bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipophagy: A Potential Therapeutic Target for Diabetic Nephropathy
Authors: Yang Ming , Song Panai , Zhao Li , Wang Xi 
Published: July 2022

Abstract:
Diabetic nephropathy (DN) is a serious complication of diabetes mellitus and
one of the main causes of end-stage renal disease (ESRD). There are many factors causing
the progression of DN. Lipid metabolism disorder is a common clinical manifestation
of DN, and ectopic renal lipid deposition was recently proposed as a key factor promoting
the development of DN. Lipophagy is a newly discovered type of selective autophagy
that can remove excessive lipids in cells to maintain lipid homeostasis. Recently, abnormalities
in lipophagy have also been implicated in the progression of DN. Here, we
discuss the formation of lipid droplets, describe lipophagy and its key regulatory signals,
summarize the current research progress of lipophay in DN, and finally propose that
lipophagy may be a potential target for the treatment of DN.
A Review of CO2 Capture by Poly(Ionic liquid)s
Authors: Soni Rajdip , Biswas Rima 
Published: July 2022

Abstract:
Over the last two decades, poly(ionic liquid)s (PILs) have undergone extensive research and development. PILs have opened a whole new passage to versatile ionic polymers. It has compelled the chemical industry to rethink its modern ways of carbon capture. PILs have demonstrated excellent CO2 sorption capacities in comparison to their corresponding ionic liquids (ILs). The effects of the chemical structures of PILs on CO2 sorption, including the types of anion, cation, and backbone, have been discussed. This review aims to cover details of a large range of PILs along with their physical and structural properties, synthesis procedures, and the absorption power towards CO2. Imidazolium-based PILs are some of the strongest absorbents of CO2. On the other hand, PILs with amino acid (AA) anion seem to have a much-improved sorption capacity when compared PILs with the non-AA anionic part. PILs with hexafluorophosphate ion (PF6-) relatively absorb more CO2 compared to tetra-fluoroborate (BF4-) based PILs. The solubility of CO¬2 was increased with increasing pressure and decreased as temperature increased. The inclusion of hydroxyl groups in the polycation increased the interaction with CO2 molecules.¬ The COSMO-RS model was used to understand the molecular-level behavior of PILs in terms of their activity coefficients.
A Self-management App for People Living With Mild Dementia (PRIDE): Protocol for a Pre-Post Feasibility Study
Authors: Lee Abigail Rebecca , McDermott Orii , Guo Boliang , Roe James , Orrell Martin 
Published: July 2022

Background
With the rapid increase in the prevalence of dementia in the United Kingdom and beyond, the emotional, social, and economic burden on individuals, families, and health care services continues to rise. Currently, interventions that enable people living with dementia to better manage their condition and achieve a good quality of life are needed.

Objective
This study aimed to explore how the Promoting Independence in Dementia (PRIDE) app can promote and support the self-management of people living with mild dementia.

Methods
Feasibility of a pre-post study design incorporating the Reach, Effectiveness, Adoption, Implementation, and Maintenance framework will be studied. We will use up to 6 National Health Service Trusts as research sites and the Join Dementia Research website and accept self-referrals to recruit 60 to 90 people living with mild dementia. Participants will complete the PRIDE app intervention over 8 weeks with support from a dementia adviser facilitator. Measures exploring mood, physical well-being, and quality of life will be collected at baseline and at follow-ups at 3 and 6 months. Facilitators and National Health Service staff will be invited to complete interviews shortly after the intervention phase.

Results
Data collection began in June 2021 and is predicted to cease by the end of August 2022. Analysis of the quantitative measures will explore the impact of the PRIDE app on participants’ independence, mood, and quality of life. Interview data will discuss participant experiences, how the use of the app affected them, and if it has the potential to be successfully implemented and maintained in dementia services.

Conclusions
This study will show the potential reach, effectiveness, and adoption of the PRIDE app intervention in the lives of people with mild dementia. The findings from this study will inform future research on the PRIDE app and any further developments to improve its effectiveness.

International Registered Report Identifier (IRRID)
DERR1-10.2196/33881
Retention, Fasting Patterns, and Weight Loss With an Intermittent Fasting App: Large-Scale, 52-Week Observational Study
Authors: Torres Luisa , Lee Joy L , Park Seho , Di Lorenzo R Christian , Branam Jonathan P , Fraser Shelagh A , Salisbury Benjamin A 
Published: July 2022

Background
Intermittent fasting (IF) is an increasingly popular approach to dietary control that focuses on the timing of eating rather than the quantity and content of caloric intake. IF practitioners typically seek to improve their weight and other health factors. Millions of practitioners have turned to purpose-built mobile apps to help them track and adhere to their fasts and monitor changes in their weight and other biometrics.

