bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non–regular McKean–Vlasov equations and calibration problem in local stochastic volatility models
Authors: Djete Mao Fabrice 
Published: August 2022

Abstract
In order to deal with the question of the existence of a calibrated local stochastic volatility model in finance, we investigate a class of McKean–Vlasov equations where a minimal continuity assumption is imposed on the coefficients. Namely, the drift coefficient and, in particular, the volatility coefficient are not necessarily continuous in the measure variable for the Wasserstein topology. In this paper, we provide an existence result and show an approximation by N –particle system or propagation of chaos for this type of McKean–Vlasov equations. As a direct result, we are able to deduce the existence of a calibrated local stochastic volatility model for an appropriate choice of stochastic volatility parameters. The associated propagation of chaos result is also proved.
Efficacy and safety of irinotecan drug-eluting CalliSpheres beads in treating unresectable gastrointestinal cancer liver metastases
Authors: Bi Yonghua , Guo Kefeng , Jiao Dechao , Wang Yang , Su Mengdan , Ren Jianzhuang , Han Xinwei 
Published: August 2022

Abstract
Background
Drug eluting beads transarterial chemoembolization (DEB-TACE) is considered as an effective and safe method in treating hepatocellular carcinoma. CalliSpheres beads (CB) is a novel microsphere product in China. Currently, few studies reported efficacy and safety of DEB-TACE with irinotecan-eluting CB in treating unresectable gastrointestinal cancer liver metastases (GRLM). This study aimed to evaluate the clinical outcomes of DEB-TACE with irinotecan-eluting CB in treating unresectable GRLM.
Methods
From May 2016 to May 2022, 28 patients with unresectable GRLM who were treated with DEB-TACE with irinotecan-eluting CB procedures were studied. Objective response rate (ORR) and disease control rate (DCR) were primary endpoints, Overall survival and progression-free survival (PFS) were the minor endpoints. Other indexes such as Child-Pugh class, systemic treatments and adverse events were assessed before or after procedure.
Results
ORR and DCR were 18.2% and 86.4%, respectively, at 1 month; were 27.8% and 61.1%, respectively, at 3 months; then were 21.4% and 50.0%, respectively at 6 months. As for survival profiles, 1-year overall survival was 70.0%; 3-year overall survival was 37.5%; the median overall survival and PFS were 15.2 months and 5.2 months, respectively. No severe adverse events were observed during and after DEB-TACE. The most common complication was abdominal pain (n = 13). Besides, nausea, fever, vomiting were observed in 5, 4 and 5 patients, respectively.
Conclusions
DEB-TACE with irinotecan-eluting CB is effective and safe, with good tolerance in treating unresectable GRLM.
Effect of loading rate on transient response of a nano scale medium based on continuum and thermal conduction nonlocal model
Authors: mirparizi mina , Zhang Chunwei 
Published: August 2022

AbstractThermoelastic study at nano scale is an important matter along with the minimizing of the systems and intensive use of ultrafast lasers that size can influence on elastic deformation and thermal conduction grow. In this study, thermal and mechanical responses of nano-scaled body, exposed to thermal loads from outer supply and environment is inquired. In this research, nonlocal thermoelasticity model according to both nonlocal thermal conduction law and continuum theory is represented. A nonlinear finite element equation is applied to solve the coupled governing equations. It is considered that a nano scale medium is subjected to a sudden thermal shock. The results reveal some interesting aspects of wave propagation. The effects of thermal loading and loading rate on the wave propagation are discussed. The impact of the thermal and elastic nonlocality on wave dissemination is also shown graphically and discussed. Comparing the wave propagation characteristics of the classical and generalized thermoelasticity theories in the nonlocal models shows the superiorities of the proposed model. The maximum compressive stress may be observed at the wave front due to the resistance of the particles that are located ahead of the stress wave.
Title High fat-induced upregulation of LOX-1 expression in RF/6A cells with high glucose
Authors: Li Qin , Zhang Mingmei , Gao Qianying , Chen Xueyi 
Published: August 2022

