bluuebunny/crossref_metadata_2025_split huggingface dataset:
PET BEREAVEMENT: MENGAJARKAN KONSEP DUKA PADA ANAK
Authors: Juliadilla Risa 
Published: January 2022

Ketika anak berduka atas kematian hewan peliharaanya merupakan suatu keadaan yang rumit. Orang tua hendaknya tidak meremehkan keadaan tersebut namun juga tidak melebih-lebihkan. Sayangnya orang tua seringkali menghindari diskusi topik yang sulit salah satunya adalah kematian, makna kehilangan serta manifestasi emosi yang normal dari kesedihan anak. Padahal Pet Bereavment dapat dijadikan momen, orang tua mengajarkan dengan perspektif lain misalnya menjelaskan pada anak bahwa kehidupan berdampingan dengan kematian, saat terdapat kematian maka juga ada kehidupan baru pada mahluk lain. Hal yang terpenting orang tua mengajarkan konsep kesedihan yang harus ditanggulangi dengan sehat agar anak dapat meneruskan hidupnya. Cara penjelasan mengenai kematian pada anak dapat mempengaruhi anak dalam melewati masa duka. Penjelasan yang tidak tepat berpotensi membuat bingung anak saat memahami konsep kematian. Melalui traditional review, artikel ini bertujuan agar orang tua memahami dan merespon dengan tepat reaksi duka sesuai usia anak serta mengajarkan proses berduka dan menanggulanginya.Kata Kunci: Anak, Pet Bereavement, Orang tua
EFEKTIFITAS PERMENDAG NO 24 TAHUN 2020 TENTANG PENETAPAN HARGA PEMBELIAN PEMERINTAH (HPP) UNTUK GABAH ATAU BERAS DALAM MENGHADAPI KRISIS PETANI DI INDONESIA
Authors: Pahlevi Farida Sekti 
Published: January 2022

Indonesia adalah negara agraris yang sebagian besar masyarakatnya bermata pencaharian sebagai petani. Kebutuhan pangan menjadi hal yang diutamakan demi keberlangsungan hidup bangsa. Kesejahteraan petani dipengaruhi oleh kondisi petani dalam akses pasar dan keuntungan dari hasil panen. Kebijakan hukum pertanian hendaknya dapat memberikan perlindungan terhadap semua tantangan yang dihadapi oleh petani Indonesia khususnya terkait dengan harga hasil panen gabah atau beras. Potensi pertanian yang besar, hendaknya perlu adanya kebijakan pemerintah dalam mensejahterakan kehidupan petani dengan penetapan harga pembelian pemerintah hasil panen khususnya gabah atau beras. Setelah terbitnya permendag no 24 tahun 2020, ternyata masih ditemukan kekecewaan petani terhadap penetapan HPP tersebut. Tujuan dari jurnal ini yaitu, memaparkan efektifitas permendag nomor 24 tahun 2020 dalam menghadapi krisis petani di Indonesia. Adapun metode yang digunakan yaitu studi pustaka bersumber dari jurnal, peraturan-peraturan dan artikel yang berkaitan dengan kebijakan permendag nomor 24 tahun 2020. Hasil dari jurnal ini yaitu menunjukkan bahwa krisis petani di Indonesia terjadi karena adanya ketidakpuasan petani terhadap keuntungan yang didapatkan sehingga masyarakat khususnya generasi muda enggan memilih bermatapencaharian petani. Permendag no 24 tahun 2020 hadir menjadi salah satu bagian ikhtiar pemerintah dalam menjaga stabilitas harga gabah atau beras, akan tetapi belum efektif dalam mencegah krisis petani di Indonesia.
Perumusan Kebijakan Pelayanan Pernikahan Selama Masa Pemberlakuan Pembatasan Kegiatan Masyarakat (PPKM) Darurat
Authors: Sudartono Muhammad , Rachmandhani Muhammad Sulthon 
Published: January 2022