Objective
This study aimed to quantify user retention, fasting patterns, and weight loss by users of 2 IF mobile apps. We also sought to describe and model starting BMI, amount of fasting, frequency of weight tracking, and other demographics as correlates of retention and weight change.

Methods
We assembled height, weight, fasting, and demographic data of adult users (ages 18-100 years) of the LIFE Fasting Tracker and LIFE Extend apps from 2018 to 2020. Retention for up to 52 weeks was quantified based on recorded fasts and correlated with user demographics. Users who provided height and at least 2 readings of weight and whose first fast and weight records were contemporaneous were included in the weight loss analysis. Fasting was quantified as extended fasting hours (EFH; hours beyond 12 in a fast) averaged per day (EFH per day). Retention was modeled using a Cox proportional hazards regression. Weight loss was analyzed using linear regression.

Results
A total of 792,692 users were followed for retention based on 26 million recorded fasts. Of these, 132,775 (16.7%) users were retained at 13 weeks, 54,881 (6.9%) at 26 weeks, and 16,478 (2.1%) at 52 weeks, allowing 4 consecutive weeks of inactivity. The survival analysis using Cox regression indicated that retention was positively associated with age and exercise and negatively associated with stress and smoking. Weight loss in the qualifying cohort (n=161,346) was strongly correlated with starting BMI and EFH per day, which displayed a positive interaction. Users with a BMI ≥40 kg/m2 lost 13.9% of their starting weight by 52 weeks versus a slight weight gain on average for users with starting BMI <23 kg/m2. EFH per day was an approximately linear predictor of weight loss. By week 26, users lost over 1% of their starting weight per EFH per day on average. The regression analysis using all variables was highly predictive of weight change at 26 weeks (R2=0.334) with starting BMI and EFH per day as the most significant predictors.

Conclusions
IF with LIFE mobile apps appears to be a sustainable approach to weight reduction in the overweight and obese population. Healthy weight and underweight individuals do not lose much weight on average, even with extensive fasting. Users who are obese lose substantial weight over time, with more weight loss in those who fast more.
ANALYTICAL METHOD VALIDATION OF GLICLAZIDE RELATED SUBSTANCES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD
Authors: T. S. SABHYATHA , BABU NARAYANA 
Published: July 2022

Objective: The present study was undertaken with the objective of method validation of a rapid, simple, cost-effective HPLC method for the determination of related substances of Gliclazide.
Methods: A simple, rapid, and specific method for analysis of gliclazide by a sensitive high-performance liquid chromatographic method is described.
Validation of the method is carried out by USP and ICH guidelines. The method was validated for parameters like accuracy, precision, linearity, specificity, robustness, and system suitability. These proposed methods are suitable for the determination of title drugs in quality control laboratories in the pharmaceutical industries.
Results: The mobile phase used for the chromatographic runs consisted of (450 ml) of acetonitrile and (550 ml) of water. The separation was achieved on the LiChroCART Supersher RP-8 column, (250 mm × 4.0 mm, 5 µm), using isocratic mode. Drug peaks were well separated and were detected by a UV detector at 235 nm, the method was linear at the concentration range. Gliclazide limit of detection (LOD) and limit of quantification (LOQ) was 0.003 and 0.01 while LOD and LOQ for Impurity-F were 0.003 and 0.01 respectively.
Conclusion: The presented validated method is rapid, economic, simple, accurate, sensitive, robust, specific, and linear. It can be used for routine analysis of gliclazide.
Students’ Grammatical Problems in Writing Paragraph at Academic Year 2019/2020 of STKIP PGRI Sumatera Barat
Authors: Anwar Syilvi , Siska Siska , Asty Herfyna 
Published: July 2022

