bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bristol UTraQ: A proposed system for scoring the technical quality of urodynamic traces
Authors: Gammie Andrew , Hashim Hashim , Abrams Paul 
Published: January 2022

AbstractAimTo develop and test a scoring system for the technical quality of a urodynamic traceMethodsRasch analysis was used to select the most discriminating questions relating to good urodynamic practices. The questions were taken from International Continence Society standard documents and tested on 60 traces of varying quality and from different sources.ResultsTwenty‐five questions were selected by this process. These were tested with 10 traces by seven scorers, and with 60 traces by a single scorer. A pass quality score of 75% resulted in good discrimination between good and poor traces. Further editing and clarification resulted in a final score sheet of 23 Yes/No questions.ConclusionA proposed scoring system, “Bristol UTraQ,” for the technical quality of urodynamic traces has been developed and tested. We suggest a score above 75% indicates acceptable trace technical quality. High technical quality is the essential first step in ensuring that urodynamic studies can answer the urodynamic questions for every patient. Plans for further validation are outlined.
Management strategies and outcome of ureterovaginal fistulae: A systematic review and meta‐analysis
Authors: Bahuguna Gunjan , Panwar Vikas K. , Mittal Ankur , Talwar Harkirat S. , Mandal Arup K. , Bhadoria Ajeet S. , Chapple Christopher 
Published: January 2022

AbstractBackgroundGenitourinary fistula is a distressful condition involving mental, social, marital, and financial repercussions.ObjectiveThe objective of this study is to systematically evaluate etiology, clinical presentation, diagnosis, the timing of repair, and perform a meta‐analysis evaluating the success rate of various treatment modalities with respect to time taken to seek treatment.Search strategyWe performed a critical review of PubMed/Medline, Embase, and the Cochrane Library in April 2020 according to the PRISMA statement. Seventeen studies were included in the final analysis and all were retrospective in design.Selection criteriaEach article was rated by the evidence‐based medicine levels of evidence scale and the Methodological Index for Nonrandomized Studies scale for assessment of bias among nonrandomized studies.Main resultsOf the 799 fistulae reported in 17 studies, endoscopic management was done in 35.6% (12 studies), whereas surgical management was preferred in 85.6% fistulae (15 studies). The pooled success of endoscopic stenting was 32% (95% confidence interval [CI]: 7–64) and 100% (95% CI: 98–100) in operated patients. Patients who underwent stenting within 2 weeks (20%), 2–6 weeks (21%), and >6 weeks (40%) had pooled success rates of 95% (95% CI: 87–100), 46% (95% CI: 0–100), and 20% (95% CI: 1–49), respectively. Patients who underwent surgical management <6 weeks (15.9%) and >6 weeks (22%) of diagnosis had pooled success rates of 100% (95% CI: 99–100) and 100% (95% CI: 99–100), respectively.ConclusionsStent placement as early as <6 weeks (preferably < 2 weeks) had better outcomes as compared to >6 weeks. Proceeding to surgery regardless of timing in cases of stent failure seems to be a feasible option.
Prediction of recurrence from metabolites and expression of TOP2A and EZH2 in prostate cancer patients treated with radiotherapy
Authors: Hansen Ailin Falkmo , Høiem Therese Stork , Selnæs Kirsten Margrete , Bofin Anna Mary , Størkersen Øystein , Bertilsson Helena , Wright Alan J. , Giskeødegård Guro Fanneløb , Bathen Tone Frost , Rye Morten Beck , Tessem May‐Britt 
Published: January 2022

