bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated app-based augmented reality cognitive behavioral therapy for spider phobia: Study protocol for a randomized controlled trial
Authors: Toffolo Marieke B. J. , Fehribach Jamie R. , van Klaveren Chris P. B. J. , Cornelisz Ilja , van Straten Annemieke , van Gelder Jean-Louis , Donker Tara 
Published: July 2022

Background
Fear of spiders, or Arachnophobia, is one of the most common specific phobias. The gold standard treatment, in vivo exposure therapy, is effective, but comes with significant limitations, including restricted availability, high costs, and high refusal rates. Novel technologies, such as augmented reality, may help to overcome these limitations and make Exposure Therapy more accessible by using mobile devices.

Objective
This study will use a Randomized Controlled Trial design to investigate whether ZeroPhobia: Arachnophobia, a 6-week Augmented Reality Exposure Therapy smartphone self-help application, can effectively reduce spider phobia symptoms. Additionally, we will examine user-friendliness of the application and the effect of usage intensity and presence on treatment outcome.

Methods
This study is registered in the Netherlands Trial Registry under NL70238.029.19 (Trial NL9221). Ethical approval was received on October 11, 2019. One-hundred-twelve participants (age 18–64, score ≥ 59) on the Fear of Spiders Questionnaire [FSQ] will be recruited from the general Dutch population and randomly assigned to a treatment or waitlist control group. The ZeroPhobia application can be accessed on users’ smartphone. Baseline, post-test (i.e., at six weeks), 3- and 12-month follow-up assessments will be done, each including the Fear of Spiders Questionnaire as the main outcome measure as well as additional measures of anxiety, depression, user-friendliness, and presence as secondary measures and covariates.

Results
The study was funded on September 25, 2018. Data collection started in September 2021 and the study is expected to run until September 2022.

Conclusions
Our study will improve our understanding of the efficacy and feasibility of providing Exposure Therapy for spider phobia using an Augmented Reality self-help application, with the intention of making mental health care more accessible.
Human papillomavirus vaccination uptake and its associated factors among adolescent school girls in Ambo town, Oromia region, Ethiopia, 2020
Authors: Beyen Mulugeta W/mariam , Bulto Gizachew Abdissa , Chaka Eshetu Ejeta , Debelo Bikila Tefera , Roga Ephrem Yohannes , Wakgari Negash , Danusa Kababa Temesgen , Fekene Daniel Belema 
Published: July 2022

Background
The Human Papillomavirus (HPV) vaccine has offered a great promise to reduce the cervical cancer burden; its utilization (uptake) however has been lagging. However, the levels and factors associated with the uptake of the vaccine have not been well investigated, especially in the local context.

Objective
To assess the uptake of human papillomavirus vaccination and its associated factors among adolescent school girls in ambo town, Oromia, Ethiopia, 2020.

Methods
An institution-based cross-sectional quantitative study design supplemented with the qualitative inquiry was employed to assess Human Papillomavirus vaccination uptake and its associated factors among 422 adolescent school girls in Ambo town, central Ethiopia from December 1–30, 2020. The collected data were coded, entered, and cleaned by using Epi info 7.2.3 and exported to SPSS version 25 for analysis. Descriptive statistics were used to compute summary statistics and proportions. Both bivariate and multivariable logistic regression was employed to identify factors associated with HPV vaccine uptake. Adjusted odds ratio and 95% confidence interval were used for the strength and directions of association. A P-value of < 0.05 was used to declare statistical significance. Qualitative findings have been analyzed with manual thematic analysis.

Result
The proportion of HPV vaccination uptake among school girls in this study was 44.4%. Hearing about HPV vaccine [AOR = 2.50, 95%CI: (1.045–5.959)], availability of awareness creation [AOR = 2.53, 95%CI: (1.507–4.258)], and favorable attitude [AOR = 2.049, 95%CI: (1.153–3.64)] were the key identified factors associated with vaccination uptake. In addition, poor perception, fear of side effects, and misunderstanding were among the major factors identified by qualitative findings.

