bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and Predictors of Post‐Thyroidectomy Voice Dysfunction in a Nigerian Cohort
Authors: Adeyemo Adekunle , Olasehinde Olalekan , Owojuyigbe Afolabi Muyiwa , Anagbogu Ugochukwu Josiah , Ohuche Akumbu Sylvia , Ajibare Adeola , Amusa Yemisi Bola 
Published: December 2022

AbstractBackgroundAdvances in surgical techniques have significantly improved the safety of thyroidectomy. Quality of life issues, such as voice changes, however continue to be important considerations. This study evaluated the prevalence and determinants of voice changes following thyroidectomies for non‐malignant goiters in a Nigerian Hospital.MethodologyConsecutive adults who had thyroidectomy for non‐malignant goiters were evaluated. Preoperatively, each participant had laryngoscopy and voice assessment using the Voice Handicap Index‐10. At surgery, the intubation difficulty score, size of endotracheal tubes, and duration of operation were recorded. Laryngoscopy and VHI‐10 assessments were repeated 1 week, 1 month, and 3 months after surgery. Pre and postoperative assessments were compared.ResultFifty‐four patients completed the study. Subtotal thyroidectomy was the commonest operation performed in 17 patients (31.48%), with 14 (25.93%) having total thyroidectomy. Baseline median VHI‐10 score was 6.5(IQR‐10). Five patients had abnormal preoperative laryngoscopy findings (benign vocal cord lesions). Postoperatively, seven patients had endoscopic evidence of vocal cord paralysis, six were unilateral while one was bilateral. Ten patients (18.5%) had early voice changes. Median VHI‐10 score at one week was significantly higher than baseline (10 vs. 6.5, p = 0.01). At 3 months, VHI‐10 reverted back to baseline in five of the ten patients while five patients (9.3%) had persistent voice changes. Abnormal endoscopic findings predicted the occurrence of early postoperative voice changes.ConclusionThyroidectomy for non‐malignant goiters is associated with transient voice changes, many of which revert to normal over time. Abnormal endoscopic findings predict its occurrence.
Impact of deep learning image reconstructions (DLIR) on coronary artery calcium quantification
Authors: Rossi Alexia , Gennari Antonio G. , Etter Dominik , Benz Dominik C. , Sartoretti Thomas , Giannopoulos Andreas A. , Mikail Nidaa , Bengs Susan , Maurer Alexander , Gebhard Catherine , Buechel Ronny R. , Kaufmann Philipp A. , Fuchs Tobias A. , Messerli Michael 
Published: December 2022

Abstract
Background
Deep learning image reconstructions (DLIR) have been recently introduced as an alternative to filtered back projection (FBP) and iterative reconstruction (IR) algorithms for computed tomography (CT) image reconstruction. The aim of this study was to evaluate the effect of DLIR on image quality and quantification of coronary artery calcium (CAC) in comparison to FBP.

Methods
One hundred patients were consecutively enrolled. Image quality–associated variables (noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR)) as well as CAC-derived parameters (Agatston score, mass, and volume) were calculated from images reconstructed by using FBP and three different strengths of DLIR (low (DLIR_L), medium (DLIR_M), and high (DLIR_H)). Patients were stratified into 4 risk categories according to the Coronary Artery Calcium - Data and Reporting System (CAC-DRS) classification: 0 Agatston score (very low risk), 1–99 Agatston score (mildly increased risk), Agatston 100–299 (moderately increased risk), and ≥ 300 Agatston score (moderately-to-severely increased risk).

Results
In comparison to standard FBP, increasing strength of DLIR was associated with a significant and progressive decrease of image noise (p < 0.001) alongside a significant and progressive increase of both SNR and CNR (p < 0.001). The use of incremental levels of DLIR was associated with a significant decrease of Agatston CAC score and CAC volume (p < 0.001), while mass score remained unchanged when compared to FBP (p = 0.232). The underestimation of Agatston CAC led to a CAC-DRS misclassification rate of 8%.

Conclusion
DLIR systematically underestimates Agatston CAC score. Therefore, DLIR should be used cautiously for cardiovascular risk assessment.

