bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Denaturation and Renaturation Kinetics of β-Galactosidase by Chemical Denaturants in The Presence of Galactose, a Product Inhibitor
Authors: Nwamba Okechukwu 
Published: November 2022

In the present report, a quantitative characterization predicting functional allosteric states as a function of chemical denaturants (urea and Guanidine Hydrochloride) and ligand (galactose) concentrations has been presented for β-Galactosidase. The exact calculations predicting the apparent inactivation rate constant, _A_, and the product formed at infinite observable time, [P]∞, both as functions of protein unfolding studies in the presence of ligands are derived with implications of these derivations. These derivations, which are thermodynamic parameters, ultimately represent the apparent rate of enzyme/protein inactivation when an unfolded/unfolding protein interacts with ligand modifiers (_A_ is the rate at which the protein is inactivated under such conditions) and the accompanying [P]∞ which can translate to _Kcat_ (catalytic constant), _Kc_ the_ _enzyme turnover number which can translate – for example – to enzyme shuttling activities across membrane barriers, or even conversion efficiency from one enzyme form to the other on ligand binding to the unfolding/unfolded protein form as a result of allostery. Prior to these derivations, it has been impossible to quantify and characterize allosteric transition conditions via mathematical calculations. Simulation-based multiscale methods have been the way to make rough estimates-in-the-ball-park predictions of allosteric characterizations for quantitative purposes. Even though these derivations were made for β-galactosidase using chemical denaturants as the unfolding agents and galactose as the ligand modifier, it is expected that these equations will cut through different proteins, unfolding conditions, and ligand modifiers.
KARAKTERISTIK FISIK, KIMIA DAN ORGANOLEPTIK KOMBINASI SUSU KEDELAI DAN EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) DALAM PEMBUATAN ES KRIM
Authors: Simanjuntak Ventina , Fortuna Ayu Dewi , Rossi Evy 
Published: November 2022

Es krim adalah salah satu jenis makanan beku yang sangat digemari oleh berbagai jenis kalangan masyarakat. Es krim umumnya dibuat dari bahan dasar susu sapi, namun dewasa ini penggunaan susu sapi sebagai bahan dasar es krim dapat digantikan menjadi susu kedelai. Tujuan penelitian adalah untuk memperoleh kombinasi es krim terbaik dengan menggunakan susu kedelai dan ekstrak kulit buah naga merah. Penelitian ini dilaksanakan secara eksperimen dengan menggunakan Rancangan Acak Lengkap (RAL) dengan lima perlakuan dan tiga kali ulangan. Perlakuan dalam penelitian ini adalah kombinasi susu kedelai: ekstrak kulit buah naga merah, antara lain KN1 (100:0), KN2 (90:10), KN3 (80:20), KN4 (70:30), dan KN5 (60:40). Data yang diperoleh dianalisis secara statistik dengan menggunakan Analysis of Variance (ANOVA) dan uji lanjut Duncan’s Multiple Range Test (DMRT) pada taraf 5%. Penelitian ini menunjukkan bahwa kombinasi susu kedelai dan ekstrak kulit buah naga merah berpengaruh nyata terhadap total padatan, overrun, titik leleh, kadar lemak, kadar protein, aktivitas antioksidan, penilaian uji sensori terhadap warna, aroma, tekstur dan rasa. Perlakuan terpilih yaitu es krim perlakuan KN5 dengan nilai total padatan 36,49%, overrun 46,67%, waktu leleh 26,12 menit, kadar lemak 5,41%, kadar protein 2,19%, dan aktivitas antioksidan 99,11 ppm. Hasil uji deskriptif menunjukkan bahwa es krim memiliki warna sangat merah, berasa kulit buah naga, beraroma kulit buah naga dan bertekstur agak lembut, serta panelis menyatakan suka untuk penilaian keseluruhan es krim.
Monitoring of the content of heavy metals in sunflower seeds and its processing products in Ukraine for 2018–2021
Authors: Shuliak S. V. , Chechet O. M. , Haidei O. S. , Dobrozhan Yu. V. , Kobysh A. I. , Bardyk I. Yu. , Krushelnytska O. V. , Gutyj B. V. 
Published: November 2022

