bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exclusive Breastfeeding and Factors Influencing Its Abandonment During the 1st Month Postpartum Among Women From Semi-rural Communities in Southeast Mexico
Authors: Vázquez-Osorio Inocente Manuel , Vega-Sánchez Rodrigo , Maas-Mendoza Eric , Heller Rouassant Solange , Flores-Quijano María Eugenia 
Published: February 2022

IntroductionIn this study we describe breastfeeding practices among women from semi-rural communities in southeast Mexico, and explore which factors, modifiable or not, are associated with such practices.Materials and MethodsThis was a formative cross-sectional study that included 143 mothers with infants 4–6 months old, from semi-rural communities in Tabasco, Mexico. We collected data on two categories of factors: (1) women's sociodemographic characteristics, and (2) maternal / infant factors. We first analyzed the frequency of various breastfeeding practices. Then, we classified participants into the up to 1 month of exclusive breastfeeding group ( ≤ 1 m-EBF) and the beyond 1 month EBF group (&gt;1 m-EBF), if they practiced EBF for less or more than 1 month, respectively. We compared the two categories of factors between groups and then, using logistic regression models, explored which factors were associated with practicing &gt;1 m-EBF.ResultsBy the end of the 1st month postpartum, 51.7% of participants had abandoned EBF, introduced milk formula (35%), other food (9.1%), non-nutritive liquids (7.7%), or had stopped breastfeeding completely. In the next months, EBF practice fell sharply and mixed feeding grew importantly.Logistic regression models showed that women were more likely to be in the &gt;1 m-EBF group if they lived with the baby's father, had complications during pregnancy, delivered vaginally and attended a health center at least three times postpartum. To the contrary, women were less likely to be practice &gt;1 m-EBF if they gave infants other liquids during their hospital stay; experienced pain or discomfort in breasts/nipples, or used a pacifier after hospitalization; had larger bodies (i.e., higher BMI); and believed that you should give the infant powdered milk or some other food when the baby is not full.ConclusionMany factors associated with abandoning EBF, particularly in the early postpartum period, are modifiable and can be altered through timely interventions that include giving correct information and ensuring its comprehension; assertive personal counseling and accompaniment must be provided to mothers; and reinforcement during the early postpartum at health facilities and other settings.
Magnetic Resonance Imaging Quantification of the Liver Iron Burden and Volume Changes Following Treatment With Thalidomide in Patients With Transfusion-Dependent ß-Thalassemia
Authors: Che Jinlian , Luo Tianying , Huang Lan , Lu Qiyang , Yan Da , Meng Yinying , Xie Jinlan , Chen Weihua , Chen Jiangming , Long Liling 
Published: February 2022

Clinical trials have indicated that thalidomide could be used to treat thalassemia, but evidence of changes in liver iron burden and liver volume during thalidomide treatment is lacking. This study aimed to evaluate the liver iron burden and volume changes following thalidomide treatment in patients with transfusion-dependent ß-thalassemia. A total of 66 participants with transfusion-dependent ß-thalassemia were included in this prospective cohort study between January 2017 and December 2020. Patients were treated with thalidomide (150–200 mg/day) plus conventional therapy. Liver volume, liver R2*, and hepatic muscle signal ratio (SIR)_T1 and SIR_T2 were measured with magnetic resonance imaging (MRI), and serum ferritin, hemoglobin, erythrocyte and platelet counts, and liver function were measured at baseline and at the 3rd and 12th months. Adverse events were also noted. Patients showed progressive increase in hemoglobin, erythrocyte, platelet count, SIR_T1, and SIR_T2 during the 12-months follow up. Serum ferritin, R2*, and liver volume progressively decreased during the follow up. The R2* value had a significantly positive correlation with serum ferritin, and SIR_T1 and SIR_T2 had a significantly negative correlation with serum ferritin. No serious adverse events were observed. This study showed that thalidomide could potentially be used to successfully treat patients with transfusion-dependent ß-thalassemia; the liver iron burden and liver volume could be relieved during treatment, and the MRI-measured R2*, SIR_T1, and SIR_T2 may be used to noninvasively monitor liver iron concentration.
Sex Differences in Kappa Opioid Receptor Agonist Mediated Attenuation of Chemotherapy-Induced Neuropathic Pain in Mice
Authors: Paton Kelly F. , Luo Dan , La Flamme Anne C. , Prisinzano Thomas E. , Kivell Bronwyn M. 
Published: February 2022

