bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in pulmonary function improvement after once-daily LABA/LAMA fixed-dose combinations in patients with COPD
Authors: Huang Wei-Chun , Chen Chih-Yu , Liao Wei-Chih , Wu Biing-Ru , Chen Wei-Chun , Tu Chih-Yen , Chen Chia-Hung , Cheng Wen-Chien 
Published: August 2022

Abstract
Objective: This real-world study evaluated the efficacy of once-daily long-acting β2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) fixed-dose combinations (FDCs) for improving spirometry in patients with chronic obstructive pulmonary disease (COPD).Methods: We conducted this retrospective study at a single medical center in Taiwan from December 2014 to September 2020. Patients with COPD who were treated with once-daily LABA/LAMA FDCs for 12 months were enrolled. We evaluated their lung function improvement after 12 months treatment with different LABA/LAMA FDCs. Results: A total of 198 patients with COPD who were treated with once-daily LABA/LAMA FDCs were analyzed. A total of 114 patients were treated with umeclidinium/vilanterol (UMEC/VIL); 34 patients were treated with indacaterol/glycopyrronium (IND/GLY) and 50 patients were treated with tiotropium/olodaterol (TIO/OLO). The forced expiratory volume in 1 second (FEV1%) was significantly increased in the patients treated with all three once-daily FDCs (55.2% to 60.9%; Δ = 5.74%, p=0.012 for UMEC/VIL, 58.2% to 63.6%; Δ = 5.37%, p=0.023 for IND/GLY, and 54.1% to 57.7%; Δ = 3.61%, p=0.009 for TIO/OLO). Treatment of COPD patients with TIO/OLO resulted in a significant improvement in both forced vital capacity (FVC%) (71.7% to 77.9%; Δ = 6.16%, p=0.009) and residual volume (RV%) (180.1% to 152.5%; Δ = -27.55%, p<0.01) compared with those treated with UMEC/VIL (FVC%: 75.1% to 81.5%; Δ = 6.45%, p < 0.001; RV%:173.8% to 165.2%; Δ = -8.67%, p=0.231) or IND/GLY (FVC%: 73.9% to 79.3%; Δ = 5.42%, p = 0.08; RV%:176.8% to 168.3%; Δ =- 8.47%, p=0.589).Conclusions: Patients with COPD who were treated with different once-daily LABA/LAMA FDCs all had pulmonary lung function improvement in FEV1. Patients treated with UMEC/VIL or TIO/OLO showed better improvement in FVC compared to those treated with IND/GLY. On the other hand, those receiving TIO/OLO had better improvement in RV compared to those who received UMEC/VIL or IND/GLY.
Learning effects in visual grading assessment of new reconstruction algorithms in abdominal Computed Tomography
Authors: Kataria Bharti , Sandborg Michael , Öman Jenny , Smedby Örjan 
Published: August 2022

Abstract
ObjectivesImages reconstructed with higher strengths of iterative reconstruction algorithms impair radiologists’ subjective perception and diagnostic performance due to changes in the amplitude of different spatial frequencies of noise. The hypothesis was that there was a change in radiologists´ assessments towards a more positive attitude to the higher strengths of Advanced modeled iterative reconstruction algorithm (ADMIRE). Can radiologists learn to adapt to the unusual appearance of images produced by higher strengths of ADMIRE?MethodsThe present study is based on two ethical board, previously published, studies that evaluated the performance of ADMIRE in non-contrast and contrast-enhanced abdominal CT. Images from 25 (first material) and 50 (second material) clinical examinations, were reconstructed with ADMIRE strengths 3, 5 and filtered back projection (FBP). These images were assessed by local radiologists using image criteria obtained from the European guidelines for quality criteria in CT. To ascertain if there was a learning effect as the reviews progressed, results from these two studies were used in the new analyses of existing data by introducing a time variable in the mixed-effects ordinal logistic regression model.ResultsFor the highest strength (5) of the ADMIRE algorithm, the significant negative attitude for both liver parenchyma and overall image quality for diagnostic purposes, at the beginning of the reviews was strengthened during the progress of the reviews in both materials. For ADMIRE strength 3, an early positive attitude for the algorithm was perceived with no significant change over time for majority of the criteria except for one criterion, i.e., the overall image quality, where a significant negative trend over time was seen in the second material. ConclusionsAs the reviews in both materials progressed, an increasing dislike for ADMIRE 5 images was apparent for at least two image criteria. In the time perspective of weeks or months, no learning effect towards accepting the new algorithm could be demonstrated.
Aloe Extracts Inhibit Skin Inflammatory Responses by Regulating NF-κB, ERK, and JNK Signaling Pathways
Authors: Wang Fei , An Quan , Wang Yiming , Yang Yang , Huo Tong , Liu Jitao , Yang Simin , Ju Ruijun , Quan Qianghua 
Published: August 2022

