bluuebunny/crossref_metadata_2025_split huggingface dataset:
Convolution-based approach for modeling the paliperidone extended release and Long-Acting Injectable (LAI) PK of once-, and three-monthly products administration and for optimizing the development of new LAI products
Authors: Gomeni Roberto , Bressolle-Gomeni Françoise 
Published: December 2022

AbstractThe aim of this paper was to develop a convolution-based modeling approach for describing the paliperidone PK resulting from the administration of extended-release once-a-day oral dose, and once- and three monthly long-acting injectable products and to compare the performances of this approach to the traditional modeling strategy. The results of the analyses indicated that the traditional and convolution-based models showed comparable performances in the characterization of the paliperidone PK. However, the convolution-based approach showed several appealing features that justify the choice of this modeling as a preferred tool for modeling Long Acting Injectable (LAI) products and for deploying an effective model-informed drug development process. In particular, the convolution-based modeling can (a) facilitate the development of in vitro/in vivo correlation, (b) be used to identify formulations with optimal in vivo release properties, and (c) be used for optimizing the clinical benefit of a treatment by supporting the implementation of integrated models connecting in vitro and in vivo drug release, in vivo drug release to PK, and PK to PD and biomarker endpoints. A case study was presented to illustrate the benefits and the flexibility of the convolution-based modeling outcomes. The model was used to evaluate the in vivo drug release properties associated with a hypothetical once-a-year administration of a LAI product with the assumption that the expected paliperidone exposure during a 3-year treatment overlays the exposure expected after repeated administrations of a 3-month LAI product.
Interhemispheric Integration after Callosotomy: A Meta-Analysis of Poffenberger and Redundant-Target Paradigms
Authors: Westerhausen René 
Published: December 2022

AbstractThe central role of the corpus callosum in integrating perception and cognition across the cerebral hemispheres makes it highly desirable for clinical and basic research to have a repertoire of experimental paradigms assessing callosal functioning. Here, the objective was to assess the validity of two such paradigms (Poffenberger, redundant-target paradigms) by conducting single-step meta-analyses on individual case data of callosotomy patients. Studies were identified by systematic literature search (source: Pubmed and WebOfKnowledge, date: 07.03.2022) and all studies were included that reported callosotomy case data for either paradigm. Twenty-two studies (38 unique cases) provided 116 observations of the crossed-uncrossed difference (CUD) for the Poffenberger paradigm, while ten studies (22 cases, 103 observations) provided bilateral redundancy gain (bRG) measures. Using linear-mixed models with “individual” and “experiment” as random-effects variable, the mean CUD was estimated at 60.6 ms (CI95%: 45.3; 75.9) for commissurotomy, 43.5 ms (26.7; 60.2) for complete callosotomy, and 8.8 ms (1.1; 16.6) for partial anterior-medial callosotomy patients. The estimates of commissurotomy/callosotomy patients differed significantly from patients with partial callosotomy and healthy controls. The mean bRGmin (minimum unilateral reference) was estimated at 42.8 ms (27.1;58.4) for patients with complete and 30.8 ms (16.8; 44.7) for patients with partial callosotomy, both differing significantly from controls. One limitation was that different formulas for bRG were used, making it necessary to split the sample and reducing test power of some analyses. Nevertheless, the present findings suggest that both paradigms assess interhemispheric callosal integration, confirming their construct validity, but likely test distinct callosal functions.
Intuitive teaching of medical device operation to clinical assistance robots
Authors: Baumann Oskar , Lenz Alexander , Hartl Josef , Bernhard Lukas , Knoll Alois Christian 
Published: December 2022

Abstract
Purpose:
The adjustment of medical devices in the operating room is currently done by the circulating nurses. As digital interfaces for the devices are not foreseeable in the near future and to incorporate legacy devices, the robotic operation of medical devices is an open topic.

Methods:
We propose a teleoperated learning from demonstration process to acquire the high-level device functionality with given motion primitives. The proposed system is validated using an insufflator as an exemplary medical device.

Results:
At the beginning of the proposed learning period, the teacher annotates the user interface to obtain the outline of the medical device. During the demonstrated interactions, the system observes the state change of the device to generalize logical rules describing the internal functionality. The combination of the internal logics with the interface annotations enable the robotic system to adjust the medical device autonomously. To interact with the device, a robotic manipulator with a finger-like end-effector is used while relying on haptic feedback from torque sensors.

