bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum levels of VEGF-A, sVEGFR-2 and galectin-3 do not correlate with clinical stage, tumor size,
or effectiveness of perioperative chemotherapy in patients with non-metastatic breast cancer
Authors: Grochoła-Małecka Iga , Czajka-Francuz Paulina , Owczarek Aleksander , Wojnar Jerzy , Handzlik Gabriela , Francuz Tomasz , Chudek Jerzy 
Published: September 2022

WstępAngiogeneza nowotworowa jest procesem regulowanym przez wiele cytokin i czynników wzrostu, spośród których znaczącą rolę odgrywają czynnik wzrostu śródbłonka naczyń (<i>vascular endothelial growth factor</i> – VEGF), drugi rozpuszczalny receptor dla śródbłonkowego czynnika wzrostu (<i>soluble vascular endothelial growth factor receptor 2</i> – sVEGFR-2) i galektyna-3. Dane literaturowe dotyczące oceny zmian stężenia VEGF, sVEGFR-2 oraz galektyny-3 w trakcie chemioterapii (<i>chemotherapy</i> – CTH) raka piersi (<i>breast cancer</i> – BC) są niejednoznaczne. Celem niniejszej pracy była analiza stężenia VEGF-A, sVEGFR-2 oraz galektyny-3 w surowicy pacjentek z rakiem piersi, rozpoczynających adjuwantową i neoadjuwantową chemioterapię oraz ocena zmian stężenia tych cytokin w trakcie leczenia.Materiał i metodyJednoośrodkowe badanie objęło 98 pacjentek z miejscowo zaawansowanym rakiem piersi, w tym 56 poddanych adjuwantowej i 42 neoadjuwantowej terapii. Stężenie VEGF-A, sVEGFR-2 i galektyny-3 w surowicy krwi oceniono na początku leczenia oraz po 2 miesiącach terapii.WynikiNie stwierdzono istotnych różnic pomiędzy stężeniami VEGF-A, sVEGFR-2 oraz galektyny-3 w surowicy pacjentek poddanych adjuwantowej i neoadjuwantowej chemioterapii. Nie wykazano również zależności między stężeniem tych cytokin w surowicy a stopniem zaawansowania klinicznego raka piersi. W trakcie przedoperacyjnej chemioterapii odnotowano znaczące zwiększenie stężenia VEGF-A, sVEGFR-2 i galektyny-3, jednakże zarówno wyjściowe stężenia cytokin, jak i zmiany w czasie nie miały znaczenia predykcyjnego dla uzyskania całkowitej odpowiedzi patologicznej.WnioskiStężenia VEGF-A, sVEGFR-2 oraz galektyny-3 w surowicy nie korelują ze stopniem zaawansowania klinicznego ani masą nowotworu u pacjentek z miejscowo zaawansowanym rakiem piersi. Wyjściowe stężenia VEGF-A, sVEGFR-2 i galektyny-3 oraz zaobserwowany wzrost stężeń tych cytokin w surowicy w trakcie chemioterapii nie mają wartości predykcyjnej dla jej skuteczności.
ОЦЕНКА ЗАПАСА ДРЕВОСТОЕВ НА ЗЕМЛЯХ ЛЕСНОГО ФОНДА С УЧЕТОМ АНТРОПОГЕННЫХ РИСКОВ: ПРОГРАММНО-МЕТОДИЧЕСКОЕ ОБЕСПЕЧЕНИЕ
Authors: Лепихина Ольга Юрьевна , Демидова Полина Михайловна , Колесник Ольга Александровна , Ковязин Василий Фёдорович , Гурьева Ольга Сергеевна , Басова Лидия Алексеевна 
Published: September 2022