AbstractIntroduction: Inflammation generally refers to the body’s defensive response to stimuli, and skin inflammation is still one of the major problems that affect human physical and mental health. While current pharmacological treatments are reported to have cytotoxicity and various side effects, herbal medicines with few side effects and low cytotoxicity are considered as alternative therapeutic approaches. Methods In order to investigate anti-inflammatory effects and mechanisms of ALOE, the potential cytotoxicity ofA. veraextracts (ALOE) was determinedin vitroat first. The production of the pro-inflammatory proteins (i.e. IL-6, TNF-α) in lipopolysaccharides (LPS) and ultraviolet A (UVA)-stimulated HaCaT and RAW264.7 cells were then treated with ALOE to test its inhibitory effects using enzyme-linked immunosorbent assay (ELISA). To further explore the anti-inflammatory mechanisms of ALOE, quantitative Polymerase Chain Reaction (qPCR) was used to analyze the mRNA expression of inflammatory genesiNOS、COX-2and NO production. For NF-κB and MAPK signaling pathways analysis, western blotting and nuclear fluorescence staining were used to evaluate the expression of key factors. Results ALOE did not exhibit obvious cytotoxicity (0–3 mg/mL)in vitro. ALOE was able to inhibit the expression of pro-inflammatory cytokines IL-6, TNF-α and functioned more prominently in LPS-induced model. ALOE could also suppress the mRNA expression of LPS-inducediNOSandCOX-2and further down-regulate NO level. Furthermore, ALOE reduced the protein expression of P65 in NF-κB signaling pathway and suppressed LPS-induced activation of ERK and JNK, instead of p38 MAPK pathway. Conclusions Taken together, these results demonstrated that ALOE is a potential treatment in suppressing LPS-stimulated inflammation reactions targeting NF-κB, JNK and ERK signaling pathways. The anti-inflammatory effects of ALOE indicated that it has the potential to become an effective cosmetic ingredient.
A Hybrid topology for PV Forecasting and its application in Energy Management for Microgrid
Authors: Gupta Ankur Kumar , Singh Rishi Kumar 
Published: August 2022

Abstract
Photovoltaic (PV) system is the most promising Renewable technology. PV Forecasting is needed due to the natural variation of meteorological variables such as solar radiations and climatic conditions. Due to this the power produced by a PV system is always non-linear. A hybrid forecasting approach has been presented in this paper. This hybrid approach is a combination of statistical approach, machine learning approach as well as physical approach. The machine learning approach uses a single layer and double layer perception concept based on Artificial Neural Network (ANN) whereas the statistical and physical approach used data driven formulation concept for forecasting. This data are based on historical analysis as well as they are also helpful in future forecasting. An implementation of a two-layer hierarchical model for Energy Management System (EMS) of islanded solar Microgrid (MG) is presented. The MG control employing forecast module and simulation process has been discussed briefly. The whole forecasting has been done on the basis of real-time data (RTD) of an industry and has been simulated in HOMER student’s version software.
Intradural extramedullary tumor location in the axial view affects the alert timing of intraoperative neurophysiologic monitoring
Authors: Morito Shinji , Yamada Kei , Nakae Ichirou , Sato Kimiaki , Yokosuka Kimiaki , Yoshida Tatsuhiro , Shimazaki Takahiro , Hazemoto Yutaro , Saruwatari Rikiya , Nishida Kota , Okazaki Shingo , Hiraoka Koji 
Published: August 2022