Masa Pemberlakuan Pembatasan Kegiatan Masyarakat (PPKM) membuat seluruh aktivitas masyarakat kembali mengalami kelesuan. Begitu juga dengan kegiatan pelayanan masyarakat yang diselenggarakan oleh instansi pemerintah. Kantor Urusan Agama (KUA) sebagai ujung tombak pelayanan masyarakat dituntut untuk dapat memberikan pelayanan optimal di tengah rambu-rambu penerapan instruksi Direktur Jenderal Bimbingan Masyarakat Islam Nomor P-001/ DJ.III/Hk.007/07/2021. Sehingga kebijakan yang dirumuskan oleh KUA dalam melayani pernikahan merupakan kebijakan yang berorientasi untuk mendukung pemerintah dalam memutus rantai persebaran Covid-19. Oleh karena itu, penelitian ini bertujuan untuk menjelaskan proses perumusan kebijakan yang terdiri dari proses; perumusan k masalah, formulasi kebijakan yang terdiri dari; identifikasi kebijakan, penyusunan agenda kebijakan, membuat proposal kebijakan, dan pengesahan kebijakan. Metode penelitian yang digunakan adalah metode penelitian kualitatif berjenis studi kasus. Teknik pengumpulan data menggunakan wawancara, dokumentasi, dan observasi. Data dianalisis menggunakan teknik analisis Miles-Huberman. Hasil penelitian ini menunjukkan bahwa proses perumusan kebijakan pelayanan pernikahan yang dilakukan oleh KUA selama masa PPKM telah melalui proses perumusan masalah, formulasi kebijakan yang terdiri dari identifikasi kebijakan, proses penyusunan agenda kebijakan, membuat proposal kebijakan, serta pengesahan kebijakan.
A Decision Support System to Enhance Electricity Grid Resilience against Flooding Disasters
Authors: Tavakol-Davani Hassan , Violante Michael , Manshadi Saeed 
Published: January 2022

Abstract
In different areas across the U.S., there are utility poles and other critical infrastructure that are vulnerable to flooding damage. The goal of this multidisciplinary research is to assess and minimize the probability of utility pole failure through conventional hydrological, hydrostatic, and geotechnical calculations embedded to a unique mixed-integer linear programming (MILP) optimization framework. Once the flow rates that cause utility pole overturn are determined, the most cost-efficient subterranean pipe network configuration can be created that will allow for flood waters to be redirected from vulnerable infrastructure elements. The optimization framework was simulated using the Julia scientific programming language, for which the JuMP interface and Gurobi solver package were employed to solve a minimum cost network flow objective function given the numerous decision variables and constraints across the network. We implemented our optimization framework in three different watersheds across the U.S. These watersheds are located near Whittier, NC; Leadville, CO; and London, AR. The implementation of a minimum cost network flow optimization model within these watersheds produced results demonstrating that the necessary amount of flood waters could be conveyed away from utility poles to prevent failure by flooding.
Hallux Valgus Recurrence After Simple Bunionectomy: Algorithm Treatment
Authors: Torrent Josep , Figa Raúl , Clares Iban , Rabat Eduard 
Published: January 2022

Abstract
Background: Recurrences of hallux valgus can be difficult to manage, especially after a prior simple bunionectomy. This study aimed to present a treatment algorithm for the correction of recurrences after a simple bunionectomy.Methods: This was a single-center, descriptive, and retrospective comparative study. Thirty-four consecutive patients were classified according to the bone stock and the presence or absence of end-stage arthritis of the first metatarsophalangeal joint (MTPJ). According to our algorithm, we only performed an osteotomy as the salvage procedure in cases with sufficient bone stock and absence of or mild arthritis. In the other cases, we performed an MTPJ fusion. Exceptionally, we chose a Keller-Brandes arthroplasty for patients with advanced age and comorbidities. Results: We performed 17 scarf osteotomies (50%), 15 MTPJ arthrodeses (44.1%), and 2 Keller-Brandes arthroplasties (5.9%). Following the algorithm, we achieved an improvement of the AOFAS score of >30 points without severe complications in all groups.Conclusions: The proposed operative algorithm successfully addresses the recurrences considering the lack of bone stock and the presence of MTPJ arthritis.Level of EvidenceLevel 3: retrospective comparative study
SARS-Cov-2 Infection in Postmenopausal Women. New Data on Menopause Hormone Therapy
Authors: Baquedano Laura , Navarro Javier , José Yasmina , Tristancho Alexander , Ruiz Ana , Rubio Patricia , Lamarca Marta 
Published: January 2022