Актуальность. Задача обеспечения автоматизированного учета, оценки и прогноза запаса лесных ресурсов является одной из важнейших направлений государственной стратегии развития лесного комплекса. Создание автоматизированной информационной системы по геодезическим данным, способной реализовывать качественный и полноценный информационный процесс по сбору, обработке, анализу, моделированию, прогнозу и визуализации пространственно-временных данных о состоянии лесных ресурсов с учетом основных рисков лесного хозяйства, является одним из важных механизмов повышения эффективности лесопользования. Цель: создание методического и программного обеспечения оценки запаса древесных ресурсов на землях лесного фонда с учетом антропогенных рисков. Объекты: лесные насаждения Чернореченского участкового лесничества Всеволожского лесничества Ленинградской области. Методы. На основе применения методов регрессионного моделирования получены математические модели зависимости запаса насаждений различных древесных пород от среднего возраста древостоя в лесном выделе; в основу разработанного программного обеспечения заложены авторские методические решения по оценке и прогнозу запаса древесины. Результаты. Применение полученных зависимостей для Чернореченского лесничества Всеволожского района Ленинградской области позволило рассчитать значения запаса древесины по состоянию на 2011 и 2021 гг., а также спрогнозировать его значения на 2031 г. Предложена методика оценки ущерба пожара на землях лесного фонда на основе интегрального показателя риска. Автоматизация расчета данного показателя в созданной программе позволила осуществить дифференциацию земель лесничества по трем классам риска пожаров. Сформирована карта зонирования территории объекта исследования по риску сплошных и самовольных рубок леса. Созданное программно-методическое обеспечение может служить основой для реализации одного из главных направлений стратегии развития лесного комплекса России в части создания единой федерально-информационной системы учета и прогноза текущего прироста запаса древесных ресурсов лесного фонда.
A long time follow-up of the expanding bilateral sphenoid sinus plasty application in the treatment of refractory sphenoid sinusitis
Authors: Xue Fei , Yu Xiang , Cheng You , Wu Minghai , Ji Junfeng , Wang Zhiyi , Xu Li , Wang Rui 
Published: September 2022

Abstract
Background
The expanding bilateral sphenoid sinus plasty is an essential technique in the treatment of refractory sphenoid sinusitis. The aim of the present study was to explore the application of expanding bilateral sphenoid sinus plasty in the treatment of refractory sphenoid sinusitis.
Methods
Retrospective medical record review in a tertiary-care university hospital of 15 patients treated with the expanding bilateral sphenoid sinus plasty between December 2012 and December 2020. A follow-up of the surgical effect and complications were conducted. Primary outcomes evaluated were overall and disease-free survival. The end points assessed were presence of positive surgical margins, development of local, and regional recurrences.
Results
The patients were followed up for 12–73 months, with an average follow-up time of 28.5 ± 9.6 months. 15 cases of refractory sphenoid sinusitis were cured with well opened sphenoid sinus orifice and clean cavity. Of all the 15 cases, the symptoms were relieved after operation except preoperative hyposmia in 2 and impaired vision in one with no obvious improvement. No complications such as nasal bleeding, olfactory hypofunction and perforation of nasal septum occurred. Follow up revealed a better mucosal epithelization in all the patients within an average time of 8.6 weeks. Endoscopic sinus reexamination showed that the sphenoid sinus orifice was well opened, and no case of sphenoid sinus orifice closure was observed.
Conclusion
This study is a case series of a long time follow-up of the expanding bilateral sphenoid sinus plasty application in the treatment of refractory sphenoid sinusitis. With the advantages of easily intraoperative positioning, clearly exposed surgical field, full opening of sinus cavity, high surgical safety, short epithelialization time and intuitionistic postoperative follow-up, the expanding bilateral sphenoid sinus plasty is an improved way of treating refractory sphenoid sinusitis.
Implications:
This technique is worth being explored by surgeons for better surgical outcome.
Identification of Bactrian camel milk-related genes and regulatory networks in supplementation and grazing
Authors: Guo Lili , Lema Dao , Liu Bin , Dai Lingli , Wang Xue , Wang Xiaoshan , Cao Junwei , Zhang Wenguang 
Published: September 2022

Abstract
Using gene co-expression networks to understand dynamic characterizations in lactating animals becomes a common method. However, there are rarely reporters focusing on milk traits in Bactrian camel by high-throughput sequencing. We used RNA-seq to generate the camel transcriptome from the blood of 16 lactating Alxa Bactrian Camel in different feeding groups. In total, we obtained 1185 milk-related genes correlated with milk yield, milk protein, milk fat, and milk lactose across the WGCNA analysis. Moreover, 364 milk-related genes were differentially expressed between supplementation and grazing feeding groups. The DE-CMRGs in supplement directs an intensive gene co-expression network to improve milk performance in lactating camels. This study provides a non-invasive method to identify the camel milk-related genes in camel blood for four primary milk traits and valuable theoretical basis and research ideas for the study of the milk performance regulation mechanism of camelid animals.
AmPIF4 negatively regulates the blue light-induced synthesis of volatile terpenoids in snapdragon
Authors: Li Tong , Han Jianing , Wang Xuelian , Wu Jing , Leng Pingsheng , Hu Zenghui 
Published: September 2022

