bluuebunny/crossref_metadata_2025_split huggingface dataset:
COVID-19 Pandemisinde Semptomlar ve Vaka Profilinin Veri Madenciliği Yaklaşımıyla İncelenmesi
Authors: KARAHAN ADALI Gökçe 
Published: September 2022

Tüm dünyaya hızla yayılan Corona virüsü 2019 (COVID-19), SARS ve MERS salgınları sonrası görülen üçüncü koronavirüs salgını olarak tüm dünyayı etkisi altına almıştır. Virüs dünya çapında halk sağlığı için büyük bir tehdit olmaya devam etmektedir. Dünya sağlık örgütü tarafından pandemi ilan edilen bu salgın, insanların sağlığına, eğitimine, sosyalleşmelerine ve küresel ekonomiye çok büyük etkiler bırakan önemli bir halk sağlığı krizidir. COVID-19’a daha hızlı yanıt verebilmek için her yönüyle çalışmalar devam etmektedir. Bu kapsamda hastalığın seyrinde, hastaların benzer özellikleri taşıdıkları semptomlar ve iyileşme sürecine etkileri önem arz etmektedir.
Bu çalışma, COVID-19 hastaları arasında yaş, cinsiyet, hastalığın seyrinde görülen semptomlar, iyileşme ve ölüm durumunda etkili birliktelikleri ortaya çıkarmayı amaçlamaktadır. Çalışmada, sık görülen semptomları belirlemek ve demografik verilerin iyileşme sürecine etkilerini çıkarmak için birliktelik kuralı adı verilen ve yaygın olarak kullanılan makine öğrenimi tekniği R programlama dili kullanılarak uygulanmıştır.
Elde edilen kurallarda, salgına yakalanmada yaş faktörünün büyük ölçüde etken olduğu tespit edilmiştir. En belirgin semptom olarak ateş ortaya konmuştur. Ateş semptomunu takiben öksürük semptomunun hastalar arasında sıklıkla rastlandığı görülmektedir. Analizler sonucunda, ölüm oranlarında yaşlı bireylerin ve erkeklerin kadınlara göre daha çok kayıp verdiği tespit edilmiştir.
Herramientas digitales para la educación médica en el contexto del COVID-19
Authors: Alvarado-Rodríguez Yazlin , Galán-Rodas Edén 
Published: September 2022

Desde la declaratoria de pandemia por la Organización Mundial de la Salud, el 11 de marzo del 2020(1), en el mundo entero se decretaron estados de emergencia por las graves circunstancias que afectaban la vida de las personas a consecuencia de la enfermedad producida por el virus SARS-CoV-2 (COVID-19), siendo el aislamiento social obligatorio, la principal medida con la que se pretendió mantener en confinamiento a las personas junto a otras medidas sanitarias, sociales y económicas.
A la fecha (mayo 2022), en el mundo existen más de 531 millones de personas infectadas y más de 6 millones de fallecidos a causa de esta enfermedad(2), lo que ha significado un reto para la economía y los sistemas de salud de los países más afectados a nivel global. En ese contexto, otro escenario bastante afectado por la pandemia lo representa la educación, con el cierre de aulas en todos sus niveles, pero particularmente por la alta demanda y afectación de los sistemas de salud, la educación universitaria en carreras de ciencias de la salud y especialmente la educación médica.
Đánh giá tình trạng bệnh lý tai mũi họng sau nhiễm COVID-19 của học viên, sinh viên tại Học viện Quân y
Authors: Đỗ Lan Hương Đỗ Lan Hương , Nguyễn Thúy Nhường Nguyễn Thúy Nhường , Trần Quang Mạnh Trần Quang Mạnh , Nguyễn Vân Anh Nguyễn Vân Anh , Vũ Tùng Lâm Vũ Tùng Lâm , Nguyễn Phi Long Nguyễn Phi Long 
Published: September 2022

