bluuebunny/crossref_metadata_2025_split huggingface dataset:
Special military operation as a tool of increasing the anti-corruption potential
Authors: Inshakov S. M. , Kazakova V. A. 
Published: December 2022

Objective: to analyze the dynamics of Russia’s anti-corruption potential in connection with the socio-political conditions of the modern Russian society development.Methods: a dialectical approach to the cognition of social phenomena, which allows analyzing the interrelation of such phenomena as politics, economics, power, corruption, as well as using comparative-historical, systemic, institutional, abstract-logical methods to predict ways to increase the anti-corruption potential of society and its anti-corruption stability.Results: the development of the anti-corruption potential of the modern Russian state is predicted, based on the formation of civil society under the influence of socio-economic and socio-political processes taking place in Russia against the background of the special military operation. The regularities in the actions of the ruling elite representatives in various difficult periods of the state development are stated, including during the special military operation of the Russian Armed Forces in the territory of Ukraine.Scientific novelty: the work presents a comparative study of the dependence between the spread of corruption in society, on the one hand, and the socio-political conditions and the characteristics of the ruling elite, on the other, including under the conditions of modern society in its extreme state during the special military operation; the impact of these conditions on the anti-corruption stability of society is also studied.Practical significance: consists in the possibility to formulate forecasting assessments regarding the ability to increase the anti-corruption potential of the society (anti-corruption sustainability of the society) and ways to achieve the goal of fighting corruption.
WITHDRAWN: Lignin metabolism involved in zinc-alleviating effects on iron-induced phytotoxicity in wheat roots
Authors: Li Yaping , Zhang Ya , Zhang Aimei , Wang Zhaofeng , Li Qiong , Shi Shuqian , Yang Yingli 
Published: December 2022

Abstract
In order to reveal the mechanisms of Fe-inhibited plant root growth and Zn-alleviating effects on iron (Fe) toxicity, wheat cultivars Xihan 4 seedlings were used to investigate the relationship between root growth and synthetic metabolism of lignin in response to 300 µM Fe stress alone or in combination with 50 or 250 µM zinc (Zn). Fe-alone-exposed roots exhibited significant increase of cell wall lignin content and the stimulation of phenylalanine ammonia-lyase (PAL), 4-coumarate:CoA ligase (4CL), cinnamyl alcohol dehydrogenase (CAD), laccase (LAC), cell wall bound guaiacol peroxidase activity (CW-bound GPX) and conifers alcohol peroxidase (CAPX) activities as well as the up-regulation of TaPAL, Ta4CL, TaCAD and TaLAC expression. In comparison with Fe stress alone, the presence of Zn effectively alleviated the changes of these parameters in Fe-treated roots. And also, the results of lignin staining in the root tissue were consistent with those of lignin detection in wheat seedlings under different treatments. Further study showed the increase of apoplastic hydrogen peroxide (H2O2) content in conjunction with the stimulation of CW-bound nicotinamide adenine dinucleotide (NADH) oxidase, plasma membrane (PM) nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and apoplastic superoxide dismutase (SOD) in Fe-alone-stressed roots compared with untreated ones, but Fe + Zn treatment partially reversed the changes of these parameters in comparison with Fe exposure alone. Furthermore, the application of exogenous H2O2 not only enhanced the amount of cell wall lignin in Zn + Fe-treated roots but also significantly blocked Zn-alleviating effect on Fe-induced inhibition of root growth. In conclusion, the inhibition of root growth was associated with the increased accumulation of cell wall lignin in response to Fe exposure alone, which was due to the stimulation of lignin metabolizing enzymes and the up-regulation of related enzyme gene expression and the increase of apoplastic H2O2 generation in wheat roots under Fe exposure alone. It was also suggested that Zn-alleviating effect on Fe-induced inhibition of root growth might be related to the reduction of lignin content of root cell wall resulting from the decrease of apoplastic H2O2 content when wheat seedlings were exposed to Fe + Zn treatment.
Bio-Inspired Motivated Developmental Learning for Dynamic Collision-Avoidance of Mobile Robots
Authors: Wang Dongshu , Xiong Ziyi , Liu Lei , Weng Kangrong 
Published: December 2022

