bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic sclerosis and tachycardia–bradycardia syndrome: a case report
Authors: Faraj Raid , Laktib Nabil , Hilal Safae , Hassan Fadoun , Krimech Amine , Bouanani Alaa , Sarsari Mohamed , Fellat Ibtissam , Zarzur Jamila , Cherti Mohamed 
Published: June 2022

Abstract
Background
Systemic sclerosis is a multisystemic character autoimmune disease. It is characterized by vascular dysfunction and progressive fibrosis affecting mainly the skin but also different internal organs. All heart structures are commonly affected, including the pericardium, myocardium, and conduction system. However, tachycardia–bradycardia syndrome is not common in the literature as a cardiac complication of systemic sclerosis.
Case presentation
We report a case of tachycardia–bradycardia syndrome in a 46-year-old Moroccan woman followed for systemic sclerosis with cutaneous, vascular, and articular manifestations. The diagnosis was based mainly on patient-reported symptoms and electrocardiogram data. A permanent pacemaker was implanted, allowing the introduction of beta-blockers with good outcomes.

Conclusions
This case aims to show that even minor electrocardiogram abnormalities should be monitored in this group of patients, preferably by 24-hour ambulatory electrocardiogram because they could be a good indicator of the activity and progression of cardiac fibrosis.
Vascular anomaly diagnosis by central venous catheter misplacement: a case report
Authors: de Smalen Peter Paul , Stoutjesdijk Mark Jeroen 
Published: June 2022

Abstract
Background
Congenital heart diseases rarely have a primary manifestation in adulthood. They are a rare cause of pulmonary hypertension in adults.

Case presentation
A 70-year-old woman of Eurasian descent underwent emergency surgery for bowel ischemia. Her history of mild pulmonary hypertension likely correlates with a peculiar diagnosis of an anatomic anomaly on the postoperative x-ray and computed tomography scan. The central venous catheter was misplaced. Initial management consisted of removal of the catheter. The diagnosis, partial anomalous pulmonary venous return, may pose a clinical therapeutic dilemma.

Conclusions
Partial anomalous pulmonary venous return is a potentially treatable cause of pulmonary hypertension. With the current trend toward more medical imaging, we expect this diagnosis to be made more often in the future.
Signal design and processing for noise radar
Authors: Galati Gaspare , Pavan Gabriele , Wasserzier Christoph 
Published: June 2022

AbstractAn efficient and secure use of the electromagnetic spectrum by different telecommunications and radar systems represents, today, a focal research point, as the coexistence of different radio-frequency sources at the same time and in the same frequency band requires the solution of a non-trivial interference problem. Normally, this is addressed with diversity in frequency, space, time, polarization, or code. In some radar applications, a secure use of the spectrum calls for the design of a set of transmitted waveforms highly resilient to interception and exploitation, i.e., with low probability of intercept/exploitation capability. In this frame, the noise radar technology (NRT) transmits noise-like waveforms and uses correlation processing of radar echoes for their optimal reception. After a review of the NRT as developed in the last decades, the aim of this paper is to show that NRT can represent a valid solution to the aforesaid problems.
Toward energy saving and food safety in Central Mozambique: the role of improved cook stoves and heat retention boxes
Authors: Matavel Custodio E. , Hafner Johannes M. , Hoffmann Harry , Uckert Götz , Massuque Jonas , Rybak Constance , Sieber Stefan 
Published: June 2022

Abstract
Background
Almost 80% of the population in sub-Saharan Africa relies on traditional biomass for cooking, which is typically associated with negative environmental, health, economic, and social impacts. Thus, many stakeholders, including development agencies and national governments in the Global South are promoting the use of the improved cookstove in order to save cooking time, save financial assets, maximize fuel efficiency, and reduce indoor air pollution. However, little attention is paid to the heating practices among households, which can determine food safety levels. Specifically, cooked food should be kept at temperatures above the danger zone (from 5 to 57 °C) prior to its consumption to prevent its contamination by bacteria and other unhealthy contaminants. In general, many studies address food preparation and storage separately, despite being complementary. In this study, we attempt to understand whether, the use of improved cookstove combined with heat retention box would result in improvements with regard to fuel and time saving, and adequate food storage temperatures. Furthermore, we examine the acceptability of food prepared with these two systems based on consumers’ preference analysis. Involving 122 participants, the study was conducted in Gurué district, central Mozambique.

