bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasonographic evaluation of anterior brain complexes in fetuses with a gestational age between 20-30 week
Authors: Hajalioghli Parisa , Tarzamni Mohammad Kazem , Pashayi Davood , Zarrintan Armin , Movalled Kobra , Ranjkesh Mahnaz 
Published: November 2022

AbstractBackground:In pediatric neurology, Fetal ultrasonography is an useful diagnostic tool. Study of the anterior complex, namely the cavum septum pellucidum.Methods:A total of 106 participants with a gestational age of 20-30 weeks were enrolled. They all evaluated characteristics of the anterior complex by ultrasonographic examination.Results:In our study a total of 106 pregnant women were included, with 58 male fetuses and 48 female fetuses. The mean age of the women participating in the study was 29.7 ± 5.21 years old. In our study among the studied CSPs, 97 cases were rectangular (91.5%) and 9 cases were triangular (8.5%). The mean and standard deviation for the area in the rectangular CSP was 33.04±10.54 mm2 and in the triangular CSP was 21.05±4.18 mm2. In our study, the mean and standard deviation of length to width ratio of CSP was 1.98±0.31. In our study, the mean and standard deviation of length to width ratio of CSP was 1.98±0.31. In all cases where the CSP was triangular-shaped, the triangle's base was observed anteriorly (anterior based). In the implicit evaluation of the geometric dimensions and shape of the CSP with respect to the sex of the embryos examined, it was found that there was no clear relationship between the sex of the fetus and the geometrical shape of the cavum septum. Also, there was no significant relationship between sex of fetus and CSP Ratio.Conclusion:The advancement of gestational age was related to CPS characteristics. This could be used in identifying subjects with increased risk for central nervous system abnormalities.
The Global Dynamic Transmissibility of COVID-19 and its Influencing Factors: an Analysis of Control Measures from 176 Countries
Authors: Wang Hongjian , Lan Yajia 
Published: November 2022

Abstract
Objective To summarise the dynamic characteristics of COVID-19 transmissibility; To analyse and quantify the effect of control measures on controlling the transmissibility of COVID-19; To predict and compare the effectiveness of different control measures.
Methods We used the basic reproduction number (R0) to measure the transmissibility of COVID-19, the transmissibility of COVID-19 and control measures of 176 countries and regions from January 1, 2020 to May 14, 2022 were included in the study. The dynamic characteristics of COVID-19 transmissibility were summaried through descriptive research and a Dynamic Bayesian Network (DBN) model was constructed to quantify the effect of control measures on controlling the transmissibility of COVID-19.
Results The results show that the spatial transmissibility of COVID-19 is high in Asia, Europe and Africa, the temporal transmissibility of COVID-19 rises with the epidemic of Beta and Omicron strains. Dynamic Bayesian Network (DBN) model shows that the transmissibility of COVID-19 is negatively correlated with control measures: Restricting population mobility has the strongest effect, Nucleic Acid Testing (NAT) has a strong effect, and vaccination has the weakest effect.
Conclusion Strict control measures are essential for the control of COVID-19 outbreak; Restricting population mobility and Nucleic Acid Testing have significant impacts on the control of the COVID-19 transmissibility, while vaccination has no significant impact. The development of future control measures may be the large-scale application of new nucleic acid testing technology and the mass popularization of booster immunization.
MBD2 facilitates tumor metastasis by mitigating DDB2 expression
Authors: Zhang Lei , Wang Siyuan , Wu Guo-Rao , Yue Huihui , Dong Ruihan , Zhang Shu , Yu Qilin , Yang Ping , Zhao Jian-ping , Zhang Huilan , Yu Jun , Yuan Xianglin , xiong weining , Yang Xiangliang , Yong Tuying , Wang Cong-Yi 
Published: November 2022

