bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology
Authors: Tamborero David , Dienstmann Rodrigo , Rachid Maan Haj , Boekel Jorrit , Lopez-Fernandez Adria , Jonsson Markus , Razzak Ali , Braña Irene , De Petris Luigi , Yachnin Jeffrey , Baird Richard D. , Loriot Yohann , Massard Christophe , Martin-Romano Patricia , Opdam Frans , Schlenk Richard F. , Vernieri Claudio , Masucci Michele , Villalobos Xenia , Chavarria Elena ,   Cancer Core Europe consortium, Anand Shubha , Baars Danny , Bajalica-Lagercrantz Svetlana , Baird Richard , Bierkens Mariska , Blomqvist Lennart , Bono Costanza , De Petris Luigi , Doherty Gary J. , Forest Arnauld , Fornerone Valentina , Gabaldi Paola , Haglund Felix , Hartman Johan , Horak Peter , Jutzi Tanja , Kasanicki Mary , Kreutzfeldt Simon , Le Cornet Lucian , Lewensohn Rolf , Lindberg Johan , Lopez Carlos , Lundqvist Andreas , Martin Jose-Ezequiel , Meijer Gerrit , Muñoz Susana , Camus Maud Ngo , Nicotra Claudio , Nuciforo Paolo , Oberrauch Petra , Östling Päivi , Pelz Laura , Piris-Gimenez Alejandro , Provenzano Elena , Rouleau Etienne , Rowell John , Saavedra Omar , Scoazec Giovanni , Seamon Kenneth , Tischkowitz Marc , van der Kolk Lizet , van der Noll Ruud , Vieito Maria , Vis Daniel , Vivancos Ana , von Gertten Christina , Wennborg Anders , Wessels Lodewyk , Wirta Valtteri , Balmaña Judith , Apolone Giovanni , Caldas Carlos , Bergh Jonas , Ernberg Ingemar , Fröhling Stefan , Garralda Elena , Karlsson Claes , Tabernero Josep , Voest Emile , Rodon Jordi , Lehtiö Janne 
Published: February 2022

AbstractThere is a growing need for systems that efficiently support the work of medical teams at the precision-oncology point of care. Here, we present the implementation of the Molecular Tumor Board Portal (MTBP), an academic clinical decision support system developed under the umbrella of Cancer Core Europe that creates a unified legal, scientific and technological platform to share and harness next-generation sequencing data. Automating the interpretation and reporting of sequencing results decrease the need for time-consuming manual procedures that are prone to errors. The adoption of an expert-agreed process to systematically link tumor molecular profiles with clinical actions promotes consistent decision-making and structured data capture across the connected centers. The use of information-rich patient reports with interactive content facilitates collaborative discussion of complex cases during virtual molecular tumor board meetings. Overall, streamlined digital systems like the MTBP are crucial to better address the challenges brought by precision oncology and accelerate the use of emerging biomarkers.
Ultrasensitive ratiometric fluorescent probes for Hg(ii) and trypsin activity based on carbon dots and metalloporphyrin via a target recycling amplification strategy
Authors: Huang Shan , Yao Jiandong , Ning Gan , Li Bo , Mu Pingping , Xiao Qi 
Published: February 2022

A ultrasensitive ratiometric fluorescent probe was developed for Hg(ii) and trypsin based on CDs and TPPS via a target recycling amplification strategy. The detection limits of Hg2+ and trypsin were 0.086 nM and 0.013 ng mL−1.
Systematic Review of Discourse and Social Communication Interventions in Traumatic Brain Injury
Authors: Lê Karen , Coelho Carl , Fiszdon Joanna 
Published: February 2022

Purpose:
This study reviewed the current state of discourse and social communication interventions in traumatic brain injury (TBI) to provide clinically focused guidance about treatment efficacy, treatment approaches by TBI severity, treatment components, and treatment outcome measures.

Method:
Searches were conducted in five electronic databases and reference lists of topical articles for discourse or social communication interventions in TBI published between 2012 and 2021. Search terms reflected three concepts: TBI, treatment, and cognitive-communication. Studies were evaluated for methodological quality using rating scales specific to study design.

