bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Impacts of Indian Ocean Sea Surface Temperature on the Dry/Wet Variations Over Northwest China
Authors: Wang Shanshan , Huang Jianping , Huang Gang , Luo Fu , Ren Yulong , He Yongli 
Published: June 2022

AbstractMost western Northwest China (WNWC) has experienced notable wetting in recent decades. Despite the widespread attention of scientific community, the causes of such climate shift are still not well‐understood. In this study, we find that the dominant mode of Indian Ocean sea surface temperature variability — Indian Ocean Basin mode (IOBM) plays a crucial role in the precipitation over WNWC. Nonetheless, such a close lagged relationship is unstable, and varies with Pacific Decadal Oscillation (PDO). When the PDO is in its warm phase, there is no robust lagged relationship between April‐June WNWC precipitation variations and January‐March IOBM. When the PDO is in its cold phase, the warm phase of the IOBM inspires a wavetrain across the Eurasian continent in the next April‐June, with an uncommon low pressure around Lake Baikal, thereby enhancing the westerlies and thus more moisture into the WNWC region. This enables the IOBM‐based statistical rainfall prediction scheme to estimate the precipitation in the WNWC region with some confidence. This remarkable contrast in the influence of IOBM between the two phases of the PDO highlights exciting new avenues for improving climate predictions over the WNWC.
Multi‐Stage Soil‐Hydraulic Recovery and Limited Ravel Accumulations Following the 2017 Nuns and Tubbs Wildfires in Northern California
Authors: Perkins Jonathan P. , Diaz Carlos , Corbett Skye C. , Cerovski‐Darriau Corina , Stock Jonathan D. , Prancevic Jeff P. , Micheli Elisabeth , Jasperse Jay 
Published: June 2022

AbstractWildfire can impact soil‐hydraulic properties by reducing saturated hydraulic conductivity and sorptivity, making recently burned landscapes prone to debris flows and flash floods. The post‐fire hazard window can range from years to decades. In Northern California, where wildfire frequency is steadily increasing, the impact and soil‐hydraulic recovery from wildfires is unknown. Following the October 2017 Nuns and Tubbs fires in the Northern Bay Area of California, we established 41 monitoring sites for repeat tension‐disc infiltrometer measurements of field‐saturated hydraulic conductivity (Kfs) over 3.5 years. Our site arrays, which encompass grasslands, chaparral, and oak and conifer forests across a range in lithology, show a marked decrease in Kfs following the wildfires and a swift partial recovery following the initial post‐fire rainy season. Our time series reveals a complex path to soil‐hydraulic recovery marked by distinct seasonal stages. Analysis of changing Kfs, sorptivity, and infiltration model residuals collectively suggests that these stages are related to transitions between soil‐hydraulic processes like structural soil sealing from rainsplash, thermal cracking of bare soil, and vegetation regrowth. While soil infiltration rates were strongly impacted by the 2017 fires, dry ravel estimates are an order of magnitude less for similar slopes than the 2009 Station fire in the San Gabriel mountains of Southern California, suggesting that limited ravel flux may insufficiently load channels for debris flows that initiate from within‐channel failure. Our analysis suggests that burned landscapes in the Northern Bay Area of California may experience rapid soil‐hydraulic recovery and limited pathways toward post‐fire debris flow initiation.
Targeting protein phosphatases for the treatment of inflammation-related diseases: From signaling to therapy
Authors: Pan Jie , Zhou Lisha , Zhang Chenyang , Xu Qiang , Sun Yang 
Published: June 2022

