bluuebunny/crossref_metadata_2025_split huggingface dataset:
The transfer effects of computational thinking: A systematic review with meta‐analysis and qualitative synthesis
Authors: Ye Jiachu , Lai Xiaoyan , Wong Gary Ka‐Wai 
Published: September 2022

AbstractBackgroundComputational thinking (CT) is regarded as an essential 21st‐century skill, and attempts have been made to integrate it into other subjects. Instructional approaches to CT development and assessment in the field of computer science have attracted global attention, but the influence of CT skills on other subject areas is under‐researched.ObjectiveOur goal is to investigate the transfer effects of CT in different subject areas and examine the educational characteristics of CT intervention approaches that promote the transfer of learning.MethodWe carefully selected and reviewed 55 empirical studies from leading bibliographic databases and examined the transfer of CT using a meta‐analysis and a qualitative synthesis.Results and ConclusionsWe identified and summarized these effects in the fields of mathematics, science, engineering and the humanities. A meta‐analysis of these studies identified a generally significant effect of the transfer of CT skills to other subject areas. We also explored the characteristics of CT interventions that aid the transfer of learning by qualitatively assessing the identified studies. The results of the review offer a holistic view of the trends in CT transfer research that can be used as a reference for both researchers and instructors.
Impaired repair properties of endothelial colony‐forming cells in patients with granulomatosis with polyangiitis
Authors: Del Rio Ana Paula Toledo , Frade‐Guanaes Jéssica O , Ospina‐Prieto Stephanie , Duarte Bruno K L , Bertolo Manoel Barros , Ozelo Margareth C , Sachetto Zoraida 
Published: September 2022

AbstractIn patients with ANCA‐associated vasculitis, interactions between neutrophils and endothelial cells cause endothelial damage and imbalance. Endothelial colony‐forming cells (ECFCs) represent a cellular population of the endothelial lineage with proliferative capacity and vasoreparative properties. This study aimed to evaluate the angiogenic capacity of ECFCs of patients with granulomatosis with polyangiitis (GPA). The ECFCs of 13 patients with PR3‐positive GPA and 14 healthy controls were isolated and characterized using fluorescence‐activated cell sorting, capillary tube formation measurement, scratching assays and migration assays with and without plasma stimulation. Furthermore, three patients with active disease underwent post‐treatment recollection of ECFCs for longitudinal evaluation. The ECFCs from the patients and controls showed similar capillary structure formation. However, the ECFCs from the patients with inactive GPA exhibited early losses of angiogenic capacity. Impairments in the migration capacities of the ECFCs were also observed in patients with GPA and controls (12th h, p = 0.05). Incubation of ECFCs from patients with GPA in remission with plasma from healthy controls significantly decreased migration capacity (p = 0.0001). Longitudinal analysis revealed that treatment significantly lowered ECFC migration rates. This study revealed that ECFCs from the patients with PR3‐positive GPA in remission demonstrated early losses of tube formation and reduced migration capacity compared to those of the healthy controls, suggesting impairment of endothelial function.
Effect of chitosan‐based melatonin composite coating on the quality of minimally processed pomegranate aril‐sacs during cold storage
Authors: Mwelase Sbulelo , Opara Umezuruike L. , Fawole Olaniyi A. 
Published: September 2022

