bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technology Focus: History Matching and Forecasting (April 2022)
Authors: Carpenter Chris 
Published: May 2022

This year’s history matching and forecasting selections, made by reviewer Gopi Nalla of DeGolyer and MacNaughton, reflect the importance of accurate and innovative methodology in the approach toward development of unconventional or challenging plays, from tight oil to highly heterogeneous gas fields to coalbed methane.
The authors of paper URTEC 208352 evaluate and compare the performance of rate-normalization and pressure-deconvolution techniques for both synthetic and tight-oil examples. While the synopsis is devoted mostly to the authors’ work in applying these techniques to synthetic cases, much of the complete paper is devoted to tight-oil examples. Ultimately, the authors recommend the pressure-deconvolution approach generally.
In paper SPE 207933, the authors apply an integrated approach of using reservoir pressure/gas compressibility (P/Z) calculations to obtain a field gas initially in place (FGIIP) estimation that is then incorporated into an integrated asset model. The technique is applied to a giant onshore gas field. The authors conclude that the new FGIIP estimation can be applied as a reference to re-review the static modeling legacy and to narrow static modeling uncertainties, leading to reliable forecasting and more-efficient field development.
An application of the iterative ensemble Kalman smoother to a scenario involving horizontal coalbed-methane wells for a low-permeability field in Australia is the subject of paper URTEC 208291. A forecast study was conducted to validate the history-matched ensemble, with the results showing a good match of 12 months of the new production data not used in history matching, highlighting the robust prediction capabilities of the presented approach.
SPE papers continue to a be a vital resource for industry professionals; arguably, such work is more important than ever as the industry and the world adjusts to new modes of collaboration and realities in both the office and the field. I invite you to read the full text of these papers on OnePetro and to find further recent works that advance the literature of this specialized but critical Tech Focus topic.
Recommended additional reading at OnePetro: www.onepetro.org.
URTEC 208361 - Effect of Relative Permeability on Modeling of Shale Oil and Gas Production by Hamid Behmanesh, University of Calgary, et al.
SPE 204835 - Successful Case Study of Machine-Learning Application To Streamline and Improve History-Matching Process for Complex Gas-Condensate Reservoirs in Hai Thach Field, Offshore Vietnam by Son Hoang, Bien Dong Petroleum Operating Company, et al.
SPE 207855 - Unleashing the Potential of Relative Permeability Using Artificial Intelligence by Abdur Rahman Shah, Schlumberger, et al.
Comparison of two surgical approaches for acute type A aortic dissection: Hybrid Debranching Versus Total Arch Replacement
Authors: Huang Feng , Li Xiaofeng , Zhang Zili , Li Chunping , Ren Fei 
Published: May 2022

Abstract
Background
The goal of this study was to determine the clinical outcomes of total arch replacement with frozen elephant trunk surgery and hybrid debranching surgery for acute type A aortic dissection patients.
Methods
From January 2017 to December 2019, the clinical data of acute type A aortic dissection patients were retrospectively collected and analyzed. There were 142 patients underwent total arch replacement with frozen elephant trunk surgery and 35 patients underwent hybrid debranching surgery.
Result
The age, the body mass index and the renal insufficiency of patients in the hybrid group were higher than those in the total arch replacement (TAR) group (all P<0.01). The operation time, the cardiopulmonary bypass time and the aortic occlusion time of patients in the TAR group were significantly longer than those in the hybrid group (all P<0.01). Patients in the debranching group had shorter ventilator-assisted breathing time, shorter postoperative hospital stay time and shorter intensive care unit (ICU) stay time. The incidence of pulmonary infection and transient neurological dysfunction were lower, and the transfusions of red blood cells and plasma during the perioperative period were smaller. The survival rates at 2 years were 91.9% and 85.9% in the TAR and hybrid groups, respectively.
Conclusion
Hybrid debranching operation is a safe and effective method for acute type A aortic dissection. Compared with TAR surgery, hybrid debranching surgery has the characteristics of less trauma, rapid recovery and lower incidence of complication.
Spatial Analysis of Malaria Hotspots in Dilla Sub-Watershed: Western Ethiopia
Authors: Ofgeha Gemechu Y. 
Published: May 2022

