bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute cardiac side effects after COVID-19 mRNA vaccination, a case series
Authors: Freise Noemi F. , Kivel Milena , Grebe Olaf , Meyer Christian , Wafaisade Bahram , Peiper Matthias , Zeus Tobias , Schmidt Jan , Neuwahl Judith , Jazmati Danny , Luedde Tom , Bölke Edwin , Feldt Torsten , Jensen Björn Erik Ole , Bode Johannes , Keitel Verena , Haussmann Jan , Tamaskovics Balint , Budach Wilfried , Fischer Johannes C. , Knoefel Wolfram Trudo , Schneider Marion , Gerber Peter Arne , Pedoto Alessia , Häussinger Dieter , Griensven Martijn , Rezazadeh Amir , Flaig Yechan , Kirchner Julian , Antoch Gerald , Schelzig Hubert , Matuschek Christiane 
Published: February 2022

Abstract
Background: Since development and approval of the world´s first mRNA vaccines, created under pressure of the global pandemic caused by SARS-CoV-2, potential side effects have naturally been a much-debated topic. Vaccination may be one, if not the only way out of the pandemic claiming more than 4 million deaths worldwide to date. Potential side effects from vaccination have long been controversial, and case reports of fatal side effects have been published. Therefore, data are needed to identify persons being at high risk for potential side effects. Until September 30, 2021, 1.243 cases of myocarditis after vaccination with BNT162b2 Comirnaty© in young adults were registered by the Paul-Ehrlich-Institute in Germany alone. The exact pathophysiology and the risk factors for myocarditis following vaccination remain unclear. We present a case series of eight patients with cardiac symptom shortly after SARS-CoV-2 mRNA vaccination (BNT162b6, Biontech, Comirnaty© or mRNA-1237 Moderna, Spikevax©).Patients and Methods: Eight patients between 13-56 years of age, vaccinated with mRNA vaccine either BNT162b2 or mRNA-1273 between January and August 2021 developed cardiac side effects shortly after either their first or second vaccination. Clinical data were retrieved from the clinical information system and analyzed. To support diagnosis of myocarditis or pericarditis, cardiac magnetic resonance imaging (MRI) was performed shortly after onset of symptoms and investigated further in severe cases. Symptoms were defined as dyspnea, chest pain, cardiac arrhythmia as determined by electrocardiography.Results: Eight patients (five males and three females) developed cardiac symptoms compatible with myocarditis according to CDC criteria shortly after SARS-CoV-2 mRNA vaccination. Three patients (two males, one female) required hospitalization due to severe chest pain and elevated troponin levels. All patients recovered fully within seven days after symptom onsetConclusion: Our data suggest that cardiac adverse events such as myocarditis or pericarditis shortly after SARS-CoV-2 mRNA vaccination are rare but possible and occur particularly in male patients.
Multiscale stochastic volatility for variance swaps with constant elasticity of variance
Authors: Yu Ji-Su , Kim Jeong-Hoon 
Published: February 2022

Abstract
Variance swap is one of volatility derivatives popularly used for the risk management of financial instruments traded in volatile market. An appropriate choice of a volatility model should be an important part of the risk management. In this paper, we consider a hybrid model of constant elasticity of variance and multiscale (fast and slow) stochastic volatility. Based on this framework, we obtain a closed form solution formula for the approximate fair strike values of continuous time variance swaps and compute the solution. The theoretical formula is validated by numerical solution given by MonteCarlo simulation. The multiscale effect and the predictability of the strike price movements are investigated for a given information about the underlying asset and volatility.
The Role Of Collaborative Learning In Resilience In Healthcare - A Thematic Qualitative Meta-Synthesis Of Resilience Narratives
Authors: Haraldseid-Driftland Cecilie , Billett Stephen , Guise Veslemøy , Schibevaag Lene , Alsvik Janne Gro , Fagerdal Birte , Lyng Hilda Bø , Wiig Siri 
Published: February 2022

