bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fuzzy Goal Programming approach for solving linear fractional programming problems with fuzzy numbers
Authors: Maiti Indrani , Mandal Tarni , Pramanik Surapati , das sapan kumar , PRASAD RAJEEV 
Published: June 2022

Abstract
The prediction of a real-life problem like in industrial sector or health sector the outcome is impossible or sometimes it is difficult. Due to high information uncertainty and complicated influencing factors of industrial sector, the traditional data-driven prediction approaches can hardly reflect the real changes in practical situation. Fuzzy programming is a powerful prediction reasoning and risk assessment model for uncertain environment. This article mainly explores and applies a modified form of fuzzy programming; namely Fuzzy Linear Fractional Programming Problem (FLFPP) having the coefficients of the objectives and constraints as triangular fuzzy numbers (TFNs). The FLFPP is converted into an equivalent crisp multi-objective linear fractional programming problem (MOLFPP) and solved individually to associate an aspiration level to it. Then by applying fuzzy goal programming (FGP) technique the maximum degree of each membership goal is obtained by minimizing the negative deviational variables. We carry out two industrial application simulations in a hypothetical industrial scenario. Our study shows that the proposed model is practical and applicable to the uncertain practical environment to realize the prediction and the obtained results are compared with that of the existing methods.
Improving the management of chronic pain, opioid use, and opioid use disorder in older adults: study protocol for I-COPE study
Authors: Kagarmanova Ainur , Sparkman Heather , Laiteerapong Neda , Thompson Katherine , Rosul Linda , Lazar Danielle , Staab Erin , Wan Wen , Kass Amanda , Ari Mim 
Published: June 2022

Abstract
Background.
Older adults with chronic pain, opioid use, and opioid use disorder (OUD) present complex management decisions in primary care. Clinical tools are needed to improve care delivery. This study protocol describes the planned implementation and evaluation of I-COPE (Improving Chicago Older Adult Opioid and Pain Management through Patient-centered Clinical Decision Support and Project ECHO®) to improve care for this population.
Methods.
This study uses a pragmatic, expanding cohort stepped-wedge design to assess outcomes. The study will be implemented in 35 clinical sites across metropolitan Chicago for patients aged ≥ 65 with chronic pain, opioid use, or OUD who receive primary care at one of the clinics. I-COPE includes the integration of patient-reported data on symptoms and preferences, clinical decision support tools, and a shared decision-making tool into routine primary care for more effective management of chronic pain, opioid prescribing, and OUD in older adults. Primary care providers will be trained through web-based videos and an optional Project ECHO® course, entitled “Pain Management and OUD in Older Adults.” The RE-AIM framework will be used to assess the I-COPE implementation. Effectiveness outcomes will include increased variety of recommended pain treatments, decreased prescriptions of higher-risk pain treatments, and decreased patient pain scores. All outcomes will be evaluated 6 and 12 months after implementation. PCPs participating in Project ECHO® will be evaluated on changes in knowledge, attitudes, and self-efficacy using pre- and post-course surveys.
Discussion.
This study will provide evidence about the effectiveness of collecting patient-reported data on symptoms and treatment preferences and providing clinical decision support and shared decision-making tools to improve management for older adults with chronic pain, opioid use, and OUD.
Trial registration
: The study is registered at ClinicalTrials.gov under #NCT04878562.
Osseous healing of the CORA-based leveling osteotomy stabilized with a bone plate, cannulated compression screw, and tension band: a descriptive case series in dogs
Authors: Johnson Tiffany A. , Krier Elizabeth M. , Hulse Don A. , Beale Brian S. , Hudson Caleb C. , Old Gary T. , Peycke Laura E. 
Published: June 2022

