bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Features, Diagnosis, Management and Prognosis of Primary Intraocular Lymphoma
Authors: Zhao Xin-yu , Cheng Tian-tian , Meng Li-hui , Zhang Wen-fei , Chen You-xin 
Published: February 2022

PurposeTo evaluate the clinical features, diagnostic techniques, various treatment strategies and prognosis of primary intraocular lymphoma (PIOL).MethodsThe databases PubMed, EMBASE, and Ovid were searched from inception to March 2021 to identify relevant studies. Statistical analyses were performed with R version 3.3.1.Results87 studies involving 1484 patients (aged from 14 to 90 years old) were finally included. The pooling results indicated PIOL patients were female, elderly, binocular and B cell type dominated. About 19% have central nervous system (CNS) involvement at the first visit. During follow-up, the incidence of CNS involvement, death rate, 2-year and 5-year survival rate, 1-year and 2-year progression-free survival, and recurrence rate were 58%, 33%, 82%, 70%, 88%, 70%, 44%, respectively. The most common recurrent site was CNS. The delayed diagnosis rate was 85%, the misdiagnosed rate was 64%. The diagnostic technique with the highest positive rate was IL10:IL6&gt;1 of aqueous (98%). The most common symptoms, signs, FFA and OCT features were blurring of vision (72%), vitreous inflammatory opacity (92%), FA/FAF reversal (91%) and hyper-reflective foci in posterior vitreous (53%), respectively. The prognosis of PIOL patients without CNS involvement was obviously better than those with CNS involvement. Overall, intravitreal injection of chemotherapy drug plus systemic chemotherapy (IV+CT) could achieve satisfactory prognosis, the combination of local radiotherapy (RT) could further decrease the recurrent and death rate.ConclusionPIOL patients with CNS involvement had significantly worse prognosis. The aqueous humor examination should be regarded as first-line and routine diagnostic technique. IV+CT could achieve satisfactory prognosis, the combination of RT was also beneficial.
Real-World Practice of Hypofractionated Radiotherapy in Patients With Invasive Breast Cancer
Authors: Chen Fang , Hui Timothy S.K. , Ma Lingyu , Nong Yaqing , Han Ying , Jing Haiman , Lee Eric K.W. , Xu Zhiyuan , Fu Pingfu , Chang Amy Tien Yee , Hsue Victor , Kong Feng-Ming Spring 
Published: February 2022

PurposeApplication of hypofractionated radiotherapy (HFRT) is growing in patients with breast cancer (BC). This study aimed to explore a real-world practice of HFRT in early and locally advanced BC.MethodsPatients with invasive BC between 2015 and 2019 were retrospectively reviewed. Radiotherapy (RT) was delivered by HFRT and conventionally fractionated radiotherapy (CFRT). Locoregional recurrence-free survival (LRRFS) and disease-free survival (DFS) were calculated by Kaplan–Meier curve and compared by Log-rank test. The effect of treatment modality on DFS was estimated by univariate and multivariable analyses.ResultsA total of 1,010 patients were included in this study, and 903 (89.4%) were treated with HFRT. At a median follow-up of 49.5 months, there was no significant difference in a 4-year cumulative incidence of LRRFS in HFRT group (1.5%) and in CFRT group (3.8%) (p = 0.23), neither in different nodal stages nor in N2–3 patients with different molecular subtypes. The 4-year DFS was 93.5% in HFRT group compared with 89.9% in CFRT group with no significant difference either (p = 0.17). Univariate and multivariable analyses also showed no significant difference in DFS between HFRT and CFRT group. However, DFS of HFRT group tended to be lower in N2–3 patients with triple negative BC compared with that of CFRT group (76.2% versus 100%).ConclusionHFRT can achieve similar cumulative incidence of LRRFS and DFS in patients with BC after lumpectomy or mastectomy, and also in different nodal stage, and in locally advanced stage with different molecular subtypes.
Alzheimer’s Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In APP Mouse Model
Authors: Aldabbagh Yousif , Islam Anam , Zhang Weicong , Whiting Paul , Ali Afia B. 
Published: February 2022

