bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electroweak phase transition in 2HDM under Higgs, Z-pole, and W precision measurements
Authors: Song Huayang , Su Wei , Zhang Mengchao 
Published: October 2022

Abstract
In this work we revisit the existence of a strong first order electroweak phase transition (SFOEWPT) and recent mW precision measurement in the Type-I and Type-II 2HDMs. The $$ \mathcal{O} $$
O
(100) GeV new scalars in 2HDMs are favored by SFOEWPT, which is necessary for electroweak baryogenesis, and observed mW shift as well. We find that under current constraints, both Type-I and Type-II 2HDM can explain the SFOEWPT, Z-pole, Higgs precision measurements and mW precision measurement of CDF-II at same time, and all these precision measurements are sensitive to heavy Higgs mass splitting in 2HDM. The allowed regions are ∆mA/C ∈ (−400, 400) GeV, tan β ∈ (1, 50), and ∆mA/C ∈ (−200, 300) GeV, tan β ∈ (1, 10) for Type-I and Type-II 2HDM respectively. Furthermore future lepton collider measurements on Higgs and Z boson properties can explore this scenario in more detail or even rule out it.
The infinite product of contraction semigroups on $$l^{1}({\mathbb {N}})$$ and $$l^{\infty }({\mathbb {N}})$$
Authors: Nieznaj Ernest 
Published: October 2022

AbstractI provide an example of a family of commuting contraction semigroups $$(e^{t B_{n}})_{n\in {\mathbb {N}}}$$

(

e

t

B
n

)

n
∈
N

defined on $$l^{1}({\mathbb {N}})$$

l
1

(
N
)

such that the product semigroup $$\prod _{n=1}^{\infty }e^{tB_{n}}$$

∏

n
=
1

∞

e

t

B
n

exists and has bounded generator. The infinite product of the corresponding family of adjoint semigroups $$(e^{t B_{n}^{*}})_{n\in {\mathbb {N}}}$$

(

e

t

B

n

∗

)

n
∈
N

defined on $$l^{\infty }({\mathbb {N}})$$

l
∞

(
N
)

also exists and its generator is bounded. I give explicit formulae for these generators. The results follow from a general convergence theorem for such semigroups proved in Arendt et al. (J Funct Anal 160: 524–542, 1998).
Iron and iron-related proteins in alcohol consumers: cellular and clinical aspects
Authors: Ferrao Kevin , Ali Najma , Mehta Kosha J. 
Published: October 2022

AbstractAlcohol-associated liver disease (ALD) is one of the most common chronic liver diseases. Its pathological spectrum includes the overlapping stages of hepatic steatosis/steatohepatitis that can progress to liver fibrosis and cirrhosis; both are risk factors for hepatocellular carcinoma. Moreover, ALD diagnosis and management pose several challenges. The early pathological stages are reversible by alcohol abstinence, but these early stages are often asymptomatic, and currently, there is no specific laboratory biomarker or diagnostic test that can confirm ALD etiology. Alcohol consumers frequently show dysregulation of iron and iron-related proteins. Examination of iron-related parameters in this group may aid in early disease diagnosis and better prognosis and management. For this, a coherent overview of the status of iron and iron-related proteins in alcohol consumers is essential. Therefore, here, we collated and reviewed the alcohol-induced alterations in iron and iron-related proteins. Reported observations include unaltered, increased, or decreased levels of hemoglobin and serum iron, increments in intestinal iron absorption (facilitated via upregulations of duodenal divalent metal transporter-1 and ferroportin), serum ferritin and carbohydrate-deficient transferrin, decrements in serum hepcidin, decreased or unaltered levels of transferrin, increased or unaltered levels of transferrin saturation, and unaltered levels of soluble transferrin receptor. Laboratory values of iron and iron-related proteins in alcohol consumers are provided for reference. The causes and mechanisms underlying these alcohol-induced alterations in iron parameters and anemia in ALD are explained. Notably, alcohol consumption by hemochromatosis (iron overload) patients worsens disease severity due to the synergistic effects of excess iron and alcohol.
Activation of autophagy triggers mitochondrial loss and changes acetylation profile relevant for mechanotransduction in bladder cancer cells
Authors: Jobst Maximilian , Kiss Endre , Gerner Christopher , Marko Doris , Del Favero Giorgia 
Published: October 2022

