bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Soft‐Shell Mud Crab (Scylla olivacea) Farming Trend in the Southwest Coastal Region of Bangladesh
Authors: Haque Md. Masudul , Sarker Anirban , Saha Shilpi , Islam Akond Mohammad Rafiqul , Islam Shaikh Nazrul , Baki Mohammad Abdul 
Published: February 2025

ABSTRACTSoft‐shell crab aquaculture practices emerged as a profitable livelihood option in the study area due to its lower vulnerability to changing climatic conditions and high demand in the international market. Therefore, this study aims to identify the current growth of soft‐shell mud crab farming to develop strategies to cope with future challenges. Random sampling was applied to collect primary empirical data from different stakeholders of the crab sub‐sector based on structured and semi‐structured questionnaires. In addition, focus group discussions (FGDs) and key informant interviews (KII) were arranged to collect information from a wide range of expert people to cross‐validate the obtained information during the interviews. The study results indicated that the southwest region of Bangladesh has more than 380 farms having 5.55 ± 0.42 million seed crabs in demand in each cycle which is entirely dependent on wild stock. However, the wild crab harvesting amount has declined from 10.35 ± 2.07 to 4.38 ± 0.83 kg/day/person which represented a highly positive relationship with the active percentage of plastic cages that reduced from 99.43 ± 2.12% to 67.04 ± 4.75% during the investigated years. Farm mortality of stocking crabs has also increased by more than 8% in the last 9 years due to a lack of quality seed crabs. The soft‐shell crab farmers preferred small stocking sizes to get quick moulting, ranging from 30.35 ± 2.59 to 43.50 ± 3.59 g. Most of the crab farmers used only tilapia fish as feed items leading to the increase in unit price from BDT 30.30 ± 1.98 to BDT 80.00 ± 2.46. The feeding demand and cost also increased many folds over the years with an increase in farm numbers and feed prices. So, crab hatchery development and formulated feed supply are inevitable for the sustainable growth of this sector.
Application of humanized mice in the safety experiments of antibody drugs
Authors: Sun Zhimin , Gu Mengyun , Yang Zixuan , Shi Lei , Zhao Liyuan , Zheng Minhui , Wang Yan , Zhang Wei , Han Kexin , Tang Naping 
Published: February 2025

AbstractTherapeutic antibodies are valued for their high specificity and selectivity in immunotherapy. However, the potential toxicity they may elicit underscores the necessity of assessing their preclinical efficacy and safety using suitable animal models. In this context, we review the various categories and applications of humanized mice, which have been engrafted with human cells or tissues to mimic the human immune system. These models are extensively utilized in the nonclinical assessment and development of various antibody drugs, acting as a conduit to clinical research. However, several challenges remain, including the limited lifespan of humanized mice, inadequate engraftment of human cells, and the rudimentary nature of the immune environment in these models. The development of humanized immune system models in mice presents both opportunities and challenges, potentially leading to new insights into the evolution and application of antibody therapeutics.
Exploring the Impact of Dynamic Vulcanization on Ductile–Brittle Transition and Morphology Evolution of PLA/EVA Blends
Authors: da Silva Barbosa Ferreira Eduardo , Luna Carlos Bruno Barreto , dos Santos Filho Edson Antonio , Beatrice Cesar Augusto Gonçalves , Pessan Luiz Antonio , Wellen Renate Maria Ramos , Araújo Edcleide Maria 
Published: February 2025