Abstract
The study was aimed to examine the spatial variations in malaria hotspots along Dilla sub-watershed in western Ethiopia based on environmental factors for the incidences; and compare risk level among districts and their respective kebeles. Ethiopian Central Statistical Agency based meteorological data, digital elevation model, soil and hydrological data were used. Different spatial analysis tools and Software were used for watershed delineation, generating malaria risk map for all variables, reclassification of factors, weighted overlay analysis and generation of risk maps. The findings of the study reveal that all districts and kebeles have different level of malaria risk due to variation in their environmental conditions. Accordingly, significant areas in Guliso, Aira, Boji Chokorsa, Boji Dirmaji, Jarso, Najo, Gawo Kebe, and Dale Wabera are characterized as high and moderately exposed to malaria risk. More specifically, about 14 kebeles of Aira, 12 kebeles of Guliso, 8 kebeles of Jarso, 8 kebeles of Najo, 4 kebeles of Boji Chokorsa, 4 kebeles of Boji Birmaji were highly and moderately exposed to the risk. In general, out of the total area of the watershed which accounts 2773 km2, about 54.8% (1522km2) identified as high and moderate malaria risk area. The research output may help the government and humanitarian organizations to prioritize the interventions based on identified spatial variations in malaria severity. The research is aimed only for hotspot analysis which may not provide comprehensive account for community’s vulnerability to malaria. Thus, this research finding needs to be integrated with the socio-economic and other data for better malaria management in the area.
Data analysis and research reveal the reasons why China still adheres to its “dynamic zero-COVID policy”
Authors: Dai Yeyu , Dai Bingxi 
Published: May 2022

Abstract
A complete and accurate statistical analysis of cases of contraction with SARS-CoV-2 are given under the conditions of strict mandatory quarantine and isolation and of a high rate of full vaccination. SARS-CoV-2 is still new, and little is known about either its direction of variation or its propagation laws. China has been attacked by its largest outbreaks of COVID-19 since March. Pervasive arguments arose among people in China and around the world. Here we reveal the essential reasons why China has been and will be adhering to its “dynamic zero-COVID policy” which stands in contrast to a global trend towards easing restrictions and attempting to co-exist with the circulating virus, including the choice uniqueness, morbidity differences in different cities, unpredictability, worries of sudden impact to medical system, successful reducing to zero the number of each active chain of transmission and outstanding economy achievements, etc. This study provides first-hand valuable information for further research on similar epidemics in the future. It may bring new thoughts for correction of present epidemiological theory and mathematical models, as well as new theoretical supports for the prevention policy making. It may also give other countries time to be better prepared for the coming 6th wave driven by Omicron BA.2.
Construction of a P–N–Si flame retardant coating on the cotton fabric with the integration of biomass carbon dots and ammonium polyphosphate
Authors: Xue Baoxia , Shi Yiran , Zhang Chunyan , Niu Mei , Yang Yongzhen 
Published: May 2022

Abstract
In order to improve the flame retardant performance of cotton fabric, a kind of biomass carbon dots (CDs) particles were interspersed in the ammonium polyphosphate (APP) layer to achieve a new efficient CDs-based APP (CDs-APP) composite flame retardant by the integration technology. Then the CDs-APP layer was coated on the surface of cotton fabric. The microstructure and thermal stability of CDs-APP particle were characterized by the Transmission electron microscopy (TEM), Fourier infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The mass ratio of CDs to APP was 15.52%, which contains the C, O, N, Si and P elements, accounting for the 28.86%, 42.29%, 19.01%, 2.58% and 6.26%, respectively. The flame retardant mechanism of CDs-APP was investigated by the limiting oxygen index (LOI), vertical combustion, cone calorimetry (CONE), thermogravimetric and thermogravimetric-infrared analysis. The results showed that, when the content of CDs-APP was about 10%, the LOI value of cotton fabric rose to 36.1%. The burning time and damage length have reduced to 4.5 s, 5.6 cm, respectively. And the fabric achieved B1 level. The addition of CDs-APP decreased the total heat release, heat release rate, total smoke emission and smoke emission rate of cotton fabric, among the peak-heat release rate has decreased by 55.78%. By quantifying the flame retardant modes of CDs-APP, it displayed the superposition of physical barrier effect, flame inhibition effect and catalytic charring effect, accounting for 45.96%, 8.62% and 47.85%, respectively.
Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals
Authors: Hong Yun Jeong , Kim Chanmi , Lee Jae Hong , Sepulcre Jorge 
Published: May 2022

