bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preserving the past or past preserving: sustaining the legacy of postmodern museum architecture
Authors: Armstrong Paul J. , Kapp Paul H. 
Published: May 2022

AbstractThe publication of Complexity and Contradiction in Architecture in 1964 signaled the end of Modernism. The reality was that the modern movement had already jettisoned its ideological underpinnings and had become merely another ‘style.’ The avant garde architects in Europe and in North America were ready to move on and saw Postmodernism as a liberating antidote to the strictures of high Modernism. Historic architectural styles, which had been vilified as antiquated and out of step with modern culture, were revived, reinterpreted, and manipulated. However, Postmodernism, which had burned brightly during the 1970s and 1980s, was superseded by other architectural movements, namely, Deconstructivism, Pluralism, during the waning years of the 12th century.Even though new building forms and design theory changed during Postmodernism, building technology remained the same. Exterior walls continued to be built as skins, comprised of either glass, masonry, metal, or synthetic cladding, which were hung of steel or concrete framing. Rubberised membranes covered essentially flat roofs. Moisture infiltration was managed in ever complex composite wall assemblies. More important, environmental systems decoupled nature from interiors and were designed to manage ever demanding humidity control requirements. Through the development of new building technology, Modernism severed design style from traditional construction. In re-introducing historical forms back into architecture, Postmodernism complicated constructability. Moreover, Postmodernism and its successors rarely developed new technological ideas by introducing more intricate building forms, which were based on theoretical ideas rather than technical ones, while continuing to employ Modernism building technology into their buildings. This inherent paradox is the most consequential challenge in preserving Postmodernism. Today, approximately 40 years after its inception, we must consider if, in some cases. is it tenable to preserve Postmodern buildings?This paper reassesses three museums of the Postmodern era through the twin lenses of historic preservation and their legacy as cultural artifacts. It analyses how three iconic Postmodern museums, the Wexner Centre for the Arts in the USA, the Neue Staatsgalerie in Germany, and the Hedmark Museum in Norway, became cultural artifacts and how each of them present technical challenges for their future preservation. These museums represent late 20th century theoretical ideas, which were more a melding of pluralistic influences than design ideology, and the utilisation of Modernist technology. All of which present unique conditions for conservation.
Exploration of mood spectrum symptoms during a major depressive episode: The impact of contrapolarity—Results from a transdiagnostic cluster analysis on an Italian sample of unipolar and bipolar patients
Authors: Mineo Ludovico , Rodolico Alessandro , Spedicato Giorgio Alfredo , Aguglia Andrea , Bolognesi Simone , Concerto Carmen , Cuomo Alessandro , Goracci Arianna , Maina Giuseppe , Fagiolini Andrea , Amore Mario , Aguglia Eugenio 
Published: May 2022

AbstractBackgroundSubthreshold hypomania during a major depressive episode challenges the bipolar-unipolar dichotomy. In our study we employed a cross-diagnostic cluster analysis - to identify distinct subgroups within a cohort of depressed patients.MethodsA k-means cluster analysis— based on the domain scores of the Mood Spectrum Self-Report (MOODS-SR) questionnaire—was performed on a data set of 300 adults with either bipolar or unipolar depression. After identifying groups, between-clusters comparisons were conducted on MOODS-SR domains and factors and on a set of sociodemographic, clinical and psychometric variables.ResultsThree clusters were identified: one with intermediate depressive and poor manic symptomatology (Mild), one with severe depressive and poor manic symptomatology (Moderate), and a third one with severe depressive and intermediate manic symptomatology (Mixed). Across the clusters, bipolar patients were significantly less represented in the Mild one, while the DSM-5 “Mixed features” specifier did not differentiate the groups. When compared to the other patients, those of Mixed cluster exhibited a stronger association with most of the illness-severity, quality of life, and outcomes measures considered. After performing pairwise comparisons significant differences between “Mixed” and “Moderate” clusters were restricted to: current and disease-onset age, psychotic ideation, suicidal attempts, hospitalization numbers, impulsivity levels and comorbidity for Cluster B personality disorder.ConclusionsIn the present study, a clustering approach based on a spectrum exploration of mood symptomatology led to the identification of three transdiagnostic groups of patients. Consistent with our hypothesis, the magnitude of subthreshold (hypo)manic symptoms was related to a greater clinical severity, regardless of the main categorical diagnosis.
Inactivation of AR or ERα in Extrahypothalamic Neurons Does not Affect Osteogenic Response to Loading in Male Mice
Authors: Kim Na Ri , David Karel , Sommers Vera , Schollaert Dieter , Deboel Ludo , Ohlsson Claes , Gustafsson Jan-Åke , Antonio Leen , Decallonne Brigitte , Claessens Frank , Vanderschueren Dirk , Dubois Vanessa 
Published: May 2022

