bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Disaggregated analysis of the impact of fossil fuel consumption on carbon dioxide emissions in India: evidence from the TVP-VAR model
Authors: Ugur Mehmet Sedat , Çatık Abdurrahman Nazif , Sigeze Ciler , Balli Esra 
Published: December 2022

Abstract

This paper investigates the presence of time-varying effects of fossil fuel consumption on CO2 emissions in India. To accomplish this, the time-varying cointegration test developed by Bierens and Martins (2010) is employed to analyze the long-run relationship between the variables. According to the long-run time-varying coefficients, GDP has a positive and significant impact on emissions. This effect is increasing over time. The parameter estimates reveal the polluting effects of all fossil fuels. However, the positive effect of natural gas is found to be lower and less significant. Along with the cointegration analysis, the TVP-VAR model is used to investigate the short-run time-varying effects of fossil fuel use on CO2 emissions. The TVP-VAR findings also demonstrate that changes in income and fossil fuel consumption have a positive and significant impact on environmental degradation. Coal is found to be the most polluting fuel, followed by oil consumption. According to time-varying responses, increased natural gas consumption has a positive effect on emissions, but with the least influence when compared to other fossil fuels.
Diagnosis and analysis of a case of cat scratch disease combined with bacterial meningitis in a child
Authors: Jin Li , Wen Yang , Wang Yanjing , Li Yiyuan 
Published: December 2022

Abstract
Cat scratch disease is an infectious disease caused by the invasion of Bartonella henselae into the human body. Its clinical manifestations are diverse, but those presenting with neurological symptoms are rare, and cases of combined bacterial meningitis are even rarer. In this study, we report a case of a child with unexplained fever and neurological involvement, in which conventional anti-infective treatment was ineffective, and cat scratch disease was diagnosed with the metagenomics next-generation sequencing of whole blood. The cerebrospinal fluid examination suggested bacterial meningitis, and she was discharged after treatment.
Shuxuening injection with edaravone for cerebral infarction: A meta-analysis of randomized controlled trials
Authors: Wang Jiawei , Wang Canran , Li Lei , Zhi Hongwei , Meng Miaomiao , Zhang Yong , Na Zhang , Li Dayong , Wu Tong 
Published: December 2022

Abstract
Background: The ingredient of Shuxuening Injection (SXNS) is Ginkgo biloba extract, which is now often used as an adjunctive treatment for cerebral infarction. Edaravone is a free radical scavenger commonly used in China and Japan for the treatment of cerebral infarction. Currently, the combination of SXNS and edaravone often achieves good clinical efficacy in the treatment of cerebral infarction. The purpose of this study was to evaluate the efficacy of SXNS in combination with edaravone in the treatment of cerebral infarction.
Methods: As of May 20, 2022, an electronic database search was performed on some major Chinese and English databases to identify relevant randomized clinical trials (RCTs). The main outcome indicators included response rates, NIHSS scores, ADL scores, Fibrinogen and Barthel Index. Meta-analysis was performed using Stata 16.0 software.
Results: This meta-analysis showed that compared with edaravone therapy alone, SXNS combined with edaravone therapy has the following advantages in the treatment of cerebral infarction: (1) reduced neurological deficits(MD:-4.90, 95%CI:-6.26 to -3.53, p=0.00, I2=97.59%); (2) improved patients' quality of life, including improved Barthel Index (MD:4.58, 95%CI:2.24 to 6.93, p=0.00, I2=0.00%), improved ADL scores (MD:16.12, 95%CI:8.09 to 24.15, p=0.00, I2=47.92%) and improved Fibrinogen (MD:-19.73, 95%CI:-25.01 to -14.45, p=0.00, I2=99.62%); (3) improved response rates (RR:1.19, 95%CI:1.12 to 1.28, p=0.00, I2=53.98%).
Conclusions: SXNS combined with edaravone may have potential efficacy in reducing neurological deficits, improving quality of life and response rates in cerebral infarction. However, due to insufficient evidence, we were unable to draw any definitive conclusions. More high-quality trials are needed to provide stronger evidence and to assess the safety of SXNS in combination with edaravone.
Trial registration: This systematic review was registered with PROSPERO on 30 May 2022, and the registration number is: CRD42022333935.
Probiotic disruption of quorum sensing reduces virulence and increases cefoxitin sensitivity in methicillin resistant Staphylococcus aureus
Authors: Cella Monica Angela , Coulson Thomas , MacEachern Samantha , Badr Sara , Ahmadi Ali , Tabatabaei Mahdis Sadat , Labbe Alain , Griffiths Mansel William 
Published: December 2022

