bluuebunny/crossref_metadata_2025_split huggingface dataset:
The comparison between 2DE‐MS and bottom‐up LC‐MS demands high‐end techniques for both technologies
Authors: Zhan Xianquan , Jungblut Peter R. 
Published: March 2022

AbstractIn contrast to bottom‐up LC‐MS only 2DE‐MS can separate and detect a huge number of human protein species. Kwiatkowski et al. (in this issue) established parameters to estimate the amount of protein speciation for each human protein. Proteins identified in 2DE‐MS approaches showed more protein speciation than in bottom‐up LC‐MS. The authors state that protein speciation is likely to increase the chance of proteins to be determined in 2‐DE/MS, though admitting that low‐sensitivity 2DE‐MS methods were used in this study. In agreement with Kwiatkowski et al., we are convinced that the difference between 2DE‐MS and bottom‐up LC‐MS will disappear, if high‐resolution 2DE is combined with identification by a high‐sensitivity LC‐Orbitrap‐MS. Meta‐analysis of proteomic data is surely a promising tool, though the technological progress in 2DE and MS has to reach a plateau to enable useful comparisons.
Electrochemical interfaces in ionic liquids/deep eutectic solvents incorporated with water: A review
Authors: Liu Shuai , Tan Zhuo , Wu Jiedu , Mao Bingwei , Yan Jiawei 
Published: March 2022

AbstractIonic Liquids (ILs) and deep eutectic solvents (DESs) are promising candidate electrolytes in electrochemical fields due to their excellent properties. They can absorb water from the environment quickly, the existence of water in ILs/DESs benefits or harms their performance depending on the purpose of the applications. Therefore, studies on the effect of water on the properties of ILs/DESs have received much attention in recent years. This mini‐review provides an overview of the structure of the electrochemical interface in ILs/DESs incorporated with water by summarizing the information acquired from a variety of characterization technologies and simulations. Both our understanding of the interfacial structure and our perspective on further research in the field are presented.
The effects of intake temperature on reactivity controlled compression ignition combustion under high load
Authors: Zhang Yuxin , Xia Qi , Xu Yuanli , Liu Yichi , Wei Zengna , Sun Miaozhong 
Published: March 2022

AbstractIn order to improve of high loaded diesel engine with high ethanol substitution rate, the effects of intake temperature on the combustion characteristics and generation characteristics of pollutants in cylinder from reactivity controlled compression ignition (RCCI) engine under high load was studied numerically. RCCI experimental data were obtained from a four cylinder turbocharged diesel engine fuel modified to run with diesel/ethanol dual fuel in the study. The simulation was performed via converge computational fluid dynamics (CFD) code, and numerical results were validated with the experimental data. The parameters such as cylinder pressure, cylinder temperature, heat release rate (HRR), CA10, CA50, indicated thermal efficiency, maximum pressure rise rate, NOx, soot, HC and CO emissions were investigated at 2000 rpm engine speed and high engine load (80% full load). The results show that decreasing intake temperature reduces the peaks of cylinder pressure and cylinder temperature, the HRR profile changes from double peak to single peak; the CA10 and the CA50 is retarded; maximum pressure rise rate and indicated thermal efficiency decrease. In addition, with the decreasing of intake temperature, the peaks of NOx, soot and CO generated in cylinder decreases, while the peaks of unburned HC generated in cylinder almost remain constant. Thus it can be seen that using optimal intake temperature is an effective way to improve ethanol substitution rate of diesel engine under high load.
Catastrophic overwash and rapid retreat of a gravel barrier spit during storm events (Sillon de Talbert, North Brittany, France)
Authors: Suanez Serge , Stéphan Pierre , Autret Ronan , Houron Julien , Floc'h France , David Laurence , Ammann Jérôme , Accensi Mickael , André Gaël , Le Guyader Damien , Cancouët Romain 
Published: March 2022