BackgroundThe dual upregulation of TOP2A and EZH2 gene expression has been proposed as a biomarker for recurrence in prostate cancer patients to be treated with radical prostatectomy. A low tissue level of the metabolite citrate has additionally been connected to aggressive disease and recurrence in this patient group. However, for radiotherapy prostate cancer patients, few prognostic biomarkers have been suggested. The main aim of this study was to use an integrated tissue analysis to evaluate metabolites and expression of TOP2A and EZH2 as predictors for recurrence among radiotherapy patients.MethodsFrom 90 prostate cancer patients (56 received neoadjuvant hormonal treatment), 172 transrectal ultrasound‐guided (TRUS) biopsies were collected prior to radiotherapy. Metabolic profiles were acquired from fresh frozen TRUS biopsies using high resolution‐magic angle spinning MRS. Histopathology and immunohistochemistry staining for TOP2A and EZH2 were performed on TRUS biopsies containing cancer cells (n = 65) from 46 patients, where 24 of these patients (n = 31 samples) received hormonal treatment. Eleven radical prostatectomy cohorts of a total of 2059 patients were used for validation in a meta‐analysis.ResultsAmong radiotherapy patients with up to 11 years of follow‐up, a low level of citrate was found to predict recurrence,p = 0.001 (C‐index = 0.74). Citrate had a higher predictive ability compared with individual clinical variables, highlighting its strength as a potential biomarker for recurrence. The dual upregulation of TOP2A and EZH2 was suggested as a biomarker for recurrence, particularly for patients not receiving neoadjuvant hormonal treatment,p = 0.001 (C‐index = 0.84). While citrate was a statistically significant biomarker independent of hormonal treatment status, the current study indicated a potential of glutamine, glutamate and choline as biomarkers for recurrence among patients receiving neoadjuvant hormonal treatment, and glucose among patients not receiving neoadjuvant hormonal treatment.ConclusionUsing an integrated approach, our study shows the potential of citrate and the dual upregulation of TOP2A and EZH2 as biomarkers for recurrence among radiotherapy patients.
Impact of transition from face‐to‐face to telehealth on behavioral obesity treatment during the COVID‐19 pandemic
Authors: Ross Kathryn M. , Carpenter Chelsea A. , Arroyo Kelsey M. , Shankar Meena N. , Yi Fan , Qiu Peihua , Anthony Lisa , Ruiz Jaime , Perri Michael G. 
Published: January 2022

AbstractObjectiveThis study evaluated whether the transition of a face‐to‐face behavioral intervention to videoconferencing‐based telehealth delivery during the COVID‐19 pandemic resulted in significantly smaller weight losses than those typically observed in gold‐standard, face‐to‐face programs.MethodsParticipants were 160 adults with obesity (mean [SD] age = 49.2 [11.9] years, BMI = 36.1 [4.2] kg/m2) enrolled in two cohorts of a 16‐week comprehensive weight‐management program. Cohort 1 began in person and transitioned to telehealth (Zoom) delivery during week 11 of the intervention because of COVID‐19; Cohort 2 was conducted completely remotely. A noninferiority approach (using a clinically relevant noninferiority margin of 2.5%) was used to assess whether the weight losses observed were inferior to the 8% losses from baseline typically produced by gold‐standard, face‐to‐face lifestyle interventions.ResultsFrom baseline to postintervention, participants lost an average of 7.4 [4.9] kg, representing a reduction of 7.2% [4.6%]. This magnitude of weight change was significantly greater than 5.5% (t[159] = 4.7, p < 0.001), and, thus, was within the proposed noninferiority margin.ConclusionsThese findings demonstrate that the results of behavioral weight‐management interventions are robust, whether delivered in person or remotely, and that individuals can achieve clinically meaningful benefits from behavioral treatment even during a global pandemic. Pragmatic “lessons learned,” including modified trial recruitment techniques, are discussed.
The prevalence of prenatal sonographic findings in postnatal diagnostic exome sequencing performed for neurocognitive phenotypes: A cohort study
Authors: Sukenik‐Halevy Rivka , Perlman Sharon , Ruhrman‐Shahar Noa , Engel Offra , Orenstein Naama , Gonzaga‐Jauregui Claudia , Shuldiner Alan R. ,   Regeneron Genetics Center, Magal Nurit , Hagari Ofir , Azulay Noy , Lidzbarsky Gabriel Arie , Bazak Lily , Basel‐Salmon Lina 
Published: January 2022

