bluuebunny/crossref_metadata_2025_split huggingface dataset:
Speech-Language Pathologists' Feelings and Practices Regarding Technological Apps in School Service Delivery
Authors: Olszewski Arnold , Smith Erika , Franklin Amber D. 
Published: August 2022

Purpose:
Thousands of technological applications (apps) have emerged in the past decade, yet few studies have examined how apps are used by speech-language pathologists (SLPs), their effectiveness, and SLPs' feelings regarding their use. This study explored how SLPs use apps and their feelings regarding their use in schools, as well as considerations made by SLPs prior to implementing apps in therapy sessions.

Method:
A survey was distributed electronically to school-based SLPs in Ohio, yielding 69 valid responses. The study probed SLP demographics, patterns of app use in schools, and feelings toward their use in a school setting.

Results:
Results showed 77% of SLPs reported using apps in their treatment sessions and reported generally positive feelings regarding app use. SLPs considered factors such as age, cognitive ability, and treatment targets when using apps in treatment. SLPs who reported not using apps cited personal preference and price as the most common factors influencing their decision. SLPs also noted concerns about excessive screen time.

Conclusions:
Results of this study carry clinical implications for future development and assessment of technology to be used for service delivery in schools. Given that the majority of school-based SLPs report using apps with their students, research on the role of apps in supporting learning for speech-language services is urgently needed.
Active vibration on offshore steel jacket platforms including delayed probabilistic actuator failures and resilient reliable sampled‐data control
Authors: Manivannan R. , Cao Yang , Chong Kil To 
Published: August 2022

AbstractThis paper examines the unified dissipative performance of Offshore Steel Jacket Platforms (OSJPs) which include actuator failures and probabilistic delays, through a resilient and reliable sampled‐data controller. In detail, random variables fetching the Bernoulli distribution are treated in particular for the stochastic time‐delays. By implementing the Lyapunov–Krasovskii functions(LKF) together with the Second Order Bessel–Legendre Inequality Technique (SOBLIT) and an improved Reciprocally Convex Inequality (RCI) approach, which provides impressive information about sampling to guarantee that the OSJP is unified dissipative. The proposed criterion is exhibited in the sort of linear matrix inequalities (LMIs) and highlights of this study is to examine the multi‐dynamic interpretation of OSJP with extended dissipativity indices. The advantage of the established methodology is explored for OSJPs with the existing results, which is carried out along with the proposed control law, using their values of the experimental parameters.
Diameter of the Cochlear Nerve Canal predicts Cochlear Nerve Deficiency in Children with Sensorineural Hearing Loss
Authors: Sorge Martin , Sorge Ina , Pirlich Markus , Fuchs Michael , Meuret Sylvia , Hirsch Franz Wolfgang , Dietz Andreas , Gräfe Daniel 
Published: August 2022

Purpose Detection of cochlear nerve deficiency (CND) is usually straightforward using magnetic resonance imaging (MRI). In patients in whom MRI cannot be performed or imaging provides equivocal findings, computed tomography (CT) of the temporal bone might offer indirect evidence of CND. Our study aimed to derive a cut-off value for the diameter of the cochlear nerve canal (CNC) and internal auditory canal (IAC) in temporal bone CT to predict CND.
Materials and Methods This retrospective study included 70 children with sensorineural hearing loss (32 with CND and 38 control patients). The height, width, and cross-sectional area of the IAC and diameter of the CNCs were determined using temporal bone CT. Receiver operating characteristic (ROC) and Student’s t-tests were performed for each parameter.
Results The mean diameter of the CNCs was significantly smaller in children with CND than in the control group (1.2 mm versus 2.4 mm, p < .001). The optimal threshold for CNC for separation of the two groups was 1.9 mm, resulting in a sensitivity of 98.7 % and specificity of 89.2 %. The IAC dimensions could not distinguish between children with CND and controls.
Conclusion A CNC diameter of less than 1.9 mm is a reliable predictor of CND in children with sensorineural hearing loss.
Key Points:
Citation Format
Diagnostik und Management der perioperativen Myokardischämie im Rahmen elektiver Eingriffe bei Aortenaneurysmen
Authors: Dovzhanskiy Dmitriy I. , Bischoff Moritz S , Jäckel Petra , Boeckler Dittmar 
Published: August 2022