Cognitive decline is a major symptom in Alzheimer’s disease (AD), which is strongly associated with synaptic excitatory-inhibitory imbalance. Here, we investigated whether astrocyte-specific GABA transporter 3/4 (GAT3/4) is altered in APP knock-in mouse model of AD and whether this is correlated with changes in principal cell excitability. Using the APPNL-F/NL-F knock-in mouse model of AD, aged-matched to wild-type mice, we performed in vitro electrophysiological whole-cell recordings combined with immunohistochemistry in the CA1 and dentate gyrus (DG) regions of the hippocampus. We observed a higher expression of GAD67, an enzyme that catalyses GABA production, and GAT3/4 in reactive astrocytes labelled with GFAP, which correlated with an enhanced tonic inhibition in the CA1 and DG of 12–16 month-old APPNL-F/NL-F mice compared to the age-matched wild-type animals. Comparative neuroanatomy experiments performed using post-mortem brain tissue from human AD patients, age-matched to healthy controls, mirrored the results obtained using mice tissue. Blocking GAT3/4 associated tonic inhibition recorded in CA1 and DG principal cells resulted in an increased membrane input resistance, enhanced firing frequency and synaptic excitation in both wild-type and APPNL-F/NL-F mice. These effects exacerbated synaptic hyperactivity reported previously in the APPNL-F/NL-F mice model. Our data suggest that an alteration in astrocyte GABA homeostasis is correlated with increased tonic inhibition in the hippocampus, which probably plays an important compensatory role in restoring AD-associated synaptic hyperactivity. Therefore, reducing tonic inhibition through GAT3/4 may not be a good therapeutic strategy for AD
An Overview of Systematic Reviews of Moxibustion for Knee Osteoarthritis
Authors: Yin Shao , Zhu Fengya , Li Zhao , Che Deya , Li Liuying , Feng Jie , Zhang Lu , Huo Zhenyi 
Published: February 2022

BackgroundCurrently, many systematic reviews (SRs) of moxibustion as a treatment of KOA have been published. However, the evidence of different SRs of moxibustion to treat KOA has not been comprehensively evaluated.AimThis overview aimed to evaluate the existing results and provide scientific evidence of the effectiveness and safety of moxibustion in the treatment of KOA.MethodsWe conducted a comprehensive search of Embase, PubMed, Web of Science, Cochrane Library, SinoMed, CNKI, Wanfang, VIP, and other databases until October 31, 2021. A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR-2) was used to assess the methodological quality of SRs. Preferred Reporting Item for Systematic Reviews and Meta-Analyses was used to evaluate the reporting quality, and the risk of bias in SRs was evaluated by ROBIS Tool. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool to determine the strength of evidence and conducted a meta-analysis of the total effectiveness rate.ResultsFinally, 10 qualified SRs were included, including 57 randomized controlled trials and 5,149 participants. All SRs evaluated by AMASTAR-2 had more than one critical deficiency, so all SRs were rated as critically low. In the PRISMA checklist, the manuscript structures of the included SRs were relatively complete. Including four SRs with a low risk of bias and six with a high risk of bias using the ROBIS tool. In GRADE, two items (6.25%) were rated as high quality, three (9.37%) as medium quality, 17 (53.12%) as low quality and 10 (31.25%) as very low quality. A re-meta-analysis showed that moxibustion and moxibustion combined treatment improved the total effectiveness rate in knee osteoarthritis (risk ratio = 1.17, 95% confidence interval 1.13–1.21, P &lt; 0.001 and risk ratio = 1.13, 95% CI: 1.04–1.23, P &lt; 0.001), with low heterogeneity (I2 = 36.3%, P = 0.020, and I2 = 0.0%, P = 0.956). A total of eight SRs reported adverse events, and no serious adverse events occurred in the moxibustion group and control group.ConclusionMoxibustion seems to be effective in treating KOA. Four SRs reported 10 common discomfort symptoms caused by moxibustion, and these adverse events can spontaneously subside, even can be avoided, therefore, moxibustion for KOA appears to be safe. However, the reliability of the results is reduced by the high risk of bias of the original studies and the low methodological quality of SRs. Therefore, future studies should pay more attention to the quality of the original study and the evidence quality of the SRs to provide more powerful and scientific evidence of the effectiveness and safety of moxibustion treatment of KOA.
The Prevalence of Psychological Distress and Its Relationship to Sleep Quality in Saudi Arabia's General Population During the COVID-19 Pandemic
Authors: AlRasheed Maha M. , Al-Aqeel Sinaa , Alkadir Afnan M. , Bin Shuqiran Khulood , Khurshid Fowad , AlRasheed Noura M. , Al-kufeidy Roua M. , Alhaj Omar A. , Jahrami Haitham , BaHammam Ahmed S. 
Published: February 2022

