bluuebunny/crossref_metadata_2025_split huggingface dataset:
PELATIHAN DALAM PENGGUNAAN INFORMED CONSENT PADA FASILITAS PELAYANAN KESEHATAN
Authors: Setiyoargo Arief , Marbun Romaden , Maxelly Richard One 
Published: October 2022

This Community Service activity aims to improve the quality of health services through understanding the use of informed consent. This activity begins with an initial assessment of the current state of the field in health care facilities through health workers/health cadres and residents. The initial assessment found that there was still a lack of public knowledge about medical treatment for patients and knowledge related to the use of informed consent in health facilities, especially during the current Covid-19 pandemic, the focus of health services is still centered on health protocols or physical distancing. The activity begins with preparing a plan and schedule of activities as well as the necessary equipment. The form of activities is packaged in the form of materials and videos that are shared via Google Drive online via WhatsApp groups. The activity ended with an evaluation using a google form. The results of community service activities there are as many as 57,69% of citizens' understanding in the good category, 26,92% sufficient and 15,38% less. Activities are going well and need further monitoring.

Kegiatan Pengabdian kepada Masyarakat ini bertujuan untuk meningkatkan kualitas pelayanan kesehatan melalui pemahaman penggunaan informed consent. Kegiatan ini diawali dengan penilaian awal kondisi terkini di lapangan di fasilitas pelayanan kesehatan melalui petugas kesehatan/kader kesehatan dan warga. Asesmen awal menemukan masih kurangnya pengetahuan masyarakat tentang penanganan medis bagi pasien dan pengetahuan terkait penggunaan informed consent di fasilitas kesehatan terutama pada masa pandemi Covid-19 saat ini, fokus pelayanan kesehatan masih berpusat pada kesehatan. protokol atau jarak fisik. Kegiatan diawali dengan penyusunan rencana dan jadwal kegiatan serta perlengkapan yang diperlukan. Bentuk kegiatan dikemas dalam bentuk materi dan video yang dibagikan melalui google drive secara online melalui grup WhatsApp. Kegiatan diakhiri dengan evaluasi menggunakan google form. Hasil kegiatan pengabdian masyarakat terdapat sebanyak 57,69% pemahaman warga dalam kategori baik, 26,92% cukup dan 15,38% kurang. Kegiatan berjalan dengan baik dan perlu pemantauan lebih lanjut.
PEMANFAATAN BUKU ILUSTRASI BERBASIS KEARIFAN LOKAL SEBAGAI MEDIA LITERASI DI TAMAN BACA KESIMAN
Authors: Suciartini Ni Nyoman Ayu , Kurniarini Ni Nyoman Yunika , Dewi Ni Luh PT. Putriyani , Brahman I Made Adi 
Published: October 2022

This community service includes the use of illustration books based on local wisdom as a literacy medium at the Taman Baca Kesiman with the breath of literacy as a benchmark. Religious literacy is a priority program at the Directorate General of Hindu Guidance, to welcome the year of tolerance 2022. Given this, efforts are needed to strengthen literacy and insight into religion. Literacy is not enough to be interpreted as merely reading and writing activities, but requires critical thinking skills in assessing scientific sources in print, visual, digital, and auditory forms which are expected to be able to develop a literate and moderate attitude. The purpose of this service activity is to provide media for Hindu religious literacy based on local wisdom to visitors and staff in the Taman Baca Kesiman environment, explore local wisdom based on Hinduism which will be illustrated both digitally and in print, and visitors and management staff at Taman Baca Kesiman have media Hindu religious literacy based on local wisdom. The method of implementing the activity is the presentation method, namely the presentation of material from resource persons with deepening of material related to basic knowledge of literacy, religious literacy, understanding the local wisdom of Tri Hita Karana, as well as training by using illustration books based on Balinese local wisdom as literacy media.

