bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-refractive index and mechanically cleavable non-van der Waals InGaS3
Authors: Ghazaryan Davit , Toksumakov Adilet , Ermolaev Georgy , Slavich Alexander , Doroshina Natalia , Sukhanova Ekaterina , Yakubovsky Dmitry , Syuy Alexander , Novikov Sergey , Oreshonkov Aleksandr , Tsymbarenko Dmitry , Popov Zakhar , Kvashnin Dmitry , Vyshnevyy Andrey , Arsenin Aleksey , Volkov Valentyn 
Published: July 2022

Abstract
The growing families of two-dimensional crystals derived from naturally occurring van der Waals materials offer an unprecedented platform to investigate elusive physical phenomena and could be of use in a diverse range of devices. Of particular interest are recently reported atomic sheets of non-van der Waals materials, which could allow a better comprehension of the nature of structural bonds and increase the functionality of prospective heterostructures. Here, we study the optostructural properties of ultrathin non-van der Waals InGaS3 sheets produced by standard mechanical cleavage. Our ab initio calculation results suggest an emergence of authentically delicate out-of-plane covalent bonds within its unit cell, and, as a consequence, an artificial generation of layered structure within the material. Those yield to singular layer isolation energies of ~ 50 meVÅ-2, which is comparable with the conventional van der Waals material’s monolayer isolation energies of 20 - 60 meVÅ-2. In addition, we provide a comprehensive analysis of the structural, vibrational, and optical properties of the materials presenting that it is a wide bandgap (2.73 eV) semiconductor with a high-refractive index (> 2.5) and negligible losses in the visible and infrared spectral ranges. It makes it a perfect candidate for further establishment of visible-range all-dielectric nanophotonics.
A tunable metal free perfect absorber based on hybrid graphene-dielectric metasurface in the mid-infrared regime
Authors: Xu Wei , Cheng Hongbo , Luo Xin , Cheng Ziqiang , Ke Chan , Zhai Xiang 
Published: July 2022

Abstract
Since the metal-based optical absorbers will introduce some disadvantages, such as low melting point, easy conductivity and thermal conductivity, these factors limit their further application in thermophotovoltaics, modulators, photodetector and other fields. In this paper, a tunable metal free perfect absorber based on hybrid graphene-dielectric metasurface is proposed in the mid-infrared regime. According to the results of finite-difference time-domain (FDTD) method, a perfect absorption peak realizes at the wavelength of 9059 nm, which can be explain by using the coupled mode theory, and the absorption of the structure can be dynamically adjusted by changing the Fermi energy of graphene film. Moreover, the absorption performance of this metal free structure manifests polarization insensitive and keeps good for wide angles of incidence. Therefore, we believe our proposed absorber has great application potential in the fields of photovoltaic and thermal detection.
Sex differences in the sustained attention of elementary school children
Authors: Barel Efrat , Tzischinsky Orna 
Published: July 2022

Abstract
Background: The study investigates sex differences in sustained attention among children. Methods: Forty-five children (23 girls) from Grades 2 to 5 (mean age of 7.47±0.73 years) wore an actigraph for a continuous five to seven days including school and non-school days. Sustained attention using the Psychomotor Vigilance Test (PVT) was measured twice a day on two school days and on one non-school day. Results: No sex differences were found for sleep patterns. However, sex differences in PVT performance were documented. While boys were faster (shorter reaction time) and showed fewer lapses than girls, they showed higher number of false starts than girls, on both weekdays and weekends. Conclusions: The findings suggest that sex differences should been taken into account in studies investigating neurobehavioral functioning, particularly, sustained attention across various age groups.
Administration of Granulocyte-macrophage colony-stimulating factor enhanced CAR T-cell expansion and cellular immunity recovery without inducing cytokine release syndrome：a retrospective study
Authors: Jiang Ying , Feng Dan , Wang Chun , Zhang Yanlei , Zhao Chuxian , Li Su , Qin Youwen , Chang Alex H. , Zhu Jun 
Published: July 2022

