bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness of two screening strategies based on Chinese diabetes risk score for pre-diabetes in China
Authors: Hao Jingjing , Yao Qiang , Lin Yidie , Sun Yue , Zhang Baiyang , Hu Meijing , Zhang Jing , Zhao Ningxuan , Pei Jiao , Liu Zhonghua , Zhu Cairong 
Published: November 2022

ObjectiveStudies have shown that screening for pre-diabetes mellitus (pre-DM) is essential to prevent type 2 diabetes mellitus (T2DM). This study evaluates the cost-effectiveness of two screening strategies that apply the Chinese Diabetes Risk Score (CDRS) to screen for pre-DM in China.MethodsA Markov microsimulation model was conducted from a social perspective, and the input parameters were obtained from published literature or publicly available data. Two screening strategies for pre-DM based on CDRS were built and compared with the control group to determine the cost-effective strategy. The screening strategy of the control group was screening for pre-DM by fasting plasma glucose (FPG) test in adults undergoing annual health examination and no screening in adults without an annual health examination (status quo). Two screening strategies were strategy 1: screening for pre-DM using CDRS in all adults (including with or without an annual health examination); and strategy 2: supplemental self-screening for pre-DM using CDRS in adults without an annual health examination, based on the status quo. We focus on the cumulative prevalence of T2DM and the incremental cost-effectiveness ratio which signifies the cost per case of T2DM prevented. We also evaluated the cost-effectiveness from the health system perspective. One-way and probabilistic sensitivity analyses were conducted to verify the robustness of the results.ResultsThe costs a case of T2DM prevented for strategy 1 compared with the control group and strategy 2 were $299.67 (95% CI 298.88, 300.46) and $385.89 (95% CI 381.58, 390.20), respectively. In addition, compared with the control group, the cost of strategy 2 to prevent a case of T2DM was $272.23 (95% CI 271.50, 272.96).ConclusionsScreening for pre-DM using CDRS in all adults was the most cost-effective health policy. We suggest that medical institutions replace FPG with CDRS for pre-DM screening; at the same time, self-screening for pre-DM using CDRS is widely promoted among adults without an annual health examination. There were still some disputes about how CDRS is included in the health examination projects, so strategy 2 should be considered as an alternative screening strategy. Findings provide a reference for the application of the CDRS in pre-DM screening and contribute to T2DM prevention.
Global trends and hotspots in research on osteoporosis rehabilitation: A bibliometric study and visualization analysis
Authors: Wang Liqiong , Jiang Jiaojiao , Li Yi , Huang Jinming , Wang Renjie , Liang Yuxiang , He Chengqi , Liu Shaxin 
Published: November 2022

BackgroundThe field of rehabilitation medicine plays an essential role in the comprehensive management of osteoporosis and its consequences. The benefits of therapeutic exercise are increasingly being recognized in this area, which receives an increasing number of publications. this study was designed to comprehensively identify collaborative networks, parse and track research trends, spotlight present hotspots, and accurately predict frontiers and focus on the health topics related to osteoporosis rehabilitation.MethodsThis research adopted computer retrieval of osteoporosis rehabilitation-related research published in the Web of Science Core Collection (WoSCC) from inception to June 14, 2022. The bibliometric visualization and comparative analysis involving countries, institutions, journals, authors, references, and keywords were performed using the CiteSpace and VOSviewer software.ResultsA total of 3,268 articles were included, and the number of articles published each year has demonstrated a steady increase. The United States and the University of Melbourne were the highest productive country and institution, with 1,325 and 87 articles, respectively. The journal of osteoporosis international has published the greatest number of articles, with 221 publications, and the journal of bone and mineral research ranked first in the co-citation counts (cited by 11,792 times). The most productive and highly-cited authors were Heinonen A and Cummings S, with 35 publications and 680 citations.ConclusionsAt present, “physical activity,” “weight bearing exercise,” “muscle strength,” “whole body vibration,” “postmenopausal women,” “older women,” children, men are the noteworthy research hot topics. Future research that focus on the major modes and parameters of physical activity/exercise for osteoporosis (including whole body vibration, weight bearing exercises, resistance training), targeted multicomponent training regimens, rehabilitation therapy for postmenopausal women, older women, children and men, osteoporosis related-sarcopenia and fractures, and mesenchymal stem cells are becoming frontiers and focus on the health topics related to osteoporosis rehabilitation in the upcoming years, which are worthy of further exploration.
Seafarers' mental health status and life satisfaction: Structural equation model
Authors: Baygi Fereshteh , Smith Andrew , Mohammadian Khonsari Nami , Mohammadi-Nasrabadi Fatemeh , Mahmoodi Zohreh , Mahdavi-Gorabi Armita , Qorbani Mostafa 
Published: November 2022

