bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual violence and self-reported sexually transmitted infections among women in sub-Saharan Africa
Authors: Aboagye Richard Gyan , Seidu Abdul-Aziz , Ahinkorah Bright Opoku , Frimpong James Boadu , Yaya Sanni 
Published: February 2022

AbstractSexual violence has proven to be associated with sexually transmitted infections (STIs) in sub-Saharan Africa (SSA). We examined the association between sexual violence and self-reported STIs (SR-STIs) among women in sexual unions in 15 sub-Saharan African countries. This was a cross-sectional study involving the analysis of data from the Demographic and Health Surveys (DHS) from 15 countries in SSA. A total sample of 65,392 women in sexual unions were included in the final analysis. A multilevel binary logistic regression analysis was carried out and the results were presented using adjusted odds ratios (aOR) at 95% Confidence Interval (CI). Women who experienced sexual violence in the last 12 months were more likely to self-report STIs compared to those who did not experience sexual violence [aOR = 1.76, 95% CI = 1.59-1.94]. Compared to women in Angola, those who were in Mali, Nigeria, Sierra Leone, Uganda, and Liberia were more likely to self-report STIs while those in Burundi, Cameroon, Chad, Ethiopia, Malawi, Rwanda, South Africa, Zambia, and Zimbabwe were less likely to self-report STIs. The study has revealed variations in the country level regarding the prevalence of sexual violence and SR-STI in the last 12 months among women in sexual unions in the selected countries. This study has demostrated that sexual violence in the last 12 months is associated with SR-STIs among women in sexual unions. Moreover, factors that predict SR-STIs were observed in this study. Policymakers and agencies that matter could consider the factors identified in this study when designing policies or strengthening existing ones to tackle STIs among women in SSA. To accelerate the progress towards the achievement of Sustainable Development Goal 3, its imperative efforts and interventions must be intensified in SSA to reduce sexual violence which will go a long way to reduce SR-STIs among women.
A meta-analysis of genetic parameter estimates for milk and serum minerals in dairy cows
Authors: Ghavi Hossein-Zadeh Navid 
Published: February 2022

AbstractThis study aimed to conduct a meta-analysis based on a random-effects model to combine different published heritability estimates and genetic correlations for milk and serum minerals in dairy cows. In total, 59 heritability and 25 genetic correlation estimates from 12 articles published between 2009 and 2021 were used. The heritability estimates for milk macro-minerals were moderate to high and ranged from 0.311 (for Na) to 0.420 (for Ca). On the other hand, milk micro-minerals had lower heritabilities with a range from 0.013 (for Fe) to 0.373 (for Zn). The heritability estimates for serum macro-minerals were generally low and varied from 0.126 (for K) to 0.206 (for Mg). The estimates of genetic correlation between milk macro-minerals varied from −0.024 (between Na and K) to 0.625 (between Mg and P). The genetic correlations of milk Ca and P with milk yield were −0.171 and −0.211, respectively. The estimates of genetic parameters reported in this meta-analysis study are appropriate to utilize in breeding plans when valid estimates are not available for milk minerals in dairy cow populations.
Growing Up Indio during the Mexican Miracle: Childhood, Race and the Politics of Memory
Authors: Schaefer Timo 
Published: February 2022

AbstractThis article explores the childhood of a Mexican Indigenous activist, Raúl Javier Gatica Bautista, who was born in 1963 in the Oaxacan market town of Tlaxiaco. Growing up in poor circumstances, Gatica would become a leader in the social movements that between the 1980s and early 2000s pushed Mexico toward gradual democratic reform. The article seeks to describe what it was like to grow up poor and Indigenous at a time (later dubbed the Mexican Miracle) of impressive social and economic advances. Paying special attention to the experience of racial abuse, the article also asks how Gatica's childhood came to inform his political militancy. While other historians have linked the phenomenon of political radicalism in twentieth-century Latin America to particular social conditions, or to the influence and adaptation of global ideologies, this article seeks the origins of Gatica's radicalism in the experience of a racialised childhood.
Building green urban expertise: politicians, agronomists, gardeners and engineers at Lisbon City Council (1840–1900)
Authors: Rodrigues Ana Duarte 
Published: February 2022