AbstractThe current study evaluated the potential of chitosan‐based melatonin (CH‐MT) composite coating to maintain quality and delay senescence of minimally processed pomegranate aril‐sacs during refrigerated storage. Mature pomegranate fruit (cv. Wonderful) without physical defects were processed into aril‐sacs. Subsequently, the following treatments were applied; distilled water (control), CH 0.5% (w/v), CH+0.1 mM MT, CH+0.4 mM MT, CH+0.8 mM MT, and CH+1 mM MT. Each treatment was applied by immersing the aril‐sacs in the coating solution for 3 min and allowed to dry at room temperature. Aril‐sacs were then packed in polyethene terephthalate punnets (three to four aril‐sacs/punnet) and stored at 5°C and 85% RH for 21 days. Aril color, weight loss, respiration rate, ascorbic acid content, total anthocyanins, browning index, and antioxidant capacity were monitored during storage at 3 days intervals. The study results showed that the CH‐MT coating treatments significantly (p < 0.05) delayed the increase in aril‐sacs weight loss and respiration rate. These treatments also retained higher aril chroma, ascorbic acid, anthocyanin content, DPPH‐radical scavenging activity, and aril‐sacs antioxidant power (FRAP). In addition, surface browning development was significantly suppressed in the coated aril‐sacs compared with control sacs. However, the effectiveness of CH‐MT treatments in maintaining the quality of aril‐sacs was concentration‐dependent, with CH+0.8–1 mM MT treatments showing the best results. Therefore, CH+0.8–1 mM MT treatments are recommended to suppress the development of physiological disorders and maintain the quality of minimally processed pomegranate aril‐sacs.Novelty Impact StatementThis study focuses on the development and application of chitosan‐melatonin composite coating (CH‐MT) as an active and functional formulation to maintain quality and extend the storage life of minimally processed pomegranate aril‐sacs. The results showed that incorporating melatonin with chitosan improved the effectiveness of chitosan base coating. This was demonstrated by the CH‐MT coating's enhanced retention of ascorbic acid, anthocyanins, radical scavenging activity, and antioxidant power. Further, delaying the increase in aril‐sacs surface browning, weight loss, and respiration rate. The study findings are valuable in the commercial adoption of safe preservation technologies to maintain the quality and maximize the storability of minimally processed products.
Association between early and current gastro‐intestinal symptoms and co‐morbidities in children and adolescents with Angelman syndrome
Authors: Leader G. , Whelan S. , Chonaill N. N. , Coyne R. , Tones M. , Heussler H. , Bellgard M. , Mannion A. 
Published: September 2022

AbstractBackgroundAngelman syndrome (AS) is a neurogenetic disorder that causes severe intellectual disability, expressive language deficits, motor impairment, ataxia, sleep problems, epileptic seizures and a happy disposition. People with AS frequently experience gastrointestinal (GI) symptoms.MethodThis study used data from the Global Angelman Syndrome Registry to explore the relationship between early and current GI symptoms and co‐morbidity in children and adolescents with AS (n = 173). Two groups that experienced a high (n = 91) and a low (n = 82) frequency of GI symptoms were examined in relation to feeding and GI history in infancy, sleep and toileting problems, levels of language and communication and challenging behaviours. Predictors of GI symptoms were then investigated using a series of logistic regressions.ResultsThis analysis found that constipation and gastroesophageal reflux affected 84% and 64%, of the sample, respectively. The high frequency of GI symptoms were significantly associated with: ‘refusal to nurse’, ‘vomiting’, ‘arching’, ‘difficulty gaining weight’, gastroesophageal reflux, ‘solid food transition’, frequency of night‐time urinary continence and sleep hyperhidrosis during infancy. GI symptoms were not significantly associated with sleep, toileting, language or challenging behaviours. Significant predictors of high frequency GI symptoms were gastroesophageal reflux and sleep hyperhidrosis.ConclusionsFuture research needs to investigate the association between AS and GI co‐morbidity in adults with AS.
Nevertheless, They Persisted: How Patterns of Opposition and Support Shaped the Survival of U.S. Abortion Clinics
Authors: Piazza Alessandro , Augustine Grace L. 
Published: September 2022

AbstractStigmatized organizations are generally assumed to face a variety of unique operational challenges. This paper examines the survival of stigmatized organizations in light of such challenges. Specifically, we investigate how patterns of opposition and support from multiple external stakeholders and audiences affect organizational survival within the context of abortion provision in the United States. We use a fuzzy‐set qualitative comparative analysis (fsQCA) to examine the causal linkages between the above factors and the survival outcomes of the full identifiable industry of 983 abortion clinics that were in operation in the U.S. between 2011 and 2017. Our results reveal the existence of multiple paths to survival, based primarily on either the absence of overt opposition or the presence of factors like political support that enabled organizations to overcome other threats to survival. Our findings show how socio‐political factors affect the survival of organizations in stigmatized industries.
Bullshit as a practical strategy for self‐deceptive narrators
Authors: Howe Leslie A. 
Published: September 2022

