bluuebunny/crossref_metadata_2025_split huggingface dataset:
FDA Approval Summary: Pemigatinib for Previously Treated, Unresectable Locally Advanced or Metastatic Cholangiocarcinoma with FGFR2 Fusion or Other Rearrangement
Authors: Patel Timil H. , Marcus Leigh , Horiba M. Naomi , Donoghue Martha , Chatterjee Somak , Mishra-Kalyani Pallavi S. , Schuck Robert N. , Li Yangbing , Zhang Xinyuan , Fourie Zirkelbach Jeanne , Charlab Rosane , Liu Jiang , Yang Yuching , Lemery Steven J. , Pazdur Richard , Theoret Marc R. , Fashoyin-Aje Lola A. 
Published: October 2022

AbstractOn April 17, 2020, the FDA granted accelerated approval to pemigatinib (PEMAZYRE, Incyte Corporation) for the treatment of adults with previously treated, unresectable locally advanced or metastatic cholangiocarcinoma with an FGFR2 fusion or other rearrangement as detected by an FDA-approved test. Approval was based on FIGHT-202 (NCT02924376), a multicenter open-label single-arm trial. Efficacy was based on 107 patients with locally advanced unresectable or metastatic cholangiocarcinoma whose disease had progressed on or after at least one prior therapy and had an FGFR2 gene fusion or rearrangement. Patients received pemigatinib, 13.5 mg orally, once daily for 14 consecutive days, followed by 7 days off therapy. Safety was based on a total of 466 patients, 146 of whom had cholangiocarcinoma and received the recommended dose. Efficacy endpoints were overall response rate (ORR) and duration of response (DOR) determined by an independent review committee using RECIST 1.1. ORR was 36% (95% confidence interval: 27–45). Median DOR was 9.1 months. The most common adverse reactions were hyperphosphatemia, alopecia, diarrhea, nail toxicity, fatigue, dysgeusia, nausea, constipation, stomatitis, dry eye, dry mouth, decreased appetite, vomiting, arthralgia, abdominal pain, hypophosphatemia, back pain, and dry skin. Ocular toxicity and hyperphosphatemia are important risks of pemigatinib. The recommended dosage is 13.5 mg orally once daily for 14 consecutive days followed by 7 days off therapy in 21-day cycles. FDA also approved the FoundationOne CDX (Foundation Medicine, Inc.) as a companion diagnostic for patient selection.
Investigation of Copy Number Variation in South African Patients With Congenital Heart Defects
Authors: Saacks Nicole A. , Eales James , Spracklen Timothy F. , Aldersley Thomas , Human Paul , Verryn Mark , Lawrenson John , Cupido Blanche , Comitis George , De Decker Rik , Fourie Barend , Swanson Lenise , Joachim Alexia , Brooks Andre , Ramesar Raj , Shaboodien Gasnat , Keavney Bernard D. , Zühlke Liesl J. 
Published: October 2022

Background:
Congenital heart disease (CHD) is a leading non-infectious cause of pediatric morbidity and mortality worldwide. Although the etiology of CHD is poorly understood, genetic factors including copy number variants (CNVs) contribute to the risk of CHD in individuals of European ancestry. The presence of rare CNVs in African CHD populations is unknown. This study aimed to identify pathogenic and likely pathogenic CNVs in South African patients with CHD.

Methods:
Genotyping was performed on 90 patients with nonsyndromic CHD using the Affymetrix CytoScan HD platform. These data were used to identify large, rare CNVs in known CHD-associated genes and candidate genes.

Results:

We identified eight CNVs overlapping known CHD-associated genes (
GATA4
,
CRKL
,
TBX1
,
FLT4
,
B3GAT3
,
NSD1
) in six patients. The analysis also revealed CNVs encompassing five candidate genes likely to play a role in the development of CHD (
DGCR8
,
KDM2A
,
JARID2
,
FSTL1
,
CYFIP1
) in five patients. One patient was found to have 47, XXY karyotype. We report a total discovery yield of 6.7%, with 5.6% of the cohort carrying pathogenic or likely pathogenic CNVs expected to cause the observed phenotypes.

