bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of pharmacy technician job satisfaction and duties in ambulatory care pharmacy settings: A mixed-methods analysis
Authors: Schlosser Elizabeth G , Rennekamp Tara , Bald Elizabeth , Jean Stephanie , Raber Hanna , Bato Agathea , Llambi Leandro , Hincapie Ana L 
Published: October 2022

AbstractPurposeExpansion of pharmacy services into ambulatory care has prompted the integration of pharmacy technicians into this setting. Many models exist for technician practice in ambulatory care, and job satisfaction in these settings needs evaluation. This study assessed the job satisfaction of ambulatory care pharmacy technicians, obtained a deeper understanding of their varied roles, and examined commitment to the pharmacy technician career and their employing organization.MethodsThis study used a mixed-methods sequential explanatory design of quantitative followed by qualitative data analysis. The phases included a validated questionnaire on job satisfaction and semistructured interviews using a modified guide and findings from the quantitative data. Descriptive statistics and constant comparative analysis were used to analyze quantitative and qualitative data, and data were integrated in the discussion.ResultsThe questionnaire was sent to 125 potential participants at 11 organizations in 8 unique states. Seventy-four technicians participated in the quantitative phase. Seventeen of these were interviewed in the qualitative phase. Interviewees represented 7 different institutions in 6 states in the Southeast, Midwest, and Western regions of the US. Both phases indicated that respondents felt a strong commitment to their organization, with 60% of respondents indicating this on the questionnaire. Reasons for this commitment were further elucidated in the qualitative phase, which indicated high satisfaction with technician autonomy, work schedules, and ability to provide important services to patients. It was also found in both phases that technician duties varied greatly among organizations, although most technicians were involved in facilitating medication access.ConclusionAmbulatory care pharmacy technicians are highly satisfied with their positions and careers. Although technician roles vary within ambulatory care settings, the majority involve facilitating medication access in various ways. As these positions become more prevalent in pharmacy practice, it will be important to continue to capitalize on satisfiers and mitigate dissatisfiers to advance the profession and ultimately provide optimal patient care.
Selective Analysis of Progesterone in Cosmetic Samples Based on Molecularly Imprinted Solid-Phase Extraction and High-Performance Liquid Chromatography
Authors: Cui Xia , Wang Qun , Guo Miao , Yang Ke , Yu Liangwei , Luo Zhimin , Chang Chun , Fu Qiang 
Published: October 2022

Abstract
The illegal addition of progesterone to cosmetics could cause serious adverse reactions and pose a serious threat to human health. In this work, a simple, fast and sensitive method was developed by combining molecularly imprinted solid-phase extraction and high-performance liquid chromatography (MISPE–HPLC) for the selective determination of progesterone in cosmetics. Chitosan-modified silica is used as the carrier to provide binding sites for the effective conjugation of the target. The obtained molecularly imprinted polymers exhibited excellent adsorption capacity (36.2 mg·g−1), good selectivity and fast mass transfer rate for progesterone. Meanwhile, the prepared MISPE column could eliminate the interference of co-existing substances. Combined MISPE with HPLC, a selective and effective method for detecting progesterone in different cosmetics was achieved. Under the optimum conditions, the established MISPE–HPLC method was successfully used for the detection of progesterone in real samples. The linear range of this method was 1 to 200 μg·mL−1 with a limit of detection of 0.016 μg·mL−1. Therefore, this method could be used for the selective and effective detection of progesterone in different cosmetic samples with complex substrates. We provided an alternative method for the detection of illegal additions in cosmetics.
BRACS: A Dataset for BReAst Carcinoma Subtyping in H&E Histology Images
Authors: Brancati Nadia , Anniciello Anna Maria , Pati Pushpak , Riccio Daniel , Scognamiglio Giosuè , Jaume Guillaume , De Pietro Giuseppe , Di Bonito Maurizio , Foncubierta Antonio , Botti Gerardo , Gabrani Maria , Feroce Florinda , Frucci Maria 
Published: October 2022

