bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visual Field Mean Deviation Slopes: A Potential Primary Endpoint for Clinical Trials in Glaucoma Neuroprotection
Authors: De Moraes Carlos Gustavo , Lane Keith J. , Wang Xiao , Liebmann Jeffrey M. 
Published: November 2022

Abstract
The purpose of this retrospective, longitudinal study is to evaluate the relationship between MD slope from visual field tests collected over a short period of time (2 years) and the current United States’ Food and Drug Administration (FDA) recommended endpoints for visual field outcomes. If this correlation is strong and highly predictive, clinical trials employing MD slopes as primary endpoints could be employed in neuroprotection clinical trials with shorter duration and help expedite the development of novel IOP-independent therapies. Visual field tests of patients with or suspected glaucoma were selected from an academic institution and evaluated based on two functional progression endpoints: 1) five or more locations worsening by at least 7 dB, and 2) at least 5 test locations based upon the GCP algorithm. A total of 467 (76.6%) and 472 (77.4%) eyes reached Endpoints A and B, respectively, at any point in time. 359 (58.8%) eyes progressed faster than 0 dB/year, 278 (45.5%) faster than -0.5 dB/year, and 200 (32.7%) faster than -1.0 dB/year. It was found that eyes experiencing rapid 24-2 visual field MD slopes over a 2-year period were more likely to reach one of the FDA accepted endpoints during or soon after that period.
Gauge-flux-induced anti-parity-time symmetries for extreme manipulations of channel-drop tunneling
Authors: Wang Bing , Qin Chengzhi , Fan Shanhui , Lu Peixiang 
Published: November 2022

Abstract
Parity-time (PT) and anti-parity-time (APT) symmetries have provided important guiding principles in the researches of non-Hermitian physics. Particularly, the realization of APT symmetries in photonic systems usually relies on optical nonlinearities or indirect-coupling methods. Here, we reveal a linear, direct-coupling mechanism of introducing gauge-flux biasing into open-cavity systems to attain APT symmetries. We show that a π-flux biasing in a looped-resonator array can force a degeneracy between a pair of Bloch modes in the array. By further coupling the array to external bus waveguides, the system near the degeneracy point can be described by an APT-symmetric Hamiltonian. As gauge-flux varies, the system undergoes a spontaneous transition between APT and APT-broken phases, with which we can switch between two extreme cases of complete channel-drop tunneling and complete tunneling suppression. Moreover, by adding a PT-symmetric term onto the APT-symmetric Hamiltonian through applying an imaginary gauge-flux biasing, we also achieve extreme channel-drop amplifying effects by reaching the “lasing point” under the critical-coupling condition. Our work bridges the physical connection between synthetic gauge field and non-Hermitian APT symmetries, which may also find many applications from optical routing, switching to buffering and amplifying on a chip-scale platform.
Evaluation of the efficacy of varying xylanase to cellulase ratio on ruminal fermentation of untreated and alkali treated oat straw
Authors: Jabri Jihene , Abid Khalil , Yaich Hela , Malek Atef , Rekhis Jamel , Kamoun Mohamed 
Published: November 2022

Abstract
Two in vitro ruminal fermentation assays were conducted to study the effect of exogenous fibrolytic enzyme (EFE) supplementation on untreated and alkali treated oat straw. During the first experiment, five CellulasePLUS-XylanasePLUS (DyadicPLUS International Inc.) complexes (EFE): DEF1 (100% CellulasePLUS), DEF2 (100% XylanasePLUS), DEF3 (50% CellulasePLUS + 50% XylanasePLUS), DEF4 (75% CellulasePLUS + 25% XylanasePLUS), DEF5 (25% CellulasePLUS + 75% XylanasePLUS) at varying xylanase to cellulase ratio (between 0.49 and 2.2) were assessed at 0, 0.5, 1, 2, 3, 5, 10, 20, 30 µl/gDM. DEF1 and DEF2 were subject to higher doses 60 and 100 µl/g DM. 200 mg of grounded oat straw was anaerobically incubated with buffer solution, fresh ruminal fluid, and EFE. The gas production (GP) was measured during 96h of incubation. EFE supplementation improved the rate and extent of GP and exerted quadratic responses (p-value < 0.001) for most parameters. The highest results were recorded for DEF3 (xylanase to cellulase = 1.5) with its optimal dose D5 = 5µl/gDM. As compared to the control, DEF3 increased the GP, GP rate, OMD, VFA and ME by 63.7%, 144.7%, 77.2%, 135.5%, and 54.8%, respectively. The responses to EFE were dependent on dose rate and varying xylanase to cellulase ratio. DEF3 was reevaluated in second experiment on untreated, NaOH (OSS) and Urea (OSU) treated oat straw. DEF3 was less effective regarding GP, fermentation parameters, and estimated OMD, ME, and VFA of OSS and OSU. Therefore, selecting the best xylanase to cellulase ratio and its optimal dose depends on chemical composition of the targeted substrate because of enzyme-substrate specificity.
Dual-band metamaterial-based energy harvesting application for WLAN communication frequency bands
Authors: Ercan Murat , Tetik Gamze , Altintas Olcay , Tetik Erkan , Karaaslan Muharrem 
Published: November 2022

