bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperthyroidism and Radio-Iodine Therapy in a District General Hospital
Authors: Child D F , Mughni M A S S , Hudson P , Williams C P , Harvey J N 
Published: August 2022

A retrospective analysis was performed of 48 patients with hyperthyroidism (41 women aged 35–80, mean 56.6 years; 7 men aged 31–77, mean 52.1 years) treated with a fixed dose of 550 MBq 131I during a 12 month period May 1991-April 1992. Weight loss was common at presentation but 28.57% of women aged 35–49 years weighed over 80 kg compared to 9.98% in a standard UK population P>0.05. Patients treated with carbimazole (73%) prior to 131I had higher FT3 levels at presentation (14.0±4.4 pmol/l) compared to those (27%) who were considered not to require such treatment (8.9±1.4 pmol/l, P>0.001). Four months following radio-iodine, 67% were hypothyroid, 25% were euthyroid and 8% remained thyrotoxic and were retreated. Another patient became hypothyroid during 1 year of follow-up. Pre-treatment with carbimazole did not protect against the development of hypothyroidism (carbimazole treated 69% hypothyroid at 4 months, untreated 62% hypothyroid at 4 months). Patients with continuing thyrotoxicosis had very high FT3 levels at presentation (18.6, 21.1, 20 and in one patient reported only as > 10 pmol/l). A rationalized programme of follow-up assessments at 2, 3, 4, 8 and 12 months is suggested for patients treated with this dose of radio-iodine.
Through mindful colored glasses? The role of trait mindfulness in evaluating interactions with strangers
Authors: van der Schans Kim Lien , van Kraaij Janne AM , Karremans Johan C 
Published: August 2022

Converging evidence shows that mindfulness is associated with various indicators of interpersonal behavior and well-being. Although promising, the effects of mindfulness should ultimately be expressed during interpersonal interactions and observed by interaction partners. The current study assessed the associations between trait mindfulness, interpersonal stress, and interpersonal perceptions during stressful interpersonal tasks between strangers. Sixty-seven same sex stranger dyads (134 individuals; all females) participated in a laboratory study. Trait mindfulness was measured via an online questionnaire. In the lab, participants were asked to engage in two tasks with a stranger: (1) a stressful interaction task (they were asked to introduce themselves standing only 27 cm apart) and (2) a joint coordination task. Afterwards, both partners’ levels of interpersonal stress and interpersonal perceptions (i.e. liking of the interaction, perceived attentiveness, and perceived coping) were assessed. Results of Actor Partner Interdependence Models (APIM) showed a negative association between trait mindfulness and experienced interpersonal distress. Trait mindfulness was positively associated with liking of the interaction, perceived attentiveness and perceived coping. Actors’ trait mindfulness was positively associated with the partners’ liking of the interaction (marginally significant), but no other partner effects were found. There was no association between trait mindfulness and performance on the joint coordination task. The current findings underscore the importance of studying trait mindfulness dyadically. In actual interpersonal interactions, trait mindfulness positively affects interaction experiences of actors, but we found little support for a transfer to experiences of interaction partners. We discuss the implications of these findings in light of several theoretical models.
Efficacy and Safety of Erenumab, Galcanezumab, and Fremanezumab in the Treatment of Drug-Resistant Chronic Migraine: Experience in Real Clinical Practice
Authors: Cantarelli Lorenzo , Pestana Grafiña Diana , Gonzalez Perez Amanda , García Gil Sara , Gutiérrez Nicolás Fernando , Ramos Santana Emma , Navarro Dávila Marco Antonio , Otazo Pérez Sheila María , Calzado Gómez Gloria , Perez Reyes Sergio , Nazco Casariego Gloria Julia 
Published: August 2022

