bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential comorbidity profiles in avoidant/restrictive food intake disorder and anorexia nervosa: Does age play a role?
Authors: Kambanis P. Evelyna , Harshman Stephanie G. , Kuhnle Megan C. , Kahn Danielle L. , Dreier Melissa J. , Hauser Kristine , Slattery Meghan , Becker Kendra R. , Breithaupt Lauren , Misra Madhusmita , Micali Nadia , Lawson Elizabeth A. , Eddy Kamryn T. , Thomas Jennifer J. 
Published: July 2022

AbstractObjectiveResearch comparing psychiatric comorbidities between individuals with avoidant/restrictive food intake disorder (ARFID) and anorexia nervosa (AN) is limited. ARFID often develops in childhood, whereas AN typically develops in adolescence or young adulthood. Understanding how age may impact differential psychological comorbidity profiles is important to inform etiological conceptualization, differential diagnosis, and treatment planning. We aimed to compare the lifetime frequency of psychiatric comorbidities and suicidality between females with ARFID (n = 51) and AN (n = 40), investigating the role of age as a covariate.MethodWe used structured interviews to assess the comparative frequency of psychiatric comorbidities/suicidality.ResultsWhen age was omitted from analyses, females with ARFID had a lower frequency of depressive disorders and suicidality compared to AN. Adjusting for age, only suicidality differed between groups.DiscussionThis is the first study to compare comorbidities in a similar number of individuals with ARFID and AN, and a structured clinical interview to confer ARFID and comorbidities, covarying for age, and the first to compare suicidality. Although suicidality is at least three times less common in ARFID than AN, observed differences in other psychiatric comorbidities may reflect ARFID's relatively younger age of presentation compared to AN.Public SignificanceOur results highlight that, with the exception of suicidality, which was three times less common in ARFID than AN irrespective of age, observed differences in psychiatric comorbidities in clinical practice may reflect ARFID's younger age at clinical presentation compared to AN.
Methodological confounds of measuring urinary oxidative stress in wild animals
Authors: Melvin Zoe E. , Dhirani Hussein , Mitchell Christopher , Davenport Tim R. B. , Blount Jonathan D. , Georgiev Alexander V. 
Published: July 2022

AbstractBiomarkers of oxidative stress (OS) are useful in addressing a wide range of research questions, but thus far, they have had limited application to wild mammal populations due to a reliance on blood or tissue sampling. A shift toward non‐invasive measurement of OS would allow field ecologists and conservationists to apply this method more readily. However, the impact of methodological confounds on urinary OS measurement under field conditions has never been explicitly investigated. We combined a cross‐sectional analysis with a field experiment to assess the impact of four potential methodological confounds on OS measurements: (1) time of sampling, (2) environmental contamination from foliage; (3) delay between sample collection and flash‐freezing in liquid nitrogen; and (4) sample storage of up to 15 months below −80°C. We measured DNA oxidative damage (8‐hydroxy‐2′‐deoxyguanosine, 8‐OHdG), lipid peroxidation (malondialdehyde, MDA), total antioxidant capacity (TAC), and uric acid (UA) in 167 urine samples collected from wild Zanzibar red colobus (Piliocolobus kirkii). We found that MDA was higher in samples collected in the morning than in the afternoon but there were no diurnal patterns in any of the other markers. Contamination of samples from foliage and length of time frozen at −80°C for up to 15 months did not affect OS marker concentrations. Freezing delay did not affect OS levels cross‐sectionally, but OS values from individual samples showed only moderate‐to‐good consistency and substantial rank‐order reversals when exposed to different freezing delays. We recommend that diurnal patterns of OS markers and the impact of storage time before and after freezing on OS marker concentrations be considered when designing sampling protocols. However, given the high stability we observed for four OS markers subject to a variety of putative methodological confounds, we suggest that urinary OS markers provide a valuable addition to the toolkit of field ecologists and conservationists within reasonable methodological constraints.
Integrating terrestrial scavenging ecology into contemporary wildlife conservation and management
Authors: Patterson Jessica R. , DeVault Travis L. , Beasley James C. 
Published: July 2022

