bluuebunny/crossref_metadata_2025_split huggingface dataset:
GAMBARAN PENERAPAN DISIPLIN PROTOKOL KESEHATAN SELAMA PANDEMI COVID-19 DI SD NEGERI CIKURAY DESA CIBEBER I KECAMATAN LEUWILIANG KABUPATEN BOGOR TAHUN 2021
Authors: Novianti Djunaedi Jihan , Listyandini Rahma , Asnifatima Andi 
Published: February 2022

Banyak ditemukan kasus Covid-19 pada pekerja termasuk juga pada guru. Saat ini sekolah banyak yang telah dibuka maka dari itu penerapan protokol kesehatan di sekolah harus diperhatikan dan perilaku yang baik terhadap protokol kesehatan selalu dijaga. Tujuan dari penelitian ini yaitu mengetahui gambaran perilaku tenaga kerja dan penerapan program disiplin protokol kesehatan selama pandemi Covid-19 di SD Negeri Cikuray Desa Cibeber I Kecamatan Leuwiliang Kabupaten Bogor Tahun 2021. Penelitian ini menggunakan metode kualitatif dengan informan penelitian terdiri dari 4 informan yang dipilih berdasarkan kesesuaian dan kecukupan data. Informan kunci terdiri dari satu orang yaitu kepala sekolah, kemudian untuk informan inti ada 3 orang yaitu 2 orang guru dan satu orang petugas kebersihan. Variabel yang terdapat dalam penelitian ini yaitu pengetahuan, sikap, fasilitas sanitasi dan higiene, ketersediaan APD, kebijakan protokol kesehatan, dan penerapan protokol kesehatan di Sekolah. Hasil yang didapat yaitu sebagian besar memiliki pengetahuan yang baik dan juga memiliki sikap positif, ketersediaan fasilitas sanitasi dan higiene sudah memadai, namun untuk APD yaitu masker belum tersedia, kemudian tidak adanya kebijakan tertulis mempengaruhi penerapan protokol kesehatan sehingga penerapan protokol kesehatan berdasarkan kebijakan di satuan pendidikan sudah cukup namun belum dapat dikatakan sangat baik namun perilaku penerapan protokol kesehatan tenaga kerja sudah baik.
KEPATUHAN ANAK-ANAK TERHADAP PROTOKOL KESEHATAN COVID-19 SAAT PERGI BELAJAR MENGAJI DI RT.003 PERUMAHAN SARANA INDAH RESIDENCE 2020
Authors: Rahmah Syifaur , Saputra Nasution Ade 
Published: February 2022

Latar Belakang : Pandemi Novel Coronavirus Disease 2019 (COVID-19) yang disebabkan oleh virus SARS CoV-2 ini berawal dari Wuhan, China, menyebar ke lebih dari 200 negara dan mengakibatkan puluhan ribu kematian termasuk anak-anak. Tanda dan gejala umum infeksi COVID-19 antara lain gejala gangguan pernapasan akut seperti demam, batuk dan sesak napas. Masa inkubasi rata-rata 5-6 hari dengan masa inkubasi terpanjang 14 hari. Pada kasus COVID-19 yang berat dapat menyebabkan pneumonia, sindrom pernapasan akut, gagal ginjal, dan bahkan kematian. Tujuan penyuluhan pengabdian ini adalah untuk mengetahui kepatuhan anak- anak terhadap protokol kesehatan Covid-19 saat pergi belajar mengaji di Rt.003 Perumahan Sarana Indah Residence. Metode : Penelitian ini menggunakan analisis deskriptif dengan pendekatan kuantitatif, Pengisian Pre-Test dan Post-Test melalui Google Formulir. Kuesioner dibagikan melalui pesan pribadi Whatsapp. Sampel dalam penelitian ini berjumlah 34 orang, metode pengambilan sampel menggunakan total sampling. Program penyuluhan dilakukan secara lisan tentang etika batuk dan bersin, mencuci tangan yang baik dan benar dengan mengikuti 6 langkah, dan tentang protokol kesehatan seperti memakai masker, jaga jarak 1-2 meter, mencuci tangan pake sabun di air mengalir. Hasil : Setelah dilakukan penyuluhan dan edukasi didapatkan hasil bahwa pengetahuan, perilaku, dan sikap responden mengalami peningkatan yang cukup baik yaitu dengan presentase 70-95% (24-31 orang) dari jumlah responden sebanyak 34 orang.
GESTÃO ESCOLAR – CONFIGURAÇÃO DO ESTATUTO EPISTEMOLÓGICO
Authors: Dos Santos Adelcio Machado , Rietter Gustavo , Baade Joel Haroldo 
Published: February 2022

