bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neoadjuvant Nivolumab Plus Ipilimumab and Adjuvant Nivolumab in Localized Deficient Mismatch Repair/Microsatellite Instability–High Gastric or Esophagogastric Junction Adenocarcinoma: The GERCOR NEONIPIGA Phase II Study
Authors: André Thierry , Tougeron David , Piessen Guillaume , de la Fouchardière Christelle , Louvet Christophe , Adenis Antoine , Jary Marine , Tournigand Christophe , Aparicio Thomas , Desrame Jérôme , Lièvre Astrid , Garcia-Larnicol Marie-Line , Pudlarz Thomas , Cohen Romain , Memmi Salomé , Vernerey Dewi , Henriques Julie , Lefevre Jérémie H. , Svrcek Magali 
Published: August 2022

PURPOSE In patients with resectable gastric/gastroesophageal junction (GEJ) adenocarcinoma, surgery plus perioperative platinum-based chemotherapy is the standard of care. Perioperative chemotherapy remains debatable for gastric/GEJ adenocarcinoma with deficient mismatch repair (dMMR)/microsatellite instability–high (MSI-H). PATIENTS AND METHODS NEONIPIGA (ClinicalTrials.gov identifier: NCT04006262 ) phase II study evaluated neoadjuvant nivolumab 240 mg once every two weeks ×6 and ipilimumab 1 mg/kg once every six weeks ×2, followed by surgery and adjuvant nivolumab 480 mg once every four weeks (nine injections) in patients with locally advanced resectable dMMR/MSI-H, clinical (c) tumor (T)2-T4 node (N)x metastasis (M)0 gastric/GEJ adenocarcinoma. The primary end point was a pathological complete response (pCR) rate. RESULTS Between October 2019 and June 2021, 32 patients with dMMR/MSI-H gastric/GEJ adenocarcinoma were enrolled. The median age was 65.5 years (range, 40-80). Clinical stages were cT2-T3N0 (n = 9), cT2-T3N1 (n = 22), and cT3N1M1 (n = 1, wrongly included). With a median follow-up of 14.9 months (95% CI, 10.6 to 17.6), 32 patients received neoadjuvant immunotherapy (27 patients completed all cycles). Neoadjuvant therapy-related grade 3/4 adverse events occurred in six patients (19%). Twenty-nine patients underwent surgery; three did not have surgery and had complete endoscopic response with tumor-free biopsies and a normal computed tomography scan (two refused surgery and one had metastasis at inclusion). The rate of surgical morbidity (Clavien-Dindo classification) was 55% (one postoperative death occurred). All 29 patients had an R0 resection, and 17 (58.6%; 90% CI, 41.8 to 74.1) had pCR (pathological T0N0). Becker tumor regression grades 1a, 1b, 2, and 3 were observed in 17 patients, three (including two pathological T0N1), two, and seven patients, respectively. Of the 29 patients with surgery, 23 received adjuvant nivolumab. At database lock, no patient had relapse and one died without relapse. CONCLUSION Nivolumab and ipilimumab-based neoadjuvant therapy is feasible and associated with no unexpected toxicity and a high pCR rate in patients with dMMR/MSI-H resectable gastric/GEJ adenocarcinoma.
Two-dimensional single-lobe Si photonic optical phased array with
minimal antennas using a non-uniform large spacing array design
Authors: Xue Yulong , Zhang Qihao , Ren Yangming , Lei Yufang , Sun Xiaochen , Zhang Lingxuan 
Published: August 2022

We report a two-dimensional Si photonic optical phased array (OPA) optimized for a
large optical aperture with a minimal number of antennas while
maintaining single-lobe far field. The OPA chip has an optical
aperture of

∼

200

µ

m

by 150 µm comprising a

9

×

9

antenna array. The two-dimensional
spacings between these antennas are much larger than the wavelength
and are highly non-uniform optimized by the genetic deep learning
algorithm. The phase of each antenna is independently tunable by a
thermo-optical phase shifter. The experimental results validate the
design and exhibit a

0.39

∘

×

0.41

∘

beamwidth within the 3 dB steering
range of

14

∘

×

11

∘

limited by the numerical aperture of
the far-field camera system. The method can be easily extended to a
larger aperture for narrower beamwidth and wider steering range.
Providing ambulatory healthcare for people aged 80 and over: Views and perspectives of physicians and dentists from a qualitative survey
Authors: Herrler Angélique , Valerius Lisa , Barbe Anna Greta , Vennedey Vera , Stock Stephanie 
Published: August 2022

Background
People aged 80 and over frequently face complex chronic conditions and health limitations, including oral health problems, which are primarily addressed by ambulatory (i.e., outpatient) healthcare. This demographic development is expected to affect the provision of care. However, few studies have investigated physicians’ and dentists’ views across the various medical disciplines in non-institutional settings. This study investigated how healthcare providers perceive caring for very old people, and how they feel healthcare should be designed for this patient group.

