bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual ambient plasma source ionization mass spectrometry for the rapid detection of trace sterols in urban water
Authors: Zhao Gaosheng , Chu Fengjian , Zhou Jianguang 
Published: January 2022

AbstractA direct analytical method based on dual ambient plasma ion source tandem mass spectrometry was used for the simultaneous determination of four sterols in the environment. This technology has very high sensitivity and the method detects the four sterols in methanol–water (1:3) solutions with limits of detection (LOD) and limits of quantification (LOQ) ranging from 1.2 ng/L to 6.9 ng/L and 7.6 ng/L to 10.0 ng/L, respectively. The method was also used to test water quality at three locations within the city and successfully detected all four sterols at very low concentrations. The dual plasma source tandem mass spectrometry technique is extremely simple, rapid, sensitive and highly efficient compared to other traditional methods, providing a useful screening tool for sterols in water.
Work–life balance and social support: The influence on work engagement in the Sixth European Working Conditions Survey
Authors: Inggamara Akistya , Pierewan Adi C. , Ayriza Yulia 
Published: January 2022

AbstractThis study examined the influence of work–life balance and social support on work engagement using the big data of the Sixth European Working Conditions Survey. The data included 43,850 respondents from many countries in Europe. In this sample, work–life balance and social support are positively related to work engagement. Findings suggest that organizations should provide a resourceful work environment and consider the balance of their time at work and personal life to achieve high work engagement.
Relationships between tendon structure and clinical impairments in patients with patellar tendinopathy
Authors: Sprague Andrew L. , Couppé Christian , Pohlig Ryan T. , Cortes Daniel C. , Silbernagel Karin Grävare 
Published: January 2022

AbstractThe clinical relevance of altered tendon structure in patellar tendinopathy is contested since structural change persists after symptom resolution. The purpose of this study was to explore the relationships between tendon structure and clinical impairments in patellar tendinopathy. In this retrospective, secondary analysis of individuals with patellar tendinopathy (n = 41), tendon structure (thickness, cross‐sectional area [CSA], shear modulus, and viscosity), symptom severity, lower extremity function (counter‐movement jump [CMJ] height), and quadriceps muscle performance (knee extension force and central activation ratio [CAR]) were recorded for the symptomatic limb. Relationships among structure, symptom severity, lower extremity function, and quadriceps muscle performance were examined using sequential regression models. Adjusting for age, sex, body mass index, and pain levels, there were significant positive relationships for thickness (p < 0.001, β = 0.718) and viscosity (p = 0.006, β = 0.496) with CMJ height. There were significant negative relationships between CSA with both CMJ height (p = 0.001, β = −0.538) and CAR (p = 0.04, β = −0.517). This is the first study to demonstrate relationships between tendon structure and lower extremity function or quadriceps muscle performance in patients with patellar tendinopathy. Clinical significance: Since structural changes persist after symptom resolution, addressing these changes may assist in restoring lower extremity function and quadriceps muscle performance.
Gremlin aggravates periodontitis via activation of the nuclear factor‐kappa B signaling pathway
Authors: Guan Xiaoyue , He Yani , Li Yingxue , Shi Chen , Wei Zhichen , Zhao Rui , Han Yue , Pan Lifei , Yang Jianmin , Hou Tiezhou 
Published: January 2022

AbstractBackgroundGremlin has been reported to regulate inflammation and osteogenesis. Periodontitis is a destructive disease degenerating periodontal tissues, therefore leads to alveolar bone resorption and tooth loss. Based on the importance of Gremlin's bio‐activity, the aim of this study is to, in vivo and in vitro, unveil the function of Gremlin in regulating the development of periodontitis and its consequent effects on alveolar bone loss.MethodsClinical specimens were used to determine the expression of Gremlin in periodontal tissues by immunohistochemical staining and western blot. Then utilizing the rat periodontitis model to investigate the function of gremlin‐regulated nuclear factor‐kappa B (NF‐κB) pathway during the development of periodontal inflammation and the alveolar bone loss. Last, the regulation of the osteogenesis of human periodontal ligament stem cells (hPDLSCs) by Gremlin under inflamed condition was analyzed by alkaline phosphatase (ALP) and alizarin red staining (ARS).ResultsWe found clinically and experimentally that the expression of Gremlin is markedly increased in periodontitis tissues. Interestingly, we revealed that Gremlin regulated the progress of periodontitis via regulating the activities of NF‐κB pathway and interleukin‐1β (IL‐1β). Notably, we observed that Gremlin influenced the osteogenesis of hPDLSCs. Thus, our present study identified Gremlin as a new key regulator for development of periodontitis.ConclusionsOur current study illustrated that Gremlin acts as a crucial mediator and possibly serves as a potential diagnostic marker for periodontitis. Discovery of new factors involved in the pathophysiology of periodontitis could contribute to the development of novel therapeutic treatment for the disease.
Decision on single‐use and reusable food packaging: searching for the optimal solution using a fuzzy mathematical approach
Authors: Böröcz Péter 
Published: January 2022