Pengabdian masyarakat ini memuat pemanfaatan buku ilustrasi berbasis kearifan lokal sebagai media literasi di Taman Baca Kesiman dengan napas literasi sebagai tolok ukurnya. Literasi agama adalah program prioritas di Ditjen Bimas Hindu, untuk menyambut tahun toleransi 2022. Mengingat hal tersebut, diperlukan upaya-upaya untuk memperkuat literasi dan wawasan dalam beragama. Literasi tidak cukup hanya dimaknai dengan hanya sekadar kegiatan membaca dan menulis, namun menuntut adanya keterampilan berpikir kritis dalam menilai sumber-sumber ilmu baik dalam bentuk cetak, visual, digital, dan auditori yang diharapkan mampu mengembangkan sikap literat dan moderat. Tujuan kegiatan pengabdian ini untuk memberikan media literasi agama Hindu berbasis kearifan lokal kepada pengunjung dan staf di lingkungan Taman Baca Kesiman, menggali kearifan lokal berbasis agama Hindu yang akan dibuatkan ilustrasi baik secara digital maupun cetak, dan pengunjung dan staf pengelola di Taman Baca Kesiman memiliki media literasi agama Hindu berbasis kearifan lokal. Adapun metode pelaksanaan kegiatan yaitu dengan metode presentasi yaitu pemaparan materi dari narasumber dengan pendalaman materi terkait pengetahuan dasar literasi, literasi agama, pemahaman kearifan lokal Tri Hita Karana, serta pelatihan dengan memanfaatkan buku ilustrasi berbasis kearifan lokal Bali sebagai media literasi.
Teacher Educators and Trainee Teachers' Attitude toward Online Teacher Education Courses
Authors: Ahmed Md. Meraz , Md. Rokonuzzaman  , Hossain Md. Kamal 
Published: October 2022

The purpose of the study was to explore the attitude toward Online Teacher Education Courses (OTECs). To that end, this study was carried out over the teacher educators and trainee teachers of Bangladesh Open University. Here, teacher educators represent the faculty members of the School of Education (SoE) of Bangladesh Open University (BOU), and trainee teachers represent the Master of Education (M.Ed.) and Bachelor of Education (B.Ed.) students of BOU. A mixed research approach with triangulation was used to conduct the study with a descriptive survey, two Focus Group Discussions (FGDs), and one key personnel interview. Data were collected from a total of 602 teacher trainees (182 were M.Ed. students and 420 were B.Ed. students) and 12 teacher educators, selected through multiple sampling techniques. The data revealed that the teacher educators and trainee teachers had a positive attitude towards online courses since the mean score of faculty members, M.Ed., and B.Ed. students of BOU were 3.60, 381, and 3.81, respectively. Considering all these aspects, this study suggested that SoE/BOU needs to decide rationally to shape its future Online Teacher Education Courses (OTECs). This research contributes to the basement of new knowledge through an explorative study with all the possible stakeholders covering the whole country of interest.
Recovery of carbon and cryolite from spent carbon anode slag of electrolytic aluminum by flotation based on the evaluation of selectivity index
Authors: Wang Yemin , Wang Xuexia , Bilal Muhammad 
Published: October 2022

One of the main electrolytic aluminum production costs is the consumption of carbon anodes, and carbon anode slag is a common hazardous waste in the aluminum industry. In this work, electrolytic aluminum carbon anode slag was separated by flotation. Using the selectivity index (SI) as an indicator, the influencing factors of the carbon slag flotation process were optimized, and the separation performance of carbon and cryolite in the carbon anode slag was investigated. The raw carbon anode slag was ground for 40 min to achieve dissociation of the cryolite from the carbon, the optimized SI value was then used to determine the optimal flotation test conditions. The test results showed that the SI value under the optimal grinding flotation was approximately four times larger than the value of direct flotation. This indicated that carbon anode slag had a better flotation selectivity under the grinding flotation, which significantly improved the flotation performance.
Electrocardiographic criteria for localization of ventricular premature complexes from the inferior right ventricular outflow tract
Authors: Li Kang , Lv Pinchao , Wang Yuchuan , Fan Fangfang , Ding Yansheng , Li Jianping , Zhou Jing 
Published: October 2022

