bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sub-regional Trend of HIV Infection Among Antenatal Clinic Attendees in Andhra Pradesh (2003-2019)
Authors: Elangovan Arumugam , Santhakumar Aridoss , Mathiyazhakan Malathi , Nagaraj Jaganathasamy , David Joseph K. , Ganesh Balasubramanian , Manikandan Natesan , Mahalakshmi Padmapriya Vallalnathan , Kumar Pradeep 
Published: August 2022

Introduction:Analysis of local risks at sub-national levels and tailored interventions are being emphasized for effective HIV management. Andhra Pradesh (AP) is a high HIV prevalence state in India, with the second-highest number of people with HIV (PWH) and a consistent decline in HIV prevalence at the state level. Probing further into the region and district-wise levels and trends of HIV prevalence will provide critical insights into sub-regional epidemic patterns. Hence, this paper analyzes the regional and district-level trends of HIV prevalence among pregnant women attending the antenatal clinics (ANC) from 2003 to 2019 in AP, South India.Methods:HIV prevalence data collected from pregnant women in AP during HIV sentinel surveillance (HSS) between 2003 and 2019 was used for trend analysis. The consistent sites were grouped into three regions (Coastal Andhra, Rayalaseema and Uttar Andhra), totaling 39 sites, including 21 rural and 18 urban sites. Regional and district-level HIV prevalence was analyzed using the Chi-square trend test, and spatial analysis was done using QGIS software. For the last three HSS rounds, HIV prevalence based on sociodemographic variables was calculated to understand the factors contributing to HIV positivity in each region.Results:In total, 143,211 pregnant women were recruited. HIV prevalence in AP was 0.30% (95% CI: 0.22 - 0.39) in 2019. The prevalence was 0.31%, 0.35% and 0.22% in Coastal Andhra, Rayalaseema and Uttar Andhra, respectively. HIV prevalence had significantly (P < 0.05) declined in all regions. The overall trend indicated that the HIV prevalence was higher among older pregnant women and in urban regions. However, recent trends consistently report HIV positivity among young and new pregnant mothers, illiterates, and rural regions.Conclusion:The overall trend indicated that the HIV prevalence was higher among older pregnant women and in urban regions. However, recent trends consistently report HIV positivity among young and new pregnant mothers, illiterates, and rural regions. Identifying the contextual risk patterns associated with HIV transmission will further improve HIV preventive and management programs among the general population.
Effectors of Hyperlipidemia Among Patients with HIV/AIDS Taking
Second-line Antiretroviral Therapy Based on Registry Data
Authors: Xu Qianlei , Jin Yantao , Yang Chunling , Wang Dongli , Ma Yanmin , Liu Zhibin , Guo Huijun , Sang Feng 
Published: August 2022

Objective:
In this study, we aimed to determine the prevalence and effectors of hyperlipidemia
among people living with HIV/AIDS (PLWHA) and taking second-line antiretroviral
therapy (ART) using registry data in central China.

Methods:
We conducted a cross-sectional study and collected information of PLWHA on secondline
ART during 2018 from two medical registries. Hyperlipidemia was defined according to the
2016 Chinese guidelines for the management of dyslipidemia in adults. Univariate and multivariate
logistic regression analyses were performed to explore the influencing factors of hyperlipidemia.
We calculated odds ratios (ORs) and 95% confidence intervals (CIs).

Results:
A total of 2886 PLWHA taking second-line ART were included in this study, and 978
(33.9%) had hyperlipidemia. Female patients, those with hyperglycemia, and patients with CD4+
cell counts >500 cells/μL had a higher prevalence of hyperlipidemia with 37.0%, 49.0%, and
41.3%, respectively. Multivariate analysis showed that CD4+ cell count 350-500 cells/μL (OR =
1.72, 95% CI: 1.26-2.38), CD4+ cell count >500 cells/μL (OR = 2.49, 95% CI: 1.85-3.38), and FPG
>6.2 mmol/L (OR = 2.08, 95% CI:1.64-2.65) were risk factors for hyperlipidemia. Male sex (OR =
0.72, 95% CI: 0.61-0.85) and Hb <110 g/L (OR = 0.59, 95% CI: 0.45-0.76) were protective factors
against hyperlipidemia.

