bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconfigurable System-on-Chip Architectures for Robust Visual SLAM on Humanoid Robots
Authors: Gkeka Maria Rafaela , Patras Alexandros , Tavoularis Nikolaos , Piperakis Stylianos , Hourdakis Emmanouil , Trahanias Panos , Antonopoulos Christos D. , Lalis Spyros , Bellas Nikolaos 
Published: November 2022

Visual Simultaneous Localization and Mapping (vSLAM)is the method of employing an optical sensor to map the robot’s observable surroundings while also identifying the robot’s pose in relation to that map. The accuracy and speed of vSLAM calculations can have a very significant impact on the performance and effectiveness of subsequent tasks that need to be executed by the robot, making it a key building component for current robotic designs. The application of vSLAM in the area of humanoid robotics is particularly difficult due to the robot’s unsteady locomotion. This paper introduces a pose graph optimization module based on RGB (ORB) features, as an extension of the KinectFusion pipeline (a well-known vSLAM algorithm), to assist in recovering the robot’s stance during unstable gait patterns when the KinectFusion tracking system fails. We develop and test a wide range of embedded MPSoC FPGA designs, and we investigate numerous architectural improvements, both precise and approximation, to study their impact on performance and accuracy. Extensive design space exploration reveals that properly designed approximations, which exploit domain knowledge and efficient management of CPU and FPGA fabric resources, enable real-time vSLAM at more than 30 fps in humanoid robots with high energy-efficiency and without compromising robot tracking and map construction. This is the first FPGA design to achieve robust, real-time dense SLAM operation targeting specifically humanoid robots. An open source release of our implementations and data can be found in [1].
Attacking DoH and ECH: Does Server Name Encryption Protect Users’ Privacy?
Authors: Trevisan Martino , Soro Francesca , Mellia Marco , Drago Idilio , Morla Ricardo 
Published: November 2022

Privacy on the Internet has become a priority, and several efforts have been devoted to limit the leakage of personal information. Domain names, both in the TLS Client Hello and DNS traffic, are among the last pieces of information still visible to an observer in the network. The Encrypted Client Hello extension for TLS, DNS over HTTPS or over QUIC protocols aim to further increase network confidentiality by encrypting the domain names of the visited servers.
In this article, we check whether an attacker able to passively observe the traffic of users could still recover the domain name of websites they visit even if names are encrypted. By relying on large-scale network traces, we show that simplistic features and off-the-shelf machine learning models are sufficient to achieve surprisingly high precision and recall when recovering encrypted domain names. We consider three attack scenarios, i.e., recovering the per-flow name, rebuilding the set of visited websites by a user, and checking which users visit a given target website. We next evaluate the efficacy of padding-based mitigation, finding that all three attacks are still effective, despite resources wasted with padding. We conclude that current proposals for domain encryption may produce a false sense of privacy, and more robust techniques should be envisioned to offer protection to end users.
Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer
Authors: Chou Jonathan , Egusa Emily A. , Wang Sinan , Badura Michelle L. , Lee Fei , Bidkar Anil P. , Zhu Jun , Shenoy Tanushree , Trepka Kai , Robinson Troy M. , Steri Veronica , Huang Jiaoti , Wang Yuzhuo , Small Eric J. , Chan Emily , Stohr Bradley A. , Ashworth Alan , Delafontaine Brant , Rottey Sylvie , Cooke Keegan S. , Hashemi Sadraei Nooshin , Yu Brian , Salvati Mark , Bailis Julie M. , Feng Felix Y. , Flavell Robert R. , Aggarwal Rahul 
Published: November 2022

