bluuebunny/crossref_metadata_2025_split huggingface dataset:
Методичний підхід щодо уніфікованої оцінки ступеня професійної придатності військовозобов’язаних
Authors: Bodnar Oleh , Pampukha Ihor , Kharabara Volodymyr , Bilyk Oleksandr 
Published: November 2022

Мета роботи: Обґрунтувати застосування універсальної вербально-числової шкали Харрінгтона для уніфікації професійного відбору резервістів на посади відповідно до ВОС та розробки вирішального правила оцінки професійної придатності.
Метод: використані загальнонаукові методи аналізу та синтезу.
Теоретична цінність дослідження: основними результатами дослідження за тематикою статті є уніфікація оцінки ступеня професійної придатності військовозобов’язаних, яка полягає у заміні різнорідних вимірювальних шкал універсальною шкалою, на якій кількісні значення будь-яких особистих якостей поєднані з його якісною оцінкою та допускається аналітична згортка різних параметрів в узагальнений показник професійної придатності військовозобов’язаного.
Практична цінність дослідження: запропонований методичний підхід дозволяє оцінити рівень придатності військовозобов’язаного за кожним показником особистих якостей.
Цінність дослідження: використовуючи зазначену методику, суб’єкти які відповідають за відбір та призначення військовозобов’язаних на посади за відповідною ВОС отримують можливість провести необхідні числові розрахунки та надати обґрунтовані пропозиції керівникам військових організаційних структур що до подальшого прийняття кадрового рішення.
Проблеми взаємодії органів державної влади та суддівського врядування з іншими державними органами та установами системи правосуддя
Authors: Теремецький В. І. 
Published: November 2022

© Теремецький В. І., 2022

Інтеграція України до ЄС і світового співтовариства, потреба в удосконаленні законодавства відповідно до європейських і міжнародних стандартів, побудова ефективної та незалежної судової системи підвищують актуальність досліджень у сфері взаємодії як органів державної влади, так і в межах системи правосуддя. Аналіз чинного законодавства свідчить про існування в системі судової влади численних органів та установ, наділених управлінськими, контрольними, організаційними чи самоврядними повноваженнями. Встановлено, що перманентне корегування законодавства у сфері судочинства та судоустрою інколи призводить до дублювання повноважень (наприклад, Вищої ради правосуддя та Вищої кваліфікаційної комісії) або до необґрунтованої передачі повноважень від одного органу до іншого (наприклад, від Державної судової адміністрації України до Вищої ради правосуддя). Тому особливої актуальності набувають питання взаємодії органів державної влади та суддівського врядування з іншими державними органами та установами системи правосуддя, проблеми розмежування їх повноважень на підставі аналізу їх функцій і завдань. Доведено, що взаємодія органів державної влади та суддівського врядування з іншими державними органами та установами системи правосуддя здійснюється в таких напрямах: 1) фінансове забезпечення та бюджетування; 2) кадрова політика; 3) організаційне забезпечення діяльності судів, органів та установ системи правосуддя; 4) створення умов для ефективної діяльності судів, органів та установ системи правосуддя; 5) правозастосовна діяльність щодо виконання рішень про утворення чи припинення (ліквідацію) судів. Охарактеризовано органи та установи, які беруть активну участь у реалізації всіх напрямів взаємодії задля належного функціонування судової системи. Наголошено, що від ефективності взаємодії органів державної влади та суддівського врядування з іншими державними органами та установами системи правосуддя залежить належне функціонування судової системи як такої, створення відповідних умов для здійснення незалежного правосуддя і захисту прав та інтересів громадян, а також підвищення рівня їхньої довіри до національної системи судочинства.
THE EFFECT OF CITRATE ACID ON THE PRODUCTION PERFORMANCE OF THE QUAIL (Coturnix coturnix japonica)
Authors: Ardianto Roy , Pagala Muhammad Amrullah , Has Hamdan 
Published: November 2022

This study was aimed to determine the effect of citric acid on layer quail (Coturnix coturnix japonica) of production performance. The material used in this study was 80 quail of layer period (12 weeks) observed kept for five weeks. This study was used to complete randomized design with four treatments and five replications. Levels of citric acid administration were 0%, 0,3%, 0,6% and 0,9%, respectively. Parameters observed were feed consumption, egg production, egg weight, and feed conversion. The results showed that citric acid did not have a significant effect (P> 0,05) on feed consumption and quail egg weight, but gave real effect (P<0,05) to quail egg production and gave very significant effect (P<0,01) to feed conversion of quail. The addition of citric acid with a level of 0,6% (P2) gives better egg production and feed conversion than other treatments. Keywords: Quail, Citric Acid, Production Performance
Analisis Permintaan Beras Merah di Kota Baubau
Authors: Iksan Muhamad , Taridala Sitti Aida Adha , Budiyanto Budiyanto 
Published: November 2022