Conclusions:
PLWHA on second-line ART had a higher prevalence of hyperlipidemia. Gender,
CD4+ cell count, FPG, and hemoglobin were influencing factors of hyperlipidemia.
Molecular Docking and Simulation Binding Analysis of Boeravinone B with Caspase-3 and EGFR of Hepatocellular Carcinoma
Authors: Krishnamoorthy Praveen Kumar Posa , Balaraman Ashwini Devi , Priyadharshini Annadurai , Shanmugam Dharani Abirama Sundari , Muthukumaran Sivanandham , Kesavamurthy Amrutha , Revanasiddappa Prasanna Diddige 
Published: August 2022

Objective:Hepatocellular carcinoma (HCC) is a widely occurring cancer ranking second in humans, with an incidence rate of approximately 1.6% per year in India. Experimental analysis of the Boeravinones or the Rotenoids classification of compounds present in the roots of the Boerhaavia diffusa Linn plant has shown a wide range of anti-cancer activity against liver hepatoblastoma.Methods:Boeravinone B (BB) was screened from widely available Boeravinone A-E compounds based on a maximum drug-likeness score using Lipinski’s rule Five. BB was checked for anti-HCC activity by binding with the five receptors of VEGF, EGF, BCl2, Caspase-3 and Caspase-9 when compared with Sorafenib through molecular docking. GROMACS was used for simulating molecular dynamics.Results:BB has shown a negative maximum internal energy score of -8.04, -8.42, -6.66, -8.33 and -7.74 Kcal/mol when compared to Sorafenib’s internal energy score of -6.55, -7.12, -4.05, -5.48 and -6.12 Kcal/mol for VEGFR, EGFR, BCl2, Caspase-3 and Caspase-9 respectively. Simulation using GROMACS has revealed that RMSD results BB forms a more stable complex with the Caspase-3 and EGFR after 19s and 15s of simulation time. RMSF analysis has characterized local changes on 170-190 residues and 860- 900 residues in C-alpha atoms of BB-Caspase-3 and BB-EGFR complexes revealed protein flexibility.Conclusion:MMPBSA score of BB docked Caspase-3 and EGFR complexes were found to be -62.178 and -42.84 KJ/mol
Cognitive Performance and Diabetic Retinopathy: What Your Eyes Can
Reveal About Your Brain
Authors: de Almeida Faria Ana Cristina Ravazzani , Dall'Agnol Joceline Franco , Gouveia Aline Maciel , De Paiva Clara Inácio , Segalla Victoria Chechetto , Ogata Fernando Eiji , Baena Cristina Pellegrino 
Published: August 2022

Background:
Diabetic retinopathy (DR) is a chronic diabetes complication. People with Type 2 Diabetes Mellitus (T2DM) have two times the risk for dementia, suggesting it is a new chronic diabetes complication

Objective:
Evaluate the association of DR with cognitive performance in a T2DM population.

Methods:
Cross-sectional study with 251 T2DM adults from whom socio-demographic, clinical, laboratory data, a screening test for depression symptoms [Patient Health Questionaire-9 (PHQ-9)], Mini-Mental State Examination (MMSE), Semantic Verbal Fluency Test, Trail Making Test A and B, Word Memory test were collected and performed. All cognitive test scores were converted into Global Cognition z-Score [GCS(z)]. The association between GCS(z) < 0 with DR was performed using a multivariate binary logistic regression model adjusted for age ≥ 65 years, school years ≤ 6 years, DM duration ≥ 10 years, depression symptoms score > 9 at PHQ-9, arterial hypertension, physical activity, diabetic retinopathy, macular edema, and cardiovascular disease.

Results:
After exclusions, the 251 eligible patients were 56.6% female, with a mean age of 61.1(±9.8) years, DM duration of 12.6(±8.9) years, and 7.6(±4.2) years of school education. DR prevalence was 46.5%. Multivariate Logistic Regression Model showed an association between DR and GCS(z) < 0, with odds ratio (CI95%) of 2.50 (1.18-5.34), adjusted for age, low education level, arterial hypertension and depression symptoms [OD and CI95% respectively: 5.46(2.42-12.34); 12.19(5.62-26.46); 2.55(0.88-7.39); 3.53(1.55-8.07)].

Conclusion:
In this T2DM population, having DR increased the chance for worse cognitive performance even when adjusted for age, low education level, presence of arterial hypertension, and depression symptoms.
Investigation of the Tissue Degenerative Impact of Increased BMI in
Achilles Tendon via Strain Elastography and Finite Element Analysis
Authors: Siddiqui Rimsha , Mriza Eraj H. , Javed Ravish , Al-Qahtani Mahdi 
Published: August 2022

Background:
This study is focused to establish a relationship between poor muscle activity face by obese individuals due to the change in stiffness of the intramuscular mass of the lower limb. This issue is also common among athletes and physically active teenagers.

