bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transitioning care in youth-onset type 1 and type 2 diabetes: a scoping review protocol using the socio-ecological model framework
Authors: Ude Assumpta O , De Baca Tomás Cabeza , Dixon Sydney A , Arboine Sue-Ann , Terry Nancy L , Chung Stephanie T 
Published: October 2022

IntroductionThe transition from paediatric to adult diabetes care in youth-onset diabetes (type 1 diabetes mellitus, Y-T1DM and type 2 diabetes mellitus, Y-T2DM) is associated with worsening glycaemic control, missed clinical visits, decreased medication adherence and the emergence of cardiometabolic complications. The socio-ecological challenges that influence transitioning to adult diabetes care may be distinct between Y-T1DM and Y-T2DM. The goal of this scoping review is to map the state of the literature on transitioning care in Y-T2DM compared with Y-T1DM and to identify the main sources and types of evidence available. The objectives are : (1) to identify the factors within the socio-ecological framework (individual, relationship, community, societal) associated with transitioning to adult care in Y-T2DM compared with Y- T1DM, and (2) to identify knowledge gaps related to transitioning to adult care.MethodsThe scoping review protocol and reporting will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for scoping reviews guidelines. A systematic search of scientific databases (PubMed, Embase, Cumulative Index to Nursing and Allied Health, Scopus and APA PsycNet will be undertaken for articles between 1 January 1990 and 30 September 2022. Study designs will include peer-reviewed experimental and quasi-experimental published studies without language or country-specific restrictions. We will exclude articles on other diabetes subtypes and will exclude non-peer reviewed articles such as opinion papers, anecdotal reports or supplementary commentaries.AnalysisReferences will be collated, sorted and extracted using Covidence. Factors associated with transition from paediatric to adult diabetes care in Y-T1DM and Y-T2DM will be identified using the socio-ecological framework and results will be presented in narrative format, tables, and summary graphs.Ethics and disseminationEthical approval will not be applicable for this review.Trial registration numberhttps://osf.io/k2pwc.
ARCHS: adult recipients of cochlear implants: health and social long-term outcomes–a state-specific and national population-based retrospective cohort study protocol
Authors: Mitchell Rebecca J , Lystad Reidar P , Boisvert Isabelle , McMaugh Anne , Cantle Moore Robyn , Walsan Ramya 
Published: October 2022

IntroductionWhile the majority of adults with severe-to-profound hearing loss and poor speech perception outcomes with hearing aids benefit from receiving a cochlear implant, the long-term health and social benefits for implant recipients are yet to be explored. The objective of the ARCHS research is to provide a better understanding of the health and social factors that play a role in the lives of adults with a cochlear implant up to 10 years after the procedure.Method and analysisThis research will involve conducting two retrospective cohort studies of adults aged ≥18 years who received a cochlear implant during 2011–2021 using linked administrative data first within New South Wales (NSW) and second Australia-wide. It will examine health service use and compare health and social outcomes for younger (18–64 years) and older (≥65 years) cochlear implant recipients.Ethics and disseminationEthical approval was received from the NSW Population Health Services Research Ethics Committee for the NSW cohort study (Reference: 2022/ETH00382/2022.07) and from the Macquarie University ethics committee for the national cohort study (Reference: 520221151437084). Research findings will be published in peer-reviewed journals and presented at scientific conferences.
Comparison of PD-L1 tumor cell expression with 22C3, 28-8, and SP142 IHC assays across multiple tumor types
Authors: Maule Jake G , Clinton Lani K , Graf Ryon P , Xiao Jinpeng , Oxnard Geoffrey R , Ross Jeffrey S , Huang Richard S P 
Published: October 2022

