bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescents' attachment, quality of relationships with residential caregivers, and emotion regulation
Authors: Costa Mónica , Tagliabue Semira , Melim Beatriz , Mota Catarina P. , Matos Paula M. 
Published: May 2022

AbstractIntroductionAdolescents in residential care are more likely to report insecure and especially disorganized attachments, which lead to difficulties in emotion regulation and compromise the quality of their interpersonal relationships. In residential care, it is expected that sensitive and responsive caregivers are able to help adolescents regulate their feelings of distress, enabling them to experience a sense of emotional security. The present study sought to analyze the effects of the quality of attachment on emotion regulation and to test the moderating effect of quality of relationship (from adolescents' and caregivers' perspectives) on this association.MethodsThe sample involved 306 adolescents, 12–18 years of age, living in residential care and 70 caregivers.ResultsThe findings underscored the importance of the quality of the relationship with residential caregivers on adolescents' emotion regulation competencies over time. The results also showed that the quality of relationship (emotional closeness) as perceived by the caregivers moderated the association between adolescents' attachment avoidance levels and their emotion regulation strategies.ConclusionsThe results are discussed according to attachment theory, and underscore the role the relationship with caregivers plays in the affective reorganization of adolescents living in residential care.
ERα Signaling in a Subset of CXCL12‐Abundant Reticular Cells Regulates Trabecular Bone in Mice
Authors: Scheffler Julia M , Gustafsson Karin L , Barrett Aidan , Corciulo Carmen , Drevinge Christina , Del Carpio Pons Alicia M , Humeniuk Piotr , Engdahl Cecilia , Gustafsson Jan‐Åke , Ohlsson Claes , Carlsten Hans , Lagerquist Marie K. , Islander Ulrika 
Published: May 2022

ABSTRACTEstrogen has pronounced effects on the immune system, which also influences bone homeostasis. In recent years, stromal cells in lymphoid organs have gained increasing attention as they not only support the regulation of immune responses but also affect bone remodeling. A conditional knockout mouse model where estrogen receptor alpha (ERα) is deleted in CCL19‐expressing stromal cells (Ccl19‐Cre ERαfl/fl mice) was generated and bone densitometry was performed to analyze the importance of stromal cell–specific ERα signaling on the skeleton. Results showed that female Ccl19‐Cre ERαfl/fl mice display reduced total bone mineral density and detailed X‐ray analyses revealed that ERα expression in CCL19‐expressing stromal cells is important for trabecular but not cortical bone homeostasis. Further analysis showed that the trabecular bone loss is caused by increased osteoclastogenesis. Additionally, the bone formation rate was reduced; however, the expression of osteoprogenitor genes was not altered. Analysis of the bone marrow stromal cell compartment revealed a deletion of ERα in a subgroup of CXCL12‐abundant reticular (CAR) cells resulting in increased secretion of the pro‐osteoclastogenic chemokine CXCL12. In conclusion, this study reveals the importance of ERα signaling in CAR cells for bone health. © 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Is there a loophole in Dollo's law? A DevoEvo perspective on irreversibility (of felid dentition)
Authors: Lynch Vincent J. 
Published: May 2022

AbstractThere is a longstanding interest in whether the loss of complex characters is reversible (so‐called “Dollo's law”). Reevolution has been suggested for numerous traits but among the first was Kurtén, who proposed that the presence of the second lower molar (M2) of the Eurasian lynx (Lynx lynx) was a violation of Dollo's law because all other Felids lack M2. While an early and often cited example for the reevolution of a complex trait, Kurtén and Werdelin used an ad hoc parsimony argument to support their. Here I revisit the evidence that M2 reevolved lynx using explicit parsimony and maximum likelihood models of character evolution and find strong evidence that Kurtén and Werdelin were correct—M2 reevolved in E. lynx. Next, I explore the developmental mechanisms which may explain this violation of Dollo's law and suggest that the reevolution of lost complex traits may arise from the reevolution of cis‐regulatory elements and protein−protein interactions, which have a longer half‐life after silencing that protein coding genes. Finally, I present a developmental model to explain the reevolution M2 in E. lynx, which suggest that the developmental programs required for the establishment of serially homologous characters may never really be lost so long as a single instance of the character remains—thus the gain and loss and regain of serially homologous characters, such mammalian molars, may be developmentally and evolutionarily “simple.”
Transcultural adaptation and validation of the Spanish version of the Global Pain Scale
Authors: Ortega‐Avila Ana Belen , Gijon‐Nogueron Gabriel , Cervera‐Garvi Pablo , Guerra‐Marmolejo Cristina , Chicharro‐Luna Esther , Reinoso‐Cobo Andres , Marchena‐Rodriguez Ana 
Published: May 2022