Conclusion
There was low uptake of HPV vaccination among the school Adolescents in the study area. Availability of awareness creation programs, favorable attitude towards HPV vaccine, and hearing about HPV vaccine was significantly associated with the uptake of the HPV vaccination. Therefore, awareness creation and behavior change education are mandatory to scale up the vaccination.
Identification of the shared gene signatures and pathways between polycystic ovary syndrome and endometrial cancer: An omics data based combined approach
Authors: Miao Chenyun , Chen Yun , Fang Xiaojie , Zhao Ying , Wang Ruye , Zhang Qin 
Published: July 2022

ObjectivePolycystic ovary syndrome (PCOS) is a common endocrine disorder with high incidence. Recently it has been implicated as a significant risk factor for endometrial cancer (EC). Our study aims to detect shared gene signatures and biological mechanism between PCOS and EC by bioinformatics analysis.MethodsBioinformatics analysis based on GEO database consisted of data integration, network construction and functional enrichment analysis was applied. In addition, the pharmacological methodology and molecular docking was also performed.ResultsTotally 10 hub common genes, MRPL16, MRPL22, MRPS11, RPL26L1, ESR1, JUN, UBE2I, MRPL17, RPL37A, GTF2H3, were considered as shared gene signatures for EC and PCOS. The GO and KEGG pathway analysis of these hub genes showed that “mitochondrial translational elongation”, “ribosomal subunit”, “structural constituent of ribosome” and “ribosome” were highly correlated. Besides, associated transcription factors (TFs) and miRNAs network were constructed. We identified candidate drug molecules including fenofibrate, cinnarizine, propanil, fenthion, clindamycin, chloramphenicol, demeclocycline, hydrochloride, azacitidine, chrysene and artenimol according to these hub genes. Molecular docking analysis verified a good binding interaction of fenofibrate against available targets (JUN, ESR1, UBE2I).ConclusionGene signatures and regulatory biological pathways were identified through bioinformatics analysis. Moreover, the molecular mechanisms of these signatures were explored and potential drug molecules associated with PCOS and EC were screened out.
The existence of ground state solutions for semi-linear degenerate Schrödinger equations with steep potential well
Authors: Ran Ling , Chen Shang-Jie , Li Lin 
Published: July 2022

In this article, we study the following degenerated Schrödinger equations:

{

−

Δ

γ

u
+
λ
V
(
x
)
u
=
f
(
x
,
u
)

in

R

N

,

u
∈

E

λ

,

where
λ
>
0
is a parameter,

Δ

γ

is a degenerate elliptic operator, the potential
V
(
x
)
has a potential well with bottom and the nonlinearity
f
(
x
,
u
)
is either super-linear or sub-linear at infinity in
u
. The existence of ground state solution be obtained by using the variational methods.
Penza Regional Organization of the "Znanie" Society in the 1960s-1980s: Lecturers, Primary Organizations, Lecture Propaganda
Authors: Vaserov I.D. 
Published: July 2022

The article deals with the quantitative and "qualitative" composition of the lecturers' staff of Penza regional organization of "Znanie" Society (by party affiliation — predominance of members and candidates for membership in the CPSU, Komsomol; by profession — most teachers, lecturers, Soviet-party workers, medical workers, etc.).
We study the peculiarities of membership in the Society of its "foremost group" — scientists, teachers of regional institutes; in particular, the weak participation of representatives of technical departments, simultaneous "workload" in the work not only of the Society, but also of lecture groups, Marxism-Leninism University, etc.; we identify their activity indicators in the lecture work of the organization, which, as a rule, fell behind the republican ones.
The tasks, quantitative dynamics, and composition of the Society's primary organizations in the region are characterized. Methodical sections, sections on branches of knowledge and scientific-methodical councils were directly engaged in educational and methodical support of lecture work and its organization, control over the content of lectures through reviewing, interaction with the Soviet-party and public structures.
The educational function of the Society was carried out mainly through lecture propaganda. The number of lectures read by the members of the regional organization was increasing; the majority of them were social and political.
The Concept of Ethnoculture in Ethnographic Views of N.M. Yadrintsev (on the 180th Birthday of the Public Figure)
Authors: Golovinov A.V. , Golovinova Yu.V. 
Published: July 2022

