bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dinuclear Copper(I) Complexes Supported by Bis‐Tridentate N‐Donor‐Ligands: Turning‐On Tyrosinase Activity
Authors: Schneider Rebecca , Engesser Tobias A. , Hamann Jessica N. , Näther Christian , Tuczek Felix 
Published: September 2022

AbstractFour structurally related bis‐tridentate N‐donor ligands with either two secondary amine or two imine functions were synthesized, and the corresponding dicopper(I) complexes were investigated as catalysts for the tyrosinase‐like conversion of 2,4‐di‐tert‐butylphenol (DTBP‐H) to 3,5‐di‐tert‐butylquinone (DTBQ). Notably, the imine systems show evidence for both a μ‐η2 : η2‐peroxo‐dicopper(II) species and catalytic conversion of DTBP‐H to DTBQ. Moreover, kinetic studies indicate that a dinuclear copper‐oxygen species is involved in the monooxygenation of DTBP‐H. In contrast, the amine systems do not show monooxygenase activity. Comparison of the experimentally determined catalytic activities with DFT‐optimized geometries of μ‐η2 : η2‐peroxo‐dicopper(II) intermediates suggests that the ligand rigidity of the imine systems allows equatorial attack of the substrate and, thus, subsequent monooxygenation whereas this is not possible in the amine systems due to the fact that no free equatorial positions are available in the μ‐peroxo intermediate.
Supporting men or male privilege? Women's progressive and reactionary collective action for men
Authors: Mikołajczak Gosia , Becker Julia C. 
Published: September 2022

AbstractCollective action for other groups, such as men's action for women, has usually been analysed as social protest advancing equality of disadvantaged groups. In the current research we extend collective action literature by applying SIMCA predictors—identity, injustice, efficacy—to investigate action in support of an advantaged group (women's action for men) and by distinguishing its progressive and reactionary forms. Across three online samples of women (Study 1: N = 1825 US; Study 2: N = 679 UK; Study 3: N = 429 US), we show that support for reactionary action reinforcing male privilege is associated with outgroup identification and outgroup injustice. Conversely, progressive action supporting men in adopting egalitarian gender roles is associated with outgroup identification, outgroup‐focused efficacy, and ingroup injustice. Importantly, some of these associations depend on the content of outgroup‐focused variables. We discuss the implications of our findings for collective action and gender research.
Leveraging machine learning to analyze sentiment from COVID‐19 tweets: A global perspective
Authors: Rahman Md Mahbubar , Khan Nafiz Imtiaz , Sarker Iqbal H. , Ahmed Mohiuddin , Islam Muhammad Nazrul 
Published: September 2022

AbstractSince the advent of the worldwide COVID‐19 pandemic, analyzing public sentiment has become one of the major concerns for policy and decision‐makers. While the priority is to curb the spread of the virus, mass population (user) sentiment analysis is equally important. Though sentiment analysis using different state‐of‐the‐art technologies has been focused on during the COVID‐19 pandemic, the reasons behind the variations in public sentiment are yet to be explored. Moreover, how user sentiment varies due to the COVID‐19 pandemic from a cross‐country perspective has been less focused on. Therefore, the objectives of this study are: to identify the most effective machine learning (ML) technique for classifying public sentiments, to analyze the variations of public sentiment across the globe, and to find the critical contributing factors to sentiment variations. To attain the objectives, 12,000 tweets, 3000 each from the USA, UK, and Bangladesh, were rigorously annotated by three independent reviewers. Based on the labeled tweets, four different boosting ML models, namely, CatBoost, gradient boost, AdaBoost, and XGBoost, are investigated. Next, the top performed ML model predicted sentiment of 300,000 data (100,000 from each country). The public perceptions have been analyzed based on the labeled data. As an outcome, the CatBoost model showed the highest (85.8%) F1‐score, followed by gradient boost (84.3%), AdaBoost (78.9%), and XGBoost (83.1%). Second, it was revealed that during the time of the COVID‐19 pandemic, the sentiments of the people of the three countries mainly were negative, followed by positive and neutral. Finally, this study identified a few critical concerns that impact primarily varying public sentiment around the globe: lockdown, quarantine, hospital, mask, vaccine, and the like.
Parametric experimental investigation of unbonded post‐tensioned reinforced concrete bridge piers under cyclic loading
Authors: Shen Yu , Freddi Fabio , Li Yongxing , Li Jianzhong 
Published: September 2022