AbstractThe aim of this study was to perform a cross‐cultural adaption and validation of the Global Pain Scale (GPS) to produce a Spanish‐language version (GPS‐Sp) and to determine the psychometric properties of this instrument. The GPS was cross‐culturally translated into Spanish following the guidelines of the International Society for Pharmacoeconomics and Outcomes Research. The initial study population was composed of 384 patients recruited from February to May 2021. All participants were aged at least 18 years and were currently experiencing pain. All gave signed informed consent to take part and completed the Brief Inventory‐Sp and GPS‐Spain questionnaires. Cronbach's ɑ and test/retest reliability values were calculated and floor/ceiling effects analyzed. Construct validity was assessed by confirmatory factor analysis (CFA). The 370 patients included in the final analysis presented the following characteristics: 36.2% were male and 63.8% were female; mean age 42.6 (19–88) years; mean body mass index 24.99. Internal consistency was good. The Cronbach's ɑ for GPS‐Sp was 0.86 and the intraclass correlation coefficient was 0.94 (95% CI; 0.87–0.97). Five main explanatory factors were identified by CFA, which produced the following values: RMSEA = 0.057; CFI = 0.807; GFI = 0.809; NFI = 0.763. No floor/ceiling effect was observed. The GPS‐Sp is a valid, reliable and sensitive instrument for assessing pain in a Spanish‐speaking population and could facilitate pain relief in this population.
The presence of 3D printing in orthopedics: A clinical and material review
Authors: Rodriguez Colon Ricardo , Nayak Vasudev Vivekanand , Parente Paulo E. L. , Leucht Philipp , Tovar Nick , Lin Charles C. , Rezzadeh Kevin , Hacquebord Jacques H. , Coelho Paulo G. , Witek Lukasz 
Published: May 2022

AbstractThe field of additive manufacturing, 3D printing (3DP), has experienced an exponential growth over the past four decades, in part due to increased accessibility. Developments including computer‐aided design and manufacturing, incorporation of more versatile materials, and improved printing techniques/equipment have stimulated growth of 3DP technologies within various industries, but most specifically the medical field. Alternatives to metals including ceramics and polymers have been garnering popularity due to their resorbable properties and physiologic similarity to extracellular matrix. 3DP has the capacity to utilize an assortment of materials and printing techniques for a multitude of indications, each with their own associated benefits. Within the field of medicine, advances in medical imaging have facilitated the integration of 3DP. In particular, the field of orthopedics has been one of the earliest medical specialties to implement 3DP. Current indications include education for patients, providers, and trainees, in addition to surgical planning. Moreover, further possibilities within orthopedic surgery continue to be explored, including the development of patient‐specific implants. This review aims to highlight the use of current 3DP technology and materials by the orthopedic community, and includes comments on current trends and future direction(s) within the field.
Corrosion mechanisms of AZ31 magnesium alloy: Importance of starting pH and its evolution
Authors: Prince Loic , Noirfalise Xavier , Paint Yoann , Olivier Marjorie 
Published: May 2022

AbstractThis article aims at improving the understanding of the corrosion mechanism of AZ31 magnesium alloys during a long period of immersion in an aqueous electrolyte. In particular, the influence of the starting pH of the electrolyte on the oxidation of AZ31 alloy and its evolution due to corrosion phenomena were investigated. Several electrolytes with different pH values containing or not chlorides were used. The electrochemical properties of the metal substrate in these electrolytes were studied as a function of immersion time by electrochemical impedance spectroscopy. The kinetics of the reactions were determined by potentiodynamic polarization as well as dihydrogen evolution measurements by eudiometry. All these tests were carried out while the sample surface and electrolyte volume remained constant. The corrosion products generated on the alloy surface were analyzed by X‐ray photoelectrons spectrometry. This study has shown that the evolution of the corrosion rate and the corrosion products depends greatly on the initial pH and the nature of the used electrolyte. Alkaline electrolyte leads to a passive protective layer that can be locally destroyed by chloride ions. For a neutral chloride electrolyte, the strong increase of the pH due to the magnesium corrosion is not able to form a protective layer by precipitation of corrosion products. The kinetic and the corrosion extent are affected by the pH changes.
Advances in data‐independent acquisition mass spectrometry towards comprehensive digital proteome landscape
Authors: Kitata Reta Birhanu , Yang Jhih‐Ci , Chen Yu‐Ju 
Published: May 2022

