bluuebunny/crossref_metadata_2025_split huggingface dataset:
Massive ossification of the right patella and surrounding soft tissue caused by open trauma and its treatment: case report
Authors: Aikebaier Aobulikasimu , Jiang Luoyong , Yue Jiajie , You Wei , Sun Weichao , Yang Peng , Xie Wei , Zhai Rihong , Sun Wei 
Published: August 2022

Abstract
Heterotopic ossification (HO) refers to the presence of new bone in soft tissue. It occurs mostly around large joints, such as the hip and elbow, but it is rare in the patella and patellar ligaments. It is common in patients with nerve paralysis. In this article, we describe a rare case of Massive ossification of the right patella and surrounding soft tissue, mainly caused by open trauma, and describe its treatment.Case presentation:The 41-year-old male patient had a history of repeated pain and limited mobility of the right knee joint beginning 5 years previously, as well as severe limitation of mobility of the right knee joint during the previous year. The results of the auxiliary examination on admission were as follows: X-ray examination results showed degenerative changes in the right knee joint, an unequal length of lower limbs, and a tilted pelvis. Computed tomography (CT) examination revealed extensive tendon calcification and joint degeneration in the right knee. Magnetic resonance imaging (MRI) of the right knee revealed degenerative changes of the right knee, which was considered to be caused by extensive tendon ossification of the right knee, grade 2–3 damage to the lateral meniscus in the right knee, an obvious medial posterior horn, and a small amount of fluid accumulation in the cavity and joint capsule of the right knee. The patient had no other bone or joint diseases, chronic diseases, or family history of such diseases.The patient underwent a total joint replacement operation under general anesthesia and experienced immediate pain relief and full restoration of knee range of motion.Conclusion:This is the first report of extensive ossification of the patella and surrounding tissues resulting in knee pain and limited knee mobility. Based on the literature review, this case describes the difference between patella ossification and calcification and related factors leading to patella ossification. The case showed a good prognosis after surgical treatment.
Control direct laser cooling scheme by the optimized electric field
Authors: Yan Niu-Zao , Yang Chuan-Lu Yang , Wang Meishan , Ma Xiao-Guang 
Published: August 2022

Abstract
A method for manipulating molecules without suitable electronic properties to be viable candidates for laser cooling is described. Only a few natural molecules have a highly diagonal Franck–Condon factor (FCF) for the laser cooling scheme. Thus, we manipulate the FCFs by using an electric field identified by an optimized method based on linear regression. The details and the validity of the method are demonstrated using the CsH molecule. The different angles between the electric field and the molecular axis are considered, and the potential energy surfaces dependent on the electric field and angle are constructed. The vibrational energies and FCFs dependent on the angles are obtained, and the corresponding laser cooling schemes relative to the angles are built, which induce the accumulated FCFs of each scheme to exceed 0.999. The schemes can exert work at the angle between the molecular axis and the electric field is 1080° with five pumping lasers with center wavelengths of 473.74, 499.58, 527.72, 540.22, and 571.62 nm. In principle, the present method can be extended to any diatomic molecules without highly diagonal FCFs under natural conditions, providing a theoretical basis for studying physical and chemical problems involving cold molecules.
H172Y mutation perturbs the S1 pocket and nirmatrelvir binding of SARS-CoV-2 main protease through a nonnative hydrogen bond
Authors: de Oliveira Vinicius , Ibrahim Mohamed , Sun Xinyuanyuan , Hilgenfeld Rolf , Shen Jana 
Published: August 2022

