bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of political connections: evidence from China's anti-corruption campaign
Authors: Alonso Marta , Palma Nuno , Simon-Yarza Beatriz 
Published: February 2022

AbstractWe study the value of the political connections of directors on Chinese boards. We build a new dataset that measures connections of directors to members of the Politburo via past school ties, and find that private firms with politically connected directors in the boardroom get on average about 16% higher subsidies over sales per firm (7 million yuan). Connected state-owned enterprises (SOEs) access debt at 11% cheaper cost, which translates into average savings of close to 32 million yuan per firm in lower interest payments. We find that the value of the political connections persisted after the anti-corruption campaign (ACC) of 2012. It became weaker for the cost of debt in SOEs, but stronger for subsidies to private firms. We argue that the value of connections in the private sector increased after the ACC because they became a less risky alternative to corruption. We also show that connected firms do not perform better.
Metasurface-based electromagnetic structure for electromagnetic absorption and radiation application
Authors: Rahman Saeed Ur , Deng Hai , Cao Qunsheng , Wang Yi , Khan Muhammad Irshad , Khan Zakir , Sajjad Muhammad , Khalil Hisham 
Published: February 2022

AbstractIn this paper, a metasurface (MS)-based multi-functional electromagnetic (EM) structure is proposed to realize its two different applications, namely absorption and radiation. The proposed structure is based on periodic arrays of disk-shaped metallic patches and split rings with four embedded lumped resistors. The metallic vias are inserted from top to bottom to connect the disk-shaped patches with a feeding network designed on the bottom layer where two p-i-n switches are embedded in the feeding network to alter the different functions of the proposed structure. For free space incident plan wave, the designed structure works as an absorber when the p-i-n switches are switched OFF. The absorber operates over a frequency band from 6.2 GHz to 8.2 GHz and unchanged over an incident angle from 0° to 30° for both TE and TM polarized incident waves. The same structure also works as a low scattering and high gain radiator when the p-i-n switches are turned ON and radiate within absorbing frequency band, i.e. from 7.5 to 8.0 GHz. The designed structure is fabricated and experimentally verified for EM absorption and radiation applications.
Generalized Effective Biot Theory and Seismic Wave Propagation in Anisotropic, Poroviscoelastic Media
Authors: Huang Xingguo , Greenhalgh Stewart , Han Li , Liu Xu 
Published: February 2022

AbstractThe interior of the Earth is quite complex due to the actual geometrical structure and the presence of complex rheological materials, including viscoelastic rocks, porous sediments and the presence of anisotropy. Seismic wavefield forward modeling in such media forms the basis of most wave equation‐based methods for investigating the structure of the Earth and processing and imaging of seismic data, e.g., seismic full waveform inversion. Numerical modeling using Biot's equations that describe the physics of poroelasticity provides a useful framework to investigate wave attenuation and dispersion. Poroelasticity describes the interaction between the deformation of an elastic porous solid and the fluid flow in the porous structure. We present a time‐domain finite‐difference method for seismic wavefield modeling, taking into account both attenuation and anisotropy of poroviscoelastic Earth structure. The mathematical formulations and modeling methods are based on (a) the linear Biot's poroelastic theory and double porosity models in anisotropic media and (b) a relaxation function that uses the generalized standard linear solid model with anisotropic τ parameter for magnitude of attenuation and nearly constant Q model. Using a modified relaxation function that is suggested to describe the anisotropy attenuation, we develop a generalized anisotropic Biot model in the anisotropic, viscoelastic media. In addition to the anisotropic poroelasticity based on Biot theory, we implement the generalized anisotropic Biot model with complex moduli for an effective Biot's model in which the attenuative anisotropic viscoelastic model with the generalized standard linear solid model is used to approximate the attenuation factor function. The method generalizes the linear poroviscoelastic model based on effective Biot theory for seismic wave modeling to the attenuative, anisotropic case. In the anisotropic, poroviscoelastic model, we represent the bulk modulus and shear modulus of the solid frame by the modified relaxation function. We present time‐domain finite‐difference modeling for seismic wavefields in anisotropic, viscoelastic porous media including transversely isotropic media with a vertical, tilted or horizontal symmetry axis (VTI, TTI, and HTI). We also consider the extension of the two new models to nearly constant Q viscoelastic anisotropy.
Assessing the Influence of Input Magnetic Maps on Global Modeling of the Solar Wind and CME‐Driven Shock in the 2013 April 11 Event
Authors: Jin Meng , Nitta Nariaki V. , Cohen Christina M. S. 
Published: February 2022

