bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skin Temperature Correction for Calculations of Air‐Sea Oxygen Flux and Annual Net Community Production
Authors: Yang Bo , Emerson Steven R. , Cronin Meghan F. 
Published: February 2022

AbstractWe evaluated the influence of skin temperature correction on the calculations of air‐sea O2 flux and annual net community production (ANCP). The skin temperature correction term (ΔT) was derived from the fifth generation European Center for Medium‐Range Weather Forecasts Reanalysis, which has large spatial and temporal variations that are consistent with independent measurements on three ocean moorings from areas with very different air‐sea heat flux and ΔT. The result revealed that ΔT is dominated by the cool skin effect (which leads to the increase in air‐to‐sea O2 flux and decrease in ANCP), except for the equatorial region or summertime when the warm layer effect is significant. Using data from three Argo profiling floats in the subarctic, subtropical, and tropical Pacific as examples, the calculations indicated that the correction could lead to −1%–+36% difference in annual air‐to‐sea O2 flux and −33%–+5% difference in ANCP.
Admittance of the Earth Rotational Response to Zonal Tide Potential
Authors: Bizouard C. , Fernández L. I. , Zotov L. 
Published: February 2022

AbstractThis study is devoted to the determination of the admittance parameters describing the Earth rotational response to the components of the zonal tide potential. First, in order to better grasp the physical content of those admittance coefficients, we revisit the theoretical description of the length of day (LOD) changes at sub‐decadal time scale, where forcing is dominated by zonal tides and hydro‐atmospheric mass transports. This theoretical reminder specifies the rheological coefficients permitting to apply the hydro‐atmospheric corrections to isolate the tidal part of the LOD. Then, the admittances are determined from the LOD series corrected from hydro‐atmospheric contributions at the frequencies of the dominant zonal tidal terms between 7 and 365 days. In contrast of the former kindred studies, we both address the discrepancy of the results brought by various EOP series and the hydro‐atmospheric corrections on the LOD. Our study forwards the complementary corrections brought by the ocean, the land water and sea level changes. Below 32 days, removing the atmospheric‐oceanic excitation from LOD allows to much better constraint the admittance complex coefficients κ than applying the atmospheric correction only: the discrepancy with respect to modeled values is reduced up to 70%, and the frequency dependence of the imaginary part brought by the ocean dynamical response is confirmed. A systematic effect with respect to the values modeled by Ray and Erofeeva (2014), https://doi.org/10.1002/2013jb010830 has been detected and hints a defect of this model. Moreover, the role of land water and associated sea level variation is notable at the semi‐annual period.
Pourquoi le clinicien est-il en difficulté devant l’adolescent présentant une douleur musculo-squelettique chronique fonctionnelle ? Une étude qualitative
Authors: Loisel Alexandra , Lefèvre Hervé , Quartier Pierre , Lachal Jonathan 
Published: February 2022

Contexte : La prise en charge des douleurs musculo squelettiques fonctionnelles chroniques chez l’adolescent est souvent jugée difficile par les patients, leurs familles, et les professionnels eux-mêmes.
Objectifs : Explorer l’expérience des professionnels de santé sur la démarche diagnostique et le parcours de soins des douleurs musculo squelettiques chroniques inexpliquées chez l’adolescent et le jeune adulte (11-19 ans).
Méthode : Étude qualitative observationnelle menée dans trois centres hospitaliers universitaires de référence de rhumatologie de l’adolescent et du jeune adulte à l’aide d’une approche phénoménologique.
Participants : 25 professionnels médecins (rhumatologues, pédiatres, algologue, psychiatre, orthopédiste) ou paramédicaux (kinésithérapeutes, ostéopathes, ergothérapeutes, psychologues) ont été interrogés à l’aide d’entretiens semi-structurés.
Résultats : La douleur fonctionnelle est un diagnostic d’élimination sans être une entité nosologique, ce qui rend son affirmation difficile. La posture de méfiance réciproque entre le praticien, le patient et sa famille et la nécessité d’une approche pluridisciplinaire limite la constitution d’une alliance thérapeutique de bonne qualité. Sa prise en charge demande des compétences et des ressources difficiles d’accès.
Conclusion : Une approche holistique semble la plus constructive pour considérer ces douleurs. Les recherches sur la physiopathologie de la sensibilisation centrale sont prometteuses et pourraient être appliquées à la douleur fonctionnelle de l’adolescent
Why dealing with functional chronic musculoskeletal pain in adolescents is challenging for the clinician: a qualitative study
Antidiabetic Activity of Caulerpa racemosa: Role of
Proinflammatory Mediators, Oxidative Stress, and Other
Biomarkers
Authors: Mandlik Rahul V. , Naik Suresh R. , Zine Sandip , Ved Hemen , Doshi Gaurav 
Published: February 2022