AbstractBACKGROUNDIn modern food supply chains it is becoming increasingly important for companies to have sustainable product packaging systems. Deciding the protection, marketing, and logistical function of packaging, at optimal cost, is a very complex matter for professionals. The decision is usually between disposable (single‐use) and reusable (returnable) packaging solutions and their special characteristics. In practice, the focus of this decision is based on historical experience and traditions, taking a cost‐based and/or a criteria‐based approach. This considers a wide range of cost factors. Packaging cost is an important factor, but not the only one, in determining the optimal solution.RESULTSThis study presents a three‐dimensional fuzzy signature model with a fuzzy method that can be applied to the packaging decision problem to investigate the interconnections among factors that affect the final results, beyond simple binary logic. Two types of food packaging, beverage glass and polyethylene terephthalate (PET) bottles, were chosen to validate the usability of the model.CONCLUSIONFuzzy signatures can model the subjectivity of human definitions and criteria using the knowledge of professionals – human knowledge, which is experienced under real conditions and is used in practice in the food‐packaging decision process. Food‐packaging decision components and the final decision can be determined by fuzzy algorithms using membership functions on aggregation and weighted values. © 2022 The Author. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Lessons learned and keys to success: Provider experiences during the implementation of virtual oncology tumor boards in the era of COVID‐19
Authors: Perlmutter Breanna , Said Sayf Al‐deen , Hossain Mir Shanaz , Simon Robert , Joyce Daniel ,  Walsh R. Matthew , Augustin Toms 
Published: January 2022

AbstractBackground and ObjectivesThe COVID‐19 pandemic required rapid adaptation of multidisciplinary tumor board conferences to a virtual setting; however, there are little data describing the benefits and challenges of using such a platform.MethodsAn anonymous quality improvement survey was sent to participants of tumor board meetings at a large academic institution. Participants answered questions pertaining to the relative strengths and weaknesses of in‐person and virtual settings.ResultsA total of 335 responses (23.3% response rate) were recorded, and 253 met inclusion criteria. Respondents represented 25 different tumor board meetings, with colorectal, breast, and liver (18.6%, 17.0%, and 13.0%, respectively) being the most commonly attended. Virtual tumor boards were equivalent to in‐person across 9 of 10 domains queried, while a virtual format was preferred for participation in off‐site tumor boards. The lack of networking opportunities was ranked by physicians to be a significant challenge of the virtual format. Consistent leadership and organization, engaged participation of all attendees, and upgrading technology infrastructure were considered critical for success of virtual meetings.ConclusionsThe implementation of virtual tumor board meetings has been associated with numerous challenges. However, improving several key aspects can improve participant satisfaction and ensure excellent patient care.
Structure and projected decline of a Karoo dwarf tortoise population
Authors: Loehr Victor J. T. , Keswick Toby 
Published: January 2022

AbstractInconspicuous, secretive, or sparsely distributed species receive relatively little research attention, potentially leading to uncertainty about their status and lack of efforts to conserve them. Karoo dwarf tortoises (Chersobius boulengeri) are endemic to South Africa, spend most of the time in retreats at remote arid locations, and are seldom seen. We conducted a 3‐year (2018–2020) mark‐recapture study to investigate the size and structure of the only Karoo dwarf tortoise population currently known to exist. The population in the 16‐ha core of our study site consisted primarily of adult males and females, at a density of 3.3 individuals/ha. Many individuals had severely worn shells and appeared old. Small individuals (straight carapace length <65 mm) represented just 8% of the population and were mostly recent hatchlings. Overall, tortoises had high estimated survival rates (0.77–0.95; lower 95% confidence limit for the smallest tortoises was 0.16), despite a 15‐month drought. The lack of small individuals may reflect low levels of recruitment and population decline. Predation by corvids was an obvious threat to all size classes. We estimated that the local population across the 250‐ha study area was 800–900 males and females, and recommend precautionary conservation measures focused on reducing human‐subsidized avian predation.
Poplar agroforestry systems in eastern China enhance the spatiotemporal stability of soil microbial community structure and metabolism
Authors: Wang Bo , Zhu Ling , Yang Tao , Qian Zhuangzhuang , Xu Cheng , Tian Di , Tang Luozhong 
Published: January 2022

