bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Initial Validation of The Addressing Client Needs with Social Determinants of Health survey (ACN: SDH)
Authors: Johnson Kaprea F 
Published: July 2022

Abstract
Background
The purpose of this study was to validate a survey that can be used by healthcare systems, educators, and researchers to assess healthcare provider SDOH competency; with competency defined as their knowledge, awareness-biases, skills, and actual preparedness to address SDOH challenges.
Methods
An Exploratory Factor Analysis (EFA) was conducted with a sample of 220 healthcare providers, and 6 factors were identified. A Confirmatory Factor Analysis (CFA) was conducted with 303 healthcare providers and the 6-factor solution was supported, with 22 items.
Results
The reliability estimates for the 6 factors are as follows: Factor 1, Action Toward Addressing SDOH (a = .848); Factor 2, SDOH Knowledge (a = .944); Factor 3, Negative Attitude toward Addressing SDOH (a = .790); Factor 4, Systemic Accountability (a = .808); Factor 5, School Preparation (a = .863); and Factor 6, Perception of the Cause of SDOH (a = .940).
Conclusion
The ACN:SDH scale is the first validated measure that can be used to systematically appraise healthcare provider SDOH competency.
The impact of COVID-19 vaccination on renal function in patients with chronic kidney disease
Authors: Chuang Tzung-Fang , Hung Chin-Tun , Hung Hung-Chang , Yeh Jeo-Ting , Pai Jar-Yuan 
Published: July 2022

Abstract
Background
Patients with chronic kidney disease (CKD) are at high risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Newly developed SARS-CoV-2 vaccines have been proven to be effective against infection during the COVID-19 pandemic. The vaccines are safe for patients with CKD, with only sporadic cases of nephrotic syndrome or acute kidney injury (AKI) having been reported following COVID-19 vaccination. However, the causal relationship between vaccines and AKI remain to be identified. To our knowledge, no cohort study has investigated the impact of COVID-19 vaccination on renal function in patient with CKD. Therefore, we conducted a retrospective study to investigate changes in renal function after vaccination.
Methods
318 CKD patients with CKD in stage 3 to 5 received two doses of the COVID-19 vaccine. Changes in the estimated glomerular filtration rate (eGFR) and urine protein creatinine ratio (UPCR) were measured between before and after vaccination and compared with relevant values in the previous year (control period).
Results
The average changes in eGFR between before and after COVID-19 vaccination and during the control period were 1.52 ± 0.63 (SEM) and − 0.95 ± 0.74 mL/min/1.73m2, respectively. The mean difference was 2.47 mL/min/1.73m2 (95% confidence interval [CI], 0.69–4.25; p = 0.007). The average changes in UPCR between before and after COVID-19 vaccination and during the control period were 296.16 ± 73.35 and 40.32 ± 51.30 mg/g, respectively. The mean difference was 336.48 mg/g (95% CI, 165.14–507.83; p < 0.001).
Conclusions
COVID-19 vaccination could result in increased eGFR and UPCR in patients with CKD.
Vertex dominated superconductivity in intercalated FeSe
Authors: Acharya Swagata , Katsnelson Mikhail , Schilfgaarde Mark 
Published: July 2022

Abstract
Bulk FeSe becomes superconducting below 9K, but the critical temperature Tc is enhanced almost universally by afactor of ∼4-5 when it is intercalated with alkali elements. How intercalation modifies the structure is known from in-situ X-ray and neutron scattering techniques, but why Tc changes so dramatically is not known. Here we show that the enhancement originates mainly from modifications of the pairing vertex in the particle-particle channel. Thus, intercalated FeSe provides an archetypal example of superconductivity where information derived from the single-particle electronic structure is not sufficient to account for the origins of superconductivity, even when they are computed including correlation effects.
Microvesicles released from ectopic endometrial foci as a potential biomarker of endometriosis
Authors: Kajdos Magdalena , Szymański Jacek , Jerczyńska Hanna , Stetkiewicz Tomasz , Wilczyński Jacek 
Published: July 2022

