bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current and projected incidence trends of pediatric-onset inflammatory bowel disease in Germany based on the Saxon Pediatric IBD Registry 2000–2014 –a 15-year evaluation of trends
Authors: Kern Ivana , Schoffer Olaf , Richter Thomas , Kiess Wieland , Flemming Gunter , Winkler Ulf , Quietzsch Jürgen , Wenzel Olaf , Zurek Marlen , Manuwald Ulf , Hegewald Janice , Li Shi , Weidner Jens , de Laffolie Jan , Zimmer Klaus-Peter , Kugler Joachim , Laass Martin W. , Rothe Ulrike 
Published: September 2022

Aims
An increasing number of children and adolescents worldwide suffer from inflammatory bowel disease (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC). The present work aims to investigate the incidence, prevalence and future trends of IBD in children and adolescents in Saxony, Germany.

Methods
The Saxon Pediatric IBD Registry collected data on patients up to 15 years of age from all 31 pediatric hospitals and pediatric gastroenterologists in Saxony over a 15-year period (2000–2014). In 2019, an independent survey estimated a registry completeness of 95.7%. Age-standardized incidence rates (ASR) per 100,000 person-years (PY) and prevalence per 100,000 children and adolescents were calculated. Evaluation was also been performed in sex and age subgroups. Joinpoint and Poisson regression were used for trend analyses and projections.

Results
532 patients with confirmed IBD during 2000–2014 were included in the epidemiological evaluation. 63.5% (n = 338) patients had CD, 33.1% (n = 176) had UC and 3.4% (n = 18) had unclassified IBD (IBD-U). The 15-year IBD prevalence was 111.8 [95%-CI: 102.3–121.3] per 100,000. The incidence ASR of IBD per 100,000 PY over the whole observation period was 7.5 [6.9–8.1]. ASR for the subtypes were 4.8 [4.3–5.3] for CD, 2.5 [2.1–2.9] for UC and 0.3 [0.1–0.4] for IBD-U. The trend analysis of ASR using the joinpoint regression confirmed a significant increase for incidence of IBD as well as CD. For IBD, the ASR per 100,000 PY increased from 4.6 [2.8–6.3] in 2000 to 8.2 [7.5–13.6] in 2014; projected incidence rates for IBD in Germany are 12.9 [6.5–25.5] in the year 2025 and 14.9 [6.7–32.8] in 2030, respectively. Thus, the number of new IBD diagnoses in Germany would more than triple (325%) in 2030 compared to 2000. The increase is expected to be faster in CD than UC, and be more in males than in females. The expected number of newly diagnosed children with IBD in Germany is projected to rise to about 1,584 [1,512–1,655] in 2025, and to about 1,918 [1,807–2,29] in 2030.

Conclusion
The incidence of IBD in children and adolescents in Saxony increased at a similar rate as in other developed countries during the observation period. Given this trend, the health care system must provide adequate resources for the care of these young patients in the future.
Efficacy of non-surgical interventions for promoting improved functional outcomes following acute compartment syndrome: A systematic review
Authors: Janakiram Naveena B. , Motherwell Jessica M. , Goldman Stephen M. , Dearth Christopher L. 
Published: September 2022

Background
Acute compartment syndrome (ACS) is a devastating complication which develops following a traumatic extremity injury that results in increased pressure within osteofascial compartments, thereby leading to ischemia, muscle and nerve necrosis, and creates a life-threatening condition if left untreated. Fasciotomy is the only available standard surgical intervention for ACS. Following fasciotomy the affected extremity is plagued by prolonged impairments in function. As such, an unmet clinical need exists for adjunct, non-surgical therapies which can facilitate accelerated functional recovery following ACS. Thus, the purpose of this systematic review was to examine the state of the literature for non-surgical interventions that aim to improve muscle contractile functional recovery of the affected limb following ACS.

Methods
English language manuscripts which evaluated non-surgical interventions for ACS, namely those which evaluated the function of the affected extremity, were identified as per PRISMA protocols via searches within three databases from inception to February 2022. Qualitative narrative data synthesis was performed including: study characteristics, type of interventions, quality, and outcomes. Risk of bias (RoB) was assessed using the Systematic Review Centre for Laboratory Animal Experimentation’s (SYRCLE) RoB tool and reported level of evidence for each article.

Results
Upon review of all initially identified reports, 29 studies were found to be eligible and included. 23 distinct non-surgical interventions were found to facilitate improved muscle contractile function following ACS. Out of 29 studies, 15 studies which evaluated chemical and biological interventions, showed large effect sizes for muscle function improvement.

