bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding humanitarian localization in Latin America—as local as possible: but how necessary?
Authors: Lucatello Simone , Gómez Oscar A. 
Published: June 2022

AbstractThis paper questions the pertinence of the humanitarian aid localization agenda in Latin America, at least in the narrow sense embraced by the 2016 World Humanitarian Summit. Localized support has been the standard practice in the region for decades, thanks to at least two correlated factors: the Monroe Doctrine limiting intervention to the USA and regional efforts to resist such intervention. Instead, humanitarian action in the region is an example of a particular way of understating localization, mainly specialized support to specific issues, no distinction between humanitarian or development divisions, and coexistence of different response approaches, synthesizing international and local experiences that intermingle with community practices and traditions, under national government leadership. Governments, together with NGOs, civil protection, and other relevant actors from international cooperation and development, engage in crises based on a long-standing tradition of risk management at national and regional levels. Fears of abuses hidden behind the non-interference principle, human rights activism, and disaster risk management approaches to emergencies created a complex ecosystem for humanitarian localization.
A scoping methodological review of simulation studies comparing statistical and machine learning approaches to risk prediction for time-to-event data
Authors: Smith Hayley , Sweeting Michael , Morris Tim , Crowther Michael J. 
Published: June 2022

AbstractBackgroundThere is substantial interest in the adaptation and application of so-called machine learning approaches to prognostic modelling of censored time-to-event data. These methods must be compared and evaluated against existing methods in a variety of scenarios to determine their predictive performance. A scoping review of how machine learning methods have been compared to traditional survival models is important to identify the comparisons that have been made and issues where they are lacking, biased towards one approach or misleading.MethodsWe conducted a scoping review of research articles published between 1 January 2000 and 2 December 2020 using PubMed. Eligible articles were those that used simulation studies to compare statistical and machine learning methods for risk prediction with a time-to-event outcome in a medical/healthcare setting. We focus on data-generating mechanisms (DGMs), the methods that have been compared, the estimands of the simulation studies, and the performance measures used to evaluate them.ResultsA total of ten articles were identified as eligible for the review. Six of the articles evaluated a method that was developed by the authors, four of which were machine learning methods, and the results almost always stated that this developed method’s performance was equivalent to or better than the other methods compared. Comparisons were often biased towards the novel approach, with the majority only comparing against a basic Cox proportional hazards model, and in scenarios where it is clear it would not perform well. In many of the articles reviewed, key information was unclear, such as the number of simulation repetitions and how performance measures were calculated.ConclusionIt is vital that method comparisons are unbiased and comprehensive, and this should be the goal even if realising it is difficult. Fully assessing how newly developed methods perform and how they compare to a variety of traditional statistical methods for prognostic modelling is imperative as these methods are already being applied in clinical contexts. Evaluations of the performance and usefulness of recently developed methods for risk prediction should be continued and reporting standards improved as these methods become increasingly popular.
Skin model for improving the reliability of the modified Rodnan skin score for systemic sclerosis
Authors: Pongkulkiat Patnarin , Thinkhamrop Bandit , Mahakkanukrauh Ajanee , Suwannaroj Siraphop , Foocharoen Chingching 
Published: June 2022

Abstract
Background
The gold standard for skin thickness assessment in systemic sclerosis (SSc) is the modified Rodnan skin score (mRSS); however, inter- and intra-rater variation can arise due to subjective methods and inexperience. The study aimed to determine the inter- and intra-rater variability of mRSS assessment using a skin model.

Methods
A comparative study was conducted between January and December 2020 at Srinagarind Hospital, Khon Kaen University, Thailand. Thirty-six skin sites of 8 SSc patients underwent mRSS assessment: 4 times the first day and 1 time over the next 4 weeks by the same 10 raters. No skin model for mRSS assessment was used for the first two assessments, while one was used for the remaining three rounds of assessments. The Latin square design and Kappa statistic were used to determine inter- and intra-rater variability.

