bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a dynamic and sustainable management of geological resources
Authors: Compernolle Tine , Eswaran Adithya , Welkenhuysen Kris , Hermans Thomas , Walraevens Kristine , van Camp Marc , Buyle Matthias , Audenaert Amaryllis , Bleys Brent , van Schoubroeck Sophie , Bergmans Anne , Goderniaux Pascal , Baele Jean-Marc , Kaufmann Olivier , Vardon Phil J. , Daniilidis Alex , Orban Philippe , Dassargues Alain , Serge Brouyère , Piessens Kris 
Published: September 2022

Abstract
The subsurface provides multiple resources, the exploitation of which has a lasting impact on future potential provision. Establishing sustainability in terms of fundamental principles, and fitting these principles into a practical framework, is an ongoing endeavour focused mainly on surface activities. The principles of ecological economics lead to six challenges that summarize the current limitations of implementing science-based sustainable management of geological resources in the medium to deep subsurface: integrating value pluralism, defining sustainable scale, evaluating interferences in the subsurface, guaranteeing environmental justice, optimizing environmental and economic efficiency and handling uncertainties. Assessing and managing geological reservoirs is particularly challenging because of slow resource regeneration, complex spatial and temporal interactions, concealment and naturally dictated opportunities. In answer to the challenges, visions are proposed that outline how an indicator framework is needed for guidance, how indicators require reservoir models with extended spatial and temporal scope, how differences in social values in relation to the environment are to be considered and how real option games combined with life cycle assessment can be used for optimizing efficiency. These individual solutions relate to different facets of the same problem, and can be integrated into one overarching solution that takes the form of dynamic multi-criteria decision analysis.
Theoretical and Empirical Analysis of Parameter Control Mechanisms in the (1 + (λ, λ)) Genetic Algorithm
Authors: Hevia Fajardo Mario Alejandro , Sudholt Dirk 
Published: September 2022

The self-adjusting (1 + (λ, λ)) GA is the best known genetic algorithm for problems with a good fitness-distance correlation as in
OneMax
. It uses a parameter control mechanism for the parameter λ that governs the mutation strength and the number of offspring. However, on multimodal problems, the parameter control mechanism tends to increase λ uncontrollably.

We study this problem for the standard
Jump

k

benchmark problem class using runtime analysis. The self-adjusting (1 + (λ, λ)) GA behaves like a (1 +
n
) EA whenever the maximum value for λ is reached. This is ineffective for problems where large jumps are required. Capping λ at smaller values is beneficial for such problems. Finally, resetting λ to 1 allows the parameter to cycle through the parameter space. We show that resets are effective for all
Jump

k

problems: the self-adjusting (1 + (λ, λ)) GA performs as well as the (1 + 1) EA with the optimal mutation rate and evolutionary algorithms with heavy-tailed mutation, apart from a small polynomial overhead.

Along the way, we present new general methods for translating existing runtime bounds from the (1 + 1) EA to the self-adjusting (1 + (λ, λ)) GA. We also show that the algorithm presents a bimodal parameter landscape with respect to λ on
Jump

k

. For appropriate
n
and
k
, the landscape features a local optimum in a wide basin of attraction and a global optimum in a narrow basin of attraction. To our knowledge this is the first proof of a bimodal parameter landscape for the runtime of an evolutionary algorithm on a multimodal problem.
Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis
Authors: SanMiguel Jennifer M. , Eudy Elizabeth , Loberg Matthew A. , Young Kira A. , Mistry Jayna J. , Mujica Kristina D. , Schwartz Logan S. , Stearns Timothy M. , Challen Grant A. , Trowbridge Jennifer J. 
Published: September 2022

Abstract

Clonal hematopoiesis resulting from the enhanced fitness of mutant hematopoietic stem cells (HSC) associates with both favorable and unfavorable health outcomes related to the types of mature mutant blood cells produced, but how this lineage output is regulated is unclear. Using a mouse model of a clonal hematopoiesis–associated mutation, DNMT3AR882/+ (Dnmt3aR878H/+), we found that aging-induced TNFα signaling promoted the selective advantage of mutant HSCs and stimulated the production of mutant B lymphoid cells. The genetic loss of the TNFα receptor TNFR1 ablated the selective advantage of mutant HSCs without altering their lineage output, whereas the loss of TNFR2 resulted in the overproduction of mutant myeloid cells without altering HSC fitness. These results nominate TNFR1 as a target to reduce clonal hematopoiesis and the risk of associated diseases and support a model in which clone size and mature blood lineage production can be independently controlled to modulate favorable and unfavorable clonal hematopoiesis outcomes.

