bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voluntary activation of muscle in humans: does serotonergic neuromodulation matter?
Authors: Kavanagh Justin J. , Taylor Janet L. 
Published: July 2022

AbstractIonotropic inputs to motoneurones have the capacity to depolarise and hyperpolarise the motoneurone, whereas neuromodulatory inputs control the state of excitability of the motoneurone. Intracellular recordings of motoneurones from in vitro and in situ animal preparations have provided extraordinary insight into the mechanisms that underpin how neuromodulators regulate neuronal excitability. However, far fewer studies have attempted to translate the findings from cellular and molecular studies into a human model. In this review, we focus on the role that serotonin (5‐HT) plays in muscle activation in humans. 5‐HT is a potent regulator of neuronal firing rates, which can influence the force that can be generated by muscles during voluntary contractions. We firstly outline structural and functional characteristics of the serotonergic system, and then describe how motoneurone discharge can be facilitated and suppressed depending on the 5‐HT receptor subtype that is activated. We then provide a narrative on how 5‐HT effects can influence voluntary activation during muscle contractions in humans, and detail how 5‐HT may be a mediator of exercise‐induced fatigue that arises from the central nervous system.
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Enhancing the Biofidelity of an Upper Cervical Spine Finite Element Model Within the Physiologic Range of Motion and Its Effect on the Full Ligamentous Neck Model Response
Authors: Hadagali Prasannaah , Cronin Duane S. 
Published: July 2022

Abstract
Contemporary finite element (FE) neck models are developed in a neutral posture; however, evaluation of injury risk for out-of-position impacts requires neck model repositioning to non-neutral postures, with much of the motion occurring in the upper cervical spine (UCS). Current neck models demonstrate a limitation in predicting the intervertebral motions within the UCS within the range of motion, while recent studies have highlighted the importance of including the tissue strains resulting from repositioning FE neck models to predict injury risk. In the current study, the ligamentous cervical spine from a contemporary neck model (GHBMC M50 v4.5) was evaluated in flexion, extension, and axial rotation by applying moments from 0 to 1.5 N·m in 0.5 N·m increments, as reported in experimental studies and corresponding to the physiologic loading of the UCS. Enhancements to the UCS model were identified, including the C0-C1 joint-space and alar ligament orientation. Following geometric enhancements, an analysis was undertaken to determine the UCS ligament laxities, using a sensitivity study followed by an optimization study. The ligament laxities were optimized to UCS-level experimental data from the literature. The mean percent difference between UCS model response and experimental data improved from 55% to 23% with enhancements. The enhanced UCS model was integrated with a ligamentous cervical spine (LS) model and assessed with independent experimental data. The mean percent difference between the LS model and the experimental data improved from 46% to 35% with the integration of the enhanced UCS model.
The Construction of Biologically Relevant Fiber-Reinforced Hydrogel Geometries Using Air-Assisted Dual-Polarity Electrospinning
Authors: Nowak James F. , Kerns Andrew , Patel Priyank , Batzinger Kate , Tong Xing , Samuel Johnson 
Published: July 2022

Abstract
Fiber-reinforced hydrogels are a class of soft composite materials that have seen increased use across a wide variety of biomedical applications. However, existing fabrication techniques for these hydrogels are unable to realize biologically relevant macro/mesoscale geometries. To address this limitation, this paper presents a novel air-assisted, dual-polarity electrospinning printhead that converges high-strength electric fields, with low velocity air flow to remove the collector dependency seen with traditional far-field electrospinning setups. The use of this printhead in conjunction with different configurations of deformable collection templates has resulted in the production of three classes of fiber-reinforced hydrogel prototype geometries, viz., (i) tubular geometries with bifurcations and mesoscale texturing; (ii) hollow, nontubular geometries with single and dual-entrances; and (iii) three-dimensional (3D) printed flat geometries with varying fiber density. All three classes of prototype geometries were mechanically characterized to have properties that were in line with those observed in living soft tissues. With the realization of this printhead, biologically relevant macro/mesoscale geometries can be realized using fiber-reinforced hydrogels to aid a wide array of biomedical applications.
Falkner–Skan Problem for a Stretching or Shrinking Wedge With Nanoparticle Aggregation
Authors: Yaseen Moh , Rawat Sawan Kumar , Kumar Manoj 
Published: July 2022