Abstract
Failure of bone mass maintenance in spite of functional loading is an important contributor to osteoporosis and related fractures. While the link between sex steroids and the osteogenic response to loading is well established, the underlying mechanisms are unknown, hampering clinical relevance. Androgens inhibit mechanoresponsiveness in male mice, but the cell type mediating this effect remains unidentified. To evaluate the role of neuronal sex steroid receptor signaling in the male bone’s adaptive capacity, we subjected adult male mice with an extrahypothalamic neuron-specific knockout of the androgen receptor (N-ARKO) or the estrogen receptor alpha (N-ERαKO) to in vivo mechanical stimulation of the tibia. Loading increased cortical thickness in the control animals mainly through periosteal expansion, as total cross-sectional tissue area and cortical bone area but not medullary area were higher in the loaded than the unloaded tibia. Trabecular bone volume fraction also increased upon loading in the control group, mostly due to trabecular thickening. N-ARKO and N-ERαKO males displayed a loading response at both the cortical and trabecular bone compartments that was not different from their control littermates. In conclusion, we show that the presence of androgen receptor or estrogen receptor alpha in extrahypothalamic neurons is dispensable for the osteogenic response to mechanical loading in male mice.
Brown Adipose Tissue—A Translational Perspective
Authors: Carpentier André C , Blondin Denis P , Haman François , Richard Denis 
Published: May 2022

AbstractBrown adipose tissue (BAT) displays the unique capacity to generate heat through uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for cardiometabolic diseases. Here, we review BAT cellular metabolism, its regulation by the central nervous and endocrine systems and circulating metabolites, the plausible roles of this tissue in human thermoregulation, energy balance, and cardiometabolic disorders, and the current knowledge on its pharmacological stimulation in humans. The current definition and measurement of BAT in human studies relies almost exclusively on BAT glucose uptake from positron emission tomography with 18F-fluorodeoxiglucose, which can be dissociated from BAT thermogenic activity, as for example in insulin-resistant states. The most important energy substrate for BAT thermogenesis is its intracellular fatty acid content mobilized from sympathetic stimulation of intracellular triglyceride lipolysis. This lipolytic BAT response is intertwined with that of white adipose (WAT) and other metabolic tissues, and cannot be independently stimulated with the drugs tested thus far. BAT is an interesting and biologically plausible target that has yet to be fully and selectively activated to increase the body’s thermogenic response and shift energy balance. The field of human BAT research is in need of methods able to directly, specifically, and reliably measure BAT thermogenic capacity while also tracking the related thermogenic responses in WAT and other tissues. Until this is achieved, uncertainty will remain about the role played by this fascinating tissue in human cardiometabolic diseases.
A Case of a Pregnant Woman With Primary Aldosteronism and Superimposed Preeclampsia Treated With Esaxerenone
Authors: Yamashita Kaoru , Morimoto Satoshi , Inoue Yuko , Hirata Kiyotaka , Kimura Shihori , Seki Yasufumi , Bokuda Kanako , Watanabe Daisuke , Ichihara Atsuhiro 
Published: May 2022

