bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors for Catheter-Related Bloodstream Infection in Patients Undergoing Hemodialysis: A Systematic Review And Meta-Analysis
Authors: 李 瑛 , Hou lingyu , Shi Min , Ding xiaorong 
Published: September 2022

Abstract
Background: Catheter-Related Bloodstream Infection (CRBSI) is a common and life-threatening complication of hemodialysis, with high morbidity and mortality. This meta-analysis was performed to analyze the risk factors of CRBSI in patients undergoing hemodialysis.
Methods: The search process included the electronic databases of CNKI, WANGFANG, PubMed, EMBASE, the Cochrane Library, and Web of Science from inception to July 2021. The quality assessment of the included studies was conducted according to the Newcastle-Ottawa Scale (NOS). The Odds ratios (ORs) with corresponding 95% confidence intervals (95%CIs) were calculated to assess the strength of the association of risk factors with CRBSI using RevMan 5.4 software in the current study.
Results: A total of 23 pieces of literature were included in this study, counting a total of 10335 patients, including 1165 patients with CRBSI and 9170 patients without CRBSI. Meta analysis results showed that puncture times [OR=3.22, 95% CI (2.42, 4.27)], femoral vein catheterization (OR=1.69, 95%CI 1.38-2.08, P＜0.00001), catheter indwelling time (OR = 2.22, 95% CI 1.62-3.04, P < 0.0001), age (OR =1.69, 95%CI 1.49-1.91, P < 0.0001), diabetes mellitus (OR=1.92, 95%CI 1.71-2.15, P< 0.00001), dialysis time (OR = 2.89, 95%CI 1.82-4.59, P <0.0001), duration of hospitalization (OR =2.49, 95%CI 1.47-4.23,P =0.0006) and hypoproteinemia (OR =3.19, 95%CI 2.08-4.89, P＜0.0001) were risk factors for CRBSI.Conclusions: Catheter retention time, age, femoral vein catheterization, diabetes, hospitalization time and hypoproteinemia were risk factors for CRBSI in hemodialysis patients.
Long-lifetime water-washable ceramic catalyst filter for air purification
Authors: Kwon Hyuk Jae , Yang Dong Sik , Koo Min Seok , Ji Sang Min , Jeong Joonseon , Oh Sehyeong , Kuk Su Keun , Heo Hyeon-su , Ham Dong Jin , Kim Mi Jong , Choi Hyoungwoo , Lee Jong-Min , Shur Joong-Won , Lee Woo-Jin , Bin Chang-Ook , Timofeev Nikolay , Huiqing Wu , Wang Liming , Lee Taewoo , Jacob Daniel , Kim Jhoon , Lee Hyun Chul 
Published: September 2022

Abstract
Particulate matter (PM) and volatile organic compounds (VOCs) are recognised as hazardous air pollutants threatening human health1,2. Disposable filters are generally used for air purification despite frequent replacement and waste generation problems. However, the development of a novel regenerable and robust filter for long-term use is a huge challenge. Here, we report on a new class of facile water-washing regenerable ceramic catalyst filters (CCFs), developed to simultaneously remove PM (> 95%) and VOCs (> 82%) in single-pass by coating the inner and outer filter channels with an inorganic membrane and a Cu2O/TiO2 photocatalyst, respectively. The CCFs reveal four-fold increase in the maximum dust loading capacity (approximately 20 g/L) in relation to conventional filters (5 g/L)3, and can be reused after ten regeneration capability with simple water washing retaining initial PM and VOC removal performances. Thus, the CCFs can be well-suited for indoor and outdoor air purification for 20 years, which shows a huge increase in lifetime compared to the six-month lifespan of conventional filters. Finally, we believe that the development and implementation of CCFs for air purification can open new avenues for sustainable technology through renewability and zero-waste generation.
Impact of digital economy on ecological resilience of resource-based cities: Spatial spillover and mechanism
Authors: Tang Yan , Wang Yusu 
Published: September 2022