Abstract
Breast cancer is the most commonly diagnosed cancer and registers the highest number of deaths for women. Advances in diagnostic activities combined with large-scale screening policies have significantly lowered the mortality rates for breast cancer patients. However, the manual inspection of tissue slides by pathologists is cumbersome, time-consuming and is subject to significant inter- and intra-observer variability. Recently, the advent of whole-slide scanning systems has empowered the rapid digitization of pathology slides and enabled the development of Artificial Intelligence (AI)-assisted digital workflows. However, AI techniques, especially Deep Learning, require a large amount of high-quality annotated data to learn from. Constructing such task-specific datasets poses several challenges, such as data-acquisition level constraints, time-consuming and expensive annotations and anonymization of patient information. In this paper, we introduce the BReAst Carcinoma Subtyping (BRACS) dataset, a large cohort of annotated Hematoxylin and Eosin (H&E)-stained images to advance AI development in the automatic characterization of breast lesions. BRACS contains 547 Whole-Slide Images (WSIs) and 4539 Regions Of Interest (ROIs) extracted from the WSIs. Each WSI and respective ROIs are annotated by the consensus of three board-certified pathologists into different lesion categories. Specifically, BRACS includes three lesion types, i.e., benign, malignant and atypical, which are further subtyped into seven categories. It is, to the best of our knowledge, the largest annotated dataset for breast cancer subtyping both at WSI and ROI levels. Furthermore, by including the understudied atypical lesions, BRACS offers a unique opportunity for leveraging AI to better understand their characteristics. We encourage AI practitioners to develop and evaluate novel algorithms on the BRACS dataset to further breast cancer diagnosis and patient care.
Database URL: https://www.bracs.icar.cnr.it/
Finerenone efficacy in patients with chronic kidney disease, type 2 diabetes and atherosclerotic cardiovascular disease
Authors: Filippatos Gerasimos , Anker Stefan D , Pitt Bertram , McGuire Darren K , Rossing Peter , Ruilope Luis M , Butler Javed , Jankowska Ewa A , Michos Erin D , Farmakis Dimitrios , Farjat Alfredo E , Kolkhof Peter , Scalise Andrea , Joseph Amer , Bakris George L , Agarwal Rajiv 
Published: October 2022

Abstract

Aims
Finerenone, a selective, non-steroidal mineralocorticoid receptor antagonist, improves cardiovascular (CV) and kidney outcomes in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). This subgroup analysis of FIDELITY, a pre-specified, pooled, individual patient-data analysis of FIDELIO-DKD (NCT02540993) and FIGARO-DKD (NCT02545049), compared finerenone vs. placebo in patients with and without baseline history of atherosclerotic CV disease (ASCVD).

Methods and results
Outcomes included a composite CV outcome [CV death, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for heart failure (HHF)]; CV death or HHF; a composite kidney outcome (kidney failure, sustained estimated glomerular filtration rate decrease ≥57%, or kidney-related death); all-cause mortality; and safety by baseline history of ASCVD.
Of 13 026 patients, 5935 (45.6%) had a history of ASCVD. The incidence of the composite CV outcome, CV death or HHF, and all-cause mortality was higher in patients with ASCVD vs. those without, with no difference between groups in the composite kidney outcome. Finerenone consistently reduced outcomes vs. placebo in patients with and without ASCVD (P-interaction for the composite CV outcome, CV death or HHF, the composite kidney outcome, and all-cause mortality 0.38, 0.68, 0.33, and 0.38, respectively). Investigator-reported treatment-emergent adverse events were consistent between treatment arms across ASCVD subgroups.

Conclusion
Finerenone reduced the risk of CV and kidney outcomes consistently across the spectrum of CKD in patients with T2D, irrespective of prevalent ASCVD.
Age-Related Microaggressions: A Descriptive Study
Authors: Gietzen Luke J , Lewis Hannah , Buchanan Jeffrey A 
Published: October 2022

Abstract

Background and Objectives
The aim of this study was to expand the literature on ageism by exploring the phenomenon of age-related microaggressions.