Objective:
The study is aimed at a subject assessment diagnosis technique named as Strain Elastography (SE)to measure muscle strain. Further, Finite Element Modelling (FEM) technique is used to investigate the strain and/or deformations generated in the Achilles Tendon (AT) models which were categorized according to their Body Mass Index (BMI) through computationally applied loadings.

Methods:
Total 54 volunteers with an average age of 21.85 ± 1.28 years were categorized into three groups according to their BMI (kg/m2); under BMI < 18.5 (n=14), normal BMI = 18.5-24.9 (n=20) and over BMI/obese > 25.0 (n=20). Additionally, multiple correlational analyses were performed between full range of BMI values and SE outcome.

Results:
Presence of significant difference (p<0.05) was measured between different categories for BMI, BFMI, FFMI, DLFC, tendon length, tendon thickness and SR. Moreover, multiple correlational analyses and scatter plot strengthen the results. For FEM simulations, the maximum deformation was observed at the proximal end of the tendon in all three groups.

Conclusion:
It can be concluded that change in tendon stiffness and resulting change in tendon structure was visualized with increased BMI. Moreover, obese individuals are more prone to tendon injury due to the increment in tendon thickness which causes bulging of the AT due to higher loads.
A Medieval Surgery, Illustrated: The First Recorded Surgical Separation of Conjoined Twins
Authors: Zamora Krista , Birnfeld Caroline Da Rocha , Barrios Andrew 
Published: August 2022

Vol 3. No. 3 (2022)
This issue of SourceLab introduces readers to an example of a Byzantine surgery undertaken in the tenth century, preserved in the Madrid Skylitzes, a twelfth-century illustrated manuscript.
This publication is part of the digital documentary edition series SourceLab, based at the University of Illinois at Urbana-Champaign. Our Editorial Board conducts rigorous peer-review of every edition.
The Impact of Nonrandom Missingness in Surveillance Data for Population-Level Summaries: Simulation Study
Authors: Weiss Paul Samuel , Waller Lance Allyn 
Published: August 2022

Background
Surveillance data are essential public health resources for guiding policy and allocation of human and capital resources. These data often consist of large collections of information based on nonrandom sample designs. Population estimates based on such data may be impacted by the underlying sample distribution compared to the true population of interest. In this study, we simulate a population of interest and allow response rates to vary in nonrandom ways to illustrate and measure the effect this has on population-based estimates of an important public health policy outcome.

Objective
The aim of this study was to illustrate the effect of nonrandom missingness on population-based survey sample estimation.

Methods
We simulated a population of respondents answering a survey question about their satisfaction with their community’s policy regarding vaccination mandates for government personnel. We allowed response rates to differ between the generally satisfied and dissatisfied and considered the effect of common efforts to control for potential bias such as sampling weights, sample size inflation, and hypothesis tests for determining missingness at random. We compared these conditions via mean squared errors and sampling variability to characterize the bias in estimation arising under these different approaches.

Results
Sample estimates present clear and quantifiable bias, even in the most favorable response profile. On a 5-point Likert scale, nonrandom missingness resulted in errors averaging to almost a full point away from the truth. Efforts to mitigate bias through sample size inflation and sampling weights have negligible effects on the overall results. Additionally, hypothesis testing for departures from random missingness rarely detect the nonrandom missingness across the widest range of response profiles considered.

Conclusions
Our results suggest that assuming surveillance data are missing at random during analysis could provide estimates that are widely different from what we might see in the whole population. Policy decisions based on such potentially biased estimates could be devastating in terms of community disengagement and health disparities. Alternative approaches to analysis that move away from broad generalization of a mismeasured population at risk are necessary to identify the marginalized groups, where overall response may be very different from those observed in measured respondents.
Optimalisasi Latihan Relaksasi Otot Progresif Berpengaruh terhadap Penurunan Tingkat Kecemasan pada Lansia pada Masa Pembatasan Sosial Bersekala Besar di Posyandu Lansia
Authors: Hikmah Nur , Yuliadarwati Nungki Marlian , Utami Kurnia Putri , Multazam Ali , Irawan Dimas Sondang 
Published: August 2022

