bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors and outcomes of patient safety culture: a cross-sectional comparative study
Authors: Mrayyan Majd T 
Published: July 2022

BackgroundDeveloping a safety culture in hospitals improves patient safety-related initiatives. Limited recent knowledge about patient safety culture (PSC) exists in the healthcare context.AimsThis study assessed nurses’ reporting on the predictors and outcomes of PSC and the differences between the patient safety grades and the number of events reported across the components of PSC.MethodsA cross-sectional comparative research design was conducted. The Strengthening the Reporting of Observational Studies in Epidemiology (https://www.strobe-statement.org/index.php?id=available-checklists) guided the study. The researcher recruited a convenience sample of 300 registered nurses using the hospital survey on patient safety culture, with a response rate of 75%.ResultsNurses reported PSC to be ‘moderate’. Areas of strength in PSC were non-punitive responses to errors and teamwork within units. Areas that needed improvements were the supervisor’s/manager’s expectations and actions in promoting safety and communication openness. Some significant correlations were reported among PSC components. Significant differences in means were observed for patient safety grades in six out of the ten PSC components and one outcome item. Organisational learning/continuous improvement, hospital handoffs and transitions, years of experience in the current hospital, the supervisor’s/manager’s expectations and actions in promoting safety and gender predicted PSC. Of the outcomes, around half of the sample reported a ‘very good’ patient safety grade, and ‘no events’ or ‘one to two events’ only were reported, and nurses ‘agreed’ on the majority of items, which indicates a positive perception about the overall PSC in the hospitals. In addition, nurses ‘most of the time’ reported the events when they occurred. PSC components correlated significantly and moderately with PSC outcomes.Conclusion and relevance to clinical practicePSC was moderate with an overall positive nurses’ perceptions. PSC’s strengths should be maintained, and areas of improvement should be prioritised and immediately tackled. Assessing PSC is the first step in improving hospitals’ overall performance and quality of services, and improving patient safety practices is essential to improving PSC and clinical outcomes.
Lipid-loaded macrophages as new therapeutic target in cancer
Authors: Marelli Giulia , Morina Nicolò , Portale Federica , Pandini Marta , Iovino Marta , Di Conza Giusy , Ho Ping-Chih , Di Mitri Diletta 
Published: July 2022

AbstractMacrophages are main players of the innate immune system. They show great heterogeneity and play diverse functions that include support to development, sustenance of tissue homeostasis and defense against infections. Dysfunctional macrophages have been described in multiple pathologies including cancer. Indeed tumor-associated macrophages (TAMs) are abundant in most tumors and sustain cancer growth, promote invasion and mediate immune evasion. Importantly, lipid metabolism influences macrophage activation and lipid accumulation confers pathogenic features on macrophages. Notably, a subset of lipid-loaded macrophages has been recently identified in many tumor types. Lipid-loaded TAMs support tumor growth and progression and exert immune-suppressive activities. In this review, we describe the role of lipid metabolism in macrophage activation in physiology and pathology and we discuss the impact of lipid accumulation in macrophages in the context of cancer.
Impact of apremilast on quality of life in Behçet’s syndrome: analysis of the phase 3 RELIEF study
Authors: Hatemi Gülen , Mahr Alfred , Takeno Mitsuhiro , Kim Doyoung , Melikoğlu Melike , Cheng Sue , McCue Shannon , Paris Maria , Chen Mindy , Yazici Yusuf 
Published: July 2022

