bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human blood metabolites and lacunar stroke: A Mendelian randomization study
Authors: Guo Meng-Nan , Hao Xiao-Yan , Tian Jie , Wang Yun-Chao , Li Jia-Di , Fan Yu , Shi Jing-Jing , Ma Dong-Rui , Li Shuang-Jie , Zuo Chun-Yan , Liang Yuan-Yuan , Li Meng-Jie , Shen Si , Liu Fen , Yao Da-Bao , Xu Yu-Ming , Shi Chang-He 
Published: November 2022

Background: Lacunar stroke accounts for a quarter of all strokes, but little is known about the underlying pathological mechanisms. Analysis of serum metabolites may allow better understanding of the underlying biological processes. Mendelian randomization (MR) can provide information on the causality of associations. Aims: To identify causal relationships between serum metabolites and lacunar stroke. Methods: We applied a two-sample MR analysis to evaluate relationships between 486 serum metabolites and lacunar stroke. The inverse-variance weighted (IVW) method was used to estimate the causal relationship of the exposure on the outcome, while sensitivity analyses were performed using MR-Egger, weighted median, and MR-PRESSO to eliminate the pleiotropy. We also performed a metabolic pathway analysis to identify potential metabolic pathways. Results: We identified 15 known (8 risk and 7 protective) and 14 unknown serum metabolites associated with lacunar stroke. Among the known risk metabolites, two were lipids (1-linoleoylglycerophosphoethanolamine and dihomo-linolenate (20:3n3 or n6)), five amino acids (kynurenine, isobutyrylcarnitine, aspartate, trans-4-hydroxyproline, and 3-methyl-2-oxovalerate), and one peptide (ADSGEGDFXAEGGGVR). The known protective metabolites included four lipids (4-androsten-3beta,17beta-diol disulfate 1, 1-palmitoleoylglycerophosphocholine, adrenate (22:4n6), and glycodeoxycholate), one amino acid (methionine), and two exogenous metabolites (homostachydrine and 2-methoxyacetaminophen sulfate). Metabolic pathway analysis identified several pathways that might be involved in the disease. Conclusion: We identified eight risk and seven protective human serum metabolites associated with lacunar stroke. Isobutyrylcarnitine was positively associated with an increased risk of lacunar stroke. In addition, 3-methyl-2-oxovalerate and aspartate may be involved in the disease pathogenesis through metabolic pathways.
Effects of tension band plating on coronal plane alignment of lower extremities in children treated for idiopathic limb length discrepancy
Authors: Erdal Ozan A , Gorgun Baris , Razi Ozan , Sarikaya Ilker A , Inan Muharrem 
Published: November 2022

Purpose: One of the most common treatment methods for moderate limb length discrepancy in children is growth modulation using tension band plating. Coronal plane deformities after tension band plating for limb length discrepancy have been documented as an important complication in articles involving heterogeneous groups consisted of both idiopathic cases and patients with pathological physes. The aim of the study was to determine the rate of coronal plane deformities after treatment of a homogeneous group of idiopathic limb length discrepancy cases with tension band plating and to compare screw constructs of medial and lateral plates. Methods: Patient files were retrospectively reviewed for amount of limb length discrepancy, anatomical femorotibial angle, mechanical lateral distal femoral angle, mechanical medial proximal tibial angle, and inter-screw angles of each plate on both sides of the tibiae and femora. Measurements at each follow-up period were compared to each other. Results: A total of 26 patient files (37 bones) were included to the study. The mean age was 10.5 years. The mean limb length discrepancy was 27.5 mm. Implants were removed after mean 34.5 months. The mean follow-up period was 58.5 months. There was no significant difference in inter-screw angle on each side of the bones at the time of implantation and in lower limb alignments during follow-up. Conclusion: Treatment of mild-to-moderate idiopathic limb length discrepancy with tension band plating in children was found to be safe against any coronal plane deformity during follow-up until skeletal maturity. Level of evidence: Level IV.
Planes, trains, and automobiles: Commuting in the 2020s and beyond
Authors: Wiese Christopher W. , Calderwood Charles 
Published: November 2022

