bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of Giardia and helminths in Western Europe at local K9 (canine) sites (DOGWALKS Study)
Authors: Drake Jason , Sweet Sarah , Baxendale Kingsley , Hegarty Evan , Horr Stephanie , Friis Hanne , Goddu Troy , Ryan William G. , von Samson-Himmelstjerna Georg 
Published: September 2022

Abstract
Background
Intestinal parasite contamination from infected dogs can place other dogs and humans at risk. A study was initiated to estimate the prevalence of canine intestinal parasitism by collecting fecal samples in cities across Western Europe.

Methods
Fresh fecal samples were collected from 2469 dogs visiting 164 parks in 33 cities across 12 countries. Each owner responded to a questionnaire focusing on their dog’s signalment and recent anthelmintic treatment history. The collected samples were examined for hookworms, whipworms, ascarids and Giardia using a coproantigen diagnostic immunoassay and microscopy following centrifugal flotation.

Results
Nematodes or Giardia were detected in at least one sample from 100% of cities and in 93.3% of parks. Nematodes were detected in 57% of parks. Overall, 22.8% of dogs tested positive for an intestinal parasite, with Giardia being the most commonly identified parasites (17.3% of dogs, 83.5% of parks). For nematode infection, 7.6% of all dogs tested positive, with 9.9% of dogs aged < 1 year infected, 7.7% of those aged 1–3 years, 7.3% of those aged 4–6 years and 6.6% of those aged ≥ 7 years. Among the nematodes detected, ascarids were the most prevalent (3.6% of dogs, parks, 28.7% of parks), being most common in dogs aged < 1 year but also present in older dogs, including those aged ≥ 7 years. Hookworms and whipworms were detected in 3.2% and 2.3% of dogs of all ages, respectively, and in 37.2% and 17.7% of parks, respectively. A larger proportion of fecal samples tested positive with the coproantigen immunoassay than with centrifugal flotation. Positive test results for Giardia were sevenfold higher when both diagnostic tests were used than when centrifugal flotation alone was used, and there were 60% more positive test results for nematodes when both tests were used than when flotation alone was used. Overall, 77.2% of owners reported previous anthelmintic treatment, among whom at least 62.7% failed to follow recommended treatment frequency. Dogs receiving anthelmintic within the previous month had a lower percentage of nematode infection than those in which > 1 month had passed since the previous dose.

Conclusions
The prevalence estimates of intestinal parasite infections in dogs reported here highlight the need for owner education concerning guidelines for regular testing and treatment, even in older dogs. Failure to adhere to guidelines can result in ongoing transmission of these infections, including those with zoonotic potential. Combining coproantigen immunoassay with centrifugal flotation for diagnostic testing and regular anthelmintic treatment are important measures for ensuring optimal intestinal parasite control.

Graphical Abstract
Static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline
Authors: Wang Qiang , Chen Ben , Zhong Xiaomei , Hou Le , Zhang Min , Yang Mingfeng , Wu Zhangying , Chen Xinru , Mai Naikeng , Zhou Huarong , Lin Gaohong , Zhang Si , Ning Yuping 
Published: September 2022

Abstract
Background
Subjective cognitive decline (SCD) is a putative Alzheimer’s disease (AD) precursor without objective neuropsychological deficits. The hippocampus plays an important role in cognitive function and emotional responses and is generally aberrant in SCD. However, previous studies have mainly focused on static functional connectivity (sFC) by resting-state functional magnetic resonance imaging (fMRI) in SCD individuals, and it remains unclear whether hippocampal dynamic functional connectivity (dFC) changes exist in SCD and whether those changes are associated with subtle changes in cognitive function or affect.

Methods
Seventy SCD patients and 65 healthy controls were recruited. Demographic data, comprehensive neuropsychology assessments, and resting-state fMRI data were collected. The bilateral anterior and posterior hippocampi were selected as seeds to investigate the static and dynamic functional connectivity alterations in SCD.

Results
Compared to healthy controls, subjects with SCD exhibited: (1) decreased sFC between the left caudal hippocampus and left precuneus; (2) decreased dFC variability between the bilateral caudal hippocampus and precuneus; (3) increased dFC variability between the bilateral rostral hippocampus and caudate nucleus; and (4) increased dFC variability between the left rostral hippocampus and left olfactory cortex. Additionally, the attention scores were positively correlated with dFC variability between the left posterior hippocampus and left precuneus, and the dFC variability between the bilateral anterior hippocampus and caudate nucleus was positively correlated with depression scores and negatively correlated with global cognition scores.

