bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of post‐treatment longitudinal symptom severity clusters with subsequent survival in oropharyngeal cancer
Authors: Haddad Ghazal , Hueniken Katrina , Xu Maria Christine , Bratman Scott , de Almeida John , Goldstein David , Huang Shao Hui , Hansen Aaron , Hope Andrew , Spreafico Anna , Xu Wei , Liu Geoffrey 
Published: July 2022

AbstractBackgroundPatients with cancer often experience multiple symptoms concurrently. We identified patient clusters based on longitudinal symptom severity trajectories in oropharyngeal cancer (OPC) and evaluated the potential clinical utility of this approach.MethodsA retrospective OPC patient cluster analysis using 6 months of symptom severity data from radiotherapy initiation. The clinico‐demographic characteristics and overall survival of patients were compared between clusters.ResultsWe identified four clusters of patients differing in longitudinal symptom severity. Cluster A (n = 168) included patients with the mildest longitudinal symptoms, cluster B (n = 59) and cluster C (n = 63) were intermediate, and cluster D (n = 30) included patients with the worst symptoms. The clusters differed in their HPV status, ECOG performance status, smoking history, drinking history, treatment modality, and 5‐year survival. These clusters separated symptom severity trajectories more distinctly than individual clinico‐demographic characteristics.ConclusionsEarly symptom severity trajectory clustering revealed distinct patient clusters that were prognostic of overall survival.
A competing risk analysis of adherence to the American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and obesity‐related cancer risk in Hispanic/Latino adults in the NIH‐AARP Diet and Health Study
Authors: Pichardo Margaret S. , Irwin Melinda L. , Esserman Denise , Molina Yamile , Ferrucci Leah M. 
Published: July 2022

AbstractIncidence of obesity‐related cancers (ORCs) is rising among US Hispanic/Latino adults, which may be partly due to inadequate engagement in healthy lifestyle behaviors. Prior research on cancer prevention guideline adherence and cancer risk has not considered competing events that may lead to misinterpreting the magnitude of risk between guideline adherence and cancer incidence. Among Hispanic/Latino adults (N = 9204) in the NIH‐AARP Diet and Health Study, we examined the association between adherence to the 2012 American Cancer Society (ACS) guidelines (high, moderate, low) on nutrition and physical activity for cancer prevention and risk of any first observed ORC using Fine and Gray methods for competing risk analysis. Over a median of 10.5 years of follow‐up, there were 619 first ORCs. The cumulative risk of ORC over a 15‐year period was not significantly different across ACS guideline adherence categories (high cumulative incidence function [CIF]: 2.2%‐5.8%; moderate CIF: 2.2%‐6.6%; low CIF: 2.3%‐6.7%, PGray's log rank = .690). In competing risk analysis, high (compared to low) adherence to the ACS guidelines was associated with reduced probability of ORC (subdistribution hazard [SHR]: 0.76, 95% CI: 0.58‐0.996, P = .047), with evidence of a linear trend for increasing adherence (Ptrend = .039). Our findings were consistent with hypothesized inverse associations between ACS guideline adherence and ORC incidence accounting for competing risks. These findings suggest a need for continued public health efforts focused on promoting engagement in healthy lifestyle behaviors to reduce ORC incidence among US Hispanic/Latino adults.
Sangerbox: A comprehensive, interaction‐friendly clinical bioinformatics analysis platform
Authors: Shen Weitao , Song Ziguang , Zhong Xiao , Huang Mei , Shen Danting , Gao Pingping , Qian Xiaoqian , Wang Mengmeng , He Xiubin , Wang Tonglian , Li Shuang , Song Xiang 
Published: July 2022