Key Points
• In coronary artery calcium imaging, the implementation of deep learning image reconstructions improves image quality, by decreasing the level of image noise.
• Deep learning image reconstructions systematically underestimate Agatston coronary artery calcium score.
• Deep learning image reconstructions should be used cautiously in clinical routine to measure Agatston coronary artery calcium score for cardiovascular risk assessment.
Work–family conflict, financial issues and their association with self-reported health complaints among ready-made garment workers in Bangladesh: a cross-sectional study
Authors: Dreher Annegret , Yusuf Rita , Ashraf Hasan , Ahmed Syed A K Shifat , Strümpell Christian , Loerbroks Adrian 
Published: December 2022

Abstract
Objectives
This study aims to quantify the degree of work–family conflict (WFC) and financial issues among ready-made garment (RMG) workers in Bangladesh and to investigate their potential associations with self-reported health outcomes.

Methods
We conducted a cross-sectional survey among 1118 RMG workers in labor colonies in Dhaka, Bangladesh, in February and March 2021. Descriptive analyses were performed to characterize WFC (i.e., family life disturbing the job or facing problems in family due to the job) and financial issues (i.e., savings, debt, financial obligations, financial support). We ran multivariable Poisson regression models to examine possible associations between WFC and financial issues and workers’ health (self-reported general health and 10 specific health complaints).

Results
We found low levels of WFC, low levels of savings, moderate levels of debt, and high levels of financial obligations: virtually all workers agreed they had to keep their job to financially support their spouse, children or other relatives. Only about a third of workers expected they would be able to receive financial support in case of a job loss. Work–family conflict was positively associated with poor health but not consistently with specific symptoms. Financial support was negatively associated, whereas being indebted was weakly positively associated with poor health.

Conclusions
Our findings suggest low levels of WFC among RMG workers but high levels of financial obligations. Work–family conflict was positively associated with poor health, but not consistently with specific symptoms. Being indebted was weakly positively associated with poor health. Future prospective studies are needed to confirm these findings.
Play face in Japanese macaques reflects the sender’s play motivation
Authors: Iki Sakumi , Kutsukake Nobuyuki 
Published: December 2022

AbstractAnimals often initiate social interactions by exchanging signals. Especially when initiating amicable interactions, signaling one’s friendly stance toward others in advance may be important to avoid being misunderstood as having hostile intentions. We used data on dyadic play fighting in a group of Japanese macaques,Macaca fuscata, to examine the function of “play face” at the opening of a play session. We found no support for the previously proposed hypothesis that play face expression is likelier before entering risky situations (e.g., before gaining an undue advantage over the partner) to avoid being misunderstood. The results showed that play face expression was likelier in male juveniles before initiating play with other males than in females before initiating play with males or other females and that juveniles were likelier to express play face before initiating play with others closer in age. As male Japanese macaques play more frequently than females, and juveniles prefer to play with individuals closer in age, play face expression before play initiation may reflect the individual’s motivation for subsequent play interactions. This interpretation is supported by our observation that play bouts lasted longer when initiated with bidirectional play face by both participants than when initiated without play face. We also argued that since there was no tendency that play face was likelier to be expressed toward individuals with low play propensity (e.g., females) or infrequent partners to play with (e.g., individuals more distant in age), Japanese macaques may not tactically deploy this signal to recruit reluctant partners.
Contemporary narratives about asymmetries in responsibility in global agri-food value chains: the case of the Ecuadorian stakeholders in the banana value chain
Authors: Coral Claudia , Mithöfer Dagmar 
Published: December 2022

