bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk and prognostic factors of replantation failure in patients with severe traumatic major limb mutilation
Authors: Gao Chang , Yang Ling , Ju Jihui , Gao Ye , Zhang Keran , Wu Mingming , Yang Lijuan , Lu Xiaoting , Hou Ruixing , Guo Qiang 
Published: January 2022

Abstract
Purpose
Traumatic mutilation of major limbs can result in limb loss, motor disability, or death. Patients who had replantation failure needed to undergo additional surgeries (even amputation) and had a longer length of hospital stay. Here, we determined the risk and prognostic factors of replantation failure in patients with traumatic major limb mutilation.

Methods
This retrospective study included adult inpatients with severed traumatic major limb mutilation who underwent replantation from Suzhou Ruixing Medical Group from October 18, 2016 to July 31, 2020. Demographic, and clinical characteristics including traumatic conditions, laboratory findings, mangled extremity severity scores (MESS), treatments, and outcomes of the patients were collected. Data were used to analyze predictors and risk factors for replantation failure.

Results
Among the 66 patients, 48 (72.7%) were males, the median age was 47.0 years old. Replantation failure occurred in 48 patients (72.7%). The area under the curve of the joint prediction of lactic acid on admission, 72-h cumulative fluid balance, and albumin level immediately postoperatively was 0.838 (95% confidence interval [CI], 0.722–0.954; P < 0.001) with a sensitivity of 89.7% and a specificity of 69.2%. Lower limb trauma (odds ratio [OR] 8.65, 95% CI 1.64–45.56, P = 0.011), mangled extremity severity scores (OR 2.24, 95% CI 1.25–4.01, P = 0.007), and first 72-h cumulative fluid balance > 4885.6 mL (OR 10.25, 95% CI 1.37–76.93, P = 0.024) were independent risk factors for replantation failure.

Conclusions
Lower limb trauma, mangled extremity severity scores, and cumulative water balance were associated with replantation failure, implying that fluid management is necessary for major limb salvage. More studies are needed to explore the predictive power of indicators related to tissue oxygenation and wound healing for replantation failure.
Role of renin–angiotensin system antagonists on long-term mortality post-percutaneous coronary intervention in reduced and preserved ejection fraction
Authors: Prosser Hamish C. , Peck Kah Yong , Dinh Diem , Roberts Louise , Chandrasekhar Jaya , Brennan Angela , Duffy Stephen J. , Clark David , Ajani Andrew E. , Oqueli Ernesto , Sebastian Martin , Reid Christopher M. , Freeman Melanie , Sajeev Jithin K. , Teh Andrew W. 
Published: January 2022

Abstract
Aims
The use of angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II-receptor blockers (ARBs) post-myocardial infarction (MI) is supported by evidence based on trials performed in the thrombolysis era. This was prior to primary percutaneous coronary intervention (PCI) being routine practice, and with little direct evidence for the use of these medications in patients with preserved left ventricular (LV) function. This study sought to determine whether there is an association between ACEi/ARB use after PCI for acute coronary syndrome (ACS) and long-term all-cause mortality, with a particular focus on patients with preserved LV function.

Methods
This multicentre, observational study evaluated prospectively collected data of 21,388 patients (> 18 years old) that underwent PCI for NSTEMI and STEMI between 2005 and 2018, and were alive at 30 day follow-up.

Results
In total, 83.8% of patients were using ACEi/ARBs. Kaplan–Meier analysis demonstrated ACEi/ARB use was associated with a significantly lower mortality in the entire cohort (15.0 vs. 22.7%; p < 0.001) with a mean follow-up of 5.58 years; and independently associated with 24% lower mortality by Cox proportional hazards modelling (HR 0.76, CI 0.67–0.85, p < 0.001). ACEi/ARB therapy was also associated with significantly lower mortality in patients with reduced or preserved LV function, with greater survival benefit with worse LV dysfunction.

Conclusion
ACEi/ARB therapy post-PCI is associated with significantly lower long-term mortality in patients with reduced and preserved LV function. These findings provide contemporary evidence for using these agents in the current era of routine primary PCI, including those with preserved EF.

