bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postprocessing Ensemble Weather Forecasts for Introducing Multisite and Multivariable Correlations Using Rank Shuffle and Copula Theory
Authors: Chen Jie , Li Xiangquan , Xu Chong-Yu , Zhang Xunchang John , Xiong Lihua , Guo Qiang 
Published: January 2022

Abstract
Statistical methods have been widely used to postprocess ensemble weather forecasts for hydrological predictions. However, most of the statistical postprocessing methods apply to a single weather variable at a single location, thus neglecting the intersite and intervariable dependence structures of forecast variables. This study synthesized a multisite and multivariate (MSMV) postprocessing framework that extends the univariate method to the MSMV version by directly rearranging the postprocessed ensemble members (post-reordering strategy) or by rearranging the latent variables used in the univariate method (pre-reordering strategy). Based on the univariate generator-based postprocessing (GPP) method, the two reordering strategies and three dependence reconstruction methods [rank shuffle (RS), Gaussian copula (GC), and empirical copula (EC)] totaling six MSMV methods (RS-Pre, GC-Pre, EC-Pre, RS-Post, GC-Post, and EC-Post) were evaluated in postprocessing ensemble precipitation and temperature forecasts for the Xiangjiang basin in China using the 11-member ensemble forecasts from the Global Ensemble Forecasting System (GEFS). The results showed that raw GEFS forecasts tend to be biased for both the forecast ensembles and the intersite and intervariable dependencies. The univariate method can improve the univariate performance of ensemble mean and spread but misrepresent the intersite and intervariable dependence among the forecast variables. The MSMV framework can well utilize the advantages of the univariate method and also reconstruct the intersite and intervariable dependencies. Among the six methods, RS-Pre, RS-Post, GC-Post, and EC-Post perform better than the others with respect to reproducing the univariate statistics and multivariable dependences. The post-reordering strategy is recommended to combine the univariate method (i.e., GPP) and reconstruction methods.
Blood pressure and cognitive function among older adults in India
Authors: Farron Madeline R. , Kabeto Mohammed U. , Levine Deborah A. , Wixom Caroline R. , Langa Kenneth M. 
Published: January 2022

Objective We aimed to investigate the relationship between blood pressure and cognitive function among older adults in India. Methods In this study, we analyzed cross-sectional data of systolic and diastolic blood pressure (SBP and DBP, respectively) and cognitive testing from 3690 adults aged 60 years and older participating in the Longitudinal Aging Study in India—Diagnostic Assessment of Dementia from 14 states in India. Results After controlling for key sociodemographic, health, and geographic factors, higher SBP and lower DBP were each independently associated with worse cognitive function. Older age, female sex, lower education level, being widowed, residing in a rural area, being a member of a Scheduled Caste or Scheduled Tribe, having a low level of economic consumption, being underweight, and a history of stroke were all independently associated with worse cognitive function scores. Conclusions Both SBP and DBP were independently associated with cognitive function among older adults in India in diverging directions. Clinical interventions targeting high SBP and low DBP may benefit both cognitive health and cardiovascular health.
Advance prediction method for rock mass stability of tunnel boring based on deep neural network of time series
Authors: Junzhou Huo , Guopeng Jia , Bin Liu , Shiwu Nie , Junbo Liang , Hanyang Wu 
Published: January 2022

Geological layers excavated using tunnel boring machines are buried deeply and sampled difficultly, and the geological behavior exhibits high diversity and complexity. Excavating in uncertain geology conditions bears the risks of excessive damage to the equipment and facing geologic hazards. Many scholars have used various signals to predict the advance geology conditions, but accurate prediction of these conditions in real-time and without effecting operations has not been realized yet. In this article, based on a large amount of corresponding data, an advance prediction model of the rock mass category (RMC) is formulated. First, the problem is divided into two parts, which are modeled separately to reduce the complexity of design and training. Then, the two models are combined in a pre-trained model, which is retrained to as the final prediction model to avoid the problem of error accumulation. The final model can predict the advance RMC in real-time and without affecting operations. The accuracy of the prediction model reaches 99% at an advance time of 60 min. The advance RMC can be used to guide the selection of support modes and control parameters without additional detection equipment and excavation down-time.
The evidence for introducing case-finding for delirium and dementia in older medical inpatients in a New Zealand hospital
Authors: Cullum Sarah , Kubba Yezen , Varghese Chris , Coomarasamy Christin , Hopkins John 
Published: January 2022

