bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal Timing of Ovulation Triggering to Achieve Highest Success Rates in Natural Cycles—An Analysis Based on Follicle Size and Oestradiol Concentration in Natural Cycle IVF
Authors: Helmer Anja , Magaton Isotta , Stalder Odile , Stute Petra , Surbek Daniel , von Wolff Michael 
Published: May 2022

IntroductionTiming of ovulation triggering is essential in infertility treatments including treatments based on natural menstrual cycles. However, data on follicle size and oestradiol (E2) concentration are limited. Therefore, the model of natural cycle IVF (NC-IVF) was applied to provide more detailed information on these parameters to better schedule the optimal time for triggering ovulation.Materials and MethodsA retrospective cross-sectional analysis of 606 monofollicular NC-IVF cycles was performed at a university-based IVF centre from 2016 to 2019. Follicle size and E2 and LH serum concentrations were evaluated on day -5 to 0 (day 0 = day of oocyte retrieval). Ovulation was triggered if follicle size was 14–22 mm. Patients with irregular cycles, endometriosis &gt;II°, cycles with azoospermia or cryptozoospermia and cycles with inconsistent data were excluded. All parameters were analysed inter- and intraindividually, and associations of the parameters were evaluated. Associations were adjusted for age, cause of infertility and number of previous transfers.ResultsThe mean age of women undergoing NC-IVF was 35.8 ± 4.0 years. Follicle size increased by 1.04 ± 0.03 mm, and E2 concentration by 167 ± 11.0 pmol/l per day.Based on a multivariate adjusted mixed model with follicle size, E2 and their interaction, the number of retrieved oocytes was associated with E2 concentration (aOR 1.91, 95% CI: 1.03–3.56; p = 0.040). Maturity of oocytes was associated not only with E2 concentration (aOR 2.01, 95% CI: 1.17–3.45; p = 0.011) but also with follicle size (aOR 1.27, 95% CI: 1.01–1.60; p = 0.039), as was the interaction of both parameters (aOR 0.96, 95% CI: 0.93–0.99; p = 0.017).LH surge was calculated to start in 25% of cases at an E2 level of 637 pmol/l, in 50% of cases at 911 pmol/l and in 75% of cases at an E2 level of 1,480 pmol/l.The live birth rate per follicle aspiration cycle was (non-significantly) higher in cycles with follicles sizes at the time of oocyte retrieval of 18–22 mm (7.7%–12.5%) versus in cycles with follicles sizes of 14–17 mm (1.6%–4.3%).ConclusionThe study contributes to an optimization of infertility treatments involving natural cycles. The study gives guidance about the number of days required after follicle monitoring to schedule the optimal time for triggering ovulation.
Grapefruit Juice Flavanones Modulate the Expression of Genes Regulating Inflammation, Cell Interactions and Vascular Function in Peripheral Blood Mononuclear Cells of Postmenopausal Women
Authors: Krga Irena , Corral-Jara Karla Fabiola , Barber-Chamoux Nicolas , Dubray Claude , Morand Christine , Milenkovic Dragan 
Published: May 2022

Grapefruit is a rich source of flavanones, phytochemicals suggested excreting vasculoprotective effects. We previously showed that flavanones in grapefruit juice (GFJ) reduced postmenopausal women’s pulse-wave velocity (PWV), a measure of arterial stiffness. However, mechanisms of flavanone action in humans are largely unknown. This study aimed to decipher molecular mechanisms of flavanones by multi-omics analysis in PBMCs of volunteers consuming GFJ and flavanone-free control drink for 6 months. Modulated genes and microRNAs (miRNAs) were identified using microarrays. Bioinformatics analyses assessed their functions, interactions and correlations with previously observed changes in PWV. GFJ modified gene and miRNA expressions. Integrated analysis of modulated genes and miRNA-target genes suggests regulation of inflammation, immune response, cell interaction and mobility. Bioinformatics identified putative mediators of the observed nutrigenomic effect (STAT3, NF-κB) and molecular docking demonstrated potential binding of flavanone metabolites to transcription factors and cell-signaling proteins. We also observed 34 significant correlations between changes in gene expression and PWV. Moreover, global gene expression was negatively correlated with gene expression profiles in arterial stiffness and hypertension. This study revealed molecular mechanisms underlying vasculoprotective effects of flavanones, including interactions with transcription factors and gene and miRNA expression changes that inversely correlate with gene expression profiles associated with cardiovascular risk factors.Clinical Trial Registration[ClinicalTrials.gov], identifier [NCT01272167].
Inhibitory Effects of Donkey Hide Gelatin on DNCB-Induced Atopic Dermatitis in NC/Nga Mice
Authors: Lee Ju Hyun , Dong Linsha , Noh Hyeon Min , Park Sung-Gu , Kim Seung-Hyung , Jo Eun Heui , Lee Dong-Sung , Park Min Cheol 
Published: May 2022