AbstractThis paper argues that bullshit is a practical resource for self‐deceiving individuals, or those who merely prefer to avoid self‐examination, insofar as it is able to provide a mask for poor doxastic hygiene. While self‐deception and bullshit are distinct phenomena, and bullshit does not cause self‐deception, bullshit disrupts the capacity to interrogate the motivational biasses that fuel deception. The communicative misdirection engaged in by ordinary social bullshitters is applied reflexively by the self‐deceiver to distort, evade, and obfuscate the self‐deceiver's self‐accounting. This discussion presupposes a broadly narrative approach to self‐awareness and discusses how a motivated susceptibility to bullshit offers an explanation how our reports about ourselves can be frequently at odds with reality, and suggests that a complacency about rational validation of belief outside of self‐certainty, i.e., the prevalence of bullshit, is even more of a threat than Frankfurt thought it to be.
Sally Lucas Jean, R.N. (1878–1971): Her historical legacy and lessons for contemporary public health nursing education
Authors: Carr Bryn , Scofield Elizabeth , Owens Janine , Donnelly Gloria , Aboul‐Enein Basil H. 
Published: September 2022

AbstractSally Lucas Jean, RN (1878–1971) pioneered health education in the United States and globally. At the time of her death in 1971, aged 93, her legacy included serving on boards of leading American health associations, spearheading public health projects worldwide and transforming thinking on contemporary public health education. Sally Lucas Jean's influence continues today, from her input on educational children's television programs, policies on child health and her involvement in developing the early foundations of health communication. In this historical reflection, we examine her role in defining health education and communication, alongside influencing and applying strategies to improve public health nursing.
Efficacy of ultraviolet A1 phototherapy for inflammatory, sclerotic and neoplastic dermatological diseases: A 10‐year tertiary referral center experience
Authors: Ronen Shachar , Ramot Yuval , Zlotogorski Abraham , Shreberk‐Hassidim Rony 
Published: September 2022

AbstractBackgroundUltraviolet (UV) A1 phototherapy is considered a beneficial treatment for various inflammatory, sclerotic, malignant, and other skin conditions. However, the available data regarding its efficacy for different indications, the potential side effects, and the recommended treatment protocols are sparse.ObjectivesTo assess the efficacy of UVA1 phototherapy and identify correlation between different indications and treatment protocols to response rates.MethodsWe performed a retrospective study of a cohort of 335 patients treated with UVA1 phototherapy at the Department of Dermatology at Hadassah Medical Center, Jerusalem, Israel, between 2008 and 2018.ResultsThe study population included 163 patients with inflammatory diseases (mainly atopic dermatitis and other types of eczema), 67 patients with sclerotic diseases (morphea and graft versus host disease), nine patients with neoplastic diseases (cutaneous T cell lymphoma), and 188 patients with other cutaneous disorders. Response rates ranged between 85% and 89% across indications, without differences in response rates among the indication groups (p = .941). In a multivariant logistic regression model, increased number of treatments and higher maximal dosages were associated with response to treatment (p < .001). Using ROC analysis, a cut‐off of 8 UVA1 phototherapy treatments was chosen as predictive for beneficial response (86.4% sensitivity, 78% specificity). A cut‐off of 40 J/cm2 was chosen as an optimal maximal dosage for differentiating between responders and non‐responders (51.1% sensitivity, 83.1% specificity).ConclusionsUVA1 phototherapy is an effective treatment for a variety of skin conditions. In most patients, at least eight treatments of a medium‐high dosage are required for clinical response.
Transcriptomic and methylation analysis of susceptible and tolerant grapevine genotypes following Plasmopara viticola infection
Authors: Azevedo Vanessa , Daddiego Loretta , Cardone Maria Francesca , Perrella Giorgio , Sousa Lisete , Santos Rita B. , Malhó Rui , Bergamini Carlo , Marsico Antonio Domenico , Figueiredo Andreia , Alagna Fiammetta 
Published: September 2022