Results
The kappa agreement for inter-rater variability improved when the skin model was used (from 0.4 to 0.5; 25%). The improvement in inter-rater variability was seen in the non-expert group, for which the kappa agreement rose from 0.3 to 0.5 (a change of 66.7%). Intra-rater variability did not change (kappa remained at 0.9), and the long-term effect of using a skin model slightly decreased by week 4 (Δkappa 0.9–0.7).

Conclusions
Using a skin model could be used to improve inter-rater variation in mRSS assessment, especially in the non-expert group. The model should be considered a reference for mRSS assessment in clinical practice and health education.
Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary sjogren syndrome: results of an epidemiologic systematic review/meta-analysis and a consensus guideline from the Brazilian Society of Rheumatology (articular, pulmonary and renal)
Authors: Trevisani Virginia Fernandes Moça , Pugliesi Alisson , Pasoto Sandra Gofinet , Lopes Maria Lucia Lemos , Guedes Lissiane Karine Noronha , Miyamoto Samira Tatiyama , Fernandes Marilena Leal Mesquita Silvestre , Fialho Sonia Cristina de Magalhães Souza , Pinheiro Aysa César , dos Santos Laura Caldas , Appenzeller Simone , Fidelix Tania , Ribeiro Sandra Lúcia Euzébio , de Brito Danielle Christinne Soares Egypto , Nayara Libório-Kimura Tatiana , Santos Maria Carmen Lopes Ferreira Silva , Cantali Diego Ustárroz , Gennari Juliana D’Agostino , Civile Vinicius Tassoni , Pinto Ana Carolina Pereira Nunes , Rocha-Filho César Ramos , Oliveira Fabiola Reis , da Rocha Aline Pereira , Valim Valeria 
Published: June 2022

AbstractSjogren's Syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, these systemic manifestations are not routinely evaluated and there is no homogenous approach to their diagnosis or evaluation. To close this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of these manifestations and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. The first part of this guideline summarizes the most important topics, and 11 recommendations are provided for the articular, pulmonary, and renal care of SS patients.
A new understanding of radiographic landmarks of the greater trochanter that indicate correct femoral rotation for measurement of femoral offset
Authors: Tatka Jakub , Delagrammaticas Dimitri , Kemler Bryson R. , Rosenberg Samuel I. , Brady Alex W. , Bryniarski Anna R. , Dornan Grant J. , Matta Joel M. 
Published: June 2022

Abstract
Objectives
To establish and validate a novel method for aligning femoral rotation to accurately measure femoral offset for preoperative templating and component sizing, and to identify the physical location of two radiographic lines utilized in the described method.

Materials and methods
Cadaveric proximal femurs were skeletonized and mounted to a biaxial load frame. Two radiographic lines along the greater trochanter were identified fluoroscopically. The femurs were rotated, and images were taken when the lines appeared superimposed, then in 2-degree increments to 10° of internal and external rotation, and at 30°. Radiographic femoral offset was calculated at each angle, and the maximum and aligned offsets were compared. Bone was removed until the radiographic lines disappeared, then a metal wire was inserted in place of the bone to confirm that the lines reappeared.

Results
The physical locations of the radiographic landmarks were on the anterior and posterior aspects of the greater trochanter. The mean true femoral offset was 38.2 mm (range, 30.5–46.3 mm). The mean aligned femoral offset was 37.3 mm (range, 29.3–46.3 mm), a 2.4% underestimation. The mean angle between aligned and true offset was 3.6° of external rotation (range, 10°ER-8°IR). Intra-rater intraclass correlation coefficient was 0.991.

Conclusion
Alignment of the radiographic lines created by the anterior and posterior aspects of the greater trochanter is a reliable and accurate rotational positioning method for measuring true femoral offset when using plain films or fluoroscopy, which can aid surgeons with preoperative templating and intraoperative component placement for total hip arthroplasty.
Insomnia and sleep quality among women during the perinatal period
Authors: El-Sherbeeny Nagla , El Tantawy Ashraf , Ibrahim Omneya , Elsayed Mona , El-Okda Noha , Hassan Haydy 
Published: June 2022

Abstract
Background
Insomnia is the most common sleep disorder affecting sleep quality and quality of life among women during the perinatal period. The aim of the study is to study the frequency of insomnia and sleep quality among perinatal women and their effect on quality of life: 131 participants; 64 perinatal and 67 control groups from the outpatient clinics of Suez Canal University Hospital, Ismailia, Egypt. DSM-5 criteria were used to diagnose insomnia. Sleep quality was assessed using PSQI, and SF-36 questionnaire was used for assessment of health-related quality of life.

