bluuebunny/crossref_metadata_2025_split huggingface dataset:
Análisis de las principales implicaciones ambientales por la explotación minera en los sectores del suroriente de Bogotá por mal manejo de los cierres y abandonos al término de la explotación ejecutada
Authors: Pardo Pérez Jenny Judith , Mendoza Márquez José Andrés , Cantor Nelson Antonio , Castro Brayan , Cuevas Daniel 
Published: February 2022

Desde finales de la década de 1990 e inicios de los 2000, Bogotá ha crecido de manera poco planificada en cuanto a infraestructura y construcción. La sabana donde se encuentra ubicada la ciudad es de litología sedimentaria, en pocas palabras, es de gran riqueza en materiales necesarios para el desarrollo de obras civiles y el sector de la construcción. El factor litológico auspicio el inicio de explotaciones mineras en el sur de la ciudad, ubicándose en la cuenca del río Tunjuelo, siendo las de esta zona las de mayor importancia. El desorden y lento desarrollo de la legislación minera y ambiental, la falta de seguimiento a la actividad minera en la ciudad y su territorio, no definir una buena planeación que incluya los usos de los suelos de la ciudad, el auge minero y la ilegalidad, generaron una situación de desarrollo minero en donde alrededor del 90 % de las canteras en explotación en el territorio urbano y rural de la ciudad están en términos de la ilegalidad (El Tiempo, 2016), que afecta visiblemente y de manera directa a la población aledaña, los recursos hídricos y ambientales aledaños a las explotaciones mineras. Debido a esta problemática, en la administración distrital de Gustavo Petro, se decidió prohibir la actividad minera en la ciudad (Secretaría de Ambiente, 2012), que si bien fue un hecho determinante, en sí no fue totalmente la solución, dado que por un mandato del Consejo de Estado, y petición de la Alcaldía Mayor de Bogotá, el Ministerio de Ambiente debe definir la ubicación y gran parte de la situación de esas zonas para hacer frente a las canteras ilegales y las problemáticas socio-ambientales que ha generado la actividad minera. El impacto ambiental causado por la explotación en las canteras ha llevado a la necesidad de analizar esta problemática causada en Bogotá, he aquí porque los estudiantes de Ingeniería de Minas quieren estudiar una alternativa para poder remediar el impacto ambiental producido por el abandono mal realizado al fin de la explotación.
Critical Discourse Analysis Online News of Covid-19 Has Changed The World Of Education (Teun Model A. Van Dijk)
Authors: Mukramah  , Nurhasanah Purba  
Published: February 2022

This aims of the article is to Analysis Critical Discourse Online News of Covid-19 Has Changed the World of Education. This research is a qualitative research using the method of documentation and content analysis of media texts. The result of shows that Critical discourse analysis using the Teun A. Van Dijk method of news taken from online media, namely kompas.com, regarding the Covid-19 statement has changed the world of education. The analysis is carried out on the elements of the text which are divided into macro and micro structures. Based on the analysis that has been done, it is found that discourse fulfills most of the macro and micro elements. All elements are found in this analysis.
La educación y los entornos virtuales de aprendizaje
Authors: Carvajal Morales Jessica Mariela , Carvajal Morales Daira Marizol , Guaña Moya Javier , Mendoza Zambrano Kelvin Antonio 
Published: February 2022

