bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the protected spectrum of the minimal Argyres-Douglas theory
Authors: Bhargava Chinmaya , Buican Matthew , Jiang Hongliang 
Published: August 2022

Abstract
Despite the power of supersymmetry, finding exact closed-form expressions for the protected operator spectra of interacting superconformal field theories (SCFTs) is difficult. In this paper, we take a step towards a solution for the “simplest” interacting 4D $$ \mathcal{N} $$
N
= 2 SCFT: the minimal Argyres-Douglas (MAD) theory. We present two results that go beyond the well-understood Coulomb branch and Schur sectors. First, we find the exact closed-form spectrum of multiplets containing operators that are chiral with respect to any $$ \mathcal{N} $$
N
= 1 ⊂ $$ \mathcal{N} $$
N
= 2 superconformal subalgebra. We argue that this “full” chiral sector (FCS) is as simple as allowed by unitarity for a theory with a Coulomb branch and that, up to a rescaling of U(1)r quantum numbers and the vanishing of a finite number of states, the MAD FCS is isospectral to the FCS of the free $$ \mathcal{N} $$
N
= 2 Abelian gauge theory. In the language of superconformal representation theory, this leaves only the spectrum of the poorly understood $$ {\overline{\mathcal{C}}}_{R,{r}_{\left(j,\overline{j}\right)}} $$

C
¯

R
,

r

j

j
¯

multiplets to be determined. Our second result sheds light on these observables: we find an exact closed-form answer for the number of $$ {\overline{\mathcal{C}}}_{0,{r}_{\left(j,0\right)}} $$

C
¯

0
,

r

j
0

multiplets, for any r and j, in the MAD theory. We argue that this sub-sector is also as simple as allowed by unitarity for a theory with a Coulomb branch and that there is a natural map to the corresponding sector of the free $$ \mathcal{N} $$
N
= 2 Abelian gauge theory. These results motivate a conjecture on the full local operator algebra of the MAD theory.
AI-assisted biparametric MRI surveillance of prostate cancer: feasibility study
Authors: Roest C. , Kwee T.C. , Saha A. , Fütterer J.J. , Yakar D. , Huisman H. 
Published: August 2022

Abstract
Objectives
To evaluate the feasibility of automatic longitudinal analysis of consecutive biparametric MRI (bpMRI) scans to detect clinically significant (cs) prostate cancer (PCa).

Methods
This retrospective study included a multi-center dataset of 1513 patients who underwent bpMRI (T2 + DWI) between 2014 and 2020, of whom 73 patients underwent at least two consecutive bpMRI scans and repeat biopsies. A deep learning PCa detection model was developed to produce a heatmap of all PIRADS ≥ 2 lesions across prior and current studies. The heatmaps for each patient’s prior and current examination were used to extract differential volumetric and likelihood features reflecting explainable changes between examinations. A machine learning classifier was trained to predict from these features csPCa (ISUP > 1) at the current examination according to biopsy. A classifier trained on the current study only was developed for comparison. An extended classifier was developed to incorporate clinical parameters (PSA, PSA density, and age). The cross-validated diagnostic accuracies were compared using ROC analysis. The diagnostic performance of the best model was compared to the radiologist scores.

Results
The model including prior and current study (AUC 0.81, CI: 0.69, 0.91) resulted in a higher (p = 0.04) diagnostic accuracy than the current only model (AUC 0.73, CI: 0.61, 0.84). Adding clinical variables further improved diagnostic performance (AUC 0.86, CI: 0.77, 0.93). The diagnostic performance of the surveillance AI model was significantly better (p = 0.02) than of radiologists (AUC 0.69, CI: 0.54, 0.81).

Conclusions
Our proposed AI-assisted surveillance of prostate MRI can pick up explainable, diagnostically relevant changes with promising diagnostic accuracy.

Key Points
• Sequential prostate MRI scans can be automatically evaluated using a hybrid deep learning and machine learning approach.
• The diagnostic accuracy of our csPCa detection AI model improved by including clinical parameters.
Exercise and colorectal cancer survival: an updated systematic review and meta-analysis
Authors: Choy Kay T. , Lam Kenneth , Kong Joseph C. 
Published: August 2022

Abstract
Purpose
The benefit of exercise to colorectal cancer patients has been advocated. However, comparative data to quantify the survival benefit is lacking. The aim of this review was to assess the effect of exercise on colorectal cancer survival.

