bluuebunny/crossref_metadata_2025_split huggingface dataset:
Who stop telemonitoring disease activity and who adhere: a prospective cohort study of patients with inflammatory arthritis
Authors: Wiegel J. , Seppen B. F. , Nurmohamed M. T. , Bos W. H. , ter Wee M. M. 
Published: November 2022

Abstract
Background
The use of frequent electronic patient reported outcome measures (ePRO’s) enables monitoring disease activity at a distance (telemonitoring) in patients with inflammatory arthritis. However, telemonitoring studies report declining long-term adherence to reporting ePRO’s, which may oppose the benefits of telemonitoring. Therefore, the objective was to investigate what factors are associated with (non-)adherence to telemonitoring with a weekly ePRO in patients with inflammatory arthritis (IA).

Methods
We performed a prospective cohort study in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) at Reade Amsterdam, The Netherlands. Patients telemonitored their disease activity weekly for 6 months with a modified Multidimensional Health Assessment Questionnaire completed in a smartphone application. The primary outcome was time to dropout, defined as ≥ 4 weeks of consecutively nonresponse. Based on literature and through expert meetings, a predefined set of 13 baseline factors were selected to assess the association with time to dropout through a multivariable Cox-regression analysis.

Results
A total of 220 consecutive patients were included (mean age 54, SD 12; 55% females; 99 RA, 81 PsA, and 40 AS). A total of 141 patients (64%) dropped out, with a median time to dropout of 17 weeks (IQR 9–26). Women had a significant higher chance to dropout over 6 months compared to men (HR 1.58, 95% CI 1.06–2.36).

Conclusion
In the set of investigated factors, women stopped reporting the weekly ePRO sooner than men. Future focus group discussions will be performed to investigate the reasons for dropout, and in specific why women dropped out sooner.
Trial registration This trials was prospectively registered at www.trialregister.nl (NL8414).
Polysaccharide composition during cotton seed fibre development: temporal differences between species and in different seasons
Authors: Pettolino Filomena A. , Yulia Dina , Bacic Antony , Llewellyn Danny J. 
Published: November 2022

AbstractBackgroundCotton seed fibres are long single-celled epidermal trichomes that first appear on the surface of the ovule at anthesis and then elongate rapidly over a period of 15–25 days until a secondary cell wall (SCW) begins to develop through a rapid increase in the deposition of microfibrillar cellulose between the plasma membrane and the primary cell wall that eventually terminates elongation. Quantitative measurements of the different polysaccharide components in both wall types over time and how they influence fibre quality can direct studies involved in enhancing fibre properties for yarn quality through cell wall manipulation or molecular breeding.ResultsA detailed chemical analysis of cell wall composition by differential solvent fractionation was used to identify the range of polysaccharides present in mature cotton fibres and used to validate a simpler total cell wall monosaccharide linkage analysis protocol for wall compositional analysis. Analysis of fibres from 5 days post-anthesis through maturity for three cultivated species,Gossypium hirsutum,G. barbadense, andG. arboreum, showed the dynamic nature of cell wall polysaccharide composition through fibre development and that it progressed differently for each species. Plants grown in the glasshouse during either autumn to winter or spring to summer and within each species had fibre qualities and temporal aspects of cell wall development that were different for each season. Notably, the timing of the deposition of the SCW was delayed in winter grown plants and appeared to influence key fibre quality properties.ConclusionsThese results suggest that the temporal aspects of cell wall polysaccharide biogenesis during fibre development influence final fibre quality, and this timing is determined by both genetic and environmental factors. The onset of SCW synthesis appears to be a critical factor coinciding with termination of fibre elongation and specifying the duration of wall thickening that then affects fibre length and other wall-associated quality parameters that ultimately determine yarn quality.
Computed tomographic features of pulmonary pure ground-glass nodule: a comparison between neoplastic and non-neoplastic nodules
Authors: Hafez Mona Ahmed Fouad , Elgaml Arwa Mohammed Abdulbaset Emam , Khairy Mostafa Ahmed , El Hinnawy Yasmine Hamdy , Abd-Elmageed Mohammed Raafat 
Published: November 2022