Mục tiêu: Mô tả một số đặc điểm bệnh lý tai mũi họng (TMH) sau nhiễm COVID-19 mức độ trung bình và nhẹ ở các học viên, sinh viên tại Học viện Quân y. Đối tượng và phương pháp: Nghiên cứu mô tả, cắt ngang có theo dõi trên 793 học viên, sinh viên bị nhiễm COVID-19 mức độ trung bình và nhẹ tại Học viện Quân y từ tháng 4/2021 - 6/2022. Kết quả: Triệu chứng khi nhiễm COVID-19: Ho 75,16%, ngạt mũi 74,53%, đau họng 73,01%, chảy dịch mũi 65,32%, ù tai 11,35%. Triệu chứng kéo dài sau nhiễm COVID-19 ho 34,55%, ngạt mũi 6,05%, mệt mỏi 6,94%, đau họng 7,57%, đau đầu 5,55%, sốt 0,38%. Thời gian trở lại sinh hoạt, học tập bình thường sau nhiễm COVID-19 từ 8 - 14 ngày 52,59%, trong vòng 7 ngày 40,82%. 66,0% học viên có nhu cầu đi khám và điều trị bệnh lý TMH sau nhiễm COVID-19. Một số triệu chứng ảnh hưởng nhiều và nghiêm trọng đến học tập sinh hoạt của học viên: Ho (9,08% và 2,02%), ngạt mũi (7,69% và 0,26%), chảy dịch mũi (7,94% và 0,38%), khàn tiếng (1,01% và 1,89%). Kết luận: Triệu chứng TMH được ghi nhận chủ yếu trong khoảng 7 ngày khi nhiễm COVID-19. Các triệu chứng này phần lớn kéo dài sau nhiễm COVID-19 và trong 1 tháng, không ảnh hưởng hoặc ảnh hưởng ít đến sinh hoạt và học tập của các học viên. Tuy nhiên, các triệu chứng có thể gây ảnh hưởng nhiều hoặc nghiêm trọng đến học tập và sinh hoạt của học viên và phần lớn học viên đều có nhu cầu được thăm khám và điều trị các bệnh lý TMH sau nhiễm COVID-19.
* Từ khóa: COVID-19; Hậu COVID-19; Triệu chứng tai mũi họng.
Assessment of clinical, paraclinical characteristics of patients receiving concomitant mitral and aortic valve replacement with On-X mechanical prosthesis at Bach Mai Hospital
Authors: Ngo Phi Long  , Duong Duc Hung  , Nguyen Truong Giang  
Published: September 2022

Objectives: To investigate clinical and paraclinical characteristics of patients undergoing concomitant mitral and aortic valve replacement with On-X mechanical valve at Bach Mai Hospital. Subjects and methods: This was a non-controlled, prospective, descriptive study on 100 patients with severe aortic and mitral diseases undergoing concomitant aortic and mitral valve replacement with On-X valve. Clinical and paraclinical parameters were selected based on Vietnam National Heart Association and ACC/AHA guidelines. Results: Clinical manifestations included history of rheumatic heart disease (70.0%), NYHA class II (36.0%), NYHA class III (64.0%), atrial fibrillation (67.0%). Echocardiography showed dilated left ventricle (LVEDd 55.2 ± 8.9 mm, LVEDs 37.3 ± 8.1 mm), preserved left ventricular ejection fraction (63.9 ± 9.5%), moderately pulmonary arterial hypertension (47.2 ± 13.8 mmHg), and dilated left atrium (53.8 ± 10.5 mm). Conclusion: Most patients undergoing concomitant On-X aortic and mitral prosthetic valve replacement presented with moderate and severe heart failure, dilated left ventricle and left atrium, and increased pulmonary arterial pressure.
* Keywords: Mitral and aortic valve replacement; On-X valve.
Evaluation of acid-thermal pretreatments and enzymatic saccharification to obtain fermentable sugars from the juice and bagasse of Agave salmiana leaves
Authors: Martínez-Hernández Sergio , Hernández-Mendoza Alonso Guadalupe , Ruiz-Leza Héctor Arturo , Ortiz-Ceballos Angel Isauro , Castro-Luna Alejandro Antonio , Láinez-González Magdiel 
Published: September 2022

