bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffusion-Weighted Imaging and Fluid-Attenuated Inversion Recovery Quantification to Predict Diffusion-Weighted Imaging-Fluid-Attenuated Inversion Recovery Mismatch Status in Ischemic Stroke With Unknown Onset
Authors: Scheldeman Lauranne , Wouters Anke , Dupont Patrick , Christensen Søren , Boutitie Florent , Cheng Bastian , Ebinger Martin , Endres Matthias , Fiebach Jochen B. , Gerloff Christian , Muir Keith W. , Nighoghossian Norbert , Pedraza Salvador , Simonsen Claus Z. , Thijs Vincent , Thomalla Götz , Lemmens Robin 
Published: February 2022

Background:
Visual rating of diffusion-weighted imaging (DWI)–fluid-attenuated inversion recovery (FLAIR) mismatch can be challenging. We evaluated quantification of DWI and FLAIR to predict DWI-FLAIR mismatch status in ischemic stroke.

Methods:
In screened patients from the WAKE-UP trial (Efficacy and Safety of Magnetic Resonance Imaging-Based Thrombolysis in Wake-Up Stroke), we retrospectively studied relative DWI (rDWI SI) and FLAIR signal intensity (rFLAIR SI). We defined the optimal mean rFLAIR SI and interquartile range of the rDWI SI in the DWI lesion to predict DWI-FLAIR mismatch status. We investigated agreement between each quantitative parameter and the DWI-FLAIR mismatch and the association between both quantitative parameters. We evaluated the predictive value of the quantitative parameters for excellent functional outcome by logistic regression, adjusted for DWI lesion volume, treatment, age, and National Institutes of Health Stroke Scale score.

Results:

In the rFLAIR and rDWI SI analysis, 213/369 and 241/421 subjects respectively had a DWI-FLAIR mismatch. A mean rFLAIR SI cutoff of 1.09 and interquartile range rDWI SI cutoff of 0.47 were optimal to predict the DWI-FLAIR mismatch with a sensitivity and specificity of 77% (95% CI, 71%–83%) and 67% (95% CI, 59%–74%), and 76% (95% CI, 70%–81%) and 72% (95% CI, 65%–79%), respectively. For both quantitative parameters, agreement with the DWI-FLAIR mismatch was fair (73%, κ=0.44 [95% CI, 0.35–0.54] for rFLAIR and 74%, κ=0.48 [95% CI, 0.39–0.56] for rDWI). Both quantitative parameters correlated moderately (Pearson R=0.54 [95% CI, 0.46–0.61];
P
<0.001, n=367). The interquartile range rDWI SI (n=188), but not the mean rFLAIR SI (n=172), was an independent predictor of excellent functional outcome (odds ratio, 0.67 per 0.1 unit increase of interquartile range rDWI SI, 95% CI, 0.51–0.89,
P
=0.01).

Conclusions:
Agreement between the quantitative and qualitative approach may be insufficient to advocate DWI or FLAIR quantification as alternative for visual rating.
Global Snowmelt Onset Reflects Climate Variability: Insights from Spaceborne Radiometer Observations
Authors: Zheng Lei , Cheng Xiao , Chen Zhuoqi , Wang Shaoyin , Liang Qi , Wang Kang 
Published: February 2022

AbstractSnowmelt is a critical component in the cryosphere and has a direct impact on Earth’s energy and water budget. Here, a 40-yr integrated melt onset (MO) dataset over sea ice, ice sheets, and terrestrial snow is compiled from spaceborne microwave radiometers and ERA5, allowing an overall assessment of the cryosphere. Results suggest that MO in both hemispheres shows latitudinal and vertical zonalities. The global cryosphere presented a trend toward earlier MO (−2 days decade−1) with hotpots distributed at the Northern Hemisphere high latitudes where the warming rate is much higher than that at lower latitudes. Overall, variations in MO showed a similar pattern to that in near-surface temperature. The advance of MO has been slowing down since the 1990s and no significant trend was observed during the so-called warming hiatus period (1998–2012). Regionally, climatic linkage analyses suggest the local MO variations were associated with different climate indices. MO in the pan-Arctic region is related with the Arctic Oscillation and North Atlantic Oscillation, while that in the pan-Antarctic region is associated with El Niño–Southern Oscillation and the southern annular mode. Occasionally, abnormal MO occurs as a result of extreme weather conditions. In February 2018, abnormal early melt events that occurred in the Arctic Ocean are found to be linked with the warm southerly flow due to sudden stratospheric warming. These findings suggest the satellite-based MO allows examining the dynamics and extremes in the climate system, both regionally and globally.
Deep Lagrangian Connectivity in the Global Ocean Inferred from Argo Floats
Authors: Abernathey Ryan , Bladwell Christopher , Froyland Gary , Sakellariou Konstantinos 
Published: February 2022