AbstractIn the past decade, significant efforts have been made in developing physics‐based solar wind and coronal mass ejection (CME) models, which have been or are being transferred to national centers (e.g., SWPC, Community Coordinated Modeling Center) to enable space weather predictive capability. However, the input data coverage for space weather forecasting is extremely limited. One major limitation is the solar magnetic field measurements, which are used to specify the inner boundary conditions of the global magnetohydrodynamic (MHD) models. In this study, using the Alfvén wave solar model, we quantitatively assess the influence of the magnetic field map input (synoptic/diachronic vs. synchronic magnetic maps) on the global modeling of the solar wind and the CME‐driven shock in the 11 April 2013 solar energetic particle event. Our study shows that due to the inhomogeneous background solar wind and dynamical evolution of the CME, the CME‐driven shock parameters change significantly both spatially and temporally as the CME propagates through the heliosphere. The input magnetic map has a great impact on the shock connectivity and shock properties in the global MHD simulation. Therefore this study illustrates the importance of taking into account the model uncertainty due to the imperfect magnetic field measurements when using the model to provide space weather predictions.
The enhanced genomic 6 mA metabolism contributes to the proliferation and migration of TSCC cells
Authors: Xi Lei , Yang Ying , Xu Ying , Zhang Fangming , Li Jinghui , Liu Xiyang , Zhang Zhenxi , Du Quan 
Published: February 2022

AbstractIn contrast to the well-established genomic 5-methylcytosine (5mC), the existence of N6-methyladenine (6 mA) in eukaryotic genomes was discovered only recently. Initial studies found that it was actively regulated in cancer cells, suggesting its involvement in the process of carcinogenesis. However, the contribution of 6 mA in tongue squamous cell carcinoma (TSCC) still remains uncharacterized. In this study, a pan-cancer type analysis was first performed, which revealed enhanced 6 mA metabolism in diverse cancer types. The study was then focused on the regulation of 6 mA metabolism, as well as its effects on TSCC cells. To these aspects, genome 6 mA level was found greatly increased in TSCC tissues and cultured cells. By knocking down 6 mA methylases N6AMT1 and METTL4, the level of genomic 6 mA was decreased in TSCC cells. This led to suppressed colony formation and cell migration. By contrast, knockdown of 6 mA demethylase ALKBH1 resulted in an increased 6 mA level, enhanced colony formation, and cell migration. Further study suggested that regulation of the NF-κB pathway might contribute to the enhanced migration of TSCC cells. Therefore, in the case of TSCC, we have shown that genomic 6 mA modification is involved in the proliferation and migration of cancer cells.
Early vascular toxicity after pediatric allogeneic hematopoietic stem cell transplantation
Authors: Leimi Lilli , Jahnukainen Kirsi , Olkinuora Helena , Meri Seppo , Vettenranta Kim 
Published: February 2022

AbstractTreatment-related mortality and morbidity remain a challenge in hematopoietic stem cell transplantation (HSCT). In this retrospective, single-center study, we analyzed endothelial damage as a potential, common denominator and mechanism for the adverse effects. We evaluated the prevalence of key vascular complications and graft-versus-host disease among 122 pediatric patients with an allogeneic HSCT between 2001 and 2013. The spectrum and frequency of acute adverse events emerging ≤100 days post transplant were graded according to the CTCAE 4.03 and analyzed. We identified a total of 19/122 (15.6%) patients with vascular complications, fulfilling the criteria of capillary leak syndrome, veno-occlusive disease/sinusoidal obstruction syndrome or thrombotic microangiopathy. The patients had a poorer overall survival (77% versus 26%, p < 0.001). Nearly one half (56/122, 45.9%) had at least one, severe (grade 3 or 4) adverse event. Patients with vascular complications had more often edema/effusions (p = 0.023), thrombocytopenia (p = 0.001), gastrointestinal bleeding (p < 0.001), acute kidney injury (p < 0.001), ascites (p < 0.001) or bilirubin increase (p = 0.027). These endotheliopathy-related adverse events appeared early post HSCT, varied in their clinical phenotype and predicted a poor outcome. An unrelated donor but not previous exposure to leukemia or irradiation-based conditioning was identified as a risk factor for vascular complications and endotheliopathy.
Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma
Authors: Ling Zihang , Li Wei , Hu Jiaqi , Li Yuanyuan , Deng Miao , Zhang Siyuan , Ren Xianyue , Wu Tong , Xia Juan , Cheng Bin , Tao Xiaoan 
Published: February 2022

