bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting risk of severe neonatal outcomes in preterm infants born from mother with prelabor rupture of membranes
Authors: Zhuang Lu , Li Zhan-Kui , Zhu Yuan-Fang , Ju Rong , Hua Shao-Dong , Yu Chun-Zhi , Li Xing , Zhang Yan-Ping , Li Lei , Yu Yan , Zeng Wen , Cui Jie , Chen Xin-Yu , Peng Jing-Ya , Li Ting , Feng Zhi-Chun 
Published: July 2022

Abstract
Background
Perinatal complications are common burdens for neonates born from mother with pPROM. Physicians and parents sometimes need to make critical decisions about neonatal care with short- and long-term implications on infant’s health and families and it is important to predict severe neonatal outcomes with high accuracy.

Methods
The study was based on our prospective study on 1001 preterm infants born from mother with pPROM from August 1, 2017, to March 31, 2018 in three hospitals in China. Multivariable logistic regression analysis was applied to build a predicting model incorporating obstetric and neonatal characteristics available within the first day of NICU admission. We used enhanced bootstrap resampling for internal validation.

Results
One thousand one-hundred pregnancies with PROM at preterm with a single fetus were included in our study. SNO was diagnosed in 180 (17.98%) neonates. On multivariate analysis of the primary cohort, independent factors for SNO were respiratory support on the first day,, surfactant on day 1, and birth weight, which were selected into the nomogram. The model displayed good discrimination with a C-index of 0.838 (95%CI, 0.802–0.874) and good calibration performance. High C-index value of 0.835 could still be reached in the internal validation and the calibration curve showed good agreement. Decision curve analysis showed if the threshold is > 15%, using our model would achieve higher net benefit than model with birthweight as the only one predictor.

Conclusion
Variables available on the first day in NICU including respiratory support on the first day, the use of surfactant on the first day and birthweight could be used to predict the risk of SNO in infants born from mother with pPROM with good discrimination and calibration performance.
Bullying and other risk factors related to adolescent suicidal behaviours in the Philippines: a look into the 2011 GSHS Survey
Authors: Chiu Hsuan , Vargo Elisabeth Julie 
Published: July 2022

Abstract
Backgrounds
The present study retrospectively examined gender differences in bullying and suicidal behaviour (ideation, plan, and attempts) as well as associations between selected risk factors and suicidal behaviour among secondary school Filipino students.

Methods
The study used a secondary data set from the GSHS developed by the World Health Organization, which was conducted in the Philippines in 2011. Participants included 5290 Filipino students (male N = 2279, female N = 2986). A two-tailed Chi-square of independence was used to test for gender differences and a multivariate logistic regression model explored statistical associations between risk factors and outcome variables.

Results
Chi-square results suggested that gender differences were statistically significant for being bullied χ2 (1, N = 2384) = 10.6, p = .001, experiencing suicidal ideation χ2 (1, N = 857) = 61.7, p = .000, making suicide plans χ2 (1, N = 590) = 10.2, p = .001, and suicide attempts χ2 (1, N = 674) = 8.4, p = .004, with females showing higher vulnerability to examined risk factors. The logistic regression model also suggested that adolescents claiming to have no close friends were three to four times more likely to attempt suicide. Other strong predictors of suicidal behaviours were loneliness and getting in trouble due to alcohol consumption.

Conclusions
Bullying is an independent yet, not the strongest predictor associated with adolescents’ suicidal behaviour in the present study. The strongest predictors of Filipino adolescents’ suicidal behaviours in the 2011 cohort included having no close friends, loneliness, anxiety and getting in trouble due to alcohol use among both genders. Peer and mental health support programmes need to be made available and accessible for adolescents in the Philippines. Considering the increase in suicide rates in 2020/2021 among Filipino young adults due to the Coronavirus pandemic, it is suggested that preventing suicidal vulnerability in adolescence can hinder this occurrence later on in the lifetime.
Trends in avoidable hospitalizations in a developed City in eastern China: 2015 to 2018
Authors: Chen Siyuan , Fu Hongqiao , Jian Weiyan 
Published: July 2022

Abstract
Objective
This study aimed to measure the avoidable hospitalization rate and the treatment cost per hospitalization in large cities of eastern China.