Abstract
Despite past extensive studies, the pathoetiologies underlying tumor metastasis remain poorly understood, which renders its treatment largely unsuccessful. The methyl-CpG-binding domain 2 (MBD2), a “reader” to interpret DNA methylome-encoded information, has been noted to be involved in the development of certain types of tumors, while its exact impact on tumor metastasis remains elusive. Herein we demonstrated that patients with LUAD metastasis were highly correlated with enhanced MBD2 expression. Therefore, knockdown of MBD2 significantly attenuated the migration and invasion of LUAD cells (A549 and H1975 cell lines) coupled with attenuated epithelial–mesenchymal transition (EMT). Moreover, similar results were observed in other types of tumor cells (B16F10). Mechanistically, MBD2 selectively bound to the methylated CpG DNA within the DDB2 promoter, by which MBD2 repressed DDB2 expression to promote tumor metastasis. As a result, administration of MBD2 siRNA-loaded liposomes remarkably suppressed EMT along with attenuated tumor metastasis in the B16F10 tumor-bearing mice. Collectively, our study indicates that MBD2 could be a promising prognostic marker for tumor metastasis, while administration of MBD2 siRNA-loaded liposomes could be a viable therapeutic approach against tumor metastasis in clinical settings.
Challenges of the Integrated Information System (SINA) in Maternity Care
Authors: Meraji Marziyhe , Farkhani Ehsan Mosa , Ramezanghorbani Nahid , Azghandi Akram Forghani , Mahmoodian Sanaz Sadat 
Published: November 2022

Abstract
Background & Aims: The electronic health record software of Mashhad University of Medical Sciences is the Integrated Information system, called “SINA” which was launched in 2016 to enhance public health and manage mother and child information. This study aimed to identify the challenges of “SINA” focusing on the information management of pregnant women from the healthcare midwives’ perspective.
Methods: This qualitative study was conducted on 14 healthcare midwives currently working in the health centers affiliated with Mashhad University of Medical Sciences who were selected through purposeful sampling. Data were collected through in-depthand semi-structured interviews. Data analysis was carried out through thematic content analysis.
Results: The main theme challenges identified from the analyzed data were system management problems and software systems problems. The four subthemes were system flow and process management, structural problems, interface, and technical problems.
Conclusion: Based on the healthcare midwives’ perspectives, Maternity care information and training of pregnant women were well documented in “SINA”. This study can advise the policymakers to succeed in the Practical applications of the “SINA” by enhancing its strong features and ability to handle its challenges.
Long-wave infrared photothermoelectric detectors with ultrahigh polarization sensitivity
Authors: Dai Mingjin , Wang Chongwu , Qiang Bo , Jin Yuhao , Ye Ming , Wang Fakun , Sun Fangyuan , Zhang Xuran , Luo Yu , Wang Qi Jie 
Published: November 2022

Abstract
Filter-free miniaturized polarization-sensitive photodetectors based on anisotropic absorption in natural or artificial birefringent materials have important applications in the next-generation on-chip polarimeters. However, their polarization sensitivity, which is a key parameter based on polarization ratio (PR) and responsivity, is thus far limited by the intrinsic low diattenuation and inefficient photon-to-electron conversion. To tackle these challenges, we implement experimentally a miniaturized detector based on one-dimensional (1D) tellurium nanoribbon, which can significantly improve the photothermoelectric responses by translating the polarization-sensitive absorption into a large temperature gradient and combining the finite-size effect of perfect plasmonic absorber. Our devices work at room-temperature with a zero-bias responsivity of 410 V/W and an infinite polarization ratio (PR=∞). A peak polarization angle sensitivity of 7.10 V/W•degree, which is one order of magnitude higher than those reported in the literature, is observed in the long-wave infrared region (λ = 8.0 µm). The proposed device can simultaneously achieve full linear polarimetry detection of the power intensity, polarization angle, and linear polarization degree, with its simple geometrical configuration. To demonstrate its potentials in practical applications, we apply our polarization-sensitive photodetector to polarization-coded communication and optical strain measurement. Our work offers a feasible solution to develop miniaturized room-temperature photodetectors with ultrahigh polarization sensitivity at the long-wave infrared. The approach proposed here can be easily extended to other frequencies by simply adjusting the resonance wavelength of the plasmonic metamaterials.
Analysis of Potato Physiological and Biochemical Adaptable Mechanism in Response to Water and Nitrogen Interaction
Authors: Yan Wenyuan , qin Junhong , Jian Yinqiao , Liu Jiangang , Bian Chunsong , Jin Liping , Li Guangcun 
Published: November 2022

