bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune Response Studies Based on P2X7 Receptors: A Mini-Review
Authors: Deng Ying , Zhou Mengting , Zhao Xingtao , Xue Xinyan , Liao Li , Wang Jing , Li Yunxia 
Published: February 2022

Abstract:
Inflammation, as a complex immunopathological process, is the organism's natural defense response
against harmful, foreign, and destructive immune or non-immune factors. It is the main pathological form of
various diseases, such as tumors, neurodegenerative diseases, periodontitis, alcoholic steatohepatitis, asthma,
and other diseases. The P2X7 receptor (P2X7R) is widely distributed in vivo and up-regulated in various inflammatory
pathological states. Studies have shown that milder chronic inflammation is related to a deficiency
or inhibition of P2X7R, which is an indispensable part of the pro-inflammatory mechanism in vivo. P2X7R, a
unique subtype of seven purinergic P2X receptors, is an ATP-gated non-selective cationic channel. P2X7R will
promote the influx of Ca2+ and the outflow of K+ after being stimulated. The influx of Ca2+ is essential for activating
the body's innate immune response and inducing the production of inflammatory factors. This paper reviews
the regulation of P2X7R in inflammation from the perspectives of innate immunity and adaptive immunity.
Nanocarriers’- An efficient drug delivery system for neurodegenerative disorders including Alzheimer’s, Parkinson’s, Huntington, Amyotrophic lateral sclerosis and associated risk of nanocarriers, future perspectives - A review
Authors: Ashique Sumel 
Published: February 2022

Abstract:
Various neurodegenerative disorders like Alzheimer’s disease, Parkinson’s disease, Huntington disease, and amyotrophic lateral sclerosis are becoming a major issue in global life. Several treatment options are available, but the major problem of all these approaches is the presence of the highly protective blood-brain barrier (BBB) which limits the possible drug transportation towards CNS. BBB particularly allows some specific components like small sized lipophilic agents through the capillary endothelial membrane. The major challenge to delivering the drug into CNS is the presence of the highly protective BBB; thus, currently, a nanocarrier-based drug delivery system has been approved for an effective and safe approach. This review has depicted a clear view about the route of nanocarrier based drug administration, the reason behind choosing nanocarriers, and what are the several nanocarriers (such as lipoplex, polyplex, nano-micelles, dendrimers, exomes, nanogels, etc) that used to treat the mentioned brain disorders and potential risk, future aspects.
Physical Activity in Patients With Heart Failure During and After COVID-19 Lockdown: Single-Center Observational Retrospective Study
Authors: Brasca Francesco Maria Angelo , Casale Maria Carla , Canevese Fabio Lorenzo , Tortora Giovanni , Pagano Giulia , Botto Giovanni Luca 
Published: February 2022

Background
The COVID-19 pandemic forced several European governments to impose severe lockdown measures. The reduction of physical activity during the lockdown could have been deleterious.

Objective
The aim of this observational, retrospective study was to investigate the effect of the lockdown strategy on the physical activity burden and subsequent reassessment in a group of patients with heart failure who were followed by means of remote monitoring.

Methods
We analyzed remote monitoring transmissions during the 3-month period immediately preceding the lockdown, 69 days of lockdown, and 3-month period after the first lockdown in a cohort of patients with heart failure from a general hospital in Lombardy, Italy. We compared variation of daily physical activity measured by cardiac implantable electrical devices with clinical variables collected in a hospital database.

Results
We enrolled 41 patients with heart failure that sent 176 transmissions. Physical activity decreased during the lockdown period (mean 3.4, SD 1.9 vs mean 2.9, SD 1.8 hours/day; P<.001) but no significant difference was found when comparing the period preceding and following the lockdown (–0.0007 hours/day; P=.99). We found a significant correlation between physical activity reduction during and after the lockdown (R2=0.45, P<.001). The only significant predictor of exercise variation in the postlockdown period was the lockdown to prelockdown physical activity ratio.

