bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Double Deposition and Stripping Steps System for Minimization of Interferences of Peaks’ Overlapping in Anodic Stripping Voltammetry
Authors: Gęca Iwona 
Published: July 2022

AbstractAn anodic stripping voltammetric procedure for the determination of bismuth in the presence of excess of Cu2+ ions at two ex situ plated gold film electrodes was described. The procedure is based on utilization of two deposition and two stripping steps system. The presented procedure ensures increasing the sensitivity of Bi3+ determination and minimization of interferences related to peaks’ overlapping. The calibration graph for bismuth determination was linear from 2.5×10−9 to 2×10−8 mol L−1 for deposition time of 300 s at both working electrodes while detection limit was 7.7×10−10 mol L−1.
Influence of processing conditions on the aroma profile of Litopenaeus vannamei by SPME‐GC‐MS
Authors: Duppeti Haritha , Kempaiah Bettadaiah Bheemanakere , Manjabhatta Sachindra Nakkarike 
Published: July 2022

AbstractThis study reports the aroma profile of Litopenaeus vannamei under different processing conditions such as raw, boiled, hot air dried, microwave dried and roasted using SPME‐GC‐MS. A total of 86 volatile compounds were identified, among which 38 compounds reported as aroma‐active compounds (AAC) having the odour activity value (OAV) greater than one. The microwave‐dried shrimp meat (MSM) exhibited the highest summation of odour activity value, and roasted shrimp meat (RSM) showed the highest concentration of aroma‐active compounds (3448.78 μg/g). The partial least square regression (PLSR) analysis and cluster analysis (CA) showed that MSM and RSM are related to each other in their aroma characteristics while boiled shrimp meat (BSM) is different than these samples. The results of this study illustrate the typical volatile markers and the impact of processing methods on flavour generation in L. vannamei, which should be examined for the assessment of its freshness and product development based on shrimp flavour.
Trades or quotes: Which drives price discovery? Evidence from Chinese index futures markets
Authors: Jin Liwei , Yuan Xianghui , Wang Shihao , Li Peiran , Lian Feng 
Published: July 2022

AbstractIn this paper, we analyze the role that trades and quotes play in price discovery. Based on tick‐level data for CSI 300 stock index futures, we find that the contribution of quotes to price discovery does not differ from trades at low resolutions, but dominates at high resolutions. This difference is influenced by spreads and volume. Further analysis reveals that the intraday price contribution of quotes and trades is trending downward, up to 31% in the first half‐hour. The adverse selection and liquidity supply cost components of spreads significantly contribute to and dampen the difference in intraday contribution, respectively.
Curative high‐dose reirradiation for patients with recurrent head and neck squamous cell carcinoma using IMRT or proton therapy: Outcomes and analysis of patterns of failure
Authors: Beddok Arnaud , Saint‐Martin Caroline , Krhili Samar , Eddine Catherine Ala , Champion Laurence , Chilles Anne , Goudjil Farid , Zefkili Sofia , Amessis Malika , Peurien Dominique , Choussy Olivier , le Tourneau Christophe , Dendale Remi , Buvat Irene , Créhange Gilles , Calugaru Valentin 
Published: July 2022

AbstractPurposeTo analyze outcomes of patients treated with curative reirradiation (reRT), with intensity‐modulated radiation therapy (IMRT) or proton therapy (PT) for recurrent head and neck squamous cell carcinoma (HNSCC).MaterialsAmong the 55 patients reirradiated for head and neck cancer from 30/08/2012 to 08/04/2019, 23 had HNSCC and received IMRT (52.2%) or PT (47.8%) at a median maximum dose to the CTV of 66 Gy.ResultsAfter a median follow‐up of 41.3 months, 18 patients developed a locoregional recurrence (LR), of which eight (44.4%) occurred within the previously reirradiated volume. Two‐year locoregional failure‐free survival and overall survival were 18.3%[95%CI:7.1%–47.1%] and 42.5%[95%CI:26.2%–69.1%], respectively. Disease‐free survival was significantly longer in the PT group (p = 0.031). Main late grade ≥2 toxicities were dysphagia and trismus.ConclusionCurative reRT in HNSCC is possible for selected cases, but the LR rate in the irradiated field and the risk of toxicity grade ≥2 remain high.
A systematic review and meta‐analysis of abnormalities in hematological and biochemical markers among Bangladeshi COVID‐19 cases
Authors: Bhowmik Khokon Kanti , Barek Md. Abdul , Aziz Md. Abdul , Islam Mohammad Safiqul 
Published: July 2022

