bluuebunny/crossref_metadata_2025_split huggingface dataset:
Petrogenesis of mafic-intermediate magmatism of the Michoacán–Guanajuato volcanic field in Western Mexico. A geochemical review
Authors: Torres-Sánchez Darío , Sosa-Ceballos Giovanni , Bolós Xavier , Macías José Luis 
Published: September 2022

The Michoacán–Guanajuato volcanic field (MGVF) in the western Trans-Mexican Volcanic Belt is one of the largest and most diverse monogenetic volcanic fields in the world holding more than 1200 volcanic vents. Its eruptive activity goes back to 7 Ma, it is considered an active volcanic field, and the composition of its rocks varies from mafic to silicic. It is essential to understand the geochemical evolution of its products, the complex petrogenetic processes, and the origin of magmas in central Mexico. Although these processes are linked to the subduction of the Cocos plate beneath the North American plate, the magmatic plumbing system of the MGVF remains not completely understood. The MGVF has been studied for decades, focusing in its dominant intermediate magmas. Nevertheless, the origin and evolution of the mafic components and their relation with the intermediate rocks have been poorly discussed. Here, we compile geological and geochemical data of the MGVF to discuss the petrogenesis of mafic magmas along the volcanic field and the role they play in the generation of intermediate melts. We used data published for 429 samples of mafic and intermediate volcanic rocks. Conventional procedures and statistical techniques were used to process the dataset. We propose that MGVF mafic magmas are derived from low degrees (∼1–15%) of partial melting of a spinel-bearing lherzolite source/mantle related to the rapid ascent of the asthenosphere caused by an extensional regime that is present in the area. In contrast, intermediate magmas where divided into two main groups based on the Mg content: high-Mg intermediate rocks, which seems to be derived from different rates of assimilation and fractional crystallization process, and low-Mg intermediate rocks, which can be related to fractional crystallization of mafic magmas. In addition, mafic and intermediate magmas display a chemical diversity which is related to mantle heterogeneity domains in the mantle wedge.
Possible reasons for the migration of tropical cyclone track over the western north pacific: Interdecadal pacific oscillation modulation
Authors: Lv Shuo , Sun Yuan , Zhong Zhong , Shen Yixuan 
Published: September 2022

Recent studies have proposed a relatively reliable metric, i.e., the annual-mean latitude of tropical cyclone (TC) lifetime maximum intensity, to evaluate the observed trend of poleward migration of TC. The documented trend in the existing records of the metric suggests that anthropogenic factors might make considerable contributions to the poleward migration of TC. However, here we show that there is no significant TC migration trend in the western North Pacific (WNP). Instead, large interdecadal variation is found in the WNP TC track over the past 35 years. Rather than the anthropogenic factors, it is the natural variability, especially the Interdecadal Pacific Oscillation (IPO), that plays a key role in modulating the migration of WNP TC track. The IPO-related TC migration is assumed to cause systematic changes (i.e., increases and decreases) in regional hazard exposure and risk. The impact of IPO on the WNP TC migration is attributed to its influences on the large-scale circulation, TC genesis potential index, and the potential intensity in the TC prevailing region of the WNP.
Large Versus Small Gastric Pouch for Roux-en-Y Gastric Bypass in Individuals With Type 2 Diabetes and a Body Mass Index < 35 kg/m2: Six-Year Outcomes
Authors: Gao Xiang , Dai Song , Wang Guohui , Li Weizheng , Song Zhi , Su Zhihong , Zhu Shaihong , Zhu Liyong , Li Pengzhou 
Published: September 2022

BackgroundRoux-en-Y gastric bypass (RYGB) results in extraordinary weight loss and glycemic control outcomes for patients with obesity; however, the effect of gastric pouch size is still unclear, and the reported results are contradictory. Additionally, long-term data on type 2 diabetes (T2D) patients with low body mass index (BMI) are sparse. This study was to assess the effect of 6-year outcomes in Chinese patients with T2D and a BMI &lt; 35 kg/m2 who underwent RYGB with gastric pouches of different sizes.MethodsA retrospective cohort study was performed. There were 42 patients in the large gastric pouch group (L) and 53 patients in the small gastric pouch group (S). Baseline demographic history, pre- and postoperative BMI, waist circumference, and glucose- and lipid metabolism-related indicators were compared.ResultsAssessments were completed in 100%, 100%, 93.6%, and 89.4% of patients at baseline, 1 year, 3 years, and 6 years, respectively. At 6 years, the changes in BMI and fasting plasma glucose were greater in the S group (-4.25 ± 0.51 kg/m2 and -4.58 ± 0.73 mmol/l) than in the L group (-2.06 ± 0.48 kg/m2 and -2.64 ± 0.61 mmol/l). The independent predictors of complete remission of T2D were preoperative BMI and the size of the gastric pouch. A large gastric pouch was associated with a higher risk for marginal ulcers.ConclusionsA small gastric pouch results in better weight loss and glycemic control. High preoperative BMI and a small gastric pouch are associated with better T2D remission rates. A large gastric pouch leads to a higher incidence of marginal ulcers.
Research on the spatial effect of foundation pit under asymmetric loads
Authors: Xu Changjie , Lin Zhaorui , Jiang Yalong , Shi Yufeng , Fan Xiaozhen , Xiong Zheng , Liu Yangfeng 
Published: September 2022