Abstract

Effective treatments for de novo and treatment-emergent small-cell/neuroendocrine (t-SCNC) prostate cancer represent an unmet need for this disease. Using metastatic biopsies from patients with advanced cancer, we demonstrate that delta-like ligand 3 (DLL3) is expressed in de novo and t-SCNC and is associated with reduced survival. We develop a PET agent, [89Zr]-DFO-DLL3-scFv, that detects DLL3 levels in mouse SCNC models. In multiple patient-derived xenograft models, AMG 757 (tarlatamab), a half-life–extended bispecific T-cell engager (BiTE) immunotherapy that redirects CD3-positive T cells to kill DLL3-expressing cells, exhibited potent and durable antitumor activity. Late relapsing tumors after AMG 757 treatment exhibited lower DLL3 levels, suggesting antigen loss as a resistance mechanism, particularly in tumors with heterogeneous DLL3 expression. These findings have been translated into an ongoing clinical trial of AMG 757 in de novo and t-SCNC, with a confirmed objective partial response in a patient with histologically confirmed SCNC. Overall, these results identify DLL3 as a therapeutic target in SCNC and demonstrate that DLL3-targeted BiTE immunotherapy has significant antitumor activity in this aggressive prostate cancer subtype.

Significance:
The preclinical and clinical evaluation of DLL3-directed immunotherapy, AMG 757, and development of a PET radiotracer for noninvasive DLL3 detection demonstrate the potential of targeting DLL3 in SCNC prostate cancer.
Association of Urinary Biomarkers of Smoking-Related Toxicants with Lung Cancer Incidence in Smokers: The Multiethnic Cohort Study
Authors: Cigan Shannon S. , Murphy Sharon E. , Stram Daniel O. , Hecht Stephen S. , Marchand Loïc Le , Stepanov Irina , Park Sungshim L. 
Published: November 2022

AbstractBackground:While cigarette smoking is the leading cause of lung cancer, the majority of smokers do not develop the disease over their lifetime. The inter-individual differences in risk among smokers may in part be due to variations in exposure to smoking-related toxicants.Methods:Using data from a subcohort of 2,309 current smokers at the time of urine collection from the Multiethnic Cohort Study, we prospectively evaluated the association of ten urinary biomarkers of smoking-related toxicants [total nicotine equivalents (TNE), a ratio of total trans-3′-hydroxycotinine (3-HCOT)/cotinine (a phenotypic measure of CYP2A6 enzymatic activity), 4-(methylnitrosamino)-1–3-(pyridyl)-1-butanol (NNAL), S-phenylmercapturic acid (SPMA), 3-hydroxypropyl mercapturic acid (3-HPMA), phenanthrene tetraol (PheT), 3-hydroxyphenanthrene (PheOH), the ratio of PheT/PheOH, cadmium (Cd), and (Z)-7-(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopenyl]hept-5-enoic acid (8-iso-PGF2α)] with lung cancer risk (n = 140 incident lung cancer cases over an average of 13.4 years of follow-up). Lung cancer risk was estimated using Cox proportional hazards models.Results:After adjusting for decade of birth, sex, race/ethnicity, body mass index, self-reported pack-years, creatinine, and urinary TNE (a biomarker of internal smoking dose), a one SD increase in log total 3-HCOT/cotinine (HR, 1.33; 95% CI, 1.06–1.66), 3-HPMA (HR, 1.41; 95% CI, 1.07–1.85), and Cd (HR, 1.45; 95% CI, 1.18–1.79) were each associated with increased lung cancer risk.Conclusions:Our study demonstrates that urinary total 3-HCOT/cotinine, 3-HPMA, and Cd are positively associated with lung cancer risk. These findings warrant replication and consideration as potential biomarkers for smoking-related lung cancer risk.Impact:These biomarkers may provide additional information on lung cancer risk that is not captured by self-reported smoking history or TNE.See related commentary by Etemadi et al., p. 289
Human Bone Marrow Organoids for Disease Modeling, Discovery, and Validation of Therapeutic Targets in Hematologic Malignancies
Authors: Khan Abdullah O. , Rodriguez-Romera Antonio , Reyat Jasmeet S. , Olijnik Aude-Anais , Colombo Michela , Wang Guanlin , Wen Wei Xiong , Sousos Nikolaos , Murphy Lauren C. , Grygielska Beata , Perrella Gina , Mahony Christopher B. , Ling Rebecca E. , Elliott Natalina E. , Karali Christina Simoglou , Stone Andrew P. , Kemble Samuel , Cutler Emily A. , Fielding Adele K. , Croft Adam P. , Bassett David , Poologasundarampillai Gowsihan , Roy Anindita , Gooding Sarah , Rayes Julie , Machlus Kellie R. , Psaila Bethan 
Published: November 2022

