bluuebunny/crossref_metadata_2025_split huggingface dataset:
What stabilizes pre-folded structures in the intrinsically disordered α-helical binding motifs?
Authors: Hadži San , Purič Samo , Zavrtanik Uroš , Vranken Wim 
Published: January 2022

AbstractMany examples are known of regions of intrinsically disordered proteins (IDPs) that fold into α-helices upon binding their globular protein targets. In their unbound state these regions possess a small amount of residual helicity, referred to as pre-folded structure, which has been studied on case by case basis. In order to investigate what determines these pre-folded structures we compiled a database of peptides that fold-upon-binding, and experimentally characterized their helicity in the unbound and target-bound state. These regions are more hydrophobic and lack proline residues compared to IDPs in general. On average they possess about 17% helicity in the pre-folded state and gain 40% of helicity upon target binding. We observe that the locations of pre-folded helical regions strongly overlap with those in the targetbound IDPs. To understand this correlation, we analyzed per-residue energetic contributions stabilizing helical structure and found that target-interacting IDP have higher helix propensity. Notably, leucine is the most common residue involved in IDP-target interactions and, due to its high helix propensity, it strongly stabilizes pre-folded helical structures. For many IDP binding motifs, particularly those enriched in leucine, we observe that they not only mediate target-interactions but also confer stability to the pre-folded structure. Collectively, this shows that the formation of pre-folded helical elements is coupled to the IDP-target interactions, explaining why such elements are a common feature of α-helical binding motifs. Moreover, it probably explains the preference for leucine among IDP-target hotspots, even though this residue is underrepresented among hotspots in the interfaces between globular proteins.
Chief marketing officers' future focus and firms' sustainability marketing commitment
Authors: Thu Nguyen NQ , Tho Nguyen Dinh 
Published: January 2022

PurposeThis study examines a moderated moderation model in which the hardiness of chief marketing officers (CMOs) moderates the relationship between CMOs' future focus and firms' sustainability marketing commitment (SMC), and this moderating effect is moderated by CMOs' proactive personality.Design/methodology/approachA sample of 298 CMOs of firms in Vietnam was surveyed to collect data. Confirmatory factor analysis was employed to validate the measures of the constructs used in the model and structural equation modeling (SEM) was used to test the model and hypotheses.FindingsThe SEM results reveal that CMOs' future focus had a positive relationship with firms' SMC. Furthermore, both CMOs' hardiness and its interaction with CMOs' future focus had positive effects on firms' SMC. Finally, the three-way interaction between CMOs' future focus, hardiness and proactive personality had a positive effect on firms' SMC.Practical implicationsThe study findings assist firms in emerging markets in understanding the roles of some key personality-based resources of CMOs in fostering firms' SMC.Originality/valueThis study is among the first to investigate the roles of CMOs' personality-based resources (i.e. future focus, hardiness and proactive personality) in firms' SMC, offering insight into the sustainability marketing literature.
Crisis communication, social media and natural disasters – the use of Twitter by local governments during the 2016 Italian earthquake
Authors: Splendiani Simone , Capriello Antonella 
Published: January 2022

PurposeThe objective of this exploratory research is to investigate the role of Twitter in crisis communication by analysing all the earthquake-related messages from local public authorities in four Italian regions (Abruzzo, Lazio, Marche and Umbria) during the seismic sequence that began on 24th August 2016 and finished at the end of January 2017.Design/methodology/approachThe study is based on a manual data collection of earthquake-related tweets. Founded on a theoretical framework, the data analysis has been developed both through textual analysis and in-depth interpretation by two researchers to catalogue the messages according to identified categories.FindingsIt emerges that the affected Italian regions used Twitter only for information coverage without offering a complete and detailed picture of the disaster. Most of the tweets concerned daily statements by politicians or regional administrators engaged in crisis management, while an accurate selection of the topics and messages to be launched does not emerge, with significant implications on the effectiveness of the tweeting activity itself.Originality/valueThis paper aims to contribute to the literature on crisis communication and social media during a natural disaster, highlighting the criticalities shown by the Italian case studies. The originality of this study relates to the comparative examination of Twitter activities for four regional government bodies involved in the 2016 Italian earthquake.
Quadri-directional optical bending sensor using side-emitting POF integrated with wearable device technology in smart glove
Authors: Lin Miao-Tzu 
Published: January 2022