Abstract
The digital economy and the construction of ecological civilization are central issues in the sustainable development of resource-based cities, and the impact of the digital economy on the ecological resilience of resource-based cities deserves further consideration. This paper measures ecological resilience of 117 resource-based cities from 2011 to 2020 using the entropy weight TOPSIS method, and empirically investigates the impact and mechanism of digital economy on ecological resilience using the SDM model and intermediary effect model. The results show that: the ecological resilience of resource-based cities has a certain upward trend, with a stepwise distribution pattern from east to west. There is a significant positive correlation between ecological resilience of resource-based cities, showing the phenomenon of club convergence which is primarily dominated by H-H and L-L. The digital economy has a significant spatial spillover effect, which promotes ecological resilience in the local and adjacent regions. A mechanism analysis reveals that technological innovation plays a mediating role between digital economy and ecological resilience, with significant heterogeneity in region and growth cycle. Following the above findings, this paper proposes policy suggestions related to digital economy evolution and ecological resilience enhancement.
Why do small volcanic ocean islands collapse? Lessons from Santa Maria Island, Azores Triple Junction
Authors: Marques Fernando , Ribeiro Luisa , Costa Ana Cristina , Hildenbrand Anthony 
Published: September 2022

Abstract
Volcanic ocean island collapse is a gravitational process, therefore mass is a key variable. Based on this premise, islands much smaller than Hawaii are believed to be not prone to collapse. Here we show that they can collapse, and more than once, like in Santa Maria Island (Azores), 170 times smaller than Hawaii, as inferred from onshore data and new high-resolution bathymetry. Santa Maria sits on oceanic sediments hundreds of meters thick, the top of which is unconsolidated, water saturated and, therefore, soft. Numerical simulations indicate that, if the volcanic edifice is strong, it does not collapse, even if its base is weak. However, a relatively weak edifice can collapse over a weak base. We conclude that small volcanic islands can collapse when both the edifice and its base are weak. Our numerical simulations also indicate that, if the basal detachment only partially occupies the base of the volcano edifice (outer soft sediment ring less affected by pressure and temperature), the flank will only partially collapse. This could be the case of the Hilina Slump in the Big Island of Hawaii, because the large size of the edifice can produce high-grade metamorphism in the sediments at the core of the edifice’s base.
Perceived neighborhood environment walkability and health-related quality of life
Authors: Zhu Jiaqi , Kodali Hanish , Wyka Katarzyna , Huang Terry T.-K. 
Published: September 2022

Abstract
Background
Measures of the built environment such as neighborhood walkability have been associated with health behaviors such as physical activity, the lack of which in turn may contribute to the development of diseases such as obesity, diabetes, cardiovascular disease, and cancer. However, limited research has examined these measures in association with health-related quality of life (HR-QoL), particularly in minoritized populations. We examined the relationship between perceived neighborhood environment and HR-QoL in a sample of mostly Black and Latino residents in New York City (NYC).
Methods
This study utilized the baseline survey data from the Physical Activity and Redesigned Community Spaces (PARCS) Study among 1,252 residents [34.6% Black, 54.1% Latino, 80.1% female, mean(± SD) age = 38.8 ± 12.5) in 54 park neighborhoods in NYC. Perceived built environment was measured using Neighborhood Environment and Walkability Survey, and mental and physical HR-QoL was estimated using Short Form (SF)-12. Using factor analysis, we identified two subscales of neighborhood walkability: enablers (e.g., trails, sidewalks, esthetics) vs. barriers (e.g., high crime and traffic). In addition, we included a third subscale on neighborhood satisfaction. Generalized Estimating Equation models adjusted for demographics and BMI and accounted for the clustering effect within neighborhood. Multiple imputation was used to account for missing data.
Results
Mental HR-QoL was associated with barriers of walkability (β ± SE = -1.63 ± 0.55, p < 0.01) and neighborhood satisfaction (β ± SE = 1.55 ± 0.66, p = 0.02), after adjusting for covariates. Physical HR-QoL was associated with only barriers of walkability (β ± SE = -1.13 ± 0.57, p < 0.05).
Conclusions
Among NYC residents living in minoritized neighborhoods, mitigating negative aspects of the neighborhood environment may be more crucial than adding positive features in terms of HR-QoL. Our study points to the need to investigate further the role of the built environment in urban, minoritized communities.
The effects of combined spinal-epidural analgesia and epidural anesthesia on maternal intrapartum temperature: A randomized controlled trial
Authors: Yao Zhiping , Zhou Jingxin , Li Shuying , Zhou Wenqin 
Published: September 2022