Conclusions
An excessive reduction of exercise in patients with heart failure decreased the tolerance to exercise, especially in patients with more comorbidities. Remote monitoring demonstrated exercise reduction, suggesting its potential utility to encourage patients to maintain their usual physical activity levels.
Promoting Resilience and Well-being Through Co-design (The PRIDE Project): Protocol for the Development and Preliminary Evaluation of a Prototype Resilience-Based Intervention for Sexual and Gender Minority Youth
Authors: Lucassen Mathijs F G , Samra Rajvinder , Rimes Katharine A , Brown Katherine E , Wallace Louise M 
Published: February 2022

Background
Sexual and gender minority youth (SGMY) are at an increased risk of a range of mental health problems. However, few evidence-informed interventions have been developed specifically to support their mental well-being. Interventions that are evidence-informed for the general population and are fine-tuned specifically with SGMY in mind proffer considerable potential. A particular opportunity lies in the delivery of engaging interventions on the web, where the focus is on enhancing the coping skills and building the resilience of SGMY, in a way that is directly relevant to their experiences. On the basis of earlier work related to an intervention called Rainbow SPARX (Smart, Positive, Active, Realistic, X-factor thoughts), we seek to create a new resource, especially for SGMY in the United Kingdom.

Objective
This project has 3 main objectives. First, together with SGMY as well as key adult experts, we aim to co-design a media-rich evidence-informed web-based SGMY well-being prototype toolkit aimed at those aged between 13 and 19 years. Second, we will explore how the web-based toolkit can be used within public health systems in the United Kingdom by SGMY and potentially other relevant stakeholders. Third, we aim to conduct a preliminary evaluation of the toolkit, which will inform the design of a future effectiveness study.

Methods
The first objective will be met by conducting the following: approximately 10 interviews with SGMY and 15 interviews with adult experts, a scoping review of studies focused on psychosocial coping strategies for SGMY, and co-design workshops with approximately 20 SGMY, which will inform the creation of the prototype toolkit. The second objective will be met by carrying out interviews with approximately 5 selected adult experts and 10 SGMY to explore how the toolkit can be best used and to determine the parameters and user-generated standards for a future effectiveness trial. The final objective will be met with a small-scale process evaluation, using the think out loud methodology, conducted with approximately 10 SGMY.

Results
The study commenced on September 1, 2021, and data gathering for phase 1 began in October 2021.

Conclusions
A considerable body of work has described the issues faced by the SGMY. However, there is a dearth of research seeking to develop interventions for SGMY so that they can thrive. This project aims to co-design such an intervention.

Trial Registration
Research Registry Reference researchregistry6815; https://www.researchregistry.com/browse-the-registry#home/registrationdetails/609e81bda4a706001c94b63a/

International Registered Report Identifier (IRRID)
PRR1-10.2196/31036
Sistem Pemantauan Jaringan Data Di Stasiun Bumi LAPAN
Authors: Purnomo Purnomo , Nugroho Muazam , Kabes Maria Syenni , Putra Suryo Prakoso , Fathanah Jean 
Published: February 2022