Abstract
Purpose: Angiogenesis is engaged in endometriosis. It is regulated by regulatory factors and cytokines, transported in microvesicles. The purpose was to investigate the presence of MVs with vascular endothelial growth factor (VEGF) and metalloproteinase-9 (MMP – 9) in peripheral blood and peritoneal fluid of women operated on for endometrioma or teratomaMaterial and method: Microvesicles (MVs) were determined in blood samples and peritoneal fluid samples collected from women aged 20-60 years operated on for endometriosis (test group) and teratoma (control group). The final investigations were performed on 47 patients, who qualified for the study based on the meticulous inclusion criteria. MVs were analyzed by flow cytometry (FACS) using annexin V, antibodies for molecules characteristic of cells from endometriosis foci (keratin 18 (K18), CD105, CD146), and antibodies for intraepithelial vascular growth factor VEGF and metalloproteinase - 9 (MMP - 9). The sample was double “reading” using flow cytometry (FACSCantoII). Results: Cytometry analysis confirmed MVs’ presence in plasma and peritoneal fluid collected from patients with both endometriosis and teratomas. A statistically significant higher level of AnnexinV (+) MVs were observed in plasma samples of endometriosis patients. In the control group, there was a higher percentage of double-positive VEGF (+) / MMP9 (+) and single MMP9 (+) positive MVs in the serum. In the peritoneal fluid higher frequency of double-positive VEGF (+),/MMP9 (+) MVs were found in the control group. However, the amount of VEGF (+) / MMP9 (+) MVs object did not enable to differentiate between the test and control groups. The study was the first, in which MVs were confirmed in plasma and peritoneal fluid in benign adnexa tumors. Conclusion: Microvesicles are present in peripheral blood and peritoneal fluid samples collected from patients with endometriosis and teratomas. Microvesicles with proangiogenic factors (VEGF and MMP-9) are more abundant in blood and peritoneal fluid samples from patients with teratomas.
Antiarrhythmic properties of Botulinum toxin A: in vitro studies on human and rat cardiomyocytes
Authors: Nizamieva Aygul , Frolova Sheida , Slotvitsky Mihail , Kovalenko Sandaara , Tsvelaya Valeria , Nikitina Anna , Sergeevichev David , Agladze Konstantin 
Published: July 2022

Abstract
Botulinum toxin A is well known as a neurotransmitter inhibitor with a wide range of applications in modern medicine. In recent years, botulinum toxin preparations have begun to be used in clinical trials to suppress cardiac arrhythmias, especially in the postoperative period. Its antiarrhythmic action was associated with inhibition of the nervous system of the heart, while the question of a direct effect on the heart tissue remained unclear. In our work, we investigated the effect of botulinum toxin both on isolated cardiac cells and on layers of cardiac cells capable of conducting excitation. As an object of research, cardiomyocytes of neonatal rat pups and human cardiomyocytes obtained by the method of cell reprogramming were used. A patch-clamp study showed that botulinum toxin inhibited fast sodium current and L-type calcium current in a dose-dependent manner, with no apparent effect on potassium currents. It was shown by optical mapping that in the presence of botulinum toxin, the propagation of the excitation wave in the layer of cardiac cells slows down sharply, conduction at high concentrations becomes chaotic, but reentry waves do not form. It was found that the combination of botulinum toxin with a preparation of chitosan has an order of magnitude stronger inhibitory effect. It has been shown that the inhibitory effect of botulinum toxin is not permanent and disappears after 12 days of cell culture in a botulinum toxin-free medium.
Prevalence of antenatal depression and associated factors of continuous three trimesters depression: A multicentre study in Chengdu, China
Authors: Huang Xiuhua , Wang Ying , Wang Yuqiong , Guo Xiujing , Zhang Ling , Wang Wenxia , Shen Jing 
Published: July 2022