Abstract
Background
Floral secondary metabolites, especially terpenoids, play a key role in plant defense and reproduction. Terpenoids are the most abundant floral volatiles, and their synthesis and release are affected by light quality. Blue light can significantly enhance the emissions of terpenoids as well as the expression of biosynthesis-related genes in snapdragon. However, the regulatory mechanism of blue light-induced terpenoid biosynthesis remains unclear.
Results
In this study, the transcription factor (TF) PHYTOCHROME-INTERACTING FACTOR 4 (AmPIF4) was identified and found to be lowly expressed under blue light, which was in contrast to the expression of ocimene synthase (AmOCS) and myrcene synthase (AmMYS), 1-deoxy-D-xylulose 5-phosphate (DXP) synthase (AmDXS), and DXP reductoisomerase (AmDXR). AmOCS and AmMYS expression and the relative emissions of ocimene and myrcene were up-regulated in response to AmPIF4 silencing. Moreover, AmPIF4 negatively regulated terpenoid biosynthesis by binding to the promoters of biosynthesis-related genes. The transcriptional activation activity of AmPIF4 was increased in AmCRY1-silenced flowers. In addition, AmPIF4 interacted with AmCRYs (Cryptochromes) and AmCOP1 (CONSTITUTIVELY PHOTOMORPHOGENIC 1), which are key blue light signal receptors.
Conclusion
Overall, our results reveal a novel molecular mechanism involving AmPIF4 that contributes to the blue light-mediated regulation of terpenoid biosynthesis in snapdragon.
Haumanu Hauora: Refining public health institution policy to include Māori and climate change
Authors: Masters-Awatere Bridgette , Howard Darelle , Young Patricia 
Published: September 2022

Abstract
The deepening climate crisis generates specific impacts that will exacerbate the already disproportionately negative health outcomes experienced by Indigenous. These disparate health outcomes have not spontaneously emerged, but rather have been foreshadowed by existing inequities. This article summarises a sample of the work undertaken as part of a two-year research project inNew Zealand to understand existing policy processes and ascertain the extent to which health institutions give serious consideration to climate change impacts on health vulnerabilities of Māori (Indigenous people). Speaking to tāngata whenua (Indigenous Māori), rangatahi (Indigenous Māori youth) and District Health Board (DHB) employees it was clear that processes were ad hoc and problematically silenced consistent Māori input. Research participants expressed their experiences of, and aspirations for, dealing with climate change. Their voices were not evident in DHB policy processes. The deficit in existing policy process shows a lack of preparedness in the face of climate change. Despite clear resilience and adaptation strategies, structural change is needed to address identified disadvantages. Through a co-designed a policy framework (“Haumanu Hauora”) we guide policy formation to mitigate climate change risk to Māori (and others). Central to the revised policy framework is the introduction of a commissioning, refining and monitoring stage. Alongside the policy framework intervention points provide guidance to the newly developed health institutions. Five intervention points reflect the substantial work needed to develop Māori responsive policy in anticipation of climate change impacts. Above all, we believe that strengthening health institution responsiveness to Māori health needs is essential.
Modelling of corrosion rate in the drinking water distribution network using Design Expert 13 software
Authors: Kumar Saurabh , Singh Reena , Maurya Nityanand Singh 
Published: September 2022

Abstract
This study focused on the modelling of corrosion rate of the water distribution network of Patna, (Bihar), India using Design Expert 13 software. A total of nine variables, including pH, temperature, total dissolved solid (TDS), alkalinity, calcium hardness, chloride, sulphate, dissolved oxygen (DO), and time, were considered for modelling. The physicochemical parameters were determined through regular monitoring of water samples. The corrosion rate was determined by direct monitoring of water distribution pipes using adjustments of seven GI coupons for 45, 90, 135, 180, 225, 270, and 315 days. Modelling was performed using the low level and high-level experimental range for pH, temperature, TDS, alkalinity, calcium hardness, chloride, sulphate, DO, and time were 7.28, 23, 430, 115, 24, 18, 10.94, 3.5, 0 and 7.86, 28, 704, 284, 180, 98, 38.7, 6.8, and 315, respectively. Using the Box-Behnken design (BBD), 160 runs were conducted, including ten replicates at the central point of each block. The results of ANOVA indicate that values of R2, adjusted R2, and predicted R2 are 0.9714, 0.9507, and 0.8941, respectively. The value of R2 (0.9714) was close to 1, which indicates a good fit. The adequate precision was found to be 30.8442, indicating a good signal. A coefficient of variance discusses reproducibility, and in this case, it was 9.90%. On the basis of the ANOVA result, the quadratic model is well-fit and can be accepted as a suitable model. A total of seven parameters such as chloride, sulphate, hardness, alkalinity, pH, calcium, and hardness were used for the design of the experimental corrosion rate (CR). These individual CR vs. synthetic aqueous solutions were used to validate the interaction of the response surface. It was found that the trend of individual corrosion rates in synthetic aqueous solutions and the interaction of composite variables with corrosion rates in a quadratic model of response surfaces were clearly correlated.
Contamination status of paralytic shellfish toxins in shellfish from Southeastern China in 2017–2021
Authors: Zheng Renjin , Yang Yafang , Zhang Wenting , Hua Yongyou 
Published: September 2022