AbstractFocusing on Lisbon's green urban renewal under the liberal regime between 1840 and 1900, this article shows how the construction of green urban infrastructure became a part of the liberal agenda for modernizing the capital. The history of Lisbon's nineteenth-century public gardens and parks and tree-lined avenues has received scant attention, but this article reveals the pioneering role played by Lisbon City Council Department of Gardens and Green Grounds and the subsequent creative adaptation of Parisian green urban renewal programmes to Lisbon. These two phases corresponded to the leadership of different professional groups – gardeners and engineers, whose authority derived not only from their expertise but from their role in the making of scientific authority. Finally, this article highlights how the value ascribed to engineering as being more ‘techno-scientific’ than gardening dictated the outcome of the rivalry between gardeners and engineers with the eventual demise of the Department of Gardens and Green Grounds.
Crossed pulmonary arteries and DiGeorge syndrome: case reports and literature review
Authors: Cairello Francesca , Gagliardi Marta , Magrassi Silvia A. , Secco Andrea , Strozzi Maria C. , Felici Enrico 
Published: February 2022

AbstractDiGeorge syndrome has heterogeneous clinical presentation, and for this reason, its diagnosis can be challenging and may be missed. Since CHDs are very common in this patients, they can be considered pillars of clinical diagnosis of the syndrome. Therefore, accurate echocardiography is needed to detect even minor cardiac anomalies, as some specific malformation like crossed pulmonary arteries can be associated with 22q11 syndrome. We report two cases of newborns where the diagnosis of DiGeorge syndrome was suspected after finding crossed pulmonary arteries on echocardiography. In order to reach a timely diagnosis of DiGeorge syndrome, we suggest a careful echocardiographic examination of the pulmonary arteries position in all patients and genetic analysis for 22q11.2 microdeletion in patients in whom malposition has been detected.
Early optimized pharmacological treatment in patients with depression and chronic pain
Authors: Oluboka Oloruntoba J. , Katzman Martin A. , Habert Jeffrey , Khullar Atul , Oakander Margaret A. , McIntosh Diane , McIntyre Roger S. , Soares Claudio N. , Lam Raymond W. , Klassen Larry J. , Tanguay Robert 
Published: February 2022

AbstractMajor depressive disorder (MDD) is the leading cause of disability worldwide. Patients with MDD have high rates of comorbidity with mental and physical conditions, one of which is chronic pain. Chronic pain conditions themselves are also associated with significant disability, and the large number of patients with MDD who have chronic pain drives high levels of disability and compounds healthcare burden. The management of depression in patients who also have chronic pain can be particularly challenging due to underlying mechanisms that are common to both conditions, and because many patients with these conditions are already taking multiple medications. For these reasons, healthcare providers may be reluctant to treat such patients. The Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines provide evidence-based recommendations for the management of MDD and comorbid psychiatric and medical conditions such as anxiety, substance use disorder, and cardiovascular disease; however, comorbid chronic pain is not addressed. In this article, we provide an overview of the pathophysiological and clinical overlap between depression and chronic pain and review evidence-based pharmacological recommendations in current treatment guidelines for MDD and for chronic pain. Based on clinical experience with MDD patients with comorbid pain, we recommend rapidly and aggressively treating depression according to CANMAT treatment guidelines, using antidepressant medications with analgesic properties, while addressing pain with first-line pharmacotherapy as treatment for depression is optimized. We review options for treating pain symptoms that remain after response to antidepressant treatment is achieved.
Solitary Waves Impinging on an Isolated Tropical Reef: Arrival Patterns and Wave Transformation Under Shoaling
Authors: Ramp S. R. , Yang Y.‐J. , Jan S. , Chang M.‐H. , Davis K. A. , Sinnett G. , Bahr F. L. , Reeder D. B. , Ko D. S. , Pawlak G. 
Published: February 2022

AbstractLarge nonlinear internal solitary waves (NLIWs) are known to transit west northwest across the northeastern South China Sea from generation sites around the two‐ridge system in the Luzon Strait. The waves are important because their energy flux and dissipation are several orders of magnitude larger than the surrounding ocean. The wave transit has been well studied up to about the 100 m isobath but observations in shallower water have been scarce. Using oceanographic moorings and an innovative distributed temperature sensing optical cable, the NLIW transformations were observed from 2000 to 2 m on the flanks of Dongsha Atoll (Pratas Reef). Possible outcomes included reflection, refraction around the island, wave breaking, and penetration into shallow water. Upslope penetration depended on incident wave amplitude and direction as well as the local stratification.
Cryo-EM advances in RNA structure determination
Authors: Ma Haiyun , Jia Xinyu , Zhang Kaiming , Su Zhaoming 
Published: February 2022