Abstract
In the environment cognition, except the xpected obstacles, the mobile robots might encounter unexpected obstacles. How to effectively deal with the unexpected obstacles is a challenge for the mobile robots. Unfortunately, researches about the unexpected obstacles in the environment cognition of the mobile robots are relatively scarce. Even though there are some works attempts to address it, these methods generally lack the ability of autonomous learning, which makes it difficult for the mobile robots to respond to the changed environments quickly and flexibly. Simulating the neuromodulatory mechanism of acetylcholine and norepinephrine in meditating the attention network, collision risk, which not only considers the influence of the obstacle distance on the movement of the mobile robots just like in the traditional methods, but also that of the obstacle speed, is designed to switch the attention network of the mobile robot between the dorsal attention network, which directs attention to anticipated stimuli (expected obstacles), and ventral attention network, which directs attention to novel stimuli (unexpected obstacles). Mimicking the neuromodulatory of acetylcholine and norepinephrine on dopamine and 5-HT, a novel learning rate is designed to accelerate the learning of the neurons in hidden layer of the motivatd developmental network, making the robots response to the changed environment quickly and flexibly. Moreover, weight updating rules are modified to improve the accuracy of the action selection of the mobile robots. Results in four simulation scenarios and the physical experiment demonstrate the feasibility of the proposed methodology in dealing with the unexpected obstacles in the environment cognition of the mobile robots.
Neutrophil-targeted Mn3O4 nanozyme treats myocardial ischemia reperfusion injury by scavenging reactive oxygen species
Authors: Wang Fuhang , Han Dongjian , Qiao Zhentao , Zhuang Yuansong , Zhang Yi , Jiang Qingjiao , Liu Miaomiao , An Quanxu , Shen Deliang 
Published: December 2022

Abstract
Background: The core pathophysiological process of myocardial ischemia reperfusion injury (MIRI) is the excessive reactive oxygen species (ROS) production (including •O2-, H2O2, •OH) in the injured areas. Manganese tetroxide (Mn3O4) nanozymes are capable of scavenging multiple ROS, but whether they are applicable in MIRI is unclear. Rat IgG-modified liposomes can be specifically phagocytosed by activated neutrophils. Activated neutrophils can penetrate the vascular barrier and infiltrate into the inflamed myocardial tissue induced by MIRI. We synthesized IgG-Lip-Mn3O4 (rat IgG-modified liposomes encapsulated with Mn3O4 nanozyme). It is unclear whether they can be phagocytosed by activated neutrophils and then infiltrate into deep myocardial tissues to remove excess ROS.
Methods: Fluorescent probe technique was used to test ROS scavenging ability of IgG-Lip-Mn3O4. Apoptosis and cell death were detected with regular staining kits. Flow cytometry and in vivo imaging system were used to evaluate the targeting ability of IgG-Lip-Mn3O4 on myocardial tissue. Serum inflammatory factors were measured with ELISA kits. Echocardiography was used to detected cardiac function. Pathological staining was used to detected scar size, cardiac fibrosis, and cardiac remodeling. Immunofluorescence was used to detect vascular regeneration and macrophage polarization.
Results: Mn3O4 nanozyme can scavenge various ROS such as •O2-, •OH and exert therapeutic effects in MIRI. IgG-Lip-Mn3O4, specifically phagocytosed by activated neutrophils, can be carried to the deep injured areas by utilizing the chemotactic effect of activated neutrophils towards inflammation areas. IgG-Lip-Mn3O4 could remove excess ROS from the injured areas, reduce the release of inflammatory factors and increase the content of M2-phenotype macrophages. It also protected cardiomyocytes against apoptosis and decreased the infarction size. IgG-Lip-Mn3O4 not only decreased scar tissue accumulation and ventricular remodeling, but also promoted angiogenesis and restored cardiac function. In addition, IgG-Lip-Mn3O4 was biocompatible and did not cause organ toxicity.
Conclusions: IgG-Lip-Mn3O4 can specifically reach the injured areas and remove a variety of ROS. By reducing inflammatory responses and apoptosis, IgG-Lip-Mn3O4 provided precise and effective treatment for MIRI.
Increased cytotoxicity of Irinotecan or 5FU by expression of p16 INK4a in A549 lung carcinoma cell
Authors: Eizadkhah Ali , Afsari Nadia Samareh , Ostad Seyed Nasser , Nourian Yazdan Hasani , Ghahremani Mohammad Hossein 
Published: December 2022

