bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS TUNGGAKAN PAJAK KENDARAAN BERMOTOR PROVINSI SULAWESI TENGGARA
Authors: Dinar Santi , Rosnawintang Rosnawintang , Nur Syamsir , Tajuddin Tajuddin , Burhanuddin Burhanuddin 
Published: November 2022

Tujuan penelitian ini yaitu menganalisis faktor-faktor yang mempengaruihi tunggakan pajak kendaraan bermotor di Provinsi Sulawesi Tenggara. Data yang digunakan yaitu data primer yang diperoleh dari kuisioner yang bagikan keada 100 orang responden. Hasil penelitian menunjukkan bahwa sanksi yang kurang tegas menjadi faktor yang menyebabkan wajib pajak melakukan tunggakan. Sanksi yang diberlakukan oleh Kantor Samsat Kendari masih sebatas denda yang ditentukan dari persentase jumlah pajaknya. Sehingga wajib pajak kendaraan bermotor masih tetap melakukan tunggakan pajak. Sementara faktor lain yaitu wajib pajak belum mengetahui bahwa sarana prasarana pajak yang harus dibayaran dapat diakses oleh wajib pajak. Kurangnya sosialisasi yang dilakukan oleh Kantor Samsat Kendari sehingga sebagian wajib pajak belum mengetahui bahwa sarana prasarana pajak dapat diakses via internet. Kata Kunci: Tunggakan Pajak, Kesadaran Wajib Pajak, Ketegasan Sanksi
ANALISIS PENGARUH PERTUMBUHAN EKONOMI, PENGANGGURAN TERBUKA DAN KEMISKINAN TERHADAP KETIMPANGAN PENDAPATAN DI PULAU SULAWESI
Authors: Zainuddin La Ode , Tamburaka Irmawatty P , Tajuddin Tajuddin , Ahmad Ahmad , Aedy Hasan , Balaka M. Yani 
Published: November 2022

Penelitian ini adalah untuk menganalisis pengaruh pertumbuhan ekonomi, pengangguran terbuka, jumlah penduduk, kemiskinan dan IPM terhadap ketimpangan pendapatan di Pulau Sulawesi. Jenis data dalam penelitian adalah data sekunder, diakses melalui website Badan Pusat Statistik dalam bentuk time series tahunan periode 2009-2020. Analisis yang digunakan adalah Regresi Data Panel.Software yang digunakan adalah Eviews 10. Hasil penelitian menunjukan bahwa (1) Pertumbuhan ekonomi berpengaruh signifikan terhadap ketimpangan pendapatan di Pulau Sulawesi. (2) Pengangguran terbuka berpengaruh signifikan terhadap ketimpangan pendapatan. (3) Kemiskinan berpengaruh terhadap ketimpangan pendapatan di Pulau Sulawesi. Kata Kunci: Ketimpangan Pendapatan, Pertumbuhan Ekonomi, Pengangguran Terbuka, Kemiskinan
Biochemical characteristics of patients with imported malaria
Authors: Bi Dewu , Lin Jianyan , Luo Xiaolu , Lin Lü , Tang Xike , Luo Xiaocheng , Lu Yuexi , Huang Xiaodong 
Published: November 2022

ObjectivesThis study aimed to investigate the clinical and biochemical profiles of patients with imported malaria infection between 1 January 2011 and 30 April 2022 and admitted to the Fourth People’s Hospital of Nanning.MethodsThis cohort study enrolled 170 patients with conformed imported malaria infection. The clinical and biochemical profiles of these participants were analyzed with malaria parasite clearance, and signs and symptoms related to malaria disappearance were defined as the primary outcome. A multivariable logistic regression model was used to evaluate the odds ratios (ORs) with 95% confidence intervals (CIs) for cerebral malaria. The Cox model was used to estimate the hazard ratios (HRs) with 95% CIs for parasite clearance.ResultsAdenosine deaminase and parasitemia were found to be independent risk factors for severe malaria in patients with imported malaria (OR = 1.0088, 95% CI: 1.0010–1.0167, p = 0.0272 and OR = 2.0700, 95% CI: 1.2584–3.4050, p = 0.0042, respectively). A 0.5–standard deviation (SD) increase of variation for urea (HR = 0.6714, 95% CI: 0.4911–0.9180), a 0.5-SD increase of variation for creatinine (HR = 0.4566, 95% CI: 0.2762–0.7548), a 0.25-SD increase of variation for albumin (HR = 0.4947, 95% CI: 0.3197–0.7653), a 0.25-SD increase of variation for hydroxybutyrate dehydrogenase (HR = 0.6129, 95% CI: 0.3995–0.9402), and a 1.0-SD increase of variation for ferritin (HR = 0.5887, 95% CI: 0.3799–0.9125) were associated with a higher risk for increased parasite clearance duration than a low-level change.ConclusionsAspartate aminotransferase, urea, creatinine, albumin, hydroxybutyrate dehydrogenase, and ferritin are useful biochemical indicators in routine clinical practice to evaluate prognosis for imported malaria.
Long-term outcomes in health-related quality of life influence chronic disease management in patients with pulmonary hypertension
Authors: Li Jin-Ling , Xiao Fan , Liu Hong-Ting , Li Hui-Ting , Zhao Qin-Hua , Sun Chun-Yan , Zhu Yan , Yan Lei , Wang Wen-Yue , Luo Hui , Gong Su-Gang , Jiang Rong , Liu Jin-Ming , Zhang Rui , Wang Lan 
Published: November 2022