AbstractIn recent decades, with the continuous development of high‐throughput sequencing technology, data volume in medical research has increased, at the same time, almost all clinical researchers have their own independent omics data, which provided a better condition for data mining and a deeper understanding of gene functions. However, for these large amounts of data, many common and cutting‐edge effective bioinformatics research methods still cannot be widely used. This has encouraged the establishment of many analytical platforms, a portion of databases or platforms were designed to solve the special analysis needs of users, for instance, MG RAST, IMG/M, Qiita, BIGSdb, and TRAPR were developed for specific omics research, and some databases or servers provide solutions for special problems solutions. Metascape was designed to only provide functional annotations of genes as well as function enrichment analysis; BioNumerics and RidomSeqSphere+ perform multilocus sequence typing; CARD provides only antimicrobial resistance annotations. Additionally, some web services are outdated, and inefficient interaction often fails to meet the needs of researchers, such as our previous versions of the platform. Therefore, the demand to complete massive data processing tasks urgently requires a comprehensive bioinformatics analysis platform. Hence, we have developed a website platform, Sangerbox 3.0 (http://vip.sangerbox.com/), a web‐based tool platform. On a user‐friendly interface that also supports differential analysis, the platform provides interactive customizable analysis tools, including various kinds of correlation analyses, pathway enrichment analysis, weighted correlation network analysis, and other common tools and functions, users only need to upload their own corresponding data into Sangerbox 3.0, select required parameters, submit, and wait for the results after the task has been completed. We have also established a new interactive plotting system that allows users to adjust the parameters in the image; moreover, optimized plotting performance enables users to adjust large‐capacity vector maps on the web site. At the same time, we have integrated GEO, TCGA, ICGC, and other databases and processed data in batches, greatly reducing the difficulty to obtain data and improving the efficiency of bioimformatics study for users. Finally, we also provide users with rich sources of bioinformatics analysis courses, offering a platform for researchers to share and exchange knowledge.
An empirical study of public debt sustainability based on fiscal fatigue and fiscal space in CEMAC countries
Authors: Ekouala Makala Ulrich 
Published: July 2022

AbstractThis paper seeks first to test whether there is evidence of fiscal fatigue in the Central Africa Economic and Monetary Community (CEMAC) countries. On the contrary, we want to investigate the impact of fiscal rules on fiscal space to see if the implementation of fiscal rules enhances fiscal space in the region. The findings show evidence of fiscal fatigue for the Republic of Congo, Equatorial Guinea, and Gabon while Cameroon, the Central African Republic, and Chad exhibit no fiscal fatigue behavior. For our second objective, while analyzing the determinants of fiscal space we found that the two fiscal rules (the balanced budget rule and debt rule) implemented in CEMAC Zone do not improve fiscal space. Therefore, there is a need for the fiscal policy stance to supervise the conduct of fiscal rules in the CEMAC region as fiscal rules themselves do not enhance the available fiscal space. Besides, we suggest CEMAC's fiscal policy authorities to integrate the expenditure rule in their fiscal policy framework to mitigate the government expenditure bias.
Laser‐induced heating of polydimethylsiloxane‐magnetite nanocomposites for hyperthermic inhibition of triple‐negative breast cancer cell proliferation
Authors: Onyekanne Chinyerem E. , Salifu Ali A. , Obayemi John D. , Ani Chukwuemeka J. , Ashouri Choshali Habibeh , Nwazojie Chukwudalu C. , Onwudiwe Killian C. , Oparah Josephine C. , Ezenwafor Theresa C. , Ezeala Chukwudi C. , Odusanya Olushola S. , Rahbar Nima , Soboyejo Winston O. 
Published: July 2022

AbstractThis paper presents the results of an experimental and computational study of the effects of laser‐induced heating provided by magnetite nanocomposite structures that are being developed for the localized hyperthermic treatment of triple‐negative breast cancer. Magnetite nanoparticle‐reinforced polydimethylsiloxane (PDMS) nanocomposites were fabricated with weight percentages of 1%, 5%, and 10% magnetite nanoparticles. The nanocomposites were exposed to incident Near Infrared (NIR) laser beams with well‐controlled powers. The laser‐induced heating is explored in: (i) heating liquid media (deionized water and cell growth media [Leibovitz L15+]) to characterize the photothermal properties of the nanocomposites, (ii) in vitro experiments that explore the effects of localized heating on triple‐negative breast cancer cells, and (iii) experiments in which the laser beams penetrate through chicken tissue to heat up nanocomposite samples embedded at different depths beneath the chicken skin. The resulting plasmonic laser‐induced heating is explained using composite theories and heat transport models. The results show that the laser/nanocomposite interactions decrease the viability of triple‐negative breast cancer cells (MDA‐MB‐231) at temperatures in the hyperthermia domain between 41 and 44°C. Laser irradiation did not cause any observed physical damage to the chicken tissue. The potential in vivo performance of the PDMS nanocomposites was also investigated using computational finite element models of the effects of laser/magnetite nanocomposite interactions on the temperatures and thermal doses experienced by tissues that surround the nanocomposite devices. The implications of the results are then discussed for the development of implantable nanocomposite devices for localized treatment of triple‐negative breast cancer tissue via hyperthermia.
Spinal cord decellularized matrix scaffold loaded with engineered basic fibroblast growth factor‐overexpressed human umbilical cord mesenchymal stromal cells promoted the recovery of spinal cord injury
Authors: He Wenli , Shi Chunying , Yin Jia , Huang Feifei , Yan Wenjing , Deng Jin , Zhang Bing , Wang Bin , Wang Haiping 
Published: July 2022

