bluuebunny/crossref_metadata_2025_split huggingface dataset:
O impacto da insuficiência renal aguda nos pacientes hospitalizados por COVID-19
Authors: Fujimura-Junior Agnaldo Chikitani , Gomes Gabriel Vitor Borges , Urzeda Lara Morgana Martins , Côrtes Letícia Santos Barbosa , Gomes Maria Paula Barbosa Tosta , Abdalla Michel Reis , Abdalla Douglas Reis 
Published: February 2022

Introdução: A insuficiência renal aguda (IRA) é uma súbita redução na função renal com vários fenótipos e representa uma das complicações da infecção pelo novo coronavírus. Há associação multifatorial, entre essas entidades, repercutindo na gravidade do quadro de saúde dos pacientes. Objetivo: O objetivo deste artigo consiste buscar na literatura evidências da lesão renal aguda entre os hospitalizados com a COVID-19 e descrever os aspectos da fenomenologia desta lesão nesta situação. Metodologia: Revisão Sistêmica da literatura nas bases de dados, PubMed, produções realizadas nos últimos 2 anos. Os descritores utilizados foram: “IRA”, “COVID-19”, "SARS-CoV-2", de forma conjugada para delimitação da busca. Resultados: Ao final das etapas selecionaram 15 artigos, sendo 9 do ano de 2020, correspondendo a 60% e 6 de 2021, 40%. Todos esses estudos são do tipo observacional. A IRA é um achado frequente, podendo ser causada pela progressão viral. Há fatores prévios que nos predizem maior risco como hipertensão arterial sistêmica, diabetes mellitus, doença pulmonar obstrutiva crônica. Sabendo disso, o rastreio e acompanhamento da função renal desde a internação é importantíssimo para identificar alterações iniciais passíveis de controle ou reversão, devido aumentar o risco de mortalidade e o uso de corticosteróides, aparentemente, auxiliar a redução desse risco. Plasmaférese e terapias de substituição renal devem ser consideradas. Considerações Finais: Portanto, a evidencia é que o desenvolvimento de IRA nesses casos está relacionado a maior mortalidade, morbidades e terapias de tratamento após alta. Fatores como idade, obesidade e genéticos propiciam a IRA nesses pacientes, gerando repercussões negativas no prognóstico.
PENGARUH KEPEMIMPINAN DAN MOTIVASI TERHADAP KINERJA PEGAWAI PADA KANTOR SEKRETARIAT DPRD KABUPATEN MUNA
Authors: Unsu Farid Ismail , Nasrul Nasrul , Suleman Nursaban Rommy 
Published: February 2022

The purpose of this study were: 1). To know and identifies leadership influence on employee performance on the Parliament Secretariat Muna. 2) the effect of motivation on employee performance. 3) The effect of leadership and motivation on employee performance. The design of the study is a quantitative research. The population in this study were all employees of the Parliament Secretariat Muna totaling 39 people, using saturation sampling withdrawal. Retrieval of data in the form of interviews and questionnaires. The technique of data analysis using multiple regression models with SPSS 24. Research findings show that: 1) Leadership positive and significant effect on employee kineja. 2) Motivation positive and significant effect on employee kineja. 3) Kepempinan and motivation simultaneously positive and significant impact on employee kineja.
PENGARUH PEMAHAMAN SISTEM AKUNTANSI KEUANGAN DAERAH DAN KOMITMEN ORGANISASI TERHADAP KINERJA PENGELOLA KEUANGAN PADA ORGANISASI PERANGKAT DAERAH KABUPATEN MUNA BARAT
Authors: Anto La Ode , Hadisantoso Erwin , Nurdin Sahidin 
Published: February 2022

Penelitian ini bertujuan untuk menguji dan menjelaskan pengaruh pemahaman sistem akuntansi keuangan daerah dan komitmen organisasi terhadap kinerja pengelola keuangan. Sampel pada penelitian ini berjumlah 36 orang pegawai bagian keuangan pada setiap Organisai Perangkat Daerah pemerintah Kabupaten Muna Barat. Metode pengumpulan data menggunakan kuesioner dengan skala Likert. Analisis data menggunakan metode analisis dekskriptif dan analisis linear berganda. Hasil penelitian ini menunjukan bahwa: (1) pemahaman sistem akuntansi keuangan daerah berpengaruh positif dan signifikan terhadap kinerja pengelola keuangan, (2) komitmen organisasi berpengaruh positif dan signifikan terhadap kinerja pengelola keuangan. Hal ini menunjukkan bahwa semakin tinggi tingkat pemahaman sistem akuntansi keuangan daerah dan komitmen organisasi maka kinerja pengelola keuangan akan semakin baik
The Dual Regulation Effects of ESR1/NEDD4L on SLC7A11 in Breast Cancer Under Ionizing Radiation
Authors: Liu Rui , Liu Lin , Bian Yan , Zhang Shinan , Wang Yue , Chen Huajian , Jiang Xinyue , Li Guanghui , Chen Qing , Xue Chang , Li Mengke , Liu Lianchang , Liu Xiaodong , Ma Shumei 
Published: February 2022