Results
The use of improved cookstove resulted in energy savings of 9% and 17% for cooking maize porridge and beans curry, respectively. The overall time consumption for cooking decreased by 14% (beans curry) and 24% (maize porridge). The use of heat retention boxes shows a better heat retention ability as compared to the locally used heat retention systems (leftovers, banana leaves).

Conclusions
The study concludes that improved cookstove is a sustainable mean for saving cooking time and fuel. Heat retention box has a potential to maintain adequate food storage temperatures. Both improved cookstove and heat retention box present a superior performance compared to traditional technologies; thus, can easily be diffused for not affecting the quality of food.
Effect of Lonicera edulis polysaccharide on reducing oral dyeing of lonicera edulis juice
Authors: Wang Xin , Luo Yu , Ma Rui , Wang Zhili , Yu Shiyou , Li Chenchen , Han Chunran 
Published: June 2022

AbstractFluorescence spectroscopy, particle size determination, and potential analysis were exploited to elucidate the effect of Lonicera edulis polysaccharide on polyphenol protein. The results revealed that Lonicera edulis polysaccharides mediated the binding of polyphenols and proteins through competition and formation of ternary complexes and were also able to enhance the stability of the polyphenol-protein complex solution system. A certain electrostatic effect was also present in the process simultaneously. As confirmed by the dyeing test, to improve oral dyeing, the optimum conditions of adding polysaccharide, pectin, and casein were as follows: the dosage of the polysaccharide group was 1.2 mg/mL, coloring time was 100 min, pH value was 4.0. Pectin group added 0.8 mg/mL with coloring time 80 min, pH 5.0. The addition of casein was 1.2 mg/mL; the coloring time was 100 min with pH 5.0. The sample juice substantiated a significant improvement in the dyeing of porcine tongue mucosa. Under the optimal conditions, microscopic observation validates that the mucosal color of the porcine tongue epidermis was closer to that of unstained porcine tongue epidermis, which significantly improved astringency and oral staining.
Changes in the BTK/NF-κB signaling pathway and related cytokines in different stages of neuromyelitis optica spectrum disorders
Authors: Qiao Huimin , Mao Zhuofeng , Wang Wei , Chen Xin , Wang Suhuan , Fan Haolong , Zhao Tianyi , Hou Huiqing , Dong Mei 
Published: June 2022

Abstract
Objective
Neuromyelitis optica spectrum disorders (NMOSDs) are blindness-causing neuritis; their pathogenesis is still not fully elucidated. Although it has been determined that Bruton tyrosine kinase (BTK) and NF-κB are associated with NMOSD, the changes that occur in different periods remain unknown. The study aimed to demonstrate the changes in the BTK/NF-κB pathway and related chemokines in different stages of NMOSDs.

Methods
A total of 32 patients with NMOSD were selected as the experimental group, and 32 healthy volunteers were included in the control group. In this study, the BTK/NF-κB pathway and related chemokines in the cerebrospinal fluid and peripheral blood samples of patients with NMOSD were analyzed in the acute or remission phase.

Results
BTK, NF-κB, PI3K, IKK, CXCL2, and CXCL12 levels in the NMOSD group in the acute or remission phase were significantly higher than those in the control group (p < 0.05).

