bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood cancer survivorship in China: An overview of the past two decades
Authors: Ji Xu , Su Jun , Liu Xinyu , Mao Ziling , Zhang Wenjing , Zhang Jinhe , Sun Xiaojie , Han Xuesong 
Published: May 2022

AbstractAcross countries in the world, China has the largest population of childhood cancer survivors. Research and care for the childhood cancer survivor population in China is fragmented. We searched studies published in English or Chinese language between January 1, 2000 and June 30, 2021, which examined various aspects of childhood cancer survivorship in China. The existing China‐focused studies were largely based on a single institution, convenient samplings with relatively small sample sizes, restricted geographic areas, cross‐sectional design, and focused on young survivors in their childhood or adolescence. These studies primarily focused on the physical late effects of cancer and its treatment, as well as the inferior psychological wellbeing among childhood cancer survivors, with few studies examining financial hardship, health promotion, and disease prevention, or healthcare delivery in survivorship. Our findings highlight the urgent need for research and evidence‐based survivorship care to serve the childhood cancer survivor population in China.
An Environmentally Sustainable Synthesis of Enantioenriched CF3‐Chromanol, Indanol and Tetralol Derivatives by Rh‐Catalyzed Asymmetric Transfer Hydrogenation
Authors: Molina Betancourt Ricardo , Bacheley Lucas , Karapetyan Anzhela , Guillamot Gérard , Phansavath Phannarath , Ratovelomanana‐Vidal Virginie 
Published: May 2022

AbstractThe Rh(III)‐catalyzed asymmetric reduction of α‐trifluoromethyl ketones through transfer hydrogenation was developed under mild conditions to access a series of enantioenriched cis‐trifluoromethyl alcohols via a dynamic kinetic resolution process. The reaction was efficiently performed in the green solvent 2‐MeTHF with HCO2H/Et3N (1 : 1) as the hydrogen source. High yields, alongside excellent diastereo‐ and enantioselectivities were obtained for the synthesis of CF3‐chromanol, CF3‐indanol and CF3‐tetralol derivatives.
Cage‐Ligand Strategy for the Construction of Zr4(embonate)6–Based MOFs with Third‐Order Nonlinear‐Optical Properties
Authors: Teng Qian , He Yan‐Ping , Chen Guang‐Hui , Chen Shu‐Mei 
Published: May 2022

Comprehensive SummaryHerein, we demonstrate a very useful strategy to construct cage‐based metal‐organic frameworks (MOFs) with third‐order nonlinear‐optical properties. More specifically, by employing the Zr4L6 (L = embonate) cages to assembly with N‐contained ligands and Mn2+/Zn2+ ions, four Zr4L6‐cage‐based MOFs have been synthesized and structurally characterized. Among them, a 3D framework with strong aromatic π − π stacking force exhibits a good optical limiting effect.
New persistent opioid use among adolescents and young adults with sarcoma
Authors: Beauchemin Melissa P. , Raghunathan Rohit R. , Accordino Melissa K. , Cogan Jacob C. , Kahn Justine M. , Wright Jason D. , Hershman Dawn L. 
Published: May 2022

