bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systolic blood pressure trajectories after acute ischemic strokes and clinical outcomes: A systematic review
Authors: Chen Xiuhua , Liu Huiliang , Ye Hongyuan , Bian Zhe , Peng Yanbo 
Published: July 2022

AbstractBlood pressure(BP) varies drastically during the acute phase after stroke onset. BP level and BP variability may have a major impact on acute ischemic stroke (AIS) prognosis. However, the association between trajectories of blood pressure over time and clinical outcomes have not been established. This review sought out existing evidences for associations of systolic blood pressure (SBP) trajectories on outcomes after stroke to determine the connection between SBP trajectories and stroke prognosis. According to a pre‐designed search strategy, literature search was carried out in Embase, Pubmed and Web of Science. Two authors independently evaluated study eligibility and quality, and literature data were extracted. When the literature was eligible, we perform meta‐analysis to determine associations of SBP trajectories with clinical outcomes. Seven studies were finally screened out of 52 studies retrieved. Seven studies received a good risk of bias rating and reported BP measurement methods and intervals, BP trajectories modeling methods, outcome measures, but it was found that final systolic BP trajectories in various papers were significantly different. All studies reported statistically significant associations between systolic blood pressure trajectories and prognosis. Methodological heterogeneity is observed in studies. However, this systematic review suggests that the high SBP group after AIS is related to poor clinical outcomes, while the rapid decline or medium‐to‐low or low SBP group is associated with relatively better clinical outcomes at different period after stroke. More prospective studies are needed to report the full methodology according to standardized criteria and explore relationships between SBP trajectories and prognosis of stroke.
Identification of red jujube varieties based on hyperspectral imaging technology combined with CARS‐IRIV and SSA‐SVM
Authors: Wang Simin , Sun Jun , Fu Lvhui , Xu Min , Tang Ningqiu , Cao Yan , Yao Kunshan , Jing Jianpeng 
Published: July 2022

AbstractTo identify the varieties of red jujube rapidly and nondestructively, hyperspectral imaging (HSI) technology was applied in this article. Hyperspectral data of 480 samples with four different varieties were acquired in the range of 400.68–1001.61 nm. First, Savitzky–Golay and standard normal variable were utilized to process raw spectra. Afterward, a novel method combining competitive adaptive reweighted sampling and iterative retained information variable (CARS‐IRIV) was proposed to select feature wavelengths. The support vector machine (SVM) modeling results indicated that CARS‐IRIV had better information extraction performance and simplified the model. Finally, to further improve the accuracy, sparrow search algorithm (SSA) was adopted to optimize the parameters (c, g) of SVM. The results showed that SSA‐SVM exhibited greater accuracy than other compared models, and the accuracy of training and test sets were 100% and 96.68%, respectively. It confirmed that HSI technology coupled with CARS‐IRIV‐SSA‐SVM can effectively identify varieties of red jujube.Practical ApplicationsThe traditional ways of classifying red jujube varieties are destructive and laborious. Therefore, HSI technology was adopted to overcome the above shortcomings. In this article, the best identification performance was based on the CARS‐IRIV‐SSA‐SVM model with an identification accuracy of 96.68%. This study is helpful for the identification of other agricultural product varieties by HSI technology.
Novel pathway regarding good cosmetics brands by NFT in the metaverse world
Authors: Lee Jinkyung , Kwon Ki Han 
Published: July 2022

AbstractBackgroundGlobally, the coronavirus disease‐19 (COVID‐19) is an incomplete homework task. The society has transitioned into a non‐face‐to‐face society due to COVID‐19. Thus, research was conducted focusing on a new market in the cosmetic market using non‐fungible token (NFT) in the metaverse era, a virtual world that is starting anew.PurposeThis study is an empirical analysis focused on introducing the new start of luxury cosmetics brands using the metaverse world to good consumption using NFT.MethodThese data were reviewed to identify agreement between each section and unique guiding areas. The 39 papers were finally considered appropriate for evaluating the research objectives as follows in relation to the search criteria. This can be done through the PRISMA flow diagram to determine how many records were identified, included, and excluded.ResultGood consumption in the future beauty market is vital, following COVID‐19. Therefore, this narrative review article concluded that, only good, irreplaceable brands that utilize NFT fitting the luxury brand strategy and consuming good money will survive when the metaverse cosmetic era opened.ConclusionBy identifying new changes in the global metaverse world and cosmetics market using NFT, this study can be used as an important marketing material in the metaverse cosmetics market.
Optimal gestational weight gain to reduce the risk of hypertension disorders of pregnancy among women with obesity: A single tertiary referral center study in Japan
Authors: Sugeno Misa , Kyozuka Hyo , Murata Tsuyoshi , Hiraiwa Tsuyoshi , Jin Toki , Fujimori Mimori , Fukumoto Yuki , Ito Fumihiro , Suzuki Daisuke , Toma Fukuda , Yasuda Shun , Fujimori Keiya , Nomura Yasuhisa 
Published: July 2022

