bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circ_0027885 sponges miR‐203‐3p to regulate RUNX2 expression and alleviates osteoporosis progression
Authors: Fang Shuhua , Cao Dingwen , Wu Zhanpo , Chen Jie , Huang Yafei , Shen Ying , Gao Zengxin 
Published: November 2022

Abstract
Background
Osteoporosis (OP) is a progressive metabolic disorder that is difficult to cure clinically. The molecular mechanisms of OP are urgently needed to be further examined. This study was designed to explore the potential function of circ_0027885 during osteogenic differentiation, as well as the systematical interactions among circ_0027885, miR-203-3p and runt-related transcription factor 2 (RUNX2).
Methods
Relative levels of circ_0027885, miR-203-3p and RUNX2 were analyzed with RT-qPCR and western blotting. Alizarin red staining was performed to detect the mineralization ability under the control of circ_0027885 and miR-203-3p. Dual-luciferase reporter gene assay was conducted to examine the combination among circ_0027885, miR-203-3p and RUNX2.
Results
Our research exhibited that circ_0027885 was significantly increased during hBMSCs differentiation. Overexpression of circ_0027885 notably facilitated osteogenic differentiation and upregulated RUNX2 expression, while knockdown of circ_0027885 reversed the above results. Through prediction on bioinformatics analysis, miR-203-3p was the target binding circ_0027885, and RUNX2 was the potential target of miR-203-3p. Subsequently, these changes induced by the overexpression of circ_0027885 were reversed upon addition of miR-203-3p mimic.
Conclusions
Circ_0027885 could sponge miR-203-3p to regulate RUNX2 expression and alleviate osteoporosis progression.
Dielectric Lined Waveguides for Low Loss Millimeter Wave and Terahertz Transmission
Authors: Thackston Kyle , Doane John , Anderson James , Chrayteh Mhamad , Hindle Francis 
Published: November 2022

Abstract
By coating the inside of an overmoded, smooth wall metallic waveguide with a thin dielectric layer, one can obtain similar boundary conditions to corrugated waveguides and achieve extremely low transmission loss propagating the HE11 mode. As presented here, dielectric lined waveguides are a cost-effective alternative to corrugated waveguides for broadband microwave transmission, particularly at frequencies above 300 GHz. A theoretical model provides an analytic method for computing attenuation. The propagation mode of a prototype dielectric lined waveguide is characterized using low power transmission measurements to analyze the beam radiated from the waveguide aperture. Results indicate HE11 mode purity of approximately 98%. Furthermore, we quantified attenuation with low power Fabry-Perot measurements, verifying low loss performance of the experimental prototype. These results demonstrate that dielectric lined waveguides could have applications in many fields demanding low attenuation millimeter and terahertz transmission, such as radar, high-frequency communication systems, THz dynamic nuclear polarization, and electron cyclotron heating in magnetically confined fusion experiments.
The MOORA method integrated finite element analysis of thin-wall tube structures for energy absorption in the front bumper
Authors: Yurdakul Mustafa , Ülke İbrahim , Sağol Bekir Batuhan , İç Yusuf Tansel 
Published: November 2022

Abstract
The developing world economy and the increasing income level cause the number of vehicles on the highways to increase rapidly. The increasing number of vehicles makes the highways more unsafe and increases the probability of accidents. This study is concerned with the dynamic analysis of axial and oblique compression in thin-walled tubes. Tubes under the effect of axial and oblique compression were compared with different cross-section profiles in terms of performance. Collision energy absorbed, crushing force efficiency, peak force, and velocity graphs are discussed in these performance parameters. The collision of the plates is discussed considering the speed and mass parameters that have entered the tubes using different cross-sections. Also, we developed a MOORA model integrated finite element analysis to rank the different alternative structures for different simulation cases. The MOORA model’s ranking results presented the most suitable cross-section profiles that will provide the most appropriate damping result.
PARP-dependent acetylation of N4-cytidine in RNA appears in UV- damaged chromatin
Authors: Kovaříková Alena Svobodová , Stixová Lenka , Kovařík Aleš , Bártová Eva 
Published: November 2022