In this introduction to the special issue about commuting, we invite readers to consider how this frequently occurring worker activity should be integrated and investigated within the organizational sciences. Commuting is ubiquitous in organizational life. Yet, despite this centrality, it remains one of the most understudied topics in the organizational sciences. This special issue seeks to remedy this oversight by introducing seven articles that review the literature, identify knowledge gaps, theorize through an organization science lens, and provide directions for future research. We introduce these seven articles by discussing how they address three cross-cutting themes (Challenging the Status Quo, Insights into the Commuting Experience, The Future of Commuting). We hope that the work within this special issue informs and inspires organizational scholars to engage in meaningful interdisciplinary research on commuting going forward. Plain Language Summary This special issue aims to encourage readers to consider how commuting research can and should be investigated within the organizational sciences. Commuting is a frequently occurring activity of daily living, but remains one of the most understudied topics in the organizational sciences. This special issue aims to address this issue through seven papers which review the literature, identify knowledge gaps, offer theoretical advancement, and yield future research directions. We introduce these seven articles via the presentation of three cross-cutting themes (Challenging the Status Quo, Insights into the Commuting Experience, The Future of Commuting). Our goal is that this special issue will inform and inspire future organizational science research on commuting.
Progressive multifocal leukoencephalopathy outcomes in patients with multiple sclerosis treated with dimethyl fumarate
Authors: Lyons Jennifer , Hughes Richard , McCarthy Kerry , Everage Nicholas , Kapadia Shivani , Miller Catherine , Singhal Priya , Smirnakis Karen 
Published: November 2022

Background and objectives Dimethyl fumarate (DMF), an oral disease-modifying therapy with an established benefit and well-described safety profile, is among the most commonly used therapies for relapsing forms of multiple sclerosis. As of 31 December 2021, >560,000 patients have been treated with DMF, representing >1,190,000 person-years of exposure. Of these, 6413 patients (14,292 person-years) were from clinical trials. Methods and results Progressive multifocal leukoencephalopathy (PML) has occurred in the setting of lymphopenia (<0.91 × 109/L) in patients treated with DMF. We present detailed clinical characteristics and outcomes of the 12 confirmed PML cases occurring in MS patients on DMF as of 21 July 2021. The PML incidence in DMF-treated patients is 1.07 per 100,000 person-years of DMF exposure. Lymphopenia is the common risk for PML in DMF treatment. Discussion DMF-related PML is rare but has occurred in the setting of lymphopenia, supporting the current recommendations for absolute lymphocyte count monitoring in all patients, regardless of age and time on therapy.
Risk of Mortality for Proximal Femoral Fracture in Patients With and Without COVID-19. A Retrospective Cohort Study
Authors: Holub Ashley , Jornet-Gibert Montsant , Ruppenkamp Jill , Holy Chantal E. , Daccach Juan , Torner Pere , Caba-Doussoux Pedro , Muñoz Vives Josep Maria 
Published: November 2022

Background SARS-CoV-2 (COVID-19) has resulted in a widespread loss of lives, morbidity, and major disruptions to the healthcare system. Hip fractures are an emergent condition which require early intervention to reduce increased risk of mortality and morbidity. Infection of SARS-CoV-2 may contribute to increased mortality due to the role of infection and immune response. This study investigated the impact of COVID-19 infection (defined by clinical symptoms) on mortality following proximal femoral fracture (PFF) repair procedures. Methods This study was a retrospective cohort study. Data from the Premier Healthcare Database® was extracted for patients presenting for PFF during 2019 for control, and February 2020-September 2020 to represent a COVID time-period. Results A total of N = 73 953 subjects were enrolled for the 2019 period, and a total of N = 34 842 subjects were enrolled for the COVID period. For the 2019 period, subjects who had a PFF procedure and who had flu/COVID-like illness had 2.47 (CI:2.11, 2.88) times the odds of mortality compared to those who did not have flu/COVID-like illness. Subjects who had a PFF procedure and who had flu/COVID-like illness during the COVID period had 2.85 times (CI:2.36, 3.42) the odds of mortality compared to those who did not have flu/COVID-like illness. For the COVID period, within subjects who did not have a PFF procedure, those with flu/COVID-like illness had increased odds of mortality compared to those who did not have flu/COVID-like illness (OR:2.26, CI:1.57, 3.21). Conclusions Hip fractures present high risk for mortality and morbidity, where timely intervention is critical to improved outcomes. Presence of infection such as flu/COVID-like illness may influence mortality in patients undergoing hip fracture repair procedures. Consideration of infection status as a comorbidity is important to proper management and achieving optimal outcomes.
The Risk of Adverse Events in Smokers Undergoing Spinal Fusion: A Systematic Review and Meta-Analysis
Authors: Nunna Ravi S. , Ansari Darius , Ostrov Philip B. , Dettori Joseph R. , Godolias Periklis , Ortiz-Torres Michael , Elias Elias , Gruber Max , Oskouian Rod J. , Chapman Jens R. 
Published: November 2022