Conclusion
SCD individuals exhibited abnormal sFC and dFC in the anterior-posterior hippocampus, and abnormal dFC was more widespread than abnormal sFC. A combination of sFC and dFC provides a new perspective for exploring the brain pathophysiological mechanisms in SCD and offers potential neuroimaging biomarkers for the early diagnosis and intervention of AD.
Morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota
Authors: Rehman Ata Ur , Khan Asif Iqbal , Xin Yi , Liang Wang 
Published: September 2022

AbstractEdible mushrooms have now been suggested as promising sources of biological functional ingredients and are the subject of the most recent nutrition research and novel functional foods. Polysaccharides from mushrooms exhibit impressive biological effects, notably against obesity. Obesity is a chronic metabolic disorder characterized by chronic inflammation, gut dysbiosis, and hyperpermeability of the colon. Here, we prove that mushrooms Morchella esculenta polysaccharide (MEP) effects on HFD-induced obesity, colonic inflammation, and gut microbiota dysbiosis. Our findings demonstrate MEP supplementation attenuates obesity parameters and reduces inflammation in the colon via regulation of Toll-like receptor 4 (TLR4), nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and inactivation of nuclear factor kappa B (NF-κB). Furthermore, MEP administration restores gut microbiota dysregulation by ameliorating Firmicutes to Bacteroidetes proportion as well as enhancing beneficial bacteria, like Lactobacillus, and inhibiting pathogenic bacteria like Enterococcus. MEP improves gut integrity by increasing tight junction proteins (TJs) and reducing endotoxin levels by controlling Lipopolysaccharide (LPS) in HFD-induced obese mice. These results demonstrated the therapeutic efficacy of MEP in attenuating HFD-induced obesity via regulating inflammatory cascades, ameliorating the gut microbiome, and modulating gut integrity.
Unraveled roles of Cav1.2 in proliferation and stemness of ameloblastoma
Authors: Li Shujin , Lee Dong-Joon , Kim Hyun-Yi , Kim Jun-Young , Jung Young-Soo , Jung Han-Sung 
Published: September 2022

AbstractBackgroundTranscriptome analysis has been known as a functional tool for cancer research recently. Mounting evidence indicated that calcium signaling plays several key roles in cancer progression. Despite numerous studies examining calcium signaling in cancer, calcium signaling studies in ameloblastoma are limited.ResultsIn the present study, comparative transcriptome profiling of two representative odontogenic lesions, ameloblastoma and odontogenic keratocyst, revealed that Cav1.2 (CACNA1C, an L-type voltage-gated calcium channel) is strongly enriched in ameloblastoma. It was confirmed that the Ca2+influx in ameloblastoma cells is mainly mediated by Cav1.2 through L-type voltage-gated calcium channel agonist and blocking reagent treatment. Overexpression and knockdown of Cav1.2 showed that Cav1.2 is directly involved in the regulation of the nuclear translocation of nuclear factor of activated T cell 1 (NFATc1), which causes cell proliferation. Furthermore, a tumoroid study indicated that Cav1.2-dependent Ca2+entry is also associated with the maintenance of stemness of ameloblastoma cells via the enhancement of Wnt/β-catenin signaling activity.ConclusionIn conclusion, Cav1.2 regulates the NFATc1 nuclear translocation to enhance ameloblastoma cell proliferation. Furthermore, Cav1.2 dependent Ca2+influx contributes to the Wnt/β-catenin activity for the ameloblastoma cell stemness and tumorigenicity. Our fundamental findings could have a major impact in the fields of oral maxillofacial surgery, and genetic manipulation or pharmacological approaches to Cav1.2 can be considered as new therapeutic options.
A large TV dataset for speech and music activity detection
Authors: Hung Yun-Ning , Wu Chih-Wei , Orife Iroro , Hipple Aaron , Wolcott William , Lerch Alexander 
Published: September 2022

AbstractAutomatic speech and music activity detection (SMAD) is an enabling task that can help segment, index, and pre-process audio content in radio broadcast and TV programs. However, due to copyright concerns and the cost of manual annotation, the limited availability of diverse and sizeable datasets hinders the progress of state-of-the-art (SOTA) data-driven approaches. We address this challenge by presenting a large-scale dataset containing Mel spectrogram, VGGish, and MFCCs features extracted from around 1600 h of professionally produced audio tracks and their corresponding noisy labels indicating the approximate location of speech and music segments. The labels are several sources such as subtitles and cuesheet. A test set curated by human annotators is also included as a subset for evaluation. To validate the generalizability of the proposed dataset, we conduct several experiments comparing various model architectures and their variants under different conditions. The results suggest that our proposed dataset is able to serve as a reliable training resource and leads to SOTA performances on various public datasets. To the best of our knowledge, this dataset is the first large-scale, open-sourced dataset that contains features extracted from professionally produced audio tracks and their corresponding frame-level speech and music annotations.
ABOS: an attention-based one-stage framework for person search
Authors: Chen Yuqi , Han Dezhi , Cui Mingming , Wu Zhongdai , Chang Chin-Chen 
Published: September 2022