AbstractThe connectivity between ocean basins and subbasin regions strongly influences the transport of ocean tracers and thus plays a role in regulating climate and ocean ecosystems. We describe the application of a new technique from nonlinear dynamical systems to infer the Lagrangian connectivity of the deep global ocean. We approximate the dynamic Laplacian using Argo trajectories from January 2011 to January 2017 and extract the eight dominant coherent (or dynamically self-connected) regions at 1500 m depth. Our approach overcomes issues such as sparsity of observed data and floats continually leaving and entering the dataset; only 10% of floats record continuously for the full six years. The identified coherent regions maximally trap water within them over the six-year time frame, providing a distinct analysis of the deep global ocean and relevant information for planning future float deployment. A key result is that the coherent regions are highly stationary, showing minimal displacement over the six-year period. Although our study is concerned with ocean circulation at a multiyear, global scale, the dynamic Laplacian approach may be applied at any temporal or spatial scale to identify coherent structures in ocean flow from positional time series information arising from observations or models.
Association Between Negative Affectivity and Craving in Substance-Related Disorders: A Systematic Review and Meta-analysis of Direct and Indirect Relationships
Authors: Cyr Laura , Bernard Laura , Pedinielli Jean-Louis , Cutarella Christophe , Bréjard Vincent 
Published: February 2022

Background A sizeable literature highlighted that negative affectivity and craving are both known to be implicated in relapses. Objectives The present study synthetized the existing litterature to determine strength of the interaction between negative affectivity and craving for substance-related disorders including illicit drugs, alcohol and tobacco. Methods We conducted a systematic review in accordance with PRISMA guidelines followed by a meta-analysis. Online computer databases PubMed, PsycINFO and Web of Science were searched systematically and thoroughly. Jamovi 1.8.1 Current version was used to conduct meta-analysis. Results Thirty studies were included in the review, and 14 of these, including 2257 subjects, were used for meta-analysis. The raw correlation ranged from 0.17 to 0.58, which indicated weak to moderate association between negative affects and craving. In total, approximately 90% of the selection revealed a positive correlation between negative affects and craving. Alcohol and tobacco use disorders have received the most attention. Additionally, negative affectivity was often defined as a transient state rather than a stable personality trait. Conclusions In both of our meta-analyses and in the narratively reported studies, we found that negative affectivity is an important component related to craving, but individual differences in craving reactivity existed.
Green compounds of SBR with nanofibrilated cellulose and palm oil in replacement to traditionally compounds used
Authors: Ribeiro Willian B , Damo Thamires , Zattera Ademir J , Brandalise Rosmary N 
Published: February 2022

Silica and carbon black (CB) are the most used reinforcement fillers in elastomeric compositions; however, their obtention and usage might result in environmental and human health damages. The same happens to the plasticizers used in elastomeric compounds, which contain a high content of polycyclic aromatics. To use reinforcement and plasticizer loads from natural sources, the performance of an elastomeric compound by partially replacing CB with nanofibrillated cellulose (CEL) provided with Eucalyptus spp. shavings was evaluated in this work, as well as, the use of palm oil to replace aromatic oils. Nanofibrilated cellulose was obtained by grinding in a micronizing mill. As a characterization of the raw material, the thermal, chemical and morphological properties, as well as particle size analysis of the cellulose suspension were evaluated by the particle size analyzer. From the vulcanized material, the physical, mechanical, dynamic-mechanical properties, cross-link density, and swelling index in solvents were evaluated. As the main results obtained, the presence of CEL clusters seen by scanning electron microscopy with nanofibers with diameters of 100–85 nm was observed. The dynamic light scattering particle size analyzers (DLS) showed nanoparticles from 1 to 100 nm. The rheometric properties showed lower values for the parameters of safety time, optimal vulcanization time, and maximum and minimum torques when compared to samples with CEL as CB. For tear resistance properties, samples with the presence of nanofibrilated cellulose showed 48% more resistance than samples with CB, in the modulus of elasticity, cross-link density, and swelling index, a better performance was also achieved for the samples with CEL, along with presenting a similar behavior in the hardness property between samples with the presence of nanofibrillates and those with CB. Palm oil, a substitute for aromatic oil, was found to be similar in the evaluated properties results, with interaction with CEL, by chemical affinity, which can replace aromatic oil.
The association of three anatomical factors with ulnar-sided wrist pain: a radiological study
Authors: Wang Jiangtao , Yin Yu , Sun Cheng , Wu Ruimin , Luo Tao , Che Jianwei , Bu Jianli 
Published: February 2022