Abstract
Nirmatrelvir is an orally available inhibitor of SARS-CoV-2 main protease (Mpro) and the main ingredient of PAXLOVID, a drug approved by FDA for high-risk COVID- 19 patients. Although the prevalent Mpro mutants in the SARS-CoV-2 Variants of Concern (e.g., Omicron) are still susceptible to nirmatrelvir, a rare mutation, H172Y, was found to significantly reduce nirmatrelvir’s inhibitory activity. As the selective pres- sure of antiviral therapy may favor resistance mutations, there is an urgent need to understand the effect of H172Y mutation on Mpro’s structure, function, and drug re- sistance. Here we report the molecular dynamics (MD) simulations as well as the measurements of stability, enzyme kinetics of H172Y Mpro, and IC50 value of nir- matrelvir. Simulations showed that mutation disrupts the interactions between the S1 pocket and N terminus of the opposite protomer. Intriguingly, a native hydrogen bond (H-bond) between Phe140 and the N terminus is replaced by a transient H- bond between Phe140 and Tyr172. In the ligand-free simulations, strengthening of this nonnative H-bond is correlated with disruption of the conserved aromatic stacking between Phe140 and His163, leading to a partial collapse of the oxyanion loop. In the nirmatrelvir-bound simulations, the nonnative H-bond is correlated with the loss of an important H-bond between Glu166 and nirmatrelvir’s lactam nitrogen at P1 position. These results are consistent with the newly reported X-ray structures of H172Y Mpro and suggest a mechanism by which the H172Y substitution perturbs the S1 pocket, leading to the decreased structural stability and binding affinity, which in turns explains the drastic reduction in catalytic activity and antiviral susceptibility.
Mir-4699 Promotes the Osteogenic Differentiation of Mesenchymal Stem Cells
Authors: Hosseini Vahedeh , Paryan Mahdi , Koochaki Ameneh , Cesaire Henry Manuel , Mohammadi-Yeganeh Samira 
Published: August 2022

Abstract
Mesenchymal stem cells (MSCs) are drawing considerable attention in the field of regenerative medicine due to their differentiation capabilities. The miRNAs are among the most important epigenetic regulators of MSC differentiation. Our previous study identified miR-4699 as a direct suppressor of the DKK1 and TNSF11 genes expression. However, the precise osteogenic-related phenotype or mechanism caused by miR-4699 change has yet to be dealt with in depth. In the present study, miR-4699 mimics were transfected into Adipose tissue-derived mesenchymal stem cells (AdMSCs) and osteoblast marker genes expression were analyzed to investigate whether that miR-4699 promotes osteoblast differentiation of hAd-MSCs through targeting the DKK-1 and TNFSF11. We further examined and compared the effects of recombinant human BMP2 with miR-4699 on cell differentiation. In addition to quantitative PCR, analyses of alkaline phosphatase activity and Alizarin red staining were used to explore osteogenic differentiation. The overexpression of miR-4699 in hA-MSCs resulted in the stimulation of alkaline phosphatase activity, osteoblast mineralization, and the expression of ALP and OCN osteoblast marker genes. Our findings indicated that miR-4699 supported and synergized the BMP2-induced osteoblast differentiation of mesenchymal stem cells. We suggest, thereof, the utilization of hsa-miR-4699 for further in vivo experimental investigation to reveal the potential therapeutic impact upon regenerative medicine for different types of bone defects.
Phase transformation and deformation of the high frequency induction brazed grinding wheel based on multi-field coupling
Authors: Li Qilin , Wang Xichao , Hou Chaopeng , Ding Kai , Ren Weibin , Han Jinjin , Lei Weining 
Published: August 2022

Abstract
With the characteristic of the high bonding strength to matrix, good sharpness and large chip-storage spaces, the brazed super abrasive grinding wheels have superiorities in the machining of difficult-to-machine materials. However, thermal deformation is caused by the high temperature during the brazing process, leading the accuracy of the brazed grinding wheel degraded greatly. By means of local heating, high frequency induction brazing can reduce the thermal deformation of the wheel. Aiming at the thermal deformation mechanism of the induction brazed wheel, a numerical simulation model of thermal-stress-phase multi-field coupling was established considering the temperature dependent physical properties of the material. The simulation result indicated that the phase transformation occurred near the work surface of the wheel substrate. The depth of phase transformation layer decreased from 6.0 mm to 2.9 mm with the scanning speed increasing from 0.5 mm/s to 2.0 mm/s. Microstructure of the phase transformation layer mainly consisted of ferrite, pearliten and bainite after brazing. An appropriate scanning speed was more important for the high accuracy of the wheel substrate during the induction brazing, since it had remarkable influence on the stress and deformation than brazing temperature. The experimental results of the microstructure morphology and deformation proved that the numerical simulation model was correct with 10.4% error.
The association of executive functions and physical fitness with cognitive-motor multitasking in a street crossing scenario
Authors: Mack Melanie , Stojan Robert , Bock Otmar , Voelcker-Rehage Claudia 
Published: August 2022

