bluuebunny/crossref_metadata_2025_split huggingface dataset:
EXERCISING IMPARTIALITY TO FAVOR ARISTOTLE: AVICENNA AND “THE ACCOMPLISHED ANATOMISTS” (AṢḤĀB AL-TAŠRĪḤ AL-MUḤAṢṢILŪNA)
Authors: Alpina Tommaso 
Published: August 2022

AbstractThis article analyses Avicenna's Ḥayawān III, 1, which deals with the well-known disagreement between physicians and philosophers on the origination of blood vessels (arteries and veins) and nerves. However, the proposed analysis is not limited to this chapter and its main topic. The more general purpose of this article is to reconstruct the psycho-medical context in which Avicenna's exposition lies, that is, the soul's oneness and the consequent conditions for body ensoulment (i. e. the soul's need for a primary, unitary attachment to the body through the heart and the cardiac pneuma). The article then outlines the strategy through which Avicenna presents medical positions (heart, brain, and liver are all on an equal footing) that challenge his (and Aristotle's) anatomical model, which is coherent with his theory of the soul. In this connection, firstly, the article shows how Avicenna takes physicians’ arguments apart in a philosophical context (he usually points at their logical shortcomings). Then, it clarifies the contribution of anatomy to determine the conditions of body ensoulment and, ultimately, how to reconcile medical practice with philosophical truths, if need be.
From Necessity to Flexibility: A Reflection on the Negotiations for a TRIPS Waiver for Covid-19 Vaccines and Treatments
Authors: Mercurio Bryan , Upreti Pratyush Nath 
Published: August 2022

AbstractThis article critically examines the proposed waiver of intellectual property (IP) rights for COVID-19 vaccines under the World Trade Organization Agreement's Trade-Related Aspects of Intellectual Property Rights (TRIPS), which was initiated in October 2020 when the pandemic raged and vaccines were unavailable. However, the landscape has now changed and the waiver may no longer be necessary. The Outcome Document, introduced in the TRIPS Council in May 2022, along with Ministerial Decision of June 2022 recognizes this by focusing on easing the requirements to use TRIPS-flexibilities to accomplish wider and cheaper access. In so doing, the Ministerial Decision reinforces the notion that TRIPS flexibilities can be a useful part of the policy toolkit, even in times of crisis. After providing an overview of the context and outlining justifications for the waiver proposal, the article analyses and identifies key implications and possible effects of the Ministerial Decision. The article concludes that while the Document may not be a perfect solution to the issue of access to vaccines, flexible application of TRIPS-flexibilities is a better resolution in the current environment, especially given the need for further innovation to combat COVID-19 and future pandemics.
Drivers of Future Physical Water Scarcity and Its Economic Impacts in Latin America and the Caribbean
Authors: Birnbaum Abigail , Lamontagne Jonathan , Wild Thomas , Dolan Flannery , Yarlagadda Brinda 
Published: August 2022

AbstractFuture water scarcity is a global concern with impacts across the energy, water, and land (EWL) sectors. Countries in Latin America and the Caribbean (LAC) are significant producers of agricultural goods, so disruptions resulting from water scarcity in LAC have global importance. Understanding where water scarcity in LAC could occur and what could exacerbate it is critical for strategic resource management and planning, both regionally and globally. Assessing future water scarcity in LAC is challenging given the complex interactions among the EWL sectors and the multiple uncertainties acting across spatial scales. To illuminate these dynamics, we use scenario discovery on a large ensemble representing diverse futures simulated using an integrated human‐environmental systems model. We quantify future water scarcity and its economic impacts across several physical and economic metrics. We find that future levels of reservoir storage expansion could be a significant driver of physical and economic water scarcity, highlighting the importance of strategic water infrastructure development in maintaining future water availability. Changes in crop profit are driven by both water supply and demand, emphasizing the complexity of EWL multisector dynamics. While most of LAC is poised to have abundant land and water resources available for future development, basins in Mexico and along the Pacific coast of South America experience high exposure to severe outcomes and uncertainty across outcomes for at least one metric. We find that drivers of severe scarcity vary spatially and across metrics, highlighting the region's heterogeneity and the importance of considering multiple metrics to assess water scarcity.
A Statistical Study of Modulation of Electromagnetic Ion Cyclotron Waves Observed on Ground
Authors: Upadhyay Aditi , Kakad Bharati , Kakad Amar , Rawat Rahul 
Published: August 2022

