bluuebunny/crossref_metadata_2025_split huggingface dataset:
Living in an online world: Social media experiences of adolescents and young adults with cancer
Authors: Reuman Hannah , Kerr Katherine , Sidani Jaime , Felker James , Escobar‐Viera César , Shensa Ariel , Maurer Scott H. 
Published: March 2022

AbstractBackgroundDespite widespread use, little is known about how adolescents and young adults (AYA) with cancer use social media (SM). This research characterized use and self‐reported SM experiences among AYA with cancer.ProcedureAYA, aged 12‐26 years, receiving cancer care completed a mixed‐methods survey regarding SM experiences. Clinical information was obtained from the electronic medical record. Data were analyzed with descriptive statistics, t tests, and qualitative content analysis.ResultsThirty‐nine AYA with average age 16 (SD = 3.2) years participated. Most were Caucasian (92%) males (54%). Participants had leukemia/lymphoma (56%), solid tumors (33%), and brain tumors (10%). Nearly all (97%) used SM, with YouTube, Snapchat, and Instagram being the most popular. AYA self‐reported lower SM use than their smartphone data indicated (2.8 hours/day, SD = 1.2 vs 3.4 hours/day, SD = 1.3; P < 0.001). Participants used SM to obtain information about their cancer (45%), post about cancer (47%), and read about others’ cancer experience (50%). One‐third made a friend with cancer through SM (32%). Qualitative results indicated that AYA had positive cancer‐related SM experiences, including feelings of support (54%), community (27%), distraction (8%), and inspiration (8%). Most denied negative experiences (78%); however, 17% reported cyberbullying related to cancer.ConclusionsAYA with cancer avidly use SM, noting it provides a sense of support and community. However, one‐sixth reported cancer‐related cyberbullying. AYA oncology providers have an opportunity to enhance positive and blunt negative SM interactions by addressing and guiding SM use in AYA patients.
Rhabdomyosarcoma in low‐ and middle‐income countries: A report from the Asociacion de Hemato‐oncología Pediatrica de Centro América (AHOPCA)
Authors: Garrido Claudia , Letona Tomás , Godoy Susana , Antillón Federico , Valverde Patricia , Luna‐Finemann Sandra , Rodríguez‐Galindo Carlos , Fuentes Soad , Arambu Ingrid , Calderón Patricia , Ortiz Roberta , Montero Margarita , Blanco Jessica , Valsecchi Maria Grazia , Ferrari Andrea 
Published: March 2022

AbstractThis report describes the results of an observational study dedicated to rhabdomyosarcoma developed by the Asociación de Hemato‐oncología Pediatrica de Centro América (AHOPCA) between 2001 and 2018. Overall, 337 previously untreated patients < 18 years old were included in the analysis; 58% had unresected disease, and 19% were metastatic at diagnosis. With a median follow‐up of 6.6 years, five‐year event‐free and overall survival rates were 30% and 33%, respectively. Local progression/relapse was the main cause of treatment failure.
Suitability examination of a new cellulosic fiber extracted from the stem of Ventilago maderaspatana plant as polymer composite reinforcement
Authors: Rathinavelu Ravichandaran , Arumugam Eakambaram , Paramathma Baskara Sethupathi 
Published: March 2022

AbstractThis article is designed to examine the aptness of Ventilago maderaspatana fiber (VMF) as reinforcement in polymer composites. A significant quantity of cellulose fraction (56.12 ± 5.42 wt%) in the VMF was estimated via chemical analysis. The X‐ray diffraction analysis identified the presence of cellulose type‐I and peak cellulose type‐IV in the VMF, and it quantified the crystallinity index (25.88%) and crystalline size (26.12 nm) of the VMF. Various chemical functional groups in the VMF were categorized with the help of Fourier‐transform infrared spectroscopic analysis. The thermal degradation behavior of the VMF was investigated with the help of thermogravimetric analysis, and it determined the thermal stability (200°C) and kinetic activation energy (62.46 kJ/mol) of VMF. The scanning electron microscopic and energy dispersive X‐ray spectroscopic analysis revealed the existence of contaminations, hemicellulose and lignin on the outer layer of VMF, and it was confirmed by atomic force microscopic analysis. The lower density (1236 ± 18.42 kg/m3) and better tensile strength (383.7 ± 16.07 MPa) of the VMF enabled the possibility of use as reinforcement in fiber reinforced plastics.
Effect of starch nanocrystals addition on the physicochemical, thermal, and optical properties of low‐density polyethylene (LDPE) films
Authors: Martins Paola Chaves , Latorres Juliana Machado , Martins Vilásia Guimarães , Machado Ana Vera 
Published: March 2022

