bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurotrophin Pathway Receptors NGFR and TrkA Control Perineural Invasion, Metastasis, and Pain in Oral Cancer
Authors: Doan Coleen , Aouizerat Bradley E. , Ye Yi , Dang Dongmin , Asam Kesava , Bhattacharya Aditi , Howard Timothy , Patel Yogin K. , Viet Dan T. , Figueroa Johnny D. , Zhong Jiang F. , Thomas Carissa M. , Morlandt Anthony B. , Yu Gary , Callahan Nicholas F. , Allen Clint T. , Grandhi Anupama , Herford Alan S. , Walker Paul C. , Nguyen Khanh , Kidd Stephanie C. , Lee Steve C. , Inman Jared C. , Slater Jason M. , Viet Chi T. 
Published: August 2022

AbstractOral squamous cell carcinoma (OSCC) patients suffer from poor survival due to metastasis or locoregional recurrence, processes that are both facilitated by perineural invasion (PNI). OSCC has higher rates of PNI than other cancer subtypes, with PNI present in 80% of tumors. Despite the impact of PNI on oral cancer prognosis and pain, little is known about the genes that drive PNI, which in turn drive pain, invasion, and metastasis. In this study, clinical data, preclinical, and in vitro models are leveraged to elucidate the role of neurotrophins in OSCC metastasis, PNI, and pain. The expression data in OSCC patients with metastasis, PNI, or pain demonstrate dysregulation of neurotrophin genes. TrkA and nerve growth factor receptor (NGFR) are focused, two receptors that are activated by NGF, a neurotrophin expressed at high levels in OSCC. It is demonstrated that targeted knockdown of these two receptors inhibits proliferation and invasion in an in vitro and preclinical model of OSCC, and metastasis, PNI, and pain. It is further determined that TrkA knockdown alone inhibits thermal hyperalgesia, whereas NGFR knockdown alone inhibits mechanical allodynia. Collectively the results highlight the ability of OSCC to co‐opt different components of the neurotrophin pathway in metastasis, PNI, and pain.
A Single‐Step‐Grown Semiconducting vdW Heterostructure of Tungsten Oxide–Sulfide for High‐Performance Photodetection
Authors: Chen Guanyu , Hu Xinyi , Gu Mingwei , Wu Hao , Chen Keyu , Yu Hao , Ren Baiyu , Li Zhong , Luan Yange , Tang Tao , Cheng Yinfen , Huang Haibo , Chen Liguo , Zhang Bao Yue , Ou Jian Zhen 
Published: August 2022

AbstractUltrathin semiconducting van der Waals (vdW) heterostructures based on transition metal dichalcogenides (TMDs) play a critical role in developing next‐generation electronic and optoelectronic devices. The replacement of one component of the heterostructure by transition metal oxides (TMOs) certainly brings in numerous benefits including long‐term stability and novel functionalities. However, the single‐step chemical‐vapor deposition growth of TMOs/TMDs vdW heterostructures, as a highly desired approach for large‐scale fabrication and practical implementation, is challenging due to contradictory growth atmospheres of TMOs and TMDs. Here, the single‐step growth of an ultrathin WO3–x/WS2 vdW heterostructure based on the quantity‐driven discrepant interaction between S and the precursor, in which S induces sulfidation to produce WS2 in the S‐rich phase and is changed to the reduction role to obtain sub‐stoichiometric WO3–x in the S‐deficient phase is realized. Both WO3–x and WS2 exhibit semiconducting properties with a favorable type‐II band alignment. A wide response across the entire visible spectrum with a large photo‐responsivity of 4375 A W−1, a detectivity of 5.47 × 1011 Jones, and sub‐ms switching kinetics at 405 nm is achieved without gating bias, which is significantly improved over other reported ultrathin vdW heterostructures. This study demonstrates the possibility of single‐step‐growing TMOs/TMDs vdW heterostructures and their strong potential in high‐performance optoelectronic devices.
Stabilizing Interfacial Reactions for Stable Cycling of High‐Voltage Sodium Batteries
Authors: Jin Yan , Xu Yaobin , Xiao Biwei , Engelhard Mark H. , Yi Ran , Vo Thanh D. , Matthews Bethany E. , Li Xiaolin , Wang Chongmin , Le Phung M. L. , Zhang Ji‐Guang 
Published: August 2022