Conclusion
The BTK/NF-κB pathway plays a vital role in the progression of NMOSD pathology. Our results shed light on its important role as a therapeutic target for NMOSD.
Reproductive performance and functional response of Eretmocerus mundus Mercet (Hymenoptera: Aphelinidae) obtained from cold-stored red-eyed pupae
Authors: Keser Berivan , Karaca Mahmut Mete , Karut Kamil 
Published: June 2022

AbstractBackgroundCold storage of reared natural enemies is important in terms of planning the release time and quantity, eliminating unpredicted demand increases, and reducing production costs. However, the tolerance of reared natural enemies at low temperatures varies depending on the species and needs to be determined.Eretmocerus mundusMercet (Hymenoptera: Aphelinidae) is one of the most important natural enemies used in biological control ofBemisia tabaci(Gennadius) (Hemiptera: Aleyrodidae) in greenhouses.ResultsIn a laboratory study, longevity, parasitism capacity and functional response ofE. mundusadults obtained from 8-days cold-stored red-eyedE.munduspupae at 10 °C with 45 ± 5% RH conditions were determined. Mean longevity obtained from storedE.munduspupae of female and male were 23.6 and 16.2 days, respectively. However, parasitism capacity was negatively affected so that the total mean number of immatureB.tabaciparasitized by anE.mundusfemale obtained from cold-stored pupae (13.6) was statistically lower than that obtained from the colony (26.8) reared at room temperature. Adults obtained from both non-stored and storedE.munduspupae exhibited a type II functional response to increasing host density. Although cold storage did not alter the type of functional response, it negatively affected the maximum attack rate (α) and handling time (Th) of the parasitoid. The lowest maximum attack rate (1.56) and highest handling time (0.059) were obtained for adults of cold-storedE.munduspupae.ConclusionsThe results obtained may contribute to the augmentative biological control ofB. tabaciin greenhouses.
Sparus aurata and Lates calcarifer skin microbiota under healthy and diseased conditions in UV and non-UV treated water
Authors: Al-Ashhab Ashraf , Alexander-Shani Rivka , Avrahami Yosef , Ehrlich Roberto , Strem Rosa Ines , Meshner Shiri , Shental Noam , Sharon Galit 
Published: June 2022

Abstract
Background
The welfare of farmed fish is influenced by numerous environmental and management factors. Fish skin is an important site for immunity and a major route by which infections are acquired. The objective of this study was to characterize bacterial composition variability on skin of healthy, diseased, and recovered Gilthead Seabream (Sparus aurata) and Barramundi (Lates calcarifer). S. aurata, which are highly sensitive to gram-negative bacteria, were challenged with Vibrio harveyi. In addition, and to provide a wider range of infections, both fish species (S. aurata and L. calcarifer) were infected with gram-positive Streptococcus iniae, to compare the response of the highly sensitive L. calcarifer to that of the more resistant S. aurata. All experiments also compared microbial communities found on skin of fish reared in UV (a general practice used in aquaculture) and non-UV treated water tanks.

Results
Skin swab samples were taken from different areas of the fish (lateral lines, abdomen and gills) prior to controlled infection, and 24, 48 and 72 h, 5 days, one week and one-month post-infection. Fish skin microbial communities were determined using Illumina iSeq100 16S rDNA for bacterial sequencing. The results showed that naturally present bacterial composition is similar on all sampled fish skin sites prior to infection, but the controlled infections (T1 24 h post infection) altered the bacterial communities found on fish skin. Moreover, when the naturally occurring skin microbiota did not quickly recover, fish mortality was common following T1 (24 h post infection). We further confirmed the differences in bacterial communities found on skin and in the water of fish reared in non-UV and UV treated water under healthy and diseased conditions.

