bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual Quality of Life in Subjective Tinnitus Individuals With Normal Hearing: A Case–Control Study
Authors: Asta Beyza , Öztürk Özdeş Nazife , Aydoğan Zehra , Uzdil Nurcan , Anadolu Rauf Yücel , Tokgöz Yılmaz Suna 
Published: February 2025

ABSTRACTIntroductionThis study aimed to assess the quality of sexual life among individuals experiencing subjective tinnitus and to draw comparisons with a control group.MethodsThe study included a group of 21 patients with subjective tinnitus as a case group and 21 healthy individuals as a control group. We used patient information form, Arizona Sexual Experiences Scale (ASEX), Sexual Quality of Life Scale–Female (SQOL‐F), Sexual Quality of Life Scale–Male (SQOL‐M), and Tinnitus Handicap Inventory (THI) as the data collection tool in this research.ResultsThe analysis showed no significant difference in average ASEX scores among the groups. It was determined that the SQOL‐F and SQOL‐M score averages were higher in the control group than the case group (p < 0.05). A statistically significant inverse correlation was observed between the THI score and the SQOL‐M score among individuals experiencing subjective tinnitus in the case group. A statistically significant effect of tinnitus discomfort obtained by THI was found on sexual quality of life in men. In individuals with tinnitus, 43% of the SQOL‐M scores evaluating the quality of sexual life in men can be explained by THI.ConclusionFirst of all the sexual quality of life scores of case group was worse than healthy individuals. In addition, the negative correlation between THI and sexual quality of life in male indicates that male individuals are more affected. The sexual quality of life in individuals with tinnitus should be specifically addressed by health professionals.
Dapagliflozin Improves High‐Fat Diet‐Induced Cognitive Impairment in Female Mice
Authors: Chen Xiaolin , Fan Mingxia , Xiao Zhuoni , Xiong Xiaoxing 
Published: February 2025

ABSTRACTBackgroundHigh fat consumption is a known risk factor for the development of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). Sodium‐glucose cotransporter 2 inhibitors (SGLT2is) have been found to possess anti‐inflammatory and neuroprotective properties. However, the cognitive effects and mechanisms of SGLT2is on female mice fed with a high‐fat diet remain unknown.ObjectiveThis study aimed to investigate the impacts of dapagliflozin on metabolism, cognition, neuroinflammation, insulin resistance, and microglial activation in female mice fed a HFD.MethodsDapagliflozin (1 mg/kg) was administered to HFD‐fed mice for 24 weeks. Body weight, glucose tolerance, and insulin resistance were assessed. Additionally, all mice were subjected to the Morris water maze (MWM) and one‐trial Y‐maze tests. The levels of metabolic hormones and cytokines were analyzed using ELISA kits. The levels of phosphorylated tau (p‐tau) protein in the hippocampus were measured. Microglia, insulin receptors, NLRP3, and IL‐1β in the hippocampus of mice were evaluated by immunofluorescence or immunohistochemical staining.ResultsAs anticipated, dapagliflozin improved insulin resistance and glucose metabolism and reduced cognitive impairment in female mice fed with a HFD. In the hippocampus, dapagliflozin alleviated microglial activation yet did not reduce the secretion of inflammatory chemokines. Furthermore, it increased the expression of insulin receptor in the hippocampus of HFD‐fed mice and decreased the expression of p‐tau.ConclusionsOur results provide a foundation for the clinical application of SGLT2is as an adjuvant to slow down the progression of central degenerative diseases related to metabolic disorders, such as AD.
Artificial Intelligence and Breast Cancer Management: From Data to the Clinic
Authors: Feng Kaixiang , Yi Zongbi , Xu Binghe 
Published: February 2025

