bluuebunny/crossref_metadata_2025_split huggingface dataset:
Schizophrenia Diagnosis via FFT and Wavelet Convolutional Neural Networks utilizing EEG signals
Authors: Saeedi Maryam , Saeedi Abdolkarim , Mohammadi Pooya 
Published: March 2022

Abstract
BackgroundSchizophrenia is a chronic mental illness in which a person's perception of reality is distorted. Early diagnosis can help to manage symptoms and increase long-term treatment. The electroencephalogram (EEG) is now used to diagnose certain mental disorders. MethodIn this paper, we developed an artificial intelligence methodology built on deep convolutional neural networks with specialized layers. In the first phase, we used the Gramian Angular Field (GAF) including two methods: Gramian Angular Summation Field (GASF) and Gramian Angular Difference Field (GADF) to represent the EEG signals as various types of images. Then, well-known CNN architectures includes of Transformer CNN-LSTM and two new custom architectures which utilizing two-dimensional Fast Fourier transform layers (CNN-FFT) and wavelet transform layers (CNN-Wavelet) are preformed to extract useful information from the data. These layers allow automated feature extraction from EEG representation in the time and frequency domains. ResultsCNN-FFT and Transformer models derive most valuable features from signals based on the findings. CNN-FFT obtained the highest accuracy of 99.04 percent. Transformer, which has a 98.32 percent accuracy rate, also performs admirably. ConclusionThis experiment outperformed other previous studies. Consequently, the strategy can aid medical practitioners in automated detection and early treatment of schizophrenia. The code of the work is also publicly available on github: https://github.com/i1idan/schizophreniadiagnosis-eeg-signals
Comparing CMIP6 climate model simulations of annual global mean temperatures to data
Authors: Guttorp Peter , Craigmile Peter 
Published: March 2022

Abstract
A new approach to validating climate models is introduced. First, four data series are combined into one data product
using a hierarchical statistical approach. The resulting estimates of trend and residual spectral density functions are provided with simultaneous error bands. A similar decomposition is made for CMIP6 historical simulations, and the trend and spectral density estimates are plotted on top of the data-based bands. We find that 4 out of 58 models have trends fitting inside the bands, and that 6 out of 58 have spectral density functions agreeing with the data. The difference in the
average temperatures from 1995--2014 relative to 1880--1899 is more often smaller in the model runs than in the data.
In Cellulo Kinase Screen Identifies Potential MASTL Substrates
Authors: Marzec Kamila A , Rogers Samuel , McCloy Rachael , Parker Benjamin L , James David E , Watkins D. Neil , Burgess Andrew 
Published: March 2022

Abstract
MASTL (microtubule-associated serine/threonine kinase-like) has emerged as a critical regulator of mitosis and as a potential oncogene in a variety of cancer types. To date, Arpp-19/ENSA are the only known substrates of MASTL. However, with the roles of MASTL expanding and increased interest in development of MASTL inhibitors, it has become critical to determine if there are additional substrates and what the optimal consensus motif for MASTL is. Here we utilized a whole cell lysate (in cellulo) kinase screen approach combined with stable isotope labelling of amino acids in cell culture to identify potential substrates and a consensus motif of MASTL. Using the related AGC kinase family members AKT1/2, the in cellulo assay identified several known and new substrates highly enriched with the validated consensus motif for AKT. Applying this method to MASTL identified 59 phospho-sites on 26 novel proteins significantly increased in the presence of active MASTL. Subsequent in vitro kinase assays confirmed that MASTL was capable of phosphorylating hnRNPM, YB1, RPS6, TUBA1C, and RPL36A under some conditions. Taken together, these data suggest that MASTL may phosphorylate several additional substrates, providing insight into the ever-increasing biological functions and roles MASTL plays in driving cancer progression and therapy resistance.
miR-138 from adipose-derived stem-cell exosomes accelerates wound healing in diabetic rats through targeting SIRT1/PTEN signaling to promote angiogenesis and fibrosis
Authors: Li Maoquan , Li Xue , Hu Nan , Zhang Miaomiao , Han Jianhong , Sun Yi , HualanYang  
Published: March 2022