Zusammenfassung
Einleitung Die perioperative Myokardischämie (PMI) stellt eine schwerwiegende postoperative Komplikation dar. Insbesondere die Aortenchirurgie gehört zu den Hochrisikoeingriffen in Bezug auf das kardiale Operationsrisiko. Ziel dieser Arbeit ist es, die Krankheitsverläufe von Patienten mit PMI nach elektiven Aortenaneurysmen-Operationen zu untersuchen.
Patienten und Methoden Es handelt sich um eine retrospektive Datenanalyse von elektiv im Zeitraum Januar 2005 bis Januar 2012 in der Klinik für Gefäßchirurgie und Endovaskuläre Chirurgie des Universitätsklinikums Heidelberg an der Aorta wegen Aneurysma operierten Patienten. Die Diagnose PMI wurde anhand einer Erhöhung des Serumtroponins gestellt. Es erfolgte eine Charakterisierung der PMI bezüglich des Zeitpunkt ihres perioperativen Auftretens, der klinischen Symptomatik sowie Besonderheiten der durchgeführten Diagnostik. Des Weiteren wurden Therapie-, Entlass- und Verlegungsmanagement analysiert.
Ergebnisse Insgesamt wurden im angegebenen Zeitraum 863 Patienten einem elektiven Aorteneingriff unterzogen. Eine PMI wurde bei 31 (3,6%) Patienten beobachtet, wobei in 21 von 31 (67,7%) Fällen eine konventionelle Operation erfolgt war. Bei 24 Patienten (77,4%) trat eine PMI während der ersten 3 postoperativen Tage auf. Mehr als die Hälfte der Patienten (16/31) waren klinisch asymptomatisch, in 77,4% der Fälle (24/31) war das Elektrokardiogramm unauffällig. In 25,8% der Patienten (8/31) lag der primäre Serumtroponinwert im Normbereich. Eine rein medikamentöse Therapie erfolgte in 17 Fällen (54,8%). Eine interventionelle Behandlung im Sinne einer Herzkatheteruntersuchung wurde in 12 Fällen (38,7%) durchgeführt, bei 2 (6,5%) Patienten wurde eine notfallmäßige aortokoronare Bypassanlage durchgeführt. Insgesamt 14 (45,1%) Patienten konnten direkt nach Hause entlassen werden, weitere 14 (45,1%) Patienten wurden zur Weiterbehandlung der PMI in ein Akutkrankenhaus
(einschließlich hausinterne Verlegung) verlegt. Zwei Patienten verstarben während des Krankenhausaufenthalts an Multiorganversagen.
Schlussfolgerung Die PMI ist eine häufige Komplikation im Rahmen elektiver Aorteneingriffe. Die Diagnostik der PMI kann bei gering ausgeprägter/okkulter Klinik im Rahmen der Intensivtherapie erschwert sein. Aufgrund der potenziell schwerwiegenden Folgen sollte eine Herzenzymdiagnostik frühzeitig eingeleitet werden, um eine zeitnahe kardiologische Therapie zu ermöglichen.
Potassium Alkoxide as an Efficient Catalyst for Nucleophilic Perfluoroalkylation: Attempt at Anion-Controlled Enantioselective Insertion of a Trifluoromethyl Group
Authors: Yurino Taiga , Ohkuma Takeshi , Yamashita Hiroyuki , Shan Yuanrong , Wu Zhen 
Published: August 2022