Abstract
Aims
Water and nitrogen are essential for potato growth and development. To understand how potato adapts to changes in soil water and nitrogen content.
Methods
Potato plant adaptations to changes in soil moisture and nitrogen levels were analyzed at the physiological and transcriptomic levels in four treatment groups: adequate nitrogen under drought, adequate nitrogen under sufficient irrigation, limited nitrogen under drought, and limited nitrogen under sufficient irrigation.
Results
Many light-capture pigment complex genes and oxygen release complex genes were differentially expressed in leaves when nitrogen levels were increased under drought conditions, and several genes encoding rate-limiting enzymes in the Calvin–Benson–Bassham cycle were up-regulated; furthermore, leaf stomatal conductance decreased, whereas the saturated vapor pressure difference and relative chlorophyll content in the chloroplasts increased. StSP6A, a key gene in potato tuber formation, was down-regulated in response to increased nitrogen application, and the stolon growth time was prolonged. Genes related to root nitrogen metabolism were highly expressed, and protein content in the tuber increased. Weighted gene co-expression network analysis (WGCNA) revealed 32 gene expression modules and 34 key candidate genes that responded to changes in water and nitrogen levels.
Conclusions
High nitrogen levels prolonged the stolon growing period. Under drought conditions, increasing nitrogen levels increased light energy conversion efficiency and tuber protein content. A total of 34 key candidate genes were identified and a preliminary molecular model of potato responses to alterations in soil water and nitrogen content was constructed.
Investigating the impact of an online hydration intervention in care homes using the COM-B model: a mixed methods study
Authors: McMichael Danielle , Gillen Patricia , McGeary Caroline , Sartaj Muhammad , Patterson Lynsey 
Published: November 2022

Abstract
Background
Antimicrobial resistance is a serious threat to public health. To reduce antimicrobial resistance, interventions to reduce gram-negative infections, specifically urinary tract infections, are vital. Early evidence suggests increased fluid intake is linked with a reduction in UTIs and subsequently has potential to reduce antibiotic usage. Care homes have a high prevalence of UTIs and provide an opportunity in a closed setting to deliver an intervention focused on increasing fluid intake, where it is support and monitored by health care workers. We aimed to evaluate the impact of a staff focused intervention to increase the hydration of care home residents and the possible impact on the number of residents who have UTIs.
Methods
The study was a pre and post intervention with a sequential explanatory mixed methods design. The intervention was delivered online in 3 care homes and contained 3 main components underpinned by the COM-B model including hydration training, 7 structured drinks rounds and a hydration champion to change behaviour of care home staff. A pre and post questionnaire assessed the impact of the intervention on staff and data was collected on fluid intake, drinks rounds delivered to residents, UTIs, antibiotic used to treat UTIs, falls and hospitalisation. Descriptive statistics including counts, percentages and the median summarised and assessed the impact of the study. Focus groups with care home staff provided qualitative data which was thematically analysed.
Results
Staff had an increase in knowledge across the six components of hydration care. 59% of residents had an increase in median fluid intake post intervention. During the time of the intervention, a 13% decrease in UTIs and antibiotic usage to treat UTIs across the 3 care homes was recorded, however falls and hospitalisations increased. Staff mostly found the intervention enjoyable and useful, with 90% reporting they would make a change to their daily practice.
Conclusions
This study demonstrates that a brief, low cost, online multi-component intervention focused on care home staff can increase the fluid intake of residents. A reduction in UTIs and antibiotic consumption was observed overall. Empowering care home staff could be a way of reducing the burden of infection in this setting.
Preliminary evaluation of SaCoVLM video laryngeal mask-guided intubation in airway management for anesthetized children
Authors: Zhi Juan , Yang Dong , Deng Xiao-Ming , Zhang Yan-Ming , Wei Ling-Xin , Wang Qian-Yu 
Published: November 2022

