bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumor growth ameliorates cardiac dysfunction
Authors: Awwad Lama , Shofti Rona , Haas Tali , Aronheim Ami 
Published: December 2022

Abstract

Heart failure and cancer are the leading cause of deaths worldwide. The diseases share common risk factors, survival pathways and death signals. Recent studies suggest that these diseases are highly connected and affect each other outcome. Murine models for cardiac remodeling and heart failure including: myocardial infraction, pressure overload, cardiac hypertrophy, and chronic hypertension promotes cancer progression and metastasis spread. In addition, heart failure patients have increased risk to develop cancer. Nevertheless, no information is available whether and how tumor progression affects cardiac remodeling. Here we examined cardiac remodeling processes in the presence and absence of tumor. We show that tumor-bearing mice display reduced cardiac hypertrophy, lower fibrosis, and improved cardiac contractile function. While the adaptive immune system is not involved, we found that innate immune cells play a major role. We identified that the cardiac macrophage population undergoes tumor dependent M1 to M2 polarization. Importantly, tumor-bearing mice lacking functional macrophages fail to improve cardiac function and display sustained fibrosis. This is the first study showing the double-edged sword interaction between cancer and heart failure. While heart failure promotes tumor growth, cancer improves cardiac outcome. Harnessing cancer paradigms that are involved in the tumor to heart beneficial outcome may provide novel therapeutics strategies for cardiovascular diseases.
Spatial inequality in safely managed water access in Ghana
Authors: Dongzagla Alfred , Dordaa Felix , Agbenyo Fauster 
Published: December 2022

Abstract
This paper examines inequalities in drinking water access among regions and between urban and rural areas in Ghana with a focus on access to safely managed water service, access to safe water, access to water on premises, access to sufficient quantities of water, and access to improved water. Microdata of the 2017/18 Ghana Multiple Indicator Cluster Survey was used and analyzed using descriptive statistics and Gini index. Nationally, access to safely managed water service was low (6.8%) with moderate inequality among regions (Gini index = 0.27) and high inequality between rural and urban areas (Gini index = 0.42). Among the 10 administrative regions, moderate inequality was recorded for access to water on premises (Gini index = 0.20), and low inequality for access to safe water (Gini index = 0.117), access to improved water (0.06), and access to sufficient quantities of drinking water (0.02). The results of the study reinforce the call by the United Nations for disaggregation of national data of the Sustainable Development Goals by relevant socio-economic and spatial variables at a subnational level to help in the design and implementation of inclusive and equitable policies.
Application of encapsulated and immobilized nano zero-valent iron for iron removal from roof-harvested rainwater
Authors: Antony Jismy , V. Meera , Raphael Vinod P. , P. Vinod 
Published: December 2022

Abstract
Rainwater harvesting is a viable option for dealing with the global challenge of increasing water scarcity, but heavy metal contamination often prevents it from being widely used for drinking water purposes. Harvested rainwater collected from galvanized iron (GI) and tile roofs containing iron concentration of 0.46 and 0.38 mg/L respectively, were treated by two nano sorbents, CaCO3-nZVI and PUF/CaCO3-nZVI with the intention of making the iron concentration conform to drinking quality standards. The nano sorbents were synthesized and characterized using BET (Brunauer-–Emmett–Teller surface area), SEM-EDX (Scanning Electron Microscopy-Energy-Dispersive X-ray spectroscopy, and FTIR (Fourier Transform Infrared Spectroscopy). CaCO3-nZVI achieved iron removal efficacy of 88.69% and 89.21% for harvested rainwater from GI sheet roof and tiled roof respectively and the efficiency increased to 95.65% and 95.78% when treated with PUF/CaCO3-nZVI. In addition, the nano sorbents were found to have appreciable removal efficiency for other metals (Pb, Mn, Zn, Cu, Cd and Cr) present in the collected rainwater. The use of FTIR and EDX to characterise spent nano sorbents divulged that the iron was removed through sorption process. This study thus explored the potential of CaCO3-nZVI and PUF/CaCO3-nZVI for treating heavy metal contamination in roof-harvested rainwater.
Understanding the Potential Function of Perivascular Adipose Tissue
in Abdominal Aortic Aneurysms: Current Research Status and
Future Expectation
Authors: Liu Xi-Yan , Wen Tao , Wu Ze-Fan , Deng Nian-Hua , Liu Hui-Ting , Ren Zhong , Xiong Wen-Hao , Jiang Zhi-Sheng 
Published: December 2022