The article presents the results of research conducted at the State Research Institute of Laboratory Diagnostics and Veterinary-Sanitary Examination from 2018 to 2021 regarding the content of trace elements and toxic elements in sunflower seeds and their products of domestic production. During the studied period, 62 samples of sunflower seeds, 345 samples of sunflower meal, 289 samples of sunflower cake, and 68 samples of halva were analyzed. The preparation of samples was carried out by acid decomposition in nitric acid using a laboratory microwave system with closed-type autoclaves. The content of Lead, Cadmium, and Arsenic was determined by the method of atomic absorption spectrometry with electrothermal atomization and background correction with the Zeiman effect. The content of copper and zinc was determined by atomic absorption spectrometry with flame atomization with deuterium background correction. Mercury content – by the direct method of atomic absorption spectrometry. In all studied samples, the content of copper varied between 1.21–42.9 mg/kg, the content of zinc 17.7–75.40 mg/kg, the content of lead 0.011–1.121 mg/kg, the content of arsenic 0.0035–0.004 mg/kg, Mercury 0.005–0.051 mg/kg. The results of studies of sunflower seeds and halva for cadmium content were in the range of 0.052–0.234 mg/kg and 0.080–0.271 mg/kg. According to the obtained results, it was established that cadmium content exceeded the maximum permissible level value in five sunflower seeds and in eighteen halva samples, which is 2.7 % and 20.2 % of the total amount of the studied material. During the study of the content of inorganic pollutants Lead, Arsenic, Zinc, and Copper in sunflower seeds and halva, no violations of the maximum permissible levels were found. Regarding the analysis of meal and sunflower cake for the content of Cadmium, Lead, Arsenic, Copper, and Zinc, no violations of the MDR were detected. The contamination of seeds and halva with cadmium exceeded the legally permissible levels by 1.1 to 2.1 times. These results confirm literature data on the ability of sunflowers to accumulate cadmium, particularly in seeds. The analysis of the work demonstrates the need for more thorough and systematic control of sunflower raw materials both at the growing stage and in the process of harvesting, drying, and processing at various stages of feed and final product production.
Role of sex/gender on binge drinking and negative emotional memory bias through coping motivations and depressive symptoms
Authors: Johnstone Samantha , Courtenay Kesia , Girard Todd 
Published: November 2022

<p>Summary participant-level data from Studies 2 and 3 reported in "Binge Drinking Indirectly Predicts a Negative Emotional Memory Bias through Coping Motivations and Depressive Symptoms: The Role of Sex/Gender" (Johnstone et al. 2022). The Toronto Metropolitan University REB approved the project (Studies 1-3) in accordance with the Canadian Tri-Council Policy Statement (TCPS2) on ethical conduct for research involving humans and all participants (Studies 1-3) provided informed consent. </p>
Role of sex/gender on binge drinking and negative emotional memory bias through coping motivations and depressive symptoms
Authors: Girard Todd , Johnstone Samantha , Courtenay Kesia 
Published: November 2022

<p>Summary participant-level data from Studies 2 and 3 reported in "Binge Drinking Indirectly Predicts a Negative Emotional Memory Bias through Coping Motivations and Depressive Symptoms: The Role of Sex/Gender" (Johnstone et al. 2022). The Toronto Metropolitan University REB approved the project (Studies 1-3) in accordance with the Canadian Tri-Council Policy Statement (TCPS2) on ethical conduct for research involving humans and all participants (Studies 1-3) provided informed consent. </p>
Pembentukan Kader Remaja dan Pelatihan Posyandu Remaja di Desa Sidorahayu Wagir MalangPembentukan Kader Remaja dan Pelatihan Posyandu Remaja di Desa Sidorahayu Wagir Malang
Authors: Indari Indari , Asri Yuni , Utami Viyata Chanifiah , Setyowati Indah , Nurwinda Siti 
Published: November 2022

