bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decreased Weight Loss Following Bariatric Surgery in Patients with Type 2 Diabetes
Authors: Rebelos Eleni , Moriconi Diego , Honka Miikka-Juhani , Anselmino Marco , Nannipieri Monica 
Published: November 2022

Abstract
Background
Bariatric surgery represents the most effective treatment for achieving significant and sustained weight loss. We aimed to assess whether presence of type 2 diabetes (T2D) at baseline, and T2D remission following bariatric surgery affect the weight loss outcome.

Methods
Data of 312 consecutive morbidly obese subjects who underwent bariatric surgery were analysed. Patients underwent either RYGB (77%), or sleeve gastrectomy (23%), and their body weight was followed-up for 1, 2, 3, 4, and 5 years at regular ambulatory visits (N = 269, 312, 210, 151, 105, at each year, respectively). T2D remission was assessed according to the ADA criteria.

Results
In the whole dataset, 92 patients were affected by T2D. Patients with T2D were older than patients without T2D (52 ± 9 vs 45 ± 11 years, p < 0.0001), but there were no differences in baseline BMI, sex, and type of intervention received. We found that presence of T2D at baseline was associated with smaller weight loss at 1, 2, 3, 4, and 5 years following bariatric surgery (δ BMI at 2 years: − 13.7 [7.7] vs − 16.4 [7.3] kg/m2; at 5 years − 12.9 [8.8] vs − 16.3 [8.7] kg/m2 in patients with T2D vs patients without T2D respectively, all p < 0.05). When dividing the patients with T2D in remitters and non-remitters, non-remitters had significantly smaller weight loss compared to remitters (δ BMI at 2 years: − 11.8 [6.3] vs − 15.4 [7.8] kg/m2; at 5 years: − 8.0 [7.1] vs − 15.0 [7.2] kg/m2, non-remitters vs remitters respectively, all p < 0.05).

Conclusions
T2D is independently associated to smaller weight loss following bariatric surgery, especially in subjects not achieving diabetes remission.

Graphical Abstract
• Patients with T2D achieve smaller weight loss following bariatric surgery
• When dividing the T2D patients in remitters and non-remitters, non-remitters achieve significantly smaller weight loss compared to remitters
Cilia in the Striatum Mediate Timing-Dependent Functions
Authors: Alhassen Wedad , Alhassen Sammy , Chen Jiaqi , Monfared Roudabeh Vakil , Alachkar Amal 
Published: November 2022

AbstractAlmost all brain cells contain cilia, antennae-like microtubule-based organelles. Yet, the significance of cilia, once considered vestigial organelles, in the higher-order brain functions is unknown. Cilia act as a hub that senses and transduces environmental sensory stimuli to generate an appropriate cellular response. Similarly, the striatum, a brain structure enriched in cilia, functions as a hub that receives and integrates various types of environmental information to drive appropriate motor response. To understand cilia’s role in the striatum functions, we used loxP/Cre technology to ablate cilia from the dorsal striatum of male mice and monitored the behavioral consequences. Our results revealed an essential role for striatal cilia in the acquisition and brief storage of information, including learning new motor skills, but not in long-term consolidation of information or maintaining habitual/learned motor skills. A fundamental aspect of all disrupted functions was the “time perception/judgment deficit.” Furthermore, the observed behavioral deficits form a cluster pertaining to clinical manifestations overlapping across psychiatric disorders that involve the striatum functions and are known to exhibit timing deficits. Thus, striatal cilia may act as a calibrator of the timing functions of the basal ganglia-cortical circuit by maintaining proper timing perception. Our findings suggest that dysfunctional cilia may contribute to the pathophysiology of neuro-psychiatric disorders, as related to deficits in timing perception.
Bond formation with pet-robots: An integrative approach
Authors: Díaz-Boladeras Marta 
Published: November 2022