PurposeIt is important to monitor wrist four direction movements (flexion, extension, adduction and abduction) for hand healthcare, wrist rehabilitation and upper limb exercise, and so on. The purpose of this study is to develop a quadri-directional optical bending sensor that integrated wearable device technology in a smart glove to detect wrist four direction movements.Design/methodology/approachThe quadri-directional optical bending sensor was designed with a microcontroller board, a Bluetooth wireless module, a side-emitting polymeric optical fibre (POF), an infrared light emitting diode and four phototransistors. A linear equation was deduced to calculate bending angle from detecting sensor value of Arduino microcontroller. The bending angle values could be seen by the smartphone screen, so the system has a good human–machine interface function.FindingsThe light emission by macro-bending of the side-emitting POFs that the transmittance of the outer side is greater than the inner. The bending POFs lateral emission phenomenon integrated with phototransistors on the edge is suitable for the development of bending sensors.Originality/valueThis study is to develop a novel quadri-directional optical bending sensor to replace two bi-direction sensors or four uni-direction sensors for wrist four direction movements monitoring.
Management of inventory for firms’ efficiency – a study on steel manufacturing industry
Authors: Panigrahi Rashmi Ranjan , Mishra Padma Charan , Samantaray Alaka , Jena Duryodhan 
Published: January 2022

PurposeThe purchase is becoming a more difficult cum tactical decision that affects the cost factor, quality factor, time factor and responsive factor of the buy and maintains them. The purpose of this study is to investigate the effect of inventory management (IM) practices on operational efficiencies (OEs) in Indian steel manufacturing firms.Design/methodology/approachThe study is based on a quantitative research design that has collected information from 321 key officials of Indian steel manufacturing firms. The analyses are carried out with the use of statistical techniques such as confirmatory factor analysis and structural equation modeling (SEM).FindingsThe paper finds that inventory management (IE) has a considerable impact on the OE of steel manufacturing firms in India. The manufacturing industry must highlight the significance of inventory management practice (IMP) for enhancing firm efficiencies in a volatile environment with the help of management teams. Understanding the impact of IE practices on firms’ OE would be helpful for company shareholders and investors.Practical implicationsThe paper suggests the manufacturing industry to emphasize the role of inventory management practices to have better productivity of the firm. This research focuses on the relationship between IMP and OE.Social implicationsEffective and efficient use of inventory will be helpful in reducing the overall cost of production and reduced costs to customers.Originality/valueCompanies require resources to attain a long-term competitive edge. Also, as a consequence, the research is compatible with resource-based view (RBV) theory.
The consequences of repeatedly losing on legitimacy beliefs
Authors: KERN ANNA , KÖLLN ANN‐KRISTIN 
Published: January 2022

AbstractModern democracies are dependent on regular elections and citizens’ legitimacy beliefs. Studies have shown that repeated electoral defeats are associated with lower levels of satisfaction with democracy and political trust. However, previous studies have only considered one type of legitimacy belief at a time, never in comparison. What is more, all previous work is based on observational studies and has not been able to identify any causal effects of losing repeatedly. Building on previous work and classic theories of political legitimacy beliefs, we argue that repeatedly losing in elections represents a form of long‐term exclusion from democratic power that has additional negative effects on people's legitimacy beliefs because they lose faith in the system and start questioning its evenhandedness. We support our predictions using six‐wave panel data and test our hypothesis a total of 16 times within the same context. The findings show that repeated losers are never less satisfied with democracy but that an additional electoral loss leads to lower levels of political trust. The findings have important implications for the meaning of different indicators of legitimacy beliefs but also for electoral research and the underpinnings of stable democracies.
Effects of roasting on bioavailability and bioactivities of Vigna angularis and potential of coffee‐like beverage
Authors: Bolek Sibel 
Published: January 2022

