bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidencia del manejo de miopatías asociadas a estatina con coenzima Q10
Authors: Ferreira Alfaya Francisco Javier 
Published: March 2022

Introducción: La incidencia de eventos cardiovasculares fatales es muy elevada y el tratamiento con estatinas es vital para reducir este riesgo en muchos pacientes, sin embargo, sus efectos adversos sobre el músculo esquelético dificultan la adherencia o la continuación del mismo. Se ha propuesto la suplementación de coenzima Q10 para revertir mialgias asociadas a el empleo de estatinas. Los ensayos clínicos que se realizaron en los últimos 10 años obtuvieron resultados contrapuestos.
El objetivo de este trabajo es revisar la evidencia sobre la eficacia del empleo de suplementos de coenzima Q10 en para mitigar las miopatías causadas por las estatinas.
Metodología: Se realizó una búsqueda sistemática de la literatura publicada hasta Julio de 2020. Las bases de datos consultadas fueron MEDLINE y SCOPUS. También se consultaron instituciones como la Agencia Española del Medicamento y Productos Sanitarios (AEMPS), la European Medicines Agency (EMA) y la Food and Drug Administration (FDA).
Resultados: La etiología de las mialgias asociadas a estatinas sigue siendo desconocida y la evidencia encontrada en los ensayos clínicos y metaanalisis obtuvieron conclusiones dispares. La European Medicine Agency (EMA) solo considera el empleo de suplementos en síndrome de deficiencia primaria de coenzima Q10, mientras en Reino Unido el National Institute for Health and Care Excellence (NICE) y el National Institute of Health (NIH) no recomiendan el empleo de estos suplementos para tratar mialgias asociadas al empleo de estatinas.
Conclusiones: El conjunto de los estudios analizados no consiguió una evidencia unánime para poder recomendar este empleo de suplementos de coenzima Q10 de modo confiable. Se necesitan estudios mejor diseñados que aporten reproducibilidad y robustez a futuros ensayos clínicos.
Plantas medicinales que actúan sobre el sistema inmune
Authors: Perejón-Rubio Inmaculada del Rocío , García-Gimenez María Dolores 
Published: March 2022

Introducción: El sistema inmune puede verse afectado por distintos factores, por lo que en ocasiones el empleo de plantas medicinales es un remedio efectivo para estimular las defensas y prevenir resfriados. Con la llegada actual de la pandemia de COVID-19 se ha incrementado notablemente la demanda de estos medicamentos a base de plantas medicinales, por lo que se hace necesario su conocimiento por parte de los farmacéuticos comunitarios entre otros profesionales de la salud.
Método: Se ha realizado una revisión bibliográfica sobre distintas plantas que actúan a nivel del sistema inmune en distintas bases de datos, revistas especializadas y libros.
Resultados: Echinacea purpurea (L.) Moench, Panax ginseng C.A. Meyer, Eleutherococcus senticosus Rupr. y Maxim. y Pelargonium sidoides DC. han demostrado su actividad inmunoestimulante, indicadas para la prevención de afecciones respiratorias leves. Por otro lado, se distinguen distintas plantas poseedoras de vitaminas y minerales que pueden ejercer efectos inmunomoduladores, así como distintos estudios recientes intentan verificar posibles efectos preventivos frente al SARS-CoV-2 por parte de algunas drogas vegetales como el bulbo de Allium sativum L. (ajo), el bulbo de Allium cepa L. (cebolla), el rizoma de Curcuma longa L. o la corteza de Uncaria tomentosa (Will.) DC.
Conclusiones: Aunque algunas plantas han demostrado su acción sobre el sistema inmune, aún son necesarias más investigaciones que permitan incrementar el conocimiento sobre las distintas propiedades y mecanismos implicados en la actuación sobre el sistema inmune.
Hipocalcemia posterior a tiroidectomía total: Análisis de dosis para suplemento rutinario profiláctico
Authors: Gómez Carlos Andrés , Casallas-Cristancho Daniela , Amaya-Nieto Javier Antonio , Rojas-Zambrano Thomas , Pinillos-Navarro Pilar Carola , Zuñiga-Pavia Sergio Fabián , Buitrago-Gutiérrez Giancarlo 
Published: March 2022

