bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unlocking Phenotypic Plasticity Provides Novels Insights for Immunity and Personalized Therapy in Lung Adenocarcinoma
Authors: Wang Feng , Du Hongjuan , Li Bibo , Luo Zhibin , Tang Min , Zhu Lei 
Published: April 2022

Abstract
Background
Unlocking phenotype plasticity (UPP) has been shown to have an essential role in the mechanism of tumor development and therapeutic response. However, the clinical significance of unlocking phenotypic plasticity in patients with lung adenocarcinoma is unclear. This study aimed to explore the roles of unlocking phenotypic plasticity in immune status, prognosis and treatment in patients with lung adenocarcinoma (LUAD).
Methods
Differential expressed genes (DEGs) and clinical information of UPP were selected from the cancer genome atlas (TCGA) database, and the GO, KEGG enrichment analyses were performed. The independent prognostic genes were determined by univariate and multivariate Cox regression, and the UPP signature score was constructed. Patients with LUAD were divided into high- and low-risk groups according to the median of score, and the immunocytes and immune function, the gene mutation, drug sensitivities between the two groups were analyzed. Finally, the results were validated in the GEO database.
Results
Thirty-nine significantly differentially expressed genes were determined. Enrichment analysis showed that UPP-related genes were related to protein polysaccharides and drug resistance. The prognostic results showed that the survival of patients in high-risk group was poorer than that in the low-risk group (P < 0.001). In the high- and low-risk groups, single nucleotide polymorphism (SNP) and C > T are the most common dissent mutations. The contents of immune cells were significantly different between high- and low-risk groups. And the immune functions were also significantly different, indicating that UPP affects the immunity in LUAD. The results from TCGA were validated in the GEO.
Conclusion
Our research has proposed a new and reliable prognosis indicator to predict the overall survival. Evaluation of the UPP could help clinician to predict therapeutic responses and make individualized treatment plans in patients with LUAD.
Ubiquitin-Like Conjugation by Bacterial cGAS Enhances Anti-Phage Defense
Authors: Chen Zhijian (James) , Jenson Justin , Li Tuo 
Published: April 2022

Abstract
cGAS is an evolutionarily conserved enzyme that plays a pivotal role in immune defense against microbial infection1-3. In vertebrate animals, cGAS is activated by DNA to produce cyclic GMP-AMP (cGAMP)4,5 , which initiates a signaling cascade leading to the expression of a battery of immune defense genes6,7. In bacteria, cyclic dinucleotide (CDN)-based anti-phage signaling systems (CBASS) have been discovered8-11. These systems are composed of cGAS-like enzymes and various effector proteins that either kill bacteria or inhibit bacterial growth upon phage infection, thereby stopping phage spread. Of the CBASS systems reported, ~39% contain Cap2 and Cap3, which encode proteins with homology to ubiquitin conjugating (E1/E2) and deconjugating (DUB) enzymes, respectively8,12. Although these proteins have been shown to be required to prevent infection of some bacteriophages8, the mechanism by which the enzymatic activities exert anti-phage effect is unknown. Here, we show that Cap2 forms a thioester bond with the C-terminal glycine of bacterial cGAS and promote conjugation of cGAS to target proteins in a process that resembles ubiquitin conjugation. Mutations of the C-terminal glycine of cGAS abrogated its anti-phage activity in several CBASS systems, recapitulating the effect of mutating the active site cysteines of E1- and E2- like domains in Cap2. The covalent conjugation of cGAS increased the production of cGAMP. Through a genetic screen with mutagenesis of T4 phage, we identified the phage protein Vs.4. that antagonizes the effect of cGAS conjugation catalyzed by Cap2. Vs.4 bound to cGAMP with a Kd of ~30 nM and sequestered it. A crystal structure of Vs.4 bound to cGAMP showed that Vs.4 formed a hexamer that bound to three molecules of cGAMP. These results reveal a ubiquitin-like conjugation mechanism that regulates cGAS activity in bacteria and illustrate an arms race between bacteria and viruses through controlling the levels of CDNs.
Increasing Generalizability: Naïve Bayes Vs K-Nearest Neighbors
Authors: Pasha Fahad Mansoor 
Published: April 2022