AbstractScavenging plays a vital role in maintaining ecosystem health and contributing to ecological functions; however, research in this sub‐discipline of ecology is underutilized in developing and implementing wildlife conservation and management strategies. We provide an examination of the literature and recommend priorities for research where improved understanding of scavenging dynamics can facilitate the development and refinement of applied wildlife conservation and management strategies. Due to the application of scavenging research broadly within ecology, scavenging studies should be implemented for informing management decisions. In particular, a more direct link should be established between scavenging dynamics and applied management programs related to informing pharmaceutical delivery and population control through bait uptake for scavenging species, prevention of unintentional poisoning of nontarget scavenging species, the epidemiological role that scavenging species play in disease dynamics, estimating wildlife mortalities, nutrient transfer facilitated by scavenging activity, and conservation of imperiled facultative scavenging species. This commentary is intended to provide information on the paucity of data in scavenging research and present recommendations for further studies that can inform decisions in wildlife conservation and management. Additionally, we provide a framework for decision‐making when determining how to apply scavenging ecology research for management practices and policies. Due to the implications that scavenging species have on ecosystem health, and their overall global decline as a result of anthropic activities, it is imperative to advance studies in the field of scavenging ecology that can inform applied conservation and management programs.
Accumulation and diversity of airborne, eukaryotic environmental DNA
Authors: Klepke Martin Johannesen , Sigsgaard Eva Egelyng , Jensen Mads Reinholdt , Olsen Kent , Thomsen Philip Francis 
Published: July 2022

AbstractEnvironmental DNA (eDNA) metabarcoding is increasingly being implemented as a non‐invasive and efficient approach for biodiversity research and monitoring across ecosystems. However, accurate detection of species with eDNA requires robust experimental designs as eDNA analysis carries a risk of contamination at every step of the fieldwork and laboratory processes. Several studies focus on rigorous laboratory procedures and processing of sequencing data, but surprisingly, little research investigates the process of background input of DNA in the field. For example, airborne DNA from localities outside the study area could potentially contaminate eDNA samples. Here, we use an experimental setup and eDNA metabarcoding to study the diversity and accumulation of airborne eukaryotic eDNA on exposed surfaces in the field. At two different natural locations, a coastal marine site and a terrestrial grassland site, we placed open containers each filled with 0.5 liters of water, which was then sampled at eight successive time points after exposure to the surroundings. We found an accumulation of detected species richness in the samples, which reached its maximum at the end of the experiment, 24 h after exposure. This result was consistent across both sites and across two markers (COI for eukaryotes and 12S for vertebrates). While many of the detected species were contaminants commonly found in eDNA studies, we also detected several other eukaryotic taxa. Most notable were metazoan species such as birds, fish, and insects, likely originating from airborne transport of eDNA. We also found that increasing the number of PCR cycles tended to have a positive impact on richness for the unfiltered reads but a negative impact on the richness after bioinformatic filtering. Our results add to the sparse evidence that metazoan eDNA can be transported by air, which have wide implications for eDNA research and calls for increased implementation of field control samples.
“Going out to get in”—Roles of forest conflicts in bottom‐linked environmental governance progressing toward socio‐political innovations
Authors: Sarkki Simo , Jokinen Mikko , Heikkinen Hannu I. , Nijnik Maria , Melnykovych Mariana , Kluvánková Tatiana 
Published: July 2022