Abstract

Background:Labor epidural analgesia has been suggested to be associated with intrapartum fever. We designed this study to investigate the effects of epidural analgesia and combined spinal-epidural analgesia on maternal intrapartum temperature.Methods:Four hundred healthy nullipara patients were randomly assigned to receive either epidural analgesia (EA group) or combined spinal-epidural analgesia (CSEA group). Maternal temperature was measured hourly after analgesia administration. The primary outcome was the incidence of maternal fever, and the secondary outcomes were the duration of analgesia, analgesia to full cervical dilation and analgesia to delivery. Neonatal outcomes and other basic labor events were also recorded.Results:Maternal temperature gradually increased with time in both analgesia groups during labor. However, the CSEA group had a lower incidence of maternal fever, and a lower mean maternal temperature at 5 h, 6 h, and 9 h after analgesia. In addtion, the CSEA group also had a shorter time of analgesia duration, analgesia to full cervical dilation, analgesia to delivery, and less dose of epidural local anesthetic than the EA group.Conclusion:Our findings suggest that combined spinal-epidural analgesia is associated with a lower risk of intrapartum fever than epidural analgesia.Trial registration:ChiCTR1900026606. Registered on 16/10/2019.
Relationship between toe standing test and cervical spondylotic myelopathy: a new clinical sign
Authors: Liu Lei , Song Feifei , Liu Guangpu , Ma Chao , Han Meng 
Published: September 2022

Abstract
Background
We have discovered a new phenomenon in clinical practice called the toe standing test (TST), which has never been described and reported before. Based on the correlation of the toe TST with the relevant clinical data of patients with cervical spondylotic myelopathy (CSM) to determine whether it can be used as a new sign for the CSM.
Methods
The clinical data related to patients who visited our hospital for spinal cervical spondylosis were retrospectively collected. The general data and demographic characteristics of the patients were counted. The location of compression, compression segment, cause of compression, continuity of cerebrospinal fluid signal, alteration of spinal cord signal, muscle strength of lower limbs, grip strength of both hands, muscle tone of both lower limbs, Hoffmann's sign, and cervical JOA score were counted. The results of TST in CSM patients were recorded. Patients were grouped according to whether their TST results were positive or not, and the general information and clinical data of the two groups were compared statistically.
Results
A total of 171 patients with CSM were included, with a mean age of 61.1053 ± 12.7395 years and a positive toe standing test rate of 45.029% (77/171). The CSM patients were divided into positive (n = 77) and negative groups (n = 94). The differences in cerebrospinal fluid signal continuity and cervical JOA scores between patients in different groups were statistically significant (P < 0.05). The differences in the results of the remaining observations were not statistically significant. The results of univariate regression analysis did not see the above-mentioned observables as risk factors.
Conclusion
TST is closely related to CSM, and patients with positive TST may have long-term compression of the cervical spinal cord. TST may be a new clinical sign of CSM, and combined with the cervical JOA score, this test can assess the severity of spinal cervical spondylosis.
Reliability and quality assessment of colorectal cancer content in video sites
Authors: Wen Hua , Lu Ning , li Qian , Cui Manli , Su Yuanyuan , Zhang Jie , Li jie , Fan ling , Quan Xin , Zhang Mingxin 
Published: September 2022