Abstract
The increasing need for energy has made energy harvesting applications a hot topic in the last few decades. Metamaterials that give effective results in harvesting have been presented and analyzed in various designs since the day they were discovered. In this study, a dual band metamaterial-based system that can harvest energy in the WLAN communication frequency band is proposed. The metamaterial with a novel double circle rings geometry is designed and investigated for energy harvesting both numerically and experimentally. A lumped element and no lumped element resonator are studied with copper covered dielectric substrate for perfect absorbance. S parameters give two peaks at 2.48 GHz and 5.00 GHz. The absorptions of the proposed metamaterial structure are 77.84% and 84.02% at these frequencies, respectively. After the experimental fabrication of the proposed structure, absorption is measured as 92.38% and 95.90% at 2.48 and 5.00 GHz, respectively. Finally, harvesting calculations are carried out. The absorption efficiencies of the proposed structure are found as 64% at 2.44 GHz and 68% at 5.00 GHz. A total harvest percentage of 30.32% is calculated as harvesting efficiency parameter at these frequencies. This study reveals that the proposed structure can be considered as potential EM energy harvesters at 2–6 GHz frequency range.
Spatial variation of physical and mechanical properties of tailings under different rainfall intensities and the interaction pattern
Authors: Nie Wen , Li Chenxi , Hu Jingwen , Saffari Pooya , Wang Wensong , Luo Minghau 
Published: November 2022

Abstract
With the continuous mining, a huge amount of mine waste has accumulated in tailing dams in China. The increasing frequency of abnormal rainfall in China poses a significant threat to the stability of tailings dams. It is important to study spatial variation of physical and mechanical properties of tailings for the process of dam destabilization due to rainfall. The Luomukeng tailings dam, Jiangxi province, China, was selected as the research object and the changes of physical parameters of tailings at different spatial locations under different rainfall intensities and influence on the tailing’s mechanical properties were studied. The correlations between the parameters were analyzed by Spearman correlation analysis. The results showed that rainfall led to particle migration, with a high number of fine particles repositioning. The greater the intensity of rainfall, the more significant the migration of particles, the more obvious the changes of physical and mechanical properties of tailings. Based on Spearman correlation analysis results, it was obtained that the change of inhomogeneity coefficient of tailings has the strongest effect on cohesion, and the change of water content has the strongest effect on friction angle.
Booster immunization with Ad26.COV2.S or Omicron adapted vaccine enhanced immune responses and efficacy against SARS-CoV-2 Omicron in non-human primates
Authors: Solforosi Laura , Costes Lea , Tolboom Jeroen , McMahan Katherine , Anioke Tochi , Hope David , Murdza Tetyana , Sciacca Michaela , Bouffard Emily , Barrett Julia , Wu Cindy , Hachmann Nicole , Miller Jessica , Yu Jingyou , He Xuan , Jacob-Dolan Catherine , Huber Sietske Rosendahl , Dekking Liesbeth , Chamanza Ronnie , Choi Ying , Boer Karin Feddes-de , Barouch Dan , Schuitemaker Hanneke , Zahn Roland , Wegmann Frank 
Published: November 2022

