bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of occupational radiation doses when decommissioning nuclear power plants
Authors: Lee Eun Ji , Kong Tae Young , Kim Seong Jun , Choi Wo Suk , Son Jin Ho , Song Chang Ju , Kim Hwa Pyoung , Kim Si Young , Cho Moonhyung , Kim Hee Geun 
Published: October 2022

AbstractKori 1, the first commercial reactor in Korea, was permanently shut down in 2017 and is preparing for decommissioning in the mid‐2020s. Although Kori 1 is shut down, some radiation sources remain in the system; as such, the dismantling workers are exposed to radiation until decommissioning is completed. Unexpected radiation events have been reported in some decommissioning nuclear power plants (NPPs), which resulted in additional radiation exposure to workers and significant financial losses due to delays in the decommissioning schedule. Hence, an appropriate radiation protection program must be established to minimize radiation exposure as well as the economic burden. In this study, radiation doses from precedent decommissioning NPPs worldwide are compared with those estimated from Kori 1 to determine dose reduction measures that can achieve radiation exposure as low as reasonably achievable to decommissioning workers.
Short‐term prediction of photovoltaic power generation based on neural network prediction model
Authors: Chai Mu , Liu Zhenan , He Kuanfang , Jiang Mian 
Published: October 2022

AbstractReal‐time monitoring and accurate prediction of photovoltaic (PV) power generation operation parameters are essential to ensure stable operation. In this paper, a set of online PV power generation parameter measurement and monitoring devices characterized by simple structure, high sampling accuracy, small data fluctuations, and ease of measurement, are designed. Sensors based on the zero‐flux principle are employed in the real‐time collection of the output electrical signals in the process of PV power generation, realizing the accurate collection of electric parameter signals. Next, the basic structure and working principle of PV cells are analyzed, a mathematical model of PV cells for engineering purposes is established, a wavelet neural network is selected to predict the short‐term PV power generation, and particle swarm optimization and adding momentum are used to optimize the weight of wavelet neural network (WNN) as well as the parameters of the wavelet basis function. Finally, the historical power generation data and meteorological data of the power station are taken as the training samples to train and simulate the prediction sub‐models of different weather types to verify the effectiveness and accuracy of the PV power generation short‐term prediction model for optimizing the WNN based on the particle swarm optimization algorithm. The research results of this paper can realize real‐time monitoring of the output parameters and accurate prediction and evaluation of power generation during the operation of the PV‐power‐generation system.
Staged multicluster hydraulic fracture propagation mechanism and its influencing factors in horizontal wells for CBM development
Authors: Zhang Cun , Song Ziyu , Zhao Yixin 
Published: October 2022

AbstractStaged multicluster fracturing (SMCF) is crucial for the low‐permeability coalbed methane (CBM) reservoirs development. To reveal the fracture propagation mechanism and characteristics in SMCF and select appropriate hydraulic fracturing parameters, this study considers CBM exploitation in the Shizhuang block, Qinshui Basin in China as the engineering background. Then, XSite hydraulic fracturing software based on the discrete lattice theory and synthetic rock mass method is used to construct a three‐dimensional model. The influence mechanisms of the cluster spacing (CS) and lateral pressure coefficient (LPC) on the fractures propagation characteristics were investigated. With an increase in the CS, the stress interference between fractures gradually weakens, and the fracture deflection also decreases. Both the stimulated reservoir area (SRA) and fracture aperture of a single cluster increase with an increase in CS, but the SRA and fracturing efficiency exhibit limited growth when the CS is greater than 15 m. The SRA decreases exponentially with an increase in LPC. When the LPC increases from 0.4 to 1.4, the SRA decreases by 74.2%. The LPC plays a decisive role in the fracture propagation direction. When the LPC reaches 1.4, the fractures propagate along the horizontal direction. With an increase in LPC, the fracturing fluid pressure increases linearly, and the fracturing efficiency decreases exponentially. The results of this study reveal the fracture propagation law of SMCF and can provide a reference for engineering applications. In the SMCF at the 3# coal seam of the Shizhuang block, the CS can be set to approximately 15 m, and the CS can be appropriately reduced when the LPC is large.
Alcohol extracts of Chinese bayberry branch induce S‐phase arrest and apoptosis in HepG2 cells
Authors: Zheng Yuanyuan , Yu Zheping , Li Yougui , Zhong Shi , Sun Yuqing , Sun Li , Zheng Xiliang , Qi Xingjiang , Zhang Shuwen 
Published: October 2022