Methods
An up-to-date systematic review was performed on the available literature between 2000 and 2021 on PubMed, EMBASE, Medline, and Cochrane Library databases. All studies reporting on the impact of exercise and colorectal cancer outcomes in patients treated for non-metastatic colorectal cancer were analysed. The main outcome measures were the overall survival (OS), cancer specific survival (CSS) and disease free survival (DFS).

Results
A total of 13 prospective observational studies were included, accounting for 19,135 patients. Compared to negligible physical activity, overall survival (OS) was significantly increased for both moderate and highest activity group (HR 0.82, 95% CI: 0.74–0.90, p < 0.001 and HR 0.64, 0.56–0.72, p < 0.001 respectively). This was also reflected in cancer specific survival (CSS) analysis, but not disease-free survival (DFS) analysis.

Conclusion
Exercise was associated with an increased in overall survival after a colorectal cancer resection. This would support the promotion of exercise interventions amongst colorectal cancer patients.
Homology of neocortical areas in rats and primates based on cortical type analysis: an update of the Hypothesis on the Dual Origin of the Neocortex
Authors: García-Cabezas Miguel Ángel , Hacker Julia Liao , Zikopoulos Basilis 
Published: August 2022

AbstractSixty years ago, Friedrich Sanides traced the origin of the tangential expansion of the primate neocortex to two ancestral anlagen in the allocortex of reptiles and mammals, and proposed the Hypothesis on the Dual Origin of the Neocortex. According to Sanides, paraolfactory and parahippocampal gradients of laminar elaboration expanded in evolution by addition of successive concentric rings of gradually different cortical types inside the allocortical ring. Rodents had fewer rings and primates had more rings in the inner part of the cortex. In the present article, we perform cortical type analysis of the neocortex of adult rats, Rhesus macaques, and humans to propose hypotheses on homology of cortical areas applying the principles of the Hypothesis on the Dual Origin of the Neocortex. We show that areas in the outer rings of the neocortex have comparable laminar elaboration in rats and primates, while most 6-layer eulaminate areas in the innermost rings of primate neocortex lack homologous counterparts in rats. We also represent the topological distribution of cortical types in simplified flat maps of the cerebral cortex of monotremes, rats, and primates. Finally, we propose an elaboration of the Hypothesis on the Dual Origin of the Neocortex in the context of modern studies of pallial patterning that integrates the specification of pallial sectors in development of vertebrate embryos. The updated version of the hypothesis of Sanides provides explanation for the emergence of cortical hierarchies in mammals and will guide future research in the phylogenetic origin of neocortical areas.
Role of surgery to the primary tumor in metastatic anaplastic thyroid carcinoma: pooled analysis and SEER-based study
Authors: Oliinyk Dmytro , Augustin Teresa , Rauch Josefine , Koehler Viktoria Florentine , Belka Claus , Spitzweg Christine , Käsmann Lukas 
Published: August 2022

Abstract
Purpose
Anaplastic thyroid carcinoma (ATC) is an orphan disease with a fatal outcome. Surgery to the primary tumor in metastatic ATC is controversial. Determination of specific surgical techniques may help facilitate local control and, hence, beneficial overall and disease-specific survival.

Methods
Using individualized patient data derived from our systematic review of literature and our single center study (n = 123), conducting a Surveillance, Epidemiology, and End Results register (SEER)-based study (n = 617) we evaluated surgery, its combination with systemic and local therapies in metastatic ATC.