Significance:
Through the identification and dissection of TNFα signaling as a key driver of murine Dnmt3a-mutant hematopoiesis, we report the discovery that clone size and production of specific mature blood cell types can be independently regulated.
See related commentary by Niño and Pietras, p. 2724.
This article is highlighted in the In This Issue feature, p. 2711
DDR2 Coordinates EMT and Metabolic Reprogramming as a Shared Effector of FOXQ1 and SNAI1
Authors: Mitchell Allison V. , Wu Jason , Meng Fanyan , Dong Lun , Block C. James , Song Won-min , Zhang Bin , Li Jing , Wu Guojun 
Published: September 2022

While multiple transcription factors (TF) have been recognized to drive epithelial–mesenchymal transition (EMT) in cancer, their interdependence and context-dependent functions are poorly understood. In this study, we show that FOXQ1 and SNAI1 act as independent TFs within the EMT program with a shared ability to upregulate common EMT-TFs without reciprocally impacting the expression of one another. Despite this independence, human mammary epithelial cells with ectopic expression of either FOXQ1 or SNAI1 share a common gene set that is enriched for a DDR2 coexpression signature. Further analysis identified DDR2 as the most upregulated receptor tyrosine kinase and a shared downstream effector of FOXQ1 and SNAI1 in triple-negative breast cancer (TNBC) cell lines. Alteration of DDR2 expression in either FOXQ1- or SNAI1-driven EMT models or in TNBC cells resulted in a profound change of cell motility without significantly impacting EMT marker expression, cell morphology, or the stem cell population. Finally, we demonstrated that knockdown of DDR2 in the FOXQ1-driven EMT model and TNBC cell line significantly altered the global metabolic profile, including glutamine-glutamate and aspartic acid recycling.Significance:The critical role of DDR2 in cancer metastasis has been well established. However, the exact function of DDR2 in driving cancer metastatic progression remains unclear. The results of our current study provide new insights into the cancer-driving function of DDR2, suggesting that DDR2, as a shared effector of the EMT program, may drive tumor progression by promoting breast cancer cell motility and metabolic reprogramming.
Heidegger’s Conversational Pedagogy
Authors: Davies Katherine 
Published: September 2022

Abstract
Between 1944 and 1954, Heidegger wrote five dialogues – or conversations – that stage philosophical discussions. I argue these texts develop a yet unacknowledged Heideggerian pedagogy of conversation. From the characters he conjures to the topics of their discussions, Heidegger underscores the importance of teaching and learning differently in each conversation and shapes his own pedagogical sensibility. Each text uniquely elaborates a particular element of his pedagogy, including the importance of attending to attunement, making mistakes, coming together in community, poetic interpretation, and the dangers of conversational language itself. Only in reading the conversations together does Heidegger’s conversational pedagogy emerge. Above all, the teacher must resist assuming an authoritative role with her students; the Heideggerian teacher must learn to silently gesture toward the locale of the question-worthy by preserving its alterity.
Tropical Africa’s First Testbed for High-Impact Weather Forecasting and Nowcasting
Authors: Fletcher J. K. , Diop C. A. , Adefisan E. , Ahiataku M. A. , Ansah S. O. , Birch C. E. , Burns H. L. , Clarke S. J. , Gacheru J. , James T. D. , Tuikong C. K. Ngetich , Koros D. , Indasi V. S. , Lamptey B. L. , Lawal K. A. , Parker D. J. , Roberts A. J. , Stein T. H. M. , Visman E. , Warner J. , Woodhams B. J. , Youds L. H. , Ajayi V. O. , Bosire E. N. , Cafaro C. , Camara C. A. T. , Chanzu B. , Dione C. , Gitau W. , Groves D. , Groves J. , Hill P. G. , Ishiyaku I. , Klein C. M. , Marsham J. H. , Mutai B. K. , Ndiaye P. N. , Osei M. , Popoola T. I. , Talib J. , Taylor C. M. , Walker D. 
Published: September 2022