Radiotherapy is one of the most important treatments for breast cancer. Ferroptosis is a recently recognized form of regulated cell death that is characterized by lipid peroxidation. However, whether ionizing radiation (IR) could induce ferroptosis in breast cancer and how it works remain unknown. Bioinformatics analysis were performed to screen ferroptosis-related genes differentially expressed in breast tumor tissue and normal tissue. Then, breast cancer cell lines with different estrogen receptor (ER) phenotypes were used for studies in vitro, including ER-positive (MCF-7 and ZR-75-1) and ER-negative (MDA-MB-231) cells. The dynamic changes of mRNA and protein levels were examined after x-ray of 8 Gy by qRT-PCR and Western blotting, respectively. Immunoprecipitation (IP) was used to explore the interaction between proteins. Luciferase assay was used to analyze the transcriptional regulation effect of ESR1 on SLC7A11. BODIPY C11 and trypan blue dyes were used to determine lipid peroxidation and cell death, respectively. The result showed that the ferroptosis-related gene SLC7A11 was higher in breast cancer tissues compared with normal tissues and associated with poor survival. A positive correlation exists between ESR1 and SLC7A11 expression. ESR1 promoted SLC7A11 expression at the early stage after IR. ESR1/SLC7A11 knockdown significantly enhanced IR-induced ferroptosis in ER-positive cells. At 12 h after IR, the IP data showed the interaction between E3 ubiquitin ligase NEDD4L and SLC7A11 increased, followed by the ubiquitylation and degradation of SLC7A11. Thus, SLC7A11 expression was regulated by both ESR1 and NEDD4L, in opposite ways. For the first time, we elucidated that ESR1 and NEDD4L functioned together after radiation treatment and finally induced ferroptosis in breast cancer cells, which provides novel insight into the guidance of clinical treatment of breast cancer.
Clinical- and Cost Effectiveness of a Guided Internet-Based Intervention for Children (12–18 Years) of Parents With Mental Disorders (iCHIMPS): Study Protocol of a Multicentered Cluster-Randomized Controlled Trial
Authors: Dülsen Patrick , Barck Katja , Daubmann Anne , Höller Alexandra , Zeidler Jan , Kilian Reinhold , Wiegand-Grefe Silke , Baumeister Harald 
Published: February 2022

IntroductionChildren of parents with mental disorders have a high chance of developing a mental disorder themselves. However, this at-risk group is regularly overlooked and typically not seen by any mental health professionals. Internet- and mobile-based interventions (IMIs) can provide a means of promoting mental health for children of parents with mental disorders.ObjectiveThe introduced study will evaluate the clinical- and cost-effectiveness of the iCHIMPS IMI in promoting mental health for children of parents with mental disorders.MethodsA two-armed multicentered cluster-randomized controlled trial (cRCT) comparing the clinical- and cost-effectiveness of the iCHIMPS IMI in the intervention group (IG) to a treatment-as-usual (TAU) control group will be conducted. Recruitment will be handled at currently 21 adult mental health clinics throughout Germany. Participating families will be randomly divided into the two groups until the final sample size of 306 participating adolescents (age 12–18) has been reached. The adolescents in the intervention group will receive access to the IMI and can take part in up to eight intervention modules. Assessment will be conducted during the recruitment (baseline), 1-month, 2-months, and 6-month post-inclusion. Primary outcome is the mental health of the participating adolescents at 6-months post-inclusion as measured by the Youth Self Report score. Secondary self-report outcomes are mental wellbeing, self-efficacy, coping strategies and negative effects as well as mental health of the adolescents as reported by their parent(s). Included moderators are sociodemographic characteristics, working alliance, social support and the mental health diagnoses of the parents. Statistical analyses will be conducted on the intention-to-treat principle as well as with additional per-protocol analyses. Additionally, the cost-effectiveness as well as qualitative data concerning the adherence, acceptance, and feasibility of the IMI will be analyzed.DiscussionThe iCHIMPS cRCT examines the clinical- as well as cost-effectiveness of the iCHIMPS mental health promotion IMI for children of parents with mental disorders. This provides the opportunity to gain insights into an innovative as well as time- and location-independent form of support for this often-overlooked at-risk group. Additionally, the larger CHIMPS-NET project allows comparisons between internet-based and face-to-face interventions for a similar target group.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier: DRKS00025158.
Machine Learning for Outcome Prediction in First-Line Surgery of Prolactinomas
Authors: Huber Markus , Luedi Markus M. , Schubert Gerrit A. , Musahl Christian , Tortora Angelo , Frey Janine , Beck Jürgen , Mariani Luigi , Christ Emanuel , Andereggen Lukas 
Published: February 2022

