bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative Three-Dimensional Measurement-Based Periareolar Augmentation Mastopexy: Indication and Breast Crown Approach
Authors: Ma Xiaomu , Xu Boyang , Ouyang Yiye , Du Xingyi , Liu Chunjun 
Published: June 2022

Summary:
At present, there is no uniform and quantitative indication standard for periareolar augmentation mastopexy. The authors proposed an indication algorithm and a matched approach to delineate the outer circle, to optimize the result of this operation. Five parameters, including both implant and breast characteristics, were incorporated to form an indication algorithm based on three-dimensional measurement. The indication follows the principle that the circumference of the outer circle should be no more than two times the inner circle. To delineate the outer circle, a “crown” was made on the breast. The above approaches were used on patients who came for periareolar augmentation mastopexy from October of 2015 to January of 2019. Data analyzed included BREAST-Q score, areola diameter, the distance of the sternal notch to the nipple preoperatively and 1 year postoperatively, the distance of nipple elevation 1 year postoperatively, and complication and revision rates. A total of 28 breasts (14 patients) were included in this study. BREAST-Q scores 1-year postoperatively showed significant increases in Satisfaction with Breasts, Psychosocial Well-Being, and Sexual Well-Being (p = 0.000). The mean areolar diameter preoperatively and postoperatively was 6.7 ± 1.2 cm and 4.6 ± 0.4 cm, respectively (p = 0.000), and the mean sternal notch–to-nipple distance preoperatively and postoperatively was 22.2 ± 1.9 cm and 18.6 ± 1.0 cm, respectively (p = 0.000), with an average nipple elevation of 3.2 ± 1.1 cm. The overall complication rate was 7.1 percent (n = 2); both cases were areolar spreading. The overall revision rate was 0 percent. This preliminary study demonstrated the safety and efficacy of the indication and breast crown approach in reducing complication and revision rates.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.
Profibrotic Signaling Pathways and Surface Markers Are Up-Regulated in Fibroblasts of Human Striae Distensae and in a Mouse Model System
Authors: Borrelli Mimi R. , Griffin Michelle , Chen Kellen , Deleon Diaz Nestor M. , Adem Sandeep , Mascharak Shamik , Shen Abra H. , Ngaage Ledibabari Mildred , Lewis Nicolette , Longaker Michael T. , Gurtner Geoffrey , Wan Derrick C. , Lorenz H. Peter 
Published: June 2022

Background:
Striae distensae are common disfiguring cutaneous lesions but lack effective treatments because of an incomplete understanding of their pathophysiology. Dermal fibroblasts likely play an important role. The authors investigate the cellular-molecular features distinguishing fibroblasts from human striae distensae and normal skin. The authors also develop a mouse model of striae distensae.

Methods:
Human striae distensae and normal skin samples were compared for tensile strength and histologic structure. Fibroblasts from striae distensae and normal skin were isolated by fluorescence-activated cell sorting for gene expression analysis. Immunofluorescence staining and fluorescence-activated cell sorting were used to confirm gene expression data at the protein level. A mouse model of striae distensae formation was created by administering corticosteroids and mechanically loading the dorsal skin.

Results:
Human striae distensae exhibited reduced tensile strength, more disordered collagen fibers, and epidermal atrophy compared to human normal skin. There were 296 up-regulated genes in striae distensae fibroblasts, including the profibrotic lineage and surface marker CD26. Up-regulated genes were involved in profibrotic and mechanoresponsive signaling pathways (TGFβ and FAK-PI3-AKT-signaling). In contrast, 571 genes were down-regulated, including CD74 and genes of the AMPK pathway. Increased CD26 and decreased CD74 expression was confirmed by fluorescence-activated cell sorting and immunofluorescence. Similar cutaneous histologic and gene expression changes were induced in hypercortisolemic mice by mechanically loading the dorsal skin.

Conclusions:
Fibroblasts from human striae distensae exhibit increased profibrotic and decreased antifibrotic signaling. CD26 and CD74 are promising surface markers that may be targeted therapeutically. The authors’ mouse model of striae distensae can be used as a platform to test the efficacy of potential therapeutic agents.