Research Design and Methods
Fifty-one participants completed an online survey asking a series of questions about their experiences with microaggressions related to their age. Responses were summarized using a thematic analysis.

Results
Participants reported frequently experiencing age-related microaggressions, particularly microinsults. Microaggressions occurred in a variety of settings, often by individuals unfamiliar to the older adult. Although most participants reported having negative emotional reactions to microaggression and believing these acts are intentional, in most cases, perpetrators are not confronted.

Discussion and Implications
Our hope is this descriptive study will serve as a foundational framework for conducting future exploration on age-related microaggressions and their effects on older adults and society at large.
Seismic ambient noise auto-correlation imaging in a CO2 storage area
Authors: Zhao Ce , Zheng Yikang , Wang Yibo , Zhao Liang 
Published: October 2022

Abstract
Carbon capture and storage is an effective technique for achieving ‘carbon neutrality’. Seismology plays an important role in detecting and monitoring whether CO2 has been safely sealed. However, active seismic surveys are usually incapable of continuous observations. We can extract the body wave and image the subsurface interface directly and continuously via single sensor ambient noise auto-correlation. However, because of the weak body wave in the ambient noise and the multiples in the imaging results, it is challenging to improve the imaging resolution. This study provides a reference for the development of the ambient noise (phase) auto-correlation imaging method for future use in carbon storage areas. In this study, we performed numerical experiments to show that the phase auto-correlation method is better than the auto-correlation in terms of weakening artefacts and detecting subsurface thin CO2 layers. Then, we applied the phase auto-correlation method in the Ketzin (Germany) CO2 storage area. Using 223 body-wave dominated noise panels automatically selected from totally 4680 panels, we imaged two primary interfaces, which are consistent with the common midpoint stacking results obtained using active seismic surveys. We applied a multiple removal approach to the imaging results and obtained high precision results. Then, we applied the proposed workflow to three passive seismic survey lines north of the CO2 injection well. The results of the three passive surveys demonstrate the workflow is robust.
Zeta revisited: A rejoinder
Authors: Hoover David L 
Published: October 2022

Abstract
Zeta is a relatively recently developed tool for authorship attribution and computational stylistics (Craig and Kinney, 2009, Shakespeare, Computers, and the Mystery of Authorship. Cambridge: Cambridge University Press). In ‘The Interpretation of Zeta Test Results’ (2019), Perves Rizvi raised several objections to the method. I responded to and rejected those objections in ‘Zeta Revisited’ (Hoover, 2021a, Zeta revisited. Digital Scholarship in the Humanities, 1–20). Rizvi has renewed two of his main objections in a critique of my response in his ‘The Interpretation of Zeta Test Results: A Supplement’ (2022). First, he reiterates and expands his argument that the separation of base and counter segments in a Zeta analysis is a mechanical consequence of Zeta, rather than a significant and meaningful finding. Second, he again rejects the use of the bisector line to attribute texts in a Zeta analysis as unsound and adds new arguments that it leads to invalid attributions. This rejoinder provides further evidence and argument that both of Rizvi’s claims must be rejected.
Orientation effects on cool gas absorption from gravitational-arc tomography of a z = 0.77 disc galaxy
Authors: Fernandez-Figueroa A , Lopez S , Tejos N , Berg T A M , Ledoux C , Noterdaeme P , Afruni A , Barrientos L F , Gonzalez-Lopez J , Hamel M , Johnston E J , Katsianis A , Sharon K , Solimano M 
Published: October 2022