Results:
Seven hundred sixty-seven records were identified, culminating in 21 studies for qualitative synthesis. All approaches resulted in improvement posttreatment, but durability and strength of evidence varied. Five treatment components were identified as “essential” for fostering change. Discourse approaches were generally more effective in mild-to-moderate TBI, whereas social communication approaches were more effective in moderate-to-severe TBI. Communication outcome measures were generally more sensitive to change than measures of other domains of functioning.

Conclusions:
The evidence suggests that discourse and social communication treatments are promising for improving communication in TBI. Selection of treatment components and tailoring treatment to the individual are important clinical considerations. Use of at least two proximal outcome measures that evaluate the target behavior and extent of functional generalization may be advantageous. The field would benefit from additional, more rigorous treatment studies to provide a greater understanding of how best to treat cognitive-communicative impairments in people with TBI.

Supplemental Material:

https://doi.org/10.23641/asha.19233516
Feeling Thrown for a Loop? The Effects of Inferencing on Spoken Language Idiom Comprehension in Autism
Authors: Martelle Stefanie N. , Namazi Mahchid 
Published: February 2022

Purpose:
The aim of this review is to illuminate the connection between inferential skills and spoken language idiom comprehension (SLIC) with a focus on autism. Idioms are frequently occurring figurative expressions, such as feeling blue, on cloud nine, and all tied up, that have literal and nonliteral meanings.

Method:
In this review article, an overview of SLIC is provided, highlighting the importance of inferential skills and other pertinent factors and theories contributing to idiom acquisition in autistic children. The search criteria used included peer-reviewed journal articles from 1982 to 2021 to synthesize both seminal and current research on this topic. Though some articles selected for this review did not focus on idioms in spoken language, they were deemed necessary for analyzing various aspects impacting idiom development and comprehension.

Results:
Research shows that figurative language differences are a hallmark feature of autism, causing idioms to be interpreted literally. Occurring in everyday spoken and written language, idiom comprehension is essential for adequate communication in daily interactions. Poor inferential abilities directly impact SLIC and have negative implications on social and academic outcomes. Several factors contributing to SLIC have been highlighted in the literature, including transparency (semantic analyzability), familiarity, and context.

Conclusions:
The comparable skills underpinning inferential comprehension and SLIC raise the argument that SLIC is incumbent upon intact inferential abilities. As such, autistic children will benefit from utilizing inference from context to deduce idiomatic meanings. Future directions for research and recommendations for improving SLIC in clinical practice are offered.
Carbon emission flow oriented multitasking multi‐objective optimization of electricity‐hydrogen integrated energy system
Authors: Wei Xiang , Sun Yuxin , Zhou Bin , Zhang Xian , Wang Guibin , Qiu Jing 
Published: February 2022

AbstractA grid‐connected electricity‐hydrogen integrated energy system (EH‐IES) is proposed here for the cooperative analysis of electricity, heat, cooling and hydrogen energy flows, where carbon emission flow (CEF) is introduced to allocate the carbon emission. Simultaneously, an improvement multitasking multi‐objective optimization (MT‐MOO) algorithm is applied to optimize the operation of this EH‐IES. The proposed EH‐IES optimizes the operational cost, carbon dioxide emission and energy loss while considering the uncertainties of future energy demand, wind and photovoltaic (PV) power outputs. The CEF model is introduced here to allocate the carbon emission among the EH‐IES, which can calculate the carbon emission in the energy flow. In order to solve the MOO model, a MT‐MOO algorithm is proposed to utilize the implicit information of different optimization tasks. However, there are harmful interactions between the different optimization tasks when the relativity between different optimization tasks is low. Therefore, the paper introduces an online learning random mating probability method which calculates the transformation extent of implicit information online between different optimization tasks. Simulation results show that the proposed EH‐IES has good feasibility and efficiency, and the proposed algorithm has better convergence performance than comparing intelligence algorithms.
« Et si tu n’existais pas… »
Authors: Bertin Claire 
Published: February 2022