Abstract
During pregnancy, there is no established treatment for idiopathic hyperaldosteronism (IHA), the most common form of primary aldosteronism due to bilateral adrenal hyperplasia. Here, we report the case of a pregnant patient with IHA who was successfully treated with esaxerenone, a nonsteroidal mineralocorticoid receptor (MR) antagonist. A 39-year-old woman was diagnosed with IHA and commenced on nifedipine 20 mg daily because she desired to be pregnant. After 1 year, she became pregnant. Her blood pressure was well controlled until 34 weeks of gestation when her home blood pressure became elevated up to 140/90 mmHg. Although the dose of nifedipine was increased to 80 mg daily, her blood pressure increased to 151/97 mmHg, and urinary test showed proteinuria of 2+ in 35 weeks of gestation. She was diagnosed with superimposed preeclampsia (SPE) and additionally treated with esaxerenone. Her blood pressure decreased to 120-140/98-100 mmHg and the proteinuria improved to ±. A successful cesarean section at 37 weeks resulted in the delivery of a healthy baby boy. Her blood pressure was well controlled although esaxerenone was discontinued 2 weeks after the delivery. This is the first case of a pregnant woman who was safely treated with esaxerenone despite being a female at advanced maternal age who had been diagnosed with IHA and developed SPE. Further studies are needed to investigate the efficacy and safety of nonsteroidal selective MR antagonist in similar pregnant patients with IHA to establish better treatment strategy for these patients.
Single-stage repair of displaced bucket-handle meniscal tears with anterior cruciate ligament reconstruction leads to good meniscal survivorship
Authors: Robinson James R. , Bruce David , Davies Hywel , Porteous Andrew J. , Murray James R. D. , Howells Nick R. 
Published: May 2022

Aims The best surgical strategy for the management of displaced bucket-handle (BH) meniscal tears in an anterior cruciate ligament (ACL)-deficient knee is unclear. Combining meniscal repair with ACL reconstruction (ACLR) is thought to improve meniscal healing rates; however, patients with displaced BH meniscal tears may lack extension. This leads some to advocate staged surgery to avoid postoperative stiffness and loss of range of motion (ROM) following ACLR. Methods We reviewed the data for a consecutive series of 88 patients (mean age 27.1 years (15 to 49); 65 male (74%) and 23 female (26%)) who underwent single-stage repair of a displaced BH meniscal tear (67 medial (76%) and 21 lateral (24%)) with concomitant hamstring autograft ACLR. The patient-reported outcome measures (PROMs) EuroQol visual analogue scale (EQ-VAS), EuroQol five-dimension health questionnaire (EQ-5D), Knee injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee score (IKDC), and Tegner score were recorded at final follow-up. A Kaplan-Meier survival analysis was performed to estimate meniscal repair survivorship. Analyses were performed with different cut-offs for meniscal and ACL injury-to-surgery time (within three weeks, three to ten weeks, and more than ten weeks). Results Meniscal repair survivorship at a median final follow-up of 55 months (interquartile range (IQR) 24 to 91) was 82% (95% confidence interval 70 to 89). A total of 13 meniscus repairs failed (12 requiring meniscectomy and one requiring a further meniscal repair). At final follow-up, median PROMs were: EQ-VAS 85 (IQR 75 to 90), EQ-5D Index 0.84 (IQR 0.74 to 1.00), KOOS Pain 89 (IQR 80 to 94), KOOS Symptoms 82 (IQR 71 to 93), KOOS Activities of Daily Living 97 (IQR 91 to 100), KOOS Sport and Recreation 80 (IQR 65 to 90), KOOS Quality of Life 69 (IQR 53 to 86), IKDC 82.8 (IQR 67.8 to 90.8), and Tegner 6 (IQR 4 to 7). Two patients underwent revision ACLR following further injuries. One patient had an arthroscopic washout for infection at 11 days post-BH meniscal repair/ACLR. Four patients (4.5%) required a further procedure for stiffness, reduced ROM, and pain, and all were operated on within three weeks of meniscal injury. There was no difference in the interval between meniscal injury and surgery between repairs that failed and those that survived. Conclusion These data suggest that concomitant ACLR with repair of displaced BH meniscal tears, even if they have been displaced for some time, appears to afford satisfactory PROMs and good survivorship. Repairs within three weeks of meniscal injury may be associated with higher rates of postoperative reintervention for stiffness. Cite this article: Bone Joint J 2022;104-B(6):680–686.
Virtual management of clinically suspected scaphoid fractures
Authors: Stirling Paul H. C. , Simpson Cameron J. , Ring David , Duckworth Andrew D. , McEachan Jane E. 
Published: May 2022

