bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of behaviour change interventions delivered by non-dental health workers in promoting children’s oral health: A systematic review and meta-analysis
Authors: Faisal Mehreen Riaz , Mishu Masuma Pervin , Jahangir Faisal , Younes Sabahat , Dogar Omara , Siddiqi Kamran , Torgerson David J. 
Published: January 2022

Objectives
Dental caries is the most common preventable childhood condition. Non-dental professionals and health workers are often well placed to support parents in adopting positive oral health behaviours for their children. The aim of this study was to determine the effectiveness of behaviour change interventions and their individual component behaviour change techniques (BCTs), that were delivered by non-dental professionals and health workers.

Methods
A systematic search of Ovid MEDLINE, PubMed, CINAHL, Cochrane Library, Web of Science, TRoPHI and PROQUEST from inception until March 2021 was conducted. Randomised controlled trials and quasi-experimental studies for improving oral health outcomes in children were included. Quality assessment was carried out using Cochrane Risk of Bias tool and ROBINS-I tool. Publication bias was assessed using funnel plots and Egger’s regression intercept. Effect sizes were estimated as standardised mean difference (SMD) and odds ratio/risk ratio for proportions. Meta-analyses were performed for studies reporting mean decayed, missing, filled surfaces (dmfs) and mean decayed, missing, filled, teeth (dmft) indices. Behaviour change technique coding was performed using behaviour change technique taxonomy v1 (BCTTv1).

Results
Out of the 9,101 records retrieved, 36 studies were included with 28 showing a significant effect either in clinical and/or behavioural/knowledge outcomes. Most studies (n = 21) were of poor methodological quality. The pooled SMD for caries experience showed statistically significant result for caries prevention at surface level -0.15 (95% CI -0.25, -0.04) and at the tooth level -0.24 (95% CI -0.42, -0.07). In 28 effective interventions, 27 individual BCTs were identified and the most frequently used were: “Instructions on how to perform the behaviour” and “Information about health consequences”.

Conclusion
There is low quality of evidence suggesting non-dental professionals and health workers may help improve oral health outcomes for children. To confirm these findings, further high-quality studies incorporating a variety of BCTs in their interventions for adoption of good oral health behaviours are needed.
Validity and reliability of resiliency measures trialled for the evaluation of a preventative Resilience-promoting social-emotional curriculum for remote Aboriginal school students
Authors: Robinson Gary , Lee Eunro , Leckning Bernard , Silburn Sven , Nagel Tricia , Midford Richard 
Published: January 2022

Purpose
We aimed to test the reliability and validity of two brief measures of resilience adopted for the evaluation of a preventative social-emotional curriculum implemented for Aboriginal middle school students from socially disadvantaged remote communities in Australia’s Northern Territory. The questionnaires chosen were intended to measure psychological resilience and socio-cultural resilience as complementary dimensions of the capacity to cope in circumstances of significant life stress and risk of self-harm.

Methods
Confirmatory factor analysis (CFA) was conducted to assess construct validity of the 10-item Connor-Davidson Resilience Scale (CD-RISC-10), a measure of psychological resilience, and the 12-item Child and Youth Resilience Measure (CYRM-12), a measure of socio-cultural resilience, with a sample of 520 students. Associations between resilience and psychological distress and emotional and behavioural difficulty were analysed in relation to life stressors to assess criterion validity of the scales.

Results
CFA provided support for the validity of the respective constructs. There was good fit for both scales. However, assessment of criterion validity of the scales suggested that the adapted measure of socio-cultural resilience (CYRM-12NT) showed higher reliability and a clearer indication of predictive validity than the measure of psychological resilience (CD-RISC-10).

Conclusions
The CYRM-12NT appears to be a more useful measure of resilience among Aboriginal youth exposed to significant life stress and disadvantage. However, both measures may require further development to enhance their validity and utility among potentially at-risk adolescents in socially, culturally and linguistically diverse remote Aboriginal communities.
Avaliação, Monitoramento e Melhoria da Qualidade na APS
Authors: Tomasi Elaine , Nedel Fúlvio Borges , Barbosa Allan Claudius  Queiroz 
Published: January 2022

Esta nota técnica se insere no conjunto de ações desenvolvidas pela Rede de Pesquisa em Atenção Primária à Saúde e apresenta sua posição sobre avaliação, monitoramento e melhoria da qualidade na APS. Em um contexto de grave crise sanitária que desnuda as dificuldades institucionais, financeiras e operativas de resposta à situação de saúde, situa o debate e traz proposições que fortalecem uma prática avaliativa como instrumento essencial para o aprimoramento e fortalecimento de ações que potencializam o papel da APS no contexto do SUS. Estas notas abordam: a avaliação no contexto da APS em uma perspectiva histórica e institucional que situa sua relevância na própria trajetória do SUS. A importância de compreender os conceitos, métricas e indicadores e apropriá-los ao debate qualificado no âmbito da APS. Uma posição para a Rede APS em termos de desafios e proposições, visando a uma APS mais forte que nunca.

