bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lima Bean International Network: From the origin to the plant breeding
Authors: Martínez-Castillo Jaime , Araujo Ademir S. F. , Chacón-Sánchez María I. , Santos Luis G. , Lopes Angela C. A. , Gibson Kimberly , Gomes Regina L. F. , Andueza-Noh Rubén H. , Bitochi Elena , Ballina-Gómez Horacio S. , Peralta Eduardo , Ormeño-Orrillo Ernesto , Espinoza Luz , Nieto Carlos , Murillo Angel , Jadán-Veriñas Eudaldo , García Tatiana , Duitama Jorge , Aguirre-Liguori Jonás A. , León-Cadena Andrea , Castañeda-Alvarez Nora , Debouck Daniel G. 
Published: December 2022

Abstract
Lima bean (Phaseolus lunatus L.) is the second most important domesticated species of Phaseolus in the world and could represent a precious alternative for food security and quality, as well as play a major role for sustainability in the face of climate change in Latin America and worldwide. Currently, many experts on conservation, domestication, genetic improvement, and plant-rhizosphere relationship of Lima bean have been working alone or in small groups. This situation has limited obtaining a greater benefit from their research and strongly prompts the study of the Lima bean worldwide. To increase the collaboration between experts in the study of the Lima bean, we present the Lima Bean International Network (LBIN). The main objectives of LBIN are to deepen the knowledge on this species and to promote its use worldwide. The success of LBIN will depend on the collaboration of the international scientific community interested in the study of Lima bean. Hence, we invite people from different sectors of society (researchers, producers, companies, NGOs, governments) to participate in this initiative. To get more information, you can visit https://www.cicy.mx/sitios/red-internacional-frijol-lima
The Impact of Traumatic Brain Injury on Mental Health Care Utilization: A Propensity Matched Analysis of National Data
Authors: Kureshi Nelofar , Clarke David B. , Feng Cindy 
Published: December 2022

Abstract
Background: Mental health disorders are a common sequelae of traumatic brain injury (TBI) and are associated with worse health outcomes including increased mental health care utilization. This study addresses the methodical limitations of previous studies by examining the effect of TBI on mental health care utilization using propensity score matching analysis.
Methods: Using data from a national survey, this study assessed mental health care utilization among those with a TBI, compared with a non-injured control group. Propensity score matching for age, sex, education, income, marital status, race, mental health comorbidities, and chronic conditions in a 4:1 ratio using nearest neighbor was performed. Conditional logistic regression then compared matched patients in terms of mental health care utilization. E-value sensitivity analysis was used to assess how strong an unmeasured confounder would have to be to explain away an observed relationship.
Results: The matched study sample included 76,727 TBI patients and 307,510 non-injured controls with significantly improved balance in all baseline covariates. After conditional regression of the propensity-matched cohort, TBI remained a significant predictor of mental health care utilization (95% CI, 1.38-3.67), showing a 2.25-fold increased probability of mental health care utilization in TBI patients.
Conclusions: This study is the first to evaluate the probability of mental health care utilization in TBI patients through a well-matched national cohort. TBI patients were more than twice as likely to use health care services for mental health complaints relative to those who were uninjured. Further longitudinal research is needed to evaluate the long-term mental health care utilization of TBI patients.
Parameter Optimization of Gas Metal Arc Welding Process for Welding Dissimilar Steels
Authors: Tesfaye Fasil Kebede 
Published: December 2022

Abstract
This work attempts to optimize the welding process parameters for a dissimilar metal joint made of duplex stainless steel (DSS) to grade ASTM/UNS S32205 and weathering steel CORTEN-A to grade ASTM A242. Such a dissimilar metal joint finds use in the transportation sector, particularly in the construction of rail cars. The study has taken into account the square butt joint between 2 mm thick sheets welded using the gas metal arc welding (GMAW) process with CO2 as the shielding gas and flux cored wire of grade 309L as the filler material. The tensile strength of the resulting weld joint, which was the desired quality characteristic, was optimized using the L9 Taguchi array. For optimization, GMAW process parameters like voltage, wire feed rate, and welding speed at three levels are taken into account. Using ANOVA, the effects of each factor have been studied. It was found that the ideal set of parameters exists, and that the voltage is the most crucial factor. A confirmation test was carried out to verify the results, and it was wrapped up with a figure and tables.
Predictive value of properties of resected parathyroid glands for persistent secondary hyperparathyroidism during parathyroidectomy
Authors: Huang Yaoyu , Wang Jing , Zeng Ming , Wan Huiting , Wang Ningning , Yang Guang 
Published: December 2022

