bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ageism, An Invisible Social Determinant of Health for Older Syrian Refugees in Lebanon – A Service Providers’ Perspective
Authors: Chahine Maya Abi , Kienzler Hanna 
Published: May 2022

Abstract
Background
Older refugees face particular challenges because their health and social needs are largely overlooked in humanitarian programmes, policies and research. The few studies available have shown that older refugees suffer from a high prevalence of non-communicable diseases, including mental health problems, increased social isolation and poverty, and difficulty accessing health and social services. This article aims to provide further in-depth understanding of how service providers perceive health and social challenges of older Syrian refugees living in Lebanon by focusing on (1) their health and social challenges; (2) the available and lacking services; (3) participation; and (4) policy recommendations to improve services.
Methods
This study is based on a qualitative research approach. Fifteen semi-structured interviews were conducted with health and social workers providing services to older Syrian refugees living in Lebanon. All interviews were digitally recorded, transcribed, coded and analysed using thematic analysis.
Results
Study results clearly show that older refugees face increased marginalisation and neglect, mainly because of ageism. Ageism experienced at aid agency, family and individual levels, impacts negatively on older refugees. They have a sense of social isolation, neglect and feel they are a burden, consequently their social participation decreases, impacting negatively on their physical and mental health as well as their access to social and health care. Linked to experiences of ageism, study participants noted: (1) high prevalence rates of non-communicable diseases and mental health problems; (2) difficulties accessing care, with inadequate services to support the needs of older refugees; and (3) policy recommendations calling for an holistic approach to aid which takes into consideration the specific needs of older refugees as well as their capabilities.
Concluding Remarks
Ageism is a key determinant of health which negatively impacts the physical, mental and social health, and wellbeing of older Syrian refugees. It pushes them to the margins of society where they are left behind by the humanitarian response, policy makers and researchers, as well as their communities and families. To mitigate this situation, this article calls for directly addressing ageism on social, service and policy levels.
Detectionof Fetal Trisomy 8 Mosaicism with Cell-free Fetal DNA in Maternal Plasma
Authors: Hu Junjie , Yan Kai , Jin Pengzhen , Yang Yanmei , Sun Yixi , Dong Minyue 
Published: May 2022

Abstract
Background
Cell-free fetal DNA in the maternal plasma is widely used to identify the aneuploid, including trisomy 21, 18, 13 and sex chromosomes. While for the detection of rare autosomal trisomies, the outcome has not come to a consensus. Here we reported a case of trisomy 8 mosaicism (T8M) which was identified by cffDNA screening.
Methods
Noninvasive prenatal screening (NIPS), fetal karyotyping, single nucleotide polymorphism array (SNP array) and interphase fluorescence in situ hybridization (FISH) analysis were used to characterize etiology in the fetus.
Results
In this study, trisomy 8 was initially identified by cell-free fetal DNA in the maternal plasma. Ultrasound scans and magnetic resonance imaging observed fetal hydronephrosis and irregular spine. Trisomy 8 mosaicism was diagnosed based on the SNP array and amniocentesis results. The couple decided to continue the pregnancy after genetic counseling and a male infant was delivered. Interphase FISH analysis in the uncultured neonatal cord blood cells confirmed trisomy 8 mosaicism, with a percentage of 10%. In the follow up, periodic fever as well as language retardation was observed, indicating a poor prognosis.
Conclusions
Our study provided an insight into the identification of low level rare autosomal trisomy mosaicism with cell-free fetal DNA.
Protective effect of yellow pond turtle (Mauremys mutica) peptides on cartilage in papain-induced knee osteoarthritis rats via mediating the NF-κB/iNOS-COX-2 pathway
Authors: Yan Jia-xing , Li Zuo-an , Feng Lan-jie , Shen Lu-hong , Zhang Jiu-liang 
Published: May 2022