Palavras-chave: APS, Avaliação, Monitoramento, Qualidade.

Abstract
This technical report is part of the set of actions developed by the Primary Health Care Research Network and presents its position on evaluation, monitoring and quality improvement in PHC. In a context of serious health crisis that exposes the institutional, financial and operational difficulties in responding to the health situation, it situates the debate and brings proposals that strengthen an evaluative practice as an essential instrument for the improvement and strengthening of actions that enhance the role of PHC in the context of the SUS. These notes address: the assessment in the context of PHC in a historical and institutional perspective that locates its relevance in the trajectory of the SUS. The importance of understanding the concepts, metrics and indicators and appropriating them to the qualified debate within the PHC. A position for the APS Network in terms of challenges and propositions, aiming for a stronger APS than ever.
Keywords: PHS, assessing, monitoring, quality.
Stability Analysis of Mathematical Modeling of Interaction between Target Cells and COVID-19 Infected Cells
Authors: Sugiyanto Sugiyanto , Hamid Mansoor Abdul , Adianta Alya , Jayanti Hanny Puspha , Luthfi Muhammad Ja'far 
Published: January 2022

The stability analysis in this mathematical model was related to the infection of the Coronavirus Disease 2019 (Covid-19). In this mathematical model there were two balance points, namely the point of balance free from Covid-19 and the one infected with Covid-19. The stability of the equilibrium point was influenced by all parameters, i.e. target cells die during each cycle, number of target cells at Â = 0, target cells infected during each cycle based on virion unit density, effective surface area of the network, the ratio of the number of virus particles to the number of virions, infected cells die during each cycle, the number of virus particles produced by each infected cell during each cycle, and virus particles die during each cycle. In the simulation model, immunity is divided into high, medium and low immunity. For high, moderate and low immunity, respectively, the highest number of target cells is in high, medium and low immunity, whereas for the number of infected cells and the number of Covid-19, it is in the opposite sequence of the number of target cells.
A Theological Engagement with the Science of Science Skepticism
Authors: Reeves Josh 
Published: January 2022

When Christians reject the claims of scientific experts, are they being irrational? Much of recent discussion in scholarly and popular media have discussed science denialism by conservative Christians, linking a low view of scientific expertise to the United States’ current political turmoil. This paper will focus on scientific explanations of science skepticism, asking whether there is anything unique to religious communities that make them vulnerable to misinformation.
Primary Erlotinib Resistance in a Patient with Non-Small Cell Lung Cancer Carrying Simultaneous Compound EGFR L718A, Q849H, and L858R Mutations
Authors: Mirtavoos-mahyari Hanifeh , Rismani Elham , Lotfabadi Alireza Sarkar , Dezfouli Azizollah Abbasi , Sheikhy Kambiz , Dezfuli Mojtaba Mokhber , Heshmatnia Jalal 
Published: January 2022

Abstract
Nowadays, mutations in the epidermal growth factor receptor (EGFR) kinase domain are studied in targeted therapy of non-small cell lung cancer (NSCLC) with EGFR tyrosine kinase inhibitors including gefitinib and erlotinib. The present study reports a rare case of a patient harboring three simultaneous EGFR mutations (L718A, Q849H, and L858R). The development of erlotinib resistance was detected in the subsequent treatment. Using a computational approach, the current study investigated the conformational changes of wild-type and mutant EGFR's kinase domains in the interaction with erlotinib. Their binding modes with erlotinib were elucidated during molecular dynamics simulation, where higher fluctuations were detected in the mutated forms of the EGFR tyrosine kinase domain. Prediction of stability and functional effect of mutations revealed that amino acidic substitutions have decreased the protein stability as well as the binding affinity to erlotinib. These results may be useful for a recommendation of EGFR mutational analysis for patients with NSCLC carcinoma.
Effect of moving stretching sheets on natural convection in partially heated square cavity filled with nanofluid
Authors: Kumar Anil , Rao Pentyala Srinivasa 
Published: January 2022