AbstractSpinal cord injury (SCI) will lead to irreversible damage of sensory and motor function of central nervous system, which seriously affects patient's quality of life. A variety of nerve engineering materials carrying various stem cells and cell growth factors had used to promote the repair of SCI, but they could not mimic the actual matric niche at spinal cord to promote cell proliferation and differentiation. Thus, developing novel biomaterial providing better niche of spinal cord is a new strategy to treat the severe SCI. In this study, we constructed porcine spinal cord decellularized matrix scaffold (SC‐DM) with biocompatibility to load engineered basic fibroblast growth factor‐overexpressing human umbilical cord mesenchymal stromal cells (bFGF‐HUCMSCs) for treating SCI. The continuously released bioactive bFGF factors from grafted bFGF‐HUCMSCs and three‐dimensional niche by SC‐DM promoted the differentiation of endogenous stem cells into neurons with nerve conduction function, leading a markedly motor function recovery of SCI. These results indicated that the functional bFGF‐HUCMSCs/SC‐DM scaffold provided more suitable matric niche for nerve cells, that would be a promising strategy for the clinical application of SCI.
Correlated driving‐and‐dissipation equation for non‐Condon spectroscopy with the Herzberg–Teller vibronic coupling
Authors: Fang Jie , Chen Zi‐Hao , Wang Yao , Xu Rui‐Xue , Yan YiJing 
Published: July 2022

AbstractCorrelated driving‐and‐dissipation equation (CODDE) is an optimized complete second‐order quantum dissipation approach, which is originally concerned with the reduced system dynamics only. However, one can actually extract the hybridized bath dynamics from CODDE with the aid of dissipaton‐equation‐of‐motion theory, a statistical quasi‐particle quantum dissipation formalism. Treated as a one–dissipaton theory, CODDE is successfully extended to deal with the Herzberg–Teller vibronic couplings in dipole–field interactions. Demonstrations will be carried out on the non‐Condon spectroscopies of a model dimer system.
The role of free fatty acid receptor pathways in a selective regulation of TRPA1 and TRPV1 by resolvins in primary sensory neurons
Authors: Pyo Hyun‐jeong , An Xue , Cho Hana 
Published: July 2022

AbstractTransient receptor potential ankyrin 1 and vanilloid 1 (TRPA1 and TRPV1, respectively) channels contribute to inflammatory and neuropathic pain, indicating that their pharmacological inhibition could be a novel strategy for treating painful diseases. However, the mechanisms of TRPA1/V1 channel modulation have been mostly characterized to be upregulation and sensitization via variety of exogenous stimuli, endogenous inflammatory mediators, and metabolites of oxidative stress. Here we used calcium imaging of dorsal root ganglion neurons to identify an inhibitor signaling pathway for TRPA1 and TRPV1 regulated by resolvins (RvD1 and RvE1), which are endogenous anti‐inflammatory lipid mediators. TRPA1 and TRPV1 channel activations were evoked by the TRPA1 agonist allyl isothiocyanate and the TRPV1 agonist capsaicin. Our results show that RvD1‐induced selective inhibition of TRPA1 activity was mediated by free fatty acid receptor 4 (FFAR4)‐protein kinase C (PKC) signaling. Experiments assessing RvE1‐induced TRPV1 inhibition showed that RvE1 actions required both FFAR1 and FFAR4. Combined stimulation of FFAR1/FFAR4 or FFAR1/PKC mimicked TRPV1 inhibition by RvE1, and these effects were blocked by a protein kinase D (PKD) inhibitor, implying that PKD is an effector of the FFAR/PKC signaling axis in RvE1‐induced TRPV1 inhibition. Despite selective inhibition of TRPV1 in the nanomolar range of RvE1, higher concentrations of RvE1 also inhibited TRPA1, possibly through PKC. Collectively, our findings reveal FFAR1 and FFAR4 as key signaling pathways mediating the selective targeting of resolvins to regulate TRPA1 and TRPV1, elucidating endogenous analgesic mechanisms that could be exploited as potential therapeutic targets.
An uncommon case of synchronous gastric and colonic metastases from breast cancer
Authors: Ben Kridis Wala , Lajnef Mayssa , Fki Ameni , Belaid Laila , Khanfir Afef 
Published: July 2022