ObjectiveTo assess apremilast’s impact on patient quality of life (QoL) in active Behçet’s syndrome and correlations between improvement in patients’ QoL and efficacy measures in the phase 3 RELIEF study.MethodsQoL measures included Behçet’s Disease QoL (BDQoL), 36-Item Short-Form Health Survey V.2 (SF-36v2) Physical/Mental Component Summary (PCS/MCS) and eight subscale scores, focusing on Physical Functioning (PF). Pearson’s correlation coefficients assessed relationships between efficacy endpoints (oral ulcer count, oral ulcer pain, Behçet’s Syndrome Activity Scale (BSAS), Behçet’s Disease Current Activity Form (BDCAF)) and QoL endpoints for apremilast at Week 12.ResultsApremilast (n=104) demonstrated significantly greater improvements versus placebo (n=103) in SF-36v2 PCS (3.1 vs 0.9), MCS (4.6 vs ─0.7) and PF (2.9 vs 0.14), respectively (all p<0.05). Mild correlations were observed in improvements of SF-36v2 measures (PCS, MCS, PF) with oral ulcer count (r=−0.11, PCS), and change in oral ulcer pain from baseline (r=−0.28, PCS; r=−0.10, PF) and BSAS (r=−0.38, PCS; r=−0.20, PF; r=−0.16, MCS). Correlations among BDCAF and SF-36v2 components and BDQoL were variable. BDQoL showed mild/moderate correlations with SF-36v2 components (r=−0.18, PCS; r=−0.13, PF; r=−0.45, MCS).ConclusionsApremilast was associated with significant improvements in QoL measures of SF-36v2 PCS, MCS and PF and BDQoL in patients with Behçet’s syndrome. Correlations of improvement among QoL endpoints support the beneficial clinical effects of apremilast in Behçet’s syndrome.Trial registration numberNCT02307513.
Procedures for the content, conduct and format of EULAR/PReS paediatric musculoskeletal ultrasound courses
Authors: Magni-Manzoni Silvia , Muratore Valentina , Vojinović Jelena , Pires Marafon Denise , D'Agostino Maria Antonietta , Naredo Esperanza 
Published: July 2022

BackgroundDespite the worldwide increasing request of education on paediatric musculoskeletal ultrasound (PedMSUS), content, conduct and format of PedMSUS courses have never been internationally agreed.ObjectivesTo produce educational procedures for the conduct, content and format of EULAR/PReS PedMSUS courses.MethodsAfter a systemic literature review and expert opinion collection, a panel of items for the development of procedures on PedMSUS courses was identified. Agreement on the items was assessed through Delphi surveys among a taskforce of 24 members, which included 18 experts in PedMSUS (8 rheumatologists, 1 radiologist, 9 paediatric rheumatologists), 1 methodologist and rheumatologist expert in MSUS, 2 patient research partners, 1 health professional in rheumatology and 2 EMEUNET/EMERGE members, from 8 different European countries. Each item was assessed through a 5-point Likert scale (0, full disagreement; 5, full agreement); agreement was reached for >75% of answers rating 4–5. All items with agreement were included in the preliminary core set of educational procedures, which underwent external assessment by a broader Consensus group (Faculty and Tutors of previous EULAR PedMSUS courses and PReS Imaging Working Party members), through Delphi survey.ResultsTwo Delphi surveys produced the preliminary core set of procedures for basic, intermediate, advanced and teach-the-teachers (TTT) PedMSUS courses. A Delphi survey within the Consensus group produced agreement on the proposed procedures.ConclusionsShared EULAR/PReS procedures for the conduct, content and format of basic, intermediate, advanced and TTT PedMSUS courses were identified on international basis.
Evaluating the construct validity of text embeddings with application to survey questions
Authors: Fang Qixiang , Nguyen Dong , Oberski Daniel L. 
Published: July 2022

AbstractText embedding models from Natural Language Processing can map text data (e.g. words, sentences, documents) to meaningful numerical representations (a.k.a. text embeddings). While such models are increasingly applied in social science research, one important issue is often not addressed: the extent to which these embeddings are high-quality representations of the information needed to be encoded. We view this quality evaluation problem from a measurement validity perspective, and propose the use of the classic construct validity framework to evaluate the quality of text embeddings. First, we describe how this framework can be adapted to the opaque and high-dimensional nature of text embeddings. Second, we apply our adapted framework to an example where we compare the validity of survey question representation across text embedding models.
Herpes Virus Pseudotumor in a Patient with HIV Immunosuppression
Authors: York Daniel , Patel Pavan , Saikumar Smera 
Published: July 2022

Background. In rare cases, HSV infections can present as pseudotumors that are often mistaken as malignancies in patients with an uncontrolled HIV infection. Herpes simplex virus type 2 (HSV-2) infection rates range from 60% to 90% in individuals coinfected with HIV. Case Presentation. A 48-year-old patient presented with a large fungating mass near her right inferior vulva with a hardness of surrounding tissues. The mass was

4

cm
×
3

cm

in size and was excised in the operating room. The pathology was negative for malignancy; however, it showed lymphoplasmacytic proliferation with immunostaining positive for HSV virus. Conclusion. Atypical HSV pseudotumors should be considered in the differential diagnosis for an immunosuppressed patient who presents with a genital mass lesion.
Description and Dynamic Analyses of the 1935 Luchedu Rock Avalanche in Sichuan, China
Authors: Cui Jie , Gao Chunyu , Zhang Zhilong , Xiang Guifu 
Published: July 2022

