bluuebunny/crossref_metadata_2025_split huggingface dataset:
SD-KMSMOTE: oversampling method for imbalanced data based on spatial distribution of minority samples
Authors: Yang Wensheng , Pan Chengsheng , Zhang Yanyan 
Published: March 2022

Abstract
With the rapid expansion of data, the problem of data imbalance has become increasingly prominent in the fields of medical treatment, finance, network, etc. And it is typically solved using the oversampling method. However, most existing oversampling methods randomly sample or sample only for a particular area, which affects the classification results. To solve the above limitations, this study proposes an imbalanced data oversampling method, SD-KMSMOTE, based on the spatial distribution of minority samples. A filter noise pre-treatment is added, the category information of the near-neighbouring samples is considered, and the existing minority class sample noise is removed. These conditions lead to the design of a new sample synthesis method, and the rules for calculating the weight values are constructed on this basis. The spatial distribution of minority class samples is considered comprehensively; they are clustered, and the sub-clusters that contain useful information are assigned larger weight values and more synthetic sample numbers. The experimental results show that the experimental results outperforms existing methods in terms of precision, recall, F1 score, G-mean, and area under the curve values when the proposed method is used to expand the imbalanced dataset in the field of medicine and other fields.
Runoff Forecasting Based on Combining Multiple Neural Networks and Modal Decomposition
Authors: Jin Haoyu , Chen Xiaohong , Zhong Ruida , Liu Moyang , Pan Yingjie , Zhao Tongtiegang , Liu Zhiyong , Tu Xinjun 
Published: March 2022

Abstract
The runoff sequence has the characteristics of non-linear and non-steady state, which leads to the low accuracy of direct prediction. In order to extract the implicit information in the original data more effectively, the complex runoff sequence is decomposed into multiple components by using singular spectrum analysis (SSA) and wavelet packet decomposition (WPD) decomposition methods. The auto-correlation function (ACF) and partial auto-correlation function (PACF) methods are used to select the previous runoff order that has a significant impact on the current runoff. Then six kinds of neural network models are selected as simulation methods. The daily runoff and monthly runoff of the Baihe (BH) and Huangjiagang (HJG) stations in the Hanjiang River Basin (HRB) were taken as the research object. The research shows that the kurtosis value of each component obtained by the SSA decomposition method has a certain randomness, while the kurtosis value of each component of WPD gradually decreases, but the amount of information carried by the first component is too large. Although the monthly runoff changes are more regular, due to the large amount of daily runoff data used for training, the model runoff simulation effect is better than that of monthly runoff. Most models have the problem that the simulated runoff is too large when the runoff is small, and the simulation results are too small when the runoff is large. The main decision of the model results is the structure of the model itself, and the two decomposition methods have little effect on the prediction effect of the models. This study can provide a way to select a forecasting method for nonlinear and non-steady-state runoff time series forecasting.
Contact model of bolted joint under tangential load
Authors: Wang Shengao , Zhu Min , Cao Hongjun , Xu Zijian , Wen Binping , Hao Shibiao 
Published: March 2022

Abstract
This paper proposed a new contact model that describes the contact state and pressure distribution change in tangential stiffness softening. First, the accuracy of three modeling methods is evaluated. Then, on the basis of the smooth model, the contact state is studied, and an elliptical boundary model is proposed. Thirdly, the influence of the main parameters, preload and friction coefficient, on stiffness degradation is studied. Finally, the contact pressure distribution model under tangential load is proposed. The research content can be better applied to the stiffness degradation modeling of bolted structures.
Anticancer Potential of Hesperidin against HEp-2 Laryngeal Carcinoma Cell Line in Comparison to Doxorubicin
Authors: Wahed Sara Abd El , Hassabou Nadia Fathy , Hamouda Mai Abdelhalim 
Published: March 2022