Penelitian ini dilatar belakangi oleh pentingnya mempelajari grammar dalam menulis, khususnya menulis grammar dalam pengunaan tenses dalam paragraph writing di STKIP PGRI Sumatera Barat untuk mengetahui kesalahan-kesalahan yang dilakukan mahasiswa saat menulis paragraph writing. Penelitian ini merupakan penelitian yang menggunakan metode penelitian descriptive research dengan pendekatan qualitative research. Peneliti melakukan analisa pada source of data dar iparagraph writing mahasiswa dengan metode pengambilan sampel yaitu purposive sampling. Populasi penelitian ini adalah sebanyak 3 kelas dari program studi pendidikan bahasa inggris tahun ajaran 2019/2020, atau sebanyak 79 data mahasiswadengan instrument yaitu dokumen ceklis. Pengumpulan data dengan cara menganalisa lembar jawaban ujian mid semester mahasiswa sebanyak 79 lembar data. Hasil dari penelitian ini menunjukkan bahwa beberapa mahasiswa memiliki masalah dalam pengunaan grammar khusunya pada tenses yang tidaksesuaidenganaturan tenses itusendiri. Jadipenelitimenyimpulkanbahwa 8 data yang peneliti temukan didalam paragraph writing belum benar berdasarkan rules dari penggunaan tenses itu sendiri.
Kelayakan dan Praktikalitas Media Pembelajaran Thunkable Berbasis Android pada Materi Ketahanan Pangan Industri dan Energi Kelas XI IIS SMAN 1 Painan
Authors: Sandra Heru Kartika , Tanamir Momon Dt. , Afryansih Nila 
Published: July 2022

This study aims to determine and analyze the feasibility and practicality of Android-based thunkable learning media on industrial food security and energy materials for class XI IIS SMAN 1 Painan. The type of research used in this research is research and development (Research and Development). With a 4D model that includes 4 stages, namely: Define, Design, Development, Desiminate. The subjects in this study were students of class XI IIS as many as 64 students. The results of the study found that: 1.)Thunkable learning media based on Android is declared very feasible after analyzing data processing using Microsoft Excel so that the total score is 277 with a mean level of 4.85 and a percentage rate of 97% with “Very Eligible” category. 2.) Thunkable learning media based on Android is declared practical after processing the research data obtained from the questionnaire, and a practical test is carried out so that a total score of 2.204 is obtained with a mean level of 4.45 and a percentage of 89% in the "Very Practical" category. Keywords: Appropriateness, Practicality, Android.
Kelayakan dan Praktikalitas Media Pembelajaran Menggunakan Aplikasi Sparkol Videoscribe terhadap Motivasi Belajar Siswa pada Mata Pelajaran Geografi di SMA N 4 Bukittinggi
Authors: Asmawati Mai Liza , Rianto Slamet , Setriani Loli 
Published: July 2022

This study aims to determine and analyze the development, feasibility and practicality of Learning Media Development Using Sparkol Videoscribe on Students' Learning Motivation in Geography Subjects at SMA N 4 Bukittinggi.The type of research used in this research is research and development (Research and Development). The 4D model includes 4 stages, namely: Define, Design, Development, Desiminate. The subjects in this study were students of class XI IPS 1 and Class XI IPS 4 who took part in the geography learning process at SMA N 4 Bukittinggi in the academic year 2021/2022, with a total of 64 students.The results of the study found that: 1.) The development of the sparkol videoscribe learning media included validation from experts, namely media experts, education experts, and linguists. So that the media validation data is obtained and then processed with the Interaclass Coefitien Correlation (ICC) formula assisted by processing using the SPSS version 22 application for Windows, the result is 0.868. if the value is more than 0.5, it can be concluded that the level of validation is adequate. 2.) The sparkol videoscribe learning media was declared very feasible after analyzing data processing using Microsoft Excel so that the total score was 174 with a mean level of 4.37 and a percentage level of 87% with the predicate "Very Good". 3.) The sparkol videoscrieb learning media was declared practical after processing the research data obtained from the questionnaire, and a practical test was carried out so that a total score of 3875 was obtained with a mean level of 4.15 and a percentage of 83% in the "Very Practical" category. Keywords: Appropriateness, Practicality, Sparkol videoscribe.
Comparison and Contrast in Writing Data Analysis Students Thesis English Department
Authors: Saputri Devita Esa Dewi , Sesmiyanti Sesmiyanti , Sani Riny D. 
Published: July 2022

