bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between mean platelet volume and poor outcome in patients with COVID-19: Systematic review, meta-analysis, and meta-regression
Authors: Zein Ahmad Fariz Malvi Zamzam , Sulistiyana Catur Setiya , Raffaelo Wilson Matthew , Pranata Raymond 
Published: August 2022

Introduction: This study aims to assess the association between mean platelet volume (MPV) and poor outcome in patients with COVID-19. Methods: We performed a comprehensive literature search using the PubMed, Embase and Scopus databases with keywords “2019-nCoV” OR “SARS-CoV-2” OR “COVID-19” AND “mean platelet volume” OR “MPV” on 8 July 2021. The primary outcome was composite poor outcome, defined as severe COVID-19 or mortality. The pooled effect estimate was reported as mean differences in terms of MPV between the group with and without outcome. Results: There were 17 studies which consist of 4549 patients with COVID-19 were included in this study. The incidence of poor outcome was 25% (20%–30%). Mean MPV was found to be higher in the poor outcome group in compare to no poor outcome group (10.3 ± 1.9 fL vs 9.9 ± 1.7 fL). The mean MPV difference between both group was 0.47 fL [95% CI 0.27, 0.67], p < 0.001; I2: 62.91%, p < 0.001). In the sub-group analysis, patients with severe COVID-19 had higher MPV (mean difference 0.54 fL [95% CI 0.28, 0.80], p < 0.001; I2: 54.84%, p = 0.014). Furthermore, MPV was also higher in the mortality group (mean difference 0.54 fL [95% CI 0.29, 0.80], p = 0.020; I2: 71.11%, p = 0.004). Meta-regression analysis showed that the association between MPV and poor outcome was not affected by age ( p = 0.789), gender ( p = 0.167), platelets ( p = 0.056), white blood cells ( p = 0.639), and lymphocytes ( p = 0.733). Conclusion: This meta-analysis indicated that increased MPV was associated with severity and mortality in patients with COVID-19. Further research is needed to determine the optimum cut-off point.
Minerals of the arctite supergroup from the Bellerberg volcano xenoliths, Germany
Authors: Juroszek Rafał , Krüger Biljana , Marciniak-Maliszewska Beata , Ternes Bernd 
Published: August 2022

AbstractThe recently defined arctite supergroup contains nine mineral members defined as hexagonal intercalated antiperovskites, most of which have been found in pyrometamorphic rocks of the Hatrurim Complex, Israel. Three members of this supergroup: nabimusaite, gazeevite and zadovite, were identified for the first time in altered carbonate–silicate xenoliths from the Caspar and Scherer quarries, Bellerberg volcano in Germany. Present work focuses on the chemical, structural and spectroscopic investigation of these minerals and their correlation with holotype counterparts. The apparent differences are mainly related to the chemical composition, types of substitution in the tetrahedral and antiperovskite layers within the crystal structure, and position of bands in the Raman spectra. In the Bellerberg volcano xenoliths, the crystallisation of nabimusaite and gazeevite is caused by high-temperature alteration of early mineral associations (clinker-like phases) and their reaction with melt or gas generated by volcanic activity. In turn, the formation of zadovite is related to the Ba-rich silicate melt that filled the intergranular space between the rock-forming minerals.
Iron-bearing to iron-rich tourmalines from granitic pegmatites of the Murzinka pluton, Central Urals, Russia
Authors: Gvozdenko Tatiana A. , Baksheev Ivan A. , Khanin Dmitry A. , Voronin Mikhail V. , Chervyakovskaya Maria V. , Smolensky Vadim V. 
Published: August 2022

