bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathological Significance, Related Molecular Changes and Tumor Immune Response Analysis of the Abnormal SWI/SNF Complex Subunit PBRM1 in Gastric Adenocarcinoma
Authors: Zhou Zhiyi , Huang Dandan , Yang Shudong , Liang Jiabei , Wang Xuan , Rao Qiu 
Published: July 2022

Background: PBRM1 gene abnormalities were recently found to play a role in tumor development and tumor immune activity. This article will explore the clinicopathological and molecular changes and tumor immune activity of the abnormal SWI/SNF complex subunit PBRM1 in gastric adenocarcinoma (GAC) and its significance.Methods: The cBioPortal, LinkedOmics and TISIDB datasets were used to analyze the abnormality of the PBRM1 gene in GAC and its relationship with prognosis, related molecular changes and tumor-infiltrating lymphocytes (TILs). In addition, 198 GAC cases were collected to further study the relationship between the loss/attenuation of PBRM1 expression and clinicopathology, prognosis, microsatellite stability, PD-L1 expression and TIL in GAC. DNA whole-exome sequencing was performed on 7 cases of gastric cancer with loss of PBRM1 expression.Results: The cBioPortal data showed that PBRM1 deletion/mutation accounted for 7.32% of GAC and was significantly associated with several molecular changes, such as molecular subtypes of GAC. The LinkedOmics dataset showed that PBRM1 mutation and its promoter DNA methylation showed lower PBRM1 mRNA expression, and PBRM1 mutation cases showed significantly higher mRNA expression of PD-L1 (CD274). TISIDB data showed that PBRM1 abnormalities were significantly positively associated with multiple TILs. In our group of 198 cases, the loss/attenuation of PBRM1 expression was significantly positively correlated with intra-tumoral tumor infiltrating lymphocytes (iTILs) and deficient MMR and PD-L1 expression. Kaplan–Meier survival analysis showed that the overall survival of GAC patients with loss/attenuation of PBRM1 expression was significantly better (p = 0.023). iTIL was an independent prognostic factor of GAC. Loss of PBRM1 expression often co-occurs with mutations in other SWI/SNF complex subunit genes, and there are some repetitive KEGG signaling changes.Conclusion: Abnormality of the PBRM1 gene may be related to the occurrence of some GACs and can affect tumor immune activity, thereby affecting clinicopathology and prognosis. It may be a potentially effective predictive marker for immunotherapy and a novel therapeutic approach associated with synthetic lethality.
Trifluoromethylated Quinolone-Hydantoin Hybrids: Synthesis and Antibacterial Evaluation
Authors: Mahajan Akhil , Singh Harbinder , Singh Amandeep , Agrawal Devendra K. , Arora Amandeep , Chundawat Tejpal Singh 
Published: July 2022

A series of new trifluoromethyl-substituted quinolones and hydantoin hybrids has been synthesized and evaluated against Gram-positive bacterium (Staphylococcus aureus MTCC 96) and Gram-negative bacteria (Pseudomonas aeruginosa MTCC 441, Klebsiella pneumonia MTCC 109, and Escherichia coli MTCC 442). Compound 19c, having the 6-propene group on the quinolone ring, showed similar activity to a standard drug (chloramphenicol) by exhibiting MIC values of 50 µg/mL against S. aureus and P. aeruginosa. Physicochemical properties of compound 19c were also determined, which were in line with Lipinski’s rule of five, suggesting the suitability of compound 19c in biological systems. Various types of binding interactions of 19c within the active site of DNA gyrase of S. aureus were also streamlined by molecular docking studies, suggesting its capability to block the catalytic process of the DNA gyrase, which could be the possible reason for its antibacterial potential.
All-fiber polarization-maintaining system for noise suppression and signal amplification of picosecond pulses
Authors: Dai Gaoyu , Ozeki Yasuyuki 
Published: July 2022