AbstractContaining similar aroma and flavor profile of coffee after roasting, Vigna angularis have potential to be a caffeine‐free coffee‐like beverage. Microwave roasting process was conducted in a microwave oven at 600 W for 7, 14, and 21 min at 2‐min intervals, and fluidized bed roasting process was conducted in a fluidized bed roaster at 200°C for 9, 18, and 27 min. In order to compare the roasted beans, color, fat, ash, crude protein, crude fiber, antioxidant activity, and total phenolic content measurements were performed. In addition, effects of roasting methods on protein bioavailability and antinutritional factors were investigated. Sensory test was conducted to compare the coffee and coffee‐like beverages. Fluidized‐bed roasted beans had higher scores than microwave roasted beans in terms of sensory acceptability (p ≤ 0.05). Roasting process increased the total phenolic contents up to 25.32 (mg GAE/g) and the protein bioavailability up to 89.82 ± 0.11%. The results of this study revealed that roasting can be used as a tool to increase nutritive value, bioavailability, antioxidant activity, and potential of coffee‐like beverage of V. angularis.Practical ApplicationSince Vigna angularis beans contain similar aroma and flavor profile of the coffee after roasting, they have a potential to be a caffeine‐free coffee alternative. Although coffee is very popular in demand, most of the coffee drinkers think that caffeine is very harmful. Having similar sensory scores as coffee beverages in certain roasting degrees, V. angularis beverages could be a delicious caffeine‐free alternative.
Perioperative hypothermia in open and laparoscopic colorectal surgery
Authors: Cumin David , Fogarin Jessica , Mitchell Simon J. , Windsor John A. 
Published: January 2022

AbstractBackgroundThe consequences of even mild inadvertent perioperative hypothermia (IPH) are significant. There is a perception laparoscopic abdominal surgery is less prone to cause hypothermia than open surgery. However, during laparoscopic surgery, the peritoneal cavity is insufflated with carbon dioxide, which has a greater evaporative capacity than ambient air. This study compared the intra‐operative temperature profile of patients undergoing open and laparoscopic colorectal surgery to define the incidence and severity of hypothermia.MethodsAll adult patients undergoing colorectal surgery between May 2005 and August 2013 were identified from an electronic database. Cases were categorized into laparoscopic and open cases. Hypothermic episodes were defined as a temperature less than 36°C lasting for more than two consecutive minutes. The incidence of hypothermic episodes, the total time under 36°C and the area under the curve (degree–minutes) were calculated.ResultsA total of 1547 cases were analysed. The overall incidence of hypothermia was 67.0%. The incidence of cases with a hypothermic episode was greater in the laparoscopic group compared to the open group (71.23% versus 63.16%; chi‐squared P‐value 0.001). However, when other factors were considered, there was no significant difference in the relative risk of a hypothermic episode between types of surgery. There were significant differences in the severity of hypothermia.ConclusionDespite current measures to reduce the incidence, IPH remains a significant problem in colorectal surgery irrespective of the surgical approach. Further research is required to better characterize techniques that can reduce its incidence.
Laparoscopic posterior pelvic exenteration for clear cell adenocarcinoma arising in an episiotomy scar
Authors: Kasahara Keiko , Itatani Yoshiro , Kawada Kenji , Takahashi Yuwa , Yamamoto Takamasa , Hoshino Nobuaki , Okada Tomoaki , Oshima Nobu , Hida Koya , Nishigori Tatsuto , Hisamori Shigeo , Tsunoda Shigeru , Obama Kazutaka 
Published: January 2022

AbstractMalignant degeneration of endometriosis is a very rare event, especially when it develops in an episiotomy scar. A 53‐year‐old woman with an enlarged perineal mass presented to the hospital. She had undergone vaginal delivery with episiotomy twice. Imaging analyses showed a mass involving the levator ani muscle apart from the rectum, with lymph node metastases to the right inguinal and internal iliac regions. A biopsy specimen of the right inguinal lymph node revealed poorly differentiated adenocarcinoma. She underwent neoadjuvant chemotherapy according to the treatment strategy of anal fistula cancer. Laparoscopic posterior pelvic exenteration and pelvic lymph node dissection with anterior inguinal node dissection was performed, along with perineal reconstruction. Pathological examination revealed clear cell adenocarcinoma with lymph node metastases, derived from extrapelvic endometriosis in the episiotomy scar. She was treated with adjuvant chemotherapy according to the treatment strategy of vulvar cancer, and showed no evidence of recurrence after 15 months of surgery.
Late Mesozoic sandstone volumes recorded in Gulf of Mexico subsurface depocentres: Deciphering long‐term sediment supply trends and contributions by paleo river systems
Authors: Snedden John W. , Hull Harry L. , Whiteaker Timothy L. , Virdell Jon W. , Ross Catherine H. 
Published: January 2022