Abstract
Background: Exosome (Exo) secretion by adipose-derived mesenchymal stem cells (ADSCs) promotes cutaneous wound healing through the transfer of bioactive molecules. miR-138 is a micro (mi)RNA that stimulates endothelial progenitor cells and promotes the proliferation and locomotion of human scar fibroblasts (HSFs). However, the underlying molecular mechanism is unclear. Methods: miR-138 activity in Exo-mediated healing was investigated through isolating exosomes by ultracentrifugation from control ADSCs or ADSCs expressing miR-138 and injecting them into full-thickness skin wounds in a rat diabetes model. Wound healing was evaluated according to the wound closure rate, histology, and immunofluorescence staining. Cultures of HSFs and human mammary epithelial cells (HMECs) were treated with Exos from wild-type and miR-138-modified ADSCs under high glucose (HG) conditions. Cell proliferation and apoptosis were measured with cell counting kit (CCK)-8 assays and flow cytometry. Cell migration was assayed in Transwell chambers, and the effects of miR-138 on Exo-mediated angiogenesis and protein expression were evaluated. The miR-138 targets were identified with luciferase reporter assays. Results: ADSC-Exos were incorporated by endothelial cells and HSFs, and miR-138 enhanced cell proliferation and migration and suppressed apoptosis under HG conditions. Exos promoted endothelial tubule formation by HMECs, and western blotting showed that miR-138 mediated the therapeutic effects by reversing SIRT1/PTEN-mediated PI3K/Akt and ERK1/2 signaling inhibition. Luciferase reporter assays confirmed that miR-138 interacted with the 3'-UTR of SIRT1 and subsequently suppressed SIRT1 mRNA expression. Injection of miR-138-enriched Exos into skin wounds accelerated re-epithelialization, decreased scar width, and enhanced angiogenesis. Conclusions: In conclusion, miR-138-enriched Exos promoted wound healing in a rat diabetes model by targeting SIRT1, and their effects in promoting soft tissue wound healing warrant further study.
Concepts of Pathology from Ancient India-A Review of Sanskrit Literature
Authors: Lahori Mega 
Published: March 2022

Contribution by ancient physicians from the Indian subcontinent towards the field of pathology has been largely unknown globally. This paper aims at providing a glimpse of the knowledge possessed by the Sanskrit scholars of ancient times (derived from Sanskrit texts written originally between 1500 B.C. and 1500 A.D) regarding the basis of disease and correlating their ideas with our present understanding of the concepts in Pathology. Ayurveda (traditional Indian medicine) was developed in India during the Vedic age (approximately 1500-500 BC). The early ayurvedic practitioners gave due importance to etiopathogenesis of diseases as a separate field called Nidana-shastra. (Nidāna means etiology or cause). Charaka emphasized that illness is caused by imbalance of the three principles (doshas) - vata, pitta and kapha, and that genetic defects are transmitted by either the sperm or the ovum. Sushruta depicted various modes of communicable disease transmission - physical contact, exhaled air, close contact, fomites etc, Madhava classified diseases based on pathogenesis (primary or secondary), etiology (endogenous or exogenous) and prognosis (curable, incurable, mild and acute). Chakrapani propounded that epidemics in a community occur due to deterioration of factors that are common to all who inhabit that community- namely air, water, soil, food, etc. Vagabhatta emphasized the importance of personal hygiene and proper nutrition for good health and elaborated the role of contaminated river water in several diseases. Agada tantra is the science of poisons and their antidotes which was founded by Kashyapa.
Auditing Histopathology Processes to Augment Reporting Quality: An Objective Analysis in a Tertiary Care Neuropathology Laboratory
Authors: Pant Ishita , Chaturvedi Sujata , Tripathi Chandra Bhushan , Goel Anchit , Sarma Pragyan , Satti Dinesh Kumar 
Published: March 2022