AbstractThe morphodynamic functioning of the Sillon de Talbert gravel barrier spit is analysed using a high‐frequency survey carried out between September 2012 and December 2019. It is based on beach profile measurements along two transects, modelling offshore wave data (WW3), tide gauge records, and shallow waves and water levels recorded in the intertidal zone. A barrier retreat of −23 to −30 m over the 7‐year survey (i.e. −3.3 to −4.3 m yr−1) is measured. This retreat is not related to long‐term sea level rise (macroscale of 102–103 yr), but to mesoscale (100–102 yr) morphogenic events combining storm wave and high spring tide. Over 87–90% of the barrier retreat is due to three significant events (1–2 February 2014, 9 February 2016, and 3 January 2018). The storm impact scale model of Orford and Carter is tested. The estimation of the wave runup for the calculation of extreme water levels [i.e. peak overflow elevation (Oe) component] is based on the calibration of an equation performed from in‐situ measurements of the swash elevation. The flow depth (Od,q) overtopping the crest of the barrier (Bh) is thresholded by taking into account the morphological response of the barrier in order to define regimes corresponding to overtopping, discrete overwash, and sluicing overwash. While the Orford and Carter model is generally successful in reproducing the morphodynamic evolution of Sillon de Talbert, the wave energy flux (F) must be considered as an additional parameter in order to improve the fit of the model, so far as it contributes in some cases to change the morphodynamic regime. Thus, the wave energy flux constitutes a key component in the quantification of the water flow across the barrier (Od,q) corresponding to the hydrodynamic forcing of the model, which becomes (Od,F).
Evaluation of the physicochemical parameters of edible oils sold in the three cities of Burkina Faso
Authors: Kaboré Kabakdé , Konaté Kiéssoun , Sama Hemayoro , Dakuyo Roger , Sanou Abdoudramane , Bazié David , Diao Mamounata , Dicko Mamoudou Hama 
Published: March 2022

AbstractThe edible oil needs of African countries are met by imported or locally produced ones. Therefore, consumers are generally confronted with a choice of edible oils of poorly controlled quality. However, quality control of edible oils for local consumption is of high necessity. This study aimed to assess the quality of edible oils sold and consumed in some cities in Burkina Faso. Oil samples collected in the cities of Dédougou, Koudougou, and Nouna were used for several analyses. Oil samples from palm, refined and unrefined cottonseed, and groundnut were collected. Standard methods were used to assess the physicochemical quality parameters of the oils, including the peroxide value, water and volatile matter content, acid value, traces of soap, and mineral oil contents. The parameters varied significantly depending on the oil type, but not by the locality of origin. The peroxide indices had varied from 3.24 to 39.99 mEq O2/kg oil. The acid indices varied from 0.22 mg KOH/g to 1.24 mg KOH/g. The water and volatile matter contents ranged from 0.04% to 0.88%. The test for traces of soap gave values ranging from 0 to 76 ppm. For the mineral oil test, four samples of cottonseed oil collected in Dedougou gave positive results. Compared to international reference standards, in particular the Codex Alimentarius standard, it may constitute a health risk for consumers. The poor storage, distribution, and marketing conditions of the oils could explain their poor quality. In order to provide consumers with quality oils, regular controls must be undertaken in the places where the oils are stored and/or marketed.
Patients with severe COVID‐19 have reduced circulating levels of angiotensin‐(1–7): A cohort study
Authors: Seyedmehdi Seyed Mohammad , Imanparast Fatemeh , Mohaghegh Pegah , Mahmoudian Saeed , Dehlaqi Mona Karimi , Mehvari Fatemeh , Abdullah Mihan Pour 
Published: March 2022

AbstractBackground and AimsAngiotensin‐converting enzyme 2 (ACE2) acts as a functional receptor for the entry of severe acute respiratory syndrome coronavirus 2 into host cells. Angiotensin (1–7) (Ang (1–7)) obtained from the function of ACE2 improves heart and lung function. We investigated the relationship between Ang (1–7) level and disease severity in patients with coronavirus disease 2019 (COVID‐19).MethodsThis cohort study was carried out at Masih Daneshvari Hospital in Tehran, Iran from September 2020 to October 2020. To do so, the Ang (1–7) levels of 331 hospitalized COVID‐19 patients with and without underlying disease were measured by ELISA kit. The need for oxygen, intubation, and mechanical ventilation were recorded for all the patients.ResultsResults showed a significant inverse relationship between the levels of Ang 1–7 and the severity of the disease (needed oxygen, intubation, and mechanical ventilation). According to the results, median (interquartile range) of Ang (1–7) levels was significantly lower in patients who needed oxygen versus those who needed no oxygen (44.50 (91) vs. 82.25 (68), p = 0.002), patients who needed intubation and mechanical ventilation versus those who did not (9.80 (62) vs. 68.70 (102), p < 0.000) and patients hospitalized in an intensive care unit (ICU) than people hospitalized in other wards. We also found that the older patients were more in need of ICU and mechanical ventilation than younger patients.ConclusionsHigher levels of Ang (1–7) have been associated with decreased disease severity. Besides this, we perceived that synthetic Ang 1–7 peptides may be useful to treat and reduce the complications of COVID‐19.
Finding the optimal mammography screening strategy: A cost‐effectiveness analysis of 920 modelled strategies
Authors: Kregting Lindy M. , Sankatsing Valérie D. V. , Heijnsdijk Eveline A. M. , de Koning Harry J. , van Ravesteyn Nicolien T. 
Published: March 2022