AbstractQuantitative assessment of terrigenous sediment flux to the deep basin has mainly been limited to the Cenozoic Era, given challenges with reconstruction of more ancient source to sink systems. Subsurface mapping in the northern Gulf of Mexico basin, where there is a robust database of wells and seismic data, allows estimation of sand‐size grain volumes within 12 chronostratigraphically defined Late Mesozoic supersequences. Five subsurface depocentres with thicknesses of >400 m are identified, revealing a history of sediment routing via major fluvial axes (paleo rivers) southward from a mid‐continent drainage divide. The interpreted paleo‐rivers are further confirmed by compilation and synthesis of published and novel detrital zircon provenance data showing combinations of age peak subsets that vary considerably between depocentres. This study quantifies sediment volumes within each depocentre by inverting porosity over defined gross rock volumes derived from subsurface well logs and 2D seismic mapping. Two temporal trends of progressively increasing grain volume can be related to climatic effects on fluvial discharge and sediment delivery to the depocentres: (1) Late Jurassic to Early Cretaceous (Oxfordian to early Aptian) and (2) Late Cretaceous (Late Aptian to Coniacian). The first temporal trend probably reflects the local climate becoming less arid with northward drift of the North American Plate into higher latitudes. The second trend mirrors increasing Cretaceous paleotemperatures and rising global sea levels. This second trend is also marked by increased shelf margin bypass of sand indicated by deep basin drilling. Partitioning of Late Mesozoic grain volume by fluvial axes shows that the Paleo‐Apalachicola and Paleo‐Mississippi rivers, sourced from Appalachian basement terranes, generated the largest and longest terrigenous sediment flux into the Gulf of Mexico basin in the Late Mesozoic. Overall, Late Mesozoic siliciclastic grain volumes are estimated to be an order of magnitude less than those previously documented for the Cenozoic Era.
Allergic contact dermatitis caused by 2‐hydroxyethyl methacrylate and ethyl cyanoacrylate contained in cosmetic glues among hairdressers and beauticians who perform nail treatments and eyelash extension as well as hair extension applications: A systematic review
Authors: Symanzik Cara , Weinert Patricia , Babić Željka , Hallmann Sarah , Havmose Martin S. , Johansen Jeanne D. , Kezic Sanja , Macan Marija , Macan Jelena , Strahwald Julia , Turk Rajka , van der Molen Henk F. , John Swen M. , Uter Wolfgang 
Published: January 2022

AbstractCurrent cosmetic regulations primarily focus on protecting consumers, not the professional user who is subjected to a partly different, and certainly more intense exposure to hazardous substances. Against this background, this systematic review aims to compile and appraise evidence regarding skin toxicity of 2‐hydroxyethyl methacrylate (HEMA; CAS no. 212‐782‐2) and ethyl cyanoacrylate (ECA; CAS no. 7085‐85‐0) contained in cosmetic glues used among hairdressers and beauticians who perform nail treatments and eyelash extension as well as hair extension applications. This systematic review followed the Preferred Reporting Items for Systematic review and Meta‐Analysis (PRISMA) 2020 recommendations for reporting systematic reviews and meta‐analysis. In total, six publications from six countries were eligible for this systematic review. A meta‐analysis revealed that hairdressers and beauticians have a ninefold increased risk of developing contact allergy to HEMA compared with controls who are not hairdressers and beauticians. Results for ECA are lacking. The results of this systematic review clearly show that—regarding contact allergy to acrylates—it is not appropriate to apply risk assessment for consumers to hairdressers and beauticians who occupationally handle cosmetic glues. The regulations in existence do not adequately address occupational risks for hairdressers and beauticians connected with the use of acrylate‐containing cosmetic substances and need reconsideration.
Security alert: Generalized deep multi‐view representation learning for crime forecasting
Authors: Zheng Ziwan , Xia Yu , Chen Xiaocong , Yao Junwei 
Published: January 2022

