bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corneal Deformation Response in Patients With keratoconus and in Healthy Subjects
Authors: Huang Wenbin , Yu Hanyang , Fan Hongming , Ding Hui , Zhong Tan , Yang Zhenduo , Nie Ke , Ouyang Bowen , Wei Qi , Zhong Xingwu 
Published: June 2022

Abstract
Background
To compare the corneal deformation response between patients with keratoconus and healthy subjects and to identify potential characteristics associated with corneal response parameters.
Methods
This case-control study included a total of 40 keratoconus patients (40 eyes) and 40 age- and sex-matched healthy subjects (40 eyes) whose central corneal thickness (CCT) was less than 500 µm. Pentacam HR and Corvis ST were used to measure the corneal topographies and the corneal deformation response parameters.
Results
No significant difference was found in the age, sex, laterality distribution, IOP, and CCT between the keratoconus group and healthy controls. The keratoconus eyes had smaller TCT than the healthy controls (p < 0.001), as well as a greater anterior Kmax, posterior Kmax, anterior corneal astigmatism, posterior corneal astigmatism, and posterior maximum elevation (all p < 0.001). The A2l, A2V, and PD were similar between the two groups. The CCR were lower in the keratoconus group, whereas A1L, A1V, and DA were greater in the keratoconus group than in the healthy controls (all P < 0.05). In keratoconus patients, CCR was significantly associated with TCT. A1V was significantly correlated with anterior and posterior corneal astigmatism. Moreover, A2V, CCR, and DA were significantly correlated with posterior maximum elevation. No associations were detected between corneal response parameters and any potential factors in healthy controls.
Conclusions
Keratoconus eyes showed significant changes in the mechanical properties of the cornea. We hypothesize that local or uneven weakness of the cornea in keratoconus would significantly change all corneal biomechanical properties.
Relationship between COVID-19 and headache: evidence from an infodemiological analysis
Authors: Mattiuzzi Camilla , Lippi Giuseppe 
Published: June 2022

Abstract
Background: There is emerging evidence that headache may be a frequent common symptom in patients diagnosed with coronavirus disease 2019 (COVID-19), thus paving the way to further epidemiological studies to better evaluate this potential association.Methods: We conducted an electronic search in Google Trends with the keyword “headache” (i.e., “mal di testa”, in Italian), with the geographical area set to “Italy” and the search period comprised between February 2020 and June 2022. The number of new weekly diagnoses of COVID-19 was also captured using the official statistics published by the Italian Ministry of Health. The potential association between Google searches for headache and new COVID-19 diagnoses was verified with Spearman’s correlation.Results: The number of new COVID-19 diagnoses and Google searches for headache in Italy followed a similar trend, nearly overlapping, and yielding a significant correlation during the same week (r=0.56; 95%CI, 0.42-0.67; p<0.001). An even better correlation was found when the number of new COVID-19 diagnoses was correlated with the Google searches for headache in the preceding week (r=0.60; 95%CI, 0.47-0.70; p<0.001).Conclusion: Web interest and, therefore, burden of headache is significantly correlated with the number of newly diagnosed cases of COVID-19 in Italy. This evidence may hence lead the way to using an infodemiological analysis based on the symptom “headache” for timely predicting future trends of COVID-19 outbreaks.
Bisequent Calculus for Four-Valued Quasi-Relevant Logics; Cut Elimination and Interpolation
Authors: Indrzejczak Andrzej 
Published: June 2022

Abstract
We present a uniform syntactical characterization of the class of quasi-relevant logics which are four-valued extensions of the basic relevant logic B of Meyer and Routley. All these logics are obtained by the addition of suitable quasi-relevant implications to the four-valued logic of First Degree Entailment FDE. So far they were characterised axiomatically and semantically in several ways but did not obtain a special proof-theoretic treatment. To this aim a generalised form of sequent calculus called bisequent calculus (BSC) is applied. In BSC rules operate on the ordered pairs of ordinary sequents. It may be treated as the weakest kind of system in the rich family of generalised sequent calculi operating on items which are some collections of ordinary sequents, like hypersequents or nested sequents. It is shown that all logics under consideration have cut-free characterisation in BSC which satisfies the subformula property and the interpolation theorem.
Dietary lactoferrin supplementation improves growth performance and intestinal health of juvenile orange-spotted groupers (Epinephelus coioides)
Authors: Song Tao , Qin Yingmei , Ke Liner , Wang Xuexi , Wang Kun , Sun Yunzhang , Ye Jidan 
Published: June 2022

