bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of site response function using Nakamura technique: A case study from Kumaun Himalaya.
Authors: PANDEY AUCHITYA KUMAR , Joshi Santosh , Upadhyay Rajeev , Pant Charu C. , Gupta Arun Kumar 
Published: March 2022

Abstract
The aim of this study is accomplished by utilizing the H/V spectral ratio method (Nakamura technique) to investigate the site response at fifteen seismic site stations. Regarding this method, some significant local site parameters such as the fundamental frequencies f 0 of soft sediments, peak amplitudes A 0 of corresponding H/V spectral ratios, spectrum amplitude, and spectrum rotation were computed over fifteen seismic stations in the study area. Microtremor data of fifteen seismic stations were utilized for site response. The fundamental frequency response varies from 0.67 to 8.10 Hz within the study area. Resulting from this analysis, the fundamental frequency response is low in and around the MUN, KLT seismic station. Similarly, the peak amplification at these seismic sites is found to be in the range of 2-4. Further, the contour map is prepared with the help of fundamental frequency response values obtained from the H/V curve to know the hazardous areas of the study region. Also, obtained H/V results were verified by comparing with SESAME guidelines condition of the study area. Spectrum rotation and spectrum amplitude analysis were carried out to know the characteristic of H/V with respect to azimuth and frequency in the sedimentary soil.
Validation Of Kyoto Classification Of Gastritis On Magnetic Controlled Capsule Endoscope
Authors: Xi Sun , Liu Jing , Lili Wu , Ming Wang , Zhiqiang Wang , Peng Jin , Li Tingting , Li Jun 
Published: March 2022

Abstract
Backgrounds: Previous studies showed that Kyoto classification of gastritis could accurately predict H. pylori infection status on conventional gastroscope. The aim of this study was to testify whether Kyoto classification of gastritis applies well on magnetic controlled capsule endoscopy (MCCE).Methods: This study included two phases, both of which were basically a group of diagnostic tests. In phase one which included 35 participants who had undergone both conventional gastroscope and MCCE, we testified whether major findings documented in Kyoto classification of gastritis could be well recognized on MCCE. Then, in phase two, we consecutively recruited 227 participants who had under gone both MCCE and urea breath test (UBT). The diagnosis of H. pylori infection status was independently made by 2 physicians who were blinded to UBT results and well versed in Kyoto classification of gastritis after reviewing MCCE images. Results: In phase one, all of the 10 findings selected from Kyoto classification of gastritis could be well recognized on MCCE, when findings on conventional gastroscope were used as the gold standard, the overall diagnostic accuracy, sensitivity and specificity were 96.6%, 84,7% and 100.0% respectively. In phase two, MCCE’s overall diagnostic accuracy on H. pylori infection status was 80.2%. The sensitivity, specificity and diagnostic odds ratio (DOR) for current-infection were 89.4%, 90.1% and 77.1 respectively. Major specific findings were mucosal swelling and spotty redness for current infection, regular arrangement of collecting venules (RAC), streak redness, fundic gland polyp (FGP) for non-infection, and map redness for past-infection.Conclusions: Kyoto classification of gastritis applied well on MCCE. H. pylori infection status could be accurately assessed on MCCE.
Circulating Osteocalcin is Associated with Time in range and other Metrics Assessed by Continuous Glucose Monitoring in Type 2 Diabetes
Authors: Liu Jun , Wei Yinghua , Zang Pu , Wang Wei , Feng Zhouqin , Yuan Yanyu , Zhou Hui , Zhang Zhen , Lei Haiyan , Yang Xinyi , Lu Bin , Shao Jiaqing , liu jun 
Published: March 2022