Abstract
Antimicrobial resistance is a growing threat to food safety, medical advancement, and overall global health. Methicillin resistant Staphylococcus aureus (MRSA) is typically a commensal species that, given an opportunity to establish an infection, transforms into a formidable pathogen with high rates of mortality and morbidity. Therefore, it is globally recognized that new therapies to combat this pathogen are desperately needed. A potential strategy in combating MRSA resistance and infections is the development of alternative therapeutics that interfere with bacterial quorum sensing (QS) systems involved in cell-to-cell communication. QS systems are crucial in the regulation of many virulence traits in MRSA such as methicillin resistance, exotoxin and surface protein expression, antioxidant production and immune cell evasion. Based on our previous research, in which we have shown that probiotic bioactive metabolites act as novel QS-quenching compounds, we propose in this letter that the same probiotic compounds can be used in tandem with a beta-lactam antibiotic to “re-sensitize” MRSA clinical isolates to cefoxitin. Moreover, we show that these probiotic metabolites decrease production of carotenoids and alpha-hemolysin in active cultures of MRSA, resulting in reduced toxicity and diminished resistance to hydrogen peroxide cytotoxicity in vivo.
Combinatorial Analysis of the ExponentialMap for Time-Evolution Operator
Authors: CEYLAN Ali Mert , AYTAÇ Vecdi 
Published: December 2022

Abstract
In this study, we present a novel formalization for exponential approximation. This formalization is for discrete analysis of continuous time-dependent perturbation operator of quantum mechanics, compared to multiplying exponentials. This leads us to Galton arrays for better representation and algebraic operations over exponential multiplications. Rotations on Galton arrays allow us to perform various algebraic operations and intuitively explain commutative and noncommutative operators equality in exponential approximations. Proposedalgebraic operations over Galton arrays will provide an easier understanding and a novel way to formalize and visualize multiplying exponentials. But most importantly, it focused on the time evolution operator to be written in the proposed formalization of time ordered multiplication of exponentials with noncommuting operators.
MSC Classification(2020): 81Q05 , 81Q15 , 81R60 , 81S05 , 81T75 , 82C99 , 52B70
Cancer epidemiological database linkage study of China (CEDLISC): Design, methods and quality evaluation
Authors: Zang Zhaoping , Sun Kexin , Zhang Mei , Zheng Rongshou , Zhao Yanfang , Zhang Siwei , Zhang Xiao , Wang Shaoming , Wang Xiaoxu , Chang Sheng , Liu Fen , Wang Limin , Wei Wenqiang 
Published: December 2022

Abstract
Connecting health related data from multiple databases is a novel approach for carrying out medical researches. Presently, the linkage of large medical databases in China is still underexplored. The Chinese Chronic Disease and Risk Factor Surveillance (CCDRFS) databases of years 2004–2015 with information on baseline risk factors for common chronic diseases were linked to the Population-based cancer registry (PBCR) database of China with information on cancer diagnosis and outcome. We used resident identification card numbers and combination of personal information variables as unique index variables for exact matching and fuzzy matching, respectively. Strict quality control procedures were performed based on the quality of databases and the logics of matched records. The 35–64 truncated incidence rate (TIR) and mortality rate (TMR) for all-cause of cancer in merged databases were used to select regions. 547,963 baseline records from the CCDRFS database were matched with 9,263 cancer diagnosis records from the PBCR database. Through quality control process, we created an epidemiology database of cancer incidence (EDCI) and an epidemiology database of cancer mortality (EDCM). The EDCI included 368,470 baseline records and 8,049 matched cancer incidences from 230 regions, with a 35–64 TIR of 309.54/100,000. The EDCM included 293,477 baseline records and 3,026 matched cancer mortalities from 183 regions, with a 35–64 TMR of 123.44/100,000. The database linkage and quality control methods were feasible in this study. The merged databases of cancer incidence and mortality were of high quality, which can provide scientific foundations for further cancer epidemiological studies.
The burden of disease for children diagnosed with Klinefelter syndrome – a European cohort
Authors: Andersen Ann-Louise Rud , Urhoj Stine Kjaer , Cavero-Carbonell Clara , Gatt Miriam , Gissler Mika , Klungsoyr Kari , Lelong Nathalie , Loane Maria , Morris Joan K , Neville Amanda , Pierini Anna , Tan Joachim , Tucker David , de Walle Hermien , Wellesley Diana , Garne Ester 
Published: December 2022