Abstract
Background
Ground-glass nodules (GGNs) are detected more frequently nowadays with the increase in MDCT resolution and applications. On CT GGN is a well circumscribed nodule with mild increase attenuation and not obscuring bronchial and vascular markings. This study aimed to discriminate neoplastic from non-neoplastic pure ground-glass nodules (pGGNs) by performing comparative quantitative and qualitative assessment of main features in computed tomography (CT) chest imaging. This prospective study involved 72 patients, who were referred to perform multidetector computed tomography of the chest in the radiology department. Cases with ground-glass pulmonary nodules were included in the study, and each nodule was assessed and followed for 2 years by a radiomics software for density and histogram analysis and then classified to neoplastic and non-neoplastic nodules. Neoplastic and non-neoplastic nodules morphology and radiomics were compared, and statistical analysis was done.

Results
After histopathology, positron emission tomography and computed tomography, or close follow-up, pGGNs were classified to neoplastic and non-neoplastic nodules. There was statistically significant difference regarding the mean size, where in cases of neoplastic nodules it was 6.66 mm and the mean size of benign nodules was 11.25 mm. Moreover, irregularity index and histogram peak frequency had a significant correlation with a P value of 0.007 and 0.022, respectively. The cutoff level for peak frequency percentage was 20.5% with 56.3% sensitivity and 79.2% specificity.

Conclusions
Radiomics had a growing role in pulmonary nodule assessment. Radiomics along with morphologic features assessment improved the detection efficiency of neoplastic versus non-neoplastic ground-glass nodules with histogram peak frequency, nodule size, and irregularity index as the main differentiating factors in this study.
Insulinoma Presenting With Postprandial Hypoglycemia in a Pregnant Woman With MEN-1
Authors: Wood Anna J , Kasireddy Vidya , Chitturi Sridhar , Walsh John P 
Published: November 2022

Abstract
Insulinomas are rare insulin-secreting tumors of pancreatic origin that cause hypoglycemia and can be associated with multiple endocrine neoplasia type 1 (MEN1). While rare, they are the most common cause of hypoglycemia related to endogenous hyperinsulinism. A 28-year-old woman with known MEN1 presented with postprandial hypoglycemia in the second trimester of pregnancy. Prior to her presentation she was known to have several pancreatic neuroendocrine tumors that had been stable on serial imaging, but no history of hypoglycemia. She was managed with dietary intervention during pregnancy and gave birth to a healthy baby at 37 weeks’ gestation. After pregnancy, hypoglycemia initially resolved, but then recurred at 8 months post partum. Magnetic resonance imaging showed several pancreatic neoplasms with the largest lesion measuring 29 mm in the pancreatic tail, unchanged from previous imaging. After localization with a selective arterial calcium stimulation test, the patient underwent successful distal pancreatectomy with resolution of symptoms. This case is unusual in that her initial presentation was during pregnancy, she had predominantly postprandial rather than fasting hypoglycemia, and her symptoms remitted for several months after delivery. Key learning points are to have a low index of suspicion for an insulinoma when there is a history of MEN1 and the need for a pragmatic approach to diagnosis and treatment during pregnancy.
Isomorphic (Koebner) Phenomenon Induced by Insulin Analogue Injections in Psoriasis
Authors: Thijs Saartje , Balti Eric , Degraeve Corinne , Coremans Peter 
Published: November 2022

Abstract
Koebner phenomenon is an uncommon skin-related complication of subcutaneous insulin injection in patients with diabetes mellitus. This reaction, also referred as isomorphic phenomenon, has previously been described in various conditions including vitiligo, lichen planus, and psoriasis. We report a 56-year-old woman insulin-treated patient with type 2 diabetes mellitus who developed new-onset, sharply well-demarcated erythematous scaly plaques at the insulin injection sites consistent with Koebner phenomenon. These lesions occurred after withdrawal of methotrexate initiated for the treatment of psoriasis. The lesions responded well to guselkumab, an interleukin-23 targeting agent but not ciclosporin. Of note, unlike previously reported cases, our patient developed isomorphic response under treatment with insulin analogues and during psoriasis flare-up. This case highlights the paramount role of thorough and cautious examination of injection and insertion sites in patients at risk undergoing subcutaneous continuous glucose monitoring or treated with continuous transdermal/subcutaneous insulin injections.
Shanzhai: Creative Imitation of China in Highland Myanmar
Authors: Steinmüller Hans 
Published: November 2022