Abstract

A lack of models that recapitulate the complexity of human bone marrow has hampered mechanistic studies of normal and malignant hematopoiesis and the validation of novel therapies. Here, we describe a step-wise, directed-differentiation protocol in which organoids are generated from induced pluripotent stem cells committed to mesenchymal, endothelial, and hematopoietic lineages. These 3D structures capture key features of human bone marrow—stroma, lumen-forming sinusoids, and myeloid cells including proplatelet-forming megakaryocytes. The organoids supported the engraftment and survival of cells from patients with blood malignancies, including cancer types notoriously difficult to maintain ex vivo. Fibrosis of the organoid occurred following TGFβ stimulation and engraftment with myelofibrosis but not healthy donor–derived cells, validating this platform as a powerful tool for studies of malignant cells and their interactions within a human bone marrow–like milieu. This enabling technology is likely to accelerate the discovery and prioritization of novel targets for bone marrow disorders and blood cancers.

Significance:
We present a human bone marrow organoid that supports the growth of primary cells from patients with myeloid and lymphoid blood cancers. This model allows for mechanistic studies of blood cancers in the context of their microenvironment and provides a much-needed ex vivo tool for the prioritization of new therapeutics.
See related commentary by Derecka and Crispino, p. 263.
This article is highlighted in the In This Issue feature, p. 247
Bodies of Knowledge in Philostratus’ Life of Apollonius
Authors: Kelting Edward 
Published: November 2022

Abstract
Philostratus’ Life of Apollonius uses the transmigration of the soul to tie the present to the past through corporal metaphors of cultural preservation. These metaphors are laced throughout Apollonius’ visits to Indian Brahmans and Ethiopian naked sages (Gymnoi), two wisdom groups who respectively celebrate and deny the embodied knowledge of the past that reincarnation allows. This somatic line of thinking culminates in a debate over the Gymnoi’s eponymous nudity, which Apollonius critiques on two counts: it wrongly suggests that the Gymnoi can divest themselves of their past and creates a false dichotomy between clothes and body, ornament and essence.
The Syntax-Morphology Interface in Ancient Greek
Authors: Asraf Nadav 
Published: November 2022

Abstract
Even though syntax and morphology are generally taken to be distinct components of language, two morphological structures in Ancient Greek—denominal adjectives and compounds—possess syntactical properties in that their morphemes, rather than the whole words, participate in select syntactical processes. These phenomena, occurring at the boundary between syntax and morphology, ostensibly violate the generative Lexical Integrity Principle. Nonetheless, instances of such phenomena can be found in various Ancient Greek sources. These instances, traditionally treated as ad sensum constructiones or as syntactical mishaps, are not bereft of internal consistency, and in fact form their own well-organized subsystem and even obey an implicational hierarchy.
The diurnal advertisement and response call of Pulchrana glandulosa (Anura: Ranidae) (Boulenger, 1882), from Langkawi Island, Kedah, Peninsular Malaysia
Authors: Ong Dasi , Shahrudin Shahriza 
Published: November 2022

Abstract
Most of Malaysian’s anuran species are nocturnally active, including Pulchrana glandulosa. However, all the studies on the description of this species’ call were done during nocturnal surveys in Sarawak, Borneo. Here we report the diurnal call of this frog from Langkawi Island, Kedah, Peninsular Malaysia. This male frog exhibits two types of calls: repetitive one-note advertisement calls and multiple-note response calls. Anuran bioacoustics can use to monitor the well-being of the environment they occupy. This information is very informative for the conservation management authority and decision-making for conservation purposes. The diurnal call of this frog is a rare discovery and was not yet described in previous records. This research shows us that this frog calls diurnally and nocturnally because its skin secretion has a high toxicity level. Besides that, this frog is well known for its loud “WAHK” call at night. However, the diurnal call is not as rare as one thinks; we need to know the specific spot at a specific time of occurrence. Furthermore, these surveys also need to be done diurnally to minimise the undetected species behaviour as in this study, which is essential for our scientific community.
Marxist Analysis of Alienation (1973)
Authors: Sève Lucien 
Published: November 2022

