bluuebunny/crossref_metadata_2025_split huggingface dataset:
Videogames and (language) education
Authors: Koutsogiannis Dimitrios , Adampa Vasiliki 
Published: July 2022

There is a productive discussion concerning the use of videogames in (literacy) education, focusing on their unique pedagogic potentials and on their interconnection with contemporary developments in textual and semiotic issues. Our main aim is to extend this discussion towards a more critical post-videogaming perspective, in the sense that videogames have to be considered as part and parcel of the contemporary, complex socio-cultural and historical context. Therefore, we focus on highlighting indicative aspects of this complexity, and we adopt concepts from the field of critical sociolinguistics, such as scales, strategies, and orders of literacy. We analyze a combination of quantitative (1.185 questionnaires) and qualitative data (6 ethnographic case studies) originating from children 11-15 years old. Our analysis reveals that, although videogaming tends to be a common youth practice, the other important differences/inequalities permeating parenting strategies, school practices, and children’s literate identities remain unchanged, posing serious questions in terms of the promising educational use of videogames. We propose a historically sensitive perspective in order to connect videogames with schooling and especially L1 teaching.
Telomere Length as a Marker of Biological Aging: A Critical Review
of Recent Literature
Authors: Daios Stylianos , Anogeianaki Antonia , Kaiafa Georgia , Kontana Anastasia , Veneti Stavroula , Gogou Christiana , Karlafti Eleni , Pilalas Dimitrios , Kanellos Ilias , Savopoulos Christos 
Published: July 2022

Introduction:
Aging is characterized as a syndrome of deleterious, progressive, universal, and irreversible function changes affecting every structural and functional aspect of the organism and accompanied by a generalized increase in mortality. Although a substantial number of candidates for biomarkers of aging have been proposed, none has been validated or universally accepted. Human telomeres constitute hexameric repetitive DNA sequence nucleoprotein complexes that cap chromosome ends, regulating gene expression and modulating stress-related pathways. Telomere length (TL) shortening is observed both in cellular senescence and advanced age, leading to the investigation of TL as a biomarker for aging and a risk factor indicator for the development and progression of the most common age-related diseases.

Objective:
The present review underlines the connection between TL and the pathophysiology of the diseases associated with telomere attrition.

Methods:
We performed a structured search of the PubMed database for peer-reviewed research of the literature regarding leukocyte TL and cardiovascular diseases (CVD), more specifically stroke and heart disease, and focused on the relevant articles published during the last 5 years. We also applied Hill’s criteria of causation to strengthen this association.

Result:
We analyzed the recent literature regarding TL length, stroke, and CVD. Although approximately one-third of the available studies support the connection, the results of different studies seem to be rather conflicting as a result of different study designs, divergent methods of TL determination, small study samples, and patient population heterogeneity. After applying Hill’s criteria, we can observe that the literature conforms to them weakly, with chronology being the only Hill criterion of causality that probably cannot be contested.

Conclusion:
The present review attempted to examine the purported relation between leukocyte TL and age-related diseases such as CVD and more specific stroke and heart disease in view of the best established, comprehensive, medical and epidemiological criteria that have characterized the focused recent relevant research. Although several recommendations have been made that may contribute significantly to the field, a call for novel technical approaches and studies is mandatory to further elucidate the possible association.
Therapeutic Potential of P2X7 Purinergic Receptor Modulation in the Main Organs
Affected by the COVID-19 Cytokine Storm
Authors: Batista Simões Júlia Leão , Sobierai Leilane Dayane , Pereira Stefany Maciel , Rodrigues dos Santos Miriam Vitória , Bagatini Margarete Dulce 
Published: July 2022

