bluuebunny/crossref_metadata_2025_split huggingface dataset:
Layered Cathode Materials: Precursors, Synthesis, Microstructure, Electrochemical Properties, and Battery Performance
Authors: Huang Bin , Cheng Lei , Li Xinze , Zhao Zaowen , Yang Jianwen , Li Yanwei , Pang Youyong , Cao Guozhong 
Published: February 2022

AbstractThe exploitation of clean energy promotes the exploration of next‐generation lithium‐ion batteries (LIBs) with high energy‐density, long life, high safety, and low cost. Ni‐rich layered cathode materials are one of the most promising candidates for next‐generation LIBs. Numerous studies focusing on the synthesis and modifications of the layered cathode materials are published every year. Many physical features of precursors, such as density, morphology, size distribution, and microstructure of primary particles pass to the resulting cathode materials, thus significantly affecting their electrochemical properties and battery performance. This review focuses on the recent advances in the controlled synthesis of hydroxide precursors and the growth of particles. The essential parameters in controlled coprecipitation are discussed in detail. Some innovative technologies for precursor modifications and for the synthesis of novel precursors are highlighted. In addition, future perspectives of the development of hydroxide precursors are presented.
GSH‐Responsive Metal–Organic Framework for Intratumoral Release of NO and IDO Inhibitor to Enhance Antitumor Immunotherapy
Authors: Du Lihua , He Haozhe , Xiao Zecong , Xiao Hong , An Yongcheng , Zhong Huihai , Lin Minzhao , Meng Xiaochun , Han Shisong , Shuai Xintao 
Published: February 2022

AbstractImmunotherapy brings great benefits for tumor therapy in clinical treatments but encounters the severe challenge of low response rate mainly because of the immunosuppressive tumor microenvironment. Multifunctional nanoplatforms integrating effective drug delivery and medical imaging offer tremendous potential for cancer treatment, which may play a critical role in combinational immunotherapy to overcome the immunosuppressive microenvironment for efficient tumor therapy. Here, a nanodrug (BMS‐SNAP‐MOF) is prepared using glutathione (GSH)‐sensitive metal–organic framework (MOF) to encapsulate an immunosuppressive enzyme indoleamine 2,3‐dioxygenase (IDO) inhibitor BMS‐986205, and the nitric oxide (NO) donor s‐nitrosothiol groups. The high T1 relaxivity allows magnetic resonance imaging to monitor nanodrug distribution in vivo. After the nanodrug accumulation in tumor tissue via the EPR effect and subsequent internalization into tumor cells, the enriched GSH therein triggers cascade reactions with MOF, which disassembles the nanodrug to rapidly release the IDO‐inhibitory BMS‐986205 and produces abundant NO. Consequently, the IDO inhibitor and NO synergistically modulate the immunosuppressive tumor microenvironment with increase CD8+ T cells and reduce Treg cells to result in highly effective immunotherapy. In an animal study, treatment using this theranostic nanodrug achieves obvious regressions of both primary and distant 4T1 tumors, highlighting its application potential in advanced tumor immunotherapy.
Vascular Derived ECM Improves Therapeutic Index of BMP‐2 and Drives Vascularized Bone Regeneration
Authors: Chen Jiayu , Zhou Xingzhi , Sun Wenquan , Zhang Zengjie , Teng Wangsiyuan , Wang Fangqian , Sun Hangxiang , Zhang Wei , Wang Jianwei , Yu Xiaohua , Ye Zhaoming , Li Weixu 
Published: February 2022

