bluuebunny/crossref_metadata_2025_split huggingface dataset:
An integrated strain-level analytic pipeline utilizing longitudinal metagenomic data
Authors: Zhou Boyan , Wang Chan , Putzel Gregory , Hu Jiyuan , Liu Menghan , Wu Fen , Chen Yu , Pironti Alejandro , Li Huilin 
Published: September 2022

Abstract
Background
With the development of sequencing technology and analytic tools, studying within-species variations enhances the understanding of microbial biological processes. However, most existing methods for strain-level analysis do not allow for the simultaneous interrogation of strain proportions and genome-wide variants in longitudinal metagenomic samples.
Results
In this study, we introduce LongStrain, an integrated pipeline for the analysis of large-scale metagenomic data from individuals with longitudinal or repeated samples. In LongStrain, we first utilize two efficient tools, Kraken2 and Bowtie2, for the taxonomic classification and alignment of sequencing reads respectively. Then, we propose to jointly model strain proportions and shared haplotypes across samples within individuals, which greatly improves the efficiency and accuracy of strain identification. With extensive simulation studies of a microbial community and single species, we show that LongStrain is superior to three popular reference genome-based methods in variant calling and strain-proportion estimation. Furthermore, we illustrate the potential applications of LongStrain in the real data analysis of The Environmental Determinants of Diabetes in the Young study and a gastric intestinal metaplasia microbiome study.
Conclusions
The proposed analytic pipeline demonstrates marked statistical efficiency over same type of methods and has great potential in understanding the genomic variants and dynamic changes at strain level.
Topical application of an irreversible small molecule inhibitor of Lysyl Oxidases ameliorates skin scarring and fibrosis
Authors: Chaudhari Nutan , Findlay Alison , Stevenson Andrew , Clemons Tristan , Yao Yimin , joshi Amar , Sayyar Sepidar , Wallace Gordon , Rea Suzanne , Toshniwal Priyanka , Deng Zhenjun , Melton Philip , Hortin Nicole , Iyer Swaminatha , Jarolimek Wolfgang , Wood Fiona , Fear Mark 
Published: September 2022

Abstract
Scarring is a lifelong consequence of skin injury, with scar stiffness and poor appearance presenting physical and psychological barriers to a return to normal life. Lysyl oxidases are a family of enzymes that play a critical role in scar formation and maintenance. Lysyl oxidases stabilize the main component of scar tissue, collagen, and drive scar stiffness and appearance. Here we describe the development and characterisation of an irreversible lysyl oxidase inhibitor, PXS-6302. PXS-6302 is ideally suited for skin treatment, readily penetrating the skin when applied as a cream and abolishing lysyl oxidase activity. In murine models of injury and fibrosis, topical application reduces collagen deposition and cross-linking. Topical application of PXS-6302 after injury also significantly improves scar appearance without reducing tissue strength in porcine injury models. PXS-6302 therefore represents a promising therapeutic to ameliorate scar formation, with potentially broader applications in other fibrotic diseases.
Occlusion-robust workflow recognition with context-aware compositional ConvNet
Authors: Zhang Min , Hu Haiyang , Li Zhongjin , Chen Jie 
Published: September 2022

Abstract
Workflow recognition relying on deep convolutional neural network has obtained promising performance. Though impressive results have been achieved on standard industrial workflow, the performance on heavily occluded workflow remains far from satisfactory. In this paper, we present an effective context-aware compositional ConvNet (CA-CompNet) for occluded workflow detection with the following contributions. First, we combine compositional model and original ConvNet together to build a unified deep architecture for occluded workflow detection, which has shown innate robustness to address the problem of object classification under occlusion. Second, in order to overcome the variable occlusion limitations, the bounding box annotations are utilized to segment the context from target workflow instance during training. Then, these segmentations are used to learn the proposed CA-CompNet, which enables the network to untangle the feature representation of workflow instance from the context. Third, a robust voting mechanism for candidate bounding box is introduced to improve the detection accuracy, which facilitates the model to precisely detect the bounding box of a specific workflow instance. Comprehensive experiments demonstrate that the proposed context-aware network can robustly detect workflow instance under occlusion in industrial environment, increasing the detection performance on MS COCO dataset by 1.4% in absolute performance compared to the advanced CenterNet.
Comprehensive analysis of the association between human diseases and water pollutants
Authors: XinluJiang  , Ding Kaiyang 
Published: September 2022

