bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prescribing Patterns of Sodium-Glucose Cotransporter-2 Inhibitors in Patients with CKD: A Cross-Sectional Registry Analysis
Authors: Zhuo Min , Li Jiahua , Buckley Leo F. , Tummalapalli Sri Lekha , Mount David B. , Steele David J.R. , Lucier David J. , Mendu Mallika L. 
Published: January 2022

Key Points

The prescribing patterns of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) in the CKD population remain largely unknown.Prescription of SGLT-2i was low in patients with CKD, particularly those without diabetes.Younger Black men with a history of heart failure and cardiologist visit were associated with higher odds of SGLT-2i prescription.

Background
Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) reduce kidney disease progression and mortality in patients with chronic kidney disease (CKD), regardless of diabetes status. However, the prescribing patterns of these novel therapeutics in the CKD population in real-world settings remain largely unknown.

Methods
This cross-sectional study included adults with stages 3–5 CKD included in the Mass General Brigham (MGB) CKD registry in March 2021. We described the adoption of SGLT-2i therapy and evaluated factors associated with SGLT-2i prescription using multivariable logistic regression models in the CKD population, with and without diabetes.

Results
A total of 72,240 patients with CKD met the inclusion criteria, 31,688 (44%) of whom were men and 61,265 (85%) White. A total of 22,653 (31%) patients were in the diabetic cohort, and 49,587 (69%) were in the nondiabetic cohort. SGLT-2i prescription was 6% in the diabetic cohort and 0.3% in the nondiabetic cohort. In multivariable analyses, younger Black men with a history of heart failure, use of cardiovascular medications, and at least one cardiologist visit in the previous year were associated with higher odds of SGLT-2i prescription in both diabetic and nondiabetic cohorts. Among patients with diabetes, advanced CKD stages were associated with lower odds of SGLT-2i prescription, whereas urine dipstick test and at least one subspecialist visit in the previous year were associated with higher odds of SGLT-2i prescription. In the nondiabetic cohort, CKD stage, urine dipstick test, and at least one nephrologist visit in the previous year were not significantly associated with SGLT-2i prescription.

Conclusions
In this registry study, prescription of SGLT-2i was low in the CKD population, particularly among patients without diabetes.
RAUL DA FERRUGEM AZUL: DISCUTINDO O PAPEL DO ESPECTADOR DE BULLYING A PARTIR DA LITERATURA
Authors: Medeiros Lívia Cristina Cortez Lula de 
Published: January 2022

O artigo é recorte de uma tese de doutorado vinculada à Universidade Federal do Rio Grande do Norte (UFRN). Seu objetivo é apresentar como a leitura de literatura pode ser trabalhada para se discutir o papel dos espectadores em situações de bullying entre escolares, levando-os a refletirem sobre a violência entre pares. Nesse estudo, o foco da discussão recai sobre o conto “Raul da Ferrugem Azul”, de Ana Maria Machado (2012). Metodologicamente, caracteriza-se como uma pesquisa com intervenção. O locus de sua realização foi uma escola pública do Município de Natal – RN (BRASIL), em uma turma de 5º ano do Ensino Fundamental. Na intervenção pedagógica, realizaram-se dois encontros para a leitura e discussão do conto de Machado (2012). As sessões foram estruturadas a partir da andaimagem (GRAVES; GRAVES, 1995), levando-se em consideração os momentos de pré-leitura, leitura e pós-leitura. Sua análise ancorou-se em princípios da Análise de Conteúdos (BARDIN, 2010), sendo abordadas as seguintes categorias: motivação à leitura, estímulo à discussão, incentivo à reflexão, relação texto-vida e da reflexão ao julgamento. Os resultados da análise revelam que a mediação pedagógica, construída com base em questionamentos, foi de suma importância para que os sujeitos pudessem agir ativamente nas sessões de leitura e construíssem relações entre a violência na ficção e o modo de agir dos espectadores na vida real, considerando as agressões presentes cotidianamente no ambiente escolar. Palavras-chave: Literatura; Bullying; Espectadores
THE MECHANISM OF PUBLIC-PRIVATE PARTNERSHIP IN THE DEVELOPMENT OF SINGLE-INDUSTRY TOWNS IN THE REGIONS OF RUSSIA
Authors: Lebedenko O. 
Published: January 2022

