bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bestandsentwicklung in der Webarchivierung – Einsatzmöglichkeiten für Methoden der Digital Humanities
Authors: Schmid Katharina , Schoger Astrid , Weimer Konstanze 
Published: May 2022

Zusammenfassung
Die Auswahl archivwürdiger Websites für kuratierte Webarchivsammlungen ist ein ressourcenintensiver Prozess. Methoden der Digital Humanities, insbesondere der Text- und Linkanalyse, können gewinnbringend zur Unterstützung der Bestandsentwicklung in der selektiven Webarchivierung angewendet werden. In diesem Beitrag wird ein im Rahmen eines DFG-Projekts entwickeltes und an der Bayerischen Staatsbibliothek prototypisch umgesetztes Verfahren vorgestellt. Die Möglichkeiten und Herausforderungen des Einsatzes computergestützter Methoden beim Bestandsausbau in der Webarchivierung werden bewertet.
Quality changes of repeatedly fried palm oil and extracted oil from fried loach
Authors: Zheng Jie , Long Yuanyuan , Chen Wen , Zhi Wenli , Xu Tingting , Wang Lin , Hu Aijun 
Published: May 2022

Abstract
Fried loach is a kind of popular flavor food. The effects of repeated frying on peroxide value (PV), acid value (AV), P-anisidine value (P-AV), total polar components (TPC) and free fatty acids (FFA) of palm oil and extracted oil from fried loach (EOL) were studied. The loach was fried in palm oil at 170 °C for 3 min and the frying was repeated 10 times. The oil from fried loach was collected and analyzed. The results showed that the TPC of palm oil exceeded the standard limit (3 mg/g) when frying 10 times. The PV and TPC of EOL were unqualified after 9 and 4 times frying (19.17 meq O2/kg and 31% respectively). The AV of the EOL reached 2.46 mg/g after 9 times frying. Palm oil has better frying performance than EOL because of its balanced proportion of saturated and unsaturated fatty acids. Palm oil can be used for 9 times frying, while the EOL has been damaged after 4 times.
Skeletal muscle RUNX1 is related to insulin sensitivity through its effect on myogenic potential
Authors: Stefanowicz Magdalena , Nikołajuk Agnieszka , Matulewicz Natalia , Strączkowski Marek , Karczewska-Kupczewska Monika 
Published: May 2022

Abstract

Objective
Skeletal muscle is the major site of insulin action. There are limited data on the relationship between insulin action and skeletal muscle myogenic/regenerative potential. RUNX1 is a transcription factor which plays a role in muscle development and regeneration. The aim of our study was to assess the role of skeletal muscle myogenic/regenerative potential in the development of insulin resistance through the studies on RUNX1 transcription factor.

Design
This study is a cross-sectional study. Experimental part with myoblast cell line culture.

Methods
We examined 41 young healthy volunteers, 21 normal weight and 20 with overweight or obesity. Hyperinsulinemic-euglycemic clamp and vastus lateralis muscle biopsy were performed. In L6 myoblast and human skeletal muscle myoblasts (hSkMM) cell cultures, RUNX1 was silenced at two stages of development. Cell growth, the expression of markers of myogenesis, nuclei fusion index, Akt phosphorylation and glucose uptake were measured.

Results
Skeletal muscle RUNX1 expression was decreased in overweight/obese individuals in comparison with normal-weight individuals and was positively related to insulin sensitivity, independently of BMI. Runx1 loss-of-function at the stage of myoblast inhibited myoblast proliferation and differentiation and reduced insulin-stimulated Akt phosphorylation and insulin-stimulated glucose uptake. In contrast, Runx1 knockdown in myotubes did not affect Akt phosphorylation, glucose uptake and other parameters studied.

Conclusions
Myogenic/regenerative potential of adult skeletal muscle may be an important determinant of insulin action. Our data suggest that muscle RUNX1 may play a role in the modulation of insulin action through its effect on myogenesis.
Dose–exposure–IGF-I response of once-weekly somapacitan in adults with GH deficiency
Authors: Kildemoes Rasmus Juul , Hollensen Christian , Biller Beverly M K , Johannsson Gudmundur , Takahashi Yutaka , Rasmussen Michael Højby 
Published: May 2022

Abstract

Objective
Growth hormone (GH) replacement therapy in patients with adult growth hormone deficiency (AGHD) is individually titrated due to variable dose–responses among patients. The aim of this study was to provide clinical guidance on dosing and titration of the novel long-acting GH derivative somapacitan based on analyses of somapacitan dose–insulin-like growth factor I (IGF-I) responses in AGHD patients.