BackgroundAdolescents and young adults (AYA) with sarcoma experience both acute and chronic pain related to their disease and treatment. Studies in older adults have reported a high risk of persistent opioid use after cancer therapy among previously opioid‐naive patients; however, few studies have evaluated posttreatment opioid use among AYAs. This article describes patterns of new persistent opioid use among AYAs in the year after treatment for sarcoma.MethodsOpioid‐naive patients who were 10 to 26 years old and diagnosed with sarcoma (2008‐2016) were identified with the IBM Marketscan Database. Included subjects had an International Classification of Diseases code for sarcoma (ninth or tenth revision), received anticancer therapy (chemotherapy, surgery, and/or radiation) within 30 days of the first diagnosis code, and had continuous insurance coverage (commercial or Medicaid) for more than 12 months both before the diagnosis and after the last therapy. The primary outcome was new persistent opioid use, which was defined as at least 2 opioid prescriptions in the 12 months following treatment completion. Covariates included age, sex, insurance, tumor type, surgical procedure, mental health (MH) or substance use diagnoses before or during therapy, and concomitant lorazepam use.ResultsIn total, 938 patients met the inclusion criteria; 521 (56%) were male, and 578 (62%) were younger than 18 years. In total, 727 (78%) had commercial insurance, and 273 (29%) had an MH diagnosis either before or during the treatment period. Of the total group, 464 (49%) used opioids during treatment only. Of those who used opioids during treatment, 135 (23%) received at least 2 prescriptions in the year after therapy. In a multivariable analysis, Medicaid versus commercial insurance (odds ratio [OR], 1.74; 95% confidence interval [CI], 1.15‐2.64) and non–soft tissue sarcoma (OR for Ewing sarcoma, 3.23; 95% CI, 1.81‐5.78; OR for osteosarcoma, 2.05; 95% CI, 1.36‐3.09) conferred a higher likelihood of new persistent use.ConclusionsIn this cohort of AYAs treated for sarcoma, 64% of the patients received opioid prescriptions during treatment, and 23% of these patients became new persistent users. Because of the risks associated with persistent opioid use, studies of novel pain management strategies along with age‐appropriate education and anticipatory guidance are urgently needed.Lay Summary

Using an insurance claims database, we conducted a study to determine the rate of new persistent opioid use among adolescents and young adults treated for sarcoma.

We found that 64% of adolescents and young adults treated for sarcoma received opioid prescriptions during treatment, and 23% of these patients met the criteria for new persistent opioid use.

These findings support the need for age‐appropriate education and novel pain management strategies in this vulnerable population.
Noble Metal‐Free Inorganic Photocatalyst Consisting of Antimony‐Doped Tin Oxide Nanorod and Titanium oxide for Two‐Electron Oxygen Reduction Reaction
Authors: Suzuki Haruya , Yamauchi Junpei , Naya Shin‐ichi , Sugime Hisashi , Tada Hiroaki 
Published: May 2022

AbstractThis study reports a noble metal‐free robust inorganic photocatalyst for H2O2 synthesis via two‐electron oxygen reduction reaction (ORR). Antimony‐doped tin oxide nanorods were heteroepitaxially grown from rutile TiO2 seed crystals with an orientation of (001)ATO//(001)TiO2 (ATO−NR//TiO2,//denotes heteroepitaxial junction) by a hydrothermal method. UV‐light irradiation of ATO−NR//TiO2 particles stably and continuously produces H2O2 from aerated aqueous solution of ethanol. Electrochemical measurements using rotating electrodes show that Sb‐doping into SnO2 greatly enhances the electrocatalytic activity for two‐electron ORR. The striking photocatalytic activity of ATO−NR//TiO2 stems from the effective charge separation, electrocatalytic activity for two‐electron ORR, low catalytic activity for H2O2 decomposition, and extraordinary robustness.
Importance of crosstalk between the microbiota and the neuroimmune system for tissue homeostasis
Authors: Li Kunyu , Ly Kevin , Mehta Sunali , Braithwaite Antony 
Published: May 2022