Abstract
Background:
The correlations between apolipoprotein epsilon 4 (APOE4) status and regional amyloid, tau, and cortical thickness in cognitively normal elderly are not fully understood. Our cross-sectional study aimed to compare regional amyloid/tau burden, and cortical thickness according to APOE4 carrier status and assess correlations between APOE4 and Alzheimer’s disease (AD)-related biomarker burdens.
Methods:
We analyzed 185 cognitively normal participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. Participants aged 55–90 with normal cognitive function were divided into amyloid ꞵ-positive (Aß+) APOE4 carriers (group 1, n = 27), Aß+ APOE4 non-carriers (group 2, n = 29), and Aß- normal controls (group 0, n = 129). We compared amyloid depositions, tau depositions, and cortical thickness among the 3 groups and assessed correlations between APOE4 existence and imaging biomarkers adjusted for age and sex.
Results:
The participants in group 2 were older than those in the other groups. The regional amyloid/tau standardized uptake value ratios (SUVRs) did not differ between groups 1 and 2, but the amyloid/tau SUVRs in most regions were numerically higher (especially in the younger (< 70) participants) in group 1 than group 2 after adjusting for age difference. APOE4 allele had robust correlations with increased amyloid burden in the fronto-temporo-parietal cortical areas after adjustment for age and sex, but it had weaker and mixed correlations with the regional tau burden and did not have significant correlation with cortical thickness.
Conclusions:
We identified that the presence of APOE4 allele might be more highly associated with amyloid deposition than with other AD-related biomarkers such as tau or cortical thickness, especially in the younger group below 70 in cognitively normal elderly.
Arylamine N-acetyltransferase 1 deficiency inhibits drug-induced cell death in breast cancer cells: switch from cytochrome C-dependent apoptosis to necroptosis.
Authors: McAleese Courtney , Butcher Neville , Minchin Rod 
Published: May 2022

Abstract
Purpose Arylamine N-acetyltransferase 1 (NAT1) deficiency has been associated with drug resistance and poor outcomes in breast cancer patients. The current study aimed to investigate drug resistance in vitro using normal breast cancer cell lines and NAT1 deficient cell lines to understand the changes induced by the lack of NAT1 that resulted in poor drug response. Methods The response to seven chemotherapeutic agents was quantified following NAT1 deletion using CRISPR-Cas 9 in MDA-MB-231 and T-47D cells. Apoptosis was monitored by annexin V staining and caspase 3/7 activity. Cytochrome C release and caspase 8 and 9 activities were measured by Western blots. Caspase 8 was inhibited using Z-IETD-FMK and necroptosis was inhibited using necrostatin and necrosulfonamide.Results Compared to parental cells, NAT1 deficient cells were resistant to drug treatment. This could be reversed following NAT1 rescue of the NAT1 deleted cells. Release of cytochrome C in response to treatment was decreased in the NAT1 deficient cells, suggesting suppression of the intrinsic apoptotic pathway. In addition, NAT1 knockout resulted in a decrease in caspase 8 activation. Treatment with necrosulfonamide showed that NAT1 deficient cells switched from intrinsic apoptosis to necroptosis when treated with the anti-cancer drug cisplatin. Conclusions NAT1 deficiency can switch cell death from apoptosis to necroptosis resulting in decreased response to cytotoxic drugs. The absence of NAT1 in patient tumours may be a useful biomarker for selecting alternative treatments in a subset of breast cancer patients.
Association of rs12979860 and rs8099917 polymorphisms at IL28B gene with chronic hepatitis B and C, and non-viral liver disease patients IL28B rs8099917 G risk factor for hepatitis B patients
Authors: ÇAKAL BÜLENT , ÇAVUŞ BİLGER , Atasoy Alp , Altunok Damla , Poda Mehveş , Bulakçı Mesut , Güllüoğlu Mine , Demirci MEHMET , Şener Leyla Türker , Arslan Aslı Berru , Akyüz Filiz 
Published: May 2022

Abstract
The authors have requested that this preprint be removed from Research Square.
Ensemble genetic machine learning identifies Multiple Sclerosis genetic loci associated with future worsening of disability
Authors: Fuh-Ngwa Valery , Zhou Yuan , Melton Phillip E. , Mei Ingrid van der , Charlesworth Jac C. , Lin Xin , Zarghami Amin , Broadley Simon A. , Ponsonby Anne-Louise , Simpson-Yap Steve , Lechner-Scott Jeannette , Taylor Bruce V. 
Published: May 2022

