bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Zhenwu Decoction in the Treatment of Diabetic Nephropathy: A Systematic Review and Meta-Analysis
Authors: Lv Xialin , Zhou Min , Liu Xiu , Xiang Qin , Yu Rong 
Published: November 2022

Objective. To perform a systematic evaluation of the clinical efficacy and safety of Zhenwu decoction (ZWD) for the treatment of diabetic nephropathy (DN). Methods. PubMed, the China National Knowledge Infrastructure (CNKI), the China Science and Technology Journal Database (VIP), the Chinese Biomedical Literature Database (CBM), and the WanFang databases were searched, and a systematic review and meta-analysis of randomized controlled trials (RCTs) were subsequently conducted to compare the efficacy and safety of ZWD combined with conventional Western medicine (CWM) to conventional therapy alone in the treatment of DN. The Cochrane Handbook for Systematic Reviews of Interventions and GRADE criteria were utilized to assess the quality of the included literature, and RevMan 5.3 software was used for statistical analysis. Results. 13 randomized controlled trials were included, involving 1347 patients with diabetic nephropathy assigned into two subgroups according to the disease duration. The results revealed that compared with conventional therapy alone, ZWD combined with CWM treatment significantly improved the total effective rate (OR = 3.88, 95% CI = (2.87, 5.26),

P

< 0.00001). Furthermore, ZWD combination therapy also decreased fasting blood glucose (MD = −0.72, 95% CI = (−0.97, −0.48),

P

< 0.00001), BUN (MD = −1.92, 95% CI = (−3.19, −0.64),

P

= 0.003), 24-hour urine protein (MD = −0.48, 95% CI = (−0.57, −0.39),

P

< 0.00001), and serum creatinine levels (MD = −51.17, 95% CI = (−66.95, −35.39),

P

< 0.00001). However,there was no statistical significance in the effect of combination therapy on creatinine clearance (MD = −0.64, 95% CI = [−8.21,6.92], P = 0.87). However, there was no statistical significance in the effect of combination therapy oncreatinine clearance (MD =−0.64, 95% CI=[−8.21,6.92], P=0.87). Conclusion. ZWD combined with CWM outperformed conventional Western medicine in DN treatment. However, further investigations via multicenter RCTs with rigorous designs and higher quality are still warranted.
Penerapan Analisis Regresi Nonparametrik dengan Pendekatan Regresi Kernel dan Spline
Authors: Sihombing Pardomuan Robinson , Famalika Ade 
Published: November 2022

Penelitian ini bertujuan untuk menerapkan regresi nonparametrik menggunakan regresi kernel dan spline. Regresi kernel menggunakan metode penaksir Nadaraya-Watson (NWE) dan penaksir Polinomial Lokal (LPE), sedangkan untuk regresi spline adalah smoothing spline dan b-splines. Metode ini diterapkan dalam menganalisis pola hubungan Pertumbuhan Produksi Industri (PPI) dan Tingkat Pajak Perusahaan (TPP). Hasil pengepasan kurva (fitting curve) menunjukkan bahwa model regresi nonparametrik terbaik adalah model regresi b-splines dengan degree 2 dan jumlah knot 5. Hal ini dikarenakan model regresi b-splines memiliki kurva yang halus dan terlihat lebih mengikuti sebaran data dibandingkan kurva model regresi lainnya. TPP berpengaruh signifikan negatif terhadap PPI artinya kenaikan TPP akan menurunkan PPI. Oleh sebab itu perlu kebijakan yang komprehensif dalam menerapkan nilai TPP agar tetap dapat meningkatkan produktivitas industri.
Mengukur Output Gap Ekonomi Maluku Utara (Pendekatan Hodrick-Prescott Filter)
Authors: Jacob Jufri , Waibot Zulkifly 
Published: November 2022

