bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fully integrated, all-stretchable epidermal electronics with digital electrochromic display for rapid electrochemical sensing
Authors: Yin Lu , Cao Mengzhu , Kim Kyeong Nam , Lin Muyang , Sempionatto Juliane , Yu Jialu , Moon Jong-Min , Trifonov Alexander , Zhang Fangyu , Hu Hongjie , Go Jaekung , Xu Sheng , Wang Joseph 
Published: February 2022

Abstract
The lack of compact integration, including fusing of skin-interfaced direct, rapid independent data visualization along with light, safe stretchable batteries, hinders progress towards the creation of fully autonomous comprehensive wearable monitoring platforms. Here we present a highly integrated epidermal sensing platform combining electrochemical sensors with stretchable battery and ultra-low power digital display that instantaneously visualizes the results via 10 individually addressable electrochromic pixels. The all-around stretchable patch can operate independently as a standalone device to directly display the concentration of various electrolytes or metabolites, freeing it from any wired or wireless connection to other equipment. Fabricated via high-throughput printing of customized elastomeric inks, the integrated system presents robust mechanical performance, enduring over 1500 stretching cycles without affecting its sensing and display capabilities. The fast-responding display exhibits stability over 10,000 ON/OFF cycles, and upon coupling with the high-performance stretchable battery, can serve 14,000 sensing sessions in a week-long usage. Merging ultra-low power consumption, independent operation, rapid data display and superior mechanical performance, this fully autonomous multifunctional self-sustainable wearable sensing platform is of high practicality and convenience for diverse practical applications in professional sports, personalized wellness management, and beyond.
Alleviation of phytotoxic effect of heavy metals on wheat by multiple heavy metal tolerant Pseudomonas aeruginosa HMT 7
Authors: Sen Monica , JOSHI HARSHADA 
Published: February 2022

Abstract
Heavy metal pollution in soils and water bodies is becoming a serious threat to environment and is a matter of wide concern. This study was carried out on soil bacterial strain isolated from heavy metal contaminated soil collected from Zawar, Udaipur (India) with the aim of exploring the impacts of land use on heavy metal contamination of soil and sediment. A total of 23 zinc tolerant isolates were recovered on nutrient agar supplemented with 1 mM concentration of zinc sulphate heptahydrate. Out of which isolate HMT 7 which showed highest MIC of 31 mg/ml was further characterized by morphological, cultural, biochemical and molecular characterization and was identified as Pseudomonas aeruginosa HMT 7. The isolate showed multiple heavy metal tolerance and grew in presence of zinc sulphate heptahydrate (30 mg/ml), cadmium chloride (100 µg/ml) and lead nitrate (100 µg/ml). The heavy metal accumulation by the isolate was also evidenced by transmission electron microscopy. A pot experiment under heavy metal stress conditions was performed using Triticum aestivum L. as a test crop. Heavy metal toxicity reduced various plant growth parameters; however, inoculation of Pseudomonas aeruginosa HMT 7 alleviated the heavy metal toxicity and enhanced the plant growth parameters.
Children’s Adherence to Antiretroviral Therapy and Associated Factors: Multi-center Cross-sectional Study
Authors: Gemechu Getahun B. , Habtamu J , Zarihun K 
Published: February 2022

