bluuebunny/crossref_metadata_2025_split huggingface dataset:
Employment as HIV Prevention: An Employment Support Intervention for Adolescent Men Who Have Sex With Men and Adolescent Transgender Women of Color
Authors: Hill Brandon J. , Motley Darnell N. , Rosentel Kris , VandeVusse Alicia , Fuller Charlie , Bowers Shannon M.E. , Williams Meghan , Kipke Michele , Kuhns Lisa , Pashka Nicole , Reisner Sari , DeMonte Justin B. , Goolsby Rachel W. , Rupp Betty M. , Slye Nicole , Strader Lisa C. , Schneider John A. , Razzano Lisa , Garofalo Robert 
Published: May 2022

Background:
The purpose of this study was to adapt and pilot-test an employment support, primary HIV intervention tailored to the needs of adolescent men who have sex with men and adolescent transgender women of color.

Setting:
The intervention was implemented in 2 settings: controlled environment (Phase 1) and real-world community-based (Phase 2) setting in Chicago, IL.

Methods:
Eighty-seven adolescent men who have sex with men and adolescent transgender women of color ages 16–24 participated in Work2Prevent, a 4-session employment and HIV prevention intervention, designed to increase job-readiness and reduce HIV risk. Intervention sessions consisted of group activities: educational games, roleplaying/modeling behavior, and self-regulation exercises. Participants were assessed at baseline, postintervention, and 8-month (Phase 1) or 3-month follow-up (Phase 2).

Results:
Participants evaluated Work2Prevent as feasible and acceptable, rating intervention quality, usefulness, and satisfaction highly. Overall, 59.6% (Phase 1) and 85.0% (Phase 2) participants attended 2 or more sessions. At 8 months, Phase 1 participants reported a mean increase of 11.4 hours worked per week. Phase 2 participants reported a mean increase of 5.2 hours worked per week and an increase in job-seeking self-efficacy. Phase 2 participants also reported a decrease in transactional sex work.

Conclusion:

Work2Prevent is one of the first structural primary HIV interventions to specifically focus on adolescent employment readiness. Findings suggest Work2Prevent is feasible and acceptable, improved adolescent employment outcomes, and reduced HIV risk associated with transactional sex work. Our study underscores the need for alternative pathways, such as addressing socioeconomic determinants, to prevent adolescent HIV infection.
The Aortic Ductus Diverticulum—Innocent Bystander or Potential Source of Thromboembolic Stroke?
Authors: Celik Erkan , Goertz Lukas , Nelles Christian , Hammes Jochen , Achenbach Tobias , Kabbasch Christoph , Persigehl Thorsten , Maintz David , Bunck Alexander Christian 
Published: May 2022

Objective
Due to reversal blood flow in the diastolic phase, outpouchings at the aortic isthmus may carry the risk of thrombus formation and subsequent thromboembolism. The objective was to evaluate the association between aortic ductus diverticula (ADDs) and ischemic brain alterations in cerebral magnetic resonance imaging.

Methods
A retrospective analysis of 218 patients who received both a dedicated computed tomography angiography of the thoracic aorta and a brain magnetic resonance imaging was performed. Two radiologists independently reviewed all examinations for the presence of ADD as well as ischemic alterations of the brain. The association between this anatomical variant and ischemic brain alterations was evaluated by univariate and bivariate logistic regression analyses.

Results
ADDs were identified/present in 35 of 218 patients (16%). Ischemic brain alterations were found in 57% of patients (20/35) with an ADD and in 42% of the control group (77/183, P = 0.1). The presence of an ADD did not prove to be an independent risk factor for ischemic brain alterations after multivariate adjustment (odds ratio = 1.7, 95% confidence interval = 0.72–3.96, P = 0.225).

