bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of transfusion‐related acute lung injury temporally associated with solvent/detergent plasma use in the ICU: A retrospective before and after implementation study
Authors: Klanderman Robert B. , van Mourik Niels , Eggermont Dorus , Peters Anna‐Linda , Tuinman Pieter R. , Bosman Rob , Endeman Henrik , Cremer Olaf L. , Arbous Sesmu M. , Vlaar Alexander P. J. 
Published: August 2022

AbstractBackgroundTransfusion‐related acute lung injury (TRALI) is a severe complication of plasma transfusion, though the use of solvent/detergent pooled plasma (SDP) has nearly eliminated reported TRALI cases. The goal of this study was to investigate the incidence of TRALI in intensive care units (ICU) following the replacement of quarantined fresh frozen plasma (qFFP) by SDP.Study design and methodsA retrospective multicenter observational before–after cohort study was performed during two 6‐month periods, before (April–October 2014) and after the introduction of SDP (April–October 2015), accounting for a washout period. A full chart review was performed for patients who received ≥1 plasma units and developed hypoxemia within 24 h.ResultsDuring the study period, 8944 patients were admitted to the ICU. Exactly 1171 quarantine fresh frozen plasma (qFFP) units were transfused in 376 patients, and respectively, 2008 SDP units to 396 patients after implementation. Ten TRALI cases occurred during the qFFP and nine cases occurred during the SDP period, in which plasma was transfused. The incidence was 0.85% (CI95%: 0.33%–1.4%) per unit qFFP and 0.45% (CI95%: 0.21%–0.79%, p = 0.221) per SDP unit. One instance of TRALI occurred after a single SDP unit. Mortality was 70% for patients developing TRALI in the ICU compared with 22% in patients receiving at least one plasma transfusion.ConclusionImplementation of SDP lowered the incidence of TRALI in which plasma products were implicated, though not significantly. Clinically diagnosed TRALI can still occur following SDP transfusion. Developing TRALI in the ICU was associated with high mortality rates, therefore, clinicians should remain vigilant.
Blood donation behaviour and attitudes towards the 12‐month deferral policy among gay and bisexual men in New Zealand
Authors: Sriamporn Koson Tony , Saxton Peter , Consedine Nathan , Hammoud Mohamed , Prestage Garrett 
Published: August 2022

AbstractBackground and ObjectivesGay and bisexual men (GBM) are deferred from donating blood in many countries. Perceptions by GBM that blood donor deferral policies are unjustifiably discriminatory, especially due to advances in HIV prevention, could contribute to non‐compliance and need to be understood. We explore blood donation interest and history among GBM and attitudes towards donor deferral policies for the first time in New Zealand (NZ).Materials and MethodsData from a cross‐sectional online survey of GBM in NZ were examined. We constructed three groups: (1) never donated blood and not interested; (2) never donated but expressed interest; and (3) previously donated blood. We tested these for association with demographic and behavioural variables, as well as attitudes towards blood donation policy.ResultsA total of 607 GBM were eligible for the study, of whom 32.9% reported having donated blood previously, 44.3% had never donated blood but expressed interest and 22.7% expressed no interest in donating. Among previous donors, a third (8.6% of the total sample) reported non‐compliance with the deferral policy. Most participants found the 12‐month deferral policy to be too strict (81.8%), unfair (75.4%) and homophobic (68.8%).ConclusionWe estimate that, for the first time in NZ, almost 10% of the sample did not report compliance with the 12‐month deferral policy for men who have sex with men (MSM). Negative attitudes towards the deferral policy were common and could potentially increase the risk to the blood supply if compliance reduces. Further work is needed to inform a deferral policy that is accepted by GBM while maintaining the safety of NZ's blood supply.
A Cell Model of an Ion-Exchange Membrane. Capillary-Osmosis and Reverse-Osmosis Coefficients
Authors: Filippov A. N. 
Published: August 2022

