bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance Assessment of Storm Water Drainage System by Stormwater Management Model
Authors: Emama Walabuma Oli , Edae Haile Dida , Fayisa Tolera Abdisa , Hirko Deme Betele 
Published: June 2022

Abstract
As urban population numbers increase, it is evident that urbanization areas continue to expand. This expansion of urban areas mainly changes the natural land surface to the artificial landscape. The urban landscape is partly impervious, and it will decrease infiltration and in reverse increase the volume of surface runoff which causes several destructions in the town. Thus, the study was to assess the performance of the stormwater drainage system of Ambo town. The data have been used for this study were both spatial and temporal data. Rainfall data for 1987 to 2018 years and digital elevation models, land use, and soil data were used. Additionally, canal dimensions and sub-catchment data were also used. For this study, SWMM for simulating rainfall-runoff, the water level in the junctions, and flow depth in the canal were used. ARC-GIS was used to obtain spatial information and delineate the catchment of the study area. Intensity duration frequency curves of Ambo were developed using Gumbel distribution methods to analyze peak runoff for different return periods. The total runoff from the whole catchment using the rational method is 60.32m 3 /s, whereas the stormwater management model (SWMM) is 60.87m 3 /s. The model performance was evaluated using performance measuring techniques including Nash Sutcliff Efficiency (NSE) and Coefficient of Determination (R2), and the values were RNS = 0.997 and R2 = 0.997 respectively for a ten-year return period which shows the model gives good results. From simulation results, 22% of junctions are insufficient to accommodate maximum flooding, and 21% of canals are surcharged. So, from the simulation results, most of the junction and canal dimensions are insufficient to drain the generated runoff from the sub-catchments. To alleviate these problems, clearing, on-time maintenance, redesign, and constructing the adequate canal are recommended for Ambo town.
Fluoride and Nitrate in groundwater: A comprehensive analysis of health risk and potability of groundwater of Jhunjhunu district of Rajasthan, India
Authors: Tanwer Naresh , Deswal Meena , Khyalia Pradeep , Laura Jitender Singh , Khosla Babita 
Published: June 2022

Abstract
Groundwater contamination is a major concern in front of the scientific community because it is directly related to human health, especially in arid and semi-arid regions. Therefore, a comprehensive study was engaged to evaluate the water quality, potability, and human health risk assessment due to the consumption of fluoride and nitrate-contaminated water in Jhunjhunu district of Rajasthan. In water quality, 16 parameters were analyzed as per the standard method of APHA(American Public health Association ), 2017, collected from 87 locations in the study region, and results found that the value of the number of quality parameters consisting of pH, EC, TDS, fluoride, chloride, nitrate, sulphate, total hardness, calcium, magnesium, and total alkalinity was observed higher than the recommended limit of BIS (Bureau of Indian standard), 2012 and WHO (World Health Organization), 2017. The fluoride in 11% and nitrate in 6% samples were observed to exceed the permissible limit of WHO. The results of risk assessment due to fluoride and nitrate revealed that Hazard Index values of 71% groundwater samples for males, 78% groundwater samples for females, and 75% groundwater samples for children were greater than 1, indicating the significant health hazard due to consumption of groundwater. The water quality index (WQI) found that 37% of groundwater samples belong to categories that cannot be used for drinking purposes. Principal component analysis (PCA) reduced the large number of variables affecting the overall quality and chemistry of groundwater and determined four major components which account for 69.50% variance in the data.
Nonlinear-Fourier-transform-based dynamic analyses on the multiple cavity solitons in Kerr microresonators
Authors: Pan Jianxing , Huang Tianye , Wu Zhichao , Wang Yutain , Xu Chaoyu , Zhang Jing , Zhao Luming 
Published: June 2022