AbstractThe aim of this study is to add rice and potato starch nanocrystals (SNCs) to a low‐density polyethylene (LDPE) matrix to reinforce its structure, improve its characteristics, and broaden its applicability. The SNCs were produced by acid hydrolysis and applied to the LDPE matrix by extrusion at a concentration of 0.5% and 1%. The films were characterized in terms of physical–chemical, thermal, and structural properties. The addition of 1% SNCs produced from rice starch reduced the oxygen permeability to 1.57 × 10−4 (ml mm/MPa/min/cm2) and increased the thermal stability of the films. The addition of potato starch SNCs in a 1% proportion increased the crystallinity of the films to 81.6%. Therefore, the incorporation of starch SNCs in the LDPE matrix showed adequate compatibility and the ability to improve the properties of the films. The mixture of LDPE with biodegradable polymers can be an alternative that can contribute to the increase in the rate of biodegradability.
Alignment of K‐8 mathematics interventions with strands of mathematical proficiency in meta‐analytic research
Authors: Pulles Sandra M. , Burns Matthew K. 
Published: March 2022

AbstractThe purpose of this paper was to examine current mathematics interventions designed for students in kindergarten through eighth grade to determine how often they incorporated the five strands of mathematical proficiency identified by the National Research Council (2001). The five strands are conceptual understanding, procedural knowledge, strategic competence, adaptive reasoning, and productive disposition. A systematic review of the literature resulted in 13 meta‐analyses of that studied a total of 19 unique interventions. The five strands of mathematical proficiency were then compared to each intervention to determine with which strand(s) the intervention aligned. None of the 19 interventions contained all five strands, but interventions could be combined to enhance math proficiency. The strands of mathematics proficiency could provide a framework with which to meaningfully combine intervention components.
The association of anemia with the clinical outcomes of community‐acquired pneumonia in children
Authors: Chang I‐Fan , Shih Wei‐Liang , Liu Yun‐Chung , Ho Te‐Wei , Yen Ting‐Yu , Chang Hsiu‐Hao , Chang Luan‐Yin , Fang Chi‐Tai , Lai Feipei 
Published: March 2022

AbstractObjectivesAnemia is associated with severe outcomes in adult community‐acquired pneumonia (CAP), but few studies investigated its association with pediatric CAP. Hence, we tried to delineate the association of anemia with the clinical outcomes of CAP in children.MethodsThis retrospective cohort study was conducted from 2010 to 2019 in a medical center. Inpatients aged 6 months to 17 years who were diagnosed with CAP and without major underlying diseases were included. The subjects' clinical data within 24 h of admission and clinical outcomes were collected. We accessed the rates of adverse outcomes and the adjusted odds ratios (ORs) of these outcomes between anemic and nonanemic patients, as well as among patients with different types of anemia.ResultsIn this study of 3601 patients, the prevalence of anemia was 11.6% (418/3601). Anemic patients had higher rates of intensive care (16.8% vs. 3.6%; p < 0.001), endotracheal intubation (11.0% vs. 1.3%; p < 0.001), and empyema (8.6% vs. 0.6%; p < 0.001) than nonanemic patients. In addition, anemia was independently associated with intensive care (adjusted OR, 3.00; 95% confidence interval [CI], 2.03–4.42), endotracheal intubation (adjusted OR, 3.79; 95% CI, 2.17–6.63), and empyema (adjusted OR, 4.72; 95% CI, 2.30–9.69). Iron‐deficiency anemia (IDA) and normocytic anemia were associated with these adverse outcomes but not with anemia due to thalassemia trait.ConclusionAnemia is a biomarker associated with poor outcomes in pediatric CAP, and patients with IDA or normocytic anemia should be carefully monitored and managed since they may have higher disease severity.
High‐flow nasal cannula oxygen in children with bronchiolitis: A randomized controlled trial
Authors: Eşki Aykut , Öztürk Gökçen Kartal , Turan Caner , Özgül Semiha , Gülen Figen , Demir Esen 
Published: March 2022

