bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vitro Effect of Cholesterol and Different Sugars on Digitonin Production in Multiplied Shoots of Digitalis purpurea L. Plant
Authors: J.Awad Zainab 
Published: March 2022

Production of the steroidal saponin digitonin in multiplied shoots of Digitalis purpurea , (var. Excelsior Mixed) has been achieved in vitro by two experiments. In the experiment 1, shoot tips ( 1cm length ) explants from the sterilized seedlings were excised and cultured on MS medium ( Murashige and Skoog medium) supplemented with 0.5 mg/L TDZ (thidiazuron) and cholesterol at the concentrations 0.0, 0.1, 0.3, 0.5, 1.0, 1.5, 2.0 or 4.0 mg/L. After 45 day, results showed that the treatment with 0.5 mg/L TDZ and 2.0mg/L cholesterol had a positive effected on increasing the dry weight of multiplied shoots and their production of digitonin when compared with other treatments, where this treatment gave 2.98 g dry weight of multiplied shoots and digitonin at amount of 64.42 mg/g dry weight, while the other studied characteristics of multiplied shoots (content the total chlorophyll, soluble sugars and starch.) also this treatment had appositive effected and was gave the following values:- (3.51 mg/g fresh weight, 5.06% ,6.09% ) respectively. After that experiment 2 was carried out . The objective of this experiment was to increase the degree of digitonin production in multiplied shoots compared with the experiment 1.Therfore in the experiment 2, we were selected supplements the best treatment of experiment 1(0.5mg /L TDZ and 2.0mg/ L cholesterol ) and supplemented to the MS medium with the sugars glucose, fructose, sucrose or maltose at the concentrations 30,50,70 or 90 g/L for each sugar. After 45 days results showed that the treatment with 0.5 mg/L TDZ, 2.0 mg/L cholesterol and 50g/L maltose was the best a compared with other treatments, where this treatment gave 4.52 g dry weight of multiplied shoots and digitonin at amount of 191.87 mg/g dry weight . The content of multiplied shoots from the total chlorophyll, soluble sugars and starch also this treatment gave highest values and they are 4.97 mg/g fresh weight , 5.91% and 8.30% respectively .
Key words: Digitalis purpurea, Cholesterol, Sugars, Digitonin .
Phytochemical Study of some Flavonoids Present in the Fruits of Two Ammi L. Species Wildly Grown in Iraq
Authors: Z. Abdul-Jalil Thukaa , Saour Kawkab , Nasser Abdul- MutalibA. 
Published: March 2022

Ammi species belong to the family Umbellifereae that provide a host of bioactive compounds (mainly coumarins and flavonoids) of important biological activities, like prevention and treatment of heart and vascular disease and some types of cancer. Literature survey revealed that there was no study concerning Ammi flavonoids in Iraq. Ammi majus and Ammi visnaga, which are wildly grown in Iraq, were chosen for this study. This study concerned with extraction, identification, isolation, and purification of some biologically important flavonols quercetin and kaempferol from the fruits of Ammi majus and Ammi visnaga. Extraction of these flavonols was carried out using 85% methanol and 90% ethanol. Identification of these flavonols quercetin and kaempferol was done using thin Layer chromatography (TLC) where different solvent systems had been tried. Ultra violet (UV) Light and iodine vapor where used for detection. This identification was further augmented by using high performance Liquid chromatography (HPLC) and then these flavonols were isolated and purified. The most suitable extraction, isolation and purification procedures of flavonols were fully described in this study. The identification of isolated flavonols (quercetin & kaempferol) was carried out using melting point (M.P.), Thin Layer chromatography (TLC), and infrared spectroscopy (IR).This study confirms the presence of quercetin and kaempferol in Ammi majus & an Ammi visnaga fruit, the percentage of quercetin was higher in Ammi visnaga than Ammi majus, while the percentage of kaempferol was higher in Ammi majus than Ammi visnaga.
Key words : Ammi majus , Ammi visnaga , quercetin , kaempferol .
METABOLIC CHANGES IN WOMEN AND MEN WITH TYPE 2 DM ON ISLGT-2 TREATMEN
Authors: Prybyla O.V.  , Zinych O.V.  , Kushnarova N.M.  , Kovalchuk A.V.  , Korpachev V.V  , Shuprovych A.A.  , Shyshkan-Shyshova K.O.  
Published: March 2022

