bluuebunny/crossref_metadata_2025_split huggingface dataset:
Проблематика функціонування державного внутрішнього фінансового контролю в Україні
Authors: Loishyn Anatolii , Kustrich Kostiantyn 
Published: September 2022

Мета роботи: ідентифікація проблем функціонування державного внутрішнього фінансового контролю протягом періоду його трансформації і розвитку для врахування результатів дослідження у ході розроблення сучасної концепції державного внутрішнього фінансового контролю.
Дизайн/Метод: проведено декомпозицію та досліджено основні аспекти становлення, розвитку і концептуальної трансформації державного внутрішнього контролю в Україні; сформульовано напрями у проблематиці функціонування державного внутрішнього фінансового контролю на сучасному етапі розвитку та в умовах відсічі збройної агресії російської федерації.
Результати дослідження: використані для розроблення сучасної концепції державного внутрішнього фінансового контролю.
Теоретична цінність дослідження: проведено ретроспективний аналіз становлення, розвитку і концептуальної трансформації державного внутрішнього контролю в Україні та виокремленні проблемних питань у практиці його реалізації, що є базисом для подальшого формулювання сучасних (актуальних) концептуальних засад функціонування державного внутрішнього контролю в Україні з урахуванням безпекової ситуації.
Практична цінність дослідження. Реалізація наданих пропозицій у предметній сфері дослідження дасть змогу підвищити ефективність державного управління в Україні, а також сприятиме економному та результативному використанню обмежених державних ресурсів.
Оригінальність / Цінність дослідження. Дослідження є оригінальним результатом проведеної авторським колективом наукової роботи, що сприяє удосконаленню сучасної теорії і практики у предметній сфері дослідження.
Обмеження дослідження / Майбутні дослідження. Обмеження дослідження полягає у використанні відкритих джерел і даних. Перспективи подальших досліджень вбачаємо у реалізації комплексу заходів запропонованих за результатами цього дослідження.
Тип статті: теоретичний.
Stimulating financing innovative activity
Authors: Zakharin Sergii , Romanovska Natallia , Venger Vitalii , Ramskyi Andrii , Chyzhevska Maryna 
Published: September 2022

Purpose: The aim of the study is to analyze investment activities in Ukraine to determine effective mechanisms and incentives for financing innovative activities.
Design / Method / Research approach. In the national economy of Ukraine, effective models of financing innovative activities, favorable for enterprises that introduce innovations, have not been created. Carrying out innovative activity, which is highly risky and does not always enable to plan profit amount, requires the use of financing flexible forms. Currently, there is no solution to individual issues of strengthening the positive impact of state financial policy on the innovation development in industry, funding sources optimization for innovation. In this regard, it is necessary to clarify the scientific provisions on the substantiation of mechanisms for stimulating the innovative activities financing as an important element of the national economy development state regulation.
Research results. The trends of innovative activity in terms of its financing sources have been analyzed. The problems of organizing the industrial enterprise financing have been highlighted. Prospective ways of solving the problem of financing innovative activities volume increasing and structure improving have been presented. It is necessary to transform the depreciation, budgetary and taxation, credit, technical and technological, foreign trade policy.
Theoretical value of research. It is proposed to modernize the methodological foundations for the targeted comprehensive programs development, implemented in the innovation sphere, which should consider the possibilities of using the appropriate instruments inherent in different areas of public financial policy, primarily budgetary and taxation.
Practical value of research. In order to stimulate innovative activities financing, it is necessary to introduce public-private partnership instruments. Various instruments can be used to solve the problem: direct government funding, government guarantees provision, joint (with a private partner) entrepreneurship (with or without a creation) on the basis of an open transparent tender. Further stimulation of conscientious venture business is advisable.
Originality / Value of research. The research is an original result of scientific work carried out by the author's team.
Research Limitations / Future Research. It is advisable to stimulate a conscientious venture business, which inherently tends to the implementation of innovative activities. The tools for the administration of intellectual property recognized by the world practice should be introduced.
Type of article: theoretical.
Організаційний механізм управління процесом гармонізації сталого господарювання в умовах зростання загроз і ризиків
Authors: Mykytenko Viktoriya , Rogov Petro , Tkach Ivan , Khomik Mykola 
Published: September 2022