Abstract
Background:Osteocalcin is a sort of protein secreted by osteoblast exclusively，and new observations have verified that glucose balance can be modulated by it in some ways. TIR has attracted more and more attention as an emerging blood glucose evaluation index. In this study, the association between TIR and the level of circulating osteocalcin was investigated in type 2 diabetes.METHODS376 patients with type 2 diabetes were enrolled in our trail, all of them performed three consecutive days of monitoring. And they were divided into four groups on account of the quartile of osteocalcin. TIR, Time below range(TBR）, Time above range(TAR) and measures of glycemic variability (GV) were assessed for analysing. After a 100g standard steamed bread meal, blood glucose (Glu0h Glu0.5h, Glu1h, Glu2h, GLu3h), C-peptide (Cp0h, Cp0.5h, Cp1h, Cp2h, Cp3h), serum insulin (INS0h, INS0.5h, INS1h, INS2h, INS3h) concentrations at different time points were obtained. HOMA-IS, HOMA-β was calculated to evaluate insulin sensitivity and insulin secreting of the participants.RESULTSTIR increased significantly as the osteocalcin level increased between groups (p < 0.05). No significant differences were found in gender composition, age, weight, BMI, diabetes duration, K+, Ca+, Creatinine, blood pressure among groups (respectively, p>0.05). Osteocalcin had positive correlation with TIR (r=0.227, P<0.001), while a negative correlation was presented in osteocalcin and TAR (-0.229, P< 0.001). Likewise, osteocalcin was negatively correlated with INS0h, INS0.5h, fasting blood glucose and postprandial blood glucose at any time point after intaking of a standard meal.Meanwhile, osteocalcin had a negative correlation with the majority of GV indexes including standard deviation (SD), mean blood glouse (MBG), mean of daily differences (MODD), average daily danger range (ADDR). Multiple stepwise regression analysis demonstrated that osteocalcin was an independent contributor of TIR, TAR, and HOMA-IS.CONCLUSIONSCirculating osteocalcin has a positive correlation with TIR, and is an protective factor of TIR and insulin sensitivity in type 2 diabetic patients.
Design, Synthesis, and Biological Evaluation of Novel 2-Acetylphenol-Rivastigmine Hybrids as Potential Multifunctional Agents for the Treatment of Alzheimer’s Disease.
Authors: Deng Cong , Mi Jing , Zhou Yi , Li Xinjuan , Liu Zhengwei , sang zhipei , Li Hui 
Published: March 2022

Abstract
Herein, a series of 2-acetylphenol-rivastigmine hybrids were rationally designed as multifunctional agents for the treatment of AD through MTDLs strategy. The biological activity in vitro showed that compound 3c was a pseudo-irreversible and selective huAChE inhibitor ( IC50 = 8.7 µM). Compound 3c also showed potent MAO-B inhibitory activity with IC50 values of 2.9 µM. Moreover, compound 3c displayed selective metal chelation property, favourable drug-like property and good blood brain barrier permeability in vitro. Furthermore, compound 3c was a significant antioxidant with ORAC value of 1.2 eq and showed significant neuroprotective effect on H2O2-induced PC12 cells injury. Thus, compound 3c was a promising multifunctional agent for the treatment of AD.
Convalescent Plasma Treatment for SARS-CoV-2 Infected High-risk Patients - a Matched Pair Analysis to the LEOSS Cohort
Authors: Freise Noemi F. , Gliga Smaranda , Fischer Johannes , Lübke Nadine , Lutterbeck Matthias , Schöler Miriam , Bölke Edwin , Orth Hans M. , Feldt Torsten , Roemmele Christoph , Wilke Dominik , Schneider Jochen , Wille Kai , Hohmann Christian , Strauss Richard , Ruf Andreas , Schubert Joerg , Isberner Nora , Pilgram Lisa , Hanses Frank , Luedde Tom , Jensen Björn , Stecher Melanie , Hower Martin , Vehreschild Joerg J. 
Published: March 2022

Abstract
BackgroundEstablishing the optimal treatment for COVID-19 patients remains challenging. Specifically, immunocompromised and pre-diseased patients are at high risk for severe disease course and face limited therapeutic options. Convalescent plasma has been considered as therapeutic approach, but reliable data are lacking, especially for high-risk patients.MethodsWe performed a retrospective analysis of 55 hospitalized COVID-19 patients with high risk for disease progression, primarily due to immunosuppression from cancer, solid organ transplantation, autoimmune disease, dialysis. A matched-pairs analysis (1:4) was performed with 220 patients from the Lean European Open Survey on SARS-CoV-2-infected Patients (LEOSS) who were treated or not treated with convalescent plasma. ResultsBoth cohorts, had high mortality (UKD 41.8%, LEOSS 34.1%). A matched-pairs analysis showed no significant effect on mortality. CP administration before the formation of pulmonary infiltrates showed the lowest mortality in both cohorts (10%), whereas mortality in the complicated phase was 27.8%. CP administration during the critical phase revealed the highest mortality; UKD 60.9%, LEOSS 48.3%. ConclusionIn our cohort of SARS-CoV-2 infected patients with severe comorbidities CP did not significantly reduce mortality in a retrospective matched pairs analysis. However, our data supports the concept that a reduction in mortality is achievable when CP is administered early.
The Role of in-person Focus Groups in the Management of Urinary Incontinence in Women From a Mixed-methods, Randomized Pilot Study.
Authors: Toma Gina , Carolan Alexandra , Buckner-Petty Skye , Vargas Laura , Wolter Christopher , Khan Aqsa 
Published: March 2022

