bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomics Nomogram Based on Multiple-Sequence Magnetic Resonance Imaging Predicts Long-Term Survival in Patients Diagnosed With Nasopharyngeal Carcinoma
Authors: Liu Kai , Qiu Qingtao , Qin Yonghui , Chen Ting , Zhang Diangang , Huang Li , Yin Yong , Wang Ruozheng 
Published: April 2022

PurposeAlthough the tumor–node–metastasis staging system is widely used for survival analysis of nasopharyngeal carcinoma (NPC), tumor heterogeneity limits its utility. In this study, we aimed to develop and validate a radiomics model, based on multiple-sequence magnetic resonance imaging (MRI), to estimate the probability of overall survival in patients diagnosed with NPC.MethodsMultiple-sequence MRIs, including T1-weighted, T1 contrast, and T2-weighted imaging, were collected from patients diagnosed with NPC. Radiomics features were extracted from the contoured gross tumor volume of three sequences from each patient using the least absolute shrinkage and selection operator with the Cox regression model. The optimal Rad score was determined using 12 of the 851 radiomics features derived from the multiple-sequence MRI and its discrimination power was compared in the training and validation cohorts. For better prediction performance, an optimal nomogram (radiomics nomogram-MS) that incorporated the optimal Rad score and clinical risk factors was developed, and a calibration curve and a decision curve were used to further evaluate the optimized discrimination power.ResultsA total of 504 patients diagnosed with NPC were included in this study. The optimal Rad score was significantly correlated with overall survival in both the training [C-index: 0.731, 95% confidence interval (CI): 0.709–0.753] and validation cohorts (C-index: 0.807, 95% CI: 0.782–0.832). Compared with the nomogram developed with only single-sequence MRI, the radiomics nomogram-MS had a higher discrimination power in both the training (C-index: 0.827, 95% CI: 0.809–0.845) and validation cohorts (C-index: 0.836, 95% CI: 0.815–0.857). Analysis of the calibration and decision curves confirmed the effectiveness and utility of the optimal radiomics nomogram-MS.ConclusionsThe radiomics nomogram model that incorporates multiple-sequence MRI and clinical factors may be a useful tool for the early assessment of the long-term prognosis of patients diagnosed with NPC.
Chemotherapy Combined With Surgery in a Case With Metanephric Adenoma
Authors: Hu Shaohua , Zhao Zhenli , Wan Zhisheng , Bu Weizhen , Chen Songqiang , Lu Yiqun 
Published: April 2022

BackgroundMetanephric adenoma is an extremely rare renal neoplasm, especially in pediatrics. Chemotherapy combined with surgery in metanephric adenoma has not been reported.MethodsWe describe a case of metanephric adenoma in a child less than 2 years old, which were treated by chemotherapy combined with surgery.ResultsNephron sparing surgery was performed after regular chemotherapy, and the pathological result was metanephric adenoma.ConclusionPediatric metanephric adenoma is extremely rare; the clinical manifestations and imaging examinations lack specificity. Nephron sparing surgery is recommended as the preferred treatment for metanephric adenoma. Long-term follow-up and more in-depth molecular genetic research are still needed to determine the benign or malignant of metanephric adenoma and whether chemotherapy drugs have an effect on it.
Thymoquinone’s Antiviral Effects: It is Time to be Proven in the Covid-19 Pandemic Era and its Omicron Variant Surge
Authors: Abdelrahim Maen , Esmail Abdullah , Al Saadi Noor , Zsigmond Eva , Al Najjar Ebtesam , Bugazia Doaa , Al-Rawi Hadeel , Alsaadi Ayat , Kaseb Ahmed O. 
Published: April 2022

The COVID-19 pandemic has impacted every country in the world. With more than 400 million cases and more than 5.5 million deaths. The FDA either approved or authorized the emergency use for three vaccines against COVID-19. The treatment options of COVID-19 are very limited. Multiple complementary and alternative medicine modalities were suggested to be efficacious in the treatment of COVID-19 such as Thymoquinone. The effects of Thymoquinone have been examined and multiple studies indicate a promising beneficial effect. However, the current body of research is limited in terms of its scope, quality, and quantity. While higher-quality studies are required, physicians do not routinely recommend the use of marketed supplements of natural products, including Thymoquinone for COVID-19. Given the numerous suggested positive effects of Thymoquinone, including anti-inflammatory and antimicrobial properties, additional research is required to confirm or refute these promising benefits. Complementary and alternative medicine is an area that requires additional evidence-based practice and research to confirm effects observed in clinical practice.
Metformin Use on Incidence and Oncologic Outcomes of Bladder Cancer Patients With T2DM: An Updated Meta-Analysis
Authors: Liu Chen-Qian , Sun Jian-Xuan , Xu Jin-Zhou , Qian Xiao-Yuan , Hong Sen-Yuan , Xu Meng-Yao , An Ye , Xia Qi-Dong , Hu Jia , Wang Shao-Gang 
Published: April 2022