Abstract
Background: To provide high quality services in increasingly complex, constantly changing circumstances, healthcare organizations worldwide need a high level of resilience, to adapt and respond to challenges and changes at all system levels. For healthcare organizations to strengthen their resilience, a significant level of continuous learning is required. Given the interdependence required amongst healthcare professionals and stakeholders when providing healthcare this learning needs to be collaborative, as a prerequisite to operationalize resilience in healthcare. As particular elements of collaborative working, and learning are likely to promote resilience there is a need to explore the underlying collaborative learning mechanisms and how and why collaborations occur during adaptations and responses. The aim of this study is to describe collaborative learning processes in relation to resilient healthcare based on an investigation of narratives developed from studies representing diverse healthcare contexts and levels.Methods: The method used to develop understanding of collaborative learning across diverse healthcare contexts and levels was to first conduct a narrative inquiry of a comprehensive dataset of published health services research studies. This resulted in 14 narratives (70 pages), synthesised from a total of 40 published articles and 6 PhD synopses. The narratives where then analysed using a thematic meta-synthesis approach.Results: The results show that, across levels and contexts, healthcare professionals collaborate to respond and adapt to change, maintain processes and functions, and improve quality and safety. This collaboration comprises activities and interactions such as exchanging information, coordinating, negotiating, and aligning needs and developing buffers. The learning activities embedded in these collaborations are both activities of daily work, such as discussions, prioritizing and delegation of tasks, and intentional educational activities such as seminars or simulation activities.Conclusions: Based on these findings we propose that the enactment of resilience in healthcare is dependent on these collaborations and learning processes, across different levels and contexts. A systems perspective of resilience demands collaboration and learning within and across all system levels. Creating space for reflection and awareness through activities of everyday work, could support individual, team and organizational learning.
Modeling ARC less InGaP/GaAs Double Junction Solar cell with Tunneling Junction and BSF layer
Authors: azimi nemat , ghari sara , Yoosefi oraman 
Published: February 2022

Abstract
The present study addresses the structure of InGaP/GaAs dual-junction (DJ) solar cells by introducing new buffer and back surface field (BSF) layers as well as selecting the appropriate materials for the tunnel junction. Different performance parameters including open-circuit voltage (𝑉oc) short-circuit current density (𝐽𝑆𝐶), fill factor (𝐹𝐹), and solar cell efficiency (𝜂) were proposed and extracted for comparison with literature results. Then, I-V characteristic curves for the model were represented in graphs. The mentioned parameters, i.e. open-circuit voltage 𝑉𝑂𝐶, short-circuit current density 𝐽𝑆𝐶, fill factor 𝐹𝐹, and solar cell efficiency 𝜂 were, respectively, obtained as 18.50 𝑚𝐴/𝑐𝑚2, 2.862 V, 87/32 percent and 46.23 percent (1sun) under AM1.5G spectrum, which indicates the improvements achieved in this study.
Outcomes After Fertility-sparing Surgery of Early-stage Ovarian Cancer: a Nationwide Population-based Study
Authors: Lee Chia-Yi , Chiang Chun-Ju , Tai Yi-Jou , Hsu Heng-Cheng , Chen Yu-Li , Chiang Ying-Cheng , Wu Chia-Ying , Lee Wen-Chung , Hwa Hsiao-Lin , Cheng Wen-Fang 
Published: February 2022

Abstract
Here we investigated the outcomes of early-stage epithelial ovarian cancer (EOC) following fertility-sparing surgery (FSS)or radical comprehensive staging surgery (RCS), as well as the suitability of FSS.Our analysis included 1297 early-stage EOC cases in the Taiwan Cancer Registry (TCR) database, which were newly-diagnosed between 2009–2017. Based on site-specific surgery codes, patients were divided into two groups:FSS (401 patients) and RCS (896 patients). Cancer-specific survival (CSS) was evaluated using the Kaplan–Meier method with log-rank testing and Cox models. Compared to the FSS group, patients in the RCS group were older (p < 0.001) and more commonly received adjuvant chemotherapy (p<0.001). Independent poor prognostic factors for CSS includedstage (p<0.001)and histologic grade (p< 0.001), but not histologic type (p= 0.13).CSS was similar between women who underwent FSS and those who underwent RCS (p=0.75).FSS group did not show significantly poorer CSS compared with RCS group in serous, mucinous, or endometrioid histologic type. Whereas, among clear cell carcinoma, FSS group had better CSS (HR: 0.28, 95% CI: 0.06–0.82, p=0.040) than RCS group. Endometrioid ovarian cancer patients had the highest frequency of developing second malignancies.FSS canbe a safe alternative procedure in selected young women with early-stage EOC who wish to preserve fertility regardless histologic type. Patients who receive FSS must undergo regular surveillance to detect disease recurrence and second malignancies.
Collagen-induced Arthritis Osteoporosis model and dynamic changes of osteoimmunology
Authors: Mao Wen , Du Yueguang , Shou Zhiqiang , Jin Lu , Li Yuanyuan , Cai Yueqing , Liu Xia , Du Wen xi , Fu Huiying , Shou Qiyang 
Published: February 2022