AbstractBlack tourmalines from seven granitic pegmatites (Golodnaya, Kazennitsa, Mokrusha, Kopi Mora, Zheltyye Yamy, Buzheninov Bor and Ministerskaya) related to the Murzinka pluton, Central Urals, Russia have been investigated using electron microprobe analysis, LA-ICP-MS, Raman and Mössbauer spectroscopy. Pegmatites are hosted by serpentinites and gneisses and are classified as schorl, oxy-schorl, fluor-schorl, dravite, oxy-dravite, foitite, oxy-foitite and darrellhenryite. The possible compositional evolution of tourmalines from the Ural pegmatites is as follows: Mg-rich dravite through to Fe-rich schorl, foitite and oxy-foitite to Fe- and Mn-rich darrellhenryite. The major substitutions in the tourmalines are: (1) Fe2+ ↔ Mg; (2) Al + WO2– ↔ Fe2+ + WOH–; (3) X-site vacancy + Al ↔ Na + Fe2+; (4) Al + WO2– ↔ Mg + WOH–; (5) X-site vacancy + Al ↔ Na + Mg; and (6) Fe ↔ Mn. Statical processing of the trace- and major-element composition distinguished three tourmaline groups: (1) trace Co, Ni, Pb, and major Ca and Mg; (2) uni-, di- and trivalent traces (Li, Zn, Ga) and di- and trivalent majors (Al, Mn); (3) U, Th, Hf, Ta, Nb, Y, In, and Sn which correspond to tri-, tetra-, and pentavalent high-field-strength elements. Mössbauer data shows the Fe3+/Fe2+ ratios in tourmalines from pegmatites hosted by gneisses (0.05–0.18) and serpentinites (0.28–0.65), indicates different oxidising environments. Raman data are consistent with the composition of the tourmalines.
Loss of α4A- and β1-tubulins leads to severe platelet spherocytosis and strongly impairs hemostasis in mice
Authors: Kimmerlin Quentin , Moog Sylvie , Yakusheva Alexandra , Ziessel Catherine , Eckly Anita , Freund Monique , Závodszky Gábor , Knapp Yannick , Mangin Pierre , Lanza François 
Published: August 2022

Abstract
Native circulating blood platelets present with a discoid flat morphology maintained by a submembranous peripheral ring of microtubules, named marginal band. The functional importance of this particular shape is still debated, but it was initially hypothesized to facilitate platelet interaction with the injured vessel wall and to contribute to hemostasis. The importance of the platelet discoid morphology has since been questioned on the absence of clear bleeding tendency in mice lacking the platelet-specific β1-tubulin isotype, which exhibits platelets with a thinner marginal band and an ovoid shape. Here, we generated a mouse model inactivated for β1-tubulin and α4A-tubulin, an α-tubulin isotype strongly enriched in platelets. These mice present with fully spherical platelets completely devoid of a marginal band. In contrast to the single knockouts, the double deletion resulted in a severe bleeding defect in a tail-clipping assay, which was not corrected by increasing the platelet count to normal values by the thrombopoietin-analog romiplostim. In vivo, thrombus formation was almost abolished in a ferric chloride–injury model, with only a thin layer of loosely packed platelets, and mice were protected against death in a model of thromboembolism. In vitro, platelets adhered less efficiently and formed smaller-sized and loosely assembled aggregates when perfused over von Willebrand factor and collagen matrices. In conclusion, this study shows that blood platelets require 2 unique α- and β-tubulin isotypes to acquire their characteristic discoid morphology. Lack of these 2 isotypes has a deleterious effect on flow-dependent aggregate formation and stability, leading to a severe bleeding disorder.
Association of respiratory symptoms and lung function with occupation in the multinational Burden of Obstructive Lung Disease (BOLD) study
Authors: Ratanachina Jate , Amaral Andre F.S. , De Matteis Sara , Lawin Herve , Mortimer Kevin , Obaseki Daniel O. , Harrabi Imed , Denguezli Meriam , Wouters Emiel F.M. , Janson Christer , Nielsen Rune , Gulsvik Amund , Cherkaski Hamid Hacene , Mejza Filip , Mahesh Padukudru Anand , Elsony Asma , Ahmed Rana , Tan Wan , Loh Li Cher , Rashid Abdul , Studnicka Michael , Nafees Asaad A. , Seemungal Terence , Aquart-Stewart Althea , Al Ghobain Mohammed , Zheng Jinping , Juvekar Sanjay , Salvi Sundeep , Jogi Rain , Mannino David , Gislason Thorarinn , Buist A. Sonia , Cullinan Paul , Burney Peter 
Published: August 2022

