bluuebunny/crossref_metadata_2025_split huggingface dataset:
The future of intensive care: delirium should no longer be an issue
Authors: Kotfis Katarzyna , van Diem-Zaal Irene , Williams Roberson Shawniqua , Sietnicki Marek , van den Boogaard Mark , Shehabi Yahya , Ely E. Wesley 
Published: July 2022

AbstractIn the ideal intensive care unit (ICU) of the future, all patients are free from delirium, a syndrome of brain dysfunction frequently observed in critical illness and associated with worse ICU-related outcomes and long-term cognitive impairment. Although screening for delirium requires limited time and effort, this devastating disorder remains underestimated during routine ICU care. The COVID-19 pandemic brought a catastrophic reduction in delirium monitoring, prevention, and patient care due to organizational issues, lack of personnel, increased use of benzodiazepines and restricted family visitation. These limitations led to increases in delirium incidence, a situation that should never be repeated. Good sedation practices should be complemented by novel ICU design and connectivity, which will facilitate non-pharmacological sedation, anxiolysis and comfort that can be supplemented by balanced pharmacological interventions when necessary. Improvements in the ICU sound, light control, floor planning, and room arrangement can facilitate a healing environment that minimizes stressors and aids delirium prevention and management. The fundamental prerequisite to realize the delirium-free ICU, is an awake non-sedated, pain-free comfortable patient whose management follows the A to F (A–F) bundle. Moreover, the bundle should be expanded with three additional letters, incorporating humanitarian care: gaining (G) insight into patient needs, delivering holistic care with a ‘home-like’ (H) environment, and redefining ICU architectural design (I). Above all, the delirium-free world relies upon people, with personal challenges for critical care teams to optimize design, environmental factors, management, time spent with the patient and family and to humanize ICU care.
Natural association of the entomopathogenic nematode Heterorhabditis indica (Rhabditida: Heterorhabditidae) from the Philippines with the non-symbiotic bacterium Ochrobactrum anthropi (Proteobacteria: Brucellaceae)
Authors: Leonar April Lyn , Nimkingrat Prakaijan , Aryal Sitaram , Martinez Joey Genevieve , Bhat Aashaq Hussain , Sumaya Nanette Hope 
Published: July 2022

Abstract
Background
Entomopathogenic nematodes of the genera Heterorhabditis and Steinernema are widely used as biocontrol agents against diverse insect pests. Their association with symbiont bacteria is found to be the primary cause of insect mortality. The present study reported a comprehensive characterization of a local Philippine EPN isolate using congruent morpho-taxometrical and molecular data and the associated bacterium in the infective dauer juveniles.

Results
Using an insect-baiting technique, a nematode isolate labeled F2H was recovered from the sandy soils in the coastal area of southern Philippines. Based on morphology and morpho-taxometrics, the F2H isolate collected from Iligan City was identified as Heterorhabditis indica. Analysis of the ITS region of rDNA revealed the highest sequence match to H. indica. The sequences of the bacterial 16S rDNA gene showed that the symbiont of H. indica presented 100% similitude with the sequences of Ochrobactrum anthropi. Further, pairwise alignment and phylogenetic analysis demonstrated that O. anthropi, O. lupini and O. cytisi shared 100% similarity and form a monophyletic clade. These strains have not presented any differences in the phylogenetic and 16S rDNA data, and O. lupini and O. cytisi should be considered a later heterotypic synonym of O. anthropi.

Conclusions
The description of H. indica-O. anthropi association was the first report in the Philippines. This provides additional account and collection of naturally isolated EPN-bacteria, contributing to limited knowledge on its diversity in the Philippines, which can be utilized in the biocontrol of pests after further comprehensive assessments.
Potential of selected plant essential oils in management of Sitophilus oryzae (L.) and Rhiyzopertha dominica (F.) on wheat grains
Authors: Abo Arab Raafat Badr , El-Tawelah Nariman Mohamed , Abouelatta Ahmed Mohamed , Hamza Amal Moustafa 
Published: July 2022