BackgroundWe aimed to examine the effect of the COVID-19 pandemic and associated mitigation measures on sleep quality and psychological distress in Saudi Arabia.MethodsSubjective sleep quality over the preceding 30 days was measured using the Pittsburgh Sleep Quality Index (PSQI). In addition, Kessler Psychological Distress Scale (K10) was used to assess the psychological distress.ResultsThe study included 836 participants. The median age was 28 years, 624 (74.64%) were females, and 158 (18.90%) were healthcare workers. Factors associated with poor sleep were recent changes in the sleep habits p = 0.004), anxiety or fear because of coronavirus news on social media p = 0.02), fear because there was no approved drug to treat COVID-19 p = 0.03), and unaware of the presence of chronic diseases p = 0.03). Female gender p = 0.02), fear or anxiety because of coronavirus news on social media p = 0.04), recent change in sleep habits (OR: 1.97 (1.15–3.39); p = 0.01), fear because there is no approved drug to treat COVID-19 p = 0.001), monthly income &lt;1000 SR p = 0.01), and isolation p = 0.01) were associated with distress. PSQI and K10 scores were significantly correlated p &lt; 0.001).ConclusionPoor sleep and psychological distress are common during the COVID-19 outbreak in Saudi Arabia. Identifying factors associated with poor sleep and psychological distress would help develop specific intervention programs that enhance mental health and sleep quality during pandemics.
Associations Among Maternal Metabolic Conditions, Cord Serum Leptin Levels, and Autistic Symptoms in Children
Authors: Iwabuchi Toshiki , Takahashi Nagahide , Nishimura Tomoko , Rahman Md Shafiur , Harada Taeko , Okumura Akemi , Kuwabara Hitoshi , Takagai Shu , Nomura Yoko , Matsuzaki Hideo , Ozaki Norio , Tsuchiya Kenji J. 
Published: February 2022

IntroductionAccumulating evidence has shown that maternal metabolic conditions, such as pre-pregnancy overweight, diabetes mellitus, and hypertensive disorders of pregnancy (HDP) are potential risk factors of autism spectrum disorder (ASD). However, it remains unclear how these maternal conditions lead to neurodevelopmental outcomes in the offspring, including autistic symptoms. Leptin, an adipokine that has pro-inflammatory effects and affects fetal neurodevelopment, is a candidate mediator of the association between maternal metabolic factors and an increased risk of ASD. However, whether prenatal exposure to leptin mediates the association between maternal metabolic conditions and autistic symptoms in children has not been investigated yet.MethodsThis study investigated the associations between mothers' metabolic conditions (pre-pregnancy overweight, diabetes mellitus during or before pregnancy, and HDP), leptin concentrations in umbilical cord serum, and autistic symptoms among 762 children from an ongoing cohort study, using generalized structural equation modeling. We used the Social Responsive Scale, Second Edition (SRS-2) at 8–9 years old to calculate total T-scores. Additionally, we used the T-scores for two subdomains: Social Communication and Interaction (SCI) and Restricted Interests and Repetitive Behavior (RRB).ResultsUmbilical cord leptin levels were associated with pre-pregnancy overweight [coefficient = 1.297, 95% confidence interval (CI) 1.081–1.556, p = 0.005] and diabetes mellitus (coefficient = 1.574, 95% CI 1.206–2.055, p = 0.001). Furthermore, leptin levels were significantly associated with SRS-2 total T-scores (coefficient = 1.002, 95% CI 1.000–1.004, p = 0.023), SCI scores (coefficient = 1.002, 95% CI 1.000–1.004, p = 0.020), and RRB scores (coefficient = 1.001, 95% CI 1.000–1.003, p = 0.044) in children. Associations between maternal metabolic factors and autistic symptoms were not significant.DiscussionThe present study uncovered an association between cord leptin levels and autistic symptoms in children, while maternal metabolic conditions did not have an evident direct influence on the outcome. These results imply that prenatal pro-inflammatory environments affected by maternal metabolic conditions may contribute to the development of autistic symptoms in children. The findings warrant further investigation into the role of leptin in the development of autistic symptoms.
Créer, discipliner et diriger le désordre. Le contrôle du processus de travail paysan : une proposition sur son articulation (Xe-XIe siècle)
Authors: Barceló Miquel 
Published: February 2022

To create, order and manage disorder. The control of the agricultural work process: a proposal concerning its structuring.
The aim of this paper is to show how the control over peasant work - usually referred to as «rent» in institutional terms - could eventually permeate the very organisation of production, and thus, increasingly orient it towards a selection of plants most amenable to being stocked, transformed and commercialized. All this implied an increasingly active and rigorous discipline of peasant work. As a result, the erosive process to which peasant capacity for self-management was submitted would finally end up in a definitive loss of peasant autonomy.
Les journées rurales de Dijon en 1927. La Jeune République et les paysans
Authors: Vigreux Jean 
Published: February 2022