Abstract
Background
Doxorubicin (DOX) is widely used in therapy of many carcinoma types. Unfortunately, it is not sufficiently effective in many cases and increasing the dosage of it is limited due to systemic toxicity. An important strategy to minimize the toxic effects of the above cited drug is to use co-adjuvant. A citrus flavonoid hesperidin (Hesp) has emerged as promising anticancer natural product and proved to be potent antioxidant agent. It inhibits cancer cell proliferation by inducing apoptosis and cell cycle arrest. In this context, the objective of this study was to investigate anticarcinogenic effects of Hesp in comparison with DOX against HEp-2 laryngeal carcinoma cell line.
Methods
Five groups of HEp-2 cell line were included, two groups were subjected to Hesp and the other two groups were subjected to DOX, which was used as a reference drug, in addition to a control untreated group. Expression of Bcl-2 and p53 genes was evaluated. Also, the cell cycle arrest and apoptotic effects were assessed.
Results
Hesp exerted anti-proliferative effects against HEp-2 cells which increase in time dependent manner. Gene profile analysis revealed highly significant decrease of anti-apoptotic Bcl-2 and highly significant increase of tumour suppressor gene P53 (p ˂ 0.01 and p ˂ 0.0001, respectively) for both tested drugs.
Conclusion
Hesp proved potential anticancer effects with reducing cancer cell viability in HEp-2 cell line via cell cycle arrest and apoptotic mechanism. It could be used as a pro-drug or co-adjuvant in treatment of oral cancer.
The publication pressure profiles among Chinese nurses: a latent profile analysis
Authors: Ju Dan-Dan , Xi Xin-Xue , Zeng Tie-Ying , Chen Ye , Zhang Ke 
Published: March 2022

Abstract
Background: Previous studies rarely addressed the issue of high publication pressure among nurses and the effects of such phenomenon on nursing research development. The present study aimed o identify the profiles of publication pressure among nurses and explore the protective factors for nurses' publication pressure.Methods: A cross-sectional study was conducted involving 924 nurses from a tertiary hospital in China. Latent profile analysis was adopted to identify publication pressure profiles among nurses. Multinomial regression was conducted to detect the identified characteristics' effect on publication pressure profiles.Results: Consistent with the Job Demands-resources Model, four profiles were divided. Profile III had the highest publication rate and a high job and life satisfaction level. The heaviest publication pressure (Profile I) was associated with a high professional title, protected by solid research capacity, adequate organizational support, and emphasis on nursing research.Conclusions: Nurses exhibit distinct profiles of publication pressure that reflect the imbalance between demands and resources among profiles. Current analyses suggest that Profile I nurses are particularly inneed of interventions addressing the heaviest publication pressure. Profile III nurses are adapted to the development of nursing research. The findings highlight that nursing managers could cultivate Profile III's nursing talents and formulate the targeted intervention for Profile I, II, and IV.
CEAC, BEAM and IEAC high-dose chemotherapy followed by autologous stem cell transplantation in peripheral T-cell lymphoma patients: A single center comparative analysis of efficacy and safety
Authors: Yi-Ying Xiong , Jing Wang , Li Wang , Jian-Bin Chen , Lin Liu , Xiao-Qiong Tang , Xin Wang , Hong-Bin Zhang 
Published: March 2022

Abstract
Autologous stem cell transplantation (ASCT) is an important treatment for Peripheral T-cell lymphoma (PTCL) patients both during front and salvage therapy. We retrospectively compared the outcomes of 52 PTCL patients treated with CEAC (n=28), BEAM (n=14) and IEAC (n=10) regimens followed by ASCT at our center between 2012 and 2021. Although the time of neutrophil engraftment in CEAC group was earlier than that in IEAC group (P=0.042) and platelet infusion in BEAM group was significantly more than CEAC group (P=0.042), there were no significant difference in platelet engraftment, hematopoietic engraftment and red blood cells infusion among the 3 groups. The transplantation related mortality rate (TRM) and the early overall response rate (ORR) was 3.8% and 85.7% respectively. The 5-year OS and PFS was 62.8% (95% CI: 54.8%-70.8%) and 61.0% (95% CI: 53.1%-68.9%) respectively. There was no significant difference in TRM, ORR and survival among the 3 groups. Univariate and multivariate analysis showed that high PIT score (＞1) and non-CR at 3 months after ASCT were common risk factors for OS (P=0.036 and 0.007) and PFS (P=0.021 and 0.012). In conclusion, CEAC and IEAC regimen can be used as alternative conditioning regiments for ASCT in PTCL patients, and their efficacy and safety are comparable to BEAM regiment. Patients with high PIT score and failure to reach CR early after ASCT had worse outcomes.
Expression and functional analyses of transformer-2 in Phytoseiulus persimilis and other genes potentially participating in reproductive regulation
Authors: Xuenong Xu , Qi Cai , Fan Yang , Zhenhui Wang , Bo Zhang , Endong Wang , Jiale Lv 
Published: March 2022