Abstract
Background
Parathyroidectomy (PTX), an effective treatment for refractory secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) patients, still has a high persistent rate. This study aimed to analyse the predictive value of properties of resected parathyroid glands for postoperative persistent SHPT.
Methods
The clinical data of 267 patients (62 persistent SHPT patients and 165 successful PTX controls) who received total parathyroidectomy with forearm autotransplantation (TPTX + AT) was retrospectively collected. The properties including the number, minimum weight, maximum weight and total weight of resected parathyroid glands from each patient were recorded. Properties and cutoff value of resected parathyroid glands for the prediction of persistent SHPT were analysed.
Results
41 (66.13%) persistent SHPT cases related to supernumerary parathyroid and the remaining 21 (33.87%) cases related to residual undetected parathyroid. In addition, ectopic parathyroid was found in 8 patients (12.90%) before PTX. The averages of resected glands in the persistent SHPT group and in the successful PTX group were 3.53 ± 0.72 and 3.93 ± 0.25 respectively (t = 4.302, p < 0.001). There was significance in the number of patients who had 2, 3, and 4 glands resected between two groups (χ2 = 33.891, p < 0.001). The number of removed glands fewer than 4 might increase the risk of persistent SHPT. When the resected gland number was 4, minimum weight of the parathyroid was noted to be heavier in the persistent SHPT group than that in the successful PTX group (0.52 ± 0.31 vs. 0.38 ± 0.19, t = -2.733, p < 0.001). For persistent SHPT prediction, cutoff value of minimum weight of total 4 resected glands was 0.535 g, with sensitivity of 46.3% and specificity of 81.8% (AUC = 0.611; p = 0.029).
Conclusions
Major reason for persistent SHPT is the existence of supernumerary parathyroid in this study. The number of resected glands fewer than 4 might also increase the risk of persistent SHPT. There may be a missed supernumerary parathyroid gland left when 4 parathyroid glands were detected along with minimum parathyroid weight heavier than 0.535 g.
Influence of the contact area of the sub-antral space with sinus bone and the Schneiderian membrane on osteogenesis in lateral window sinus elevation surgery: A prospective experiment
Authors: She Xiao , Zhang Dongjiao , Xu Xin , Zhang Zhanwei , Ji Chonghao , Li Zechuan , Song Dawei 
Published: December 2022

Abstract
Background
Osteogenesis of lateral window sinus elevation surgery is the key to placement of the subsequent implant, excessive collapse of the sub-antral space may adversely affect long-term stability of implants. At present, few studies focus on the influence of the contact area of the sub-antral space on osteogenesis. This study evaluated whether the change in the contact area of the sub-antral space with maxillary sinus bone and the Schneiderian membrane can affect osteogenesis.
Methods
Cone beam computed tomography (CBCT) images were collected of patients requiring maxillary sinus floor elevation (residual bone height < 6 mm) for standard-length implant placement before surgery, after surgery, and at 6-month follow-up visits. The postoperative sub-antral space volume (V1) and surface area (S1), and the remaining volume after six months of healing (V2) were measured. Then, the contact area of sub-antral space with maxillary sinus bone (Sbc) and the Schneiderian membrane (Smc), the absorbed volume during healing (Va), and the percentage of remaining volume (V2%) and absorbed volume (Va%) were calculated. The correlation between anatomical parameters was analyzed using multiple linear regression.
Results
A total of 62 maxillary sinuses from 56 patients were augmented, of which 57 were considered for the final analysis (5 withdrew due to perforation). Multiple linear regression results demonstrated that Sbc was significantly positively correlated with Va (β coefficient = 0.141, p < 0.01) without correlation between Smc and Va (β coefficient=-0.046, p = 0.470). There was a positive correlation between Sbc and V2% (β coefficient = 2.269, p <0.05).
Conclusions
This study confirmed that the size of the Sbc in lateral window sinus elevation surgery affected osteogenesis after six months of healing. Clinicians should assess the sinus contour type preoperatively, then consider whether it is necessary to expand the range of the Schneiderian membrane elevation to avoid excessive collapse of the sub-antral space.
Trial registration
Chinese Clinical Trial Registry(ChiCTR), ChiCTR2200057924. Registered 22 March 2022 - Retrospectively registered.
A very promising antibiofilm activity against Candida albicans from an in vitro screening for antimicrobial, antibiofilm and antiproliferative activity of new synthesized 4-cinnamamido- and 2-phenoxyacedamido-1H-pyrazol-5-yl)benzamides.
Authors: Plescia Fabiana , Catania Valentina , D’Anneo Antonella , Raffa Demetrio , Lauricella Marianna , Schillaci Domenico 
Published: December 2022