Abstract
Background
An osteotomy procedure option for stabilization of the CrCL deficient stifle is the Center of Rotation of Angulation (CORA) Based Leveling Osteotomy (CBLO). The CBLO procedure involves a proximal tibial plateau leveling osteotomy based on the magnitude of the CORA. Correction of the CORA magnitude results in the desired postoperative tibial plateau angle (TPA) without secondary translation. If translation is prevented, the amount of bone contact across the osteotomy is maximized. This coupled with the ability to apply compression across the osteotomy with a cannulated compression screw (CCS) and tension band increases the strength of the construct. The objectives of this descriptive case series is to assess osseous bridging of the osteotomy at 35 days following a CBLO stabilized with a bone plate, CCS, and tension band. A second objective is to determine if there is a shift of the postoperative TPA when compared to TPA at final radiographic evaluation.
Results
Forty-seven dogs (49 stifles) met the inclusion criteria. Multiple breeds were represented with a mean age of 6 years and mean body mass of 32kg. All dogs had incompetent partial or complete CrCL tears. There was approximately 50% incidence of medial meniscal pathology with remaining intra-articular structures appearing normal. No intraoperative complications occurred; there were two postoperative complications including a late onset medial meniscal tear and an implant removal due to infection. At a mean time of 35 days (range 25–39 days) postoperatively, osseous bridging of the osteotomy was Grade 4 in 38 stifles (78%) and Grade 3 in 11 stifles (22%). There was no difference between postoperative TPA and final TPA.
Conclusions
Stabilization of a CBLO osteotomy with a bone plate, CSS, and tension band resulted in the majority of dogs (78%) exhibiting Grade 4 healing and the remainder of dogs (22%) showing Grade 3 healing of the osteotomy at a median of 35 days (range 25days to 39 days) postoperatively. Further, there was no TPA shift recognized at final radiographic assessment.
The clinical characteristics of children with agenesis of the corpus callosum
Authors: duan yuanhui , cao jie 
Published: June 2022

Abstract
Objective: To analyze the clinical features of children with agenesis of the corpus callosum in this study due to the lack description at present. Method: This study retrospectively collected the case data of the agenesis of corpus callosum (ACC) hospitalized in Children's Hospital Affiliated to Chongqing Medical University from January 2015 to October 2021. Results :1.Classification and typing characteristics: 1.1 Classification according to the absence of anatomical structure of corpus callosum: total absence of corpus callosum in 7 cases (5.8%); partial absent of corpus callosum in 80 cases (66.7%) ;Corpus callosum was thin in 33 cases (27.5%). 1.2 Classification according to presence of extra-callosal craniocerebral malformations:69 children with isolated ACC (57.5%); complex ACC with 51 cases (42.5%). 1.3 Classification based on extracranial structural malformations: 52 children (43.3%) with non-syndromic ACC. 68 cases (56.7%) with syndromic ACC. 2. Clinical features: 70 cases (58.3%) of Gross Developmental Delay, 50 cases (41.7%) of epilepsy, 44 cases (37.3%) of microcephaly, 41 cases (34.2%) of malnutrition, 20 cases (16.7%) of respiratory failure. Conclusion: Children with agenesis of corpus callosum are often accompanied by abnormalities of other intracranial structures outside the corpus callosum and abnormal structure of extracranial organs. Children with agenesis of the corpus callosum often have neurological diseases, such as gross developmental delay, epilepsy. Secondly, the incidence of malnutrition is also high, especially the severe malnutrition. In addition, some children may also show respiratory failure, so it is necessary to be alert to the possibility of structural abnormalities of the respiratory system. The children with agenesis of the corpus callosum also have a family history of spontaneous abortion in their mothers, patients with neuropsychiatric diseases in their families, and the family history of early death.
Implementation components and factors that influence the provision of tele-audiology services for children and adults - a mixed-methods approach
Authors: Ramkumar Vidya , Shankar Varsha , Kumar Shuba 
Published: June 2022

