bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Analysis of Cuproptosis-Related lncRNAs in Immune Infiltration and Prognosis in Hepatocellular Carcinoma
Authors: Liu Chunhua , Wu Simin , Lai Liying , Liu Jinyu , Guo Zhaofu , Ye Zegen 
Published: September 2022

Abstract
Background
Being among the most common malignancies worldwide, hepatocellular carcinoma (HCC) accounts now as the fourth primary reason for cancer death. The regulation of cell death is the most crucial step in tumor progression and has become a crucial target for nearly all therapeutic options. Cuproptosis is a lately discovered copper-dependent method of apoptosis regulation. However, its primary function in carcinogenesis is still unclear.
Results
We developed a signature consisted of four cuproptosis-related lncRNAs (AL133243.2, AL031985.3, AL137127.1, and SNHG18). Compared to the low-risk group, the high-risk group exhibited a poorer outcome. The cuproptosis-related lncRNA signature can estimate HCC patients’ fate independently. Tumorigenesis and immunological-related pathways were primarily enhanced in the high-risk group, as determined by GSEA. Immunotherapy and standard chemotherapy medications such as erlotinib and lapatinib were more suitable for low-risk patients, whereas sunitinib, paclitaxel, gemcitabine, and imatinib were more suitable for high-risk patients.
Conclusion
The prognostic signature may forecasting HCC patients’ prognosis and establishes the fundamental function of cuproptosis-related lncRNAs in HCC. Cuproptosis-related lncRNAs may perform an important part in the tumor immune microenvironment (TIME), making them a promising treatment for HCC patients.
Development of short tandem repeat (STR) and derived cleaved amplified polymorphic (dCAPS) markers for distinguishing species and varieties of the genus Panax in Vietnam
Authors: Dinh Xuan Tu , Mai Xuan Cuong , Nguyen Minh Ly 
Published: September 2022

Abstract
In this study, we developed a protocol for the authentication of P. vietnamensis var. vietnamensis (Ngoc Linh ginseng) by combining two molecular markers: short tandem repeat (STR) and derived cleaved amplified polymorphic sequences (dCAPS). STR markers: Pvm30 and Pvm31 were found in the chloroplast genome of P. vietnamensis var. vietnamensis. These markers were able to accurately identify P. stipuleanatus, P. vietnamensis var. fuscidiscus, and P. ginseng. P. vietnamensis var. vietnamensis and P. vietnamensis var. langbianensishad a high similarity of chloroplast genomic sequence (99.96%) leading to STR markers could not distinguish these two ginseng varieties. Therefore, dCAPS marker: PvmdCAPS was applied to compensate for the defect of the STR markers. From the alignment result of the matK coding sequences of these two varieties, PvmdCAPS primers were designed at the position of single nucleotide polymorphisms (SNP) at the 248th nucleotide and had the ability to discriminate between these two Panax varieties. In summary, the combination of STR and dCAPS was used to distinct Panax species in Vietnam, especially P. vietnamensis var. vietnamensis.
An On-demand Photonic Ising Machine with Simplified Hamiltonian Calculation by Phase-encoding and Intensity Detection
Authors: Ouyang Jiayi , Liao Yuxuan , Ma Zhiyao , Kong Deyang , Feng Xue , Zhang Xiang , Dong Xiaowen , Cui Kaiyu , Liu Fang , Zhang Wei , Huang Yidong 
Published: September 2022

Abstract

Photonic Ising machine is a new paradigm of optical computing, which is based on the characteristics of light wave propagation, parallel processing and low loss transmission. Thus, the process of solving the combinatorial optimization problems can be accelerated through photonic/optoelectronic devices. In this work, we have proposed and demonstrated the so-called Phase-Encoding and Intensity Detection Ising Annealer (PEIDIA) to solve arbitrary Ising problems on demand. The PEIDIA is based on the simulated annealing algorithm and requires only one step of optical linear transformation with simplified Hamiltonian calculation. With PEIDIA, the Ising spins are encoded on the phase term of the optical field and only intensity detection is required during the solving process. As a proof of principle, several 20-dimensional Ising problems have been solved with high ground state probability (0.98 within 1000 iterations for the antiferromagnetic cubic model, > 0.99 within 4000 iterations for two random spin-glass models, respectively).
Defining hospital surge capacities and regional breakpoints for mass critical casualties: the national MassCare indicator
Authors: AUBRION Antoine , EID Yassine , Lefevre-Scelles Antoine , Laquievre Antoine , VILLEDIEU Florence , REICHLING Anais , CORBIN Céline , MACREZ Richard , MORELLO Remy , GUITTET Lydia 
Published: September 2022

