bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studi In Silico Senyawa Hylocereus polyrhizus dan Allium sativum terhadap Enzim HMG-CoA Reduktase
Authors: Normaidah Normaidah , Nurmansyah Dian 
Published: February 2022

Ekstrak buah naga merah (Hylocereus polyrhizus) dan ekstrak bawang putih (Allium sativum) diketahui mampu menurunkan kadar kolesterol total darah dalam studi in vivo. Penambatan molekul dapat dilakukan dalam memprediksi senyawa yang bertanggung jawab berdasarkan nilai docking. Tujuan dari penelitian ini adalah mengetahui zat aktif potensial dari H. polyrhizus dan A. sativum yang berperan penting dalam penurunan kadar kolesterol darah melalui jalur inhibisi enzim HMG-CoA reduktase dalam uji in silico. Reseptor yang digunakan adalah enzim HMG-CoA reduktase (PDB ID: 1HW9) dengan ligan natif simvastatin yang dipreparasi menggunakan YASARA. Struktur senyawa aktif sebanyak 19 senyawa dari buah H. polyrhizus 17 dari A. sativum digambar menggunakan MarvinSketch pada pH 7,4 dengan 10 bentuk konformasi. Proses penambatan molekul dilakukan menggunakan program PLANTS dan divisualisasi dengan Discovery Studio Visualizer. Ligan natif menunjukkan nilai RMSD sebesar 1,5265 Å dengan nilai docking -79,1320. Senyawa 4, dan 17 pada buah H. polyrhizus serta senyawa 36 pada A. sativum menunjukkan kedekatan relative dengan ligan natif lebih dari 95%. Senyawa ini diprediksi mampu menurunkan kadar kolesterol total darah dengan penghambatan enzim HMG-CoA reduktase secara penambatan molekul. Kata Kunci: Buah Naga Merah, Bawang Putih, Vitamin E, Antilipidemia, Kolesterol Total The red dragon fruit extract (Hylocereus polyrhizus) and garlic extract (Allium sativum) are able to decrease the total blood cholesterol levels in in vivo study. The molecular docking can predict the responsible compound based on the docking value. The purpose of this study is to determine the potential active substances of H. polyrhizus and A. sativum which play an important role in reducing blood cholesterol levels through the HMG-CoA reductase enzyme inhibition pathway in the in silico study. The receptor in this study was the enzyme HMG-CoA reductase (PDB ID: 1HW9) with the native ligand simvastatin and prepared using YASARA. The structure of the active compound (19 compounds from H. polyrhizus and 17 compouns from A. sativum) were drawn using MarvinSketch at pH 7.4 with 10 conformations. The molecular docking process was carried out using the PLANTS program and visualized with the Discovery Studio Visualizer. The native ligand showed RMSD value of 1.5265 Å with a docking value of -79.1320. The compounds 4 and 17 in H. polyrhizus fruit and compounds 36 in A. sativum showed relative closeness with native ligands of more than 95% of the docking score. Based on molecular docking, these compounds are to be able to decrease the total blood cholesterol levels by inhibiting the HMG-CoA reductase enzyme.
Review: Aktivitas Antihiperurisemia Beberapa Tanaman dari Arboretum Garut
Authors: Yanti Puja , Subarnas Anas , Renggana Hesti 
Published: February 2022

