bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upaya Meningkatkan Etika Berbicara Pada Anak-Anak RT 16 RW 25 Perumahan Griya Bukit Jaya Gunung Putri Kabupaten Bogor
Authors: Samosir Astuti , Haryanti Ade Siti , Rejeki Suyekti Kinanthi 
Published: December 2022

Pengabdian kepada Masyarakat yang dilaksanakan di Perumahan Griya Bukit Jaya, Gunung Putri, Kabupaten Bogor. Kegiatan ini bertujuan untuk memberikan pemahaman akan pentingnya etika berbicara pada Anak-anak RT 16 RW 25 Perumahan Griya Bukit Jaya Gunung Putri Kabupaten Bogor. Berdasarkan pengamatan sehari-hari yang dilakukan oleh ketua abdimas serta wawancara informal yang dilakukan terhadap ibu-ibu di RT 16 Perumahan Griya Bukit Jaya, banyak anak-anak yang menggunakan bahasa yang tidak sopan. Hasil kegiatan pengabdian ini sebagai berikut. Pertama, mencari solusi terhadap permasalahan yang dihadapi oleh para ibu, terutama dalam menjaga emosi seorang Ibu di rumah. Seperti yang kita ketahui bahwa waktu anak bersama ibu lebih banyak dibandingkan ayah. Kedua, permasalahan “bel”, disepakati akan memasang CCTV guna menjaga kenyamanan warga terutama yang memiliki bayi. Lalu, pada permasalahan orangtua yang tidak mau diberi saran, sebaiknya dilakukan pendekatan personal terkhusus tetangga samping rumah. Kemudian, anak-anak yang sudah terbiasa mengujarkan kata atau kalimat konteks “dewasa” maka orangtua serta semua warga sepakat memberikan pandangan secara bersama ketika mendengar kata atau kalimat tersebut.
Kata Kunci:Etika Berbicara, Anak-anak, Komunikasi
PENINGKATAN KOMPETENSI GURU SEKOLAH MENENGAH KEJURUAN DI KABUPATEN SUMBA BARAT DAYA
Authors: Limbong Mesta , Sitepu Ied Veda R , Kailola Lisa , Jojor Anita 
Published: December 2022

Pelaksanaan kegiatan pelatihan dalam rangka peningkatan kompetensi guru di SMK Don Bosco, Sumba Barat Daya (SBD) serta guru eksternal berlangsung pada tanggal 26-27 Agustus
2022, di Sekolah SMK Don Bosco, SBD. Tujuan kegiatan adalah (1) sharing pengetahuan dan pengalaman; (2) terpetakannya kemampuan kompetensi guru, (3) dimulainya program peningkatan pengetahuan dan kompetensi mengajar para guru, dan (4) sebagai langkah awal perencanaan pengembangan kompetensi guru di Don Bosco, secara khusus dan di Tambolaka, secara umum. Kegiatan yang dilaksanakan adalah (1) observasi lapangan dan (2) FGD guru. Kompetensi guru, pedagogik, sosial, personal, dan profesional, harus diperkuat dan ditingkatkan. Mengingat lulusan SMK diharapkan dapat masuk ke dunia kerja, pengembangan SDM guru menjadi target prioritas, namun sarpras sementara tidak perlu mendapat perhatian karena secara kuantitas dan kualitas sudah memadai. Pelatihan guru yang diselenggarakan kemudian diarahkan untuk mencakup guru sekitar Tambolaka. Di akhir pelatihan, para guru membentuk forum komunikasi yang diharapkan dapat menjembatani komunikasi dan pencapaian misi pendidikan bersama-sama.
PEMBINAAN WARGA GEREJA BERKAITAN DENGAN AJARAN CALVINISME TENTANG TULIP KHUSUSNYA KONSEP “LIMITED ATONEMENT” DI GEREJA KRISTUS PETAMBURAN JAKARTA
Authors: Jura Demsy , Lesmana Liauw Fidelia , Zalukhu Amirrudin 
Published: December 2022