AbstractCryo-electron microscopy (cryo-EM) has emerged as an unprecedented tool to resolve protein structures at atomic resolution. Structural insights of biological samples not accessible by conventional X-ray crystallography and NMR can be explored with cryo-EM because measurements are carried out under near-native crystal-free conditions, and large protein complexes with conformational and compositional heterogeneity are readily resolved. RNA has remained underexplored in cryo-EM, despite its essential role in various biological processes. This review highlights current challenges and recent progress in using cryo-EM single-particle analysis to determine protein-free RNA structures, enabled by improvement in sample preparation and integration of multiple structural and biochemical methods.
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion
Authors: Tuo Qing-zhang , Liu Yu , Xiang Zheng , Yan Hong-Fa , Zou Ting , Shu Yang , Ding Xu-long , Zou Jin-jun , Xu Shuo , Tang Fei , Gong Yan-qiu , Li Xiao-lan , Guo Yu-jie , Zheng Zhao-yue , Deng Ai-ping , Yang Zhang-zhong , Li Wen-jing , Zhang Shu-ting , Ayton Scott , Bush Ashley I. , Xu Heng , Dai Lunzhi , Dong Biao , Lei Peng 
Published: February 2022

AbstractIschemic stroke represents a significant danger to human beings, especially the elderly. Interventions are only available to remove the clot, and the mechanism of neuronal death during ischemic stroke is still in debate. Ferroptosis is increasingly appreciated as a mechanism of cell death after ischemia in various organs. Here we report that the serine protease, thrombin, instigates ferroptotic signaling by promoting arachidonic acid mobilization and subsequent esterification by the ferroptotic gene, acyl-CoA synthetase long-chain family member 4 (ACSL4). An unbiased multi-omics approach identified thrombin and ACSL4 genes/proteins, and their pro-ferroptotic phosphatidylethanolamine lipid products, as prominently altered upon the middle cerebral artery occlusion in rodents. Genetically or pharmacologically inhibiting multiple points in this pathway attenuated outcomes of models of ischemia in vitro and in vivo. Therefore, the thrombin-ACSL4 axis may be a key therapeutic target to ameliorate ferroptotic neuronal injury during ischemic stroke.
Animal studies for the evaluation of in situ tissue-engineered vascular grafts — a systematic review, evidence map, and meta-analysis
Authors: Koch Suzanne E. , de Kort Bente J. , Holshuijsen Noud , Brouwer Hannah F. M. , van der Valk Dewy C. , Dankers Patricia Y. W. , van Luijk Judith A. K. R. , Hooijmans Carlijn R. , de Vries Rob B. M. , Bouten Carlijn V. C. , Smits Anthal I. P. M. 
Published: February 2022

AbstractVascular in situ tissue engineering (TE) is an approach that uses bioresorbable grafts to induce endogenous regeneration of damaged blood vessels. The evaluation of newly developed in situ TE vascular grafts heavily relies on animal experiments. However, no standard for in vivo models or study design has been defined, hampering inter-study comparisons and translational efficiency. To provide input for formulating such standard, the goal of this study was to map all animal experiments for vascular in situ TE using off-the-shelf available, resorbable synthetic vascular grafts. A literature search (PubMed, Embase) yielded 15,896 studies, of which 182 studies met the inclusion criteria (n = 5,101 animals). The reports displayed a wide variety of study designs, animal models, and biomaterials. Meta-analysis on graft patency with subgroup analysis for species, age, sex, implantation site, and follow-up time demonstrated model-specific variations. This study identifies possibilities for improved design and reporting of animal experiments to increase translational value.
Effects of microRNA-298 on APP and BACE1 translation differ according to cell type and 3′-UTR variation
Authors: Wang Ruizhi , Lahiri Debomoy K. 
Published: February 2022