Introducción. La hipocalcemia es la complicación más frecuente de la tiroidectomía. La profilaxis con calcio/ calcitriol es una alternativa costo-efectiva, sencilla y expedita para disminuir esta situación, sin alterar la función paratiroidea residual. Lo que no está claro es si hay superioridad de una dosis frente a otra, por lo que el objetivo de este estudio fue evaluar el comportamiento entre diferentes esquemas de profilaxis para hipocalcemia.
Métodos. Estudio de cohorte retrospectivo de adultos operados en un hospital de cuarto nivel, entre febrero de 2017 y diciembre de 2020. Se calculó la tasa de síntomas, la hipocalcemia e hipercalcemia bioquímica en el control postquirúrgico durante las siguientes dos semanas. Se hizo análisis bivariado y multivariado entre dosis de calcio/ calcitriol, otros factores asociados y los desenlaces mencionados.
Resultados. Se incluyeron 967 pacientes. El 10 % presentaron síntomas. No hubo diferencias significativas en el calcio sérico del control posquirúrgico entre los grupos con distintas dosis de calcio. La dosis de carbonato de calcio >3600 mg/día y el calcio en las primeras 24 horas de cirugía se asociaron a la presencia de síntomas. La dosis de calcitriol <1 mcg/día y el bocio aumentaron el riesgo de hipocalcemia bioquímica, mientras que la dosis de 1,5 mcg/día lo disminuyó. Ninguna variable evaluada se asoció a hipercalcemia bioquímica.
Conclusiones. Teniendo en cuenta los resultados observados con las dosis de calcio y calcitriol, sugerimos iniciar la profilaxis con un esquema de 3600 mg/día de carbonato de calcio y 1,5 mcg/día de calcitriol. Sin embargo, esta dosis debe modificarse en situaciones como bocio o calcio sérico temprano anormal, que fueron las variables asociadas a mayor riesgo en nuestro estudio.
Peningkatan Produktivitas Mesin Adroit S-90 Dengan Pendekatan Nilai Overall Equipment Effectiveness (OEE) Pada Produksi Tissue (Studi Kasus di PT. Etica Sari Pratama Tangerang)
Authors: Hartono Hartono , Hadi Lukman 
Published: March 2022

PT. Etica Sari Pratama is an industry engaged in the health industry, namely wet wipes. The problems currently experienced at PT. Etica Sari Pratama is the result of low productivity, during the wet tissue production process which results in decreased production. Improvements are made to increase the productivity results on the production line. Thus, the above problems must be immediately followed up, so that productivity results can achieve results according to predetermined targets by evaluating the performance of production facilities at the company's Adroit S-90 machine is causing production to be interrupted or stopped. Therefore, an analysis of the factors resulting from decreased productivity is carried out. Improvements must be made to increase productivity. And knowing the results of productivity, problem solving is done using the Overall Equipment Effectiveness, fishbone and why-why analysis method. It can be seen that after making improvements to the comparative data from January to June the productivity had an average value of 78% and after making improvements from July to December it had an average value of 97%. Has an increase of 19%. Keywords: production line, productivity, overall equipment effectiveness, why-why analysis, fishbone.
Post-Traumatic Stress Disorder: Causes and Management in Ravi Thapaliya’s Echoes of Pain
Authors: Khadka Thir Bahadur 
Published: March 2022