AbstractAgroforestry systems provide soil microorganisms with a rich variety of carbon sources and a relatively stable living environment. However, the effects of agroforestry systems on the metabolic dynamics of soil microorganisms have not been well studied, especially in the subsoil. To assess the vertical and seasonal variations in soil microbial metabolic capacity as a consequence of various planting systems, five typical planting systems, including three poplar agroforestry systems, were investigated. The Biolog EcoPlate method was used to determine the vertical and seasonal variations in soil microbial metabolic capacity. The average well colour development, carbon source utilization ability, and microbial diversity index values were higher throughout the soil profile, and highly stable with seasonal changes in the poplar (Populus × euramericana “Nanlin 895”) + wheat (Triticum aestivum L.) + soybean (Glycine max) and poplar + potherb mustard (Brassica juncea var. multiceps) agroforestry systems. Furthermore, the influence of the planting systems and seasonal changes on the metabolic activity of soil microorganisms decreased with an increase in soil depth. Over‐stocking chickens in the forest reduced the metabolic activity of soil microorganisms. It was also found that plants influenced soil microbial metabolism through affecting the available carbon source types. Therefore, agroforestry systems improved the metabolic potential of the soil microbial community. Our results demonstrated that soil microbial communities are affected by the planting system and soil depth. The findings enhance our understanding of the functional diversity of soil microorganisms in agroforestry systems.
Metabolovigilance: Associating Drug Metabolites with Adverse Drug Reactions
Authors: Tan Henry , Reed Scott M. 
Published: January 2022

AbstractThe Metabolovigilance database (https://pharmacogenomics.clas.ucdenver.edu/pharmacogenomics/side‐effect/) is a single repository of information on over 15,920 pharmaceuticals and the compounds expected to result from metabolism of these drugs. Metabolovigilance functions as both a web server, providing data directly to users and as a web application, applying user inputs to create logic statements that curate the data presented or downloaded. Using this tool, it is easy to collect information on drugs, their side effects, and the metabolites associated with specific side effects. Information on these compounds can be sorted based on physical properties of the drugs and their metabolites. All of this information can be viewed, sorted, and downloaded for use in other applications. This open‐access tool will facilitate molecular studies on the causes of adverse drug reactions and is well suited to integrate with genomic data furthering the goals of personalized medicine.
The senile hand: Age effects on intrinsic hand muscle CMAP amplitudes influence split‐hand index calculations
Authors: Pechirra Gonçalo , Swash Michael , de Carvalho Mamede 
Published: January 2022

AbstractIntroduction/AimsAge can affect hand muscles non‐uniformly. We investigated the influence of age on the compound muscle action potential (CMAP) amplitude of the hand muscles and the derived split‐hand index (SHI).MethodsWe studied 244 subjects investigated for suspected myasthenia gravis but without neuromuscular disorders. Abductor pollicis brevis (APB), first dorsal interosseous (FDI), and abductor digiti minimi (ADM) CMAPs were obtained by supramaximal stimulation at the wrist, recording with surface electrodes while checking the best recording site. We applied Tukey's HSD and Kruskal–Wallis one‐way analysis of variance for comparing age groups defined by median and interquantile ranges (IQRs). Spearman's rank correlation coefficient and linear regression were used for testing age‐dependence of measurements.ResultsMedian age was 61.5 y (first IQR, 44.5; third IQR, 72.0; range 18–89). Age and neurophysiological measurements were similar between genders. APBCMAP, FDICMAP, ADMCMAP, and SHI were correlated with age (P < .001). Median and cutoff values were significantly different between age groups. APBCMAP, FDICMAP, and ADMCMAP decreased by 0.8/0.7/0.3 mV/y, respectively, and SHI decreased 0.15/y.DiscussionThe CMAP amplitudes of hand muscles and derived SHI were strongly age‐dependent, although this effect was less in ADM. This represents a physiological phenomenon. Future studies using the SHI should consider age effects.
Effect of malnutrition on the postoperative outcomes of patients undergoing pancreatectomy for pancreatic cancer: Propensity score–matched analysis of 2011–2017 US hospitals
Authors: Lee David Uihwan , Hastie David Jeffrey , Fan Gregory Hongyuan , Addonizio Elyse Ann , Lee Ki Jung , Han John , Karagozian Raffi 
Published: January 2022