AbstractInvasive lobular carcinoma is the second‐most‐common subtype of breast cancer. It is characterized by a different metastatic pattern with a propensity to metastasize to pleura, peritoneum, gastrointestinal tract, and ovary. We report a woman with known metastatic disease outside the gastrointestinal tract who had endoscopy and colonoscopy for gastrointestinal symptoms. Extensive metastases were found in the stomach and colon with a diffuse infiltration of signet ring‐like cells at histology and immunohistochemical findings consistent with breast carcinoma. To the best of our knowledge, this is the first report of such a case from Africa.
Examining the help‐seeking intentions of Chinese individuals in the United States
Authors: Yee Terence , Ceballos Peggy 
Published: July 2022

AbstractThe underutilization of mental health services by Chinese individuals in the United States is concerning. In this study, we examined Chinese individuals’ help‐seeking intentions utilizing the theory of planned behavior. Two hundred fifty‐one participants were recruited for this study. The results revealed that help‐seeking attitudes (β = 0.28, p < 0.001), perceived behavioral control (β = 0.21, p < 0.001), and subjective norms (β = 0.13, p < 0.001) were found to be significant predictors of help‐seeking intentions. The implications of the results are discussed.
Ending the COVID‐19 pandemic: We still have a long way to go
Authors: Zeng Guangting , Wang Xia 
Published: July 2022

AbstractSpread of the severe acute respiratory syndrome coronavirus 2 B.1.1.529 (Omicron) variant, which led to increased global hospitalizations for coronavirus disease 2019, generated concern about immune evasion and the duration of protection from vaccines, and undermined humanity's confidence in ending the epidemic. The sudden mutation and origin of Omicron is even more of a mystery. The article highlights the virological characteristics and possible origins of Omicron and the global threats and challenges it poses, as well as strategies to deal with it.
Projecting spatiotemporal changes of precipitation and temperature in Iraq for different shared socioeconomic pathways with selected Coupled Model Intercomparison Project Phase 6
Authors: Salman Saleem A. , Hamed Mohammed Magdy , Shahid Shamsuddin , Ahmed Kamal , Sharafati Ahmad , Asaduzzaman Md. , Ziarh Ghaith Falah , Ismail Tarmizi , Chung ‪Eun‐Sung , Wang Xiao‐Jun , Dewan Ashraf 
Published: July 2022

AbstractChanges in precipitation and temperature have crucial implications in the arid region due to their fragile environment. This study was an attempt to estimate possible spatiotemporal alteration of annual and seasonal precipitation and temperature in Iraq. Statistical downscaling of Coupled Model Intercomparison Project Phase 6 (CMIP6) global climate model (GCM) simulations for different shared socioeconomic pathways (SSP) was utilized. The GCMs were ranked according to their skills in simulating climate research unit (CRU) precipitation and temperature climatology along with their seasonality. Nonlocal model output statistics (MOS) models were implemented using a support vector machine (SVM) for downscaling and projection of selected GCM precipitation and temperature. Results revealed ACCESS‐CM2, BCC‐CSM2‐MR, GISS‐E2‐1‐G and MRI‐ESM2‐0 GCMs are most suitable for Iraq. The spatiotemporal changes in precipitation indicated a substantial decrease to north (up to −7.8%·mm−1) while an increase (around 3.0%) to south for different SSPs. Far future (2060–2099) showed both increase and decrease in precipitation than near future (2020–2059). The precipitation was projected to reduce in winter and increase in summer for all climate zones during both periods. The maximum temperature was projected to increase by 4.5°C to the north and 0.9–2°C to the south. In contrast, the minimum temperature was projected to rise by 1.0–3.5°C to both north and south. Both maximum and minimum temperatures may increase; however, more increases might be in winter and less in summer. The minimum temperature increase will be higher than the maximum temperature in the cold northern region and vice versa. Uncertainty in precipitation and temperature projections was higher for the far‐future period with higher SSPs than for the near‐future period with lower SSPs. The results of this study can guide the development of strategic policies for climate resiliency development in Iraq.
Comparing oncoplastic breast reduction with immediate symmetry surgery to standard breast reduction surgery: Are postoperative complications worse?
Authors: Pawlak Natalie , Karamchandani Manish , Wareham Carly , Gaffney Kerry , Zaccardelli Alessandra , Nardello Salvatore , Persing Sarah , Chatterjee Abhishek , Homsy Christopher 
Published: July 2022