Methods
A qualitative online survey comprising nine open-ended items was conducted among physicians and dentists practicing in the ambulatory healthcare sector in North Rhine-Westphalia, Germany. Apart from child and adolescent healthcare, no medical specialties were excluded. The results were analysed using Kuckartz’ approach of structuring qualitative content analysis. A descriptive codebook was developed first. After coding all the material, recurring patterns between the topics were investigated and compared between two groups of participants, physicians and dentists.

Results
N = 77 cases were included in the analysis, from which n = 21 originated from the field of ambulatory general practice care and internal medicine, n = 19 from specialties (e.g., neurology, urology), and n = 37 from dentistry. Caring for patients aged 80 and over was perceived as challenging because of complex health conditions and treatments such as multimorbidity and polypharmacy, and patients’ cognitive and physical limitations. In characterizing good care in older age, both groups found individual care important, as well as empathetic interactions and good collaboration in networks of healthcare providers. Inadequate reimbursement and limited resources and time were the most important barriers to providing good care, while one of the most important facilitators was healthcare providers’ attitude and motivation.

Conclusions
Physicians’ and dentists’ conceptions of good healthcare are in line with the conceptualization of patient-centred care. However, the transfer in everyday care delivery is hampered by the current design of healthcare structures. Healthcare providers feel overstrained by the increasing demands placed on them. Adaptations for improvement should focus on building strong networks of cooperating health professions, especially including dental care, and local social support structures.
Developing practice guidelines to integrate physical activity promotion as part of routine cancer care: A knowledge-to-action protocol
Authors: Doré Isabelle , Plante Audrey , Bedrossian Nathalie , Montminy Sarah , St-Onge Kadia , St-Cyr Jany , Pomey Marie-Pascale , Charpentier Danielle , Pettigrew Lise , Brisson Isabelle , Saad Fred , Tournoux François , Raynault Marie-France , Mes-Masson Anne-Marie , Gauvin Lise 
Published: August 2022

Background
Cancer is a leading cause of disease burden worldwide and the first cause of mortality in Canada with 30.2% of deaths attributable to cancer. Given aging of the population and the improvement of prevention and treatment protocols, the number of cancer survivors is steadily increasing. These individuals have unique physical and mental health needs some of which can be addressed by integrating physical activity promotion into ongoing and long-term care. Despite the benefits of being active, delivery of PA programs for cancer patients in both clinical and community settings remains challenging. This knowledge-to-action protocol–called Kiné-Onco–aims to develop a practice guideline for the delivery, implementation, and scaling-up of cancer-specific physical activity promotion programs and services in clinical and community settings located in Québec, Canada.

Method
The Kiné-Onco project involves knowledge synthesis of scientific and grey literature to establish the benefits and added value of physical activity for cancer patients and survivors, describes current practices in delivering physical activity programs, analyses quantitative data from electronic health records (EHR) of patients participating in a novel hospital-based physical activity program, collects and analyses qualitative data from patients and healthcare providers interviews about lived experience, facilitators, and barriers to physical activity promotion, outlines deliberative workshops among multidisciplinary team members to develop implementation guidelines for physical activity promotion, and summarizes a variety of knowledge transfer and exchange activities to disseminate the practice guidelines.