BackgroundFirst-line surgery for prolactinomas has gained increasing acceptance, but the indication still remains controversial. Thus, accurate prediction of unfavorable outcomes after upfront surgery in prolactinoma patients is critical for the triage of therapy and for interdisciplinary decision-making.ObjectiveTo evaluate whether contemporary machine learning (ML) methods can facilitate this crucial prediction task in a large cohort of prolactinoma patients with first-line surgery, we investigated the performance of various classes of supervised classification algorithms. The primary endpoint was ML-applied risk prediction of long-term dopamine agonist (DA) dependency. The secondary outcome was the prediction of the early and long-term control of hyperprolactinemia.MethodsBy jointly examining two independent performance metrics – the area under the receiver operating characteristic (AUROC) and the Matthews correlation coefficient (MCC) – in combination with a stacked super learner, we present a novel perspective on how to assess and compare the discrimination capacity of a set of binary classifiers.ResultsWe demonstrate that for upfront surgery in prolactinoma patients there are not a one-algorithm-fits-all solution in outcome prediction: different algorithms perform best for different time points and different outcomes parameters. In addition, ML classifiers outperform logistic regression in both performance metrics in our cohort when predicting the primary outcome at long-term follow-up and secondary outcome at early follow-up, thus provide an added benefit in risk prediction modeling. In such a setting, the stacking framework of combining the predictions of individual base learners in a so-called super learner offers great potential: the super learner exhibits very good prediction skill for the primary outcome (AUROC: mean 0.9, 95% CI: 0.92 – 1.00; MCC: 0.85, 95% CI: 0.60 – 1.00). In contrast, predicting control of hyperprolactinemia is challenging, in particular in terms of early follow-up (AUROC: 0.69, 95% CI: 0.50 – 0.83) vs. long-term follow-up (AUROC: 0.80, 95% CI: 0.58 – 0.97). It is of clinical importance that baseline prolactin levels are by far the most important outcome predictor at early follow-up, whereas remissions at 30 days dominate the ML prediction skill for DA-dependency over the long-term.ConclusionsThis study highlights the performance benefits of combining a diverse set of classification algorithms to predict the outcome of first-line surgery in prolactinoma patients. We demonstrate the added benefit of considering two performance metrics jointly to assess the discrimination capacity of a diverse set of classifiers.
Identifying and Validating of an Autophagy-Related Gene Signature for the Prediction of Early Relapse in Breast Cancer
Authors: Min Yu , Feng Yang , Luo Haojun , Hu Daixing , Wei Xiaoyuan , He Danshuang , Yin Guobing , Fan Shenghao 
Published: February 2022

BackgroundCompelling evidence has demonstrated the pivotal role of autophagy in the prognosis of breast cancer. Breast cancer (BC) patients with early relapse consistently exhibited worse survival.MethodsThe autophagy-related genes were derived from the Human Autophagy Database (HADb) and high-sequencing data were obtained from The Cancer Genome Atlas (TCGA). Discrepantly expressed autophagy genes (DEAGs) between early relapse and long-term survival groups were performed using the Linear Models for Microarray data (LIMMA) method. Lasso Cox regression analysis was conducted for the selection of the 4-gene autophagy-related gene signature. GSE42568 and GSE21653 databases were enrolled in this study for the external validation of the signature. Then patients were divided into high and low-risk groups based on the specific score formula. GSEA was used to discover the related signaling pathway. The Kaplan-Meier curves and the receiver operating characteristic (ROC) curves were used to evaluate the discrimination and accuracy of the 4-gene signature.ResultsA signature composed of four autophagy-related mRNA including APOL1, HSPA8, SIRT1, and TP73, was identified as significantly associated with the early relapse in BC patients. Time-dependent receiver-operating characteristic at 1 year suggested remarkable accuracy of the signature [area under the curve (AUC = 0.748)]. The risk score model based on the autophagy-related signature showed favorable predicting value in 1-, 2-, and 3-year relapse-free survival (RFS) in training and two validating cohorts. The GSEA displayed gene sets were remarkably enriched in carcinogenic activation pathways and autophagy-related pathways. The nomogram involving three variables (progesterone receptor status, T stage, and 4-gene signature) exhibited relatively good discrimination with a C-index of 0.766.ConclusionsOur study establishes an autophagy-related 4-gene signature that can effectively stratify the high-risk and low-risk BC patients for early relapse. Combined with the clinicopathological variables, the signature could significantly help oncologists tailor more efficient treatment strategies for BC patients.
Perceived Stigma and Self-Efficacy of Patients With Inflammatory Bowel Disease-Related Stoma in China: A Cross-Sectional Study
Authors: Wang Yuting , Li Shuyan , Gong Jianfeng , Cao Lei , Xu Dingting , Yu Qiao , Wang Xiaoying , Chen Yan 
Published: February 2022

