bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-parametric perspective of the North Atlantic eddy-driven jet
Authors: Barriopedro David , Ayarzagüena Blanca , García-Burgos Marina , García-Herrera Ricardo 
Published: November 2022

AbstractThe North Atlantic eddy-driven jet (EDJ) is an essential component of the Euro-Atlantic atmospheric circulation. It has been typically described in terms of latitude and intensity but this is not enough to fully characterize its variability and complex EDJ configurations. Here, we present a set of daily parameters of the EDJ based on low-tropospheric zonal wind data for the 1948–2020 period. They describe the intensity, sharpness, location, edges, tilt and other zonal asymmetries of the EDJ, therefore dissecting its structure beyond the latitudinal regimes. This allows for assessments of specific EDJ aspects and a multi-parametric treatment of EDJ configurations in a manageable way. Overall, variations in EDJ parameters reflect distinctive patterns of eddy forcing and wave breaking, with anticyclonic eddies playing a major role in shaping the EDJ structure. A multimodal behavior of the EDJ is only detected in latitude, which largely influences the longitudinal position of the EDJ. Other aspects of the EDJ are less constrained by the latitude and display a variety of configurations. Four multi-parametric states (northern, central, tilted and split EDJs) provide a satisfactory description of recurrent patterns of the EDJ. They participate in meridional migrations of the EDJ, but yield less dramatic transitions than viewed from the latitudinal perspective. Finally, the EDJ parameters help to better understand the EDJ influence on European climate. In many regions, latitude and intensity contain limited information on near-surface anomalies, and their signals can be masked by the additional effect of other EDJ parameters.
Ossification of the posterior capitellum: description of a new pathology and its radiological appearance
Authors: Schneider M. M. , Hollinger B. , Zimmerer A. , Nietschke R. , Michaely H. , Migliorini F. , Maffulli N. , Burkhart K. J. 
Published: November 2022

Abstract
Background
Boxer elbow and handball goalkeeper elbow are causes of impingement characterized by osteophytes formation at the olecranon and coronoid tip as well as their corresponding fossae. Herein, we present another distinct pathology in these patients: the formation of an exostosis at the posterolateral aspect of the elbow.

Methods
Between April 2016 and May 2020, 12 athletes with boxer elbow and handball goalkeeper elbow (mean age of 22 years) suffering from elbow pain were enrolled in the present study. Plain radiography, magnetic resonance imaging (MRI), and computer tomography (CT) scans were used to evaluate the bone conformation of the posterolateral aspect of the elbow. Assessment and staging of the ossification was performed by two independent fellowship-trained elbow surgeons.

Results
Bone marrow edema of the posterior aspect of the elbow at the origin of the anconeus muscle was initially detected in MRI scans. With the progression of the condition, imaging revealed an ossification posterior to the capitellum with bony bridges. In the advanced stage of the disease, the exostoses was unstable as the ossification had no adherence to the posterior capitellum during surgical excision. Plain radiographs are limited in their ability to detect the condition, whereas MRI and CT scans allow to identify a signal enhancement at the posterolateral aspect of the elbow.

Conclusion
In patients without history of elbow trauma, bony irregularities of the posterior aspect of the capitellum may indicate ossification of the posterolateral aspect of the elbow, most likely caused by repetitive hyperextensions.
Castration-resistant prostate cancer cells are dependent on the high activity of CDK7
Authors: Pallasaho Satu , Gondane Aishwarya , Kuivalainen Anni , Girmay Samuel , Moestue Siver , Loda Massimo , Itkonen Harri M. 
Published: November 2022

Abstract
Purpose
Prostate cancer (PC) is successfully treated with anti-androgens; however, a significant proportion of patients develop resistance against this therapy. Anti-androgen-resistant disease (castration-resistant prostate cancer; CRPC) is currently incurable. Cyclin-dependent kinase 7 (CDK7) is positioned to positively regulate both cell cycle and transcription, the two features critical for the rapid proliferation of the CRPC cells. Here, we assess if CDK7 is a viable target to halt the proliferation of CRPC cells.