Abstract
The Kerr microresonators have aroused widespread interests for their ultrahigh integration, compatible fabrication and ultralow energy consumption. Similar to the traditional mode-locked fiber lasers, the microresontors can sustain the generation of dissipative solitons called cavity solitons relying on the double balance of gain and loss as well as nonlinearity and dispersion. The state of multiple solitons is common in the microresonator with anomalous dispersion. In particular, an ideal state named as soliton crystals is obtained when the multiple solitons have a equidistant arrangement. And recent experiments have successfullly observed soliton crystals in the Kerr microresonators. To intuitively reveal the formation and evolution dynamics of the multiple solitons and get insight into the underlying physical mechanisms of soliton crystals, we applied the nonlinear Fourier transform to project these states into nonlinear discrete spectrum. The discrete spectra of single soliton with different modulated background waves have been displayed, which can help distinguish different optical components. Then, the nonlinear spectrum evolution of normal multiple solitons state shows the typical nonlinear states of the intracavity field. And the equidistant solitons have the effects of power enhancement, whose spectral intensity is several times that of a single soliton state. Comparing with the discrete spectrum of the equidistant solitons, the solitons inside the soliton crystals interact with each other by the modulated background. Our results suggest that the nonlinear Fourier transform is a powerful technique to characterize soliton dynamics in the Kerr microresonator, which provides a new perspective to understand the interactions of cavity solitons.
TREX1 p.A129fs and p.Y305C variants in a large multi-ethnic cohort of CADASIL-like unrelated patients
Authors: Foddis Marco , Blumenau Sonja , Holtgrewe Manuel , Paquette Kimberly , Westra Kaitlyn , Alonso Isabel , Macario Maria Carmo , Morgadinho Ana Sofia , Velon Ana Graça , Santo Gustavo , Santana Isabel , Mönkäre Saana , Kuuluvainen Liina , Schleutker Johanna , Pöyhönen Minna , Myllykangas Liisa , Pavlovic Aleksandra , Kostic Vladimir , Dobricic Valerija , Lohmann Ebba , Hanagasi Hasmet , Santos Mariana , Guven Gamze , Bilgic Basar , Bras Jose , Beule Dieter , Dirnagl Ulrich , Guerreiro Rita , Sassi Celeste 
Published: June 2022

Abstract
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and retinal vasculopathy and cerebral leukodystrophy (RVCL) are very rare monogenic disorders and the most common forms of early-onset cerebral small vessel disease. These diseases share clinical and, to a different extent, neuroradiological and neuropathological features. Recently, a growing body of evidence reported significant contribution of TREX1 mutations in CADASIL and CADASIL-like patients. However, whether CADASIL and RVCL overlapping phenotype may be explained by shared genetic causative factors remains poorly understood. To investigate this intriguing hypothesis, we performed exome sequencing in a large multi-ethnic cohort of 180 early-onset independent familial and apparently sporadic CADASIL-like Caucasian patients from the USA, Portugal, Finland, Serbia and Turkey. None of the cases carried NOTCH3 causative mutations clustering in epidermal growth factor like repeat domains, mapping to exons 3 and 4 or consisting in the gain or loss of cysteine. We report 2 very rare and likely pathogenic TREX1 mutations: a loss of function mutation (p.Ala129fs) clustering in the catalytic domain, in an apparently sporadic 46-year-old patient from the USA and a missense mutation (p.Tyr305Cys) in the well conserved C-terminal region, in a 57-year-old patient with positive family history from Serbia. These mutations were not detected in a large cohort of elderly, neuropathologically assessed controls (https://www.alzforum.org/exomes/hex).In concert with recent findings, our study expands the clinical spectrum of diseases associated with TREX1 mutations, the genetic causative factors linked to CADASIL-like phenotypes and warrants further investigations in larger cohorts of stroke patients.
Efficacy and safety of dutasteride with tadalafil add-on therapy in Japanese men with lower urinary tract symptoms secondary to benign prostatic hyperplasia
Authors: Gotoh Daisuke , Torimoto Kazumasa , Morizawa Yosuke , Hori Shunta , Nakai Yasushi , Miyake Makito , Fujimoto Kiyohide 
Published: June 2022

