bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of bone metastasis of hepatocellular carcinoma: Mallory hyaline bodies can lead to the correct cytological diagnosis
Authors: Kawasaki Makoto , Shioya Akihiro , Takata Mao , Tsubata Yumi , Okanemasa Yoshiiku , Takenaka Michiho , Terauchi Toshie , Yamashita Manabu , Kumagai Motona , Yamada Sohsuke 
Published: November 2022

AbstractHepatocellular carcinoma (HCC) accounts for most primary tumors of the liver. Although bone metastasis does not occur in a high percentage of patients, bone metastasis is often found first, which leads to the diagnosis of HCC. In this report, we describe a case of bone metastasis from HCC in which bone lesions were detected incidentally, and in which a cytological diagnosis was difficult to make. The patient was a 78‐year‐old man with a history of renal dysfunction after orthopedic surgery. He underwent a thorough examination after a bone tumor was incidentally found on abdominal CT. Plasmacytoma was suspected. Fine needle aspiration cytology revealed irregular clusters of medium‐to‐large atypical epithelioid polygonal cells with relatively abundant eosinophilic, somewhat granular cytoplasm, and indistinct cell borders, which led to a diagnosis of malignancy. Histologically and immunohistochemically, the tumor was diagnosed as bone metastasis of HCC. Re‐examination of the cytological specimen revealed characteristic Mallory hyaline bodies (MHBs). Immunohistochemistry using a cell transfer method revealed that they were positive for low molecular weight cytokeratin, Cam5.2, in a densely granular fashion. In this case, the cytological diagnosis of HCC was difficult to make due to the unclear cytoplasmic borders and absence of bile pigment. However, the identification of MHBs can potentially guide me to the correct cytological diagnosis.
Minor red blood cell antigen phenotyping of athletes sampled in international competitions
Authors: Cristina Mirotti Luciana , Renovato‐Martins Mariana , Du Rocher‐Silva Bárbara , Dudenhoeffer‐Carneiro Ana Carolina , Soares Felipe , Rahaman Khandoker Asiqur , Hasan Mahbub , Muresan Anca Raluca , Kwon Oh‐Seung , Son Junghyun John , Pereira Henrique Marcelo Gualberto 
Published: November 2022

AbstractBlood transfusion is performed by cheating athletes to rapidly increase oxygen delivery to exercise muscles and enhance their performance. This method is banned by the World Anti‐doping Agency (WADA). Heterologous or allogenic blood transfusion happens when blood from a different person is transfused. The method used to detect this type of doping is based on flow cytometry, by identifying variations in blood group minor antigens present on the red blood cells' surface. Transfusion practices have regained interest since the introduction of human recombinant erythropoietin detection method. It has been reported that the number of occurrences of two athletes sharing an identical phenotype in the same sport was five times higher than the theoretical populational probability. The present work describes the prevalence of 10 erythrocytes surface antigens in a population of 261 athletes from all five continents. The matching phenotype per sport is also described.
EMCDDA framework and practical guidance for naming synthetic cannabinoids
Authors: Pulver Benedikt , Fischmann Svenja , Gallegos Ana , Christie Rachel 
Published: November 2022

AbstractSynthetic cannabinoids (SCs), often sold as “legal” replacements for cannabis, are the largest group of new psychoactive substances monitored by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Currently, close to 240 structurally heterogeneous SCs are monitored through the European Union (EU) Early Warning System, and attributing consistent, informative, and user‐friendly names to SCs has been a challenge in the past. Over time, several naming conventions have been employed with the aim of making SCs more easily recognizable by non‐chemists, including regulators. To achieve this, the names assigned need to contain detailed information on the structural features present in the substance.This work provides a theoretical framework and a practical hands‐on guideline for consistent naming of SCs, which is easy to understand and can be applied by the forensic community, researchers, clinical practitioners, and policy‐makers. The proposed framework builds on the established letter code system for molecular building blocks (core, linker, linked group, and tail) implemented by the EMCDDA in 2013 and has been expanded to incorporate additional structural features through substitution. The scope of the issue of attributing semi‐systematic code names is illustrated, and earlier approaches used for naming SCs are discussed. The concepts and rules of the EMCDDA framework are described through a flowchart that provides a basis for naming new SCs, a graphical overview of the chemical diversity of SCs, and a detailed list of the SCs identified in the EU by the Early Warning System of the EMCDDA for reference.
Knowledge and perceptions of rural and urban communities towards small protected areas: Insights from Ghana
Authors: Afriyie Jerry Owusu , Opare Michael Asare , Hejcmanová Pavla 
Published: November 2022