AbstractThe present paper investigates the cyclic performance of unbonded post‐tensioned reinforced concrete (PRC) rocking piers by a parametric experimental campaign. PRC rocking specimens are assembled by hybrid connections, containing an ungrouted post‐tensioned (PT) bar and grouted mild steel bars, that is, energy‐dissipation (ED) components. The properties of a benchmark PRC pier were defined according to a design procedure to control its strength, ductility, energy dissipation capacity, and self‐centering behavior. Five additional PRC piers with different ED bars amounts, initial PT force, and ED bars unbonded lengths were also tested to investigate the influence of these parameters on the cyclic performance. The test results show the superior cyclic performance of the PRC pier in limiting both damage and residual deformations. The parametric analysis highlighted that decreasing the initial PT force and/or ED bars amount enhances the PRC's ED capacity at the expense of the lateral force resistance and self‐centering behavior. Moreover, it has been observed that the influence of ED bars’ unbonded length only minimally affects the PRC pier's cyclic performance due to ED bars’ bond‐slip and concrete cover spalling of the pier shaft. Analytical models describing the PRC piers’ lateral force‐drift cyclic behavior were formulated and calibrated, showing a good agreement with test results for all specimens. The results and findings provide a valuable reference and solution for tailoring an efficient parameter recommendation of PRC rocking piers.
Targeted Crystallization of Rare Earth Carbonate Polymorphs at Hydrothermal Conditions via Mineral Replacement Reactions
Authors: Szucs Adrienn Maria , Maddin Melanie , Brien Daniel , Guyett Paul Christopher , Rodriguez‐Blanco Juan Diego 
Published: September 2022

AbstractThe interaction between rare earth element (REE)‐rich (La, Pr, Nd, Dy) aqueous solutions, dolomite (CaMg(CO3)2), and aragonite (CaCO3) at low temperature hydrothermal conditions (25–220 °C) is studied. The experiments result in the solvent‐mediated surface precipitation and subsequent pseudomorphic mineral replacement of the dolomite and aragonite seeds by newly formed REE‐carbonates. The host grains are replaced from periphery inward. The newly formed REE‐bearing carbonates in La‐, Pr‐, and Nd‐doped systems follow the crystallization sequence: lanthanite [REE2(CO3)3·8H2O] → kozoite [orthorhombic REECO3(OH)] → hydroxylbastnasite [hexagonal REECO3(OH)]. The interaction of Dy‐bearing solutions with dolomite results only in the crystallization of kozoite [orthorhombic DyCO3(OH)]. However, experiments with aragonite reveal a two‐step crystallization pathway: tengerite [Dy2(CO3)3·2‐3(H2O)] → kozoite [orthorhombic DyCO3(OH)]. The temperature, the dissolution rate of the host mineral, and the ionic radii of the REE3+ in question are found to control the kinetics of the replacement reaction, the polymorph selection, and the crystallization pathways toward bastnasite. The findings allow to gain a more in‐depth understanding of the formation REE‐bearing carbonates, particularly the mineral bastnasite, which is the main source of REEs for industry. This knowledge can be used to improve REE separation, exploration, exploitation methods, as well to produce carbonate minerals with tailored structures.
The pain and depressive symptoms cascade: A bidirectional analysis of the Mexican Health and Aging Study 2012–2015
Authors: Gutierrez Sirena , Wong Rebeca , Milani Sadaf Arefi 
Published: September 2022

AbstractObjectivesThe association of pain and depression has not been evaluated in low‐ and middle‐income countries, which have a disproportionate burden of pain compared to high‐income countries.MethodsUsing data from the Mexican Health and Aging Study (baseline, 2012; follow‐up, 2015), we examined the bidirectional relationship between pain and depressive symptoms and identified shared predictors among community‐dwelling participants ≥60 years (n = 7237). Multivariable logistic regressions models evaluated the association between (1) baseline pain and incident elevated depressive symptoms and (2) baseline depressive symptoms and incident pain, adjusting for demographic, socioeconomic, and health‐related factors. Models included inverse probability weights and evaluated interactions by gender.ResultsParticipants (55.0% women) were on average 69.1 years old. Over half reported no pain (60.7%) and low/no depressive symptoms (67.9%) in 2012, of which, 20.2% reported elevated depressive symptoms and 25.3% self‐reported pain in 2015. Baseline pain was associated with higher odds of incident elevated depressive symptoms (aOR 1.65; 95% CI, 1.41–1.93). Baseline elevated depressive symptoms were associated with higher odds of developing pain (aOR 1.57; 95% CI, 1.32–1.87). Age, gender, self‐rated health, and activity of daily living limitations were shared risk factors for pain and elevated depressive symptomatology onset. Although the incidence of elevated depressive symptoms and pain was higher in women, there were no statistically significant interactions.ConclusionsOlder adults with pain or depression may be at risk for developing the other. These shared predictors could help identify patients in clinical settings, where pain and depression are often overlooked, reducing the cascading risk of this comorbidity.
Tracheostomy dependence following “organ preservation” (chemo)radiation protocol for laryngeal and hypopharyngeal cancers
Authors: Batchelor Clare Jing Jing , Flukes Stephanie Patricia 
Published: September 2022