Abstract
Objective: To evaluate the efficacy and safety of add-on therapy with the phosphodiesterase type 5 inhibitor tadalafil in Japanese men with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) treated with dutasteride.Results: The participants had a mean age of 68.9 ± 7.4 years and prostate volume of 37.1 ± 14.2 mL as measured using transabdominal sonography. The efficacy indicators, such as International Prostate Symptom Score, quality of life score, night-time urinary frequency, and night-time maximum voided volume, improved significantly at 4 weeks, and the effects lasted until 24 weeks. Overactive bladder symptom score and sexual health inventory for men significantly improved at 12 weeks, and the effects lasted until 24 weeks. However, maximum urine flow and residual urine volume showed no improvement at any point. Adverse events occurred in two cases. Taken together, add-on therapy with tadalafil was effective for patients with LUTS/BPH resistant to dutasteride monotherapy. In addition, this therapy was not associated with severe adverse events.
Dynamics of stimuli-based fractional-order memristor-coupled tabu learning two-neuron model and its engineering applications
Authors: ding dawei , chen xiaoyu , Yang Zongli , hu yongbing , wang mouyuan , niu yan 
Published: June 2022

Abstract
External stimulus has an impact on the functional behavior of the biological nervous system, and appropriate stimulus helps the organism to maintain neural function. Inspired by this, the effects of different external stimuli on the dynamic behaviors of neuron model are studied in this paper. Firstly, a fractional-order(FO) memristor-coupled tabu learning two-neuron model whose equilibrium points are symmetric about the origin and unstable is constructed. The dynamic behaviors of this neuron model under different stimuli is further discussed, which are no external stimulus, external forced current stimulus and electromagnetic radiation (EMR) respectively. The neuron model without external stimulus has periodic attractors, but applying external stimulus to one of the neurons can produce abundant two-scroll chaotic attractors and multistability. Especially, when the neuron model is stimulated by EMR, it can generate hyperchaotic attractors that have not been observed in the tabu learning neuron model before. Besides, the transient transition behaviors of the model under different stimuli are also studied. Then, a pseudo-random number generator (PRNG) is designed and its random performance is tested with NIST suite. Finally, it is applied to voice encryption, and the result shows that it has good encryption effect. Therefore, it can be said that the FO memristor-coupled tabu learning two-neuron model has superior randomness and is suitable for chaotic-based engineering applications.
Women’s acceptability of a self-collect HPV same-day screen-and-treat program in a high burden setting in the Pacific
Authors: Camara Hawa , Nosi Somu , Munnull Gloria , Badman Steven G. , Bolgna John , Kuk Joseph , Mola Glen , Guy Rebecca , Vallely Andrew J. , Kelly-Hanku Angela M. 
Published: June 2022

Abstract
Background: A field trial to evaluate a self-collect point-of-care HPV screen-and-treat (HPV S&T) program was implemented in two Well Women Clinics in Papua New Guinea (Papua New Guinea). Assessing the acceptability of a health intervention is a core element of evaluation. In this study, we examined women’s acceptability of both self-collection and HPV S&T intervention in Papua New Guinea. Methods: Sixty-two semi-structured interviews were conducted with women who had undergone cervical screening in the same-day self-collected HPV screen-and-treat program in Madang and Western Highlands Provinces, Papua New Guinea. Data were thematically analysed using the Theoretical Framework of Acceptability (TFA) and managed using NVivo 12.5. Results: Self-collection was highly acceptable to women as it meant they could forgo what was deemed a culturally embarrassing cervical examination. The provision of same-day results, and treatment if indicated, was particularly valued by the women because it reduced the financial and temporal burden to return to the clinic for results. It also meant they did not need to wait anxiously for long periods of time for their results. Women also appreciated the support from, and expertise of, health care workers throughout the process and spoke of trust in the HPV-DNA testing technology. The majority of women were willing to pay for the service to ensure its sustainability and timely scale-up throughout Papua New Guinea to support access for women in harder to reach areas. Conclusion: This study reported very high levels of acceptability from a field trial of self-collection and HPV same-day screen-and-treat. The program was deemed culturally congruent and time efficient. As the cervical screening program is taken to scale across Papua New Guinea ensuring ongoing acceptability of the program will be needed. Further research will be required for additional insights into the program’s acceptability in Papua New Guinea and other high-burden settings. This innovative cervical screening modality could be the ‘solution’ needed to see wider and more immediate impact and improved outcomes for women in Papua New Guinea and other high-burden, low-resource settings.
SLC6A14 facilitates epithelial cell ferroptosis via the C/EBPβ-PAK6 axis in ulcerative colitis
Authors: Chen Yanjun , Yan Wenying , Chen Yuqi , Zhu Jinhan , Wang Jiayu , Jin Haiyan , Wu Hongya , Zhang Guangbo , Zhan Shenghua , Xi Qinhua , Shi Tongguo , Chen Weichang 
Published: June 2022