Abstract
A total of 2,355 shellfish samples were analyzed by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) to study the toxin profiles of the 10 paralytic shellfish toxins (PSTs) collected from the southeast coast of China from 2017 to 2021. From 2355 shellfish samples (10.91%), 257 were detected, with the highest value in samples of Perna viridis. Among the six source areas in China, the samples from Fujian recorded the highest detected rate (15.28%). PSTs were found in Fuzhou (FZ), Ningde (ND), Quanzhou (QZ), Putian (PT), Zhangzhou (ZZ), and Xiamen (XM), with QZ and FZ having the highest and lowest detection rates of 15.28% and 4.23%, respectively. Saxitoxin (STX), neosaxitoxin (neoSTX), gonyautoxin (GTX1, GTX2, GTX3, GTX4), N-sulfocarbamoyl toxin (GTX5), and decarbamoyl toxin (dcSTX, dcGTX2, dcGTX3) were detected, and GTX5 and dcGTX2 were dominant. In addition, the samples containing PSTs were mostly concentrated in May to August and occasionally detected in December. The findings of this study will serve as a solid foundation for detecting marine contaminants and preserving seafood consumers’ health.
A qualitative exploration of the experiences of peer leaders in an intervention to improve diabetes medication adherence in African Americans
Authors: Tarfa Adati , Nordin Jenna , Mott Mattigan , Maurer Martha , Shiyanbola Olayinka 
Published: September 2022

Abstract
Background: African Americans chronically managing their diabetes benefit from receiving support from peers with shared experiences. Peer support is known to improve the well-being of individuals receiving support, however, there is limited literature on the experiences of those providing the support. The Peers Supporting Health Literacy, Self-efficacy, Self-Advocacy, and Adherence (Peers LEAD) program pairs Peer Ambassadors who are adherent to their diabetes medication, with Peer Buddies who need support with their medication adherence. Peer Ambassadors engage with Peer Buddies as they receive diabetes information, develop the skills and motivation to address identified psychosocial/sociocultural issues to enhance their diabetes medication adherence. This study qualitatively explores the experiences of African Americans who provided peer support in the Peers LEAD medication adherence intervention.
Methods: Two focus groups were conducted with twelve Peer Ambassadors to explore their experiences of providing peer support in the Peers LEAD medication adherence intervention. Qualitative content analysis was conducted using an inductive open coding approach.
Results: Emergent themes provided insight into Peer Ambassador’ rationale for providing peer support and the benefits and challenges they experienced in their roles. Themes regarding their rationale included: their desire to receive support for their diabetes self-management as well as to contribute to their communities in reducing the stigma associated with diabetes. The perceived benefits they gained centered on creating interpersonal connections, experiencing personal growth as they adapted to their roles, and experiencing opportunities to contribute to an intervention regardless of professional training. Peer Ambassadors reflected on the challenges which included difficulties on coming to terms with their role as Peer Ambassadors, seeing African Americans experience complications associated with diabetes, and navigating supporting Peer Buddies who are also burdened with the challenges their family members are experiencing with managing their diabetes.
Conclusions: This study provides unique insight to what motivates individuals to provide peer support and what they gain from these experiences despite challenges. Understanding the experiences of peers participating in such interventions may help inform the structure and content of programs that use peer support to focus on the benefits of and the motivation for participating in the program.
Multi-omics assisted breeding for biotic stress resistance in soybean
Authors: Bisht Ashita , Saini Dinesh Kumar , Kaur Baljeet , Batra Ritu , Kaur Sandeep , Kaur Ishveen , Jindal Suruchi , Malik Palvi , Sandhu Pawanjit Kaur , Kaur Amandeep , Gill Balwinder Singh , Wani Shabir Hussain , Kaur Balwinder , Mir Reyazul Rouf , Sandhu Karansher Singh , Siddique Kadambot H.M 
Published: September 2022