Conclusions:
In this study, we show that chromosomal microarray is an effective technique for identifying CNVs in African patients diagnosed with CHD and have demonstrated results similar to previous CHD genetic studies in Europeans. Novel potential CHD genes were also identified, indicating the value of genetic studies of CHD in ancestrally diverse populations.
Sox17
Deficiency Promotes Pulmonary Arterial Hypertension via HGF/c-Met Signaling
Authors: Park Chan Soon , Kim Soo Hyun , Yang Hae Young , Kim Ju-Hee , Schermuly Ralph Theo , Cho Ye Seul , Kang Hyejeong , Park Jae-Hyeong , Lee Eunhyeong , Park HyeonJin , Yang Jee Myung , Noh Tae Wook , Lee Seung-Pyo , Bae Sun Sik , Han Jinju , Ju Young Seok , Park Jun-Bean , Kim Injune 
Published: October 2022

Background:

In large-scale genomic studies,
Sox17
, an endothelial-specific transcription factor, has been suggested as a putative causal gene of pulmonary arterial hypertension (PAH); however, its role and molecular mechanisms remain to be elucidated. We investigated the functional impacts and acting mechanisms of impaired Sox17 (SRY-related HMG-box17) pathway in PAH and explored its potential as a therapeutic target.

Methods:

In adult mice,
Sox17
deletion in pulmonary endothelial cells (ECs) induced PAH under hypoxia with high penetrance and severity, but not under normoxia.

Results:

Key features of PAH, such as hypermuscularization, EC hyperplasia, and inflammation in lung arterioles, right ventricular hypertrophy, and elevated pulmonary arterial pressure, persisted even after long rest in normoxia. Mechanistically, transcriptomic profiling predicted that the combination of
Sox17
deficiency and hypoxia activated c-Met signaling in lung ECs. HGF (hepatocyte grow factor), a ligand of c-Met, was upregulated in
Sox17
-deficient lung ECs. Pharmacologic inhibition of HGF/c-Met signaling attenuated and reversed the features of PAH in both preventive and therapeutic settings. Similar to findings in animal models, Sox17 levels in lung ECs were repressed in 26.7% of PAH patients (4 of 15), while those were robust in all 14 non-PAH controls. HGF levels in pulmonary arterioles were increased in 86.7% of patients with PAH (13 of 15), but none of the controls showed that pattern.

Conclusions:
The downregulation of Sox17 levels in pulmonary arterioles increases the susceptibility to PAH, particularly when exposed to hypoxia. Our findings suggest the reactive upregulation of HGF/c-Met signaling as a novel druggable target for PAH treatment.
Annotation Error Detection: Analyzing the Past and Present for a More Coherent Future
Authors: Klie Jan-Christoph , Webber Bonnie , Gurevych Iryna 
Published: October 2022

AbstractAnnotated data is an essential ingredient in natural language processing for training and evaluating machine learning models. It is therefore very desirable for the annotations to be of high quality. Recent work, however, has shown that several popular datasets contain a surprising number of annotation errors or inconsistencies. To alleviate this issue, many methods for annotation error detection have been devised over the years. While researchers show that their approaches work well on their newly introduced datasets, they rarely compare their methods to previous work or on the same datasets. This raises strong concerns on methods’ general performance and makes it difficult to assess their strengths and weaknesses. We therefore reimplement 18 methods for detecting potential annotation errors and evaluate them on 9 English datasets for text classification as well as token and span labeling. In addition, we define a uniform evaluation setup including a new formalization of the annotation error detection task, evaluation protocol, and general best practices. To facilitate future research and reproducibility, we release our datasets and implementations in an easy-to-use and open source software package.1
Joshua Fragment from Codex Climaci Rescriptus: A New Edition Based on the Multispectral Images
Authors: Malik Peter 
Published: October 2022

Abstract
This article offers a new edition of the LXX Joshua portion of Codex Climaci Rescriptus, an important, though somewhat neglected, Sinaitic Palimpsest. The edition is based on the post-processed multispectral images, produced by Early Manuscripts Electronic Library in cooperation with the Lazarus Project. The new technology has aided in correcting various errors in the editio princeps and uncovering hitherto unseen textual and paratextual elements. Moreover, the results of radiocarbon analysis have been factored into the dating of the fragment, resulting in a new proposal for its date of origin.
The Problem of Population Exchange, Mübadele through Deer Myths: A Greek Village in Anatolia, Livera
Authors: Kaya Nilay 
Published: October 2022