Hiperurisemia merupakan suatu kondisi berlebihnya kadar asam urat dalam darah. Hal ini dapat terjadi karena adanya kelebihan produksi asam urat dan kekurangan ekskresi asam urat, yaitu ditandai dengan kadar asam urat yang tinggi (> 7 mg/ dL). Jika hal tersebut terjadi secara terus-menerus maka akan terjadi gout arthritis. Di Arboretum Garut Terdapat banyak tanaman yang dapat digunakan sebagai antihiperurisemia seperti sirsak (Annona muricata L.), kayu manis (Cinnamomum burmanii), temu putih (Curcuma zedoaria), jamblang (Syzigium cumini), kersen (Muntingia calabura L.), pucuk merah (Syzigium myrrtifolium), dan salam (Syzigium polyanthum). Review jurnal ini membahas aktivitas antihiperurisemia beberapa tanaman yang berada di Arboretum Garut. Metode yang digunakan yaitu studi literatur beberapa jurnal yang didapat melalui situs google scholar, sciencedirect, Elsevier, dan sebagainya. Hasil yang didapat dari beberapa tanaman tersebut memiliki aktivitas antihiperurisemia dan tanaman yang memiliki persentase penurunan asam urat terbesar yaitu daun S. polyanthum dengan nilai persentase penurunan asam urat sebanyak 79,35%. Daun S. polyanthum memiliki potensi antihiperurisemia paling baik, sehingga perlu dikembangkan lebih banyak di Arboretum Garut. Kata Kunci: Arboretum, Asam Urat, Gout, Hiperurisemia, Tanaman Obat Hyperuricemia is a condition of excessive levels of uric acid in the blood. This can occur due to an overproduction of uric acid and a lack of uric acid excretion, which is characterized by high uric acid levels (> 7 mg / dL). If it happens continuously, gout arthritis will occur. In Garut Arboretum, there are many plants that can be used as antihyperuricemia such as soursop (Annona muricata L.), cinnamon (Cinnamomum burmanii), white turmeric (Curcuma zedoaria), java plum (Syzigium cumini), cotton candy berry (Muntingia calabura L.), pucuk merah (Syzigium myrrtifolium), and indian baywatch (Syzigium polyanthum). This journal review discusses the antihyperuricemia activity of several plants in Garut Arboretum. The method used is a literature study of several journals obtained from the google scholar site, sciencedirect, Elsevier, etc. The results show that several plants have antihyperuricemia activity and among those plants the S. polyanthum) have the highest reducing effect on blood uric acid with the reducing percentage of 79.35%. The leaves of S. polyanthum plant have the best potential for antihyperuricemia, so this plant is suggested to be developed in the Garut Arboretum.
The Effect of Person-Job Fit on Turnover Intention: Mediated by Job Satisfaction
Authors: Nugraha Yugi Adhari 
Published: February 2022

Abstract
Background: In the banking industry, employees have an important role in the success and stability of the company in facing challenges, competition, and employee mobility..
Objective: aims to analyze the effect of person-job fit and job satisfaction on employee turnover intention.
Authenticity/Value: The novelty of this research is because there are still few who pay attention to the problem of the influence of persob-job fit on turnover intention for the sustainability of the bank.
Limitations: The research problem is limited to the effect of person-job fit and job satisfaction on employee turnover intention.
Methodology/ Approach: This research was conducted with a sample unit taken from 54 employees. Research data obtained by distributing questionnaires were analyzed using the SEM-PLS method.
Findings: The results showed that there was an effect of person-job fit on job satisfaction. There is an effect of job satisfaction on turnover intention. There is no effect of person-job fit on employee turnover intention.
Analysis of Outsourcing System and Work Motivation on Employee Performance
Authors: Setiawati Neng Eti 
Published: February 2022

Background - Currently, many companies are implementing outsourcing systems for their company's HR management. Outsourcing is a company that uses human resources from other parties (external) to carry out work activities that are usually handled by internal staff and resources. The problem that exists is because the outsourcing system affects the performance of employees at a food ingredients factory in Cilegon, where there are still high complaints from clients regarding the decline in the performance of forklift operator employees placed in their company. This shows the inaccuracy at work leads to a lack of employee motivation. Employee motivation problems can be the cause of low employee performance in a company.
Purpose - The objectives of this study are (1) to determine the effect of the outsourcing system on employee performance and (2) to see the effect of work motivation on employee performance.
Originality/Value - This study tested 2 hypotheses with data sources originating from respondents of outsourcing employees of PT. AMP, a division of forklift operators at the Cilegon grocery factory, analyzed the influence of the outsourcing system and work motivation on employee performance in the company.
Research Limitations - information, primary and secondary data in this study were only obtained from PT. AMP
Design/methodology/approach - The population and sample of this study were all outsourced employees of PT. The AMP division of forklift operators placed 30 people in a food ingredients factory in Cilegon. This study uses a quantitative approach method. The data collection technique used primary data in the form of a questionnaire. The data analysis technique of this research used the Structural Equation Modeling-Partial Least Square (SEM-PLS) method.
Findings - Based on the results of the direct influence hypothesis research, it is known that the outsourcing system has a positive and significant effect on employee performance. And motivation has no significant effect on employee performance
The Influence of Servant Leadership and Employee Compensation on Employee Engagement Through Employee Job Satisfaction as an Intervening Variable at PT Indonesia Power Suralaya Power Generation Unit
Authors: Christianto Reinardus Dwi Prio 
Published: February 2022