AbstractBackgroundTwo plant essential oils, basil (Ocimum basilicumL.) and petitgrain mandarin (Citrus reticulateL.), and one pyrethroid chemical insecticide, lambda-cyhalothrin, were evaluated against two of the most important stored product insect pests,Sitophilus oryzaeandRhyzopertha dominica, on wheat grains under laboratory conditions using mixing with feeding method. The effect of the tested materials was studied on F1progeny of the tested insects. Chemical components of the oils and side effects on protein content percentage, total carbohydrates of wheat grain and germination were investigated.ResultsResults obtained showed that the two oils had a good insecticidal effect on the tested insects. Petitgrain mandarin oil was the premier. The two tested essential oils reduced the F1progeny. In addition, the progressive of periods after storage (0–180 days) significantly reduced protein content (%) and total carbohydrates compared to control. Nearly, there were no significant differences between treatments (LC50and LC95) of basil and (petitgrain) mandarin on the studied parameters. Germination percentages from 0 to 180 days post-storage had slight differences between control and treatments for oils. Lambda-cyhalothrin significantly reduced germination, especially with the LC95from 60 to 180 days. Chemical analysis demonstrated that the main components of basil oil were linalool, eugenol, methyl chavicol and cani, while the main components of petitgrain mandarin oil were dimethyl panthenalate, α-terpinene, β-cinem and citral accounting for 71.1 and 95% of the two oils, respectively.ConclusionsThe results obtained proved that the two tested plant essential oils had an obvious role in suppressing the activity of the two tested insects and can be used in an integrated pest management program. The two tested essential oils can be used as green pesticides and can be effective alternatives for chemical pesticides.
Relevance of Bone Marrow Biopsies for Response Assessment in US National Cancer Institute National Clinical Trials Network Follicular Lymphoma Clinical Trials
Authors: Rutherford Sarah C. , Yin Jun , Pederson Levi , Perez Burbano Gabriela , LaPlant Betsy , Shadman Mazyar , Li Hongli , LeBlanc Michael L. , Kenkre Vaishalee P. , Hong Fangxin , Blum Kristie A. , Dockter Travis , Martin Peter , Jung Sin-Ho , Grant Barbara , Rosenbaum Cara , Ujjani Chaitra , Barr Paul M. , Unger Joseph M. , Cheson Bruce D. , Bartlett Nancy L. , Kahl Brad , Friedberg Jonathan W. , Mandrekar Sumithra J. , Leonard John P. 
Published: July 2022

PURPOSE Bone marrow biopsies (BMB) are performed before/after therapy to confirm complete response (CR) in patients with lymphoma on clinical trials. We sought to establish whether BMB add value in assessing response or predict progression-free survival (PFS) or overall survival (OS) outcomes in follicular lymphoma (FL) subjects in a large, multicenter, multitrial cohort. METHODS Data were pooled from seven trials of 580 subjects with previously untreated FL through Alliance for Clinical Trials in Oncology (Alliance) and SWOG Cancer Research Network (SWOG) completing enrollment from 2008 to 2016. RESULTS Only 5/580 (0.9%) had positive baseline BMB, CR on imaging, and subsequent positive BMB ( P < .0001). Therefore, BMB were irrelevant to response in 99% of subjects. A sensitivity analysis of 385 FL subjects treated on an Eastern Cooperative Oncology Group study was included. In the Eastern Cooperative Oncology Group cohort, 5/385 (1.3%) had BMB that affected response assessment. Since some subjects do not undergo confirmatory BMB, we performed a landmark survival analysis from first radiologic CR with data from 580 subjects from Alliance and SWOG. Of subjects with CR on imaging (n = 187), PFS and OS were not significantly different among those with negative BMB to confirm CR (n = 47) versus those without repeat BMB (n = 140; PFS: adjusted hazard ratio, 1.10, 95% CI, 0.62 to 1.94, log-rank P = .686; OS: hazard ratio, 0.59, 95% CI, 0.23 to 1.53, log-rank P = .276). CONCLUSION We conclude that BMB add little value to response assessment in subjects with FL treated on clinical trials and we recommend eliminating BMB from clinical trial requirements. BMB should also be removed from diagnostic guidelines for FL except in scenarios in which it may change management including confirmation of limited stage and assessment of cytopenias. This would reduce cost, patient discomfort, resource utilization, and potentially remove a barrier to trial enrollment.
Efficacy of Isothermic Conditioning over Military-Based Heat Acclimatization and Interval Training in Tropical Native Males
Authors: TAN SHAWN CHEE CHONG , ANG WEE HON , LIM LOUISA SI XIAN , LOW IVAN CHERH CHIET , LEE JASON KAI WEI 
Published: July 2022