Abstract

Several new synthesized 4-cinnamamido- and 2-phenoxyacedamido-1H-pyrazol-5-yl)benzamides were obtained by two multi step different synthetic routes in order to maximize their yield. The new derivatives were screened to determinate the antiproliferative, antimicrobial and antibiofilm activity. The biological results showed how, respect to the antiproliferative and antimicrobial activities, the compounds showed a low to missing activity. Different are the results obtained with respect to the antibiofilm activity, especially towards Candida albicans. Most of the synthesized compounds showed a good percentage inhibition of biofilm formation ranging from 60 to 73% with a Biofilm Inhibition Concentration 50% (BIC50) from 0.13 to 0.01 µM. Among the synthesized the ethyl 5-(4-(2-(4-chlorophenoxy)acetamido)benzamido)-1-methyl-1H-pyrazole-4-carboxylate (27c) resulted the most active with a BIC50 of 0.01 µM. According to the result obtained, such compound could be considered a lead subject of further studies to obtain novel and more effective antibiofilm agents against C. albicans infections.
When Macro Critical Climate Risk Comes True. Environmental Destruction and House Prices in Mar Menor, Spain
Authors: Perez-Quiros Gabriel , Rodriguez Matias Lamas , Lorenzo Maria de la Luz Garcia , Magro Manuel Medina 
Published: December 2022

Abstract
The frequency and severity of extreme events related to climate change have intensified worldwide in the last decades. It is documented that increasing extreme rainfall and flooding cause more nutrient runoff into waterbodies initiating numerous harmful algal bloom (HAB) events. We analyze the dramatic economic damage of one of these episodes in Mar Menor, the largest salt-water lagoon in Europe. We show that, when the public perceived the severity of environmental degradation, the return on housing investment was 43% lower in this area than in similar neighboring zones six years after the HAB (2015). This represents a loss in housing wealth of more than 4,000 million euros, around ten times the gains of changing from dry-farming to irrigated crops, which makes this ecosystem fragile. Hence, we quantify some of the economic consequences of ecological deterioration linked to Global Climate Change, a macro critical risk affecting the world economy.
Many-body chemical reactions in a quantum degenerate gas
Authors: Zhang Zhendong , Nagata Shu , Yao Kai-Xuan , Chin Cheng 
Published: December 2022

Abstract
Chemical reactions in the quantum degenerate regime are described by mixing of matterwave fields. Quantum coherence and bosonic enhancement are two unique features of many-body reactions involving bosonic reactants and products. Such collective reactions of chemicals, dubbed “super-chemistry”, is an elusive goal in quantum chemistry research. Here we report the observation of coherent and collective reactive coupling between Bose condensed atoms and molecules near a Feshbach resonance. Starting from an atomic condensate, the reaction begins with a rapid formation of molecules, followed by oscillations of their populations in the equilibration process. Faster oscillations are observed in samples with higher densities, indicating bosonic enhancement. We present a quantum field model which describes the dynamics well and identifies three body recombination as the dominant reaction process. Our findings exemplify the highly sought-after quantum many-body chemistry and offer a new paradigm for the control of quantum chemical reactions.
Prescribed Medications and Sarcopenia Development in Community-Dwelling Older Adults in Japan: A Kashiwa Cohort Study
Authors: Tanaka Tomoki , Akishita Masahiro , Kojima Taro , Son Bo-Kyung , Iijima Katsuya 
Published: December 2022