Abstract
Purpose: To assess the quantitative and qualitative components of in-person focus groups as a potential intervention for female patients with urinary incontinence.Methods: Women over the age of 18 seeking treatment for UI were randomized to standard care with focus group participation or to standard care alone. All participants completed validated questionnaires: MESA, UDI-6, OAB-SAT-q, PGI-S, PGI-I, SQoL-F, PHQ-9, IPAQ at the beginning and conclusion of the study. Questionnaires were analyzed with repeated measures of ANOVA models in an intention-to-treat manner. Three moderated focus group sessions were held and audio recorded. Recordings were transcribed and categorized by frequency into themes using grounded theory methodology. Results: A total of 10 control and 8 intervention participants agreed to participate. Seven women attended all three focus group sessions and were included in the final analysis. Transcripts from focus group sessions observed women identified most with (1) urinary incontinence (UI) as a chronic disease, (2) shame managing UI, and (3) social constraints of toileting. Participants self-reported appreciation of focus group participation and desire for on-going sessions. Analysis of the questionnaires did not demonstrate statistically significant differences.Conclusion: Data ascertained from questionnaires was unable to demonstrate a meaningful effect in improved treatment outcomes for control and intervention participants. Grounded theory analysis of transcripts identified four primary themes: (1) appreciation of the focus group, (2) UI as a gendered issue, (3) lack of public awareness, and (4) history of negative provider interactions. All focus group participants self-reported interest in attending future focus group sessions.
Can local environmental constraints improve enterprise's green innovation quality? Evidence from Chinese listed firms
Authors: Tang Yiding , Zhu Yuke , Gao Honggui , Hu Yanan , Ding Qinan 
Published: March 2022

Abstract
This study investigates how local environmental target constraints, a distinctive characteristic of Chinese environmental regulations, drive enterprises to improve their green innovation quality. We empirically examine the mechanism of the impact of the intensity of different types of local environmental target constraints on the quality of corporate green innovation utilizing the data of A-share listed companies in Shanghai and Shenzhen in China from 2011–2019 and each city’s Government Work Reports. First, the strength of indirect environmental target constraints has a significant positive effect on the quality of green innovation, but further nonlinear characteristics reveal a significant inverse U-shaped relationship between them. However, direct environmental target constraint intensity had significant effects in improving enterprises’ green innervation quality. Second, indirect environmental target constraint intensity has an inverted U-shaped trend in increasing the intensity of environmental regulation and influencing the digitalization of enterprises, which in turn forms an inverted U-shaped relationship with the quality of green innovation. Under indirect environmental goal constraint intensity, the increase in R&D expenditure for green innovation quality improvement decreases the expected net income, resulting in insufficient incentive for innovation, which explains the marginal decreasing trend of the positive impact of indirect environmental goal constraints on the quality of green innovation. Third, indirect environmental target constraint intensity works better in areas with policies prioritizing city over province and with mayors less than 57 years old. Therefore, local governments should establish an environmental target constraint system based on indirect environmental target constraints complemented by direct environmental target constraints, and assess and report the performance of indirect environmental targets in the subsequent Government Work Report. Further reforms should streamline administration, decentralize power and improve services, cultivate more young and knowledgeable cadres, encourage communication and exchange between governments and enterprises, and implement market-oriented environmental regulations and measures such as emission trading mechanisms.
Synthesis of high surface area zinc oxide supported copper catalysts and its catalytic activity studies on dehydrogenation of cyclohexanol
Authors: Koppadi Kumara Swamy , Nekkala Nagaraju , Ponnala Bhanuchander , SK Hussain , Seelam Prem Kumar , Perupogu Vijayanand , Balla Putrakumar 
Published: March 2022