Introducción: La incidencia de las Tecnologías de la Información y la Comunicación (TIC) sobre la sociedad del conocimiento ha originado importantes cambios, especialmente en la forma de transmitirlo y el diseño del contenido, con un gran efecto masivo y multiplicador, de tal manera que el sentido del conocimiento se ha profundizado en todos los niveles sociales, resaltando que el mayor impacto registrado ha recaído sobre los procesos educativos, siendo en las instituciones escolares donde la tecnología ha ejercido la mayor influencia, así como también en la labor del docente, llegando a formar parte de los procesos de enseñanza tradicionales. Objetivo: Analizar el impacto de la incorporación de los entornos virtuales de aprendizaje (EVA) a la educación. Metodología: Por medio de una metodología cualitativa basada en una extensa revisión bibliográfica se analiza el impacto de los EVA sobre la educación, los tipos de herramientas tecnológicas disponibles actualmente, las diversas maneras de aplicación y los aportes que han realizado las TIC sobre los procesos educativos. Resultados: La revisión de literatura permite deducir que la incorporación de las TIC a la educación por medio de los entornos virtuales de aprendizaje (EVA) se ha convertido en un proceso fundamental que en su concepción va más allá de la simple aplicación de herramientas tecnológicas que forman parte del sistema educativo, se refiere a una construcción didáctica y la forma cómo se construye y consolida un aprendizaje significativo basado en la tecnología, por lo que en un sentido estrictamente pedagógico se habla del uso tecnológico a la educación. Conclusiones: Las herramientas tecnológicas como los EVA han incrementado el nivel de significancia y concepción educativa al establecer modelos novedosos de comunicación y generando espacios de formación, información, debate y reflexión, traspasando las barreras de los procesos educativos tradicionales, convirtiéndose en valiosos recursos para el aprendizaje y formación de estudiantes con elevados niveles de competencias personales y profesionales.
AS ÂNCORAS DE CARREIRA DA GERAÇÃO Z
Authors: Chaicoski Monique , Forlin Josiéli Varela , Baade Joel Haroldo 
Published: February 2022

Contextualizar as âncoras de carreiras de jovens da geração Z em formação profissional. O desenvolvimento de carreira é fundamental para qualquer profissional com muitas variáveis, que comandam o comportamento para que se tenha uma compreensão de quais os valores que movem o mundo profissional. Essas âncoras são pilares que orientam as decisões de carreira de cada indivíduo. O teste âncoras de carreira vem com o objetivo fazer com que cada jovem profissional descubra quais delas têm maior peso em sua experiência para o trabalho. O presente estudo vem com a intenção de analisar e comparar as percepções destes 100 jovens respondentes da geração Z sobre carreira e vida profissional. O método de pesquisa utilizado foi o de levantamento de campo. Através de uma pesquisa descritiva quantitativa dos dados. Utilizar-se-á como base de análise o instrumento (inventário de âncoras de carreira) proposto por Schein (1996). Com base nos resultados dos 100 jovens respondentes, as principais âncoras de carreira são: Análise da dimensão competência técnica-funciona (média 3,49); Análise da dimensão segurança e estabilidade (média 3,58); Análise da dimensão senso de dever e dedicação a uma causa (média 3,57); Análise da dimensão desafio puro (média 3,46).
Palavras-Chave: Ancora de carreira. Geração Z. Teste. Formação.

Abstract: Contextualize the anchors of the careers of young generation Z in professional training. Career development is fundamental for any professional with many variables, who command the behavior so that one has an understanding of what values move the professional world. These anchors are the pillars that guide each individual's career decisions. The career anchors test comes with the objective of making each young professional discover which ones have greater weight in their work experience. This study comes with the intention of analyzing and comparing the perceptions of these 100 young generation Z respondents about their career and professional life. The research method used was the field survey. Through a descriptive quantitative research of the data. The instrument (inventory of career anchors) proposed by Schein (1996) will be used as the basis for analysis. Based on the results of the 100 young respondents, the main career anchors are: Analysis of the technical competence-function dimension (average 3.49); Analysis of the security and stability dimension (average 3.58); Analysis of the dimension sense of duty and dedication to a cause (average 3.57); Analysis of the pure challenge dimension (mean 3.46).
Keywords: Career anchor. Generation Z. Test. Training.
Pengaruh Kosentrasi Pupuk Organik Cair Lemna (Lemna minor) yang Berbeda Terhadap Pertumbuhan Mikroalga Chlorella vulgaris
Authors: Indriana Nova , Iba Wa , Idris Muhammad , Ruslaini Ruslaini , Abidin La Ode Baytul , Aslan La Ode Muhammad 
Published: February 2022