Conclusions
Our experimental findings shed light on the fish skin microbiota in relation to fish survival (in diseased and healthy conditions). The results can be harnessed to provide management tools for commercial fish farmers; predicting and preventing fish diseases can increase fish health, welfare, and enhance commercial fish yields.
Time-honored praxis in preparing smoked meat delicacy (kinuday) of the ibaloy indigenous people in Benguet, Philippines
Authors: Garambas Cynthia D. , Luna Myrna Benita Z. , Chua Consuelo T. 
Published: June 2022

AbstractEvery culture protects its indigenous knowledge and practices, distinguishing them from other cultures. A qualitative inquiry described the traditional processing methods in preparing smoked meat or kinuday, produced by the Ibaloy Indigenous Ethnic group in the Philippines. The saturation method was used to determine data sufficiency. Fifteen participants from the two Ibaloy-speaking municipalities of Benguet, Philippines served as the key informants for the study. Results show that Benguet native pork and rock salt are the usual raw materials for kinuday. Additionally, branches and trunks from locally available trees are utilized as smoking materials. Traditionally, meat is smoked on top of the cooking area called so-olan for one day, continuous to one month intermittent until fully consumed. Kinuday is attributed to the festivities performed by the Ibaloy IP group and the availability of the elements in producing the traditional food is the primary factor for continuing the practice. To ensure preservation and cultural transmission of traditional kinuday preparation practices, it is recommended that a formal documentary be developed and disseminated to various stakeholders.
A survey of laxoox/canjeero, a traditional Somali flatbread: production styles
Authors: Wolgamuth Erin , Yusuf Salwa , Hussein Ali , Pasqualone Antonella 
Published: June 2022

AbstractFlatbreads are traditional food products of ancient origin, still produced and appreciated in their original locations and beyond, having spread through historical and modern migration. While the history and preparation of Somali flatbread, known ascanjeeroin southern regions andlaxooxin northern regions, has been shared orally for generations among the women who cook it at home, it has not been the object of scientific studies. An in-field study was therefore carried out in various cities in Somalia, Somaliland, and Ethiopia’s Somali State to document the formulation, production methods, and consumption patterns of this Somali flatbread.Laxoox/canjeeroproduction was found to be relatively homogenous, but the data revealed two significant divergences: in bread formulation and in the procedure for structure development. These divergences result from disparities in the mechanization of bread production between rural and urban, and from the destruction of infrastructure, including food processing machines in public markets, leading up to the Somali civil war. An original framework of four production styles (“heritage,” “new heritage,” “innovative,” and “global”) illustrates these divergences in detail. Heritage production is linked to the historic era of nomadic Somali pastoralism, while the other three styles originated in civil conflict and continue today.Graphical abstract
An implementation research programme to support an intravenous iron intervention for pregnant women with moderate and severe anaemia in Malawi: study protocol
Authors: Prang Khic-Houy , Mamani-Mategula Elisabeth , Verbunt Ebony , Chipeta Effie , Ataide Ricardo , Mwangi Martin , Phiri Kamija , Pasricha Sant-Rayn , Kelaher Margaret , Manda-Taylor Lucinda 
Published: June 2022

Abstract
Background
Antenatal iron supplementation is critical to maternal and child health; however, access and adherence to oral iron are inconsistent in many low- and middle-income countries (LMICs). Modern intravenous (IV) iron products have become available in high-income clinical settings and provide an opportunity to deliver high doses of iron in a single-short infusion during pregnancy. However, there is limited knowledge of the drivers and barriers for such an intervention to be effectively delivered and upscaled in LMICs. In this study protocol, we describe the implementation research programme to support an IV iron intervention in Malawi for pregnant women with moderate and severe anaemia.

Methods
The implementation research programme has three phases, each guided by implementation science conceptual frameworks. In Phase 1, we will conduct formative research (context assessment of the health system with key informant interviews) to determine how IV iron can be effectively introduced into routine antenatal care. We will use the findings to co-develop potential strategies with end-users and healthcare providers to improve intervention implementation. In Phase 2, we will disseminate the implementation strategies to support the uptake and delivery of the intervention in the study settings. In Phase 3, the intervention will be implemented, and we will conduct formative evaluation (interviews with end-users, healthcare providers, and analysis of health services data) to investigate the feasibility and acceptability of the intervention and strategies. We will also identify processes and contextual factors that facilitate or impede the delivery and uptake of IV iron.