Abstract
Transformer-2 is an important sex-determining gene in insects and also plays roles in reproduction of Phytoseiid mites. We performed bioinformatics analyses for the transformer-2 ortholog in Phytoseiulus persimilis, measured its expression in different stages, and quantitatively identified its function in reproduction. This gene, termed as Pptra-2, encodes 288 amino acids with a conserved RRM domain. Its peak expression was observed in female adults, especially ca. 5 days after mating. Besides, expression in eggs is higher than that in other stages and male adults. When Pptra-2 was interfered through oral delivery of dsRNA, 56% females had their egg hatching rates decreased in the first 5 days, from ca. 100% to ca. 20%, and maintained at low levels during the rest of its oviposition period. To detect other genes functionally related to Pptra-2, transcriptome analyses were performed on the 5th day after mating. We compared mRNA expressions among interfered females with significant egg hatching rate decrease, interfered females with no significant egg hatching rate decrease, and the CK. A total of 403 differential genes were identified, among which 42 functional genes regulating female reproduction and embryonic development were screened and discussed.
Retinal Findings and Pitfalls of Optical Coherence Tomography Evaluation of The Inner Retina in Covid-19 Patients
Authors: de Sousa Ednan Cardoso , Oliveira Marília Maruza M Barros , Freitas Luiz Guilherme Azevedo , Lira Rodrigo Pessoa Cavalcanti , Barbosa Francisco Cordeiro , Gonçalves Fabiana Fonte , Freitas Theophilo , Freitas-Neto Clovis Arcoverde 
Published: March 2022

Abstract
Background: COVID-19 can cause retinal manifestations however, there are still gaps in the scientific literature about the repercussions of the disease on the retina, as well as concerns about the interpretation of the background and optical coherence tomography.Objective: To describe fundus findings in post-COVID-19 infection patients and evaluate the hyper-reflective images in the retinal ganglion cell layer (RGCL), with optical coherence tomography angiography (OCTA), to avoid imaging interpretation pitfalls.Methods: Cross-sectional study with analysis of thirty-eight eyes of nineteen confirmed COVID-19 infected patients was perfomed. The color fundus photography, optical coherence tomography (OCT), and OCTA were used. COVID-19 positive patients were included in the study and they were treated at a Brazilian referral hospital in July 2020. The study was approved by the Human Research and Ethics Committee.Results: The fundus abnormalities observed were the superficial hemorrhages 4/19 (21%) and cotton wool spots 1/19 (5,2%). We noticed hyper-reflective images on the ganglion cell layer corresponding to the physiologic macular vascular network vessels in all eyes. Follow-up scans examinations revealed pitfalls with the disappearance of some of the hyper-reflective images. Conclusion: Retinal superficial hemorrhage and cotton wool spots are unspecific findings usual to COVID-19 and others virus infections. Evaluating these findings with a multimodal imaging technique is recommended to avoid pitfalls and misinterpretation of hyper-reflective intraretinal images in OCT scans.
Surface electromyography study on asymmetry in paravertebral muscle degeneration in patients with degenerative lumbar scoliosis
Authors: Xie Hongru , Liu Jianan , He Yinchuan , Zhang Zepei , Dong Hongtao , Meng Lin , Miao Jun 
Published: March 2022

