bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lifetime of actin-dependent protein nanoclusters
Authors: Sarkar Sumantra , Goswami Debanjan 
Published: January 2022

AbstractProtein nanoclusters (PNCs) are dynamic collections of a few proteins that spatially organize in nanometer length clusters. PNCs are one of the principal forms of spatial organization of membrane proteins and they have been shown or hypothesized to be important in various cellular processes, including cell signaling. PNCs show remarkable diversity in size, shape, and lifetime. In particular, the lifetime of PNCs can vary over a wide range of timescales. The diversity in size and shape can be explained by the interaction of the clustering proteins with the actin cytoskeleton or the lipid membrane, but very little is known about the processes that determine the lifetime of the nanoclusters. In this paper, using mathematical modelling of the cluster dynamics, we model the biophysical processes that determine the lifetime of actin-dependent PNCs. In particular, we investigated the role of actin aster fragmentation, which had been suggested to be a key determinant of the PNC lifetime, and found that it is important only for a small class of PNCs. A simple extension of our model allowed us to investigate the kinetics of protein-ligand interaction near PNCs. We found an anomalous increase in the lifetime of ligands near PNCs, which agrees remarkably well with experimental data on RAS-RAF kinetics. In particular, analysis of the RAS-RAF data through our model provides falsifiable predictions and novel hypotheses that will not only shed light on the role of RAS-RAF kinetics in various cancers, but also will be useful in studying membrane protein clustering in general.SignificanceSpatial organization of biomolecules shapes the behavior of a cell. It is particularly important during cell-signaling, where transient, dynamic organization of the biomolecules helps cells process signals and respond to them. Nanoclusters of peripheral membrane proteins, such as KRAS, a specific form of dynamic organization of biomolecules, play a critical part in the modulation of cell signals that control various cellular behaviors including cell growth, proliferation, and differentiation. Although we have made significant progress in understanding the structure, size, and origin of the nanoclusters, very little is known about the biophysical processes that control their lifetime. In this paper, we present a mathematical framework that provides quantitative insights into these processes and explains how oncogenic mutations in KRAS may lead to cancers.
Influence of the perceived benefit of a social network-based sales promotion on the perceived quality of a heritage complex
Authors: Crespo-Almendros Esmeralda , Prados-Peña M. Belén , Porcu Lucia , Alcántara-Pilar Juan Miguel 
Published: January 2022

Purpose This study seeks to analyze the influence of the consumer's perceived benefits deriving from two different promotional incentives offered via social media on the perceived quality of the heritage complex.Design/methodology/approach A quasi-experimental study was carried out among online users, implementing two different promotional stimuli. Facebook was selected as the social network through which the promotional incentives were offered in the experiment. The sample was obtained via a panel of Internet users provided by Sondea Internet SL.Findings The results showed that the benefits perceived by the tourists will depend on the sales promotion type offered. On the one hand, free VIP pass was found to be mostly related to hedonic benefits that positively affect perceived quality. On the other hand, 2 × 1 offer would be perceived as a utilitarian benefit and is likely to exert a fairly negative effect on perceived quality.Practical implications Tourism managers and practitioners are encouraged to analyze the characteristics of certain types of sales promotions, as each promotional incentive bears different values and associated benefits. The findings of this study suggest managers and practitioners to implement non-monetary promotions to enhance brand equity and perceived quality. Thus, it is paramount for the managers of cultural institutions and heritage sites to trust in sales promotions which can be very helpful if they are designed carefully.Originality/value This study pioneers the analysis of the impact of the benefits associated with different typologies of sales promotions on social networks on the perceived quality of a heritage site.
“Ambidexterity”: trump card for farm's innovativeness and competitiveness
Authors: Vecchio Yari , Francescone Martina , Adinolfi Felice , De Rosa Marcello 
Published: January 2022

PurposeThe paper aims to analyze the relevance of networking and social capital in promoting the adoption of sustainable innovation, then reinforcing trajectories of multifunctional agriculture. It puts forwards a systemic perspective by focusing on agricultural knowledge and innovation systems. More precisely, we share the idea of “micro agricultural knowledge and innovation systems”, by addressing ambidexterity as engine for boosting sustainable innovation.Design/methodology/approachEmpirical analysis is focused on sustainable innovation adopted by young farmers in Italy and on the mediation effect of ambidextrous relations in performing innovation adoption. Ambidextrous relations are analyzed within at the micro-AKIS level, through the lens of social capital. Relationships between social capital and innovation adoption are statistically measured.FindingsThe analysis shows how ambidexterity develops a mediation effect, with a strong impact on the farm's innovative capacity. Actually, our results confirm that ambidextrous relations reveal good performance and stimulate innovation and, consequently, farms' competitiveness, alongside the path of multifunctional agriculture. As a consequence, the relevance of networking activity in adoption of sustainable innovation may address possible policy action with the aim to strengthen ambidexterity and farm's innovativeness.Originality/valueThe paper tries to fill a gap in literature, by focusing on micro-AKIS which are explored through the lens of social capital.
Clean and green: the relevance of hotels' website quality and environmental management initiatives for green customer loyalty
Authors: Sun Hongzheng , Samad Sarminah , Rehman Shafique Ur , Usman Muhammad 
Published: January 2022