Background: The incidence rate and mortality of bladder cancer are increasing year by year. Interestingly, the commonly used metabolic regulatory drug metformin has been reported to have anti-tumor effect in recent years. Nevertheless, it keeps unclear whether the usage of metformin is beneficial or unbeneficial in treating bladder cancer. Thus, a meta-analysis was conducted to explore the long-term effect of metformin on the incidence of bladder cancer and OS, PFS, DSS and RFS in bladder cancer patients with T2DM.Method: We aim to collect evidence of the association between the usage of metformin and the incidence and treatment outcome of bladder cancer. We searched PubMed, Embase, Ovid Medline and Cochrane Library up to February 2021 to get effective literature reporting the effects of metformin in bladder cancer. The main outcomes were the protective effects of metformin on the incidence, overall survival (OS), recurrence-free survival (RFS), progression-free survival (PFS), and disease-specific survival (DSS) of bladder cancer. And OR (odds ratio) and HR (hazard ratio) with their 95%CI were pooled. Two independent researchers assessed the quality of included studies using the Newcastle-Ottawa Scale (NOS).Results: We involved 12 studies meeting the inclusion criteria, including a total of 1,552,773 patients. The meta-analysis showed that use of metformin could decrease the incidence (OR = 0.45, 95%CI = 0.37–0.56; p &lt; 0.01) and prolong recurrence-free-survival (HR = 0.56, 95%CI = 0.41–0.76; p = 0.91) of bladder cancer. However, there were no significant protective effects in the overall survival (HR = 0.93, 95%CI = 0.67–1.28, p = 0.05), disease-specific-survival (HR = 0.73, 95%CI = 0.47–1.16; p = 0.01), and progression-free-survival (HR = 0.78, 95%CI = 0.53–1.15, p = 0.34).Conclusion: The results revealed that the usage of metformin could reduce the incidence of bladder cancer and prolong the prognosis of bladder cancer in T2DM patients, respectively. More prospective studies are needed to prove the protective role of metformin on bladder cancer.
Physical Activity in Late Prepuberty and Early Puberty Is Associated With High Bone Formation and Low Bone Resorption
Authors: Rempe Jakob , Rosengren Björn E. , Jehpsson Lars , Swärd Per , Dencker Magnus , Karlsson Magnus K. 
Published: April 2022

BackgroundPhysical activity (PA) increases bone mass, especially in late prepuberty and early puberty, but it remains unclear if and how PA affects both bone formation and bone resorption.Materials and MethodsWe included 191 boys and 158 girls aged 7.7 ± 0.6 (mean ± SD) in a population-based PA intervention study. The intervention group (123 boys and 94 girls) received daily physical education (PE) in school (40 min/day; 200 min/week) from study start and during the nine compulsory school years in Sweden. The controls (68 boys and 64 girls) received the national standard of 1–2 classes PE/week (60 min/week). During the intervention, blood samples were collected at ages 9.9 ± 0.6 (n = 172; all in Tanner stages 1–2) and 14.8 ± 0.8 (n = 146; all in Tanner stages 3–5) and after termination of the intervention at age 18.8 ± 0.3 (n = 93; all in Tanner stage 5) and 23.5 ± 0.7 (n = 152). In serum, we analyzed bone formation markers [bone-specific alkaline phosphatase (bALP), osteocalcin (OC), and N-terminal propeptide of collagen type 1 (PINP)] and bone resorption markers [C-terminal telopeptide cross links (CTX) and tartrate-resistant acid phosphatase (TRAcP 5b)]. Linear regression was used to compare age and sex-adjusted mean differences between intervention children and controls in these markers.ResultsTwo years after the intervention was initiated (at Tanner stages 1–2), we found higher serum levels of bALP and OC, and lower serum levels of TRAcP 5b in the intervention compared with the control group. The mean difference (95% CI) was for bALP: 13.7 (2.1, 25.3) μg/L, OC: 9.1 (0.1, 18.1) μg/L, and TRAcP 5b: −2.3 (−3.9, −0.7) U/L. At Tanner stages 3–5 and after the intervention was terminated, bone turnover markers were similar in the intervention and the control children.ConclusionDaily school PA in the late prepubertal and early pubertal periods is associated with higher bone formation and lower bone resorption than school PA 1–2 times/week. In late pubertal and postpubertal periods, bone formation and resorption were similar. Termination of the intervention is not associated with adverse bone turnover, indicating that PA-induced bone mass benefits gained during growth may remain in adulthood.
Expression of CCL2, FOS, and JUN May Help to Distinguish Patients With IgA Nephropathy From Healthy Controls
Authors: Zhou Xue , Wang Ning , Zhang Yuefeng , Yu Pei 
Published: April 2022

