bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized prediction of the results of reconstructive surgery for chronic otitis media
Authors: Dubinets I. D. , Korkmazov M. Yu. , Korkmazov A. M. , Sinitskii A. I. , Mokina M. V. 
Published: April 2022

Introduction. The goal of the surgical treatment of patients with chronic otitis media is to eliminate the consequences of the inflammatory and destructive disease while preserving the anatomy of the middle ear and improving auditory function. According to the literature, the outcome of middle ear reconstructive surgery for the surgeon and the patient in most cases remains unpredictable. The development of an integrated approach to predicting the results of reconstructive sanitizing surgery will make it possible to select the most effective surgical tactics in terms of treatment time and type of surgical intervention.Aim.To develop a methodology for personalized prediction of the result of operations on the temporal bone in patients with chronic otitis media and substantiate the choice of optimal surgical tactics, taking into account clinical and functional parameters.Materials and methods.A retrospective study was carried out to compare the data of patients with the use of the author’s personalized prognosis method: “A method for predicting the result of tympanoplasty” and “A method for predicting the degree of hearing loss in otosurgery for chronic otitis media” with the results of surgical treatment of 263 patients with chronic otitis media, operated on in hospitals in Moscow. Chelyabinsk in 2018–2020.Results and discussion. In the observation, the patients were divided into two groups according to the sum of points, which determined the volume, type and timing of the operation. The sum of points less than or equal to 20 was assessed as a favorable prognosis for reconstructive debridement surgery. The sum of points in the range from 21–40 was assessed as the possibility of carrying out onestage surgery for the purpose of sanitation and reconstruction, but the patient should be informed about the unfavorable prognosis for the restoration of hearing. A score greater than 40 is assessed as an unfavorable prognosis, with an indication for separate-stage surgery, indicating a socially significant hearing loss in the postoperative period in patients with chronic otitis media.Conclusion. A personalized approach to predicting the results of surgical treatment forms groups of patients with chronic suppurative otitis media and helps in choosing surgical tactics in terms of the type, volume and timing of one-stage or separatestage reconstructive surgery and the need for reoperation for a period of one year.
Factors affecting the content of Ig G-antibodies to S-protein SARS-CoV-2 in the blood of reconvalescents after new coronaviral infection (COVID-19)
Authors: Kryukov E. V. , Salukhov V. V. , Kotiv B. N. , Ovchinnikov D. V. , Andreychuk Yu. V. , Denisov D. G. , Bogomolov A. B. , Kharitonov M. A. , Rudakov Yu. V. , Sadovnikov P. S. , Chugunov A. A. 
Published: April 2022

Introduction. Morbidity and mortality of COVID-19 actualizes the identification of groups with the greatest risk of primary and re-infection, persons in need of priority vaccination or revaccination.Objective. To study the factors affecting the content of IgG antibodies to the S-protein SARS-CoV-2 in convalescents after suffering COVID-19 for 6 months.Materials and methods. The study of the Military Medical Academy and the Helix Laboratory Service was carried out from 06/01/2020 to 08/01/2021 on the basis of the Military Medical Academy and the Helix centers. The study included 1421 people – both sexes from 18 to 70 years old. 1205 with asymptomatic and mild disease (outpatient group). 216 with moderate or severe form (inpatient group). The outpatient group underwent a quantitative determination of IgG to the spike (S) protein SARS-CoV-2 by immunochemiluminescence analysis at 30, 45, 60, 90, 180 days from diagnosis. The diagnosis was verified by a positive RT-PCR result. The inpatient group underwent an identical study on the 1st, 14th, 45th, 60th, 90th and 180th days from the moment of admission to the hospital. The diagnosis was verified in the same way.Results. In convalescents, post-infectious immunity is formed from 30 days. Older age was associated with a more pronounced production of IgG to the S-protein SARS-CoV-2, mainly in older women. Moderate and severe course is characterized by higher concentrations of IgG to the SARS-CoV-2 S protein. A high level of IgG to the S-protein SARS-CoV-2 persists for up to 90 days, with a subsequent decrease by 180 days. Body weight, days of oxygen therapy, hyperthermia, the volume of lung tissue lesions and the level of C-reactive protein correlate with the concentration of IgG to the S-protein SARS-CoV-2. The use of glucocorticoids (GCS) is characterized by the presence of a higher concentration of IgG to the S-protein SARS-CoV-2 up to 6 months. There is a dose-dependent effect of using GCS.Conclusion. The formation and maintenance of the level of neutralizing antibodies for 6 months depends on the severity of the disease, the gender and age of the patients, and the fact of using GCS. This must be taken into account when carrying out therapeutic and preventive measures, planning vaccination.
Atorvastatin: old friend in the light of novel coronavirus infection’s pandemia
Authors: Ezhov M. V. , Kolmakova T. E. , Matveeva M. M. , Alekseeva I. A. 
Published: April 2022