Abstract
Background
This study proposes a method for a national indicator of mass care capacities in crisis situations (MassCare).
Methods
MassCare was based on national recommendations, expert working groups, national administrative databases.
Results
MassCare corresponds to the number of patients who can be treated immediately and simultaneously by each primary care unit, according to the NATO triage scale. Experts distinguished 3 determinants: (A) primary care unit; (B) adult or child patient, (C) working or nonworking hours. For each, the maximum MassCare (Tmax) can be estimated using national administrative databases for each hospital. Then, several surveys of hospital panels are conducted to determine the available parts of facilities, β1 at time 0 (T0) and β2 at time + 3h (T3):
T0-MassCare-AXBXCX=β1 *Tmax-MassCare-AXBXCX
Thus, the structural capacities at T0 and T3 are estimated for each hospital with the average β observed in the panel. For critical surgical patients, the MassCare indicator is derived from the minimum of surgeons, anesthetists or nurse anesthetists, and operating rooms. For emergency department, the MassCare capacity is 2 severe patients per doctor and 2 nurses. The accessible capacities at one hour of transport from the crisis site define District-MassCare.
Conclusion:MassCare is a new metric method integrated in the National Crisis Guide.
A new distributed earthquake early warning communication protocol based on messaging
Authors: Ismail Fatma , Abdel-Kader Hala Mohamed , Soliman M. Sami , Hossam Aya 
Published: September 2022

Abstract
One of the most dangerous disasters in the world is an earthquake. Earthquake early warning systems should provide reliable warnings as fast as possible with the fewest false and missed warnings. Social networks, distributed networks, and real-time systems have become the most important components of the new computer era, the Internet of Things (IoT). This research presents the existing development status of an earthquake early warning system (EEWS) and proposes an open system communication protocol based on instant messaging via a distributed network for earthquake early warning by using Extensible Messaging and Presence Protocol (XMPP) as a lower layer. Approximately all current EEWS use a centralized approach but these systems suffer from a problem of a single point of failure. This proposed system not only reduces the communication time but also make the system more robust and reliable where if one or more node fails, a whole system can still survive and the system is open so it can easily communicate with other systems.
The experience of living alone as an older woman in the UK during the Covid pandemic: an Interpretative Phenomenological Analysis.
Authors: Forward Cat , Fox Pauline , Khan Hafiz. T. A. 
Published: September 2022

Abstract
Background and Objectives
More people are living alone across the life course: in later life this can have implications for practical and psychosocial support. The Covid pandemic emphasised the importance of this when the UK government restricted movement outside of households to limit the spread of disease. This had important ramifications regarding social contact and practical support. The objectives of this study were to explore the experience of older women living alone during this time, with a focus on health and wellbeing.
Research Design and Methods
This study used an Interpretative Phenomenological approach. Semi-structured interviews were undertaken with seven women (aged 65+), living alone in the UK. Interviews were carried out between May and October 2020. Interpretative Phenomenological Analysis was used to analyse the transcripts.
Results
Findings show that life course events shaped how living alone was experienced in later life. Convergences and divergences in lived experience were identified. Three superordinate themes emerged from the Interpretative Phenomenological Analysis: Productivity, Ownership, and Interconnectedness.
Discussion and Implications
Findings highlight the importance of life course events in shaping the experience of later life. They also provide a better understanding of the lived experience of living alone as an older woman, increasing knowledge of this group and how living alone can affect health and wellbeing. Implications for research and practice are discussed, such as the importance of recognising the specific support needs for this group in later life, and the need for further knowledge about groups whose needs are not met by standard practice.
Effect of Single-Walled Carbon Nanotubes on the Adsorption of Basic Red 12 Dye by Trimellitic Anhydride Isothiocyanate-Cross Linked Chitosan Hydrogel
Authors: Mohamed Nadia A. , Almarshed Mawaheb S. , Al-Harby Nouf F. 
Published: September 2022