Conclusions
This systematic review demonstrated that the majority of identified non-surgical interventions facilitated an improvement in muscle contractile function following pathological conditions of ACS.
Parents’ awareness, knowledge, and experiences of play and its benefits in child development: A systematic review protocol
Authors: Dhas Brightlin Nithis , Chacko Shoba Mary , David Solomon Vince Soloman , Sriram Vimal 
Published: September 2022

Background
Play is an important childhood occupation and a medium for development. Parents’ attitudes towards play, knowledge about play and its benefits, and their experiences in facilitating effective play are key factors that determine the experiences of play in children. These factors related to parent’s understanding and experiences of play gain additional significance when the child has a disability. The aim of this systematic review is to synthesize the available evidence on awareness, knowledge, and experience of play among parents and to summarise the findings.

Method
MEDLINE, CINAHL, APA PsycINFO, Psychology Database, Sociological Abstracts, EMBASE, and Cochrane Collection Plus will be searched for studies of any design that investigate awareness, knowledge, and experience of play among parents and its benefits to child development. Manual searches from reference lists of relevant papers will also be completed. The primary outcomes are parents’ knowledge (what constitutes play), experiences (what parents feel about play) and awareness (benefits of play) about play. Three independent reviewers will screen identified papers with pre-defined eligibility criteria and extract data using a customized extraction form. Discrepancies will be resolved in discussion with a fourth reviewer. A synthesis of eligible studies and summary will be provided.

Discussion
A systematic review of quantitative and qualitative research evidence of parents’ awareness, knowledge, and experiences in play will be carried out. This will highlight parents’ own views on play among their children, current theories/domains related to parents’ awareness, knowledge, and experience in play, and outcome measures that have been used. In addition, comparison among views of parents of children with disabilities and parents of typically developing children will be made. The results will be presented as a summary of key findings under the themes of awareness, knowledge, and experience of parents in play.
Prevalence of people with sickle cell disease and leg ulcers in Brazil: Socioeconomic and clinical overview
Authors: Spira Josimare Aparecida Otoni , Borges Eline Lima , Guedes Antônio Carlos Martins , Andrade Paula Gabriela Ribeiro , Lima Vera Lúcia de Araújo Nogueira 
Published: September 2022

ObjectiveTo identify the prevalence of people with leg ulcers resulting from sickle cell disease, as well as to describe the clinical, social, economic, and demographic conditions of these people.MethodDescriptive study, carried out at the Minas Gerais Hematology and Hemotherapy Center Foundation. The study population consisted of individuals over the age of 18 with a diagnosis of sickle cell disease in the State of Minas Gerais, Brazil. Data collection was performed from August 2019 to April 2020 through interviews. For the prevalence calculation, a census was taken of 5,379 people over the age of 18 with sickle cell disease, 77 of whom had active leg ulcers. Descriptive data analysis was performed using SPSS software (version 20.0, Chicago, IL, USA).ResultsThe prevalence of people with leg ulcers in Minas Gerais, Brazil was 1.4%. Of the 72 respondents, the average age was 39 years (range 18–64 years), 41.7% were single, 48.6% said they were black, 84.7% lived in their own house, 38.9% were retired, 61.1% had an income of one minimum wage. The median years of education was 10.5, 50% cited the church as a place for leisure activities, 79.2% denied smoking. Regarding pain, the median score was 3, the median baseline hemoglobin was 7.7 g/dL, and 91.7% had the HbSS genotype. The median age of the first ulcer was 18 years, 77.8% of active ulcers were recurrent, and 59.7% had only one active ulcer. The median time of existence of the ulcer was 3 years. The ulcer prevented 80.6% of people from doing some activity. Prejudice was experienced by 48.6% of the participants.ConclusionThe estimated prevalence of leg ulcers was lower than what it reported in the literature, however, the recurrence and the duration of ulcers were high. These findings bring reflection about the assistance to people with leg ulcer.
Determinants of the health care service choices of long-term mechanical ventilation patients: Applying andersen’s behavioral model
Authors: Liang Hui-Yu , Lee Ming-Der , Lin Kuan-Chia , Lin Lieh-Hann , Yu Shu 
Published: September 2022