Conclusion:
The proposed approach is a first step towards teaching a robotic system to operate medical devices. We aim at validating the system in an extensive user study with clinical personnel. The logical rule generalization and the logical rule inference based on computer vision methods will be focused in the future.
Potential of seagrass habitat restorations as nature-based solutions: Practical and scientific implications in Indonesia
Authors: Rifai Husen , Quevedo Jay Mar D. , Lukman Kevin Muhamad , Sondak Calyvn F. A. , Risandi Johan , Hernawan Udhi Eko , Uchiyama Yuta , Ambo-Rappe Rohani , Kohsaka Ryo 
Published: December 2022

AbstractSeagrasses offer diverse ecosystem services, yet, they are among the most threatened ecosystems. When degraded or destroyed, their services are lost or reduced in the process, affecting, for instance, local communities directly dependent on their livelihood provision. The Intergovernmental Panel on Climate Change (IPCC) reported that climate change is projected to worsen over time; thus, there is an urgent need for mitigation strategies in practice and also in the longer term. This work aims to provide an alternative perspective of seagrass restoration as a nature based solution (NbS) on a global scale, yet, giving an emphasis on tropical regions such as Indonesia. We focused on seagrass restorations which are not yet well established in comparison with other restoration programs (e.g., mangroves) despite their critical roles. We present in this work how restoring seagrass meadows fits the global standard of NbS published by the International Union for Conservation of Nature (IUCN). The results of this study can serve as a basis for promoting seagrass restorations as NbS against climate change particularly in countries with a wide extent of seagrass coverage.
Medical Students and the Impostor Phenomenon: A Coexistence Precipitated and Perpetuated by the Educational Environment?
Authors: Franchi Thomas , Russell-Sewell Nigel 
Published: December 2022

AbstractPeople who experience the impostor phenomenon have intense thoughts of fraudulence regarding their intellect or professional activities. This perception of illegitimacy leads sufferers to believe that success in their lives is attributable to some form of error. Despite the phenomenon having been thoroughly researched in a plethora of professional and educational environments, there remains a relative lack of insight into the impostor phenomenon amongst medical students. This research aimed to better understand the relationship between medical students and the impostor phenomenon, and subsequently to investigate whether their coexistence is precipitated and perpetuated by the educational environment. A cross-sectional study of medical students was conducted using a pragmatist approach, integrating quantitative and qualitative data, via a questionnaire, focus groups and interviews. The main quantitative measure used was the validated Clance Impostor Phenomenon Scale (CIPS), where higher scores indicate more marked impostor experiences. A total of 191 questionnaire responses were received, and 19 students attended a focus group or interview. The average CIPS score for the cohort was 65.81 ± 13.72, indicating that the average student had “frequent” impostor experiences. Of note, 65.4% of students were classed as having “clinically significant” impostor experiences and females scored 9.15 points higher than males on average (p < 0.0001). Examination rankings were frequently cited as a major contributing factor to students’ impostor feelings, and data revealed an increase of 1.12 points per decile that a student drops down the rankings (p < 0.05). Students’ quotes were used extensively to underpin the quantitative data presented and offer an authentic insight into their experiences. This study provides new insights and contributes to our understanding of the impostor phenomenon amongst medical students, and eight recommendations for practice are presented, which are intended to provide medical schools with opportunities for pedagogical innovation.
Numerical and experimental investigation of the geometry dependent layer-wise evolution of temperature during laser powder bed fusion of Ti–6Al–4V
Authors: Li Gefei , Ganeriwala Rishi , Herzog Dirk , Bartsch Katharina , King Wayne 
Published: December 2022

AbstractLaser powder bed fusion (L-PBF) is currently the additive manufacturing process with the widest industrial use for metal parts. Yet some hurdles persist on the way to a widespread industrial serial production, with reproducibility of the process and the resulting part properties being a major concern. As the geometry changes, so do the local boundary conditions for heat dissipation. Consequently, the use of global, geometry-independent processing parameters, which are today’s state of the art, may result in varying part properties or even defects. This paper presents a numerical simulation as a method to predict the geometry-dependent temperature evolution during the build. For demonstration, an overhang structure with varying angles towards the build platform was manufactured using Ti–6Al–4V. A calibrated infrared camera was integrated into a commercial L-PBF system to measure the temperature evolution over time for a total build height of 10 mm, and the results are used for validation of the simulation. It is shown that the simulation is capable of predicting the temperature between layers. The deviations between simulation and measurement remain in single digit range for smaller overhang structures (90°, 60° and 45°). For large overhang structures (30°), the simulation tends to over-predict the temperatures up to 15 °C. Experiments with varying process parameters showed the feasibility of energy reduction as compensation of the heat accumulation produced by overhang structures.
Chemical Profiling of Citrus sinensis Root and the Effects of Its Secondary Metabolites on Cisplatin-Induced Renal and Cardiac Toxicities
Authors: Hamdan Dalia I. , Attia Rasha A. , Nael Manal A. , Mahmoud Mona F. , El-Shazly Assem M. 
Published: December 2022