AbstractSocial innovation literature focuses commonly on roles of cooperation in addressing co‐evolution of civil society initiatives and state‐based governance toward sustainable solutions. However, roles of conflicts in driving social change are scarcely addressed in social innovation literature. We elaborated a concept of bottom‐linked environmental governance, which can take place either via collaboration, or by conflict, and which can progress toward socio‐political innovations. We show this progression by examining two longitudinal cases on forest controversies in Northern Finland. These are the cases of Inari and Muonio. They are characterized by dynamic processes of conflicts and collaboration between state‐based organizations (e.g., Finnish forestry enterprise of Metsähallitus), civil society actors (e.g., reindeer herders, nature‐based tourism entrepreneurs and environmental nongovernmental organizations). We conducted a qualitative deductive‐inductive content analysis on the study cases and uncovered a set of “going out to get in” strategies by civil society actors, emerging from frustration on state‐based participatory processes, and consisting of open disputes and pressure strategies outside the participatory processes to gain a seat and power at negotiation tables. Metsähallitus often responded by seeking to maintain its control over forest decisions. The interplay between these strategies led to continuous open disputes and finally to socio‐political innovations (e.g., comanagement arrangement). The findings lead us to discuss reasons for prolonged disputes, the question of whether sociopolitical innovations can benefit all, considerations on power relations, strategies, and counter responses, all being relevant more broadly, for both, social innovation research and decision‐making enabling socio‐political innovations.
Observations of megacusp dynamics and their coupling with crescentic bars at an open, fetch‐limited beach
Authors: de Swart Rinse L. , Ribas Francesca , Calvete Daniel , Simarro Gonzalo , Guillén Jorge 
Published: July 2022

AbstractAlongshore changes in shorelines along sandy beaches are a result of variations in wave conditions and nearshore morphology, which can cause straight shorelines to develop large‐scale (100–1000 m wavelength) undulations, called megacusps, which cause local shoreline accretion and erosion. Megacusps are often morphologically coupled to alongshore variability in the nearshore sandbar (crescentic bars). Sandbar rhythmicity has been studied extensively, whilst megacusp dynamics and their coupling with crescentic bars have received less attention. This study uses a long‐term dataset of hourly time‐exposure video images and detailed propagated wave conditions to investigate megacusp dynamics and the corresponding sandbar–shoreline coupling at the low‐energetic, tideless beach of Castelldefels (northwestern Mediterranean Sea, Spain). Megacusps were observed during 24% of the study period. Crescentic bars were present during 91% of the days with megacusps, whilst megacusps were not observed during 50% of the days with crescentic bars. Megacusp wavelengths (100–700 m) were comparable to those of crescentic bars, whilst cross‐shore amplitudes (3–8 m) and alongshore migration speeds (0–15 m/day) were smaller than those of crescentic bars. No clear relation was observed between wave conditions and megacusp formation, migration and disappearance. However, megacusp presence was strongly linked to crescentic bar presence, as megacusps mostly developed some days after the formation of a crescentic bar. Coupling between shoreline and inner sandbar was significant during 74% of the time with simultaneous presence of megacusps and crescentic bars. No dominance of one particular coupling pattern was observed, although the pattern depended on the wave height and the wave angle. It is hypothesised that the wave height and angle determine the type of flow pattern over the inner crescentic bar (single or double rip cell circulations versus meandering currents) and thus control the type of coupling.
Bioamplification and Biomagnification of Polycyclic Aromatic Hydrocarbons and Halogenated Organic Pollutants in Moths from an Electronic Waste Recycling Site
Authors: Luo Xiao-Jun , Huang Li-Qian , Guan Ke-Lan , Qi Xue-Meng , Zeng Yan-Hong , Mai Bi-Xian 
Published: July 2022

Abstract
Samples of Asota caricae (larvae, pupae, and adults) and its host plant leaf (Ficus hispida), larvae of Aloa lactinea, and mixed adult moths were collected from an electronic waste (e-waste) recycling site in south China. Polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and polybrominated diphenyl ethers were found to exhibit concentrations of 420–1300, 100–860, and 7.6–49 ng/g dry weight, respectively. The different chemical compositions among the samples of the three groups indicated that at least two exposure scenarios occurred among the moths in the study area. A complex relationship between bioamplification factors and the octanol–water partition coefficient (log KOW) was observed during metamorphosis, in which a positive relationship was evident for 5 &lt; log KOW &lt; 7, whereas an inverse relationship occurred for log KOW values outside of this range. The biomagnification factors (BMFs) calculated from the larvae of Asota caricae to the host plant were negatively correlated with log KOW for all chemicals, differing completely from those obtained in previous studies. However, after metamorphosis, the correlation between BMF and log KOW was found to coincide with that in previous studies. These results indicate that the biotransformation of pollutants in organisms played a key role in determining whether or not biomagnification occurred in organisms and highlight the potential application of the metabolic rate of chemicals in screening-level risk assessments of new chemicals. Environ Toxicol Chem 2022;41:2395–2403. © 2022 SETAC
Making the whole greater than the sum of its parts: A literature review of ensemble methods for financial time series forecasting
Authors: Albuquerque Pedro Henrique Melo , Peng Yaohao , Silva João Pedro Fontoura da 
Published: July 2022