AbstractThe principal function of inflammation is cellular defence against ‘danger signals’ such as tissue injury and pathogen infection to maintain the homeostasis of the organism. The initiation and progression of inflammation are not autonomous as there is substantial evidence that inflammation is known to be strongly influenced by ‘neuroimmune crosstalk’, involving the production and expression of soluble signalling molecules that interact with cell surface receptors. In addition, microbiota have been found to be involved in the development and function of the nervous and immune systems and play an important role in health and disease. Herein, we provide an outline of the mechanisms of neuroimmune communication in the regulation of inflammation and immune response and then provide evidence for the involvement of microbiota in the development and functions of the host nervous and immune systems. It appears that the nervous and immune systems in multicellular organisms have co‐evolved with the microbiota, such that all components are in communication to maximise the ability of the organism to adapt to a wide range of environmental stresses to maintain or restore tissue homeostasis.
Short‐term effects of dapagliflozin on maximal functional capacity in heart failure with reduced ejection fraction (DAPA‐VO2): a randomized clinical trial
Authors: Palau Patricia , Amiguet Martina , Domínguez Eloy , Sastre Clara , Mollar Anna , Seller Julia , Garcia Pinilla Jose Manuel , Larumbe Ainoha , Valle Alfonso , Gómez Doblas Juan Jose , de la Espriella Rafael , Miñana Gema , Mezcua Ainhoa Robles , Santas Enrique , Bodí Vicent , Sanchis Juan , Pascual‐Figal Domingo , Górriz Jose Luis , Baýes‐Genís Antonio , Núñez Julio ,   the DAPA‐VO Investigators (see Appendix)
Published: May 2022

AbstractAimsThis study aimed to evaluate the effect of dapagliflozin on 1 and 3‐month maximal functional capacity in patients with stable heart failure with reduced ejection fraction (HFrEF).Methods and resultsIn this multicentre, randomized, double‐blind clinical trial, 90 stable patients with HFrEF were randomly assigned to receive either dapagliflozin (n = 45) or placebo (n = 45). The primary outcome was a change in peak oxygen consumption (peakVO2) at 1 and 3 months. Secondary endpoints were changes at 1 and 3 months in 6‐min walk test (6MWT) distance, quality of life (Minnesota Living with Heart Failure Questionnaire [MLHFQ]), and echocardiographic parameters (diastolic function, left chamber volumes, and left ventricular ejection fraction). We used linear mixed regression analysis to compare endpoint changes. Estimates were adjusted for multiple comparisons. The mean age was 67.1 ± 10.7 years, 69 (76.7%) were men, 29 (32.2%) had type 2 diabetes, and 80 (88.9%) were in New York Heart Association class II. Baseline means of peakVO2, 6MWT and MLHFQ were 13.2 ± 3.5 ml/kg/min, 363 ± 110 m, and 23.1 ± 16.2, respectively. The median (25th–75th percentile) of N‐terminal pro‐brain natriuretic peptide was 1221 pg/ml (889–2100). Most patients were on treatment with sacubitril/valsartan (88.9%), beta‐blockers (91.1%), and mineralocorticoid receptor antagonists (74.4%). PeakVO2 significantly increased in patients on treatment with dapagliflozin (1 month: +Δ 1.09 ml/kg/min, 95% confidence interval [CI] 0.14–2.04; p = 0.021, and 3 months: +Δ 1.06 ml/kg/min, 95% CI 0.07–2.04; p = 0.032). Similar positive findings were found when evaluating changes from baseline. No significant differences were observed in secondary endpoints.ConclusionsAmong patients with stable HFrEF, dapagliflozin resulted in a significant improvement in peakVO2 at 1 and 3 months.Clinical Trial Registration:
ClinicalTrials.gov Identifier: NCT04197635.
Sex and central obesity in heart failure with preserved ejection fraction
Authors: Sorimachi Hidemi , Omote Kazunori , Omar Massar , Popovic Dejana , Verbrugge Frederik H. , Reddy Yogesh N.V. , Lin Grace , Obokata Masaru , Miles John M. , Jensen Michael D. , Borlaug Barry A. 
Published: May 2022