AbstractA chitosan hydrogel cross-linked with the least amount of trimellitic anhydride isothiocyanate (H1) and filled with 0.6 wt% of Single-Walled Carbon Nanotubes (SWCNTs) (H1/SWCNTs) was synthesized. Its structure was proven via Fourier transform infrared (FTIR) spectrum, X-ray diffraction (XRD) pattern, Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM) observations. The adsorption capacity for Basic red 12 (BR 12) dye onto H1/SWCNTs at pH 7 and 25°C was 14.80 mg g-1 with a percent removal efficiency of 37.66% which were greater by 1.8 times than that obtained onto the parent hydrogel H1 (8.21 mg g-1and 20.90%, respectively). Its sorption capacity slightly enhanced with decreasing adsorption solution pH. The optimum adsorption capacity of 15.62 mg g-1 and the % removal efficiency of 39.76% were observed at pH 10 and 25°C. The adsorption of BR 12 dye by H1/SWCNTs at different temperatures and different dye solutions pH fitted to kinetic models of the pseudo-second order and the intraparticle diffusion. The adsorption isotherm for BR 12 dye by H1/SWCNTs fitted to the Langmuir isotherm model indicating the monolayer nature of adsorption. BR 12 dye adsorption onto H1/SWCNTs is an exothermic process. Thus, inclusion of SWCNTs into the matrices of functionalized chitosan hydrogel H1 improved its features. It is a suitable way to obtain a favorable composite having a highly performance adsorbing characteristic for cationic dyes removal.
Household Catastrophic Health Expenditure for COVID-19 during March-August 2021, in South India: A Cross-Sectional Study
Authors: Rajalakshmi Elumalai , Sasidharan Akhil , Bagepally Bhavani Shankara , Kumar Muthusamy Santhosh , Manickam Ponnaiah , S Selva Vinayagam T , P Sampath , K Parthipan 
Published: September 2022

Abstract
Background
The Coronavirus disease 2019 (COVID-19) pandemic increased the utilisation of healthcare services. Such utilization could lead to higher out-of-pocket expenditure (OOPE) and catastrophic health expenditures (CHE). We estimated OOPE and the proportion of households that experienced CHE by conducting a cross-sectional survey of 1200 randomly selected COVID-19.
Methods
A cross-sectional survey was conducted by telephonic interviews of 1200 randomly selected COVID-19 patients who tested positive between 1 March and 31 August 2021. We collected household-level information on demographics, income, expenditure, insurance coverage, direct medical and non-medical costs incurred toward COVID-19 management. We estimated the proportion of CHE with a 95% Confidence interval. Multivariate logistic regression was used to examine the association between the number of severe COVID-19 and CHE.
Results
The mean OOPE per household was INR 122,221 (92,744 to 51,698) [US$1,643 (1,247 to 2,040)]. Among households, 61.7% faced OOPE, and 25.8% experienced CHE due to COVID-19. The odds of facing CHE were high among the households; with a family member over 65 years [OR = 2.89 (2.03 to 4.12)], with a comorbid individual [OR = 3.38 (2.41 to 4.75)], in the lowest income quintile [OR = 1.82 (1.12 to 2.95)], any member visited private hospital [OR = 11.85 (7.68 to 18.27)]. The odds of having CHE in a household who have received insurance claims [OR = 5.8 (2.81 to 11.97)] were high. Households having one severe COVID-19 and more than one increased the risk of CHE by four-times [AOR = 4.33 (2.13–8.34)] and five-times [AOR = 5.10 (2.42–10.74)] respectively.
Conclusion
COVID-19 severity increases household OOPE and CHE. Strengthening the public healthcare and health insurance with higher health financing is indispensable for financial risk protection of households with severe COVID-19 from CHE.
Effect of titanium dioxide (TiO2) nanoparticles on the storability of onion (Allium cepa L.) seeds under ambient condition
Authors: Khan Subhadip , Dayal Abhinav , Thomas Neha , Shukla Pradeep Kumar 
Published: September 2022

