bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial and Socioeconomic Differences in Distance Traveled for Elective Hip Arthroplasty
Authors: Orringer Matthew , Roberts Heather , Ward Derek 
Published: April 2022

Introduction:
There are data that disparities exist in access to total hip arthroplasty (THA). However, to date, no study has examined the relationship between distance traveled to undergo THA and patient demographic characteristics, such as race, insurance provider, and income level as well as postoperative outcomes.

Methods:
Data from the Healthcare Cost and Utilization Project, American Hospital Association, and the United States Postal Service were used to calculate the geographic distance between 211,806 patients' population-weighted zip code centroid points to the coordinates of the hospitals at which they underwent THA. We then used Healthcare Cost and Utilization Project data to examine the relationships between travel distance and both patient demographic indicators and postoperative outcomes after THA.

Results:
White patients traveled farther on average to undergo THA as compared with their non-White counterparts (17.38 vs 13.05 miles) (P < 0.0001). Patients with commercial insurance (17.19 miles) and Medicare (16.65 miles) traveled farther on average to receive care than did patients with Medicaid insurance coverage (14.00 miles) (P = 0.0001). Patients residing in zip codes in the top income quartile traveled farther to receive care (18.73 miles) as compared with those in the lowest income quartile (15.31 miles) (P < 0.0001). No clinically significant association was found between travel distance and adverse postoperative outcomes after THA.

Discussion:
Race, insurance provider, and zip code income quartile are associated with differences in the distance traveled to undergo THA. These findings may be indicative of underlying disparities in access to care across patient populations.
Incidence and Risk Factors for Patient-related Short-term Cancellation of Elective Arthroscopic Surgery: A Case-matched Study
Authors: Gruson Konrad I. , Lo Yungtai , Volaski Harrison , Sharfman Zachary , Shah Priyam 
Published: April 2022

Introduction:
Short-term cancellation of elective ambulatory orthopaedic surgery can result in disruption to the process flow of the operating room, with resultant negative financial implications for the health system. The risk factors for patient-related short-term cancellations within 24 hours of the surgical date have not been well defined.

Methods:
A retrospective review of a single orthopaedic surgery electronic internal database was done to identify all cancellations from January 1, 2016, through December 31, 2019, which were made within 24 hours of the surgical date. Inclusion criteria included elective arthroscopic procedures canceled solely for patient-related issues. Any cancellation for surgeon-related or ambulatory center–related reasons was excluded. Demographic patient and surgical data, including insurance type, employment status, previous history of cancellation for the same surgery, socioeconomic status based on the Area Deprivation Index, and surgery type, were tabulated. Each cancellation was matched 1:2 with noncanceled cases based on the anatomic site of the arthroscopy scheduled. Multivariable logistic regression was used to examine associations of patient demographic and medical characteristics with surgical cancellation.

Results:
There were 4,715 total arthroscopic procedures done during the study period, of which 126 (2.7%) were canceled within 24 hours of the surgery date. The mean age of the canceled cases was 44.9 ± 16.1 years (range, 14 to 77 years), with 46 females (43%) included. The presence of MRI of the involved joint within 6 months of surgery (adjusted odds ratio [aOR], 0.39, 95% confidence interval [CI], 0.17 to 0.91) and current employment (aOR, 0.56, 95% CI, 0.33-0.94) were independently predictive of noncancellation. Current smokers were more likely to cancel within 24 hours of surgery (aOR, 2.63, 95% CI, 1.4-4.9). Finally, having previously canceled the same surgery was significantly associated with a current surgical cancellation (P = 0.004).

Discussion:
Identification of the factors associated with short-term patient-related cancellation of elective arthroscopy may serve as the basis for preoperative interventions aimed specifically at those more likely to cancel. In turn, these interventions can minimize preventable cancellations.
Osteoarthritic Severity in Unresurfaced Patellae Does Not Adversely Affect Patient-reported Outcomes in Contemporary Primary TKA
Authors: Schmidt Gregory J. , Farooq Hassan , Deckard Evan R. , Meneghini R. Michael 
Published: April 2022

Introduction:
The degree of osteoarthritis (OA) acceptable to leave in a native patella during unresurfaced total knee arthroplasty (TKA) remains unknown. This study's purpose was to examine the effect of patellofemoral OA severity on patient-reported outcome measures (PROMs) in primary TKAs performed without patellar resurfacing.

