bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal Strategies for Colorectal Cancer Screening
Authors: Jain Shailavi , Maque Jetrina , Galoosian Artin , Osuna-Garcia Antonia , May Folasade P. 
Published: March 2022

Opinion statementColorectal cancer (CRC) imposes significant morbidity and mortality, yet it is also largely preventable with evidence-based screening strategies. In May 2021, the US Preventive Services Task Force updated guidance, recommending screening begin at age 45 for average-risk individuals to reduce CRC incidence and mortality in the United States (US). The Task Force recommends screening with one of several screening strategies: high-sensitivity guaiac fecal occult blood test (HSgFOBT), fecal immunochemical test (FIT), multi-target stool DNA (mt-sDNA) test, computed tomographic (CT) colonography (virtual colonoscopy), flexible sigmoidoscopy, flexible sigmoidoscopy with FIT, or traditional colonoscopy. In addition to these recommended options, there are several emerging and novel CRC screening modalities that are not yet approved for first-line screening in average-risk individuals. These include blood-based screening or “liquid biopsy,” colon capsule endoscopy, urinary metabolomics, and stool-based microbiome testing for the detection of colorectal polyps and/or CRC. In order to maximize CRC screening uptake in the US, patients and providers should engage in informed decision-making about the benefits and limitations of recommended screening options to determine the most appropriate screening test. Factors to consider include the invasiveness of the test, test performance, screening interval, accessibility, and cost. In addition, health systems should have a programmatic approach to CRC screening, which may include evidence-based strategies such as patient education, provider education, mailed screening outreach, and/or patient navigation, to maximize screening participation.
Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study
Authors: Endepols Heike , Anglada-Huguet Marta , Mandelkow Eckhard , Schmidt Yannick , Krapf Philipp , Zlatopolskiy Boris D. , Neumaier Bernd , Mandelkow Eva-Maria , Drzezga Alexander 
Published: March 2022

Abstract

Cerebral glucose hypometabolism is a typical hallmark of Alzheimer’s disease (AD), usually associated with ongoing neurodegeneration and neuronal dysfunction. However, underlying pathological processes are not fully understood and reproducibility in animal models is not well established. The aim of the present study was to investigate the regional interrelation of glucose hypometabolism measured by [18F]FDG positron emission tomography (PET) with various molecular targets of AD pathophysiology using the PET tracers [18F]PI-2620 for tau deposition, [18F]DPA-714 for TSPO expression associated with neuroinflammation, and [18F]UCB-H for synaptic density in a transgenic tauopathy mouse model. Seven-month-old rTg4510 mice (n = 8) and non-transgenic littermates (n = 8) were examined in a small animal PET scanner with the tracers listed above. Hypometabolism was observed throughout the forebrain of rTg4510 mice. Tau pathology, increased TSPO expression, and synaptic loss were co-localized in the cortex and hippocampus and correlated with hypometabolism. In the thalamus, however, hypometabolism occurred in the absence of tau-related pathology. Thus, cerebral hypometabolism was associated with two regionally distinct forms of molecular pathology: (1) characteristic neuropathology of the Alzheimer-type including synaptic degeneration and neuroinflammation co-localized with tau deposition in the cerebral cortex, and (2) pathological changes in the thalamus in the absence of other markers of AD pathophysiology, possibly reflecting downstream or remote adaptive processes which may affect functional connectivity. Our study demonstrates the feasibility of a multitracer approach to explore complex interactions of distinct AD-pathomechanisms in vivo in a small animal model. The observations demonstrate that multiple, spatially heterogeneous pathomechanisms can contribute to hypometabolism observed in AD mouse models and they motivate future longitudinal studies as well as the investigation of possibly comparable pathomechanisms in human patients.
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space
Authors: Zidar Nina , Gale Nina 
Published: March 2022