BackgroundIgA nephropathy (IgAN), the most common type of glomerulonephritis worldwide, can only be diagnosed mainly by renal biopsy owing to lack of effective biomarkers. It is urgent to explore and identify the potential diagnostic biomarkers through assessing the gene expression profiles of patients with IgAN.MethodsTwo datasets were obtained from the Gene Expression Omnibus (GEO) database, including GSE115857 (55 IgAN, 7 living healthy donors) and GSE35487 (25 IgAN, 6 living healthy donors), then underwent differentially expressed genes (DEGs) and function enrichment analyses utilizing R packages. The common gene list was screened out between DEGs and immune-associated genes by Venn diagram, then performed gene-gene interaction, protein-protein interaction (PPI) and function enrichment analyses. Top three immune-associated hub genes were selected by Maximal Clique Centrality (MCC) method, then the expression and diagnostic value of these hub genes were determined. Consensus clustering algorithm was applied to conduct the unsupervised cluster analysis of the immune-associated hub gene list in IgAN. Finally, the Nephroseq V5 tool was applied to identify the expression level of CCL2, FOS, JUN in kidney diseases, as well as the correlation between CCL2, FOS, JUN expression and renal function in the patients with IgAN.ResultsA total of 129 DEGs were obtained through comparing IgAN with healthy controls via the GSE115857 and GSE35487 datasets. Then, we screened out 24 immune-associated IgAN DEGs. CCL2, JUN, and FOS were identified as the top three hub genes, and they were all remarkably downregulated in IgAN. More importantly, CCL2, JUN, and FOS had a high accuracy [area under the curve (AUC) reached almost 1] in predicting IgAN, which could easily distinguish between IgAN patients and healthy individuals. Three distinct subgroups of IgAN were determined based on 24 immune-associated DEGs, with significant differences in the expression of CCL2, JUN, and FOS genes. Finally, CCL2, FOS, JUN were manifested a meaningful association with proteinuria, glomerular filtration rate (GFR), and serum creatinine level.ConclusionIn summary, our study comprehensively uncovers that CCL2, JUN, and FOS may function as promising biomarkers for diagnosis of IgAN.
A Super-Microsurgery Training Model: The Mouse Caudal Artery Anastomosis Model
Authors: Wu Xue-Qiang , Liu Hui-Ren , Yu Zhan-Yong , Wang Yan , Sun Ru-Tao , Wang Li , Gao Yuan 
Published: April 2022

ObjectiveTo establish a simple and practical model for super-microsurgery training using the middle caudal arteries of Kunming mice.MethodsA ⊔-shaped incision was made approximately 1 cm from the root of the tail in the mouse, and the skin, together with the subcutaneous tissue, was turned up into a rectangular shape to the opposite side with exposure of the mouse middle caudal artery and the accompanying veins. The artery was freed for approximately 1 cm in length. The middle caudal artery was cut transversely at the site, and then the severed middle caudal artery was anastomosed end-to-end using 12-0 microsutures in the order of 6, 12, 3, and 9 o'clock with four stitches.ResultsThe mouse caudal artery had a constant anatomical location accompanied by a vein. The immediate postoperative patency after vascular anastomosis was 100% (15/15) in all mouse models, the postoperative patency was 100% (5/5), 80% (4/5), and 75% (3/4) at 24 h, 3 days, and 1 week postoperatively, respectively. The outer diameter of the mouse middle caudal artery was 0.2 ~ 0.3 (0.22 ± 0.03) mm. The vascular anastomosis time was 6.5 ~ 15 (11.0 ± 2.5) min.ConclusionThe mouse middle caudal artery was superficially located and anatomically constant, making it easy to be located and exposed. The small size of the opening made it suitable for establishing a useful model for training in super-microsurgery vascular anastomoses.
Auditoria financiera y presentación razonable de estados financieros en gobiernos locales de Lima Metropolitana
Authors: Donayre Reyes Yvonne Carolina 
Published: April 2022