Penelitian ini bertujuan untuk mengetahui konsentrasi pupuk organik cair lemna (POC L) yang terbaik sebagai pengganti pupuk komersial media f/2 dalam budidaya mikroalga C. vulgaris. Penelitian ini menggunakan rancangan acak lengkap dengan 5 perlakuan yaitu konsentrasi 5, 10, 15 dan 20 % POC L dan media f/2 sebagai kontrol dengan masing-masing 3 ulangan. Sebanyak 5 x 104 sel/ml C. vulgaris dalam masing-masing 150 ml volume media kultur diamati pertumbuhannya setiap dua hari sekali. Kultur C. vulgaris dipanen setelah mencapai fase stationer pada hari ke-8. Hasil analisis repeated measure ANOVA menunjukkan bahwa perlakuan mempengaruhi pertumbuhan sel (p=0,001). Pertumbuhan sel C. vulgaris yang tertinggi ditemukan pada media f/2 pada hari ke-6 dengan nilai 10,533 x 104 sel/ml. Yield atau kepadatan sel pada fase logarithmik dan fase stationer berbeda untuk semua perlakuan pada hari ke-6 dan ke-8 (p=0,001) dengan kepadatan sel tertinggi ditemukan pada media f/2 dengan nilai berturut-turut adalah 15,6 x 104 dan 15,8 x 104 sel/ml. Kosentrasi POC L 5 % memberikan hasil berat kering dan produktivitas yang sedikit lebih tinggi dengan nilai berturut-turut adalah 3,33 g/l dan 0,580 g/l walaupun secara statistik tidak beberda nyata dengan kosentrasi yang lain. Oleh karena itu hasil penelitian ini menyarankan untuk menggunakan kosentrasi 5 % POC L untuk kultur batch C. vulgaris. Kata kunci: C.vulgaris, POC lemna, pertumbuhan sel dan yield mikroalga
Subtitusi Minyak Ikan Dengan Minyak Jagung Dalam Pakan Terhadap Efisiensi Pakan Dan Pertumbuhan Juvenil Rajungan (Portunus pelagicus) Yang Dipelihara Dalam Sistem Resirkulasi
Authors: Noya Friska Pattricya , Idris Muhammad , Astuti Oce , Kurnia Agus 
Published: February 2022

Penelitian ini bertujuan untuk mengetahui pengaruh subtitusi minyak ikan (MI) dengan minyak jagung (MJ) terhadap pertumbuhan dan kelangsungan hidup benih rajungan (P. pelagicus). Tiga jenis pakan dibuat berdasarkan subtitusi MI dengan MJ yang terdiri atas : Pakan A (6% MI + 0%MJ), Pakan B (3% MI + 3% MJ), dan Pakan C (2% MI + 4% MJ). Sebanyak 36 ekor benih rajungan (bobot awal rata-rata : 39,31±2.20 g) dimasukkan ke dalam 12 akuarium (3 ekor/ akuarium) yang berukuran 60×50×40 cm. Rajungan diberi pakan 2 kali sehari (17.00 dan 22.00 WITA) dengan dosis 10% dari bobot tubuh selama 60 hari pemeliharaan. Hasil Penelitian ini menunjukkan bahwa substitusi MI dengan MJ dalam pakan buatan memberikan pengaruh yang berbeda nyata terhadap konsumsi pakan, rasio konversi pakan, efisiensi pakan, retensi protein, dan retensi lemak.namun tidak memberikan pengaruh yang berbeda nyata terhadap pertumbuhan mutlak rata-rata, laju pertumbuhan spesifik, dan tingkat kelangsungan hidup rajungan. Pertumbuhan mutlak rata-rata yang diperoleh pada penelitian ini berkisar 1,25-2,46 g, laju pertumbuhan spesifik berkisar antara 0,0005-0,00101 %, konsumsi pakan tertinggi diperoleh sebesar 625,68 g, rasio konversi pakan sebesar 187,41, efisiensi pakan 0,85 %, dan tingkat kelangsungan hidup sebesar 75,00-91,67 %. Penelitian ini menyimpulkan bahwa pemberian 3% minyak ikan dan 3% minyak jagung dalam pakan buatan menghasilkan pertumbuhan, efisiensi pakan dan kelangsungan hiduptertinggi juvenil rajungan (P. pelagicus) pada pemeliharaan system resirkulasi Kata Kunci: Juvenil, Rajungan P. pelagicus, Minyak Ikan, Minyak Jagung
Steroidomics of Pregnant Women at Advanced Age
Authors: Yu Bin , Guo Fang , Yang Yuqi , Long Wei , Zhou Jun 
Published: February 2022