AbstractThe challenge of long-term interaction between humans and robots is still a bottleneck in service robot research. To gain an understanding of sustained relatedness with robots, this study proposes a conceptual framework for bond formation. More specifically, it addresses the dynamics of children bonding with robotic pets as the basis for certain services in healthcare and education. The framework presented herein offers an integrative approach and draws from theoretical models and empirical research in Human Robot Interaction and also from related disciplines that investigate lasting relationships, such as human-animal affiliation and attachment to everyday objects. The research question is how children’s relatedness to personified technologies occurs and evolves and what underpinning processes are involved. The subfield of research is child-robot interaction, within the boundaries of social psychology, where the robot is viewed as a social agent, and human-system interaction, where the robot is regarded as an artificial entity. The proposed framework envisions bonding with pet-robots as a socio-affective process towards lasting connectedness and emotional involvement that evolves through three stages: first encounter, short-term interaction and lasting relationship. The stages are characterized by children’s behaviors, cognitions and feelings that can be identified, measured and, maybe more importantly, managed. This model aims to integrate fragmentary and heterogeneous knowledge into a new perspective on the impact of robots in close and enduring proximity to children.
Exploring the Dark side of conscientiousness. The relationship between conscientiousness and its potential derailers: perfectionism and narcissism
Authors: Coleman Geoff , Furnham Adrian , Treglown Luke 
Published: November 2022

AbstractThe current study aimed to identify what individual differences and situational variables cause derailment in highly conscientious people. Data were from a representative working sample of 716 participants across 27 industries, spanning both management and non-management roles. We tested four hypotheses with regard to bright- and dark-side personality traits and the relationship between boss/manager and staff member. Hierarchical linear regressions revealed mixed findings for Leader-Member Exchange (LMX) as a stressor. For maladaptive perfectionism it was confirmed, but not for adaptive perfectionism or narcissism. Results suggest introverts may be more prone to maladaptive perfectionism, even with higher levels of conscientiousness if there are lower LMX levels. Overall, the findings suggest selecting for conscientiousness alone and discounting other personality traits and situational variables may be detrimental in practice. Further implications are discussed alongside the study limitations.
Alteration of monocyte subsets and their functions in thalassemia patients
Authors: Piyajaroenkij Thanakrit , Tantiworawit Adisak , Khikhuntod Jeeraphong , Piriyakhuntorn Pokpong , Rattanathammethee Thanawat , Hantrakool Sasinee , Chai-Adisaksopha Chatree , Rattarittamrong Ekarat , Norasetthada Lalita , Fanhchaksai Kanda , Charoenkwan Pimlak , Thananchai Hathairat 
Published: November 2022

AbstractInfection is one of the leading causes of mortality in thalassemia patients. This study aimed to examine qualitative and quantitative changes in monocytes in thalassemia patients. Monocytes were isolated from peripheral blood mononuclear cells and separated into subpopulations by flow cytometry. Cytokine levels were measured using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) and sandwich enzyme-linked immunosorbent assay (ELISA). The primary endpoint was monocyte-derived TNF-α expression. A total of 78 patients and 26 controls were included. The mean log (TNF-α fold-change) by qRT-PCR was significantly lower in all thalassemia groups, at 1.27 in controls, versus 0.97 (p = 0.0014) in non-transfusion-dependent thalassemia (NTDT), 0.96 (p = 0.0004) in non-splenectomized transfusion-dependent thalassemia (TDT-NS), and 0.87 (p < 0.0001) in splenectomized transfusion-dependent thalassemia (TDT-S). Similarly, the mean 2-h TNF-α level measured by sandwich ELISA assay was significantly lower in all thalassemia groups, at 98.16 pg/mL in controls, versus 56.45 pg/mL (p = 0.0093) in NTDT, 39.05 pg/mL (p = 0.0001) in TDT-NS and 32.37 pg/mL (p < 0.0001) in TDT-S. Likewise, TDT patients had a significantly decreased percentage of non-classical monocytes, by approximately half compared to controls. Our results show that thalassemia major patients have clearly impaired monocyte counts and function.
Neural Correlates of Spatial Navigation in Primate Hippocampus
Authors: Mao Dun 
Published: November 2022