Results
Pooled cohort study showed surgery (p < 0.001), RT ≥ 30 Gy (p < 0.001), ChT (p < 0.001) and multimodal treatment (p = 0.014) to result in improved OS univariately. In the multivariate analysis, surgery (1.997 [1.162–3.433], p = 0.012) and RT ≥ 30 Gy (1.877 [1.232–2.843], p = 0.012) were independent predictors for OS. In SEER-based study of patients undergoing any tumor-directed treatment (n = 445) total thyroidectomy (p = 0.031), administration of ChT (p = 0.007), RT (p < 0.001), combination of surgery and RT ± ChT (p < 0.001) and multimodal treatment (p < 0.001) correlated with an improved DSS univariately. On the multivariate analysis, debulking surgery was an independent predictor for a worse outcome (HR 0.535, 95%CI 0.332–0.862, p = 0.010), whereas RT administration correlated with a longer DSS (HR 2.316, 95%CI 1.362–3.939, p = 0.002). Among operated patients from SEER register total thyroidectomy (p = 0.031), ChT (p = 0.007), RT (p < 0.001), combination of surgery and RT ± ChT (p < 0.001) and multimodal treatment (p < 0.001) correlated with an improved DSS in the univariate analysis, whereas debulking surgery was inversely correlated with the DSS (p < 0.001). On the multivariate analysis, debulking surgery was an independent predictor for a worse DSS (HR 0.535, 95%CI 0.332–0.862, p = 0.010), whilst RT administration correlated with a longer DSS (HR 2.316, 95%CI 1.362–3.939, p = 0.002).

Conclusions
Surgery to the primary tumor with the aim of R0/R1 resection, but not debulking, is associated with a significant OS and DSS benefit even in systemically metastasized disease.
Oculo-vestibular signs in experimentally induced migraine attacks: an exploratory analysis
Authors: Corrado Michele , Demartini Chiara , Greco Rosaria , Zanaboni Annamaria , Bighiani Federico , Vaghi Gloria , Grillo Valentina , Sances Grazia , Allena Marta , Tassorelli Cristina , De Icco Roberto 
Published: August 2022

AbstractVestibular symptoms accompanying headache are quite common in migraine patients. Based on the association of vertigo with migraine, vestibular migraine was included in the appendix of the 3rd edition of the International Classification of Headache Disorders as a possible migraine subtype worthy of further investigation. In this post hoc, exploratory analysis, we investigated the occurrence of oculo-vestibular signs (OVSs) during experimentally induced migraine attacks in 24 episodic migraine patients and 19 healthy controls exposed to sublingual nitroglycerin (NTG - 0.9 mg). A comprehensive clinical examination was performed at baseline, at the onset of the migraine-like attack, and immediately before hospital discharge (180 minutes after NTG administration). Three of the 13 migraine patients who developed a spontaneous-like migraine attack during the hospital observation period (23.1%) also developed OVSs during the induction test. Noteworthy, none of the patients with a negative induction test developed OVSs and no OVSs were reported in healthy subjects at any time point. The exploratory nature of our study does not allow to draw definite conclusions on the possible implications of a vestibular dysfunction in migraine pathophysiology. Our results however suggest that NTG administration may lend itself to investigate vestibular dysfunction in migraine, at least in a subset of patients. The present findings represent a starting point for designing future ad hoc and well-powered studies.
An executable metamodel refactoring catalog
Authors: Bettini Lorenzo , Di Ruscio Davide , Iovino Ludovico , Pierantonio Alfonso 
Published: August 2022

AbstractLike any software artifacts, metamodels are evolving entities that constantly change over time for different reasons. Changing metamodels by keeping them consistent with other existing artifacts is an error-prone and tedious activity without the availability of automated support. In this paper, we foster the adoption of metamodel refactorings collected in a curated catalog. The Edelta framework is proposed as an operative environment to provide modelers with constructs for specifying basic refactorings and evolution operators, to define a complete metamodel refactoring catalog. The proposed environment has been used to implement the metamodel refactorings available in the literature and make them executable. A detailed discussion on how modelers can use and contribute to the definition of the catalog is also given.
Community support for caring relatives of people with dementia: qualitative analysis using the Theoretical Domains Framework
Authors: Wittek Maren , Voß Henrike , Kiefer Anna , Wiloth Stefanie , Schmitt Eric 
Published: August 2022

Abstract
Aim
Although caring relatives of people with dementia are a mainstay of many care systems, the availability of support services for them within the municipal community shows deficiencies. Adopting the Theoretical Domains Framework (TDF) this study aims to investigate 1) which of the TDF domains adapted to gerontology show up in public dialogue, and 2) the results that public dialogues produce in terms of support services for caring relatives.