Design
Analyses of dosing information, 4364 somapacitan concentration samples and 4880 IGF-I samples from 330 AGHD patients treated with somapacitan in three phase 3 trials.

Methods
Pharmacokinetic/pharmacodynamic modelling was used to evaluate starting dose groups by age and oral oestrogen therapy, characterise the dose–IGF-I response in the overall AGHD population and patient subgroups, predict the IGF-I response to dose changes and simulate missed dosing.

Results
The analyses supported the clinical recommendations of higher starting doses for younger patients and women on oral oestrogen replacement therapy. For patients switching from daily GH treatment, the mean maintenance dose ratio between somapacitan (mg/week) and somatropin (mg/day) was predicted to be 8.2 (observed interquartile range of 6.7–9.1). Simulations of IGF-I SDS profiles confirmed the appropriate time for IGF-I sampling to be 3–4 days after somapacitan dosing and supported somapacitan administration with up to 3 days delay in case of missed dosing. Subgroup analyses characterised the dose–exposure–IGF-I response in patient subgroups and indicated that dose requirements are mainly influenced by sex and oral oestrogen treatment.

Conclusions
This study extends the knowledge of the somapacitan dose–IGF-I response and provides information on clinical dosing of once-weekly somapacitan in patients with AGHD.
Pancreatic neuroendocrine neoplasms: survival trend analysis of a comprehensive center
Authors: Coelho Sara , Costa Cláudia , Santos Ana Paula , Souteiro Pedro , Oliveira Joana , Oliveira Júlio , Azevedo Isabel , Torres Isabel , Bento Maria José 
Published: May 2022

Objectives
Therapeutic options for pancreatic neuroendocrine neoplasia (Pan-NEN) have increased over the last decade. We aim to understand the evolution of the prognosis of patients with diagnosis of Pan-NEN within a 12-year period, considering the implementation of new treatments.

Methods
This study is a retrospective cohort study of patients diagnosed with Pan-NENs between 2006 and 2017. Survival outcome estimates were calculated by Kaplan–Meier method. The impact of baseline clinicopathological characteristics on survival was explored with the use of Cox proportional hazard model.

Results
Of the 97 patients, 77 (79.9%) had well-differentiated neuroendocrine tumor (NET) according to WHO 2010 classification, and 52 (53.6%) had localized or locoregional disease. There were no differences between clinicopathological characteristics and survival outcomes when comparing patients diagnosed between 2006–2011 and 2012–2017. Neuroendocrine carcinoma – HR 2.76, 95% CI 1.17–6.55 – and stages III and IV at diagnosis were independent poor prognostic factors – HR 6.02, 95% CI 2.22–16.33 and HR 6.93, 95% CI 2.94–16.32, respectively.

Conclusions
The new therapeutic approaches did not induce better survival outcomes on Pan-NEN in recent years. This is possibly due to the indolent nature of NET grades 1 and 2, even metastatic, allowing patients to be submitted to new target therapies along their disease course.
Endometriosis in transmasculine individuals
Authors: Ferrando Cecile A 
Published: May 2022

Lay summary
Transmasculine people are assigned female at birth but identify as male. These patients often are prescribed testosterone therapy as part of their transition. This treatment can affect ovulation and stop menstrual periods. Endometriosis is a common condition that causes pelvic pain in some people born with female pelvic organs. Not a lot is known about transmasculine people and how often endometriosis affects them. Testosterone should help treat if not reduce the incidence of endometriosis. This commentary looks at the current literature in order to help clarify existing knowledge gaps. Transmasculine patients who present for hysterectomy as a surgery to help them affirm themselves in their self-identified gender sometimes report pelvic pain symptoms as well. There are many reasons why patients report pain before surgery, and this can be related to endometriosis, even though this diagnosis is less expected in this group. Providers caring for transmasculine patients should be aware of this.
Modelagem Matemática, BNCC e a prova do ENEM de 2019: confluências e reflexões
Authors: De Oliveira Lozada Claudia , De Oliveira Lozada Anneliese 
Published: May 2022