This study presents the results of acid-thermal pretreatments and enzymatic saccharification for the production of fermentable sugars from the juice and bagasse of Agave salmiana leaves. In the acid-thermal pretreatment, H2SO4 was used while in the enzymatic saccharification the commercial enzyme Cellic Ctec2 (Novozyme) was used. In the results it was found that the best conditions of the acid thermal pretreatment (H2SO4 % (v/v) at 100 ° C for 30 min) for the juice generated a concentration of 43.65 ± 1.36 g/L of reducing sugars. In bagasse, the best conditions (H2SO4 % (p/v) at 120 ° C for 60 min) produced a concentration of 37.35 ± 1.65 g/L of reducing sugars in the hydrolysates. In the enzymatic saccharification at 15 FPU/g substrate and solids load of 10 % (p/v), a concentration of 87.37 ± 1.27 g/L of reducing sugars was obtained after 72 h. The results obtained demonstrate the potential of the integral use of bagasse and juices from the leaves of Agave salmiana as raw material to produce fermentable sugars.
Empresas y emprendimientos turísticos de la Región Este de Uruguay: una aproximación a su estado de situación en el contexto del COVID-19
Authors: Zorzi Mariciana , Bula Kristina , Bianchi Facundo , Campodónico Gabriela , Angelo Gabriela 
Published: September 2022

Este artículo presenta los resultados de una investigación desarrollada desde junio de 2020, mediante la aplicación de una encuesta a empresas y emprendimientos turísticos de la Región Este de Uruguay; con el objetivo de aproximarse a la situación de los mismos en el contexto de la emergencia sanitaria ocasionada por el COVID-19. Entre los resultados obtenidos se destaca que: la mayoría de las empresas consultadas cesaron sus actividades, dadas las dinámicas propias del territorio y/o por la emergencia sanitaria; gran parte de las empresas no accedieron a las medidas oficiales de contención y reactivación del sector y la mayoría de las empresas entiende que el turismo interno posibilitará su sostén a futuro.
Molten Globule Intermediate of Recombinant Human Growth Hormone: Stabilization with Surfactants
Authors: Bam Narendra B. , Cleland Jeffrey L. , Randolph Theodore W. 
Published: July 2002

AbstractWe demonstrate that a surfactant‐stabilized molten globule intermediate exists for recombinant human growth hormone (rhGH), is very hydrophobic, and tends to form aggregates. Characterization of this intermediate included equilibrium denaturation measured by electron paramagnetic resonance (EPR) and CD spectroscopy, assessment of aggregation during refolding, and fluorescence studies of its binding to the hydrophobic probe, 1‐anilinonapthalene‐8‐sulfonate (1,8‐ANS). We have found that at 4.5 M guanidinium hydrochloride (GuHCl), a molten globule intermediate of rhGH is stabilized and results in significant aggregation upon refolding. This intermediate is populated by the addition of the nonionic surfactant, Tween. This surfactant also reduces the extent of aggregation during refolding of rhGH from 4.5 M GuHCl. Overall, our studies reveal that rhGH forms a molten globule‐like intermediate during folding and this intermediate self‐associates. This self‐association is reduced upon formation of a Tween‐rhGH complex. Tween also binds to the native protein. Thus, nonionic surfactants such as Tween may act like molecular chaperones in facilitating protein folding while not altering the native conformation.
Primary cell culture and morphological characterization of canine dermal papilla cells and dermal fibroblasts
Authors: Bratka‐Robia Christine B. , Mitteregger Gerda , Aichinger Amanda , Egerbacher Monika , Helmreich Magdalena , Bamberg Elmar 
Published: July 2002