Abstract
A 56-day feeding trial was conducted to investigate the effects of dietary lactoferrin (LF) supplementation on growth performance and intestinal health of juvenile orange-spotted groupers (Epinephelus coioides) fed high soybean meal (SBM) diets. The control diet (FM) and high soybean meal diet (SBM60) were prepared to contain 48% protein and 11% fat. Three inclusion levels of 2, 6, and 10 g/kg LF were added into the SBM diets to prepare three experimental diets (recorded as LF2, LF6, and LF10, respectively). The results showed that supplementation of LF in SBM diets increased growth rate in a dose dependent manner. However, feed utilization, hepatosomatic index, whole-body proximate composition and the abundance and diversity of intestinal microbiota did not vary across dietary treatments (P > 0.05). After dietary intervention with LF, the contents of intestinal malondialdehyde, endotoxin, and D-lactic acid, as well as plasma low density lipoprotein cholesterol, high density lipoprotein cholesterol and total cholesterol were lower, and the intestinal activities of glutathione peroxidase, lipase, trypsin, and protease were higher in LF2-LF10 groups than that in SBM60 group (P < 0.05). Supplementation of LF in SBM diets increased the muscle layer thickness of middle and distal intestine and the mucosal fold length of middle intestine vs SBM60 diet. Furthermore, supplementation of LF in SBM diets resulted in an up-regulation of the mRNA levels for IL-10 and TGF-β1 genes and a down-regulation of the mRNA levels of IL-1β, IL-12, IL-8, and TNF-α genes vs SBM60 diet (P < 0.05). The above results showed that dietary LF intervention could improve the growth and alleviate soybean meal induced enteritis in juvenile orange-spotted groupers. The dietary appropriate level of LF was at 5.8 g/kg, through the regression analysis of percent weight gain against dietary LF inclusion levels.
The efficacy of silica nanospheres decorated with photosensitizers for oryzaephilus surinamensis and lasioderma serricorne control
Authors: Attia Radwa G. , Rizk Salwa A. , Radwan Ahmed 
Published: June 2022

Abstract
Saw-toothed grain beetle Oryzaephilus surinamensis and cigarette beetle Lasioderma serricorne are major stored grain pests. The development of more efficient and persistent silica nanospheres decorated with photosensitizers is emerging as a promising alternative to traditional synthetic chemical insecticides. The characterization of silica nanosphere photosensitizer rose bengal (SNP1), silica nanosphere photosensitizer methylene blue (SNP2), silica nanospheres (SNs), rose bengal (RB), and methylene blue (MB) were estimated. The conjugation process between SNs and photosensitizers was confirmed by using X-ray diffraction, fourier transforms infrared spectroscopic, and UV-visible spectrophotometry. The structural morphology of SNP1, SNP2 and SNs was investigated using field emission scanning electron microscopy. Bioassays were also carried out to evaluate the effects of sub-lethal concentrations (LC50) of the five substances against O. surinamensis and l. serricorne. As compared by LC50 values, the order of toxicity was SNP1 ˃ SNP2 ˃ SNs ˃ RB ˃ MB after three hours of exposure to sunlight.
The effects of the COVID-19 pandemic on the epidemiology of pediatric severe sepsis in the Shandong Province of China from 2019 to 2020
Authors: Wang Yujuan , Li Jingwen , Chen Jie , Lu Guoping , Zhang Yucai , Xue Fuzhong , Jin Youpeng 
Published: June 2022

Abstract
Background: To investigate the impact of the coronavirus disease (COVID-19) pandemic on the prevalence and outcome of pediatric severe sepsis in the Shandong Province of China from 2019 to 2020.Methods: Using the 2019-2020 data from the Interconnected Electronic Medical Record Data Sets of the Shandong Population Health Information Platform, a retrospective study was conducted to examine visits by patients aged up to 18 years who were diagnosed with severe sepsis or septic shock or bacterial/fungal infections combined with acute organ dysfunctions. The prevalence and mortality of these patients between 2019 and 2020 were compared. Results: There were no confirmed positive cases of COVID-19 among these patients. The number of cases and the yearly incidence rate of pediatric severe sepsis in hospitals decreased significantly (1098 vs 2143, 1.62/1000 vs 1.78/1000, P=0.01) along with the total number of hospitalized children (679608 vs 1204496) in the Shandong Province of China in 2020 compared to 2019. The hospital mortality of pediatric severe sepsis did not change significantly as it varied from 11.48% in 2019 to 12.84% in 2020 (P=0.283). The hospital costs, the proportion of pediatric severe sepsis admitted to ICU as well as those requiring mechanical ventilation increased in 2020 compared to 2019.Conclusion: After the outbreak of the COVID-19 pandemic, the number and the yearly incidence rate of pediatric severe sepsis among hospitalized children in the Shandong province decreased significantly, while the hospital mortality did not change significantly. The COVID-19 pandemic seemingly impacted favorably the epidemiology of pediatric severe sepsis.
Revisiting Janzen's mountain passes hypothesis from a microbial perspective: why tropical mountains are so biodiverse?
Authors: Zhang Yazhou , Crowther Thomas W. , Xu Shijia , Hogan J. Aaron , Zhao Rensheng , Song Pengfei , Cui Mufeng , Song Xiaoyang , Cao Min , Yang Jie 
Published: June 2022