AbstractInflammation is the common pathological basis of autoimmune diseases, metabolic diseases, malignant tumors, and other major chronic diseases. Inflammation plays an important role in tissue homeostasis. On one hand, inflammation can sense changes in the tissue environment, induce imbalance of tissue homeostasis, and cause tissue damage. On the other hand, inflammation can also initiate tissue damage repair and maintain normal tissue function by resolving injury and restoring homeostasis. These opposing functions emphasize the significance of accurate regulation of inflammatory homeostasis to ameliorate inflammation-related diseases. Potential mechanisms involve protein phosphorylation modifications by kinases and phosphatases, which have a crucial role in inflammatory homeostasis. The mechanisms by which many kinases resolve inflammation have been well reviewed, whereas a systematic summary of the functions of protein phosphatases in regulating inflammatory homeostasis is lacking. The molecular knowledge of protein phosphatases, and especially the unique biochemical traits of each family member, will be of critical importance for developing drugs that target phosphatases. Here, we provide a comprehensive summary of the structure, the “double-edged sword” function, and the extensive signaling pathways of all protein phosphatases in inflammation-related diseases, as well as their potential inhibitors or activators that can be used in therapeutic interventions in preclinical or clinical trials. We provide an integrated perspective on the current understanding of all the protein phosphatases associated with inflammation-related diseases, with the aim of facilitating the development of drugs that target protein phosphatases for the treatment of inflammation-related diseases.
OPTN attenuates the neurotoxicity of abnormal Tau protein by restoring autophagy
Authors: Xu Yin , Liu Yun , Chen Xi , Xu Qia , Liu Liwei , Liu Hui , Guo Ruowen , Qin Yide 
Published: June 2022

AbstractOPTN is an autophagy receptor involved in autophagic degradation. Here we studied the role of OPTN in attenuating the neurotoxicity induced by mutated Tau protein. We constructed recombinant adeno-associated viruses with OPTN and Tau-P301L genes, respectively. Through virus coinfection on neuronal cell line HT22 in vitro and Kunming mice in vivo, we found that autophagy- and apoptosis-associated genes are altered by Tau-P301L at both mRNA and protein levels, which are restored by OPTN expression. Functionally, OPTN suppresses apoptosis and enhances cellular viability in Tau-P301L expressing HT22 cells, and increases learning and memory in Tau-P301L expressing mice, respectively. Last, we found that OPTN reduces the p-Tau levels in vitro and in vivo. Our results reveal the function of OPTN in lowering the p-Tau level and the expressions of apoptosis genes, and increasing the expressions of autophagic genes, indicating a beneficial role of OPTN in Tau pathology.
Nuclear p120 catenin is a component of the perichromosomal layer and coordinates sister chromatid segregation during mitosis in lung cancer cells
Authors: Chow Shu-Er , Meir Yaa-Jyuhn J. , Li Jhy-Ming , Hsu Ping-Chih , Yang Cheng-Ta 
Published: June 2022

AbstractAbnormal expression of p120 catenin is associated with the malignant phenotype in human lung cancer. Numerous studies have focused on the function of p120 catenin in the juxta-membrane compartment. However, the role of nuclear p120 catenin remains unclear. In this study, the dynamic changes in nuclear p120 catenin localization during cell cycle progression were investigated. Immunofluorescent staining, FACS analysis, and western blotting revealed that nuclear p120 catenin is a major architectural constituent of the chromosome periphery during mitosis. During mitosis, granule-like p120 catenin dispersed into a cloudy-like structure and formed cordon-like structures surrounding the condensed chromosomes to create the peri-chromosomal layer. Interestingly, lumican and p120 catenin colocalized at the spindle fiber where the perichromosomal layer connects to the condensed chromosomes during mitosis. Furthermore, downregulation of p120 catenin using a specific siRNA induced cell cycle stalling in the G2/M phase and promoted aneuploidy. This study validates the role of nuclear p120 catenin in the formation of the chromosome periphery and reveals the p120 catenin-lumican interaction may couple orientation of cell division with the segregation of sister chromatids during mitosis. Our data suggest the protective role of p120 catenin in maintaining the integrity of chromosomes, and also warrants further studies to evaluate the contribution of the loss of p120 catenin to the creation of gene rearrangement in cancer evolution and tumor progression.
Systematic analyses identify the anti-fibrotic role of lncRNA TP53TG1 in IPF
Authors: Sun Jian , Guo Yingying , Chen Tingting , Jin Tongzhu , Ma Lu , Ai Liqiang , Guo Jiayu , Niu Zhihui , Yang Ruoxuan , Wang Qianqian , Yu Xiaojiang , Gao Huiying , Zhang Yuhan , Su Wei , Song Xiaoying , Ji Weihang , Zhang Qing , Huang Mengqin , Fan Xingxing , Du Zhimin , Liang Haihai 
Published: June 2022