Abstract
AIM: To investigate the effect of oxidized low-density lipoprotein (ox-LDL) on the expression of lectin-like receptor of ox-LDL (LOX-1) and intercellular adhesion molecule-1 (ICAM-1) in the monkey choroid-retinal endothelial cell line RF/6A under high-glucose conditions. METHODS:RF/6A cells were grown in normal or high-glucose (25 mM) medium for 2 days. In parallel, RF/6A cells were grown in medium with high glucose and ox-LDL (25 or 50 μg/ml) or normal medium with ox-LDL (50 or 75 μg/ml), the concentrations of which were determined by initial screening based on migration and immunofluorescence. LOX-1 and ICAM-1 expression was determined by western blot analysis. The maximal effect on RF/6A cells was observed with a concentration of 25 mmol/l glucose and incubation for 48 h. Based on the immunofluorescence assay, the expression of LOX-1 was upregulated under high glucose compared with that under normal glucose and more pronounced with a glucose concentration of 50 μg/ml. Western blot indicated significant LOX-1 overexpression and blocked ICAM-1 activation under high-glucose conditions with or without ox-LDL in RF/6A cells.RESULTS: In the normal glucose+ox-LDL group (50 and 75 μg), LOX-1 expression increased as compared with that in the control group (P<0.01 and P<0.05, respectively). In the high glucose group (25 and 50 μg), expression of LOX-1 and ICAM-1 increased as compared with that in the control group (P>0.05 and P>0.01, respectively). CONCLUSION:These findings indicated that a certain concentration of ox-LDL blocks high-glucose-induced retinal vascular endothelial injury by inhibiting the upregulation of ICAM-1 expression due to a high-glucose environment. Thus, dyslipidemia may play an important role in the development of diabetic retinopathy, emphasizing the importance of active regulation of blood lipids in diabetic retinopathy therapy.
Surgical treatment of pancreatic metastases: a clinicopathologic study of 43 patients
Authors: Seki Makoto , Saiura Akio , Takahashi Yu , Inoue Yosuke , Katori Masamichi , Yamamoto Noriko , Takamatsu Manabu , Kato Yo 
Published: August 2022

Abstract
Purpose It is rare to find surgically-resectable metastatic lesions that are limited to the pancreas, by preoperative imaging. In this retrospective study, we reviewed the histopathologic findings in pancreatic surgical resection specimens to determine the factors that contribute to the prognostic improvement of surgical treatment for pancreatic metastases. Methods From 1979 to 2018, 43 patients underwent pancreatic resection for metastatic tumors in the Department of Hepato-Biliary-Pancreatic Surgery of the Cancer Institute of the Japanese Foundation for Cancer Research. Survival curves were created using the Kaplan–Meier method, and comparisons of survival were performed using the log-rank test.Results Primary tumors comprised renal cell carcinoma (RCC), colorectal carcinoma (CRC), and miscellaneous malignancies (MM) in 23, 9, and 11 cases, respectively. Histopathologically, the patterns of metastases were classified as hematogenous (32), lymphatic (8), and peritoneal (3). Regarding the prognosis after metastasectomy of the pancreas, there were significant differences for disease-free interval (< 5 years versus ≥5 years) and primary tumor (RCC versus CRC/MM). The rate of secondary or accompanying lymph node metastasis around the main metastasis was 5/9 (56%) for CRC, 5/11 (45%) for MM, and 1/23 (4%) for RCC. Conclusion Survival outcomes are more favorable for disease-free intervals ≥ 5 years, pancreatic metastasis from RCC, and with lymphatic metastasis. Lymph node dissection is not strictly necessary for the surgical removal of pancreatic metastasis from RCC, whereas this is highly recommended for patients with metastasis from CRC or MM.
Spanish version of the ICIQ-Bowel questionnaire among colorectal cancer patients: Construct and criterion validity
Authors: Sacomori Cinara , Lorca Luz Alejandra , Martinez-Mardones Mónica , Pizarro-Hinojosa Marta Natalia , Rebolledo-Diaz Gonzalo Sebastián , Vivallos-González Jessica Andrea 
Published: August 2022