Abstract
Background
Clinical evidence demonstrating a longitudinal association between prescribed medications and sarcopenia onset is lacking. We investigated the association of polypharmacy (the use of five or more medications) and potentially inappropriate medications (PIMs) with sarcopenia risk in community-dwelling older adults.
Methods
In this longitudinal population-based cohort study, 2,044 older residents with no long-term care needs were randomly selected from a community in Kashiwa, Japan. Baseline data collection was conducted in 2012, with follow-ups in 2013, 2014, 2016, 2018, and 2021. Prescribed medications and PIMs (drugs listed in the Screening Tool for Older Person’s Appropriate Prescriptions for the Japanese or potentially muscle-wasting drugs) were identified through interviews. New-onset sarcopenia was identified according to the 2019 criteria of the Asian Working Group for Sarcopenia over a 9-year period and analyzed as an event using generalized estimating equations with repeated measures.
Results
Of the 1,549 participants without sarcopenia at baseline (mean age, 72.5 ± 5.5 years; 49.1% women; 6,256 total measurements over the 9-year follow-up; median and interquartile range, 6.0 [4.0–9.0] years), 230 experienced 260 events of new-onset sarcopenia during the follow-up. After adjusting for potential confounders, the prescription of ≥ 5 medications with PIM use was strongly associated with new-onset sarcopenia (adjusted odds ratio, 1.71; 95% confidence interval, 1.13–2.60; P = 0.011). No significant associations were observed for either PIM use or polypharmacy alone.
Conclusions
The combination of polypharmacy and PIM use was associated with an increased risk of new-onset sarcopenia over the 9-year follow-up period. Limiting polypharmacy and imposing the prescription of appropriate medications may facilitate sarcopenia prevention.
Rutin alleviates colon lesions and regulates gut microbiota in diabetic mice
Authors: Cai Cifeng , Cheng Wenwen , Shi Tiantian , Liao Yueling , Zhou Meiliang , Liao Zhiyong 
Published: December 2022

Abstract
Diabetes is a common metabolic disorder which has become a major health problem worldwide. In this study, we investigated the role of rutin in attenuating diabetes and preventing diabetes-related colon lesions in mice potentially through regulation of gut microbiota. The rutin from tartary buckwheat as analyzed by HPLC was administered intragastrically to diabetic mice, and then the biochemical parameters, overall community structure and composition of gut microbiota in diabetic mice were assayed. Results showed that rutin lowered serum glucose, improved serum total cholesterol, low density lipoprotein, high density lipoprotein, triglyceride concentrations, tumor necrosis factor-α, interleukin-6, and serum insulin in diabetic mice. Notably, rutin obviously alleviated colon lesions in diabetic mice. Moreover, rutin also significantly regulated gut microbiota dysbiosis and enriched the beneficial microbiota, such as Akkermansia. Rutin selectively increased the short-chain fatty acid producing bacteria, such as Alistipes and Roseburia, and decreased the abundance of diabetes-related gut microbiota, such as Escherichia and Mucispirillum. Our data suggested that rutin exerted anti-diabetic effect and alleviated colon lesions in diabetic mice possibly through regulating gut microbiota dysbiosis, which might be a potential mechanism through which rutin alleviates the diabetes-related symptoms.
Persistent SARS-CoV-2 PCR positivity despite treatment in immunodeficient patients
Authors: Chan Michele , Linn Me Me Nay , O’Hagan Thomas , Guerra-Assunção José Afonso , Lackenby Angie , Workman Sarita , Dacre Anna , Burns Siobhan O , Breuer Judith , Hart Jennifer , Tadros Susan , Lowe David M 
Published: December 2022