ABSTRACT
We use spatially resolved spectroscopy of a distant giant gravitational arc to test orientation effects on Mg ii absorption equivalent width (EW) and covering fraction (〈κ〉) in the circumgalactic medium of a foreground star-forming galaxy (G1) at z ∼ 0.77. Forty-two spatially-binned arc positions uniformly sample impact parameters (D) to G1 between 10 and 30 kpc and azimuthal angles α between 30° and 90° (minor axis). We find an EW-D anticorrelation, akin to that observed statistically in quasar absorber studies, and an apparent correlation of both EW and 〈κ〉 with α, revealing a non-isotropic gas distribution. In line with our previous results on Mg ii kinematics suggesting the presence of outflows in G1, at minimum a simple 3D static double-cone model (to represent the trace of bipolar outflows) is required to recreate the EW spatial distribution. The D and α values probed by the arc cannot confirm the presence of a disc, but the data highly disfavour a disc alone. Our results support the interpretation that the EW-α correlation observed statistically using other extant probes is partly shaped by bipolar metal-rich winds.
Gravitational-wave inference for eccentric binaries: the argument of periapsis
Authors: Clarke Teagan A , Romero-Shaw Isobel M , Lasky Paul D , Thrane Eric 
Published: October 2022

ABSTRACT
Gravitational waves from binary black hole mergers have allowed us to directly observe stellar-mass black hole binaries for the first time and therefore explore their formation channels. One of the ways to infer how a binary system is assembled is by measuring the system’s orbital eccentricity. Current methods of parameter estimation do not include all physical effects of eccentric systems, such as spin-induced precession, higher order modes, and the initial argument of periapsis: an angle describing the orientation of the orbital ellipse. We explore how varying the argument of periapsis changes gravitational waveforms and study its effect on the inference of astrophysical parameters. We use the eccentric spin-aligned waveforms TEOBResumS and SEOBNRE to measure the change in the waveforms as the argument of periapsis is changed. We find that the argument of periapsis could already be impacting analyses performed with TEOBResumS. However, it is likely to be well resolvable in the foreseeable future only for the loudest events observed by LIGO–Virgo–KAGRA. The systematic error in previous, low-eccentricity analyses that have not considered the argument of periapsis is likely to be small.
Evaluating possible spectroscopic variation of Bennu’s sampling site
Authors: Praet A , Poggiali G , Barucci M A , Clark B E , Zou X-D , Simon A A , Kaplan H H , Li J-Y , Alcaria C 
Published: October 2022

ABSTRACT
The OSIRIS-REx spacecraft completed the first part of the primary objective by successfully sampling the surface of asteroid (101955) Bennu and storing the acquired sample in the re-entry capsule. The sampling ‘Touch-And-Go’ (TAG) maneuver was performed nominally at the primary sampling site, Nightingale, in Bennu’s Northern hemisphere. As a consequence of the TAG, material at the sampling site was mobilized and the morphology of the area was altered. This event offered a unique opportunity to investigate, in detail, the subsurface of asteroid Bennu giving access to fine grained and less altered material from Nightingale crater. We performed a detailed study on the infrared spectrum in the Nightingale region to search for modification resulting from the sampling event by analysing different features: slope, the H2O–OH− related absorption band in the $2.7\ \mu {\rm m}$ region, and other possible features. Our results show that, despite visible alteration of the TAG location detected by cameras, no strong variations are observed in the near-infrared bands and their quantitative evaluation is not possible beyond all the instrumental effects, although some changes may have occurred. We confirm that the infrared spectrum of the sampling site becomes redder with respect to the pre-TAG observations, conceivably due to fine material mobilization and exposure of less altered material, as confirmed by decreased spectral convexity. We identify possible modification of hydrated band at $2.7\ \mu {\rm m}$ but with some concerns due to data quality. However, our results place new constraints on the nature of Bennu’s subsurface material and the sample collected by OSIRIS-REx.
Dark particle mass effects on neutron star properties from a short-range correlated hadronic model
Authors: Dutra M , Lenzi C H , Lourenço O 
Published: October 2022