Abstract: This research describes the evolution of the spatial effects of foundation pits considering internal support and external loads. Based on the existing concept of “plane strain ratio”, the term “plane strain ratio considering maximum surface settlement” is proposed to characterize the spatial effects of an asymmetric foundation pit. A series of finite element model calculations were carried out using the Nanchang Aixi Lake foundation pit, including 1) the calculation of simulated actual conditions, 2) the calculation of simulated full symmetric load, and 3) the calculation of simulated asymmetric load. The results indicate that for the symmetric condition at 20 kPa and below, the spatial effect range increases as the load increases. For the symmetric condition above 20 kPa, the load has a negligible impact on the spatial effect range. On the side with a larger load under asymmetric loading conditions, the spatial effect of the working condition below 30 kPa is smaller than the corresponding symmetric load. On the side with a smaller load, the spatial effect of the working condition above 80 kPa increases compared with that of the corresponding symmetrical load. Given and verified are the modified fitting equations that take into account the influence range of spatial effect on both sides of the foundation pit under symmetrical and asymmetrical loads.
Gasdermin D: A potential mediator and prognostic marker of bladder cancer
Authors: El-Gamal Randa , Abdelrahim Mona , El-Sherbiny Mohamed , Enan Eman T. , El-Nablaway Mohammad 
Published: September 2022

Background: Bladder cancer is considered one of the commonest widespread cancers, its presentation ranges from non-muscle invasive form to being muscle-invasive. The gasdermin family of proteins consists of six proteins. Members of gasdermin family are involved in pyroptosis; which is considered as type of inflammatory apoptosis via participation of gasdermin D and inflammatory caspases.Purpose: The goal of this research was to look into the potential involvement of gasdermin D in pathogenesis of bladder cancer, In addition, to investigate its potential role as a prognostic marker of bladder cancer.Methods: Gasdermin D gene and protein expression was examined in fresh frozen 80 bladder cancer specimens (30 NMIBC, and 50 MIBC) and the matching 80 control tissue samples utilizing real-time polymerase chain reaction and western blotting. Furthermore, the immunoreactivity of gasdermin D protein was also detected by immunohistochemistry.Results: Gasdermin D gene and protein expression showed a highly significant difference between the control and the two bladder cancer groups (p &lt; 0.001), as demonstrated by real-time PCR, western blotting and immunohistochemistry. Cox proportional hazards regression models showed that lower gasdermin D gene expression in cancer patients (≤1.58-fold), and younger age (≤53 years) were linked with a higher risk of local tumor recurrence. Moreover, higher gasdermin D gene expression (&gt;2.18-fold), and lymph nodes’ involvement were associated with an increased mortality.Conclusion: Gasdermin D is involved in the pathogenesis of bladder cancer and muscle invasion, in addition, tissue gasdermin D expression may be used as useful tool to predict local tumor recurrence.
The stress hyperglycemia ratio is associated with the development of cerebral edema and poor functional outcome in patients with acute cerebral infarction
Authors: Deng Yilun , Wu Simiao , Liu Junfeng , Liu Meng , Wang Lu , Wan JinCheng , Zhang Shihong , Liu Ming 
Published: September 2022