AbstractBackgroundPatients receiving primary (chemo)radiotherapy for laryngeal or hypopharyngeal cancer risk developing severe laryngeal dysfunction and becoming tracheostomy dependent, detracting from the benefits of organ preservation. We aim to describe the airway outcomes for this cohort and identify risk factors for developing tracheostomy dependence.MethodsPatients with laryngeal or hypopharyngeal cancer who were recommended for and underwent primary (chemo)radiotherapy over a 6‐year period were identified from a tertiary hospital Head and Neck cancer database. Patient, tumor, and treatment details were collected and analyzed.ResultsOf 166 patients, 18.7% (N = 31) required tracheostomy insertion. Advanced tumor classification was the only significant predictor (p < 0.00001). Successful decannulation was observed in 12.9% (N = 4). Decannulation was observably less successful with advanced tumors, bilateral vocal cord immobility, tracheostomies inserted under emergency conditions.ConclusionWe quantified tracheostomy insertion rates and dependence in patients undergoing “organ‐preserving” (chemo)radiotherapy, to assist in the pre‐treatment counseling of patients opting for this approach.
Impacts of Cattaneo–Christov heat flux on the radiative MHD nanofluid flow past a stretched cylinder under multiple slip conditions
Authors: Bag Raju , Kundu Prabir K. 
Published: September 2022

AbstractThis investigation explores the features of velocity distribution, mass and heat transmissions of nanoliquid stream over a permeable cylinder accompanied by Cattaneo–Christov heat model and thermal radiation with nonlinear sort. Multiple slip conditions have been also encountered here. A magnetic force is oriented along vertically upward. The existence of thermophoresis together with Brownian motion has been assumed here. The foremost equations and associated boundary conditions have been normalized through the similarity technique. Then we solve the system numerically along with the fourth‐order Runge–Kutta shooting scheme by using the software MAPLE‐17 and round it with our preassigned accuracy level. The obtained outcomes are epitomized by tables and graphs. All of the impacts have been compared in suction and injection correspondingly and explained with proper reasoning. In charts, the physical consignments (such as Sherwood number, Nusselt number and skin friction) reveal the transference of mass and temperature and amount of friction by nanoparticles in the nanocomposition. For suction, the nanofluidic temperature gradually diminished due to the advanced thermal relaxation, whereas the contrary fact is exhibited in injection. The relaxation parameter of concentration provides a positive influence on mass transmission. The rates of amplification of this transportation are 1.99% and 3.87%, measured in consideration of injection and suction, respectively. Thermal radiation influenced the fluid's temperature in a positive direction. It increases Nusselt number with 41.75% in suction, and 45.21% is recorded for injection.
Adherence to a risk‐adapted screening strategy for prostate cancer: First results of the PROBASE trial
Authors: Krilaviciute Agne , Albers Peter , Lakes Jale , Radtke Jan Philipp , Herkommer Kathleen , Gschwend Jürgen , Peters Inga , Kuczyk Markus , Koerber Stefan A. , Debus Jürgen , Kristiansen Glen , Schimmöller Lars , Antoch Gerald , Makowski Marcus , Wacker Frank , Schlemmer Heinz , Benner Axel , Giesel Frederik , Siener Roswitha , Arsov Christian , Hadaschik Boris , Becker Nikolaus , Kaaks Rudolf 
Published: September 2022

