bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caracterización clínica y epidemiológica de niños epilépticos de difícil control
Authors: Pérez Rodríguez Annelis , Alonso Carballo Jimmy , Díaz Cabote Naidelys 
Published: April 2022

Introducción: La epilepsia es una alteración del sistema nervioso central por incremento y sincronización anormal de la actividad eléctrica, que se puede manifestar por episodios recurrentes, espontáneos, intensos e impredecibles. Objetivo: Caracterizar a los niños epilépticos de difícil control según aspectos clínicos, epidemiológicos y terapéuticos. Material y métodos: Se realizó un estudio descriptivo transversal con niños epilépticos de difícil control vistos en la consulta neuro-pediátrica del centro ambulatorio en el hospital pediátrico provincial de Camagüey entre septiembre de 2019 y febrero de 2020. La muestra quedó formada por 69 niños. Se evaluó el comportamiento por edad, sexo, edad de comienzo, antecedentes prenatales, perinatales y posnatales, antecedentes familiares, tipo de crisis, manifestaciones electro-encefalográficas y drogas empleadas. Resultados: Prevaleció el sexo masculino en los pacientes con epilepsia de dificil control y la etapa de lactante fue la más representada en cuanto edad de inicio. La etiología más identificada fue la perinatal, predominando la hipoxia al nacer. Las crisis generalizadas fueron mayoría en dichos pacientes. La droga más utilizada fue el valproato de sodio, encontrándose el mayor por ciento de los pacientes en el estado de vivos controlados. Conclusiones: Los varones y el grupo de 6 a 9 años fueron los más representativos con un predominio de inicio en la lactancia. De los factores causales fueron los perinatales y la asfixia perinatal los más relevantes siendo las crisis generalizadas las más identificadas. Casi la totalidad de los pacientes presentaron manifestaciones electro-encefalográficas. El medicamento más usado fue el valproato de sodio.
Combined petrosal approach for a huge retroclival meningioma preserving the cranial nerves
Authors: Shin Dong-Won , Hong Chang-Ki 
Published: April 2022

Surgery for petroclival meningioma is challenging because cranial nerve preservation during tumor removal can be very complex. For small- to medium-sized tumors, the anatomical relationship between tumor and neurovascular structures can be assessed before surgery. However, in large tumors, cranial nerves usually cannot be seen in preoperative images. The authors present a case of a 65-year-old woman who presented with gait disturbance and hearing loss and was diagnosed with huge retroclival meningioma involving the cavernous sinus, Meckel’s cave, and internal acoustic meatus. In this video, they explain the radiographical, anatomical, and surgical considerations and demonstrate the surgical technique.
The video can be found here: https://stream.cadmore.media/r10.3171/2022.1.FOCVID21221
L5–S1 nonunion occurrence even after anterior column support combined with iliac screw fixation in long fusion for adult spinal deformity: CT-based analysis at 2-year follow-up
Authors: Park Se-Jun , Lee Chong-Suh , Park Jin-Sung , Yum Tae-Hoon , Shin Tae Soo , Chang Ji-Woo , Lee Keun-Ho 
Published: April 2022

OBJECTIVE
Iliac screw fixation and anterior column support are highly recommended to prevent lumbosacral pseudarthrosis after long-level adult spinal deformity (ASD) surgery. Despite modern instrumentation techniques, a considerable number of patients still experience nonunion at the lumbosacral junction. However, most previous studies evaluating nonunion relied only on plain radiographs and only assessed when the implant failures occurred. Therefore, using CT, it is important to know the prevalence after iliac fixation and to evaluate risk factors for nonunion at L5–S1.

METHODS
Seventy-seven patients who underwent ≥ 4-level fusion to the sacrum using iliac screws for ASD and completed a 2-year postoperative CT scan were included in the present study. All L5–S1 segments were treated by interbody fusion. Lumbosacral fusion status was evaluated on 2-year postoperative CT scans using Brantigan, Steffee, and Fraser criteria. Risk factors for nonunion were analyzed using patient, surgical, and radiographic factors. The metal failure and its association with fusion status at L5–S1 were evaluated.