Abstract:
An abdominal aortic aneurysm (AAA) is a progressive dilatation of the vascular
wall occurring below the aortic fissure, preferably occurring below the renal artery.
The molecular mechanism of AAA has not yet been elucidated. In the past few decades,
research on abdominal aortic aneurysm has been mainly focused on the vessel wall, and
it is generally accepted that inflammation and middle layer fracture of the vessel wall is
the core steps in the development of AAA. However, perivascular adipose tissue plays a
non-negligible role in the occurrence and development of AAA. The position of PVAT
plays a supporting and protective role on the vascular wall, but the particularity of the location
makes it not only have the physiological function of visceral fat; but also can regulate
the vascular function by secreting a large number of adipokines and cytokines. An abdominal
aortic aneurysm is getting higher and higher, with a vascular rupture, low rescue
success rate, and extremely high lethality rate. At present, there is no drug to control the
progression or reverse abdominal aortic aneurysm. Therefore, it is critical to deeply explore
the mechanism of abdominal aortic aneurysms and find new therapeutic ways to inhibit
abdominal aortic aneurysm formation and disease progression. An abdominal aortic
aneurysm is mainly characterized by inflammation of the vessel wall and matrix metalloprotein
degradation. In this review, we mainly focus on the cytokines released by the perivascular
adipose tissue, summarize the mechanisms involved in the regulation of abdominal
aortic aneurysms, and provide new research directions for studying abdominal aortic
aneurysms.
Design, Synthesis, Molecular Docking, Dynamics and in vitro Evaluation of Novel 2-substituted-1-hydroxyethane-1, 1-bis(phosphonic acid) Derivatives as Human Farnesyl Pyrophosphate Synthase Inhibitors with Expected Anticancer Activity
Authors: Khedr Mohammed A. , Al-Wabli Reem I. , Almutairi Maha S. , Zaghary Wafaa A. 
Published: December 2022

Background:
Nitrogenous bisphosphonates (NBPs) are the major class of drugs that are used to treat
osteoporosis. Recently, bisphosphonates (BPs) were reported to have an anticancer effect. These agents feature
a high affinity that enables them to bind strongly to the human farnesyl pyrophosphate synthase enzyme. The
correlation between this affinity and their anticancer effect was confirmed.

Objective:
To date, the use of an oxygen atom as an isosteric replacement for the electronegative nitrogen atom
in NBPs has not been reported, and its ability to retain the linker length and bisphosphonate pharmacophore remains
unknown. The main aim of this work was to design some isosteric bisphosphonate analogs with oxygen
atoms and evaluation of their binding affinity and anticancer activity.

Methods:
The binding mode and stability of the designed compounds were achieved using human farnesyl pyrophosphate
synthase (HFPPS) by docking and dynamic simulations. The compounds were synthesized, characterized,
and screened for their anticancer activity against the breast cancer MCF-7 cell line and lung cancer
A-549 cell line. The inhibitory activity of the tested compounds against HFPPS was evaluated.

Results:
The compounds under investigation showed potential anticancer activity against the lung cell line with
IC50 values of 41.7, 47.4, and 34.8 μg/ml in comparison to that of Risedronic acid (115 μg/ml). However, they
do not exhibit potential activity against the breast cancer cell line.

Conclusion:
Compounds VII and VIII showed in vitro inhibition of human farnesyl pyrophosphate synthase
with IC50 values of 82.2 and 98.8 μg/ml, respectively. Further optimization may be required in the future.
Marine-derived Natural Products as Anticancer Agents
Authors: Saini Nancy , Sirohi Ritika , A. Anuradha , Saini Neetu , Wadhwa Pankaj , Kaur Paranjeet , Sharma Vikas , Singh Gurdeep , Singh Iqubal , Sahu Sanjeev Kumar 
Published: December 2022