Background: Laboratory audits are an integral component of the continuous quality improvement process and one of the key elements of quality control in the laboratories. These audits are primarily concerned with the everyday aspects of laboratory services and are a means of providing feedback to the users of the laboratory and its staff. These audits measure the performance of laboratory services against established standards that are evidence based and established by the audit team itself. This original study was initiated with an objective to audit all those histopathology processes that are involved in the generation of a quality histopathology report. The purpose was to detect the gaps which in turn maybe used to reduce and avoid errors in the processes, thus improvising the quality assurance practices of the histopathology laboratory.
Materials and Methods: In this retrospective cross- sectional study, total twenty standards were audited, including the clinical details, the pre-analytical, analytical and post-analytical laboratory processes.
Results: Overall, out of the 20 standards audited it was found that in the first audit, full compliance was observed in 10 standards, whereas the re-audit showed full compliance in 11 standards. Undoubtedly the compliance showed an improving trend in the re-audit.
Conclusion: such laboratory-based audits not only form an integral component of the quality assurance programs but definitely add on to the quality of patient care, as the reports generated by the histopathology laboratories do help the treating team in deciding or modifying the treatment plan in central nervous system and spinal tumours.
Turismo religioso e combate à intolerância em tempos de covid 19:
Authors: Thaywani Pereira Vieira Jackelyn , Guimarães Valeria Lima 
Published: March 2022

O presente artigo desdobra-se de uma dissertação de mestrado em Turismo defendida em 2021, que teve como foco o turismo religioso na cidade de Teresópolis-RJ, com destaque para a umbanda, e amplia a discussão para o contexto da covid-19. A cidade foi escolhida por ter muitos templos religiosos de matriz africana e também por apresentar fortes registros de intolerância religiosa comprovados pelo Estado nos últimos anos. O trabalho pretende fazer uma contribuição para o debate sobre a inserção das religiões de matriz africana no turismo e alertar para o crescente número de casos de agressões aos templos religiosos e também aos seus manifestantes, reforçando a importância do respeito à diversidade religiosa. Com um olhar atento para as atividades de um centro de umbanda e de um santuário umbandista, ambos localizados na referida cidade, é feita uma análise sobre o potencial turístico do local. O estudo aponta também os impactos da pandemia de covid-19 nas atividades do centro e do santuário de umbanda pesquisados e seus reflexos sobre a prática do turismo religioso. Para tanto, foram realizadas pesquisas bibliográficas, participação em eventos de turismo religioso (online) que abordaram a questão da pandemia, e pesquisa de campo com observação direta. O trabalho é concluído com a apresentação das formas de resistência e das estratégias construídas pelos religiosos umbandistas para a manutenção da sua fé no contexto da pandemia e fortalece o argumento da importância do turismo religioso como um possível agente promotor do respeito à diversidade religiosa e cultural.
Palavras-chave: Turismo Religioso. Umbanda. Teresópolis-RJ. Covid-19.
A Mini-Review on Pyridazine Analogs: Chemical and Pharmacological
Potentials
Authors: Asif Mohammad , Alghamdi Saad 
Published: March 2022

Abstract:
The pyridazinone derivatives have diverse biological potential and are easily synthesized.
Due to this, researchers and chemists have paid attention to the design and development of novel and
effective bioactive compounds. The substituted pyridazines have shown a wide range of pharmacological
activities, such as analgesic, anti-inflammatory, antibacterial, antifungal, anticonvulsant, antidepressant,
antianxiety, antitubercular, anti-malarial, anticancer, anti-HIV, platelet inhibitory, hypotensive,
cardiotonic, etc. In the current circumstances, it can be concluded that pyridazinone derivatives
have great prospects, which remain to be revealed.
A Mini-review on Nanodelivery Systems as Therapeutics in Cancer
Authors: Bisht Gopal Singh , Sharma Deepika 
Published: March 2022