Pembinaan Warga Gereja adalah sebuah kegiatan gereja yang bertujuan untuk pendewasaan iman anggota gereja, dan dengan pelaksanaan kegiatan ini diharapkan iman jemaat akan mengamalami pertumbuhan menunju kedewasaan hidup sebagai orang percaya. Gereja Kristus Petamburan memandang perlu dilaksanakan pembinaan doktrinal bagi warga gerejanya. Dalam upaya pengembangan pelayanan kegerejaan, dan mempersiapkan warga gereja bagi upaya pendewasaan imannya, maka Gereja Kristus Petamburan menyelenggarakan kegiatan Seri Pembinaan Pentakosta dengan maksud mengajarkan keyakinan teologi Calvinisme kepada anggota jemaat. Pembinaan Warga Gereja berkaitan dengan doktrin Calvinisme ini dianggap penting mengingat banyaknya keyakinan lain yang dapat memberi pengaruh buruk bagi mereka. Istilah TULIP merupakan sesuatu yang penting dalam keyakinan Calvinisme dan hal itu perlu diajarkan, dimana salah satu kajiannya adalah Limited Atonement. Kajian soteriologi Calvinisme menyangkut penebusan terbatas yang ada didalamnya.
Kata Kunci: Pembinaan Warga Gereja, Limited Atonement, dan Teologi Calvinisme
Microprocessor device determining direction of sound to improve technical equipment at weaponry
Authors: Trach I. , Klym H. , Diachok R. , Karbovnyk I. 
Published: December 2022

In this work development of an effective microprocessor device for determining the direction of the sound source with high accuracy and algorithm for calculating directions to the sound source were performed. The basis is a 32-bit STM32 microcontroller, which performs the necessary actions for the implementation of sound processing algorithms by the designed device. Electrical oscillations in analog form at the outputs of three microphones were used as input signals. The received signals are amplified by microphone amplifiers with a software-controlled transmission ratio to the nominal level of ADC operation. The use of such microphone sound amplifier with a software-controlled gain level made it possible to respond sensitively to the sound signal level of the environment and maintain the nominal level of the input signal at the ADC input. This approach made it possible to reduce the level of noise (at a low level of the input signal) and the level of signal distortion (at a powerful signal).
The device proposed in the work includes three remote microphones connected by a cable. The microphone amplifiers of each channel are divided into two parts. The first is placed near the microphone and converts the output signal into a differential signal with low internal resistance, the second is placed inside the device itself and converts the differential input signals into a normal form, removing interference of the common type. The amplifiers of the second part of the microphone amplifiers are software controlled, which allows adjustment to the nominal levels required by the ADC inputs. This design uses a built-in MCU ADC, which allows easy conversion of analog signals into digital form and process them according to the necessary algorithms. The obtained results are displayed on the display panel and transmitted over the Ethernet channel for further analysis. The full functioning of the device requires an autonomous power source to provide energy to all nodes.
The developed microprocessor device for determining the direction to the sound source can be used for military purposes with the joint use of algorithms and approaches to determining the direction proposed by other developers.
Etanercept embedded silk fibroin/pullulan hydrogel enhance cartilage repair in bone marrow stimulation
Authors: Song Xiongbo , Wang Xin , Guo Lin , Li Tao , Huang Yang , Yang Junjun , Tang Zhexiong , Fu Zhenlan , Yang Liu , Chen Guangxing , Chen Cheng , Gong Xiaoyuan 
Published: December 2022

Background: Bone marrow stimulation (BMS) is the most used operative treatment in repairing cartilage defect clinically, but always results in fibrocartilage formation, which is easily worn out and needs second therapy. In this study, we prepared an Etanercept (Ept) embedded silk fibroin/pullulan hydrogel to enhance the therapeutic efficacy of BMS.Methods: Ept was dissolved in silk fibroin (SF)—tyramine substituted carboxymethylated pullulan (PL) solution and enzyme crosslinked to obtain the Ept contained SF/PL hydrogel. The synergistical effect of SF/PL hydrogel and Ept was verified by rabbit osteochondral defect model. The mechanism of Ept in promoting articular cartilage repair was studied on human osteoarthritic chondrocytes (hOACs) and human bone marrow mesenchymal stromal cells (hBMSCs) in vitro, respectively.Results: At 4 and 8 weeks after implanting the hydrogel into the osteochondral defect of rabbit, histological analysis revealed that the regenerated tissue in Ept + group had higher cellular density with better texture, and the newly formed hyaline cartilage tissue was seamlessly integrated with adjacent native tissue in the Ept + group. In cellular experiments, Ept treatment significantly promoted both gene and protein expression of type II collagen in hOACs, while decreased the protein levels of metalloproteinase (MMP)-13 and a disintegrin and metalloprotease with thrombospondin motifs 5 (ADAMTS5); alcian blue staining, type II collagen and aggrecan stainings showed that addition of Ept significantly reversed the chondrogenesis inhibition effect of tumor necrosis factor alpha (TNF-α) on hBMSCs.Conclusion: BMS could be augmented by Ept embedded hydrogel, potentially by regulating the catabolic and anabolic dynamics in adjacent chondrocytes and enhancement of BMSCs chondrogenesis.
Inter-hospital transfer in patients with acute myocardial infarction in China: Findings from the improving care for cardiovascular disease in China-acute coronary syndrome project
Authors: Hu Danqing , Hao Yongchen , Liu Jun , Yang Na , Yang Yiqian , Sun Zhaoqing , Zhao Dong , Liu Jing 
Published: December 2022