AbstractThe modulation of electromagnetic ion cyclotron (EMIC) waves by different geomagnetic pulsations is known to us from both ground and satellite observations. However, their dependence on the EMIC wave characteristics is not well explored. We report a statistical analysis of modulation of EMIC waves by short and long periodicities at the Indian Antarctic station, Maitri (L ≈ 5). We have analyzed the induction coil magnetometer data for the period of 2011–2017 and identified 6,845 EMIC wave events, out of which 5,502 events (80%) clearly showed the presence of short period modulation. These short period modulations are associated with repetitive rising tone EMIC wave emissions. Among these 5,502 EMIC wave events only 2,413 events showed presence of long period modulation, in addition to the short period modulation. Next we have examined the characteristics like start time, end time, peak frequency, frequency extent, maximum power, and dominant short and long periodicities present in each EMIC wave event. Based on the statistical analysis, we found that the dominant short and long periodicities in the EMIC waves are in the range of 1.5–3 min and 10–60 min, respectively. These short period decreases with an increase in the peak frequency of the EMIC wave. It is attributed to the decrease in magnetic field line oscillation period at lower L‐shells. Additionally, we noticed that the stronger EMIC wave events are likely to have a higher peak frequency. All these observed tendencies are examined in light of nonlinear theory, and they are found to be in good agreement.
Dynamic Evolution of Back‐Arc Basins Affected by Double Subduction
Authors: Shen Yongqiang , Liao Jie , Zhang Kuidi 
Published: August 2022

AbstractBack‐arc basins are essential geological units, formation and development of which are controlled by subduction dynamics. In the previous modeling studies, evolution of back‐arc basins was widely investigated under single subduction scenarios, suggesting that development of a back‐arc basin is only influenced by the adjacent single subduction zone. However, natural observations show that in the case of face‐to‐face double subduction, such as the New Hebrides and Tonga subduction systems in the Southwest (SW) Pacific region, evolution of back‐arc basins is likely affected by double subduction. How double subduction affects back‐arc basin evolution remains enigmatic. Here, we use 2D thermomechanical numerical modeling to investigate the dynamic evolution of back‐arc basins affected by double subduction. Our results suggest that episodic back‐arc spreading could be induced by double subduction, i.e., back‐arc spreading is first retarded by the development of a second subduction and then promoted by its slab break‐off. The double subduction further enhances upwelling of the deep mantle, facilitating the material circulation between the shallow and deep mantle. The major parameters influencing double subduction and back‐arc spreading are the distance between the two subduction zones and slab ages. Our results provide a new perspective for interpreting the episodic back‐arc spreading and the enriched back‐arc basalts in the SW Pacific region, and suggest the importance of double subduction in the geodynamic evolution of this region.
The Role of Background Stress State in Fluid‐Induced Aseismic Slip and Dynamic Rupture on a 3‐m Laboratory Fault
Authors: Cebry S. B. L. , Ke C.‐Y. , McLaskey G. C. 
Published: August 2022

