bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insecticide-treated eave nets and window screens for malaria control in Chalinze district, Tanzania: a study protocol for a household randomised control trial
Authors: Odufuwa Olukayode G. , Moore Sarah Jane , Mboma Zawadi Mageni , Mbuba Emmanuel , Muganga Joseph Barnabas , Moore Jason , Philipo Rose , Rashid Mohammed Ally , Bosselmann Rune , Skovmand Ole , Bradley John 
Published: July 2022

Abstract
Background
Long-lasting insecticidal nets (LLINs) have contributed to the reduction of malaria in sub-Saharan Africa, including Tanzania. However, they rely on daily user behaviour and high coverage which is difficult to maintain. Also, insecticide resistance among malaria vector mosquitoes is contributing to reduced efficacy of control tools. To overcome these problems, we propose to evaluate a new tool for house modification, the insecticide-treated eave nets (ITENs) in combination with insecticide-treated window screens (ITWS) incorporated ﻿with dual active ingredient (dual AI) for the control of malaria.

Methods
Four hundred and fifty (450) households with intact walls, open eaves without screens or nets on the windows in Chalinze district will be eligible and recruited upon written informed consent. The households will be randomly allocated into two arms: one with ITENs and ITWS installed and the other without. Malaria parasite detection using a quantitative polymerase chain reaction (qPCR) will be conducted shortly after the long rain (June/July, 2022) as the primary outcome and shortly after the short rain (January/February, 2022) as the secondary outcome. Other secondary outcomes include clinical malaria cases, and density of malaria vectors and nuisance after the short rain and long rain. In addition, surveys will be conducted in households with ITENs and ITWS to estimate the intervention’s cost during installation, adverse effects one month after installation, and presence, fabric integrity and user acceptance six and twelve months after installation. Bioefficacy and chemical content will be evaluated twelve months after installation.

Discussion
ITENs and ITWS have been shown in Kenya to reduce indoor mosquito density. However, it is not known if indoor mosquito density reduction translates into reduction of malaria cases. Data from the study will measure the potential public health value of an additional intervention for malaria control at the household level in areas of mosquito insecticide resistance that does not require daily adherence.

Trial registration
The study is registered on ClinicalTrials.gov.
Decreasing delirium through music listening (DDM) in critically ill, mechanically ventilated older adults in the intensive care unit: a two-arm, parallel-group, randomized clinical trial
Authors: Seyffert Sarah , Moiz Salwa , Coghlan Matthew , Balozian Patil , Nasser Jason , Rached Emilio Abi , Jamil Yasser , Naqvi Kiran , Rawlings Lori , Perkins Anthony J. , Gao Sujuan , Hunter J. Downs , Khan Sikandar , Heiderscheit Annie , Chlan Linda L. , Khan Babar 
Published: July 2022

Abstract
Background
Delirium is a highly prevalent and morbid syndrome in mechanically ventilated intensive care unit (ICU) patients. Music is a promising non-pharmacological intervention with beneficial effects on anxiety and stress, while its effects on delirium duration and severity are not well understood.

Methods/design
Our study is a two-arm, randomized parallel-group, clinical trial to evaluate the efficacy of music intervention compared to a silence-track attention control on delirium/coma duration in mechanically ventilated critically ill older adults.
One hundred sixty mechanically ventilated adults 50 years of age or older will be randomized to one of two arms within 72 h of ICU admission: (1) 1-h music listening sessions twice daily through noise-canceling headphones, or (2) 1-h sessions of a silence track twice daily through noise-canceling headphones. Our primary aim is to compare delirium/coma-free days after randomization during the 7-day study intervention phase using the Confusion Assessment Method for the ICU (CAM ICU) and the Richmond Agitation Sedation Scale (RASS) for delirium and coma. Secondary outcomes include pain and anxiety evaluated twice daily during the intervention phase and throughout the duration of ICU stay using the Critical Care Pain Observation Tool (CPOT) and visual analog scale-anxiety (VAS-A). Enrolled participants will be followed after hospital discharge to further measure cognition as well as screening for depression and anxiety using the following telephone-based instruments: Indiana University Telephone-Based Assessment of Neuropsychological Status (IU TBANS), Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder-7 (GAD-7).