Abstract
Background
Leukopenia and cytokine release syndrome (CRS) are two major toxicities of CAR-T cell therapy. GM-CSF is an ideal candidate treatment for leukopenia except for its potential aggravation of CRS. We hypothesized that the optimal timing of supplemental with GM-CSF in a shortage of host immunity and CAR T-cell was chosen as avoidance of CRS. In the study we evaluated the safety and efficacy of GM-CSF intervention post-CAR T-cell therapy while circulating CAR T-cell declined.
Methods
Nine patients received GM-CSF therapy who displayed moderate leukopenia with white blood cell counts (WBC) < 3000 cells/mm3 and absolute neutrophil counts (ANC) < 1500 cells/mm3 with concomitant declination of circulating CAR T-cell after CAR T-cell therapy.
Results
The median duration of GM-CSF intervention was 15 days (4–30). CAR T-cell expansion was observed in eight patients (8/9), including cerebrospinal fluid of one patient and peripheral blood (PB) of other seven patients. And the peaks of CAR T-cell levels in cerebrospinal fluid and PB appeared in day 6 and day 7 (2–11) following the initiation of GM-CSF administration. Also, increased white blood cells in PB was observed in all patients. The median onset and duration time of WBC recovery were 9 (1–14) and 17(3–53) days. Moreover, the increment of WBC, neutrophil, lymphocyte and CD3-CD16 + CD56 + natural killer cell in PB was observed. In addition, no CRS or fatal infection occurred during GM-CSF treatment.
Conclusion
This study provides evidence for the clinical feasibility of combining CAR T-cell therapy with the GM-CSF to treat leukopenia patients with concomitant declination of circulating CAR T-cell.
Numerical simulation of fault deformation and seismic activity in the southern Qinghai–Tibet Plateau
Authors: Li Yuan , Liu Xia , Rodkin Mikhail , Pang Yajin 
Published: July 2022

Abstract
The moderate-strong (M ≥ 5, since 1976; or M ≥ 6.5, overall) earthquakes of the north and south trending (NS-trending) faults and their adjacent in the southern Qinghai–Tibet Plateau has prominent spatial concentration distribution characteristics. However, research on the relationship between southern Tibet faults is limited. Hence, this study used a two-dimensional viscoelastic finite element model to simulate crustal movement in southern Tibet based on 1991–2015 GPS velocity data. The current deformation field, tectonic stress field, fault slip, and stress accumulation rate distribution were obtained to determine the relationship between fault activity and earthquake distribution. The results showed that the research area was simultaneously affected by NE-trending compression and uneven EW-trending tensile force, and crustal deformation exhibited simultaneous NS-trending compression and EW-trending stretching. The EW- and NWW-trending faults around the research area and the internal NS-trending faults differed in their mechanical properties and movement modes. NS faults were primarily subjected to extension stress with normal motion. Remarkable differences were appeared between different fault segments, controlling of distribution of moderate-strong earthquakes, and types of earthquake ruptures. The concentrated distribution of moderate-strong (M ≥ 5, since 1976; or M ≥ 6.5, overall) earthquakes on the NS-trending normal fault and its vicinity depended largely on the high slip rate, strong tensile stress and geometric strike of the fault segment. This study is helpful to fully understand the differences in normal fault activity in southern Tibet, and is also the basis for seismic risk assessment.
Novel vitamin K3 analogues containing 3-N-substituted aromatic and piperazine rings with selective in vitro anticancer activity against HeLa, U87 MG, and MCF-7
Authors: Abdassalam Aesha FSH. , Deniz Nahide Gulsah , SAYIL CIGDEM , Onay-Ucar Evren , Mertoglu Elif , Arda Nazli 
Published: July 2022