Background - Nowadays, employee engagement is a major concern for organizational leaders around the world. Human Resources (HR) is a key element of a company that will support effective and efficient organizational governance (Christian et al., 2021). However, not all employees have the same level of engagement, factors that can affect employee commitment such as motivation, job satisfaction, leadership, diversity of co-workers, organizational culture, and others (Vinsensius et al., 2019).
Purpose - This study aims to analyze: (1) the magnitude of the influence of servant leadership on employee engagement, (2) the magnitude of the influence of employee compensation on employee engagement, (3) the magnitude of the influence of servant leadership on employee job satisfaction, (4) the magnitude of the effect of employee compensation on employee engagement. employee job satisfaction, and (5) the magnitude of the influence of employee job satisfaction on employee engagement at PT Indonesia Power Suralaya Power Generation Unit.
Originality/value - The novelty (originality or value) of this research is that servant leadership has no effect on employee engagement and employee compensation has no effect on employee job satisfaction.
Research Limitations - The limitations of this study are only to get an idea of ​​the perceptions of employees of PT Indonesia Power Suralaya Power Generation Unit regarding servant leadership, employee compensation, employee job satisfaction and employee engagement.
Design/methodology/approach - The population in this study are employees of PT Indonesia Power Suralaya Power Generation Unit which is located at Jalan Raya PLTU Suralaya, Cilegon, Banten. The research method is quantitative using a questionnaire with a Likert scale and the sampling technique is done by simple random sampling. The number of samples used as many as 32 samples to test the hypothesis. Structural Equation Modeling was used to test the statistical significance of the path coefficients, and processed using the PLS Smart 3.2.9 program.
Findings - The results showed that servant leadership and employee compensation affected job satisfaction by 64.9%, while employee engagement was influenced by 86.8%. This direct effect shows that servant leadership has no effect on employee engagement, employee compensation has a positive and significant effect on employee engagement, servant leadership has a positive and significant effect on employee job satisfaction, employee compensation has no effect on employee job satisfaction, and employee job satisfaction has a positive effect. and significant to employee engagement.
Arthroscopic Medial Patellofemoral Ligament Insertion Reconstruction and Plication for Medial Patellar Retinaculum Using Suture Anchor in First Acute Patellar Dislocation
Authors: Xu Tao , Xu Liu-hai , Li Xin-zhi , Zhou You 
Published: February 2022

Abstract
BackgroundThe objective of this study was to evaluate the clinical results of arthroscopic medial patellofemoral ligament (MPFL) insertion reconstruction and plication for medial patellar retinaculum using suture anchor combined with lateral retinacular release in first acute patellar dislocation (APD) with MPFL insertion injury in adolescents.MethodsA prospective study was performed between January 2016 and July 2019. The series included 61 cases of adolescent patients with first APD. There were 7 males and 54 females with an average age of 15.5 years (10 to 22). All cases were treated with arthroscopic suture anchor plication for medial patellar retinaculum combined with lateral retinacular release. Congruence angle (CA), lateral patellar angle (LPA), and patellar tilt angle (PTA) are measured by CT scan between last follow-up and preoperative. In addition, the patients were evaluated with the Lysholm and Kujala scores.ResultsThe average follow-up time was 40.9 months (24-60 months). All 61 knees showed excellent or good results postoperatively. The Lysholm score increased significantly from 58.6±8.1 to 91.9±5.0 at the last follow-up postoperatively (P<0.001 ). The Kujala scores increased significantly from 60.4±7.3 to 88.9±4.8 at the last follow-up postoperatively (P < 0.001). CA in 0° extension position was improved significantly from 19.8±2.1° preoperatively to -6.7±1.7° at the last follow-up (P<0.001), LPA was increased from -7.4±2.2° to 5.7±1.8° (P<0.001), and PTA was increased from 23.8±2.9° to 12.3 ±2.3° (P<0.001). The postoperative mean Lysholm and Kujala scores were 91.9 (81–100) and 88.9 (79–100), respectively.ConclusionsWhen the first APD occurs associated with the MPFL avulsed from the patella, the presented technique could not only reattach MPFL at the patellar border but also strengthen the medial patellar retinaculum. This anatomical repair technique can significantly improve the stability of the patella and has the advantage of being less invasive by the full-arthroscopic approach.Trial registration: retrospectively registered
The Optimal Induction Timing In Prelabor Rupture of Membranes: A Retrospective Study
Authors: Gal Bachar , Doron Shemesh , Naama Farago , Yoav Siegler , Roy Lauterbach , Nizar Khatib , Yuval Ginsberg , Ron Beloosesky , Zeev Weiner , Dana Vitner 
Published: February 2022