Abstract
The Wa State of Myanmar is often called “shanzhai China,” that is, a lesser imitation of China. This essay unpacks the material and symbolic implications of creative imitation at the Chinese periphery, embodied in shanzhai 山寨 practices. Literally “mountain fortress,” shanzhai refers to the provenience of cheap brand imitations, made by mountain dwellers who cannot afford the original. The term is commonly used to describe creative and ironic brand imitation in the People's Republic of China today. Until the 1950s, the inhabitants of the Wa hills did indeed live in mountain fortresses—both a pragmatic necessity as well as a miniature repetition of Chinese imperial rule. The pragmatic limitations and creative potential of imitating China are shown for the cases of Maoism, authoritarian capitalism, and contemporary nationhood. Rather than an essentialized feature of Chinese cultural practice, the practices of shanzhai reveal that material and symbolic recombination are essential to creative imitation.
Enhancement of the activity of the antimicrobial peptides HNP1 and LL-37 by bovine pancreatic ribonuclease A
Authors: Ericksen Bryan 
Published: November 2022

Background: HNP1, LL-37, and HBD1 are antimicrobial against Escherichia coli ATCC 25922 at the standard inoculum but less active at higher inocula. Methods: The virtual colony count (VCC) microbiological assay was adapted for high inocula and the addition of yeast tRNA and bovine pancreatic ribonuclease A (RNase). 96-well plates were read for 12 hours in a Tecan Infinite M1000 plate reader and photographed under 10x magnification. Results: Adding tRNA 1:1 wt/wt to HNP1 at the standard inoculum almost completely abrogated activity. Adding RNase 1:1 to HNP1 at the standard inoculum of 5x105 CFU/mL did not enhance activity. Increasing the inoculum to 6.25x107 CFU/mL almost abrogated HNP1 activity. However, adding RNase 25:1 to HNP1 enhanced activity at the highest tested concentration of HNP1. Adding both tRNA and RNase resulted in enhanced activity, indicating that the enhancement effect of RNase overwhelms the inhibiting effect of tRNA when both are present. HBD1 activity at the standard inoculum was almost completely abrogated by the addition of tRNA, but LL-37 activity was only slightly inhibited by tRNA. At the high inoculum, LL-37 activity was enhanced by RNase. HBD1 activity was not enhanced by RNase. RNase was not antimicrobial in the absence of antimicrobial peptides. Cell clumps were observed at the high inoculum in the presence of all three antimicrobial peptides and at the standard inoculum in the presence of HNP1+tRNA and HBD1+tRNA. Conclusions: Antimicrobial peptide-ribonuclease combinations have the potential to be active against high cell concentrations and biofilms, conditions where the antimicrobial agent alone is relatively ineffective.
Sexual and reproductive health and rights knowledge, perceptions, and experiences of adolescent learners from three South African townships: qualitative findings from the Girls Achieve Power (GAP Year) Trial
Authors: Pleaner Melanie , Milford Cecilia , Kutywayo Alison , Naidoo Nicolette , Mullick Saiqa 
Published: November 2022