AbstractAimTo examine the effect of weight gain during pregnancy on hypertension disorders of pregnancy among women with a prepregnancy body mass index ≥30.0 kg/m2.MethodsThis retrospective cohort study included 257 Japanese women (116 primipara; 141 multipara) with singleton pregnancies with a prepregnancy body mass index ≥ 30.0 kg/m2, who gave birth during 2013 to 2020 at Ohta Nishinouchi Hospital. Multiple logistic regression analyses were performed to identify the effect of gestational weight gain on early‐onset (<34 weeks), late‐onset (≥34 weeks), and overall hypertension disorders of pregnancy.ResultsThe prevalence of hypertension disorders of pregnancy in primiparas and multiparas was 28.4% and 11.3%, respectively. By multiple logistic regression analysis, gestational weight gain during pregnancy increased the risk of early‐onset (adjusted odds ratio: 1.20, 95% confidence interval: 1.03–1.39, p < 0.05) and overall hypertension disorders of pregnancy (adjusted odds ratio: 1.12, 95% confidence interval: 1.03–1.22, p < 0.05) among primiparas. Based on receiver operating characteristic curve analyses for early‐onset (area under the curve 0.67, 95% confidence interval: 0.56–0.78; p < 0.05) and overall hypertension disorders of pregnancy (area under the curve 0.76, 95% confidence interval: 0.61–0.91; p < 0.05) among primiparas, we determined the cut‐off weight gain during pregnancy for early‐onset and overall hypertension disorders of pregnancy as 3.85 kg, with sensitivity/specificity of 0.76/0.59 and 0.91/0.53, respectively.ConclusionWe recommend that the optimal gestational weight gain for reducing HDP be under 3.85 kg. This information may facilitate personalized pre‐conception counseling among women with obesity.
Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism: A pooled analysis of two randomized controlled trials
Authors: Lyko Christina , Blum Manuel R. , Abolhassani Nazanin , Stuber Mirah J. , Del Giovane Cinzia , Feller Martin , Moutzouri Elisavet , Oberle Jolanda , Jungo Katharina T. , Collet Tinh‐Hai , den Elzen Wendy P. J. , Poortvliet Rosalinde K. E. , Du Puy Robert S. , Dekkers Olaf M. , Trompet Stella , Jukema J. Wouter , Aujesky Drahomir , Quinn Terry , Westendorp Rudi , Kearney Patricia M. , Gussekloo Jacobijn , Van Heemst Diana , Mooijaart Simon P. , Bauer Douglas C. , Rodondi Nicolas 
Published: July 2022