BackgroundA variety of factors influence seafarers' health. Such factors might affect their satisfaction with life.AimsTo examine the relationships between seafarers' mental health status and satisfaction with life by using a structural equation method.MethodsIn this survey, 470 seafarers were selected via convenience sampling method from two shipping companies. Validated questionnaires including Satisfaction with Life Scale (SWLS), generalized anxiety disorder-7 (GAD-7), Post-traumatic Stress Disorder-8 (PTSD-8), Patient Health Questionnaire-9 (PHQ-9), General Health Questionnaire-12 (GHQ-12), Perceived Health status and Depression-Anxiety-Stress scale-21 (DASS-21) were used to assess different aspects of well-being and life satisfaction. The stratified path analysis method was applied to analyze the data.Results439 seafarers (200 officers and 237 non-officers) with a mean age of 34.5 (SD: 8.05) participated in the current study. The GHQ score directly affected satisfaction with life in both officers (β = 0.35) and non-officers (β = 0.40). Also, perceived health status directly and indirectly affected satisfaction with life among officers (β = 0.19) and non-officers (β = 0.06). While officers working days per month indirectly impacted satisfaction with life through the general anxiety disorder, perceived health status, depression, anxiety, stress and current mental health. In non-officers, generalized anxiety disorder had the most potent indirect effects on satisfaction with life through perceived health status and current mental health.ConclusionPerceived health status, directly and indirectly, affected seafarers' satisfaction with life. Measures should be taken in order to improve seafarers' perceived health status and its effects on satisfaction with life.
Chemical Composition, Antioxidant and Antimicrobial Effects of Essential Oils Extracted from Two New Ocimum basilicum L. Varieties
Authors: Stan (Tudora) Cătalina , Nenciu Florin , Muscalu Adriana , Vlăduț Valentin Nicolae , Burnichi Floarea , Popescu Carmen , Gatea Florentina , Boiu-Sicuia Oana Alina , Israel-Roming Florentina 
Published: November 2022

Recent agricultural research aims to identify novel applications for plant extracts as efficient defenses against weeds, insects, or phytopathogenic agents. The main goal of the present study was to evaluate two new varieties of basil (Ocimum basilicum L., fam. Lamiaceae), Yellow basil, “Aromat de Buzau” variety and Red-violet basil, “Serafim” variety. The basil varieties were studied under different aspects regarding biochemical characterization using GC-MS, antioxidant activity evaluated under three methods (DPPH, ABTS, FRAP), and antimicrobial properties (for three G-bacteria: Perctobacterium carotovorum, Pseudomonas marginalis, Pseudomonas syringae and three phytopathogenic fungi: Rhizoctonia solani, Fusarium oxysporum, Botrytis cinerea). The results showed that linalool (39.28%; 55.51%), estragole (31.48%; 9.78%), and eugenol (5.42%; 7.63%) are the main compounds identified in the extracts, validating the high antioxidant activity of the studied essential oils and floral waters. When applied in high concentrations, essential oils have shown a potential bactericidal effect on P. carotovorum as well as a potential fungicidal effect on R. solani and B. cinerea.
Genome-Wide Identification of ATG Gene Family Members in Fagopyrum tataricum and Their Expression during Stress Responses
Authors: Fang Yue , Wang Shuang , Wu Hula , Li Chenglei , Zhao Haixia , Chen Hui , Wang Xiaoli , Wu Qi 
Published: November 2022