AbstractCitrus fruits are among the most important economical crops, because of their nutritional value, medicinal importance, and unique flavor. Gas liquid chromatography-mass spectrometry of the hydro-distilled oil from the root resulted in the identification of 110 compounds with germacrene B (22%), aromadendrene (21.6%), α-santalene (7.1%), geijerene (4,81%), germacrene D (4.3%), and limonene (3.4%) as major constituents. In addition, chemical profiling the dichloromethane fraction of the root analyzed by high-performance liquid chromatography-photo diode array detector-electrospray tandem mass spectrometry afforded the identification of 43 compounds belonging to acridone alkaloids, coumarins, and flavonoids. Moreover, xanthyletin, citracridone I and II, clausarin, O-methylcitrusinine-I, and grandisinine were isolated as major metabolites using column chromatography and characterized depending on different spectroscopic techniques. Xanthyletin and citracridone I were investigated for their in vitro cytotoxicity against hepatocellular carcinoma and breast adenocarcinoma cell lines, and in vivo protective effect against cisplatin-induced nephrotoxicity and cardiotoxicity in different dose levels in a rat model. Xanthyletin and citracridone I showed protective activity against cisplatin-induced nephrotoxicity. It attenuated cisplatin-induced elevation of both serum urea and creatinine in a dose-dependent manner. Moreover, xanthyletin attenuated cisplatin-induced elevation of malondialdehyde and glutathione in both renal and cardiac tissues.
Graphical abstract
Complex Berry curvature and complex energy band structures in non-Hermitian graphene model
Authors: Wu Chao , Fan Annan , Liang Shi-Dong 
Published: December 2022

AbstractNon-Hermitian quantum systems exhibit many novel physical properties of quantum states. We consider a non-Hermtian graphene model based on the tight-binding approximation with the coupling of the graphene and the substrate. We analyze the complex energy structure of this model and its exceptional points as well as relevant topological invariants. We give the analytic complex Berry connection and Berry curvature in the Brillouin zone and investigate numerically the relationships between the complex Berry curvature and the complex energy band structures. We find that the behaviors of the complex Berry curvature depend on the complex energy band structures. The occurrence of the peaks of both real and imaginary parts of the complex Berry curvature corresponds to the exceptional (gapless) points in the Brillouin zone. In particular, the Dirac cone of the imaginary part of the Berry curvature occurs and corresponding to the occurrence of the flat real energy band for the non-Hermitian parameter $$\eta =3$$

η
=
3

. These results provide some novel insights to the relationship between the non-Hermitian graphene, geometry, and topological invariants.
Alpha Power Transformed Extended power Lindley Distribution
Authors: Eissa Fatehi Yahya , Sonar Chhaya Dhanraj 
Published: December 2022

AbstractThe Lindley distribution has been generalized by several researchers in recent years. In this paper, we introduce and study a new generalization of extended power Lindley distribution named alpha power transformed extended power Lindley (APTEPL) distribution that provides better fits than the extended Power Lindley distribution and existing generalizations. It includes the alpha power transformed power Lindley, alpha power transformed extended Lindley, alpha power transformed Lindley, extended power Lindley, power Lindley, extended Lindley and Lindley distribution as a special cases. In this article various properties of the APTEPL distribution such as moments, moment generating function, Characteristic function and cumulant generating function, quantiles and Order Statistics are derived. Method of maximum likelihood estimation is used to obtain the model parameters. A simulation study is performed to examine the performance of the maximum likelihood estimators of the parameters. Two data sets have been utilized to show how the APTEPL distribution works in practice.
Making the APPropriate choice: Utilization of a smartphone application to optimize antimicrobial decisions among internal medicine trainees
Authors: Brooke Thomas R. , Pfaeffle Herman O. , Guillory Walter O. , Raiciulescu Sorana , Ressner Roseanne A. 
Published: December 2022

Abstract
Utilization of a smart phone application paired with a time-spaced learning curriculum was investigated to determine its impact on antimicrobial stewardship practice among internal medicine trainees. Stewardship behaviors increased, barriers decreased, and trainees had increased confidence in managing common infectious disease syndromes after the intervention.
COVID-19-related mental health difficulties among marginalised populations: A literature review
Authors: Camara Chaka , Surkan Pamela J. , Van Der Waerden Judith , Tortelli Andrea , Downes Naomi , Vuillermoz Cécile , Melchior Maria 
Published: December 2022