Abstract
Drinking water is an important natural resource. For many people around the world, especially in developing countries, access to safe drinking water is still a distant dream. An increasing number of human activities and industrialization have caused various physical, chemical and biological pollutants to enter water bodies, affecting human health. Efforts to figure out an effective method to predict water pollution poisons and human diseases have increased worldwide. Water pollutants contain a vast number of additives such as perfluorinated chemicals, polybrominated diphenyl ethers, phthalate, nanomaterials, insecticides, microcystins, heavy metal and pharmacologies. Here, we explored an integrative approach to identify genes, biological processes, molecular functions, and diseases linked to exposure to these water pollutants. These processes and functions affected by water pollutants are related to the many diseases, including colonic neoplasms, breast neoplasms hepatitis B, bladder cancer and human cytomegalovirus infection. Therefore, conducting an integrative toxicogenomic analysis of water pollutants are more appropriate for evaluating the potential effects of plastics in human health.
The Topographic Representation of Time and its Link With Temporal Context and Perception
Authors: Kulashekhar Shrikanth , Fortunato Gianfranco , Maass Sarah , Rijn Hedderik van , Bueti Domenica 
Published: September 2022

Abstract
Neuronal tuning and topography are mechanisms widely used in the brain to represent sensory information and also abstract features like time. In humans, temporal topography has been shown in a wide circuit of brain regions. However, it is unclear whether chronotopic maps are specific to vision, whether they map time in an absolute or relative fashion, to what extent they reflect objective or subjective time and whether they are influenced by temporal context. Here we asked human participants to reproduce the durations of sounds in two, partially overlapping, temporal contexts while we record high-spatial resolution fMRI. Both model-based and data driven analyses show the presence of auditory chronomaps in the auditory parabelt, intraparietal sulcus, and in supplementary motor area. Most importantly, when the same physical duration is presented in different temporal contexts, and thus perceived differently, different neuronal units respond to it. Those units are also spatially shifted according to the relative position of the perceived duration within each context. Finally, the pattern of activity is more similar within rather than across contexts suggesting their pivotal role in shaping the maps. These results highlight two important properties of chronomaps: their flexibility of representation and their dependency on the context.
Hemoglobinopathies by HPLC: A 3 Year Study of 106,277 Cases
Authors: Joshi Amruta , Gohil Sanjay , Saxena Bhavya , Jatale Raj , Chadha Kirti , Haryan Reshma , Patil Priya , Chanekar Milind 
Published: September 2022

Introduction: Hemoglobinopathies and thalassemias are the most common single gene disorders in the world. World Health Organization figures estimate that 5% of the world populations are carriers of a potentially pathological hemoglobin (Hb) gene. The general incidence of thalassemia trait and sickle cell anaemia in India varies between 3-17% and 1-44% respectively3 but because of consanguinity, caste and area endogamy, some communities show a very high incidence, making the disease a major public health problem in our country. Cation exchange high-performance liquid chromatography (CE-HPLC) is one of the best methods for screening, detection, and identification of various hemoglobinopathies.
Material &Method: A retrospective study was carried out from period of 2017 to 2019 with 106277 cases evaluated with an aim to identify various hemoglobinopathies seen in Indian population by high-performance liquid chromatography. Cases outside Indian geographical location were excluded from the study
Result: A total of 18,936(17.82%) cases with abnormal haemoglobin variants was reported in the study with 35 difference variants across India. Northeast India reported maximum abnormal hemoglobinopathies (50.16%). Beta Thalassemia Trait was the most common abnormal variant found.Such a high incidence emphasises premarital and prenatal screening for prevention of dangerous effects of hemoglobinopathies in the population.
Conclusion: CE-HPLC should be used for early detection and proper management of these haemoglobinopathies. The most common hemoglobinopathy observed in our study was Beta thalassemia trait followed by Sickle cell trait and then sickle cell disease. It was also observed that Northeast India had maximum abnormal hemoglobinopathies.
Industrie 4.0 in Transport und Logistik : Enabler, Hürden und Auswirkungen
Authors: Seidler Gerald 
Published: September 2022