Мета роботи: подальший розвиток змістовності понять у сфері управління сталим розвитком, виявлення найвагоміших різноспрямованих факторів впливу на забезпечення сталого господарювання в умовах зростання загроз і ризиків та на результативність управління процесом гармонізації діяльності суб’єктів господарювання відповідно до Європейських вимог.
Дизайн/Метод/Підхід дослідження: теоретичні (аналіз, синтез, узагальнення, порівняння), форсайт-технології та методи опрацьовані в межах теорії струн.
Результати дослідження: запропоновано бінарну структуру, визначено зміст і специфічні функції організаційного механізму управління процесом гармонізації сталого господарювання в умовах зростання загроз і ризиків, що виконано за урахування чотирьох видів струнних взаємодій та їхньої сили й спрямованості. До його складу входять дуальні системоутворюючі регулятори чотири підмеханізми (структурно-функціональний, алармово-безпековий, резонансний та гравітаційний), які забезпечують синхронність функціонування усієї системи управління гармонізацією інтересів усіх суб’єктів за тріадою ключових принципів (генерування властивостей до гармонізації інтересів; управління та коригування властивостями системи сталого господарювання; гармонізації діяльності та збалансування) за рахунок використання специфічного бінарного управлінського інструментарію (функціональних організаційно-економічних засобів та методів, організаційно-економічних засобів та методів забезпечення й підтримки).
Тип статті: дослідницька.
Interface cérebro-máquina: avanços na neurociência e o desenvolvimento de bioeletrodos
Authors: Sousa Wanderson Silva Macedo de , Lopes Danielle Costa , Silva Diego Agripino Chagas , Adad Ana Claudia de Miranda , Ribeiro Jonatas Paulino da Cunha Monteiro , Deus Lyslly Rhanny Soares de , Araújo Gabriela Veiga Macêdo e , Lemos Matheus Sam do Santos , Bispo Tayane de Jesus , Veras Celina Araújo 
Published: September 2022

Objetivo: Mostrar sobre as atualizações desse campo de pesquisa nos últimos anos. Metodologia: trata-se de uma revisão narrativa que são publicações mais amplas. Foram realizadas buscas na base de dados Pubmed e na Biblioteca Virtual em Saúde (BVS). Utilizou-se os Descritores em Ciências da Saúde (DeCS) e Medical Subject Headings (MeSH): “Brain-Computer Interfaces”, “Nervous System”, “Cerebrum” e “Neurosciences.” Incluíram-se artigos publicados entre os anos de 2017 e 2022, em português e inglês e que abordassem avanços da interface cérebro-máquina. Resultados: Foram encontrados 17 artigos que se encaixaram nos critérios de inclusão, todos em inglês. As pesquisas demonstraram avanços significativos que podem ser empregados em processos de reabilitação física motora e sensorial. Conclusão: Verificou-se a aplicação de protocolos e métodos diferentes, o que pode ser um empecilho para a replicação de futuros estudos, no entanto também houve avanços no desenvolvimento de eletrodos biocompatíveis a partir de prolongamentos de axônios, que podem diminuir o processo inflamatório em implantes intracorticais e, observou-se, também, o aprimoramento de codificação e decodificação por métodos não invasivos acoplados em diferentes partes do corpo.
Determination Of Relative Error in Coal Resource Classification Based On Geostatistical Drill Hole Spacing Analysis: A Case Study of Coal Deposits at Batang Hari, Jambi
Authors: Fadhli Muhammad , Setiawan Budhi 
Published: September 2022

