bluuebunny/crossref_metadata_2025_split huggingface dataset:
An unusual ileocecal tumor
Authors: Inoue Takato , Inoue Naonori , Kawamura Takuji , Uno Koji 
Published: September 2022

ABSTRACT
We report the case of diffuse large B-cell lymphoma (DLBCL) with a fistula from the ileum to the cecum. A 57-year-old male came to the hospital complaining of abdominal pain. He underwent an abdominal computed tomography with contrast, which showed full-thickness wall thickening at the ileocecal region. He underwent a lower gastrointestinal endoscopy. No tumor was found at the ileocecal valve, and macroscopic findings were normal. The scope was advanced to the cecum, an additional outpouching was found. The outpouching appeared to be an ileocecal fistula. The diagnosis was DLBCL.
Shortened chordae tendineae of the tricuspid valve with right ventricular dysfunction caused by acute myocarditis lead to cardiogenic shock during pericardial drainage: a case report
Authors: Higuchi Motoaki , Mitomi Kisato , Chiba Yoshiro 
Published: September 2022

ABSTRACT
A 63-year-old woman was admitted to the hospital with general malaise and pericardial and thoracoabdominal effusions of unknown cause. After pericardial drainage for drug-resistant right heart failure, she developed right ventricular (RV) dysfunction and cardiogenic shock caused by severe tricuspid regurgitation (TR). Findings during emergency surgery included tricuspid valve (TV) junction failure caused by shortening of the chordae tendineae of the TV, which is an organic abnormality. Additionally, myocardial biopsy results revealed myocarditis. Although acute myocarditis developed with RV dysfunction, pericardial effusion suppressed venous return, which temporarily improved her pathological condition. However, RV dysfunction and severe TR were thought to have manifested after the venous return suppression was alleviated by pericardial drainage. Because venous return changes significantly after pericardial drainage, it is necessary to examine the need for drainage and re-evaluate the post-operative RV system.
Urethral metastasis from esophageal cancer: symptoms of dysuria and cystoscopic diagnosis
Authors: Kitashiro Saya , Kuno Ikumi , Sugano Tenyu , Yamano Yukimasa , Shigeoka Yasushi , Inaba Mayumi 
Published: September 2022

ABSTRACT
Urethral malignant tumors are rare and can lead to stenosis, causing dysuria. We report a case of urethral metastasis secondary to esophageal cancer. At the time of diagnosis, a patient with esophageal squamous cell carcinoma presented with voiding difficulties, feeble stream, terminal dribbling and incomplete voiding. The urethral tumor was diagnosed using cystoscopy, and biopsy was thereafter performed. Histopathology of the urethral tumor microscopically resembled to that of esophageal cancer. On immunohistochemistry, the urothelium markers uroplakin 2 and GATA3 were negative in the carcinomatous component; however, GATA3 was detected on the lesion’s surface. This case demonstrated that esophageal cancer metastasized to the urethra. Medical oncologists should consider this diagnosis in patients with cancer presenting with dysuria.
Long Covid brain fog: a neuroinflammation phenomenon?
Authors: Kavanagh Emma 
Published: September 2022

Abstract
Neuroinflammation is a process triggered by an attack on the immune system. Activation of microglia in response to an immune system challenge can lead to a significant impact on cognitive processes, such as learning, memory and emotional regulation. Long Covid is an ongoing problem, affecting an estimated 1.3 million people within the UK alone, and one of its more significant, and as yet unexplained, symptoms is brain fog. Here, we discuss the potential role of neuroinflammation in Long Covid cognitive difficulties. Inflammatory cytokines have been found to play a significant role in reductions in LTP and LTD, a reduction in neurogenesis, and in dendritic sprouting. The potential behavioural consequences of such impacts are discussed. It is hoped that this article will allow for greater examination of the effects of inflammatory factors on brain function, most particularly in terms of their role in chronic conditions.
An anisotropic negative thermal expansion metamaterial with sign-toggling and sign-programmable Poisson’s ratio
Authors: Lim Teik-Cheng 
Published: September 2022