Abstract

Background
Tele-audiology has accelerated with the rapid advancement in information and communication technology. There is a significant knowledge gap concerning the use of implementation science and factors influencing tele-audiology as a routine or long-term, sustained effort. This mixed-methods study aimed to identify implementation factors that influence the provision of tele-audiology services.
Method
We carried out a mixed-methods study comprising a scoping review and semi-structured interviews (SSI). Articles describing tele-audiology were included based on a set of inclusion and exclusion criteria.
Results
Data was extracted from 32 studies that were mapped to 21 projects in tele-audiology. The broad areas of focus identified in tele-audiology included the provision of hearing screening, diagnostic evaluation, a combination of diagnostic audiological with otorhinolaryngological evaluation, hearing aid fitting and programming, cochlear implant fitting and mapping, aural re/habilitation services and comprehensive audiological services. Provision of diagnostic and therapeutic services were predominantly carried out using synchronous/ real-time telepractice methods. Asynchronous methods were used predominantly for audiometric screening, video-otoscopy and tympanometry. The most commonly used model was the ‘professional-facilitator-patient’ followed by the ‘professional-patient’ model. Barriers to long-term sustainability included insufficient initial financial investment, lack of reimbursement policies, limited internet (speed and bandwidth), and lack of organisational policies and uniform laws. Successful implementation was reported to be aided by having a stable source of funding, a devoted team of professionals and technicians with defined roles and duties, and with methodical planning.
Conclusion
The scoping review, as well as the interviewees, represented tele-audiology implementation efforts in a wide range of countries that include low-middle income and high-income nations. Successful implementation was reported to be aided by having a stable source of funding, a devoted team of professionals and technicians with defined roles and duties, and with methodical planning. Sustained implementation occurred when the need and usefulness of tele-audiology were accepted by public sector policy-makers. However, a more accurate understanding of sustainability can be obtained by the use of implementation science and frameworks to guide tele-audiology services.
A green plasmonic nanosensor based on AuNPs for bacteria detection in urine
Authors: Ángeles-Pascual A. , Breton-Deval L. 
Published: June 2022

Abstract
Today the health problems related to infection by bacteria and virus have increased notably worldwide; for this reason, the demand for reliable and rapid detection methods are necessary. In this work we present a study of colorimetric bacteria in the urine based on 4-mercaptophenylboronic acid (4-MPBA) functionalized with gold nanoparticles (AuNPs) as a green plasmonic nanosensor (GPN) synthesized via novel and simple hand-made Cinnamomum verum extract by green chemistry. Three molar concentrations of AuNPs were synthesized (1, 2 and 3 mM). The structural characterization results by X-ray diffraction (XRD) indicated the presence of AuNPs, chemical and morphological analysis by high-resolution field emission scanning electron microscopy (HR-FESEM) technique indicated the presence of AuNPs and size distribution of 15, 37 and 135.5 nm, respectability, being 1 mM the concentration the one that produces AuNPs with size control and good dispersion and used to determine the bacterial quantification at concentrations of N1 = 60 mg, N2 = 105 mg and N3 = 120 mg of AuNPs. The urine concentrations were analyzed in the absorbed light in the UV region at different bacteria concentrations, been the concentrations of 120 mg that showed best linear relationship between the absorbance at 534 nm and was the ideal to achieve an equilibrium between the free bacteria and the nanoparticles.
Effectiveness of the Unified Barlow Protocol (UP) and neuropsychological treatment in cancer survivors for cognitive impairments: study protocol for a randomized controlled trial
Authors: Garcia-Torres Francisco , Tejero-Perea Adrián , Gómez-Solís Ángel , Castillo-Mayén Rosario , José Jaén-Moreno Maria , Luque-Salas Bárbara , Gálvez-Lara Mario , Sánchez-Raya Araceli , Jablonski Marcin , Rodríguez-Alonso Beatriz , Aranda Enrique 
Published: June 2022

Abstract
Background: Cancer survivors frequently develop cognitive impairment, which negatively affects their quality of life and emotional well-being. This study compares the effectiveness of a well-established treatment (neuropsychological treatment) with the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) to reduce these cognitive deficits and evaluate the effect of both treatments on anxiety-depressive symptoms and the quality of life of cancer survivors.Methods: A three-arm, randomized superiority clinical trial with a pre-post and repeated follow-up measures intergroup design using a 1:1:1 allocation ratio will be performed. One hundred and twenty-three cancer survivors with mild to moderate cognitive impairment will be randomly assigned to one of the study interventions: a cognitive rehabilitation intervention group, an intervention group with UP intervention, or a control group on the waiting list. The primary outcome is to observe a significant improvement in cognitive function in both intervention groups and a significant decrease in emotional impairments in comparison with the waitlist group. Improvements in anxiety, depression and quality of life are also expected as secondary outcomes. These results will be maintained at six months of follow-up.Discussion: The aim of this trial is to test the efficacy of the UP intervention in reducing cognitive deficits in breast cancer survivors. The results of this trial may be useful in reducing the presence of cognitive problems in cancer survivors and improving their emotional state and quality of life.Clinical Trial registration: ClinicalTrials.gov ID: NCT05289258, Registered 12 March 2022, v01.
The potential global distribution of the invasive alien species Melinis minutiflora under current and future climates
Authors: Maciel Josiane Costa , Silva Ricardo Siqueira , Duque Tayna Sousa , Santos Marinalva Martins , Silva Daniel Valadão , Fernandes Bruno Caio Chaves , Chagas Paulo Sérgio Fernandes das , Santos José Barbosa 
Published: June 2022

