bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community Insights Regarding COVID-19 Vaccine Uptake Intention versus Hesitancy
Authors: Memon Khalida Naz , Ariser Kanwal Naz , Shah Rafaina , Siddiqui Muhammad Ilyas , Chouhan Shanti , Almas Sindhu 
Published: January 2022

Background: It is widely believed that vaccine hesitancy is prevalent. Achievement of COVID-19 vaccination depends upon public willingness towards immunization against this disease. This study aimed at revealing the underlying situation regarding community hesitancy for COVID-19 vaccine. This study was conducted to determine the level of acceptance of COVID-19 vaccine uptake among community and to seek association between socio-demographic factors and various perceptions about COVID-19 vaccine.
Methods and Materials: A cross-sectional study was carried out on 390 health-care providers and general Pakistani people of age 20 years and above through non probability snowball sampling. An online questionnaire was used to gather data. The socio-demographic variables along with various concepts regarding intentions to take vaccine as well as hesitancy for the same were tried to bring on the surface. The p-value ≤ 0.05 was considered statistically significant.
Results: This study reveals that 61.28% of participants desired to get vaccinated. There was significant association between the desire to get vaccination with participant’s age & occupation (p-value < 0.01). The significant association between the positive views of the health-care providers and the other study subjects (p<0.00) is highly encouraging. The other socio-demographic variables have varied effect on vaccine uptake intentions and hesitancy and require further research on this subject.
Conclusion: The study conducted on three hundred & ninety respondents consistently reveals the significant association between the positive views of the health care providers and the other study subjects with the p-values lesser than 0.001. The study concludes that other socio-demographic fabric of the community showed varied effect on COVID 19 vaccine uptake intentions and hesitancy.
Recommendation: 1. The broad based qualitative research is strongly recommended in order to better seek the community insights & perceptions regarding this public health issue.

The large number of Community people although want to get vaccinated against covid-19, still there is a widespread prevalent doubts about this vaccine as being not so safe for them. Such type of doubts among community necessitate that some counselling sessions be conducted in order to remove uncertainties among common people. Motivations of people need to be raised so as to increase the coverage of covid-19 vaccination.
Microbial Analysis of Contact Lenses
Authors: Tamilmani Hemaanhini , Muralidharan N. P. 
Published: January 2022

Introduction: Contact lenses are small, thin lenses which are worn directly on the surface of the eyes. They can be worn aesthetically or to correct vision. Contact lens related eye infections can lead to serious complications such as blindness, and are associated with several risk factors such as sleeping with lenses, exposure to water, not adhering to replacement schedules, and reusing disinfecting solutions, among others. The severity of the infection may vary with the degree of pathogenicity of the microorganism. Hygiene and handling of contact lenses play a very important role. The main aim of this study is to assess the microbial analysis of contact lenses.
Materials and Methods: A total of 15 lenses were collected in 2 ml sterile saline solution individually and manually agitated for five minutes. The lens was then removed using a sterile toothpick from the container. The sterile container was stored at 4°C till it was processed. 50 microliter of the sample was transferred using a pipette and inoculated on nutrient agar, blood agar and sabouraud dextrose agar. The microorganism (fungus or bacteria) were identified by standard protocol.
Results and Discussion: Bacillus, Staphylococcus aureus and CONS [Coagulase Negative Staphylococci] were found in blood agar. No fungal growth was found among the samples. More importance could be given to contact lenses handling and hygiene to avoid eye related bacterial and fungal infections.
Conclusion: In the present study, the total CFU (Colony Forming Unit) was found to be confluent in all the participants who wore contact lenses for 4 months compared to those who have worn contact lenses from 15 and 28 days. Only bacterial growth was seen in the culture plate. There was no fungal growth seen from the samples collected.
Prevalence of Undernutrition and Its Associated Factors in Tribal Population of Gadchiroli (Vidarbha Region)
Authors: Ambad Ranjit , Jha Roshan Kumar , Bankar Nandkishor , Patil Sachin 
Published: January 2022