Discussion
This randomized clinical trial will measure the efficacy of a music listening intervention for delirium and coma duration early in the intensive care unit among older adults.

Trial registration.
ClinicalTrials.gov. NCT04182334.
Effects of photobiomodulation on re-epithelialization of burn wound: protocol for a randomized controlled trial
Authors: de Araújo Pereira Venceslau Silvana Cristina , Ferreira Júlia Lacet Silva , Barros Renata Maria Freire , de Morais Ronny Marcos , dos Santos Heleodório Honorato , de Oliveira Valéria Mayaly Alves , de Andrade Palloma Rodrigues 
Published: July 2022

Abstract
Background
Burns are a global public health problem and cause approximately 180,000 deaths annually, mainly in low- and middle-income countries. Topical antibiotics and occlusive dressing are standard treatments for burns not requiring a skin graft. However, physiotherapy has low-cost phototherapeutic and electrophysical resources (e.g., light-emitting diode [LED]) that may accelerate burn healing. This study aims to compare the re-epithelialization rate of second-degree burns, pain, pruritus, skin temperature, quality of wound healing, and scar quality and mobility among individuals undergoing treatment with red LED, infrared LED, and simulated photobiomodulation.

Methods
This is a double-blinded, three-arm parallel-group, randomized controlled superiority trial. Individuals of both sexes, aged over 18 years, and with second-degree burns will be included. The sample will be divided into three groups of 13 individuals: two will receive LED therapy (red or infrared) and one placebo. Pain, pruritus, skin temperature, and wound size will be assessed daily. Interventions will take place until complete healing, when scar mobility and quality will be evaluated. Data will be presented as mean and 95% confidence interval and analyzed using mixed linear models.

Discussion
This randomized controlled trial has minimal risk of bias and intends to identify the ideal type, procedures, and doses of photobiomodulation to heal burns, which are not standardized in clinical practice. Positive results will allow the implementation of the technique in burn and wound guidelines.

Trial registration
Brazilian Clinical Trials Registry (ReBEC) RBR-8bfznx6. Registered on October 13, 2021
Manual acupuncture as prophylaxis for migraine without aura: study protocol for a multi-center, randomized, single-blinded trial
Authors: Chen Jiao , Zhou Siyuan , Sun Mingsheng , Wang Yanan , Chen Xiaoqin , Guo Taipin , Liu Lu , Luo Jing , Ni Xixiu , Yang Xuguang , Li Dehua , Gao Shan , He Zhenxi , Cai Dingjun , Zhao Ling 
Published: July 2022

Abstract
Background
Migraine is a highly prevalent neurological disorder. It is the third most prevalent disorder and the seventh highest cause of disability worldwide. Acupuncture may be a viable prophylactic treatment option for frequent or uncontrolled migraine. Clinical studies comparing acupuncture and placebo acupuncture have not reached a consistent conclusion in confirming whether acupuncture is effective in migraine prophylaxis. The effect of acupuncture mainly depends on acupoints and needles operation. We found that the design of the placebo acupuncture in previous studies included shallow needling at sham acupoints, non-penetrating needling at sham acupoints, and needling at inactive acupuncture points to achieve the inert effect of control group, but the non-penetrating needling at true acupoints was ignored. This randomized controlled trial aims to use true acupoints for non-penetrating acupuncture as control to evaluate the efficacy of manual acupuncture for the prophylaxis of migraine without aura (MWoA).

Methods/design
This is a single-blinded, randomized, controlled, prospective, multi-center trial with two parallel treatment groups. A total of 198 eligible patients with MWoA will be randomly divided into two groups (1:1 allocation ratio). The intervention group will receive manual acupuncture and the control group will receive placebo acupuncture (non-penetrating). Patients will receive three acupuncture treatment sessions per week for 4 consecutive weeks. All patients will then receive a 12-week follow-up.