AbstractAimsObesity is a risk factor for heart failure with preserved ejection fraction (HFpEF), particularly in women, but the mechanisms remain unclear. The present study aimed to investigate the impact of central adiposity in patients with HFpEF and explore potential sex differences.Methods and resultsA total of 124 women and 105 men with HFpEF underwent invasive haemodynamic exercise testing and rest echocardiography. Central obesity was defined as a waist circumference (WC) ≥88 cm for women and ≥102 cm for men. Exercise‐normalized pulmonary capillary wedge pressure (PCWP) responses were evaluated by the ratio of PCWP to workload (PCWP/W) and after normalizing to body weight (PCWL). The prevalence of central obesity (77%) exceeded that of general obesity (62%) defined by body mass index ≥30 kg/m2. Compared to patients without central adiposity, patients with HFpEF and central obesity displayed greater prevalence of diabetes and dyslipidaemia, higher right and left heart filling pressures and pulmonary artery pressures during exertion, and more severely reduced aerobic capacity. Associations between WC and fasting glucose, low‐density lipoprotein (LDL) cholesterol, peak workload, and pulmonary artery pressures were observed in women but not in men with HFpEF. Although increased WC was associated with elevated PCWP in both sexes, the association with PCWP/W was observed in women but not in men. The strength of correlation between PCWP/W and WC was more robust in women with HFpEF as compared to men (Meng's test p = 0.0008), and a significant sex interaction was observed in the relationship between PCWL and WC (p for interaction = 0.02).ConclusionsCentral obesity is even more common than general obesity in HFpEF, and there appear to be important sexual dimorphisms in its relationships with metabolic abnormalities and haemodynamic perturbations, with greater impact in women.
Amidinato Isopropylmethylamidosilylene‐Catalyzed Hydroboration of Carbonyl Compounds
Authors: Lee Jiawen , Fan Jun , Koh An‐Ping , Joslyn Cheang Wan‐Jun , Yang Ming‐Chung , Su Ming‐Der , So Cheuk‐Wai 
Published: May 2022

AbstractThis study describes the use of an amidinato isopropylmethylamidosilylene [LSiN(Me)iPr] (1, L=PhC(NtBu)2) to catalyze hydroboration of carbonyl compounds. Compound 1 (loading: 5–10 mol%) was shown to be an efficient catalyst for the chemoselective hydroboration of aldehydes (average yield=97 %, average TOF=8.8 h−1) and ketones (average yield=97 %, average TOF=1.7 h−1) with pinacolborane (HBpin) in C6D6 at 90 °C to form borate esters. Mechanistic studies show that the Si lone pair electrons on 1 and the B vacant p orbital of HBpin activates the C=O double bond of aldehydes and ketones, the intermediates of which undergoes hydroboration to yield borate esters and regenerate compound 1.
A Cu Nanoparticles‐Assisted‐Catalysis Method Enables Controllably Direct Growth of Graphene Transparent Conductive Films on SiO2 Nanospheres Antireflection Layer
Authors: Yin Wanying , Huang Yue , Lu Meng , Li Dezeng 
Published: May 2022

AbstractThe regulation of catalyst distribution is crucial to enhance transmittance of graphene transparent conductive films (TCFs) maintaining their high electrical properties in the chemical vapor deposition (CVD) process. We successfully regulated the distribution of Cu nanoparticles (NPs) and realized the controllable deposition of graphene on the insulating substrates coated with SiO2 nanospheres antireflection (SiO2 NSs AR). The graphene/SiO2 NSs AR composite TCFs prepared with optimized conditions have transmittance of 95.86 % and sheet resistance of 0.934 kΩ ⋅ sq−1. Compared with graphene TCFs with a whole coated distribution of Cu NPs, the optical properties of graphene/SiO2 NSs AR composite TCFs were significantly improved. Meanwhile, it can maintain a comparable or even lower sheet resistance. This method is easier‐operational, low‐cost and lays a foundation for preparing high‐quality graphene TCFs for future electronic devices.
Rhodium(III)‐Catalyzed Heteroannulations of 3‐Sulfolene Derivatives through C(sp2)−H Activation: Access to Pyridine ortho‐Quinodimethane Precursors
Authors: Saiegh Tomas J. , Meyer Christophe , Cossy Janine 
Published: May 2022