AbstractThe alcohol extracts of Chinese bayberry (Myrica rubra) branches (MRBE) are rich in flavonoids which have a variety of medicinal benefits, but their effects on human HepG2 were unknown. In this study, the effects of MRBE on HepG2 cell growth and its potential for inhibiting cancer were explored. The results displayed that MRBE inhibited HepG2 proliferation both by arresting cells in S phase and promoting apoptosis. Quantitative reverse‐transcription PCR (qRT‐PCR), western blotting, and immunofluorescence showed that MRBE induced S‐phase arrest by upregulating p21, which in turn downregulated cyclin and cyclin‐dependent kinase messenger RNA (mRNA) and protein. Apoptosis was induced by blocking the expression of BCL‐2 and suppression of the Raf/ERK1 signaling pathways. These results indicated that MRBE may have the potential for treatment of human liver cancer, highlighting novel approaches for developing new pharmacological tools for the treatment of this deadly type cancer. Meanwhile, it provides a new direction for the medicinal added values of Chinese bayberry, which helped to broaden the diversified development of its industry chain.
Delineation of water flow paths in a tropical Andean headwater catchment with deep soils and permeable bedrock
Authors: Lahuatte Braulio , Mosquera Giovanny M. , Páez‐Bimos Sebastián , Calispa Marlon , Vanacker Veerle , Zapata‐Ríos Xavier , Muñoz Teresa , Crespo Patricio 
Published: October 2022

AbstractTraditional hydrometric data combined with environmental tracers such as water stable isotopes contributes to improve the understanding of catchment hydrology. Nevertheless, the application of isotopic tracers in headwater catchments of the tropical Andes with deep soils and permeable parent material influenced by recent volcanism remains limited. In this study, the stable isotopic composition of precipitation, soil water, wetlands, and streamflow was studied to provide insights into the hydrology of a small tropical Andean catchment with deep and permeable volcanic soils, ash layers, and fractured bedrock resulting from Holocene volcanic activity. Although local precipitation forms under isotopic equilibrium conditions, the stable isotopic composition of precipitation is influenced by atmospheric moisture recycling processes. The spatial and temporal variability of isotopic signals and the analysis of inverse transit time proxies (ITTPs) of surface (streamflow) and subsurface (soil and wetlands) waters indicate that vertical flow paths through the deep volcanic ash soils are dominant across the catchment. The strongly damped isotopic composition of these waters points to high soil and wetlands water storage, increasing the transit time or age of stream water in the hydrological system. These findings indicate that water mobilizing through subsurface flow paths–that is, volcanic soils, ash layers, and cracks in the fractured bedrock resulting from Holocene volcanism–is the main contributor to streamflow generation. Comparison with previously published work from Andean catchments and other volcanic areas shows the diversity of hydrological conditions that can be found as a result of pedological and lithological differences shaped by volcanic activity. Therefore, site‐specific strategies may be needed to improve water resources management.
Using particle size distributions to fingerprint suspended sediment sources—Evaluation at laboratory and catchment scales
Authors: Lake Niels F. , Martínez‐Carreras Núria , Shaw Peter J. , Collins Adrian L. 
Published: October 2022

AbstractApplications of sediment source fingerprinting studies are growing globally despite the high costs and workloads associated with the analyses of conventional fingerprint properties on target sediment samples collected using traditional methods. To this end, there is a need to test new fingerprint properties that can overcome these challenges. Sediment particle size could potentially contribute here since it is relatively easy to measure but, until now, has rarely been deployed as a fingerprint itself. Instead, particle size has been used to ensure that source and target sediment samples are more directly comparable on the basis of the fingerprints used. Accordingly, this work examined whether particle size distributions (PSDs) could be used as a reliable fingerprint for apportioning sediment sources, in combination with a grain size un‐mixing model. Application of PSDs as a fingerprint was tested at two scales: (i) in a laboratory setting where soil samples with known PSDs were used to generate artificial mixtures to evaluate un‐mixing model results, and (ii) a catchment setting comparing PSDs in a confluence‐based approach to test if downstream target sediment PSDs could be un‐mixed into the contributions of sediment coming from an upstream and a tributary sampling site. Laboratory results showed that the known proportions of the two, three and four soil samples in the artificial mixtures were predicted accurately using the AnalySize grain size un‐mixing model, giving average absolute errors of 9%, 8% and 6%, respectively. Catchment results showed variable performances when comparing un‐mixing results with sediment budget estimations, with the best results obtained at higher discharge values during storm runoff events. Overall, our results suggest the potential of using PSDs for estimating contributions of sediment sources delivering SS with distinct PSDs when sources are located at short distance to the downstream sampling site.
Feasibility of implementing cytology‐based cervical cancer screening national program in Lebanon: A pilot study
Authors: Seoud Muhieddine , Jaafar Iman , Hamadeh Randa , Ammar Walid , Atallah David , El‐Kak Faysal 
Published: October 2022