Background and purposeAbsolute hyperglycemia at admission has been shown to be associated with the development of cerebral edema (CED) after acute cerebral infarction. Stress hyperglycemia is a more objective reflection of hyperglycemic state than absolute hyperglycemia. However, studies on the associations between stress hyperglycemia and CED are limited. We aimed to explore the associations of stress hyperglycemia, measured by stress hyperglycemia ratio (SHR), with the development of CED and poor functional outcome of acute cerebral infarction.MethodsPatients with acute middle artery cerebral infarction admitted to the Department of Neurology, West China Hospital of Sichuan University, within 24 h of symptom onset from January 2017 to March 2021 were included. Stress hyperglycemia was assessed by the SHR: admission fasting plasma glucose (FPG)/hemoglobin A1c (HbA1c). The primary outcome was the degree of CED evaluated on brain image. The secondary outcomes were moderate-to-severe CED, poor functional outcome (modified Rankin Scale score &gt; 2), and death at 90 days. The associations between the SHR and outcomes were assessed with multivariate logistic regression analyses. We further compared the predictive value of the SHR, admission random plasma glucose (RPG), and admission FPG for outcomes in the training dataset and validation dataset.Results638 patients were enrolled. Each 0.1-point increase in the SHR was independently associated with a 1.31-fold increased risk of a higher degree of CED [odds ratio (OR): 1.31 (95% confidence interval (CI): 1.20–1.42), P &lt; 0.001]. The SHR was independently associated with moderate-to-severe CED [per 0.1-point increase: OR: 1.39 (95% CI: 1.24–1.57), P &lt; 0.001], poor functional outcome [per 0.1-point increase: OR: 1.25 (95% CI: 1.12–1.40), P &lt; 0.001], and death [per 0.1-point increase: OR: 1.13 (95% CI: 1.03–1.25), P &lt; 0.05]. The predictive value of the SHR (as a continuous variable), exhibited by the area under the curve in receiver operating characteristic analysis, was higher than that of the RPG and FPG for moderate-to-severe CED and poor functional outcome (P &lt; 0.05).ConclusionThe SHR is independently associated with the severity of CED, poor functional outcome, and death after acute cerebral infarction, and the SHR (as a continuous variable) has a better predictive value for moderate-to-severe CED and poor functional outcome than the RPG and FPG.
Aberrant pattern of regional cerebral blood flow in mild cognitive impairment: A meta-analysis of arterial spin labeling magnetic resonance imaging
Authors: Tang Tong , Huang Li , Zhang Yusi , Li Zuanfang , Liang Shengxiang 
Published: September 2022

In mild cognitive impairment (MCI), cognitive decline is associated with abnormal changes of cerebral blood flow (CBF). Arterial spin labeling magnetic resonance imaging (ASL-MRI) is an effective method for assessing regional cerebral blood flow (rCBF). However, the CBF estimated via ASL-MRI in MCI often differs between studies, and the consistency of CBF changes in MCI is unclear. In this study, 13 ASL-MRI studies with 495 MCI patients and 441 health controls were screened out from PubMed, Embase, Cochrane, Web of Science, Wanfang, and CNKI. An activation likelihood estimation (ALE) meta-analysis was performed to explore the brain regions with abnormal CBF in MCI. It showed that the decreased CBF in MCI was identified in the precuneus, inferior parietal lobule (IPL), superior occipital gyrus (SOG), middle temporal gyrus (MTG), and middle occipital gyrus (MOG), while the increased CBF in MCI was identified in the lentiform nucleus (LN) compared with healthy controls. The study characterized the abnormal pattern of regional CBF in MCI, which would promote our knowledge of MCI and might be used as a biomarker in clinic.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=259633.
High-resolution magnetic resonance imaging for predicting successful recanalization in patients with chronic internal carotid artery occlusion
Authors: Zhang Xuan , Zhou Chun , Cao Yue-zhou , Su Chun-qiu , Shi Hai-bin , Lu Shan-shan , Liu Sheng 
Published: September 2022

ObjectiveThe main aim of the study was to investigate the predictive factors of high-resolution magnetic resonance imaging (HR-MRI) for successful recanalization in patients with chronic internal carotid artery occlusion (CICAO).MethodsWe included 41 consecutive patients who had CICAO and underwent recanalization attempts. The demographics, clinical data, and HR-MRI features in relation to the technique success were collected and analyzed using univariate and multivariate analyses. A score-based prediction model was constructed using a regression coefficient-based scoring method.ResultsTechnical success was achieved in 26 (63.4%) patients, with a complication rate of 12.2% (5/41). Based on multivariate analysis, occlusions involving ophthalmic artery segment (C6) or above (OR: 0.036; 95% confidence interval [CI]: 0.004–0.336) and nontapered stump (OR: 0.064; 95% CI: 0.007–0.591) were identified as independent negative predictors of successful recanalization in patients with CICAO. Point scores were assigned according to the model coefficients, and the patients who scored 0, 1, or 2 points had success rates of 93.33% (14/15), 66.67% (12/18), or 0% (0/8), respectively.ConclusionHR-MRI characteristics may be valuable in identifying candidates for endovascular recanalization in patients with CICAO. Occlusions involving the C6 segment or higher, as well as nontapered stumps, were independent negative predictors of technical success.
Altered functional connectivity in first-episode and recurrent depression: A resting-state functional magnetic resonance imaging study
Authors: Sun Jifei , Du Zhongming , Ma Yue , Chen Limei , Wang Zhi , Guo Chunlei , Luo Yi , Gao Deqiang , Hong Yang , Zhang Lei , Han Ming , Cao Jiudong , Hou Xiaobing , Xiao Xue , Tian Jing , Yu Xue , Fang Jiliang , Zhao Yanping 
Published: September 2022

