bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling of Forced and Natural Convection Drying Process of a Coffee Seed
Authors: Duque-Dussán Eduardo , Villada-Dussán Andrés , Roubík Hynek , Banout Jan 
Published: September 2022

HighlightsThe forced and natural convection drying processes of a single coffee grain can be predicted.The moisture distribution profiles depict the drying phenomena and water concentration zones.With accurate predictive drying curves, coffee growers can ensure high-quality coffee beans.Abstract. Different coffee drying technologies face complex tasks in ensuring an acceptable final seed moisture content. This research performed a Finite Element Analysis (FEA) study, simulating a single coffee bean's drying process as a transient mass diffusion model under mechanical and natural convection conditions, so the drying behavior and data of both case scenarios can be foreseen and controlled by a predictive Finite Element Model (FEM). A wet bean was 3D-scanned and digitized as the FEA simulation geometry; the water diffusion between the grain and the atmosphere was defined by a diffusion coefficient subject to the drying air temperature and the grain's moisture content. Three cases were studied: mechanical grain drying at three different temperatures (50, 45, and 40°C) in a forced convection environment; variable natural convection drying under environmental conditions (wet and dry season); and constant natural convection (wet and dry season), including the variation in day/night temperature and relative humidity. The results agree well with the data found in the literature, obtaining the graphical moisture distribution of the phenomena, predictive drying curves, diffusion coefficients, and isotherms. Both simulated drying scenarios provide essential information for coffee growers to improve and control their drying processes, thus obtaining high-quality grains, reducing contamination by microorganisms, and ensuring the integrity of their products. Keywords: Coffea arabica, Coffee Drying, Coffee Seed, Finite Element Model, Moisture Diffusion.
Detection system of the lobster eye telescope with large
field of view
Authors: Chen Yifan , Sun Xiaojin , Li Zhengda , Wang Chengbin , Zhang Chen , Sun Shengli 
Published: September 2022

The lobster eye telescope is promising for large-field x ray imaging in
astronomy. The special structure of the lobster eye system makes the
focal plane a sphere, resulting in detector defocus when the field is
large. In this study, we established a model based on the principle of
lobster eye imaging and simulated the imaging at different image
distances. The results reveal the relationship between the defocus and
position accuracy and angular resolution. To ensure the optical
performance of the large field lobster eye telescope, we propose a
detection system design method using multiple detectors stitched
together to form a spherical-like surface and apply it to the
development of the Einstein Probe/wide-field x ray telescope (EP/WXT)
submodule. About 70% of the detection area is out of focus within
0.5 mm. The scanning image of the integrated WXT submodule shows good
uniformity of the point spread function (PSF) for various incident
angles, and the effect of defocus on imaging is acceptable.
An extragradient inertial algorithm for solving split fixed-point problems of demicontractive mappings, with equilibrium and variational inequality problems
Authors: Okeke Chibueze C. , Ugwunnadi Godwin C. , Jolaoso Lateef O. 
Published: September 2022

Abstract
The purpose of this article is to study and analyse a new extragradient-type algorithm with an inertial extrapolation step for solving split fixed-point problems for demicontractive mapping, equilibrium problem, and pseudomonotone variational inequality problem in real Hilbert spaces. One of the advantages of the proposed algorithm is that a strong convergence result is achieved without a prior estimate of the Lipschitz constant of the cost operator, which is very difficult to find. In addition, the stepsize is generated at each iteration by some simple computations, which allows it to be easily implemented without the prior knowledge of the Lipschitz constant of the cost operator. Some numerical experiments are reported to show the performance and behaviour of the sequence generated by our algorithm. The obtained results in this article extend and improve many related recent results in this direction in the literature.
Prosodic markers of satirical imitation
Authors: Leymann Saskia , Lentz Tomas O. , Burgers Christian 
Published: September 2022