Abstract:
Defined by the World Health Organization as a global public health pandemic, coronavirus 2019 (COVID-19) has a global impact and the death of thousands of people. The “severe acute respiratory syndrome coronavirus 2” virus (SARS-CoV-2) is the etiologic agent of this disease, which uses the angiotensin-converting enzyme receptor 2 (ACE2) to infect the body, so any organ that expresses the gene ACE2 is a possible target for the new coronavirus. In addition, in severe cases of COVID-19, a cytokine storm occurs, which triggers widespread systemic inflammation due to the uncontrolled release of proinflammatory cytokines. In this perspective, the modulation of purinergic receptors are highlighted in the literature as a possible therapy, considering its application in other viral infections and systemic inflammation. Therefore, the objective of this review is to gather information on the modulation of the P2X7 receptor in the main organs directly affected by the virus and by the cytokine storm: heart, brain, lung, liver and kidneys. Thus, demonstrating possible therapies for reducing inflammation, as well as reducing the level of morbidity and mortality of COVID-19.
Analysis of the Molecular Mechanism of Huangqi Herb Treating COVID-
19 with Myocardial Injury by Pharmacological Tools, Programming Software
and Molecular Docking
Authors: Zhou Yan , Chu Yuguang , Shi Jingjing , Hu Yuanhui 
Published: July 2022

Background:
Huangqi with the capacity to resist virus and preserve myocardium is a
potential herb for treating patients with COVID-19 and related myocardial injury.

Method:
We applied network pharmacology method and programming software including R and
Perl to explore the probable mechanism of Huangqi fighting against the disease. Ingredients and
target gene names of Huangqi were obtained from TCMSP database. Disease-associated genes
were mined by searching GeneCards database. Venny online software was applied to draw Venn
diagram of intersection genes. Cytoscape software was used to set up the network of disease, drug,
compounds and targets. STRING database was applied to set up protein protein interaction (PPI)
network. With intersection genes imported into WEBGESALT database, gene ontology (GO)
analysis was completed. An R script basing on Kyoto Encyclopedia of Genes and Genomes
(KEGG) database was applied to obtain KEGG pathways. Finally, we used AutoDockTools 1.5.6
software for molecular docking and PyMOL to visualize the docking details.

Results:
We obtained 20 active components and 18 potential target genes to construct a network,
and found out quercetin and kaempferol were core ingredients. Key targets included EGFR,
MAPK8, IL6, CASP3, RELA and PPARG. Huangqi showed its potential to reduce inflammatory
response to prevent cytokine storm by inhibiting EGFR, IL6 and MAPK and protect myocardium
by inhibiting apoptosis and oxidant stress. Huangqi may also work by adjusting ubiquitin and regulating
multiple viral pathways.

Conclusions:
Huangqi may play a therapeutic role in treating COVID-19 with myocardial injury
by the effects of resisting virus and protecting myocardium concurrently.
Ferroptosis Inhibitors as New Therapeutic Insights into Radiation-Induced Heart Disease
Authors: Shaghaghi Zahra , Farzipour Soghra , Jalali Fatemeh , Alvandi Maryam 
Published: July 2022

Abstract:
Radiation-induced heart disease (RIHD) is a significant cause of morbidity in breast
and other mediastinal cancers. The many molecular and cellular patho-mechanisms that have a
role in RIHD are not completely understood. Endothelial injury, oxidative stress, and inflammation,
as well as endoplasmic reticulum and mitochondrial damage, are considered the primary
causes of RIHD. Ferroptosis is a newly discovered type of cell death that results from irondependent
lipid peroxide accumulation. As ferroptosis plays an important role in the
pathogenesis of cardiovascular diseases, it seems that it has a significant effect on RIHD. It was
recently shown that ionizing radiation (IR) generates severe ferroptosis, which is a critical component
of Radiotherapy-mediated normal cell toxicity. These findings support the use of a ferroptosis
inhibitor to reduce RIHD. In this perspective review, we summarize the role of
ferroptosis in pathogens of cardiovascular disease and radiation toxicity, and we will introduce
ferroptosis inhibitors as a new strategy to prevent or reduce RIHD.
The Relationship Between Incidence of Depression After Myocardial Infarction (MI)
Authors: Gheini Alireza , Pooria Ali , Pourya Afsoun , Farokhi Ermia 
Published: July 2022

Objective:
Depression is predicted to be the leading cause of mortality and morbidities in the next few years. Its association with cardiovascular diseases is well-established from various researches. The aim of this study is to evaluate the incidence of depression of co-morbid psychiatric disorders among patients with a recent history of myocardial infarction (MI).

Methods:
In this retrospective study, patients with a history of myocardial infarction marked by electrocardiographic (ECG) and enzymatic findings referred to our psychiatric center were included. The MMPI questionnaire was used to evaluate the prevalence of depression along with other psychiatric disorders. SPSS v18 was used to evaluate the data recorded and analyzed from these questionnaires.

