bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep Learning for Acute Myeloid Leukemia Diagnosis
Authors: Nazari Elham ,   Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Farzin Amir Hossein ,   Department of Computer Engineering, Khayyam University, Mashhad, Iran, Aghemiri Mehran ,   Department of Medical Informatics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran, Avan Amir ,   Molecular Medicine Group, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Tara Mahmood ,   Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Tabesh Hamed ,   Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,   Hamed Tabesh Department of Medical Informatics, Faculty of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran Phone: +98 51 38002536;Fax: +98 51 38002445. E-mail: Tabeshh@mums.ac.Ir
Published: November 2022

By changing the lifestyle and increasing the cancer incidence, accurate diagnosis becomes a significant medical action. Today, DNA microarray is widely used in cancer diagnosis and screening since it is able to measure gene expression levels. Analyzing them by using common statistical methods is not suitable because of the high gene expression data dimensions. So, this study aims to use new techniques to diagnose acute myeloid leukemia.
In this study, the leukemia microarray gene data, contenting 22283 genes, was extracted from the Gene Expression Omnibus repository. Initial preprocessing was applied by using a normalization test and principal component analysis in Python. Then DNNs neural network designed and implemented to the data and finally results cross-validated by classifiers.
The normalization test was significant (P>0.05) and the results show the PCA gene segregation potential and independence of cancer and healthy cells. The results accuracy for single-layer neural network and DNNs deep learning network with three hidden layers are 63.33 and 96.67, respectively.
Using new methods such as deep learning can improve diagnosis accuracy and performance compared to the old methods. It is recommended to use these methods in cancer diagnosis and effective gene selection in various types of cancer.
Does CT Reduce the Rate of Negative Laparoscopies for Acute Appendicitis? A Single-Center Retrospective Study
Authors: Pedro Wagner De J. ,   Department of Surgery, Naas General Hospital, Naas, Ireland, Haroon Muthana ,   Department of Surgery, Naas General Hospital, Naas, Ireland, Morarasu Stefan ,   Department of Surgery, Naas General Hospital, Naas, Ireland,   Stefan Morarasu MD, PhD Student Naas General Hospital Craddockstown Rd, Naas East, Naas, Co. Kildare, W91 AE76, Ireland. Phone number: +353858760635 E-mail: morarasu.stefan@gmail.com, Eguare Emmanuel ,   Department of Surgery, Naas General Hospital, Naas, Ireland,   Trinity College, Dublin, Ireland, Al-Sahaf Osama ,   Department of Surgery, Naas General Hospital, Naas, Ireland,   Trinity College, Dublin, Ireland
Published: November 2022

In surgical practice, surgeons request CT scans to rule out acute appendicitis, even in young patients. We aimed to assess the feasibility of using a CT scan to reduce the rate of negative laparoscopies in patients younger than 40 with equivocal signs of acute appendicitis.
Therefore, we conducted a retrospective observational study on the patients admitted with a provisional diagnosis of acute appendicitis. Patients younger than 40 and with the Alvarado score between 3 and 6 were included. These were divided into two groups: those who had or did not have a CT scan. Each group was further subdivided into patients that had a laparoscopy and those that did not.
Out of 204 patients included in the study, 16% were included in the CT group, and 84% in the non-CT group. 71.9% of the patients that underwent a CT scan had appendicitis and underwent an appendectomy. Five patients with a normal CT scan had appendectomy due to persistent signs of acute appendicitis. The histopathology of the 23 patients with positive CT was positive, and 3 of the 5 patients with negative CT that underwent appendectomy had positive histology results. The negative appendectomy rate for patients that had preoperative CT is 7.14% compared to 32.4% in patients without preoperative CT.
The rate of negative laparoscopy in patients younger than 40 years old that undergo preoperative CT is significantly lower with a p-value of .00667.
Protective Effect of Vitamin C and Zinc as an Antioxidant Against Chemotherapy-Induced Male Reproductive Toxicity
Authors: Hajjar Toktam ,   Department of Biology, Faculty of Sciences, Hakim Sabzevari University, Sabzevar, Iran., Soleymani Foroogh ,   Department of Biology, Faculty of Sciences, Hakim Sabzevari University, Sabzevar, Iran., Vatanchian Mehran ,   Department of Anatomical Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.,   Mehran Vatanchian, Department of Anatomical Sciences, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran. E-mail: vatanchianm921@mums.ac.ir, mvatanchian@gmail.com
Published: November 2022

