bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age-dependent sex differences in cardiometabolic risk factors
Authors: Zhernakova Daria V. , Sinha Trishla , Andreu-Sánchez Sergio , Prins Jelmer R. , Kurilshikov Alexander , Balder Jan-Willem , Sanna Serena ,   Lifelines Cohort Study, Franke Lude , Kuivenhoven Jan A. , Zhernakova Alexandra , Fu Jingyuan 
Published: September 2022

AbstractCardiometabolic diseases (CMDs) are a major cause of mortality worldwide, yet men and women present remarkable differences in disease prognosis, onset and manifestation. Here we characterize how sex differences in cardiometabolic risk factors vary with age by examining 45 phenotypes and 6 lifestyle factors in 146,021 participants of the Dutch population cohort Lifelines. We show that sex differences are present in 71% of the studied phenotypes. For 31% of these phenotypes, the phenotypic difference between sexes is dependent on age. CMD risk factors show various patterns of age-related sex differences, ranging from no difference for phenotypes such as body mass index (BMI) to strong age-modified sex differences for lipid levels. We also identify lifestyle factors that influence phenotypes in a sex- and age-dependent manner. These results highlight the importance of taking age into account when studying sex differences in CMDs.
Auditory Discrimination Elicited by Nonspeech and Speech Stimuli in Children With Congenital Hearing Loss
Authors: Yang Ying , Li Qiong , Xiao Yanan , Liu Yulu , Sun Kangning , Li Bo , Zheng Qingyin 
Published: September 2022

Purpose:Congenital deafness not only delays auditory development but also hampers the ability to perceive nonspeech and speech signals. This study aimed to use auditory event-related potentials to explore the mismatch negativity (MMN), P3a, negative wave (Nc), and late discriminative negativity (LDN) components in children with and without hearing loss.Method:Nineteen children with normal hearing (CNH) and 17 children with hearing loss (CHL) participated in this study. Two sets of pure tones (1 kHz vs. 1.1 kHz) and lexical tones (/ba2/ vs. /ba4/) were used to examine the auditory discrimination process.Results:MMN could be elicited by the pure tone and the lexical tone in both groups. The MMN latency elicited by nonspeech and speech was later in CHL than in CNH. Additionally, the MMN latency induced by speech occurred later in the left than in the right hemisphere in CNH, and the MMN amplitude elicited by speech in CHL produced a discriminative deficiency compared with that in CNH. Although the P3a latency and amplitude elicited by nonspeech in CHL and CNH were not significantly different, the Nc amplitude elicited by speech performed much lower in CHL than in CNH. Furthermore, the LDN latency elicited by nonspeech was later in CHL than in CNH, and the LDN amplitude induced by speech showed higher dominance in the right hemisphere in both CNH and CHL.Conclusion:By incorporating nonspeech and speech auditory conditions, we propose using MMN, Nc, and LDN as potential indices to investigate auditory perception, memory, and discrimination.
The Influence of Communication Sample Length on Reliability and Convergent Validity of Vocal Measures Derived From the Communication Complexity Scale
Authors: McDaniel Jena , Brady Nancy C. 
Published: September 2022

Purpose:
This study examines the effects of communication sample length on the reliability and convergent validity of six vocal measures for children with autism spectrum disorder (ASD) with minimal verbal skills. The results are expected to inform recommendations for the length of communication samples for clinical and research purposes.

Method:

Participants included 31 children with ASD (24 boys and seven girls;
M
age
= 6;7 [years;months],
SD
= 17 months) with minimal verbal skills. We coded six vocal measures that focus on vocalizations and early word productions from the Communication Complexity Scale (CCS) scripted administration protocol. To evaluate reliability of different sample lengths, we calculated intraclass correlation coefficients between the full CCS sample and 1-, 3-, 7-, 10-, and 20-min samples. To examine convergent validity, we calculated correlations between the six vocal measures for each sample length.

Results:
When coded from 10-min samples from the beginning of the CCS, all of the vocal measures exhibit adequate reliability with the full CCS sample. Some vocal measures exhibit adequate reliability with samples as short as 3 min. For convergent validity, all of the correlations between the vocal measures exceed .40 and are statistically significant for the 10-min samples except for some of the correlations with the proportion of communicative vocalizations. Similar results were found for other sample lengths.

Conclusion:
Findings support coding 10-min segments from the CCS scripted administration protocol to evaluate the vocal development skills of children with ASD with minimal verbal skills.

