bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, Stress Analysis, and FEA Prediction of Nutation Drive with Face
Gear
Authors: Wang Guangxin , Zhu Lili , Li Linjie , Wang Jiayu 
Published: September 2022

Background:
Nutation face gear transmission is a patent about a new type of transmission
based on meshing between two face gears. It replaces spur gear with internal face gear to form a “faceface” meshing gear pair and actualizes its deceleration function by combining the nutation principle,
which has the advantages of both face gear and nutation drive.

Objective:
The purpose of this paper is to study the designing and manufacturing of a nutation face gear
reducer to derive the force calculation formulas of the face gear, input shaft and bearings, calculate the
contact stress of tooth surface and bending stress of tooth root, determine the basic parameters of the
prototype, and analyze the processing points for the core parts of the prototype.

Methods:
Using the dynamic meshing force analysis method by combining it with modern digital design and manufacturing methods, the designing and manufacturing of a nutation face gear reducer are
studied.

Results:
In the theoretical calculation, the maximum contact stress of the fixed side tooth surface is
about 433MPa, and the average contact stress is about 345MPa; the maximum contact stress of the tooth
surface on the rotating side is about 579MPa, with an average of about 502MPa; the comparison of
which with the finite element analysis results verifies the theoretical calculation results.

Conclusion:
The dynamic meshing force analysis method of nutation face gear transmission is deduced
and given. Based on this, gear tooth surface transient contact stress and tooth root bending stress are
calculated.
Multidrug-Resistant Acinetobacter baumannii: An Emerging Aspect
of New Drug Discovery
Authors: Jain Chakresh Kumar , Mittal Khushi R. , Jain Nandini , Srivastava Poornima 
Published: September 2022

Background:
Acinetobacter baumannii is an opportunistic multidrugresistant,
aerobic, glucose non-fermentative, and oxidative-negative coccobacilli bacteria.
This life-threatening nosocomial infection is associated with immunocompromised
patients.

Objective:
This review aims to investigate the multiple drug resistance mechanisms and
new emerging diagnostics & treatments for Acinetobacter baumannii.

Methods:
All the articles that were most relevant to A. baumannii virulence and drug
resistance mechanisms were founded by a literature search on PubMed. Google Patents
were used to find discoveries related to diagnostics and treatment.

Results:
Efflux pumps, β-lactamases, aminoglycosides, outer membrane proteins, and
alteration of the target sites were identified in the Acinetobacter baumannii pathogen as
the most prevalent drug resistance mechanisms. Gene detection, peptide detection, and
antigen-antibody-associated detection were the latest diagnostics. Novel antimicrobial
peptides, sterilization techniques using blue light, and combination therapies are being
developed to effectively treat A. baumannii infections.

Conclusion:
This review concludes that new drugs and formulations with high efficiency,
low cytotoxicity, and no nephrotoxicity are in absolute need. In the near future, we
can expect omics technology to play a significant role in discovering new drugs and potential
targets.
The Potential Therapeutic Properties of Prunetin against Human Health
Complications: A Review of Medicinal Importance and Pharmacological
Activities
Authors: Patel Dinesh Kumar , Patel Kanika 
Published: September 2022

Background:
Flavonoids are polyphenolic compounds found to be present in nature
and abundant in flowers and fruits. Flavonoidal class phytochemicals have gained interest in the
scientific field because of their important pharmacological activities. Several scientific studies
have revealed anti-bacterial, anti-oxidant, anti-fungal, analgesic, anti-viral, anti-inflammatory,
anti-tumor, anti-parasitic and anti-allergic activities of flavonoidal class phytochemicals. Prunetin
is an O-methylated isoflavone that belongs to the phytochemical phytoestrogen class, found to be
present in licorice, red cherry, soybean and legumes.

Methods:
Biological potential and pharmacological activities of prunetin have been investigated
in the present work through scientific data analysis of numerous scientific research works. Numerous
literature databases have been searched in order to collect the scientific information on
prunetin in the present work. Pharmacological activities of prunetin have been investigated in the
present work through literature data analysis of different scientific research works. Scientific data
have been collected from Google Scholar, Google, PubMed, Science Direct and Scopus. Analytical
data on prunetin has been collected from literature sources and analyzed in the present work.