RESULTS
Of the 77 patients, 12 (15.6%) showed nonunion at the lumbosacral junction on the 2-year CT scans. Multivariate analysis using logistic regression revealed that only higher American Society of Anesthesiologists (ASA) grade was a risk factor for nonunion (OR 25.6, 95% CI 3.196–205.048, p = 0.002). There were no radiographic parameters associated with fusion status at L5–S1. Lumbosacral junction rod fracture occurred more frequently in patients with nonunion than in patients with fusion (33.3% vs 6.2%, p = 0.038).

CONCLUSIONS
Although iliac screw fixation and anterior column support have been performed to prevent lumbosacral nonunion during ASD surgery, 15.6% of patients still showed nonunion on 2-year postoperative CT scans. High ASA grade was a significant risk factor for nonunion. Rod fracture between L5 and S1 occurred more frequently in the nonunion group.
L’accompagnement pastoral des couples et des familles. La perspective du ministère paroissial
Authors: Amherdt François-Xavier 
Published: April 2022

À l’heure où le nombre de mariage sacramentels diminue drastiquement, il convient d’offrir à nouveaux frais la Bonne Nouvelle de l’amour pour toujours. La contribution détaille la perspective de ce ministère auprès des conjoints selon les cinq étapes de toute pastorale sacramentelle : proposer abondamment, accueillir sans réserve, favoriser une progression, célébrer dans la beauté et accompagner le suivi mystagogique.
Strategi Pemasaran Produk Sayuran Pada Kelompok Wanita Tani di Kecamatan Tanah Sareal Kota Bogor
Authors: Prayoga Renaldi , Wibaningwati Dyah Budibruri , Anggarawati Sari 
Published: April 2022

ABSTRAK Penelitian ini dilakukan pada 4 KWT, dengan jumlah responden 20 orang yang dipilih secara sengaja. Penelitian ini bertujuan untuk menganalisis faktor lingkungan internal kelompok wanita tani yang merupakan kekuatan dan kelemahan; dan faktor lingkungan eksternal kelompok wanita tani yang merupakan peluang dan ancaman; alternatif strategi pemasaran hortikultura sayuran yang tepat dan dapat diterapkan oleh KWT. Hasil kajian penerapan strategi pemasaran diketahui menggunakan IFAS dan EFAS diketahui 2 KWT (Kentagor Mandiri dan Griya Amanah) berada di kuadran I dengan alternatif strategi SO: strategi yang dirancang dengan memanfaatkan seluruh kekuatan untuk merebut peluang pasar, KWT Puspasari terletak pada kuadran II, dengan alternatif strategi ST: strategi dengan memanfaatkan kekuatan yang dimiliki KWT untuk menghadapi ancaman, KWT Srikandi terletak pada kuadran III, dengan alternatif strategi WO: strategi yang dirancang dengan memanfaatkan peluang yang ada untuk meminimalkan kelemahan perusahaan. ABSTRACT This research was conducted at 4 KWT, with the number of respondents 20 people who were chosen deliberately. The purpose of this study was to analyze the internal environmental factors of the women farmer groups which are their strengths and weaknesses; external environmental factors for women farmer groups which are opportunities and threats; alternative marketing strategy for vegetable horticulture that is appropriate and can be implemented by KWT. The results of the study on the implementation of marketing strategies are known to use IFAS and EFAS, it is known that 2 KWT (Kentagor Mandiri and Griya Amanah) are in quadrant I with an alternative SO strategy: a strategy made by utilizing all strengths and opportunities to seize the market, KWT Puspasari is located in quadrant II, with alternative ST strategy: a strategy using the strengths of KWT to overcome threats, KWT Srikandi is located in quadrant III, with an alternative WO strategy: a strategy that is implemented by taking advantage of the opportunities KWT has to minimize company weaknesses.
Almond Skin Polyphenol Extracts Stimulate the Activation of Diacylglycerol Kinase alpha via a 67 kDa Laminin Receptor
Authors: Chinthammit Boonyaporn , Okamoto Seika , Shirai Yasuhito 
Published: April 2022