The COVID-19 (COronaVIrus Disease 2019) pandemic caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus 2) continues to be a global threat to people and health systems. As of March 21, 2022, there are more than 460 million cases and more than 6 million deaths worldwide, and more than 17 million and 360,000 respectively in the Russian Federation. Due to the rapid spread of the new coronavirus infection, since the beginning of the pandemic, tremendous efforts have been made to create new pharmacological agents to reduce morbidity and mortality, and tactics have been used to repurpose existing medications in treatment regimens for patients with COVID-19, particularly statins. Statins represent one of the most widely used and prescribed classes of drugs in the world. The hypolipidemic properties of statins are actively used to treat hyperlipidemia and primary and secondary prevention of cardiovascular diseases and their complications. Statins have a known safety profile, are inexpensive and accessible. In addition to their hypolipidemic effects, statins have a wide range of pleiotropic anti-inflammatory, antiviral, and antithrombotic effects potentially useful in the treatment of COVID-19. Presumably, the use of statins can reduce SARS-CoV-2-induced organ and tissue damage and improve lung function. The use of statins, particularly atorvastatin, as one of the most effective, widely prescribed and studied drugs in this class, as a safe, affordable and relatively inexpensive therapy may be a promising therapeutic approach in the fight against a new coronavirus infection.
GCMs simulation-based assessment for the response of the Mediterranean Gaza coastal aquifer to climate-induced changes
Authors: Al-Najjar Hassan , Ceribasi Gokmen , Dogan Emrah , Ceyhunlu Ahmet Iyad , Abualtayef Mazen , Qahman Khalid 
Published: April 2022

AbstractIn the Eastern Mediterranean countries, groundwater contained in coastal aquifers is the predominant water source for supplying water. The Mediterranean Gaza coastal aquifer in Palestine is showing alarming signs of depletion due to climate change and human-caused influences that substantially impact the hydraulic performance of the Gaza coastal aquifer. The climate statistical modeling and the downscaling of the ensemble global climate model under the representative concentration pathway (RCP) scenarios of RCP 2.60, 4.50, and 8.50 refer to a future decreasing trend in the precipitation and an increasing trend in the temperature. The stochastic model refers to an average decrease of −5.2% in the rainfall every 20 years that coincides with the RCP scenarios that show a decrease in precipitation between 0 and −5%. The rate of temperature increase over the next 20 years is defined at +1 °C, which closely matches the RCP results. As a result of human fast-paced activities, groundwater consumption is expected to rise by nearly 55% by the end of 2040, to around 193 million cubic meters, with a substantial withdrawal trend in southern provinces of the Gaza Strip. Consequently, the aquifer model predicts that subsurface water levels might fall at a rate of −2.50% per year, reaching a level of around −27.77 m below the mean sea level (MSL) by 2040. Alternative water supplies, such as desalinated seawater and treated wastewater, with annual maximum volumes of 110 and 16.5 million cubic meters, respectively, are expected to perfectly recharge groundwater resources of the Gaza coastal aquifer at an annual rate of about +3.65% to meet a groundwater table level of around −5 m below the MSL by 2040.
HEC-HMS based rainfall-runoff model for Punpun river basin
Authors: Ranjan Shashi , Singh Vivekanand 
Published: April 2022