Treatment with anticancer drugs such as cyclophosphamide can harm the male reproductive system. Vitamin C and zinc are micronutrients with antioxidant activity and are the essential components of semen. Therefore, this study aimed to evaluate whether cyclophosphamide-exposed mice can recover from fertility with vitamin C and zinc therapy.In this experimental study, fifty male mice were divided into five groups. Groups 1-4 received cyclophosphamide (100 mg/kg, once a week for eight weeks). Also, group 2 received zinc (200 mg/kg), group 3 received vitamin C (300 mg/kg), group 4 received zinc and vitamin C (200 mg/kg and 300 mg/kg, respectively), five times per week for eight weeks, and group 5 received normal saline once a week and water five days a week for eight weeks. The data collected were statistically analyzed using SPSS 22.Results showed a significant increase in mount latency and a significant decrease in the number of sperms in the cyclophosphamide group compared to the control group. However, mount latency has been significantly decreased in mice treated with cyclophosphamide plus zinc compared to the cyclophosphamide group. The study also showed that the sperm count in the group that received cyclophosphamide and zinc had been increased compared to the cyclophosphamide group; the other treatments have decreased mount latency and increased the sperm count compared to the group treated with cyclophosphamide but not significantly. The Tubule Differentiation Index showed an increase in the cyclophosphamide-Zinc-Vitamin C group in comparison with the cyclophosphamide group.The current study showed that zinc could improve cyclophosphamide-induced toxicity of the reproductive system in male mice.
Performance Evaluation on Rotary Preparation of Root Canal by Beginner Operators
Authors: Chirila Mihaela ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Suciu Ioana ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Ioana Suciu,Department of Endodontics, Faculty of Dentistry,„Carol Davila” University of Medicine and Pharmacy, Bucharest. E-mail: ioana.suciu@umfcd.ro, Dimitriu Bogdan ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Maru Nicoleta ,   Department of Clinical Anatomy and Topography, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Ionescu Ecaterina ,   Department of Orthodontics and Dento-Facial Orthopedics, Faculty of Dental Medicine,“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Croitoru Georgiana Florentina ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Amza Oana ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: November 2022

This study aims to analyze the performance of rotary root canal preparation, conducted by beginner operators (students). After acquiring the necessary skills involved in applying endodontic preparation techniques on extracted teeth, all students from a cohort learned to use ProTaper Universal files (Dentsply Maillefer). The preclinical training had several stages. Experience 1: instrumentation on extracted single-root teeth; Experience 2: instrumentation on EndoTraining blocks (Dentsply Maillefer); Experience 3: instrumentation on EndoTraining blocks (Dia Dent Group International); Experience 4: Instrumentation on extracted multiradicular teeth. Preparation was done according to the manufacturer’s instructions, the initial file is Sx, followed by S1, S2, F1, F2 and the last file is F3. A batch of 50 teeth (E1, E2, E3, E4) was randomly selected to evaluate the onset of the rotary preparation of young operators. Two independent evaluators analyzed the array radiologically by stereomicroscope evaluation (E1, E4) and photo-analysis of the resulting Endo Training blocks (E2, E3). The success rate was 80% for E1, 72% for E2, 64% for E3 and 76% for E4 (p<0.05). The following were considered a failure: ledge formation and apical transportation in 10.66%, over instrumentation in 6.66%, zipping in 3.33%, and instrument fracture in 4% of cases.
Endodontic instrumentation techniques require training to acquire the necessary skills. Rotary root canal instrumentation techniques used almost exclusively in modern endodontics require adequate preclinical training.
Impact of inpatient rehabilitation on quality of life among stroke patients
Authors: Khanna Meeka , Sivadas Dhinla , Gupta Anupam , Haldar Partha , Prakash Navin B. 
Published: November 2022

Objective:
Despite remarkable progression in the treatment of stroke, the life quality and social related events caused by stroke have received limited attention in our country. Quality of life (QOL) assessment is an important part of the evaluation of stroke patients and their management. The objective of this study was to assess QOL in patients with stroke at the time of admission in rehabilitation unit and to assess the impact of inpatient rehabilitation on change in QOL in these patients.