Abstract
Lucien Sève (1926–2020) was one of the foremost Marxist theoreticians of the Parti Communiste Français. An indomitable opponent of both structural and humanist Marxism, his 1973 article reprinted below represents the core of his conception of alienation. For Sève, whilst the mature Marxism of Das Kapital is fundamentally distinct from the speculative humanism of the 1844 Manuscripts in placing capital, not abstract labour, at the heart of alienation, this reinforces, rather than replaces, the role of alienation at the centre of Marx’s mature thought, and hence of Marxism itself.
La mémoire d’al-Ḥīra et la notice de ʿAdī b. Zayd dans le Kitāb al-Aġānī au regard des sources tardo-antiques et médiévales
Authors: Croq Alice , Brelaud Simon 
Published: November 2022

Résumé
L’étude vise à retracer le milieu de production des histoires de ʿAdī b. Zayd, poète « chrétien » d’al-Ḥīra, et de sa famille, en comparant la version fournie dans le Kitāb al-Aġānī aux autres traditions historiographiques tardo-antiques et médiévales, d’une part, et en soumettant cette version à la critique textuelle et littéraire, d’autre part. Les résultats permettent de défendre l’hypothèse que ces histoires auraient été élaborées à al-Ḥīra, entre 602 et 633 ap. J.-C., afin d’affirmer la légitimité de la famille des Banū Ayyūb à dominer la ville. L’enquête montre aussi que le Kitāb al-Aġānī est un témoin précieux de la circulation de l’information entre milieux chrétiens et musulmans en Mésopotamie durant les premiers siècles de l’islam.
Christianity, Personality and Environmental Concern among 13- to 15-year-old Students in England and Wales
Authors: Francis Leslie J. , Walker David S. , Village Andrew 
Published: November 2022

Abstract
This study explores the connection between Christianity and environmental concern among a sample of 23,714 13- to 15-year-old students (who self-identify as Christian or self-identify as no religion) employing three scales of Attitude toward Christianity, Conservative Christian Belief, and Environmental Concern and Behaviour, together with measures of personality, church attendance, and personal prayer. The key findings are that: religious behaviours, church attendance and personal prayer, are significant predictors, with churchgoing and praying students holding higher levels of environmental concern and behaviour; religious affect is more significant than religious behaviours, with a positive attitude toward Christianity accounting for greater variance than churchgoing and prayer in predicting higher levels of environmental concern and behaviour; conservative Christian belief is associated with lower levels of environmental concern and behaviour (after taking into account religious practice and religious affect); and nominal Christian affiliation is associated with lower levels of environmental concern and behaviour.
Romancing the Nation
Authors: Aldoughli Rahaf 
Published: November 2022

Abstract
Spanning the era of the two Assads (father and son) up to 2007 (the referendum year confirming Bashar al-Assad’s continuation as president) and songs produced during the war, this study will explore the role of ‘love’ (hub) and its relation to ‘blood’ (dam) in the continuity and persistence of heroism in the national narrative. As a form of politics, love and blood have served the Baathist state in obtaining and using power and domination. This article investigates the various ways love as a political tool has been instrumentalized to legitimize the regime and construct national ties and unity. As such, this study interrogates the connection between the sacralization of the nation and the construction of love as a political and cultural tool to subject loyalty and subordination in political culture. Understanding discursive appropriations of love in this way offers a fresh perspective into the meaning—and most importantly, the politics—of love in modern Syria and its relation to Baathism, the Syrian uprising, and popular culture. In this context, the use of the term ‘love’ (hub) by the opposition has become a confirmatory tool of the regime’s illegitimacy. While ‘love’ as a political tool has been instrumentalized by the Syrian Baath regime to consolidate authority, the citizenry now faces many challenges. One of these is not only reversing this imposed ‘love’ with hate or anger towards the regime, but more importantly, rationalizing nationhood and national membership by focusing on establishing civic engagement and representation.
‘Rojava’: Evolving Public Discourse of Kurdish Identity and Governance in Syria
Authors: McGee Thomas 
Published: November 2022