Abstract
We present an all–fiber polarization-maintaining system, which consists of an ultralow-intensity-noise picosecond Yb mode-locked fiber oscillator, a Yb-doped fiber amplifier and a noise suppressor based on nonlinear optical loop mirror. After amplification and noise suppression, the optical power is as high as 190 mW, and the relative intensity noise (RIN) measured at an optical power of 30 mW is as low as −161.4 dB Hz−1, which is only 0.3 dB higher than the RIN of the oscillator. We also investigated the temperature dependence of the noise suppression performance, which suggests that guided acoustic-wave Brillouin scattering is one of the factors that limit the performance of the noise suppressor.
PENERAPAN MODEL PROJECT BASED LEARNING BERBASIS STEM UNTUK MENINGKATKAN HASIL BELAJAR IPA SISWA SEKOLAH DASAR
Authors: Rahmi Rosita Putri , Meli Nur , Kusdar Kusdar 
Published: July 2022

Sifat-sifat cahaya masih menjadi konsep IPA yang dirasa sulit oleh siswa kelas IV SDN 001 Muara Baadak. Oleh karena itu, Peningkatan hasil belajar IPA melalui model Project Based Learning (PjBL) berbasis STEM merupakan tujuan dari penelitian ini, khususnya terkait materi sifat-sifat cahaya. Subyek penelitian ini adalah siswa kelas IV di SDN 001 Muara Badak tahun pembelajaran 2021/2022 yang berjumlah 20 siswa dengan tiga siklus. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK). Penelitian ini menggunakan teknik tes, observasi dan dokumentasi.Hasil penelitian menunjukkan bahwa rerata nilai hasil belajar siswa pada pra siklus adalah sebesar 52,6 dengan persentase siswa tuntas sebesar 20%. Pada siklus I persentase siswa tuntas sebesar 65% dan terdapat persentase peningkatan sebesar 18,1%. Pada Siklus II persentase siswa tuntas 90% dan terdapat persentase peningkatan sebesar 52,04%. Pada periode akhir siklus III mencapai peningkatan hasil belajar sebesar 71,04%. Dari hasil penelitian dan dapat dsimpulkan bahwa hasil belajar IPA materi sifat-sifat cahaya melalui model Project Based learning Berbasis STEM kelas IV di SDN 001 Muara Badak tahun pembelajaran 2021/2022 mengalami peningkatan.
SOSIALISASI CUCI TANGAN GUNA MENCEGAHPENYEBARAN COVID-19
Authors: Birman Yuliza , Siana Yusti , Jelmila Sri Nani 
Published: July 2022

LatarBelakang: Covid-9 telah menjadi pandemi dunia. Penyakit ini disebabkan oleh virus SarsCov-2 yang ditularkan melalui droplet ataupun kontak langsung dengan virus melalui perantaraan benda atau tangan. Tangan sering menjadi media punularan virus. Untuk itu diperlukan tindakan mencuci tangan dengan langkah-langkah yang benar guna menghilangkan/membunuh virus sehingga penularan dan penyebaran virus dapat dicegah. Belum semua masyarakat mengetahui dan melakukan kegiatan mencuci tangan sesuai langkah dan prosedur yang benar. Untuk itu perlu dilakukan sosialisasi kepada masyarakat mengenai langkah mencuci tangan yang baik dan benar guna mengurarangi penyebaran covid-19.
Metode: Presentasi dan peragaan terhadap pengunjung Puskesmas Air Tawar
Hasil: Kegiatan penyuluhan berjalan lancar dan respon pasien puskesmas peserta PKM cukup baik. Peserta yang hadir berjumlah 24 orang. Tim dosen FK Unbrah yang hadir 6 orang serta mahasiswa yang ikut berpartisipasi berjumlah 30 orang.
Background : Covid-9 has become a global pandemic. This disease is caused by the SarsCov-2 virus which is transmitted through droplets or direct contact with the virus through objects or hands. Hands are often a medium for transmitting the virus. For this reason, it is necessary to wash hands with the right steps to eliminate/kill the virus so that the transmission and spread of the virus can be prevented. Not all people know and carry out hand washing activities according to the correct steps and procedures. For this reason, it is necessary to disseminate information to the public regarding proper and proper hand washing steps to reduce the spread of COVID-19.. Method : Presentation and demonstration to visitors to the Air Tawar Health CenterResult: The outreach activities ran smoothly and the response from the PKM participants was quite good. There were 24 participants in attendance. The team of FK Unbrah lecturers who attended was 6 people and 30 students who participated.
EDUKASI NUTRISI PADA PENYEMBUHAN LUKA POST SECTION CAESAREA
Authors: Saputri Ekawati , Naim Rosani , Rosmiati  , Ma'rifat Nurani , Nurfayanti  , Nursafitri  , Marjan Putri Masyita 
Published: July 2022