Abstract
RNA modifications have been known for many years, but their function has not been fully elucidated yet. For instance, the regulatory role of acetylation on N4-cytidine (ac4C) in RNA should be explored not only from the view of regulation of RNA stability and mRNA translation but also during DNA repair. Here, we observe a pronounced positivity of ac4C RNA at DNA lesions of interphase cells and in irradiated cells in telophase. Ac4C RNA appears in the damaged genome from 2 to 45 minutes after microirradiation. However, RNA cytidine acetyltransferase NAT10 did not accumulate to damaged chromatin. This process was not dependent on the G1, S, and G2 cell cycle phases. Also, we observed that the PARP inhibitor, olaparib, prevents the recruitment of ac4C RNA to DNA lesions. Together, our data imply that acetylation of N4-cytidine in RNA is an important RNA modification that, with a high probability, mediates DNA damage repair. Ac4C RNA likely causes de-condensation of chromatin in the vicinity of DNA lesions accessible for other DNA repair factors playing a role in DNA damage response. Alternatively, RNA modifications, including ac4C, could be markers of damaged RNAs.
The influence of minor aortic branches in Type-B Aortic Dissection: patient-specific flow simulations informed by 4D-Flow MRI
Authors: Stokes Catriona , Haupt Fabian , Becker Daniel , Muthurangu Vivek , von Tengg-Kobligk Hendrik , Balabani Stavroula , Díaz-Zuccarini Vanessa 
Published: November 2022

Abstract
Type-B Aortic Dissection (TBAD) is a disease in which a tear develops in the intimal layer of the descending aorta forming a true lumen (TL) and false lumen (FL). Because disease outcomes are thought to be influenced by haemodynamic quantities such as pressure and Wall Shear Stress (WSS), their analysis via numerical simulations may provide valuable clinical insights. Major aortic branches are routinely included in simulations but minor branches are virtually always neglected, despite being implicated in TBAD progression and the development of complications. As minor branches are estimated to carry about 7-21% of cardiac output, neglecting them may affect simulation accuracy. We present the first simulation of TBAD with all pairs of intercostal, subcostal and lumbar arteries, using 4D-Flow MRI (4DMR) to inform patient-specific boundary conditions. Compared to an identical case without these branches, their inclusion improved agreement with 4DMR velocities, reduced Time-Averaged WSS (TAWSS) by up to 58\% and elevated oscillatory shear in regions where FL dilatation and calcification are observed in-vivo. Transmural pressure (TMP) was up to 61\% lower when minor branches were included. These effects indicate a need to account for minor branch flow loss if accuracy in clinically-relevant metrics is sought.
Management of nipple adenomas during pregnancy: case report and review of the literature
Authors: Combi Francesca , Palma Enza , Montorsi Giulia , Gambini Anna , Segattini Silvia , Papi Simona , Andreotti Alessia , Tazzioli Giovanni 
Published: November 2022

Abstract
Background: Nipple Adenoma is a very uncommon, benign neoplasm that involves the nipple. Generally, complete surgical excision of the nipple is the main treatment, alternative therapeutic methods such as Mohs micrographic surgery, nipple splitting enucleation, and cryotherapy can be considered. Benign disorders of the breast generally occur in the breast of young women. Even if the management during pregnancy is usually conservative and surgical excision is reserved for very strong malignancy suspicion, benign lesions can cause the impossibility to breastfeed after giving birth when involving the nipple.
Case Presentation: Here, we report a case of a 28-year-old woman with a 12-month history of progressive enlargement of the left nipple associated with erythema and intermittent serous-haematic discharge. The diagnostic assessment came out in favor of a nipple adenoma. After surgical treatment was recommended, the patient got pregnant. Surgical excision of nipple adenoma without complete resection of the nipple was performed after her first trimester of pregnancy under local anesthesia. A histopathological examination confirmed the diagnosis. No recurrence occurred after 12 months. The patient gave birth, had no deficit in lactation, and successfully breastfed.
Conclusions: Therefore, we consider that nipple adenoma enucleation might be a safe treatment even during pregnancy. Moreover, conservative local treatment of nipple adenomas can preserve the nipple aesthetically and functionally, thus allowing regular lactation and breastfeeding in young women.
Who pays?---Reorganizing tax burden based on purchasing power
Authors: Tominaga Kazuto 
Published: November 2022

