bluuebunny/crossref_metadata_2025_split huggingface dataset:
INVESTIGACIÓN CUANTITATIVA E INVESTIGACIÓN CUALITATIVA: BUSCANDO LAS VENTAJAS DE LAS DIFERENTES METODOLOGÍAS DE INVESTIGACIÓN
Authors: Ugalde Binda Nadia , Balbastre-Benavent Francisco 
Published: November 2022

El proceso investigativo tiene como propósito final producir conocimiento a través de la resolución del problema establecido al inicio del estudio. Así pues, bajo la etiqueta demetodología de investigación se hace referencia a todas las decisiones que el investigador toma para alcanzar sus objetivos, las cuales se enfocan en aspectos tales como el diseño de la investigación, la estrategia a utilizar, la muestra a estudiar, los métodos empleados para recoger los datos, las técnicas seleccionadas para el análisis de los resultados y los criterios para incrementar la calidad del trabajo, entre otras. Los diseños de investigación actuales giran en torno a dos grandes paradigmas: el modelo cuantitativo y el modelo cualitativo. Este artículo hace una revisión teórica de ambos modelos y explica en qué consisten y cuándo es apropiado utilizar cada uno.
Assessment of oral, dental and facial pain in patients
Authors: Rastogi Isha 
Published: November 2022

Discomfort or pain in mouth is a common problem. It needs to be fully catered to and treated at the earliest.To find out causes of oral pain in patients.500 patients above 20 years were chosen.Patients have various reasons of oral pain, but they are careless.Patients suffer oral pain and some accept it as part of their living.Oral pain should be thoroughly evaluated and taken care of in diagnosis.
Narrating Wonder in Mark Anthony Jarman’s Stories
Authors: Blake Jason 
Published: November 2022

Mark Anthony Jarman’s characters are often down and out, and often wandering and wondering. Using theories of wonder, this essay argues that wonder plays a key role in many of Jarman’s stories—stories that are marked not by narrative or psychological closure, but by a sense of wonder as characters muse on their lot in life. After briefly considering Jarman’s role within Canadian literature, including his innovative approaches to the short story form, and his odd status as an influential yet often ignored writer, the essay moves to a discussion of the various ways that wonder is at play in his works, both as a verb and a state. Jarman’s characters are frequently in doubt, and the act of wondering takes us into their drifting, self-reflecting minds. However, there is also the sense of wonder as the miraculous. Jarman’s narrators find optimism in the world around them, thanks to flashes of the beauty of the unlikely. Wonder, thus, has a crucial structural function.
Elbow arthroplasty for advanced inflammatory elbow disease—rheumatoid arthritis and pigmented villonodular synovitis
Authors: Liu Xin , Hao Chen , Du Bin , Xue Peng , Xi Hongzhong , Sun Guangquan 
Published: November 2022

Abstract
Background
Total elbow arthroplasty is the treatment for end-stage elbow disease. In contrast to severe fractures and degenerative disease, inflammatory elbow disease is characterized by osteoporosis and surrounding soft tissue disorders.
Aims
To evaluate the clinical efficacy of total elbow arthroplasty, and to discuss the surgical skills and complication management of patients who received surgery through the retrospective analysis of the clinical and follow-up data.
Methods
13 patients with advanced inflammatory elbow disease treated with semi-restricted CM prosthesis in the Department of Orthopedics of Affiliated Hospital of Nanjing University of Chinese Medicine from January 2014 to June 2020. Through the retrospective analysis of the clinical and follow-up data, the clinical efficacy was evaluated, and the surgical skills and complication management of these patients were discussed.
Results
All patients were followed up for 13–89 months, with an average of (53.15 ± 24.20) months. The MEPS and HSS scores at each follow-up point after operation and at the last follow-up were satisfactory. There were 3 cases of periprosthetic fractures during the operation, 1 case of delayed incision healing, 1 case of ulnar nerve palsy, and 1 case of pain around the elbow joint after operation.
Conclusion
Elbow arthroplasty can effectively relieve joint pain, correct joint deformity, improve joint stability, and restore elbow joint function for patients with advanced inflammatory disease of the elbow joint.
Epidemics in native species influence the outcome of a species invasion
Authors: Blackwood Paradyse , Jonasen Kacie L. , Heil Brittany N. , Searle Catherine L. 
Published: November 2022