Chemotherapy-induced neuropathic pain is a common side effect for cancer patients which has limited effective treatment options. Kappa opioid receptor (KOR) agonists are a promising alternative to currently available opioid drugs due to their low abuse potential. In the current study, we have investigated the effects of Salvinorin A (SalA) analogues, 16-Ethynyl SalA, 16-Bromo SalA and ethyoxymethyl ether (EOM) SalB, and in a preclinical model of paclitaxel-induced neuropathic pain in male and female C57BL/6J mice. Using an acute dose-response procedure, we showed that compared to morphine, 16-Ethynyl SalA was more potent at reducing mechanical allodynia; and SalA, 16-Ethynyl SalA, and EOM SalB were more potent at reducing cold allodynia. In the mechanical allodynia testing, U50,488 was more potent in males and SalA was more potent in females. There were no sex differences in the acute cold allodynia testing. In the chronic administration model, treatment with U50,488 (10 mg/kg) reduced the mechanical and cold allodynia responses to healthy levels over 23 days of treatment. Overall, we have shown that KOR agonists are effective in a model of chemotherapy-induced neuropathic pain, indicating that KOR agonists could be further developed to treat this debilitating condition.
Recent Advance of Nanomaterial-Mediated Tumor Therapies in the Past Five Years
Authors: Hao Xinyan , Wu Junyong , Xiang DaXiong , Yang Yongyu 
Published: February 2022

Cancer has posed a major threat to human life and health with a rapidly increasing number of patients. The complexity and refractory of tumors have brought great challenges to tumor treatment. In recent years, nanomaterials and nanotechnology have attracted more attention and greatly improved the efficiency of tumor therapies and significantly prolonged the survival period, whether for traditional tumor treatment methods such as radiotherapy, or emerging methods, such as phototherapy and immunotherapy, sonodynamic therapy, chemodynamic therapy and RNA interference therapeutics. Various monotherapies have obtained positive results, while combination therapies are further proposed to prevent incomplete eradication and recurrence of tumors, strengthen tumor killing efficacy with minimal side effects. In view of the complementary promotion effects between different therapies, it is vital to utilize nanomaterials as the link between monotherapies to achieve synergistic performance. Further development of nanomaterials with efficient tumor-killing effect and better biosafety is more in line with the needs of clinical treatment. In a word, the development of nanomaterials provides a promising way for tumor treatment, and here we will review the emerging nanomaterials towards radiotherapy, phototherapy and immunotherapy, and summarized the developed nanocarriers applied for the tumor combination therapies in the past 5 years, besides, the advances of some other novel therapies such as sonodynamic therapy, chemodynamic therapy, and RNA interference therapeutics have also been mentioned.
Stress and Sleep Disorders in Polish Nursing Students During the SARS-CoV-2 Pandemic—Cross Sectional Study
Authors: Bodys-Cupak Iwona , Czubek Kamila , Grochowska Aneta 
Published: February 2022