Abstract
This article deals with the heat transfer enhancement due to buoyancy force in a partially heated square enclosure filled with nanofluids. The model is developed to analyse the behaviour of nanofluids taking into account of volume fraction and stretching parameter, when square horizontal walls are moving in opposite directions to each other. Implicit alternate direct finite difference method has been used to solve the governing equations of vorticity, energy, and kinematics. Graphically investigated the effect of physical pertinent controlling parameters on the dimensionless velocity, streamlines, isothermal, and Nusselt number. The obtained numerical solution achieves the best configuration for Rayleigh number 103 ≤ Ra ≤ 105, stretching parameter 0 ≤ τ ≤ 2.5, and volume fraction 0 ≤ ϕ ≤ 0.2. It is found that the stretching parameter and direction of moving walls affect the fluid flow, flow strength, and heat transfer in the cavity.
GC-rich repeat expansions: associated disorders and mechanisms
Authors: Schröder Christopher , Horsthemke Bernhard , Depienne Christel 
Published: January 2022

Abstract
Noncoding repeat expansions are a well-known cause of genetic disorders mainly affecting the central nervous system. Missed by most standard technologies used in routine diagnosis, pathogenic noncoding repeat expansions have to be searched for using specific techniques such as repeat-primed PCR or specific bioinformatics tools applied to genome data, such as ExpansionHunter. In this review, we focus on GC-rich repeat expansions, which represent at least one third of all noncoding repeat expansions described so far. GC-rich expansions are mainly located in regulatory regions (promoter, 5′ untranslated region, first intron) of genes and can lead to either a toxic gain-of-function mediated by RNA toxicity and/or repeat-associated non-AUG (RAN) translation, or a loss-of-function of the associated gene, depending on their size and their methylation status. We herein review the clinical and molecular characteristics of disorders associated with these difficult-to-detect expansions.
The Retrieval-Related Anterior Shift Is Moderated by Age and Correlates with Memory Performance
Authors: Srokova Sabina , Hill Paul F. , Rugg Michael D. 
Published: January 2022

Recent research suggests that episodic memory is associated with systematic differences in the localization of neural activity observed during memory encoding and retrieval. The retrieval-related anterior shift is a phenomenon whereby the retrieval of a stimulus event (e.g., a scene image) is associated with a peak neural response which is localized more anteriorly than the response elicited when the stimulus is experienced directly. Here, we examine whether the magnitude of the anterior shift (i.e., the distance between encoding- and retrieval-related response peaks) is moderated by age, and also whether the shift is associated with memory performance. Younger and older human subjects of both sexes underwent fMRI as they completed encoding and retrieval tasks on word-face and word-scene pairs. We localized peak scene and face selectivity for each individual participant within the face-selective precuneus and in three scene-selective (parahippocampal place area [PPA], medial place area, occipital place area) ROIs. In line with recent findings, we identified an anterior shift in the PPA and occipital place area in both age groups and, in older adults only, in the medial place area and precuneus also. Of importance, the magnitude of the anterior shift was larger in older than in younger adults. The shift within the PPA exhibited an age-invariant across-participant negative correlation with source memory performance, such that a smaller displacement between encoding- and retrieval-related neural activity was associated with better performance. These findings provide novel insights into the functional significance of the anterior shift, especially in relation to memory decline in older age.SIGNIFICANCE STATEMENTCognitive aging is associated with reduced ability to retrieve precise details of previously experienced events. The retrieval-related anterior shift is a phenomenon in which category-selective cortical activity at retrieval is localized anterior to the peak activity at encoding. The shift is thought to reflect a bias at retrieval in favor of semantic and abstract information at the expense of low-level perceptual detail. Here, we report that the anterior shift is exaggerated in older relative to younger adults, and we demonstrate that a larger shift in the parahippocampal place area is associated with poorer memory performance. These findings suggest that the shift is sensitive to increasing age and that it is moderated by the quality and content of the retrieved episode.
Immune checkpoint inhibitors, endocrine adverse events, and outcomes of melanoma
Authors: Karhapää Hanna , Mäkelä Siru , Laurén Hanna , Jaakkola Marjut , Schalin-Jäntti Camilla , Hernberg Micaela 
Published: January 2022

Objective
Immune checkpoint inhibitors (ICI) can cause endocrine adverse events. However, endocrine AEs could be related to better treatment outcomes. Our aim was to investigate whether this holds true in a real-world setting of metastatic melanoma patients.