Abstract
Background: Although it is well known that microbial communities are extremely diverse, how and why levels of biodiversity are generated and maintained are enduring ecological questions. Janzen’s mountain passes hypothesis assumes that the relatively stable climate regimes of tropical mountains means that species have narrower ranges than montane regions in cooler climates, allowing disproportionately high levels of species coexistence and diversity. We test this hypothesis for soil bacteria and fungi, to explore the relative importance of niche and neutral dynamics in governing of microbial diversity on mountains. Results: We found that the tropical mountain showed greater climatic barriers that effectively limited the dispersal of microbes but had no similar soil barriers. Our results show that tropical mountains have higher β-diversity and greater species turnover rates along elevations than subtropical and subalpine mountains both for fungi and bacteria. β-diversity patterns along elevational gradients are mainly shaped by dispersal limitation coupled with ecological drift and homogeneous selection, particularly in the tropics. Conclusions: Therefore, stronger effects of climatic barriers in tropical mountains in conjunction with biogeographic species distributions and dispersal limitation permit greater biological diversity of soil bacteria and fungi, which supports the predictions of Janzen’s hypothesis. This study advances our understanding of mechanisms underpinning the community assembly of soil microorganisms by demonstrating that climatic-dependent dispersal limitations also operate in tropical soil microbial communities.
Ultralight and superelastic nanofiber aerogels with in-situ loaded polypyrrole for high-efficient Cr(VI) adsorption
Authors: Li Dan , Liu Huipeng , Wang Ziwen , Zhang Zeqian , Wang Chengzhong , Zhao Biao , Pan Kai 
Published: June 2022

Abstract
Constructing 3-D nanomaterial-based adsorbents with good mechanical properties has attracted increasing attention. This paper reports a simple strategy to prepare ultralight and superelastic 3-D aerogels as efficient adsorbents for heavy metal Cr(VI) in wastewater by in-situ loading of polypyrrole on cellulose acetate nanofibers followed by freeze-drying method. By the way, the cellulose acetate nanofibers are prepared by electrospinning. The obtained aerogel shows obvious 3-D porous and cross-linked structure, in which polypyrrole is uniformly coated on the nanofiber surface. The aerogel shows good mechanical properties with high compressive strength of 14.49 kPa, and can be processed into any desired shape. Due to the advantages of large specific surface area and high porosity, the maximum adsorption capacity of Cr(VI) in wastewater can reach up to 244.65 mg/g. The adsorption process can be described by pseudo-second-order kinetic model and Langmuir isotherm adsorption model, and the reduction-adsorption mechanism of polypyrrole on Cr(VI) is also studied. The present work proposes a high-quality nanofiber aerogel for efficiently adsorbing Cr(VI), which may also hold good potentials in the field of assembled adsorption.
OSeMOSYS Global: An open-source, open data global electricity system model generator
Authors: Barnes Trevor , Shivakumar Abhishek , Brinkerink Maarten , Niet Taco 
Published: June 2022

Abstract
This paper describes OSeMOSYS Global, an open-source, open-data model generator for creating globalelectricity system models for an active global modelling community. This version of the model generator is freelyavailable and can be used to create interconnected electricity system models for both the entire globe and forany geographically diverse subset of the globe. Compared to other existing global models, OSeMOSYS Globalallows for full user flexibility in determining the time slice structure and geographic scope of the model anddatasets, and is built using the widely used fully open-source OSeMOSYS energy system model. This paperdescribes the data sources, structure and use of OSeMOSYS Global, and provides illustrative workflow results.
Detection of SARS CoV-2 reinfections by rapid inexpensive techniques
Authors: Niranji Sherko Subhan , Al-Jaf Sirwan M.A. 
Published: June 2022