Conclusions
In the present study, ADDs were not significantly associated with ischemic brain alterations. Therefore, ADDs seem to be an innocent bystander with respect to the pathogenesis of ischemic brain alterations.
Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression
Authors: Wang Zhen , Liu Deng , Yan Qi , Liu Fang , Zhan Mengting , Qi Shunli , Fang Qi , Yao Lei , Wang Weizhi , Zhang Ruixin , Du Jian , Chen Lijian 
Published: May 2022

Background.
Hepatic ischemia-reperfusion (I/R) injury is the main factor affecting the morbidity and mortality associated with perioperative complications of liver transplantation and major hepatectomy. AXL is a member of the TYRO3, AXL, MERTK family and is involved in immune and apoptosis processes in multiple organs. However, the role of AXL in hepatic I/R injury remains to be elucidated.

Methods.
Mice pretreated with rmGas6 or R428 and mice tail vein injected with adeno-associated virus knockdown suppressor of cytokine signaling protein-1 (SOCS-1) underwent liver I/R surgery to detect the function of activated AXL in vivo. Primary hepatocytes undergo hypoxic reoxygenation injury in vitro.

Results.
AXL expression was significantly upregulated, and phosphorylated-AXL was substantially downregulated in liver transplantation patients and hepatic I/R surgery mice. A mouse model of hepatic I/R injury showed that AXL activation reduced liver inflammation and liver cells apoptosis. The inhibition of AXL activation (AXL-specific inhibitor R428) aggravated hepatic I/R injury, resulted in larger areas of liver injury, aggravated inflammatory response, and increased apoptosis of liver cells. In addition, activated AXL promotes the expression level of SOCS-1 and inhibits toll-like receptor 4 and its downstream signaling pathways. Finally, SOCS-1 was knocked down with an adeno-associated virus, and activated AXL failed to protect against hepatic I/R injury.

Conclusions.
AXL activation protects the liver from I/R injury by upregulating SOCS-1 and inhibiting the toll-like receptor 4/myeloid differentiation factor-88/nuclear factor kappa-B signaling axis. Targeting AXL may be a new therapeutic option for ameliorating hepatic I/R injury.
High Oxygenation During Normothermic Regional Perfusion After Circulatory Death Is Beneficial on Donor Cardiac Function in a Porcine Model
Authors: Moeslund Niels , Long Zhang Zhang , Bo Ilkjaer Lars , Ryhammer Pia , Cramer Christine , Palmfeldt Johan , Pedersen Michael , Erasmus Michiel Elardus , Tsui Steven , Eiskjaer Hans 
Published: May 2022

Background.
Thoracoabdominal normothermic regional perfusion (NRP) is a new method for in situ reperfusion and reanimation of potential donor organs in donation after circulatory death by reperfusion of the thoracic and abdominal organs with oxygenated blood. We investigated effects of high oxygenation (HOX) versus low oxygenation (LOX) during NRP on donor heart function in a porcine model.

Methods.
Pigs (80 kg) underwent a 15-min anoxic cardiac arrest followed by cardiac reanimation on NRP using a heart-lung bypass machine with subsequent assessment 180 min post-NRP. The animals were randomized to HOX (FiO2 1.0) or LOX (FiO2 0.21 increased to 0.40 during NRP). Hemodynamic data were obtained by invasive blood pressure and biventricular pressure-volume measurements. Blood gases, biomarkers of inflammation, and oxidative stress were measured.

Results.
Eight of 9 animals in the HOX group and 7 of 10 in the LOX group were successfully weaned from NRP. Right ventricular end-systole elastance was significantly improved in the HOX group compared with the LOX group, whereas left ventricular end-systole elastance was preserved at baseline levels. Post-NRP cardiac output, mean arterial, central venous, and pulmonary capillary wedge pressure were all comparable to baseline. Creatinine kinase-MB increased more in the LOX group than the HOX group, whereas proinflammatory cytokines increased more in the HOX group than the LOX group. No difference was found in oxidative stress between groups.