Results
Insomnia was statistically significant higher among the perinatal group than the control; 28.1% and 10.4%, respectively (P < 0.05). The perinatal women had poor sleep quality as compared with the control group with a higher mean global PSQI score; 8.02 ± 2.97 and 4.97 ± 2.45, respectively (P < 0.05). The quality of life in the perinatal group was lower than the control group with scores of 54.96 ± 14.63 versus 62.34 ± 14.63, respectively.

Conclusions
Insomnia and poor sleep quality are found in higher frequency in perinatal women than their counterpart control. The study also showed a significant impact of these changes on maternal HRQoL.
Acquired childhood bladder melanosis
Authors: Varik Roma Subhash , Al-Adhani Mudher , Taghizadeh Arash 
Published: June 2022

Abstract
Background
Bladder melanosis is rare. It has previously been described only in the fifth decade of life or beyond; it has not been described in childhood. Previous descriptions have generally been case reports, and so the natural history is poorly understood. Urinary symptoms present at the time of cystoscopy have frequently been attributed to bladder melanosis. A possible suggested aetiology is aberrant migration of melanocyte migration during embryogenesis.

Case presentation
We present the first case of bladder melanosis in a child. He had been under our care since the age of 5 years with urinary incontinence and at that time, had undergone cystoscopy demonstrating normal bladder mucosa. A diagnosis of idiopathic detrusor overactivity with underactive voiding had been made. After other unsuccessful treatments, intravesical botulinum toxin was proposed. At the age of 13, repeat cystoscopy prior to botulinum toxin, demonstrated widespread pigmented areas in the bladder mucosa. Histology showed bladder melanosis. Our finding is important for several reasons. This is the first reported case of bladder melanosis to affect a child. The previous normal cystoscopy in our patient would refute the explanation that bladder melanosis is a congenital condition. Furthermore, the development of melanosis on the background of stable symptoms raises the possibility that the condition may be asymptomatic.

Conclusions
This unique finding of bladder melanosis in a child has provided further insight into this rare and poorly understood condition.
Extragonadal germ cell tumor presenting with spinal cord compression: a case report and literature review
Authors: Farah Roula A. , Matta Judy K. , Metri Aida A. , Bejjani-Doueihy Noha A. , Saikali Ibrahim C. 
Published: June 2022

Abstract
Background
Yolk sac tumor or endodermal sinus tumor is an uncommon malignant germ cell neoplasm. This tumor usually presents in childhood or young adulthood as a testicular or ovarian mass. Extragonadal sites such as mediastinal, intracranial, and sacrococcygeal have been described. A review of the literature revealed limited related cases. The clinical presentation, radiographic characteristics, operative findings, and patient outcomes are discussed.

Case presentation
We report the occurrence of a primary paraspinal germ cell tumor in a 28-month-old boy who presented with thoracic spinal cord compression. The patient presented with pain, weakness, paraplegia, and bowel and bladder disturbances.
MRI was done and showed a retroperitoneal and paravertebral mass invading the left diaphragmatic crus, the lateral neural foramen, and the posterior paravertebral muscles. Morphologic and immunohistochemical features were consistent with a germ cell tumor, namely an endodermal sinus tumor (yolk sac) of the epidural area. The final diagnosis was determined to be stage IV extragonadal germ cell tumor. The patient underwent emergency surgery consisting of T10–12 laminectomy and epidural mass resection with the release of the spinal cord compression and received chemotherapy consisting of cisplatin, bleomycin, and etoposide. After six cycles of chemotherapy, follow-up MRI showed complete resolution of the tumor. The patient has been in complete remission 16 years from his initial diagnosis. He still, however, has mild residual weakness in both lower extremities and some detrusor-sphincter dyssynergia.