AbstractVascularized osteogenesis is essential for successful bone regeneration, yet its realization during large size bone defect healing remains challenging due to the difficulty to couple multiple biological processes. Herein, harnessing the intrinsic angiogenic potential of vascular derived extracellular matrix (vECM) and its specific affinity to growth factors, a vECM/GelMA based hybrid hydrogel delivery system is constructed to achieve optimized bone morphogenetic protein‐2 (BMP‐2) therapeutic index and provide intrinsic angiogenic induction during bone healing. The incorporation of vECM not only effectively regulates BMP‐2 kinetics to match the bone healing timeframe, but also promotes angiogenesis both in vitro and in vivo. In vivo results also show that vECM‐mediated BMP‐2 release remarkably enhances vascularized bone formation for critical size bone defects. In particular, blood vessel ingrowth stained with CD31 marker in the defect area is substantially encouraged over the course of healing, suggesting incorporation of vECM served roles in both angiogenesis and osteogenesis. Thus, the authors’ study exemplifies that affinity of growth factor towards ECM may be a promising strategy to be leveraged to develop sophisticated delivery systems endowed with desirable properties for regenerative medicine applications.
Filament Engineering of Two‐Dimensional h‐BN for a Self‐Power Mechano‐Nociceptor System
Authors: Ding Guanglong , Chen Ruo‐Si , Xie Peng , Yang Baidong , Shang Gang , Liu Yang , Gao Lili , Mo Wen‐Ai , Zhou Kui , Han Su‐Ting , Zhou Ye 
Published: February 2022

AbstractThe switching variability caused by intrinsic stochasticity of the ionic/atomic motions during the conductive filaments (CFs) formation process largely limits the applications of diffusive memristors (DMs), including artificial neurons, neuromorphic computing and artificial sensory systems. In this study, a DM device with improved device uniformity based on well‐crystallized two‐dimensional (2D) h‐BN, which can restrict the CFs formation from three to two dimensions due to the high migration barrier of Ag+ between h‐BN interlayer, is developed. The BN‐DM has potential arrayable feature with high device yield of 88%, which can be applied for building a reservoir computing system for digital pattern recognition with high accuracy rate of 96%, and used as an artificial nociceptor to sense the external noxious stimuli and mimic the important biological nociceptor properties. By connecting the BN‐DM to a self‐made triboelectric nanogenerator (TENG), a self‐power mechano‐nociceptor system, which can successfully mimic the important nociceptor features of “threshold”, “relaxation” and “allodynia” is designed.
In Situ Electrospinning of Aggregation‐Induced Emission Nanofibrous Dressing for Wound Healing
Authors: Dong Ruihua , Li Ying , Chen Mian , Xiao Peihong , Wu Yifan , Zhou Kun , Zhao Zheng , Tang Ben Zhong 
Published: February 2022

AbstractRapid wound dressing and effective antibacterial therapy that meet the extreme requirements of emergency situations are urgently needed for treating skin wounds. Here, an in situ deposited and personalized nanofibrous dressing is reported which can be directly electrospun on skin wounds by a handheld electrospinning device and perfectly fits different wounds of various sizes. Moreover, an aggregation‐induced emission luminogen with photodynamic therapy effect is loaded in the nanofibrous dressings which endows the dressing's long‐term antibacterial activity during the wound healing process. The in situ electrospun nanofibers show excellent antimicrobial activity against Staphylococcus aureus (S. aureus) and methicillin‐resistant Staphylococcus aureus. In vivo studies demonstrate that these antibacterial nanofibrous dressings can effectively reduce inflammation and significantly accelerate wound healing. Such an in situ produced antibacterial dressing is promising as a total solution for treating emergencies, including patient‐specific clinical wounds and military injuries.
A novel watermarking scheme based on discrete wavelet transform‐singular value decomposition
Authors: Yasmeen Fauzia , Uddin Mohammad Shorif 
Published: February 2022

AbstractDue to the rapid advancement in information technology, individuals as well as organizations frequently transfer or share their digital content via cyberspace. The security and integrity of this digital content become a big concern, as any middleman can misuse or temper this content. Digital watermarking is a blessing to protect it from any unwanted tampering. Even though many researchers have implemented various watermarking approaches, but still ownership protection and reliability concerns are not fully mitigated. This paper proposes an improved novel hybrid watermarking scheme by combining discrete wavelet transform (DWT) with singular value decomposition (SVD) to minimize these concerns. At first, the host image is decomposed by multi‐level DWT and a two‐level SVD is applied to the fourth lower‐level coefficient (LL5) of the host image. Then the watermark is inserted into the specified sub‐band of the host image. The watermark is extracted in a reverse manner. The hybridization of DWT and SVD ensures that the watermarking technique performs better in terms of visual distortion and robustness. The outcomes of the experiment show that our proposed method is more robust, imperceptible, and secure than the existing DWT‐SVD based methods, even with a broad watermark scale.
Exploring graduate student roles and responsibilities in enhancing sense of belonging in residence life during COVID‐19
Authors: Hernández Erin , Kalstrom Benjamin , Murray Abigail , Nelson Zoe , Squire Dian 
Published: March 2022