Abstract Skin biopsies were taken from female dogs, the primary hair follicles isolated and the dermal papilla dissected. After incubation in supplemented Amniomax complete C100 medium in 24‐well culture plates, the dermal papilla cells (DPC) grew to confluence within 3 weeks. Thereafter, they were subcultivated every 7 days. Dermal fibroblast (DFB) cultures were established by explant culture of interfollicular dermis in serum‐free medium, where they reached confluence in 10 days. They were subcultivated every 5 days. For immunohistochemistry, cells were grown on cover slips for 24 h, fixed and stained with antibodies against collagen IV and laminin. DPC showed an aggregative growth pattern and formation of pseudopapillae. Intensive staining for collagen IV and laminin could be observed until the sixth passage. DFB grew as branching, parallel lines and showed only weak staining for collagen IV and laminin.
Low‐dose misoprostol for the prevention of low‐dose aspirin‐induced gastroduodenal injury
Authors: Donnelly M. T. , Goddard A. F. , Filipowicz B. , Morant S. V. , Shield M. J. , Hawkey C. J. 
Published: July 2002

Introduction:The harmful effects of non‐steroidal anti‐inflammatory drugs (NSAIDs) on the gastric mucosa and the prophylactic effects of misoprostol are both dose‐dependent.Aim:To investigate whether a low‐dose of misoprostol is sufficient to prevent gastric mucosal injury caused by low‐dose aspirin.Methods:We conducted a double‐blind placebo controlled parallel group endoscopic study in 32 evaluable volunteers. The main outcome measure was erosive injury (ulcers and superficial erosions) in the gastric mucosa over 28 days.Results:Most subjects developed erosions on aspirin 300 mg daily. This was significantly reduced by misoprostol 100 μg daily. (Odds ratio 0.18, 95% CI: 0.07–0.48). There were no drug‐related or gastrointestinal adverse events in subjects receiving misoprostol.Conclusion:Misoprostol 100 μg daily can prevent low‐dose aspirin induced gastric mucosal injury without causing identifiable adverse effects.
Concomitant overdosing of other drugs in patients with paracetamol poisoning
Authors: Schmidt Lars E. , Dalhoff Kim 
Published: July 2002

Aims  Paracetamol is frequently involved in intended self‐poisoning, and concomitant overdosing of other drugs is commonly reported. The purpose of the study was to investigate further concomitant drug overdose in patients with paracetamol poisoning and to evaluate its effects on the outcome of the paracetamol intoxication.Methods  Six hundred and seventy‐one consecutive patients admitted with paracetamol poisoning were studied and concomitant drug intake was recorded. The relative risk of hepatic encephalopathy, death or liver transplantation, hepatic dysfunction, liver cell damage, and renal dysfunction associated with concomitant overdosing of other drugs was evaluated by multivariate analysis.Results  Concomitant drug overdose was found in 207 patients (31%, 95% confidence interval [CI] 27, 34%). Concomitant overdosing of benzodiazepines (99 cases), opioid analgesics (38 cases), acetylsalicylic acid (33 cases), and NSAID (32 cases) predominated. Concomitant benzodiazepine overdose was an independent risk factor in the development of hepatic encephalopathy (odds ratio [OR] 1.91; CI 1.00, 3.65) and renal dysfunction (OR 1.81; CI 1.00, 3.22). Concomitant overdosing of opioid analgesics was a protective factor in the development of hepatic encephalopathy (OR 0.26; CI 0.07, 0.96). Concomitant acetylsalicylic acid overdose was a risk factor in the development of hepatic encephalopathy (OR 4.87; CI 1.52, 15.7) and death or liver transplantation (OR 6.04; CI 1.69, 21.6). A tendency towards a more favourable outcome was observed in patients with concomitant NSAID overdose.Conclusions  Concomitant overdosing of benzodiazepines or analgesics is frequent in patients admitted with paracetamol poisoning. Concomitant benzodiazepine or acetylsalicylic acid overdose was associated with more severe toxicity, whereas concomitant overdosing of opioid analgesics was associated with less toxicity.
Reliability of sentinel lymph node biopsy for staging melanoma
Authors: Jansen L , Nieweg O E , Peterse J L , Hoefnagel C A , Valdés Olmos R A , Kroon B B R 
Published: July 2002

Abstract

Background
The aim of this study was to evaluate the reliability of sentinel lymph node biopsy for staging melanoma.

