bluuebunny/crossref_metadata_2025_split huggingface dataset:
External cardioversion of atrial fibrillation and flutter in patients with cardiac implantable electrical devices
Authors: Elgaard Anders Fyhn , Dinesen Pia Thisted , Riahi Sam , Hansen John , Lundbye‐Christensen Søren , Thøgersen Anna Margrethe , Larsen Jacob Moesgaard 
Published: November 2022

AbstractBackgroundAtrial fibrillation and flutter are often treated with external electrical cardioversion (ECV) in patients with potentially electrically sensitive cardiovascular implantable electronic devices (CIED). Long‐term follow‐up data on contemporary CIED undergoing ECV is sparse. The aim is to investigate shock‐related complications and impact on CIEDs.MethodsAll ECV procedures from 2010 to 2020 in patients with CIED performed at a tertiary university hospital were identified in the Danish National Patient Registry. Changes in device measurements after ECV were retrospectively studied and procedure‐related complications were identified by review of medical records.ResultsWe analyzed 763 ECV procedures in 372 patients, median device implant time 1.9 years. The mean age of patients was 69.9 ± 9.9 years of which 73.4% were men. We identified two cases of device programming changes and four cases of premature battery depletion (≤3 years after device implant). Minor changes in device measurements were found for impedances, sensing, and pacing thresholds. No patients died due to ECV‐related device dysfunctions within the first 12 months after cardioversions.ConclusionExternal cardioversion in patients with contemporary pacemakers and implantable cardioverter‐defibrillators seems safe in the majority of patients. Clinically important changes in device function following cardioversion were rarely observed but may be critical for device function. In an observational study, causality between cardioversion and device dysfunction cannot be established. For patient safety, we suggest that routine device interrogation after cardioversion still should be part of standard care.
The role of cannabis in treatment‐resistant fibromyalgia women
Authors: Hershkovich Oded , Hayun Yemima , Oscar Nataly , Shtein Arnold , Lotan Raphael 
Published: November 2022

AbstractBackgroundFibromyalgia is a complex pain‐focused syndrome. Previous studies showed that Cannabis is efficacious in promoting sleep, deepening and lengthening the sleep cycle, and good pain relief (compared with the SSRIs and SNRIs).PurposeThis study aimed to use the World Health Organization Quality of Life Bref questionnaire (WhoQoL‐bref) to characterize the impact of Cannabis Treatment initiation on the quality of life in women suffering from treatment‐resistant fibromyalgia.MethodsA prospective cohort study involving 30 women aged 18–70 years old diagnosed with fibromyalgia, exhausted pharmacological fibromyalgia treatment, and started Cannabis treatment. Pregnant women were excluded.WhoQoL‐bref was filled before Cannabis treatment initiation and 1 month following treatment.ResultsWomen's average age was 46 years (±5), with a poor general quality of life (1.47 ± 0.63), poor general health (1.47 ± 0.78), pain and discomfort, and dependence on medication (3.77 ± 1.3 and 3.07 ± 1.74, respectively) prior to Cannabis intervention. Cannabis treatment for 30 days showed a marked improvement in general quality of life (1.97 scores, p < 0.01), general health (1.83, p < 0.01), physical health (1.5, p < 0.01), and psychological domain (1.3, p < 0.01). Financial resources and home environment were not influenced by cannabis treatment (p = 0.07, p = 0.31, respectively).ConclusionResults suggest a potentially significant role of Cannabis in treatment‐resistant Fibromyalgia women. Early Cannabis treatment may result in a beneficial short‐term effect on the quality of life through its influence on pain, sleep, and physical and psychological domains. Further studies are still indicated to understand this potential and its long‐term beneficial impact.
Dorsal root ganglion stimulation for the treatment of joint pain with predominantly nociceptive characteristics: A case series
Authors: Chapman Kenneth B. , Tupper Connor , Vissers Kris C. , van Helmond Noud , Yousef Tariq 
Published: November 2022