Design
A retrospective single-institution study.

Methods
We included 140 consecutive metastatic melanoma patients treated with ICI between January 2012 and May 2019. We assessed the endocrine toxicity and the best possible treatment outcomes from electronic patient records, including laboratory parameters and radiological images.

Results
Of the treated patients, 21 patients (15%) were treated with ipilimumab, 46 (33%) with nivolumab, 67 (48%) with pembrolizumab, and 6 (4%) with combination therapy (ipilimumab + nivolumab). Endocrine AEs appeared in 29% (41/140) patients. Three patients had two different endocrine AEs. Thyroid disorders were the most common: 26% (36/140), followed by hypophysitis: 4% (5/140). Three subjects (2%, 3/140) were diagnosed with autoimmune diabetes. Three patients had to terminate treatment due to endocrine toxicity. Radiological manifestations of endocrine AEs were found in 16 patients (39%, 16/41). Endocrine toxicity was associated with significantly better treatment outcomes. Median progression-free survival (8.1 months, range 5.1–11.1 months vs 2.7 months, range 2.4–3.0 months, P < 0.001), and median overall survival (47.5 months, range 15.5–79.5 months vs 23.7 months, range 15.3–32.1 months, P = 0.035) were longer for patients experiencing endocrine AEs.

Conclusions
The higher number of endocrine AEs suggest that regular laboratory monitoring aids in AE detection. Endocrine AEs in metastatic melanoma may correlate with better treatment outcomes.
Research of beta-radioactivity of certain medicinal plants of Dnipro area
Authors: Lisovets O. I. , Serchenko I. S. 
Published: January 2022

In the course of research conducted in the laboratory of radioecology of DNU, information was obtained on the beta-radioactivity of nine species of medicinal plants from two types of habitats – meadow biocenosis on the outskirts of the village. Kirovsky Dnipro region and a weed-meadow group near the town of Kamyanske, Dnipro area. Beta-radioactivity of the studied medicinal plants varied in the range from 1.18×10-5 Bq to 19.09×10-5 Bq at relatively clean habitats and from 18.35×10-5 Bq to 82.95×10-5 Bq on the anthropogenically polluted area. In a relatively clean habitat, the lowest indicators of beta-radioactivity in aboveground organs are characterized by Artemisia vulgaris L. and Capsella bursa-pastoris (L.) Medikus, the highest – Hypericum perforatum L. and Achillea submillefolium Klokov & Krytzka. In the underground organs, the highest indicators of beta-radioactivity were recorded in Artemisia vulgaris and Hypericum perforatum, the lowest – in Melissa officinalis L. and Valeriana officinalis L. Under conditions of industrial pollution, the lowest indicators of beta-radioactivity in aboveground organs were found in Artemisia vulgaris and Matricaria recutita L., in underground – in Tanacetum vulgare L. and Achillea submillefolium. The highest values of beta-radioactivity in these conditions were registered in the aboveground organs of Tanacetum vulgare and Hypericum perforatum and in the underground parts of Melissa officinalis and Hypericum perforatum. The analysis showed that the anthropogenic factor (pollution) has a statistically proven effect on the beta-radioactivity of the studied medicinal plants (with a probability of P = 0.999). Indicators of the strength of influence were high – from 67 to 85%. Anthropogenic pollution has the greatest impact on the beta-radioactivity of underground organs. The identified trend reflects a well-known natural dependence – the farther along the transport chain from the root is the body, the less, as a rule, it accumulates radionuclides. The detected values of beta-radioactivity, including in the industrially contaminated area are not dangerous with a single use of the studied medicinal plants. However, medicinal plants collected in the contaminated area due to increased beta-radioactivity can cause damage with prolonged systematic use due to the cumulative effect and are therefore not recommended for use.
Calidad microbiológica y fisicoquímica y sabor de huevos de gallina de producción convencional o pastoreo
Authors: Guier-Serrano Marie , Davidovich-Young Gabriela , Wong-González Eric , Cubero-Castillo Elba 
Published: January 2022