AbstractThis paper discusses the application of ensemble techniques for the prediction of time series, presenting an in‐depth review of the main techniques and algorithms used by the recent literature, with emphasis on the bootstrap aggregation (bagging) and boosting approaches. We also discuss the theoretical foundations of the ensemble‐based models, presenting measures of model stability and the main aggregation methods to combine the forecasts of the individual models, as well as recommendations for future developments for related research agendas.
Housing cost burden and material hardship among older adults: How do they influence psychological health?
Authors: Park Gum‐Ryeong , Seo Bo Kyong 
Published: July 2022

AbstractObjectivesDespite a growing body of evidence for the association between housing cost burden and psychological health, few studies have focused on the potential mediators of this association and the extent to which housing cost burden poses a threat to older adults' psychological health. This study aims to assess (a) the link between housing cost burden and psychological health among older adults and (b) how the association is mediated by material hardship.MethodsUsing thirteen waves of a nationally representative longitudinal study in Korea, this study assessed the association between housing cost burden and depressive symptoms among older adults aged 65 or over. Mediation tests were conducted to identify whether material hardship explains the link between housing cost burden and depressive symptoms. We used fixed‐effects models to take into account individual‐level heterogeneity.ResultsHousing cost burden was significantly associated with depressive symptoms among older adults, regardless of their housing tenure status. Different types of material hardship partially mediated the association between housing cost burden and depressive symptoms in older adults. Older adults with severe housing cost burden are more susceptible to all types of material hardship compared to those with a moderate burden.ConclusionsTo contribute further to the social causation discussions, future studies should seek to identify protective factors of depressive symptoms among older adults and other potential mechanisms of the association between older adults' socioeconomic conditions and their psychological health.
Interventions for head and neck cancer survivors: Systematic review
Authors: Margalit Danielle N. , Salz Talya , Venchiarutti Rebecca , Milley Kristi , McNamara Mairead , Chima Sophie , Wong Jamieson , Druce Paige , Nekhlyudov Larissa 
Published: July 2022

AbstractBackgroundInterventions for head/neck cancer (HNC) survivors may not address their cancer‐related and general health needs.MethodsPreferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) guided this systematic review of studies from 2000 to 2021 of interventions targeting cancer survivors treated with curative‐intent, using MEDLINE, Embase, Emcare, and PsycINFO. Interventions were categorized into domains of the Quality of Cancer Survivorship Care Framework to characterize the scope and quality of interventions.ResultsWe identified 28 studies for inclusion: 13 randomized and 15 non‐randomized. Most targeted surveillance/management of physical effects (n = 24) including 13 that also targeted psychosocial effects. Four studies addressed prevention/surveillance for recurrence/new cancers, one addressed health promotion/disease prevention, and one addressed chronic medical conditions. Most studies (n = 27) had medium‐high risk of bias.ConclusionsThere are few high‐quality studies addressing HNC survivorship. Future rigorously designed studies should address broader areas of care, including chronic disease management and health promotion/disease prevention.
NR1H3 (LXRα) is associated with pro‐inflammatory macrophages, predicts survival and suggests potential therapeutic rationales in diffuse large b‐cell lymphoma
Authors: Vegliante Maria Carmela , Mazzara Saveria , Zaccaria Gian Maria , De Summa Simona , Esposito Flavia , Melle Federica , Motta Giovanna , Sapienza Maria Rosaria , Opinto Giuseppina , Volpe Giacomo , Bucci Antonella , Gargano Grazia , Enjuanes Anna , Tabanelli Valentina , Fiori Stefano , Minoia Carla , Clemente Felice , Negri Antonio , Gulino Alessandro , Morello Gaia , Scattone Anna , Zito Alfredo F. , Tommasi Stefania , Agostinelli Claudio , Vitolo Umberto , Chiappella Annalisa , Barbui Anna Maria , Derenzini Enrico , Zinzani Pier Luigi , Casadei Beatrice , Rivas‐Delgado Alfredo , López‐Guillermo Armando , Campo Elias , Moschetta Antonio , Guarini Attilio , Pileri Stefano A. , Ciavarella Sabino 
Published: July 2022

