bluuebunny/crossref_metadata_2025_split huggingface dataset:
HRS Regulates Small Extracellular Vesicle PD-L1 Secretion and Is Associated with Anti–PD-1 Treatment Efficacy
Authors: Xiao Bo-Lin , Wang Xiao-Le , Xia Hou-Fu , Zhang Lin-Zhou , Wang Kui-Ming , Chen Zhuo-Kun , Zhong Ya-Hua , Jiang Huan-Gang , Zhou Fu-Xiang , Wang Wei , Chen Gai-Li , Chen Gang 
Published: December 2022

Abstract

PD-L1 localized to immunosuppressive small extracellular vesicles (sEV PD-L1) contributes to tumor progression and is associated with resistance to immune-checkpoint blockade (ICB) therapy. Here, by establishing a screening strategy with a combination of tissue microarray (TMA), IHC staining, and measurement of circulating sEV PD-L1, we found that the endosomal sorting complex required for transport (ESCRT) member protein hepatocyte growth factor–regulated tyrosine kinase substrate (HRS) was the key regulator of circulating sEV PD-L1 in head and neck squamous cell carcinoma (HNSCC) patients. Increased HRS expression was found in tumor tissues and positively correlated with elevated circulating sEV PD-L1 in patients with HNSCC. The expression of HRS was also negatively correlated to the infiltration of CD8+ T cells. Knockdown of HRS markedly reduced PD-L1 expression in HNSCC cell–derived sEVs, and these sEVs from HRS knockdown cells showed decreased immunosuppressive effects on CD8+ T cells. Knockout of HRS inhibited tumor growth in immunocompetent mice together with PD-1 blockade. Moreover, a higher HRS expression was associated with a lower response rate to anti–PD-1 therapy in patients with HNSCC. In summary, our study reveals HRS, the core component of ESCRT-0, regulates sEV PD-L1 secretion, and is associated with the response to ICB therapy in patients with HNSCC, suggesting HRS is a promising target to improve cancer immunotherapy.
Novel Cardiokine GDF3 Predicts Adverse Fibrotic Remodeling After Myocardial Infarction
Authors: Masurkar Nihar , Bouvet Marion , Logeart Damien , Jouve Charlène , Dramé Fatou , Claude Olivier , Roux Maguelonne , Delacroix Clément , Bergerot Damien , Mercadier Jean-Jacques , Sirol Marc , Gellen Barnabas , Livrozet Marine , Fayol Antoine , Robidel Estelle , Trégouët David-Alexandre , Marazzi Giovanna , Sassoon David , Valente Mariana , Hulot Jean-Sébastien 
Published: December 2022

Background:
Myocardial infarction (MI) induces a repair response that ultimately generates a stable fibrotic scar. Although the scar prevents cardiac rupture, an excessive profibrotic response impairs optimal recovery by promoting the development of noncontractile fibrotic areas. The mechanisms that lead to cardiac fibrosis are diverse and incompletely characterized. We explored whether the expansion of cardiac fibroblasts after MI can be regulated through a paracrine action of cardiac stromal cells.

Methods:

We performed a bioinformatic secretome analysis of cardiac stromal PW1
+
cells isolated from normal and post-MI mouse hearts to identify novel secreted proteins. Functional assays were used to screen secreted proteins that promote fibroblast proliferation. The expressions of candidates were subsequently analyzed in mouse and human hearts and plasmas. The relationship between levels of circulating protein candidates and adverse post-MI cardiac remodeling was examined in a cohort of 80 patients with a first ST-segment–elevation MI and serial cardiac magnetic resonance imaging evaluations.

Results:

Cardiac stromal PW1
+
cells undergo a change in paracrine behavior after MI, and the conditioned media from these cells induced a significant increase in the proliferation of fibroblasts. We identified a total of 12 candidates as secreted proteins overexpressed by cardiac PW1
+
cells after MI. Among these factors, GDF3 (growth differentiation factor 3), a member of the TGF-β (transforming growth factor-β) family, was markedly upregulated in the ischemic hearts. Conditioned media specifically enriched with GDF3 induced fibroblast proliferation at a high level by stimulation of activin-receptor–like kinases. In line with the secretory nature of this protein, we next found that GDF3 can be detected in mice and human plasma samples, with a significant increase in the days after MI. In humans, higher GDF3 circulating levels (measured in the plasma at day 4 after MI) were significantly associated with an increased risk of adverse remodeling 6 months after MI (adjusted odds ratio, 1.76 [1.03–3.00];
P
=0.037), including lower left ventricular ejection fraction and a higher proportion of akinetic segments.

