bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytologic features of reactive fibroplasia in cutaneous and subcutaneous lesions of dogs: A retrospective study
Authors: Masserdotti Carlo , Drigo Michele 
Published: March 2022

AbstractBackgroundDetermining reactive fibroplasia from primary neoplastic proliferation can be difficult using the cytologic features of spindle cells.ObjectivesThis study aimed to describe qualitative features of benign reactive spindle cells and provide a diagnostic tool to distinguish between fibroplasia and soft tissue sarcoma.MethodsCytologic samples from cutaneous lesions with histopathologically confirmed fibroplasia were reviewed and compared with cytologic samples from confirmed low‐grade soft tissue sarcomas. The samples were obtained from the Archive of the Laboratorio Veterinario Bresciano (Brescia; Italy).ResultsA total of 25 cytologic samples retrieved from the database fit the selection criteria. For comparison, 25 cytologic samples of histopathologically confirmed soft tissue sarcomas with secondary inflammation were obtained and reviewed from the same database. A low number of singularly distributed spindle cells with mild features of atypia and a high ratio of inflammatory to spindle cells was observed in confirmed cases of fibroplasia.ConclusionsLow cellularity, individualized spindle cells, and an increased inflammatory‐to‐spindle cell ratio were more indicative of fibroplasia than sarcoma.
International Society of Blood Transfusion survey of experiences of blood banks and transfusion services during the COVID‐19 pandemic
Authors: Al‐Riyami Arwa Z. , Burnouf Thierry , Wood Erica M. , Devine Dana V. , Oreh Adaeze , Apelseth Torunn Oveland , Goel Ruchika , Bloch Evan M. , van Den Berg Karin , Getshen Mahrukh , Louw Vernon , Ang Ai Leen , Lee Cheuk Kwong , Rahimi‐Levene Naomi , Stramer Susan L. , Vassallo Ralph , Schulze Torsten J. , Patidar Gopal Kumar , Pandey Hem Chandra , Dubey Rounak , Badawi Maha , Hindawi Salwa , Meshi Abdullah , Matsushita Tadashi , Sorrentino Enrico , Grubovic Rastvorceva Rada M. , Bazin Renée , Vermeulen Marion , Nahirniak Susan , Tsang Hamilton C. , Vrielink Hans , Triyono Teguh , Addas‐Carvalho Marcelo , Hećimović Ana , Torres Oscar W. , Mutindu Samclide M. , Bengtsson Jesper , Dominguez Diego , Sayedahmed Ahmed , Hanisa Musa Rozi , Gautam Bipul , Herczenik Eszter , So‐Osman Cynthia ,   the ISBT COVID‐19 Convalescent Plasma Working Group
Published: March 2022

AbstractBackground and ObjectivesThe coronavirus disease 2019 (COVID‐19) pandemic has impacted blood systems worldwide. Challenges included maintaining blood supplies and initiating the collection and use of COVID‐19 convalescent plasma (CCP). Sharing information on the challenges can help improve blood collection and utilization.Materials and MethodsA survey questionnaire was distributed to International Society of Blood Transfusion members in 95 countries. We recorded respondents' demographic information, impacts on the blood supply, CCP collection and use, transfusion demands and operational challenges.ResultsEighty‐two responses from 42 countries, including 24 low‐ and middle‐income countries, were analysed. Participants worked in national (26.8%) and regional (26.8%) blood establishments and hospital‐based (42.7%) institutions. CCP collection and transfusion were reported by 63% and 36.6% of respondents, respectively. Decreases in blood donations occurred in 70.6% of collecting facilities. Despite safety measures and recruitment strategies, donor fear and refusal of institutions to host blood drives were major contributing factors. Almost half of respondents working at transfusion medicine services were from large hospitals with over 10,000 red cell transfusions per year, and 76.8% of those hospitals experienced blood shortages. Practices varied in accepting donors for blood or CCP donations after a history of COVID‐19 infection, CCP transfusion, or vaccination. Operational challenges included loss of staff, increased workloads and delays in reagent supplies. Almost half of the institutions modified their disaster plans during the pandemic.ConclusionThe challenges faced by blood systems during the COVID‐19 pandemic highlight the need for guidance, harmonization, and strengthening of the preparedness and the capacity of blood systems against future infectious threats.
Comparing the emergence of Echinochloa crus‐galli populations in different locations. Part I: Variations in emergence timing and behaviour of two populations
Authors: Royo‐Esnal Aritz , Onofri Andrea , Loddo Donato , Necajeva Jevgenija , Jensen Peter K. , Economou Garifalia , Taab Alireza , Synowiec Agnieszka , Calha Isabel M. , Andersson Lars , Uludag Ahmet , Uremis Ilhan , Murdoch Alistair J. , Tørresen Kirsten S. 
Published: March 2022

