bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Arg753Gln (rs574308) polymorphism of the Toll-like receptor 2 (TLR2) gene and the risk of pulmonary sarcoidosis among the residents of Karelia”
Authors: Malysheva I. E. , Topchieva L. V. , Tikhonovich E. L. 
Published: July 2022

Genetic factors play an important role in the development and progression of many disorders including lung sarcoidosis which is a systemic inflammatory granulomatous disease of unknown etiology, characterized by the formation of epithelioid cell granules in affected tissues. Intensity of the developing inflammation may partially depend on genetic factors which may influence both susceptibility to lung sarcoidosis, and also clinical course of the disease and the degree of inflammatory response from the immune system. Allelic polymorphism of distinct genes is therefore worth of study. In the carriers of certain allele variants, one may observe either increase, or a decreased production of pro-inflammatory factors. Among the candidate factors involved in higher susceptibility of humans, one may consider Toll-like receptors (TLRS) which may contribute to formation of granulomas. Relevant data concerning association between the allele variants of these genes and susceptibility to lung sarcoidosis, and its clinical course are still quite limited and contradictory. The aim of the present study was to analyze the association between the Arg753Gln (rs574308) polymorphism of the Toll-like receptor 2 (TLR2) gene and the risk of developing pulmonary sarcoidosis.A total of 253 persons were under study including 122 patients diagnosed with morphologically verified sarcoidosis with lung involvement (average age, 41.00±12.56 years), and 131 healthy donors comprising a control group (average age, 44.00±14.23 years). The distribution of alleles and genotypes for the Arg753Gln (rs574308) polymorphic TLR2 gene marker was studied in the groups of patients with pulmonary sarcoidosis and healthy donors. The test alleles of this polymorphic marker were typed by means of PCR technique followed by length analysis restriction fragments (PCR-RFLP method).There were no statistically significant differences in the distribution of allele and genotype frequencies for the polymorphic marker Arg753Gln (rs574308) of the TLR2 gene between the control group and the group of patients with pulmonary sarcoidosis: χ2 = 2.0, df = 1, p = 0.158 and χ2 = 2.19, df = 2, p = 0.140, respectively.The polymorphic marker Arg753Gln (rs574308) of Toll-like receptor 2 gene is not associated with the risk of developing pulmonary sarcoidosis among ethnic Russians of the Republic of Karelia.
SNP genes of immune response mediators and predisposition to development of socially significant diseases
Authors: Tatarkova E. A. , Tuguz A. R. , Shumilov D. S. , Muzhenya D. V. , Rudenko K. A. , Smolkov I. V. 
Published: July 2022

Allele typing of single-nucleotide polymorphisms (SNPs) may be used in predictive medicine and to determine targets for the most effective treatment strategies for various diseases. The purpose of the present work was to investigate the association between the SNPs of inflammatory genes, e.g., IL10 (C819T; rs1800871; C592A; rs1800872); IL4 (C589T; rs2243250); fibrosis-related factors - TGFβ1 (G915C; rs1800471); MMP1 (1607insG; rs1799750); apoptosis-regulators (TNFRSF11B G1181C; rs2073618); vasoconstricting factors (CRP C3872T; rs1205); CYP1A1 (A2454G; rs1048943), endothelial dysfunction (EDN1 G925T; rs5370); (NOS3 C786T; rs2070744) and development of coronary heart disorders, breast cancer, bronchial asthma (BA) and threatened miscarriage in early pregnancy among population of the Republic of Adygea.DNA samples of unrelated donors and patients (n = 74) with verified diagnoses of bronchial asthma (n = 13), coronary heart disease (n = 10), breast cancer (n = 10) and threatened miscarriage in the first trimester of pregnancy (n = 8) were isolated from peripheral blood leukocytes and typed by allele-specific polymerase chain reaction with electrophoretic detection of results using commercial tests-systems of NPF “Litech”, Moscow.The study in a group of Adygea residents has revealed the statistical significance for the “normal” Arg25-allelic variant of the TGFβ1 gene (p < 0.05; F = 0.038; OR = 3.231; 95% CI = 1.081-9.656) in the development of bronchial asthma. There were no significant differences in SNP rs1800471 of the TGFβ1 gene in the groups with cardiovascular, oncological diseases and gestational disorders (p > 0.05). The frequency distribution of allelic variants NOS3 C786T; TNFRSF11B G1181C; 1607insG of the MMP1 gene; G925T of the EDN1 gene, and CYP1A1 2454G in the examined patients with cardiovascular disease and breast cancer did not significantly differ from the control group (p > 0.05). The statistical significance for the frequency of allelic variants rs1799750 (MMP1 gene) in cases of threatened early miscarriage and in women with a physiological course of pregnancy (F = 0.096; p < 0.05%: OR = 6.0) was close to reliable, but with a confidence interval > 1.0 (95% CI = 0,98036,716), thus requiring further research.The obtained data could be sufficient in order to suggest predisposition for bronchial asthma, as well as to develop a set of preventive measures taking into account the individual characteristics of each patient.
Epilepsy management during difficult times
Authors: Mesraoua Boulenouar , Cross J. Helen , Perucca Emilio , Asadi‐Pooya Ali A. 
Published: July 2022