AbstractThe hippocampus has been extensively implicated in spatial navigation in rodents and more recently in bats. Numerous studies have revealed that various kinds of spatial information are encoded across hippocampal regions. In contrast, investigations of spatial behavioral correlates in the primate hippocampus are scarce and have been mostly limited to head-restrained subjects during virtual navigation. However, recent advances made in freely-moving primates suggest marked differences in spatial representations from rodents, albeit some similarities. Here, we review empirical studies examining the neural correlates of spatial navigation in the primate (including human) hippocampus at the levels of local field potentials and single units. The lower frequency theta oscillations are often intermittent. Single neuron responses are highly mixed and task-dependent. We also discuss neuronal selectivity in the eye and head coordinates. Finally, we propose that future studies should focus on investigating both intrinsic and extrinsic population activity and examining spatial coding properties in large-scale hippocampal-neocortical networks across tasks.
Regional differences in health further explained
Authors: Meisters Rachelle , Putrik Polina , Westra Daan , Bosma Hans , Ruwaard Dirk , Jansen Maria 
Published: November 2022

AbstractLike in most Western countries, regional health inequalities are also present in the Netherlands. Explaining these inequalities is necessary for policymakers to target interventions to reduce them. Regional health inequalities are usually attributed to demographic and socio-economic factors, while lifestyle and psychosocial factors are increasingly shown to impact individuals’ health. Therefore, this study analyses the role of lifestyle, loneliness, and self-mastery in explaining regional inequalities, in addition to demographic factors and SES, for self-rated health, presence of chronic diseases, and psychological distress. Analyses are performed in the linked dataset from the Dutch Public Health Services, Statistics Netherlands, and the National Institute for Public Health and the Environment for the year 2016 (n = 334,721). The results show that lifestyle, loneliness and self-mastery contribute to the regional health inequalities in self-rated health and presence of chronic diseases. For psychological distress, both loneliness and self-mastery contribute to the regional health inequalities. Addressing lifestyle and psychosocial factors can offer policymakers additional pathways to bridge regional health inequalities. In this study, the region of Zuid-Limburg represents the reference region. Use compare regions for health and healthcare costs (Regiovergelijker gezondheid en zorgkosten [1]) in order to select all other Dutch regions as reference region.
A data driven Dantzig–Wolfe decomposition framework
Authors: Basso Saverio , Ceselli Alberto 
Published: November 2022

AbstractWe face the issue of finding alternative paradigms for the resolution of generic Mixed Integer Programs (MIP), by considering the perspective option of general purpose solvers which switch to decomposition methods when pertinent. Currently, the main blocking factor in their design is the problem of automatic decomposition of MIPs, that is to produce good MIP decompositions algorithmically, looking only at the algebraic structure of the MIP instance. We propose to employ Dantzig–Wolfe reformulation and machine learning methods to obtain a fully data driven automatic decomposition framework. We also design strategies and introduce algorithmic techniques in order to make such a framework computationally effective. An extensive experimental analysis shows our framework to grant substantial improvements, in terms of both solutions quality and computing time, with respect to state-of-the-art automatic decomposition techniques. It also allows us to gain insights into the relative impact of different techniques. As a side product of our research, we provide a dataset of more than 31 thousand random decompositions of MIPLIB instances, with 121 features, including computations of their root node relaxation.
Testimonial Injustice: The Facts of the Matter
Authors: Arcila-Valenzuela Migdalia , Páez Andrés 
Published: November 2022

AbstractTo verify the occurrence of a singular instance of testimonial injustice three facts must be established. The first is whether the hearer in fact has an identity prejudice of which she may or may not be aware; the second is whether that prejudice was in fact the cause of the unjustified credibility deficit; and the third is whether there was in fact a credibility deficit in the testimonial exchange. These three elements constitute the facts of the matter of testimonial injustice. In this essay we argue that none of these facts can be established with any degree of confidence, and therefore that testimonial injustice is an undetectable phenomenon in singular instances. Our intention is not to undermine the idea of testimonial injustice, but rather to set limits to what can be justifiably asserted about it. According to our argument, although there are insufficient reasons to identify individual acts of testimonial injustice, it is possible to recognize recurrent patterns of epistemic responses to speakers who belong to specific social groups. General testimonial injustice can thus be characterized as a behavioral tendency of a prejudiced hearer.
Himalayan alpine ecohydrology: An urgent scientific concern in a changing climate
Authors: Leng Ruolin , Harrison Stephan , Anderson Karen 
Published: November 2022