ABSTRACT
In this work we study a relativistic mean-field (RMF) hadronic model, with nucleonic short-range correlations (SRC) included, coupled to dark matter (DM) through the Higgs boson. We study different parametrizations of this model by running the dark particle Fermi momentum, and its mass in the range of 50GeV ≤ Mχ ≤ 500GeV, compatible with experimental spin-independent scattering cross-sections. By using this RMF-SRC-DM model, we calculate some neutron star quantities, namely, mass–radius profiles, dimensionless tidal deformabilities, and crustal properties. Our findings show that is possible to construct RMF-SRC-DM parametrizations in agreement with constraints provided by LIGO and Virgo collaboration (LVC) on the GW170817 event, and recent observational data from the NICER mission. Furthermore, we show that the increase of Mχ favors the model to attain data from LVC regarding the tidal deformabilities. Higher values of Mχ also induce a reduction of the neutron star crust (mass and thickness), and cause a decrease of the crustal fraction of the moment of inertia (Icrust/I). Nevertheless, we show that some RMF-SRC-DM parametrizations still exhibit $I_{{\rm crust}}/I\gt 7{{\ \rm per\ cent}}$, a condition that explains the glitch activity in rotation-powered pulsars such as the Vela one. Therefore, dark matter content can also be used for describing such a phenomenon.
Searching for outbursts in the ground-based photometry of 67P/Churyumov–Gerasimenko
Authors: Gardener Daniel , Snodgrass Colin , Ligier Nicolas 
Published: October 2022

ABSTRACT
67P/Churyumov–Gerasimenko is a Jupiter-family comet that was the target of the Rosetta mission, the first mission to successfully orbit and land a probe on a comet. This mission was accompanied by a large ground-based observing campaign. We have developed a pipeline to calibrate and measure photometry of comet 67P during its 2016 perihelion passage, making use of all visible wavelength broad-band imaging collected across a wide range of facilities. The pipeline calibrates the brightness of the comet to a common photometric system (Pan-STARRS 1) using background stars within the field allowing for compilation and comparison of multiple data sets. Results follow the predictions based on previous apparitions: 67P shows no obvious change in activity levels from orbit-to-orbit and coma colours remain constant throughout the apparition. We detected an outburst on 2015 August 22 of ∼0.14 mag. The brightness and estimated mass of this outburst puts it in line with the outbursts directly observed on the nucleus by Rosetta. An in situ outburst was observed at the same time as the one seen from the ground; however, linking these two events directly remains challenging.
A new look at the infrared properties of z ∼ 5 galaxies
Authors: Sommovigo L , Ferrara A , Carniani S , Pallottini A , Dayal P , Pizzati E , Ginolfi M , Markov V , Faisst A 
Published: October 2022

ABSTRACT
Recent Atacama Large Millimeter Array large surveys unveiled the presence of significant dust continuum emission in star-forming galaxies at z &gt; 4. Unfortunately, such large programs – i.e. ALPINE (z ∼ 5) and REBELS (z ∼ 7) – only provide us with a single far-infrared (FIR) continuum data point for their individual targets. Therefore, high-z galaxies FIR spectral energy densities (SEDs) remain mostly unconstrained, hinging on an assumption for their dust temperature (Td) in the SED fitting procedure. This introduces uncertainties in the inferred dust masses (Md), infrared luminosities (LIR), and obscured star formation rate (SFR) fraction at z &gt; 4. In this work, we use a method that allows us to constrain Td with a single-band measurement by combining the 158 $\mu$m continuum information with the overlying [C ii emission line. We analyse the 21 [C ii and FIR continuum-detected z ∼ 5 galaxies in ALPINE, finding a range of Td = 25–60 K and Md = 0.6–25.1 × 107 M⊙. Given the measured stellar masses of ALPINE galaxies, the inferred dust yields are around Md/M⋆ = (0.2–8) × 10−3, consistent with theoretical dust-production constraints. We find that eight out of the 21 ALPINE galaxies have LIR ≥ 1012 L⊙, comparable to ultraluminous IR galaxies (ULIRGs). Relying on ultraviolet-to-optical SED fitting, the SFR was underestimated by up to two orders of magnitude in four of these eight ULIRGs-like galaxies. We conclude that these four peculiar sources should be characterized by a two-phase interstellar medium structure with ‘spatially segregated’ FIR and ultraviolet emitting regions.