ABSTRACTBlends of poly (lactic acid) (PLA) enhanced with ethylene‐vinyl acetate copolymer (EVA) and dynamically vulcanized have garnered interest from researchers and the polymer industry due to their versatility and combined properties. These include the high elasticity of EVA and the environmentally friendly characteristics of PLA, which is both a biopolymer and biodegradable. This study aims to produce PLA/EVA blends dynamically vulcanized with dicumyl peroxide (DCP) and evaluate their rheological, thermal, morphological, and ductile–brittle transition properties. The materials were prepared by melting them in an internal mixer and injection molding them to produce impact test specimens. Rheological analysis showed that the compounds with DCP exhibit increased complex viscosity (η*), storage modulus (G′), and loss modulus (G″), indicating the formation of crosslinks and the in situ creation of the PLA‐g‐EVA copolymer. Morphological analysis revealed improved homogeneity with the addition of DCP, characterized by an interconnected, nearly co‐continuous structure, as observed primarily through transmission electron microscopy (TEM). Scanning electron microscopy (SEM) showed that as the temperature decreased, voids appeared on the surface of the PLA/EVA/DCP compounds, reducing impact strength. The ductile–brittle transition temperature for the PLA/EVA/DCP compounds was approximately 17.5°C for compositions with 20% and 30% EVA.
King aorta: Narrative anatomy education
Authors: Yilmaz Halil 
Published: February 2025

AbstractThe aim of this study was to investigate the effects of narrative anatomy education and traditional anatomy education on academic achievement. The study included 64 students who were randomly divided into two groups. The two groups were (n = 32) control (Group 1) and (n = 32) experimental (Group 2). The pretest scores of the two groups were 36.40 ± 12.58 and 35.46 ± 9.18, respectively, and the difference between them was not significant. On this basis, the groups were randomly divided into experimental and control groups. The control group received traditional anatomy instruction, while the experimental group received narrative anatomy instruction in addition to traditional instruction. The posttest scores of the control group were 43.12 ± 10.37, while those of the experimental group were 57.03 ± 14.01, and there was a statistically significant difference (p < 0.001). It is predicted that providing narrative anatomy education in addition to traditional anatomy education will have a positive effect on academic success. The qualitative findings of the study revealed several key findings. Participants in the experimental group reported that narrative education facilitated a deeper understanding and retention of anatomical concepts. They highlighted the use of metaphors and storytelling as helpful in making complex material more relatable and memorable. In addition, students expressed that the narrative approach increased their engagement and motivation, contributing to a more enjoyable learning experience. These qualitative findings highlight the potential of narrative education to complement traditional teaching methods and provide a more holistic and interactive learning experience.
The Impact of Blockchain Technology on Firms' Environmental Innovation: A Technological Push Perspective
Authors: Liao Zhongju , Zhang Mengnan , Shi Yangyan 
Published: February 2025

ABSTRACTEnvironmental innovation helps to achieve sustainable utilization of resources and represents an important measure for promoting the coordinated development of human and environment. Adopting the perspective of technological push—based on information asymmetry theory, cognitive orientation theory, and the resource‐based view—this study constructs a research model capturing the impact of blockchain technology on firms' environmental innovation. This study uses multiple regression analysis to examine the impact of blockchain technology on firms' environmental innovation. It also observes the mediating effect of proactive orientation and the moderating effect of venture capital. The results show that blockchain technology positively impacts firms' environmental innovation, with proactive orientation playing a mediating role between blockchain technology and environmental innovation and venture capital enhancing the positive effect. By analyzing the mechanism between blockchain technology and environmental innovation, this study provides a new theoretical basis for better applying blockchain technology to environmental innovation at the firm level.
Impact of Continuation Versus Interruption of Oral Anticoagulation During TAVI on Health‐Related Quality of Life
Authors: van Ginkel Dirk Jan , Bor Willem L. , Aarts Hugo M. , Dubois Christophe , Backer Ole De , Rooijakkers Maxim J. P. , Rosseel Liesbeth , Veenstra Leo , Delewi Ronak , ten Berg Jurriën M. 
Published: February 2025