AbstractObjectivesA mechanical metamaterial is introduced herein by drawing inspiration from an Aztec geometric pattern. This metamaterial deformation mechanism for Poisson’s ratio and Young’s modulus is based on non-rotating rhombi with rotating triangles, while the shear modulus analysis herein is based on rotating rhombi with non-rotating triangles, hence ‘partially rotating rigid units’.MethodsThe coefficient of thermal expansion was obtained by equating the potential energy expressions from the simple harmonic motion and from the principle of energy equipartition, while the effective-moduli were acquired by equating the strain energy from rotational stiffness with that from the strain energy of deformation based on an assumed homogenized continuum. Due to the zero and extreme Poisson’s ratio based on infinitesimal deformation, the finite approach was employed.ResultsResults indicate that the proposed metamaterial exhibits anisotropic negative thermal expansion with sign-switching Poisson’s ratio when applied stress along one axis is reversed. The Poisson’s ratio for loading in another axis is undefined under tension but can be programmed to exhibit either sign when compressed. The Young’s and shear moduli are directly governed by the rotational stiffness and strongly influenced by the extent of rotation, followed by the aspect ratio of the rotating units.ConclusionDue to its uniqueness, the currently considered mechanical metamaterial can be used under specific requirements which are difficult to be attained by other materials with negative properties.
In vivo Imaging Enables Understanding of Seamless Plant Defense Responses to Wounding and Pathogen Attack
Authors: Toyota Masatsugu , Betsuyaku Shigeyuki 
Published: September 2022

Abstract
Plants are exposed to varied biotic stresses, including sequential or simultaneous attack by insects and pathogens. To overcome these complex stresses, plants must perceive each of the stresses, then integrate and relay the information throughout the plant body and eventually activate local and systemic resistance responses. Previous molecular genetic studies identified jasmonic acid and salicylic acid as key plant hormones of wound and immune responses. These hormones, combined with their antagonistic interaction, play critical roles in the initiation and regulation of defense responses against insects and pathogens. Aside from molecular and genetic information, the latest in vivo imaging technology has revealed that plant defense responses are regulated spatially and temporally. In this review, we summarize the current knowledge of local and systemic defense responses against wounding and diseases with a focus on past and recent advances in imaging technologies. We discuss how imaging-based multiparametric analysis has improved our understanding of the spatiotemporal regulation of dynamic plant stress responses. We also emphasize the importance of compiling the knowledge generated from individual studies on plant wounding and immune responses for a more seamless understanding of plant defense responses in the natural environment.
The Effect of Local Anesthetics and Contrast Agents on Radiofrequency Ablation Lesion Size
Authors: Ortiz Nicole , Shahgholi Leili , Kohan Lynn , Wahezi Sayed E 
Published: September 2022

AbstractBackgroundRadiofrequency ablation (RFA) is a validated treatment option for the treatment of chronic pain in patients with lumbar spondylosis. Lesion size has been suggested to correlate with good clinical outcomes. This has created an abundance of scientific interest in the development of products with larger lesion characteristics. Needle characteristics, energy transfer, and heat rate are known to modify lesion size. Here, we demonstrate that common intraoperative solutions, such as lidocaine, iodine, and gadolinium-based products, can also affect lesion shape.ObjectivesTo determine whether lidocaine and contrast agents modify lesion characteristics during the performance of monopolar RFA.Study designControlled, ex vivo study using clinically relevant conditions and pre-injections.SettingAcademic institution in a procedural setting.MethodsRFA lesion size was compared among six cohorts: 1) lidocaine 1%, 2) lidocaine 2%, 3) iohexol 180, 4) iohexol 240, 5) gadodiamide, and 6) control (no fluid control). Radiofrequency (RF) current was applied for 90 seconds at 80°C via 20-gauge 100-mm standard RFA needles with 10-mm active tips in orgranic chicken breasts without preservative at room temperature (21°C). Twelve lesions were performed for each medication cohort. The length, width, and depth of each lesion were measured. The statistical significance between each medication group and the control group was evaluated by t test.ResultsThe mean lesion surface area of monopolar RFA without any pre-injection used was 80.8 mm2. The mean surface area of the monopolar RF lesion with a pre-injection of 0.2 mL of 2% lidocaine was 114 mm2, and the mean surface area of the monopolar RF lesion with a pre-injection of 0.2 mL of iohexol 240 was 130.6 mm2. The statistical analysis demonstrated that the control group had significantly smaller lesion sizes than did the groups in which lidocaine 2% and iohexol 240 were used (P&lt;0.01). There were no statistically significant differences among the groups in which lidocaine 1%, iohexol 180, and gadodiamide were used. A notable difference was a 20% longer lesion with iohexol 240 compared with the control group and a 20% wider lesion with lidocaine 2% compared with the control group.LimitationsIn vivo anatomy within a human was not used in this study, nor were the chicken breasts heated to physiological temperature. Randomization of pieces of chicken breast did not occur, and thus intrinsic differences among the chicken breast pieces could play a confounding role.ConclusionsLidocaine 2% and iohexol 240, when used as pre-injections in RFAs, were found to be associated with statistically significant increases in lesion surface area. However, RFAs with lidocaine 1%, iohexol 180, or gadodiamide were not found to produce a statistically significant difference in lesion size compared with monopolar RFA without the use of injectate.
Does Online Professional Development for Physical Therapists Enhance Clinical Practice and Patient Outcomes? Protocol for a Mixed Methods, Randomized Controlled Trial
Authors: Leahy Edmund , Chipchase Lucy , Blackstock Felicity C 
Published: September 2022

