bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydroxypropyl cellulose/Polyvinylpyrrolidone Matrix Tablets Containing Ibuprofen: Infiltration, Erosion and Drug Release Characteristics
Authors: Erkoç Tuğba , Sevgili Lutfullah M. , Çavuş Selva 
Published: August 2022

AbstractThe current study aims to prepare the matrix tablet including polyvinylpyrrolidone (PVP), hydroxypropyl cellulose (HPC) and poorly water‐soluble ibuprofen (IBU) and to investigate the effect of varying polymer compositions on infiltration of the aqueous medium, erosion kinetics, swelling and drug release. Swelling, infiltration and erosion studies were performed gravimetrically at pH 7.4 at 37±0.1 °C. Drug release experiments were carried out at 37± 0.1 °C with 50 rpm in phosphate buffer solution (pH 7.4). The effect of sodium dodecyl sulfate (SDS) on drug release as an anionic surfactant was also investigated. Hixson‐Crowell kinetic model was found to best fit for matrix tablet in phosphate buffer solution (pH 7.4) for HPC80‐IBU100‐PVP20 and ibuprofen release % was observed as 99.5 within 24 hours. Weibull model showed that HPC80‐IBU100‐PVP20 matrix provided slower drug release and the highest time values (t50%=7.3 h and t90%=17.3 h) were obtained. Thermal gravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD) and differential scanning calorimetry (DSC) techniques were used in the characterization studies.
1,3‐Dipolar versus Nucleophilic Reactivity of Diaziridines Based on 3,4‐Dihydroisoquinoline toward Aryl Iso(thio)cyanates
Authors: Penney Alexander A. , Efremova Mariia M. , Molchanov Alexander P. , Kryukova Mariya A. , Kudinov Andrey Yu. , Bunev Alexander S. , Keresten Valentina M. , Kuznetsov Mikhail A. 
Published: August 2022

AbstractUnsubstituted and 1‐methyl‐substituted 1,3,4,8b‐tetrahydrodiazirino[3,1‐a]isoquinolines (diaziridines 1 and 2) demonstrate different reactivities toward aryl isocyanates and aryl isothiocyanates. Diaziridine 1 reacts with aryl isocyanates as a nucleophile to afford novel 1,5,6,10b‐tetrahydro[1,2,4]triazolo[5,1‐a]isoquinolines. The addition of a Lewis or Brønsted acid switches the reaction pathway, producing seven‐membered 2,3‐benzodiazepines. In reactions of diaziridine 1 with aryl isothiocyanates, unusual zwitterionic compounds – 2‐thioxo‐5,6‐dihydro‐2H‐[1,2,4]triazolo[5,1‐a]isoquinolin‐1‐ium‐3‐ides – and products of the addition of two molecules of diaziridine 1 to one molecule of aryl isothiocyanate are obtained. However, in reactions with aryl iso(thio)cyanates under heating or acid catalysis, diaziridine 2 is first converted into an azomethine imine, the 1,3‐dipolar cycloaddition of which to the dipolarophile produces substituted triazolo[5,1‐a]isoquinolin‐2(3H)‐(thi)ones. Proposed is a new method for azomethine imine generation from diaziridine 2 enabled by Brønsted acid catalysis. Antitumour activity of select compounds obtained was assayed to help guide future drug discovery efforts.
Evolution of filter‐feeding in aquatic insects dates back to the Middle Triassic: new evidence from stem‐group mayflies (Insecta, Ephemerida) from Grès à Voltzia, Vosges, France
Authors: Sroka Pavel , Staniczek Arnold H. 
Published: August 2022

