bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assembly of neuron- and radial glial cell-derived extracellular matrix molecules promotes radial migration of developing cortical neurons
Authors: Mubuchi Ayumu , Takechi Mina , Nishio Shunsuke , Matsuda Tsukasa , Itoh Yoshifumi , Sato Chihiro , Kitajima Ken , Kitagawa Hiroshi , Miyata Shinji 
Published: September 2022

AbstractRadial neuronal migration is a key neurodevelopmental event for proper cortical laminar organization. The multipolar-to-bipolar transition, a critical step in establishing neuronal polarity during radial migration, occurs in the subplate/intermediate zone (SP/IZ), a distinct region of the embryonic cerebral cortex. It has been known that the extracellular matrix (ECM) molecules are enriched in the SP/IZ. However, the molecular constitution and functions of the ECM formed in this region remain poorly understood. Here, we identified neurocan (NCAN) as a major chondroitin sulfate proteoglycan in the SP/IZ. NCAN binds to both radial glial cell-derived tenascin-C (TNC) and hyaluronan (HA), a large linear polysaccharide, forming a ternary complex of NCAN, TNC, and HA in the SP/IZ. Developing cortical neurons make contact with the ternary complex during migration. The enzymatic or genetic disruption of the ternary complex impairs radial migration by suppressing the multipolar-to-bipolar transition. Furthermore, both TNC and NCAN promoted the morphological maturation of cortical neuronsin vitro. The present results provide evidence for the cooperative role of neuron- and radial glial cell-derived ECM molecules in cortical development.
Frequency and Risk Factors of Resident Burnout Before and During the COVID19 Pandemic
Authors: Türk Sevcan , Kalyoncu Anıl , Karabilgin Öztürkçü Özlem Sürel , Elbi Hayriye , Orman Mehmet Nurullah , Yaman Aziz Cem , Toptaş Muratcan , Bekki Yaşar Çağlar , Özlütaş Murat , Esentürk Mehmet Burak , Bapuraj Jayapalli , Özbek Süha Süreyya 
Published: September 2022

AbstractObjectiveTo explore the prevalence and contributing factors of resident burnout in a University Hospital before and during the COVID 19 pandemic.MethodsThirty Faculty of Medicine departments were included in the survey, where 400 university hospital residents filled out the Maslach Burnout Inventory (MBI) in January 2018 and April 2020. Related scores of emotional exhaustion (EE), decreased accomplishment (DA) and depersonalization (DP) were calculated and compared between the different groups. Correlation between scores and possible contributing factors, including demographics, work-life circumstances, exposure to workplace violence, were investigated. Contributing factors were compared between the time points.ResultsThe EE and DA scores were significantly higher in junior residents than in senior residents. Both scores were higher among residents who had experienced abuse or violence. The emergency medicine residents had significantly higher DP scores, while the EE scores of radiology residents were lower than others. Thirty percent of all residents smoked cigarettes. This percentage was even higher among the residents of the departments of surgery and emergency medicine (45-50%). A significant correlation was demonstrated between the scores of MBI and smoking, while analysis with other demographics did not yield any relation. According to the study results, basic science residents had significantly increased scores in all MBI subgroups during the pandemic.ConclusionResident physician burnout was found to be related to the work environment, smoking cigarettes and exposure to violence at workplace.
A rapid review of the effectiveness of remote consultations versus face-to-face consultations in secondary care surgical outpatient settings
Authors: Edwards Deborah , Csontos Judit , Gillen Liz , Carrier Judith , Lewis Ruth , Cooper Alison , Edwards Adrian 
Published: September 2022

AbstractThe use of remote consultations and telemedicine approaches significantly increased over the pandemic. There is evidence that some patients still prefer this mode of care delivery and time saving may also enable additional consultations and help to reduce waiting lists. However, the effectiveness of remote consulting for certain specialities, such as surgery, is unclear.The aim of this review was to investigate the effectiveness of video or telephone consultations, particularly focusing on clinical, patient reported and safety outcomes, in adult secondary surgical outpatient care during the COVID-19 pandemic.14 studies were identified. These were published in 2021-2022. Evidence is low or very-low quality due to observational study designs, small sample sizes and patient selection.Policy and practice implications: Evidence is of low quality but suggests that for many surgical outpatient consultations, remote consultations are as effective as in-person consultations. There is potential for time and cost savings for remote consultations compared to in-person consultations. High quality research is needed to evaluate the effectiveness of remote consultations to understand which patients and which surgical specialities would benefit most.Funding statementThe Wales Centre for Evidence Based Care was funded for this work by the Wales COVID-19 Evidence Centre, itself funded by Health & Care Research Wales on behalf of Welsh Government.
Association between visit-to-visit lipid variability and incident cancer: a population-based cohort study
Authors: Chan Jeffrey Shi Kai , Satti Danish Iltaf , Lee Yan Hiu Athena , Waleed Khalid Bin , Tang Pias , Mahalwar Gauranga , Minhas Abdul Mannan Khan , Roever Leonardo , Biondi-Zoccai Giuseppe , Leung Fung Ping , Wong Wing Tak , Liu Tong , Zhou Jiandong , Tse Gary 
Published: September 2022

