bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular docking prediction and in vitro studies elucidate anti-inflammatory effect of Garcinia extract against inducible nitric oxide synthase and cyclooxygenase-2 targets
Authors: Kalita Anuradha , Das Manas , Das Bhabajyoti , Baro Momita Rani 
Published: March 2022

Abstract
Background
Garcinia is a tropical plant that has been traditionally used in medicinal folklore for its potential antioxidant, antibacterial, anti-hyperlipidemic, anti-diabetic, hepatoprotective, etc. In this study, methanolic extract of Garcinia herbal supplement (GME) and its important phytoconstituents (Garcinol and hydroxycitric acid) were evaluated for their inhibitory action against important inflammatory markers iNOS and COX-2 in lipopolysaccharide-induced RAW 264.7 cells. iNOS and COX-2 play a major role in the process of inflammation, and inhibition of these molecules will help to alleviate the inflammatory process. The cells were pre-treated with two doses of GME (115 µg/ml and 230 µg/ml); Ggarcinol (6 µM and 12 µM); hydroxycitric acid (17.5 µg/ml and 35 µg/ml) followed by stimulation with 1 µg/ml of LPS for 24 h.

Results
The results of the study demonstrated that Garcinia and its active components Garcinol and HCA play an important role in suppressing LPS-induced relative mRNA expression of iNOS, COX-2, and subsequent reduction in the levels of total nitric oxide and prostaglandinE2. Molecular docking analysis of Ggarcinol and HCA with iNOS and COX-2 proteins showed potent interactions with negative binding energies.

Conclusions
This study suggests that Garcinia possess anti-inflammatory activity thus providing a possibility for drug designing as iNOS and COX-2 inhibitor.

Graphical Abstract
Gynecologic Survivorship Tool: Development, Implementation, and Symptom Outcomes
Authors: Carter Jeanne , Abu-Rustum Nadeem R. , Saban Sally , Chen Ling Y. , Vickers Andrew J. , Tin Amy L. , Billanti Gabriela , Connors Nicole A. , Broach Vance , Brown Carol L. , Chi Dennis S. , Gardner Ginger J. , Goldfrank Deborah J. , Jewell Elizabeth L. , Leitao Mario M. , Long Roche Kara C. , Mueller Jennifer J. , Sonoda Yukio , Zivanovic Oliver 
Published: March 2022

PURPOSE To describe the development and implementation of a new digital health clinical tool (Gynecologic Survivorship Tool [GST]) for symptom management of women surgically treated for gynecologic cancer; to assess its feasibility; and to conduct a retrospective review of the data. MATERIALS AND METHODS The GST was developed on the basis of a comprehensive review of the literature, multidisciplinary expert opinion, and feedback from women with a history of gynecologic cancer. It is composed of 17 questions addressing six main categories—gynecologic health (abnormal bleeding/pain), lymphedema, vaginal/vulvar dryness, sexual health, menopause (hot flushes/sleep difficulties), and bowel/urinary issues. An electronic version using the Memorial Sloan Kettering Cancer Center Engage platform was piloted in two clinics for patients with endometrial or cervical cancer. Health information was generated into clinical summaries and identified concerns for actionable response. Associations of symptom and survey time point were assessed by longitudinal models using generalized estimating equations. RESULTS From January 1, 2019, to February 29, 2020, 3,357 GST assessments were assigned to 1,405 patients, with a 71% completion rate (90% within 5 minutes). Sixty-eight percent were performed at home via a patient portal, 32% at follow-ups using a clinic iPad. The most common symptoms were bowel problems, swelling/fluid, pain during examination, vaginal or vulvar dryness, and vaginal bleeding. Implementation challenges included improving patient compliance and ensuring that reports were reviewed by all clinical teams. We developed screening e-mails detailing patients whose assessments were due, planned training sessions for multidisciplinary teams, and incorporated feedback on methods for reviewing symptoms reports. CONCLUSION The GST demonstrated feasibility, a high completion rate, and minimal time commitment. It was an effective electronic reporting mechanism for patients, enabling the medical team to develop specific strategies for alleviating bothersome symptoms during follow-up.
Neurodiverse Afro-Fabulations: Pauline Hopkins’s Counterintelligence
Authors: Knadler Stephen 
Published: March 2022

