bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated With Referral of Children With a Femur Fracture to a Social Worker by an Orthopedist for Suspected Child Abuse
Authors: Yonai Yaniv , Ben Natan Merav , Finkel Binyamin , Klein Adi , Berkovich Yaron 
Published: September 2022

Objectives
This article explores factors associated with referral of children with a femur fracture to a social worker by an orthopedist for suspected child abuse.

Methods
This retrospective chart review study included 131 children younger than 5 years who sustained a femur fracture and were hospitalized in a major 495-bed hospital located in the northern-central Israel from 2009 to 2021. Data on children who were referred to a social worker by the treating orthopedist and those who were not were compared.

Results
More than half the children studied (58.8%, n = 77) were referred to a social worker by an orthopedist for suspected child abuse. However, only a fifth of these cases were eventually reported to the authorities. Male sex (odds ratio [OR], 2.44), younger age of the child (OR, 0.95), and spiral femur fracture type (OR, 5.30) increased the likelihood of referral. In addition, treatment of the child by an orthopedic specialist (as compared with an orthopedic resident; OR, 3.12) and lengthier professional experience of the treating orthopedist (OR, 1.08) increased the likelihood of referral.

Conclusions
Younger male children presenting with a spiral femur fracture have a higher likelihood to be referred to a social worker because of suspected child abuse by treating orthopedic specialists with lengthier professional experience. The findings point to the need to improve the capacity of orthopedic residents to report child abuse.
Provision of HIV preexposure prophylaxis to female patients seeking family planning services in the United States
Authors: Satish Sanjana , Bravo Licia , McAllister Arden , Teitelman Anne M. , Sonalkar Sarita 
Published: September 2022

Objective:
We conducted a scoping review to assess barriers to and facilitators of integrating HIV preexposure prophylaxis (PrEP) and family planning (FP) at the patient, provider, and implementation levels, and to identify gaps in knowledge.

Methods:
We conducted a search of five bibliographic databases from database inception to March 2022: PubMed, CINAHL, Embase, Web of Science and Scopus. Two reviewers screened abstracts and full texts to determine eligibility based on a priori inclusion and exclusion criteria. We categorized studies by their relevance to patient, provider, and implementation barriers, and extracted data based on prespecified elements.

Results:
Our initial search strategy yielded 1151 results, and 34 publications were included. Barriers to PrEP implementation in family planning settings included low PrEP knowledge among patients, hesitance to take PrEP due to perceived stigma, decreased willingness of providers unfamiliar with PrEP to prescribe PrEP, and limited financial and staffing resources that make prescribing and monitoring PrEP difficult. Facilitators included robust training for providers, stigma reduction efforts, leadership engagement, and increased resources specifically in settings with processes in place that ease the process of prescribing and monitoring PrEP.

Conclusions:
Advances in implementation strategy development, stigma reduction, and drug development will be essential to reinforcing PrEP care in family planning settings and thereby reducing the incidence of HIV in women through highly effective pharmacologic HIV prevention methods.
Comparing the Increased Intracranial Volume From Different Surgical Methods for Syndromic Craniosynostosis
Authors: Fang Cheng , Ji Min , Dong ChenBin , Li Jun , Ye XiuYa 
Published: September 2022

Purpose:
Fronto-orbital advancement (FOA) is the traditional surgical method used to increase intracranial volume, but posterior cranial vault distraction osteogenesis (PVDO) has been gaining popularity as an initial treatment option. This study aimed to compare the effects of FOA and PVDO on intracranial volume.

Patients and Methods:
Sixteen patients with multiple-suture synostosis and severe intracranial volume restriction were treated with FOA or PVDO at Children’s Hospital of Fudan University between January 2016 and December 2019. Data on age at surgery, sex, preoperative intracranial volume, and postoperative intracranial volume were collected.

Results:
Seven patients underwent FOA and 9 underwent PVDO. All patients underwent surgery for the first time, and the surgeries were performed by the same physician. There was no statistically significant difference in age at surgery or in the intracranial volumes before and after surgery between the 2 groups (P>0.05). There was a statistically significant difference in the intracranial volume changes between the 2 groups before and after surgery (P=0.028).