BackgroundMultiple PD-L1 immunohistochemistry (IHC) assays, including DAKO 22C3, DAKO 28-8, and Ventana SP142 PD-L1 IHC assays, have been approved by the Food and Drug Administration as a companion diagnostic (CDx) for various antiprogrammed death-1 and antiprogrammed death ligand 1 (PD-L1) based cancer immunotherapies. Here we present 22C3, 28-8, and SP142 analysis of 418 tumor specimens encountered in routine clinical practice.MethodsAll specimens were tested with 22C3, 28-8, and SP142 assays following the manufacturer’s established staining protocols.ResultsThe same PD-L1 status (defined as tumor cell expression (TC) scores with all three assays ≥1% or all <1%) was observed in 60.0% (251/418) tumor specimens (45.9% (192/418) were triple negative and 14.1% (59/418) were triple positive). A total of 54.1% (226/418) tumor cases were positive with at least one IHC assay (94.2% (213/226), 77.0% (174/226), and 28.8% (65/226) of these were positive for 22C3, 28-8 and SP142, respectively). Among the 40.0% (167/418) tumor cases that showed a different PD-L1 status, 62.3% (104/167) were 22C3+/28-8+/SP142−, and 28.7% (48/167) were 22C3+/28-8−/SP142−. The same PD-L1 status with all three antibody clones was observed in 48.7% (97/199) of NSCLC cases, and among these, 54.6% (53/97) were triple negative and 45.4% (44/97) triple positive. A total of 73.4% (146/199) NSCLC cases were positive with at least one IHC assay (95.2% (n=139/146), 82.2% (n=120/146), and 32.2% (n=47/146) were positive for 22C3, 28-8, and SP142, respectively). Among the 51.3% (102/199) NSCLC cases that showed a different status among the three IHC assays, 67.6% (69/102) were 22C3+/28-8+/SP142−, and 23.5% (24/102) were 22C3+/28-8−/SP142−. A total of 81.1% (43/53) lung squamous cell carcinoma, 72.1% (88/122) of lung adenocarcinoma, 69.6% (16/23) of non-small cell lung cancer (NSCLC) not otherwise specified (NOS), and 50.0% (4/8) of small cell lung carcinoma cases were positive with at least one IHC assay.ConclusionsOur data suggest that 22C3 is the most sensitive PD-L1 IHC assay for tumor cell expression, followed by 28-8 and in turn by SP-142. These findings represent an additional factor for clinical teams to consider when deciding which PD-L1 IHC assay (and in turn which CDx-associated PD-L1 based immunotherapy) is most appropriate for each individual patient.
Symptoms, performance status and phase of illness in advanced cancer: multicentre cross-sectional study of palliative care unit admissions
Authors: Ohinata Hironori , Aoyama Maho , Hiratsuka Yusuke , Mori Masanori , Kikuchi Ayako , Tsukuura Hiroaki , Matsuda Yosuke , Suzuki Kozue , Kohara Hiroyuki , Maeda Isseki , Morita Tatsuya , Miyashita Mitsunori 
Published: October 2022

ObjectivesTo clarify the relationship between Phase of Illness at the time of admission to palliative care units and symptoms of patients with advanced cancer.MethodsThis study was a secondary analysis of the East Asian collaborative cross-cultural Study to Elucidate the Dying process. Palliative physicians recorded data, including Phase of Illness, physical function and the Integrated Palliative care Outcome Scale. We used multinomial logistic regression to analyse ORs for factors associated with Phase of Illness. Twenty-three palliative care units in Japan participated from January 2017 to September 2018.ResultsIn total, 1894 patients were analysed—50.9% were male, mean age was 72.4 (SD±12.3) years, and Phase of Illness at the time of admission to the palliative care unit comprised 177 (8.9%) stable, 579 (29.2%) unstable, 921 (46.4%) deteriorating and 217 (10.9%) terminal phases. Symptoms were most distressing in the terminal phase for all items, followed by deteriorating, unstable and stable (p<0.001). The stable phase had lower association with shortness of breath (OR 0.73, 95% CI 0.57 to 0.94) and felt at peace (OR 0.73, 95% CI 0.56 to 0.90) than the unstable phase. In the deteriorating phase, weakness or lack of energy (OR 1.20, 95% CI 1.02 to 1.40) were higher, while drowsiness (OR 0.82, 95% CI 0.71 to 0.97) and felt at peace (OR 0.81, 95% CI 0.71 to 0.94) were significantly lower.ConclusionOur study is reflective of the situation in palliative care units in Japan. Future studies should consider the differences in patients’ medical conditions and routinely investigate patients’ Phase of Illness and symptoms.Trial registrarion numberUMIN000025457
A systematic review examining associations between physical activity, sedentary behaviour, and sleep duration with quality of life in older adults aged 65 years and above
Authors: Hakimi Shawn , Kaur Sahej , Ross-White Amanda , Martin Luc J. , Rosenberg Mark W. 
Published: October 2022