PurposeCustomers' focus increasingly turns to the green practices of firms. Organizations need to rethink their strategies and position themselves concerning their environmental responsibility. The idea behind this study is to observe the influence of hotel website quality and hotel environmental management initiative (HEMI) on green customer loyalty in the Pakistan hotel industry with the mediating role of green trust (GT) and green satisfaction (GS).Design/methodology/approachThe study is quantitative, and partial least squares structural equation modelling followed to test the proposed hypotheses. A total of 542 questionnaires were used for analysis through SPSS 25.0 and SmartPLS 3.2.9.FindingsThe findings confirm the proposed positive influence of hotel website quality and HEMI on green customer loyalty. Moreover, GT and GS significantly mediate the relationship, further enhancing the relevance of green practices for hotels.Practical implicationsHotel management can get maximum customer loyalty to concentrate on hotel website quality, HEMI, GT and GS.Originality/valueThis study aims to develop a research model to incorporate hotel website quality, HEMI, GT, GS and green customer loyalty by using signalling theory and natural resource-based view theory that prior studies ignored.
Social interactions and mutual fund portfolios: the role of alumni networks in China
Authors: Liang Quanxi , Liao Jiangshan , Ling Leng 
Published: January 2022

PurposeThis paper aims to investigate the influence of social interactions on mutual fund portfolios from the perspective of alumni network in China.Design/methodology/approachBased on a data set that consists of 162 actively managed equity funds in China during the time period of 2003–2014, this study employs multiple linear regression model to control for organization- and location-based interpersonal connections as well as other confounding factors and clarify the causality relationship between alumni networks of mutual fund managers and their portfolios.FindingsAfter controlling for organization- and location-based interpersonal connections, we find that mutual fund managers who graduated from the same college/university have more similar stock holdings and are more likely to buy or sell the same stocks contemporaneously. As a result, alumni managers exhibit a higher correlation of fund returns. Moreover, the effect of alumni relationship on mutual fund investments becomes weaker when more managers are connected within the network. We also find that valuable information is shared among alumni managers: (1) the average returns for the alumni common holdings portfolios is significantly higher than those for non-alumni holdings portfolios and (2) a long-short strategy composed of stocks purchased minus sold by alumni managers yields positive and significant risk-adjusted returns.Practical implicationsThe findings suggest that information dissemination among connected fund managers could be one of the driving forces for mutual fund herding behavior, and that a portfolio of funds whose managers are educationally connected could be highly exposed to certain stocks and risks.Originality/valueThis paper contributes to the growing finance literature addressing the influence of personal connections on information dissemination that specifically contributes to price formation. It corresponds more closely to Cohen et al. (2008), who investigate college alumni connections between fund managers and corporate board members. Since the authors simultaneously examine three potentially overlapped social networks, which are based on education, locality and fund family, the authors are able to disentangle their effects on fund managers' investment decisions. Moreover, the findings suggest that institutional investors make investment decisions based on share private information, and therefore, it also contributes to the literature on fund herding behaviors (Grinblatt et al., 1995; Wermers, 1999).
Ecological restoration through natural regeneration in Chunati Wildlife Sanctuary – a protected area of South-East Bangladesh
Authors: Mamun Abdullah Al , Hossain Mohammed Kamal , Hossain Md. Akhter 
Published: January 2022

