bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular characterization of low-grade serous ovarian carcinoma identifies genomic aberrations according to hormone receptor expression
Authors: Cheasley Dane , Fernandez Marta Llaurado , Köbel Martin , Kim Hannah , Dawson Amy , Hoenisch Joshua , Bittner Madison , Chiu Derek S. , Talhouk Aline , Gilks C. Blake , Jayawardana Madawa W. , Pishas Kathleen I. , Mes-Masson Anne-Marie , Provencher Diane , Nigam Abhimanyu , Hacker Neville F. , Gorringe Kylie L. , Campbell Ian G. , Carey Mark S. 
Published: June 2022

AbstractHormone receptor expression is a characteristic of low-grade serous ovarian carcinoma (LGSOC). Studies investigating estrogen receptor (ER) and progesterone receptor (PR) expression levels suggest its prognostic and predictive significance, although their associations with key molecular aberrations are not well understood. As such, we sought to describe the specific genomic profiles associated with different ER/PR expression patterns and survival outcomes in a cohort of patients with advanced disease. The study comprised fifty-five advanced-staged (III/IV) LGSOCs from the Canadian Ovarian Experimental Unified Resource (COEUR) for which targeted mutation sequencing, copy-number aberration, clinical and follow-up data were available. ER, PR, and p16 expression were assessed by immunohistochemistry. Tumors were divided into low and high ER/PR expression groups based on Allred scoring. Copy number analysis revealed that PR-low tumors (Allred score <2) had a higher fraction of the genome altered by copy number changes compared to PR-high tumors (p = 0.001), with cancer genes affected within specific loci linked to altered peptidyl-tyrosine kinase, MAP-kinase, and PI3-kinase signaling. Cox regression analysis showed that ER-high (p = 0.02), PR-high (p = 0.03), stage III disease (p = 0.02), low residual disease burden (p = 0.01) and normal p16 expression (p<0.001) were all significantly associated with improved overall survival. This study provides evidence that genomic aberrations are linked to ER/PR expression in primary LGSOC.
The non-steroidal mineralocorticoid receptor antagonist finerenone is a novel therapeutic option for patients with Type 2 diabetes and chronic kidney disease
Authors: Barrera-Chimal Jonatan , Gerarduzzi Casimiro , Rossignol Patrick , Jaisser Frédéric 
Published: June 2022

Abstract
Despite strong preclinical data supporting the use of mineralocorticoid receptor antagonists (MRAs) to provide cardiorenal protection in rodent models of diabetes, the clinical evidence of their utility in treating chronic kidney disease (CKD) has been limited. Two major clinical trials (FIDELIO-DKD and FIGARO-DKD) including more than 13,000 patients with albuminuric CKD and Type 2 diabetes randomized to placebo or finerenone (MRA) have recently provided exciting results showing a significant risk reduction for kidney and cardiovascular outcomes. In this review, we will summarize the major findings of these trials, together with post-hoc and pooled analyses that have allowed evaluation of the efficacy and safety of finerenone across the spectrum of CKD, revealing significant protective effects of finerenone against kidney failure, new-onset atrial fibrillation or flutter, new-onset heart failure, cardiovascular death, and first and total heart-failure hospitalizations. Moreover, we will discuss the current evidence that supports the combined use of MRAs with sodium-glucose co-transporter-2 inhibitors, either by providing an additive cardiorenal benefit or by decreasing the risk of hyperkalemia. Although the mechanisms of protection by finerenone have only been partially explored in patients, rodent studies have shed light on its anti-inflammatory and anti-fibrotic effects in models of kidney disease, which is one of the main drivers for testing the efficacy of finerenone in non-diabetic CKD patients in the ongoing FIND-CKD trial.
Few‐shot multiscene fault diagnosis of rolling bearing under compound variable working conditions
Authors: Wang Sihan , Wang Dazhi , Kong Deshan , Li Wenhui , Wang Jiaxing , Wang Huanjie 
Published: June 2022