Abstract
The invasive exotic plant Melinis minutiflora P.Beauv. is a globally invasive species and impacts the economy, biodiversity, and human well-being. The challenges of biological invasion may be intensified by climate change. The increase in temperatures and concentrations of greenhouse gases may favor the introduction, establishment, and expansion potential of this species. Climate change may influence the effective management of invasive species. The objectives of this study were, for the first time, to use CLIMEX software to determine the distribution potential of M. minutiflora in the world under current climatic conditions and global climate change scenarios for the 2030, 2050, 2070 and 2100. Modeling with CLIMEX was used to research the impacts of climate change on the potential global distribution of M. minutiflora. The potential worldwide distribution of M. minutiflora under current climatic conditions is broad, with suitable climatic conditions expanding in tropical and subtropical regions. Future climate scenarios of 2030, 2050, 2070, and 2100 M. minutiflora will grow poleward and upward as the climate warms. Where climate change results in expanding the species global potential range, strategies must be analyzed so that strategic control plans for biological invasion are often considered. Understanding this threat can help formulate effective prevention, introduction, and response measures in regions deemed inadequate.
Electrodiagnosis of Guillain–Barré Syndrome Reflecting Acute Inflammatory Demyelinating Polyneuropathy with Reversible Conduction Failure: A Concept of Nodopathy
Authors: Kim Sooyoung , Lee Eun Kyoung , Sohn Eunhee 
Published: June 2022

Abstract
Reversible conduction failure (RCF) has been documented in acute motor axonal neuropathy (AMAN) and is considered a sign of nodopathy. Several reports of RCF in acute inflammatory demyelinating polyneuropathy (AIDP) have suggested that it could be a manifestation of nodopathy. We conducted this study to determine the frequency of RCF in AMAN and AIDP and to compare the clinical features between the two groups with or without RCF. RCF was observed in 38.9% and 18.5% patients in the AMAN and AIDP groups in our study, respectively. AIDP patients with anti-ganglioside antibodies represented 29.4% of the cohort. The clinical features of AIDP with RCF were more similar to those of AMAN with RCF than to those of typical AIDP. However, there were no significant differences in the frequency of anti-ganglioside antibody status between the groups. AIDP with RCF may be a manifestation of nodopathy. The current dichotomous electrodiagnostic criteria, classifying demyelinating and axonal neuropathy, are insufficient to define nodopathy. Further studies are required to revise the electrodiagnostic criteria for Guillain–Barré syndrome.
Design and Synthesis of Magnetic Immobilized Pineapple Cellulose/EDTA for Removal of Copper(II) and Zinc(II) by Coordination
Authors: Sayahi Hanan , Asadabadi Simin 
Published: June 2022

Abstract
In recent decades, treatment of polluted water has shifted towards the enhancement of environmentally friendly adsorbents. In this regard, a biosorbent originated from pineapple peel cellulose was synthesized and used for the adsorption of Cu2+ and Zn2+. The magnetic (3-aminopropyl)triethoxysilane was designated to immobilize modified cellulose and ethylenediaminetetraacetic acid. The biosorbent was characterized by FE-SEM, TEM, EDX, XRD, FT-IR, BET, VSM and TGA techniques. The influence of pH, temperature and biosorbent dosage on the cation removal was investigated by Central Composite Design. The maximum uptake% was 93.18 and 96.30% for Cu2+ and Zn2+, respectively. Coordination and electrostatic attraction were proposed as the main reasons for the removal of heavy metal cations. The adsorption of Zn2+ was ultrafast and completed within 40 s and it took 420 s for totally removal of Cu2+. External surface biosorption, the intra-particle diffusion and the diffusion through the smaller pores and slits, in sequence, were the dominant steps in the adsorption of each cation. Modified pseudo-n-order and modified Langmuir-Freundlich were the best models to describe kinetics and equilibrium results. The maximum adsorption capacity of biosorbent for Zn2+ was higher than one for Cu2+ (153.9 versus 149.4 mg·g-1). The regenerating of biosorbent was successfully accomplished for five cycles using a solution of EDTA in the presence of ultrasonic waves.
Sex, menopause, and Alzheimer’s risk: a 31P-MR spectroscopy study of brain mitochondrial function in association with 11C-PiB PET amyloid-beta load
Authors: Jett Steven , Dyke Jonathan , Andy Caroline , Schelbaum Eva , Jang Grace , Yepez Camila Boneu , Pahlajani Silky , Díaz Iván , Brinton Roberta Diaz , Mosconi Lisa 
Published: June 2022