Abstract
Emerging evidence suggests that ferroptosis is involved in the pathogenesis of ulcerative colitis (UC). However, the key regulator of this process remains uncertain. In this study, we aimed to explore the roles of solute carrier (SLC) family 6 member 14 (SLC6A14) in regulating ferroptosis in UC. The expression of SLC6A14 was significantly increased and positively associated with that of prostaglandin-endoperoxide synthase 2 (PTGS2) in tissue samples from patients with UC. Moreover, a series of in vitro and in vivo experiments showed that SLC6A14 knockdown markedly suppressed ferroptosis. RNA sequencing revealed that SLC6A14 inhibited the expression of P21 (RAC1) activated kinase 6 (PAK6) and that PAK6 knockdown abolished the effects of SLC6A14 on RAS-selective lethal 3 (RSL3) -induced ferroptosis in Caco-2 cells. Furthermore, chromatin immunoprecipitation (ChIP) and Western blot analysis demonstrated that SLC6A14 negatively regulated PAK6 expression in a CCAAT enhancer binding protein beta (C/EBPβ)-dependent manner. Collectively, these findings indicate that SLC6A14 facilitates ferroptosis in UC by promoting C/EBPβ expression and binding activity to inhibit PAK6 expression, suggesting that targeting SLC6A14-C/EBPβ-PAK6 axis-mediated ferroptosis may be a promising therapeutic alternative for UC.
Prevalence, Barriers and Facilitators Influencing Modern Contraceptive Use Among Postpartum Mothers at Ober and Barapwo Health Centre III, Lira City: a Cross Sectional Design
Authors: Isoke Robert , Kunihira Irene , Apili Felister 
Published: June 2022

Abstract
Background
Short Births to Pregnancy intervals have been associated with maternal mortality and morbidity as they increase the risk for pregnancy related complications. Modern contraceptive use during postpartum period has proved to be effective in reducing maternal morbidity and mortality through prolonging the birth to pregnancy interval and preventing unplanned and unwanted pregnancies. However little is known about the prevalence of use as well as the factors influencing the use of these modern contraceptives in Lira city, Northern Uganda.
Objective
To find out the prevalence, barriers and facilitators associated with utilization of modern contraceptive methods among postpartum women at Barapwo Health Centre III and Ober Health Centre III, Lira city, Northern Uganda.
Methods
A facility-based cross-sectional study design. Data were collected using an interviewer-administered semi-structured questionnaire. Analysis was done by both bivariable and multivariable logistics regression considering p-vale < 0.005 to be significant and a 95% confidence interval. The prevalence was determined quantitatively by ascertaining number of mother who were using modern contraception at the time of study while the factors influencing postpartum modern contraceptive use were obtained both using structured questions and open ended questions. The study included 391 postpartum women who were randomly selected and were receiving care at Ober and Barapwo Health Centre III.
Results
The prevalence of utilization of modern contraceptives among postpartum women was 49.4%. from multivariable logistics regression, partner acceptance, > 500000 average household income, resumption of menses, 7–12 weeks postpartum, 37–72 weeks postpartum, resumption of sex, ever used contraception, feeling it is okay, health education and counselling on family planning were 13.46, 2.36, 4.42, 2.22, 3.89, 2.82, 2.44, 31.53, 1.78 and 2.38 times respectively more likely to use modern contraception.
Conclusion and recommendation:
The modern contraceptive use among postpartum women attending Ober and Barapwo health center IIIs is high compared to the national contraceptive use. Therefore, interventions to sensitize the population about the use of these methods should be done to address barriers to uptake.
Identifying key players in a network of child exploitation websites using Principal Component Analysis
Authors: Movahedi F. , Frank R. 
Published: June 2022