AbstractHydroxamates derived from 3‐sulfolene‐3‐carboxylic acid can be involved in intra‐ and intermolecular rhodium(III)‐catalyzed heteroannulations with alkynes proceeding through C(sp2)−H bond activation. These transformations allow for a straightforward access to diversely substituted pyridones, and to pyridines fused to a sulfolene ring after functional group transformations. Subsequent cheletropic elimination of sulfur dioxide can be achieved under microwave irradiation to generate pyridine ortho‐quinodimethanes. These results demonstrate that the scope of rhodium(III)‐catalyzed C(sp2)−H functionalizations can be extended to sulfolenes, a yet unexplored class of alkenes in these latter transformations, thereby affording access to valuable classes of heterocyclic products.
Equity and balance in applied dementia research: A charter of conduct and checklist for global collaborations
Authors: Leroi Iracema , Karanja Wambui , Adrion Emily R. , Alladi Suvarna , Custodio Nilton , Goswami S. P. , Guerchet Maëlenn , Gubner Jennie , Ibanez Agustin , Ilinica Stefania , Jafri Hussain , Lawlor Brian , Mohamed Aya Ashour , Ogunniyi Adesola , Robertson Ian , Robinson Louise , Spector Aimee , Varghese Mathew , Weidner Wendy , Caramelli Paulo ,   Dementia Charter of Conduct Global Expert Reference Group
Published: May 2022

Key points

Equity and balance in international partnerships between high‐ and low‐and‐middle income countries for applied dementia research may guard against research imperialism.

International partnerships should be transparent, fair, inclusive, sustainable and involve bidirectional learning.

International partnerships should include capacity and capability building for dementia research.

International partnerships should include key stakeholders across the dementia community including people with lived experience, care partners, and civic society.
Characterization and role of collagen gene expressing hepatic cells following partial hepatectomy in mice
Authors: Kimura Yusuke , Koyama Yukinori , Taura Kojiro , Kudoh Aoi , Echizen Kanae , Nakamura Daichi , Li Xuefeng , Nam Nguyen Hai , Uemoto Yusuke , Nishio Takahiro , Yamamoto Gen , Seo Satoru , Iwaisako Keiko , Watanabe Akira , Hatano Etsuro 
Published: May 2022

Background and Aims:
The mechanism underlying liver regeneration following partial hepatectomy (PH) is not fully elucidated. We aimed to characterize collagen gene expressing hepatic cells following PH and examine their contribution to liver regeneration.

Approach and Results:
Col‐GFP mice, which express GFP under the control of the collagen gene promoter, were used to detect collagen gene expressing cells following PH. The GFP‐expressing cells were analyzed via single‐cell RNA sequencing (scRNA‐seq). Additionally, Col‐ER Cre/RFP and Col‐ER Cre/DTA mice were utilized to examine the cell fates and functional roles of collagen gene expressing cells in liver regeneration, respectively. The number of collagen gene expressing cells was found to be increased on day 3 and subsequently decreased on day 7 following PH. ScRNA‐seq analysis of sorted collagen gene expressing cells showed that the regenerating liver was characterized by three distinct hepatic stellate cell (HSC) clusters, including one representing classic myofibroblasts. The other HSC clusters included an intermediately activated HSC cluster and a proliferating HSC cluster. Of these, the latter cluster was absent in the CCl4‐induced liver fibrosis model. Cell fate tracing analysis using Col‐ER Cre/RFP mice demonstrated that the collagen gene expressing cells escaped death during regeneration and remained in an inactivated state in the liver. Further, depletion of these cells using Col‐ER Cre/DTA mice resulted in impaired liver regeneration.

Conclusions:
Heterogeneous HSC clusters, one of which was a unique proliferating cluster, were found to appear in the liver following PH. Collagen gene expressing cells, including HSCs, were found to promote liver regeneration.
PAR2 promotes impaired glucose uptake and insulin resistance in NAFLD through GLUT2 and Akt interference
Authors: Shearer Andrew M. , Wang Yanling , Fletcher Elizabeth K. , Rana Rajashree , Michael Emily S. , Nguyen Nga , Abdelmalek Manal F. , Covic Lidija , Kuliopulos Athan 
Published: May 2022

Abstract

Background and Aims
Insulin resistance and poor glycemic control are key drivers of the development of NAFLD and have recently been shown to be associated with fibrosis progression in NASH. However, the underlying mechanisms involving dysfunctional glucose metabolism and relationship with NAFLD/NASH progression remain poorly understood. We set out to determine whether protease‐activated receptor 2 (PAR2), a sensor of extracellular inflammatory and coagulation proteases, links NAFLD and NASH with liver glucose metabolism.