AbstractIntroductionOncoplastic breast reduction mammoplasty (ORM) is an excellent treatment option for women with breast cancer and macromastia undergoing breast conservation therapy. Here, we aim to better understand the risks associated with ORM compared to standard reduction mammoplasty (SRM).MethodsA retrospective chart review was performed of patients undergoing ORM or SRM from 2015 to 2021. Primary outcomes included the occurrence of major or minor postoperative complications in the two groups and delays to adjuvant therapy (>90 days) among the women undergoing ORM.ResultsWomen in the ORM group (n = 198) were significantly older (p < 0.001) with a higher prevalence of smoking (p < 0.001), diabetes mellitus (p < 0.01), and a Charlson comorbidity index ≥ 3 (p < 0.001) compared to women undergoing SRM (n = 177). After controlling for potential confounders, there were no significant between‐group differences in the odds of developing postoperative complications (odds ratio = 0.80, 95% confidence interval: 0.36–1.69). Only 3% (n = 4) of the 150 women undergoing adjuvant radiation or chemotherapy experienced delays related to postoperative complications.ConclusionORM has a similar safety profile as SRM, despite the older age and higher number of comorbidities often seen in patients undergoing ORM, and is a safe option for achieving contralateral symmetry at the time of partial mastectomy without delays to adjuvant therapy.
Breast Ultrasound Volume Sweep Imaging: A New Horizon in Expanding Imaging Access for Breast Cancer Detection
Authors: Marini Thomas J. , Castaneda Benjamin , Iyer Radha , Baran Timothy M. , Nemer Omar , Dozier Ann M. , Parker Kevin J. , Zhao Yu , Serratelli William , Matos Gregory , Ali Shania , Ghobryal Bishoy , Visca Adam , O'Connell Avice 
Published: July 2022

ObjectiveThe majority of people in the world lack basic access to breast diagnostic imaging resulting in delay to diagnosis of breast cancer. In this study, we tested a volume sweep imaging (VSI) ultrasound protocol for evaluation of palpable breast lumps that can be performed by operators after minimal training without prior ultrasound experience as a means to increase accessibility to breast ultrasound.MethodsMedical students without prior ultrasound experience were trained for less than 2 hours on the VSI breast ultrasound protocol. Patients presenting with palpable breast lumps for standard of care ultrasound examination were scanned by a trained medical student with the VSI protocol using a Butterfly iQ handheld ultrasound probe. Video clips of the VSI scan imaging were later interpreted by an attending breast imager. Results of VSI scan interpretation were compared to the same‐day standard of care ultrasound examination.ResultsMedical students scanned 170 palpable lumps with the VSI protocol. There was 97% sensitivity and 100% specificity for a breast mass on VSI corresponding to 97.6% agreement with standard of care (Cohen's κ = 0.95, P < .0001). There was a detection rate of 100% for all cancer presenting as a sonographic mass. High agreement for mass characteristics between VSI and standard of care was observed, including 87% agreement on Breast Imaging‐Reporting and Data System assessments (Cohen's κ = 0.82, P < .0001).ConclusionsBreast ultrasound VSI for palpable lumps offers a promising means to increase access to diagnostic imaging in underserved areas. This approach could decrease delay to diagnosis for breast cancer, potentially improving morbidity and mortality.
The [13C]octanoic acid breath test for gastric emptying quantification: A focus on nutrition and modeling
Authors: von Gerichten Johanna , Elnesr Marwan H. , Prollins Joe E. , De Mel Ishanki A. , Flanagan Alan , Johnston Jonathan D. , Fielding Barbara A. , Short Michael 
Published: July 2022

AbstractGastric emptying (GE) is the process of food being processed by the stomach and delivered to the small intestine where nutrients such as lipids are absorbed into the blood circulation. The combination of an easy and inexpensive method to measure GE such as the CO2 breath test using the stable isotope [13C]octanoic acid with semi‐mechanistic modeling could foster a wider application in nutritional studies to further understand the metabolic response to food. Here, we discuss the use of the [13C]octanoic acid breath test to label the solid phase of a meal, and the factors that influence GE to support mechanistic studies. Furthermore, we give an overview of existing mathematical models for the interpretation of the breath test data and how much nutritional studies could benefit from a physiological based pharmacokinetic model approach.