Abstract
ObjectiveTo address the factors involved in hospital admission and medical follow up in postmenopausal women with COVID-19 diagnosis.MethodsRetrospective observational study. Postmenopausal women aged between 40-70 years since September 2020 until June 2021 with COVID-19 diagnosis were included. Of the 300 women cohort, 50 were receiving menopause hormone therapy (MHT)Results 288 patients were analyzed. The mean age was 56.20 years (+/-6.06y SD). Age (p=0.030), High blood pressure (HBP) (p=0.002), respiratory disorders (p=0.003), depression (p=0.028) and fibromyalgia (p=0.030) were associated with a greater risk for hospital admission, while MHT was found as a protective factor (p=0.042). Being a health professional (p<0.001), HBP (p=0.029), respiratory disorders (p=0.022), vitamin D deficiency (p=0.010), depression (p=0.005) and fibromyalgia (p=0.001) were related with a longer follow up while MHT was related with a shorter one (p=0.010). Regression analysis showed that HBP and respiratory disorders acted as independent factors for hospital admission while MHT and fibromyalgia were for the length of follow up. ConclusionsMHT has a positive impact in postmenopausal women with SARS-CoV-2 infection. HBP and respiratory disorders are associated with a higher risk of hospital admission of these patients.
First report of rapid, non-invasive, and reagent-free detection of malaria through the skin of patients with a beam of infrared light
Authors: Garcia Gabriela , Kariyawasam Tharanga , Lord Anton , Costa Cristiano , Chaves Lana , Lima-Junior Josué , Maciel-de-Freitas Rafael , Sikulu-Lord Maggy 
Published: January 2022

Abstract
We describe the first application of the Near-infrared spectroscopy (NIRS) technique to detect Plasmodium falciparum and P. vivax malaria parasites through the skin of malaria positive and negative human subjects. NIRS is a rapid, non-invasive and reagent free technique which involves rapid interaction of a beam of light with a biological sample to produce diagnostic signatures in seconds. We used a handheld, miniaturized spectrometer to shine NIRS light on the ear, arm and finger of P. falciparum (n=7) and P. vivax (n=20) positive people and malaria negative individuals (n=33) in a malaria endemic setting in Brazil. Supervised machine learning algorithms for predicting the presence of malaria were applied to predict malaria infection status in independent individuals (n=12). Separate machine learning algorithms for differentiating P. falciparum from P. vivax infected subjects were developed using spectra from the arm and ear of P. falciparum and P. vivax (n=108) and the resultant model predicted infection in spectra of their fingers (n=54).NIRS non-invasively detected malaria positive and negative individuals that were excluded from the model with 100% sensitivity, 83% specificity and 92% accuracy (n=12) with spectra collected from the arm. Moreover, NIRS also correctly differentiated P. vivax from P. falciparum positive individuals with a predictive accuracy of 93% (n=54). These findings are promising but further work on a larger scale is needed to address several gaps in knowledge and establish the full capacity of NIRS as a non-invasive diagnostic tool for malaria. It is recommended that the tool is further evaluated in multiple epidemiological and demographic settings where other factors such as age, mixed infection and skin colour can be incorporated into predictive algorithms to produce more robust models for universal diagnosis of malaria.
The feasibility of Telemedicine in Implementation of Therapeutic Hypothermia for Management of Neonatal Hypoxic-Ischemic Encephalopathy in Resource-Limited Areas.
Authors: Hadid Adnan , AL-Shantout Taher , Terkawi Rayan , Aldbes Baraa , Zahran Manal , Alsatouf Fadia , Najjar Hani , Mughrabieh MHD Hassan , Alhadid Nour , Altirkawi Khalid 
Published: January 2022

