bluuebunny/crossref_metadata_2025_split huggingface dataset:
The blood pressure variability in patients with cryptogenic stroke
Authors: Alaarag Ahmed , Abdelkhalek Hazem , Amin Osama 
Published: September 2022

Abstract
Background
Increased nighttime BP variability (BPV) was associated with stroke. Left atrial (LA) enlargement is the default clinical hallmark of structural remodeling that often occurs in response to LA pressure and volume overload. Blood pressure has proven to be an essential determinant of LA enlargement. We aimed to evaluate the influence of BPV as a risk factor for cryptogenic stroke and highlight the importance of including the (APBM) in the workup for those patients and test the relation between BPV and LA remodeling in these patients, which could be used as a clue to add APM monitoring to their workup. Also, LA remodeling may be a substrate for occult atrial fibrillation (AF). We included Group I (108 consecutive patients with cryptogenic ischemic stroke) and Group II (100 consecutive adult participants without a history of stroke or any structural heart disease). We measured the maximal LA volume index (Max LAVI) and minimal LA volume index (Min LAVI). We calculated the left atrial ejection fraction (LAEF). All the participants were subjected to ABPM.

Results
In our prospective, cross-sectional cohort study, the patients in Group I had statistically significantly higher Min LAVI and Max LAVI and Less LA EF than Group II, with a P value of (0.001, 0.001, and 0.008), respectively. The Group I patients had higher BPV as measured by SD parameters than patients in Group II, with a P value of 0.001 for all SD parameters. The BPV parameters, as measured by SD parameters, were positively related to the LA remodeling parameters in both groups. After adjusting all variables, we found that age, night systolic SD, and night diastolic SD parameters were independent predictors of LA remodeling.

Conclusions
The patients with cryptogenic stroke had higher short-term BPV, Min LAVI, and Max LAVI but lower LA EF. Careful monitoring of BPV may be of value for both primary and secondary preventions of ischemic stroke.
The impact of polymorphism in PNPLA3 and TM6SF2 genes on the susceptibility and survival of hepatitis C-related hepatocellular carcinoma
Authors: Youssef Samar Samir , Abbas Eman Abd El Razek , Elfiky Asmaa M. , Seif Sameh , Nabeel Mohamed Mahmoud , Shousha Hend Ibrahim , Abdelaziz Ashraf Omar 
Published: September 2022

Abstract
Background
Genetic variants of Patatin-like phospholipase domain-containing protein 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2) genes have been reported with the development of hepatocellular carcinoma (HCC). This study aims to explore the role of The PNPLA3 rs738409 and TM6SF2 rs58542926 single-nucleotide polymorphisms (SNPs) on the incidence and survival of HCV-induced HCC in Egyptians.

Methods and results
This case-control study included (120) HCC and (144) hepatitis C virus (HCV) patients. Baseline clinical, laboratory, tumor characteristics data, HCC recurrence, and overall survival were collected. PNPLA3 rs738409 and TM6SF2 rs58542926 polymorphism were detected by TaqMan allelic discrimination assay. We found that HCC patients were significantly older with male predominance. A significant difference between the TT genotypes of TM6SF2 frequency was observed in HCC compared with HCV patients. Moreover, the T allele of TM6SF2 distributions revealed a significant contribution to the different stages of HCC (p=0.03). Both PNPLA3 rs738409 and TM6SF2 rs58542926 variants showed a significant relation with treatment response according to the modified RECIST criteria. Age and diabetes mellitus were the independent factors associated with the development of HCC by multivariate regression analysis.

Conclusions
TM6SF2 rs58542926 polymorphism, not PNPLA3 rs738409, could be implicated in the development of HCV-induced HCC and its progression.
A system dynamics model of the impact of COVID-19 pandemic and foreign direct investment in the global supply chain
Authors: Hajian Heidary Mojtaba 
Published: September 2022