Methods:
One hundred ninety-three primary TKAs performed without patellar resurfacing were retrospectively reviewed. Preoperative patellofemoral OA severity was graded on severity, marginal osteophytes, joint space narrowing, and chondral damage using accepted grading systems. Patellar tilt and tibiofemoral alignment were measured radiographically. PROMs were evaluated at a minimum of 1-year follow-up.

Results:
In multivariate regression, preoperative lateral patella Kellgren-Lawrence grade ≥2 was associated with superior change in Knee Society Score pain with level walking, higher absolute change in Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (P ≤ 0.029), and knees ‟always feeling normal” (odds ratio [OR] 3.12; P = 0.005). Osteoarthritis Research Society International atlas grades and Outerbridge classification scores did not significantly influence PROMs.

Discussion:
Worse preoperative OA severity in the lateral patellar facet, graded with the Kellgren-Lawrence system, predicted superior knee-specific PROMs in patients with unresurfaced patellae after contemporary TKA. This observation supports the clinical finding that patients with more severe OA have optimized patient outcomes and highlights the minimal contribution of patella OA to knee function after primary TKA.
Detección De Los Genes De Virulencia De Cepas De Helicobacter Pylori En Biopsias De Pacientes Guatemaltecos Con Cancer Gastrico
Authors: Hemández R.D. , Torres O.R. 
Published: April 2022

Helicobacter pylori ( H. pylori), es un bacilo de apariencia curva o espiral. Gram negativo, que habita la mucosa gástrica no productora de ácido en el ser humano; es responsable del 80 por ciento de los casos de gastritis y se asocia con otras patologías como lo son: úlceras, cáncer gástnco y lmfoma gástrico de tipo maltoma (linfoma de tejido linfoide asociado a mucosas) y afecta al 50 por ciento de la población mundial. La infección es comúnmente adquirida durante los primeros 10 años de vida, y persiste durante toda la v ida del paciente en la mayoría de los casos. Los principales factores de riesgo para la adquisición de la infección son condición socioeconórnica baja (especialmente durante la niñez). hábitos higiénicos deficientes, hacinamiento; además, algunos autores reportan una relación inversa en cuanto al nivel educativo y la infección por el microorganismo.
Considerando que tanto la infección por H. pylori como el cáncer gástrico son afecciones comunes entre la población guatemalteca, en el presente estudio se realizó una investigación acerca de la relación existente entre los casos de cáncer gástrico de un grupo de pacientes guatemaltecos y la infección por H. py­lori, estableciéndose, además, el patrón genético de las cepas de H. pylori asociadas a los casos de cáncer gástrico estudiados.
A Practitioner’s Guide to Intergovernmental Fiscal Transfers
Authors: Shah Anwar 
Published: April 2022

Intergovernmental fiscal transfers are a dominant feature of sub-national finance in most countries. They are used to ensure that revenues roughly match the expenditure needs of various orders (levels) of sub-national governments. They are also used to advance national, regional and local area objectives such as fairness and equity and creating a common economic union. The structure of these transfers create incentives for national, regional and local governments that have a bearing on fiscal management, macroeconomic stability, distributional equity, allocative efficiency and public services delivery. This paper reviews conceptual, empirical and the practice literature to distill lessons of policy interest in designing the fiscal transfers to create the right incentives for prudent fiscal managment and competitive and innovative service delivery. The paper provides practical guidance on the design of performance-oriented transfers that emphasize bottom-up, client- focused and results-based government accountability. It cites examples of simple but innovative grant designs that can satisfy grantors’ objectives while preserving local autonomy and creating an enabling environment for responsive, responsible, equitable and accountable public governance. The paper further provides guidance on the design and the practice of equalization transfers for regional fiscal equity as well as the institutional arrangements for implementation of such transfer mechanisms. The paper concludes with negative (practices to avoid) and positive (practices to emulate) lessons from international practices.
Agricultural Reforms in India
Authors: Dev Mahendra 
Published: April 2022

Issue: Jan-Feb 2021
This paper explores the recent farm laws passed by parliament and their impact on farmers’ income. The laws collectively offer greater freedom to cultivators to sell their produce at better prices and allow farmers to enter into contracts with processors, aggregators, wholesalers, large retailers and exporters at mutually agreed crop prices. The laws also encourage private investment into storage and warehousing by removing stockholding limits. To make these reforms work, some conditions may have to be fulfilled and imperfections and concerns have to be addressed, which are elaborated in the paper. Finally, the paper focuses on other agricultural reforms to improve the supply-side factors, such as rationalization of subsidies, land reforms, use of technology, strengthening institutions and governance, and improving rural infrastructure.
Grants from Centre and States’ Fiscal Marksmanship
Authors: Srinivasan Sharmadha , Misra Prakhar 
Published: April 2022