Abstract
Various hydrological models were used in different river basins to simulate the runoff on available rainfall, land use and soil property data. The HEC-HMS model is used by several researchers to estimate the water potential of the basin through rainfall-runoff modeling. In this study, a rainfall-runoff model for the Punpun river basin has been developed using HEC-HMS. Daily rainfall and runoff data from the years 2005 to 2017 were used for the development of model. ArcGIS has been used to analyze the hydrological parameters, preparation of LULC, soil and slope maps for the computation of curve number as input into the HEC-HMS model. Daily, monthly and monsoonal rainfall-runoff models have been developed. The performance of all the models has been evaluated using statistical indices–coefficient of determination (R2), Nash-Sutcliffe efficiency (NSE), percent bias (PBIAS) and RMSE-observations standard deviation ratio (RSR). R2 and NSE values for all the models are greater than 0.75 and PBIAS is less than 10, which shows very good results from all the models except the daily model, in which NSE values are less than 0.75. Based on statistical indices, the monthly model performs better than the daily and monsoonal models.
Resistance of anaerobic activated sludge acclimated by different feeding patterns: response to different stress shocks
Authors: Lu Fuzhi , Huang Luodong , Qian Feng , Jiang Qiong , Khan Sohail , Shen Peihong 
Published: April 2022

Abstract
Anaerobic activated sludge plays a key role in the anaerobic digestion (AD) treatment of wastewater. The ability of anaerobic activated sludge to endure stress shock determines the performance of AD. In this study, the resistance of anaerobic activated sludge acclimated by three feeding patterns (continuous, semi-continuous, and pulse) to four stress shocks, including low pH influent, high OLR (organic loading rate), high ammonium and high sulfate, was investigated respectively. The results showed that the anaerobic activated sludge acclimated by semi-continuous feeding had the best resistance to high OLR shock, followed by pulse feeding, and then continuous feeding. There was no significant difference in the resistance of the three activated sludge to the other stress shocks. Under stress shock, the microbial community structure and abundance of specific functional microorganisms in the activated sludge acclimated by different feeding patterns varied, while the relative abundance of Methanosarcinaceae in the anaerobic activated sludge increased. The variation in the relative abundance of specific functional microorganisms was in charge of the differences in the resistance of anaerobic activated sludge. Overall, the results presented herein provide reference for improving the stability and effectiveness of activated sludge under adverse conditions.
Stigmatizing Attitudes Across Cybersuicides and Offline Suicides: Content Analysis of Sina Weibo
Authors: Li Ang , Jiao Dongdong , Zhu Tingshao 
Published: April 2022

Background
The new reality of cybersuicide raises challenges to ideologies about the traditional form of suicide that does not involve the internet (offline suicide), which may lead to changes in audience’s attitudes. However, knowledge on whether stigmatizing attitudes differ between cybersuicides and offline suicides remains limited.

Objective
This study aims to consider livestreamed suicide as a typical representative of cybersuicide and use social media data (Sina Weibo) to investigate the differences in stigmatizing attitudes across cybersuicides and offline suicides in terms of attitude types and linguistic characteristics.

Methods
A total of 4393 cybersuicide-related and 2843 offline suicide-related Weibo posts were collected and analyzed. First, human coders were recruited and trained to perform a content analysis on the collected posts to determine whether each of them reflected stigma. Second, a text analysis tool was used to automatically extract a number of psycholinguistic features from each post. Subsequently, based on the selected features, a series of classification models were constructed for different purposes: differentiating the general stigma of cybersuicide from that of offline suicide and differentiating the negative stereotypes of cybersuicide from that of offline suicide.

Results
In terms of attitude types, cybersuicide was observed to carry more stigma than offline suicide (χ21=179.8; P<.001). Between cybersuicides and offline suicides, there were significant differences in the proportion of posts associated with five different negative stereotypes, including stupid and shallow (χ21=28.9; P<.001), false representation (χ21=144.4; P<.001), weak and pathetic (χ21=20.4; P<.001), glorified and normalized (χ21=177.6; P<.001), and immoral (χ21=11.8; P=.001). Similar results were also found for different genders and regions. In terms of linguistic characteristics, the F-measure values of the classification models ranged from 0.81 to 0.85.

