bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased risk of high-grade prostate cancer among testicular cancer survivors
Authors: Zhang Hong , Yang Hongmei , Bandyopadhyay Sanjukta , Milano Michael T. , Fung Chunkit , Messing Edward M. , Chen Yuhchyau 
Published: February 2022

Introduction
Testicular cancer survivors (TCS) have an increased risk of additional cancers, including prostate cancer. Our understanding of the natural history of prostate cancer in testicular cancer survivors is very limited due to its rare incidence.

Methods
Using the Surveillance, Epidemiology, and End Results (SEER) Registry from 1978 to 2011, we identified 282 TCS with subsequent prostate cancer and examined the tumor grade and clinical outcomes in contrast to men with primary prostate cancer in the general population.

Results
TCS with a subsequent prostate cancer diagnosis were more likely to be diagnosed at a younger age than men with primary prostate cancer (65.2% vs. 37.6% for age ≤65, 34.8% vs. 62.4% for age >65, p<0.001) and were more likely to have grade III/IV tumors (46.2% vs. 37.0%, p<0.002). Longer latency between testicular and prostate cancer diagnoses was associated with a higher risk of grade III/IV (p<0.001) cancer. Despite the increased risk for high-grade tumors, 10-year prostate cancer-specific survival and overall survival were not significantly different between TCS and men with primary prostate cancer. Based on the available information in SEER, we found that prior history of radiotherapy for testicular cancer had no impact on tumor grade or survival outcomes.

Conclusions
Prostate cancer in TCS was more likely to be diagnosed at a younger age and with higher grades. Risks of grade III/IV disease increased with longer latency between testicular and prostate cancer diagnoses. Radiotherapy for testicular cancer did not appear to have a significant impact on the outcome of subsequent prostate cancer.
Hour-1 bundle adherence was associated with reduction of in-hospital mortality among patients with sepsis in Japan
Authors: Umemura Yutaka , Abe Toshikazu , Ogura Hiroshi , Fujishima Seitato , Kushimoto Shigeki , Shiraishi Atsushi , Saitoh Daizoh , Mayumi Toshihiko , Otomo Yasuhiro , Hifumi Toru , Hagiwara Akiyoshi , Takuma Kiyotsugu , Yamakawa Kazuma , Shiino Yasukazu , Nakada Taka-aki , Tarui Takehiko , Okamoto Kohji , Kotani Joji , Sakamoto Yuichiro , Sasaki Junichi , Shiraishi Shin-ichiro , Tsuruta Ryosuke , Masuno Tomohiko , Takeyama Naoshi , Yamashita Norio , Ikeda Hiroto , Ueyama Masashi , Gando Satoshi 
Published: February 2022

BackgroundThe updated Surviving Sepsis Campaign guidelines recommend a 1-hour window for completion of a sepsis care bundle; however, the effectiveness of the hour-1 bundle has not been fully evaluated. The present study aimed to evaluate the impact of hour-1 bundle completion on clinical outcomes in sepsis patients.MethodsThis was a multicenter, prospective, observational study conducted in 17 intensive care units in tertiary hospitals in Japan. We included all adult patients who were diagnosed as having sepsis by Sepsis-3 and admitted to intensive care units from July 2019 to August 2020. Impacts of hour-1 bundle adherence and delay of adherence on risk-adjusted in-hospital mortality were estimated by multivariable logistic regression analyses.ResultsThe final study cohort included 178 patients with sepsis. Among them, 89 received bundle-adherent care. Completion rates of each component (measure lactate level, obtain blood cultures, administer broad-spectrum antibiotics, administer crystalloid, apply vasopressors) within 1 hour were 98.9%, 86.2%, 51.1%, 94.9%, and 69.1%, respectively. Completion rate of all components within 1 hour was50%. In-hospital mortality was 18.0% in the patients with and 30.3% in the patients without bundle-adherent care (p = 0.054). The adjusted odds ratio of non-bundle-adherent versus bundle-adherent care for in-hospital mortality was 2.32 (95% CI 1.09–4.95) using propensity scoring. Non-adherence to obtaining blood cultures and administering broad-spectrum antibiotics within 1 hour was related to in-hospital mortality (2.65 [95% CI 1.25–5.62] and 4.81 [95% CI 1.38–16.72], respectively). The adjusted odds ratio for 1-hour delay in achieving hour-1 bundle components for in-hospital mortality was 1.28 (95% CI 1.04–1.57) by logistic regression analysis.ConclusionCompletion of the hour-1 bundle was associated with lower in-hospital mortality. Obtaining blood cultures and administering antibiotics within 1 hour may have been the components most contributing to decreased in-hospital mortality.
Apresentação
Authors: Souza Tiago Zanquêta de , Magalhães Solange Martins Oliveira 
Published: February 2022