Abstract
It is generally believed that a tax levied on sellers of some commodity is at least partly paid by buyers if its price rises. Based on the formal treatment of purchasing power, this paper demonstrates that such "shifting of tax burden'' does not occur in principle. Thus indirect taxes that assume such shifting are no different from direct ones in respect of tax payment: sellers pay the whole tax, and buyers only suffer a diminution in the value of their monetary assets by the price rise. We show a possible cause of the misconception is cognitive biases, including money illusions. We also examine how tax payment and economic incidence differ, and show that economic incidence, the widely accepted measure of changes in welfare, cannot be a yardstick for evaluating ``who pays the tax" at the same time. We discuss some other types of taxes that are remitted to the government by those who are different from ones supposed to pay the taxes, such as withholding income taxes, and show that they are paid as intended (i.e., paid by employees in the case of withholding taxes) owing to the explicit designation of taxpayers by law, in contrast to "indirect" taxes.
JEL Classification: H20 , H22 , K34
A pyrenoid-localized protein SAGA1 is necessary for Ca 2+ -binding protein CAS-dependent expression of nuclear genes encoding inorganic carbon transporters in Chlamydomonas reinhardtii
Authors: Shimamura Daisuke , Yamano Takashi , Niikawa Yuki , Donghui Hu , Fukuzawa Hideya 
Published: November 2022

Abstract
Microalgae induce a CO2-concentrating mechanism (CCM) to maintain photosynthetic affinity for dissolved inorganic carbon (Ci) under CO2-limiting conditions. In the model alga Chlamydomonas reinhardtii, the pyrenoid-localized Ca2+-binding protein CAS is required to express genes encoding the Ci transporters, high-light activated 3 (HLA3) and low-CO2-inducible protein A (LCIA). To identify new factors related to the regulation or components of the CCM, we isolated CO2-requiring mutants KO-60 and KO-62. These mutants had insertions of a hygromycin-resistant cartridge in the StArch Granules Abnormal 1 (SAGA1) gene, which is necessary to maintain the number of pyrenoids and the structure of pyrenoid tubules in the chloroplast. In both KO-60 and the previously identified saga1 mutant, expression levels of 532 genes were significantly reduced. Among them, 10 CAS-dependent genes, including HLA3 and LCIA, were not expressed in the saga1 mutants. While CAS was expressed normally at the protein levels, the localization of CAS was dispersed through the chloroplast rather than in the pyrenoid, even under CO2-limiting conditions. These results suggest that SAGA1 is necessary not only for maintenance of the pyrenoid structure but also for regulation of the nuclear genes encoding Ci transporters through CAS-dependent retrograde signaling under CO2-limiting stress.
Application of Optical Coherence Tomography Angiography for hydroxychloroquine-induced microvascular changes: a systematic review and meta-analysis
Authors: Ferreira André , Anjos Rita , José-Vieira Rafael , Afonso Miguel , Abreu Ana Carolina , Monteiro Sílvia , Macedo Mafalda , Andrade José P. , Furtado Maria João , Lume Miguel 
Published: November 2022

Abstract
Background

Retinal toxicity with long-term hydroxychloroquine (HCQ) treatment is a major concern. This systematic review aims to assess the application of Optical Coherence Tomography Angiography (OCTA) to detect HCQ-induced microvascular alterations.

Methods

PubMed, Scopus, Web of Science, and Cochrane Library databases were systematically searched until November 1st, 2021. Studies using OCTA as a primary diagnostic method to evaluate the macular microvasculature of HCQ users were included. Primary outcomes were macular vessel density (VD) and foveal avascular zone (FAZ) at the superficial (SCP) and deep (DCP) capillary plexus. Meta-analysis was performed using a random-effects model.

