bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Effectiveness of Sustainability Measurement: Which ESG Metrics Will Survive COVID-19?
Authors: Atkins Jill , Doni Federica , Gasperini Andrea , Artuso Sonia , La Torre Ilaria , Sorrentino Lorena 
Published: August 2022

Abstract
This paper aims to investigate the current state of play on Environmental Social and Governance (ESG) integration and check the validity of the current metrics system by assessing if it will survive the COVID-19 crisis. By adopting a qualitative research approach through semi-structured anonymous interviews with 14 senior managers of six European listed companies we use a framework by assessing the mechanisms of reactivity on the effectiveness of ESG measures in times of COVID-19. By interpreting the practitioners’ points of view through the lens of the sociological framework by Espeland and Sauder (Am J Sociol 113:1–40, 2007) our findings show different mechanisms of reactivity by companies on the effectiveness of ESG measures in times of COVID-19, i.e., active and passive conformity and active resistance. We also identified the main Corporate Social Responsibility (CSR) institutional factors that affect managers’ reactivity. An extensive re-formulation of the ESG metrics is required in the light of times of crisis, given that accountability and transparency are strongly linked to quantitative measures which can play a critical role in the financial system and investors’ engagement. Particularly, the strict distinction between “E”, “S” and “G” issues should be abandoned claiming a different holistic re-design of sustainability measures by considering the increasing relevance of the Social dimension in time of COVID-19. This study provides a valuable contribution to the existing literature on the measurement of sustainability within the link of accountability and crisis by highlighting new corporate needs to re-design the ESG metrics system.
Plant abandonment behavior and fitness of monarch larvae (Danaus plexippus) is not influenced by an intraspecific competitor
Authors: Fisher Kelsey E. , Bradbury Steven P. 
Published: August 2022

AbstractIntegrating aspects of larval lepidopteran behavior that enhance survival into conservation plans could increase the overall impact of the efforts. We previously recommended that where possible, maintaining 2–4 ramets of closely-spaced common milkweed would support the development of at least one monarch through pupation, based on a seemingly innate behavior in which monarch larvae (Danaus plexippus) abandon their natal milkweed ramet (Asclepiassp.). Here, we explored the impact of intraspecific competition on larval ramet abandonment behavior and fitness of monarch larvae in small artificial milkweed patches.We observed larvae reared under direct and indirect intraspecific competition, and larvae reared alone.We found no influence of intraspecific competition; however, our study provides further support that milkweed ramet abandonment is a seemingly innate behavior. This behavior occurs before all of the available leaf biomass on a ramet is consumed and prior to the pre-pupal wandering stage.Implications for insect conservation: Results from our study suggest that in the absence of predation, parasitism, and interspecific competition, and when sufficient plant biomass is present to support larval development, the presence of an intraspecific competitor does not influence larval behavior or fitness. Based on milkweed ramet abandonment behavior, we continue to suggest maintaining small patches of 2–4 milkweed ramets when possible.
Developing A Conceptual Framework for Early Intervention Vocational Rehabilitation for People Following Spinal Cord Injury
Authors: Dunn Jennifer A. , Martin R. A. , Hackney J. J. , Nunnerley J. L. , Snell D. L. , Bourke J. A. , Young T. , Hall A. , Derrett S. 
Published: August 2022

Abstract
Purpose
Early intervention vocational rehabilitation (EIVR) can improve return to work (RTW) outcomes for people with spinal cord injury (SCI). However, mechanisms explaining how and why EIVR works are not well understood. This study aims to develop a conceptual framework describing key mechanisms of EIVR intervention effect following SCI.

Methods
We synthesised data from a realist literature review with data from interviews of people with SCI (n = 30), a survey of people with SCI who had received EIVR (n = 37), a focus group of EIVR providers and a focus group of community vocational providers. We first synthesised the literature review and interviews to develop an initial programme theory describing the contexts in which mechanisms are activated to produce EIVR outcomes. Then we used data from the survey and focus groups to further refine the EIVR programme theory. Finally, a conceptual framework was developed to support knowledge dissemination.