AbstractFor head and neck squamous cell carcinoma (HNSCC), the local invasion and distant metastasis represent the predominant causes of mortality. Targeted inhibition of chemokines and their receptors is an ongoing antitumor strategy established on the crucial roles of chemokines in cancer invasion and metastasis. Herein, we showed that C-C motif chemokine ligand 2 (CCL2)- C-C motif chemokine receptor 4 (CCR4) signaling, but not the CCL2- C-C motif chemokine receptor 2 (CCR2) axis, induces the formation of the vav guanine nucleotide exchange factor 2 (Vav2)- Rac family small GTPase 1 (Rac1) complex to activate the phosphorylation of myosin light chain (MLC), which is involved in the regulation of cell motility and cancer metastasis. We identified that targeting CCR4 could effectively interrupt the activation of HNSCC invasion and metastasis induced by CCL2 without the promoting cancer relapse observed during the subsequent withdrawal period. All current findings suggested that CCL2-CCR4-Vav2-Rac1-p-MLC signaling plays an essential role in cell migration and cancer metastasis of HNSCC, and CCR4 may serve as a new potential molecular target for HNSCC therapy.
Cryo-EM structure of the nuclear ring from Xenopus laevis nuclear pore complex
Authors: Huang Gaoxingyu , Zhan Xiechao , Zeng Chao , Zhu Xuechen , Liang Ke , Zhao Yanyu , Wang Pan , Wang Qifan , Zhou Qiang , Tao Qinghua , Liu Minhao , Lei Jianlin , Yan Chuangye , Shi Yigong 
Published: February 2022

AbstractNuclear pore complex (NPC) shuttles cargo across the nuclear envelope. Here we present single-particle cryo-EM structure of the nuclear ring (NR) subunit from Xenopus laevis NPC at an average resolution of 5.6 Å. The NR subunit comprises two 10-membered Y complexes, each with the nucleoporin ELYS closely associating with Nup160 and Nup37 of the long arm. Unlike the cytoplasmic ring (CR) or inner ring (IR), the NR subunit contains only one molecule each of Nup205 and Nup93. Nup205 binds both arms of the Y complexes and interacts with the stem of inner Y complex from the neighboring subunit. Nup93 connects the stems of inner and outer Y complexes within the same NR subunit, and places its N-terminal extended helix into the axial groove of Nup205 from the neighboring subunit. Together with other structural information, we have generated a composite atomic model of the central ring scaffold that includes the NR, IR, and CR. The IR is connected to the two outer rings mainly through Nup155. This model facilitates functional understanding of vertebrate NPC.
Antiferromagnetic excitonic insulator state in Sr3Ir2O7
Authors: Mazzone D. G. , Shen Y. , Suwa H. , Fabbris G. , Yang J. , Zhang S.-S. , Miao H. , Sears J. , Jia Ke , Shi Y. G. , Upton M. H. , Casa D. M. , Liu X. , Liu Jian , Batista C. D. , Dean M. P. M. 
Published: February 2022

AbstractExcitonic insulators are usually considered to form via the condensation of a soft charge mode of bound electron-hole pairs. This, however, presumes that the soft exciton is of spin-singlet character. Early theoretical considerations have also predicted a very distinct scenario, in which the condensation of magnetic excitons results in an antiferromagnetic excitonic insulator state. Here we report resonant inelastic x-ray scattering (RIXS) measurements of Sr3Ir2O7. By isolating the longitudinal component of the spectra, we identify a magnetic mode that is well-defined at the magnetic and structural Brillouin zone centers, but which merges with the electronic continuum in between these high symmetry points and which decays upon heating concurrent with a decrease in the material’s resistivity. We show that a bilayer Hubbard model, in which electron-hole pairs are bound by exchange interactions, consistently explains all the electronic and magnetic properties of Sr3Ir2O7 indicating that this material is a realization of the long-predicted antiferromagnetic excitonic insulator phase.
Recovery coupling in multilayer networks
Authors: Danziger Michael M. , Barabási Albert-László 
Published: February 2022