Conclusion
Extragonadal germ cell tumors presenting with spinal cord compression are rare; however, they should be included in the differential diagnosis of every child younger than 3 years old who does not present with the typical features. Germ cell tumors are sensitive to platinum-based chemotherapy, and surgery should only be performed for spinal cord compression and for obtaining tissue biopsy for a definitive diagnosis. The sooner the decompression is done, the better neurological outcome is achieved. Long-term remission, and possibly cure, can be achieved with a multidisciplinary treatment strategy.
Pediatric biliary calculus disease: clinical spectrum, predisposing factors, and management outcome revisited
Authors: Addagatla Rajashekar , Kundal Vijay Kumar , Divya Gali , Debnath Pinaki Ranjan , Meena Atul Kumar , Kemwal Aarushi , Sen Amita 
Published: June 2022

Abstract
Background
Biliary calculus disease (BCD) is one of the most prevalent diseases and poses a significant burden to the health care system in adults. The prevalence of BCD in children and adolescents is about 0.1% and 0.6%, respectively. Although many factors have been attributed to BCD in children, exact etiopathogenesis is not clear. BCD has been extensively studied in adults, but not much literature is available in children. The current review was undertaken to study BCD in children focusing on the objectives like predisposing factors, various modes of presentation, and management outcome of BCD in children in the northern part of India.

Results
Out of 42 children, two children had a history of ceftriaxone therapy. Two underwent ileal resection. The mean reticulocyte count was 1.79%. None had G6PD deficiency or abnormal osmotic fragility test. Clinical presentation was right upper quadrant pain (n = 42, 100%), calculous cholecystitis (n = 8, 19.0%), and jaundice (n = 3, 7.14%). The majority (n = 26, 61.92%) were overweight. Only 16.6% (n = 7) children had normal body mass index (BMI), and 9.3% (n = 4) were obese. The mean BMI was 26.3 kg/m2. 85.5% of children frequently consume junk foods. The majority of calculi were GB calculi accounting for 92.8% (n = 39) whereas 7.1% (n = 3) children had CBD calculi. Thirty-five were managed by laparoscopic cholecystectomy, three were managed by non-operative management, and one was managed by open cholecystectomy; among the three cases of CBD calculi, two were managed by endoscopic retrograde cholangiopancreatography (ERCP), stenting, and CBD exploration and one was managed by ERCP sphincterotomy.

Conclusion
Diet and overweight both appear to be important risk factors for pediatric BCD. Drug-induced calculi can be safely observed.
Complications of surgical port-a-cath implantation in paediatric patients: a single institution experience
Authors: Al Hindi Saeed , Khalaf Zahra , Tan Abigail K. L. , Haider Fayza 
Published: June 2022

Abstract
Background
Implantable vascular access devices (IVADs) provide durable routes for administering long-term treatments in patients. However, their associated complications pose a problem. One technique variation that can influence complication rates is the method of securing the IVADs, which is either by ligation or a purse-string suture.

Objective
To compare the two port-a-cath securing techniques, ligation and purse string, in terms of complication rates and types.

Study design
We prospectively included 67 paediatric patients who had port-a-cath insertions secured either by ligation or a purse-string suture at Salmaniya Medical Complex in Bahrain from January 2018 to June 2021. We recorded demographics, diagnoses, port-a-cath site of insertion and securing technique, operative time, follow-up duration, and complications. Patients who had previous port-a-cath insertions or other chemotherapy lines were excluded.

Results
Port-a-caths were secured by ligation in 35 cases and by a purse-string suture in 32 cases. There were 58.9% males and 41.8% females; sex was not correlated with complications (P = 0.11). Patients’ ages ranged from 2 months to 13 years. The overall complication rate of port-a-cath insertions was 16.42%. Complications occurred in 25.7% of ligation-secured port-a-caths and 6.3% of purse-string-secured port-a-caths. In the ligation-secured IVADs, complications included malfunction, infections, removal difficulty and blockage, malposition, and haematoma. Meanwhile, only leakage occurred in the purse-string-secured IVADs.