AbstractBreast cancer screening policies have been designed decades ago, but current screening strategies may not be optimal anymore. Next to that, screening capacity issues may restrict feasibility. This cost‐effectiveness study evaluates an extensive set of breast cancer screening strategies in the Netherlands. Using the Microsimulation Screening Analysis‐Breast (MISCAN‐Breast) model, the cost‐effectiveness of 920 breast cancer screening strategies with varying starting ages (40‐60), stopping ages (64‐84) and intervals (1‐4 years) were simulated. The number of quality adjusted life years (QALYs) gained and additional net costs (in €) per 1000 women were predicted (3.5% discounted) and incremental cost‐effectiveness ratios (ICERs) were calculated to compare screening scenarios. Sensitivity analyses were performed using different assumptions. In total, 26 strategies covering all four intervals were on the efficiency frontier. Using a willingness‐to‐pay threshold of €20 000/QALY gained, the biennial 40 to 76 screening strategy was optimal. However, this strategy resulted in more overdiagnoses and false positives, and required a high screening capacity. The current strategy in the Netherlands, biennial 50 to 74 years, was dominated. Triennial screening in the age range 44 to 71 (ICER 9364) or 44 to 74 (ICER 11144) resulted in slightly more QALYs gained and lower costs than the current Dutch strategy. Furthermore, these strategies were estimated to require a lower screening capacity. Findings were robust when varying attendance and effectiveness of treatment. In conclusion, switching from biennial to triennial screening while simultaneously lowering the starting age to 44 can increase benefits at lower costs and with a minor increase in harms compared to the current strategy.
A novel best‐worst‐method two‐stage data envelopment analysis model considering decision makers' preferences: An application in bank branches evaluation
Authors: Omrani Hashem , Alizadeh Arash , Emrouznejad Ali , Oveysi Zeynab 
Published: March 2022

AbstractData envelopment analysis (DEA) model has been applied for evaluating bank branches and recognizing efficient and inefficient branches can help bank managers to provide appropriate strategies to improve the inefficient branches' performance. Conventional DEA models are based on the ‘black box’ approach. However, the process of providing services in banks is made up of interactive and interdependent processes. Additionally, some managers tend to incorporate their preferences in evaluation process. In this paper, best worst method (BWM) is used for incorporating decision maker (DM) preferences in two‐stage DEA model. First, BWM model is applied to obtain the weights of inputs, intermediate measures and outputs based on DM's judgement. Second, generated weights are imposed on two‐stage DEA model as additional constraints and a novel bi‐objective BWM‐two stage DEA model is introduced. Finally, the proposed bi‐objective BWM‐two stage DEA model is solved using min‐max approach. To illustrate the capability of proposed model, 45 Agricultural Bank (Agribank) branches in West Azerbaijan province of Iran are evaluated. The branches' processes are considered as two stages ‘production’ and ‘profitability’ and efficiency of branches are calculated in each stage. According to the efficiencies of each sub‐stage, branches are divided to four groups and recommendations are made for each group.
Understanding the relationships between personal growth initiative, hope, and abstinence self‐efficacy
Authors: Niles Jennifer K. , Gutierrez Daniel , Dukes Allison T. , Mullen Patrick R. , Goode Corrinia D. 
Published: March 2022

AbstractLiterature suggests personal growth initiative (PGI) and hope play critical roles in problematic substance use. Authors describe the association between PGI and abstinence self‐efficacy (ASE) and the mediating factor of hope. Implications for addictions counselors and school counselors are provided.
The effect of person‐first language on attitudes toward people with addiction
Authors: Baker Emily A. , Hamilton Mark , Culpepper Danielle , McCune Grace , Silone Gabriella 
Published: March 2022