Abstract“Neurodiverse Afro-Fabulations” focuses on the neglected cognitive biopolitics in post-Reconstruction debates over African American progress and full democratic citizenship, in order to trace an unmarked African American neurodiverse disability history, or the antiableist imagining of neurological, cognitive, and psychological variations that existed before and persisted alongside the emergence of modern evolutionary- and hereditary-based diagnostic categories of intelligence. At the same time, “Neurodiverse Afro-Fabulations” argues for the importance of an abjected Blackness in the critical genealogy of modern neurodiversity, which has largely been associated with recent movements to recognize people with autism or ADHD and has focused on the middle-class white child. Through an examination of Pauline Hopkins’s essay series for the Colored American Magazine, “Famous Women of the Negro Race” (1901–2), this essay first recovers Hopkins’s ambivalent relation to the compulsory neurotypicality of racial uplift politics. “Neurodiverse Afro-Fabulations” then turns to Hopkins’s novel Contending Forces (1900) to foreground how her fiction is interrupted by scenes of neurodiverse Afro-fabulation that do not simply refute claims of Black inferiority through a representational politics of counterfacts, but fabulate, exaggerate, and deliberately foreground eccentric, excessive, and “irrational” ways of knowing that have their roots in diasporic epistemologies. Ultimately, “Neurodiverse Afro-Fabulations” raises questions about the way an engagement with a history of Black neurodiversity affects how we think about the political, especially as antiblackness and cognitive disability have often served as overlapping technologies in the formation of a white liberal humanism.
Shouting Abuse, Harmless Jolly, and Promiscuous Flattery: Considering the Contours of Sexual Harassment at Macy's Department Store, 1910–1915
Authors: Keire Mara 
Published: March 2022

Abstract
As the white slavery scare peaked in the United States in the early 1910s, department stores consistently figured among the most menacing sites mentioned by muckrakers for corrupting women’s morals. Worried about the reputation of departments stores in general and Macy’s in particular, the Straus brothers commissioned an anti-vice association, the Committee of Fourteen, to investigate why shopgirls might “go wrong.” Three women went undercover at Macy’s and reported on their experiences as department store employees. Their collected reports exposed the micropolitics of power that made some departments difficult places for women to work. This article alternates between general discussions of department stores and their workplace culture and specific case studies detailing how two male managers abused their power and the limited ways in which women could respond.
Characterization of Electronic Properties of Titanium Atom in Heterogeneous Ziegler-Natta Catalyst Analyzed by Soft X-ray Emission Spectrometry (SXES)
Authors: Saito Masayoshi , Murata Masahide , Kataoka Takuo , Sakuda Yusuke , Takahashi Hideyuki 
Published: March 2022

Abstract
An advanced spectroscopic analysis by Soft X-ray Emission Spectrometry (SXES) was applied for the first time to the characterization of a heterogeneous Ziegler-Natta catalyst, which comprised TiCl4 and dibutylphthalate (DBP) supported on MgCl2. The high energy resolution capability of SXES made it possible to quantitatively detect outermost shell orbit signals of Lα at 452 eV and Lβ at 458 eV of Ti atom. These were assigned to Ti species interacting with DBP and MgCl2, respectively.
From the correlation between the signal intensity ratios and the catalytic performances, it was presumed that Ti species interacting with MgCl2 should work as active sites for propylene polymerization.
An efficient pose classification method for robotic grasping
Authors: Ji Wenlong , Lin Yunhan , Min Huasong 
Published: March 2022