Iniciamos o ano de 2022 ainda fazendo coro ao centenário de vida de Paulo Freire, e, por isso, também o homenageamos como patrono da Educação Brasileira, além de retomá-lo, nesse Dossiê, como autor potente – nacional e internacionalmente – capaz de gerar mais e mais diálogos em defesa do debate democrático para uma educação autêntica e que sempre seja capaz de promover a dignidade humana. O ano de 2021 tornou-se, por isso, um marco histórico que nos apresentou centenas (se não milhares) de edições de revistas, coletâneas, dossiês, livros, outros, que mostraram a relevância do pensamento freireano no século XXI. Todas as manifestações, sejam quais fossem os diálogos apresentados, homenagearam não só a memória de Freire, mas o que ele nos inspira com sua vigorosa militância pela democracia e pela justiça social. Esse Dossiê também materializa uma homenagem à Paulo Freire, pois é transversalmente mediado pelo seu conceito de colaboração, ou seja, sustenta-se sua importância, o qual precisa se fazer presente no percurso integrado, não só da educação, mas também na própria condução da produção do conhecimento.
Mengatasi Intoleransi Beragama: Sebuah Tawaran Moderasi Beragama Perspektif Syiah
Authors: Syarif Dede 
Published: February 2022

Abstract Authoritatively promoted in 2019 by the government to counter religious radicalism, the study and implementation of religious moderation has taken more on Sunni viewpoint. Whereas, as a open conceptual, the discourse and practices of religious moderation potentially to develop in others Islamic madhab, such as Shia. This article investigates on how the Shia community struggling over discrimination by developing the middle position in religious practices. This article offers an alternative perspective on religious moderation by referring to the religious thoughts and practices carried out by the congregation of All-Indonesian Assembly of Ahl al-Bayt Association (IJABI). This paper aims to investigate a model of religious moderation from Shia perspective. The identification for religious moderation from Shia perspective refers to the definition, characteristics, and indicators from the Indonesian Ministry of Religious Affairs, which includes three pillars, namely moderation in religious thought, method of dakwah, and religious traditions and practices. This paper argues that the congregation of IJABI practices religious moderation which consist of a teaching of prioritizing morality over fiqh, the use of the term Ahl al-Bayt, the inclusive dakwah, and the mission of the IJABI to accommodate all Muslims from different madhabs, and the commemoration of Ashura in a local culture.
FAKTOR – FAKTOR YANG BERHUBUNGAN DENGAN STRESS KERJA PADA PETUGAS CALL CENTER NOMOR TUNGGAL PANGGILAN DARURAT (NTPD) JAKARTA SIAGA 112 DI BADAN PENANGGULANGAN BENCANA DAERAH DKI JAKARTA TAHUN 2021
Authors: Situmeang Kevin Antonio , Heryana Ade , Mustikawati Intan Silviana , Nabila Anggun 
Published: February 2022

Employees work stress can harm themselves and the company. The purpose of this study was to determine the factors associated with work stress on the call center officer of the Jakarta Emergency Call 112 (NTPD). Research design used cross sectional with quantitative approach. The study was conducted in April 2021 - August 2021. Sample were 40 participant that selected with total sampling method. Data was analyze in univariate and bivariate tests using the chi-square statistical test with α = 0.05. The results showed call center officers with female sex 21 people (52.5%), College 33 people (82.5%), no work stress 23 people (54,7%), moderate workload 21 people (52.5 %), positive work climate 24 people (60.0%). Based on bivariate analysis, it was found that there was a relationship between work stress of call center officers and education (p value = 0.029, PR = 2.571). Based on bivariate analysis, it was found that there was a relationship between work stress of call center officers and education (p value = 0.029, PR = 2.571). It is hoped that the company's management will conduct emergency training and communication training on a regular basis to help officers with low education be better prepared to serve the community. In addition, management provides stress management counseling activities and provides sports facilities and vacation activities for staff relaxation.
HUBUNGAN INTENSITAS KEBISINGAN DI LINGKUNGAN KERJA DENGAN PENINGKATAN TEKANAN DARAH PADA PEKERJA PT X SEMARANG
Authors: Dewi Aqila Tischana , Joko Tri , Darundiati Yusniar Hanani 
Published: February 2022