Abstract
One of the main objectives of this study is to help prioritize targets for law enforcement by analyzing online websites hosting child exploitation material and finding key players within. Key players are defined as the websites which display a combination of high connectivity and a lot of hardcore material and would provide the most disruption in a network if they were to be removed. In this study, various strategies based on Principal Component Analysis are presented to identify those nodes that act as the key players in an online child exploitation network. For evaluating the results of these strategies, we consider the results of various attack strategies. The measures for evaluation are the density, clustering coefficient, average path length, diameter and the number of connected components in the resulted network. The results show that the strategies proposed are more successful at reducing all of the outcome measures than existing strategies.
TRIM22 suppresses zika virus replication by targeting NS1 and NS3 for proteasomal degradation
Authors: Zu Shulong , Li Chunfeng , Li Lili , Deng Yong-Qiang , Chen Xiang , Luo Dan , Ye Qing , Huang Yi-Jiao , Li Xiao-Feng , Zhang Rong-Rong , Sun Nina , Zhang Xianqi , Aliyari Saba R. , Nielsen-Saines Karin , Jung Jae U , Yang Heng , Qin Cheng-Feng , Cheng Genhong 
Published: June 2022

Abstract
Background: Recognition of viral invasion by innate antiviral immune system triggers activation of the Type I-interferon (IFN-I) and proinflammatory signaling pathways. Subsequently, IFN-I induction regulates expression of a group of genes known as IFN-I-stimulated genes (ISGs) to block viral infection. The Tripartite Ring Interaction Motif 22 (TRIM22) is an ISG with strong antiviral functions. Results: Here we have shown that the TRIM22 has been strongly upregulated both transcriptionally and translationally upon zika virus (ZIKV) infection. ZIKV infection is associated with a wide range of clinical manifestations in human from mild to severe symptoms including abnormal fetal brain development. We found that the antiviral function of TRIM22 plays a crucial role in counterattacking ZIKV infection. Overexpression of TRIM22 protein inhibited ZIKV growth whereas deletion of TRIM22 in host cells increased ZIKV infectivity. Mechanistically, TRIM22, as a functional E3 ubiquitin ligase, promoted the ubiquitination and degradation of ZIKV nonstructural protein 1 (NS1) and nonstructural protein 3 (NS3). Further studies showed that the SPRY domain and Ring domain of TRIM22 played important roles in protein interaction and degradation, respectively. In addition, we found that TRIM22 also inhibited other flaviviruses infection including dengue virus (DENV) and yellow fever virus (YFV). Conclusion: Thus, TRIM22 is an ISG with critical role in host defense against flaviviruses through binding and degradation of the NS1 and NS3 proteins.
STEAP2, as an oncogene, enhanced the invasion ability of cervical caner cells and promoted EMT through PI3K/AKT/mTOR pathway
Authors: Wang Mei , Li Na , Yang Chunrun , Wang Fei 
Published: June 2022

Abstract
Despite the established pivotal role of STEAP2 (six-transmembrane epithelial antigen of prostate 2) in the progression of prostate cancer, its prognostic value and functionality in cervical carcinoma have not been comprehensively analyzed. The STEAP2 expressions in healthy and cancerous cervical tissues, as well as in five varying cervical carcinoma cells (Ca Ski, HeLa, SiHa, C33A and HT-3) were checked by immunohistochemistry and western blotting. The association of STEAP2 with the outcome was explored by the Kaplan-Meier method among the cervical carcinoma population. Through the in-vivo and in-vitro lentiviral transfection and cellular functionality assays, we examined how the STEAP2 elevation and decline influenced the biological properties of cervical carcinoma cells. Furthermore, the effects of STEAP2 knockdown or over-expression on the crucial EMT (epithelial–to–mesenchymal transition) hallmarks and matrix metalloproteinases (MMPs) were also determined by real time RT-qPCR in conjunction with western-blot. As demonstrated the results, high STEAP2 level in cancerous cervical tissues was associated positively with the clinico-pathological traits of malignant cervical cancer and the poor prognosis of patients. Through the PI3K/AKT/mTOR axis deactivation, the STEAP2 knockdown could significantly inhibit cellular proliferation and invasion abilities, reduce the MMP-1 plus MMP-13 levels, and impede the EMT event. Meanwhile, STEAP2 over-expression had the opposite effects. All in all, STEAP2, as an oncogene, enhanced the invasion ability of cervical caner cells and promoted EMT through PI3K/AKT/mTOR axis, which thus probably acts as a therapeutic target for suppressing the cervical carcinoma cell invasion.