The article discusses the issues of choosing priorities in the development of single-industry towns. The conceptual framework and legal regulation are analyzed, the possibilities of using public-private partnership mechanisms in the development of single-industry towns in the regions of Russia are considered. It is shown that increasing the efficiency of PPP at the regional level, including in the development of single-industry towns, will solve a number of socio-economic problems. This is the development of social, transport, communal, and energy infrastructure. It is proved that among the main forms of investments, PPP is used in projects of reconstruction and modernization of water supply and sewerage systems, energy, transport.
In the course of the study, the dynamics of the development of single-industry towns in three categories was analyzed, the results of state regulation of their functioning were presented. The main characteristics of single-industry towns are given and the assessment of the level of socio-economic development of single-industry towns of the Central Chernozem region is made, as well as the prospects for development based on public-private partnership are determined, a roadmap for the implementation of the main measures is developed.
As conclusions, reasonable proposals have been made regarding the prospects of using PPP mechanisms for single-industry towns of the Central Asian Republic.
PERANCANGAN TEBAL PERKERASAN LENTUR DENGAN MENGGUNAKAN METODE MANUAL DESAIN PERKERASAN JALAN/NO.02/M/BM/2017
Authors: Azwanda.H Rizky , Lizar Lizar 
Published: January 2022

Jalan Simpang Ayam merupakan jalan yang menuju kesalah satu kampus Politeknik Negeri Bengkalis Jurusan Kemaritiman dan juga kesalah satu lokasi tempat wisata yang dikenal dengan sebutan Pantai Sesai, yang berada dipenghujung jalan. Untuk menuju kesana terdapat beberapa permasalahan, diantaranya jalan rusak, tergenang air di kala musim penghujan serta kendaraan yang melewati pun terasa kurang nyaman.melihat kondisi jalan tersebut mengalami kerusakan oleh karna itu perlu adanya perencanaan ulang perkerasan lentur (Flexible Pavement) pada Jalan Simpang Ayam untuk mempermudahkan akses masyarakat dalam berlalu lintas.Penelitian ini menggunakan Metode Manual Desain Perkerasan Jalan Revisi September 2017 Nomor 02/M/BM/2017 dan rencana anggaran biaya berdasarkan Analisa Harga Satuan Pekerjaan Tahun 2016.Berdasarkan hasil perhitungan tebal perkerasan yang didapat dari metode Manual Desain Perkerasan Jalan revisi September 2017 Nomor 02/M/BM/2017, dibutuhkan dana sebesar Rp 20.195.950,00(Duapuluh milyar seratus sembilan puluh lima juta sembilan ratus lima puluh ribu rupiah).
TINGKAT PENGETAHUAN DAN PERILAKU MASYARAKAT TERHADAP PENGGUNAAN ANTIBIOTIK DI BEBERAPA APOTEK DI KOTA TERNATE
Authors: Marsudi Ardiyanto 
Published: January 2022

ABSTRAKAntibiotik merupakan zat kimiawi yang dihasilkan oleh mikroorganisme yang mempunyai kemampuan untuk menghambat pertumbuhan atau membunuh mikroorganisme lainnya. Penggunaan antibiotik secara swamedikasi dipengaruhi oleh pengetahuan seseorang, sehingga apabila pengetahuan seseorang tidak tepat dapat menyebabkan kesalahan dalam penggunaan. Ketidaktepatan penggunaan antibiotik banyak ditemukan di masyarakat luas, hal ini dapat menjadi penyebab resiko buruk seperti resistensi antibiotik. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan antibiotik dan penggunaan antibiotik pada masyarakat di Kota Ternate. Penelitian ini merupakan penelitian deskriptif yang bersifat observasional terhadap 305 responden yang memenuhi kriteria inklusi. Hasil penelitian yang diperoleh yaitu tingkat pengetahuan antibiotik pada masyarakat di Kota Ternate yang termasuk kategori baik (18%), cukup (43%) dan kurang (39%); untuk tingkat perilaku penggunaan antibiotik pada masyarakat di Kota Ternate yang termasuk kategori baik (19%), cukup (52%) dan kurang (29%). Mayoritas tingkat pengetahuan dan perilaku terkait penggunaan antibiotik pada masyarakat di Kota Ternate termasuk kategori cukup. Kata kunci: Antibiotik, swamedikasi, pengetahuan, perilaku penggunaan
KAJIAN LITERATUR AKTIVITAS ANTIKANKER TANAMAN BUNGA MATAHARI (HELIANTHUS ANNUS L) TERHADAP BERBAGAI KULTUR SEL KANKER
Authors: Ulfa Ana Maria Ana 
Published: January 2022