This systematic review examined the associations between movement behaviours (i.e., physical activity, sedentary behaviour, and sleep duration) and quality of life (QOL) in adults ≥65 years of age. Four databases were searched in June 2021. Studies were eligible for inclusion if published within the last 20 years, peer-reviewed, examined apparently healthy older adults, and analysed ≥2 movement behaviours together. QOL was represented by the World Health Organization Quality of Life measure which conceptualizes QOL by distinct domains. Study results were categorized and presented by domain. Risk of bias was completed for all included studies using methods described in the Cochrane Handbook. Thirty-one studies with 307 292 participants were included that examined QOL outcomes across seven domains: superdomain (composite measures), perceived physical health, mental and psychological states, level of independence, social relationships, environment, and general health. Findings indicated that moderate-to-vigorous intensity physical activity was favourably associated with QOL. Time re-allocation studies that showed moving time into physical activity from sedentary behaviour were associated with favourable QOL changes. The evidence regarding sedentary behaviour and sleep duration was inconsistent. The quality of evidence was very low for all domains. In conclusion, there is consistent evidence that physical activity improves QOL in adults ≥65 years of age. International Prospective Register of Ongoing Systematic Reviews (PROSPERO) registration No.: CRD42021260566.
Accelerated motion in general relativity: fate of the singularity
Authors: Bhattacharyya Indranath , Ray Saibal 
Published: October 2022

AbstractUnder general relativity, the paths of accelerated test particles are taken into account. It is examined whether such accelerations have any influence on the ‘singularity’ of the spacetime. The Raychaudhuri equation for the congruence of the time-like curves describing the paths of the accelerated particles is considered to calculate a few physical attributes. It is shown that if the acceleration of the test particles exceeds a particular value, then the congruences of the accelerated time-like curves do not encounter any singularity although the usual energy conditions are violated or modified. It is shown further that in the curved spacetime of general relativistic framework one may generate a system of transformations that is a generalization of the Rindler coordinates related to accelerated frame in the flat Minkowski spacetime. To show the influence of the acceleration of test particle on singularity of a particular spacetime the Schwarzschild spacetime is considered. Taking tidal deviation related acceleration term, it is shown that the acceleration may attain a specific value for which the modified Kretschmann scalar vanishes in a spherical neighbourhood of the singularity and thus the Schwarzschild singularity disappears. In the context of singularity as ‘geodesic incompleteness’ of the spacetime manifold it is also proved that prescribing an appropriate acceleration term on the maximal geodesic defined in a finite interval one may extend it up to infinite proper time and hence the spacetime becomes singularity free. Such results hold at the price of violating the usual energy conditions.
Chiral vortical catalysis
Authors: Jiang Yin 
Published: October 2022

AbstractGluon interaction introduces remarkable corrections to the magnetic polarization effects on the chiral fermions, which is known as the inverse magnetic catalysis. It is a natural speculation that the vorticity, which has many similar properties as magnetic field, would bring non-negligible contribution to the chiral rotational suppression. Using an intuitive semi-classical background field method we studied the rotation dependence of the effective strong interaction coupling constant. Contrary to the magnetic field case the rotation increases the effective coupling which would slow down the condensate melting with temperature. This could be named as the chiral vortical catalysis or inverse rotation suppression. Imposing such dependence on the 4-fermion coupling in the NJL model, we numerically checked this analysis qualitatively. The pseudo critical temperature is shown to rise with the rotation and approach saturation eventually which may be induced by the model cutoff.
Optical features of rotating black hole with nonlinear electrodynamics
Authors: Zubair M. , Raza Muhammad Ali , Abbas Ghulam 
Published: October 2022