AbstractA marine alga, Caulerpa racemose (seaweed), exhibits few biological
activities, such as antinociceptive/anti-inflammatory, antitumor, and
growth regulator. This study aimed to determine the antidiabetic activity of
this seaweed. High-performance thin-layer chromatography of C. racemosa
ethanolic extract was performed to identify its active constituents.
Antidiabetic activity of C. racemosa ethanolic extract (100 and
200 mg/kg) was evaluated using various biochemical paradigms
against glipizide (5 mg/kg) in a streptozotocin-induced diabetes
rat model. High-performance thin-layer chromatography revealed
β-sitosterol as an active constituent and also indicated the
presence of saponins and alkaloids. Treatment with C. racemosa ethanolic
extract significantly reduced blood glucose levels in diabetic rats, and the
degree of glucose reduction was comparable to that attained by glipizide
treatment. The C. racemosa ethanolic extract treatment restored the
impaired glycosylated hemoglobin level, liver glycogen level, glucose uptake by
hemidiaphragm, and glucose transport by hepatic cells. Pretreatment with C.
racemosa ethanolic extract also restored lipid abnormalities, elevated
liver enzymes, elevated inflammatory markers, and depleted endogenous
antioxidants. A superior effect was shown by C. racemosa ethanolic
extract (200 mg/kg) over glipizide (5 mg/kg).
Moreover, the restoration of the histoarchitecture of the pancreas by C.
racemosa ethanolic extract (200 mg/kg) was comparable to
that of the glipizide (5 mg/kg) treatment group. The present
experimental findings demonstrate significant antidiabetic activity of C.
racemosa ethanolic extract in diabetic rats using various biochemical
paradigms. Further, C. racemosa ethanolic extract seems to be safe and
does not affect vital organs adversely.
Influence of Metabolic Syndrome on the Recovery from Idiopathic Sudden Sensorineural Hearing Loss
Authors: Breda Miguel Sá , Menezes Ana Sousa , Oliveira Tiago Gil , Dias Luís 
Published: February 2022

Abstract
Introduction Idiopathic sudden sensorineural hearing loss (ISSHL) is a disabling otologic urgency whose ethiopathogenesis is still controversial. Only in recent years metabolic syndrome (MetS) has been implicated as a possible aggravating factor in the prognosis of recovery from ISSHL.
Objective To assess whether the preexistence of MetS interferes on hearing recovery levels.
Methods Retrospective cohort study composed of adult (> 18 years old) ISSHL patients admitted for treatment between January 2015 and December 2019. To diagnose ISSHL, we used pure-tone audiometry, and identified MetS patients based on the criteria of the United States National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). The treatment protocol comprised hospitalization for five days for the intravenous administration of dexamethasone, audiometric surveillance, imaging and blood analyses, and, based on recovery, the planning of rescue treatments (intratympanic administration of dexamethasone and/or hyperbaric oxygen). The Siegel criteria were used to evaluate the hearing outcomes.
Results The final sample was composed of 81 patients, 48 without MetS (nMetS) and 33 with MetS. Regarding the Siegel recovery category, the nMetS group had significantly better results (p = 0.001), with 44% of complete recoveries against 6% in the MetS, and 58% of the MetS patients had the worst outcome, contrasting with 27% in the nMetS group. The nMetS group had an overall better evolution in terms of hearing recovery and had a significant improvement in the median hearing gain (20.6 dB versus 8.8 dB; p = 0.008). Additionally, the multivariate analysis revealed that the presence of MetS is a significant risk factor for a worse outcome (odds ratio [OR] = 0.30; 95% confidence interval [95%CI] = 0.10–0.85).
Conclusion Regardless of age, gender, the initial audiometry threshold, and autoimmunity, MetS is a clear risk factor for a worse outcome regarding the recovery of hearing after ISSHL.
Health of the Newborn and Breastfeeding during the COVID-19 Pandemic: A Literature Review
Authors: Salvador-Pinos Carmen Amelia , Martinez Edson Zangiacomi , Dueñas-Matute Susana Eulalia , Aguinaga Rosa Romero de , Jácome Juan Carlos , Michelena-Tupiza Stephanie , Cárdenas-Morales Valheria 
Published: February 2022