Study Design Systematic review and meta-analysis. Objectives Determine if tobacco use is associated with increased risk of postoperative adverse events within 90 days in patients undergoing spinal fusion surgery. Methods Databases were queried to identify cohort studies that directly compared smokers with non-smokers and provided the absolute number of adverse events and the population at risk. Data quality was evaluated using the Quality in Prognosis Studies tool. Risk ratios (RR) and 95% confidence intervals were calculated and compared between studies. The grading of recommendation, assessment, development and evaluation (GRADE) criteria were used to assess the strength of the evidence. Results Seventeen studies assessing 37 897 participants met the inclusion criteria. Of these, 10 031 (26.5%) were smokers and 27 866 (73.5%) were nonsmokers. The mean age for the study population was 58 years, and 45% were males. Smoking was not associated with increased risk of one or more major adverse events within 90 days following spine surgery (seven studies, pooled RR 1.13, 95% CI [.75-1.71], I2 = 41%). However, smoking was significantly associated with one or more major adverse events in ≤2 level fusion (three studies, pooled RR 2.46, 95% CI [1.18-5.12], I2 = 0%), but not in fusions of ≥3 levels (four studies, pooled RR .87, 95% CI [.70-1.08], I2 = 0%). Additionally, there was no statistically significant association between smoking and any adverse event, nor increased reoperation risk due to adverse events. Conclusions In this meta-analysis, tobacco use was not associated with a statistically significant increased risk of adverse events within 90 days in patients undergoing spinal fusion surgery. Our results are limited by the variable reporting methodology for both complication rates as well as smoking incidence between the included individual studies.
What Preoperative Factors Are Associated With Achieving a Clinically Meaningful Improvement and Satisfaction After Single-Level Transforaminal Lumbar Interbody Fusion for Degenerative Spondylolisthesis?
Authors: Moorthy Vikaesh , Goh Graham S. , Cheong Soh Reuben Chee 
Published: November 2022

Study design Prospective cohort study. Objectives The purpose of this study was to identify preoperative factors associated with clinically meaningful improvement, patient satisfaction and expectation fulfilment at 2 years follow-up in patients undergoing single-level TLIF for degenerative spondylolisthesis. Methods Patients who underwent a primary, single-level TLIF for degenerative spondylolisthesis between 2006 and 2015 were identified from a prospectively maintained institutional spine registry. Baseline characteristics and PROMs including the Oswestry Disability Index (ODI), 36-Item Short-Form Physical Component Score (SF-36 PCS), Mental Component Score (SF-36 MCS), Visual Analogue Scale (VAS) back pain, and VAS leg pain were collected preoperatively, at 1 month, 3 months, 6 months, and 2 years. Results A total of 997 patients were included. Multivariate analyses showed that increasing age (OR 1.039, P < .001) and better preoperative ODI (OR .984, P = .018) were associated with achieving minimal clinically important difference (MCID) for VAS Back. Increasing age (OR 1.032, P = .007) and better preoperative VAS Back (OR .783, P < .001) were associated with achieving MCID for VAS Leg. Lower BMI (OR .952, P = .024) and better preoperative ODI (OR .976, P < .001) were associated with achieving MCID for SF-36 PCS. Importantly, a better preoperative SF-36 MCS was associated with MCID attainment for ODI (OR 1.038, P < .001), satisfaction (OR 1.034, P < .001) and expectation fulfilment (OR 1.024, P < .001). Conclusion Patients who were older, have less preoperative disability and better preoperative mental health were significantly more likely to attain clinically meaningful improvement in PROMs and postoperative satisfaction after single-level TLIF. Identification of these factors would aid surgeons in patient selection and surgical counselling for single-level TLIF.
Reliability of Inflammatory Markers as a Diagnostic Tool for Non-Diabetic Foot and Ankle Infections: Case Series Study
Authors: Barakat Ahmed , Ahmed Amr , White Helena , Mangwani Jitendra 
Published: November 2022