The 1927 "rural days" of Dijon. The "Jeune République" and the peasantry.
The "rural days" of Dijon, organized by the Jeune République in the spring of 1927, focussed on agricultural problems, but also on the various agrarian systems and types of crops, and on social and cultural questions, both in Burgundy and elsewhere in France, the topic depending on which representatives were present. These "rural days" are known thanks to a report written by the Italian Christian Democrat Guido Miglioli who attended these meetings. When he sent his report to the agrarian department of the Communist International (Krestintem), Guido Miglioli provided very accurate summaries of the statements put forward in Dijon, but above all he illustrated the fact that connections between the CI and other political movements could exist during the Bukarin era ; those connections would be brought to life again under the Popular Front.
Les communautés rurales en France. Définitions et problèmes (XVe-XIXe siècle)
Authors: Follain Antoine 
Published: February 2022

Rural communities in France : definitions and questions (XVth-XIXth century)
In the 1970s and 1980s, a synthesis of the study of rural communities in France was expected to be within reach. But research has increasingly focussed on some questions while neglecting others, such as politics. There have been few studies of the years 1450 to 1650, whereas the end of the Old Regime and the Revolution have attracted widespread interest ; similarly, parish communities (communautés paroissiales) were less studied than local communes (communautés municipales), which looked more like the municipal units created during the Revolution. There is still no synthesis for most regions, and there is a complete lack of comparative works. We do not have yet the necessary elements for such a work, which is difficult to undertake anyway since the topic under study is far from being clearly defined. Therefore this article is less a synthesis than a work aiming at raising questions of terminology (what does «village community», communauté villageoise, means ?), at warning historians against assessing the strength of a community from a strictly agrarian vantage point, at reasserting some of its basic structuring principles and at encouraging comparative studies even over a long period of time, while recalling at all times that a community is a place, a territory and a people all at once. It is hard to count rural communities : the 1789-1790 administrative redistricting into communes might be used as a basis, but nowhere was it accepted as final, and the first serious estimates can be worked out only for An II. The resilience of the network of communes and sections de communes throughout the XIXth century demonstrates the continued importance of localism, of the esprit de localité.
L’école au village aujourd’hui. Carte scolaire et monde rural
Authors: Lerch Dominique 
Published: February 2022

Village schools today. School districts and the rural world. Dominique Lerch
In the public mind, the school, just as much as the church spire, is an integral part of the village. However, for several decades now, each redistricting of the school system has reduced the weight of the one-classroom séhoolè, which were very often the only manifestation of State service in the villages. Having examined the process through which these schools are closed (number of pupils, minimum statutory threshold, but also parental choices and municipal investments in education), this paper sets out the constitutive elements underpinning a return to the one-room school, often managed by primary schoolteachers inspired by the Freinet method, and analyzes the recent debate sparked by various official reports (Mauger, Lebossé), stressing the complex nature of the choices faced, the diversity of the available responses, and the tensions which can be discovered in this area. The presentation of elements for a Europe-wide comparative approach may enrich the debate, which is also fed in a rather unexpected way by a «silent revolution » taking place at the level of the parish.
O processo de formulação dos indicadores de excelência da avaliação realizada nos cursos de pós-graduação stricto sensu elaborados pela CAPES / The formulation process of the excellence indicators of the assessment carried out in the stricto sensu graduate courses prepared by CAPES
Authors: Santos Ynara Victoria Borges , França Eliacir Neves 
Published: February 2022

No Brasil, os cursos de pós-graduação stricto sensu são avaliados pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) desde 1988 no âmbito do Sistema Nacional de Avaliação da pós-graduação (SNPG) com o fito de garantir a qualidade dos cursos de Mestrado e Doutorado no país. Portanto, a pesquisa tem como objetivo analisar como acontece o processo de formulação dos indicadores de excelência da avaliação realizada pela CAPES e, assim, contribuir com informações sobre o processo de avaliação dos cursos e programas de pós-graduação no país. A teoria que sustentou a análise dos dados dessa pesquisa foi aquela elaborada por Michel Aglietta no âmbito da escola francesa de regulação. Nossa hipótese foi que o processo de elaboração dos indicadores de excelência visa garantir a qualidade da formação oferecida para suscitar e motivar acordos internacionais e a criação de rankings. A metodologia utilizada para a coleta dos dados foi a pesquisa documental. Os dados foram coletados nos sítios do Ministério da Educação e da CAPES e tratou-se de documentos legais e relatórios. O instrumento de análise dos dados que utilizamos foi a análise de conteúdo na perspectiva de Lawrence Bardin. Esperamos, com os resultados dessa pesquisa, ampliar os conhecimentos acerca dos processos de avaliação conduzidos pela CAPES.
Inducción de estro en ovejas en lactación utilizando un antagonista opioide / Inducción de estro en ovejas en lactación utilizando un antagonista opioide
Authors: Fuentes-Hernández Víctor Octavio 
Published: February 2022

