bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterning ECM microstructure to investigate 3D cellular dynamics under multiplexed mechanochemical guidance
Authors: Esfahani Pedram , Sun Bo 
Published: September 2022

Background: Biochemical and biophysical factors jointly regulate the cellular dynamics in many physiological processes. It is therefore imperative to include multiplexed microenvironment cues when employing in vitro cell-based assays to model physiological processes. Methods: To meet this need, we have developed a modular platform of 3D cell culture, Modular Control of Microenvironment for Cell Migration and Culture Assay (MC3A), that incorporates directed chemical and mechanical cues in the forms of chemotaxis and contact guidance, respectively. Taking advantage of the functionalities of MC3A, we study the migration and morphology of breast cancer cells in 3D engineered extracellular matrix (ECM) following a serum gradient for chemotaxis. Results: We show that when chemotaxis is facilitated by contact guidance in the same direction as the serum gradient, cells demonstrate dimensional-reduction in their motility and highly elongated ellipsoidal shape. When the direction of ECM alignment diverges from the direction of serum gradient, chemotactic motion is significantly suppressed, and cells are generally more protrusive and rounded in their morphology. Conclusions: These examples demonstrate MC3A as a powerful tool for engineering complex microenvironments of cells that will advance the state-of-the-art of cell-based analysis in drug development, regenerative medicine, and other research areas in bioengineering.
Nicotine products relative risk assessment: an updated systematic review and meta-analysis
Authors: Murkett Rachel , Rugh Megyn , Ding Belinda 
Published: September 2022

Background: The nicotine products relative risk assessment estimates the relative risk of tobacco-related diseases due to use of 15 nicotine products. This update adds new data to the original analysis and creates separate categories for United States and rest of world varieties of smokeless tobacco, as well as bidi cigarettes. Methods: The PubMed®, MEDLINE and Clinicaltrials.gov databases were searched systematically. The study lists were exported, screened at the title, abstract and full-text level according to pre-defined inclusion/exclusion criteria. The study quality was assessed, and risk of bias was accounted for in the screening criteria. The extracted data was synthesized into a toxin emissions/content analysis for 12 Group 1 carcinogens, used to estimate lifetime cancer risk, and epidemiological meta-analysis of over 40 tobacco-related diseases. The two analyses were integrated into a combined risk score for each nicotine product, weighted by the risk of bias due to missing data, and incorporated into the relative risk spectrum. Results: In this update, 70 new studies were added to the synthesis, making a total of 123 studies included. All combustible tobacco products score between 40 and 100, with bidis and smokeless (rest of world) also in this range. All other products have a combined risk score of 10 or less, including U.S. chewing tobacco, U.S. dipping tobacco, snus, heat-not-burn tobacco, electronic cigarettes, non-tobacco pouches and nicotine replacement therapy. Discussion: Consistent with previous studies, we define a group of high-risk nicotine products, scoring between 40 and 100 on the spectrum, and reduced risk nicotine products, scoring less than 10. Limitations of this study include the potential for bias due to missing data, the heterogeneity of the data included in the relative risk hierarchy synthesis, and the assumed consumption levels.
« Je t’aime moi non plus »
Authors: Loison-Charles Julie 
Published: September 2022

“JE T’AIME MOI NON PLUS”: THE CORRESPONDENCE BETWEEN VLADIMIR NABOKOV AND HIS FRENCH TRANSLATORS
The structure of the letters which Vladimir Nabokov sent to his French translators shows how ambivalent his relation to them was: generally, Nabokov starts by praising the beauty of the translation, and then he makes a long list of all the blunders and howlers made by the translator. This article studies three cases. First, the translation of Pale Fire is analysed as a confrontation of two very proud men, in which the famous translator Maurice Edgar Coindreau refuses to be bossed around by the novelist. Then the article presents the translation of Ada or Ardor (entrusted to Gilles Chahine) as the collaboration of “men on the verge of a nervous breakdown”. Finally, it shows the very friendly relationship which Nabokov had with Jarl Priel, the translator of Invitation to a Beheading, whom Nabokov always fiercely defended. Thanks to the correspondence between Nabokov, his translators and publishers, it will become clear that these collaborative translations were in fact “mediated self-translations”. For Nabokov, it was not just about translating his novels: he wanted to remain the full master of his creations.
Krzysztof Jarosz – traducteur multifonctionnel
Authors: Warmuzińska-Rogóż Joanna 
Published: September 2022