Penyakit kanker merupakan penyakit yang sangat kompleks dan menduduki peringkat pertama di dunia. Bagian tanaman yang mempunyai efek sitotoksik pada kultur sel kanker yang sudah diteliti yaitu batang, daun, bunga dan biji. Kajian literatur ini bertujuan untuk mengetahui aktivitas sitotoksik terhadap kultur sel kanker, kandungan senyawa aktif yang berperan dan mekanisme aksi.Kajian literatur ini menggunakan metode naratif review dengan cara mengumpulkan data dari berbagai sumber dan pustaka dengan beberapa jurnal dan artikel ilmiah. Jurnal yang diperoleh sebanyak 20 jurnal yang sesuai dengan aktivitas antikanker pada tanaman bunga matahariHasil yang didapatkan diketahui bahwa tanaman bunga matahari mempunyai aktivitas sitotoksik pada berbagai kultur sel kanker berupa Sel A549, Caco -2, RD, limfosit B, Raji, A375, MDA –AMB 231, HCT 116, T98G, Hela dan Neuroblastoma. Kandungan senyawa aktif yang berperan berupa 5-pentildihidrofuran-2(3H)-satu, (Z)-metil 4-(isobutiriloksi) but-3-enoat, dan asam 2-fenilasetat, Flavonid, asam palimitat, asam linolenat, asam -Linoleat dan asam Stearidonic, Terpenoid, sesquiterpen dan steroid, asam palimitat, asam linolenat, asam -Linoleat dan asam Stearidonic, terpinene, terpinolene dan linalool alkaloid, glikosida. Mekanisme aksi pada tanaman ini menghambat apoptosis, proliferasi sel, transformasi sel, metastasis, viabilitas sel, mempengaruhi jalur apoptosis terhadap siklus sel pada fase G1, fase S, dan fase G2 / M.
Effect of Ownership Structures on Financial Performance of Listed Manufacturing Firms in Kenya
Authors: Nzau Stella Kavengi , Musa Grace 
Published: January 2022

Over the last decade, performance of listed manufacturing firms has been deteriorating with some companies almost collapsing. For instance, Mumias Sugar Company and Eveready have shown dismal financial performance. Prior studies have not addressed the effect of ownership structures on financial performance of manufacturing firms in Kenya. The main objective of the study was to determine the effect of ownership structures on financial performance of listed manufacturing firms in Kenya. Specifically, the study sought: to evaluate the effect of board shareholding on financial performance of listed manufacturing firms in Kenya, to explore the effect of foreign shareholding on financial performance of listed manufacturing firms in Kenya, to investigate the effect of institutional shareholding on financial performance of listed manufacturing firms in Kenya, to determine the effect of individual shareholding on financial performance of listed manufacturing firms in Kenya. This study was pegged on five theories; agency theory, stewardship theory, Stulz’s Integrated Theory, stakeholder’s theory and Resource based theory. This study was undertaken using a descriptive research design. The target population comprised of all seven listed manufacturing firms in Kenya that traded at NSE from 2010 to 2019. The study adopted a census method of data collection. This was made possible using secondary data sheet. Data analysis was undertaken using panel data regression and data analysis results were presented on tables and graphs. The findings revealed that the model linking ownership structures and firm performance was significant. Moreover, the results revealed that foreign shareholding was inconclusive on the effect it has to the financial performance of listed manufacturing firms. Institutional shareholding has negative significant effect on the returns on assets while individual shareholding had a positive and significant effect on firm performance. This study recommended dispersed ownership as it improved financial performance of the manufacturing firms.
The References of Using Deixis in the Novel The Kite Runner
Authors: Sri Haryanti Ika Novia , Wahyuni Wahyuni , Panggabean Waladdin 
Published: January 2022

There are two objectives of this research; to identify the types of deixis used in the utterances in the novel The Kite Runner; and to explain the references of using deixis found in the novel. The method used in this research is the qualitative descriptive method because the data were analyzed in the form of words and utterances. The theory used in this research is the Deixis theory by Stephen C. Levinson’s, also supported by the theory of references by Yule. The result of this research shows that there are five types of deixis found in the novel The Kite Runner by Khaled Hosseini, those are person deixis, place deixis, time deixis, discourse deixis, and social deixis. The references of using deixis found anaphora and cataphora. Based on the data deixis that has been found and analyzed by the researcher in this research, person deixis is more dominant used in the novel, and for the use of references, anaphora reference is more dominant used than cataphora reference in the novel The Kite Runner.
ANALISIS PERBANDINGAN KINERJA KEUANGAN PADA PT WIJAYA KARYA, TBK DAN PT WASKITA KARYA, TBK YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Lie Darwin , Inrawan Ady , Astuti Astuti , Ardi Reza Dhea 
Published: January 2022