Abstract
In this study, firstly, five novel vitamin K3 analogues were synthesized by the reactions of vitamin K3 (2-methyl-1,4-naphthoquinone, also known as menadione) with some aromatic and heterocyclic ring substituted nucleophiles such as 2,4-dimethoxyaniline, 4-methoxyaniline, 4-benzylpiperidine and 1-(2-aminoethyl)piperazine in ethanol/Na2CO3, and 1-(diphenylmethyl)piperazine in chloroform/triethylamine (TEA) at room temperature. Their structures were elucidated by Fourier transform infrared spectroscopy (FT-IR), 1H nuclear magnetic resonance (1H NMR), attached proton test nuclear magnetic resonance (APT-NMR) and mass spectrometry (MS). Secondly, in vitro cytotoxic effects of vitamin K3 analogues were investigated by MTT assay against three cancer cell lines (HeLa, U87 MG, and MCF-7) to evaluate their anticancer activity and a human embryonic kidney cell line (HEK-293) to check their cancer cell selectivity. One of the compounds, namely 2-((2,4-dimethoxyphenyl)amino)-3-methylnaphthalene-1,4-dione, was found to inhibit the growth of HeLa cervical cancer cells selectively, even better than vitamin K3, at a non-toxic concentration for healthy cells. The selectivity index of this compound for HeLa cells was calculated approximately as 3. Vitamin K3 was more effective against U87 MG and MCF-7 cells than its derivatives, moreover it was the only compound, which was significantly toxic to breast cancer cells, but its selectivity was poor. Furthermore, anticancer properties of piperazine derivatives of vitamin K3 were investigated by us for the first time in this study.
Mitochondrial COX 1 gene sequence based molecular identification of chelonian tick Amblyomma geoemydae with special prominence on phylogenetic perusal, from Kerala, India.
Authors: Athira Kumichiyil Kumaran , Anis Kupzhuppilly Varghese , Aneesh Embalil Mathachan , Aneesh Embalil Mathachan 
Published: July 2022

Abstract
Genetic assessment and morphological features of a chelonian tick, Amblyomma geoemydae -Cantor, 1847 were determined for the first time in Kerala. Morphological features of Amblyomma geoemydae nymph were examined and photographed by using a high-quality ZIEZZ (Discovery.V20) microscope. The juvenile tick was identified as Amblyomma geoemydae evincing diverse external characters including the edge of the basis capituli is a round shape without cornua, hypostomal dental formula is 2/2, and the second segment of the palp is longer than the first and third. On the edge of the angular scutum have a pair of slightly convex eyes. The genetic confirmation was scrutinized by using sequences of mt COX1 gene. This investigation revealed the first molecular confirmation of A. geoemydae from Wayanad, Kerala. The evolutionary relationship was examined via neighbor-joining analysis and the phylogenetic tree was constructed through the Maximum Likelihood method. The identified A. geoemydae is genetically associated with some species under the same genera with high sequence similarity including A. marmoreum, A. ovale, and A. naponense. Some other species exhibit more sequence divergence such as A. imitator, and A. humerale. The findings provide evidence of dispersal of Ehrlichia, Francisella, and Borrelia miyamotoi vector have a significant role in Lyme disease and relapsing fever.
Assessment of different based regions of interest methods for [99mTc]Tc DAT-SPECT quantification using an anthropomorphic striatal phantom.
Authors: Alexandre-Santos Leonardo , Trevisan Ana Carolina , Pitella Felipe Arriva , Tumas Vitor , Silvah José Henrique , Kato Mery , Moraes Eder Rezende , Wichert-Ana Lauro 
Published: July 2022

Abstract
Background and Aims: Molecular imaging of the dopamine transporters (DAT) provides usefull information about neurodegenerative diseases, such as Parkinson’s. This study assessed the accuracy and precision of DAT-SPECT quantification methods. Methods: Twenty-three DAT-SPECT images of a striatal phantom. The specific chambers (caudate and putamen) and the nonspecific background activity chamber were filled with 99m Tc in different specific to nonspecific ratios of activity (10, 8, 6, 4 and 2 to 1). Then, the specific binding ratio (SBR) was determined. Five methods using ROIs were assessed: (a) Manual ROIs on SPECT images; (b) TwoBox and (c) ThreeBox Methods and VOIs using structural images; (d) MRI and (e) CT. Accuracy was evaluated by the concordance correlation coefficient (CCC) and precision by the Pearson’s coefficient and linear regression. Results: The SBR quantified in the specific and striatal chambers resulted in a CCC increase with a decrease of the nominal values used. For lower SBR, MRI and CT showed higher CCCs when caudate (CCC MRI-CA = 0.89 e CCC CT-CA = 0.84) and putamen (CCC MRI-PU = 0.86 e CCC CT-PU = 0.82) were evaluated. For striatal assessments, the TwoBox method was the most accurate (CCC TWOBOX-ST = 0.95). High Pearson’s coefficients were found in the correlations between all methods. Conclusions: All five methods showed high precision even when applied in images with different activity. For the individual assessment of the caudate or putamen, MRI and CT were the most accurate. To assess the striatal chamber and in the absence of structural information, the TwoBox method is advisable.
Exogenous Ca2+ Regulating Nitrogen Assimilation for Improving Yield and Quality of Rice under Acid Rain Stress
Authors: Zhang Yuanqi , Liang Chanjuan 
Published: July 2022