Graphical abstract
Accelerated reactive transport simulations in heterogeneous porous media using Reaktoro and Firedrake
Authors: Kyas Svetlana , Volpatto Diego , Saar Martin O. , Leal Allan M. M. 
Published: January 2022

AbstractThis work investigates the performance of the on-demand machine learning (ODML) algorithm introduced in Leal et al. (Transp. Porous Media133(2), 161–204, 2020) when applied to different reactive transport problems in heterogeneous porous media. This approach was devised to accelerate the computationally expensive geochemical reaction calculations in reactive transport simulations. We demonstrate that even with a strong heterogeneity present, the ODML algorithm speeds up these calculations by one to three orders of magnitude. Such acceleration, in turn, significantly advances the entire reactive transport simulation. The performed numerical experiments are enabled by the novel coupling of two open-source software packages: Reaktoro (Leal 2015) and Firedrake (Rathgeber et al. ACM Trans. Math. Softw.43(3), 2016). The first library provides the most recent version of the ODML approach for the chemical equilibrium calculations, whereas, the second framework includes the newly implemented conservative Discontinuous Galerkin finite element scheme for the Darcy problem, i.e., the Stabilized Dual Hybrid Mixed(SDHM) method Núñez et al. (Int. J. Model. Simul. Petroleum Industry, 6, 2012).
The impact of FDI on income inequality in Egypt
Authors: Rezk Hebatalla , Amer Goma , Fathi Nahla , Sun Sizhong 
Published: January 2022

AbstractThis study examines the impact of inward foreign direct investment (FDI) on income inequality in Egypt over the period from 1975 to 2017. We find that a one per cent increase in FDI inflows (as a percentage of gross fixed capital formation) results in 0. 0188 reduction of the Gini coefficient. The finding is robust to different specifications of the empirical model and potential endogeneity of FDI inflows. The negative impact of FDI inflows suggests that Egyptian policymakers shall continue and strengthen the open-door policy, which has the added benefit of improving income inequality.
Comparison of co-administration of amiodarone and rivaroxaban to co-administration of dronedarone and rivaroxaban for hemorrhage risks after atrial fibrillation ablation
Authors: Zhang Peng , Wang Maojing , Liu Wenheng , Sun Pin , Cai Shanglang , Pan Yaqi , Zhao Qing 
Published: January 2022

Abstract
Purpose
To investigate whether co-administration of antiarrhythmic dronedarone and anticoagulant rivaroxaban would increase the risks of hemorrhage after atrial fibrillation (AF) ablation.

Methods
A total of 100 patients with AF who underwent radiofrequency catheter ablation (CA) in the Department of Cardiology, the Affiliated Hospital of Qingdao University from 2019–12 to 2020–11 were included. Patients were divided into an oral dronedarone and rivaroxaban group (D-R group, N = 50) and an oral amiodarone and rivaroxaban group (A-R group, N = 50) according to the postoperative antiarrhythmic and anticoagulation strategies. Patients in 2 groups were given propensity score matching (PSM) to obtain a sample with balanced inter-group covariates. A retrospective observational study was conducted. After 3 months of follow-up, the incidence of clinically relevant non-major bleeding (CRNMB), major hemorrhages, and early AF recurrence was observed.

Results
After PSM, 41 patients were included in each group. With similarly distributed baseline characteristics and ablation characteristics after PSM, the CRNMB rate after AF ablation was significantly higher in the D-R group than in the A-R group (26.8% versus 7.3%, P = 0.02), and no major hemorrhages were detected in both groups. No significant difference was observed in the sinus rhythm maintenance rate between the D-R group and the A-R group (26.8% vs. 22.0%, P = 0.43).

Conclusions
Compared to co-administration of amiodarone and rivaroxaban, co-administration of dronedarone and rivaroxaban increases the risk of CRNMB but it does not increase the risk of major hemorrhages in blanking period after AF ablation.
Resource analysis of quantum computing with noisy qubits for Shor’s factoring algorithms
Authors: Ha Jinyoung , Lee Jonghyun , Heo Jun 
Published: January 2022

AbstractWe decompose two implementations of Shor’s algorithm for prime factorization into universal gate units at the logical level and predict the number of physical qubits and execution time when surface codes are used. Logical qubit encoding using a rotated surface code and logical qubits with all-to-all connectivity are assumed. We express the number of physical qubits and execution time in terms of the bit length of the number to be factorized and error rate of the physical quantum gate. We confirm the relationship between the number of qubits and the execution time by analyzing two algorithms using various bit lengths and physical gate error rates .
Chloride accumulation in aboveground biomass of three macrophytes (Phragmites australis, Juncus maritimus, and Typha latifolia) depending on their growth stages and salinity exposure: application for Cl− removal and phytodesalinization
Authors: Delattre Emmanuel , Techer Isabelle , Reneaud Benjamin , Verdoux Patrick , Laffont-Schwob Isabelle , Prohin Philippe 
Published: January 2022

