bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of standardized ileal digestible lysine level on growth performance and economic return for 18 to 128 kg Duroc-sired pigs
Authors: Royall Rafe Q , Goodband Robert D , Tokach Mike D , DeRouchey Joel M , Woodworth Jason C , Gebhardt Jordan T 
Published: August 2022

AbstractThe recent shift of the U.S. swine industry toward improved pork quality, such as color, marbling, and firmness, has led to increased use of Duroc-sired pigs in the marketplace. Our objective was to determine the standardized ileal digestible (SID) Lys requirement estimates for Duroc-sired (600 × 241, DNA, Columbus, NE) pigs from 18 to 128 kg BW. We conducted a series of experiments using corn–soybean meal-based diets with pigs allotted to 6 or 7 treatments in randomized complete block designs. In all experiments an equal number of barrows and gilts were used within a pen. In experiment 1, 300 pigs (initially 18.4 ± 0.50 kg) were used with 5 pigs per pen and 10 pens per treatment with 6 SID Lys levels from 1.00% to 1.50%. Increasing SID Lys increased (linear, P &lt; 0.040) final BW, ADG, G:F, and Lys intake/kg of gain, and decreased (linear, P = 0.012) ADFI. In experiment 2, 608 pigs (initially 36.3 ± 0.91 kg) were used with 7 to 9 pigs per pen and 12 pens per treatment with 6 SID Lys levels from 0.80% to 1.20%. Increasing SID Lys increased (linear, P ≤ 0.036) ADG, G:F, and Lys intake/kg of gain. In experiment 3, 700 pigs (initially 53.2 ± 0.86 kg) were used with 8 to 10 pigs per pen and 12 pens per treatment with 6 SID Lys levels from 0.65% to 1.00%. Increasing SID Lys increased (linear, P &lt; 0.001) final BW, ADG, and Lys intake/kg of gain, decreased (quadratic, P = 0.004) ADFI, and improved (quadratic, P &lt; 0.001) G:F. In experiment 4, 616 pigs (initially 76.4 ± 1.25 kg) were used with 8 to 10 pigs per pen and 5, 6, or 11 pens per treatment with 7 SID Lys levels from 0.58% to 1.00%. Increasing SID Lys increased (linear, P ≤ 0.022) ADG, Lys intake per kilogram of gain, and G:F. In experiment 5, 679 pigs (initially 103.8 ± 1.32 kg) were used with 8 to 10 pigs per pen and 11 or 12 pens per treatment with 6 SID Lys levels from 0.43% to 0.78%. Increasing SID Lys increased (linear, P ≤ 0.043) final BW, ADG, and Lys intake per kilogram of gain, and improved (quadratic, P ≤ 0.032) G:F. Using results from all experiments, the quadratic equation of Lys:calorie ratio, g of SID Lys/Mcal of NE = 0.0002611 × BW2 – 0.0711037 × BW + 7.284 was developed to reflect the requirement for maximal growth performance from 18 to 128 kg BW. Maximal income over feed cost (IOFC) is best described by the quadratic equation: Lys:calorie ratio, g of SID Lys/Mcal of NE = 0.0001558 × BW2 − 0.04030769 × BW + 5.410. These data provide updated SID Lys estimates for Duroc-sired grow-finish pigs.
Differential tolerance of the woody invasiveHakea sericeato drought and terminal heat stress
Authors: Morais Maria C , Ferreira Helena , Cabral João A , Gonçalves Berta 
Published: August 2022

AbstractDrought and extreme temperatures are likely to be more common and intense in the Mediterranean region as a consequence of climate change. Both stresses usually arise together in the field, but our understanding of their joint influence on the performance of invasive alien species (IAS) is limited. Thus, the main objective of the present study is to fill this gap by analyzing the individual and combined effects of drought and terminal heat stress on the leaf physiology, biochemistry and growth of Hakea sericea Schrader, one of the most problematic IAS in the Mediterranean-type ecosystems. In this study, 1-year-old plants of H. sericea were exposed to four treatments under controlled conditions: control (CT), drought (DS), terminal heat stress (Ht), and combined Ht and DS (DHt). The DS treatment alone caused a marked reduction in shoot biomass, net photosynthetic (A) rate and stomatal conductance, while increasing the proline content, as compared with CT plants. In turn, the Ht treatment promoted the accumulation of malondialdehyde but hastened the decline in all gas exchange parameters, and also decreased leaf photosynthetic pigments, carotenoids, proline and relative water contents Exposure of H. sericea plants to the combined DHt exacerbated the impacts of Ht, which was accompanied by significant decreases in net photosynthetic and transpiration rates, and intrinsic water-use efficiency. Principal component analysis clearly separated the DHt from the other treatments and revealed similarities between DS and CT treatment. These findings suggest that xerothermic weather conditions might modify the fitness, competitive ability, resilience and spread of this IAS, thereby providing opportunities for its control.
Inhibition of protein arginine methyltransferase 1 alleviates liver fibrosis by attenuating the activation of hepatic stellate cells in mice
Authors: Yan Fang‐Zhi , Qian Hui , Liu Fang , Ding Chen‐Hong , Liu Shu‐Qing , Xiao Meng‐Chao , Chen Shi‐Jie , Zhang Xin , Luo Cheng , Xie Wei‐Fen 
Published: August 2022