AbstractBladder cells are constantly exposed to multiple xenobiotics and bioactive metabolites. In addition to this challenging chemical environment, they are also exposed to shear stress originating from urine and interstitial fluids. Hence, physiological function of bladder cells relies on a high biochemical and biomechanical adaptive competence, which, in turn, is largely supported via autophagy-related mechanisms. As a negative side of this plasticity, bladder cancer cells are known to adapt readily to chemotherapeutic programs. At the molecular level, autophagy was described to support resistance against pharmacological treatments and to contribute to the maintenance of cell structure and metabolic competence. In this study, we enhanced autophagy with rapamycin (1–100 nM) and assessed its effects on the motility of bladder cells, as well as the capability to respond to shear stress. We observed that rapamycin reduced cell migration and the mechanical-induced translocation potential of Krüppel-like transcription factor 2 (KLF2). These effects were accompanied by a rearrangement of cytoskeletal elements and mitochondrial loss. In parallel, intracellular acetylation levels were decreased. Mechanistically, inhibition of the NAD + -dependent deacetylase sirtuin-1 (SIRT1) with nicotinamide (NAM; 0.1–5 mM) restored acetylation levels hampered by rapamycin and cell motility. Taken together, we described the effects of rapamycin on cytoskeletal elements crucial for mechanotransduction and the dependency of these changes on the mitochondrial turnover caused by autophagy activation. Additionally, we could show that targeted metabolic intervention could revert the outcome of autophagy activation, reinforcing the idea that bladder cells can easily adapt to multiple xenobiotics and circumvent in this way the effects of single chemicals.
Standardization of Trauma, General Surgical Morbidity and Mortality Conferences: Development and Dissemination of a “Toolkit” in Peru
Authors: Zavala Wong Gabriela , Rodriguez Castro Manuel J. , Huaman Egoavil Eduardo , Valderrama Roberto , Mock Charles N. , Herrera‐Matta Juan J. , Aragon Gianni , Peterson Ryan , Jin Ying , LaGrone Lacey N. 
Published: October 2022

AbstractBackgroundMorbidity and Mortality (M&M) conferences allow clinicians to review adverse events and identify areas for improvement. There are few reports of structured M&M conferences in low‐ and middle‐income countries and no report of collaborative efforts to standardize them.MethodsThe present study aims to gather general surgeons representing most of Peru's urban surgical care and, in collaboration, with trauma quality improvement experts develop a M&M conferences toolkit with the expectation that its diffusion impacts their reported clinical practice. Fourteen general surgeons developed a toolkit as part of a working group under the auspices of the Peruvian General Surgery Society. After three years, we conducted an anonymous written questionnaire to follow‐up previous observations of quality improvement practices.ResultsA four‐component toolkit was developed: Toolkit component #1: Conference logistics and case selection; Toolkit component #2: Documenting form; Toolkit component #3: Presentation template; and Toolkit component #4: Code of conduct. The toolkit was disseminated to 10 hospitals in 2016. Its effectiveness was evaluated by comparing the results of surveys on quality improvement practices conducted in 2016, before toolkit dissemination (101 respondents) and 2019 (105 respondents). Lower attendance was reported by surgeons in 2019. However, in 2019, participants more frequently described “improve the system” as the perceived objective of M&M conferences (70.5% vs. 38.6% in 2016; p < 0.001).ConclusionWe established a toolkit for the national dissemination of a standardized M&M conference. Three years following the initial assessment in Peru, we found similar practice patterns except for increased reporting of “system improvement” as the goal of M&M conferences.
Fine-Tuned Immune Antagonism and Nodule-Specific Cysteine-Rich Peptides Govern the Symbiotic Specificity Between Alfalfa Cultivars and Ensifer meliloti
Authors: Kang Wenjuan , Li Xiaolong , Zhang Xiaoyan , Shi Shangli 
Published: October 2022