Abstract

Objective
Online clinical mentoring has shown potential as a flexible professional development activity that enhances physical therapist practice. Online delivery can overcome time and distance barriers to participation in professional development. The impact of this learning activity on physical therapist practice and patient outcomes has not been rigorously tested. Thus, the aim of this study is to determine whether online clinical mentoring is more effective than asynchronous online lectures at improving physical therapist practice and patient outcomes. An additional aim is to explore the lived experience of physical therapist learners who participate in online clinical mentoring.

Methods
In this mixed methods evaluation, 24 physical therapist learners will be randomized to 1 of 2 online professional development activities. Experimental group physical therapists will complete 6 online clinical mentoring sessions. Control group physical therapists will complete 6 online lectures. The primary outcome evaluated will be the effect on the physical therapist’s patients, using the Patient-Specific Functional Scale. Physical therapist learner secondary outcomes are confidence, self-reflection, and satisfaction. Accounting for possible dropouts, a sample size of 216 patients was determined using a pragmatic sample of 24 physical therapists, power of 0.80, alpha of 0.05, and between-group differences of 1.0 (SD = 2.0) on the Patient-Specific Functional Scale. Consecutive, eligible patients under the care of the physical therapist learners will complete outcome measures at initial appointment and at 4 weeks follow-up. Linear mixed model regression analysis will be used to estimate treatment effects from the posttreatment group means at 4 weeks. Participants undertaking online clinical mentoring will complete semi-structured interviews that will be thematically analyzed using a phenomenological approach.

Impact
This research study will establish the effectiveness of online clinical mentoring to inform future professional development. The qualitative component will identify the potential mechanisms by which online clinical mentoring might be effective, thus informing future implementation of this professional development activity.
Sirenaicks, Guilds and a New Coryate Manuscript
Authors: Neuhauser Julian T S 
Published: September 2022

Abstract
While Thomas Coryate (1577–1617) is most often remembered as an eccentric and pioneering travel writer, his other claim to fame is his participation in a group called ‘right Worshipful Fraternitie of Sireniacal Gentlemen’. Often conflated with the ‘Mermaid Club’, this group met monthly at the Mermaid Tavern to eat, drink and trade jesting verses. Coryate’s role in the group was often that of the comic butt, a position that had classical antecedents in the buffoonish roles of the parasite at Greek symposia and the scurra at Roman convivia. However, a previously overlooked manuscript suggests that Coryate had a closer relationship to at least one of the other Sireniacal Gentlemen, John Hoskins, than simply being his club’s object of ridicule. This new evidence prompts a re-examination of the primary sources related to the ‘Sirenaicks’ (as Coryate called them) as well as the scholarship scrutinizing that group. This essay argues that the Sirenaicks organised themselves as a mock-guild and it begins to develop an understanding of how that social structure affected the group’s mode of literary production.
Development of prediction models to select older RA patients with comorbidities for treatment with chronic low-dose glucocorticoids
Authors: Hartman Linda , da Silva José A P , Buttgereit Frank , Cutolo Maurizio , Opris-Belinski Daniela , Szekanecz Zoltan , Masaryk Pavol , Voshaar Marieke J H , Heymans Martijn W , Lems Willem F , van der Heijde Désirée M F M , Boers Maarten 
Published: September 2022

Abstract

Objective
To develop prediction models for individual patient harm and benefit outcomes in elderly patients with RA and comorbidities treated with chronic low-dose glucocorticoid therapy or placebo.