Abstract
The COVID-19 pandemic has had negative consequences on the mental health of the population, which has been documented. Marginalised groups that are at risk of poor mental health overall have been particularly impacted. The purpose of this review is to describe the mental health impact of the COVID-19 pandemic on marginalised group (i.e. persons who are socio-economically disadvantaged, migrants and members of ethno-racial minorities, experience homelessness) and identified interventions which could be well-suited to prevent and address mental health difficulties. We conducted a literature review of systematic reviews on mental health difficulties since the beginning of the COVID-19 epidemic and appropriate interventions among marginalised groups published from January 1, 2020 to May 2, 2022, using Google Scholar and PubMed (MEDLINE). Among 792 studies on mental health difficulties among members of marginalised groups identified by keywords, 17 studies met our eligibility criteria. Twelve systematic reviews examining mental health difficulties in one or several marginalised groups during the COVID-19 pandemic and five systematic reviews on interventions that can mitigate the mental health impact of the COVID-19 pandemic were retained in our literature review. The mental health of marginalised groups was severely affected during the COVID-19 pandemic. Most frequently reported mental health difficulties included symptoms of anxiety and depression. Additionally, there are interventions that appear effective and well-suited for marginalised populations, which should be disseminated on a large scale to mitigate the psychiatric burden in these groups and at the population level.
On the splitting and aggregating of Hawkes processes
Authors: Li Bo , Pang Guodong 
Published: December 2022

AbstractWe consider the random splitting and aggregating of Hawkes processes. We present the random splitting schemes using the direct approach for counting processes, as well as the immigration–birth branching representations of Hawkes processes. From the second scheme, it is shown that random split Hawkes processes are again Hawkes. We discuss functional central limit theorems (FCLTs) for the scaled split processes from the different schemes. On the other hand, aggregating multivariate Hawkes processes may not necessarily be Hawkes. We identify a necessary and sufficient condition for the aggregated process to be Hawkes. We prove an FCLT for a multivariate Hawkes process under a random splitting and then aggregating scheme (under certain conditions, transforming into a Hawkes process of a different dimension).
Longitudinal relations among family dysfunction, depressive symptoms, and cyberbullying involvement in Chinese early adolescents: Disentangling between- and within-person associations
Authors: Zhou Jianhua , Li Xiang , Zou Yan , Gong Xue 
Published: December 2022

AbstractFamily dysfunction plays an important role in cyberbullying and cybervictimization. However, little research has investigated the longitudinal relations and the mediating mechanisms between them during adolescence. This study examined the longitudinal relations between family dysfunction and cyberbullying and cybervictimization, along with whether depressive symptoms function as mediators between them at the within-person level. A total of 3,743 Chinese adolescents (46.2% females; Mage = 9.92 years; SD = 0.51) participated a five-wave longitudinal study with a 6-month time interval. The results of random intercept cross-lagged panel model found that: (1) family dysfunction directly predicted depressive symptoms and vice versa at the within-person level; (2) depressive symptoms directly predicted cyberbullying and cybervictimization at the within-person level, but not vice versa; (3) family dysfunction indirectly predicted cyberbullying and cybervictimization via depressive symptoms at the within-person level; (4) at the between-person level, there were significant associations among family dysfunction, depressive symptoms, cyberbullying and cybervictimization. The results are discussed on the basis of the mechanisms that lead to cyberbullying and cybervictimization.
The Operatic Roots of Performativity: Bodies Decontextualised in Butler, Brecht and Busoni
Authors: Collins Sarah 
Published: December 2022

AbstractIt has long been claimed that opera can give expression to the uneasy relationship between the body and the voice. Operatic voices seem to exceed the capacity of the bodies that produce them in a way that conveys a sense of mechanisation or limited agency, inviting metaphorical comparisons to marionettes. Yet recent studies of gesture have suggested that bodies are not simply passively inscribed with meaning but that they also mediate the process of inscription. Investigating the implications of this claim for opera, this article discusses two recent essays by Judith Butler, in which she draws from Walter Benjamin's account of gesture in Brecht's epic theatre to argue for the performative power of incomplete or decontextualised bodily actions. It then traces this idea to a moment in epic theatre's own prehistory, focusing on Ferruccio Busoni's opera Doktor Faust. The article makes both a theoretical point and an historical claim: it highlights how bodies and words that are decontextualised can perform a critical function despite not enjoying the usual citational supports necessary for a speech act; and it argues that Busoni's Doktor Faust and his theory of opera were a part of the intellectual prehistory to Butler's conceptualisation of bodily performativity.
Future directions in rural history: Ireland, the First World War and the search for historical evidence
Authors: Destenay Emmanuel 
Published: December 2022

AbstractA social history of Ireland (encompassing rural communities) is needed if historians are to fully come to terms with what really happened between 1914 and 1918 and to properly tackle the question of ‘consent’ and ‘constraint’ in relation to the war effort. In addition, historians need to devote a comprehensive book-length research to the April 1918 Conscription Crisis in Ulster (but more generally to the anti-conscription movement in Ulster), determining if the urban/rural – Belfast/countryside divide existed (and, if so, what its magnitude was). Finally, in a few years’ time, anyone will be able to say if the Republic of Ireland of today opted to anchor the global conflict in the collective memory of its people, or if the Centenary of the First World War was just a politically motivated parenthesis to commemorate a lost generation that still struggles to find its rightful place in modern Irish history.