AbstractTiO2nanoparticles are highly stable, ecofriendly in nature, having low cost, act as a photo catalyst also having antimicrobial properties. Considering the effect of TiO2nanoparticles on seeds, a study was conducted during March 2022 to June 2022 at Department of Genetics and Plant Breeding, SHUATS, Prayagraj (U.P). In this study onion seeds of variety Nasik Red N-53 were collected to investigate the effect of TiO2nanoparticles on the seedling characters as well as on the biochemical characters under storage in ambient conditions. Onion seeds were treated with different concentration of TiO2nanoparticles (10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130 and 140 ppm) along with control and stored in two containers; viz. tin container (C1) and aluminum foil pouch (C2). All the seedling parameters were evaluated every month during storage. The experiment was conducted in factorial CRD with 4 replications. The experimental result showed that the storage containers influenced the seedling characters of onion. Seeds stored in aluminum foil pouch (C2) exhibited highest seedling characters and highest enzymatic activities throughout the storage period and exhibited lowest moisture per cent (8.05%) and lowest electrical conductivity (0.970 dSm− 1) as compared to tin container at the end of 3 months of storage. A significant difference was observed with the seed treatments. Seed treated with TiO2nanoparticles @40ppm (T4) for 2 hours performed better in terms of seedling characters; viz. germination per cent, speed of germination, first count per cent, root length, shoot length, seedling length, fresh weight, dry weight, vigour indices, seed density and enzymatic activities; viz. dehydrogenase activity and catalase activity and recorded lowest moisture per cent (8.04%) and lowest electrical conductivity (0.951 dSm− 1) as compared to control after 3 months of storage. The study concluded that seed treated with TiO2@40 ppm and stored in aluminum foil pouch can be used to expand the storability of onion seeds under ambient condition.
Optimal Causal Access in Geo-Replicated Storage Systems
Authors: Lima Stanley , Araujo Filipe , Guerreiro Miguel de Oliveira , Correia Jaime , Bento Andre , Barbosa Raul 
Published: September 2022

Abstract
We consider a setting where applications, such as websites or games, need causal access to objects available in geo-replicated cloud data stores. Common ways of implementing causal consistency involve hiding objects while waiting for their dependencies or waiting for server replicas to synchronize. To minimize delays and retrieve objects faster, applications may try to reach different server replicas at once. This entails a cost because providers charge for each reading request, including reading misses where the causal copy of the object is unavailable. Therefore, latency and cost are conflicting goals, which we control by selecting where to read and when. We formulate this challenge as a multi-criteria optimization problem and propose five non-dominated reading strategies to solve it, four of which are Pareto optimal. We validate these solutions on the following real cloud storage services: AWS S3, DynamoDB and MongoDB. Savings of as much as 50% on reading costs, with no significant or even a positive impact on latency, demonstrate that both clients and cloud providers could benefit from richer services compatible with these retrieval strategies.
Microearthquakes in the Guadalajara Metropolitan Zone, Mexico: Evidence from Buried Active Faults in Tesistán Valley, Zapopan.
Authors: Quinteros-Cartaya Claudia Beatriz , Solorio-Magaña Guillermo , Núñez-Cornú Francisco Javier , Escalona-Alcázar Felipe , Núñez Diana 
Published: September 2022