AbstractConservationists recognize that protected areas (PAs) have limited prospects without the involvement and support of local people. People inherently express positive perceptions to nature and support for wildlife conservation. Yet, people in rural and urban communities may differ in their knowledge and perceptions of benefits and costs of nearby small‐size PAs, which induce a vital impact on the effectiveness of PAs and conservation goal achievements. We investigated local people's knowledge, perceptions, and attitudes around rural PAs (Bomfobiri Wildlife Sanctuaries, Shai Hills Resource Reserve, and Ankasa Conservation Area) and urban PAs (Owabi Wildlife Sanctuaries) in Ghana. Based on a questionnaire survey (928 respondents) in communities surrounding the parks, the perception of benefits from PAs was mainly for ecological reasons and did not differ between PAs. However, the perception of costs incurred by PAs differed between urban and rural PAs. The locals of the urban PA perceived fewer costs (crop damage from wildlife) than those in rural areas. Although there were significant differences between the urban and rural PA respondents, most respondents had positive attitudes toward the PA. Fifty‐five percent of the total respondents were satisfied with the active law enforcement carried out by PA staff to protect biodiversity. However, 41% and 33% of respondents expressed discontent with restrictions on the use of natural resources within PAs and lack of involvement in decision‐making, respectively. Of the sociodemographic factors investigated in all parks, men were more satisfied with the policies and governance of PAs than women due to the greater participation of men in many outdoor activities. Positive attitudes toward PAs suggest that despite conflicts, there is a straightforward understanding by local people about healthy ecosystems, which creates a common ground between conservationists and local communities for successful conservation in PAs.
High‐performance Flexible Symmetric Supercapacitor Based on Heterostructured PANI@MoS2 Nanocomposite Electrode
Authors: Xu Yuandong , Liu Binyang , Dong Chaoyang , Feng Haoyang , Wei Yajun , Zhang Xia 
Published: November 2022

AbstractThree‐dimensional (3D) heterostructured molybdenum disulfide (MoS2) is used as base materials for aniline monomer in situ polymerization on its surface. It is found that the aniline addition has a remarkable effect on the energy storage of the final compounds due to the improvement of the conductivity and structure stability combined with the synergistic effect between the two types of species. The optimal compound of PANI@MoS2‐150 not only shows a high capacitance value of 801.4 F ⋅ g−1 at a current density of 0.5 A ⋅ g−1 but also provides a high retention rate of 77.4 % after 10,000 cycles. The capacitance fading may be due to the increase of the internal resistance analyzed by EIS. Furthermore, a flexible symmetric supercapacitor based on PANI@MoS2‐150 has also been fabricated and the specific capacitance reaches 105 F ⋅ g−1 at a current density of 1 A ⋅ g−1. Impressively, the capacitance retention is larger than 100 % undergoing 10,000 cycles. Besides, the highest energy density of 21 Wh ⋅ kg−1 was obtained. Additionally, the fabricated symmetric supercapacitor demonstrates excellent flexibility.
Strong Photoelectric Properties of Mn‐Based Seleniumstannates with Alkali Metals as Structure‐Directing Agents
Authors: Teri Gele , Liu Xin , Li Na , Shele Muge , E Namila , Qi Liming , Bai Sagala , Baiyin Menghe 
Published: November 2022

AbstractIn recent years, chalcogenides have received a lot of attention because of their potential applications as photoelectric material. This work describes the synthesis of the quaternary seleniumstannates Cs2MnSnSe4 (1) and Rb2MnSnSe4 (2) using solvothermal methods. The structure of compound 1 consists of charge‐balanced Cs+ cation and one‐dimensional (1D) anion [MnSnSe4]n2− chain. Compound 2 possesses a unique two‐dimensional (2D) anion [MnSnSe4]n2− layer. It is noteworthy that the compounds exhibit a strong photocurrent response (ca. 45 μA/cm2 (1), ca. 80 μA/cm2 (2)). Moreover, methylene blue (MB) was investigated for its photocatalytic degradation properties. In order to better understand the relationship between optical properties and electronic structure, a theoretical study was conducted.
100 Years of Vitamin E: From Discovery to Commercialization
Authors: Müller Marc‐André , Schäfer Christian , Litta Gilberto , Klünter Anna‐Maria , Traber Maret G. , Wyss Adrian , Ralla Theo , Eggersdorfer Manfred , Bonrath Werner 
Published: November 2022