Results
By ensuring consistent messaging across the multi-disciplinary team, EIVR programmes establish and maintain hope that work is possible following injury. Conversations about work allow individuals to determine the priority of work following injury. These conversations can also improve self-efficacy by providing individualized support to envisage pathways toward RTW goals and maintain worker identity. The synthesised study findings highlight the contexts and resources required to trigger activation of these mechanisms.

Conclusions
EIVR key mechanisms of effect are not specific to SCI as a health condition, therefore enabling this framework to be applied to other populations who face similar impairments and return to work barriers.
α-Enolase inhibits apoptosis and promotes cell invasion and proliferation of skin cutaneous melanoma
Authors: Zhang Kun , Tian Ruoxi , Zhang Wancong , Li Yishuai , Zeng Ning , Liang Yan , Tang Shijie 
Published: August 2022

Abstract
Background
The glycolytic enzyme, α-Enolase (ENO1), catalyzes the production of phosphoenolpyruvate from 2-phosphoglycerate, thereby enhancing glycolysis and contributing to tumor progression. In the present study, we aimed to determine the role of ENO1 in skin cutaneous melanoma (SKCM) and the potential underlying mechanism.

Methods
The Sangerbox database was used to analyze the mRNA expression of ENO1 in SKCM. Western blotting was used to assess the levels of ENO1, c-Myc, β-catenin, MMP-9, PGAM1, and MMP-13 in SKCM-derived cell lines or tumor tissues from patients with SKCM. The pCMV-SPORT6-ENO1 and pET-28a-ENO1siRNA plasmids were used to overexpress and knockdown ENO1 in SKCM cells, respectively. To determine the function of ENO1 in the malignant behavior of SKCM cells, we performed a wound-healing assay, cell counting kit 8 assay, and transwell chamber analyses. The production of pyruvate and lactic acid in tumor cells was evaluated using their respective kits.

Results
Compared with non-tumor tissues, ENO1 was found to be overexpressed in SKCM tissues. In SKCM cells, ENO1 overexpression promoted invasion, migration, and proliferation of tumor cells; increased pyruvate and lactate production; and increased β-catenin, MMP-9, MMP-13, and c-Myc levels. The opposite effects were observed in SKCM cells silenced for ENO1.

Conclusions
These results indicate that ENO1 is involved in SKCM progression by enhancing the invasion and proliferation of tumor cells. In addition, ENO1 might have an important function in tumor cell glycolysis. Therefore, ENO1 represents a potential therapeutic target for treatment of SKCM.
The stability of 3-DOF triple-rigid-body pendulum system near resonances
Authors: Amer T. S. , El-Sabaa F. M. , Zakria S. K. , Galal A. A. 
Published: August 2022

AbstractIn this article, the motion of three degree-of-freedom (DOF) dynamical system consisting of a triple rigid body pendulum (TRBP) in the presence of three harmonically external moments is studied. In view of the generalized coordinates of the system, Lagrange's equations are used to obtain the governing system of equations of motion (EOM). The analytic approximate solutions are gained up to the third approximation utilizing the approach of multiple scales (AMS) as novel solutions. The solvability conditions are determined in accordance with the elimination of secular terms. Therefore, the arising various resonances cases have been categorized and the equations of modulation have been achieved. The temporal histories of the obtained approximate solutions, as well as the resonance curves, are visually displayed to reveal the positive effects of the various parameters on the dynamical motion. The numerical results of the governing system are achieved using the fourth-order Runge–Kutta method. The visually depicted comparison of asymptotic and numerical solutions demonstrates high accuracy of the employed perturbation approach. The criteria of Routh–Hurwitz are used to investigate the stability and instability zones, which are then analyzed in terms of steady-state solutions. The strength of this work stems from its uses in engineering vibrational control applications which carry the investigated system a huge amount of importance.
Transcriptional Feedback in Plant Growth and Defense by PIFs, BZR1, HY5, and MYC Transcription Factors
Authors: Koene Selena , Shapulatov Umidjon , van Dijk Aalt D. J. , van der Krol Alexander R. 
Published: August 2022