Abstract
Background
Klinefelter syndrome is a congenital chromosomal anomaly, where males have an extra X-chromosome. The syndrome may be associated with hypergonadotropic hypogonadism and many are late or undiagnosed. This European, population-based data-linkage cohort study was part of the EUROlinkCAT project and investigated the burden of disease for the first ten years of life for European children diagnosed with Klinefelter syndrome.
Results
Thirteen national and regional population-based registries in ten countries from the European surveillance of congenital anomalies (EUROCAT) network participated. Data for live born children born in 1995-2014 and diagnosed with Klinefelter syndrome prenatally or during infancy were linked to mortality and hospital records. Data for liveborn children born with any congenital anomaly and children without a congenital anomaly (reference children) were included for comparison on morbidity. Out of 5.8 million live born children 278 were diagnosed with Klinefelter syndrome in the 13 registry areas, 96.8% survived the first 5 year of life, 64.7% (95% CI 51.8;75.0) were admitted to hospital during the first year with a median length of stay of 3.9 (95% CI 3.0;4.7) days, 10.8% (95% CI 6.9;16.4) had a hospital stay of ≥10 days and 12.3% (95% CI 7.1;18.9) underwent surgery. In the age group 1-4 years of age 53.5% (95% CI 41.2;64.4) were admitted to hospital, the median length of stay decreased to 0.7 (95% CI 0.3;1.1) days and 6.3% (95% CI 2.6;12.3) had a hospital stay of ≥ 10 days.
Conclusions
More children diagnosed prenatally or in infancy with Klinefelter syndrome were hospitalised and underwent more surgery compared to reference children, while less were hospitalised and fewer had surgery than all children with any other congenital anomaly. Thus, the burden of disease was increased for children diagnosed prenatally or in infancy with Klinefelter syndrome but decreased overall after the first year of life.
Identification of the Inducible Activity in the Promoter of the Soybean BBI-DII Gene Exposed to Abiotic Stress or Abscisic Acid
Authors: Cheng Lishu , Dong Tao , Zhao Xu , Wei Shuang , Liu Kuocheng , Zhao Yan 
Published: December 2022

Abstract
The expression of the soybean Bowman–Birk proteinase isoinhibitor DII (BBI-DII) gene and the inducible activity of its promoter were studied under salt, drought, low temperature, and abscisic acid (ABA) exposure conditions. The BBI-DII gene was induced by salt, drought, low temperature, and ABA, and the relative expression levels at the peak were 103.09-, 107.01-, 17.25- and 27.24-fold, respectively, compared with the untreated control. The putative promoter, designated BP1 (− 1255 to + 872 bp), located 5’-upstream of the BBI-DII gene was cloned. The expression of the GUS gene in pCAM-BP1 transgenic tobacco plants was highest at 5 h after treatment with salt, drought, low temperature and ABA, especially under salt and drought. Using histochemical staining and fluorescence analysis of GUS, BP1 activity under salt and drought conditions after 5 h was 1.03 and 1.07-fold, respectively, compared with that of the CaMV35S promoter. Based on a 5’ deletion analysis, the segment (+ 41 to + 474 bp) was the basal region that responded to salt and drought, whereas the segment (− 820 to + 41 bp) was the area that responded to increased salt and drought activity. The BP2 (− 820 to + 872) activities were 0.98- and 1.02-fold compared with that of BP1 under salt and drought conditions and was 435 bp shorter than BP1. The salt- and drought-inducible activities of the BP2 promoter in the roots, stems, and leaves of transgenic tobacco plants were stable. Taken together, BP2 is more suitable than the BP1 promoter for the study and molecular breeding of stress-resistant soybean plants.
A Compact Adderless Feed-Forward Incremental Delta Sigma with Multiple Global References for CMOS Image Sensors
Authors: Callens Nicolas , Gielen Georges 
Published: December 2022

Abstract
This paper presents an adderless feed-forward incremental ΔΣ (IΔΣ) with asynchronous SAR (ASAR) that removes the need for in-column calibration by using global references, eliminates an additional summing amplifier and reduces the conversion time by using a multi-bit ASAR quantizer. The proposed IΔΣ ADC is designed in 40nm CMOS technology and is laid out compactly in a 5 μm x 466 μm column. According to post-layout simulations, the ADC achieves an input-referred noise of 85 μVrms, a conversion time of 3.2 μs (with DCDS) and a power consumption of 230 μW. This results in a Walden FoMW of 234 fJ/conv.step and a FoMA = FoMW x AADC of 0.54 fJ.mm2/conv.step, which demonstrates the feasibility of using the proposed architecture in CMOS image sensors.
Joint Resource Allocation and User Association for Multi-Cell Integrated Sensing and Communication Systems
Authors: Zhang Jiahui , Fei Zesong , Wang Xinyi , Liu Peng , Huang Jingxuan , Zheng Zhong 
Published: December 2022