ABSTRAK Masa remaja merupakan masa peralihan dari anak-anak ke dewasa, dimasa remaja ini masalah kesehatan sangat kompleks dan penting sekali untuk segera ditangani agar tidak menimbulkan permasalahan dan tidak mengalami resiko gangguan psikologis. Dalam meningkatkan kesejahteraan kesehatan pada remaja maka solusi yang bisa ditawarkan kepada masyarakat adalah pembentukan kader remaja. Tujuan dalam kegiatan pengabdian masyarakat ini adalah membentuk kader remaja dan memberikan pelatihan posyandu remaja di desa Sidorahayu Wagir Malang. Metode yang dilakukan adalah pembentukan kader remaja dan pelatihan yang dilakukan di Balai Desa Sidorahayu Wagir Malang pada tanggal 11-19 Juli 2022 yang dihadiri oleh 7 remaja dan didampingi oleh orang tua, kader balita dan lansia. Hasil dari kegiatan ini adalah telah terbentuk kader remaja Desa Sidorahayu dengan waktu pelaksanaan setiap 1 bulan sekali bertempat di Balaidesa Sidorahayu Wagir. Kesimpulan dari kegiatan ini yaitu remaja yang hadir sangat aktif dalam mengikuti kegiatan pelatihan posyandu remaja dan dan berkomitmen dalam mendukung program salah satunya adalah kegiatan posyandu remaja yang akan dilakukan dalam setiap bulan. Kata Kunci : Pembentukan, Pelatihan, Kader, Posyandu, Remaja ABSTRACT Aadolescence is a time to transition from children to adults, in health problems are complicated in this period and it is very important to be handled immediately without risk of psychological disorders. To improve the health welfare of adolescents, the solution that can be offered to the community is to form the adolescent cadres. The purpose of this activity is to form the adolescent cadres and to provide training for adolescent posyandu in Sidorahayu village, Wagir, Malang. The method of this activity is the formation of the adolescent cadres and training at the Sidorahayu Village, Wagir, Malang on 11-19 July 2022, which was attended by 7 adolescent and their parents, some cadres. The result of this activity is that the adolescent cadres of Sidorahayu Village has been formed with the implementation time in every month at the Sidorahayu Village Wagir Malang. The conclusion of this activity is that the adolescents who attended were very active to participate in the adolescent posyandu training activities and were committed to supporting the program, one of which was the adolescent posyandu activity which would be carried out every month. Keywords : The Formation, Training, Cadre, Posyandu, Adolescent
Pelatihan Pembuatan Pupuk Cair Berbahan Dasar Limbah Cair Tahu Untuk Menunjang Pertanian
Authors: Martha Rahma Diyan , Fatimah Fatimah , Kumalasari Nurul Chamidah , Vikelavianis Elen , Adisyaningrum Ega Nurgia , Rhosida Ita , Restu Azriel , Prakoso Jalu 
Published: November 2022