Abstract
In Anatolian and Turkish culture, since Shamanic times, deer has often been considered as sacred, rather than a game animal. Through this perspective, many deer-related narratives were formed and became a part of the folklore. This motif can also be seen in the modern narratives of Turkish literature. Necati Cumalı’s play, Yaralı Geyik (The Wounded Deer, 1979) based on a folk ballad, tells the story of a deer hunt and the curse of that deer upon people. Another example, Murathan Mungan’s play, Geyikler ve Lanetler (Deer and Curses, 1992) again nourished by folkloric tradition, focuses on a curse caused by a deer that is hunted during her pregnancy. This article focuses on a more contemporary narrative, Yusuf Bulut’s story Livera Geyikleri (The Deer of Livera, 2011) which uses the same pattern too. However this time a new element is added considering the ‘function’ of the myth, stressing a socio-historical problem, which is mübadele. For the population exchange between the Greek and Turkish people in 1923 shows itself as the main thematic concern in The Deer of Livera, how the story benefits from the possibilities of myth will be questioned in the article and an English translation of the story will be presented.
Prayer on the Prophet between Devotion and Scholarship
Authors: Petrone Michele 
Published: October 2022

Abstract
Prayer on the Prophet constitutes a common practice for all Muslims, often based on collections of taṣliyas that started appearing from the 14th century. This study aims at tracing the early developments of this literature, from jurisprudential works on the liceity and merits of the practice, to the naissance of new and articulated forms of prayer. This will also help detecting the role played by the institutionalization of Sufism in shaping the approach to the figure of the Prophet outside Sufi circles.
Pharmaco-fUS in cognitive impairment: Lessons from a preclinical model
Authors: Vidal Benjamin , Pereira Mickaël , Valdebenito Marco , Vidal Louis , Mouthon Franck , Zimmer Luc , Charvériat Mathieu , Droguerre Marine 
Published: October 2022

Background: There is an urgent need to understand and reverse cognitive impairment. The lack of appropriate animal models combined with the limited knowledge of pathophysiological mechanisms makes the development of new cognition-enhancing drugs complex. Scopolamine is a pharmacologic agent which impairs cognition and functional imaging in a wide range of animal species, similarly to what is seen in cognitive impairment in humans. Methods: In this study, using a functional ultrasound (fUS) neuroimaging technique, we monitored the impact of donepezil (DPZ), a potent acetylcholinesterase inhibitor and first-line treatment in patients with mild to moderate Alzheimer's disease, in a scopolamine-induced mouse model. Results: We demonstrated that despite its low impact on the cerebral blood volume (CBV) signal, scopolamine injection produced an overall decrease in functional connectivity between various brain areas. In addition, we revealed that DPZ induced a strong decrease in CBV signal without causing a difference in functional connectivity. Conclusion: Finally, our work highlighted that DPZ counteracted the impact of scopolamine on functional connectivity changes and confirmed the interest of using pharmaco-fUS imaging on cognitive disorders, both in frequent and rare neurological disorders.
Indian National Army: Netaji’s Secret Service
Authors: Roy Purabi 
Published: October 2022

Netaji’s Secret Service ‘Indian National Army’ essentially revolutionary organisation. It is well known the leftist played a crucial role in Subhas Bose getting elected as the President of the Tripuri Congress. In 1939 found the Left Consolidation Committee (LCC), but the tenuous coalition of the leftists in the Committee soon broke but CPI remained with Bose. However, after the Second World War broke out, Bose decided to leave India. The Communists helped Subhas in his escape; the main operator was Achhar Singh Chhina, who was best known by the Soviets as Larkin, Akbar Mia of Forward Bloc and Ajoy Ghosh of CPI. Bose’s after the escape to contact the Soviet leaders for enlisting them as India’s ally, was also helped by the communists. In the War theatre, Subhas Bose Was in favour of Link. Before his departure, All India Revolutionary Committee code-named ‘MARY’ in Delhi communicated with Kabul link station codenamed ‘OlIVER’ and with German link codenamed ‘TOM’. T. Holt Writes ‘channel “SILVER” was one of the great deception double agent channels of the war, real name Bhagat Ram Talwar’. 1 ‘SILVER’ the game Master, one of the closest person of Bose, was a communist, a Master of disguise, Knowledgeable about the various revolutionaries Movements in India. Silver kept the soviet posted on his work as the Link between the Axis legation in Kabul and Bose sympathisers in India. Silver’s intelligence system as a high-grade source. But Silver remained a Communist first and foremost, and whenever he entered Afghanistan, practical control passed to the Soviets. Eventually Bose could make his way to Rangoon where a new arrangement was made by the Axis. Subhas codenamed ‘RHINO’ sponsored by the Japanese and codename ‘ELEPHANT’ sponsored by the Germans to remain in touch with ‘MARY’ in Delhi. Netaji set up a pro-Axis Provisional Government of Free India in Andaman and Nicobar Islands. PG operated successfully military deception plans with military intelligent tactics. Netaji began to broadcast anti-British Propaganda as the Voice of Azad Hind. He made it clear that neither his armed forces nor his Azad Hind Radio Service could be used for anti-Soviet purposes. Unfortunately, the strategic deception role of Netaji remained secret for decades.
Improving Communication in Nursing Homes Using Plan-Do-Study-Act Cycles of an SBAR Training Program
Authors: Kay Samantha , Unroe Kathleen T. , Lieb Kristi M. , Kaehr Ellen W. , Blackburn Justin , Stump Timothy E. , Evans Russell , Klepfer Sarah , Carnahan Jennifer L. 
Published: October 2022