Morbid human instinct and revenge psychology can lead a person to torture others with massive pain often pushing their lives into post-traumatic stress disorder which, however, can be managed with careful medicinal treatment, family support and elimination of the causes of disorder itself. Based on library research, consulting relevant archived documents supportive for analyzing the novel, this study employs the theory of trauma particularly drawing upon Caruth, Capra, Fish, Albucher and Liberzon who elaborate multiple aspects of the theory including the creation and elimination of psychic disorder. The findings show how a police interrogator tortures the suspects and enjoys at their pain in guidance of his revenge psychology developed years back when he was a street boy. The successful treatment of disorder shows how properly caring and loving the patients instead of creating distance, bringing them under proper treatment instead of isolating them and setting the things in right order instead of overlooking the causes can bring its proper management, thereby bringing the patients’ lives into right track and regular rhythm that anybody can implement for managing such disorders.
NEGARA: KEADAAN SUATU MASYARAKAT BERDASARKAN IDEOLIGI YANG DIANUTNYA
Authors: Mohtar Tarmila , Dewantara Jagad Aditya 
Published: March 2022

AbstrakIdeologi adalah suatu konsep pemikiran yang mencakup kumpulan gagasan, ide, keyakinan dan kepercayaan yang menjadi dasar terkait kehidupan manusia yang sifatnya menyeluruh dan terstruktur yang menyangkut kehidupan masyarakat dalam berbagai bidang dan bertujuan untuk mencapai tujuan atau cita-cita bersama dalam kehidupan berbangsa dan bernegara. Setiap ideologi mempunyai karakteristik tersendiri dan ideologi ini juga menjadi penentu dari keadaan suatu masyarakat oleh suatu negara. oleh karena itu penulis dalam kepenulisan ini akan membahas mengenai keadaan suatu masyarakat berdasarkan ideologi yang dianutnya. Hal tersebut dikarenakan setiap ideologi yang dianut mencerminkan keadaan suatu masyarakat yang berbeda. Dengan mambahas ini maka kita akan mengetahui seperti apa suatu masyarakat atau negara yang menganut ideologi tersebut dan tulisan ini akan membahas terkait negara berdasarkan ideologi Anarkisme, komunisme, dan Pancasila. Adapun hasil yang didapat dari tulisan ini adalah dimana anarkisme, komunisme dan Pancasila merupakan ideologi yang berbanding terbalik dan mempunyai perbedaan yang mendasar dan hal ini menciptakan keadaan suatu masyarakat yang sangat berbeda. Dimana sebenarnya setiap ideologi bertujuan untuk kebaikan rakyatnya hanya saja dalam pergerakan yang menyimpang membuat ideologi tersebut dipandang buruk.Kata kunci: Negara, Ideologi, Anarkisme, Komunisme, Pancasila AbstractIdeology is a concept of thought that includes a collection of ideas, ideas, beliefs and beliefs that form the basis for human life that is comprehensive and structured which involves people's lives in various fields and aims to achieve common goals or ideals in the life of the nation and state. Each ideology has its own characteristics and this ideology is also a determinant of the state of a society by a state. Therefore, the author in this paper will discuss the state of a society based on the ideology it adheres to. This is because each ideology adopted reflects the state of a different society. By discussing this, we will find out what a society or country that adheres to this ideology looks like and this paper will discuss the state based on the ideology of Anarchism, Communism, and Pancasila. The results obtained from this paper are where anarchism, communism and Pancasila are ideologies that are inversely proportional and have fundamental differences and this creates a very different state of society. Where in fact every ideology aims for the good of its people, only in a deviant movement makes the ideology seen as bad.Keywords: State, Ideology, Anarchism, Communism, Pancasila
Comparative Evaluation of Using Intranasal Desmopressin, Parenteral Diclofenac or their Combination in the Management of Acute Renal Colic Pain in Iraqi Patients
Authors: A. Majeed Ibrahim 
Published: March 2022