Introduction: Under nutrition can be well defined as a result of insufficient food intake, living life with hunger and repeated infection. It comprises being underweight for one’s age, stunted growth where subjects are too short for one’s age, hazardously thin wasted body and deficient in vitamins and minerals also known as micronutrient malnutrition.
Aim: Prevalence Of Under nutrition And Its Associated Factors In Tribal Population Of Gadchiroli at Aheri (Ct), Gadchiroli (Vidarbha Region)District, Maharashtra.
Materials And Methods: Family must consists of 1 children between ages of 1-6 years and their mothers must be available and willing to be interviewed were incorporated in the sample. Unwilling mothers were excluded. Three hundred study participants were included in the study.
Results: The response rate was 100%. Among all participants, 153 (51%) and 147 (49%) were females and males, respectively. Out Of the total parents, 173(57.66%) could not read, 56 (18.66%) can only read and write, 47(15.66%) of them has completed primary education and 24(8%) has completed secondary school. Out of 300 participants, 123 (41%) had monthly income of less than 750 rupeees.
Conclusion: Under nutrition was high among children below six years of age in gadchiroli, Aheri CT, Gadchiroli. Overall under nutrition was high found to be high and proper management should be done.
Systematic Review on Loxapine: A Typical Antipsychotic Drug Used to Treat Agitation in Schizophrenic Patients
Authors: Halim Abdul , Puri Ritika 
Published: January 2022

Loxapine is an antipsychotic drug used in neuroleptic disorders since 1980 with an entrenched drug profile. Drug possesses dibenzoxazepine tricyclic 7-membered heterocyclic ring available commercially as oral, intramuscular and inhalation dosage forms. This review comprises the various study designs of loxapine irrespective of its dose formulations.
A comprehensive and systematic search was conducted on “Scopus”, “Web of science” and “Pub-med” data base and findings were critically analyzed. The data suggests that there is no significant difference in efficacy between typical and atypical antipsychotics. Till now, oral and intramuscular route is widely in use. Oral dosage forms are available in the market for the treatment of agitation related to schizophrenia but it has limitation of delayed onset of action that results in increased risk. Intramuscular formulations reveal a significant difference compared to placebo with respect to agitation but time range could be in range of 15 to 60 minutes. Therefore, there is a need for a novel drug delivery system with rapid action, increased half life, better tolerance by the patient and sustained release to get enhanced patient compliance.
A Comparative Study on Effectiveness of Rocabado Approach and Conventional Physiotherapy on Pain, ROM and QOL in Patients with TMJ Dysfunction
Authors: Pundkar Sushma , Patil Deepali , Naqvi Waqar 
Published: January 2022

Background: Temporomandibular joint disorder or dysfunction (TMD) are considered to be a subclass of the musculoskeletal disorders, so requires physiotherapy treatment. Till now very few studies have been done show the effectiveness of Rocabado approach and conventional physiotherapy, so the research aims to compare the effects of same in patients having mild to moderate Temporomandibular joint disorder.
Methods: Subjects (n = 60) with TMJ dysfunction were selected for a comparative study. The participants were randomized into (1) Group A, and (2) Group B. Participants of Group A received Rocabado approach while Group B received the conventional physiotherapy along with home exercises for a period of 8 days immediately following baseline assessment.
Discussion: The aim of the study was to compare the effectiveness of Rocabado approach and TENS in the patients having mild to moderate Temporomandibular joint disorder. To conclude, we can say that that the current study found evidence to justify the application of Rocabado’s technique to TMJ mobility. It helps patients with TMJ problems having mild to moderate dysfunction to improve their discomfort, mouth opening and quality of life.
A Protocol on Comparative Evaluation of Epidural and Spinal Technique of Labour Analgesia in Rural Women of Central India and their Perceptions Regarding Pain Relief in Labour
Authors: Verma Neeta , Nigam Ankita 
Published: January 2022