Clinical Relevance Statement:
Striae distensae are common disfiguring cutaneous lesions whose etiology remains elusive, which has hindered development of effective treatment strategies. Dermal fibroblasts likely play an important role. The authors sought to elucidate the key cellular-molecular pathways distinguishing fibroblasts in striae distensae from those in normal skin.
Using the Septal Shift Technique to Correct Crooked Nose Deformity
Authors: Karaca Harun 
Published: June 2022

Background:
Crooked nose deformity is defined as any degree of deviation of the anatomical structures involving the nasal bone, the upper and lower lateral cartilages, and the septum from the midsagittal plane of the face, in any direction.

Methods:
This study introduces a new technique to correct crooked nose deformity. Twenty-six with I-shaped, C- and reverse C-shaped, and S-shaped crooked nose deformity underwent open approach rhinoplasty. After performing in-out fracture osteotomy, L-strut septoplasty was preferred. Initially, the L-strut was sutured through the hole that opened to the maxillary spine and then passed to the dorsal section. In the dorsal part of the L-strut, a spreader graft with the appropriate thickness and length was sutured opposite to the deviated side, only at the keystone area. The L-strut was then incised vertically to form a cranial and caudal segment. The caudal portion was sutured by shifting to the other side of the spreader, beginning at the caudal end of the cranial portion. The upper lateral cartilages were sutured to the newly formed L-strut. Finally, tip-plasty was performed, and the procedure was terminated.

Results:
The septal shift technique is an effective method for treating crooked nose deformity.

Conclusion:
The septal shift technique is a new technique without complications used in the author’s routine practice as an effective method for treating crooked nose deformity.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.
PrEP Access Affected by COVID-19 Is Associated With Increased Odds of HIV Seroconversion
Authors: Morgan Ethan , Caba Antonia E. , Eaton Lisa A. , Watson Ryan J. 
Published: June 2022

Abstract:
Black and Hispanic/Latino sexual minority men and gender diverse (SMMGD) individuals report lower uptake and adherence to pre-exposure prophylaxis (PrEP) compared with White SMMGD. For some, the COVID-19 pandemic has resulted in reduced access to PrEP prescriptions and related changes to PrEP use, yet little is known how pandemic-related changes to PrEP access and sexual activity might influence sexually transmitted infection (STI) status and HIV seroconversion among SMMGD of color. We used data from 4 waves of a national study of Black and Hispanic/Latino SMMGD's HIV, PrEP, and health experiences to assess whether self-reported changes to sexual activity were associated with STI status, and whether self-reported changes to PrEP access were associated with HIV seroconversion. Those who reported greater impact to their sexual activity during the pandemic [adjusted odds ratio (aOR) = 1.24; 95% confidence interval (CI): 1.10 to 1.40] and a greater number of sexual partners (aOR = 1.29; 95% CI: 1.21 to 1.38) were more likely to report a positive STI test. In addition, we found that compared with those who did not report pandemic-related changes to PrEP access, those who did report changes to PrEP access had significantly higher odds of HIV seroconversion during the study period (aOR = 2.80; 95% CI: 1.02 to 7.68). These findings have implications for HIV and STI prevention and highlight the importance of novel interventions to improve PrEP access among Black and Hispanic/Latino SMMGD. Importantly, these findings also demonstrate the need to stay focused on key populations at risk of HIV infection during emerging public health crises to avoid an increase in rates of new diagnoses.
Biotypes of HIV-associated neurocognitive disorders based on viral and immune pathogenesis
Authors: Johnson Tory P. , Nath Avindra 
Published: June 2022

Purpose of review
HIV-associated neurocognitive disorders (HAND) continues to be prevalent in people living with HIV despite antiretroviral therapy. However, understanding disease mechanisms and identifying therapeutic avenues has been challenging. One of the challenges is that HAND is a heterogeneous disease and that patients identified with similar impairments phenotypically may have very different underlying disease processes. As the NeuroAIDS field is re-evaluating the approaches used to identify patients with HIV-associated neurological impairments, we propose the subtyping of patients into biotypes based on viral and immune pathogenesis.