AbstractBackgroundPatients with pancreatic cancer suffer from metabolic dysregulation, which can manifest in clinical malnutrition. Because a portion of these patients require cancer‐resective surgery, we evaluate the impact of malnutrition in patients undergoing pancreatic resection using a national database.MethodsThe 2011–2017 National Inpatient Sample was used to isolate cases of pancreatic resection (partial/total pancreatectomy and radical pancreaticoduodenectomy), which were stratified using malnutrition. A 1:1 nearest‐neighbor propensity‐score matching was applied to match the controls to the malnutrition cohort. End points include mortality, length of stay (LOS), hospitalization costs, and postoperative complications.ResultsFollowing the match, there were 2108 with malnutrition and an equal number without; from this, those with malnutrition had higher mortality (4.7% vs 3.04%; P = 0.007; odds ratio [OR], 1.57; 95% CI, 1.14–2.17), longer LOS, and higher costs. Regarding complications, malnourished patients had higher bleeding (5.41% vs 2.99%; P < 0.001; OR, 1.86; 95% CI, 1.36–2.54), wound complications (3.75% vs 1.57%; P < 0.001; OR, 2.45; 95% CI, 1.62–3.69), infection (7.83% vs 3.13%; P < 0.001; OR, 2.63; 95% CI, 1.96–3.52), and respiratory failure (7.45% vs 3.56%; P < 0.001; OR, 2.18; 95% CI, 1.65–2.89). In multivariate analyses, those with malnutrition had higher mortality (P = 0.008; adjust OR, 1.55; 95% CI, 1.12–2.14).ConclusionThose with malnutrition had higher mortality and complications following pancreatic resection; given these findings, it is important that preoperative nutrition therapy is provided to minimize the surgical risks.
School‐based ADHD services: Perspectives from racially and ethnically minoritized students
Authors: Golson Megan E. , Roanhorse Tyus T. , McClain Maryellen B. , Galliher Renee V. , Domenech Rodríguez Melanie M. 
Published: January 2022

AbstractAttention‐deficit/hyperactivity disorder (ADHD) can impact students' academic, social, and behavioral outcomes. To improve student outcomes, schools regularly identify students with ADHD and develop relevant educational programming. However, the extant research that supports these practices underrepresents racially and ethnically minoritized (REM) students. To address this gap, this study investigates the experiences of REM students (N = 35) receiving school‐based ADHD services. The average participant age was 15.8 years, and the majority of participants were male (57.1%). Results from this phenomenological investigation revealed 5 themes and 14 subthemes describing REM students' thoughts, feelings, and experiences of ADHD assessment, intervention, and parent involvement in these processes. These findings suggest REM adolescent students should be informed decision‐makers in their school‐based services, though they are often left out of the planning process. Additionally, student reports support the involvement of parents and interdisciplinary community professionals in school‐based services.
Analysis of a large prostate cancer family identifies novel and recurrent gene fusion events providing evidence for inherited predisposition
Authors: Raspin Kelsie , O'Malley Dannielle E. , Marthick James R. , Donovan Shaun , Malley Roslyn C. , Banks Annette , Redwig Frank , Skala Marketa , Dickinson Joanne L , FitzGerald Liesel M. 
Published: January 2022