Conclusions:
Our findings define a mechanism for the profibrotic action of cardiac stromal cells through secreted cardiokines, such as GDF3, a candidate marker of adverse fibrotic remodeling after MI.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01113268.
Kekeliruan dalam Penentuan Nama Perawi: Kajian terhadap Sanad dalam al-Kutub al-Sitta
Authors: Nadzif Wan Kamal , Shamsudin Roshimah 
Published: December 2022

Abstract
The individuals who narrated the hadith in the Six Books attracted the specific attention of hadith scholars. Their backgrounds and positions from the perspective of al-jarh and al-taʿdil were scrutinised. However, there were some errors in determining the narrator, especially when the name found on the chains of transmission is not the original name. This created difficulties for hadith researchers when directly referring to the book of rijal as the narrator’s biography traditionally used the narrator’s real name. Even the entry of a particular narrator’s name sometimes could not be found. Hence, this article aims to examine the error in the names of eight individuals who narrated the hadith in the Six Books. In this regard, the qualitative research was carried out using the content analysis tool on the texts of hadiths and works of rijal. The results showed that this error stemmed from excerpts from other books, identical names of narrators, differences between manuscripts, attributions to ancestral names, inverted paternal and grandfather names, and errors in the narrators’ names. In short, the ability of al-jarh and al-taʿdil scholars to identify errors in the name of the narrators reveals their thoroughness in criticising the chains of transmission of hadith.
Isu Penyelewengan Tafsiran Ayat Al-Quran oleh Samina Ali dalam Saluran TEDx Talk
Authors: Razzak Monika @ Munirah Abd , Elias Nurul Afifah , Rahim Nik Mohd Zaim Ab. 
Published: December 2022

Abstract
The modernity that occurs in Information Technology has resulted in the dumping of information in the digital world. This is inevitable as the use of technology in the millennium period has become essential for all parties. At the same time, the development of new media has also increased, and It has left an impact on society globally. Information greatly influences cultures, beliefs -especially religious beliefs-, ideologies, thoughts, value systems, behaviours and social interactions. This study discussed the issues raised by Samina Ali in the TEDx Talks channel. The methodology used was a qualitative design using content analysis as the data analysis method. The results of this study showed that the interpretation presented by Samina Ali is in direct contradiction to the interpretation agreed upon by authoritative scholars. Therefore, Muslims need to be more cautious in seeking information about Islam in the TED Talks YouTube channel as not everyone is qualified to speak about religion without expertise and authority in that field.
Prospects for Enhancing Climate Services in Agriculture
Authors: Kim Kwang-Hyung , Hewitt Chris D. , Kanamaru Hideki , Alvar-Beltrán Jorge , Heureux Ana , Park Sook-Young , Jung Min-Hye , Stefanski Robert 
Published: December 2022

Abstract
Agricultural stakeholders can effectively manage the risks and opportunities arising from climate change and variability by enhancing climate services in agriculture. Key to understanding and addressing the climate challenge is the provision and the use of climate information to aid decision-makers and policy-makers. Climate services are now integral to the United Nations Framework Convention on Climate Change, the Intergovernmental Panel on Climate Change’s Assessment Reports, governments’ national adaptation plans, funding bodies, and a growing number of sectors and industries worldwide. The article provides our personal perspective, experience, and views on the important and timely issue of managing better the risks and opportunities to the agriculture sector and community that are arising from changes in climate. We describe a framework to help drive action to tackle the climate challenge comprising enhanced knowledge and information products, efficient information delivery and use, and assured policy and institutional support, in an iterative loop.
COVID-19 Outbreaks Linked to Workplaces, 23 US Jurisdictions, August–October 2021
Authors: Luckhaupt Sara E. , Horter Libby , Groenewold Matthew R. , de Perio Marie A. , Robbins Cheryl L. , Sweeney Marie Haring , Thomas Isabel , Valencia Diana , Ingram Amanda , Heinzerling Amy , Nguyen Alyssa , Townsend Emily B. , Weber Rachel C. , Reichbind Diana , Dishman Hope , Kerins Janna L. , Lendacki Frances R. , Austin Connie , Dixon Liana , Spillman Brooke , Simonson Sean , Tonzel Julius , Krueger Anna , Duwell Monique , Bachaus Brian , Rust Britney , Barrett Colleen , Morrison Brooke , Owers Bonner Katharine A. , Karlsson Nicole D. , Angelon-Gaetz Kim , McClure Elizabeth S. , Kline Kelly E. , Dangar Dhara , Reed Chasey , Karpowicz Jacqueline , Anderson Shoana M. , Cantor Sophia , Chaudhary Ifrah , Ellis Esther M. , Taylor Marissa L. , Sedon Allison , Kocharian Anna , Morris Collin , Samson Marsha E. , Mangla Anil T. 
Published: December 2022