AbstractBreast cancer (BC) remains a significant threat to women's health worldwide. The oncology field had an exponential growth in the abundance of medical images, clinical information, and genomic data. With its continuous advancement and refinement, artificial intelligence (AI) has demonstrated exceptional capabilities in processing intricate multidimensional BC‐related data. AI has proven advantageous in various facets of BC management, encompassing efficient screening and diagnosis, precise prognosis assessment, and personalized treatment planning. However, the implementation of AI into precision medicine and clinical practice presents ongoing challenges that necessitate enhanced regulation, transparency, fairness, and integration of multiple clinical pathways. In this review, we provide a comprehensive overview of the current research related to AI in BC, highlighting its extensive applications throughout the whole BC cycle management and its potential for innovative impact. Furthermore, this article emphasizes the significance of constructing patient‐oriented AI algorithms. Additionally, we explore the opportunities and potential research directions within this burgeoning field.
Efficient Synthesis, Anticancer Evaluation of Triazole‐Thiadiazole/Benzo[d]oxazole Scaffolds and Investigation of Their Reactivity Properties Using DFT Calculations and In silico Docking
Authors: Avuthu Vidya Sagar Reddy , Allaka Tejeswara Rao , Kushwaha Naveen , vvn kishorepilli 
Published: February 2025

The present study describes a benzo[d]oxazole‐functionalized conventional synthesis of novel [1,2,4]triazolo[3,4‐b][1,3,4]thiadiazine and [1,2,4]triazolo[3,4‐b][1,3,4]thiadiazoles are formed by the condensation of 5 with bromo‐substituted acetophenones and isothiocyanates. The structural elucidation of the newly synthesized compounds was accomplished using various spectroscopic techniques, viz. FT‐IR, NMR (1H/13C) and HRMS spectrometry. As the most prominent one, compound 6c showed the highest anticancer activity against the MDA‐MB‐231 cell line and an IC50 value of 3.01 ± 0.45 µM, which was close to that of the positive control Doxorubicin (IC50 value of 3.10 ± 0.27 µM). It was also observed that compound 8e (IC50 = 3.92 ± 0.04 μM) exhibited superior activity against the T47D cell line, whereas compound 6f (IC50 = 2.10 ± 0.21 μM) demonstrated better activity against the MCF‐7 cell line. In silico docking investigations of the representative ligands further explored the characteristic binding orientations on conserved interactions with residues like LysA:55, ValA:60, ThrA:11, GluA:14, ProA:57, AlaA:15, SerA:51, and GlyA:58 from 1U9E. The tested compounds’ structure‐activity relationships are in good agreement with molecular docking and DFT studies, which demonstrate that the primary cause of the high anticancer activity of 1,2,4‐triazole hybrids is the presence of a lipophilic and heterocyclic substituent on the benzo[d]oxazole component.
Association of Self‐Rated Attribution of Blame for Criminal Acts and of Psychiatric Symptoms Among Patients Undergoing Specialist Forensic Psychiatric Treatment in Japan
Authors: Arakawa Ikuko , Kuroki Noriomi , Takahashi Hidehiko , Okada Takayuki 
Published: February 2025

ABSTRACTBackgroundTreatment goals for offenders with mental disorders include restoring and maintaining health, establishing social participation and preventing negative outcomes, including further offending. The development of patient insight into their prior offences may facilitate their reintegration into society and prevent further harms.AimsTo find out whether, among offenders with mental disorder, their own causal attribution of their criminal acts, based on the Japanese version of the Gudjonsson blame attribution inventory‐revised (GBAI‐R‐J), is associated with psychiatric symptoms according to the positive and negative syndrome scale (PANSS) ratings.MethodsA cross‐sectional study was conducted by collecting data from 45 patients in forensic psychiatric services, both in‐ and out‐patients. All participants had a psychosis and a history of serious crimes. Attribution of blame was self‐rated in the same session during which a clinician rated their symptoms using the PANSS. GBAI‐R‐J scores were converted into a categorical variable by allocating each participant into one of two groups—those scoring up to the half point or those scoring at or above it on each subscale. The three PANSS scale scores were treated as continuous variables.ResultsThere was a significant positive relationship between the GBAI‐R‐J externalising blame scores and PANSS scores for positive symptoms and general psychopathology but not for negative symptoms. Neither the acceptance of personal the guilt factor nor the mental element factor, which imply attribution of the offence to mental disorder, was significantly related to any aspect of symptoms.ConclusionsThis is the first study to compare blame attribution for a serious index offence and mental state simultaneously, albeit at various stages of treatment and time after the offence. The association of persistent positive symptoms with externalising blame is understandable in terms of the nature of the symptoms, almost invariable including paranoid delusions. The absence of a relationship with acceptance of guilt or understanding the role of mental disorder in the offending suggests that many of these patients require further treatment to accept personal agency. A longitudinal study is indicated to test these possibilities further.
Navigating a Rare Neurological Conundrum: Quadriparesis in Neurocysticercosis With Hydrocephalus
Authors: Krishna Mudamanchu Vamsi , Biswas Pubali , Jayashankar C. A. , Ganaraja V. H. , Joshi Amey 
Published: February 2025