Abstract
Background- Sub- optimal adherence to antiretroviral therapy will lead drug resistance, treatment failure, clinical deterioration, death and failure to thrive in children. Studies conducted among children below 15 years old were limited in Ethiopia in general and in study area in particular. Therefore, this study was aimed to assess status of children’s adherence to ART and associated factors in study area.Methods- We conduct a facility-based cross-sectional study by including total of 282 children <15 years, who received Anti retro viral therapy for at least one month. All children/caregivers who were attending ART clinic during data collection period were consecutively recruited to the study. Both bivariate and multivariate logistic regression were performed.Result- Out of 282 caregivers included with their children, 226(80.2%) were females (mean age= 38.6 and SD = 12.35) and out of the total children, half (50%) were female and 246(87.2%) were between the ages 5–14 years (mean age= 8.5 and SD = 2.64). Two hundred forty six (87.2%) children had adherence status of ≥95% in the month prior to interview. Children whose caregivers were residing in urban were 3.3 (95% CI: 1.17, 9.63) times more adherent to ART than those whose caregivers were residing in rural. Children whose caregivers were biological parent were 2.37(95% CI: 1.59, 3.3) times more adherent than those whose caregivers were non biological parent. Also children of caregivers who were knowledgeable about ART treatment, were 4.5(95% CI: 1.79, 9.8) times more adherent to ART than their counter partsConclusion and recommendation- Adherence status of children in our study area was comparable. Being biological caregivers, residing in urban and knowledgeable about ART treatment were facilitate adherence to ART. Ongoing education about treatment and further study with multiple adherence assessment method were recommended.
Comparison of Anterior or Posterior Approach in Surgical Treatment of Thoracic and Lumbar Tuberculosis: a Retrospective Case-control Study
Authors: Qiu Jincheng , Liang Anjing , Qiu Xianjian , Gao Wenjie , Liang Tongzhou , Zhu Yuanxin , Chen Taiqiu , Hu Wenjun , Gao Bo , Deng Zhihuai , Peng Yan , Huang Dongsheng 
Published: February 2022

Abstract
Background: With the widespread use of the posterior surgery, more and more surgeons chose posterior surgery to treat thoracic and lumbar tuberculosis. But others still believed that the anterior surgery is more conducive to eradicating the lesions, and easier to place larger bone pieces for bone graft fusion. We compared the clinical and radiological outcomes of anterior and posterior surgical approaches and presented our views.Methods: This study included 52 thoracic and lumbar tuberculosis patients at Sun Yat-sen Memorial Hospital from January 2010 to June 2018. All cases underwent radical debridement, nerve decompression, intervertebral bone graft fusion and internal fixation. Cases were divided into anterior group (24 cases) and posterior group (28 cases). Statistical analysis was used to compare the clinical effectiveness, radiological outcomes, complications and other related information.Results: Patients in the anterior group and the posterior group were followed up for an average of 27.4 and 22.3 months, respectively. There were no statistically significant differences between groups in the preoperative, postoperative and last follow-up VAS score, ASIA grade and Cobb angle of local kyphosis. Moreover, there were no statistically significant differences in the improvement of neurological function, loss of kyphotic correction, total incidence of complications, operative time, intraoperative blood loss and hospital stay between the two groups (P>0.05). But there was greater correction of kyphosis, earlier bone fusion, lower incidence of poor wound healing, less interference with the normal spine and less internal fixation consumables and medical cost in the anterior group (P<0.05).Conclusions: Both anterior and posterior approaches are feasible for thoracic and lumbar tuberculosis. However, the anterior approach has greater advantages in kyphotic correction, bone fusion, wound healing, protection of the normal spine, and medical consumables and cost.
Evaluating research co-production: Protocol for the Research Quality Plus for Co-Production (RQ+ 4 Co-Pro) Framework
Authors: McLean Robert K.D. , Carden Fred , Graham Ian D. , Aiken Alice B. , Armstrong Rebecca , Bray Judy , Cassidy Christine E. , Daub Olivia , Ruggiero Erica Di , Fierro Leslie A. , Gagnon Michelle , Hutchinson Alison M. , Kislov Roman , Kothari Anita , Kreindler Sara , McCutcheon Chris , Reszel Jessica , Scarrow Gayle 
Published: February 2022