Abstract
Omicron spike (S) encoding vaccines as boosters, are a possible strategy to improve COVID-19 vaccine efficacy against Omicron. Here, non-human primates immunized twenty months earlier with Ad26.COV2.S, were boosted with Ad26.COV2.S, Ad26.COV2.S.529 (encoding Omicron BA.1 S) or a combination of both vaccines. All vaccines elicited a rapid increase in WA1/2020 and Omicron S antibody titers; Omicron BA.1 and BA.2 antibody responses were most effectively boosted by vaccines including Ad26.COV2.S.529. Independent of vaccine used, mostly WA1/2020-reactive or WA1/2020 and Omicron BA.1 cross-reactive B cells were detected. Boosting with vaccines including Ad26.COV2.S.529 provided slightly higher protection of the lower respiratory tract against Omicron BA.1 challenge compared with Ad26.COV2.S. Antibodies and cellular immune responses were identified as complementary correlates of protection. Overall, a booster with an Omicron-spike based vaccine provided moderately improved immune responses and protection compared with the original Wuhan-spike based vaccine, which still provided robust immune responses and protection against Omicron infection.
Acute lymphoblastic leukemia treatment outcomes in Kazakhstan: 10-year experience
Authors: Adusheva Aisha , Kemaykin Vadim , Kuttymuratov Asset , Dosayeva Saltanat , Burlaka Zhanna , Vildanova Ruzal , Zhakhina Gulnur , Sipenova Aigerim , Saparbay Jamilya , Kulkayeva Gulnara 
Published: November 2022

Abstract

Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults. The global burden of ALL was evaluated and in 2017, there were 64 thousand incident cases, and more than 52 thousand died. There is lack of information on epidemiology and burden of ALL in Kazakhstan, the largest Central Asian country. In total, 210 patients with ALL were treated National Research Oncology Center, Nur-Sultan, Kazakhstan. All consecutive patients were treated between 2010 and 2020. Diagnosis and subclassification of ALL were performed according to the immunophenotype classification of the European group for the Immunological characterization of leukemia (EGIL). We found correlation between age and gender, chemotherapy regimen and type of hematopoietic stem cell transplantation with overall survival. Death rate was significantly higher in female patients.. Males had higher mortality compared to women, p = 0.014. Five-year overall survival (OS) for females was significantly lower than for males, 23.6% and 36.6%, respectively. There was significantly longer five-year overall survival in group of patients who received HSCT than those with chemotherapy alone, 46.1 month versus 29.7 month respectively. Presented data is the first available data analysis of ALL incidence and treatment outcomes in Central Asia.
Pre-operative coil-embolisation of a large, myelon-compressing vertebral metastasis involving the artery of Adamkiewicz
Authors: Becker Lena S. , Becker Egon Robert , Stuebig Timo , Hinrichs Jan Bernd 
Published: November 2022

Abstract
Background The artery of Adamkiewicz (AKA) or arteria radicularis anterior magna, is the name of the thoracolumbar segment of the dominant radiculomedullary artery, supplying the anterior lower spinal cord in addition to the anterior spinal artery. Results of a meta-analysis by Taterra et al. [1] showed its prevalence in 84.6% of people, a predominantly single appearance, most commonly originating from the left intercostal or lumbar arteries (87.4%) between the levels of T8-L1 (89%) [1], and a mean diameter of 1 mm [2, 3]. The artery most commonly arises from the spinal branch of the posterior ramus of the segmental artery (subcostal, posterior intercostal, or lumbar artery), which in turn arises from the descending aorta. The distal portion of the AKA, together with the anterior spinal artery, forms a characteristic “hairpin” turn [4]. Its location and anatomical variability cause its vulnerability to injury, especially during surgical but also interventional procedures. Anatomical knowledge paired with accurate localization of the AKA is therefore an integral part in planning orthopedic/neurosurgical spine, aortic vascular surgery repair procedures and endovascular selective arterial embolizations in this area.
Case presentation In this case of a 73-year-old female patient with progression of a large, myelon-compressing vertebral metastasis of L1, protective, blood-flow-controlling occlusion of the proximal-most points of the artery of Adamkiewicz artery (AKA) and segmental spinal arteries was safely performed prior to surgical decompression and tumor debulking.
Conclusions Current evidence indicates that knowledge of AKA location and the amount of collateralization may help estimate the risk of post-interventional spinal cord injury.
Linear representation of graphs: applications to molecular graphs
Authors: Ashrafi Ali Reza , Bretto Alain , Faisant Alain 
Published: November 2022