The Luchedu rock avalanche (LRA) that occurred in 1935 at the junction of Sichuan and Yunnan in Southwest China is a disaster chain of the rock slide, debris avalanche, and river blocking induced by heavy rainfall. The rock slide originated from the wedge formed by sheet metamorphic rocks on the fault zone on the left bank of the Jinsha River. After breaking away from the slope, the wedge disintegrated and cracked rapidly, forming debris and causing them to flow in fluidization along a 7.3 km path. After the obvious entrainment process and curve superelevation in the proximal area, the deposition reached

50.5
×

10

6

m3 in the distal area. The sedimentary structure of clasts has typical stratification characteristics. The types of sedimentary facies include carapace facies, body facies, and mixed facies. Inside the sedimentary structure, dense shear zones, liquefied intercalations, jigsaw structures, and directional arrangement of particles are observed. Through a detailed geological survey and DEM spatial analysis, the avalanche entrainment rate of LRA was determined as 1.2. The morphological fluctuation of basement lithology and gully path plays an important role in the long-distance movement. The rock fragments formed by metamorphic rocks with a primary schistosity structure can effectively reduce the energy loss in the internal shear process and significantly promote the laminar flow movement in the distal region of the avalanche. Therefore, as a giant rock avalanche formed by the evolution of specific metamorphic rocks, LRA results from the combination of macrohydrodynamics and microrock failure properties.
Profil Klinikopatologi Pasien Osteosarcoma di Instalasi Patologi Anatomi RSUD Dr. Saiful Anwar Malang Periode 2018–2020
Authors: Prihantoro Teguh , Dewi Rose , Norahmawati Eviana 
Published: July 2022

Pendahuluan: Osteosarcoma merupakan keganasan tulang primer tersering dan memiliki prognosis yang kurang baik. Meskipun tumor primer telah dilakukan pembedahan, pasien tetap berisiko tinggi mengalami metastasis. Sehingga angka kejadian dan karakteristik klinikopatologis osteosarcoma perlu diteliti.
Tujuan: Mendapatkan data epidemiologi untuk membantu manajemen diagnosis dan tatalaksana pasien osteosarcoma.
Metode: Penelitian ini dilakukan secara deskriptif retrospektif. Data didapat dari rekam medik laboratorium patologi anatomi RSU Dr. Saiful Anwar Malang tahun 2018-2020 yang memenuhi kriteria inklusi dan kriteria eksklusi. Variabel yang diteliti meliputi jenis kelamin, usia, lokasi, subtipe, grade, penilaian Huvos grading.
Hasil: Didapatkan 68 kasus osteosarcoma yang memenuhi kriteria. Sebanyak 23 kasus di tahun 2018, 23 kasus di tahun 2019, dan 22 kasus di tahun 2020. Didapatkan dari pemeriksaan FNA sebanyak 43, HPA sebanyak 23, dan dari IHK 2 kasus. Penderita terbanyak laki-laki (52.94%). Usia penderita mulai 8 tahun hingga 79 tahun. Dengan rata-rata usia 24,56 tahun, median usia 16 tahun, dan terbanyak pada rentang usia 11-20 tahun. Lokasi tersering pada ekstremitas inferior (82.35%). Subtipe terbanyak adalah osteosarcoma NOS (94.12%). Grade terbanyak merupakan High grade (94.12%). Dari keseluruhan kasus osteosarcoma, didapatkan 3 kasus yang dilakukan huvos grading, didapatkan 1 kasus merupakan grade 1, dan sebanyak 2 kasus merupakan grade 2.
Kesimpulan: Penderita osteosarcoma terbanyak laki-laki, tersering pada rentang usia 11-20 tahun. Lokasi tersering pada ekstremitas inferior, subtipe terbanyak osteosarcoma NOS, grade terbanyak high grade. Sebagian besar kasus tidak dilakukan dilakukan huvos grading.
Sebuah Kasus Lucio Phenomenon yang Fatal pada Pasien Lucio’s Leprosy
Authors: Puspitasari Galuh , Yuniaswan Anggun , Ekasari Dhany 
Published: July 2022