Category: Other; Ankle; Basic Sciences/Biologics; Hindfoot; Midfoot/Forefoot; Trauma Introduction/Purpose: The distinction between foot and ankle wound healing complications as opposed to infection is crucial for the appropriate and efficacious allocation of antibiotic therapy. Multiple reports have focused on the diagnostic accuracy of different inflammatory markers, however, mainly in the diabetic population. Our aim was to evaluate the diagnostic accuracy of white cell count (WCC) and C-reactive protein (CRP) as diagnostic tools for this distinction in the non-diabetic cohort. Methods: Data were reviewed from a prospectively maintained Infectious Disease Unit database of 216 patients admitted at Leicester University Hospitals - the United Kingdom with musculoskeletal infections over the period between July 2014 and February 2020 (68 months). All patients with a confirmed diagnosis of diabetes were excluded while only those with a confirmed microbiological or clinical diagnosis of foot or ankle infection were included in our study. For the included patients, we retrospectively retrieved the inflammatory markers (WCCs and CRP) at the time of presentation and during the perioperative period for debridement. Values of CRP 0-10 mg/L and WCC 4.0-11.0 x109 /L were considered normal. Results: After the exclusion of patients with confirmed diabetes, 25 patients with confirmed foot or ankle infections were included. All infections were confirmed microbiologically with positive intra-operative culture results. 7 (28%) patients with osteomyelitis (OM) of the foot, 11 (44%) with OM of the ankle, 5 (20%) with ankle septic arthritis, and 2 (8%) patients with post- surgical wound infection were identified. Previous bony surgery was identified in 52% (n=13), either a corrective osteotomy or an open reduction and internal fixation (ORIF) for a foot or ankle fracture with the infection developing on top of the existing metalwork. 84% (n=21) did have raised inflammatory markers while 16% (n=4) failed to mount an inflammatory response even with subsequent debridement and removal of metalwork. CRP sensitivity was 84%, while WCC sensitivity was only 28%. Conclusion: CRP has relatively good sensitivity in the diagnosis of foot and ankle infections in non-diabetic patients, whereas WCC is a poor inflammatory marker in the detection of such cases. In presence of a clinically high level of suspicion of foot or ankle infection, a normal CRP should not rule out the diagnosis of OM.
Use of the Pain Catastrophizing Scale to Predict Other Patient-Reported Outcome Measures Among Plantar Fasciitis and Chronic Ankle Instability Patients
Authors: Baxter Nicholas A. , Hoch Caroline P. , Reid Jared J. , Scott Daniel J. , Gross Christopher E. 
Published: November 2022

Category: Ankle; Hindfoot; Midfoot/Forefoot Introduction/Purpose: The Pain Catastrophizing Scale (PCS) is a measure of how patients emotionally respond to pain. It is composed of three subscales - rumination, magnification, and helplessness - which address intrusive thoughts of pain, expectations of negative outcomes, and inability to cope with pain. The primary purpose of this study is to (1) compare baseline PCS scores with other baseline PROMs in patients with plantar fasciitis (PF) or chronic ankle instability (CAI). Methods: We retrospectively reviewed the records of 201 patients who reported at least one pre-treatment PCS subscore (rumination=200, magnification=199, helplessness=196, total=194) and were diagnosed with PF (n=116) or CAI (n=98) between 2015 and 2020 in a single fellowship-trained foot and ankle surgeon's clinic. Forty-one (20.4%) patients underwent operative treatment by the primary surgeon and 29 (14.4%) were treated operatively prior to being seen by the primary surgeon. Demographics, comorbidities, treatments, other baseline patient-reported outcome measures (PROMs) (e.g., Visual Analogue Scale [VAS], Pain Disability Index [PDI], 12-Item Short Form Survey [SF-12], 8-Item Somatic Symptom Scale-8 [SSS-8]), and postoperative outcomes were recorded. The average follow-up was 183.92 (range, 0-1,820) days, while the average follow-up duration for the patients treated operatively was 190.56 (range, 15-468) days. Results: The PCS total score and its subscores significantly correlated with the total score and/or subscores of each PROM. Higher PCS total score significantly correlated with worse VAS (p<.001), SF-12 mental (p=.007), PDI total (p<.001), and SSS-8 (p<.001). Only the PCS magnification subscore was significantly greater among patients who did (n=41) undergo surgery (p=.043). Those who had previously undergone foot and/or ankle surgery had significantly higher PCS rumination (p=.012), magnification (p=.006), helplessness (p=.008), and total (p=.003) scores. Likewise, those with a history of substance abuse also had significantly higher PCS scores (p=.005; p=.003; p=.006; p=.003). Conclusion: Significant correlations between PCS scores and other baseline PROMs indicate that strong pain catastrophizers with PF or CAI could be at risk for poor treatment outcomes. PCS scores could be used to tailor treatments for such high-risk patients, as there is evidence regarding the positive impact of cognitive behavior therapy on high pain catastrophizers.
A Citation Analysis Study of the 50 Most-Cited Articles on the Achilles Tendon
Authors: Bernasconi Alessio , Sgadari Arianna , Izzo Antonio , Marasco Domenico , Lintz Francois , Netto Cesar de Cesar , Mariconda Massimo , Smeraglia Francesco 
Published: November 2022