Results:
Of 50 patients studied, the prevalence of depression is the greatest (63%) in patients with anterior septal MI. Furthermore, 26% of women and 24% of men with depression and hysteria were the common comorbidity reported. To it, 15 patients aged 60-69 years had post-MI depression.

Conclusion:
Our study reports an increased incidence of post-MI depression in the general targeted population. Further investigation and therapeutic measures can decrease future repercussions and the incidence of other cardiovascular events, including recurrent MI.
Collaborative Practices in Early Childhood Intervention: the case for explicitly striving for maximal participation of families
Authors: Ribeiro Lage Carla , Snider Jacqui 
Published: July 2022

Early Childhood Intervention aims to empower parents and children to become confident and competent in independently finding solutions to everyday life challenges. Therapists have only the best intentions in their practice; however, in their eagerness to help, they may be unknowingly disempowering parents when taking ownership of the intervention. The purpose of this opinion paper is to encourage and inspire therapists to pause, reflect, and reconsider the significance of parent-therapist partnerships and the use of a coach approach for implementing Family-Centred Best Practice. Based on clinical and research experiences in Early Childhood Intervention, the authors believe that therapists need to further develop communication and interpersonal skills so that they can empower parents in the same way they empower children. When therapists are trained to implement collaborative practices, they may feel less pressure to have all the answers and be primarily responsible for supporting children's development and functioning. Collaborative practices such as coaching can help therapists establish a respectful, equitable, and complementary partnership with parents, transforming “power over” relationships into “power with” relationships. This change can be more rewarding and satisfying for everyone involved. Providing best practice interventions often requires therapists to constantly focus on their therapeutic expertise. Yet, the effectiveness of interventions for children and their families can also be significantly improved if therapists refine how they deliver their services. Parents play a key role in the successful intervention of their children; therefore, to achieve sustainable long-term therapy goals, it is necessary to understand how to communicate with, relate to, and coach parents effectively.
Virtual ER, a Serious Game for Interprofessional Education to Enhance Teamwork in Medical and Nursing Undergraduates: Development and Evaluation Study
Authors: Wong Janet Yuen-Ha , Ko Joanna , Nam Sujin , Kwok Tyrone , Lam Sheila , Cheuk Jessica , Chan Maggie , Lam Veronica , Wong Gordon T C , Ng Zoe L H , Wai Abraham Ka-Chung 
Published: July 2022

Background
Engaging students in interprofessional education for higher order thinking and collaborative problem-solving skills is challenging. This study reports the development of Virtual ER, a serious game played on a virtual platform, and how it can be an innovative way for delivering interprofessional education to medical and nursing undergraduates.

Objective
We report the development of a serious online game, Virtual ER, and evaluate its effect on teamwork enhancement and clinical competence. We also explore if Virtual ER can be an effective pedagogical tool to engage medical and nursing students with different learning styles.

Methods
Virtual ER is a custom-made, learning outcome–driven, case-based web app. We developed a game performance scoring system with specific mechanisms to enhance serious gaming elements. Sixty-two students were recruited from our medical and nursing programs. They played the games in teams of 4 or 5, followed by an instructor-led debriefing for concept consolidation. Teamwork attitudes, as measured by the Human Factors Attitude Survey, were compared before and after the game. Learning style was measured with a modified Honey and Mumford learning style questionnaire.

Results
Students were satisfied with Virtual ER (mean satisfaction score 5.44, SD 0.95, of a possible 7). Overall, Virtual ER enhanced teamwork attitude by 3.02 points (95% CI 1.15-4.88, P=.002). Students with higher scores as activists (estimate 9.09, 95% CI 5.17-13.02, P<.001) and pragmatists (estimate 5.69, 95% CI 1.18-10.20, P=.01) had a significantly higher degree of teamwork attitude enhancement, while students with higher scores as theorists and reflectors did not demonstrate significant changes. However, there was no difference in game performance scores between students with different learning styles.