AbstractBackgroundAntithyroid antibodies increase the likelihood of developing overt hypothyroidism, but their clinical utility remains unclear. No large randomized controlled trial (RCT) has assessed whether older adults with subclinical hypothyroidism (SHypo) caused by autoimmune thyroid disease derive more benefits from levothyroxine treatment (LT4).ObjectiveTo determine whether older adults with SHypo and positive antibodies derive more clinical benefits from LT4 than those with negative antibodies.MethodsWe pooled individual participant data from two RCTs, Thyroid Hormone Replacement for Untreated Older Adults with Subclinical Hypothyroidism and IEMO 80+. Participants with persistent SHypo were randomly assigned to receive LT4 or placebo. We compared the effects of LT4 versus placebo in participants with and without anti–thyroid peroxidase (TPO) at baseline. The two primary outcomes were 1‐year change in Hypothyroid Symptoms and Tiredness scores on the Thyroid‐Related Quality‐of‐Life Patient‐Reported Outcome Questionnaire.ResultsAmong 660 participants (54% women) ≥65 years, 188 (28.5%) had positive anti‐TPO. LT4 versus placebo on Hypothyroid Symptoms lead to an adjusted between‐group difference of −2.07 (95% confidence interval: −6.04 to 1.90) for positive antibodies versus 0.89 (−1.76 to 3.54) for negative antibodies (p for interaction = 0.31). Similarly, there was no treatment effect modification by baseline antibody status for Tiredness scores—adjusted between‐group difference 1.75 (−3.60 to 7.09) for positive antibodies versus 1.14 (−1.90 to 4.19) for negative antibodies (p for interaction = 0.98). Positive anti‐TPO were not associated with better quality of life, improvement in handgrip strength, or fewer cardiovascular outcomes with levothyroxine treatment.ConclusionsAmong older adults with SHypo, positive antithyroid antibodies are not associated with more benefits on clinical outcomes with LT4.
Analysis of genetic variants of frequently mutated genes in human papillomavirus‐negative primary head and neck squamous cell carcinoma, resection margins, local recurrences and corresponding circulating cell‐free DNA
Authors: Flach Susanne , Kumbrink Jörg , Walz Christoph , Hess Julia , Drexler Guido , Belka Claus , Canis Martin , Jung Andreas , Baumeister Philipp 
Published: July 2022

AbstractBackgroundHead and neck squamous cell carcinoma remains a substantial burden to global health. Despite evolving therapies, 5‐year survival is <50% and unlike in other cancers, reliable molecular biomarkers to guide treatment do not exist.MethodsWe performed targeted panel next‐generation sequencing to analyse somatic variants from primary and recurrent tumour tissue, corresponding resection margins and cell‐free DNA from intra‐operatively collected plasma samples from eight patients with human papillomavirus‐negative head and neck squamous cell carcinoma. Patients were primarily treated with curative‐intent surgery and received subsequent adjuvant treatment.ResultsThe most frequently mutated gene was TP53. Other mutated genes included NOTCH1, NF1 and CDKN2A among others. A total of 20.8% of variants were shared between primary tumour and resection margin. Out of all the variants detected, 37.5% were shared between cell‐free DNA and primary tumour, whereas 12.5% were commonly found in cell‐free DNA, primary tumour and resection margin. Mutational profiling was able to distinguish between a locoregional recurrence and a second primary tumour by identifying a different TP53 mutation in the primary tumour compared to the recurrent tumour in addition to private FBXW7 and CTNNB1 mutations. We also identified identical TP53 and PIK3CA mutations in another primary tumour and corresponding recurrence.ConclusionMolecular profiling of cell‐free DNA and resection margins has potential applications in clinical practice to guide future treatment decisions.
No size‐dependent net particle retention in the hindgut of horses
Authors: Schwarm Angela , Clauss Marcus , Ortmann Sylvia , Jensen Rasmus B. 
Published: July 2022

AbstractSieve analyses of hindgut contents of horses as well as observations in horses where plastic markers had been applied to a caecal cannula suggested that there may be a discrimination by particle size in the passage or retention of digesta. Here, we performed a similar experiment with five caecum‐cannulated horses (562 ± 31 kg) fed a constant amount (6.81 kg dry matter/day) of grass hay. Passage markers representing the liquid (Co‐EDTA) as well as the particulate digesta phase (Yb—undefined; Cr mordanted fibre 1−2 mm; Ce‐mordanted fibre 8 mm) were given as a pulse‐dose into the cannula to measure their mean retention times (MRT). The MRTs were compared by repeated‐measurements analysis of variance. The MRT in the hindgut was 22.2 ± 2.4 h for Co, 25.0 ± 3.4 h for Yb, 26.2 ± 1.6 h for Cr and 26.3 ± 1.5 h for Ce. Whereas differences between the particle marker MRTs were not significant (padj. > 0.05), significant differences were observed between the solute marker Co and each of the particle markers Cr and Ce (padj. < 0.009). The results confirm the well‐known significant, albeit small, difference in MRT in horses between the fluid and the particle digesta phase, and corroborate another recent study that used a combination of whole, marked hay and individual marker analysis in different particle size fractions of the faeces, which also did not detect a selective retention of any particle size class.
Integration of a social cluster of Atlantic spotted dolphins (Stenella frontalis) after a large immigration event in 2013
Authors: Elliser Cindy R. , Volker Cassandra L. , Herzing Denise L. 
Published: July 2022