Abstract
Knee osteoarthritis (KOA) is a common chronic joint disorder worldwide. The water extracts of yellow pond turtle (Mauremys mutica) plastron can be used to repair bones and tendons, but the effect and mechanism of yellow pond turtle peptides (YPTP) on KOA is not clarified. This study aimed to explore the corresponding functional effect and anti-inflammatory activity of YPTP on cartilage in rats with papain-induced KOA by network pharmacology and animal experiments. The network pharmacology results showed that the top ten key target genes of YPTP on KOA included TNF, FPR2, APP, AGTR2, AGTR1, STAT3, NFKBIA, BDKRB2, F2, and BIRC2, which were involved in multiple pathways associated with NF-κB signaling. Protein-protein interaction analysis demonstrated that the key targets of YPTP on KOA included COX-2 and iNOS. In addition, YPTP administration (75 and 150 mg/kg) on rats with papain-induced KOA was performed, and knee joint swelling, biomarkers, inflammatory factors, joint microstructure and joint components were assessed. Animal experiment results indicated that YPTP could decrease the expression of COX-2, iNOS and other inflammatory factors in the NF-κB signaling pathway. YPTP could also regulate the expression of MMP-3 and COLLII induced by inflammatory factors, thereby relieving joint pannus, cartilage damage and bone resorption. Our findings indicated that YPTP could inhibit the NF-κB/iNOS-COX-2 pathway and regulate the expression of MMP-3 and COLLII, thereby restricting cartilage degradation and synovial inflammation. This study may provide a theoretical guidance for the selective use of YPTP supplementation on health regulation in the future.
Synergistic Effect of Zn with Ni on ZSM-5 as Propane Aromatization Catalyst: Effect of Temperature and Feed flowrate
Authors: Oseke G. G. , Atta A. Y. , Mukhtar B. , El-Yakubu B. J. , Aderemi B. O. 
Published: May 2022

Abstract
This work shows how propane was catalytically converted to aromatic compounds over Zn-Ni/HZSM-5 to investigate the synergistic role of nickel as zinc stabilizer and promoter in propane aromatization. Co-impregnation method was employed for Zn-Ni/ZSM-5 synthesis fixed 2 wt. % of zinc and 1, 2 and 3 wt. % of nickel. Modified catalysts were fully characterized. Catalysts crystallinity, structure and microporosity were retained from analysis results. Propane aromatization process was conducted at 540 oC, 1200 ml/g-h gas hourly space velocity and atmospheric pressure. The presence of Ni with Zn improved catalytic performance for all Ni loading. Aromatic selectivity and propane conversion were improved with best performance to be Zn-Ni/ZSM-5 with 2 wt. % Zn, 2 wt. % Ni on ZSM-5 averaging 88 and 60 % for twelve hours’ time on stream. Aromatic selectivity on Zn-Ni/ZSM-5 is eight times better than the parent HZSM-5 and one and half times better than the Zn/ZSM-5 catalyst. The electronic interaction of zinc and nickel resulting from equality of oxidation state of +1 and +2 and metal binding energy change synergistically improved the catalytic performance of the bimetallic Zn-Ni/ZSM-5 over the HZSM-5 and Zn/ZSM-5. Flowrate increase from 6 to 35 ml min-1 was found to decrease propane conversion from 80-40 % with increased aromatic selectivity from 55-80 %. Temperature increase from 500-580 oC favours both propane conversion and aromatic selectivity increase from 50-68 and 55-92 % respectively. The metallic interactions from H2-TPR and XPS analysis revealed strong improvement on propane conversion, aromatic selectivity and product distribution.
The Vienna Idiopathic Intracranial Hypertension (VIIH) database – an Austrian registry
Authors: Pruckner Philip , Mitsch Christoph , Macher Stefan , Krajnc Nik , Marik Wolfgang , Novak Klaus , Wöber Christian , Pemp Berthold , Bsteh Gabriel 
Published: May 2022

Abstract
Background: Idiopathic intracranial hypertension (IIH) is an increasingly prevalent disease bearing the risk of visual impairment and affecting quality of life. Clinical presentation and outcome are heterogeneous. Large, well-characterized cohorts are scarce.Here, we describe the Vienna-Idiopathic-Intracranial-Hypertension (VIIH) database aiming to characterize the clinical spectrum, diagnostic findings, therapeutic management, and outcome of IIH.Methods: We identified patients with IIH according to the modified Dandy criteria who were treated at our center between 2014 and 2021. Methodology and structure of the VIIH database are described in detail including demographics, clinical parameters, magnetic resonance imaging, optical coherence tomography, transorbital sonography, treatment, and outcome.Results: Of 113 patients, 89% were female (mean age 32.3 years). Median body mass index (BMI) was 31.8, with 85% overweight (BMI>25). Papilledema was found in 95% with 5% classified as IIH without papilledema. Headache was present in 84% and showed migrainous features in 43%. Median opening pressure in lumbar puncture was 31cmH2O.Pharmacotherapy (predominantly acetazolamide) was established in 99%, 56% required at least one therapeutic lumbar puncture and 13% surgical intervention. After a median follow-up of 3.7 years, 43% had not achieved significant weight loss, papilledema was present in 59% and headache in 76% (58% improved). Comparing initial presentation to follow-up, perimetry was abnormal in 67% vs. 50% (8% worsened, 24% improved) and transorbital sonography in 87% vs. 65% with a median optic nerve sheath diameter of 5.4mm vs. 4.9mm. Median peripapillary retinal nerve fiber layer thickness had decreased from 199µm to 99µm and ganglion cell layer volume from 1.13mm3 to 1.05mm3.Conclusions: The VIIH database constitutes a large representative cohort, characterizing IIH-related symptoms, diagnostic findings, treatment, and outcome parameters and emphasizing substantial long-term sequelae of IIH. Future analyses will aim to refine phenotyping and identify factors predicting outcome.
What added value of CNRM-AROME convection-permitting regional climate model compared to CNRM-ALADIN regional climate model for urban climate studies ? Evaluation over Paris area (France)
Authors: Lemonsu Aude , Caillaud Cécile , Alias Antoinette , Riette Sébastien , Seity Yann , Roy Benjamin Le , Michau Yohanna , Lucas-Picher Philippe 
Published: May 2022

