bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short- and long-term outcomes of preservation of the superior rectal artery versus ligation of the inferior mesenteric artery in laparoscopic D3 lymph node dissection for descending colon cancer: a propensity score-matched analysis
Authors: Sato Aya , Imaizumi Ken , Kasajima Hiroyuki , Ichimura Kentaro , Sato Kentaro , Yamana Daisuke , Tsuruga Yosuke , Umehara Minoru , Kurushima Michihiro , Nakanishi Kazuaki 
Published: September 2022

Abstract
Purpose
This study aimed to compare the short- and long-term outcomes of laparoscopic D3 lymph node (LN) dissection between ligation of the inferior mesenteric artery (IMA) (LIMA) and preservation of the superior rectal artery (SRA) (PSRA) for descending colon cancer using propensity score-matched analysis.
Methods
This retrospective study included 101 patients with stage I-III descending colon cancer who underwent laparoscopic D3 LN dissection with LIMA (n = 60) or PSRA (n = 41) at a single center between January 2005 and March 2022. After propensity score matching, 64 patients (LIMA, n = 32; PSRA, n = 32) were included in the analysis. The primary endpoint was the long-term outcomes, and the secondary endpoint was the surgical outcomes.
Results
In the matched cohort, no significant difference was noted in surgical outcomes, included the operative time, estimated blood loss, number of harvested LNs, number of harvested LN 253, and complication rate. The long-term outcomes were also not significantly different between the LIMA and PSRA groups (3-year recurrence-free survival: 78.7% vs. 88.9%, P = 0.335; 5-year overall survival: 69.8% vs. 63.4%, P = 0.888; 5-year cancer-specific survival: 84.2% vs. 82.8%, P = 0.607). No recurrence of LN metastasis was observed around the IMA root.
Conclusion
Laparoscopic D3 dissection in PSRA was comparable to that in LIMA regarding both short- and long-term outcomes. The optimal LN dissection for descending colon cancer should be investigated in future large-scale studies.
Health-related quality of life and associations on socio-demographic and clinical factors in schizophrenia based on the QLICD-SC scale: A cross-sectional study
Authors: Rao Shuying , Liu Yuxi , Xian Junding , Lin Zhixiong , Wang Dandan , Xue Benli , Wan Chonghua 
Published: September 2022

Abstract
Purpose
This paper aimed at providing evidence for developing countermeasures to improve patients’ quality of life by using the scale Quality of Life Instruments for Chronic Diseases-Schizophrenia (V2.0)(QLICD-SC)), which is modular and sensitivity.
Methods
163 people who met the diagnostic criteria for schizophrenia of the International Classification of Diseases(10th Revision) and were hospitalized at the Affiliated Hospital of Guangdong Medical University from May 2014 to December, 2015 were selected. Patients' clinical objective indexes, including blood routine, urine routine, blood biochemical examination, blood gas analysis etc. were collected by reviewing the medical records. Patients were assessed by the QLICD-SC (V2.0), a quality of life measurement scale for Schizophrenia. Simple correlation analysis was used to explore the correlation between the QLICD-SC (V2.0) scores and various clinical objective indicators, and multiple linear regression was used to further screen for correlates.
Results
There were 163 participants, ranging in age from 16 to 69, with a 30.67 ± 11.44 average age. The majority of them were men(57.1%), had a high school diploma(77.9%), and were married (65.6%). According to multiple linear regression, the variables included in the model are education, sex, eosinophilic granulocyte, hematocrit, percentage of monocytes, phosphorus (R2 = 0.065 ~ 0.222, P < 0.05).
Conclusion
Some clinical indicators such as hematocrit and socio-demographic factors may reflect alterations in the quality of life of individuals with schizophrenia.
Higher serum uric acid with a high eGFR is associated with decreased risk of low muscle strength in aged population: a retrospective cohort study
Authors: Huang Yu Cheng , Chen Si Liang , Dong Ying , Shi Ying 
Published: September 2022