Background: Labour pain while giving birth is one of the most excruciatingly painful and emotionally stressful experience for a woman that has piqued the interest of several academicians. Labour pain is induced due to the uterine ischemia, expansion of vagina and birth canal, muscle contractions, and pressure on the bladder. To relieve the severe pain during labour, analgesia is required, which offers pain relief without the loss of consciousness. Regional analgesia (Epidural and spinal) are most commonly used for offering pain relief to women.
Aim: To evaluate whether low dose spinal analgesia is a better alternative to lumbar epidural analgesia for pain relief in labour.
Objectives - Primary objective is to evaluate efficacy of lumbar epidural and spinal analgesia for pain relief in labour. Secondary objective is to evaluate the perceptions of women towards the use of labour analgesia, to evaluate the maternal and fetal outcome and to evaluate the barriers affecting the use of lumbar epidural and spinal analgesia for women during labour.
Methods: In this randomized control trial study, where 60 patients are present in each group. Patients in GROUP E, epidural analgesia will be given using 18-gauge Touhy epidural needle by a loss of resistance to air technique, and after confirmation of space, an epidural catheter will be inserted cranially in L3 - L4 or L4-L5 interspace, and a dose of 15ml of 0.125% bupivacaine with 25µg of fentanyl would be given slowly. Group S patients will receive subarachnoid block using 25-gauge needle inserted and directed to reach the intrathecal space between L3 - L4 or L4 - L5 intervertebral space. After a successful Dural puncture with acceptable CSF flow, 0.1% bupivacaine 2ml with 25µg fentanyl will be given via spinal needle. Throughout the duration of delivery, hemodynamic monitoring including SPO2, ECG, heart rate and blood pressure of mother and fetal heart rate would be monitored under the guidance of obstetrician and anesthesiologists. Patient will be assessed every 5min for the first 15 min, and then every 15 minutes until additional analgesia was requested. The severity of labour pain would be assessed using visual analogue scale. (0 = no pain; 10 = severe pain). Within the first 24 - 48 hours postpartum patient will fill the self-administered questionnaires.
Results: The groups are expected to be similar. However, Low dose spinal analgesia may be a better alternative to lumbar epidural analgesia in providing effective pain relief for women in labour in terms of cost effectiveness. There are no results found as it is just a protocol. Results are yet to come.
Conclusions: The study would offer new insights and knowledge into the use of epidural and spinal analgesia in India, particularly Wardha. The perceptions of women, towards labour analgesia, its consequences or side effects, and the myths associated with its use will be comprehended.
Innovations in the Management System of the Process of Taking Medicines by Patients Based on Digitalization
Authors: Aleksashinа Angelina Aleksandrovna , Bezuglov Sergey Vyacheslavovich , Fomichevа Liliya Mikhailovna , Grigoriev Alexander Vladimirovich , Katlishin Oleg Ilyasovich , Barinov Sergey 
Published: January 2022

In modern conditions, the digitalization of the healthcare sector has increased the pace of development. This is due to the peculiarities of the development of the COVID-19 pandemic and the need to solve issues related to public health more quickly than in the pre-pandemic era.
Today, digital healthcare platforms for diagnosis and monitoring of treatment, patient adherence and tracking of medicinal products are new scientific fields. However, innovative technologies and digital solutions are currently not available to all residents of our country, this is due to the ability to access the Internet, the provision of potential patients with PCs and phones with access to the Global Network. Nevertheless, the introduction of these technologies even in the most remote corners of various countries of the world is necessary, since the constant wave-like development of morbidity indicates a long-term prognosis of the spread of coronavirus infection. Accordingly, people must learn to live and fight this disease, and information technologies in the field of medicine can help them in this. The purpose of the work is to consider innovations in the management system of the process of taking medicines by patients based on digitalization.
Case Report Onventricular Septal Defect (VSD) with Pulmonary Hypertention (Eisenmenger Syndrome) with LSCS
Authors: Thool Bali , Lokhande Shalini 
Published: January 2022