AbstractIn this article, we review the chapter on tumors of the larynx, hypopharynx, trachea and parapharyngeal space in the new edition of the WHO book, focusing on the new developments in comparison to the previous edition. Squamous cell carcinoma (SCC) and its variants are by far the most common malignancies at these locations, with very limited new insights. The most important is the introduction of new targeted treatment—checkpoint inhibitors, with a new task for pathologists, who may help to predict the response to treatment by analyzing the expression of targeted proteins in biopsy samples. Precancerous lesions remain a controversial topic and, similarly to other organs, it is acceptable to use the terms “dysplasia” or “squamous intraepithelial lesion” (SIL), but there is a slight difference between low-grade dysplasia and low-grade SIL: in the former, mild atypia must be present, while the latter also includes hyperplastic epithelium without atypia. Two approaches have been proposed: a two-tiered system with low- and high-grade dysplasia/SIL and a three-tiered system with an additional category, carcinoma in situ. We are still searching for reliable diagnostic markers to surpass the subjectivity in biopsy diagnosis, with a few potential candidate markers on the horizon, e.g., stem cell markers. Other tumors are rare at these locations, e.g., hematolymphoid, neuroendocrine and salivary gland neoplasms, and are no longer included in Chapter 3. They must be diagnosed according to criteria described in specific chapters. The same holds true for soft tissue tumors, with the exception of cartilaginous neoplasms, which are still included in Chapter 3.
Stable Carbon and Nitrogen Isotope Composition in Suspended Particulate Matter Reflects Seasonal Dynamics of Phytoplankton Assemblages in the Gulf of Riga, Baltic Sea
Authors: Tunēns Juris , Aigars Juris , Poikāne Rita , Jurgensone Iveta , Labucis Atis , Labuce Astra , Liepiņa-Leimane Ineta , Buša Lauma , Vīksna Arturs 
Published: March 2022

AbstractThe ratio of stable carbon and nitrogen isotopes in the suspended particulate matter has been widely used to study processes occurring in the marine ecosystem. At the same time, the signals provided by isotope ratios in coastal ecosystems can be difficult to interpret, due to several, often contradictory processes taking place simultaneously. In this study, we hypothesized that the carbon and nitrogen isotopic variation is predominantly affected by seasonally occurring phytoplankton species succession in the Gulf of Riga, Baltic Sea. Cyclical seasonal patterns were observed for carbon and nitrogen isotopic compositions of both SPM and phytoplankton data. Enrichment of heavy isotopes in the Gulf of Riga took place during spring phytoplankton bloom (from on average between + 7.1 and + 8.8 ‰, and between − 23.7 and − 21.9 ‰ for δ15N and δ13C, respectively) and pooled at significantly lower values (from + 3.1 to + 5.1 ‰ and from − 28.7 to − 25.1 ‰ for δ15N and δ13C, respectively) for the rest of the year. At the same time, the spatial gradient of isotope ratios was sporadic and inconclusive. The results showed that terrestrial and anthropogenic input to particulate matter is negligible from spring to autumn. Multivariate analysis revealed that the observed seasonal variability was indeed driven by variation in phytoplankton species composition. The diatoms, dinoflagellates, and the ciliate Mesodinium rubrum facilitated enrichment of 15N and 13C in spring. In contrast, atmospheric nitrogen fixation by cyanobacteria and the assimilation of their released nutrients by other organisms resulted in lower δ15N values during summer. This variability requires careful considerations for conducting food web studies in temperate coastal and estuarine environments during high phytoplankton biomass periods.
Thrive during a crisis: the role of digital technologies in fostering antifragility in small and medium-sized enterprises
Authors: Corvello Vincenzo , Verteramo Saverino , Nocella Isabella , Ammirato Salvatore 
Published: March 2022