Supplemental Material:

https://doi.org/10.23641/asha.20999938
Lebensqualität und Outcome nach Holmiumlaserenukleation der Prostata (HoLEP)
Authors: Kanne Martin , Beutel Holger , Krediet Jorien , Kössler Robert , Kittner Beatrice , Schmuck Nils , Spreu Thomas , Friedersdorff Frank , Maxeiner Andreas 
Published: September 2022

Zusammenfassung
Hintergrund Die Holmium-Laser-Enukleation der Prostata(HoLEP)
wurde vor gut 20 Jahren als wirksame Alternative zur transurethralen Resektion der
Prostata(TURP) eingeführt mit vorteilhafterem Nebenwirkungsprofil. Die HoLEP kann unabhängig
von der Prostatagröße angewendet werden und wird seitens urologischen Leitlinien für die
chirurgische Behandlung der benignen Prostata Hyperplasie (BPH) empfohlen. Dennoch äußern
Patienten gegenüber transurethralen Desobstruktionen oft Misstrauen und Ängste in Bezug auf
Schmerzen und potentielle Komplikationen. Das Ziel dieser Arbeit war es, auf Basis von
„Patient-reported Outcome Measures“ (PROMs) mittels Fragebögen, die Zufriedenheit anhand der
Empfindungen der Patienten zu evaluieren.
Material und Methoden In der Zeit von Juni bis
einschließlich Dezember 2020 wurden 152 Patienten mittels HoLEP aufgrund einer subvesikalen
Obstruktion operiert und mittels Fragebögen unmittelbar postoperativ und 3 Monate später
bezüglich Ihrer Behandlungs-Zufriedenheit und ihrer Miktionsfunktion und Kontinenz befragt. Es
wurden 112 Patienten in die Studie eingeschlossen. Das 3 Monats-Follow-up konnte für 88 dieser
Patienten in die retrospektive Analyse aufgenommen werden.
Ergebnisse Es wurden
durchschnittlich 62,1 [g] Adenomgewebe enukleiert bei einem durchschnittlichen präoperativ
transrekalem Ultraschall(TRUS)-Volumen von 83,1 [cm3]. In 45,4% der Patienten lag bereits
präoperativ ein transurethraler Dauerkatheter ein. Es zeigte sich eine Gesamtzufriedenheit mit
der OP und dem Aufenthalt in der Klinik postoperativ bei 94,6% und nach drei Monaten bei
91,8%. Der Anteil der mit der Miktion zufriedenen Patienten betrug postoperativ 76,5% und
steigerte sich auf 80,4% nach 3 Monaten. Der Anteil der Patienten, die Kontinenzbeschwerden
angaben, lag initial bei 8,3% dann 3 Monate später bei 9,1%. Bei der Frage nach dem
Lebensqualitätsindex [L] verbesserten sich die positiven Antworten von 62,1% postoperativ auf
85,7% nach 3 Monaten. Der Anteil der Patienten mit negativen Antworten reduzierte sich von
11,7% auf 3,4%.
Diskussion Die HoLEP ist ein etabliertes und sicheres Verfahren zur
operativen Therapie der BPH. Um auf die bestehenden Vorbehalte bei Patienten eingehen zu
können, ist eine Befragung der subjektiven Zufriedenheit von operierten Patienten nach dem
Eingriff und im zeitlichen Verlauf wichtig. Die festgestellte hohe Patientenzufriedenheit
könnte sowohl betroffene Patienten als auch niedergelassene Kolleg*Innen motivieren, möglichst
frühzeitig eine operative Intervention zu erwägen.
Spontaneous Rapid Resolution of Acute Subdural Hematoma: Revelation in the Era of Modern Science
Authors: Vemula Ramesh Chandra , Prasad BCM , Banavath Hanuma Naik , Gokanapudi Sreeram , Reddy Kalakoti Chandra Sekhar 
Published: September 2022

AbstractAcute subdural hematoma (SDH) with mass effect and midline shift is an indication for emergency surgery in neurotrauma. A very few case reports were present in the literature showing rapid resolution of acute SDH with improvement in clinical condition of the patient within hours after trauma. In this article, we presented a case of acute SDH that showed almost disappearance of hematoma within 5 hours after trauma.
Outcomes and Predictors of Outcome with Cisternostomy in the Management of Traumatic Brain Injury—A Prospective Observational Study at a Tertiary Centre
Authors: Vemula Ramesh Chandra , Prasad BCM , Banavath Hanuma Naik , Kale Pavan Kumar G , Krishna N Mohana Murali , Gokanapudi Sreeram 
Published: September 2022