AbstractIntroductionDorsal root ganglion stimulation (DRG‐S) has recently emerged as a novel therapy in neuromodulation that demonstrated a higher rate of success than spinal cord stimulation (SCS) in a prospective, head‐to‐head randomized comparative trial to treat complex regional pain syndrome (CRPS) and causalgia. In contrast to SCS, DRG‐S also shows promise in treating conditions that are not purely neuropathic such as axial low back pain, which has a prominent nociplastic pain component. It is not known to what extent the effectiveness of DRG‐S for such indications is due to effective treatment of the neuropathic pain component versus the effects of DRG‐S on mechanical pain. Although rarely studied, reporting outcomes of DRG‐S to treat predominantly mechanical/nociceptive pain may help point toward expanding the utility of this therapy. Here, we present five cases of refractory mechanical pain treated with DRG‐S.MethodsA retrospective analysis of all patients who underwent a successful DRG‐S trial and implant between September 2017 and September 2021 at our institute was performed. Patients who had intractable joint pain without strong evidence of neuropathic pain were included in this case series. The Budapest criteria for CRPS, the Douleur Neuropathique 4 Questions (DN4) survey, or a definable nerve injury were used to determine the presence of neuropathic pain. Baseline assessments for pain (Numeric Rating Scale [NRS]), function (Oswestry Disability Index [ODI]), quality of life (EuroQol‐5 Dimension [EQ‐5D]), and other applicable joint surveys were extracted from pre‐trial baseline and follow‐up appointments.ResultsFive patients were identified and included. Patient diagnoses consisted of refractory joint pain of the hip, knee, or ankle. Mean NRS pain scores improved by 74% from 9.2 at baseline to 2.4 at the last follow‐up (mean = 28 months post‐implant). From baseline to the last follow‐up, mean ODI scores improved by 65% from 66 to 23 and EQ‐5D scores more than doubled from an average of 0.371 to 0.797.ConclusionThis clinical report illustrates the potential utility DRG‐S has in treating pain that clinically presents as predominantly refractory mechanical joint pain without a significant neuropathic component. The physiological reasons for our observations may be that DRG‐S is able to directly influence the conduction of nociceptive signaling at the DRG and within the spinal cord. Further investigations are warranted to determine if DRG‐S is a potential treatment option for chronic mechanical pain.
The shaping of moral injury among UK military veterans of the wars in Afghanistan and Iraq
Authors: Hollis Jake , Hanna Paul , Perman Gemma 
Published: November 2022

AbstractObjectiveResearch on ‘moral injury’—the psychological wound experienced by military personnel and other ‘functionaries’ whose moral values are violated—has proliferated in recent years. Many psychological researchers, including those in the UK, have subscribed to an increasingly individualised operationalisation of moral injury, with medicalised criteria that closely mirrors PTSD. This trend carries assumptions that have not been comprehensively verified by empirical research. This study aims to explore UK military veterans' experiences of, and challenges to, their moral values in relation to their deployment experiences, without prematurely foreclosing exploration of wider systemic influences.MethodTwelve UK military veterans who served in Afghanistan and/or Iraq were interviewed, and the data were analysed thematically and reflexively.ResultsThree inter‐related themes were generated: (1) ‘you've been undermined’, (2) ‘how am I involved in this?’ and (3) ‘civilianised’.ConclusionsThe analysis suggests that several assumptions privileged in moral injury research may be empirically contradicted, at least in relation to the experiences of UK military veterans. These assumptions include that moral injury is exclusively driven by individual, episodic acts of commission and omission, invariably leads to guilt and necessarily bifurcates into variants of either perpetration or betrayal. Instead, participants understood the moral violations they experienced as socially contingent. Rather than ‘treating’ moral injury as a disorder of thinking and feeling located within an individual, the socially contextualised understanding of moral injury indicated by this study's findings may prompt the development of psychological and social interventions that understand moral injury as the fallout of what occurs between people and within systems.
Molecular assessment of Ulva (Ulvales, Chlorophyta) diversity in Vietnam including the new species U. vietnamensis
Authors: Tran Lan‐Anh T. , Leliaert Frederik , Vieira Christophe , Tran Tien V. , Nguyen Tu V. , Dam Tien D. , De Clerck Olivier 
Published: November 2022