There is a suggestion that an antidiuretic hormone-induced decrease in diuresis might contribute to the rapid relief of the acute pain in renal colic. This study was designed to evaluate the efficacy of desmopressin nasal spray compared with diclofenac given intramuscularly in patients with acute renal colic. The study included 75 patients randomized into three different groups; group A received desmopressin (40 Î¼g, nasal spray), group B diclofenac (75 mg) intramuscularly and group C, both desmopressin and diclofenac. Pain was assessed using a visual analogue scale (a 10-cm horizontal scale ranging from `no pain' to `unbearable pain') at baseline, 10, 20 and 30 min after administering the treatments. On admission, the pain level was the same in all three groups. At 10 min the pain decreased in all groups to a level that was not significantly different. At 20 min groups B and C had similar mean pain levels (5.8), whereas in group A it was 5.7. At 30 min, groups B and C scored 3.0 and 2.5 respectively, and group A 6.1. All three treatments were equally effective at 10 and 20 min but at 30 min there was a stabilization/slight increase in pain level in group A. In conclusion, these results indicate that desmopressin may be used to treat renal colic either alone or combined, increasing the analgesic effect of other drugs like diclofenac
Key words: renal colic, intranasal desmopressin, diclofenac
Synthesis of Schiff Bases of Benzaldehyde and Salicylaldehyde as Anti-inflammatory Agents
Authors: N. Omar Tagreed 
Published: March 2022

Three Schiff bases from Benzaldehyde and Salicylaldehyde have been synthesized (A, 1and 2) and two of them (1and 2) have been tested for anti-inflammatory activity. The p-aminobenzene sulfonamide has been synthesized from acetanilide through the addition of excess chlorosulfonic acid then concentrated ammonia solution; Schiff base of this derivative (2) exhibited good level of activity against egg-white induced edema in rat hind paw, while the other tested derivative exhibited no activity.
Key words: Schiff bases, sulfonamide derivatives, salicylaldehyde
Factors Affecting the Formulation of Carbamazepine Extended Release Tablet
Authors: H. Aziz Samer , A. Abdulrasool Alaa , A. Hussein Ahmed 
Published: March 2022

Carbamazepine is an anticonvulsant agent which acts on the central nervous system and used for the treatment of epilepsy. Carbamazepine was formulated as an oral extended release tablets using ethyl cellulose as retardant substance. Different types of tablets additives such as cellulose materials (sodium carboxymethyl cellulose and microcrystalline cellulose ), lactose, calcium phosphate and solubilizing agents ( sodium lauryl sulphate and polyethylene glycol 6000) were utilized to study their effect on the release profile of drug from ethyl cellulose matrices. It was found that sodium carboxymethyl cellulose increased the carbamazepine release and the same effect was obtained when the same amount of microcrystalline cellulose used. The result also showed that sodium lauryl sulphate greatly enhanced the release of the drug compared to polyethylene glycol 6000. Also incorporating lactose led to an increase in the release of the drug while utilization of calcium phosphate slowed down the release of the drug. The results of this study revealed that formula which composed of 4% ethyl cellulose, 5% sodium carboxymethyl cellulose, as well as 25.6% of lactose and 1% magnesium stearate is comply with United State Pharmacopea XXVIII and showed best release profile comparable to that of the brand product Tegretol CRÂ­Â­Â­Â­Â®. The shelf life was 3.6 years for the selected formula.
Key word: Carbamazepine, Ethyl cellulose, Extended release.
Strategi Pemasaran Produk Fulprotek PT. Asuransi Takaful Keluarga dan Bank Muamalat Indonesia
Authors: Ayuni Putri , Aslami Nuri 
Published: March 2022

Marketing is one of the economic sciences that has been developing for a long time, and until now marketing greatly affects the success of a company to be able to survive in market share. Therefore the company must carry out a marketing mix which also has an influence to determine the success or failure of marketing its products. If the marketing mix implemented by the company is able to market its products well, this will affect the company's goals.
Program Penurunan Angka Kematian Bayi Melalui KKN Back To Village Di Desa Jelbuk Kabupaten Jember
Authors: Tohari Achmad Ilham , Supriono Agus 
Published: March 2022