AbstractObjectiveTo review our national cervical cancer screening program using existing Ministry of Public Health primary healthcare centers (PHCs) and report the impact of women's knowledge, attitude, behavior, and practices on screening uptake and outcome.MethodsA cross‐sectional study on cervical cancer screening offered to sexually active Lebanese women aged 21 years and above visiting PHCs. Exclusions were history of complete hysterectomy, gynecologic cancers, and current pregnancy. Data were collected through a questionnaire and conventional cervical smear performed by trained healthcare providers and sent to one centralized cytopathology laboratory.ResultsOf 12 273 eligible women, 1.7% had an abnormal cervical smear test including 161 atypical squamous cells (ASC) of undetermined significance, 6 atypical glandular cells of undetermined significance, 16 low‐grade squamous intraepithelial lesion (SIL), 17 ASC—cannot rule out high‐grade SIL, 11 high‐grade SIL, and one invasive carcinoma. Knowledge and attitudes significantly affected participation in screening; women lacking awareness had rarely undergone a cervical smear.ConclusionIn Lebanon, cytology‐based cervical cancer screening is feasible within the PHCs. Positive screen incidence was low. Despite previous campaigns, a low level of knowledge persists, and affects women's com with the screening guidelines. Advocacy and awareness activities by key healthcare providers may help to improve participation.
Concurrent anorectal and cervical cytology in women with positive and negative cervical smear test results: A cross‐sectional study
Authors: Tehranian Afsaneh , Ghahghaei‐Nezamabadi Akram , Seifollahi Akram , Mansouri Parisa , Maleki‐Hajiagha Arezoo , Aghajani Reyhaneh 
Published: October 2022

AbstractObjectiveConsidering the exponentially growing concerns about the increase of anal cancer rates in women with human papillomavirus (HPV) infection and cervical intraepithelial neoplasia, the authors evaluated concurrent anorectal and cervical cytology in women with positive and negative cervical smear tests.MethodThe current investigation was designed as a cross‐sectional study conducted in Arash Women's Hospital, Tehran, Iran, between November 2020 and November 2021. Cervical cytology, HPV test, and anal cytology samples were prepared. Then women with abnormal cervical cytology and/or positive high‐risk HPV were referred to a colposcopy clinic for further evaluation.ResultsFive hundred and forty‐three women were recruited during the study period. These women were divided into two groups of positive cervical cytology (n = 161) and negative cervical cytology (n = 382). There were no cases of anal intraepithelial neoplasia in either group. Negative anal cytology was reported in 99 (61.5%) of participants with a positive cervical cytology and 254 (66.7%) of participants with a negative cervical cytology. A total of 62 (38.5%) anal samples in the positive group and 127 (33.3%) in the negative group were unsatisfactory for further evaluation.ConclusionWe were unable to show any correlation between abnormal cervical cytology, dysplasia, or cervical high‐risk HPV with anal abnormal cytology.
Experiences of women with advanced cervical cancer before starting the treatment: Systematic review of qualitative studies
Authors: Reis Bruna Sena , Nogueira Cristiane Matos , Meneses Aerica de Figueiredo Pereira , Mellado Bruna Helena , Candido dos Reis Francisco José 
Published: October 2022