AbstractClimate change is projected to have important impacts on snow and vegetation distribution in global mountains. Despite this, the coupling of ecological shifts and hydrological processes within alpine zones has not attracted significant scientific attention. As the largest and one of the most climatically sensitive mountain systems, we argue that Himalayan alpine ecohydrological processes require urgent scientific attention because up to 1.6 billion people rely on water supplies from the mountains. We review studies from global mountain systems to highlight the importance of considering ecohydrological impacts within Himalayan alpine zones (4100–6000 m.a.s.l), explaining mechanisms for interactions between snow and dwarf plants. Our findings highlight the paucity of monitoring stations within Himalayan alpine systems. We suggest that it is likely that alpine ecological shifts will impact hydrological processes, but we found that specific mechanisms and functional relationships are missing for Himalayan systems, so the strength and direction of ecohydrological relationships is currently unknown. We advocate for more purposeful and widespread monitoring efforts below glaciers and above the treeline, calling for new experiments to query the role of small plants within the Himalayan alpine hydrological system. We outline the need for community engagement with alpine ecohydrological experiments, and we explain how new snow and vegetation products derived from remote sensing observations have the potential to improve scientific understanding of the interacting effects of warming and ecohydrological factors in this sensitive region.
CoQ10 reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation
Authors: Frontiñán-Rubio Javier , Llanos-González Emilio , García-Carpintero Sonia , Peinado Juan Ramón , Ballesteros-Yáñez Inmaculada , Rayo Margarita Villar , de la Fuente José , Pérez-García Víctor M. , Perez-Romasanta Luis A. , Malumbres Marcos , Alcaín Francisco J. , Durán-Prado Mario 
Published: November 2022

Abstract
Purpose
Most monotherapies available against glioblastoma multiforme (GBM) target individual hallmarks of this aggressive brain tumor with minimal success. In this article, we propose a therapeutic strategy using coenzyme Q10 (CoQ10) as a pleiotropic factor that crosses the blood–brain barrier and accumulates in cell membranes acting as an antioxidant, and in mitochondrial membranes as a regulator of cell bioenergetics and gene expression.

Methods
Xenografts of U251 cells in nu/nu mice were used to assay tumor growth, hypoxia, angiogenesis, and inflammation. An orthotopic model was used to explore microglial infiltration, tumor growth, and invasion into the brain parenchyma. Cell proliferation, migration, invasion, proteome remodeling, and secretome were assayed in vitro. Conditioned media were used to assay angiogenesis, monocyte chemoattraction, and differentiation into macrophages in vitro.

Results
CoQ10 treatment decreased tumor volume in xenografts and orthotopic models, although its effect on tumor cell proliferation was not direct. Tumors from mice treated with CoQ10 were less hypoxic and vascularized, having less infiltration from inflammatory cells. Treatment-induced downregulation of HIF-1α and NF-kB led to a complete remodeling of the tumor cells proteome and secretome, impacting angiogenesis, monocyte infiltration, and their differentiation into macrophages. Besides, tumor cell migration and invasion were drastically restricted by mechanisms involving modulation of the actin cytoskeleton and downregulation of matrix metalloproteases (MMPs).

Conclusions
CoQ10 has a pleiotropic effect on GBM growth, targeting several hallmarks simultaneously. Thus, its integration into current treatments of this fatal disease should be considered.
Liminalität, Transdifferenz und Geschlecht: Sprachliche Praktiken jenseits von Zweigeschlechtlichkeit
Authors: Lind Miriam 
Published: November 2022