AbstractBackground and AimsAbnormalities in hematological and biochemical markers are assumed to be associated with the progression of COVID‐19 disease. This meta‐analysis was performed to assess the consequences of abnormalities of biomarkers (D‐dimers, C‐reactive protein [CRP], serum ferritin, lactate dehydrogenase [LDH], random blood sugar [RBS], absolute neutrophil count [ANC], neutrophil to lymphocyte ratio (NLR), serum creatinine, and hemoglobin) in the Bangladeshi COVID‐19 patients.MethodsThe data of biomarker levels in Bangladeshi COVID‐19 patients were gathered from five databases: PubMed, ScienceDirect, Web of Science, Google Scholar and Bangladesh Journals Online between January 2020 to March 2022. Review Manager 5.4 was used for the meta‐analysis, and Egger's test and Begg‐Mazumdar's rank correlation were used to investigate publication bias.ResultsThis study included 1542 patients with 567 severe and 975 nonsevere statuses. Based on the accumulated data synthesis, there is a strong correlation between disease severity and different biomarkers, including D‐dimer, CRP, ferritin, LDH, RBS, NLR, and serum creatinine (MD = 1.16, p = 0.0004; MD = 22.97, p = 0.003; MD = 419.26, p < 0.00001; MD = 118.37, p = 0.004; MD = 1.96, p = 0.02; MD = 1.26, p = 0.02; and MD = 0.31, p = 0.008, respectively). A significantly decreased correlation was observed for hemoglobin levels in severe COVID‐19 patients (MD = −0.73, p = 0.10).ConclusionThe elevated biomarkers level was noticed in severe cases compared to nonsevere patients, revealing that D‐dimer, CRP, ferritin, LDH, RBS, NLR, and serum creatinine are significantly correlated to COVID‐19 severity. Only lower hemoglobin level was found to be associated with COVID‐19 severity.
Serological findings following the second and third SARS‐CoV‐2 vaccines in lung transplant recipients
Authors: Bárczi Enikő , Varga Viktória , Nagy Alexandra , Eszes Noémi , Jáky‐Kováts Zsuzsanna , Müller Veronika , Bohács Anikó 
Published: July 2022

AbstractIntroductionLung transplant recipients (LuTX) represent a vulnerable population for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Even though many vaccines are already developed, more clinical data need to support effective immunological response in immunocompromised patients.MethodsStable LuTX recipients with no medical history of coronavirus disease (COVID‐19) were enrolled. Currently available messenger RNA (mRNA) (BNT162b2‐mRNA, mRNA‐1273) and non‐mRNA (ChAdOx1, BBIBP‐CorV) vaccines were given according to availability, boosters were all mRNA‐based. SARS‐CoV‐2 Spike1 immunoglobulin G (IgG) antibody titer was evaluated before and 2 weeks after second and third dose. Difference between mRNA versus non‐mRNA vaccines was assessed.RESULTSForty‐one patients (49% men, age 48.4 ± 13.8 years) received two doses of SARS‐CoV‐2 vaccines: 23 of mRNA, 18 of non‐mRNA, and 24/41 (58%) received a third dose. Median 92 months passed since transplantation, and serum level of tacrolimus was median 5.5 ng/ml. Positive serology was found in 37% of all patients after the second dose, 86% had mRNA vaccine. After the third dose, 29% became positive who had no antibody before. Significantly higher level of antibody was found after the second mRNA than non‐mRNA vaccines (2.2 vs. 1568.8 U/ml, respectively, p = .002). 6/23 (26%) patients received two doses of mRNA vaccine developed COVID‐19 after the second injection in an average of 178 days, half of them recovered, half of them died in intensive care unit (ICU). 3/6 (50%) patients with two doses mRNA and recovered from COVID‐19 had significantly higher level of antibody (average 20847.3 U/ml) than without infection. After the booster vaccine, 1/24 (4%) developed infection.ConclusionImmunosuppression therapy may induce a weaker SARS‐CoV‐2 response in LuTX recipients; therefore, third dose is a priority in transplanted patients. The highest antibody level was measured recovering from COVID after two doses. Our data confirm that booster mRNA vaccine could increase antibody levels, even if immunization was started with non‐mRNA vaccine.
Enhancing level set brain tumor segmentation using fuzzy shape prior information and deep learning
Authors: Khosravanian Asieh , Rahmanimanesh Mohammad , Keshavarzi Parviz , Mozaffari Saeed 
Published: July 2022