Background Ulnar-sided wrist pain is associated with the development of multiple wrist pathologies. But the anatomical etiologies have not been fully understood. Purpose To determine the association of three anatomical factors with ulnar-sided wrist pain, including ulnar variance (UV), distal ulnar volar angle (DUVA), and pisiform-ulnar distance (PUD). Material and Methods A total of 64 patients who had ulnar-sided wrist pain associated with training injuries were retrospectively studied. A control group included 64 healthy athletes from the same unit. The UV, DUVA, and PUD of each individual was measured on radiographs. Results The average UV and DUVA of those in the ulnar-sided pain group were 0.84 mm and 174.65°, respectively; the control group values were 0.39 mm and 175.11°. The differences between the two groups had no statistical significance ( P > 0.05). The average PUD of the ulnar-sided wrist pain group was shorter than that of the control group (2.37 cm vs. 2.65 cm); the difference had statistical significance ( P < 0.05). PUD had a negative correlation with ulnar-sided pain; it was an anatomical protective factor (odds ratio = 0.01; P < 0.00; 95% confidence interval=0.00–0.05). Both UV and DUVA had no significant correlations with ulnar-sided wrist pain ( P > 0.05). Conclusion PUD has a significant correlation with ulnar-sided wrist pain. It is the anatomical protective factor. Both the UV and DUVA have no statistical association with ulnar-sided wrist pain, but we cannot ignore their potential pathogenic effects on wrists, and further studies are needed to confirm the results.
Narrative medicine: feasibility of a digital narrative diary application in oncology
Authors: Cercato Maria Cecilia , Colella Elvira , Fabi Alessandra , Bertazzi Isabella , Giardina Barbara Giuseppa , Di Ridolfi Paolo , Mondati Mara , Petitti Patrizia , Bigiarini Liciano , Scarinci Virginia , Franceschini Alessandro , Servoli Francesca , Terrenato Irene , Cognetti Francesco , Sanguineti Giuseppe , Cenci Cristina 
Published: February 2022

Objectives We implemented narrative medicine in clinical practice using the Digital Narrative Medicine (DNM) platform. Methods We conducted a preliminary, open, uncontrolled, real-life study in the oncology and radiotherapy departments of Istituto di Ricovero e Cura a Carattere Scientifico National Cancer Institute Regina Elena, Rome, Italy. We recruited adult Italian-speaking patients who then completed the DNM diary from the start of treatment. The primary endpoint was DNM feasibility; secondary endpoints were health care professionals’ opinions about communication, therapeutic alliance, and information collection and patients’ opinions about therapeutic alliance, awareness, and coping ability. We used open- and closed-ended questions (scores 1 to 5) and a structured interview. Results Thirty-one patients (67%) used the diary (84% women). Health care professionals’ mean scores for feasibility and utility were ≥4.0. Patients’ utility scores were related to health care professionals’ feedback regarding the narratives. The main advantages for health care professionals were the opportunity to obtain relevant patient data and to strengthen communication and patient relationships (mean scores 4.4–5.0). Both groups strongly encouraged introduction of the diary in clinical practice. Conclusion Use of the DNM in oncology patients assisted clinicians with understanding their patients experience.
COVID-19 and job demands and resources experienced by nurses in Sri Lanka
Authors: Wanninayake Shalini Dananja , O’Donnell Michael , Williamson Sue 
Published: February 2022