AbstractBased on an autoethnographic study, this article aims to better understand how graduate student residence life staff made sense of their responsibilities and roles in enhancing student belonging within residence halls. The article also explores how the graduate students’ own sense of belonging was impacted as a result of COVID‐19 policy.
A simple and sensitive liquid chromatography–tandem mass spectrometry method for quantification of multi‐residual pesticides in blood
Authors: Kumar Dileshwar , Sinha Sukesh Narayan , Ungarala Ramakrishna , Mungamuri Sathish Kumar , Kasturi Vasudev 
Published: February 2022

AbstractPesticides are synthetic chemical compounds that are toxic and may cause toxicity when exposed in large quantities. The leading site of action of these compounds is the inhibition of acetylcholinesterase. Quantifying the pesticide levels in the human body can help understand and study pesticide exposure in humans. The study aimed to develop and validate a rapid and accurate liquid chromatography–tandem mass spectrometry method for the quantitative determination of pesticide concentration in human blood samples. The analytes were separated using an Agilent Stable Bond C18 column and a mobile phase containing 10 mM ammonium formate in water and acetonitrile. The limits of detection and quantitation from the developed method were 0.023–0.161 and 0.072–0.487 ng/mL, respectively, while the recoveries from the spiked blood samples were 78.01–104.36%. The intraday and interday accuracies and precision were 40–105% and 0.5–13 RSD% and 40–113% and 3–14 RSD%, respectively. Linear regression was obtained at a value of > 0.9921, indicating the method to be accurate and precise. Validation was further performed on pesticide exposure and control blood samples effectively. The developed method can be employed to estimate the levels of exposure in blood samples since the method has been found to be accurate and reliable under the European standard guidelines.
Report of the Nomenclature Committee for Fossils: 15
Authors: Herendeen Patrick S. 
Published: February 2022

SummaryThe following three generic names are recommended for conservation: Protophyllocladoxylon with a conserved type, Williamsonia with a conserved type and Zamites with a conserved type. The following two species names are recommended for conservation: Aspleniopteris difformis (Comptonia difformis) against Phyllites comptoniifolius and Williamsonia gigas T.M. Harris against W. gigas (Lindl. & Hutton) Carruth.
A new sectional classification of Lachenalia (Asparagaceae) based on a multilocus DNA phylogeny
Authors: Duncan Graham D. , Schlichting Carl D. , Forest Félix , Ellis Allan G. , Lemmon Alan R. , Lemmon Emily Moriarty , Verboom G. Anthony 
Published: February 2022

AbstractLachenalia (Asparagaceae; Scilloideae; Hyacintheae) is a large and morphologically diverse genus of more than 140 bulbous species endemic to southern Africa. Previous attempts to infer a well‐resolved and robustly supported phylogeny of Lachenalia using Sanger sequencing of candidate loci and/or morphological characters have been largely unsuccessful. Consequently, the current infrageneric classification is artificial, and there is a need to explore alternative avenues to produce a phylogenetic classification. In this paper, we present a novel phylogenetic hypothesis for Lachenalia inferred using maximum likelihood and coalescent‐based species tree estimation (ASTRAL) as applied to 378 hybrid‐enrichment loci. Our tree is well resolved and well supported, providing strong support for a monophyletic radiation of the genus in southern Africa and a solid foundation for a revised infrageneric classification. The well‐supported placement of L. isopetala Jacq. as sister to Lachenalia + Massonia supports the establishment of a new monotypic genus, Pseudolachenalia, to accommodate this species. Conversely, the inclusion of species previously classified as Polyxena within the Lachenalia clade supports the transfer of these species to Lachenalia. Within Lachenalia, the delimitation of subgenera and sections is complicated by the highly imbalanced character of the phylogeny and by the high levels of homoplasy shown by most morphological characters traditionally used to delimit species in this group. Nonetheless, we propose an infrageneric taxonomy comprising 10 morphologically distinct, monophyletic sections. The largest of these, L. sect. Lachenalia, is further divided into 13 more‐or‐less diagnosable, monophyletic subsections. Keys to the sections of Lachenalia, and to the subsections of L. sect. Lachenalia, are provided.
Investigating the dimensions of modeling competence among preservice science teachers: Meta‐modeling knowledge, modeling practice, and modeling product
Authors: Göhner Maximilian Felix , Bielik Tom , Krell Moritz 
Published: February 2022