Abstract
Here, we investigated whether age-related cognitive-motor interference is influenced by individual’s levels of executive functions and physical fitness in a more ecological valid scenario. Participants (N = 61, 65–75 years) crossed a virtual street on a treadmill without getting hit by a car during single- and multitasking (typing numbers). Outcomes were cognitive and motor performance parameters. Further, participants’ executive functions, motor coordinative, and cardiovascular fitness were tested. Linear mixed-effects models showed beneficial main effects of executive functions for the cognitive parameters typing (p = .004) and crossing failures (p = .023), and a beneficial main effect of motor coordinative fitness for the motor parameter stay time (p = .043). We found interaction effects between condition and executive functions for typing (p = .044) with higher benefits during multi- than single-tasking. Commonality analysis revealed an increasing relative contribution of executive functions on cognitive parameters and of motor coordinative fitness on motor parameters from single- to multitasking. Additionally, the proportion of variance commonly explained by executive functions and physical fitness was small for both cognitive and motor parameters. Findings substantiate the benefits of maintaining cognitive functioning and physical fitness up to old age.
Is simultaneous bilateral total hip arthroplasty deleterious in a biomechanical point of view? A comparative gait analysis study
Authors: Caudron Martin , Detrembleur Christine , Cauter Maïté Van 
Published: August 2022

Abstract
Purpose: Uni- or bilateral hip osteoarthritis is a common disease generating pain, stiffness, and functional disabilities. Changes in the normal walking with higher energy expenditures are observed. Facing a cruel lack of biomechanical data, we decided to analyse the impact on the walking of single and simultaneous bilateral total hip arthroplasties (THA).Method: We conducted a prospective monocentric study, comparing two matched groups of 15 patients able to walk with symptomatic isolated uni- (group 1) or bilateral HO (group 2) and treated respectively by unilateral THA (UTHA) or simultaneous bilateral THA (SBTHA). Surgery was performed by a single surgeon with a direct anterior approach and approved by local ethical committee. Walking was assessed by a « 3D Gait analysis motion » pre and at 6 months post operatively.Result: In the UTHA group, recovery, i.e., efficiency of locomotor mechanism (p-value <0.001) and pelvis sagittal balance (p-value 0.03) improved, while external and total work (p-value 0.01) decreased post operatively. In the SBTHA group, speed (p-value 0.03), step length (p-value 0.04), range of motion of knee sagittal stance (p-value 0.009) and hip frontal (p-value 0.03), and internal work are significatively higher (p-value >0.001) post operatively. Conclusions: This original study attests that THA has a positive impact on walking and energetics outcome in UTHA and SBTHA.
Visible-light stimulated synaptic phototransistors based on CdSe quantum dot/In-Ga-Zn-O hybrid channels
Authors: Fu En-bo , Liu Yu , Hou Xiang-Rui , Feng Ye , Yang Chun-lei , Shao Yan 
Published: August 2022

Abstract
Light-stimulated synaptic devices are promising candidates for the development of artificial intelligence systems because of their unique properties, which include broad bandwidths, low power consumption, and superior parallelism. The key to develop such devices is the realization of photoelectric synaptic behavior in them. In this work, visible-light stimulated synaptic transistors based on CdSe quantum dot (CdSe QD)/amorphous In-Ga-Zn-O (a-IGZO) hybrid channels are proposed. This design can not only improve the charge separation efficiency of the photogenerated carriers, but also can induce delayed decay of the photocurrent. The improved charge separation efficiency enhances the photoelectric properties significantly, while the delayed decay of the photocurrent led to the realization of photoelectric synaptic behaviors. This simple and efficient method of fabricating light-stimulated phototransistors may inspire new research progress into the development of artificial intelligence systems.
The Perception of National Youth Service Corps (NYSC) Among Corps Medical Doctors in Nigeria. A Cross- Sectional Study
Authors: Nwachukwu Chibuike Emmanuel , Olufunmilayo Edward Oluwatobi , Chiroma Gideon Bulus , Okoye Chukwuebuka Francis 
Published: August 2022

