bluuebunny/crossref_metadata_2025_split huggingface dataset:
JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study
Authors: Liberale Luca , Puspitasari Yustina M , Ministrini Stefano , Akhmedov Alexander , Kraler Simon , Bonetti Nicole R , Beer Georgia , Vukolic Ana , Bongiovanni Dario , Han Jiaying , Kirmes Kilian , Bernlochner Isabell , Pelisek Jaroslav , Beer Jürg H , Jin Zheng-Gen , Pedicino Daniela , Liuzzo Giovanna , Stellos Konstantinos , Montecucco Fabrizio , Crea Filippo , Lüscher Thomas F , Camici Giovanni G 
Published: December 2022

Abstract

Aims
Variants of the junctional cadherin 5 associated (JCAD) locus associate with acute coronary syndromes. JCAD promotes experimental atherosclerosis through the large tumor suppressor kinase 2 (LATS2)/Hippo pathway. This study investigates the role of JCAD in arterial thrombosis.

Methods and results
JCAD knockout (Jcad−/−) mice underwent photochemically induced endothelial injury to trigger arterial thrombosis. Primary human aortic endothelial cells (HAECs) treated with JCAD small interfering RNA (siJCAD), LATS2 small interfering RNA (siLATS2) or control siRNA (siSCR) were employed for in vitro assays. Plasma JCAD was measured in patients with chronic coronary syndrome or ST-elevation myocardial infarction (STEMI). Jcad−/− mice displayed reduced thrombogenicity as reflected by delayed time to carotid occlusion. Mechanisms include reduced activation of the coagulation cascade [reduced tissue factor (TF) expression and activity] and increased fibrinolysis [higher thrombus embolization episodes and D-dimer levels, reduced vascular plasminogen activator inhibitor (PAI)-1 expression]. In vitro, JCAD silencing inhibited TF and PAI-1 expression in HAECs. JCAD-silenced HAECs (siJCAD) displayed increased levels of LATS2 kinase. Yet, double JCAD and LATS2 silencing did not restore the control phenotype. si-JCAD HAECs showed increased levels of phosphoinositide 3-kinases (PI3K)/ proteinkinase B (Akt) activation, known to downregulate procoagulant expression. The PI3K/Akt pathway inhibitor—wortmannin—prevented the effect of JCAD silencing on TF and PAI-1, indicating a causative role. Also, co-immunoprecipitation unveiled a direct interaction between JCAD and Akt. Confirming in vitro findings, PI3K/Akt and P-yes-associated protein levels were higher in Jcad−/− animals. Lastly, as compared with chronic coronary syndrome, STEMI patients showed higher plasma JCAD, which notably correlated positively with both TF and PAI-1 levels.

Conclusions
JCAD promotes arterial thrombosis by modulating coagulation and fibrinolysis. Herein, reported translational data suggest JCAD as a potential therapeutic target for atherothrombosis.
Strategic joining rules in unobservable queues with dynamic service rate
Authors: Ma Shuangfeng , Guo Wei 
Published: December 2022

Abstract
This paper considers an unobservable queue with adjustable service rate and strategic customers. A queueing-game-theoretic model is built to capture the interaction between the server’s service rate and customers’ joining decisions. Iterative and recursive methods are used to derive the steady-state distribution and the expected sojourn time in the queue. We obtain customers’ equilibrium and socially optimal joining strategies under two information scenarios which are unobservable and partially unobservable queues, separately. It is found that there are four equilibrium joining strategies at most in the fully unobservable queue and two equilibrium joining strategies in the almost unobservable queue. Interestingly, the social optimal arrival rate is between the minimum and maximum stable equilibria. Thus, in most cases, managers need to charge a price to induce the social optimal customers’ behaviour. However, if the minimum equilibrium is achieved, managers are required to provide a subsidy to maximize the social welfare. unobservable queue; $(m, N)$ policy; equilibrium strategy; social welfare.
Efficacy of an mHealth self-management intervention for persons living with HIV: the WiseApp randomized clinical trial
Authors: Schnall Rebecca , Sanabria Gabriella , Jia Haomiao , Cho Hwayoung , Bushover Brady , Reynolds Nancy R , Gradilla Melissa , Mohr David C , Ganzhorn Sarah , Olender Susan 
Published: December 2022