Abiotic stresses such as drought and salinity are major environmental factors limiting plant productivity. Autophagy-related genes are extensively involved in plant growth, development, and adverse stress responses, which have not yet been characterized in Tartary buckwheat (Fagopyrum tataricum, TB). In this study, we verified that drought stress could induce autophagy in TB roots. Next, 49 FtATGs in the whole genome of TB were identified. All FtATGs were randomly distributed in 8 known chromosomes, while 11 FtATGs were predictably segmental repeats. As the core component of autophagy, there were 8 FtATG8s with similar gene structures in TB, while FtATG8s showed high expression at the transcription level under drought and salt stresses. The cis-acting element analysis identified that all FtATG8 promoters contain light-responsive and MYB-binding elements. FtATG8s showed a cell-wide protein interaction network and strongly correlated with distinct stress-associated transcription factors. Furthermore, overexpression of FtATG8a and FtATG8f enhanced the antioxidant enzyme activities of TB under adverse stresses. Remarkably, FtATG8a and FtATG8f may be vital candidates functioning in stress resistance in TB. This study prominently aids in understanding the biological role of FtATG genes in TB.
CRISPR/Cas9-Mediated Editing of AGAMOUS-like Genes Results in a Late-Bolting Phenotype in Chinese Cabbage (Brassica rapa ssp. pekinensis)
Authors: Shin Yun-Hee , Lee Hyun-Min , Park Young-Doo 
Published: November 2022

Due to the sudden change in temperature in spring, Chinese cabbage, a leafy vegetable cultivated for consumption, loses its commercial value due to the onset of bolting—the phenomenon of switching from vegetative to reproductive growth. In this study, we applied clustered regularly interspaced short palindromic repeats/(CRISPR)-associated system 9 (CRISPR/Cas9) technology to analyze AGAMOUS-like genes. We performed functional analysis of AGL19 and AGL24 genes related to bolting and flowering using CRISPR/Cas9-mediated Chinese cabbage transformation. Single-guide RNA (sgRNA) sequences were created with a low off-targeting probability to construct gene-editing vectors. Agrobacterium-mediated transformation was conducted, and tentative E0 AGL-edited lines were analyzed using molecular biotechnological methods. Two AGL19-edited lines with nucleotide sequence mutations in the target sequence of the AGL19 genes and four AGL24-edited lines with nucleotide sequence mutations in the target sequence of the AGL24 genes showed particularly late bolting compared to the inbred line ‘CT001.’ Generational progression using bud pollination obtained T-DNA-free E1 AGL-edited lines, which also showed late bolting. The loss of function of the AGL protein was caused by the occurrence of an indel mutation in the AGL19 and AGL24 genes, which results in an early stop codon. Furthermore, frameshift mutations led to structural changes and the introduction of an early stop codon in the AGL19 and AGL24 proteins. Our results indicate that CRISPR/Cas9-mediated editing of AGAMOUS-like genes results in a late-bolting phenotype and that CRISPR/Cas9 is a useful technology for analyzing gene function in Chinese cabbage (Brassica rapa ssp. pekinensis).
Clinical Application of the Computed-Tomography-Based Three-Dimensional Models in the Surgical Planning and Intraoperative Navigation of Ureteropelvic Junction Obstruction Complicated with Renal Calculi
Authors: Xiong Shengwei , Zheng Mengmeng , Liu Chunlin , Yang Kunlin , Li Zhihua , Zhang Lei , Tian Ye , Zhou Liqun , Li Xuesong 
Published: November 2022

Background and Objectives: To clinically validate the computed tomography (CT)-based three-dimension (3D) model for treatment planning and intraoperative navigation of ureteropelvic junction obstruction (UPJO) complicated with renal calculi. Materials and Methods: We retrospectively collected the data of 26 patients with UPJO and renal calculi who were surgically treated in our institution from January 2019 to December 2021. Before surgery, 3D models based on preoperative CT scans were constructed in all patients. Additionally, the patients were divided into three groups according to the results of 3D models, distinguished by different treatment of renal calculi, that is, left untreated (1), pyelolithotomy (2), and endoscopic lithotomy (3). The quantitative analysis of renal calculi parameters, and perioperative and follow-up data were compared. Results: The mean number of involved renal calyces (p = 0.041), and the mean maximum cross-sectional area (p = 0.036) of renal stones were statistically different among the three groups. There were no significant differences among the three groups in the mean operative time, mean estimated blood loss, mean pararenal draining time, and mean hospital stay. The intraoperative stone clearance rates were 100% (11/11) and 77.8% (7/9) in group 2 and group 3, respectively. The trends of increased estimated glomerular filtration rate and decreased creatinine on the average levels after surgery were observed, although these changes were not statistically significant. At a mean follow-up of 19.4 ± 6.4 months, the overall surgical success rate of the UPJO was 96.2% (25/26), and the overall success rate of renal calculi removal was 80.8% (21/26). Renal stones in 66.7% (4/6) of patients in group 1 spontaneously passed out. Conclusions: Preoperative 3D CT models have exact clinical value in the surgical planning and intraoperative navigation of UPJO patients complicated with renal calculi.
In Vitro Investigation of the Anticancer Properties of Ammodaucus Leucotrichus Coss. & Dur.
Authors: Lenzi Monia , Turrini Eleonora , Catanzaro Elena , Cocchi Veronica , Guerrini Alessandra , Hrelia Patrizia , Gasperini Sofia , Stefanelli Claudio , Abdi Bellau Mohamed Lamin , Pellicioni Valentina , Tacchini Massimo , Greco Giulia , Fimognari Carmela 
Published: November 2022