PurposeIn this paper, the authors show that ecological restoration potential through natural regeneration of degraded tropical rainforest is possible. This is significant because at present most of the tropical forest of the world, including of Bangladesh, are degraded.Design/methodology/approachRegeneration status of Chunati Wildlife Sanctuary (CWS) was assessed through stratified random sampling method using sample plots of 5 × 5 m in size covering 269 sample plots.FindingsA total of 3,256 regenerating seedlings/saplings of 105 species belonging to 35 families were recorded from CWS. From regenerating tree species, maximum (37.83) family importance value (FIV) index was found for Euphorbiaceae followed by Myrtaceae (18.03). Maximum importance value index (IVI) was found for Aporosa wallichii (21.62) followed by Grewia nervosa (16.41). Distribution of seedlings into different height classes of regenerating tree species was also calculated.Practical implicationsForest scientists are working to find out the best nature-based solution for ecological restoration of tropical rainforests to attain climate resilient ecosystem in a sustainable way. Tropical rain forest has huge plant diversity, and we find that ecological restoration is possible through natural regeneration from its rich soil seed bank. Natural regeneration is the best nature-based solution for sustainable management of the forest.Social implicationsThe authors believe that the findings presented in our paper will appeal to the forest and environmental scientists. The findings will allow readers to understand degraded tropical hill forest ecosystem and its management strategy.Originality/value The authors believe that this manuscript will give a clear picture about degraded tropical hill forest ecosystem and its genetic composition, diversity and soil seed bank status to apply appropriate management strategy.
A disruptive model for delivering higher education programs within the context of entrepreneurship education
Authors: de Waal Gerrit Anton , Maritz Alex 
Published: January 2022

PurposeThe purpose of this practitioner paper is to explore whether the principles of Design Thinking and the Lean Startup could be employed in developing a disruptive model for delivering educational programs within higher education in a way that attempts to eliminate the multitude of problems facing this industry, while simultaneously adhering to the principles of frugal innovation and meeting relevant sustainability goals.Design/methodology/approachThe authors followed a design thinking approach, employing tools such as empathy mapping, customer journey, value proposition and semi-structured interviews to obtain a deep level of understanding of the problems educators and students within the context of entrepreneurship education are facing. Throughout the process they drew on the practice of emergent inquiry and customer co-creation to help guide decision making.FindingsThe authors successfully derived a conceptual solution in the form of a Minimum Viable Product of which the features were tested against the multitude of user needs and requirements. It was possible to demonstrate how the solution meets all nine of the requirements for frugal innovations while simultaneously adhering to applicable sustainability principles.Practical implicationsThe proposed solution offers a potential opportunity to first-movers in chosen academic disciplines to become leaders in online education.Originality/valueEven in an industry such as higher education there is a dire need for frugality and finding sustainable solutions for educators and students in both developed and developing markets. With this paper the authors succeed in presenting innovative combinations of digital artefacts, platforms and infrastructure to arrive at a novel crowd-sourced solution that is unique in its design.
Sustainable cities through household waste management: an unexplored approach to challenges confronting private solid waste management
Authors: Ebekozien Andrew , Aigbavboa Clinton , Nwaole Angeline Ngozika Chibuike , Aginah Ibeabuchi Lawrence , Aigbedion Marvelous 
Published: January 2022

Purpose
In less than a decade to sustainable development goals (SDGs) there is a threat of household waste emanating from sub-urban sprawl especially in developing countries. Private approaches with government-enabling environments have been proved a successful platform for urban services such as housing provision and telecommunication in developing cities. Still private solid waste management (PSWM) seems different in Nigeria. Therefore, this paper aims to investigate the possible perceived hindrances facing PSWM organisations and proffer feasible policies to enhance sustainable clean and healthy cities.

Design/methodology/approach
Seven communities within Benin City sub-urban environs were adopted as the study area to accomplish the research’s objectives via a phenomenology type of qualitative research design. The study analysed the collated data from the knowledgeable participants via a thematic approach.

Findings
Lax legislative, absence of institutional framework, inadequate economic motivation, inadequate technical operations, among others, emerged as the encumbrances faced by PSWM firms. Wastes dumped along unethical locations such as streets, roads, uncompleted buildings, culverts and drainage channels, and undeveloped plots emerged as the encumbrance outcomes. Findings show that proffering feasible policy solutions to tackle identified hindrances can promote the achievement of SDGs across semi-urban locations in Nigeria.

Research limitations/implications
This research is restricted to urban household waste management by PSWM within Nigeria. Also, the study identified the challenges and proffer policy solutions to enhance improved clean environment within the sub-urban and urban cities.

Practical implications
As part of this study’s implications, results from this research intend to guide government policymakers and PSWM firms to encourage collaboration in designing appropriate strategic and educational programmes for the householders (customers) in sub-cities. It will be achieved via feasible policies that are tailored towards achieving sustainable health and environment-friendly sub-urban locations.