The increase of atopic dermatitis has led to higher socio-economic cost and raised a need for alternative medicine as novel therapeutic agents. In this study, we aimed to evaluate the inhibitory effects of Donkey Hide Gelatin (DHG) water extract on DNCB-induced atopic dermatitis in NC/Nga mice and on tumor necrosis factor (TNF)-α/interferon (IFN)-γ-treated keratinocytes and to investigate its underlying molecular mechanisms. NC/Nga mice were induced by DNCB, administered Dexamethasone (3 mg/kg) or DHG water extracts (100–400 mg/kg) for 3 weeks. The skin symptom score, serum IgE and immune cells were measured, the ALN, spleen and dorsal skin tissue were extracted for FACS, quantitative real-time PCR and histology analysis.In vitro, HaCaT cells were induced by TNF-α/IFN-γ, the levels of pro-inflammatory cytokines and chemokines and its underlying mechanism were measured by ELISA and Western blot. As a result, DHG groups showed a significant decrease in the skin symptom score and the immune cell absolute number. It also showed a marked reduction of allergic and the levels of neutrophils and eosinophils in histology analysis. In TNF-α/IFN-γ induced HaCaT cells, DHG showed inhibition effects on IL-6, IL-8, TARC and RANTES, it also downregulated the expression of ICAM-1 and COX-2, up-regulated the expression of Filaggrin. Furthermore, DHG suppressed the activation of NF-κB and mitogen-activated protein kinases (MAPK) signaling pathway induced by TNF-α/IFN-γ. Taken together, DHG maybe a potential therapeutic agent or supplement for skin inflammatory disease such as atopic dermatitis.
Textual Features and Risk Preference Effects on Mental Health Education Among Teenager Students in Chongqing, China
Authors: Jiang Mengyao , Zhang Zuyue , Kang Li , Liao Jing , Wang Shumin , Lv Yalan , Zhou Xiaoyu , Hou Xiaorong 
Published: May 2022

BackgroundMental health is a public health problem of great concern. Previous studies show that textual features and individual psychological characteristics can influence the effect of receiving information.PurposeThis study explores whether textual features influence the persuasiveness of teenager students’ mental health education while considering the influence of risk preference.MethodsFrom November to December 2021, a cross-sectional study was conducted among 1,869 teenager students in grade 7–12 in Chongqing, China. Wilcoxon signed-rank test, multiple logistic regression, and subgroup analysis were used to analyze the data.ResultsAmong the four textual features mentioned in this study, a significant difference was reported in the persuasive effects of information with and without numerical features (p &lt; 0.001), and such information tended to include digital features. The result for the symbolic features (p &lt; 0.001) was consistent with the numerical features. The persuasive effects of positive and negative emotional information significantly differed (p &lt; 0.001), with the former showing a better performance. No significant differences were observed between the persuasive effects of information with and without emotional conflicts (p &gt; 0.05). Combined with those from the risk preference analysis, results showed that the regulatory effect of risk preference was only reflected in emotional conflicts. Students who prefer having no emotional conflict in the text showed the characteristics of risk avoidance, or lower grades, or rural or school accommodation. Most teenager students are also risk averse, especially females (or = 2.223, 95%CI:1.755–2.815) and juniors (or = 1.533, 95%CI: 1.198–1.963).ConclusionThe numbers, symbols, and positive emotions in the text generate an active effect on teenager students receiving mental health education. Students avoiding risk are inclined to read texts without emotional conflicts. The probability of male choosing texts with positive emotional polarity is 33.5% lower than that of female. Female students and those from lower grades also demonstrate a higher inclination to risk avoidance compared with their male and higher grade counterparts. Therefore, educational materials with different text characteristics should be developed for teenager students with varying characteristics.
Palliative Psychiatry for Patients With Severe and Persistent Mental Illness: A Survey on the Attitudes of Psychiatrists in India Compared to Psychiatrists in Switzerland
Authors: Stoll Julia , Mathew Anju , Venkateswaran Chitra , Prabhakaran Anil , Westermair Anna Lisa , Trachsel Manuel 
Published: May 2022