Background: The unstructured environment, the different geometric shapes of objects, and the uncertainty of sensor noise have brought many challenges to robotic grasping. PointNetGPD (Grasp Pose Detection) which was published in 2019 proposes a point cloud-based grasping pose detection method, which detects reliable grasping poses from the point cloud, and provides an effective process to generate and evaluate grasping poses. However, PointNetGPD uses the point cloud inside the parallel-gripper and the network only uses three channels of information when classifying grasping poses. Methods: In order to improve the accuracy of grasping pose classification, the concept of grasping confidence region was proposed in this paper, which shows the hotspot area of the object can be grasped successfully, and there will be higher success rate when performing grasping in this area. Based on the concept of grasping confidence regions, the grasping dataset in PointNetGPD is improved, which can provide richer information to the classification network. Using our dataset, we trained a scoring network that can score the point cloud collected by the depth camera. We added this scoring network to the classification network of PointNetGPD, and carried out the experiment of grasping poses classification. Results: The experimental results show that the classification accuracy increases by 4% after calculating the score channel on the original dataset; the classification accuracy increases by nearly 1% after using the trained scoring network to score the original dataset. Conclusions: The concept of positive grasp center area is proposed in this paper. Based on this concept, we improve the dataset in PointNetGPD, and use this dataset to train a scoring network to add the score information to the point cloud. The experiments show that our proposed method can effectively improve the accuracy of grasping poses classification network.
Temporomandibular joints disorders (TMDs) prevalence and their relation to anxiety in dental students
Authors: Homeida Lujain , Felemban Emtenan , Kassar Wed , Ameen Mazen , Aldahlawi Salwa 
Published: March 2022

Background: Temporomandibular joint disorders (TMDs) are very common disorders affecting the population and causing pain. Researchers have reported a high prevalence of TMDs among university students due to increased distress. The aims of this study were to determine the frequency of TMDs in Umm al-Qura University (UQU) dental students using the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD), and to examine the relationship between anxiety, bruxism, and TMDs among those students. Methods: The DC/TMD pain screener questionnaire was completed by dental students. Students who reported TMD pain or had at least one positive TMD symptom were invited to the dental clinic for a full TMJ evaluation. History of bruxism was documented and an ultra-brief tool for detecting anxiety and depression (Patient Health Questionnaire-4 PHQ) was completed by all students. Results: A total of 240 students responded to the TMD pain screener in which 119 reported at least one TMJ symptom. Only 93 dental students presented to clinical examination in which 64.5% (n=60) of them had temporomandibular joint disorders. Disc displacement with reduction and local myalgia (38.7% & 32.25%, respectively) were the most frequent diagnosis. A total of 29% (n=27) of students had more than one diagnosis. Overall, 41 participants (44.09%) reported a positive response to the anxiety scale and (n=38) 40% of participants reported parafunctional habits. Both the history of bruxism and anxiety were significantly related to TMDs (P=0.0002) and also significantly higher in women of higher academic years (P≤0.01). Conclusions: This study found a high prevalence of TMDs among UQU dental students. Disc displacement with reduction was the most prevalent disorder. Bruxism and anxiety were associated with painful TMDs.
Do Hungarian multiple sclerosis care units fulfil international criteria?
Authors: Kokas Zsófia , Sandi Dániel , Fricska-Nagy Zsanett , Füvesi Judit , Biernacki Tamás , Köves Ágnes , Fazekas Ferenc , Birkás Adrienne Jóri , Katona Gabriella , Kovács Krisztina , Milanovich Dániel , Dobos Enikő , Kapás István , Jakab Gábor , Csépány Tünde , Bense Erzsébet , Mátyás Klotild , Rum Gábor , Szolnoki Zoltán , Deme István , Jobbágy Zita , Kriston Dávid , Gerócs Zsuzsanna , Diószeghy Péter , Bors László , Varga Adrián , Kerényi Levente , Molnár Gabriella , Kristóf Piroska , Nagy Zsuzsanna Ágnes , Sátori Mária , Imre Piroska , Péntek Szilvia , Klivényi Péter , Kincses Zsigmond Tamás , Vécsei László , Bencsik Krisztina 
Published: March 2022

A patients
Because of the past 3 decades’ extensive research, several disease modifying therapies became available, thus a paradigm change is multiple sclerosis care was necessary. In 2018 a therapeutic guideline was created recommending that treatment of persons with multiple sclerosis should take place in specified care units where the entire spectrum of disease modifying therapies is available, patient monitoring is ensured, and therapy side effects are detected and treated promptly. In 2019 multiple sclerosis care unit criteria were developed, emphasizing personnel and instrumental requirements to provide most professional care. However, no survey was conducted assessing the real-world adaptation of these criteria.

Objective
To assess whether Hungarian care units fulfil international criteria.

Methods
A self-report questionnaire was assembled based on international guidelines and sent to Hungarian care units focusing on 3 main aspects: personnel and instrumental background, disease-modifying therapy use, number of people living with multiple sclerosis receiving care in care units. Data on number of persons with multiple sclerosis were compared to Hungarian prevalence estimates. Descriptive statistics were used to analyse data.