Materials and Methods:
Adult patients with first arterial stroke of any duration, with presentation as hemiplegia, were recruited. The clinical outcome scales and 36-Item Short Form Health Survey (SF-36) parameters for QOL were assessed at both admission and discharge. The scales used were Scandinavian stroke scale (SSS), Barthel Index (BI), and modified Rankin Scale. SF-36 scores were assessed after 6 weeks of discharge also.

Results:
Ten patients with median age of 36.5 years and median duration of stroke 75 days were recruited. There was significant improvement in functional scores of BI and SSS scales at the time of discharge. Majority of the components of both physical and mental domains of QOL SF-36 questionnaire showed significant improvement. The QOL scores after 6 weeks of discharge did not show significant change except for the emotional well-being.

Conclusion:
The QOL in patients with stroke improves with inpatient rehabilitation along with motor and functional scores. Improved functional independence leads to better emotional state after discharge also.
Development and internal validation of a nomogram to predict massive blood transfusions in neurosurgical operations
Authors: Sungkaro Kanisorn , Taweesomboonyat Chin , Kaewborisutsakul Anukoon 
Published: November 2022

Objectives:
A massive blood transfusion (MBT) is an unexpected event that may impact mortality. Neurosurgical operations are a major operation involving the vital structures and risk to bleeding. The aims of the present research were (1) to develop a nomogram to predict MBT and (2) to estimate the association between MBT and mortality in neurosurgical operations.

Material and Method:
We conducted a retrospective cohort study including 3660 patients who had undergone neurosurgical operations. Univariate and multivariate logistic regression analyses were used to test the association between clinical factors, pre-operative hematological laboratories, and MBT. A nomogram was developed based on the independent predictors.

Results:
The predictive model comprised five predictors as follows: Age group, traumatic brain injury, craniectomy operation, pre-operative hematocrit, and pre-operative international normalized ratio and the good calibration were observed in the predictive model. The concordance statistic index was 0.703. Therefore, the optimism-corrected c-index values of cross-validation and bootstrapping were 0.703 and 0.703, respectively.

Conclusion:
MBT is an unexpectedly fatal event that should be considered for appropriate preparation blood components. Further, this nomogram can be implemented for allocation in limited-resource situations in the future.
Awake brain surgery for autistic patients: Is it possible?
Authors: Drosos Evangelos , Maye Helen , Youshani Amir Saam , Ehsan Sheeba , Burnand Cally , D’Urso Pietro Ivo 
Published: November 2022

Background:
Awake neurosurgery is currently the mainstay for eloquent brain lesions. Opting for an awake operation is affected by a number of patient-related factors. We present a case of a patient with autistic spectrum disorder (ASD) that was successfully operated for a brain tumor through awake craniotomy. To the best of our knowledge, this is the first reported case in the literature.

Case Description:
A 42-year-old patient, with known ASD since his childhood, underwent awake craniotomy for a left supplementary motor area tumor. Detailed preoperative preparation of the patient was done to identify special requirements and establish a good patient-team relationship. Intraoperatively, continuous language and motor testing were performed. Conversation and music were the main distractors used. Throughout the operation, the patient remained calm and cooperative, even during a focal seizure. Mapping allowed for >80% resection of the tumor. Postoperatively, the patient recovered without any deficits.

Conclusion:
This case shows that with growing experience and meticulous preparation, the limits of awake craniotomy can be expanded to include more patients that were previously considered unfit.
Development of posttraumatic frontal brain abscess in association with an orbital roof fracture and odontogenic abscess: A case report
Authors: Abdulrazeq Hael , Walek Konrad , Sampath Shailen , Shaaya Elias , Beqiri Dardan , Woo Albert , Sampath Prakash 
Published: November 2022

Background:
Brain abscess is a potentially fatal condition. Orbital fractures caused by penetrating injury may be associated with intracranial infection. Such complication associated with blunt trauma, orbital roof fractures, and odontogenic abscesses is exceedingly rare.