AbstractAs one of the most widely used rotating machinery components, whether the bearing can operate stably is related to the reliability of the equipment and the safety of the staff. Therefore, efficient and accurate intelligent fault diagnosis (IFD) technology is necessary for modern industrial equipment. Bearing fault diagnosis based on deep learning methods has made great progress in recent years. However, most methods rely heavily on massive data and the domain shift phenomenon caused by the high‐level compound variable working conditions would greatly affect the performance of the model. To solve the data sparsity and domain shift problem simultaneously, an effective feature disentanglement and restitution (FDR) few‐shot method is proposed for IFD under multiple scenes. First, the vibration signals are preprocessed and input into the metric‐based neural network. The model is trained based on the meta‐learning method to extract task‐level general features to alleviate the data sparsity problem. Then, the FDR method extracted task‐related features from the information discarded by the convolution kernel at different scales and fused them with the output features of the embedding module to reconstruct task‐specific features and alleviate the phenomenon of domain shift. Finally, the relational module automatically extracts the nonlinear relations between features and classifies them. A number of high‐level compound variable working condition tasks were constructed on two experimental platforms, and the fault diagnosis tests with small samples and multiple scenes were carried out. The results show that our proposed method has superior accuracy and transferability under compound variable working conditions.
An improved second‐order kinetic model for degradation analysis of transformer paper insulation under non‐uniform thermal field
Authors: Liu Jiefeng , Jiang Kuo , Wang Qingyin , Zhang Heng , Zhang Enze , Fan Xianhao , Zhang Yiyi 
Published: June 2022

AbstractThe ageing kinetic model is regarded as an effective tool to describe the degradation of transformer paper insulation. However, the temperature of the transformer winding is unevenly distributed, and the existing ageing kinetic models only depend on experimental data of accelerated thermal ageing at a constant temperature. Given this issue, this work proposes an improved second‐order kinetic model accounting for the non‐uniform thermal field. First, oil‐paper insulation samples with different ageing stages are prepared under the non‐uniform thermal field. Then, the sample's experimental data of moisture dispersion and distribution of degree of polymerisation are collected. On this basis, the improved second‐order kinetic model is derived to simulate insulating paper's ageing process subjected to an axial temperature gradient. Further, the relationship of the parameters in the improved second‐order kinetic model with the temperature and moisture content at different winding heights is obtained. Finally, the proposed model is validated, and the results show that the proposed model is more scientific than the traditional models to describe the degradation of paper insulation. In that respect, this work illustrates an improved second‐order kinetic model to provide a reference for the ageing assessment/life prediction of transformer paper insulation under the non‐uniform thermal field.
Liebe Kolleginnen und Kollegen,
Authors: Proff Peter , Deschner James 
Published: June 2022

Liebe Kolleginnen und Kollegendie Kieferorthopädie ist ein zentraler Bestandteil der zahnärztlichen
Versorgung und kann einen wesentlichen Beitrag zur Rehabilitation im parodontal
kompromittierten Gebiss leisten. Aufgrund der demografischen Entwicklung in
Deutschland ist auch in Zukunft von einem zunehmenden Behandlungsbedarf
auszugehen.
Klassifikation parodontaler und periimplantärer Erkrankungen
und Zustände
Authors: Deschner James , Hagner Martin 
Published: June 2022

ZusammenfassungAuf einer gemeinsamen Konsensuskonferenz der American Academy of Periodontology
(AAP) und der European Federation of Periodontology (EFP) im November 2017 wurde
ein neues Schema zur Klassifikation parodontaler und periimplantärer
Erkrankungen und Zustände beschlossen. Entsprechend diesem neuen
Klassifikationsschema gibt es nun nur noch drei Formen der Parodontitis: 1)
Parodontitis, 2) nekrotisierende parodontale Erkrankungen und 3) Parodontitis
als Manifestation einer systemischen Erkrankung. Jeder Parodontitis kann ein
Stadium, ein Grad sowie die Ausdehnung bzw. das Verteilungsmuster zugeordnet
werden. Das Stadium der Parodontitis ergibt sich aus dem Schweregrad der
Erkrankung und der Komplexität des Therapiemanagements. Der Grad der
Parodontitis liefert vor allem Informationen über die Progressionsrate
der Erkrankung. Das neue Klassifikationsschema ist komplex, stellt aber im
Vergleich mit der alten Klassifikation parodontaler Erkrankungen einen
deutlichen Fortschritt dar. Das neue Klassifikationsschema definiert erstmals
gingivale und parodontale Gesundheit, berücksichtigt die
Komplexität der Behandlung und würdigt zudem den
möglichen Einfluss von Risikofaktoren auf den Krankheitsverlauf.
Die kieferorthopädische Aufrichtung gekippter
Molaren
Authors: Sabbagh Hisham , Sabbagh Aladin 
Published: June 2022