Abstract
The capillary-osmosis and reverse-osmosis coefficients of an ion-exchange membrane have been calculated as the kinetic coefficients of the Onsager matrix within the thermodynamics of nonequilibrium processes and on the basis of the cell model proposed previously by the author for charged porous layers. The membrane is assumed to consist of an ordered set of spherical completely porous charged particles placed into spherical shells filled with a binary electrolyte solution. Boundary value problems have been analytically solved to determine the capillary-osmosis and reverse-osmosis coefficients of such a membrane under the Kuwabara boundary condition imposed on the cell surface. The consideration has been implemented within the framework of small deviations of system parameters from their equilibrium values under the action of external fields. Different particular cases of the obtained exact analytical equations have been studied including the case of a binary symmetric electrolyte and an ideally selective membrane. It has been shown that, for the considered cell model of an ion-exchange membrane, the Onsager reciprocity theorem is violated; i.e., the found kinetic cross coefficients are unequal to each other. The violation is explained by the fact that the reciprocity theorem is valid only for systems implying the linear thermodynamics of irreversible processes, for which generalized flows are equal to zero at nonzero thermodynamic forces.
Intravitreal application of epidermal growth factor in non-exudative
age-related macular degeneration
Authors: Bikbov Mukharram M , Khalimov Timur A , Panda-Jonas Songhomitra , Jonas Jost B 
Published: August 2022

Purpose
To assess the safety of intravitreally applied epidermal growth
factor (EGF).

Methods
The clinical interventional, prospective, single-centre, case series
study included patients with age-related macular degeneration-related
geographic atrophy (GA), in whom the eye with the worse best-corrected
visual acuity (BCVA) underwent a single, or repeated, intravitreal
injection of EGF (0.75 µg in 50 µL). At baseline and afterwards, the
eyes underwent ophthalmological examinations.

Results
The study included seven patients (mean age:70.0±12.2 years (range:
54–86 years), with five patients receiving a single injection and two
patients receiving two intravitreal injections in an interval of 4
weeks. Mean duration of follow-up was 97±97 days (median:35 days; range:
7–240 days). Mean BCVA was lower at baseline than at study end
(1.41±0.44 logMAR vs 0.97±0.12 logMAR; p=0.03). Mean size of the GA
lesions did not differ significantly between baseline and study end (29
212±22 887 pixels vs 29 300±22 905 pixels; p=0.59) nor did the mean
perimetric mean defect (−10.3±5.9 dB vs 12.0±8.8 dB; p=0.35) or the
electroretinographical b-wave amplitude (44.53±31.7 µV vs 64.5±25.5 µV;
p=0.12). After a second injection 4 weeks after the first injection, one
of two patients developed a cystoid macular oedema in association with
an induced incomplete posterior vitreous detachment. It persisted for 3
weeks. Visual acuity in this eye improved from 1.0 logMAR at baseline to
0.80 logMAR at study end.

Conclusions
Except for one eye with temporary, self-resolving cystoid macular
oedema, single and repeated intravitreal applications of EGF (0.75 µg)
in patients with GA did not lead to intraocular inflammations or any
observed intraocular side effect.

Trial registration number
NCT12733334.
Effect on bone anabolic markers of daily cheese intake with and without vitamin K2: a randomised clinical trial
Authors: Lundberg Helge Einar , Glasø Morten , Chhura Rahul , Shukla Arjun Andre , Austlid Torunn , Sarwar Zohaib , Hovland Kathrine , Iqbal Sapna , Fagertun Hans Erik , Holo Helge , Larsen Stig Einride 
Published: August 2022

BackgroundDaily intake of 57 g Jarlsberg cheese has been shown to increase the total serum osteocalcin (tOC). Is this a general cheese effect or specific for Jarlsberg containing vitamin K2and 1,4-dihydroxy-2naphtoic acid (DHNA)?Methods66 healthy female volunteers (HV) were recruited. By skewed randomisation (3:2), 41 HV were allocated to daily intake of 57 g Jarlsberg (J-group) and 25–50 g Camembert (C-group) in 6 weeks. After 6 weeks the C-group was switched to Jarlsberg. The study duration was 12 weeks with clinical investigations every 6 weeks. The main variables were procollagen type 1 N-terminal propeptide (PINP), tOC, carboxylated osteocalcin (cOC) and the osteocalcin ratio (RO) defined as the ratio between cOC and undercarboxylated osteocalcin (ucOC). Serum cross-linked C-telopeptide type I collagen (CTX), vitamin K2, lipids and clinical chemistry were used as secondary variables.ResultsPINP, tOC, cOC, ROand vitamin K2increased significantly (p<0.01) after 6 weeks in the J-group. PINP remained unchanged in the C-group. The other variables decreased slightly in the C-group but increased significantly (p≤0.05) after switching to Jarlsberg. No CTX-changes detected in neither of the groups.Serum lipids increased slightly in both groups. Switching to Jarlsberg, total cholesterol and low-density lipoprotein-cholesterol were significantly reduced (p≤0.05). Glycated haemoglobin (HbA1c), Ca++and Mg++were significantly reduced in the J-group, but unchanged in the C-group. Switching to Jarlsberg, HbA1c and Ca++decreased significantly.ConclusionThe effect of daily Jarlsberg intake on increased s-osteocalcin level is not a general cheese effect. Jarlsberg contain vitamin K2and DHNA which increases PINP, tOC, cOC and ROand decreases Ca++, Mg++and HbA1c. These effects reflect increased bone anabolism and a possible reduced risk of adverse metabolic outcomes.Trial registration numberNCT04189796.
Cooled and traditional thermal radiofrequency ablation of genicular nerves in patients with chronic knee pain: a comparative outcomes analysis
Authors: Wu Bernie P , Grits Daniel , Foorsov Victor , Xu Jijun , Tankha Pavan , Bolash Robert B 
Published: August 2022