Results:
Scientific data analysis revealed the biological importance of prunetin in medicine.
Prunetin was found to be present in the pea, peach, Oregon cherry, skimmed cheese, cheese, cow
kefir and goat kefir. Prunetin is also present in the Prunus avium, Andira surinamensis, Butea superba,
Dalbergia sympathetica, Ficus nervosa, Pterospartum tridentatum and Pycnanthus angolensis.
Pharmacological data analysis revealed the biological importance of prunetin on bone disorders,
cancers, especially hepatocellular carcinoma, urinary bladder cancer, gastric cancer, ovarian
cancer, human airway, gut health and enzymes. Scientific data analysis revealed biological effectiveness
of prunetin for their angiogenic effects, anti-inflammatory, anti-oxidant, antimicrobial,
estrogenic and vasorelaxant potential. Analytical data revealed the importance of modern
analytical techniques for qualitative and quantitative analysis of prunetin in the scientific
fields.

Conclusion:
Scientific data analysis in the present investigation revealed the biological importance
and pharmacological activities of prunetin in medicine.
Sleep disorders in meningoencephalitis with adjustment disorders
Authors: Siahaan Sarah Endang S. , Ariani Ni Ketut Putri , Utami Desak Ketut Indrasari 
Published: September 2022

Many patients with medical disorders, such as meningoencephalitis are evaluated by psychiatrists complaining of sleep problems as one of the symptoms. A 65-years old married male patient who was currently unemployed was interviewed by a psychiatrist in an uncomfortable reclining position. The patient had been hospitalized for 8 days prior to the interview with a history of being unconscious. The patient showed disorganized speech, tried to pull the intravenous line, and hit his wife. The patient said that at this time, he was unable to sleep due to the throbbing headaches, nauseous, and frequent urination at night. Thus, the patient felt uncomfortable, tired, and drowsy in the morning. Those symptoms got worse in the last week. The patient never had sleep problems before. The psychiatric status showed an appropriate appearance, uncomfortable looks, adequate verbal and visual contact, clear consciousness, dysphoric mood and affect which was congruent, logical realist coherent thought process, and a preoccupation of headache. There was no hallucination or illusion, but mixed type insomnia was found. The patient was diagnosed with adjustment disorder with predominant symptoms and sleep disturbances (F43.28).
Investigación de parámetros bioquímicos y perfil de citocinas en ovejas con ectima contagioso
Authors: Polat-Dinçer Pelin Fatoş , Şahan Adem 
Published: September 2022

Objective. Contagious ecthyma is a worldwide zoonotic disease with a wide host range and high morbidity that causes serious economic losses. Materials and methods. 28 unvaccinated sheep aged 1-4 months showing clinical symptoms of ecthyma and 10 healthy sheep in the same age range were used. Measurements were taken of ALB, ALT, BUN, CHOL, CRE, GGT, GLU, TBIL and TP. The obtained crusts were homogenized before performing extraction and PCR. ELISA was used to determine IL-2 and IL-4 levels in the PCR-positive animal serum. Results. The biochemical analysis revealed that ALT, BUN, GGT, and CRE values in infected animals were significantly higher than in the control group (p=0.000 and p= 0.001) whereas TP and GLU values were significantly lower (p=0.000). There were no significant differences in ALB, CHOL, and TBIL values (p=0.1, p=0.05, p=0.08). Regarding the immune profile, infected animals had significantly higher IL-2 (%28) and IL-4 (%60) levels than the control group (p=0.008 and p=0.001). Conclusion. The findings indicate that Th1 (IL-2) and Th2 (IL-4) cytokines coexist while the dominant cytokine response in infected animals is Th2. It is thought that the result will help us better understand the pathogenesis and treatment options of the disease.
Challenges in Recruiting University Students for Web-Based Indicated Prevention of Depression and Anxiety: Results From a Randomized Controlled Trial (ICare Prevent)
Authors: Bolinski Felix , Kleiboer Annet , Neijenhuijs Koen , Karyotaki Eirini , Wiers Reinout , de Koning Lisa , Jacobi Corinna , Zarski Anna-Carlotta , Weisel Kiona K , Cuijpers Pim , Riper Heleen 
Published: September 2022