AbstractDeveloping advanced electrolytes is critical for stabilizing electrode/electrolyte interfacial reactions and thus extending cycling stability of sodium (Na) batteries, especially when a high‐voltage cathode (such as NaNi0.68Mn0.22Co0.10O2 (NaNMC)) is used to achieve high energy density in batteries. Here, an advanced electrolyte based on sodium bis(fluorosulfonyl)imide (NaFSI)–triethyl phosphate, which is highly stable against a high‐voltage cathode, enabling long‐term cycling of sodium batteries, is reported. Na||NaNMC cells with this electrolyte demonstrate 89% capacity retention after 500 cycles with a cutoff voltage of 4.2 V versus Na/Na+. A full cell of hard carbon||NaNMC also exhibits good capacity retention of 83.5% after 200 cycles. Postmortem analyses on the cycled electrodes reveal that stabilization of the high‐voltage cathode can be attributed to the formation of a stable electrode/electrolyte interphase layer. The interphase is generated mainly by salt decomposition, which suppresses transition metal dissolution and surface reconstruction on the cathode. The optimized electrolyte can minimize solid electrolyte interphase dissolution to avoid capacity loss. This study offers a feasible pathway to achieve extended cycling of high‐voltage sodium batteries and guide further improvements in cycling performance of batteries by manipulating the chemistry of the electrolytes and interphase properties.
Stabilization, Characterization, and Electrochemical Applications of High‐Entropy Oxides: Critical Assessment of Crystal Phase–Properties Relationship
Authors: Tomboc Gracita M. , Zhang Xiandi , Choi Songa , Kim Daekyu , Lee Lawrence Yoon Suk , Lee Kwangyeol 
Published: August 2022

AbstractHigh‐entropy oxides (HEOs), a class of newly emerging energy conversion and storage technology materials, have gained significant interest due to their unique structure, complex stoichiometry, and corresponding synergetic effect. Despite the increasing number of reported studies related to HEOs in recent years, details of their structural properties and electrochemical activities are still lacking. Herein, the exciting developments of HEOs regarding their design, synthesis, characterization, theoretical calculations, and electrochemical performances are outlined. The fundamentals of HEOs, including their strict definition, main features, and four‐core aspect effects are presented. The different synthetic methods of HEOs are categorized to highlight the significance of parameter optimization to ensure the single‐phase stability of HEOs. The advances in characterization techniques on the local lattice and atomic distribution and the basic principles of combinatorial screening methods based on computational techniques are also elaborated. Recent HEO‐based electrode/electrocatalysts toward Li‐ion batteries and oxygen catalysis are reviewed to assess the potential applications of HEOs. This review draws attention to the critical challenges of HEOs that are worth more extensive explorations in the future.
Drum Tower‐Inspired Kirigami Structures for Rapid Fabrication of Multifunctional Shape‐Memory Smart Devices with Complex and Rigid 3D Geometry in a Two‐Stage Photopolymer
Authors: Li Xingjian , Gai Yijie , Sun Maocheng , Li Yinwen , Xu Shoufang 
Published: August 2022