Background: A ventricular septal defect is a defect of the ventricular septal wall where the abnormal opening is present in between the two ventricles. Eisenmenger syndrome is a condition it may develop due to unrepaired heart defect and complication of unrepaired heart defect who is born congenitally. The congenital heart defects lead to Eisenmenger syndrome it developed due to abnormal blood circulate throughout the heart and lungs.
Case Report: The 23-year-old female was admitted to AVBRH with the chief complaints of a history of amenorrhoea since 8 months, complaints of breathlessness during exertion since the 7th month of pregnancy and she was referred to AVBRH from Amravati on date 27/1/2021. At the age of 14 years, she had a history of cyanosis at the time of fever and had recurrent episodes of fever for 2-3 yrs, lasting for 2-3 weeks. She is primigravida and had undergone LSCS on date 3/2/2021. She delivered a male child on date 3/2/2021 of birth weight 1.9kg at 12:15 pm.
Discussion: Patient with pulmonary hypertension and Eisenmenger syndrome where the surgery is contraindicated because in Eisenmenger syndrome surgery is life-threatening. Only medical management is available to treat Eisenmenger syndrome.
Conclusion: Ventricular septal defect in adult females where the pregnancy is contraindicated. Epidural anesthesia should be preferred while the patient undergoes the lower segment cesarean section. This case report concludes that in this condition emergency LSCS is the first choice of treatment and oxygen therapy.
Case Report on Primary Infertility with Hypothyroidism and Diabetes Mellitus
Authors: Bali Thool , Shalini Lokhande , Lalawmpuii A. , Kalyani Ambule , Vaishnavi Shendre , Roshani Warghane 
Published: January 2022

Introduction: Infertility is the inability, by natural means, of an animal to reproduce. Typically, adult species are not in their normal state of health. A woman who is unable to conceive well will define infertility as unable to bear a full-term pregnancy. Because of any ejaculating disease, and any declining sperm count, men are directly liable for 30-40% infertility. The WHO estimates the overall prevalence of primary infertility in India at 3.9% and 16.8%. Fertility estimates differ widely between India and 3.7% in Utter Pradesh and Maharashtra.
Case Presentation: On 9/12/2020, a 38-year-old female came for In Vitro Fertilization with a known case of primary infertility in AVBR Hospital, Wardha. Her complaint was inability to conceive for 4 years, irregular menses, headache, sleep disturbance, loss of appetite. She was admitted for in-vitro fertilization therapy for the 2nd cycle. She had a history of hypothyroidism for 8 years for which she has been taking Thyrox 50mg OD tablet and has Diabetes Mellitus for one year since she is taking Metformin 500mg BD tablet. Instead, she has no concerns about asthma, tuberculosis, epilepsy, etc. On 9/12/2020, she underwent an embryo transfer.
Diagnostic Evaluation: The diagnostic hysteroscopy was conducted at the private hospital in Amravati 2 years ago. She has been diagnosed with nullipara for 4 years as a primary infertility. She has already undergone 2 cycles of Intra Uterine Insemination (IUI) and 1 cycle of in vitro fertilization.
Hysterosalpingography: Both fallopian tubes are normal & patent uterus is normal.
Conclusion: There is multifactorial infertility. In both men and women, anatomy, physiology, the environment, hormones and genetics all play a role in causing infertility. Therefore, in the coming years, it is a very important problem and research in this zone is very essential.
Influence of COVID-19 on Quality of Life among Nurses Treating COVID-19 in Tamil Nadu
Authors: Sadasivam Pooja , S Preetha , Sridevi G. , Prathap Lavanya 
Published: January 2022

