bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of third wave cognitive behavioural therapies for children and adolescents: A systematic review and meta‐analysis
Authors: Perkins Amorette M. , Meiser‐Stedman Richard , Spaul Samuel W. , Bowers Gemma , Perkins Abigail G. , Pass Laura 
Published: November 2022

AbstractObjectivesThird wave cognitive behavioural therapies are increasingly used with children and adolescents. This meta‐analysis aimed to determine the effectiveness of four third‐wave interventions (acceptance and commitment therapy, compassion focused therapy, mindfulness‐based cognitive therapy, and metacognitive therapy) for youth.MethodsFour electronic databases were used to identify randomized controlled trials, which tested effects related to health, well‐being and functioning. Sensitivity analyses considering study quality were conducted and moderators were explored.ResultsThe results based on 50 RCTs meeting inclusion criteria indicated emotional symptoms/internalizing problems (g = −.68, 95% CI −.98 to −.37, k = 43, N = 3265), behavioural difficulties/externalizing problems (g = −.62, 95% CI −1.01 to −.22, k = 23, N = 1659), interference from difficulties (g = −.46, 95% CI −.87 to −.05, k = 21, N = 1786), third wave processes (g = .39, 95% CI .17 to .62, k = 22, N = 1900), wellbeing/flourishing (g = .76, 95% CI .35 to 1.17, k = 21, N = 1303) and physical health/pain (g = .72, 95% CI .01 to 1.44, k = 9, N = 1171) yielded significant effects. Effect for quality of life (g = .62, 95% CI −.08 to 1.31, k = 12, N = 1271) was non‐significant. When analysing only those studies rated moderate‐high quality, third wave interventions yielded significant superiority effects compared to controls for emotional symptoms/internalizing problems (g = −.55, 95% CI −.82 to −.27, k = 28, N = 2110), interference from difficulties (g = −.48, 95% CI −.90 to −.05, k = 21, N = 1605), third wave processes (g = .27, 95% CI .11 to .43, k = 18, N = 1692), well‐being/flourishing (g = .50, 95% CI .18 to .81, k = 16, N = 1063), and quality of life (g = .32, 95% CI .04 to .60, k = 10, N = 1212). Behavioural difficulties/externalizing problems (g = −.38, 95% CI −.86 to .10, k = 15, N = 1351) and physical health/pain (g = .52, 95% CI −.14 to 1.17, k = 8, N = 1139) ceased to be significant. Widespread heterogeneity raised concerns about generalizability and follow‐up data was relatively sparse.ConclusionsThis meta‐analysis finds promising results for use of third wave CBT with youth, though the review has limitations.
Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents
Authors: Chen Li‐Qiang , Lv Xue‐Jing , Guo Qing‐Huan , Lv Su‐Su , Lv Ning , Xu Wen‐Dong , Yu Jin , Zhang Yu‐Qiu 
Published: November 2022

Background and PurposePatients suffering from trigeminal neuralgia are often accompanied by anxiety and depression. Microglia‐mediated neuroinflammation is involved in the development of neuropathic pain and anxiodepression pathogenesis. Whether and how microglia are involved in trigeminal neuralgia‐induced anxiodepression remains unclear.Experimental ApproachUnilateral constriction of the infraorbital nerve (CION) was performed to establish trigeminal neuralgia in rat and mouse models. Mechanical allodynia and anxiodepressive‐like behaviours were measured. Optogenetic and pharmacological manipulations were employed to investigate the role of hippocampal microglia in anxiety and depression caused by trigeminal neuralgia.Key ResultsTrigeminal neuralgia activated ipsilateral but not contralateral hippocampal microglia, up‐regulated ipsilateral hippocampal ATP and interleukin‐1β (IL‐1β) levels, impaired ipsilateral hippocampal long‐term potentiation (LTP) and induced anxiodepressive‐like behaviours in a time‐dependent manner in rodents. Pharmacological or optogenetic inhibition of ipsilateral hippocampal microglia completely blocked trigeminal neuralgia‐induced anxiodepressive‐like behaviours. Activation of unilateral hippocampal microglia directly elicited an anxiodepressive state and impaired hippocampal LTP. Knockdown of ipsilateral hippocampal P2X7 receptors prevented trigeminal neuralgia‐induced microglial activation and anxiodepressive‐like behaviours. Furthermore, we demonstrated that microglia‐derived IL‐1β mediated microglial activation‐induced anxiodepressive‐like behaviours and LTP impairment.Conclusion and ImplicationsThese findings suggest that priming of microglia with ATP/P2X7 receptors in the ipsilateral hippocampus drives pain‐related anxiodepressive‐like behaviours via IL‐1β. An asymmetric role of the bilateral hippocampus in trigeminal neuralgia‐induced anxiety and depression was uncovered. The approaches targeting microglia and P2X7 signalling might offer novel therapies for trigeminal neuralgia‐related anxiety and depressive disorder.
Translation, cross‐cultural adaptation, validity and reliability of the Brazilian Portuguese version of Activity Scale for Kids questionnaire
Authors: de Oliveira Vanessa Gonçalves Coutinho , Balau Laura Cardoso , Arrebola Lucas Simões , Young Nancy Lynn , Yi Liu Chiao 
Published: November 2022