IntroductionGenicular nerve radiofrequency ablation (GNRFA) is a minimally invasive intervention for patients with chronic knee pain (CKP) not responding to conservative treatments. Few investigations have compared treatment outcomes of cooled-RFA (c-RFA) and thermal-RFA (t-RFA), two common approaches of GNRFA. This study aims to investigate and compare outcomes, including probability of treatment success, between c-RFA and t-RFA in patients with CKP.MethodsThis retrospective cohort study analyzed a total of 208 propensity score matched patients, including 104 patients who received c-RFA and 104 patients who received t-RFA. The primary outcome was probability of pain relief after the procedure, defined as reduction in Numeric Rating Scale (NRS) pain score of 2 or greater. The secondary outcomes were degree of NRS pain score reductions, duration of relief, and the probability of patients receiving TKA within 1 year of treatment.ResultsT-RFA was associated with a higher probability of pain relief within 1, 3, and 6 months after procedure when compared with c-RFA. Probabilities of pain relief from t-RFA and c-RFA were 62% (95% CI 51% to 71%) and 43% (95% CI 34% to 53%; p=0.01) within 1 month, 78% (95% CI 68% to 85%) and 55% (95% CI 45% to 64%; p<0.001) within 3 months, and 79% (95% CI 70% to 86%) and 59% (95% CI 49% to 68%; p<0.01) within 6 months, respectively. t-RFA was also associated with greater mean NRS pain score reduction at 1 month after procedure: −4.71 (95% CI −5.3 to −4.1) when compared with −3.59 (95% CI −4.3 to −2.9; p=0.02) from c-RFA. T-RFA and c-RFA were comparable in pain score reduction at 3, 6, 9 and 12 months after procedure. Both groups demonstrated comparable duration of relief and probability of patients receiving TKA within 1 year.DiscussionBoth t-RFA and c-RFA effectively reduced NRS pain scores in most patients with CKP within the 1 year follow-up period. Genicular nerve t-RFA was associated with a higher probability of treatment success and a greater degree of pain relief at 1 month after the procedure when compared with c-RFA in propensity score matched patients with CKP.
Antithrombotic drugs and the risk of bloody punctures in regional anesthesia - a retrospective registry analysis
Authors: Kubulus Christine , Gürtesch Christine A , Wagenpfeil Gudrun , Sessler Daniel I , Volk Thomas 
Published: August 2022