Latar Belakang : Persalinan section caesarea merupakan proses kelahiran bayi melalui sayatan pada rahim dan perut. Proporsi persalinan section caesarea di Indonesia tahun 2018 sebesar 17,6 % dengan proporsi tertinggi di provinsi DKI Jakarta (31,1%) dan terendah provinsi Papua (6,7%), sedangkan provinsi Sulawesi Tenggara memiliki proporsi sebesar 7,7%. Salah satu faktor yang mempengaruhi proses penyembuhan luka post section caesarea adalah nutrisi. Tujuan Kegiatan pengabdian ini adalah memberikan edukasi kesehatan tentang nutrisi untuk pemyembuhan luka post section caesarea.
Metode : Pengabdian ini merupakan tindakan rehabilitatif dengan memberikan edukasi nutrisi pada penyembuhan luka post section caesarea.
Hasil : Peserta yang mengikuti edukasi kesehatan berjumlah 19 orang yang terdiri atas ibu-ibu post section caesarea beserta keluarga yang mendampingi. Peserta memahami materi yang diberikan sehingga diharapkan dapat dilakukan di rumah dengan menyiapkan makanan yang mengandung sumber nutrisi untuk penyembuhan luka post section caesarea.
SENAM OTAK UNTUK MENINGKATKAN DAYA INGAT ANAK USIA SEKOLAH
Authors: Andayani Rifka Putri , Ausrianti Rizka , Afnuhazi Ridhyalla 
Published: July 2022

Latar Belakang:
Anak-anak usia sekolah adalah anak-anak yang sedang belajar di sekolah. Anak-anak ini tergolong pada tahap perkembangan akhir masa kanak-kanak sebelum memasuki usia remaja. Senam otak merupakan metode serangkaian latihan berbasis gerakan tubuh sederhana untuk membantu daya ingat anak usia sekolah. Tujuan pengabdian masyarakat ini yaitu untuk meningkatkan daya ingat pada anak usia sekolah.
Metode:
Metode pelaksanaan yaitu dengan melalukan pendidikan Kesehatan dan demonstrasi dengan memperagakan Gerakan senam otak kepada anak usia sekolah yang akan diadakan di Mesjid AL-Mukarahmah pada hari kamis 21 April 2022. Sasaran dalam kegiatan pengabdian masyarakat ini yaitu anak usia sekolah.
Hasil:
Kegiatan pengabdian masyarakat ini dilaksanakan pada hari Kamis tanggal 21 April 2022. Peserta berjumlah 41 orang yang terdiri dari 20 orang siswa laki-laki dan 21 orang siswa perempuan. 85% peserta dapat menjelaskan tentang manfaat senam otak dan mampu menjelaskan kembali tentang cara melakukan senam otak.
What are Singapore parents’ perception of play in the early years?
Authors: Karuppiah Nirmala 
Published: July 2022

International research indicate that play is the most effective way for children to learn and develop physically, cognitively, socially and emotionally as well as reduces stress and enhances confidence, curiosity and creativity. Despite the importance and benefits of play for children’s learning and development, play seems to be vanishing from preschool classrooms globally (and in Singapore) for various reasons. It is believed that one of the reasons for this phenomenon could be the lack of parents’ support for children’s play due to their high expectations and demand for academic achievement and the lack of their awareness or understanding on the importance of play in children’s development. Hence, the key purpose of this exploratory study is to gather data from parents on their perception of play and holistic development in Singapore preschools. Data were collected from 30 parents through interviews using a semi-structured questionnaire. The data collected were transcribed verbatim and coded and subsequently, organised by research question and analysed and interpreted constructively and reflexively. The findings of the study revealed that although most Singapore parents understood and recognised the importance of play and holistic development in the early years, some of them wanted preschools to prepare their children academically for primary school. Parents also shared a list of factors which supported or impeded their support for children’s play and some of them felt that they could benefit from parent education programmes. These findings highlight the importance of the school-family-community partnership in the education of young children in Singapore.
Deriving polarity from granularity
Authors: Goncharov Julie , Wolf Lavi 
Published: July 2022