Abstract
One of the main pathways for cell cycle control is the block of cyclin D1/CDK4 by p16INK4a. In many malignancies, including lung cancer, the p16INK4a gene has been, mutated, methylated or deleted, resulting in the tumor progression. We have previously show that the C-terminal truncated form of p16 can inhibits cell growth, restrain cell cycle at G0/G1and induce cell death similar to full length. In this study we have tested whether, the truncated p16 can have additive effect on irinotecan or 5FU induced cytotoxicity in A549 lung adenocarcinoma cells. The truncated as well as full length p16 was transfected into A549 cell line and the expression level was evaluated. The cell viability and cell cycle of the cells treated with drugs was measured with MTT test and flow cytometry. Both full length and truncated p16 induced cytotoxicity in these cells. The expression of p16 decreased cell viability of A549 treated with irinotecan or 5FU were 40.99 ± 2.28 and 41.95 ± 3.28 in IC25, respectively. The viability of cells expressing p16 and treated with IC50 and IC25 of irinotecan or 5FU was significantly reduced. The expression of truncated p16 increased cytotoxicity of 5FU by 80% in IC25 treated cells. Considering the drug treated dose, the expression of truncated p16, in lower drug dose has induced more cytotoxicity. Similarly, the cell cycle arrest and subG1 was increased in cell expressing truncated p16 and treated with drug. Therefore, the expression of truncated p16 has augmented the cytotoxicity of 5FU in A549 cells and the expression of p16 or molecule similar to p16 have the potential to be used as combination therapy in treatment of lung cancer.
Analysis of relationship between P wave dispersion and diagnosis of pulmonary arterial hypertension and risk stratification
Authors: Luo Jun , Sun Jingjie , Xu Li , Chen Jingyuan , Chen Yusi , Chen Wenjie , Qiu Haihua , Luo Xiaoqin , Chen Sisi , Li Jiang 
Published: December 2022

Abstract
Objectives: The aim of this study was to measure the P-wave dispersion(PWD) in the ECG of patients with pulmonary arterial hypertension(PAH).
Methods: A total of 103 PAH patients were collected, including 55 patients related with CHD and 44 patients with IPAH. In addition, 30 CHD patients without PAH (nPAH-CHD group) and 30 healthy controls (HCG group) were collected as control. Patients in the PAH group were categorized into the low-risk group (30 cases), moderate-risk group (53 cases) and high-risk group (20 cases), followed by comparison of PWD difference between groups. The ROC curve was used to evaluate the diagnostic efficacy of PWD on PAH-CHD and IPAH.
Results: The levels of PWD and Pmax in PAH-CHD and IPAH group were significantly higher than those in nPAH-CHD and HCG group (P<0.05). PWD level was positively correlated with RVD, RAS, mPAP, PVR (r=0.407, 0.470, 0.477, 0.423, P<0.001), and was negatively correlated with TAPSE level (r =-0.551, P<0.001). After risk quantification in 103 PAH patients, we found that PWD was significantly different among the low-risk, moderate-risk and high-risk groups (43.89 ± 9.91 vs. 51.29 ± 6.61, 62.15 ± 10.44, P<0.001). CHD-PAH and IPAH were identified by PWD with a cut off value of 41.5ms (P< 0.001), and a cut off value of 41.45ms (P< 0.001), respectively.
Conclusion: PWD might be an effective ECG indicator for PAH, which might be used as a relatively economical and easily accessible indicator for PAH patients to assist in early diagnosis, disease severity assessment and prognosis evaluation.
The lncRNA Sros1 is involved in the development of cardiac fibrosis by regulating the TGF-β/SMAD2/3 signaling cascade
Authors: Xu Tianyu , Xu Henan , Ma Zhuang , Huang Yuli , Xu Jia , Chai Yangyang , Zhang Hao , Wang Xiao , Xu Dingli , Zhang Yuhui , Zhang Jian 
Published: December 2022