Abstract:
This review article gives a brief account of advances in the treatment of cancer via
nanodelivery systems. We have discussed benefits of different nanocarriers that have the potential to
deal with the problem of non-selectivity of conventional anticancer drugs. Targeted drug delivery
not only spares healthy cells from harmful effects of anticancer drugs but also reduces the amount of
drug to be administered; various drug delivery systems have been fabricated using appropriate
nanocarriers. In fact, some carrier systems are biodegradable and degrade in the body into nontoxic
moieties, thereby adding safety characteristics to the formulation. Selectivity towards cancer cells
makes nanodelivery system a choice for the treatment of cancer as compared to conventional drug
delivery. This review discusses various targeting strategies, different nanodelivery systems, characteristics
required to be an ideal drug delivery system, advantages of these systems, and future prospects
of such systems.
Wild Thyme Herbal Infusion Consumption Suppresses Tumor Growth in a
Murine Model of Breast Cancer
Authors: Talib Wamidh H. , AL-Ataby Israa A. 
Published: March 2022

Background:
Wild thyme (Thymus serpyllum) belongs to the Lamiaceae family. They were used traditionally to treat different sorts of diseases, including cancer.

Aims:
The current study aims to evaluate both anticancer and immunomodulatory activities of wild thyme water extract.

Methods:
The antiproliferative activities of the extract were tested against different cancer cell lines using MTT assay, while the degree of apoptosis induction and VEGF expression were detected using ELISA. The lymphocyte proliferation assay was used to evaluate the acquired immunity, whereas both: the nitro blue tetrazolium assay and the neutral red method were used to assess the innate activity; phag-ocytosis and pinocytosis, respectively. Balb/C mice were inoculated with the EMT6/P breast cancer cells and received the extract orally for 14 days. GC-MS and LC-MS were used to determine the com-position of the wild thyme water extract.

Results:
Results showed that wild thyme had significant apoptosis induction and angiogenesis suppres-sion effects. The extract stimulated lymphocyte proliferation, phagocytosis and pinocytosis strongly. Seventy percent (70%) of the mice taking this extract did not develop tumors, with a percentage of tumor reduction (49.4%). Rosmarinic acid was the highest in the wild thyme water extract in GC-MS and LC-MS.

Conclusion:
Wild thyme herbal infusion is rich in phytochemicals that have the potential to activate the immune system and inhibit tumor progression. Further testing is required to understand the exact molecular mechanisms of this extract. Further studies are also needed to test the wild thyme infusion against tumors established in mice.
Methodological Aspects and the Prognostic Value of Metabolic Tumor
Volume assessed with 18F-FDG PET/CT in Lymphomas
Authors: Tutino Francesca , Giovannini Elisabetta , Pastorino Sara , Ferrando Ornella , Giovacchini Giampiero , Ciarmiello Andrea 
Published: March 2022

Abstract:
Although metabolic tumor volume (MTV) assessed with pretreatment 18F-FDG PET/CT has shown significant prognostic value across many lymphoma types, it is still not used in clinical practice due to technical concerns and the lack of standardisation. Numerous studies on the prognostic value of MTV in lymphomas have been published in recent years, but there is still no full agreement on the best methodology for MTV calculation. In this paper, we reviewed the methodological aspects of MTV assessment and reported recent works about its impact on outcome in lymphomas, with a focus on Hodgkin lymphoma (HL) and diffuse large B cell lymphoma (DLBCL).
A Current Review of Systemic Lupus Erythematosus Treatment Using
Monoclonal Antibodies
Authors: Shinde Rohan G. , Patel Vipul P. , Gundgole Shwetarani D. , Dhumale Suchita S. , Dhole Snehal D. 
Published: March 2022