Abstract
In this article we build a linear representation starting from a multigraph; this allows us to give an algebraic view of the multi-graph we are studying. We show that two isomorphic multi-graphs give equivalent representations ; conversely two equivalent representations give isomorphic multigraphs. For the clarity of the article we give at the beginning, classical results on representations , nevertheless these are specific to our graph representation.
MSC Classification: 05C25 , 20G05 , 20C15
The Significant Contribution of Pasteur Institute of Iran to COVID-19 Pandemic Control: A Successful Map over the Obstacles
Authors: Larijani Mona Sadat , Biglari Alireza , Sorouri Rahim , Salehi-Vaziri Mostafa , Doroud Delaram , Azadmanesh Keyhan , Fotouhi Fatemeh , Mostafavi Ehsan , Ramezani Amitis 
Published: November 2022

Abstract
Background

The present study aims to show the comprehensive effort of Pasteur Institute of Iran and its scientists regarding COVID-19 chaos management, related studies, achievements and vaccine production though there were many imposed challenges.

Methods

The relevant literature review was done through the associated data from national and international databases, published and under review research articles and also through reports obtained from official meetings with the heads of the related departments.

Results

The taken strategy adopted by Pasteur Institute of Iran was based on six arms including COVID-19 laboratory network establishment, vaccine research and production, monitoring of SARS-CoV-2 variants, diagnostic tests production, conduction of applied and basic research, and community management and support which eventually utilized appropriate technology for facilitating vaccination as well as the pandemic control at the right time.

Conclusion

The COVID-19 pandemic which was going to be a real crisis, led to a precise and great performance of Pasteur Institute of Iran owing to the unity of the scientists and the staff. COVID-19 pandemic has been managed by COVID-19 laboratory network set up, approved vaccines in collaboration with Cuba, evaluation and validation system of diagnostic and immunological COVID-19 kits, community Support and careful SARS-CoV-2 Variants Screening.
COVID-19 is not over yet and the role of Pasteur Institute of Iran in dealing with this pandemic is still pivotal. There are some other challenges to overcome such as preparation for any COVID-19 probable trend, data management and update, long-term safety and efficacy of the vaccines and providing supplies.
Outcomes of singleton preterm very low birth weight infants born to mothers with pregnancy-induced hypertension
Authors: Kim Hye-Rim , Lee Byoung KooK 
Published: November 2022

Abstract
The association between maternal pregnancy-induced hypertension (PIH) and neonatal mortality and morbidities in preterm infants has not been consistent. This study aimed to evaluate the influence of maternal PIH on mortality and morbidities in singleton infants with very low birth weight born before 30 weeks of gestational age using the Korean Neonatal Network (KNN) database. A total of 5,340 singleton infants with very low birth weight were registered in the KNN registry, who were born at 23+ 0 to 29+ 6 weeks of gestational age between January 2015 and December 2020. Baseline characteristics and neonatal mortality and morbidities were compared between infants with PIH and non-PIH mothers. Infants with PIH mothers had significantly higher odds of respiratory distress syndrome (OR 1.983; 95% CI 1.285–3.061, p = 0.002) and bronchopulmonary dysplasia (OR 1.458; 95% CI 1.190–1.785, p < 0.001) than infants with non-PIH mothers. After adjusting for potential confounders, there were no significant differences in severe intraventricular hemorrhage, periventricular leukomalacia, retinopathy of prematurity, or death during neonatal intensive care unit admission between infants with PIH and non-PIH mothers. This study showed that preterm infants with PIH mothers had an increased risk of neonatal respiratory morbidities, including respiratory distress syndrome and bronchopulmonary dysplasia.
Steady-state memory-phenotype conventional CD4+ T cells exacerbating autoimmune neuroinflammation in bystander manner via Bhlhe40/GM-CSF axis
Authors: Choi Je-Min , Cho Min-Zi , Lee Hong-Gyun , Yoon Jae-Won , Kim Gil-Ran , Koo Ja-Hyun , Taneja Reshma , Edelson Brian , Lee You Jeong 
Published: November 2022