Abstract
A temporary seismic network installed in September 2017 in La Primavera Caldera, next to the Guadalajara Metropolitan Zone (GMZ), recorded numerous events, ML ≤ 3.8, corresponding to background seismicity and swarms observed for four months. In this study, we located 188 tectonic microearthquakes from September 2017 to 1st January 2018, mainly in Tesistán Valley, north of GMZ. In addition, we identified 11 clusters of similar events from a spatio-temporal analysis and waveform cross-correlations. The microseismicity array suggests the possibility of synthetic faults; these are NE-SW and N-S oriented faults crossing Tesistán Valley, whose seismogenic depths are close to 10 km. Furthermore, most ML≥ 2.5 events and some clustered events are located in northeastern Tesistán, close to the NNE-SSW fault corresponding to the eastern edge of the Zapopan Graben, a structure evidenced by 2015-2016 seismicity. Moreover, seismicity recorded during 2020 by a recent local seismic network installed in Zapopan reaffirm that frequent microseismicity is related to active faults that cross Zapopan and Guadalajara cities. This seismicity in the northeast boundary of Jalisco Block is closely related to faults formed by Cenozoic deformation events that might be reactivated due to crustal arrangements. Our results demonstrate the existence of continuous seismicity in GMZ that, unfortunately, was not monitored for a more extended period. Active faults and the possibility of synthetic structures is a hypothesis that requires ongoing studies and seismic monitoring and thus contributes to assessing the seismic hazard in the GMZ, which is a crucial factor for urban planning.
Forensic seismologiy for an underwater explosion vis- à-vis the ROKS Cheonan Sinking
Authors: Kim So Gu 
Published: September 2022

Abstract

For a very shallow underwater explosion, spectral analysis is preferable to cepstral analysis to find characteristics of a bubble pulse and reverberation effects. Time-domain analyses show bubble pulses and bubble jets as well as positive polarities of the first P-wave arrivals on the vertical component, and spectral analyses also clearly reveal the bubble pulse and reverberation effects. The ROKS Cheonan sinking was a shallow underwater explosion that occurred near the surface showing a bubble jet characteristic resulting in splitting the ship into two pieces including a bubble pulse. The findings of a bubble jet and a toroidal bubble deformation including a bubble pulse are highlighted in this study. The ROKS Cheonan sinking took place off the Baengnyeong Island in the Yellow Sea of the Korean Peninsula at a depth of about 8 m in the sea depth of 44 m on March 26, 2010. The explosive charge weight was estimated at 136 kg TNT using the seismological analyses and boundary element method. The 136 kg TNT is equivalent to one of the abandoned land control mines (LCM) that were deployed near the Northern Limited Lines (NLL) in the Yellow Sea by the South Korean Navy in the late 1970s.
Epidemiologic Survey Around Dog Bites, Plateau State, Central Nigeria
Authors: LE LOGYANG , MP OLABODE , HALIRU H , UA RAYANNU , MB Mohammad Bolajoko 
Published: September 2022

Abstract
Rabies is a zoonotic viral fatal disease of warm-blooded animals and occurs due to the bites of animals like dogs, cats, hyenas, jackals against their victims. Rabies remains threat to more than half of the world’s population, killing more than 59,000 people yearly mostly in Asia and Africa whilst most of the victims are children. Domestic dogs are responsible for causing over 99% of all human cases. Rabies can be transmitted through biting, scratching wounds, licking of broken skin and mucous membrane from rabid animal saliva to humans and other animals. In this study, ten farmers were randomly chosen and participated from the list of willing farmers from 5 local government areas LGAs, making a total of 50 farmers from the Berom, Tarok and Fulani communities in Plateau state. The population of those farmers who had no form of education combine with those who had least form of education 29(58%) are higher than those who attended secondary and tertiary 21(42%). 36(72%) revealed that ruminants have been the major victim of dog bites cases in the various communities and only 8(16%) said dogs are the most victims. 25(50%) of the respondents says animal can survive and live a normal life after bitten by a dog and 40(80%) believe that human can survive and live a normal life after bitten by a dog. Only 25(50%) of the respondents take their human victims of dog bites to the hospital for proper medical attention; 13(52%) of them had no idea on what to do with their human victims to dog bites before visits to the hospital, 5(20%) wash and dress the wounds of dog bites only and 6(28%) of the respondents’ resorts to using traditional methods of caring to dog bites wounds before hospital visits. In conclusion, this present study revealed that dog bite is an indiscriminate public health menace in both humans and animals, with ruminants being the most affected. Majority of the farmers had no idea on what to do with the wounds of dog bite on humans and their animals and this require for more public enlightenment/awareness about the fatality of the disease, its transmission and how the virus persists amongst human and animal populations. The dangers and risks, dog bites pose to the public health in any given community must be clearly explained to the public across all communities in the state and the whole country.