Introducción. El huevo de gallina (Gallus gallus domesticus) es un alimento nutritivo de la dieta de millones de personas. Su producción mundial se obtiene con el empleo de jaulas convencionales, aunque existen sistemas alternativos como el pastoreo. Objetivo. Comparar la calidad microbiológica, fisicoquímica y el sabor de huevos provenientes de granjas con sistemas productivos convencionales o de pastoreo en Costa Rica. Materiales y métodos. El trabajo se realizó en Alajuela, Costa Rica de octubre del 2016 a mayo del 2017. Se muestrearon superficies y huevos de gallinas Isa Brown en granjas con sistemas productivos convencionales o de pastoreo y se determinó el recuento de coliformes totales, Escherichia coli, mohos y levaduras y ausencia/presencia de Salmonella sp. Además, se analizaron parámetros fisicoquímicos (unidades Haugh, índice de yema, pH, color de yema y dureza de cáscara) y se realizó una prueba sensorial de discriminación con consumidores. Resultados. Los sistemas de producción de pastoreo tienen superficies en contacto con los huevos con recuentos de coliformes totales y E. coli significativamente mayores que las superficies del sistema convencional. Los huevos de pastoreo presentaron recuentos de coliformes totales (3,2 log10 UFC huevo-1) significativamente mayores que los huevos convencionales (2,3 log10 UFC huevo-1). Salmonella sp. estuvo presente en 8 % de las muestras de pastoreo (incidencia no diferente de 0) y ausente en las convencionales. Se encontró diferencia en el color de la yema (más oscura en los huevos convencionales). Además, hubo diferencia significativa en el sabor de ambos tipos de huevo. Conclusión. En general, existió diferencia en la calidad microbiológica, fisicoquímica y el sabor de huevos producidos en granja de tipo convencional o pastoreo.
On $n$-absorbing prime ideals of commutative rings
Authors: ISSOUAL Mohammed , MAHDOU Najib , ABDOU SALAM MOUTUİ Moutu 
Published: January 2022

This paper investigates the class of rings in which every nn-absorbing ideal is a prime ideal, called nn-AB ring, where nn is a positive integer. We give a characterization of an nn-AB ring. Next, for a ring RR, we study the concept of Ω(R)={ωR(I);I is a proper ideal of R},Ω(R)={ωR(I);I is a proper ideal of R}, where ωR(I)=min{n;I is an n-absorbing ideal of R}ωR(I)=min{n;I is an n-absorbing ideal of R}. We show that if RR is an Artinian ring or a Prüfer domain, then Ω(R)∩NΩ(R)∩N does not have any gaps (i.e., whenever n∈Ω(R)n∈Ω(R) is a positive integer, then every positive integer below nn is also in Ω(R)Ω(R)). Furthermore, we investigate rings which satisfy property (**) (i.e., rings RR such that for each proper ideal II of RR with ωR(I)&lt;∞ωR(I)&lt;∞, $\omega_{R}(I)=\mid Min_R(I)\mid $ωR(I)=∣MinR(I)∣, where MinR(I)MinR(I) denotes the set of prime ideals of RR minimal over II). We present several properties of rings that satisfy condition (**). We prove that some open conjectures which concern nn-absorbing ideals are partially true for rings which satisfy condition (**). We apply the obtained results to trivial ring extensions.
Federated learning‐powered visual object detection for safety monitoring
Authors: Liu Yang , Huang Anbu , Luo Yun , Huang He , Liu Youzhi , Chen Yuanyuan , Feng Lican , Chen Tianjian , Yu Han , Yang Qiang 
Published: January 2022

AbstractVisual object detection is an important artificial intelligence (AI) technique for safety monitoring applications. Current approaches for building visual object detection models require large and well‐labeled dataset stored by a centralized entity. This not only poses privacy concerns under the General Data Protection Regulation (GDPR), but also incurs large transmission and storage overhead. Federated learning (FL) is a promising machine learning paradigm to address these challenges. In this paper, we report on FedVision—a machine learning engineering platform to support the development of federated learning powered computer vision applications—to bridge this important gap. The platform has been deployed through collaboration between WeBank and Extreme Vision to help customers develop computer vision‐based safety monitoring solutions in smart city applications. Through actual usage, it has demonstrated significant efficiency improvement and cost reduction while fulfilling privacy‐preservation requirements (e.g., reducing communication overhead for one company by 50 fold and saving close to 40,000RMB of network cost per annum). To the best of our knowledge, this is the first practical application of FL in computer vision‐based tasks.