ABSTRACTThis case illustrates the diagnostic challenges in identifying neurocysticercosis, which is initially mistaken for tubercular arachnoiditis. Early recognition and multidisciplinary management are crucial for preventing severe complications. The case also describes the importance of awareness and timely treatment of neglected tropical diseases to improve patient outcomes.
Post‐COVID‐19 Neutropenia in an Infant With Thalassemia Minor: Case Report
Authors: Elsherif Yasmine , Elsherif Omar , Karimi Mehran , Ibrahim Ismail A. , Abukhadijah Hana J. 
Published: February 2025

ABSTRACTThis case of an 11‐month‐old female who developed severe neutropenia following COVID‐19 infection underscores the need for heightened vigilance and monitoring of hematological parameters in infants post‐COVID‐19. The exact mechanism of COVID‐19‐induced neutropenia is not fully understood, but it may involve cytokine‐induced suppression of hematopoiesis and bone marrow repression due to the inflammatory response. Given the potential for serious clinical implications, including increased susceptibility to infections, it is crucial to effectively identify and manage neutropenia in this vulnerable population. Further research is necessary to elucidate the underlying mechanisms and optimize treatment strategies for COVID‐19‐related hematological complications in infants.
Navigating the Future: Factors Influencing Adolescents' Career Expectation Uncertainty in a Dynamic World
Authors: Guo Luyang 
Published: February 2025

ABSTRACTIn an era of rapid economic, technological, and social change, young people face increased challenges in making informed career decisions. This study, grounded in Social Cognitive Career Theory (SCCT) and Career Construction Theory (CCT), examines the personal and environmental factors influencing career expectation uncertainty among 15‐year‐olds across 78 educational systems. Results of multilevel logistic models revealed that approximately 20% of adolescents, particularly young men and those in advanced economies, experienced more uncertainty about their career expectations. Notably, the search for meaning in life appeared crucial in forming clearer career goals, especially among young women in affluent countries. Additionally, self‐efficacy and parental support enhanced clarity in young men's career choices, while teacher support was crucial for adolescents’ career decision‐making in developing economies. These insights underscore the need for targeted support tailored to diverse socioeconomic contexts to promote clearer career trajectories for adolescents globally.
A Comprehensive Reinforcement Learning Framework for Priority‐Aware Data Center Scheduling Optimization and QOS‐Defined Buffer Management
Authors: Josephraj Vinu , Sundara Raj Wilfred Franklin 
Published: February 2025

ABSTRACTA network architecture's fundamental components include buffering designs and policies for their effective administration. Strong incentives exist to test and implement new regulations, but there are few opportunities to alter much more than minor details. We describe Open Queue, a new specification language that enables the expression of management rules and virtual buffering architectures that represent a broad range of economic models. Open Queue provides various comparators and basic functions that make it easy for users to create whole buffering structures and policies. It provides examples of Open Queue buffer management strategies and provides empirical evidence of how they affect performance in different scenarios. Through all of these efforts, minimizing network usage, avoiding network congestion, which ensures QoS (Quality of Service), and making the most use of the current route is regarded as the main problems. Common traffic engineering methods like Equal Cost Multipath (ECMP) don't address the state of the network at the moment or offer a mouse flow solution. The proposed solution to this issue is the implementation of a Deep Reinforcement Learning (DRL) based Priority‐Aware Data Center Scheduling Algorithm (PADCS), which leverages AHP‐TOPSIS to update previous experience using prioritized experiences replay, monitor workload categorization, and receive real‐time environmental feedback. Finally, the suggested algorithm determines the optimal route through the network for every flow depending on the kind of current flows in order to increase customer happiness and improve QoS. The evaluation findings show that, under various traffic scenarios, the DRL‐PADCS algorithm lowers average throughput and normalized total throughput, link usage, average round‐trip time, and packet loss rate in comparison to ECMP.
Multi‐sequential order transgressive cycles from the last interglacial to the Holocene revealed by deep‐core sediment facies analysis in the Baeksu tidal deposits, south‐west coast of Korea
Authors: Lim Serin , Kim Jin Cheul , Lim Dhongil , Kim Yongmi , Chang Tae Soo 
Published: February 2025