AbstractFluid injection stimulates seismicity far from active tectonic regions. However, the details of how fluids modify on‐fault stresses and initiate seismic events remain poorly understood. We conducted laboratory experiments using a biaxial loading apparatus with a 3 m saw‐cut granite fault and compared events induced at different levels of background shear stress. Water was injected at 10 mL/min and normal stress was constant at 4 MPa. In all experiments, aseismic slip initiated on the fault near the location of fluid injection and dynamic rupture eventually initiated from within the aseismic slipping patch. When the fault was near critically stressed, seismic slip initiated only seconds after MPa‐level injection pressures were reached and the dynamic rupture propagated beyond the fluid pressure perturbed region. At lower stress levels, dynamic rupture initiated hundreds of seconds later and was limited to regions where aseismic slip had significantly redistributed stress from within the pressurized region to neighboring locked patches. We found that the initiation of slow slip was broadly consistent with a Coulomb failure stress, but that initiation of dynamic rupture required additional criteria to be met. Even high background stress levels required aseismic slip to modify on‐fault stress to meet initiation criteria. We also observed slow slip events prior to dynamic rupture. Overall, our experiments suggest that initial fault stress, relative to fault strength, is a critical factor in determining whether a fluid‐induced rupture will “runaway” or whether a fluid‐induced rupture will remain localized to the fluid pressurized region.
Quantifying the Global Power Needed for Sap Ascent in Plants
Authors: Quetin Gregory R. , Anderegg Leander D. L. , Konings Alexandra G. , Trugman Anna T. 
Published: August 2022

AbstractTerrestrial photosynthesis requires the evaporation of water (transpiration) in exchange for CO2 needed to form sugars. The water for transpiration is drawn up through plant roots, stem, and branches via a water potential gradient. However, this flow of water—or sap ascent—requires energy to lift the water to the canopy and to overcome the resistance of the plant’s water transporting xylem. Here, we use a combination of field measurements of plant physiology (hydraulic conductivity) and state‐of‐the‐science global estimates of transpiration to calculate how much energy is passively harvested by plants to power the sap ascent pump across the world’s terrestrial vegetation. Globally, we find that 0.06 W/m2 is consumed in sap ascent over forest dominated ecosystems or 9.4 PWh/yr (equal to global hydropower energy production). Though small in comparison to other components of the Earth’s surface energy budget, sap ascent work in forests represents 14.2% of the energy compared to the energy consumed to create sugars through photosynthesis, with values up to 18% in temperate rainforests. The power needed for sap ascent generally increases with photosynthesis, but is moderated by both climate and plant physiology, as the most work is consumed in regions with large transpiration fluxes (such as the moist tropics) and in areas where vegetation has low conductivity (such as temperate rainforests dominated by conifer trees). Here, we present a bottom‐up analysis of sap ascent work that demonstrates its significant role in plant function across the globe.
Potentialities of Complex Network Theory Tools for Urban Drainage Networks Analysis
Authors: Simone A. , Cesaro A. , Del Giudice G. , Di Cristo C. , Fecarotta O. 
Published: August 2022

AbstractUrban drainage networks (UDNs) represent important infrastructures to protect and maintain community health and safety. For these reasons, technicians and researcher are focusing more and more on topics related to vulnerability, resilience and monitoring for controlling illicit intrusions, contaminant and pathogenic spread. In the last years the complex network theory (CNT) is attracting attention as a new, useful and structured approach to analyze urban systems. The aim of this work is to evaluate potentialities of CNT approaches for UDNs vulnerability assessment and monitoring system planning. Limits and potentialities of applicability of CNT tools to UDNs are first provided evaluating the performances of standard centrality metrics. Then, it is proposed the use of tailored metrics embedding prior information, as intrinsic relevance of each node and pipe flow direction, which derive from the Horton's hierarchy and geometric data (pipe slope), respectively, without performing hydraulic simulations. The analysis is applied on two schematic literature networks of different complexity and to a real case‐study. The results suggest that vulnerability/resilience, monitoring design, contaminant and pathogenic spreads can be effectively analyzed using tailored metrics. Therefore, the proposed approach represents a complementary tool respect the more complex and computationally expensive methodologies and it is particular useful for large complex networks.
Opioid antagonism in humans: a primer on optimal dose and timing for central mu-opioid receptor blockade
Authors: Trøstheim Martin , Eikemo Marie , Haaker Jan , Frost J. James , Leknes Siri 
Published: August 2022