Abstract
The convection-permitting regional climate model CNRM-AROME was applied on a spatial domain restricted to the northern half of France for analyzing its performances in simulating the urban climate of Paris region, and its potential added value compared to the regional climate model CNRM-ALADIN. In addition to its fine horizontal resolution (2.5 km compared to 12.5 km for CNRM-ALADIN), CNRM-AROME has the advantage of integrating the urban canopy model TEB into its land-surface modelling system. A hindcast simulation was performed for the past period 2000-2017, following an evaluation configuration for which CNRM-AROME was driven by CNRM-ALADIN, driven itself by the ERA-Interim reanalyses. Long-term gridded observations with kilometric resolution allowed a fine spatial scale evaluation of the atmospheric variables simulated by both models. They showed in particular a significant overestimation of spring precipitation, but an improvement of summer precipitation in CNRM-AROME compared to CNRM-ALADIN. Above all, thanks to its horizontal resolution and the use of a dedicated urban model, CNRM-AROME was shown to offer significant added value for the simulation of urban heat islands, for the mapping of heat-warming areas, and for representing the effects of the city on precipitation. It is a promising tool to diagnose climatic and impact indicators at the city scale, and their evolution in a changing climate.
Relation between derived cardiovascular indices, body surface area, blood pressure/heart rate recovery among active and inactive Nigerian student
Authors: Ewah Patrick Ayi , Oyeyemi Adetoyeje Y 
Published: May 2022

Abstract
BACKGROUNDThe ease in the computation of derived cardiovascular indices such as mean arterial pressure [MAP], rate pressure product [RPP] and pulse pressure [PP]), make them attractive for use in making clinical decision for patient management in resource deprived environment. This study sought to determine the relationship between these indices and heart rate/blood pressure drops during recovery state among physically active and inactive individuals following submaximal exercise. RESULTSThis quasi-experimental study conveniently sampled 105 apparently healthy male subjects age 18-35 years of the University of Maiduguri. Inter-group categorization was executed by IPAQ. The derived indices were calculated using heart rate and blood pressure measurement while the body surface area (BSA) was determined using height and weight. The subjects were subjected to a submaximal exercise test using a bicycle ergometer. Data analysis include; descriptive statistic, Pearson correlation, student t-test, analysis of covariance and multiple linear regression. The data was analyse using SPSS version 25.0 at significance of p<0.05. The mean BSA and resting-PP, MAP and RPP were 1.84±0.16 m2, 41.23±7.57 mmHg, 85.92±9 mmHg and 8266.45±1404.05 respectively. The resting-RPP of the physically inactive subjects was significantly higher than that of the active (8742.71±1496.31 vs 7790.18±1131.59, p=0.00) however, the active subject had a higher resting-MAP than the inactive (87.91±7.98 Vs 83.93±9.59, p=0.03). The relationship between the RPP and the Absolute/percent recovery HR was r=-0.23, p=0.02/r=-0.34, p=0.00. The relationship between the PP and absolute recovery SBP was r=0.22, p= 0.03. The relationship found between the MAP and absolute recovery SBP was (r= 0.33, p= 0.00). The best negative predictor negative predictor recovery HR was the RPP while the MAP was the best positive predictor of recovery HR and SBP. CONCLUSIONSOverall, the physically active subjects coped better during the exercise than their inactive counterpart because of lower cardiac work and better blood perfusion to vital body organs. An inverse relationship was found between the RPP and absolute/percent recovery HR at one-minute post exercise while a positive relationship was found between the PP and absolute drop in SBP/percent drop in DBP one-minute post exercise. The best predictor of recovery HR and blood pressure was the RPP.
Self-perceived general health at start of TNFi therapy predicts therapeutic response in patients with rheumatoid arthritis: analysis from the ATTRA registry
Authors: Nekvindová Lucie , Vencovský Jiří , Pavelka Karel , Horák Pavel , Rouhová Renata , Závada Jakub 
Published: May 2022