Methods
We use recently developed clinically relevant compounds targeting CDK7 and multiple cell proliferation assays to probe the importance of this kinase for the proliferation of normal, androgen-dependent, and CRPC cells. PC patient data were used to evaluate expression of CDK7 at different disease-stages. Finally, comprehensive glycoproteome-profiling was performed to evaluate CDK7 inhibitor effects on androgen-dependent and CRPC cells.

Results
We show that CDK7 is overexpressed in PC patients with poor prognosis, and that CRPC cells are highly sensitive to compounds targeting CDK7. Inhibition of O-GlcNAc transferase sensitizes the CRPC, but not androgen-dependent PC cells, to CDK7 inhibitors. Glycoproteome-profiling revealed that CDK7 inhibition induces hyper-O-GlcNAcylation of the positive transcription elongation complex (pTEFB: CDK9 and CCNT1) in the CRPC cells. Accordingly, co-targeting of CDK7 and CDK9 synergistically blocks the proliferation of the CRPC cells but does not have anti-proliferative effects in the normal prostate cells.

Conclusion
We show that CRPC cells, but not normal prostate cells, are addicted on the high activity of the key transcriptional kinases, CDK7 and CDK9.
Gefäßchirurgische Versorgung im ländlichen Raum – Anpassung an die demografischen und epidemiologischen Erfordernisse
Authors: Barth Udo , Granowski Dennis , Lehmann Martin , Meyer Frank 
Published: November 2022

Zusammenfassung
Einleitung
Die demografische Entwicklung in Deutschland und insbesondere in Sachsen-Anhalt (SA) stellt auch die Gefäßchirurgie vor Herausforderungen, denn die Inzidenz der Gefäßerkrankungen ist, dem demografischen Wandel folgend, gestiegen. So wird die Prävalenz der peripheren arteriellen Verschlusskrankheit (pAVK) in den industrialisierten Ländern bei Personen über 60 Jahren bei ca. 10–20 % geschätzt, sodass auch hier mit dem demografischen Wandel die Anzahl der Betroffenen steigen wird. Gerade im ländlichen Raum scheint es für Patienten schwieriger zu sein, eine entsprechende fachärztliche Behandlung zu erreichen.

Material und Methoden
Kompakte narrative Kurzübersicht, basierend auf selektiven Referenzen der aktuellen medizinisch-wissenschaftlichen Literatur und eigenen Erfahrungen aus der täglichen Praxis beim Aufbau einer gefäßchirurgischen Abteilung im ländlichen Raum.

Ergebnisse
Im Jahr 2020 lag die Einwohnerzahl im Landkreis Jerichower Land (SA) bei etwa 89.403 (männlich: 44.489, weiblich: 44.914). Die Altersverteilung in den für die pAVK relevanten Altersgruppen gestaltet sich derart: 65–74 Jahre – gesamt 12,38 %; ab 75 Jahre – gesamt 13,85 %; Durchschnittsalter 48,36 Jahre (Bevölkerungsdichte: 56,4/km2). Laut Kassenärztlicher Vereinigung SA kamen 2019 in Burg (SA) 605 Patienten auf einen Arzt.
Insgesamt 5087 Pflegebedürftige gab es 2019 im Landkreis. Bei so einer geringen Bevölkerungsdichte, geringer Arztdichte, hohem Altersdurchschnitt, hohem Anteil an Menschen im Alter von über 75 Jahren sowie einer hohen Anzahl an Pflegebedürftigen ist mit einer Einschränkung der Mobilität und Erreichbarkeit einer gefäßchirurgischen Versorgung zu rechnen, was sich in der hohen Anzahl an pAVK-Stadium IV (FONTAINE) in der initialen Patientenklientel widerspiegelte.
Jeder Aufbau einer gefäßchirurgischen Abteilung ist mit einer erheblichen finanziellen und materiellen Investition verbunden, die der Träger der Einrichtung bereit sein muss vorzunehmen.
Neben der materiellen Investition ist ebenfalls das Vorhandensein eines entsprechend qualifizierten Personals zur Implementierung und Aufrechterhaltung der kontinuierlichen Versorgung zu bedenken.