AbstractCOVID-19 pandemic is a great challenge that the world has been faced in recent decades. The pandemic has affected the global trade and has caused a dramatic fall in Foreign Direct Investments (FDI). The impact on FDI is concentrated in the countries that are severely hit by the pandemic, although negative impact of disruptions is observed in other countries. In this paper, a system dynamics model is developed to simulate the impact of the pandemic on the FDI. Results showed that the level of force majeure condition and also the level of flexibility are two important factors that impact on the FDI and other important variables of the supply chain. In the case of lower severity of pandemic and higher flexibility, FDI is higher than the case that these parameters are in their worst condition.
Assessment of quality of life by functional independence score in hemophilic patients: a single-center experience
Authors: Ibrahiem Osama Ahmed , Thabet Ahmad F. , Tony Shymaa S. , Kerollos Kerollos Motwade N. , Moeen Sawsan M. 
Published: September 2022

Abstract
Background
Hemophilia is an inherited condition that is caused by the deficiency of clotting factors in the blood. The most common presentations of hemophilia are hemarthrosis and muscle hemorrhage. The severity of the bleeding episodes can vary from mild to severe resulting in pain and swelling of the joints and the muscles. Repeated musculoskeletal bleeding can result in hemophilic arthropathies with subsequent joint degeneration and deformity. Our study aims to clinically assess the quality of life in hemophilic patients in terms of disease severity and morbidity in our community using the Functional Independence Score for Hemophilia (FISH).

Results
Our cross-sectional study which involved 64 hemophilia patients revealed that the most affected joints were the weight-bearing large joints (knees, elbows, ankles) and this was associated with a lower FISH score. While the total FISH score showed a significant positive correlation with the factor activity level, the average FISH score was 21.11 ± 4.5, and the score was slightly lower in severe hemophilia compared to mild-moderate disease.

Conclusion
We concluded that there is a significant decline in the functional ability of hemophilia patients having disease affecting the knee and elbow joints. Moreover, squatting was significantly reduced in patients with severe hemophilia. The quality of patients’ life can be improved by early and regular physiotherapy and regular administration of the prophylactic factor.
Understanding of the settlements with coexisting water and earth under the background of climate change—the case of Liang Village in Pingyao County, China
Authors: Shao Yong , Chen Yue , Su Jianming 
Published: September 2022

AbstractGlobal climate change has caused general and serious damage to cultural heritage sites, and earthen settlements and buildings are particularly vulnerable to water-affected disasters. Thus, this paper uses Liang Village in Pingyao County, China, as a case study, linking the human–land study in the Liang Village Sino-French workshop of 2009/2010 to a disaster assessment completed after the devastating rainstorm in October 2021. We found that the village’s rain disaster resulted from the vulnerability of earthen material to rainstorms and from the earthen settlement’s evolution from a culture emphasising the coexistence of ‘water and earth’ to a technic fostering the disintegration of ‘water and earth’. The latter is the main cause of the village’s decrease in its capacity for disaster prevention and damage reduction. Therefore, in the context of global climate change, we find that the reestablishment of the harmonious relationship of water and earth is critical to both rural heritage conservation and village sustainable development. In addition to repairing their relation from the technical perspective of ‘planning and design’ by planners and architects, it is more crucial for local people to understand and enhance their contemporary appreciation for the traditional ‘coexistence of water and earth’ concept.
Loss of Anti-Müllerian Hormone Signaling in Mice Affects Trabecular Bone Mass in a Sex- and Age-Dependent Manner
Authors: van As Christiane , Koedam Marijke , McLuskey Anke , Kramer Piet , Lahlou Najiba , van der Eerden Bram C J , Visser Jenny A 
Published: September 2022