Methods
In this study, the hospital discharge data of all inpatients in the city from 2015 to 2018 were collected. In accordance with the organization for Economic Cooperation and Development (OECD) definition of avoidable hospitalizations, five diseases were selected as the measurement objects, including hypertension, diabetes, asthma, chronic obstructive pulmonary disease (COPD), as well as congestive heart failure (CHF). We described the avoidable hospitalization rate, average cost and length of stay for avoidable hospitalization cases. Linear probability model and log-linear model were used to control the basic characteristics and disease severity of patients, and to measure the trend of the avoidable hospitalization rate and expenditure of avoidable hospitalizations.

Results
From 2015 to 2018, the absolute number of avoidable hospitalizations in the city increased while fluctuating, which reached 125,372 in 2018. Among the five avoidable hospitalizations, the number of hospitalizations for diabetes increased continuously in the 4-year period. Congestive heart failure showed the most significant increase over the four years. Avoidable hospitalizations in the city have remained at a high level, while avoidable hospitalizations of hypertension and asthma fell to levels lower than those in 2015 in 2017 and 2018 after rising in 2016. The cost per hospitalization and length of stay per hospitalization decreased.

Conclusions
Avoidable hospitalizations in the city remain at a high level, and more effective policies should be formulated to guide patients with avoidable hospitalizations, so as to more effectively exploit outpatient services and continuously improve the quality of primary health care services.
Refining bulk segregant analyses: ontology-mediated discovery of flowering time genes in Brassica oleracea
Authors: Vos Rutger A. , van der Veen-van Wijk Catharina A. M. , Schranz M. Eric , Vrieling Klaas , Klinkhamer Peter G. L. , Lens Frederic 
Published: July 2022

AbstractBackgroundBulk segregant analysis (BSA) can help identify quantitative trait loci (QTLs), but this may result in substantial bycatch of functionally irrelevant genes.ResultsHere we develop a Gene Ontology-mediated approach to zoom in on specific genes located inside QTLs identified by BSA as implicated in a continuous trait. We apply this to a novel experimental system: flowering time in the giant woody Jersey kale, which we phenotyped in four bulks of flowering onset. Our inferred QTLs yielded tens of thousands of candidate genes. We reduced this by two orders of magnitude by focusing on genes annotated with terms contained within relevant subgraphs of the Gene Ontology. A pathway enrichment test then led to the circadian rhythm pathway. The genes that enriched this pathway are attested from previous research as regulating flowering time. Within that pathway, the genesCCA1,FT, andTSFwere identified as having functionally significant variation compared toArabidopsis. We validated and confirmed our ontology-mediated results through genome sequencing and homology-based SNP analysis. However, our ontology-mediated approach produced additional genes of putative importance, showing that the approach aids in exploration and discovery.ConclusionsOur method is potentially applicable to the study of other complex traits and we therefore make our workflows available as open-source code and a reusable Docker container.
A novel pathogenetic factor of laryngeal attack in hereditary angioedema? Involvement of protease activated receptor 1
Authors: Farkas Henriette , Máj Csilla , Kenessey István , Sebestyén Anna , Krencz Ildikó , Pápay Judit , Cervenak László 
Published: July 2022

Abstract
Background
Hereditary angioedema (HAE) is a rare, life-threatening disease. The knowledge about the molecular pathogenesis of HAE has derived mainly from investigating blood samples. However, limited data are available on the role of the molecular mechanisms in the affected tissues during HAE attack.

Objective
The aim of our study was to explore the histological changes occurring in HAE attacks.

Methods
Post mortem macro-, microscopic and immunohistological assessment of upper airway tissues of a patient with HAE due to C1 inhibitor deficiency (C1-INH-HAE) type 2 who died from laryngeal HAE attack was compared with a non-HAE patient who died from other condition without any signs of angioedema.