AbstractIn the aquatic insects, mayfly nymphs have developed a remarkable diversity of life strategies and feeding habits. However, the early evolution of these strategies and the role of mayfly nymphs in freshwater palaeoecosystems remain largely unknown. We investigated fossil mayfly nymphs from the Grès à Voltzia Formation from the Middle Triassic, France, which represents the oldest known outcrop yielding a diverse mayfly fauna. We focused on three species, namely Mesoplectopteron longipes, Vogesonympha ludovici and Triassoephemera punctata, and investigated both original type material and numerous previously unstudied specimens. As a result, we provide a new interpretation of their morphology, life histories, and systematics: the nymphs of M. longipes, V. ludovici and T. punctata were aquatic and at least the former two species undoubtedly lived in flowing water as passive filter‐feeders. This finding represents the so far earliest occurrence of this feeding strategy in aquatic insects. The most obvious morphological adaptations to this lifestyle are long filtering setae arranged in rows on forelegs, analogous to some modern mayfly nymphs. We place the three investigated species M. longipes, V. ludovici and T. punctata in a newly established, unranked higher taxon, Sinebranchia, representing the sister group to Heptabranchia (Coxoplectoptera + Ephemeroptera). Sinebranchia share a single‐segmented tarsus synapomorphic with Heptabranchia, but retain the plesiomorphic condition of double tarsal claws. Sinebranchia are also characterized by their autapomorphic lack of tracheal gills, probably connected to their life in flowing, well‐oxygenated water.
Load‐bearing capacity of Gerber saddles in existing bridge girders by different levels of numerical analysis
Authors: Spinella Nino , Messina Davide 
Published: August 2022

AbstractThis paper numerically investigates three typologies of Gerber saddle in existing ordinary and post‐tensioned girder concrete bridges. The main goals of this work concern the evaluation of the effective load‐bearing capacity of Gerber saddles, and the identification of weak points (i.e., lack of enough diagonal reinforcement, loss of pretension in tendons) of existing dapped‐end connections, which lead to the re‐entrant corner diagonal crack, typical of these kinds of structural elements. At this aim, two analytical approaches, with different level of approximations, are used. First, different strut‐and‐tie models are arranged for each typology of Gerber saddle considered, and the global safety factor is estimated for several cases. Second, using nonlinear finite‐element method, the results obtained by strut‐and‐tie models are compared. In addition, several information about the condition of Gerber saddle at collapse are obtained (deformation and stress of concrete and steel rebar, crack patterns) also taking into account the corrosion‐damage effects. Moreover, the results of analyses allow identifying the potential modes of crisis of the dapped‐end connections and their critical aspects.
Lattice study of a magnetic contribution to heavy quark momentum diffusion
Authors: Banerjee D. , Datta S. , Laine M. 
Published: August 2022

Abstract
Heavy quarks placed within a hot QCD medium undergo Brownian motion, characterized by specific transport coefficients. Their determination can be simplified by expanding them in T/M, where T is the temperature and M is a heavy quark mass. The leading term in the expansion originates from the colour-electric part of a Lorentz force, whereas the next-to-leading order involves the colour-magnetic part. We measure a colour-magnetic 2-point correlator in quenched QCD at T ∼ (1.2 − 2.0)Tc. Employing multilevel techniques and non-perturbative renormalization, a good signal is obtained, and its continuum extrapolation can be estimated. Modelling the shape of the corresponding spectral function, we subsequently extract the momentum diffusion coefficient, κ. For charm (bottom) quarks, the magnetic contribution adds ∼ 30% (10%) to the electric one. The same increases apply also to the drag coefficient, η. As an aside, the colour-magnetic spectral function is computed at NLO.
Feynman’s iϵ prescription, almost real spacetimes, and acceptable complex spacetimes
Authors: Visser Matt 
Published: August 2022

Abstract
Feynman’s iϵ prescription for quantum field theoretic propagators has a quite natural reinterpretation in terms of a slight complex deformation of the Minkowski space-time metric. Though originally a strictly flat-space result, once reinterpreted in this way, these ideas can be naturally extended first to semi-classical curved-spacetime QFT on a fixed background geometry and then, (with more work), to fluctuating spacetime geometries. There are intimate connections with variants of the weak energy condition. We shall take the Lorentzian signature metric as primary, but note that allowing the complex deformation to become large leads to a variant of Wick rotation, and more importantly leads to physically motivated constraints on the configuration space of acceptable off-shell geometries to include in Feynman’s functional integral when attempting to quantize gravity. Ultimately this observation allows one to connect the discussion back to recent ideas on “acceptable” complex metrics, in the Louko-Sorkin and Kontsevich-Segal-Witten sense, with Lorentzian signature spacetimes occurring exactly on the boundary of the set of “acceptable” complex metrics. By adopting the tetrad formalism we explicitly construct the most general set of acceptable complex metrics satisfying the 0-form, 1-form, and 2-form acceptability conditions.
Outcomes of acetabular fractures treated with acute fix and replace versus open reduction and internal fixation in elderly population: a multicentric retrospective study
Authors: Smakaj Amarildo , Rovere Giuseppe , Scoscina Dalila , De Mauro Domenico , Erasmo Rocco , Battiato Concetto , Maccauro Giulio , Liuzza Francesco 
Published: August 2022

Abstract
Purpose
The optimal operative treatment for displaced acetabular fractures in elderly population is still object of debate. Acute fix and replace procedure, the so called “combined hip procedure” (CHP), was introduced because of the poor results of the open reduction and internal fixation (ORIF) alone. The aim of the study is to compare clinical outcomes of CHP and ORIF alone for the treatment of acetabular fractures in elderly patients.