Objectives: Early in the COVID-19 pandemic, several outbreaks were linked with facilities employing essential workers, such as long-term care facilities and meat and poultry processing facilities. However, timely national data on which workplace settings were experiencing COVID-19 outbreaks were unavailable through routine surveillance systems. We estimated the number of US workplace outbreaks of COVID-19 and identified the types of workplace settings in which they occurred during August–October 2021. Methods: The Centers for Disease Control and Prevention collected data from health departments on workplace COVID-19 outbreaks from August through October 2021: the number of workplace outbreaks, by workplace setting, and the total number of cases among workers linked to these outbreaks. Health departments also reported the number of workplaces they assisted for outbreak response, COVID-19 testing, vaccine distribution, or consultation on mitigation strategies. Results: Twenty-three health departments reported a total of 12 660 workplace COVID-19 outbreaks. Among the 12 470 workplace types that were documented, 35.9% (n = 4474) of outbreaks occurred in health care settings, 33.4% (n = 4170) in educational settings, and 30.7% (n = 3826) in other work settings, including non–food manufacturing, correctional facilities, social services, retail trade, and food and beverage stores. Eleven health departments that reported 3859 workplace outbreaks provided information about workplace assistance: 3090 (80.1%) instances of assistance involved consultation on COVID-19 mitigation strategies, 1912 (49.5%) involved outbreak response, 436 (11.3%) involved COVID-19 testing, and 185 (4.8%) involved COVID-19 vaccine distribution. Conclusions: These findings underscore the continued impact of COVID-19 among workers, the potential for work-related transmission, and the need to apply layered prevention strategies recommended by public health officials.
Survival Outcomes Associated With the Size of Opioid Prescriptions in the Management of Chronic Pain Related to Advanced Nasopharyngeal Carcinoma
Authors: Li Kunhong , Zhang Shi , Sun Wei , Zhang Yaodong , Yu Minji , Zhang Guangwei , Yu Weiguang 
Published: December 2022

Objective Patients with advanced nasopharyngeal carcinoma (ANC) often experience chronic pain. Opioids are generally recommended to treat tumor-related pain, but increased opioid use may lead to detrimental aftereffects, particularly with respect to tumor progression, resulting in reduced quality of life and increased risk of death. Our objective was to investigate whether the high size of opioid prescriptions is associated with poor overall survival (OS) in patients with ANC. Methods A consecutive cohort of patients with newly diagnosed ANC who underwent high or low opioid prescription size treatment during 2012–2019 was retrospectively identified from our medical institutions. Survival was estimated with the Kaplan–Meier method with a log-rank test. Multivariate binary logistic regression was used to assess the association between opioid use and OS, adjusting for age, sex, body mass index (BMI), Eastern Collaborative Oncology Group performance status (ECOG PS), and ANC histology. The criterion to distinguish between the high opioid prescription size group [HD] and the low opioid prescription size group [LD] was 5 mg of oral morphine equivalents (OME) per 24 hours. Results The cohort consisted of 244 consecutive patients (HD: n = 120, median age = 66 years [range, 40–81 years]; LD: n = 124, median age = 65 years [40–82 years]. Patients who underwent treatment with a high opioid prescription size had a worse median OS than those who underwent treatment with a low opioid prescription size (5.1 vs 6.6 months), and the high opioid prescription size was associated with a remarkable 48% higher risk of death than the low opioid prescription size (HR 1.48, 95% CI 1.11–1.98; P = .005). The cumulative dose of opioids greater than or equal to 500 mg of OME was associated with a higher risk of death, adjusted for age, sex, BMI, ECOG PS, and ANC histology. Conclusions In patients with newly diagnosed ANC experiencing palliative care, a high opioid prescription size may be associated with shorter OS than a low opioid prescription size.
Safety of bloodless open-heart surgery on cardiopulmonary bypass in selected children: A single center experience with minimal invasive extracorporeal circulation
Authors: Kayoum Anas Abdul , Rivera Flores Estefania , Reyes Marcelle , Almasarweh Saleem I , Ojito Jorge , Burke Redmond P , Sasaki Jun 
Published: December 2022