ABSTRAK Angka Kematian Bayi (AKB) adalah salah satu faktor penentu kualitas kesehatan dalam suatu negara. Tingginya AKB pada suatu negara mengindikasikan kurangnya kualitas kesehatan yang ada. Jember termasuk dalam daerah dengan kematian bayi yang tinggi yaitu 50,19 per 1000 kelahiran hidup. Pada kawasan Kecamatan Jelbuk telah ada lima kejadian kematian bayi selama Juli – Agustus 2021 dengan dua diantaranya berada pada wilayah kerja Posyandu Mawar 2A di Desa Jelbuk. Penurunan AKB di Desa Jelbuk membutuhkan bantuan dari berbagai pihak. Kegiatan pengabdian ini bertujuan untuk menurunkan angka AKB di Desa Jelbuk. Metode pengabdian berbentuk program penurunan AKB (berbasis kader kesehatan masyarakat) yang terdiri atas kegiatan penyuluhan AKB, BPJS kesehatan, dan pendampingan “Jemput Bola” imunisasi di kawasan Posyandu Mawar 2A. Lokasi pengabdian dipilih berdasarkan urgensi yang ada, yaitu dua AKB yang terjadi dalam lingkup Desa Jelbuk berada dalam kawasan kerja Posyandu Mawar 2A. Hasil dari kegiatan pengabdian berupa kader kesehatan posyandu mawar 2A dan masyarakat berhasil memahami materi AKB dan BPJS kesehatan. Anak yang diimunisasi dalam program kerja pendampingan “Jemput Bola” imunisasi berjumlah enam bayi. Kesimpulan program ini dapat meningkatkan pengetahuan kader kesehatan dan warga di Desa Jelbuk, khususnya mengenai penurunan AKB. Kata kunci: Angka Kematian Bayi, , anak, AKB, pencegahan AKB. ABSTRACT Infant Mortality Rate (IMR) is one of health quality defining factor in a country. Increased IMR indicate that the country had a poor health quality. Jember is a region that has a highest IMR about 50.19 per 1000 live birth. There were five IMR in Jelbuk district during July – August 2021 with two of them located in Posyandu Mawar 2A working area. In order to decrease the IMR, various help is needed from the stage holder. The aim of this community service is to decrease IMR in Jelbuk. The methods of this community service were arranged in several programs to decrease IMR (health cadres based) including IMR counselling, BPJS kesehatan, and “Jemput Bola” immunization in Posyandu Mawar 2A area. The community service location is based on the urgency that two of five IMR in Jelbuk is in Posyandu Mawar 2A working area. The results of this community service showed that the health cadres understand the topic about IMR and BPJS kesehatan. Total of six babies get immunization during “Jemput Bola” immunization program. The conclusion of this community service is this program may increase the knowledge of Jelbuk’s inhabitant and health cadres, specially in the scope of decreasing IMR. Keywords: Infant Mortality Rate, Infant, IMR, IMR prevention
Pendampingan Kepatuhan Protokol Kesehatan Covid-19 Klien Schizophrenia
Authors: Ibad Muhammad Rosyidul , Arfianto Muhammad Ari , Fikri Zahid 
Published: March 2022