Background: Adolescence is a time of psycho-social and physiological changes, with increased associated health risks including vulnerability to pregnancy, HIV, sexually transmitted infections, and gender-based violence. Adolescent learners, from three townships in South Africa, participated in a 44 session, after-school asset-building intervention (GAP Year), over 2 years providing sexual and reproductive health (SRH) education. This paper explores adolescent learners’ SRH, sexual risk and rights knowledge; perceptions about transactional sex; and contraceptive method preferences and decision-making practices. Methods: The intervention was conducted in 13 secondary schools across Khayelitsha, Thembisa, and Soweto, South Africa. A baseline survey collected socio-demographic data prior to the intervention. Overall, 26 focus group discussions (FGDs): 13 male and 13 female learner groups, purposively selected from schools, after completing the intervention (2 years after baseline data collection). Descriptive analyses were conducted on baseline data. Qualitative data were thematically coded, and NVivo was used for data analysis. Results: In total, 194 learners participated in the FGDs. Mean age at baseline was 13.7 years (standard deviation 0.91). Participants acquired SRH and rights knowledge during the GAP Year intervention. Although transactional sex was viewed as risky, some relationships were deemed beneficial and necessary for material gain. Negative healthcare provider attitudes were the main barrier to healthcare service utilisation. There was awareness about the benefits of contraceptives, but some myths about method use. The injectable was the preferred contraceptive method, followed by the implant, with equal preference for condoms and oral pill. Conclusions: An afterschool intervention at school is a viable model for the provision of SRH and rights education to learners. Recommendations include the need for risk reduction strategies in the curriculum, dealing with misconceptions, and the promotion of informed decision making. Endeavours to ensure health services are youth friendly is a priority to limit barriers to accessing these services.
Protocol for the Addressing the Social Determinants and Consequences of Tuberculosis in Nepal (ASCOT) pilot trial
Authors: Rai Bhola , Dixit Kritika , Dhital Raghu , Rishal Poonam , Gurung Suman Chandra , Paudel Puskar Raj , Mishra Gokul , Bonnett Laura , Siqueira-Filha Noemia , Khanal Mukti Nath , Lonnroth Knut , Squire S Bertel , Caws Maxine , Wingfield Tom 
Published: November 2022

BACKGROUND: The World Health Organization’s End TB (tuberculosis) Strategy advocates social and economic support for TB-affected households but evidence from low-income settings is scarce. We will evaluate the feasibility and acceptability of a locally-appropriate socioeconomic support intervention for TB-affected households in Nepal. METHODS: We will conduct a pilot randomised-controlled trial with mixed-methods process evaluation in four TB-endemic, impoverished districts of Nepal: Pyuthan, Chitwan, Mahottari, and Morang. We will recruit 128 people with TB notified to the Nepal National TB Program (NTP) and 40 multisectoral stakeholders including NTP staff, civil-society members, policy-makers, and ASCOT (Addressing the Social Determinants and Consequences of Tuberculosis) team members. People with TB will be randomised 1:1:1:1 to four study arms (n=32 each): control; social support; economic support; and combined social and economic (socioeconomic) support. Social support will be TB education and peer-led mutual-support TB Clubs providing TB education and stigma-reduction counselling. Economic support will be monthly unconditional cash transfers during TB treatment with expectations (not conditions) of meeting NTP goals. At 0, 2, and 6 months following TB treatment initiation, participants will be asked to complete a survey detailing the social determinants and consequences of TB and their feedback on ASCOT. Complementary process evaluation will use focus group discussions (FGD), key informant interviews (KII), and a workshop with multi-sectoral stakeholders to consider the challenges to ASCOT’s implementation and scale-up. A sample of ~100 people with TB is recommended to estimate TB-related costs. Information power is estimated to be reached with approximately 25 FGD and 15 KII participants. CONCLUSIONS: The ASCOT pilot trial will both generate robust evidence on a locally-appropriate, socioeconomic support intervention for TB-affected households in Nepal and inform a large-scale future ASCOT trial, which will evaluate the intervention’s impact on catastrophic costs mitigation and TB outcomes. The trial is registered with the ISRCTN (ISRCTN17025974).
Analysis of upper and lower limb movement in infants in response to optic flow - preliminary research
Authors: Pawlak-Andryszczyk Żaneta , Andryszczyk Marek , Topoliński Tomasz , Sobieska Magdalena 
Published: November 2022