AbstractBackgroundDyslipidaemia is associated with increased cancer risk. However, the prognostic value of visit-to-visit lipid variability (VVLV) is unexplored in this regard.ObjectiveTo investigate the associations between VVLV and the risk of incident cancer.DesignRetrospective cohort study.SettingFamily medicine clinics.PatientsAdults attending a family medicine clinic in Hong Kong during 2000-2003, excluding those with <3 tests for low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, and total cholesterol (TC) each, those with prior cancer diagnosis, and those with <1 year of follow-up.MeasurementsVisit-to-visit LDL-C, HDL-C, TC, and triglycerides variabilities were measured by the coefficient of variation (CV). Patients were followed up until 31stDecember 2019 for the primary outcome of incident cancer.ResultsAltogether, 69,186 patients were included (26,679 males (38.6%); mean age 60±13 years; mean follow-up 16±3 years); 7958 patients (11.5%) had incident cancer. Higher variability of LDL-C, HDL-C, TC, and TG was associated with higher risk of incident cancer. Patients in the third tercile of the CV of LDL-C (adjusted hazard ratio (aHR) against first tercile 1.06 [1.00, 1.12], p=0.049), HDL-C (aHR 1.37 [1.29, 1.44], p<0.001), TC (aHR 1.10 [1.04, 1.17], p=0.001), and TG (aHR 1.11 [1.06, 1.18], p<0.001) had the highest risks of incident cancer. Among these, only HDL-C variability remained associated with the risk of incident cancer in users of statins/fibrates.LimitationsDue to the observational nature of this study, there may be residual and unmeasured confounders. Patient data could not be individually adjudicated, implying that coding errors may be possible.ConclusionHigher VVLV was associated with significantly higher long-term risks of incident cancer. VVLV may be a clinically useful tool for cancer risk stratification.
Anticholinergic burden in middle and older age is associated with lower cognitive function, but not with brain atrophy
Authors: Mur J. , Marioni R. E. , Russ T. C. , Muniz-Terrera G. , Cox S. R. 
Published: September 2022

AbstractBackgroundAnticholinergic drugs block muscarinic receptors in the body. They are commonly prescribed for a variety of indications and their use has previously been associated with dementia and cognitive decline.MethodsUK Biobank participants with linked health-care records (n=163,043, aged 40-71 at baseline), for about 17,000 of which MRI data was available, we calculated the total anticholinergic drug burden according to 15 different anticholinergic scales and due to different classes of drugs. We then used linear regression to explore the associations between anticholinergic burden and various measures of cognition and structural MRI, including general cognitive ability, 9 separate cognitive domains, brain atrophy, volumes of 68 cortical and 14 subcortical areas, and fractional anisotropy and median diffusivity of 25 white-matter tracts.ResultsAnticholinergic burden was modestly associated with poorer cognition across most anticholinergic scales and cognitive tests (7/9 FDR-adjusted significant associations, standardised betas (β) range: −0.039, −0.003). When using the anticholinergic scale exhibiting the strongest association with cognitive functions, anticholinergic burden due to only some classes of drugs exhibited negative associations with cognitive function, with β-lactam antibiotics (β=-0.035, pFDR<0.001) and opioids (β=-0.026, pFDR<0.001) exhibiting the strongest effects. Anticholinergic burden was not associated with any measure of brain macro- or microstructure (pFDR>0.08).DiscussionAnticholinergic burden is weakly associated with poorer cognition, but there is little evidence for associations with brain structure. Future studies might focus more broadly on polypharmacy or more narrowly on distinct drug classes, instead of using purported anticholinergic action to study the effects of drugs on cognitive ability.
Impacts of host city image in the country destination branding in sport mega-event context: exploring cognitive and affective image dimensions
Authors: Ferreira Luciana Brandão , Giraldi Janaina de Moura Engracia , Maheshwari Vish , Oliveira Jorge Henrique Caldeira de 
Published: September 2022