A Gestão Escolar pode ser conceituada nos termos de política diretora consistente em complexo sistema de processos criadores de condições propícias às atividades dos grupos que operam em divisão do trabalho. Ela segue prioridades estabelecidas para a educação, as quais resultam de uma reflexão sistemática e contextual, acerca dos problemas educacionais da realidade. Com as modificações introduzidas na escola e no seu entorno, em decorrência do processo de globalização econômica e do desenvolvimento de tecnologias, a Gestão Escolar demanda habilitação para adversar estes reptos. Não se trata de atividade puramente técnica e científica, divorciada dos valores e objetivos educacionais; é uma atividade que pode facilitar e estruturar a definição de objetivos. Outrossim, pode concretizar expressão operacional. Destarte, a definição do estatuto epistemológico da Gestão Escolar constitui em necessidade impostergável, uma vez que pode contribuir para a melhoria educacional. Em suma, Gestão Escolar, antes de qualquer ontologia, constitui-se em atividade pedagógica.
Palavras-Chave: Gestão. Apoio ao magistério. Educação Básica.

Abstract: School Management can be conceptualized in terms of a directive policy consisting of a complex system of processes that create conditions conducive to the activities of groups that operate in a division of labor. It follows established priorities for education, which result from a systematic and contextual reflection on the educational problems of reality. With the changes introduced in the school and in its surroundings, as a result of the process of economic globalization and the development of technologies, School Management demands qualification to face these challenges. It is not a purely technical and scientific activity, divorced from educational values and objectives; it is an activity that can facilitate and structure the definition of objectives. Furthermore, it can concretize operational expression. Thus, the definition of the epistemological status of School Management constitutes an urgent need, since it can contribute to educational improvement. In short, School Management, before any ontology, is a pedagogical activity.
Keywords: Management. Support for the teaching profession. Basic Education.
Harapan Stakeholder Tentang Kompetensi Lulusan Program Studi Pendidikan Nonformal Universitas Bengkulu
Authors: Kristanti Endah , Zulkarnain Rufran , Sofino Sofino 
Published: February 2022

Tujuan dari penelitian ini untuk mengetahui harapan stakeholder tentang kompetensi lulusan Program Studi Pendidikan Nonformal Fakultas Keguruan Dan Ilmu Pendidikan Universitas Bengkulu. Penelitian ini merupakan penelitian kualitatif. Hasil penelitian menunjukkan, (1) Harapan stakeholder pada kompetensi aspek sikap adalah taat agama, cepat tanggap membantu teman sejawatnya, antusias pada saat hari besar nasional, , tanggap dalam memahami lingkungan sosialnya, disiplin, bertanggungjawab, memiliki keberanian. (2) Harapam stakeholder pada kompetensi aspek pengetahuan adalah mencari informasi perkembangan pendidikan nonformal, dapat mengetahui metode yang tepat bagi orang dewasa, mampu menyusun rancangan kegiatan pembelajaran, dapat memberikan ide yang terbaru terhadap pendidikan. (3) Harapan stakeholder pada kompetensi keterampilan umum adalah menunjukkan kinerja yang baik, dapat memberikan ide sesuai permasalahan, dapat mengaplikasikan teknologi baru, dapat menjalin kerjasama yang baik dapat merancang tata kelola lembaga pendidikan. (4) Harapan stakeholder pada kompetensi aspek keterampilan khusus adalah, mengembangkan program di lembaga PNF, mampu mengembangkan rancangan pengelolaan lembaga PNF, dapat mengembangkan potensi masyarakat.
Pembinaan Anak Jalanan oleh Rumah Singgah Al-Ma’un
Authors: Sagita Yola Septri , Zulkarnain Rufran , Sofino Sofino 
Published: February 2022