AbstractThe crisis triggered by the COVID-19 emergency is changing the competitive landscape by pushing companies to adapt to sudden change. Small and medium-sized enterprises (SMEs) that want to survive must innovate their business. Antifragility represents the capability of a system to absorb shocks and get better, allowing it to overcome a crisis and improve its performance. The use of digital technologies by enterprises is expected to play an important role in building antifragility. The aim of this paper is to study how digital technologies can contribute to the development of antifragility in SMEs. This study analyzed the responses to the COVID-19 pandemic crisis of six small and medium-sized enterprises located in Calabria, South of Italy. All the six enterprises have turned the crisis into a business opportunity developing new products, investing in marketing and communication, or starting new collaborations. The research identifies the factors leveraged by the investigated organizations that enabled this anti fragile behavior. They include slack financial resources, strategic agility, and relations with research institutions. The study highlights the positive impact of digital technologies in developing antifragility. Results were summarized into research propositions to be tested in future confirmatory studies. The findings of the study are useful for researchers interested in antifragility and digital technologies in SMEs. The results are also important for entrepreneurs and managers of SMEs, since they can support their decisions in terms of survival and transformation of their companies.
The Effects of Mindfulness-Based Stress Reduction on Trauma in Victims of Gun Violence: a Pilot Study
Authors: Khatib Lora , Riegner Gabriel , Dean Jon G. , Oliva Valeria , Cruanes Gael , Mulligan Beth A. , Zeidan Fadel 
Published: March 2022

Abstract
Objectives
Gun violence is a significant problem in the United States of America. Gun violence produces lifelong psychological adversity, trauma, and grief. In the face of this epidemic, efficacious therapies that assuage gun violence-based trauma and negative health are lacking.

Methods
The proposed, longitudinal pilot experiment examined the effects of an 8-week mindfulness-based stress reduction (MBSR) program on traumatized individuals as a direct consequence of gun violence. Twenty-four victims of gun violence (median age = 53 years; 21 female) completed measures of the primary outcome: trauma. Secondary outcomes were characterized as grief, depression, sleep quality, life satisfaction, and mindfulness. All assessments were administered before, after 5, and 8 weeks of MBSR training. It was hypothesized that trauma and other comorbidities would improve following MBSR. It was also predicted that outcomes would be significantly stronger from baseline to 5 weeks of MBSR training than from 5 to 8 weeks of training.

Results
Before MBSR, volunteers exhibited high levels of trauma, depression, sleep difficulty, and grief. Participation in MBSR was associated with improved trauma, depression, sleep difficulty, and life satisfaction. The most pronounced improvements in psychological disposition were exhibited within the first 5 weeks of MBSR. However, these benefits were largely preserved after completion of the course. Importantly, increases in dispositional mindfulness predicted lower trauma, complicated grief, and sleep difficulties.

Conclusions
The present findings should be interpreted with caution because they were derived from an uncontrolled, non-randomized trial. However, said findings suggest that MBSR may reduce trauma and improve overall well-being in gun violence victims.
HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway
Authors: Yuan Zhang , Xiao-wei Liu , Juan Wei , Xiu-juan Liu , Nian-yun Zhang , Lei Sheng 
Published: March 2022

AbstractFatty liver can be induced by dietary habits and lifestyle and is directly related to obesity. Although the benefits of exercise interventions for reduction of liver fat have recently been acknowledged, the underlying mechanisms remain unclear. Thus, our present study investigated the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on high-fat diet-induced hepatic lipid accumulation, and explored the role of endoplasmic reticulum (ER) stress signaling pathways. To establish an obesity model, rats were fed with a normal standard diet or a high-fat diet (45% kcal as fat). Then, both lean and obese rats were divided into three subgroups: sedentary control (LC, OC) groups, high-intensity interval training (LHI, OHI) groups, and moderated-intensity continuous training (LMI, OMI) groups (n = 10). Rats in the exercise group underwent a swimming training protocol for 8 weeks. After the experimental period, serum and liver tissues from different groups were dissected for morphological and biochemical analyses. The results showed that with HIIT and MICT interventions, body weight and serum inflammatory markers (e.g., MCP-1, IL-1β, and TNF-α) were reduced in obese rats. Interestingly, HIIT was more effective in ameliorating liver triglyceride content and enhancing mitochondrial metabolic-enzymatic activity than was MICT in obese rats. Both HIIT and MICT conferred beneficial properties through upregulating Nrf2 expression, improving antioxidant enzyme activities and reduction of hepatic ER stress, which may have been regulated by the Bip-mediated PERK-ATF4-CHOP pathway. In conclusion, our findings confirmed the effectiveness of HIIT and MICT, particularly HIIT, in mitigating hepatic lipid accumulation.
From Cancer Epidemiology to Policy and Practice: the Role of a Comprehensive Cancer Center
Authors: Hiatt Robert A. , Sibley Amanda , Venkatesh Brinda , Cheng Joyce , Dixit Niharika , Fox Rena , Ling Pamela , Nguyen Tung , Oh Debora , Palmer Nynikka R. , Pasick Rena J. , Potter Michael B. , Somsouk Ma , Vargas Roberto Ariel , Vijayaraghavan Maya , Ashworth Alan 
Published: March 2022