AbstractWorldwide, teachers are expected to engage their students in authentic practices, like scientific modeling. Research suggests that teachers experience challenges when integrating modeling in their classroom instruction, with one explanation that teachers themselves lack the necessary modeling competence. Currently, theoretical conceptualizations structure the modeling competence into three dimensions: meta‐modeling knowledge, modeling practice, and modeling products. While each of these dimensions is well researched on its own and the three dimensions are commonly expected to be highly positively related, studies investigating their specific relationships are widely lacking. Aiming to fill this gap, the present study investigated the meta‐modeling knowledge, modeling practice, and modeling products of 35 secondary preservice biology teachers engaging in a black box modeling task. Data were collected with an established pen‐and‐paper questionnaire consisting of five constructed response items assessing meta‐modeling knowledge and by videotaping the participants engaging in the black box modeling task. Herein, the three dimensions of modeling competence were operationalized as five variables including decontextualized and contextualized meta‐modeling knowledge, complexity, and homogeneity of the modeling processes and a modeling product score. In contrast to our expectations and common assumptions in the literature, significant relationships between the five variables were widely lacking. Only the complexity of the modeling processes correlated significantly with the quality of the modeling products. To investigate this relationship further, a qualitative in‐depth analysis of two cases is presented. Implications for biology teacher education are discussed.
Inguinal herniorrhaphy in goat: The novel way of using vest‐over‐pants closure technique
Authors: Kitessa Jiregna Dugassa , Merga Abebe Fromsa , Afata Abebe Wirtu , Feyisa Cheru Telila 
Published: March 2022

AbstractThe present case report aims to describe surgical repair and management of inguinal hernia in a 2‐month‐old, 5 kg, female kid admitted to the Veterinary Teaching Hospital. General and clinical examination revealed a large swelling in the left groin, progressing to the groin area that could be reduced to the ring. After aseptic preparation of the surgical site, stabilisation with diazepam at 0.1 mg/kg and circular infiltration with 2% lidocaine hydrochloride at 3.4 mg/kg, a sharp linear incision was made in the skin and subcutaneous tissue over the swelling slightly lateral to the udder. Then the contents were identified and relocated. From there, the ring was renewed and sutured with the appropriate threads and patterns followed by muscle layer and skin. After the operation, the kid was administered with antibiotics and analgesics intramuscularly for 3 days, incision site was dressed with diluted chlorhexidine solution and the kid successfully recovered without complications.
Anaesthetic management of a dog with severe pulmonary stenosis and R2A right coronary artery anomaly undergoing placement of a hybrid transventricular pulmonary stent
Authors: Cambruzzi Martina , Borgeat Kieran , MacFarlane Paul 
Published: February 2022

AbstractA 7‐month‐old, 12.2 kg, male, neutered, English bulldog with severe pulmonary stenosis and R2A right coronary artery anomaly was anaesthetised for placement of hybrid right ventricle to pulmonary artery stent. An alfentanil bolus (10 μg/kg intravenously) was used as premedication. Anaesthesia was induced with midazolam (0.2 mg/kg) and etomidate (1 mg/kg) intravenously, and maintained with sevoflurane in 100% oxygen. Perioperative analgesia was achieved combining locoregional techniques with intravenous analgesics. The main intraoperative complications were hypotension, bradycardia, ventricular premature complexes, ST‐segment depression and transient hypoxaemia. Lidocaine constant‐rate infusion (50 μg/kg/min) and magnesium sulphate constant‐rate infusion (5 mg/kg/h) were used to prevent arrhythmias during the cardiac manipulations and stent placement. Hypotension was treated with dobutamine and noradrenaline constant‐rate infusion. The use of different drugs and anaesthetic techniques (balanced anaesthesia) provided antinociception, muscle relaxation and appeared to be effective in preventing major cardiovascular complications.
Primary mediastinal spindle cell sarcoma in a dog
Authors: Lomas Daniel C. , Garrett Katrina , Taylor David , Havlicek Martin , Jenkins Paul L. 
Published: March 2022