Neste trabalho fazemos uma análise das questões da prova de Matemática e suas Tecnologias do Exame Nacional do Ensino Médio - ENEM 2019 que ensejam a modelagem matemática. Para tanto, tecemos considerações sobre as habilidades e competências previstas pela Base Nacional Comum Curricular e a Matriz de Referência do ENEM para verificar as confluências, assim como para uma melhor análise utilizamos a pesquisa qualitativa e classificamos as questões de acordo com uma tipologia, fornecendo deste modo parâmetros balizadores acerca das articulações dos conhecimentos para a resolução das questões. Os resultados desta pesquisa demonstraram que há um quantitativo considerável de questões do ENEM 2019 que ensejam a modelagem matemática, sendo que houve uma preponderância do tipo 4, que são questões que podem ser resolvidas intuitivamente ou elaborando um modelo matemático, assim como uma prevalência do nível fácil nas questões analisadas e interdisciplinaridade com seis componentes curriculares da Educação Básica. Desta forma, trazemos uma nova reflexão sobre as modelagens matemáticas existentes, em especial, a modelagem matemática por meio de situações-problema e como o professor pode trabalhá-la nas aulas de Matemática, a partir de questões do ENEM.
Early circulating strain of SARS-CoV-2 causes severe pneumonia distinct from that caused by variants of concern in mice transduced with an adenoviral vector expressing human ACE2
Authors: Matsumoto Yusuke , Yasui Fumihiko , Endo Akinori , Sanada Takahiro , Munakata Tsubasa , Takagi Asako , Yamaji Kenzaburo , Yamamoto Naoki , Saeki Yasushi , Kohara Michinori 
Published: May 2022

Abstract
To analyze the molecular pathogenesis of SARS-CoV-2, a small animal model such as mice is needed: human ACE2, the receptor of SARS-CoV-2, needs to be expressed in the respiratory tract of mice. We conferred SARS-CoV-2 susceptibility in mice by using an adenoviral vector expressing hACE2 driven by an EF1α promoter with a leftward orientation. In this model, severe pneumonia like human COVID-19 was observed in SARS-CoV-2-infected mice, which was confirmed by dramatic infiltration of inflammatory cells in the lung with efficient viral replication. An early circulating strain of SARS-CoV-2 caused the most severe weight loss when compared to SARS-CoV-2 variants of concern, although histopathological findings, viral replication, and cytokine expression characteristics were comparable. We found that a distinct proteome of an early circulating strain infected lung characterized by elevated complement activation and blood coagulation, which were mild in other variants, can contribute to disease severity. Unraveling the specificity of early circulating SARS-CoV-2 strains is important in elucidating the origin of the pandemic.
Prevalence of subclinical activity by ultrasound examination in Mexican children with Juvenile Idiopathic Arthritis in remission
Authors: Nuñez Myriam Mendez , Nuñez Myriam Mendez , Medina-Avalos María Fernanda , Tlacuilo-Parra Jose Alberto 
Published: May 2022

Abstract
Background
Juvenile Idiopathic Arthritis (JIA) is a chronic disease that affects 0.6–1.9 /1,000 children. Persistent joint inflammation conditions cartilage damage and erosions. Recent studies have shown that clinical examination significantly underestimates joint inflammation, with ultrasound having a higher sensitivity. We determined the prevalence of subclinical synovitis by musculoskeletal ultrasound in Mexican children with JIA in remission.
Methods
Cross-sectional study, patients with JIA in clinical remission based on the Wallace criteria were included, with and without pharmacological treatment, we also included a control group of healthy children. The evaluation was performed by a certified Rheumatologist in Pediatric Musculoskeletal Ultrasound by EULAR. Joints clinically examined were also evaluated following the standard guidelines.
Results
We included 37 JIA patients with clinical remission and 33 healthy children (1260 joints scanned), subclinical activity was detected in 15/37 (40.5%) patients and none of healthy peers; 14 patients were still on treatment (93.3%). The subclinical activity was detected using B-mode in 22/1260 (1.7%) or by power Doppler (PD) in 15/1260 (1.1%) joints, the knee was involved in 13/22 (59%) joints. The subtype mainly affected was the rheumatoid factor-positive (FR) polyarticular (33.3%), erosions were detected in three patients (8%). In the knee, we observed slight distention of the supra patellar recess, evidenced in 19/33 healthy children (57.5%), predominantly among children aged 4 to 8 years. When comparing the groups with or without subclinical synovitis, no statistically significant differences were found with regard to age, evolution time or acute phase reactants.
Conclusions
Subclinical synovitis was detected in 40.5% of the patients in clinical remission using B-mode or by power Doppler, mainly on those who were still on treatment. The most affected subtype was the rheumatoid factor-positive polyarticular, the knees were the most frequent involved. In the healthy peers, a slight distention of the supra patellar recess was observed in almost half of cases.
TMBIM1 promotes EMT by stimulating autophagic degradation of E-cadherin via AMPK/mTOR/ULK1 axis in human gliomas
Authors: Gao Lun , Liu Junhui , Zhang Shenqi , Li Yong , Tan Yinqiu , Yang Ji’an , Cai Jiayang , Wang Long , Yuan Fan’en , Ye Zhang , Tong Shi’ao , Liu Baohui , Tian Daofeng , Deng Gang , chen qianxue 
Published: May 2022