BackgroundThe ventricular premature complexes (PVCs) originating from the superior right ventricular outflow tract (RVOT) have high success rates by catheter ablation. It may not be the same when the origin is in the inferior RVOT.ObjectiveTo identify electrocardiographic (ECG) characteristics that predict the site for successful ablation of PVCs originating in the inferior RVOT.MethodsOf 309 consecutive patients with symptomatic PVCs despite medical therapy, 124 had PVCs originating from the RVOT, and 107 RVOT cases without structural heart disease and no bundle branch block in sinus rhythm were enrolled in the study. Among them, 74 have a superior RVOT origin, and 33 have an inferior RVOT origin.ResultsThe proportion with multiple morphologies of PVC was significantly higher in the inferior RVOT group than in the superior RVOT group (24.24 vs. 6.76%, P = 0.011). The QRS duration of PVCs with an inferior RVOT origin was more expansive than PVCs with a superior RVOT origin (162.42 ± 19.69 ms vs. 140.90 ± 11.30 ms; P &lt; 0.001). Furthermore, the QRS wave in V1 in patients in the inferior RVOT group was more likely to have a negative delta wave at the onset of the QRS (27.27 vs. 1.39%, P &lt; 0.001). We found that the areas under the receiver-operating characteristic curve (AUCs) for PVC diagnosis with an inferior RVOT origin ranged from 0.812 to 0.841 depending on ECG features, with the highest AUC for the QRS duration of PVCs and the amplitude of R waves in lead II. These ECG indices had good predictability for judging the origin of PVCs in the RVOT; the best threshold for the QRS duration of PVCs was 145 ms, and the best thresholds for the amplitude of R waves in leads II, III, and aVF were 1.35, 1.35, and 1.15 mV, respectively.ConclusionWhen evaluating a patient with PVCs, the source is likely to be the inferior RVOT if the ECG presentation conforms to the morphological characteristics of the RVOT, meanwhile, the QRS wave is relatively broad and polymorphic, and the main waves in limb leads (II, III, and aVF) are upward with low amplitude.
Human embryonic stem cell-derived endothelial cell product injection attenuates cardiac remodeling in myocardial infarction
Authors: Spiroski Ana-Mishel , McCracken Ian R. , Thomson Adrian , Magalhaes-Pinto Marlene , Lalwani Mukesh K. , Newton Kathryn J. , Miller Eileen , Bénézech Cecile , Hadoke Patrick , Brittan Mairi , Mountford Joanne C. , Beqqali Abdelaziz , Gray Gillian A. , Baker Andrew H. 
Published: October 2022

BackgroundMechanisms contributing to tissue remodeling of the infarcted heart following cell-based therapy remain elusive. While cell-based interventions have the potential to influence the cardiac healing process, there is little direct evidence of preservation of functional myocardium.AimThe aim of the study was to investigate tissue remodeling in the infarcted heart following human embryonic stem cell-derived endothelial cell product (hESC-ECP) therapy.Materials and methodsFollowing coronary artery ligation (CAL) to induce cardiac ischemia, we investigated infarct size at 1 day post-injection in media-injected controls (CALM, n = 11), hESC-ECP-injected mice (CALC, n = 10), and dead hESC-ECP-injected mice (CALD, n = 6); echocardiography-based functional outcomes 14 days post-injection in experimental (CALM, n = 13; CALC, n = 17) and SHAM surgical mice (n = 4); and mature infarct size (CALM and CALC, both n = 6). We investigated ligand–receptor interactions (LRIs) in hESC-ECP cell populations, incorporating a publicly available C57BL/6J mouse cardiomyocyte-free scRNAseq dataset with naive, 1 day, and 3 days post-CAL hearts.ResultsHuman embryonic stem cell-derived endothelial cell product injection reduces the infarct area (CALM: 54.5 ± 5.0%, CALC: 21.3 ± 4.9%), and end-diastolic (CALM: 87.8 ± 8.9 uL, CALC: 63.3 ± 2.7 uL) and end-systolic ventricular volume (CALM: 56.4 ± 9.3 uL, CALC: 33.7 ± 2.6 uL). LRI analyses indicate an alternative immunomodulatory effect mediated via viable hESC-ECP-resident signaling.ConclusionDelivery of the live hESC-ECP following CAL modulates the wound healing response during acute pathological remodeling, reducing infarct area, and preserving functional myocardium in this relatively acute model. Potential intrinsic myocardial cellular/hESC-ECP interactions indicate that discreet immunomodulation could provide novel therapeutic avenues to improve cardiac outcomes following myocardial infarction.
Associations between serum 25-hydroxyvitamin D, body mass index and body fat composition among Emirati population: Results from the UAE healthy future study
Authors: AlAnouti Fatme , Ahmad Amar Sabri , Wareth Laila Abdel , Dhaheri Ayesha Al , Oulhaj Abderrahim , Junaibi Abdulla Al , Naeemi Abdullah Al , Hamiz Aisha Al , Hosani Ayesha Al , Zaabi Eiman Al , Mezhal Fatima , Maskari Fatma Al , Alsafar Habiba , Yaaqoub Jamila , Bastaki Marina Al , Houqani Mohammed Al , Oumeziane Naima , Juber Nirmin F. , Sherman Scott , Shah Syed M. , Alsharid Teeb , Zaabi Thekra Al , Loney Tom , Mahmeed Wael Al , Abdulle Abdishakur , Ali Raghib 
Published: October 2022