Abstract2022 marks the centenary of the discovery of vitamin E by Evans and Bishop, an important milestone in vitamin research. An enormous amount of scientific data related to the importance of its activity has been published on this micronutrient. Globally, researchers from industry and academia have contributed to improve and implement highly efficient and commercially viable production processes for vitamin E. All processes share a common final step, but differ in the generation of their key building blocks. Today, Vitamin E, accounts for a worldwide production of >75.000 t/a. Vitamin E is applied predominantly as feed supplement for various animal species and in addition is used in a variety of human applications. Moreover, its impressive antioxidative behavior enables frequent use as stabilizing ingredient in many product forms and final consumer applications. This review will provide the current state of science, with clear focus on highlighting the different routes for industrial syntheses of vitamin E. Furthermore, approaches directed towards successful product form development including suitable auxiliary substances combined with appropriate formulation technologies, as well as a broad variety of applications in animal and human nutrition and health will be discussed. Insights on isolation approaches, biosynthesis, and future trends complete the status of Vitamin E research.
Continuous Transport of Zn(II) by Ammonium Chloride Media via Supported Liquid Membrane System
Authors: Chen Long , Dang Weiqi , Lin Xiaohui , Chen Gen 
Published: November 2022

AbstractWith the gradual depletion of traditional zinc resources, the full use of various non‐traditional zinc‐containing resources has received intensive attention. However, the efficient recovery of zinc ions with low concentrations remains challenging. Here efficient and continuous recovery of zinc ions in ammoniacal chloride media by a flat supported liquid membrane system is achieved, using Cyanex923 and TBP mixed extractant as the membrane phase. This article discusses the synergistic effect between Aliquat336, Cyanex923 and TBP, the effects of feed pH, total ammonia concentration, Cl− concentration and temperature on Zn(II) transport.
Self‐powered 2D nanofluidic graphene pressure sensor with Serosa‐Mimetic structure
Authors: Ren Ziqi , Zhang Hang , Liu Nishuang , Lei Dandan , Zhang Qixiang , Su Tuoyi , Wang Luoxin , Su Jun , Gao Yihua 
Published: November 2022

AbstractHigh‐performance self‐powered pressure sensors have attracted much attention due to their potential applications in bionic limbs, healthy motion detection, medical devices, and other fields. However, existing devices are either imperceptible to the pressure direction or require an external power source as a driving force. Here, a pressure sensor inspired by the structure of serosal membranes is reported, which contains a novel partially reduced graphene oxide (prGO) membrane. In this Serosa‐Mimetic structured membrane, a narrow “Trail” structure containing COOH is considered as an ion filter and ion conductor, which facilitates the directional migration of cations under external stimuli, resulting in a directional flow of net charges, resulting in current (or voltage) signal. Therefore, the prGO‐Trail membrane can be used as an ion transport layer to facilitate self‐powered pressure sensing. This pressure‐driven output voltage (and current), produced by ion selectivity, is linear with the applied pressure. The fabricated self‐powered bionic pressure sensor has good performance, the optimized response sensitivity is 0.282 nA Pa−1, the response/recovery time is 90/110 ms, and long‐term stability (1000 cycles), which provides a meaningful design idea and a larger open field of vision for the next generation of self‐driving bionic pressure sensors.image
Evaluating the effect of digital game‐based nutrition education on anemia indicators in adolescent girls: A randomized clinical trial
Authors: Ghadam Omid Sabet , Sohrabi Zahra , Mehrabi Manoosh , Fararouei Mohammad , Shahraki Mansour , Hejazi Najme , Clark Cain C. T. , Mehrabani Sanaz , Gerami Shirin , Nouri Mehran 
Published: November 2022