ABSTRAKKlien dengan gangguan mental schizophrenia merupakan kelompok rentan yang harus mendapat perhatian dimasa pandemic Covid-19. Gangguan fungsi kognitif, afektif, perilaku, dan social yang dialami akan memperberat terhadap pemahaman dan perilaku patuh terhadap protocol kesehatan covid-19. Tujuan dari pengabdian ini adalah untuk melakukan pendampingan agar pasien gangguan skizophrenia patuh terhadap protocol kesehatan covid-19. Pelaksanaan proses pendampingan dimulai dari perizinan, persiapan program, penyamaan persepsi dengan perawat dan petugas sosial, implementasi psikodrama, serta evaluasi dengan menggunakan uji Mann Whiteney. Dari hasil evaluasi dengan menggunakan General adherence to the COVID-19 preventive yang kemudian diolah menggunakan SPSS Versi 20. Didapatkan bahwa terdapa perbedaan yang sangat signifikan pada kelompok yang mendapat perlakuan psikodrama 4 sesi. Terdapat perbedaan sebelum dilakukan pendampingan kepatuhan protocol dan setelah pendampingan protokol kesehatan covid-19 ini karena prosedur pelaksanaan yang mudah serta pasien mendapatkan contoh secara langsung dari narasi yang dibacakan dan dapat melakukan improvisasi sehingga perilakumenjadi lebih adaptif. Kata Kunci: Covid-19, Kepatuhan, Protokol Kesehatan, Schizophrenia ABSTRACTSchizophrenic clients are a vulnerable group that must receive attention during the Covid-19 pandemic. Disturbances in cognitive, affective, behavioral, and social functions experienced will exacerbate understanding and compliance with the COVID-19 health protocol. The purpose of this service is to provide assistance so that patients with schizophrenia disorders comply with the COVID-19 health protocol. The implementation of the mentoring process starts from licensing, program preparation, sharing perceptions with nurses and social workers, implementing psychodrama, and evaluating using the Mann Whiteney test. From the results of the evaluation using General adherence to the COVID-19 preventive which was then processed using SPSS Version 20. It was found that there was a very significant difference in the group receiving 4 sessions of psychodrama treatment. There are differences before the protocol compliance assistance is carried out and after the Covid-19 health protocol assistance is due to the easy implementation procedure and the patient gets direct examples from the narratives that are read and can improvise so that behavior becomes more adaptive. Key Word: Covid-19, Compliance, Health Protocol, Schizophrenia
Pendampingan Ibu Hamil Resiko Tinggi Melalui Continuity Of Care (COC) Di Puskesmas Pembantu Karot Kabupaten Manggarai
Authors: Trisnawati Reineldis Elsidianastika , Halu Silvia A.N. , Manggul Makrina S. , Nanur Fransiska N. , Wati Bernadeta 
Published: March 2022

ABSTRAK Kehamilan merupakan suatu hal yang fisiologis tetapi ada beberapa masalah yang dapat menyertai kehamilan yaitu penyebab langsung dan tidak langsung. Salah satu masalah kehamilan dengan penyebab tidak langsung adalah usia ibu >35 tahun yang sangat berisiko bagi ibu dan janin seperti perdarahan, kelahiran prematur dan berat badan lahir rendah. Kegiatan pendampingan ini bertujuan untuk dapat memberikan asuhan kebidanan secara berkesinambungan (Continuity Of Care) pada Ny M dengan kehamilan risiko tinggi. Continuity Of Care dapat dilakukan selama kehamilan, persalinan, nifas dan Keluarga Berencana (KB). Pengumpulan data dapat dilakukan melalui wawancara, observasi langsung dan studi dokumen. Dari kegiatan pendampingan yang dilakukan pada Nyonya M, selama hamil, masa nifas dan neonatus, berjalan normal, tidak ditemukan adanya komplikasi. Ibu juga mengikuti program KB dengan jenis kontrasepsi yang digunakan adalah IUD/Spiral. Kata Kunci: resiko tinggi, kehamilan, persalinan, nifas, KB ABSTRACT Pregnancy is a physiological thing but there are several problems that can accompany pregnancy, namely direct and indirect causes. One of the pregnancy problems with indirect causes is maternal age >35 years which is very risky for the mother and fetus such as bleeding, premature birth and low birth weight. This mentoring activity aims to be able to provide continuous midwifery care (Continuity Of Care) to Mrs.M with a high-risk pregnancy. Continuity Of Care can be done during pregnancy, childbirth, postpartum and family planning. Data collection can be done through interviews, direct observation and document studies. From the mentoring activities carried out for Mrs. M, during pregnancy, the puerperium and neonates, everything went normally, no complications were found. Mothers also participate in the family planning program with the type of contraception used is the IUD/Spiral. Keywords: high risk, pregnancy, childbirth, postpartum, family planning