Abstract
Background: The National Youth Service Corps (NYSC) is a compulsory one-year programme for graduates of tertiary schools including doctors. This study was conducted to explore the perceived benefits and challenges of serving corps medical doctors. The study would influence policy making so as to improve the experiences of corps medical doctors and help NYSC to achieve its objectives.Methods: A descriptive cross-sectional survey was conducted among 399 medical doctors doing their compulsory national youth service in Nigeria. The research instrument was developed by the researchers and pretested before use. The data obtained was analyzed using descriptive statistics and chi-square test using p < 0.05. Results: The majority (83.5%) of respondents believed that the scheme offers one or more benefits to corps medical doctors. These include Exposure to new culture (47.6%), Gaining of medical/surgical skills (36.3%) and finding lover/spouse (4.5%). Similarly, most of respondents (89.2%) reported one or more serious challenges. Some of the perceived challenges reported include; No provision of accommodation (51.6%), poor remuneration (44.7%) and exploitation (41.4%). Majority of the corps doctors expressed dissatisfaction with their job on the scheme reporting that it would have no role to play in their professional development. There was a significant association between job satisfaction and region of deployment (p-value: <0.001), gender (p-value: 0.021) and marital status (p-value: 0.008). The region of deployment and marital status were found to have a statistically significant association with the overall perceived challenges with p-value of 0.012 and < 0.001 respectively. Treatment at Places of Primary Assignment (PPAs) was mostly reported to be fair and it had a statistically significantly association with region of deployment (p-value: 0.012), location of medical school (p-value: 0.023) and gender (p-value: <0.001)Conclusions: The overall perception of NYSC among corps doctors is poor and majority have suggested that the scheme be scrapped or revamped.
Relationship between serum sodium levels and all-cause mortality in congestive heart failure patients: A retrospective cohort study based on the Mimic-III database
Authors: Peng Shixuan , Peng Jianxing , Yang Lianju , Ke Weiqi 
Published: August 2022

Abstract
BACKGROUND: The relationship between serum sodium levels and mortality in congestive heart failure (CHF) patients has not been well studied previously. Serum sodium levels are linked to an increased risk of all-cause death in CHF patients over the short, medium, and long term. Serum sodium levels are strongly linked to an increased risk of death from congestive heart failure and could be a new risk factor for cardiovascular disease. The goal of this study is to look into the relationship between serum sodium levels and all-cause mortality in people with CHF after controlling for other factors.METHODS: The publicly accessible Mimic III database was the source of data for our study. We use the ICU Admission Scoring System to collect demographic data, laboratory findings, comorbidities, vital signs, and scoring information for each patient. Cox proportional risk analysis, smooth curve fitting, and the Kaplan-Meier survival curve were used to assess the relationship between baseline sodium levels and all-cause mortality in CHF patients.RESULTS: The segmentation regression model discovered a turning point value of serum sodium levels (137.5mmol/L) between serum sodium levels and all-cause mortality. According to the results of the fully adjusted Cox proportional hazard model, lower serum sodium levels (<137.5mmol/L) were associated with an increased risk of 30-day, 90-day, 365-day, and 4-year all-cause deaths. The HRs and 95th confidence intervals were 0.96 (0.94, 0.99) , 0.96 (0.94, 0.99), 0.96 (0.94, 0.98) , and 0.96 (0.95, 0.98), respectively; The higher Serum sodium levels(≥137.5mmol/L) were related to associate multiplied risk of 30-day, 90-day, 365-day, and 4-year all-cause deaths; the HRs and 95th confidence intervals were 1.02 (1.00, 1.05), 1.02 (1.00, 1.04), 1.02 (1.00, 1.03) , and 1.02 (1.00, 1.03), respectively.CONCLUSION: Serum sodium levels were u-shaped about all-cause mortality. In individuals with CHF, serum sodium levels are linked to an elevated risk of short-, medium-, and long-term all-cause mortality.
Application of life cycle assessment of system solution scenarios for municipal solid waste management in European Union
Authors: ÇETİNKAYA Afşın Yusuf , BİLGİLİ Levent 
Published: August 2022