Abstract
Background: Patient-reported outcomes (PROs) have been shown to predict various disease outcomes. One of the most widely used PRO instruments is the Short Form (SF) 36 questionnaire which evaluates the patient's health status. Our goal was to evaluate the association between therapeutic response and patients' self-perceived general health status at TNFi initiation based on answers to two selected questions (Qs) in the SF-36 questionnaire.Methods: We included two separate datasets with RA patients (pts) initiating the first-line TNFi within the period 01/01/2001–31/12/2017 (primary dataset) and 01/01/2018–01/01/2020 (validation dataset) with at least one‑year follow‑up and filled SF-36 questionnaire at baseline. Patients were grouped according to their response ('definitely/mostly yes' vs 'definitely/mostly no') to Q11A and Q11C at baseline. The primary outcome was remission (REM) according to DAS28-ESR (<2.6) at the 12‑month visit. REM rates were compared across patients' groups with Pearson's chi-squared test. Using logistic regression, crude and adjusted (to baseline DAS28-ESR and HAQ) odds ratios (ORs) were computed. Drug retentions were obtained through the Kaplan-Meier method. We repeated the analysis on propensity score-matched patients at baseline as a sensitivity analysis. Results: Within the primary dataset (648/792 pts answering positively/negatively to Q11A; 730/580 pts answering positively/negatively to Q11C), patients answering 'yes' to Q11A/Q11C had 1.5/1.4 times higher odds for REM at 12-month visit than patients answering 'no'. The odds remained significantly different even after accounting for baseline DAS28-ESR and HAQ and within propensity score-matched datasets. Further, patients answering 'yes' to Q11A had a 1.3 times higher risk of TNFi discontinuation than patients answering 'no'. The validation dataset analysis (216/254 pts answering 'yes'/'no' to Q11A; 231/201 answering 'yes'/'no' to Q11C) gave similar results. Patients answering 'yes' to Q11A/Q11C had 1.7 times higher odds of reaching REM at the 12-month visit than patients responding 'no'. Even after accounting for baseline disease activity and functional status and within PS-matched datasets, the odds remained significantly higher. However, there was no statistically significant difference in drug retentions.Conclusions: We provide strong evidence that self-perceived general health at TNFi initiation predicts reaching remission at 12 months in pts with RA.
Calcium and strontium contractile activation properties of single skinned skeletal muscle fibres from elderly women 66-90 years of age
Authors: Ronaldson Susan M. , Stephenson D. George , Head Stewart I. 
Published: May 2022

Abstract
The single skinned muscle fibre technique was used to investigate Ca2+-and Sr2+-activation properties of skeletal muscle fibres from elderly women (66-90 years). Muscle biopsies were obtained from the vastus lateralis muscle. Three populations of muscle fibres were identified according to their specific Sr2+-activation properties: slow-twitch (type I), fast-twitch (type II) and hybrid (type I/II) fibres. All three fibre types were sampled from the biopsies of 66 to 72 years old women, but the muscle biopsies of women older than 80 years yielded only slow-twitch (type I) fibres. The proportion of hybrid fibres in the vastus lateralis muscle of women of circa 70 years of age (24%) was several-fold greater than in the same muscle of adults (<10%), suggesting that muscle remodelling occurs around this age. There were no differences between the Ca2+-and Sr2+ -activation properties of slow-twitch fibres from the two groups of elderly women, but there were differences compared with muscle fibres from adults with respect to sensitivity to Ca2+, steepness of the activation curves, and characteristics of the fibre-type dependent phenomenon of spontaneous force oscillations occurring at submaximal levels of activation. The maximal Ca2+ activated specific force from all the fibres collected from the seven old women use in the present study was significantly lower by 20% than in the same muscle of adults. Taken together these results show there are qualitative and quantitative changes in the activation properties of the contractile apparatus of muscle fibres from the vastus lateralis muscle of women with advancing age, and that these changes need to be considered when explaining observed changes in women’s mobility with aging.
A phenomic approach of bamboo species identification using deep learning
Authors: Wang Ziwei , Li Jing , Yue Xianghua , Yi Wukun , Wang Hankun , Chen Hong , Tian Genlin 
Published: May 2022