The use of morpho-metabolic approaches has a great practical importance in evaluation of the effectiveness of antihyperglycemic therapy in clinical trials, in particular those related to new classes of inhibitors of sodiumdependent glucose-2 cotransporter inhibitors that have the ability to counteract many diabetic complications and cardiovascular disease. The aim of the study was to study the effect of treatment with SLGT2 inhibitors on morphological and metabolic parameters in men and women with type 2 diabetes. Materials and methods. During the study, 205 patients with type 2 diabetes, aged 30 to 81, with a disease duration of 1 to 20 years were examined. Patients underwent a clinical examination in the Department of Age Endocrinology and Clinical Pharmacology of the Institute of Endocrinology and Metabolism. V.P. Komissarenko of the National Academy of Medical Sciences of Ukraine. Patients received antihyperglycemic, antihypertensive and dyslipidemic therapy. Results.The study of anthropometric, morphological and biochemical parameters in groups of men and women with type 2 diabetes in the dynamics of longterm (12 month) use of iSLGT2- dapagliflozin allowed to identify certain sexual characteristics of the effects of this drug. In men group have been seen a gradual decrease in visceral fat levels during therapy. A decrease in BMI, BP, body weight and uricemia in men is most likely associated with a decrease in abdominal obesity and decreased insulin secretion. In women group use of dapagliflozin showed a significant decrease in total and visceral fat, accompanied by a decrease in relative water content, muscle and bone mass. Conclusions. Treatment of patients with type 2 diabetes with drugs of the group iSLGT2 for 12 months has reduced the degree of obesity and improved some indicators of body composition, uric acid.
A taxonomy for brainstem cavernous malformations: subtypes of pontine lesions. Part 2: inferior peduncular, rhomboid, and supraolivary
Authors: Catapano Joshua S. , Rumalla Kavelin , Srinivasan Visish M. , Lawrence Peter M. , Larson Keil Kristen , Lawton Michael T. 
Published: March 2022

OBJECTIVE
Part 2 of this 2-part series on pontine cavernomas presents the taxonomy for subtypes 4–6: inferior peduncular (IP) (subtype 4), rhomboid (5), and supraolivary (6). (Subtypes 1–3 are presented in Part 1.) The authors have proposed a novel taxonomy for pontine cavernous malformations based on clinical presentation (syndromes) and anatomical location (MRI findings).

METHODS
The details of taxonomy development are described fully in Part 1 of this series. In brief, pontine lesions (323 of 601 [53.7%] total lesions) were subtyped on the basis of predominant surface presentation identified on preoperative MRI. Neurological outcomes were assessed according to the modified Rankin Scale, with score ≤ 2 defined as favorable.

RESULTS
The 323 pontine brainstem cavernous malformations were classified into 6 distinct subtypes: basilar (6 [1.9%]), peritrigeminal (53 [16.4%]), middle peduncular (100 [31.0%]), IP (47 [14.6%]), rhomboid (80 [24.8%]), and supraolivary (37 [11.5%]). Subtypes 4–6 are the subject of the current report. IP lesions are located in the inferolateral pons and are associated with acute vestibular syndrome. Rhomboid lesions present to the fourth ventricle floor and are associated with disconjugate eye movements. Larger lesions may cause ipsilateral facial weakness. Supraolivary lesions present to the surface at the ventral pontine underbelly. Ipsilateral abducens palsy is a strong localizing sign for this subtype. A single surgical approach and strategy were preferred for subtypes 4–6: for IP cavernomas, the suboccipital craniotomy and telovelar approach predominated; for rhomboid lesions, the suboccipital craniotomy and transventricular approach were preferred; and for supraolivary malformations, the far lateral craniotomy and transpontomedullary sulcus approach were preferred. Favorable outcomes were observed in 132 of 150 (88%) patients with follow-up. There were no significant differences in outcomes between subtypes.

CONCLUSIONS
The neurological symptoms and signs associated with a hemorrhagic pontine subtype can help define that subtype clinically with key localizing signs. The proposed taxonomy for pontine cavernous malformation subtypes 4–6 meaningfully guides surgical strategy and may improve patient outcomes.
Monitoring of compressed air losses in branched air flow networks of mining enterprises
Authors: Gendler Semen , Kopachev Valeriy , Kovshov Stanislav 
Published: March 2022