El objetivo de este fué estudio el efecto de un antagonista opioide sobre la presentación sincronizada de estro en ovejas lactantes. Se implantaron esponjas intra vaginales con MAP por una duración de 14 días. Al retirar la esponja se administraron 250 UI de eCG. Los grupos experimentales fueron medicados con 4 dosis de Naloxona 0.5 mg im cada 12 horas desde un día antes de sacar las esponjas. Se utilizó un carnero celador, y se realizó monta dirigida, tomado nota de la hora del procedimiento... Las ovejas que fueron sincronizadas con progestágenos eCG y naloxona presentaron estro y preñez significativamente más elevada que las borregas del grupo testigo de tal manera que de 15 ovejas sincronizadas se obtuvieron un total de 15 corderos entre los cuales 5 fueron machos y 11 hembras. En el grupo testigo se observó que 6/10 presentaron estro y parieron 5 crías. En el grupo de borregas Pelifolk se puede apreciar que existió un número de 30 crías al parto, con una presencia significativa (P 0.001) de partos dobles al comparar con los del grupo testigo. Se concluye que los Opioides endógenos son moduladores importantes de la reproducción y de la fertilidad en las ovejas.
Prevalência e infestação de ixodídeos em animais silvestres atropelados nas rodovias do interior paulista / Prevalence and infestation of ticks in6 wild animals injured on the roads in the São Paulo state, Brazil
Authors: Coelho William Marinho Dourado , Mateus Christiano Pavan , Bresciani Katia Denise Saraiva , Nogueira Fabio dos Santos , Gomes Cássia Regina de Avelar 
Published: February 2022

O objetivo deste estudo foi determinar a prevalência das espécies de ixodídeos presentes em animais silvestres atropelados ao longo das rodovias paulistas da região noroeste do estado de São Paulo. Carrapatos foram coletados de animais das espécies Hydrochoerus hydrochaeris, Euphractus sexcinctu, Nasua nasua, Cariama cristata, Chrysocyon brachyurus, Tapirus terrestris, Myrmecophaga tridactyla, Cerdocyon thous, Pecari tajacu, Didelphis albiventris, Mazama Americana, Alouatta caraya e Puma concolor. atropelados entre os anos de 2011 e 2019. Os carrapatos foram coletados e classificados de acordo com as suas características morfológicas. Foi observada ocorrência de Dermacentor (Anocentor) nitens (13,3%), Amblyomma cajennense (18,3%), Rhipicephalus (boophilus) microplus (41,6%) e Rhipicephalus sanguineus (26,8%) nos animais. Pode-se concluir com este estudo que a presença de carrapatos dos bovinos e caninos nas diferentes espécies estudadas evidencia a existência de áreas de sobreposição territorial entre os animais silvestres e domésticos, provavelmente como resultado da degradação ambiental, gerando riscos para os animais e também para o ser humano.
MODERN DIGITAL EDUCATIONAL ENVIRONMENT OF THE UNIVERSITY AS A FACTOR OF PROFESSIONAL TRAINING OF MASTERS OF PEDAGOGICAL EDUCATION
Authors: Везиров Т.Г. 
Published: February 2022

В статье рассматриваются некоторые составляющие современной цифровой образовательной среды вуза, которые оказывают помощь преподавателю организовать эффективный образовательный процесс магистратуры, осуществляющий подготовку магистров педагогического образования по магистерской программе «Информационные и коммуникационные технологии в образовании» при ФГБОУ ВО «Дагестанский государственный педагогический университет»
The article discusses some of the components of the modern digital educational environment of the university, which help the teacher to organize an effective educational process of the magistracy, which prepares masters of pedagogical education for the master’s program«Information and Communication Technologies in Education» at the FSBEI HE «Dagestan State Pedagogical University».