AbstractProtein arginine methyltransferase 1 (PRMT1) has been reported to be involved in various diseases. The expression of PRMT1 was increased in cirrhotic livers from human patients. However, the role of PRMT1 in hepatic fibrogenesis remains largely unexplored. In this study, we investigated the effect of PRMT1 on hepatic fibrogenesis and its underlying mechanism. We found that PRMT1 expression was significantly higher in fibrotic livers of the mice treated with thioacetamide (TAA) or 3,5‐diethoxycarbonyl‐1,4‐dihydrocollidine (DDC) diet. Immunofluorescence staining revealed that PRMT1 expression was augmented in both hepatocytes and hepatic stellate cells (HSCs) in the fibrotic livers. Applying a selective inhibitor of PRMT1, PT1001B, significantly suppressed PRMT1 activity and mitigated liver fibrosis in mice. Hepatocyte‐specific Prmt1 knockout did not affect liver fibrosis in mice. PRMT1 overexpression promoted the expression of fibrotic genes in the LX‐2 cells, whereas knockdown of PRMT1 or treatment with PT1001B exhibited reversal effects, suggesting that PRMT1 plays an important role in HSC activation. Additionally, HSC‐specific Prmt1 knockout attenuated HSC activation and liver fibrosis in TAA‐induced fibrotic model. RNA‐seq analysis revealed that Prmt1 knockout in HSCs significantly suppressed pro‐inflammatory NF‐κB and pro‐fibrotic TGF‐β signals, and also downregulated the expression of pro‐fibrotic mediators in mouse livers. Moreover, treatment with PT1001B consistently inhibited hepatic inflammatory response in fibrotic model. In conclusion, PRMT1 plays a vital role in HSC activation. Inhibition of PRMT1 mitigates hepatic fibrosis by attenuating HSC activation in mice. Therefore, targeting PRMT1 could be a feasible therapeutic strategy for liver fibrosis.
The Experiences of People Who Are Incarcerated in Accessing Mental Health Care: A Qualitative Meta-Ethnography
Authors: Reeder Anne L. 
Published: August 2022

ABSTRACT

Overview
This meta-ethnography synthesizes the findings of seven qualitative studies on the experiences of people who are incarcerated in accessing mental health care with a goal of better understanding the scope of these experiences and identifying gaps in custodial mental health care. Noblit and Hare's meta-ethnographic approach was used.

Findings
Five themes were identified: stressful incarceration environments, lack of resources, care is not patient centered, lack of trust, and the value of therapeutic relationships. Findings suggest that the custodial mental healthcare system may provide care that is misaligned with the needs of people who are accessing it.

Limitations
Limitations of this meta-ethnography include the small number of studies identified for review, the diverse foci of the studies, the diversity of the custodial and mental health systems in the four countries from which the studies came, and the unaddressed mixing of jail and prison data in three of the studies.

Implications
Future research should focus on obtaining additional perspectives from people who are accessing custodial mental healthcare services in jail and prison, exploring the differences between the experiences of people in jail versus prison, and identifying ways to develop and maintain high-quality therapeutic relationships between people who are incarcerated and custodial mental healthcare providers, including nurses who work in custodial facilities.
Awareness, Use, and Opinions of Individual Fit Testing of Hearing Protection Devices Among Practicing Michigan Occupational and Environmental Medicine Association Health Care Providers
Authors: Rasmussen Stephanie , Odenigbo Charles , Wang Ling , Wolfe Amir , Rosenman Kenneth 
Published: August 2022

Objective
The aim of this study is to examine the awareness, opinions, and use of individual fit testing of hearing protection devices (HPDs) among occupational medicine practitioners.

Methods
Members of the Michigan Occupational and Environmental Medicine Association completed a 21-question survey on individual fit testing of HPDs.