Within the framework of this publication, an attempt has been made to reconstruct the concept of ethnoculture in the ethnographic concepts of N.M. Yadrintseva. The article emphasizes that ethnocultural ideas are not always explicated in the rich journalistic and ethnographic heritage of the founder of Siberian regionalism. The authors proceed from the fact that the theoretical constructions of the founder of Siberian regionalism were the fruitful result of his practical immersion in the ontology of the indigenous that is, the alien population of Siberia. It is noted that the term "ethnoculture" itself was not used in the works of Nikolai Mikhailovich, as it was atypical for science in the second half of the 19th century. Nevertheless, it seems possible, based on published sources containing statistical, archaeological, geographical and, mainly, ethnographic developments of the ideologist of the regional program, to show the essence and content of ethnoculture in the ethnographic research of a publicist.
The article establishes that ethnic culture is an amazing combination of traditions, attitude, and way of life, occupation, which are due to ethnic, climatic and geographical conditions.
Developing the Issue on the General Population Census in the Russian Empire in the 19th — Early 20th Century: A Historiographical Review
Authors: Bryukhanova E.A. , Belorukov M.V. , Nurmukhan E.T. 
Published: July 2022

The development of Russian and world statistics in the 19th century is of considerable interest for representatives of different sciences, such as historians, statisticians, demographers, etc. The attention of researchers to this period is due to incredibly rapid development of the theory, methodology and practice of statistical surveys, formation of statistics as a branch of public administration. Special attention was paid to the development of scientific methods of population accounting, in particular censuses, which was reflected in the publications of that time. The study of works reflecting the development of ideas about the all-social population accounting, in particular the formation of theses about "scientific", "correct" population censuses and the accumulation of experience in their conduct, seems relevant.
The article presents a historiographical review of publications of different periods, which allows to identify the possible stages of development of the idea of the general population census and its implementation in the Russian Empire. The main methods of research are bibliographical and historiographical analysis, the sources for which are works in the field of history of statistics, demography, the census itself of the pre-revolutionary, Soviet and modern periods.
Делается вывод о том, что генезис идеи научной переписи в России происходил в контексте развития зарубежной и отечественной статистики, а проведение Первой всеобщей переписи населения на всей территории Российской империи стало событием, оказавшим значительное влияние на дальнейшую историю науки.
RECYCLING OF WET-STRENGTH TISSUE PAPER. PART 2. BASIC PROPERTIES OF SECONDARY FIBERS
Authors: Penkin Anton Anatolʹyevich , Kazakov Yakov Vladimirovich 
Published: July 2022

The present investigation focuses on morphological characteristics, tensile and optical properties of secondary fibers obtained in various conditions of batch low-consistency repulping process for wet-strength tissue paper with 100% of bleached softwood kraft pulp. It was found that length-weighted fiber length and fiber width values as well as fiber length and fiber width distributions remained almost unchanged regardless of the repulping time and the presence of persulfates. The shortened repulping cycle due to the use of persulfates lead to an increase in the shape factor from 83.0% to 84.1–84.4%, decrease in the number of fiber kinks from 0.84 to 0.72–0.74 and an increase in zero-span tensile strength of recycled handsheets by 10–12%. At the same time, the shortened repulping cycle resulted in increase in the coarseness of secondary fibers from 190 mg/m to 230–235 mg/m leading to a slight increase in the bulk of the paper and a decrease in its internal bond strength by an average of 8%. The use of persulfates during wet-strength tissue paper repulping improves the color of recycled handsheets and its brightness by up to 3%.
OPTIMIZATION OF BIRD CHERRY OIL SUPERCRITICAL FLUID EXTRACTION PROCESS
Authors: Skrebets Tatʹyana Eduardovna , Ivakhnov Artem Dmitriyevich , Mamatmurodov Hurshed Begmahmudovich 
Published: July 2022

Cherry cake berries, which is a waste of liquor production, contain biologically active substances, including lipids, which are not extracted by ethanol in the main production. Supercritical carbon dioxide is a good extractant for such compounds. By method of full factor experiment using rotatable uniform-plan of the second order, process of optimization of extraction of cherry oil from processed berries by method of supercritical fluid extraction with carbon dioxide was carried out. During planning, the pressure of 250 atm, temperature of 60 °C, hydraulic module 25 are selected as the main levels. To increase the accuracy of optimization, additional coefficients are sequentially included based on the Fisher test not increasing. Analysis of the regression equation made it possible to establish optimal process parameters: temperature 70 °C, pressure 350 atm, hydraulic module 33 at oil yield 1.4% (extraction degree 85%). The relative model error was 1%. Acid, iodine, ether numbers, saponification number, as well as organoleptic indices are determined for the obtained product. The obtained product is enriched with triacylglycerides, free fatty acids and low-molecular organic acids and contains a small amount of unsaturated higher carboxylic acids compared to oil isolated by extraction in a Soxlet apparatus with hexane.
Encuesta de conocimientos, actitudes y prácticas sobre dietas milagro en población española: estudio transversal “DiMilagro”
Authors: Baladia Eduard , Moñino Manuel , Martínez-Rodríguez Rodrigo , Moreno Ignacio , Miserachs Martina , Picazo Oscar , Marcos Alexandra , Morte Víctor , Russolillo Giuseppe 
Published: July 2022