Conclusions:
Posterior cranial vault distraction osteogenesis provided statistically greater intracranial volume expansion than FOA.
Personality Traits in Patients With Cirrhosis Are Different From Those of the General Population and Impact Likelihood of Liver Transplantation
Authors: Thuluvath Avesh J. , Siddiqui Osama , Lai Jennifer C. , Peipert John , Levitsky Josh , Daud Amna , Mazumder Nikhilesh R. , Flores Anne-Marie , Borja-Cacho Daniel , Caicedo Juan C. , Loftus Corinne , Wong Randi , Mroczek Dan , Ladner Daniela P. 
Published: September 2022

Background.Personality traits influence clinical outcomes in chronic diseases, but their impact in cirrhosis is unknown. We studied the personality of patients with cirrhosis undergoing liver transplant (LT) evaluation and determined their correlation to clinical outcomes.Methods.A multicenter‚ prospective study of adult patients undergoing LT evaluation was performed from January 2018 to October 2019. The “Big Five” personality traits of conscientiousness, extraversion, openness, neuroticism, and agreeableness plus agency were assessed with the Midlife Development Inventory Personality Scale and compared with the general population. Frailty was assessed with the Liver Frailty Index.Results.Two hundred sixty-three LT candidates were enrolled. Twenty-four percent had hepatitis C virus, 25% nonalcoholic steatohepatitis, and 25% ethyl alcohol (mean model for end-stage liver disease = 15.7). Compared with the general population, LT candidates had higher openness (3.1 versus 2.9;P< 0.001), extraversion (3.2 versus 3.1;P< 0.001), agreeableness (3.5 versus 3.4;P= 0.04), agency (2.9 versus 2.6;P< 0.001), neuroticism (2.2 versus 2.1;P= 0.001), and lower conscientiousness (3.3 versus 3.4;P= 0.007). Patients with higher conscientiousness were more likely to receive an LT (HR = 2.76;P= 0.003).Conclusions.Personality traits in LT candidates differ significantly from the general population, with higher conscientiousness associated with a higher likelihood of receiving a transplant.
A genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity
Authors: Sarah Morris Siti Nur , Deol Kirandeep K. , Lange Mike , Olzmann James A. 
Published: September 2022

ABSTRACTThe bioactive sphingolipid ceramide impacts diverse cellular processes (e.g., apoptosis and cell proliferation) through its effects on membrane dynamics and intracellular signalling pathways. The dysregulation of ceramide metabolism has been implicated in cancer evasion of apoptosis and targeting ceramide metabolism has potential therapeutic benefits as a strategy to kill cancer cells and slow tumor growth. However, the mechanisms of cancer cell resistance to ceramide-mediated cell death are vastly intertwined and incompletely understood. To shed light on this mystery, we performed a genome wide CRISPR-Cas9 screen to systematically identify regulators of cancer resistance to the soluble short chain ceramide, C6 ceramide (C6-Cer). Our results reveal a complex landscape of genetic modifiers of C6-Cer toxicity, including genes associated with ceramide and sphingolipid metabolism, vesicular trafficking, and membrane biology. Furthermore, we find that loss of the phospholipid flippase subunit TMEM30A impairs the plasma membrane trafficking of its binding partner the P4-type ATPase ATP11B, and depletion of TMEM30A or ATP11B disrupts plasma membrane asymmetry and promotes resistance to C6-Cer toxicity independent of alterations in C6-Cer uptake. Together, our findings provide a resource of genetic modifiers of C6-Cer toxicity and reveal an unexpected role of plasma membrane asymmetry in C6-Cer induced cell death.
Sources of Stress and Coping Mechanisms: Experiences of Maternal Health Care Providers in Western Kenya
Authors: Getahun Monica , Oboke Edwina N , Ogolla Beryl A , Kinyua Joyceline , Ongeri Linnet , Sterling Mona , Oluoch Iscar , Lyndon Audrey , Afulani Patience A. 
Published: September 2022