Abstract
Invasive species can have large effects on native communities. When native and invasive species share parasites, an epidemic in a native species could facilitate or inhibit the invasion. We sought to understand how the size and timing of epidemics in native species caused by a generalist parasite influenced the success and impact of an invasive species. We focused on North American native and invasive species of zooplankton (Daphnia dentifera and Daphnia lumholtzi, respectively), that can both become infected with a fungal parasite (Metschnikowia bicuspidata). In a laboratory microcosm experiment, we exposed the native species to varying parasite concentrations (none, low, high) and two invasive species introduction times (before or during an epidemic in the native species). We found that none of our treatments affected densities or infection (measured as number infected or prevalence) of the invasive species, but there were more resting eggs of the invasive species in the absence of the parasite. The density of the native species was lowest with a combination of the parasite present, and the invasive species introduced during the epidemic; infection prevalence in these treatments was also higher than prevalence in treatments where the invasive species was introduced before the epidemic. Therefore, the timing of an invasion during an epidemic can affect the native species, even when there is no measurable effect of invasion timing on the invasive species. Our results suggest that the size and timing of epidemics in native species can influence the impacts of a species invasion.
Short-term exposure to extreme temperature and outpatient visits for respiratory diseases among children in the northern city of China: A time-series study
Authors: Wu Ya , Liu Xiaobo , Gao Lijie , Sun Xiaohong , Hong Qianqi , Wang Qian , Kang Zhen , Yang Chao , Zhu Sui 
Published: November 2022

Abstract
Background
Although studies have indicated that extreme temperature is strongly associated with respiratory diseases, there is a dearth of studies focused on children, especially in China. We aimed to explore the association between extreme temperature and children’s outpatient visits for respiratory diseases and seasonal modification effects in Harbin, China.
Methods
A distributed lag nonlinear model (DLNM) was used to explore the effect of extreme temperature on the daily outpatient visits for respiratory diseases among children and lag effects as well as seasonal modification effects.
Results
Extremely low temperatures were defined as the 1st percentile and 2.5th percentile of temperature. Extremely high temperatures were defined as the 97.5th percentile and 99th percentile of temperature. At extremely high temperatures, both 26°C (97.5th ) and 27°C (99th ) showed adverse effects at lag 0–6 days, with relative risks (RRs) of 1.34 [95% confidence interval (CI): 1.21–1.48] and 1.38 (95% CI: 1.24–1.53), respectively. However, at extremely low temperatures, both − 26°C (1st ) and − 23°C (2.5th ) showed protective effects on children’s outpatient visits for respiratory diseases at lag 0–10 days, with RRs of 0.86 (95% CI: 0.76–0.97) and 0.85 (95% CI: 0.75–0.95), respectively. We also found seasonal modification effects, with the association being stronger in the warm season than in the cold season at extremely high temperatures.
Conclusions
Our study indicated that extremely hot temperatures increase the risk of children’s outpatient visits for respiratory diseases. Efforts to reduce the exposure of children to extremely high temperatures may have the potential to mitigate the burden of pediatric respiratory diseases, especially in the warm season.
Berberine mitigates acetamiprid induced hepatotoxicity and inflammation via regulating endogenous antioxidants and NF-κB/TNF-α signaling in rats
Authors: Phogat Annu , Singh Jagjeet , Kumar Vijay , Malik Vinay 
Published: November 2022