Abstract
Objective
Intraoperative neurophysiologic monitoring (IONM) reportedly contributes to preventing postoperative neurological complications in high-risk spinal cord surgeries. There are both negative and positive reports about IONM for intradural extramedullary (IDEM) tumors. We investigated factors affecting alerts of IONM in IDEM tumor surgery.
Methods
We analyzed 39 patients with IDEM tumors who underwent surgery using IONM at our hospital between January 2014, and March 2021. Neurological symptoms were evaluated pre- and postoperatively using the manual muscle test (MMT). All patients were evaluated to ascertain the tumor level and location in the axial view, the operative time, intraoperative bleeding volume, and histological type. Additionally, the intraoperative procedure associated with significant IONM changes in transcranial electrical stimulation muscle evoked potential was investigated.
Results
There were 11 false-positive and 26 true-negative cases. There was one true-positive case and one false-negative case; the monitoring accuracy achieved a sensitivity of 50%, specificity of 70%, a positive predictive value of 8%, and a negative predictive value of 96%. In the analysis of 22 alert cases, if the tumor was located anterolateral in the axial view, alerts were triggered with a significant difference (p = 0.02) during tumor resection. Fifteen patients generated alerts during tumor resection; nine (60%) showed waveform improvement by intervention and were classified as rescue cases.
Conclusions
Alert is probably triggered during tumor resection for anterolaterally located tumors. In addition, alerts during tumor resection procedures tended to be more likely to be rescued than other procedures in IDEM tumor surgery.
Spirocamallanus delirae n. sp. (Nematoda, Camallanidae) parasite of Propimelodus eigenmanni (Siluriformes: Pimelodidae) from Brazilian Amazon Region
Authors: Ruffeil Luis Augusto Araújo dos Santos , Giese Elane Guerreiro , Pinheiro Raul Henrique da Silva 
Published: August 2022

Abstract
A new species of Camallanidae was found parasitizing Amazonian fish. The new species of Spirocamallanus Olsen 1952 has a mouth capsule armed with 15-19 spirals, a pre-equatorial vulva, and the presence of a digitiform projection with two small terminal cuticular spines on the tail of the female, while the tail of the male is conical, with the presence of a caudal wing and a tip with two small terminal cuticular spines. Morphologically, the new species shares features with S. pereirai, S. macaensis, S. cruzi and S. halithophus, which are parasites of marine fishes. However, it differs from the new species in spicule morphology, distribution and number of caudal papillae in males, and host environment (freshwater). The new species is added to the fish parasite biodiversity of the Brazilian Amazon.
Transboundary cooperation in infrastructure operation generates economic and environmental co-benefits to the Lancang-Mekong River Basin
Authors: Yu Yang , Bo Yan , Castelletti Andrea , Dumas Patrice , Gao Jinyu , Cai Ximing , Liu Junguo , Kahil Taher , Wada Yoshihide , Liu Bo , Zhou Feng , Zhao Jianshi 
Published: August 2022

Abstract

The Lancang-Mekong River basin (LMRB) is facing blooming water resources infrastructure development, long-term transboundary conflicts and trade-offs between economic goals and ecosystem services provision. Yet, most studies optimizing the pathway towards sustainable infrastructure operation have lacked multi-sectoral and cross-country perspectives. Here, we quantify how and to what extent transboundary cooperation generate economic and environmental co-benefits by jointly using a coupled simulation-optimization approach and cooperative game theoretical analysis. We find that cooperation outweighs non- or partial cooperation modes to promote economic benefits by 5 to 27%, and to minimize the losses in fishery and sediment transport from 14% and 33% to 8% and 10%, respectively. Full cooperation becomes more stable alongside infrastructure expansion, climate change, and the degree of satisfying hydrological needs for river ecosystems. These findings underscore the importance of full cooperation for sustaining socio-environmental systems and suggest the needs of benefit reallocation mechanism and designed flow management for stabilizing basin-level full cooperation in the LMRB.
Association between Pneumothorax and Deaths among Damascus Hospital Patients
Authors: Baranbo Saleh , Baranbo Aya , Al-Bardan Hussam 
Published: August 2022