AbstractBowel complaints are very common among patients with colorectal cancer. This study aimed to examine construct and criterion validity, as well as internal consistency, of the Chilean Version of the International Consultation on Incontinence Questionnaire Bowel Module (ICIQ-B) among people with colorectal cancer. Cross-sectional, validation study performed with 106 colorectal cancer patients from Hospital del Salvador, Chile. Bowel function was assessed with the ICIQ-B. Specific items of a quality-of-life questionnaire (EORTC QLQ-CR29) were used to correlate with similar ICIQ-B items for criterion validity. Construct validity was assessed with exploratory factor analysis and hypothesis testing. For internal consistency, Cronbach’s alpha was computed. The exploratory factor analysis resulted in three factors that accounted for 74.26% of the total variance: bowel control (59.69%), bowel pattern (7.98%) and quality of life (6.59%). Rectal cancer patients showed worse bowel pattern (p = 0.001), bowel control (p = 0.001) and quality of life (p < 0.001) scores compared to colon cancer patients. There was no significant difference between men and women regarding bowel function. Regarding criterion validity, the ICIQ-B items showed a significant correlation with similar QLQ-CR29 items. Considering that this questionnaire appraises bowel function in more depth, it is recommended for use in clinical practice and research with colorectal cancer patients.
Primary Colorectal Diffuse Large B-cell Lymphoma: a Report of Eighteen Cases in a Tertiary Care Center
Authors: Vasconcelos Flavia C , Araujo Rodrigo Otavio Castro , Bernardo Paula Sabbo , Hancio Thaís , de Moraes Gabriela Nestal , Bigni Ricardo Sá , Valadão Marcus , Pinto Luciana Wernersbach , Maia Raquel Ciuvalschi 
Published: August 2022

Abstract
Primary colorectal diffuse large B-cell lymphoma (DLBCL) is very rare colon malignancy. Due to a possible delay in the diagnosis, it is important to know the main demographic and clinical characteristics of these patients. Retrospective analysis of 18 patients diagnosed with primary colorectal DLBCL during a 17-year period at the tertiary National Cancer Institute of Brazil (INCA) hospital. Demographic characteristics, tumor localization, HIV status, lactate dehydrogenase (LDH) levels, treatment modality and follow-up status were obtained from medical records. Survival was estimated from the date of diagnosis until death. There were 11 male and seven female patients in our cohort, the median age at diagnosis was 59.5 years and four patients were HIV positive. Tumor was mainly localized in the right proximal colon. Patients were treated with chemotherapy (CT) and/or surgical resection. Eleven patients died during a median follow-up of 59 months and the median survival time was 10 months for the whole group. Six or more cycles of CT (HR = 0.19; CI 95% 0.054–0.660, p = 0.009), low LDH levels (HR = 0.229; CI 95% 0.060–0.876, p = 0.031) and surgical resection (HR = 0.23; CI 95% 0.065–0.828, p = 0.030) were associated with reduced risk of death in univariate analysis. DLBCL affected more frequently middle-aged man and was primarily located in the right colon. These observations should be considered for differential diagnosis. Six cycles of CT, low LDH levels and surgical resection were associated with better survival. Our results are consistent with previous publications and address the importance of correct colorectal DLBCL diagnosis and treatment.
World’s first record of infestation of Dactylopius ceylionicus (Green) (Hemiptera:Dactylopiidae) on Opuntia elatior Mill. (Cactaceae) from Central India
Authors: Talhande Darshan R. , Patil Suvarna P. 
Published: August 2022

Abstract
The attack of wild cochineal insect, Dactylopius ceylionicus (Green, 1869) (Hemiptera: Coccoideae : Dactylopiidae) has been reported for the first time on Red flower Prickly pear, Opuntia elatior Mill. (Cactaceae) from Central India. Voucher specimen of Insect sample was submitted to the National Bureau of Agricultural Insect Resources, Bangalore. Spatial distribution is localised to small region and has been shown on the map. Probable reasons for host diversification, evolution and possible economic benefits are discussed here and the need for further research has been emphasized.
Sensitivity, Specificity and Predictive Values of the Rapid Antigen Diagnosis Test of SARS-CoV-2 Virus Panbio COVID-19 at the Patient Screening Point of Hospital Geral De Luanda, Angola
Authors: de Lemos Santland , Silva Belchior da , Moreira Rosa , José Maria , Kapapelo Alexandre , Mayer Edson , Fila Angelina , Epaco Teresa , Ferreira Elma , Neves Yazalde das , Ramos Faustino , Manuel Kossi , Kagibanga Irene , Gago Edilson , Pocongo Barbara , Solari Paulo 
Published: August 2022