Abstract
Background
We aimed to investigate the interaction between serum uric acid levels with estimated glomerular filtration rate (eGFR) to low muscle strength (LMS) in a large Chinese elderly population.
Methods
Cohort data were obtained from China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2015. Two thousand seven hundred forty-five community-dwelling older participants were enrolled for the follow-up. Serum uric acid was collected after 8 hours of fasting, and handgrip strength was measured with a dynamometer. eGFR was calculated with an equation based on the Chinese population. A generalized additive model was employed for interaction analysis and progressively adjusted confounders.
Results
In this study, we found that men with a low eGFR (<60 mL/min/1.73 m2) reported higher SUA levels (5.91 ± 1.27) and older (72.53 ± 6.38) than those who had a high eGFR while women share the same difference with a lower eGFR in higher SUA levels (5.00 ± 1.34) and older (72.81 ± 6.83). After progressively adjusting covariates, in females, the OR for higher eGFR with higher SUA level remained significantly with low muscle strength (OR=0.80 95%CI=0.68-0.95 P=0.0102). This correlation, however, was not observed in men.
Conclusions
This population-based cohort study in Chinese revealed that high serum uric acid level with higher eGFR seems to be significantly associated with a lower risk of low muscle strength in the elderly, especially in females.
Treatment burden for older people with multimorbidity: a cross-sectional study in China
Authors: Dou Liyuan , Jiang Qiuling , Duncan Polly , Li Xiaoping 
Published: September 2022

Abstract
Background
There has been little research in China about treatment burden. Studies internationally have found high treatment burden is associated with number of long-term conditions, low quality of life (QoL) iand poor medication adherence. The purpose of this study is to understand factors associated with high treatment burden for older people with multimorbidity in China.
Methods
A cross-sectional survey was conducted from February to May 2022. Through convenience sampling, 353 older people (≥ 60 years) with multimorbidity (≥ 2 long-term conditions) admitted to hospital in Zhengzhou, China, were invited to complete a survey including sociodemographic characteristics, long-term conditions and the Chinese version of Multimorbidity Treatment Burden Questionnaire (C-MTBQ). Ordinal logistic regression was used to identify the factors associated with high treatment burden.
Results
342 older people with multimorbidity participated (response rate 92.2%) among whom, the prevalence of no, low, medium, and high treatment burden was 1.2% (4/342), 13.9% (44/342), 49.1% (168/342), and 36.8% (126/342), respectively. Ordinal logistic regression analysis found high treatment burden was associated with age, monthly household income, type of medical insurance, and number of long-term conditions.
Conclusion
Most surveyed older people with multimorbidity experienced medium-to-high treatment burden. Policy makers and service providers should focus particularly on people at risk of higher treatment burden, namely older people with low income, New Rural Cooperative and high number of long-term conditions. Policy should be addressed to reduce health inequalities from different types of medical insurance.
Relationship and mechanism of gut microbiota and susceptibility to type 2 diabetes mellitus
Authors: An Yongcheng , Dai Hongyu , Duan Yuhui , Cheng Long , Shi Lu , He Changhao , Wang Chen , Lv YingLan , Li Huimin , Zhang Huilin , Huang Yan , Fu Wangxin , Sun Weiguang , Zhao Baosheng 
Published: September 2022

Abstract
Purpose
To investigate the relationship between the susceptibility to type 2 diabetes and gut microbiota and explore the potential mechanisms.
Methods
Thirty-two SPF SD rats were raised as the donor rats, and divided into control, type 2 diabetes mellitus (T2DM) and Un-mod groups. Feces were collected and prepared as fecal bacteria supernatant A (T2DM group), B (Un-mod group) and Con (control group). Another seventy-nine SPF SD rats were separated into normal saline (NS) and ABX groups. ABX and NS groups were given antibiotics solution and normal saline, respectively. And then, the ABX group were randomly separated into the ABX1 (4-weeks ordinary diet), ABX2 (4-weeks HFD and STZ ip), FMT-A (fecal microbiota A transplantation, 4-weeks HFD and STZ ip), FMT-B (fecal microbiota B transplantation, 4-weeks HFD and STZ ip) and FMT-Con (normal fecal microbiota transplantation, 4-weeks HFD and STZ ip) groups. The NS group were randomly divided into the NS1 (4-weeks ordinary diet) and NS2 (4-weeks HFD and STZ ip) groups. The short-chain fatty acids (SCFAs) in feces were detected by gas chromatography using 16S rRNA gene sequencing. G protein-coupled receptor 41 (GPR41) and GPR43 were detected by Western blot and quantitative real-time polymerase chain reaction.
Results
g__Ruminococcus_gnavus_group were increased obviously in the FMT-A group (vs ABX2 or FMT-B group). Blood glucose levels, serum insulin, total cholesterol levels, triglyceride levels, and low-density lipoprotein cholesterol levels were evidently increased in the FMT-A group than ABX1 or ABX2 group. It was found that both the FMT-A and FMT-B groups had evidently higher contents of acetic acid and butyric acid (vs ABX2 group). In both FMT-A and FMT-B groups, GPR41 protein expression and GPR43 mRNA and protein expression increased.
Conclusions
G__Ruminococcus_gnavus_group may cause T2DM susceptibility, and T2DM susceptible flora transplantation can evidently increase the susceptibility to T2DM. It is possible that gut microbiota-SCFAs-GPR41/GPR43 play a role in the development of T2DM. A new treatment strategies and methods may be to develop pharmaceutical treatments that reduce blood glucose by controlling gut microbiota.
Evaluation and prediction of irrigation water quality of an agricultural district, SE Nigeria: an integrated heuristic GIS-based and machine learning approach
Authors: Omeka Michael Ekuru 
Published: September 2022