Development anywhere will always be faced with fluctuating conditions or the ups and downs of economic growth. In the discourse "New Neo-Classical Synthesis" which by (Hubbard, 2014; Gordon, 2014; Mitchell, 2019 and Insukindro, 2020), sees economic fluctuations that can lead to recession and expansion. How to measure the output gap or economic fluctuation that occurred in North Maluku Province and its relationship with economic indicators.
Estimation of economic fluctuations uses the Hodrick-Prescott Filter method, which is an econometric method to describe the frequency of time series data becoming trends in an economic cycle. The results showed that North Maluku's economic fluctuations were actually dominated by economic recessions rather than expansion. In the first quarter of 2020, if you use the standard macroeconomic approach, there will still be economic expansion fluctuations (3.06), but the New Neo-Classical Synthesis method since the first quarter has experienced an economic recession (-1.42). Meanwhile, the movement patterns are unidirectional or procyclic, there are also opposites or contersiclic.
Manganese-Enhanced Magnetic Resonance Imaging in Takotsubo Syndrome
Authors: Singh Trisha , Joshi Shruti , Kershaw Lucy E. , Baker Andy H. , McCann Gerry P. , Dawson Dana K. , Dweck Marc R. , Semple Scott I. , Newby David E. 
Published: November 2022

Background:
Takotsubo syndrome is an acute cardiac emergency characterized by transient left ventricular systolic dysfunction typically following a stressful event. Despite its rapidly rising incidence, its pathophysiology remains poorly understood. Takotsubo syndrome may pass unrecognized, especially if timely diagnostic imaging is not performed. Defective myocardial calcium homeostasis is a central cause of contractile dysfunction and has not been explored in takotsubo syndrome. We aimed to investigate myocardial calcium handling using manganese-enhanced magnetic resonance imaging during the acute and recovery phases of takotsubo syndrome.

Methods:
Twenty patients with takotsubo syndrome (63±12 years of age; 90% female) and 20 volunteers matched on age, sex, and cardiovascular risk factors (59±11 years of age; 70% female) were recruited from the Edinburgh Heart Centre between March 2020 and October 2021. Patients underwent gadolinium and manganese-enhanced magnetic resonance imaging during index hospitalization with repeat manganese-enhanced magnetic resonance imaging performed after at least 3 months.

Results:

Compared with matched control volunteers, patients had a reduced left ventricular ejection fraction (51±11 versus 67±8%;
P
<0.001), increased left ventricular mass (86±11 versus 57±14 g/m
2
;
P
<0.001), and, in affected myocardial segments, elevated native T1 (1358±49 versus 1211±28 ms;
P
<0.001) and T2 (60±7 versus 38±3 ms;
P
<0.0001) values at their index presentation. During manganese-enhanced imaging, kinetic modeling demonstrated a substantial reduction in myocardial manganese uptake (5.1±0.5 versus 8.2±1.1 mL/[100 g of tissue ·min], respectively;
P
<0.0001), consistent with markedly abnormal myocardial calcium handling. After recovery, left ejection fraction, left ventricular mass, and T2 values were comparable with those of matched control volunteers. Despite this, native and postmanganese T1 and myocardial manganese uptake remained abnormal compared with matched control volunteers (6.6±0.5 versus 8.2±1.1 mL/[100 g of tissue ·min];
P
<0.0001).

Conclusions:
In patients with takotsubo syndrome, there is a profound perturbation of myocardial manganese uptake, which is most marked in the acute phase but persists for at least 3 months despite apparent restoration of normal left ventricular ejection fraction and resolution of myocardial edema, suggesting abnormal myocardial calcium handling may be implicated in the pathophysiology of takotsubo syndrome. Manganese-enhanced magnetic resonance imaging has major potential to assist in the diagnosis, characterization, and risk stratification of patients with takotsubo syndrome.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04623788.
Noncanonical Form of ERAD Regulates Cardiac Hypertrophy
Authors: Blackwood Erik A. , MacDonnell Lauren F. , Thuerauf Donna J. , Bilal Alina S. , Murray Victoria B. , Bedi Kenneth C. , Margulies Kenneth B. , Glembotski Christopher C. 
Published: November 2022

Background:
Cardiac hypertrophy increases demands on protein folding, which causes an accumulation of misfolded proteins in the endoplasmic reticulum (ER). These misfolded proteins can be removed by the adaptive retrotranslocation, polyubiquitylation, and a proteasome-mediated degradation process, ER-associated degradation (ERAD), which, as a biological process and rate, has not been studied in vivo. To investigate a role for ERAD in a pathophysiological model, we examined the function of the functional initiator of ERAD, valosin-containing protein–interacting membrane protein (VIMP), positing that VIMP would be adaptive in pathological cardiac hypertrophy in mice.