AbstractBackgroundAdvanced stage and high mortality are characteristics of cervical cancer in developing countries. Comprehension of the diagnosis itinerary is one of the main strategies to control the disease impact.ObjectivesTo identify reasons for the delay in diagnosing symptomatic cervical cancer according to the patient's perspectives reported in qualitative studies. We searched four databases (PubMed, Embase, CINAHL, and Web of Science).Selection criteriaWe included qualitative studies of women with advanced cervical cancer that explored their experiences before treatment. We excluded unoriginal, non‐qualitative, and duplicated studies.Data collection and analysisWe selected 39 articles for a full‐text reading and included 15 in the present review. We chose the Consolidated Criteria for Reporting Qualitative Research (COREQ) for quality assessment and The Model of Pathways to Treatment to guide the codifying process.Main resultsFour main themes emerged from the synthesis: (1) Health‐seeking motivators; (2) Obstacles to seeking medical care; (3) Diagnosis delay; and (4) Coping with the disease. These themes were derived from patients' personal knowledge and beliefs, social relationships, socioeconomic status, and healthcare system characteristics.ConclusionsIndividual behavior, social factors, and healthcare organization contribute to the delay in diagnosing advanced cervical cancer.
The breakthrough and the future: CD20 chimeric antigen receptor T‐cell therapy for hematologic malignancies
Authors: Tan Su Yin Elaine , Hu Yong Xian , Huang He 
Published: October 2022

AbstractChimeric antigen receptors (CAR) T‐cell therapy is one of the most effective treatments in curing hematologic malignancies. Besides the four CD19 CAR T‐cells therapy recently approved by the US Food and Drug Administration (FDA), CD20 CAR T‐cell therapy is now another effective treatment option for relapsed or refractory non‐Hodgkin lymphoma (NHL). CD20 CAR T‐cell infusion has achieved remarkable clinical outcomes in patients with B‐cell malignancies. This review will cover the current situations, advantages, limitations, prospects, and application of CD20 CAR T‐cell therapy.
A comprehensive study of p53 protein
Authors: Patil Manisha R. , Bihari Anand 
Published: October 2022

AbstractThe protein p53 has been extensively investigated since it was found 43 years ago and has become a “guardian of the genome” that regulates the division of cells by preventing the growth of cells and dividing them, that is, inhibits the development of tumors. Initial proof of protein existence by researchers in the mid‐1970s was found by altering and regulating the SV40 big T antigen termed the A protein. Researchers demonstrated how viruses play a role in cancer by employing viruses' ability to create T‐antigens complex with viral tumors, which was discovered in 1979 following a viral analysis and cancer analog research. Researchers later in the year 1989 explained that in Murine Friend, a virus‐caused erythroleukemia, commonly found that p53 was inactivated to suggest that p53 could be a “tumor suppressor gene.” The TP53 gene, encoding p53, is one of human cancer's most frequently altered genes. The protein‐regulated biological functions of all p53s include cell cycles, apoptosis, senescence, metabolism of the DNA, angiogenesis, cell differentiation, and immunological response. We tried to unfold the history of the p53 protein, which was discovered long back in 1979, that is, 43 years of research on p53, and how p53's function has been developed through time in this article.
Achievements and perspectives of synthetic biology in botanical insecticides
Authors: Wang Shengli , Zhan Chuanling , Chen Ruiqi , Li Weiguo , Song Hongjian , Zhao Guangrong , Wen Mingzhang , Liang Dongmei , Qiao Jianjun 
Published: October 2022

AbstractBotanical insecticides are the origin of all insecticidal compounds. They have been widely used to control pests in crops for a long time. Currently, the commercial production of botanical insecticides extracted from plants is limited because of insufficient raw material supply. Synthetic biology is a promising and effective approach for addressing the current problems of the production of botanical insecticides. It is an emerging biological research hotspot in the field of botanical insecticides. However, the biosynthetic pathways of many botanical insecticides are not completely elucidated. On the other hand, the cytotoxicity of botanical pesticides and low efficiency of these biosynthetic enzymes in new hosts make it still challenging for their heterologous production. In the present review, we summarized the recent developments in the heterologous production of botanical insecticides, analyzed the current challenges, and discussed the feasible production strategies, focusing on elucidating biosynthetic pathways, enzyme engineering, host engineering, and cytotoxicity engineering. Looking to the future, synthetic biology promises to further advance heterologous production of more botanical pesticides.
Microbial volatile organic compounds 2‐heptanol and acetoin control Fusarium crown and root rot of tomato
Authors: Du Jianfeng , Ji Yatai , Li Yue , Liu Baoyou , Yu Yiming , Chen Dayin , Li Zhiwei , Zhao Tianfeng , Xu Xinning , Chang Qingle , Li Zimeng , Li Pengan , Jiang Yanke , Chen Yudong , Lu Chongchong , Wei Lansu , Wang Cunchen , Li Yang , Yin Ziyi , Kong Lingguang , Ding Xinhua 
Published: October 2022