AbstractImportanceProgression of HIV disease, the transmission of the disease, and premature deaths among persons living with HIV (PLWH) have been attributed foremost to poor adherence to HIV medications. mHealth tools can be used to improve antiretroviral therapy (ART) adherence in PLWH and have the potential to improve therapeutic success.ObjectiveTo determine the efficacy of WiseApp, a user-centered design mHealth intervention to improve ART adherence and viral suppression in PLWH.Design, Setting, and ParticipantsA randomized (1:1) controlled efficacy trial of the WiseApp intervention arm (n = 99) versus an attention control intervention arm (n = 101) among persons living with HIV who reported poor adherence to their treatment regimen and living in New York City.InterventionsThe WiseApp intervention includes the following components: testimonials of lived experiences, push-notification reminders, medication trackers, health surveys, chat rooms, and a “To-Do” list outlining tasks for the day. Both study arms also received the CleverCap pill bottle, with only the intervention group linking the pill bottle to WiseApp.ResultsWe found a significant improvement in ART adherence in the intervention arm compared to the attention control arm from day 1 (69.7% vs 48.3%, OR = 2.5, 95% CI 1.4–3.5, P = .002) to day 59 (51.2% vs 37.2%, OR = 1.77, 95% CI 1.0–1.6, P = .05) of the study period. From day 60 to 120, the intervention arm had higher adherence rates, but the difference was not significant. In the secondary analyses, no difference in change from baseline to 3 or 6 months between the 2 arms was observed for all secondary outcomes.ConclusionsThe WiseApp intervention initially improved ART adherence but did not have a sustained effect on outcomes.
The One-Man Show: The Effect of Joint Decision-Making on Investor Overconfidence
Authors: Piehlmaier Dominik M 
Published: December 2022

AbstractThis study examines the impact of shared decision-making on investor overconfidence. Data from 2,000 investors, 6,394 consumers, and 657 experimental participants shed light on whether consumers who engage in joint financial decision-making are less affected by investor overconfidence than those who decide on their own. The findings show that investors who jointly decide are substantially less overconfident. However, family- or friend-inclined interactions are more effective in reducing overconfidence than relying on a financial advisor. The current research theoretically argues and empirically shows that shared metaknowledge drives this diminishing effect by highlighting unknown aspects of a financial decision. Compared to providing investors with solutions, problem reformulation, validation, or legitimation, only metaknowledge consistently decreases overconfidence in joint financial decision-making. It is argued that the process of highlighting unknowns can explain why interactions with family and friends have a more pronounced impact on investor overconfidence than consulting a professional advisor. The study provides a feasible debiasing tool to consumers, financial institutions, and other financial service providers to decrease overconfidence by emphasizing unknown aspects of an investment toward improving the quality of a consumer’s financial decisions under uncertainty.
Temporal occurrence of three blue whale populations in New Zealand waters from passive acoustic monitoring
Authors: Barlow Dawn R , Klinck Holger , Ponirakis Dimitri , Holt Colberg Mattea , Torres Leigh G 
Published: December 2022

AbstractDescribing spatial and temporal occurrence patterns of wild animal populations is important for understanding their evolutionary trajectories, population connectivity, and ecological niche specialization, with relevance for effective management. Throughout the world, blue whales produce stereotyped songs that enable identification of separate acoustic populations. We harnessed continuous acoustic recordings from five hydrophones deployed in the South Taranaki Bight (STB) region of Aotearoa New Zealand from January 2016 to February 2018. We examined hourly presence of songs from three different blue whale populations to investigate their contrasting ecological use of New Zealand waters. The New Zealand song was detected year-round with a seasonal cycle in intensity (peak February–July), demonstrating the importance of the region to the New Zealand population as both a foraging ground and potential breeding area. The Antarctic song was present in two distinct peaks each year (June–July; September–October) and predominantly at the offshore recording locations, suggesting northbound and southbound migration between feeding and wintering grounds. The Australian song was only detected during a 10-day period in January 2017, implying a rare vagrant occurrence. We therefore infer that the STB region is the primary niche of the New Zealand population, a migratory corridor for the Antarctic population, and outside the typical range of the Australian population.
Review of the Clinical Presentation, Pathology, Diagnosis, and Treatment of Leishmaniasis
Authors: Mathison Blaine A , Bradley Benjamin T 
Published: December 2022