AbstractThe data‐independent acquisition mass spectrometry (DIA‐MS) has rapidly evolved as a powerful alternative for highly reproducible proteome profiling with a unique strength of generating permanent digital maps for retrospective analysis of biological systems. Recent advancements in data analysis software tools for the complex DIA‐MS/MS spectra coupled to fast MS scanning speed and high mass accuracy have greatly expanded the sensitivity and coverage of DIA‐based proteomics profiling. Here, we review the evolution of the DIA‐MS techniques, from earlier proof‐of‐principle of parallel fragmentation of all‐ions or ions in selected m/z range, the sequential window acquisition of all theoretical mass spectra (SWATH‐MS) to latest innovations, recent development in computation algorithms for data informatics, and auxiliary tools and advanced instrumentation to enhance the performance of DIA‐MS. We further summarize recent applications of DIA‐MS and experimentally‐derived as well as in silico spectra library resources for large‐scale profiling to facilitate biomarker discovery and drug development in human diseases with emphasis on the proteomic profiling coverage. Toward next‐generation DIA‐MS for clinical proteomics, we outline the challenges in processing multi‐dimensional DIA data set and large‐scale clinical proteomics, and continuing need in higher profiling coverage and sensitivity.
An ultrahigh‐sensitivity microwave angular displacement sensor with a wide dynamic range
Authors: Lin Fu‐Kang , Wang Da‐Wei , Zhao Wen‐Sheng , Yu Yufeng , Qian Cheng 
Published: May 2022

AbstractA microwave angular displacement sensor with dynamic range up to 180° and ultrahigh sensitivity is designed and fabricated. In the proposed sensor, a stator is designed for reference and a rotatable rotor is attached to it to implement real‐time measurement of the rotation angle. As the rotor is attached to the stator, a CSRR‐like resonant structure would be formed, with the resonant frequency linearly changing with the angular displacement. The measurement results show that the resonant frequency of the designed angular displacement sensor increases from 2.398 to 6.348 GHz linearly as the angle varies from 0° to 180°, with an excellent sensitivity of 21.94 MHz/° achieved.
Microfluidic device with a carbonate‐rich hydroxyapatite micro‐coating
Authors: Lui Florence H. Y. , Xu Liangcheng , Michaux Pierrette , Biazik Joanna , Harm Gregory F. S. , Oliver Rema A. , Koshy Pramod , Walsh William R. , Mobbs Ralph J. , Brennan‐Speranza Tara C. , Wang Yu , You Lidan , Sorrell Charles C. 
Published: May 2022

AbstractA contiguous carbonate‐rich hydroxyapatite microcoating in a microfluidic device represents a substrate that has chemical and structural similarity to bone mineral. The present work describes a low‐temperature method to deposit a carbonate‐rich hydroxyapatite microcoating on a glass slide and its incorporation within the microchannels of a microfluidic device. A glass slide is covered/masked with polypropylene‐based tape and CaCO3 nanoparticles are deposited on exposed areas by convective self assembly. The precursor CaCO3 is converted to carbonate‐rich hydroxyapatite by dissolution‐recrystallization in phosphate‐buffered saline. The microcoating is aligned/incorporated within a microchannel when the underlying glass is bonded to a polydimethylsiloxane structure with the device layout. X‐ray diffraction, laser Raman microspectroscopy, and X‐ray photoelectron spectroscopy indicate that the microcoating was comprised of carbonate‐rich hydroxyapatite. Scanning electron microscopy and 3D laser confocal microscopy showed that was comprised of nanocrystalline rod‐like clusters that collectively exhibit a thickness of ∼20 µm. Monocultures/cocultures of osteoblast‐lineage (MC3T3‐E1, MG63) and preosteoclast‐lineage (RAW 264.7) cells were performed. Osteoblast‐lineage cells adhered to the microcoating and deposited an extracellular matrix of collagen fibrils and mineral accretions. Mineralization was detected in/near the inlet wells. The microcoating is analogous to bone mineral and could be applied to various layouts and mineral systems.
Third‐line therapy for overactive bladder in the elderly: Nuances and considerations
Authors: Zillioux Jacqueline , Slopnick Emily A. , Vasavada Sandip P. 
Published: May 2022