Compressed air as a type of safe technological energy carrier is widely used in many industries. In economically developed countries energy costs for the production and distribution of compressed air reach 10 % of the total energy costs. The analysis of compressed air production and distribution systems in the industrial sector shows that the efficiency of the systems is at a relatively low level. This is due to the fact that insufficient attention is paid to these systems since the compressed air systems energy monitoring has certain difficulties – the presence of complex and branched air pipeline networks with unique characteristics; low sensitivity of the equipment which consumes compressed air; the complexity of auditing pneumatic equipment that is in constant operation. The article analyzes the options for reducing the cost of production and compressed air distribution. One of the promising ways to reduce the compressed air distribution cost is timely detection and elimination of leaks that occur in the external air supply network of the enterprise. The task is solved by hardware-software monitoring of compressed air pressure at key points in the network. The proposed method allows real-time detecting of emerging air leaks in the air duct network and sending commands to maintenance personnel for their timely localization. This technique was tested in the industrial conditions of ALROSA enterprises on the air pipeline network of the Mir mine of the Mirninsky Mining and Processing Plant and showed satisfactory convergence of the calculated leakage values ​​with the actual ones. The practical significance of the obtained results is that the developed method for monitoring air leaks in the air duct network is simple, it requires an uncomplicated software implementation and allows to localize leaks in a timely manner, thereby reducing unproductive energy costs at the enterprises.
Dry Eye Syndrome in Patients of Diabetes with and without Diabetic Retinopathy
Authors: Khurana Sunita , Arora Prem Kumar 
Published: March 2022

Background: The present study was done to assess dry eye syndrome in patients with and without diabetic retinopathy. We compared symptoms and signs of dry eye syndrome in patients with and without retinopathy
Methods: The study was conducted on cases of Type 2 diabetes mellitus with age ?35 years. The study participants were divided into two distinct groups. First group consists of diabetic patients with clinical evidence of diabetic retinopathy and second group with no evidence of diabetic retinopathy. 50 patients were enrolled in each of the above two groups after written informed consent.
Results: All Signs of dry eye disorder were found more commonly in patients with diabetic retinopathy(42.00%) as compared to those without diabetic retinopathy(18.00%).
Conclusion: Dry eye syndrome was positively correlated with the presence of diabetic retinopathy in this study. Any diabetic patient complaining of dry eye symptoms should be screened for diabetic retinopathy.
Keywords: Dry eye, Diabetes, Retinopathy
To Study the Dry Eye Prevalence Following Phacoemulsification Surgery
Authors: Rajvanshi Seema , Khurana Sunita 
Published: March 2022

Background: To study dry eye following phacoemulsification surgery
Methods: This prospective observational study was performed after selecting 100 consecutive patients over 45 years of age with senile cataract, without preexisting dry eye and other ocular disorders.
Results: All the tests performed preoperatively and postoperatively showed incidence of dry eye to be 10.00%.
Conclusion: We concluded that cataract surgery can cause dry eye. However, before surgery, preoperative assessment of all patients should be done properly. Patients must be informed about the possible occurrence of dry eye symptoms postoperativelyand should be managed accordingly.
Keywords: Dry Eye, Phacoemulsification surgery, Tear Film Break Up Time
Efficacy and Safety of Low Dose Atropine 0.01% in Slowing of Progression of Myopia
Authors: Rajvanshi Seema , Khurana Sunita 
Published: March 2022

Background: We conducted this study to evaluate the efficacy & safety of topical 0.01% atropine eye drops in slowing down the progression of myopia and axial length elongation.
Methods: In this study had 50 patients ( 100 eyes) divided in two groups , 25 patients (50 eyes) in interventional groups and 25 patients (50 eyes) in control group.
Results: Autorefrectometer (AR) readings change from base line 2.11±0.11D to after 12 month 2.09±0.12D so increases in AR reading was –0.02D in interventional group at one year follow up. AR reading changes from baseline 2.16±0.12D to after 12 month 2.22±0.18D so increases in AR reading was -0.06D in control groups. Subjective refraction changed from base line 2.01±0.06D to after 12 month 2.91±0.11D so increases in Subjective refraction was +0.9D in cases at one year follow up. Subjective refraction changed from base line 2.03±0.05D to after 12 month 3.23±0.18D so increases in subjective refraction were +1.2D in control group at one year follow up.
Conclusion: Low-dose (0.01%) topical atropine eye drops treatment was a safe and effective method for slowing down the progression of myopia in children and adolescents because it has growth suppressing influence by acting on extraretinal muscarinic receptors possible in the retinal pigment epithelium, choroid and sclera.
Keywords: Myopia, Atropine, Subjective refraction, Autorefrectometer.
Santri-Entrepreurs and Development of Community-Based Batik Industry at Laweyan, Solo, Indonesia
Authors: Lubis Sahruddin , Zamharir Hari 
Published: March 2022