AbstractMechanically robust shape‐morphing materials that can transform from miniaturization into complex structures are highly desirable for real‐world device applications. However, fabricating mechanically robust yet geometrically complex 3D shape‐morphing structures with excellent functionality and high load‐bearing capacity remains a challenge. Inspired by drum tower buildings, a simple, rapid, and universal method is presented for fabricating multifunctional shape‐memory smart devices with complex and rigid 3D kirigami geometry in the two‐stage epoxy‐amine‐acrylate photopolymer systems. In the first‐stage reaction, transparent polymer films with a Tg of 29–49 °C are obtained by the epoxy‐amine chemistry. The shape‐memory programming process allows the first‐stage film with a drum tower‐inspired 2D kirigami pattern to be manipulated into an unsupported 3D structure. In the second‐stage reaction, UV‐induced free‐radical polymerization of methacrylate groups in the first‐stage network is employed to rapidly lock the programmed 3D kirigami structure with a Tg of 66–138 °C. The drum tower‐inspired 3D kirigami structure withstands 1000 times its own weight. The shape memory fluorescent 3D device and shape memory electronic 3D device are engineered by combining the two‐stage photopolymer system and a 3D kirigami structure. This work represents a versatile method to create multifunctional shape‐memory devices with rigid 3D geometry for potential applications.
Coding of Non‐Linear White‐Light Luminescence from Gold‐Silicon Structures for Physically Unclonable Security Labels
Authors: Ponkratova Ekaterina , Ageev Eduard , Trifonov Peter , Kustov Pavel , Sandomirskii Martin , Zhukov Mikhail , Larin Artem , Mukhin Ivan , Belmonte Thierry , Nominé Alexandre , Bruyère Stéphanie , Zuev Dmitry 
Published: August 2022

AbstractLuminescent security labels are effective platforms for protection of consumer goods from counterfeiting. However, the lifetimes of such security approaches are limited due to narrow‐band photoluminescent features of the label elements, which can be used for the protection technology disclosure. In this paper, a novel concept for the application of non‐linear white‐light luminescence from hybrid metal–semiconductor structures fabricated by direct femtosecond laser writing for the creation of physically unclonable security labels is proposed. A close connection is demonstrated between the internal composition of hybrid structures, which is controlled at the fabrication stage, and their non‐linear optical signals. It is shown that the application of decorrelation procedure based on discrete cosine transform and polar codes for label coding can overcome the problem of the white‐light photoluminescent spectra correlation. The proposed fabrication approach and coding strategy allows reaching a high degree of device uniqueness (up to 99%), bit uniformity (close to 0.5), and encoding capacity up to 1.25 × 10437 in a single label element. The results demonstrate that the barriers for the application of white‐light luminescent nano‐objects for the creation of physically unclonable labels are removed.
Suppressing the Loss of Polymer‐Based Dielectrics for High Power Energy Storage
Authors: Pei Jia‐Yao , Yin Li‐Juan , Zhong Shao‐Long , Dang Zhi‐Min 
Published: August 2022

AbstractPolymer‐based dielectrics have received intensive interest from academic community in the field of high‐power energy storage owing to their superior flexibility and fast charge–discharge ability. Recently, how to suppress the loss of polymer‐based dielectrics has been increasingly recognized as a critical point to attain a high charge–discharge efficiency in the film capacitors. Some achievements are made in analyzing the source of loss and suppressing loss via Edison's trial and error method. In this review, the significance of suppressing loss in polymer‐based dielectrics is firstly emphasized. Then, different sources of loss are discussed carefully and an in‐depth analysis of the related measurements is presented. Next, recent research results in suppressing loss are summarized and discussed in detail according to different strategies. Finally, the challenges and opportunities in the loss suppression research for the rational design of high‐efficiency polymer‐based dielectrics are proposed.
Experimental Realization of a Superdispersion‐Enabled Ultrabroadband Terahertz Cloak
Authors: Cai Tong , Zheng Bin , Lou Jing , Shen Lian , Yang Yihao , Tang Shiwei , Li Erping , Qian Chao , Chen Hongsheng 
Published: August 2022