KRZYSZTOF JAROSZ – A MULTIFUNCTIONAL TRANSLATOR: ABOUT THE FRANKOFONIA LITERARIA COLLECTION
This article focuses on the translator’s roles that go beyond the traditional functions of the literary translator. Based on the example of the Frankofonia Literaria series and the works of Ananda Devi published in Polish in Krzysztof Jarosz’s translation, the author of the article demonstrates how the translator “comes out of the shadows,” in particular by serving as an exegete-interpreter and researcher. The translator makes himself visible in paratexts, such as footnotes or an afterword, which constitute a space where he presents himself and allows himself to be seen and read alongside the literary text.
Ethical moments and institutional expertise in UK Government COVID-19 pandemic policy responses: where, when and how is ethical advice sought?
Authors: Pykett Jessica , Ball Sarah , Dingwall Robert , Lepenies Robert , Sommer Theresa , Strassheim Holger , Wenzel Lars 
Published: September 2022

Background:The emergency response to the COVID-19 pandemic has required a rapid acceleration of policy decision making, and raised a wide range of ethical issues worldwide, ranging from vaccine prioritisation, welfare and public health ‘trade-offs’, inequalities in policy impacts, and the legitimacy of scientific expertise.
Aims and objectives:This paper explores the legacy of the pandemic for future science-advice-policy relationships by investigating how the UK government’s engagement with ethical advice is organised institutionally. We provide an analysis of some key ethical moments in the UK Government response to the pandemic, and institutions and national frameworks which exist to provide ethical advice on policy strategies.
Methods:We draw on literature review, documentary analysis of scientific advisory group reports, and a stakeholder workshop with government ethics advisors and researchers in England.
Findings:We identify how particular types of ethical advice and expertise are sought to support decision making. Contrary to a prominent assumption in the extensive literature on ‘governing by expertise’, ethical decisions in times of crisis are highly contingent.
Discussion and conclusions:The paper raises an important set of questions for how best to equip policymakers to navigate decisions about values in situations characterised by knowledge deficits, complexity and uncertainty. We conclude that a clearer pathway is needed between advisory institutions and decision makers to ensure ethically-informed debate.
Knowledge and Perception of Dental Professionals Regarding the Use of Various Safety Protocols During and after Dental Aerosol Procedures in COVID-19 Pandemic
Authors: Sharat Gurudutt Kalavar  , Bhavana B.L.  , Arundati N. Raj  , Rupesh P.L.  , Basavaraj S. Salagundi  , Tejal N. Jivrajani  
Published: September 2022

BACKGROUND
The purpose of the present study was to assess the knowledge and perception of safety protocols used before and after dental aerosol procedures among dental professionals.
METHODS
An online survey was conducted with a self-prepared questionnaire with a sample size of 354 participants consisting of postgraduate students, and dental practitioners who work in private/government institutes/hospitals. The questionnaire was prepared on Google forms and the link was circulated to postgraduate students and dental practitioners via email and WhatsApp platforms. Descriptive statistics analysis was carried out including frequency and percentage. The results of the study were tabulated.
RESULTS
94.9 % of the participants performed aerosol-generating procedures, and 76.8 % of the participants used personal protective equipment (PPE) during the procedure. 43.2 % of the participants preferred reusable elastomeric respirators with cartridges. 37.9 % of the participants responded that ventilation is the preferred method. 75.4 % of the participants felt incorrect doffing of the PPE could increase the chances of contracting the coronavirus. 83.3 % of the participants felt using PPE reduces performance and skills during dental aerosol procedures.
CONCLUSIONS
The present study revealed that 76.8 % of the participants used PPE during aerosol-generating procedures, 54 % and 39.5 % of the participants knew the first procedure in donning and doffing PPE respectively, and 73.7 % of the participants knew which area to doff the PPE in whereas only 48 % knew the correct colour of the bag in which to dispose the PPE and only 49.7 % of the participants knew when to fumigate the aerosol generated surgical area.
Evaluasi Program Sanitasi Total Berbasis Masyarakat di Wilayah Kerja Puskesmas Nangaror
Authors: Tuakong Wigberta Mogi , Nurjazuli Nurjazuli , Budiyono Budiyono 
Published: September 2022