SUMMARYSpecies diversity of Ulva in Vietnam was investigated using three commonly used genetic markers, the nuclear encoded rDNA ITS region and the plastid encoded rbcL and tufA genes. Single locus species delimitation methods, complemented with morphological and ecological information resulted in the delimitation of 19 species. This diversity is largely incongruent with the traditional understanding of Ulva diversity in Vietnam. Only four species identified in this study, U. lactuca, U. reticulata, U. spinulosa, and U. flexuosa, have been previously reported, and seven species, U. ohnoi, U. tepida, U. chaugulii, U. kraftiorum, U. meridionalis, U. limnetica, and U. aragoënsis, are recorded for the first time from Vietnam. Seven genetic clusters could not be associated with species names with certainty. A new species, U. vietnamensis, is described from marine to brackish coastal areas from southern Vietnam based on its morphological and molecular distinctiveness from the currently known Ulva species. A comparison with recent molecular‐based studies of Ulva diversity showed that species composition in Vietnam is similar to that of adjacent countries, including Japan, China, as well as Australia. Our study emphasizes the importance of molecular data in the assessment of Ulva diversity, and indicates that a lot of diversity may still remain to be discovered, especially in tropical regions.
Falstaff on Tour: County, Town and Country in the Late Elizabethan Theatre
Authors: Rhodes Neil 
Published: November 2022

AbstractWhy does Falstaff travel to York via Gloucestershire in Henry the Fourth, part two? And why does Shakespeare interrupt his second tetralogy of history plays to take his most famous comic character to Windsor in the Merry Wives? This article uses Falstaff's tour of England in these two plays to explore an idea of the country founded upon local identities rather than on the overarching appeal of nationhood. Drawing upon chorography and social history, it focusses on the association of people and place and offers a view of England from the ground up rather than through the more imposing structures of political narrative and symbolic form.
Moral Responsibility is Not Proportionate to Causal Responsibility
Authors: Demirtas Huzeyfe 
Published: November 2022

AbstractIt seems intuitive to think that if you contribute more to an outcome, you should be more morally responsible for it. Some philosophers think this is correct. They accept the thesis thatceteris paribusone's degree of moral responsibility for an outcome is proportionate to one's degree of causal contribution to that outcome. Yet, what the degree of causal contribution amounts to remains unclear in the literature. Hence, the underlying idea in this thesis remains equally unclear. In this article, I will consider various plausible criteria for measuring degrees of causal contribution. After each of these criteria, I will show that this thesis entails implausible results. I will also show that there are other plausible theoretical options that can account for the kind of cases that motivate this thesis. I will conclude that we should reject this thesis.
The heavy tetra-quark states after the discovery of tetra-charm states.
Authors: Becchi C. 
Published: November 2022

AbstractThis paper is devoted to the study of exclusive charm and bottom bound states which are suitable, at least partially, for a non-relativistic description. Starting from a simple choice of quarkonia and tetra-quark wave functions we study their production cross sections, total widths and more interesting decay properties. In particular, we compute the production cross sections of the ground state scalar quarkonia getting results compatible with the values appearing in the literature. We also compute the production cross sections of the lower energy states of the charm and bottom tetra-quarks, their decay widths and the decay rates in two $$\mu \bar{\mu }$$

μ

μ

¯

pairs and in the $$q{\bar{q}}\mu \bar{\mu }$$

q

q

¯

μ

μ

¯

channel. Our results on the tetra-charm are consistent with the data published by the LHCb Collaboration and those on the tetra-bottom show a reasonable agreement with the indications published by the CMS Collaboration. Our cross section analyses are based on interpolations based on the gluon–gluon luminosity grids published by the NNPDF and CTEQ Collaborations. The hard amplitude calculations are based on QCD in the tree approximation. We think that a careful improvement of our method and a refinement of the experimental data after the foreseen luminosity increase at the LHC will make possible valuable tests of QCD at the intermediate energies.
Impact of Patient-Reported Outcome Measurement in Heart Failure Clinic on Clinician Health Status Assessment and Patient Experience: A Substudy of the PRO-HF Trial
Authors: Sandhu Alexander T. , Zheng Jimmy , Kalwani Neil M. , Gupta Anshal , Calma Jamie , Skye Megan , Lan Roy , Yu Brian , Spertus John A. , Heidenreich Paul A. 
Published: November 2022