Objective The aim of this project was to make the case to the managers of a large urban teaching hospital in New Zealand for the introduction of systematic case-finding for pre-existing cognitive impairment/dementia in older hospital inpatients that screen positive for delirium. Method Two hundred consecutive acute admissions aged 75+ in four medical wards were assessed using the 4AT assessment tool for delirium and the Alzheimer Questionnaire (AQ) for pre-existing cognitive impairment/dementia. Length of stay and mortality at 1 year were also collected. Results Over a third of the sample screened positive for delirium and nearly two-thirds of these also screened positive for dementia. The median length of stay was 5 days for delirium without dementia and 7 days for delirium with dementia, compared to 3 days for those who screened negative for both. After adjustment for age, gender and ethnic group, people who screened positive for delirium (with or without dementia) had 50% longer length of stay ( p < 0.05) and at least double the risk of death ( p < 0.05). Conclusion Older hospital inpatients that screen positive for delirium and dementia using 4AT and AQ have longer lengths of stay and higher mortality. Identification may lead to more timely interventions that help to improve health outcomes and reduce hospital costs.
Adapting Elements of Cleft Care Protocols in Low- and Middle-income Countries During and After COVID-19: A Process-driven Review With Recommendations
Authors: Fell Matthew , Goldwasser Michael , Jayanth B.S. , Pereira Rui Manuel Rodrigues , Nawej Christian Tshisuz , Winer Rachel , Daftari Neeti , Brewster Hugh , Goldschmied Karen , Almas Collaborators: Fernando , Eshete Mekonen , Galiwango George W. , Hollier Larry H. , Hussain Akhter , Lo Lun-Jou , Salins Paul , Sell Debbie , Tafase Amanuel , Zuker Ronald M. 
Published: January 2022

A consortium of global cleft professionals, predominantly from low- and middle-income countries, identified adaptations to cleft care protocols during and after COVID-19 as a priority learning area of need.A multidisciplinary international working group met on a videoconferencing platform in a multi-staged process to make consensus recommendations for adaptations to cleft protocols within resource-constrained settings. Feedback was sought from a roundtable discussion forum and global organizations involved in comprehensive cleft care.Foundational principles were agreed to enable recommendations to be globally relevant and two areas of focus within the specified topic were identified. First the safety aspects of cleft surgery protocols were scrutinized and COVID-19 adaptations, specifically in the pre- and perioperative periods, were highlighted. Second, surgical procedures and cleft care services were prioritized according to their relationship to functional outcomes and time-sensitivity. The surgical procedures assigned the highest priority were emergent interventions for breathing and nutritional requirements and primary palatoplasty. The cleft care services assigned the highest priority were new-born assessments, pediatric support for children with syndromes, management of acute dental or auditory infections and speech pathology intervention.A collaborative, interdisciplinary and international working group delivered consensus recommendations to assist with the provision of cleft care in low- and middle-income countries. At a time of global cleft care delays due to COVID-19, a united approach amongst global cleft care providers will be advantageous to advocate for children born with cleft lip and palate in resource-constrained settings.
Tyrosine kinase inhibitor nilotinib induced palmoplantar erythrodysesthesia: A rare case
Authors: Aslaner Ak Muzeyyen , Ertop Doğan Pelin , Sahip Birsen 
Published: January 2022