Abstract
Objective: Term prelabor rupture of membrane (PROM) occurs in 8% of term deliveries, but it is unclear when to initiate induction. Our objective was to assess the optimal timing of oxytocin induction in management of term PROM in terms of maternal and neonatal outcomes.Methods: A retrospective cohort at a single tertiary care center from 2010 to 2020. All singleton pregnancies with PROM beyond 37 weeks gestation, without regular uterine contractions, were included. Eligible women were divided into three groups according to the timing of oxytocin induction (<12; 12-24; >24 hours) following PROM. Results: Of 9,443 women presented with term PROM, of them 1676 were included. They were classified according timing of oxytocin induction initiation following PROM: 1,127 within 12 hours; 285 within 12-24 hours; 264 after 24 hours. There were no significant differences in baseline demographic characteristics between groups. Women who were early induced delivered significantly sooner than those who received oxytocin later (45 vs. 28.2 vs. 23.2 hours, respectively, p<0.001. Maternal infection rate was similar and unrelated to oxytocin starting time. Their babies were less likely to receive antibiotics (26.8% vs. 38.6% vs. 33.33%, respectively; p<0.001), and they had lower rates of composite adverse neonatal outcome (RR=1.27, p=0.0307). Conclusion: In term PROM, early induction (within 12 hours of PROM) may be recommended to reduce time-do-delivery interval and increase delivery rate within 24 hours. It may be of economic significance and improve women satisfaction. Furthermore, early induction may also improve neonatal outcomes, without worsening maternal outcomes.
Inpatient Generalist Palliative Care During the SARS-CoV-2 Pandemic – Experiences, Challenges and Potential Solutions
Authors: Schallenburger Manuela , Reuters Marie Christine , Schwartz Jacqueline , Fischer Marius , Roch Carmen , Werner Liane , Bausewein Claudia , Simon Steffen T , Oorschot Birgitt , Neukirchen Martin 
Published: February 2022

Abstract
Background: The SARS-CoV-2 pandemic has presented major challenges to the health system. Despite high acute case numbers, non-Covid-19 patients still need to be cared for. Due to the severity of the disease and a possible stressful overall situation, palliative patients also require comprehensive care during pandemic times. In addition to specialised palliative care facilities, this also takes place in general patient care. In order to ensure this general palliative care also in pandemic times, the experience of the staff should be used. The aim of this paper is to examine challenges and possible solutions of inpatient general palliative care in relation to the care of seriously ill and dying patients and their relatives. Methods: Qualitative semi-structured focus groups were conducted online for the study. Participants were staff from intensive care or isolation wards or from units where vulnerable patients (e.g. with cognitive impairment) are cared for. The focus groups were recorded and subsequently transcribed. The data material was analysed with the content structuring content analysis according to Kuckartz.Results: Five focus groups with four to eight health care professionals with various backgrounds were conducted. Fifteen main categories with two to eight subcategories were identified. Based on frequency and the importance expressed by the focus groups, six categories were extracted as central aspects: visiting regulations, communication with relatives, hygiene measures, cooperation, determination of the patients will and the possibility to say farewell.Conclusion: The pandemic situation produced several challenges needing specific solutions in order to manage the care of seriously ill and dying patients. Especially visiting needs regulation to prevent social isolation and dying alone. Finding alternative communication ways as well as interprofessional and interdisciplinary cooperation is a precondition for individualised care of seriously ill and dying patients and their relatives. Measures preventing infections should be transparently communicated in hospitals.
Seeking a Tool to Assess Consumer Involvement in the Pharmaceutical Area: the Case of Consumer Involvement Profile as a Popular Scale
Authors: Momeni Fatemeh , Rangchian Maryam , Ataei Sara , Moradi Mohsen 
Published: February 2022