Conclusions.
All hearts weaned from NRP showed acceptable hemodynamic function for transplantation. Hearts exposed to LOX showed more myocardial damage and showed poorer contractile performance than hearts reperfused with high oxygen.
Enhanced Humoral Immune Response After COVID-19 Vaccination in Elderly Kidney Transplant Recipients on Everolimus Versus Mycophenolate Mofetil–containing Immunosuppressive Regimens
Authors: de Boer Silke E. , Berger Stefan P. , van Leer–Buter Coretta C. , Kroesen Bart-Jan , van Baarle Debbie , Sanders Jan-Stephan F. ,   on behalf of the OPTIMIZE study group
Published: May 2022

Background.
Elderly kidney transplant recipients (KTRs) represent almost one third of the total kidney transplant population. These patients have a very high coronavirus disease 2019 (COVID-19)–related mortality, whereas their response to COVID-19 vaccination is impaired. Finding ways to improve the COVID-19 vaccination response in this vulnerable population is of uttermost importance.

Methods.
In the OPTIMIZE trial, we randomly assign elderly KTRs to an immunosuppressive regimen with standard-exposure calcineurin inhibitor (CNI), mycophenolate mofetil, and prednisolone or an adapted regimen with low dose CNI, everolimus, and prednisolone. In this substudy, we measured the humoral response after 2 (N = 32) and 3 (N = 22) COVID-19 mRNA vaccinations and the cellular response (N = 15) after 2 vaccinations.

Results.
. The seroconversion rates of elderly KTRs on a standard immunosuppressive regimen were only 13% and 38% after 2 and 3 vaccinations, respectively, whereas the response rates of KTRs on the everolimus regimen were significantly higher at 56% (P = 0.009) and 100% (P = 0.006). Levels of severe acute respiratory syndrome coronaVirus 2 IgG antibodies were significantly higher at both time points in the everolimus group (P = 0.004 and P < 0.001). There were no differences in cellular response after vaccination.

Conclusions.
An immunosuppressive regimen without mycophenolate mofetil, a lower CNI dose, and usage of everolimus is associated with a higher humoral response rate after COVID-19 vaccination in elderly KTRs after transplantation. This encouraging finding should be investigated in larger cohorts, including transplant recipients of all ages.
Marinomonas lutimaris sp. nov., isolated from a tidal flat sediment of the East China Sea
Authors: Gao Yuxin , Wei Yuli , Wang Peng 
Published: May 2022

A Gram-stain-negative bacterial strain, designated as E165T, was isolated from a tidal flat sediment of the East China Sea. Strain E165T grew optimally at pH 6, at 32 °C and with 1–2 % (w/v) NaCl. The 16S rRNA gene sequence similarity results revealed that strain E165T was most closely related to

Marinomonas rhizomae

IVIA-Po-145T,

Marinomonas polaris

CK13T,

Marinomonas foliarum

IVIA-Po-155T,

Marinomonas hwangdonensis

HDW-15T,

Marinomonas pontica

46-16T,

Marinomonas mangrovi

B20-1T and

Marinomonas shanghaiensis

DSL-35T with values of 97.0–98.5 %. The digital DNA–DNA hybridization and average nucleotide identity values between strain E165T and the reference strains were 21.9–34.3 % and 77.6–87.3 %, respectively. The DNA G+C content of the isolate was 42.9 mol%. Strain E165T contained Q-8 as the sole ubiquinone and C16 : 0, summed feature 8 (C18 : 1
ω7c and/or C18 : 1
ω6c) and summed feature 3 (C16 : 1
ω7c and/or C16 : 1
ω6c) as the major fatty acids. The major polar lipids of strain E165T were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, aminolipid and aminophospholipid. On the basis of phenotypic characteristics, phylogenetic analysis and DNA–DNA relatedness, a novel species, Marinomonas lutimaris sp. nov., is proposed with E165T (=MCCC 1K06241T=KCTC 82809T) as the type strain.
Internationalization of Chinese open universities
Authors: Hou Songyan 
Published: May 2022