Case Description:
We report the case of a 40-year-old transgender female with a frontal abscess presenting several weeks following a motor vehicle crash from which she suffered multiple facial fractures and an odontogenic abscess. On computed tomography scan, the patient had multiple right-sided facial fractures, including a medial orbital wall fracture and a right sphenoid fracture extending into the superior orbital roof. There was hemorrhage notable in the right frontal lobe. Communication with the ethmoid sinuses likely provided a conduit for bacterial spread through the orbit and into the intracranial and subdural spaces.

Conclusion:
Skull base fractures that communicate with a sinus, whether it be frontal, ethmoid, or sphenoid may increase the risk of brain abscess, especially in patients who develop an odontogenic abscess. Surgical repair of the defect is essential, and treating patients prophylactically with antibiotics may be beneficial.
The role of the guarantee industry in strengthening MSMEs in indonesia during pandemic Covid 19
Authors: Vikaliana Resista , Arifin Antoni Ludfi , Latunreng Wahyuddin , Bari Abdul 
Published: November 2022

Credit guarantees carried out by banks with the Credit Guarantee Agency in this case are the Indonesian Credit Guarantee Corporation (PT Jamkrindo) and PT (Persero) Indonesian Credit Insurance (PT Askrindo) such as a guarantee mechanism so that if there is a transfer of bad credit risk. This study aims to identify the role of guarantor institutions in strengthening MSMEs in Indonesia during the COVID-19 Pandemic. This study uses qualitative methods, and the data analysis technique used is content analysis. the study of content with reference to the meaning, context, and intent contained in the message. Results Based on the research, it appears that credit guarantees for MSMEs from guarantee institutions encourage the effectiveness of credit guarantees. The role of guarantee institutions for MSMEs in credit guarantees can be more effective if the institutions carry out the development of business partners and implement the integration or digitization of IT systems. During the pandemic, Jamkrindo contributed to the Working Capital Credit Guarantee (KMK) program in the National Economic Recovery (PEN) and mentoring MSMEs.
Perbandingan rate of returns to education di perguruan tinggi negeri dan swasta
Authors: Noor Sri Tubilah 
Published: November 2022

<span lang="EN-US">Penelitian ini ditujukan untuk mengetahui kelayakan dan tingkat pengembalian investasi pendidikan alumni Prodi Hukum Unpad dan Unisba. Pendekatan Penelitian yang digunakan adalah kuantitatif, dengan metoda peneltian deskriptif-komparatif menggunakan teknik pengambilan sampel total sampling. Sumber data dalam penelitian adalah data primer dan data sekunder. Teknik pengumpulan data menggunakan angket, wawancara , observasi dan dokumentasi. Data yang terkumpul kemudian dihitung dan dianalisis menggunakan analisis deskriptif dan analisis tingkat pengembalian investasi atau <em>rate of return on invesment</em>. Adapun metode perhitungan yang digunakan dalam analisis <em>rate of return </em>adalah <em>Net Present Value(NPV</em>) atau <em>Discounted Cash Flow, Internal rate of return </em>(IRR) dan Uji Perbandingan Dua Rata-Rata Sample Independent Sample Test (T-test). Hasil penelitian ini menunjukkan, bahwa investasi yang dilakukan alumni di Prodi Hukum dapat dikatakan layak. Di samping itu, Perbandingan antara Prodi hukum Unpad dan Uninus tingkat pengembalian investasi alumni berbeda berdasarkan masa studi dan lamanya bekerja.</span>
Dampak Peggunaan Media Sosial Terhadap Kesehatan Mental Dan Kesejahteraan Sosial Remaja Dimasa Pandemi Covid-19
Authors: Septiana Nila Zaimatus 
Published: November 2022

Di masa pandemi jumlah penggunaan media sosial bagi anak-anak dan remaja meningkat, dan peningkatan tersebut menimbulkan dampak positif maupun negatif. Penelitian ini betujuan untuk mencari pengaruh antara penggunaan media sosial terhadap kesehatan mental dan kesejahteraan sosial bagi remaja dimasa pandemi covid-19. Responden penelitian ini sebanyak 257 orang berusia sekitar 12 hingga 19 tahun. Penelitian ini menggunakan pendekatan kuantitatif dengan desain ekplanatori. Analisis data dalam penelitian ini menggunakan analisis regresi linier sederhana dan analisis MANOVA. Hasi penelitian menunjukkan terdapat pengaruh antara penggunaan media sosial terhadap kesehatan mental dan kesejahteraan sosial remaja dimasa pandemi covid-19.
Ekomodernistiset aluesuunnittelun ympäristödiskurssit Pohjois-Karjalassa
Authors: Mustonen Anna 
Published: November 2022