Abstract
BackgroundResearch co-production is an umbrella term used to describe research users and researchers working together to generate knowledge. Research co-production is used to create knowledge that is relevant to current challenges and to increase uptake of that knowledge into practice, programs, products, and/or policy. Yet, rigorous theories and methods to assess the quality of co-production are limited. Here we describe a framework for assessing the quality of research co-production – Research Quality Plus for Co-Production (RQ+ 4 Co-Pro) – and outline our field test of this approach.MethodsUsing a co-production approach, we aim to field test the relevance and utility of the RQ+ 4 Co-Pro framework. To do so we will recruit participants who have led research co-production projects from the international Integrated Knowledge Translation Research Network. We aim to sample 16 to 20 co-production project leads, assign these participants to dyadic groups (8 to 10 dyads), train each participant in the RQ+ 4 Co-Pro framework using deliberative workshops and oversee a simulation assessment exercise using RQ+ 4 Co-Pro within dyadic groups. To study this experience, we use a qualitative design to collect participant demographic information and project demographic information, and will use in-depth semi-structured interviews to collect data related to the experience each participant has using the RQ+ 4 Co-Pro framework.DiscussionThis study will yield knowledge about a new way to assess research co-production. Specifically, it will address the relevance and utility of using RQ+ 4 Co-Pro, a framework that includes context as an inseparable component of research, identifies dimensions of quality matched to the aims of co-production, and applies a systematic and transferable evaluative method for reaching conclusions. This is a needed area of innovation for research co-production to reach its full potential. The findings may benefit co-producers interested in understanding the quality of their work, but also other stewards of research co-production. Accordingly, we undertake this study as a co-production team representing multiple perspectives from across the research enterprise, such as: funders, journal editors, university administrators, and government and health organization leaders.
Machine Learning based Recommender Systems for Crop Selection: A Systematic Literature Review
Authors: OMMANE Younes , RHANBOURI Mohamed Amine , CHOUIKH Hicham , JBENE Mourad , CHAIRI Ikram 
Published: February 2022

Abstract
Crop selection (CS) is one of the most critical elements that affects the final yield directly. As a result, selecting an appropriate crop is always a critical decision that a farmer must make, considering environmental factors. Choosing an appropriate crop for a given farm is a difficult decision including a plethora of variables that influence the final yield. Experts are frequently consulted to assist farmers with CS; but, as this alternative is time consuming and expensive, it is not available to many farms. The use of recommender systems (RSs) in agricultural management has recently brought some captivating and promising results. We propose a systematic literature review (SLR) in this article to find and provide the most relevant and high-quality publications ad- dressing the crop recommendation (CR) question. The core concept of this SLR is inspired from the guidelines of PRISMA 2020.The different CR approaches are discussed, as well as all the most important input features for recommendation, which are determined and classified. We also identified some of the biggest hurdles to using CR in agriculture. Besides, we made an inventory of the most used techniques for CR. Further, we made an inventory of evaluation criteria and evaluation approaches.
Silicon-based plasmonic photodetector in the near-infrared region with a Schottky barrier properly controlled by nanoalloys
Authors: Okamoto Shinya , Kusada Kohei , Nomura Yuki , Takeda Eiji , Inada Yasuhisa , Hisada Kazuya , Anada Satoshi , Yamamoto Kazuo , Hirasawa Taku , Kitagawa Hiroshi 
Published: February 2022

Abstract
Plasmonic Schottky devices have attracted considerable attention for use in practical applications based on photoelectric conversion because they enable to harvest light below the bandgap of semiconductors. In particular, silicon (Si)-based plasmonic Schottky devices have great potential for useful photodetection in the near-infrared region. However, the internal quantum efficiency (IQE) values of previously reported devices have been low because the Schottky barrier is excessively high. Here, we are the first to develop AuAg nanoalloy–n-type Si plasmonic Schottky devices by cathodic arc plasma deposition. These plasmonic nanostructures can be fabricated in only ~1 min. The fabricated AuAg nanoparticles-film structure enables proper control of the Schottky barrier height and increases the area of the Schottky interface for electron transfer. As a result, the considerably enhanced IQE of our device at 1310 nm (1550 nm) is 4.6 (6.5) times higher than those in previous reports, and these responsivities are a record high.
Prevalence and Factors Associated With Psychological Distress Among Patients on Anticoagulation With Warfarin at the Uganda Heart Institute, Mulago Hospital
Authors: Naisanga Molly , Sekaggya-Wiltshire Christine , Muhwezi Wilson Winstons , Akena Dickens 
Published: February 2022