Conclusions
The way people perceive cybersuicide differs from how they perceive offline suicide. The results of this study have implications for reducing the stigma against suicide.
NEW ALTITUDINAL RECORD OF Heloderma horridum (WIEGMANN, 1829) (SQUAMATA: HELODERMATIDAE)
Authors: Arenas Moreno Diego Miguel , Bautista del Moral Adán , Brindis Badillo David Alejandro 
Published: April 2022

Heloderma horridum (Beaded Lizard) is a venomous lizard of large size distributed along the Pacific Coast of Mexico from Sinaloa to Chiapas, and in lowlands of the states of Estado de México, Morelos and Puebla (Reiserer et al., 2013). This lizard inhabits mostly in tropical dry forest at lowlands; however, it occasionally occurs in temperate habitats at high elevation up 1800 m (Guadarrama et al., 2019). In this study, we extend the altitudinal range of H. horridum in more than 200 m elevation.
Adaptación y validación de un instrumento para evaluar los estereotipos negativos de la vejez
Authors: Gonzalez-Salas Isabel Cristina , Juárez-Hernández Luis Gibran , Gámez-Mier Carlos Humberto 
Published: April 2022

Introducción: Los instrumentos para la identificación de estereotipos negativos de la vejez son abundantes; sin embargo, la mayoría proceden de otras regiones o contextos y se aplican sin efectuar un proceso de adaptación y validación.Objetivo: Se realizó la adaptación del instrumento cuestionario de estereotipos negativos hacia la vejez (CENVE) para el contexto de estudiantes mexicanos de medicina.Método: Para su adaptación se realizó una revisión a detalle de la terminología y aspectos gramaticales de los ítems, posterior a esta fase, el instrumento fue revisado por cinco expertos con el objetivo de determinar la pertenencia y relevancia de los ítems. Al concluir esta fase, el instrumento se sometió a juicio de once expertos para analizar su validez de contenido. Finalmente, para evaluar la adecuación del instrumento al grupo objetivo, se realizó un estudio piloto con 34 estudiantes de medicina.Resultados: Los expertos avalaron la pertenencia y relevancia de los ítems y, acorde a sus sugerencias, se realizaron mejoras en la redacción de los ítems. En el juicio de expertos, todos los ítems fueron validados en contenido (V de Aiken >0.75; VI >0.50). La percepción del grupo piloto respecto a la comprensión de las instrucciones e ítems fue de excelente grado. La confiabilidad en esta aplicación fue favorable (alfa de Cronbach: 0.847; IC al 95%: 0.760 ± 0.913).Conclusiones: Se presenta la adaptación de un instrumento para evaluar los estereotipos negativos hacia la vejez para el contexto mexicano, el cual se comprobó mediante un proceso de validación que posee validez de contenido.
Propiedades Psicométricas del Test de Empatía Cognitiva y Afectiva (TECA) en Población Mexicana
Authors: Chavira Trujillo Gabriel , Celis de la Rosa Alfredo 
Published: April 2022

Introducción: Evaluar la empatía es cada vez más necesario dentro de diferentes áreas de investigación. Objetivo: El presente estudio presenta un análisis de las propiedades psicométricas del cuestionario Test de Empatía Cognitiva y Afectiva (TECA) que evalúa la empatía desde una perspectiva integral; siendo uno de los pocos construidos originalmente en el lenguaje español. Método: Sé evaluó la fiabilidad y validez de constructo en 607 adultos (137 hombres/ 470 mujeres) estudiantes de población mexicana. Resultados: Los resultados muestran una adecuada fiabilidad del instrumento en general (α = .86). Sin embargo, los análisis factoriales exploratorios y confirmatorios sugiere la necesidad de revisar los ítems. Discusión: La incorporación de metodologías robustas que consideran la naturaleza ordinal de las escalas Likert, como el análisis factorial con la incorporación del intercepto aleatorio permiten mejorar el ajuste de los modelos sin alterar la estructura factorial original. Por último, la invariancia métrica no es alcanzada entre la muestra española original y la mexicana. Conclusiones: El TECA se puede aplicar en población mexicana pero se sugiere una revisión en la construcción de los ítems.
Characteristics of Knowledge, Attitudes, and Behaviors of Women Aged 35 - 45 Years in Facing Menopause in Kelurahan Cawang Rw 06 East Jakarta 2016
Authors: Suryanegara Wiradi , Sirait Batara Imanuel 
Published: April 2022