AbstractObjectivePrenatal exome sequencing (ES) is currently indicated for fetal malformations. Some neurocognitive genetic disorders may not have a prenatal phenotype. We assessed the prevalence of prenatally detectable phenotypes among patients with neurocognitive syndromes diagnosed postnatally by ES.MethodsThe medical files of a cohort of 138 patients diagnosed postnatally with a neurocognitive disorder using ES were reviewed for prenatal sonographic data. The Online Mendelian Inheritance in Man (OMIM) database was searched for prenatally detectable phenotypes for all genes identified.ResultsPrenatal imaging data were available for 122 cases. Of these, 29 (23.75%) had fetal structural abnormalities and another 29 had other ultrasound abnormalities (fetal growth restriction, polyhydramnios, elevated nuchal translucency). In 30 patients, structural aberrations that were not diagnosed prenatally were detected at birth; in 21 (17.2%), the abnormalities could theoretically be detected prenatally by third‐trimester/targeted scans. According to OMIM, 55.9% of the diagnosed genes were not associated with structural anomalies.ConclusionsMost patients (52.5%) with postnatally diagnosed neurocognitive disorders did not have prenatal sonographic findings indicating prenatal ES should be considered. The prevalence of specific prenatal phenotypes such as fetal growth restriction and polyhydramnios in our cohort suggests that additional prenatal findings should be assessed as possible indications for prenatal ES.
A review of upper extremity peripheral nerve injuries in throwing athletes
Authors: Bowers Robert L. , Cherian Chris , Zaremski Jason L. 
Published: January 2022

AbstractPeripheral nerve injuries in the upper extremities may be common in throwing athletes as the throwing motion places extreme stress on the dominant arm. The combination of extreme stress along with repetitive microtrauma from throwing uniquely places the throwing athlete at elevated risk of upper extremity peripheral nerve injury. However, because symptoms can be nonspecific and frequently coexist with pathology in the upper extremity, the diagnosis of peripheral nerve injury is often delayed. Diagnosis of peripheral nerve injuries may require a combination of history and physical examination, diagnostic imaging, electrodiagnostic testing, and diagnostic ultrasound‐guided injections. The primary management should include physical therapy focusing on throwing mechanics and kinetic chain evaluation. However, some athletes require surgical intervention if symptoms do not improve with conservative management. The purpose of this focused narrative review is to highlight upper extremity peripheral neuropathies reported in throwing athletes and to provide an overview of the appropriate clinical diagnosis and management of the throwing athlete with a peripheral nerve injury.
Predicting post‐stroke motor recovery of upper extremity using clinical variables and performance assays: A prospective cohort study protocol
Authors: Sardesai Sanjukta , Solomon M John , Arumugam Ashokan , Guddattu Vasudeva , Gorthi Sankar Prasad , Pai Aparna , Kumaran D Senthil 
Published: January 2022

AbstractBackground and PurposeMeasurement of movement quality is essential to distinguish motor recovery patterns and optimize rehabilitation strategies post‐stroke. Recently, the Stroke Recovery and Rehabilitation Roundtable Taskforce (SRRR) recommended four kinetic and kinematic performance assays to measure upper extremity (UE) movements and distinguish behavioral restitution and compensation mechanisms early post‐stroke. The purpose of this study is to develop and validate a prediction model to analyze the added prognostic value of performance assays over clinical variables assessed up to 1‐month post stroke for predicting recovery of UE motor impairment, capacity and quality of movement (QoM) measured at 3 months post‐stroke onset.MethodsIn this prospective cohort study, 120 stroke survivors will be recruited within seven days post‐stroke. Candidate predictors such as baseline characteristics, demographics and performance assays as per SRRR recommendations along with tonic stretch reflex threshold will be measured up to 1‐month post‐stroke. Upper extremity motor recovery will be evaluated in terms of motor impairment (Fugl‐Meyer assessment for UE), UE capacity measured with Action Research Arm Test (ARAT) and QoM (movement smoothness in the form of peak metrics [PM]) assessed with a reach‐to‐grasp‐to‐mouth task (mimicking a drinking task) at 3 months post‐stroke. Three multivariable linear regression models will be developed to predict factors responsible for the outcomes of Fugl‐Meyer assessment for upper extremity (FM‐UE), ARAT and movement quality. The developed models will be internally validated using a split‐sample method.DiscussionThis study will provide a validated prediction model inclusive of clinical and performance assays that may assist in prediction of UE motor recovery. Predicting the amount of recovery and differentiating between behavioral restitution and compensation (as reflected by the FM‐UE, QoM and ARAT) would enable us in realistic goal formation and planning rehabilitation. It would also help in encouraging patients to partake in early post‐stroke rehabilitation thus improving the recovery potential.
PFAS Experts Symposium 2: PFAS Remediation research – Evolution from past to present, current efforts, and potential futures
Authors: Newell Charles J. , DiGuiseppi William H. , Cassidy Daniel P. , Divine Craig E. , Fenstermacher James M. , Hagelin Nathan W. , Thomas Ryan A. , Tomiczek Paul , Warner Scott D. , Xiong Zhong John , Hatzinger Paul B. 
Published: January 2022