Issue: Jan-Feb 2021
In this paper, we aim to establish the issues with fiscal marksmanship of states’ revenue budgets. We particularly focus on the grants received from the Union government. Within grants, we find state plan schemes and centrally sponsored schemes to be the most volatile. Our analysis looks at three key stakeholders in the budget-making process and their role in poor fiscal marksmanship. These are the Centre, the states and the Finance Commission. The actuals could miss budget estimates due to the Centre misprojecting its revenues or expenditures, the states misprojecting their revenues, or the Finance Commission making errors while recommending grants. Poor estimation methods, weak capacity in drawing up budgets and implementing projects, specific conditionalities imposed either by the Centre or the Finance Commission and exogenous and random shocks that cannot be controlled for — all affect marksmanship of the states’ revenue budgets.
India’s Free Trade Agreements
Authors: Krishna Pravin 
Published: April 2022

Issue: Mar-Apr 2021
This paper reviews India’s experience with the free trade agreements (FTAs) that it signed over the last two decades. The trade outcomes under the agreements are found to be quite modest: The trade shares of India’s FTA partners stayed nearly constant over the past decade, and trade deficits with FTA partners, as a share of the overall deficit, did not increase over time. These findings challenge the assertion that India’s trade agreements have led to a widening of trade deficits and that they were responsible for the stagnation of the Indian manufacturing sector.
Etnobotani Hanjuang di Desa Sabuhur Kabupaten Tanah Laut Sebagai Buku Ilmiah Populer
Authors: Najmah Laily , Dharmono Dharmono , Riefani Maulana Khalid 
Published: April 2022

Etnobotani merupakan ilmu tentang mempelajari pemanfaatan suatu tumbuhan oleh masyarakat, adat, atau suku bangsa tertentu. Potensi local sekitar lingkungan dapat dijadikan sumber belajar, khususnya tumbuhan dalam lingkup etnobotani. Hanjuang memiliki penyebaran dan manfaat di Desa Sabuhur. Penelitian ini bertujuan untuk mengkaji etnobotani Hanjuang di Desa Sabuhur, mengetahui validitas, serta kepraktisan isi buku yang dikembangkan sebagai Buku Ilmiah Populer. Metode pada penlitian dengan pendekatan deskriptif untuk mendeskripsikan kajian etno-botani Hanjuang dengan melakukan wawancara menggunakan teknik snowball sampling dan penelitian pengembangan menggunakan evaluasi formatif Tessmer melalui tahapan self evaluation, expert review dan one to one. Hasil penelitian menunjukkan 6 kajian etnobotani yaitu Hanjuang merupakan tumbuhan perdu (botani) yang digunakan masyarakat Desa Sabuhur sebagai obat hipertensi (farmakologi), serta sebagai tanaman hias yang ditanam di pekarangan rumah (ekologi). Hanjuang digunakan sebagai bahan untuk upacara adat mandi-mandi pengantin (sosioantropologi), dan bisa dijual sebagai tanaman hias (ekonomi). Penamaan hanjuang sebagai ‘pawang’ dipercaya dapat menangkal makhluk halus (linguistik). Hasil pengembangan Buku Ilmiah Populer pada expert review dari dua validator memiliki Validitas Sangat Valid dengan persentase 94,7% dan hasil kepraktisan isi dari tiga orang mahasiswi Pendidikan Biologi FKIP ULM Banjarmasin yang telah menempuh mata kuliah Etnobotani dan lulus dengan nilai A mendapatkan persentase 93,0% dengan kriteria Sangat Baik.
Peningkatan Kinerja Guru Melalui Supervisi Edukatif Kolaboratif Secara Periodik Di SMAN 3 Kota Bima Tahun Pelajaran 2020/2021
Authors: Syaiful Syaiful 
Published: April 2022