Results
Compared to the control patient, we demonstrated stronger T cell/monocyte infiltration and a more intense C1-INH staining in the C1-INH-HAE patient. The expression of both bradykinin receptors (B1/B2) was observed with a slightly lower level in the C1-INH-HAE patient than in the control patient. PAR1 expression was strongly reduced in the C1-INH-HAE patient suggesting overactivation of this hyperpermeability inducing receptor.

Conclusion
Our unique case and novel results correspond to the knowledge about C1-INH and BDKRs observed in plasma; however, it revealed new information about the pathomechanism of HAE attack focusing on the potential involvement of PAR1 in edema formation. This observation, if it is verified by subcutaneous biopsy studies, may designate a new therapeutic target in HAE.
Ocean-wave phenomenon around Japan due to the 2022 Tonga eruption observed by the wide and dense ocean-bottom pressure gauge networks
Authors: Kubo Hisahiko , Kubota Tatsuya , Suzuki Wataru , Aoi Shin , Sandanbata Osamu , Chikasada Naotaka , Ueda Hideki 
Published: July 2022

AbstractOcean-bottom pressure gauges of wide and dense ocean-bottom observation networks around Japan, S-net and DONET, observed ocean waves caused by the Tonga eruption that started at approximately 13:00 JST (UTC + 0900) on January 15, 2022. We scrutinized the waveform records of the arriving ocean waves to evaluate their nature and found two significant disturbances between 20:00 and 21:00 and after 22:00. The first disturbance with a positive-polarity pulse dominated by long-period components (1000–3000 s) arrived at S-net and DONET stations between 20:00 and 21:00 from the southeast, corresponding to the direction of the short great circle between Tonga and Japan. This arrival was much earlier than expected for a direct tsunami from the volcano and can be explained by assuming that the waves propagated along the short great circle path at a velocity of approximately 300 m/s. After 22:00, significant phases dominated by relatively shorter period components (< 1000 s) arrived from the southeast direction in both observation networks. In DONET, another phase arrived from the south–southeast direction at approximately 23:30 with shorter period components (approximately 500 s). Most of the near-trench S-net stations recorded the peak amplitude during the first disturbance, whereas the near-coast S-net stations and DONET stations observed their peak after 22:00. The amplitudes of ocean-bottom pressure changes in both networks increased as the water depth decreases. This amplification behavior differed between the first and second disturbances, which is attributed to the differences in the natures of the arriving ocean and air waves. This study also found several arrivals of air-wave disturbances to be correlated with the ocean-wave phases, which implies that multiple disturbances of ocean-bottom pressures were generated by the interactions of several disturbances of air waves following the 2022 Tonga eruption with ocean waves.
Graphical abstract
Survivors’ experiences of informal social support in coping and recovering after the 2017 Manchester Arena bombing
Authors: Drury John , Stancombe John , Williams Richard , Collins Hannah , Lagan Lizzie , Barrett Alan , French Paul , Chitsabesan Prathiba 
Published: July 2022

Background
Much of the psychosocial care people receive after major incidents and disasters is informal and is provided by families, friends, peer groups and wider social networks. Terrorist attacks have increased in recent years. Therefore, there is a need to better understand and facilitate the informal social support given to survivors.

Aims
We addressed three questions. First, what is the nature of any informal support-seeking and provision for people who experienced the 2017 Manchester Arena terrorist attack? Second, who provided support, and what makes it helpful? Third, to what extent do support groups based on shared experience of the attack operate as springboards to recovery?

Method
Semi-structured interviews were carried out with a purposive sample of 18 physically non-injured survivors of the Manchester Arena bombing, registered at the NHS Manchester Resilience Hub. Interview transcripts were thematically analysed.

Results
Participants often felt constrained from sharing their feelings with friends and families, who were perceived as unable to understand their experiences. They described a variety of forms of helpful informal social support, including social validation, which was a feature of support provided by others based on shared experience. For many participants, accessing groups based on shared experience was an important factor in their coping and recovery, and was a springboard to personal growth.