ZusammenfassungDie kieferorthopädische Aufrichtung gekippter Molaren stellt eine
häufige Behandlungsaufgabe dar. Dabei stehen neben funktionellen und
präventiven Überlegungen vor allem parodontologische und
prothetische Aspekte bei der Therapieplanung im Vordergrund. In der Literatur
sind eine Vielzahl von Mechaniken und Methoden zur kieferorthopädischen
Molarenaufrichtung beschrieben. Dabei erweitert der Einsatz von Mini-Implantaten
heute das Spektrum der Verankerungsmöglichkeiten. Für die
Auswahl einer geeigneten Mechanik sind die individuelle Ausgangsituation, das
für die Therapieziele benötigte Kräftesystem und die
Verankerung zu berücksichtigen. Im vorliegenden Artikel soll neben
differentialtherapeutischen Überlegungen zu ausgewählten
Mechaniken die Klinik der Molarenaufrichtung anhand von Fallbeispielen
dargestellt werden.
A Rare Case of Life-Threatening Extensive Mucocutaneous Adverse Reaction Induced by Docetaxel in a Breast Cancer Patient: Toxic Epidermal Necrolysis, a Case Report with Review of Literature
Authors: Shrivastava Shiv Prasad , Elhence Aditya , Jinwala Prutha , Bansal Shashank , Chitalkar Prakash , Bhatnagar Shweta , Patidar Rajesh , Asati Vikas 
Published: June 2022

AbstractFever and extensive necrosis with 30% or more epidermal involvement along with mucous membrane is known as toxic epidermal necrolysis (TEN). It is a life-threatening mucocutaneous disease and is usually drug induced. We report a rare case of docetaxel-induced TEN. A patient with metastatic breast carcinoma received single agent docetaxel and developed severe skin and mucous membrane reaction involving more than 30% of the skin, and managed conservatively in intensive care unit but she succumbed to her illness. Although common toxicities reported with docetaxel include alopecia, nail damage, myelosuppression, and erythema multiforme major, TEN after docetaxel is very rare and can be a life-threatening complication as in our case.
Planar 99mTc-PSMA Imaging of Prostate Cancer in a Low-Resource Setting: A Series Report
Authors: Orunmuyi A.T. , Oladeji A.A. , Azodoh E.U. , Omisanjo O.A. , Olapade-Olaopa E.O. 
Published: June 2022

Abstract
Objective Technetium-99m labeled prostate-specific membrane antigen (PSMA) single-photon emission computed tomography/computed tomography (SPECT/CT) is a suitable alternative to prostate-specific membrane antigen-positron emission tomography (PSMA-PET) imaging. However, the availability of SPECT/CT in many developing countries is limited.
Materials and Methods To evaluate the utility of planar 99mTc-PSMA in the absence of SPECT/CT, we compared planar 99mTc-PSMA and routine bone scan imaging in low-, intermediate-, and high-risk prostate cancer in five patients with histologically confirmed prostate cancer who had both scans within a period of less than 4 days. The mean age of patients was 66.8 ± 5.24, and the median prostate-specific antigen level was 175 ng/mL (range: 0–778 ng/mL).
Results Planar 99mTc-PSMA scan provided no additional benefit over bone scans in the low-risk prostate cancer cases. In the cases with intermediate-risk prostate cancers, planar 99mTc-PSMA indicated complete and partial response to treatment in oligometastatic and widespread metastatic disease, respectively. In one patient with high-risk prostate cancer, planar 99mTc-PSMA detected additional skeletal lesions that were not seen on bone scan.
Conclusion In the absence of SPECT/CT, planar 99mTc-PSMA was useful for confirming extent of disease in treated intermediate- and high-risk prostate cancer. It showed little value in low-risk prostate cancer, especially when bone scan is normal. It was particularly useful for treatment response assessment in oligometastatic disease, and its utility should be further explored.
High-order (N = 4–6) multiphoton absorption and mid-infrared Kerr nonlinearity in GaP, ZnSe, GaSe, and ZGP crystals
Authors: Kawamori Taiki , Schunemann Peter G. , Gruzdev Vitaly , Vodopyanov Konstantin L. 
Published: June 2022