Abstract
Satirical imitation is a popular format of late-night comedy shows and can provide political entertainment and education. However, little research has been conducted on how satirists mark their satirical intent to clue audiences in on their intended messaging. This study investigates the prosodic marking of satirical imitation and contrasts it with prosodic marking of irony. We conducted a detailed case study of the prosodic marking in Alec Baldwin’s satirical imitation of Donald Trump in his audiobook You Can’t Spell America Without Me contrasted with both Baldwin’s and Trump’s regular voices. The analyzed corpus contained six hours of audio material across the three sources. Through a combination of automatic and manual coding, we measured average pitch, pitch variation, and speech rate. Our analysis did not reveal marking of satirical imitation by pitch or pitch variation. The satirical imitation was only marked by a faster speech rate than both baseline voices. These findings contrast with previous studies that identified a lower pitch, less pitch variation, and a slower speech rate as markers of verbal irony. Our study provides first evidence that satirical imitation is prosodically marked differently from verbal irony, with a faster speech rate as one potential marker.
An extensive review of state-of-the-art transfer learning techniques used in medical imaging: Open issues and challenges
Authors: Mukhlif Abdulrahman Abbas , Al-Khateeb Belal , Mohammed Mazin Abed 
Published: September 2022

Abstract
Deep learning techniques, which use a massive technology known as convolutional neural networks, have shown excellent results in a variety of areas, including image processing and interpretation. However, as the depth of these networks grows, so does the demand for a large amount of labeled data required to train these networks. In particular, the medical field suffers from a lack of images because the procedure for obtaining labeled medical images in the healthcare field is difficult, expensive, and requires specialized expertise to add labels to images. Moreover, the process may be prone to errors and time-consuming. Current research has revealed transfer learning as a viable solution to this problem. Transfer learning allows us to transfer knowledge gained from a previous process to improve and tackle a new problem. This study aims to conduct a comprehensive survey of recent studies that dealt with solving this problem and the most important metrics used to evaluate these methods. In addition, this study identifies problems in transfer learning techniques and highlights the problems of the medical dataset and potential problems that can be addressed in future research. According to our review, many researchers use pre-trained models on the Imagenet dataset (VGG16, ResNet, Inception v3) in many applications such as skin cancer, breast cancer, and diabetic retinopathy classification tasks. These techniques require further investigation of these models, due to training them on natural, non-medical images. In addition, many researchers use data augmentation techniques to expand their dataset and avoid overfitting. However, not enough studies have shown the effect of performance with or without data augmentation. Accuracy, recall, precision, F1 score, receiver operator characteristic curve, and area under the curve (AUC) were the most widely used measures in these studies. Furthermore, we identified problems in the datasets for melanoma and breast cancer and suggested corresponding solutions.
Crystal structure of (E)-N′-(2-chloro-6-hydroxybenzylidene)-4- hydroxybenzohydrazide-water (1/1), C14H13Cl1N2O4
Authors: Liu Kun , Han Qiang , Zhao Kai-Hui , Zhong Qi-Di , Zhang Zhi-Fei 
Published: September 2022

Abstract
C14H13Cl1N2O4, monoclinic, I2/a (no. 15), a = 13.257(5) Å, b = 16.161(4) Å, c = 13.262(3) Å, β = 97.47(3)°, V = 2817.2(14) Å3, Z = 8, R

gt
(F) = 0.0578, wR

ref
(F
2) = 0.1714, T = 293 K.
Pain sensitivity in relation to frequency of migraine and tension-type headache with or without coexistent neck pain: an exploratory secondary analysis of the population study
Authors: Ashina Sait , Bendtsen Lars , Burstein Rami , Iljazi Afrim , Jensen Rigmor Hoejland , Lipton Richard B. 
Published: September 2022

Abstract

Objectives
We aimed to investigate whether coexistent self-reported neck pain influences cephalic and extracephalic pain sensitivity in individuals with migraine and tension-type headache (TTH) in relation to diagnosis and headache frequency.

Methods
A population of 496 individuals completed a headache interview based on ICHD criteria, providing data collected by self-administered questionnaires, assessments of pericranial total tenderness score (TTS) and pressure pain thresholds (PPT). Stimulus-response (SR) functions for pressure vs. pain were recorded. Presence of neck pain in the past year was assessed by the self-administered questionnaire. We categorized participants by primary headache type. We also categorized participants into 3 groups by headache frequency: chronic (≥15) or episodic (<15 headache days/month) headache and controls. TTS, PPTs and the area under the SR curve were compared between subgroups using Generalized Linear Models with pairwise comparisons controlling for age and sex.