Introducción: La aparición de dietas milagro podría deberse a la dificultad de la población para modificar sus estilos de vida y conseguir la adherencia a intervenciones terapéuticas. El objetivo de este trabajo fue evaluar los conocimientos, actitudes y prácticas sobre dietas milagro en un panel de consumidores de características socio demográficas similares a la población española.
Material y métodos: Estudio transversal con encuesta online de conocimientos, actitudes y prácticas no validada y elaborada según guías de FAO, en muestra de ambos sexos de 18 a 65 años.
Resultados: Hubo 2.604 encuestas válidas (50% mujeres). La mayoría (57,9%) declaró conocer alguna característica de las dietas milagro y supo identificarlas (65,8%). El 90% cree que no funcionan y que sus efectos son principalmente negativos (82,6%). 487 personas (18,7%) declararon haber seguido una o varias dietas milagro, durante 15 días y más de 6 meses, tomado algún producto asociado (56%) que adquirieron en herboristerías (52%) y farmacias (30%), y creyeron percibir (57%, n=277) alguno de los efectos prometidos, aunque sólo a corto plazo, y el 33% creyó percibir algún efecto adverso de carácter leve. El 73,7% del total de la muestra declaró que las dietas milagro son un problema y el 78,6% que son peligrosas. El 82,1% no indicó sentirse vulnerable por la adopción de una dieta milagro.
Conclusiones: El nivel de conocimiento sobre las dietas milagro en la población del estudio es medio, la mayoría las percibe como un problema, pero no se siente vulnerable ni con intención de seguir una dieta milagro. Sin embargo, el 22% de la muestra siguió algún tipo de dieta milagro, aunque solo el 18,7% lo reconoce. Es necesario nuevas investigaciones que exploren, en mayor profundidad, cómo el nivel conocimiento y actitud de la población frente a las dietas milagro se relaciona con la práctica.
Cáscaras de frutas y vegetales como ingrediente en pan: aporte nutricional, saciedad y preferencia sensorial
Authors: Quitral Vilma , Sepúlveda Marcela , Figueroa Dominique , Saa Viviana , Flores Marcos 
Published: July 2022

Introducción: Se entiende por “desperdicio” de alimentos a las pérdidas derivadas de la decisión de desechar aquellos que todavía tienen valor, o a partes de ellos, y se asocia principalmente con ventas minoristas y consumidores. Dentro de los “desperdicios” se encuentran las cáscaras de vegetales, que se pueden rescatar e incluir como ingredientes en alimentos procesados.
Metodología: Se elaboraron muestras de pan de molde cuya formulación base fue harina, aceite, levadura, sal, azúcar y agua. Se reemplazó 10% de la harina de trigo por harinas de cáscaras de manzana, zanahoria y zapallo (P2, P3 y P4 respectivamente). Las cáscaras de los vegetales se lavaron exhaustivamente, se deshidrataron a 60° por 12 horas y se molieron hasta obtener un polvo fino. Se elaboraron muestras de pan amasando la mezcla de ingredientes por 15 minutos, se dejó fermentar y luego se hornearon a 180°C por 50 minutos. Se determinó pérdida por cocción, composición nutricional, azúcares totales y aporte calórico. Las muestras de pan fueron evaluadas por 15 sujetos para conocer el cociente de saciedad y por 60 sujetos para establecer la preferencia sensorial.
Resultados: La incorporación de harina cáscaras de vegetales no modificó, el contenido de proteínas, grasa total ni hidratos de carbono disponibles. La muestra P2 presentó el contenido de azúcares totales significativamente mayor (p<0,05), la fibra dietética fue mayor en todas las muestras con cáscaras de vegetales respecto a la muestra control (P1), y el contenido de energía disminuyó significativamente (p<0,05) en las muestras de pan con harina de cáscaras de vegetales.
El coeficiente de saciedad fue mayor en la muestra P2 y fue menor en P1, sin diferencias significativas. La mayor preferencia sensorial fue para P3 y P2.
Conclusión: La muestra de pan elaborada con cáscara de manzana al 10% resultó la mejor alternativa, con menor aporte calórico, mayor aporte de fibra dietética produjo mayor cociente de saciedad y mayor preferencia sensorial.
Selection and functional identification of Dof genes expressed in response to nitrogen in Populus simonii × Populus nigra
Authors: Wang Shenmeng , Wang Ruoning , Yang Chengjun 
Published: July 2022