AbstractNon-human animal studies outline precise mechanisms of central mu-opioid regulation of pain, stress, affiliation and reward processing. In humans, pharmacological blockade with non-selective opioid antagonists such as naloxone and naltrexone is typically used to assess involvement of the mu-opioid system in such processing. However, robust estimates of the opioid receptor blockade achieved by opioid antagonists are missing. Dose and timing schedules are highly variable and often based on single studies. Here, we provide a detailed analysis of central opioid receptor blockade after opioid antagonism based on existing positron emission tomography data. We also create models for estimating opioid receptor blockade with intravenous naloxone and oral naltrexone. We find that common doses of intravenous naloxone (0.10–0.15 mg/kg) and oral naltrexone (50 mg) are more than sufficient to produce full blockade of central MOR (>90% receptor occupancy) for the duration of a typical experimental session (~60 min), presumably due to initial super saturation of receptors. Simulations indicate that these doses also produce high KOR blockade (78–100%) and some DOR blockade (10% with naltrexone and 48–74% with naloxone). Lower doses (e.g., 0.01 mg/kg intravenous naloxone) are estimated to produce less DOR and KOR blockade while still achieving a high level of MOR blockade for ~30 min. The models and simulations form the basis of two novel web applications for detailed planning and evaluation of experiments with opioid antagonists. These tools and recommendations enable selection of appropriate antagonists, doses and assessment time points, and determination of the achieved receptor blockade in previous studies.
Integrity of cerebellar tracts associated with the risk of bipolar disorder
Authors: Hou Le , Lam Bess Yin-Hung , Wong Nichol M. L. , Lu Weicong , Zhang Ruoxi , Ning Yuping , Lin Kangguang 
Published: August 2022

AbstractThis study examined the structural brain differences across individuals of different BD stages and the risks of developing bipolar disorder (BD) associated with these brain differences. A total of 221 participants who were recruited from the Guangzhou Brain Hospital and the community were categorized into four groups: NC (healthy control) (N = 77), high risk (HR) (N = 42), ultra-high risk (UHR) (N = 38), and bipolar disorder (BD) (N = 64) based on a list of criteria. Their demographics, clinical characteristics, and diffusion magnetic resonance imaging (dMRI) data were collected. ANCOVA results showed that the HR group had significantly reduced mean diffusivity (MD) (p = 0.043) and radial diffusivity (RD) (p = 0.039) of the left portico-ponto-cerebellar tracts when compared with the BD group. Moreover, logistic regression results showed that the specific diffusivity measures of cerebellar tracts (e.g., cortico-ponto-cerebellar tract), particularly the RD and MD revealed differences between groups at different BD stages after controlling for the covariates. The findings suggested that specific diffusivity (RD and MD) of cerebellar tracts (e.g., cortico-ponto-cerebellar tract) revealed differences between groups at different BD stages which is helpful in detecting the trajectory changes in BD syndromes in the early stages of BD, particularly when the BD syndromes start from HR stage.
A lymphatic-absorbed multi-targeted kinase inhibitor for myelofibrosis therapy
Authors: Ross Brian D. , Jang Youngsoon , Welton Amanda , Bonham Christopher A. , Palagama Dilrukshika S. W. , Heist Kevin , Boppisetti Jagadish , Imaduwage Kasun P. , Robison Tanner , King Leah R. , Zhang Edward Z. , Amirfazli Cyrus , Luker Kathryn E. , Lee Winston Y. , Luker Gary D. , Chenevert Thomas L. , Van Dort Marcian E. 
Published: August 2022

AbstractActivation of compensatory signaling nodes in cancer often requires combination therapies that are frequently plagued by dose-limiting toxicities. Intestinal lymphatic drug absorption is seldom explored, although reduced toxicity and sustained drug levels would be anticipated to improve systemic bioavailability. A potent orally bioavailable multi-functional kinase inhibitor (LP-182) is described with intrinsic lymphatic partitioning for the combined targeting of phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling pathways without observable toxicity. We demonstrate selectivity and therapeutic efficacy through reduction of downstream kinase activation, amelioration of disease phenotypes, and improved survival in animal models of myelofibrosis. Our further characterization of synthetic and physiochemical properties for small molecule lymphatic uptake will support continued advancements in lymphatropic therapy for altering disease trajectories of a myriad of human disease indications.
Ultrafast laser-driven topological spin textures on a 2D magnet
Authors: Strungaru Mara , Augustin Mathias , Santos Elton J. G. 
Published: August 2022