Aims The aim of this study was to describe the introduction of a virtual pathway for the management of patients with a suspected fracture of the scaphoid, and to report patient-reported outcome measures (PROMs) and satisfaction following treatment using this service. Methods All adult patients who presented with a clinically suspected scaphoid fracture that was not visible on radiographs at the time of presentation during a one-year period were eligible for inclusion in the pathway. Demographic details, findings on examination, and routine four-view radiographs at the time of presentation were collected. All radiographs were reviewed virtually by a single consultant hand surgeon, with patient-initiated follow-up on request. PROMs were assessed at a minimum of one year after presentation and included the abbreviated version of the Disabilities of the Arm, Shoulder and Hand Score (QuickDASH), the EuroQol five-dimension five-level health questionnaire (EQ-5D-5L), the Net Promoter Score (NPS), and return to work. Results A total of 221 patients were referred to the virtual pathway. Their mean age was 41 years (range 16 to 87) and there were 99 male patients (45%). A total of 189 patients (86%) were discharged with advice and 19 (9%) were recalled for clinical review: seven with an undisplaced scaphoid fracture, six with another fracture of the hand or wrist, two with a scapholunate ligament injury, and four in whom no abnormality was detected. A total of 13 patients (6%) initiated follow-up with the hand service: no fracture or ligament injury was identified in this group. PROMs were available for 179 patients (81%) at a mean follow-up of 19 months (range 13 to 33). The median QuickDASH score was 2.3 (interquartile range (IQR) 0 to 15.9), the median EQ-5D-5L was 0.85 (IQR 0.73 to 1.00), the NPS was 76, and 173 patients (97%) were satisfied with their treatment. There were no documented cases of symptomatic nonunion one year following injury. Conclusion We describe the introduction of a virtual pathway for the management of patients with a suspected scaphoid fracture. We found high levels of patient satisfaction, excellent PROMs, and no detrimental effects in the vast majority of cases. Cite this article: Bone Joint J 2022;104-B(6):709–714.
Elbow hemiarthroplasty with a 3D-printed megaprosthesis for defects of the distal humerus or proximal ulna after tumour resection
Authors: Liang Haijie , Yang Yi , Guo Wei , Yan Liang , Tang Xiaodong , Li Dasen , Qu Huayi , Zang Jie , Du Zhiye 
Published: May 2022

Aims The aim of this study was to investigate the feasibility of application of a 3D-printed megaprosthesis with hemiarthroplasty design for defects of the distal humerus or proximal ulna following tumour resection. Methods From June 2018 to January 2020, 13 patients with aggressive or malignant tumours involving the distal humerus (n = 8) or proximal ulna (n = 5) were treated by en bloc resection and reconstruction with a 3D-printed megaprosthesis with hemiarthroplasty, designed in our centre. In this paper, we summarize the baseline and operative data, oncological outcome, complication profiles, and functional status of these patients. Results Preparation of the prosthesis was a mean of 8.0 days (SD 1.5), during which time no patients experienced tumour progression. The mean operating time and intraoperative blood loss were 158.1 minutes (SD 67.6) and 176.9 ml (SD 187.8), respectively. All of the prostheses were implanted successfully. During a mean follow-up of 25.7 months (SD 7.8), no patients died, but four had complications (two superficial wound problems, one temporary palsy of radial nerve, and one dislocation). No aseptic loosening, structural failure, infection, heterotopic ossification, or degenerative arthritis was seen in this study. The mean flexion of the elbow was 119.6° (SD 15.9°) and the mean extension lag was 11.9° (SD 13.8°). The mean Musculoskeletal Tumor Society 93 score and Mayo Elbow Performance Score were 28.4 (SD 0.9) and 97.7 (SD 4.4), respectively. Conclusion The custom-made, 3D-printed megaprosthesis with hemiarthroplasty is a feasible option for functional reconstruction after resection of a tumour in the distal humerus or proximal ulna. Cite this article: Bone Joint J 2022;104-B(6):747–757.
Projections for primary hip and knee replacement surgery up to the year 2060: an analysis based on data from The National Joint Registry for England, Wales, Northern Ireland and the Isle of Man
Authors: Matharu GS , Culliford DJ , Blom AW , Judge A 
Published: May 2022