Conclusions
We recommend that people who respond to survivors’ psychosocial and mental healthcare needs after emergencies and major incidents should facilitate interventions for survivors and their social networks that maximise the benefits of shared experience and social validation.
Consolidación de la innovación docente en la etapa
universitaria
Authors: Lera-Torres Javier-Isaac , Cantarero-Prieto David , Pascual-Sáez Marta 
Published: July 2022

Introducción: La crisis sanitaria generada por la COVID-19
tuvo importantes repercusiones a todos los niveles y supuso diversos
retos educativos, siendo el más relevante la suspensión de clases
presenciales. El objetivo principal de este trabajo es analizar la
implantación y futura consolidación postCOVID-19 del blended
learning. Método: Entre los nuevos métodos docentes se encuentran
las clases online, la organización de webinars impartidos por
expertos del ámbito económico y empresarial, seminarios impartidos
por los propios alumnos, el fomento de debate en foros y chats a
través de Moodle. Resultados: Algunos puntos positivos para el
alumnado son los siguientes: mejora global de los resultados, mayor
profundización en los conocimientos adquiridos, mejora de la
capacidad de debate y aprendizaje activo y cooperativo, creación de
redes de networking que permiten la colaboración entre alumnos y
agentes externos al ámbito universitario. No obstante, se detectan
desigualdades en el acceso a la tecnología y problemas de
incompatibilidad de horarios y tareas. Discusión: Los resultados
muestran una mejora de los resultados académicos y satisfacción
generalizada. Como reto fundamental queda la consolidación de estos
métodos teniendo en cuenta que en ocasiones suponen un trabajo extra
para el alumnado y la desigualdad en el acceso a la tecnología.
A Philosophy of Practising: With Deleuze’s Difference and Repetition, Antonia Pont (2021)
Authors: Hawkins Kat 
Published: July 2022

Review of: A Philosophy of Practising: With Deleuze’s Difference and Repetition, Antonia Pont (2021)
Edinburgh: Edinburgh University Press Ltd, 350 pp.,
ISBN 978-1-47449-046-7, h/bk, £80.00
Analysis of Remote Access Trojan Attack using Android Debug Bridge
Authors: Aprilliansyah Deco , Riadi Imam , Sunardi  
Published: July 2022

The security hole in the android operating system sometimes not realized by users such as malware and exploitation by third parties to remote access. This study conducted to identify the vulnerabilities of android operating system by using Ghost Framework. The vulnerability of the android smartphone are found by using the Android Debug Bridge (ADB) with the exploitation method as well as to analyze the test results and identify remote access Trojan attacks. The exploitation method with several steps from preparing the tools and connecting to the testing commands to the testing device have been conducted. The result shows that android version 9 can be remote access by entering the exploit via ADB. Some information has been obtained by third parties, enter and change the contents of the system directory can be remote access like an authorized to do any activities on the device such as opening lock screen, entering the directory system, changing the system, etc.
MENTAL DISORDER COMORBIDITY IN A PUBLIC PHYSICAL AND MENTAL HEALTH COMMUNITY-BASED CARE NETWORK SPECIALIZED IN ALCOHOL AND DRUGS
Authors: Silva Andrade Joyce Dalline , Lôbo Rossiter Pavla , Brandão Filho José Odimar de Caldas , Barbosa Filho José Pedro Martins , De Santana Danielle Cristine Almeida Silva , De Santana Fernando José Malagueño 
Published: July 2022

Mental disorder comorbidity in substance use disorder patients is a common problem with health care implications. This study aimed to investigate mental disorder comorbidity in a physical and mental health community-based care network specialized in alcohol and drug dependence. This multicenter crosssectional study included 103 substance use disorder patients from four Brazilian Referral Centers for Psycho-Social Care. Data were assessed by Mini International Neuropsychiatric Interview and Addiction Severity Index questionnaires. Unemployed single men between 30-59 years old characterized the sample and showed a significant correlation between alcohol, cocaine or crack, and cannabis dependence with some other serious mental disorders, but not among tobacco smokers. Mental disorder comorbidity is still common in some models of psychosocial care. It suggests that an unambiguous dual-diagnosis and a precise differentiation between primary mental disorders and substance use disorders must be a common clinical staff practice part of the routine in the different models of drug dependence care to obtain an effective mental health intervention for these individuals.
ANÁLISE ECONÔMICA DOS GASTOS COM MEDICAMENTOS DESCARTADOS POR HOSPITAL PÚBLICO DE TERESINA, PI, BRASIL
Authors: Santos Maria do Carmo Machado , Siqueira Sávio Moreira , Verde Roseane Mara Cardoso Lima , Baia Sheylla Jennifer de Alencar Arrais , Carvalho João Conrado de Amorim , Carneiro Sabrina Maria Portela 
Published: July 2022