Abstract
Testbeds have become integral to advancing the transfer of knowledge and capabilities from research to operational weather forecasting in many parts of the world. The first high-impact weather testbed in tropical Africa was recently carried out through the African Science for Weather Information and Forecasting Techniques (SWIFT) program, with participation from researchers and forecasters from Senegal, Ghana, Nigeria, Kenya, the United Kingdom, and international and pan-African organizations. The testbed aims were to trial new forecasting and nowcasting products with operational forecasters, to inform future research, and to act as a template for future testbeds in the tropics. The African SWIFT testbed integrated users and researchers throughout the process to facilitate development of impact-based forecasting methods and new research ideas driven both by operations and user input. The new products are primarily satellite-based nowcasting systems and ensemble forecasts at global and regional convection-permitting scales. Neither of these was used operationally in the participating African countries prior to the testbed. The testbed received constructive, positive feedback via intense user interaction including fishery, agriculture, aviation, and electricity sectors. After the testbed, a final set of recommended standard operating procedures for satellite-based nowcasting in tropical Africa have been produced. The testbed brought the attention of funding agencies and organizational directors to the immediate benefit of improved forecasts. Delivering the testbed strengthened the partnership between each country’s participating university and weather forecasting agency and internationally, which is key to ensuring the longevity of the testbed outcomes.
Synthesis and properties of biobased non-isocyanate aliphatic thermoplastic polyurethane elastomers with butanediurethane hard segments
Authors: Qin Yao , Yuan Xiaokai , Sang Zhihui , Zhang Zhiyuan , Zhao Jingbo , Zhang Junying 
Published: September 2022

A simple non-isocyanate route is established to synthesize biobased aliphatic thermoplastic polyurethane elastomers (TPEUs) with excellent mechanical properties. Melt transurethane co-polycondensation of bis(hydroxyethyl) butanediurethane (BHBDU) with different polycaprolactone-diols (PCDLs) was conducted at 170°C under a reduced pressure of 3 mmHg, and a series of TPEUs were prepared. The TPEUs were characterized by gel permeation chromatography, FT-IR, 1H-NMR, wide angle X-ray scattering, DSC, TGA, dynamic mechanical analysis, atomic force microscopy, and tensile test. TPUEs exhibited Mn above 25,000 g/mol, Tg of −36 to 1°C, Tm up to 105°C, maximal tensile strength of 38 MPa with a strain at break of 926%, and resilience of 80%–90%. BHBDU and PCDLs may be synthesized from bioresources. Biobased aliphatic TPU elastomers with excellent tensile strength and resilience were prepared successfully through a non-isocyanate route.
Numerical investigation of fire in the cavity of naturally ventilated double skin façade with venetian blinds
Authors: Huang Youxian , Yeboah Siegfried , Shao Jingjing 
Published: September 2022

Double skin façades (DSFs), offer great views, architectural aesthetics, and energy savings. Yet, in a fire event the glass façade breaks leading to risks to human life and firefighting difficulties. Shading devices incorporated to prevent unfavourable heat gains to reduce cooling load though offer energy savings potentially present other challenges in firefighting and occupants’ evacuation. In this study, Fire Dynamic Simulator (FDS) was used to numerically investigate the spread of a 5 MW HRR polyurethane GM27 fire in a multi-storey double skin façade building with Venetian blinds placed in its cavity. The blinds were positioned 0.4 m away from the internal glazing, middle of the cavity and 0.4 m away from the external glazing respectively. In each blind position the slat angle was opened at 0°, 45°, 90° and 135° respectively. The results show peak inner glazing surface temperature ranged between 283°C to 840°C depending on the thermocouple position, the Venetian blind position and slat opening angle. Without Venetian blinds, peak inner glazing surface temperatures ranged between 468°C to 614°C. In all cases except when the slat angle was 0° and the blind was positioned closer to the outer glazing, the inner glazing surface temperature from the closest thermocouple (TC 14) above the fire room exceeded 600°C, the glass breakage temperature threshold. Overall, the Venetian blind position and slat opening angle influenced the spread of fire. Venetian blind combustibility and flammability were not considered and therefore recommended for future studies. Practical Application: Our manuscript helps to develop new thinking on mitigation of fire risks in buildings for architects, engineers and designers when incorporating Venetian blinds in Double Skin Façades (DSFs).
A sound-absorbing and heat-insulating collagen fiber composite material
Authors: Hui Chen Jiaxing Zhang , Shan Zhihua 
Published: September 2022