In this paper, we present a way to unify Positive Polarity Items formed with some NP and minimizers, such as lift a finger. The connection is made via granularity properties of the two classes of polarity sensitive expressions. We begin with an observation in Strawson 1974 that the use of some NP involves an inference about the availability of a more precise identification of NP. Then, we show that the meaning of minimizers can be captured as the mirror image of the same granularity inference. To model our account, we use the granularity system in van Rooij 2011. We propose pragmatic requirements on the use of some NP and minimizers that explain both their granularity inferences and their polarity properties. Finally, we discuss how our proposal can be viewed as reconciliation of referential and alternative-based approaches to polarity.
KESIAPSIAGAAN BENCANA BERBASIS MASYARAKAT MELALUI PENDEKATAN PARTISIPATIF
Authors: Irwan Irwan , Nakoe Moh Rivai 
Published: July 2022

Bencana adalah peristiwa atau rangkaian peristiwa yang mengancam dan mengganggu kehidupan yang disebabkan, baik oleh faktor alam atau faktor non alam maupun faktor manusia sehingga mengakibatkan timbulnya korban jiwa manusia, kerusakan lingkungan, kerugian harta benda, dan dampak psikologis.Program kesiapsiagaan bencana berbasis masyarakat (KBBM) bersifat partisipatif dan merupakan pendekatan lintas-sektoral melalui langkah-langkah mitigasi yang diarahkan pada pengurangan kerentanan fisik, lingkungan, kesehatan dan sosial-ekonomi, serta sebab-sebab yang tidak terduga lainnya.Kegiatan ini merupakan program kesiapsiagaan bencana berbasis masyarakat (KBBM). Tujuan kegiatan untuk melakukan pemberdayaan dan peningkatan kapasitas masyarakat dalam mengambil tindakan inisiatif dan mengurangi dampak bencana yang terjadi di desa tempat tinggalnya. Kegiatan dilaksanakan di Desa Diloato Kecamatan Paguyaman Kabupaten Boalemo kegiatan dilaksanakan selama 7 hari dengan rincian pelaksanaan sosialisasi selama 2 hari, kegiatan pelatihan fokus Group discusion (FGD) selama 3 hari dan pembentukan Forum 2 hari. Kegiatan pelatihan dilaksanakan dengan metode FGD dan pemberian materi dalam bentuk Sosialisasi dan simulasi. Hasil kegiatan pengabdian masyarakat dalam bentuk Pembentukan forum penanggulan bencana desa Diloato beranggotakan 30 orang relawan yang telah dilatih, satu buah dokumen Peta rawan bencana untuk melihat letak- letak rawan bencana yang berada di wilayah desa Diloato. Di dalam peta juga dicantumkan jalur evakuasi dan titik kumpul untuk rawan bencana banjir, satu buah dokumen sistem peringatan dini berupa jalur- jalur evakuasi dan titik kumpul untuk penanggulangan bencana banjir di masing-masing dusun, kegiatan pengabdian masyarakat juga menghasilkan dokumen rencana aksi komunitas, rencana kontigenci bencana alam banjir di tingkat desa Diloato.Kesimpulan perlunya Pembuatan sistim peringatan dini di setiap lokasi yang rawan bencana di tingkat desa yang melibatkan partisipasi masyarakat. Kata kunci : Bencana ; Pemberdayaan Masyarakat ; Kesehatan
PELATIHAN PEMBUATAN PENYARINGAN AIR SEDERHANA UNTUK MEMENUHI KEBUTUHAN AIR BERSIH MASYARAKAT
Authors: Prasetya Ekawaty , Ruhban Andi 
Published: July 2022