Conclusions
There was considerable teamwork enhancement after playing Virtual ER for interprofessional education, in particular for students who had activist or pragmatist learning styles. Serious online games have potential in interprofessional education for the development of 21st century life skills. Our findings also suggest that Virtual ER for interprofessional education delivery could be expanded locally and globally.
Removal of Uremic Solutes from Dialysate by Activated Carbon
Authors: Lee Seolhyun , Sirich Tammy L. , Blanco Ignacio J. , Plummer Natalie S. , Meyer Timothy W. 
Published: July 2022

Background and objectives
Adsorption of uremic solutes to activated carbon provides a potential means to limit dialysate volumes required for new dialysis systems. The ability of activated carbon to take up uremic solutes has, however, not been adequately assessed.

Design, setting, participants, & measurements
Graded volumes of waste dialysate collected from clinical hemodialysis treatments were passed through activated carbon blocks. Metabolomic analysis assessed the adsorption by activated carbon of a wide range of uremic solutes. Additional experiments tested the ability of the activated carbon to increase the clearance of selected solutes at low dialysate flow rates.

Results
Activated carbon initially adsorbed the majority, but not all, of 264 uremic solutes examined. Solute adsorption fell, however, as increasing volumes of dialysate were processed. Moreover, activated carbon added some uremic solutes to the dialysate, including methylguanidine. Activated carbon was particularly effective in adsorbing uremic solutes that bind to plasma proteins. In vitro dialysis experiments showed that introduction of activated carbon into the dialysate stream increased the clearance of the protein-bound solutes indoxyl sulfate and p-cresol sulfate by 77%±12% (mean±SD) and 73%±12%, respectively, at a dialysate flow rate of 200 ml/min, but had a much lesser effect on the clearance of the unbound solute phenylacetylglutamine.

Conclusions
Activated carbon adsorbs many but not all uremic solutes. Introduction of activated carbon into the dialysate stream increased the clearance of those solutes that it does adsorb.
Un estudio sobre el autoliderazgo, la autoeficacia emprendedora y la innovación en la generación de los Centennials en estudiantes de la FESC
Authors: Herrera-Laguna Victoria-Yamileth , Sanchez Mojica Karla Yohana , Guzmán-Soria Eugenio 
Published: July 2022

En la actualidad el percibir lo que los empleados actuales y futuros consideran más importante puede ser difícil cuando esas expectativas están cambiando por la globalización, la competitividad y el mismo mercado, el sector empresarial se ha visto afectado. Por lo cual, la población objetivo fueron los universitarios pertenecientes a una generación conocida como Centennials o Z, quienes buscan nuevas tendencias, ambientes e independencia laboral, por lo que muchos de ellos emprenden. El presente trabajo validó la influencia de tres variables: autoliderazgo, autoeficacia emprendedora y la innovación en estudiantes de la Fundación de Estudios Superiores Comfanorte en Colombia, obteniendo resultados preliminares empleando el software de análisis estadístico (SmartPLS).
Mucormycosis in patients with COVID-19 in Russia: the results of a prospective multi-center study
Authors: Khostelidi S. N. , Zaytsev V. A. , Vartanyan S. A. , Nikitin N. A. , Evtukh G. N. , Gilalov M. N. , Portnov G. V. , Zubareva A. A. , Baranova I. B. , Bogomolova T. S. , Avdeenko Yu. L. , Shadrivova O. V. , Desyatik E. A. , Shagdileeva E. V. , Borzova Yu. V. , Krivolapov Yu. A. , Vasilyeva N. V. , Klimko N. N. 
Published: July 2022

We present the results of a prospective multicenter study of risk factors, etiology, clinical features, and treatment outcomes for mucormycosis in patients with COVID-19 (COVID-M) in the Russian Federation.The study included 60 adult patients with COVID-M. To analyze risk factors for COVID-M, we conducted a case-control study. The control group included 60 adult patients with COVID-19 without mucormycosis. To analyze the clinical manifestations of COVID-M, we created a control group of hematological patients with mucormycosis examined in 2011–2020.In patients with COVID-19, the risk of developing mucormycosis was significantly increased with diabetes mellitus (OR=49) and overweight (OR=4,75), as well as with the use of high (≥100 mg per day for prednisolone) doses of glucocorticosteroids (OR= 4,762), especially ≥10 days (OR=25,4). The main localization of mucormycosis in patients with COVID-19 was the paranasal sinuses (95%) and the orbit (68%). Involvement of ≥2 organs was identified in 70% of patients. The main causative agents of mucormycosis were Rhizopus arrhizus (43%) and unidentified mucormycetes (36%).90-days overall survival of patients with mucormycosis and COVID-19 – 71%. The stay in the ICU (p=0,01), the use of mechanical ventilation (p=0,0481), the presence of CVC (p=0,049), CNS damage (p=0,016) and ≥ 2 organs (p=0,048) significantly worsened the prognosis of the disease. The best prognosis was in patients who received antifungal therapy (p=0,03875) and surgical treatment (p=0,046).
Efficacy and safety of vector vaccines for the prevention of new coronavirus infection
Authors: Kharit S. M. , Fridman I. V. 
Published: July 2022