ObjectivesTo discover the profiles of different steroid hormones at the maternal-fetal interface and reveal the change characteristics in pregnant women at advanced maternal age (AMA).MethodsForty pregnant women were recruited in the study, including 20 AMA women (age ≥ 35) and 20 normal controls (age &lt; 35 and without pregnancy complications). Among AMA women, 6 (AMA2) had pregnancy complications, and 14 (AMA1) had no complications. Their maternal blood (MB), placental tissue (P), and fetal cord blood (CB) were collected, and 18 different steroid hormone metabolites were analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS).ResultsThe estradiol (E2) levels in MB were higher than those in P and CB. In contrast, the estrone (E1) and estriol (E3) levels were higher in P and CB. Compared with the progesterone levels (P4) in MB, those in P and CB were higher; however, cortisol (F) levels were deficient. In contrast, F in MB was maintained at an elevated level. Further, cortisone (E) levels in CB were higher than those in MB and P. Except for the decline of testosterone (T), androstenedione (A2) and Dihydrotestosterone (DHT), there were no significant differences in the other 15 steroid hormones in MB between the AMA1 and the control group (p&gt;0.05). Compared with the AMA1 group, androgen levels were significantly higher in AMA2, especially in T (1.55 vs. 0.68 ng/ml, p=0.023), A2 (2.27 vs. 0.92 ng/ml, p=0.011) and Dehydroepiandrosterone (DHEA) (2.39 vs. 1.50 ng/ml, p=0.028). However, there were no significant changes in P and CB between two groups.ConclusionThere are distribution rules and cascade changes of steroid profiles in maternal-fetal compartments. Significantly high androgen levels in AMA women have a positive relationship with adverse pregnancy complications.
Adiponectin and Disease Severity in Sickle Cell Anemia Patients Attending a Tertiary Health Institution in Nnewi, Southeast Nigeria
Authors: Okocha Chide Emmanuel , Manafa Patrick O. , Igwe Chioma Nkechinyere , Okite Uchechukwu Prince , Onah Christian Ejike , Efobi Chilota 
Published: February 2022

Background: Hemoglobin polymerization in sickle cell anemia (SCA) leads to abnormally rigid and adhesive erythrocytes that obstruct blood vessels, leading to poor tissue perfusion, hence provoking inflammation and damage of surrounding tissues. Adiponectin, a protein hormone, presumptively has anti-inflammatory characteristics, hence may be an important therapeutic target in SCA.Aim: The aim of the study was to evaluate the status of adiponectin and its correlation with disease severity in SCA.Patients and Methods: A total of 84 subjects were recruited for the study comprising 34 homozygous sickle cell (HbSS) subjects (25 in the steady state and nine in the resolving crisis state) and 50 controls (25 heterozygous sickle cell [HbAS] and 25 hemoglobin phenotype AA subjects). The hemoglobin phenotype, adiponectin levels, and full blood counts were evaluated. Anthropometric measurements were also conducted.Results: A significant difference was observed in the mean body mass index between the different hemoglobin phenotype groups and also between the SCA in crisis resolution patients and the control group (p &lt; 0.05). There was no significant difference in the median serum levels of adiponectin in the different hemoglobin phenotype groups and between SCA patients in the steady state compared with those in the crisis resolution state. Also, there was no correlation between disease severity and adiponectin in SCA patients in the steady state (p = 0.87).Conclusion: Our study seems to suggest that in our data set of sickle cell anemia patients in the steady state, adiponectin does not constitute part of the endocrinopathy that affects these patients.
An Immunoregulatory Role of Interleukin-3 in Allergic Asthma
Authors: Krammer Susanne , Yang Zuqin , Zimmermann Theodor , Xepapadaki Paraskevi , Geppert Carol I. , Papadopoulos Nikolaos G. , Finotto Susetta 
Published: February 2022

