bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erythropoietin – a potential tool in the treatment of depressive disorders?
Authors: Simões G. , Jesus S. , Silva R. 
Published: September 2022

IntroductionDepression is one of the leading causes of psychiatric disability across the globe because of its high prevalence and chronic, treatment resistant and recurrent nature. Erythropoietin (EPO), well known for its effects on blood cells, has also a key role in neuroprotection and cognitive function.ObjectivesThe authors aim to explore the potential of EPO to treat depressive disorders (DD) and related cognitive dysfunction.MethodsA literature research was conducted on PubMed starting from the MeSH terms: “Erythropoietin” and “Depressive Disorders”. The results selected for our analysis corresponded to investigations using EPO based on an adult population with DD.Results

The research provided 14 results, of which 9 met the defined criteria. Different types of studies with variable samples were considered, including randomized clinical trials (RCTs) and a systematic review. Overall, despite records of reduction in depression symptomatology and increased quality of life, evidence does not demonstrate statistically significant reductions in depression severity through the use of EPO in the treatment of DD. However, several RCTs examined its effect on cognitive performance, founding effective improvements in memory, verbal recall and recognition. The underlying potential mechanisms and the current limitations in the use of EPO, and of the available studies are analysed and discussed.ConclusionsAlthough EPO does not appear to be effective treating depression, it may play a role in improvement of deficits in memory and executive function. Larger RCTs evaluating its potential use are needed, in order to move towards better clinical practice, quality of life and functional reintegration of these patients.DisclosureNo significant relationships.
“Could she be a good mother?. The stigma of mental illness in motherhood. A case report
Authors: López Rodrigo M.V. , Osca Oliver A. , Palomo Monge M. , Pérez Fominaya M. 
Published: September 2022

Introduction
Approximately 15% of pregnant women suffer from a mental illness, however only half of them accept psychopharmacological treatment. One of the reasons for refusing treatment is the stigma attached to it.An important part of functional recovery is defining identity. This identity is multifactorial and is defined by several variables, one of them being gender.Several studies on motherhood in women with mental illness define the importance of a mothering identity, providing meaning and values. We present the case of a 39-year-old woman, mother of a two-year-old child, undergoing follow-up at a psychiatric clinic for recurrent depressive episodes and a history of two suicide attempts ten years ago. Currently stable in treatment with escitalopram 10 mg and lorazepam 1 mg if necessary.The woman refers the desire to abandon treatment after realizing that she is pregnant again. Therapeutic accompaniment is decided. The social worker from the obstetric service communicates with the psychiatric service to question the woman’s ability to care for a child with her psychiatric history.ObjectivesDetermine the stigma of mental illness, including among healthcare workers.MethodsThe woman makes her decision with full judgment. The patient is accompanied during pregnancy without incident, with clinical stability.ResultsAfter delivery, the patient decides to resume psychopharmacological treatment.Conclusions
Having a mental illness does not determine a woman’s ability to be a mother. As long as it is agreed with the psychiatrist, patients have the right to make decisions about their treatment.DisclosureNo significant relationships.
Ketamine and Electroconvulsive Therapy: Better Together?
Authors: Fraga A. , Mesquita B. , Facucho-Oliveira J. , Espada-Santos P. , Albuquerque M. , Neves R. , Moutinho A. 
Published: September 2022

IntroductionMajor depressive disorder (MDD) is a highly prevalent clinical condition with a leading cause of disability worldwide. The currently available therapeutic agents have important limitations regarding side effects, partial or non-responsiveness. Patients are considered to have treatment-resistant depression (TRD) if there is no effect or minimal effectiveness after receiving adequate dose-duration use of antidepressants from two different categories. For this patients, electroconvulsive therapy (ECT) can be a treatment option and new therapies appear to tackle TRD like ketamine, a dissociative anesthetic and analgesic.ObjectivesThe authors elaborate a narrative literature review to understand if ketamine might enhance the antidepressant efficacy of ECT.MethodsPubMed database searched using the terms “Electroconvulsive therapy”, “ketamine” and “treatment-resistant depression”.ResultsECT is currently recommended as an end-line therapy for TRD. Memory impairment after ECT could be a consequence of indiscriminate activation or saturation of glutamate receptors during the treatment, disrupting hippocampal plasticity involved in memory. Ketamine inhibits N-methyl-d-aspartate (NMDA) receptors, while stimulating glutamate release and was proposed as an ECT adjuvant, might reduce cognitive adverse effects, time until response/ remission and inclusively improve response rates to ECT.

