bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myelitis: A Common Complication of Tuberculous Meningitis Predicting Poor Outcome
Authors: Jiang Yuxuan , Xu Xiangqin , Guo Zhuoxin , Liu Yuxin , Lin Jiahao , Suo Lijun , Jiang Ying , Liu Bo , Lu Tingting 
Published: March 2022

BackgroundMyelitis is an important complication in patients with tuberculous meningitis (TBM). However, a paucity of publications exists on the spectrum of neurological and MRI findings of TBM-related myelitis. The risk factors and prognosis of myelitis in patients with TBM are not fully understood. Therefore, this study aims to identify the risk factors, clinicoradiological features, and prognostic impact of myelitis for patients with TBM.MethodsWe conducted a retrospective study in our institution. Patients with TBM who were consecutively admitted during the period of August 2015 to December 2019 were included. We reviewed the demographic characteristics, clinical, laboratory and MRI findings, and clinical outcomes of all of the included patients. The diagnosis of myelitis was identified by a hyperintensity on T2-weighted images that were associated with cord edema, enlargement, and marginal or no enhancement on contrast-enhanced images.ResultsA total of 114 patients were included. Myelitis occurred in 19 (16.7%) patients, five of whom paradoxically developed myelitis. The common clinical signs of myelitis were paraparesis (738.9%), quadriparesis (844.4%), urinary retention or constipation (1,477.8%), and paresthesias in the lower limbs (1,052.6%). In the MRI findings, the hyperintensities on T2-weighted images involved more than 3 spinal cord segments. Myelitis was often combined with other forms of spinal cord injury, including 10 patients (52.6%) with spinal meningeal enhancement, 7 patients (36.8%) with enlargement of the central canal of the spinal cord, 6 patients (31.6%) with tuberculoma, and 4 patients (21.1%) with arachnoiditis and 1 patient (5.3%) with cerebrospinal fluid (CSF) loculations. None of the 5 patients with paradoxical myelitis were complicated with spinal meningeal enhancement and arachnoiditis, while 4 patients were complicated with enlargements of the central canal of the spinal cord. In multivariable analysis, a grade III disease severity on admission [p = 0.003, odds ratio (OR) = 8.131, 95% CI: 2.080–31.779] and high CSF protein (p = 0.033, OR = 1.698, 95% CI: 1.043–2.763) were independent risk factors for myelitis. After the 6 months follow-up, myelitis (p = 0.030, OR = 13.297, 95% CI: 1.283–137.812) and disturbance of consciousness (p = 0.042, OR = 12.625, 95% CI: 1.092–145.903) were independent risk factors for poor outcomes.ConclusionMyelitis was a common complication of TBM and independently predicted a poor outcome. A grade III disease severity and high CSF protein on admission were independent risk factors for myelitis. Paradoxical myelitis was rarely complicated with spinal meningeal enhancements and arachnoiditis, indicating that the immune reaction may play a dominant role.
Physical and Mental Aspects of Quality of Life in Patients With Charcot-Marie-Tooth Disease Type 1A
Authors: Ivanovic Vukan , Bjelica Bogdan , Palibrk Aleksa , Brankovic Marija , Bozovic Ivo , Basta Ivana , Savic Andrija , Stojanovic Vidosava Rakocevic , Kacar Aleksandra 
Published: March 2022

