bluuebunny/crossref_metadata_2025_split huggingface dataset:
GLP-1 receptor agonist-associated tumor adverse events: A real-world study from 2004 to 2021 based on FAERS
Authors: Yang Zheng , Lv Yuhuan , Yu Meng , Mei Mei , Xiang Linyu , Zhao Subei , Li Rong 
Published: October 2022

Background: GLP-1 receptor agonists (GLP-1RA) have demonstrated cardiovascular benefits, but the relationship between GLP-1RA and tumors is controversial. Recently, clinical trials reported higher rates of malignancy with semaglutide than control group. As real-world evidence of GLP-1RA-associated tumor risk is very limited, we explored the association of GLP-1RA and all types of neoplasms by mining the FDA Adverse Event Reporting System (FAERS) database.Methods: The FAERS data from the first quarter (Q1) of 2004 to the second quarter (Q2) of 2020 in the AERSMine were extracted to conduct disproportionality analysis, which was used by the proportional reporting ratio (PRR) to assess the relationship between GLP-1RA and all types of neoplasms. Then, the details of disproportionate GLP-1RA-associated tumor cases from Q1 2004 to Q2 2021 in the FAERS Public Dashboard were collected to analyze demographic characteristics.Results: A total of 8718 GLP-1RA-associated tumors were reported. Excluding cases with pre-existing tumors, other glucose-lowering drugs, and other GLP-1RA-related adverse events, diabetes cases with GLP-1RA as the main suspected drug were selected. GLP-1RA did not cause a disproportionate increase in all tumor cases (PRR 0.83) at the SOC level, and there was also no increase in most types of tumors associated with GLP-1RA at the HLGT/HLT levels. Significant signals were detected between GLP-1RA and certain tumors, including thyroid cancers [medullary thyroid cancer (PRR 27.43) and papillary thyroid cancer (PRR 8.68)], pancreatic neoplasms malignant (PRR 9.86), and islet cell neoplasms and APUDoma NEC (PRR 2.86). The combination of GLP-1RA with dipeptidyl-peptidase IV inhibitors (DPP4i) perhaps caused the increased reporting rate in some tumors.Conclusion: Our study provided new real-world evidence for oncology safety information of GLP-1RA. Given the wide use of GLP-1RA, clinicians should be well informed about important potential adverse events. Our pharmacovigilance analysis also prompted clinicians to raise concerns about potential tumor-related adverse effects when combining GLP-1RA with DPP4i.
Improved effect of fresh ginseng paste (radix ginseng-ziziphus jujube) on hyperuricemia based on network pharmacology and molecular docking
Authors: Zhang Hao , Liu Wei , Qi Si-Min , Chi Jian-Feng , Gao Qiang , Lin Xiang-Hui , Ren Shen , Wang Zi , Lei Xiu-juan , Li Wei 
Published: October 2022

Background: Hyperuricemia (HUA) is a metabolic disease caused by reduced excretion or increased production of uric acid. This research aims to study the practical components, active targets, and potential mechanism of the “Radix ginseng (RG)-Ziziphus jujube (ZJ)” herb pair through molecular docking, network pharmacology, and animal experiments.Methods: The potential targets of “Radix ginseng (RG)-Ziziphus jujube (ZJ)” herb pair were obtained from the TCMSP database. The therapeutic targets of HUA were acquired from the GendCards, OMIM, PharmGkb, and TTD databases. Protein-protein interaction network (PPI) was constructed in the STRING 11.0 database. The David database was used for enrichment analysis. Molecular Docking was finished by the AutoDock Vina. And we employed Radix ginseng and Ziziphus jujube as raw materials, which would develop a new functional food fresh ginseng paste (FGP) after boiling. In addition, benzbromarone (Ben) (7.8 mg/kg) and allopurinol (All) (5 mg/kg) were used as positive drugs to evaluate the hyperuricemia induced by FGP (400 and 800 mg/kg) potassium oxazine (PO) (100 mg/kg) and hypoxanthine (HX) (500 mg/kg) on mice.Results: The results showed that 25 targets in the “RG-ZJ” herb pair interacted with hyperuricemia. Then protein-protein interaction (PPI) analysis showed that TNF, IL-1β, and VEGFA were core genes. KEGG enrichment analysis showed that the Toll-like receptor signaling pathway and IL-17 signaling pathway were mainly involved. Meantime, animal experiments showed that FGP could improve the HUA status of mice by reducing serum UA BUN, XO, and liver XO levels (p &lt; 0.05, p &lt; 0.01). Furthermore, we analyzed the main ingredients of FGP by HPLC. We found that the main ingredients of FGP had solid binding activity to the core target of HUA by molecular docking.Conclusion: This study explored the active ingredients and targets of the “RG-ZJ” herb pair on HUA through network pharmacology, molecular docking, and animal experiments. It revealed the improvement of FGP in mice with HUA.
Aberrant frontolimbic circuit in female depressed adolescents with and without suicidal attempts: A resting-state functional magnetic resonance imaging study
Authors: Liu Mengqi , Huang Yang , Li Xuemei , Liu Yang , Yu Renqiang , Long Yicheng , Lv Fajin , Zhou Xinyu 
Published: October 2022