IntroductionVitamin D deficiency and insufficiency are highly prevalent among several populations across the globe. Numerous studies have shown a significant correlation between body-mass-index (BMI) and Vitamin D status, however, some results differed according to ethnicity. Despite the abundance of sunshine throughout the year, vitamin D deficiency is prominent in the United Arab Emirates (UAE). In this study, we analyzed the UAE Healthy Future Study (UAEHFS) pilot data to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) and % body fat (BF) composition as well as BMI.Material and methodsData from a total of 399 Emirati men and women aged ≥ 18 years were analyzed. Serum 25(OH)D and standard measures of weight and height were included in the analyses. Vitamin D deficiency was defined as serum 25(OH)D concentration&lt;20 ng/ml. Multivariate quantile regression models were performed to explore the relationship between serum 25(OH)D levels and % BF composition and BMI correspondingly.ResultsThere were 281 (70.4%) males and 118 (29.6%) females included in this study. More than half of the study participants had vitamin D insufficiency (52.4%), and nearly a third had vitamin D deficiency (30.3%); while only 17.3% had optimal levels. A statistically significant negative association between serum 25(OH) D levels and % BF composition was observed at intermediate percentiles while a statistically significant negative association between serum 25(OH)D and BMI was only observed at the median (50th percentile).ConclusionThe study findings support the association between low serum 25(OH) D levels (low vitamin D status) and high % BF composition and high BMI among adult Emiratis. Further longitudinal data from the prospective UAEHFS could better elucidate the relationship between serum 25(OH) D levels, % BF composition, and BMI in the context of various health outcomes among this population.
Integration of transcriptome and metabolome analyses reveals key lodging-resistance-related genes and metabolic pathways in maize
Authors: Liu Lei , Liu Songtao , Lu Haibo , Tian Zaimin , Zhao Haichao , Wei Dong , Wang Shuo , Huang Zhihong 
Published: October 2022

Stalk lodging, or breakage of the stalk at or below the ear, is one of the vital factors causing substantial yield losses in maize (Zea mays. L). Lodging affects maize plants’ physiological and molecular processes, eventually impacting plant growth and productivity. Despite this known fact, few researchers have investigated the genetic architecture underlying lodging in maize. Herein, through integrated transcriptome, metabolome, and phenotypic analyses of stalks of three diverse hybrid cultivars (highly resistant JNK738, mildly resistant JNK728, and lowly resistant XY335) at the tasseling (10 days to silking, 10 DTS) stage, we identified key genes and metabolic pathways modulating lodging resistance in maize. Based on the RNA-Seq analysis, a total of 10093 differentially expressed genes (DEGs) were identified from the comparison of the three varieties in pairs. Additionally, key lodging resistance–related metabolic pathways were obtained by KEGG enrichment analysis, and the DEGs were found predominantly enriched in phenylpropanoid and secondary metabolites biosynthesis pathways in the L_vs._H and M_vs._H comparison groups. Moreover, K-means analysis clustered the DEGs into clear and distinct expression profiles for each cultivar, with several functional and regulatory genes involved in the cell wall assembly, lignin biosynthetic process and hormone metabolic process being identified in the special clusters related to lodging resistance. Subsequently, integrating metabolome and transcriptome analyses revealed nine key lignin-associated metabolites that showed different expression trends in the three hybrid cultivars, among which L-phenylalanine and p-coumaric acid were regarded as differentially changed metabolites (DCMs). These two DCMs belonged to phenylalanine metabolism and biosynthesis pathways and were also supported by the RNA-Seq data. Furthermore, plant hormone signal transduction pathway–related genes encoding auxin, abscisic acid, jasmonates, and salicylic acid were differentially expressed in the three comparisons of lodging resistance, indicating these DEGs were valuable potential targets for improving maize lodging resistance. Finally, comparative physiological and qRT-PCR analyses results supported our transcriptome-based findings. Our research not only provides a preliminary theoretical basis and experimental ideas for an in-depth study of the regulatory networks involved in maize lodging resistance regulation but also opens up new avenues for molecular maize stalk lodging resistance breeding.
Cumulative evidence for associations between genetic variants in interleukin 17 family gene and risk of human diseases
Authors: Liu Tianyu , Yang Lei , Lv Xiaolong , Zuo Chunjian , Jia Chenhao , Yang Zelin , Fan Chongqi , Chen Huanwen 
Published: October 2022