AbstractGrowth of Arabidopsis is controlled by the activity of a set of bHLH and bZIP transcription factors of which phytochrome interacting factor4 (PIF4), BRASSINAZOLE-RESISTANT 1 (BZR1), and elongated hypocotyl 5 (HY5) have been most extensively studied. Defense responses are controlled by a set of MYC transcription factors of which MYC2 is best characterized. Moreover, hundreds of additional proteins (here named co-factors) have been identified which (in)directly may affect the expression or activity of these TFs. Thus, regulation of expression of genes encoding these co-factors becomes an integral part of understanding the molecular control of growth and defense. Here, we review RNA-seq data related to PIF, BZR1, HY5, or MYC activity, which indicate that 125 co-factor genes affecting PIFs, HY5, BZR1, or MYCs are themselves under transcriptional control by these TFs, thus revealing potential feedback regulation in growth and defense. The transcriptional feedback on co-factor genes related to PIF4, BZR1, and MYC2 by PIFs, BZR1, or MYCs, mostly results in negative feedback on PIF4, BZR1, or MYC2 activity. In contrast, transcription feedback on co-factor genes for HY5 by HY5 mostly results in positive feedback on HY5 activity. PIF4 and BZR1 exert a balanced regulating of photoreceptor-gene expression, whose products directly or indirectly affect PIF4, HY5, and MYC2 protein stability as a function of light. Growth itself is balanced by both multiple positive and multiple negative feedback on PIF4 and BZR1 activity. The balance between growth and defense is mostly through direct cross-regulation between HY5 and MYC2 as previously described, but also through potential transcriptional feedback on co-factor genes for MYC2 by PIF4, BZR1, and HY5 and through transcriptional feedback of co-factors for PIF4 and BZR1 by MYC2. The interlocking feed-forward and feed-backward transcriptional regulation of PIF4, BZR1, HY5, and MYC2 co-factors is a signature of robust and temporal control of signaling related to growth and defense.
Coming of Age: Renovation Premiums in Housing Markets
Authors: Mamre Mari O. , Sommervoll Dag Einar 
Published: August 2022

Abstract
We rely on novel textual analysis of real estate listings and identify renovated dwellings in a dataset of Norwegian transactions to estimate the renovation premium in an urban housing market. The renovation premium is estimated in a hedonic framework by classical regression approaches and a random forest algorithm. The strength of the latter is that it allows for a more complex interplay between the renovation premium and explanatory variables. We estimate a significant positive renovation premium of 5–7 percent for renovated dwellings and a negative premium of 9–10 percent for unmaintained/neglected dwellings. These averages mask significant variations in these premiums over time, particularly, a counter-cyclical effect. Omitting renovation information also has implications for estimated short-term house price growth. Unmaintained dwellings tend to transact more in the fourth quarter, indicating that parts of the seasonal price variation reported in the literature are due to compositional variation with respect to renovation. This composition effect bias price movement estimates downward, if uncontrolled for, as unmaintained dwellings transact at significantly lower prices.
Broadband Damping Properties of Particle Dampers Mounted to Dynamic Structures
Authors: Schönle A. , Gnanasambandham C. , Eberhard P. 
Published: August 2022