AbstractAlzheimer’s disease (AD) is marked by neurofibrillary tangles and senile plaques composed of amyloid β (Aβ) peptides. However, specific contributions of different cell types to Aβ deposition remain unknown. Non-coding microRNAs (miRNA) play important roles in AD by regulating translation of major associated proteins, such as Aβ precursor protein (APP) and β-site APP-cleaving enzyme (BACE1), two key proteins associated with Aβ biogenesis. MiRNAs typically silence protein expression via binding specific sites in mRNAs’ 3′-untranslated regions (3′-UTR). MiRNAs regulate protein levels in a cell-type specific manner; however, mechanisms of the variation of miRNA activity remain unknown. We report that miR-298 treatment reduced native APP and BACE1 protein levels in an astrocytic but not in a neuron-like cell line. From miR-298’s effects on APP-3′-UTR activity and native protein levels, we infer that differences in APP 3′-UTR length could explain differential miR-298 activity. Such varied or truncated, but natural, 3′-UTR specific to a given cell type provides an opportunity to regulate native protein levels by particular miRNA. Thus, miRNA’s effect tailoring to a specific cell type, bypassing another undesired cell type with a truncated 3′-UTR would potentially advance clinically-relevant translational research.
New paradigm for configurational entropy in glass-forming systems
Authors: Drozd-Rzoska Aleksandra , Rzoska Sylwester J. , Starzonek Szymon 
Published: February 2022

AbstractWe show that on cooling towards glass transition configurational entropy exhibits more significant changes than predicted by classic relation. A universal formula according to Kauzmann temperature $${T}_{K}$$

T
K

is given: $$S={S}_{0}{t}^{n}$$

S
=

S
0

t

n

, where $$t=\left(T-{T}_{K}\right)/T$$

t
=

T
-

T
K

/
T

. The exponent $$n$$
n
is hypothetically linked to dominated local symmetry. Such a behaviour is coupled to previtreous evolution of heat capacity $$\Delta {C}_{P}^{config.}\left(T\right)=\left(nC/T\right){\left(1-{T}_{K}/T\right)}^{n-1}$$

Δ

C

P

c
o
n
f
i
g
.

T

=

n
C
/
T

1
-

T
K

/
T

n
-
1

associated with finite temperature singularity. These lead to generalised VFT relation, for which the basic equation is retrieved. For many glass-formers, basic VFT equation may have only an effective meaning. A universal-like reliability of the Stickel operator analysis for detecting dynamic crossover phenomenon is also questioned. Notably, distortions-sensitive and derivative-based analysis focused on previtreous changes of configurational entropy and heat capacity for glycerol, ethanol and liquid crystal is applied.
Introducing and applying Newtonian blurring: an augmented dataset of 126,000 human connectomes at braingraph.org
Authors: Keresztes László , Szögi Evelin , Varga Bálint , Grolmusz Vince 
Published: February 2022

AbstractGaussian blurring is a well-established method for image data augmentation: it may generate a large set of images from a small set of pictures for training and testing purposes for Artificial Intelligence (AI) applications. When we apply AI for non-imagelike biological data, hardly any related method exists. Here we introduce the “Newtonian blurring” in human braingraph (or connectome) augmentation: Started from a dataset of 1053 subjects from the public release of the Human Connectome Project, we first repeat a probabilistic weighted braingraph construction algorithm 10 times for describing the connections of distinct cerebral areas, then for every possible set of 7 of these graphs, delete the lower and upper extremes, and average the remaining 7 − 2 = 5 edge-weights for the data of each subject. This way we augment the 1053 graph-set to 120 $$\times $$
×
1053 = 126,360 graphs. In augmentation techniques, it is an important requirement that no artificial additions should be introduced into the dataset. Gaussian blurring and also this Newtonian blurring satisfy this goal. The resulting dataset of 126,360 graphs, each in 5 resolutions (i.e., 631,800 graphs in total), is freely available at the site https://braingraph.org/cms/download-pit-group-connectomes/. Augmenting with Newtonian blurring may also be applicable in other non-image-related fields, where probabilistic processing and data averaging are implemented.
Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation
Authors: Xie Shan-Shan , Deng Yan , Guo Sheng-lan , Li Jia-quan , Zhou Ying-chuan , Liao Juan , Wu Dan-dan , Lan Wei-Fang 
Published: February 2022