Results
Out of 27 respondent care units, 3 fulfilled minimum requirements and 7 fulfilled minimum and recommended requirements. The least prevalent neighbouring specialties were spasticity and pain specialist, and neuro-ophthalmologist and oto-neurologist. Only 15 centres used all available disease modifying therapies. A total number of 7213 people with multiple sclerosis received care in 27 respondent centres. Compared to prevalence estimates, 2500 persons with multiple sclerosis did not receive multiple sclerosis specific care in Hungary.

Conclusion
Less than half of Hungarian care units provided sufficient care for people living with multiple sclerosis. Care units employing fewer neighbouring specialties, might have difficulties diagnosing and providing appropriate care for persons with multiple sclerosis, especially for people with progressive disease course, contributing to the reported low number of persons living with multiple sclerosis.
Making Worlds: Affect and Collectivity in Contemporary European Cinema, Claudia Breger (2020)
Authors: Pitsilidou Elena 
Published: March 2022

Review of: Making Worlds: Affect and Collectivity in Contemporary European Cinema, Claudia Breger (2020)
New York: Columbia University Press, 344pp., ISBN: 9780231194198 (pbk), $35.00, ISBN: 9780231194181 (hbk), $105.00
Hull Number Effect in Ship Using Conveyor on Ocean Waste Collection
Authors: Sugianto Erik , Winarno Arif , Indriyani Ratna , Horng Chen Jeng 
Published: March 2022

The increase in ocean waste continues to grow from year to year, especially plastic and solid waste. Various ocean waste collection ships using conveyors exist, both in the form of designs and already in operation, but there has been no research on how many hulls are suitable for ocean waste collectors. This study aims to choose between the three-ship models, namely monohull type U, catamaran type inner flat hull, and trimaran type symmetrical. Assessment is based on ship resistance which relates to fuel consumption and flow distribution relates to ocean waste collection. This research uses Computational Fluid Dynamics (CFD) method which produces resistance, fluid flow velocity contours, and fluid flow patterns. Numerical simulation is based on Reynolds Averaged Navier Stokes (RANS). The turbulent model uses the standard k-epsilon equation. Then the volume of fluid sub-models used is open channel flow. The number of eulerian phases is two. Moreover, formulation of the volume fraction parameters used is an implicit body force. The results show that monohull type U is better than others in easiest to bring ocean waste closer to the conveyor and smallest resistance force. Then symmetric trimaran is faster than others in making ocean waste flow to the conveyor.
Evolutionary dynamics of the severe acute respiratory syndrome coronavirus 2 genomes
Authors: Qian Zhaohui , Li Pei , Tang Xiaolu , Lu Jian 
Published: March 2022

Abstract
The coronavirus disease 2019 (COVID-19) pandemic has caused immense losses in human lives and the global economy and posed significant challenges for global public health. As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has evolved, thousands of single nucleotide variants (SNVs) have been identified across the viral genome. The roles of individual SNVs in the zoonotic origin, evolution, and transmission of SARS-CoV-2 have become the focus of many studies. This review summarizes recent comparative genomic analyses of SARS-CoV-2 and related coronaviruses (SC2r-CoVs) found in non-human animals, including delineation of SARS-CoV-2 lineages based on characteristic SNVs. We also discuss the current understanding of receptor-binding domain (RBD) evolution and characteristic mutations in variants of concern (VOCs) of SARS-CoV-2, as well as possible co-evolution between RBD and its receptor, angiotensin-converting enzyme 2 (ACE2). We propose that the interplay between SARS-CoV-2 and host RNA editing mechanisms might have partially resulted in the bias in nucleotide changes during SARS-CoV-2 evolution. Finally, we outline some current challenges, including difficulty in deciphering the complicated relationship between viral pathogenicity and infectivity of different variants, and monitoring transmission of SARS-CoV-2 between humans and animals as the pandemic progresses.
Separate Functional Subnetworks of Excitatory Neurons Show Preference to Periodic and Random Sound Structures
Authors: Mehra Muneshwar , Mukesh Adarsh , Bandyopadhyay Sharba 
Published: March 2022