Results
The survey response rate was 67%, 53% reported having heard of individual fit testing of HPDs, and 24% reported that their clinic/site performed the testing. Major barriers to its use were perceived time to perform (63%), cost (51%), lack of an Occupational Safety and Health Administration requirement (51%), and lack of long-term studies of its effectiveness (20%).

Conclusions
Further work to educate practitioners about the availability, implementation, and potential benefits of fit testing of HPDs is needed if use of this technology is to become more widespread.
Workplace Social Support and Reduced Psychological Distress
Authors: Inoue Reiko , Hikichi Hiroyuki , Inoue Akiomi , Kachi Yuko , Eguchi Hisashi , Watanabe Kazuhiro , Arai Yumi , Iwata Noboru , Tsutsumi Akizumi 
Published: August 2022

Objective
There is little evidence that workplace social support can relieve workers' mental health problems. Therefore, we examined whether social support from coworkers and supervisors was associated with reduced serious psychological distress among employees.

Methods
We used two-wave panel data from 13 Japanese companies. The baseline survey was conducted in 2011, and the follow-up survey 1 year later. From 9889 respondents, we selected 759 who had psychological distress at baseline, defined as ≥13 on the Kessler Psychological Distress Scale (K6).

Results
Increased coworker support was significantly associated with employees' reduced psychological distress (odds ratio, 3.51; 95% confidence interval, 2.17 to 5.68). The association between increased supervisor support and reduced psychological distress was nonsignificant (odds ratio, 1.32, 95% confidence interval, 0.85 to 2.04).

Conclusion
Encouraging coworker support may contribute to the secondary prevention of mental health problems among employees.
Effectiveness of acupuncture in postpartum depression: A protocol for an overview of systematic reviews
Authors: Fan Bu , Zhao Yonghou , Chai Jianbo , Bing Bai , Wang Wanyu 
Published: August 2022

Introduction:Since conflicting evidence from systematic reviews and meta-analyses (SRs/MAs) on the effectiveness of acupuncture in the treatment of postpartum depression is observed. To systematically collate, appraise and synthesize the evidence from these SRs/MAs, an overview will be performed, and this study is an overview protocol.Methods and analysis:Eight databases will be searched: Medicine, Web of science, Cochrane Library, Embase, China National Knowledge Infrastructure, SinoMed, VIP, and Wanfang Data. SRs/MAs of acupuncture on postpartum depression will be included. Literature screening, data extraction, and evaluation of the review quality will be performed by 2 independent reviewers. The methodological quality, reporting quality, and evidence quality will be assessed using the assessment of multiple systematic reviews-2 tool, the preferred reporting items for systematic reviews and meta-analyses checklists, and the grading of recommendations, assessment, development, and evaluation system, respectively. The results will be presented in the context of the topic and the objects of the overview. This study will help bridge the implementation gap between clinical evidence and its translation in clinical application, identify flaws in research and guide future high-quality study.
“I am hesitant to visit the doctor unless absolutely necessary”: A qualitative study of delayed care, avoidance of care, and telehealth experiences during the COVID-19 pandemic
Authors: Moore Ramey , Purvis Rachel S. , Hallgren Emily , Reece Sharon , Padilla-Ramos Alan , Gurel-Headley Morgan , Hall Spencer , McElfish Pearl A. 
Published: August 2022

The COVID-19 pandemic has disrupted the health care system, resulting in decreased health care utilization. During the pandemic, some patients chose to postpone clinic visits or avoid them altogether while health care providers concurrently scaled back their services. As a result, health care has shifted to a greater reliance on telehealth and virtual care.
This study uses a qualitative descriptive design, focused on providing summaries of participant experiences of health care and telehealth utilization during the COVID-19 pandemic.
Three primary themes emerged during analysis: delayed health care, avoidance of care, and experiences of telehealth. Sub-themes of delayed health care included care delays and scheduling difficulties. Participants reported avoidance of health care due to fear of COVID-19 infection, as well as general changes to care-seeking behaviors. Participants also reported positive experiences with telehealth, with some respondents noting limitations of telehealth systems, such as limitations on procedures and patient-centered monitoring of chronic illness.
Our findings support studies that have found both health care delays and changes in health care utilization patterns during the pandemic. Most importantly, this study expands the literature concerning links between fear of COVID-19 and altered care-seeking behaviors, which is the first study to do so focusing on these concerns in the participants’ own words. Finally, while telehealth is promising in preserving continuity of care during pandemics, long-term integration into the health care system is not without challenges, and this study provides insights into how patients experienced telehealth during COVID-19 in their own words.
Data collection, survey design, and research priorities for this study were based on input from ongoing community partnerships.
Risk assessment indicators and brachial-ankle pulse wave velocity to predict atherosclerotic cardiovascular disease
Authors: Ko Hung-Ju , Liu Chuan-Chuan , Hsu Po-Jui , Hu Kuang-Chun , Hung Chung-Lieh , Yu Lo-Yip , Huang Yun-Chieh , Shih Shou-Chuan 
Published: August 2022