Introduction: optic flow is studied in many scientific areas such as automation, robotics, biomechanics and neuropsychology. People who are not visually impaired use this mechanism to move around, usually without realising its complexity. It consists of information provided by the sense of sight and analysed in the central nervous system about the speed and direction of a moving object and the direction and amplitude of the angular and linear components of one's body. However, little is known about how this mechanism develops in the young child.
Objective: Observation of upper and lower limb movement in infants between 4 and 12 weeks. of age under the influence of optic flow stimulation as a stimulus. Development of an optimal test protocol and adaptation of the author's research station.
Material and method: 16 infants aged from 4 to 12 weeks were initially invited to the study, of which 14 infants were finally included in the study group. The motor response test consisted of two stages. Stage I (static trial): the stimulus was a stationary black and white chessboard pattern; stage II (dynamic trial): the chessboard pattern moved toward the child at a speed of 0.17m/s. Cameras recorded the test in both stages.
Results: the children showed increased limb movement under the influence of optical flow (test stage II: dynamic test) compared to stimulation with a fixed pattern (test stage I: static test).
Conclusions: a response to dynamic versus static stimuli was observed in 11 of 14 children, but testing in one-month-olds is unreliable due to poor head control.
Stochastic Zeroth-Order Functional Constrained Optimization: Oracle Complexity and Applications
Authors: Nguyen Anthony , Balasubramanian Krishnakumar 
Published: November 2022

Functionally constrained stochastic optimization problems, where neither the objective function nor the constraint functions are analytically available, arise frequently in machine learning applications. In this work, assuming we only have access to the noisy evaluations of the objective and constraint functions, we propose and analyze stochastic zeroth-order algorithms for solving this class of stochastic optimization problem. When the domain of the functions is [Formula: see text], assuming there are m constraint functions, we establish oracle complexities of order [Formula: see text] and [Formula: see text] in the convex and nonconvex settings, respectively, where ϵ represents the accuracy of the solutions required in appropriately defined metrics. The established oracle complexities are, to our knowledge, the first such results in the literature for functionally constrained stochastic zeroth-order optimization problems. We demonstrate the applicability of our algorithms by illustrating their superior performance on the problem of hyperparameter tuning for sampling algorithms and neural network training.Funding: K. Balasubramanian was partially supported by a seed grant from the Center for Data Science and Artificial Intelligence Research, University of California–Davis, and the National Science Foundation [Grant DMS-2053918].
Station-Based or Free-Floating? An Integrated Carsharing System with Dual Service Types
Authors: Ke Hua , Mo Yutong 
Published: November 2022

A specific service type is applied by most one-way carsharing operators, either station-based or free-floating, which depends on whether users are required to pick up and return vehicles in fixed parking lots. However, both of them have inherent limitations. The station-based carsharing system encounters the weakness of low parking-space utilization, whereas the free-floating system needs to face high parking and relocation costs. To overcome the limitations of single-type carsharing systems, this paper proposes an integrated system to apply the two types in different parts of the service area. A mixed-integer linear-programming model is established to maximize the operator profit, considering both strategic decisions of service type and operational decisions of relocation and trip selection. Despite the fact that the model can be solved by the CPLEX solver, it is limited by excessive memory usage and too long solving time in large-scale cases. To enhance the solving feasibility of the proposed model, a heuristic algorithm is proposed to effectively iterate feasible strategic options and solve the operational subproblem. The numerical results of the case study show that the proposed algorithm can achieve comparable objectives with the CPLEX solver in a much shorter computational time. Through system comparison, the integrated system achieves a larger profit and higher demand-fulfillment rate, compared with the single station-based or free-floating system. History: This paper has been accepted for the Service Science Special Issue on Innovation in Transportation-Enabled Urban Services.
ARAMBURU, C. (Universidad de Salamanca): UGO BETTI, ‘CORRUZIONE AL PALAZZO DI GIUSTIZIA’. EL DRAMA, SU CONTEXTO Y SU TRADUCCIÓN
Authors: Aramburu Sánchez Celia 
Published: November 2022

Corruzione al palazzo di giustizia es un drama muy polémico puesto que cuestiona la honestidad y la eficiencia de la justicia, uno de los pilares del estado moderno. Esta obra se estrenó en Roma en 1949. Por entonces, Italia atravesaba un momento culminante en su transformación como estado dentro del conjunto de Europa. La traducción española es de 1952, y se produjo durante la sexta legislatura del régimen de Franco, cuando aún estaba vigente la censura. En ese contexto resulta bastante extraño que un hombre de teatro como José Luis Alonso se atreviera a traducir y publicar un drama de Ugo Betti, que, leído entre líneas, podía suscitar suspicacias entre los censores.