However, response and remission rates of ketamine in ECT showed no significant difference from the comparator groups and was associated with higher rates of psychiatric and cardiovascular adverse events.ConclusionsThe results did not support the use the combination of ketamine and propofol as anesthetic agents for ECT in patients with MDD. However, further studies are needed to investigate the beneficial clinical and cognitive effects of ketamine alone in ECT settings.DisclosureNo significant relationships.
Depression and anxiety among psychiatry residents
Authors: Bouattour N. , Bouattour W. , Abdelkefi M. , Messedi N. , Charfeddine F. , Aribi L. , Aloulou J. 
Published: September 2022

IntroductionResidency training has been reported as being stressful which may lead to different mental disorders.ObjectivesTo study the prevalence and associated factors of anxiety and depression symptoms among psychiatry residents.MethodsA cross-sectional study was conducted through an online survey among psychiatry residents. Participants completed an anonymous self-administered questionnaire and the HADS questionnaire for screening anxiety and depression.ResultsForty responses were collected.The average age of the sample was 28.08 ± 2.43 and the sex-ratio (F/M) was 0.875. Eleven participants were married. Eight residents were smokers. The prevalence of alcohol use and cannabis use was 22.5 % and 5% respectively. Half of participants were first year residents and near three-quarter of them (72.5%) declared working in poor conditions. A considerable proportion of participants had symptoms of anxiety and depression. The prevalence of anxiety case and depression case was 52.5% and 47.5% respectively. The prevalence of Anxiety symptoms and depression symptoms was significantly higher in female participants (p = 0.017, p=0.034 respectively). Poor conditions of the workplace were significantly associated with depression symptoms (p=0.004).ConclusionsTraining residents in psychiatry showed high rates of anxiety and depression symptoms. Screening and early management of these psychiatric manifestations is necessary. In addition, improving working conditions would upgrade their training and quality of life.DisclosureNo significant relationships.
Can Prescribed Cannabinoids Substitute Cannabis?
Authors: Batalla A. 
Published: September 2022

Legislative changes in the last years have made possible the prescription of medical cannabis in several countries, often following a growing public demand. However, the medical indications for use and the access to prescribed cannabis are still limited. Prescribers face several challenges in the form of barriers and dilemmas, often related to stigma, and deficient information and training. As a result, many people keep on using illicit cannabis for medical problems. In this session we will outline the most common controversies of cannabis prescription, particularly in psychiatry. We will discuss the ethical considerations regarding prescription practices, the benefit-risk assessment, the limitations of the current knowledge, and some potential solutions to respond to the strong demand from patients and families.DisclosureNo significant relationships.
Postpartum Depression, Catatonia and Covid-19 Infection: One Case, Different Clinical Presentations
Authors: Leite D. , Antunes A.F. 
Published: September 2022

IntroductionPost-partum depression may occur in the first year after childbirth in approximately 25% of women, at times presenting with psychotic symptoms and catatonic states. Catatonia is a psychomotor syndrome that occurs in association with various neuropsychiatric disorders and can be described according to the characteristics of its manifestation in types such as retarded or agitated.ObjectivesWe report the case of a patient with postpartum depression and catatonic syndrome who, after a session of electroconvulsive therapy, was infected with Sars-COV-2, suspended treatment, and had her condition aggravated with distinct clinical manifestations.MethodsClinical case report and non-systematic review of articles consulted in the PubMed platform.ResultsA 24-year-old patient develops depressive symptoms and obsessive behaviour 6 months after delivery and deteriorates with mutism, stupor and motor immobility. She was hospitalised and medicated with lorazepam, with no improvement. One session of electroconvulsive therapy was carried out with improvement of the symptoms. Due to an inpatient Covid-19 outbreak, in which the patient was infected, treatment was suspended. During isolation, deterioration of the patient’s condition was observed with psychomotor agitation, bizarre behaviour, and perseverative speech. The patient resumed treatment with ECT, with total remission of the catatonic syndrome and improvement of the affective symptoms.ConclusionsCatatonic syndromes are relatively rare, but its association with post-partum depression is not so uncommon. The occurrence of different presentations of catatonia, although described as possible in the same episode in the literature, were not found in any clinical studies reviewed, which leads us to conclude that it is an uncommon situation.DisclosureNo significant relationships.
Integration of real-world clinical data into the Munich Mental Health Biobank – clinical and scientific potential and challenges
Authors: Kálmán J. , Burkhardt G. , Pogarell O. , Padberg F. , Schulze T. , Falkai P. 
Published: September 2022