ABSTRAK Desa Bendiljati Wetan merupakan Desa Binaan STIKes Karya Putra Bangsa Tulungagung yang didominasi oleh beberapa kegiatan salah satunya adalah home industri tahu. Home industri tahu berproduksi setiap hari, tidak hanya menghasilkan suatu produk siap jual, namun juga menghasilkan suatu limbah cair yang menimbulkan permasalahan tersendiri bagi masyarakat. Limbah yang dibuang menghasilkan bau yang tidak sedap sehingga mengganggu warga sekitar. Inovasi Mikroorganisme Lokal (MOL) limbah cair tahu merupakan solusi permasalahan tersebut. Tujuan dari kegiatan pengabdian ini adalah memberikan sosialisasi dan edukasi tentang bahaya limbah cair tahu dan pemanfaatannya sebagai bahan dasar MOL. Metode dalam kegiatan pengabdian ini dengan ceramah dan evaluasinya dengan pembagian angket sebelum dan sesudah kegiatan. Hasil evaluasi menunjukkan peningkatan, dari segi infomasi dan pengetahuan tentang bahaya limbah cair tahu dan pemanfaatannya sebagai bahan dasar MOL. Kegiatan pengabdian ini terlaksana dengan baik dan lancar. Kata Kunci: limbah cair tahu, home industri, MOL (Mikroorganisme Lokal) ABSTRACT Bendiljati Wetan Village is a Foster Village of STIKes Karya Putra Bangsa Tulungagung, which is dominated by several activities, one of which is the tofu home industry. The home industry knows to produce every day, producing a product ready to sell and producing liquid waste that causes problems for the community. The discarded waste produces an unpleasant odor that disturbs the surrounding residents. Innovation of Local Microorganisms (MOL) of liquid tofu waste is the solution to this problem. This service activity aims to provide socialization and education about the dangers of tofu liquid waste and its use as a basic material for MOL. The method in this service activity is lectures and evaluations with the distribution of questionnaires before and after the activity. The evaluation results showed a piece of increasing information and knowledge about the dangers of tofu liquid waste and its use as a basic material for MOL. This service activity was carried out well and smoothly. Keywords: Liquid Tofu Waste, Home Industry, LM (Local Microorganisms)
Peningkatan Pengetahuan Ibu tentang Menopause di Desa Ngemplak Mojosongo Surakarta
Authors: Trisnowati Tatik 
Published: November 2022

ABSTRAK Menopause merupakan keadaan dimana seorang perempuan tidak lagi mengalami menstruasi yang terjadi pada rentang usia 50 sampai 59 tahun. Pada lansia seiring dengan pertambahan usia, tubuh akan mengalami berbagai penurunan akibat proses penuaan. Pada masa ini sangat kompleks bagi perempuan karena akan mengalami perubahan kesehatan fisik yang akan mempengaruhi kesehatan psikologisnya. Hasil wawancara yang kami lakukan pada Senin, 13 Juni 2022 dengan ibu kader kesehatan di Desa Ngemplak RT 02 RW 29 Mojosongo, Jebres, Surakarta didapatkan hasil masih banyak ibu-ibu yang belum mengetahui mengenai menopause. Tujuan dari kegiatan ini adalah meningkatkan pengetahuan Ibu tentang menopause. Metode pelaksanaan yang digunakan berupa ceramah dan demonstrasi. Kegiatan di Desa Ngemplak RT 02 RW 29 Mojosongo, Jebres, Surakarta sangat bermanfaat bagi ibu dan keluarganya. Terdapat adanya peningkatan pengetahuan dan pemahaman ibu tentang menopause dimana sebesar 70% lansia mempunyai pengetahuan dan pemahaman baik. Terjadi peningkatan nilai rata-rata pengetahuan ibu tentang menopause sebesar 26,66. Kata Kunci: Pengetahuan, Menopause ABSTRACT Menopause is a condition in which a woman no longer experiences menstruation, which occurs between the ages of 50 and 59 years. In the elderly along with age, the body will experience various declines due to the aging process. At this time it is very complex for women because they will experience changes in physical health that will affect their psychological health. The results of the interviews we conducted on Monday, June 13, 2022 with health cadres in Ngemplak RT 02 RW 29 Mojosongo, Jebres, Surakarta, we found that there were still many mothers who did not know about menopause. The purpose of this activity is to increase mother's knowledge about menopause. The implementation method used is in the form of lectures and demonstrations. Activities in Ngemplak RT 02 RW 29 Mojosongo, Jebres, Surakarta are very beneficial for mothers and their families. There is an increase in knowledge and understanding of mothers about menopause where 70% of the elderly have good knowledge and understanding. There was an increase in the average value of maternal knowledge about menopause by 26.66. Keywords: Knowledge, Menopause.
Edukasi Luka dan Penanganan Mandiri di Rumah selama Masa Pandemi
Authors: Sidabutar Lisandra Maria Goretti Bernadette , Lumbantoruan Septa Meriana , Wardhana Adrian Dewata 
Published: November 2022