Though studies on the relationship between worldly asceticism and economic progress is an old thing, this study presents a re-visit of Boeke’s Indonesia dual economy as a result of the presence of a mixture of such a duality performed by Santri-entrepreneurs at Laweyan, Solo, Indonesia. Industrialism as a way of life is commonly linked to the transformation from agricultural societies into industrial in modern West nations, with the crucial roles of industrial entrepreneurs who were among the few in the respective societies having distinctive personal qualities. The most well-known thesis was Weber’s thesis on the relationship between the Protestant ethic and economic development by the few entrepreneurs possessing worldly asceticism—homo economicus who were working hard for achieving material well-being but at the same time develop religious ascetic life. The paper makes an account of Islam-based Santri-entrepreneurs in Kampung Batik Laweyan (KBL), Solo, Indonesia, employing a critically theoretical perspective of Max Weber and Boeke; the study takes into account political context and socio-cultural setting. It is our findings that Santri-entrepreneurs at KBL developed worldly asceticism, but political context has made the unstable growth of the business; contemporary steady growth has been made possible by the provision of the concept KBL as Cultural Heritage and facilitation by the local government, especially the establishment of deliberation forum among several parties that gives ample room for their steady growth.
Cancer risk among World Trade Center rescue and recovery workers: A review
Authors: Boffetta Paolo , Hall Charles B. , Todd Andrew C. , Goldfarb David G. , Schymura Maria J. , Li Jiehui , Cone James E. , Zeig‐Owens Rachel 
Published: March 2022

AbstractTwenty years after the September 11th, 2001 terrorist attacks, the association between exposures present at the World Trade Center (WTC) site and the risk of several specific types of cancer has been reported among rescue and recovery workers. The authors' objective was to conduct an updated review of these data. Most studies have found elevated rates of both prostate and thyroid cancers compared with rates in the general population, and some have reported statistically significant differences for the rates of all cancers as well. Studies including a larger combined cohort of WTC‐exposed rescue and recovery workers from 3 main cohorts have since replicated findings for these cancers, with additional years of follow‐up. Among this combined cohort, although a lower‐than‐expected standardized incidence ratio for all cancers was observed, WTC exposure was also related to an increased risk of cutaneous melanoma and tonsil cancer. Importantly, another study found that WTC‐exposed rescue and recovery workers who are enrolled in the federally funded medical monitoring and treatment program experienced improved survival post‐cancer diagnosis compared with New York state patients with cancer. On the basis of these combined cohort studies, the full effect of WTC exposure on cancer risk is becoming clearer. Consequently, the authors believe that surveillance of those with WTC exposure should be continued, and in‐depth analysis of epidemiologic, molecular, and clinical aspects of specific cancers in these workers should be pursued.
Elämää vaalivan itsekasvatuksen luonnos
Authors: Kallio Johanna , Pulkki Jani 
Published: March 2022

Tarkastelemme artikkelissa itsekasvatusta, eli omaehtoista, itseen kohdistuvaa kasvatustyötä aktivistisena pyrkimyksenä vastata aikamme ekokriiseihin ihmisen sisäisen muutoksen näkökulmasta. Itsekasvatus ymmärretään artikkelissa suomalaisen perinteen ja erityisesti kasvatusfilosofi Juho August (J. A.) Hollon (1885–1967) teoriaan perustuvana kasvatustoimintana, jonka tavoitteena on elämisen taidon eli merkityksellisen elämän löytäminen. Hollon mukaan elämän vaaliminen kaikissa muodoissaan on ihmiselle tärkeää, sillä kaikessa kasvavassa – niin kasveissa, luonnossa, eläimissä kuin mikro-organismeissa – on samaa elämänvoimaa. Holistisessa, ihmisen ja ei-ihmisen yhteyttä painottavassa ajattelussaan Hollo oli monia aikalaisiaan edellä. Kehitämme elämää vaalivaa itsekasvatusajattelua, joka yhdistää Hollon itsekasvatuksen teorian Martha C. Nussbaumin (1947–) itsekasvatusajatteluun. Hollon teoria on elämää vaalivan itsekasvatuksen lähtökohta, johon Nussbaumin teoria tarjoaa konkreettisen itsekasvatuksen harjoittamisen tavan. Nussbaumin teoria laajentaa Hollon itsekasvatuskäsitystä erityisesti tunnetyön ja tunteiden filosofisen käsittelyn näkökulmasta ja on siten käytännön esimerkki itsekasvatuksen tavasta. Kehittämämme elämää vaalivan itsekasvatuksen synteesin ensisijainen tavoite on tarjota itsekasvatuksen malli ekologisesti kestävämmän ajattelun kehittämiseen ja toiminnan muuttamiseen.
Mobile Apps Design to Find Internship Place Using Design Thinking Method
Authors: Ramadhan Hanan Afif , Fitriana Gita Fadila 
Published: March 2022