Abstract
Rice-derived high surface area ZnO support (HSA-ZnO) is prepared by a novel thermal decomposition technique using rice grains as a sacrificial exo-template and zinc acetate trihydrate as an ZnO precursor. Further, copper supported HSA-ZnO catalysts with different copper loadings (4, 8, 12 and 16 wt.%) were prepared by using wet impregnation method and characterized by various physicochemical techniques such as X-ray diffraction (XRD), thermo gravimetric analysis (TGA), BET surface area, temperature programmed techniques for CO2 desorption (CO2-TPD) and reduction (H2-TPR) and N2O pulse chemisorption measurements. The as-prepared ZnO support material exhibited moderately high surface area of 145 m2/g, which is six times higher than commercial ZnO. The screening of Cu-modified HSA-ZnO catalysts were evaluated in the dehydrogenation of cyclohexanol to cyclohexanone reaction in a continuous flow reactor. In this work, the effect of temperature, the influence of copper loadings and the catalyst stability were thoroughly investigated. The catalyst exhibited varied properties with Cu loading and among the studied catalysts, 12 wt.% Cu/HSA-ZnO catalyst exhibited highest cyclohexanol conversion of 75% and 89% cyclohexanone selectivity was achieved. The results were substantiated and confirmed by N2O pulse chemisorption and temperature programmed studies.
Analysis of microstructural characteristics and components of red and yellow ink pigments used in permanent makeup
Authors: Jin Hyun Sook , Chang ByungSoo 
Published: March 2022

Abstract
Our purpose in this study is to analyze the microstructural characteristics and constituent elements of inorganic substances added to the yellow ink and red ink pigments used in permanent makeup. We observed the microstructural properties of inorganic pigments added to the ink using a scanning electron microscope (SEM) and analyzed the constituent elements of the inorganic pigment particles using an energy dispersion spectroscopy analyzer (EDS). In red wine-colored ink, cubic titanium dioxide with a diameter of 110 to 200 ㎚ was the major component, and rod-shaped iron oxide was rarely observed. Most of the ingredients of taupe yellow ink were rod-shaped yellow iron oxide, and a small amount of cubic titanium dioxide was observed. Red wine-colored ink and taupe yellow ink contained lumps composed of titanium dioxide particles. In red wine-colored ink, lumps were formed by agglomeration. However, we observed that the surface of the lump composed of titanium dioxide in the taupe yellow ink had a smooth surface caused by external physical compression. The titanium dioxide particle mass which found in taupe yellow ink in this study is an artificial product. When this mass accumulates in the dermis, it may cause a color mismatch. Therefore, permanent makeup using fine pigments should be free of foreign substances that may cause trouble in the skin. In addition, there is a need to improve the quality of the ink so that the required color can be safe and long lasting in the dermis.
Insights Into the Architecture of Human-induced Polygenic Selection in Duroc Pigs
Authors: Chen Zitao , Teng Jinyan , Diao Shuqi , Xu Zhiting , Ye Shaopan , Qiu Dingjie , Zhang Zhe , Pan Yuchun , Li Jiaqi , Zhang Qin , Zhang Zhe 
Published: March 2022

Abstract
Background
As one of the most utilized commercial composite boar lines, Duroc pigs have been introduced to China and undergone strongly human-induced selection over the past decades. However, the efficiencies and limitations of previous breeding of Chinese Duroc pigs are largely understudied. The objective of this study was to uncover directional polygenic selection in the Duroc pig genome, and investigate points overlooked in the past breeding process.
Results
Here, we utilized the Generation Proxy Selection Mapping (GPSM) on a dataset of 1,067 Duroc pigs with 8,766,074 imputed SNPs. GPSM detected a total of 5,649 putative SNPs actively under selection in the Chinese Duroc pig population, and the potential functions of the selection regions were mainly related to production, meat and carcass traits. Meanwhile, we observed that the allele frequency of variants related to teat number (NT) relevant traits was also changed, which might be influenced by genes that had pleiotropic effects. First, we identified the direction of selection on NT traits by \(\widehat{G}\), and further pinpointed large-effect genomic regions associated with NT relevant traits by selection signature and GWAS. Combining results of NT relevant traits-specific selection signatures and GWAS, we found three common genome regions, which were overlapped with QTLs related to production, meat and carcass traits besides “Teat number” QTLs. This implied that there were some pleiotropic variants underlying NT and economic traits. We further found that rs346331089 has pleiotropic effects on NT and economic traits, e.g., litter size at weaning (LSW), litter weight at weaning (LWW), days to 100 kg (D100), backfat thickness at 100 kg (B100), and loin muscle area at 100 kg (L100) traits.
Conclusions
The selected loci that we identified across methods displayed the past breeding process of Chinese Duroc pigs, and our findings could be used to inform future breeding decision.
Piperazine-modified magnetic graphene oxide (Pip@MGO) as a novel nanocomposite for the effective removal of lead ions; using RSM optimization
Authors: Alboghbeish Mousa , Saghanezhad Seyyed Jafar , Larki Arash 
Published: March 2022