Penegakan diagnosis Lucio’s leprosy sulit karena manifestasi pada kulit yang tidak khas, sehingga pasien sering datang ketika kondisi sudah berat disertai Lucio phenomenon. Seorang laki-laki berusia 33 tahun, mengeluhkan bercak biru keunguan dan luka disertai lepuhan yang tersebar di seluruh tubuh sejak 4 hari terakhir. Terdapat kerontokan alis dan bulu mata sejak 1 tahun terakhir, namun tidak didapatkan riwayat keluh(1)(1)an bercak kulit mati rasa maupun gangguan saraf. Pemeriksaan dermatologis didapatkan patch plak purpura stelata, multipel, bentuk dan ukuran bervariasi, tersebar hampir di seluruh tubuh. Pada semua regio ekstremitas ditemukan bula disertai erosi, sebagian tertutup jaringan nekrotik berwarna kehitaman dengan BSA mencapai 40%. Pemeriksaan slit skin smear ditemukan bakteri tahan asam dengan index bakteri +6 dan index morfologi 1 %. Pemeriksaan histopatologi menunjukkan reaksi radang granulomatosa terdiri dari sel epitheloid, histiosit, sel foam, disertai gambaran vaskulitis. Sedangkan pada pewarnaan Ziehl Neelsen ditemukan bakteri tahan asam dalam jumlah yang banyak, tersebar di area dermis, dan sebagian mencapai endotel pembuluh darah mendukung gambaran Lucio phenomenon. Pasien juga mengalami anemia berat, neutrofilia, hiperkalemia, hipoalbuminemia berat. Luasnya lesi serta kondisi sepsis mempersulit penatalaksanaan penyakit ini dan memperburuk kondisi pasien sehingga meningkatkan morbiditas dan mortalitas. Lucio phenomenon merupakan reaksi kusta berat yang sulit dikenali dengan manifestasi klinis berupa lesi kutaneus necrotizing erythema, terutama pada ekstremitas. Keterlibatan lesi yang luas serta sepsis merupakan kendala utama yang sering ditemui selama tatalaksana kasus, seperti juga pada kasus ini. Pemberian Multidrug therapy untuk kusta multibasiler (MDT-MB) sesuai regimen WHO merupakan terapi utama yang dapat dikombinasikan dengan kortikostreoid sistemik.
The Philosophy of History and New Testament History: A Survey of the Former with Some Implications for the Latter
Authors: Nadeau Nathan J. 
Published: July 2022

Abstract
This article surveys a selection of figures in the recent history of historiography with particular focus on their discussion of the nature of historical epistemology (including facts, evidence, and knowledge) and concludes with implications for New Testament history. Figures and works are selected for their representativeness of new thinking in the field at their time, their critique of prior thinking, and in some cases their reception/critique by representatives of that prior thinking. Specifically, I consider in varying depth the historical epistemology of E. H. Carr, G. R. Elton, Hayden White, Richard Evans, Frank Ankersmit, John Zammito, and Aviezer Tucker. These exemplars are considered in order to construct a landscape of traditional, postmodern, and post-postmodern philosophy of historical epistemology. The survey is selective, but the effect is dialectic; ending with recent post-positivist historical epistemology, I raise a number of considerations for thinking about New Testament history.
Technology Transfer and Everyday Life among Smallholder Farmers: Notes on the Small Inconveniences that Slow the Transition to Industrial Agriculture in Ethiopia
Authors: Negatu Selam Esayas , Holzer Elizabeth , Atsbeha Ezana Amdework , Kirksey Kristen 
Published: July 2022

Abstract
Global technology transfers reshape agriculture with profound influences on everyday life. Substantial research has documented broader constraints that influence technology transfer among farmers, yet existing theories give us a narrow view into how wider dynamics manifest in everyday life. Using tractor farming in Ethiopia as a case study with ethnographic and historical data, we contribute an account of the everyday social and ecological interactions that shape agricultural technology transfer as well as the wider historical context in which these practices play out. Historically, we find an uneven transition that faltered repeatedly over 50 years. Ethnographically, we identify three types of interplays between actors and the local ecology that shaped the ways that faltering technology transfer actually plays out on the ground: (1) socio-ecological frictions; (2) communicative frictions; and (3) status-based frictions. This study contributes a humanistic account of how farmers and local technology providers experience technology transfers.
Legal Origins, Governance and Bank Lending
Authors: Gani Azmat , Al-Abri Almukhtar , Al Kharusi Sami Salim , Al Foori Alya 
Published: July 2022