AbstractThe role of macrophages (Mo) and their prognostic impact in diffuse large B‐cell lymphomas (DLBCL) remain controversial. By regulating the lipid metabolism, Liver‐X‐Receptors (LXRs) control Mo polarization/inflammatory response, and their pharmacological modulation is under clinical investigation to treat human cancers, including lymphomas. Herein, we surveyed the role of LXRs in DLBCL for prognostic purposes. Comparing bulk tumors with purified malignant and normal B‐cells, we found an intriguing association of NR1H3, encoding for the LXR‐α isoform, with the tumor microenvironment (TME). CIBERSORTx‐based purification on large DLBCL datasets revealed a high expression of the receptor transcript in M1‐like pro‐inflammatory Mo. By determining an expression cut‐off of NR1H3, we used digital measurement to validate its prognostic capacity on two large independent on‐trial and real‐world cohorts. Independently of classical prognosticators, NR1H3high patients displayed longer survival compared with NR1H3low cases and a high‐resolution Mo GEP dissection suggested a remarkable transcriptional divergence between subgroups. Overall, our findings indicate NR1H3 as a Mo‐related biomarker identifying patients at higher risk and prompt future preclinical studies investigating its mouldability for therapeutic purposes.
Circulating plasma phospholipid fatty acid levels and breast cancer risk in the Cancer Prevention Study‐II Nutrition Cohort
Authors: Matta Michèle , Deubler Emily , Chajes Veronique , Vozar Beatrice , Gunter Marc J. , Murphy Neil , Gaudet Mia M. 
Published: July 2022

AbstractProspective studies that objectively measure circulating levels of fatty acids are needed to clarify their role in the etiology of breast cancer. Thirty‐eight phospholipid fatty acids were measured using gas chromatograph in the plasma fraction of blood samples collected prospectively from 2718 postmenopausal women (905 breast cancer cases) enrolled in the Cancer Prevention Study II Nutrition Cohort. Associations of 28 fatty acids that passed quality control metrics (modeled as per 1‐SD increase) with breast cancer risk were assessed using multiple variable conditional logistic regression models to compute odds ratios (OR) and 95% confidence intervals (CI). The false discovery rate (q value) was computed to account for multiple comparisons. Myristic acid levels were positively associated with breast cancer risk (OR, 1.17, 95% CI: 1.07‐1.28; q value = 0.03). Borderline associations were also found for palmitoleic acid (OR, 1.14, 95% CI: 1.04‐1.24) and desaturation index16 (OR, 1.10, 95% CI: 1.01‐1.20) at nominal P values (<.03) (q values>0.05). These findings suggest that higher circulating levels of myristic acid, sourced from dietary intake of palm kernel oils along with increased de novo synthesis of fatty acids, may increase breast cancer risk. Additional studies are needed to investigate de novo synthesis of fatty acid in breast cancer tissues.
China's global value chain linkage and logistics performances in emerging ASEAN economies
Authors: Taguchi Hiroyuki , Zhao Jun 
Published: July 2022

AbstractThis paper aims to evaluate the extent of China's forward linkage of global value chains (GVCs) with emerging market economies of the Association of Southeast Asian Nations (ASEAN) compared to those with the United States and Japan, and also to examine the nexus of China's forward GVC linkage with logistics performances in emerging ASEAN economies as China's trade partners. This study uses the UNCTAD‐Eora Database and applies a structural gravity trade model for empirical analysis. The statistical observations identified the major position of China's GVC, which has transformed from a backward linkage to a forward linkage since the mid‐2000s. The empirical estimation verified that there is less linkage in China's forward GVC with emerging ASEAN economies than with the United States and Japan, and demonstrated that the lack of logistics performances in emerging ASEAN economies has been a significant factor in explaining the less linkage in China's forward GVC with them.