Abstract
Objective: This present study aimed to establish collagen-induced arthritis (CIA) osteoporosis mice model and dynamically observe the pathological and immune characteristics of CIA osteoporosis mice. Methods: Bovine collagen type was chosen to build the CIA model. The corresponding indexes were observed at 6w, 10w, 14w and 18w after successful modelling: Arthritis Index were used to evaluate RA. The structure and pathological changes of bone and joint were observed by pathological section. X ray film was used to observe morphology of bone and joint; And the serum IL-17 and osteoprotegerin (OPG) levels were detected by Elisa. Rt-PCR was used to assess the mRNA levels of IL-17, NFAT, ROR-γt and Foxp3 in spleen, the mRNA levels of OPG and RANK in bone tissue. Results: In the model group at 6w after modelling, AI and pedal swelling volume began to be increased gradually. Compared with the normal group, the serum IL-17 level in the model group increased gradually with time, the serum OPG level was considerably decreased, the mRNA levels of IL-17, NFAT, ROR- γt, etc. in spleen tissue increased. However, the level of Foxp3 mRNA in the spleen of model group reduced. The expression of OPG mRNA in bone tissues was dropped. RANK mRNA expression was increased. Bone density of both femur and tibia were decreased gradually with time, leading to osteoporosis. X-ray transmittance of the spine increased with time, and the spine presented water-wavy changes at 14w. Conclusion: RA mice model successfully induced by bovine collagen type Ⅱ, and the extension of lesions aggravated over time; Th17 cells results RANKL / OPG and Treg / TH17 imbalance by excessive secreting IL-17, leading to activation of osteoclasts and inhibit the expression of OPG. Therefore, it was involved in the occurrence of osteoporosis in RA in mice.
Vehicle routing problem with cross-docking in a sustainable supply chain for perishable products
Authors: Shahrabi Fatemeh , Nasiri Mohammad Mahdi , Al-e-Hashem S. Mohammad J. Mirzapour 
Published: February 2022

Abstract
Today's transportation, which is primarily based on the combustion of fossil fuels, contributes significantly to energy-related GHG emissions which is one of aspects of sustainability. Incorporating sustainable concerns in cross-dock scheduling can affect decision making for logistics systems. In the current contribution, a sustainable vehicle routing problem with cross-docking is presented. In addition to the economic considerations, this paper addresses the environmental impacts of CO2 emissions and the social impacts, including equity between drivers as well as customer satisfaction. A metaheuristic, composed of GA and mixed integer programming, is proposed as the solution approach. For validating the presented method, instances of various sizes are solved. The results of the GA in small-sized instances, has a small deviation from the optimal fitness values. Finally, a real case study is provided to demonstrate the applicability of the model in a real-world environment, and several in-depth analyses are conducted to infer managerial implications.
Effects of Initial Particle Sizes of Triarrhena Lutarioriparia on Processing Performance, Material Properties, and Heavy Metal Speciation in Sewage Sludge Composting
Authors: Ruan Min , Wu Xikai , Sun Yutong , Huang Zhongliang , Li Hui , Hu Zhangmao , Wu Zijian , Zhang Xuan , Qin Xiaoli , Zhang Yanru , Huang Jing 
Published: February 2022

Abstract
The purpose of this study was to investigate the effect of initial particle size (IPS) on the environmental parameters and heavy metal speciation during sludge composting. Three piles were conducted: fine material (FM, screen underflow), coarse material (CM, oversize product), and mixed material (MM, mix FM and CM in 1:1). Results showed that the temperature trends of the three piles in different layers were highly repeatable during the thermophilic period. With the decrease of IPS, the heating rate and the highest temperature of the pile increased, the thermophilic period was prolonged, and the highest temperature area in the pile shifted to a lower layer. It also promoted the organic matter degradation, compost maturation, and nitrogen fixation effect. Composting had a good effect on the passivation of heavy metals, especially Cd, Cu and Pb. The passivation effect on Cd and Cu was: FM > CM > MM, and on Pb was: CM > FM > MM. Fourier transform infrared spectroscopy, excitation-emission matrix, and thermogravimetric thermal analysis indicated that FM had the highest content of aromatic structure and humic-like substance on D40. The redundancy analysis revealed that MM was beneficial to improve the internal uniformity during composting.
Efficacy of regorafenib combined with PD-1 inhibitors in elderly patients with advanced metastatic colorectal cancer
Authors: Chen Xiaobing , Chen Beibei , Zhao Huichen , Huang Jinxi , Lv Huifang , Xu Weifeng , Nie Caiyun , Wang Jianzheng , Zhao Jing , He Yunduan , Wang Saiqi 
Published: February 2022