Recent findings
Here we review the evidence supporting subtyping patients with HIV-associated neurological complications into four biotypes: macrophage-mediated HIV encephalitis, CNS viral escape, T-cell-mediated HIV encephalitis, and HIV protein-associated encephalopathy.

Summary
Subtyping patients into subgroups based on biotypes has emerged as a useful approach for studying heterogeneous diseases. Understanding biotypes of HIV-associated neurocognitive impairments may therefore enable better understanding of disease mechanisms, allow for the development of prognostic and diagnostic markers, and could ultimately guide therapeutic decisions.
Battlefield pain summit 2022: Expert consensus statements
Authors: Stark Thomas R. , Davidson Nathan L. , Cannon Jeremy W. , Polk Travis M. , Shackelford Stacy A. , Stallings Jonathan D. , Cap Andrew P. ,   the Battlefield Pain Research Steering Committee and Panel Discussion Members∗
Published: June 2022

BACKGROUND
Battlefield pain occurs in combat casualties who experience multiple severe injuries. The nature of battlefield scenarios requires a distinct approach to battlefield pain research. A battlefield pain summit was thus convened to identify shortcomings in the current understanding of battlefield pain management, review the current state of battlefield pain research, and shape the direction of future research.

METHODS
On January 10 to 11, 2022, a hybrid in-person and virtual meeting hosted by the US Army Institute of Surgical Research defined research priorities for the Combat Casualty Care Research Program's Battlefield Pain research portfolio. Summit participants identified the following key focus areas under the umbrella of battlefield pain research: battlefield injury patterns; use of ketamine and nonopioid analgesics; analgesic delivery systems; the impact of analgesia on performance, cognition, and survival; training methods; battlefield regional anesthesia; and research models. Preliminary statements presented during the summit were refined and rank ordered through a Delphi process.

RESULTS
Consensus was achieved on 7 statements addressing ideal analgesic properties, delivery systems, operational performance concerns, and pain training. Ketamine was identified as safe and effective for battlefield use, and further research into nonopioid analgesics represented a high priority.

CONCLUSION
The 7 consensus statements that emerged from this battlefield pain summit serve as a template to define the near-term research priorities for military-specific battlefield pain research.
Aurantiacibacter sediminis sp. nov., a marine bacterium isolated from a tidal flat
Authors: Kim Chul-Hwan , Yoo Yeonjae , Kim Dongjun , Khim Jong Seong , Pathiraja Duleepa , Kim Bogun , Choi In-Geol , Kim Jae-Jin 
Published: June 2022

A yellow-coloured bacterium, designated as strain JGD-13T, was isolated from a tidal flat in the Republic of Korea. Cells were Gram-stain-negative, aerobic, non-flagellated and rod-shaped. Growth was observed at 4–42 °C (optimum, 30 °C), at pH 6.0–12.0 (pH 7.0–8.0) and at 1–7 % (w/v) NaCl concentration (3 %). The 16S rRNA gene sequence analysis indicated that strain JGD-13T was closely related to

Aurantiacibacter gangjinensis

K7-2T with a sequence similarity of 98.2 %, followed by

Aurantiacibacter aquimixticola

JSSK-14T (98.1 %),

Aurantiacibacter atlanticus

s21-N3T (97.6 %),

Aurantiacibacter zhengii

V18T (97.6 %) and

Aurantiacibacter luteus

KA37T (97.5 %). The average nucleotide identity and digital DNA–DNA hybridization values with related strains were 70.3–76.2 % and 18.5–20.3 %. The genomic DNA G+C content was 60.2 mol%. Phylogenetic analysis using the maximum-likelihood method showed that strain JGD-13T formed a clade with