Background
Depression and anxiety are common mental health conditions in college and university student populations. Offering transdiagnostic, web-based prevention programs such as ICare Prevent to those with subclinical complaints has the potential to reduce some barriers to receiving help (eg, availability of services, privacy considerations, and students’ desire for autonomy). However, uptake of these interventions is often low, and accounts of recruitment challenges are needed to complement available effectiveness research in student populations.

Objective
The aims of this study were to describe recruitment challenges together with effective recruitment strategies for ICare Prevent and provide basic information on the intervention’s effectiveness.

Methods
A 3-arm randomized controlled trial was conducted in a student sample with subclinical symptoms of depression and anxiety on the effectiveness of an individually guided (human support and feedback on exercises provided after each session, tailored to each participant) and automatically guided (computer-generated messages provided after each session, geared toward motivation) version of ICare Prevent, a web-based intervention with transdiagnostic components for the indicated prevention of depression and anxiety. The intervention was compared with care as usual. Descriptive statistics were used to outline recruitment challenges and effective web-based and offline strategies as well as students’ use of the intervention. A basic analysis of intervention effects was conducted using a Bayesian linear mixed model, with Bayes factors reported as the effect size.

Results
Direct recruitment through students’ email addresses via the central student administration was the most effective strategy. Data from 35 participants were analyzed (individually guided: n=14, 40%; automatically guided: n=8, 23%; care as usual: n=13, 37%). Use of the intervention was low, with an average of 3 out of 7 sessions (SD 2.9) completed. The analyses did not suggest any intervention effects other than anecdotal evidence (all Bayes factors10≤2.7).

Conclusions
This report adds to the existing literature on recruitment challenges specific to the student population. Testing the feasibility of recruitment measures and the greater involvement of the target population in their design, as well as shifting from direct to indirect prevention, can potentially help future studies in the field. In addition, this report demonstrates an alternative basic analytical strategy for underpowered randomized controlled trials.

Trial Registration
International Clinical Trials Registry Platform NTR6562; https://tinyurl.com/4rbexzrk

International Registered Report Identifier (IRRID)
RR2-10.1186/s13063-018-2477-y
Prevalencia de la clasificación del ponticulus posticus en pacientes de nueve a 25 años en una población en Cuenca-Ecuador
Authors: Becerra-Moreira María Auxiliadora , Pacheco-Pesántez Diana Estefanía , Vidal-Dávila Tatiana Alexandra , Villavicencio-Caparó Ebingen , Cruz-Hervert Luis Pablo , Barzallo-Sardi Vinicio 
Published: September 2022

Objetivo: Determinar la prevalencia del ponticulus posticus en radiografías digitales laterales de cráneo. Material y métodos: Se seleccionaron aleatoriamente radiografías digitales laterales de cráneo de la base de datos de un centro de radiología oral y maxilofacial de la ciudad de Cuenca, Ecuador, de pacientes entre nueve y 25 años entre 2013-2015. Se estimó la prevalencia del ponticulus posticus según la clasificación de Cederberg y Stubbs y se estratificó por sexo. Se realizó un análisis de regresión multivariante multinomial para comparar la asociación entre edad y sexo con la clase 2, 3 y 4 frente a la clase 1. Los datos se analizaron en el programa STATA V13.0. Resultados: Se analizaron 1,000 radiografías laterales de cráneo, la edad promedio fue de 15 (± 4.23) años y 57.60% (n = 424) eran mujeres. La prevalencia de clase 1 fue de 71.8% (IC 95% 68.92-74.51), clase 2 fue 16.5% (IC 95% 14.32-18.94), clase 3 fue 5.5% (IC 95% 4.24-7.10) y clase 4 fue 6.20% (IC del 95%: 4.86 a 7.88). Según el análisis multivariado, se identificó que los hombres tenían mayor posibilidad de tener una clase 2 o 3 que clase 1, mientras que los pacientes mayores eran clase 4 en comparación con clase 1. Conclusiones: Ponticulus posticus es una variante anatómica de alta prevalencia en la población estudiada. En la clasificación de Cederberg y Stubbs se observó mayor prevalencia de la clase 1 de ponticulus posticus. La calcificación se extiende a menos de la mitad de la arteria vertebral. Los hombres mostraron mayor prevalencia de clase 2. El aumento de la frecuencia de clase 4 se asoció con el aumento de la edad. La clase 1 de la misma clasificación no tenía importancia clínica, ya que no se observó calcificación de ningún tipo.
A study of relationship between SARS-CoV-2 antibodies levels and host factors among general population in Zakho City, Iraq
Authors: R Hussein Nawfal , A Naqid Ibrahim , A Jamal Shakir , Balatay Amer , Ibrahim Nashwan , H Musa Dildar , S M. Saleem Zana 
Published: September 2022