ObjectivesPalliative psychiatry is a new approach for the care of patients with severe and persistent mental illness (SPMI) which systematically considers biological, psychological, social, and existential factors of care. To assess the attitudes of psychiatrists in India toward palliative psychiatry for patients with SPMI and to compare these to the attitudes of psychiatrists in Switzerland.MethodsIn an online survey, data from 206 psychiatrists in India were collected and compared with data from a previous survey among 457 psychiatrists in Switzerland.ResultsPsychiatrists in India generally considered it very important to prevent suicide in SPMI patients (97.6%). At the same time, they considered it very important to reduce suffering (98.1%) and to ensure functionality in everyday life (95.6%). They agreed that palliative psychiatry is important for providing optimal care to SPMI patients without life-limiting illness (79.6%) and considered palliative psychiatry as indicated for patients with SPMI (78.2%). By contrast, curing the illness was considered very important by only 39.8 % of respondents. Relative to psychiatrists in Switzerland, psychiatrists in India were significantly more concerned about preventing suicide and less willing to accept a reduction in life expectancy, even at the expense of quality of life in patients with severe and persistent schizophrenia and recurrent major depressive disorder. At the same time, they were significantly more likely to advocate palliative psychiatry.ConclusionMost of the participating psychiatrists in India agreed that palliative psychiatry can be indicated for patients with SPMI. The comparison with psychiatrists in Switzerland highlights the need to take account of cultural differences in future studies of this kind. In summary, this study shows the potential of palliative psychiatry as a genuine biopsychosocio-existential approach which systematically integrates biological, psychological, social, and existential factors of care.
Influence of Identity Development on Weight Gain in Adolescent Anorexia Nervosa
Authors: Budde Lynn I. , Wilms Simon , Föcker Manuel , Dalhoff Anke , Müller Joerg M. , Wessing Ida 
Published: May 2022

BackgroundAnorexia Nervosa (AN) typically begins during early adolescence, an important phase of personality development. A substantial proportion of adolescent AN patients shows impaired personality functioning, which might be a relevant but understudied aspect of illness severity. The developmental status of identity as key element of personality is suggested to influence inpatient treatment outcome in adolescents with AN.MethodsThis study analyzed existing data of N = 60 adolescents with AN. Multilevel models assessed the influence of identity functioning, measured by the Assessment of Identity Development in Adolescence (AIDA) at admission, on weight gain [BMI (body mass index), BMI-SDS (BMI standard deviation score)] during 10 weeks of inpatient treatment. Moreover, the influence of other indicators of illness severity, i.e., eating disorders and comorbid psychopathologies, was explored.ResultsAs expected, higher AIDA scores negatively influenced the course of weight gain. A similar effect was observed for other psychopathology measures, especially body image distortion. In general, higher weight at admission was associated with less weight gain. Higher weight at admission was also predicted by higher other psychopathology measures, but not AIDA scores.ConclusionThe course of weight gain during inpatient treatment was hampered in adolescent AN patients who have difficulties developing a stable identity. Unlike other aspects of psychopathology, this was independent of the initial weight. Thus, in addition to the level of underweight and other aspects of psychopathology, difficulties in identity development constitute a relevant aspect of illness severity in AN. This recommends consideration of identity development during treatment.
Entre a pistis e o logos
Authors: Silva Gilvan Ventura da 
Published: May 2022

Neste artigo, temos por objetivo refletir sobre a aproximação entre a pistis (crença) e o logos (razão) que começa a se aprofundar na época imperial, em boa parte devido ao trabalho de autores como Fílon de Alexandria e Nigídio Fígulo, quando ambos passam a colocar a filosofia a serviço da religião, tendência que se afirmará no decorrer dos séculos posteriores até encontrar a sua forma mais bem acabada em Jâmblico, um filósofo neoplatônico que se notabilizará não apenas como filósofo, mas também como hierofante e, mais que isso, como teurgo, ou seja, feiticeiro. Por esse motivo, talvez não seja exagero afirmar que, no pensamento de Jâmblico, filosofia e religião praticamente se confundem, num momento em que os deuses ancestrais de gregos, romanos, egípcios, fenícios e tantos outros povos eram alvo de severos ataques desferidos pelos cristãos, que buscavam instaurar um novo mundo depurado da “impiedade” pagã.
auxilia palatina e a sua utilização em combate no século IV da nossa era
Authors: Janniard Sylvain 
Published: May 2022