BackgroundChronic obstructive pulmonary disease has been associated with exposures in the workplace. We aimed to assess the association of respiratory symptoms and lung function with occupation in the Burden of Obstructive Lung Disease study.MethodsWe analysed cross-sectional data from 28 823 adults (≥40 years) in 34 countries. We considered 11 occupations and grouped them by likelihood of exposure to organic dusts, inorganic dusts and fumes. The association of chronic cough, chronic phlegm, wheeze, dyspnoea, forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1)/FVC with occupation was assessed, per study site, using multivariable regression. These estimates were then meta-analysed. Sensitivity analyses explored differences between sexes and gross national income.ResultsOverall, working in settings with potentially high exposure to dusts or fumes was associated with respiratory symptoms but not lung function differences. The most common occupation was farming. Compared to people not working in any of the 11 considered occupations, those who were farmers for ≥20 years were more likely to have chronic cough (OR 1.52, 95% CI 1.19–1.94), wheeze (OR 1.37, 95% CI 1.16–1.63) and dyspnoea (OR 1.83, 95% CI 1.53–2.20), but not lower FVC (β=0.02 L, 95% CI −0.02–0.06 L) or lower FEV1/FVC (β=0.04%, 95% CI −0.49–0.58%). Some findings differed by sex and gross national income.ConclusionAt a population level, the occupational exposures considered in this study do not appear to be major determinants of differences in lung function, although they are associated with more respiratory symptoms. Because not all work settings were included in this study, respiratory surveillance should still be encouraged among high-risk dusty and fume job workers, especially in low- and middle-income countries.
A modified Delphi approach to determine current treatment advances for the development of a resuscitation program for maternal cardiac arrest
Authors: Shields Andrea D. , Battistelli Jacqueline D. , Kavanagh Laurie B. , Thomson Brook A. , Nielsen Peter E. 
Published: August 2022

Abstract
Objective
Maternal cardiac arrest is a rare and complex process requiring pregnancy-specific responses and techniques. The goals of this study were to (1) identify, evaluate, and determine the most current best practices to treat this patient population and (2) establish a standardized set of guidelines to serve as a foundation for a future educational simulation-based curriculum.

Study design
We used a three-step modified Delphi process to achieve consensus. Twenty-two healthcare experts from across North America agreed to participate in the expert panel. In round 1, 12 pregnancy-specific best practice statements were distributed to the expert panel. Panelists anonymously ranked these using a 7-point Likert scale and provided feedback. Round 2 consisted of a face-to-face consensus meeting where statements that had not already achieved consensus were discussed and then subsequently voted upon by the panelists.

Results
Through two rounds, we achieved consensus on nine evidence-based pregnancy-specific techniques to optimize response to maternal cardiac arrest. Round one resulted in one of the 12 best practice statements achieving consensus. Round two resulted in six of the remaining 12 gaining consensus. Best practice techniques involved use of point-of care ultrasound, resuscitative cesarean delivery, cardiopulmonary resuscitation techniques, and the use of extracorporeal cardiopulmonary resuscitation.

Conclusion
The results of this study provide the foundation to develop an optimal, long-term strategy to treat cardiac arrest in pregnancy. We propose these nine priorities for standard practice, curricula, and guidelines to treat maternal cardiac arrest and hope they serve as a foundation for a future educational curriculum.
PNPLA3 and TM6SF2 genetic variants and hepatic fibrosis and cirrhosis in Pakistani chronic hepatitis C patients: a genetic association study
Authors: Rauff Bisma , Alzahrani Badr , Chudhary Shafiq A. , Nasir Bilal , Mahmood Saqib , Bhinder Munir Ahmad , Faheem Muhammad , Amar Ali 
Published: August 2022

Abstract
Background
The present study investigates if common missense functional variants p.I148M and p.E167K in PNPLA3 and TM6SF2 genes, respectively, associate with development of hepatic fibrosis and cirrhosis in a geographically novel cohort of Pakistani chronic hepatitis C (CHC) patients.

Methods
In total, 502 Pakistani CHC patients [242 males, median age 40 years, 220 with significant hepatic fibrosis, including 114 with cirrhosis] were genotyped for PNPLA3 and TM6SF2 variants using TaqMan genotyping assays. Associations between genotypes, biochemical and clinical parameters were evaluated.

Results
Genotypic distributions for PNPLA3 and TM6SF2 polymorphisms conformed to Hardy–Weinberg equilibrium and did not associate with fibrosis grades ≥ F2 or cirrhosis in any of the genetic models tested (all p =  > 0.05). PNPLA3 and TM6SF2 variants did not modulate baseline characteristics and serum markers of liver injury in CHC patients. Similarly, increasing number of risk alleles of PNPLA3 and TM6SF2 polymorphisms had no trend effect on serum liver enzyme activities or proportion of CHC patients with significant or advanced fibrosis or cirrhosis (p =  > 0.05). The same trend of no association with hepatic fibrosis or cirrhosis persisted in the multivariate logistic regression models adjusting for age, gender, body mass index and HCV viral load (p =  > 0.05).