BackgroundLittle is known about the current scenario of inter-hospital transfer for patients with acute myocardial infarction (AMI) in China.MethodsFrom November 2014 to December 2019, 94,623 AMI patients were enrolled from 241 hospitals in 30 provinces in China. We analyzed the pattern of inter-hospital transfer, and compared in-hospital treatments and outcomes between transferred patients and directly admitted patients.ResultsOf these patients, 40,970 (43.3%) were transferred from hospitals that did not provide percutaneous coronary intervention (PCI). The proportion of patients who were transferred from non-PCI hospital was 46.3% and 11.9% (P &lt; 0.001) in tertiary hospitals and secondary hospitals, respectively; 56.2% and 37.3% (P &lt; 0.001) in hospitals locating in low-economic regions and affluent areas, respectively. Compared with directly admitted patients, transferred patients had lower rates of reperfusion for STEMI (57.8% vs. 65.2%, P &lt; 0.001) and timely PCI for NSTEMI (34.7%vs. 41.1%, P &lt; 0.001). The delay for STEMI patients were long, with 6.5h vs. 4.5h from symptom onset to PCI for transferred and directly admitted patients, respectively. The median time-point was 9 days for in-hospital outcomes. Compared with direct admission, the hazard ratios and 95% confidence intervals associated with inter-hospital transfer were 0.87 (0.75–1.01) and 0.87 (0.73–1.03) for major adverse cardiovascular events and total mortality, respectively, in inverse probability of treatment weighting models in patients with STEMI, and 1.02 (0.71–1.48) and 0.98 (0.70–1.35), respectively, in patients with NSTEMI.ConclusionMore than 40% of the hospitalized AMI patients were transferred from non-PCI-capable hospitals in China. Further strategies are needed to enhance the capability of revascularization and reduce the inequality in management of AMI.
Microbiome alterations in women with gestational diabetes mellitus and their offspring: A systematic review
Authors: Farhat Sara , Hemmatabadi Mahboobeh , Ejtahed Hanieh-Sadat , Shirzad Nooshin , Larijani Bagher 
Published: December 2022

AimsGestational diabetes mellitus (GDM) is a metabolic disorder that might predispose pregnant women to develop type 2 Diabetes Mellitus or lead to severe adverse outcomes in their offspring. One of the factors that have been thought to be involved in the pathology behind this disorder is the microbiome. In this systematic review, we comprehensively review the documents regarding the microbiota alterations in different tracts of pregnant women with GDM and their offspring.MethodsA comprehensive search was conducted in major databases including MEDLINE (PubMed), Scopus, and Web of sciences up to August 2021. Data on the demographics, methodology, and microbiome alterations were extracted and classified according to the type of microbiome in pregnant women with GDM and their offspring. The quality of studies was assessed using the Newcastle-Ottawa Scale (NOS).ResultsIn 49 articles which were retrieved, the findings were variable on the level of changes in alpha and beta diversity, enrichment or depletion in phyla, genera, species and OTUs, in each microbiome type. Although there were some inconsistencies among the results, a pattern of significant alterations was seen in the gut, oral, vaginal microbiome of women with GDM and gut, oral, and placental microbiome of their offspring.ConclusionEven though the alteration of the microbiome of the different tracts was seen in the cases of GDM, the inconsistency among the studies prevents us from identifying unique pattern. However, the results seem promising and further studies that overcome the confounding factors related to the demographics and methodology are needed.
Characteristics and physical mechanisms of a rainstorm in Hotan, Xinjiang, China
Authors: Yin Gang , Zhang Zhuo , Zhu Bojun , Li Qingxiang , Mao Min , Xing Wenyuan , Hu Zengyun , Chen Xi 
Published: December 2022