AbstractIron deficiency anemia is the most common type of micronutrient deficiency in the world. Adolescence represents a period of increased risk of iron deficiency. Therefore, we aimed to determine the impact of nutrition education by a digital game on markers of iron‐deficient anemia in adolescent girls. In this study, 176 adolescent girls were randomly dichotomized into the intervention and control groups. At the beginning and the end of the intervention, knowledge, attitude, and practice of both groups were assessed by a questionnaire. Girls in the intervention group received the necessary education through a digital game during a 14‐week period, while those in the control group received basic nutritional education through PowerPoint and pamphlets. Additionally, serum transferrin, serum iron, transferrin saturation, ferritin, CBC difference, and total iron binding capacity (TIBC) tests were checked. In this study, nutrition education significantly increased the level of knowledge, attitude, and practice of adolescent girls regarding their diet (p ˂ .05). Hemoglobin level was also significantly raised (p ˂ .05). However, no significant effect was observed on other markers of iron‐deficient anemia, such as serum iron, TIBC, and hematocrit, in the intervention group compared with the control group (p ˃ .05). The results of this study indicated the positive impact of nutrition education based on digital game on knowledge, attitude, and practice scores, as well as a significant difference in hemoglobin. It is recommended that educational games be designed for students in the future to promote health and nutrition information.
Dynamic estimates of geologic CO2storage resources in the Illinois Basin constrained by reinjectivity of brine extracted for pressure management
Authors: Plampin Michelle R. , Anderson Steven T. , Finsterle Stefan , Cahan Steven M. 
Published: November 2022

AbstractGeologic carbon storage (GCS) is likely to be an important part of global efforts to decarbonize the energy industry. Widespread deployment of GCS relies on strategies to maximize CO2injection rates while minimizing reservoir pressurization that could induce seismicity and/or fluid leakage into groundwater resources. Brine extraction from CO2storage formations with subsurface reinjection elsewhere could mitigate pressure buildup associated with GCS. Therefore, evaluation of CO2storage resources should consider the injectivity of produced brine in geologic layers above or below the CO2storage formation. For this study, a methodology was developed to estimate brine injectivity from formation depth and thickness using flow modeling and optimization techniques. The methodology was demonstrated in the Illinois Basin, where GCS in the Mt. Simon Sandstone is ongoing. Based on pressure constraints and considering only regions of the shallower units where salinity and sealing conditions were met, maximum brine injection rates were estimated within the Mt. Simon and three overlying hydrostratigraphic layers. Results indicate that a large area exists where CO2injectivity could be optimized by brine extraction and reinjection. © 2022 The Authors.Greenhouse Gases: Science and Technologypublished by Society of Chemical Industry and John Wiley & Sons Ltd.
Mental distress and incident functional disability among a rural ageing population in South Africa
Authors: Pengpid Supa , Peltzer Karl 
Published: November 2022

AbstractObjectivesThe aim of the study was to investigate the association between mental symptoms and incident functional disability among middle‐age and older adults in South Africa.MethodsLongitudinal data from two consecutive population surveys (2014/2015–2018/2019) in Agincourt, South Africa, were analysed.ResultsIn total, 298 of 3813 participants without functional disability in wave 1 (8.8%) had functional disability in wave 2. The prevalence of baseline functional disability was 9.1%.In the fully adjusted models for people without functional disability at baseline, depressive symptoms (AOR: 1.74, 95% CI: 1.08–2.80) among men and lower life satisfaction among men (AOR: 0.86, 95% CI: 0.80–0.93) and among women (AOR: 0.90, 95% CI: 0.83–0.98) increased the odds of incident functional disability. Posttraumatic stress disorder symptoms, poor sleep quality, restless sleep, and loneliness were not significantly associated with incident functional disability.ConclusionsDepressive symptoms among men and lower life satisfaction among both sexes were independently associated with incident functional disability in ageing rural South Africans.
Treatment indications and potential off‐label use of antidepressants among older adults: A population‐based descriptive study in Denmark
Authors: Ishtiak‐Ahmed Kazi , Liu Xiaoqin , Christensen Kaj Sparle , Gasse Christiane 
Published: November 2022