Abstract
Objective The present article presents a literature review concerning the microbiota of breast milk and the influence of epigenetics in the susceptibility to COVID-19.
Methods A literature review.
Results Breastfeeding transfers microbiota, nutrients, diverse white blood cells, prebiotics, hormones, and antibodies to the baby, which provide short- and long-term immunological protection against several infectious, gastrointestinal, and respiratory illnesses. The little evidence available shows that breast milk very rarely carries the SARS-CoV-2 virus, and even in those cases, it has been discarded as the source of contagion.
Conclusion The reviewed studies show evidence of a beneficial effect of breastfeeding and highlights its importance on the current pandemic due to the immune reinforcement that it provides. Breastfed individuals showed better clinical response due to the influence on the microbiota and to the nutritional and immune contribution provided by breast milk, compared with those who were not breastfed.
Global governance and the Global Green New Deal: the G7’s role
Authors: Johnstone Injy 
Published: February 2022

AbstractCurrent headlines suggest that the world at large has missed the opportunity to ‘build back better’ from COVID-19 by way of a green recovery. However, such claims do not consider novel trends among plurilateral summit institutions, especially the extent to which global governance of a green recovery is encapsulated by the burgeoning norm bundle of the ‘Global Green New Deal’. Plurilateral summit institutions like the G20, G7 and the BRICS have the potential to play a key governance role in implementing a Global Green New Deal, given the breadth and depth of reform required to ‘build back better’ from COVID-19. This contribution adopts a practice-relationist methodology to explore this thesis. Green recovery practice is analysed through novel interrogation of the open-source stimulus spending data of the Global Recovery Observatory. The results reveal that the G7, the G20 and the BRICS are all funding proportionally more clean than dirty stimulus in response to COVID-19. However, the proportion of clean stimulus is much stronger among members of the G7. A relationist frame is then used to assess this practice against the potential norm entrepreneurship role of the G7, both as individual member states and as a collective. It concludes that although this norm entrepreneurship role is undoubtedly nascent, it yields valuable insights into the pathways and barriers for further norm diffusion of the Global Green New Deal among plurilateral summit institutions. In this way it highlights the unique role plurilateral summit institutions can play in not only globalising the green new deal, but crucially operationalising it. Thus, while the world may not yet be ‘building back better’ as a collective, it is institutional norm entrepreneurs who currently hold the blueprints.
Capsaicin prevents radiotherapy-induced premature ovarian failure in rats
Authors: Akdemir Yesim , Akpolat Meryem , Elmas Ozlem , Kececi Mete , Buyukuysal Cagatay , Cetinkaya Busra , Guleryuz Nurten 
Published: February 2022

Ionising radiation exposure of 5–10 gray (Gy) to the pelvic area induces premature ovarian failure (POF). Twenty-four young adult Wistar albino female rats were were treated with subcutaneous capsaicin 0.5 mg/kg per day or placebo for 10 days then exposed to whole body irradiation. Rats were randomly divided into four groups: (1) control; (2) capsaicin; (3) radiation only (IR): rats were injected with placebo before exposure to a single dose of 8.3-Gy whole body irradiation; (4) radiation–capsaicin (IR + CAP): rats were injected with capsaicin prior to whole body irradiation. Radiation triggered oxidative stress, increased ovarian inflammation, increased follicular apoptosis and diminished ovarian follicle pool. Capsaicin significantly ameliorated oxidative stress by decreasing serum total oxidant status, oxidative stress index, disulphide, and malondialdehyde levels (P ≤ 0.001); ovarian inflammatory status by decreasing expressions of TNF-α, IL-1β, PARP-1 (P = 0.002); apoptosis by decreasing expressions of active caspase-3 and p53 (P = 0.015, P = 0.002); and follicle counts by increasing primordial follicles and decreasing apoptotic follicles (P ≤ 0.001) in rats when administered before radiation exposure. The beneficial effects of capsaicin are demonstrated for the first time on ionising radiation exposed rat ovaries. Capsaicin pre-treatment before radiotherapy restores the primordial follicle pool, inhibits atresia of ovarian follicles and may be an acceptable therapeutic modality to prevent radiation-induced POF.
miR-182 targeting reprograms tumor-associated macrophages and limits breast cancer progression
Authors: Ma Chengxin , He Dasa , Tian Pu , Wang Yuan , He Yunfei , Wu Qiuyao , Jia Zhenchang , Zhang Xue , Zhang Peiyuan , Ying Hao , Jin Zi-Bing , Hu Guohong 
Published: February 2022