Introduction Nilotinib is a second generation Tyrosine Kinase inhibitor (TKI) used in the treatment of Chronic Myeloid Leukemia (CML). The development of tyrosine kinase inhibitors has transformed chronic phase chronic myeloid leukemia from a disease with a poor prognosis to a treatable chronic disease. Long-term treatment with tyrosine kinase inhibitors means that patients must be clinically managed and monitored for years. While under Nilotinib tretament, the development of palmoplantar erythrodyesthesia is a very rare condition compared to other oncological drugs. Case report A 66-year-old male patient, who was diagnosed with chronic phase CML in 2019 had been placed under imatinib treatment . He had major molecular response loss in 2021, and was started on second generation TKI nilotinib 2  ×  400mg/day, considering his comorbidities. We present a case of a 66-year-old patient with CML who developed palmoplantar erythrodysesthesia on the 21st day starting nilotinib treatment. Conclusion It is important to manage the side effects that develop in long-term treatments. Adverse events can have a negative impact on patient compliance and quality of life and lead to poor clinical outcomes Our case is the first to develop PPE after beginning nilotinib use. We present this phenomenon to raise awareness and ignite a review of management strategies.In this case, we wanted to emphasize the importance of managing side effects.
Social campaigns to social change? Sexual violence framing in U.S. news before and after #metoo
Authors: Noetzel Selina , Mussalem Gentile Maria F , Lowery Gianna , Zemanova Sona , Lecheler Sophie , Peter Christina 
Published: January 2022

The discussion on sexual violence gained momentum in October 2017 after the Twitter hashtag (#metoo) spread globally highlighting the widespread reality of this problem. While this resulted in extensive media coverage, and naturally informed audiences about societal issues, it can also be problematic regarding the media’s power to reflect and construct reality. Therefore, it is important to research how societal issues like sexual violence are discussed in media settings. The study aimed to investigate how journalists frame sexual violence in the news (RQ1) and whether such practices have changed in the wake of the MeToo movement (RQ2). A quantitative content analysis was conducted for news articles published in four US newspapers, spanning a period of 2 years – from 1 year before to 1 year after the #metoo tweet ( N = 612; Oct. 2016 – Oct. 2018). Results indicate that news coverage on sexual violence shifted from straightforward, single-incident reports to broader discussions. This study contributes to scientific research and journalism practices by providing an overarching view of how sexual violence is framed in the news and the potential impact of social movements on reportage.
Modifiable risk factors for intracranial aneurysms: Evidence from genetic studies
Authors: Sun Xiaohui , Liu Bin , Chen Ying , Lv Linshuoshuo , Ye Ding , Mao Yingying 
Published: January 2022

Background: Intracranial aneurysm (IA) is a crucial health concern with limited strategies for prevention and treatment. Aim: To identify potentially modifiable risk factors, such as socioeconomic, behaviors, dietary, and cardiometabolic factors, for IA and its subtypes. Methods: Summary statistics for IA were derived from a genome-wide association study with an overall 79,429 participants. Single nucleotide polymorphisms associated with modifiable risk factors at genome-wide significance ( P = 5 × 10–8) were used as instrumental variables. The inverse-variance-weighted method, weighted-median method, Mendelian randomization (MR)-Egger regression, MR-Pleiotropy RESidual Sum and Outlier, and multivariable MR analyses were performed to evaluate the effect estimates. Results: Genetically predicted educational attainment, insomnia, smoking, and systolic and diastolic blood pressure (SBP and DBP) were significantly associated with the risk of IA. The odds ratios (ORs) were 0.44 (95% confidence interval (CI): 0.37–0.52) for educational attainment, 1.15 (95% CI: 1.08–1.23) for insomnia, 1.56 (95% CI: 1.38–1.75) for smoking initiation, 2.69 (95% CI: 1.77–4.07) for cigarette per day, 2.65 (95% CI: 1.72–4.08) for lifetime smoking, 1.07 (95% CI: 1.06–1.09), and 1.06 (95% CI: 1.04–1.10) for SBP and DBP, respectively. Similar effect estimates were observed for unruptured IAs and aneurysmal subarachnoid hemorrhage. Conclusions: This study provided genetic evidence that several modifiable risk factors, including blood pressure, smoking, educational attainment, and insomnia were associated with the risk of IA.
Effects of Deficits in the Neuromuscular and Mechanical Properties of the Quadriceps and Hamstrings on Single-Leg Hop Performance and Dynamic Knee Stability in Patients After Anterior Cruciate Ligament Reconstruction
Authors: He Xin , Qiu Jihong , Cao Mingde , Ho Yui Chung , Leong Hio Teng , Fu Sai-Chuen , Ong Michael Tim-Yun , Fong Daniel T.P. , Yung Patrick Shu-Hang 
Published: January 2022

