bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bichromatic state-dependent disordered potential for Anderson localization of ultracold atoms
Authors: Lecoutre Baptiste , Guo Yukun , Yu Xudong , Niranjan M. , Mukhtar Musawwadah , Volchkov Valentin V. , Aspect Alain , Josse Vincent 
Published: November 2022

Abstract
The ability to load ultracold atoms at a well-defined energy in a disordered potential is a crucial tool to study quantum transport, and in particular Anderson localization. In this paper, we present a new method for achieving that goal by rf transfer of atoms in an atomic Bose-Einstein condensate from a disorder-insensitive state to a disorder-sensitive state. It is based on a bichromatic laser speckle pattern, produced by two lasers whose frequencies are chosen so that their light-shifts cancel each other in the first state and add up in the second state. Moreover, the spontaneous scattering rate in the disorder-sensitive state is low enough to allow for long observation times of quantum transport in that state. We theoretically and experimentally study the characteristics of the resulting potential.

Graphic abstract
Thermal evolution and resources of the Bowland Basin (NW England) from apatite fission-track analyses and multidimensional basin modelling
Authors: Lodhia Bhavik Harish , Parent Adeline , Fraser Alastair J. , Nuemaier Martin , Hennissen Jan A. I. 
Published: November 2022

Abstract

Once highlighted for having significant shale gas resource potential, the Bowland Basin has been at the centre of both scientific and political controversy over the last decade. Previous shale gas resource estimates range from 10
3
to 10
1
TCF. Repeated events of induced seismicity following hydraulic fracturing operations led to an indefinite government moratorium and abandonment of operations across the mainland UK. We use apatite fission-track analyses to investigate the magnitude and timing of post-Triassic uplift and exhumation. Results indicate that maximum palaeotemperatures of 90–100°C were reached in the stratigraphically younger Sherwood Sandstone. We combine palaeotemperature predictions to constrain palaeo heat flow and erosion in regional basin models for the first time. Our results indicate variable maximum Late Cretaceous palaeo heat flow values of 62.5–80 mW m
−2
and the removal of 800–1500 m of post-Triassic strata at wells across the basin. Regional 2D basin modelling indicates a gas-in-place estimate of 131 ± 64 TCF for the Bowland Shale. This reduces to a resource potential of 13.1 ± 6.4 TCF, assuming a recovery factor of 10%. These values are significantly lower than previous resource estimates and reflect the highly complex nature of the Bowland Basin and relatively unknown history of post-Triassic uplift, exhumation and erosion.
Survey of Hallucination in Natural Language Generation
Authors: Ji Ziwei , Lee Nayeon , Frieske Rita , Yu Tiezheng , Su Dan , Xu Yan , Ishii Etsuko , Bang Ye Jin , Madotto Andrea , Fung Pascale 
Published: November 2022

Natural Language Generation (NLG) has improved exponentially in recent years thanks to the development of sequence-to-sequence deep learning technologies such as Transformer-based language models. This advancement has led to more fluent and coherent NLG, leading to improved development in downstream tasks such as abstractive summarization, dialogue generation, and data-to-text generation. However, it is also apparent that deep learning based generation is prone to hallucinate unintended text, which degrades the system performance and fails to meet user expectations in many real-world scenarios. To address this issue, many studies have been presented in measuring and mitigating hallucinated texts, but these have never been reviewed in a comprehensive manner before.In this survey, we thus provide a broad overview of the research progress and challenges in the hallucination problem in NLG. The survey is organized into two parts: (1) a general overview of metrics, mitigation methods, and future directions, and (2) an overview of task-specific research progress on hallucinations in the following downstream tasks, namely abstractive summarization, dialogue generation, generative question answering, data-to-text generation, and machine translation. This survey serves to facilitate collaborative efforts among researchers in tackling the challenge of hallucinated texts in NLG.
Molecularly Defined Subsets of Ewing Sarcoma Tumors Differ in Their Responses to IGF1R and WEE1 Inhibition
Authors: Soni Upendra Kumar , Wang Yuhua , Pandey Ram Naresh , Roberts Ryan , Pressey Joseph G. , Hegde Rashmi S. 
Published: November 2022

Abstract

Purpose:
Targeted cancer therapeutics have not significantly benefited patients with Ewing sarcoma with metastatic or relapsed disease. Understanding the molecular underpinnings of drug resistance can lead to biomarker-driven treatment selection.