Conclusion
The port-a-cath securing technique was significantly correlated with complication rates. The complication types and rates in purse-string-secured catheters were lower than those reported in the literature. Leakage was the only complication that occurred in purse-string-secured port-a-caths.
Perioperative use of antibiotics in full-thickness rectal biopsies for Hirschsprung’s disease
Authors: Schiellerup Nicolai Skov , Bjørn Niels , Linneman Anders , Ehlers Peter , Möller Sören , Qvist Niels , Ellebæk Mark Bremholm 
Published: June 2022

Abstract
Background
There is no consensus on the use of perioperative antibiotic in full-thickness rectal biopsies (FTB) in children suspected for Hirschsprung disease. The primary objective of this study was to examine the effect of perioperative antibiotics on infectious and overall complications rate in FTB performed in children under the age of 1 year.

Methods
A retrospective chart review. Two time periods were compared—one with and one without the routine use of perioperative antibiotics. The treatment included cefuroxime 100 mg/kg and metronidazole 20 mg/kg administered intravenously at anesthesia induction followed by peroral administration of amoxicillin 50 mg/kg with Clavulanic acid 12.5 mg/kg three times a day t.i.d. for 3 days postoperative.

Results
In the group with perioperative antibiotics the infectious complications rate was 3.3% compared to 13.4% in the group without (p = 0.03) with fever as the most common. The overall complication rate was 11.3% and 15.2%, respectively (p = 0.43).

Conclusion
Perioperative antibiotics significantly reduced the rate of infectious complications, but not the rate of overall complication rate after a full thickness rectal biopsy in children under the age of 1 year.
Pertuzumab Plus Trastuzumab for Treatment-Refractory HER2-Amplified Metastatic Colorectal Cancer: Comparison of the MyPathway Trial With a Real-World External Control Arm
Authors: Narita Yusuke , Yoshimoto Takuya , Namai Tomoyuki , Asakawa Takashi , Kawakami Satoe , Gower-Page Craig , Reyes-Rivera Irmarie , Patel Arisha , Nakamura Yoshiaki 
Published: June 2022

PURPOSE We compared overall survival (OS) in patients with human epidermal growth factor receptor 2 ( HER2)–amplified, treatment-refractory metastatic colorectal cancer (mCRC) receiving pertuzumab plus trastuzumab (PER-HER) in the phase IIa MyPathway multibasket study (ClinicalTrials.gov identifier: NCT02091141 ) with OS in those receiving routine clinical care in an electronic health record–derived external control arm. METHODS A noninterventional study was conducted using patient-level data from MyPathway participants receiving PER-HER and real-world patients with HER2-amplified treatment-refractory mCRC receiving routine clinical care. This study used a deidentified US-based clinico-genomic database (CGDB). For patients in the CGDB who met study eligibility criteria at multiple index dates (treatment initiation dates in the treatment-refractory setting), all eligible index dates were used for the analysis. Standardized mortality ratio weighting on the basis of propensity score derived a pseudopopulation (postweighting population) balancing key prognostic variables between arms. Multivariate Cox proportional hazards models were used for estimation of the hazard ratio (HR) in the primary OS analysis. A series of sensitivity analyses were conducted to investigate the robustness and consistency of the primary analysis. RESULTS The PER-HER arm comprised 57 patients enrolled in the MyPathway study by August 1, 2017 (data cutoff); the external control arm comprised 18 patients (27 index dates) with HER2-amplified mCRC who met the major MyPathway eligibility criteria in CGDB collected between 2011 and 2019. The estimated HR for OS from the multivariate Cox proportional hazards model in the postweighting population was 0.729 (95% CI, 0.184 to 3.900). The results of sensitivity analyses were consistent with the primary analysis in terms of the point estimate of HR. CONCLUSION Despite a small sample size, these findings suggest that PER-HER could have a potential OS benefit for this population.