Background Incomplete communication between staff and providers may cause adverse outcomes for nursing home residents. The Situation-Background-Assessment-Recommendation (SBAR) tool is designed to improve communication around changes in condition (CIC). An adapted SBAR was developed for the Centers for Medicare and Medicaid Services demonstration project, OPTIMISTIC, to increase its use during a resident CIC and to improve documentation. Methods Four Plan-Do-Study-Act (PDSA) cycles to develop and refine successive protocol implementation of the OPTIMISTIC SBAR were deployed in four Indiana nursing homes. Use of SBAR, documentation quality, and participant surveys were assessed pre- and post-intervention implementation. Results OPTIMISTIC SBAR use and documentation quality improved in three of the four buildings. Participants reported improved collaboration between nurses and providers after SBAR intervention. Conclusion Successive PDSA cycles implementing changes in an OPTIMISTIC SBAR protocol for resident CIC led to an increase in SBAR use, improved documentation, and better collaboration between nursing staff and providers.
Individual and Community-Level Characteristics and Adherence to Specialty Medications
Authors: Kibbons Amanda M. , Moore Ryan , Choi Leena , Peter Megan , Zuckerman Autumn D. 
Published: October 2022

Background: Understanding risk factors for nonadherence can help specialty pharmacies optimize resources to prevent nonadherence and inform risk-stratification processes. Objective: To determine which individual and community-level characteristics are associated with nonadherence to specialty medications. Methods: We analyzed a cohort of patients enrolled in a prospective randomized controlled trial having filled a specialty medication at least 4 times in the previous 12 months with a proportion of days (PDC) covered < 0.90. We collected patient age, gender, race, medication administration type, therapy start date, home address, insurance type, and online patient portal status from the electronic health record. An ordinal logistic regression model was used to assess the association of nonadherence with individual and community-level patient characteristics. Results: Most patients were female (68%), white (82%), and held commercial insurance (58%) with a median age of 53 (interquartile range [IQR] 40, 64) years. Patients were mostly from the adult rheumatology (35%), multiple sclerosis (20%) and lipid (17%) clinics. Given a 10-year increase in age, patients had lower odds of having lower PDC (odds ratio [OR] = 0.82, 95% confidence interval [CI] = 0.71-0.94, P = 0.005). Patients on therapy greater than or equal to 1 year had half the odds of having lower PDC relative to patients on therapy less than 1 year (OR = 0.52, CI = 0.35 – 0.75, P < 0.001). No statistically significant associations were found between PDC and gender, race, insurance type, route of administration, clinic type, patient portal status, median income, percent receiving government assistance, or percent with no health insurance. Conclusion: Patients with younger age and shorter duration on treatment may be at-risk for lower adherence. Specialty pharmacies may benefit from targeting adherence interventions to these groups.
Availability of data for cost-effectiveness comparison of child vision and hearing screening programmes
Authors: Kik Jan , Heijnsdijk Eveline AM , Mackey Allison R , Carr Gwen , Horwood Anna M , Fronius Maria , Carlton Jill , Griffiths Helen J , Uhlén Inger M , Simonsz Huibert Jan ,   Country-Committees Joint-Partnership of the EUSCREEN Study Consortium
Published: October 2022