Abstract
The densification of the orthogonal frequency division multiplexing (OFDM) based fifth-generation (5G) communication systems, as well as integrating sensing and communication functionalities, have promoted the development of integrated-sensing-and-communication (ISAC) dense cellular networks (DCNs). In the OFDM-based ISAC-DCN, multiple base stations simultaneously serve mobile users and sense targets based on the echo of downlink (DL) communication signals. In this paper, focusing on the interference management of the ISAC-DCN, we investigate the multi-dimension resource allocation problem. In particular, we aim at maximizing the network utility by jointly optimizing sub-band allocation, user association, and transmission power under the sensing signal-to-interference-plus-noise ratio (SINR) constraint. The problem is decomposed into three sub-problems. Subsequently, we propose a greedy genetic algorithm (GRGA) to solve the sub-band allocation sub-problem, and the Hungarian algorithm and successive convex approximation (SCA) technique are employed to execute user association and transmission power control, respectively. Simulation results show that the proposed algorithm significantly improves the network utility, achieves higher detection probability and illustrates the trade-off between sensing and communication performances.
Age-related attenuation of cortical synaptic tagging in the ACC and are rescued by BDNF or a TrkB receptor agonist in both sex of mice
Authors: Zhou Si-Bo , Xue Man , Liu Weiqi , Chen Yu-Xin , Chen Qi-Yu , Lu Jing-Shan , Wang Jinjun , Ye Keqiang , Li Xu-Hui , Zhuo Min 
Published: December 2022

Abstract

Long-term potentiation (LTP) is a key cellular mechanism for learning and memory, and recent studies in the hippocampus found that LTP was impaired in aged animals. Previous studies of cortical LTP have focused primarily on the homosynaptic plasticity in adult mice, while fewer studies have looked at heterosynaptic plasticity - such as synaptic tagging in aged mice. In the present study, we investigated synaptic tagging in the anterior cingulate cortex (ACC) of adult and middle-aged mice by using the 64-channel multielectrode dish (MED64) recording system. We found that synaptic tagging was impaired in the ACC of middle-aged male mice as compared to adult mice. Both the network L-LTP and the recruitment of inactive responses were reduced in the ACC of middle-aged male mice. Similar results were found in female middle-aged mice, indicating that there is no gender difference. Furthermore, bath application of brain-derived neurotrophic factor (BDNF) or systemic treatment with newly developed TrkB receptor agonists R13, was shown to rescue both synaptic tagging, and L-LTP, in middle-aged mice. To determine the distribution of synaptic LTP within the ACC, a new visualization method was developed to map the spatiotemporal variation of LTP in the ACC. Our results provide strong evidence that cortical potentiation and synaptic tagging show an age-dependent reduction, and point to the TrkB receptor as a potential drug target for the treatment of memory decline.
Diversity of metazoan parasites from fresh water fishes of Jammu (Southern slope of Siwaliks)
Authors: . Palaq , Langer Seema , Khurshid Ibraq , Saleem Saiqa , Bhat Bilal Ahmad 
Published: December 2022

Abstract
The present study was conducted to examine the diversity of metazoan parasites from freshwater fishes of Jammu. A total of 690 fishes were collected from three stations (Tawi, Chadwal and Sehi) and 9 species of parasites showing mixed infectivity were recovered viz., Euclinostomum heterostomum (A1 = 21.45%,χ2 = 72.16), Allocreadium schizothorascii (A2 = 29.71%,χ2 = 59.48), Argulus sp. (A3 = 30.43%,χ2 = 96.34), Lamproglena schizothorascii (A4 = 34.35%,χ2 = 107.48), Neoechinorhynchus sp. (A5 = 31.88%,χ2 = 60.98), Rhabdochona sp. (A6 = 45.21%,χ2 = 33.53), Strongyloides sp. (A7 = 41.30%,χ2 = 35.96), Contracaecum sp. (A8 = 52.75%,χ2 = 29.23), Camallanus(A9 = 29.27%,χ2 56.97)(p < 0.01).The seasonwise data indicates that highest rate of infection was found in spring and summer, followed by autumn and lowest rates of infection were found in winter. Maximum numbers of parasites were recovered from Station I (Tawi) which is due to maximum anthropogenic load that turns water body eutrophic thus making fishes more susceptible to parasites. The present study indicate highest parasitic infestation in Labeo sp. (1600 parasites, Rate of infection = 81.56%, χ2 = 17.75) from Station I with maximum number of species (8 out of 9) followed by Tor sp. (Rate of infection = 42.5%, χ2 = 4.4675), Oreochromis sp. (Rate of infection = 28.43% χ2 = 6.958) and others (Rate of infection = 68.01%, χ2 = 8.18). During the study, 1895 nematodes, 623 arthropods, 520 trematodes, 310 acanthocephalans were recovered. Cluster analysis using Euclidean distance between groups as similarity index algorithm yielded two main clusters wherein the nematode population was independent and more numerous than other parasite groups. PCA examination revealed a variance of 98.835% among the four parasitic groups which was represented using scree plot.
Serum miR-181а and miR-25 levels in patients with breast cancer or a benign breast disease
Authors: Perepechaeva Maria , Studenikina Anastasia , Proskura Andrew , Grishanova Alevtina , Autenshlyus Alexander 
Published: December 2022