AbstractPotassium alkoxide was found to be a highly active catalyst for the nucleophilic trifluoromethylation of carbonyl compounds. The catalytic system was successfully applied to the reactions of both aldehydes and ketones, affording the corresponding trifluoromethylated products in high yields at low catalyst loadings (0.1–0.01 mol%) in several solvents, such as THF, toluene, and CH2Cl2. In addition, the potassium salt of a Ru(II) complex bearing an (S)-2,2′-bis[bis(3,5-dimethylphenyl)phosphinyl]-1,1′-binaphthalene [(S)-XylBINAP] ligand and two l-threoninate ligands, prepared in situ, catalyzed the enantioselective trifluoromethylation of aromatic aldehydes, although the ee values were not satisfactory (less than 20%).
Photoinduced Tandem Cyclization of Alkynes with Phenylsulfinic Acids: Access to Sulfone-Substituted Dioxodibenzothiazepines or Dibenzazepines
Authors: Li Lijun , Liu Zhong-Quan , Li Zejiang , Chen Shiliu , Yan Qinqin , Fan Jie 
Published: August 2022

AbstractPhotoinduced tandem cyclization of alkynes with phenylsulfinic acids has been accomplished, which gives a mild strategy for the preparation of sulfone-substituted seven-membered N-heterocycles. A variety of scaled-up experiments, further transformations, and mechanistic studies were also operated in the follow-up work.
The Leipzig Health Atlas—An Open Platform to Present, Archive, and Share Biomedical Data, Analyses, and Models Online
Authors: Kirsten Toralf , Meineke Frank A. , Loeffler-Wirth Henry , Beger Christoph , Uciteli Alexandr , Stäubert Sebastian , Löbe Matthias , Hänsel René , Rauscher Franziska G. , Schuster Judith , Peschel Thomas , Herre Heinrich , Wagner Jonas , Zachariae Silke , Engel Christoph , Scholz Markus , Rahm Erhard , Binder Hans , Loeffler Markus ,   on behalf of the LHA team
Published: August 2022

Abstract
Background Clinical trials, epidemiological studies, clinical registries, and other prospective research projects, together with patient care services, are main sources of data in the medical research domain. They serve often as a basis for secondary research in evidence-based medicine, prediction models for disease, and its progression. This data are often neither sufficiently described nor accessible. Related models are often not accessible as a functional program tool for interested users from the health care and biomedical domains.
Objective The interdisciplinary project Leipzig Health Atlas (LHA) was developed to close this gap. LHA is an online platform that serves as a sustainable archive providing medical data, metadata, models, and novel phenotypes from clinical trials, epidemiological studies, and other medical research projects.
Methods Data, models, and phenotypes are described by semantically rich metadata. The platform prefers to share data and models presented in original publications but is also open for nonpublished data. LHA provides and associates unique permanent identifiers for each dataset and model. Hence, the platform can be used to share prepared, quality-assured datasets and models while they are referenced in publications. All managed data, models, and phenotypes in LHA follow the FAIR principles, with public availability or restricted access for specific user groups.
Results The LHA platform is in productive mode (https://www.health-atlas.de/). It is already used by a variety of clinical trial and research groups and is becoming increasingly popular also in the biomedical community. LHA is an integral part of the forthcoming initiative building a national research data infrastructure for health in Germany.
Der Intraokulardruck nach Netzhauteingriffen
Authors: Weber Constance , Liegl Raffael , Mercieca Karl 
Published: August 2022

ZusammenfassungNetzhauteingriffe können zu einem erhöhten Augeninnendruck führen. Die Ursachen hierfür sind vielfältig und schließen mechanische, aber auch pharmakologische Gründe ein. Die Therapie
besteht zunächst aus einer Lokaltherapie mit drucksenkenden Augentropfen. Bei unzureichendem Ansprechen sind chirurgische Eingriffe indiziert.
Recent Advances in the Generation of Onium Ylides for Sommelet–Hauser Rearrangements
Authors: Tayama Eiji 
Published: August 2022