AbstractInvisibility has been a topic of long‐standing interest owing to the advent of metamaterials and transformation optics, but still faces open challenges after its tremendous development in recent decades. One of the big challenges is the narrow bandwidth, as the realization of an invisibility cloak is usually based on a metamaterial—an artificial composite material composed of subwavelength resonator structures that are always associated with dispersion. Different from previous works that have tried to eliminate the material dispersion to enhance the bandwidth of an invisibility cloak, here, it is found that by judiciously harnessing the material dispersion, the bandwidth of the cloak can still be significantly increased. Interestingly, the material dispersion does not violate the law of causality. As a proof of concept, an ultrabroadband terahertz (THz) carpet cloak is experimentally demonstrated through an array of superdispersive microparticles, rendering the target object invisible to detection by both time‐ and frequency‐domain wideband systems. The work presents a feasible invisibility strategy that is closer to practical applications and may pave a brand‐new way for the development of dispersion‐dominated ultrabroadband metadevices.
Strategy to Construct High Thermal‐Stability Narrow‐Band Green‐Emitting Si‐CDs@MAs Phosphor for Wide‐Color‐Gamut Backlight Displays
Authors: Chen Jianying , Zou Xikun , Li Wei , Zhang Haoran , Zhang Xuejie , Molokeev Maxim S. , Liu Yingliang , Lei Bingfu 
Published: August 2022

AbstractDeveloping innovative narrow‐band green‐emitting phosphors featuring low thermal quenching and eco‐friendliness for white light‐emitting diode (WLED) backlights is a pivotal challenge. Benefitting from narrowband and low toxicity of green‐emitting silanized carbon dots (Si‐CDs), an efficient confinement and protection strategy through embedding Si‐CDs in mesoporous aluminas (MAs) is proposed to construct MAs and Si‐CDs composites (Si‐CDs@MAs) with superior luminescence properties. Si‐CDs@MAs phosphor exhibits green emission at 526 nm with narrow full width at half maximum of 51 nm, zero‐thermal quenching even up to 423 K (104.1%@423 K of the emission peak intensity at 298 K), and the internal quantum efficiency of 64.46%. Compared with broad‐band yellow‐emitting solid‐state Si‐CDs (S‐Si‐CDs), the thermal stability, photostability, and water stability of Si‐CDs@MAs phosphor are remarkably improved due to surface protection. The WLED backlight is fabricated with optimized Si‐CDs@MAs phosphor, which shows high luminous efficacy of 117.43 lm W−1and wide color gamut (107% NTSC). Furthermore, this work provides the design principles of realizing stable narrow‐band solid‐state fluorescence carbon dots, suggesting its great potential for wide‐color‐gamut display application.
Systematic assessment of monogenic etiology in adult‐onset kidney stone formers undergoing urological intervention–evidence for genetic pretest probability
Authors: Schönauer Ria , Scherer Lotte , Nemitz‐Kliemchen Melanie , Hagemann Tobias , Hantmann Elena , Seidel Anna , Müller Luise , Kehr Stephanie , Voigt Cornelia , Stolzenburg Jens‐Uwe , Halbritter Jan 
Published: August 2022

AbstractKidney stone disease (KSD) is a prevalent condition associated with high morbidity, frequent recurrence, and progression to chronic kidney disease (CKD). The etiology is multifactorial, depending on environmental and genetic factors. Although monogenic KSD is frequent in children, unbiased prevalence data of heritable forms in adults is scarce. Within 2 years of recruitment, all patients hospitalized for urological kidney stone intervention at our center were consecutively enrolled for targeted next generation sequencing (tNGS). Additionally, clinical and metabolic assessments were performed for genotype–phenotype analyses. The cohort comprised 155 (66%) males and 81 (34%) females, with a mean age at first stone of 47 years (4–86). The diagnostic yield of tNGS was 6.8% (16/236), with cystinuria (SLC3A1, SLC7A9), distal renal tubular acidosis (SLC4A1), and renal phosphate wasting (SLC34A1, SLC9A3R1) as underlying hereditary disorders. While metabolic syndrome traits were associated with late‐onset KSD, hereditary KSD was associated with increased disease severity in terms of early‐onset, frequent recurrence, mildly impaired kidney function, and common bilateral affection. By employing systematic genetic analysis to a less biased cohort of common adult kidney stone formers, we demonstrate its diagnostic value for establishing the underlying disorder in a distinct proportion. Factors determining pretest probability include age at first stone (<40 years), frequent recurrence, mild CKD, and bilateral KSD.
Testing the link between isoaspartate and Alzheimer's disease etiology
Authors: Wang Jijing , Guo Cong , Meng Zhaowei , Zwan Marissa D. , Chen Xin , Seelow Sven , Lundström Susanna L. , Rodin Sergey , Teunissen Charlotte E. , Zubarev Roman A. 
Published: August 2022