AbstractMagnetic resonance imaging (MRI) brain tumor segmentation is a crucial task for clinical treatment. However, it is challenging owing to variations in type, size, and location of tumors. In addition, anatomical variation in individuals, intensity non‐uniformity, and noises adversely affect brain tumor segmentation. To address these challenges, an automatic region‐based brain tumor segmentation approach is presented in this paper which combines fuzzy shape prior term and deep learning. We define a new energy function in which an Adaptively Regularized Kernel‐Based Fuzzy C‐Means (ARKFCM) Clustering algorithm is utilized for inferring the shape of the tumor to be embedded into the level set method. In this way, some shortcomings of traditional level set methods such as contour leakage and shrinkage have been eliminated. Moreover, a fully automated method is achieved by using U‐Net to obtain the initial contour, reducing sensitivity to initial contour selection. The proposed method is validated on the BraTS 2017 benchmark dataset for brain tumor segmentation. Average values of Dice, Jaccard, Sensitivity and specificity are 0.93 ± 0.03, 0.86 ± 0.06, 0.95 ± 0.04, and 0.99 ± 0.003, respectively. Experimental results indicate that the proposed method outperforms the other state‐of‐the‐art methods in brain tumor segmentation.
Exploring the effects of family control on dividend policy—Evidence from Canada
Authors: Leung Raymond 
Published: July 2022

AbstractThis study examines if publicly listed family‐controlled corporations (hereafter called FCCs) have more differential effects on cash dividend policy (in both willingness to pay and amounts paid) than non‐FCCs. While the literature provides mixed conclusions, this study focuses on the theoretical underpinning that FCCs’ unique behavior model with objective to preserve their socio‐emotional wealth (SEW) tend to protect their highly undiversified invested capital, operate conservatively and conserve corporate wealth for future generations. As a result, FCCs, especially those with large size and large accumulated profits, would pursue type II expropriative agency motive by lowering cash dividend payout. Nevertheless, when FCCs operate for long years, their transgenerational sustainability intentions and reputational concerns stemmed from the SEW will induce FCCs to endeavor non‐financial goals. This study further finds evidence that FCCs with longer years, and accumulated large retained earnings and size are willing to align with minority shareholders’ interests by being more willing to pay more cash dividends. However, comparing to their non‐FCC counterparts, the heterogeneous variable of FCCs age interacts with retained earnings and size to cause larger positive effects in willingness to pay more cash dividends; and cash dividend payouts.
Pediatric Invasive Fungal Rhinosinusitis: A Comprehensive Analysis of Prognostic Factors for Survival
Authors: Patel Vijay A. , LePhong Christopher D. , Osterbauer Beth , Gomez Gabriel , Don Debra M. , Ference Elisabeth H. , Hochstim Christian J. , Koempel Jeffery A. 
Published: July 2022

ObjectivePediatric invasive fungal rhinosinusitis (IFS) is a devastating infection that manifests almost exclusively in immunocompromised children. The goal of this work was to determine which clinical features carry prognostic value for survival.MethodsA retrospective review of children with a histopathological diagnosis of IFS was performed at an academic tertiary care institution from 1990 to 2021. Clinical variables were collected to generate survival and life‐table estimators at 6‐months and 1‐year.ResultsEighteen patients were included in this analysis, with a mean age of 9.8 years (range, 1–17 years). Most children were neutropenic (n = 15, 83.3%), with acute lymphoblastic leukemia (n = 10, 55.6%) representing the most common primary diagnosis. A mean of 3.2 operations (range 1–7 operations) was performed per patient for either mucormycosis (n = 10, 55.6%) or aspergillosis (n = 8, 44.4%). The mean time to absolute neutrophil count recovery was 65.8 days (range 20–137 days), with a 6‐month and 1‐year survival rate of 47.6% and 41.7%, respectively. Gross total resection (p = 0.006, p < 0.001), number of antifungals (p = 0.0004, p = 0.0003), and total operation number (p = 0.0032, p = 0.0035), served as positive prognostic factors for 6‐month and 1‐year survival. Conversely, altered mental status (p = 0.0026), cerebral involvement (p = 0.0010), cranial neuropathies (p < 0.0001), hyperglycemia (p = 0.0445, p = 0.0208), and intensive care unit status (p = 0.0013) served as negative prognostic factors for 6‐month and 1‐year survival.ConclusionSeveral key elements were identified and found to play a vital role in influencing survival for pediatric IFS. Early diagnosis, prompt medical therapy, and aggressive surgical intervention remain at the forefront in the treatment of this complex opportunistic infection.Level of Evidence4 Laryngoscope, 133:1239–1250, 2023
Development of a Self‐Adhesive Oleogel Formulation Designed for the Slow Release of Semiochemicals
Authors: Muskat Linda C. , Jiang Lin , Brikmann Johannes , Rostás Michael , Patel Anant V. 
Published: July 2022