AbstractThe dynamic and complex nature of care provision predisposes healthcare workers to stress, including physical, emotional, or psychological fatigue due to individual, interpersonal, or organizational factors. We conducted a convergent mixed-methods study with maternity providers to understand their sources of stress and coping mechanisms they adopt. Data were collected in Migori County in western Kenya utilizing quantitative surveys with n=101 maternity providers and in-depth interviews with a subset of n=31 providers. We conducted descriptive analyses for the quantitative data. For qualitative data, we conducted thematic analysis, where codes were deductively developed from interview guides, iteratively refined based on emergent data, and applied by a team of five researchers using Dedoose software. Code queries were then analysed to identify themes and organized using the socioecological (SE) framework. Providers reported stress due to high workloads (61%); lack of supplies (37%), poor salary (32%), attitudes of colleagues and superiors (25%), attitudes of patients (21%), and adverse outcomes (16%). Themes from the qualitative analysis mirrored the quantitative analysis with more detailed information on the factors contributing to each and how these sources of stress affect providers and patient outcomes. Coping mechanisms adopted by providers are captured under three themes: addressing stress by oneself, reaching out to others, and seeking help from a higher power. Findings underscore the need to address organizational, interpersonal, and individual level stressors. Strategies are needed to support staff retention, provide adequate resources and incentives for providers, and ultimately improve patient outcomes. Interventions should support and leverage the positive coping mechanisms identified.
Cardiac muscle-restricted partial loss of Nos1ap expression has limited impact on electro- and echo-cardiographic features
Authors: Smith Alexa , Auer Dallas , Johnson Morgan , Sanchez Ernesto , Ross Holly , Ward Christopher , Chakravarti Aravinda , Kapoor Ashish 
Published: September 2022

AbstractGenome-wide association studies (GWAS) of QT interval variation have identified common noncoding variants at the NOS1AP gene as the most common genetic regulators of trait variation in the general population. Invoking a cis-regulatory mechanistic hypothesis, we have reported identification of a functional enhancer variant underlying the GWAS signal that influenced human cardiac NOS1AP expression. Functional studies based on in vitro overexpression in murine cardiomyocytes and ex vivo knockdown in zebrafish embryonic hearts, by us and others, have demonstrated that NOS1AP expression levels can alter cellular electrophysiology. Here, to explore the role of NOS1AP in cardiac electrophysiology at an organismal level, we generated and characterized constitutive and heart muscle-restricted Nos1ap knockout mice to assess whether NOS1AP disruption alters the QT interval in vivo. Constitutive loss of Nos1ap led to genetic background-dependent variable lethality at or right before birth. Heart muscle-restricted Nos1ap knockouts generated using cardiac specific alpha-myosin heavy chain promoter-driven tamoxifen-inducible Cre resulted in tissue-level Nos1ap expression reduced by half. This partial loss of expression had no detectable effect on the QT interval, but led to a small yet significant reduction in the QRS interval. Given that challenges associated with defining the end of T wave on murine electrocardiogram can limit identification of subtle effects on QT interval, and that common noncoding NOS1AP variants are also associated with QRS interval, our findings support the role of NOS1AP in regulation of the cardiac electrical cycle.
Paley and Hardy's inequalities for the Fourier-Dunkl expansions
Authors: Elgarna Anis 
Published: September 2022

PurposePaley's and Hardy's inequality are proved on a Hardy-type space for the Fourier–Dunkl expansions based on a complete orthonormal system of Dunkl kernels generalizing the classical exponential system defining the classical Fourier series.Design/methodology/approachAlthough the difficulties related to the Dunkl settings, the techniques used by K. Sato were still efficient in this case to establish the inequalities which have expected similarities with the classical case, and Hardy and Paley theorems for the Fourier–Bessel expansions due to the fact that the Bessel transform is the even part of the Dunkl transform.FindingsPaley's inequality and Hardy's inequality are proved on a Hardy-type space for the Fourier–Dunkl expansions.Research limitations/implicationsThis work is a participation in extending the harmonic analysis associated with the Dunkl operators and it shows the utility of BMO spaces to establish some analytical results.Originality/valueDunkl theory is a generalization of Fourier analysis and special function theory related to root systems. Establishing Paley and Hardy's inequalities in these settings is a participation in extending the Dunkl harmonic analysis as it has many applications in mathematical physics and in the framework of vector valued extensions of multipliers.
Improved method for analysing the dynamic response of gear transmission systems
Authors: Li Xiaofeng , Liu Xiaoxue , Li Xiangwei , He Weidong , Guo Hanfei 
Published: September 2022