AbstractLong non-coding RNA (lncRNA) was reported to be a critical regulator of cellular homeostasis, but poorly understood in idiopathic pulmonary fibrosis (IPF). Here, we systematically identified a crucial lncRNA, p53-induced long non-coding RNA TP53 target 1 (TP53TG1), which was the dysregulated hub gene in IPF regulatory network and one of the top degree genes and down-regulated in IPF-drived fibroblasts. Functional experiments revealed that overexpression of TP53TG1 attenuated the increased expression of fibronectin 1 (Fn1), Collagen 1α1, Collagen 3α1, ACTA2 mRNA, Fn1, and Collagen I protein level, excessive fibroblasts proliferation, migration and differentiation induced by TGF-β1 in MRC-5 as well as PMLFs. In vivo assays identified that forced expression of TP53TG1 by adeno-associated virus 5 (AAV5) not only prevented BLM-induced experimental fibrosis but also reversed established lung fibrosis in the murine model. Mechanistically, TP53TG1 was found to bind to amount of tight junction proteins. Importantly, we found that TP53TG1 binds to the Myosin Heavy Chain 9 (MYH9) to inhibit its protein expression and thus the MYH9-mediated activation of fibroblasts. Collectively, we identified the TP53TG1 as a master suppressor of fibroblast activation and IPF, which could be a potential hub for targeting treatment of the disease.
Dynamics of microbial communities on the corrosion behavior of steel in freshwater environment
Authors: Wakai Satoshi , Eno Nanami , Miyanaga Kazuhiko , Mizukami Hirotaka , Sunaba Toshiyuki , Miyano Yasuyuki 
Published: June 2022

AbstractIn a freshwater environment, accelerated corrosion of carbon and stainless steels is frequently observed. Here, an immersion study was conducted using nine types of steels in a freshwater pool for 22 mo. Accelerated corrosion was observed in carbon and Cr-containing steels and cast iron, whereas no visible corrosion was observed in stainless steels, even after 22 mo. Microbial community analysis showed that, in general corrosion, Fe(II)-oxidizing bacteria were enriched in the early corrosion phase, Fe(III)-reducing bacteria increased in the corrosion-developing phase, and sulfate-reducing bacteria were enriched in the corrosion products during the final corrosion phase. In contrast, in the 9% Cr steel with localized corrosion, the family Beggiatocaea bacteria were particularly enriched. These microbial community compositions also differed from those in the water and sediment samples. Therefore, microbial communities are drastically altered with the progression of corrosion, and iron-dependent microbial energy metabolism contributes to an environment that enables the enrichment of other microorganisms.
Convergent and divergent gray matter volume abnormalities in unaffected first-degree relatives and ultra-high risk individuals of schizophrenia
Authors: Lin Bei , Li Xian-Bin , Ruan Sen , Wu Yu-Xin , Zhang Chao-Yue , Wang Chuan-Yue , Wang Lu-Bin 
Published: June 2022

AbstractHigh-risk populations of schizophrenia can be mainly identified as genetic high-risk based on putative endophenotypes or ultra-high-risk (UHR) based on clinically manifested symptoms. Previous studies have consistently shown brain structural abnormalities in both genetic high-risk and UHR individuals. In this study, we aimed to disentangle the convergent and divergent pattern of gray matter alterations between UHR and unaffected first-degree relatives from genetic high-risk individuals. We used structural MRI scans and voxel-based morphometry method to examine gray matter volume (GMV) differences among 23 UHR subjects meeting the Structured Interview for Prodromal Syndromes (SIPS) criteria, 18 unaffected first-degree relatives (UFDR), 26 first-episode schizophrenia patients (FES) and 54 healthy controls (CN). We found that a number of brain regions exhibited a monotonically decreasing trend of GMV from CN to UFDR to UHR to FES. Compared with CN, the UHR subjects showed significant decreases of GMV similar to the patients in the inferior temporal gyrus, fusiform gyrus, middle occipital gyrus, insula, and limbic regions. Moreover, the UHR transformed subgroup had significantly lower GMV than UHR non-transformed subgroup in the right inferior temporal/fusiform gyrus. On the other hand, the UFDR subjects only showed significant GMV decreases in the inferior temporal gyrus and fusiform. Moreover, we found GMV in the occipital lobe was negatively correlated with the UHR subjects’ composite positive symptom of SIPS, and GMV in the cerebellum was positively correlated with FES subjects’ symptom severity. Our results suggest that GMV deficits and regional dysfunction are evident prior to the onset of psychosis and are more prominent in the UHR than the UFDR individuals.
Macrophage depletion alters bacterial gut microbiota partly through fungal overgrowth in feces that worsens cecal ligation and puncture sepsis mice
Authors: Hiengrach Pratsanee , Panpetch Wimonrat , Chindamporn Ariya , Leelahavanichkul Asada 
Published: June 2022