La auditoría financiera al interior de los gobiernos locales se muestra como un proceso que ignora las normas internacionales y nacionales, además de realizarse sin legalidad y formalidad correspondiente; en ese sentido la investigacióndilucidólaimportancia de la auditoria financiera y la presentación razonable de los estados financieros en Gobiernos Locales de Lima Metropolitana, así como los elementos necesarios para su elaboración. Por ello la indagación siguió la metodología descriptiva de corte transversal, empleando métodos mixtos, donde la población está conformada por 57 funcionario. Además, para el análisis se empleará la técnica de la encuesta y el instrumento del cuestionario, utilizando el sistema SPSS y la correlación Spearman. Finalmente, la correlación es 90.33% como el grado de significancia es igual al 3.39%, con lo cual se concluye que la auditoría financiera incide favorablemente en la presentación razonable de los estados financieros en los Gobiernos Locales de Lima Metropolitana.
Gestión moderna para una administración efectiva
Authors: Manchay Calvay Angel 
Published: April 2022

La administración efectiva permite la transformación de la estrategia, los procesos, la tecnología y las personas para reorientar la organización al logro de sus objetivos, maximizar su desempeño y asegurar el mejoramiento continuo; sin embargo; la administración efectiva del Hospital Regional Lambayeque, Perú, el recurso humano trabaja en un clima organizacional hostil, desmotivado, y una insatisfacción personal; para ello el propósito de este estudio fue identificar los procesos y funcionamiento de la gestión moderna en el sistema hospitalario que fortalece a la administración efectiva en el Hospital Regional Lambayeque. Para ello se utilizó un enfoque de carácter cuantitativo, de tipo descriptivo con un diseño transversal no experimental; asimismo se usó una muestra con un muestreo no probabilístico con una unidad de análisis de 46 responsables y/o jefes de áreas administrativas y asistenciales; se utiliza la técnica de la encuesta a través de un instrumento del cuestionario que fueron los mecanismos de medición aplicados en el presente trabajo. Obteniendo un resultado del 47.83% de trabajadores del Hospital Regional de Lambayeque percibe la existencia de una gestión moderna regular y buena. En la cual se concluye que se debe implementar el modelo de gestión moderna para obtener una administración efectiva, que conlleve a cumplir las metas y objetivos institucionales, permitiendo cerrar brechas mediante la modernización de la gestión pública.
Aplicación de la técnica manual craneosacral en mujeres que laboran en la Educación Superior
Authors: Barzola García Karen , Mera Morán Gary Andrés , Jurado Auria Stalin Augusto , Hernández Villacrés Ivanna Laleska , Burbano Lajones Abigail Elena , Villacrés Caicedo Sheyla Elizabeth 
Published: April 2022

En la actualidad la mayoría de las personas por lo menos una vez en el año presenta una molestia en la estructura del cuello, considerado como cervicalgia o dolor cervical, el mismo que está ocasionando un impacto considerable en la vida de las personas dentro del ámbito familiar, laboral y en la comunidad, provocando efectos negativos en la calidad de vida y en casos severos puede llegar a ocasionar discapacidad y limitación funcional de los movimientos. Por lo que este estudio presentó como objetivo determinar la efectividad de la aplicación de la técnica manual craneosacral en mujeres que laboran en la Universidad Católica de Santiago de Guayaquil. La metodología que se utilizó fue un enfoque cuantitativo- descriptivo con un diseño experimental del tipo pre experimental, con un corte longitudinal, se utilizó como muestra a 31 mujeres que laboran en diversas áreas de la Universidad Católica Santiago de Guayaquil, a su vez, se utilizó como técnica la encuesta, y el instrumento aplicado para la valoración del dolor cervical fue la escala visual analógica del dolor (EVA). Los resultados de esta técnica respecto a la escala visual analógica (EVA) mediante una valoración inicial y final, reflejaron mejoría en el dolor cervical donde el 68% de las pacientes no presentaron dolor, y el 32% reflejan un dolor leve. Se concluyó, que por medio de la técnica manual craneosacral el dolor disminuyo en un gran porcentaje restableciendo los procesos naturales del equilibrio del cuerpo a través de la terapia manual.
ANALISIS MATERI NAHWU DALAM KITAB AUDLOHUL MANAHIJ FI MU’JAM QOWA’IDUL LUGHOH AL ‘AROBIYAH
Authors: Suharsono Suharsono , Zakawali M. Akzomi 
Published: April 2022