AbstractThe Sommelet–Hauser rearrangement of X-benzylic onium ylides (X = heteroatom) is an interesting transformation in organic synthesis. This rearrangement proceeds via dearomative [2,3]-sigmatropic rearrangement, followed by aromatization to form a carbon(sp2)–carbon(sp3) bond. Few advances were made in studies performed around 2000 on this rearrangement because of several competitive side reactions and structural limitations. However, studies performed in the last 15 years on the rearrangement have remarkably expanded the substrate scope and synthetic applications. In this review, the utility of the Sommelet–Hauser rearrangement and recent advances for the generation of onium ylides are described.1	Introduction2	Base-Induced Rearrangement3	Transition-Metal-Catalyzed Rearrangement4	Light-Mediated Rearrangement5	Aryne-Induced Rearrangement6	Conclusions and Outlook
Wet-suction versus slow-pull technique for endoscopic ultrasound-guided fine-needle biopsy: a multicenter, randomized, crossover trial
Authors: Crinò Stefano Francesco , Conti Bellocchi Maria Cristina , Di Mitri Roberto , Inzani Frediano , Rimbaș Mihai , Lisotti Andrea , Manfredi Guido , Teoh Anthony Y. B. , Mangiavillano Benedetto , Sendino Oriol , Bernardoni Laura , Manfrin Erminia , Scimeca Daniela , Unti Elettra , Carlino Angela , Voiosu Theodor , Mateescu R. Bogdan , Fusaroli Pietro , Lega Stefania , Buscarini Elisabetta , Pergola Lorena , Chan Shannon M. , Lamonaca Laura , Ginès Àngels , Fernández-Esparrach Gloria , Facciorusso Antonio , Larghi Alberto 
Published: August 2022

Background It is unknown whether there is an advantage to using the wet-suction or slow-pull technique during endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) with new-generation needles. We aimed to compare the performance of each technique in EUS-FNB.
Methods This was a multicenter, randomized, single-blind, crossover trial including patients with solid lesions of ≥ 1 cm. Four needle passes with 22 G fork-tip or Franseen-type needles were performed, alternating the wet-suction and slow-pull techniques in a randomized order. The primary outcome was the histological yield (samples containing an intact piece of tissue of at least 550 μm). Secondary end points were sample quality (tissue integrity and blood contamination), diagnostic accuracy, and adequate tumor fraction.
Results Overall, 210 patients with 146 pancreatic and 64 nonpancreatic lesions were analyzed. A tissue core was retrieved in 150 (71.4 %) and 129 (61.4 %) cases using the wet-suction and the slow-pull techniques, respectively (P = 0.03). The mean tissue integrity score was higher using wet suction (P = 0.02), as was the blood contamination of samples (P < 0.001). In the two subgroups of pancreatic and nonpancreatic lesions, tissue core rate and tissue integrity score were not statistically different using the two techniques, but blood contamination was higher with wet suction. Diagnostic accuracy and tumor fraction did not differ between the two techniques.
Conclusion Overall, the wet-suction technique in EUS-FNB resulted in a higher tissue core procurement rate compared with the slow-pull method. Diagnostic accuracy and the rate of samples with adequate tumor fraction were similar between the two techniques.
Iron-Catalyzed Benzene Ring Expansion of α-Azido-N-phenylamides
Authors: Wei Kaijie , Jiang Menglu , Yu Wei , Liang Siyu 
Published: August 2022

AbstractNitrenoid-mediated C–H insertion and cycloaddition reactions are gaining increasing importance in modern organic synthesis. However, the nitrene-mediated benzene ring expansion, which constitutes a potent tool for breaking the benzene ring, has sparely been explored for synthetic purposes. Herein we report that nitrene cycloaddition to the benzene ring can be enabled intramolecularly by iron catalysis. By using FeCl2 and N-heterocyclic carbene SIPr·HCl as the catalyst, α-azido-N-phenylamides can be converted into 1,3-dihydro-2H-azepin-2-ones in good yields through a novel skeleton rearrangement. The rearrangement features a cascade of nitrene cycloaddition, C–N cleavage, water addition, and electrocyclic ring-opening. In the case that the N-phenyl ring is substituted with a methoxy group at the meta or para position, azepin-2-one-fused imidazolinones can also be obtained. The present reactions provide an effective method for benzene ring expansion as well as for the preparation of azepin-2-one compounds.
Stereoselective Pd-Catalyzed Remote Hydroamination of Skipped Dienes with Azoles
Authors: Li Jian , Lin Guo-Qiang , He Zhi-Tao , Miao Han-Zhe , Liu Yang , Chen Ye-Wei , Lu Han-Yu 
Published: August 2022