ABSTRAK Ketersediaan air bersih sejak dahulu sudah menjadi salah satu ciri kesejahteraan masyarakat. Betapa tidak tanpa ada air bersih tidak mungkin terwujud masyarakat sejahtera, masyarakat yang sehat jasmani dan rohani.Sebagai praktisi kesehatan dalam rangka mendukung visi misi Kementerian Kesehatan Republik Indonesia, sebagai wujud partisipasi dalam mengembangan kesehatan masyarakat, maka dilaksanakan Pengabdian Kolaboratif judul : Pelatihan Pembuatan Penyaringan Air Sederhana Untuk Memenuhi Kebutuhan Air Bersih Masyarakat yang berlokasi di Desa Bulotalangi Timur, Kec. Bulango Timur, Kabupaten Bone Bolango, yang dilaksanakan selama 1 bulan. Tujuan Kegiatan ini untuk dapat memberikan informasi dan pengetahuan kepada masyarakat tentang cara pembuatan penyaringan air sederhana dengan memanfaatkan bahan-bahan alami yang mudah diperoleh disekitarnya agar dapat menjamin ketersediaan air bersih di daerah yang biasanya mengalami kesulitan air bersih akibat bencana banjir mauun pada musim kemarau.Kegiatan ini melibatkan 30 orang peserta. Metode pelaksanaan kegiatan adalah pelatihan bagaimana cara pembuatan penyaringan air sederhana yang bisa digunakan sebagai sumber air bersih bagi keluarga. Hasil Kegiatan pelatihan ini didapatkan dua unit penyaringan air sebagai percontohan, kemudian secara teknis penyaringan air dapat diterima masyarakat karena materialnya mudah didapatkan dan dapat diterima masyarakat. Kata Kunci ; Pelatihan, Penyaringan, air bersih,Kebutuhan Masyarakat ABSTRACT The availability of clean water has always been one of the characteristics of community welfare. How not without clean water it is impossible to create a prosperous society, a society that is physically and mentally healthy. As a health practitioner in order to support the vision and mission of the Ministry of Health of the Republic of Indonesia, as a form of participation in developing public health, a Collaborative Service will be carried out entitled: Training for Making Screening Simple Water to Meet the Clean Water Needs of the Community located in East Bulotalangi Village, Kec. Bulango Timur, Bone Bolango Regency, which was held for 1 month. The purpose of this activity is to be able to provide information and knowledge to the public about how to make simple water filtration by utilizing natural materials that are easily obtained around it in order to ensure the availability of clean water in areas that usually experience water shortages due to floods and dry seasons. It involves 30 participants. The method of implementing the activity is training on how to make a simple water filter that can be used as a source of clean water for families. The results of this training activity resulted in two water filtration units as pilots, then technically the water filtration was acceptable to the community because the materials were easy to obtain and acceptable to the community. Keywords ; Training, Filtering, Clean water, Community Needs
PELATIHAN KADER POSYANDU UNTUK MENINGKATKAN KETERAMPILAN PENGUKURAN ANTROPOMETRI SEBAGAI UPAYA PENCEGAHAN STUNTING DI PUSKESMAS SUKARAJA BANDAR LAMPUNG
Authors: Sari Merry Indah , Angraini Dian Isti , Imantika Efriyan , Oktaria Dwita 
Published: July 2022

Stunting pada balita dapat berakibat pada kesehatan dan kecerdasan anak di masa yang akan datang seperti kerentanan terhadap infeksi dan menurunnya prestasi di sekolah. Kegiatan ini bertujuan untuk melatih kader posyandu dalam meningkatkan keterampilan pengukuran antropometri pada balita. Khalayak sasaran pada kegiatan pengabdian masyarakat ini adalah kader posyandu. Metode yang dilakukan dalam kegiatan ini adalah pemberian materi, pembagian modul pelatihan dan simulasi pengukuran antropometri serta role play. Pengabdian kepada masyarat ini dilakukan pada bulan September 2020. Kegiatan ini dilaksanakan di aula Puskesmas Sukaraja. Hasil pelaksanaan terjadi peningkatan pemahaman kader posyandu dengan pemahaman baik dari 2 % menjadi 82%. Sebanyak 18% kader posyandu masih memiliki pemahaman yang cukup mengenai stunting dan metode pengukuran antropometri. Kesimpulan peningkatan keterampilan kader posyandu dan melakukan KIE mengenai stunting dapat meningkatkan upaya pencegahan stunting.Kata Kunci: antropometri; kader; stunting, kunjungan
POSTPARTUM DEPRESSION PREVENTION CONSOULING IN KUBU RAYA REGENCY, WEST KALIMANTAN
Authors: Sudarto Sudarto , Zakiyya Affi , Handrika Revani 
Published: July 2022