Subject and methods
The data consists of town hall meetings and focus groups from 14 municipal communities in Germany. Participants were caring relatives and stakeholders of the communities. A qualitative content analysis was conducted, focusing on the assessment of three TDF domains, namely knowledge, goals, and sociopolitical context as well as outcomes of care optimisation.

Results
With regard to domain knowledge, it was evident that in every community there were actors aware of the situation and relevance of carers and their relatives. Only some actors mentioned goals for optimising the care of the target group. The sociopolitical context is often addressed through statements about incomplete requirements.

Conclusion
Overall, a relation between the discussion about the domains in public dialogues and changes in supporting carers of people with dementia can be assumed. The results indicate that an increased discussion about the domains within town hall meetings influences the actors and their statements with regard to the improvement of support services for caring relatives of people with dementia. Since the domains were not developed exclusively for the outlined context, this approach can also be applied to other areas of care.
On-Field Deployment and Validation for Wearable Devices
Authors: Kuo Calvin , Patton Declan , Rooks Tyler , Tierney Gregory , McIntosh Andrew , Lynall Robert , Esquivel Amanda , Daniel Ray , Kaminski Thomas , Mihalik Jason , Dau Nate , Urban Jillian 
Published: August 2022

AbstractWearable sensors are an important tool in the study of head acceleration events and head impact injuries in sporting and military activities. Recent advances in sensor technology have improved our understanding of head kinematics during on-field activities; however, proper utilization and interpretation of data from wearable devices requires careful implementation of best practices. The objective of this paper is to summarize minimum requirements and best practices for on-field deployment of wearable devices for the measurement of head acceleration events in vivo to ensure data evaluated are representative of real events and limitations are accurately defined. Best practices covered in this document include the definition of a verified head acceleration event, data windowing, video verification, advanced post-processing techniques, and on-field logistics, as determined through review of the literature and expert opinion. Careful use of best practices, with accurate acknowledgement of limitations, will allow research teams to ensure data evaluated is representative of real events, will improve the robustness of head acceleration event exposure studies, and generally improve the quality and validity of research into head impact injuries.
A Combined Numerical and Experimental Investigation of Cycle-to-Cycle Variations in an Optically Accessible Spark-Ignition Engine
Authors: Chu Hongchao , Welch Cooper , Elmestikawy Hani , Cao Shangyi , Davidovic Marco , Böhm Benjamin , Dreizler Andreas , Pitsch Heinz 
Published: August 2022

AbstractA combined numerical and experimental investigation is carried out to analyze the cycle-to-cycle variations (CCV) in an optically accessible spark-ignition engine with port fuel injection. A stable and an unstable operating condition is considered. Well-established turbulence, combustion, and ignition models are employed in the large-eddy simulations (LES). High-speed measurements of the velocity field via particle image velocimetry and flame imaging in the tumble plane are conducted in the experiments. A detailed comparison between LES and experiments is carried out, including the in-cylinder pressure, the flow fields, the spatial flame distribution, and the fields conditioned on fast and slow cycles. Good agreement is achieved for the variables considering all cycles; yet, some discrepancies are observed for the conditionally averaged quantities. A systematic quantitative correlation analysis between the selected influencing variables and the CCV is presented, in which the influencing variables are extracted from different length scales (r = 3 mm, 12 mm, and 43 mm) and the CCV are distinguished between the early flame kernel development and later flame propagation. Even though the most relevant influencing parameters are different for the two operating conditions, the location of the coherent vortex structure is found to be important for the CCV of both cases.
Altruist Talk May (also) Be Cheap: Revealed Versus Stated Altruism as a Predictor in Stated Preference Studies
Authors: Iversen Endre Kildal , Grimsrud Kristine , Mitani Yohei , Lindhjem Henrik 
Published: August 2022