We report a study of high-order multiphoton absorption, nonlinear refraction, and their anisotropy in four notable mid-infrared χ(2) crystals: GaP, ZnSe, GaSe, and ZGP using femtosecond pulses at 2.35 μm with peak intensity in excess of 200 GW/cm2. We found that the nonlinear absorption obeys a perturbation model with multiphoton absorption (MPA) orders from N = 4–6, in agreement with the bandgaps of the crystals. A study of the role of free carrier absorption, performed by changing the pulse duration from 30 to 70 fs while maintaining a constant peak intensity, showed that, at our intensity levels, free carriers generated during the MPA process absorb much more strongly than would be expected from their known linear absorption cross section. Possible mechanisms for this anomalous behavior are high-field effects, such as intravalley scattering in the conduction band and absorption to higher lying bands. Nonlinear refractive indices were measured using (i) closed aperture Z-scan and (ii) spectral broadening due to self-phase modulation, both methods agreeing with each other.
Bacteriophages evolve enhanced persistence to a mucosal surface
Authors: Chin Wai Hoe , Kett Ciaren , Cooper Oren , Müseler Deike , Zhang Yaqi , Bamert Rebecca S. , Patwa Ruzeen , Woods Laura C. , Devendran Citsabehsan , Korneev Denis , Tiralongo Joe , Lithgow Trevor , McDonald Michael J. , Neild Adrian , Barr Jeremy J. 
Published: June 2022

The majority of viruses within the gut are obligate bacterial viruses known as bacteriophages (phages). Their bacteriotropism underscores the study of phage ecology in the gut, where they modulate and coevolve with gut bacterial communities. Traditionally, these ecological and evolutionary questions were investigated empirically via in vitro experimental evolution and, more recently, in vivo models were adopted to account for physiologically relevant conditions of the gut. Here, we probed beyond conventional phage–bacteria coevolution to investigate potential tripartite evolutionary interactions between phages, their bacterial hosts, and the mammalian gut mucosa. To capture the role of the mammalian gut, we recapitulated a life-like gut mucosal layer using in vitro lab-on-a-chip devices (to wit, the gut-on-a-chip) and showed that the mucosal environment supports stable phage–bacteria coexistence. Next, we experimentally coevolved lytic phage populations within the gut-on-a-chip devices alongside their bacterial hosts. We found that while phages adapt to the mucosal environment via de novo mutations, genetic recombination was the key evolutionary force in driving mutational fitness. A single mutation in the phage capsid protein Hoc—known to facilitate phage adherence to mucus—caused altered phage binding to fucosylated mucin glycans. We demonstrated that the altered glycan-binding phenotype provided the evolved mutant phage a competitive fitness advantage over its ancestral wild-type phage in the gut-on-a-chip mucosal environment. Collectively, our findings revealed that phages—in addition to their evolutionary relationship with bacteria—are able to evolve in response to a mammalian-derived mucosal environment.
Medical management of acute radiation syndrome
Authors: Dainiak Nicholas , Albanese Joseph 
Published: June 2022

Abstract
Acute radiation syndrome (ARS) is a clinical syndrome involving four organ systems, resulting in the hematopoietic syndrome (HS), gastrointestinal subsyndrome (GIS), neurovascular subsyndrome (NVS) and cutaneous subsyndrome (CS). Since few healthcare providers have seen an ARS case, evidence-based recommendations are needed to guide medical management in a mass casualty scenario. The authors reviewed recommendations from evidence-based and narrative reviews by expert consultants to the World Health Organisation (WHO), a subsequent review of published HS cases, and infectious disease guidelines for management of febrile neutropenia. The WHO Consultancy applied a rigorous grading system to evaluate treatment strategies described in published ARS cases as of 2009, strategies to manage HS in unirradiated persons, results of ARS studies in animal models of ARS, and recommendations of prior expert panels. Major findings for HS were (a) no randomised controlled studies have been performed, (b) data are restricted by the lack of comparator groups, and (c) reports of countermeasures for management of injury to non-hematopoietic organs are often incomplete. Strength of recommendations ranged from strong to weak. Countermeasures of potential benefit include cytokines and for a subgroup of HS patients, hematopoietic stem cell transplantation. These recommendations did not change in a subsequent analysis of HS cases. Recommendations also included fluoroquinolones, bowel decontamination, serotonin receptor antagonists, loperamide and enteral nutrition for GIS; supportive care for NVS; and topical steroids, antihistamines and antibiotics, and surgical excision/grafting for CS. Also reviewed are critical care management guidelines, the role of mesenchymal stem cells for CS, the potential of a platelet-stimulating cytokine for HS, and the author’s approach to clinical management of microbial infections associated with ARS based on published guidelines of infectious disease experts. Today’s management of HS is supported by evidence-based guidelines. Management of non-HS subsyndromes is supported by a narrative review of the literature and recommendations of infectious disease societies.
Embedded sensing and actuating in CFRP composite structures—concept and technology demonstration for tailored embeddable sensor-actuator layers (TEmSAL)
Authors: Hornig Andreas , Frohberg Richard , Bätzel Tim , Gude Maik , Modler Niels 
Published: June 2022