Abstract
Memory-phenotype (MP) CD4+ T cells are a substantial population of conventional T cells that exist in steady-state mice, and their immunologic functions in autoimmune disease have not yet been studied. In this work, we unveil a unique phenotype of MP CD4+ T cells by analyzing single-cell transcriptomics and T cell receptor (TCR) repertoires. We found that steady-state MP CD4+ T cells exist regardless of germ and food-antigen which are composed of heterogenous effector subpopulations. Distinct subpopulations of MP CD4+ T cells are specifically activated by IL-1 family cytokines and STAT activators, revealing that the cells have TCR-independent bystander effector functions like innate lymphoid cell. Especially, CCR6high MP CD4+ T cells are major responders to IL-1β and IL-23 without MOG35 − 55 antigen reactivity, which gives them pathogenic-Th17 characteristics and allows them to contribute to autoimmune encephalomyelitis. We identified Bhlhe40 in CCR6high MP CD4+ T cells drives the expression of GM-CSF through IL-1β and IL-23 signaling, contributing to CNS pathology in experimental autoimmune encephalomyelitis. Collectively, our findings reveal clearly distinct effector-like heterogeneity of MP CD4+ T cells in steady state and CCR6high MP CD4+ T cells exacerbate autoimmune neuroinflammation by Bhlhe40/GM-CSF axis in bystander manner synergistically with antigen-specific T cells.
Dynamic Nomogram for predicting the severity of acute pancreatitis in adults and Decision Curve analysis: a single-center retrospective study
Authors: Xu Hao , Xu Xing-da , Tan Jie-hui , Yang Wang-jun , Xiao Wang , Zhang Xiao-lou , Zhang Si-yun , He Qun , Zhang Xiao-kang , Qian Jian-ping , Zhang Guo-wei 
Published: November 2022

Abstract
Objective
Acute pancreatitis (AP) is a common and unpredictable disease. Severity stratification and prognostic prediction play an important role in reducing the mortality of AP and improving its prognosis in the early stage. We aimed to establish a clinical prediction model by logistic regression analysis visualized by nomogram.
Methods
A total of 497 patients with AP in the Nanfang Hospital, Southern Medical University between January 2015 and January 2018 were retrospectively collected. 497 patients were randomly (ratio = 7:3) divided into the training cohort (N = 347) and the validation cohort (N = 147), and both cohorts were divided into non-severe acute pancreatitis (non-SAP) and SAP groups. Univariate and multivariate logistic regression analysis were used to identify the factors associated with the severity of AP. Based on multivariate logistic regression analysis, nomogram was established and validated. The performance, discrimination, and calibration of nomogram were conducted. Decision curve analysis was used to evaluate the net benefits and clinical usefulness of the prediction model.
Result
Multivariate logistic regression analysis showed that alcohol use, hyperlipidemia, gender, hypertension, ionized serum calcium and serum albumin were independent risk factors for SAP. The individualized nomogram showed good discrimination both in the training cohort (area under the receiver operating characteristic curve [AUC], 0.782) and in the validation cohort (AUC, 0.764) with good calibration. Decision curve analysis demonstrated that in terms of clinical usefulness, the nomogram was found to have some clinical values and can be used in clinical practice.
Conclusion
The proposed nomogram based on easy-to-obtain features are of high efficacy in predicting SAP patients, which may facilitate clinical decision-making.
A Leader-Follower Formation Control of Multiple Mobile Robots by Position-Based Visual Servo Method using Fisheye Camera
Authors: OH-HARA Shinsuke , Fujimori Atsushi 
Published: November 2022

Abstract
This paper presents a leader-follower formation control of multiple mobile robots by position-based method using a fisheye camera. A fisheye camera has a wide field of view and recognizes a wide range of objects. In this paper, the fisheye camera is first modeled on spherical coordinates and a position estimation technique is proposed by using an AR marker. This paper furthermore presents a method for estimating the velocity of a leader robot based on a disturbance observer using the obtained position information. The proposed techniques are combined with a formation control based on the virtual structure. The effectiveness of the proposed method is demonstrated by simulation and experiments using two real mobile robots.
F2GAN based few shot image generation for GMAW defects detection using multi-sensor monitoring system
Authors: zhu kanghong , Chen Weiguang , Hou Zhen , Wang Qingzhao , Chen Huabin 
Published: November 2022

Abstract
Multi-source information intelligent sensing and online evaluation of the weld are two challenging problems in complex welding scenes. The difficulty is particularly pronounced in different welding scenes, where the multi-source sensing data exists large system deviations and small welding defects sample data are at large. In this paper, we propose modified few shot image generation model Fusing-and-Filling GAN (F2GAN) for welding data augmentation. To verify the efficiency of the modified F2GAN, some experiments were performed with various welding conditions. Through our proposed welding data set augmentation approach, two welding quality classification models combining multiple information are designed. We show the final classification accuracy of normal, burn through, incomplete penetration and welding deviation is 96.60%. Our results are beneficial for welding monitoring and quality evaluation in complex welding scenes.