AbstractEchinochloa crus‐galli (L.) P. Beauv. is one of the most important weeds. It is distributed worldwide and has adapted to diverse habitats and climatic conditions. This study aimed to compare the emergence patterns of two populations of E. crus‐galli from different environments at 11 locations across Europe and the Middle East. Seeds of the two populations were collected from maize in Italy and from spring barley in Norway and were then buried in soil in autumn 2015. In the spring of 2016, the soil was disturbed around the usual seedbed preparation date in each location and emergence was recorded. The soil was again disturbed a year later and emergence was recorded for a second season. Total emergence, the times of onset, end and to 50% emergence and the period between 25% and 75% of emergence were analysed by two‐way ANOVA and principal components analysis. The Italian population showed a higher emergence than the Norwegian population in Southern locations, while the ranking was reversed in Northern locations. In almost all locations, a tendency to emerge earlier was recorded for the Norwegian population, but the periods from 25% to 75% emergence were similar for both populations. Total emergence, and the times of onset and end of emergence seemed to be mainly under genotypic (plus maternal) control, suggesting there were different temperature thresholds for seedling emergence in each population. Conversely, the duration of emergence seemed to be mainly under environmental control. This research confirms the high variability between populations and suggests the need to continue identifying key characteristics for the development of efficient models for seedling emergence in specific climates and/or latitudes.
Stability of Hydrogen Turbopump Rotor Shaft Axially Self-Balanced
Authors: Martin Seive , Jean-Michel Nguyen Duc , Fonteyn Patrice 
Published: March 2022

Abstract
Controlling the vibration levels of turbopump rotor shafts is a key feature for the reliability of space engines. Turbopump components are exposed to high static and dynamic stress levels, and therefore are particularly sensitive to high-cycle fatigues. Among the numerous dynamic excitations that affect the turbopump, self-induced instabilities are the most critical ones because of the exponential growth rate of vibration levels. These flutter-like phenomena may account for rotor shaft instabilities of turbopumps designed with an axial balancing system (ABS). Such a system is necessary to avoid heavy static loads on bearings and is commonly used in high power turbopumps in the space industry. It consists of a fluid cavity located in the back of a centrifugal compressor. Instabilities induced by the ABS have been studied within the framework of a research and technology program using a reduced scale hydrogen turbopump demonstrator called TPtech. This paper focuses on experimental and numerical analysis of rotor instabilities induced by the ABS. A coupled dynamic model of the rotor shaft and the ABS cavity is presented. It shows instabilities of the rigid rotor axial mode, but also of an axisymmetric rotor mode. This result is consistent with the data acquired during TPtech test campaign. The instability mechanism is complex as it involves the rotor modes, the flow in the ABS cavity, and its acoustic modes. Therefore, TPtech tests performed in representative conditions are valuable. They have permitted tool validation and have provided design rules to prevent occurrence of such phenomena.
Significant Energy Deficit and Suboptimal Sleep During a Junior Academy Tennis Training Camp
Authors: Fleming James A. , Corr Liam D. , Earle James , Naughton Robert J. , Harper Liam D. 
Published: March 2022

Purpose: To assess the training load, energy expenditure, dietary intake, and sleep quality and quantity of junior tennis players during a tennis training camp. Methods: Ten junior academy tennis players (14 [1] y) completed a 6-day camp with daily morning and afternoon training. Players wore accelerometer watches to measure activity energy expenditure and sleep. Global positioning system units were worn to monitor external training load (distance covered, maximum velocity, and PlayerLoad™). Dietary intake was obtained from a food diary and supplementary food photography. Results: Players covered significantly more distance and had higher PlayerLoad™ during morning sessions than afternoon sessions (5370 [505] m vs 4726 [697] m, P < .005, d = 3.2; 725 [109] a.u. vs 588 [96] a.u., P < .005, d = 4.0). Players also ran further (5624 [897] m vs 4933 [343] m, P < .05, d = 1.0) and reached higher maximum velocities (5.17 [0.44] m·s−1 vs 4.94 [0.39] m·s−1, P < .05, d = 0.3) during simulated match play compared with drill sessions. Mean daily energy expenditure was 3959 (630) kcal. Mean energy intake was 2526 (183) kcal, resulting in mean energy deficits of 1433 (683) kcal. Players obtained an average of 6.9 (0.8) hours of sleep and recorded 28 (7) nightly awakenings. Conclusions: Junior academy tennis players failed to achieve energy balance and recorded suboptimal sleep quantity and quality throughout the training camp.
Hot atmospheric formation of carbonate accretionary lapilli at the Cretaceous-Paleogene boundary, Brazos River, Texas, from clumped isotope thermometry
Authors: Burtt David G. , Henkes Gregory A. , Yancey Thomas E. , Schrag Daniel 
Published: March 2022