Abstract
Background

Gliomas are the most common malignant tumors of the central nervous system in adults, glioblastoma is notorious for its highly metastatic and recurrent, accounting for approximately 50% of all gliomas. Exploring its molecular mechanism is urgently needed for the treatment and prognosis evaluation of gliomas. Transmembrane BAX inhibitor motif-containing 1 (TMBIM1) has been reported to be associated with non-alcoholic steatohepatitis, tumor and other diseases. However, the role of TMBIM1 in GBM and the underlying mechanisms remains unclear.

Methods

The expression level and prognostic value of TMBIM1 in gliomas were investigated by public datasets, and further confirmed by western blot and immunohistochemistry (IHC) in our tissues. Intracranial xenograft model, IHC and western blot were used to evaluate the functional role of TMBIM1.

Results

TMBIM1 was over-expressed in GBM, and its high expression reduced the survival time of glioma patients. TMBIM1 induced EMT and autophagy, and inhibition of autophagy reverses TMBIM1-regulated EMT in vitro and in vivo. Intracranial xenograft model showed the survival time of mice in TMBIM1 knockdown group treated with chloroquine (CQ)was significantly prolonged. The loss of E-cadherin expression is considered the foundation of EMT, and we subsequently demonstrated that TMBIM1 stimulating autophagic degradation of E-cadherin via AMPK/mTOR/ULK1 axis.

Conclusion

Our study provides a novel mechanism for the regulation of EMT in the process of gliomas metastasis, indicating that inhibition of TMBIM1 activity to attenuate autophagy may be a potential strategy for the treatment of gliomas.
Phenotyping of fecal microbiota of Winnie, a rodent model of spontaneous chronic colitis, reveals specific metabolic, genotoxic, and pro-inflammatory properties
Authors: Talà Adelfia , Guerra Flora , Resta Silvia Caterina , Calcagnile Matteo , Barca Amilcare , Tredici Salvatore Maurizio , De Donno Maria Dolores , Vacca Mirco , Liso Marina , Chieppa Marcello , De Angelis Maria , Verri Tiziano , Bozzetti Maria Giuseppina , Bucci Cecilia , Alifano Pietro 
Published: May 2022

Abstract
Winnie, a mouse carrying a missense mutation in the MUC2 mucin gene, is a valuable model for inflammatory bowel disease (IBD) with signs and symptoms that have multiple similarities with those observed in patients with ulcerative colitis. MUC2 mucin is present in Winnie, but is not firmly compacted in a tight inner layer. Indeed, these mice develop chronic intestinal inflammation due to the primary epithelial defect with signs of mucosal damage, including thickening of muscle and mucosal layers, goblet cell loss, increased intestinal permeability, enhanced susceptibility to luminal inflammation-inducing toxins, and alteration of innervation in the distal colon. In this study, we show that the intestinal environment of the Winnie mouse, genetically determined by MUC2 mutation, selects an intestinal microbial community characterized by specific pro-inflammatory, genotoxic and metabolic features that could imply a direct involvement in the pathogenesis of chronic intestinal inflammation. We report results obtained by using a variety of in vitro approaches for fecal microbiota functional characterization. These approaches include Caco-2 cell cultures and Caco-2/THP-1 cell co-culture models for evaluation of geno-cytotoxic and pro-inflammatory properties using a panel of 43 marker RNAs assayed by RT-qPCR, and cell-based phenotypic testing for metabolic profiling of the intestinal microbial communities by Biolog EcoPlates. While adding a further step towards understanding the etiopathogenetic mechanisms underlying IBD, the results of this study provide a reliable method for phenotyping gut microbial communities, which can complement their structural characterization by providing novel functional information.
Control effect of coal mining solid-waste backfill for ground surface movement in slice mining: A case study of the Nantun Coal Mine
Authors: Zhu Cunli , Zhang Jixiong , Abbas Taheri , Zhou Nan , Li Zejun , Li Meng 
Published: May 2022