Abstract
Background
Antenatal depression (AD) is a major depressive disorder during pregnancy, which may lead to devastating sequelae for the expectant mothers and infants. This study aims to investigate the prevalence of (AD), and to explore influence factors of AD among pregnant women of continuous three trimesters in Chengdu, China.
Methods
The prospective study included pregnant women who were in their first, second and third trimester pregnancy and were recruited from four maternity hospitals by using the method of stratified and convenient sampling from March 2019 to May 2020 in Chengdu, China. These women completed questionnaires that included the Chinese validated versions of the Edinburgh Postnatal Depression Scale (EPDS) and questions related to health status, cognition, and soci-demographic variables to measure AD. The chi-square test and multivariate binary logistic regression was used to analyze.
Results
A total of 4560 pregnant women were recruited, 1051 women completed the whole study. The prevalence of depression symptoms during the first, second and third trimesters were 32.92% (346/1051), 19.79% (208/1051) and 20.46% (215/1051), respectively. During all stages group depression (77), the relations with parents-in-law, the marital relationship, and recent major negative life events, fear about dystocia and taking care of baby were the independent influencing factors of the depression (P < 0.05) compared with no risk depression group (571). The marital relationship, and recent major negative life events, fear about dystocia and the father desired sex of the baby (male) were the independent influencing factors of the depression (P < 0.05) compared with the depression of any one trimester (268). The father desired sex of the baby (male) was the independent influencing factors of the depression (P < 0.05) compared with the depression of any two stages (135).
Conclusion
The incidence and levels of depression in the first trimester of pregnancy are the highest. Therefore, it’s important to focus on the psychological status of pregnant women, especially the first trimester. The study suggested it’s necessary to establish a good marital relationship, to have the confidence of childbirth, and change the attitude of the father desired sex of the baby (male).
Optimization of reinjection well placement in the fault-controlled hydrothermal system using numerical simulation
Authors: Yao Yahui , Xiang Hong , Jia Xiaofeng 
Published: July 2022

Abstract
Geothermal tail water reinjection is an effective measure to maintain the sustainable production of geothermal resources and prevent the problems of geological environment. In order to avoid excessive thermal breakthrough and pressure drop of the geothermal reservoir, it is very necessary to optimize the distance between the production and reinjection wells. Here in this work, based on the conceptual model of hydrothermal genesis in Yanggao-Tianzhen Basin, a fault-controlled hydrothermal system, optimization of reinjection well placement has been conducted by using numerical simulation which incorporates all the geological and physical processes. Considering the different distance and upstream and downstream positions of production and reinjection wells, the temperature field evolution of the geothermal reservoir and the water pressure evolution in the production well were compared under each case condition. The temperature field evolution revealed that the shorter distance between production and injection wells, the faster the thermal breakthrough. When the reinjection well is located in the upstream of the production well, the thermal breakthrough will be faster than in the downstream. The water pressure evolution in the production well showed that the water level of the production well decreased insignificantly during the simulation time. It is found that the reservoir pressure can be basically maintained conditional on the whole geothermal tail water is reinjected. Based on the above research results, it is better to place the reinjection well at 1km in downstream of the production well. The findings are helpful for the sustainable exploitation of geothermal reservoir.
Are Thermotolerant and Osmotolerant Characteristics of Acanthamoeba Species an Indicator of Pathogenicity?
Authors: Kahraman Merve , Polat Zübeyda Akın 
Published: July 2022

Abstract
Acanthamoeba species are amoebae commonly found in nature. Acanthamoeba species were classified using the 18S ribosomal RNA gene sequence and have been divided into 23 genotypes called T1-T23 to date. The aim of this study is to compare the osmotolerance and thermotolerance characteristics of Acanthamoeba strains isolated from environmental and keratitis cases among genotype groups, within species with the same genotype, and to evaluate the relationship between pathogenicity in Acanthamoeba strains with T4, T5, T11 and T12 genotypes. In this study, after axenic cultures of 22 Acanthamoeba strains with T4 (Neff, A, B, D, E), T5, T11 and T12 genotypes isolated from clinical and environmental samples, thermotolerance (37°C, 39°C and 41°C) was determined and osmotolerance (0.5, 1 M) tests were performed. As a result; All strains showed growth ability at both 37°C and 0.5 M osmolarity. While all 5 strains isolated from patients with Acanthamoeba keratitis showed growth ability at 37 oC and 0.5 M osmolarity, no growth was detected at 41 oC and 1 M osmolarity. When the tolerance characteristics of the strains with the same genotype were evaluated, the strains with the T5 and T4E genotypes exhibited the same characteristic. When Acanthamoeba strains with T4 genotype were evaluated in general, 31.25% of the strains were found to grow at 39 oC and 6.25% at 41 oC. While the strain with the T11 genotype grew at all temperatures, the strain with the T12 genotype did not grow at 41 oC. According to our research results, we believe that tolerance to 39 oC and 1M mannitol is not an indicator of pathogenicity. In order to clarify this issue, more studies with Acanthamoeba strains are needed.
RAC1: Comprehensive Analysis of Genetic Alteration, Prognostic and Immunological Role Over Tumor Profiles
Authors: Wu Qionghui , Li Yonghong , Wang Chenyu , Chen Shanlin , Wei Haidong , Zhou Juanping , Chen Wei , Chen Deyi , Zhang Zhenchang , Su Gang 
Published: July 2022