Methods
Two hundred consecutive patients with a cutaneous melanoma of at least 1·0 mm Breslow thickness, without palpable regional lymph nodes, were included from 1993 in a prospective cohort study in a single tertiary care hospital. One day after lymphoscintigraphy, sentinel node biopsy was performed, guided by a γ probe and patent blue dye. Lymph node dissection was performed only if metastasis was found in a sentinel node. Median follow-up was 32 (range 3–61) months. No patient was lost to follow-up.

Results
A sentinel node was removed in 199 of 200 patients (mean 2·2 nodes per patient). Forty-eight patients (24 per cent) had metastasis in a sentinel node. Fifteen patients developed recurrence after removal of a tumour-negative sentinel node; six relapsed in the previously mapped basin (false-negative rate 11 per cent (six of 54)). The overall survival at 3 years was 93 per cent if the sentinel node was negative and 67 per cent if it was positive. Sentinel node status and Breslow thickness were strong predictors of recurrence and survival. Minor complications were seen in 18 patients.

Conclusion
The sentinel node status was a strong prognostic factor, even with a false-negative rate of 11 per cent.
Comparing global models of terrestrial net primary productivity (NPP): overview and key results
Authors: Cramer W. , Kicklighter D. W. , Bondeau A. , Iii B. Moore , Churkina G. , Nemry B. , Ruimy A. , Schloss A. L. , Intercomparison ThE. Participants OF. ThE. Potsdam NpP. Model 
Published: July 2002

SummarySeventeen global models of terrestrial biogeochemistry were compared with respect to annual and seasonal fluxes of net primary productivity (NPP) for the land biosphere. The comparison, sponsored by IGBP‐GAIM/DIS/GCTE, used standardized input variables wherever possible and was carried out through two international workshops and over the Internet. The models differed widely in complexity and original purpose, but could be grouped in three major categories: satellite‐based models that use data from the NOAA/AVHRR sensor as their major input stream (CASA, GLO‐PEM, SDBM, SIB2 and TURC), models that simulate carbon fluxes using a prescribed vegetation structure (BIOME‐BGC, CARAIB 2.1, CENTURY 4.0, FBM 2.2, HRBM 3.0, KGBM, PLAI 0.2, SILVAN 2.2 and TEM 4.0), and models that simulate both vegetation structure and carbon fluxes (BIOME3, DOLY and HYBRID 3.0). The simulations resulted in a range of total NPP values (44.4–66.3 Pg C year–1), after removal of two outliers (which produced extreme results as artefacts due to the comparison). The broad global pattern of NPP and the relationship of annual NPP to the major climatic variables coincided in most areas. Differences could not be attributed to the fundamental modelling strategies, with the exception that nutrient constraints generally produced lower NPP. Regional and global NPP were sensitive to the simulation method for the water balance. Seasonal variation among models was high, both globally and locally, providing several indications for specific deficiencies in some models.
Genetic structure and differentiation of Plantago major reveals a pair of sympatric sister species
Authors: Morgan‐Richards M. , Wolff K. 
Published: July 2002

AbstractSeeds of the widespread weed Plantago major were collected from 10 European countries, as well as Trinidad and North America. The seed collections were from populations of two taxa which are ecologically rather than geographically separated and formally recognized as the subspecies Plantago major ssp. major and P.m. ssp. intermedia (also called P.m. ssp. pleiosperma). Eight polymorphic allozyme loci and 73 random‐primed DNA fragments were scored, as well as 11 morphological characters. Complete concordance between morphological traits and genetic data provides evidence that these two taxa, although very similar, are distinct species. They are both widespread, they are broadly sympatric and capable of interbreeding. However, slight morphological and ecological differences coincide with genetic clustering of populations from widely separated locations. In addition, P. major and P. intermedia differ in their population structure: P. intermedia has greater genetic diversity among populations and less genetic variance within populations than P. major. We suggest that differences between the two species in their levels of selfing may explain the distinctive genetic structure of each species. We hypothesize a link between selfing rate and lifespan of the two taxa. P. major is characterized by lower genetic variation among populations, a higher rate of outcrossing, longer lifespan and production of fewer seeds per seed capsule. P. intermedia is more highly structured with much differentiation among populations, a higher rate of inbreeding and it often grows as an annual.
The aquatic thrips Organothrips indicus Bhatti (Thysanoptera: Thripidae) in Queensland, and a new species, O. wrighti, from tropical Australia
Authors: Mound Laurence A 
Published: July 2002