Abstract
Introduction: Alternative forms of diagnosis that are simpler than NAAT and with faster results (15–30 min) were developed based on the direct detection of SARS-CoV-2 viral proteins in nasal swabs and other respiratory tract secretions using a lateral flow immunoassay also called a rapid diagnostic test of antigen detection. The WHO recommends that these tests have at least a sensitivity of 80% and a specificity of 97% when compared to the reference test, the RT-PCR. We evaluated the performance of the rapid antigen detection test Panbio COVID-19 at a patient triage point at the Luanda General Hospital. Methods: A cross-sectional study of a prospective nature was carried out with the inclusion of 37 suspected symptomatic cases without a previous diagnosis of COVID-19. The database was created and processed in MedCal version 19.6. Sensitivity, specificity, positive and negative predictive value and accuracy are expressed in percentages with the respective 95% confidence intervals determined using a 2x2 table. Qualitative variables were presented in absolute and relative frequency. The McNemar's test was used to calculate the proportion of RAD test results Panbio COVID-19 in relation to the RT –PCR and a bilateral P value < 0.05 calculated based on the cumulative binomial distribution was considered significant. Results: In our study, 26 (70.3%) of the cases were male, and the mean age was 18 years, with a standard deviation of 14.8, with 14 (37.8%) residing in the municipality of Talatona. Regarding the days of evolution of symptoms, 34 (91.9%) had symptoms with one week of evolution. The RAD test Panbio COVID-19 had a sensitivity of 54.5% (CI 95% 23.3 – 83.2) and specificity of 96.1% (CI 95% 80.3 – 99.9). The positive and negative predictive value was 85.7% (95% CI 44.9 – 97.7) and 83.3% (95% CI 72.2– 90.5) respectively. The accuracy of the test was 83.7% (95% CI 67.9 – 93.8). The difference between the prevalence in the test Panbio COVID-19 and in RT-PCR it was 10.8% (95% CI -1.6 – 23.3), not being statistically significant (P=0.22). As for the cycle threshold, 71.4% of the samples that were positive for RAD test Panbio COVID-19 had a cycle threshold ≤ 25. Conclusion: The RAD test Panbio COVID-19 did not meet the minimum accuracy requirements recommended by the WHO. However, the predictive values were considerably high in symptomatic subjects.
A Comprehensive Study of Defects in Gallium Oxide by Density Functional Theory
Authors: JEWEL MOHI UDDIN , Hasan Samiul , Iftikhar  
Published: August 2022

Abstract
Ultrawide bandgap gallium oxide (Ga2O3) is a promising material for power semiconductor devices and deep ultraviolet (UV) solar-blind photodetectors. Understanding the properties of point defects in Ga2O3 is necessary to realize better-performing devices. A comprehensive study based on density functional theory (DFT), using the generalized gradient approximation (GGA): Perdew-Burke-Ernzerhof (PBE) exchange-correlation functional, of point defects in corundum (α), monoclinic (β), and orthorhombic (ε) phases of Ga2O3 is presented. The point defects include vacancies, interstitials, antisites, and extrinsic impurities in various phases of Ga2O3. Defect formation energies, charge transition energy levels, and defect concentrations variation with temperature are listed and presented under both gallium-rich (Ga-rich) and oxygen-rich (O-rich) growth conditions. The formation energy diagrams predict that the Ga2O3 phases favor the formation of Ga and O vacancies and the incorporation of extrinsic impurities. The calculations also show that the charge transition levels are deep inside the bandgap regardless of the Ga2O3 phase and growth environment. The impacts of temperature on the intrinsic point defects are analyzed by probing the vibrational modes of β-Ga2O3 thin films grown in a metal-organic chemical vapor deposition (MOCVD) system at 700 oC temperature and annealed at 1100 oC in an O-rich environment.
ANLN, COL8A1, MMP3, MMP14 and WNT5A, as potential diagnostic and therapeutic targets for early-stage colorectal cancer: evidence from integrated bioinformatics analysis
Authors: Tu Hengjia , Zhang Qingling , Xue Lingna 
Published: August 2022

Abstract
Colorectal cancer (CRC) is one of the most common cancers worldwide. Intense efforts have been made to elucidate the pathogeny, but the molecular mechanisms of early-stage CRC are still not well understood. This study aims to identify the candidate genes in the carcinogenesis of early-stage CRC Microarray datasets GSE44076, GSE41328 and GSE9348 were obtained from Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) were identified, and functional enrichment analyses were performed. The protein-protein interaction network (PPI) was constructed and the module analysis was performed by using STRING and Cytoscape. A total of 363 DEGs were identified, consisting of 48 downregulated genes and 315 upregulated genes. The enriched GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways of the DEGs mainly include collage catabolic process, extracellular matrix organization, skeleton system development and collagen fibril organization. 28 hub genes were identified, and biological process analysis revealed that these genes were mainly enriched in cell division, cell cycle, and nuclear division. Survival analysis showed that ANLN, COL8A1, MMP3, MMP14 and WNT5A may be related to the poor overall survival rate of patients. DEGs and hub genes identified in this study contribute to our understanding of differential genes and biological processes in the development and progression of early-stage CRC, providing possible targets for the early diagnosis and treatment of CRC.
A search for a secular variation of the gravitational constant using strong gravitational fields
Authors: Le T. D. 
Published: August 2022