Tujuan penelitian ini untuk mengetahui dan mendeskripsikan secara rinci mengenai profil seorang anak jalanan yang menjalani kegiatan belajar atau proses Pembinaan dengan pemberdayaan bernama Nurul Aulia yang dilakukan di Rumah Singgah Al-Ma’un Kota Bengkulu. Penelitian ini merupakan jenis penelitian deksriptif-kualitatif. Penelitian ini dilakukan dengan mengunakan teknik pengumpulan data yaitu teknik wawancara, observasi dan dokumentasi. Pada proses pemeriksaan keabsahan data adalah dengan menggunakan trianggulasi berupa trianggulasi waktu, trianggulasi subjek, dan trianggulasi teknik. Manfaat yang didapatkan di Rumah Singgah Al-Ma’un yaitu manfaat Kognitif dan afektif. Hasil penelitian ini menyatakan bahwa Rumah Singgah Al-Ma’un sebagai lembaga pendidikan nonformal memang benar adanya sebagai salah satu lembaga yang melaksanakan pemberdayaan masyarakat salah satunya adalah kepada anak jalanan yang bernama Nurul Aulia.
Relação entre uso do esquema antirretroviral e aterosclerose coronariana em pacientes HIV positivos no estado de Sergipe
Authors: Oliveira Débora Kelly Santos de , Aguiar João Eduardo Andrade Tavares de , Rodrigues Alexia Ferreira , Carvalho Vinícius Fernando Alves , Oliveira Joselina Luzia Menezes , Sousa Antônio Carlos Sobral , Correia Dalmo , Silva Ângela Maria da 
Published: February 2022

A terapia antirretroviral (TARV) coincide com a evidencia da ocorrência de doenças crônicas cardiovasculares de origem aterosclerótica, quando associada a uma terapia de longo prazo. O objetivo foi avaliar a relação entre aterosclerose e uso de esquema antirretroviral no tratamento de pacientes HIV positivo, e quantificar o escore de cálcio neste grupo, correlacionando-o com o tempo de uso da TARV. Trata-se de um estudo tranversal de pacientes adultos portadores de HIV/AIDS, selecionados de forma consecutiva e não-aleatória, assintomáticos do ponto de vista cardiovascular, provenientes dos dois serviços de referência em atendimento ambulatorial do estado de Sergipe, com idade maior que 18 anos e em uso de TARV. Da amostra, 65,4% eram do sexo masculino e 34,6% do sexo feminino, com idade média de 46 anos. A aterosclerose coronariana, detectada pelo escore de cálcio, foi encontrado em 24 pacientes (31,17%). A duração da terapia antirretroviral se relacionou à aterosclerose e houve diferenças significativas entre os diferentes esquemas antirretrovirais. Além disso, os resultados mostram uma associação entre TARV contendo IP. A idade e o tempo de exposição ao uso da TARV foram significativos na presença de aterosclerose. Os valores de p foram considerados estatisticamente significativos em 100% das variáveis analisadas e o desafio é promover a prevenção de riscos cardiovasculares para reduzir o número de eventos coronarianos, e o perfil traçado com esta coleta permitirá uma abordagem mais criteriosa desses pacientes, sobretudo no caráter preventivo com o cuidado dos pacientes portadores de HIV/AIDS no estado de Sergipe.
Positivization of Sharia Regional Regulations in North Sumatra
Authors: Irwansyah Irwansyah , Ananda Faisar , Zulham Zulham 
Published: February 2022