AbstractPerson search is of great significance to public safety research, such as crime surveillance, video surveillance and security. Person search is a method of locating and identifying the queried person from a complete set of images. The main cause of false recall and missed detection in person search is the presence of person occlusion in the images. In order to improve the accuracy of person search when the person to be queried is occluded, this paper proposes an attention-based one-stage framework for person search (ABOS) using an anchor-free model as a baseline. The method uses the channel attention module to express different forms of occlusion and take full advantage of the spatial attention module to highlight the target region of the occluded pedestrians. These attention modules integrate deep and shallow features to guide the network to pay attention to the visible area of the occluded target and extract the semantic information of the pedestrians. Experimental results on CUHK-SYSU and PRW datasets show that the proposed person search method based on attention mechanism in this paper has better performance than existing methods, achieving 93.7$$\%$$
%
of mAP on CUHK-SYSU dataset and 46.4$$\%$$
%
of mAP on PRW dataset, respectively.
Material product life cycle analysis driven by industrial internet of things
Authors: Hu Qianwen , Yang He , Wu Jingjiao , Fang Hai , Zhang Li 
Published: September 2022

AbstractWith the fast expansion of the industrial Internet of Things (IIoT) in recent years, the requirement for high-speed, dependable, low-latency, and full-coverage IIoT has grown more pressing. Because of the complexities of the industrial environment and the distance of the specific plant site, communication quality is severely hampered. To overcome these challenges, the space-air-ground integrated network (SAGIN) is seen as a viable solution for the IIoT. This article examines SAGIN, IIoT, product life cycle management, and how to handle these difficulties using three methodologies. This paper explores SAGIN, IIoT, product life cycle management, and how three approaches can be used to deal with these difficulties. We first introduce the overall architecture of SAGIN and then use illustrations to explain the concept of product cycle data. The final experimental results demonstrate the effectiveness of our proposed method.
Effectiveness of a mobile-based educational intervention on self-care activities and glycemic control among the elderly with type 2 diabetes in southwest of Iran in 2020
Authors: Esferjani Shahla Vaziri , Naghizadeh Effat , Albokordi Mostafa , Zakerkish Mehrnoosh , Araban Marzieh 
Published: September 2022

Abstract
Background
The elderly constitute a large fraction of patients with type 2 diabetes worldwide. It has been well documented that the elderly’s adherence to disease control is not adequate. The present study aimed to evaluate the impact of a mobile-based educational intervention on self-care behaviors and glycemic control among elderly with type 2 diabetes.

Methods
The present study was conducted on 118 older people (59 in the intervention group and 59 in the control group) with type 2 diabetes who referred to Golestan Hospital in Ahvaz, southwest of Iran in 2020. Participants were randomly divided into experimental and control groups. Data were collected at baseline and after a 3-month follow-up. At baseline, the participants completed a valid and reliable multi-section questionnaire including items on attitude, the multidimensional scale of perceived social support (MSPSS), the Coping Self-Efficacy Scale (CSES), self-care constructs, and HBA1C. After analyzing the pre-test data, we designed a training program which was offered to the intervention group online via mobile phone in three online sessions. The control group, however, received no intervention except diabetes routine care. Data were analyzed using SPSS-15 at a significance level of 0.05.

Results
Before the intervention, the mean scores of CSES, attitudes towards self-care, MSPSS, and self-care were not statistically significant between study groups (P > 0.05), but after intervention, the study found significant differences between the groups in terms of CSES, attitude, MSPSS, and self-care (P = 0.001). Furthermore, after implementation of the intervention, the mean value of HbA1C in the intervention group was significantly less than that of the control group (7.00 vs. 7.32%) (P = 0.001).

Conclusion
The present results indicated that implementing an educational intervention via mobile phone can improve self-care practice and reduce HbA1C in the elderly with type 2 diabetes. The study also showed a moderate to large effect on the outcome variables. However, further studies with longer follow-up periods are recommended to confirm the results.
Effects of short-term repeated sprint training in hypoxia or with blood flow restriction on response to exercise
Authors: Giovanna Margaux , Solsona Robert , Sanchez Anthony M. J. , Borrani Fabio 
Published: September 2022