Introduction
New insights into the pathophysiology of mental disorders and innovations in psychiatric care depend on the availability of representative, longitudinal and multidimensional datasets across diverse, transdiagnostic populations. Biobanks usually attempt to collect such data in parallel to clinical routine, which is resource-intensive, puts additional burden on health-care providers, and may reduce the generalizability of the results. Despite containing rich phenotypic and biological information, data generated in routine clinical care is seldomly used for research purposes, because it is usually unstructured and locked in data silos. To truly link clinical practice and research, solutions that optimize the generation and scientific utilization of real-world clinical data are needed.ObjectivesEvaluation of a new digital infrastructure which warrants the efficient, automatized, and structured collection of real-world data in psychiatric care, and integrates the generated data into existing biobanking efforts.MethodsWe have developed a new documentation system which augments the existing IT-structures, enables the collection of routine clinical data in a structured format and involves patients in the data generation process. In an implementation science approach, to replicate and extend the findings of Blitz et al. (JMIR Ment Health 2021), we are investigating the acceptance, efficacy, and safety of the system in our outpatient clinic for affective disorders.ResultsFirst results describing the technical safety, usage metrics, and acceptance of the system, and the quality of the collected data will be presented.ConclusionsChallenges of collecting real-world data for biobanking and research purposes and perspectives on future digital solutions will be discussed.DisclosureNo significant relationships.
Creating a Digital Psychoeducation Programme for bipolar disorder in the COVID-19 pandemic
Authors: Gadelrab R. , Simblett S. , Hook J. , Rickwood S. , Martinez J. , Johnstone M. , Flower C. , Bourne S. , Young A. , Macritchie K. 
Published: September 2022

IntroductionThe Covid-19 pandemic profoundly affected delivery and accessibility of mental health care services at a time when most needed. The OPTIMA Mood Disorder Service, a specialist bipolar disorder service, adapted group psychoeducation programme for delivery on-line.ObjectivesWe report the feasibility of creating a digital psychoeducation programme.MethodsThe OPTIMA ten session group psychoeducation programme was converted into a ‘Digital’ intervention using video-conferencing. Sessions offered a range of key topics, derived from the initial Barcelona Group Psychoeducation Programme. At the time of writing, OPTIMA had fully completed two 10 session digital courses.ResultsA total of 12 people (6 in each group) consented to be part of a service evaluation of the digital groups. Just over half of the participants were women (7/12; 58.3%) and one identified as being non-binary (8.3); remaining participants were men. Age of participants ranged from 25 years to 65 years (Mean=42.3; SD=13.1). Data showed a high level of engagement (77%) All participants reported some improvement with a mean Bipolar Self-Efficacy scale (BPSES) post-group score of 105.6 (SD=14.8). At group level, this change was not statistically significant (F (1, 15) = 0.71, p=0.41). At an individual level, two out of five showed a reliable change index >1.96.Conclusions
Delivering a ‘digital’ group psychoeducation programme was possible due to careful planning and programme development. There was good uptake from service users suggesting it is a feasible approach with preliminary evidence of clinical benefit.DisclosureNo significant relationships.
Opioid Substitution: More than Only Methadone!
Authors: Torrens M. 
Published: September 2022

Opioid misuse and its rising rates of morbidity and associated mortality is an increasing area of concern worldwide. The licit/illicit consumption of opioids ranging from plant-based substances and pharmaceutical drugs (particularly analgesia) to the new synthetic opioids, has brought opioid use disorder (OUD) back to the public health concerns, including not only prevention but also availability of evidence-based treatments. Agonist opioids have demonstrated by long high efficacy and effectiveness for OUD treatment. Although methadone has been the more prescribed drug in most of the countries where opioid agonist treatment is available, other agonist opioids can be prescribed. We will present a start of the art of other agonist opioids available for the treatment of OUD, emphasizing in the differences among them, in line with of personalizing treatment in addiction. We will focus on morphine slow release, buprenorphine (with or without naloxone, sublingual or long-lasting) and diacetylmorphine.DisclosureMT has been consultant/advisor and/or speaker for Gilead Sciences, Merck Sharp & Dohme Corp, Servier, Adamed, Lundbeck, Camurus, Rovi and Molteni.
Compare in-person and online outpatient visits based on changes in patients’ treatment
Authors: Szczygieł K. , Podwalski P. 
Published: September 2022

IntroductionThe COVID epidemic has forced psychiatrists to introduce changes in outpatient clinics. A significant proportion of visits began without the patient’s face-to-face contact with the doctor. Are these visits stigmatized with a worse assessment of mental state? We know that much of the information flow takes place outside of verbal contact. In telephone contact, psychiatrists are limited to listening to the patient’s response and we know that non-verbal speech does not always go hand in hand with words.ObjectivesThe aim of the study is to compare face-to-face visits with a psychiatrist with outpatient visits by telephone in terms of changes in the treatment applied by psychiatrists.MethodsThe frequency of introducing changes in the current pharmacological treatment of patients was compared. Face-to-face visits to the outpatient clinic and visits where psychiatrists contacted patients via telephone were analyzed. Treatment change was defined as a reduction or increase in drug dose, drug discontinuation or the initiation of a new drug by a psychiatrist.ResultsWe assumed that visits without non-verbal contact do not provide as much information as direct visits. Consequently, patients who are often negative about the need to take medications over the phone will present themselves better to psychiatrists, thus the change in treatment will be used less frequently in this group. The results will be presented at the conference.ConclusionsCurrently, various forms of psychiatric care are evolving to adapt to new needs. We should also be aware of the consequences of these changes.DisclosureNo significant relationships.
Digital universal parent training program to promote positive parenting skills – A randomized waiting-list study
Authors: Mishina K. , Kinnunen M. , Heikkinen A. , Saarinen S. , Hinkka-Yli-Salomäki S. , Sinokki A. , Imberg T. , Sourander A. 
Published: September 2022