Abstract
Purpose of Review
Cancer incidence and mortality are decreasing, but inequities in outcomes persist. This paper describes the San Francisco Cancer Initiative (SF CAN) as a model for the systematic application of epidemiological evidence to reduce the cancer burden and associated inequities.

Recent Findings
SF CAN is a multi-institutional implementation of existing evidence on the prevention and early detection of five common cancers (i.e., breast, prostate, colorectal, liver, and lung/tobacco-related cancers) accounting for 50% of cancer deaths in San Francisco. Five Task Forces follow individual logic models designating inputs, outputs, and outcomes. We describe the progress made and the challenges faced by each Task Force after 5 years of activity.

Summary
SF CAN is a model for how the nation’s Comprehensive Cancer Centers are ideally positioned to leverage cancer epidemiology for evidence-based initiatives that, along with genuine community engagement and multiple stakeholders, can reduce the population burden of cancer.
Momentary Emotion Goals and Spontaneous Emotion Regulation in Daily Life: An Ecological Momentary Assessment Study of Desire for High Versus Low Arousal Positive Emotion
Authors: Swerdlow Benjamin A. , Sandel Devon B. , Pearlstein Jennifer G. , Johnson Sheri L. 
Published: March 2022

AbstractRecent research has highlighted that emotion regulation strategy use varies both between and within people, and specific individual and contextual differences shape strategy use. Further, use of specific emotion regulation strategies relates to a wide array of differential outcomes, including mental health and behavior. Emotion goals (desire for a given emotion state) are thought to play a particularly important role in shaping people’s use of emotion regulation strategies; yet, surprisingly little is known about whether and how momentary emotion goals predict spontaneous strategy use in daily life. In the present investigation, we examined whether ideal desire for high versus low arousal positive affect was associated with subsequent use of specific emotion regulation strategies. Undergraduate participants (final N = 101) completed ecological momentary assessments (final ks = 1,932 for contemporaneous analyses, 1,386 for time-lagged analyses) of their momentary experienced affect, momentary desire for high versus low arousal positive affect, and emotion regulation. Desire for higher arousal predicted greater use of three disengagement strategies: distraction, expressive suppression, and experiential suppression. None of these strategies, though, were associated with sustained enhancement of high arousal (or low arousal) positive affect. These findings point to a possible disconnect between the strategies that people tend to use when they want to feel more arousal and the affective outcomes associated with use of those strategies.
Energy optimised D* AUV path planning with obstacle avoidance and ocean current environment
Authors: Sun Bing , Zhang Wei , Li Shiqi , Zhu Xixi 
Published: March 2022

AbstractFor the path planning of autonomous underwater vehicles (AUVs) in the ocean environment, in addition to the planned path length and safe obstacle avoidance, it is also necessary to pay attention to the impact of ocean currents on the planned path. Therefore, this paper improves the original D* algorithm, and adds the obstacle cost item and the steering angle cost item as constraints on the basis of the original cost function, thus ensuring the navigation safety of the AUV. Considering that ocean currents have a greater impact on the energy consumption of AUVs, this paper establishes a cost model for the impact of ocean currents on AUV energy consumption and applies it to the D* path planning algorithm, so that AUVs can use ocean currents to reduce energy consumption, which can be seen through simulation experiments. The simulation results show that the improvement of the algorithm can plan an optimal energy consumption path.
A method to explore strategies to communicate user experience through storyboards: an automotive design case study
Authors: Rodda Jacob , Ranscombe Charlie , Kuys Blair 
Published: March 2022