Abstract
New SARS-CoV-2 infections are difficult to be verified, whether they are reinfections or persistent infections. The most prominent factors used for differentiating reinfections from persistent infections are whole-genome sequencing and phylogenetic analyses that require time and funds, which may not be feasible in most developing countries. This study explores reinfections with COVID-19 that harbors D614G and N501Y mutations by rapid inexpensive methods. It exploits the previously developed rapid economic methods that identified both D614G and N501Y mutations in clinical samples using real-time reverse transcriptase polymerase chain reaction (rRT-PCR) probes and conventional PCR specific primers. In the present study, an immunocompetent patient has been found with a SARS-CoV-2 N501Y reinfection without comorbidities. According to the obtained results, this study suggests that the initial infection was due to a variant that contained only D614G mutation whereas the reinfection was potentially a result of alpha variant contained three mutations confirmed by DNA sequencing, including D614G, N501Y, and A570D mutations.These techniques will support rapid detection of SARS-CoV-2 reinfections through the identification of common spike mutations in the developing countries where sequencing tools are unavailable.Furthermore, seven cases of reinfections were also confirmed by these methods. These rapid methods can also be applied to large samples of reinfections that may increase our understanding epidemiology of the pandemic.
Hubungan Asupan Vitamin E dan Vitamin C dengan Kadar Kolesterol Total pada Pasien Hiperkolesterolemia
Authors: Damayanti Amilia Yuni , Anjana Akfina Rizki , Darni Joyeti 
Published: June 2022

AbstractThis study aims to determine the correlation between vitamin E and vitamin C intake with total cholesterol levels in the hypercholesterolemic patient. The research design was cross-sectional type with 30 samples whose diagnosed with hypercholesterolemia in January 2019 at Tlogosari Kulon Health Center, Semarang. The intake of vitamin E and vitamin C was obtained using a semi-quantitative food frequency questionnaire (SQFFQ). Total cholesterol data were collected from the result of the patient’s blood test with cholesterol levels above 200 mg/dl. The analysis used was univariate and bivariate analysis to determine the correlation between the intake of vitamin E and vitamin C with total cholesterol levels. The bivariate analysis used the Spearman Rank. The average intake of vitamin C and E of respondents is classified as less, namely 34.51 mg and 0.12 mg in a day. There was no significant correlation between vitamin E intake and total cholesterol levels (p-value =0.13 ), there was no significant correlation between vitamin C intake and total cholesterol levels (p-value =0.39). Vitamin E and vitamin C intake are not related to total cholesterol levels in hypercholesterolemic patients. AbstrakPenelitian ini bertujuan untuk mengetahui hubungan antara asupan vitamin E dan vitamin C dengan kadar kolesterol total pada pasien yang mengalami Hiperkolesterolemia. Desain penelitian adalah cross sectional dengan (n=30) yang baru didiagnosa Hiperkolesterol pada bulan Januari 2019 di Puskesmas Tlogosari Kulon Semarang. Asupan vitamin E dan vitamin C diperoleh dengan menggunakan semi quantitative food frequency questionnaire (SQFFQ). Data kolesterol total diperoleh dari hasil tes laboratorium kimia darah pasien dengan kadar kolesterol di atas 200 mg/dl. Analisis yang digunakan adalah analisis univariat dan bivariat untuk mengetahui hubungan antara asupan vitamin E dan vitamin C dengan kadar kolesterol total. Analisis univariat yang digunakan adalah uji normalitas dan bivariat adalah uji Spearman Rank. Rata-rata asupan vitamin C dan E responden tergolong kurang, yaitu 34,51 mg dan 0,12 mg per hari. Tidak ada hubungann signifikan antara asupan vitamin E dengan kadar kolesterol total (p-value =0,13 ), tidak ada hubungan signifikan antara asupan vitamin C dengan kadar kolesterol total (p-value =0,39). Asupan vitamin E dan vitamin C tidak berhubungan dengan kadar kolesterol total pada pasien Hiperkolesterolemia.
Makanan Pendamping Asi, Ketahanan Pangan, dan Status Gizi Balita di Bekasi
Authors: Dewi Selvi Purnama , Fayasari Adhila 
Published: June 2022