Originality/value
This paper intends to enhance proper PSWM and create sustainable cities via collaboration. Also, the paper engaged key stakeholders via a qualitative research design to proffer possible solutions to the menace of sub-urban and urban household waste management.
Mortgage delinquency during COVID-19: do financial literacy and personality traits matter?
Authors: Chhatwani Malvika 
Published: January 2022

PurposeMortgage delinquency has become a major crisis following the COVID-19 pandemic. This study explored mortgage delinquency antecedents, focusing on two individual-level factors: financial literacy and personality traits.Design/methodology/approachUsing a large sample of 2,511 consumers, we examined the direct effect of financial literacy and its interaction with personality traits to predict mortgage delinquency based on logistic regression analysis. We further provide several robustness tests to validate our findings.FindingsWe find that financially literate consumers are 6% less likely to delay their mortgage repayment during the COVID-19 pandemic. Moreover, personality traits such as neuroticism and extroversion positively and conscientiousness negatively moderate the given linkage between financial literacy and mortgage delinquency.Practical implicationsBanks and financial companies may devise relevant policies to reduce mortgage repayment by knowing the interplay between financial literacy and personality traits. Personality traits can be considered one of the parameters while sanctioning mortgages to prospective customers.Originality/valueOur research examines the linkage between financial literacy, personality traits and mortgage delinquency based on a large nationally representative sample. Our findings suggest that personality traits moderate the effect of financial literacy on mortgage delinquency.
Purchase intention of Indian customers: a study on solar PV technology
Authors: Atulkar Sunil 
Published: January 2022

Purpose
With the growing acceptance of renewable energy sources in the world, new energy sources are pursued and investigated by customers. In India, residential PV technology is in an early stage of development and very less in demand among households. Therefore, the purpose of this study is to identify the major variables and its impact on customers purchase intention towards solar PV technology, especially in the context of central India.

Design/methodology/approach
Based on literature reviews, this study identifies six major independent variables having a relationship with purchase intentions. Using convenience sampling method, 413 customers’ data has been collected by the researcher and was investigated through structural equation modelling, using SmartPLS 2.0 and SPSS-20 software.

Findings
The study findings suggested that the construct promotional strategies, societal influence, customer awareness and government initiative plays an important role in generating customers purchase intention towards solar PV technology. While the constructs environmental concern and availability & cost having relationship, showed insignificant influence.

Research limitations/implications
The study outcomes provide some valuable insights to the government and policymakers in designing their policies and strategies to increase customer involvement in solar PV technology. This study suggested that the service providers need to offer more benefits in the form of subsidies and schemes that motivate customers to willingly show their purchase intention.

Originality/value
The major contribution of this study is the empirical analysis of six independent variables, which affects the customer purchase intentions towards solar PV technology over available conventional energy sources in an emerging Indian market.
Modelling inter-firm competitive rivalry in a port logistics cluster: a case study of Melbourne, Australia
Authors: Singh Amanpreet , Chhetri Prem , Padhye Rajiv 
Published: January 2022

PurposeThe paper models the effect of spatial clustering on various dimensions of inter-firm competitive rivalry among port logistics firms using Porter's five forces model.Design/methodology/approachA survey-based quantitative approach is adopted to collect data from logistics firms, which are directly or indirectly dependent on the Port of Melbourne in Australia. A structural equation modelling (SEM) technique is used to examine the theorised relationships between various dimensions of inter-firm competitive rivalry and the tendency of spatial clustering of logistics firms in the vicinity of Port of Melbourne.FindingsThe results indicate that the inter-firm competitive rivalry increases significantly when logistics firms are spatially clustered. This effect is further augmented when they cluster around the port. Co-location of firms near the port tends to increase “bargaining power of buyers”, whilst indirectly affecting “competitive rivalry” via “threats of substitutes”. This indicates that co-location enhances the bargaining power of buyers through the greater availability of substitute services that in turn promotes competitive rivalry among firms. However, co-location has an insignificant effect on “barriers to entry” and “bargaining power of suppliers”. Low entry barrier thus favours high competitive rivalry among firms. Hence, this paper validates the Porter's cluster and five forces models that confirm the positive effect of port logistics clusters (PLCs) on bargaining power of buyers and indirect effect on competitive rivalry partially mediated through threats of substitutes.Practical implicationsThis study provides empirically grounded evidence for firms to evaluate co-location decision choices and help buyers and sellers to devise business strategies to enhance inter-firm competitive rivalry and bargaining power.Originality/valueThis is the first systematic attempt to empirically validate Porter's five forces model in the context of PLC. Furthermore, the conceptualisation of PLC concept both as spatial and functional constructs (i.e. dependency on port) is novel. This study thus has broadened the meaning of cluster from a geographic entity to a more useful functional construct to reflect inter-firm dependencies.