Background: Understanding the role of neuromuscular and mechanical muscle properties in knee functional performance and dynamic knee stability after anterior cruciate ligament reconstruction (ACLR) may help in the development of more focused rehabilitation programs. Purpose: To compare the involved and uninvolved limbs of patients after ACLR in terms of muscle strength, passive muscle stiffness, muscle activation of the quadriceps and hamstrings, hop performance, and dynamic knee stability and to investigate the association of neuromuscular and mechanical muscle properties with hop performance and dynamic knee stability. Study Design: Cross-sectional study; Level of evidence, 3. Method: The authors studied the quadriceps and hamstring muscles in 30 male patients (mean ± SD age, 25.4 ± 4.1 years) who had undergone unilateral ACLR. Muscle strength was measured using isokinetic testing at 60 and 180 deg/s. Passive muscle stiffness was quantified using ultrasound shear wave elastography. Muscle activation was evaluated via electromyographic (EMG) activity. Hop performance was evaluated via a single-leg hop test, and dynamic knee stability was evaluated via 3-dimensional knee movements during the landing phase of the hop test. Results: Compared with the uninvolved limb, the involved limb exhibited decreased peak torque and shear modulus in both the quadriceps and hamstrings as well as delayed activity onset in the quadriceps ( P < .05 for all). The involved limb also exhibited a shorter hop distance and decreased peak knee flexion angle during landing ( P < .05 for both). Decreased peak quadriceps torque at 180 deg/s, the shear modulus of the semitendinosus, and the reactive EMG activity amplitude of the semimembranosus were all associated with shorter hop distance ( R 2 = 0.565; P < .001). Decreased quadriceps peak torque at 60 deg/s and shear modulus of the vastus medialis were both associated with smaller peak knee flexion angle ( R 2 = 0.319; P < .001). Conclusion: In addition to muscle strength deficits, deficits in passive muscle stiffness and muscle activation of the quadriceps and hamstrings were important contributors to poor single-leg hop performance and dynamic knee stability during landing. Further investigations should include a rehabilitation program that normalizes muscle stiffness and activation patterns during landing, thus improving knee functional performance and dynamic knee stability.
Lysosomal iron recycling in mouse macrophages is dependent upon both LcytB and Steap3 reductases
Authors: Meng Fanjing , Fleming Brittany A. , Jia Xuan , Rousek Alexis A. , Mulvey Matthew A. , Ward Diane M. 
Published: January 2022

Abstract
Iron that is stored in macrophages as ferritin can be made bioavailable by degrading ferritin in the lysosome and releasing iron back into the cytosol. Iron stored in ferritin is found as Fe3+ and must be reduced to Fe2+ before it can be exported from the lysosome. Here we report that the lysosomal reductase Cyb561a3 (LcytB) and the endosomal reductase six-transmembrane epithelial antigen of prostate 3 (Steap3) act as lysosomal ferrireductases in the mouse macrophage cell line RAW264.7 converting Fe3+ to Fe2+ for iron recycling. We determined that when lysosomes were loaded with horse cationic ferritin, reductions or loss of LcytB or Steap3 using CRISPR/Cas9-mediated knockout technology resulted in decreased lysosomal iron export. Loss of both reductases was additive in decreasing lysosomal iron export. Decreased reductase activity resulted in increased transcripts for iron acquisition proteins DMT1 and transferrin receptor 1 (Tfrc1) suggesting that cells were iron limited. We show that transcript expression of LcytB and Steap3 is decreased in macrophages exposed to Escherichia coli pathogen UTI89, which supports a role for these reductases in regulating iron availability for pathogens. We further show that loss of LcytB and Steap3 in macrophages infected with UTI89 led to increased proliferation of intracellular UTI89 suggesting that the endolysosomal system is retaining Fe3+ that can be used for proliferation of intravesicular pathogens. Together, our findings reveal an important role for both LcytB and Steap3 in macrophage iron recycling and suggest that limiting iron recycling by decreasing expression of endolysosomal reductases is an innate immune response to protect against pathogen proliferation and sepsis.
LncRNA HCG18 upregulates TRAF4/TRAF5 to facilitate proliferation, migration and EMT of epithelial ovarian cancer by targeting miR-29a/b
Authors: Zhang Fan , Luo Bai-Hua , Wu Qi-Hui , Li Qing-Ling , Yang Ke-Da 
Published: January 2022

Abstract
Background
Although long noncoding RNA HLA complex group 18 (lncRNA HCG18) has been suggested to regulate cell growth in several tumours, the function of HCG18 in epithelial ovarian cancer (EOC) and its mechanism are still unclear.