Background: Almond skins are the byproduct of the almond industry that are rich in dietary fibers and polyphenols. Recently, there has been an increasing interest in utilizing the phenolic compounds from almond skins for their functional benefits. Galloylated catechins activate diacylglycerol kinase α (DGKα) which is involved in the amelioration of diabetic nephropathy. Therefore, in this study, we investigated whether almond skin polyphenol extracts can also induce the activation of DGKα. Methods: Phenolic contents in the almond skin polyphenol extracts were identified by liquid chromatography (LC)-time of flight mass spectrometry (TOFMS). Using confocal microscopy, the translocation of green fluorescent protein (GFP)-DGKα to the cell membrane was observed upon stimulation with almond skin polyphenol extracts. To check the involvement of 67 kDa laminin receptor (67LR), pre-treatment of anti-67LR antibody was used.Results: We identified that naringenin and flavanone (2,3-dihydroflavone), which are among the phenolic contents in the almond skin polyphenol extracts identified, can also induce the activation of DGKα. In addition, we also investigated whether the pathway involves the same receptor as that of epigallocatechin-3-gallate (EGCg); the 67LR. Naringenin stimulated through the 67LR, while flavanone mainly used the 67LR-independent pathways.Conclusion: These findings were additional function of almond skin polyphenol extracts and may implicate the benefits of the intake of nuts in daily diets. Polyphenols can be extracted from almond skins as an inexpensive source. The various health benefits of polyphenols can be applied to functional foods and supplements.Keywords: flavonoid, lipid kinase, imaging, catechin, vitamin E, diabetic nephropathy
LncRNA HEIH/miR-4500/IGF2BP1/c-Myc Feedback Loop Accelerates Bladder Cancer Cell Growth and Stemness
Authors: Guo Baowei , Zhao Dan , Feng Jiao , Liu Yanmei 
Published: April 2022

BACKGROUND: Bladder cancer (BCa) is one of the most prevalent malignancies and more common in men. An aberrantly expressed long noncoding RNA (lncRNA) hepatocellular carcinoma up-regulated EZH2-associated lncRNA (HEIH) has been reported to be implicated in the progression of many cancers, but its role in BCa remains little known. Our study intended to uncover whether and how HEIH regulates BCa progression. MATERIALS AND METHODS: Quantitative real-time polymerase chain reaction (RT-qPCR) was adopted to determine HEIH expression in BCa cell lines. Functional experiments were performed to examine the effects of HEIH on BCa cell proliferation, apoptosis, migration, invasion and stemness. Bioinformatics analysis and mechanism experiments were conducted to investigate the regulatory relationship between HEIH and related molecules in BCa. RESULTS: HEIH expression was observed to be significantly increased in BCa cell lines. HEIH depletion significantly hindered BCa cell proliferation, migration and invasion. Besides, HEIH up-regulated MYC proto-oncogene, and bHLH transcription factor (c-Myc) expression to promote BCa cell stemness. Moreover, HEIH served as a sponge for miR-4500 to modulate insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) expression, thereby stabilizing c-Myc mRNA level. CONCLUSION: Our study demonstrated a positive feedback loop of HEIH/miR-4500/IGF2BP1/c-Myc in BCa progression, offering a novel insight into a possible BCa therapy.
The relationship between small pelagic fish catches with sea surface temperature and chlorophyll in Makassar Strait waters
Authors: Putri Rini Sahni , Hasrianti Hasrianti , Damis Damis , Bibin Muhammad , Putri Andi Rani Sahni , Kasim Muh , Nurdin Suhartono 
Published: April 2022