Abstract
Ovariectomy-induced osteoporosis in mice results from an abrupt loss of ovarian sex steroids. Anti-Müllerian hormone knockout (AMHKO) mice show a gradual but accelerated ovarian aging, and therefore may better resemble osteoporosis following natural menopause. To study the impact of AMH signaling deficiency on bone, we compared trabecular and cortical bone parameters in 2-, 4-, 10-, and 16-month-old male and female wild-type (WT), AMHKO, and AMH type II receptor knockout (MRKI) mice using micro computed tomography (microCT). Goldner's staining was performed to confirm the observed bone phenotype. Both male and female AMHKO and MRKI mice showed age-dependent loss of trabecular bone (P &lt; 0.001). However, reproductive-aged female AMHKO and MRKI mice had higher BV/TV compared with WT (P &lt; 0.001), coinciding with increased growing follicle numbers (P &lt; 0.05) and increased estrus inhibin B levels (AMHKO: P &lt; 0.001; MRKI: P &lt; 0.05) but normal inhibin A, estrogen, and progesterone levels. In aged female AMHKO and MRKI mice BV/TV did not differ from WT mice due to greater trabecular bone loss between 10 and 16 months compared with WT mice. At these ages, AMHKO and MRKI mice had reduced growing follicle numbers (P &lt; 0.05) and reduced inhibin B levels (P &lt; 0.001). At age 10 months, female MRKI mice had increased cortical bone parameters compared with WT mice (P &lt; 0.01). Bone parameters of male AMHKO and MRKI mice did not differ from male WT mice. In conclusion, AMH signaling deficiency results in a sex- and age-dependent effect on predominantly trabecular bone. Our results further suggest that reproductive hormones beyond estrogen may contribute to bone homeostasis.
Foxe1Deletion in the Adult Mouse Is Associated With Increased Thyroidal Mast Cells and Hypothyroidism
Authors: Lim Grace , Widiapradja Alexander , Levick Scott P , McKelvey Kelly J , Liao Xiao-Hui , Refetoff Samuel , Bullock Martyn , Clifton-Bligh Roderick J 
Published: September 2022

AbstractContextFoxe1 is a key thyroid developmental transcription factor. Germline deletion results in athyreosis and congenital hypothyroidism. Some data suggest an ongoing role for maintaining thyroid differentiation.ObjectiveWe created a mouse model to directly examine the role of Foxe1 in the adult thyroid.MethodsA model of tamoxifen-inducible Cre-mediated ubiquitous deletion of Foxe1 was generated in mice of C57BL/6J background (Foxe1flox/flox/Cre-TAM). Tamoxifen or vehicle was administered to Foxe1flox/flox/Cre mice aged 6-8 weeks. Blood was collected at 4, 12, and 20 weeks, and tissues after 12 or 20 weeks for molecular and histological analyses. Plasma total thyroxine (T4), triiodothyronine, and thyrotropin (TSH) were measured. Transcriptomics was performed using microarray or RNA-seq and validated by reverse transcription quantitative polymerase chain reaction.ResultsFoxe1 was decreased by approximately 80% in Foxe1flox/flox/Cre-TAM mice and confirmed by immunohistochemistry. Foxe1 deletion was associated with abnormal follicular architecture and smaller follicle size at 12 and 20 weeks. Plasma TSH was elevated in Foxe1flox/flox/Cre-TAM mice as early as 4 weeks and T4 was lower in pooled samples from 12 and 20 weeks. Foxe1 deletion was also associated with an increase in thyroidal mast cells. Transcriptomic analyses found decreased Tpo and Tg and upregulated mast cell markers Mcpt4 and Ctsg in Foxe1flox/flox/Cre-TAM mice.ConclusionFoxe1 deletion in adult mice was associated with disruption in thyroid follicular architecture accompanied by biochemical hypothyroidism, confirming its role in maintenance of thyroid differentiation. An unanticipated finding was an increase in thyroidal mast cells. These data suggest a possible explanation for previous human genetic studies associating alleles in/near FOXE1 with hypothyroidism and/or autoimmune thyroiditis.
PUBLICAÇÕES TÉCNICAS PARA A ÁREA DO DIREITO
Authors: Silva Altiéres De Oliveira , Rodrigues Leonel Cezar , Martins Cibele Barsalini , Sellos-Knoerr Viviane Coelho de 
Published: September 2022