Results
Individuals with chronic followed by episodic headache had higher TTS than controls (overall p≤0.001). The difference between chronic and episodic headache subgroups was significant in the group with neck pain (p≤0.001) but not in the group without neck pain. In individuals with neck pain, mean TTS was higher in coexistent headache (migraine and TTH), 23.2 ± 10.7, and pure TTH, 17.8 ± 10.3, compared to pure migraine, 15.9 ± 10.9 and no headache 11.0 ± 8.3 (overall p<0.001). Temporal and finger PPTs did not statistically differ among the chronic headache, the episodic headache and controls in individuals with and without neck pain. Temporalis and trapezius SR-functions showed that tenderness was increased in individuals with chronic headache to higher degree than in those with episodic headache, and more so in those with neck pain.

Conclusions
Coexistent neck pain is associated with greater pericranial tenderness in individuals with chronic headache and to a lesser degree in those with episodic headache. Sensitization may be a substrate or consequence of neck pain and primary headache, but a longitudinal study would be needed for further clarification.
Ablaufoptimierung in einer Halbleiterfertigung
Authors: Schneidewind Jan , Lorenz Björn 
Published: September 2022

AbstractBei der Ablaufplanung automatisierter Anlagen wird häufig ein regelbasiertes, iteratives Verfahren angewandt. In dieser Studie wird am Beispiel einer Nassbank aus der Halbleiterindustrie gezeigt, welches Potenzial dadurch verloren geht und wie die Ablaufplanung optimiert werden kann. Des Weiteren wird untersucht, wie sich durch Anpassungen am Aufbau der Anlage die durchschnittliche Durchlaufzeit noch weiter reduzieren lässt.
Disposal Date Calculator for Radioactive Material
Authors: Rodrigues Junior Ary de Araujo 
Published: September 2022

A computer program in PHP was developed to become easier the disposal calculus for radioactive material of low and medium radiation levels according to CNEN-801 (Low and medium radiation level waste management). The user selects some inputs as: the radionuclide name, its physical state, activity and obtains among others outputs: the number of days for disposal and disposal date. There is an option for calculation without considering the radionuclide where the parameters are only the half-life, initial and disposal activity. It can be accessed by the Internet or downloaded from a repository to be installed on the users computer or server. The program language can be chosen between Portuguese and English.
Critical Velocity Experimental Assessment in Flat Plate Fuel Element for Nuclear Research Reactor
Authors: Andrade Delvonei Alves , Gonzalez Mantecón Javier , Navarro de Mesquita Roberto , Mattar Neto Miguel , Ernesto Umbehaun Pedro , Maximo Torres Walmir 
Published: September 2022

Aluminum-coated plates, containing a uranium silicide (U3Si2) meat dispersed in an aluminum matrix, are commonly used in the fuel elements of Material Testing Reactors (MTRs). These fuel elements are typically comprised of narrow channels formed by parallel flat plates, which allow coolant flow to remove the heat of fission reactions. It is important to mention that the thickness of the plates is much smaller than their width and height. The high flow rates needed to ensure efficient fuel-element cooling may cause fuel-plate mechanical failures due to instability induced by the flow in the channels. In the case of critical velocity, excessive permanent deflections of these plates can cause blockage of the flow channels and lead to overheating. An experimental facility that simulates a plate-like fuel element with three coolant channels was developed for this work. The test-section dimensions were based on the Fuel Element design of the Brazilian Multipurpose Reactor (RMB), project being coordinated by the National Commission of Nuclear Energy (CNEN). Experiments were performed to reach Miller's critical velocity condition. This critical condition was reached at 14.5 m/s leading to consequent plastic deformation of the fuel plates
Workplace radiation dose monitoring in diagnostic radiography Centres of the Lake Zone Regions of Tanzania
Authors: Ngulimi Miguta Faustine , Mwimanzi Jerome Mbwilo , Ndovi Siwidhani Thomas 
Published: September 2022