BackgroundPatients with inflammatory bowel disease (IBD)-related stoma face physical, psychological, and social adjustment challenges. However, knowledge about stigmatization and self-management, which is important for clinical care and patient education strategies, is lacking.ObjectiveTo evaluate the level of stigma and self-management ability of Chinese patients with IBD-related stoma using an online questionnaire.MethodsParticipants were recruited from two general hospitals in mainland China and the internet platforms of the China Crohn's and Colitis Foundation (CCCF). Participants completed a questionnaire, which gathered data on sociodemographic, clinical, and experience in online groups, self-efficacy scale, and social impact scale. The influencing factors of self-efficacy and perceived stigma were assessed by stepwise multivariate regression analyses.ResultsOne hundred and seventy-six respondents were included. Most of the respondents (78/176, 44.32%) spent between 500 and 999 RMB ($77–153) on ostomy care accessories monthly. Three patients reported using homemade ostomy products. The average score on the self-efficacy scale was 75.79 ± 23.91, which reflected a moderate level of self-efficacy, and 69 (39.2%) respondents had low-level self-efficacy. The average social impact scale score was 62.76 ± 12.69, which reflected a moderate level of perceived stigma. Forty-three (24.43%) patients experienced severe levels of perceived stigma. Stepwise multivariate regression analysis revealed that self-efficacy was associated with educational level (P = 0.007), whereas stigma was associated with nursing privacy (P = 0.021) and acceptance by the closest person (P = 0.005). A total of 91% of respondents who participated in online peer support groups believed the groups were helpful for disease management.ConclusionsChinese patients with IBD-related stoma reported a moderate degree of perceived stigma; their level of self-efficacy was low to moderate. High educational level was associated with high self-efficacy. Notably, acceptance of the stoma by the closest person was an influencing factor protecting patients from perceived stigma. Interventions aimed at improving patient education, reducing economic burden, and strengthening social support should be considered to help improve the living conditions of patients with IBD-related stoma.
4-Methoxydalbergione Inhibits Bladder Cancer Cell Growth via Inducing Autophagy and Inhibiting Akt/ERK Signaling Pathway
Authors: Du Haifang , Tao Ting , Xu Simeng , Xu Changqiong , Li Shan , Su Qiongli , Yan Jing , Liu Bo , Li Ran 
Published: February 2022

Bladder cancer (BC) ranks the fourth in incidence in cancers of men and is a common malignant tumor in women. 4-Methoxydalbergione (4MOD), which is purified from Dalbergia sissoo Roxb, has been shown to have anticancer capacity for osteosarcoma and astroglioma. The role of 4MOD in bladder cancer has not been investigated. This study aims to evaluate the anticancer effect of 4MOD in BC cells and its possible mechanisms. The two human bladder cancer cell lines J82 and UMUC3 were used to evaluate the proliferation inhibitory effect of 4MOD by CCK8 and clonogenic assays. The migratory and invasive ability of tumor cells was examined by scratch test and transwell assay. Apoptosis was detected by flow cytometry and TUNEL assays. The autophagy-related molecules including Beclin-1 and LC3 were examined by Western blotting analysis. Furthermore, the RT-PCR was used to detect the mRNA expression of LC3. 4MOD repressed cell proliferation, migration, invasion and induced cell apoptosis in a concentration-dependent manner. The IC50 values of J82 and UMUC3 were 8.17 and 14.50 μM respectively. The mRNA and protein expression ratio of light chain 3-II (LC3-II)/LC3-I and the protein expression of Beclin-1 were increased when the BC cells were treated with 4MOD. The treatment of 4MOD attenuated the phosphorylation of Akt and ERK in the BC cells. We revealed that the 4MOD inhibits BC cells growth by inducing autophagy and inhibiting Akt/ERK signaling pathway. Our study provides new insights into the mechanism by which 4MOD weakens the proliferation of BC cells. This study demonstrates that 4MOD provided a lead compound for the development of novel compound with potent anticancer effect on BC cells.
Comparative Efficacy of Multiple Therapies for the Treatment of Patients With Subthreshold Depression: A Systematic Review and Network Meta-Analysis
Authors: Jiang Xiumin , Luo Yongxin , Chen Yiwen , Yan Jinglan , Xia Yucen , Yao Lin , Wang Xiaotong , He Su , Wang Feixue , Wang Taiyi , Chen Yongjun 
Published: February 2022