IntroductionCharcot-Marie-Tooth type 1A (CMT1A) comprises ~50% of all CMT cases. CMT1A is a slowly progressive motor and sensory neuropathy that leads to significant disability. We aimed to investigate the quality of life (QoL) in Serbian patients with CMT1A and to assess sociodemographic and clinical features associated with their QoL.Material and MethodsForty-five genetically confirmed patients with CMT1A were included −60% women [age 50.4 ± 12.6 years, disease duration 22 (12.5–31.5) years]. SF-36, Medical Research Council (MRC) Sum Score, CMT Examination Score (CMTES), Overall Neuropathy Limitation Scale (ONLS), Beck Depression Inventory (BDI), and Krupp's Fatigue Severity Scale (FSS) were used in the study.ResultsRegarding SF-36, Mental Health and Social Functioning were the scales with the best achievements, whereas Role Physical was the worst domain. Worse QoL in patients with CMT1A was associated with elder age (rho = −0.34, p &lt; 0.05), longer disease duration (rho = −0.31, p &lt; 0.05), more pronounced muscle weakness measured by MRC-SS (rho = 0.43, p &lt; 0.01), presence of tremor (p &lt; 0.05), worse CMTES (rho = −0.68, p &lt; 0.01), more severe disability in upper (rho = −0.70, p &lt; 0.01) and lower limbs (rho = −0.61, p &lt; 0.01) measured by ONLS scores, use of walking aids (p &lt; 0.01), and with depression (p &lt; 0.01) and fatigue (p &lt; 0.01). Worse scores on CMTES (beta = −0.43, p &lt; 0.01), BDI (beta = −0.39, p &lt; 0.01), and FSS (beta = −0.36, p &lt; 0.01) were significant independent predictors of worse QoL in patients with CMT1A (adjusted R2 = 0.77, p &lt; 0.001).ConclusionBesides impairment made directly by CMT1A itself, QoL in these patients was also strongly affected by the presence of depression and fatigue. Since CMT1A is still not a curable disease, it is of interest to identify factors associated with QoL that are amenable to treatment.
Breast Cancer Phenotype Associated With Li-Fraumeni Syndrome: A Brazilian Cohort Enriched by TP53 p.R337H Carriers
Authors: Sandoval Renata Lazari , Polidorio Natalia , Leite Ana Carolina Rathsam , Cartaxo Mariana , Pisani Janina Pontes , Quirino Carla Vanessa , Cezana Loureno , Pereira Natálya Gonçalves , Pereira Allan Andresson Lima , Rossi Benedito Mauro , Achatz Maria Isabel 
Published: March 2022

Breast cancer (BC) is the most prevalent malignancy in women with Li-Fraumeni syndrome (LFS). The literature on BC in LFS is limited due to its rarity worldwide. A TP53 founder pathogenic variant (c.1010G&gt;A; p.R337H) is responsible for the higher prevalence of this syndrome among women of Brazilian ancestry.PurposeThe aim of the study was to describe the BC phenotype expressed by Brazilian female LFS carriers and compare the data between p.R337H and other TP53 germline pathogenic/likely pathogenic variants (non-p.R337H carriers).MethodsWe searched for cases of TP53 germline pathogenic/likely pathogenic variant carriers affected by BC included between 2015 and 2020 in the BLiSS (Brazilian Li-Fraumeni Study) registry at the Sírio-Libanês Hospital.ResultsAmong 163 adult female carriers from the registry, 91 (56%) had received a BC diagnosis, including 72 p.R337H carriers. BC was the first cancer diagnosed in 90% of cases. Early onset BC (age ≤45 years) was diagnosed in 78.2% of cases (11.5% &lt;31 years; 66.7% 31–45 years; 21.8% &gt;45 years). The median age of BC diagnosis for p.R337H carriers was 39.5 years (range 20–69 years) compared to 34 years (range 21–63 years) for non-p.R337H carriers (p = 0.009). In total, 104 breast tumors were observed in 87 women. Bilateral BC was observed in 29.3% of cases. Histology was available for 96 tumors, comprising 69 invasive breast carcinomas, which were mostly invasive ductal carcinomas (95.6%), 25 ductal in situ carcinomas and 2 soft-tissue sarcomas. Overall, 90.5% of invasive breast carcinomas were hormone receptor (HR)-positive, 39.5% were human epidermal growth factor receptor 2 (HER2)-positive, and 32.8% showed HR and HER2 co-expression. In addition, 55.4% of patients opted for contralateral prophylactic mastectomy after a first BC diagnosis. There were no significant differences in the risk of developing contralateral BC or in the immunohistochemical profile between p.R337H and non-p.R337H groups.ConclusionsThe expressed phenotype of p.R337H is similar to that of other TP53 pathogenic/likely pathogenic variants, except for an average older age at the onset of disease; however, this is still younger than the general population.
Sleep Disturbances in Children Affected by Autism Spectrum Disorder
Authors: Galli Jessica , Loi Erika , Visconti Lucrezia Maria , Mattei Paola , Eusebi Anna , Calza Stefano , Fazzi Elisa ,   ASD Collaborative Group
Published: March 2022