Significance
Breast cancer is a major threat of women’s health worldwide. Nontumor cell components play crucial roles in cancer. Macrophages, the cells of the innate immune system that normally exert antitumor activities, can be educated by tumors to an alternatively activated phenotype that is known to promote tumor progression. Understanding the mechanism of macrophage education by tumor cells will help the design of new therapeutic approaches. We find that breast tumor cells induce the expression of a microRNA, miR-182, in macrophages, and miR-182 promotes macrophage alternative activation to drive tumor development. Importantly, using cationized mannan-modified extracellular vesicles to load miR-182 inhibitors and deliver the inhibitors specifically into macrophages can effectively inhibit alternative activation of macrophages and suppress breast tumor development.
EURAMET Key Comparison EURAMET.M.D-K4.2020: Hydrometer calibration comparison from 600 kg/m3 to 2000 kg/m3
Authors: Malengo Andrea , Eppers Daniela , Akcadag Umit Y , Furtado Andreia , Schiebl Markus , Vamossy Csilla , Bebic Jelena , Milutinovic Milan , Jintao Wang 
Published: February 2022

Main text
This report presents the results of the key comparison EURAMET.M.D-K4.2020 (EURAMET 1496) that covered the calibration of high-resolution hydrometers for liquid in the density range 600 kg/m3 to 2000 kg/m3 at the reference temperature of 20 oC. Nine laboratories participated in this key comparison, eight European national metrology institutes and one from Asia Pacific metrology: NIM from China. The participating laboratories were initially divided into two petals linked by two density laboratories: INRIM and PTB. In each petal, four similar transfer standards, hydrometers in the density range 600 kg/m3 to 2000 kg/m3 are used.
The equipment used by the participants was found to have very similar characteristics. Most of the declared relative uncertainties were within the 5x10-5.
The results of all participated laboratories have been linked to the CIPM key comparison CCM.D-K4 by INRIM and PTB. Discrepant results have been reported for three laboratories, which, however, do not affect their CMCs.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
SIM.M.P-S8 final report
Authors: Espinoza M , Flores A , Vega N , Baez R 
Published: February 2022

Main text
This report shows the final results of the bilateral comparison SIM.M.P-S8 between the Custodian Laboratory of National Pressure Standards of Chile, LCPN-P (with the National Aeronautics Company - ENAER) and the National Institute of Technology, Standardization and Metrology, INTN of Paraguay, in the field of hydraulic pressure up to 70 MPa. The comparison was carried out between December 2011 and May 2012. Each laboratory used a pressure balance as a reference standard covering the range from 7 MPa to 70 MPa for the comparison. The transfer standard for the comparison was a digital manometer OMEGA, PCL-3000-4 with an accuracy of 0.05 % of full scale and a resolution of 0.01 MPa.
The pilot laboratory, LCPN-P, provided the transfer standard and made the analysis of the results, while the reference value was provided by INTN Paraguay.
An analysis of compatibility between the results of the present bilateral comparison and the supplementary comparison SIM.M.P-S7 was made, obtaining satisfactory results, which enables a link between both comparisons.
To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database https://www.bipm.org/kcdb/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Material classification based on Dual-Energy Micro-CT images by the Gaussian mixture model.
Authors: Mami-Zadeh H. , Solgi R. , Carrier J.-F. , Ghadiri H. 
Published: February 2022