This article is aim to analyze the appropriated of Nahwu Book to educated someone who want to learn arabic language easily. This book created by Agus Shohib Khoironi, Lc in 2001 by using Mustaqilli method for the teaching arabic language. In analizing this book, this research is a library research then analyzing by nahwu material analysis, in the other side, this research also analyzing with conducting four principles of William F. Mackey’s theory which includes: repetition, presentation, gradation, and selection. From the results of the analysis of the nahwu material in the book Audhohul Manahij Fi Mu'jam Qowaidul Lughoh Al-Arabiyah, it was found that the preparation of this book was in accordance with Mackey's theory of gradation, selection, presentation and repetition. The nahwu material is arranged in a coherent way from a discussion of the basic nahwu qoidah to more depth, starting with the kalam chapter to the Jama 'Taksir chapter in the first part of this book, which consists of 14 discussion chapters.
Active Learning Module for Protein Structure Analysis Using Novel Enzymes
Authors: Kelz Jessica I. , Takahashi Gemma R. , Safizadeh Fatemeh , Farahmand Vesta , Crosby Marquise G. , Uribe Jose L. , Kim Suhn H. , Sprague-Piercy Marc A. , Diessner Elizabeth M. , Norton-Baker Brenna , Damo Steven M. , Martin Rachel W. , Kadandale Pavan 
Published: April 2022

ABSTRACT
A major challenge for science educators is teaching foundational concepts while introducing their students to current research. Here we describe an active learning module developed to teach protein structure fundamentals while supporting ongoing research in enzyme discovery. It can be readily implemented in both entry-level and upper-division college biochemistry or biophysics courses. Preactivity lectures introduced fundamentals of protein secondary structure and provided context for the research projects, and a homework assignment familiarized students with 3-dimensional visualization of biomolecules with UCSF Chimera, a free protein structure viewer. The activity is an online survey in which students compare structure elements in papain, a well-characterized cysteine protease from Carica papaya, to novel homologous proteases identified from the genomes of an extremophilic microbe (Halanaerobium praevalens) and 2 carnivorous plants (Drosera capensis and Cephalotus follicularis). Students were then able to identify, with varying levels of accuracy, a number of structural features in cysteine proteases that could expedite the identification of novel or biochemically interesting cysteine proteases for experimental validation in a university laboratory. Student responses to a postactivity survey were largely positive and constructive, describing points in the activity that could be improved and indicating that the activity was an engaging way to learn about protein structure.
Point-defect management in homoepitaxially grown Si-doped GaN by MOCVD for vertical power devices
Authors: Rathkanthiwar Shashwat , Bagheri Pegah , Khachariya Dolar , Mita Seiji , Pavlidis Spyridon , Reddy Pramod , Kirste Ronny , Tweedie James , Sitar Zlatko , Collazo Ramón 
Published: April 2022

Abstract
We demonstrate controlled Si doping in the low doping range of 5 × 1015–2.5 × 1016 cm−3 with mobility >1000 cm2 V−1 s−1 in GaN films grown by metalorganic chemical vapor deposition. The carbon-related compensation and mobility collapse were prevented by controlling the electrochemical potential near the growth surface via chemical potential control (CPC) and defect quasi-Fermi level (dQFL) point-defect management techniques. While the CPC was targeted to reduce the net CN concentration, the dQFL control was used to reduce the fraction of C atoms with the compensating configuration, i.e.

C

N

−
1

.

The low compensating acceptor concentration was confirmed via temperature-dependent Hall effect analysis and capacitance–voltage measurements.
Manejabilidad del concreto convencional mediante implementación de agregados alternativos
Authors: Cárdenas Gutiérrez JA , Jácome Carrascal José Leonardo , Vergel Ortega Mawency 
Published: April 2022

La manejabilidad del concreto es una característica de suprema importancia para la elaboración de estructuras esbeltas y exigentes que demanda la sociedad actual, por lo tanto, es indispensable que se reciclen o desarrollen nuevos materiales dentro de la industria de la construcción que tengan bajo impacto medio ambiental, pero que a su vez cumplan con cada una de las propiedades mínimas que debe tener el concreto como piedra artificial.
En esta investigación se realizaron diferentes dosificaciones de material reciclado de la industria cerámica con el fin de determinar el nivel de asentamiento del concreto con agregado reciclado respecto al concreto convencional.