PurposeThe purpose of this paper is to propose an improved method which can shorten the calculation time and improve the calculation efficiency under the premise of ensuring the calculation accuracy for calculating the response of dynamic systems with periodic time-varying characteristics.Design/methodology/approachAn improved method is proposed based on Runge–Kutta method according to the composition characteristics of the state space matrix and the external load vector formed by the reduction of the dynamic equation of the periodic time-varying system. The recursive scheme of the holistic matrix of the system using the Runge–Kutta method is improved to be the sub-block matrix that is divided into the upper and lower parts to reduce the calculation steps and the occupied computer memory.FindingsThe calculation time consumption is reduced to a certain extent about 10–35% by changing the synthesis method of the time-varying matrix of the dynamics system, and the method proposed of paper consumes 43–75% less calculation time in total than the original Runge–Kutta method without affecting the calculation accuracy. When the ode45 command that implements the Runge–Kutta method in the MATLAB software used to solve the system dynamics equation include the time variable which cannot provide its specific analytic function form, so the time variable value corresponding to the solution time needs to be determined by the interpolation method, which causes the calculation efficiency of the ode45 command to be substantially reduced.Originality/valueThe proposed method can be applied to solve dynamic systems with periodic time-varying characteristics, and can consume less calculation time than the original Runge–Kutta method without affecting the calculation accuracy, especially the superiority of the improved method of this paper can be better demonstrated when the degree of freedom of the periodic time-varying dynamics system is greater.
Aerodynamic optimisation of civil aero-engine nacelles by dimensionality reduction and multi-fidelity techniques
Authors: Tejero Fernando , MacManus David , Hueso-Rebassa Josep , Sanchez-Moreno Francisco , Goulos Ioannis , Sheaf Christopher 
Published: September 2022

Purpose
Aerodynamic shape optimisation is complex because of the high dimensionality of the problem, the associated non-linearity and its large computational cost. These three aspects have an impact on the overall time of the design process. To overcome these challenges, this paper aims to develop a method for transonic aerodynamic design with dimensionality reduction and multifidelity techniques.

Design/methodology/approach
The developed methodology is used for the optimisation of an installed civil ultra-high bypass ratio aero-engine nacelle. As such, the effects of airframe-engine integration are considered during the optimisation routine. The active subspace method is applied to reduce the dimensionality of the problem from 32 to 2 design variables with a database compiled with Euler computational fluid dynamics (CFD) calculations. In the reduced dimensional space, a co-Kriging model is built to combine Euler lower-fidelity and Reynolds-averaged Navier stokes higher-fidelity CFD evaluations.

Findings
Relative to a baseline aero-engine nacelle derived from an isolated optimisation process, the proposed method yielded a non-axisymmetric nacelle configuration with an increment in net vehicle force of 0.65% of the nominal standard net thrust.

Originality/value
This work investigates the viability of CFD optimisation through a combination of dimensionality reduction and multifidelity method and demonstrates that the developed methodology enables the optimisation of complex aerodynamic problems.
Examination of customer relations management in banks in terms of strategic, technological and innovation capability
Authors: Özdemir Sümeyye , Sonmez Cakir Fatma , Adiguzel Zafer 
Published: September 2022