AbstractAlfalfa expresses significantly distinct sets of genes in response to infection with different rhizobial strains at the below species level (i.e., biotype or strain). However, differences in the transcriptomic profiles of two alfalfa cultivars nodulated by a single rhizobium strain have been largely unexamined. In this study, comparative RNA-seq analysis of two alfalfa cultivars,Medicago sativacv. Gannong No. 3 (G3) and cv. Gannong No. 9 (G9) inoculated with oneEnsifer melilotistrain LL2, with varying symbiotic performance, was conducted, followed by hub gene interaction network construction based on weighted gene co-expression network analysis (WGCNA). The G9-LL2 symbiotic system showed better nodule formation, nitrogen fixation, and growth characteristics than the G3-LL2 system. Compared with the non-inoculated control, the LL2-inoculated G9 plants (10,053) produced more differentially expressed genes (DEGs) than the LL2-inoculated G3 plants (7112). A group of 227 genes displayed completely distinguished expression in G9 (6.63 < log2(FC) < 15.45) and G3 (‒ 3.05 < log2(FC) < 12.05), which are primarily involved in encoding nodule-specific cysteine-rich peptides (NCRs), nodulin, and leghemoglobin. Although genes with predicted roles in nitrogen metabolism were primarily upregulated and almost all of those in ubiquitin-mediated proteolysis and plant–pathogen interaction were suppressed, interestingly, a consistently higher expression level measured by log2(FC) was observed in G9 plants. Hub gene interaction networks showed that NCRs, late nodulin, and genes related to plant immunity (TIR-NBS-LRR, defensin, thioredoxin, thionine, and polygalacturonase) regulate other genes at the source node positions. After successful initiation of nodulation in both alfalfa cultivars G3 and G9 byE. melilotistrain LL2, G9 achieved preferable outcomes of rhizobia–alfalfa symbiosis by equilibrating the antagonism and compatibility of plant immunity. It elevated PTI, suppressed defense and ETI, and enhanced nitrogen fixation and utilization efficiency by inducing the expression of genes encoding NIN, NFH1, LysM-RLK, LRP, NCRs, nodulin, and leghemoglobin. Hub genes were predominantly associated with highly specific rhizobia–alfalfa symbiosis positively governed by NCRs and fine-tuned immune antagonism, comprising NCRs, late nodulin, and TIR-NBS-LRR. These findings provide insights into the genetic mechanisms underlying the modification and efficient utilization of semi-compatible and incompatible rhizobial resources.
Influence of interrupted versus continuous suture technique on intestinal anastomotic leakage rate in patients with Crohn’s disease — a propensity score matched analysis
Authors: Mittelstädt Anke , von Loeffelholz Tobias , Weber Klaus , Denz Axel , Krautz Christian , Grützmann Robert , Weber Georg F. , Brunner Maximilian 
Published: October 2022

Abstract
Purpose
Intestinal anastomosis is a crucial step in most intestinal resections, as anastomotic leakage is often associated with severe consequences for affected patients. There are especially two different techniques for hand-sewn intestinal anastomosis: the interrupted suture technique (IST) and the continuous suture technique (CST). This study investigated whether one of these two suture techniques is associated with a lower rate of anastomotic leakage.

Methods
A retrospective review of 332 patients with Crohn’s disease who received at least one hand-sewn colonic anastomosis at our institution from 2010 to 2020 was performed. Using propensity score matching 183 patients with IST were compared to 96 patients with CST in regard to the impact of the anastomotic technique on patient outcomes.

Results
Overall anastomotic leakage rate was 5%. Leakage rate did not differ between the suture technique groups (IST: 6% vs. CST: 3%, p = 0.393). Multivariate analysis revealed the ASA score as only independent risk factor for anastomotic leakage (OR 5.3 (95% CI = 1.2–23.2), p = 0.026). Suture technique also showed no significant influence on morbidity and the re-surgery rate in multivariate analysis.

Conclusion
Our data suggest that the chosen suture technique (interrupted vs. continuous) has no influence on postoperative outcome, especially on anastomotic leakage rate. This finding should be confirmed by a randomized controlled trial.
Volumetry improves the assessment of the vestibular aqueduct size in inner ear malformation
Authors: Weiss Nora M. , Breitsprecher Tabita M. , Pscheidl Alexander , Bächinger David , Volkenstein Stefan , Dazert Stefan , Mlynski Robert , Langner Sönke , Roland Peter , Dhanasingh Anandhan 
Published: October 2022

Abstract
Objectives
Enlarged vestibular aqueduct (EVA) is a common finding associated with inner ear malformations (IEM). However, uniform radiologic definitions for EVA are missing and various 2D-measurement methods to define EVA have been reported. This study evaluates VA volume in different types of IEM and compares 3D-reconstructed VA volume to 2D-measurements.