Kesehatan pada lanjut usia didasari oleh aspek fisik, sosial, ekonomi dan psikologis yang menyebabkan mudah tersinggung, kemunduran fisik terutama kondisi Kesehatan selama Pembatasan social berskala besar (PSBB) akibat wabah Covid-19 akan berimbas pada Kesehatan seperti musculoskeletal, kardiovaskular, perasaan tidak berguna yang mentebabkan terjadinya kecemasan yang dapat diselesaiakan dengan metode terapi Latihan dengan relaksasi otot progresif. Tujuan penelitian ini untuk mengetahui pengaruh metode relaksasi otot progresif terhadap tingkat kecemasan pada lanjut usia. Penelitian ini merupakan penelitian pre-eksperimen dengan model pendekatan pre-test post-test one group design dengan alat pengukuran tingkat stres Hamilton Anxiety Rating Scale (HARS). Hasil analisis uji Paired t-test diperoleh hasil signifikansi 0,000 (p< 0,05) maka dari hasil tersebut dapat disimpulkan bahwa Ha diterima sehingga terdapat pengaruh latihan relaksasi progresif terhadap penurunan tingkat kecemasan pada lanjut usia
Pengaruh Adaptive Exercise terhadap Temperatur Tubuh Anak dengan Gangguan Neurologis Sistem Saraf Pusat
Authors: Mulyadi Soffil Yudha , Arti Widi , Widanti Herista Novia , Anjasmara Bagas 
Published: August 2022

Kasus ganggguan neurologis system saraf pusat anak semakin meningkat tiap tahun, khususnya cerebral palsy dan traumatic brain injury. Kondisi umum tubuh anak dengan gangguan neurologis sistem saraf pusat yang mayoritas mengalami imobilisasi tentu akan menurun. Suhu menjadi Salah satu kondisi tubuh yang menurun pada anak bahkan anak tersebut sampai masuk dalam kategori hipotermia. Exercise sederhana dan mudah yang secara rutin dilakukan di rumah merupakan salah satu perlakuan sederhana agar temperatur tubuh anak selalu terjaga. Penelitian ini bertujuan untuk melihat efek adaptive exercise terhadap temperatur tubuh anak yang memiliki gangguan neurologis sistem saraf pusat. Penelitian ini merupakan penelitian eksperimental one grup pre dan post test. Subyek perempuan 11 orang dan laki laki 20 orang dengan rentang umur 2 – 10 tahun. Adaptive exerceise terdiri dari warming up waktu 5 menit, core movement waktu 25 menit, dan cooling down waktu 5 menit. Data diuji dengan paired T test. suhu tubuh pre test ( 36,12 ± 0,53) oC, suhu tubuh post test (36,63 ± 0,6) oC dan p = 0,00. Adaptive exercise dapat menaikan temperatur tubuh tetapi peningkatan temperatur tersebut masih didalam rentang yang normal.
Liberalismo político (Estado) y Liberalismo económico (Moneda). Sus raíces en común, y una propuesta de definición conceptual
Authors: Medina Carlos 
Published: August 2022

El liberalismo está fundado en una metafísica nominalista que rechaza la capacidad de la razón humana de alcanzar un conocimiento esencial del mundo. Visto así, cualquier orden óptimo que imaginemos cualitativamente en los planos antropológico, político y económico sería sólo, en efecto, un mero producto de la imaginación desprovisto de valor noético efectivo. En el caso del liberalismo político esto se traduce en la afirmación de un concepto meramente formal de la autonomía. En el caso del liberalismo económico es el deísmo, en cuanto evolución ilustrada de la premisa nominalista, el que moldea el pensamiento: el Mercado es concebido desde esta perspectiva como una esfera autónoma y autorregulada providencialmente de la cual solo podemos conocer las leyes procedimentales que rigen su mecanismo interno.
Palabras claves: liberalismo, nominalismo, Mercado, deísmo, autonomía.
Entre a cura e o curativo cotidiano
Authors: Timóteo Larissa Vinhas , Silveira Carlos Roberto da 
Published: August 2022

Michel Foucault buscou em seus pensamentos problematizar o sujeito na relação com o saber, o poder e consigo. Este estudo problematiza sobre a questão do sujeito/consigo. O objetivo pretendido foi compreender sobre o cuidado de si dos docentes da graduação em Enfermagem de uma Faculdade de Enfermagem do interior do estado de Minas Gerais, isso ao levar em consideração que se trata de uma profissão, cujo o objeto de trabalho é o cuidado que está ligado ao cuidado ao outro. A metodologia se baseia em uma análise reflexiva da teoria foucaultiana, com enfoque nos discursos dos docentes de Enfermagem. Os resultados evidenciaram que os docentes não compreendem a diferenciação do cuidado de si para o autocuidado. Na discussão fica evidente, através dos discursos analisados, em que os sujeitos da pesquisa, afirmam que praticam o cuidado de si, mas o que eles fazem na verdade, na maioria das vezes, é o autocuidado. Quanto às considerações finais, os docentes de Enfermagem demonstraram não exercer o cuidado de si e afirmaram que o cuidado de si interfere no cuidado com o outro, inclusive em suas práticas docentes. Acreditam que a pesquisa possibilita a reflexão para a (des)construções de suas práticas de cuidado. Essa pesquisa se desenvolveu com auxílio do Grupo de Estudos Foucaultianos em Educação da Universidade São Francisco e trata-se de uma parte desenvolvida no mestrado em Educação.
The Implementation of Storytelling in Learning Bahasa Indonesia to develop Students' Emotional Intelligence
Authors: Mustika Yumna Gina , Kustiarini Kustiarini 
Published: August 2022