AbstractBackgroundThe background of this work is the classification of the broadband properties of particle dampers (PDs). This broadband characteristic has experienced little systematic investigation in experiments.ObjectiveSo the primary objective of this paper is to find a measure to quantify the broadband damping properties of PDs. Also the demonstration of applicability to technical structures is a desired goal and the experiments provide a sound basis.MethodsThe methods for evaluating the performance of particle dampers and tuned mass dampers target the reduction of vibration amplitudes over the frequency range. The test bench consists of a mechanical frame structure with multiple eigenfreqencies up to 200 Hz harmonically excited with an electrodynamic shaker. From the differences in the dynamic behaviour the performance metric will be derived and evaluated.ResultsAs a result, a dynamic structure is set up as an effective test bench for different damper configurations. Differences of the tested concepts in regard to the dynamic behaviour over a wide frequency range are observed. From the experimental data a performance metric is deduced to quantify these differences.ConclusionThe conclusions drawn from this paper are, that PDs provide high damping over a wide frequency range. Furthermore, with a suitable performance metric this broadband damping properties can be quantified for the use in further development of PDs.
Experimental Measurement of Infinite Dilution Thermal Neutron Self-shielding Factor
Authors: Mahmoud Ateia W. , Elmaghraby Elsayed K. , Salama E. , Elghazaly A. , El-fiki S. A. 
Published: August 2022

AbstractThe absorption of neutrons in media together with its transport properties cause the neutron flux to decrease as it penetrates the material because the absorption of neutrons in the sample itself attenuates the neutrons flux as it goes deeper into the sample. In the present work, the thermal neutron self-shielding factors of indium, gold, zinc, and mercury were determined experimentally. The current results together with those found in the literature were used to validate a mathematical ab initio formulae based on integral cross-section parameters used to compare our results. The complete agreement among these species of data suggests the validity of correlating the neutron migration length in the convex-shaped material with the average chord length described in the mathematical model.
Asymptotics of the s-fractional Gaussian perimeter as $$s\rightarrow 0^+$$
Authors: Carbotti Alessandro , Cito Simone , La Manna Domenico Angelo , Pallara Diego 
Published: August 2022

AbstractWe study the asymptotic behaviour of the renormaliseds-fractional Gaussian perimeter of a setEinside a domain$$\Omega $$Ωas$$s\rightarrow 0^+$$s→0+. Contrary to the Euclidean case, as the Gaussian measure is finite, the shape of the set at infinity does not matter, but, surprisingly, the limit set function is never additive.
Enhancing Examination Success: the Cumulative Benefits of Self-Assessment Questions and Virtual Patient Cases
Authors: Seagrave Martha P. , Foster-Johnson Lynn , Waits John B. , Margo Katherine , Leong Shou Ling 
Published: August 2022

Abstract

Purpose
Research on the learning benefits of the feedback-rich formative assessment environment of virtual patient cases (VPCs) has largely been limited to single institutions and focused on discrete clinical skills or topical knowledge. To augment current understanding, we designed a multi-institutional study to explore the distinct and cumulative effects of VPC formative assessments and optional self-assessment questions (SAQs) on exam performance.

Method
In this correlational study, we examined the records of 1,692 students on their family medicine (FM) clerkship at 20 medical schools during the 2014–2015 academic year. Schools utilized an established online curriculum, which included family medicine VPCs, embedded formative assessments, context-rich SAQs corresponding with each VPC, and an associated comprehensive family medicine exam. We used mixed-effects modeling to relate the student VPC composite formative assessment score, SAQ completion, and SAQ performance to students’ scores on the FM final examination.

Results
Students scored higher on the final exam when they performed better on the VPC formative assessments, completed associated SAQs, and scored higher on those SAQs. Students’ SAQ completion enhanced examination performance above that explained by engagement with the VPC formative assessments alone.

Conclusions
This large-scale, multi-institutional study furthers the body of research on the effect of formative assessments associated with VPCs on exam performance and demonstrates the added benefit of optional associated SAQs. Findings highlight opportunities for future work on the broader impact of formative assessments for learning, exploring the benefits of integrating VPCs and SAQs, and documenting effects on clinical performance and summative exam scores.
Multi-granularity scenarios understanding network for trajectory prediction
Authors: Yang Biao , Yang Jicheng , Ni Rongrong , Yang Changchun , Liu Xiaofeng 
Published: August 2022