Approach and Results
Here, we demonstrate that hepatic expression of PAR2 increases in patients and mice with diabetes and NAFLD/NASH. Mechanistic studies using whole‐body and liver‐specific PAR2‐knockout mice reveal that hepatic PAR2 plays an unexpected role in suppressing glucose internalization, glycogen storage, and insulin signaling through a bifurcating Gq‐dependent mechanism. PAR2 activation downregulates the major glucose transporter of liver, GLUT2, through Gq‐MAPK‐FoxA3 and inhibits insulin‐Akt signaling through Gq‐calcium‐CaMKK2 pathways. Therapeutic dosing with a liver‐homing pepducin, PZ‐235, blocked PAR2‐Gq signaling and afforded significant improvements in glycemic indices and HbA1c levels in severely diabetic mice.

Conclusions
This work provides evidence that PAR2 is a major regulator of liver glucose homeostasis and a potential target for the treatment of diabetes and NASH.
Metabolic regulation of type 2 immune response during tissue repair and regeneration
Authors: Ding Tian , Ge Shaohua 
Published: May 2022

AbstractType 2 immune responses are mediated by the cytokines interleukin (IL)-4, IL-5, IL-10, and IL-13 and associated cell types, including T helper (Th)2 cells, group 2 innate lymphoid cells (ILC2s), basophils, mast cells, eosinophils, and IL-4- and IL-13-activated macrophages. It can suppress type 1-driven autoimmune diseases, promote antihelminth immunity, maintain cellular metabolic homeostasis, and modulate tissue repair pathways following injury. However, when type 2 immune responses become dysregulated, they can be a significant pathogenesis of many allergic and fibrotic diseases. As such, there is an intense interest in studying the pathways that modulate type 2 immune response so as to identify strategies of targeting and controlling these responses for tissue healing. Herein, we review recent literature on the metabolic regulation of immune cells initiating type 2 immunity and immune cells involved in the effector phase, and talk about how metabolic regulation of immune cell subsets contribute to tissue repair. At last, we discuss whether these findings can provide a novel prospect for regenerative medicine.
Notch regulatesHistoplasma capsulatumclearance in mouse lungs during innate and adaptive immune response phases in primary infection
Authors: Huang Shuo , Deepe George S 
Published: May 2022

AbstractThe clearance of the pathogenic fungus, Histoplasma capsulatum, requires cooperation between innate and adaptive immunity. Since this organism is inhaled, lung macrophages and dendritic cells (DCs) are the first lines of defense. Moreover, DCs act as APCs to drive the education of type 1 Th cells to produce IFNγ, which contributes to the final elimination of H. capsulatum. In this study, we explored the importance of Notch signaling in host defenses using a mouse model of pulmonary histoplasmosis. We found up-regulation of Notch ligands (NLs) and Notch receptors (NRs) on phagocytes and IFNγ+ CD4+ T cells upon infection in lungs and lymph nodes. To ascertain the influence of Notch on the course of infection, we used a gamma-secretase inhibitor (GSI), LY-411,575, which inhibits NR downstream signaling. This compound impaired fungal clearance when given at the time of infection or 7 days after infection. However, GSI did not impact fungal clearance in mice with preexisting immunity. The dampened host defenses were associated with reduced differentiation and maturation of monocyte-derived DCs and elevatmonocyte-derived macrophage and alveolar macrophage polarization to M2. Our study reveals the critical nature of Notch signaling in maintaining control of this infectious agent.