Experimental Design:
Receptor tyrosine kinase (RTK) pathway activation was analyzed in tumor cells derived from a panel of Ewing sarcoma tumors, including primary and metastatic tumors from the same patient. Phospho-RTK arrays, Western blots, and IHC were used. Protein localization and the levels of key markers were determined using immunofluorescence. DNA damage tolerance was measured through PCNA ubiquitination levels and the DNA fiber assay. Effects of pharmacologic inhibition were assessed in vitro and key results validated in vivo using patient-derived xenografts.

Results:
Ewing sarcoma tumors fell into two groups. In one, IGF1R was predominantly nuclear (nIGF1R), DNA damage tolerance pathway was upregulated, and cells had low replication stress and RRM2B levels and high levels of WEE1 and RAD21. These tumors were relatively insensitive to IGF1R inhibition. The second group had high replication stress and RRM2B, low levels of WEE1 and RAD21, membrane-associated IGF1R (mIGF1R) signaling, and sensitivity to IGF1R or WEE1-targeted inhibitors. Moreover, the matched primary and metastatic tumors differed in IGF1R localization, levels of replication stress, and inhibitor sensitivity. In all instances, combined IGF1R and WEE1 inhibition led to tumor regression.

Conclusions:
IGF1R signaling mechanisms and replication stress levels can vary among Ewing sarcoma tumors (including in the same patient), influencing the effects of IGF1R and WEE1 treatment. These findings make the case for using biopsy-derived predictive biomarkers at multiple stages of Ewing sarcoma disease management.
ApoA-I Nanotherapy Rescues Postischemic Vascular Maladaptation by Modulating Endothelial Cell and Macrophage Phenotypes in Type 2 Diabetic Mice
Authors: Babu Mohan , Devi Durga , Mäkinen Petri , Örd Tiit , Aavik Einari , Kaikkonen Minna , Ylä-Herttuala Seppo 
Published: November 2022

Background:
Diabetes is a major risk factor for peripheral arterial disease. Clinical and preclinical studies suggest an impaired collateral remodeling and angiogenesis in response to atherosclerotic arterial occlusion in diabetic conditions, although the underlying mechanisms are poorly understood.

Objective:
To clarify the cellular and molecular mechanisms underlying impaired postischemic adaptive vascular responses and to evaluate rHDL (reconstituted HDL)-ApoA-I nanotherapy to rescue the defect in type 2 diabetic mouse model of hindlimb ischemia.

Methods and Results:
Hindlimb ischemia was induced by unilateral femoral artery ligation. Collateral and capillary parameters together with blood flow recovery were analyzed from normoxic adductor and ischemic gastrocnemius muscles, respectively, at day 3 and 7 post-ligation. In response to femoral artery ligation, collateral lumen area was significantly reduced in normoxic adductor muscles. Distally, ischemic gastrocnemius muscles displayed impaired perfusion recovery and angiogenesis paralleled with persistent inflammation. Muscle-specific mRNA sequencing revealed differential expression of genes critical for smooth muscle proliferation and sprouting angiogenesis in normoxic adductor and ischemic gastrocnemius, respectively, at day 7 post-ligation. Genes typical for macrophage (Mϕ) subsets were differentially expressed across both muscle types. Cell-specific gene expression, flow cytometry, and immunohistochemistry revealed persistent IFN-I response gene upregulation in arterial endothelial cells, ECs and Mϕs from T2DM mice associated with impaired collateral remodeling, angiogenesis and perfusion recovery. Furthermore, rHDL nanotherapy rescued impaired collateral remodeling and angiogenesis through dampening EC and Mϕ inflammation in T2DM mice.

Conclusions:
Our results suggest that an impaired collateral remodeling and sprouting angiogenesis in T2DM mice is associated with persistent IFN-I response in ECs and Mϕs. Dampening persistent inflammation and skewing ECs and Mϕ phenotype toward less inflammatory ones using rHDL nanotherapy may serve as a potential therapeutic target for T2DM peripheral arterial disease.
Association of Home and Ambulatory Blood Pressure With Cardiovascular Prognosis in Practice Hypertensive Outpatients
Authors: Narita Keisuke , Hoshide Satoshi , Kario Kazuomi 
Published: November 2022

Background:
Although international guidelines for hypertension management recommend home and ambulatory blood pressure (BP) monitoring, few studies have assessed which is more useful in predicting cardiovascular incidence in hypertensive outpatients.