AbstractSome microbial volatile organic compounds (mVOCs) can act as antagonistic weapons against plant pathogens, but little information is available on the contribution of individual mVOC to biocontrol and how they interact with plant pathogens. In this study, the Bacillus subtilis strain N‐18 isolated from the rhizosphere of healthy plants grown in areas where Fusarium crown and root rot (FCRR) of tomato occurs could reduce the 30% of the incidence of FCRR. Moreover, the volatile organic compounds (VOCs) produced by N‐18 had inhibitory effects on Fusarium oxysporum f. sp. radicis‐lycopersici (FORL). The identification of VOCs of N‐18 was analyzed by the solid‐phase microextraction coupled to gas chromatography‐mass spectrometry. Meanwhile, we conducted sensitivity tests with these potential active ingredients and found that the volatile substances acetoin and 2‐heptanol can reduce the 41.33% and 35% of the incidence of FCRR in tomato plants. In addition, the potential target protein of acetoin, found in the cheminformatics and bioinformatics database, was F. oxysporum of hypothetical protein AU210_012600 (FUSOX). Molecular docking results further predicted that acetoin interacts with FUSOX protein. These results reveal the VOCs of N‐18 and their active ingredients in response to FORL and provide a basis for further research on regulating and controlling FCRR.
Miro1 regulates mitochondrial homeostasis and meiotic resumption of mouse oocyte
Authors: Xue Yue , Meng Tie‐Gang , Ouyang Ying‐Chun , Liu Sai‐Li , Guo Jia‐Ni , Wang Zhen‐Bo , Schatten Heide , Song Chun‐Ying , Guo Xing‐Ping , Sun Qing‐Yuan 
Published: October 2022

AbstractMiro1, a mitochondrial Rho GTPase1, is a kind of mitochondrial outer membrane protein involved in the regulation of mitochondrial anterograde transport and its subcellular distribution. Mitochondria influence reproductive processes of mammals in some aspects. Mitochondria are important for oocyte maturation, fertilization and embryonic development. The purpose of this study was to evaluate whether Miro1 regulates mouse oocyte maturation by altering mitochondrial homeostasis. We showed that Miro1 was expressed in mouse oocyte at different maturation stages. Miro1 mainly distributed in the cytoplasm and around the spindle during oocyte maturation. Small interference RNA‐mediated Miro1 depletion caused significantly abnormal distribution of mitochondria and endoplasmic reticulum as well as mitochondrial dysfunction, resulting in severely impaired germinal vesicle breakdown (GVBD) of mouse oocytes. For those oocytes which went through GVBD in the Miro1‐depleted group, part of them were inhibited in meiotic prophase I stage with abnormal chromosome arrangement and scattered spindle length. Our results suggest that Miro1 is essential for maintaining the maturation potential of mouse oocyte.
Mitochondria and vascular calcification in chronic kidney disease: Lessons learned from the past to improve future therapy
Authors: Pongsuwan Karn , Kusirisin Prit , Narongkiattikhun Phoom , Chattipakorn Siriporn C. , Chattipakorn Nipon 
Published: October 2022

AbstractChronic kidney disease–mineral and bone disorders (CKD‐MBD) is a common complication of CKD Stages 3–5. Hyperphosphatemia is one of the major metabolic components of CKD‐MBD, frequently resulting in vascular calcification (VC) in advanced‐stage patients. Also, a long duration of renal replacement therapy can cause the worsening of VC, leading to increased cardiovascular morbidity and mortality. Vascular smooth muscle cells play an important role in the development of VC through osteochondrogenic transformation and the apoptotic process. It has been shown that mitochondrial dysfunction is involved with CKD progression, and excessive oxidative stress can aggravate osteoblastic transformation and VC. Currently, novel interventions targeting mitochondrial function and dynamics, in addition to mitochondrial antioxidants, have been studied with the aim of attenuating VC. This review aims to comprehensively summarize and discuss the experimental and clinical reports concerning mitochondrial studies, along with the purpose of interventions that can improve the outcomes of VC among CKD patients.