AbstractThe increased complexity of infrastructure systems has resulted in critical interdependencies between multiple networks—communication systems require electricity, while the normal functioning of the power grid relies on communication systems. These interdependencies have inspired an extensive literature on coupled multilayer networks, assuming a hard interdependence, where a component failure in one network causes failures in the other network, resulting in a cascade of failures across multiple systems. While empirical evidence of such hard failures is limited, the repair and recovery of a network requires resources typically supplied by other networks, resulting in documented interdependencies induced by the recovery process. In this work, we explore recovery coupling, capturing the dependence of the recovery of one system on the instantaneous functional state of another system. If the support networks are not functional, recovery will be slowed. Here we collected data on the recovery time of millions of power grid failures, finding evidence of universal nonlinear behavior in recovery following large perturbations. We develop a theoretical framework to address recovery coupling, predicting quantitative signatures different from the multilayer cascading failures. We then rely on controlled natural experiments to separate the role of recovery coupling from other effects like resource limitations, offering direct evidence of how recovery coupling affects a system’s functionality.
Photodissociation of particulate nitrate as a source of daytime tropospheric Cl2
Authors: Peng Xiang , Wang Tao , Wang Weihao , Ravishankara A. R. , George Christian , Xia Men , Cai Min , Li Qinyi , Salvador Christian Mark , Lau Chiho , Lyu Xiaopu , Poon Chun Nan , Mellouki Abdelwahid , Mu Yujing , Hallquist Mattias , Saiz-Lopez Alfonso , Guo Hai , Herrmann Hartmut , Yu Chuan , Dai Jianing , Wang Yanan , Wang Xinke , Yu Alfred , Leung Kenneth , Lee Shuncheng , Chen Jianmin 
Published: February 2022

AbstractChlorine atoms (Cl) are highly reactive and can strongly influence the abundances of climate and air quality-relevant trace gases. Despite extensive research on molecular chlorine (Cl2), a Cl precursor, in the polar atmosphere, its sources in other regions are still poorly understood. Here we report the daytime Cl2 concentrations of up to 1 ppbv observed in a coastal area of Hong Kong, revealing a large daytime source of Cl2 (2.7 pptv s−1 at noon). Field and laboratory experiments indicate that photodissociation of particulate nitrate by sunlight under acidic conditions (pH < 3.0) can activate chloride and account for the observed daytime Cl2 production. The high Cl2 concentrations significantly increased atmospheric oxidation. Given the ubiquitous existence of chloride, nitrate, and acidic aerosols, we propose that nitrate photolysis is a significant daytime chlorine source globally. This so far unaccounted for source of chlorine can have substantial impacts on atmospheric chemistry.
Waveguide coupled III-V photodiodes monolithically integrated on Si
Authors: Wen Pengyan , Tiwari Preksha , Mauthe Svenja , Schmid Heinz , Sousa Marilyne , Scherrer Markus , Baumann Michael , Bitachon Bertold Ian , Leuthold Juerg , Gotsmann Bernd , Moselund Kirsten E. 
Published: February 2022

AbstractThe seamless integration of III-V nanostructures on silicon is a long-standing goal and an important step towards integrated optical links. In the present work, we demonstrate scaled and waveguide coupled III-V photodiodes monolithically integrated on Si, implemented as InP/In0.5Ga0.5As/InP p-i-n heterostructures. The waveguide coupled devices show a dark current down to 0.048 A/cm2at −1 V and a responsivity up to 0.2 A/W at −2 V. Using grating couplers centered around 1320 nm, we demonstrate high-speed detection with a cutoff frequency f3dBexceeding 70 GHz and data reception at 50 GBd with OOK and 4PAM. When operated in forward bias as a light emitting diode, the devices emit light centered at 1550 nm. Furthermore, we also investigate the self-heating of the devices using scanning thermal microscopy and find a temperature increase of only ~15 K during the device operation as emitter, in accordance with thermal simulation results.
A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit
Authors: Rebelo-Guiomar Pedro , Pellegrino Simone , Dent Kyle C. , Sas-Chen Aldema , Miller-Fleming Leonor , Garone Caterina , Van Haute Lindsey , Rogan Jack F. , Dinan Adam , Firth Andrew E. , Andrews Byron , Whitworth Alexander J. , Schwartz Schraga , Warren Alan J. , Minczuk Michal 
Published: February 2022