AbstractDemographic changes can result in alterations of social structure and behavior which in turn may affect survival, reproduction, or movement and may influence how populations respond to changes in the environment. In 2013, 52 Atlantic spotted dolphins (Stenella frontalis) left Little Bahama Bank (LBB) and immigrated into a resident group of spotted dolphins on Great Bahama Bank (GBB). Initially there was little interaction and two distinct social clusters delineated by residency status. Here we describe the social structure of the dolphins on GBB between 2015–2020. Analyses were conducted with SOCPROG 2.9 and coefficients of association were nonrandom. The number of associations between LBB and GBB individuals increased, and standardized lagged association rates indicated continued associations over time. Modularity analysis showed one community without clear social clusters, although there were preferential associations within the original communities. Multiple Regression Quadratic Assignment Procedure indicated that sex, age, and residency status were good predictor variables that explained the patterns of the association indices. Male alliances were present between LBB, GBB, and LBB/GBB males. New and old relationships are influencing the social restructuring of this community. This study furthers our understanding of how demographic changes can shape the social structure of a population.
Respiratory chain dysfunction in perifascicular muscle fibres in patients with dermatomyositis is associated with mitochondrial DNA depletion
Authors: Hedberg‐Oldfors Carola , Lindgren Ulrika , Visuttijai Kittichate , Lööf Daniel , Roos Sara , Thomsen Christer , Oldfors Anders 
Published: July 2022

AbstractAimsPatients with dermatomyositis (DM) suffer from reduced aerobic metabolism contributing to impaired muscle function, which has been linked to cytochrome c oxidase (COX) deficiency in muscle tissue. This mitochondrial respiratory chain dysfunction is typically seen in perifascicular regions, which also show the most intense inflammatory reaction along with capillary loss and muscle fibre atrophy. The objective of this study was to investigate the pathobiology of the oxidative phosphorylation deficiency in DM.MethodsMuscle biopsy specimens with perifascicular COX deficiency from five juveniles and seven adults with DM were investigated. We combined immunohistochemical analyses of subunits in the respiratory chain including complex I (subunit NDUFB8), complex II (succinate dehydrogenase, subunit SDHB) and complex IV (COX, subunit MTCO1) with in situ hybridisation, next generation deep sequencing and quantitative polymerase chain reaction (PCR).ResultsThere was a profound deficiency of complexes I and IV in the perifascicular regions with enzyme histochemical COX deficiency, whereas succinate dehydrogenase activity and complex II were preserved. In situ hybridisation of mitochondrial RNA showed depletion of mitochondrial DNA (mtDNA) transcripts in the perifascicular regions. Analysis of mtDNA by next generation deep sequencing and quantitative PCR in affected muscle regions showed an overall reduction of mtDNA copy number particularly in the perifascicular regions.ConclusionThe respiratory chain dysfunction in DM muscle is associated with mtDNA depletion causing deficiency of complexes I and IV, which are partially encoded by mtDNA, whereas complex II, which is entirely encoded by nuclear DNA, is preserved. The depletion of mtDNA indicates a perturbed replication of mtDNA explaining the muscle pathology and the disturbed aerobic metabolism.
Outcomes addressed in randomized controlled lifestyle intervention trials in community‐dwelling older people with (sarcopenic) obesity—An evidence map
Authors: Galicia Ernst Isabel , Torbahn Gabriel , Schwingshackl Lukas , Knüttel Helge , Kob Robert , Kemmler Wolfgang , Sieber Cornel C. , Batsis John A. , Villareal Dennis T. , Stroebele‐Benschop Nanette , Visser Marjolein , Volkert Dorothee , Kiesswetter Eva , Schoene Daniel 
Published: July 2022