BackgroundThe neurobiological basis of suicidal behaviors among female adolescents with major depressive disorder (MDD) remains largely unclear.Materials and methodsFifty-eight drug-naïve, first-episode female adolescent MDD [including 31 patients with suicidal attempt (SA group) and 27 patients without SA (non-SA group)], and 36 matched healthy controls (HCs) participated in the present study. Resting-state functional magnetic resonance imaging (MRI) was performed on each subject. The metrics of the amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were compared among the three groups. Then seed-based functional connectivity (FC) was conducted based on the ALFF/fALFF and ReHo results, which were then correlated to clinical variables.ResultsCompared with the non-SA group, the SA group exhibited increased fALFF in the bilateral insula and right precentral gyrus, and enhanced ReHo in the left superior temporal gyrus, left middle cingulate cortex, right insula, and right precentral gyrus. Relative to the HCs, the SA group demonstrated additionally reduced fALFF and ReHo in the left middle frontal gyrus. Moreover, the SA group showed increased FC between the right precentral gyrus and the left middle frontal gyrus and left insula, and between the right insula and anterior/middle cingulate cortex compared to the non-SA and HC groups. In addition, the fALFF in the left middle frontal gyrus was positively correlated with the 17-item Hamilton Depression Rating Scale scores, and the values in the fALFF/ReHo in the right insula were positively correlated with the duration of MDD within the patient group.ConclusionThese findings highlight the multiple abnormalities of the frontolimbic circuit, which may enhance our understanding of the neurobiological basis underlying female MDD with SA during adolescence.
Potential value of serum brain-derived neurotrophic factor, vascular endothelial growth factor, and S100B for identifying major depressive disorder in knee osteoarthritis patients
Authors: Zhang Peng , Xiong Yuyuan , Wang Bangjun , Zhou Yi , Wang Zijian , Shi Jiaqi , Li Chao , Lu Xinyan , Chen Gang 
Published: October 2022

BackgroundThe chronic pain and functional limitations in osteoarthritis (OA) patients can increase risk of psychiatric disorders, e.g., major depression disorder (MDD), which may further aggravate the clinical symptoms of OA. Early detection of MDD is essential in the clinical practice of OA.Materials and methodsTwo hundred and fifteen participants with knee OA were recruited, including 134 MDD patients (i.e., MDD group) and 81 ones without MDD (i.e., control group). Among them, 81 OA participants in the control group received a 3-year follow-up and were divided into trans-MDD group (who transforming into MDD; N = 39) and non-MDD group (who keeping non-MDD; N = 42) at the end of the follow-up. The 17-item Hamilton Depression Scale (HAMD-17), Self-Rating Depression Scale (SDS), and Visual Analogue Scale (VAS) were performed. Furthermore, serum levels of brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), S100B, and IGF-1 were detected.Results(1) Compared with OA participants without MDD, there were significant decrease in serum BDNF and significant increase in serum VEGF and S100B and VAS scores in OA participants with MDD. (2) A mediation of the association was found between the VAS scores and the HAMD-17 scores through the BDNF as mediator in OA participants with MDD. (3) Significantly lower baseline BDNF levels and higher baseline S100B levels were detected in OA participants who transforming to MDD after a 3-year follow-up when compared with those who keeping non-MDD. (4) In the trans-MDD group, significant associations of the change of serum BDNF levels with rate of change of HAMD-17 scores were found, and baseline serum S100B levels positively correlated with the HAMD-17 scores at the end of the follow-up. (5) In OA participants, the composite indicator of BDNF, VEGF, and S100B differentiated MDD patients from controls with the area under the curve (AUC) value of 0.806, and the combined indicator of baseline BDNF and S100B distinguished trans-MDD participants from non-MDD ones with an AUC value of 0.806.ConclusionSerum BDNF, VEGF, and S100B may be potential biomarkers to identify MDD in OA patients. Meanwhile, serum BDNF and S100B shows great potential to predict the risk of MDD for OA.
Assessment of potential for viral contamination of user and environment via aerosols generated during hand drying: A pilot study
Authors: Moura Ines B. , Bentley Karen , Wilcox Mark H. 
Published: October 2022