AbstractOleogels have been widely studied as delivery matrices for lipophilic compounds. Despite their potential, oleogels are underexplored for the formulation and release of semiochemicals for insect behavior manipulation strategies. An ethylcellulose‐candelilla wax‐oleogel as a suitable carrier for the slow release of volatile semiochemicals, employing the sesquiterpene β‐caryophyllene as a model substance is presented. A current drawback of ethylcellulose oleogels is the high temperature needed during the oleogel preparation procedure, leading to excessive volatilization of the active compounds. Reducing the gelling temperature from 104.8 to 66.9 °C and, thus, the volatile addition temperature by addition of the softener octyldodecanol results in 95.28% entrapment efficiency. Experimental results demonstrate release modifiability by tailoring the matrix crystalline state due to candelilla wax addition. Furthermore, a method is established for analyzing the self‐adhesive properties of the gel on plant leaves. In addition, the gel's self‐adhesive properties employed on apple leaves are synergistically affected by oil leakage and gel stiffness. Olfactometer experiments showed that the formulation is able to enhance the attractiveness of aphid‐infested plants for parasitic wasps. The present study provides a novel matrix‐type semiochemical formulation based on non‐toxic, biobased and biodegradable materials and will contribute to the establishment of oleogels as delivery systems for semiochemicals.
Outbreak control management: Lessons from SARS‐CoV‐2 infections in 2020–2022 in Hong Kong, an international municipality with high‐frequency travelers
Authors: Feng Yaxiu , Young Ching Han , Lau Siu Hin , He Ming‐Liang 
Published: July 2022

AbstractThe control management of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infections is one of the most challenges in the 21st century. By May 8th, 2022, SARS‐CoV‐2 has infected over 510 million people with 6.2 million death worldwide and over 1.2 million people with 9133 deaths in the fifth wave of infection in Hong Kong. The government responded rapidly in the early days of the 2020 outbreak, and the results were encouraging to control COVID‐19 outbreak unavailable of vaccine. The quick responses to the epidemic alerts, for example, public education and control policies, kept residents safe from infection in the city with such a high population density and large‐scale travelers. Nevertheless, the extremely high infectivity, Omicron variant infections, and the shortcomings of transmission control measures led to uncontrollable outbreak in 2022. The weak immunity groups, elderly and children, experienced a high hospitalization rate and mortality rate because of low vaccination rate. Currently, the infection is under well controlled. This study timely summarizes the challenges, policy, and lessons of SARS‐CoV‐2 outbreak control from 2020 to 2022. More importantly, the lesson and policy revealed from this study may be beneficial and applied to other cities with the outbreak of highly infectious SARS‐CoV‐2.
Mutation spectrum in a cohort with familial exudative vitreoretinopathy
Authors: Qu Ning , Li Wei , Han Dong‐Ming , Gao Jia‐Yu , Yang Zheng‐Tao , Jiang Li , Liu Tian‐Bin , Chen Yan‐Xian , Jiang Xiao‐Sen , Zhou Liang , Wu Ji‐Hong , Huang Xin 
Published: July 2022