Abstract
An engaging user experience is an increasingly important design characteristic in the automotive industry. Compared with physical design characteristics (form, material, mechanical design, appearance), automotive designers find UX (user experience) challenging to communicate during the early stages of the design process without investing in expensive prototypes and/or models. This paper presents the development of a method to explore strategies to communicate UX through the medium of storyboards early in the design process. The method enables links to be drawn between the design tool of storyboarding and the attributes of theoretical UX outlined in theoretical frameworks. By applying this method in a case study of a storyboard created by Ford Design Asia Pacific, we identify how the theoretical attributes of UX are manifested, and we also highlight certain attributes of UX that are difficult to convey during the early phases of automotive design. This research thus contributes a method relevant to practice that assists with effectively communicating UX in early-stage automotive design where higher fidelity prototyping is unviable. Additionally, it enables the study of storyboard outcomes in the design process to assess the degree to which the intended UX is communicated. In doing so, it contributes a first step toward formalizing the analysis of UX in concept design, which in turn opens up this highly subjective area to further research in the automated analysis of conceptual design and even generative design.
On Church’s thesis in cubical assemblies
Authors: Swan Andrew W. , Uemura Taichi 
Published: March 2022

AbstractWe show that Church’s thesis, the axiom stating that all functions on the naturals are computable, does not hold in the cubical assemblies model of cubical type theory. We show that nevertheless Church’s thesis is consistent with univalent type theory by constructing a lex modality in cubical assemblies such that Church’s thesis holds in the corresponding reflective subuniverse.
RETRACTED - THE KRONECKER–WEYL EQUIDISTRIBUTION THEOREM AND GEODESICS IN 3-MANIFOLDS
Authors: BECK J. , CHEN W. W. L. 
Published: March 2022

Abstract
Given any rectangular polyhedron

$3$

-manifold

$\mathcal {P}$

tiled with unit cubes, we find infinitely many explicit directions related to cubic algebraic numbers such that all half-infinite geodesics in these directions are uniformly distributed in

$\mathcal {P}$

.
Response of smooth pigweed (Amaranthus hybridus) accessions from Argentina to herbicides from multiple sites of action
Authors: Scursoni Julio A. , Tuesca Daniel , Balassone Federico , Morello Juan P. , Herrera Daniela Medina , Lescano María C. , Bulacio Nicolás Montero , Crespo Roberto J. , Depetris Mara B. , Vila-Aiub Martin M. 
Published: March 2022

AbstractSmooth pigweed is one of the most troublesome weeds in Argentina. The objective of this study was to evaluate the sensitivity of 50 smooth pigweed accessions to fomesafen, topramezone, glyphosate, 2,4-D, and dicamba. Accessions were collected from soybean fields in various cropping areas in Argentina. The herbicide treatments included 2,4-D (1,140 g ae ha−1), dicamba (560 g ae ha−1), fomesafen (250 g ai ha−1), topramezone (34 g ai ha−1), and glyphosate (1,080 g ae ha−1). Plant survival was evaluated 30 d after each treatment application. Of the smooth pigweed accessions tested, 84% and 76% were susceptible (0% survival) to 2,4-D and dicamba, respectively. More than 90% of the accessions showed high (>60%) survival to glyphosate. While none of the accessions showed total sensitivity (0% survival) to the other herbicides evaluated, 43% and 72% of the accessions showed greater than 60% survival to fomesafen and topramezone, respectively. The differences in survival among accessions confirm the existence of genetic variability in Argentinian smooth pigweed and suggest that weed management practices should be prioritized to preserve the efficacy of these commonly used herbicides.