Abstract
Leishmaniasis is a vector-borne infection caused by kinetoplastid protozoans in the genera Leishmania and Endotrypanum. The disease occurs worldwide in the tropics and subtropics and can be particularly burdensome in resource-limited settings. Diseases caused by leishmaniasis range in severity from mild cutaneous lesions to life-threatening visceral and disfiguring mucocutaneous illnesses. Rapid and accurate diagnosis is needed to ensure proper clinical management of patients afflicted with this disease. Complicating matters of diagnosis and treatment are the diversity of species within these 2 genera and the variable specificity of diagnostic assays. This mini-review provides laboratory professionals with an overview of Leishmania epidemiology, biology, pathogenesis, clinical presentations, and treatments with additional emphasis placed on the nuances involved in diagnosis.
First discovery of quasi-periodic oscillations in the dwarf nova HS 2325+8205 based on TESS photometry
Authors: Sun Qi-Bin , Qian Sheng-Bang , Zhu Li-Ying , Dong Ai-Jun , Zhi Qi-Jun , Liao Wen-Ping , Zhao Er-Gang , Han Zhong-Tao , Liu Wei , Zang Lei , Li Fu-Xing , Shi Xiang-Dong 
Published: December 2022

ABSTRACT
HS 2325+8205 is a long-period eclipsing dwarf nova with an orbital period above the period gap (Porb &gt; 3 h) and is reported to be a Z Cam-type dwarf nova. We study the light variation and the quasi-periodic oscillations (QPOs) of HS 2325+8205 based on the photometry of theTransiting Exoplanet Survey Satellite (TESS). Using a continuous wavelet transform, a Lomb–Scargle periodogram (LSP), and sine fitting methods, we find for the first time that there is a QPO of ∼2160 s in the long outburst top light curves of HS 2325+8205. Moreover, we find that the oscillation intensity of the QPOs of HS 2325+8205 is related to the orbital phase, and the intensity in orbital phases 0.5–0.9 is stronger than in orbital phases 0.1–0.5. Therefore, the relationship between the oscillation intensity of QPOs and the orbital phase may become a topic of research into the origin of QPOs. In addition, we use the LSP to correct the orbital period of HS 2325+8205 to 0.19433475(6) d.
The effect of linear background rotational flows on magnetoacoustic modes of a photospheric magnetic flux tube
Authors: Skirvin S J , Fedun V , Silva S S A , Van Doorsselaere T , Claes N , Goossens M , Verth G 
Published: December 2022

ABSTRACT
Magnetoacoustic waves in solar magnetic flux tubes may be affected by the presence of background rotational flows. Here, we investigate the behaviour of m = 0 and m = ±1 modes of a magnetic flux tube in the presence of linear background rotational flows embedded in a photospheric environment. We show that the inclusion of a background rotational flow is found to have little effect on the obtained eigensolutions for the axisymmetric m = 0 sausage mode. However, solutions for the kink mode are dependent on the location of the flow resonance modified by the slow frequency. A background rotational flow causes the modified flow resonances to possess faster phase speeds in the thin-tube (TT) limit for the case m = 1. This results in solutions for the slow body and slow surface kink modes to follow this trajectory, changing their dispersive behaviour. For a photospheric flux tube in the TT limit, we show that it becomes difficult to distinguish between the slow surface and fast surface kink (m = 1) modes upon comparison of their eigenfunctions. 2D velocity field plots demonstrate how these waves, in the presence of background rotational flows, may appear in observational data. For slow body kink modes, a swirling pattern can be seen in the total pressure perturbation. Furthermore, the tube boundary undergoes a helical motion from the breaking of azimuthal symmetry, where the m = 1 and m = −1 modes become out of phase, suggesting the resulting kink wave is circularly polarized. These results may have implications for the seismology of magnetohydrodynamic waves in solar magnetic vortices.
Epistatic Effects Between Amino Acid Insertions and Substitutions Mediate Toxin resistance of Vertebrate Na+,K+-ATPases
Authors: Mohammadi Shabnam , Özdemir Halil İbrahim , Ozbek Pemra , Sumbul Fidan , Stiller Josefin , Deng Yuan , Crawford Andrew J , Rowland Hannah M , Storz Jay F , Andolfatto Peter , Dobler Susanne 
Published: December 2022