IntroductionThe risk of bleeding during regional anesthesia implementation in patients on antithrombotic therapy remains poorly characterized. We; therefore, analyzed bloody tap rates and adjusted ORs comparing patients who take antithrombotic medications with those who do not.Methods65,814 qualifying regional anesthetics (2007–2019) from the Network for Safety in Regional Anesthesia and Acute Pain Therapy registry were included in a retrospective cohort analysis. Procedures in patients who took antithrombotic drugs were compared with procedures in patients who did not. The primary outcome was bloody puncture, defined as any kind of blood aspiration during placement. Secondarily, we considered timely discontinuation of thromboprophylaxis and the impact of various drug classes. As a sensitivity analysis, we used propensity matched groups.ResultsPatients on antithrombotic therapy were more likely to have a bloody puncture during peripheral nerve block implementation (adjusted OR 1.60; 95% CI 1.33 to 1.93; p<0.001) irrespective of whether therapy was discontinued. In contrast, bloody neuraxial blocks were no more common in patients who took antithrombotic medications (adjusted OR 0.95; 95% CI 0.82 to 1.10; p=0.523) so long as they were paused per guideline. Across both peripheral and neuraxial blocks, concurrent use of more than one platelet and/or coagulation cascade inhibitor nearly doubled the odds (adjusted OR, 1.89; 95% CI 1.48 to 2.40; p<0.001).DiscussionPatients on antithrombotic therapy receiving peripheral blocks are at increased risk for bloody punctures irrespective of discontinuation practice. Patients having neuraxial blocks are not at increased risk so long as antithrombotics are stopped per guidelines. Patients who take combined medications are at especially high risk. Guidelines for discontinuing antithrombotic treatments for neuraxial anesthesia appear to be effective and should possibly be extended to high-risk peripheral blocks.
How do advance regeneration and planted seedlings of Thuja occidentalis and Picea rubens acclimate under a first irregular shelterwood cut?
Authors: Bourque Claudelle , Dumais Daniel , Ruel Jean-Claude , Larouche Catherine , Raymond Patricia 
Published: August 2022

Eastern white cedar ( Thuja occidentalis) and red spruce ( Picea rubens) contribute to the biodiversity and resilience of mixedwood forests. However, cuts that remove most or all the forest cover can cause the decline of these species. Among partial cutting options, the irregular shelterwood system (ISS) can create successful conditions for the development of advance regeneration and enrichment planting. We studied 6 years of ecophysiology of lower advance regeneration and planted seedlings of eastern white cedar and red spruce growing under a first ISS cut according to three cutting intensities: light cut (35% removal, 20 m2·ha−1 residual basal area), moderate cut (42%, 18 m2·ha−1), and heavy cut (52%, 15 m2·ha−1). Light-saturated photosynthesis and height growth of planted cedar and both spruce types decreased with increasing cutting intensity, in response to an increase in competing vegetation. Therefore, to limit the negative impact of competing species on cedar and spruce regeneration, we recommend protecting tall advance regeneration (2 m+) during partial cut operations and using large-sized containerized seedlings (40–50 cm height) for enrichment planting. Results also suggest that a mechanical release could help optimize the physio-morphology and growth of both regeneration types of cedar and red spruce.
Loop-corrected Higgs masses in the NMSSM with inverse seesaw mechanism
Authors: Dao Thi Nhung , Mühlleitner Margarete , Phan Anh Vu 
Published: August 2022

AbstractIn this study, we work in the framework of the Next-to-Minimal extension of the Standard Model (NMSSM) extended by six singlet leptonic superfields. Through the mixing with the three doublet leptonic superfields, the non-zero tiny neutrino masses can be generated through the inverse seesaw mechanism. While R-parity is conserved in this model lepton number is explicitly violated. We quantify the impact of the extended neutrino sector on the NMSSM Higgs sector by computing the complete one-loop corrections with full momentum dependence to the Higgs boson masses in a mixed on-shell-$$\overline{\text{ DR }}$$

DR

¯

renormalization scheme, with and without the inclusion of CP violation. The results are consistently combined with the dominant two-loop corrections at $$\mathcal{O}(\alpha _t(\alpha _s+\alpha _t))$$

O
(

α
t

(

α
s

+

α
t

)

)

to improve the predictions for the Higgs mixing and the loop-corrected masses. In our numerical study we include the constraints from the Higgs data, the neutrino oscillation data, the charged lepton flavor-violating decays $$l_i \rightarrow l_j + \gamma $$

l
i

→

l
j

+
γ

, and the new physics constraints from the oblique parameters S, T, U. We present in this context the one-loop decay width for $$l_i \rightarrow l_j + \gamma $$

l
i

→

l
j

+
γ

. The loop-corrected Higgs boson masses are included in the Fortran code .
Improved tests of entanglement and Bell inequalities with LHC tops
Authors: Aguilar-Saavedra J. A. , Casas J. A. 
Published: August 2022