Introduction We estimated the number of primary total hip and knee replacements (THR and TKR) that will need to be performed up to the year 2060. Methods We used data from The National Joint Registry for England, Wales, Northern Ireland and the Isle of Man on the volume of primary THRs (n=94,936) and TKRs (n=100,547) performed in 2018. We projected future numbers of THR and TKR using a static estimated rate from 2018 applied to population growth forecast data from the UK Office for National Statistics up to 2060. Results By 2060, THR and TKR volume would increase from 2018 levels by an estimated 37.7% (n=130,766) and 36.6% (n=137,341), respectively. For both males and females demand for surgery was also higher for patients aged 70 and over, with older patients having the biggest relative increase in volume over time: 70–79 years (44.6% males, 41.2% females); 80–89 years (112.4% males, 85.6% females); 90 years and older (348.0% males, 198.2% females). Conclusion By 2060 demand for hip and knee joint replacement is estimated to increase by almost 40%. Demand will be greatest in older patients (70+ years), which will have significant implications for the health service requiring forward planning given that morbidity and resource use is higher in this population. These issues, coupled with two waves of COVID-19, will impact the ability of health services to deliver timely joint replacement to many patients for a number of years, requiring urgent planning.
Are multiple-use bottles of chlorhexidine solutions at risk of contamination in joint replacement surgery?
Authors: Aquilina CO , Aquilina AL , Webb J , Albur M , Whitehouse MR 
Published: May 2022

Introduction Chlorhexidine gluconate 2% w/v in isopropanol 70% solutions in multiple-use bottles is commonly used in surgery as a cost-effective method for skin disinfection. However, multiple-use bottles risk contamination. This study aims to test whether bacterial contamination of multiple-use bottles or their solutions occurs once open and on use between different patients. Methods Consecutive samples were taken each time a chlorhexidine bottle was used over a 7-day study period. Samples were tested using blood culture, agar plate and mass spectrometry. Results No growth was observed in 52 samples taken from 18 bottles inoculated into blood culture bottles. Four growths on agar plate culture were determined to be contaminants from the sampling process. Conclusions This study supports the use of multiple-use bottled chlorhexidine solutions as safe and cost-effective in surgical practice.
Direct Support Professionals: Stress and Resiliency Amidst the COVID-19 Pandemic
Authors: Sheppard-Jones Kathy , Kleinert Harold , Butler Laura , Li Jian , Moseley Emily , Adams Chithra 
Published: May 2022

Abstract
This study reports on the results of an online survey of direct support professionals (DSPs) during the COVID-19 pandemic in June 2020 to measure their perceived quality of life, stressors, coping/resilience skills, and knowledge of health care rights directly related to the pandemic for the persons that they support. Specifically, we examined direct support workers' perceptions of their quality of life, levels of stress, and their self-reported resilience skills. We found that perceived stress was strongly correlated with both self-reported quality of life and resilience, but not with years of DSP experience. Moreover, while DSPs overwhelmingly knew and affirmed health care rights for people with disabilities, they were less knowledgeable about their legal rights during hospital stays.
Tunable laser frequency lock based on a temperature-dependent
Fabry–Perot etalon
Authors: Jiang Yuan , Qin Xiateng , Su Dianqiang , Ji Zhonghua , Peng Wenxin , Zhao YanTing 
Published: May 2022

A simple method for laser frequency stabilizing by a temperature-tuned Fabry–Perot
etalon is reported. The etalon is a plano–convex lens that permits
tuning the length and refractive index via controlling the temperature
for shifting wavelengths in the region of 852 nm, with a transmission
spectral linewidth of

∼

72.5

M
H
z

and free spectral region of

∼

16

G
H
z

. Using this scheme, arbitrary
frequency locking of a laser with an adjustable frequency resolution
of

2.34

G
H
z

/

∘

C

is realized, and MHz-level long-term
stability is demonstrated.
Generation of multiple solitons with controllable separation assisted by PM fiber
Authors: Ren Hang , Wang Tianshun , Du Lei , Ma Wanzhuo , Li Baoqun , Zhou Jianhong 
Published: May 2022

A method of generating multiple solitons with controllable separation is proposed by injecting the dissipative soliton (DS) and conventional soliton (CS) into the polarization-maintaining fiber (PMF), respectively. The soliton separation can be adjusted subjectively from 12 to 28 ps, corresponding to PMF lengths from 10 to 24 m. Multiple solitons consisting of three, four, five, and six solitons can be observed at pump powers of 480, 550, 610, and 700 mW. DS’s average single-pulse energy can increase from 20.4 to 40.7 pJ, while the average single-pulse energy of CS decreases from 29.3 to 13.7 pJ. The experimental results can contribute to the further understanding of the dynamics of multiple solitons.