Conclusions
PNPLA3 and TM6SF2 variants do not appear to modulate development of hepatic fibrosis or cirrhosis in present CHC patients of Pakistani origin, and may be of more relevance in liver pathology involving abnormalities in hepatic fat accumulation. These results also reflect the divergent associations observed for different genetic modifiers of hepatic fibrosis and cirrhosis in distinct ethnicities.
Effect of skeletal muscle loss during neoadjuvant imatinib therapy on clinical outcomes in patients with locally advanced GIST
Authors: Ding Ping’an , Guo Honghai , He Xiaoxiao , Sun Chenyu , Lowe Scott , Bentley Rachel , Zhou Qin , Yang Peigang , Tian Yuan , Liu Yang , Yang Li , Zhao Qun 
Published: August 2022

Abstract
Background
Currently, the effect of skeletal muscle loss during neoadjuvant imatinib therapy on clinical outcomes in patients with locally advanced gastrointestinal stromal tumors (LA-GIST) remains unclear. This study aims to investigate the relationship between changes in skeletal muscle and postoperative complications, survival and tumor response in patients with LA-GIST during neoadjuvant therapy with imatinib.

Methods
We retrospectively analyzed pre- and post-treatment computed tomography images of 57 GIST patients who underwent radical surgery after neoadjuvant therapy with imatinib from January 2013 to March 2019. Skeletal muscle index (SMI) was measured at the L3 vertebral level in all patients. A cut-off value (SMI < 52.3 cm2/m2 and < 38.6 cm2/m2 for men and women, respectively) published in a previous study was used to define sarcopenia. Based on gender, we defined ΔSMI (%)/250 days above 9.69% for men and ΔSMI (%)/250 days above 7.63% for women as significant muscle loss (SML). Factors associated with postoperative complications and tumor response were analyzed using logistic regression, and predictors affecting patient prognosis were analyzed using Cox regression.

Results
Of the 57 patients, sarcopenia was present before and after neoadjuvant therapy in 20 (35.09%) and 28 (49.12%) patients, respectively. It was not associated with immediate or long-term clinical outcomes. However, patients with SML during neoadjuvant therapy had a higher incidence of postoperative complications (60.00% vs. 25.00%, p = 0.008), worse pathological regression (44.00% vs. 75.00%, p = 0.017) and worse 3-year survival (Male, 68.75% vs. 95.45%, p = 0.027; Female, 66.67% vs. 100.00%, p = 0.046) than patients without SML.

Conclusion
The development of SML during neoadjuvant therapy in LA-GIST patients, rather than pre- and post-treatment sarcopenia, is a major prognostic factor for the long-term prognosis and is also associated with recent postoperative complication rates and pathological regression.
Relationship between diet quality and depression among Iranian older adults in Tehran
Authors: Chegini Maedeh , Shirani Pedram , Omidvar Nasrin , Eini-Zinab Hassan , Pour-Ebrahim Fatemeh , Rezazadeh Arezoo 
Published: August 2022

Abstract
Background
Depression is one of the prevalent mental disorders that is common in older ages. Evidence suggests that dietary intake status may potentially be associated with depression. However, this association has not been well studied in older adults, and the nature of the association remains unclear. This study aimed to investigate the association between diet quality and depression in free-living older adults living in Tehran city.

Methods
This cross-sectional study was conducted on 583 older adults (279 men and 304 women) aged 60 to 80 years living in Tehran city, selected by the systematic cluster sampling method. Individuals' dietary intake was determined by two non-consecutive 24-h dietary recalls, and diet quality was assessed calculating score of Healthy Eating Index-2015 (HEI-2015). The validated short form of the Geriatric Depression Scale (GDS-11) was used to assess depression status. A logistic regression model was used to assess the chance of depression across tertiles of HEI-2015 score.

Results
The point prevalence of depression was 22.5%, which was significantly higher in women (91 (69.5%) women vs. 40 (30.5%) men). A higher percentage of seniors at the higher tertile of HEI score were women, belonged to Fars ethnicity and had a higher score of activity of daily living (ADL). After adjustment for all potential confounders, the trend of depression chance was significantly decreased in those with higher HEI-2015 scores (p-for trend < 0.05).