PurposeIn 2019, the goal of developing a world-class open university through different stages was put forward by the Open University of China (OUC), which indicated that internationalization for Chinese open universities came to the agenda. However, international activities of open universities are different from those in conventional universities, and how to fulfill the goal of internationalization is a main issue faced by educators in Chinese open and distance education arena. This research aimed to identify ways of internationalization for the OUC system.Design/methodology/approachA survey was employed as a tool to get feedback from target audience. A questionnaire was released to academics, management staff and researchers to the 44 provincial open universities. A total of 501 samples were collected. Among them, 332 were from academics, which accounted for 66.27%, 152 were from school-level directors and 17 were from university-level leaders.FindingsBy analyzing the data collected in the survey, the study proposes four recommendations to fulfill the goal of internationalization for Chinese open universities and these include strengthening top-level strategies, building up professional teams, sharing learning resources and delivering upper-level programs.Research limitations/implicationsThe targets of this research were all staff at different levels in the central and local institutions; no students were included in the research. Therefore, this did not reflect a picture from the student perspective, and this will be improved in future research.Originality/valueSince the establishment of the OUC in 1979, there has been no clear and systematic pathways for the development of internationalization of Chinese open universities. This research proposes a theoretical framework of internationalization for open universities and suggests a direction for future development.
A vision-aided fuzzy adaptive sliding mode controller for autonomous landing of a nonlinear model helicopter on a moving marine platform
Authors: Pakro Farhad , Nikkhah Amir Ali 
Published: May 2022

PurposeA vision-assisted fuzzy adaptive sliding mode controller is presented in this research and implemented on a nonlinear helicopter model, which is about to land on a moving ship. Stabilization of the dynamics and tracking the landing path are required, at the same time. This study aims to take one step closer to fully autonomous landing, which is a growing trend.Design/methodology/approachAn integrated guidance and control is considered for the model helicopter. A fuzzy logic is designed to adaptively choose the best control parameters for the sliding mode controller and solve the challenge of parameter tuning. A self-organizing matrix consisting of fuzzy sliding mode parameters is formed instead of a single parameter with the goal of enhancing controller tracking capability. A simple, precise and fast image recognition system based on OpenCV is used to detect the proper point for descending without getting any special data from the ship and by only using a general “H” sign.FindingsThe problem is simulated under intense disturbances, while the approach and landing performances are acceptable. Controller performance is compared and validated. Simulation results show the robustness, agility, stability and outperformance of the proposed controller.Originality/valueThe novelty of this paper is the designed procedure for using a simple image recognition system in the process of autonomous ship-landing, which does not use any special data sent from the ship. Besides, an improved nonlinear controller is designed for integrated guidance and control in this specific application.
Online community development in the early stages: the life cycle model application to Medical Sciences Stack Exchange
Authors: Fu Hengyi , Oh Sanghee 
Published: May 2022

PurposeThis study aims to investigate the nature and evolution of online communities in the early stages of their life cycles. The authors analyze the topics of discussions in an online community to identify issues related to community development. The authors also compare the topics of exemplary questions that founding members believed to be asked with the real questions based on members' information needs.Design/methodology/approachThe authors use Medical Sciences Stack Exchange, a health Q&A community of Stack Exchange, which requires four stages of development: definition, commitment, private beta and public beta. The authors collect postings of discussions and health questions in the first three stages, perform a content analysis of the postings and analyze the topics of discussions and health questions.FindingsThe authors find that the topics of discussions evolved dynamically with the issues of community governance, role as a medical/health community, members and roles, content management, quality control and community design. The authors also find that the real questions included more specific and diverse issues than the exemplary questions that founding members expected.Originality/valueTheoretically, this study tests the community life cycle model in an online community that has explicit phase markers. The findings could shed light on community development and help prioritize issues to solve and decisions to make in its early stages. Additionally, this study focuses on the challenges and concerns in online health community building and solutions generated by collective efforts that could influence health communications in online communities.
How to make it stick? Institutionalising process improvement initiatives
Authors: Abeygunasekera Ahangama Withanage Janitha Chandimali , Bandara Wasana , Wynn Moe Thandar , Yigitbasioglu Ogan 
Published: May 2022