AbstractMajor disruption in the delivery of healthcare services can occur in exceptional situations such as natural disasters, conflicts, periods of severe economic hardship, and epidemics. These disruptions typically affect to the greatest extent the most vulnerable segments of the population, including people with epilepsy. Inability to access healthcare services can lead to failure to undergo necessary diagnostic investigations, or to receive needed therapeutic interventions, including epilepsy surgery. Stress and other factors associated with the nature or the cause of the disruption can adversely affect seizure control status, or precipitate the occurrence of psychiatric disorders and other comorbid conditions. Failure to access antiseizure medications is a common occurrence in these situations and can result in loss of seizure control, withdrawal seizures, and status epilepticus. In this article, we provide examples of recent disruptions in healthcare and their implications for people with epilepsy. We discuss the consequences of natural disasters, conflicts, economic sanctions, and focus in greater detail on lessons learnt during the COVID‐19 pandemic. We also discuss possible mitigation procedures, focusing in particular on the application of telemedicine to epilepsy care. Finally, we underline the need for governments, healthcare authorities, and international organizations to improve their preparedness to deal with exceptional situations that may arise in the future.
“Temporal” intermittent rhythmic delta activity: the true localizing nature of TIRDA
Authors: Freund Brin E. , Mheir‐Al‐Saadi Zuha , Brinkmann Benjamin H. , Tatum William O. 
Published: July 2022

AbstractTemporal lobe epilepsy is the most common form of focal epilepsy and is frequently resistant to antiseizure medication. Non‐invasive biomarkers are crucial when resective epilepsy surgery is considered in order to guide diagnostic work‐up and management. Interictal epileptiform discharges, when concordant with ictal EEG recording and a focal abnormality on functional imaging or anatomic MRI in patients with temporal lobe epilepsy, portend a favorable outcome with resective or ablative surgery. An interictal nonepileptiform feature on EEG believed to have the same localizing potential as epileptiform discharges is temporal intermittent rhythmic delta activity (TIRDA). The precise localization of TIRDA has been a subject of debate, but has been associated with seizures that arise from the temporal region. We report a 64‐year‐old female who underwent unsuccessful right anterior temporal lobectomy for drug‐resistant focal epilepsy, suspected to originate from the right temporal lobe. Subsequent video‐EEG monitoring revealed right, greater than left, TIRDA and interictal epileptiform discharges arising from the temporal regions bilaterally, despite a generous temporal lobectomy demonstrated by brain MRI. Further, using EEG source localization, we identified TIRDA using scalp EEG in sensor space, localized to the ipsilateral orbitofrontal region. We discuss the proposed localization of TIRDA in this case and address the importance of characterizing TIRDA in the presurgical evaluation of patients with epilepsy.
Descripción de defectos de superficie y micro-dureza en estructuras de cobalto cromo para prótesis dentales realizadas mediante la técnica CAD-CAM
Authors: Mosquera Palomino Josefina , Vélez Gómez Carlos Ignacio 
Published: July 2022