Abstract
Objective: This is the first trial that wants to investigate the treatment patterns, clinical outcomes and prognostic factors of regorafenib plus PD-1 inhibitors therapy to Chinese elderly patients with advanced colorectal cancer.Methods: A cohort of metastatic colorectal cancer patients with 60 years or older received treatment of regorafenib combined with PD-1 inhibitors was included in our analysis. The endpoints included overall survival (OS), progression free survival (PFS), and prognostic factors.Results: In total, 24 patients were enrolled. The median age was 68 years; 62.5% were female. The median OS and PFS were 15.03 months (95% CI 7.0-23.0) and 4.0 months (95% CI 1.8-6.2), respectively. The objective response rate was 8.3% and disease control rate was 70.8%. When compared with PFS and OS in different initial daily doses group of regorafenib (such as 40, 80, 120 or 160 mg), we concluded that there were no significantly difference between these groups. And similar results were found in final daily doses groups. However, in terms of final daily doses, it showed a trend toward better PFS in > 80mg group compared to ≤80 mg group (median PFS was 10.0 months in >80mg group versus 3.5 months in ≤80mg group) . Patients with previous treated with regorafenib had longer median PFS than those without it (6.3 versus 2.8 months).Conclusions: This real-world evidence confirms that Chinese elderly patients with advanced colorectal cancer may benefit from treatment of regorafenib combined with PD-1 inhibitors, similarly with this combination therapy strategies in all age patients.
Attitudes and Stigma Toward Seeking Psychological Help Among Saudi Adults
Authors: Alluhaibi Bushra A. , Awadalla Abdel W. 
Published: February 2022

Abstract
Background In the Kingdom of Saudi Arabia (KSA), public attitudes and stigma toward mental health illness seem to prevent people from seeking psychological help, which results in having a negative impact on an individual's life. The primary objective of this study was to investigate people's attitude toward seeking psychological help and identify the extent to which the associated stigma is responsible for preventing them from seeking psychological help. Methods Two hundred and eighteen adults recruited from the community living in the Eastern Province of KSA completed the questionnaires, customized to create the Arabic version of Attitudes Toward Seeking Professional Psychological Help Scale-Short Form (ATSPPH-SF-A), the Arabic version of Stigma Scale for Receiving Psychological Help (SSRPH-A), and the Arabic version of Hopkins Symptom Checklist-25 (HSCL-25-A). Results Both stigma and psychological distress significantly affected attitudes toward seeking professional help. Further, it indicated that attitudes were negatively correlated with stigma while positively correlated with psychological distress. No significant difference in attitudes toward psychological help-seeking was identified between male and female participants. However, males displayed higher levels of stigma, while females showed greater psychological distress. Furthermore, the groups who received psychological treatment demonstrated more favorable attitudes toward seeking psychological help. ConclusionStigma and psychological stress influence the attitudes toward treatment-seeking behavior for mental illness, making them two major predictors responsible for the underutilization of mental health services. More research is needed to assess specific sociodemographic disparities across more data sources and the factors that further contribute to the stigma and psychological distress.
Early Impairment of Right Ventricular Systolic Function in Patients with Prediabetes and Type 2 Diabetes Mellitus: An Analysis of Two-dimensional Speckle Tracking Echocardiography
Authors: Wu Ting , Li Xia , Zhang Dan , gong liang-geng 
Published: February 2022