AbstractPurposeTo expand the mutation spectrum of patients with familial exudative vitreoretinopathy (FEVR) disease.Participants74 probands (53 families and 21 sporadic probands) with familial exudative vitreoretinopathy (FEVR) disease and their available family members (n = 188) were recruited for sequencing.MethodsPanel‐based targeted screening was performed on all subjects. Before sanger sequencing, variants of LRP5, NDP, FZD4, TSPAN12, ZNF408, KIF11, RCBTB1, JAG1, and CTNNA1 genes were verified by a series of bioinformatics tools and genotype–phenotype co‐segregation analysis.Results40.54% (30/74) of the probands were sighted to possess at least one etiological mutation of the nine FEVR‐causative genes. The etiological mutation detection rate was 37.74% (20/53) in family‐attainable probands while 47.62% (10/21) in sporadic cases. The diagnosis rate of patients in the early‐onset subgroup (≤5 years old, 45.4%) is higher than that of the children or adolescence‐onset subgroup (6–16 years old, 42.1%) and the late‐onset subgroup (≥17 years old, 39.4%). A total of 36 etiological mutations were identified in this study, comprising 26 novel mutations and 10 reported mutations. LRP5 was the most prevalent mutant gene among the 36 mutation types with a percentage of 41.67% (15/36). Followed by FZD4 (10/36, 27.78%), TSPAN12 (5/36, 13.89%), NDP (4/36, 11.11%), KIF11 (1/36, 2.78%), and RCBTB1 (1/36, 2.78%). Among these mutations, 63.89% (23/36) were missense mutations, 25.00% (9/36) were frameshift mutations, 5.56% (2/36) were splicing mutations, 5.56% (2/36) were nonsense mutations. Moreover, the clinical pathogenicity of these variants was defined according to American College of Medical Genetics (ACMG) and genomics guidelines: 41.67% (15/36) were likely pathogenic variants, 27.78% (10/36) pathogenic variants, 30.55% (11/36) variants of uncertain significance. No etiological mutations discovered in the ZNF408, JAG1, and CTNNA1 genes in this FEVR cohort.ConclusionsWe systematically screened nine FEVR disease‐associated genes in a cohort of 74 Chinese probands with FEVR disease. With a detection rate of 40.54%, 36 etiological mutations of six genes were authenticated in 30 probands, including 26 novel mutations and 10 reported mutations. The most prevalent mutated gene is LRP5, followed by FZD4, TSPAN12, NDP, KIF11, and RCBTB1. In total, a de novo mutation was confirmed. Our study significantly clarified the mutation spectrum of variants bounded up to FEVR disease.
The profunda artery perforator flap for upper limb reconstruction: A case report and literature review on the flap applications in reconstruction
Authors: Boriani Filippo , Sassu Paolo , Atzeni Matteo , Buckley Christina , Figus Andrea 
Published: July 2022

AbstractThe profunda femoris artery perforator (PAP) flap has been recently popularized as an alternative option for microsurgical reconstruction. The use of PAP flap has never been reported and described for reconstruction of the upper extremities, in particular the forearm. The purpose of this case report is to describe a case suggesting the PAP flap as a further reconstructive option in the upper limb. A 16‐year‐old girl who sustained a traumatic injury to her right dominant forearm resulting in subtotal circumferential tissue loss following a road traffic accident was referred to the authors' department 2 years post‐trauma. The disabling fibrotic sequelae on her volar forearm (15 × 10 cm) resulted in a nonfunctional hand. She was unable to perform any active movement of her wrist or digits. Passive movements in the finger joints were preserved. Following debridement and reconstruction of nerves and tendons, soft tissues were resurfaced with a PAP flap. The transverse skin paddle, 12 × 7 cm, was placed distally with the adipofascial portion positioned proximally above the muscle bellies and anastomoses site. A small raw area (4 × 3 cm) was covered with an acellular dermal matrix (ADM). The postoperative course was uneventful. At 9 months postoperatively, the patient demonstrated active flexion and extension of the fingers with independent function. The patient reported satisfaction with the flap donor site and forearm resurfacing. The PAP flap can be a further option for areas requiring soft tissue coverage in patients refusing visible scars. This flap had both the advantage of reducing the morbidity and visibility of the donor site, as well as the ability to resurface a large recipient site with soft and pliable tissue, covering exposed nerves and tendons.
Effect of Xuanwei Ham Proteins with Different Ripening Periods on Lipid Metabolism, Oxidative Stress, and Gut Microbiota in Mice
Authors: Guo Jie , Xu Feiran , Xie Yong , Chen Bo , Wang Ying , Nie Wen , Zhou Kai , Zhou Hui , Xu Baocai 
Published: July 2022

ScopeConsumption of dry‐cured ham may have a cardiovascular disease preventive capacity. However, whether ham protein in the maintenance of health and prevention of disease is dependent on ripening periods need to be clarified.Methods and resultsFifty C57BL/6 mice consume a diet that contains either Casein, raw ham protein (XWH0), or Xuanwei ham protein after 1‐, 2‐, or 3‐years of maturation (XWH1, XWH2, or XWH3) for 4 weeks. Results show that longer ripening periods in the Xuanwei ham groups are negatively correlated with body weight gain, adipose tissue weight, total cholesterol (TC), and triglycerides levels in serum and liver, and these proteins intake could maintain liver health, reduce lipid deposition and oxidative stress, regulate lipid metabolism‐related genes expression, alter the gut microbiota, and promote short‐chain fatty acid production. Remarkably, XWH3 intake maintains lower TC and low‐density lipoprotein cholesterol levels in serum and has high antioxidative activity as well. This regulation of lipid metabolism and oxidative stress may be related to the AMPK/Nrf2 signaling.ConclusionXuanwei ham dietary proteins that have endured a specific ripening period may have preventive effects on metabolic syndrome, which provide a basis for new ideas for nutritional health interventions.