AbstractIn this article, we considered the strong field approximation of nonlinear electrodynamics black hole and constructed its rotating counterpart by applying the modified Newman–Janis algorithm. The corresponding metric function in the strong field limit of the static black hole is identified in order to study the radius of photon sphere. However, the metric function for the rotating counterpart in the strong field limit is considered in order to study the horizon radius w.r.t spin parameter. We considered the Hamilton–Jacobi method to derive the geodesic equations for photon and constructed an orthonormal tetrad for deriving the equations for celestial coordinates in the observer’s sky. Shadows, distortions and energy emission rates are investigated and the results are compared for different values of nonlinear electrodynamics parameter, charge and spin. It is found that the presence of the nonlinear electrodynamics parameter affects the shape and size of the shadows and thus the distortion in the case of rotation. It is also found that the nonlinearity of electrodynamics diminishes the flatness in the shadow due to the effect of spin and other parameters.
Approximated analytical solution of the Landau–Lifshitz equation in tightly focused laser beams in the ultrarelativistic limit
Authors: Hosak Adrian , Di Piazza Antonino 
Published: October 2022

Abstract
The Landau–Lifshitz equation is widely considered as the equation, which correctly includes the effects of radiation reaction in the classical motion of an electric charge. Here, we provide an approximated analytical solution of the Landau–Lifshitz equation in the presence of a virtually arbitrary electromagnetic field by making the assumptions that the electron’s initial energy is the largest dynamical energy in the problem. We show that in a regime where radiation–reaction effects are a small correction of the Lorentz dynamics, the four-momentum of the electron can be determined perturbatively in the ultrarelativistic limit. We explicitly compute the electron four-momentum up to the first order and in the experimentally relevant case of an ultrashort, tightly focused laser beam as an external field.

Graphical abstract
An overview of underground energy-related product storage and sequestration
Authors: Schultz Richard A. , Heinemann Niklas , Horváth Birgit , Wickens John , Miocic Johannes M. , Babarinde Oladipupo Oluwatoyin , Cao Wenzhuo , Capuano Paolo , Dewers Thomas A. , Dusseault Maurice , Edlmann Katriona , Goswick Raven A. , Hassanpouryouzband Aliakbar , Husain Taha , Jin Wencheng , Meng Jingyao , Kim Seunghee , Molaei Fatemeh , Odunlami Tosin , Prasad Umesh , Lei Qinghua , Schwartz Brandon A. , Segura José M. , Soroush Hamed , Voegeli Samuel , Williams-Stroud Sherilyn , Yu Haitao , Zhao Qi 
Published: October 2022

Abstract

Storage of energy-related products in the geological subsurface provides reserve capacity, resilience, and security to the energy supply chain. Sequestration of energy-related products ensures long-term isolation from the environment and, for CO
2
, a reduction in atmospheric emissions. Both porous-rock media and engineered caverns can provide the large storage volumes needed for energy security and supply-chain resilience today and in the future. Methods for site characterization and modelling, monitoring, and inventory verification have been developed and deployed to identify and mitigate geological threats and hazards such as induced seismicity and loss of containment. Broader considerations such as life-cycle analysis, environment, social and governance (ESG) impact and effective engagement with stakeholders can reduce project uncertainty and cost while promoting sustainability during the ongoing energy transition toward net-zero or low-carbon economies.
CS-TSSOS: Correlative and Term Sparsity for Large-Scale Polynomial Optimization
Authors: Wang Jie , Magron Victor , Lasserre J. B. , Mai Ngoc Hoang Anh 
Published: October 2022

This work proposes a new moment-SOS hierarchy, called
CS-TSSOS
, for solving large-scale sparse polynomial optimization problems. Its novelty is to exploit simultaneously
correlative sparsity
and
term sparsity
by combining advantages of two existing frameworks for sparse polynomial optimization. The former is due to Waki et al. [
40
] while the latter was initially proposed by Wang et al. [
42
] and later exploited in the TSSOS hierarchy [
46
,
47
]. In doing so we obtain CS-TSSOS—a two-level hierarchy of semidefinite programming relaxations with (i) the crucial property to involve blocks of SDP matrices and (ii) the guarantee of convergence to the global optimum under certain conditions. We demonstrate its efficiency and scalability on several large-scale instances of the celebrated Max-Cut problem and the important industrial optimal power flow problem, involving up to six thousand variables and tens of thousands of constraints.
Meta-Analysis of the Test–Retest Repeatability of [18F]-Fluorodeoxyglucose Standardized Uptake Values: Implications for Assessment of Tumor Response
Authors: Shankar Lalitha K. , Huang Erich , Litiere Saskia , Hoekstra Otto S. , Schwartz Larry , Collette Sandra , Boellaard Ronald , Bogaerts Jan , Seymour Lesley , deVries Elisabeth G.E. 
Published: October 2022