Pusat Teknologi Satelit, Lembaga Penerbangan dan Antariksa Nasional (LAPAN) memiliki beberapa stasiun bumi yang tersebar di beberapa wilayah di Indonesia untuk mendukung pengoperasian satelit LAPAN. Stasiun bumi terletak di Rancabungur, Rumpin, Kototabang (Bukittinggi), Parepare, dan Biak. Semua stasiun bumi terhubung dan dilakukan pengontrolan secara terpusat dari stasiun bumi Rancabungur. Oleh karena itu diperlukan sebuah sistem pemantauan jaringan data yang mampu memonitoring kinerja jaringan setiap saat. Dengan menggunakan metode literatur, dimana penulis mencari beberpa referensi yang relevan dengan kasus-kasus yang ada, maka dibuatlah sistem ini yaitu dengan memanfaatkan paket Internet Control Message Protocol (ICPMP) dan Simple Network Management Protocol (SNMP). ICMP merupakan protokol jaringan internet yang berfungsi untuk memberikan kiriman pesan kedalam sebuah jaringan selama konektivitas. SNMP merupakan protokol dalam jaringan komputer yang dirancang untuk memonitor dan mengatur jaringan dari jarak jauh. Dengan menggunakan SNMP pengguna bisa mendapatkan informasi dan status perangkat jaringan yang digunakan. Dalam bekerja SNMP terdiri dari SNMP manager dan SNMP agent. SNMP manager bekerja untuk mengolah informasi dari perangkat jaringan yang di pantau. SNMP agent merupakan perangkat jaringan yang di monitor kinerjanya. Dalam penelitian ini SNMP digunakan untuk mengambil informasi mengenai memory dan storage dari jaringan stasiun bumi tersebut. Selain memanfaatkan protokol SNMP penulis juga memanfaatkan bot telegram yang digunakan untuk mengirim notifikasi kepada network administrator apabila terjadi gangguan pada jaringan. Sehingga dengan sistem ini kondisi jaringan data stasiun bumi LAPAN lebih mudah untuk dilakukan pemantauan karena network administrator bisa melihat kondisi memory dan storage dari komputer yang digunakan untuk operasi satelit, serta akan mendapatkan pesan melalui telegram apabila terjadi kendala pada jaringan data stasiun bumi LAPAN.
Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies
Authors: Tobi Elmar W. , Juvinao-Quintero Diana L. , Ronkainen Justiina , Ott Raffael , Alfano Rossella , Canouil Mickaël , Geurtsen Madelon L. , Khamis Amna , Küpers Leanne K. , Lim Ives Y. , Perron Patrice , Pesce Giancarlo , Tuhkanen Johanna , Starling Anne P. , Andrew Toby , Binder Elisabeth , Caiazzo Robert , Chan Jerry K.Y. , Gaillard Romy , Gluckman Peter D. , Keikkala Elina , Karnani Neerja , Mustaniemi Sanna , Nawrot Tim S. , Pattou François , Plusquin Michelle , Raverdy Violeta , Tan Kok Hian , Tzala Evangelia , Raikkonen Katri , Winkler Christiane , Ziegler Anette-G. , Annesi-Maesano Isabella , Bouchard Luigi , Chong Yap Seng , Dabelea Dana , Felix Janine F. , Heude Barbara , Jaddoe Vincent W.V. , Lahti Jari , Reimann Brigitte , Vääräsmäki Marja , Bonnefond Amélie , Froguel Philippe , Hummel Sandra , Kajantie Eero , Jarvelin Marjo-Riita , Steegers-Theunissen Regine P.M. , Howe Caitlin G. , Hivert Marie-France , Sebert Sylvain 
Published: February 2022

OBJECTIVEMaternal glycemic dysregulation during pregnancy increases the risk of adverse health outcomes in her offspring, a risk thought to be linearly related to maternal hyperglycemia. It is hypothesized that changes in offspring DNA methylation (DNAm) underline these associations.RESEARCH DESIGN AND METHODSTo address this hypothesis, we conducted fixed-effects meta-analyses of epigenome-wide association study (EWAS) results from eight birth cohorts investigating relationships between cord blood DNAm and fetal exposure to maternal glucose (Nmaximum = 3,503), insulin (Nmaximum = 2,062), and area under the curve of glucose (AUCgluc) following oral glucose tolerance tests (Nmaximum = 1,505). We performed lookup analyses for identified cytosine-guanine dinucleotides (CpGs) in independent observational cohorts to examine associations between DNAm and cardiometabolic traits as well as tissue-specific gene expression.RESULTSGreater maternal AUCgluc was associated with lower cord blood DNAm at neighboring CpGs cg26974062 (β [SE] −0.013 [2.1 × 10−3], P value corrected for false discovery rate [PFDR] = 5.1 × 10−3) and cg02988288 (β [SE]−0.013 [2.3 × 10−3], PFDR = 0.031) in TXNIP. These associations were attenuated in women with GDM. Lower blood DNAm at these two CpGs near TXNIP was associated with multiple metabolic traits later in life, including type 2 diabetes. TXNIP DNAm in liver biopsies was associated with hepatic expression of TXNIP. We observed little evidence of associations between either maternal glucose or insulin and cord blood DNAm.CONCLUSIONSMaternal hyperglycemia, as reflected by AUCgluc, was associated with lower cord blood DNAm at TXNIP. Associations between DNAm at these CpGs and metabolic traits in subsequent lookup analyses suggest that these may be candidate loci to investigate in future causal and mediation analyses.
No More Kidding about iKids
Authors: Cowling Michael 
Published: February 2022