Penelitian ini dilatarbelakangi oleh ketertarikan peneliti untuk mengetahui kekurangan dalam menulis skripsi yang terjadi pada thesis mahasiswa wisuda angkatan 59 Pendidikan Bahasa Inggris di STKIP PGRI Sumatera Barat. Ada beberapa kekurangan yang peneliti temukan dalam thesis siswa pada saat pre observasi seperti ketidaktepatan penggunaan conjunction, transition, cause effect dan comparison contrast namun peneliti hanya fokus pada analisis comparison and contrast pada skripsi mahasiswa. Tujuan dari penelitian ini adalah untuk mengetahui apakah ada penggunaan comparison and contrast dalam skripsi mahasiswa dan menganalisis ketepatan atau ketidak tepatan penggunaan comparison and contrast. Penelitian ini dilakukan dengan menggunakan penelitian kualitatif dengan metode dokumen analisis. Populasi penelitian ini adalah sebanyak 21 skripsi mahasiswa Program Studi Pendidikan Bahasa Inggris STKIP PGRI Sumatera Barat wisuda ke 59. Penelitian ini menggunakan purposive sampling sebanyak 14 skripsi mahasiswa yang telah di analisi. Peneliti menggunakan dokumen analisis sebagai instrument pada penelitian ini. Pengumpulan data dengan cara membaca dan mencari data analisis pada skripsi mahasiswa wisuda ke 59. Hasil dari penelitian ini menunjukkan bahwa dari 21 skripsi mahasiswa di temukan 14 dokumen yang menggunakan comparison and contrast dan ditemukan penggunaan yang tepatguna dan tidak tepatguna.
Students Learing Strategies in Intensive Listening Subject at STKIP PGRI Sumatera Barat Academic Year 2020/2021
Authors: Saputri Ninda Lagu , Asty Herfyna , Autilla Rani 
Published: July 2022

ABSTRACTPenelitian ini dilatar belakangi oleh ketertarikan peneliti untuk melihat strategi siswa terhadap pembelajaran listening dalam belajar Bahasa Inggris di kampus STKIP PGRI Sumatera Barat. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana strategi siswa terhadap pembelajaran intensive listening dalam belajar bahasa inggris. Penelitian ini adalah penelitian quantitative Descriptive method dengan data yang diambil dari angket persepsi siswa terhadap strategi yang digunakan dalam pembelajaran intensive di kampus STKIP PGRI Sumatera Barat. Jumlah sample dalam penelitian ini sebanyak 67 siswa. Penelitian ini menggunakan purposive sampling dalam pengambilan sample. A structured item questionnaire dan wawancara digunakan sebagai instrument untuk teknik pengumpulan data. Hasil analisa data memperlihatkan bahwa strategi yang digunakan dapat mempermudah siswa dalam memahami pembelajaran. Peneliti menyimpulkan bahwa strategi yang digunakan bagus untuk meningkatkan kemampuan mendengarkan bagi siswa. Kata Kunci: Bahasa Inggris, Listening Strategi, Strategi Belajar
Pengembangan Media Pembelajaran Berbasis E-Learning Menggunakan Chamilo di SMAN 13 Padang
Authors: Nurkhofifah Nurkhofifah , Setriani Loli , Suryani Ade Irma 
Published: July 2022

The development of E-Learning-Based Learning Media Using Chamilo at SMA Negeri 13 Padang was motivated by the lack of use of e-learning learning media in the teaching and learning process.The purpose of this study was to determine the results of expert validation, teacher responses, student responses and the practicality of media at SMA Negeri 13 Padang. The research method used is Research and Development (R&D). The subjects in this study were students of class XI IPS SMA Negeri 13 Padang. The data analysis technique used in this research is validation analysis using ICC, Teacher Response, Student Response and Practicality.The results of the study show that: 1.) Making e-learning learning media using chamilo includes validation by experts in the fields of media, education, information technology and language. In order to obtain media validation data and process it using the Intereclass Coefficient Correlation (ICC) formula assisted by the SPSS program, the result is 0.934. If the result is more than 0.50, the validation level is considered appropriate. 2.) The results of the geography teacher's response at SMA Negeri 13 Padang are expressed in terms of an average score of 94% belonging to the very interested category. 3.) The results of student responses in the small group trial obtained an average percentage of 77% while in the large group trial the average percentage was 77.5%. 4.) and the practicality of the media obtained a percentage score of 88% with the category "very practical". This shows that the e-learning-based learning media that has been developed can be used in SMA Negeri 13 Padang. Kata Kunci : E-Learning, Chamilo, Media, Development
Analisis Pemahaman Konsep Matematika Ditinjau dari Minat Belajar Siswa Kelas XI IIS SMA PGRI 3 Padang
Authors: Syiapuri Zesni , Haryono Yulia , Juwita Ratulani 
Published: July 2022