Abstract
Marketing research is often criticized for lacking generalizability and inability to reproduce results. The problem lies in using models to fit data, rather than determining the predictive power of models in conditions of uncertainty. For instance, how does the predictive power of a model change when customer dynamics change? The current study suggests that marketing researchers can supplement existing research methods with non-probabilistic prediction methods, such as the kNN algorithm-based model. Unlike probabilistic models that rely on past outcomes to predict future events – and lose predictive power when newer events are observed - non-probabilistic models better capture uncertainty. In the current study, the predictive power of the kNN algorithm-based model and the Naïve Bayes model is compared using data from two real markets. The kNN algorithm-based model provides more accurate predictions, showing the utility of combining the kNN algorithm-based model with existing marketing research to improve the predictability and generalizability of models. Implications for research and future research are discussed.
Occupational health hazards among healthcare providers and ancillary staff in Ghana: a scoping review
Authors: Tawiah Philip Apraku , Baffour-Awuah Alberta , Effah Emmanuel Sintim , Ashinyo Mary Eyram , Alhassan Robert Kaba , Appiah-Brempong Emmanuel , Afriyie-Gyawu Evans 
Published: April 2022

Abstract
Background The safety of healthcare workers is a pathway to providing safe care to patients and their relatives, and yet healthcare providers and ancillary staff in developing countries such as Ghana are continuously exposed to occupational health hazards. The strict implementation of occupational health and safety policies seeks to curb these exposures. However, empirical evidence including reviews that are needed to affirm these policies is lacking in Ghana. This review primarily explored the types and prevalence of exposure to occupational health hazards among health workers in Ghana.Methods A scoping review design was employed for this study. A systematic search strategy was used to identify articles in PubMed, MEDLINE, CINAHL, Embase, PsycINFO, Scopus and Google scholar databases and search engines covering the period of 1 January 2010 to 30 November 2021. Additionally, key studies reference lists, and sources of grey literature were also searched to identify relevant articles. The articles were screened, and data of included articles were extracted and subsequently synthesized. The review considered only quantitative studies. An extensive protocol to this review has already been published elsewhere.Results Our systematic search strategy retrieved 507 publications; however, only 43 met the inclusion criteria. Healthcare professionals in Ghana were exposed to non-biological occupational hazards (stress, burnout, musculoskeletal injuries and violence), biological occupational hazards (sharp-related injuries, blood and body fluids and COVID-19 infection). But studies on exposure to non-biological hazards (34.9%) were more compared to biological hazards (20.9%). Averagely, health care workers utilized and complied to control/preventive measures (compliance to hand hygiene, face mask, infection prevention and control guidelines, hepatitis B vaccine uptake, adherence to HIV post-exposure prophylaxis protocol). Further, there was suboptimal knowledge of control/preventive measures (post-exposure prophylaxis, standard precautions, tuberculosis infection prevention and control measures, risk of exposure to occupational health hazards) among the healthcare personnel.Conclusion The menace of occupational health hazards in the health care sector of Ghana needs more attention. Though this review supports the existing data for occupational health and safety policy, more research is needed to understand the extent of these exposures and their effects on the health system.
Direction-of-Arrival Estimation in Non-Linear Array with Gain-Phase Error Compensation.
Authors: G Prabha , s Natarajamani , S Kirthiga 
Published: April 2022

Abstract
Gain and phase error sensitivity of the array output is common to all high-resolution direction of arrival estimators. In this paper, we addressed the estimation of directions of arrival of multiple signals impinging on a non-uniform linear array in the presence of gain and phase perturbations. The effect of amplitude and phase distortion on a non-uniform array with defective or missing elements is considered. An iteration method is proposed to estimate and compensate for these errors to ensure maximum accuracy in DOA estimation. Computer simulations are shown to verify the efficacy of the proposed algorithm with the presence of array distortions.
Analysis of behavior pattern and thermodynamic structure of Arabian Anticyclone in early onset of precipitation in south and southwest of Iran
Authors: Lashkari Hassan , Mohammadi Zainab 
Published: April 2022