AbstractUltrafast laser excitations provide an efficient and low-power consumption alternative since different magnetic properties and topological spin states can be triggered and manipulated at the femtosecond (fs) regime. However, it is largely unknown whether laser excitations already used in data information platforms can manipulate the magnetic properties of recently discovered two-dimensional (2D) van der Waals (vdW) materials. Here we show that ultrashort laser pulses (30−85 fs) can not only manipulate magnetic domains of 2D-XY CrCl3 ferromagnets, but also induce the formation and control of topological nontrivial meron and antimeron spin textures. We observed that these spin quasiparticles are created within ~100 ps after the excitation displaying rich dynamics through motion, collision and annihilation with emission of spin waves throughout the surface. Our findings highlight substantial opportunities of using photonic driving forces for the exploration of spin textures on 2D magnetic materials towards magneto-optical topological applications.
Brief memory reactivations induce learning in the numeric domain
Authors: Schrift Gilad , Dotan Dror , Censor Nitzan 
Published: August 2022

AbstractLearning of arithmetic facts such as the multiplication table requires time-consuming, repeated practice. In light of evidence indicating that reactivation of encoded memories can modulate learning and memory processes at the synaptic, system and behavioral levels, we asked whether brief memory reactivations can induce human learning in the numeric domain. Adult participants performed a number-fact retrieval task in which they learned arbitrary numeric facts. Following encoding and a baseline test, 3 passive, brief reactivation sessions of only 40 s each were conducted on separate days. Learning was evaluated in a retest session. Results showed reactivations induced learning, with improved performance at retest relative to baseline test. Furthermore, performance was superior compared to a control group performing test-retest sessions without reactivations, who showed significant memory deterioration. A standard practice group completed active-retrieval sessions on 3 separate days, and showed significant learning gains. Interestingly, while these gains were higher than those of the reactivations group, subjects showing reactivation-induced learning were characterized by superior efficiency relative to standard practice subjects, with higher rate of improvement per practice time. A follow-up long-term retention experiment showed that 30 days following initial practice, weekly brief reactivations reduced forgetting, with participants performing superior to controls undergoing the same initial practice without reactivations. Overall, the results demonstrate that brief passive reactivations induce efficient learning and reduce forgetting within a numerical context. Time-efficient practice in the numeric domain carries implications for enhancement of learning strategies in daily-life settings.
Post-translational control of beige fat biogenesis by PRDM16 stabilization
Authors: Wang Qiang , Li Huixia , Tajima Kazuki , Verkerke Anthony R. P. , Taxin Zachary H. , Hou Zhishuai , Cole Joanne B. , Li Fei , Wong Jake , Abe Ichitaro , Pradhan Rachana N. , Yamamuro Tadashi , Yoneshiro Takeshi , Hirschhorn Joel N. , Kajimura Shingo 
Published: August 2022

AbstractCompelling evidence shows that brown and beige adipose tissue are protective against metabolic diseases1,2. PR domain-containing 16 (PRDM16) is a dominant activator of the biogenesis of beige adipocytes by forming a complex with transcriptional and epigenetic factors and is therefore an attractive target for improving metabolic health3–8. However, a lack of knowledge surrounding the regulation of PRDM16 protein expression hampered us from selectively targeting this transcriptional pathway. Here we identify CUL2–APPBP2 as the ubiquitin E3 ligase that determines PRDM16 protein stability by catalysing its polyubiquitination. Inhibition of CUL2–APPBP2 sufficiently extended the half-life of PRDM16 protein and promoted beige adipocyte biogenesis. By contrast, elevated CUL2–APPBP2 expression was found in aged adipose tissues and repressed adipocyte thermogenesis by degrading PRDM16 protein. Importantly, extended PRDM16 protein stability by adipocyte-specific deletion of CUL2–APPBP2 counteracted diet-induced obesity, glucose intolerance, insulin resistance and dyslipidaemia in mice. These results offer a cell-autonomous route to selectively activate the PRDM16 pathway in adipose tissues.