AbstractInflammation triggers pulmonary vascular remodelling. Ferroptosis, a nonapoptotic form of cell death that is triggered by iron-dependent lipid peroxidation and contributes to the pathogenesis of several inflammation-related diseases, but its role in pulmonary hypertension (PH) has not been studied. We examined endothelial cell ferroptosis in PH and the potential mechanisms. Pulmonary artery endothelial cells (PAECs) and lung tissues from monocrotaline (MCT)-induced PH rats were analysed for ferroptosis markers, including lipid peroxidation, the labile iron pool (LIP) and the protein expression of glutathione peroxidase 4 (GPX4), ferritin heavy chain 1 (FTH1) and NADPH oxidase-4 (NOX4). The effects of the ferroptosis inhibitor ferrostatin-1 (Fer-1) on endothelial cell ferroptosis and pulmonary vascular remodelling in MCT-induced rats were studied in vitro and in vivo. Ferroptosis was observed in PAECs from MCT-induced PH rats in vitro and in vivo and was characterized by a decline in cell viability accompanied by increases in the LIP and lipid peroxidation, the downregulation of GPX4 and FTH1 expression and the upregulation of NOX4 expression. High-mobility group box 1 (HMGB1)/Toll-like receptor 4 (TLR4)/NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome signalling was measured by western blotting. These changes were significantly blocked by Fer-1 administration in vitro and in vivo. These results suggest that Fer-1 plays a role in inhibiting ferroptosis-mediated PAEC loss during the progression of PH. The ferroptosis-induced inflammatory response depended on the activation of HMGB1/TLR4 signalling, which activated the NLRP3 inflammasome in vivo. We are the first to suggest that pulmonary artery endothelial ferroptosis triggers inflammatory responses via the HMGB1/TLR4/NLRP3 inflammasome signalling pathway in MCT-induced rats. Treating PH with a ferroptosis inhibitor and exploring new treatments based on ferroptosis regulation might be promising therapeutic strategies for PH.
Electric-field induced modulation of amorphous protein aggregates: polarization, deformation, and reorientation
Authors: Kang Kyongok , Platten Florian 
Published: February 2022

AbstractProteins in their native state are only marginally stable and tend to aggregate. However, protein misfolding and condensation are often associated with undesired processes, such as pathogenesis, or unwanted properties, such as reduced biological activity, immunogenicity, or uncontrolled materials properties. Therefore, controlling protein aggregation is very important, but still a major challenge in various fields, including medicine, pharmacology, food processing, and materials science. Here, flexible, amorphous, micron-sized protein aggregates composed of lysozyme molecules reduced by dithiothreitol are used as a model system. The preformed amorphous protein aggregates are exposed to a weak alternating current electric field. Their field response is followed in situ by time-resolved polarized optical microscopy, revealing field-induced deformation, reorientation and enhanced polarization as well as the disintegration of large clusters of aggregates. Small-angle dynamic light scattering was applied to probe the collective microscopic dynamics of amorphous aggregate suspensions. Field-enhanced local oscillations of the intensity auto-correlation function are observed and related to two distinguishable elastic moduli. Our results validate the prospects of electric fields for controlling protein aggregation processes.
The intercapillary space spectrum as a marker of diabetic retinopathy severity on optical coherence tomography angiography
Authors: Terada Noriko , Murakami Tomoaki , Uji Akihito , Ishihara Kenji , Dodo Yoko , Nishikawa Keiichi , Morino Kazuya , Tsujikawa Akitaka 
Published: February 2022

AbstractMicrocirculatory disturbance plays a pivotal role in the pathogenesis in diabetic retinopathy (DR). We retrospectively quantified the total counts and morphological features of intercapillary spaces, i.e., intercapillary areas and nonperfusion areas (NPAs), on swept-source optical coherence tomography angiography (SS-OCTA) images and to evaluate their associations with DR severity grades. We acquired 3 × 3 mm OCTA images in 75 eyes of 62 diabetic patients and 22 eyes of 22 nondiabetic subjects. In the en-face superficial images within the central 2 mm, the areas enclosed by retinal vessels were automatically detected. Their total numbers decreased in some eyes with no apparent retinopathy and most eyes with DR, which allowed us to discriminate diabetic subjects from nondiabetic subjects [area under the receiver operating characteristic curve (AUC) = 0.907]. The areas and area/perimeter ratios continuously increased in DR, indicating a continuum between healthy intercapillary areas and NPAs. The number of intercapillary spaces with a high area/perimeter ratio increased according to DR severity, which showed modest performance in discriminating moderate NPDR or higher grades (AUC = 0.868). These quantified parameters of intercapillary spaces can feasibly be used for the early detection of microcirculatory impairment and the diagnosis of referable DR.