AbstractDue to the diverse chemistries of per‐ and polyfluoroalkyl substances (PFAS) and their apparent recalcitrance to natural biological and abiotic transformation processes, remediation of this class of compounds in groundwater environments is much more challenging than that of other common contaminants such as chlorinated solvents, hydrocarbons, methyl tert‐butyl ether, and 1,4‐dioxane. Overall, the groundwater remediation community is faced with substantial challenges that will require both continued enhancement of existing technologies and development of new technologies and strategies to manage PFAS‐impacted sites. Fortunately, an extraordinary breadth and depth of ongoing research in PFAS remediation is funded through a variety of different agencies and organizations. This research can be organized into three main categories: (1) nondestructive approaches that remove PFAS from water and other matrices; (2) destructive technologies that break carbon–fluorine and carbon–carbon bonds to create nontoxic products; and (3) coupled systems that concentrate and then destroy PFAS. As with previous groundwater contaminants, an initial focus on ex situ PFAS treatment is now slowly evolving to include more in situ research. However, as of 2021, there are no practical groundwater remediation technologies that have been shown to destroy target PFAS (i.e., mineralize and/or create nontoxic products) in situ at full‐scale field application. While the historical goal of in situ treatment for most contaminants has been destruction, practitioners, facility owners, and regulators may need to alter their expectations and objectives for PFAS, at least in the short term, to management strategies that include treatment at receptor locations to avoid exposures and adsorption‐based attenuation strategies for some plumes. These approaches can be used as practical alternatives to PFAS destruction or to buy time until promising technologies become both commercially available and accepted by the industry. The success of any remedial effort typically depends upon meeting regulatory criteria, which in the case of PFAS, are currently in flux at the federal level and differ by orders of magnitude among state regulatory bodies. While this is understandable given the uncertainty and complexity of this issue, setting firm, consistent, and attainable regulatory standards is necessary to provide researchers and practitioners with necessary benchmarks for remediation technology development and commercialization.
Water Determination in Aromatic Sulfonyl Chlorides Using the Karl Fischer Titration Method: Scope and Limitations
Authors: Radchenko Olga B. , Radchenko Dmytro S. , Konovets Angelika I. , Grygorenko Oleksandr O. 
Published: January 2022

AbstractThe scope and limitations of the Karl Fischer titration was studied for various aromatic sulfonyl chlorides. Standard addition determination of water content was performed using p‐toluenesulfonyl chloride samples; it was confirmed that the method had high accuracy. A set of substituted aromatic sulfonyl chlorides (95 compounds) was subjected to the Karl Fischer titration in order to establish the relevance of the method depending on the compound structure. It was shown that the method gave satisfactory results and was applicable to most aromatic sulfonyl chlorides, except the compounds possessing strong electron‐withdrawing substituents.
Synthesis and In Vitro Analysis of 1‐Deoxysphingolipid Ceramide Analogues via UGI Reaction as Potential Anti‐cancer Agents
Authors: Kaur Parleen , Sihag Swati , Chauhan Monika , Dhingra Neelima , Agnihotri Navneet , Kaur Ramandeep , Singh Vasundhara 
Published: January 2022

AbstractIn the present work, a small library of few 1‐deoxysphingolipid ceramides has been designed and synthesized via an efficient UGI multicomponent reaction. The deoxy sphingosine intermediate (10) synthesized via Grignard reaction and olefin metathesis reaction was used as the amine component with cyclohexyl isocyanide and various aldehydes. The butyric acid has been used as an acid component which may turn out be an advantage due to the chemo preventive properties of the acid formed after the partial hydrolysis of the ceramide. Compounds (1‐6) has been synthesised via a short and facile route in high purity and yield. Molecular docking of all the analogues has been carried out with protein Sphingosine Kinase I using BiopredictaVlife MDS tool to determine the relative docking score and ligand‐protein interactions. Further in vitro studies were performed on PC‐3 (prostate cancer) and HCT‐116 (colon cancer) cell lines in which four compounds (1‐4) showed reasonable anti‐cancer activity against both the cell lines while compound (3) showed highest activity with IC50 value of 0.344 μM against PC‐3 (prostate cancer) cell lines and 0.624 μM against HCT‐116 (colon cancer) cell lines. Compound (4) showed IC50 value of 0.472 μM against HCT‐116 (colon cancer) cell lines.
5‐Indolylidene‐2‐iminothiazolidin‐4‐ones – Convenient Starting Compounds for Stereoselective Synthesis of Novel Dispirooxindole Derivatives
Authors: Izmest'ev Alexei N. , Streltsov Andrey A. , Karnoukhova Valentina A. , Kolotyrkina Natalya G. , Strelenko Yurii A. , Kravchenko Angelina N. , Gazieva Galina A. 
Published: January 2022