Methods:
We developed a new method involving cardiac myocyte-specific adeno-associated virus serovar 9–mediated expression of the canonical ERAD substrate, TCRα, to measure the rate of ERAD, ie, ERAD flux, in the heart in vivo. Adeno-associated virus serovar 9 was also used to either knock down or overexpress VIMP in the heart. Then mice were subjected to transverse aortic constriction to induce pressure overload–induced cardiac hypertrophy.

Results:
ERAD flux was slowed in both human heart failure and mice after transverse aortic constriction. Surprisingly, although VIMP adaptively contributes to ERAD in model cell lines, in the heart, VIMP knockdown increased ERAD and ameliorated transverse aortic constriction–induced cardiac hypertrophy. Coordinately, VIMP overexpression exacerbated cardiac hypertrophy, which was dependent on VIMP engaging in ERAD. Mechanistically, we found that the cytosolic protein kinase SGK1 (serum/glucocorticoid regulated kinase 1) is a major driver of pathological cardiac hypertrophy in mice subjected to transverse aortic constriction, and that VIMP knockdown decreased the levels of SGK1, which subsequently decreased cardiac pathology. We went on to show that although it is not an ER protein, and resides outside of the ER, SGK1 is degraded by ERAD in a noncanonical process we call ERAD-Out. Despite never having been in the ER, SGK1 is recognized as an ERAD substrate by the ERAD component DERLIN1, and uniquely in cardiac myocytes, VIMP displaces DERLIN1 from initiating ERAD, which decreased SGK1 degradation and promoted cardiac hypertrophy.

Conclusions:
ERAD-Out is a new preferentially favored noncanonical form of ERAD that mediates the degradation of SGK1 in cardiac myocytes, and in so doing is therefore an important determinant of how the heart responds to pathological stimuli, such as pressure overload.
Prayer, Magic and Memory in Plotinus’ Treatise on the Soul (Enneads iv 4 [28], 30-45)
Authors: Helleman Wendy Elgersma 
Published: November 2022

Abstract
In an environment where astrology was widely respected, Plotinus accepted the role of heavenly bodies in answering prayer. Considering them divine, he denied them the use of memory (iv 4, 6-8); how then could he explain response to prayer received after an interval of time? Plotinus was also concerned to deny attributing intentionality in any response given, for good or evil, since that would make the astral deities responsible also for morally dubious answers. In his treatment of the issue in this passage, Plotinus draws on a lengthy earlier discussion of the role of memory in the soul’s thinking and knowing (iv 3, 25-iv 4, 12), as associated primarily with that which exists in time and is characterized by αἴσθησις, i.e., the lower soul belonging to the composite living being (iv 3, 25.12-14; iv 4, 16-17). If astral deities have bodies, these are of a highly refined fiery nature, and can be affected only inasmuch as they participate in the cosmic circuit. What suppliants may regard as intentional response must therefore be understood as the effect of a type of ‘linking’ of the universe as a living organism in which all parts are coordinated in an interrelationship characterized by sympathy. This is why answers to prayer represent no more than the unintended reaction of natural forces in the universe, the very same forces also responsible for effective use of magic. If Plotinus does not assign much value to prayer, he does recognize that, as with magic, such incantations may have a harmful effect, if only for the lower soul. He therefore warns the wise person to guard against such outcomes by focusing the soul in its contemplation of what is higher, i.e., its inner life.
Derivation of New Daily Rainfall Values from TAO 1-Min Rain Gauge Data
Authors: Cook Werner E. , Greene J. Scott 
Published: November 2022