Abstract
Biotic stress is a critical factor limiting soybean growth and development. Soybean responses to biotic stresses such as insects, nematodes, and fungal, bacterial, and viral pathogens are governed by complex regulatory and defense mechanisms. Next-generation sequencing has availed research techniques and strategies in genomics and postgenomics. This review summarizes the available information on marker resources, quantitative trait loci, and marker trait associations involved in regulating biotic stress responses in soybean. We discuss the differential expression of related genes and proteins reported in different transcriptomics and proteomics studies and the role of signaling pathways and metabolites reported in metabolomic studies. Recent advances in omics technologies offer opportunities to reshape and improve biotic stress resistance in soybean by altering gene regulation and/or other regulatory networks. We recommend using ‘integrated omics’ to understand how soybean responds to different biotic stresses. We discuss the potential challenges of integrating multiomics for functional analysis of genes and their regulatory networks and the development of biotic stress-resistant cultivars. This review will help direct soybean breeding programs to develop resistance against different biotic stresses.
Application of IMMF-IHHT algorithm to suppressing random interference of geomagnetic sensors
Authors: zhang pingan , gao min , wang wei , wang yi , xujun su 
Published: September 2022

Abstract
Aiming at the problem that the geomagnetic sensor is vulnerable to external interference in the navigation process, this paper analyzes the frequency distribution range of geomagnetic signal and the noise characteristics in geomagnetic signal, and proposes an improved morphological filtering and Hilbert-Huang transform (IMMF-IHHT) algorithm to extract and recognize the features of geomagnetic measurement signal. To avoid frequency aliasing and distortion caused by empirical mode decomposition, an improved morphological filtering algorithm based on mean constraint is used to preprocess the measured signal. The Hilbert spectrum of the decomposed signal is solved, the signal components are discriminated by the similarity criterion, and the signal components in line with the frequency range of the geomagnetic signal are extracted and processed to reconstruct the geomagnetic measurement signal. Simulation and experiments show that the Signal-to-Noise Ratio (SNR) and Root Mean Square Error (RMSE) of IMMF-IHHT combination algorithm are better than MF-HHT combination algorithm and IHHT algorithm. This algorithm has good signal feature extraction and recognition ability.
Effects of Branched-Chain Amino Acids on Patients Undergoing Hepatic Intervention: A Meta-Analysis of Randomized Controlled Trials
Authors: Hsu Yan-Mei , Kuan Hui-Chung , Chen Yu-An , Chiu Ching-Wen , Chen Po-Cheng , Tam Ka-Wai 
Published: September 2022

Abstract
BACKGROUND: The benefits of branched-chain amino acid (BCAA) administration after hepatic intervention in patients with liver diseases remains unclear. We conducted a systematic review and meta-analysis to evaluate the effects of BCAA on patients undergoing hepatectomy, trans-arterial embolization, radiofrequency ablation.
METHODS: Relevant randomized controlled trials (RCTs) were obtained from PubMed, EMBASE, and Cochrane Library databases. A meta-analysis was performed to calculate the pooled effect size by using random-effects models. The primary outcomes were survival, hospital stay, nutrition status, and biochemistry profile. The secondary outcomes were the complication rate of liver treatment and adverse effect of BCAA supplementation.
RESULTS: In total, 11 RCTs involving 750 patients were included. Our meta-analysis showed no significant difference in the rates of tumorrecurrence and overall survival between the BCAA and control groups. However, the pooled estimate showed that BCAA supplementation in patients undergoing hepatic intervention significantly increased serum albumin (mean difference [MD]: 0.11 g/dL, 95% confidence interval [CI]: 0.02–0.20) at 6 months and cholinesterase level (MD: 50.00 U/L, 95% CI: 21.08–78.92) at 12 months, increased body weight (MD: 3.29 kg, 95% CI: 1.07–5.50) at 12 months, and reduced ascites incidence (risk ratio: 0.39, 95% CI: 0.21–0.71) compared with the control group. Additionally, BCAA administration shortened the hospital stay length (MD: −2.36 days, 95% CI: −4.78 to 0.07) compared with the control group.
CONCLUSION: BCAA supplementation significantly reduced postintervention complication and hospitalization duration and increased body weight. Thus, BCAA supplementation may benefit patients undergoing liver intervention.