Abstract
In plants, Dof transcription factors are involved in regulating the expression of a series of genes related to N uptake and utilization. Therefore, the present study investigated how DNA-binding with one finger (Dof) genes are expressed in response to nitrogen (N) form and concentration to clarify the role of Dof genes and their functions in promoting N assimilation and utilization in poplar. The basic characteristics and expression patterns of Dof genes in poplar were analyzed by the use of bioinformatics methods. Dof genes expressed in response to N were screened, after which the related genes were cloned and transformed into Arabidopsis thaliana; the physiological indexes and the expression of related genes were subsequently determined. The function of Dof genes was then verified in Arabidopsis thaliana plants grown in the presence of different N forms and concentrations. Forty-four Dof genes were identified, most of which were expressed in the roots and young leaves, and some of the Dof genes were expressed under ammonia- and nitrate-N treatments. Three genes related to N induction were cloned, their proteins were found to localize in the nucleus, and PnDof30 was successfully transformed into Arabidopsis thaliana for functional verification. On comparing Arabidopsis thaliana with WT Arabidopsis thaliana plants, Arabidopsis thaliana plants overexpressing the Dof gene grew better under low N levels; the contents of soluble proteins and chlorophyll significantly increased, while the soluble sugar content significantly decreased. The expressions of several AMT, NRT, and GS genes were upregulated, while the expressions of several others were downregulated, and the expression of PEPC and PK genes significantly increased. In addition, the activity of PEPC, PK, GS, and NR enzymes significantly increased. The results showed that overexpression of PnDof30 significantly increased the level of carbon and N metabolism and improved the growth of transgenic Arabidopsis thaliana plants under low-N conditions. The study revealed the biological significance of poplar Dof transcription factors in N response and regulation of related downstream gene expression and provided some meaningful clues to explain the huge difference between poplar and Arabidopsis thaliana transformed by exogenous Dof gene, which could promote the comprehensive understanding of the molecular mechanism of efficient N uptake and utilization in trees.
Measurement of anti SARS-CoV-2 RBD IgG in saliva: validation of a highly sensitive assay and effects of the sampling collection method and correction by protein
Authors: Martínez-Subiela Silvia , Franco-Martínez Lorena , Rubio Camila P. , Muñoz-Prieto Alberto , Torres-Cantero Alberto , Tecles Fernando , Sánchez-Resalt Cristina , Cerón José J. , Tvarijonaviciute Asta 
Published: July 2022

Abstract

Objectives
To develop and evaluate a new highly sensitive assay to detect IgG anti-SARS-CoV-2 RBD in saliva samples.

Methods
A two-step sandwich type immunoassay based on the amplified luminescent proximity homogeneous technology was developed and an analytical validation was performed. As a part of this validation, the influence of factors, such as different sampling conditions (stimulated saliva and passive drool) and the correction of values by total protein content, in the ability of saliva to detect increases in antibodies after an immune stimulus and be an alternative to serum, was evaluated. For this purpose, paired samples of saliva and serum at different times after vaccination were used.

Results
Saliva concentrations were lower than serum, but both fluids showed similar kinetics, with higher correlations when saliva was obtained by passive flow and the results were not corrected by protein.

Conclusions
The developed method showed a good analytical performance and can properly measure antibody concentrations in saliva of vaccinated individuals. However, saliva could have a lower sensitivity compared to serum at initial stages of the immune response and also when the antibody response decreased after a stimulus.