Abstract
In Iran, due to its geographical location to the general circulation of the atmosphere and atmospheric systems adjacent to the time distribution of precipitation is not uniform. In the southern part, the main focus of the precipitation period is in autumn and winter, and by moving to the middle and northern latitudes, the precipitation period gradually lengthens and covers the autumn to spring seasons. According to the country's agricultural calendar, precipitation l is expected to start in early or mid-October. But in practice, due to the planetary and regional circulation characteristics, it sometimes happens sooner or later than normal conditions The purpose of this study is to identify synoptic patterns as well as the role of Arabian Anticyclone (AA) in the early onset of precipitation in south and southwestern Iran. For this purpose, daily precipitation of synoptic stations in the south and southwest of Iran in a statistical period of 36 years was extracted and based on the criteria set, early precipitation years were determined. Dominant synoptic patterns in these years were extracted using factor analysis and ocular inspection methods. In the following, the vertical structure and spatial displacement of the Arabian anticyclone have been investigated. The results of this study showed that in both patterns, Arabian anticyclone has been removed from its summer pattern earlier than normal conditions and according to the pressure level, it has been established in the area between the Hormoz Strait and the Aden Gulf. In both patterns, about 7 to 10 days before the onset of rainfall, a deep ridge of African anticyclone with the expansion of Northern (blocked in a pattern on northern Europe) intensifies the northern flows over the eastern Mediterranean and north-east Africa. This pattern with cold advection; in addition to deepening the Mediterranean trough and intensifying the activity of the Sudanese system is by the eastward displacement of the Arabian anticyclone. The vertical and horizontal profiles showed the eastward displacement of the Arabian anticyclone cores at least 15 days before the early precipitation.
PENGARUH PENERAPAN PPKM DARURAT PADA MASA PANDEMI COVID-19 TERHADAP PENURUNAN PENDAPATAN UMKM
Authors: Nasruddin Nasruddin , Yansari Qomariyah 
Published: April 2022

Abstrak: Penerapan PPKM Darurat bertujuan untuk mengurangi angka paparan Covid-19 sehingga dapat memutus rantai penularan virus. Penelitian ini bertujuan untuk menguji pengaruh penerapan PPKM Darurat terhadap penurunan pendapatan UMKM dengan menggunakan aplikasi pengolahan data spss 16.0. Penelitian ini melibatkan 30 orang responden yang terdiri dari pelaku UMKM di Desa Bandungsari, Sukodadi, Lamongan. Berdasarkan hasil penelitian menunjukkan bahwa terdapat pengaruh penerapan PPKM Darurat terhadap penurunan pendapatan bagi pelaku UMKM selama masa pandemi Covid-19. Pelaku UMKM yang sebelumnya bisa mendapatkan pendapatan lebih dari Rp300.000 per hari, pendapatannya menjadi merosot drastis hingga kurang dari Rp300.000 ketika dilaksanakan PPKM Darurat, mereka itu yang rata-rata bergerak di bidang toko kelontong, penjual sayur, dan pekerja serabutan yang memiliki usaha sampingan untuk menyambung hidup sehari-sehari. Hal tersebut terjadi akibat adanya peraturan yang membatasi jam operasional hingga pukul 20.00 WIB, adanya ketentuan makan/minum di tempat umum, misalnya bagi pemilik warung makan dilarang untuk melayani dine-in, serta membatasi 50 persen pengunjung yang membeli makanan dan minuman untuk dibawa pulang atau dengan menggunakan jasa pengantar makanan.
Kata Kunci: PPKM Darurat; Pandemi Covid-19; Penurunan Pendapatan UMKM; Pelaku UMKM

Abstract: The implementation of the emergency public activity restriction (Emergency PPKM) aims to reduce the number of exposure to Covid-19 so that it can break the chain of virus transmission. This study aims to examine the effect of implementing emergency public activity restrictions on the decline in MSME income by using the SPSS 16.0 data processing application. This study involved 30 respondents consisting of MSME actors in Bandungsari Village, Sukodadi, Lamongan. Based on the results of the study, shows that there is an effect of implementing emergency public activity restriction on the decline in income for MSME actors during the Covid-19 pandemic. MSME actors who previously could earn more than Rp300,000 per day, their income fell drastically to less than Rp300,000 when the emergency public activity restriction was implemented, they are mostly engaged in grocery stores, vegetable sellers, and freelancers who have a side business to survive daily. This situation occurs due to regulations that limit operating hours to 8 pm, provisions for eating/drinking in public places, for example, food stall owners are prohibited to serve dine-in, and limiting 50 percent of visitors who buy food/drinks to take home or by using food delivery services.
Keywords: Emergency PPKM; Covid-19 Pandemic; Decrease in MSME Income; MSME actors
KOMERSIALISASI RAMALAN TAROT OLEH TAROT READER DI KOTA SURABAYA
Authors: Tiananda Novena Clarissa , Alie Azizah , Elanda Yelly 
Published: April 2022