Objetivo: describir los defectos de superficie y micro dureza en estructuras de cobalto cromo para prótesis dentales realizadas mediante la técnica CAD-CAM. Método: Tipo de estudio descriptivo. Población y muestra: 10 estructuras en aleación cobalto cromo para prótesis dentales tipo barra de 3 piezas, dimensiones 10 cm x 1.5cm. De una impresión convencional se obtuvo el modelo de yeso, se realizó la preparación del modelo para escaneado y diseño de la estructura, luego se mandó a fresar la estructura bajo la supervisión de los investigadores del proyecto. Posteriormente fueron analizadas en el microscopio electrónico de barrido y en el equipo en el equipo Shimadzu Micro Vickers Hardness Tester HMV-G 21. Resultados: a través de la microscopia electrónica de barrido se obtuvieron imágenes con aumentos de varios tamaños donde se observan diferentes defectos de superficie como irregularidades superficiales, suciedad y cuerpos extraños. Se encuentra que las muestras fresadas con tres ejes tienen una dureza de 294,6 ± 21 HK0,1 y un módulo elástico de 239 ± 22.3 GPa, mientras que las muestras fresadas con cinco ejes tienen una dureza de 336,2 ± 20,9 HK0,1 y un módulo elástico de 237.7 ± 18.3 GPa. Conclusiones: a través de la microscopia electrónica de barrido se observaron defectos de superficie que a simple vista no se ven como son irregularidades superficiales, desniveles y suciedad principalmente grasa por el alto contenido de carbono. Sin embargo, no se observan grietas y porosidades. El fresado tiene una ligera influencia en la dureza, pero no en el módulo elástico de la aleación.
Anticonceptivos orales como factor asociado a los adenomas hipofisarios: Revisión sistemática/meta-análisis.
Authors: Vargas Rodríguez Ledmar J. , Fonseca Leidy , Vergara López Sofía Alejandra , Mesa Espinal Mario Santiago 
Published: July 2022

Antecedentes: Los adenomas hipofisarios son neoplasias que aparecen en la silla turca, los cuales muestran una amplia gama de comportamientos hormonales y proliferativos, con una tasa de crecimiento lenta. Tanto los estrógenos como las progestinas presentes en los anticonceptivos orales suelen estimular las células lactotropas pituitarias, lo cual puede facilitar la aparición de hiperprolactinemia, junto con hipertrofia e hiperplasia de estas células y causar el desarrollo de tumores pituitarios.
Objetivo: Establecer la asociación entre el uso de anticonceptivos orales y el desarrollo de adenomas hipofisarios en mujeres mayores de 18 años.
Materiales y métodos: Se realizó una revisión sistemática de literatura. Las búsquedas fueron realizadas por tres investigadores, usando las bases de datos de Pubmed/Medline, Science direct, Scopus, Embase, Cochrane Library, BIREME, Redalyc, Scielo y el Directory of Open Access Journals (DOAJ).
Resultados: Se incluyeron 3 estudios (573 casos y 794 controles). El forest plot de resultados finales evidenció que el uso de anticonceptivos orales no se asocia con la presencia o aparición de adenomas hipofisiarios (OR 0,89 (IC 95% 0.60 – 1.33).
Conclusiones: No hay asociación entre el uso de anticonceptivos orales y el desarrollo de adenomas hipofisiarios en mujeres mayores de 18 años.
Teacher in an Inclusive Classroom: Relationship between Attitudes towards Inclusive Education and Job Satisfaction
Authors: Volosnikova Ludmila , Ignatjeva Svetlana , Fedina Ludmila , Bruk Zhanna 
Published: July 2022

Inclusive education as education, as the right to co-educate children with special educational needs in the regular classroom, is a global framework for the transformation of general education systems. At the same time, critical studies show that the degree of real inclusion of schools is increasing slowly. The objectives of this study were factors that determine the teacher’s attitude to inclusive education.The article presents an analysis of teacher’s job satisfaction and its relationship with attitudes towards inclusive education. The empirical base of the study was data obtained from a survey of 119 school teachers in the city of Tyumen. The study of attitudes towards inclusive education and satisfaction with work of teachers was carried out using the author’s questionnaire. With the help of factor analysis, three factors of the teachers’ attitude to inclusive education were identified: teachers see inclusion as a pedagogical resource (24.8% of the total variance); problems (23.8%); risks (14.1%). Cluster analysis made it possible to identify homogeneous groups of teachers who have their own dominants in relation to inclusion: romantics, realists and critics. A four-factor structure of job satisfaction was also found: safety and security, organization of the work process, satisfaction with remuneration, involvement in work. It has been established that teachers rate the factor “safety and security” in their work the lowest. Cluster analysis made it possible to identify three groups of teachers: satisfied with their work; satisfied with remuneration for work; not satisfied with work. The most vulnerable are teachers who fall into the third cluster group: due to the low assessment of satisfaction with all factors, they will be inclined to assess inclusion from the standpoint of problems and barriers. Correlation analysis established direct statistically significant relationships between teachers’ assessment of inclusion as a pedagogical resource and job satisfaction; the strongest relationship can be traced in the assessment with the indicator “satisfaction with the organization of the work process”.
Bimbingan Teknis Implementasi Kurikulum 2013 Dalam Publikasi Ilmiah Berbasis Karakter untuk Meningkatkan Kompetensi Profesional Guru Sekolah Dasar
Authors: Zainuddin Mohammad , Sutansi Sutansi , Cholifah Puri Selfi , Fatih Mohamad , Fauzi Achmad Ryan 
Published: July 2022