Latar belakang: Sanitasi total berbasis masyarakat (STBM) merupakan suatu pendekatan untuk mengubah perilaku higiene dan sanitasi dengan melakukan pemicuan di komunitas. Pilar kedua dalam program program STBM adalah cuci tangan pakai sabun. Pelaksanaan STBM di Kecamatan Nangaroro selama 7 tahun mengalami peningkatan jumlah sarana cuci tangan pakai sabun yaitu sebanyak 2.014 dan yang belum memiliki sarana sebanyak 1351 rumah Penelitian ini bertujuan untuk mengevaluasi pelaksanaan cuci tangan pakai sabun di wilayah kerja Puskesmas Nangaroro.Metode: Penelitian ini menggunakan metode evaluasi dengan pendekatan kualitatif. Teknik pengambilan sampel secara purposive sampling dan dilakukan dengan wawancara mendalam. Jumlah sampel dalam penelitian ini sebanyak sebanyak 16 orang yaitu petugas sanitarian 1 orang, petugas Promkes 1 orang serta 14 orang tim STBM desa.Hasil: Penelitian ini menunjukan hanya ada satu orang petugas sanitarian, tidak ada sarana transportasi, dan tidak adanya evaluasi lintas sektor.Simpulan: Penelitian ini adalah pelaksanaan program STBM pilar kedua cuci tangan pakai sabun di wilayah kerja Puskesmas Nangaroro belum dapat berjalan dengan baik karena terdapat beberapa kendala dalam pelaksanaanya. Diharapkan adanya pendampingan dan keikutsertaan dari Dinas Kesehatan Kabupaten Nagekeo dalam pelaksanaan program STBM.Kata kunci: Evaluasi, STBM, cuci tangan, sabun ABSTRACT Title: Community Based Total Sanitation Program Evaluation in The Working Area of The Nangaror PuskesmasBackground: Community-based total sanitation (STBM) is an approach to change hygiene and sanitation behavior by triggering in the community. The second pillar in the STBM program is washing hands with soap. The implementation of STBM in Nangaroro Subdistrict for 7 years has increased the number of means of washing hands with soap, namely 2,014 and 1351 houses that do not have the facilities. This research aims to evaluate the implementation of washing hands with soap in the work area of the Nangaroro Health Center.Method: This study uses an evaluation method with a qualitative approach. The sampling technique was purposive sampling and carried out by in-depth interviews. The number of samples in this study were 16 people, namely 1 sanitarian officer, 1 Promkes officer and 14 village STBM teams.Result: This research shows that there is only one sanitarian officer, no means of transportation, and no cross-sectoral evaluation.Conclusion: This research is the implementation of the second pillar STBM program washing hands with soap in the work area of the Nangaroro Health Center has not been able to run properly because there are several obstacles in its implementation. It is hoped that there will be assistance and participation from the Nagekeo District Health Office in the implementation of the STBM program.Keywords: Evaluation, STBM, wash hands, soap
Literature Review : Faktor Risiko Penyebab Obesitas
Authors: Saraswati Siwi Kurnia , Rahmaningrum Faikha Dhista , Pahsya M Naufal Zidane , Paramitha Nadhila , Wulansari Arum , Ristantya Alfandira Rossa , Sinabutar Beatrix Magdalena , Pakpahan Vina Estetika , Nandini Nurhasmadiar 
Published: September 2022

ABSTRAKLatar belakang: Obesitas merupakan suatu masalah gizi yang belakangan tumbuh dengan pesat baik di kalangan ekonomi menengah ke atas maupun menengah ke bawah. Tujuan dari penelitian ini adalah untuk melihat faktor penyebab obesitas berdasar teori H.L. Blum.Metode: Desain penelitian yang digunakan dalam penelitian ini adalah dengan menggunakan metode Literature review. Teknik ini dilakukan dengan tujuan untuk mengungkapkan berbagai teori-teori yang relevan dengan permasalahan yang sedang dihadapi atau diteliti sebagai bahan rujukan dalam pembahasan hasil penelitian. Dalam penelitian ini penulis memilih artikel penelitian kuantitatif dengan desain cross sectional atau case control.Hasil: Hasil penelitian dari tinjauan artikel diketahui faktor penyebab obesitas berdasarkan teori H.L. Blum. Faktor yang mempengaruhi kejadian obesitas terdiri dari faktor lingkungan yaitu aktivitas fisik hanya sebagai trend dan pilihan makanan yang beragam, faktor pelayanan kesehatan yaitu pengaruh penyuluhan, faktor genetik yaitu usia, jenis kelamin, parental fatness, mutase gen, dan faktor perilaku yaitu pola makan dan kurangnya aktivitas fisik.Simpulan: Kejadian obesitas dipengaruhi oleh banyak faktor di antaranya faktor lingkungan, pelayanan kesehatan, genetik, dan perilaku.Kata kunci: Obesitas, lingkungan, pelayanan kesehatan, genetik, perilaku ABSTRACT Title: Literature Review: Risk Factors for Causes of ObesityBackground: Obesity is a nutritional problem that has recently grown rapidly both in the middle to upper and lower middle class economies. The purpose of the research is to looked at the causes of obesity based on H.L. Blum Theory.Method: The research design used in this study is to use the Literature review method. This technique is carried out with the aim of expressing various theories that are relevant to the problem being faced or being researched as reference material in the discussion of research results. In this study, the authors chose a quantitative research article with a cross sectional design or case control design.Result: The result of the research from the article review found that the causes of obesity based on the theory of H.L. Blum. Factors that cause the incidence of obesity consist of environmental factors, namely physical activity only as a trend and various food choices, health service factors, namely the influence of counseling, genetic factors namely age, gender, parental fatness, gene mutation, and behavioral factors, namely diet and lack of health. physical activity.Conclusion: Obesity is caused by many factors including environmental factors, health services, genetics, and behavior.Keywords: Obesity, environment, health care, genetics, behavior
Pengaruh Pandemi Covid-19 terhadap Pelayanan Imunisasi Rutin pada Anak: Kajian Literatur
Authors: Indahsari Ratna 
Published: September 2022