The aim of this study is to analyze the factors that influence the demand for red rice at the household level, and to analyze the degree of sensitivity of the factors that influence the demand for brown rice. The study was conducted in Baubau City from September 2019 to January 2020. The study population was households consuming brown rice. The sample was determined using accidental sampling technique. The number of samples selected was 45 households. Data analysis used multiple non-linear regression. The results showed that the variables of household income, number of household members, housewife education, age and taste all affected the demand for brown rice. Household income, housewife education, age, and taste have a significant effect on the demand for brown rice. The variables that most dominantly affect the demand for brown rice are the number of household members who like brown rice, the degree of sensitivity to changes in household income variables, the education of housewives, age and number of household members who like brown rice are inelastic.Keywords: brown rice; household; demand; Baubau
SISTEM KOMUNIKASI PEMASARAN DALAM UPAYA MENINGKATKAN PENGGUNA WISATA NAYA MATAHORA ISLAND RESORT DI KECAMATAN WANGI-WANGI KABUPATEN WAKATOBI
Authors: Risnawati Risnawati , Lawelle Sjamsu Alam , Mansyur Akhmad 
Published: November 2022

This study aims to determine the marketing communication system in an effort to increase tourism users of Naya Matahora Island Resort in Wangi-Wangi District, Wakatobi Regency. This research was conducted at Naya Matahora Island Resort in January - February 2021. Data collection was done by interview, observation, documentation and literature study. The method used in determining respondents is purposive and accidental sampling. The number of samples was 16 people, consisting of 1 tourist manager, 10 tourist users and 5 prospective tourist users. The analysis used is descriptive qualitative analysis. The results of the study concluded that the communication system used to market Naya Matahora Island Resort tourism was by utilizing a marketing mix such as advertising through social media (instagram) and brochures offered to government agencies, sales promotion by providing promo prices and direct selling. However, the promotional communication system carried out through social media is less than optimal so it does not affect the increase in tourist users. The increase in the number of users from 155 people to 534 people was dominated by local tourism users who were only interested in using the swimming pool and enjoying food at the Naya Matahora restaurant. To increase tourism users, the manager should promote their tourism using social media, so that tourism marketing can reach a wider market. Keywords : Naya Matahora, Marketing Communication System, Promotion
PEMBINAAN BUDI PEKERTI DALAM PEMBELAJARAN PPKn PADA SISWA DI MTs PESRI UMMUSABRI KENDARI
Authors: Harun Harun , Muh. Yusuf Muh. Yusuf , Darnawati Darnawati 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui dan menganalisis:1) pembinaan budi pekerti dalam pembelajaran PPKn pada siswa; 2) faktor-faktor yang menghambat pembinaan budi pekerti dalam pembelajaran PPKn pada siswa; 3) faktor-faktor yang mendukung pembinaan budi pekerti dalam pembelajaran PPKn pada siswa. Pendektan penelitian ini bersifat kualitatif. Subjek penelitian ini yaitu Kepala Sekolah, Wakil Kepala Sekolah Kesiswaan, Guru PPKn, Guru Bimbingan Konseling, dan 15 Siswa. Pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Hasil penelitian: 1) pembinaan budi pekerti dalam pembelajaran PPKn pada siswa di MTs Pesri Ummusabri Kendari sudah berjalan dengan baik. 2) faktor penghambat pembinaan Pembinaan budi pekerti dalam pembelajaran PPKn pada siswa MTs Pesri Ummusabri Kendari yaitu faktor dari diri siswa yang belum siap untuk belajar dan faktor lingkungan keluarga yang kurang baik. 3) faktor pendukung adanya kelengkapan sarana prasarana, sumber daya manusia, sistem informasi madrasah, perekrutan guru-guru sesuai dengan kebutuhan, madrasah memfasilitasi, mendukung selurunya yang di butuhkan guru.Kata Kunci: Budi Pekerti; PPKn
Analysis Of Processed Cash Product Development Using Quality Function Deploment (QFD) Method In UD. Mete Mubaraq Lombe Kendari City
Authors: Febriani Febriani , Sarinah Sarinah , Syukri Muhammad 
Published: November 2022