Penelitian ini bertujuan untuk mengetahui peningkatan kinerja guru melalui supervisi edukatif kolaboratif secara periodik di SMAN 3 Kota Bima Tahun Pelajaran 2020/2021. Jenis penelitian adalah Penelitian Tindakan Sekolah (PTS), yang dirancang dalam dua siklus, tiap siklus terdiri dari empat tahapan, yaitu: perencanaan, pelaksanaan, pengamatan, dan refleksi. Subyek dalam penelitian ini adalah guru SMA Negeri 3 Kota Bima sebanyak 20 orang. Instrument yang digunakan adalah Lembar Observasi dan Lembar Evaluasi kegiatan. Analisis data menggunakan analisis deskriptif dan disajikan dalam persentase. Berdasarkan analisis data, yang telah dilakukan maka dapat disimpulkan bahwa terjadi peningkatan kinerja guru dari 73,89% pada siklus I menjadi 97,22% pada siklus II melalui supervisi edukatif kolaboratif secara periodik di SMAN 3 Kota Bima Tahun Pelajaran 2020/2021
Validitas Dan Keterbacaan Buku Saku Elektronik Di SMA Tentang Pteridophyta Di Bantaran Sungai Irigasi Rawa Desa Tanipah Kecamatan Mandastana
Authors: Yusuf Novita Anggriani , Hardiansyah Hardiansyah , Noorhidayati Noorhidayati 
Published: April 2022

Ditemukannya berbagai jenis Pteridophyta di kawasan Bantaran Sungai Irigasi Rawa Desa Tanipah Kecamatan Mandastana dapat dijadikan sebagai bahan pengayaan berbasis potensi lokal pada materi konsep plantae sub konsep Pteridophyta di SMA. Penelitian ini bertujuan untuk mendeskripsikan keanekaragaman Pteridophyta di Bantaran Sungai Irigasi Desa Tanipah Kecamatan Mandastana. Pengumpulan data diperoleh dengan teknik jelajah total pada bagian kiri dan kanan Bantaran Sungai Irigasi Rawa Desa Tanipah. Hasil identifikasi yang didukung oleh literatur kemudian dibuat menjadi sebuah buku saku elektronik. Pengembangan buku saku elektronik berbasis Flip HTML 5 menggunakan model Borg and Gall (1989). Buku saku elektronik dilakukan uji validasi dengan 3 validator ahli. Uji keterbacaan dilakukan oleh 9 orang peserta didik SMAN 1 Mandastana. Hasil Penelitian ditemukan ada 5 Familia yang terdiri dari 6 spesies Pteridophyta yaitu : Stenochlaena palustris, Lygodium microphyllum (Cav.) R. Br. Nephrolepis hirsutula, Pityrogamma calomelanos, Pteris vitatta L, dan Salvinia molesta. Uji validasi buku saku elektronik diperoleh nilai sebesar 87,46% dengan kriteria (Sangat Valid). UJi keterbacaan oleh peserta didik diperoleh nilai sebesar 89,62% dengan kriteria (Sangat Baik).
Therapeutic Properties of Trichinella spiralis (Nematoda) in Chronic Degenerative Diseases
Authors: Nevárez-Lechuga Christian-Irene , Meza-Lucas Antonio , Escobar-Gutiérrez Alejandro , Wong-Baeza Carlos , Baeza Isabel , de-la-Rosa-Arana Jorge-Luis 
Published: April 2022

Diseases produced by helminth parasites occur frequently in underdeveloped countries where they present a serious public health problem. At the same time, in these regions, a lower rate of autoimmune and allergic diseases has been observed. Due to these observations, some researchers have proposed that some helminths, such as Trichinella spiralis or its proteins, have strong anti-inflammatory potential, or have assessed them as modulating agents of the immune response. T. spiralis shifts the host immune response from a Th1 profile, characterized by pro-inflammatory cytokines, to a Th2 profile, characterized by the release of different cytokines with anti-inflammatory properties. This parasite has shown high therapeutic potential in a wide variety of disease models. In one of the most promising, the experimental lupus model in mice, the release of anti-inflammatory cytokines IL-4 and IL-10 and delayed onset of the key clinical features of the experimental lupus model for at least 5 months were observed, when previously parasitized. This is the first study to date that focuses on the use of T. spiralis as an immunomodulator in lupus disease. In conclusion, further study of the immune response generated by the parasite is necessary to advance the development of new therapies for inflammatory diseases.
“Salamandra”: Filosofia-Performance, corpo e saúde holística
Authors: Vieira Alba Pedreira 
Published: April 2022

A partir da Prática Artística como Pesquisa e da Filosofia-Performance, problematizo como o corpo performático constrói, reconstrói e cambia sentidos de fenômenos diversos, ampliando entendimentos do movimento e do gesto como exercício filosófico e aliados a dimensões de saúde holística. Compartilho trabalhos em que seres se movem enquanto geram autoconhecimento, potência energética e espiritualizada relacionadas à qualidade de vida. A Performance “Salamandra” (2018) e o projeto de intercâmbio artístico “Salamandra” (2020), foram realizados em momentos de doenças, dores e aflições. Reflexões complexificam conexões teórico-práticas e alargam pensamentos sobre cura, ciência, realidade, corpo, filosofia, performance, cognição, imaginação e arte.
Asthma Control Level and Relating Socio-Demographic Factors in Hospital Admissions
Authors: Yalçınkaya Gönül , Kılıç Mahmut 
Published: April 2022