AbstractIsoaspartate (isoAsp) is a damaging amino acid residue formed in proteins as a result of spontaneous deamidation. IsoAsp disrupts protein structures, making them prone to aggregation. Here we strengthened the link between isoAsp and Alzheimer's disease (AD) by novel approaches to isoAsp analysis in human serum albumin (HSA), the most abundant blood protein and a major carrier of amyloid beta (Aβ) and phosphorylated tau (p‐tau) in blood. We discovered a reduced amount of anti‐isoAsp antibodies (P < 0.0001), an elevated isoAsp level in HSA (P < 0.001), more HSA aggregates (P < 0.0001), and increased levels of free Aβ (P < 0.01) in AD blood compared to controls. We also found that deamidation significantly reduces HSA capacity to bind with Aβ and p‐tau (P < 0.05). These suggest the presence in AD of a bottleneck in clearance of Aβ and p‐tau, leading to their increased concentrations in the brain and facilitating their aggregations there.
Intracellular Delivery of Glutathione Peroxidase Degrader Induces Ferroptosis In Vivo
Authors: Luo Tianli , Zheng Qizhen , Shao Leihou , Ma Tianyu , Mao Lanqun , Wang Ming 
Published: August 2022

AbstractFerroptosis is a new form of regulated, non‐apoptotic cell death driven by iron‐dependent phospholipid peroxidation. Its therapeutic potential is however, greatly limited by the low efficiency of regulating cell ferroptosis in vivo. Herein, we report a PROTAC‐based protein degrader that depletes endogenous glutathione peroxidase 4 (GPX4) and induces cancer cell ferroptosis. We demonstrate that a rationally designed GPX4 degrader, dGPX4, can deplete tumor cell GPX4 via proteasomal protein degradation, showing a five‐fold enhancement of ferroptosis induction efficiency compared to that of GPX4 inhibition using ML162. Moreover, we show that the intracellular delivery of dGPX4 using biodegradable lipid nanoparticles (dGPX4@401‐TK‐12) induces cell‐selective ferroptosis by targeting cancer cell microenvironment. The in vivo administration of dGPX4@401‐TK‐12 effectively suppresses tumor growth without appreciable side effects. We anticipate the protein degradation strategy described herein could be easily expanded to other essential regulatory proteins of ferroptosis for developing targeted cancer therapeutics.
Rapid and Economical Chemoselective Metabolomics Using Boronate Ester Formation on a Monolithic Substrate
Authors: Wang Xiangyu , Bai Peirong , Li Ziying , Zhu Quan‐Fei , Wei Zhenwei , Feng Yu‐Qi 
Published: August 2022

AbstractAlthough chemoselective labeling strategies show great potential in in‐depth description of metabolomics, the associated time and expense limit applications in high‐throughput and routine analysis. We report a fast and effective chemoselective labeling strategy based on multifunctionalized monolithic probes. A rapid pH‐responsive boronate ester reaction was employed to immobilize and release probe molecules from substrate in 5 min. The mesoporous surface and hierarchically porous channels of the substrate allowed for accelerated labeling reactions. Moreover, the discernible boron beacons allowed for recognition of labeled metabolites with no need for expensive isotopic encoding. This new strategy has been successfully used for submetabolome analysis of yeast cells, serum, and faeces samples, with improved sensitivity for short chain fatty acids up to 1 600 times compared with non‐labeled liquid chromatography–mass spectrometry (LC‐MS) methods.
Synthese des Hexachlorosulfat(IV)‐Dianions ermöglicht durch Polychloridchemie
Authors: Voßnacker Patrick , Wüst Alisa , Müller Carsten , Kleoff Merlin , Riedel Sebastian 
Published: August 2022