Abstract
The Chicxulub impact (in the northern Yucatan Penninsula, Mexico) marks the Cretaceous-Paleogene (K-Pg) boundary and is implicated in one of the five major extinctions. Researchers have examined ejecta from the Chicxulub impact, and most recently a drill core from the crater itself, yet the processes and chemical reactions occurring in the impact vapor plume are poorly constrained. Rounded carbonate particles, identified as accretionary lapilli, have been found thousands of kilometers from the impact crater and may be a unique record of plume conditions. We present carbon (δ13C), oxygen (δ18O), and clumped (Δ47) isotope ratios of lapilli from the Brazos River, Texas (USA), as well as from foraminifera and a mudstone. Unaltered lapilli δ13C and δ18O values covary, ranging from −9.38‰ to −2.10‰ and from −7.72‰ to −5.36‰, respectively, and they are distinct from mudstones, foraminifera, and secondarily altered lapilli in the same section. Clumped isotope temperatures [T(Δ47)] from the lapilli range from 66 °C to 539 °C and average 155 ± 46 °C (1 standard deviation), with sedimentary and fossil carbonates recording clement, shallow ocean–like T(Δ47). These data are consistent with petrography and hypothesized vapor plume formation, and we argue that the δ13C and δ18O values result from target rock decarbonation. Atmospheric temperatures &gt;100 °C extending &gt;1800 km from the Chicxulub crater imply an uninhabitable zone within seconds to minutes of the impact that was 10× larger in diameter than the crater itself.
Scoping review: bladder cancer in Nigeria – what are the gaps in clinical care and research?
Authors: Iya Abdulkarim Muhammad , Beyer Katharina , Kotecha Pinky , Kibaru Joyce , Abdullahi Muzzammil , Alhassan Sani Usman , Mustapha Muhammad Inuwa , Ahmad Abdullahi , Lawal Yusuf , Rabiu Ibrahim Jalo , Aminu Aliyu , Abubakar Aisha , Saleh Abdullahi , Bryan Richard T , Van Hemelrijck Mieke , Russell Beth 
Published: March 2022

ObjectivesThere are currently no national guidelines regarding bladder cancer treatment and clinical care pathways in Nigeria. The aim of this scoping review was to identify any gaps in the knowledge of epidemiology, clinical care and translational research in order to aid the development of a defined clinical care pathway and guide future research.MethodsA scoping review was conducted by searching Medline, Ovid Gateway, The Cochrane library and Open Grey literature using predefined search terms from date of inception to June 2020. Studies were included if they discussed the epidemiology or treatment pathway of bladder cancer. All data were charted and were analysed in a descriptive manner. A consultation phase was also conducted consisting of a multidisciplinary team of clinicians and bladder cancer survivors.ResultsA total of 19 studies were deemed suitable for inclusion. The themes included the epidemiology of bladder cancer (high prevalence of schistosomiasis), research surrounding the biology of the disease and translational research including potential biomarkers. The consultation phase highlighted some possible sociocultural and infrastructural issues relating to both the diagnosis and treatment of bladder cancer, with poor knowledge of bladder cancer and its symptoms within the general population identified as a key issue.ConclusionEven though the factors surrounding the relationship between schistosomiasis and the histopathology of bladder cancer remain unclear, there is potential for screening for schistosomiasis in endemic regions of sub-Saharan Africa. Other key areas for future research include the dissemination of information to the general population surrounding bladder cancer and its symptoms to encourage prompt diagnosis.
When the game is hard, more complex weapons are needed
Authors: Mercadante Sebastiano , Adile Claudio , Ferrera Patrizia , Giuliana Fausto 
Published: March 2022