Abstract
The Falkner–Skan problem for stretching or shrining wedge is generalized for nanoparticle aggregation effects. The model is developed in the presence of the magnetic field, thermal radiation, and suction/injection effects. For the inclusion of nanoparticle aggregation effects, modifications of the Krieger-Dougherty model and Maxwell and Bruggeman models are used to predict effective viscosity and thermal conductivity of titania–ethylene glycol (TiO2/EG) nanofluid, respectively. These models are already tested experimentally in the past and are known to predict the true values for the TiO2/EG nanofluid with aggregated nanoparticles. The system of equations depicting the Falkner–Skan problem for a wedge with nanoparticle aggregation effects is transformed via similarity transformations and solved via the “bvp4c” function, which is accessible by matlab software. The validation of results is done through a comparison of results with published literature and a comparison of present results with the “bvp5c” function and RKF-Shooting Technique. As suggested by the previously published experimental studies, it is observed that the nanoparticle aggregation effects are strong even when the nanoparticle concentration is low. The heat transmission rate of TiO2/EG nanofluid is seen as higher with nanoparticle aggregation effects in comparison to its absence. The streamlines become denser and more intense with the presence of a magnetic field. The results of this study apply to several thermal systems, engineering, and industrial process, which utilize nanofluid for cooling, and heating processes.
Thermal Modeling of Water-in-Tube Type Evacuated Tube Solar Collectors to Predict Outlet Water Temperature: An Experimental Validation
Authors: Singh Pushpendra , Gaur M. K. , Tiwari G. N. , Kumar Anil 
Published: July 2022

Abstract
Thermal model is developed to predict the outlet water temperature with respect to time for water-in-tube type evacuated solar collector connected in series. Developed mathematical expression is validated for the single collector and two collectors connected in series. In each collector, there are 20 evacuated tubes connected to the storage tank. Coefficient of determination (R2), reduced chi-square (χ2), and root mean squared error (RMSE) have been calculated to show the prediction accuracy of the developed model. For single and two collectors connected in series, R2 is 99.73% and 99.90%, χ2 is 0.46 °C and 0.39 °C, and RMSE is 0.70 °C and 0.65 °C, respectively. Predicted value shows good agreement with the experimental value. At a constant mass flowrate, the maximum outlet temperature reaches 53.10 °C and 71.50 °C for single and two collectors in series, respectively. The maximum energy for the single collector is 4.12 kW and 4 kW, while for two collectors connected in series, the maximum energy is 7.08 kW and 6.69 kW. Average thermal efficiency is 4.45% and 4.51% and average exergy efficiency is 9.66% and 15.17% for single and series-connected collectors, respectively. Developed model can design energy-efficient “water-in-tube type evacuated tube collector” for domestic and industrial applications.
A Computational Model to Simulate Thunderstorm Downbursts for Wind Turbine Loads Analysis
Authors: Pratapa Phanisri P. , Nguyen Hieu H. , Manuel Lance 
Published: July 2022

Abstract
The generation of wind fields is of interest in the study of the structural performance of wind turbines in critical events, such as thunderstorm downbursts. Various methods ranging from the use of empirical data to employing computational simulations are typically adopted to study the response of wind turbines in downburst flow fields. While the former approach is limited in the ability to account for accurate and spatially resolved details of the flow field, the latter is expensive and, therefore, has limitations in its use. As an alternative, in this work, we propose a paused downburst model in which a snapshot of a time-dependent computational fluid dynamics (CFD) simulation is used to generate “mean” wind fields during thunderstorm downbursts. The developed model for the mean wind field is validated against recorded downburst data in the literature. The turbulent component of the wind field is generated using computationally inexpensive techniques based on Fourier-based power spectral density functions and coherence functions. In an illustrative example, the combined mean and turbulence wind fields are generated and applied on a utility-scale wind turbine to study structural load characteristics during a downburst event.
Promoting Active Aging Through Sports Participation: A Qualitative Exploration of Serious Leisure Among Older Chinese Adults
Authors: Zhou Wenting , Qiu Yajun , Tian Haibo 
Published: July 2022