Background:
Clinicians typically estimate heart failure health status using the New York Heart Association Class, which is often discordant with patient-reported health status. It is unknown whether collecting patient-reported health status improves the accuracy of clinician assessments.

Methods:
The PRO-HF trial (Patient-Reported Outcomes in Heart Failure Clinic) is a randomized, nonblinded trial evaluating routine Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) collection in heart failure clinic. Patients with a scheduled visit to Stanford heart failure clinic between August 30, 2021 and June 30, 2022 were enrolled and randomized to KCCQ-12 assessment or usual care. In this prespecified substudy, we evaluated whether access to the KCCQ-12 improved the accuracy of clinicians’ New York Heart Association assessment or patients’ perspectives on their clinician interaction. We surveyed clinicians regarding their patients’ New York Heart Association Class, quality of life, and symptom frequency. Clinician responses were compared with patients’ KCCQ-12 responses. We surveyed patients regarding their clinician interactions.

Results:

Of the 1248 enrolled patients, 1051 (84.2%) attended a visit during the substudy. KCCQ-12 results were given to the clinicians treating the 528 patients in the KCCQ-12 arm; the 523 patients in the usual care arm completed the KCCQ-12 without the results being shared. The correlation between New York Heart Association Class and KCCQ-12 Overall Summary Score was stronger when clinicians had access to the KCCQ-12 (r=−0.73 versus r=−0.61,
P
<0.001). More patients in the KCCQ-12 arm strongly agreed that their clinician understood their symptoms (95.2% versus 89.7% of respondents [odds ratio‚ 2.27; 95% CI‚ 1.32–3.87]). However, patients in both arms reported similar quality of clinician communication and therapeutic alliance.

Conclusions:
Collecting the KCCQ-12 in heart failure clinic improved clinicians’ accuracy of health status assessment; correspondingly, patients believed their clinicians better understood their symptoms.

Registration:

URL:
https://www.clinicaltrials
.gov; Unique identifier: NCT04164004.
Potential Role of Surgical Resection for Gallbladder Cancer in Elderly Patients
Authors: Ueda Yasuhiro , Yanagimoto Hiroaki , Ajiki Tetsuo , Tsugawa Daisuke , Asakura Riki , Urade Takeshi , Nanno Yoshihide , Fukushima Kenji , Gon Hidetoshi , Komatsu Shohei , Kuramitsu Kaori , Goto Tadahiro , Asari Sadaki , Toyama Hirochika , Kido Masahiro , Fukumoto Takumi 
Published: November 2022

Introduction With the aging of the population in Japan, gallbladder cancer (GBC) in the elderly is increasing. However, the available clinical data are limited, and the optimal treatment is still controversial. The aim of this study was to evaluate the benefit of surgical resection in GBC patients ≥75 years of age. Methods A retrospective single center analysis of patients who had undergone surgical resection for GBC between 2000 and 2019 was carried out. Patients aged ≥75 years (elderly group, n = 24) or <75 years (younger group, n = 50) were compared. Results Both younger and elderly patients exhibited similar clinicopathological characteristics, but comorbidity in the latter was significantly greater, as was the frequency of less invasive surgery. Nonetheless, the incidence of postoperative complications was similar in elderly and younger patients. The proportion of patients receiving adjuvant chemotherapy was lower in the elderly. Overall survival of elderly and younger patients was not significantly different (65.0 vs 62.4% at 5 years, P = .600). In multivariate analysis, residual tumor status but not age was an independent prognostic factor. Discussion This study demonstrated that appropriate surgical treatment of elderly GBC patients was safe and effective, despite their having more comorbidities and lower rates of adjuvant chemotherapy than younger patients.
Cognitive remediation therapy: is it a feasible and acceptable psychological treatment for borderline personality disorder?
Authors: Dinu Bianca , Dark Frances 
Published: November 2022