AbstractPROBASE is a population‐based, randomized trial of 46 495 German men recruited at age 45 to compare effects of risk‐adapted prostate cancer (PCa) screening starting either immediately at age 45, or at a deferred age of 50 years. Based on prostate‐specific antigen (PSA) levels, men are classified into risk groups with different screening intervals: low‐risk (<1.5 ng/ml, 5‐yearly screening), intermediate‐risk (1.5‐2.99 ng/ml, 2 yearly), and high risk (>3 ng/ml, recommendation for immediate biopsy). Over the first 6 years of study participation, attendance rates to scheduled screening visits varied from 70.5% to 79.4%, depending on the study arm and risk group allocation, in addition 11.2% to 25.4% of men reported self‐initiated PSA tests outside the PROBASE protocol. 38.5% of participants had a history of digital rectal examination or PSA testing prior to recruitment to PROBASE, frequently associated with family history of PCa. These men showed higher rates (33% to 57%, depending on subgroups) of self‐initiated PSA testing in‐between PROBASE screening rounds. In the high‐risk groups (both arms), the biopsy acceptance rate was 64% overall, but was higher among men with screening PSA ≥4 ng/ml (>71%) and with PIRADS ≥3 findings upon multiparameter magnetic resonance imaging (mpMRI) (>72%), compared with men with PSA ≥3 to 4 ng/ml (57%) or PIRADS score ≤ 2 (59%). Overall, PROBASE shows good acceptance of a risk‐adapted PCa screening strategy in Germany. Implementation of such a strategy should be accompanied by a well‐structured communication, to explain not only the benefits but also the harms of PSA screening.
Simultaneous robot‐assisted nephroureterectomy and radical cystectomy
Authors: Yajima Shugo , Nakanishi Yasukazu , Yasujima Rikuto , Hirose Kohei , Sekiya Ken , Umino Yosuke , Okubo Naoya , Kataoka Madoka , Masuda Hitoshi 
Published: September 2022

IntroductionWe present a case of simultaneous robot‐assisted radical nephroureterectomy (RANU) and robot‐assisted radical cystectomy (RARC) for muscle‐invasive bladder cancer with concomitant upper urinary tract urothelial carcinoma.Case presentationA 59‐year‐old Japanese man was diagnosed with right ureteral cancer and muscle‐invasive bladder cancer. We performed RANU and RARC simultaneously; three of the ports used for RANU were diverted to RARC. Console times for RANU and RARC were 66 and 207 minutes, respectively. Total operative time was 386 minutes. The intraoperative blood loss was estimated 255 ml. The patient was discharged on postoperative day 18 without complications.ConclusionWe reported our experience with simultaneous RANU and RARC for muscle‐invasive bladder cancer with concomitant right ureteral cancer. To the best of our knowledge, this is the first report of its kind in Japan.
Polyphyllin I improves myocardial damage in coronary artery disease via modulating lipid metabolism and myocardial apoptosis
Authors: Yang Zhao , Yang Xuming , An Mingchun 
Published: September 2022

AbstractPolyphyllin I (PPI) is a famous traditional medicine ingredient, which has been explored in wide range of areas. Nevertheless, whether PPI exerts any functions in coronary artery disease (CAD) is still uncertified. Herein, we probed the effect and mechanism of PPI on lipid metabolism and myocardial dysfunction in myocardial cells and CAD rat model. Hypoxia/reoxygenation (H/R)‐treated H9c2 cells model was constructed for the in vitro experiments, and CAD model in vivo was established by high‐fat feeding. After management with PPI, the correlated factors of lipid metabolism and myocardial function were investigated. The apoptosis of myocardial cells was assessed by Annexin V‐FITC/PI kit and TUNEL staining. The apoptosis‐associated factors (caspase 3, cleaved caspase 3, Bax, and Bcl‐2) were tested by Western blot analysis. The MEK/ERK inhibitor was applied and the functions of MEK/ERK pathway in myocardial damage were investigated. H/R‐treated H9c2 cells model was constructed for the in vitro experiments, and CAD model in vivo was established by high‐fat feeding. After management with PPI, the correlated factors of lipid metabolism and myocardial function were investigated. The apoptosis of myocardial cells was assessed by Annexin V‐FITC/PI kit and TUNEL staining. The apoptosis‐associated factors (caspase 3, cleaved caspase 3, Bax, and Bcl‐2) were tested by Western blot analysis. The MEK/ERK inhibitor was applied and the functions of MEK/ERK pathway in myocardial damage were investigated. PPI improved lipid metabolism disorder in H/R‐induced H9c2 cells or in CAD rat model. Additionally, PPI attenuated myocardial dysfunction in CAD rats via enhancing left ventricular systolic pressure, maximum rate of change of left ventricular pressure (±dp/dtmax), and arterial blood flow (CF). The apoptosis of myocardial cells was lessened by PPI management, which was further verified by reducing Bax and cleaved caspase 3 expression. Furthermore, PD0325901 (MEK/ERK inhibitor) weakened the effect of PPI on myocardial dysfunction, lipid metabolism, and myocardial cell apoptosis in CAD rats. The research confirmed the protective effect of PPI on myocardial damage in CAD, which was regulated by MEK/ERK pathway.
CRISPR/Cas9‐HPV‐liposome enhances antitumor immunity and treatment of HPV infection‐associated cervical cancer
Authors: Zhen Shuai , Qiang Rong , Lu Jiaojiao , Tuo Xiaoqian , Yang Xiling , Li Xu 
Published: September 2022