« Et si tu n’existais pas… » ont été des mots-sons lancés en l’air par Yanis à la sortie du groupe thérapeutique auquel il participe deux fois par semaine. Lui qui s’exprime inlassablement par « bouillie » verbale ou mot-chose à l’intérieur duquel rien n’est animé, trié ou différencié ; aujourd’hui, il semble venir nous signifier un vécu, nous raconter peut-être ce qu’il vit ? Est-il enfin en train de « prendre vie » ? Prendre forme, prendre une densité ou un volume, entrer dans une pulsation ou encore prendre une place ? Et s’il s’agissait tout d’abord de se sentir, de s’éprouver, de se percevoir: percer et voir. « Percer » à l’image d’une traversée du miroir et passer d’un état à un autre, d’un monde à un autre; pour « voir » au sens d’incorporer, de rencontrer, de se confronter, de reconnaître sa propre présence au monde ainsi que celle de l’autre.
Tel a été l’enjeu de notre rencontre avec Yanis, petit garçon de 5 ans dont l’existence se joue entre un tout et son éclatement, où le mot est autant excitant qu’inexistant, où le contact corporel apaise autant qu’il angoisse, où l’autre intruse et détruit comme il contient. Quels facteurs ont amené Yanis à construire une première sensation de lui-même ? Quel parcours l’enfant traverse pour naître à soi-même ? Comment un travail psychocorporel peut nous acheminer et nous faire accéder à la propre perception de soi : vers une appropriation de soi…
NAL-NL1 Procedure for Fitting Nonlinear Hearing Aids: Characteristics and Comparisons with Other Procedures
Authors: Byrne Denis , Dillon Harvey , Ching Teresa , Katsch Richard , Keidser Gitte 
Published: February 2022

AbstractA new procedure for fitting nonlinear hearing aids (National Acoustic Laboratories' nonlinear fitting procedure, version 1 [NAL-NL1]) is described. The rationale is to maximize speech intelligibility while constraining loudness to be normal or less. Speech intelligibility is predicted by the Speech Intelligibility Index (SII), which has been modified to account for the reduction in performance associated with increasing degrees of hearing loss, especially at high frequencies. Prescriptions are compared for the NAL-NL1, desired sensation level [input/output], FIG6, and a threshold version of the Independent Hearing Aid Fitting Forum procedures. For an average speech input level, the NAL-NL1 prescriptions are very similar to those of the well-established NAL-Revised, Profound procedure. Compared with the other procedures, NAL-NL1 prescribes less low-frequency gain for flat and upward sloping audiograms. It prescribes less high-frequency gain for steeply sloping high-frequency hearing losses. NAL-NL1 tends to prescribe less compression than the other procedures. All procedures differ considerably from one another for some audiograms.
Abbreviations: Al = Articulation Index, CR = compression ratio, CT = compression threshold; DSL[i/o] = desired sensation level [input/output], IHAFF = Independent Hearing Aid Fitting Forum, LGOB = loudness growth in 1/2-octave bands, NAL-NL1 = National Acoustic Laboratories' nonlinear fitting procedure, version 1, NAL-R = NAL Revised, NAL-RP = NAL-Revised, Profound, PLL = preferred listening level, POGO = prescription of gain and maximum output, RAB = Ricketts and Bentler, rms = root mean square, SII = Speech Intelligibility Index, WDRC = wide dynamic range compression
Complex Procedures in Transanal Endoscopic Microsurgery: Intraperitoneal Entry, Ultra Large Rectal Tumors, High Lesions, and Resection in the Anal Canal
Authors: Serra-Aracil Xavier , Lucas-Guerrero Victoria , Mora-López Laura 
Published: February 2022

AbstractTransanal endoscopic microsurgery (TEM) allows the local excision of rectal tumors and achieves lower morbidity and mortality rates than total mesorectal excision. TEM can treat lesions up to 18 to 20 cm from the anal verge, obtaining good oncological results in T1 stage cancers and preserving sphincter function. TEM is technically demanding. Large lesions (>5 cm), those with high risk of perforation into the peritoneal cavity, those in the upper rectum or the rectosigmoid junction, and those in the anal canal are specially challenging. Primary suture after peritoneal perforation during TEM is safe and it does not necessarily require the creation of a protective stoma. We recommend closing the wall defect in all cases to avoid the risk of inadvertent perforation. It is important to identify these complex lesions promptly to transfer them to reference centers. This article summarizes complex procedures in TEM.
Transanal Local Excision or Endoscopic Dissection for Benign and Large Lesions of the Rectum
Authors: Morino Mario , Arezzo Alberto 
Published: February 2022