Abstract:
Cancer is a deadly human disease on the rise due to changes in lifestyle, nutrition, and
global warming. Cancer is characterized by uncontrolled, disordered, and undesired cell division.
About 60% of cancer medicines approved by the FDA are made from natural ingredients. Intensive
efforts over the last decade to better understand the vast chemical diversity provided by marine life
have resulted in an intriguing "marine pipeline" of potential anticancer clinical and preclinical treatments.
The molecular targets of marine products as anticancer drugs, as well as different reported
compounds acting on distinct targets, are the topic of this review.
Synthesis, Biological Evaluation, and Docking Studies of Open-Chain
Carbohydrate Amides as Acetylcholinesterase Inhibitors
Authors: Gonçalves-Pereira Rita , Figueiredo Jose A. , Lucas Susana D. , García-Moreno Maria I. , Mellet Carmen O. , Rauter Amelia P. , Ismael Maria I. 
Published: December 2022

Introduction:
Alzheimer’s disease is a multifactorial syndrome, which is not yet fully
understood, causing memory loss, dementia, and, ultimately, death. Acetylcholinesterase inhibitors
are the mainstay drugs that are used in disease-symptomatic treatment. In this work, we report a new
synthetic route yielding sugar amides as low to moderate acetylcholinesterase inhibitors.

Methods:
Commercially available diacetone glucose was converted into perbenzyl D-glucono-1,4-
lactone, which reacted with aromatic or aliphatic amines to afford the corresponding new amides in a
high isolated yield. Docking studies of the most promising hydroxybutylamide and benzylamide
were performed to assign binding interactions with acetylcholinesterase and determine the key features
for bioactivity.

Results:
The inhibitors are accommodated in enzyme gorge, blocking the access to Ser203 mainly
due to π-π stacking interactions of sugar benzyl groups with the aromatic gorge residues, Tyr337 and
Tyr341 for both inhibitors and Trp439 only for the hydroxybutylamide.

Conclusion:
Bonding is also significant through sugar interaction with the residues Tyr124 and
Ser125-OH in both inhibitors. Flexibility of these open-chain structures seems to be quite relevant
for the observed binding to acetylcholinesterase.
An In-silico Multi-Targeted Approach in Search of Potential Drug Candidate(
s) Against SARS-CoV-2 Lung Infection
Authors: Pradhan Joohee , Kapoor Kapish , Das Vishnu , Bhatnagar Ayushi , Panchawat Sunita 
Published: December 2022

Background:
The multitargeted computational approach for the design of drugs to treat severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lung infection from herbal sources may lead to
compound(s) that is/are safe (derived from natural sources), effective (act on predefined targets) and
broad spectrum (active in both, adult and juvenile population).

Objective:
The present work aims at developing a specific and effective treatment for a lung infection in
both the adult and juvenile population, caused due to SARS-CoV-2 through a computational approach.

Methods:
A systematic virtual screening of 27 phytoconstituents from 11 Indian herbs with antiviral, antiinflammatory,
and immunomodulatory activity was performed. After applying the Lipinski rule of five,
19 compounds that fitted well were subjected to molecular docking studies using Molegro virtual docker
6.0 with two targets viz. SARS-CoV-2 main protease (Mpro) (PDB ID 6LU7) and ACE receptor (PDB ID
6M0J). The best-docked complexes were used to develop a merged feature pharmacophore using Ligandscout
software, to know the structural requirements to develop multitarget inhibitor(s) of SARS-CoV-
2. Drug likeliness and ADMET studies were also performed.

Results:
The results revealed that Syringin, a glycoside from Tinospora cordifolia, has a good binding
affinity towards both targets as compared to Remdesivir. Furthermore, drug likeliness and ADMET studies
established its better bioavailability and low toxicity.

Conclusion:
The pharmacophores developed from protein-ligand complexes provided an important understanding
to design multitarget inhibitor(s) of SARS-CoV-2 to treat COVID-19 lung infection in both
the adult and juvenile populations. Syringin may be subjected to further wet-lab studies to establish the
results obtained through in-silico studies.
Examining the Utility of a Telehealth Warm Handoff in Integrated Primary Care for Improving Patient Engagement in Mental Health Treatment: Randomized Video Vignette Study
Authors: Fountaine Alex R , Iyar Megumi M , Lutes Lesley D 
Published: December 2022

Background
A warm handoff from a physician to a mental health provider is often patients’ first contact with psychological services and provides a unique opportunity for improving treatment engagement in integrated primary care (IPC) settings.