Abstract
Searching for varying dimensionless physical constants presents a meaningful characteristic in experimental and observational studies. One of the most valuable explorations of these variations could depend on the evolution of white dwarf stars. Applying the spectrum of white dwarf star: G191-B2B, we derive a robust limit on the cosmological variation of the gravitational constant. This limit proposes a potential test of the framework of modern unification theories.
The Use of Nitrate Reductase Activity for the Appraisal of Nitrogen Status and Productivity of Grapefruit Orchard Trees
Authors: Bar-Akiva A. , Shaked A. , A. J. 
Published: August 2022

Abstract
Mature Marsh seedless grapefruit trees on Sour orange stock planted in a loamy soil were subjected to three levels of nitrogen fertilization with and without phosphate or chicken manure added. The details of the experimental plan and tree responses during the five-year experimental period will be described elsewhere. Briefly, the phosphate and manure treatments resulted in a significant increase in yield and in improved fruit quality. As far as the leaf composition is concerned, the phosphate and manure treatments caused an increase in the P and a decrease in the N content of the leaves, thus producing a completely inverse relationship between leaf N concentration and the yield of the corresponding trees. This situation served as an opportunity to test—under orchard. conditions—the validity of NaR (nitrate reductase) assay in leaves as a measure for some “active fraction” of leaf nitrogen and as a parameter for tree productivity. The use of the NaR assay has been suggested for the determination of N requirements of citrus trees (1).
Cantaloup Breeding Line B66-5: Highly Resistant to Watermelon Mosaic Virus 1
Authors: Webb R. E. 
Published: August 2022

Abstract
Major programs of crop improvement through breeding include the development of germ plasm resistant to diseases. Cantaloup improvement is no exception and control of diseases through resistance has been highly successful in this crop during the last half century (5). However, minor diseases, and new ones, frequently become major menaces to production through radical changes in environment and in crop management practices, and also through the introduction of crops that harbor the pathogens or vectors.
Seed Legislation in the United States
Authors: Rollin S. F. 
Published: August 2022

Abstract
Seed legislation in the United States consists of two primary categories; Federal legislation, and state legislation. Federal legislation is contained in the Federal Seed Act of August 9, 1939, as amended; and state legislation is contained in seed laws of each of the 50 states. Each state seed law applies to seed sold or offered for sale within that state. The Federal Seed Act applies to seed moving in interstate commerce. In addition, the Federal Seed Act applies to foreign commerce; that is, to seed offered for importation into the United States. The Federal Seed Act does not regulate seed exported from the United States.
Free Amino Acids of Dormant Rhubarb Crowns
Authors: Tompkins D. R. , Kimura Y. 
Published: August 2022

Abstract
Dormant rhubarb crowns do not force well until their rest period or physiodormancy (7) has been broken by sufficient chilling in the field during late fall. There are many reports that during exposure of dormant plants to cold, the free amino acids contents change. Asen and Stuart (1) found that dormant leaves and buds of Hydrangea macrophylla showed an increase of some free amino acids after 6 weeks of storage at 4 to 5°C. Another worker (8) reported that in one alfalfa variety there was a 20% increase of acids from August to December. Schneider (4) found that the levels of some free amino acids in leaves of Ilex crenata nigra rooted cuttings changed during storage at cool temperatures. In this study buds and roots of dormant rhubarb crowns were analyzed to determine the free amino acids present and also possible changes in acids levels that might indicate the end of the rest period.
The Use of PI Soybeans as an Indicator Plant for the Selection of Chlorosis Resistant Horticultural Plants1
Authors: LaCroix L. J. , Lenz L. M. 
Published: August 2022

Abstract
Iron deficiency chlorosis is a serious problem when many of a number of woody and herbaceous ornamental and fruit plants are grown on calcareous soils. Soil amendments, such as the various iron chelates, have been used with varying success (1,2,3,4), however, except for foliar application on citrus, chelates have found limited use because of their high cost and erratic or less than satisfactory results. The simple inheritance of chlorosis resistance in soybeans is well known (5), however, the few attempts to select chlorosis resistant fruit trees have been rather unsuccessful (6,7). Trees frequently will show no signs of chlorosis until the rcot system penetrates highly calcareous subsoil layers. Thus attempts to select for chlorosis resistance have given erratic year to year results and have, in general, been unsuccessful even after several years of testing.