AbstractThe recurrent evolution of resistance to cardiotonic steroids (CTS) across diverse animals most frequently involves convergent amino acid substitutions in the H1-H2 extracellular loop of Na+,K+-ATPase (NKA). Previous work revealed that hystricognath rodents (e.g., chinchilla) and pterocliform birds (sandgrouse) have convergently evolved amino acid insertions in the H1-H2 loop, but their functional significance was not known. Using protein engineering, we show that these insertions have distinct effects on CTS resistance in homologs of each of the two species that strongly depend on intramolecular interactions with other residues. Removing the insertion in the chinchilla NKA unexpectedly increases CTS resistance and decreases NKA activity. In the sandgrouse NKA, the amino acid insertion and substitution Q111R both contribute to an augmented CTS resistance without compromising ATPase activity levels. Molecular docking simulations provide additional insight into the biophysical mechanisms responsible for the context-specific mutational effects on CTS insensitivity of the enzyme. Our results highlight the diversity of genetic substrates that underlie CTS insensitivity in vertebrate NKA and reveal how amino acid insertions can alter the phenotypic effects of point mutations at key sites in the same protein domain.
Autoantibodies in lupus nephritis useful in distinguishing proliferative nephritis from membranous nephritis
Authors: Asanuma Yuko , Nozawa Kazuhisa , Matsushita Masakazu , Kusaoi Makio , Abe Yoshiyuki , Yamaji Ken , Tamura Naoto 
Published: December 2022

ABSTRACT

Objectives
This study was conducted to determine autoantibodies associated with lupus nephritis (LN), especially those useful in diagnosing proliferative and membranous nephritis.

Methods
A total of 106 patients with LN and 63 patients with systemic lupus erythematosus but no nephritis were enrolled; then, 55 patients were selected from the LN group and were divided into two groups: proliferative nephritis patients (n = 36) and membranous nephritis patients (n = 19). The autoantibody profiles of patients’ sera were evaluated using the EUROLINE ANA Profile 3 (IgG) kit.

Results
A higher positivity rate of anti-double-stranded DNA antibody and anti-histone antibody was seen in LN patients compared to nonrenal systemic lupus erythematosus patients. In comparing between proliferative and membranous nephritis, the positivity of anti-nucleosome antibody was higher in proliferative nephritis, although it was not statistically significant. However, anti-nucleosome antibody–positive patients with LN had a higher prevalence of haematuria and pyuria, which are strong indications of proliferative nephritis. Also, a significantly higher positivity rate of anti-RNP70 antibody was seen in membranous nephritis compared to proliferative nephritis.

Conclusions
Our results showed that anti-nucleosome and anti-RNP70 antibodies may be predictive nonhistological factors for discriminating between proliferative and membranous LN.
Post-Collisional Silica-Undersaturated Bamaoqiongzong Volcanic Rocks from Northern Qiangtang: Indicators of the Mantle Heterogeneity and Geodynamic Evolution of Central Tibet
Authors: Qi Yue , Wang Qiang , Wei Gang-Jian , Wyman Derek A , Zhang Xiu-Zheng , Dan Wei , Zhang Le , Yang Ya-Nan 
Published: December 2022