Abstract
Daily rainfall accumulation estimates have been derived from 1-min volume data collected via self-syphon rain gauges deployed in the Tropical Atmosphere–Ocean (TAO) array of oceanographic buoys. The underlying high-resolution volume data were obtained directly from the Global Tropical Moored Buoy Array (GTMBA) Project Office of NOAA/Pacific Marine Environmental Laboratory. The derived accumulations have been incorporated into the Pacific Rainfall (PACRAIN) database as estimated daily values to augment existing sea level oceanic rainfall records gathered using traditional rain gauges. They have also been included in the PACRAIN historical, monthly gridded rainfall product. The methodology presented, which employs differencing of least squares–regressed sensor levels about 0000 UTC and rain gauge syphon events, is shown to offer improved error characteristics over the methodology used to compute previously published GTMBA rain rates. In particular, the PACRAIN method yields larger coefficients of determination and smaller standard errors than the duplicated GTMBA method when applied to synthetic rainfall data with noise magnitude and decorrelation times encompassing those observed in the real 1-min data. These results are shown to be consistent with mathematical expectations. Sources of instrument and catchment errors, as well as evaporation, are discussed in the context of their potential effects on accumulation estimates for periods of a day or longer.

Significance Statement
In this paper, we describe the derivation of daily rainfall amounts from raw rain gauge data obtained from buoy-mounted rain gauges. These new accumulation estimates expand the store of rainfall estimates from locations approximating the open-ocean conditions of the tropical Pacific Ocean. The derivation technique we describe exhibits better performance than the method used to generate previously published estimates using the same dataset.
The impact of the COVID-19 pandemic and earthquake on mental health of persons with severe mental illness: A survey study among people receiving community mental health care versus treatment as usual in Croatia
Authors: Levaj Sarah , Medved Sara , Grubišin Jasmina , Tomašić Lea , Brozić Kristina , Shields-Zeeman Laura , Bolinski Felix , Rojnic Kuzman Martina 
Published: November 2022

Background: The COVID-19 pandemic led to the disruption of mental health services in most countries. Croatia has been developing and strengthening its mental health system, including the introduction of community mental health teams (CMHT) for persons with severe mental illness (SMI), whose implementation was ongoing during the pandemic through the RECOVER-E project. Aims: The aim of this study was to assess the differences in mental health outcomes, perceived social support and healthcare utilization in the group of participants receiving treatment as usual (TAU group) compared to the group receiving TAU and additional care by the CMHT (CMHT group) during the COVID-19 pandemic and two earthquakes. Method: This is a cross-sectional survey administered among 90 participants with SMI at two time points: in May/June 2020 (first COVID-19 wave, earthquake) and in December 2020/January 2021 (second COVID-19 wave, earthquake). Results: A significantly larger proportion of participants from the CMHT group visited the general practitioners in both waves of COVID-19 (first wave: CMHT 72.1%, TAU 44.2%, p = .009; second wave: CMHT 91.1%, TAU 64.1%, p = .003), as well as psychiatric services in the second wave (CMHT 95.3%, TAU 79.5%, p = .028). The use of long-acting injectables was also more frequent in the CMHT group ( p = .039). Furthermore, analysis of the first wave showed higher perceived support of significant others ( p = .004) in the CMHT group. We did not identify any differences in mental health outcomes between groups in either wave. Conclusions: While mental health outcomes did not differ between TAU and CMHT group, people in CMHT used services and treatments more frequently than those in TAU during the pandemic, which may indicate that CMHT services enable the continuity and accessibility of care for people with SMI under the circumstances where standard care is interruped (for example pandemic, disaster conditions).
A novel model for predicting mortality in the management of deep neck infections
Authors: Tao Xiaoyao , Hua Hongting , Liu Yehai 
Published: November 2022