This descriptive study investigates the implementation of storytelling in learning Bahasa Indonesia to develop second graders’ emotional intelligence. This study was conducted at SDIT Insan Mulia Surakarta from February to September 2021. This study involved the principal, teacher and several students of class 2C, and other teachers teaching the second grade. Data collection techniques were interviews, observation, and documentation. The storytelling was carried out through planning, implementation, and evaluation. Storytelling was carried out using images. From this study, self-confidence, responsibility, and tolerance are examples of emotional intelligence that emerge through the storytelling for learning Bahasa Indonesia.
Application of the MADM Method for the Admission System for Islamic Religious Trustees
Authors: Rinaldy Sawitha Yuliana , Arifin Aridhanyati 
Published: August 2022

The selection process for Islamic tutor and the decision to pass or fail is made by subjective views of the selector. The konvensional process takes a lot of time. It is necessary to have Decision Support System (DSS) to minimize the subjective side of the selectors and streamline the selection process so that effective decision can be obtained. The character of this problem matches the characteristic of Multi Attribute Decision Making (MADM) model. A combination of Simple Addictive Weighting (SAW) and Technique for Others Reference by Similarity to Ideal Solution (TOPSIS) are selected to solve MADM model. SAW used to rank decision while TOPSIS used to calculate level 2 criteria. Based on testing of 30 data samples using Single Detection Threshold method, the system performance accuracy rate is 83,33% and precision rate is 77%. The combination of the two method has been successfully applied and provide accurate and precise recommendations.
Home Purchase Recommendation System Using Fuzzy Tsukamoto Method
Authors: Pangestu Dwiki Rian , Widaningrum Ida , Astuti Arin Yuli 
Published: August 2022

Abstrak—Tingkat kebutuhan warga di bidang properti terus bertambah bersamaan dengan perkembangan jumlah penduduk. Hal tersebut karena bertambahnya jumlah populasi, dan tempat tinggal merupakan salah satu kebutuhan pokok yang harus dipenuhi. Sebuah rumah, biasanya merupakan implementasi dari keinginan seseorang tentang tempat tinggal yang nyaman menurut kriterianya. Oleh karena itu ketika ingin membeli atau mendirikan rumah, akan memilih sesuai dengan keinginannya. Terdapat banyak sekali rumah, tipe dan gaya ditawarkan oleh agen properti, mengakibatkan sedikit kesulitan ketika memilih mana yang sesuai dengan idamannya. Oleh sebab itu, ditawarkan sebuah sistem yang akan mendukung keputusan bagi konsumen dalam menentukan rumah mana yang tepat untuk menjadi tempat tinggalnya. Kriteria yang digunakan terdiri dari harga, luas tanah, luas bangunan, mutu bangunan, posisi, kelengkapan, serta sarana umum. Sistem pendukung keputusan ini, mengimplementasikan metode Fuzzy Tsukamoto untuk mendapatkan hasil akhirnya. Sistem berbasis website, bahasa pemrograman PHP dengan aplikasi kode visual studio serta xampp dan pengujian black box. Hasil yang didapatkan berupa rekomendasi pemilihan rumah berdasarkan penentuan bobot oleh konsumen itu sendiri. Kata Kunci— Sistem Pendukung Keputusan, Rumah, Fuzzy Tsukamoto, Website, PHP Abstract—In the real estate sector, the level of demand of residents continues to increase with the development of the population. This is because the population is growing, and housing is one of the basic needs that must be met. The embodiment of someone's desire for a home, a comfortable place to live, usually by standards. So when you buy or build a house, you have a choice. With so many homes, types, and styles offered by real estate agents, it can be a bit difficult to choose the home that fits your dreams. Thus, a system is provided to help consumers decide which housing is suitable for them to live in. Standards include price, land area, building area, building quality, location, completeness, and public facilities. This decision support system implements the Fuzzy Tsukamoto method to achieve the final result. A website-based system, PHP programming language with Visual Studio Code application, xampp, and black-box testing. The result obtained is a recommended format for home selection based on the consumer's weight determination.