IntroductionParent training programs have high potential to promote positive parent-child relationships as well as reach and engage parents to participate. Digitally delivered programs may overcome the barriers associated with face-to-face interventions, such as stigma, logistic challenges and limited resources.ObjectivesTo assess the effectiveness and feasibility of digital universal parent training program for families with 3 years-old children, focusing on parenting skills and child´s behavior.MethodsA non-blinded randomized controlled trial (RCT) with two groups: (I) the intervention group, in which participants receive the parent training and (II) the waiting list group, in which participants are placed on a waiting list to receive the parent training intervention after the first follow-up measurement have been completed. Participants must meet the following inclusion criteria: a) guardians having a child age 3 years, b) participating to annual health checkup in child health clinic, c) at least one of the guardian is able to understand the languages that intervention is provided.ResultsPilot study with feasibility assessment finished at early 2021. Recruitment of the wider RCT study is currently ongoing. The results from the pilot study and more detailed description about the intervention will be presented.ConclusionsThis study with good national geographical coverage is a unique possibility to evaluate universal parenting program on promoting parenting behaviors associated with the promotion of optimal child emotional development. This study also provides population level information about parenting skills and child´s behavior.DisclosureNo significant relationships.
New way of Providing Care: the Role of Telemental Health
Authors: Volpe U. 
Published: September 2022

Telemental health care can be defined as the delivery of mental health care services at distance, by using information and communication technologies for the exchange of valid information for diagnosis, treatment and prevention of mental illnesses, as well as for research and education in the field of clinical psychiatry. While telemental health care practice was long established in many countries, its development proceeded with some variability worldwide. Over the past months, however, the recent COVID-19 pandemic has abruptly spread telemental health care practice worldwide, mostly to ensure the provision of care and assistance to psychiatric patients in spite of the governmental social contact restrictions. Although the process of rapid implementation has often happened at different rates and with different quality standards, across the various countries and sites, a global increase of the use of digital technologies has been reported. On the other hand, such recent events have also sparked a real paradigm shift in mental health care, significantly expanding the scope of e-mental health, given the recent availability of newer tools of digital psychiatry. In more detail, the use of mobile phones applications, of social media, of immersive reality and of chatbots is now driving psychiatry towards envisioning a more hybrid form of psychiatric practice, which holds the potential to finally overcome the traditional gap between the unmet needs of psychiatric patients and the relative lack of services and resources in mental health care. Here, the research evidence and the most compelling implementation issues in digital psychiatry will be reviewed.DisclosureNo significant relationships.
Mom2B: a study of perinatal health via smartphone application and machine learning methods
Authors: Bilal A. , Bathula D. , Bränn E. , Fransson E. , Virk J. , Papadopoulos F. , Skalkidou A. 
Published: September 2022

IntroductionPeripartum depression (PPD) impacts around 12% of women globally and is a leading cause of maternal mortality. However, there are currently no accurate methods in use to identify women at high risk for depressive symptoms on an individual level. An initial study was done to assess the value of deep learning models to predict perinatal depression from women at six weeks postpartum. Clinical, demographic, and psychometric questionnaire data was obtained from the “Biology, Affect, Stress, Imaging and Cognition during Pregnancy and the Puerperium” (BASIC) cohort, collected from 2009-2018 in Uppsala, Sweden. An ensemble of artificial neural networks and decision trees-based classifiers with majority voting gave the best and balanced results, with nearly 75% accuracy. Predictive variables identified in this study were used to inform the development of the ongoing Swedish Mom2B study.ObjectivesThe aim of the Mom2be study is to use digital phenotyping data collected via the Mom2B mobile app to evaluate predictive models of the risk of perinatal depression.MethodsIn the Mom2B app, clinical, sociodemographic and psychometric information is collected through questionnaires, including the Edinburgh Postnatal Depression Scale (EPDS). Audio recordings are recurrently obtained upon prompts, and passive data from smartphone sensors and activity logs, reflecting social-media activity and mobility patterns. Subsequently, we will implement and evaluate advanced machine learning and deep learning models to predict the risk of PPD in the third pregnancy trimester, as well as during the early and late postpartum period, and identify variables with the strongest predictive value.ResultsAnalyses are ongoing.ConclusionsPending results.DisclosureNo significant relationships.