × 109/L), elevation of c-reactive protein (CRP; > 10 mg/L), and co-elevation of both biomarkers, at the time of admission. Modified Poisson and Cox regressions were conducted to investigate the relationship between co-elevation of WCC and CRP at admission and outcomes following ICH. Functional outcome, multiple mortality timepoints, and length of stay were assessed.

Results
In total, 1714 ICH cases were identified from the register. After adjusting for covariates, including stroke-associated pneumonia, co-elevation of WCC and CRP at admission was independently associated with significantly increased risk of poor functional outcome (RR 1.08 [95% CI 1.01–1.15]) and inpatient mortality (RR 1.21 [95% CI 1.06–1.39]); and increased 90-day (HR 1.22 [95% CI 1.03–1.45]), and 1-year mortality (HR 1.20 [95% CI 1.02–1.41]). Individual elevation of WCC or CRP was also associated with poor outcomes.

Conclusions
Elevated inflammatory biomarkers were associated with poor outcomes in ICH. This study indicates that these readily available biomarkers may be valuable for prognostication and underscore the importance of inflammation in ICH.
SALUS—a non-inferiority trial to compare self-tonometry in glaucoma patients with regular inpatient intraocular pressure controls: study design and set-up
Authors: Oldiges Kristina , Steinmann Maren , Duevel Juliane Andrea , Gruhn Sebastian , Diener Raphael , Leclaire Martin Dominik , Al-Nawaiseh Sami , Eter Nicole ,   on behalf of the SALUS study group, Greiner W. , Behm B. , Kisielinski D. , Schwarze K. , Meyer F. , Warkentin S. , Hammerschmidt R. , Luzius M. , Berlage T. , Becker M. , Charles A. , Heitkaemper R. , Weingarten B. , Boeker T. , Hermel M. , Kaskel-Paul S. , Kohlhaas M. , Alnawaiseh M. , Brücher V. C. , Czapski P. , Holtrup L. , Merté R.-L. , Storp J. J. , Treder M. , Zimmermann J. A. 
Published: July 2022

Abstract
Purpose
The SALUS study aims to improve the healthcare situation for glaucoma patients in Germany. In order to detect diurnal intraocular pressure (IOP) fluctuations, inpatient monitoring of IOP in an eye hospital for a minimum of 24 h is the current standard. SALUS assesses the benefits of a new form of outpatient care, where IOP can be measured by the patients themselves at home using a self-tonometer. This approach should promote the patient’s health competence and empowerment within the healthcare system while reducing treatment costs.

Methods
The SALUS study is a randomized controlled, open non-inferiority trial, alongside an economic analysis, determining whether outpatient monitoring of IOP with self-tonometry is at least as effective as current standard care and would reduce treatment costs. Participants (n = 1980) will be recruited by local ophthalmologists in the area of Westphalia-Lippe, Germany, and randomized to receive 7-day outpatient or 24-h inpatient monitoring. Participants in both study arms will also receive 24-h blood pressure monitoring. Furthermore, patient data from both study groups will be collected in an electronic case file (ECF), accessible to practitioners, hospitals, and the study participants. The primary endpoint is the percentage of patients with IOP peaks, defined as levels 30% above the patient-specific target pressure. Data will also be collected during initial and final examinations, and at 3, 6, and 9 months after the initial examination.

Results
The study implementation and trial management are represented below.

Conclusion
SALUS is a pioneering prospective clinical trial focused on the care of glaucoma patients in Germany. If SALUS is successful, it could improve the healthcare situation and health literacy of the patients through the introduction of various telemedical components. Furthermore, the approach would almost certainly reduce the treatment costs of glaucoma care.

Trial registration
ClinicalTrials.gov ID: NCT04698876, registration date: 11/25/2020.
DRKS-ID: DRKS00023676, registration date: 11/26/2020.
The influence of stereoscopic vision on surgical performance in minimal invasive surgery—a substudy of the IDOSP-Study (Influence of 3D- vs. 4 K-Display Systems on Surgical Performance in minimal invasive surgery)
Authors: Gietzelt Caroline , Datta Rabi , Busshoff Jana , Bruns Thomas , Wahba Roger , Hedergott Andrea 
Published: July 2022

Abstract
Purpose
This study is a secondary analysis of the IDOSP trial published in the Annals of Surgery 2020. The aim of this study was to examine the influence of stereo acuity on surgical performance in a laparoscopic training parkour with 3D- versus 4 K-2D-display technique.

Methods
The surgical performance of medical students (MS), non-board-certified surgeons (NBC), and board-certified surgeons (BC) was compared using 3D- versus 4 K-2D-display technique at a training parkour in a randomized cross-over trial. Stereo acuity was tested by TNO and Titmus Stereo tests.

Results
Eighty-nine participants were included in this sub-trial. The median stereo acuity for all participants, measured with the Titmus test, was 25 s arc, with TNO test 30 s arc. Higher quality stereo vision, measured with the Titmus test, correlated significantly with a reduced parkour time (r = 0.26, p = 0.02) and error (r = 0.21, p = 0.048) with the 3D screen. The TNO test did not correlate significantly with parkour performance. There was no statistically significant correlation between parkour time nor error and stereo acuity using the 4 K system (p > 0.457 respectively). Higher age showed a significant correlation with lower stereo acuity measured with TNO (r = 0.21, p = 0.014), but not with the Titmus test (r =  − 0.7, p = 0.39). Seven percent of the group “NBC and BC” showed reduced stereo acuity > 120 s arc with the Titmus test and 3% with the TNO test.

Conclusion
High-quality stereo vision is of utmost importance for surgical skills using a 3D-display system. This was most obvious for MS and for tasks that place particularly high demands on hand–eye coordination. The Titmus test was more precise than the TNO test to predict the benefit of a 3D monitor system. Experience and fine motor skills could partly compensate for a poorer stereo acuity.

Trial registration
This trial was registered at clinicaltrials.gov (trial number: NCT03445429, registered February 26, 2018).
On the emergence of the in–out effect across trials: two items do the trick
Authors: Topolinski Sascha , Boecker Lea , Löffler Charlotte S. , Gusmão Beatriz , Ingendahl Moritz 
Published: July 2022

AbstractIndividuals prefer letter strings whose consonantal articulation spots move from the front of the mouth to the back (e.g., BAKA, inward) over those with a reversed consonant order (e.g., KABA, outward), the so-called in–out effect. The present research explores whether individuals hold an internal standard or scheme of consonant order that triggers this effect. If this were the case, the in–out effect should already occur in one-trial between-subjects designs. If not, the in–out effect should emerge over the course of trials in within-subjects designs. In Experiments 1a–e (1b–e preregistered; total N = 2973; German, English, and Portuguese samples) employing a one-trial between-subjects design, no in–out effect was found. In Experiment 2 (N = 253), employing within-subjects designs with either 1, 5, 10, 30, or 50 trials per consonant order category (inward vs. outward), the in–out effect was absent in the first trial, but already surfaced for the first 2 trials, reached significance within the first 10 trials and a solid plateau within the first 20 trials. Of the four theoretical explanations, the present evidence favors the fluency/frequency and letter-position accounts and is at odds with the eating-related embodiment and easy-first accounts.