ABSTRACTBackgroundOne‐third of patients undergoing TAVR have a concomitant indication for oral anticoagulation. The impact of continuation as compared to interruption of oral anticoagulation during TAVR on health‐related quality of life is unknown.AimsTo investigate the impact of continuation as compared to interruption of oral anticoagulation on health‐related quality of life.MethodsThe POPular PAUSE TAVI (Periprocedural Continuation vs. Interruption of Oral Anticoagulant Drugs during Transcatheter Aortic Valve Implantation) trial was an international, open‐label, randomized, clinical trial performed at 22 European sites. Health‐related quality of life was assessed using the Kansas City Cardiomyopathy Questionnaire (KCCQ) and Short Form‐12 (SF‐12) before, and at 1 and 3 months after TAVR.ResultsA total of 8 patients were included: 431 were assigned to continuation and 427 to interruption of oral anticoagulation. Before TAVR, the mean overall KCCQ summary score was 53.6 (±26.0). At 1 month, the mean change in KCCQ summary score as compared to baseline was +11.4 points (95% confidence interval [CI] 8.0–14.8) in the continuation group and +12.2 points (95% CI 8.8–15.6) in the interruption group (difference −0.7 points; 95% CI −4.6 to 3.1). At 3 months, the mean change was +11.0 points (95% CI 7.3–14.6) versus +13.8 points (95% CI 10.2–17.4), respectively (difference −2.8 points; 95% CI −7.1 to 1.5). Mean changes in SF‐12 physical and mental component summary scores showed no differences between both groups at 1 and 3 months after TAVR.ConclusionsIn patients undergoing TAVR with a concomitant indication for oral anticoagulation, continuation as compared to interruption of oral anticoagulation during TAVR did not significantly impact health‐related quality of life up to 3 months after TAVR.
Tophaceous Gout
Authors: Liu Yunxin , Jiao Yang 
Published: February 2025

ABSTRACTChronic untreated hyperuricemia can lead to polyarticular tophaceous gout from recurrent arthritis, which could cause bone erosion and joint damage. “Overhanging edges” on X‐ray, indicative of bony erosions, are highly specific for gout. Tophaceous gout, though more common in older adults, can occur in younger individuals with prolonged hyperuricemia.
Clinician's primer for soft tissue sarcomas: Nuances of histologic subtypes
Authors: Wisdom Amy J. , Raut Chandrajit P. , Haddox Candace L. , Hornick Jason L. , Jagannathan Jyothi P. , Painter Corrie A. , Baldini Elizabeth H. 
Published: February 2025

AbstractSoft tissue sarcomas are a rare group of mesenchymal malignancies, with greater than 100 histologic subtypes. Advancements in understanding these subtypes has enabled histology‐tailored management. This primer describes the workup and management of generalized soft tissue sarcomas of the extremity, trunk, and retroperitoneum while also highlighting the unique attributes of many subtypes. The subtypes chosen for review include those that are most common as well as those demonstrating unique behaviors or targets for management. The focus is on initial management of localized disease; however, for situations in which novel systemic agents have been discovered, the treatment of metastatic disease is discussed. This report is a reference to be used in addition to other comprehensive reviews, such as guidelines from the National Comprehensive Cancer Network, the European Society for Medical Oncology, and the American Society for Radiation Oncology. It is not a substitute for referral to an expert sarcoma center for critical pathology review and management by an experienced team. Importantly, patients who are treated at expert sarcoma centers have better outcomes than those who are not.
Long‐Term Longitudinal Computational Study of a Marfan Syndrome Patient After Hybrid Repair of Aortic Arch Dissection With Parallel Stent‐Grafts
Authors: Liu Yu , Li Wenfan , Ding Zhihao , Tang Zichun , Luo Yuanming , Hu Jia 
Published: February 2025

ABSTRACTHybrid repair is a valuable alternative treatment for aortic arch disease in Marfan syndrome patients after proximal aorta replacement. This study aimed to investigate the long‐term durability of this technique with the use of parallel stent‐grafts and evaluate strategies to prevent abdominal aortic dilation. One Marfan syndrome patient who underwent hybrid aortic repair with parallel stent‐grafts for arch dissection after the Bentall procedure was admitted. Five patient‐specific three‐dimensional models were reconstructed based on preoperative and follow‐up computed tomography angiography scans. Three hypothetical models addressing the closure of an endoleak or reentry tears were created. Hemodynamic parameters were assessed using computational fluid dynamics. Postoperatively, increased blood flow into the descending aorta and rising abdominal aortic pressure were observed. During the 5‐year follow‐up, no new thoracic aorta‐related adverse events occurred. One early type III endoleak persisted, and three reentry tears were identified in the descending aorta. The abdominal aorta dilated from 31 to 49 mm. Simultaneously addressing both the endoleak and reentry tears was more effective in reducing false lumen pressure and flow velocity in the abdominal aorta and expanding the high‐value relative residence time region. Longitudinal follow‐up imaging demonstrated the long‐term durability of hybrid aortic arch repair with parallel stent‐grafts in a Marfan syndrome patient after ascending aorta replacement. The increased pressure resulting from blood flow redistribution was associated with downstream aortic dilation. Furthermore, computational fluid dynamics simulations can offer predictive analyses for optimizing intervention strategies in the treatment of distal aneurysmal degeneration.
Myeloid‐Mesenchymal Crosstalk in Lung Fibrosis
Authors: Bhattacharyya Aritra , Yadav Preeti , Bhattacharya Mallar 
Published: February 2025

ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a chronic respiratory disease characterized by progressive scarring of the lung parenchyma. While two drugs have been approved by the US Food and Drug Administration (FDA) for IPF, median survival remains limited at 3 years, and the discovery of novel therapeutic targets is urgently needed. Recent studies indicate that immune cells play a critical role in regulating fibrosis. In this Mini Review, we discuss the recent literature focused on cells of the myeloid lineage that serve as key agents of pathologic interorgan communication in fibrosis. These cells are recruited from the bone marrow and have been found to be key drivers of the fibrotic process in the lung.
Yield variation, plasticity, adaptation, and performance ranking of winter wheat varieties across the environmental gradient of the US Pacific Northwest
Authors: Adams Curtis B. , Neely Clark , Graebner Ryan 
Published: February 2025

AbstractThe US Pacific Northwest is a major wheat (Triticum aestivum L.) production region with widely ranging water availability across its dryland and irrigated cropping systems. There have been no evaluations of variation, plasticity, adaptation, and performance of wheat yield due to variety—collectively or individually—that consider the entire environmental gradient of the region, useful for yield gap analysis, informing breeding, and other applications. Our objectives were to provide these evaluations using a large variety trial dataset and an independent dataset. Using linear models covering site‐averaged yields (× variable) from about 1.50 to 12.0 Mg ha−1, upper and lower yield boundaries due to differences in variety performance were characterized by the regression models y = 1.08x + 0.24 and y = 0.906x − 0.13, respectively. The accuracy and usefulness of these functions were validated by the close fit of an independent dataset. Yield plasticity and environmental adaptation of 45 individual wheat varieties were also evaluated using the Finlay–Wilkinson regression approach, which showed wide variation in varietal yield responses to environment and substantial differences in yield stability (i.e., variation around the yield trend). A limitation of this analytical approach has been that the regression coefficients are not directly useful for ranking varieties for yield performance across contrasting environments. A simple transformation procedure of the coefficients into a single metric was effective for rapidly providing such rankings. A limited analysis is presented quantifying the relative contributions of genotype (27%–58% within sites), environment (84% across sites), and their interaction (5% across sites) on regional yields, as well as yield analysis of club wheat. In summary, this work provides useful research tools and a region‐wide perspective on yield traits of Pacific Northwest wheat varieties.
Characterization of a greenbug resistance gene in a wheat breeding line BW 49921
Authors: Li Genqiao , Wolabu Tezera W. , Bai Guihua , Bian Ruolin , Bernardo Amy , Carver Brett F. , Wu Yanqi , Xu Xiangyang 
Published: February 2025