BackgroundHand drying is an essential step of hand hygiene, helping remove microbes remaining on hands following handwashing. However, it is unclear whether particles dispersed or aerosolized during hand drying can also have an impact on microbe dissemination and so pose an infection risk.MethodsWe used a PR772 bacteriophage to investigate whether microorganisms remaining on hands can disperse in the washroom environment and contaminate facemasks of others sharing the same space, as a surrogate for virus inhalation risk. Hand drying using either a jet air dryer or paper towels were performed, and mask contamination by splattering and droplet deposition was investigated, up to 15 min following each procedure.ResultsFacemask contamination by splattering was 10-fold higher when a jet air dryer was used, compared with hand drying by paper towels, for both the person performing the hand drying and for standby users stationed at 1 and 2 m distance. Facemask contamination by droplet/aerosols deposition was higher in the first 5 min following hand drying, for both methods; however, virus load was significantly higher when a jet air dryer was used. In the jet air dryer assays, facemask contamination increased at 15 min post-hand drying, suggesting aerosolization of small particles that remain airborne for longer.ConclusionWhen using a jet air dryer, virus contamination dispersed further and for a longer period of time (up to 15 min post hand-drying). The method chosen for hand drying can potentially impact the airborne dissemination of microbial pathogens, including respiratory virus, and so potentially increase the risk of exposure and infection for other washroom users.
Linking suicide and social determinants of health in South Korea: An investigation of structural determinants
Authors: Zhu Yongjun , Nam Seojin , Quan Lihong , Baek Jihyun , Jeon Hongjin , Tang Buzhou 
Published: October 2022

IntroductionStudies have shown that suicide is closely related to various social factors. However, due to the restriction in the data scale, our understanding of these social factors is still limited. We propose a conceptual framework for understanding social determinants of suicide at the national level and investigate the relationships between structural determinants (i.e., gender, employment statuses, and occupation) and suicide outcomes (i.e., types of suicide, places of suicide, suicide methods, and warning signs) in South Korea.MethodsWe linked a national-level suicide registry from the Korea Psychological Autopsy Center with the Social Determinants of Health framework proposed by the World Health Organization's Commission on Social Determinants of Health.ResultsFirst, male and female suicide victims have clear differences in their typical suicide methods (fire vs. drug overdose), primary warning signs (verbal vs. mood), and places of death (suburb vs. home). Second, employees accounted for the largest proportion of murder-suicides (&gt;30%). The proportion of students was much higher for joint suicides than for individual suicides and murder-suicides. Third, among individuals choosing pesticides as their suicide method, over 50% were primary workers. In terms of drug overdoses, professionals and laborers accounted for the largest percentage; the former also constituted the largest proportion in the method of jumping from heights.ConclusionA clear connection exists between the investigated structural factors and various suicide outcomes, with gender, social class, and occupation all impacting suicide.
Determinants of mental health among youths and adolescents in the digital era: Roles of cyber and traditional bullying, violence, loneliness, and environment factors
Authors: Phan Tam Chi , Chau Brandon , Do Ha Ngoc , Vu Thao Bich Thi , Vu Khanh Long , Nguyen Hiep Duy , Nguyen Dung Tuan , Do Hoang Minh , Nguyen Nga Thu Thi , La Ly Bac Thi , Dam Vu Anh Trong , Nguyen Hien Thu , Nguyen Long Hoang , Do Anh Linh , Vu Thuc Minh Thi , Vu Le Minh Ngoc , Vu Giang Thu , Le Linh Khanh , Latkin Carl A. , Ho Cyrus S. H. , Ho Roger C. M. 
Published: October 2022