BackgroundSleep disturbances are common in children affected by Autism Spectrum Disorder (ASD). The aim of our study was to describe sleep characteristics and disturbances in children with ASD, to evaluate possible related factors, and to assess parental stress.MethodsHundred children with a diagnosis of ASD (mean age: 66.7 months, SD: 27.4, range: 24.7–152.1 months, n = 79 males) were included in the study. We collected data on sociodemographic, clinical, genetic and instrumental variables as well as comorbid conditions. Parents filled out the Questionnaire on sleep behavior in the first years of life, the BEARS questionnaire, and the Parenting Stress Index Short Form. From the analysis on sleep characteristics, we excluded 25 children treated with melatonin.ResultsFifty-seven (57%) out of 100 children met the criteria for insomnia. Sleep disorders were associated with developmental or cognitive delay, emotional and behavioral problems (such as anxiety problems and aggressive behaviors) and absence of strategies for inducing sleep after nocturnal awakenings. From parents' reports, sleep disorders had diurnal repercussions on their offspring; however, we found no statistical correlation between disturbances and family stress. Also, no significant correlation was found between sleep disturbances and epilepsy. Finally, a statistical correlation was found between the regular intake of melatonin and the resolution of insomnia.ConclusionsMultifactorial variables may be associated to insomnia that could have an impact on the children' behavior. Clinicians need to be aware of the value of screening for sleep disturbance in children with ASD to integrate sleep interventions in the treatment plan.
A Year Through the COVID-19 Pandemic: Deleterious Impact of Hormonal Contraception on Psychological Distress in Women
Authors: Brouillard Alexandra , Davignon Lisa Marie , Fortin Justine , Marin Marie France 
Published: March 2022

BackgroundWomen are more at risk than men of suffering from psychological distress during disease outbreaks. Interestingly, no biological factors have been studied to explain this disparity in such contexts. Sex hormone variations induced by hormonal contraceptives (HC) have been associated with mental health vulnerabilities. However, most studies have examined current effects of HC without considering whether a chronic modulation of sex hormone levels could induce long-lasting effects that persist after HC cessation.ObjectivesTo date, the role of HC on psychological health in women during a disease outbreak is still unknown. We aimed to investigate both current and long-term effects of HC on psychological distress throughout the COVID-19 pandemic.MethodAt four time points during the COVID-19 pandemic (June 2020, September 2020, December 2020, March 2021), we collected self-reported data on psychological distress, assessing symptoms of post-traumatic stress [via the Impact of Event Scale-Revised (IES-R)], symptoms of depression, anxiety, and stress [via the Depression Anxiety Stress Scales (DASS-21)]. Linear mixed models were first used to compare men (n = 49), naturally cycling women (n = 73), and women using HC (n = 32) across time. To examine long-lasting effects of HC, exploratory analyses were restricted to women, comparing current HC users (n = 32), past users (n = 56), and never users (n = 17).ResultsThe first model revealed that women taking HC reported stable post-traumatic stress symptoms across time, compared to naturally cycling women and men who showed a significant decrease from T1 to T2. HC users also reported greater DASS-21 total scores over time. Moreover, HC users reported higher stress and anxiety symptoms than men. In the second model, results showed that past HC users had similar anxiety levels as current HC users. These two groups reported significantly more anxiety symptoms than never users.ConclusionHC users report increased distress during the pandemic relative to naturally cycling women and men. Our results also suggest a long-lasting effect of HC intake, highlighting the importance of considering both the current use of HC and its history. This could provide some insight into potential avenues for explaining why some women are prone to higher psychological distress than men.
The Forgotten (Invisible) Healthcare Heroes: Experiences of Canadian Medical Laboratory Employees Working During the Pandemic
Authors: Gohar Basem , Nowrouzi-Kia Behdin 
Published: March 2022

ObjectiveThe purpose of this qualitative study was to understand the stressors and coping strategies of medical laboratory technologists (MLTs) and assistants (MLAs) working during the COVID-19 pandemic in Ontario, Canada.MethodsIn this descriptive qualitative study, we held two focus groups with MLTs and MLA who were working during the COVID-19 pandemic. The focus group sessions were transcribed verbatim followed by thematic analysis to develop codes and themes.FindingsA total of 13 participants across Ontario were involved in our study, which included one MLT (n = 7) group and one MLA (n = 6) MLA. Overall, the stressors and coping methods identified between both focus groups were consistent. Our results revealed four main themes: (1) COVID-19 contributing to the notable and existing staff shortage; (2) the pandemic reinforced that medical laboratory employees are forgotten within the healthcare system; (3) a poor work environment exacerbated by the pandemic; and (4) a resilient and passionate group. Rich descriptions explained the underlying issues related to the themes.ConclusionsMLTs and MLAs are critical members of the healthcare team and provide vital patient care services. This study explored their experiences working during the pandemic and offers timely recommendations to mitigate against occupational stressors.
Influence of Hospital Outdoor Rest Space on the Eye Movement Measures and Self-Rating Restoration of Staff
Authors: Cui Weiyi , Li Zao , Xuan Xiaodong , Li Qingtao , Shi Lei , Sun Xin , Zhu Kai , Shi Yi 
Published: March 2022