Conclusion
Higher quality of diet was associated with a lower possibility of depression in the studied participants. Further studies are required to investigate the possible causal relationship.
Loneliness, loneliness literacy, and change in loneliness during the COVID-19 pandemic among older adults: a cross-sectional study
Authors: Hsu Hui-Chuan , Chao Shiau-Fang 
Published: August 2022

Abstract
Background
Loneliness has become a significant public health concern for older people. However, little is known about the association of loneliness, loneliness literacy, and changes in loneliness during the COVID-19 pandemic with mental well-being. The purpose of this study was to explore whether loneliness literacy is related to a lower risk of loneliness, increased loneliness during the COVID-19 pandemic, and improved mental well-being for community-based older adults.

Methods
A telephone survey was conducted to collect data from older adults aged 65 years or older in Taiwan (n = 804). Loneliness, change in loneliness during COVID-19, and loneliness literacy were the main variables. Mental well-being was assessed by depressive symptoms and life satisfaction. Related factors included personal level (demographics, health conditions, health behaviors, and problem-focused/ emotion-focused coping strategies), interpersonal level (marital status, living arrangements, social support, social participation, leisure activities, and social interactions during COVID-19), and societal level (areas and regions) factors.

Results
Four dimensions of loneliness literacy were identified by factor analysis: self-efficacy, social support, socialization, and in-home support. Self-efficacy and in-home support were related to lower loneliness. Lower self-efficacy, higher social support, and higher socialization were related to changes (increases) in loneliness during COVID-19. In-home support may prevent depressive symptoms, while self-efficacy was beneficial for better life satisfaction. In addition, emotion-focused coping may increase loneliness during COVID-19, while satisfaction with family support would be a protective factor against loneliness.

Conclusion
Loneliness literacy is related to loneliness and increased loneliness during the COVID-19 pandemic. Building up an age-friendly community with embedded services/information and learning positive coping and mental resilience strategies are suggested.
Psychosocial and behavioral health indicators among immigrant and non-immigrant recent mothers
Authors: Ewesesan Roheema , Chartier Mariette J. , Nickel Nathan C. , Wall-Wieler Elizabeth , Urquia Marcelo L. 
Published: August 2022

Abstract
Background
Perinatal risk factors can vary by immigration status. We examined psychosocial and behavioral perinatal health indicators according to immigration status and immigrant characteristics.

Methods
We conducted a population-based cross-sectional study of 33,754 immigrant and 172,342 non-immigrant childbearing women residents in Manitoba, Canada, aged 15–55 years, who had a live birth and available data from the universal newborn screen completed within 2 weeks postpartum, between January 2000 and December 2017. Immigration characteristics were from the Canadian federal government immigration database. Logistic regressions models were used to obtain Odds Ratios (OR) with 95% confidence intervals (CI) for the associations between immigration characteristics and perinatal health indicators, such as social isolation, relationship distress, partner violence, depression, alcohol, smoking, substance use, and late initiation of prenatal care.

Results
More immigrant women reported being socially isolated (12.3%) than non-immigrants (3.0%) (Adjusted Odds Ratio (aOR): 6.95, 95% CI: 6.57 to 7.36) but exhibited lower odds of depression, relationship distress, partner violence, smoking, alcohol, substance use, and late initiation of prenatal care. In analyses restricted to immigrants, recent immigrants (< 5 years) had higher odds of being socially isolated (aOR: 9.04, 95% CI: 7.48 to 10.94) and late initiation of prenatal care (aOR: 1.50, 95% CI: 1.07 to 2.12) compared to long-term immigrants (10 years or more) but lower odds of relationship distress, depression, alcohol, smoking and substance use. Refugee status was positively associated with relationship distress, depression, and late initiation of prenatal care. Secondary immigrants, whose last country of permanent residence differed from their country of birth, had lower odds of social isolation, relationship distress, and smoking than primary migrants. There were also differences by maternal region of birth.

Conclusion
Immigrant childbearing women had a higher prevalence of social isolation but a lower prevalence of other psychosocial and behavioral perinatal health indicators than non-immigrants. Health care providers may consider the observed heterogeneity in risk to tailor care approaches for immigrant subgroups at higher risk, such as refugees, recent immigrants, and those from certain world regions.