AbstractIntroductionOveractive bladder (OAB) disproportionally affects older adults in both incidence and severity. OAB pharmacotherapy is often problematic in the elderly due to polypharmacy, adverse side effect profiles and contraindications in the setting of multiple comorbidities, and concerns regarding the risk of incident dementia with anticholinergic use. The burden of OAB in older patients coupled with concerns surrounding pharmacotherapy options should motivate optimization of nonpharmacologic therapies in this population. At the same time, several aspects of aging may impact treatment efficacy and decision‐making. This narrative review critically summarizes current evidence regarding third‐line OAB therapy use in the elderly and discusses nuances and treatment considerations specific to the population.MethodsWe performed an extensive, nonsystematic evidence assessment of available literature via PubMed on onabotulinumtoxinA (BTX‐A), sacral neuromodulation, and percutaneous tibial nerve stimulation (PTNS) for OAB, with a focus on study in elderly and frail populations.ResultsWhile limited, available studies show all three third‐line therapies are efficacious in older populations and there is no data to support one option over another. BTX‐A likely has a higher risk of urinary tract infection and retention in older compared to younger populations, especially in the frail elderly. PTNS incurs the lowest risk, although adherence is poor, largely due to logistical burdens.ConclusionAdvanced age and frailty should not preclude third‐line therapy for refractory OAB, as available data support their efficacy and safety in these populations. Ultimately, treatment choices should be individualized and involve shared decision‐making.
Different dimensions of decentralization and rural–urban poverty in Pakistan
Authors: Shahid Muhammad , Ahmad Khalil , Kalim Rukhsana 
Published: May 2022

AbstractThe process of decentralization plays a vital role to enhance the welfare of society through the provision of public goods and services. This study investigates the impact of different dimensions of decentralization on rural–urban poverty and total poverty for Pakistan. For empirical analysis, this study uses time‐series data covering the period from 1980 to 2018. The auto‐regressive distributive lag model bounds testing cointegration method is used for long‐run estimation and error correction dynamic for short‐run movements of variables. The results show that fiscal and administrative decentralization are more beneficial for overall and rural–urban poverty reduction. The surprising results of political decentralization increases poverty overall in the case of Pakistan. For poverty reduction, the government should try to reduce the political concentration of elite groups in Pakistan. Moreover, to curtail poverty, government policy should be focused on effective strategies to address inflation and development of GDP per capita growth.
Opportunities and challenges in phenotyping row crops using drone‐based RGB imaging
Authors: Sweet Dorothy D. , Tirado Sara B. , Springer Nathan M. , Hirsch Candice N. , Hirsch Cory D. 
Published: May 2022

AbstractDeveloping the resilient crops of the future will require access to a broad set of tools. While advances in sequencing and marker technologies have facilitated marker‐trait associations and the ability to predict the phenotype of an individual from its genotypic information, other tools such as high‐throughput phenotyping are still in their infancy. Advances in sensors, aeronautics, and computing have enabled progress. Here, we review current platforms and sensors available for top‐down field phenotyping with a focus on unoccupied aerial vehicles (UAVs) and red, green, blue sensors. We also review the ability and effectiveness of extracting traits from images captured using combinations of these platforms and sensors. Improvements in trait standardization and extraction software are expected to increase the use of high‐throughput phenotyping in the coming years and further facilitate crop improvement.
Antitumor mechanism of combination of Angelica gigas and Torilis japonica in LNCaP prostate cancer cells via G1 arrest and inhibition of Wnt/β‐catenin and androgen receptor signaling
Authors: Kim Dong Hee , Im Eunji , Lee Dae Young , Lee Hyo‐Jung , Sim Deok Yong , Park Ji Eon , Ahn Chi‐Hoon , Koo Ja Il , Pak Ji‐Na , Kim Sung‐Hoon 
Published: May 2022