AbstractSince the introduction of transanal endoscopic microsurgery, local excision of “early” rectal lesions has offered the possibility to reduce the invasiveness of treatment for the limited disease. Flexible endoscopy techniques allow today different alternatives consisting of endoscopic mucosal resection or endoscopic submucosal dissection. The first is a straightforward and relatively easy technique, but it prevents a correct pathological staging of the lesion due to fragmentation and the verification of disease-free margins. The second relies on operators' audacity depending on their increasing experience due to the limited progress in technology. What is the preferable technique today is questionable. All the methods have pros and cons. The future certainly will see the use of ideal systems, allowing the possibility of precision surgery for partial- or full-thickness excision, depending on intraoperative findings, and the extension above the rectosigmoid junction. Miniaturized flexible robotic devices may represent the solution for both issues.
Technology, Expectations, and Adjustment to Hearing Loss: Predictors of Hearing Aid Outcome
Authors: Jerram J. Christopher K. , Purdy Suzanne C. 
Published: February 2022

AbstractThis study examined the influence of technology, demographic factors, and prefitting expectations, attitudes, and adjustment to hearing loss on hearing aid outcome. Clients obtaining new hearing aids completed questionnaires measuring personal adjustment to hearing loss, expectations of and attitudes toward hearing aids, and hearing aid benefit. Eighty-one percent of the 200 subjects completing the prefitting questionnaires returned questionnaires evaluating hearing aid outcome. Factors affecting hearing aid use, overall satisfaction, and benefit were investigated using regression analyses. Higher use time was associated with higher prefitting expectations and greater acceptance of hearing loss. Greater benefit in easy and difficult listening situations was predicted by higher prefitting expectations. Multiplememory hearing aids produced higher satisfaction. Benefit was greater for multiple-memory, multiple-channel, and wide dynamic range compression aids. Findings were consistent with previous studies showing positive outcomes for newer technologies but also showed that two subjective factors, prefitting hearing aid expectations and acceptance of hearing loss, significantly influenced hearing aid outcome.
Abbreviations: APHAB = Abbreviated Profile of Hearing Aid Benefit, BTE = behind the ear, CIC = completely in the canal, CPHI = Communication Profile for the Hearing Impaired, HAPI = Hearing Aid Performance Inventory, HARQ = Hearing Attitudes in Rehabilitation Questionnaire, HHIE = Hearing Handicap Inventory for the Elderly, HPI = Hearing Performance Inventory, ITC = in the canal, ITE = in the ear, MAPHAB = Modified Abbreviated Profile of Hearing Aid Benefit, MELLI = multiple environmental listening utility, MPAS = Modified Personal Adjustment Scale, PHAB = Profile of Hearing Aid Benefit, SADL = Satisfaction with Amplification in Daily Living, WDRC = wide dynamic range compression
Aging and Contralateral Suppression Effects on Transient Evoked Otoacoustic Emissions
Authors: Parthasarathy Teralandur K. 
Published: February 2022

AbstractTransient evoked otoacoustic emissions (TEOAEs) were recorded in 30 normal-hearing subjects to nonlinear clicks while continuous contralateral broadband noise (CBBN) was presented at 40, 50, 60, and 70 dB HL. Thirty subjects between 20 and 79 years were divided systematically into six-decade age groups, five subjects per group. All subjects in each group had hearing thresholds of 20 dB HL or better for the test frequencies from 0.25 to 8.0 kHz and normal acoustic immittance findings. The results provide evidence that contralateral suppression at varying levels of CBBN is interactive with age. Except for subjects in the age ranges between 60 and 69 and 70 and 79 years of age, an increase in CBBN from 40 to 70 dB in 10–dB steps resulted in an average increase in suppression from about 0.5 to 3.5 dB SPL. In addition, the contralateral suppression at 60 and 70 dB HL was significantly greater for subjects between 20 and 59 years of age than for subjects between 60 and 79 years of age.
Abbreviations: ANOVA = analysis of variance, CAP = compound action potential, CBBN = contralateral broadband noise, CNS = central nervous system, MOS = medial olivocochlear system, OAEs = otoacoustic emissions, OHCs = outer hair cells, TEOAEs = transient evoked otoacoustic emissions
Maximum Length Sequences-Auditory Brainstem Responses from Children with Auditory Processing Disorders
Authors: Jirsa Robert E. 
Published: February 2022