PurposeBanks are fiercely competitive among themselves, focused on satisfying and retaining customers through the extensive use of technology for service innovation and delivery. In this context, the study aims to understand the impact of customer relationship management (CRM) and innovation capability, including strategy and technology elements, on customer satisfaction and the financial performance of banks.Design/methodology/approachThe sample population of the study consists of bank employees. Analyzes were made using the SMARTPLS program, and within the scope of the study, data were collected from 272 bank employees.FindingsAs a result of the analyzes, it can be explained that the innovation capability coupled with the CRM strategy and related technology have positive effects on both financial performance and customer satisfaction.Research limitations/implicationsThe research was conducted in banks that have an important position in the service sector. In terms of location, the data was collected in Istanbul because the headquarters are in Istanbul. Therefore, these limitations should be taken into account in future studies.Originality/valueThe research is quite new and up-to-date in terms of examining CRM from a strategic and technological point of view, as well as examining innovation competency.
Is relationship marketing investments–customer gratitude–customer loyalty linkage influenced by contextual and individual moderators? An emerging economy perspective
Authors: Mittal Saurabh , Maity Moutusy 
Published: September 2022

Purpose
This paper aims to explore the moderating impact of four moderators, namely, retailer brand strength, customer’s perceived purchase regularity, gender and purchase channel (online and offline) on the relationship between relationship marketing investments (RMIs) and customer gratitude, and customer gratitude and customer loyalty. The context of research is the purchase of a high-involvement product by Indian customers.

Design/methodology/approach
This study adapts Huang RMIs-Gratitude-Loyalty model and empirically validates the associated hypotheses using structural equation modeling. Data is collected through the survey method.

Findings
The study (N = 385) results suggest a significant impact of preferential treatment and interpersonal communication investments on customer’s feeling of gratitude toward the retailer and, consequently, on loyalty. Purchase channel, gender and, to a lesser extent, customer perceived regularity each moderates the relationships between marketing investment and gratitude, and that between gratitude and loyalty; surprisingly, retailer brand is not a significant moderator.

Research limitations/implications
Future research can factor in the impact of loyalty program on the proposed relationships.

Practical implications
This research offers helpful guidelines for retailers, especially for those who currently have a multichannel presence and invest or plan to invest in relationship marketing to obtain benefits from customer loyalty.

Originality/value
This investigation explores not only the relevance of RMIs–gratitude–loyalty model in the Indian retail context but also the influence of moderating variables on the retailers’ efforts of gaining consumer loyalty.
Durable self-cleaning nano-titanium dioxide superhydrophilic coating with anti-fog property
Authors: Syafiq Amirul , Balakrishnan Vengadaesvaran , Rahim Nasrudin Abd. 
Published: September 2022

Purpose
This paper aims to design the nano-titanium dioxide (TiO2) coating system which has superhydrophilic property, self-cleaning mechanism and antifog property as well as strong adhesion on glass substrate.

Design/methodology/approach
Two hydrophilic materials have been used such as TiO2 nanoparticles as fillers and hydrophilic copolymer, Pluronic F-127 by using simple sol–gel approach. The prepared solution was applied onto glass through dip- and spray-coating techniques and then left for drying at ambient temperature.

Findings
The nano-TiO2 superhydrophilic coating has achieved the water contact angle of 4.9° ± 0.5°. The superhydrophilic coating showed great self-cleaning effect against concentrated syrup and methylene blue where thin layer of water washes the dirt contaminants away. The nano-TiO2 coating exhibits great antifog performance that maintains high transparency of around 89% when the coated glass is placed above hot-fog vapor for 10 min. The fog droplets were condensed into water film which allowed the transmission of light through the glass. The strong adhesion of coated glass shows no total failure at scratch profile when impacted with scratch load of 500, 800 and 1,200 mN.

Research limitations/implications
Findings will be useful in the development of self-cleaning superhydrophilic coating that is applicable on building glass and photovoltaic panel.

Practical implications
The developed nano-TiO2 coating is developed by the combination of hydrophilic organic copolymer–inorganic TiO2 network to achieve great superhydrophilic property, optimum self-cleaning ability and supreme antifog performance.

Social implications
The findings will be useful for residents in building glass window where the application will reduce dust accumulation and keep the glass clean for longer period.

Originality/value
The synthesis of nano-TiO2 superhydrophilic coating which can be sprayed on large glass panel and cured at ambient temperature.