AbstractSoft tissue sarcomas are frequently reported tumours in dogs and are most often located in the cutaneous and subcutaneous tissues. Primary thoracic soft tissue sarcomas are infrequently reported in veterinary literature. This case report describes the diagnosis and treatment of a primary mediastinal spindle cell sarcoma of a 7‐year‐old, male, neutered Labrador retriever. Staging was performed before surgery. Computed tomography revealed a large intrathoracic mass in the left ventral hemithorax. A left‐sided thoracotomy was performed and a large pedunculated mass originating from the caudal mediastinum was excised. Histopathology revealed a high‐grade, undifferentiated spindle cell sarcoma. Immunohistochemistry staining confirmed the mesenchymal origin of the mass. Adjuvant chemotherapy was administered. Thoracic radiology was performed 38 days after surgery and revealed pleural effusion and mass effect in the caudal thorax. The patient was euthanased 66 days after surgery due to acute respiratory distress.
Anaesthetic management for cardiac 3D electro‐anatomical mapping and radiofrequency catheter ablation in a horse with sustained atrial tachycardia
Authors: Phillips Victoria , Schauvliege Stijn , Decloedt Annelies , Van Steenkiste Glenn , van Loon Gunther 
Published: March 2022

AbstractAtrial arrhythmias in horses are common, and novel catheter‐based treatment techniques require the horse to be under general anaesthesia. A 3‐year‐old gelding, weighing 517 kg, presented for cardiac three‐dimensional electro‐anatomical mapping and radiofrequency ablation for treatment of sustained atrial tachycardia. The current case report describes a suitable anaesthetic protocol that included medetomidine and methadone as premedication, a combination of ketamine and diazepam for co‐induction of anaesthesia and maintenance with isoflurane vaporised in an oxygen/air mixture with constant‐rate infusions of medetomidine and lidocaine. Total anaesthesia time was 205 minutes. The current protocol did not negatively impact on the procedure performed, provided good haemodynamic stability for several hours and enabled a smooth, good‐quality recovery. The horse developed a triceps myopathy postoperatively, which was successfully treated and the horse was discharged 18 days following treatment.
Weather, climate, and agriculture: Historical contributions and perspectives from agricultural meteorology
Authors: Parolini Giuditta 
Published: February 2022

AbstractAll over the world, farming communities need to adapt to a changing climate. At the same time, they are confronted by the necessity to increase food availability for a growing population, but also to ensure a sustainable use of natural resources. In this process, agriculture is not just the fiend responsible for an increase in greenhouse gas emissions, nor the victim of rising temperatures and extreme weather events. Agriculture is also an ally in climate change mitigation and adaptation because the selection of ad hoc crop varieties and livestock can lower the environmental impact of farming and the implementation of better management practices can promote soil conservation. Whether agriculture will have a positive or a negative impact on climate change adaptation and mitigation will depend on the rural policies implemented, but it will also be contingent on an adequate understanding of the interconnections existing between weather, climate, and farming. This review explores such interconnections by focusing on the history of agricultural meteorology, which is the research field that studies the impact of weather and climate on crops, livestock, farming operations, and plant and animal pests and diseases. The article discusses stakeholders, institutions, and main developments in agricultural meteorology, and describes how the agenda of agricultural meteorology has shifted over time. At the beginning of the 20th century, research in agricultural meteorology focused on increasing the profitability of farming. In the 21st century, instead, the main goal of agricultural meteorology is to ensure food security and guarantee sustainability.This article is categorized under:Climate, History, Society, Culture > Disciplinary Perspectives