AbstractIncreasing evidence shows that human papillomavirus (HPV) E6/E7 deletion in cervical cancer cells may be related to the immunosuppressive tumor microenvironment and adverse reactions or resistance to immune checkpoint blockade. Here, we demonstrate that liposome delivery of CRISPR/cas9 can effectively knock out HPV, which, in turn, induces autophagy and triggers cell death‐related immune activation by releasing damage‐related molecular patterns. The results of in vivo experiments showed that HPV‐targeting guide RNA–liposomes could promote CD8+ T cell infiltration in tumor tissues; enhance the expression of proinflammatory cytokines, such as interleukin‐12, tumor necrosis factor‐α, and interferon‐γ, and reduce regulatory T cells and myeloid suppressor cells. The combination of HPV‐targeting guide RNA–liposomes with immune checkpoint inhibitors and antiprogrammed death‐1 antibodies produced highly effective antitumor effects. In addition, combination therapy induced immune memory in the cervical cancer model.
SARS‐CoV‐2 and natural infection in animals
Authors: Qiu Xinyu , Liu Yi , Sha Ailong 
Published: September 2022

AbstractSevere acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) is the causative agent of the novel coronavirus disease (COVID‐19) pandemic, which has caused serious challenges for public health systems worldwide. Due to the close relationship between animals and humans, confirmed transmission from humans to numerous animal species has been reported. Understanding the cross‐species transmission of SARS‐CoV‐2 and the infection and transmission dynamics of SARS‐CoV‐2 in different animals is crucial to control COVID‐19 and protect animal health. In this review, the possible animal origins of SARS‐CoV‐2 and animal species naturally susceptible to SARS‐CoV‐2 infection are discussed. Furthermore, this review categorizes the SARS‐CoV‐2 susceptible animals by families, so as to better understand the relationship between SARS‐CoV‐2 and animals.
Adaptive immune responses in patients requiring revision after total knee arthroplasty
Authors: Jenkins Daniel , Phalke Swati , Bell Richard , Lessard Samantha , Gupta Sanjay , Youssef Mark , Tam Kathleen , Nocon Allina , Rivera‐Correa Juan , Wright Timothy , Sculco Thomas , Otero Miguel , Pernis Alessandra B. , Sculco Peter 
Published: September 2022

AbstractDissatisfaction occurs in nearly 20% of patients after total knee arthroplasty (TKA); however, there remains only limited understanding of the biologic mechanisms that may contribute to suboptimal postoperative outcomes requiring revision surgery. Expansion of effector T and B cells, could promote an abnormal healing response via local or peripheral immune system mechanisms and contribute to inferior outcomes necessitating revision TKA. In this pilot study, we hypothesized that patients suffering from complications of arthrofibrosis or instability may exhibit differences in adaptive immune function.Patients (n = 31) undergoing revision TKA for an indication of arthrofibrosis or instability were prospectively enrolled. Whole blood and synovial fluid (SF) from the operative knee were collected at time of surgery. Peripheral blood mononuclear cells were isolated and analyzed by flow cytometry. Serum and SF were assessed for immunoglobulin levels by Luminex and antiphospholipid antibodies by enzyme‐linked immunoassay.No significant differences were observed in peripheral blood T/B cell populations or serum immunoglobulins levels between groups. SF analysis demonstrated significant differences between the two groups, with higher levels of immunoglobulin G1 (IgG1) (p = 0.0184), IgG3 (p = 0.0084) and antiphosphatidyl serine IgG (p = 0.034) in arthrofibrosis relative to instability patients.Increased levels of both IgG subclasses and antiphospholipid antibodies in the SF suggest that intra‐articular T‐B cell interactions, potentially triggered by exposure to apoptotic components generated during post‐op healing, could be functioning as a source of immune complexes that fuel fibrous tissue growth in arthrofibrotic patients.