Background: Due to the recent introduction of new biologic drugs for chronic migraine, a global evaluation in real clinical practice is necessary. Objective: The objective was to evaluate the effectiveness and safety in real clinical practice of drugs targeting the calcitonin gene-related peptide receptor (CGRPr) in patients with chronic migraine. Methods: Single-center, restrospective study (2019-2022), including patients with chronic migraine treated with erenumab, galcanezumab, or fremanezumab. Effectiveness variables were recorded, namely, number of migraine headache days per month (MHD), Migraine Disability Assessment Scale (MIDAS) score, and Headache Impact Test–6 (HIT-6) score, assessing changes at week 12, 24 from baseline. Toxicity was recorded following the Common Terminology Criteria for Adverse Events (CTCAE) v5.0 criteria. Results: In all, 104 patients were included (46.2% erenumab, 41.3% galcanezumab, 12.5% fremanezumab). A reduction in MHD, MIDAS, and HIT-6 was achieved at weeks 12 and 24 with erenumab (p75% at week 24 than those intensified; P = 0.041). There was no difference in efficacy ( P = 0.154) or improvement in quality of life ( P = 0.783, P = 0.150), but there was greater toxicity ( P < 0.001) among nonresponders with erenumab 70 mg versus erenumab 140 mg. Conclusions: The results confirm the effectiveness and safety of anticalcitonin gene-related peptide (CGRP) drugs in real clinical practice. However, the study shows little benefit from erenumab intensification, with similar effectiveness and worse tolerability than the standard dose.
Analysis and Prediction of the Survival Trends of Patients with Clear-Cell Renal Cell Carcinoma: A Model-Based Period Analysis, 2001-2015
Authors: Du Sicong , Zhong Yu , Zheng Shuai , Lyu Jun 
Published: August 2022

Background Clear-cell renal cell carcinoma (ccRCC) is one of the most common malignant tumors worldwide whose poor prognosis results in a serious disease burden on patients. The changing trend of the long-term relative survival rates (RSRs) of patients with ccRCC was analyzed in this study to evaluate their treatment results over a 15-year period. Methods This study is a retrospective study, which assessed and predicted the 1-, 3-, and 5-year survival rates of patients with ccRCC during 2001-2005, 2006-2010, 2011-2015, and 2016-2020 using data extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Period analysis was used in this study to analyze the data from the SEER database and to assess survival differences according to age, sex, race, and socioeconomic status (SES) during the 15-year study period by comparing Kaplan-Meier curves. Results During 2001-2015, the 5-year RSR of patients with ccRCC increased from 78.4% to 83.0%, and the generalized linear model predicted that the 5-year RSR increased to 85.7% during 2016-2020. The RSR of patients with ccRCC differed significantly with SES, race, sex, and age. Compared with male patients, the survival advantage of female patients decreased as their age increased. The RSR of all patients with ccRCC was also lower in patients with a lower SES and of black race. Conclusion This study found an improvement in the RSR of patients with ccRCC during 2001-2020. Understanding the change trend of the survival rate of patients with ccRCC is helpful to improve the design of clinical trials. It also provides basic data and a scientific basis for evaluating the harm of ccRCC on the health of affected patients and the effect of cancer prevention, and developing cancer prevention plans.
Royal London Space Planning as a learning tool for postgraduate Orthodontic students. A mixed methods study
Authors: Ahmed Farooq , Sharma Pratik K 
Published: August 2022

Objective: To assess the effectiveness of the Royal London Space Planning (RLSP) as a learning tool among postgraduate orthodontic students as well as investigate students’ attitudes to its use. The RLSP tool is a structured method of orthodontic case assessment and treatment planning. Design: A prospective cohort study of first year postgraduate orthodontic students who attended teaching of the RLSP. Setting: Postgraduate teaching institute. Participants: First year postgraduate orthodontic students. Methods: The outcome measured was the accuracy in assessment and planning of a standardised orthodontic simulated case before and after teaching. Qualitative assessment was conducted through focus group and a semi-structured format after the teaching. Results: Nineteen students were included in the study. There was an overall improvement in assessment and planning of 20% after the teaching intervention ( P < 0.05). Assessment improved by 34% in comparison to treatment planning, which improved by 17% ( P < 0.05). The impact of the RLSP was most noticeable on the assessment of crowding in the lower arch which improved by 37% after teaching ( P < 0.05). Students felt using the RLSP tool made them more confident and was advantageous to use in training; most felt they would not use the tool after qualification. Conclusion: The RLSP tool is an effective method of teaching assessment and treatment planning to postgraduate orthodontic students. The effect of the RLSP is greater at assessments and less significant for treatment planning. The participant students felt the RLSP improved their confidence in assessment and treatment planning.
Closure of Post-thrombotic Iliac Arteriovenous Fistulas by Iliac Vein Recanalization
Authors: Schlager Oliver , Wolf Florian , Mueller Markus , Gschwandtner Michael E. , Loewe Christian , Koppensteiner Renate , Beitzke Dietrich , Willfort-Ehringer Andrea 
Published: August 2022