Methods
In the Glucocorticoid Low-dose Outcome in Rheumatoid Arthritis (GLORIA) study, 451 RA patients ≥65 years of age were randomized to 2 years 5 mg/day prednisolone or placebo. Eight prediction models were developed from the dataset in a stepwise procedure based on prior knowledge. The first set of four models disregarded study treatment and examined general predictive factors. The second set of four models was similar but examined the additional role of low-dose prednisolone. In each set, two models focused on harm [the occurrence of one or more adverse events of special interest (AESIs) and the number of AESIs per year) and two on benefit (early clinical response/disease activity and a lack of joint damage progression). Linear and logistic multivariable regression methods with backward selection were used to develop the models. The final models were assessed and internally validated with bootstrapping techniques.

Results
A few variables were slightly predictive for one of the outcomes in the models, but none were of immediate clinical value. The quality of the prediction models was sufficient and the performance was low to moderate (explained variance 12–15%, area under the curve 0.67–0.69).

Conclusion
Baseline factors are not helpful in selecting elderly RA patients for treatment with low-dose prednisolone given their low power to predict the chance of benefit or harm.

Trial registration
https://clinicaltrials.gov; NCT02585258.
A novel long non-coding RNA, lnc-RNU12, influences the T-cell cycle via c-JUN and CCNL2 in rheumatoid arthritis
Authors: Mo Xing-Bo , Sun Yang-Hua , Wu Long-Fei , He Pei , Cao Rong-Rong , Lu Xin , Zhang Yong-Hong , Deng Fei-Yan , Lei Shu-Feng 
Published: September 2022

Abstract

Objectives
Long non-coding RNAs (lncRNAs) play important roles in RA pathogenesis. However, specific lncRNAs that regulate gene expression in RA pathogenesis are poorly known. This study was undertaken to characterize a novel lncRNA (lnc-RNU12) that has a lower-than-normal expression level in RA patients.

Methods
We performed initial genome-wide lncRNA microarray screening in peripheral blood mononuclear cells from 28 RA cases and 18 controls. Multiple methods were used to validate the detected associations between lncRNAs and RA. Furthermore, we identified the source and characteristics of the highlighted lncRNAs, detected the target genes, and determined the functional effect on immune cells through lncRNA knock-down in Jurkat T cell lines.

Results
lnc-RNU12 was downregulated in peripheral blood mononuclear cells and T cell subtypes of RA patients and was genetically associated with RA risk. lnc-RNU12 mediates the effect of microbiome alterations on RA risk. Activation of T cells caused low expression of lnc-RNU12. Knock-down of lnc-RNU12 in Jurkat T cells caused cell cycle S-phase arrest and altered the expression of protein-coding genes related to the cell cycle and apoptosis (e.g. c-JUN, CCNL2, CDK6, MYC, RNF40, PKM, VPS35, DNAJB6 and FLCN). Finally, c-JUN and CCNL2 were identified as target genes of lnc-RNU12 at the mRNA and protein expression levels. RNA-binding protein immunoprecipitation assays verified the interaction between lnc-RNU12 and the two proteins (c-Jun and cyclin L2) in Jurkat cells.

Conclusions
Our study suggested that lnc-RNU12 was involved in the pathogenesis of RA by influencing the T cell cycle by targeting c-JUN and CCNL2.
Precious Neighbors: The Value of Co-Locating with the Government
Authors: Stahl Jörg R 
Published: September 2022

Abstract
In many countries, disproportionately many firms locate their headquarters in the capital city. Spatial proximity to a country’s leading politicians may be beneficial for a number of reasons. Since neither firms nor governments move randomly, the effects of firms’ co-locating with the government are normally hard to identify. I solve this problem by examining a unique event—the decision to relocate the German federal government from Bonn to Berlin in 1991. Following reunification, there was a free vote in the German parliament on the future location of the government. Berlin won by a narrow margin, an event that could not be anticipated even days before and that is free from confounding factors. Firms with corporate headquarters in Berlin experience abnormal equity returns of more than 3% following the relocation decision.
Using the Health Belief Model to improve influenza vaccination rates
Authors: Gutierrez Felicia , Wolfe Justin 
Published: September 2022