Objectives: The aim of this cross-sectional study is to evaluate the seroprevalence of total antibodies to SARS-CoV-2 and associated risk factors in Zakho City, Kurdistan Region of Iraq.
Methods: This cross-sectional study was performed at Zako City, Northern, Iraq. Blood samples were collected from different districts of Zakho city between January and March 2021. Immunoassays were performed to detect the total antibodies against SARS-CoV-2, and the associations between several variables were investigated.
Results: A total of 315 participants were agreed and enrolled in the study. The average age of the participants was 32.87±13.25 years. Among the participants, 214/315 (67.93%) were found to have antibodies against SARS-CoV-2. Among those who had positive antibodies, 169/214 (78.97%) were asymptomatic and 45/214 (21.03%) had a history of COVID-19 related symptoms. The most common symptom was fever (95.56%), followed by loss of smell (84.44%) and myalgia (80.0%). We found that antibody levels significantly associated with age (P=0.021). The presence of symptoms was significantly higher among subjects with a history of comorbidity diseases (P=0.038), and older people (P = 0.015). A significant association was found between antibody levels and the marital status (P=0.014), chronic diseases (P=0.001), presence (P=0.015) and duration of symptoms (P=0.028).
Conclusion: A significant association between antibody levels to SARS-CoV-2 and age, chronic diseases, presence and duration of symptoms were found in this study. Seroprevalence studies of antibodies to SARS-CoV-2 among general population are of utmost importance to develop infection prevention programs in our society.
Mirada caleidoscópica a los cuentos “una felicidad repulsiva” y “una madre protectora”
Authors: Valencia Gómez María Rosa 
Published: September 2022

Desde tiempo antiguos, el hombre a través del aforismo griego “Conócete a ti mismo” ha iniciado una búsqueda que parece no tener fin, desde este precepto la sociedad es una variante para determinar la falta de: esencia, libertar, empatía y demás elementos que por medio de la literatura son explorados. La humanidad desde su génesis no ha dejado de “relatar” ese verbo tan corto pero conciso, devela la compleja necesidad de expresar a través de las letras experiencias vividas.

Es este sentido, se trae a colación dos cuentos que hacen parte del libro Una felicidad repulsiva, escrito por el Argentino Guillermo Martínez, uno de ellos alude al título de la obra y es la pieza inicial, una historia con matices variados los cuales sumergen al lector en un juego metaficcional, donde la felicidad es el eje temático y sus personajes giran alrededor de esa sensación, que todo sujeto desea obtener. De esta manera, Martínez abre la puerta a secretos familiares, pugnas clasistas y grietas emocionales, que hacen parte de la naturaleza del hombre.
Así mismo, se retoma la historia “Una madre protectora”, con el que se da por concluido el libro, donde el personaje principal traspasa los límites de la maternidad desde un interés desmedido por el hijo, fascinación que emerge en el vientre y continua de manera exagerada con el nacimiento y posteriores etapas de desarrollo. Se puede juzgar las actitudes de ella o más bien compaginar con el amor enfermizo, de esta forma la mujer encarnar el prototipo de madre perfecta que desea hacer lo imaginable para que su hijo este a salvo y aunque son perturbadoras las acciones que realiza, es probable que una madre como dice el título “protectora” justifiqué el actuar del personaje.
El lector entonces, lograr sentirse identificado con el simbolismo de la maternidad en todo su esplendor, esa que ama, cuida, protege, alimenta, vela, enseña y sobre todo no se equivoca... Al parecer una maternidad idealizada, casi sublime. En este orden de ideas, los dos cuentos son un entramado de historias que ejemplifican la crudeza del sujeto ante la vida y sus atormentadas realidades.
Ruta de innovación social en un grupo de estudiantes del programa de administración de empresas de la Corporación Universitaria Minuto de Dios - UNIMINUTO en el municipio de Ibagué
Authors: Andrade Restrepo Lina María , Rico Otalora Byron Armando , Gómez Bonilla Laura Rita 
Published: September 2022