AbstractBecause macrophage dysfunction from some emerging therapies might worsen gut-derived sepsis, cecal ligation and puncture (CLP) sepsis are performed in mice with clodronate-induced macrophage depletion. Macrophage depletion (non-sepsis) increased fecal Ascormycota, with a subtle change in bacterial microbiota, that possibly induced gut-barrier defect as Candida pintolopesii and Enterococcus faecalis were identified from blood. Sepsis in macrophage-depleted mice was more severe than sepsis control as indicated by mortality, cytokines, organ injury (liver, kidney, and spleen), gut-leakage (FITC-dextran), fecal Proteobacteria, and blood organisms (bacteria and fungi). Lysate of C. pintolopesii or purified (1 → 3)-β-d-glucan (BG; a major component of fungal cell wall) enhanced growth of Klebsiella pneumoniae and Escherichia coli that were isolated from the blood of macrophage-depleted CLP mice implying a direct enhancer to some bacterial species. Moreover, the synergy of LPS and BG on enterocytes (Caco-2) (Transepithelial electrical resistance) and neutrophils (cytokines) also supported an influence of gut fungi in worsening sepsis. In conclusion, macrophage depletion enhanced sepsis through the selectively facilitated growth of some bacteria (dysbiosis) from increased fecal fungi that worsened gut-leakage leading to the profound systemic responses against gut-translocated LPS and BG. Our data indicated a possible adverse effect of macrophage-depleted therapies on enhanced sepsis severity through spontaneous elevation of fecal fungi.
Physiological and biochemical responses of Tanacetum balsamita L. to the foliar application of Dobogen biostimulant, glucose and KNO3 under salinity stress
Authors: Hassanpouraghdam Mohammad Bagher , Vojodi Mehrabani Lamia , Kheiri Mehdi , Chrysargyris Antonios , Tzortzakis Nikolaos 
Published: June 2022

AbstractSalinity is one of the predominant abiotic stress factors that influence the growth and productivity of plants. Salinity adversely impacts the growth responses via ionic toxicity, osmotic stress, impaired nutrients uptake, hormonal disparity, and the over-production of reactive oxygen species. To study the effects of salinity stress (0, 50, 100, and 150 mM) and foliar treatments (dH2O, 2 g L−1 Dobogen biostimulant, 2 g L−1 KNO3, and 2 g L−1d-glucose) on the growth and physiological responses of Tanacetum balsamita, a factorial experiment was conducted based on the completely randomized design at the research greenhouse of Azarbaijan Shahid Madani University, Iran. The results showed the significant interaction effects of salinity and foliar sprays on chlorophyll a, K+, Na+, Mg2+, Fe2+, Zn2+, Mn2+, and Si content, K/Na ratio, and total phenolics and flavonoids content. The highest phenolic content was acquired with 100 mM salinity and foliar spray of Dobogen and glucose, 50 mM NaCl × KNO3 application, and 50 mM salinity × no-foliar application. The highest K/Na ratio was observed in control plants and controls × KNO3 and/or Dobogen application. The greatest Si content was recorded with no-salinity × Dobogen and KNO3 applications and no-saline × no-foliar (control) plants. The independent effects of treatments influenced malondialdehyde, flavonoids, proline contents, and catalase activity. Chlorophyll b and superoxide dismutase were affected by the salinity. Total soluble solids and Ca2+ content were responsive to the foliar applications. Malondialdehyde and proline content was the highest at 150 mM salinity. Salinity adversely affected the physiological responses of costmary. However, foliar treatments partially ameliorated the salinity effect, and the results with more detailed studies would be advisable to the extension section and pioneer farmers.
Effect of Nosema ceranae infection and season on the gut bacteriome composition of the European honeybee (Apis mellifera)
Authors: Jabal-Uriel Clara , Alba Claudio , Higes Mariano , Rodríguez Juan Miguel , Martín-Hernández Raquel 
Published: June 2022