IntroductionAlthough the pathogenesis of depressive disorders is not fully elucidated, untreated adolescent depression can lead to serious sequelae such as impaired academic performance and social functioning, substance use disorders, poor self-esteem, and increased risk for suicidal ideation and attempts. Literature on adolescent mental health in Vietnam is limited, despite increased international awareness of this critical issue. This study aimed to investigate the prevalence and associations of depressive symptoms in Vietnamese adolescents.MethodsA cross-sectional, self-administered survey was conducted in five provinces of Vietnam among adolescents aged 14 to 24 years. In addition to collecting participants' demographics, a structured questionnaire was developed to examine depressive symptoms, suicidal ideation, loneliness, and cyberbullying victimization. Depressive symptoms and loneliness were assessed via the PHQ-9 and UCLA Loneliness Scale, respectively. Two-tailed Chi-squared, Mann-Whitney, and Kruskal-Wallis tests were performed to examine associations between variables. Multivariate Logistic regression models were conducted to examine the associations between prior-defined variables and positive depressive symptoms.ResultsAmong 1,600 respondents, 31.8% of participants reported having mild-moderate or severe depressive symptoms. Participants within the moderate-severe depressive symptom group had significantly lower community cohesion scores than those of participants in normal and mild depressive symptom groups (p &lt; 0.05). Youths living alone were more likely to have moderate-severe depressive symptoms (OR 2.16; 95% CI: 1.09–4.25). Cyberbullying had significant associations with depressive severity (OR 1.93; 95% CI 1.38–2.70).ConclusionThe findings of this study characterize various risk and protective factors for depression in Vietnamese youths and adolescents. The results highlight the importance of raising awareness and increasing access to educational resources for depression and other mental health illnesses. With the rising prevalence of depression, parents, teachers, and community leaders play a vital role in addressing mental health problems in adolescents.
Amphetamine-type stimulants use and socio-economic factors associated with hepatitis C antibody positivity among border drug users in South of China
Authors: Li Jing , Li Minyue , Zhang Yunjia , Li Jiashuang , Zhao Yinzhou , Lu Rong , You Jing 
Published: October 2022

BackgroundAmphetamine-type stimulants (ATS) use has become popular in China. This study explored ATS use status and related risk factors of hepatitis C virus (HCV) infection among ATS users in Jinghong City, Xishuangbanna Prefecture, Yunnan Province, China.MethodsA cross-sectional study was conducted by questionnaires from January to July 2021 in border area in Yunnan. Respondent driving sampling and consecutive sampling was carried out among border drug users, and blood samples were tested for HCV antibodies. HCV infection and related risk factors among ATS users were measured. Descriptive, univariate and multivariate analysis were conducted separately by Software SPSS 26.0.ResultsThe ATS users accounted for 85.82% (345/402) among drug users, while anti-HCV antibody prevalence was 6.38% (22/345) among ATS users. The combined use of other types of drugs (OR = 7.29, 95%CI: 1.982–26.81, P = 0.003), injection drug use (OR = 6.823, 95%CI: 1.898–24.525, P = 0.003), average monthly income (OR = 4.825, 95%CI: 1.325–17.566, P = 0.017) might increase the risk of HCV infection among ATS users. ATS users with high school or above had higher HCV infection rates than those with primary school or below (OR = 5.718, 95%CI: 1.172–27.908, P = 0.031).ConclusionTaken together, among drug users using ATS in Jinghong City, Xishuangbanna Autonomous Prefecture, Yunnan Province, combined use of multiple drugs and intravenous drug use was the high risk factor for HCV infection. Therefore, corresponding education and intervention measures should be taken.
A retrospective study of the mid-term efficacy of full-endoscopic annulus fibrosus suture following lumbar discectomy
Authors: Wang Zhenfei , Huang Sen , Xu Long , Bu Jinhui , Liu Guangpu , Wang Hui , Liang Jun , Xia Mengjiao , Chen Tao , Ma Chao , Dai Kerong , Liu Guangwang 
Published: October 2022