ABSTRAK Luka memiliki kondisi/derajat keparahan yang berbeda, mulai dari kondisi yang ringan hingga yang berat. Dengan adanya pembatasan mobilitas karena pandemi, masyarakat diharapkan dapat melakukan tata laksana penanganan pada luka ringan secara mandiri. Perawatan luka yang tepat sangat menentukan proses penyembuhan. Oleh karena itu, pengetahuan yang tepat terkait luka dan penanganannya sangat diperlukan oleh masyarakat. Setelah mengikuti kegiatan Pengabdian Kepada Masyarakat (PKM) ini, peserta diharapkan mampu membedakan berbagai jenis luka dan tingkat keparahannya, melakukan pertolongan pertama dan penanganan luka ringan secara mandiri, dan memahami penerapan hidup bersih serta pola makan sehari-hari yang bergizi seimbang untuk mengoptimalkan proses penyembuhan luka. Pengabdian masyarakat ini dilakukan dengan metode seminar penyuluhan dengan memanfaatkan media online Zoom Meeting Kegiatan PKM ini berjalan dengan lancar. Pengetahuan peserta diawal sudah baik dan dari hasil perbandingan pre-test dan post-test dapat dinyatakan bahwa PKM berhasil meningkatkan pengetahuan peserta tentang luka dan penangannya. Namun, masih diperlukan kegiatan lanjutan untuk membahas berbagai mitos tentang perawatan luka dan nutrisi selama penyembuhan luka. Pengetahuan masyarakat mengenai luka sudah baik, namun perlu adanya edukasi lanjutan mengenai mitos, perawatan luka, dan nutrisi untuk penyembuhan luka. Kata Kunci: Luka, Nutrisi, Pandemi, Perawatan Luka ABSTRACT Wounds have varying degrees of severity from mild to severe conditions. Due to the pandemic, communities are expected to handle wound care management independently. Proper wound care is critical to its healing process. Therefore, proper knowledge related to wounds and wound care is needed. After participating in this community service, participants are expected to distinguish various types of wounds and their severity. Moreover, the participants are expected to able to perform first aid and wound care independently and perform proper hygiene and sanitation together with a well-balanced daily diet to optimize the wound healing process. This community service was done in the form of a health education seminar using the online platform Zoom Meeting. The community service was successfully conducted. The pre seminar knowledge of participants was adequate and by comparing pre-test and post-test grades we can conclude that the seminar has increased the knowledge of participants in wounds and wound care. Further sessions are required to fully discuss the myths of wound care and nutrition in wound healing. The general knowledge of wounds is adequate but further education is required the subject of myths in wound care, and nutrition in wound healing. Keywords: Wound, Wound Care, Pandemic, Nutrition
Puding Bayam sebagai Makanan Pendamping Asi (MP-ASI) dalam Upaya Pencegahan Stunting
Authors: Purnama Robby Candra , Yulyani Vera , Atina Atina , Oktavio Aurelya Rizki Ananda , Anggraeni Devin 
Published: November 2022