AbstractThe genus Organothrips includes the only fully aquatic thrips, the two previously known species breeding under water in the surface mucous of several unrelated monocotyledonous plants. Organothrips indicus Bhatti is recorded in Australia for the first time, breeding on water hyacinth (Eichhornia crassipes) in a greenhouse near Brisbane. Structural variation within this population is discussed, and character states considered for distinguishing this species from the Pacific taro thrips, O. bianchii Hood. A new species, Organothrips wrighti, is described from Melville Island, Northern Territory and from Cape Tribulation, Queensland. This species has fully macropterous males and is probably not aquatic. The studies on Eichhornia also gave rise to two new distribution records; Salpingothrips aimotofus Kudo is newly recorded from Australia, and the Northern Hemisphere pest thripid Echinothrips americanus Morgan is newly recorded from Thailand.
Rigid ureteroscopy in pregnant women
Authors: Shokeir  , Mutabagani  
Published: July 2002

Objective To report our experience with rigid ureteroscopy in pregnant women.Patients and methods Ten pregnant women (mean age 25 years, sd 4.5, range 22–33) with ureteric stones were treated by ureteroscopy. The mean (sd, range) gestation time was 24 (6.5, 19–33) weeks. A standard rigid ureteroscope of 11.5 F was used in eight patients and 9.5 F in two. The procedure was carried out with no ureteric dilatation in three patients and with easy dilatation in seven. Fluoroscopy was not used before or during ureteroscopy in any case. Ultrasonography was available throughout the procedures for constant renal and obstetric monitoring.Results Mid and lower ureteric stones were extracted by basket or forceps in three patients and had to be disintegrated by ultrasound in two. Upper ureteric stones were displaced to the kidney, with placement of double‐pigtail ureteric stents, in three patients who were subsequently treated after delivery. Ureteric oedema was seen in one patient and the endoscopic findings were normal in the remaining patient. There were no obstetric complications. Two patients had a urinary tract infection and one complained of stent‐induced bladder irritation.Conclusions Rigid ureteroscopy is a safe and reliable method in the diagnosis and treatment of ureteric calculi during pregnancy. The procedure can be performed with ultrasonographic monitoring and without using fluoroscopy.
Interspecific Variation in RGR and the Underlying Traits among 24 Grass Species Grown in Full Daylight
Authors: Ryser P. , Wahl S. 
Published: July 2002

Abstract: A growth analysis was conducted with 24 central European grass species in full daylight to test whether traits underlying interspecific variation in relative growth rate (RGR) are the same in full daylight as they are at lower light, and whether this depends on the ecological characteristics of the studied species, i.e., their requirements with respect to nutrient and light availability.In contrast to studies with herbaceous species at lower light, net assimilation rate (NAR) contributed more than leaf area ratio (LAR) or specific leaf area (SLA) to interspecific variation in RGR. This was associated with a larger interspecific variation in NAR than found in experiments with lower light. Without the two most shade‐tolerant species, however, the contribution of LAR and its components to interspecific variation in RGR was similar or even higher than that of NAR.Leaf dry matter content correlated negatively with RGR and was the only component of LAR contributing in a similar manner to variation in LAR and RGR. There was a positive correlation between NAR and biomass allocation to roots, which may be a result of nutrient‐limited growth. RGR correlated negatively with biomass allocation to leaves. Leaf thickness did not correlate with RGR, as the positive effect of thin leaves was counterbalanced by their lower NAR.Low inherent RGR was associated with species from nutrient‐poor or shady habitats. Different components constrained growth for these two groups of species, those from nutrient‐poor habitats having high leaf dry matter content, while those from shady habitats had thin leaves with low NAR.