Discussion
In this study, we are evaluating the efficacy and safety of manual acupuncture in the prophylaxis of MWoA. The placebo control is using non-penetrating needling verum acupoints. It is essential to determine an appropriate control method to ensure the methodological quality of a randomized controlled trial.

Trial registration
The trial has been registered in the Chinese Clinical Trial Registry (approval no. ChiCTR2000032308) in April 2020.
Robotic-Assisted Esophagectomy Leads to Significant Reduction in Postoperative Acute Pain: A Retrospective Clinical Trial
Authors: Hoelzen Jens P. , Sander Karl J. , Sesia Matteo , Roy Dhruvajyoti , Rijcken Emile , Schnabel Alexander , Struecker Benjamin , Juratli Mazen A. , Pascher Andreas 
Published: July 2022

Abstract
Background
Robot-assisted minimally invasive esophagectomy (RAMIE) shows promising results regarding postoperative complications in patients with esophageal cancer. To date, no data are available regarding postoperative analgesic consumption. The aim of this work is to evaluate analgesic consumption after esophagectomy.

Methods
A total of 274 Ivor Lewis esophageal resections performed sequentially from January 2012 to December 2020 were evaluated. RAMIE cases (n = 51) were compared with the hybrid technique (laparoscopic abdominal phase followed by open thoracotomy, n = 59) and open abdominothoracic esophagectomy (OTE) (n = 164). Data were collected retrospectively. The primary endpoint was the overall postoperative morphine consumption, which represents a reliable indirect measurement of pain. Pain levels recorded on the first, third, and fifth postoperative days were assessed as secondary endpoints.

Results
A total of 274 patients were included. The postoperative opioid consumption rate for patients who underwent RAMIE (quartiles: 0.14, 0.23, 0.36 mg morphine milligram equivalents (MME)/kg body weight (bw)/day) was significantly lower than in the open group (0.19, 0.33, 0.58 mg MME/kg bw/day, p = 0.016). The overall postoperative opioid consumption for patients who underwent RAMIE was significantly lower (2.45, 3.63, 7.20 mg MME/kg bw/day; morphine milligram equivalents per kilogram body weight) compared with the open (4.85, 8.59, 14.63 MME/kg bw/day, p < 0.0001) and hybrid (4.13, 6.84, 11.36 MME/kg bw/day, p = 0.008) groups. Patients who underwent RAMIE reported lower pain scores compared with the open group on the fifth postoperative day, both at rest (p = 0.004) and while performing activities (p < 0.001).

Conclusions
This study shows that patients who underwent RAMIE experienced similar postoperative pain while requiring significantly lower amounts of opioids compared with patients who underwent open and hybrid surgery. Further studies are required to verify the results.
Phenanthrodiazaporphyrins: 1,10-Phenanthroline-Embedded Diazaporphyrin Analogues
Authors: Chan Joseph Y M , Okada Yusuke , Yoshida Satsuki , Kawata Takahiro , Kobayashi Nagao , Ng Dennis K P 
Published: July 2022

Abstract
A series of metal-free and metallo-diazaporphyrin analogues embedded with a 1,10-phenanthroline unit were synthesized and characterized. The molecular structure of the Ni(II) complex determined by single-crystal X-ray diffraction analysis confirmed its monocationic character in which the metal center adopts a typical square planar geometry binding with the pyrrole and phenanthroline nitrogen atoms. The spectroscopic and electrochemical studies, as well as molecular orbital calculations suggested that the metal complexes can be classified as 4nπ non-aromatic compounds.
Classroom-Based Physical Activity and On-Task Behavior
Authors: Mahar Matthew T. 
Published: July 2022