BackgroundSignificantly improved survival in patients with pulmonary hypertension (PH) has raised interest in maintaining a good quality of long-term survivorship. In this study, health-related quality of life (HRQOL) measurement was used to assess the long-term changes of physical and mental outcomes.MethodsA total of 559 consecutive inpatients with PH completed generic HRQOL (Short Form-36) who were diagnosed with PH by right heart catheterization. Assessments were carried out at short-term (1 year), midterm (3 years), and long-term (5 years) follow-ups.ResultsPatients with PH suffered more severe impairments in both physical and emotional domains than the U.S. population normative values. Patients with PH due to chronic lung disease had the worst physical component summary (PCS) score, but there was no difference in mental component summary (MCS) score among different PH types. A reduced PCS score was correlated with WHO FC severity and pulmonary vascular resistance (PVR). The Z score showed that the changing trend of mental conditions continuously declined from baseline to midterm and long-term follow-ups, but the PCS score seemed to be stable or improved. Cox regression analysis indicated increased baseline PVR and WHO FC III and IV, and decreased physical subscale of role physical, mental subscale of social functioning, and the MCS score have increased risk of mortality in the long-term follow-up.ConclusionPatients with PH have poor HRQOL. The long-term change of physical status seemed to be stable, but the mental state was continuously worse. These suggested identifying and intervening mental health progresses is a noteworthy issue in PH chronic management.
Kinematics and geomorphological changes of a destabilising rock glacier captured from close-range sensing techniques (Tsarmine rock glacier, Western Swiss Alps)
Authors: Vivero Sebastián , Hendrickx Hanne , Frankl Amaury , Delaloye Reynald , Lambiel Christophe 
Published: November 2022

Accurately assessing landform evolution and quantifying rapid environmental changes are gaining importance in the context of monitoring techniques in alpine environments. In the European Alps, glaciers and rock glaciers are among the most characteristic cryospheric components bearing long and systematic monitoring periods. The acceleration in rock glacier velocities and the onset of destabilization processes, mainly since 1990, have raised several concerns due to the potential effects on the high alpine natural and anthropic environments. This study presents a combination of uncrewed aerial vehicle (UAV) and terrestrial laser scanning (TLS) surveys for monitoring the current changes on the quickly accelerating, destabilised Tsarmine rock glacier in the Arolla Valley, Western Swiss Alps, delivering a considerable volume of debris to a steep torrential gully. High-resolution digital elevation models (DEMs) and orthomosaics are derived from UAV image series combined with structure from motion (SfM) photogrammetry techniques. Multitemporal orthomosaics are employed for measuring spatially continuous rock glacier kinematics using image matching algorithms. Superficial displacements are evaluated with simultaneousin-situdifferential global navigation satellite system (GNSS) measurements. Elevation and volume changes are computed from TLS and UAV-derived DEMs at similar periods. Between June 2017 and September 2019, both datasets showed a similar elevation change pattern and surface thinning rates of 0.15 ± 0.04 and 0.16 ± 0.03 m yr−1, respectively. Downward of a rupture zone developing about 150 m above the front, the rock glacier doubled its overall velocity during the study period, from around 5 m yr−1between October 2016 and June 2017 to more than 10 m yr−1between June and September 2019. The kinematic information reveals striking differences in the velocity between the lower and upper rock glacier sections. The monitoring approach based on close-sensing techniques provides accurate surface velocity and volume change information, allowing an enhanced description of the current rock glacier dynamics and its surface expression.
Evaluation of plasma ACTH in the metyrapone test is insufficient for the diagnosis of secondary adrenal insufficiency
Authors: Papierska Lucyna , Rabijewski Michał , Migda Bartosz , Leszczyńska Dorota , Nowak Karolina , Łebek-Szatańska Agnieszka , Glinicki Piotr , Zgliczyński Wojciech 
Published: November 2022