Abstract

Poor irrigation water quality can mar agricultural productivity. Appraising the irrigation water quality requires the computation of various conventional quality parameters which are often time-consuming and associated with errors during sub-index computation. It becomes critical therefore, to have a visual assessment of the irrigation water quality and identify the most influential water quality parameters for accurate prediction, management, and sustainability of irrigation water quality. The overlay weighted sum technique was used to generate the irrigation water quality (IWQ) map of the area. The map revealed that 72.5% of the area (within the southeastern parts) were suitable for irrigation while 28.4% (found in isolated traces) were unsuitable. Multilayer perceptron artificial neural networks (MLP-ANNs) and multiple linear regression models (MLR) were integrated and validated to predict the IWQ parameters using Cl−, HCO3−SO42−, NO3−, Ca2+, Mg2+, Na+, K+, pH, EC, TH and TDS as input variables, and PI, MAR, SAR, PI, KR, SSP, and PS as output variables. The two models showed high performance accuracy based on the results of the coefficient of determination (R2 = 0.513–0.983). Low modeling errors were observed from results of the sum of square errors (SOSE), relative errors (RE), adjusted R-square (R2adj), and residual plots; further confirming the efficacy of the two models, although the MLP-ANNs showed higher prediction accuracy with respect toR2. Based on the sensitivity of the MLP-ANN model, HCO3, pH, SO4, EC, and Cl were identified to have the greatest influence on the irrigation water quality of the area. This study has shown that the integration of GIS and Machine Learning can serve as rapid decision tools for proper planning and enhanced agricultural productivity.
Groundwater chemistry and health hazard risk valuation of fluoride and nitrate enhanced groundwater from a semi-urban region of South India
Authors: Dhakate Ratnakar , More Shekhar , Duvva Laxman Kumar , Enjamuri Satyanarayana 
Published: September 2022

Abstract
Valuation of groundwater chemistry and its related health hazards risk for humans is a prerequisite remedial measure for human health. The semi-urban region in southern India was selected to measure the groundwater quality and interpret the human health risk valuation with deference to different age groups of adults and children through oral intake and skin contact of elevated concentration of fluoride (F−) and nitrate (NO3−) water in the absence of other alternatives. Water samples were collected from the semi-urban region for pre and post rainfall period and resolute its chemistry. However, F− concentration ranges 0.28 - to 5.48 mgL− and 0.21–4.43 mgL−; and NO3− concentration ranges 0.09 - to 897.28 mgL− and 0.0 - to 606.10 mgL− elevating the drinking standars of F− in 32% and 38% samples and of NO3− in 62% and 38% during pre and post rainfall seasons respectively. The fluoride-bearing minerals are the main sources of elevated concentration of F− and excessive use of nitrate fertilizers as the chief source of NO3− concentration in the aquifer regime. Water Quality Index (WQI) ranged from 18.3–233 and 12.97-219.14; 20% and 22% showed poor water quality for pre and post rainfall seasons with WQI = > 200. Piper plot suggests that 46% and 51% of samples signify carbonate water type (Ca2+- HCO\(_{3}^{ - }\)), and 32% and 28% of groundwater samples show Ca2+ + Na++ HCO3− type water for pre and post rainfall seasons respectively. Gibb's plot suggests the dominance of water-rock interaction in the aquifer system. Further, the principal component analysis (PCA) supported the same factors contributing to the elevated concentration of F− and NO3− in groundwater. The hazard quotient (HQ) through ingestion (HQing) and dermal (HQder) pathways of F− and NO3− was observed higher than its acceptable limit of 1.0 for different age groups indicating the non-carcinogenic effect on human health and effective strategic measures to be implemented in the area for improvement of human health conditions.
IFI30 Modulates Immune Microenvironment And Improves Prognosis In Glioblastoma
Authors: Huang Jianhuang , You Guiting , Song Jianhua , Xue Liang , Lin Caihou 
Published: September 2022