Purpose: Asthma is one of the serious public health problems that we face today and the rate of complete control is very low. This study aims to determine the level of asthma control and its relationship with socio-demographic factors in asthma patients.
Methods: This cross-sectional study was conducted between November 2020-April 2021 among people aged 18-64 who applied to the hospital and were not diagnosed with asthma. The data of the research were made with the personal information form, ACT (asthma control test). ACT is a questionnaire consisting of 5 questions. Patients rate each question between one and five points. The total score of the five questions forms the test result. If the total score is 25, it is considered as full control, 24-20 as partial control, and ≤19 as not under control. In the research, 206 people participated.
Results: Of the participants, 60.7% were female, 60.2% had a family history of asthma, 94.2% of them used asthma medication, and the average age was 45.7±13.85. In the last 12 years, 50.5% of asthma patients stated that they applied to the emergency department due to respiratory problems, and 23.3% were hospitalized due to these problems. It was determined that 78.6% of asthma patients were not under control, 21.4% were under partial control, and there was no patient under full control. The mean age (48.8) and body mass index (BMI) (29.4) of those whose asthma was not under control were higher than those with partial control (32.2 and 24.7, respectively) (p<0.001). It has been determined that the probability of asthma not being controlled increases as age and BMI increase, and life satisfaction decreases, and it is higher in quit smokers than in current smokers (p<0.05).
Conclusion: Asthma is largely uncontrolled. The rate of uncontrolled asthma increases with increasing age and BMI. Patients with high BMI should be supported to lose weight and should be directed to exercise.
The regulation of hsacirc_004413 promotes proliferation and drug resistance of gastric cancer cells by acting as a competing endogenous RNA for miR-145-5p
Authors: Zhou Fusheng , Ding Weiqun , Mao Qiqi , Jiang Xiaoyun , Chen Jiajie , Zhao Xianguang , Xu Weijia , Huang Jiaxin , Zhong Liang , Sun Xu 
Published: April 2022

Background
Whether circRAN, which acts as a microRNA sponge, plays a role in 5-fluorouracil (5-Fu) resistant gastric cancer has not been reported. In this study, a 5-Fu resistant cell line with an IC50 of 16.59 µM was constructed.

Methods
Using comparative analysis of circRNA in the transcriptomics of resistant and sensitive strains, 31 differentially expressed circRNAs were detected, and the microRNA interacting with them was predicted.

Results
Hsacirc_004413 was selected for verification in drug resistant and sensitive cells. By interfering with hsacirc_004413 using antisense RNA, the sensitivity of drug resistant cells to 5-Fu was significantly promoted, and the apoptosis and necrosis of the cells were significantly increased. In sensitive cells, inhibition by inhibitors enhanced the resistance of cells to 5-Fu. We hypothesize that hsacirc_004413 makes gastric cancer cells resistant to 5-Fu mainly through adsorption of miR-145-5p.
Putting small and big pieces together: a genome assembly approach reveals the largest Lamiid plastome in a woody vine
Authors: Fonseca Luiz Henrique M. , Nazareno Alison G. , Thode Verônica A. , Zuntini Alexandre R. , Lohmann Lúcia G. 
Published: April 2022

The plastid genome of flowering plants generally shows conserved structural organization, gene arrangement, and gene content. While structural reorganizations are uncommon, examples have been documented in the literature during the past years. Here we assembled the entire plastome of Bignonia magnifica and compared its structure and gene content with nine other Lamiid plastomes. The plastome of B. magnifica is composed of 183,052 bp and follows the canonical quadripartite structure, synteny, and gene composition of other angiosperms. Exceptionally large inverted repeat (IR) regions are responsible for the uncommon length of the genome. At least four events of IR expansion were observed among the seven Bignoniaceae species compared, suggesting multiple expansions of the IRs over the SC regions in the family. A comparison with 6,231 other complete plastomes of flowering plants available on GenBank revealed that the plastome of B. magnifica is the longest Lamiid plastome described to date. The newly generated plastid genome was used as a source of selected genes. These genes were combined with orthologous regions sampled from other species of Bignoniaceae and all gene alignments concatenated to infer a phylogeny of the family. The tree recovered is consistent with known relationships within the Bignoniaceae.