Abstract
Limited studies have been conducted to identify and validate multiple sclerosis (MS) genetic loci associated with disability progression. We aimed to identify MS genetic loci associated with worsening of disability over time, and to develop and validate ensemble genetic learning model(s) to identify people with MS (PwMS) at risk of future worsening. We examined associations of 208 previously established MS genetic loci with the risk of worsening of disability; we learned ensemble genetic decision rules and validated the predictions in an external dataset. We found 7 genetic loci (rs7731626: HR = 0.92, P = 2.4x10− 5; rs12211604: HR = 1.16, P = 3.2x10− 7; rs55858457: HR = 0.93, P = 3.7x10− 7; rs10271373: HR = 0.90, P = 1.1x10− 7; rs11256593: HR = 1.13, P = 5.1x10− 57; rs12588969: HR = 1.10, P = 2.1x10− 10; rs1465697: HR = 1.09, P = 1.7x10− 128) associated with worsening of disability; most of which are located near or tagged to 13 genomic regions enriched in peptide hormones and steroids biosynthesis pathways by positional and eQTL mapping. The derived ensembles provided a set of genetic decision rules that can be translated to provide additional prognostic values to existing clinical predictions, with the additional benefit of incorporating relevant genetic information into clinical decision making for PwMS. The present study extends our knowledge of MS progression genetics and provides the basis of future studies regarding the functional significance of the identified loci.
Presynchronization with simultaneous administration of GnRH and PGF2α 7 days prior to Ovsynch improves reproductive profile in Hariana zebu cow
Authors: Saini Gitesh , Kumar Sandeep , Pandey Anand Kumar , Singh Harender , Virmani Meenakshi 
Published: May 2022

Abstract
This study aimed to assess the impact of simultaneous administration of GnRH and PGF2α 7 days prior to Ovsynch in Hariana cow. Two hundred cyclic cows (> 4 months postpartum) were assigned to Control (n = 54) and Pre-OV (n = 146). As per Ovsynch protocol, Buserelin acetate (10µg), Cloprostenol (500µg) and Buserelin acetate (10µg) were injected i.m. on day 0, 7 and 9, respectively in cows irrespective of treatment. But in Pre-OV cows, Buserelin acetate (10µg) and Cloprostenol (500µg) were also injected i.m. simultaneously 7 days prior to initiate Ovsynch protocol. Artificial insemination was performed between 18–24 hours after 2nd GnRH of Ovsynch in the both treatments. Ultrasonography and blood sampling for hormonal analysis was done on each day of treatment, on day of AI and 12 days post-AI. Pre-OV treatment resulted to increased (45.20% vs 29.62%; P < 0.05) pregnancy outcomes, higher (P < 0.01) ovulation rate to first GnRH of Ovsynch than control. Cows showing complete luteolysis in response to PGF2α of Ovsynch were also higher (P < 0.05) in Pre-OV than control. Greater (P < 0.05) synchronization rate was recorded in Pre-OV than control (86.76% and 68.75%). The circulating conc. of estradiol on day of AI and progesterone on day 12 post-AI were higher (P < 0.01) in cows diagnosed pregnant than non-pregnant in both control and Pre-OV treatment. In conclusion, simultaneous administration of GnRH and PGF2α 7 days before Ovsynch improved the synchronization rate, luteal profile in terms of CL area and hence resulted in higher conception rate in Hariana zebu cow.
Would you own a ROBOT? : A detailed research on public response to the nooks and crannies of owning a robot.
Authors: Dahal Ashim 
Published: May 2022

Abstract
The utility aspects of robots in our day to day tasks have been diminished over the fear ofthem taking over humanity, especially thanks to unrealistic movies. But how much shouldthe public care about having or owning a robot? What tasks do we want robots to do?Which workforce do we want a robot to join? What are the privacy concerns of owning arobot? And given the circumstances of an economy sustained by our automated metalfriends, will we still want to continue our jobs? In this research, we find answers to all thesequestions.
Cortical atrophy is associated with cognitive impairment in Parkinson's disease: a combined analysis of cortical thickness and functional connectivity
Authors: Zhu Yongyun , Yang Baiyuan , Zhou Chuanbin , Gao Chao , Hu Yanfei , Yin Weifang Fang , Yin kangfu , Zhu Yangfan , Jiang Guoliang , Ren Hui , Pang Ailan , Yang Xinglong 
Published: May 2022