Abstract
The aim of this study is to present the results of a life cycle assessment for several scenarios for municipal solid waste management in the European Union. After the entry into force of the European Union Landfill Directive, activities have been taken in succession to establish sustainable MSW management. A life cycle assessment was conducted to determine the environmental impact of municipal solid waste. To determine the environmental effect of various disposal and recovery methods, five different scenarios most commonly used in the European Union were compared: (1) 100% landfill, (2) 100% metals are recycled, remaining waste are sent to incineration, (3) 40% of organic and recyclable waste are composted and recycled, respectively and the remaining wastes are sent to landfill, (4) 100% of organic and recyclable waste are composted and recycled, respectively and the other wastes are sent to landfill, (5) 100% of organic and metal waste are composted and recycled, respectively and the remaining waste are sent to incineration. In Scenario-1, disposal methods contribute significantly to global warming and increase the environmental impact of non-carcinogenic substances. In order to reduce the negative impact on the environment in landfills, the recovery of electricity from methane gas has significantly reduced the potential impact of global warming. The results showed that Scenario-4 and Scenario-5 are more environmentally friendly compared to other scenarios.
Neonatal subgaleal hemorrhage in a multihospital healthcare system: twenty years of trends in incidence, associations, and outcomes
Authors: Christensen Thomas , Henry Erick , Bahr Timothy , Ling Con Yee , Hanton Taylor , Page Jessica , Ilstrup Sarah , Carr Nicholas , Ohls Robin , Christensen Robert 
Published: August 2022

AbstractBACKGROUND:In 2011 we reported 38 neonates with subgaleal hemorrhage (SH), relating that our incidence appeared to be increasing.DESIGN:We retrospectively analyzed every recognized case of SH in our hospitals from the end of our previous report to the present. We redescribed the incidence, compared severity to fetal/neonatal and obstetrical features, tabulated the blood products transfused, and recorded the outcomes at two-years.RESULTS:Across 141 months, 191 neonates were diagnosed with SH; 30 after vacuum or forceps. The overall incidence (one case/1815 births) was higher than in our 2011 report (one case/7124 births). Also, the incidence ofsevereSH (requiring transfusions) was higher (one case/10,033 births) than in our previous report (one case/20,950 births). Four died (all withsevereSH) and 12 had neurodevelopmental impairment at two years.CONCLUSION:Recognized cases of SH are increasing in our healthcare system, without a clear explanation. Adverse outcomes are rare but continue to occur.
Neurogenic timing of the inferior olive subdivisions is related to the olivocerebellar projection topography
Authors: Luo Yuanjun , Chao Yuhan , Zhang Jingyun , Hirata Tatsumi , Sugihara Izumi 
Published: August 2022

Abstract
The olivocerebellar projection is organized into an intricate topographical connection from the inferior olive (IO) subdivisions to the longitudinally-striped compartments of cerebellar Purkinje Cells (PCs) to play an essential role in cerebellar coordination and learning. The central mechanisms for the formation of this topography have been unclear. PCs and IO neurons are generated during overlapping periods of a few days in embryonic development. Here we examined whether their generation timing is specifically involved in the formation of the topographical relationship of the olivocerebellar projection. We mapped neuronal generation timing in the entire IO by using the neurogenic-tagging system of Neurog2-CreER (G2A) mice and specific labeling of IO neurons with FoxP2. IO subdivisions were classified into three groups depending on their neurogenic timing range. Then, we examined the relationships in the neurogenic-timing gradient between PCs and IO neurons based on the reported topographic olivocerebellar projection pattern and PC generation timing. Early, intermediate, and late groups of IO subdivisions projected to late, intermediate, and early groups of the cortical compartments, respectively, except for a few particular areas. The results indicated that the olivocerebellar topographic relationship is essentially arranged according to the reverse neurogenic-timing gradients of the origin and target.