Abstract
Acetamiprid (ACMP) is a neonicotinoid insecticide used on a large scale and has been reported for oxidative stress mediated toxicity and physiological alterations in mammals. The plant-derived natural antioxidant berberine (BBR) possesses protective potential against inflammation, structural changes and cellular toxicity. The current study aimed to investigate the toxic effects of ACMP exposure and the antioxidative and anti-inflammatory efficacy of BBR in rat liver tissue. The results showed that acetamiprid exposure (21.7 mg/kg b.wt) significantly elicited oxidative stress as evidenced by lipid peroxidation, protein oxidation, depletion of endogenous antioxidants. Further, ACMP exposure elevated NF-κB, TNF-α, IL-1β, IL-6 and IL-12 expression and caused structural alterations in liver tissue. Biochemical results showed that BBR treatment (150 mg/kg b.wt) reduced damage to lipids and proteins, replenished GSH, enhanced SOD, catalase activities and offered antioxidative effects against ACMP toxicity. Also, BBR suppressed inflammation by regulating NF-κB/TNF-α signaling in hepatic tissue of ACMP intoxicated rats. Histopathological examination confirmed the hepatoprotective effects of BBR. Our findings indicate that BBR might be speculated as potential therapeutic agent against oxidative stress mediated hepatotoxicity.
Fibroblast growth factor receptor type 4 as a potential therapeutic target in clear cell renal cell carcinoma
Authors: Narisawa Takafumi , Naito Sei , Ito Hiromi , Ichiyanagi Osamu , Sakurai Toshihiko , Kato Tomoyuki , Tsuchiya Norihiko 
Published: November 2022

Abstract
Background
Several clear cell renal cell carcinoma (ccRCC) cases harbour fibroblast growth factor receptor 4 (FGFR4) gene copy number (CN) gains. In this study, we investigated the functional contribution of FGFR4 CN amplification in ccRCC.
Methods
The correlation between FGFR4 CN determined via real-time PCR and protein expression evaluated by western blotting and immunohistochemistry was assessed in ccRCC cell lines (A498, A704, and 769-P), a papillary RCC cell line (ACHN), and clinical ccRCC specimens. The effect of FGFR4 inhibition on ccRCC cell proliferation and survival was assessed via either RNA interference or selective FGFR4 inhibitor BLU9931, followed by MTS assays, western blotting, and flow cytometry. To investigate FGFR4 as a potential therapeutic target, a xenograft mouse model was administered BLU9931.
Results
Sixty percent of ccRCC surgical specimens harboured an FGFR4 CN amplification. FGFR4 CN was positively correlated with its protein expression. All ccRCC cell lines harboured FGFR4 CN amplifications, while ACHN did not. FGFR4 silencing or inhibition attenuated intracellular signal transduction pathways, resulting in apoptosis and suppressed proliferation in ccRCC cell lines. BLU9931 suppressed tumours at a tolerable dose in the mouse model.
Conclusion
FGFR4 contributes to ccRCC cell proliferation and survival following FGFR4 amplification, making it a potential therapeutic target for ccRCC.
The utilisation of a cyclone ventilator with the addition of an activated carbon filter to improve room air quality in a TB patient's home
Authors: khambali khambali , Rachmaniyah Rachmaniyah , Roslan Rosidi , Wardoyo Slamet 
Published: November 2022

Abstract
The presence of air pollutants in the room can cause health problems in the long and short term. Indication of air pollution is the presence of CO and dust or particulates and bacteria. In addition to CO air pollutant substances and dust in the room, bacteria due to droplets is a severe problem. This study aimed to analyze the modification of a cyclone ventilator with the addition of an activated carbon filter to improve room air quality. This research is an experiment with an application in a natural environment in the form of a One Group Pre-Post Test Design. The air parameters analyzed were temperature, humidity, air flow rate, particulate meter (PM 2.5 ), and total bacteria in the room. The results show that the use of a cyclone ventilator with the addition of an activated carbon filter can improve indoor air quality for temperature parameters from 28.37 o C to 20.54 o C, humidity from 65.61–52.22%, PM 2.5 from 53.41 to 40.66 and air microbiology from 123.04 CFU to 66, 40 CFU and the airflow rate increased from 0.15 m/s to 0.29 m/s. Statistically, there was a significant difference (p ≤ 0.001) for all parameters measured before and after using a cyclone ventilator.
Who pays?—Reorganizing tax burden based on purchasing power
Authors: Tominaga Kazuto 
Published: November 2022