Brachial-ankle pulse wave velocity (baPWV) is used for predicting the severity of vascular damage and prognosis of atherosclerotic cardiovascular disease (ASCVD) in people with hypertension and diabetes mellitus. This correlation study aimed to compare the baPWV with other risk indicators for identification of subclinical vascular disease for primary prevention and to determine the clinical utility of baPWV-guided therapy in improving prognosis in high-risk subjects.
We included 4881 subjects who underwent voluntary health examination at Mackay Memorial Hospital, Taiwan between 2014 and 2019. Participants were categorized into the low-risk (<5%), borderline-risk (5%–7.4%), intermediate-risk (7.5%–19.9%), and high-risk (≥20%) groups based on the 10-year risk for ASCVD. The predictive risk criteria, that is, the metabolic syndrome score, Framingham Risk Score, estimated glomerular filtration rate, and baPWV were compared among these groups. The chief cause of induced responses and the relationships between parameters were identified using principal component analysis. The participants’ ages, body mass index, systolic, diastolic blood pressure, triglycerides, fasting glucose, hemoglobin A1c, creatinine, neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, metabolic syndrome, Framingham Risk Score, and age-related arterial stiffness (vascular age) increased significantly from the low-risk to high-risk groups (P < .001). The mean estimated glomerular filtration rate decreased significantly from the low- to high-risk groups (P < .001). The predicted vascular age and actual age differed significantly between the intermediate- and high-risk groups (P < .001). High-density lipoprotein levels plummeted significantly among the 4 groups (P < .001). The right and left baPWV and ankle brachial index differed significantly among the 4 groups (all P < .001) and increased from the low-risk to high-risk groups (P < .001). Carotid Doppler ultrasonography revealed a significant increase in plaque formation (23.5%, 35.4%, 46.3%, and 61.5% for the low-, borderline-, intermediate, and high-risk groups, respectively). The total explanatory variation was 61.9% for 2 principal variation factors (baPWV, 36.8% and creatinine, 25.1%). The vascular age predicted using baPWV greatly exceeded the chronological age. Plaque formation was significant even in the low-risk group, and its frequency increased with the predicted ASCVD risk. Risk indicators and baPWV are useful predictors of ASCVD, which in conjunction with conventional pharmacotherapy could be useful for primary prevention of plaque formation in subjects with cardiovascular comorbidities.
Neonatal nutritional risk and pulmonary function
Authors: Zhang Xiaoyan , Liu Junhong , Xu Shuzheng , He Fei , Huang Huanhuan , Wu Bin 
Published: August 2022

Introduction:
The neonatal period is a critical initial stage of postnatal lung development and maturation. This study aimed to investigate the effects of the nutritional status on pulmonary function in late preterm and full-term neonates.

Methods:
A total of 172 newborns were included in the study. Nutritional risk screening, weight measurement, assessment of albumin and caloric intake, and a pulmonary function examination were conducted on the 7th day after birth.

Results:
There was a significant correlation between the nutritional risk and changes in body weight. Tidal volume (VT), minute ventilation (MV), VT per kg body weight (VT/kg), and MV per kg body weight (MV/kg) in the low nutritional risk group were significantly higher than those in the medium nutritional risk group (all P < .05). Albumin and caloric intake in the low nutritional risk group were significantly higher than those in the medium nutritional risk group (both P < .01). VT, VT/kg, MV, and MV/kg in the weight loss group were lower than those in the no weight loss group (all P < .05).

Conclusions:
Changes in neonatal weight mainly affect lung volume (VT, VT/kg, MV, and MV/kg), suggesting that an improvement in the neonatal nutritional status is important for the development of lung volume.
Biologic DMARDs and targeted synthetic DMARDs and the risk of all-cause mortality in rheumatoid arthritis: A systematic review and meta-analysis
Authors: Pang Mengduan , Sun Zhe , Zhang Hongfeng 
Published: August 2022

Background:
The aim of this study was to perform a meta-analysis to compare the risk of all-cause mortality between biological/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) and non-b/tsDMARDs involving patients with rheumatoid arthritis (RA).