PurposeThis paper aims to verify the brand image effects of holding a sport mega-event by investigating the host city's influence on the country's branding, as a tourist destination.Design/methodology/approachThis research considered the Rio 2016 Olympic Games and uses quantitative methods: exploratory factor analysis and regression. Data were collected by structured questionnaires with a sample of (n = 274) international respondents with high international travel experience.FindingsRio de Janeiro's 2016 host city image positively predicted Brazil's tourist destination image. Both cognitive and affective image dimensions of Rio as a host city predicted Brazil's destination image, but the cognitive image dimensions demonstrated more impact.Practical implicationsEven in a mega-event context, city marketing strategies should be planned and executed with a focus on the country's destination image.Originality/valueThe study contributes by focusing on presenting the importance of the host city image dimensions to the host country destination image in a sports mega-event context. The study investigated a new approach, the impacts of affective and cognitive dimensions in the overall destination image considering two connected destinations and the hosting of a sport mega-event, a condition not found in the literature thus far.
Predicting complaint voicing or exit amidst Indian consumers: a CHAID analysis
Authors: Kumar Amit , Kaur Anupriya 
Published: September 2022

PurposeThe current study aims to predict consumer complaint status (complainers or non-complainers) based on socio-demographic and psychographic factors and further to discern the differences in behavior disposition of consumer groups concerning determinants of consumer's tendency to exit (TE).Design/methodology/approachThe research used survey-based data of 600 Indian consumers of three service sectors (hotel and hospitality, automobile service centers and organized retail stores). Chi-square automatic interaction detector (CHAID) decision tree analysis was used to profile consumers.FindingsThe results indicated that occupation; income; education; industry and attitude toward complaining were significant factors in profiling consumers as complainers or non-complainers. Further, determinants of TE (discouraging subjective norms, perceived likelihood of successful complaint, lower perceived switching cost, poor employee response, negative past experience and ease of complaint process) vary significantly across the groups of complainers and non-complainers.Research limitations/implicationsThe research questions in this study were tested with three service sectors consumers in India, so due care should be exercised in generalizing these findings to other sectors and countries. Study replication across other service sectors and countries is recommended to improve the generalizability of these findings with wider socio-demographic samples.Practical implicationsFirms striving for consumer retention and aim to extend their consumer life cycle can greatly benefit from the results of this study to understand the customer complaint behavior (CCB) specific to non-complaining (exit) behavior. The future researcher may benefit from replicating and extending the model in different industries for further contribution to the CCB literature.Originality/valueTo the best of the author's knowledge, there is no evidence of consumer segmentation based on their complaining behavior or socio-demographic and psychographic factors by employing CHAID decision tree analysis. In addition to illustrating the use of data mining techniques such as CHAID in the field of CCB, it also contributes to the extant literature by researching in a non-Western setting like India.
Twentieth-century built urban heritage potential of the Somali region, its management, challenges and opportunities: the case of Jigjiga, Qebridahar and Erer cities
Authors: Yasien Muhammed Hamid , Kebede Tesfamichael Teshale 
Published: September 2022

PurposeThe research works concerned with heritage management, in general, are available domestically and globally, but they are not as abundant as required when it comes to the management of twentieth-century urban heritages, particularly the Somali region. Thus, this research is assumed as innovative and evocative of additional research initiatives in the management of twentieth-century urban heritages, and it can assure the development of sustainable heritage tourism in the research area.Design/methodology/approachThe study employed a cross-sectional survey as the research design, and qualitative data of both primary and secondary types were collected for this research. Therefore, purposively selected knowledgeable individuals in heritages of the study area were involved in in-depth interviews and focus group discussions, and field surveys of twentieth-century built urban heritage sites were conducted in Jigjiga, Erer and Qebridahar cities. Generally, observation, face-to-face interview interviews and focused group discussions were used to collect primary data, and document analysis was also used to collect secondary data.FindingsThe findings of the study revealed that the Somali region is rich in twentieth-century urban built heritage. The imperial palace, administrative centers, mosques, shrines, churches, military camps, Italian-built architecture sites, patriot centers, statues of local heroes, older bus stations and city centers are among the twentieth-century built heritages in the region. However, most of these heritages were not recognized. Consequently; conservation, promotion and use of the twentieth-century urban heritages for sustainable development are given little attention despite that there are infrastructural facilities for tourists in the region and the proximity of the region to the heritage tourism corridors of Harar and Dire Dawa.Research limitations/implicationsAwareness should be made to the concerned institutions and societies about socio-economic and cultural values of the twentieth-century urban built heritage.Practical implicationsThe Federal Culture and Tourism Ministry and Culture and Tourism Bureau of the Somali region should cooperatively develop a short and long-term plan of action to manage the twentieth-century built urban heritage of the region and use them for sustainable development through the participation of the society.Social implicationsThe local institutions, communities and individuals should be aware of and involved in the conservation, promotion and use of the twentieth-century built urban heritages for sustainable social, cultural and economic development.Originality/valueAs far as the researchers' knowledge is concerned, there is no research of a similar type in which the setting and results are closer to this. Therefore, this research is original and is based on extensive primary data gathered from field surveys.
Determinants of becoming an M&A acquirer or target: evidence from the US insurance industry
Authors: Özer Gökhan , Okur Nurullah , Çam İlhan 
Published: September 2022