Generally, the determination of resource classification is only qualitative based on the geometric factors and geological complexity that control it. However, as the prospect area is found to have a reasonably heterogeneous sediment characteristic, a method is needed that can be used to increase the level of confidence in determining the Optimum Drill Hole Spacing. Therefore, this study uses the application of geostatistics with the global estimation variance (GEV) method based on the relative error value of each parameter, namely the thickness geometry and quality in the form of Ash and VM. This research was carried out in Jangga Aur village, Bathin XXIV District, Batang Hari Regency, Jambi Province, Working Area of PT Berkat Bara Persada Jobsite PT Inti Bara Nusalima.The Drill Hole Spacing Analysis (DHSA) results will obtain optimum spacing on resource classification based on relative error values, namely 0-10% for measured resources, 10-20% for indicated resources, and 20% for Inferred resources carried out the on-seam reference. Based on the results of the study, it was found that the seam reference used was Seam D, then the spacing distance of the drill hole on the coal seam of the research area, which had an average distance of 80 m, with geostatic analysis could be increased up to a distance of 250 m in measured resources, indicated resources of 450 m and Inferred 800 m.
Aliens as Superheroes: Science Fiction, Immigration and Dulce Pinzón’s ‘The Real Story of the Superheroes’
Authors: Leen Catherine 
Published: September 2022

Dulce Pinzón’s photographic series ‘The Real Story of the Superheroes’, celebrates Mexican and Latina/o/x immigrant workers in the United States by radically re-imagining the figure of the super hero. The 2012 book which compiles the images features 20 photographs of immigrant workers living in New York, 18 of whom are from Mexico, while the other two are from Puerto Rico and Ecuador. Pinzón’s work is a striking combination of documentary photography and fantasy, as her subjects go about their everyday jobs dressed as superheroes. She was inspired to take the photographs in the wake of 9/11, when the increased hostility towards migrants in the United States was coupled with an intense celebration of the heroes who attempted to cope with the terrorist attacks and the subsequent resurgence of the superhero genre. Pinzón’s choice of the visual motif of the superhero raises the paradox that these popular cultural icons are frequently engaged in defending the United States from alien invasions, which are often thinly veiled references to fear of immigrants. This chapter contends, however, that Pinzón employs the hybridity inherent in these characters, and which has marked photography in Mexico from its inception, to present alternative heroes using a language that is normally associated with U.S. hegemony and oppression
Disciplinary Form: Introduction to Literary Studies
Authors: Bauer-Gatsos Sheila 
Published: September 2022

This chapter imagines literary studies and the English major as forms and arrangements that provide the space for reflective and careful readings of texts, contexts and lives. Using as its case study a ‘gateway’ introductory course that teaches literature, writing and vocational exploration, this chapter moves through the ways literary studies as a disciplinary form – and specific classroom texts and strategies in particular – can help students shape their college pathways and future decisions. A sense of the changing discipline empowers students to think more broadly about texts as they examine canon-(trans)formation to understand how the discipline has changed in response to new theories, new demands and new ways of seeing the world. Thus, the role of vocational pedagogy in a course focused on the study of English as a discipline can help students understand their callings within and beyond the discipline and to develop the habits of mind for the successful navigation of both.
Multimodal imaging of nano-assembled microspheres loaded with doxorubicin and Cisplatin for liver tumor therapy
Authors: He Yiwei , Zhang Yuqing , Gong Yuanchuan , Zhang Zhewei , Xu Tiancheng , Tian Liqiang , Pan Ting , Yang Hong , Pan Hao , Kou Quanming , Wang Hao , Shao Guoliang 
Published: September 2022

Currently, clinically available drug-loaded embolic microspheres have some shortcomings, such as being invisible with standard medical imaging modalities and only being able to carry positively charged drugs. The visualization of drug-loaded microspheres is very important for real-time monitoring of embolic position to improve the therapeutic effect. Meanwhile, the visualization of microspheres can enable postoperative reexamination, which is helpful for evaluating the embolization area and guiding the subsequent treatment. In addition, microspheres capable of loading different charged drugs can increase the choice of chemotherapeutic drugs and provide more possibilities for treatment. Therefore, it is of great importance to explore drug-loaded microspheres capable of multimodal imaging and loading drugs with different charges for transarterial chemoembolization (TACE) treatment of liver tumors. In our study, we designed a kind of nano-assembled microspheres (NAMs) that can realize computer X-ray tomography (CT)/magnetic resonance imaging (MRI)/Raman multimodal imaging, be loaded with positively and negatively charged drugs and test their imaging ability, drug loading and biological safety. The microspheres have strong attenuation performance for CT, high T2 relaxation for MRI and good sensitivity for surface enhanced Raman spectroscopy (SERS). At the same time, our microspheres can also load the positively charged drug, doxorubicin (DOX), and negatively charged drug Cisplatin. One gram of NAMs can hold 168 mg DOX or 126 mg Cisplatin, which has good drug loading and sustained-release capacity. Cell experiments also showed that the nano-assembled microspheres had good biocompatibility. Therefore, as multimodal developed drug loaded microspheres, nano assembled microspheres have great potential in TACE treatment of liver cancer.
Integrated Kinetic Modelling and Microbial Profiling Provide Insights Into Biological Sulfate-Reducing Reactor Design and Operation
Authors: Hessler Tomas , Harrison Susan T. L. , Huddy Robert J. 
Published: September 2022