Abstract
Plant has high similarity and dense detail information in morphology, color and texture, especially in bamboo species, which consists of ground tissue and vascular bundles, the cross-sectional images of bamboo belong to fine-grained, for this reason, the classification of bamboo species has always required aid from a domain expert. Recently, deep learning and convolutional neural network (CNN) have become a new solution for image recognition and classification, features can be effectively extracted from bamboo images and high accuracy can be outputted. Here, convolutional neural network models were constructed to achieve the rapid classification of bamboo species, meanwhile, to simulate the complex classification of bamboo, identification complexity was artificially added by mixing all images, but the models were still found feasible. These models are trained to identify 45 bamboo types with Top-1 accuracy of 92.14% and Top-5 accuracy of 98.10%, indicating that the models extracted the specific features from the cross-section images efficiently.
SINR-based Slot Reuse Algorithm for Multi-Channel Wireless Sensor Networks
Authors: Zeng Bo , Liang Zhiqing , Gao Xiaofeng 
Published: May 2022

Abstract
Multi-channel technology can eff ectively eliminate wireless interference. The algorithms proposed for multi-channel sensor networks usually assume that there are enough channels available to enable interference-free parallel transmission. However, in practice, the channels that can be used are limited. This makes it possible that wireless interference cannot be completely eliminated, making parallel transmission impossible. Therefore, it is a challenging problem to develop a scheduling algorithm with fully parallel transmission capability under limited channels. To solve this problem, this paper proposes a heuristic slot reuse algorithm combining Signal to Interference plus Noise Ratio (SINR) and multi-channel technology. The algorithm allocates consecutive slots to nodes in a top-down manner. When the slot cannot be allocated because the SINR is not satisfi ed, a new channel will be added and allocate the slot. The simulation results show that our algorithm achieves concurrent transmission under limited channels, resulting in an optimized scheduling length.
Effect of Electronic Medical Record Management Systems on the Disease Activity and Frequency of Outpatient Visits of Patients with Ankylosing Spondylitis: A cross-sectional
Authors: Huang Pei-Ju , Liu Yen-Tze , Chen Yi-Hsing , Chen Yi-Ming , Lai Kuo-Lung , Hsieh Tsu-Yi , Hung Wei-Ting , Lin Ching-Tsai , Tseng Chih-Wei , Tang Kuo-Tung , Chou Yin-Yi , Wu Yi-Da , Hsieh Chia-Wei , Chen Yen-Ju , Liao Yu-Wan , Chen Hsin-Hua , Huang Wen-Nan , Huang Chin-Yin 
Published: May 2022

Abstract
BackgroundTo investigate the impact of an electronic medical record management system (EMRMS) on disease activity and the frequency of outpatient visits among patients with ankylosing spondylitis (AS).MethodsWe identified 652 patients with AS who were followed up for at least 1 year before and after the first Ankylosing Spondylitis Disease Activity Score (ASDAS) assessment and compared the number of outpatient visits and average visit time within 1 year before and after the initial ASDAS assessment. Finally, we analyzed 201 patients with AS who had complete data and received ≥3 continuous ASDAS assessments at an interval of 3 months, and we compared the results of the second and third ASDAS assessments with those of the first.ResultsThe number of annual outpatient visits increased after ASDAS assessment (5.8 ± 3.4 vs. 5.4 ± 3.4, p < 0.001), particularly among those with a high initial disease activity. The average visit time was reduced within 1 year after ASDAS assessment (8.7 ± 3.8 vs. 9.2 ± 4.4 min, p = 0.030), especially among patients whose ASDAS-C-reactive protein (CRP) was <1.3 (8.5 ± 3.3 vs. 9.2 ± 4.2 min, p = 0.022). Among patients who received at least three ASDAS assessments, the third ASDAS-CRP was significantly lower than the first (1.5 ± 0.8 vs. 1.6 ± 0.8, p = 0.049).ConclusionThe use of an EMRMS increased the frequency of ambulatory visits among AS patients with high disease activity and reduced the visit time among those with an inactive disease. Continual ASDAS assessments may help control the disease activity of patients with AS.Trial registrationInstitutional Review Board (IRB) of Taichung Veterans General Hospital (TCVGH-IRB No.: CE20145B)