Abstract:
Lupus is a heterogeneous and inflammatory autoimmune disease that affects the immune
system of the body. This disease affects multiple tissues and organs. The most frequent kind of lupus
is systemic lupus erythematosus (SLE). SLE is an autoimmune illness in which the immune system
targets the body's tissues, resulting in extensive inflammation and tissue destruction in the organs
involved. Joints, skin, brain, lungs, kidneys, and blood vessels can all be affected. It appears to
be a form of B-cell disease in which autoantibodies attack the cells. Systemic lupus erythematosus
autoimmune diseases involve different treatment methods. These abnormalities are due to the presence
of autoantibodies, and these contribute to the degeneration of the body’s immune system. In
this review, we will focus on various therapies, including SLE treatments, such as B-cell therapy,
cytokine therapy, interferon targets, and anticomplementary therapies, all of which have become
challenging. We will also discuss post-marketing use and ongoing clinical trials, as well as safety
and effective doses.
The Effect of Stretch Goals on Destructive Leadership and Counterproductive Work Behavior in Indonesian State-Owned-Enterprises
Authors: Wulandaru Diah Retno , Ciptono Wakhid Slamet , Susanto Ely 
Published: March 2022

Introduction/Main Objectives: This study aims to examine the effect of stretch goals on destructive leadership with burnout as the mediating variable­­­ and then the effect of destructive leadership on counterproductive work behavior of employees with psychological capital as a moderating variable. Background Problems: The phenomenon of irregularities that occur in SOE in Indonesia is interesting to study. Deviations committed by SOE leaders in Indonesia include fraud, gratification, and data manipulation. The increase in the number of irregularities has a negative effect on organizational performance because it causes several counterproductive work behaviors in employees. Novelty: Empirical research on destructive leadership is still rare because previous research has focused only on the conceptual side. Research Methods: The design of this study used a survey with a questionnaire completed by 724 respondents who were leaders and employees. The hypothesis testing used Structural Equation Modeling (SEM). Finding/Results: The findings of this study show a positive influence of stretch goals on burnout and a positive influence of stretch goals on destructive leadership, but burnout has no mediating role in the effect of stretch goals on destructive leadership. There is no effect of perceived destructive leadership on employees’ counterproductive work behavior, but psychological capital has a moderating role in the effect of perceived destructive leadership on employees’ counterproductive work behavior. Conclusion: The practical implication of this study is that a stretch goal that is not balanced with resources can cause individuals to behave destructively even though they are at a managerial level.
Reflection of the Problems of Interethnic Relations in the Russian Media
Authors: Ledeneva V. Yu. 
Published: March 2022

The article is an attempt to comprehend the current publications of the Russian media space in the context of various aspects of national and ethnic identity, harmonization of interethnic relations. The authors consider the images of external labor migrants constructed by the media (hereinafter referred to as the media), and the negative attitudes that have developed in society towards them.Aim. The aim of the article is to show the problems of objectivity in the presentation of information about interethnic relations in the Russian media, to determine how publications in the media form the level of tolerance in society, and also to identify the role of the media space in countering the spread of xenophobia, nationalism and neo-fascism.Tasks. To achieve this goal, the article solves several key tasks: the concept of “interethnic relations” is analyzed, the factors determining their state and conflict potential are identified, the mechanism of discursive construction of interethnic relations is revealed, differences in approaches to covering interethnic conflicts in various Russian print and electronic publications are shown.Methods. The methodological basis of the work was the scientific methods of comparative system analysis, aimed at a comprehensive study of the media as a mechanism for regulating interethnic relations. The main method was content analysis of texts of print and electronic federal and regional media, articles, messages, Internet editions, bloggers’ comments, messages on social networks and text messages from various sources reflecting the problems of interethnic relations. Intent analysis of publications made it possible to determine a set of lexemes, the purpose of which is to create a negative image of the subject of the story.Results. Based on the results of the content analysis, the main substantive and evaluative characteristics of interethnic relations in society, the contradictions in the formation of the image of external migrants present in the modern media space and a description of possible interaction strategies that Russian society is ready for at present were identified. The mechanism of discursive construction in the form of texts that provoke emotional perception of external migration over texts that contribute to its rational comprehension has been determined.Conclusions. The analysis showed the weak role of the media in reflecting the problems of interethnic relations. Functionally, the activities of the media are aimed at ensuring interethnic harmony and regulating interethnic relations, however, to a greater extent, negative rhetoric towards foreign migrants prevails in the Russian media, which increases the level of migrant phobia among the population.