Tujuan dari penelitian ini adalah untuk mengetahui: 1. Gambaran kinerja keuangan PT Wijaya Karya, Tbk dan PT Waskita Karya, Tbk. 2. Faktor-faktor yang menyebabkan perbedaan kinerja keuangan PT Wijaya Karya, Tbk dan PT Waskita Karya, Tbk. Desain penelitian ini menggunakan penelitian kepustakaan. Penelitian ini dilakukan dengan menggunakan teknik analisis deskriptif kualitatif, teknik analisis komparatif dan teknik analisis induktif. Hasil penelitian ini dapat disimpulkan sebagai berikut: 1. Kinerja keuangan PT Wijaya Karya, Tbk periode 2015-2019 pada rasio pertumbuhan penjualan dan struktur aset menciptakan kinerja keuangan yang kurang baik sedangkan pada rasio struktur modal dan profitabilitas mampu menciptakan kinerja keuangan yang baik. 2. Kinerja keuangan PT Waskita Karya, Tbk periode 2015-2019 pada rasio pertumbuhan penjualan dan profitabilitas menciptakan kinerja keuangan yang kurang baik sedangkan pada rasio struktur aset dan struktur modal kinerja keuangan yang baik. 3. Kinerja keuangan PT Waskita Karya, Tbk lebih baik dari pada PT Wijaya Karya, Tbk dikarenakan pada rasio pertumbuhan penjualan, struktur aset dan struktur modal PT Waskita Karya, Tbk mampu memperoleh kinerja keuangan yang baik. 4. Faktor-faktor yang menyebabkan perbedaan kinerja keuangan antara dua perusahaan adalah menurunnya penjualan, meningkatnya aset tetap, meningkatnya total aset, meningkatnya kewajiban jangka panjang, menurunnya ekuitas dan meningkatnya laba bersih.Kata Kunci: Pertumbuhan penjualan, Struktur Aset, Struktur Modal, Profitabilitas, Kinerja Keuangan
CULTURAL INTELLIGENT; POSSIBILITIES TO CREATE IT IN INTERCULTURAL COMMUNICATION AND LINGUODIDACTICS
Authors: Шипелевич Л. 
Published: January 2022

В статье рассматриваются особенности культурного интеллекта и возможности формирования его в межкультурной коммуникации и лингводидактике на базе исследований психологов.
This article about cultural intelligent and possibilities to form it in intercultural communication and in didactic of foreign languages.
Media text as a space for the formation of linguistic norms in intercultural
Authors: Бертякова А.Н. 
Published: January 2022

В статье аргументируется необходимость декодирования в медиа-пространстве как локусе установления контактов, взаимосвязей между отдельными представителями различных культур, а также группами, сообществами, принадлежащими к различным культурам, языковых маркеров смысловых доминант, определяющих в речевом взаимодействии носителей языка формирование новых языковых норм.
The article argues the need for decoding in the media space as a space for establishing contacts, relationships between individual representatives of different cultures, as well as groups, communities belonging to different cultures, linguistic markers of semantic dominants that determine the formation of new linguistic norms in the speech interaction of native speakers.
INTENSIVE ONLINE COURSE FOR FOREIGN APPLICANTS OF THE FACULTY OF PHILOLOGY
Authors: Татаринова Н.В. , Халеева О.Н. 
Published: January 2022

Статья посвящена актуальной проблеме создания учебных материалов для обучения иностранцев русскому языку в дистанционном формате. В статье рассмотрен опыт создания онлайн-курса для иностранных абитуриентов, владеющих русским языком в объеме первого сертификационного уровня (В1) и готовящихся к поступлению на филологические факультеты.
The article is devoted to the actual problem of creating educational materials for teaching foreigners the Russian language in a distance format. The article discusses the experience of creating an online course for foreign applicants who speak Russian in the volume of the first certification level (B1) and are preparing for admission to philological faculties.
COMPREHENSIVE EXAM IN RUSSIAN LANGUAGE, HISTORY OF RUSSIA AND BASIS OF LEGISLATION OF THE RUSSIAN FEDERATION: GOALS, EXPERIENCE, PROSPECTS
Authors: Шиманюк Е.Г. , Тихонова Е.В. , Тимофеева Д.С. 
Published: January 2022