AbstractGlobal concerns over environmental and social issues in agrifood value chains have increased and are reflected in a number of voluntary sustainability standards and regulatory initiatives. However, these initiatives are often based on poor knowledge of production realities, creating a disconnect between producing and consuming countries. Through narrative analysis, this paper reveals asymmetries in the responsibilities of the various actors participating in Ecuadorian banana value chains, providing clear problem- and solution-framings. Despite the broad range of actors interviewed, our analysis reveals convergence in two main narratives that reflect asymmetries amongst local actors in terms of their ability to participate, ability to maintain participation, and adaptation strategies in view of changing external factors. One narrative relates to sustainability adaptations, the cost of which is not shared among all value chain actors. This is combined with a downward trend in the price of bananas and the lack of a differentiated price to account for losses and costs arising from increasing sustainability standards. Another narrative reflects a value chain structure that threatens small-farm survival. It highlights the urgency of protecting small-farm activity by enforcing national regulation and developing new market segments/models that understand small-scale producer reality. Study results show that the multitude of standards is not seen as beneficial and that downstream actors rather wish for common minimum standards to reduce business costs. Compatibility between standards and local realities should be a priority for global sustainability standards adoption. Building on the problems and solution-framings of local value chain links, we give voice to local actors, and link their perceptions to existing literature and discursive politics while contributing to social transparency and addressing the democratic deficit in agrifood value chains.
Semi-endogenous growth in a non-Walrasian DSEM for Brazil: estimation and simulation of changes in foreign income, human capital, R&D, and terms of trade
Authors: Ziesemer Thomas H. W. 
Published: December 2022

AbstractIn an empirical, dynamic simultaneous equation model (DSEM) for Brazil with 22 equations and variables, we show that foreign income is a driver of economic growth besides semi-endogenous technical change. With a balance-of-payments constraint and endogenous terms of trade, the major mechanism is (i) world GDP driving exports, (ii) exports paying for imported capital goods, which (iii) enter a production function increasing output and the foreign-debt/GDP ratio and (iv) increase the endogenous labour force, and (v) slightly reduce human capital growth. The savings gap drives foreign debt and interest rates up and make the model unstable. Permanent increases of human capital increase the R&D/GDP ratio, labour-augmenting productivity, and GDP. A policy to increase the R&D/GDP ratio leads to more human capital, labour productivity and GDP levels. Both knowledge policies reduce the debt/GDP ratio. A lasting shock on the terms of trade reveals that there is no Harberger–Laursen–Metzler effect. The results hold in the presence of endogenous terms of trade, foreign debt, net foreign income, and net current transfers from abroad, and non-Walrasian (dis-)equilibrium variables: inflation and changing inventories for the goods market, and unemployment in the labour market. Policy should strengthen the weak link from R&D (research and development) to technical change and make education more attractive.
Simulation of particle resuspension by wind in an urban system
Authors: Banari Amir , Hertel Daniel , Schlink Uwe , Hampel Uwe , Lecrivain Gregory 
Published: December 2022

AbstractAir pollution caused by particle resuspension is a growing public health problem in many cities. Pollen and anthropogenic pollutants, such as heavy metal particles and micro-plastics debris, settle onto urban ground surfaces. Prolonged urban heat waves are propitious for heavy and continuous deposition. Particles in the submillimeter size range eventually resuspend by urban winds within seconds, may be inhaled, cause allergic reactions and escape the city’s boundaries. Here, the resuspension and subsequent dispersion of generic particles ranging from 10 to 100 $$\upmu$$
μ
m in size are simulated. The city area “Bayerischer Bahnhof” in Leipzig, Germany, has been chosen as a practical example. To track the resuspended particles, a Lagrangian model is used. Taking advantage of graphics processing unit, turbulent flow simulations at different wind speeds are performed in almost real time. The results show that particle resuspension starts, when the inlet wind speed beyond the canopy, that is at a height of 40 m, exceeds 7 m/s. At wind speed beyond 14 m/s, resuspension occurs in almost all city parts. At moderate wind speed, high-risk areas are identified. The effect of green infrastructures on both the flow field and particle resuspension is also investigated.
Model for a Photoresponsive Nematic Elastomer Ribbon
Authors: Sonnet André M. , Virga Epifanio G. 
Published: December 2022

AbstractWe study the equilibria of a photoresponsive nematic elastomer ribbon within a continuum theory that builds upon the statistical mechanics model put forward by Corbett and Warner (Phys. Rev. E 78:061701, 2008). We prove that the spontaneous deformation induced by illumination is not monotonically dependent on the intensity $I$
I
. The ribbon’s deflection first increases with increasing $I$
I
, as expected, but then decreases and abruptly ceases altogether at a critical value $I_{\mathrm{e}}$