A. aquimixticola

JSSK-14T and

A. gangjinensis

K7-2T. The major fatty acids were summed feature 8 (39.7 %) and C17 : 1
ω6c (14.4 %). The predominant respiratory quinone was ubiquinone-10. The polar lipids were phosphatidylethanolamine, phosphatidylglycerol, phosphatidylcholine, one sphingoglycolipid and three unidentified lipids. On the basis of phylogenetic, phenotypic and chemotaxonomic characteristics, strain JGD-13T represents a novel species within the genus

Aurantiacibacter

, for which the name Aurantiacibacter sediminis JGD-13Tsp. nov. is proposed. The type strain is JGD-13T (=KCTC 72892T=KACC 21676T=JCM 33995T).
Analysis of microglial BDNF function and expression in the motor cortex
Authors: Honey Diana , Klann Eric , Weinhard Laetitia 
Published: June 2022

AbstractBrain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates several aspects of brain function. Although numerous studies have demonstrated the expression and function of BDNF in neurons, its expression in microglia remains controversial. Using a combination of genetic tools and fluorescence imaging, we analyzed BDNF expression pattern and interrogated the effect of microglial BDNF deletion on neuronal activity, early-stage spine formation, and microglia-neuron interactions in the motor cortex. Our results suggest that microglia do not express BDNF in sufficient amounts to modulate neuronal function.
scDeepC3: scRNA-seq Deep Clustering by A Skip AutoEncoder Network with Clustering Consistency
Authors: Wu Gang , Jiang Junjun , Liu Xianming 
Published: June 2022

ABSTRACTSingle-cell RNA sequencing (scRNA-seq) reveals the heterogeneity and diversity among individual cells and allows researchers conduct cell-wise analysis. Clustering analysis is a fundamental step in analyzing scRNA-seq data which is needed in many downstream tasks. Recently, some deep clustering based methods exhibit very good performance by combining the AutoEncoder reconstruction-based pre-training and the fine-tune clustering. Their common idea is to cluster the samples by the learned features from the bottleneck layer of the pre-trained model. However, these reconstruction-based pre-training cannot guarantee that the learned features are beneficial to the clustering. To alleviate these issues, we propose an improved scRNA-seq Deep Clustering method by a skip AutoEncoder network with Clustering Consistency (i.e., named scDeepC3) from two aspects, an efficient network structure and a stable loss function. In particular, we introduce an adaptive shortcut connection layer to directly add the shallow-layer (encoder) features to deep-layer (decoder). This will increase the flow of forward information and back-forward gradients, and make the network training more stable. Considering the complementarity between the features of different layers, which can be seen as different views of the original samples, we introduce a clustering consistency loss to make the clustering results of different views consistent. Experimental results demonstrate that our proposed scDeepC3 achieves better performance than state-of-the-arts and the detailed ablation studies are conducted to help us understand how these parts make sense.
The de-industrialisation discourse and the loss of modern industrial heritage in the Arab world: Jordan as a case study
Authors: Jarrar Nedhal , Jaradat Suha 
Published: June 2022

PurposeIndustrial heritage is considered an essential part of cultural heritage in the world. This heritage suffers from continued marginalisation in the Arab world, particularly in Jordan, where many industrial heritage sites have not been protected or studied well due to the lack of a clear definition of cultural heritage. Most of these sites, built in the 20th century, are gradually disappearing or scheduled for demolition. This paper explores the de-industrialisation discourse and the loss of modern industrial heritage in the Arab world, especially in Jordan.Design/methodology/approachThis research investigates the modern industrial heritage in Jordan as a case study in the Arab world. A comprehensive understanding of the industrial heritage has been obtained by adopting a case study approach and using a reconnaissance survey of potential industrial heritage sites in Jordan.FindingsSeven categories were used in the analysis of the de-industrialisation phenomenon of heritage sites: ownership, location, design and types; structure, significance, deterioration and physical condition and conservation attempts and alterations. Three main approaches to industrial heritage were identified: demolition, occasional maintenance and rare examples of conservation and adaptive reuse.Research limitations/implicationsThis study sheds light on the ownership issue of industrial structures in Jordan and invites policymakers, relevant authorities, private organisations and the public to consider the challenges and impact of de-industrialisation of such sites.Originality/valueThis research raises awareness of the de-industrialisation discourse, and highlights the value of industrial architecture dating back to the modernity period, which was short-lived in Jordan. It also calls for serious consideration of these sites to support sustainable development in the Arab World.
The economic domino effect on housing and construction sector – a case of India
Authors: B. Madhumitha , Onkar Preeti 
Published: June 2022

Purpose
This study aims to understand the domino effect on housing and construction sector along the economic dimensions in light of COVID-19 pandemic.