AbstractThis study aims to analyze the relationship between complementary feeding, food security, and nutritional status (Weight-for-age (WAZ)) of children aged 6-59 months in Bekasi. This study used cross sectional design of 135 pairs of mothers and children aged 6-59 months in the Jatiluhur Primary Health Center, Bekasi City. Provision of complementary feeding and food diversity were collected using questionnaire. Food Security was collected using (Household Food Insecurity Access Scale- HFIAS) questionnaire. Anthropometic data was collected using weighing scale and was converted into z-score using WHO-Anthroplus software. Data were analysed by chi-square/Fischer exact test with 5% significant p value. The result showed that 86 (63.7%) children were underweight (z-score -1 SD). There was a significant relation between timing of introduction complementary feeding and nutritionaatus (p = 0.031). On the other hand, there was no significant relation between food security and food diversity with nutritional status. This study showed that that the timing of introduction complementary feeding is significantly related to the nutritional status of children in Bekasi. AbstrakPenelitian ini bertujuan untuk menganalisis hubungan pemberian makanan pendamping ASI dan ketahanan pangan dengan status gizi balita (BB/U) usia 6-59 bulan di puskesmas wilayah Kota Bekasi. Penelitian ini menggunakan desain cross sectional pada 135 ibu dan balita usia 6-59 bulan di wilayah Puskemas Jatiluhur, Bekasi. Data karakteristik, keragaman pangan dan riwayat pemberian MP-ASI diukur menggunakan kuesioner, ketahanan Pangan diukur dengan kuesioner Household Food Insecurity Access Scale- (HFIAS). Data status gizi didapatkan dengan pengukuran berat badan kemudian diolah menggunakan software WHO-Antrhoplus. Analisis statistik yang digunakan adalah uji chi-square/fischer exact dengan tingkat kesalahan 5%. Sebanyak 86 balita (63,7%) memiliki status gizi kurang (z-score -1 SD). Terdapat hubungan antara waktu pemberian MP-ASI dengan status gizi balita BB/U ( p = 0,031). Tidak terdapat hubungan ketahanan pangan, keragaman pangan, frekuensi dan jenis pemberian MP-ASI dengan status gizi balita BB/U (p=0,443). Berdasarkan penelitian yang dilakukan, hanya waktu pemberian MP-ASI yang terkait dengan status gizi balit di bekasi.
Hubungan Asupan Energi, Lemak, Serat, dan Aktivitas Fisik dengan Visceral Fat Pada Pegawai Uin Walisongo Semarang
Authors: Kurniasanti Pradipta 
Published: June 2022

AbstractThis study aims to determine the relation between energy intake, fat, fiber, and physical activity to visceral fat in Universitas Islam Negeri Walisongo employees. This study involved 165 educational employees using simple random sampling technique. Data collection was conducted directly using a physical activity questionnaire, 3x24 hour food recall, and anthropometric data. The data was then statistically processed using Microsoft Excel, Nutrisurvey, and the SPSS. The data analysis were carried out using the Kolmogorov-Smirnov test, Pearson Product Moment Correlation analysis, and Spearman Rank Correlation. Based on the results of the Pearson correlative test, it was found that there was a relationship between energy intake and visceral fat (p value 0.05), while for fat intake, fiber, and physical activity did not have a significant relationship with visceral fat (p 0.05). The results of this study indicate that energy intake is positively correlated with the visceral fat while intake of fat, fiber, and physical activity is not correlated with the visceral fat. AbstrakPenelitian ini bertujuan untuk mengetahui hubungan asupan energi, lemak, serat dan aktivitas fisik dengan visceral fat pada pegawai Universitas Islam Negeri Walisongo. Responden pada penelitian ini adalah 165 pegawai tenaga kependidikan dengan menggunakan simple random sampling. Pengambilan data dilakukan secara langsung menggunakan kuesioner aktivitas fisik, food recall 3x24 jam, dan pengukuran data antropometri. Data kemudian diolah secara statistik menggunakan Microsoft Excel, Nutrisurvey, dan Statistical Program for Social Science (SPSS). Analisis statistika yang dilakukan adalah uji normalitas dan uji korelasi. Uji normalitas data dengan uji Kolmogorov-Smirnov, kemudian dilanjut uji analisa Korelasi Product Moment Pearson. Berdasarkan uji korelatif Pearson didapatkan hasil bahwa terdapat hubungan antara asupan energi dengan visceral fat yang dibuktikan dengan nilai p 0,05. Adapun untuk asupan lemak, serat, dan aktivitas fisik tidak memiliki hubungan yang signifikan dengan visceral fat (p 0,05). Hasil penelitian ini menunjukkan bahwa hanya asupan energi yang berkorelasi positif dengan visceral fat sedangkan asupan lemak, serat, dan aktivitas fisik tidak berkorelasi.