Abstract
Acid rain threatens crop yield and nutritional quality, and Ca2+ can regulate plant responses to abiotic stresses. To improve the yield and nutritional quality of crops under acid rain stress, we applied exogenous Ca2+ to regulate nitrogen assimilation in rice seedlings under simulated acid rain stress (SAR, pH 4.5 or 3.0), taking yield and nutritional quality of rice as evaluation criteria. We found that Ca2+ (5 mM) maintained the total nitrogen content of rice at the seedling and booting stages to alleviate the inhibitory effect of SAR on rice yield. Meanwhile, Ca2+ improved the activity of glutamate synthase to eliminate the disruption of glutamine synthetase/glutamate synthase balance under SAR. It decreased the efficiency of nitrogen assimilation, thereby reducing the inhibition of essential amino acid content in rice. The mitigation effect on pH 4.5 SAR was better than pH 3.0 SAR. Overall, Ca2+ may reduce the negative effect of acid rain on yield and nutritional quality of crops.
Evaluation of a Novel Case-Based Teaching Series for First Year Otolaryngology – Head &amp; Neck Surgery Residents
Authors: Wang Lily , Henley Jessica , Philteos Justine , Horton Garret , Levin Marc , Saleem Ahmed , Monteiro Eric , Lin Vincent , Chan Yvonne , Campisi Paolo 
Published: July 2022

Abstract
Introduction
First-year resident physicians began training in July 2020 in an environment of decreased clinical case exposure and increased feelings of insecurity secondary to the coronavirus (COVID-19) pandemic. To support resident learning, the University of Toronto Department of Otolaryngology - Head & Neck Surgery piloted a novel virtual case-based discussion series for first-year residents.
Methods
A weekly virtual resident-led case-based discussion series was designed. In 2020/2021, six residents (“Cohort 1”) and four staff otolaryngologists participated. A Likert survey retrospectively evaluated participant comfort level on a scale of 1 to 5, from “not well prepared or comfortable” to “very well prepared or comfortable” in seven clinical areas, at the beginning of the post-graduate year (PGY-1) August 2020, and in May 2021. Qualitative data collected assessed strengths and weaknesses of the intervention. In July 2021, the new 2021/2022 PGY-1 cohort (“Cohort 2”) also completed cross-sectional surveys in August 2021 and March 2022 to assess their comfort levels with consult management at the two separate timepoints.
Results
Cases presented revealed areas for practical, systemic, and cultural improvement. With respect to clinical decision making, both “Cohort 1” and “Cohort 2” residents reported increased comfort level in all areas assessed. “Cohort 1” residents reported percentage increase in comfort level addressing all consults of 28%, triaging consults overnight of 24%, pediatric consults of 30%, otology consults of 32%, airway consults of 30%, epistaxis consults of 28%, and peritonsillar abscess consults of 24%. “Cohort 2” residents reported increase in comfort level managing all consults of 32%, triaging consults overnight of 30%, pediatric consults of 38%, otology consults of 2%, airway consults of 30%, epistaxis consults of 18%, and peritonsillar abscess consults of 24%. All respondents agreed the intervention would benefit residents of other programs as a prolonged orientation to residency and a safe and confidential forum to discuss best practices.
Discussion
A weekly case discussion series potentially improves both resident education and patient care. It facilitated real-time discussion of topics relevant to self-perceived knowledge deficits, timely advice on management of a new and changing population of COVID patients and brought to attention hidden curriculum topics for exploration.
Conclusion
The case series described could be applied to benefit residents in Otolaryngology and other surgical specialty programs nationwide during, and following, the pandemic.
Sustainable circular economy production system with emission control in LED bulb companies
Authors: John Ezhilarasan Peter , Mishra Umakanta 
Published: July 2022