AbstractThis study was designed to evaluate maximum length sequences-auditory brainstem responses (MLS-ABR) in children with auditory processing disorders and to compare these results with a normal control group matched for age, intelligence, and gender. Although each waveform was analyzed for the presence of waves 1,111, and V, the primary focus was wave V. Although absolute latency measures for wave V were obtained from all subjects, waves I and III were not always identified. Although the results showed latency increases for all waveforms in both groups, the only significant difference noted was an increase in wave V latency for both the left and right ears in the clinical group. These results suggest that the MLS-ABR may be useful in the assessment of auditory processing disorders. Implications for the potential use of the MLS-ABR in management programs are discussed.
Abbreviations: ABR = auditory brainstem response, ADHD = attention-deficit hyperactivity disorder, APD = auditory processing disorders, DD = Dichotic Digits Test, DP = Duration Pattern Test, DS = Dichotic Sentences Identification Test, ERP = event-related potential, FP = Frequency Pattern Test, LL = linguistic label, MLR = middle latency response, MLS = maximum length sequences, MLS-ABR = maximum length sequences-auditory brainstem response, MMN = mismatch negativity, SSI-ICM = Synthetic Sentence Identification-Ipsilateral Competing Message, TC = Time Compressed Speech Test, VA = Veterans Administration
Measurements of small optical absorption and scattering coefficients of high-power polarised laser radiation in lithium triborate crystals
Authors: Grishchenko I.V. , Vorob’ev A.K. , Ostapiv A.Yu. , Stirmanov Yu.S. , Konyashkin A.V. , Ryabushkin O.A. 
Published: February 2022

Abstract
We present the results of measurements of low optical absorption and scattering coefficients in lithium triborate crystals using the method of piezoelectric resonance laser calorimetry under the action of polarised single-mode laser radiation at wavelengths of 1070 and 532 nm in the power ranges of 50 – 300 and 5 – 50 W, respectively. It is shown that when radiation propagates along the crystal axis a, these coefficients remain constant in the specified power ranges and do not depend on the direction of laser radiation polarisation. The measured optical scattering coefficients are compared with the results obtained by the method of integrating spheres.
Pragmatically speaking
Authors: Derwing Tracey M. , Waugh Erin , Munro Murray J. 
Published: February 2022

Abstract
The relationship between second language (L2) comprehensibility and pragmatics is explored in two experiments involving instruction of speech acts to learners enrolled in a Language Instruction for Newcomers to Canada program. The study was designed to determine whether improved pragmatic competence results in enhanced comprehensibility (how easy L2 speech is to understand). Two intact classes participated; one received 25 hours of pragmatics instruction, while the control group received the standard curriculum (no focus on pragmatics). Both classes were recorded in role-plays based on several scenarios at pre- and post-test. Transcriptions of the role-plays were coded according to a rubric; although the control group showed superior performance at the outset, the experimental group’s scores exceeded those of the Control group at post-test with a medium effect size. A subset of pre- and posttest role-plays (two refusals and two requests) were randomly assigned to 56 native English listeners who rated the speech samples for social appropriateness, comprehensibility, and fluency. The experimental group’s posttest productions on all scenarios were perceived as significantly more socially appropriate, with three scenarios showing significant improvement in comprehensibility. Although one scenario improved in fluency, another showed a decline. The results suggest that pragmatics instruction enhances L2 speech comprehensibility.
Pluricentric linguistic justice in Quebec
Authors: Oakes Leigh , Peled Yael 
Published: February 2022

AbstractWith the emergence of the notion of Standard Quebec French, debates about linguistic usage in Quebec are today largely shaped by two competing normative models: an exonorm defined for all intents and purposes in France and an endonorm reflecting socially acceptable usage as determined by Quebec­ers themselves. While language attitude research has provided some indication of the normative preferences of ordinary Quebec­ers, the picture remains largely ambiguous. This article seeks to provide some clarity through a reconceptualisation of language attitudes intended to specifically elicit value judgments on norm setting and enforcement. Building on research in political philosophy and theory, it further develops the notion of ‘pluricentric linguistic justice’, proposed as a tool for assessing questions of authority and legitimacy concerning French in Quebec. It then presents the results of an empirical exploration of this notion focused on the attitudes of a sample of franco­phone Quebec­ers towards endonormativity, including as a function of key social variables. The study represents an innovative attempt to develop and test a methodological instrument for interrogating questions of linguistic justice in pluricentric settings more broadly.