ObjectivesThe aim of this paper is to illustrate how to manage a very difficult pain condition.MethodsThis is a clinical note of a complex approach using multiple analgesic regimens to effectively afford challenging pain situations.ResultsA man underwent an opioid dose titration, followed by dose stabilisation for some months. Then he underwent two opioid substitutions, unsuccessfully. A spinal analgesia provided good analgesia for a prolonged period of time, necessitating variable interventions to counteract the evolving, challenging clinical situation.ConclusionsThe description of this case illustrates the need of a high level of experience and knowledge to elaborate complex strategies step by step every time the pain syndrome was worsening. Recommendations are unlikely in these extreme circumstances, and treatment should be based on continuous clinical counteraction to the evolving clinical conditions.
Corrigendum to “On two conjectures concerning convex curves”, by V. Sedykh and B. Shapiro
Authors: Shapiro Boris , Shapiro Michael 
Published: March 2022

As was pointed out by S. Karp, Theorem B of paper [V. Sedykh and B. Shapiro, On two conjectures concerning convex curves, Int. J. Math. 16(10) (2005) 1157–1173] is wrong. Its claim is based on an erroneous example obtained by multiplication of three concrete totally positive [Formula: see text] upper-triangular matrices, but the order of multiplication of matrices used to produce this example was not the correct one. Below we present a right statement which claims the opposite to that of Theorem B. Its proof can be essentially found in a recent paper [N. Arkani-Hamed, T. Lam and M. Spradlin, Non-perturbative geometries for planar [Formula: see text] SYM amplitudes, J. High Energy Phys. 2021 (2021) 65].
On effects of the nonlinear signal production to the boundedness and finite-time blow-up in a flux-limited chemotaxis model
Authors: Tu Xinyu , Mu Chunlai , Zheng Pan 
Published: March 2022

We study herein the initial–boundary value problem for the flux-limited chemotaxis model with nonlinear signal production [Formula: see text] subject to no-flux boundary conditions in a ball [Formula: see text], where [Formula: see text], [Formula: see text]. For radially symmetric and positive initial data [Formula: see text], it is proved that the corresponding solution is globally bounded when [Formula: see text]. This result not only fills up a gap left in [M. Mizukami, T. Ono and T. Yokota, Extensibility criterion ruling out gradient blowup in a quasilinear degenerate chemotaxis system, J. Differ. Equ. 267(2019) 5115–5164; Y. Chiyoda, M. Mizukami and T. Yokota, Finite-time blow-up in a quasilinear degenerate chemotaxis system with flux limitation, Acta. Appl. Math. 167 (2020) 231–259] when [Formula: see text], but also extend the boundedness result from the special case [Formula: see text] to the general case [Formula: see text]. Moreover, under the condition [Formula: see text] it is shown that if [Formula: see text] is sufficiently large, then there exists initial data [Formula: see text] such that the corresponding solution blows up at finite time [Formula: see text] in the sense that [Formula: see text] This blow-up result generalizes the works for the linear signal production case in (N. Bellomo and M. Winkler, Finite-time blow-up in a degenerate chemotaxis system with flux limitation, Trans. Am. Math. Soc. Ser. B 4 (2017) 31–67; Y. Chiyoda, M. Mizukami and T. Yokota, Finite-time blow-up in a quasilinear degenerate chemotaxis system with flux limitation, Acta. Appl. Math. 167 (2020) 231–259) to the nonlinear case [Formula: see text].
LookOut! Interactive Camera Gimbal Controller for Filming Long Takes
Authors: Sayed Mohamed , Cinca Robert , Costanza Enrico , Brostow Gabriel 
Published: March 2022