ABSTRACT
Vaccination rates for influenza are lower than expected each year in the United States. Multiple factors contribute to low vaccination rates, including poor access to healthcare, lack of insurance, and patient perception of risk and benefit. A better working understanding of the Health Belief Model can help clinicians understand the psychologic factors that contribute to low vaccination rates and help clinicians improve patient understanding and uptake of the influenza vaccine.
Allergen immunotherapy, cancer, and immune disorders
Authors: El-Qutob David , Matheu Victor , Fernandez-Caldas Enrique 
Published: September 2022

Purpose of review
The purpose of this review is to provide an update on the intriguing relationships between allergies, allergen immunotherapy, cancer, and immune disorders. Allergic diseases and cancer are increasing in incidence and prevalence and a potential relationship, or not, between these diseases have been suggested for many years.

Recent findings
Recent findings suggest that there may be some causative effects between certain types of cancer and allergic diseases, as described in the text. Some types of cancer may be more linked to the presence of an allergic disease, than others. However, epigenetic factors, such as tobacco smoke alcohol and toxic substances should also be taken into consideration.

Summary
The association between allergy and cancer is complex and depends on the specific allergy and the specific organ under consideration. Regarding pancreatic cancer, colorectal cancer (CRC), and glioma, all types of allergies were shown to be a protective factor. Conversely, asthma is a risk factor for lung cancer as is atopic dermatitis for skin cancer. Despite extensive research, no definite relationship has been determined, and no clear relationship, either positive or negative, to allergies can be observed. These results should be corroborated with large epidemiological well designed prospective studies due to some weaknesses in the previous investigations.
Longitudinal Development of Verbal and Nonverbal Intelligence After Cochlear Implantation According to Wechsler Tests in German-speaking Children: A Preliminary Study
Authors: Fei Peipei , Shehata-Dieler Wafaa , Huestegge Lynn , Hagen Rudolf , Kühn Heike 
Published: September 2022

Objectives:
Intelligence as a construct of cognitive abilities is the basis of knowledge and skill acquisition and the main predictor of academic achievement. As a broad construct, it is usually divided into subdomains, such as nonverbal and verbal intelligence. Verbal intelligence is one domain of intelligence but is not synonymous with specific linguistic abilities like grammar proficiency. We aim to address the general expectation that early cochlear implantation enables children who are hard of hearing to develop comprehensively, including with respect to verbal intelligence. The primary purpose of this study is to trace the longitudinal development of verbal and nonverbal intelligence in children with cochlear implants (CIs).

Design:
Sixteen children with congenital hearing loss who received unilateral or bilateral implants and completed at least two intelligence assessments around the age of school entrance were included in the study. The first assessment was performed around 3 years after CI fitting (chronological age range: 3.93 to 7.03 years). The second assessment was performed approximately 2 years after the first assessment. To analyze verbal and nonverbal IQ in conjunction and across children at different ages, we used corresponding standardized and normalized tests from the same test family (Wechsler Preschool and Primary Scale of Intelligence and/or Wechsler Intelligence Scale for Children).

Results:
Regarding longitudinal development, both verbal and nonverbal IQ increased, but verbal IQ increased more substantially over time. At the time of the second measurement, verbal and nonverbal IQ were on a comparable level. Nevertheless, we also observed strong inter-individual differences. The duration between both assessments was significantly associated with verbal IQ at the second measurement time point and thus with verbal IQ gain over time. Education mode (regular vs. special kindergarten/school) was significantly correlated with nonverbal IQ at the second assessment time point.

Conclusions:
The results, despite the small sample size, clearly suggest that children with CIs can achieve intellectual abilities comparable to those of their normal-hearing peers by around the third year after initial CI fitting, and they continue to improve over the following 2 years. We recommend further research focusing on verbal IQ assessed around the age of school entrance to be used as a predictor for further development and for the establishment of an individual educational program.