SummaryObesity and sarcopenic obesity (SO) are characterized by excess body fat with or without low muscle mass affecting bio‐psycho‐social health, functioning, and subsequently quality of life in older adults. We mapped outcomes addressed in randomized controlled trials (RCTs) on lifestyle interventions in community‐dwelling older people with (sarcopenic) obesity. Systematic searches in Medline, Embase, Cochrane Central, CINAHL, PsycInfo, Web of Science were conducted. Two reviewers independently performed screening and extracted data on outcomes, outcome domains, assessment methods, units, and measurement time. A bubble chart and heat maps were generated to visually display results. Fifty‐four RCTs (7 in SO) reporting 464 outcomes in the outcome domains: physical function (n = 42), body composition/anthropometry (n = 120), biomarkers (n = 190), physiological (n = 30), psychological (n = 47), quality of life (n = 14), pain (n = 4), sleep (n = 2), medications (n = 3), and risk of adverse health events (n = 5) were included. Heterogeneity in terms of outcome definition, assessment methods, measurement units, and measurement times was found. Psychological and quality of life domains were investigated in a minority of studies. There is almost no information beyond 52 weeks. This evidence map is the first step of a harmonization process to improve comparability of RCTs in older people with (sarcopenic) obesity and facilitate the derivation of evidence‐based clinical decisions.
Myopia control with dual‐focus soft contact lenses during the first year of measures to contain the COVID‐19 pandemic
Authors: Cabanes‐Martí Emma , García‐Ayuso Diego 
Published: July 2022

AbstractPurposeThis study compared refractive and axial length (AL) changes in children wearing dual‐focus soft contact lenses for myopia control (MiSight®) with myopic children wearing spectacles one year from the start of lockdown during the COVID‐19 pandemic.MethodsThis retrospective, descriptive, parallel‐group, observational study reviewed the charts of 11 children who began treatment for myopia control with dual‐focus soft contact lenses for myopia control (MiSight®) in March 2020 and 11 matched spectacle‐wearing controls. The mean increase in spherical equivalent refraction (SER) and AL from the beginning of the lockdown and up to 1 year later were compared. The parents of the children were asked about the average time spent on near work, contact lens wearing time both during and after the strict confinement and whether they had discontinued contact lens wear during lockdown.ResultsDuring this first year of preventive COVID‐19 measures (March 2020–March 2021), for the contact lens group the average SER and AL increased −0.14 ± 0.09D and 0.13 ± 0.05 mm, respectively. For the spectacle wearers, the corresponding increases were −0.54 ± 0.16D and 0.25 ± 0.08 mm, respectively. A significant difference was found between the groups for both SER (p < 0.001) and AL (p < 0.05). The average time spent outdoors was restricted for both groups during lockdown and increased after. However, statistically significant changes in the time spent outdoors during and after lockdown were only found for the spectacle group (p < 0.05; t‐test), whereas this change was not significant for the contact lens group (p = 0.08).ConclusionsOver the observed time period, dual‐focus soft contact lenses for myopia control were effective despite the decreased time spent outdoors during the COVID‐19 pandemic.
Tongue Manifestation in Patients with Osteonecrosis of the Femoral Head: A Cross‐sectional Study
Authors: Jia Yan , Sun Jigao , Jia Zhaoxu , Xue Zhipeng , Wang Rongtian , He Haijun , Chen Weiheng 
Published: July 2022

ObjectiveAlthough tongue manifestation is a vital component of Traditional Chinese Medicine (TCM), relevant research on patients with osteonecrosis of the femoral head (ONFH) is still lacking. This study will explore the characteristic tongue manifestation of ONFH patients to inform future research and clinical practice.MethodsThis is a cross‐sectional study. All ONFH patients meeting criteria and their clinical data were collected from the online China osteonecrosis of the femoral head database (CONFHD) since it was created. Organized tongue manifestations of eligible patients through the tongue manifestation acquisition instrument, including tongue shape, tongue color, tongue coating thickness, tongue coating color and tongue coating moisture. We used descriptive analysis for the general information while systematic clustering analysis for the better summary of tongue characteristics.ResultsA total of 375 ONFH patients were included with an average age of 46.3 years. Most patients appeared with enlarged tongue body (54.4%), and the proportions of pale and red tongue (62.4%) were higher than others. Tongue coating were mainly showed as thick (64.5%), white (57.6%) and moist (79.7%). Comparison of tongue shape between different causes of ONFH had a significant statistically difference (P = 0.000). Tongue manifestations could be cluster analyzed into three categories which were matched into four TCM syndromes.ConclusionsThe tongue manifestation of ONFH patients has a significant change both in tongue body and coating, and different features may be related to the ONFH pathology. This study provides new and valuable tongue informations for a preliminary screening of ONFH patients.