AbstractThe formation of post-collisional mantle-derived rocks in the Tibetan Plateau has been linked to the deep geodynamic processes that cause surface uplift. Co-existing silica-oversaturated to silica-undersaturated mantle-derived rocks have been identified in the northern Qiangtang Terrane (NQT). However, the origins of silica-undersaturated magmas are controversial, and the mechanisms responsible for variable silica activity in the mantle-derived rocks are unclear. Here, we present 40Ar/39Ar chronology, mineral chemistry, and whole-rock geochemical data for the Bamaoqiongzong (BMQZ) volcanic rocks of the NQT. The BMQZ volcanic rocks consist of olivine leucitites, trachybasalts, and phonolites and were erupted at ca. 29 Ma. All samples are unsaturated in silica and characterized by enrichment in light rare earth elements and large-ion lithophile elements, depletion in high-field-strength elements, and the presence of negative Nb–Ta–Ti anomalies and positive Pb anomalies. All samples show limited variation in (87Sr/86Sr)i (0.7079–0.7085) and εNd(t) values (−6.9 to −5.3). The geochemical compositions of the BMQZ volcanic rocks indicate that they were produced by partial melting of carbonated phlogopite–lherzolite within the lithospheric mantle. The formation of the olivine leucitites-trachybasalts-phonolites suite was controlled by fractional crystallization and magma mixing in a magmatic plumbing system. This plumbing system included several independent reservoirs and conduits within the crust. The enriched mantle sources of the BMQZ volcanic rocks were formed by the addition of carbonate-rich melts released from the southward-subducted Songpan–Ganzi Terrane after the Late Cretaceous. Our new results, together with published data, reveal systematic variations in geochemical compositions between silica-undersaturated and silica-oversaturated rocks in the NQT, which are ascribed to variations in the nature of the subducted continental materials added during intracontinental subduction. Carbonate-rich melts that were formed by the breakdown of carbonate minerals helped to generate the mantle sources of silica-undersaturated rocks, whereas silicate melts produced by the partial melting of sediment diapirs contributed to the generation of the silica-oversaturated rocks. On the basis of published numerical modelling of continental subduction and crustal deformation records in the NQT, we suggest that intracontinental subduction and lithospheric thinning together contributed to the generation of post-collisional mantle-derived rocks in the Tibetan Plateau.
A contribution to the mathematical theory of diffraction: a note on double Fourier integrals
Authors: Assier R C , Shanin A V , Korolkov A I 
Published: December 2022

Summary
We consider a large class of physical fields $u$ written as double inverse Fourier transforms of some functions $F$ of two complex variables. Such integrals occur very often in practice, especially in diffraction theory. Our aim is to provide a closed-form far-field asymptotic expansion of $u$. In order to do so, we need to generalise the well-established complex analysis notion of contour indentation to integrals of functions of two complex variables. It is done by introducing the so-called bridge and arrow notation. Thanks to another integration surface deformation, we show that, to achieve our aim, we only need to study a finite number of real points in the Fourier space: the contributing points. This result is called the locality principle. We provide an extensive set of results allowing one to decide whether a point is contributing or not. Moreover, to each contributing point, we associate an explicit closed-form far-field asymptotic component of $u$. We conclude the article by validating this theory against full numerical computations for two specific examples.
Adverse Events in the Pediatric Cardiac Catheterization Suite: Does Having Pediatric Cardiac Anesthesiologists Make a Difference?
Authors: Lin Albert Y. , Habib Anthony , Ko Riva , Jerome E. Heidi , Gou Wenhao , Wang Shuang , Sun Lena S. 
Published: December 2022

Introduction:
It has been suggested that anesthesiologists with subspecialty expertise in pediatric cardiac anesthesia are best qualified to care for patients with complex congenital cardiac anomalies and manage the complex physiology frequently encountered in the pediatric cardiac catheterization lab. We evaluated the incidence of adverse events in our pediatric cardiac catheterization lab, comparing care provided by cardiac and noncardiac pediatric attending anesthesiologists.

Methods:
Data were collected on each anesthetic in the pediatric cardiac catheterization lab from January 1, 2016 to December 31, 2019. A generalized linear mixed effect model was used to identify associations between pediatric cardiac and noncardiac anesthesiologists and the presence of adverse events adjusting for age, American Society of Anesthesiologists physical status, emergency status, and interventional versus diagnostic procedures.

Results:
A total of 3,761 procedures involving 1,729 patients were included in the study. There was no significant difference between noncardiac and cardiac anesthesia attendings for overall adverse events (odds ratio [OR], 1.2; 95% confidence interval [CI], 0.82 to 1.75 P=0.349). Specific respiratory adverse events (OR, 1.22; 95%, CI 0.73 to 2.03 P=0.443) or cardiac adverse events (OR, 1.26; 95% CI, 0.64 to 2.48 P=0.502) were also not significantly different with respect to noncardiac compared with cardiac attending anesthesiologists.

Conclusions:
In our analysis, the incidence of adverse events in the pediatric cardiac catheterization lab during the study period was not statistically different, whether anesthesia care was provided by a cardiac or a noncardiac anesthesiologist.