AimsThe number of ventilator-dependent patients is rapidly increasing globally. As a result, long-term mechanical ventilation (LTMV) patients face the choice of receiving health care in respiratory care wards (RCWs) rather than at home. In this study, we applied Andersen’s behavioral theoretical model (ABM) to investigate the determinants of the health care service decisions of patients receiving LTMV.MethodsA cross-sectional research design and cluster random sampling were used to select 365 participants from nine RCWs and eight home care facilities in northern Taiwan. Data were collected in face-to-face interviews using a structured questionnaire.ResultsOf the predisposing factors, advanced age and an education level of at least junior high school influenced the choice to use RCW services. Being married, living with extended family, and medium or higher socioeconomic status were associated with the decision to use home care services. Of the enabling factors, patients with more caregivers, those whose family caregivers held strong beliefs about providing care, and those who perceived greater social support from health care providers were more likely to choose home care services. Of the need factors examined, poor cognitive function and higher dependence on assistance for activities of daily living (ADL) increased the probability of patients choosing RCW services. Hierarchical logistic regression analysis indicated that our final model accounted for 44.8% of the observed variance in health care service choice.ConclusionsABM enables an improved understanding of the health care service choices of LTMV patients. Our findings also highlight the importance of rigorously assessing patient needs and helping patients choose the most appropriate health care service.
Understanding the role of e-cigarette use in smoking cessation based on the stages of change model
Authors: Yoon Wonjeong , Cho Inhyung , Cho Sung-il 
Published: September 2022

Objective
We explored the role of e-cigarette use in smoking cessation based on the stages of change (SOC) model, which is a framework for describing the process of smoking cessation.

Methods
We used nationwide, cross-sectional data on adults (19+ years) from the seventh Korea National Health and Nutrition Examination Survey (KNHANES, 2016–2018) and restricted the participants to 3,929 recent smokers, consisting of current smokers and recent quitters (≤2 years). A multinomial logistic regression analysis was performed to reveal the relationships between e-cigarette use and cigarette quitting behaviors (e.g., current quitting status, past quit attempts, intention to quit, and duration of quitting) and all stages in smoking cessation, with adjustment for sociodemographic and smoking-related factors.

Results
E-cigarette use was positively related to past quit attempts, while not having quit, intention to quit, and longer duration of quitting. Based on the cessation stages, current and former e-cigarette users were significantly more likely to be in the ‘Precontemplation’ and ‘Contemplation’ stages than never users, while not to be in the ‘Preparation’ and ‘Action’ stages. Current users were particularly less likely to be in the ‘Maintenance’ stage compared to never users.

Conclusion
E-cigarette use was closely linked with early-stage behavior than late-stage behavior in the smoking cessation process. E-cigarettes might promote quit attempts and short-term quitting in some smokers, but the negative role of inducing smokers to continue cigarette smoking with no immediate quit-intention for future attempts is dominant in the real world.
Functional gastrointestinal disorders and nutritional status in junior high school students
Authors: Alatas Fatima Safira , Salsabila Khansa , - Nadira , Amalia Nasya , Hanafi Gryselda 
Published: September 2022

Background The prevalence of functional gastrointestinal disorders (FGIDs) is increasing among students in Indonesia. More adolescents came to the clinic with symptoms of functional constipation (FC), irritable bowel syndrome (IBS), and functional dyspepsia (FD).
Objective To analyze the relationship between the nutritional status, dietary pattern, and physical activity with the incidence of the FGIDs among Indonesian junior high school students.
Methods A cross-sectional study, consisting of 292 students aged 11 to 14 years were recruited in March 2018. Questionnaires on the ROME Criteria for FGIDs, dietary patterns, and physical activity were distributed to the students’ parents and returned in 24 hours.
Results The overall prevalence of FGIDs in this study was 26.4%. Among 292 junior high school students, 19.5% were diagnosed with FC, 6.2% with IBS, and 17.5% with FD. Overnourishment (overweight or obese) was found in 51.4% of the subjects. A significant association was found between FC and overnutrition (OR 2.27; 95%CI 1.21 to 4.28; P=0.011). Nutritional status did not affect the incidence of IBS nor FD. Rarely eating breakfast significantly increase the occurrence of FD (OR 4.80; 95%CI 1.61 to 13.25; P=0.004). No significant association between dietary patterns and physical activity with the prevalence of the other FGIDs.
Conclusion Nutritional status does not significantly affect the prevalence of IBS and FD. Overnourishment is associated with increased occurrence of FC. Eating breakfast twice weekly or more may reduce the probability of FD. Lack of healthy dietary pattern and physical activity are not correlated with other FGIDs.
School Curriculum in the News: Black Lives Matter and the Continuing Struggle for Culturally Responsive Education
Authors: Feuerstein Abe 
Published: September 2022