AbstractA novel palladium-catalyzed stereoselective remote ­hydroamination reaction is disclosed. A series of azoles and skipped dienes undergo the migratory allylic C–H amination in good yields and selectivities. A desymmetric migratory azolation process is also developed to highlight the reliability of the transformation. Preliminary mechanistic experiments corroborate the designed metal walking and allylic substitution cascade strategy via Pd–H catalysis, different from prior ligand-to-ligand hydrogen transfer pathway for conjugated dienes.
Asymmetric Synthesis of ent-Anorisol A and Its Stereoisomers and Confirmation of the Absolute Configuration of Anorisol A Isolated from Anogeissus rivularis
Authors: Soorukram Darunee , Chatpreecha Rungrawin , Kuhakarn Chutima , Leowanawat Pawaret , Reutrakul Vichai 
Published: August 2022

AbstractAsymmetric synthesis of (2S,3S,4R,5S)-2-(2,4-dihydroxyphenyl)-5-(4-methoxyphenyl)-3,4-dimethyltetrahydrofuran, named as ent-anorisol A, was accomplished. The uncommon relative 2,3-anti-3,4-syn-4,5-syn stereochemistry across the tetrahydrofuran ring of ent-anorisol A was constructed with high yield and good stereoselectivity via an acid-catalyzed direct cyclization of unprotected chiral 1,4-diarylbutane-1,4-diol with non-symmetrical aromatic rings. Except for the sign of the specific rotation value, the spectroscopic data of the synthetic ent-anorisol A are in good agreement with those reported for natural anorisol A isolated from Anogeissus rivularis. In addition, the (2R,3S,4R,5R) and (2S,3S,4R,5R) isomers of anorisol A were also synthesized. Comparison of the specific rotation value and the experimental electronic circular dichroism data of natural anorisol A with those of the synthesized ent-anorisol A, (2R,3S,4R,5R), and (2S,3S,4R,5R) derivatives confirms the 2R,3R,4S,5R configurations assigned for natural anorisol A.
Immobilization of Functionalized epi-Cinchonine Organocatalysts on Controlled Porous Glass Beads: Applications in Batch and ­Continuous Flow
Authors: Burke Anthony J. , Amorim Ana C. , Fonseca Daniela P. , Carreiro Elisabete P. , Hermann Gesine J. , Federsel Hans-Jürgen 
Published: August 2022

AbstractA well-known squaramide-cinchonine organocatalyst was immobilized in a controlled way onto three types of commercial porous glass beads EziG™ (EziG OPAL, EziG Amber, and EziG Coral) and applied in asymmetric Michael reactions. The performance of the immobilized catalysts was evaluated under batch and continuous-flow conditions, showing promising results in both approaches. In batch reactions, 0.8 and 1.6 mol% of the immobilized cinchonine-squaramide provided the products with excellent yields (up to 99%) and enantioselectivities (up to 99% ee). These excellent results were also verified in the case of continuous-flow reactions, where also 0.8 and 1.6 mol% of the catalyst immobilized onto the glass beads afforded the product with extraordinary yields (up to 99%) and very high enantioselectivities (up to 97% ee). The immobilized catalysts could be recycled (up to seven cycles) using both approaches.
Direct Methenylation of 4-Alkylpyridines Using Eschenmoser’s Salt
Authors: Pigge F. Christopher , Shivers Grant N. , Tun Soe L. , McLean Shay L. 
Published: August 2022