Latar belakang: Pandemi COVID-19 telah memberikan dampak terhadap sistem pelayanan kesehatan, yaitu terganggunya pelayanan kesehatan dasar seperti pelayanan imunisasi rutin. Penelitian ini bertujuan untuk mengetahui pengaruh pandemi COVID-19 terhadap layanan imunisasi rutin serta faktor-faktor yang mempengaruhinya.Metode: Penelitian ini menggunakan metode kajian literatur dengan menggunakan data sekunder yang berasal dari publikasi literatur terdahulu. Terdapat total 17.500 publikasi yang teridentifikasi berkaitan dengan topik yang dicari. Setelah dilakukan screening kedua dengan menggunakan cakupan tahun publikasi dari tahun 2020-2021 maka didapatkan 36 publikasi.Hasil: Beberapa negara di dunia mengalami penurunan cakupan imunisasi dan pemanfaatan layanan selama pandemi COVID-19. Faktor-faktor yang mempengaruhi hal tersebut yaitu ketakutan masyarakat akan terpapar virus COVID-19, ketidaksiapan sistem pelayanan kesehatan dan keterbatasan mobilitas masyarakat. Dalam mengatasi dampak disrupsi imunisasi rutin, tenaga kesehatan dan pemerintah harus berupaya untuk meningkatkan cakupan dan target imunisasi yang mengalami ketertinggalan.Simpulan: Adanya pandemi COVID-19 mempengaruhi terdisrupsinya layanan kesehatan esensial termasuk layanan imunisasi, menyebabkan menurunnya cakupan imunisasi PD3I, dan dapat berisiko terhadap timbulnya masalah kesehatan lain seperti kejadian luar biasa (KLB) PD3I.Kata Kunci: Imunisasi Rutin; Covid-19; Dampak Disrupsi Layanan Imunisasi ABSTRACT Title: The Effect of The Covid-19 Pandemic on Routine Immunization Services for Children: Literature ReviewBackground: The COVID-19 pandemic is impacting on the health care system, namely the disruption of basic health services such as routine immunization services. This study aims to determine the impact of the COVID-19 pandemic on routine immunization services as well as the factors that affect them. Method: This study conducted literature review method using secondary data derived from previous literature publications. Result: Some countries around the world had reported a decrease in immunization coverage and service utilization during the COVID-19 pandemic. Factors that influence this are people's fear of exposure to the COVID-19 virus, unpreparedness of the health care system and limited mobility of the community. In addressing the impact of routine immunization disruptions, health workers and governments should strive to improve the coverage and targets of immunizations. Conclusion: The existence of the COVID-19 pandemic affects the disruption of essential health services including immunization services, causes a decrease in PD31 immunization coverage, and can be a risk of other health problems such as PD31 outbreaks. Keyword: Routine Immunization; Covid-19; Disruption Immunization Services Impact
Pelaksanaan Tujuh Langkah Menuju Keselamatan Pasien di Puskesmas X Kabupaten Demak
Authors: Putri Farah Afanindya Jessedanta , Arso Septo Pawelas , Budiyanti Rani Tiyas 
Published: September 2022