IntroductionThe world pandemic of the virus SARS-CoV-2 , which causes COVID-19 infection was announced by the World Health Organization (WHO) on March 11, 2020. Due to the restrictions that were introduced in order to minimize the spread of the virus, people more often suffer from stress, depression, anxiety, and sleep disorders. The aim of this study was evaluation of the stress levels and sleep disorders among nursing students during the pandemic SARS-CoV-2 .Materials and Study MethodsThis is a cross-sectional study conducted among 397 nursing students on March 2020. The research tools used were original questionnaires, Perceived Stress Scale (PSS10), and the Athenian Insomnia Scale (AIS), as well as Coping with Stress Inventory (MiniCOPE).ResultsRespondents felt a high level of stress, which occurred in 68.8% of interviewees regarding whether there was a danger of contracting COVID-19. Respondents experienced 84% stress levels when a family member suffered from COVID-19. Sleep disorders were determined mainly by the fear of infection and contact with someone who might be infected with the virus. Nursing students who felt a high level of stress often suffered from sleep disorders (70.2%) more frequently than students who felt a low or average stress level (30.4%). The respondents decided to cope with stress by denial, taking psychoactive substances, ceasing action, or blaming themselves. The greater the intensity of stress experienced by students, the more often they undertook avoidance behaviors or showed helplessness.ConclusionDuring the pandemic, students experienced severe stress, which resulted in sleep disorders and avoidance behaviors.
Dialogue Based Early Detection—Development of a Novel Approach for Detection of Mental Health Problems Among Children in Daycare Centers
Authors: Bjelland Ingvar , Posserud Maj-Britt , Wergeland Gro Janne 
Published: February 2022

BackgroundAmong 1–7 years old children the worldwide prevalence of mental disorders is ~20%. Without treatment, the prognosis of such disorders in children is poor. Early intervention is estimated to result in a positive return. However, traditional screening to detect children at need is particularly challenging due to the concerns by false positives. The aim of the current study was to develop a more acceptable though effective method using the existing annual evaluation meetings between parents and teachers in a more systematic and goal directed way. The method should build on the teacher's and parents' complementary knowledge and perception of the child, and fit into the everyday routines in daycare centers.MethodDuring a period of 6 years, a developmental process aiming for a novel screening method was carried out in cooperation with eight Norwegian daycare centers. After conception of the idea, the framework of the Dialogue Based Early Detection including the first version of the Early Worry Questionnaire (EWQ) was constructed. An iterative process involving parents and teachers completing workshops and subsequent testing facilitated a re-modeling of the method.ResultsIn the resulting Dialogue Based Early Detection a 36-item version of EWQ was completed by both parents and teachers ahead of the annual parent-teacher meeting. During that meeting the participants should try to reach a consensus whether there was a concern, some uncertainty, or no worry for the child, and which appropriate actions should be taken for a possible follow up. Both parents and teachers reported that the EWQ supported them in verbalizing already existing worries for the child. Teachers reported that parents were better prepared and participated more actively in the evaluation meetings. However, some parents complained that there was too much focus on possible worries. During the testing, challenges of language development, conduct, emotional reactions, toileting, attention, and eating were detected among the children.ConclusionThe Dialogue Based Early Detection method was endorsed by both teachers and parents and holds promise as a tool for improving early awareness and identification of developmental and mental health problems of preschool children in daycare centers.
Associations Among Workplace Bullying, Resilience, Insomnia Severity, and Subjective Wellbeing in Chinese Resident Doctors
Authors: Zhou Shaojiong , Chen Jia , Lin Han , Ye Ying , Xiao Yu , Ouyang Na , Pan Shaomei , Feng Siqi , Xie Meiling , Li Bingxian 
Published: February 2022