Objective Cognitive remediation (CR) is increasingly being used to address the cognitive impairment that can occur in people diagnosed with borderline personality disorder (BPD). This study aimed to understand attitudes towards CR in this service user group from the perspective of the person with the diagnosis and clinicians involved in their care. Method Anonymous online surveys were made available to people with a diagnosis of BPD in a public mental health service and clinicians of the same service. Results Thirty-three percent of service users with a diagnosis of BPD responded to the survey. Most respondents (93%) expressed a desire to improve their cognition and were interested in cognitive remediation therapy (83%). Most staff (88%) recognised cognitive impairment can occur in people with a diagnosis of BPD and the same proportion believed cognitive skills impact on patient’s emotional and mental health. Seventy percent of respondents believed CR would be useful for this service user group. Conclusions It is important that interventions to address the cognitive impairment associated with BPD are made available and that they are well integrated into the person’s overall care plan.
Glycaemic variability and risk of adverse cardiovascular events in acute coronary syndrome
Authors: Zhang Lei , Li Feng , Liu Huan-Huan , Zhang Zhi-Yuan , Yang Fan , Qian Ling-Ling , Wang Ru-Xing 
Published: November 2022

Objective The relationship between different glycaemic variability (GV) indexes and adverse cardiovascular outcomes is not well understood. This study aims to determine whether GV is related to the occurrence of adverse cardiovascular events in patients with acute coronary syndrome (ACS). Methods PubMed, EMBASE, and Web of Science were comprehensively searched from the establishment of databases to 29 June 2022. The relationship between two important GV indexes, including the mean amplitude of glycemic excursion (MAGE) and standard deviation (SD), and the adverse cardiovascular events in ACS patients were evaluated, respectively. Results A total of 11 studies with 3709 ACS patients were included. Pooled results showed that patients with higher GV had significantly increased risk of adverse cardiovascular events, including MAGE (relative risk [RR] = 1.76, 95% CI: 1.40 to 2.22, p < 0.001, I2 = 25%) and SD (RR = 2.14, 95% CI: 1.73 to 2.66, p < 0.001, I2 = 0%). Conclusions Increased GV is related to the poor prognosis in patients with ACS. Additionally, more well-designed studies comparing different indicators of GV with adverse cardiovascular events in ACS patients are still warranted.
Infection Rate in Type I Open Distal Radius Fractures Surgically Treated >24 Hours Post-Injury: A Comparison Study
Authors: Colello Michael J. , Long Edward , Zimmerman Parker , Tanner Stephanie L. , Faucher Gregory 
Published: November 2022

Purpose: To determine how time to surgical debridement and fixation affects infection and complication rate in type I open distal radius fractures by comparing patients treated within 24 hours with those treated >24 hours post-injury. Methods: A retrospective review identified 62 patients who sustained a type I open distal radius fracture that was treated surgically. Patients were stratified into groups based on time to surgical intervention. An additional analysis was performed on patients with an isolated type I open distal radius fracture treated as an inpatient or outpatient. The primary outcome measure was infection rate. Secondary outcome measures were complications, reoperations, and readmissions. Results: Thirty-eight patients underwent surgery ≤24 hours post-injury at an average of 14 hours. Twenty-four patients underwent surgery >24 hours post-injury at an average of 72 hours. There were a total of 9 complications in 8 patients (14.5%). The overall infection rate was 1.6%, with only 1 deep infection occurring in the group treated ≤24 hours post-injury. There were 7 reoperations (11.3%) and 1 readmission (1.6%). No differences were found between groups in any outcome measure. In the 27 patients with an isolated fracture, there were no differences in any outcome measure when treated as an inpatient or outpatient. Conclusions: We suggest that type I open distal radius fractures could be safely treated surgically >24 hours post-injury without increased risk of infection.