Occupational radiation doses in diagnostic radiography Centres of the Lake Zone Regions of Tanzania were measured and analyzed. Thermoluminiscent Dosimeters (TLDs) were distributed to 17 radiation workers from 8 selected medical centres over a period of three (3) months. The estimated ambient doses in the Centers was measured by using a calibrated survey meter RAM DA-3-2000 of TAEC under SSDL Laboratory. The individual dose recorded ranged from 0.09 to 1.12 mSv which were all below the ICRP limit of 5mSv for 3 months. The radiation dose (ambient) recorded at 1 m from the control lead glass window ranged from 2.15 µSv/h to 7.27 µSv/h. The ambient doses were compared to the limit of 7.5 µSv/h set by ICRP. Higher values of ambient doses and indivudual doses were observed in some centres which entails improper radiation safety and protection measures in radiation cantres. But with the use of protective gears, radiation workers receive lower doses hence abide with ALARA principle.
Crack propagation resistance of TiAl alloys
Authors: Pippan R. , Hohenwarter A. 
Published: September 2022

AbstractIn their temperature window of application, TiAl alloys typically fail in a semi-brittle manner. For this material class, the Griffith concept, developed initially for ideal brittle materials, has to be adapted by additional dissipative contributions to the fracture resistance: plastic deformation, crack bridging, the work to deform and fracture shear ledges, and crack bifurcation. These additional terms in the fracture resistance induce a pronounced R-curve effect or in other words, a crack extension-dependent fracture resistance for monotonic and cyclic loading. In order to deliver guidelines to optimize the microstructural design and to enhance the fracture resistance of TiAl alloys, model systems, including a polysynthetically twinned TiAl, a designed fully lamellar and a near-gamma TiAl alloy are discussed in terms of their fracture mechanism using the energy and stress intensity approach.
Graphical abstract
Nephrotic Syndrome Gene TBC1D8B Is Required for Endosomal Maturation and Nephrin Endocytosis in Drosophila
Authors: Milosavljevic Julian , Lempicki Camille , Lang Konrad , Heinkele Helena , Kampf Lina L. , Leroy Claire , Chen Mengmeng , Gerstner Lea , Spitz Dominik , Wang Minxian , Knob Andrea U. , Kayser Séverine , Helmstädter Martin , Walz Gerd , Pollak Martin R. , Hermle Tobias 
Published: September 2022

Significance Statement
Variants in TBC1D8B cause isolated nephrotic syndrome. TBC1D8B protein interacts with the slit diaphragm protein nephrin, but the pathogenesis remains unclear. We used Drosophila to elucidate the functional role of the recently discovered disease-causing gene. A null allele of Tbc1d8b in Drosophila exhibits a nephrocyte-restricted phenotype similar to patient presentation. Tbc1d8b protein localizes to mature early and late endosomes and promotes endosomal maturation and degradation, and is further required for nephrin transport. Expression of the murine ortholog rescues loss-of-function of the Drosophila TBC1D8B, which indicates evolutionary conservation. Discovery of two novel variants in TBC1D8B in a cohort of 363 patients with FSGS and functional validation in Drosophila suggest that TBC1D8B variants significantly underlie hereditary FSGS.

Background
Variants in TBC1D8B cause nephrotic syndrome. TBC1D8B is a GTPase-activating protein for Rab11 (RAB11-GAP) that interacts with nephrin, but how it controls nephrin trafficking or other podocyte functions remains unclear.

Methods
We generated a stable deletion in Tbc1d8b and used microhomology-mediated end-joining for genome editing. Ex vivo functional assays utilized slit diaphragms in podocyte-like Drosophila nephrocytes. Manipulation of endocytic regulators and transgenesis of murine Tbc1d8b provided a comprehensive functional analysis of Tbc1d8b.