This Community Service Program is aimed at elementary school teachers in Blitar, scientific works in the form of PTK and scientific publications as a condition for improving the Kingdom, especially SDI Garum (Mitra 1) and MI Hidayatullah (Mitra 2), where both experienced failures in applying for a teacher profession. The guidance implementation is divided into two sessions. Partnership stages carried out for Partner I are: (1) conducting training related to the urgency, components, and tips for preparing CAR, (2) providing assignments and assistance for the preparation of CAR, and (3) assistance in conducting seminars on the results of PTK. conducted for Partner II, namely: (1) conducting training related to urgency and tips in conducting scientific publications, (2) assistance in the preparation of scientific articles, and (3) assistance in publishing in scientific journals. The service has been carried out smoothly for 3 days. The first day of giving material (face to face), the second and third days are assignments. In this assignment, participants have produced the expected product. Thus, a conclusion can be drawn that the implementation of this service has succeeded in improving the ability of teachers to write scientific papers. So that the provisions they have can increase the professional competence of teachers.Program Pengabdian Masyarakat ini ditujukan kepada guru-guru SD di Blitar karya ilmiah berupa PTK dan publikasi ilmiah sebagai syarat peningkatan Raya khususnyaSDI Garum (Mitra 1) dan MI Hidayatullah (Mitra 2), dimana keduanya mengalami kegagalan dalam mengajukan profesi (jabatan) guru. Pelaksanaan bimbingan terbagi menjadi dua sesi. Tahapan kemitraan yang dilakukan untuk Mitra I yaitu: (1) melakukan pelatihan terkait urgensi, komponen, dan kiat-kiat penyusunan PTK, (2) memberikan penugasan dan pendampingan penyusunan PTK, dan (3) pendampingan dalam melakukan seminar hasil PTK. Sedangkan tahapan kemitraan yang dilakukan untuk Mitra II yaitu: (1) melakukan pelatihan terkait urgensi dan kiat dalam melakukan publikasi ilmiah, (2) pendampingan penyusunan artikel ilmiah, dan (3) pendampingan dalam melakukan publikasi di jurnal ilmiah. Pengabdian telah dilaksankan dengan lancar selama 3 hari.Hari pertama pemberian materi (tatap muka), hari kedua dan ketiga merupakan penugasan. Pada penugasan ini, peserta telah menghasilkan produk yang diharapkan.Dengan demikian dapta diambil suatu kesimpulan bahwa pelaksanan pengabdian ini telah berhasil meningkatkan kemampuan guru dalam menulis karya ilmiah.Sehingga denagn bekal yang telah dimiliki ini dapat meningkatkan kompetensi professional guru-guru.
Pemberdayaan Pendidik Pada Sekolah Laboratorium Universitas Negeri Malang untuk Menulis Karya Ilmiah Berbasis PTK
Authors: Nurabadi Ahmad , Bafadal Ibrahim , Sobri Ahmad Yusuf , Gunawan Imam 
Published: July 2022