China’s population of older individuals reached 264.02 million in 2020, an increase of 5.44% from 2010. This study explores how participation in serious leisure sports, which have enduring benefits for older adults, contributes to active aging. In-depth interviews were conducted with 15 older participants aged 60–78 years who had participated in a leisure sport activity for 1 year or longer. A thematic analysis was conducted, and four themes emerged: body improvements, positive emotions, optimistic life attitudes, and social interactions. Older adults who participate in serious leisure sports are empowered via practice and learning opportunities to engage with their aging bodies, pursue psychological benefits, and jointly maintain leisure groups. The findings of this study contribute to our understanding of the “rights-based” approach to active aging and allow us to identify serious leisure sports as an active way for older adults to improve their quality of life.
Exercise Capacity and Biomarkers Among Children and Adolescents With Sickle Cell Disease
Authors: Silva Lea Barbetta Pereira da , Mercês de Jesus Gilmar , Bessa Junior José de , Silva Valter Abrantes Pereira da , Mattos Ivanilde Guedes de , Jenerette Coretta Melissa , Carvalho Evanilda Souza de Santana 
Published: July 2022

Background: Sickle cell disease is the most common genetic hemoglobinopathy globally and systemically affects body functioning, decreasing exercise capacity. Objective: To assess exercise capacity through the 6-minute walk test (6MWT) and biomarkers in children and adolescents with sickle cell disease. Materials and Methods: Cross-sectional study involving 20 children and adolescents from Brazil. Demographic and socioeconomic data were obtained. Baseline measurements included biomarkers (red blood cells, hemoglobin, hematocrit, white blood cells, platelets, reticulocytes, lactate dehydrogenase, creatine phosphokinase, C-reactive protein, interleukin 6, and fetal hemoglobin). The following data were obtained before, during, and after the 6MWT: heart rate, blood pressure, and peripheral oxygen saturation. Results: Eighteen children and adolescents ages 5–14 years old were analyzed, 61.1% boys, 100% black or brown, and 61.1% in primary education, with low household income. The average distance walked in 6MWT was 463.8 (137.7) m, significantly less than the predicted value (P < .001). The distance of 6MWT was associated positively with age (P = .042) and inversely with reticulocyte count (P = .42) and interleukin 6 (P = .00). Age modified the effect of interleukin 6 in younger children (P = .038). Conclusion: Our findings suggest increased baseline levels of biomarkers of hemolysis and inflammation impact on 6MWT performance.
Clinical diagnosis of seasonal influenza by physicians: a retrospective observational study
Authors: Maita Hiroki , Kobayashi Tadashi , Akimoto Takashi , Matsuoka Fumihiko , Funakoshi Shigeki , Osawa Hiroshi , Kato Hiroyuki 
Published: July 2022