AbstractThere is strong interest in the characterisation of gene fusions and their use to enhance clinical practices in prostate cancer (PrCa). Significantly, ~50% of prostate tumours harbour a gene fusion. Inherited factors are thought to predispose to these events but, to date, only one study has investigated gene fusions in a familial context. Here, we examined the prevalence and diversity of gene fusions in 14 tumours from a single large PrCa family, PcTas9, using the TruSight® RNA Fusion Panel and Sanger sequencing validation. These fusions were then explored in The Cancer Genome Atlas (TCGA) PrCa data set (n = 494). Overall, 64.3% of PcTas9 tumours harboured a gene fusion, including known erythroblast transformation‐specific (ETS) fusions involving ERG and ETV1, and two novel gene fusions, C19orf48:ETV4 and RYBP:FOXP1. Although 3′ ETS genes were overexpressed in PcTas9 and TCGA tumour samples, 3′ fusion of FOXP1 did not appear to alter its expression. In addition, PcTas9 fusion carriers were more likely to have lower‐grade disease than noncarriers (p = 0.02). Likewise, TCGA tumours with high‐grade disease were less likely to harbour fusions (p = 0.03). Our study further implicates an inherited predisposition to PrCa gene fusion events, which are associated with less aggressive tumours. This knowledge could lead to clinical strategies to predict men at risk for fusion‐positive PrCa and, thus, identify patients who are more or less at risk of aggressive disease and/or responsive to particular therapies.
Gas pipeline safety management system based on neural network
Authors: Mujtaba Syed Muhammad , Lemma Tamiru Alemu , Vandrangi Seshu Kumar 
Published: January 2022

AbstractThe risk of leakage poses a grave threat to natural gas pipeline safety. The high compressibility of gases combined with unsteady boundary conditions makes detecting leaks in pipelines a challenging endeavor. To date, in the literature, only a limited number of studies have focused on leak detection and diagnostics in gas mixture pipelines. The present study provides a system for detecting, locating, and estimating the size of small gas leaks from a compressible and dynamic natural gas flow in pipelines with improved accuracy. As a case study, a long natural gas pipeline of 80 km is simulated with leak sizes of 0%, 2%, and 5%. The safety system is developed using mass flow rate, temperature, and pressure measurements. Six classes for faulty cases and one class for no fault case were considered for the study. A shallow neural network classifier (SNNC) is trained to identify a specific fault class. The SNNC is based on a two‐layered network with 20 and 7 neurons. An input vector of 15 variables is provided to the system, and the output is one of the seven possible classes. Leakage as low as 2% at various locations are correctly diagnosed with more than 99% correct classification rate.
Weed pressure determines the chemical profile of wheat (Triticum aestivum L.) and its allelochemicals potential
Authors: Hussain M Iftikhar , Vieites‐Álvarez Yedra , Otero Paz , Prieto Miguel A , Simal‐Gandara Jesus , Reigosa Manuel J , Sánchez‐Moreiras Adela M 
Published: January 2022

AbstractBACKGROUNDCommon purslane (Portulaca oleracea) and annual ryegrass (Lolium rigidum) are important infesting weeds of field crops. Herbicides are mostly used for weed suppression, while their environmental toxicity and resistance in weeds against them demand considering alternative options, such as the use of allelopathic crops for weed management. Wheat is an important allelopathic crop and present research focused on the identification and quantification of benzoxazinoids (BXZs) and polyphenols (phenolic acids and flavonoids) of the wheat accession ‘Ursita’ and to screen its allelopathic impact on P. oleracea and Lolium rigidum through equal‐compartment‐agar (ECA) method.RESULTSWeed germination, radicle length, biomass and photosynthetic pigments were altered following co‐growth of weeds with Ursita for 10‐day. Root exudates from Ursita reduced (29–60%) the seedling growth and photosynthetic pigments of Lolium rigidum depending on co‐culture conditions of planting density. Weed pressure caused significant increase in the production of phenolic acids (vanillic, ferulic, syringic and p‐coumaric acids) and root exudation of BXZs, in particular benzoxazolin‐2‐one (BOA), 2‐hydroxy‐7‐methoxy‐1,4‐benzoxazin‐3‐one (HMBOA), 2‐hydroxy‐1,4‐benzoxazin3‐one (HBOA) and 2,4‐dihydroxy‐1,4‐benzoxazin‐3‐one (DIBOA) in wheat tissues (shoots, roots) and exudate in root rhizosphere agar medium in response to co‐cultivation with Lolium rigidum and P. oleracea, depending on weed/crop density.CONCLUSIONThe work revealed that Ursita is allelopathic in nature and can be used in breeding programs to enhance its allelopathic activity. Meanwhile, there are opportunities to explore allelopathic effect of wheat cultivars to control P. oleracea and Lolium rigidum under field conditions. © 2022 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.