I
e

of $I$
I
. $I_{\mathrm{e}}$

I
e

, which is enclosed within a hysteresis loop, marks a first-order shape transition. Finally, we find that there is a critical value of the ribbon’s length, depending only on the degree of cross-linking in the material, below which no deflection can be induced in the ribbon, no matter how intense is the light shone on it.
Integrin αVβ3 Signaling in the Progression of Osteoarthritis Induced by Excessive Mechanical Stress
Authors: Song Fanglong , Mao Xiaoyu , Dai Jun , Shan Bingchen , Zhou Zhentao , Kang Yifan 
Published: December 2022

Abstract
Osteoarthritis (OA) is believed to be linked with cartilage degeneration, subchondral bone sclerosis, and synovial inflammation that lead to joint failure, and yet treatment that can effectively reverse the pathological process of the disease still not exists. Recent evidence suggests excessive mechanical stress (eMS) as an essential role in the pathogenesis of OA. Increased levels of integrin αVβ3 have been detected in osteoarthritic cartilage and were previously implicated in OA pathogenesis. However, the role of integrin αVβ3 in the process of eMS-induced OA remains unclear. Here, histologic and proteomic analyses of osteoarthritic cartilage in a rat destabilization of the medial meniscus model demonstrated elevated expression of integrin αVβ3 as well as more serious cartilage degeneration in the medial weight-bearing area. Furthermore, results of in vitro study demonstrated that eMS led to a significant increase of integrin αVβ3 expression and phosphorylation of downstream signaling molecules such as FAK and ERK, as well as upregulated expressions of inflammatory and degradative mediators. In addition, we found that inhibition of integrin αVβ3 could alleviate chondrocyte inflammation triggered by eMS both in vivo and in vitro. Our findings suggest a central role for upregulation of integrin αVβ3 signaling in OA pathogenesis and demonstrate that activation of integrin αVβ3 signaling in cartilage contributes to inflammation and joint destruction in eMS-induced OA. Taken together, our data presented here provide a possibility for targeting integrin αVβ3 signaling pathway as a disease-modifying therapy.
A Design-assisted Spectrofluorometric Method Utilizing a One-pot Fluorescent Probe for the Quantitation of some Calcium Channel Blockers
Authors: Roshdy Aya , Salam Randa Abdel , Hadad Ghada , Belal Fathallah , Elmansi Heba 
Published: December 2022

Abstract
Based on their reaction with highly fluorescent carbon quantum dots (CQDts), a precise and reliable spectrofluorometric approach was developed for the determination of three calcium channel blockers. The studied drugs are: lercanidipine, nimodipine and nifedipine. (CQDts) were produced using a one-step hydrothermal method with ascorbic acid as the carbon source. The produced CQDts were capped by alcohol to create yellow emitters displaying a high fluorescence emission at 524 nm when excited at 325 nm. The fluorescence intensity of CQDts was noticeably quenched by each of the three calcium channel blockers. The relation between their concentrations and fluorescence quenching is linear over the concentration range of 0.5–20 µg/mL for each of the three drugs. A full factorial design was used to optimize the effect of variable factors. Therefore, under optimum experimental design conditions, the detection limits for lercanidipine, nimodipine, and nifedipine were 0.11 ± 1.09, 0.10 ± 0.25 and 0.12 ± 0.71 µg/mL, respectively. The LOQ was 0.33, 0.30, and 0.37 µg/mL respectively. The quenching of fluorescent CQDts occurred through the inner filter effect (IFE) for nimodipine, while it was mixed with dynamic quenching for lercanidipine and nifedipine. The proposed method was effectively used to determine the cited drugs in their pharmaceutical products and had an acceptable level of precision. The selectivity of the CQDts system towards the studied drugs was examined indicating no interference from interfering species.
The (co-)production of arrival neighbourhoods. Processes governing housing markets in three german cities
Authors: Hanhörster Heike , Haase Annegret , Hans Nils , Rink Dieter , Schmiz Antonie , Schrader Sebastian 
Published: December 2022