Abstract
Carbon fibre reinforced plastic (CFRP) materials are of interest for the aerospace and aviation industry to master growing economic and ecological challenges. In contrast to conventional metallic materials, they offer both higher specific material properties, such as strengths, stiffnesses, and an increased energy absorption capacity in case of impact loading scenarios. Additionally, the possibility of integrating functional elements, such as actuators and sensors, predestine CFRP for the development of more lightweight structural components. In this study, a generic composite structure is instrumented with embedded piezo ceramic sensor elements. A technology for TEmSAL is presented and applied within an autoclave manufacturing process. Aspects of the designing process, manufacturing and instrumentation as well as experimental impact sensing and self-actuation results are presented and discussed.
All-angle broadband ENZ metamaterials
Authors: Sun Lei , Lin Yashan , Yu Kin Wah , Wang Guo Ping 
Published: June 2022

Abstract
A novel type of metamaterial is presented to produce broadband near-zero effective permittivity to a defined polarized probing electromagnetic wave with varying angles of incidence. The metamaterial has a uniaxial unit cell structure made up of symmetric periodic multilayer superlattices with a rotational symmetry about the polarization of the probing electromagnetic wave. The unit cell is rigorously constructed based on the Bergman–Milton spectral representation of the effective permittivity, and its electrodynamic properties are theoretically verified by the eigenmode analysis, the band structure, the dispersion relation, and the isofrequency contours. The eigenmode analysis illustrates that the unit cell can be effectively regarded as a photonic crystal or a waveguide according to the incidence direction of the probing electromagnetic wave, and either of them is of the dynamic microstructure related to the frequency, which results in a broadband response. Meanwhile, the band structure, the dispersion relation, and the isofrequency contours show that the unit cell has the near-zero effective permittivity at all angles of incidence of the specified polarized probing electromagnetic wave. Finally, the reflection/transmission/absorption spectra to the prescribed polarization probing electromagnetic wave vividly reveal the all-angle broadband near-zero effective permittivity property of the metamaterial.
Feasibility studies of strangeness production in heavy-ion interactions at the BM@N experiment using Monte Carlo simulations
Authors: Baranov D , Kapishin M , Schmidt H R , Senger P , Vasendina V , Zinchenko A , Zinchenko D 
Published: June 2022

Abstract
In 2022, the Baryonic Matter at Nuclotron (BM@N) experimental setup at JINR (Dubna) will be ready in its full configuration to investigate heavy-ion interactions. At the same time, the accelerator complex of the Booster and Nuclotron is being prepared to accelerate and deliver extracted heavy-ion beams to the BM@N fixed target zone. One of the physics objectives, which BM@N will be able to pursue, is measurement of the (multi)strange hyperon excitation functions, i.e. hyperon yields at different energies. These measurements can help to determine the equation of state of the high-density baryonic matter. In this paper, the results of the Monte Carlo simulation of the BM@N detector performance for studying strangeness production in heavy-ion interactions in future runs are presented.
Experimental Study of Micrometeoroids Impacts on an X-Ray Telescope Model using Micro-pore Optics and CMOS Detector with Micron-sized Particles
Authors: Yang Xue , Zhang Chen , Wang Wenxin , Li Hongwei , Zhang Shuang-Nan , Yuan Weimin , Ling Zhixing , Jin Ge , Zhang Zhen , Li Longhui 
Published: June 2022

Abstract
This laboratory study aimed to assess the potential damage caused by the impact of micrometeoroids or space debris on a novel X-ray focusing telescope composed of Micro-pore Optics (MPO) plates and Complementary Metal Oxide Semiconductor (CMOS) sensors. An impact experiment was conducted on a simplified model of an X-ray telescope composed of two MPO plates and one CMOS sensor. The diameters of the projectiles we used are 1 ∼ 50 μm. Scanning electron microscopy and energy-dispersive X-ray spectroscopy (EDS) are methods for investigating the morphology of the impact craters and analyzing the composition of residues. We described the impact crater morphology on both MPO plates and CMOS chips. Results of impact craters size and number show that one 1 μm particle produces a damaged area of 18 μm2 in aluminum (Al) film of the MPO plate on average (at a median speed of 2 km s−1), resulting in 10 light leak spots on the CMOS chip. Meanwhile, one particle with a diameter of 50 μm may damage 3 micropores (about 7 × 10−3 mm2) on the MPO plate at a median speed of 6 km s−1. About 1.5 particles could cause one bad pixel on the CMOS chip behind the MPO plates. Nevertheless, no failure of the CMOS sensor or severe damage to the MPO device was observed after the impact.