AbstractBackgroundThe Activity Scale for Kids (ASK) assesses the physical disability of children (5 to 15 years old) with neurological, orthopaedic or rheumatic diseases. The objective of this study was to translate and cross‐culturally adapt the ASK for Brazilian Portuguese and assess the validity and reliability of the instrument.MethodsA total of 67 children and adolescents with musculoskeletal, neurological or rheumatic diseases participated in the study. We evaluated the comprehension of the pre‐final version of the questionnaire in 24 participants and reliability and validity in the other 43 participants. The translation and adaptation of ASK to Brazilian Portuguese followed guidelines from previous studies. The validity of the Brazilian Portuguese version of the ASK was verified through Spearman's correlation with the Pediatric Quality of Life Inventory™ Version 4.0 (PedQL). Intraclass correlation coefficient verified inter‐ and intra‐evaluator reliability, while internal consistency was assessed using Cronbach's alpha. Scores were used to assess the standard error of the mean and minimal detectable change.ResultsThe Brazilian Portuguese version of the ASK presented excellent reliability, internal consistency, agreement and moderate correlation with PedsQL (0.522, P < 0.001) between ASK performance and PedsQL; 0.537, P < 0.001 between ASK capacity and PedsQL.ConclusionThe Brazilian Portuguese version of the ASK has good validity and reliability and may be used by professionals and researchers to assess the functioning of children and adolescents with disabilities.
Overlooked complication of Cushing's syndrome: Reactivation of hepatitis B
Authors: Barlas Tugba , Yalcin Mehmet Muhittin , Ozger Hasan Selcuk , Altinova Alev Eroglu , Akturk Mujde , Toruner Fusun Balos , Karakoc Ayhan , Yetkin Ilhan 
Published: November 2022

AbstractObjectiveIndividuals infected with hepatitis B virus (HBV) are at increased risk of reactivation when they receive immunosuppressive therapies. Although exogenous corticosteroid use as immunosuppressive therapy is elaborated in current guidelines on HBV reactivation, Cushing's syndrome (CS) with endogenous hypercortisolemia is not addressed. We aimed to investigate the prevalence of HBV infection and discuss the necessity of antiviral prophylaxis in patients with CS as in other immunosuppressed patients.Design and PatientsWe included 72 patients with CS (Adrenocorticotropic hormone (ACTH) dependent or independent) who were screened for HBV between 2016 and 2021. Patients were categorized into three groups: overt, mild autonomous cortisol secretion (MACS), and remission according to the cortisol burden. Changes in patients' HBV serology and clinical findings over time were analyzed retrospectively.ResultsTwenty‐six patients had overt hypercortisolism, 18 had mild autonomous cortisol secretion and 28 patients were in remission. Nineteen (26.3%) patients were anti‐HBc IgG positive, 4 of them were chronic HBV and 15 were isolated anti‐HBc IgG positive. HBsAg was positive in four (5.5%) of the patients, who were all compatible with inactive chronic HBV. While two patients developed HBV reactivation, HBV flare was observed in one patient.ConclusionSince it is not always possible to achieve rapid remission in CS and these patients have long‐term hypercortisolemia, we suggest that consensus should be reached on HBV serological assessment, standardization of follow‐up, and planning of HBV prophylaxis in required instances in patients with CS especially in regions with a high prevalence of HBV infection.
Interface change in early mycosis fungoides: A potential mimicker of benign dermatoses
Authors: Tsang Matthew , McNiff Jennifer M. 
Published: November 2022