ObjectiveTo determine whether a single measurement of ACTH instead of less available in daily practice 11-deoxycortisol assay is sufficient to rule out or confirm secondary adrenal insufficiency (SAI) in the short Metyrapone test.DesignA retrospective analysis of diagnostic tests (Metyrapone and Synacthen tests) performed at our Center between 2016 and 2018 in patients with suspicion of secondary adrenal insufficiency.Material and methodsIn 103 patients short metyrapone test was performed with assessment of 11-deoxycortisol and ACTH concentration after Metyrapone administered at midnight. In 89 of them short Synacthen (SST) test was also done (1 or/and 250 mcg 1-24ACTH). ROC curves have been performed to evaluate the diagnostic performance of ACTH level in metyrapone test as the predictor of secondary adrenal insufficiency (SAI) analysing sensitivity and specificity for various possible thresholds proposed in literature.Results40 (39%) of examined subjects were diagnosed as SAI, basing on post-Metyrapone 11-deoxycortisol concentration below 70 μg/l. In this group ACTH concentration was 128.1 ng/l (95% CI 96.8-159.4) versus 289.9 ng/l (95% CI 249.1-330.9) in patients with proper adrenal response. There was only a moderate positive correlation between ACTH and 11-deoxycortisol concentrations (r=0.5; p&lt;0.05). The best cut off value of ACTH in relation to 11-deoxycortisol serum concentrations was 147 ng/l - with sensitivity of 73.2% and specificity 83.9%. However, plasma ACTH was&gt;200ng/ml (the highest threshold proposed in literature) in 8 cases (20%) with positive diagnosis of SAI made on the basis of low 11-deoxycortisole and confirmed in short Synacthen test.ConclusionOur results indicate that for a valuable evaluation of the results of the metyrapone test, the more readily available plasma ACTH assay cannot replace the measurement of 11-deoxycortisol concentrations.
The prevalence and spectrum of reported incidental adrenal abnormalities in abdominal computed tomography of cancer patients: The experience of a comprehensive cancer center
Authors: Qdaisat Aiham , Bedrose Sara , Ezzeldin Obadah , Moawad Ahmed W. , Yeung Sai-Ching J. , Elsayes Khaled M. , Habra Mouhammed Amir 
Published: November 2022

BackgroundThe increasing use of computed tomography (CT) has identified many patients with incidental adrenal lesions. Further evaluation of these lesions is often dependent on the language used in the radiology report. Compared to the general population, patients with cancer have a higher risk for adrenal abnormalities, yet data on the prevalence and type of incidental adrenal lesions reported on radiologic reports in cancer patients is limited. In this study, we aimed to determine the prevalence and nature of adrenal abnormalities as an incidental finding reported on radiology reports of cancer patients evaluated for reasons other than suspected adrenal pathology.MethodsRadiology reports of patients who underwent abdominal CT within 30 days of presentation to a tertiary cancer center were reviewed and analyzed. We used natural language processing to perform a multi-class text classification of the adrenal reports. Patients who had CT for suspected adrenal mass including adrenal protocol CT were excluded. Three independent abstractors manually reviewed abnormal and questionable results, and we measured the interobserver agreement.ResultsFrom June 1, 2006, to October 1, 2017, a total of 600,399 abdominal CT scans were performed including 66,478 scans obtained within 30 days of the patient’s first presentation. Of these, 58,512 were eligible after applying the exclusion criteria. Adrenal abnormalities were identified in 7,817 (13.4%) reports, with adrenal nodularity (3,401 [43.5%]), adenomas (1,733 [22.2%]), and metastases (1,337 [17.1%]) being the most reported categories. Only 10 cases (0.1%) were reported as primary adrenal carcinomas and 2 as pheochromocytoma. Interobserver agreement using 300 reports yielded a Fleiss kappa of 0.893, implying almost perfect agreement between the abstractors.ConclusionsIncidental adrenal abnormalities are commonly reported in abdominal CT reports of cancer patients. As the terminology used by radiologists to describe these findings greatly determine the subsequent management plans, further studies are needed to correlate some of these findings to the actual confirmed diagnosis based on hormonal, histological and follow-up data and ascertain the impact of such reported findings on patients’ outcomes.
Tire and rubber particles in the environment—A case study from a hot arid region
Authors: Habib Rana Zeeshan , Al Kendi Ruwaya , Ghebremedhin Furtuna , Elkashlan Marim , Iftikhar Syed Haris , Poulose Vijo , Ramachandran Tholkappiyan , Mourad Abdel-Hamid Ismail , Hamed Fathalla , Thiemann Thies 
Published: November 2022