Zehn Jahre nach Einführung des Begriffs Industrie 4.0 findet die Digitalisierung weiterhin Einzug in die die Unternehmenswelt. Die Entwicklung automatischer Routenplanung und autonomer Fahrzeuge ist hierbei besonders im Bereich von Transport und Logistik relevant. Dieser Artikel beschäftigt sich mit den Enablern, Hürden und Auswirkungen von Industrie 4.0 in diesem Bereich.
Basierend auf einer im Vorfeld erfolgten Literaturrecherche, bei der fünfzehn mit Industrie 4.0 verbundene Themengebiete identifiziert worden waren, wurde eine Online- Umfrage durchgeführt, mit dem Ziel diese Themengebiete als Enabler, Hürden oder Auswirkungen von Industrie 4.0 im Hinblick auf Transport und Logistik zu kategorisieren.
Anhand einer quantitativen Analyse der 134 Rückmeldungen werden die wesentlichen Resultate, wie die Top-5 Enabler und Hürden, vorgestellt und die Relevanz von ökonomischen Einsparungspotentialen als wesentlicher Einflussfaktor präsentiert. Abschließend werden acht Hypothesen als Ausgangspunkt für weitere aufbauende Forschungsarbeiten abgeleitet.
Quick and concise land boundary mapping using a drone at Villa Buccu, Kerobokan, Badung, Bali
Authors: Yasada Gede , Sutapa Ketut , Setyono Evin Yudhi 
Published: September 2022

The effective measurement and mapping of the land is retrieval of accurate data according to position, in accordance with mapping provisions and efficient in both cost and time. One way that data can be retrieved effectively and efficiently is by using a drone, commonly called an unmanned aerial vehicle (UAV).Drone is a vehicle equipped with a wave control system, precision navigation (Global Positioning System/GPS) and flight control electronics so that it is able to fly according to flight planning (autopilot). This drone makes it possible to track the position and orientation of sensors implemented in local or global coordinate systems. With the drone itself, it saves time because it can have an image of an area. Premark / Ground Control Point (GCP) is a point that is commonly used to improve measurement accuracy in mapping using drones, in this case using the Global Positioning System (GPS) Geodetic / RTK Hi Target tool. Mapping Using Drones was then used by many people, including for the purposes of villa spatial planning, so to support this activity a land boundary mapping was carried out at Villa Buccu, Kerobokan, Badung Bali.
Clinico-angiographic profiles and in-hospital outcomes of non-ST segment elevation myocardial infarction in Kurdistan Region of Iraq
Authors: Mohammad Ameen M , Issa Haval A , Saeed Saad Y 
Published: September 2022

Objectives: This work aimed to study the clinical, angiographic profiles and in-hospital outcomes of NSTEMI cases in Duhok, Iraq.
Methods: This prospective study involved 283 patients with NSTEMI who were admitted to Azadi teaching hospital/Azadi heart center in Duhok, Kurdistan region of Iraq, between 2021 and 2022. The patient's demographic variables, major cardiovascular risk factors (smoking, hypertension, diabetes mellitus, hyperlipidemia and family history of coronary artery disease), clinical presentation, past history of myocardial infarction/ previous percutaneous coronary intervention (PCI) and drug history were collected. The GRACE risk score was calculated for each patient. Patients were followed up regarding the management strategies (whether conservative or invasive approach), and in-hospital complications and outcomes.
Results: The mean GRACE score was 142±26. 70% of cases underwent coronary angiography/ angioplasty, with a mean time to the coronary intervention of 8 days. 17% of the sample had developed different cardiovascular complications, with heart failure being the most common. The mortality rate was 7.4%.
Conclusion: The study demonstrated higher complications and mortality rates, especially among patients with higher GRACE scores, compared to rates found in most available studies, particularly in western countries. This finding could be secondary to a suboptimal coronary intervention for NSTEMI in terms of time to intervention and the proportion of patients who underwent it.
Intención emprendedora en estudiantes de la Universidad Pontificia Bolivariana: exploración de un modelo basado en la teoría del comportamiento planeado
Authors: Sarmiento-Suárez Jaime Enrique , Reyes-Rodríguez Juan Felipe , Ramírez-Montañez Julio César 
Published: September 2022