Using methacrylic acid (MAA) and methyl methacrylate (MMA) as core monomers and polystyrene as the shell layer, polymer hollow microspheres (PHM) with good stability were prepared by using an alkali osmotic swelling method followed by spray drying. The average size of the PHM was approximately 875 nm. As a filling cross-linking agent, the PHM were added to a skin collagen material to disperse and fix, and a “polymer hollow microsphere composite collagen fiber” (PHCC) material was obtained. The results show that the PHM improve the mechanical strength, thermal stability and water resistance of the skin collagen material. The PHCC material has a low thermal conductivity (0.035 W/(K·m)) and excellent sound insulation performance and retains the soft and delicate touch of leather, which has application value in high-grade decorative materials and functional leather. This provides a new approach for developing flexible sound-absorbing thermal insulation materials.
Awakening from the sleep-walking society: Crisis, detachment and the real in prepper awakening narratives
Authors: Barker Kezia 
Published: September 2022

Thoroughly saturated by ordinary crisis, routinized emergency and the normalization of apocalypticism, late-modern society is nevertheless depicted as sleep-walking into crisis; a further, overlapping crisis of the ‘real.’ This paper explores the potential of prepper awakening narratives – the moment preppers ‘wake up' to the reality of crisis – to contribute to explorations of detachment and denial in the Anthropocene. These narratives, part of the wider repertoire of prepper story-crafting, provide justification for the prepper’s transition to an anticipatory subjectivity, emotionally and sensually attuned to crisis and motivated to prepare. Extending existing conceptualizations of awakening, I argue that prepper awakenings are defined by the uncanny realization of distance from an ideal state of security. To illustrate, I consider narratives of bodily vulnerability, insecurity at home and abandonment in public places, which express shock at the failure of relationality implicit to the safety fictions of these spaces. In this reckoning with the ‘autonomous’ modern self the agential and aware prepper emerges, but this does not in itself lead to a renewed moment of politics or production of revolutionary consciousness. Instead, the horrifying real’ is recrafted as a vital space of self-reliance and resourcefulness, a place to reflect on endurance beyond this world-ending.
For Better or Worse: Self-reported Changes in Kratom and Other Substance Use as a Result of the COVID-19 Pandemic
Authors: Rogers Jeffrey M , Smith Kirsten E , Schriefer Destiny , Epstein David H 
Published: September 2022

Background: Kratom is taken to self-treat pain and symptoms of psychiatric disorders, including substance-use disorders (SUDs) and opioid withdrawal. Before COVID-19, kratom use was increasing in the US, however, there are few published data on whether that trend continued during the COVID-19 pandemic, which could have affected kratom use in multiple ways. Aim: To examine COVID-19-related changes in kratom use and how these changes were experienced, relative to changes in other commonly used substances. Methods: Using Amazon Mechanical Turk, 2615 evaluable surveys were completed between September 2020 and March 2021. Responses from past-month and past-year kratom-using adults (N = 174) indicating changes for the better or worse were examined using generalized linear mixed effects models, and relevant open-text responses (n = 85) were thematically coded. Results: For kratom 33% (n = 58) reported a Covid-related increase and 24% (n = 42) reported a Covid-related decrease. Controlling for changes in amount used, alcohol (OR = 5.02), tobacco (OR = 4.72), and nonmedical opioid use (OR = 3.42) were all more likely to have changed for the worse, compared with kratom use. Relative to decreases in kratom use, decreases in alcohol (OR = 3.21) and tobacco (OR = 6.18) use were more likely to be changes for the better. Cannabis use was the only substance to display a probability lower than 50% of being a decrease for the better, and of the increases, cannabis use displayed the highest probability of being for the better. Conclusions: Increases in kratom and cannabis use were less likely than alcohol and tobacco to be reported as changes for the worse, and decreases in kratom and cannabis use were more likely than alcohol and tobacco to be reported as changes for the better. These findings indicate that people differently conceptualize their relationships with kratom and cannabis, compared to their relationships with alcohol and tobacco.
Treatment of giant intracranial aneurysms using the Pipeline flow-diverting stent: Long-term results from the International Retrospective Study of the Pipeline Embolization Device (IntrePED) study
Authors: Grandhi Ramesh , Ravindra Vijay M. , Kallmes David F. , Lopes Demetrius , Hanel Ricardo A. , Lylyk Pedro 
Published: September 2022