Design/methodology/approach
The view point in this paper is written based on the domino effect of various sectors in India. Starting from the macro-economic events through to the micro-economic events, the changes are discussed along the platform of COVID-19. Early literature to support the discussions and a wide range of periodicals to observe the current events are used in arriving at a hypothesis.

Findings
The impact in any sector does not happen because of a sole event rather it is consequence of changes and trends that took place in multiple sectors. This paper identifies such changes in the sectors of oil industry, cement manufacturing, housing and construction sector during COVID-19. The paper concludes on confirming the hypothesis with two opinions. One by accepting the principle of domino effect that construction domain had various impacts by other sectors at different levels during pandemic. Another on considering the level of impact, the sector has withstood the impacts in various manners and is growing in extensive directions proving the sector to be resilient.

Originality/value
The paper showcases the impacts of various sectors on construction domain with an insight of most recent trends supported by early literature. The linking of elements is the significance of the paper.
Harmonious entrepreneurship: evolution from wealth creation to sustainable development
Authors: Kirby David Anthony , El-Kaffass Iman , Healey-Benson Felicity 
Published: June 2022

Purpose
The purpose of this research is to examine the evolution of entrepreneurship, explain the reasons for why it is not contributing significantly to the global sustainability challenge and propose a new approach and business model to better enable it to do so.

Design/methodology/approach
The research adopts a grounded theory–style approach based on case study production and analysis using secondary data and, where appropriate, personal observation.

Findings
The paper concludes that entrepreneurship has failed to address the sustainability challenge because of its emphasis on “making as much money as possible” and its failure to appreciate that the planet is a system. It concludes that for any solution to be successful it must be based on systems thinking and should integrate or harmonise the traditional, separately applied approaches to entrepreneurship in order to produce a business model with a Triple Bottom Line, whereby Profit, Planet and People are in Harmony.

Research limitations/implications
While the proposed model is based on a real-life case, it needs to be tested in different politico-economic contexts and industry sectors. It has the potential, though, to impact very considerably the traditional thinking on entrepreneurship and its application.

Practical implications
The proposed new approach will have significant implications for entrepreneurship education and training, including the adoption of a stakeholder rather than shareholder approach to management.

Social implications
Sustainability is arguably the most urgent and critical problem facing contemporary society. The proposed model provides a potential solution to that problem, particularly at the local community level.

Originality/value
The research proposes a new approach to entrepreneurship that breaks with the Friedman (1970) mantra that the purpose of business is to “make as much money as possible”.
Do celebrity endorsements influence stock investment intentions?
Authors: Shiva Atul , Arora Nilesh , Rishi Bikramjit 
Published: June 2022

PurposeCelebrity endorsement is a preferred marketing communication strategy adopted by business firms. The present study suggests theoretical underpinnings for investigating the effect of celebrity endorsement on individual investors' intentions to invest in the shares of companies. The study integrates marketing communication and behavioural finance theories to understand investor behaviour in the stock market.Design/methodology/approachThe study used a questionnaire based on a conjoint analysis technique. The retail investors from India filled out the questionnaire. The authors developed an orthogonal design to generate retail investors' investment intentions and applied the full-profile conjoint method.FindingsThe results reveal that investors prefer to invest in technology-related firms when they employ entertainment celebrities to endorse their products. Investors prefer that entertainment celebrities' personalities match the single brand only they are endorsing. Further, investors choose to invest during corrective market trends in emerging economies, such as India.Originality/valueThe study offers practical implications for corporate entities and marketing professionals by analysing retail investors' investment intentions in financial markets.