The review article discusses vaccines against SARS-CoV 2 based on adenovirus vectors currently used in the world. The concept of creating vector vaccines is described. The data of clinical studies on the efficacy and safety of registered adenovirus-vector vaccines for the prevention of new coronavirus infection are presented. The frequency of serious adverse events after their use is described in detail. In addition, the clinical efficacy of vector vaccines for changing genotypes of the Covid 19 virus has been determined.The review analyzes literature data on the safety and efficacy of vector vaccines against coronavirus infection.The vector vaccines currently used against the new coronavirus infection are quite safe and effective even in relation to the new genotypes of the SARS-CoV 2 virus.
The state of the cardiovascular system in typhoid fever (Experience of a leading infectious disease specialist of a limited contingent of Soviet troops in Afghanistan)
Authors: Ljashenko Yu. I. 
Published: July 2022

In order to clarify the frequency and duration of changes in the functional state of the cardiovascular system in typhoid patients, as well as the definition of the structure and features of injuries in modern conditions, the medical records of 286 patients were analysed retrospectively, including 36 persons with a fatal outcome among members of a limited contingent of Soviet troops in Afghanistan (1983–1985). The results of the tests in the deceased were compared to the autopsy of the tissues of their bodies.The nature of the changes in the indicators of the functional state of the cardiovascular system during various periods of light, medium, heavy and extremely severe forms of typhoid fever and their diagnostic informativeness, structure, as well as the frequency of registration are explained, features of clinical and morphological manifestations of infectious toxicity shock, thrombohemorrhagic syndrome, myocardial dystrophy, infectious toxicity myocarditis, as well as the significance of pre-mortem status in this disease. It has been established that patients with an extremely severe form of relapse of typhoid in connective tissue develop in the intercardiomyocytic intervals.
Infectious endocarditis in HIV-infected intensive care unit patients
Authors: Kharlamova T. V. , Voznesenskiy S. L. , Ermak T. N. , Kozhevnikova G. M. , Klimkova P. V. 
Published: July 2022

Infective endocarditis (IE) is one of the most common cardiac complications in HIV patients who are intravenous drug addicts. The presence of IE and secondary diseases in immunocompromised individuals usually requires specific diagnostic and therapeutic approach.Aim: Optimizing the diagnosis of IE in patients with advanced HIV/AIDS.Materials and methods We reviewed 429 case records of HIV/AIDS ICU patients using the modified duke criteria for diagnosis of infective endocarditis. Statistical significance (p <0.05) of data was assessed using the χ2 test.Results. 25 patients were diagnosed with IE. The male gender dominated – 68%. Mean age was 38. 60% had stage 4B HIV infection. 68% were ART naive. The medium viral load was 294560 copies / ml, while the medium CD4 count was 218 cells / μl. Fever of >38°C was a key symptom found in all patients. Blood cultures were positive in 60% cases. 80% had a high C reactive protein (CRP), and 44% had CRP levels above 100 mg/l. Procalcitonin (PCT) levels were increased in 52%. Echocardiogram revealed IE in 92%. Pneumonia was diagnosed in 92%. Fatal outcome occurred in 76%. Anemia was a predictor of severe outcome (p<0.002), while patients with leukocytosis had good prognosis (p<0.05).Conclusion. Infective endocarditis is a common complication among HIV IDUs. The most common diagnostic criteria are fever >38°C, pneumonia, anemia, leukocytosis, thrombocytopenia and echocardiographic findings. The levels of the hemoglobin and WBCs could evaluate prognosis of the disease outcome.