Abstract
Breast tumours comprise a wide range of disorders requiring different and often personalised treatment plans. The microRNA levels indicating the regulation of gene expression involved in oncogenesis can serve as diagnostic and prognostic biomarkers of benign and malignant breast diseases. Circulating miR-181а and miR-25 were quantified here using droplet digital PCR (ddPCR) in 77 serum samples from patients with invasive breast carcinoma (IBC) (50 samples) or benign breast diseases (16 samples) and ‘potentially healthy’ controls (11 samples). МiR-181а expression was higher in patients with fibroadenoma or fibrocystic disease/adenosis (low risk of malignant transformation) as compared to potentially healthy controls. In IBC patients, miR-181a expression was higher in luminal B-like (HER2−), HER2+ (non-luminal) and triple-negative breast cancer (TNBC) groups, while miR-25 expression was higher in luminal B-like (HER2−) and TNBC groups compared to potentially healthy controls. Compared to the luminal A-like group, miR-181а expression was higher in luminal B-like (HER2−) and HER2+ (non-luminal) groups, whereas miR-25 expression was elevated in luminal B-like (HER2−) and TNBC groups. МiR-25 expression was higher in the luminal B-like (HER2−) group compared to the TNBC group. Thus, miR-181a and miR-25 may be markers of precancerous changes in women with benign breast diseases. In IBC patients, levels of miR-181a and miR-25 can reflect either favourable or adverse processes in a tumour owing to their multiple effects. They can be potentially used as biomarkers in a large diagnostic panel.
Cerebral embolic protection during transcatheter aortic valve replacement: a systematic review and meta-analysis of propensity score matched and randomized controlled trials using the Sentinel cerebral embolic protection device
Authors: Wolfrum Mathias , Handerer Immanuel Justus , Moccetti Federico , Schmeisser Alexander , Braun-Dullaeus Ruediger C , Toggweiler Stefan 
Published: December 2022

Abstract
Background
The Sentinel cerebral embolic protection device (CEP) aims to reduce the risk of stroke during transcatheter aortic valve replacement (TAVR). We performed a systematic review and meta-analysis of propensity score matched (PSM) and randomized controlled trials (RCT) investigating the effect of the Sentinel CEP to prevent strokes during TAVR.
Methods
Eligible trials were searched through PubMed, ISI Web of science databases, Cochrane database, and proceedings of major congresses. Primary outcome was stroke. Secondary outcomes included all-cause mortality, major or life-threatening bleeding, major vascular complications and acute kidney injury at discharge. Fixed and random effect models were used to calculate the pooled risk ratio (RR) with 95% confidence intervals (CI) and absolute risk difference (ARD).
Results
A total of 4066 patients from 4 RCTs (3’506 patients) and 1 PSM study (560 patients) were included. Use of Sentinel CEP was successful in 92% of patients and was associated with a significantly lower risk of stroke (RR: 0.67, 95% CI: 0.48–0.95, p = 0.02. ARD: -1.3%, 95% CI: -2.3 – -0.2, p = 0.02, number needed to treat (NNT) = 77), and a reduced risk of disabling stroke (RR: 0.33, 95% CI: 0.17–0.65. ARD: -0.9%, 95% CI: -1.5 – -0.3, p = 0.004, NNT = 111). Use of Sentinel CEP was associated with a lower risk of major or life-threatening bleeding (RR: 0.37, 95% CI: 0.16–0.87, p = 0.02). Risk for nondisabling stroke (RR: 0.93, 95% CI: 0.62–1.40, p = 0.73), all-cause mortality (RR: 0.70, 95% CI: 0.35–1.40, p = 0.31), major vascular complications (RR: 0.74, 95% CI: 0.33–1.67, p = 0.47) and acute kidney injury (RR: 0.74, 95% CI: 0.37–1.50, p = 0.40) were similar.
Conclusions
The use of CEP during TAVR was associated with lower risks of any stroke and disabling stroke with an NNT of 77 and 111, respectively.