Methods:
We analyzed the association of home and ambulatory BP with cardiovascular prognosis in 1336 practice outpatients with hypertension who underwent both home and ambulatory BP measurements in the J-HOP study (Japan Morning Surge-Home Blood Pressure).

Results:
During the median 6.9 years of follow-up, 111 cardiovascular events occurred. Both home and ambulatory systolic BP (SBP) were associated with cardiovascular risk independent of office SBP (hazard ratio [95% CI] per 20 mm Hg of average morning and evening home SBP, 1.46 [1.11–1.93]; 24-hour ambulatory SBP, 1.41 [1.02–1.94]). Moreover, average morning and evening home SBP was also associated with cardiovascular risk even adjusted by 24-hour ambulatory SBP (hazard ratio [95%CI] per 20 mm Hg, 1.38 [1.01–1.87]), but 24-hour ambulatory SBP was not associated with cardiovascular risk adjusted by average morning and evening home SBP. Regarding this relationship, the model-fit was significantly improved by using the analysis of likelihood ratio, but that was not significant in the analysis using C statistics. Additionally, even in patients with well-controlled 24-hour ambulatory BP, uncontrolled morning home BP was associated with cardiovascular risks (hazard ratio [95% CI], 2.15 [1.02–4.50]). In patients with well-controlled average morning and evening home BP, uncontrolled ambulatory BP was not associated with cardiovascular risks.

Conclusions:
This study demonstrated the prognostic values of home and ambulatory BP in practice hypertensive outpatients. Our findings indicated the modest superiority of home BP compared to ambulatory BP to predict cardiovascular prognosis.
Examining the reliability and validity of the ICD-11 personality disorder severity diagnosis
Authors: Brown Tiffany A , Sellbom Martin 
Published: November 2022

Objectives: The International Classification of Diseases, 11th edition includes a new personality disorder diagnosis, in light of growing concerns of the categorical personality disorder diagnoses. The purpose of the current study was to examine the reliability and validity of the severity dimension of the new International Classification of Diseases, 11th edition diagnosis, through multi-method assessment. Method: In a community mental health sample ( n = 311), we examined the interrater reliability of the severity diagnosis and evaluated the diagnosis against self-report measures of dimensional personality pathology and psychopathology constructs and traditional categorical and informant-report measures. Results: Intraclass correlations indicated ‘excellent’ reliability of the diagnostic ratings. Large associations were observed between the International Classification of Diseases, 11th edition clinician diagnosis and overall impairment measures. Generally, the International Classification of Diseases, 11th edition clinician diagnosis exhibited largest associations with measures of internalising dysfunction, and more variable associations with interpersonal and externalising impairment. The International Classification of Diseases, 11th edition clinician diagnosis showed a large association with borderline personality disorder symptom scores and moderate associations with Paranoid, Schizoid and Avoidant personality disorder scores. Similar patterns emerged of the associations between the International Classification of Diseases, 11th edition personality disorder diagnosis with self-report and informant-report measures, although the associations were larger with self-report measures. Conclusion: These findings provide promising initial evidence for the reliability and validity of the new International Classification of Diseases, 11th edition personality disorder diagnosis, indicating that the new conceptualisation of personality disorders may address issues within the categorical model.
Religiousness and psychotic experiences among young adult college students in the United States
Authors: Oh Hans Y , Davis Edward B , Klaunig Mallory , Narita Zui , Koyanagi Ai , Karcher Nicole R 
Published: November 2022