ObjectiveTo investigate the effect of hospital outdoor rest space on the eye movement measures and self-rating restoration of staff.BackgroundRelieving the pressure of hospital staff through exposure to hospital outdoor rest space is essential, but there is a scarcity of research on the impact of hospital outdoor rest space on the eye movement measures and self-rating restoration of staff, especially for large Chinese hospitals.MethodsCross-analysis was conducted based on the eye movement measures of 76 staff members obtained by eye movement tracking equipment in combination with the self-rating restoration scale and hospital outdoor rest space picture attributes (element proportion and position, brightness and saturation).ResultsThe differences in eye movement measures of different staff attributes (occupation, age, and gender) were identified, and the effects of hospital outdoor rest space picture attributes on the eye movement measures and self-rating restoration scale of staff were summarized. A number of proposals were also formulated: hospital outdoor rest space should be set up close to the working area of the group of medical staff; attention should be paid to the actual needs of senior staff members and the work pressure of junior nurses; the exposure to natural environment should be increased and the proportion of hard artificial elements should be reduced; the natural environment should be placed in the visual center; the saturation and brightness of hospital outdoor rest space should be increased; and staff members should have access to the sky environment in a variety of ways.ConclusionThe present study is an empirical study of evidence-based design on hospital outdoor rest space in China, and the results reveal the effects of hospital outdoor rest space on the eye movement measures and self-rating restoration of staff.
Assessment of the Clinical Diagnosis of Onychomycosis by Dermoscopy
Authors: Ma Yan , Ji Ying , Cen Wen , Qiao Zusha , Gao Yan , He Lu , Feng Wenli 
Published: March 2022

BackgroundAs a common clinical superficial fungal infection, the diagnosis of onychomycosis relies on clinical features, traditional KOH direct microscopy and fungal culture. In recent years, dermoscopy has been widely used in the diagnosis and treatment of infectious diseases and has provided new options for the diagnosis of onychomycosis.ObjectiveTo evaluate the value of dermoscopy in the clinical diagnosis of onychomycosis and to explore the relationship between each clinical subtype and the dermoscopic pattern.MethodsA retrospective study of 114 cases of clinically suspected onychomycosis was conducted to compare the differences between dermoscopy and fungal pathogenic examination (microscopy and culture) in the diagnostic sensitivity of onychomycosis and to analyze the relationship between nine common dermoscopic modalities and clinical subtypes of onychomycosis.ResultsAmong the 114 proposed patients, 87 nails with positive fluorescent staining microscopy and/or positive fungal cultures were diagnosed as onychomycosis. The sensitivity and specificity of dermatoscopy, using the mycological findings as a reference, were 86.21 and 33.33%, respectively. The incidence of common dermatoscopic patterns in the 87 nails with confirmed onychomycosis was as follows: white flocculation in 76 cases (87.35%), longitudinal nail pattern in 72 cases (82.76%), jagged changes in the distal nail plate in 69 cases (79.31%) and yellow staining in 46 cases (52.87%), these four patterns were more commonly seen in the distal lateral subungual onychomycosis and total dystrophic onychomycosis, but there was no statistical difference in the positive dermatoscopic pattern between these two types (P &gt; 0.05).ConclusionDermoscopy can be an important aid in the diagnosis of onychomycosis, especially when fungal microscopy or culture is not appropriate, but this method is still not a substitute for fungal microscopy and culture.
BAUDRILLARD Y EL VACÍO DE LAS ARTES
Authors: Granados Valdéz Juan 
Published: March 2022