AbstractNosema ceranae is an intracellular parasite that infects honeybees’ gut altering the digestive functions; therefore, it has the potential of affecting the composition of the gut microbiome. In this work, individual bees of known age were sampled both in spring and autumn, and their digestive tracts were assessed for N. ceranae infection. Intestinal microbiome was assessed by sequencing the bacterial 16S rRNA gene in two different gut sections, the anterior section (AS; midgut and a half of ileum) and the posterior section (PS; second half of ileum and rectum). A preliminary analysis with a first batch of samples (n = 42) showed that AS samples had a higher potential to discriminate between infected and non-infected bees than PS samples. As a consequence, AS samples were selected for subsequent analyses. When analyzing the whole set of AS samples (n = 158) no changes in α- or β-diversity were observed between infected and non-infected bees. However, significant changes in the relative abundance of Proteobacteria and Firmicutes appeared when a subgroup of highly infected bees was compared to the group of non-infected bees. Seasonality and bees’ age had a significant impact in shaping the bacteriome structure and composition of the bees’ gut. Further research is needed to elucidate possible associations between the microbiome and N. ceranae infection in order to find efficient strategies for prevention of infections through modulation of bees’ microbiome.
High-resolution deposition of conductive and insulating materials at micrometer scale on complex substrates
Authors: Łysień Mateusz , Witczak Łukasz , Wiatrowska Aneta , Fiączyk Karolina , Gadzalińska Jolanta , Schneider Ludovic , Stręk Wiesław , Karpiński Marcin , Kosior Łukasz , Granek Filip , Kowalczewski Piotr 
Published: June 2022

AbstractAdditive manufacturing transforms the landscape of modern microelectronics. Recent years have witnessed significant progress in the fabrication of 2D planar structures and free-standing 3D architectures. In this work, we present a much-needed intermediary approach: we introduce the Ultra-Precise Deposition (UPD) technology, a versatile platform for material deposition at micrometer scale on complex substrates. The versality of this approach is related to three aspects: material to be deposited (conductive or insulating), shape of the printed structures (lines, dots, arbitrary shapes), as well as type and shape of the substrate (rigid, flexible, hydrophilic, hydrophobic, substrates with pre-existing features). The process is based on the direct, maskless deposition of high-viscosity materials using narrow printing nozzles with the internal diameter in the range from 0.5 to 10 µm. For conductive structures we developed highly concentrated non-Newtonian pastes based on silver, copper, or gold nanoparticles. In this case, the feature size of the printed structures is in the range from 1 to 10 µm and their electrical conductivity is up to 40% of the bulk value, which is the record conductivity for metallic structures printed with spatial resolution below 10 µm. This result is the effect of the synergy between the printing process itself, formulation of the paste, and the proper sintering of the printed structures. We demonstrate a pathway to print such fine structures on complex substrates. We argue that this versatile and stable process paves the way for a widespread use of additive manufacturing for microfabrication.
Solar radio emission as a disturbance of radiomobile networks
Authors: Muratore Giuliano , Giannini Teresa , Micheli Davide 
Published: June 2022

AbstractThis paper analyses the effects of solar radio emissions in the radiomobile context, for the first time leveraging massive European Telecommunications Standards Institute (ETSI) 3rd Generation Partnership Program (3GPP) Minimization of Drive Test (MDT) radio measures produced by 4G LTE (Long Term Evolution) terminals and by 4G LTE Base Station cells. A method to study solar noise effects starting from radiomobile 3GPP standard MDT measures is illustrated and correlated with the excellent 10.7 cm (2800 MHz) indicator of solar activity (National Research Council Canada). The effects of solar disturbance on the LTE radio access network for mobile services are analysed, and possible countermeasures are presented from the perspective of radiomobile network evolution to 5G and 6G.
COVID-19 waves: variant dynamics and control
Authors: Dutta Abhishek 
Published: June 2022

AbstractThe waves of COVID-19 infections driven by its variants continue to nullify the success we achieved through efficacious vaccines, social restrictions, testing and quarantine policies. This paper models the two major variants-driven waves by two sets of susceptible-infected-quarantined-recovered-vaccinated-deceased coupled dynamics that are modulated by the three main interventions: vaccination, quarantine and restrictions. This $$SI^2Q^2R^2VD$$

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system is used to demonstrate that the second major novel coronavirus wave in the US is caused by the delta variant and the corresponding rapid surge in infectious cases is driven by the unvaccinated pool of the populace. Next, a feedback control based planned vaccination strategy is derived and is shown to be able to suppress the surge in infections effectively.