AbstractDowny mildew, caused by the biotrophic oomycete Plasmopara viticola, is one of the most economically significant grapevine diseases worldwide. Current strategies to cope with this threat rely on the massive use of chemical compounds during each cultivation season. The economic costs and negative environmental impact associated with these applications increased the urge to search for sustainable strategies of disease control. Improved knowledge of plant mechanisms to counteract pathogen infection may allow the development of alternative strategies for plant protection. Epigenetic regulation, in particular DNA methylation, is emerging as a key factor in the context of plant–pathogen interactions associated with the expression modulation of defence genes. To improve our understanding of the genetic and epigenetic mechanisms underpinning grapevine response to P. viticola, we studied the modulation of both 5‐mC methylation and gene expression at 6 and 24 h post‐infection (hpi). Leaves of two table grape genotypes (Vitis vinifera), selected by breeding activities for their contrasting level of susceptibility to the pathogen, were analysed. Following pathogen infection, we found variations in the 5‐mC methylation level and the gene expression profile. The results indicate a genotype‐specific response to pathogen infection. The tolerant genotype (N23/018) at 6 hpi exhibits a lower methylation level compared to the susceptible one (N20/020), and it shows an early modulation (at 6 hpi) of defence and epigenetic‐related genes during P. viticola infection. These data suggest that the timing of response is an important mechanism to efficiently counteract the pathogen attack.
Dignity in nursing: A bibliometric and visual analysis of scientific publications
Authors: Liu Yu‐Jia , Li Xue‐Ying , Wang Yan‐Jie , Li Xiao‐Han 
Published: September 2022

AbstractBackgroundDignity‐conserved nursing has been widely studied by scholars all over the world; however, there is no clear direction in which this field is trending.AimTo conduct a bibliometric analysis that systematically characterises publications on dignity research in the nursing field from 2011 to 2020.DesignBibliometric and visual analysis of retrieved articles.MethodsThe Web of Science Core Collection database was used to retrieve all articles which addressed dignity in nursing from 2011 to 2020. The WoSCC's own analysis tool, CiteSpace and VOSviewer, were used to obtain visual analysis results. Reporting follows the STROBE checklist.ResultsA total of 1429 papers on dignity care are included in this study. We found that the number of papers on this topic increased steadily, and the United States topped the list with 366 articles in total. The institute with the most publications was King's College London, and the most widely published journal was Nursing Ethics. We were able to identify four major research topics, namely dignity in: (a) palliative care, (b) dementia and the elderly, (c) health care and (d) nursing ethics. Terminally ill patient, home, value, rehabilitation and psychological distress were the five keywords with the highest burst strength.ConclusionsThe interest in dignity care research has been steadily increasing from 2011 and is reflected in the number of published papers. The United States and Western Europe are leading in this field, both having a high number of cutting‐edge researchers and high‐level scientific research institutions. In the domain of dignity care, several stable and high‐yield core author groups have been formed. While the existing research mainly focuses on four hot spots, psychological distress, advanced cancer, maternity care and content analysis may be the research frontiers.
A conserved HSF:miR169:NF‐YA loop involved in tomato and Arabidopsis heat stress tolerance
Authors: Rao Sombir , Gupta Apoorva , Bansal Chandni , Sorin Celine , Crespi Martin , Mathur Saloni 
Published: September 2022

SUMMARYHeat stress transcription factors (HSFs) and microRNAs (miRNAs) regulate different stress and developmental networks in plants. Regulatory feedback mechanisms are at the basis of these networks. Here, we report that plants improve their heat stress tolerance through HSF‐mediated transcriptional regulation of MIR169 and post‐transcriptional regulation of Nuclear Factor‐YA (NF‐YA) transcription factors. We show that HSFs recognize tomato (Solanum lycopersicum) and Arabidopsis MIR169 promoters using yeast one‐hybrid/chromatin immunoprecipitation–quantitative PCR. Silencing tomato HSFs using virus‐induced gene silencing (VIGS) reduced Sly‐MIR169 levels and enhanced Sly‐NF‐YA9/A10 target expression. Further, Sly‐NF‐YA9/A10 VIGS knockdown tomato plants and Arabidopsis plants overexpressing At‐MIR169d or At‐nf‐ya2 mutants showed a link with increased heat tolerance. In contrast, Arabidopsis plants overexpressing At‐NF‐YA2 and those expressing a non‐cleavable At‐NF‐YA2 form (miR169d‐resistant At‐NF‐YA2) as well as plants in which At‐miR169d regulation is inhibited (miR169d mimic plants) were more sensitive to heat stress, highlighting NF‐YA as a negative regulator of heat tolerance. Furthermore, post‐transcriptional cleavage of NF‐YA by elevated miR169 levels resulted in alleviation of the repression of the heat stress effector HSFA7 in tomato and Arabidopsis, revealing a retroactive control of HSFs by the miR169:NF‐YA node. Hence, a regulatory feedback loop involving HSFs, miR169s and NF‐YAs plays a critical role in the regulation of the heat stress response in tomato and Arabidopsis plants.
Host‐associated variability of the cdtABC operon, coding for the cytolethal distending toxin, in Campylobacter jejuni
Authors: Guirado Pedro , Iglesias‐Torrens Yaidelis , Miró Elisenda , Navarro Ferran , Attolini Camile Stephan‐Otto , Balsalobre Carlos , Madrid Cristina 
Published: September 2022