BackgroundAllergic asthma is a chronic airway inflammatory disease associated with airway mucus hyper-production. ILC2 cells, which express the Th2 transcription factor GATA3, have been associated with allergic asthma. The cytokine IL-3 is known to support eosinophil, basophil and mucosal mast cell differentiation and survival; however, its role on T regulatory cells as well as on lung ILC2 and in pediatric asthma needs further investigation.ObjectivesTo investigate the role of IL-3 in preschool children and to explore its therapeutic role in experimental asthma.MethodsIn a cohort of preschool children with and without asthma, we analyzed the secretion of IL-3 in nasopharyngeal fluid (NPF) and IL-3 receptor (R) alpha chain mRNA expression in peripheral blood mononuclear cells (PBMCs). In a murine model of allergic asthma, we analyzed the phenotype of wild-type untreated and rIL-3 intranasally treated asthmatic mice.ResultsIL-3 was found downregulated in the nasopharyngeal fluid of children with partially controlled asthma, as compared to control children. Moreover, IL-3 was found induced in phytohemagglutinin (PHA)-stimulated PBMCs from children with asthma and treated with steroids. Finally, IL-3 in NPF directly correlated with the anti-inflammatory molecule sST2 in steroid-treated asthmatic children. Intranasal rIL-3 delivery in vivo during the challenge phase decreased airway mucus production and inflammatory eosinophils. Moreover, rIL-3 given during the challenge phase, reduced lung ST2intGATA3+ILC2, accompanied by an induction of T regulatory cells in the airways.ConclusionsIL-3 was found associated with steroid-resolved asthma. Moreover, treatment with rIL-3 resulted in amelioration of airway eosinophilia and mucus production, two main pathophysiological conditions associated with asthma in a murine model of allergic asthma. Thus, rIL-3 opens new strategies for immunotherapy of this disease.
Health Benefits of Probiotics in Sport and Exercise - Non-existent or a Matter of Heterogeneity? A Systematic Review
Authors: Heimer Melina , Teschler Marc , Schmitz Boris , Mooren Frank C. 
Published: February 2022

BackgroundThe use of probiotics in sports has been growing in recent years, as up to 50% of athletes suffer from training- and performance-limiting gastrointestinal (GI) problems. Moreover, repeated exhaustive exercise and high training loads may lead to a transiently depressed immune function, associated with an increased risk of upper respiratory tract infection (URTI).AimTo provide a qualitative analysis of probiotic effects on URTI, GI symptoms and the immune system in healthy individuals under consideration of performance level as main classifier.MethodsA systematic review of the literature was conducted (PubMed, SPORTDiscus with Full Text, Web of Science) to analyze the effects of probiotics in athletes and healthy active individuals on GI problems, URTI, and the immune system. A qualitative synthesis with performance level and treatment duration as main classifiers was performed.ResultsOf 41 eligible studies, 24 evaluated the effects of probiotic supplements in athletes, 10 in recreationally active individuals and 7 in healthy untrained adults. Large heterogeneity was observed in terms of probiotic strains, mode of delivery, performance level, treatment duration and outcome assessment. Overall, studies provided inconsistent observations.ConclusionThe effects of probiotics on immune system, URTI, and GI symptoms in athletes, healthy adults and recreationally active individuals remain inconclusive. Based on the analyzed studies and identified parameters, this article provides suggestions to align future research on the effects of probiotics in exercise.Systematic Review RegistrationPROSPERO, identifier: CRD42021245840.
Tumor Burden in Patients With Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization: Head-to-Head Comparison of Current Scoring Systems
Authors: Müller Lukas , Hahn Felix , Auer Timo Alexander , Fehrenbach Uli , Gebauer Bernhard , Haubold Johannes , Zensen Sebastian , Kim Moon-Sung , Eisenblätter Michel , Diallo Thierno D. , Bettinger Dominik , Steinle Verena , Chang De-Hua , Zopfs David , Pinto dos Santos Daniel , Kloeckner Roman 
Published: February 2022