Noise from working environment can generate health impact on workers. Noise exposure which exceeds the treshold limit can affect the cardiovascular system, one of which is the increase of blood pressure. This research aims to determine the association between noise intensity and the increase of blood pressure on workers at PT X Semarang, a steel conduit manufacturing company. This is an observasional analitic study with cross-sectional design. The respondent amounted to 32 people taken with total sampling technique. The noise intensity measurement showed that the lowest noise intensity is in office area (59,7 dBA) while the highest is in factory B (88,12 dBA). The average age of the respondents is 40 years old with 8 years of working period. The average blood pressure before working is 124,06/81,34 mmHg and after working is 126,97/82,84 mmHg in which 71,9% respondents have an increase in systolic blood pressure and 68,8% in diastolic blood pressure. Bivariate analysis using fisher’s exact test showed that there is an association between noise intensity and the increase of diastolic blood pressure (p = 0,013; RP = 9,500; CI 95% = 1,641-54,994) but no association between noise intensity and the increase of systolic blood pressure (p = 0,075; RP = 5,938; CI 95% = 1,084-32,513). Among the confounding variables, there was an association between smoking habit and the increase of diastolic blood pressure (p = 0,022; RP = 7,000; CI 95% = 1,185-41,359) but not with the increase of systolic blood pressure (p = 0,433; RP = 2,600; CI 95% = 0,518-13,041). The conclusion of this research is noise intensity and smoking habit can affect the increase of diastolic blood pressure. The workers are advised to wear earplugs when working.
Radioactive waste treatment technology: a review
Authors: Tochaikul Gunjanaporn , Phattanasub Archara , Khemkham Piyatida , Saengthamthawee Kanjanaporn , Danthanavat Nuttapong , Moonkum Nutthapong 
Published: February 2022

Abstract
Radioactive waste is generated from activities that utilize nuclear materials such as nuclear medicine or power plants. Depending on their half-life, they emit radiation continuously, ranging from seconds to millions of years. Exposure to ionizing radiation can cause serious harm to humans and the environment. Therefore, special attention is paid to the management of radioactive waste in order to deal with its large quantity and dangerous levels. Current treatment technologies are still being developed to improve efficiency in reducing the hazard level and waste volume, to minimize the impact on living organisms. Thus, the aim of this study was to provide an overview of the global radioactive waste treatment technologies that have been released in 2019–2021.
Birch pollen associated soy allergy – possibilities in diagnostic and clinical relevance1)
Authors: Beyer Susanne , Sack Ulrich , Treudler Regina 
Published: February 2022

Abstract

Background: Birch pollen allergic individuals frequently suffer from food allergies in the form of an oral allergy syndrome after eating pome and stone fruits. These complaints are based on an immunological cross-reaction between pollen and food allergens. In the past, it has been shown that many birch pollen allergic patients are additionally not able to tolerate high protein soy products. Some severe immediate type reactions to soy have been observed. The cause for these immediate type reactions to soy is a Bet v 1 cross-reactive soy allergen called Gly m 4.

Methods: Using a collective of 73 birch pollen allergic patients with associated food allergy in Leipzig as an example, the results of a standardized questioning, prick-to-prick test with a soy drink, determination of specific IgE against rGly m 4, and basophil activation test with Gly m 4 are presented.

Results and conclusions: We showed that commercially available prick test extracts and determination of specific IgE against soy bean mix/f14 are not appropriate to diagnose birch pollen associated soy allergy. Generally, soy sensitization could be proven when a prick-to-prick-test with a soy drink and determination of specific IgE against rGly m 4 were done. A positive prick-to-prick test with a soy drink was found in 79% (55/70) of the birch pollen allergic patients with 89% (65/73) showing specific IgE for rGly m 4 (CAP>1). Although not every sensitization was clinically relevant, every third patient with a proven soy sensitization was diagnosed with a clinically relevant allergy to soy.
Estimation of steady-state quantities of an HMM with some rarely generated emissions
Authors: Zakrad Az-eddine , Nasroallah Abdelaziz 
Published: February 2022