Discussion
This paper describes the protocol for a knowledge-to-action project aimed at producing and sharing actionable evidence. Our aim is that physical activity promotion programs and services be scaled up in such a way as to successfully integrate physical activity promotion throughout cancer treatment and survivorship in order to improve the physical and mental health of the growing population of individuals having received a cancer diagnosis.
Prototype of a Solar Collector with the Recirculation of Nanofluids for a Convective Dryer
Authors: Garcia-Marquez Denis Del Sagrario , Andrade-Gonzalez Isaac , Chavez-Rodriguez Arturo-Moises , Montero-Cortes Mayra I , Farias-Cervantes Vania Sbeyde 
Published: August 2022

Solar collectors are thermal devices that can trap solar energy and convert it to heat. This heat can be used for different industrial applications, for example, the drying of food is one of the most useful applications of solar collectors. This work aims to design and build a solar collector using nanofluids for the convective drying of food. The dimensions of the solar collector were 1 m2 by 20 cm with an angle of inclination of 45°. The collector was composed of 9-mm thick tempered glass and a heat exchanger in which the nanofluids circulate. Nanofluids were designed based on canola oil and nanopowders (>50 nm) of Al2O3, CuO, and a 1:1 (w/w) mixture of both. Thermal profiles were determined using differential scanning calorimetry (DSC). The solar collector temperatures were recorded using an Agricos® unit. The maximum temperatures of the air leaving the collector were 39.1°C, 44°C, 54°C, and 47.1°C for canola oil, and the nanofluids composed of Al2O3, CuO, and the 1:1 mixture, respectively, with a maximum efficiency of 65.09%. An increase in the outlet air temperature was observed using the nanofluids compared to canola oil alone
p-adic polylogarithms and p-adic Hecke L-functions for totally real fields
Authors: Bannai Kenichi , Hagihara Kei , Yamada Kazuki , Yamamoto Shuji 
Published: August 2022

Abstract
The purpose of this article is to newly define the p-adic polylogarithm
as an equivariant class in the cohomology of a certain infinite disjoint union of algebraic tori
associated to a totally real field.
We will then express the special values of p-adic L-functions interpolating
nonpositive values of Hecke L-functions of the totally real field in terms of
special values of these p-adic polylogarithms.
Cervical strain elastography: pattern analysis and cervical sliding sign in preterm and control pregnancies
Authors: Debring Bianca , Möllers Mareike , Köster Helen A. , Kwiecien Robert , Braun Janina , Oelmeier Kathrin , Klockenbusch Walter , Schmitz Ralf 
Published: August 2022

Abstract

Objectives
The aim of this study was to assess the value of cervical strain elastography and Cervical Sliding Sign (CSS) for predicting spontaneous preterm birth (sPTB).

Methods
In our case-control study we performed an elastographic assessment of the cervix in 82 cases of preterm birth (preterm group) and 451 control pregnancies (control group) between the 20th and 37th week of gestation. We divided the anterior cervical lip first into two (“Intern2”, “Extern2”) and into three sectors (“Intern3”, “Middle3”, “Extern3”). The tissue deformation pattern after local compression with an ultrasound probe was recorded. We distinguished between an irregularly distributed (“Spotting”) and homogeneous pattern presentation. Additionally, the presence of a sliding of the anterior against the posterior cervical lip (positive CSS) during compression was evaluated. A logistic regression analysis and the Akaike Information Criterion (AIC) were used to estimate the probability of sPTB and to select a prediction model.

Results
Spotting and positive CSS occurred more frequently in the preterm group compared to control group (97.8 vs. 2.2%, p<0.001; 26.8 vs. 4.2%, p<0.001; respectively). The model with the parameters week of gestation at ultrasound examination, Intern3, Middle3 and CSS was calculated as the highest quality model for predicting sPTB. The AUC (Area Under the Curve) was higher for this parameter combination compared to cervical length (CL) (0.926 vs. 0.729).

Conclusions
Cervical strain elastography pattern analysis may be useful for the prediction of sPTB, as the combination of Spotting analysis and CSS is superior to CL measurement alone.
Transhumanism and Theological Anthropology: A Theological Examination of Transhumanism
Authors: Jung Daekyung 
Published: August 2022