Latar Belakang: Keselamatan pasien merupakan salah satu isu penting dalam pelayanan kesehatan. Penelitian ini menganalisis pelaksanaan program keselamatan pasien ditinjau dari tujuh langkah menuju keselamatan pasien di Puskesmas X Kabupaten Demak.Metode: Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Subjek penelitian ini adalah informan utama yaitu anggota keselamatan pasien, dan informan triangulasi yaitu kepala puskesmas, kepala tata usaha, ketua UKM, dan pasien.Hasil: Berdasarkan hasil penelitian masih ditemukan adanya insiden, terjadi keterlambatan pelaporan, tidak adanya agenda khusus keselamatan pasien, pelaporan hanya untuk internal, selama pandemi COVID-19 pelaksanaan keselamatan pasien kurang optimal.Simpulan: Tujuh langkah menuju keselamatan pasien di puskesmas X Kabupaten Demak belum terlaksana dengan optimal.Kata Kunci : Keselamatan pasien; tujuh langkah menuju keselamatan pasien; puskesmas; insiden keselamatan pasien ABSTRACT Title: Implementation of The Seven Steps to Patient Safety at Puskesmas X Demak Background: Patient safety is one of the important issues in health care. This study proves the safety program of the seven steps towards safety at Puskesmas X Demak district. Method: This study uses a qualitative method with a descriptive approach. The subjects of this study were the main informants, namely members of patient safety, and triangulation of informants, namely the head of the puskesmas, the head of administration, the head of the UKM, and the patient. Result: The results of the study, it was still found that there were incidents, there were delays in reporting, there was no special patient safety agenda, reporting was only for internal, during the COVID-19 pandemic the implementation of patient safety was less than optimal.Conclusion: Seven steps towards patient safety at Puskesmas X, Demak district have not been implemented optimally.Keywords: Patient safety; seven steps to patient safety; puskesmas; patient safety
Pelaksanaan Jaminan Kesehatan Nasional pada Aspek Kepesertaan untuk Mencapai Universal Health Coverage
Authors: Putri Syifa Shidqi , Suryawati Chriswardani 
Published: September 2022

Latar belakang: Jaminan Kesehatan Nasional di suatu negara adalah program yang dibentuk untuk mencapai Cakupan Kesehatan Semesta guna memastikan bahwa setiap warga negara dalam populasi memiliki akses ke layanan kesehatan dengan partisipasi wajib. Dalam perkembangan pelaksanaan JKN terdapat permasalahan yaitu penurunan kepesertaan yang menjadi alasan peneliti melakukan penelitian untuk menganalisis faktor-faktor yang berkaitan dengan kepesertaan JKN, hambatan, serta upaya mempertahankan dan meningkatkan kepesertaan.Metode: Metode dalam penelitian ini adalah Literature Review dengan metode analisis data sederhana (simplified approach). Terdapat 12 artikel nasional dan 3 artikel internasional yang telah dipilih oleh peneliti sebagai bahan penelitian.Hasil: Hasil penelitian menunjukkan bahwa faktor-faktor yang berhubungan dengan kepesertaan BPJS Kesehatan dibagi menjadi 3 faktor utama, yaitu faktor predisposisi, faktor pendukung, dan faktor kebutuhan. Hambatan pelaksanaan JKN ditemukan pada aspek pendaftaran, manfaat yang diterima, dan kualitas layanan yang buruk.Simpulan: Faktor yang berhubungan dengan kepesertaan Jaminan Kesehatan Nasional adalah faktor umur, jenis kelamin, pendidikan, pekerjaan, jumlah anggota keluarga, pengetahuan, pendapatan, dukungan keluarga dan sosial, persepsi serta motivasi. Kata kunci: Jaminan Kesehatan Nasional; Partisipasi; Cakupan Kesehatan Semesta ABSTRACT Title: Implementation of National Health Insurance in Participation Aspects to Achieving Universal Health CoverageBackground: National Health Insurance in a country is a program formed to achieve Universal Health Coverage and to ensure that every citizen in the population has access to health services with mandatory participation. In the development of the implementation of JKN, there is a problem, namely a decrease in participation, which is the reason researchers conduct research to analyze factors related to JKN participation, barriers, and efforts to maintain and increase participation. Method: The method in this research is Literature Review with a simple data analysis method (simplified approach). There are 12 national articles and 3 international articles that have been selected by researchers as research material. Result: The results showed that the factors related to BPJS Health participation were divided into 3 main factors, namely predisposing factors, supporting factors, and needs factors. Barriers to the implementation of JKN were found in aspects of registration, benefits received, and poor service quality.Conclusion: Related factor to participation in National Health Insurance are age, gender, education, occupation, number of members, knowledge, income , family and social support, family perception and motivation.Keywords: National Health Insurance; Participation; Universal Health Coverage