AbstractMany cellular processes, including ribosome biogenesis, are regulated through post-transcriptional RNA modifications. Here, a genome-wide analysis of the human mitochondrial transcriptome shows that 2’-O-methylation is limited to residues of the mitoribosomal large subunit (mtLSU) 16S mt-rRNA, introduced by MRM1, MRM2 and MRM3, with the modifications installed by the latter two proteins being interdependent. MRM2 controls mitochondrial respiration by regulating mitoribosome biogenesis. In its absence, mtLSU particles (visualized by cryo-EM at the resolution of 2.6 Å) present disordered RNA domains, partial occupancy of bL36m and bound MALSU1:L0R8F8:mtACP anti-association module, allowing five mtLSU biogenesis intermediates with different intersubunit interface configurations to be placed along the assembly pathway. However, mitoribosome biogenesis does not depend on the methyltransferase activity of MRM2. Disruption of the MRM2Drosophila melanogasterorthologue leads to mitochondria-related developmental arrest. This work identifies a key checkpoint during mtLSU assembly, essential to maintain mitochondrial homeostasis.
Facet-dependent electrooxidation of propylene into propylene oxide over Ag3PO4 crystals
Authors: Ke Jingwen , Zhao Jiankang , Chi Mingfang , Wang Menglin , Kong Xiangdong , Chang Qixuan , Zhou Weiran , Long Chengxuan , Zeng Jie , Geng Zhigang 
Published: February 2022

AbstractThe electrooxidation of propylene into propylene oxide under ambient conditions represents an attractive approach toward propylene oxide. However, this process suffers from a low yield rate over reported electrocatalysts. In this work, we develop an efficient electrocatalyst of Ag3PO4 for the electrooxidation of propylene into propylene oxide. The Ag3PO4 cubes with (100) facets exhibit the highest yield rate of 5.3 gPO m−2 h−1 at 2.4 V versus reversible hydrogen electrode, which is 1.6 and 2.5 times higher than those over Ag3PO4 rhombic dodecahedra with (110) facets and tetrahedra with (111) facets, respectively. The theoretical calculations reveal that the largest polarization of propylene on Ag3PO4 (100) facets is beneficial to break the symmetric π bonding and facilitate the formation of C-O bond. Meanwhile, Ag3PO4(100) facets exhibit the lowest adsorption energies of *C3H6 and *OH, inducing the lowest energy barrier of the rate-determining step and thus accounting for the highest catalytic performance.
T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10
Authors: Ravi Vidhya M. , Neidert Nicolas , Will Paulina , Joseph Kevin , Maier Julian P. , Kückelhaus Jan , Vollmer Lea , Goeldner Jonathan M. , Behringer Simon P. , Scherer Florian , Boerries Melanie , Follo Marie , Weiss Tobias , Delev Daniel , Kernbach Julius , Franco Pamela , Schallner Nils , Dierks Christine , Carro Maria Stella , Hofmann Ulrich G. , Fung Christian , Sankowski Roman , Prinz Marco , Beck Jürgen , Salié Henrike , Bengsch Bertram , Schnell Oliver , Heiland Dieter Henrik 
Published: February 2022

AbstractDespite recent advances in cancer immunotherapy, certain tumor types, such as Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti-tumor immune response. Here we show, by applying an in-silico multidimensional model integrating spatially resolved and single-cell gene expression data of 45,615 immune cells from 12 tumor samples, that a subset of Interleukin-10-releasing HMOX1+ myeloid cells, spatially localizing to mesenchymal-like tumor regions, drive T-cell exhaustion and thus contribute to the immunosuppressive tumor microenvironment. These findings are validated using a human ex-vivo neocortical glioblastoma model inoculated with patient derived peripheral T-cells to simulate the immune compartment. This model recapitulates the dysfunctional transformation of tumor infiltrating T-cells. Inhibition of the JAK/STAT pathway rescues T-cell functionality both in our model and in-vivo, providing further evidence of IL-10 release being an important driving force of tumor immune escape. Our results thus show that integrative modelling of single cell and spatial transcriptomics data is a valuable tool to interrogate the tumor immune microenvironment and might contribute to the development of successful immunotherapies.