Abstract
Diabetes mellitus is a risk factor for adverse cardiovascular events, and it can raise the risk of heart failure. The right ventricle makes an important contribution to overall cardiac function, and right ventricular(RV) dysfunction will affect the course and outcome of the disease, therefore, early identification of right ventricular myocardial systolic dysfunction is of great clinical importance. We sought to apply two-dimensional speckle-tracking echocardiography (2D-STE) techniques to determine whether right ventricular global longitudinal strain (RVGLS) and right ventricular free wall strain (RV-FWLS) are altered in patients with prediabetes and diabetes mellitus.This cross-sectional study included 43 patients with prediabetes,52 patients with type 2 diabetes mellitus(T2DM), and 49 age- and sex-matched healthy volunteers were included as controls. Conventional echocardiography measured tricuspid annular systolic excursion (TAPSE), tricuspid valve systolic velocity (RV-S'), and right ventricular fractional change (RV-FAC), and 2D-STE measured left ventricular longitudinal strain (LVGLS), RVGLS, and RV-FWLS. The results showed that TAPSE was not significantly different between the prediabetes group and the control and diabetic groups and RV-S' velocity was not significantly different among the three groups. RV-FAC showed no statistically significant difference between the prediabetes and diabetic groups, RVGLS were significantly impaired and significantly different in the three groups (P=0.000).RVGLS modestly correlated with glycosylated hemoglobin A1c(HbA1c)(r=﹣0.576,P=0.000), and weakly with RVFAC(r=0.398,P=0.000), LVGLS(r=0.416,P=0.000), sex(r=﹣0.205,P=0.014),BMI(r=﹣0.195,P=0.019),heart rate(r=﹣0.216,P=0.009),Triglycerides(r=﹣0.198,P=0.025),interventricular septal thickness(r=﹣0.208,P=0.012),LV end-diastolic diameter(r=0.210,P=0.012),septum strain(r=0.438,P=0.000). Further regression analysis we found that HbA1c(B=﹣0.440,P= .000), septum strain (B=0.301, P=0.000),LV end-diastolic diameter (B=0.226, P=0.001), sex(B=﹣0.134, P=.043) were independently associated with RVGLS in the whole study population.RVGLS was the best diagnostic indicator for prediabetes and diabetes (AUC values of 0.689 and 0.731, respectively), and a cut-off value of RVGLS ≤18.95% had 85% sensitivity and 61% specificity for the diagnosis of prediabetes and ≤17.55% had 82% sensitivity and 58% specificity for the diagnosis of diabetes. Therefore, we believe that abnormally elevated hyperglycemia negatively affects the myocardial function of the right ventricle, The decrease of right ventricular systolic function may be related to left ventricular remodeling and myocardial strain. two-dimensional speckle tracking echocardiography can detect subtle changes in impaired right ventricular systolic function. HbA1c, septum strain, LV end-diastolic diameter, the sex were independent risk factors for RVGLS.
Effect Of Formulation On The Indoxacarb And Lufenuron Dissipation In Maize And Risk Assessment
Authors: Cheng Xi , Xiao Jinjing , Liu Yuanhui , Gao Qun , Fang Qingkui , Liao Min , Liang Bing , Hu Zhendi , Cao Haiqun 
Published: February 2022

Abstract
The supervised field trials were conducted in maize crops using nano-microemulsion (NM) and a commercial formulation of indoxacarb and lufenuron to evaluate the effect of nano-formulation on the dissipation pattern. A modified QuEChERS-UPLC-MS/MS method was utilized for sample analysis. Results showed that the initial deposits of indoxacarb and lufenuron in plants using nano-microemulsion were 0.98 mg/kg and 8.18 mg/kg at recommended dosage while using the commercial formulation, they were 0.85 mg/kg and 5.53 mg/kg, respectively. Moreover, half-life (t1/2) values of using nano-microemulsion were 1.25 d and 2.51 d, which were 33.16% and 16.33% shorter than indoxacarb lufenuron from the commercial formulation, suggesting that pesticide formulations have a moderate impact on the initial deposit and dissipation rate. The terminal residue test showed that indoxacarb and lufenuron residues in maize grain and maize straw were below the available maximum residue limit (MRL), suggesting 2% indoxacarb NM and 5% lufenuron NM are safe to use under the recommended dosage. The risk quotient value also revealed an acceptable risk for human consumption. These findings provide scientific evidence of the proper application of 2% indoxacarb NM and 5% lufenuron NM on maize crops.
SpaceQ -- Direct Detection of Ultralight Dark Matter with Space Quantum Sensors
Authors: Tsai Yu-Dai , Eby Joshua , Safronova Marianna 
Published: February 2022

Abstract
Recent advances in quantum sensors, including atomic clocks, enable searches for a broad range of dark matter candidates. The question of the dark matter distribution in the Solar system critically affects the reach of dark matter direct detection experiments. Partly motivated by the NASA Deep Space Atomic Clock (DSAC) and the Parker Solar Probe (PSP), we show that space quantum sensors present new opportunities for ultralight dark matter searches, especially for dark matter states bound to the Sun. We show that space quantum sensors can probe unexplored parameter space of ultralight dark matter, covering theoretical relaxion targets motivated by naturalness and Higgs mixing. If an atomic clock were able to make measurements on the interior of the solar system, it could probe this highly sensitive region directly and set very strong constraints on the existence of such a bound-state halo in our solar system. We present sensitivity projections for space-based probes of ultralight dark matter which couples to electron, photon, and gluon fields, based on current and future atomic, molecular, and nuclear clocks.