Objective For cost-effectiveness comparison of child vision and hearing screening programmes, methods and data should be available. We assessed the current state of data collection and its availability in Europe. Methods The EUSCREEN Questionnaire, conducted in 2017–2018, assessed paediatric vision and hearing screening programmes in 45 countries in Europe. For the current study, its items on data collection, monitoring and evaluation, and six of eleven items essential for cost-effectiveness analysis: prevalence, sensitivity, specificity, coverage, attendance and loss to follow-up, were reappraised with an additional questionnaire. Results The practice of data collection in vision screening was reported in 36% (N = 42) of countries and in hearing screening in 81% (N = 43); collected data were published in 12% and 35%, respectively. Procedures for quality assurance in vision screening were reported in 19% and in hearing screening in 26%, research of screening effectiveness in 43% and 47%, whereas cost-effectiveness analysis was performed in 12% for both. Data on prevalence of amblyopia were reported in 40% and of hearing loss in 77%, on sensitivity of screening tests in 17% and 14%, on their specificity in 19% and 21%, on coverage of screening in 40% and 84%, on attendance in 21% and 37%, and on loss to follow-up in 12% and 40%, respectively. Conclusions Data collection is insufficient in hearing screening and even more so in vision screening: data essential for cost-effectiveness comparison could not be reported from most countries. When collection takes place, this is mostly at a local level for quality assurance or accountability, and data are often not accessible. The resulting inability to compare cost-effectiveness among screening programmes perpetuates their diversity and inefficiency.
Midterm Follow-up of a Novel Algorithm for Nonoperative Weber B Ankle Fractures
Authors: Rooney Edward , Ruse Stacia , Talusan Paul , Holmes James , Walton David 
Published: October 2022

Background: Stable Weber B ankle fractures are routinely treated nonoperatively. Our group previously presented a novel algorithm that provides radiographic parameters guiding when Weber B ankle fractures can be treated nonoperatively.2 The purpose of this study is to evaluate the durability of those results with a minimum 5-year follow-up. Methods: All 51 patients who were included in the initial study were contacted by telephone and asked to return to clinic for repeat evaluation where American Orthopaedic Foot & Ankle Society (AOFAS) hindfoot, Olerud-Molander Ankle (OMA), and visual analog scale (VAS) scores were collected. Bilateral standing ankle radiographs were obtained and evaluated using the Kellgren-Lawrence grading scale for ankle arthritis. Results: Twenty-nine of 51 patients (56%) participated in this follow-up study with a mean follow-up of 6.8 (range 5.6-8) years. Average functional score results were as follows: AOFAS, 98.43; OMA score, 94.11; and VAS, 0.46. AOFAS scores improved by an average of 5 points between 1 year and 5 years ( P = .002); OMA and VAS scores were stable. All patients achieved union of their fracture on follow-up radiographs. Conclusion: Our findings demonstrate the durability of the previous study results conducted by Holmes et al,2 and support that appropriately selected patients can be treated nonoperatively using the study’s novel algorithm. This reinforces our theory that medial clear space widening on weightbearing radiographs up to 7 mm should be considered for nonoperative management. Level of Evidence: Level IV, case series.
Impact of Safe@Home on Placement and Permanency Outcomes: Results of a Quasi-Experimental Study
Authors: Reyes Lucia Miranda , Kaye Sarah 
Published: October 2022

This study assessed the effectiveness of Safe@Home, an in-home intervention to (1) prevent out-of-home placement for children at imminent risk of placement, and (2) minimize time in out-of-home care for children already in foster care. Using Coarsened Exact Matching, children who received Safe@Home were matched to a comparison group of children served before Safe@Home was available in their community. All children were determined by the child welfare agency to be unsafe and in need of immediate intervention. The matched samples (Safe@Home n = 510, Comparison n = 851) showed strong baseline equivalence on child age, race/ethnicity, previous history of child welfare involvement, and safety threats. Children who received Safe@Home experienced lower rate of out-of-home placements, higher rate of permanency with a parent (sustained for 12 months after the end of Safe@Home), fewer days in out-of-home care, and shorter time to case closure relative to children who received treatment as usual. There was no effect of Safe@Home on post-permanency outcomes of maltreatment and entry or re-entry after case closure.