Abstract
In this research, the piperazine-modified magnetic graphene oxide (Pip@MGO) nanocomposite was synthesized and utilized as a nano-adsorbent for the removal of Pb(II) ions from environmental water and wastewater samples. The physicochemical properties of Pip@MGO nanocomposite was characterized by XRD, FESEM, TEM, EDX, TGA, VSM and FT-IR analysis. In this method, the batch removal process were designed by response surface methodology (RSM) based on a central composite design (CCD) model. The results indicated that the highest efficiency of Pb(II) removal was obtained from the quadratic model under optimum conditions of prominent parameters (initial pH: 6.0, adsorbent dosage: 7 mg, initial concentration of lead: 15 mg L− 1 and contact time: 27.5 min). Adsorption data showed that lead ions uptake on Pip@MGO nanocomposite followed the Langmuir isotherm model equation and pseudo-second order kinetic model. High adsorption capacity (558.2 mg g− 1) and easy magnetic separation capability showed that the synthesized Pip@MGO nanocomposite has great potential in removal of Pb(II) ions from contaminated wastewaters.
Clinical traits and molecular genetics analysis of monogenic diabetes caused by mutations in the GATA6
Authors: Yue Xing , Huang Debin 
Published: March 2022

Abstract
Aim:This study aims to analyze the clinical and genetic features of monogenic diabetes with GATA6 mutations in order to improve clinicians’ understanding of the disease.Method:We report a de novo GATA6 mutation in a family and review related literature to summarize the clinical and genetic characteristics of monogenic diabetes with GATA6 mutations.Results:This GATA6 missense mutation(c.749G>T, p.Gly250Val) is not reported presently, characterized by adult-onset diabetes with pancreatic dysplasia and located in transcriptional activation region. Carries with GATA6 mutations(n=55) have a variable spectrum of dibetetes, ranging form neonatal(72.7%), childhood-onset(20%) to adults-onset(7.5%). 83.5% of patients with abmoral pancreatic development. Heart and hepatobillary defects are the most common abnormalities of extrapancreatic features. Most mutations with GATA6 are loss of function(LOF,71.8%) and located in functional region.Conclusion:The heterogeneous hallmarks result in monogenic diabetes with GATA6 mutations easy misdiagonsis and missed diagnosis. A comprehensive assessment and follow-up is needed in the clinic. Genetic counseling and genetic testing are recommended to patients with mutations.
EUD based 90Y-TOF-PET post selective internal radionuclide therapy provides a similar TCP in HCC than observed in EBRT
Authors: D'ABADIE philippe , Walrand Stephan , Hesse Michel , Borbath Ivan , Lhommel Renaud , Jamar François 
Published: March 2022

Abstract
Background: Tumor equivalent uniform dose (EUD) is a predictor of patient outcome after selective internal radionuclide therapy (SIRT) of hepatocellular carcinoma (HCC) and can be evaluated with 90Y-TOF-PET. The aim is to evaluate the correlation between PET based tumors EUD and the clinical response evaluated with dual molecular tracer (11C-acetate and 18F-FDG) PET/CT post SIRT. Methods: 34 HCC tumors in 22 patients were prospectively evaluated. The metabolic response was characterized by the Total Lesion Metabolism variation (ΔTLM) between baseline and follow up. This response allowed to compute a Tumor Control Probability (TCP) as a function of the tumor EUD. Results: The dose response correlation was exponential-asymptotic shaped and highly significant (R=0.72, P < 0.001). With a cutoff of 40Gy, the metabolic response was strongly different in both groups (median response 35% versus 100%, p< 0.001). Moreover, the TCP (EUD) was very similar to that observed in External Beam Radiation Therapy (EBRT). Conclusions: EUD based 90Y TOF-PET/CT predicts the metabolic response after SIRT of HCC assessed using dual molecular PET tracers and provides a similar TCP curve to that observed in EBRT. Both TCPs show that a EUD of 100 Gy is needed and sufficient to control a HCC.