Introduction Bloodless cardiac surgery refers to open-heart surgery without blood or blood products. The cardiopulmonary bypass (CPB) circuits are primed with crystalloid solely, and there is no intraoperative blood transfusion. Methods Our program considers bloodless congenital cardiac surgery with a minimal invasive extracorporeal circulation (MiECC) system for patients above 10 kg of weight. We performed a single-center retrospective cohort study of all consecutive patients undergoing bloodless cardiac surgery for congenital heart defects between January 2016 and December 2018. Results A total of 164 patients were reviewed (86 male and 78 female) at a median age of 9.6 years (interquartile range (IQR), 4.5–15), a weight of 32 kg (IQR, 16–55), preoperative hemoglobin 13.7 g/dl (IQR, 12.6–14.9), and preoperative hematocrit of 40.4% (IQR, 37.2–44.3). Median CPB time was 81.5 min (IQR, 58–125), and median hematocrit coming off CPB was 26% (IQR, 23–29.7). The congenital heart surgery risk (STAT) category was distributed in STAT 1 for 70, STAT 2 for 80, STAT 3 for 9, and STAT 4 for 5 patients. Most patients (95%) were extubated in the operating room with a low complication rate during the hospital stay (14.6%). Only 6 (4%) patients needed a blood transfusion during the postoperative period, with a higher incidence of complications during the hospital course ( p < 0.001). Conclusions Bloodless congenital heart surgery with MiECC system is safe in low-surgical-risk patients. Our patients had a low rate of complications and short hospital stays.
Apixaban-Associated Intracranial Hemorrhage in a Patient With Elevated International Normalized Ratio
Authors: Pathan Sophia , Genco Andrew T. 
Published: December 2022

Apixaban has been associated with prolongation of the international normalized ratio (INR), but data surrounding the extent of elevation and its clinical significance are limited. Due to interaction between apixaban and the prothrombin assay, elevations in INR in patients receiving apixaban are common and not always grounds for concern. However, in high risk patients, elevations can represent a need for closer monitoring. This case summarizes an 82-year-old woman with a history of atrial fibrillation and left middle cerebral artery strokes with no residual deficits. She presented with right-sided hemiparesis and aphasia and underwent a mechanical thrombectomy with TICI 2b recanalization of a left M1 occlusion. Post-thrombectomy, she was found to have a left atrial thrombus and 10 days later was started on apixaban 5 mg twice daily. On the fourth day of apixaban therapy, she experienced an INR increase to 2.3, prompting initiation of a vitamin K challenge for nutritional deficiency. Despite initial improvement, her INR increased to 2.7 a week after apixaban was initiated, coinciding with a decline in mental status and an apixaban peak level of 435.6 ng/mL (reference range 91-321 ng/mL). A computed tomography (CT) scan of her head showed new intracranial hemorrhage in the area of her previous infarction, prompting apixaban reversal with andexanet alfa. Unfortunately, the patient expired. This case report highlights the importance and difficulty in performing therapeutic drug monitoring in patients receiving oral anti-factor Xa inhibitors, revealing a downside to administration of high-risk medications that do not have readily available monitoring.
Optimization of Titanium Grade 2 sheet forming by roller blank holder method
Authors: Seçgin Ömer , Özsert İbrahim 
Published: December 2022

Incremental forming is a rapid prototype production method, which can be used in different industrial applications. In this context, it can be used especially in forming of Titanium Grade 2 sheet as depending on the types of manufacture. The main problem of the incremental forming method is that the wall thickness of the piece obtained after the process is not homogeneous. In this study, Titanium Grade 2 sheet was formed 60° axially symmetrical cone geometry using the roller blank holder method (TPIF-RL), which is a new approach. This method provides bigger wall thickness than the conventional incremental forming method considering its results. In this study, it was aimed to investigate the effectiveness of the new roller blank holder method on titanium material. In the experiments, the axisymmetrical piece with a height of 40 mm was formed (the forming angle is 60° with the horizontal). Feedrate, clamping pressure, increment, and forming tool diameter were used as parameters. Forming force, surface roughness, and wall thickness distributions obtained as a result of experimental studies were examined statistically. The interactions of the parameters were evaluated, and optimum levels of forming parameters were determined for the roller blank holder method. In addition, by using gray relational analysis, parameter levels of three dependent variables (forming force, surface roughness, and sheet thickness) were defined to optimize at the same time. As a result, bigger wall thickness was obtained with a low clamping force considering roller blank holder method. It was determined the levels that optimize the three parameters together were 2 bar pressure, 500 mm/min feed rate, 0.25 mm increment, and 5 mm forming tool diameter. Bigger wall thickness was obtained with a low clamping force considering roller blank holder method.
Relapses are common in severe hematologic systemic lupus erythematosus and may be prevented by early institution of immunosuppressive agents: Α real-life single-center study
Authors: Moysidou Georgia-Savina , Garantziotis Panagiotis , Nikolopoulos Dionysis , Katsimbri Pelagia , Fanouriakis Antonis , Boumpas Dimitrios T 
Published: December 2022