AbstractBackgroundHistopathologic features of interface dermatitis can occasionally be seen in mycosis fungoides (MF), particularly in early patch‐stage disease.Materials and MethodsWe identified six patients with MF whose early biopsy specimens showed such prominent interface dermatitis that a benign diagnosis was favored. All subsequent specimens were reviewed for these patients, and the histopathologic evolution of disease was documented. Immunohistochemistry (IHC) for CD2, CD3, CD4, CD5, CD7, CD8, CD30, and CD123 was performed retrospectively. Educational archives were reviewed to assess the incidence of interface dermatitis in biopsies otherwise diagnostic of MF.ResultsA spectrum of vacuolar and lichenoid patterns of interface change was observed in this series of six patients eventually diagnosed as having MF, and was seen as a recurring pattern in multiple specimens over time. In retrospect, findings described in early MF such as lining up of lymphocytes along the dermal–epidermal junction within the basal layer, papillary dermal fibrosis, and intraepidermal lymphocyte atypia could be appreciated to varying degrees in the confounding specimens. CD123 was negative in all cases, putatively excluding a connective tissue disease (CTD). None of the early biopsies showed loss of pan‐T antigens CD2, CD5, and CD7. Forty‐six of 164 cases (28%) of MF in an archival study set showed varying degrees of interface dermatitis in the setting of otherwise diagnostic changes of MF.ConclusionsEarly MF can show prominent interface change and mimic inflammatory dermatoses. Histopathologic clues suggestive of MF should be carefully assessed, and IHC for CD123 may be helpful in distinguishing MF from CTD. Repeat biopsies over time may be necessary to arrive at a definitive diagnosis, in conjunction with ancillary studies and strong clinicopathologic correlation.
Cannabis use, risk behaviours and harms in Brazil: A comprehensive review of available data indicators
Authors: Daldegan‐Bueno Dimitri , Lindner Sheila R. , Kovaleski Douglas , Fischer Benedikt 
Published: November 2022

AbstractIssuesCannabis use and related health/social outcome indicator data for Brazil—where non‐medical cannabis is generally illegal—are limited.ApproachTowards a comprehensive overview of relevant indicators, we searched primary databases by combining MeSH‐index terms related to cannabis, geographic location and subtopic terms (e.g., use, health, mortality) focusing on cannabis use and key outcome indicators in Brazil since 2010. In addition, relevant ‘grey literature’ (e.g., survey reports) was identified. Key indicator data were mainly narratively summarised.Key FindingsOverall, cannabis use has increased somewhat since pre‐2010, with (past‐year) use rates measured at 2–3% for general population adults, yet 5% or higher among youth and/or (e.g., post‐secondary) student populations. For key risk behaviours, the presence of tetrahydrocannabinol‐positivity among motor‐vehicle drivers has been measured at <2%. While the prevalence of cannabis use disorder appears to have decreased, the relative proportion of treatment provided for cannabis‐related problems increased. National‐ and local‐based studies indicated an association of cannabis use with mental health harms, including depression and suicidality. Although some non‐representative and/or local studies contain information, other monitoring data, including cannabis‐related risks and harms (e.g., cannabis‐related driving, mortality, hospitalisations), are limited in availability.Implications and ConclusionThe prevalence of cannabis use in Brazil is comparably low (e.g., relative to elsewhere in the Americas). Data on numerous key cannabis‐related indicators is absent, or limited in scope for Brazil. Considering ongoing evolutions in cannabis control and its status as the most common illicit drug, more comprehensive surveillance of cannabis use and related outcomes is advised.
Subcellular compartmentalization of STIM1 for the distinction of Darier disease from Hailey‐Hailey disease
Authors: Stanisz Hedwig , Mitteldorf Christina , Janning Helena , Bennemann Anette , Schön Michael P. , Frank Jorge 
Published: November 2022