This study aims to determine the process of developing cashew products using the Quality Function Deployment (QFD) method at UD. Cashew Mubaraq Lombe Kendari City. Determination of the research location purposively. Data was collected using observation, questionnaires, interviews, and documentation. Theanalytical method used is Quality Function Deployment (QFD). The results showed the development of cashew products at UD. Mubaraq Lombe cashew using the QFD method, it was found that the priorities to be developed in accordance with the wishes and needs of consumers in a row include: (1) the selling price ofcashew products is affordable (8.430%), (2) sales discounts on certain days (7.686%) , (3) discounted cashew product purchases (7.270%), (4) cashew product sales online (6.822%), (5) easy to get cashew products (6.623%), (6) does not contain preservatives (6.567%) , (7) good product quality (6,435%), (8) product taste (6,410%), (9) information on nutritional value on cashew product packaging (6,384%), (10) price match with product quality (8,430%) , (11) there is a certificate of permission from the Ministry of Health (department of health) for cashew products (6.255%), (12) there are halal certificates and labels for cashew products (6.230%), (13) information on expiration (expiration date) (6.229%), (14 ) various types of cashew products (6,227%), and (15) attractive product packaging designs (6,152%).
Pharmacogenomics driven decision support prototype with machine learning: A framework for improving patient care
Authors: Kidwai-Khan Farah , Rentsch Christopher T. , Pulk Rebecca , Alcorn Charles , Brandt Cynthia A. , Justice Amy C. 
Published: November 2022

IntroductionA growing number of healthcare providers make complex treatment decisions guided by electronic health record (EHR) software interfaces. Many interfaces integrate multiple sources of data (e.g., labs, pharmacy, diagnoses) successfully, though relatively few have incorporated genetic data.MethodThis study utilizes informatics methods with predictive modeling to create and validate algorithms to enable informed pharmacogenomic decision-making at the point of care in near real-time. The proposed framework integrates EHR and genetic data relevant to the patient's current medications including decision support mechanisms based on predictive modeling. We created a prototype with EHR and linked genetic data from the Department of Veterans Affairs (VA), the largest integrated healthcare system in the US. The EHR data included diagnoses, medication fills, and outpatient clinic visits for 2,600 people with HIV and matched uninfected controls linked to prototypic genetic data (variations in single or multiple positions in the DNA sequence). We then mapped the medications that patients were prescribed to medications defined in the drug-gene interaction mapping of the Clinical Pharmacogenomics Implementation Consortium's (CPIC) level A (i.e., sufficient evidence for at least one prescribing action) guidelines that predict adverse events. CPIC is a National Institute of Health funded group of experts who develop evidence based pharmacogenomic guidelines. Preventable adverse events (PAE) can be defined as a harmful outcome from an intervention that could have been prevented. For this study, we focused on potential PAEs resulting from a medication-gene interaction.ResultsThe final model showed AUC scores of 0.972 with an F1 score of 0.97 with genetic data as compared to 0.766 and 0.73 respectively, without genetic data integration.DiscussionOver 98% of people in the cohort were on at least one medication with CPIC level a guideline in their lifetime. We compared predictive power of machine learning models to detect a PAE between five modeling methods: Random Forest, Support Vector Machine (SVM), Extreme Gradient Boosting (XGBoost), K Nearest neighbors (KNN), and Decision Tree. We found that XGBoost performed best for the prototype when genetic data was added to the framework and improved prediction of PAE. We compared area under the curve (AUC) between the models in the testing dataset.
Construction of a potentially functional lncRNA-miRNA-mRNA network in sepsis by bioinformatics analysis
Authors: Zheng Li-ming , Ye Jun-qiu , Li Heng-fei , Liu Quan 
Published: November 2022