Summary
Humans are now entering a post-human era. Through technological advancements and their applications for humans themselves, humans as homo sapiens might change into a different species. Depending on individual decisions about whether to embrace certain technologies, the co-existence of humans and post-humans is also possible. Christians and theologians must ponder this trajectory for the technology will affect all domains, including religions, in society at large. In this regard, this article introduces and examines transhumanism. Transhumanism is a movement based on the convergence of ideology and scientific technology which aims to liberate humans from their biological constraints (i. e., disease, aging, and death), thereby bringing about human well-being. This article argues that the transhumanist ideology should be critically examined while its technology can be embraced and even supported from a theological perspective because this ideology determines the direction of technological advancement and application. Regarding ideological problems, I highlight transhumanists’ disembodiment propensity, optimistic belief in the progress of human civilization, and individualism. These features are embedded in and originate from transhumanism’s succession of classical humanism and the Enlightenment. If these features are not rectified, transhumanism and its technology might repeat disastrous incidents in human history such as eugenics and exacerbate social inequality. As a theologian, I critically examine the ideological features of transhumanism, proposing an alternative understanding with regard to human beings and existence. This effort helps to remedy potential problems of transhumanism in the future, relieve anxiety relating to these problems, and prepare a dialogue between transhumanism and Christian theology. This dialogue will eventually contribute to the robust development of transhumanism and the opening of a new era of the post-human.
Is it the plants we know that we use? Unraveling the determining factors of ethnobotanical knowledge in a rural community in Central Mexico
Authors: Beltrán Leonardo , Gutierrez Jesús , Flores Gabriel , Saynes Alfredo , Maldonado Belinda , Blancas José , Ortiz Amanda 
Published: August 2022

The knowledge and use of plant resources are constantly evolving. In this work, the socio-cultural and economic factors that influence the ethnobotanical knowledge of a mestizo community in Mexico were analyzed, and the correspondence of two cultural indices (use value vs. practical value) was determined to identify the magnitude of the significance and utility of each of the ethnofloristic resources. The study was carried out through semi-structured interviews with 44 local informants. Free lists were applied, and the indexes of use value and practical value were used to document the most culturally important plants.
With an analysis of covariance (ANCOVA), the differences in botanical knowledge between genera and the effect of socioeconomic covariates on it were evaluated. 223 species were recorded in 54 botanical families and 86 genera, of which 48% were herbs and just over 60% of the total were recorded in homegardens. The Asteraceae family had the highest number of useful species followed by Fabaceae and Rosaceae. Of a total of 10 categories of use, medicinal, food and ornamental plants were the most representative. A weak correspondence was found between the cultural indices at the species level, but there was consistence at the level of use categories. The ANCOVA showed that there is no statistically significant difference between the genders and none of the covariates have a significant influence (p>0.05) on ethnobotanical knowledge. However, there was a consensus between men and women on the importance they give to medicinal and food plants.
Arterial stiffness and central aortic blood pressure in patients with hypertension and abdominal aortic aneurysm
Authors: Gurevich A. P. , Emelyanov I. V. , Boyarinova M. A. , Moguchaya E. V. , Rotar O. P. , Kudaev Y. A. , Chernyavskiy M. A. , Konradi A. O. 
Published: August 2022

Objective. To assess the arterial stiffness, peripheral and central aortic blood pressure (PBP and CBP), and to determinate their relationships with indicators of structural changes of the affected aorta in patients with hypertension (HTN) and abdominal aortic aneurysms (AAA).Design and methods. We examined 75 patients with HTN and AAA and 75 controls with HTN without AAA. Groups matched by age and gender. A PBP was measured by OMRON (Japan). Noninvasive measurements of CBP, augmentation index (AIx), augmentation pressure (AP), carotid-femoral pulse wave velocity (cfPWV) were assessed by SphygmoCor (AtCorMedical, Australia).Results. There was no difference in cfPWV between patients with AAA and control group (10,3 (2,2) vs 9,7 (2,1) m/s; р = 0,102). Age, systolic PBP, and aortic diameter were independent predictors of cfPVV in patients with AAA (β = 0,271, р = 0,029; β = 0,272, р = 0,030 и β = –0,361, р = 0,004, respectively). Patients with large aortic diameter of AAA (> 60 mm) had decreased cfPWV compared with control group (8,8 (1,5) vs 9,7 (2,1) m/s; р < 0,05), patients with AAA diameter less than 60 mm, on the contrary, had increased cfPVV compared with the controls (11,8 (1,7) vs 9,7 (2,1) m/s; р < 0,001). Patients with AAA and patients of control group did not differ in systolic and pulse PBP (138,6 (16,4) vs 138,1 (13,6) mm Hg; р = 0,831 and 58,6 (11,8) vs 59,6 (10,2) mm Hg; р = 0,569, respectively). AIx and AP were higher in patients with AAA versus patients without AAA (27,6 (8,2) vs 21,3 (7,9)%; р < 0,001 and 17,3 (6,8) vs 13,9 (5,4) mm Hg; р = 0,001, respectively). Systolic and pulse CBP were higher in patients with AAA than in patients of control group (130,0 (16,4) vs 124,9 (13,9) mm Hg; р = 0,046 and 49,5 (11,7) vs 45,7 (9,9) mm Hg; р = 0,031, respectively).Conclusions. In patients with AAA cfPWV decreased with the expansion of the maximum aortic diameter. CfPWV is not suitable for accurate arterial stiffness assessment in patients with HTN and AAA due to the apparent confounding effect of aneurysm on the biomechanical properties of the aorta. Local assessment of the elastic properties of the aorta such as computed tomography angiography and magnetic resonance imaging is required for arterial stiffness evaluation in patients with AAA. Parameters of the reflected pulse wave such as AP and AIx are increased in patients with AAA. This might contribute to the increase in central aortic BP and target organ damage in patients with HTN combined with AAA.
Late Paleozoic Shortening in South-Central Nevada and Regional Correlations of Major Pre-Sevier Structures
Authors: Russo Angela G. , Taylor Wanda J. , Cashman Patricia H. 
Published: August 2022