Abstract
Background Traumatic brain injury (TBI) is a major cause of morbidity and mortality in young individuals. Goal of management in TBI patients is mainly focused on the secondary injury. Since the cisterns and the brain communicate, it would be possible to decrease the pressure in both these compartments by opening the cisterns to the atmospheric pressure.
Objective To study the outcomes and predictors of outcome with cisternostomy in the management of TBI.
Methods A single tertiary care center's prospective observational study of outcomes with cisternostomy with intraoperative intracranial pressure (ICP) monitoring. Patients were evaluated clinically and radiologically with Marshall CT score. They were categorized into mild, moderate, and severe head injury groups based on Glasgow coma scale (GCS) score. Outcomes were evaluated with Glasgow outcome scale (GOS) score.
Results A total of 25 patients with TBI were enrolled in this study. They underwent cisternostomy with intraoperative ICP monitoring. They were categorized into 4 groups based on the age. In our study, mortality rate was 32%. As much as 48% had good recovery at 3 months follow-up with GOS 4 and 5. Mean ICP after cisternostomy was 6.36 ± 1.91 mm Hg. In our study, there was decrease in ICP after cisternostomy.
Conclusion Age, time interval from trauma to surgery, and ICP showed prognostic importance on outcomes. Cisternostomy can efficiently decrease the ICP in the TBI patients and reduce postoperative complications.
Physical function limitation among gay and bisexual men aged ≥55 years with and without HIV: findings from the Australian Positive and Peers Longevity Evaluation Study (APPLES)
Authors: Boettiger David C. , Huque Md. Hamidul , Bloch Mark , Woolley Ian , Templeton David J. , Law Matthew G. , Fraser Neil , Hoy Jennifer , Petoumenos Kathy 
Published: September 2022

Background As people living with HIV now have a life expectancy approaching that of the general population, clinical care focuses increasingly on the management and prevention of comorbidities and conditions associated with aging. We aimed to assess the prevalence of physical function (PF) limitation among gay and bisexual men (GBM) and determine whether HIV is associated with severe PF limitation in this population. Methods We analysed cross-sectional data from GBM aged ≥55 years in the Australian Positive and Peers Longevity Evaluation Study who completed a self-administered survey on health and lifestyle factors. PF was measured using the Medical Outcomes Study–Physical Functioning scale. Factors associated with severe PF limitation were assessed using logistic regression. Results The survey was completed by 381 men: 186 without HIV and 195 with HIV. Median age was 64.3 years for GBM without HIV and 62.1 years for GBM with HIV. Compared with men without HIV, those with HIV had higher proportions of severe (13.3% vs 8.1%) and moderate-to-severe (26.7% vs 24.2%) PF limitation. Severe PF limitation commonly involved difficulty with vigorous activity (95% with severe PF limitation described being limited a lot), climbing several flights of stairs (68.4% limited a lot), bending, kneeling or stooping (60.5% limited a lot), and walking 1 km (55.0% limited a lot). In a model adjusted for age, body mass index, typical duration of physical activity, psychological distress, and number of comorbidities, we found a significant association between HIV and severe PF limitation (adjusted odds ratio 3.3 vs not having HIV, 95% confidence interval 1.3–8.7). Conclusions The biological mechanisms underlying this association require further investigation, particularly given the growing age of the HIV population and inevitable increase in the burden of PF limitation.
Mixed lineage kinase 3 and CD70 cooperation sensitize trastuzumab-resistant HER2+breast cancer by ceramide-loaded nanoparticles
Authors: Kumar Sandeep , Das Subhasis , Sun Jingjing , Huang Yixian , Singh Sunil Kumar , Srivastava Piush , Sondarva Gautam , Nair Rakesh Sathish , Viswakarma Navin , Ganesh Balaji B. , Duan Lei , Maki Carl G. , Hoskins Kent , Danciu Oana , Rana Basabi , Li Song , Rana Ajay 
Published: September 2022