Objetivo do estudo: O objetivo do estudo é apresentar diretrizes que permitam tanto a elaboração quanto a avaliação de artigos de caráter técnico ou tecnológico para a área do Direito.Abordagem Metodológica: O presente estudo, de natureza qualitativa e prescritiva, é baseado em dados e informações secundárias e documentais.Relevância: Apesar do caráter aplicado das teorias na ciência jurídica, doutrinas em Direito com acentuado cunho hermenêutico subjetivo, possuem tradicionalmente grande implicações sobre a prática jurídica no cotidiano. A prática, assim, tende a seguir ramos doutrinários com maior aceitação. Novas abordagens, contudo, têm sido restringidas por causa da baixa familiaridade dos operadores com estruturas de solução mais adequadas à área jurídica. Apenas muito recentemente, com o advento da Pós-Graduação profissionalizante, as publicações de natureza técnica, que refletem métodos e técnicas mais alinhados com a natureza das intervenções em Direito assumem maior espaço na literatura e precisam de diretrizes que possam ajudar em sua aceitação pela academia e pelos praticantes da área jurídica. Principais resultados: Indicam o aumento de publicações desse gênero textual para os pesquisadores e operadores do Direito. Constata-se, em adição, a crescente importância deste tipo de produção intelectual, no sistema de avaliação da PGSS da CAPES. Assim, a análise contextual da produção técnica indica também sua utilidade para os operadores do Direito. Dessa forma, considerando a confusão conceitual ainda reinante entre artigos científicos e artigos técnicos, sugere-se diretrizes que possam nortear a elaboração da crescente produção técnica na área de Direito. Contribuições teóricas/metodológicas: A proposta de um design estrutural para a elaboração de artigos técnicos ou tecnológicos.Conclusão: Embora a área do Direito utilize esse tipo de publicação, não há diretrizes, oriundas da área técnica do Direito, para a produção de artigos técnicos ou tecnológicos. Assim, considera-se imperioso a organização de diretrizes que possam apoiar os pesquisadores e profissionais do Direito na elaboração de publicações direcionadas para intervenções em atividades jurídicas, com maior segurança. Dessa forma, julga-se estar contribuindo para a consolidação dos padrões básicos da literatura de caráter técnico em apoio ao exercício profissional mais eficiente dos operadores de Direito.
The effectiveness of a pain management programme on pain control and quality of life in patients with metastatic cancer
Authors: Prisutkul Apinya , Dechaphunkul Arunee , Arundorn Tippawan , Songserm Maliwan , Ruangdam Anongnart , Sathitruangsak Chirawadee 
Published: September 2022

Background: Pain is one of the most frequent symptoms in cancer patients and has a negative impact on their physical, emotional and functional status, as well as their quality of life (QOL). This study evaluated the effectiveness of a pain management programme on pain control and QOL among patients with metastatic cancer receiving systemic chemotherapy. The authors investigated whether a pain management programme contributes to a better pain control and improvement in QOL in the outpatient setting. Methods: The authors conducted a randomised, single-blinded, controlled, single-centre study of metastatic cancer patients experiencing cancer pain and requiring opioid therapy. Patients were enrolled from the Medical Oncology Outpatient Clinic, Songklanagarind Hospital, Prince of Songkla University, Thailand. Participants were randomly assigned to two strategies: pain assessment and management based on the programme developed by the researchers (‘pain management programme’ arm), and pain management by individual medical oncologists per the routine procedure (‘standard of care’ arm). Demographics questionnaires, a pain intensity assessment using the Numeric Rating Scale (NRS) and the Functional Assessment of Cancer Therapy—General (FACT-G, version 4) were used to assess the QOL and cancer pain severity at baseline and at two follow-up visits. Results: Between November 2016 and July 2017, 64 consecutive patients were randomly assigned to the two treatment groups. Most were male (79.7%), with a mean age of 55.1 (±13.8) years. The majority of patients (23; 35.9%) had squamous cell carcinoma of the head and neck, with other prevalent types being lung cancer (9.4%), esophageal cancer (9.4%) and colorectal cancer (9.4%). The most frequent metastatic sites were the lungs (28.1%), liver (26.6%), and bone (20.3%). Findings: Compared with standard care, pain intensity was significantly lower among the patients receiving the pain management programme: 4.0 ±2.2 versus 5.1 ±1.8 (P = 0.033) and 3.3 ±1.7 versus 4.7 ±2.1 (P = 0.025) at visit 1 and 2, respectively. Likewise, QOL measures scored higher in the pain management programme group: 71.2 ±15.4 versus 58.6 ±14.5 (P = 0.002) and 71.8 ±15.5 versus 55.4 ±16.3 (P = 0.002) at visit 1 and 2, respectively. Furthermore, there was a statistically significant positive correlation between pain control and QOL improvement (P = 0.011). Conclusion: The investigated pain management programme significantly improved both pain control and QOL in metastatic cancer patients receiving systemic chemotherapy in the outpatient setting.
Exploring the role of the UK renal social worker: The nexus between health and social care for renal patients
Authors: Seekles Maaike L. , Ormandy Paula 
Published: September 2022