Recent tectonic reinterpretations of the Late Paleozoic Southwest Laurentian margins recognize widespread Late Paleozoic deformation as a critical component in the boundary region development. Overprinted late Paleozoic structures record repeated shortening events in both northern and southern Nevada, but spatial and temporal data are currently lacking to resolve the evolution of this margin. The Timpahute Range, south-central Nevada, bridges part of the spatial gap between previous detailed studies of Late Paleozoic deformation. The purpose here is to (1) evaluate structures in the area that do not appear to fit with recognized Sevier hinterland structures (the Central Nevada thrust belt [CNTB]) and (2) consider whether these contractional structures may be Late Paleozoic and possibly link, or not, structures to the north and south.
New mapping in the Timpahute Range documents four geometrically or kinematically distinct sets of structures: Tempiute Ridge folds, Schofield Pass fault zone (SPFZ), structures of the CNTB, and Cenozoic extensional faults. The first three are interpreted to represent separate shortening events based on cross-cutting relations and differences in orientations of the Tempiute Ridge folds and SPFZ (north [N]), and structures of the CNTB (northwest [NW]). The Tempiute Ridge folds represent the oldest event, D1. These folds are large, trend N and verge east (E). The SPFZ is west (W)-vergent, cuts across the limb of a D1 fold and represents D2. The SPFZ is interpreted to be older than the CNTB structures, D3, based on positions of fault cut offs, and differences in footwall and hangingwall facies. All of the shortening events predate the newly dated 102.9 ± 3.2 Ma Lincoln stock and its contact metamorphic aureole.
New and previous correlations suggest that a belt of Permian deformation extends from southeast (SE) California northward at least to the Timpahute Range. The Tempiute Ridge folds and SPFZ have the same distinctive geometries, styles, and kinematics as structures in the Nevada National Security Site. The mountain-size, E-vergent Tempiute Ridge folds and the W-vergent SPFZ correlate to structures associated with the Belted Range thrust and the W-vergent CP thrust, respectively. The Belted Range thrust previously has been correlated southward into the Death Valley region. Thus, convergence created large-amplitude folds and thrusts for ~200 km along strike. Structures of this age are exposed in northern Nevada but are smaller. These new relations fill a data gap and suggest differences in the size and structural style of Permian structures along strike and corresponding variations in the plate boundary configuration.
Gastrointestinal bleeding during the COVID-19 pandemic: More severe and less clear
Authors: Kerbage Anthony , Barada Kassem , Alrazim Ayman , Tamim Hani , Makki Maha , Shaib Yasser H. 
Published: August 2022

Abstract
Background
The COVID-19 pandemic has led patients to avoid medical care, and hospitals to limit high-risk procedures.
Methods
We conducted a cohort study to assess the impact of the COVID-19 pandemic on the presentation and outcomes of gastrointestinal bleeding (GIB).
Results
Patients admitted during the pandemic were more likely to present with severe hemorrhage and to have a drop of hemoglobin ≥ 2g/dL. The origin of GIB was also more likely to remain unknown. Admission during the pandemic was an independent predictor of severe hemorrhage (HR = 2.08, [1.07–4.05]).
Conclusion
During the COVID-19 pandemic, patients with GIB were more likely to present with more severe hemorrhage.