AbstractSri Lanka has a history of successfully managing communicable diseases by utilising its extensive public healthcare network of community clinics and public hospitals. This article makes use of Job Demands-Resources theory (JD-R) to examine the impact of COVID-19 on nurses’ working conditions in public and private hospitals in Sri Lanka. Prior to the COVID-19 pandemic, nurses’ job demands on public hospital wards included long working hours, limited workplace autonomy, minimal medical resources and high workloads caused by understaffing. Private hospital nurses experienced pressure from patients and their families to provide them with discounts on medical bills. Nurses allocated to work on COVID-19 wards experienced additional physical job demands from wearing personal protective equipment (PPE) for lengthy periods on hospital wards in a humid climate. Nurses on COVID-19 wards also experienced increased anxiety that they could transmit the disease to family members. While nurses experienced job resources such as social support from nursing supervisors and other nurses, they reported receiving minimal training in the provision of healthcare to COVID-19 patients. This combination of high job demands and low job resources increased the levels of exhaustion and mental distress experienced by many nurses working on COVID-19 hospital wards.
Three heads are better than one: Psychiatry trainees’ experiences of a psychotherapy written case supervision group with three co-supervisors
Authors: Matta Gabrielle , Ryan Tom , Hartman David 
Published: February 2022

Objective The aim of this project was to evaluate the experiences of Royal Australian and New Zealand College of Psychiatrists (RANZCP) trainees in a regional centre who participated in a psychodynamic psychotherapy written case supervision group with three co-supervisors. Method A web-based survey was sent to RANZCP trainees. Descriptive statistics were performed, and written feedback was analysed. Results A total of 8 of 10 eligible trainees completed the survey. All respondents stated that the group met their training needs. The average rating of feeling understood by supervisors was 91 (maximum 100). Positive feedback was received about the variety and breadth of experience provided by the co-supervisors. Trainees felt that 1:1 supervision was important to complement group supervision. Conclusions The supervision group model with three co-supervisors is competently meeting the training needs of RANZCP trainees as well as providing a deep learning experience. This model may be of use in other services, particularly in regional settings.
Clinical Efficacy and Safety of Fanhdi®, a Plasma-Derived VWF/Factor VIII Concentrate, in von Willebrand Disease in Spain: A Retrospective Study
Authors: Jiménez-Yuste Víctor , Alvarez-Román María Teresa , Palomo Bravo Ángeles , Galmes Bernardo J. , Nieto Hernández Maria del Mar , Benítez Hidalgo Olga , Marzo Alonso Cristina , Pérez González Noelia Florencia , Coll Julia , Núñez Ramiro , Carrasco Marina , García Candel Faustino , Gonzalez-Porras Jose Ramon , Hernández García Carmen , Varó Castro Maria José , Mir Roser 
Published: February 2022

Objective To evaluate the efficacy and safety of a plasma-derived factor VIII concentrate containing von Willebrand Factor (pdVWF/FVIII) in standard clinical practice in von Willebrand Disease (VWD) patients. Methods A retrospective, multicentric, observational study of VWD patients treated with Fanhdi®, a pdVWF/FVIII concentrate, from January 2011 to December 2017 was conducted at 14 centers in Spain. Efficacy and safety were evaluated for acute bleeding episodes, for prevention of bleeding in surgeries, and for secondary long-term prophylaxis. Results Seventy-two eligible patients, type 1, 2, 3 VWD (25%/38.9%/36.1%) were treated for spontaneous and traumatic bleeding (140 episodes, n = 41 patients), to prevent surgical bleeding (69 episodes, n = 43 patients); and for secondary long-term prophylaxis (18 programs, n = 13 patients). Replacement therapy with pdVWF/FVIII showed an excellent to good clinical efficacy in 96.7% of the bleeding episodes, 100% during surgical procedures and 100% during prophylaxis. No adverse events (AEs), nor serious AEs related to the product were observed. Conclusions Fanhdi® was effective, safe and well tolerated in the management of bleeding episodes, the prevention of bleeding during surgeries, and for secondary long-term prophylaxis in VWD patients.
Immunohistochemical markers to diagnose primary squamous cell carcinoma of the lung: a meta-analysis of diagnostic test accuracy
Authors: Chen Hao , Katakura Seigo , Horita Nobuyuki , Namkoong Ho , Kato Ikuma , Hara Yu , Kobayashi Nobuaki , Fujii Satoshi , Kaneko Takeshi 
Published: February 2022