SummaryBackground and objectivesDarier disease (DD) and Hailey‐Hailey disease (HHD) are rare disorders caused by mutations in the ATPase, Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2 (ATP2A2) and ATPase Ca2+ Transporting Type 2C, Member 1 (ATP2C1) gene, respectively, which lead to a disturbance of calcium metabolism in keratinocytes. Clinically, this is reflected by an impairment of keratinization. Histologically, acantholysis with variable degrees of dyskeratosis and parakeratosis is observed. Both diseases can usually be differentiated clinically, histopathologically and genetically. However, their routine distinction might be challenging since some patients do not harbor ATP2A2 or ATP2C1 mutations. To solve this diagnostic challenge, we studied the differential expression of two proteins of store‐operated calcium entry (SOCE), stromal interaction molecule 1 (STIM1) and calcium release‐activated calcium modulator 1 (ORAI1), by immunohistochemistry.Patients and methodsFive individuals with ambiguous diagnostic findings and eight controls with an unambiguous diagnosis were studied clinically, histologically, genetically, and by immunohistochemistry for STIM1 and ORAI1.ResultsDD patients consistently showed a cytoplasmic STIM1 expression while patients with HHD revealed a membrane‐associated staining pattern. In contrast, ORAI1 did not show a differential expression pattern.ConclusionsOur data suggest subcellular compartmentalization of STIM1 as novel biomarker for the distinction of the two disorders.
Education, Instrumentality, and the Lessons of Useless Art
Authors: Ruitenberg Claudia 
Published: November 2022

AbstractIn this article, Claudia Ruitenberg argues that the debate for or against instrumentalism in education is less fruitful than (a) a debate about the ends worth striving for, regardless of whether education is the best means to that end; and (b) a debate about the educational practices that are currently valued in and of themselves, regardless of whether these will turn out to serve other ends in the future. Using examples from visual art and examining arguments for and against “art for art's sake” and “education for education's sake,” Ruitenberg argues that education designed for instrumental purposes is already infected by a certain uselessness, while education that supposedly serves no purpose outside of itself “suffers” from a certain usefulness.
Heidegger's Hammer: Ontology, Aesthetics, and the Instrumental in Education
Authors: Szkudlarek Tomasz 
Published: November 2022

AbstractIn the context of the ongoing debate on the ontology of education, where instrumentally defined functions and aims are seen as external to what education is and the focus is on defining “the educational,” Tomasz Szkudlarek explores a reverse route in an attempt to see, first, what is “the instrumental” before asking how it operates in education. He assumes that instrumentality may be an ontological phenomenon if we adopt a relational ontology where “things” are always and essentially related to other things, also functionally and instrumentally. To examine this path, Szkudlarek starts with Martin Heidegger's understanding of tools, also in its radicalized version proposed by Graham Harman, and contrasts their conceptions with the phenomenology of tools focusing on their aesthetic value. Through this juxtaposition, educational instrumentality appears as more complex and problematic than much of the current critique assumes, and tools appear as active and seductive elements of the educational.
Reframing Education Beyond the Bounds of Strong instrumentalism: Educational Practices, Sensory Experience, and Relational Aesthetics
Authors: Todd Sharon 
Published: November 2022

AbstractIn this contribution, Sharon Todd moves beyond the bounds of what she calls “strong” instrumentalism (one that posits education in a mechanistic fashion and operates politically through a marrying of national educational policies with economic interests) and explores the intrinsic purpose of educational practice specifically through an aesthetic lens. Todd considers how two art projects by the feminist art collective Sisters Hope offer a way of theorizing instrumentalism in a “weak” sense — that is, an instrumentalism that sees pedagogical practices not in terms of social function, but as that which gives form to specifically educational (not social or economic) ideas. She does this by drawing parallels between education and art as fields of practice, informed by notions of experience, relation, and formation/transformation. Drawing on John Dewey's aesthetics and Nicolas Bourriaud's relational aesthetics, Todd argues how these notions are central to an understanding of “weak” instrumentalism in education.
The Destruction of a Great Idea: Public Education and the Politics of Instrumentalism
Authors: Säfström Carl Anders 
Published: November 2022