AbstractA convenient method for the synthesis of novel dispirooxindoles containing 2‐iminothiazolidin‐4‐one moiety has been proposed. The method relies on a 1,3‐dipolar cycloaddition of azomethine ylides generated in situ from paraformaldehyde and N‐alkyl amino acids including chiral ones to 5‐indolylidene‐2‐iminothiazolidin‐4‐ones. The method is suitable for preparing enantiomerically pure derivatives.
Highly selective and efficient electroreduction of CO2 in water by quaterpyridine derivative‐based molecular catalyst noncovalently tethered to carbon nanotubes
Authors: Reddu Vikas , Sun Libo , Li Xiaogang , Jin Huile , Wang Shun , Wang Xin 
Published: January 2022

AbstractA disubstituted quaterpyridine based cobalt complex non‐covalently tethered to multiwalled carbon nanotube (MWCNT) substrate, forming a hybrid catalyst, Co‐qpyCOOH/CNT, catalyzed the conversion of CO2 to CO under aqueous conditions. At an optimal and uniform loading, it exhibited remarkable catalytic activity, near‐exclusive selectivity, and high stability towards the formation of CO. At a mere cathodic potential of −0.65 V versus RHE (η = 0.54 V), it achieved a high partial current density of −6.7 mA/cm2 and a F.E.CO = 100%. In addition, with 20 h of stable operation, hydrogen evolution remained practically undetected. Its hybrid structure due to noncovalent immobilization on MWCNT imparted the intrinsic activity and much‐needed stability in performance whereas ‒COOH groups may stabilize the intermediates by acting as H‐bond donors, promoting catalytic activity. Tethering to a conductive solid substrate and tuning of the second sphere of coordination played an important role in its performance to achieve desired reduction product with high selectivity and activity.
Cross‐sectional study on the in‐herd prevalence ofMycoplasma hyopneumoniaeat different stages of pig production
Authors: Deffner Pauline , Maurer Roland , Cvjetković Vojislav , Sipos Wolfgang , Krejci Roman , Ritzmann Mathias , Eddicks Matthias 
Published: January 2022

AbstractBackgroundA cross‐sectional study was carried out to assess the prevalence ofMycoplasma hyopneumoniaeinfections before vaccination in 3‐week‐old piglets and to gain information about infection dynamics.MethodsIn 13 German and three Austrian farms with a known history of enzootic pneumonia, 790 piglets and 158 sows were sampled (blood samples, tracheobronchial swabs [TBS] [piglets], laryngeal swabs [LS] [sows]), and 525 pen‐based oral fluids (OFs) were collected in growing and fattening pigs. Laboratory diagnostics included enzyme‐linked immunosorbent assay (ELISA) and real‐time polymerase chain reaction (PCR) analyses.ResultsAntibodies toM. hyopneumoniaewere present in 87.5 per cent of all herds. Seroprevalence ranged from 0.0 to 100.0 per cent and 0.0 to 88.0 per cent in sows and piglets, respectively.M. hyopneumoniae‐deoxyribonucleic acid (DNA) was present in 3.8 and 0.4 per cent of LS and TBS, respectively. Gilts had a 10.9 times higher chance beingM. hyopneumoniaePCR‐positive than older sows. In 75.0 per cent of all farms,M. hyopneumoniae‐DNA was present in OFs. Detection rate was significantly higher in OFs of 20‐week‐old than in younger pigs (p < 0.001).ConclusionResults indicate thatM. hyopneumoniaeinfections of the lower respiratory tract in piglets are rare but highlight the role of gilts in maintaining infection in the herd. Collecting OFs seems promising for surveillance, if coughing occurs simultaneously.