AbstractHigh‐resolution sequence analysis of three drill‐cores with well‐constrained optically simulated luminescence ages reveals a stratigraphic evolution of the Baeksu tidal flat (south‐west coast of Korea) that documents the development of tide‐dominated estuary infill interacting with minimal fluvial processes since marine isotope stage 6. The stratigraphic architecture and its correlation along an upper mudflat‐to‐subtidal transect showcase two different hierarchies of sequences and small‐scale (fifth‐order) subsequences that are nested within larger‐scale (fourth‐order) sequences. Two fourth‐order sequences with a frequency of 100 kyr consist of lower fluvial deposits and overlying tidal deposits, respectively, reflecting a twofold regressive–transgressive sedimentary sequence related to glacial–interglacial cycles. The sequence boundary is marked by an abrupt facies change from oxidised spit gravels (marine isotope stage 3) to tidal muds (marine isotope stage 1). An interesting feature is the presence of two packages of retrograding spit/tidal deposits corresponding to marine isotope stage 5a/b and marine isotope stage 3 interstadials deposited during short‐lived sea‐level rise, in spite of the long‐term phase of glacial sea‐level fall spanning from marine isotope stage 5d to marine isotope stage 2. Identification of deeply oxidised tidal deposits dated to marine isotope stage 5a/b confirms that two short‐term fluctuations in sea level occurred during the long‐lived glacial period. Such nested successions are assigned as fifth‐order subsequences with 40 kyr time intervals. The late Quaternary Baeksu tidal flat succession was thus mainly controlled by two different frequencies and magnitudes of sea‐level changes, associated with major interglacials (marine isotope stage 5e and 1) and minor interstadials (marine isotope stage 5a and 3). More importantly, transgressive episodes are significantly better preserved than regressive phases. This study provides a good example of how multi‐order, multiple transgressive deposition may be preserved in a tide‐dominated estuarine setting, particularly where river inputs are negligible.
Urban landscapes with more natural greenspace support higher pollinator diversity
Authors: Ulrich Jens , Sargent Risa D. 
Published: February 2025

AbstractAs cities around the world expand, we urgently need to better understand the drivers of urban biodiversity, especially for functionally important groups such as insect pollinators. In this study, we gathered hoverfly and bumble bee pollinator observations from natural history collections and community science initiatives from 462 urban landscapes across 85 US metropolitan areas. We tested whether urban greenspace functions as pollinator habitat by examining whether the total area of greenspace in an urban landscape predicted pollinator occurrence, that is, the presence or absence of species in a landscape. Our study was designed to determine whether there were differences between natural greenspace area (i.e., urban greenbelts, nature reserves and forest/grassland fragments) and developed greenspace area (i.e., managed parks, cemeteries and golf courses) in their ability to support a diversity of pollinator species. After accounting for sampling biases using an integrated occupancy modeling approach, we found a positive association between native hoverfly occurrence and natural greenspace area. This implies that urban landscapes with more natural greenspace support higher native hoverfly diversity. On average, bumble bee occurrence was not associated with natural greenspace area; however, the response varied among species, with several at‐risk bumble bees showing a positive association. In contrast to natural greenspace area, we found no association between pollinator occurrence and the area of developed greenspace. In addition, we found that the proportion of racial minority households in an urban landscape was negatively associated with pollinator occurrence. This is consistent with the hypothesis that a history of systematic, unjust policies in neighborhoods with more racial minority households has lasting negative impacts on urban biodiversity. In conclusion, our results support the hypothesis that natural greenspace functions as vital habitat for urban pollinators. We recommend that cities preservation of remnant natural greenspace and improve developed greenspaces in order to promote urban pollinator conservation. These efforts should be prioritized in urban landscapes with a higher proportion of racial minority households to improve equal access to nature and pollinator ecosystem services.
Enhancing the cooling effectiveness of concentrated photovoltaic systems using polyethylene terephthalate
Authors: Simoud K. , Chaker A. 
Published: February 2025