Methods
This is the largest multicentric retrospective analytical study, with a case–control design on the issue. Hospital records and clinical notes were reviewed to collect demographic, peri-operative, and clinical data.

Results
A total of 45 patients met the inclusion criteria: 24 patients entered the CHP group whereas 21 entered the ORIF control group. The mean age was 69.5 +  − 1.12 years in the ORIF group and 73.4 +  − 1.84 in the control group. The most frequent traumatic mechanism was the fall from same level in both groups (37.5% CHP; 42.9% ORIF). Operating time was significantly lower in the CHP group compared to the ORIF group (207 +  − 11.0 ORIF; 175 +  − 9.16 CHP; p < 0.05). Moreover, full weight-bearing was allowed significantly earlier in the CHP group compared to ORIF alone (37.3 +  − 1.59 ORIF; 32.5 +  − 1.69 CHP; p < 0.05). Among the clinician-completed scores, the HHS at three months was higher in the CHP group (66.3 +  − 1.83 ORIF;73.6 +  − 2.09 CHP; p < 0.05). All the other clinical outcomes were similar in both study groups.

Conclusion
CHP is desirable treatment option in elderly patients with acetabular fracture when there are poor expected outcomes in terms of joint survival with ORIF alone.
Relationship between non-invasively detected liver fibrosis and in-hospital outcomes in patients with acute coronary syndrome undergoing PCI
Authors: Biccirè Flavio Giuseppe , Barillà Francesco , Sammartini Emanuele , Dacierno Edoardo Maria , Tanzilli Gaetano , Pastori Daniele 
Published: August 2022

Abstract
Background
Patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) still experience a high rate of in-hospital complications. Liver fibrosis (LF) is a risk factor for mortality in the general population. We investigated whether the presence of LF detected by the validated fibrosis 4 (FIB-4) score may indicate ACS patients at higher risk of poor outcome.

Methods
In the prospective ongoing REAl-world observationaL rEgistry of Acute Coronary Syndrome (REALE-ACS), LF was defined by a FIB-4 score > 3.25. We repeated the analysis using an APRI score > 0.7. The primary endpoint was in-hospital adverse events (AEs) including a composite of in-hospital cardiogenic shock, PEA/asystole, acute pulmonary edema and death.

Results
A total of 469 consecutive ACS consecutive patients were enrolled. Overall, 21.1% of patients had a FIB-4 score > 3.25. Patients with LF were older, less frequently on P2Y12 inhibitors (p = 0.021) and admitted with higher serum levels of white blood cells (p < 0.001), neutrophils to lymphocytes ratio (p < 0.001), C-reactive protein (p = 0.013), hs-TnT (p < 0.001), creatine-kinase MB (p < 0.001), D-Dimer levels (p < 0.001). STEMI presentation and higher Killip class/GRACE score were more common in the LF group (p < 0.001). 71 patients experienced 110 AEs. At the multivariate analysis including clinical and laboratory risk factors, FIB-4 > 3.25 (OR 3.1, 95%CI 1.4–6.9), admission left ventricular ejection fraction% below median (OR 9.2, 95%CI 3.9–21.7) and Killip class ≥ II (OR 6.3, 95%CI 2.2–18.4) were the strongest independent predictors of in-hospital AEs. Similar results were obtained using the APRI score.

Conclusion
LF detected by FIB-4 score > 3.25 was associated with more severe ACS presentation and worse in-hospital AEs irrespective of clinical and laboratory variables.

Graphical abstract
Fibroblast activation protein in the tumor microenvironment predicts outcomes of PD-1 blockade therapy in advanced non-small cell lung cancer
Authors: Zhao Yan , Liu Yueping , Jia Yunlong , Wang Xiaoxiao , He Jiankun , Zhen Shuman , Wang Jiali , Liu Lihua 
Published: August 2022

Abstract
Purpose
The identification of robust predictive biomarkers of the response to programmed cell death-1 (PD-1) blockade remains a critical concern. Here, we investigated on fibroblast activation protein (FAP) as a microenvironment-derived biomarker of clinical outcomes of PD-1 blockade therapy, and the correlation between FAP expression and T cell infiltration in advanced non-small cell lung cancer (NSCLC).