Abstract
Background: The asymmetry of paravertebral muscle (PVM) degeneration in degenerative lumbar scoliosis (DLS) patients has been extensively studied by imaging and histological examination and has not yet been verified by surface electromyography (sEMG) techniques.Objective:To study the relationship between the surface electromyography (sEMG) and degenerative characteristics of paravertebral muscles (PVMs) in patients with degenerative lumbar scoliosis (DLS).Method:In twenty DLS patients and fifteen healthy subjects, sEMG activity of the PVMs at the level of the upper end vertebra (UEV), apical vertebra (AV) and lower end vertebra (LEV) was measured during static standing and dynamic standing forward flexion and backward extension tasks. Action segmentation was achieved according to inertial measurement unit (IMU) data.The sEMG characteristics of the PVMs on the convex and concave sides were compared, and the relationship of these data with the Cobb angle and lumbar lordotic angle (LL) was analyzed.Results:In the DLS group, there was no difference in sEMG activity between the convex and concave sides at the UEV or AV level， but in the motion and return phases of the standing forward flexion task (P=0.000, P=0.015) and the maintenance and return phases of the standing backward extension task (P=0.001, P=0.01), there was a significant difference in sEMG activity between the convex and concave sides at the LEV level.Asymmetrical sEMG activity at the LEV level was negatively correlated with the Cobb angle (F=93.791，P <0.001) and LL angle (F=65.564，P <0.001).Conclusion:In the DLS group, asymmetrical sEMG activity of the PVMs appeared at the LEV level, with the concave side being more active than the convex side. This sEMG characteristics were consistent with their imaging and histological degenerative features and correlated with bone structural parameters.
Polyolefin depolymerization over silica-alumina-based catalysts: mechanistic classifications and benchmarking
Authors: Dyson Paul , Lee Wei-Tse , Muyden Antoine van , Bobbink Felix , Mensi Mounir , Carullo Jed 
Published: March 2022

Abstract
C-C bond cleavage mechanisms play a key role in the selective deconstruction of alkanes and polyolefins. The product distributions, i.e., formation of smaller hydrocarbons, unsaturated and isomerization products, serve as distinctive features that help to identify reaction pathways. Herein, Co, Ni or Ru nanoparticles immobilized on amorphous silica-alumina, Zeo-Y and ZSM-5, were evaluated as catalysts in the deconstruction of n-hexadecane (used as a model substrate for benchmarking purposes) with hydrogen to delineate the different mechanisms, i.e. monofunctional- (acid site dominated) or bifunctional-hydrocracking (acid site & metal site) versus hydrogenolysis (metal site dominated). The ZSM-5_H-based catalysts were further studied in the depolymerization of polyethylene. Based on these studies, the catalysts were plotted on an activity-mechanism map that functions as an expandable basis to benchmark catalytic activity and to identify the optimal depolymerization catalyst to afford specific products.
The perioperative outcomes of uniport versus two-port and three-port video-assisted thoracoscopic surgery in non-small cell lung cancer: a systematic review and meta-analysis
Authors: Cheng Ya-Fu , Huang Chang-Lun , Hung Wei-Heng , Cheng Ching-Yuan , Wang Bing-Yen 
Published: March 2022

Abstract
Background:Uniport video-assisted thoracoscopic surgery (VATS) has been applied widely for the treatment of lung cancer in recent years. Some studies have reported that uniport VATS might provide better outcomes than multiport VATS. However, the perioperative outcomes of uniport VATS compared with two-port and three-port VATS, respectively, have yet to be studied at a comprehensive scale. This meta-analysis study compares the perioperative efficacy among uniport, two-port, and three-port VATS.Methods:We searched studies published before October 1, 2019, by using Web of Science databases, Ovid Medline, Embase, and PubMed. Studies that compared uniport VATS with two-port or three-port VATS for patients with lung cancer were included. Operative time, perioperative blood loss, number of lymph nodes retrieved, conversion rate, duration of postoperative chest tube drainage, length of hospital stay (LoS), visual analogue pain scores on postoperative day (POD) 1 and POD 3, and overall morbidity were evaluated.Results: Sixteen studies that compared uniport VATS with two-port or three-port VATS in the treatment of lung cancer were included. Uniport VATS showed less blood loss, a shorter duration of postoperative drainage and a lower visual analogue pain score on POD 3 than two-port VATS; it showed a shorter duration of postoperative drainage, a shorter LoS, and lower visual analogue pain scores on POD 1 and POD 3 than three-port VATS. There were no significant differences in the number of lymph nodes retrieved, operative time, conversion rate, and overall morbidity rate when comparing uniport VATS with two-port VATS or three-port VATS.Conclusions: Uniport VATS might provide better perioperative outcomes than either two-port or three-port VATS in lung cancer treatment.
LncRNA ENSMUST_147219 mediated the progression of ischemic AKI via targeting of miR-221- 5p/IRF6 axis
Authors: Liu Jing , Li Xiaozhou , Yang Jurong , Zhang Dongshan 
Published: March 2022