ABSTRACT

Purpose
We compared the effectiveness of three field-based training programs, namely military-based heat acclimatization (MHA), isothermic conditioning (IC) and interval training (IT), in inducing physiological adaptations in tropical natives.

Methods
Fifty-one untrained tropical native males (mean ± standard deviation: age, 25 ± 2 yr; body mass index, 23.6 ± 3.2 kg·m−2; body fat, 19% ± 5%; 2.4-km run time, 13.2 ± 0.9 min) donned the Full Battle Order attire (22 kg) and performed a treadmill route march heat stress test in an environmental chamber (dry bulb temperature, 29.9°C ± 0.5°C; relative humidity, 70% ± 3%). Heat stress tests were conducted before (PRE) and after (POST) a 2-wk training intervention consisting of either a MHA (n = 17, 10 sessions of military-based heat acclimatization), IC (n = 17, 10 sessions with target gastrointestinal temperature (T
gi) ≥ 38.5°C) or IT (n = 17, six sessions of high-intensity interval training) program. T
gi, HR, mean weighted skin temperature (T
sk), physiological strain index (PSI) and thigh-predicted sweat sodium concentration ([Na+]) were measured and analyzed by one-factor and two-factor mixed design ANOVA with a 0.05 level of significance.

Results
Field-based IC induced a greater thermal stimulus than MHA (P = 0.029) and IT (P < 0.001) during training. Reductions in mean exercise T
gi (−0.2°C [−0.3°C, 0.0°C]; P = 0.009), PSI (−0.4 [−0.7, −0.1]; P = 0.015) and thigh-predicted sweat [Na+] (−9 [−13, −5 mmol·L−1]; P < 0.001) were observed in IC but not MHA and IT (all P > 0.05). Resting HR (MHA, −4 bpm [−7, 0 bpm]; P = 0.025; IC, −7 bpm [−10, −4 bpm]; P < 0.001; IT, −4 bpm [−8, −1 bpm]; P = 0.008) and mean exercise HR (MHA, −4 [−8, 0 bpm]; P = 0.034; IC, −11 bpm [−15, −8 bpm]; P < 0.001, IT = −5 bpm [−9, −1 bpm]; P = 0.012) were lowered in all groups after training. Isothermic conditioning elicited a greater attenuation in mean exercise HR and thigh-predicted sweat [Na+] relative to MHA (both P < 0.05). No between-group differences were observed when comparing MHA and IT (all P > 0.05).

Conclusions
Isothermic conditioning induced a more complete heat-adapted phenotype relative to MHA and IT. Interval training may serve as a time efficient alternative to MHA.
An exploration of the consequences of, and coping with loneliness in an ageing intellectual disability population
Authors: Wormald Andrew , McCallion Philip , McCarron Mary 
Published: July 2022