BackgroundAlthough workplace bullying is common among medical workers, its associations with insomnia severity and subjective wellbeing are still unclear. Our study aimed to investigate these associations among resident doctors who are more vulnerable to both workplace bullying and insomnia.MethodsWe conducted a cross-sectional survey of 1,877 resident doctors from 12 hospitals across 7 administrative regions in China. Workplace bullying, resilience, insomnia severity, and subjective wellbeing were evaluated by the Negative Acts Questionnaire-Revised (NAQ-R), the Chinese version of the Connor-Davidson Resilience Scale-10-item (CD-RISC-10), the Insomnia Severity Index, and the Index of Wellbeing, respectively. Further, a logistic regression analysis was used to analyze factors associated with insomnia. In addition, structural equation modeling (SEM) was applied to examine the associations among workplace bullying, resilience, insomnia severity, and subjective wellbeing.ResultsIn the present study, the rates of workplace bullying and insomnia were 51.4 and 33.2%, respectively. Workplace bullying (OR = 1.056, p &lt; 0.001) and poor resilience (OR = 0.957, p &lt; 0.001) were the factors associated with insomnia after controlling the confounding variables. Further, SEM of the present study revealed a direct relationship between workplace bullying and subjective wellbeing (std-β = −0.223, p &lt; 0.001). In addition, insomnia severity (std-β = −0.071, p &lt; 0.001) and resilience (std-β = −0.092, p &lt; 0.001) can individually or collectively (std-β = −0.008, p &lt; 0.001) mediate the indirect associations between workplace bullying and subjective wellbeing. However, resilience was found to act as a moderator only in the direct association between workplace bullying and subjective wellbeing.ConclusionsWorkplace bullying and poor resilience were the factors associated with insomnia. Further, greater resilience acted as a buffer in the direct association between workplace bullying and subjective wellbeing, whereas both insomnia severity and resilience were critical mediators in the indirect associations between them.
Effect of Home Enteral Nutritional Support Compared With Normal Oral Diet in Postoperative Subjects With Upper Gastrointestinal Cancer Resection: A Meta-Analysis
Authors: Liu Fang , Pan Xuling , Zhao SuQing , Ren RuiJun , Chang GuiXia , Mao Yu 
Published: February 2022

IntroductionWe performed a meta-analysis to evaluate the influence of a home enteral nutritional support compared with a normal oral diet in postoperative subjects with upper gastrointestinal cancer resection.MethodsA systematic literature search up to December 2021 was done and 23 studies included 3,010 subjects with upper gastrointestinal cancer resection at the start of the study; 1,556 of them were given home enteral nutritional support and 1,454 were normal oral diet. We calculated the odds ratio (OR) and mean difference (MD) with 95% CIs to evaluate the influence of home enteral nutritional support compared with a normal oral diet in postoperative subjects with upper gastrointestinal cancer resection by the dichotomous or continuous methods with a random or fixed-influence model.ResultsHome enteral nutritional support had significantly higher quality of life (MD, 2.08; 95% CI, 1.50–2.67, p &lt; 0.001), better body weight change (MD, 1.87; 95% CI, 1.31–2.43, p &lt; 0.001), higher albumin (MD, 1.27; 95% CI, 0.72–1.82, p &lt; 0.001), and higher pre-albumin (MD, 30.79; 95% CI, 7.29–54.29, p = 0.01) compared to the normal oral diet in subjects with upper gastrointestinal cancer resection. However, home enteral nutritional support had no significant impact on the hemoglobin (MD, 4.64; 95% CI, −4.17 to 13.46, p = 0.30), and complications (OR, 1.03; 95% CI, 0.76–1.40, p = 0.83) compared to the normal oral diet in subjects with upper gastrointestinal cancer resection.ConclusionsHome enteral nutritional support had a significantly higher quality of life, better body weight change, higher albumin, and higher pre-albumin, and had no significant impact on the hemoglobin and complications compared to the normal oral diet in subjects with upper gastrointestinal cancer resection. Further studies are required.
Is Single Nucleotide Polymorphism ADIPOQ (NM_004797.4):c.214+62G>T (rs1501299) Associated With Uterine Leiomyomas? A Pilot Study
Authors: Bieńkiewicz Jan , Smolarz Beata , Wilczyński Miłosz , Stepowicz Anna , Jabłoński Grzegorz , Obłękowska Anna , Malinowski Andrzej , Romanowicz Hanna 
Published: February 2022