Abstract
Increasing evidence implicates sex and endocrine aging effects on brain bioenergetic aging in the greater lifetime risk of Alzheimer’s disease (AD) in women. We conducted 31Phosphorus Magnetic Resonance Spectroscopy (31P-MRS) to assess the impact of sex and menopause on brain high-energy phosphates [adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi)] and membrane phospholipids [phosphomonoesters/phosphodiesters (PME/PDE)] in 216 midlife cognitively normal individuals at risk for AD, 80% female. Ninety-seven participants completed amyloid-beta (Aβ) 11C-PiB PET. Women exhibited higher ATP utilization than men in AD-vulnerable frontal, posterior cingulate, fusiform, medial and lateral temporal regions (p < 0.001). This profile was evident in frontal cortex at the pre-menopausal and peri-menopausal stage and extended to the other regions at the post-menopausal stage (p = 0.001). Results were significant after multi-variable adjustment for age, APOE-4 status, midlife health indicators, history of hysterectomy/oophorectomy, use of menopause hormonal therapy, and total intracranial volume. While associations between ATP/PCr and Aβ load were not significant, individuals with the highest Aβ load were post-menopausal and peri-menopausal women with ATP/PCr ratios in the higher end of the distribution. No differences in Pi/PCr, Pi/ATP or PME/PDE were detected. Outcomes are consistent with dynamic bioenergetic brain adaptations that are associated with female sex and endocrine aging.
A Graph Theory-based Classification of Mild Cognitive Impairment Using Functional Connectivity Analysis on EEG
Authors: Echeverri-Ocampo Isabel , Ardila-López Karen , Molina-Mateo José , Padilla-Buriticá Jorge Ivan , Llamur Ismael , Restrepo Francia , Segura-Giraldo Belarmino , Iglesia-Vaya Maria 
Published: June 2022

Abstract
Understanding how global brain networks are affected in mild cognitive impairment may explain the changes concerning the electrophysiology of the brain. We research functional changes within neuronal networks in frontal, temporal, parietal lobe and central zone using graph theory in visual oddball paradigm. Thirty subjects (19 females; mean age of 70.63 years old, age range 61 to 79 years old, 11 males; mean age of 70.36 years old, and age range 63 to 81 years old) 14 with mild cognitive impairment and 16 health control. Oddball protocol with target and no target stimuli electroencephalography (EEG) signal were analyzed through functional connectivity (FC) along with Change point detection method and a detailed preprocessing in order to detect dynamical changes in the signal, which reflect the non-stationary behavior of a given EEG signal. Linear Discriminant Analysis (LDA), K-Nearest Neighbor (KNN) and Decision Tree (DT) were trained to classify brain activity in Mild Cognitive Impairment (MCI) and Health Control (HC) subjects based on graph measurements and the physiology interpretation of the Mild Cognitive Impairment. The findings show that using a combination of EEG-based model-free functional connectivity measurements and machine learning to categorize cognitive impairment is effective. The research can be expanded upon to study the possibilities of identifying cognitive decline in real-time, dynamic, and complicated real-world circumstances.
Reaction of nitrocefin with two serines of Pseudomonas aeruginosa penicillin-binding-protein 3
Authors: Newman Hector , Bellini Dom , Krajnc Alen , Tumber Anthony , Tod Julie , Lloyd Adrian , Schofield Christopher , Dowson Christopher 
Published: June 2022

Abstract
Despite their clinical importance, the mechanisms by which β-lactams inhibit penicillin-binding-proteins (PBPs) are not fully defined. X-ray crystallographic and mass spectrometric data studies of a Pseudomonas aeruginosa PBP3 active site variant (Tyr409Ala) reveal evidence for the in vitro acylation of P. aeruginosa PBP3 by reaction of nitrocefin with both Ser294 and Ser349. The results reveal a potentially novel binding mode for β-lactams with PBPs and will inform the design of new PBP inhibitors.