PurposeUnderstanding how organisations can institutionalise the outcomes of process improvement initiatives is limited. This paper explores how process changes resulting from improvement initiatives are adhered to, so that the changed processes become the new “norm” and people do not revert to old practices. This study proposes an institutionalisation process for process improvement initiatives.Design/methodology/approachFirstly, a literature review identified Tolbert and Zucker’s (1996) institutionalisation framework as a suitable conceptual framework on which to base the enquiry. The second phase (the focus of this paper) applied the findings from two case studies to adapt this framework (its stages and related factors) to fit process improvement contexts.FindingsThe paper presents an empirically and theoretically supported novel institutionalisation process for process improvement initiatives. The three stages of the institutionalisation process presented by Tolbert and Zucker (1996) have been respecified into four stages, explaining how process changes are institutionalised through “Planning”, “Implementation”, “Objectification” and “Sedimentation” (the original first stage, i.e. “Habitualisation” being divided into Planning and Implementation). Some newly identified Business Process Management (BPM) specific factors influencing the institutionalisation processes are also discussed and triangulated with the BPM literature.Research limitations/implicationsThe study contributes to the BPM literature by conceptualising and theorising the stages of institutionalisation of process improvement initiatives. In doing so, the study explicitly identifies and considers several key contextual factors that drive the stages of institutionalisation. Practitioners can use this to better manage process change and future researchers can use this framework to operationalise institutionalisation of process change.Originality/valueThis is the first research study that provides an empirically supported and clearly conceptualised understanding of the stages of institutionalising process improvement outcomes.
Geodesign and Sustainable Development Goals in the environmental parameterization of the Iron Quadrangle region, Brazil: an academic experience
Authors: Moura Ana Clara Mourão , Morais Camila Fernandes de , Gonçalves Mello Tiago Augusto 
Published: May 2022

PurposeThere are countless challenges concerning the process of interest mediation. Regarding territorial planning, the participation of different stakeholders is essential. In this sense, Geodesign is a method that supports decision-making based on geocollaboration and co-creation, using geospatial data and tools. The purpose of this study was to use the method to support the co-creation of environmental projects and policies climate-oriented for the Iron Quadrangle region, Brazil.Design/methodology/approachThe Brazilian platform of Geodesign, GISColab, was used to support the activity. The experiment involved undergraduate and graduate students in Urban Planning and in Geography and technicians that work with planning subjects. Social isolation measures imposed by the pandemic resulted in an adaptation of the dynamic, which was held entirely online.FindingsThe study group proposed 28 designs, in which the most discussed topics were landscape (43%), climate (25%) and risk (25%). This may be associated with the fact that the workshop was conducted in consideration of the UN's Sustainable Development Goals (SDGs) and the environmental crisis, but it might also suggest the group’s prior concern with such issues. Other SDGs were contemplated, with the productive sector as the most negatively impacted by proposals. This situation reinforces the importance of incorporating different actors (a term used for participants in the Geodesign method, referring to representatives from groups of the society) into planning processes. Geodesign was easily accepted and assimilated by participants.Originality/valueThe proposed methodology proved to be positive for this type of study and GISColab, the Brazilian Geodesign platform, was easily adapted to the characteristics and demands of the experience.
Green supply chain management and SMEs environmental performance: green HRM practices as antecedent from service sector of emerging economy
Authors: Aldaas Raghad , Mohamed Rosmah , Hareeza Ali Mass , Ismail Noor Azlin 
Published: May 2022

PurposeThe research aimed to study the influence of green human resources management practices (GHRMPs) on green supply chain management (GSCM) and environmental performance while examining how those green practices affect environmental performance.Design/methodology/approachThe study investigated 314 cases (responses) from the small and medium-sized enterprises belonging to the service sector from an emergent economy (i.e. Oman). The study model was developed based on the theory of resource-based view and the theory of ability, motivation and opportunity. The structural equation modeling was used for hypotheses testing using SmartPLS 3 software.FindingsBased on the findings, green hiring and green training and innovation have a positive and significant effect on GSCM, while both of them have no effect on environmental performance. Further, green performance management and compensation positively influenced the environmental performance but not GSCM. Furthermore, GSCM significantly and positively influenced environmental performance.Originality/valueGHRMPs and GSCM can enhance environmental performance. Organizations should consider this interesting finding if they aim to reduce their negative environmental effect, conserve energy, prevent pollution and recycle garbage. Despite the fact that the present environment-friendly culture is still in its infancy, it adds uniqueness to this research by investigating the phenomenon's importance.