El propósito del presente artículo fue, mediante un estudio de caso, caracterizar la intención de creación de empresas de los estudiantes de la Universidad Pontificia Bolivariana (UPB) de diferentes sedes (Montería, Palmira, Medellín y Bucaramanga), con el fin de definir estrategias que ayuden a consolidar y fortalecer la ruta de formación, los programas y contenidos académicos y el acompañamiento institucional orientado a la promoción del emprendimiento. Como referente teórico base se partió de la teoría del comportamiento planeado (TCP), en la cual la intención de un comportamiento de interés, como es el emprendedor, está determinada por las actitudes hacia la creación de empresa, las normas subjetivas y el control comportamental percibido. El análisis empírico del estudio se realizó a partir de un enfoque cuantitativo basado en datos de un cuestionario en línea proporcionado a los estudiantes de pregrado de las cuatro sedes de la institución anteriormente mencionadas. A partir de una muestra de 4214 estudiantes matriculados en los distintos programas de estudio, se llevó a cabo un análisis de factores para establecer la estructura de las variables principales del modelo teórico y, adicionalmente, se exploraron otros constructos, tales como oportunidades y recursos del entorno, así como las desventajas y ventajas del emprendimiento. El análisis inferencial incluyó la regresión lineal múltiple para determinar la influencia de los antecedentes de la intención emprendedora y el análisis de varianza para examinar las diferencias entre los distintos constructos con base en grupos de informantes a partir de sus características sociodemográficas. Los resultados validaron la influencia de los tres antecedentes principales de la intención emprendedora de acuerdo con la TCP, así como también la presencia de familiares emprendedores, en particular que el padre sea socio o dueño de empresa. Adicionalmente, la intención emprendedora es influenciada por las oportunidades del entorno y las ventajas del emprendimiento percibidas por los individuos.
Subjetivación, TIC y Educación matemática. Validación de expertos
Authors: Tocarruncho Ramos Adriana Esperanza 
Published: September 2022

La investigación está motivada desde el entramado entre educación y tecnología, que involucra directamente a los actores del proceso como sujetos transformadores y transformados por la escuela y los modos de ser, sentir, pensar y actuar en el mundo, es decir, su subjetividad. La delimitación conceptual se hace a través de autores como Harris (2017), Muñoz (2015) y Weiss (2012), que concluye en la divergencia de subjetividad, mediación tecnológica y educación matemática de manera explícita en el campo de investigación de la educación, por lo que se convierte en una gran oportunidad de visibilizar el contexto dentro de la educación comparada dentro de un enfoque metodológico de tipo etnográfico apoyado en el método Delphi. El sistema categorial como cada uno de los ítems de los instrumentos fueron evaluados por diez expertos usando la escala de Likert, cuyo análisis fue realizado mediante el coeficiente de Kendall y el alfa de Cronbach.
Como principales hallazgos se consolidó el sistema categorial y se validó los instrumentos de recolección de la información que atienden a técnicas como el cuestionario de caracterización, la observación directa y la revisión documental de las evaluaciones de desempeño.
Population Pharmacokinetic Models for Tacrolimus in non-transplant patients: A Systematic Review
Authors: Wang Cheng-Bin , Li Ying , Zhao Mingming , Zhao Li 
Published: September 2022