PurposeThis paper explores which fundamental aspects of US insurance firms are significant factors in determining whether a firm will be a target or acquirer firm.Design/methodology/approachBy focusing on 251 mergers and acquisitions (M&A) deals (119 target firms and 132 acquirer firms) over the period between 1990 and 2019, multinomial logistic regression results identify the determinants associated with becoming targets or acquirers.FindingsUS insurance firms are more likely to become targets if they are smaller, have lower cash holdings, are non-life, and do not have environmental, social and governance (ESG) scores. Insurance firms are more likely to be acquirers if they have higher profitability, higher cash flow and higher intangibles, and if they are non-life and do not have ESG scores. Moreover, the likelihood of becoming an acquirer decreases in times of global financial crises (GFCs) as compared to non-GFC times.Originality/valueThis paper is the first to utilize multi-period multinomial logistic regression analysis to investigate the determinants of selection decisions of M&A targets and acquirers in the US insurance industry.
Design opportunities for future development of crisis communication technologies for marginalised groups – Co-designing with Swedish disability organisations
Authors: Nilsson Elisabet M. , Lundälv Jörgen , Eriksson Magnus 
Published: September 2022

PurposeThe purpose is to firstly, provide an example of how voices of people with various disabilities (motor, visual, hearing, and neuropsychiatric impairments) can be listened to and involved in the initial phases of a co-design process (Discover, Define). Secondly, to present the outcome of the joint explorations as design opportunities pointing out directions for future development of crisis communication technologies supporting people with disabilities in building crisis preparedness. The study was conducted during the Covid-19 pandemic.Design/methodology/approachThe study assumes a design research approach including a literature review, focus group interviews, a national online survey and collaborative (co-)design workshops involving crisis communicators and representatives of disability organisations in Sweden. The research- and design process was organised in line with the Double Diamond design process model consisting of the four phases: Discover, Define, Develop and Deliver, whereof the two first phases are addressed in this paper.FindingsThe analysis of the survey data resulted in a series of challenges, which were presented to and evaluated by crisis communicators and representatives from the disability organisations at the workshops. Seven crisis communication challenges were identified, for example, the lack of understanding and knowledge of needs, conditions and what it means to build crisis preparedness for people with disabilities, the lack of and/or inability to develop digital competencies and the lack of social crisis preparedness. The challenges were translated into design opportunities to be used in the next step of the co-design process (Develop, Deliver).Originality/valueThis research paper offers both a conceptual approach and empirical perspectives of design opportunities in crisis communication. To translate identified challenges into design opportunities starting with a “How Might We”, creates conditions for both researchers, designers and people with disabilities to jointly turn something complex, such as a crisis communication challenge, into something concrete to act upon. That is, their joint explorations do not stop by “knowing”, but also enable them to in the next step take action by developing potential solutions for crisis communication technologies for facing these challenges.
“School of precariousness”: the production of consent to precarious work in administration internships
Authors: Fuzyama Christian Kazuo , Lemos Ana Heloisa , Silva Marcelo Almeida de Carvalho 
Published: September 2022

PurposeThis study aims to understand the production of consent to precarious working conditions in administration students' internship experiences.Design/methodology/approachA total of 13 students of an undergraduate program in Business Administration in a private university were interviewed. The students' perceptions about the dynamics of the internship and their engagement in this experience were explored through thematic analysis.FindingsInternships became more than spaces to learn about the world of work. They are also the locus of professional socialization toward precarious work. The detachment of internships from their educational scope is mediated by neonormative control mechanisms that subjectively mobilize the interns, producing the institutionalization and appreciation of the precarious experience, resignified as something that leads to autonomy, learning and a job position.Practical implicationsThe article can help students, universities and companies to assess the role of internships in training future professionals.Social implicationsThe research problematizes the internship as a form of professional socialization toward precarious work and its detachment from the original educational purpose. The article critically contributes to the debate about the current professional socialization process of young students.Originality/valueThe article highlights the subjective dimension that supports students' consent to dysfunctional internships, discussing both the experience of work precariousness and exploitation, and the terms of the students' engagement in such dynamics, bridging consent to neonormative controls.