This project examines similarities and differences in the ways that major U.S. newspapers (e.g., The New York Times, The Washington Post, etc.) and the more focused ethnic and minority press (e.g., The Baltimore Afro-American, The Milwaukee Courier, etc.) characterize educator’s efforts to adopt more culturally responsive educational practices and curriculum. The analysis utilized two distinct full-text ProQuest news databases, U.S. Major Dailies and Ethnic News Watch, and Boolean search logic to identify a corpus of 72 relevant articles. Within these articles, a process of close reading and coding identified three major frames that cut across articles drawn from both databases: Challenging the Dominant Narrative; Activism and Engaged Citizenship; and Defending American Heritage and Patriotism. Differences in the use of these frames across the two datasets are discussed. These frames are interpreted in light of conflicting views on the nature of the American dream.
Dana Kampanye Pemilu yang Mahal, Sebuah Konsekuensi Logis atas Berlangsungnya Demokrasi Hari Ini
Authors: Setiawan Heri 
Published: September 2022

"Hingar bingar foto penuh senyum dan nomor urut menghiasi seluruh penjuru jalanan utama hingga pelosok gang-gang kecil, dari yang berukuran sangat besar dan megah sampai yang kecil dan minimalis, dari yang didesain sempurna maupun yang alakadarnya. Tak ketinggalan pula, selogan dan janji manis melengkapi semarak peperangan mereka"Itulah sekiranya gambaran yang "menghantui" kita selama kurang lebih satu bulan masa kampanye Pemilu, baik itu pemilu legislatif ataupun pemilu Presiden dan Wakil Presiden. Pada dasarnya, semua atribut- atribut tersebut memerlukan pendanaan. Jumlah dana yang diperlukan bisa berkisar puluhan ribu hingga puluhan juta. Peraturan perundang-undangan tentu mengatur semua prihal pendanaan pemilu. KPU juga Giat bergerak dalam meminta laporan dana kampenye Pemilu. bagi partai politik ataupun peserta pemilu yang akan mengikuti proses pemilu dengan tujuan untuk transaransi kepada publik, tertib administrasi, dan sebagai bentuk pelaksanan peraturan perundang-undangan. Ketika memasuki masa tenang kampanye, Pemerintah Kota/ Kabupaten akan menertibkan semua tempat dari atribut-atribut tersebut, abaik yang berbentuk baliho, benner, MMT, backdrop, poster, maupun stiker. Saat itulah, semua atribut tersebut berubah menjadi tak lebih dari tumpukan "sampah"
Pers Mahasiswa dalam Benturan Neoliberalisme
Authors: Ash Shiddiq Ahmad Fahmi 
Published: September 2022

Neoliberalisme menjadi besar dan menemukan momentumnya di tengah derasnya arus globalisasi abad ke-21. Dengan semangat liberalisme klasik, tetapi tampilan yang lebih futuristik dan menarik, membuatnya mampu merasuk dalam segala aspek kehidupan, tak terkecuali media dan informasi. Pelaku pers (jurnalis) mendapat tantangan yang besar, bukan lagi soal kebebasan berpendapat dan keterbukaan informasi publik, tetapi tentang idealisme, semangat membela dan mewartakan kebenaran, juga tantangan dari pers era citizen journalism (jurnalisme warga). Begitu pula pers mahasiswa, jurnalis-jurnalis kampus menghadapi tantangan dari maraknya arus neoliberalisme. Dengan semangat anak muda (mahasiswa), Pers Mahasiswa sangat dinantikan kiprah dan goresan emasnya di tengah lesunya gerakan mahasiswa dan derasnya arus neoliberalisme di Indonesia yang juga merasukpada sistemPendidikan Tinggi.Idealisme dan independensi Pers Mahasiswa mendapat benturanhebat dari neoliberalisme.Kata Kunci: Pers Mahasiswa, Neoliberalisme, Idealisme.
Amnesti Pajak Dalam Prespektif Keadilan dan Pembangunan Nasional
Authors: Chrystofer Chrystofer 
Published: September 2022