Abstract
Purpose:
COVID-19 infection in immunodeficient individuals can result in chronically poor health, persistent or relapsing SARS-CoV-2 PCR positivity, and long-term infectious potential. While clinical trials have demonstrated promising outcomes using anti-SARS-CoV-2 medicines in immunocompetent hosts, their ability to achieve sustained viral clearance in immunodeficient patients remains unknown. We therefore aimed to study longer term virological outcomes in patients treated at our centre.
Methods:
We followed up immunocompromised inpatients treated with casirivimab-imdevimab (Ronapreve) between September and December 2021, and immunocompromised patients who received sotrovimab, molnupiravir, nirmatrelvir/ritonavir (Paxlovid), or no treatment from December 2021 to March 2022. Nasopharyngeal swab and sputum samples were obtained either in hospital or in the community until sustained viral clearance, defined as 3 consecutive negative samples, was achieved. Positive samples were sequenced and analysed for mutations of interest.
Results:
We observed sustained viral clearance in 64 of 103 patients, none of whom died. Of the 39/103 patients where sustained clearance was not confirmed, 6 died (between 2 and 34 days from treatment). Notably, we observed 23 cases of sputum positivity despite negative NPS samples, as well as recurrence of SARS-CoV-2 positivity following a negative sample in 12 cases. Patients with viral clearance were then divided into those who cleared within 28 days and those with PCR positivity beyond 28 days. We noted lower B cell counts in the group with persistent PCR positivity (mean (SD) 0.08 (0.10) x109/L vs 0.22 (0.29) x109/L, p=0.01) as well as lower IgA (median (IQR) 0.00 (0.00-0.30) g/L vs 0.30 (0.00-0.90) g/L, p=0.03) and IgM (median (IQR) 0.10 (0.00-0.30) g/L vs 0.30 (0.10-0.75) g/L, p=0.007). No differences were seen in CD4+ or CD8+ T cell counts. Antiviral treatment did not impact risk of persistent PCR positivity.
Conclusion:
Persistent SARS-CoV-2 PCR positivity is common among immunodeficient individuals, especially those with antibody deficiencies, regardless of anti-viral treatment. Peripheral B cell count and serum IgA and IgM levels are predictors of viral persistence.
Effects of Various Irrigation Protocols Used in Regenerative Endodontic Procedures on the Migration, Proliferation, and Differentiation of Human Stem Cell from the Apical Papilla
Authors: Meeprasert Napas , Jantarat Jeeraphat , Wichai Wassana , Surarit Rudee , Hargreaves Kenneth M. 
Published: December 2022

Abstract
Objectives The aim of this study was to evaluate the effect of various irrigation protocols in regenerative endodontic procedures (REPS) on the attachment, proliferation, migration, and differentiation of stem cells from the apical papilla (SCAPs).
Materials and Methods Dentin specimens from 140 human third molars were irrigated with various protocols; group 1: normal sterile saline (NSS), group 2: EDTA, group 3: EDTA then 5 mL NSS, or group 4: EDTA then 20 mL NSS. The specimens were used in cell assays. For cell proliferation, SCAPs were seeded on dentin and the cell viability on days 1, 3, and 7 was determined using an MTT assay. At day 3, the attached cells’ morphology was observed using SEM and cell migration was investigated using a Transwell-migration assay. The ALP activity and odonto/osteogenic differentiation gene expression was evaluated at day 7, 14, and 21 using an ALP activity assay and RT-qPCR.
Results On day 3 and 7, group 4 demonstrated more viable cells than group 1 (p < 0.01). The amount of migrated cells in group 2, 3, and 4 was greater compared with group 1 (p < 0.05). Moreover, SCAP differentiation was similar between groups.
Conclusions Irrigating dentin with EDTA alone or with EDTA then NSS promoted SCAP migration. However, a final irrigation with 20 mL NSS after EDTA promoted SCAP proliferation without affecting their differentiation.
Clinical relevance When using a blood clot as a scaffold, a final flushing with 20 mL NSS after EDTA could be beneficial for clinical REP protocols.
BIM-based Digital Platform and Risk Management System for Mountain Tunnel Construction
Authors: Liu Naifei , Guo Desai , Song Zhanping , Zhong Shiming , Hu Ruoqi 
Published: December 2022

Abstract
There are often varieties of complex and changeable potential risks during the construction of mountain tunnels, of which the management and control are critical to ensure the construction safety of mountain tunnels. With the rapid development of engineering information technologies such as Building Information Model (BIM), internet, big data and cloud computing, dynamic management of mountain tunnel construction will become an inexorable trend. Based on digital and integrated mountain tunnel management, this paper combines monitoring measurement with advanced geological prediction based on BIM technology, which is a new digital means, to realize the informatization and visualization of risk management in mountain tunnel construction. This paper proposes a BIM-based digital platform architecture for mountain tunnel construction, which is categorized into basic layer, model layer, data layer, application layer and user layer. Through the integration of the five layers, this paper can realize the information about risk management during the construction of mountain tunnels. Meanwhile, based on the digital platform, a set of dynamic risk management systems including risk monitoring, risk identification and risk assessment is established. The digital platform and dynamic risk management system proposed in this paper have certain advantages in the construction of mountain tunnels and provide a new way for the management of safety risk in the construction of mountain tunnels, which has very important significance in the construction safety and risk control of mountain tunnel.