Abstract
Background
Immunotherapy has brought new hope as a potentially effective treatment for Glioblastoma (GBM).It is currently considered that an effective T cell immune strategy should improve antigen presentation and recognition and block T cell exhaustion. The main function of γ-interferon-inducible lysosomal thiol reductase (IFI30) is to promote antigen processing and presentation and enhance the anti-tumor effect of cytotoxic lymphocyte (CTL). However, the exact function of IFI30 in GBM development and progression is not yet known.
Methods
We used multiple public databases to explore the DNA methylation, mRNA transcription and protein expression of IFI30 in GBM, and tried to use the DNA methylation detection data of three cases of GBM to verify the above results. Subsequently, we analyzed the relationship between IFI30, WHO grade and GBM subtype, and studied the diagnostic and prognostic value of IFI30. Further, we combined with public databases to analyze the relationship between IFI30 and immune cell infiltration and immune checkpoints. Finally, we made functional predictions for IFI30 in GBM.
Results
In GBM, the mRNA transcription level and protein expression level of IFI30 were significantly higher than those in normal tissues. Although the methylation level of IFI30 promoter was decreased, it was significantly increased at local sites. We confirmed the above conclusion after analyzing the DNA methylation detection data of 3 cases of GBM, and found that cg26152923, cg07533630, and cg01485548 were the key prognostic loci after cross-validation. Subsequently, we found that IFI30 was strongly associated with higher WHO grade, MES subtype, and recurrence status of gliomas. At the same time, IFI30 also showed good diagnostic value (AUC = 0.987) and prognostic value. Further, we also found that IFI30 is positively correlated with CD8+ T cells, Treg and other immune cells, and also positively correlated with PD-1, CTLA-4 and other immune checkpoints. Finally, we found that IFI30 may function through Treg development, PPAR signaling pathway, Toll-like receptor signaling pathway and other mechanisms.
Conclusions
IFI30 could be an ideal diagnostic and prognostic biomarker and therapeutic target for GBM.
Alpha-crystallins protect photoreceptors during retinal detachment through FAIM2 regulation
Authors: Besirli Cagri G. , Nath Madhu , Yao Jingyu , Pawar Mercy , Myers Angela M. , Zacks David , Fort Patrice E. 
Published: September 2022

Abstract
We evaluated the role of α-crystallin in photoreceptor survival in an experimental model of retinal detachment, and its association with Fas apoptosis inhibitory molecule 2 (FAIM2). Retina/RPE separation was induced in rat and mouse eyes by the subretinal injection of hyaluronic acid, 1%. Retinal tissues were analyzed for the presence αA-crystallin and αB-crystallin proteins using immunohistochemistry and immunoblot. Indices of photoreceptor death were analyzed using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) staining and cell counts. The 661W cells subjected to FasL were used as a cell model of photoreceptor degeneration to assess the mechanisms of the protective effect of αA-crystallin and its phosphorylation on T148. In addition to the associated cell-death, FAIM2 and αA-crystallin interaction were evaluated using co-immunoprecipitation assay. α-Crystallin protein levels were rapidly induced in response to retinal detachment, with αA-crystallin playing a particularly important role in protecting photoreceptors during retinal detachment. Our data also shows that FAIM2, an intrinsic neuroprotective protein in photoreceptors, interacts with α-crystallins following retinal detachment. Mechanistically, our work also demonstrated that the phosphorylation of αA-crystallin is essential for the interaction of αA-crystallin with FAIM2 and their neuroprotective effect. Thus, αA-crystallin is involved in the regulation of photoreceptor survival during retinal detachment, playing a key role in the stabilization of FAIM2, an important modulator of photoreceptor cell survival under chronic stress condition.
The impact of working in COVID-19 hospital on mental health and wellbeing: A qualitative study with nurses in a hospital in East Nusa Tenggara, Indonesia
Authors: Asa Gregorius Abanit , Fauk Nelsensius Klau , Ratu Melkianus , Ward Paul Russell 
Published: September 2022