AbstractWe examined the impact of language on addiction stigma when using postmodified nouns versus premodified nouns. Use of postmodified nouns was associated with less authoritarian stigmatizing attitudes and higher benevolence than those who received the version with premodified nouns.
Randomized multi‐angle illumination for improved linear array photoacoustic computed tomography in brain
Authors: Manwar Rayyan , Lara Juliana Benavides , Prakash Ravi , Ranjbaran Seyed Mohsen , Avanaki Kamran 
Published: March 2022

AbstractOne of the key challenges in linear array transducer‐based photoacoustic computed tomography is to image structures embedded deep within the biological tissue with limited optical energy. Here, we utilized a manually controlled multi‐angle illumination technique to allow the incident photons to interact with the imaging targets for longer periods of time and diffuse further in all directions. We have developed and optimized a compact probe that enables manual changes to the angle of illumination while acquiring photoacoustic signals. The performance has been demonstrated and evaluated by imaging complex blood vessel mimicking phantoms in‐vitro and sheep brain samples ex‐vivo. For effective image reconstruction from the data acquired by multi‐angle illumination method, we have utilized a method based on the extraction of maximum intensity. In both cases, multi‐angle illumination has out‐performed the conventional fixed angle illumination technique to improve the overall image quality. Specifically, extraction of the imaging targets located at greater axial depths was possible using this multi‐angle illumination technique.
Disulfiram prevents collagen crosslinking and inhibits renal fibrosis by inhibiting lysyl oxidase enzymes
Authors: Saifi Mohd Aslam , Shaikh Arbaz Sujat , Kaki Venkata Rao , Godugu Chandraiah 
Published: March 2022

AbstractChronic kidney disease is one of the major health burdens affecting a considerable number of people worldwide. The aberrant regulation of lysyl oxidase (LOX) family of enzymes results in establishment of dense extracellular matrix (ECM). Since, LOX enzymes need copper (Cu) for their proper catalytic activity; the present study investigated the efficacy of a copper chelator, disulfiram (DSF) in renal fibrosis. Antifibrotic activity of DSF was investigated in kidney epithelial cells stimulated by transforming growth factor‐β1 (5 ng/ml) as well as in two animal models. The renal injury was induced in animals by unilateral ureteral obstruction and folic acid administration (250 mg/kg). The DSF (3 and 10 mg/kg, every 3rd day) and standard LOX inhibitor, β‐aminopropionitrile (BAPN, 100 mg/kg, daily) administration was started on day 0 and continued till the day of sacrifice. DSF was found to be a potent LOX/LOXL2 inhibitor to reduce crosslinking of collagen fibrils leading to reduction in the collagen deposition. In addition, the DSF was demonstrated to inhibit epithelial‐mesenchymal transition in the tubular cells and fibrotic kidneys. Our results suggested that DSF, being a clinically available drug could be translated to clinics for its potent antifibrotic activity due to its inhibitory effect on LOX proteins.
The role of Acidithiobacillus ferrooxidans in Fe(II) oxidation of pyrite in bioleaching processes
Authors: Kang Jin‐xing , Wang Ya‐yun 
Published: March 2022