Objective: Sepsis is a common disease in internal medicine, with a high incidence and dangerous condition. Due to the limited understanding of its pathogenesis, the prognosis is poor. The goal of this project is to screen potential biomarkers for the diagnosis of sepsis and to identify competitive endogenous RNA (ceRNA) networks associated with sepsis.Methods: The expression profiles of long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and messenger RNAs (mRNAs) were derived from the Gene Expression Omnibus (GEO) dataset. The differentially expressed lncRNAs (DElncRNAs), miRNAs (DEmiRNAs) and mRNAs (DEmRNAs) were screened by bioinformatics analysis. DEmRNAs were analyzed by protein-protein interaction (PPI) network analysis, transcription factor enrichment analysis, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and Gene Set Enrichment Analysis (GSEA). After the prediction of the relevant database, the competitive ceRNA network is built in Cytoscape. The gene-drug interaction was predicted by DGIgb. Finally, quantitative real-time polymerase chain reaction (qRT-PCR) was used to confirm five lncRNAs from the ceRNA network.Results: Through Venn diagram analysis, we found that 57 DElncRNAs, 6 DEmiRNAs and 317 DEmRNAs expressed abnormally in patients with sepsis. GO analysis and KEGG pathway analysis showed that 789 GO terms and 36 KEGG pathways were enriched. Through intersection analysis and data mining, 5 key KEGG pathways and related core genes were revealed by GSEA. The PPI network consists of 247 nodes and 1,163 edges, and 50 hub genes are screened by the MCODE plug-in. In addition, there are 5 DElncRNAs, 6 DEmiRNAs and 28 DEmRNAs in the ceRNA network. Drug action analysis showed that 7 genes were predicted to be molecular targets of drugs. Five lncRNAs in ceRNA network are verified by qRT-PCR, and the results showed that the relative expression of five lncRNAs was significantly different between sepsis patients and healthy control subjects.Conclusion: A sepsis-specific ceRNA network has been effectively created, which is helpful to understand the interaction between lncRNAs, miRNAs and mRNAs. We discovered prospective sepsis peripheral blood indicators and proposed potential treatment medicines, providing new insights into the progression and development of sepsis.
Differentially expressed tRNA-derived fragments in bovine fetuses with assisted reproduction induced congenital overgrowth syndrome
Authors: Goldkamp Anna K. , Li Yahan , Rivera Rocio M. , Hagen Darren E. 
Published: November 2022

Background: As couples struggle with infertility and livestock producers wish to rapidly improve genetic merit in their herd, assisted reproductive technologies (ART) have become increasingly popular in human medicine as well as the livestock industry. Utilizing ART can cause an increased risk of congenital overgrowth syndromes, such as Large Offspring Syndrome (LOS) in ruminants. A dysregulation of transcripts has been observed in bovine fetuses with LOS, which is suggested to be a cause of the phenotype. Our recent study identified variations in tRNA expression in LOS individuals, leading us to hypothesize that variations in tRNA expression can influence the availability of their processed regulatory products, tRNA-derived fragments (tRFs). Due to their resemblance in size to microRNAs, studies suggest that tRFs target mRNA transcripts and regulate gene expression. Thus, we have sequenced small RNA isolated from skeletal muscle and liver of day 105 bovine fetuses to elucidate the mechanisms contributing to LOS. Moreover, we have utilized our previously generated tRNA sequencing data to analyze the contribution of tRNA availability to tRF abundance.Results: 22,289 and 7,737 unique tRFs were predicted in the liver and muscle tissue respectively. The greatest number of reads originated from 5′ tRFs in muscle and 5′ halves in liver. In addition, mitochondrial (MT) and nuclear derived tRF expression was tissue-specific with most MT-tRFs and nuclear tRFs derived from LysUUU and iMetCAU in muscle, and AsnGUU and GlyGCC in liver. Despite variation in tRF abundance within treatment groups, we identified differentially expressed (DE) tRFs across Control-AI, ART-Normal, and ART-LOS groups with the most DE tRFs between ART-Normal and ART-LOS groups. Many DE tRFs target transcripts enriched in pathways related to growth and development in the muscle and tumor development in the liver. Finally, we found positive correlation coefficients between tRNA availability and tRF expression in muscle (R = 0.47) and liver (0.6).Conclusion: Our results highlight the dysregulation of tRF expression and its regulatory roles in LOS. These tRFs were found to target both imprinted and non-imprinted genes in muscle as well as genes linked to tumor development in the liver. Furthermore, we found that tRNA transcription is a highly modulated event that plays a part in the biogenesis of tRFs. This study is the first to investigate the relationship between tRNA and tRF expression in combination with ART-induced LOS.
Constrast-enhanced computed tomography radiomics predicts CD27 expression and clinical prognosis in head and neck squamous cell carcinoma
Authors: Wang Fang , Zhang Wenhao , Chai Ying , Wang Hanshao , Liu Zhonglong , He Yue 
Published: November 2022