AbstractAltruistic preferences have been found to be important for explaining the substantial non-use values identified in numerous stated preference surveys. However, studies analysing the effect of altruism on willingness to pay (WTP) have underestimated the challenges of measuring altruism by stated measures. We exploit a naturally occurring decision domain to investigate the role of altruism in stated preference studies. We employ a novel dataset, collected from an Internet survey panel, that contains respondents’ past donations of earned survey coins to charities and use these data to analyse the effect of donation behaviour on the same respondents’ WTP. We analyse donation behaviour across two contingent valuation surveys on environmental topics. Donators are proven givers in an anonymous and unrelated setting, much like decision-making in a dictator game. We find that respondents’ past donations are associated with higher WTP, even after controlling forstatedmeasures of altruism, ecological, and environmental attitudes. The results suggest that measures of stated altruism fail to capture important aspects of altruism, implying that previous studies of altruism based on such measures may be questioned. The results also support research demonstrating that altruistic behaviour in one decision domain is a good predictor of altruistic behaviour in other domains.
Using the Constitutionality Framework to Understand Alliances, Collective Action, and Divisions Between Indigenous and Peasant Communities in the Chaco Salteño
Authors: Tschopp Maurice , Inguaggiato Carla , Saravia Rodrigo Chavez , Ceddia Michele Graziano 
Published: August 2022

AbstractThis article analyzes bottom-up institution-building processes in a region considered deforestation and environmental degradation hotspot. Utilizing the constitutionality approach developed by Haller, Acciaioli, and Rist (2016), we examine two recent cases of bottom-up institution-building in the department of Rivadavia, Chaco Salteño, Argentina. We highlight the similarities and differences between both constitutionality processes and identify various weaknesses in the two cases. We argue that constitutionality, understood as a process, has occurred to different (incomplete) degrees in each case. Finally, we show that external catalyzing agents play a decisive role in enabling or hampering the constitutionality process. Our study contributes to the literature on common-pool resource governance by highlighting how collective action can lead to participatory-development processes.
Misunderstood Stoicism: The negative Association Between Stoic Ideology and well-Being
Authors: Karl Johannes Alfons , Verhaeghen Paul , Aikman Shelley N. , Solem Stian , Lassen Espen R. , Fischer Ronald 
Published: August 2022

AbstractAncient philosophy proposed a wide range of possible approaches to life which may enhance well-being. Stoic philosophy has influenced various therapeutic traditions. Individuals today may adopt an approach to life representing a naive Stoic Ideology, which nevertheless reflects a misinterpretation of stoic philosophy. How do these interpretations affect well-being and meaning in life? We examine the differential effects of Stoic Ideology on eudaimonic versus hedonic well-being across three cultural contexts. In this pre-registered study, across samples in New Zealand (N = 636), Norway (N = 290), and the US (N = 381) we found that a) Stoic Ideology can be measured across all three contexts and b) Converging evidence that Stoic Ideology was negatively related to both hedonic well-being and eudaimonic well-being. Focusing on specific relationships, we found especially pronounced effects for Taciturnity (the desire to not express emotions) and Serenity (the desire to feel less emotions). Despite being a misinterpretation of stoic philosophy, these findings highlight the important role of individuals’ orientations to emotional processing for well-being.
Flame retarded polymer systems based on the sol-gel approach: recent advances and future perspectives
Authors: Bifulco Aurelio , Imparato Claudio , Aronne Antonio , Malucelli Giulio 
Published: August 2022

AbstractThe ease of flammability of polymers represents a key issue that limits their applications in different advanced sectors. In this context, a reliable and effective solution regards the use of flame retardants, i.e., additives that are able to slow down (or even stop) the flame propagation and to enhance the resistance to an irradiative heat flux. Among the different flame retardants designed, synthesized, and applied up-to-now, the utilization of inorganic particles, inorganic and hybrid organic-inorganic coatings has gathered a great interest from either the academic and industrial community, as these structures can provide remarkable flame retardant features to different polymer systems, in which they are embedded or applied onto. In particular, the in situ generation (through sol-gel processes, i.e. hydrolysis and condensation reactions from tailored alkoxide precursors) of ceramic phases, either in the form of particles or as surface coatings, has clearly demonstrated its effectiveness in creating a physical barrier that limits the degradation of the polymer when subjected to the application of a flame or an irradiative heat flux. It also lowers the heat and mass transfer from the degrading polymer to the surroundings and vice versa, hence providing an overall enhancement of heat and fire resistance. This review work seeks to provide an up-to-date overview of the most recent advances in the use of sol-gel methods for conferring flame retardant features to bulk polymers, cellulosic textiles (cotton), and polymer foams. In addition, the current limitations and the potential progresses of these approaches are discussed.