AbstractCrime is a focal problem in modern society, affecting social stability, public safety, economic development, and life quality of residents. Promptly predicting crime occurrence places in a relatively high accuracy is a very important and meaningful research direction. Via the rapid development of social media (e.g., Twitter), the online information can act as a strong supplement for the offline information (crime records). Additionally, the geographic information and taxi flow between communities can model the spatial relationship between communities, which has already been confirmed effective in previous work. In order to efficiently solve crime prediction problem, we propose a generalized deep multi‐view representation learning framework for crime forecasting. Our extensive experiments on a 4‐month city‐wide dataset that consists of 77 communities and 22 crime types show our model improve the prediction accuracy on most crime types.
Dysfunction of metabolic activity of bone marrow mesenchymal stem cells in aged mice
Authors: Li Xiaoyu , Wang Xue , Zhang Chunmei , Wang Jinsong , Wang Songlin , Hu Lei 
Published: January 2022

AbstractObjectivesEvidences have suggested that the metabolic function is the key regulator to the fate of MSCs, but its function in senescence of MSC and the underlying mechanism is unclear. Therefore, the purpose of this study was to investigate the metabolic activity of MSCs and its possible mechanism during aging.Materials and MethodsWe used the Seahorse XF24 Analyzer to understand OCR and ECAR in BMSCs and used RT‐PCR to analyze the gene expression of mitochondrial biogenesis and key enzymes in glycolysis. We analyzed BMSC mitochondrial activity by MitoTracker Deep Red and JC‐1 staining, and detected NAD+/NADH ratio and ATP levels in BMSCs. Microarray and proteomic analyses were performed to detect differentially expressed genes and proteins in BMSCs. The impact of aging on BMSCs through mitochondrial electron transport chain (ETC) was evaluated by Rotenone and Coenzyme Q10.ResultsOur results demonstrated that the oxidative phosphorylation and glycolytic activity of BMSCs in aged mice were significantly decreased when compared with young mice. BMSCs in aged mice had lower mitochondrial membrane potential, NAD+/NADH ratio, and ATP production than young mice. FABP4 may play a key role in BMSC senescence caused by fatty acid metabolism disorders.ConclusionsTaken together, our results indicated the dysfunction of the metabolic activity of BMSCs in aged mice, which would play the important role in the impaired biological properties. Therefore, the regulation of metabolic activity may be a potential therapeutic target for enhancing the regenerative functions of BMSCs.
Reducing demand for overexploited wildlife products: Lessons from systematic reviews from outside conservation science
Authors: MacFarlane Douglas , Hurlstone Mark J. , Ecker Ullrich K. H. , Ferraro Paul J. , van der Linden Sander , Wan Anita K. Y. , Veríssimo Diogo , Burgess Gayle , Chen Frederick , Hall Wayne , Hollands Gareth J. , Sutherland William J. 
Published: January 2022

AbstractConservationists have long sought to reduce consumer demand for products from overexploited wildlife species. Health practitioners have also begun calling for reductions in the wildlife trade to reduce pandemic risk. Most wildlife‐focused demand reduction campaigns have lacked rigorous evaluations and thus their impacts remain unknown. There is thus an urgent need to review the evidence from beyond conservation science to inform future demand‐reduction efforts. We searched for systematic reviews of interventions that aimed to reduce consumer demand for products that are harmful (e.g., cigarettes and illicit drugs). In total, 41 systematic reviews were assessed, and their data extracted. Mass‐media campaigns and incentive programs were, on average, ineffective. While advertising bans, social marketing, and location bans were promising, there was insufficient robust evidence to draw firm conclusions. In contrast, the evidence for the effectiveness of norm appeals and risk warnings was stronger, with some caveats.