Schlussfolgerung
Der hohe Anteil von pAVK gefährdeten und daran leidenden Einwohnern in einem ländlich strukturierten Raum mit geringer Bevölkerungs- und Arztdichte erlaubt die Investition in die Neugründung einer gefäßchirurgischen Abteilung, um eine standortnahe Versorgung bei eingeschränkter Mobilität und Selbsthilfe in dieser Patientenklientel zu gewährleisten, damit letztlich aus angemessener gesundheitspolitischer Sicht, aber durchaus auch aus der Perspektive einer relevanten Erlösaussicht.
Evaluation of direct restorations using the revised FDI criteria: results from a reliability study
Authors: Mesinger Sabine , Heck Katrin , Crispin Alexander , Frankenberger Roland , Cadenaro Milena , Burgess John , Peschke Arnd , Heintze Siegward D. , Loomans Bas , Opdam Niek , Hickel Reinhard , Kühnisch Jan 
Published: November 2022

Abstract

Objectives

The purpose of this in vitro reliability study was to determine the intra- and inter-examiner agreement of the revised FDI criteria including the categories “fracture of material and retention” (F1) and “caries at restoration margin” (B1).

Materials and methods
Forty-nine photographs of direct tooth-coloured posterior (n = 25) and anterior (n = 24) restorations with common deficiencies were included. Ten dental experts repeated the assessment in three blinded rounds. Later, the experts re-evaluated together all photographs and agreed on a reference standard. Statistical analysis included the calculation of Cohen’s (Cκ), Fleiss’ (Fκ), and weighted Kappa (wκ), the development of a logistic regression with a backward elimination model and Bland/Altman plots.

Results
Intra- and inter-examiner reliability exhibited mostly moderate to substantial Cκ, Fκ, and wκ values for posterior restorations (e.g. Intra: F1 Cκ = 0.57, wκ = 0.74; B1 Cκ = 0.57, wκ = 0.73/Inter F1 Fκ = 0.32, wκ = 0.53; B1 Fκ = 0.41, wκ = 0.64) and anterior restorations (e.g. Intra F1 Cκ = 0.63, wκ = 0.76; B1 Cκ = 0.48, wκ = 0.68/Inter F1 Fκ = 0.42, wκ = 0.57; B1 Fκ = 0.40, wκ = 0.51). Logistic regression analyses revealed significant differences between the evaluation rounds, examiners, categories, and tooth type. Both the intra- and inter-examiner reliability increased along with the evaluation rounds. The overall agreement was higher for anterior restorations compared to posterior restorations.

Conclusions
The overall reliability of the revised FDI criteria set was found to be moderate to substantial.

Clinical relevance
If properly trained, the revised FDI criteria set are a valid tool to evaluate direct and indirect restorations in a standardized way. However, training and calibration are needed to ensure reliable application.
The project, the everyday, and reflexivity in sociotechnical agri-food assemblages: proposing a conceptual model of digitalisation
Authors: Forney Jérémie , Dwiartama Angga 
Published: November 2022

AbstractDigital technologies have opened up new perspectives in thinking about the future of food and farming. Not only do these new technologies promise to revolutionise our way of meeting global food demand, they do so by boldly claiming that they can reduce their environmental impacts. However, they also have the potential to transform the organisation of agri-food systems more fundamentally. Drawing on assemblage theory, we propose a conceptual model of digitalisation organised around three facets: digitalisation as a project; “everyday digitalisation”; and reflexive digitalisation. These facets reflect different relations between concrete practices and representations, imaginaries, and narratives, while representing different modes of agency: the collective, the distributed, and the individual, which, we argue, highlight contrasting ways for human and non-human actors to engage with digitalisation. With this model anchored in assemblage theory, we offer a tool for critically and comprehensively engaging with the complexity and multiplicity of digitalisation as a sociotechnical process. We then apply our theoretical framework to two ethnographic studies, one explores the growth of digital technologies in Switzerland as a way to govern and monitor national agriculture, the other focuses on Indonesia, where small digital startups have begun to dot the landscape. By identifying the material and semiotic processes occurring in each case, we notice similar issues being raised in terms of how digitalisation is co-constructed in society.
Ecosystem functions of fruit woody species in an urban environment
Authors: Orlandi Fabio , Marrapodi Silvia , Proietti Chiara , Ruga Luigia , Fornaciari Marco 
Published: November 2022