This study aims to describe the understanding of mathematical concepts in terms of students' interest in learning transformation material. This research method is a descriptive analysis method with a qualitative approach. The subjects of this study were students of class XI IIS SMA PGRI 3 Padang in the 2021/2022 academic year. The sampling technique is based on the level of understanding of the concept and learning interests of students. The instruments used to collect data are in the form of tests, interest in learning questionnaires, and interviews. The results showed that students with high learning interest with high and moderate conceptual understanding were able to fulfill the indicators for restating a concept and applying concepts or algorithms to problem solve. Students with moderate learning interest with high and low concept understanding are less able to fulfill the indicators for restating a concept. Students with low learning interest with moderate and low concept understanding are not able to meet the indicators in restating a concept, applying concepts or algorithms in problem-solving, and presenting concepts in the form of mathematical representations. Keywords: Analysis Of Concept Understanding, Learning Interest
Pengembangan Formulasi Cookies Rendah Indeks Glikemik Dengan Substitusi Tepung Ubi Banggai Sebagai Upaya Alternatif Pencegahan Penyakit Degeneratif
Authors: Fitrasyah Siti Ika , Ariani Ariani , Rahman Nurdin , Tangkas I Made , Aiman Ummu , Nurulfuadi Nurulfuadi , Nadila Devi , Rakhman Aulia , Hijra Hijra , Pradana Fendi , Hartini Diah Ayu 
Published: July 2022

Banyak orang yang mengatakan bahwa semakin bertambahnya usia, maka penyakit yang diderita pun akan semakin banyak, salah satunya penyakit degeneratif. Untuk meningkatkan konsumsi pangan perlu didukung upaya pengadaannya yaitu melalui pengembangan pengolahan pangan lokal, seperti ubi Banggai. Formulasi cookies rendah indeks glikemik dengan substitusi tepung ubi banggai apakah dapat dijadikan camilan sebagai salah satu upaya untuk pencegahan penyakit degeneratif. Penelitian dilaksanakan pada bulan Maret sampai September 2021 bertempat di Universitas Tadulako dan Labkesda Provinsi Sulawesi Tengah. Produk cookies ubi banggai dapat dijadikan sebagai menu selingan alternatif untuk pencegahan penyakit degenerative dengan nilai Indeks Glikemik 33,6 (Rendah) dan beban Glikemik 15 (Sedang) . Namun untuk penelitian lebih lanjut perlu dilakukannya pendugaan umur simpan cookies ubi bangga, perbaikan tekstur produk, pengembangan SOP pembuatan produk khususnya literasi pada titik kritis pemanggangan dan pendinginan sehingga produk yang dihasilkan memenuhi standar kualitas yang ada. Kemudian perlu dilakukan juga pengembangan varian rasa baru untuk memberikan banyak pilihan pada konsumen.
Pengembangan Media Flash Card Berbahasa Minang Tentang Gula, Garam dan Lemak dalam Makanan Jajanan
Authors: Masri Erina , Adfar Tika Dwita , Primanofajra Melta 
Published: July 2022

Kurangnya pengetahuan siswa sekolah dasar tentang gula, garam dan lemak dalam makanan jajanan menyebabkan siswa sering mengkonsumsi makanan jajanan yang tinggi akan gula, garam dan lemak. Sehingga diperlukan media edukasi gizi yang sesuai dengan usia siswa sekolah dasar dan memiliki bahasa yang mudah di pahami, yaitu bahasa daerah. Penelitian ini bertujuan mengembangkan media flash card berbahasa Minang untuk meningkatkan pengetahuan siswa tentang gula, garam dan lemak dalam makanan jajanan di SD Kecamatan Koto VII Kabupaten Sijunjung menggunakan metode research and development (R&D). Hasil penelitian ini menunjukkan bahwa validasi ahli materi 100% dikatakan valid, validasi ahli desain 95,83% dikatakan valid, dan hasil uji coba produk pada siswa sekolah dasar terdiri dari tiga tahap, yaitu evaluasi satu lawan satu 97,91% dikatakan valid, evaluasi kelompok kecil 93,75% dikatakan valid, dan eveluasi lapangan 91,1% dikatakan valid. Uji paired samples T-Test menujukkan terdapat perbedaan yang signifikan antara pre-test (57,6%) dan post-test (84%) pengetahuan siswa tentang gula, garam dan lemak dalam makanan jajanan yang memiliki p value = 0,00 (P<0,05). Media flash card berbahasa Minang tentang gula, garam dan lemak dalam makanan jajanan efektif meningkatkan pengetahuan siswa di SD Kecamatan Koto VII Kabupaten Sijunjung.