AbstractObjectiveTo determine whether high‐flow nasal cannula oxygen (HFNCO) provided enhanced respiratory support in bronchiolitis than low‐flow oxygen (LFO).MethodsWe conducted a prospective, randomized controlled trial in children between 1 and 24 months diagnosed with moderate‐to‐severe bronchiolitis requiring oxygen therapy. Participants received LFO via face mask (6–10 L/min) or HFNCO (2 L/kg/min). Primary outcomes were the time that heart rate (HR) and respiratory rate (RR) return to their normal range for age and the time that baseline clinical respiratory score (CRS) regress to a lower severity score. Secondary outcomes were changes in HR, RR, and CRS over time, length of stay (LOS), duration of oxygen requirement, treatment failure, and adverse event (AE).ResultsEighty‐seven children were enrolled (48 in LFO; 39 in HFNCO). The time that HR and RR baseline values reached their normal range for age was shorter in HFNCO therapy (2.0 h [1.0–4.0] vs. 12.0 h [2.0–24.0], and 4.0 h [2.0–12.0] vs. 24.0 h [4.0–48.0], respectively; p < 0.001); additionally, the improvement in CRS emerged more quickly in children treated with HFNCO (2.0 h [1.0–4.0] vs. 4.0 h [2.0–24.0]; p = 0.003). While the duration of oxygen requirement (19.0 h [4.0–30.0] vs. 29.5 h [14.0–45.7]; p = 0.009) and treatment failure (3% vs. 21%) was statistically lower in children who received HFNCO, there were no differences in LOS and AE between groups.ConclusionHFNCO may provide enhanced respiratory support with a notable improvement in HR, RR, and CRS than LFO. Comprehensive studies are needed to assess the clinical efficacy of HFNCO therapy.
Serum thymidine kinase 1 concentration as a predictive biomarker in prostate cancer
Authors: Lundgren Per‐Olof , Tribukait Bernhard , Kjellman Anders , Norming Ulf , Jagarlmudi Kiran , Gustafsson Ove 
Published: March 2022

AbstractBackgroundThymidine kinase 1 (TK1) recycles DNA before cell division. We do not know if baseline blood concentrations of TK1 predict death in prostate cancer within 30 years.Our objective is to determine if there is an association between baseline levels of TK1 and future prostate cancer‐specific mortality.MethodsWith a “proof of concept” approach, we performed a nested case–control study among 1782 individuals screened for prostate cancer between 1988 and 1989. The concentration of TK1 was measured in frozen serum from 330 men, 36 of whom have died of prostate cancer.The primary endpoint was prostate cancer‐specific mortality and outcomes after 30 years were analyzed using logistic regression modeling odds ratios (Ors).ResultsThe estimated OR (adjusted for age) for dying from prostate cancer among the men who had a TK1 value in the upper tertile was 2.39 (95% confidence interval 1.02–5.63). The corresponding OR, regardless of the cause of death, was 2.81 (1.24–6.34).ConclusionsHigh levels of TK1 predicts death in prostate cancer within 30 years of follow‐up.
ELA as English Language Abolition: Toward a Pedagogy of Communicative Belonging
Authors: Souto‐Manning Mariana , Martinez Danny C. , Musser Adam D. 
Published: March 2022

AbstractRacialized notions of language and literacy are harmful to children in U.S. schools, and English Language Arts is a primary site whereby white supremacist language ideologies are enacted and justified, being most harmful to Black, Indigenous, and other students of Color. The authors—Mariana Souto‐Manning, Danny C. Martinez, and Adam D. Musser—former ELA teachers and current university‐based educators committed to the pursuit of justice, are motivated by the questionsWhat can we do?andWhat should we do?in response to this harm. This conceptual article briefly traces the history of harm embedded in ELA classrooms before theorizing a debordering of English Language Arts and advancing ahealing pedagogy for communicative belonging. Guided by the restorative justice principles of harms, needs, and obligations, it engages quilting as metaphor and process. Through quilting, the authors inquire into the harms of ELA as a disciplinary project rooted in exclusion, anti‐Blackness, and colonialism. Undertaking reparative caring and attending to Black, Indigenous, and other students of Color often unaccounted for in education reforms, Souto‐Manning, Martinez, and Musser advance ELA as English Language Abolition, seeking to abolish tokens of diversity in ELA classrooms and create spaces for true belonging via collaborative, future‐oriented work. Ultimately, while recognizing that the future imaginings of communicative belonging are part of a utopian project that imagines learning ecologies freed from and free of colonial and white logics, this article forwards a healing pedagogy of communicative belonging, offering the potential to abolish the harms long perpetrated in ELA classrooms by dominant conceptualizations of ELA.
Transition Metal‐ and Oxidant‐Free Regioselective Synthesis of 3,4,5‐Trisubstituted Pyrazoles by Means of [3+2] Cycloaddition Reactions
Authors: Allaka Bhargava Sai , Basavoju Srinivas , Gamidi Rama Krishna 
Published: March 2022