AbstractBACKGROUNDMicrobial leaching is an emerging ore extraction technology, especially for low‐grade ores. In sulfide and oxide ore bioleaching systems, Acidithiobacillus ferrooxidans is becoming a widely applied microorganism for mineral processing. Many studies are currently focusing on the vital role of A. ferrooxidans in facilitating the efficiencies of sulfur and iron species transformation for sulfide ore bioleaching. Existing research usually investigates the composite action of A. ferrooxidans and Fe(III) for ore bioleaching, the effect of A. ferrooxidans alone being investigated to a lesser extent. An important effect is the role of A. ferrooxidans in the oxidative conversion of Fe(II) in pyrite bioleaching.RESULTSThe oxidative dissolution of pyrite in an imitated A. ferrooxidansbioleaching system was investigated in this work, particularly concerning the effects of bacteria on Fe(II) oxidation of the pyrite. Results of the dissolution performance test, cyclic voltammetry and polarization analysis indicated that the preceding oxidation of Fe(II) has control over the pyrite dissolution rate in the imitated bioleaching system. The semiconductor properties and carrier density of the passivation films of pyrite formed under a variety of conditions indicated that the oxidative leaching of ferrous disulfide is subject to the movement of the holes of the Fe2+species and the oxygen vacancy of H2O at the interface. Acidithiobacillus ferrooxidans promotes pyrite bioleaching by accelerating the preferential oxidation of Fe(II) caused by movement of the electron hole of Fe2+ to H2O at the solid–liquid interface.COCLUSIONThe oxidation process of pyrite in this study turns out to involve hole movement. © 2022 Society of Chemical Industry (SCI).
Effects of metformin on the uterus of d‐galactose‐induced aging mice: Histomorphometric, immunohistochemical localization (B‐cell lymphoma 2, Bcl2‐associated X protein, and active capase3), and oxidative stress study
Authors: Rempuia Vanlal , Anima Borgohain , Jeremy Malsawmhriatzuala , Gurusubramanian Guruswami , Pankaj Pranay P. , Kharwar Rajesh K. , Roy Vikas K. 
Published: March 2022

Abstractd‐galactose (DG)‐induced rodent aging model has widely been used for the study of age‐related dysfunctions of various organs, including gonads and uterus. Antidiabetic drug metformin has gained an attention as antiaging drug in model organism and human but its effect on uterus has not been studied in relation to induced aging. Therefore, we investigated the effect of metformin on uterus of DG‐induced aging mice model. Mice were randomly divided into three groups, that is, control (CN), DG‐induced aging model and aging model treated with metformin. Histomorphometric results showed significantly decreased number of uterine glands, endometrial thickness, and increased luminal epithelium height in aging model. Furthermore, metformin resumed the number of uterine glands, endometrial thickness, and luminal epithelium height up to CN group. Metformin has also significantly decreased the age‐associated oxidative stress (malondialdehyde and lipid hydroperoxide). Superoxide dismutase was significantly decreased in both treated groups compared to the CN group. However, catalase and glutathione peroxidase enzymes were significantly increased by metformin compared to the aging model. Immunostaining of active caspase3 and BAX were intense in the endometrium of aging model compare to CN‐ and metformin‐treated groups. Localization of B‐cell lymphoma 2 (Bcl2) showed intense immunostaining in the uterus of CN‐ and metformin‐treated groups, with mild immunostaining in aging model. Our observations suggested that metformin treatment might be helpful for management of age‐associated uterine dysfunctions. Moreover, it may be concluded that metformin might ameliorate uterine dysfunctions by reducing oxidative stress, suppressing apoptosis, and increasing the survival/antiapoptotic protein Bcl2.
Optimization of emission cost and economic analysis for microgrid by considering a metaheuristic algorithm‐assisted dispatch model
Authors: Somakumar Radhika , Kasinathan Padmanathan , Monicka Gayathri , Rajagopalan Arul , Ramachandaramurthy Vigna K. , Subramaniam Umashankar 
Published: March 2022

AbstractElectric vehicles (EVs) have witnessed a steady and continuous rise in the last few years. The increased prevalence of EVs results in high demand for electricity from the power grid and it can be effectively handled by combining EV charging infrastructure with renewable energy sources (RES). However, the intermittent characteristic of RES introduces an additional challenge to the power grid. This paper proposes a metaheuristic algorithm called self‐adaptive elephant herd optimization algorithm (SA‐EHO) to achieve the desired dispatch model of microgrid (MG) with EVs and RES. The proposed algorithm optimizes both economic and emission cost of MG which comprises diesel engine (DE), solar photovoltaic (PV), EVs, fuel cell (FC), wind turbine (WT), and loads. The output constraints associated with a distributed power supply such as power limits of distributed generators (DG) and charging of EVs followed by its discharging are subjected to optimization. Finally, the performance of the proposed model is compared and proved over other existing models. Especially, a minimal total cost of the proposed model is 16.79%, 21.58%, 20%, 26.67%, and 1.33% superior to traditional HSA, GA, EHO, MSA, and FS‐MSA models at 100th iteration. Furthermore, the reserved cost of the proposed scheme for the third scenario is 77.78%, 90.91%, 85.71%, 90.91%, and 90.91% superior to existing models such as HSA, GA, EHO, MSA, and FS‐MSA, respectively.