Abstract
People generally believe that a tax levied on sellers of some commodity is at least partly paid by buyers if its price rises. Contrary to this shared belief, this paper demonstrates, based on the formal treatment of purchasing power, that such ``shifting of tax burden'' does not occur in essence. Thus indirect taxes that assume such shifting are no different from direct ones in respect of tax payment: sellers pay the whole tax, and buyers only suffer a diminution in the value of their monetary assets by the price rise. We show a possible cause of the misconception is cognitive biases, including money illusions. We also examine how tax payment and economic incidence differ and show that economic incidence, the widely accepted measure of changes in welfare, cannot be a yardstick for evaluating ``who pays the tax'' at the same time. In addition, we discuss other types of taxes where a taxpayer does not deliver the tax directly to the government, such as withholding income taxes. We thereby show that the taxpayer pays the tax as intended (i.e., paid by employees in this case) owing to the explicit designation of taxpayers by law, in contrast to ``indirect'' taxes.
JEL Classification: H20 , H22 , K34
Competition for water and rapid exclusion of an island endemic by a pantropical species in a tropical climate
Authors: Gomes Anabele S. , Callaway Ragan M. , Rabelo Bruno S. , Petry Graziela L. , Barbosa Eduardo M. , Borghetti Fabian 
Published: November 2022

Abstract
Water availability has major effects on community structure and dynamics globally, yet our understanding of competition for water in the tropics is limited. On the tropical Trindade Island, we explored competition for water in the context of the rapid exclusion of an endemic sedge, Cyperus atlanticus, by a pantropical shrub, Guilandina bonduc. Guilandina patches were generally surrounded by rings of bare soil, and dead Cyperus halos commonly surrounded these bare zones. With geo-referenced measurements, we showed that Guilandina patches and bare soil zones rapidly expanded and replaced adjacent Cyperus populations. We found that soil water potentials were much lower in bare soils than soils under Guilandina or Cyperus, and that leaf water potentials of Cyperus plants were lower when co-occurring with Guilandina than when alone. When Guilandina was removed experimentally, Cyperus populations expanded and largely covered the bare soil zones. Our results indicate that when Guilandina establishes, its root systems expand beyond its canopies and these roots pull water from soils beneath Cyperus and kill it, creating bare zone halos, and then Guilandina expands and repeats the process. This scenario indicates rapid competitive exclusion and displacement of an endemic by a common pantropical species, at least in part through competition for water.
Immobilization of Cr (III) on the surface of natural asphalt sulfonic acid (NASA): novel and efficient nanocatalyst for the oxidation of sulfides
Authors: Soleiman-Beigi Mohammad , Abdi Mahsa , Kohzadi Homa 
Published: November 2022

Abstract
In this research, we reported synthesis of NASA@Cr(III) nanoparticles using natural asphalt. Characterization of this heterogeneous nanocatalyst was performed using various analysis including FT-IR, SEM, EDX, XRD, TGA and BET techniques. Then activity of the NASA@Cr(III) nanoparticles in the chemoselective oxidation of sulfides, was investigated. Use of this nanocatalyst for the oxidation of sulfides have features such as green condition, high yield, low time and reusability of the catalyst for the several times.
The contribution of large-scale atmospheric circulation to variations of observed near-surface wind speed across Sweden since 1926
Authors: Minola Lorenzo , Lönn Jessika , Azorin-Molina Cesar , Zhou Chunlüe , Engström Erik , Wern Lennart , Hellström Sverker , Zhang Gangfeng , Shen Cheng , Pezzoli Alessandro , Chen Deliang 
Published: November 2022

Abstract
This study investigates the centennial-scale (i.e., since 1926) variability of observed near-surface wind speed across Sweden. Results show that wind speed underwent various phases of change during 1926–2019: (a) a clear slowdown during 1926–1960; (b) a stabilization from 1960 to 1990; (c) another clear slowdown during 1990–2003; (d) a slight recovery/stabilization period for 2003–2014, which may continue with a possible new slowdown. Furthermore, the performance of three reanalysis products in representing past wind variations is evaluated. The observed low-frequency variability is properly simulated by the selected reanalyses and is linked to the variations of different large-scale atmospheric circulation patterns (e.g., the North Atlantic Oscillation). However, the evident periods of decreasing trend during 1926–1960 and 1990–2003, which drive most of the stilling in the last century, are missing in the reanalyses and cannot be realistically modeled through multiple linear regression by only using indexes of atmospheric circulation. Therefore, this study reveals that changes in large-scale atmospheric circulation mainly drives the low-frequency variability of observed near-surface wind speed, while other factors (e.g., changes in surface roughness) are crucial for explaining the periods of strong terrestrial stilling across Sweden.
A novel cuproptosis-related prognostic long non-coding RNAs signature model in neuroblastoma
Authors: Chen Ke , Wang Jing , Xiao Jun , Li Zejian , Zhao Xiang , Chen Xuyong , Meng Xinyao , Feng Jiexiong 
Published: November 2022