Abstract
The Syrian conflict has contributed to major debates in culture, media and politics around transitions linked to borders, ethnicity and identity. Against this backdrop, this article explores the use of ‘Rojava’, a keyword referring to Kurdish-majority areas in the country. It examines the term’s changing meanings and usage against the evolving backdrop of the governance project led by Kurds since the post-2011 power vacuum in North(eastern) Syria. The article identifies how the term has been both operationalized and later abandoned and replaced by other nomenclature while highlighting the implications of these changes on public and political discourse. The term ‘Rojava’ traces its origins to the context of (pan-)Kurdish nationalism, with its literal meaning of ‘western’ (Kurdistan) implying a notion of trans-border Kurdish identity. From this point of departure, the author considers how it has been popularized in anarchist and Western solidarity circles as well as through international media in expressions such as the ‘Rojava experiment’ and ‘Rojava Revolution’. The article unpacks how it has become shorthand in Western media for an ideology of women’s liberation and leftist grassroots governance, as well as considering the term’s less favorable reception in the Arab press, where the word ‘Rojava’ itself is treated as a foreign, and sometimes threatening, concept. Finally, the article presents how from 2016 the Kurdish-led authorities in this region of Syria sought to formally distance themselves from the term they had introduced. This change was due to realpolitik imperatives to re-brand their governance project under the ‘Syrian Democratic’ banner when incorporating non-Kurdish-majority territories (Raqqa, Deir ez-Zor and Menbij). In the context of its official abandonment, the term has nonetheless retained currency in the media as well as popular everyday contexts among Kurds on street level.
Partial Implementation of Migrant Rights Protection? Indonesia’s Short-Sighted Approach towards Foreign Migrant Workers
Authors: Setiawan Whisnu , Karim Moch Faisal 
Published: November 2022

Abstract
This article examines the disparity between Indonesia’s efforts to protect its migrant workers abroad with its efforts to ensure the rights of migrant workers within its borders. As a state party to the International Convention on the Protection of the Rights of All Migrant Workers and Members of Their Families (ICRMW), Indonesia is obliged to uphold the rights of migrant workers regardless of their migratory pattern. Despite its efforts to protect Indonesian migrant workers abroad, it often seems to neglect its obligation to enforce migrant workers’ rights at home. This article will show how the state-sanctioned mechanisms to settle labor disputes between foreign migrant workers and employers are generally designed to benefit the latter. These mechanisms usually focus on the legality of the workers to determine to which rights they are entitled, if any. Furthermore, the absence of support from Indonesia in enforcing other migrant workers’ rights at ASEAN regional platforms reinforces this short-sighted approach of defining migrant workers exclusively as Indonesians overseas, while overlooking its obligations to migrant workers within Indonesia.
An Integrated Research Plan for the Tibetan Plateau Land–Air Coupled System and Its Impacts on the Global Climate
Authors: Wu Guoxiong , Zhou Xiuji , Xu Xiangde , Huang Jianping , Duan Anmin , Yang Song , Hu Wenting , Ma Yaoming , Liu Yimin , Bian Jianchun , Fu Yunfei , Yang Haijun , Zhao Ping , Zhong Lei , Ma Weiqiang 
Published: November 2022

Abstract
The unique characteristics of land–air coupling and troposphere–stratosphere interaction over the Tibetan Plateau (TP), the highest landform in the world, play a vital role in weather and climate on regional and global scales. Although a great deal of research has been carried out, large gaps remain in our understanding of TP land–air coupling and its climate effects, due to a lack of observations and the issue of model biases. To address these obstacles, a 10-yr national research program entitled “Changes in the Land–Air Coupled System over the Tibetan Plateau and its Impacts on Global Climate (LASTPIC)” was launched by the National Natural Science Foundation of China in January 2014. What LASTPIC does revolves around three aspects: TP land–air coupled processes; TP’s influence on global climate; and reanalysis and model. This paper mainly focuses on the data collection, scientific understanding, and model development of LASTPIC in terms of TP land–atmosphere–ocean coupling and its global climate impacts since program’s inception.