AbstractThis article explores the erosion of public education as a project of democratization. It locates this erosion in the neoliberal world order that has redefined our understanding of schooling the democratic citizen in terms of developing market assets. In it, Carl Anders Säfström investigates specifically how this shift is apparent in the ways in which schooling operates and demonstrates how education itself stands in stark contrast to this view of schooling's function. The need to revitalize education and teaching as means to further equality in society derives from the inequality that neoliberal schooling produces and that is undermining the democratic character of reputedly democratic orders. Teaching liveable life, Säfström concludes, means to verify equality in situations otherwise defined by inequality and, by this means, to expand who can be seen as belonging to democratic public life. His critique of political instrumentalism shows how late capitalism's neoliberal market ideology is systematically linked with schooling and results in the institutionalization of this ideology.
Artificial light affects the foraging behavior in greater white‐toothed shrews (CROCIDURA RUSSULA)
Authors: Aparício Guilherme , Carrilho Maílis , Oliveira Flávio , Mathias Maria da Luz , Tapisso Joaquim T. , von Merten Sophie 
Published: November 2022

AbstractLight pollution is one of the forms by which human‐induced alterations are changing natural environments. Artificial light at night (ALAN) has been increasing over the past decades and it is already known that ALAN can have a major influence on the ecology, behavior, and physiology of different taxa. Nocturnal small mammals are particularly vulnerable, as ALAN can increase their predation risk while foraging. The aim of this study was to investigate foraging strategies under different light conditions in a nocturnal small insectivore, the greater white‐toothed shrew (Crocidura russula). Compared with rodents, shrews have a higher metabolic rate and thus present a good model for a foraging study. In three laboratory experiments with wild‐caught shrews we tested (i) food preference under dark conditions as well as the effect of different light conditions on (ii) foraging strategies and (iii) food choice. The results showed that shrews had a clear food preference under dark conditions. They also preferred to forage under dark over light conditions when presented with the same food in both conditions. However, when presented with the choice of foraging their preferred food under illuminated conditions or a lower food quality in the dark, the food preference of shrews overruled their preference for feeding in the dark. It seems that food preference, rather than risk perception, is the main driver determining the foraging strategy of the greater white‐toothed shrews. This study suggests that ALAN does not necessarily prevent high‐metabolic nocturnal insectivores from achieving their energetic needs, which might help explain their persistence in urban environments.
Fishing for biodiversity by balanced harvesting
Authors: Law Richard , Plank Michael J. 
Published: November 2022

AbstractFisheries are damaging and seemingly incompatible with the conservation of marine ecosystems. Yet fish are an important source of food and support the lives of many people in coastal communities. This paper considers an idea that a moderate intensity of fishing, appropriately scaled across species, could help in maintaining biodiversity, rather than reducing it. The scaling comes from an intuition that rates of fishing mortality of species should be kept in line with production rates of the species, a notion known as balanced harvesting. This places species conservation and exploitation on an equal footing in a single equation, showing quantitatively the relative levels of fishing mortality that species of different abundance can support. Using a dynamic model of a marine ecosystem, we give numerical evidence showing for the first time that fishing, if scaled in this way, can protect rarer species, while allowing some exploitation of species with greater production. This works because fishing mortality rates, when scaled by production, are density‐dependent. Such fishing, operating adaptively to follow species' production rates over time, contains a feedback that would help to protect species from overfishing in the presence of uncertainty about how marine ecosystems work.
A comprehensive review and analysis of Masing/non‐Masing behavior of materials under fatigue
Authors: Yadav Sanjeev Singh , Roy Samir Chandra , Goyal Sunil 
Published: November 2022

AbstractOver the last 50 years, many researchers have contributed significantly towards understanding the Masing/non‐Masing behavior of materials. However, there has been no review article or scientific report published to date that highlights the progress made in this domain. This article presents a state‐of‐the‐art comprehensive review and analysis of the Masing/non‐Masing behavior of materials under low cycle fatigue loading. Understanding of Masing/non‐Masing behavior is important for the development of fatigue‐resistant materials, prediction of fatigue life, and constitutive modeling and simulation. The influence of various factors such as stacking fault energy, temperature, strain amplitude, and loading conditions on Masing/non‐Masing behavior has been summarized in this article. The literature pertaining to the internal microstructural changes observed in different materials by various researchers has been collected and compiled. The different methods of analyzing Masing/non‐Masing behavior reported in the open literature are assessed and presented. The importance/significance of Masing/non‐Masing behavior in constitutive modeling and fatigue life prediction has also been highlighted. Finally, conclusions based on the review and the potential problems required to be resolved in the future are also pointed out.