AimsFull-endoscopic discectomy is associated with a high risk of disc reherniation due to the poor mechanical strength of the annulus fibrosus after scar healing. It is technically difficult to place a full-endoscopic annulus fibrosus suture. We designed an annulus fibrosus suture device that can be used to suture annulus defects under microendoscopy. The present study investigated the safety and feasibility of this technology.Patients and MethodsWe retrospectively analyzed the outcomes of patients who underwent surgical treatment for lumbar disc herniation (LDH) from January 2018 to October 2020. We compared 40 patients with LDH treated with full-endoscopic annulus fibrosus suture following lumbar discectomy (LD + AFS group) with 42 patients treated with lumbar discectomy alone (LD group) regarding demographic data, symptoms, and recurrence and reoperation rates. Lumbar MRI and CT were performed 3 and 12 months. A 10-point visual analog scale (VAS) and the Oswestry Disability Index (ODI) was used to evaluate pain and the lumbar spine function.ResultsThe cohort comprised 82 patients, including 40 patients in the LD + AFS group and 42 in the LD group. All operations were successfully completed without serious complications. Reherniation occurred in no patients in the LD + AFS group and three patients in the LD group. The VAS scores for lumbar and leg pain and ODI score were significantly improved postoperatively (p &lt; 0.05).ConclusionCompared with conventional lumbar discectomy, full-endoscopic annulus fibrosus suture following full-endoscopic lumbar discectomy is a safe and effective minimally invasive technique that reduces the LDH recurrence rate.
Indicadores para triagem do transtorno do espectro autista e sua aplicabilidade na consulta de puericultura: conhecimento das enfermeiras
Authors: Pitz Isabela Soter Corrêa , Gallina Fernanda , Schultz Lidiane Ferreira 
Published: October 2022

A triagem precoce do transtorno do espectro autista (TEA) é fundamental para as terapias de estimulação, tratamento e desenvolvimento da criança, sendo a consulta de puericultura uma grande oportunidade. Objetivou-se descrever o conhecimento da enfermeira da Estratégia da Saúde da Família (ESF) sobre indicadores para a triagem do TEA e sua experiência na aplicabilidade na consulta de puericultura. Pesquisa descritiva, qualitativa realizada com nove enfermeiras da ESF em um município do Norte de Santa Catarina. Utilizou-se a análise temática para categorização e análise dos dados. Os resultados foram construídos em três categorias, sendo uma delas “Conceituando o TEA, descrevendo a importância da triagem precoce e vivenciando a assistência às crianças com TEA”. Concluiu-se que as enfermeiras desconhecem os instrumentos de triagem para TEA. Quando oportunizado nesse estudo a sua aplicabilidade, as participantes descreveram como de fácil utilização e relataram também a sua relevância.
Rede Ibero-Americana de Investigação em Serviço Social
Authors: Guerra Yolanda , Martins Alcina , Alves Carrara Virginia 
Published: October 2022

O artigo apresenta e debate uma concepção de internacionalização da pesquisa, orientada pelos organismos internacionais, em contraponto com a fecunda experiência de interlocução internacional, gestada na Rede Ibero-Americana de Investigação em Serviço Social/Trabajo Social. Problematiza alguns aspectos da atual produção de conhecimento com ênfase no trinômio Investigar, Desenvolver e Inovar (I+D+I) no contexto de internacionalização da ciência a serviço do capital e os desafios ao Serviço Social na perspectiva crítica A metodologia utilizada foi a pesquisa bibliográfico-documental, recorrendo-se à produção sobre a temática. Utilizou-se como fonte dados secundários sobre o tema da internacionalização da pesquisa e dados coletados entre outubro e novembro de 2021 no levantamento preliminar sobre a Rede Ibero-Americana. Conclui-se pela necessária constituição de redes e experiências de intercâmbio internacional, que se contraponha à lógica positivista subjacente à concepção de ciência moderna, bem como à racionalidade instrumental vigente nas propostas de internacionalização e pesquisa em rede das agências de fomento nacionais e internacionais.
Depressão e intensidade de dor crônica em idosos
Authors: Da Silva Ferreira Tatagiba Bruna , Alves Ferreira Souza Layz , Cordeiro Cárcere. Adriani , De Araújo Pereira. Gilberto , Rutyelle Serra. Joyce , Varanda Pereira. Lilian 
Published: October 2022

O estudo teve como objetivo estimar a prevalência de depressão e investigar a relação entre depressão e diferentes intensidades de dor crônica em idosos. Os participantes (n=303) foram entrevistados em salas de espera de ambulatórios de especialidades em Goiânia/GO. O CES-D e o BPI foram utilizados para avaliar depressão e intensidade de dor, respectivamente. ANOVA e Dunnet auxiliaram na análise estatística. A prevalência de depressão foi de (66,0%) (CI95%:60,7-71,3); a diferença entre os escores médios de depressão e a intensidade elevada de dor foi significativa (p<0,001). A prevalência de depressão é elevada e parece influenciada pela intensidade da experiência dolorosa.