Materials made of rubber are a source of polymers released into the environment, where tire abrasions are a major contributor. In many hot, arid environs, whole tire losses are more common than in moderate climates, and lead to the accumulation of additional tire material on road sides, which over time can be the source of secondary micro-tires. Other rubber containing material from cars such as mud-flaps and floor mats has been seen as an appreciable additional source of micro-rubber. Due to the lack of precipitation, it is expected that modes of micro-tire relocation are more limited in arid regions than in more moderate climates. This 2-year study examines the rubber/tire content from 34 sampling sites within the region of Al Ain, Eastern region of Abu Dhabi Emirate, United Arab Emirates. The samplings include road dust, soil along roadsides, storm water run-off samples and samples collected in Wadis (creek beds that seasonally carry water) and one artificial lake. The mean average number of micro-tires in road dust was found to be 44.4 ± 40.6 micro-tires/g. In soil samples alongside the roads, it was 22.8 ± 42.1 micro-tires/g. The mean average size of micro-tires for all 34 sampling sites was found to be 106.9 ± 98.5 µm. It could be seen that rubber/tire materials desiccate over time during the high temperatures of the Emirati summer, become hard, brittle and break into smaller pieces, resulting in secondary micro-tire particles. The study of run-offs showed that tire particles are swept into storm drains during larger, very infrequently occurring rain events. However, the predominant mode of micro-tire transport was found to be on road by physical contact with cars, off-road by a combination of physical contact with moving objects and air movement. Samples taken from an artificial lake and three Wadis within the confines of Al Ain have shown only few micro-tire particles, so that the dispersion of micro-tires is not as pervasive as had been expected prior to this study.
Identification and expression analysis of zebrafish gnaq in the hypothalamic–Pituitary–Gonadal axis
Authors: Wang Chong , Yang Le , Xiao Tiaoyi , Li Junhua , Liu Qiaolin , Xiong Shuting 
Published: November 2022

The G proteins have emerged as essential molecular switches in a wide variety of signal transduction pathways. Gαq, encoded by G protein subunit alpha q (gnaq), is a member of the G proteins and participates in regulating important biological activities in mammals; however, its function and regulatory mechanism in teleost remain largely unclear. In the current study, we cloned the cDNA of gnaq from zebrafish (Danio rerio) and investigated the expression characteristics of Gαq/gnaq in reproductive tissues. RT-PCR and WISH analyses showed that gnaq was widely expressed in zebrafish tissues, with high expression in the brain, olfactory brain, and hypothalamus. During the embryonic development stage, the gnaq was mainly distributed in the hypothalamus after 72 h post-fertilization. In addition, immunohistochemistry analysis revealed that the Gαq protein was highly expressed in the diffuse nucleus of the inferior hypothalamic lobe (DIL), ventral zone of the periventricular hypothalamus (Hv), and caudal zone of the periventricular hypothalamus (Hc) in adult zebrafish. Furthermore, in the gonads, the Gαq protein was found in oocytes of all stages, except spermatids. Lastly, the gnaq mRNA exhibited relatively low expression in gonads on Day 4 during the reproductive cycle, while increasing drastically in the hypothalamus and pituitary afterward. Altogether, our results suggest that gnaq/Gαq might be important in fish reproduction.
Immunogenic cell death-related classifications in breast cancer identify precise immunotherapy biomarkers and enable prognostic stratification
Authors: Wang Xue , Huang Hailiang , Liu Xijian , Li Jiuwei , Wang Lu , Li Ling , Li Yaxing , Han Tao 
Published: November 2022

Background: Immunogenic cell death (ICD) remodels the tumor immune microenvironment, plays an inherent role in tumor cell apoptosis, and promotes durable protective antitumor immunity. Currently, appropriate biomarker-based ICD immunotherapy for breast cancer (BC) is under active exploration.Methods: To determine the potential link between ICD genes and the clinical risk of BC, TCGA-BC was used as the training set and GSE58812 was used as the validation set. Gene expression, consistent clustering, enrichment analysis, and mutation omics analyses were performed to analyze the potential biological pathways of ICD genes involved in BC. Furthermore, a risk and prognosis model of ICD was constructed to evaluate the correlation between risk grade and immune infiltration, clinical stage, and survival prognosis.Results: We identified two ICD-related subtypes by consistent clustering and found that the C2 subtype was associated with good survival prognosis, abundant immune cell infiltration, and high activity of immune biological processes. Based on this, we constructed and validated an ICD risk and prognosis model of BC, including ATG5, HSP90AA1, PIK3CA, EIF2AK3, MYD88, IL1R1, and CD8A. This model can effectively predict the survival rate of patients with BC and is negatively correlated with the immune microenvironment and clinical stage.Conclusion: This study provides new insights into the role of ICD in BC. The novel classification risk model based on ICD in BC established in this study can aid in estimating the potential prognosis of patients with BC and the clinical outcomes of immunotherapy and postulates targets that are more useful in comprehensive treatment strategies.
Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles
Authors: Walker Andreas , Schwarz Tatjana , Brinkmann-Paulukat Janine , Wisskirchen Karin , Menne Christopher , Alizei Elahe Salimi , Kefalakes Helenie , Theissen Martin , Hoffmann Daniel , Schulze zur Wiesch Julian , Maini Mala K. , Cornberg Markus , Kraft Anke RM , Keitel Verena , Bock Hans H. , Horn Peter A. , Thimme Robert , Wedemeyer Heiner , Heinemann Falko M. , Luedde Tom , Neumann-Haefelin Christoph , Protzer Ulrike , Timm Jörg 
Published: November 2022