BackgroundGenetic association studies have elucidated the link of variants in the interleukin 17 (IL-17) family genes with susceptibility to human diseases, yet have obtained controversial outcomes. Therefore, we sought to update comprehensive synopsis of variants in the IL-17 family genes with susceptibility to human diseases.MethodsOur study screened the Pubmed and Web of Science to enroll eligible articles and performed a meta-analysis, then graded the cumulative evidence of significant association using Venice criteria and false-positive report probability test, and finally assessed the function of variants with strong evidence.ResultsSeven variants in IL-17 family genes had significant relationships with susceptibility to 18 human diseases identified by meta-analyses. Strong evidence was assigned to 4 variants (IL-17A rs2275913, IL-17A rs8193037, IL-17F rs1889570, IL-17F rs763780) with susceptibility to 6 human diseases (lung and cervical cancer, spondyloarthritis, asthma, multiple sclerosis, rheumatoid arthritis), moderate to 2 variants with risk of 5 diseases, weak to 5 variants with risk of 10 diseases. Bioinformatics analysis suggested that the variants with strong evidence might fall in putative functional regions. Additionally, positive relationships for 5 variants with risk of 4 diseases (based on two datasets) and 14 variants with risk of 21 diseases (based on one dataset) were considered noteworthy.ConclusionsThis study offers updated and comprehensive clues that variants in the IL-17 family genes are significantly linked with susceptibility to cervical, lung cancer, asthma, multiple sclerosis, rheumatoid arthritis and spondyloarthritis, and elucidates the crucial role of the IL-17 regions in the genetic predisposition to cancer or noncancerous diseases.
Combining single-cell sequencing data to construct a prognostic signature to predict survival, immune microenvironment, and immunotherapy response in gastric cancer patients
Authors: Hu Bo , Meng Yan , Qu Chao , Wang Bing-Yan , Xiu Dian-Rong 
Published: October 2022

Background and objectiveGastric cancer (GC) represents a major factor inducing global cancer-associated deaths, but specific biomarkers and therapeutic targets for GC are lacking at present. Therefore, the present work focused on developing an immune-related genetic signature at the single-cell level for categorizing GC cases and predicting patient prognostic outcome, immune status as well as treatment response.MethodsSingle-cell RNA-sequencing (scRNA-seq) data were combined with bulk RNA-seq data in GC patients for subsequent analyses. Differences in overall survival (OS), genomic alterations, immune status, together with estimated immunotherapeutic outcomes were measured between different groups.ResultsNine cell types were identified by analyzing scRNA-seq data from GC patients, and marker genes of immune cells were also selected for subsequent analysis. In addition, an immune-related signature was established to predict OS while validating the prediction power for GC patients. Afterwards, a nomogram with high accuracy was constructed for improving our constructed signature’s clinical utility. The low-risk group was featured by high tumor mutation burden (TMB), increased immune activation, and microsatellite instability-high (MSI-H), which were related to the prolonged OS and used in immunotherapy. By contrast, high-risk group was associated with microsatellite stability (MSS), low TMB and immunosuppression, which might be more suitable for targeted therapy. Meanwhile, the risk score generated by our signature was markedly related to the cancer stem cell (CSC) index. In addition, the immunotherapeutic response prediction accuracy of our signature was validated in an external dataset IMvigor210 cohort.ConclusionA signature was constructed according to scRNA-seq data analysis. The signature-screened low- and high-risk patients had different prognoses, immune statuses and enriched functions and pathways. Such results shed more lights on immune status of GC, prognosis assessment, and development of efficient immunotherapeutic treatments.
The clinical value of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and D-dimer-to-fibrinogen ratio for predicting pneumonia and poor outcomes in patients with acute intracerebral hemorrhage
Authors: Luo Sai , Yang Wen-Song , Shen Yi-Qing , Chen Ping , Zhang Shu-Qiang , Jia Zhen , Li Qi , Zhao Jian-Ting , Xie Peng 
Published: October 2022

BackgroundThis study aimed to investigate the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and D-dimer-to-fibrinogen ratio (DFR) as predictors of pneumonia and poor outcomes in patients with acute intracerebral hemorrhage (ICH).MethodsWe retrospectively examined patients with acute ICH treated in our institution from May 2018 to July 2020. Patient characteristics, laboratory testing data, radiologic imaging data, and 90-day outcomes were recorded and analyzed.ResultsAmong the 329 patients included for analysis, 183 (55.6%) developed pneumonia. Systolic blood pressure, initial hematoma volume, D-dimer concentration, NLR, PLR, DFR, and white blood cell, platelet, neutrophil, and lymphocyte counts at admission were significantly higher in patients who developed pneumonia than in those who did not; however, the Glasgow coma scale (GCS) score at admission was significantly lower in pneumonia patients compared with non-pneumonia patients (all P &lt;0.05). Multivariate logistic regression showed that the NLR and PLR were independent predictors of pneumonia, and the NLR and DFR were independent predictors of poor 90-day outcomes (modified Rankin scale score 4–6).ConclusionThe NLR and PLR were independent predictors of pneumonia and the NLR and DFR were independent predictors of poor 90-day outcomes. The NLR, PLR, and DFR can provide prognostic information about acute ICH patients.