Trastuzumab is the first-line therapy for human epidermal growth factor receptor 2-positive (HER2+) breast cancer, but often patients develop acquired resistance. Although other agents are in clinical use to treat trastuzumab-resistant (TR) breast cancer; still, the patients develop recurrent metastatic disease. One of the primary mechanisms of acquired resistance is the shedding/loss of the HER2 extracellular domain, where trastuzumab binds. We envisioned any new agent acting downstream of the HER2 should overcome trastuzumab resistance. The mixed lineage kinase 3 (MLK3) activation by trastuzumab is necessary for promoting cell death in HER2+breast cancer. We designed nanoparticles loaded with MLK3 agonist ceramide (PPP-CNP) and tested their efficacy in sensitizing TR cell lines, patient-derived organoids, and patient-derived xenograft (PDX). The PPP-CNP activated MLK3, its downstream JNK kinase activity, and down-regulated AKT pathway signaling in TR cell lines and PDX. The activation of MLK3 and down-regulation of AKT signaling by PPP-CNP induced cell death and inhibited cellular proliferation in TR cells and PDX. The apoptosis in TR cells was dependent on increased CD70 protein expression and caspase-9 and caspase-3 activities by PPP-CNP. The PPP-CNP treatment alike increased the expression of CD70, CD27, cleaved caspase-9, and caspase-3 with a concurrent tumor burden reduction of TR PDX. Moreover, the expressions of CD70 and ceramide levels were lower in TR than sensitive HER2+human breast tumors. Our in vitro and preclinical animal models suggest that activating the MLK3–CD70 axis by the PPP-CNP could sensitize/overcome trastuzumab resistance in HER2+breast cancer.
Exchange Structure: Refinements to the model through a study of multiparty discourse of 4 to 5 year-old children
Authors: Berry Margaret , Mukherjee Sarah Jane 
Published: September 2022

Abstract
This paper proposes a number of refinements to the original theory of Exchange Structure as first conceived. It first offers a summary of the early ideas and considers challenges made by others. The study responds to these challenges through new analysis of multiparty discourse. The paper discusses revisions to the model based on these challenges drawing on the iterative analysis conducted and considers other points relevant to multiparty discourse. The data is drawn from transcribed video recordings of small groups of 4 to 5 year-old children’s peer-led dialogic interactions as they engage in role-play. In addition to the development of Exchange Structure theory, this new analysis sheds light on the nature of negotiation within multiparty discourse and the dynamics of negotiation by young children in this playful context.
The origin and the development of 焉 yān in Old Chinese
Authors: Chang Jung-Im 
Published: September 2022

Abstract
The Old Chinese function word 焉 yān is frequently interpreted as a fusion of [於 (‘at/on/in’) + 此 (near demonstrative pronoun)] in terms of its meaning. Ever since Kennedy (1940a, b; 1953) argued that 焉 is a fusion of [於 + *an (third-person pronoun)], it has been controversial as to exactly which third-person pronoun/demonstrative pronoun *an corresponds to in Old Chinese. There is no third-person pronoun/demonstrative pronoun that is appropriate for this reconstruction.
This paper illustrates how 焉 *Ɂan is a fusion of 於 *Ɂa and *niɁ; *nih or *nɔɁ; *nɔh, which means ‘this’ in Proto-Austroasiatic (PAA). The demonstrative is borrowed into Chinese through language contact in the Early Archaic Chinese period (10th to 6th c. BC). This fusion is plausible in historical and phonological terms, while the grammaticalization path of 焉 also accords with that of [於 + demonstrative].
The grammaticalization path of 焉 is examined by analyzing all occurrences of it in the Bronze Inscriptions (BI), The book of odes (Shījīng 詩經), The book of documents (Shàngshū 尚書), and Zuo’s commentary (Zuǒzhuàn 左傳). Also, the usages of its etymological doublet 爰, which is considered to be a fusion of [于 *wa (‘at/on/in’) + near demonstrative pronoun], are analyzed in order to strengthen the argument.
On the “one+verbal classifier” sequence as a delimitative aspect marker in Taiwanese Southern Min
Authors: Hsieh Miao-Ling , Hsiao Su-Ying 
Published: September 2022

AbstractThis paper studies the “one+verbal classifier” sequencetsi̍t-ēthat appears after an indefinite object complement in Taiwanese Southern Min. We call it the post-complement (PC)tsi̍t-ē. While thetsi̍t-ēsequence can be a durative phrase when it is immediately preceded by a verb, the PCtsi̍t-ēcannot be replaced by the durative phrasetsi̍t-ē-á‘a while’ (tsi̍t-ēplus the diminutive suffixá) or other durative phrases. We show that the PCtsi̍t-ēis a sentence-final particle, not a durative phrase serving as a predicate or complement. Moreover, it marks delimitativity, which means ‘termination in a short time.’ It is the same kind of delimitativity that verb reduplication in Mandarin Chinese expresses despite the fact that the latter targets on the verb and is more selective in terms of the verb types that it can occur with. Moreover, the PCtsi̍t-ēcarries the ‘down-play’ meaning. Syntactically, we suggest that it heads an AspP, which occurs above avP.
Formation and constraints of scalar structure in Taiwanese Southern Min
Authors: Lien Chinfa 
Published: September 2022