Results from the 2010 population census by the department of health show that Indonesia is one of the top 5 countries of older people living in the world, with 18.1 million people or about 9.6% of the population in Indonesia. Based on the data from the WHO, in 2010, the number of women who has menopause in Asia by the year 2025 will reach 373 million people. The average menopause age in Indonesia is around 49 years old, but women above the age of 40 already have irregular menstruation cycles. This research hopes to know the knowledge, attitude, and behaviour of women aged 35-45 years old in the Cawang region RW 06 in 2016. This research is descriptive survey research and was done in September through October with 70 respondents. In this research, 17.1% of the respondents know about menopause well, 60% knows about menopause quite well, and 22.9% do not know about menopause very well.51.4% of the respondents respond well towards menopause, and 48.6% does not respond well to menopause. Facing menopause, 64.3% of the respondents are ready for menopause, and 35.7% are not ready for menopause.
Keywords: knowledge, attitude, behaviour, menopause
Formulation and Evaluation of a Laterite Soil Based Scrubbing Effect Herbal Cleansing Bar
Authors: Dissanayake N.U. Sandali , Pupulewatte P.G. Heshani , Jayawardana Daham T. 
Published: April 2022

Cosmetics play a dynamic role for every person to have a glad and confident life. In the current scenario, herbal cosmeceuticals have more demand because they have no side effects. People often suffer from acne, whiteheads, and blackheads, so scrubbing becomes essential. The main objective of the present study was to prepare a herbal-mineral facial scrubbing effect cleansing bar. Majorly facial skin comes in direct contact with dirt, pollution, dust particles, and many dead cells. Some facial preparations are required to remove the dead cells and make the skin in fine fettle, cleaned, and nourished. The present study formulated a laterite soil-based herbal scrubbing effect cleansing bar for all typed skin using laterite soil powder. In contrast, glycerin soap base, virgin coconut oil, olive oil, bee honey, aloe vera, lime juice, turmeric, and lavender essential oil are used and evaluated by using various parameters such as physical appearance, color, odor, pH, washability, irritants, stability studies, microbial tests, heavy metals, and total fatty matter. It was given fruitful results with all the tests. The herbal formulation had characteristic pleasant order, reddish-brown in color having, light, non-irritant to the skin and quite an elegant, microbial and heavy metal safe product. Thus, the formulated scrubbing effect facial cleansing bar can be utilized efficaciously without a side effect that exfoliates makes healthy, clean, and glowing skin.
Keywords: Facial scrub, Cosmetic, Herbal, Mineral, Laterite soil
Marine doctor privat-doctor Petr Fedorovich Fedorov: services, contribution to medicine and assessment of its activities by our contemporaries
Authors: Iordanishvili A. K. 
Published: April 2022

Introduction. Currently, the role of the Military Medical Academy is named after S. M. Kirov in the development of the world and domestic medical science, as well as in the creation of scientific medical schools. Despite the fact that the Department of Dentistry at the Military Medical Academy was formed in 1929, the influence of the Academy on the development of domestic dentistry can be traced throughout the entire period of its existence. However, not all historical moments of the formation and development of military dentistry are known to a wide range of specialists.The purpose of the study was to highlight the merits of the marine doctor, doctor of medicine, privat-docent P. F. Fedorov, pointing out his role in the formation and development of dentistry in our country.Material and methods. Based on the analysis of domestic literature, as well as the life, professional activities, and scientific works of the doctor of medicine, privat-docent P. F. Fedorov, his role in the formation and development of dentistry in Russia is presented.Results and discussion. The main milestones in the life, professional medical, and pedagogical activities of the marine doctor P. F. Fedorov from the moment he entered the Imperial Medical-Surgical Academy (1876) until his appointment to the active fleet in connection with the outbreak of the First World War (1914). Particular attention is paid to the activities of P. F. Fedorov as a private assistant professor for dental diseases of the Imperial Military Medical Academy, where he headed the course on dental diseases for 22 years. It is noted that the assistant professor of dental diseases at the Imperial Military Medical Academy was a kind of prototype for the future department of maxillofacial surgery and stomatology of the Military Medical Academy. Conclusion. Marine doctor privat-docent P. F. Fedorov was one of the founders of a new specialty — dentistry (military and practical), as he stood at its origins.