Introduction
Patients living with progressive chronic kidney disease may face a variety of ongoing physical, emotional, financial and/or social challenges along the disease pathway. In most UK renal units, psychosocial support has traditionally been provided by a renal social worker. However, in recent years, the numbers of renal social workers have been declining. The specialised role is poorly understood and there is no UK research about the profession. To inform future research and guide workforce planning, this study presents the first-ever exploration of the UK renal social worker role. It aimed to map the profession’s activities and reasons for involvement in patient care, as well as providing an initial evaluation of that involvement on patient wellbeing.

Methods and analysis
This mixed-method study recruited adult renal social workers (n = 14), who completed diaries over a 4-month period, participated in a focus group, and provided secondary data (caseload data and audit files where available) to give insight into their role. The evaluation of social work involvement on patient wellbeing used a pre-post intervention design. It measured distress, anxiety and depression levels as captured by the Distress Thermometer and Emotional Thermometers. A total of 161 patients completed the pre-involvement questionnaire, and 87 (55%) returned the post-involvement questionnaire.

Results and conclusion
The renal social worker role is creative, broad and fluid, with variations in roles linked to differences in employment and funding arrangements, configurations of the wider multidisciplinary renal team, level of standardisation of psychosocial care, availability of community services, and staff-to-patient ratios. Renal social work is different from statutory social work, and renal social workers are generally able to offer continuous rather than episodic care and support patients that would not meet strict local authority eligibility criteria. The findings showed that this support leads to significantly reduced distress and anxiety.
Fred Rogers’s Ecological Imagination
Authors: Lindey Sara , King Jason 
Published: September 2022

Fred Rogers was an international celebrity. He was a pioneer in children’s television, an advocate for families, a multimedia artist and performer, and a spiritual leader and pastor. He wrote, produced, and starred in his children’s television show, Mister Rogers Neighborhood, from 1968 to 2001, in almost 900 episodes tackling topics important to children and families. This Introduction explores Rogers’ spiritual depths, looking to his sermons and lectures that ground and propel his ecological imagination and practical environmentalism.
Coaxial resonant cavity for measuring complex permittivity of liquids
Authors: Wang Yi , Xu Zhixia , Feng Yulin , Fang Shaojun 
Published: September 2022

Abstract
In this letter, a new microwave sensor of the coaxial resonant cavity with a single-open-ended circuit loaded capacitor is proposed and used to detect the liquids’ complex permittivity. The improved cavity has a higher internal electric field and smaller size when compared with the cylindrical cavity, which gives the sensor a high sensitivity in measuring liquids’ complex permittivity. A coaxial resonant cavity operating in 1.9 GHz was designed in this work. The silicone hose used for the test is inserted vertically from the center of the cavity, and the liquids under test (LUTs) are guaranteed to be 2 ml each time. The dielectric properties of LUTs will cause perturbation to the internal electric field of the cavity. By analyzing the measured data, the sensitivity of the cavity is 0.12%, and the relative errors of the real part of the measured value and the reference value are 3.67%. which shows the measured value has a good agreement with the reference value.
Organizational humor as making our work more meaningful: mediation by crafting job resources
Authors: Turnalar-Çetinkaya Neslihan , Keskin İrem N. , Bora Gamze , İkan Reyhan , Gümrükçü Şeyma 
Published: September 2022

AbstractIn the present study, we examined the impact of humor’s positive functions on the perception of a job’s meaningfulness. We argued that liberating and stress-relieving humor act as job resources enhancing job crafting to increase social and structural resources to experience meaningfulness. We hypothesized that crafting the job to increase structural and social resources would mediate the link between organizational humor functions (i.e., liberating and stress-relieving) and meaningfulness. We conducted a cross-sectional study among 200 Turkish employees from different occupations. Our results revealed that increasing structural resources mediated the relationship between liberating humor and meaningfulness, while this mediation was partially for stress-relieving humor. The mediating role of increasing social resources was partial and conditional for both types of organizational humor functions. The practical and theoretical implications have been discussed from a positive organizational scholarship perspective.