AbstractThe paper explores the formation and constraint of an aspect of scalar structure in Taiwanese Southern Min (TSM). The scale structure as we understand it is realized as a relation between the degree adverb and the gradable predicates it selects. The gradable predicate that the degree adverb selects must bear the feature of degree. There are two approaches to compose the degree adverb and the gradable predicates it modifies: (1) the top-down construal and (2) the bottom-up construal. The first approach is simple and straightforward and applicable in most cases. However, there will be difficulties when the immediate modified element is an ambivalent element. A way out of the dilemma is the second approach. We give a unitary account ofu7-headed VP constructions in terms of the bottom-up approach, and if viable, it attains a measure of economy. This study also touches on the parametric variations in TSM vis-à-vis Mandarin in the patterns of degree expressions. Such variations in the degree expressions have some implications in the studies of Sinitic languages as well as language universals.
Lifetime extension of gears and main bearings in wind turbines, scientific calculations and practical implementation
Authors: Bill S , Bill V 
Published: September 2022

Abstract
REWITEC, as a part of Cargill Bioindustrial, is a developer and manufacturer of an innovative particle-based surface treatment phyllosilicate-technology for increasing the reliability and the lifetime of wind turbine gears and bearings. The active particles are compatible to all common oils and greases and use lubricants as a carrier to build through their adsorption a protective and repairing phyllosilicate-based coating on the surface. The modified surface has a significantly lower surface roughness, which ensures a better load distribution, lower local pressure and lower tribological stress. Additionally, due to the special layered material structure the particles can be sheared in the tribological contact, which leads to a reduction in friction. All in all, when applying the products systems can run better with reduced friction, wear, surface roughness and temperature. These effects lead to higher reliability and a longer lifetime and thus to cost savings for operators. We would like to show our new scientific study about the lifetime calculation of a grease-lubricated wind turbine main bearing (1.5 MW) with and without the use of technology. The project is a cooperation between REWITEC and Sentient Science who performs lifetime calculations using digital clone method based on real friction coefficient and surface roughness data. The project includes data generation using MTM test bench, in a wind turbine bearing and subsequent simulation based on this data and bearing geometry. The simulation shows that with REWITEC the probability for a bearing failure significantly decreases which leads to a lifetime extension of up to 17.3 years.
Study of blockage and wakes for an on-shore Wind Farm using SCADA data and CFD simulations
Authors: Castellani F. , Khedr A. , Astolfi D. , Celesti L. , Natili F. , Vedovelli M. 
Published: September 2022

Abstract
The ever-changing energy scenario call for a central role of wind energy exploitation within the renewable energy portfolio; the wind resource nowadays is a very precious means of clean energy production and year by year its degree of reliability and efficiency is pushed towards the optimum. For these reasons two topics are now very important for the improving further the conversion performances: the study of the blockage, as nowadays a lot of machines are planned to be installed in the neighbors of existing ones, and the analysis of wakes, as they represent still the main source of losses and reliability issues. For this reason in the present study, which is an example of collaboration between academia and industry, a deep analysis of wind farm flow, blockage, and wake effects was developed using numerical simulations and real-world operational data from an on-shore windfarm owned by Lucky Wind. Results demonstrate the fundamental role of CFD numerical simulation in understanding and interpreting the complex physics of wakes and the overall importance of blockage effects.
Urban Renewable Energy Communities and Energy Poverty: a proactive approach to energy transition with Sun4All project
Authors: Cumo F. , Maurelli P. , Pennacchia E. , Rosa F. 
Published: September 2022

Abstract
The transition to an environmentally sustainable, low-carbon economy requires fundamental transformations in various sectors such as industry, technology, and especially in society as a whole. Adopting and encouraging community energy are the key policies to facilitate sustainable energy and ecological and social transition. The Sun4All methodology aims at the design, promotion and building of energy communities based on solidarity, to contrast energy poverty and foresee the engagement of vulnerable households that normally have many difficulties in becoming active members of an energy sharing project realising PV plants. The selection of the beneficiaries’ families in the urban context is a process both technical, including socio-territorial GIS-based analysis, and social, activating the participation of grass-root associations, local schools, and facilitators. The strategic role of the municipality is coherent with the SECAP and results in the offers of several public building roofs with PV plants that are the cores of the Sun4all Energy Communities and will ensure the delivery of economic benefits for the vulnerable households, while through workshops, site visits to the plants, and communication activities will increase the citizens’ knowledge. The purpose of this paper is to explore the benefits that go far beyond energy efficiency, which is only the starting point.