AbstractThe objective of this work was to investigate the potential ecosystem services of 16 fruit trees to plan and manage more efficiently “Urban Forest,” increasing also the resilience of cities to climate change. We evaluated the potential capacity of PM10 absorption, the storage of CO2 from the atmosphere, and the cooling of the environment through shading by the crown and through evapotranspiration. We observed that some species, such as Morus nigra, Juglans regia, Pyrus communis, and Cydonia oblonga, are able to store a higher quantity of CO2 than others over a period of 50 years, respectively, of 2.40 tons, 2.33 tons, 1.51 tons, and 0.96 tons. Ficus carica, Juglans regia, and Morus nigra were relevant for PM10 absorption, since they were able to absorb, referring to the year 2019, 146.4 gr/tree, 195.6 gr/tree, and 143.1 gr/tree, respectively. Results showed that these ecosystem functions depend principally on the morphological characteristics of the individuals: their height, DBH, expansion of their crowns, and characteristics of the foliage system.
Gene expression patterns associated with caudal fin shape in the cichlid Lamprologus tigripictilis
Authors: Ahi Ehsan Pashay , Richter Florian , Sefc Kristina M. 
Published: November 2022

AbstractVariation in fin shape is one of the most prominent features of morphological diversity among fish. Regulation of fin growth has mainly been studied in zebrafish, and it is not clear whether the molecular mechanisms underlying shape variation are equally diverse or rather conserved across species. In the present study, expression levels of 37 candidate genes were tested for association with fin shape in the cichlid fishLamprologus tigripictilis. The tested genes included members of a fin shape-associated gene regulatory network identified in a previous study and novel candidates selected within this study. Using both intact and regenerating fin tissue, we tested for expression differences between the elongated and the short regions of the spade-shaped caudal fin and identified 20 genes and transcription factors (includingangptl5,cd63,csrp1a,cx43,esco2,gbf1, andrbpj), whose expression patterns were consistent with a role in fin growth. Collated with available gene expression data of two other cichlid species, our study not only highlights several genes that were correlated with fin growth in all three species (e.g.,angptl5,cd63,cx43, andmmp9), but also reveals species-specific gene expression and correlation patterns, which indicate considerable divergence in the regulatory mechanisms of fin growth across cichlids.
Challenges in continuing professional development on inclusion in early years in Spain
Authors: Corral-Granados A. 
Published: November 2022

AbstractThrough a school case study, this research identifies the macro- and micro-elements that influence the continuing professional development of nursery staff in a Spanish educational setting. Organizational theories are employed to highlight the professional learning experienced by nursery staff through types of learning (formal, informal, and non-formal) and organizational learning analysis (single, double, and triple loops of learning). Qualitative data was collected through unstructured interviews, observations, and document analysis and was gathered in two sessions of three months during one academic year. This study focuses on voices from the learning communities in one early year's classroom in a state school located in Andalusia, in the south of Spain. Twelve early years staffers—including teachers, teaching assistants, managerial team, and external professionals—and six parents and 24 children were observed, including two children diagnosed with special education needs (SEN). This case study shows that a dearth of essential elements such as communication and responsibility networks, a non-permeable system, and resource management policies result in a lack of capability to offer professional development to nursery staff to meet children's educational needs.
Whole body gestational donation
Authors: Smajdor Anna 
Published: November 2022

AbstractWhole body gestational donation offers an alternative means of gestation for prospective parents who wish to have children but cannot, or prefer not to, gestate. It seems plausible that some people would be prepared to consider donating their whole bodies for gestational purposes just as some people donate parts of their bodies for organ donation. We already know that pregnancies can be successfully carried to term in brain-dead women. There is no obvious medical reason why initiating such pregnancies would not be possible. In this paper, I explore the ethics of whole-body gestational donation. I consider a number of potential counter-arguments, including the fact that such donations are not life-saving and that they may reify the female reproductive body. I suggest if we are happy to accept organ donation in general, the issues raised by whole-body gestational donation are differences of degree rather than substantive new concerns. In addition, I identify some intriguing possibilities, including the use of male bodies–perhaps thereby circumventing some potential feminist objections.
Testing drought indicators for summer burned area prediction in Italy
Authors: Vissio Gabriele , Turco Marco , Provenzale Antonello 
Published: November 2022