The inability of the law to be an accommodating and acceptable rule makes for disharmony over diversity in Indonesia. Various sharia-nuanced regional regulations continue to emerge in various regional lines in Indonesia. However, it is necessary to conduct legal analysis related to its existence in the constitutional legal system in Indonesia. The research method used is normative juridical. The results showed that in a democratic country positivization of Islamic law both in absolute (law) and relatif (local regulations) does not violate in the constitutional legal system that also guarantees the fulfillment of human rights to its citizens. In addition, the lack of political will from the regional government of North Sumatra to support sharia-nuanced regional regulations proposed by districts / cities that are less responded to by the government at the provincial level that hinders the process of positivization of sharia-nuanced regional regulations in North Sumatra
Analysis of Breakthrough Reactions in 1,143 Desensitization Procedures in a Single Tertiary Hospital Using a One-Bag Desensitization Protocol
Authors: Kim Hyun Hwa , Seo Jeongmin , Ahn Yoon Hae , Kim Hyunjee , Yoon Jeong-Eun , Suh Jang Ho , Kang Dong Yoon , Lee Suh Young , Kang Hye-Ryun 
Published: February 2022

BackgroundDrug desensitization is helpful for patients who have experienced significant hypersensitivity reactions (HSRs) to antineoplastic agents. One-bag desensitization protocols, attracting attention in recent years, need to be validated on their safety and efficacy in a large number.MethodsOne-bag desensitization procedures conducted from 2018 to 2020 were analyzed; their outcomes and the risk factors for breakthrough reactions (BTRs) were assessed in desensitization procedures to major drug types (platins, taxanes, and monoclonal antibodies).ResultsA total of 1,143 procedures of one-bag desensitization were performed in 228 patients with 99% completion rate. BTRs occurred in 26% of the total desensitization procedures—34% in platins, 12% in taxanes, and 18% in mAbs. BTR occurrence rate decreased along the desensitization process with 80% of BTRs occurring within the 6th desensitization attempts. Severe BTR occurred more frequently with severe initial HSRs (1% in mild to moderate initial HSRs vs. 16% in severe). Severe initial HSR was also a significant risk factor for moderate to severe BTR in platins (odds ratio 1.56, 95% confidence interval [CI] 1.06–2.29, p = 0.025). The use of steroid was also associated with lower occurrence of moderate to severe BTR (odds ratio 0.50, 95% CI 0.35–0.72, p &lt; 0.001).ConclusionMost patients with HSRs to antineoplastic agents can safely receive chemotherapy through a one-bag desensitization protocol. Further studies on each drug with larger sample size can help verify the risk factors of BTRs and evaluate the efficacy of steroid premedication in improving the safety of desensitization in high-risk patients.
Very Early Corona Treatment-Mediated Artificial Incubation of Silkworm Eggs and Germline Transformation of Diapause Silkworm Strains
Authors: Zhang Yu-Li , Huang Yang , Wang Ping-Yang , Li Qiang , Bi Li-Hui , Zhao Ai-Chun , Xiang Zhong-Huai , Long Ding-Pei 
Published: February 2022

Diapause is an important biological characteristic for many insect species to adapt to adverse environmental conditions and maintain the continuity of the race. Compared with the traditional hydrochloric acid or/and cold storage treatment methods, the artificial corona incubation technology of silkworm (Bombyx mori) eggs has many advantages including, the absence of pollution, easy operation and safety. However, this technology has not yet been applied in sericulture. In this study, we developed a novel artificial corona instrument to successfully disrupt the diapause of newly laid and refrigerated eggs from various Chinese and Japanese lineage silkworm strains. Subsequently, we invented a very early corona treatment (VECT) strategy to prevent the diapause of newly laid silkworm eggs within 4 h of oviposition. The hatching rates of the larvae were more than 95% in all diapause silkworm strains, which was comparable to the effect of the traditional HCl treatment strategy. In addition, we developed a combination strategy of VECT and pre-blastoderm microinjection and successfully created transgenic silkworms in various diapause strains. The results of the current study can aid in improving the corona artificial incubation technology and promote its application in sericulture.
Comprehensive Analysis of the Glycolysis-Related Gene Prognostic Signature and Immune Infiltration in Endometrial Cancer
Authors: Yang Xiao , Li Xingchen , Cheng Yuan , Zhou Jingyi , Shen Boqiang , Zhao Lijun , Wang Jianliu 
Published: February 2022