AbstractIn recent years, an emerging strand of research has focused on the role arrival neighbourhoods play for newcomers finding their footing in a new urban context. However, little is known about the underlying factors and drivers influencing their function(ing). This concerns in particular the role of the local housing market and its players in shaping their emergence and development. The paper deals with the question of how arrival neighbourhoods are (co-)produced by housing market players and how the latter are embedded in local governance structures. Looking at three German arrival neighbourhoods, the article illustrates how they are co-produced by ownership structures and the allocation practices of different housing market players. However, the strengthening of an arrival neighbourhood´s function not only depends on ownership structures but also on the capacities of municipal housing providers and civil society organisations, their strategic goals and the will for (concerted) action. Our findings show that arrival neighbourhoods can take on an important citywide function, enabling newcomers to gain a foothold in the city if three criteria are met: they are accessible/affordable for low-income groups, are equipped with infrastructures for newcomers, and are permeable with regard to residents’ relocation to other neighbourhoods.
Hydrogen Sulfide Attenuates Lipopolysaccharide-Induced Inflammation via the P-glycoprotein and NF-κB Pathway in Astrocytes
Authors: Zhao Yanling , Yan Han , Liang Xue , Zhang Zhenyu , Wang Xuan , Shi Nianwei , Bian Weihong , Di Qing , Huang He 
Published: December 2022

AbstractAstrocyte activation is key in neurodegenerative diseases. Hydrogen sulfide (H2S) exhibits neuroprotective effects on astrocytes, although the underlying molecular mechanism remains unclear. Here, we explored the effects of H2S on lipopolysaccharide (LPS)-induced astrocyte activation and astrocyte-mediated neuroinflammation. After inducing primary astrocytes via LPS exposure, H2S levels were altered. The generation and secretion of inflammatory mediators by astrocytes and their interrelation with P-glycoprotein (P-gp), an important transporter belonging to the ABC transporter family, were assessed. Activated astrocytes showed upregulated glial fibrillary acidic protein (GFAP) mRNA expression, and significantly increased proinflammatory factor mRNA/protein expression and release. The secretory capacity of astrocytes was reduced, with significantly decreased proinflammatory factor levels in culture supernatant after P-gp inhibitor verapamil pretreatment. The increase in the intracellular H2S level inhibited LPS-induced GFAP expression and P65 nuclear entry in astrocytes. mRNA expression and release of proinflammatory factors were reduced significantly, with no significant changes in cytoplasmic protein expression. S-sulfhydration levels increased significantly with the increased concentration of sodium hydrosulfide or S-adenosyl-l-methionine addition, with only moderate changes in astrocyte P-gp expression. H2S regulates NF-κB activation, leads to S-sulfhydration of P-gp, and inhibits the biosynthesis and secretion of proinflammatory factors by astrocytes. The regulatory effects of H2S on astrocytes may have clinical value for exploring new therapeutic strategies against neurodegenerative diseases.
Pricing the priceless child 2.0: children as human capital investment
Authors: Bandelj Nina , Spiegel Michelle 
Published: December 2022

AbstractThis article takes Viviana Zelizer’s (1985) Pricing the Priceless Child to the new millennium. Zelizer documented the transformation between the 19th and 20th century from an “economically useful” to an “emotionally priceless” child. She observed that by the 1930s, American children were practically economically worthless but invested with significant emotional value. What has happened to this emotionally priceless child at the dawn of the new millennium? Has there been a new transformation in the social value of children, and, if so, what might have such a transformation entailed? To address these questions, we examine overtime trends that point to increasing devotion of resources and time to children’s education, a key input in the exceedingly influential human capital theory, which connects investment into children’s human capital with their future market value. Therefore, we argue that the priceless child 2.0 is a useful-to-be human capital investment child. We use four empirical examples of overtime growth in children’s human capital investment: (a) enrollments in early childhood education, (b) federal spending on early education, (c) federal spending on K-12 programs, and (d) parental spending on child care, education and extracurricular activities. In the conclusion, we discuss some potential consequences and concerns about raising children as human capital investment.