Background Traditional endovascular treatments of giant intracranial aneurysms are associated with high rates of complications and retreatment. Our objective was to examine the safety and long-term efficacy of the Pipeline Embolization Device for treatment of these aneurysms. Methods This retrospective study using the IntrePED database included all patients with giant intracranial aneurysms treated with the Pipeline device between July 2008 and February 2013. Efficacy outcomes were stratified by using the Raymond-Roy Occlusion Classification. Predefined safety outcomes included spontaneous rupture of the target aneurysm; ipsilateral intracranial hemorrhage; ischemic stroke; parent artery stenosis; and sustained cranial neuropathy. Results Sixty-six embolizations were performed to treat 63 giant intracranial aneurysms (including 2 ruptured): 49 (77.8%) in the anterior and 14 (22.2%) in the posterior circulation. The median follow-up was 22.4 (0.1–60.5) months. Class I angiographic occlusion was achieved in 72.0% (36/50). The neurological morbidity/mortality rate was 23.8% (15/63), with higher rates in the posterior circulation than in the anterior circulation (22.4% vs. 28.6%). Among seven deaths, five had neurological causes. The procedure-related neurological morbidity and mortality rates were 22.7% (15/66) and 7.6% (5/66), respectively. The spontaneous rupture rate was 4.5% (3/66). Two spontaneous ruptures (1 death), 4/4 postprocedural intracranial hemorrhages, and 6/9 ischemic events occurred within 30 days. In-stent stenosis and new-onset cranial neuropathy were not observed during the angiographic follow-up period. Conclusions Although procedure-related neurological morbidity/mortality rates were not insignificant, this study confirms the feasibility and long-term efficacy of the Pipeline Embolization Device to treat giant intracranial aneurysms.
Blinding of outcome assessors and its association with outcome in a randomized open-label stroke trial
Authors: van der Ende Nadinda AM , Roozenbeek Bob , Broderick Joseph P , Khatri Pooja , Lingsma Hester F , Dippel Diederik WJ 
Published: September 2022

Background: It is challenging for outcome assessors to remain blinded during outcome assessment in trials with prospective randomized open blinded endpoint (PROBE) design. If assessors are able to guess the correct treatment allocation more often than expected based on chance, the assessors may have been not properly blinded. Aims: We aimed to assess blinding of outcome assessors in a stroke trial with PROBE design and its association with outcome. Methods: We used data of the Interventional Management of Stroke (IMS) III trial. The modified Rankin Scale (mRS) at 90 days was assessed by local assessors who were unaware of treatment allocation. To assess success of blinding, each assessor was asked to guess the patient’s treatment allocation. We assessed whether the percentage of correct guesses was higher than chance (i.e. 50%). The association between correctly guessed treatment allocation and the mRS at 90 days was analyzed with ordinal logistic regression stratified by treatment allocation. We tested for interaction of correctly versus incorrectly guessed treatment allocation with actual treatment allocation on the mRS. Patients with missing data on guessed treatment allocation and patients who died prior to 90-day assessment were excluded. Results: In total, 459 patients were included in this study. The assessors guessed the correct treatment allocation significantly more often than expected (267/459, 58.2%, one-sided p = 0.0003). Correctly guessed treatment allocations were associated with better mRS scores in the intervention group (common odds ratio (cOR): 2.28, 95% confidence interval (CI): 1.50–3.48) and with worse mRS scores in the control group (cOR: 0.47, 95% CI: 0.27–0.83) (pinteraction < 0.001). Conclusions: Assessors may not always be truly blinded for treatment allocation in clinical trials, and their guesses may be associated with outcome. Although causality between the assessors’ guess and patient outcome cannot be determined, future trials with subjective outcome should make efforts to ensure blinding and should report their blinding method and the success of blinding like the IMS III trial. Clinical Trial Registration: URL: https://clinicaltrials.gov . Unique identifier: NCT00359424.