Background: Religiousness and psychotic experiences have been related, though findings have been mixed, with little attention paid to specific religious affiliations and religious importance. Methods: We analyzed data from the Healthy Minds Study (2020–2021), which was an online survey administered at 140 college campuses across the United States. We used multivariable logistic regression to examine the associations between religiousness (affiliation and importance) and 12-month psychotic experiences, adjusting for age, gender, and race/ethnicity. Results: Only Christian religious affiliation was associated with lower odds of psychotic experiences (aOR: 0.79; 95% CI: 0.75, 0.84), while Non-Christian religious affiliation (aOR: 1.34; 95% CI: 1.19, 1.50) and Multiple religious affiliation s were associated with greater odds (aOR: 1.28; 95% CI: 1.15, 1.42). Overall, increased religious importance was associated with lower odds of psychotic experiences (aOR: 0.96; 95% CI: 0.94–0.99). After stratifying by affiliation, religious importance was only associated with lower odds of psychotic experiences among people who identified as Other Christian, Mormon, and Other World Religion. Religious importance was associated with greater odds of psychotic experiences among Atheists, Agnostics, Buddhists, Nothing in Particular, and Multiple Religions. Conclusion: Religious affiliation and importance had varying associations with psychotic experiences, depending on type of religious affiliation. More research is needed to explore the modifying effects of religiousness. Responsiveness to religious beliefs and practices may be critical when assessing risk for psychosis.
Need-based rehabilitation program for women with mental illness under long-term admission in a Tertiary Care Hospital: A feasibility study
Authors: Conger Lydia R. , Jagannathan Aarti , Angothu Hareesh , Reddy Shanivaram 
Published: November 2022

Background: In keeping with the rights perspective, the rehabilitation needs of the women under long-term admission (LTA) in ‘closed wards’ of Tertiary Care Hospitals (TCHs) are different, often unfulfilled, and need to be addressed. Methodology: The study used a qualitative exploratory research design. In phase, I, the rehabilitation needs of Women with Mental Illness (WMI) were assessed. In phase II, a rehabilitation program was developed and implemented in the ward where WMI were admitted. In phase III, the feasibility of the implementation of the Rehabilitation Program was tested. Results: The needs expressed by WMI were personal, economic, vocational, social, emotional, educational, relationship, recreation, reintegration, and health needs. They also expressed needs related to their rights such as privacy, making personal choices, access to mobile phones, holding bank accounts, etc. The stakeholders felt that WMIs who get well should be segregated from people who are acutely ill and given access to interact with other groups of people. Based on the themes elicited, a rehabilitation program was developed and implemented through networking and liaising with various departments of the institute, other Government, Non-Governmental Organizations, volunteers, and corporates. The rehabilitation program was found to be feasible with systemic changes being brought about at the institutional level. Conclusion: In keeping with a rights-based approach TCHs need to implement need-based rehabilitation programs for WMI under LTA to improve their living conditions and quality of life
Automated Economic Welfare for Everyone? Examining Barriers to Adopting Robo-Advisors from the Perspective of Explainable Artificial Intelligence
Authors: Digmayer Claas 
Published: November 2022

Robo-advisors (RAs) support economic decisions for customers using artificial intelligence (AI). RAs are gaining increasing significance but lack market penetration. A significant issue is the perceived low transparency of such AI systems. This study examines the public’s demands on RAs with text-mining methods from the perspective of explainable artificial intelligence (XAI). The results reveal understandability and trustworthiness issues for each of the RA use phases (configuration, matching, and maintenance). In particular, five barriers emerge in RA if information needs remain unanswered: entry barrier, assessment barrier, evaluation barrier, continuation barrier and withdrawal barrier. The barriers can be mitigated by combining explanation, design and communication measures. The results are discussed regarding theoretical implications and practical recommendations for facilitating the adoption of RAs. JEL: D8 (D81, D83, D89), G1 (G11), G2 (G20, G23), G4 (G41), I2 (I24, I25), O3 (O31, O33)
The association between preoperative blood calcium and postoperative blood loss in patients undergoing heart valve replacement surgery
Authors: Li Mingke , Dai Yawei , Hu Shuai , Li Yansong , Lu Dasheng , Zheng Rui , Wang Kai 
Published: November 2022