AbstractDuring the summer season, the Italian territory is vulnerable to extended wildfires, which can have dramatic impact on human activities and ecosystems. Such wildfire events are usually associated with the presence of drought conditions and are generally more severe in southern Italy, owing to the high temperatures and reduced precipitation that characterize this geographical region. In this work, we discuss the statistical analysis of the burned area (BA) in Italy and build simple data-driven models linking BA to different climatic drivers, comparing the relevance of direct surface soil moisture information to that provided by drought indices such as the Standardized Precipitation Index and the Standardized Precipitation Evapotranspiration Index (SPEI). We show that considering surface soil moisture alone is sufficient to produce reliable out-of-sample predictions in a large part of the country. By contrast, SPEI allows for better model performances in the more arid regions.
A primal-dual splitting algorithm for composite monotone inclusions with minimal lifting
Authors: Aragón-Artacho Francisco J. , Boţ Radu I. , Torregrosa-Belén David 
Published: November 2022

AbstractIn this work, we study resolvent splitting algorithms for solving composite monotone inclusion problems. The objective of these general problems is finding a zero in the sum of maximally monotone operators composed with linear operators. Our main contribution is establishing the first primal-dual splitting algorithm for composite monotone inclusions with minimal lifting. Specifically, the proposed scheme reduces the dimension of the product space where the underlying fixed point operator is defined, in comparison to other algorithms, without requiring additional evaluations of the resolvent operators. We prove the convergence of this new algorithm and analyze its performance in a problem arising in image deblurring and denoising. This work also contributes to the theory of resolvent splitting algorithms by extending the minimal lifting theorem recently proved by Malitsky and Tam to schemes with resolvent parameters.
Global GPBiCGstab(L) method for solving linear matrix equations
Authors: Horiuchi Itsuki , Aihara Kensuke , Suzuki Toshio , Ishiwata Emiko 
Published: November 2022

AbstractGlobal Krylov subspace methods are effective iterative solvers for large linear matrix equations. Several Lanczos-type product methods (LTPMs) for solving standard linear systems of equations have been extended to their global versions. However, the GPBiCGstab(L) method, which unifies two well-known LTPMs (i.e., BiCGstab(L) and GPBiCG methods), has been developed recently, and it has been shown that this novel method has superior convergence when compared to the conventional LTPMs. In the present study, we therefore extend the GPBiCGstab(L) method to its global version. Herein, we present not only a naive extension of the original GPBiCGstab(L) algorithm but also its alternative implementation. This variant enables the preconditioning technique to be applied stably and efficiently. Numerical experiments were performed, and the results demonstrate the effectiveness of the proposed global GPBiCGstab(L) method.
Evolutionary Approach to Biological Homochirality
Authors: Konstantinov Konstantin K. , Konstantinova Alisa F. 
Published: November 2022

AbstractWe study a very simple linear evolutionary model based on distribution of protocells by total enantiomeric excess and without any mutual inhibition and show that such model can produce two species with values of total enantiomeric excess in each of the species approaching $$\pm 1$$

±
1

when there is a global $$L\leftrightarrow D$$

L
↔
D

symmetry. We then consider a scenario when there is a small external global asymmetry factor, like weak interaction, and show that only one of the species remains in such a case, and that is the one, which is more efficient in replication. We perform an estimate of the time necessary to reach homochirality in such a model and show that reasonable assumptions lead to an estimate of around 300 thousand years plus or minus a couple of orders of magnitude. Despite this seemingly large time to reach homochirality, the model is immune to racemization because amino acids in the model follow the lifespan of the protocells rather than the time needed to reach homochirality. We show that not needing mutual inhibition in such evolutionary model is due to the difference in the topology of the spaces in which considered model and many known models of biological homochirality operate. Bifurcation-based models operate in disconnected zero-dimensional space (the space is just two points with enantiomeric excess equal $$-1$$

-
1

and $$1$$

1

), whereas considered evolutionary model (in its continuous representation) operates in one-dimensional connected space, that is the whole interval between $$-1$$

-
1

and $$1$$

1

of total enantiomeric excess. We then proceed with the analysis of the replication process in non-homochiral environment and show that replication errors (the probability to attach an amino acid of wrong chirality) result in a smooth decrease of replication time when total enantiomeric excess of the replicated structure moves away from zero. We show that this decrease in replication time is sufficient for considered model to work.