Abstract4-Alkylpyridines are converted into conjugated 1,1-disubstituted alkenyl pyridines (vinyl pyridines) upon treatment with excess ethyl chloroformate, triethylamine, and Eschenmoser’s salt. The reaction proceeds under mild conditions via alkylidene dihydropyridine intermediates.
A Novel Variant of the Short-Chain Enoyl-CoA Hydratase-1 Gene Presenting with a Mild Phenotype: The Second Case Report from India
Authors: Das Suman , Ray Biman K. , Chakraborty Uddalak , Kabiraj Sujoy 
Published: August 2022

AbstractA 9-year-old girl presented with asymmetric abnormal twisting movements affecting her left side more than the right side, initially action induced, but later persistent. Examination revealed generalized persistent dystonia with choreoathetosis and right partial tonic ocular tilt reaction. Brain magnetic resonance imaging showed T1 and T2 fluid-attenuated inversion recovery (FLAIR) hypointense and T2 hyperintense signal changes in bilateral globus pallidi. Clinical exome sequencing revealed compound heterozygous variatnts in enoyl-CoA hydratase-1 (ECHS1) gene: a novel pathogenic variant in exon 6, chr10:g.133366045G > A (p.Gln224Ter) and a likely pathogenic variant in exon 5, chr10:g.133366990G > A (p.Ala173Val). Metabolic testing and arterial lactate levels were normal. She was treated with valine restricted diet, trihexiphenidyl, clonazepam, N-acetyl cysteine and mitochondrial cocktail, without significant improvement over the 6 months follow-up period.
Synthesis of Nitrogen Heterocycles by a C–C Cross-Coupling/Cycloisomerization Strategy
Authors: Langer Peter 
Published: August 2022

AbstractThe present article presents a personalized Account on the synthesis of nitrogen heterocycles by combination of regioselective Pd-catalyzed cross-coupling reactions of polyhalogenated heterocycles, i.e., Suzuki–Miyaura and Sonogashira reactions, with acid-mediated cycloisomerization reactions. In many cases, the products constitute new heterocyclic core structures and show interesting optical and electronic properties.1	Introduction2	Acridines3	Phenathridines4	Azapyrenes5	Thienoquinolines6	Pyrrolonaphthyridines7	6-Aza-ullazines8	Conclusions
Expanding the absorption and photoresponse of 1D lead–halide perovskites via ultrafast charge transfer
Authors: Chen Zhongwei , Liu Yang , Gong Shaokuan , Zhang Zixuan , Cao Qinxuan , Mao Lingling , Chen Xihan , Lu Haipeng 
Published: August 2022

Low-dimensional metal halide perovskites are attracting extensive attention due to their enhanced quantum confinement and stability compared to three-dimensional perovskites. However, low dimensional connectivity in the inorganic frameworks leads to strongly bounded excitons with limited absorption properties, which impedes their application in photovoltaic devices. Here, we show that, by incorporating a strong electron accepting methylviologen cation, charge transfer (CT) at the organic/inorganic interface can effectively tune the optical properties in one-dimensional (1D) lead–halide perovskites. Both 1D MVPb2I6 and MVPb2Br6 display expanded absorption and photoresponse activity compared to CT inactive cations. The photoinduced CT process in MVPb2I6 was further characterized by transient absorption spectroscopy, which shows an ultrafast CT process within 1 ps, generating charge separated states. Our work unveils the interesting photophysics of these unconventional 1D perovskites with functional organic chromophores.
Perspective: New directions in dynamical density functional theory
Authors: te Vrugt Michael , Wittkowski Raphael 
Published: August 2022

Abstract
Classical dynamical density functional theory (DDFT) has become one of the central modeling approaches in nonequilibrium soft matter physics. Recent years have seen the emergence of novel and interesting fields of application for DDFT. In particular, there has been a remarkable growth in the amount of work related to chemistry. Moreover, DDFT has stimulated research on other theories such as phase field crystal models and power functional theory. In this perspective, we summarize the latest developments in the field of DDFT and discuss a variety of possible directions for future research.