Objectives Deep neck infections (DNIs) are a common and intractable disease encountered in ENT clinics that impose a significant medical and financial burden on affected individuals and their families. However, insufficient data are currently available for predicting outcomes in cases of DNI. The present study thus sought to develop a novel model capable of predicting treatment outcomes of DNI patients just using indicators at the visit. Methods Patients with DNIs treated from 2010 to 2022 were included in the present study. Patient data were retrospectively collected from medical records. Risk factors associated with mortality were identified using logistic regression models. A predictive model was constructed based on odds ratios for factors calculated using a multivariate regression model. Results In total, 153 patients were enrolled in the present study. Risk factors associated with mortality included age >50 years, residence in a rural area, dyspnea at visit, the involvement of multiple infected sites, serum albumin<34 g/L, renal insufficiency, mediastinitis, pulmonary infection, and septic shock. A multivariate regression model revealed that mediastinitis (OR: 7.308, P < 0.001), serum creatinine>95 μmol/L (OR: 23.363, P < 0.05), and serum albumin<34 g/L (OR: 13.837, P < 0.05) were independent predictors of mortality in deep neck infection patients, with serum creatinine>95 μmol/L being particularly critical to the outcomes. Diabetes was not the predictor of mortality but was associated with long-term hospitalization ( P < 0.001). Conclusions In summary, the model constructed in the present study was capable of estimating the potential for poor outcomes in DNI patients before the initiation of treatment. These findings may help improve doctor–patient communication, especially for those struggling financially.
Belief changes associated with psychedelic use
Authors: Nayak Sandeep M. , Singh Manvir , Yaden David B. , Griffiths Roland R. 
Published: November 2022

Background: Psychedelic use is anecdotally associated with belief changes, although few studies have tested these claims. Aim: Characterize a broad range of psychedelic occasioned belief changes. Survey: A survey was conducted in 2374 respondents who endorsed having had a belief changing psychedelic experience. Participants rated their agreement with belief statements Before and After the psychedelic experience as well as at the time of survey administration. Results: Factor analysis of 45 belief statements revealed five factors: “Dualism,” “Paranormal/Spirituality,” “Non-mammal consciousness,” “Mammal consciousness,” and “Superstition.” Medium to large effect sizes from Before to After the experience were observed for increases in beliefs in “Dualism” (β = 0.72), “Paranormal/Spirituality” (β = 0.90), “Non-mammal consciousness” (β = 0.72), and “Mammal consciousness” (β = 0.74). In contrast, negligible changes were observed for “Superstition” (β = −0.18).). At the individual item level, increases in non-physicalist beliefs included belief in reincarnation, communication with the dead, existence of consciousness after death, telepathy, and consciousness of inanimate natural objects (e.g., rocks). The percentage of participants who identified as a “Believer (e.g., in Ultimate Reality, Higher Power, and/or God, etc.)” increased from 29% Before to 59% After.” At both the factor and individual item level, higher ratings of mystical experience were associated with greater changes in beliefs. Belief changes assessed after the experience (an average 8.4 years) remained largely unchanged at the time of survey. Conclusions: A single psychedelic experience increased a range of non-physicalist beliefs as well as beliefs about consciousness, meaning, and purpose. Further, the magnitude of belief change is associated with qualitative features of the experience.
The distinct experience of supportive care needs among cervical cancer patients: A qualitative study
Authors: Dhakal Kamala , Wang Panpan , Mboineki Joanes Faustine , Getu Mikiyas Amare , Chen Changying , Shrestha Daya Laxmi 
Published: November 2022

Introduction: Patients with cervical cancer report experiencing physical, psychological, economic, and social problems daily. An exploration of supportive care needs is important for patients and their families to cope with diagnosis, treatment, recovery or even death. Objective: This study explores the perceived supportive care needs of Nepali patients with cervical cancer who are undergoing cancer treatment. Methods: A descriptive qualitative research design was utilized with semi-structured interviews to probe patients with cervical cancer’s supportive care needs. The study was conducted at a cancer-specific hospital in Nepal. Purposive sampling was used to recruit 30 patients with cervical cancer. Qualitative thematic analysis techniques were employed to identify the supportive care needs of Nepalese patients with cervical cancer. Results: Supportive care needs were identified with five main themes and sixteen sub-themes: 1) psychological trauma (regret on delaying medical consultation, fear of disease, death and dying, ambivalence about the future and treatment, feeling of loss, caring/rearing of children, feeling and burden to partner/family); 2) financial distress (loss of income and challenges with treatment costs); 3) sexual disharmony; 4) physical dependency on others for day-to-day care and; 5) hunger for information (cause of disease, prognosis of disease, dietary counseling, and information on sexuality). Conclusion: Recognizing the supportive care needs of patients with cervical cancer during treatment by health care professional and family members is vital to facilitate optimal care at the hospital and home for overall improvement in the patient’s quality of life. Acknowledgment that the expensive treatment regime creates an economic and psychological burden for the patients.