Abstract
Aim: Myocardial fibrosis is one of the common pathophysiological mechanisms of heart failure (HF) caused by various etiologies. Interferon (IFN)-γ plays a key role in the body's defense against pathogen infection and antitumor and adaptive immune responses. However, long-term treatment with IFN-γ is closely related to an increased risk of cardiomyocyte necrosis and myocardial fibrosis. A recent study found that the long noncoding RNA Sros1（Sros1） can enhance IFN-γ when inducibly degraded or genetically lost. This study aimed to explore whether Sros1 plays a role in the incidence and development of cardiac fibrosis and HF.
Methods: Sirius red staining, Masson staining and the expression of proteins related to myocardial fibrosis in Sros1 gene-deleted (Sros1-/-) mice and wild-type (WT) mice were compared. Changes in Sros1 in the heart and the expression of molecules related to myocardial fibrosis in both WT mice and Sros1-/- mice with chronic isoproterenol infusion (ISO) were observed. The expression levels of proteins related to myocardial fibrosis and the TGF-β/SMAD signaling pathway in cardiac fibroblasts overexpressing the Sros1 by lentivirus were detected.
Results: Both Sirius red and Masson staining, as well as the expression of TGF-β/SMAD signaling pathway genes, showed increased cardiac fibrosis in Sros1-/- mice. The Sros1 gene significantly decreased in the hearts of the WT mice with ISO infusion 28 days after. Compared with that of the WT ISO model, the myocardial fibrosis of the Sros1-/- ISO model was significantly increased, as well as genes of the TGF-β/SMAD signaling pathway were elevated. Overexpression of the Sros1 by lentivirus in cardiac fibroblasts decreased the ISO-induced and TGF-β-induced expression of proteins related to myocardial fibrosis and the TGF-β/SMAD signaling pathway.
Conclusion: Cardiac fibrosis was increased in Sros1-/- mice. The elevation of cardiac fibrosis in the Sros1-/- ISO group was more obvious and may be mediated through the TGF-β/SMAD signaling pathway.
A novel ferroptosis-related lncRNA pair prognostic signature and nomogram for predicting the survival of patients with lung adenocarcinoma
Authors: Wang Qianchao , Lin Ting , Wu Xiaotang , Liu Jianming 
Published: December 2022

Abstract
Purpose
Ferroptosis is a novel programmed cell death process and is considered a feasible cancer treatment strategy. Long non-coding RNAs (lncRNAs) are key mediators of ferroptosis and iron metabolism in cancer. However, the prognosis of ferroptosis-related lncRNAs (FRLs) in lung adenocarcinoma (LUAD) remains unclear.
Method
RNA-seq data and clinical information of patients with LUAD were retrieved from GSE81089. Differentially expressed lncRNAs (DELs) and ferroptosis-related genes (DE-FRGs) were identified in LUAD and normaltissues, followed by the construction of a DEL and DE-FRG network to obtain FRLs. Univariate Cox regression and LASSO regression analyses were performed to select lncRNA pairs to construct a prognostic model. Receiver operating characteristic (ROC) curve analysis was used to assess the performance of the model. Independent prognostic factors were screened to establish a nomogram model. Based on the optimal cut-off value, patients were classified into low-risk (LR) and high-risk (HR) groups. Differences in pathways, immune cell infiltration, immune checkpoint genes, and drug susceptibility between the two risk groups were evaluated.
Results
Eighteen FRL pairs were identified to construct a prognostic model, and patients were divided into LR and HR groups based on the median risk score of this model. Patients in the HR group had worse prognosis than those in the LR group. The area under the curve of the ROC curve verified that this model had good predictive ability. The pTNM stage and risk scores were independent prognostic factors that were used to develop the nomogram, which accurately predicted the survival of patients with LUAD. Functional analysis showed that starch and sucrose metabolism pathways were enriched in the LR group. Compared with the LR group, the HR group was associated with higher immune infiltration status, increased expression levels of immune checkpoints (BTLA, CD274, and HAVCR2), and higher drug sensitivity.
Conclusion
In conclusion, our prognostic model containing 18 FRL pairs showed excellent predictive ability for LUAD prognosis. This may guide personalized immunotherapy strategies for patients with LUAD.
Perfusability and immunogenicity of implantable pre-vascularized tissues recapitulating native capillary network
Authors: Zhao Feng , Sharma Dhavan , Sharma Archita , Hu Linghao , Chen Te-An , Voon Sarah , Bayless Kayla , Goldman Jeremy , Walsh Alex 
Published: December 2022

Abstract
Vascularization is a key pre-requisite to engineered anatomical scale three dimensional (3-D) constructs to ensure their nutrient and oxygen supply upon implantation. Presently, engineered pre-vascularized 3-D tissues are limited to only micro-scale hydrogels, which meet neither the anatomical scale needs nor the complexity of natural extracellular matrix (ECM) environments. Anatomical scale perfusable constructs are critically needed for translational applications. To overcome this challenge, we previously developed prevascularized ECM sheets with long and oriented dense microvascular networks. The present study further evaluated the patency, perfusability and innate immune response toward these pre-vascularized constructs. Macrophage-co-cultured pre-vascularized constructs were evaluated in vitro to confirm micro-vessel patency and perturbations in macrophage metabolism. Subcutaneously implanted pre-vascularized constructs remained viable and formed a functional anastomosis with host vasculature within 3 days of implantation. This completely biological pre-vascularized construct has a great potential to serve as a building block to engineer perfusable anatomical scale tissues.
A Framework for Imbalanced Modelling in Disaster Management: A Case Study Involving Global Landslide Susceptibility
Authors: Liu Junfei , Liu Kai , Wang Ming 
Published: December 2022