AbstractUnderstanding agents’ motion behaviors under complex scenes is crucial for intelligent autonomous moving systems (like delivery robots and self-driving cars). It is challenging duo to the inherent uncertain of future trajectories and the large variation in the scene layout. However, most recent approaches ignored or underutilized the scenario information. In this work, a Multi-Granularity Scenarios Understanding framework, MGSU, is proposed to explore the scene layout from different granularity. MGSU can be divided into three modules: (1) A coarse-grained fusion module uses the cross-attention to fuse the observed trajectory with the semantic information of the scene. (2) The inverse reinforcement learning module generates optimal path strategy through grid-based policy sampling and outputs multiple scene paths. (3) The fine-grained fusion module integrates the observed trajectory with the scene paths to generate multiple future trajectories. To fully explore the scene information and improve the efficiency, we present a novel scene-fusion Transformer, whose encoder is used to extract scene features and the decoder is used to fuse scene and trajectory features to generate future trajectories. Compared with the current state-of-the-art methods, our method decreases the ADE errors by 4.3% and 3.3% by gradually integrating different granularity of scene information on SDD and NuScenes, respectively. The visualized trajectories demonstrate that our method can accurately predict future trajectories after fusing scene information.
Energy evolution and water immersion-induced weakening in sandstone roof of coal mines
Authors: Liu Wenjie , Yang Ke , Zhang Shuai , Zhang Zhainan , Xu Rijie 
Published: August 2022

AbstractThe instability of underground spaces in abandoned coal mines with water-immersed rocks is one of the main hazards hindering the geothermal energy use and ecological restoration of post-mining areas. This study conducted graded cyclic loading–unloading tests of five groups of sandstone samples with different water contents. The evolution of input, elastic, dissipated, damping, and plastic energies were explored, considering the damping effect. The normalized plastic energy serves to characterize the damage evolution of sandstone samples, whose failure characteristics were analyzed from both the macroscopic and microscopic perspectives. X-ray diffraction technique and scanning electron microscopy were used to reveal the softening mechanism of sandstone. The results show that under graded cyclic loading, input energy, elastic energy, and dissipated energy all increase gradually, and the fraction of elastic energy increases gradually at first and then tends to stabilize. The variation in the fraction of dissipated energy is opposite to that of elastic energy. In each cycle, the input energy is stored primarily in the form of elastic energy, whereas the dissipated energy is used primarily to overcome the damping of sandstone. When the normalized number of cycles approached unity, the plastic energy fraction sharply increases, while that of the dampening energy drops abruptly. With increasing water content, the effect of pore water on the lubrication, the water wedge, and dissolution of mineral particles becomes more obvious, reducing the elastic-storage limit of sandstone, meanwhile the sandstone damage factor increases significantly under the same cycle and the failure mode changes from brittle to ductile.
Turnip mosaic virus manipulates DRM2 expression to regulate host CHH and CHG methylation for robust infection
Authors: Wu Xiaoyun , Chai Mengzhu , Liu Jiahui , Jiang Xue , Yang Yingshuai , Guo Yushuang , Li Yong , Cheng Xiaofei 
Published: August 2022

AbstractDNA methylation is an important epigenetic marker for the suppression of transposable elements (TEs) and the regulation of plant immunity. However, little is known how RNA viruses counter defense such antiviral machinery. In this study, the change of DNA methylation in turnip mosaic virus (TuMV)-infected cells was analyzed by whole genome bisulfite sequencing. Results showed that the total number of methylated sites of CHH and CHG increased in TuMV-infected cells, the majority of differentially methylated regions (DMRs) in the CHH and CHG contexts were associated with hypermethylation. Gene expression analysis showed that the expression of two methylases (DRM2 and CMT3) and three demethylases (ROS3, DML2, DML3) was significantly increased and decreased in TuMV-infected cells, respectively. Pathogenicity tests showed that the enhanced resistance to TuMV of the loss-of-function mutant of DRM2 is associated with unregulated expression of several defense-related genes. Finally, we found TuMV-encoded NIb, the viral RNA-dependent RNA polymerase, was able to induce the expression of DRM2. In conclusion, this study discovered that TuMV can modulate host DNA methylation by regulating the expression of DRM2 to promote virus infection.