A Farmácia Hospitalar é a unidade responsável pela gestão dos medicamentos, devendo atuar com eficiência econômica sobre capital aplicado, de modo a evitar o estoque e desperdício de medicamentos, como as perdas por prazo de validade expirado. O objetivo do estudo foi identificar as perdas de medicamentos por prazo de validade expirado e os custos associados em um hospital público de Teresina (PI). Foi realizado um estudo observacional retrospectivo, de modo a identificar as unidades de medicamentos descartados no período de junho de 2017 a agosto de 2018. Os dados referentes aos custos de aquisição desses medicamentos e os custos relativos ao tratamento dos resíduos foram coletados e sumarizados na forma de frequências absolutas e relativas. Nesse período 9.800 unidades de medicamentos foram inutilizadas, totalizando um custo de R$ 50.108,56. O maior grupo de medicamentos descartados, segundo a classificação ATC (Anatomical Therapeutic Chemical Classification System), pertencia ao grupo dos fármacos com ação no sistema nervoso e sistema cardiovascular. De março a maio de 2018 viu-se o maior número de medicamentos inutilizados, 3716 unidades, e o maior valor com os medicamentos descartados R$ 18.727,05. Do total de medicamentos vencidos, 5518 (56,31%) unidades foram provenientes da Central de Abastecimento Farmacêutico (CAF) e 2258 (23,04%) do Dispensário. O gasto total com o descarte de medicamentos foi de R$ 1.940,23. A soma das despesas com a aquisição e o custo para descarte foram de R$ 52.048,79. O desperdício de medicamentos na unidade hospitalar denota a importância da implantação de metodologias para o gerenciamento dos recursos com o intuito de minimizar custos, mas também com a finalidade de melhorar a qualidade do serviço de saúde. Os resultados deste estudo podem auxiliar na programação de um sistema de gestão adequada de medicamentos e na melhoria de toda a cadeia de suprimentos.
ADESÃO À FARMACOTERAPIA: DESENVOLVIMENTO DE FERRAMENTAS GRÁFICAS QUE AUXILIEM NO USO RACIONAL DO TACROLIMO TÓPICO
Authors: Villa Ana Lúcia Vazquez , Mansour Fraga Aline Guerra , Dos Santos Elisabete Pereira , Siqueira Bernardo Nascimento 
Published: July 2022

Para o controle efetivo de muitas doenças, em especial as crônicas, o componente mais importante é a adesão à farmacoterapia. Durante o atendimento farmacêutico realizado na Farmácia Universitária (FU) da Faculdade de Farmácia da Universidade Federal do Rio de Janeiro, foi constatado o retorno prematuro dos usuários do medicamento tacrolimo na forma farmacêutica pomada, constituindo-se de uma falha na correta utilização do mesmo e no provável processo de adesão à farmacoterapia. Assim, o objetivo do trabalho foi desenvolver ferramentas gráficas ilustrativas especialmente criadas para o uso do medicamento tacrolimo por pacientes atendidos na FU, com o intuito de otimizar a utilização e a consequente adesão à farmacoterapia. Como metodologia, foi realizado um levantamento bibliográfico sobre o medicamento que embasou a criação das ferramentas gráficas. No atendimento farmacêutico na FU pode-se constatar as dificuldades enfrentadas pelos pacientes quanto ao uso do medicamento. Como resultado, o desenvolvimento dos materiais gráficos, folder e cartaz embasados nas demandas apresentadas, foram eficientes na complementação da comunicação já existente no atendimento farmacêutico, contribuindo como um meio adicional para a literacia em saúde e para o uso racional do medicamento, com consequente melhora na adesão ao tratamento.