Abstract
We propose to apply the importance sampling and the antithetic variates statistical techniques to estimate steady-state quantities of an Hidden Markov chain (HMM) of which certain emissions are rarely generated. Compared to standard Monte Carlo simulation, the use of these techniques, allow a significant reduction in simulation time. Numerical Monte Carlo examples are studied to show the usefulness and efficiency of the proposed approach.
A Review of Striking Force in Full-Contact Combat Sport Athletes: Effects of Different Types of Strength and Conditioning Training and Practical Recommendations
Authors: Uthoff Aaron , Lenetsky Seth , Reale Reid , Falkenberg Felix , Pratt Gavin , Amasinger Dean , Bourgeois Frank , Cahill Micheál , French Duncan , Cronin John 
Published: February 2022

ABSTRACT
To succeed in full contact combat sports like mixed martial arts, tae kwon do, and boxing, athletes must deliver a greater number of damaging strikes than they receive. Producing knockdowns, rendering unconsciousness, and scoring points can be accomplished through the application of high magnitudes of striking forces. There is evidence that striking forces can be enhanced through either nonspecific or specific strength and conditioning methods or a combination thereof. To better assist practitioners working with combat sport athletes, this article reviews current empirical evidence on how combat sport athletes respond to different methods of resistance training and offers practical recommendations for implementing nonspecific and specific exercises.
Striatal Indirect Pathway Dysfunction Underlies Motor Deficits in a Mouse Model of Paroxysmal Dyskinesia
Authors: Nelson Alexandra B. , Girasole Allison E. , Lee Hsien-Yang , Ptáček Louis J. , Kreitzer Anatol C. 
Published: February 2022

Abnormal involuntary movements, or dyskinesias, are seen in many neurologic diseases, including disorders where the brain appears grossly normal. This observation suggests that alterations in neural activity or connectivity may underlie dyskinesias. One influential model proposes that involuntary movements are driven by an imbalance in the activity of striatal direct and indirect pathway neurons (dMSNs and iMSNs, respectively). Indeed, in some animal models, there is evidence that dMSN hyperactivity contributes to dyskinesia. Given the many diseases associated with dyskinesia, it is unclear whether these findings generalize to all forms. Here, we used male and female mice in a mouse model of paroxysmal nonkinesigenic dyskinesia (PNKD) to assess whether involuntary movements are related to aberrant activity in the striatal direct and indirect pathways. In this model, as in the human disorder PNKD, animals experience dyskinetic attacks in response to caffeine or alcohol. Using optically identified striatal single-unit recordings in freely moving PNKD mice, we found a loss of iMSN firing during dyskinesia bouts. Further, chemogenetic inhibition of iMSNs triggered dyskinetic episodes in PNKD mice. Finally, we found that these decreases in iMSN firing are likely because of aberrant endocannabinoid-mediated suppression of glutamatergic inputs. These data show that striatal iMSN dysfunction contributes to the etiology of dyskinesia in PNKD, and suggest that indirect pathway hypoactivity may be a key mechanism for the generation of involuntary movements in other disorders.SIGNIFICANCE STATEMENTInvoluntary movements, or dyskinesias, are part of many inherited and acquired neurologic syndromes. There are few effective treatments, most of which have significant side effects. Better understanding of which cells and patterns of activity cause dyskinetic movements might inform the development of new neuromodulatory treatments. In this study, we used a mouse model of an inherited human form of paroxysmal dyskinesia in combination with cell type-specific tools to monitor and manipulate striatal activity. We were able to narrow in on a specific group of neurons that causes dyskinesia in this model, and found alterations in a well-known form of plasticity in this cell type, endocannabinoid-dependent synaptic LTD. These findings point to new areas for therapeutic development.
Upper (in the pons Varolii) decussation of the motor (pyramidal) pathways and their relation to the nuclei of the pons Varolii and to the nuclei of the cranial nerves in some rodents
Authors: Korolkov Pavel Y. 
Published: February 2022

Working on the central nervous system and using the Golgi method for staining it, as early as 1896 I had the opportunity to obtain microscopic preparations on which it was easy to verify that the fibers of the motor pyramidal bundles, passing through the pons Varolii, on their way separate collateral fibers from themselves to the nuclei of the pons Varolii.
Since that time, working according to the same method, I have been able to obtain in some animals an isolated coloration of the pyramidal tracts and on such preparations to observe a partial decussation of the motor (pyramidal) tracts in the upper third of the Varolii pons, and in addition I was able to trace the collateral fibers of the motor tracts towards cranial nerve nuclei.
On the difficulty of examination in epileptic psychoses and the connection of a dream with a crime
Authors: Sergeev Leonid A. 
Published: February 2022