Abstract
Background
Neuroblastoma (NB) is the most common malignant solid tumor of the autonomic nervous system in children, which exhibits diverse with dramatic clinical behaviors. Cuproptosis, as a novel form of cell death, has already caused the extensive attention. However, the prognostic value of cuproptosis-related genes (CRGs) in NB remains unelucidated. In this research, we aimed to identify the association and construct a prognostic multigene signature of CRGs and cuproptosis-related long-chain non-coding RNAs (CRlncRNAs).
Methods
Obtaining RNA-sequence profiles and corresponding clinical data of NB patients from The Cancer Genome Atlas (TCGA, https://portal.gdc.cancer.gov/, accessed on 22 June 2022) database. Next, constructing the co-expression of CRGs and CRlncRNAs, and utilizing lasso, univariate Cox and multivariate Cox regression analysis to develop a prognostic signature. Then, Kaplan-Meier analysis was used to compare the overall survival (OS) among the groups classified by median CRlncRNAs signature score. Moreover, GO/KEGG enrichment analysis, tumor mutation burden (TMB), immune infiltration and CIBERSORT were conducted in high-risk and low-risk groups.
Results
CRlncRNA DIRC3-AS1, FOXN3-AS1, LINC00682, RASSF8-AS1 formed the prognostic signature model and patients with high-risk score were demonstrated to have a poor OS (Hazard ratio: 1.177, 95% CI: 1.066-1.300, p < 0.001). Besides, the accuracy of this model was verified by receiver operating characteristic (ROC) and principal component analysis (PCA). Furthermore, prognostic nomogram showed that the risk group of CRlncRNAs signature model appeared to have the ability of prognostic prediction. After that, TMB revealed that there was no statistical difference of genetic alterations in low-risk and high-risk group patients. Immune infiltration was also evaluated and revealed that immune functions were enriched in low-risk group.
Conclusion
The CRlncRNAs signature model presented to have efficacious prognostic value in profiles of NB patients.
Electrochemical machining properties and blades manufacturing of forged Ti-48Al-2Cr-2Nb intermetallic in sodium nitrate solution
Authors: Wang Yudi , Xu Zhengyang 
Published: November 2022

Abstract
Electrochemical machining (ECM) has great advantages for the manufacture of difficult-to-cut γ-TiAl alloys considering its many inherent advantages over traditional cutting techniques. In this study, the ECM characteristics of a new forged Ti-48Al-2Cr-2Nb (TiAl 4822) intermetallic with α and γ phases were investigated in NaNO3 solution. The polarization characteristics of the sample were studied by potentiodynamic and potentiostatic polarization tests. The results show that the alloy has typical active, passive, and transpassive regions, and the compactness and corrosion resistance of passive film are getting better and better with the increase of test time at passive potential. The XPS test revealed that the main components of the passive film are titanium dioxide and aluminum oxide. Furthermore, the alloy exhibits high material removal rates that remain almost constant in the range of current density less than 50 A/cm2. Moreover, the dissolution mechanism of TiAl 4822 alloy was also revealed through the dissolution morphology, elemental composition, surface roughness, and intergranular corrosion at different current densities. The sample shows a loose lamellar dissolution morphology and is very rough at low current density. The sample exhibits a very flat surface at high current density, but many micro-bulges with high content of Cr element on the dissolved surface. Finally, several forged TiAl 4822 alloy blades were successfully fabricated with an average surface roughness of Ra 0.55µm. It is prove that ECM can obtain high surface quality and high material removal rate of forged TiAl 4822 alloy for complex structural components in aero-engines.