If COVID-19 has taught us anything, it’s that even students born in the 21st century are not quite the digital natives we give them credit for being. Whilst the overarching concept of the digital native as proposed by Prensky in 2001 has been hotly contested for many of its generational assumptions over the last 20 years, it’s clear anecdotally that until recently, many still believed that students of the 21st century are very comfortable with technology and how it is used.
It’s only in the last few years, as the pandemic has forced learning online, that we’ve realized that perhaps students digital skillset might not be what we think it is. What’s more, stories abound of students turning cameras off, or behaving inappropriately in chat, that suggest that the problem is wider than skills, and a more holistic view of what it means to be a digital citizen is needed.
This presentation will take time to understand this trend towards digital citizenship, and what it means for us as scholars of technology enhanced learning. Looking back on past practices, it will make the argument the digital citizenship going forwards need to encompass more than just skills and needs to be more holistic in focus. In doing so, we can really understand how we might construct our curriculum into the future.
First, this presentation will break down the way we’ve traditionally thought about digital skills (Sturgess, Cowling, & Gray, 2016). Building on recent research, it will help understand what competencies need consideration in this space going forward, and how skills such as social networking or messaging might translate into our classroom.
It will then discuss screen time, and how students approach this aspect of digital citizenship (Orlando, 2021). Rather than talking about banning technology and removing it from classrooms, we will discuss how technology can be used to enhance the classroom experience, whilst also ensuring that students do not get addicted to using it inappropriately. Thoughts on how best to build balanced digital citizens will also be shared.
Concepts of digital safety will also be discussed (Walsh & Pink, 2021), and how this idea compares to our traditional ideas of student safety. Work by the Australian Federal government on cyber safety will be visited to understand how we might enhance this concept with a more holistic mindset.
Finally, student self-control will be touched on (Cowling, 2015). Students of the 21st century face a venerable plethora of possible resources that they can access, with little in the way of age restrictions, or clear indicators of their quality. We will discuss fake news and information overload, understanding how these concepts might fit into the broader narrative.
Through interrogating each of these ‘four S’s’: Skills; Screen Time; Safety; and Self-Control, we will propose a new way to look at the digital native that will set a trend going forward, moving us from digital natives to a clearer, more specific model that suits the iKids emerging out of the post-COVID world.
Wpływ sposobów regulacji zachwaszczenia na plon i wybrane parametry jakościowe ziarna pszenicy twardej (Triticum durum Desf.) i zwyczajnej (Triticum aestivum L.)
Authors: DYŃSKA MONIKA , HALINIARZ MAŁGORZATA , KAPELUSZNY JAN 
Published: February 2022