On November 29, 1884, the peasant Nikolai V. stabbed to death D., a worker at a potash factory rented by the merchant G. The murder, as the investigation found out, took place under the following circumstances:
On November 28, 1884, in the evening, the peasant Nikolai V. came to Fyodor N., who lived at the factory, and asked if the part of the land belonging to G., which his uncle Vasily wanted to buy, had been sold. It was late at night, Nikolai V. asked him to spend the night, which was allowed. V. went to bed in the kitchen, where the worker Dmitry P. stayed with him. There was no one in the kitchen except for the two of them. At night, Nikolai V. woke Fedor N. by knocking on the door and said that there were thieves walking around in the yard. N. jumped up, grabbed a single-barreled gun and ran out into the yard with it. Seeing no one there, he wanted to scare the thieves and fired, but there was a misfire, and he returned to the canopy. When he approached the porch of his apartment, his wife came out to meet him and gave him a revolver, and he handed her the gun. When she saw V.: and asked "what are you standing here and not going to look for thieves", he answered her "I'm afraid of something."
Maternal fetal outcome in multiple versus singleton pregnancies delivered in a teaching hospital
Authors: Sandhyasri Panda , Begum S K Reshma 
Published: February 2022

To compare the maternal and fetal outcome in multiple versus singleton pregnancies in a private teaching hospital in India. Prospectively collected data on 50 twin deliveries from July 2018 to November 2021 were studied to determine its incidence; the maternal and foetal outcome, and compared with 50 singleton deliveries conducted on same day following the twin delivery who served as controls, the twins were also analysed on the basis of chorionicity. A total of 3415 deliveries were conducted during the study period, of which 50 were twin deliveries, giving an incidence of 14 per 1000 births or 1.4:100 deliveries. Six among 50 twins resulted following ovulation induction. Women with twin gestation had a mean maternal age of 24.7±3.71, same for the singleton mothers was 24.26±3.7years; mean gestational age at delivery for twins and singletons were 35.38±2.6 and 38.63±1.19 weeks; mean birth weight for twins and singletons were 2.193kgs and 2.85±0.46kgs, mean parity were 2.04± 1.0 and 1.72±0.7 respectively. Parity, gestational age, NICU stay characteristics showed p value &#60; 0.05. Compared with singletons, women with twin gestations had a positive risk association with odds &#62;1 for anaemia, preeclampsia, preterm labour, malpresentation and caesarean delivery. Twin Neonates suffered prematurity, low birth weight, congenital anomaly, prolonged NICU care and increased perinatal death. Neonatal risk was more among monochorionic twins than dichorionic twins. There were 3 cases with single fetal demise, and both fetuses IUD in another case, (total IUDs-5), one twin was still born, two had early neonatal death and there were two late neonatal (&#62;7 Days) deaths. One twin mother threw fits on the 6th postpartum day. Another mother received 20 units of blood and component replacement and subtotal hysterectomy for PPH. Despite improvement in antenatal and neonatal care, twins pose a higher threat to MCH outcome. Hence, thorough counselling, patient awareness, more vigilance at interpretation of antenatal tests, intrapartum monitoring and bridging the gap between demand and supply at NICU facility can improve maternal and neonatal outcome; as well as can help parents cope with the psychological stress.
Clinico-histopathological spectrum of ovarian tumors in tertiary care center rajahmundry
Authors: Shaik Mahboobunnisa , Divya Singanamalla , Kadukuntla Sreeja , Annapoorna Y 
Published: February 2022

: Globally ovarian tumor is one of the leading causes of cancer death among women. It can present in childhood to postmenopausal age group and accounts for the most prevalent cause of hospital admissions. Ovarian tumor has varied histogenesis, clinical behavior and malignant potential. : This study was done to analyse the frequency of ovarian lesions, their clinico-histological features in a tertiary care center.: Retrospective hospital based study conducted in the department of Obstetrics & Gynecology, GSL medical college from December 2019 to December 2020. All the relevant clinical data of patients who were treated surgically for suspected benign lesions of ovary were analysed from hospital record ﬁle. Of the 82 cases, 63 cases: benign (51.6%), 4 cases: borderline (3.28%), 15 cases: malignant(12.3%). Serous cystadenoma is most commonly seen benign tumor. Serous cystadenocarcinoma was commonly seen malignant tumor. Younger age group primarily presented with benign tumors whereas malignant tumors were common in elderly age group. Malignant ovarian tumors most commonly seen in nulliparous. Surface epithelial tumors were the commonest ovarian tumor. Most commonly seen in the age group of 40-59yrs. Maximum numbers of malignant ovarian tumors were in the age range of &#62;50yrs.