Methods
A total of 98 high-resolution CT (HRCT) data sets from temporal bones were analyzed (56 with IEM; [cochlear hypoplasia (CH; n = 18), incomplete partition type I (IPI; n = 12) and type II (IPII; n = 11) and EVA (n = 15)]; 42 controls). VA diameter was measured in axial images. VA volume was analyzed by software-based, semi-automatic segmentation and 3D-reconstruction. Differences in VA volume between the groups and associations between VA volume and VA diameter were assessed. Inter-rater-reliability (IRR) was assessed using the intra-class-correlation-coefficient (ICC).

Results
Larger VA volumes were found in IEM compared to controls. Significant differences in VA volume between patients with EVA and controls (p < 0.001) as well as between IPII and controls (p < 0.001) were found. VA diameter at the midpoint (VA midpoint) and at the operculum (VA operculum) correlated to VA volume in IPI (VA midpoint: r = 0.78, VA operculum: r = 0.91), in CH (VA midpoint: r = 0.59, VA operculum: r = 0.61), in EVA (VA midpoint: r = 0.55, VA operculum: r = 0.66) and in controls (VA midpoint: r = 0.36, VA operculum: r = 0.42). The highest IRR was found for VA volume (ICC = 0.90).

Conclusions
The VA diameter may be an insufficient estimate of VA volume, since (1) measurement of VA diameter does not reliably correlate with VA volume and (2) VA diameter shows a lower IRR than VA volume. 3D-reconstruction and VA volumetry may add information in diagnosing EVA in cases with or without additional IEM.
Prognostic factors in patients with acute mesenteric ischemia—novel tools for determining patient outcomes
Authors: Sinz Stefanie , Schneider Marcel A. , Graber Simon , Alkadhi Hatem , Rickenbacher Andreas , Turina Matthias 
Published: October 2022

Abstract
Background
Acute mesenteric ischemia (AMI) is a devastating disease with poor prognosis. Due to the multitude of underlying factors, prediction of outcomes remains poor. We aimed to identify factors governing diagnosis and survival in AMI and develop novel prognostic tools.

Methods
This monocentric retrospective study analyzed patients with suspected AMI undergoing imaging between January 2014 and December 2019. Subgroup analyses were performed for patients with confirmed AMI undergoing surgery. Nomograms were calculated based on multivariable logistic regression models.

Results
Five hundred and thirty-nine patients underwent imaging for clinically suspected AMI, with 216 examinations showing radiological indication of AMI. Intestinal necrosis (IN) was confirmed in 125 undergoing surgery, 58 of which survived and 67 died (median 9 days after diagnosis, IQR 22). Increasing age, ASA score, pneumatosis intestinalis, and dilated bowel loops were significantly associated with presence of IN upon radiological suspicion. In contrast, decreased pH, elevated creatinine, radiological atherosclerosis, vascular occlusion (versus non-occlusive AMI), and colonic affection (compared to small bowel ischemia only) were associated with impaired survival in patients undergoing surgery. Based on the identified factors, we developed two nomograms to aid in prediction of IN upon radiological suspicion (C-Index = 0.726) and survival in patients undergoing surgery for IN (C-Index = 0.791).

Conclusion
As AMI remains a condition with high mortality, we identified factors predicting occurrence of IN with suspected AMI and survival when undergoing surgery for IN. We provide two new tools, which combine these parameters and might prove helpful in treatment of patients with AMI.
A global survey on the utilization of cryotherapy and compression therapy for the prevention of chemotherapy-induced peripheral neuropathy
Authors: Chan Alexandre , Elsayed Amna , Ng Ding Quan , Ruddy Kathryn , Loprinzi Charles , Lustberg Maryam 
Published: October 2022

Abstract

Background
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect that is highly prevalent among cancer patients undergoing chemotherapy. There is a growing use of cryotherapy (CryTx) and compression therapy (ComTx) to prevent CIPN at cancer centers worldwide. In this study, we examined the awareness and recommendation of these modalities and evaluated factors associated with awareness. In addition, we investigated the type of technology utilized, barriers to implementation, and perceived adverse events of CryTx and ComTx.

Methods
Active members of the Multinational Association of Supportive Care of Cancer (MASCC) were invited to complete an electronic survey that was sent via SurveyMonkey between September and October 2021. The survey assessed participants’ awareness, recommendation, usage, barriers to utilization, and perceived adverse events of CryTx and ComTx. Descriptive statistics and multiple logistic regression were utilized to analyze findings.