W latach 2003–2005 badano plonowanie i jakość ziarna dwóch linii pszenicy twardej (długosłomej i ościstej LGR 1359/8 i bezostnej o krótkiej słomie LGR 899/17A) w porównaniu z odmianą Helia pszenicy zwyczajnej, w zależności od sposobu regulacji zachwaszczenia. Doświadczenie założono metodą split-plot w trzech powtórzeniach, na glebie brunatnej wytworzonej z lessu w Zakładzie Doświadczalnym w Czesławicach (Płaskowyż Nałęczowski). W doświadczeniu porównywano sześć sposobów regulacji zachwaszczenia, tj. mechaniczny, mechaniczno-chemiczny i mechaniczny, z zastosowaniem pełnej i obniżonej dawki herbicydu Chwastox Trio 540 SL (300 g·l-1 mekoprop + 200 g·l-1 MCPA + 40 g·l-1 dicamba), w terminie optymalnym i opóźnionym, z obiektem kontrolnym nieodchwaszczanym. Plon ziarna pszenicy twardej był przeciętnie w wieloleciu o 28,7% niższy w porównaniu z plonem pszenicy zwyczajnej. Zawartość białka ogólnego i ilość glutenu mokrego w ziarnie pszenicy twardej były zadowalające jedynie w roku 2003 o korzystnym przebiegu pogody. Lepszą jakością charakteryzował się jednak gluten pszenicy zwyczajnej. Herbicyd zastosowany w obniżonej dawce, podobnie jak w dawce zalecanej, nie pogorszył badanych cech. Natomiast bronowanie połączone z herbicydem, jak i sam zabieg bronowania, oddziaływały gorzej na plon ziarna w porównaniu z metodą chemiczną.
PENGARUH E_PRODUCT QUALITY, E_SERVICE QUALITY, E_INNOVATION, E_PRICE DAN E_STORE IMAGE TERHADAP E_PURCHASE INTENTION SOCIOLLA
Authors: Lestari Ririn Ari Dwi , Dewi Citra Kusuma 
Published: February 2022

E-commerce (electronic commerce) saat ini sedang digandrungi oleh para pecinta online shopping. Secara sederhana e-commerce dapat dijelaskan sebagai proses pembelian maupun penjualan produk secara elektronik. karena semakin berkembangnya e-commerce beberapa tahun belakangan ini secara bertahap e-commerce dapat menggantikan toko tradisional atau offline. monthly active user (MAU) e-commerce memperoleh hasil tertinggi yang mencapai 137 juta pengguna setiap bulan. kemudian hasil riset menyebutkan pengguna e-commerce di Indonesia didominasi oleh perempuan. Sementara itu produk Kecantikan menempati peringkat ke tiga sebagai produk paling laris dijual di e-commerce, Oleh karena itu produk kecantikan menjadi salah satu kategori produk yang digemari oleh pengguna e-commerce. Penelitian ini bertujuan untuk mengetahui pengaruh pengaruh e_product quality, e_service quality, e_innovation, e_price dan e_store image terhadap e_purchase intention Sociolla. Pengumpulan data pada penelitian ini melalui penyebaran kuesioner dan menggunakan analisis data kuantitatif. Pengambilan sampel dilakukan dengan metode non- probability sampling yaitu dengan teknik purposive sampling. Sampel yang digunakan dalam penelitian ini sebanyak 100 responden. Metode analisis yang digunakan pada penelitian ini adalah uji Analisis Regresi Berganda dan Alat analisis yang digunakan dengan bantuan SPSS versi 25. Berdasarkan hasil penelitian dari analisis deskriptif menunjukkan bahwa variabel e_product quality, e_service quality, e_price dan e_store image termasuk kedalam kategori baik, lalu variabel , e_innovation termasuk kedalam kategori Sangat baik, sedangkan e_purchase intention termasuk kedalam kategori cukup baik . Hasil analisis regresi linear berganda dapat disimpulkan bahwa e_product quality, e_service quality, e_innovation, e_price dan e_store image berpengaruh positif dan signifikan terhadap e_purchase intention Sociolla baik secara parsial maupun simultan. Berdasarkan hasil uji koefisien determinasi diperoleh nilai sebesar 95,5%. Hal ini berarti hubungan antar variabel independen dengan variabel dependen sebesar 95,8%.Kata kunci : e_product quality, e_service quality, e_innovation, e_price, e_store image, e_purchase intention
PENGARUH MOTIVASI DAN LINGKUNGAN KERJA TERHADAP KINERJA KARYAWAN PADA CV INDAH BARU GROUP GENTENG
Authors: Oktadilah Sofia , Syarifuddin Syarifuddin 
Published: February 2022