Background and aimsThere is growing interest in T cell-based immune therapies for a functional cure of chronic HBV infection including check-point inhibition, T cell-targeted vaccines or TCR-grafted effector cells. All these approaches depend on recognition of HLA class I-presented viral peptides. The HBV core region 18-27 is an immunodominant target of CD8+ T cells and represents the prime target for T cell-based therapies. Here, a high-resolution analysis of the core18-27 specific CD8+ T cell and the selected escape pathways was performed.MethodsHLA class I typing and viral sequence analyses were performed for 464 patients with chronic HBV infection. HBV-specific CD8+ T-cell responses against the prototype and epitope variants were characterized by flow cytometry.ResultsConsistent with promiscuous presentation of the core18-27 epitope, antigen-specific T cells were detected in patients carrying HLA-A*02:01, HLA-B*35:01, HLA-B*35:03 or HLA-B*51:01. Sequence analysis confirmed reproducible selection pressure on the core18-27 epitope in the context of these alleles. Interestingly, the selected immune escape pathways depend on the presenting HLA-class I-molecule. Although cross-reactive T cells were observed, some epitope variants achieved functional escape by impaired TCR-interaction or disturbed antigen processing. Of note, selection of epitope variants was exclusively observed in HBeAg negative HBV infection and here, detection of variants associated with significantly greater magnitude of the CD8 T cell response compared to absence of variants.ConclusionThe core18-27 epitope is highly variable and under heavy selection pressure in the context of different HLA class I-molecules. Some epitope variants showed evidence for impaired antigen processing and reduced presentation. Viruses carrying such escape substitutions will be less susceptible to CD8+ T cell responses and should be considered for T cell-based therapy strategies.
Antiviral prophylaxis or preemptive therapy for cytomegalovirus after liver transplantation?: A systematic review and meta-analysis
Authors: Yadav Dipesh Kumar , Adhikari Vishnu Prasad , Yadav Rajesh Kumar , Singh Alina , Huang Xing , Zhang Qi , Pandit Prabesh , Ling Qi , Liang Tingbo 
Published: November 2022

BackgroundTo conduct a meta-analysis with the aim of comparing the outcomes of antiviral prophylaxis and preemptive therapy for the prevention of cytomegalovirus (CMV) infection in liver transplant (LT) recipients.MethodsWe searched databases for qualified studies up until March 2022. Finally, a meta-analysis was carried out using a fixed-effect or random-effect model based on the heterogeneity.ResultsWith a total of 1834 LT patients, the pooled incidence of CMV infection and CMV disease in the overall LT recipients using antiviral prophylaxis and preemptive therapy were 24.7% vs. 40.4% and 6.4% vs. 9.4%, respectively. Our meta-analysis exhibited a significant reduction in the incidence of CMV infection due to antiviral prophylaxis when compared to preemptive therapy in the high-risk group (OR: 6.67, 95% CI: 1.73, 25.66; p = 0.006). In contrast, there was a significant reduction in the incidence of late-onset of CMV disease in preemptive therapy compared to antiviral prophylaxis in the high-risk group (OR: 0.29, 95% CI: 0.12, 0.74; p = 0.009). However, the incidence of CMV disease, allograft rejection, graft loss, drug related adverse effects, opportunistic infections and mortality did not differ significantly between both the interventions (all p&gt; 0.05).ConclusionsWe found the use of antiviral prophylaxis, compared with preemptive therapy, is superior in controlling CMV infection and prolonging the time to CMV disease in LT recipients without an increased risk of opportunistic infections, allograft rejection, graft loss, drug related adverse effects, development of drug resistance, and mortality.