Abstract
Mother Earth has a completely sustainable circular life cycle pattern. In its life cycle, there is no harm created to any living creature or to the environment. In this paper, a sustainable circular economic production and consumption system in a led bulb firm that follows the same cycle pattern as our planet is developed. The circular economy concept, green technology, and carbon cap- and- trade policy is introduced in this model to control the carbon emission rate and resource depletion in LED firms. The profit function is maximized by Lagrange’s multipliers method and Karush-Kuhn-Tucker (KKT) criteria. The optimal order quantity and circularity index of the LED bulb are found for a wise production process. The concavity of the optimal profit function is proved by using the Hessian matrix method. Different linear and non-linear combinations of demand and profit functions were discussed. This article claims that the circularity level of LED bulbs has influenced their selling price, cost, and demand. The green technology and carbon cap and trade policy enhanced the sustainability of LED bulb companies. To get a clear understanding of the implication of this model in LED bulb companies the numerical examples, result in discussion and optimal solution table are provided. Sensitivity analysis is presented. Managerial implication explained in terms of arrived results. Limitations and possible future extensions of this model are given in the conclusion section.
Exploring the Knowledge, Thoughts, and Experiences of Virtual Reality Training in Elite Football and Baseball.
Authors: Dowsett Ross , Kinrade Noel , Lawson Dillon , Whiteside David , Barnett Cleveland , Magistro Daniele , Wilkins Luke 
Published: July 2022

Abstract
Despite the perceived benefits of implementing virtual reality (VR) training in elite sport (Gray, 2019), arguably the most important element – the thoughts, knowledge, and experiences of practitioners – has been largely understudied. Therefore, the present study aimed to explore practitioners’ knowledge of VR, current and past usage, important factors for implementation, and perceived obstacles in elite football and baseball via an online questionnaire. Football respondents (n = 25) represented practitioners from major football leagues across the world, and baseball respondents (n = 15) represented practitioners from Major League Baseball. Both football and baseball respondents reported that the most important factor for implementation of VR training was improvement in on-field performance, whether this be mental, tactical, or technical. Furthermore, both football and baseball respondents highlighted cost as the biggest obstacle at their current club. Notably, Mann-Whitney U tests revealed that football respondents perceived coach (p = .02) and executive approval (p < .001) as significantly greater obstacles than baseball respondents. Regression analyses showed that a lack of executive approval was best predicted by the obstacle of cost (p = .02), whereas a lack of coach approval was best predicted by general negative perceptions of VR (p < .01). Mann Whitney U tests also revealed that football respondents had a significantly higher mean rating for obstacles (p < .01) and significantly lower perceived knowledge of sport-specific VR than the baseball respondents (p < .001). These findings have considerable implications with regard to the potential application of VR training in football and baseball.
Clinical heterogeneity and molecular characteristics in a group of Chinese patients with dysferlinopathy
Authors: Wang Ning , Han Xu , Hao Shengpu , Han Jingzhe , Sun Shuyan , Tang Jin , Lu Yanpeng , Wu Hongran , Ma Shaojuan , Ji Guang , Song Xueqin 
Published: July 2022

Abstract
Background
Dysferlinopathy is an autosomal recessive muscular dystrophy caused by mutations in the dysferlin (DYSF) gene. This study presents the clinical features and mutational spectrum of a Chinese cohort.
Methods
We reviewed the clinical, pathological data and results of DYSF mutations of 26 Chinese patients with dysferlinopathy screened by immunohistochemistry staining and mutations in DYSF genes.
Results
Among 26 patients with dysferlinopathy, 18 patients (69.2%) presented as LGMD2B, 4 (15.4%) had a phenotype of Miyoshi myopathy (MM), and 4 (15.4%) presented as atypical asymptomatic hyperkalemia(hyperCKemia). 15 patients (57.7%) were originally misdiagnosed as inflammatory myopathy or other diseases. 15 novel mutations were identified among the 40 mutation sites identified in this cohort.
Conclusions
Dysferlinopathy is a clinically heterogeneous group of disorders with various phenotypes, and has a high proportion of novel mutations and a high rate of misdiagnosis before immunohistochemistry staining and genetic analysis.