AbstractThe goal of the current study is to assess the antitumor mechanism by the combination (7:3) of Angelica gigas and Torilis japonica (AT) that was found most effective through screening against prostate‐specific antigen (PSA) in LNCaP prostate cancer cells. Here, AT reduced the viability and the number of colonies in androgen‐dependent LNCaP cells more than in androgen independent PC3 and DU145 cells. Also, AT induced G1 phase arrest, cleaved PARP and caspase 3, activated p27 and decreased the expression of Cyclin D1, Cyclin E, cdk2 in LNCaP cells. Furthermore, AT decreased the expression of PSA and androgen receptor (AR) at mRNA and protein levels in LNCaP cells. Interestingly, AT attenuated the expression of AR, PSA and Wnt‐3a and the stability of AR and PSA in LNCaP cells. Furthermore, AT reversed dihydrotestosterone (DHT)‐induced upregulation of AR and PSA in LnCaP cells. Notably, AT disrupted the protein–protein interaction, nuclear translocation and fluorescent expression of β‐catenin and AR in LNCaP cells. Consistently, β‐catenin depletion enhanced the decreased expression of AR in AT treated LNCaP cells. Taken together, our findings highlight evidence that AT suppresses the proliferation of LNCaP cells via G1 arrest and inhibition of β‐catenin and AR as a potential anticancer agent.
A bootstrap method for the measurement error estimation in Gauge R&R$R{\&}R$ Studies
Authors: Celano Giovanni 
Published: May 2022

AbstractA measurement system fit for use is an essential resource to perform quality control activities: its assessment must be carried out periodically to quantify its bias(location) and precision(width) error to qualify it for the purpose it is used. In particular, the measurement system capability must be determined to evaluate how much of the observed variability originates from the gauge's precision error. Gauge Repeatability and Reproducibility () studies are aimed at getting a reliable estimate of the precision error of the measurement system. The outcome of a Gauge study are point estimates and confidence intervals of the precision error components and related measurement capability metrics. Here, a general bootstrap‐based procedure is proposed to get confidence interval estimations of the measurement error and its components from a Gauge () study for continuous observations carried out with either the Average and Range (ARGG) control chart or the experimental design method. An application of the proposed bootstrap‐method is presented for a dataset of observations.
Fusion of multimodality image and point cloud for spatial surface registration for knee arthroplasty
Authors: Liu Yanjing , Yao Demin , Zhai Zanjing , Wang Hui , Chen Jiayi , Wu Chuanfu , Qiao Hua , Li Huiwu , Shi Yonghong 
Published: May 2022

AbstractBackgroundImage‐guided computer‐aided navigation system is an indispensable part of computer assisted orthopaedic surgery. However, the location and number of fiducial markers, the time required to localise fiducial markers in existing systems affect their effectiveness.MethodThe study proposed that spatial surface registration between the point cloud on the surface of the fusion model based on preoperative knee MRI and CT images and the point cloud on the cartilage surface captured by intraoperative laser scanner could solve the above limitations.ResultsThe experimental results show that the registration error of the method is less than 2 mm, but the total time from scanning the point cloud on patient's cartilage surface to registering it with the point cloud in preoperative image space is less than 2 min.ConclusionThe method achieves the registration accuracy similar to existing methods without selecting anatomical corresponding points, which is of great help to the clinic.
The impact of artificial intelligence on users' entrepreneurial activities
Authors: Li Xueling , Zhang Xiaoyan , Liu Yuan , Mi Yuanying , Chen Yong 
Published: May 2022

AbstractThis study explores the impact of artificial intelligence (AI) on user entrepreneurs, driving factors and user entrepreneurship process combined with its characteristics and development trends. Moreover, this study sorts out the logic of user entrepreneurship change in the AI era. This study achieves four findings. First, AI contributes to entrepreneurs by collecting large user data and intelligently analysing them to obtain optimal entrepreneurial judgements and decisions. Second, entrepreneurs may use AI systems to understand users' potential needs and get user demand information (e.g. more accurate and more major shortcomings of the products). Third, AI assists entrepreneurs in obtaining robust data of product users, including leading and ordinary users, for a wider audience. Fourth, AI replaces the original intergenerational product replacement model with intermittent and periodic characteristics for entrepreneurial activities and reforms the three‐stage user entrepreneurial process: product element deconstruction, product verification matching and innovative product commercialization. This study provides a feasible direction for the key research issues.