AbstractBackground Pneumothorax is a major source of morbidity and mortality in Syria, although there is little information on the etiology, clinical profile, therapy, and outcome of pneumothorax in recent years. Method The patients in this retrospective observational study with the diagnosis of pneumothorax were seen over the course of a year at Damascus hospital. From hospital records, demographic, clinical, radiological, and therapeutic information were gathered and analysed. Results Out of 112 patients, 90.2% were male and 9.8% were females, with the majority, 23.2%, falling between the ages of 20 and 30. 65.2% of the patients were smokers. Patients had spontaneous pneumothorax 58%, secondary pneumothorax 23.2%, tension pneumothorax 7.1%, traumatic pneumothorax 6.3%, and recurrent pneumothorax 5.4%. The pneumothorax was in the right side in 29.5% of patients, in the left side in 25.9%, and bilaterally in 5.4%. Furthermore, 72.7% of patients with secondary pneumothorax died. Patients with bilateral pneumothorax were the most likely to die (66.7%). 93.9% of patients healed significantly after having a chest drainage placed on them. Conclusion Our findings indicate that pneumothorax is more common in men. Primary spontaneous pneumothorax is more common than secondary pneumothorax, and pneumonia and COPD were the most common causes of secondary pneumothorax, followed by Muti organ failure.
Combined effect of inhomogeneous strain-induced and anisotropy on friction in deep drawing of DC06EK sheet metal
Authors: BELGUEBLI Amina , ZIDANE Ibrahim , MENDAS Mohammed , MADAOUI Zakarya , BENHAMOU Abdessoufi 
Published: August 2022

Abstract
The aim of this work is to simultaneously evaluate the effects of inhomogeneous strain-induced and anisotropy on the friction during the deep drawing of DC06EK sheet metal. To do that, stretched and unstretched DC06EK strips in different rolling directions (0°, 45° and 90°) with different levels of equivalent plastic strain were used in microscratch tests under the same conditions as those used in deep drawing process (DDP) coming from a local industry. The findings show that the coefficient of friction (COF) decreases as a function of the equivalent plastic strain for different rolling directions. Two empirical friction laws are obtained depending on the equivalent plastic strain following 0° and 90° to the rolling direction. Since the COF have a clear trend of regression except in the case for 45°. Trend lines of the COF following 0° and 90° converge to very closely values, since the effect of anisotropy disappears with the increase in the level of plastic strain.
Outbreak News Affects the Attention in Everyday Life: A Cross-sectional Study
Authors: Kheirkhah Mohammad Taghi , Moazzen Hamze , Mirchi Zahra , Nezamolslami Atefeh , Kord Moslem , Mokarami Mehran , Gharibzadeh Shahriar , Saffarinia Majid 
Published: August 2022

Abstract
Objective: Capture of attention occurs when a goal-irrelevant salient stimulus appears in the field of attention. The COVID-19 pandemic seems to be salient enough to capture a great proportion of one’s attentional resources. The purpose of this study was to explore how the novelty of outbreak news affects attention in everyday life. Methods: 162 participants were recruited using an online invitation and divided into two samples (early and late sections). The variables—salience of news, intrusive thoughts, endogenous attention, and knowledge of COVID-19—have compared between two measurements using independent t-tests. Additionally, a correlational analysis was performed in order to reveal a model of relationships between variables. Results: It was found that despite the increase in infected cases, intrusive thoughts and attentional capture have decreased over time. To describe the relationship between salience of news and attentional capture a conceptual model is presented. Conclusion: In addition to the other physical properties of a stimulus, novelty also contributes to stimulus salience. In everyday life, novel situations can trigger intrusive thoughts and attentional capture. Nonetheless, it cannot be sustained after the novelty has worn off. The proposed model can be useful to understand further similar situations.
PERMODELAN POROSITAS TANAH BERBASIS FUZZY UNTUK PENDUKUNG SERIOUS GAME PENGOLAHAN TANAH
Authors: Gunawan Agung Hendra 
Published: August 2022

Pada pembuatan serious game bertemakan bajak singkal banyak faktor pendukung untuk memenuhi tujuan sebagai sarana pelatihan. sehingga dapat menampilkan gambaran keadaan senyata mungkin pada saat menjalankannya. Salah satunya porositas tanah, dalam jurnal ini mejelaskan perhitungan porositas tanah menggunakan fuzzy logic. Fuzzy logic sendiri Metode ini dipilih karena sifatnya yang fleksibel, dan memiliki toleransi pada data yang ada. Kelebihan dari metode ini yaitu lebih cepat dalam melakukan komputasi, lebih intuitif, diterima oleh banyak pihak. Oleh karena itu, model tersebut dapat digunakan untuk merancang game serius yang nyata berdasarkan teori dan data
Hydrogeochemical assessment of streamwater quality for its suitability for irrigation: the case of Manthong village, Kanglung (Bhutan)
Authors: Dendup Tshewang , Lekzin Pema , Lhendup Tshewang , Tobgay Sonam 
Published: August 2022