Abstract
Backgrounds: To preliminary evaluate the application of novel SaCoVLM video laryngeal mask -guided intubation for anesthetized children.
Methods:.124 children with microtia (ages 5-15years,) who required general intubation anaesthesia, were enrolled in the study. After induction of general anesthesia,guided tracheal intubation under direct vision of the SaCoVLM was performed. Our primary outcome was first-pass success rate of guided tracheal tube placement. Secondary outcome included glottic visualization grades, the first-attempt success rate of LMA placement, the time for LMA placement and time to endotracheal intubation as well as the time for LMA removal after successful intubation, the fiberoptic grade of laryngeal view, the baseline and postinduction hemodynamic parameters were also recorded,and the incidence 24h complications after operation.
Results: The first-pass success rate of guided tracheal tube placement was 91.1%（95%CI=1.04-1.14）, the status of glottic visualization was classified:grade 1 in 27cases,grade 2 in 36 cases,grade 3 in 41 cases and grade 4 in 20 cases. the first success rate of LMA placement was 92.7%（95%CI=1.03-1.13）,the time for LMA insertion was 15.7(±9.1)s,intubation time was 30.9(±17.6)s and withdrawl time was 24.9(±9.3)s, the MAP value was higher after intubation than before intubation(p<0.05),The incidence of postoperative sore throat at 2h was 29%, and 16.1% at 24h,without dysphagia and hypoxia.
Conclusion:The SaCoVLM video laryngeal mask-guided intubation is feasible in children, with a high success rate ,could be a new promising device to guide intubation in airway management.
A note on “Optimal solution of neutrosophic linear fractional programming problems with mixed constraints”
Authors: Tomar Parul , Kumar Amit 
Published: November 2022

Abstract
Das and Edalatpanah (Soft Comput 26 (2022) 8699–8707) proposed an approach to find an optimal solution of neutrosophic linear fractional programming problems with mixed constraints (linear programming problems with mixed constraints in which each decision variable is represented by a non-negative real number and each other parameter is represented by a triangular neutrosophic number). In this paper, it is pointed out that a mathematical incorrect result is considered in Das and Edalatpanah’s approach. Hence, it is inappropriate to use Das and Edalatpanah’s approach. Also, Das and Edalatpanah’s approach is modified to resolve its inappropriateness.
[18F]FDG dose de-escalation and shortened acquisition duration using total-body PET/CT in pediatric tumor imaging: a prospective pilot study
Authors: Hu Ying-Ying , Liu Lei , Chen Wanqi , Tang Si , Li Zhijian , Zhang Weiguang , Zhang Xu , Feng Jiatai , Sun Hongyan , Wu Runze , Wei Fan , Zhao Yumo 
Published: November 2022

Abstract
Purpose

To characterize the diagnostic performance of [18F]FDG dose de-escalation with shortened acquisition times using total-body PET/CT in pediatric tumor imaging in terms of the subjective image quality and quantification of tracer uptake.

Methods

In this single-center prospective study, 31 pediatric oncology patients under 14 years old were enrolled and underwent total-body PET/CT using the uEXPLORER PET/CT scanner. All patients were randomly assigned to one of four [18F]FDG dose groups: full-dose (3.7 MBq/kg), 1/2-dose (1.9 MBq/kg), 1/3-dose (1.2 MBq/kg), and 1/4-dose (0.9 MBq/kg). Images with a shortened acquisition time frame (20 min, 12 min, 10 min, 8 min, 6 min, 5 min, 4 min, 3 min, 2 min, 1.5 min, 1 min, and 0.5 min) were reconstructed for each study, with the 20-min images as controls for each dose group. Semiquantitative uptake metrics were assessed using region-of-interest (ROI) analysis of healthy liver and suspected lesions. The subjective analysis was performed using 5-point Likert scales. Suspected major lesions and microlesions were recorded, while 3-point Likert scales were used for diagnostic confidence.

Results

With shortened acquisition times, the liver maximum standard uptake value (SUVmax) and standard deviation (SD) increased in each dose group. The signal-to-noise ratio (SNR) was significantly reduced with shortened acquisition time, while the lesion SUVmax and tumor-to-background ratio (TBR) showed no significant deviation. A decent subjective image quality score could be achieved in the full-, 1/2-, 1/3-, and 1/4-dose groups with at least 2-min, 4-min, 6-min, and 8-min acquisitions, respectively, where great overall image quality and brain delineation (scored 5.0) and superior organ boundaries and image noise (scored over 4.0) could be achieved, and all suspicious lesions found in 20-min images were detectable with high diagnostic confidence.