Este trabajo retoma el planteamiento de Jean Baudrillard para diagnosticar, entretejiendo la exposición de las ideas de este pensador francés con las consecuencias derivadas, la pérdida del carácter simbólico en el arte. Se ha encontrado en él una propuesta que intenta dar cuenta de la cultura reciente y de las artes en este sentido. Aunque se tienen en cuenta los estudios sobre la imagen, el arte y el simulacro de Adolfo Vázquez Rocca sobre Baudrillard, se desglosan las precisiones conceptuales de la teoría, siguiendo las contraseñas de Baudrillard, lo que dice de la situación de las artes y la pérdida de su carácter simbólico. Ante esta situación se abren preguntas para exploraciones siguientes: ¿por qué y para qué retornar al símbolo y a lo oculto si ya impera lo transparente?, ¿qué consecuencias tiene no dejar nada oculto en la sociedad y la cultura?, ¿es cierto que todo es obsceno y fascinante?, ¿tiene solución la enfermedad? Las respuestas a estas cuestiones no se encontrarán en Baudrillard y, según se ve, tampoco una cura.
PALABRAS CLAVE: Símbolo; objeto; simulacro; imagen; arte.
BAUDRILLARD AND THE VACUUM OF THE ARTS
ABSTRACT
This paper takes up the approach of Jean Baudrillard to diagnose, interweaving the exposition of the ideas of this French thinker with the derived consequences, the loss of symbolic character in art. It has found in him a proposal that tries to give account of the recent culture and the arts in this sense. Although the studies on the image, the art and the simulation of Adolfo Vázquez Rocca on Baudrillard are taken into account, the conceptual precisions of the theory are broken down, following the passwords of Baudrillard, what it says of the situation of the arts and the loss of its symbolic character. Faced with this situation open questions for subsequent explorations: why and why return to the symbol and the hidden if the transparent already prevails? What are the consequences of not leaving anything hidden in society and culture? Is it true that everything Is it obscene and fascinating? Does the disease have a solution? The answers to these questions will not be found in Baudrillard and, as you can see, neither will a cure.
KEYWORDS: Symbol;object; simulacrum; image; art.
Detection of female volleyball player body composition uzing bioelectric impedanse analysis: cross-sectional study
Authors: Pavlović Ratko , Savić Vladan , Radulović Nikola , Skrypchenko Iryna 
Published: March 2022

Purpose: In today's sport, and especially in high-performance sports where volleyball also belongs, continuous monitoring of Body Composition (BC) can significantly regulate the training process, which has a positive effect on the top form of athletes. Aim of the current study was to assess and analyze the body composition of a female volleyball players VC "Jahorina", by Bioelectric Impedance Analysis (BIA). Material and methods: In study the participants consist 18 female volleyball players, the members of the Volleyball Club ''Jahorina'' from Pale, East Sarajevo City (Body height = 173 ± 8.77 cm; Body weight = 66.04 ± 9.09kg; BMI = 22.03 ± 2.19 kg/m², decimal age 19.11 ± 2.63 years old) who competes in the Premier League of Bosnia and Herzegovina (B&H). Results: of the study showed that the body composition is within the healthy (allowed) values recommended for this population of volleyball players (Body Fat = 24.82%; Body Fat=11.44kg; Body Water = 53.68%; Body Muscle = 47.09 kg, BMR = 1538.08; DCI = 6435.38, etc.). Conclusion: Compared to the results of other authors, that Jahorina volleyball players do not lag far behind European clubs in terms of weaker BC (BF%, BFkg, BW%, BMkg, BMR, DCI, BMI, etc.). The only place where they are inferior is the body height of the volleyball player (height = 173 ± 8.77 cm), while the relative value of Body weight = 66.04 ± 9.09 kg is evident.
APPROACH TO SUBSTANTIATE THE STRATEGIC DIRECTIONS FOR THE DEVELOPMENT OF ITU FOR THE PERIOD 2024-2027 USING SWOT ANALYSIS
Authors: РЕЗНИКОВА Н.П. , АРТЕМЬЕВА Г.С. 
Published: March 2022

Представлены результаты стратегического анализа возможных направлений развития Международного союза электросвязи (МСЭ) после Полномочной конференции 2022 г. (на период 2024-2027 гг.). С помощью метода SWOT-анализа выявлены основные сильные и слабые стороны МСЭ, а также возможности и главные угрозы для Союза в рассматриваемой перспективе. К моменту завершения данного исследования Рабочая группа Совета мСэ по стратегическому и финансовому планированию (РГС-СФП) опубликовала первую, частичную, версию Стратегического плана МСЭ на 2024-2027гг. Проверка этой первоначальной версии на соответствие предложениям, изложенным в статье, приводит к выводу о возможности и целесообразности ее дальнейшего развития - при условии, что она будет принята на Совете МСЭ в 2022 г., так как предложения РГС-СФП укладываются в рамки выявленных авторами стратегических направлений развития Союза.
The results of a strategic analysis of possible directions for the development of the International Telecommunication Union (ITU) after the 2022 Plenipotentiary Conference (for the period 2024-2027) are presented. Using the SWOT analysis method, the main strengths and weaknesses of the ITU, as well as the opportunities and main threats for the Union in the considered perspective, have been identified. By the time this study was completed, the ITU Council Working Group for Strategic and Financial Plans 2024-2027 (CWG-SFP) had published the first partial version of the ITU Strategic Plan. Checking this initial version for compliance with the proposals outlined in the article leads to the conclusion about the possibility and expediency of its further development -provided that it is adopted by the ITU Council in 2022 since the CWG-SFP proposals fit into the framework of the strategic directions of development of the ITU identified by the authors.