Results

Of 159 screened abstracts, seven were found eligible, enrolling 424 eyes from 335 patients. High-risk patients due to longer duration of treatment presented lower VD in the retinal microvasculature than those with low-risk in SCP (P = 0.01 in fovea; P = 0.002 in parafovea) and in DCP (P = 0.03 in fovea). When compared with healthy controls, HCQ users had lower VD in both plexus and a wider FAZ area – no quantitative synthesis was presented.

Conclusions

Microvascular changes were found in autoimmune patients under HCQ treatment without any documented retinopathy. However, the evidence produced so far does not allow to draw conclusion concerning the effect of drug as studies were not controlled for disease duration.
Low-Level Light Therapy Effect on Resting-State Connectivity in Patients Following Moderate Traumatic Brain Injury
Authors: Chan Suk-tak , Mercaldo Nathaniel , Longo Maria Gabriela Figueiro , Welt Jonathan , Avesta Arman , Namati Jacqueline , Lee Jarone , Lev Michael , Ratai Eva-Maria , Wenke Michael , Parry Blair , Drake Lynn , Anderson Richard , Rauch Terry , Diaz-Arrastia Ramon , Kwong Kenneth , Hamblin Michael , Vakoc Benjamin , Gupta Rajiv 
Published: November 2022

Abstract
Recent studies demonstrate that low-level light therapy (LLLT) modulates recovery in patients with traumatic brain injury (TBI). However, the impact of LLLT on brain activity following TBI has not been well described. Here we use a randomized, double-blind, placebo-controlled design to investigate the effect of LLLT on resting-state connectivity at acute (within 1-week), subacute (2–3 weeks), and late-subacute (3-month) time-points following moderate TBI. A characteristic connectivity profile was observed during TBI recovery in both sham- (n = 21) and LLLT-treated patients (n = 17) compared to healthy controls, with increased resting-state connectivity between frontal and parietal cortices. Temporal comparisons between LLLT- and sham-treated patients showed that the acute-to-subacute changes in resting-state connectivity were significantly greater in LLLT-treated patients. These results demonstrate that LLLT increased resting-state connectivity in the presence of a regional hyperconnectivity response to moderate TBI, suggesting that LLLT can modulate activity in the injured brain and encouraging its further exploration as a therapy for TBI.
WITHDRAWN: Pattern Having Two Equal Maximum Intensities Near Double Slit
Authors: peng hui 
Published: November 2022

Abstract

The standard interpretation of Young’s double slit experiment is that the light behaves as waves before and after passing through the diaphragm of the double slit. There is one primary maximum intensity at the central position of the interference pattern. Recently, the photon chamber has been proposed and utilized to study the behavior of photons near the detecting screen. The experiments show that the light, near the screen, behaves as photons propagating along the straight-line trajectories that distribute as waves. In this article, we place the photon chamber near the diaphragm of the double slit.
The Experiments show: (1) at approximate up to 150 mm range from the diaphragm, there are two primary maximum intensities (Figure on the left), which violates the standard wave interpretations (Figure on the right); (2) the light beams behave as photons.
Unparalleled Sarcasm: A Framework of Parallel Deep LSTMs with Cross Activation Functions Towards Detection and Generation of Sarcastic Statements
Authors: Das Sourav , Ghosh Soumitra , Kolya Anup Kumar , Ekbal Asif 
Published: November 2022

Abstract
Sarcasm is a delicate form of expressing any opinions in a facetious way. The advent of communication using social networks has mass-produced the new avenues of socialization. It can be further said that humor, irony, sarcasm, and wit are the four chariots of being socially funny in the modern day. Among these, sarcasm is a sophisticated way of wrapping any immanent truth, message, or even mockery within a hilarious manner. In the present work, we manually extract the features of a benchmark pop culture sarcasm corpus containing sarcastic dialogues and monologues, to generate padding sequences from the matrices formed of the vector representations. We further propose an amalgamation of four Parallel deep Long Short Term Networks (pLSTM), each with a distinctive activation classifier. These modules are primarily aimed for successfully detecting the sarcasm from the text corpus through the training phase. Not limited to only that, besides generic validation testing, we also mimic the human-alike statement successions initiating from random user input seed words to produce auto-generated sarcastic dialogues, which have semantic significance in an understandable sense. Our proposed model for detecting sarcasm peaks with a training accuracy of 98.95% when trained with the discussed dataset. Consecutively it achieves 98.31% accuracy among the test cases on open source humor English literature. Our approach transcends several previous state-of-the-art works and results in sophisticated sarcastic statement generation. We also culture the probable prospects for producing even better refined automated sarcasm generation.
УЧЕБНИК ЯНА АМОСА КОМЕНСКОГО«ПРЕДДВЕРИЕ» (VESTIBULUM)
Authors: В.В. Рыбаков , И.В. Кувшинская 
Published: November 2022