Abstrak: Artikel ini berbicara tentang praktik komersialisasi yang dilakukan oleh para tarot reader dan latar belakang tarot reader dalam mengkomersilkan ramalan tarot tersebut. Penelitian ini menarik karena terjadi di kalangan anak muda dan wilayah perkotaan yang cenderung rasional namun dalam kehidupannya masih percaya terhadap ramalan. Hal ini menjadi dasar para tarot reader untuk mengkomersilkan ramalan tarot pada kaum muda di Surabaya. Penelitian ini menggunakan metode kualitatif dengan pendekatan naratif melalui wawancara dengan tarot reader dan pengguna jasanya (konsumen). Penelitian ini menggunakan teori kekuasaan dan pengetahuan Michael Foucault dimana peramal (tarot reader) menggunakan pengetahuannya untuk mengkomersilkan ramalan tarot. Hasil penelitian ini menunjukkan bahwa terjadinya komersialisasi ramalan tarot dikarenakan adanya permintaan dari pengguna jasa, peluang usaha, kesadaran bahwa ilmu meramal tarot bisa menjadi sumber ekonomi atau penghasilan. Peramal tarot mempromosikan jasanya melalui media sosial dan konvensional (dari mulut ke mulut). Praktik komersialisasi yang dilakukan oleh tarot reader mulai dari proses dealing dengan pelanggan, proses peramalan, hingga penentuan tarif jasa didominasi oleh peramal (tarot reader).
Kata Kunci: komersialisasi; ramalan tarot; tarot reader; kekuasaan, pengetahuan

Abstract: This article talks about the commercialization practices carried out by tarot readers and the background of tarot readers in commercializing the tarot predictions. This research is interesting because it occurs among young people and urban areas who tend to be rational, but do not believe in predictions. This is the basis for tarot readers to commercialize tarot predictions for young people in Surabaya. This study uses a qualitative method with a narrative approach through interviews with tarot readers and service users (consumers). This study uses Michael Foucault's theory of power and knowledge where fortune tellers (tarot readers) use their knowledge to commercialize tarot predictions. The results of this study indicate that the commercialization of tarot divination is due to demand from service users, business opportunities, awareness that tarot fortune-telling can generate economic resources or income. Tarot fortune tellers promote their services through social media and conventional (word of mouth). Commercialization practices carried out by tarot readers, starting from the process of dealing with customers, to service fees are dominated by fortune-tellers (tarot readers).
Keywords: commercialization, tarot divination, tarot readers, power, knowledge
Beta Blockers can Mask not only Hypoglycemia but also Hypotension
Authors: Koracevic Goran , Micic Sladjana , Stojanovic Milovan , Radovanovic Radmila Velickovic , Pavlovic Milan , Kostic Tomislav , Djordjevic Dragan , Antonijevic Nebojsa , Koracevic Maja , Atanaskovic Vesna , Dakic Sonja 
Published: April 2022

Background:
Beta-adrenergic (β-AR) receptor blockers (BBs) are an essential class of drugs as they
have numerous indications. On the other hand, they have numerous unwanted effects that decrease the compliance,
adherence, and persistence of this very useful group of drugs.

Objective:
The paper aims to analyze the possibility that an unnoticed side effect may contribute to a less favorable
pharmacologic profile of BBs, e.g., a diminished reaction to a sudden fall in BP.

Methods:
We searched two medical databases for abstracts and citations (Medline and SCOPUS). Moreover,
we searched the internet for drug prescription leaflets (of the individual BBs).

Results:
Whichever cause of stress is considered, the somatic manifestations of stress will be (partially) masked
if a patient takes BB. Stress-induced hypercatecholaminemia acts on β-AR of cardiomyocytes; it increases heart
rate and contractility, effects suppressed by BBs. The answers of the organism to hypoglycemia and hypotension
share the main mechanisms such as sympathetic nervous system activation and hypercatecholaminemia.
Thus, there is a striking analogy: BBs can cover up symptoms of both hypoglycemia (which is widely known)
and of hypotension (which is not recognized). It is widely known that BBs can cause hypotension. However,
they can also complicate recovery by spoiling the defense mechanisms in hypotension as they interfere with the
crucial compensatory reflex to increase blood pressure in hypotension.