Makassar Strait is a waters area with a large and relatively fertile water resource potential. The Makassar Strait area represents the confluence zone between the Pacific Ocean and Indian Ocean fish populations. The fertility of the waters makes this area one of the breeding zones for most aquatic biota. This study aims to map the catch of small pelagic fishes with water conditions in the Makassar Strait. The data used in this study was fish catches data from Makassar Strait waters from June to September 2021. Data on environmental conditions in the form of Sea Surface Temperature and chlorophyll-a concentration in the waters during the study period were obtained from the AQUA satellite with MODIS sensors, then combined with the Geographic Information System (GIS). The results of this study indicate that the sea surface temperature range in Makassar Strait waters was between 26.7°C–31.3°C and the concentration of chlorophyll-a was between 0.7 mg/m³ - 1.30 mg/m³. The highest catch points were at two points with the same catch of the purse seine, namely 4,000 kg at 118°51'E and 5°10'59"S and at 118°52'59"E and 5°3'S, while the lowest catch was 5 kg at 118°19'E and 4°57'S. It can be concluded that the presence of fish may be influenced by the water’s conditions favored by the target fish in the Makassar Strait.
Abstrak
Selat Makassar merupakan kawasan perairan yang memiliki potensi sumberdaya perairan yang cukup besar dan relatif subur. Kawasan Selat Makassar merepresentasikan zona pertemuan antara populasi ikan Samudera Pasifik dan Samudera Hindia. Kesuburan perairannya menjadikan daerah ini sebagai salah satu zona berkembang biak bagi sebagian besar biota perairan. Penelitian ini bertujuan untuk memetakan hasil tangkapan ikan pelagis kecil dengan kondisi perairan di Selat Makassar. Data yang digunakan dalam penelitian ini merupakan data tangkapan ikan dari Perairan Selat Makassar pada bulan Juni-September 2021. Data kondisi lingkungan perairan berupa Suhu Permukaan Laut dan konsentrasi klorofil-a perairan pada periode penelitian diperoleh dari satelit AQUA dengan sensor MODIS, kemudian dikombinasikan dengan Sistem Informasi Geografis. Hasil penelitian ini menunjukkan bahwa kisaran suhu permukaan laut di Perairan Selat Makassar antara 26,7°C–31,3°C dan konsentrasi klorofil-a antara 0,7 mg/m³ - 1,30 mg/m³. Titik tangkapan tertinggi terdapat pada dua titik dengan hasil tangkapan pukat cincin yang sama yaitu 4000 kg pada 118°51’BT dan 5°10’59”LS serta pada titik 118°52’59”BT dan 5°3’LS, sedangkan tangkapan terendah sebanyak 5 kg pada titik 118°19’BT dan 4°57’LS. Disimpulkan bahwa keberadaan ikan kemungkinan dipengaruhi oleh kondisi perairan yang disukai ikan target tangkapan di Selat Makassar.
Narrativa gráfica y hermenéutica. Hacia una interpretación y comprensión de las imágenes que narran
Authors: Lonna Olvera Ivonne 
Published: April 2022

Desarrollar un proceso hermenéutico para comprender las imágenes de obras de narrativas gráficas e interrelacionar los conceptos de la hermenéutica y la literatura con el diseño gráfico son los objetivos del presente artículo.

La metodología empleada tiende puentes entre los elementos básicos de la comunicación visual, el análisis literario y la hermenéutica en tanto los lectores de narrativas gráficas —cómics, novelas gráficas, libros álbum, fotolibros y animaciones—, caen en inmersión por las imágenes y se preguntan qué hay en ellas. Los hallazgos de esta investigación nutren la teoría del diseño en tanto los modelos literarios actuales son eclécticos y complejos.