ABSTRACT
Schools are valuable locations to promote physical activity because most children are in school for large portions of the day and year. However, the main objective of most schools is to teach academic skills. For school personnel to implement classroom-based physical activity programs, they need to be convinced that these programs will help the students learn better. Teachers understand and value the concept of on-task behavior or paying attention. Without attentional focus, students do not learn. Thus, if research demonstrates that participation in classroom-based physical activity programs enhances on-task behavior, teachers may be more likely to implement these programs. Although on-task behavior in the authentic classroom setting is difficult to measure, the accumulated evidence about the effect of classroom-based physical activity on on-task behavior is convincing. This article presents an overview of measurement issues associated with directly observed on-task behavior in schools and a summary of the key studies that have made a substantial contribution to the literature in this field. Various research designs and statistical comparisons have been used to examine these relationships. Several research studies have included examination of the effect of physical activity on on-task behavior within subgroups of students (e.g., level of attention, sex, fitness, race/ethnicity, and socioeconomic status). In summary, research demonstrates that classroom-based physical activity enhances on-task behavior compared with traditional sedentary learning environments, and this benefit appears to hold for all subgroups of students that have been examined. Specific suggestions to enhance the implementation of classroom-based physical activity and to further develop the research base are provided.
Validación psicométrica de la batería UNIPSICO en valenciano/catalán: análisis de las escalas que evalúan las variables psicosociales de demanda
Authors: Llorca-Rubio José Luis , Llorca-Pellicer Marta , Gil-Monte Pedro R. , Gil-LaOrden Pedro 
Published: July 2022

Objetivo: Analizar las propiedades psicométricas de las escalas de demandas de la batería UNIPSICO del contexto de trabajo en valenciano/catalán.
Método: La muestra la constituyen 2114 trabajadores de centros públicos de la Generalitat Valenciana, de la provincia de Valencia. La recogida de datos se realizó mediante las escalas de la batería UNIPSICO que evalúan factores psicosociales de demandas en el trabajo (33 ítems), que se agrupan en 6 escalas: Conflicto de rol (5 ítems), ambigüedad de rol (5 ítems), carga de trabajo (6 ítems), conflictos interpersonales (6 ítems), inequidad en los intercambios sociales (5 ítems), y conflicto trabajo-familia/familia-trabajo (6 ítems). Se realizó un análisis factorial confirmatorio (AFC) y se calcularon los valores alfa de Cronbach y omega de McDonald para las escalas.
Resultados: Todos los ítems presentaron valores estadísticos y psicométricos adecuados. El modelo de seis factores que reproduce la estructura original del cuestionario presentó un ajuste adecuado a los datos, con invarianza de sexo. El valor del alfa de Cronbach y omega de McDonald resultó aceptable para las seis escalas del instrumento.
Conclusiones: Estos resultados contribuyen a la validación psicométrica del cuestionario, permitiendo concluir que las escalas de demandas de la batería UNIPSICO, en valenciano/catalán resulta un instrumento fiable y con consistencia interna para evaluar los riesgos psicosociales en personal que trabaja en la administración.
Implementing a self-monitoring application during pregnancy and postpartum for rural and underserved women: A qualitative needs assessment study
Authors: Vernon Marlo M. , Yang Frances M. 
Published: July 2022

Background
Georgia has one of the highest maternal mortality rates within the US. This study describes the qualitative needs assessment undertaken to understand the needs of rural and underserved women and their perspectives on implementing a self monitoring application during pregnancy and postpartum.

Methods
Qualitative methodology was used to conduct the needs assessment of 12 health care providers (nurses, nurse-midwives, patient care coordinators, and physicians) and 25 women from rural and underserved populations in Georgia was conducted to ascertain common themes on three topics: pregnancy care experiences, comfort with technology, and initial perspectives on the proposed VidaRPM application. Transcription, coding, and consensus were conducted using content analysis and a Cohen’s Kappa coefficient was calculated to identify level of overall agreement between raters for the representative quotes identified for each theme.

Results
The overall agreement for the representative quotes that were chosen for each theme was in strong agreement (κ = 0.832). The major provider feedback included the following regarding the VidaRPM app: inclusion of questions to monitor physical well-being, embedded valid and reliable educational resources, and multiple modalities. The overall feedback from the mothers regarding the VidaRPM application was the virtual aspect helped overcome the barriers to accessing care, comfort with both WiFi and technology, and sustainable utility.