AbstractConcentrated photovoltaic systems convert solar energy into electrical and thermal energy, making effective cooling crucial for optimizing performance and preventing cell damage. This study aimed to enhance both electrical and thermal efficiency while protecting cells from heat damage by incorporating polyethylene terephthalate (PET) into conventional channels with aspect ratios of 25 and 30. Numerical simulations using FORTRAN evaluated the system's efficiency, and an economic analysis assessed how PET costs affected the levelized cost of energy (LCOE). The research focused on the optimal position and height of PET, as well as the influence of the incidence heat flux angle on efficiency. Results showed that adjusting PET height and position significantly improved CPV system performance, with peak thermal and electrical efficiencies of 64.9% and 9.72%, respectively, achieved at a Reynolds number of 1500 and an aspect ratio of 30. Increasing the aspect ratio and incidence heat flux angle further enhanced efficiency, with optimal results at an incidence heat flux angle 35° and an aspect ratio of 30. Additionally, PET reduced the LCOE compared to other materials, thereby lowering overall cooling system costs.
Relative role of rock erodibility and sediment load in setting channel slope of mountain rivers
Authors: Takahashi Naoya O. 
Published: February 2025

AbstractRock strength influences channel slope by altering substrate erodibility and the size of sediments supplied to the channels. Although the frequent presence of knickpoints at lithological boundaries indicates that rock erodibility significantly determines channel morphology, a growing body of field evidence suggests that the coarse sediment supply from less erodible rock units is a primary factor in channel steepening. To assess the relative effects of rock erodibility and imposed sediment load on channel slope, I studied five rivers in Tsugaru, northern Japan. These rivers flow through alternating volcanic rock and sedimentary rock. The minimum channel slope required to transport both in situ sediments and those supplied from upstream was calculated using slope component analysis. The findings suggest that sediment effects largely account for the observed variations in channel slope across both volcanic and sedimentary rocks. The proportion of channel slope not explained by the imposed sediment load was slightly higher in volcanic rock reaches than in sedimentary rock reaches, which can be attributed to the lower erodibility of volcanic rock. Based on the grain size distributions of volcanic and sedimentary rock particles and the calculated impacts of sediment load, I conclude that the coarse sediment supply from volcanic rock is the primary cause of the difference in channel steepness between the rock types in Tsugaru. Although this conclusion holds generally true across Tsugaru, certain reaches with locally high channel steepness exhibit more extensive bedrock exposure than adjacent gentler reaches, suggesting that contrasts in erodibility also play a significant role in determining the channel slope. Therefore, examining what factors alter the relative significance of rock erodibility and sediment load can enhance our understanding of how rock properties influence longitudinal stream profiles.
Chemometrics‐Based Aroma Profiling Reveals Changes in Citrus limon L. Peels During Drying: Advances in Monitoring Lemon Essence
Authors: Zemni Hassène , Lamine Myriam , Attia Jihène , Mankaï Melika , Khiari Ramla , Jallouli Selim , Salem Asma Ben 
Published: February 2025

ABSTRACTVolatile compounds produce the aroma of fruits such as Citrus limon and play a key role in fruit quality. Moreover, drying technology plays a significant role in aroma quality. To reflect the volatile differences and the dynamic change of volatile profiles of dried lemon peel as affected by drying methods, the volatile compounds of dried peel prepared under three drying methods were analysed by gas chromatography–mass spectrometry combined with chemometrics. According to the results, drying at 35°C allowed to obtain peels with high titratable acidity, high flavonoid content and high antioxidant activity. On the other hand, vacuum freeze drying allowed to obtain samples with high total soluble solids and highest polyphenol contents. Eight volatile compounds were identified, with beta‐and alpha‐pinene and limonene found to play an important role in the discrimination of the different drying processes, based on variable importance in projection ≥ 1.2. These substances might be responsible for what caused the significant flavour difference between differently dried peel flours. The combination of HS–GC–MS and chemometrics offers a valuable tool for the identification of type‐specific volatile markers in lemon peels. This study provided an important study for the improvement of processing and design technology and quality enhancement of C. limon peels, in order to meet consumer demand.