Los lectores interpretan lo que leen en imágenes desde sus propios esquemas de sentido para descifrar el juego de significados que estás guardan; lo que implica más allá de percepción, un proceso de raciocinio, por lo que desdoblar disciplinas para comprender obras cuyas imágenes no ilustran textos, sino las que narran, explica la fuerza de la visualidad en la literatura contemporánea y apunta a la originalidad de este tipo de investigaciones.

Como conclusión se apunta hacia la importancia de un proceso hermenéutico para la comprensión de narrativas gráficas, terreno ganado en la literatura por los diseñadores.
Monitoring Multidrug-Resistant Acinetobacter baumannii Infections in the Neurosurgery ICU Using a Real-Time Surveillance System
Authors: Zhu Yuting , Ni Mingzhu , Fang Xiaofang , Lei Tonghua , Sun Yan , Ding Reng , Hu Xiuqiong , Bian Chengxiang 
Published: April 2022

Abstract
Multidrug-resistant Acinetobacter baumannii (MDR-AB) infections are becoming increasingly common. The Real-Time Nosocomial Infection (NI) Surveillance System (RT-NISS) was used to monitor MDR-AB NI in intensive care units (ICUs) to prevent NI outbreaks. Therefore, the RT-NISS was used in the current study to monitor MDR-AB infections in a neurosurgery ICU. Clinical interventions, including recommended antibiotics, bacterial distribution in the patient analysis, and bed adjustments, were carried out based on the monitoring results. The RT-NISS was also used to monitor clinical data, implement, and provide training on NI control. The RT-NISS detected a potential cluster of XDR-AB when five patients admitted to the neurosurgery ICU were tested positive for AB between 11 and 17 June 2019. Only two infected cases originated in the hospital, and there was no NI outbreak. The hospital Infection Control Department took appropriate measures to prevent cross-infection; specifically, an epidemiologic investigation and environmental assessment were conducted, and NI prevention and outbreak management training was provided. In summary, the RT-NISS enhanced the timeliness and efficacy of NI control and surveillance in a neurosurgery ICU.

In order to prevent NI outbreaks, the Real-Time Nosocomial Infection (NI) Surveillance System (RT-NISS) was employed to monitor MDR-AB NI in critical care units (ICU). Based on the monitoring data, clinical actions such as required antibiotics, bacterial distribution in the patient analysis, and bed changes were carried out. In a neurosurgery ICU, the RT-NISS improved the timeliness and efficacy of NI control and surveillance.
Expression Level of the mip, pmp18D, and ompA Genes in Chlamydia abortus Isolated from Aborted Ewes
Authors: Arif Eman Dhahir , Saeed Nahla Mohammad , Rachid Shwan Kamal , Dyary Hiewa Othman , Rashid Peshnyar M.A. 
Published: April 2022

Abstract
In this manuscript, we report the proteins macrophage infectivity potentiator (mip, CAB080), major outer membrane protein (momp, CAB048), and polymorphic outer membrane protein (pmp18D, CAB776) that are expressed in different times of pregnancy in mice infected with Chlamydia abortus. Enzootic abortion of ewes (EAE) by C. abortus, an obligate intracellular pathogen, is a critical zoonotic disease-causing significant economic loss to livestock farming globally. This study was carried out for the detection and characterization of macrophage infectivity potentiator (mip, CAB080), major outer membrane protein (momp, CAB048), and polymorphic outer membrane protein (pmp18D, CAB776) using RT-qPCR. These proteins are believed to be expressed as virulence factors in C. abortus isolated from aborted ewes. BALB/c mice (pregnant and nonpregnant) were used as an animal model to be injected intraperitoneally with C. abortus culture in Vero cells since the endometrial lymphoid tissues of these animals resembles that of ewes. Also, the short duration of pregnancy in mice makes them a suitable animal model for obstetric studies. Tissue samples were taken from the mice after 10, 15, and 20 days of pregnancy to compare the expression of the genes mip, pmp18D, and ompA. Transcription level was quantified using RT-qPCR, the GAPDH transcription quantification, as a normalization signal. Abortion occurred in pregnant mice, and apparent differences between the transcriptional levels of the mip, pmp18D, and ompA genes in the samples taken during different time intervals of pregnancy were not observed (p > 0.05). The result indicated that the three bacterial genes, mip, pmp18D, and ompA, play a role as virulence factors in abortion and are differentially expressed in pregnant and nonpregnant animals. Inactivation of the genes is suggested to confirm the hypothesis.
The first achievement of complete remission in childhood leukemia by treatment with the folic acid antagonist aminopterin
Authors: Izraeli Shai 
Published: April 2022