Abstract

Purpose:
Currently, guidelines for PET with 18F-fluorodeoxyglucose (FDG-PET) interpretation for assessment of therapy response in oncology primarily involve visual evaluation of FDG-PET/CT scans. However, quantitative measurements of the metabolic activity in tumors may be even more useful in evaluating response to treatment. Guidelines based on such measurements, including the European Organization for Research and Treatment of Cancer Criteria and PET Response Criteria in Solid Tumors, have been proposed. However, more rigorous analysis of response criteria based on FDG-PET measurements is needed to adopt regular use in practice.

Experimental Design:
Well-defined boundaries of repeatability and reproducibility of quantitative measurements to discriminate noise from true signal changes are a needed initial step. An extension of the meta-analysis from de Langen and colleagues (2012) of the test–retest repeatability of quantitative FDG-PET measurements, including mean, maximum, and peak standardized uptake values (SUVmax, SUVmean, and SUVpeak, respectively), was performed. Data from 11 studies in the literature were used to estimate the relationship between the variance in test–retest measurements with uptake level and various study-level, patient-level, and lesion-level characteristics.

Results:
Test–retest repeatability of percentage fluctuations for all three types of SUV measurement (max, mean, and peak) improved with higher FDG uptake levels. Repeatability in all three SUV measurements varied for different lesion locations. Worse repeatability in SUVmean was also associated with higher tumor volumes.

Conclusions:
On the basis of these results, recommendations regarding SUV measurements for assessing minimal detectable changes based on repeatability and reproducibility are proposed. These should be applied to differentiate between response categories for a future set of FDG-PET–based criteria that assess clinically significant changes in tumor response.
Randomized Phase II Trial of Sunitinib or Cediranib in Alveolar Soft Part Sarcoma
Authors: Nguyen James , Takebe Naoko , Kummar Shivaani , Razak Albiruni , Chawla Sant P. , George Suzanne , Patel Shreyaskumar R. , Keohan Mary Louise , Movva Sujana , O'Sullivan Coyne Geraldine , Do Khanh , Juwara Lamin , Augustine Brooke , Steinberg Seth M. , Kuhlmann Laura , Ivy S. Percy , Doroshow James H. , Chen Alice P. 
Published: October 2022

AbstractPurpose:Alveolar soft part sarcoma (ASPS) is a rare, highly vascular tumor with few treatment options. We designed a phase II randomized trial to determine the activity and tolerability of single-agent cediranib or sunitinib in patients with advanced metastatic ASPS.Patients and Methods:Patients 16 years of age and older were randomized to receive cediranib (30 mg) or sunitinib (37.5 mg) in 28-day cycles. Patients could cross over to the other treatment arm at disease progression. The primary endpoint was to measure the objective response rate (ORR) for each agent. Median progression-free survival (mPFS) for the two arms was also determined.Results:Twenty-nine of 34 enrolled patients were evaluable for response. One patient on each of the initial two treatment arms had a partial response (ORR: 6.7% and 7.1% for cediranib and sunitinib, respectively). Twenty-four patients had a best response of stable disease (86.7% and 78.6% for cediranib and sunitinib, respectively). There were no significant differences in mPFS for the two treatment arms. Clinical benefit (i.e., objective response or stable disease for a minimum of four or six cycles of therapy) on the first-line tyrosine kinase inhibitor (TKI) therapy did not predict benefit on the second-line TKI. Both drugs were well tolerated. As of August 2021, 1 patient (unevaluable for ORR) remains on study.Conclusions:The study did not meet its endpoints for ORR. Although both TKIs provided clinical benefit, the outcomes may have been attenuated in patients who had progressed ≤6 months before enrollment, potentially accounting for the low response rates.See related commentary by Wilky and Maleddu, p. 1163