Glucose metabolic reprogramming and immune imbalance play important roles in the progression of cancers. The purpose of this study is to develop a glycolysis-related prognostic signature for endometrial cancer (EC) and analyze its relationship with immune function. The mRNA expression profiling of the glycolysis-related genes and clinical data of EC patients were downloaded from The Cancer Genome Atlas (TCGA). We identified a glycolysis-related gene prognostic signature for predicting the prognosis of EC by using The Least Absolute Shrinkage and Selection Operator (LASSO) regression and found the patients in the high-risk group had worse survival prognosis. Multivariate Cox regression analysis showed that the gene signature was an independent prognostic factor for EC. The ROC curve confirmed the accuracy of the prognostic signature (AUC = 0.730). Then, we constructed a nomogram to predict the 1–5 years survival rate of EC patients. The association between the gene signature and immune function was analyzed based on the “ESTIMATE” and “CIBERSORT” algorithm, which showed the immune and ESTIMATE scores of patients in the high-risk group were lower, while the low immune and ESTIMATE scores were associated with a worse prognosis of patients. The imbalance of immune cells was also found in the high-risk group. Further, the protein of CDK1, a gene in the signature, was found to be closely related to prognosis of EC and inhibition of CDK1 could inhibit migration and promote apoptosis of EC cells. This study reveals a link between glycolysis-related gene signature and immunity, and provides personalized therapeutic targets for EC.
Multi-Omics Prognostic Signatures Based on Lipid Metabolism for Colorectal Cancer
Authors: Sun YuanLin , Liu Bin , Chen YuJia , Xing YanPeng , Zhang Yang 
Published: February 2022

Background: The potential biological processes and laws of the biological components in malignant tumors can be understood more systematically and comprehensively through multi-omics analysis. This study elaborately explored the role of lipid metabolism in the prognosis of colorectal cancer (CRC) from the metabonomics and transcriptomics.Methods: We performed K-means unsupervised clustering algorithm and t test to identify the differential lipid metabolites determined by liquid chromatography tandem mass spectrometry (LC-MS/MS) in the serum of 236 CRC patients of the First Hospital of Jilin University (JLUFH). Cox regression analysis was used to identify prognosis-associated lipid metabolites and to construct multi-lipid-metabolite prognostic signature. The composite nomogram composed of independent prognostic factors was utilized to individually predict the outcome of CRC patients. Glycerophospholipid metabolism was the most significant enrichment pathway for lipid metabolites in CRC, whose related hub genes (GMRHGs) were distinguished by gene set variation analysis (GSVA) and weighted gene co-expression network analysis (WGCNA). Cox regression and least absolute shrinkage and selection operator (LASSO) regression analysis were utilized to develop the prognostic signature.Results: Six-lipid-metabolite and five-GMRHG prognostic signatures were developed, indicating favorable survival stratification effects on CRC patients. Using the independent prognostic factors as variables, we established a composite nomogram to individually evaluate the prognosis of CRC patients. The AUCs of one-, three-, and five-year ROC curves were 0.815, 0.815, and 0.805, respectively, showing auspicious prognostic accuracy. Furthermore, we explored the potential relationship between tumor microenvironment (TME) and immune infiltration. Moreover, the mutational frequency of TP53 in the high-risk group was significantly higher than that in the low-risk group (p &lt; 0.001), while in the coordinate mutational status of TP53, the overall survival of CRC patients in the high-risk group was significantly lower than that in low-risk group with statistical differences.Conclusion: We identified the significance of lipid metabolism for the prognosis of CRC from the aspects of metabonomics and transcriptomics, which can provide a novel perspective for promoting individualized treatment and revealing the potential molecular biological characteristics of CRC. The composite nomogram including a six-lipid-metabolite prognostic signature is a promising predictor of the prognosis of CRC patients.
Human Decidual Mesenchymal Stem Cells Obtained From Early Pregnancy Improve Cardiac Revascularization Postinfarction by Activating Ornithine Metabolism
Authors: Chen Kegong , Bai Long , Lu Jingtong , Chen Wei , Liu Chang , Guo Erliang , Qin Xionghai , Jiao Xuan , Huang Mingli , Tian Hai 
Published: February 2022