Abstract
Background
The outbreak of coronavirus disease (COVID-19) has impacted the lives of more than 580 million people worldwide and killed more than six million people globally. Nurses are one of the most impacted groups as they are at the frontline to fight against the virus and to save the life of everyone affected. The present study aimed to explore the impact of working in COVID-19 wards on mental health and wellbeing of nurses in the early stage of the pandemic in a hospital, in East Nusa Tenggara, Indonesia.
Methods
A qualitative study was conducted with 22 nurses. They were recruited using the purposive sampling technique. Data collection was conducted from April to May 2022 and data analysis was guided by a qualitative framework analysis.
Results
The findings show that nurses experienced a range of mental health impacts including fear of being infected and infecting loved ones; fear of early death; psychological distress related to the conflict between the lack of personal protective equipment (PPE) and professionality and moral responsibility for patients; stress and worry due to public indifference and lack of role models; the negative impact of community doubt and distrust around COVID-19; and distress due to stigma and discrimination towards nurses caring for COVID-19 patients and their families.
Conclusions
The current findings indicate further psychological intervention programs to support nurses, especially the ones in resource poor settings and enhance their psychological resilience.
Global practical potential for metal–organic frameworks assisted atmosphere water harvesting
Authors: Wang Jiayun , Ying Wenjun , Hua Lingji , Zhang Hua , Wang Ruzhu 
Published: September 2022

Abstract
Nowadays, freshwater shortage remains a global challenge. Sorbent-assisted atmospheric water harvesting (SAWH) is a promising strategy for extracting atmospheric moisture to provide arid regions with potable water. As appropriate sorbents are crucial for efficient SAWH, many novel sorbents have been emerging in recent years. However, the lack of efficiency benchmarks prevents accurate evaluation of sorbents’ practical potential in SAWH system, thereby hindering location- and climate-specific sorbent selection. Herein, reliable models were established to analyze the global SAWH potential of metal–organic frameworks (MOFs) in terms of practical water yields and energy requirements for passive and active SAWH respectively. Moreover, geospatial guidance of the efficient MOFs-assisted AWH deployment was provided based on a thermodynamic framework in combination with high-resolution global weather data throughout a year with seasonal climate variation. Applicable sorbent-assisted water harvesting strategies were then developed for six water-scarce regions. Overall, this study established benchmarks for location- and climate-specific adsorbents that will expand the application of sorbent-assisted water harvesting technologies in effective off-grid water-supply systems in water-scarce regions.
Transition of antimicrobial resistome in wastewater treatment plants: impact of process configuration, geographical location and season
Authors: Honda Ryo , Matsuura Norihisa , Hara-Yamamura Hiroe , Sorn Sovannlaksmy , Morinaga Yuta , Than Van Huy , Sabar Muhammad Adnan , Masakke Yalkhin , Asakura Sawako , Watanabe Toru 
Published: September 2022

Abstract
Wastewater is the major source of the emergence of antimicrobial resistance (AMR) in water environment. Wastewater treatment plants (WWTPs) are the important barriers for preventing the spread of AMR in wastewater into water environment, as well as the reservoir of AMR, which can be potentially discharged into treatment effluent. In this study, the antimicrobial resistome in WWTP was investigated using systematic sampling and shotgun metagenomic analysis over a variety of geographical locations, seasons, and biological treatment configurations. The results revealed that the transition of antimicrobial resistome occurred at two locations during the course of wastewater treatment process to develop the distinctive antimicrobial resistome in influent wastewater, activated sludge, and treatment effluent regardless of the geographical locations of WWTPs. The antimicrobial resistome in influent wastewater was characterized by higher abundance of antibiotic resistance genes (ARGs) resistant to clinically important drug classes, whereas sludge retained a higher abundance of multidrug ARGs associated with efflux pump. Seasonality was the primary factor to characterize the antimicrobial resistome in influent wastewater, which was partially succeeded to the subsequent resistome of activated sludge and treatment effluent. Importantly, antimicrobial resistome in the treatment effluent was dependent on process configuration of sludge separation. With conventional final sedimentation, antimicrobial resistome in the treatment effluent was partially affected by the resistome in influent wastewater, suggesting some ARGs in influent wastewater bypassed biological treatment and final sedimentation to be retained in the treatment effluent. On the contrary, the resistome of MBR effluent was independent from wastewater resistome, suggesting good reduction of ARG to clinically important drugs originated from influent wastewater.