Biological sulfate reduction (BSR) is an attractive approach for the bioremediation of sulfate-rich wastewater streams. Many sulfate-reducing microorganisms (SRM), which facilitate this process, have been well-studied in pure culture. However, the role of individual members of microbial communities within BSR bioreactors remains understudied. In this study we investigated the performance of two up-flow anaerobic packed bed reactors (UAPBRs) supplemented primarily with acetate and with lactate, respectively, during a hydraulic retention time (HRT) study set up to remediate sulfate-rich synthetic wastewater over the course of 1,000 + days. Plug-flow hydrodynamics led to a continuum of changing volumetric sulfate reduction rates (VSRRs), available electron donors, degrees of biomass retention and compositions of microbial communities throughout these reactors. Microbial communities throughout the successive zones of the reactors were resolved using 16S rRNA gene amplicon sequencing which allowed the association of features of performance with discrete microorganisms. The acetate UAPBR achieved a maximum VSRR of 23.2 mg.L−1. h−1 at a one-day HRT and a maximum sulfate conversion of the 1 g/L sulfate of 96% at a four-day HRT. The sulfate reduction reactions in this reactor could be described with a reaction order of 2.9, an important observation for optimisation and future scale-up. The lactate UAPBR achieved a 96% sulfate conversion at one-day HRT, corresponding with a VSRR of 40.1 mg.L−1. h−1. Lactate was supplied in this reactor at relatively low concentrations necessitating the subsequent use of propionate and acetate, by-products of lactate fermentation with acetate also a by-product of incomplete lactate oxidation, to achieve competitive performance. The consumption of these electron donors could be associated with specific SRM localised within biofilms of discrete zones. The sulfate reduction rates in the lactate UAPBR could be modelled as first-order reactions, indicating effective rates were conferred by these propionate- and acetate-oxidising SRM. Our results demonstrate how acetate, a low-cost substrate, can be used effectively despite low associated SRM growth rates, and that lactate, a more expensive substrate, can be used sparingly to achieve high VSRR and sulfate conversions. We further identified the preferred environment of additional microorganisms to inform how these microorganisms could be enriched or diminished in BSR reactors.
Femtosecond laser treatment promotes the surface bioactivity and bone ingrowth of Ti6Al4V bone scaffolds
Authors: Wang Su , Zhang Miao , Liu Linlin , Xu Rongwei , Huang Zhili , Shi Zhang’ao , Liu Juncai , Li Zhong , Li Xiaohong , Hao Peng , Hao Yongqiang 
Published: September 2022

In this study, a femtosecond laser with a wavelength of 800 nm was used to modify the surface of a titanium alloy bone scaffold created via selective laser melting (SLM). The outcomes demonstrated that the surface morphology of the bone scaffold after femtosecond laser treatment was micro-nano morphology. The hydrophobic structure of the scaffold was changed into a super-hydrophilic structure, improving the surface roughness, which was highly helpful for osteoblast adhesion and differentiation. The femtosecond laser surface treatment in vitro samples produced a thick layer of hydroxyapatite (HAP) with improved surface bioactivity. The effectiveness of osseointegration and interstitial growth of the specimens treated with the femtosecond laser surface were found to be better when bone scaffolds were implanted into the epiphysis of the tibia of rabbits. As a result, femtosecond laser therapy dramatically enhanced the surface activity of bone scaffolds and their capacity to integrate with the surrounding bone tissues, serving as a trustworthy benchmark for future biological scaffold research.
Efficacy and safety of novel carbapenem–β-lactamase inhibitor combinations: Results from phase II and III trials
Authors: Yu Wei , Shen Ping , Luo Qixia , Xiong Luying , Xiao Yonghong 
Published: September 2022