Abstract
Background
RAC1 is involved in many physiological processes such as cytoskeleton regulation, and is highly related to the occurrence and development of various tumors. The global characterization of RAC1 in different tumor backgrounds is necessary to understand the mechanism of RAC1 involved in tumor progression
Methods
Based on the data of The Cancer Genome Atlas (TCGA), Gene Expression Omnibu (GEO), Human Protein Atlas (HPA), Genotype-Tissue Expression (GTEx) and so on, this paper comprehensively expounded the expression and prognosis of RAC1 in different tumors, and further analyzed the effects of genetic changes (gene mutation, epigenetic changes) of RAC1 on expression and immune infiltration on prognosis.
Results
RAC1 was highly expressed in most tumors and was associated with poor prognosis. Gene mutation, alternative splicing events and methylation of RAC1 may affect the abnormal expression of RAC1 in tumors. Interestingly, we found that RAC1-related immune cell infiltration was consistent between endothelial cells and fibroblasts, and RAC1-related macrophage infiltration in LIHC and LUAD was consistent with poor patient outcomes.
Conclusions
We have enriched the tumor-promoting role of RAC1 in different tumor profiles as a whole and speculated the intrinsic link, providing a basis for the search for potential biomarker.
Complications of Primary Total Hip Arthroplasty Among Patients with Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and Primary Osteoarthritis
Authors: Lian Qiang , Lian Yun , Yang Qinfeng , Li Kunlian , Zheng Yiqiao , Shi Zhanjun , Wang Jian 
Published: July 2022

Abstract
Background: Limited information exists comparing the perioperative complications of the different inflammatory arthropathies (IAs) after total hip arthroplasty (THA). Our study was aimed to (1) compare perioperative complications and (2) determine the most common complications between the different IA subtypes compared with patients with primary osteoarthritis（OA） undergoing primary THA and （3）find whether the difference in postoperative complications also exists between different IA after THA.Methods: The Nationwide Inpatient Sample ((NIS) was used to identify patients with Rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis (AS), and primary OA undergoing unilateral THA between 2005 and 2014. Preoperative diagnosis, comorbidities, and postoperative complications were determined using the International Classification of Disease Clinical Modification version 9 codes. The prevalence of perioperative complications was compared between patients with IA and primary OA and between patients with different IA.Results: When compared with patients with primary OA, patients with RA had significantly more postoperative surgical and medical complications. Yet there are just several medical complications differences exist between PA and primary OA or AS and primary OA, including stroke and acute renal failure for psoriatic arthritis and urinary tract infection and pneumonia for AS. What is more, there were also several differences in perioperative medical complications seen in patients with different IA.Conclusion: Except for patients with RA, the differences in perioperative complications was small between patients with IA and primary OA and between patients with different types of IA.
Improved Whale Algorithm for Economic Load Dispatch Problem in Hydropower Plants and Comprehensive Performance Evaluation
Authors: Yang Kun , Yang Kan 
Published: July 2022