ZusammenfassungDie soziale Differenz Geschlecht und ihre sprachliche Repräsentation ist im deutschen Kulturraum binär organisiert. Für geschlechtliche Positionierungen jenseits der Kategorien Frau und Mann ist in der hegemonialen Geschlechterordnung und ihren sprachlichen Reflexen – bisher – kein Platz vorgesehen. Mit der zunehmenden Sichtbarkeit nichtbinärer Geschlechter wächst jedoch der Bedarf nach ihrer Versprachlichung. Der Beitrag erörtert mit Bezug auf die anthropologischen bzw. kulturwissenschaftlichen Konzepte der Liminalität und Transdifferenz die Probleme und Potenziale der sprachlichen Veruneindeutigung von Geschlecht und der neologistischen Kreativität, mit der neue Bezeichnungsmöglichkeiten außerhalb der Zweigeschlechtlichkeit geschaffen werden.
Conjectures of Sun About Sums of Polygonal Numbers
Authors: Bringmann Kathrin , Kane Ben 
Published: November 2022

AbstractIn this paper, we consider representations of positive integers as sums of generalized m-gonal numbers, which extend the formula for the number of dots needed to make up a regular m-gon. We mainly restrict to the case where the sums contain at most four distinct generalized m-gonal numbers, with the second m-gonal number repeated twice, the third repeated four times, and the last is repeated eight times. For a number of small choices of m, Sun conjectured that every positive integer may be written in this form. By obtaining explicit quantitative bounds for Fourier coefficients related to theta functions which encode the number of such representations, we verify that Sun’s conjecture is true for sufficiently large positive integers. Since there are only finitely many choices of m appearing in Sun’s conjecture, this reduces Sun’s conjecture to a verification of finitely many cases. Moreover, the bound beyond which we prove that Sun’s conjecture holds is explicit.
Analytical methods, molecular structures and biogeochemical behaviors of dissolved black carbon
Authors: Chen Yalan , Sun Ke , Wang Zhibo , Zhang Enyao , Yang Yan , Xing Baoshan 
Published: November 2022

AbstractDissolved black carbon (DBC) is one of the most active fractions in the black carbon (BC) continuum and plays a significant role in the global dissolved organic matter (DOM) pool. Connecting the BC pool between territorial and marine environments, the biogeochemical processes of DBC are significant for many aspects of aquatic chemistry. Once entering the aquatic environment, DBC will undergo degradation and exert continuing effects on water ecology. DBC can change the migration and transport of pollutants and affect associated microbial communities. Therefore, the knowledge of the fate and transport of DBC is of great importance. In this work, the molecular structures of different DBC were examined and summarized to provide a basis for understanding the environmental processes of DBC. Current research progress on the photodegradation of DBC, interactions between DBC and microorganisms, and the effects of DBC on the fate and transport of contaminants were critically reviewed. The qualitative and quantitative analytical methods for DBC were assessed in detail. To date, the environmental behaviors of DBC are far from fully understood in part due to the lack of systematic methods. Compared with the relatively well-studied photodegradation of DBC, microbial transformation of DBC is poorly understood. Moreover, DBC is exposed to continuous light illumination and microbial metabolization, thus the combined effects of photodegradation and biodegradation are crucial to the cycling and turnover of DBC in aquatic environment and deserve further investigations. In addition, research on the sorption processes, redox reactions and DBC-assisted photo-transformations of contaminants is still at its emerging stages.
Ruling the Country without Law: The Insoluble Dilemma of Transforming China into a Law-Governed Country
Authors: ZHANG Zhong 
Published: November 2022

AbstractDespite more than 40 years’ legislation to build a ‘law-governed country’ and the Communist Party of China (CPC)'s repeated proclaiming to ‘govern the country according to law’, China still lacks legislation concerning a constitutional matter that is central to its governance, ie, the powers of the CPC to rule. No law specifies its powers, and the CPC's rule is not based on law. Why has such a crucial and apparent loophole not been filled? It is essentially because of the CPC's insistence on supremacy with unchallengeable authority in the governance of China. Specifying in law the Party's powers, and how they should be exercised, would subject its rule to law and set a legal limit on its powers, which is irreconcilable with its goals of maintaining supremacy and absolute authority. Hence, an insoluble dilemma can be observed: while the CPC leadership wants China to become a law-governed country to attain lasting order and stability, they have to rule the country extralegally to avoid legal challenges to the supremacy of their rule. This article not only sheds light on this inherent contradiction, but also offers insight into the nature of the CPC's practice to ‘govern the country according to law’.