Background Hematologic manifestations are common in systemic lupus erythematosus (SLE), either at initial presentation or during the course of the disease, but data regarding their natural history are scarce. Objective To describe the characteristics, treatments, and outcomes of severe hematological manifestations in a large cohort of lupus patients. Methods Retrospective cohort study of patients in the “Attikon” lupus cohort who had a history of a severe hematologic manifestation, defined as autoimmune hemolytic anemia (AIHA) with hemoglobin < 8 g/dL, thrombocytopenia with platelet count < 30,000/mm3, Evans syndrome with hemoglobin < 8 g/dL, and/or platelet count < 30,000/mm3, neutropenia with < 500 neutrophils/mm3, thrombotic microangiopathy (TMA)/thrombotic thrombocytopenic purpura (TTP)-like syndrome, or macrophage activation syndrome (MAS). Demographic and clinical characteristics, treatments, and outcomes were recorded. Results From over 300 patients with hematologic manifestations, 41 qualified as severe (70.7% women, mean [SD] age at SLE diagnosis 42.6 [18.0] years). Hematologic manifestations preceded SLE diagnosis in 13 patients (31.7%), was concomitant to SLE diagnosis in 16 patients (39%), and occurred during the course of the disease in 12 (29.3%) patients, with a mean (SD) disease duration of 8.7 (5.5) years. Thrombocytopenia was the most common severe hematological manifestation (56.1%), followed by AIHA (17.1%) and TTP-like syndrome (12.2%). For initial treatment, all patients were treated with glucocorticoids (GC), while rituximab and cyclophosphamide were the most frequently used immunosuppressive agents. Following initial treatment, relapse occurred in 22 patients (53.7%). Compared to patients that did not relapse, those that relapsed had less often received concomitant immunosuppressive agents following treatment of initial episode ( n = 17/23, 73.9% vs 5/17, 29.4%, p = 0.005). Conclusion Severe hematologic disease in SLE has a high risk of relapse, which may be mitigated by the early institution of GC-sparing agents.
Possible heart failure caused by osimertinib in a lung cancer patient
Authors: Ruiz-Briones Paula , Escudero-Vilaplana Vicente , Collado-Borrell Roberto , Vicente-Valor Juan , Alvarez Rosa , Villanueva-Bueno Cristina , Narrillos-Moraza Álvaro , Herranz Ana , Sanjurjo Maria 
Published: December 2022

Introduction Osimertinib is a third-generation tyrosine kinase inhibitor (TKI) indicated for the treatment of epidermal growth factor receptor mutated non-small cell lung cancer (NSCLC). It has demonstrated better results concerning effectiveness than other TKIs for the same indication. However, despite a good safety profile, it could produce some cardiotoxicity that does not occur with other drugs of the same group. Case report We report the evolution and management of a female patient diagnosed with NSCLC who developed a grade 3 cardiotoxicity due to treatment with osimertinib. This patient suffered from a left bundle branch block, dyslipidemia, and hypertension as cardiovascular risk factors. After a long period of treatment with osimertinib, she developed a severe heart failure (HF) with an important decrease in left ventricular ejection fraction (LVEF), which triggered an admission to the oncology unit for eight days. Management and outcomes Treatment with osimertinib was first suspended and then resumed after stabilization of the HF. She also developed atrial fibrillation during admission and has required narrow cardiac monitoring and management since the debut of the HF. After evaluating the benefit-risk balance, osimertinib was reintroduced and the patient continues in treatment at the moment, although the baseline LVEF is not recovered. Discussion There is scarce evidence in the literature concerning HF and important LVEF decrease due to osimertinib. However, its severity and repercussion for the patient justify the thorough screening of cardiovascular risk factors before starting the therapy.