AbstractWe discuss quantum entanglement in top pair production at the LHC. Near the $$t {\bar{t}}$$

t

t

¯

threshold, entanglement observables are enhanced by suppressing the contribution of $$q {\bar{q}}$$

q

q

¯

subprocesses, which is achieved by a simple cut on the velocity of the $$t {\bar{t}}$$

t

t

¯

system in the laboratory frame. Furthermore, we design new observables that directly measure the relevant combinations of $$t{\bar{t}}$$

t

t

¯

spin correlation coefficients involved in the measurement of entanglement and Bell inequalities. As a result, the statistical sensitivity is enhanced, up to a factor of 7 for Bell inequalities near threshold.
Quasibound states of scalar fields in the consistent 4D Einstein–Gauss–Bonnet–(Anti-)de Sitter gravity
Authors: Vieira H. S. , Bezerra V. B. , Muniz C. R. , Cunha M. S. 
Published: August 2022

AbstractWe examine the interaction between massless scalar fields and the gravitational field generated by a black hole solution that was recently obtained in the consistent well-defined 4-dimensional Einstein–Gauss–Bonnet gravity with a cosmological constant. In order to do this, we calculate quasibound state frequencies of scalar fields for the spherically symmetric black hole in the consistent 4-dimensional Einstein–Gauss–Bonnet–de Sitter and Anti-de Sitter theories. The expression for the quasibound states is obtained by using the polynomial condition associated to the Heun functions, and their values are overdamped. We also demonstrate the stability of the systems.
Taming Molecular Field-Coupling for Nanocomputing Design
Authors: Ardesi Yuri , Garlando Umberto , Riente Fabrizio , Beretta Giuliana , Piccinini Gianluca , Graziano Mariagrazia 
Published: August 2022

Molecular Field-Coupling Nanocomputing (FCN) is one of the most promising technologies for overcoming Complementary Metal Oxide Semiconductor (CMOS) scaling issues. It encodes the information in the charge distribution of nanometric molecules and propagates it through local electrostatic intermolecular interaction. This technology promises very high speed at ambient temperatures with minimal power dissipation. The main research focus on molecular FCN is currently either on single-molecule low-level analysis or circuit design based on naïve assumptions. We aim to fill this gap, assessing the potential and feasibility of FCN. We present a bottom-up analysis and design framework that starts from the physical characterization of molecular and technological parameters and enables physical-aware FCN designs. The framework explicitly considers molecular physics, allowing the designer to tame the molecular interaction to ensure the computational capabilities of the final device. The framework permits studying possible physical effects that create cross-implications and correlations among physical and system-level layers considering possible behavior variability. We characterize and verify molecular propagation in increasingly structured layouts to design complex arithmetic circuits. The results highlight molecular FCN advantages, especially in area occupation, and provide valuable quantitative feedback to designers and technologists to support the assessment of molecular FCN and the realization of an eventual prototype.
An Active Learning Framework Improves Tumor Variant Interpretation
Authors: Blee Alexandra M. , Li Bian , Pecen Turner , Meiler Jens , Nagel Zachary D. , Capra John A. , Chazin Walter J. 
Published: August 2022

Abstract
For precision medicine to reach its full potential for treatment of cancer and other diseases, protein variant effect prediction tools are needed to characterize variants of unknown significance (VUS) in a patient's genome with respect to their likelihood to influence treatment response and outcomes. However, the performance of most variant prediction tools is limited by the difficulty of acquiring sufficient training and validation data. To overcome these limitations, we applied an iterative active learning approach starting from available biochemical, evolutionary, and functional annotations. With active learning, VUS that are most challenging to classify by an initial machine learning model are functionally evaluated and then reincorporated with the phenotype information in subsequent iterations of algorithm training. The potential of active learning to improve variant interpretation was first demonstrated by applying it to synthetic and deep mutational scanning datasets for four cancer-relevant proteins. The utility of the approach to guide interpretation and functional validation of tumor VUS was then probed on the nucleotide excision repair (NER) protein xeroderma pigmentosum complementation group A (XPA), a potential biomarker for cancer therapy sensitivity. A quantitative high-throughput cell-based NER activity assay was used to validate XPA VUS selected by the active learning strategy. In all cases, active learning yielded a significant improvement in variant effect predictions over traditional learning. These analyses suggest that active learning is well suited to significantly improve interpretation of VUS and cancer patient genomes.

Significance:
A novel machine learning approach predicts the impact of tumor mutations on cellular phenotypes, overcomes limited training data, minimizes costly functional validation, and advances efforts to implement cancer precision medicine.