AbstractA highly efficient regioselective synthesis of 3,4,5‐trisubstituted pyrazoles via transition metal‐ and oxidant‐free, three component [3+2] cycloaddition with thiazolidinedione chalcones, benzaldehydes and N‐tosylhydrazine is described. The reaction proceeds through C−C and C−N bond formations under mild reaction conditions to produce structurally diverse polysubstituted pyrazoles in moderate to good yields.
Design of a secure and privacy preserving authentication protocol for telecare medical information systems
Authors: Sumithra V. , Shashidhara R. , Mukhopadhyay Debajyoti 
Published: March 2022

AbstractWith the advancement of communication technology, Telecare Medicine Information Systems (TMIS) provides convenient healthcare services for patients, doctors, and health organizations over the insecure Internet. As a result, when accessing sensitive medical data over an insecure connection, user privacy, data security, and user authentication is very crucial. A secure authentication protocol plays a crucial role in securing communications over TMIS, these environments are very vulnerable to numerous attacks due to resource constraints and the nature of the communication medium. Recently, an efficient authentication framework has been introduced for TMIS to address various security issues. However, the existing mutual authentication and key agreement protocols are vulnerable to replay attacks, insider attacks, impersonation attacks, and password guessing attacks. Furthermore, the current authentication systems do not guarantee user privacy and the fair key agreement between the patient and the medical server. We propose a more robust authentication approach for healthcare information systems to address these security issues. To assess the authentication protocol's security strength, we employ formal verification tools like Automated Validation of Internet Security Protocols and Applications (AVISPA). Finally, a thorough performance analysis demonstrates that the proposed mutual authentication framework not only ensures privacy but also maintains a low computing overhead. As a result, when compared to other related systems, the proposed authentication protocol is both secure and computationally efficient.
An experimentation framework for validating architectural properties as proxies for the ilities
Authors: Salado Alejandro 
Published: March 2022

AbstractDesired system ilities, understood as lifecycle properties, generally drive the value of a system's architecture. However, ilities are hard to predict during system architecture development before the architecture has been instantiated with a system design. In this paper, an experimentation framework that can be employed to validate the adequacy of using architectural properties as proxies for ilities is presented. The experimentation framework builds upon a theoretical, generic conceptualization of ilities, which helps to formally justify the difficulties of and limitations in predicting how architectural choices influence system ilities. Application of the experimental framework is showcased with a notional scenario, where the framework is used to evaluate how different system topologies influence the integrability of a system.
Seismic reliability evaluation of a tall concrete‐timber hybrid structural system
Authors: Chen Jiawei , Xiong Haibei , Ventura Carlos E. 
Published: March 2022

SummarySeismic reliability analysis is important for performance evaluation and structure design of novel structural systems since it can consider inherent uncertainties in seismic actions and structural properties. In this paper, seismic reliability analyses were performed on an innovative high‐rise concrete‐timber (FaB) hybrid structural system. The FaB system combines a concrete frame‐tube structure with large story height as the main structure and multi‐story timber structures on each concrete slab as substructures. To better assess the seismic reliability of the FaB system, response surface methods with either the Lasso regression approach or the machine‐learning‐based symbolic regression approach were conducted and compared. Uncertainties, including ground motions, elastic properties and ductility factor of the concrete main structure, mechanical properties of timber substructures and connections (i.e., rubber bearings), mass ratios, and fitting errors, were considered in formulating the limit‐state performance functions. Tens of thousands of non‐linear time‐history analyses were run to establish the response database of the FaB system, and the reliability indexes of both the concrete main structure and timber substructures were calculated. The results show that the symbolic regression approach can formulate simpler response surface functions with similar results compared to the Lasso regression approach. The maximum difference of reliability indexes between the two approaches is less than 8.3%. For the concrete main structure, the seismic reliability indexes are in a range of 1.068 to 4.223 under different performance objectives and hazard levels, while those of timber substructures are in a range of 0.892 to 2.28. The corresponding non‐exceedance probabilities of failure are between 81% and 99%, which reveals the safety and robustness of the FaB system. Meanwhile, the adoption of rubber bearings in the FaB system can enhance the seismic reliability indexes of timber substructures by 9% to 28% but has little influence on those of the concrete main structure. Outcomes of this study can serve as efficient tools to quantify the seismic performance and evaluate the performance‐based seismic design methodology for the proposed tall concrete‐timber hybrid structural system.
Pathways explaining racial/ethnic disparities in incident all‐cause and Alzheimer's disease dementia among older US men and women
Authors: Beydoun May A. , Weiss Jordan , Beydoun Hind A. , Fanelli‐Kuczmarski Marie T. , Hossain Sharmin , El‐Hajj Ziad W. , Evans Michele K. , Zonderman Alan B. 
Published: March 2022