AbstractThis study compared the effects of a brief repeated sprint training (RST) intervention performed with bilateral blood flow restriction (BFR) conditions in normoxia or conducted at high levels of hypoxia on response to exercise. Thirty-nine endurance-trained athletes completed six repeated sprints cycling sessions spread over 2 weeks consisting of four sets of five sprints (10-s maximal sprints with 20-s active recovery). Athletes were assigned to one of the four groups and subjected to a bilateral partial blood flow restriction (45% of arterial occlusion pressure) of the lower limbs during exercise (BFRG), during the recovery (BFRrG), exercised in a hypoxic room simulating hypoxia at FiO2 ≈ 13% (HG) or were not subjected to additional stress (CG). Peak aerobic power during an incremental test, exercise duration, maximal accumulated oxygen deficit and accumulated oxygen uptake (VO2) during a supramaximal constant-intensity test were improved thanks to RST (p < 0.05). No significant differences were observed between the groups (p > 0.05). No further effect was found on other variables including time-trial performance and parameters of the force-velocity relationship (p > 0.05). Thus, peak aerobic power, exercise duration, maximal accumulated oxygen deficit, and VO2 were improved during a supramaximal constant-intensity exercise after six RST sessions. However, combined hypoxic stress or partial BFR did not further increase peak aerobic power.
LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease
Authors: Koper Marta J. , Tomé Sandra O. , Gawor Klara , Belet Annelies , Van Schoor Evelien , Schaeverbeke Jolien , Vandenberghe Rik , Vandenbulcke Mathieu , Ghebremedhin Estifanos , Otto Markus , von Arnim Christine A. F. , Balusu Sriram , Blaschko Matthew B. , De Strooper Bart , Thal Dietmar Rudolf 
Published: September 2022

AbstractIt has become evident that Alzheimer’s Disease (AD) is not only linked to its hallmark lesions—amyloid plaques and neurofibrillary tangles (NFTs)—but also to other co-occurring pathologies. This may lead to synergistic effects of the respective cellular and molecular players, resulting in neuronal death. One of these co-pathologies is the accumulation of phosphorylated transactive-response DNA binding protein 43 (pTDP-43) as neuronal cytoplasmic inclusions, currently considered to represent limbic-predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC), in up to 70% of symptomatic AD cases. Granulovacuolar degeneration (GVD) is another AD co-pathology, which also contains TDP-43 and other AD-related proteins. Recently, we found that all proteins required for necroptosis execution, a previously defined programmed form of neuronal cell death, are present in GVD, such as the phosphorylated necroptosis executioner mixed-lineage kinase domain-like protein (pMLKL). Accordingly, this protein is a reliable marker for GVD lesions, similar to other known GVD proteins. Importantly, it is not yet known whether the presence of LATE-NC in symptomatic AD cases is associated with necroptosis pathway activation, presumably contributing to neuron loss by cell death execution. In this study, we investigated the impact of LATE-NC on the severity of necroptosis-associated GVD lesions, phosphorylated tau (pTau) pathology and neuronal density. First, we used 230 human post-mortem cases, including 82 controls without AD neuropathological changes (non-ADNC), 81 non-demented cases with ADNC, i.e.: pathologically-defined preclinical AD (p-preAD) and 67 demented cases with ADNC. We found that Braak NFT stage and LATE-NC stage were good predictors for GVD expansion and neuronal loss in the hippocampal CA1 region. Further, we compared the impact of TDP-43 accumulation on hippocampal expression of pMLKL-positive GVD, pTau as well as on neuronal density in a subset of nine non-ADNC controls, ten symptomatic AD cases with (ADTDP+) and eight without LATE-NC (ADTDP−). Here, we observed increased levels of pMLKL-positive, GVD-exhibiting neurons in ADTDP+ cases, compared to ADTDP− and controls, which was accompanied by augmented pTau pathology. Neuronal loss in the CA1 region was increased in ADTDP+ compared to ADTDP− cases. These data suggest that co-morbid LATE-NC in AD impacts not only pTau pathology but also GVD-mediated necroptosis pathway activation, which results in an accelerated neuronal demise. This further highlights the cumulative and synergistic effects of comorbid pathologies leading to neuronal loss in AD. Accordingly, protection against necroptotic neuronal death appears to be a promising therapeutic option for AD and LATE.
‘You don’t have to feel trapped’: architectural discourses of youth engagement in a community-based learning environment
Authors: Bloomfield Corey , Harreveld Bobby , Fisher Rickie 
Published: September 2022

AbstractThe rigid architectures inherent within formal schooling continue to influence young people’s disengagement from education. Globally and locally, policy makers have proposed education reform and innovation, politicians have legislated for education change, yet still the problem of disengagement remains. This paper investigates one community’s effort to support the reengagement in learning of young people aged 15–18 years in regional Australia through a flexible, online, community-based education program. Theoretically, this study used critical discourse as a way in to expose so as to explain dimensions of power and ideological positions as to what counts as learning. Critical ethnography as a methodology extended critical discourse’s explanatory authority to a naming of spatial and social architectures and their impact on the young people’s lives. Discourses of a braided curriculum, structural conviviality and emotional well-being were found to reduce some barriers to reengagement in learning; develop a shared, multi-disciplinary approach to reengagement; and be inclusive of young people’s emotional well-being as central to the reengagement process. At this time of pandemic induced online learning as the new normal on a global scale, young people who are already vulnerable due to individual, school, and socio-cultural marginalising conditions deserve research processes with outcomes valorising their voices and those who work with them.