Little is known about the pharmacological activity of Ammodaucus leucotrichus Coss. & Dur., a small annual species that grows in the Saharan and sub-Saharan countries. In the present study, we investigated whether the standardized ethanolic extract of A. leucotrichus fruits and R-perillaldehyde, a monoterpenoid isolated from A. leucotrichus fruits, are able to affect different processes involved in different phases of cancer development. In particular, we explored their genoprotective, proapoptotic, antiproliferative, and cytodifferentiating potential on different human cell models. We analyzed the genoprotective and proapoptotic activity on human lymphoblast cells (TK6) using the micronucleus test, and the cytodifferentiation effects on human promyelocytic cells (HL60) through the evaluation of different markers of differentiation forward granulocytes or monocytes. The results showed that the extract and perillaldehyde were able to induce apoptosis and protect from clastogen-induced DNA damage. To our best knowledge, this is the first report on the ability of A. leucotrichus and perillaldehyde to induce apoptosis and protect DNA from the toxicity of different compounds. Data reported in this work are the starting point for their pharmacological use. Going forward, efforts to determine their effects on other events associated with cancer development, such as angiogenesis and metastasization, will provide important information and improve our understanding of their potential in cancer therapy.
La conquête des Motilones du Huallaga Central aux XVIIe et XVIIIe siècles
Authors: Scazzocchio Françoise 
Published: November 2022

Résumé
L’effet primordial de la conquête de la Montaña péruvienne du Nord-Ouest a été la diminution considérable de la population indigène, qui selon les rapports jésuites fut réduite en 1762 à un cinquième de ce qu’elle était en 1650, à la suite d’épidémies et d’expéditions punitives.
Le schéma de l'avance espagnole fut le démembrement d’un grand nombre de petites “nations” isolées pour les rassembler en “reducciones”, villages ou petites villes où les indiens étaient soumis à des autorités politiques et religieuses dans le cadre de la société et de l'économie coloniales. Dans la région du Huallaga Central plusieurs groupes selvicoles distincts appelés génériquement Motilones furent rattachés au fort de Lamas au XVIIe et confondus dans un moule culturel colonial de caractère andin. En deux siècles (XVIIe et XVIIIe) se constitua une minorité quechuaphone aux traits particuliers, à laquelle est généralement attribuée au Pérou une origine légendaire Chanca.
L’objet de cet article est de présenter brièvement les principales sources qui retracent la formation historique de la minorité Lamista quechua. Cette formation, qui est comparable à celle d’autres minorités quechua de la forêt en Équateur et au nord du Pérou, exemplifie un modèle de domination qui fut projeté sur toute la Montaña pendant l’époque coloniale mais ne fut véritablement consolidé que sur les confins andins.
Qoyllur Rit’i, an inca fiesta of the Pleiades: reflections on time & space in the Andean World
Authors: Randall Robert 
Published: November 2022

Resumen
La fiesta de Qoyllur Rit’i, que se presenta todos los años para el tiempo de Corpus Cristi en un valle aislado cerca del Cusco, es todavía dominada por creencias indígenas. En este trabajo se intenta demostrar que la fiesta es de origen precolombino y que originalmente se celebraba el tránsito de un año al próximo, del mundo pasado al presente. Este concepto de tránsito es luego examinado en el contexto de las ideas del espacio y del tiempo, tanto de los incas como de la actualidad andina.
Approche comparative des mécanismes d’évolution et de consolidation des quartiers populaires à Quito et à Guayaquil
Authors: Godard Henri R. 
Published: November 2022