El presente artículo muestra la implementación de la ruta de la innovación social, metodología creada por el parque científico de innovación social PCIS, ruta que, aborda problemáticas, que intentan solucionarse, mediante la participación de diferentes actores y recursos. El objetivo principal de la investigación fue desarrollar e implementar la metodología para la ejecución de la ruta de innovación social en el curso análisis y diagnóstico organizacional del programa de Administración de Empresas (AEMD) de la Vicerrectoría del Tolima y Magdaleno Medio (VTMM) Corporación Universitaria Minuto de Dios – Uniminuto en el municipio de Ibagué. La metodología utilizada en la investigación fue cualitativa, se recurrió también a el método de investigación acción contando con la participación del docente que orienta el curso y los estudiantes. Como resultados principales se encontró que los estudiantes pudieron aplicar los conocimientos vistos en el curso en un entorno real. Asimismo, ellos lograron generar mayores habilidades organizativas, resultado de la interacción con los tenderos y el funcionamiento de sus tiendas. Por otro lado, Los tenderos de la comuna 6 evidenciaron algunas falencias en el desarrollo de las actividades que realizaban en sus tiendas.
Análisis de la implementación de una Política Pública Educativa utilizando la herramienta Atlas Ti
Authors: Velandia Moncada Nancy Yamile 
Published: September 2022

Una política pública se genera de la necesidad de modificar una situación problema identificada en una sociedad, por medio de acciones tomadas desde un ente gubernamental (Deubel, 2002) en Colombia en el año 2015 se planteó la Política de Día de la Excelencia como respuesta a la necesidad de mejorar los resultados académicos y alcanzar el objetivo de otra política que se propuso en este mismo año “Colombia la mejor educada en el 2025”. La investigación a nivel general busca identificar aspectos relevantes en la implementación de la política “Día E” mediante el análisis de los aspectos institucionales que convergen en el mejoramiento de la calidad educativa por medio de un estudio de caso en las instituciones educativas públicas de Zipaquirá, Colombia. El propósito del artículo es ofrecer una propuesta para el análisis de un documento institucional que se denomina Sistema Institucional de Evaluación de los Estudiantes SIEE (Ministerio de Educación Nacional de Colombia, 2009), que hace parte de las acciones que se desarrollan dentro de los centros educativos y que son objeto de evaluación en el Día de la Excelencia, se presenta entonces como recurso metodológico el programa de Atlas Ti para el análisis documental. En cuanto a la metodología se tiene una primera etapa que consistió en la recopilación del documento SIEE de cada uno de los 10 centros educativos del municipio de Zipaquirá, luego el investigador asumió la responsabilidad de realizar una codificación de acuerdo con un sistema categorial propuesto y previamente validado, posteriormente se hace una interpretación semántica del texto y por último se presentan unos resultados y conclusiones corroborados con la fundamentación teórica. En cuanto a los resultados más relevantes se identificaron los conceptos claves que deben ser presentados en los documentos SIEE, para que tengan una validez y sean realmente los derroteros que permitan mejorar la calidad eductaiva desde los actores institucionales, se determinan también acciones de mejora que se deben implementar desde los documentos y se concluyen cuáles son las categorías que se deben trabajar desde los SIEE para la implementación de las propuestas del Día E.