Methods
A total of 135 patients with advanced NSCLC who received PD-1 blockade therapy were retrospectively analyzed. The potential associations among FAP expression, CD3 + T cell and CD8 + T cell infiltration, and clinical outcomes of immunotherapy were validated by immunohistochemistry, bioinformatic analyses, and statistical measurements.

Results
FAP was widely expressed in advanced NSCLC tissues. FAP was correlated with decreased density of CD8 + T cells (Spearman’s rho  – 0.32, p < 0.001) and immunosuppressive tumor microenvironment (TME) status. No correlations were detected between FAP and PD-L1 expression or with the density of CD3 + T cells. The patients with higher expression of FAP showed worse response rate (16.4% vs. 38.7%, p < 0.001) and worse progression-free survival (HR = 2.56, 95% CI 1.69–3.87, p < 0.001). In addition, FAP contributed to shortened overall survival in subgroups of the patients with squamous cell lung cancer (p = 0.020), PD-1 blockade monotherapy (p = 0.017), and first-line therapy (p = 0.028).

Conclusion
FAP is a potential predictive biomarker of resistance to PD-1 blockade. Further investigation is warranted to identify a strategy for targeting FAP to alleviate the immunosuppressive TME and broaden the clinical effectiveness of PD-1 blockade therapy.
Early-succession secondary forests following agropastoral abandonment are key winter habitats for the conservation of a priority bird in the European Alps
Authors: Scridel D. , Tenan S. , Brambilla M. , Celva R. , Forti A. , Fracasso I. , Volcan G. , Dorigatti E. , Anderle M. , Marchesini A. , Crestanello B. , Vernesi C. , Pedrini P. , Partel P. 
Published: August 2022

AbstractIn contrast to old-growth forests, early-successional stands remain understudied despite potentially harbouring species of conservation interest. With this work, focused on hazel grouse Tetrastes bonasia, a cryptic and indicator species known to select for close-to-natural forests, we evaluated winter densities, home range, microhabitat selection and diet, combining DNA-based mark-recapture and metabarcoding from faecal samples. In total, 216 droppings, collected over 2 years along forest transects in the Italian Alps, were successfully genotyped and 43 individuals were identified. Density estimates were similar to values reported by other studies in the Alps with an average of 4.5 and 2.4 individuals/km2 in the first and second study year, respectively, and mean home ranges estimated at 0.95 km2. According to habitat selection models and eDNA-based diet analysis, hazel grouse selected early-succession secondary-growth forests formed after the abandonment of traditional agropastoral activities. These forests, mostly composed of hazel Corylus avellana, Norway spruce Picea abies and Sorbus spp., provided winter food resources and shelter. The diet analysis also highlighted forest arthropods as a non-negligible source of food. Birds avoided areas subject to intensive browsing by ungulates; small forest roads seasonally closed to traffic had positive influence on hazel grouse (i.e. higher abundance of droppings), while roads open to traffic had no effect. Importantly, despite the high coverage of mature forest habitats of Community Interest (53% of our study area), droppings were more abundant in non-listed early-succession secondary forests with similar plant composition. Our results suggest that forest succession after agropastoral abandonment may be beneficial for some forest birds of conservation interest, while acknowledging its negative effects on the previous grassland biodiversity.
Graphical abstract
HybridRec: A recommender system for tagging GitHub repositories
Authors: Di Rocco Juri , Di Ruscio Davide , Di Sipio Claudio , Nguyen Phuong T. , Rubei Riccardo 
Published: August 2022