Background: COVID-19 is caused by the novel severe acute respiratory syndrome (SARS- COV- 2). The coronavirus is transmitted by different ways, including contact transmission, direct transmission and aerosol transmission. In health care professions the largest and diverse forces are the nurses. Nurses are important in managing the health emergency management crisis because of their vital link between the health care professionals and the patients. The COVID-19 pandemic has placed health care professionals (HCPs) in high stressful circumstances due to increase in patients. Normal life of nurses would be unprecedented disruption and high risk of exposure. The aim of the study is to investigate the quality of life among nurses treating patients during the COVID-19 pandemic.
Materials and Methods: The study setting was an online questionnaire survey among nurses in Tamilnadu. This study was conducted in February 2021. There are 127 participants in this survey. The answers regarding how they feel treating COVID-19 Patients, kind of support, impact and quality of life were collected. The data were analysed statistically using SPSS software. The results and observations were recorded in a pie chart. The chi square test and correlation between genders was done and represented in the bar chart. p<0.05 was statistically significant.
Results: More than 50% of the nurses responded that their quality of life was good. 43.31% Females have a good quality of life. 78% of the nurses replied that they have both physical and mental impact treating COVID-19 Patients. The association between the gender and quality of life of nurses was found with the help of chi square test p=0.383 (p >0.05) and hence it was statistically not significant.
Conclusion: The present study found that the majority of nurses 54.33% have a good quality of life.The officials in the health care system should improve the nurses' working conditions, strategies and their quality of work life, so that nurses will perform their duties properly.
An Evaluation of Hot Water Intake and Relief from Menstrual Cramps among Healthy Females - A Cross Sectional Study
Authors: Rajaselin Annika , Sridevi G. , Preetha S. 
Published: January 2022

Background: Primary dysmenorrhea is menstrual pain that very women undergo during her menstrual phase. It may vary in its frequency and duration in each and every woman. Many home remedies have been followed by females to combat these menstrual cramps. One such treatment is intake of hot water for three days during the menstrual phase
Objective: To aim of the study is to observe the changes experienced by female who consume hot water regularly during menstruation
Methods: The study was conducted in 100 female subjects with regular cycles of menstruation. The participants were administered with a self developed questionnaire consisting of 16 questions relating to the menstrual cramps and the remedies they chose and their regularity of hot water intake and the relief they obtained. The responses were collected using google forms. Descriptive statistics, frequency analysis and chi square test was used to analyze the data.
Results: The study observed that female subjects experienced better results after regular hot water intake during menstruation. It relieves menstrual cramps and improves mental health.
Conclusion: The present study concluded that the majority of the population had a regular habit of taking hot water and experienced improvement and relief from menstrual cramps.
Anticancer Activity of Leaf Hydro Ethanolic Extract of Aegle marmelos in Human Lung Cancer Cell Mediated through Caspase-3 and Caspase-9 mRNA Expression
Authors: Sukanth R. , Sridevi G. , Selvaraj J. , Preetha S. 
Published: January 2022

Background: Aegle marmelos (AE) is a medicinal plant that comes under the rutaceae family and the plant was used in the past for treating many diseases and illness symptoms. The plant has many effects such as anti-diarrhoeal, antimicrobial, antiviral, radioprotective, anticancer, chemopreventive, antipyretic, ulcer healing, antigenotoxic, diuretic, antifertility and anti-inflammatory properties.
Aim: To know the anticancer activity of hydroethanolic leaf extract of Aegle marmelos over lung cancer cells treated with caspase 3 and caspase 9 mRNA expression.
Materials and Methods: The required chemicals were collected mainly from Canada. The lung cancer cells (A549) were collected from NCCS pune and then RNA was extracted from the cells and then the study was conducted after treating it with caspase 3 and caspase 9 mRNA expression. The cells were treated with many dosage of hydroethanolic extract of Aegle marmelos and the cell viability was noted.
Results: The study reported that extract of Aegle marmelos has a great anticancer activity about 1 fold change over rate of 1.7 for cells treated with caspase 3 and a fold change over of 1 in caspase 9 treated lung cancer cells.
Conclusion: The study concluded an innovative finding that the hydroethanolic leaf extract of Aegle marmelos has a great anticancer activity against lung cancer cells treated with caspase 3 and caspase 9 mRNA expression.