ObjectiveTo elucidate the diagnostic accuracy of pretest probability of influenza (%) by physicians and the factors affecting the clinical diagnosis.DesignRetrospective, single-centre observational study.SettingA community primary care clinic in Japan.ParticipantsThe participants were recruited from a database of studies conducted during the influenza season from December 2017 to April 2019.Primary outcome measureSensitivity and specificity of the physician’s clinical diagnosis of influenza recorded in the medical record as pretest probability.ResultsA total of 335 patients (median age, 31 years; male, 66.6%) were analysed in this study. The area under the curve (AUC) of the physician’s pretest probability was 0.77. At a cut-off value of 30%, the sensitivity and negative likelihood ratio were 92.0% (95% CI 86.7 to 95.7) and 0.19 (95% CI 0.11 to 0.33), respectively. At a cut-off value of 80%, the specificity and positive likelihood ratio were 90.8% (95% CI 85.4 to 94.6) and 4.01 (95% CI 2.41 to 6.66), respectively. The AUCs of patients who had and had not taken any medications before visiting the clinic were 0.77 (95% CI 0.69 to 0.85) and 0.78 (95% CI 0.71 to 0.84), respectively. The AUCs of patients with type A and B influenza were 0.78 (95% CI 0.72 to 0.84) and 0.76 (95% CI 0.70 to 0.82), respectively. The AUCs of vaccinated and unvaccinated patients were 0.80 (95% CI 0.72 to 0.88) and 0.76 (95% CI 0.63 to 0.89), respectively. The AUC for patients less than 12 hours after onset was 0.69 (95% CI 0.51 to 0.88), and that for patients aged younger than 6 years was 0.69 (95% CI 0.49 to 0.88).ConclusionsThe physician’s pretest probability of influenza (%) may be useful for both definitive and exclusionary diagnoses within the limits of our study.
Essential core competencies for scope of practice of paediatric oncology nurses in Latin America: a scoping review protocol
Authors: Lopes-Júnior Luís Carlos , Lima Regina Aparecida Garcia , Maia Edmara Bazoni Soares , Ribeiro Karina de Cássia Braga , Fuentes-Alabí Soad , Sullivan Courtney E , Abraham Monnie , Weber Lorena Segovia , Ponce Liliana Vásquez 
Published: July 2022

IntroductionNurses comprise the largest group of health workers globally and are essential to the provision of care necessary for delivering curative therapy to children with cancer. In high-income countries, previous studies of the nurse workforce have shown an association between patient morbidity and mortality and nursing-related factors such as staffing, education and the nursing practice environment. There is currently limited evidence available to define the scope of essential core competencies for paediatric oncology nursing (PON) practice internationally and specifically in Latin America. Clearly defined essential core competencies contribute to establishing nurses’ scope of practice within clinical practice, education and research settings. Here, we aimed to map and synthesise the available evidence on the scope of PON practices in the context of clinical practice, educational training and research settings in Latin America.MethodsA scoping review (ScR) protocol is reported, adhering to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols statement and guided by The Joanna Briggs Institute. MEDLINE/PubMed, Cochrane Library, Embase, CINAHL, Web of Science, Scopus, Science Direct and Latin American and Caribbean Health Sciences Literature, plus additional sources: The ProQuest Dissertation & Theses Global, The British Library, Google Scholar, medRXiv, ClinicalTrials.gov and WHO-ICTRP will be searched. No date or language restrictions will be employed. Two independent researchers will conduct all the steps of this ScR. The findings will be presented through tables, charts, narrative summaries and assessed based on the outcomes. The search strategy will be updated in May 2022. The expected completion date for this ScR is November 2022.Ethics/disseminationThis protocol does not require ethical approval. The dissemination plans comprise peer-reviewed publication and conference presentations, to be shared with International Oncology Societies/International Nursing Societies and advisory groups to inform discussions on future research. We expect that our results will be of interest to nurse professionals, especially, PON and nurse scholars concerned with this particular issue.
Still poorly adopted in male professional football: but teams that used the Nordic Hamstring Exercise in team training had fewer hamstring injuries – a retrospective survey of 17 teams of the UEFA Elite Club Injury Study during the 2020–2021 season
Authors: Ekstrand Jan , Bengtsson Håkan , Walden Markus , Davison Michael , Hagglund Martin 
Published: July 2022

ObjectivesThe primary objective was to study the adoption of the NHE programme in European football teams in the 2020/21 season and to compare it to the previous study. A second objective was to compare hamstring injury rates between teams that used the NHE programme in the team training and teams that used the NHE only for players with previous or current hamstring injuries.MethodsData about the implementation of the NHE programme and injury rates were included for 17 teams participating in the Elite Club Injury Study during the 2020/2021 season.ResultsOne team (6%) used the full original NHE programme, and another four teams used it for all or most players in the team (team training group, n=5). Eleven teams used NHE only for players with a previous or current hamstring injury (individual training group), and one team did not use NHE. The team training group had fewer hamstring injuries (5 vs 11 per team, p=0.008) and a lower injury burden (12 vs 35 lay-off days per 1000 hours, p=0.003) than the individual training group.ConclusionSimilar to previous reports, low adoption of the NHE programme was seen in the 2020/2021 season. The low adoption rate (13%) relates to the number of teams fully or partly using NHE programmes. Teams that used NHE for the whole team or most players had a lower hamstring injury burden than teams that used NHE only for individual players.
Using meconium to establish prenatal alcohol exposure in the UK: ethical, legal and social considerations
Authors: Arkell Rachel , Lee Ellie 
Published: July 2022