Purpose: The purpose of this study was to report the closure of iliac arteriovenous fistulas associated with a post-thrombotic iliac vein occlusion by iliac venous stent recanalization. Case Report: An 80-year-old woman presented with a worsening painful swelling of her left leg after an iliofemoral deep vein thrombosis 6 months ago. Duplex ultrasound and magnetic resonance venography revealed a post-thrombotic obstruction of her iliac veins as well as several arteriovenous fistulas between branches of her left external and internal iliac arteries and adjacent diseased venous segments. In a first attempt, coil embolization did not sustainably close these iliac arteriovenous fistulas. Direct stent recanalization of the chronically diseased iliofemoral venous segment, however, resulted in an immediate closure of arteriovenous shunt flow and subsequent improvement of clinical symptoms. Six months after iliac vein stent recanalization, still no fistulas could be detected any more, venous stents were fully patent, and the patient was free of symptoms. Conclusion: Post-thrombotic iliofemoral obstructions might be associated with the development of arteriovenous fistulas. Direct stent recanalization of the chronically occluded veins results in closure of related arteriovenous fistulas. Clinical Impact This case suggests that the combined occurrence of post-thrombotic venous obstructions with arteriovenous fistulas, which are related to aforementioned venous lesions, should be evaluated for primary venous stent recanalization rather than fistula embolization.
Tunisian Horehound (Marrubium vulgare) Aqueous Extract Improves Treatment of Bleomycin-Induced Lung Fibrosis in Rat
Authors: Abidi Anouar , Dhaouafi Jihen , Brinsi Chirine , Tounsi Haifa , Sebai Hichem 
Published: August 2022

Pulmonary fibrosis (PF) remains one of the most serious pneumopathies whose diagnosis and physiopathogenesis are still poorly understood and no treatment has been shown to be effective. Recently, many studies have shown a renewed interest in plants thanks to their pharmacological potentials, like horehound, known, for its anti-inflammatory and antioxidant activities. The present study investigated the effects of the aqueous extract of horehound (Mae) on bleomycin (BLM)-induced PF in rats. Thirty rats were divided into three groups. The control group received no treatment, the BLM group received only intratracheally BLM (2 mg/kg), and the Mae group underwent administration of BLM+ Mae (2 mL/kg) daily for 20 days. Obtained results showed that Mae, rich in polyphenols, could significantly improve the damage caused by BLM by reducing the inflammatory index and the fibrosis score, bringing the lung structure of fibrotic rats close to that of control rats. As well, Mae obviously acted on the BLM inflammatory reaction, and the counting of bronchoalveolar lavage fluid (Balf) cells showed an increase in total cell number and a decrease in the infiltration of inflammatory cells in the bronchoalveolar space. In addition, the BLM instillation was accompanied by oxidative stress in the lung, liver, and kidney tissues, proven by an increase in lipid peroxidation, as well as through depletion of superoxide dismutase (SOD) and catalase (CAT). The Mae treatment reversed all disturbances of BLM-induced oxidative stress parameters promoting antioxidant and anti-inflammatory of the latter. These findings point to Mae as a promising candidate for the treatment of pulmonary fibrosis.
Evaluating the concordance of functional MRI-based language lateralization and Wada testing in epilepsy patients: A single-center analysis
Authors: Campbell Justin M , Kundu Bornali , Lee James N , Miranda Michelle , Arain Amir , Taussky Philipp , Grandhi Ramesh , Rolston John D 
Published: August 2022