AbstractGreenbug [Schizaphis graminum (Rondani)] is a major wheat (Triticum aestivum L.) pest that causes significant yield losses worldwide. Use of plant resistance is an effective and environmentally friendly strategy to manage greenbug. BW 49921 is a spring wheat breeding line showing resistance to major US greenbug biotypes. Genetic analysis of an F2:3 population from the cross BW 49921 × Breakthrough revealed a single dominant gene conditioning greenbug resistance in BW 49921, and selective genotyping identified a genomic region associated with the greenbug resistance in chromosome arm 7DL. Ten single nucleotide polymorphisms (SNPs) in the target genomic region were converted to kompetitive allele‐specific PCR (KASP) markers to genotype the entire F2 population. Linkage analysis using F2:3 phenotypic data delimited the greenbug resistance gene in BW 49921, designated Gb49921, to a 0.5‐Mb interval between Stars‐KASP419 (598.8 Mb) and Stars‐KASP1061 (599.3 Mb). Gb49921 was 1.0 cM distal to Stars‐KASP419 and 0.6 cM proximal to Stars‐KASP1061. Allelism tests indicated that Gb49921 is not allelic to either Gb3 or Gb8. Gb49921 confers high resistance to greenbug biotypes C, E, H, I, and K and moderate resistance to TX1. The KASP markers developed in this study can be used for marker‐assisted selection of Gb49921 in wheat breeding programs.
Numerical Investigations of a Large Fire Exposure Crib Test—Presenting Different Pyrolysis Modelling Methodologies and Numerical Results
Authors: Nandish Ranjith , Knaust Christian , Zehfuß Jochen 
Published: February 2025

ABSTRACTThe need for numerical‐based approaches to investigate the fire behaviour in buildings with combustible components is growing due to the increasing use of timber by the construction industry to meet the ‘Climate Action Plan 2050’. This requires consideration of the complex kinetic processes that take place during the burning of the wood in the numerical models. This is accomplished by using computational fluid dynamics (CFD) to numerically model the material pyrolysis and combustion processes. This article presents three different approaches for simulating the behaviour of a wood crib fire using the fire dynamics simulator (FDS). These approaches are based on either prescribing the burning rate of the wood directly from the physical experiments or using the kinetic parameters to govern the underlying processes, such as pyrolysis. Wooden crib fire experiments carried out by the RISE Research Institute in Sweden inside the combustion chamber that were used to validate all the methods. The numerical results from the method, that utilised the experimentally determined burning rate, were in good agreement with the experimental results, with a maximum deviation of 6% in the case of HRR. On the other hand, the model that needs kinetic parameters as its input has shown maximum discrepancies of 12% and 33% compared to experimental results. These methods are sensitive to the input parameters and the extent of dependency needs further investigation.
Knockdown of VDAC1 Promotes Ferroptosis in Diffuse Large B‐Cell Lymphoma
Authors: Lin Chuanming , Xin Liuyan , Xie Shuiling 
Published: February 2025

ABSTRACTDiffuse large B‐cell lymphoma (DLBCL) is a prevalent subtype of non‐Hodgkin's lymphoma (NHL). Ferroptosis is a novel form of cell death involved in multiple tumor development. However, the relationship between ferroptosis‐related genes and DLBCL has not been extensively studied. The GSE95290 dataset was downloaded from the Gene Expression Omnibus (GEO) database and merged with genes associated with ferroptosis to screen differentially expressed genes (DEGs). Hub genes were identified by constructing a protein‐protein interaction (PPI) network. The messenger RNA (mRNA) expressions of hub genes were subsequently detected in vitro using reverse transcriptase quantitative polymerase chain reaction (RT‐qPCR). The impact of voltage dependent anion channel 1 (VDAC1) on the proliferation, apoptosis, and ferroptosis of DLBCL was evaluated using Cell Counting Kit‐8, flow cytometry, and relevant ferroptosis assays, respectively. Six highly expressed hub genes were identified, all of which could be used as diagnostic biomarkers for DLBCL. In vitro studies revealed that suppressing VDAC1 expression inhibited DLBCL cell proliferation and promoted apoptosis. Furthermore, knockdown of VDAC1 promoted ferroptosis in DLBCL cells and xenograft tumor models, resulting in elevated levels of malondialdehyde (MDA) and iron and increased protein levels of Acyl‐CoA synthetase long‐chain family 4 (ACSL4) and cyclooxygenase‐2 (COX2). Conversely, glutathione (GSH) and superoxide dismutase (SOD) levels were reduced, accompanied by decreased protein levels of glutathione peroxidase 4 (GPX4) and ferritin heavy chain1 (FTH1). VDAC1 knockdown induces ferroptosis in DLBCL, which provides new insights into the pathogenic mechanisms of DLBCL.