Artikkelissa tarkastellaan alueellisen maankäytönsuunnittelun ympäristödiskursseja Pohjois-Karjalassa. Keskityn erityisesti globaalien ilmastonmuutoksen hillinnän ja luonnon monimuotoisuuden suojelun tavoitteiden toteutukseen maakuntasuunnittelussa. Tutkimuksessa analysoin sisällönanalyysin ja diskurssianalyysin keinoin aineistoon kuuluvat maakuntastrategian, kolme maakuntaohjelmaa sekä kokonaismaakuntakaavan ympäristövaikutusten arviointeineen. Tässä kriittisessä aluesuunnittelun ympäristöpoliittisessa tutkimuksessa sovelletaan evolutionaarisen hallinnan teoriaa. Tutkimus valaisee keskeiset poliittishallinnolliset syyt heikkoon ympäristötavoitteiden toteutukseen maankäytön suunnittelussa aluetasolla Pohjois-Karjalassa. Tutkimuksessa väitetään, että syynä tähän ovat aluekehittämisen riippuvuussuhteet ja Euroopan Unionin ympäristöpolitiikasta lähtöisin olevat ja aluesuunnittelussa omaksutut ekomodernistisen ympäristöpolitiikan hallinnan mallit.
Love’s Imperfection
Authors: Mattingly Cheryl 
Published: November 2022

This paper concerns friendship as an aspect of family love and its fragilities. I explore love as an on-going ethical demand and problem in family life, one that can present continual obstacles to the ability to continue as a family. I also look at intra-family friendship as a means for addressing such threats. Drawing upon long-term fieldwork among African American families caring for children with chronic illnesses and disabilities (Mattingly 2010a), I explore a situation faced by one of these families when a household accident badly injures one of the children. Although I examine a family rupture, I part company with the widely held view in anthropology that the properly moral (or ethical) needs to be radically contrasted with the ordinary. Rather, I argue that the ordinary can provide resources for what Stanley Cavell calls ‘moral transcendence’.
Keywords: ethics, anthropology of morality, Cavell, kinship, love, friendship,moral psychology
PENYULUHAN PERIKANAN BIOAKUAPONIK : INTEGRASI SISTEM AKUAKULTUR BERTEKNOLOGI BIOFLOK DENGAN SISTEM HIDROPONIK
Authors: Mumpuni Fia Sri , Muarif  , Marhaly Mulyana , Wahyudin Yudi , Lesmana Dudi , Farasfatih Ekorini , Yulianti Nani 
Published: November 2022

The purpose of this community service activity is to transfer knowledge about the application and use of bioquaponic technology which is the integration of biofloc technology and hydroponic systems. The target of this community service activity is ornamental fish cultivators and the general public in Ciomas District, Bogor Regency. The activity was carried out in December 2021. The method of community service activities carried out was the lecture method, discussion and demonstration of direct practice in the field. The results of this community service activity in Ciomas Subdistrict, Bogor Regency, show that there is a transfer of knowledge regarding the integration of bioaquaponics, biofloc technology, hydroponic systems, fish disease management, business development and group dynamics as well as demonstrations of the application and use of bioaquaponics. Based on the results of the pre-test and post-test conducted before and after community service, there was an increase in the capacity and capability of the representation of ornamental fish cultivators, which increased by 50 percent on average. The ornamental fish farming business actors who represent the cultivating community in this activity also get new networks to strengthen the collaboration of the ornamental fish cultivator community, business people and universities. Thus, the expected output of activities in community service in Ciomas District, Bogor Regency, namely (i) an increase in knowledge of ornamental fish farmers regarding the integration of aquaculture systems with biofloc technology and aquaponics systems, (ii) increasing the quality and quantity of ornamental fish production, and (iii) an increase in the network of ornamental fish cultivators in Ciomas District, Bogor Regency, can be achieved.