Background: Loneliness has been associated with increased hypervigilance and sad passivity. The physiological and psychological reactions of people with an intellectual disability to loneliness have never been investigated. Therefore, this research aims to explore the outcomes of loneliness for an ageing intellectual disability population. Methods: In Ireland, data from a nationally representative data set of people aged over 40 years with an intellectual disability (N=317) was applied to a social environment model that describes the effects of loneliness in five pre-disease pathways which are: health behaviours, exposure to stressful life events, coping, health and recuperation. The data was tested through chi-squared, ANCOVA and binary logistic regression. Results: Being lonely predicted raised systolic blood pressure (A.O.R=2.051, p=0.039), sleeping difficulties (AOR=2.526, p=0.002) and confiding in staff (AOR=0.464 p=0.008). Additionally, participants who did 10 to 20 minutes of exercise daily (moderate activity) had significantly higher loneliness scores than those who did not (F=4.171, p<0.05). Conclusions: The analysis supports the concept of hypervigilance in older people with an intellectual disability but finds that the health behaviours of the lonely do not differ from the not lonely. Future research needs to investigate the longitudinal relationships between loneliness and health
THE USE OF A SPECIFIC GSRS QUESTIONNAIRE FOR DIFFERENTIAL DIAGNOSIS OF DISEASES OF THE GASTROINTESTINAL TRACT
Authors: Kazarin Daniil D. , Shklyaev Aleksey E. , Bolkiseva Polina S. , Petrova Ekaterina V. 
Published: July 2022

The pathology of the gastrointestinal tract occupies one of the leading places in the structure of the general morbidity of the population. Despite modern diagnostic methods, their prevalence is constantly increasing. Among the diseases of the gastroenterological profile, the most common are chronic pancreatitis, gastric ulcer and duodenal ulcer, hepatitis and cirrhosis of the liver, as well as chronic intestinal diseases.
Purpose. To assess the possibilities of the GSRS questionnaire as a method for differential diagnosis of diseases of various organs of the gastrointestinal tract.
Materials and methods. A study of the symptoms of 91 patients with gastrointestinal diseases was carried out using a specific GSRS questionnaire. Also, to verify the diagnoses, laboratory (complete and biochemical blood tests, complete feces and urine analyzes) and endoscopic (EGDS and video colonoscopy) research methods were carried out.
Results. In the course of the study, the patients were divided into three groups according to the main diagnosis. It was noted that all groups were significantly different in terms of abdominal pain syndrome (AP) and reflux syndrome (RS), as well as the overall score of the GSRS questionnaire. Laboratory data were consistent with the clinical picture of the disease.
Conclusion. Shows the importance of using the GSRS questionnaire as a method of approximate differential diagnosis of diseases of various parts of the gastrointestinal tract. The necessity of its joint use with laboratory – instrumental methods in the examination of patients is noted. Thus, an integrated approach will improve the efficiency of the quality of primary health care provided.
BIG DATA APPLICATION IN THE NEYMAN-PEARSON REGRESSION AND DEEP BERNOULLI AND BOLTZMANN FOR IOT BASED SOIL QUALITY PREDICTION
Authors: Balaji G. , Vijayakumar P. 
Published: July 2022

Purpose. The aim of the work is to enhance the soil quality prediction accuracy and time by using feature selection and classification-based model.
Background. Soil quality analysis was handled based on the farmer’s first-hand data mining competence and with the world population expected to increase exponentially (i.e., big data), erratic changes in climate have started influencing soil capitulates incorrectly. Big data is employed used to examine the large amount of dataset for soil quality analysis. It is helps to address a lot of new and significant farming decisions and issue. Soil quality analysis depends on fertility of the soil. By soil quality analysis accuracy prediction is very crucial for practical utilization of resources. But, the existing data mining techniques failed to select the correct crop based on the soil and environmental features.
Material and methods. The study presents the data mining techniques based on smart and efficient soil quality prediction for agriculture development. In our work, first, linear regression and the Neyman-Pearson correlation-based feature selection model is employed to obtain the computationally efficient and relevant features. Next, an enhanced deep learning model called deep Bernoulli and Boltzmann IoT-based soil quality prediction is designed to classify the complex soil features with better sensitivity and specificity.
Results. Experimental results obtained confirmed the performance and reliability of the proposed method. The result evaluations are carried out on the basis of the prediction accuracy, prediction time, sensitivity and specificity.
Conclusion. The result shows that the NPR-DBB method achieves better results than the state-of-the-art methods.
Graves-Basedow disease treated by complementary medicine leading to severe thyrotoxicosis – a case report
Authors: Sapuła Klaudia , Gołacki Jakub , Marczak Aleksandra , Hordejuk Michalina , Iwaszko-Sochal Klaudyna 
Published: July 2022