Abstract
A novel method for economic load dispatch problem (ELDP) based on improved whale optimization algorithm(IWOA) is presented, and the optimization performance of IWOA in ELDP was evaluated comprehensively. The search mechanism is modified to improve the ability of the algorithm to jump out of the local optimal. The adaptive nonlinear inertia weight is introduced to improve the convergence speed of the algorithm. A limited mutation mechanism is proposed to improve the convergence of the algorithm. The evaluation indicator of calculation time and calculation accuracy was established. Taking 26 units of the Three Gorges Hydropower Station as an example, limited adaptive genetic aigorithm (LAGA), particle swarm optimization (PSO), whale optimization algorithm (WOA) and improved whale optimization algorithm (IWOA) were used to solve ELDP. The result shows that IWOA is superior to other algorithms in calculation results of various heads and loads. The calculation accuracy of IWOA was better than WOA when the number of units turned on was more than 8. The analysis results of IWOA and DP show that the calculation time of IWOA is better than that of DP when the number of units turned on is more than 6. The IWOA and the evaluation indicators proposed in this paper provide a new way for solving ELDP of large hydropower stations.
Mutator-derived lncRNAs drive genomic instability and represent a kind of prognostic marker for glioma
Authors: Li Shenglun , Chen Yujia , Guo Yuduo , Xu Jiacheng , Wang Xiang , Ning Weihai , Ma Lixin , Qu Yanming Qu , Zhang Mingshan Zhang , Zhang Hongwei 
Published: July 2022

Abstract
Glioma is the most common malignant tumor in brain and it has abundant long non-coding RNAs (lncRNAs), However, the specific role of lncRNAs and its mechanism in glioma remain unclear. LncRNA is a valuable cancer biomarker and they have been reported to be involved in genomic instability. Moreover, lncRNAs related to genomic instability has not been reported in glioma. In this study, we performed a prognostic model constructed with genomic instability-associated lncRNAs and further validated it with mutation correlation analysis, model comparison, independent prognostic value analysis, clinical stratification, examination of the external data set and cell line validation. This model provides us with a new kit for evaluating the prognosis of glioma.
Quantitative evaluation of changes in lower limb skeletal muscle activity after 3 months of continuous foot intrinsic muscle training: a randomized controlled trial
Authors: Kanayama Tomoyuki , Nakase Junsuke , Mochizuki Takafumi , Asai Kazuki , Yoshimizu Rikuto , Kimura Mitsuhiro , Yanatori Yusuke , Kinuya Seigo , Tsuchiya Hiroyuki 
Published: July 2022

Abstract
Foot rock-paper-scissors and towel gathering exercises are widely used for isometric strengthening of the intrinsic foot muscles. We performed an initial trial and reported that foot rock-paper-scissors and towel gathering exercises had effects on the skeletal muscles associated with the medial longitudinal arch and toe pressure force, respectively. However, there are no quantitative reports of interosseous muscle activity after continuous training. Using positron emission tomography, we quantitatively evaluated differences in skeletal muscle activity with these exercises. Eight university student athletes were included in the study (four in the foot rock-paper-scissors group and four in the towel gathering group) and trained for 3 months. They underwent positron emission tomography before and after training. Toe pressure strength and vertical jump were measured. Regions of interest were defined in 25 muscles. The standardized uptake value in the trained limb was compared with that in the non-trained control limb. Foot rock-paper-scissors exercises initially work medially, and with continuation, it affects the intrinsic muscles of the foot, including the lateral longitudinal arch muscles. Continuation of towel gathering exercise improves the toe pressure force and vertical jump. Since these two exercises target different skeletal muscles, it is necessary to train them according to their respective purposes.
Development of a multiplex PCR assay for simultaneous detection of monopartite and bipartite begomoviruses along with associated satellite DNAs
Authors: Sharma Jyoti , Lager Priya , Kumar Yogesh 
Published: July 2022

Abstract
Begomoviral diseases are one of the major factors behind economic losses in agriculturally important crops. Begomoviruses are transmitted by whiteflies (Bemisia tabaci) and are often found to be associated with alphasatellites and betasatellites. Rapid, reliable and early detection methods are invaluable in developing control strategies against these viruses. A multiplex polymerase chain reaction (mPCR) assay was developed for simultaneous detection of monopartite and bipartite begomoviruses along with the associated satellites. Symptomatic leaves of different plant species were used for begomovirus and satellite detection. Primer pairs for each component were designed using reference sequences from GenBank. The primer pairs were designed in such a way that the amplicons differ at least 100bp in size. Amplicons of ~ 185bp, ~ 290bp, ~ 420bp and ~ 685bp were obtained in the mPCR that correspond to betasatellite, DNA-A, alphasatellite and DNA-B respectively. Identities of the viral and satellite components were confirmed by sequencing of the amplicons obtained in mPCR. This mPCR assay can be used for rapid and simultaneous detection of begomovirus genomic components and associated satellites.