Owing to global warming, extreme precipitation events in the arid regions of Central Asia have increased, resulting in significant consequences for water resources and ecosystems. Hence, to address the features and corresponding physical mechanisms of these rainstorms, we examined the rainstorm that occurred in Hotan, Xinjiang in June 2021 as a case study. We employed multiple datasets, including meteorological stations, sounding observations, satellite precipitation data, and reanalysis datasets. The results indicate that the Global Precipitation Measurement satellite precipitation product accurately captured the temporal and spatial variations in this rainstorm, as verified against hourly in situ observation data. Some meteorological stations recorded values greater than twice their historical records, such as Luopu, Pishan, Moyu, and Hotan. Moreover, the duration of the precipitation was longer than 2 days. For the physical mechanisms of this rainstorm, the water vapor in this rainstorm is sourced from the 45°–65°N region of the North Atlantic Ocean crosses the Ural Mountains and the West Siberian Plain to southern Xinjiang. The low-pressure levels (e.g., 700 hPa and 850 hPa) have the more water vapor flux and specific humidity than the high-pressure levels. Our findings can aid the understanding of extreme precipitation events in Central Asia and provide a reference for dealing with meteorological disasters, including extreme precipitation, in the context of global climate change.
Modelling the nexus of carbon dioxide emissions, economic growth, electricity production and consumption: Assessing the evidence from Pakistan
Authors: Ali Sajjad , Ghimire Amogh , Khan Adnan , Tariq Gulzara , Shah Ashfaq Ahmad , Tariq Muhammad Atiq Ur Rehman 
Published: December 2022

The economy of Pakistan has constantly been plunged due to its severe electricity shortages over the last 2 decades and persistently faces challenges in revamping its electricity supply network. The purpose of this research was to assess the causal relationship between carbon dioxide emissions (CO2), combustible renewable and waste (CRW), electric power consumption (EC), electricity production from coal (EPC), hydroelectric (EPH) and natural gas (EPN) sources, energy use (EU) and gross domestic product (GDP). The scope of this research included Pakistan’s annual time series data from 1971 to 2014. This study employed Autoregressive Distributed Lag (ARDL) bound testing analysis to determine the long-term and short-term correlations among all research parameters. This research also conducted Augmented Dickey-Fuller (ADF), Phillips-Perron (PP) and Kwiatkowski-Phillips-Schmidt-Shin (KPSS) tests to evaluate the stationarity existence among dependent variable and independent variables. The outcomes of the fully modified least squares (FMOLS), dynamic ordinary least square (DOLS) and canonical co-integrating regression (CCR) estimators showed that coefficients of EC, EPH and GDP all were a significantly positive relationship with CO2 emissions, while the coefficients of CRW, EPC and EU were negatively significant, respectively. Furthermore, the outcomes from the short-run analysis revealed that the error correction term value was -0.8668, which indicates that from short-run to long-run equilibrium, the adjustment of the deviation of CO2 emission is by 86.68 percent annually. Moreover, the diagnostic results also demonstrated that the model employed in this research is stable and reliable. Pakistan was selected in this research work because of the deficit of power and if environmental degradation continues unchecked, it will eventually affect the state’s economic growth and CO2 emissions. The study’s primary policy recommendation is that government energy policymakers in Pakistan who create the environment framework in should pursue conservative energy measures as such measures will not negatively impact economic growth.
Identification of necroptosis subtypes and development of necroptosis-related risk score model for in ovarian cancer
Authors: Ji Chen , He Yue , Wang Yan 
Published: December 2022

Background: ith the ongoing development of targeted therapy, non-apoptotic cell death, including necroptosis, has become a popular topic in the field of prevention and treatment. The purpose of this study was to explore the effect of necroptosis-related genes (NRGs) on the classification of ovarian cancer (OV) subtypes and to develop a necroptosis-related risk score (NRRS) classification system.Methods: 74 NRGs were obtained from the published studies, and univariate COX regression analysis was carried out between them and OV survival. Consensus clustering analysis was performed on OV samples according to the expression of NRGs related to prognosis. Furthermore, the NRRS model was developed by combining Weighted Gene Co-Expression Network Analysis (WGCNA) with least absolute shrinkage and selection operator (Lasso)-penalized Cox regression and multivariate Cox regression analysis. And the decision tree model was constructed based on the principle of random forest screening factors principle.Results: According to the post-related NRGs, OV was divided into two necroptosis subtypes. Compared with Cluster 1 (C1), the overall survival (OS) of Cluster 2 (C2) was significantly shorter, stromal score and immune score, the infiltration level of tumor associated immune cells and the expression of 20 immune checkpoints were significantly higher. WGCNA identified the blue module most related to necroptosis subtype, and 12 genes in the module were used to construct NRRS. NRRS was an independent prognostic variable of OV. The OS of samples with lower NRRS was significantly longer, and tumor mutation burden and homologous recombination defect were more obvious.Conclusion: This study showed that necroptosis plays an important role in the classification, prognosis, immune infiltration and biological characteristics of OV subtypes. The evaluation of tumor necroptosis may provide a new perspective for OV treatment.
Impact of Kawasaki disease on juvenile idiopathic arthritis in real-world patients: A population-based cohort study
Authors: Liao Li-Chin , Fu Yi-Hsiu , Chuang Chieh-Mao , Liao Pei-Lun , Wei James Cheng-Chung , Fu Yun-Ching 
Published: December 2022