В статье обобщается опыт России по организации тестирования для получения вида на жительства, разрешения на временное проживание и патента. Авторы статьи анализируют вступивший в силу летом 2021 г. новый порядок проведения экзамена по русскому языку как иностранному, истории России и основам законодательства Российской Федерации. Статья предлагает обзор основных отличительных черт нового и старого форматов тестирования, подчеркивает достоинства и указывает на некоторые недостатки в порядке проведения комплексного экзамена. Кроме того, в статье даны рекомендации по усовершенствованию процедуры проведения комплексного экзамена.
The article summarizes the experience of Russia in receiving testing for obtaining a residence permit, temporary residence permit and a patent. The authors of the article analyze the new procedure for conducting the exam in Russian as a foreign language, the history of Russia and the basics of the legislation of the Russian Federation, which came into force in the summer of 2021. The article provides an overview of the main distinguishing features of the new and old testing format, emphasizes the advantages and points out some of the shortcomings in the procedure for conducting a comprehensive exam. In addition, the article provides recommendations for improving the procedure for conducting a comprehensive exam.
Phonetic speech correction course for Chinese: what should it be? (from work experience at the Shenzhen MSU-BIT University)
Authors: Прохватилова О.А. 
Published: January 2022

Статья посвящена рассмотрению содержательных особенностей корректировочного курса фонетики РКИ для носителей китайского языка. На основе опыта преподавания в Совместном университете МГУ-ППИ и с учетом имеющихся в специальной литературе представлений о фонетико-фонологической системе китайского языка и китайском акценте формулируется ведущий принцип построения корректировочного курса фонетики, сочетающий ориентацию на китайскую артикуляционную базу и учет специфики фонетико-фонологической системы китайского языка. Предлагается описание содержательной структуры корректировочного курса для китайских студентов, которая включает четыре компонента: работу над проблемами в освоении консонантной системы русского языка, совершенствование навыков произношения гласных звуков в безударной позиции, отработку ритмико-интонационного членения речевого потока русской звучащей речи, знакомство со стилистическими особенностями русской звучащей речи.
The article is devoted to the consideration of the content features of the correction course of the phonetics of the RCT for native speakers of the Chinese language. Based on the experience of teaching at the Joint University of MSU-PPI and taking into account the ideas available in the special literature about the phonetic-phonological system of the Chinese language and the Chinese accent, the leading principle of constructing a correction course of phonetics is formulated, combining orientation to the Chinese articulation base and taking into account the specifics of the phonetic-phonological system of the Chinese language. Russian Russian is a description of the content structure of the correction course for Chinese students, which includes four components: work on problems in mastering the consonant system of the Russian language, improving the skills of pronunciation of vowel sounds in an unstressed position, working out the rhythmic-intonation division of the speech flow of Russian sounding speech, familiarity with the stylistic features of Russian sounding speech.
ENGLISH LOANS IN CONTEMPORARY RUSSIAN BY YULIYA BALDWIN. ROUTLEDGE. TAYLOR AND FRANCIS GROUP. LONDON AND NEW YOURK, 2021. – 314 pp.
Authors: Барклай И.Е. 
Published: January 2022

Книга американского автора Юлии Болдуин «Английские заимствования в современном русском языке» включает в себя более2 тысяч англицизмов и является ценным источником по изучению иностранных заимствований в русском языке. Эта книга рекомендуется всем, кто стремится понять тесные связи между нашими языками в бизнесе, политике, науке и культуре.
English Loans in Contemporary Russian by Yuliya Baldwin presents over 2,000 English borrowings in the Russian lexicon, adding an invaluable addition of loanwords to contemporary Russian. This work will be of great value to those in business, politics, science, and culture understanding the link between our languages.
SOPA DE WUHAN. PENSAMIENTO CONTEMPORÁNEO EN TIEMPOS DE PANDEMIAS (2020)
Authors: Taboada Hernández Marco Polo 
Published: January 2022

Reseña del libro SOPA DE WUHAN. PENSAMIENTO CONTEMPORÁNEO EN TIEMPOS DE PANDEMIAS, de los atuores Giorgio Agamben, Slavoj Žižek, Jean Luc Nancy, Franco “Bifo” Berardi, Santiago Lopez Petit, Judith Butler, Alain Badiou, David Harvey, Byung- Chul Han, Raul Zibechi, Maria Galindo, Markus Gabriel, Gus- tavo Yanez Gonzalez, Patricia Manrique y Paul B. Preciado. ASPO, 2020.