Abstract

Anthropogenic activities can be the source of saline solid wastes that need to be treated to reduce their salt load to meet the purposes of reuse, valorization or storage. In this context, chloride remediation can be achieved using high-salt accumulating plants. However, there is very limited information on the comparative potential of different species in the same environment, and only scarce data concerning their efficiency as a function of growth stage. In order to rationalize these selection criteria, three macrophytes i.e., common reed (Phragmites australis), sea rush (Juncus maritimus), and cattail (Typha latifolia), were cultivated at two growth stages (6-months old and 1-year old) for 65 days in Cl− spiked substrates (from 0 up to 24 ‰ NaCl). The plants’ survival and potential capacity for removal of Cl− from substrates and accumulation in shoots were investigated. For the three studied species, mature and juvenile plants display a high tolerance to salinity. However, mature specimens with higher shoot biomass and Cl− contents are capable of greater chloride removal than juvenile plants. The sole exception is P. australis which displays just the same phytoremediation potential for both mature and juvenile specimens. Moreover, P. australis has the lowest potential when compared with other species, being 1.5 and 3 times lower than for J. maritimus and T. latifolia. When considering the plant growth and the shoot biomass production, chloride removal rates from the substrate point that mature J. maritimus should preferentially be used to design an operational chloride remediation system. The results highlight the relevance of considering the growth stage of plants used for Cl− removal.

Highlights
1) Mature and juvenile specimens of J. maritimus, P. australis, and T. latifolia have high salinity tolerance in solid media spiked up to 24 ‰ NaCl.
2) Mature plants have generally better Cl− removal and phytoremediation performances than juvenile specimens.
3) J. maritimus is the most effective species for chloride phytoremediation with high survival and high Cl− sequestration in shoots.
4) T. latifolia has high Cl− removal in shoots and good remediation capacities but also shows sign of stress.
5) P. australis shows low Cl− sequestration and is a poor candidate for chloride remediation from substrate.
D609 inhibition of phosphatidylcholine-specific phospholipase C attenuates prolonged insulin stimulation-mediated GLUT4 downregulation in 3T3-L1 adipocytes
Authors: Ma Jinhui , Zhang Xu , Song Yankun , Qin Yan , Tan Yinghui , Zheng Lishuang , Cheng Baoqian , Xi Xin 
Published: January 2022

Abstract
Glucose uptake is stimulated by insulin via stimulation of glucose transporter 4 (GLUT4) translocation to the plasma membrane from intracellular compartments in adipose tissue and muscles. Insulin stimulation for prolonged periods depletes GLUT4 protein, particularly in highly insulin-responsive GLUT4 storage vesicles. This depletion mainly occurs via H2O2-mediated retromer inhibition. However, the post-receptor mechanism of insulin activation of oxidative stress remains unknown. Here, we show that phosphatidylcholine-specific phospholipase C (PC-PLC) plays an important role in insulin-mediated downregulation of GLUT4. In the study, 3T3-L1 adipocytes were exposed to a PC-PLC inhibitor, tricyclodecan-9-yl-xanthogenate (D609), for 30 min prior to the stimulation with 500 nM insulin for 4 h, weakening the depletion of GLUT4. D609 also prevents insulin-driven H2O2 generation in 3T3-L1 adipocytes. Exogenous PC-PLC and its product, phosphocholine (PCho), also caused GLUT4 depletion and promoted H2O2 generation in 3T3-L1 adipocytes. Furthermore, insulin-mediated the increase in the cellular membrane PC-PLC activity was observed in Amplex Red assays. These results suggested that PC-PLC plays an important role in insulin-mediated downregulation of GLUT4 and that PCho may serve as a signaling molecule.
Composition optimization, high-temperature stability, and thermal cycling performance of Sc-doped Gd2Zr2O7 thermal barrier coatings: Theoretical and experimental studies
Authors: Guo Lei , Li Bowen , Cheng Yuxian , Wang Lu 
Published: January 2022