Graves' disease is a common cause of hyperthyroidism. Inadequate treatment or non-compliance can lead to serious complications, including thyroid storm.
We present the case of a 22-year-old woman who had been treated with antithyroid drugs (ATD) for almost 7 years, however decided to suspend conventional treatment and turned towards complementary and alternative medicine methods. Following the bioenergotherapist's advice, she began taking Lugol’s solution (LS) at a dose of 30 drops per day. After about one month of such therapy, the patient was urgently admitted to the Emergency Department with thyrotoxicosis with a high risk of thyroid storm development. With the implementation of intensive thyrostatic treatment and steroid therapy, euthyroidism was successfully restored.
Complex treatment of invasive corticotropic pituitary macroadenoma - Case report
Authors: Obel Michał , Nowicka Emilia , Dzikowski Piotr , Pietrzak Zofia , Stefaniak Martyna , Obel Ewa 
Published: July 2022

Introduction: Cushing's disease is a hypercortisolemic state caused by the excess secretion of corticotropin by the pituitary adenoma. Cushing's disease is diagnosed on the basis of clinical and laboratory signs of hypercortisolemia and the presence of an MRI pituitary adenoma. Pituitary surgery represents the first-line therapy, but it is non-curative in one third of patients, requiring additional treatments. Second-line treatments include pharmacotherapy, pituitary radiotherapy and bilateral adrenalectomy.
Case report: A 57-year-old patient with clinical symptoms of hypercortisolemia was admitted to the Endocrinology Clinic due to dizziness and headache. Laboratory tests and MRI confirmed Cushing's disease caused by invasive pituitary macroadenoma. The tumor was not completely resected through the sphenoid sinus. Disease symptoms were remitted and hormone levels were stabilized. After 2 years, the underlying disease was relapsed. A second tumor removal operation was performed. The tumor was incompletely removed. The disease has progressed.. The patient was referred for stereotaxic CyberKnife radiotherapy.
Conclusion: Cushing's disease should be diagnosed and treated in a specialized endocrinology center, and the success of treatment depends on a multidisciplinary team of physicians consisting of an endocrinologist, neurosurgeon and neuroradiologist.About 50% of untreated patients die within 5 years of the disease due to complications of hypercortisolemia. Surgical treatment is effective in the case of microadenomas, while in the case of macroadenomas, it may turn out to be ineffective when the tumor is highly invasive. If subsequent surgeries are unsuccessful, treatment with radiotherapy or pharmacotherapy should be given.
Differential rater function over time (DRIFT) during student simulations
Authors: Diebel Sebastian , Boissonneault Eve , Perreault Luc , Lapierre René 
Published: July 2022

Background The field of paramedicine continues to advance in scope. Simulation training is frequently used to teach and evaluate students. Simulation examinations are often evaluated using a standardised global rating scale (GRS) that is reliable and valid. However, differential rater function over time (DRIFT) has not been evaluated when using the GRS during simulations. Aims This study aimed to assess if DRIFT arises when applying the GRS. Methods Data were collected at six simulation evaluations. Raters were randomly assigned to evaluate several students at the same station. Each station lasted 12 minutes and there was a total of 11 stations. A model to test DRIFT scores was created and was tested against both a leniency and perceptual model. Findings Of the models explored, one that included students, the rater, and the dimensions had the greatest evidence (–3151 Bayes factors). This model was then tested against leniency (K=–9.1 dHart) and perceptual models (K=–7.1 dHart). This suggests a substantial finding against DRIFT; however, the tested models used a wide parameter so the possibility of a minor effect is not fully excluded. Conclusion DRIFT was not found; however, further studies with multiple centres and longer evaluations should be conducted.
Laser-induced fluorescence of PO-photofragments of dimethyl
methylphosphonate
Authors: Bobrovnikov Sergei M. , Gorlov Evgeny V. , Zharkov Viktor I. 
Published: July 2022

The paper presents the results of calculating the absorption spectrum of a phosphorus monoxide (PO) molecule corresponding to the

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