AbstractCampylobacter, a major cause of food‐borne gastroenteritis worldwide, colonize the gastrointestinal tract of a wide range of animals, being birds the main reservoir. The mechanisms involved in the interaction of Campylobacter with the different hosts are poorly understood. The cytolethal distending toxin, encoded in the cdtABC operon, is considered a pivotal virulence factor during human infection. Differences in the prevalence of cdtABC genes in Campylobacter isolates from three distinct origins (wild birds, broiler chickens and humans) prompted us to further characterize their allelic variability. The sequence of cdtABC is highly conserved among broiler and human isolates. A high diversity of cdtABC alleles was found among wild bird isolates, including several alleles that do not produce any functional CDT. These results suggest that specific variants of the cdtABC operon might define the host range of specific Campylobacter jejuni isolates. Moreover, our data indicate that PCR methodology is inaccurate to characterize the prevalence of the cdt genes, since negative PCR detection can be the result of divergences in the sequence used for primer design rather than indicating the absence of a specific gene.
Changes in vastus lateralis fibre cross‐sectional area, pennation angle and fascicle length do not predict changes in muscle cross‐sectional area
Authors: Ruple Bradley A. , Mesquita Paulo. H. C. , Godwin Joshua S. , Sexton Casey L. , Osburn Shelby C. , McIntosh Mason C. , Kavazis Andreas N. , Libardi Cleiton A. , Young Kaelin C. , Roberts Michael D. 
Published: September 2022

New Findings
What is the central question of this study?
Do changes in myofibre cross‐sectional area, pennation angle and fascicle length predict vastus lateralis whole‐muscle cross‐sectional area changes following resistance training?

What is the main finding and its importance?
Changes in vastus lateralis mean myofibre cross‐sectional area, fascicle length and pennation angle following a period of resistance training did not collectively predict changes in whole‐muscle cross‐sectional area. Despite the limited sample size in this study, these data reiterate that it remains difficult to generalize the morphological adaptations that predominantly drive tissue‐level vastus lateralis muscle hypertrophy.

AbstractMyofibre hypertrophy during resistance training (RT) poorly associates with tissue‐level surrogates of hypertrophy. However, it is underappreciated that, in pennate muscle, changes in myofibre cross‐sectional area (fCSA), fascicle length (Lf) and pennation angle (PA) likely coordinate changes in whole‐muscle cross‐sectional area (mCSA). Therefore, we determined if changes in fCSA, PA and Lf predicted vastus lateralis (VL) mCSA changes following RT. Thirteen untrained college‐aged males (23 ± 4 years old, 25.4 ± 5.2 kg/m2) completed 7 weeks of full‐body RT (twice weekly). Right leg VL ultrasound images and biopsies were obtained prior to (PRE) and 72 h following (POST) the last training bout. Regression was used to assess if training‐induced changes in mean fCSA, PA and Lf predicted VL mCSA changes. Correlations were also performed between PRE‐to‐POST changes in obtained variables. Mean fCSA (+18%), PA (+8%) and mCSA (+22%) increased following RT (P < 0.05), but not Lf (0.1%, P = 0.772). Changes in fCSA, Lf and PA did not collectively predict changes in mCSA (R2= 0.282, adjusted R2 = 0.013, F3,8 = 1.050, P = 0.422). Moderate negative correlations existed for percentage changes in PA and Lf (r = −0.548, P = 0.052) and changes in fCSA and Lf (r = −0.649, P = 0.022), and all other associations were weak (|r| < 0.500). Although increases in mean fCSA, PA and VL mCSA were observed, inter‐individual responses for each variable and limitations for each technique make it difficult to generalize the morphological adaptations that predominantly drive tissue‐level VL muscle hypertrophy. However, the small subject pool is a significant limitation, and more research in this area is needed.