The job of a camera operator is challenging, and potentially dangerous, when filming long moving camera shots. Broadly, the operator must keep the actors in frame while safely navigating around obstacles and while fulfilling an artistic vision. We propose a unified hardware and software system that distributes some of the camera operator’s burden, freeing the operator up to focus on safety and aesthetics during a take. Our real-time system provides solo operators with end-to-end control so that they can balance on-set responsiveness to action against planned storyboards and framing while looking where they are going. By default, we film without a field monitor.
Our LookOut system is built around a lightweight commodity camera gimbal mechanism, with heavy modifications to the controller, which would normally just provide active stabilization. Our control algorithm reacts to speech commands, video, and a premade script. Specifically, our automatic monitoring of the live video feed saves the operator from distractions. In preproduction, an artist uses our graphical user interface (GUI) to design a sequence of high-level camera “behaviors.” Those can be specific, based on a storyboard, or looser objectives, such as “frame both actors.” Then, during filming, a machine-readable script, exported from the GUI, ties together with the sensor readings to drive the gimbal. To validate our algorithm, we compared tracking strategies, interfaces, and hardware protocols and collected impressions from (a) filmmakers who used all aspects of our system and (b) filmmakers who watched footage filmed using LookOut.
A Large-Scale Comparison of Tetrahedral and Hexahedral Elements for Solving Elliptic PDEs with the Finite Element Method
Authors: Schneider Teseo , Hu Yixin , Gao Xifeng , Dumas Jérémie , Zorin Denis , Panozzo Daniele 
Published: March 2022

The
Finite Element Method (FEM)
is widely used to solve discrete
Partial Differential Equations (PDEs)
in engineering and graphics applications. The popularity of FEM led to the development of a large family of variants, most of which require a tetrahedral or hexahedral mesh to construct the basis. While the theoretical properties of FEM basis (such as convergence rate, stability, etc.) are well understood under specific assumptions on the mesh quality, their practical performance, influenced
both
by the choice of the basis construction and quality of mesh generation, have not been systematically documented for large collections of automatically meshed 3D geometries.

We introduce a set of benchmark problems involving most commonly solved elliptic PDEs, starting from simple cases with an analytical solution, moving to commonly used test problem setups, and using manufactured solutions for thousands of real-world, automatically meshed geometries. For all these cases, we use state-of-the-art meshing tools to create both tetrahedral and hexahedral meshes, and compare the performance of different element types for common elliptic PDEs.
The goal of this benchmark is to enable comparison of complete FEM pipelines, from mesh generation to algebraic solver, and exploration of relative impact of different factors on the overall system performance.
As a specific application of our geometry and benchmark dataset, we explore the question of relative advantages of unstructured (triangular/ tetrahedral) and structured (quadrilateral/hexahedral) discretizations. We observe that for Lagrange-type elements, while linear tetrahedral elements perform poorly, quadratic tetrahedral elements perform equally well or outperform hexahedral elements for our set of problems and currently available mesh generation algorithms. This observation suggests that for common problems in structural analysis, thermal analysis, and low Reynolds number flows, high-quality results can be obtained with unstructured tetrahedral meshes, which can be created robustly and automatically.
We release the description of the benchmark problems, meshes, and reference implementation of our testing infrastructure to enable statistically significant comparisons between different FE methods, which we hope will be helpful in the development of new meshing and FEA techniques.
Abstract ES11-2: Macro and Micro: Macrophage and microbiome diversity in the breast cancer microenvironment
Authors: Guerriero JL 
Published: March 2022

Abstract
The breast tumor microenvironment (TME), devoid of nutrients and oxygen, recruits tumor associated macrophages (TAMs) that promote angiogenesis, metastasis and tumor growth. Removal or conversion of TAMs to an anti-tumor phenotype enhances chemo- and immuno-therapy in pre-clinical models and establishes TAMs as targets for anti-cancer therapy. Translation to the clinic has been slow, likely because current strategies broadly target macrophages. Several subsets of TAMs have been identified, yet little is known about their subset diversity in breast cancer and response to therapy. The failure to characterize TAM subsets has likely hindered progress in therapeutic targeting. This educational talk will provide a broad overview of the diversity of TAMs as well as the microbiome and how they are potentially intertwined within the complex breast TME. The talk will incorporate the state of the field to include elucidating the complexity of TAMs in breast cancer including their ontogeny, tissue specificity, phenotype, subset diversity and spatial relationship within the breast tumor. In addition, how the tumor microbiome may influence myeloid function and phenotype will be explored.
Citation Format: JL Guerriero. Macro and Micro: Macrophage and microbiome diversity in the breast cancer microenvironment [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr ES11-2.
Abstract ES12-1: Monitoring of advanced breast cancer with liquid biopsies
Authors: Bidard F 
Published: March 2022

Abstract
This talk will focus on the currently available data supporting the validity and utility of circulating tumor DNA for the monitoring and management of metastatic breast cancers, and provide a perspective on future developments.
Citation Format: F Bidard. Monitoring of advanced breast cancer with liquid biopsies [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr ES12-1.