Objective: Although polymorphisms of adiponectin gene (ADIPOQ) in obesity-related conditions have been the target of research efforts, little is known about this genetic marker in uterine leiomyomas. The aim of this pilot study was to analyze the frequencies of alleles and genotypes of Single Nucleotide Polymorphism ADIPOQ (NM_004797.4):c.214+62G&gt;T (rs1501299) and to correlate it with the risk of uterine fibroids.Study Design: The Test Group comprised 90 women treated surgically for uterine leiomyomas in the Department of Operative Gynecology, Endoscopy and Gynecologic Oncology, Polish Mother’s Memorial Hospital-Research Institute. 90 disease-free individuals were used as Controls. Patients within both groups were additionally stratified into lean, overweight and obese, according to Body Mass Index. Statistical analysis was performed between the two major groups and, furthermore, within the abovementioned subgroups.Results: The study revealed no statistically significant differences in the distribution of alleles and genotypes of SNP ADIPOQ (NM_004797.4):c.214+62G&gt;T (rs1501299) between the two main groups. A weak correlation within distributions of alleles was observed between obese Test Patients and lean Controls.Conclusion: This pilot study has revealed no association between SNP ADIPOQ (NM_004797.4):c.214+62G&gt;T (rs1501299) and uterine fibroids. Further studies on larger groups are warranted to elucidate whether this SNP may be correlated with uterine leiomyomas.
Survey of the Solidago canadensis L. Morphological Traits and Essential Oil Production: Aboveground Biomass Growth and Abundance of the Invasive Goldenrod Appears to Be Reciprocally Enhanced within the Invaded Stands
Authors: Baranová Beáta , Troščáková-Kerpčárová Eva , Gruľová Daniela 
Published: February 2022

Canadian goldenrod is one of the most widespread invasive neophytes in Europe with proven ecological and environmental consequences for the invaded plots. The morphological traits and productive features survey can offer a better insight view into the S. canadensis population ecology and the dynamic of its aboveground biomass growth. Equally, it can serve as a foundation for a balanced management proposal, with the aim of keeping an acceptable degree of Canadian goldenrod invasion. In the study, 600 specimens, collected at various phenological phases, from the twelve sampling stands in the eastern Slovakia, were processed. The obtained data were related to the degree of invasion, pH, soil moisture, overall stand area, and measure of interventions. Plants from the stands with a mild degree of goldenrod invasion (<50%), lower pH, and higher stand area were significantly lower and lighter; had a significantly lower number and weight of leaves; significantly shorter and lighter stems, in comparison to the plants from the stands with a heavy degree of invasion (>50%); a higher pH; and a smaller area. These plants also showed smaller essential oil productivity rate, and they achieved the growth peak a significantly later. Conversely, as the stand area decreased, and the S. canadensis % representation and soil reaction increased, goldenrods became significantly taller and heavier, with a higher number of leaves and a higher essential oil productivity rate. Canadian goldenrod shows, somewhat, a cyclical, self-growth-reinforcing feedback: the consecutive increase of the goldenrod’s aboveground biomass leads to an increase of its relative % abundance within the invaded stands. Consequently, the increase of the goldenrod’s relative % abundance leads to the plants aboveground biomass consecutive growth, and so on.
Alignment of Science and Technology With Islamic Principles Using Quantum Theory
Authors: Alwiyah Alwiyah , Husin Syarief Nur , Padeli Padeli , Anggaraeni Mey , Sulistiawati Sulistiawati 
Published: February 2022

The wave-particle duality stranges and it is in dire need. This theory is put forward method based on the Koran and complemented by rational philosophical arguments. Explaining relevant Quranic verses, as well as the one-to-one relationship between the concept of pairing and the interviewee's principle, will help explain of the electron in detail. Shows that electrons all of which reflect the behavior of the wave-particle duality observed in experiments. Although physicists consider a magnet and the existence of a magnetic field caused by the rotation of electrons, a new theory speculates that there has also been a permanent magnetic field recently. In addition, the choice of gate charge and permanent magnets can be selected as potential energy which is also considered as possible which has been observed to exist but has not been well described. Equations have been derived electrons. In this respect, Islamic science and technology seems to have demonstrated the importance of exploring the mysterious quantum world.