Objective
In light of the COVID-19 pandemic, this study sought to examine the impact of different types of telehealth mental health referrals on both the anticipated likelihood of accepting treatment services and anticipated likelihood of continued treatment engagement.

Methods
A convenience sample of young adults (N=560) was randomized to view 1 of 3 video vignettes: warm handoff in IPC, referral as usual (RAU) in IPC, or RAU in standard primary care.

Results
Logistic associations between referral type and the likelihood of referral acceptance (χ21=10.9, P=.004) and the likelihood of continued engagement (χ21=32.6, P<.001) were significant. Participants who received a warm handoff were significantly more likely to anticipate both accepting the referral (b=0.35; P=.002; odds ratio 1.42, 95% CI 1.15-1.77) and engaging in continued treatment (b=0.62; P<.001; odds ratio 1.87, 95% CI 1.49-2.34) compared with those who received RAU in the standard primary care condition. Furthermore, 77.9% (436/560) of the sample indicated that they would be at least somewhat likely to access IPC mental health services for their own mental health concerns if they were readily available in their own primary care physician’s office.

Conclusions
A telehealth warm handoff resulted in the increased anticipated likelihood of both initial and continued engagement in mental health treatment. A telehealth warm handoff may have utility in fostering the uptake of mental health treatment. Nonetheless, a longitudinal assessment in a primary care clinic of the utility of a warm handoff for fostering referral acceptance and continued treatment engagement is needed to hone the adoptability of a warm handoff process and demonstrate practical evidence of effectiveness. The optimization of a warm handoff would also benefit from additional studies examining patient and provider perspectives about the factors affecting treatment engagement in IPC settings.
When Heart Beats Differently in Depression: Review of Nonlinear Heart Rate Variability Measures
Authors: Čukić Milena , Savić Danka , Sidorova Julia 
Published: December 2022

Background
Disturbed heart dynamics in depression seriously increases mortality risk. Heart rate variability (HRV) is a rich source of information for studying this dynamics. This paper is a meta-analytic review with methodological commentary of the application of nonlinear analysis of HRV and its possibility to address cardiovascular diseases in depression.

Objective
This paper aimed to appeal for the introduction of cardiological screening to patients with depression, because it is still far from established practice. The other (main) objective of the paper was to show that nonlinear methods in HRV analysis give better results than standard ones.

Methods
We systematically searched on the web for papers on nonlinear analyses of HRV in depression, in line with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 framework recommendations. We scrutinized the chosen publications and performed random-effects meta-analysis, using the esci module in jamovi software where standardized effect sizes (ESs) are corrected to yield the proof of the practical utility of their results.

Results
In all, 26 publications on the connection of nonlinear HRV measures and depression meeting our inclusion criteria were selected, examining a total of 1537 patients diagnosed with depression and 1041 healthy controls (N=2578). The overall ES (unbiased) was 1.03 (95% CI 0.703-1.35; diamond ratio 3.60). We performed 3 more meta-analytic comparisons, demonstrating the overall effectiveness of 3 groups of nonlinear analysis: detrended fluctuation analysis (overall ES 0.364, 95% CI 0.237-0.491), entropy-based measures (overall ES 1.05, 95% CI 0.572-1.52), and all other nonlinear measures (overall ES 0.702, 95% CI 0.422-0.982). The effectiveness of the applied methods of electrocardiogram analysis was compared and discussed in the light of detection and prevention of depression-related cardiovascular risk.

Conclusions
We compared the ESs of nonlinear and conventional time and spectral methods (found in the literature) and demonstrated that those of the former are larger, which recommends their use for the early screening of cardiovascular abnormalities in patients with depression to prevent possible deleterious events.
A Case of Misplaced Concreteness?
Authors: Bracken Joseph A. 
Published: December 2022

Abstract
The author argues that, while logical rigor requires Whiteheadians to emphasize the ontological priority of the notion of actual entity as a selfconstituting subject of experience for the proper understanding of physical reality, Whitehead’s understanding of the key category of society in his metaphysics, especially the way that societies and their constituent actual entities reciprocally "constrain" one another’s existence and activity (PR 90-91) and the way that societies are hierarchically ordered to one another within the evolutionary process (PR 99-103) will presumably have more empirical resonance with natural scientists in their own efforts to understand the emergence of life from non-life, the progressive growth of self-awareness among higher-order animal species, etc. So, in dialogue with natural scientists, why not start with what is psychologically more interesting to the listener?
Judaism, Process Theology, and Formal Axiology: A Preliminary Study
Authors: Edwards Rem B. 
Published: December 2022