Abstract
Objective:To assess the content, reliability and quality of video information about colorectal cancer in video websites.
Methods: We searched for "colorectal cancer" on Youku, Tencent, Iqiyi, Bilibili, Watermelon, Douyin and Kwai, and studied the top 50 videos sorted by "relevance" in the search function, totaling 350 videos. Video characteristics and upload sources were recorded. Two independent gastroenterologists assessed the reliability and quality of the video information using the Global Quality Scale (GQS) and the DISCERN assessment tool.
Results: A total of 350 videos were analyzed. Note that a total of 350 videos were analyzed. The most common sources of uploads were public hospitals/medical colleges/doctors (45.8%), followed by independent health information websites (26.0%), medical advertisements/for-profit organizations (7.7%), individual users/patients (9.7%) and talk shows/TV programs (10.8%). Symptoms and diagnostic options (35.4%) were the most common video content, followed by general information (24.0%) and treatment (23.1%), lifestyle/diet habits (7.2%) and complications (10.3%) were the least common.Mean DISCERN and GQS ratings were 2.77 and 3.11, respectively. Videos uploaded by Public hospitals/medical schools/doctors were more reliable and of higher quality, with mean DISCERN and GQS ratings of 3.12 and 3.26, respectively. The average value of DISCERN score and GQS score is greater than 3 in the videos uploaded by Iqiyi, Bilibili and Watermelon.
Conclusion:Video websites are one of the main sources of colorectal cancer information on the Internet, but most of the content is of low to medium reliability and low to medium quality, with some risk of misinformation. Therefore it is especially important to upload high quality and optimal length video content. Meanwhile, organizations and personnel with medical professional background upload videos of higher quality, and they should be encouraged to actively participate in colorectal cancer video science.
Association between MHR and MAFLD: A Single-center Retrospective Study
Authors: Han Jing , Li Yawei , Guo Jinbo , Luo Yuxin , Zhang Baolian , Liu Hong , Zhang Xiaolan 
Published: September 2022

Abstract
Background
Metabolic dysfunction-associated fatty liver disease (MAFLD) has high incidences and is one of the major hepatic diseases. Chronic low-grade inflammation has been considered to be an important pathogenesis of MAFLD. Monocyte /HDL-C ratio (MHR) is a novel marker of inflammation and oxidative stress. This study attempted to explore the correlation between MHR and MAFLD.
Methods
This study enrolled a total of 705 adults with MALFD and 1,505 healthy subjects as the control group. All participants accepted the anthropometric and laboratory tests. MHR was acquired as monocytes count divided by high-density lipoprotein concentration. After adjusting sex, age, BMI, blood pressure, hepatic enzyme, uric acid, fasting glucose, triglyceride, LDL-C, smoking, hypertension, diabetes, hyperlipidemia, we analyzed the correlation between MHR and MAFLD.
Results
An increased MHR was identified in the MAFLD group, and MHR correlated with BMI, diabetes history, and metabolic abnormalities. Univariate and multiple logistic regression analysis showed that MHR was associated with MAFLD. After adjusting for potential confounders, a non-linear relationship was found between MHR and MAFLD, and the inflection point was 0.396 in the non-linear curve. On the left of the inflection point, MHR positively correlated with MAFLD (OR = 1.459, 95% confidence interval (CI): 1.196 to 1.781, p < 0.001). However, there was no obvious relationship on the right (OR = 0.934, 95% CI: 0.797 to 1.096, p = 0.403). Interaction analysis showed that the association between MHR and MAFLD was significant in people less than 60, non-obese, without a history of diabetes, and without severe metabolic abnormalities.
Conclusion
MHR increased in adults with MAFLD. MHR positively correlated with MAFLD when less than 0.396. Therefore, MHR could be used as a predictor of MAFLD.
Systems Pharmacology Dissection of Pharmacological Mechanisms of Xiaochaihu Decoction against human coronavirus
Authors: Xu Lvjie , Cai Chuipu , Fang Jiansong , Wu Qihui , Zhao Jun , Wang Zhe , Guo Pengfei , liu Ailin , Zheng Lishu 
Published: September 2022