Abstract
Management of solid waste and protecting the ecological balance of the region are key challenges that the coal mining industry has to face. This study evaluated the effect of solid waste backfilling mining on the overlying strata movement and surface deformation variation pattern in slice mining. The mechanical characteristics of different cemented paste backfills (CPB) were compared. The CPB specimens were made of coal gangue and cement with or without the addition of fly ash. The experiments showed that the mechanical strength of the CPBs made of coal gangue and cement increased dramatically. A numerical simulation was then performed to analyze the variation patterns of the overlying strata displacement and surrounding rock stress distribution before and after filling the 3lower and 3upper coal seams with CPB. The CPBs reduced the movement of the surface by 95.1% and 95% during the mining of the 3lower and 3upper coal seams, respectively. Finally, we used a mining-induced subsidence prediction and analysis system to predict the influence of the 3lower and 3upper coal seams on the ground surface subsidence. It was found that the ground surface subsidence induced by CPB mining was 1/20 that of the cumulative ground surface subsidence caused by caving mining. CPB mining could effectively control the ground surface subsidence caused by multi-slice mining of the thick coal seam, offering protection for buildings above the ground. Our research provides theoretical and technical support for coal mining under buildings subjected to similar conditions.
Research on motion match characteristics of a two degree of freedom spring system with impact and momentum offset
Authors: Wang Yang , Xu Cheng , He Long 
Published: May 2022

Abstract
In this paper, the motion parameters of a physical prototype which based on a new floating technology with the bidirectional buffer spring is measured. A two degree of freedom floating machine gun model with impact and momentum offset is establishedcal, culated and analyzed. By comparing with the measured results, the correctness of the model is verified. The influence of bidirectional buffer spring and recoil spring stiffness on the motion characteristics, especially the recoil ending state of the floating body, floating efficiency and consistency of firing state are analyzed. The research shows that the stiffness increasing of bidirectional buffer spring accelerates the frequency of the forced recoil-return amplitude attenuated simple harmonic motion of the floating body, and lags the phase of the bolt carrier group relative to the floating body at the firing time; increasing the stiffness of the recoil spring increases the motion frequency of the bolt carrier group, and advances the phase of the bolt carrier group relative to the floating body at the firing time, which both have an influence on recoil ending state of the floating body, the floating efficiency and the consistency of the firing state. Keywords: Momentum offset; Two degree of freedom system; Floating technology; Machine gun system
Fabrication, physical, structure characteristics, neutron and radiation shielding capacity high density neodymio-cadmium lead borate glasses: Nd2O3/CdO/PbO/B2O3/Na2O
Authors: Rammah Yasser , Alsaif Norah , Issa Shams , Henaish Ahmed , Ahmed Emad , Zakaly Hesham 
Published: May 2022

Abstract
High density glasses of neodymio-cadmium lead borate of chemical composition xNd2O3/20CdO/20PbO/(57-x)B2O3/3Na2O, where (0 (0Nd) ≤ x ≤ 5 (5Nd) wt%) have been fabricated by a melt quenching process. Physical, structure properties as well as gamma-radiation and neutron shielding effectiveness in wide photon energy range 0.015-15 MeV have been examined. The amorphous nature of xNd-glasses was confirmed, where there was a lack of their crystallinity. Density was gradually increased from 5.006 g/cm3 for 0Nd-glass sample to 5.245 g/cm3 for 5Nd-glass sample. In terms of the MAC, introducing Nd3+ ions in the glass matrix has a direct constructive influence on the obtained values of MAC. Generally, the MAC trend follows the order (MAC)5Nd > (MAC)4Nd > (MAC)3Nd > (MAC)2Nd > (MAC)1Nd > (MAC)0Nd. The LAC has a similar trend as MAC for all xNd-glasses. In terms of the T1/2, the 5Nd-glasses possessed the minimum T1/2 values (0.004 cm at 15 keV to 4.301 cm at 15 MeV). Therefore, the T1/2 of the fabricated xNd-glasses has an inverse behavior of the MAC and LAC. Thus, (T1/2)0Nd > (T1/2)1Nd > (T1/2)2Nd > (T1/2)3Nd > (T1/2)4Nd > (T1/2)5Nd. the Zeff parameter follows the order (Zeff)5Nd > (Zeff)4Nd > (Zeff)3Nd > (Zeff)2Nd > (Zeff)1Nd > (Zeff)0Nd. In the energies preferred for radiation applications, 5Nd-glasses possess very low EBF and EABF values. The FNRC of the fabricated glasses is improved as the Nd3+ content increases in the glass matrix.