Auditory cortex (ACX) neurons are sensitive to spectro-temporal sound patterns and violations in patterns induced by rare stimuli embedded within streams of sounds. We investigate the auditory cortical representation of repeated presentations of sequences of sounds with standard stimuli (common) with an embedded deviant (rare) stimulus in two conditions, Periodic (Fixed deviant position) or Random (Random deviant position). We used extracellular single-unit and two-photon Ca2+imaging recordings in layer 2/3 neurons of the mouse (Mus musculus) ACX of either sex. Population single-unit average responses increased over repetitions in the Random condition and were suppressed or did not change in the Periodic condition, showing general irregularity preference. A subset of neurons showed the opposite behavior, indicating regularity preference. Furthermore, pairwise noise correlations were higher in the Random condition than in the Periodic condition, suggesting a role of recurrent connections in the observed differential adaptation. Functional two-photon Ca2+imaging showed that excitatory (EX), and inhibitory (IN) neurons [parvalbumin-positive (PV) and somatostatin-positive (SOM)] also had different categories of long-term adaptation as observed with single-units. However, examination of functional connectivity between pairs of neurons of different categories showed that EX-PV connected pairs behaved opposite to the EX-EX and EX-SOM pairs, with more connections outside category in Random condition than Periodic condition. Finally, considering Regularity, Irregularity, and no preference of connected pairs of neurons showed that EX-EX and EX-SOM pairs were in largely separate functional subnetworks with different preferences, not EX-PV pairs. Thus, separate subnetworks underlie coding of periodic and random sound sequences.SIGNIFICANCE STATEMENTStudying how the auditory cortex (ACX) neurons respond to streams of sound sequences help us understand the importance of changes in dynamic acoustic noisy scenes around us. Humans and animals are sensitive to regularity and its violations in sound sequences. Psychophysical tasks in humans show that the auditory brain differentially responds to Periodic and Random structures, independent of the listener's attentional states. Here, we show that mouse ACX L2/3 neurons detect changes and respond differently to patterns over long-time scales. The differential functional connectivity profile obtained in response to two different sound contexts suggests the vital role of recurrent connections in the auditory cortical network. Furthermore, the excitatory-inhibitory neuronal interactions can contribute to detecting the changing sound patterns.
Seroprevalence of SARS-CoV-2 antibodies among primary healthcare workers in the Republic of Srpska, Bosnia & Herzegovina: A cross-sectional study
Authors: Knežević Darija , Petković Miroslav , Božić Ljiljana , Miljuš Nataša , Mijović Biljana , Aćimović Jela , Djaković-Dević Jelena , Puhalo-Sladoje Dragana , Mašić Srdjan , Spaić Dragan , Todorović Nevena , Pilipović-Broćeta Nataša , Petrović Verica , Bokonjić Dejan , Stojiljković Miloš P. , Škrbić Ranko 
Published: March 2022

Abstract
Healthcare workers (HCW) in primary healthcare centres in the Republic of Srpska, Bosnia and Herzegovina, are on the first combat line with COVID-19. This study aimed to assess the seroprevalence of SARS-CoV-2 among HCW at the primary healthcare centres and to analyse the risk exposure to COVID-19, clinical signs and vaccination status. A cross-sectional study was conducted among HCW at the selected primary healthcare centres between 19 March and 30 April 2021. Antibodies against the SARS-CoV-2 virus were detected by enzyme-linked immunosorbent assay (ELISA). A total of 1,023 HCW (mean age 45 years; 71% female) were included in the study. The anti-SARS-CoV-2 antibodies were detected in 69.5% of all participants. There was a significant difference in seropositivity among primary healthcare centres from different geographical regions. As many as 432 (42%) of all participants had confirmed COVID-19 symptoms before the study and, 84.8% of them were seropositive. This study showed that 702 primary HCW were vaccinated with any of these vaccines: Sputnik V, Sinopharm, Pfizer/Biontech. High titre of SARS-CoV-2 antibodies was found amongst those who received one (92.6%) or both (97.2%) doses of vaccines. In this study, we report high prevalence of SARS-CoV-2 antibody among HCW in primary healthcare in the Republic of Srpska, Bosnia and Herzegovina during the third pandemic wave.