Discussion
The needs of rural and underserved pregnant women and their providers were assessed to develop and refine the VidaRPM app. This qualitative study on the VidaRPM app is the first step towards closing the gap between providers and patients during prenatal and postpartum periods by empowering and educating women into the first-year postpartum living in rural and underserved areas.
The impact of cognitive impairment of individuals with Parkinson’s disease on their caregivers’ mental health: A systematic review protocol
Authors: Golińska Paulina Beata , Bieleninik Łucja , Harciarek Michał , Bidzan Mariola 
Published: July 2022

Introduction
Parkinson’s disease is a motor disease, the second most common neurodegenerative disorder with cardinal symptoms including bradykinesia, rigidity, and rest tremor accompanied by cognitive difficulties. The caregivers play a crucial role for individuals with Parkinson’s disease; however, many of them may suffer from high caregiver burden and mental health deterioration. This protocol of a systematic review presents a methodology of the review about the impact of cognitive impairment of individuals with Parkinson’s disease on their caregivers’ mental health.

Material and methods
Research will be identified by combining electronic databases searching and hand searching. The following databases will be included: Medline, PsycInfo, Web of Sciences, Cochrane, CINAHL, Embase and Scopus. The inclusion and exclusion criteria followed to PECOS model. The population of informal caregivers is defined as family members providing care on a patient with Parkinson’s disease. Exposure is linked with the evaluation of a cognitive functioning and outcome is defined as mental health among caregivers of individuals with Parkinson’s disease. We will include two types of studies: observational and intervention. Both, screening and eligibility will be done by two independent reviewers. Study quality will be assessed by two authors independently. Data will be extracted by two reviewers independently and will follow a pre-pilot extraction form. Any discrepancies will be resolved by discussion or/and consultation with another reviewer. The synthesis without meta-analysis (SWiM) guidelines will be used to report on included studies data. The metanalysis with usage the statistical software R version 4.1.2 (2021-11-01) “Bird Hippie” and R metaphor package 3.0–2 of will be conducted if possible.

Discussion
The goal of this systematic review is to present the association between caregivers’ mental health problems and their proteges’ cognitive impairment. It will enable to identify the gaps in literature and its methodology giving the suggestions for further research.

Protocol registration
Protocol registration number in PROSPERO: CRD42022296670
Having siblings promotes a more healthy weight status—Whereas only children are at greater risk for higher BMI in later childhood
Authors: Bohn Claudia , Vogel Mandy , Poulain Tanja , Hiemisch Andreas , Kiess Wieland , Körner Antje 
Published: July 2022

Background
Birth order and having at least one sibling are known to be associated with an increased risk for development of overweight. However, there are no studies assessing pre- and postnatal factors for developing overweight within families. Therefore, the present study aimed to analyse the association of the mother’s weight gain during pregnancy, prepregnancy BMI, mother’s age at birth, breastfeeding, age gap between siblings, and physical activity together with sibling-related characteristics on the development of overweight in children and adolescents.

Methods
Data were obtained from the longitudinal LIFE Child cohort. The study sample included n = 1932 children, stratified into first-born (n = 578), second-born (n = 608), third-or-later-born single-born siblings (n = 162), only children (n = 526), and twin children (n = 58). Children with chronic or syndromic diseases, born prematurely or from mothers with gestational diabetes were excluded. Data were adjusted for multiple children per family using mixed models. Pregnancy weight gain, prepregnancy BMI and mother’s age were considered prenatal co-variates. Postnatal factors included the duration of breastfeeding and the children’s physical activity level.

Results
Particularly until the onset of puberty, the BMI-SDS differed between single-born siblings, only children and twins, and increased with birth order. Compared to children with siblings, only children exhibited a strong increase in BMI-SDS starting at age nine. A higher age gap between siblings was associated with a higher BMI-SDS in second- and third-or-later-born children. Single-born siblings had the highest rate and duration of breastfeeding. Physical activity was highest in twins and third-or-later-born children and lowest in only children. In a multivariate model, being an only child showed a highly significant association with BMI-SDS.

Conclusion
The present study demonstrated that siblings had a lower BMI-SDS than only children did. For single-born siblings, the association between birth order and increased BMI-SDS seemed to persist only up to 11 years of age.