Conclusion:
Beta blockers can cause hypotension, mask it, and make recovery more difficult. This is clinically
important and deserves to be more investigated and probably to be stated as a warning.
Aminoquinoline-triazine Conjugates: Design, Synthesis, Antibacterial
Activity, and SAR Analysis
Authors: Bhat Hans Raj , Ansari Sajidul Hoque , Sahu Supriya , Shakya Anshul , Ghosh Surajit Kumar , Singh Udaya Pratap 
Published: April 2022

Aim:
Frequent use of antibiotics is responsible for the development of antibiotic resistance;
thus, there is an urgent need for the development of new antibacterial agents that act by novel mechanism
pathways.

Objective:
The aim of the study was to develop hybrid novel 4-aminoquinoline 1,3 5-triazine derivatives
and determine their antibacterial activity.

Methods:
Novel hybrid 4-aminoquinoline 1,3,5-triazine derivatives were synthesized by nucleophilic
substitution and characterized by different spectroscopic methods. Furthermore, in silico study was carried
out with 16S-rRNA A-site (PDB id: 1J7T using Discovery Studio 2018 software) to exemplify key
structural interactions. In vitro antibacterial activity of target compounds was evaluated against three
Gram-positive and three Gram-negative bacterial strains.

Result:
In silico results have shown compound 8c to have both hydrophobic interactions (conventional
hydrogen bond interactions with A A:16, A A:17 and carbon hydrogen bond with U A:14, G A:15) and
hydrophilic interactions (G A:18G A:13, G A:15 and U A:19) along with excellent CDocker energy (-
28.2942). In vitro antibacterial results revealed that compound 8c showed better zone of inhibition against
S. aureus (gram-positive) and E. coli (gram-negative) as compared to standard drug Cefixime.

Conclusion:
Our study demonstrated that in silico study supported the experimental study, and the developed
1,3,5-triazine-4-aminoquinoline derivatives may be used as potential leads for future antibacterial
drug development.
In Silico Identification of Novel Quinoline-3-carboxamide Derivatives
Targeting Platelet-Derived Growth Factor Receptor
Authors: Mhaske Ganesh S. , Sen Ashim K. , Shah Ashish , Khiste Rahul H. , Dale Ajit V. , Sen Dhanya B. 
Published: April 2022

Background:
Several computer-aided drug design (CADD) methods enable the design
and development of novel chemical entities. Structure-based drug design (SBDD) and the
knowledge of in silico methods enable the visualization of the binding process of ligands to targets
and to predict the key binding pocket sites and affinity of ligands to their target macromolecules.

Objective:
The present study was carried out to identify novel N-2-amino-N-phenyl quinoline-3-
carboxamide (AQCMs) derivatives targeting Platelet-derived growth factor receptor (PDGFR) to
cure cancer using in silico approach.

Materials and Methods:
AQCMs were designed using ChemAxon Marvin Sketch 5.11.5 software.
SwissADME and admetSAR online webserver were used to predict physicochemical properties as
well as the toxicity of compounds. Ligand-receptor interactions between quinoline-3-carboxamide
derivatives with the target receptor (PDB: 5GRN) were carried out using molecular docking technique
by employing various software like AutoDock 1.1.2, MGL Tools 1.5.6, Discovery Studio
Visualizer v 20.1.0.19295, Procheck, ProtParam tool, and PyMOL.

Results:
In silico results reveal that all designed compounds had acceptable pharmacokinetic properties,
were found to be orally bioavailable, and less harmful. Molecules from 36 to 39 showed better
docking scores as compared to standard drugs sunitinib and tasquinimod.

Conclusion:
Increase in binding energy and the number of H-bonds established by AQCMs with
below 3.40 Å distance interactions allows a valuable starting point in order to optimize compounds
for further investigation. Pharmacokinetics and toxicological profile build up the applicability of
quinoline-3-carboxamide moiety as a potential new candidate for the cure of cancer that could help
the medicinal chemists for additional extensive in vitro, in vivo chemical, and pharmacological
investigations.