Abstract
Background: Telemedicine is widely used in neonatal services in developed countries. Lack of expertise and/or facilities, however, limited its use in developing countries and around areas of military conflicts. To our knowledge, no reports are demonstrating the feasibility of administering therapeutic hypothermia (TH) through telemedicine to neonates with hypoxic-ischemic encephalopathy (HIE) in resource-limited areas.Methodology: This is a retrospective study, evaluating 22 patients who received TH, guided by telemedicine, through a mobile app (Telegram®). We assessed the feasibility of utilizing Telemedicine in guiding the application of TH to infants affected with HIE in the North-West of Syria between July 2020 and July 2021.Results: Out of 5,545 newborn infants delivered during the study period, 22 patients were eligible for TH guided by Telemedicine. Patients were referred for consultation at a median (IQR) of 137 (35-165) minutes of life. A median (IQR) of 12 (3-18) minutes elapsed between the call for a consultation and the consultant response, and a median (IQR) of 30 (0-42) minutes elapsed between seeking the consultation and the initiation of cooling therapy. Eighteen patients completed cooling for 72 hours. The patients' temperatures were within the target range (33-34°C) most of the time (84.1%).Conclusion: Telemedicine is a feasible method to guide the implementation TH for HIE in resource-limited areas. The short-term success rate is relatively high; however, further studies with a larger population are needed to confirm these findings.
WITHDRAWN: Complete Genome Sequence of Unusual Strain of Zika Virus From West Africa
Authors: Gladysheva Anastasia V. , Svyatchenko Victor A. , Bayandin Roman B. , Shvalov Alexander N. , Ternovoi Vladimir A. , Loktev Valery B. 
Published: January 2022

Abstract

In 2018, a Zika infection was detected in patients in the Republic of Guinea. We determined the complete genome sequence of the Faranah/18 strain of Zika virus (ZIKV) isolated using C6/36 cells. The genome sequences are significantly different from those of other African ZIKVs. This isolate has 13 aa substitutions in nonstructural polypeptides, an additional glycosylation site on protein E, and unusual localization of MSI1 binding sites in the 3’-UTR of the African lineage. Additionally, Faranah/18 formed a separate lineage into African genotypes with divergence times near 94 and 646-861 years from Senegal and Uganda ZIKVs, respectively.
Comprehensive bioinformatic analysis of the expression and prognostic significance of TSC22D domain family genes in acute myeloid leukemia
Authors: Xu XiaoQiang , Jin Xin , Wang JiaXi , Sun Rui , Zhang Meng , Xiong Xia , Xie DanNi , Zhao MingFeng 
Published: January 2022