Abstract
Mountain streams/springs are the primary irrigation water resource in Bhutan Himalaya, besides supporting drinking and other domestic needs. Successful crop production implies an adequate supply of high-quality irrigation water, among other factors. Thus, this study was conducted to assess the suitability of spring-fed streamwater for irrigation use and evaluate hydrogeochemical processes that regulate streamwater chemistry at the Manthong village in Kanglung, Bhutan. The water samples were analyzed for temperature, pH, electrical conductivity (EC), turbidity, total dissolved solute (TDS) and major ions. Piper and Durov diagrams indicated that most samples are of the intermediate type and simple dissolution or linear mixing is the primary hydrochemical process regulating streamwater chemistry. All the measured physicochemical parameters were within the acceptable thresholds of the FAO guidelines recommended for agricultural use. Analytical results of the streamwater water quality indices, including EC, %Na, residual sodium bicarbonate (RSBC), sodium adsorption ratio (SAR), Kelley's ratio (KR) and permeability index (PI), revealed its suitability for irrigation use except for magnesium hazard (MH). The Irrigation Water Quality Index (IWQI) results confirmed that the WS-1 has no restriction as irrigation water; however, WS-2 falls under the high-restriction category. The findings of this study will serve as the baseline data and guide irrigation water management and sustainable irrigation development in the region.
PbO2 modified BDD electrode by dicationic ionic liquids assisted electrodeposition for efficient electrocatalytic degradation of pesticide wastewater
Authors: Tang Yining , Feng Shangce , He Deliang 
Published: August 2022

Abstract
Pesticide wastewater is difficult to treat, and it is necessary to develop a new anode material electrochemical oxidation to efficiently degrade pesticide wastewater. DIL-PbO2-Ti/BDD electrodes with better electrocatalytic oxidation performance were obtained by using dicationic ionic liquid (DIL) for assisted electrodeposition of PbO2 modified boron-doped diamond (BDD) electrodes. At a current density of 100 mA cm−2 and a temperature of 25 °C, the DIL-PbO2-Ti/BDD electrode was used as anode and titanium plate as cathode. The electrochemical window and oxygen evolution potential (OEP) of the DIL-PbO2-Ti/BDD electrode obtained by CV testing at a scan rate of 50 mV s−1 in 1 M H2SO4 were 4.12 and 3.29 V, respectively. Under the conditions of current density of 100 mA cm−2, 25 °C, pH 12, salt content of 8%, chemical oxygen demand (COD) of 24,280.98 mg L−1, and total nitrogen (TN) content of 5268 mg L−1, after electrification for 12 h, the removal efficiency of COD and TN reached 64.88 and 67.77%, respectively, indicating that the DIL-PbO2-Ti/BDD electrode has excellent electrocatalytic performance. In order to further understand the mechanism of electrochemical degradation of pesticide wastewater, HPLC-MS was used to detect the intermediates in the degradation process, and the possible degradation pathways were proposed in turn.
How to physical fitness intellectual disability by nutritional status during the pandemic?
Authors: Burhaein Erick , Irfatoni Irfatoni , Rozak Romy Abdul , Kusmiati Lili , Setiabudi Agus , LourenÇo Carla Cristina Vieira , Basit Miftah Muhammad 
Published: August 2022

The aim of the study was to look at students' physical fitness conditions based on nutritional status (BMI) during the COVID-19 pandemic. The participants of this study were 24 deaf students. This research instrument is a test of height and weight that has been standardized. Data analysis uses quantitative descriptive statistics. Divided into two, the first in male students (Pi) is the category as thin as 1 student (7.14%), ideal low as many as 4 students (28.57), ideal as many as 3 students (21.43%), ideal height as many as 5 students (35.71%), and very fat as many as 1 student (7.14%). Most of this Pa data is in the ideal category with M= 20.68. Female Students (Pi) is a skinny category of 1 student (7.14%), ideal as many as 10 students (71.43%), fat as many as 2 students (14.29%), and obesity as many as 1 student (7.14%). Most of this Pi data is in the ideal category with M= 22.46. The conclusion of this study is to provide recommendations on future studies that the need to include certain free variables to be known to be dominant variables in influencing nutritional status in children.