Abstract
This paper proposes a modelling framework for imbalanced problems in the field of disaster management. Global landslide susceptibility was used as a case study. After investigating metrics for imbalanced classifiers, six metrics were selected: AUC, F1, Precision, Recall, G-mean and Kappa. A comparison was made between methods in the imbalanced learning domain and commonly used strategies in the disaster domain. Ten supervised learning classifiers were built, and the extra Tree classifier outperformed other classifiers according to the post hoc test. The ET classifier built by the SMOTE & ENN hybrid sampling dataset outperformed the other classifiers, and the AUC and F1 were 0.9533 and 0.1049, respectively, on the five validation sets. Such a result indicates that the model has strong robustness and outstanding performance. It was found that the imbalanced learning framework can significantly improve the performance of disaster classifiers even at a global scale.
A spatially guided machine learning method to classify and quantify glomerular patterns of injury in histology images
Authors: Besusparis Justinas , Morkunas Mindaugas , Laurinavicius Arvydas 
Published: December 2022

Abstract
INTRODUCTION
Pathology diagnosis of glomerular diseases is primarily based on visual assessment of histologic patterns. Semi-quantitative scoring of active and chronic lesions is often required to assess individual characteristics of the disease. Reproducibility of the visual scoring systems remains debatable while digital and machine learning technologies open opportunities to detect, classify and quantify glomerular lesions, also considering their inter- and intraglomerular heterogeneity.
MATERIALS AND METHODS
We performed a cross-validated comparison of three modifications of a convolutional neural network (CNN)-based approach for recognition and intraglomerular quantification of nine main glomerular patterns of injury. Reference values provided by two nephropathologists were used for validation. For each glomerular image, visual attention heatmaps were generated with a probability of class attribution for further intraglomerular quantification. Quality of classifier-produced heatmaps was evaluated by an intersection over union metrics (IoU) between predicted and ground truth localization heatmaps.
RESULTS
A proposed spatially guided modification of CNN classifier achieved the highest glomerular pattern classification accuracies with AUC values up to 0.981. With regards to heatmap overlap area and intraglomerular pattern quantification, spatially guided classifier achieved significantly higher generalized mean IoU value, compared with single-multiclass and multiple-binary classifiers.
CONCLUSIONS
We propose a spatially guided CNN classifier which in our experiments reveals the potential to achieve high accuracy for intraglomerular pattern localization.
Room Temperature Optically and Magnetically Active Edges in Phosphorene Nanoribbons
Authors: Pandya Raj , Ashoka Arjun , Clancy Adam , Panjwani Naitik , Popiel Nicholas , Eaton Alexander , Parton Thomas , Picco Loren , Feldmann Sascha , Shutt Rebecca , Carey Remington , Aw Eva , Macdonald Thomas , Severijnen Marion , Kleuskens Sandra , de Aguiar Hilton Barbosa , Friend Richard , Behrends Jan , Christianen Peter , Howard Christopher , Rao Akshay 
Published: December 2022

Abstract
Nanoribbons – nanometer wide strips of a two-dimensional material – are a unique system in condensed matter. They combine the exotic electronic structures of low-dimensional materials with an enhanced number of exposed edges, where phenomena including ultralong spin coherence times1–4, quantum confinement5 and topologically protected states6–8 can emerge. An exciting prospect for this new material concept is the potential for both a tunable semiconducting electronic structure and magnetism along the nanoribbon edge. This combination of magnetism and semiconducting properties is the first step in unlocking spin-based electronics such as non-volatile transistors, a route to low-energy computing9, and has thus far typically only been observed in doped semiconductor systems and/or at low temperatures10–15. Here, we report the magnetic and semiconducting properties of phosphorene nanoribbons (PNRs). Static (SQUID) and dynamic (EPR) magnetization probes demonstrate that at room temperature, films of PNRs exhibit macroscopic magnetic properties, arising from their edge, with internal fields of ~ 240 to 850 mT. In solution, a giant magnetic anisotropy enables the alignment of PNRs at modest sub-1T fields. By leveraging this alignment effect, we discover that upon photoexcitation, energy is rapidly funneled to a dark-exciton state that is localized to the magnetic edge and coupled to a symmetry-forbidden edge phonon mode. Our results establish PNRs as a fascinating system for studying the interplay of magnetism and semiconducting ground states at room temperature and provide a stepping-stone towards using low-dimensional nanomaterials in quantum electronics.