Abstract
This study aimed to implement an unsupervised classification
method through the Gaussian mixture model to classify different
materials using the scatter diagram of the linear attenuation
coefficients acquired from dual-energy micro-CT imaging. This method
estimates each cluster's distribution parameters and performs
classification based on the posterior probability with a
pre-determined cluster number. Our studies on dual-energy images of
a phantom showed that the distribution of linear attenuation
coefficient of different materials on the scatter diagram has a
Gaussian distribution, and clusters can be classified using
model-based clustering. The result of this classification method is
related to the actual materials in the phantom, where a specific
cluster represents each material. This classification method can be
potentially used when the clusters are overlapped and the material
is separated with high accuracy.
Effectiveness of the Bacillus subtilis genome-reduced strain as an ethanol production host
Authors: Grinanda Dita , Hirasawa Takashi 
Published: February 2022

ABSTRACT
We investigated the performance of a genome-reduced strain of Bacillus subtilis MGB874, whose 0.87 Mbp of genomic DNA was cumulatively deleted, as an ethanol production host. A recombinant strain A267_EtOH was constructed by introducing the pdc and adhB genes from Zymomonas mobilis, both of which were expressed from an isopropyl-β-d-1-thiogalactopyranoside-inducible spac promoter, into the A267 strain, a tryptophan prototrophic derivative of the MGB874 with disruption of metabolic pathways for producing lactic acid, acetic acid, and acetoin. Focusing on the stationary phase in fed-batch fermentation, 1.6 g L−1 ethanol was produced by the A267_EtOH strain after 144 h. Moreover, its ethanol production further increased by approximately 3.7-fold (5.9 g L−1) at 80 h through replacing the spac promoter for expressing pdc and adhB genes with the lytR promoter and the yield was about 112%. These results indicate that the MGB874 is an effective host for ethanol production during the stationary phase.
Improving protein–ligand docking and screening accuracies by incorporating a scoring function correction term
Authors: Zheng Liangzhen , Meng Jintao , Jiang Kai , Lan Haidong , Wang Zechen , Lin Mingzhi , Li Weifeng , Guo Hongwei , Wei Yanjie , Mu Yuguang 
Published: February 2022

Abstract
Scoring functions are important components in molecular docking for structure-based drug discovery. Traditional scoring functions, generally empirical- or force field-based, are robust and have proven to be useful for identifying hits and lead optimizations. Although multiple highly accurate deep learning- or machine learning-based scoring functions have been developed, their direct applications for docking and screening are limited. We describe a novel strategy to develop a reliable protein–ligand scoring function by augmenting the traditional scoring function Vina score using a correction term (OnionNet-SFCT). The correction term is developed based on an AdaBoost random forest model, utilizing multiple layers of contacts formed between protein residues and ligand atoms. In addition to the Vina score, the model considerably enhances the AutoDock Vina prediction abilities for docking and screening tasks based on different benchmarks (such as cross-docking dataset, CASF-2016, DUD-E and DUD-AD). Furthermore, our model could be combined with multiple docking applications to increase pose selection accuracies and screening abilities, indicating its wide usage for structure-based drug discoveries. Furthermore, in a reverse practice, the combined scoring strategy successfully identified multiple known receptors of a plant hormone. To summarize, the results show that the combination of data-driven model (OnionNet-SFCT) and empirical scoring function (Vina score) is a good scoring strategy that could be useful for structure-based drug discoveries and potentially target fishing in future.
The DOMINO web-server for active module identification analysis
Authors: Levi Hagai , Rahmanian Nima , Elkon Ran , Shamir Ron 
Published: February 2022

AbstractMotivationActive module identification (AMI) is an essential step in many omics analyses. Such algorithms receive a gene network and a gene activity profile as input and report subnetworks that show significant over-representation of accrued activity signal (‘active modules’). Such modules can point out key molecular processes in the analyzed biological conditions.ResultsWe recently introduced a novel AMI algorithm called DOMINO and demonstrated that it detects active modules that capture biological signals with markedly improved rate of empirical validation. Here, we provide an online server that executes DOMINO, making it more accessible and user-friendly. To help the interpretation of solutions, the server provides GO enrichment analysis, module visualizations and accessible output formats for customized downstream analysis. It also enables running DOMINO with various gene identifiers of different organisms.Availability and implementationThe server is available at http://domino.cs.tau.ac.il. Its codebase is available at https://github.com/Shamir-Lab.