Results
Out of 184 participants, 70.1% were physicians, 73.4% had over 10 years of practice, and 49.5% were practicing in an outpatient setting. While more than half (63.3%) of participants indicated awareness of CryTx for taxane-induced peripheral neuropathy, less than a quarter (22.8%) indicated recommendation in their practice setting. Factors associated with higher awareness of CryTx for patients receiving taxanes include living in Europe (OR = 2.69, 95% CI [1.28–5.64], p = 0.009), not practicing in an inpatient setting (OR = 3.15, 95% CI [1.45–6.85], p = 0.004), and self-identifying as non-physician (OR = 2.40, 95% CI [1.03–4.37], p = 0.041). Commercial cooling (31.5%) and compression (16.8%) gloves and socks were the most used modalities for CryTx and ComTx, respectively. The most identified barriers to CryTx and ComTx utilization include insufficient evidence (53.5%), logistics (34.8%), and patient discomfort (23.4%). Redness/irritation of skin (27.7%) and numbness/tingling (24.5%) accounted for about half of the perceived adverse events associated with use of CryTx and ComTx.

Conclusion
Results of our global survey illustrated that there are varying modes in the delivery of CryTx and ComTx among cancer centers around the world. Education of the utilization of CryTx and ComTx, in addition to efficacy and implementation studies, is needed to close the gap between awareness and implementation in clinical practice.
Therapeutic strategies for retention of cranioplasty titanium mesh after mesh exposure
Authors: Zhao Yao-Hua , Feng Yu-Hong , Deng Hai-Tao , Huang Wei-Qi , Xu Li-Hong , Meng Xian-Ping , Xie Xu-Gang 
Published: October 2022

Abstract
Background
Titanium mesh exposure after cranioplasty is a possible complication and is usually managed by mesh removal and flap transfer, but the advantages of the rigid prosthesis are then lost. This study aimed to present our experience with negative pressure wound therapy combined with soft tissue dilation for retaining the titanium mesh in patients with mesh exposure after cranioplasty.

Methods
This retrospective study included patients treated between 01/2016 and 05/2019 at the Jiangyin Hospital Affiliated to Southeast University School of Medicine. The wound was cleaned, and a cystic space was created for the tissue dilator, which was used with a self-designed negative pressure dressing. After the target dilation was achieved, the repair was conducted while retaining the titanium mesh.

Results
Eight patients were included (seven males and one female; 53.6 ± 8.8 (range, 43–65) years of age). The exposed mesh area ranged from 1 × 1 to 4 × 5.5 cm. The thinning scalp area around the exposed mesh ranged from 3.6 × 3.8 to 4 × 5.5 cm. Five patients had positive wound cultures and received sensitive antibiotics. The dilator embedding time was 20–28 days. The time of negative pressure wound therapy was 25–33 days. The hospital stay was 30–41 days. Primary wound healing was achieved in all eight patients. There were no signs of recurrence after 6–18 months of follow-up. The cranial CT scans were unremarkable.

Conclusions
Negative pressure wound therapy combined with soft tissue dilation for exposed titanium mesh after cranioplasty might help retain the titanium mesh.
A novel framework for generalizing dynamic movement primitives under kinematic constraints
Authors: Sidiropoulos Antonis , Papageorgiou Dimitrios , Doulgeri Zoe 
Published: October 2022

AbstractIn this work, we propose a novel framework for generalizing a desired trajectory pattern, encoded using Dynamic Movement Primitives (DMP), subject to kinematic constraints. DMP have been extensively used in robotics for encoding and reproducing kinematic behaviours, thanks to their generalization, stability and robustness properties. However, incorporating kinematic constraints has not yet been fully addressed. To this end, we design an optimization framework, based on the DMP formulation from our previous work, for generalizing trajectory patterns, encoded with DMP subject to kinematic constraints, considering also time-varying target and time duration, via-point and obstacle constraints. Simulations highlight these properties and comparisons are drawn with other approaches for enforcing constraints on DMP. The usefulness and applicability of the proposed framework is showcased in experimental scenarios, including a handover, where the target and time duration vary, and placing scenarios, where obstacles are dynamically introduced in the scene.