Abstract
This article approaches Judaism through Rabbi Bradley S. Artson’s book, God of Becoming and Relationships: The Dynamic Nature of Process Theology. It explores his understanding of how Jewish theology should and does cohere with central features of both process theology and Robert S. Hartman’s formal axiology. These include the axiological/process concept of God, the intrinsic value and valuation of God and unique human beings, and Jewish extrinsic and systemic values, value combinations, and value rankings.
Whiteheadian Metaphysics, General Relativity, and String Theory
Authors: Bracken Joseph A. 
Published: December 2022

Abstract
String theory is often depicted as the best chance for natural science to find a Theory of Everything. Whiteheadians may object that only a philosophical cosmology such as Whitehead presents in PR can "frame a coherent, logical, necessary system of general ideas in terms of which every element of our experience can be interpreted" (PR 3). But then they have to show that Whitehead’s scheme and string theory fit together nicely, with each helping to resolve residual problem areas in the other. The present article conjectures that the tiny vibrating strings postulated by string theory and the superjects of individual actual entities might correspond to the "final, real things of which the world is made up" (PR 18). Likewise, the extra spatial dimensions required by the mathematics of string theory might be more intelligible in terms of the interaction of different levels of subsocieties within a Whiteheadian structured society.
The Sense of Symmetry: Comparative Reflections on Whitehead, Nishida, and Dōgen
Authors: Ishida Masato 
Published: December 2022

Abstract
In contrast to temporal asymmetry stressed in process philosophy, symmetry prevails in Mahayana Buddhism and East Asian philosophy formed under its influence. The paper clarifies the meaning of symmetry from the perspectives of Kitaro Nishida and Dogen, it explores similar or overlapping ideas in Whitehead’s philosophy of organism, and it suggests that the differences among them are much smaller than commonly believed.
GOD AS A SINGLE PROCESSING ACTUAL ENTITY
Authors: Edwards Rem B. 
Published: December 2022

Abstract
This article defends Marjorie Suchocki’s position against two main objections raised by David E. Conner. Conner objects that God as a single actual entity (affirmed by Suchocki) must be temporal because there is succession in God’s experience of the world. The reply is that time involves at least two successive occasions separated by perishing, but in God nothing ever perishes. Conner also objects that Suchocki’s personalistic process the-ism is not experiential but is instead theoretical (based on what Whitehead says in Part V of PR) and not definitive. The reply is that his dismissal of Part V of PR is arbitrary, the interpretation of all experience is theoretical, and no metaphysical interpretations are absolutely definitive, including PR as a whole. Also, Conner ignores religious experience.
The Pacifism of Duane Friesen: Engaged Realism, Process Thought, and Critical Assessment
Authors: Murphy Timothy 
Published: December 2022

Abstract
This paper reviews Duane Friesen’s version of pacifism, particularly his realist approach, his demand for political engagement, and his proactive peacemaking stance. Second, it demonstrates his connections with process thought, especially around notions of ordered novelty and contrasts, the nonviolence of God, and eschatological openness. It provides three areas of critique and suggests alternatives, specifically concerning Friesen’s Christology, his notion of revelation, and his commitment to religious pluralism. This paper offers a form of pacifism for radical mainline Christians who would otherwise be hesitant concerning some of Friesen’s theological presuppositions. The paper endeavors to show Friesen’s general compatibility with process philosophical commitments, thus furthering the conversation with process theologians who remain skeptical of pacifist commitments.
Quantum Collapse and the Emergence of Actuality from Potentiality
Authors: Stapp Henry P. 
Published: December 2022

Abstract
Orthodox quantum mechanics is built upon psychophysical collapse events that are the close anahgs, within contemporary physical theory, of the the Whiteheadian actual occasions, with their mental and physical poles. This article describes the way in which these events enter into quantum theory, and mediate the emergence of actuality from potentiality.