Background For patients with drug-resistant epilepsy, surgery may be effective in controlling their disease. Surgical evaluation may involve localization of the language areas using functional magnetic resonance imaging (fMRI) or Wada testing. We evaluated the accuracy of task-based fMRI versus Wada-based language lateralization in a cohort of our epilepsy patients. Methods In a single-center, retrospective analysis, we identified patients with medically intractable epilepsy who participated in presurgical language mapping (n = 35) with fMRI and Wada testing. Demographic variables and imaging metrics were obtained. We calculated the laterality index (LI) from task-evoked fMRI activation maps across language areas during auditory and reading tasks to determine lateralization. Possible scores for LI range from −1 (strongly left-hemisphere dominant) to 1 (strongly right-hemisphere dominant). Concordance between fMRI and Wada was estimated using Cohen’s Kappa coefficient. Association between the LI scores from the auditory and reading tasks was tested using Spearman’s rank correlation coefficient. Results The fMRI-based laterality indices were concordant with results from Wada testing in 91.4% of patients during the reading task ( κ = .55) and 96.9% of patients during the auditory task ( κ = .79). The mean LIs for the reading and auditory tasks were −0.52 ± 0.43 and −0.68 ± 0.42, respectively. The LI scores for the language and reading tasks were strongly correlated, r(30) = 0.57 ( p = 0.001). Conclusion Our findings suggest that fMRI is generally an accurate, low-risk alternative to Wada testing for language lateralization. However, when fMRI indicates atypical language lateralization (e.g., bilateral dominance), patients may benefit from subsequent Wada testing or intraoperative language mapping.
Factors predicting kindergarten teachers’ integration of science into their teaching in indigenous areas
Authors: Hsin Ching-Ting , Wu Hsin-Kai , Liang Jyh-Chong , Luu Di Tam 
Published: August 2022

Past studies have shown that kindergarten teachers find it challenging to integrate science into their instruction, but little is understood about factors that influence their science teaching in Indigenous areas. Our study aimed to investigate the associations between kindergarten teachers’ experiences, attitudes, self-efficacy, outcome expectations and science teaching. Partial least square structural equation modelling was employed to analyse 384 questionnaires from kindergarten teachers in Indigenous areas of Taiwan, teaching children aged 2–6 years. Results showed that self-efficacy had stronger predictive power over outcome expectations for the level of teachers’ science integration into teaching. Teachers’ mastery experience, perceived social support and attitude toward teaching diverse children significantly and positively predicted their science teaching self-efficacy and outcome expectations for Indigenous students. Moreover, teachers’ attitude toward diverse groups was significantly associated with their outcome expectations. This study sheds light on ways to enhance teachers’ early science teaching for culturally diverse students.
A Cryoprotectant-Gel Composite Designed to Preserve Articular Cartilage during Frozen Osteoarticular Autograft Reconstruction for Malignant Bone Tumors: An Animal-Based Study
Authors: Chen Chao-Ming , Chen Yi-Chun , Wang Jir-You , Chen Cheng-Fong , Chao Kuang-Yu , Wu Po-Kuei , Chen Wei-Ming 
Published: August 2022

Objective We designed a highly adhesive cryoprotectant-gel composite (CGC), based on regular liquid-form cryoprotectant base (CB), aiming to protect cartilage tissue during frozen osteoarticular autograft reconstruction for high-grade sarcoma around the joint. This study aimed to evaluate its effectiveness in rat and porcine distal femur models. Design Fresh articular cartilage samples harvested from distal rat and porcine femurs were divided into 4 test groups: untreated control group, liquid nitrogen (LN) freezing group, LN freezing group pretreated with CB (CB group), and LN freezing group pretreated with CGC (CGC group). Microscopic and macroscopic evaluation of cartilage condition, TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) assay, and apoptotic protein analysis of chondrocytes were performed to confirm our results. Results In the rat model, CGC could prevent articular cartilage from roughness and preserve more proteoglycans when compared with the LN freezing and CB groups. Western blot analysis showed CGC could prevent cartilage from LN-induced apoptosis supported by caspase-3/8 apoptotic signaling cascade. Macroscopically, we observed CGC could reduce both articular clefting and loss of articular luminance after freezing in the porcine model. In both models, CGC could reduce articular chondrocytes from degeneration. Fewer TUNEL-positive apoptotic and more viable chondrocytes in cartilage tissue were observed in the CGC group in our animal models. Conclusion Our study proved that CGC could effectively prevent cartilage surface and chondrocytes from cryoinjury after LN freezing. Freezing articular cartilage surrounded with high concentration of CGC can be a better alternative to preserve articular cartilage during limb salvage surgery for malignant bone tumor.
Feline eosinophilic sclerosing fibroplasia – a characteristic inflammatory response in sites beyond the gastrointestinal tract: case report and proposed nomenclature
Authors: Zampieri Bianca , Church Molly E , Walsh Koranda , Lennon Elizabeth M 
Published: August 2022