ObjectivesRecent research has demonstrated the commonality of several biological markers between Kawasaki disease (KD) and juvenile idiopathic arthritis (JIA), including interleukin-1β and -6. Therefore, in this cohort study, we assessed whether KD increases the risk of JIA.MethodsThis study enrolled 7009 patients with and 56 072 individuals without KD in the period 2010–2018 from Taiwan’s National Health Insurance Research Database. On the basis of sex, age, and comorbidities, we executed propensity score matching at the ratio 1:8. The adjusted hazard ratio (aHR) for JIA was determined through multiple Cox regression. Stratified analysis and sensitivity tests were also employed.ResultsWhen adjusting for age, sex, and comorbidities, the JIA risk was noted to be 2.02-fold greater in children with KD than it was in those without (aHR: 2.02, 95% confidence interval: 1.12–3.67, p = 0.0205). The sensitivity test and subgroup analysis obtained consistent findings in the different sex and comorbidity subgroups.ConclusionChildren’s risk of JIA is higher if they have KD. Pediatricians should consider the possibility of JIA in this population. More investigations are necessary to identify the pathological mechanisms that link JIA and KD.
Overnutrition-induced gout: An immune response to NLRP3 inflammasome dysregulation by XOD activity increased in quail
Authors: Wu Hao , Wang Yu , Ren Zhixin , Li Yaolei , Huang Jingjian , Lin Zhijian , Zhang Bing 
Published: December 2022

BackgroundGout is a progressive metabolic disease closely related to hyperuricemia and urate deposition, with an increasing prevalence and incidence across the globe. Recent studies have shown that the pathological process of gout includes two stages: asymptomatic hyperuricemia and MSU crystal deposition. However, the immune response during the development of hyperuricemia to gouty arthritis is not fully elucidated.MethodsThus, an overnutrition-induced whole-course gout model was established to clarify the immune response and pathological changes in the development from hyperuricemia to gouty arthritis. The quails without urate oxidase were used as experimental animals. And we confirmed that uric acid metabolic targets were changed when quails were in the asymptomatic hyperuricemia stage. ResultsWhen the quail showed gout symptoms, the NLRP3 inflammasome was activated, and the expressions of IL-1β, TNF-α, IL-6, IL-8, and IL-18 were significantly increased. The relationship between the uric acid metabolism target and the NLRP3 inflammasome may be the critical immune response between hyperuricemia and gouty arthritis. Our data showed that, in the process of gout disease, the expression of xanthine oxidase (XOD) has been increasing, which increases the level of uric acid, disrupts the balance of oxidative stress, generates a large amount of ROS, activates the NLRP3 inflammasome, and release IL-1β. Treatment with the XOD inhibitor can reduce uric acid, restore the body’s degree of peroxidative damage and antioxidant capacity, and inhibit NLRP3 inflammasome and IL-1β. In vitro, we extracted and identified primary fibroblast-like synoviocytes (FLS) from quail for the first time. Stimulating FLS with uric acid also caused ROS release and NLRP3 inflammasome activation. However, treatment with an XOD inhibitor prevented all these responses in FLS. ConclusionOur results indicate that the immune response between the uric acid metabolism target XOD and NLRP3 inflammasomes plays a crucial role in developing hyperuricemia to gouty arthritis, and inhibition of both XOD and NLRP3 inflammasomes may be an effective treatment for avoiding the development of asymptomatic hyperuricemia to MSU crystal deposition. Meanwhile, this study also provides an advantageous animal model for pathological mechanisms and research and development drugs for gout.