As auxilia palatina constituem uma categoria nova e especial de unidades de primeira linha no exército romano tardio. Seu recrutamento inicial poderia ter sido realizado tanto entre as populações provinciais, em particular do noroeste do império, quanto entre os povos germânicos que permaneceram fora deste último ou parcialmente admitidos em seu solo; os órgãos complementares e auxiliares do exército romano também poderiam ter servido de base para a constituição da primeira auxilia. Formalmente instituídas durante o período tetrárquico, após uma fase de gênese nos exércitos que acompanham os príncipes, provavelmente iniciada no segundo terço do século III, as auxilia são formações de infantaria com número limitado, e das quais a maior parte se juntou, sob Constantino à categoria militar privilegiada dos palatinos. Dessa forma, o objetivo desse artigo é mostrar as novas intençõe táticas desse grupo específico do exército romano.
“Busca a sabedoria e (...) ela te cercará com seus braços ”
Authors: Aso Graciela Gómez 
Published: May 2022

O objetivo deste trabalho é estudar o bispo cristão Jerônimo, de grande fama intelectual, e sua estreita relação religiosa e cultural com um grupo de mulheres romano-cristãs conhecido como “círculo aventino”.
É importante notar que o cristianismo reconfigurou o modelo feminino. As mulheres cristãs eram valorizadas por sua livre escolha de manter a abstinência sexual mais ou menos perpétua ou o modelo de virgindade como o mais alto grau de liberdade de escolha das jovens sobre o uso sexual de seus corpos. Essa atitude das mulheres cristãs as colocou à margem dos padrões socioculturais ligados à obrigação de toda mulher romana de colocar sua condição de mãe antes de sua condição de mulher com livre escolha sobre seu corpo.
Entre o final do século IV e o início do século V, no meio das mulheres aristocráticas do Aventino, Jerônimo foi o executor de uma tarefa que seria de fundamental importância no desenvolvimento da ascese monástica em Roma. O bispo de Belém chamou essas mulheres aristocráticas de seu meio de monachaechristianae (freiras cristãs). Mulheres que mesmo em Roma decidiram viver com otimismo sua rigorosa ascese e sua virgindade como padrão de conduta cristã diante dos demais membros da comunidade cristã e da sociedade em geral. As virgens, em particular, foram treinadas para dar-se um espaço de leitura sagrada que as aproximava de um novo e transgressor modelo de conhecimento diante das normas educacionais romano-pagãs.
PEMODELAN MESIN PENCACAH JAGUNG MENGGUNAKAN PETRI NET
Authors: Murdianto Deny , Santoso Dwi 
Published: May 2022

AbstractThe chopper is a machine that is widely used to assist agricultural product processing activities, the most common problem is that the chopper machine will experience a decrease in efficiency if it is used frequently or the machine has passed a service life of more than three years. Another thing that often happens is that the main driving components, namely the dynamo, pulley, v-belt and chopper, wear out so that the efficiency of the engine decreases. Modeling using the petri net method aims to understand the dynamics that occur in the chopper. The chopper is said to be good in this modeling if it does not experience deadlocks and there are no long queues. The resulting Petri Net consists of four places and five transitions. Each place and transition describes the dynamics of the chopper. The transition is a critical transition which, if enabled and fired, will cause the engine to turn off and make the queue to be chopped more and more. This happens because the initial assumption that is built requires that every enable transition will be immediately fired, namely the .Key words: Petri Net, Chopping Machine, ModelingAbstrakMesin pencacah merupakan suatu mesin yang banyak digunakan untuk membantu kegiatan pengolahan hasil pertanian, permasalahan yang banyak terjadi yaitu mesin pencacah akan mengalami penurunan efisiensi jika sering dipakai atau mesin tersebut sudah melawati masa pakai di atas tiga tahun. Hal lain yang sering terjadi yaitu komponen penggerak utama yaitu dynamo, pulley, v-belt dan chopper mengalami keausan sehingga efisiensi mesin mengalami penurunan. Pemodelan dengan menggunakan metode petri net bertujuan untuk memahami dinamika yang terjadi pada mesin pencacah. Mesin pencacah dikatakan baik pada pemodelan ini jika tidak mengalami deadlock dan tidak terdapat antrian yang panjang. Petri Net yang dihasilkan terdiri dari empat place dan lima transisi. Masing-masing place dan transisi menggambarkan dinamika pada mesin pencacah. Transisi menjadi transisi kritis yang apabila enable dan difire akan mengakibatkan mesin off serta membuat antrian yang akan dicacah menjadi semakin banyak. Hal ini terjadi karena asumsi awal yang dibangun mengharuskan setiap transisi enable akan langsung difire, yaitu transisi .Kata kunci: Mesin Pencacah, Pemodelan, Petri Net
ANALISIS PETANI JAGUNG DALAM MEMANFAATKAN SARANA PRODUKSI DI DESA PILOMONU KECAMATAN MOOTILANGO KABUPATEN GORONTALO
Authors: Gobel Yusriyah Atikah , Djibran Moch. Muchlis , Djamil Abdul Kadir G. 
Published: May 2022