ObjectiveThis study aimed to construct a radiomics model that predicts the expression level of CD27 in patients with head and neck squamous cell carcinoma (HNSCC).Materials and methodsGenomic data and contrast-enhanced computed tomography (CT) images of patients with HNSCC were downloaded from the Cancer Genome Atlas and Cancer Imaging Archive for prognosis analysis, image feature extraction, and model construction. We explored the potential molecular mechanisms underlying CD27 expression and its relationship with the immune microenvironment and predicted CD27 mRNA expression in HNSCC tissues. Using non-invasive, CT-based radiomics technology, we generated a radiomics model and evaluated its correlation with the related genes and HNSCC prognosis.Results and conclusionThe expression level of CD27 in HNSCC may significantly influence the prognosis of patients with HNSCC. Radiomics based on contrast-enhanced CT is potentially effective in predicting the expression level of CD27.
Case report: The remarkable response of pembrolizumab combined with RC48 in the third-line treatment of metastatic urothelial carcinoma
Authors: Xu Zhenying , Ma Jiaman , Chen Ting , Yang Yu 
Published: November 2022

BackgroundSystemic chemotherapy has been the mainstay treatment for locally advanced or metastatic urothelial carcinoma (UC). In the past few years, novel immune checkpoint inhibitors (ICIs) and antibody-drug conjugates (ADCs) have improved the treatment of advanced UC.Case presentationHere, we report systemic therapy of a 68-year-old male diagnosed with HER2 positive (immunohistochemistry 3+), programmed cell death ligand 1(PD-L1) negative metastatic UC, and renal insufficiency. He had encountered numerous metastases and failed first-line platinum-based chemotherapy and second-line treatment with pembrolizumab and trastuzumab. During third-line treatment with RC48 (a HER2 targeting ADC) combined with pembrolizumab, he achieved a rapid partial response (PR) in the first evaluation and subsequent complete response (CR) on PET/CT and long-term progression-free survival (&gt;12 months) at the last follow-up on 25 August 2022. There are no grade 3 or 4 adverse events or aggravations of renal insufficiency during the third-line therapy.DiscussionRC48 combined with pembrolizumab demonstrated outstanding efficacy and safety in this HER2-positive metastatic UC patient. ADC combined with ICI is a promising anti-tumor strategy that deserves further exploration in advanced UC.
The prevalence, comorbidities, influencing factors, and identifying factors of non-obese fatty liver disease
Authors: Gao Ning , Deng Jiang , Wang Jinhai , Zhou Zhihua , Yao Cong , Zhou Mimi , Xing Xin , Wang Qian , Lu Xiaolan , Shi Haitao 
Published: November 2022

ObjectiveTo analyze the prevalence, associated comorbidities, influencing factors, and identifying factors of non-obese fatty liver disease and to provide a reference for its prevention and treatment.Materials and methodsFirstly, to screen data obtained from the physical examinations of individuals conducted in the Second Affiliated Hospital of Xi’an Jiaotong University in 2021, subjects with complete data of abdominal ultrasonography, body mass index, age and sex were selected to analyze the prevalence of fatty liver disease and non-obese fatty liver disease. Secondly, to screen non-obese subjects who had data for triglycerides, fasting blood glucose, and so on, to analyze the complications, influencing factors, and identifying factors of non-obese fatty liver disease.ResultsThe prevalence of fatty liver disease was 27.8% (18,416/66,221), including 33.9% (11,921/35,131) in males and 20.9% (6,495/31,090) in females, revealing that the prevalence was significantly higher in males than in females (P &lt; 0.001). There were 40,673 non-obese subjects screened in total, and the prevalence of non-obese fatty liver disease was 13.0% (5,307/40,673). The prevalence of non-obese fatty liver disease was 13.3% (2,208/16,572) in males and 12.9% (3,099/24,101) in females; the difference was not statistically significant (P = 0.17). The serum triglycerides level was elevated in 54.2% of subjects with non-obese fatty liver disease, and this was the most common abnormal metabolic index accompanying the disease. Logistic regression analysis showed that gender, age, body mass index, blood pressure, alanine aminotransferase, aspartate aminotransferase, fasting blood glucose, triglycerides, total cholesterol, and serum uric acid were independent risk factors for non-obese fatty liver disease (P &lt; 0.001). For triglycerides, the area under the receiver operating characteristic curve in predicting non-obese fatty liver disease was the greatest (0.806).ConclusionThe prevalence of fatty liver disease and non-obese fatty liver disease determined by the physical examination of individuals was high, and the triglycerides is likely to be useful for the extensive screening of non-obese fatty liver disease.