The problem faced by teachers and principals in the UM laboratory school environment is that teachers do not understand how to carry out research, especially action research. Teachers still feel they need guidance and guidance in terms of: carrying out research and in writing research reports and writing scientific journals. The output of this activity seeks to increase understanding to 40 teachers and school principals about: a) preparation of scientific paper proposals, b) Classroom Action Research (CAR) methodology, c) writing action research research reports c) good scientific article writing techniques. The methods used in this activity are: a) workshops, and b) intensive guidance. The result of this activity is that this community service activity can be successful. To solidify the results, the next step is to assign participants the task of implementing and disseminating the results of training and workshops in their respective schools. To see the implementation, an outcome evaluation was also carried out by the service team at several schools that were the target of service activities. Based on the evaluation results, most of the teachers have implemented the results of training and workshop. Permasalahan yang dihadapi oleh guru dan kepala sekolah di lingkungan sekolah laboratorium UM adalah guru kurang memahami bagaimana melaksanakan penelitian terutama action research. Guru-guru masih merasa memerlukan pembinaan dan pembimbingan dalam hal: melaksanakan research dan dalam penulisan laporan hasil penelitian serta penulisan jurnal ilmiahnya. Luaran kegiatan ini berupaya meningkatkan pemahaman kepada 40 orang guru dan kepala sekolah tentang: a) penyusunan proposal karya ilmiah, b) metodologi Penelitian Tindakan Kelas (PTK), c) penulisan laporan hasil penelitian action research c) tata cara teknik penulisan artikel ilmiah yang baik. Metode yang digunakan dalam kegiatan ini adalah: a) workshop, dan b) bimbingan intensif. Hasil dari kegiatan ini adalah bahwa kegiatan pengabdian kepada masyarakat ini dapat berhasil dengan baik. Untuk memantapkan hasil, tahap selanjutnya diberikan tugas kepada peserta untuk menerapkan dan melakukan desiminasi hasil pelatihan dan workshop di sekolah masing-masing. Untuk melihat implimentasinya, juga dilakukan evaluasi outcome yang dilakukan tim pengabdian pada beberapa sekolah yang menjadi sasaran kegitan pengabdian. Berdasarkan hasil evaluasi, sebagain besar guru telah menerapkan hasil pelatihan dan workshop.
Meningkatkan Kesadaran Masyarakat Mematuhi Protokol Kesehatan sebagai Upaya Pencegahan Covid-19
Authors: Kurniati Astiwi , Ardiyanza Bima , Wijaya Bandel Ari , Ilham Muhammad , A Oktavia L 
Published: July 2022

Community service activities integrated in Pletukan Hamlet, Sidoagung Village, Tempuran District, Magelang District. This program helps people to raise awareness of healthy living by washing their hands using soap and running water, wearing masks when doing activities outside the home, not touching and keeping a distance when in public places, and wearing a handsanitizer. The application of this activity is to follow the government's recommendations to avoid the Covid-19 virus. The method used in this activity is the socialization of accurate ways to avoid Covid-19 and the distribution of masks. The community feels helped by the socialization because it can increase knowledge about personal health and environmental hygiene, and to comply with health protocols. Kegiatan pengabdian pada masyarakat terpadu di Dusun Pletukan, Desa Sidoagung, Kecamatan Tempuran, Kabupaten Magelang. Program ini membantu masyarakat untuk meningkatkan kesadaran hidup sehat dengan mencuci tangan menggunakan sabun dan air mengalir, memakai masker jika beraktivitas di luar rumah, jangan bersentuhan dan jaga jarak saat di tempat umum, serta memakai handsanitizer. Penerapan kegiatan ini adalah mengikuti anjuran pemerintah supaya terhindar dari virus Covid-19. Metode yang digunakan pada kegiatan ini adalah sosialisasi tentang cara jitu terhindar dari Covid-19 dan pembagian masker. Masyarakat merasa terbantu dengan adanya sosialisasi tersebut karena dapat meningkatnya pengetahuan mengenai kesehatan diri dan kebersihan lingkungan, serta supaya mematuhi protocol kesehatan.
Knowledge, attitudes and practice among high school teachers toward students with mental disorders in Riyadh, Saudi Arabia
Authors: Alshammari Sulaiman A. , Alenezi Shuliweeh , Alanzan Abdullah , AlHawamdeh Ahmed , Alsulaiman Omar , Alqarni Nawaf , Aldraihem Saad , Alsunbul Nasser 
Published: July 2022

Background: Mental disorders are highly prevalent among adolescents, and they correlate negatively with students’ achievement, performance, and leadless school engagement and participation. School Teachers can contribute significantly to the early detection and intervention strategies for mental disorders among adolescents. This study estimates high school teachers’ knowledge, attitude, and practice toward mental disorders and determines the association between selected demographic factors.Methods: The ethical committee of King Saud University, Riyadh, Saudi Arabia, approved this cross-sectional study. Multistage random sampling was done, which included 62 male and 48 female high schools in Riyadh between August and December 2021. An Anonymous self-administered questionnaire consisting of 39-item was used for data collection.Results: A total 487 responses were received from the high school teachers, on a scale of 10 maximum score, only (60.4%) showed adequate knowledge regarding mental disorders. Even though, Majority of teachers (76.2%) show a favorable attitude toward mental disorders on a scale of 24 maximum scores. Furthermore, approximately one-third of study participants (34.4%) on a scale of 4 points maximum show good practice toward mental disorders. Conclusions: This study revealed teachers’ lack of knowledge about mental disorders with poor practice. Even though school teachers have shown favourable attitudes in most aspects toward mental disorders, implantation of the mental health literacy program is recommended to enhance the essential role of school staff in providing the needed support for promoting student mental health.