Abstract
Introduction: Cardio vascular diseases (CVD) are the leading cause of mortality worldwide, and are significantly associated with multiple cormobid disorders including mental disorders. At increased risk of psychological distress (PD) is the sub-category of patients that not only require chronic therapy but the need for follow up with continuous blood tests and dose adjustments (like the patients on warfarin). A number of factors have been shown to be associated with PD including factors which are a direct result of the underlying CVD, those resulting from issues pertaining to therapy and also other wider determinants of PD. However, not much has been done to ascertain the burden of PD among patients on warfarin in Uganda.Objective: The objective of this study was to determine the prevalence and factors associated with PD among patients on anticoagulation with warfarin at the Uganda Heart Institute (UHI).Methods: In this descriptive cross-sectional study, 197 participants were sampled from adults on warfarin attending the Uganda Heart Institute (UHI) out patient clinic.The Self Reporting Questionnaire (SRQ-20) was used to assess the patients for PD, and a socio-demographic questionnaire to document the socio-demographic characteristics of the subjects. Additional questions including the underlying CVD diagnosis, medications used (besides warfarin) and presence of chronic illnesess were also assessed. Frequencies and proportions were used to describe the sample characteristics. Bi-variable and multi-variabe analysis techniques were used to examine the associations between the dependent and independent variables.Results: The prevalence of PD was 32%. The unemployed participants were 4.5 times more likely to have PD (aOR 4.56 [1.12-18.62]p=0.04). Participants who had experienced social stressors were more likely to have PD (aOR11.38 [3.60-36.04]p<0.01). A shorter length of time on warfarin was associated with PD (aOR 0.03 [0.07-0.74]p=0.04). Presence of other chronic comorbidities was associated with PD (aOR 3.69 [1.24-11.02]p=0.02) as well as concomitant use of loop diuretics (aOR 4.13 [1.67-10.19]p<0.01). Conclusion: The prevalence of PD was high among patients on warfarin in this low income setting and there is a need to characterize the specific psychiatric disorders in patients with CVD. Interventions that address the high burden of PD are urgently needed in this setting.
Relationship Between Serial Lactate Testing and Clinical Outcome of Critically Ill Patients With Sepsis
Authors: Zhang Bing , Li Gongke , Wang Yurong , Li Yong 
Published: February 2022

Abstract
Objective Our study was to investigate the relationship between serial lactate testing (SLT) and the clinical outcome of critically ill patients with sepsis. Materials and Methods This was a retrospective cohort study. We extracted the clinical data of patients with sepsis from the Medical Information Mart for Intensive Care version III, 1.4 database. Kaplan-Meier survival curves and multivariate logistic regression models were used to predict the relationship between clinical indicators and 28-day mortality. Receiver operating characteristic curves (ROCs) were used to analyze the impact of the maximum, minimum, and initial values of lactate on 28-day mortality; calculate the Youden index to take the best cutoff value; and then perform a subgroup analysis. Results In total, 2367 patients with sepsis were enrolled, including 1961 in the SLT group and 406 in the non-SLT group. Clinical indicators seemed to be more serious in the SLT group than in the non-SLT group. ROC analysis results showed that the initial value, maximum value and minimum value of blood lactate had a significant impact on the 28-day mortality of patients, P<0.001; multivariate logistic regression analysis indicated that SLT had a negative impact on 28-day mortality [OR=2.03, 95% CI (1.67, 3.60)], p<0.05.Conclusion We found that SLT was correlated with sepsis severity but might not improve the clinical outcome of critically ill patients with sepsis. Clinicians should pay attention to differential diagnosis of the source of lactate elevation; our study results need randomized controlled trials for further verification.
Quality of Sea-ice Habitat Traversed by Antarctic Krill Larvae Influences Recruitment Success
Authors: Veytia Devi , Bestley Sophie , Meiners Klaus , Kawaguchi So , Murphy Eugene , Kusahara Kazuya , Corney Stuart 
Published: February 2022

Abstract
Antarctic krill are a key Southern Ocean species whose success is attributed to their adaption to the extreme polar seasonality. Overwinter sea-ice presence and characteristics exert a strong control on larval survival and subsequent recruitment. Our understanding of the mechanisms through which sea ice influences survival are mainly underpinned by small-scale observations, whereas planktonic larvae may be advected over large scales. Using a state-of-the-art sea-ice model we computed Lagrangian back-trajectories to simulate larval krill advection into three distinct recruitment regions and examined modelled sea-ice habitat characteristics along trajectories. From these results we identify potential overwintering habitats and present a conceptual model for explaining regional variability in sea-ice habitat drivers of recruitment. Crucially, many of these sea-ice habitats are currently under-sampled. This work can inform future sampling efforts that will improve our understanding of climate change impacts, and potential interactions with the krill fishery.
Principles of SecA-driven cotranslational translocation
Authors: Zhu Zikun , Wang Shuai , Shan Shu-ou 
Published: February 2022