Graphical AbstractGraphical abstract of the network meta-analysis. Note: CES-D, Center for Epidemiologic Studies Depression Scale; BDI, Beck Depression Inventory Scale; PHQ-9, the nine-Item Patient Health Questionnaire; K6, Kessler Screening Scale for Psychological Distress; SUCRA, surface area under the cumulative ranking curves.
Uneven Effects of Sleep Apnea on Semicircular Canals and Otolithic Organs
Authors: Xu Xin-Da , Chen Bin-Jun , Sun An-Rong , Zhang Qing , Cheng Ying , Ren Dong-Dong , Yu Jing , Luo Hui-Ping 
Published: February 2022

ObjectiveThis study aimed to explore how obstructive sleep apnea (OSA) affects the function of each vestibular organ and to identify the correlations among them.MethodsA prospective study was conducted involving 32 healthy controls and 64 patients with OSA. The objective detection methods of the utricle and saccule are vestibular-evoked myogenic potentials (VEMPs). A combination of the caloric test and video head impulse test (vHIT) was used to comprehensively evaluate the objective function of semicircular canals.ResultsElevated thresholds (p &lt; 0.001), decreased waveform amplitudes (p &lt; 0.001), prolonged first wave latencies (p &lt; 0.001), and shortened first interpeak latencies (p &lt; 0.001) were observed in both ocular VEMP (oVEMP) and cervical VEMP (cVEMP). A significant difference was found in the caloric test comparison (χ2 = 4.030, p = 0.045) but not in the vHIT. The intergroup comparison of normal rates among the VEMPs, caloric test, and vHIT groups showed a significant difference (p &lt; 0.001).ConclusionThe impairment of vestibular function in patients with OSA was uneven and biased. More attention should be given to vestibular dysfunction in the diagnosis and treatment of OSA.
Is It Worth It? Obesity Affects Snack Food Valuation Across the Menstrual Cycle
Authors: Heuberger Larissa S. , Gobbi Susanna , Weber Susanna C. , Graf Gwendolyn , Tobler Philippe N. , Asarian Lori , Geary Nori , Roth Mareike , Leeners Brigitte 
Published: February 2022

BackgroundThe importance of menstrual cycle physiology in appetite and obesity is poorly understood. We investigated the effects of body mass index (BMI), menstrual cycle phase and sweet and salty taste on monetary valuation of snack foods.MethodsWe recruited 72 women and after the application of in- and exclusion criteria 31 participants with healthy weight and 25 with obesity remained. The participants completed a willingness to pay (WTP) task to measure subjective value of 30 snack food items in the pre-ovulatory and mid-luteal cycle phases.ResultsGeneralized linear mixed model (GLMM) analysis revealed that BMI, cycle phase and snack taste interacted to influence WTP (−0.15 [−0.22, −0.03], p = 0.002). Hence, WTP was inversely related to BMI, but the strength of the relation depended on cycle phase and taste. The WTP of participants with healthy weight for salty taste changed across cycle phase but the WTP for sweet taste was not affected by cycle phase. Moreover, the cycle effect for the salty snacks ceased in participants with obesity.ConclusionThe inverse effect of BMI on WTP valuation of snack foods contrasts with the positive effect of BMI on pleasantness ratings for milkshakes by the same women that we previously reported. This indicates that the two measures reflect different aspects of food-related valuative processing in obesity. Furthermore, the WTP data suggest that the selection of salty snacks may differ from that of sweet snacks in the pre-ovulatory phase of the menstrual cycle for individuals of healthy weight. The cycle phase does not seem to affect food valuation of participants with obesity. These findings are relevant to understanding and treating obesity in women.