BackgroundFunctional magnetic resonance imaging (fMRI) studies examining differences in the activity of brain networks between the first depressive episode (FDE) and recurrent depressive episode (RDE) are limited. The current study observed and compared the altered functional connectivity (FC) characteristics in the default mode network (DMN), cognitive control network (CCN), and affective network (AN) between the RDE and FDE. In addition, we further investigated the correlation between abnormal FC and clinical symptoms.MethodsWe recruited 32 patients with the RDE, 31 patients with the FDE, and 30 healthy controls (HCs). All subjects underwent resting-state fMRI. The seed-based FC method was used to analyze the abnormal brain networks in the DMN, CCN, and AN among the three groups and further explore the correlation between abnormal FC and clinical symptoms.ResultsOne-way analysis of variance showed significant differences the FC in the DMN, CCN, and AN among the three groups in the frontal, parietal, temporal, and precuneus lobes and cerebellum. Compared with the RDE group, the FDE group generally showed reduced FC in the DMN, CCN, and AN. Compared with the HC group, the FDE group showed reduced FC in the DMN, CCN, and AN, while the RDE group showed reduced FC only in the DMN and AN. Moreover, the FC in the left posterior cingulate cortices and the right inferior temporal gyrus in the RDE group were positively correlated with the 17-item Hamilton Rating Scale for Depression (HAMD-17), and the FC in the left dorsolateral prefrontal cortices and the right precuneus in the FDE group were negatively correlated with the HAMD-17.ConclusionsThe RDE and FDE groups showed multiple abnormal brain networks. However, the alterations of abnormal FC were more extensive and intensive in the FDE group.
Nomogram for predicting traumatic subdural effusion after mild traumatic brain injury
Authors: Wei Lichao , Chang Bowen , Geng Zhi , Chen Ming , Cao Yongsheng , Yao Liang , Ma Chao 
Published: September 2022

ObjectiveTraumatic subdural effusion (TSE) is a common complication of traumatic brain injury (TBI). This study aimed to determine the risk factors associated with subdural effusion and to propose a nomogram to predict the risk of TSE in patients with mild TBI.MethodsWe retrospectively analyzed 120 patients with mild TBI between January 2015 and December 2020 at the Third People's Hospital of Hefei. The risk factors of TSE were selected using univariate and multivariable logistic regression analysis. A nomogram was developed to predict the incidence of TSE. Receiver operating characteristics and calibration plots were used to evaluate the discrimination and fitting performance.ResultsOf the 120 patients, 32 developed subdural effusion after mild TBI. Univariate analysis showed that gender, age, history of hypertension, traumatic subarachnoid hemorrhage, subdural hematoma, basilar skull fracture, and cerebral contusion were varied significantly between groups (p &lt; 0.05). Logistic multivariate regression analysis showed that the gender, age, history of hypertension, and basilar skull fracture were independent risk factors for TSE. Based on these results, a nomogram model was developed. The C-index of the nomogram was 0.78 (95% CI: 0.70–0.87). The nomogram had an area under the receiver operating characteristic curve of 0.78 (95% CI: 0.70–0.87). The calibration plot demonstrated the goodness of fit between the nomogram predictions and actual observations.ConclusionGender, age, history of hypertension, and basilar skull fracture can be used in a nomogram to predict subdural effusion after mild TBI.
Combining visual rating scales to identify prodromal Alzheimer's disease and Alzheimer's disease dementia in a population from a low and middle-income country
Authors: Custodio Nilton , Malaga Marco , Chambergo-Michilot Diego , Montesinos Rosa , Moron Elizabeth , Vences Miguel A. , Huilca José Carlos , Lira David , Failoc-Rojas Virgilio E. , Diaz Monica M. 
Published: September 2022