Magang menjadi kegiatan wajib sebagai mahasiswa di Institut Teknologi Telkom Purwokerto. Namun dengan banyaknya media pencari tempat kerja untuk magang dalam penerapannya, mahasiswa masih kesulitan mencari tempat magang yang cocok. Penelitian ini bertujuan untuk menerapkan Design Thinking dan System Usability Scale untuk merancang tampilan antarmuka aplikasi untuk mencari tempat magang. Tinjauan pustaka digunakan untuk menemukan dasar penelitian yang digunakan sebagai teori, konsep dasar, dan metode. Design Thinking dilakukan untuk menemukan suatu permasalahan yang dihadapi mahasiswa. Validasi masalah dilakukan dengan melakukan survei. Dan memprioritaskan masalah menggunakan matriks tantangan. Prototipe dilakukan dengan membuat desain yang dapat dicoba oleh pengguna untuk mencapai tujuan dari desain yang dibuat dan menguji tingkat keberhasilan menggunakan skala system usability scale. Hasil dari penelitian ini adalah rancangan antarmuka aplikasi mobile yang diuji menggunakan skala system usability scale dengan 8 data uji dan memiliki tingkat keberhasilan dengan nilai 93,75%. Perancangan antarmuka yang dibuat dapat membantu mahasiswa menemukan tempat magang yang paling sesuai dengan kemampuan dan keinginannya.
Estudos in vitro, in vivo e in sílico de alcaloides frente a Giardia Lâmblia
Authors: Nascimento Daniela Macedo , Nascimento Ademir Macedo 
Published: March 2022

A técnica In Silico seleciona e otimiza a escolha dos melhores processos em uma matriz de interesse, já o estudo In Vitro é realizado em placas de Petri com culturas celulares. O estudo In Vivo proporciona mensurar os efeitos da espécie a ser estudada. Neste caso, o alcalóide será injetado tanto nas culturas celulares como nos estudos in vivo, para indicar toxicidade, eficiência e seus efeitos posteriores. Serão analisados alcalóides ou outros tipos de compostos que geram fármacos. Os alcalóides são metabólitos secundários que se caracterizam por serem uma estrutura cíclica com nitrogênio e par de elétrons livres, sendo muito reativos e apresentando aplicações nas áreas farmacêuticas e medicinais. A Giárdia Lamblia é um protozoário patogênico cuja transmissão é por intermédio de água e alimentos contaminados, sendo responsável pela doença giardíase, que apresenta alguns sintomas como dores abdominais, diarreia e causa milhões de mortes por ano em todo o mundo.
Assistência de enfermagem ao paciente com infarto agudo do miocárdio
Authors: Aguiar Alana Luísa Carvalho , Ribeiro Wanatha Jhenifer Sousa , Melo Thiago Teles de Medeiros , Silva Patrício Francisco da , Melo Rodrigo Teles de Medeiros , Lima Lailton de Sousa , Silva Raylton Aparecido Nascimento , Abreu Vitor Pachelle Lima , Lima Thiago Oliveira Sabino , Abrão Ruhena Kelber 
Published: March 2022

O infarto é uma patologia que afeta ainda milhões da população. O presente estudo objetivou descrever a assistência de enfermagem ao paciente com diagnóstico de infarto agudo do miocárdio, bem como relatar assistência de enfermagem ao paciente com diagnóstico de infarto agudo do miocárdio e discorrer sobre a fisiopatologia desencadeada nesta patologia. Metodologicamente trata-se de uma revisão da literatura no estilo narrativo com busca dos artigos publicados entre 2007 a 2016, indexados nas bases de dados, Recien, Reufpi, SciELO, Bireme, Lilacs, etc. Como resultados, os diagnósticos de enfermagem corroboram para análise das respostas diretas e indiretas ao infarto do miocárdio. A conduta de enfermagem ao paciente infartado exige capacitação e competência técnica para detecção e atuação imediata nesta situação. A conclusão deste estudo mostra que as ações de enfermagem frente a pacientes com IAM são indispensáveis, mas que essas ações são mais eficazes quando há uma ação conjunta de multiprofissionais atuando na promoção, prevenção, intervenções e assistência para evitar complicações e agravamento da doença. Este estudo demonstra a importância da assistência de enfermagem diante deste agravo, bem como subsidiar novas pesquisas na área acadêmica para fortalecimento e reflexões aos profissionais de saúde.