Several systematic reviews have been published on tacrolimus (TAC)
population pharmacokinetic (PPK) modeling; however, most of them have
focused on the transplant patient population. This study investigated
TAC population pharmacokinetic characteristics in non-transplant
patients through a systematic review of TAC population pharmacokinetic
studies carried out in this patient population, with the aim of
clarifying factors affecting TAC pharmacokinetic behavior and promoting
individualized TAC-based treatment in non-transplant patients. The
Cochrane Library, PubMed, and Embase databases, as well as Chinese
databases (SinoMed, Wanfang, and China National Knowledge
Infrastructure) and related references, were searched using a non-linear
mixed-effects modeling approach, from the time of inception of the
databases to July 2022, to identify TAC population pharmacokinetic
studies modeled in non-transplant patients. Eighteen studies, all from
Asian countries (China and Korea), were included in this study. Of these
studies, 56% and 28% were carried out in pediatric and adult patients,
respectively. Over half of the studies (56%) were conducted in patients
with nephrotic syndrome. Combined medications, body weight, genetic
polymorphisms, and physiological function were the most common
covariates affecting TAC clearance, and variability in the apparent
volume of distribution was largely explained by body weight. In
addition, only 2 studies assessed the developed models through external
evaluation. In non-transplanted patients, factors that affect TAC
pharmacokinetics include combined medications, body weight, genetic
polymorphisms, and physiological function. Recent investigations have
focused mainly on Asian populations, and expanded trials that will use
external evaluations for relevant model assessment are required to
investigate generalizability to other ethnic populations.
Medical Management of Type 2 Diabetes, 8th Edition
Authors: Meneghini Luigi F. 
Published: September 2022

In this new edition of an essential text, diabetes experts define the progressive nature of type 2 diabetes; examine cardiovascular, microvascular, and neurologic complications; describe care methodologies for special situations, such as pregnancy and hospitalization; and illustrate methods of self-education and behavior change. This book will enhance clinical knowledge of type 2 diabetes and bolster the skills necessary to care for patients with diabetes.
The eighth edition features:
Postoperative Sensitivity of Composite Replacement of Amalgam Restoration: A Randomized Clinical Trial
Authors: Rodrigues NS , de Souza LC , Cunha DA , Souza NO , Silva PGB , Santiago SL , Loguercio AD , Silikas N , Saboia VPA 
Published: September 2022

SUMMARYPurposeThis randomized clinical trial aimed to evaluate the postoperative sensitivity of different resin composite/adhesive materials, placed either by an incremental or bulk-fill technique in posterior resin composite replacement of amalgam restorations.Methods and MaterialsA total of 47 patients with good overall health and at least four class I or class II amalgam restorations to be replaced participated in this study. The characteristics of 188 cavities were registered and randomly restored using incremental (Z350XT, 3M) or bulk-fill (Filtek Bulk Fill, 3M; Sonic Fill, Kerr; and Opus Bulk Fill, FGM) technique. The postoperative sensitivity was assessed using a Visual Analog Scale (0–100) after 24 hours, 7 days, and 30 days. Pain scores were temporally analyzed using Friedman test followed by Dunn post hoc test (α=0.05). The frequency of tests was calculated according to the frequency and percentage of the McNemar test.ResultsThe restorative technique and the bulk-fill system used did not affect the postoperative sensitivity, except for Filtek Bulk Fill group, which presented less postoperative sensitivity after 24 hours (p=0.037). Regardless of the restorative material, the postoperative sensitivity decreased after 24 hours, and no differences were found after 7 and 30 days.ConclusionsAfter 1 week, the filling technique and the bulk-fill system have no influence on the postoperative sensitivity.
Effects of a national work hours restriction in a high hours country
Authors: Lee Jieun 
Published: September 2022

Abstract
This paper examines the effect of a new maximum work hour restriction introduced in South Korea in 2018 that limited maximum working hours from 68 h/week to 52 h/week. I use difference-in-differences analysis with continuous treatment measuring the prevalence of those working longer than 52 h/week prior to the policy change across industry-occupation-education groups. I find that the policy reduces work hours while increasing monthly earnings and hourly wages for male full-time workers. However, I find that the policy does not significantly affect total work hours, total employment, and total worker pay at the industry-occupation-education group level.