AbstractIntroductionRacial disparities in Alzheimer's disease (AD) and all‐cause dementia (DEMENTIA) incidence may exist differentially among men and women, with unknown mechanisms.MethodsA retrospective cohort study examining all‐cause and AD dementia incidence was conducted linking Third National Health and Nutrition Examination Survey (NHANES III) to Centers for Medicare & Medicaid Services Medicare data over ≤26 years of follow‐up (1988 to 2014). Cox regression and generalized structural equation models (GSEMs) were constructed among men and women ≥60 years of age at baseline (N = 4592). Outcomes included onset ages of all‐cause and AD dementia, whereas the main exposures were race/ethnicity contrasts (RACE_ETHN). Potential mediators) included socio‐economic status (SES), lifestyle factors (dietary quality [DIET] nutritional biomarkers [NUTR], physical activity [PA], social support [SS], alcohol [ALCOHOL], poor health [or HEALTH], poor cognitive performance [or COGN]. In addition to RACE_ETHN, the following were exogenous covariates in the GSEM and potential confounders in Cox models: age, sex, urban‐rural, household size, and marital status.ResultsNon‐Hispanic Black (NHB) women had a higher risk of DEMENTIA versus non‐Hispanic White (NHW) women in GSEM, consistent with Cox models (age‐adjusted model: hazard ratio [HR] = 1.34, 95% confidence interval [CI]: 1.10 to 1.61). The total effect of this RACE_ETHN contrast in women was explained by four main pathways: (1) RACE_ETHN→ poor cognitive performance (COGN, +) → DEMENTIA (+); (2) RACE_ETHN → SES (−) → COGN (−) → DEMENTIA (+); (3) RACE_ETHN → SES (−) → physical activity (PA, +) → COGN (−) → DEMENTIA (+); and (4) RACE_ETHN → SES (−) → DIET (+) → COGN (−) → DEMENTIA (+). A reduced AD risk in Mexican American (MA) women versus NHW women upon adjustment for SES and downstream factors (HR = 0.53, 95% CI: 0.35 to 0.80). For the non‐White versus NHW contrast in incident DEMENTIA, pathways involved lower SES, directly increasing cognitive deficits (or indirectly through lifestyle factors), which then directly increases DEMENTIA .DiscussionSocioeconomic and lifestyle factors explaining disparities between NHB and NHW in dementia onset among women are important to consider for future observational and intervention studies.
Blue light irradiation increases the relative abundance of the diatom Nitzschia palea in co‐culture with cyanobacterium Microcystis aeruginosa
Authors: Watanabe Shunsuke , Matsunami Naoki , Okuma Ikki , Naythen Podiapen Tannen , Fujibayashi Megumu , Iseri Yasushi , Hao Aimin , Kuba Takahiro 
Published: March 2022

AbstractLake eutrophication is associated with cyanobacterial blooms. The pennate diatom Nitzschia palea (N. palea) inhibits the growth of the cyanobacterium Microcystis aeruginosa (M. aeruginosa); therefore, increasing the relative abundance of N. palea may contribute to the inhibition of Microcystis blooms. Several studies have demonstrated that blue light irradiation promotes diatom growth and inhibits cyanobacterial growth. In this study, we evaluated the effects of blue light irradiation on N. palea and M. aeruginosa abundance. Monocultures and co‐cultures of N. palea and M. aeruginosa were exposed to blue light and fluorescent light at 32 μmol photons m−2 s−1. The relative abundance of N. palea under fluorescent light decreased gradually, whereas the abundance under blue light was relatively higher (approximately 74% and 98% under fluorescent light and blue light, respectively, at the end of the experiment). The inhibition efficiency of blue light on the growth rate of M. aeruginosa was related to the light intensity. The optimal light intensity was considered 20 μmol photons m−2 s−1 based on the inhibition efficiency of 100%. Blue light irradiation can be used to increase the abundance of N. palea to control Microcystis blooms.Practitioner Points

The effects of blue light irradiation on N. palea abundance was discussed.
Monocultures and co‐cultures of N. palea and M. aeruginosa were exposed to blue light and to fluorescent light.
The relative abundance of N. palea increased upon irradiation with blue light in co‐culture with M. aeruginosa.