BackgroundCompared with bone marrow mesenchymal stem cells (BMSCs), decidual mesenchymal stem cells (DMSCs) are easy to obtain and exhibit excellent angiogenic effects, but their role in cell transplantation after myocardial infarction (MI) remains unclear.MethodsBMSCs and DMSCs were harvested from healthy donors. The effects of both cell types on angiogenesis were observed in vitro. Metabonomics analysis was performed to compare different metabolites and screen critical metabolic pathways. A murine model of acute myocardial infarction (AMI) was established, which was randomized into five groups (control, BMSC, DMSC, DMSC + ODCshRNA and BMSC + ODC consisting of 50 animals, equally divided into each group). The therapeutic effect of DMSCs on MI in rats was assessed based on neovascularization and cardiac remodeling.ResultsDMSCs exhibited a better angiogenic effect on human umbilical vein endothelial cells (HUVECs) than BMSCs in vitro. In addition, ornithine metabolism, which is associated with vascularization, was significantly increased in DMSCs. The transplantation of DMSCs in the rat MI model significantly enhanced angiogenesis of the infarct border area and improved cardiac remodeling and dysfunction postinfarction compared with BMSCs. Furthermore, inhibition of ornithine metabolism by silencing ornithine decarboxylase (ODC) in DMSCs partly abolished the benefits of DMSC transplantation.ConclusionCompared with BMSCs, DMSCs exhibited better efficacy in improving revascularization and heart remodeling post-MI via the activation of ODC-associated ornithine metabolism.
Point of Care Measurement of Body Mass Index and Thyroid Nodule Malignancy Risk Assessment
Authors: Ahmadi Sara , Pappa Theodora , Kang Alex S. , Coleman Alexandra K. , Landa Iñigo , Marqusee Ellen , Kim Matthew , Angell Trevor E. , Alexander Erik K. 
Published: February 2022

BackgroundLarge scale epidemiology studies have suggested obesity may increase the risk of thyroid cancer, though no prospective analyses using real-world measurement of BMI at a time proximate to initial thyroid nodule evaluation have been performed.MethodsWe performed a prospective, cohort analysis over 3 years of consecutive patients presenting for thyroid nodule evaluation. We measured BMI proximate to the time of initial evaluation and correlated this with the final diagnosis of benign or malignant disease. We further correlated patient BMI with aggressivity of thyroid cancer, if detected.ResultsAmong 1,259 consecutive patients with clinically relevant nodules, 199(15%) were malignant. BMI averaged 28.6 kg/m2 (SD: 6.35, range:16.46-59.26). There was no correlation between the measurement of BMI and risk of thyroid cancer (p=0.58) as mean BMI was 28.9 kg/m2 and 28.6 kg/m2 in cancerous and benign cohorts, respectively. Similarly, BMI did not predict aggressive thyroid cancer (p=0.15). While overall nodule size was associated with increased BMI (p&lt;0.01), these data require further validation as obesity may hinder nodule detection until large.ConclusionIn contrast to findings published from large scale association studies drawn from national databases, these prospective data of consecutive patients presenting for nodule evaluation detect no association of obesity (as measured by BMI) with thyroid cancer. Real time measurement of BMI at the time of thyroid nodule evaluation does not contribute to cancer risk assessment.