Methods
shRNAs were applied to reduce HCG18 and related genes. For overexpression of miRNA, a miRNA mimic was transfected into cells. Quantitative real-time PCR (qRT–PCR) was used to detect levels of HCG18, miR-29a/b, and mRNAs. MTT, colony formation, wound healing and Transwell assays were used to evaluate cell proliferation, migration and invasion, respectively. A luciferase reporter assay was utilized to evaluate NF-κB activity and the binding of miRNAs with HCG18 or TRAF4/5. BALB nude mice injected with cells stably expressing shHCG18 or shNC were used for in vivo modelling. Subcutaneous tumour growth was monitored in nude mice, and immunohistochemistry (IHC) was used to determine expression of the proliferation marker Ki67.

Results
Abnormal expression of HCG18 and miR-29a/b was observed in EOC tissues. Knockdown of HCG18 using shRNA inhibited proliferation, migration, EMT and the proinflammatory pathway in EOC cells. miR-29a/b mimics and TRAF4/5 knockdown exhibited effects similar to HCG18 knockdown. Further experiments suggested that HCG18 directly targets miR-29a/b and upregulates TRAF4/5 expression, which are inhibited by targeting miR-29a/b. Moreover, overexpression of TRAF4/5 antagonized the inhibitory effect of HCG18 knockdown, suggesting that they are involved in HCG18-mediated oncogenic effects. Silencing HCG18 reduced tumour size and levels of Ki67 and TRAF4/5 while increasing miR-29a/b levels in vivo.

Conclusions
Taken together, our data revealed an oncogenic signalling pathway mediated by HCG18 in ovarian cell lines, which functions as a ceRNA of miR-29a/b and thus derepresses expression levels of TRAF4/5, facilitating NF-κB pathway-mediated promotion of EOC cell proliferation and migration.
Structural, physical and mechanical changes of cement-bonded particleboards during sudden fluctuations in temperature and moisture
Authors: Melichar Tomas , Bydzovsky Jiri , Brozovsky Jiri , Vacula Miroslav 
Published: January 2022

AbstractThe paper presents research focused on behaviour of cement-bonded particleboards with modified composition during sudden changes of temperature and humidity. Four types of boards were made—one control and three modified ones. Finely ground limestone was used as a modifying component in binder. Secondary wood particles made from crushing cuttings of cement-bonded particleboards were used as chips substituent. Two sets of test specimens (1 set = 6 test specimens) were manufactured. The first set was stored in laboratory conditions. The second set was subjected to 10 cycles of sudden changes of temperature (− 20 °C to + 70 °C) and humidity in accordance with EN 321 (further in the paper referred to as “wet–frost–dry cycle”.) After each cycle, dimensions and mass of the test specimens as well as ultrasonic pulse velocity were determined. A detailed analysis of structural changes in boards during cycling was carried out by an optical microscope. After 10 wet–frost–dry cycles were completed, bending strength and modulus of elasticity in bending were determined. The analysis of test results implies a very good relation between change of ultrasonic pulse velocity and width of cracks in the area of interfacial zone between cement matrix and wood particles. This finding also corresponds with dimensional and volumetric changes of the boards. Dependence of bending strength and modulus of elasticity in bending on composition of boards is apparent. Positive influence of secondary spruce chips on dimensional changes of cement-bonded particleboards caused by sudden changes of temperature and humidity was proved. Finely ground limestone contributes to more resistant structure of boards which leads to improved bending properties. Adverse conditions had more considerable influence on bending strength (decrease by 21% to 26%) than on modulus of elasticity in bending (decrease by 12% to 19%).