Abstract
Background
Coronavirus disease 2019 (COVID-19) pandemic is still raging worldwide, while the treatment of human coronaviruses (HCoVs) infections remains limited. Qingfeipaidu decoction (QFPDD), formulated by four classical prescriptions, was the most widely used prescription for COVID-19 containment and exhibited positive effects in China. As one critical prescription in QFPDD, Xiaochaihu decoction (XCHD) could relieve the symptoms of fever, fatigue, anorexia, sore throat in TCM theory. To explore the role and mechanisms of XCHD against HCoVs, we presented an integrated systems pharmacology framework in this study.
Methods
We constructed a global herb-compound-target network of XCHD against HCoVs. Subsequently, multi-level systems pharmacology analyses highlighted the key regulatory proteins of XCHD, and revealed that XCHD may affect multiple biological functions related to HCoVs. We further applied network-based prediction, drug-likeness analysis, combined with literature investigation to uncover the key ani-HCoV constituents in XCHD, while in vitro HCoV-229E virus-induced cytopathic effect assay was carried out to verify our prediction. Finally, we proposed molecular mechanism hypothesis for these compounds against HCoVs via subnetwork analysis.
Results
Based on the systems pharmacology framework, we identified 163 XCHD constituents connecting to 37 HCoV-associated genes. And an integrated pathway comprising TLR signaling pathway, RIG-1-like receptor signaling pathway, cytoplasmic DNA sensing pathway, and IL-6/STAT3 pro-inflammatory signal transduction axis was further proposed, revealing the mechanism of action of XCHD against HCoVs. Through in vitro assay, several constituents (e.g. betulinic acid, chrysin, isoliquiritigenin, schisandrin B, and (20R)-Ginsenoside Rh1) in XCHD exerted good inhibitory activity against HCoV-229E virus.
Conclusion
Our work presented a comprehensive systems pharmacology approach to explore the molecular mechanism and effective substances of XCHD against HCoVs.
An Overview of the Signs and Symptoms of Pediatric Patients Hospitalized with COVID-19
Authors: Aghdam Mojtaba Kamali , Sadeghzadeh Mansour , Yeganeh Pegah Moharrami 
Published: September 2022

Abstract
Introduction:
Clinical symptoms and laboratory findings of Covid-19 in children are more diverse than in adults. The aim of this study is to determine the clinical and laboratory findings of covid-19 in hospitalized children.
Materials and methods
This cross-sectional descriptive study was conducted on 57 children aged 1 month to 12 years who were admitted with Covid-19, and their diagnosis were confirmed by PCR method from March 2020 to November 2021 in Mousavi Hospital of Zanjan, Iran. Demographic data, clinical and laboratory findings of patients were recorded, and relevant information was analyzed.
Results
In this study, 57 children with Covid-19, PCR positive, including 26 boys (45.6%) and 31 girls (54.4%) were evaluated. The most common clinical findings were fever, cough, respiratory distress, vomiting, diarrhea and seizures with fever in 45 (78.9%), 30 (52.6 ),24 (42.1%), 21 (36.8%) ,18 (31.5) and 6 (10.5%) patients respectively. The most common laboratory findings were increased AST and ALT in 50 (87.7%) and 24 (42.1%) patients. Increased CRP and ESR were found in 21 (36.8%) and 15 (26.3%) patients, respectively. Lymphopenia and thrombocytopenia were reported in 14 (24.5%) and 4 (7.07%) patients, respectively.
Conclusion
The most common clinical manifestations of covid-19 in children were fever and cough. The increase of liver enzymes, especially AST, was significant in hospitalized children, while lymphopenia and thrombocytopenia were not common in affected children.
Distress Tolerance and Family Accommodation: Associations in Parents of Young People with Eating Disorder Behaviours
Authors: Zinser Jennifer , Hale Lucy , Jones Christina 
Published: September 2022

Abstract
Purpose.
Family accommodation has been identified as a maintaining factor for eating disorders, with families often caught up in behaviours that characterise the illness. Given that parents often accommodate symptoms of their child’s eating disorder to reduce family conflict and the young person’s distress, levels of parents’ distress tolerance may help explain the variability seen in accommodation. This study aimed to investigate the relationship between parental distress tolerance (specifically tolerance of negative emotions [TNE] and intolerance of uncertainty [IU]) and family accommodation, assess the role of illness severity, caregiver burden, and parents’ mental health on this association, and understand the findings in the context of the COVID-19 pandemic.
Methods.
Parents or carers (N = 84) of young people (aged < 18) with a suspected or diagnosed eating disorder completed an online survey comprising of screening questions, demographic and clinical information, validated questionnaires, and questions about the impact of the COVID-19 pandemic.
Results.
TNE but not IU, was significantly associated with family accommodation. Multiple regression analyses revealed when other significant correlates of accommodating behaviour were entered into the model (caregiver mental health and caregiver burden), only caregiver burden remained significantly associated with family accommodation. Bootstrapped mediation analysis indicated the association between TNE and family accommodation is fully mediated by caregiver burden.
Conclusion.
There is an association between parents’ TNE and accommodation behaviours, however this association was fully mediated by caregiver burden. Clinical implications include additional psychoeducation and therapeutic support for parents to reduce burden.
Level of Evidence.
Level V: Cross-sectional descriptive study.