Introduction Bleeding after heart valve surgery is a serious clinical challenge. Hypocalcemia has been associated with the extent of bleeding in patients with spontaneous intracerebral hemorrhage. However, the association between blood calcium levels and bleeding extent in heart valve replacement patients has not been clearly established. This study aimed at determining the association between blood calcium levels and perioperative hemorrhage after heart valve replacement therapy. Methods Based on preoperative blood calcium levels, patients were grouped into the hypocalcemia group and normocalcemia group. Postoperative bleeding, blood product use, and complications were monitored during hospitalization. The association between blood calcium levels and major bleeding was determined by multivariable logistic regression models. Results In the first 12 h after surgery, bleeding in hypocalcemia group was significantly larger than that of the normocalcemia group (338 ± 234 mL vs 232 ± 96 mL; p = .024). The outcome was the same when the overall chest tube output was considered (950 ± 447 mL vs 738 ± 220 mL; p = .038). The incidence of major bleeding was 65.91% in the hypocalcemia group and 18.97% in the normocalcemia group ( p = .001). Postoperative complications in the two groups were similar. After adjusting for multiple covariates, the adjusted odds ratios (OR) for participants in hypocalcemia group was 10.01 (95% CI 3.35–34.82), compared with that in normocalcemia group ( p < .001). Conclusion In patients undergoing heart valve surgery, preoperative blood concentrations of calcium are associated with postoperative blood loss. Hypocalcemia before operation may increase the risk of postoperative bleeding. When patients with valvular heart disease present with hypocalcemia before surgery, prompt intervention may lead to better control of postoperative bleeding.
Compression properties of carbon fiber reinforced polymer grid sandwich structure
Authors: Wei Shiyi , Guo Zhangxin , Shi Haolin , Chai Gin Boay , Li Yongcun , Luan Yunbo 
Published: November 2022

Carbon fiber reinforced polymer (CFRP) grid sandwich structure with four different grid configurations was prepared using the interlocking assembly process in the present work. All test specimens were subjected to quasi-static out-of-plane uniform compression. The equivalent density, height, geometric configuration, and other factors of the structural core layer were analyzed, and their effects on the failure mode, damage mechanism, and energy absorption characteristics of CFRP grid sandwich structure were discussed. The results showed that there are four distinct stages in the load versus displacement curve of CFRP grid sandwich structure specimens subjected to uniform compression, namely, preloading stage, elastic stage, load drop stage, and platform stage. The main failure modes of CFRP grid sandwich structure are the local buckling and compression fracture of the core rib. The failure load, compression strength, breaking absorbed energy, and specific absorbed energy of CFRP grid sandwich structure are positively correlated with the equivalent density of the structure core layer, and negatively correlated with the height of the structure core layer. When the equivalent density of the core layer of the Mixed CFRP grid sandwich structure was increased by 10 kg/m3, the compressive strength and specific energy absorption of the structure increased by about 5.08 MPa and 186.79 mJ, respectively, and when the core layer height was increased by 10 mm, the compressive strength and specific energy absorption decreased by about 12.04 MPa and 67.39 mJ, respectively; The strength and stability of the Mixed CFRP grid sandwich structure are significantly higher than those of the Triangular, Diamond, and Square CFRP grid sandwich structures.
Infant Exposure to Armodafinil Through Human Milk Following Maternal Use of Modafinil
Authors: Leggett Catherine , Ritchie Usha , Costi Lynn , Elliot David , Mangoni Arduino A , Hague William M. 
Published: November 2022

Introduction Narcolepsy, a condition adversely affecting psychological, social, and cognitive function, is more prevalent in females of childbearing age than the general population. Modafinil and armodafinil are central nervous system stimulants approved for treatment of narcolepsy. Infant exposure to these agents through human milk has not been investigated. Poor quality medication safety information during lactation is associated with early cessation of breastfeeding and suboptimal healthcare for the breastfeeding family. Main Issue In this case study, we measured the concentration of armodafinil (the most active form of modafinil) in human milk and infant plasma to quantify infant exposure. Management The participant was a 30-year-old primipara with narcolepsy, taking modafinil (300 mg morning, 100 mg noon) while breastfeeding her 6-week-old infant despite the paucity of safety information. Armodafinil concentrations were measured in eight serial human milk samples collected over a 26-hr period and in single maternal and infant plasma samples using ultra performance liquid chromatography - tandem mass spectrometry. The average concentration of armodafinil in human milk was 1.96 mg/L; the relative infant dose was 4.85%; the theoretical infant dose was 0.294 mg/kg/day. Maternal and infant plasma concentrations of armodafinil were 12.02 mg/L and 0.19 mg/L, respectively. The participant continued to exclusively breastfeed the infant, who had normal growth and development. Conclusion Based on these findings, relatively small amounts of armodafinil pass into human milk, with consequent limited infant exposure. Consideration can be given to the use of modafinil or armodafinil during breastfeeding, provided the infant is monitored. Further studies are needed to confirm these findings.