TITLE Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin).
AUTHORS Farber S, Diamond LK. Mercer RD, Slyvester RF Jr, Wolff JA.
JOURNAL New England Journal of Medicine. 1948;238(23):787-793. https://pubmed.ncbi.nlm.nih.gov/18860765/
Survival Analysis of Pediatric Wilms Tumor Based on Risk Identification
Authors: Andy Andy , Sigumonrong Yacobda 
Published: April 2022

Background: Wilms Tumor (WT) or nephroblastoma is the most common primary malignant tumor of the kidney found in children (comprising about > 95% of all kidney tumors). The study of WT prognostic factors has not been elaborated enough in Indonesia. This study aimed to determine the prognostic factors of WT patients in Adam Malik Hospital, Medan. Methods: This study was conducted with a retrospective design due to the rarity of WT cases. A total of 21 WT patients diagnosed from 2003 to 2019 were taken from medical records at Adam Malik Hospital, Medan. Univariate and multivariate Cox regression analyses were performed to determine the independent prognostic factors of WT. The primary endpoint of this study was patients’ overall survival (OS) obtained by the Kaplan-Meier analysis on significant variables. Results: From the univariate Cox regression analysis, gender was found to be the sole significant factor (HR = 0.218, p = 0.005) where males have a lower hazard ratio. The multivariate Cox regression analysis yielded an age of diagnosis (HR = 13.860, p = 0.014) and complete tumor removals (HR = 0.056, p = 0.008). The Kaplan-Meier analysis was performed on three significant variables mentioned before. Only gender yielded a significant Mantel-Cox log-rank score (p = 0.002) with male patients found to have better survivability with a median survival of 476 days compared to that of females of 11 days. The three-year survival of males was 45.45% while all females did not survive until the cut-off. Conclusions: Three prognostic factors, including children’s gender, age of diagnosis, and tumor removal status, were confirmed to be prognostic factors for the overall survival of children with WT. Further studies covering broader demographic areas were suggested to confirm significant results.
Effects of m-Health interventions on physical activity level and sedentary behavior in pre-hypertensive and hypertensive individuals: a systematic review
Authors: Martins Aline de Oliveira , Goessler Karla Fabiana , De Marchi Ana Carolina Bertoletti 
Published: April 2022

This study aims to identify the effects of m-Health interventions on physical activity (PA) level and sedentary behavior (SB) in pre-hypertensive and hypertensive adults. Therefore, a systematic literature search was conducted according to the guidelines defined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), in the scientific databases Web Of Science, MEDLINE/PubMed, SciELO, Scopus, and ACM Digital Library. Eligibility criteria were: clinical trials; description of the functionalities of m-Health apps (reminders, goals, wearables); description of the intervention characteristics (i.e., duration, expertise of professionals involved in the supervision, and others) and blood pressure assessment. In the end, 1447 studies were identified, of which 147 were duplicates. Through the screening by titles and abstracts, 43 studies were classified as relevant. However, only 12 studies met the eligibility criteria and were included in this systematic review. Most studies presented favorable results with the use of m-Health apps to increase PA and reduce SB. In addition, increasing PA and reducing SB might be an important non-pharmacological therapy to decrease blood pressure in hypertensive patients, when they follow the minimum recommendations proposed by the PA guidelines of the World Health Organization (WHO). However, further studies are still needed to assess the relationship between SB, PA and the use of m-Health interventions.