ABSTRACTThe purpose of this study was to determine the production facilities used by corn farmer groups and the behaviour of farmer group members in utilising production facilities in Pilomonu village, Mootilango district, Gorontalo district. The results showed that the production facilities used by farmer groups in Pilomonu Village, Mootilango Subdistrict, were considered very good, namely the use of superior seeds could increase productivity. Seeds were the decisive stage in the entire cycle of agricultural activities. The dose, time, and method of using fertilisers affected the productivity of corn plants. OPTs and pests can reduce the productivity of agricultural crops. The need for pesticides must be in accordance with the area of land planted. The dose, time, and method of using pesticides affect the productivity of corn plants. Recognizing signs of plants that are lacking sufficient excess pesticides is knowledge that must be owned by farmers. Agricultural mechanisation can increase farm productivity. Seeds, fertilizers, pests and pesticides, as well as agricultural mechanization, are good for increasing corn production facilities in Pilomonu VillageKey words: Behavior, Corn , Farmers, Means Of Production.ABSTRAKTujuan penelitian ini adalah untuk mengetahui sarana produksi yang dimanfaatkan kelompok tani jagung dan perilaku anggota kelompok tani dalam memanfaatkan sarana produksi di desa Pilomonu Kecamatan Mootilango Kabupaten Gorontalo. Dari hasil penelitian menunjukkan bahwa sarana produksi yang dimanfaatkan kelompok tani di Desa Pilomonu Kecamatan Mootilango yang dianggap sangat baik yaitu penggunaan benih unggul dapat meningkatkan produktivitas, benih merupakan tahap menentukan dalam seluruh siklus kegiatan pertanian, dosis, waktu dan cara penggunaan pupuk berpengaruh terhadap produktivitas tanaman jagung, OPT/hama dapat menurunkan produktivitas tanaman pertanian, kebutuhan pestisida harus sesuai dengan luas lahan yang ditanami, dosis, waktu dan cara penggunaan pestisida berpengaruh terhadap produktivitas tanaman jagung, mengenali tanda-tanda tanaman yang kurang, cukup, kelebihan pestisida merupakan pengetahuan yang harus dimiliki petani dan mekanisasi pertanian dapat meningkatkan produktivitas usahatani.Benih, pupuk, OPT dan pestisida serta mekanisasi pertanian tergolong baik untuk meningkatkan sarana produksi tanaman jagung di Desa Pilomonu.Kata kunci: Jagung, Perilaku, Petani, Sarana Produksi.
Complicaciones postquirúrgicas en neonatos con atresia esofágica
Authors: Corado Carrillo Inés Esthefany 
Published: May 2022

OBJETIVO: describir las complicaciones postquirúrgicas en neonatos con atresia esofágica. MÉTODO: se recopiló información en Pubmeed, revistas científicas, libros, metaanálisis, artículos y guías sobre atresia esofágica y complicaciones postquirúrgicas. RESULTADOS: en los neonatos con atresia esofágica predomina el sexo masculino y una edad promedio de 1 a 2 días de vida en el momento de la intervención quirúrgica. Se describe que las complicaciones postquirúrgicas más frecuentemente presentadas son dehiscencia de la anastomosis esofágica, neumonía, fuga de la anastomosis, aspiración pulmonar recurrente, reflujo gastroesofágico, disfagia, recurrencia de la fistula, estenosis, esofagitis y sepsis. Los principales factores asociados a mortalidad del neonato postquirúrgicamente de atresia esofágica el shock séptico, neumonía y broncoaspiración. CONCLUSIÓN: a pesar de la excelente gestión quirúrgica y neonatal, estudios recientes han reportado que las tasas de complicaciones postoperatorias oscilan entre el 20 y el 60% teniendo un impacto significativo en el pronóstico de los pacientes con atresia esofágica, y se pueden asociar con resultados desfavorables.