Results
A null allele of Drosophila TBC1D8B exhibited a nephrocyte-restricted phenotype of nephrin mislocalization, similar to patients with isolated nephrotic syndrome who have variants in the gene. The protein was required for rapid nephrin turnover in nephrocytes and for endocytosis of nephrin induced by excessive Rab5 activity. The protein expressed from the Tbc1d8b locus bearing the edited tag predominantly localized to mature early and late endosomes. Tbc1d8b was required for endocytic cargo processing and degradation. Silencing Hrs, a regulator of endosomal maturation, phenocopied loss of Tbc1d8b. Low-level expression of murine TBC1D8B rescued loss of the Drosophila gene, indicating evolutionary conservation. Excessive murine TBC1D8B selectively disturbed nephrin dynamics. Finally, we discovered four novel TBC1D8B variants within a cohort of 363 patients with FSGS and validated a functional effect of two variants in Drosophila, suggesting a personalized platform for TBC1D8B-associated FSGS.

Conclusions
Variants in TBC1D8B are not infrequent among patients with FSGS. TBC1D8B, functioning in endosomal maturation and degradation, is essential for nephrin trafficking.
Battling statues enter into dialogue at the Gouvernorat du Haut-Katanga
Authors: Kapanga Kasongo Mulenda 
Published: September 2022

In this article I analyze the political bifocal discourse that the display of Congolese political figures reveals at the Gouvernorat du Haut-Katanga (State House of the Province of Haut-Katanga) in Lubumbashi, Democratic Republic of the Congo that was inaugurated in 2018. The display reflects the potency of a discourse dictated by a period of time’s circumstances reflective of new ways of thinking. It is the performative self-affirmation focusing on the politics of proximity and not exclusively that of distanciation seen in its worst form in ethnic cleansing. Within the global atmosphere marked by public demonstrations heightened by the death of George Floyd (1973–2020) calling for the toppling of monuments honoring Robert E. Lee; Cecil Rhodes; George Colston’s in Bristol, England; King Leopold II in Belgium; honoring busts of King Leopold next to Doňa Beatriz Kimpa Vita’s; and Moïse Tshombe’s next to Patrice-Emery Lumumba’s, inevitably leads observers to question the arrangement. It articulates in plain sight a twofold political discourse positing, on one hand, its unitary aspiration, on the other hand, the uniqueness of the Katanga province with its strengths, its expectations, and its vulnerabilities. My analysis relies on Michel Foucault’s concept of discourse, on Pierre Nora’s notion of lieux de mémoire, and François Hartog’s idea of presentism. Hartog’s presentism accommodates an analytical exercise that uncovers a discourse of continuity allowed by the necessities of the present. Specific discursive elements become building blocks towards the aspiration to social stability reflected and re-articulated throughout the materiality and rationalizing of figural representations.
An integrated computational study for screening medicinal plant phytochemicals for possible inhibitors of the human bile salt exporter pump
Authors: Alshehri Dhafer B. 
Published: September 2022

Background: The primary carrier of bile acids in humans is the bile salt export pump (BSEP). which are crucial for the digestion and absorption of fat. Type 2 progressive familial intrahepatic cholestasis (PFIC-2), which is brought on when BSEP is suppressed and causes a decrease in bile flow and a buildup of cytotoxic bile salts in the liver, is one of the main causes of cholestasis in Saudi Arabia. Elucidate the inhibitory potential with minimal or no adverse effects.Methods: The structure (6LR0) was downloaded from the PDB. Protein active sites were anticipated because these are pockets where ligands can bind and perform reactions to treat an infection. The PubChem zinc and mpd3 databases were used to get the ligands' structures. Molecular operating environment (MOE) was utilized to perform molecular docking of 1600 phytochemicals against BSEP. LigX was used to observe the docking hits for interaction analysis. Results: identification of 4 potential candidates for binding to the BSEP active site. then, Protox II-was used to forecast toxicity for the selected hits. Molecular dynamics simulations were also used to assess the binding complex's stability in water for 100 nanoseconds. The strong binding affinity of high-ranked drugs was predicted by our molecular docking and simulation.Conclusions: This approach could be useful in determining the efficiency of a therapeutic molecule in the therapy of the BSEP. The aim of this research is to identify novel -BSEP drug targets, and in future in vitro and in vivo research could prove its clinical efficiency.