Abstract
Background: TSC22D domain family genes, including Tsc22d1-4, have been extensively reported to be involved in tumors. However, their expression profiles and prognostic significance in acute myeloid leukemia (AML) remain unknown. Methods: The present study investigated the expression profiles and prognostic significance of TSC22D domain family genes in AML through the use of multiple online databases, including the CCLE, EMBL-EBI, HPA, Oncomine,GEPIA2, UALCAN, BloodSpot, and GSCALite databases. The cBioPortal and GSCALite databases were used to explore the genetic alteration and copy number variation (CNV) of the Tsc22d3 gene. The TRRUST (Version 2) database was used to explore the gene ontology biological process, disease ontology, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with the Tsc22d3 gene. The AnimalTFDB3.0, STRING, and Harmonizome databases were used to investigate the protein–protein interaction (PPI) network of the Tsc22d3 gene. The Harmonizome database was used for Tsc22d3 gene regulatory kinase analysis. The TargetScanHuman 7.2, MiRDB, and ENCORI databases were used to execute the analysis of the Tsc22d3 gene regulatory miRNAs. Then, the GSCALite and GEPIA2021 databases were used to investigate the correlation between Tsc22d3 expression and immune infiltration. Results: The expression of the Tsc22d3 gene was upregulated markedly in AML cells relative to normal hematopoietic stem cells. The expression of the Tsc22d3 gene was increased in AML tumor samples compared with healthy bone marrow samples. And overexpression of the Tsc22d3 gene was associated with poor OS in AML patients.This study implied that the Tsc22d3 gene is a new biomarker for predicting the prognosis of AML. Furthermore, gene ontology analysis showed that Tsc22d3 was involved in leukemia. Functional enrichment analysis showed that the Tsc22d3 gene has many biological functions, including the regulation of many genes, kinases, miRNAs, signaling pathways, and immune infiltration.Therefore, this study suggests that the Tsc22d3 gene may be a potential therapeutic target for AML. Conclusions: Tsc22d3 gene expression was upregulated in AML, and overexpression was associated with poor OS in AML patients. Therefore, the Tsc22d3 gene may serve as a novel prognostic biomarker and therapeutic target for AML.
Getting Human Resource Information Systems Right: A Case Presentation of Uganda
Authors: Arakelian Meghan , Brown Andrew N , Collins Alexandra , Gatt Leah , Hyde Sara , Oketcho Vincent , Olum Samson , Schurmann Anna , Siyam Amani 
Published: January 2022

Abstract
BackgroundHuman resources information systems (HRIS) are a key tool for collecting and analyzing health workforce data at the country level and the specific focus of milestones 4.1 and 4.2 of the Global Strategy on Human Resources for Health (HRH). Yet documentation on the capabilities of HRIS in low- and middle-income countries (LMICs) is limited. Vital Wave, with IntraHealth International and Cooper/Smith, conducted a targeted scan of the HRIS landscape in 20 countries and “deep-dive” assessments in Burkina Faso, Mozambique, and Uganda. Here we present the case of Uganda’s workforce information ecosystem. Case PresentationSince 2006, Uganda has seen investment in HRIS from different donors, overseen by the Ministry of Health (MOH) and accompanied by the rollout of IntraHealth’s open-source iHRIS software. Despite this history of investment, mapping of the country’s multiple information systems revealed uneven adoption and engagement nationally and sub-nationally, with high levels of data fragmentation due to lack of interoperability and data-sharing practices. We also mapped the administrative processes and data flows for three priority use cases: recruitment and deployment, salary payments, and performance management. What emerges is a complex, decentralized information ecosystem driven by years of donor investment, but one that still sees uneven ownership and data use across the health system. Challenges include:· Limited interoperability between systems, specifically payroll, iHRIS, and the district health information system (DHIS2)· Complex HRH planning and management policy context, with variable implementation of numerous policies and no single reference to guide investments and implementation· Limited visibility into the private and community health workforce. ConclusionsUganda’s progress in developing its HRH information ecosystem underscores the importance of continuously aligning system capabilities, incentives, and motivations to an ever-evolving country context. However, as evidenced in Uganda and our broader assessment findings, robustness of the information ecosystem itself is insufficient to making substantive strides toward the Global Strategy’s milestones 4.1 and 4.2—governance oversight and ownership are critical to success. With a better understanding of what good looks like in terms of HRIS functionality in LMICs and ensuring interventions are addressing the causal issues, there can be many pathways to making systems work.
Sorghum Agronomic Performance and Soil Chemical and Microbiological Properties as Influenced by Burkina Faso Phosphate Rock-Enriched Composts
Authors: Sagnon Adama , Iwasaki Shinya , Tibiri Ezechiel Bionimian , Zongo Nongma Armel , Compaore Emmanuel , Bonkoungou Isidore Juste O. , Nakamura Satoshi , Traore Mamadou , Barro Nicolas , Tiendrebeogo Fidele , Sarr Papa Saliou 
Published: January 2022