Публикация представляет собой первый перевод на русский язык краткой редакции учебника Яна Амоса Коменского Vestibulum («Преддверие»), созданного как введение к учебнику Janua Lnguarum («Дверь Языков») и в окончательном виде напечатанного в первом томе собрания его сочинений (Амстердам, 1657–1658). Постепенная демонстрация грамматических явлений латинского языка дается в книге как описание предметов и явлений окружающего мира, которое можно рассматривать как краткую энциклопедию, содержащую основные слова и понятия, необходимые на первом этапе обучения латыни.
This is the first translation into Russian of shorter version of Johan Amos Comenius's textbook “Vestibulum”, which was planned as an introduction to the textbook “Janua Linguarum” (“The Door to Languages") and finally printed in the first volume of his collected works (Amsterdam, 1657–1658). A gradual demonstration of Latin grammar is given in the book on the basis of objects and phenomena of the surrounding world, which can be regarded as a brief encyclopedia containing the basic words and concepts needed in the first stage of Latin teaching.
«ФИЗИКА» Я.А. КОМЕНСКОГОКАК ПАНСОФИЧЕСКОЕ СОЧИНЕНИЕ:(ПРЕДИСЛОВИЕ К ПЕРЕВОДУ)
Authors: С.М. Марчукова 
Published: November 2022

Статья, предваряющая перевод учебника Я.А. Коменского «Физика» (переводчик — А.И. Золотухина) посвящена выявлению троичности и многомерности в его тексте. В ней показано, как эти пансофические начала в контексте метафизической традиции параллельного чтения учебника и Священного Писания формируют метод, который позволяет выстроить на едином фундаменте порядок познания вещей в материальном и духовном мире, объединить знания о Боге, природе и человеке в целостную систему.
The prolusion to the translation of J.A. Comenius's “Physics” (trans. by A. Zolotukhina) reveals the triplicity and multidimensionality in this text. It is showed, how in the context of parallel reading of the primer and the Sacred Scripture the pansophic principles form a method, that helps to set out the unified order of cognition of things in material, as well as in spiritual world; and to put knowledge about God, nature and man together in a harmonic system.
ДОБЛЕСТЬ КАТОЛИКАСЭР ТОМАС ЭРЕНДЕЛЛ ИОСАДА ЭСТЕРГОМА (1595 г.)
Authors: А.Ю. Серегина 
Published: November 2022

В пост-реформационной Англии католическое дворянство оказалось пораженным в гражданских правах и не было в состоянии подтверждать свой гендерный и социальный статус обычным образом, через военную и государственную службу. Дворянам пришлось изобретать новые социальные стратегии, одной из которых стало участие в военных кампаниях против турок, воспринимавшихся как общее дело христиан. Cозданный Эренделлом в его автобиографическом послании образ христианского рыцаря стал важной частью католической идентич-ности его семьи, а завязанные во время Венгерской кампании контакты помогли сформироваться связям патроната между английскими католиками-эмигрантами и венгерскими аристократами.
In the post-Reformation England, Catholic gentry lost its civic rights and could not confirm its gender and social status in a usual way, through military and civil service. Catholic gentlemen had to invent new social strategies, and one of these was participation in military campaigns against the Turks, which were viewed as the common cause for all Christians. It is argued in the introductory article that the image of a Christian knight created by Arundell was an important part of his descendants’ Catholic identity, and contacts made by him during the Hungarian campaign helped create the ties of patronage between the English Catholic emigres, and Hungarian aristocrats.