Methods:
We performed a systematic review of articles published up to August 2021 using electronic databases. We included studies that reported all-cause mortality in RA patients and compared b/tsDMARDs and non-b/tsDMARDs.

Results:
We included a total of 77 studies involving 64,428 patients. These comprised 44,227 patients treated with b/tsDMARDs and 20,201 treated with non-b/tsDMARDs. The occurrence of all-cause mortality was the primary outcome. The risk of all-cause mortality between the 2 treatments was not significantly different (relative risk = 1.08; 95% confidence interval = 0.98–1.19). However, subgroup analyses showed significant increase in risks of mortality in anti-TNFs users with RA compared with non-b/tsDMARDs (relative risk = 1.47, 95% confidence interval = 1.02–2.12). No significant differences were found after subgroup analyses based on other molecules involved and study duration.

Conclusion:
In comparison with non-b/tsDMARDs, our results suggest that antitumor necrosis factor therapy is associated with observed increased risks of mortality and further investigation is needed.
Effects of idiopathic erythrocytosis on the left ventricular diastolic functions and the spectrum of genetic mutations: A case control study
Authors: Yesilaltay Alpay , Degirmenci Hasan , Bilgen Turker , Sirin Duygu Yasar , Bayir Duygu , Degirmenci Pelin , Tekinalp Atakan , Alpsoy Seref , Okuturlar Yildiz , Turgut Burhan 
Published: August 2022

Background:
We have aimed at exposing left ventricular diastolic functions and the presence of known genetic mutations for familial erythrocytosis, in patients who exhibit idiopathic erythrocytosis.

Methods:
Sixty-four patients with idiopathic erythrocytosis (mean age, 46.4 ± 2.7 years) and 30 age-matched healthy subjects were prospectively evaluated. The regions of interest of the erythropoietin receptor, hemoglobin beta-globin, von Hippel-Lindau, hypoxia-inducible factor 2 alpha, and Egl-9 family hypoxia-inducible factor genes were amplified by PCR. Left ventricular (LV) mass was measured by M-mode and 2-dimensional echocardiography. LV diastolic functions were assessed by conventional echocardiography and tissue Doppler imaging.

Results:
As a result of genetic analyses, genetic mutations for familial erythrocytosis were detected in 5 patients. It has been observed in our study that the risk of cardiovascular disorders is higher in patients. Interventricular septum thickness, left atrial diameter, and some diastolic function parameters such as deceleration time and isovolumetric relaxation time have been found to be significantly higher in idiopathic erythrocytosis group than in the controls.

Conclusion:
This study has shown that LV diastolic functions were impaired in patients with idiopathic erythrocytosis. In this patient group with increased risk of cardiovascular disorders, the frequent genetic mutations have been detected in 5 patients only. Therefore, further clinical investigations are needed as novel genetic mutations may be discovered in patients with idiopathic erythrocytosis because of cardiovascular risk.
Comprehensive treatment outcomes of giant cell tumor of the spine: A retrospective study
Authors: Hashimoto Kazuhiko , Nishimura Shunji , Miyamoto Hiroshi , Toriumi Kensuke , Ikeda Terumasa , Akagi Masao 
Published: August 2022

There is no consensus on a treatment strategy for spinal giant cell tumor of bone (GCTB) because of the difficulty in their treatment. Treatment options often include the use of the controversial denosumab, an antibody therapy aimed at tumor shrinkage, different curettage techniques, resection, or a combination of these therapies. The current study aimed to identify treatment methods associated with favorable outcomes in patients with spinal GCTB.
We retrospectively reviewed 5 patients with spinal GCTB, including patients with tumors of the sacrum, treated at our hospital between September 2011 and November 2020. Two men and 3 women were included in the study. The median follow-up period was 74 months (range: 14–108 months). We surveyed the tumor site, treatment method, denosumab use, and outcomes.
The median age was 17 years (range: 17–42 years). There were 2 cases of sacral GCTB and 1 case each of lumbar, cervical, and thoracic vertebral GCTB. The comorbidities observed included hepatitis, malignant lymphoma, atopic dermatitis, and asthma. The treatment method included zoledronic acid after embolization and denosumab, denosumab only, curettage and posterior fusion, and curettage resection after embolization and anterior and posterior fusion. Denosumab was used in all cases. Three patients were continuously disease-free, 1 patient with no evidence of disease, and 1 patient alive with disease.
Aggressive treatment, especially surgical treatment, may lead to good results in spinal GCTB.