Abstract
We aimed to perform a combined analysis of cortical thickness and functional connectivity to explore their association with cognitive impairment in Parkinson's disease (PD). A total of 53 PD and 15 healthy control subjects were enrolled. PD patients were divided into PD with normal cognition (PD-NC, n = 25), PD with mild cognitive impairment (PD-MCI, n = 11), and PD with dementia (PDD, n = 17). Cognitive status was assessed with the Mini-Mental State Examination (MMSE). Anatomical magnetic resonance imaging and resting-state functional connectivity analysis were performed in all subjects. First, surface-based morphometry measurements of cortical thickness and voxels with cortical thickness reduction were detected. Then, regions showing reduced thickness were analyzed for changes in resting-state functional connectivity in PD involving cognitive impairment (PD-MCI and PDD groups together). Our results showed that, compared with PD-NC, patients with cognitive impairment showed decreased cortical thickness in the left superior temporal, left lingual, right insula, and right fusiform regions. PD-MCI patients showed these alterations in the right lingual region. Widespread cortical thinning was detected in PDD subjects, including the left superior temporal, left fusiform, right insula, and right fusiform areas. We found that cortical thinning in the left superior temporal, left fusiform, and right temporal pole regions positively correlated with MMSE score. In the resting-state functional connectivity analysis, we found a decrease in functional connectivity between the cortical atrophic brain areas mentioned above and cognition-related brain networks, as well as an increase in functional connectivity between those region and the cerebellum. Alterations in cortical thickness may result in a dysfunction of resting-state functional connectivity, contributing to cognitive decline in patients with PD.
Efficacy of treatment with N-acetylcysteine inhalation for AECOPD: A propensity-score-matched cohort study
Authors: Chen Hengyi , Zhou Hui , Luo Chen , Zong Kaican , Fu Yingya , Li Wen , Luo Chunyan , Xue Guojuan , Jiang E , Duan Yang , Luo Tinglan , Jiang Yangzhi 
Published: May 2022

Abstract
Background: N-acetylcysteine (NAC) prevents acute exacerbations of chronic obstructive pulmonary disease (AECOPD). However, the value of N-acetylcysteine (NAC) inhalation in the treatment of an AECOPD requiring hospitalization still remains unclear. The present study was designed to evaluate the clinical efficacy of NAC inhalation in patients with AECOPD requiring hospitalisation. Methods: In this single-center, retrospective cohort study, all patients with AECOPD requiring hospitalisation between October 2016 and October 2021 were included. The primary outcome was the length of hospital stay. The change in the spirometric parameter, including the post-bronchodilator forced expiratory volume in one second (FEV 1), forced vital capacity (FVC), forced expired flow at 50% of vital capacity (FEF 50%), mean forced expiratory flow between 25% and 75% of vital capacity (FEF 25-75%), residual volume/total lung capacity (RV/TLC), and arterial blood gas tensions over the first 7 days of the admission, the incidence of adverse events (AEs) were calculated to estimate the differences between the two groups. Results: A total of 1257 patients were enrolled in this study. Of these, 202 propensity score–matched patients (101 in the NAC group and 101 in the Non-NAC group) were included in the final analyses. The mean length of hospital stay was 8.4 days (95% CI 7.6 to 8.4) days for the NAC group and 9.2 days (95% CI 8.6 to 9.4) for the Non-NAC group (p = 0.044). The improvement rates in partial arterial oxygen pressure (PaO2), partial pressure of carbon dioxide (PaCO2) and spirometric parameter, including FEV 1, FVC, FEF 50%, FEF 25-75%, and RV/TLC were significantly higher in NAC group than in Non-NAC group. No differences between groups were observed in adverse effects, self-reported symptomatic improvement from admision to day 5, mechanical ventilation rates during hospitalization, exacerbation and rehospitalisation rates within one month of discharge.Conclusion：NAC inhalation can markedly shorten the length of hospital day, improve pulmonary function, raise PaO2 and decrease PaCO2 in patients with AECOPD requiring hospitalization, which may be a safe and effective supplementary treatment in AECOPD patients.