Abstract
Background Involvement is one of the most important determinants of consumers' behaviour. Considering the special position of the pharmaceutical products in public health and peace of mind, awareness from consumer involvement toward these products is very helpful for health system policy makers. To this end, access to a valid reliable tool to evaluate this concept is of great importance. Therefore, the present study aimed to evaluate the psychometric properties of the Persian version of a popular related questionnaire, naming Consumer Involvement Profile (CIP), to be used to assess consumers' involvement regarding pharmaceutical products.Methods This cross-sectional study was conducted from January 2020 to March 2021 in Hamadan, Iran. Data were gathered using the 16-item CIP questionnaire with sentences adapted for the pharmaceutical products. Content validity, internal consistency, overtime reliability based on the test-retest method, construct validity (including convergent and discriminant validity), and goodness of fit were evaluated for the questionnaire. Results Data obtained from 357 respondents underwent analysis. Overtime reliability was confirmed by a coefficient equal to 0.836 (p-value= 0.000). Cronbach’s alpha was only lower than 0.6 for the "risk probability" dimension. Regarding the convergent validity, two items had loading factors less than 0.5, which were omitted from the modified model. All CR values were higher than the corresponding AVE values. However, for two dimensions CR was less than 0.7. Although, based on the MSV, ASV and Fornell-Larcker test, importance, risk probability and risk importance, as well as importance with pleasure showed some overlaps, the discriminant validity was confirmed by HTMT. Goodness of fit indices were completely satisfying for the both primary and modified models. Conclusion The CIP questionnaire showed an acceptable performance to measure the consumers' involvement in pharmaceutical products. This is the first study to introduce a valid tool based on a well-known scale for measuring consumer involvement in the field of medicines. Such instruments facilitate to manufacturers and policymakers in this field to make informed decisions and promote community health.
A Molecular Ratchet Model without Feedback Control
Authors: Jiang Jiantang 
Published: February 2022

Abstract
Feedback controllers (which act like Maxwell's demon) can extract useful work by rectifying thermal fluctuations. However, feedback controllers consume energy, and the work extracted cannot compensate the energy consumed. In this paper, we propose a molecular ratchet model without any feedback controllers and report the simulation results to support its feasibility. In our model, we break the dynamic symmetry by using an electric field to create a concentration difference of solute ions between the two liquid surfaces of a solution. The simulation results show that our ratchet model can induce a continuous net solvent flux. In that sense, all the positive work extracted from the heat bath can be available energy because it doesn't need to compensate the energy cost of the feedback controller. Our work makes it possible to construct an entirely mechanical molecule-rectifying system as Szilárd expected.
Stability and performance of monetary and fiscal policies in the euro euro area
Authors: Daly Hounaida 
Published: February 2022

Abstract
Following the importance of coordination of monetary and fiscal policies, the investigation of the causal relationship between public debt and budget deficit has a fundamental role in implementing suitable policies. This paper examines the fiscal policy sustainability and the impact of monetary policy on public debt management in Euro Area from 1980 to 2014. The analysis is based on error-correction models and cointegrated VAR modelling. The evidence does not let hear strong political coordination in Euro Area, and supports the idea that the monetary policy is more stabilizing in its influence on the economic activity than the budget policy. An important policy implication resulting from this study is that the fiscal rule generates a divergent dynamic of the public debt. Our results in this paper suggest the Keynesian effects of macroeconomic policies in the eurozone and concludes that there is a sort of complementarity between monetary and fiscal policies in some euro area countries insofar as a restrictive monetary policy (higher interest rates, interest) seems always accompanied by a restrictive fiscal policy (higher taxes or lower public spending) and vice versa. Thus, we consider that the debt has a positive effect on the budget deficit, which translates into behavior that destabilizes the debt. Moreover, fiscal policy is not sustainable in Belgium, Italy, Ireland and Greece. Furthermore, Fiscal policy is sustainable in France and Spain.