AbstractSc was doped into Gd2Zr2O7 for expanding the potential for thermal barrier coating (TBC) applications. The solid solution mechanism of Sc in the Gd2Zr2O7 lattice, and the mechanical and thermophysical properties of the doped Gd2Zr2O7 were systematically studied by the first-principles method, based on which the Sc doping content was optimized. Additionally, Sc-doped Gd2Zr2O7 TBCs with the optimized composition were prepared by air plasma spraying using YSZ as a bottom ceramic coating (Gd-Sc/YSZ TBCs), and their sintering behavior and thermal cycling performance were examined. Results revealed that at low Sc doping levels, Sc has a large tendency to occupy the lattice interstitial sites, and when the doping content is above 11.11 at%, Sc substituting for Gd in the lattice becomes dominant. Among the doped Gd2Zr2O7, the composition with 16.67 at% Sc content has the lowest Pugh’s indicator (G/B) and the highest Poisson ratio (σ) indicative of the highest toughness, and the decreasing trends of Debye temperature and thermal conductivity slow down at this composition. By considering the mechanical and thermophysical properties comprehensively, the Sc doping content was optimized to be 16.67 at%. The fabricated Gd-Sc coatings remain phase and structural stability after sintering at 1400 °C for 100 h. Gd-Sc/YSZ TBCs exhibit excellent thermal shock resistance, which is related to the good thermal match between Gd-Sc and YSZ coatings, and the buffering effect of the YSZ coating during thermal cycling. These results revealed that Sc-doped Gd2Zr2O7 has a high potential for TBC applications, especially for the composition with 16.67 at% Sc content.
Towards the efficient modelling of trapped air pockets during squeeze flow
Authors: Müller Michael , Willenbrock Steffen , Stahl Lukas , Vallée Till , Fricke Holger 
Published: January 2022

AbstractIn most bonding processes, an adhesive is applied to a substrate in a specific pattern before the second substrate is subsequently pressed against it. During this, the adhesive flows in such a way that, ideally, it completely fills the joint. In practice, however, areas with entrapped air frequently remain in the bonded adhesive layer. Within the scope of a research project, these flows are systematically analyzed in order to identify optimal initial application patterns for the adhesive and substrate geometry to minimise such risks. For this purpose, the authors use an efficient flow model, the partially filled gaps model (PFGM), extended in this study to include the functionality of trapped air pockets. Depending on the volume fractions of air and adhesive, the flow of both phases is computed. Therefore, the model is introduced and fully described, benchmarked with respect to its plausibility and functionality, and results obtained are compared with a CFD calculation. Thereafter, the functionality of openings and closings of the pockets are analyzed. Lastly, the model is then applied to a real scenario created with a Hele–Shaw cell measurement. The benchmark as well as the comparison with the measurement results show the high potential of this technique.
The Natural History of Non-operatively Managed Legg–Calvé–Perthes’ Disease
Authors: Ailabouni Ramez , Zomar Bryn O. , Slobogean Bronwyn L. , Schaeffer Emily K. , Joseph Benjamin , Mulpuri Kishore 
Published: January 2022

Abstract
Background
The purpose of this study was to examine the evolution of Legg–Calvé–Perthes’ disease (LCPD) among children from British Columbia (BC), Canada who were treated non-operatively and to compare the results to a previously conducted study in India.

Methods
This was a retrospective review of patients treated non-operatively for LCPD in BC between 1990 and 2006 compared with a cohort from India. Demographic and treatment information were collected from medical records. Radiographs were assigned modified Waldenstrom, Catterall, Salter–Thompson and Herring classifications and intra- and interobserver reliability were assessed. We evaluated epiphyseal extrusion (EE) and metaphyseal width (MW), and assessed radiographs using the Mose and modified Stulberg classifications.

Results
102 hips (90 patients) had radiographs available for evaluation. 95% of the BC cohort presented as Waldenstrom stages I and II, whereas, 90% of the Indian cohort presented as IIIa. Final EE was similar for both groups (BC 26.8%, India 27.3%) and final MW was 119% in both groups. Modified Waldenstrom and Herring classifications had substantial intra- and interobserver reliability, while Salter–Thompson and Catterall classifications had moderate agreement at best. Most hips were Catterall IV (80%) and Herring C (89%) for the BC cohort compared to only 44% and 43% of Indian hips, respectively. Most hips were irregular according to the Mose classification (BC 43%, India 52%) and aspherical according to the Stulberg classification (BC 78%).