Background: Inconsistent diagnostic test accuracies of immunohistological staining for squamous cell carcinoma (SQC) of the lung have been frequently reported. There have been few meta-analyses of the diagnostic accuracies of the immunohistochemical markers. Methods: A systematic review and meta-analysis were performed following standard guidelines for systematic reviews of diagnostic test accuracy. Immunohistochemical markers (p40, p63, CK5/6, and DSC3) were evaluated as index tests for SQC. The diagnostic odds ratio (DOR) was obtained by the DerSimonian–Laird variate model. Summary estimates of sensitivity and specificity were calculated using a bivariate model. The protocol registration ID is UMIN000041664. Results: The meta-analysis included 85 of the 1353 first-screened articles. The total number of patients was 17,893, which consisted 6151 SQC cases and 11,742 non-squamous non-small-cell lung cancer cases. The DOR was better for p40 (377, 95% confidence interval (CI) = 213–644, I2 = 0%) than for CK5/6 (120, 95% CI = 78–184, I2 = 2.5%), p63 (70, 95% CI = 55–88, I2 = 9.1%), and DSC3 (94, 95% CI = 35–250, I2 = 3.7%). Summary estimates of sensitivity and specificity were followings: p40 sensitivity 0.92 (95% CI = 0.89–0.95), specificity 0.94 (95% CI = 0.93–0.96); p63 sensitivity 0.92 (95% CI = 0.90–0.94), specificity 0.83 (95% CI = 0.80–0.86); CK5/6 sensitivity 0.90 (95% CI = 0.87–0.93), specificity 0.91 (95% CI = 0.89–0.93); DSC3 sensitivity 0.81 (95% CI = 0.73–0.88), and specificity 0.95 (95% CI = 0.85–0.98). Conclusion: P40 had the best DOR to diagnose SQC in non-small-cell lung carcinoma. Despite its lower sensitivity, DSC3 had the best specificity among the four markers and might be useful to rule-in the diagnosis of SQC.
Integration of new digital antenatal care tools using the WHO SMART guideline approach: Experiences from Rwanda and Zambia
Authors: Muliokela Rosemary , Uwayezu Gilbert , Tran Ngoc Candide , Barreix María , Tamrat Tigest , Kashoka Andrew , Chizuni Caren , Nyirenda Muyereka , Ratanaprayul Natschja , Malumo Sarai , Mutabazi Vincent , Mehl Garrett , Munyana Edith , Sayinzoga Felix , Tunçalp Özge 
Published: February 2022

ObjectivesDigital tools for decision-support and health records can address the protracted process of guideline adoption at local levels and accelerate countries’ implementation of new health policies and programmes. World Health Organization (WHO) launched the SMART Guidelines approach to support the uptake of clinical, public health, and data recommendations within digital systems. SMART guidelines are a package of tools that include Digital Adaptation Kits (DAKs), which distill WHO guidelines into a format that facilitates translation into digital systems. SMART Guidelines also include reference software applications known as digital modules.MethodsThis paper details the structured process to inform the adaptation of the WHO antenatal care (ANC) digital module to align with country-specific ANC packages for Zambia and Rwanda using the DAK. Digital landscape assessments were conducted to determine potential integrations between the ANC digital module and existing systems. A multi-stakeholder team consisting of Ministry of Health technical officers representing maternal health, HIV, digital health, and monitoring and evaluation at district and national levels was assembled to review existing guidelines to adapt the DAK.ResultsThe landscape analysis resulted in considerations for integrating the ANC module into the broader digital ecosystems of both countries. Adaptations to the DAK included adding national services not reflected in the generic DAK and modification of decision support logic and indicators. Over 80% of the generic DAK content was consistent with processes for both countries. The adapted DAK will inform the customization of country-specific ANC digital modules.ConclusionBoth countries found that coordination between maternal and digital health leads was critical to ensuring requirements were accurately reflected within the ANC digital module. Additionally, DAKs provided a structured process for gathering requirements, reviewing and addressing gaps within existing systems, and aligning clinical content.