Resumen
El objetivo de este artículo es comparar la evolución y la consolidación de los barrios populares de las dos ciudaues principales del Ecuador y tratar de obtener conclusiones procedentes.
El estudio comparativo se desarrolla a dos niveles. De un lado, analizaremos los mecanismos de consolidación, tanto en la ciudad capital como en el puerto principal; insistiremos en los puntos semejantes y las diferencias que pueden explicar estos procesos.
De otro lado, compararemos las zonas de estudio, agrupadas de acuerdo a su período de formación; así será posible afinar las conclusiones anteriormente expuestas y destacar elementos que permitan “cuantificar” el grado de evolución y acercarse a la noción de “velocidad” de consolidación en cada caso.
Aproximación psico-antropológica a los mitos andinos
Authors: Hernández Max , Lemlij Moisés , Millones Luis , Péndola Alberto , Rostworowski Maria 
Published: November 2022

Résumé
Cette étude utilise une nouvelle stratégie d’analyse des mythes andins. Il s’agit d’en faire l’approche à partir d’un dialogue interdisciplinaire qui permette de relire les textes en tant que document historique et version orale, indépendamment de la véracité des renseignements qui sont rapportés. Ont été sélectionnés pour cet essai les récits de l’origine du Tawantinsuyu (les frères Ayar), de l’expansion de l’Etat (la guerre des Chankas), et d’une interprétation indigène de la Conquête (le Taki Onqoy). Les deux premiers constituent, à notre avis, une sorte de saga inca qui décrit les Incas à travers leur version officielle, le troisième étant l’idéologie messianique d’un mouvement surgi trente ans après la capture d’Atahualpa.
Le résultat de cette première recherche résume le travail de nombreuses sessions et prétend ouvrir la discussion sur le problème de la reconstruction des faits et des conduites et sur la méthodologie utilisée.
Mujer indígena, trabajo doméstico y cambio social en el virreinato peruano del siglo XVII: la ciudad de La Paz y el Sur andino en 1684
Authors: Glave Luis Miguel 
Published: November 2022

Abstract
Analysis of an exceptional padrón of the people subjected to domestic service in La Paz in 1684, reveals a process by which the Repúblicas of indians and Spaniards, in their changing relationship of dominance and subordination, sexualy selected the population destined to the most menial service of urban life. A relationship is discovered between the femenine life cycle and the system of domestic service which grew up in Andean society. A study of the relationship of the two elements, gender and ethnicity, will permit a new understanding of colonial society. Finally this study will establish what possible effects the biological and social reproduction revealed in this structure of relationships had for social and cultural change within the subjected population in colonial society.
Évolution tectono-sédimentaire du bassin de Talara (nord-ouest du Pérou)
Authors: Séranne Michel 
Published: November 2022

Résumé
Le bassin pétrolier de Talara, dans le nord-ouest du Pérou, est rempli par des séries terrigènes fluvio-deltaïques du Campanien à l’Eocène Supérieur. Cinq cycles de sédimentation (A, B, C, D, E) sont définis par des séquences grano-décroissantes d’approfondissement du bassin, à l’exception du cycle B qui résulte de la progradation du système fluviatile. L’activité tectonique distensive qui domine l’évolution du bassin et contrôle la nature et la répartition des sédiments est interrompue, pendant l’Eocène Moyen, lorsque des chevauchements vers le sud-est se mettent en place dans la série tertiaire décollée du socle. Au front des chevauchements actifs, se forment des olistolithes ainsi que des brèches syntectoniques. L’analyse de la déformation en avant des failles inverses montre que les chevauchements se faisaient vers le sud-est et qu’ils affectaient des sédiments peu lithifiés.
Acceso a la vivienda para la segunda generación de las barriadas de Lima
Authors: Driant Jean-Claude , Grey Carlos 
Published: November 2022

Abstract
In the old barriadas of the northern and southern zones of Lima (conos norte y sur) there has appeared a new demand for housing caused by the fact that the children of the original settlers have reached adulthood and are forming new families. Starting with the demographic and socio-economic description of these new families, this article seeks to identify their residential paths by analysing their present situation (dependance on their parents, still living at home, as tenants or in their own homes) and by evaluating the options they have for solving housing problem in the context of the Lima market —these include private sales, state housing programs, remaining in the old barriada or participation in new land invasions.