ObjectivesRecently, several scoring systems for prognosis prediction based on tumor burden have been promoted for patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE). This multicenter study aimed to perform the first head-to-head comparison of three scoring systems.MethodsWe retrospectively enrolled 849 treatment-naïve patients with HCC undergoing TACE at six tertiary care centers between 2010 and 2020. The tumor burden score (TBS), the Six-and-Twelve score (SAT), and the Seven-Eleven criteria (SEC) were calculated based on the maximum lesion size and the number of tumor nodes. All scores were compared in univariate and multivariate regression analyses, adjusted for established risk factors.ResultsThe median overall survival (OS) times were 33.0, 18.3, and 12.8 months for patients with low, medium, and high TBS, respectively (p&lt;0.001). The median OS times were 30.0, 16.9, and 10.2 months for patients with low, medium, and high SAT, respectively (p&lt;0.001). The median OS times were 27.0, 16.7, and 10.5 for patients with low, medium, and high SEC, respectively (p&lt;0.001). In a multivariate analysis, only the SAT remained an independent prognostic factor. The C-Indexes were 0.54 for the TBS, 0.59 for the SAT, and 0.58 for the SEC.ConclusionIn a direct head-to-head comparison, the SAT was superior to the TBS and SEC in survival stratification and predictive ability. Therefore, the SAT can be considered when estimating the tumor burden. However, all three scores showed only moderate predictive power. Therefore, tumor burden should only be one component among many in treatment decision making.
IgG-like Bispecific Antibody CD3×EpCAM Generated by Split Intein Against Colorectal Cancer
Authors: Wang Lei , Qiao Yu , Zong Huifang , Han Lei , Ke Yong , Pan ZhiDi , Chen Jie , Lu Jun , Li Jinyao , Ying Tianlei , Zhang Baohong , Zhu Jianwei 
Published: February 2022

Background: Colorectal cancer is a commonly diagnosed cancer with high mortality worldwide. Postoperative recidivation and metastasis still are the main challenges in clinical treatments. Thus, it is urgent to develop new therapies against colorectal cancer. Epithelial Cell Adhesion Molecule (EpCAM) is overexpressed in colorectal cancer cells and strongly associated with cancer development. Bispecific antibody (BsAb) is a kind of promising immunotherapy, which could recognize T cells and cancer cells simultaneously to achieve the anti-tumor effects.Methods: A bispecific antibody targeting EpCAM and CD3 with IgG format was genereated by split intein based on the Bispecific Antibody by Protein Splicing” platform. In vitro, the affinity of CD3×EpCAM BsAb was determined by Biolayer interferometry, its cytotoxicity was detected by LDH release assay, T cell recruitment and activation was detected by Flow Cytometry. In vivo, its pharmacokinetic parameters were detected, and anti-tumor effects were evaluated on the tumor cell xenograft mouse model.Results: The results showed that the CD3×EpCAM BsAb could activate and recruit T cells via binding colorectal cells and T cells, which could lead to more potent cytotoxicity to various colorectal cell lines than its parent EpCAM monoclonal antibody (mAb) in vitro. The CD3×EpCAM BsAb had similar pharmacokinetic parameters with EpCAM mAb and inhibits tumor growth on the SW480 tumor cell xenograft mouse model.Conclusion: The CD3×EpCAM BsAb could be a promising candidate for colorectal cancer treatment.