BackgroundMany low- and middle-income countries, including Latin America, lack access to biomarkers for the diagnosis of prodromal Alzheimer's Disease (AD; mild cognitive impairment due to AD) and AD dementia. MRI visual rating scales may serve as an ancillary diagnostic tool for identifying prodromal AD or AD in Latin America. We investigated the ability of brain MRI visual rating scales to distinguish between cognitively healthy controls, prodromal AD and AD.MethodsA cross-sectional study was conducted from a multidisciplinary neurology clinic in Lima, Peru using neuropsychological assessments, brain MRI and cerebrospinal fluid amyloid and tau levels. Medial temporal lobe atrophy (MTA), posterior atrophy (PA), white matter hyperintensity (WMH), and MTA+PA composite MRI scores were compared. Sensitivity, specificity, and area under the curve (AUC) were determined.ResultsFifty-three patients with prodromal AD, 69 with AD, and 63 cognitively healthy elderly individuals were enrolled. The median age was 75 (8) and 42.7% were men. Neither sex, mean age, nor years of education were significantly different between groups. The MTA was higher in patients with AD (p &lt; 0.0001) compared with prodromal AD and controls, and MTA scores adjusted by age range (p &lt; 0.0001) and PA scores (p &lt; 0.0001) were each significantly associated with AD diagnosis (p &lt; 0.0001) but not the WMH score (p=0.426). The MTA had better performance among ages &lt;75 years (AUC 0.90 [0.85–0.95]), while adjusted MTA+PA scores performed better among ages&gt;75 years (AUC 0.85 [0.79–0.92]). For AD diagnosis, MTA+PA had the best performance (AUC 1.00) for all age groups.ConclusionsCombining MTA and PA scores demonstrates greater discriminative ability to differentiate controls from prodromal AD and AD, highlighting the diagnostic value of visual rating scales in daily clinical practice, particularly in Latin America where access to advanced neuroimaging and CSF biomarkers is limited in the clinical setting.
The central-peripheral coupling effect of ocular acupuncture kinesitherapy in post-stroke dyskinesia: A functional neuroimaging and neurotic electrophysiology study protocol
Authors: Zhang Di , Wang Yongshen , Li Hongpeng , Ma Jiang , Sun Jianfeng , Wu Zhipeng , Zhang Guilong , Jin Song 
Published: September 2022

BackgroundDyskinesia is a common manifestation after stroke. Motor functional rehabilitation after stroke is of great significance to the maintenance of national health. Ocular Acupuncture Kinesitherapy (OAKT) can repair nerve injuries, improve motor function, reduce rehabilitation time, and promote dyskinesia recovery after stroke. The mechanism, however, remains a mystery, necessitating urgent research. The M1-thalamus-spinal cord neural signaling pathway is linked to limb motor function. Bold-fMRI can represent the cerebral functional state, and TMS-MEP is of certain practical utility for assessing motor neural function and prognosis. Combining fMRI scanning with TMS-MEP detection is predicted to advance brain-spinal cord regulation and muscle response linkage control mechanism research, as well as completely investigate the central-peripheral coupling effect of Ocular Acupuncture Kinesitherapy on dyskinesia after stroke (PSD).MethodsThis is a prospective functional neuroimaging and neurotic electrophysiological study with a case-control design between the PSD with the HC groups and a randomized controlled design within the 3 PSD groups (OAKT group, ocular acupuncture group, and kinesitherapy group). Using fMRI scans and TMS-MEP approach, we will assess the central-peripheral neural function alterations in PSD as well as the coupling effects of OAKT on PSD. We plan to enroll 90 participants at the Hospital of Chengdu University of Traditional Chinese Medicine from Aug 31, 2022, to Dec 31, 2023, including 45 PSD and 45 HC subjects. After enrollment and on the last day after 4-weeks of waiting (HC subjects) or intervention (PSD subjects), all eligible subjects will be evaluated using fMRI scanning, TMS-MEP detection, and the MMT and Fugl-Mayer scales assessment. The MMT and Fugl-Meyer scores will be recorded, and a Pearson correlation analysis will be performed to assess the correlation between clinical and imaging outcomes.DiscussionFindings of this study will help to explain the central-peripheral coupling effect of OAKT on PSD and to further provide the neural processing of acupuncture kinesitherapy covering the entire pathway from peripheral to central nervous system.Clinical trial registrationThis study is registered with an identifier (ChiCTR2200060483) at the Chinese Clinical Trial Registry in June 2022. http://www.chictr.org.cn/index.aspx.