Conclusions
We found similar radiographic progression and final radiographic appearances of LCPD in India and BC though differences in the distribution of the classification systems warrant further study.
Factors Associated with Musculoskeletal Injuries While Hiking with a Backpack at Philmont Scout Ranch
Authors: Stoltzfus Ky B. , Arvanitakis Alex V. , Kennedy Lauren M. , McGregor Kathryn R. , Zhang Bo , Hu Jinxiang 
Published: January 2022

Introduction Participants at Philmont Scout Ranch embark on 12-d treks with pre-trek physical conditioning and medical clearance by their primary care physician. In this study, we investigated potential contributing factors to self-reported musculoskeletal injuries during a backpack trek. Methods This study was a prospective cohort study that used a 3-part survey administered to participants before, during, and after their trek from June through August 2019. Health history and demographic information were retrieved from each hiker’s medical record. A logistic regression model was used to assess factors associated with injuries, and odds ratios and 95% confidence intervals were reported. Results There were 1206 individuals enrolled in this study, and none withdrew from participation. The median age of the participants was 17 y (interquartile range 15–47); 1130 were male, 75 were female, and 1 was of unknown sex. Injuries were reported by 7% (n=88) of participants while in the backcountry, with injuries occurring in various anatomic locations (knee, ankle, leg, foot, hand, arm). Participants without missing data (74% n=897) were included in the logistical regression analysis to describe factors significantly associated with injury. Factors significantly associated with injury included greater backpack weight to body weight ratio, body mass index greater than 30 kg·m-2, and past injuries that required a doctor visit. Conclusions Self-reported injuries while hiking at Philmont Scout Ranch are infrequent and do not often require evacuation or advanced medical care. Camp policies to maintain appropriate backpack weight and counseling of obese and previously injured individuals may mitigate injury occurrence.
Structural styles and tectonic evolution of Mesozoic–Cenozoic faults in the Eastern Depression of Bayanhaote Basin, China: implications for petroleum traps
Authors: Zhou Zhicheng , Ding Wenlong , Zhang Ruifeng , Xue Mingwang , Jiao Baocheng , Wu Chenlin , Chen Yuting , Qiu Liang , Du Xiaoyu , Liu Tianshun 
Published: January 2022

AbstractThe Eastern Depression in the Bayanhaote Basin in western Inner Mongolia has experienced multi-stage Meso-Cenozoic tectonic events and possesses considerable exploration potential. However, structural deformation patterns, sequences and the genesis of oil-bearing structures in the basin are still poorly understood. In this study, based on high-quality 2D seismic data and drilling and well-logging data, we elucidate the activities and structural styles of faults, the tectonic evolution and the distribution characteristics of styles, as well as assessing potential petroleum traps in the Eastern Depression. Five types of faults that were active at different stages of the Meso-Cenozoic faults have been recognized: long-lived normal faults active since the late Middle Jurassic; reverse faults and strike-slip faults active in the late Late Jurassic; normal faults active in the Early Cretaceous; normal faults active in the Oligocene; and negative inverted faults active in the Early Cretaceous and Oligocene. These faults constituted 12 geometric styles in NE-trending belts at various stratigraphic levels, and were formed by compression, strike-slip, extension and inversion. The temporal development of structural styles promoted the formation and reconstruction and finalization of structural traps, while regional unconformities and open reverse and strike-slip faults provided migration pathways for petroleum to fill the traps. In general, potential traps that formed by compressional movement and strike-slip movement in the late Late Jurassic are primarily faulted anticlines. Those traps developed in Carboniferous rocks and are located in the southwestern region of the Eastern Depression, being controlled by NNE-NE-striking reverse and transpressive faults.
Barrier enclosure in tracheostomy: a protective box for healthcare workers during the coronavirus disease 2019 pandemic
Authors: Nair N P , Sharma V , Dixit A , Goyal S , Dixit S G , Goyal A , Misra S 
Published: January 2022

AbstractBackgroundTracheostomy, being a high aerosol-generating procedure, poses a great challenge to surgeons, especially during the coronavirus disease 2019 pandemic. It is important to preserve staff numbers as this fight may go on for a long time. Personal protective equipment plays a key role in the protection of healthcare workers. Barrier enclosure has been attempted in procedures such as intubation and tracheostomy. The use of boxes became popularised for intubation and they have been utilised in many centres.MethodsThis paper describes the box designed by our team and presents our surgical experience with the box. The box is made of transparent acrylic. It is sealed at all ends, with a negative-pressure environment. The hand ports were designed to allow maximum manoeuvrability for surgeons, without restricting hand movements.ConclusionThe proposed box will provide more protection to healthcare workers during tracheostomy. However, the box is yet to be validated.