An expanding policy framework aimed at monitoring alcohol consumption during pregnancy has emerged. The primary justification is prevention of harm from what is termed ‘prenatal alcohol exposure’ (PAE), by enabling more extensive diagnosis of the disability labelled fetal alcohol spectrum disorder (FASD). Here we focus on proposals to include biomarkers as a PAE ‘screening tool’, specifically those found in meconium (the first newborn excrement), which are discussed as an ‘objective’ measure of PAE.We ask the overarching question, ‘Can routine screening of meconium to establish PAE be ethically or legally justified’, and we answer, ‘No’. To reach this conclusion, we discuss three areas. First, we consider the reasons why meconium screening should not be deemed ‘typical’ within the scope of accepted screening tools. We argue that given the aim and necessary timing of the screen, it cannot achieve what it promises. Second, we outline why patient autonomy and consent are not properly accounted for and cannot be reconciled with the ‘routinisation’ of the proposed ‘screening’. Last, we outline why the benefit of such a screen is not clear, focusing on the significance of trust in healthcare professionals (HCP) for the best interests of the future child and pregnant woman.While recognising the adverse effects of heavy alcohol consumption during pregnancy, we emphasise the case for robust ethical, legal and social considerations and the central need for trust between HCP and patients in maternity care. We conclude the permissibility of meconium screening has not been proven, and it is not justified.
Percutaneous embolization of sinus pericranii
Authors: Hoffman Haydn , Koutsouras George W , Oh Justin , Suryadevara Neil , Gould Grahame C 
Published: July 2022

Sinus pericranii is a rare vascular anomaly involving a venous sinus that drains into a subgaleal collection of veins through an emissary vein. Data regarding presentation, management, and outcomes are limited to case reports and small case series. There are no technical videos detailing the technique for percutaneous embolization. We present the case of a child with an enlarging, symptomatic accessory type sinus pericranii with connection to the torcula, who underwent percutaneous embolization after unsuccessful transvenous embolization. Embolization was performed with 3.4 cc Onyx-34 under live fluoroscopy and serial control superior sagittal sinus venograms . Significant reduction of flow into the sinus pericranii was achieved and the lesion had nearly completely resolved at the 3-week follow-up. Percutaneous embolization of the sinus pericranii is a reasonable alternative to transvenous embolization, but additional data are needed to determine the optimal treatment. The technical details and practical considerations discussed here may help neurointerventionalists adopt this treatment. The video also includes references 1–4 which are relevant to this topic.Video 1Case presentation and technique for percutaneous embolization of sinus pericranii­
Prenatal Exercise and Cardiovascular Health (PEACH) Study: impact of pregnancy and exercise on rating of perceived exertion during non-weight-bearing exercise
Authors: Brislane Áine , Matenchuk Brittany A. , Skow Rachel J. , Steinback Craig D. , Davenport Margie H. 
Published: July 2022

The purpose of this study was to determine if rating of perceived exertion (RPE) during non-weight-bearing exercise is influenced by gestational age and exercise training. We conducted a randomized controlled trial to examine the influence of gestational age and exercise training (three to four times per week for 25–40 minutes at 50%–70% of heart rate reserve) on RPE during an exhaustive cycling exercise test. We observed no influence of gestational age, or exercise training status on RPE responses to non-weight-bearing exercise during pregnancy. Trial registration number: NCT02948439. Novelty: Gestational age and/or exercise training does not influence rate of perceived exertion during non-weight-bearing exercise.