Abstract
This article investigates if legal origins and governance impact lending by banks in a large sample of low- and middle-income countries for 2004 to 2017. The results revealed that countries with British legal origin, the strength of the legal systems, the rule of law, and regulatory quality are positively and statistically significantly correlated with the credit provided by the banks, among other factors. The estimations based on data for the post-global financial crisis revealed that in countries with British legal origin, the rule of law and regulatory quality mattered intensely in the banking sector’s credit. The results imply that the developing countries should continue to sustain and improve their good governance practices and improve on contract enforcements to allow maximum leverage practices of good governance that can positively influence credit diffusion by the banks.
Antoine Faivre (1934–2021)
Authors: Hanegraaff Wouter J. , Brach Jean-Pierre , Pasi Marco 
Published: July 2022

Abstract
This article provides a biographical overview and analysis of the life and career of Antoine Faivre (1934–2021), the French scholar who first conceptualized esotericism as an academic field of study and also stood at the cradle of the journal Aries. After his early years as a scholar of literature, Faivre’s mature career can be divided into four main periods: (1) from 1961 to 1969, he established his reputation as a leading historian of eighteenth-century Christian Theosophy and Illuminism; (2) then from 1969 to 1979, the year in which he was appointed to the first academic chair for ‘Western esotericism’ at the École Pratique des Hautes Études in Paris, he embarked on a parallel career of religionist activism marked by a strong Christian-spiritual engagement; (3) from 1979 to 1992, his experiences as a visiting professor at the University of Berkeley and in various other international contexts led to a broadening of his scholarly vision and a gradual retreat from religionism back to more standard historical perspectives; (4) from 1992 to his retirement in 2002, his prodigious scholarly output in several languages established his lasting international reputation as the foundational scholar of ‘Western esotericism’. Faivre remained active as a scholar until just a few years before his death. This article explores the complex interaction, in his personal development, between a strictly academic ‘outsider’ perspective and a simultaneous ‘insider’ involvement in several contemporary esoteric traditions, from Sophianic Theosophy and (neo)Martinism to the Christian-Masonic Rite Écossais Rectifié.
Comparative genetic research on Microtus mystacinus (de Filippi, 1865) distributed in Asia and Europe inferred from mitochondrial (CYTB and COXI) and nuclear (IRBP) gene regions
Authors: Çetintürk Derya , Yiğit Nuri , Castiglia Riccardo , Senczuk Gabriele , Çolak Ercüment 
Published: July 2022

Abstract
The East European vole Microtus mystacinus is the most widespread vole species in Anatolia. It is also frequently seen in watery habitats in a large area of Eurasia. In this paper, an attempt was made to ascertain the level of genetic differentiation between Anatolian (Asian part of Turkey) and Turkish Thracian (European part of Turkey) populations together with additional data from other parts of Asia and Europe by analysing two mitochondrial (cytochrome-b and cytochrome oxidase subunit I) and one nuclear (interphotoreceptor retinoid binding protein) gene regions. Acquired Bayesian Inference trees mostly separated the Asian and European populations of M. mystacinus and the fixation index values implied a significant differentiation between these populations for mitochondrial DNA. On the other hand, the median-joining networks did not show diverging populations, significantly, and the mean genetic distance values among populations were found to be low for both mitochondrial and nuclear DNA. Evolutionary divergence times of Asian and European populations were also calculated and dated back to approximately 0.316–0.111 million years ago, coinciding with the ice ages of the Pleistocene epoch. According to the obtained results, M. mystacinus populations have not diverged enough to form different species; however, there is a separation between Asian and European populations which might result in speciation.
A Lawyer in Exile: Johannes M. de Moor and the Circulation of Legal Knowledge in Wartime London
Authors: Weydner Sara 
Published: July 2022

Abstract
De Moor’s biography illustrates how people and ideas travelled between and within national and transnational spaces. He played a role in the circulation of legal knowledge in the transnational epistemic community, more precisely between the Cambridge Commission and the London International Assembly. In thinking about the future of the international order and the place of nation states within it, De Moor came to embrace the idea that state sovereignty and the rule of law had to be recalibrated and that, as a logical conclusion, war crimes could be prosecuted internationally. In London, he became an advocate for a universal organization backed by an international court and an international armed force. He envisioned an international rule of law as the underlying system governing the international order.