Case summary An adult male neutered Russian Blue cat presented for a right-sided nasal mass with bilateral retropharyngeal and right mandibular lymphadenomegaly. Medial retropharyngeal lymph node excision with nasal mass biopsy revealed eosinophilic sclerosing lymphadenitis and eosinophilic and lymphoplasmacytic rhinitis, respectively. Bacterial culture of the lymph node grew Pseudomonas aeruginosa, and treatment with pradofloxacin was started. Despite initial improvement, clinical signs recurred after 9 months, and fine-needle aspirates of the right mandibular and left medial retropharyngeal lymph nodes showed eosinophilic and mastocytic infiltration. Bacterial culture of the left medial retropharyngeal lymph node grew P aeruginosa, and treatment with anti-inflammatory doses of prednisolone and, later, marbofloxacin was instituted. Relevance and novel information This report describes a case of feline eosinophilic sclerosing lymphadenitis diagnosed outside of the abdominal cavity and is the first case reported to be associated with P aeruginosa. Feline eosinophilic sclerosing lymphadenitis should be considered as a differential for lymphadenopathy occurring in areas other than the abdominal cavity. Feline eosinophilic sclerosing lymphadenitis may develop in cats due to a species-specific inflammatory response to chronic bacterial and fungal infections.
Implementing Health Related Social Needs Screening in an Outpatient Clinic
Authors: Nohria Raman , Xiao Nan , Guardado Rubeen , Drainoni Mari-Lynn , Smith Cara , Nokes Keith , Byhoff Elena 
Published: August 2022

Introduction/Objectives: Health-related social needs (HRSN) screening efforts have reported high rates of identified social needs. Little is known if efforts to conduct HRSN screening in resource-constrained federally-qualified health centers (FQHC) successfully captures a representative patient population. Methods: This cross-sectional study extracted EMR data from 2016 to 2020 for 4731 screened patients from 7 affiliated clinics of a FQHC. Unscreened patients were pulled as a random sample from the study period. A multivariable logistic regression was used to identify sociodemographic traits, chronic disease diagnoses and burden, and clinic visit type and frequency associated with being screened for HRSN. Results: Our FQHC screened 4731 unique patients or <1% of the total clinic population. Screened patients had a median of 3.3 (±2.5) unmet HRSN. Medicaid patients had higher odds of being screened (aOR = 1.38, CI 1.19-1.61) relative to Medicare patients. The odds of being screened for social needs increased with more provider visits per year: compared to fewer than 1 visit per year, patients with 1 to 3 provider visits (aOR = 2.06, CI 1.73-2.32), 4 to 6 provider visits (aOR = 3.34, CI 2.89-3.87), and more than 6 provider visits (aOR = 5.16, CI 4.35-6.12) all had higher odds of social needs screening. Patients with a higher comorbid disease burden (>2 conditions, aOR = 2.80, CI 2.07-3.79) had higher odds of screening. Conclusions: Our findings demonstrate an increased likelihood to screen patients who visit outpatient services more often and have a higher comorbid disease burden. To meet state-level Medicaid requirements, resource-constrained FQHCs that implement clinic wide HRSN screening may be well served to identify a priori strategies to ensure representative and equitable screening across the patient population.