ABSTRAK makanan yaitu sesuatu yang boleh dimakan, serta menunjukan arti semua jenis yang sering dikonsumsi oleh manusia. Makanan merupakan sumber protein yang berguna bagi manusia, yang berasal dari tumbuh-tumbuhan disebut protein nabati dan yang berasal dari hewan disebut protein hewani. Responden menegtahui dan memahami tentang Puding Bayam Sebagai Makanan Pendamping Asi (MP-ASI) Dalam Upaya Pencegahan Stunting. Dalam riset ini peneliti penggunakan metode Kualitatif Lapangan serta menggunakan data sekunder yang dapat membantu dalam mengembangkan karya ilmiah ini. Responden dapat menegtahui dan memahami tentang Puding Bayam Sebagai Makanan Pendamping Asi (MP-ASI) Dalam Upaya Pencegahan Stunting. Responden dapat mengetahui dan memahami tentang Puding Bayam Sebagai Makanan Pendamping Asi (MP-ASI) Dalam Upaya Pencegahan Stunting. Kata Kunci: Puding Bayam, Pendamping Asi, Pencegahan Stunting ABSTRACT Food is something that can be eaten, and shows the meaning of all types that are often consumed by humans. Food is a source of protein that is useful for humans, which comes from plants called vegetable protein and which comes from animals is called animal protein. Respondents know and understand about Spinach Pudding as Complementary Food for Breastfeeding (MP-ASI) in Stunting Prevention Efforts. In this research, the researcher uses the Field Qualitative method and uses secondary data that can assist in developing this scientific work. Respondents can know and understand about Spinach Pudding as Complementary Food for Breastfeeding (MP-ASI) in Stunting Prevention Efforts.Respondents can know and understand about Spinach Pudding as Complementary Food for Breastfeeding (MP-ASI) in Stunting Prevention Efforts. Keywords: Spinach Pudding, Breastfeeding Companion, Stunting Prevention
Analisis Asuhan Keperawatan Luka Kaki Diabetik Pada Ny. N Dan Tn. A Dengan Penggunaan Polyurethane Foam Sebagai Balutan Sekunder Di Wocare Center Bogor
Authors: Nuraeni Oktania , Hidayat Rizki , Naziyah Naziyah 
Published: November 2022

ABSTRAK Diabetes Melitus (DM) menurut American Diabetes Association, (2005) adalah sekelompok penyakit metabolik yang disebabkan oleh kelainan sekresi insulin, kerja insulin, atau keduanya. Salah satu komplikasi pada penderita DM adalah luka kaki diabetik. Luka kaki diabetik harus ditangani dengan baik dan benar, metode perawatan luka yang berkembang saat ini adalah menggunakan prinsip moisture balance atau yang dikenal sebagai metode modern dressin. Salah satu balutan yang sering digunakan adalah polyurethane foam sebagai balutan sekunder. Tujuan penelitian untuk menganalisa hasil dari perawatan luka modern dengan penggunaan polyurethane foam sebagai balutan sekunder. Metode penelitian menggunakan case study, sampel yang digunakan adalah 2 klien dengan menggunakan Instrumen pengkajian luka yang digunakan WINNERS Scale. Hasil dari penelitian ini adalah perawatan luka modern dengan polyurethane foam efektif digunakan pada luka kaki diabetik dengan eksudat sedang sampai banyak. Kesimpulannya adalah perawatan luka harus diimbangi dengan kadar gula darah yang terkontrol dan nutrisi yang baik sehingga diharapkan kepada petugas pelayanan kesehatan agar lebih memperhatikan lagi hal tersebut. Kata Kunci: Diabetes Mellitus, Luka Kaki Diabetik, Modern Dressing, Polyurethane Foam ABSTRACTAccording to the American Diabetes Association (ADA), diabetes mellitus is a collection of metabolic diseases caused by abnormalities in insulin secretion, insulin action, or both. One of the complications in people with diabetes mellitus is diabetic foot ulcers. Diabetic foot wounds must be treated properly, the current method of wound care is using the principle of moisture balance or what is known as the modern method of dressing. One of the frequently used dressings is polyurethane foam as a secondary dressing. The aim of the study was to analyze the results of modern wound care using polyurethane foam as a secondary dressing. The research method uses a case study, the sample used is 2 clients using the wound assessment instrument used by the WINNERS Scale. The result of this study is that modern wound care with polyurethane foam is effective for diabetic foot wounds with moderate to large exudate. Conclusion: Wound care must be balanced with controlled blood sugar levels and good nutrition, so it is hoped that health care workers will pay more attention to this. Keywords: Diabetic Mellitus, Diabetic Foot Ulcer, Modern Dressing, Polyurethane