Abstract
Purpose The low availability of phosphorus (P) severely limits crop production in sub-Saharan Africa. We evaluated phosphate rock-enriched composts on soil properties and sorghum growth for use as environment-friendly fertilizers. Methods Treatments were sorghum straw, compost (Comp), Phosphate Rock (BPR), BPR-enriched compost (P-Comp), BPR-soil-enriched compost (P-Comp-Soil), nitrogen-phosphorus-potassium (NPK, 60-90-30), and control without phosphorus and organic material (CT). Sorgum straw and composts were applied at 1.34 tons ha-1. The amounts of nitrogen, phosphorus, and potassium in treatments, except in CT, were adjusted to 60, 90, 30 kg ha-1, with urea, BPR, and KCl, respectively. Sorghum vr. Kapelga was cultivated and soil samples were collected on days 52, 93, and 115 (harvest) for analysis. Results NPK and P-Comp-Soil provided the best sorghum yields. Soil available P was less in these treatments. P-Comp-Soil-amended soils recorded higher populations of bacteria (16S rRNA), acid phosphatase (aphA), phosphonatase (phnX), glucose dehydrogenase (gcd) and its cofactor pyrroloquinoline quinone (pqqE) genes. Phosphate-specific transporter (pstS) and arbuscular mycorrhizal fungi (AMF) abundances were generally higher in P-Comp-Soil soils, especially at the early growth stage. This active microbial activity in the P-Comp-Soil added to its initially higher available P justified a better nutrient uptake and yields comparable to NPK. Multivariate analysis also revealed the contribution of nitrogen, carbon, and exchangeable cations in sorghum growth. Conclusion This study demonstrated that direct phosphate rock application is not effective in sub-Saharan African upland cultivation. Alternative to chemical fertilizers, soils may be amended with phosphate rock-enriched composts, a niche of beneficial microbes improving soil health.
Impact of JAK Inhibitors in Pediatric Patients with STAT1 Gain-of-Function (GOF) Mutations – 10 Children and Review of the Literature
Authors: Deya Angela , Riviere Jaques Gabriel , Roxo-Junior Persio , Ramarkers Jan , Bloomfield Marketa , Hernandez Paloma Guisado , Lobo Pilar Blanco , Jamra Soraya Regina Abu , Esteve-Solé Ana , Kanderova Veronika , Garcia-Garcia Ana , Corbeto Mireia Lopez , Pomar Natalia Martinez , Nalda Andrea Martin , Alsina Laia , Neth Olaf , Olbrich Peter 
Published: January 2022

Abstract
Introduction. Since the first description of gain of function (GOF) mutations in Signal Transducer and Activator of Transcription (STAT) 1, more than 300 patients have been described with a broad clinical phenotype including infections and severe immune dysregulation. Whilst Jak inhibitors (JAKinibs) have demonstrated benefits in several reported cases, its indications, dosing and monitoring remain to be established. Methods. A retrospective, multicenter study recruiting pediatric patients with STAT1 GOF under JAKinib treatment was performed and, when applicable, compared with the available reports from the literature. Results. Ten children (median age 8.5y (3-18), receiving JAKinibs (ruxolitinib (n=9) and baricitinib (n=1)) with a median follow-up of 18m (2-42) from 6 inborn errors of immunity (IEI) reference centers were included. Clinical profile and JAKinib indications in our series were similar to the previously published 14 pediatric patients. 9/10 (our cohort) and 14/14 patients (previous reports) showed partial or complete responses. The median immune deficiency and dysregulation activity scores were 15.99 (5.2-40) pre and 7.55 (3-14.1) under therapy (p=0.0078). Infection, considered a likely adverse event of JAKinib therapy, was observed in 1/10 patient; JAKinibs were stopped in 3/10 children, due to hepatotoxicity, pre HSCT and absence of response. Conclusions. Our study supports the potentially beneficial use of JAKinibs in patients with STAT1 GOF, in line with previously published data. However, consensus regarding their indications and timing, dosing, treatment duration and monitoring, as well as defining biomarkers to monitor clinical and immunological responses, remains to be determined, in form of international prospective multicenter studies using established IEI registries.