Pembangunan nasional bertujuan untuk mewujudkan masyarakat yang adil dan makmur, serta membutuhkan modal yang sangat besar. Modal, baik dalam bentuk uang maupun bentuk lainnya yang mempunyai nilai ekonomis, mempunyai peranan penting minimal dalam 2 hal, yaitu sebagai investasi dalam upaya meningkatkan pertumbuhan ekonomi untuk menciptakan kemakmuran rakyat, kedua, pertumbuhan ekonomi akan meningkatkan penerimaan pajak. Meskipun pajak bukan satu-satunya faktor pendorong minat investasi, akan tetapi sistem perpajakan yang berlaku di suatu negara menjadi pertimbangan sendiri bagi investor untuk memilih negara mana yang akan dijadikan tempat investasi. Pengenaan pajak yang relatif kecil atau pembebasan pajak pada suatu negara (tax haven) menjadi menarik bagi investor karena sudah menjadi gejala masyarakat di negara manapun. Orang cenderung untuk membayar pajak relatif kecil, bahkan mengelak atau menghindari pajak. Tindakan yang demikian jelas akan merugikan penerimaan negara dari sektor pajak (Tax Loss). Perkembangan global mengenai amnesti pajak dan pembebasan utang pajak semakin banyak dilakukan di berbagai negara, kemudian pemerintah Indonesia terdorong dan memutuskan untuk mengeluarkan kebijakan mengenai Amnesti Pajak. Amnesti pajak adalah program pengampunan yang diberikan oleh Pemerintah kepada wajib pajak meliputi penghapusan pajak yang seharusnya terutang, penghapusan sanksi administrasi perpajakan, serta penghapusan sanksi pidana di bidang perpajakan atas harta yang diperoleh. Amnesti pajak dilakukan dalam rangka perkembangan ekonomi Indonesia dalam menghadapi tekanan ekonomi global, tekanan ekonomi eksternal,maupun masalah internal ekonomi dalam negeri. Pemberian amnesti pajak dalam aspek lain juga dirasakan merugikan Negara dan bertentangan dengan keadilan. Hal ini disebabkan karena tidak adanya penghargaan bagi wajib pajak yang taat membayar pajaknya. Namun,penunggak pajak yang tidak membayar pajaknya sejak lama diberi keringanan dengan dihapuskan sanksi administrasi terkait utang pajak yang belum dibayarkan.Kata Kunci: Pembangunan nasional, amnesti pajak, keadilan.
Heterozygous expression of Cre recombinase in podocytes has no impact on the anti‐glomerular basement membrane glomerulonephritis model in C57BL/6J mice
Authors: Mousseaux Cyril , Migeon Tiffany , Frère Perrine , Verpont Marie Christine , Lutete Elisabeth , Navarro Claire , Louedec Liliane , Hadchouel Juliette 
Published: September 2022

AbstractA recent article described a thickening of the glomerular basement membrane (GBM) along with changes in the expression of key components of the extracellular matrix in 6‐month‐old NPHS2‐Cre transgenic mice, which express the Cre recombinase specifically in podocytes. This transgenic line has been widely used to characterize the implication of candidate genes in glomerular diseases in younger mice. Using a different mouse strain (C57BL/6J) than the previous report (129S6/SvEvTac), we sought to characterize 3‐ and 6‐month‐old NPHS2‐Cre+/− mice in control and pathological conditions. At baseline, there was no difference in renal function and histology between control and NPHS2‐Cre+/− mice. Notably, GBM thickness evaluated by transmission electron microscopy was similar between the two groups. We then induced an immune‐mediated severe glomerular insult, the anti‐glomerular basement membrane glomerulonephritis model (anti‐GBM‐GN) in 3‐month‐old control and NPHS2‐Cre+/− mice. NPHS2‐Cre+/− mice exhibited the same alterations in renal function and structure as control mice. In summary, our study strongly suggests that NPHS2‐Cre+/− transgenic mice on a C57BL/6J background can be safely used for podocyte‐specific gene inactivation in control conditions and in the anti‐GBM‐GN model.
Posidonius’ Two Systems: Animals and Emotions in Middle Stoicism
Authors: Harriman Benjamin 
Published: September 2022

Abstract
This paper attempts to reconstruct the views of the Stoic Posidonius on the emotions, especially as presented by Galen’s On the Doctrines of Hippocrates and Plato. This is a well-studied area, and many views have been developed over the last few decades. It is also significant that the reliability of Galen’s account is openly at issue. Yet it is not clear that the interpretative possibilities have been fully demarcated. Here I develop Galen’s claim that Posidonius accepted a persistent, non-rational aspect of the soul that he connects with the merely animal part of humans. The aim is to begin from this testimony in answering two questions: (1) How might the possession of a non-rational element of the soul operate alongside the hêgemonikon (leading-part of the soul) as a source of impulse for Posidonius. (2) How does this persistent animal aspect conform to the Stoic ontological classification found in their scala naturae? I shall argue in response to these that (a) Posidonius distinguished the merely cognitive aspects of the soul from those that are rational, and (b) that the hêgemonikon itself is not to be identified with what is rational. Accepting a persistent non-rational source of emotional impulses allows Posidonius a richer framework for explaining human affective responses and behaviours. I also briefly address Galen’s motivation for the account he offers. It is in view of Posidonius’ approach to Plato’s Timaeus that Galen’s discussion finds its most plausible interpretation.