AbstractObjectivesOff‐label prescriptions of antidepressants may be of special concern in older‐adults. We aimed to study the potential off‐label use of antidepressants among adults ≥65 years by describing the patterns, trends, and factors associated with missing and unspecified treatment indications.MethodsWe used registry data to describe indications of all antidepressant prescriptions (N = 13.8 million) redeemed by older‐adults in 2006–2019. We investigated factors associated with off‐label use by considering prescriptions with missing and unspecified indications of the first antidepressant prescription using a multinomial logistic regression with the ‘depression’ indication as a reference category and reported odds ratios (ORs) with 95% confidence intervals (CI).ResultsOverall, 18.1% of all antidepressant prescriptions had missing indications, and 9.9% had unspecified indications. The proportion of potential off‐label use based on missing and unspecified prescriptions remained mostly consistent during 2006–2019. We identified similar associations in user characteristics whether considering missing or unspecified first prescription. ORs with 95% CI were raised in non‐western ethnicity (vs. Danish, 1.12 (0.99–1.26) for missing indication and 1.28 (1.11–1.48) for unspecified indication) and female sex (vs. male, 1.05 (1.02–1.07) and 1.05 (1.02–1.07) respectively). ORs were reduced for shorter educational attainment (vs. long, 0.90 (0.87–0.94) and 0.92 (0.88–0.96)), older age (≥81 vs. 67–70 years, 0.66 (0.65–0.71) and 0.73 (0.70–0.76)) and hospital psychiatric diagnosis (per diagnosis 0.76 (0.73–0.78) and 0.88 (0.86–0.91)).ConclusionsNearly one‐third of all antidepressant prescriptions redeemed by older‐adults in Denmark had either missing or unspecified treatment indications. Whether these prescriptions were actual off‐label use needs to be validated. Clinicians should pay special attention to patients' characteristics linking missing and unspecified indications and maintain adequate documentation while prescribing medication.
Novel stapler‐assisted technique for closure of persistent tracheoesophageal puncture fistula
Authors: Buncke Michelle , Andersen Peter , Connelly Christopher , Clayburgh Daniel 
Published: November 2022

AbstractTracheoesophageal puncture (TEP) is a reliable method to restore voice and is an important part of voice rehabilitation following laryngectomy. However, complications following this procedure, including peri‐prosthetic leakage and resulting aspiration pneumonia, may necessitate surgical closure. In this study, we present an effective and reliable method for TEP closure using a stapler‐assisted technique. Case series study for patients who underwent stapler‐assisted TEP closure reviewed from 2017 to 2021. All five patients had successful closure of their TEP tract without further leakage. No postoperative bleeding, wound infection, or esophageal stenosis occurred. One patient had postoperative stomal stenosis. The stapler‐assisted technique for TEP closure is easy, quick, and effective. The reliability and quick return to oral intake post‐operatively make it a preferable option over previous techniques.
Impact of time between faecal immunochemical tests in colorectal cancer screening on screening results: A natural experiment
Authors: Ribe Sara G. , Botteri Edoardo , Løberg Magnus , Randel Kristin R. , Kalager Mette , Nilsen Jens Aksel , Gulichsen Elisabeth H. , Holme Øyvind 
Published: November 2022

AbstractRepeated rounds of faecal immunochemical testing (FIT) for occult blood is a common method for screening for colorectal cancer (CRC). However, the time interval between FIT rounds is not thoroughly investigated. In a CRC screening trial in South‐Eastern Norway, individuals were invited for biennial FIT between 2012 and 2019. The positivity threshold was >15 mcg haemoglobin/g faeces (mcg/g). Due to organizational challenges, the interval between screening rounds randomly varied between 1.5 and 3.5 years, forming a natural experiment. We investigated the detection rate of CRC and advanced neoplasia (AN: CRC or advanced adenoma) at the subsequent round (FIT2), according to the faecal haemoglobin concentration (f‐Hb) at the initial screening round (FIT1), and time between the two screening rounds. 18 522 individuals with negative FIT1 who attended FIT2 were included in this study. 245 AN were detected at FIT2, of which 34 were CRC. The CRC detection rate at FIT2 for participants with FIT1 = 0 mcg/g was 0.09% while it was 0.28% for participant with 0 > FIT1 ≤ 15 mcg/g; odds ratio (OR) 3.22, 95% CI 1.49‐6.95. For each 3 months' increment between FITs, the OR for detecting CRC was 1.33 (95% CI 0.98‐1.79), while the OR was 1.13 (1.02‐1.26) for AN. Individuals with FIT1‐value of 0 mcg/g, had a lower AN detection rate compared with participants with 0 > FIT1 ≤ 15 mcg/g, irrespective of time between tests. Although CRC and AN detection rates increase with increasing time interval between FITs, individuals with undetectable f‐Hb at first screen have substantially lower risk of CRC at the next screening round compared with individuals with detectable f‐Hb.