Category: Other; Basic Sciences/Biologics Introduction/Purpose: Achilles tendon injuries represent one of the most common reasons of referral to orthopaedic surgeons. The purpose of this study was to determine the 50 most-cited articles on Achilles tendon pathologies in order to outline their characteristics, examine trends in publication and evaluate the correlation between citations and the quality of evidence. Methods: We searched Web of Science papers with the single keyword 'Achill*'. We identified and analyzed the top 50 most- cited articles and abstracted their characteristics. The methodological quality was assessed using the modified Coleman Methodology Score (mCMS). The correlation between the number of citations, the citation rate (citations/y), the impact factor of the journal for the year 2020 (JIF), the year of publication, the Level of Evidence (LoE), the type of study (tendon rupture, acute tendinopathy, chronic tendinopathy), the sample size and the mCMS was assessed through multiple bivariate analyses (Pearson or Spearman correlation coefficient). Results: Mean number of citations (+-SD) was 244 +- 88.8 (range, 657 to 157), with a total number of citations of 12.194 and a mean citation rate of 12.6 +- 5.4 (range, 28 to 3). The mean impact factor for the ten journals in which the 50 manuscripts were published was 5.1. The citation rate correlated with the number of citations (R=0.56, p<0.001), the year of publication (R=0.60, p<0.001) and the LoE (R=-0.37, p=0.022), but not with the citation rate (p=0.15). The year of publication correlated with the LoE as well (R=-0.43, p=0.008). Also, the quality of studies (in terms of mCMS) correlated with the impact factor of journals (R=0.35, p 0.03) and with the LoE (R=-0.48, p=0.003). Only 20 out of 39 primary studies (51%) had a prospective and comparative design, while 19 studies (48%) were classified as of poor quality (< 50 points using the mCMS). Conclusion: Most-cited articles in the field of Achilles tendon injuries have generally been published on high-impact journals. Although the impact factor positively correlates with the quality of studies, their methodology is poor in almost half of cases. The average Level of Evidence provided by studies and their citation rate are both significantly increasing over time. Citation-based indicators do not represent robust measures of quality in studies dealing with Achilles tendon pathologies.
How to Approach Plantar Fasciopathy in Elite Athletes? A Scoping Review of the Literature
Authors: Bernasconi Alessio , Coppola Martina , Sgadari Arianna , Marasco Domenico , Mariconda Massimo 
Published: November 2022

Category: Sports; Hindfoot Introduction/Purpose: Plantar fasciopathy (PF) is a common orthopaedic condition which often affects athletes and limits their performance. Our aim was to conduct a scoping review of the literature in order to summarise the evidence provided so far in the management of PF in Elite Athletes and identify potential gaps in the current knowledge. Methods: This scoping review followed the six-stage methodological framework of Arksey and O'Malley and was registered in the Open Science Framework (10.17605/OSF.IO/48S3K). Pubmed, Scopus and Web of Science were used to identify elegible papers. After charting of data, studies were pooled into three categories: 1) epidemiological/diagnostic studies, 2) outcome research and 3) studies on the rupture of the plantar fascia. The modified Coleman Methodology Score (mMCS) was used to assess the quality of manuscripts included. Results: Out of 742 initial studies, 10 were selected (109 patients) including 8 Level IV and 2 Level V articles. In four studies (91 athletes), potential risk factors (i.e. pre-existent thickening of the fascia, spike shoes, varus hindfoot/knee alignment) were discussed. In three studies (6 athletes), focusing on plantar fasciitis, the non-surgical treatment led to a satisfactory but poorly- documented outcome. In three studies (12 athletes), the rupture of the fascia was treated conservatively with contrasting results, while surgery was performed only in 2 cases. The mean mCMS was 19 (range, 3 to 42), demonstrating overall poor methodology. Conclusion: The limited number of studies and their poor quality do not allow to define the gold standard treatment of PF in Elite Athletes. Until high-quality studies are provided, clinicians have to rely on the available literature regarding the non- professional or non-athletic population to make the best evidence-based decision.