Abstract
SecA, an ATPase known to posttranslationally translocate secretory proteins across the bacterial plasma membrane, also binds ribosomes, but the role of SecA’s ribosome interaction has been unclear. Here, we used a combination of ribosome profiling methods to investigate the cotranslational actions of SecA. Our data reveal the widespread accumulation of large periplasmic loops of inner membrane proteins in the cytoplasm during their cotranslational translocation, which are specifically recognized and resolved by SecA in coordination with the proton motive force (PMF). Furthermore, SecA associates with 25% of secretory proteins with highly hydrophobic signal sequences at an early stage of translation and mediates their cotranslational transport. In contrast, the chaperone trigger factor (TF) delays SecA engagement on secretory proteins with weakly hydrophobic signal sequences, thus enforcing a posttranslational mode of their translocation. Our results elucidate the principles of SecA-driven cotranslational protein translocation and reveal a hierarchical network of protein export pathways in bacteria.
Correlation analysis of circulating myeloma cells with tumor load, angiogenesis and disease progression of multiple myeloma and clinical significance
Authors: Tan Ran , Liu Yuke , Pu Qiyao , Li Jiwei , Cao Xueyan , Yue Baohong 
Published: February 2022

Abstract
Objective to investigate the correlation between the phenotype and number of circulating myeloma cells (CMCs) and the load of marrow myeloma cells (MMCs) in patients with multiple myeloma (MM) and the relationship between CMCs and MM prognostic indicators, and to evaluate the feasibility of CMCs reflecting the load of myeloma cells, angiogenesis and disease progression. 109 confirmed MM patients were selected and divided into newly diagnosed and relapse (ND/RA) group (n=53), partial remission (PR) group (n=30) and complete remission (CR) group (n= 23) according to diagnosis and efficacy criteria. Thirty anemia patients with non-plasma cell related diseases in our hospital were selected as control group. Flow cytometry was used to detect the proportion and phenotype of CMCs and MMCs in each group. The prognostic indicators of MM patients were analyzed, including hemoglobin (Hb), plasma albumin (Alb), beta2-microglobulin (β2-MG), serum creatinine (sCrea), serum calcium (Ca), lactate dehydrogenase (LDH), bone destruction, renal impairment, Durie-Salmon stage and International Staging System stage. There was a positive correlation between CMCs and MMCs in ND/RA and PR groups (P<0.05); The proportions of MMCs and CMCs in ND/RA group were significantly higher than those in PR, CR and control groups (P < 0.05). The expression rate of cytoplasmic vascular endothelial growth factor(cyVEGF) in CMCs was significantly higher than that in circulating plasma cells. Therefore, we concluded that CMCs can reflect tumor load, angiogenesis and disease progression in MM patients. Detection of CMCs improves patient compliance compared to MMCs.
Recent advances of metal nanowire based transparent conductive electrodes for flexible chromatic devices
Authors: Huang Shengyun , Liu Yannan , Yang Fan , Wang Yong , Yu Ting , Ma Dongling 
Published: February 2022

Abstract
Transparent conductive electrodes (TCEs) that can maintain structure integrity and remain highly electrically conductive under large mechanical deformations are strongly desired and urgently needed in flexible optoelectronics. Nevertheless, the TCE technology in flexible electronics remains at a standstill, in which brittle indium tin oxide (ITO) is main material being used. Metal nanowires (NWs) networks with high optoelectronic performance as next-generation TCEs have widespread applications in flexible electronics, such as smart windows, touch panels, solar cells and flat displays. Here we review the latest advances that have been made for metal NWs TCEs, including the strategies for the synthesis of metal NWs, metal NWs films assembly via different solution-based processes and their practical applications as electrodes in various flexible chromic devices, as well as discuss their challenges and perspectives for the future practice.