Abstract
Although more studies revealed long noncoding RNAs (lncRNAs) regulated the progression of ischemic acute kidney injury(AKI), the exact role and mechanism of LncRNA ENSMUST_147219 in ischemic AKI was not unclear. In current study, LncRNA ENSMUST_147219 was induced by ischemic injury in vitro and vivo. Functionaly, LncRNA ENSMUST_147219 mediated the apoptosis in mouse proximal tubule-derived cell line(BUMPT) cells. Mechanistically, LncRNA ENSMUST_147219 sponged the microRNA (miR)-221-5p to upregulate the expression of Interferon Regulatory Factor 6 (IRF6) to drive apoptosis. Finally, knockdown of LncRNA ENSMUST_147219 markedly attenuated the ischemic AKI via targeting the miR-221-5p/IRF6 axis. Collectively, our data for the first time demonstrated that LncRNA ENSMUST_147219 promoted the development of ischemic AKI via regulation of miR-221-5p/IRF6 pathway, which could be considered as a new therapy target for ischemic AKI.
A Kubernetes ‘Bridge’ operator between cloud and external resources.
Authors: Lublinsky Boris , Jennings Elise , Spišaková Viktória 
Published: March 2022

Abstract
Many scientific workflows require dedicated compute resources, including HPC clusters with optimized software, quantum resources, and dedicated hardware cluster systems like Ray, for example. At the same time, many scientific workflows today are built on Kubernetes leveraging growing support for workflow and support tools. To address the growing demand to support workflows on both cloud and dedicated compute resources we present the Bridge Operator, a software extension for container orchestration in Kubernetes which facilitates the submission and monitoring of long running processes on external systems which have their own cluster resources manager (SLURM, LSF, quantum services and Ray). The Bridge Operator consists of a custom Kubernetes controller that employs a Kubernetes Custom Resource Definition to manage applications. We present controller logic to manage the cloud container orchestration and external resource workload manager interface, a resource definition to submit HTTP/HTTPS requests to the external resource, and a controller pod communicating with the external resource manager to submit and manage job execution. The implementation allows us to mirror the external resource in Kubernetes pods, which allows the operator to use these pods as proxies to control the external system. The implementation is agnostic to the choice of resource manager but assumes the system exposes a HTTP/HTTPS API for its control/management. The Bridge Operator automates the role of a human operator running jobs on a black box external resource as part of a complex hybrid workflow on the Cloud.
Quantitative assessment of the microstructure of the mesorectum with different prognostic statuses by intravoxel incoherent motion diffusion-weighed magnetic resonance imaging
Authors: Lu Bao-Lan , Chen Yan , Wen Zi-Qiang , Liu Yi-Yan , Ma Yu-Ru , Que Yu-Tao , Zhang Zhi-Wen , Wu Xue-Han , Yu Shen-Ping 
Published: March 2022

Abstract
PurposeThe mesorectum surrounding the rectal provides an ideal substrate for tumour spread. However, preoperative risk assessment is still an issue. This study aimed to investigate the microstructural features of mesorectum with different prognostic statuses by intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI).MethodsPatients with pathologically proven rectal adenocarcinoma underwent routine high-resolution rectal magnetic resonance imaging (MRI) and IVIM DWI sequences were recruited. The MRI-detected circumferential resection margin (mrCRM) and extramural vascular invasion (mrEMVI) were evaluated. IVIM parameters of the mesorectum adjacent to (MAT) and distant from (MDT) the tumour were measured and compared between and within the prognostic factor groups. ResultsThe positive mrCRM (pMAT < 0.001; pMDT = 0.013) and mrEMVI (pMAT = 0.001; pMDT < 0.001) groups demonstrated higher D values in the MAT and MDT than the corresponding negative groups. Conversely, the positive mrCRM (p = 0.001) and mrEMVI (p < 0.001) groups both demonstrated lower f values in the MAT. Similarly, in the self-comparison between the MAT and MDT in the above subgroups, D showed a significant difference in all subgroups (p < 0.001 for all), and f showed a significant difference in the positive mrCRM (p = 0.001) and mrEMVI (p = 0.002) groups. Moreover, the MAT displayed a higher D* in the positive mrCRM (p = 0.014), negative mrCRM (p = 0.009) and negative mrEMVI groups (p < 0.001).ConclusionThe microstructure of the mesorectum in patients with rectal cancer with poor prognostic status shows changes based on IVIM parameters.