Conclusions

The regimen of full-dose [18F] FDG with a 2-min scan, 1/2-dose with a 4-min scan, 1/3-dose with a 6-min scan, and 1/4-dose with an 8-min scan using total-body PET/CT can provide great image qualities, can maintain a desired diagnostic performance and is feasible for pediatric oncological clinical applications.
Trial registration: ChiCTR2000036334. Registered 22 August 2020.
Gender difference in the burden of urogenital congenital anomalies at global, regional, and national levels from 1990 to 2019: results from the Global Burden of Disease Study 2021
Authors: Huang Xiaoyu , Tang Jianming , Chen Mao , Xiao Ya , Zhu Fangyi , Chen Liying , Tian Xiaoyu , Hong Li 
Published: November 2022

Abstract
Aims. Urogenital congenital anomalies(UCAs) involve both urinary tract and/or genital tract congenital malformations, which may cause severe neonatal death. This research aimed to reveal the latest magnitudes and temporal trends of geographical distribution for UCA burden and their gender difference to help develop more detailed prevention and intervention policies.
Methods. The data for the disease burden of UCAs from 1990 to 2019 was exacted from the Global Burden of Disease Study 2019. The average annual percentage change was calculated to quantify the secular trends in age-standardized rates (ASRs) of UCA burden. Meanwhile, a cross-sectional comparison of the disease burden was made at the time points of 1990 and 2019.
Results. In 2019, there were an estimated 1.13×106 [95% uncertainty interval (UI) 0.795-1.62] incident cases of UCA, 6.28×106 [95% UI 4.98-7.72] prevalent cases and 1.09×106 [95% UI 0.832-1.41] disabilityadjusted life years(DALYs) globally. For female UCAs, there were an estimated 0.559×106 [95% UI 0.392-0.790] incident cases, 3.17×106 [95% UI 2.53-3.88] prevalent cases and 0.438×106 [95% UI 0.302-0.604] DALYs. For male UCAs, there were an estimated 0.576×106 [95% UI 0.405-0.833] incident cases, 3.11×106 [95% UI 2.45-3.83] prevalent cases and 0.657×106 [95% UI 0.435- 0.925] DALYs.
Conclusions. Our analysis confirms that UCAs are an underestimated public children's health concern. There was a slight upward trend of prevalence and incidence rates for UCAs, whereas the deaths rate and DALYs rates both showed relatively decreasing trends over the past 30 years globally. These substantial heterogeneities in the UCA burden worldwide and giant differences in the female and male cases highlight the need to detect the potentially influential factors for the UCA and devise suitable policies and provide specific clinical research.
Reparative Calcified Barrier Characterization after Mixing Injectable-Platelet Rich Fibrin with Bioactive Direct Pulp Capping Agents; An Exp. Study.
Authors: mansour nirvana 
Published: November 2022

Abstract

Aim: This study investigated the morphology and localization of hard tissue barriers formed after direct pulp capping using i-PRF mixed with bioactive agents (Mineral Trioxide Aggregate (MTA) and Bioactive Bone Graft (BBG)) in dogs' teeth using Scanning Electron Microscope.Materials and methods:A total of 64 teeth were used out of 8 healthy male mongrel dogs. The teeth were randomly assigned into four groups according to capping agents used, they were exposed and capped as follow, Group A; capped with MTA, Group B; capped with MTA+ i-PRF, Group C; capped with BBG, Group D; capped with BBG + i-PRF. Finally the access cavity was restored with Intermediate Restorative Material (IRM). The dogs were euthanized after 1 month; and samples were then prepared for scanning electron microscopic study. SEM was used to assess the morphology, localization and extension of the reparative hard tissue barriers and using an image-processing and analysis software to delimit the perimeters of the root canal area and the hard tissue barrier to determine the percentage of root canal obliteration. Chi-square test was used for intragroup comparisons. Results showed that all groups were statistically different (P < 0.05), regarding tissue barrier morphology.Conclusion: Addition of i-PRF to pulp capping agents allows production of peripheral hard tissue barriers with more dentinal tubules.