AbstractEs wird über die Herstellung und strukturelle Charakterisierung von [NEt3Me]2[SCl6] berichtet. Diese Verbindung ist das erste Beispiel für ein [SCl6]2−‐Dianion und für ein Halogensulfat‐Anion vom Typ [SxXy]z− im Allgemeinen. Das [SCl6]2− gehört zur Gruppe der AB6E‐Systeme mit 14 Valenzelektronen und bildet im festen Zustand eine oktaedrische Struktur aus. Interessanterweise führt die Co‐Kristallisation von CH2Cl2 zur Bildung von [NEt3Me]2[SCl6]⋅4 CH2Cl2 in dem das [SCl6]2−‐Dianion eine C4v‐Symmetrie aufweist. Wie quantenchemische Berechnungen nahelegen, wird die Verzerrung der Struktur nicht durch ein stereochemisch aktives freies Elektronenpaar, sondern durch verstärkte Wasserstoffbrückenbindungen mit CH2Cl2 verursacht. Bei erhöhten Temperaturen zersetzt sich [NEt3Me]2[SCl6] in verschiedene Schwefel‐Chlor‐Verbindungen, wie sich durch Raman‐Spektroskopie nachweisen lässt. Abkühlen auf Raumtemperatur führt zur selektiven Bildung von [NEt3Me]2[SCl6], das mit dem gut untersuchten SCl4 vergleichbar ist.
Megalo‐Kavitanden: Synthese von Acridan[4]arenen und Bildung großer, tiefer Kavitanden für die selektive C70‐Aufnahme
Authors: Pfeuffer‐Rooschüz Jonathan , Heim Salome , Prescimone Alessandro , Tiefenbacher Konrad 
Published: August 2022

AbstractTiefe Kavitanden, konkave molekulare Behälter, stellen eine wichtige supramolekulare Wirtsklasse dar, die für eine Vielzahl von Anwendungen erforscht wurde, die von der Sensorik, Schaltung, Reinigung und Adsorption bis hin zur Katalyse reichen. Eine wesentliche Einschränkung auf diesem Gebiet ist das Kavitandenvolumen, das durch die Größe der verwendeten Strukturplattform (Durchmesser ca. 7 Å) begrenzt ist. Wir berichten hier über die Synthese einer neuartigen, beispiellos großen Strukturplattform namens Acridan[4]aren (Durchmesser ca. 14 Å), die sich für die Konstruktion von Kavitanden mit einem Volumen von bis zu 814 Å3 eignet. Diese Megalo‐Kavitanden dienen als größenselektive Wirte für Fullerene mit einer Bindungsaffinität von mM bis sub‐μM für C60 und C70. Darüber hinaus wurde die selektive Bindung von Fulleren C70 in Gegenwart von C60 nachgewiesen.
Exploiting the Unique Properties of Lanthanide Complexes as FRET Probes: from Quantitation to Protein Dynamics
Authors: Wheeler Simon , Butler Stephen J. 
Published: August 2022

AbstractLanthanide complexes have a range of photophysical properties – large pseudo‐Stokes shifts, narrow linewidths, long emission lifetimes – that make them ideal as emissive probes. These same properties also render them excellent donors in assays relying on Förster resonance energy transfer (FRET). Over the last 20 years these assays have increased in sophistication so that a range of biological applications has now been demonstrated. These range from easy‐to‐use quantitation of proteins (a practical alternative to western blotting) to sophisticated experiments which give real‐time information on the movement of proteins or allow simultaneous readout of both agonist and co‐activator binding to a protein. We introduce the principles and difficulties of using such assays before surveying the full scope of what they can achieve and attempting to anticipate future developments in this area.