Discussion
In LMICs, modern IV iron products present a novel opportunity to rapidly cure moderate and severe anaemia in pregnancy, thereby improving maternal and child health outcomes. This implementation research programme will provide guidance and recommendations on how best an IV iron intervention for pregnant women with anaemia can be implemented in an LMIC setting like Malawi. We will develop locally relevant and culturally appropriate implementation strategies by engaging with key stakeholders (pregnant women, healthcare providers, and policymakers) and identifying factors likely to facilitate successful implementation. The findings of this research can guide the implementation of an IV iron intervention in Malawi and other LMICs.
Interference in a Neutralizing Antibody Assay for Odronextamab, a CD20xCD3 Bispecific mAb, from Prior Rituximab Therapy and Possible Mitigation Strategy
Authors: Irvin Susan C. , D’Orvilliers Amanda , Bloch Nicolin , Boccio Kayla , Pennucci Jason , Brouwer-Visser Jurriaan , Ullman Erica , Rajadhyaksha Manoj , Hassanein Mohamed , Potocky Terra , Torri Albert , Hermann Aynur , Partridge Michael A. 
Published: June 2022

AbstractA cell-based assay was developed to detect neutralizing anti-drug antibodies (NAbs) against odronextamab, a CD20xCD3 bispecific monoclonal antibody (mAb) under investigation for treatment of CD20+ B cell malignancies. In this assay, odronextamab bridges between two cell types, CD20-expressing HEK293 cells and CD3-expressing Jurkat T cells that generate a luciferase signal upon CD3 clustering. Patient samples containing NAbs directed to either arm of the bispecific drug block the odronextamab bridge formation between the cell lines thus preventing the generation of the luciferase signal. We determined that other anti-CD20 therapeutics also block bridge formation, resulting in false-positive results. In patient samples from odronextamab clinical trials, approximately 30% of baseline samples had a strong false-positive NAb signal that correlated with the presence of prior rituximab (anti-CD20) therapy. We determined that rituximab interference can be minimized by the addition of anti-rituximab antibodies in the NAb assay. Understanding and mitigating the impact of prior biologic exposure is increasingly important for implementing a successful bioanalytical strategy to support clinical drug development, especially in the immuno-oncology field.
Graphical Abstract
Odronextamab neutralizing antibody assay, interference, and mitigation. A Design of the odronextamab neutralizing antibody (NAb) assay where anti-CD20xCD3 drug bridges between CD20-expressing HEK293 cells and Jurkat T cells expressing an NFAT response element and luciferase reporter. True NAb prevents odronextamab from bridging between target and effector cells, thus preventing the expression of luciferase. B Interference with odronextamab from other anti-CD20 therapeutic antibodies (e.g., rituximab) from prior disease treatment generates a false-positive NAb result. Assay interference can be mitigated with an anti-idiotypic antibody against the interfering therapy.
Dissipative solitons in magnetized anisotropic plasma
Authors: Khalid Muhammad , Khan Hayat 
Published: June 2022

Abstract
The propagation of ion-acoustic (IA) dissipative solitons (DSs) is investigated in magnetized plasma with the presence of pressure anisotropy and Maxwellian distributed electrons. A nonlinear damped Korteweg-de Vries (d-KdV) type equation is derived for the potential by employing the reductive perturbation method (RPM) and its dissipative soliton solution is analyzed. The effect of plasma parameters like parallel anisotropic ion pressure p
1, perpendicular anisotropic ion pressure p
2, obliqueness l
3, ion-neutral collisional parameter γ and magnetic field strength Ω on the characteristics of DSs are investigated. The present investigation could be useful in space and astrophysical plasma systems.