Penelitian ini dilatarbelakangi oleh hasil data primer yang menyatakan bahwa motivasi dan lingkungan kerja karyawan pada CV Indah Baru kurang optimal. Perusahaan menginginkan kinerjanya meningkat setiap tahun agar dapat menang dalam menghadapi persaingan, oleh sebab itu kinerja karyawan menjadi perhatian karena akan mempengaruhi kinerja perusahaan.Tujuan penelitian ini guna untuk mengetahui pengaruh motivasi dan lingkungan kerja terhadap kinerja karyawan di CV Indah Baru Group.
Penelitian ini menerapkan metode kuantitatif deskriptif. Populasi pada penelitian ini adalah seluruh karyawan tetap CV Indah Baru Group yang terdiri dari 73 orang dengan menggunakan sampling jenuh. Analisis data yang digunakan yakni analisis deskriptif, uji asumsi klasik serta analisis regresi berganda.
Berdasarkan hasil analisis deskriptif motivasi termasuk ke dalam kategori baik dan juga untuk lingkungan kerja termasuk ke dalam kategori baik sedangkan untuk kinerja karyawan sama dalam kategori baik. Berdasarkan hasil penelitian menunjukkan bawa motivasi dan lingkungan kerja berpengaruh secara parsial dan isimultan terhadap kinerja karyawan sebesar 61,6% sedangkan sisanya 38,4% dipengaruhi oleh faktor lain yang tidak diteliti pada penelitian ini
Katı Çiftlik Gübresine Farklı Kimyevi Gübre İlavesinin Bazı Besin Elementlerinin Suda Çözünürlüğü Üzerine Etkisi
Authors: ÖNER Nureddin , ÖNER Filiz 
Published: February 2022

Laboratuvar koşullarında saksılarda yapılan bu araştırma üç tekerrürlü olarak yürütülmüştür. Fermente olmamış hayvan dışkılarına ve hayvanların altına serilen yataklıktan oluşan katı taze büyükbaş katı çiftlik gübresine kontrol, %5, %10, %20 ve %40 olmak üzere beş farklı oranda 15-15-15-Zn gübresi, 20-20-0+Zn gübresi, DAP gübresi (18-46), MAP (12-61-0) ve Üre (46-0-0) gübresi uygulanmıştır. Uygulanan kimyevi gübrenin homojen olması için öğütülmüş sonrada orijinal nemiyle katı çiftlik gübresine ilave edilmiş, iyice karıştırıldıktan sonra ilk hafta günde iki defa daha sonraki günlerde 2 günde bir defa olacak şekilde karıştırılarak oksijenli fermantasyona tabi tutulmuştur. Oksijenli fermantasyon için çok önemli olan ve %50-60 düzeyinde olması gereken nem miktarı için her saksı tartılarak saf su ilave edilmiştir. Fermantasyona tabi tutulan organik gübre + kimyevi gübre karışımından 2. ve 60. günlerde örnekler alınarak suda çözünebilir fosfor (P), kalsiyum (Ca), magnezyum (Mg), sodyum (Na), bakır (Cu), demir (Fe), mangan (Mn) ve çinko (Zn) elementleri içeriğine etkisi belirlenmiştir.
Araştırma sonuçlarına göre fermente olmamış katı taze katı çiftlik gübresine %5, %10, %20 ve %40 oranda ilave edilen 15-15-15-Zn, 20-20-0+Zn, DAP (18-46), MAP (12-61-0) ve Üre (46-0-0) ilavesinden sonra katı çiftlik gübresinde suda çözünebilir fosfor (P), kalsiyum (Ca), magnezyum (Mg), sodyum (Na), bakır (Cu), demir (Fe), mangan (Mn) ve çinko (Zn) elementleri miktarı üzerine etkisi zaman (2. ve 60. gün), gübre dozu (kontrol, %5, %10, %20 ve %40) ve zaman x gübre dozu interaksiyonu p