AbstractSoftware repositories are increasingly essential to support the management of typical artifacts building up projects, including source code, documentation, and bug reports. GitHub is at the forefront of this kind of platforms, providing developer with a reservoir of code contained in more than 28M repositories. To help developers find the right artifacts, GitHub uses topics, which are short texts assigned to the stored artifacts. However, assigning inappropriate topics to a repository might hamper its popularity and reachability. In our previous work, we implemented MNBN and TopFilter to recommend GitHub topics. MNBN exploits a stochastic network to predict topics, while TopFilter relies on a syntactic-based function to recommend topics. In this paper, we extend our work by building HybridRec, a recommender system based on stochastic and collaborative-filtering techniques to generate more relevant topics. To deal with unbalanced datasets, we employ a Complement Naïve Bayesian Network (CNBN). Furthermore, we apply a preprocessing phase to clean and refine the input data before feeding the recommendation engine. An empirical evaluation demonstrates that HybridRec outperforms three state-of-the-art baselines, obtaining a better performance with respect to various metrics. We conclude that the conceived framework can be used to help developers increase their projects’ visibility.
Where ecologically ‘tis better to go brown than green: enhanced seagrass macrobenthic biodiversity within the canals of a brownfield coastal marina
Authors: Barnes Richard S.K , Claassens Louw , Seath Jessica 
Published: August 2022

AbstractAt the start of the 21st century, a coastal residential-estate marina was developed on a previously degraded and polluted brownfield island site within Knysna estuarine bay, Garden Route National Park, South Africa, including the creation of 25 ha of new flow-through tidal canals. Canals near the larger entrance to this system now support permanently submerged beds of seagrass, which in turn support abundant macrobenthic invertebrates. In comparison with equivalent seagrass-associated assemblages present in natural channels around the island, those in the artificial marina canals were similarly structured and dominated by the same species, but the marina assemblages were significantly more species-rich (1.4 x on average) and were more abundant. Indeed, this area of marina supports the richest seagrass-associated macrofaunal biodiversity yet recorded from South Africa. The canals created de novo therefore now form a valuable addition to the bay’s marine habitat, in marked contrast to the generality that marinas developed on greenfield sites represent a net reduction in intertidal and shallow marine area and associated seagrass-associated benthos. If located and constructed appropriately, brownfield marina development and conservation of coastal marine biodiversity clearly need not be antithetical, and brownfield sites may provide opportunity for the location and management of ‘artificial marine micro-reserves’ or for the action of ‘other effective area-based conservation measures’ for soft-sediment faunas.
Improving Children’s Behavior in Seven Sessions: A Randomized Controlled Trial of Parent-Child Care (PC-CARE) for Children Aged 2–10 Years
Authors: Hawk Brandi N. , Timmer Susan G. , Armendariz Lindsay A. F. , Boys Deanna K. , Urquiza Anthony J. , Fernández y Garcia Erik 
Published: August 2022

AbstractParent-Child Care (PC-CARE) is a brief intervention for children with externalizing behaviors designed to address issues with their access to and retention in treatment. A growing evidence base of open trials and comparison studies support PC-CARE’s benefits, but no randomized controlled trials (RCTs) of its effectiveness exist. The current study presents the first RCT of PC-CARE, a 7-session dyadic parenting intervention (trial number removed for blind review). Participants included a racially/ethnically diverse sample of 49 children (29% female) aged 2–10 years and their caregivers. Participants were randomly assigned to PC-CARE or waitlist control. Families participating in PC-CARE showed greater reductions in children’s externalizing behaviors, improvements in children’s adaptive skills, declines in parental stress, and increases in parents’ positive communication skills, compared to families on the waitlist. The results of this first RCT of PC-CARE support the effectiveness of this brief intervention in improving children’s behaviors.
Ancestor simulations and the Dangers of Simulation Probes
Authors: Braddon-Mitchell David , Latham Andrew J. 
Published: August 2022

AbstractPreston Greene (2020) argues that we should not conduct simulation investigations because of the risk that wemight be terminated if our world is a simulation designed to research various counterfactuals about the world of the simulators. In response, we propose a sequence of arguments, most of which have the form of an "even if? response to anyone unmoved by our previous arguments. It runs thus: (i) if simulation is possible, then simulators are as likely to care about simulating simulations as they are likely to care about simulating basement (i.e. nonsimulated) worlds. But (ii) even if simulations are interested only in simulating basement worlds the discovery that we are in a simulation will have little or no impact on the evolution of ordinary events. But (iii) even if discovering that we are in a simulation impacts the evolution of ordinary events, the effects of seeming to do so could also happen in a basement world, and might be the subject of interesting counterfactuals in the basement world. Finally, (iv) there is little reason to think that there is a catastrophic effect from successful simulation probes, and no argument from the precautionary principle can be used to leverage the negligible credence one ought have in this. Thus, if we do develop a simulation probe, then let?s do it.