ObjectivesThe addition of novel β-lactamase inhibitors to carbapenems restores the activity against multidrug-resistant Gram-negative bacteria. The aim of this study was to summarize the evidence on the efficacy and safety of novel carbapenem–β-lactamase inhibitor combinations.MethodsWe conducted a meta-analysis of clinical trials comparing novel carbapenem–β-lactamase inhibitor combinations with comparators to assess the clinical and microbiological responses, mortality, and adverse events (AEs).ResultsA total of 1,984 patients were included. The pooled risk ratios (RRs) of clinical cure, microbiological eradication, all-cause mortality, and 28-day mortality were 1.11 (95% CI: 0.98–1.26), 0.98 (95% CI: 0.82–1.16), 0.90 (95% CI: 0.49–0.94), and 0.68 (95% CI: 0.49–0.94) between the novel carbapenem–β-lactamase inhibitor combinations and control groups. Sensitivity analysis revealed that the phase II trial of imipenem–cilastatin/relebactam (ICR) against complicated urinary tract infections could be the most important factor of heterogeneity for the microbiological response. The therapeutic effect of novel carbapenem–β-lactamase inhibitor combinations was better in meropenem–vaborbactam (MEV), phase III trials, and number of patients less than 200. The RRs of AEs from any cause and serious adverse events (SAEs) for patients receiving novel carbapenem–β-lactamase inhibitor combinations were 0.98 (95% CI: 0.93–1.04) and 1.01 (95% CI: 0.75–1.36), respectively.ConclusionsICR and MEV were superior to comparators for clinical cure and survival rate in the treatment of complicated infections, and both were as tolerable as the comparators.
Meglumine antimoniate was associated with a higher cure rate than liposomal amphotericin B in the treatment of American tegumentary leishmaniasis: A retrospective cohort study from a Leishmania braziliensis-endemic area
Authors: Barroso Daniel Holanda , Gonçalves Renata Trindade , Barbosa Joadyson Silva , da Motta Jorgeth de Oliveira Carneiro , Freire Gustavo Subtil Magalhães , Gomes Ciro Martins , Sampaio Raimunda Nonata Ribeiro 
Published: September 2022

BackgroundPentavalent antimonials (PAs) are the primary therapeutic option for American tegumentary leishmaniasis (ATL). However, the use of these drugs is complicated by adverse events (AEs), resistance and contraindications. Alternative therapies relative effectiveness is not well established.ObjectiveThis study compared the effectiveness of liposomal amphotericin B (LAB) with intravenous meglumine antimoniate (NMG) in the treatment of ATL. We also analysed and compared associated AEs and treatment interruption rates.MethodsThis was a retrospective cohort study from Brazil. The potential risk factors for the primary outcome were age, sex, total cutaneous lesion area, presence of mucosal lesions, AEs and treatment interruption. The primary outcome was lesion healing within 6 months of treatment. AEs and treatment interruption were also analysed. Multiple analytic strategies were employed to evaluate the reliability of the results.ResultsBefore propensity score (PS) matching, patients in the LAB group were older and had a higher frequency of mucosal lesions. The NMG group had a higher cure rate than the LAB group (cure rate 88% versus 55% respectively) in the adjusted analysis (relative risk (RR)=1.55 95% CI: 1.19 - 2.02) and after PS matching (RR=1.63 95% CI: 1.20 - 2.21). NMG group had a higher AE rate (event rate 52% versus 44%) in the adjusted analysis (RR= 1.61, 95% CI: 1.06 - 2.43, p=0.02), but this result was not observed after PS matching (RR= 0.87, 95% CI: 0.49 -1.52, p= 0.61).ConclusionsWe observed that the NMG group had a higher cure rate than the LAB group, with an equivocally higher EV rate in the adjusted analysis.