Pasca melahirkan ialah periode dimana seorang ibu akan menjalani hari-hari yang melelahkan dibandingkan dengan masa kehamilan baik fisik maupun psikis yang lebih lanjut akan menimbulkan perasaan stres/depressi. Ibu mengalami stress berlebihan berdampak penurunan minat dan ketertarikan terhadap bayi serta kemampuan merawat bayinya dengan baik, tidak bersemangat menyusui sehingga kesehatan serta tumbuh kembang bayi tidak optimal. Kegiatan pengabdian ini diikuti oleh kader posyandu, pasangan usia subur (PUS), ibu hamil dan ibu pasca melahirkan di Desa Lingga dan Desa Jawa Tengah Kabupaten Kubu Raya, Kalimantan Barat. Tujuan kegiatan untuk meningkatkan pemahaman masyarakat terhadap pencegahan depresi pasca melahirkan, terampil melakukan deteksi terhadap diri dan warganya tentang depresi pasca melahirkan. Sasaran kegiatan ini adalah sejumlah 63 orang. Metode kegiatan dilakukan dua kali dengan dengan memberikan pre test, ceramah dan dilanjutkan post test dengan mengisi kuesioner. Pada evaluasi dilakukan kepada kader dengan melakukan wawancara pemahamannya mengenai pencegahan depresi pasca melahirkan. Adapun hasil yang dicapai pada kegiatan ini adalah Masyarakat di Desa Lingga dan Sui Ambawang memperoleh pengetahuan tentang depresi pasca melahirkan.Kata Kunci: depresi post partum; penyuluhan.Abstract When compared to the physical and psychological stage of pregnancy, which can further induce stress/depression, the post-delivery period is when a mother will have a tiring day. Excessive stress causes mothers to lose interest in their babies, as well as their capacity to properly care for them. They are also less passionate about nursing, resulting in poor baby health, growth, and development. Posyandu cadres, couples of childbearing age (PUS), and postpartum mothers participated in this activity in Lingga Village and Central Java Village, Kubu Raya Regency, West Kalimantan. The goal of the activity is to raise public awareness about postpartum depression prevention, self-detection skills, and citizen awareness about postpartum depression. This activity aims to reach a total of 64 people. The activity was repeated twice, with a pre-test, lecture, and a post-test involving the completion of a questionnaire. The evaluation was conducted on cadres by asking them about their understanding of postpartum depression prevention. The inhabitants of Lingga and Sui Ambawang villages got knowledge about postpartum depression as a consequence of this exercise.Keywords : postpartum depression; consouling.
Mach and Froude Numbers on Mars
Authors: Nasr Camella-Rosa C. , Bradley Mary E. , Lewis Stephen R. , Hollingsworth Jeffery L. , Dowling Timothy E. 
Published: July 2022

Abstract
Mars atmospheric global circulation models exhibit transonic jet streaks during northern winter, which motivates this study of the Mach number, Ma (the ratio of flow speed to the speed of sound), and Froude number, Fr (the ratio of flow speed to the speed of buoyancy waves), as a function of season and location. Two global reanalyses spanning Mars Years (MY) 24 to 32 are used as input, EMARS and OpenMARS. The study’s vertical coordinate is potential temperature, θ, ranging from θ = 400 to 1100 K (from z ≈ 32 to 66 km); the floor is set to the lowest level that avoids intersecting mountains. Area-weighted global means and standard deviations and 5 yr temporal means using the complete years MY 25, 26, 29, 30, and 31 are compared. EMARS and OpenMARS show general agreement below θ = 700 K (z ≈ 53 km), where the observational constraints are strongest, but can vary significantly at higher levels. Both reanalyses contain transonic jet streaks in every northern winter sampled. The Fr signal is roughly twice the Ma number signal, as expected where the temperature lapse rate is small compared to the dry adiabatic lapse rate. Mach numbers are similar in both reanalyses but show larger year-to-year variability in OpenMARS. Maps of standard deviations indicate a depression between the main peaks in Tharsis and higher variability in Mare Boreum than Mare Australe. The main conclusion is that the atmosphere of Mars routinely operates in the compressible regime (0.3 < Ma < 0.8), unlike Earth. Aspects of all flow-speed meteorology are discussed.