bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construction of Ni‐Co‐Fe Hydr(oxy)oxide@Ni‐Co Layered Double Hydroxide Yolk‐Shelled Microrods for Enhanced Oxygen Evolution
Authors: Niu Qian , Yang Min , Luan Deyan , Li Nian Wu , Yu Le , Lou Xiong Wen (David) 
Published: October 2022

AbstractThe exploration of earth‐abundant and efficient electrocatalysts toward the oxygen evolution reaction (OER) is critical for sustainable energy storage and conversion devices. In this work, we report a self‐engaged strategy to fabricate a yolk‐shelled OER electrocatalyst. Starting with a metal–organic framework, Co‐Fe layered double hydroxide (LDH)@zeolitic imidazolate framework‐67 (ZIF‐67) yolk‐shelled structures are formed in one step. Afterwards, these ZIF‐67 building blocks are transformed into Ni‐Co LDH nanocages to form the Ni‐Co‐Fe hydr(oxy)oxide@Ni‐Co LDH yolk‐shelled microrods (NiCoFe‐HO@NiCo‐LDH YSMRs) through an ion‐exchange reaction. Owing to the structural and compositional merits, the NiCoFe‐HO@NiCo‐LDH YSMR electrocatalyst exhibits an overpotential of 278 mV to reach the current density of 10 mA cm−2, a small Tafel slope of 49.7 mV dec−1, and good stability in alkaline media.
High‐Efficiency CO2/N2 Separation Enabled by Rotation of Electrostatically Anchored Flexible Ligands in Metal–Organic Framework
Authors: Qu Kai , Huang Kang , Xu Jipeng , Dai Liheng , Wang Yixing , Cao Hongyan , Xia Yongsheng , Wu Yulin , Xu Weiyi , Yao Zhizhen , Guo Xuhong , Lian Cheng , Xu Zhi 
Published: October 2022

AbstractMetal organic frameworks (MOF) are of great potential for molecular separation, but the ligand rotation flexibility makes them remain challenging in the construction of fixed nanochannels for precise sieving. Here we report an electrostatic‐anchoring strategy to fix the rotation of 2‐methylimidazole (2‐MIM) ligand in ZIF‐8. Electrostatic inducer trifluoroacetate anchored at and blocked the six‐membered windows of ZIF‐8, and meanwhile induced the positive 2‐MIM rotated from initial 49° to 68°, thus opening neighbored four‐membered windows with a constant size of 3.4 Å. The obtained ZIF‐8 significantly enhanced the CO2/N2 adsorption selectivity from 14.02 to 332.86. Further membrane‐based separation exhibited an outstanding CO2/N2 selectivity of up to 137 with a desired permeability of 286 Barrer, which exceeded the 2019 upper bound. This strategy provides a new inspiration for fixing the ligand rotation in soft MOF for desired precise molecular sieving.
The Role of Metal Adatoms in a Surface‐Assisted Cyclodehydrogenation Reaction on a Gold Surface
Authors: Björk Jonas , Sánchez‐Sánchez Carlos , Chen Qiang , Pignedoli Carlo A. , Rosen Johanna , Ruffieux Pascal , Feng Xinliang , Narita Akimitsu , Müllen Klaus , Fasel Roman 
Published: October 2022

AbstractDehydrogenation reactions are key steps in many metal‐catalyzed chemical processes and in the on‐surface synthesis of atomically precise nanomaterials. The principal role of the metal substrate in these reactions is undisputed, but the role of metal adatoms remains, to a large extent, unanswered, particularly on gold substrates. Here, we discuss their importance by studying the surface‐assisted cyclodehydrogenation on Au(111) as an ideal model case. We choose a polymer theoretically predicted to give one of two cyclization products depending on the presence or absence of gold adatoms. Scanning probe microscopy experiments observe only the product associated with adatoms. We challenge the prevalent understanding of surface‐assisted cyclodehydrogenation, unveiling the catalytic role of adatoms and their effect on regioselectivity. The study adds new perspectives to the understanding of metal catalysis and the design of on‐surface synthesis protocols for novel carbon nanomaterials.
Side‐Chain Control of Topochemical Polymer Single Crystals with Tunable Elastic Modulus
Authors: Wei Zitang , Wang Xiaokang , Seo Bumjoon , Luo Xuyi , Hu Qixuan , Jones Jack , Zeller Matthias , Wang Kang , Savoie Brett M. , Zhao Kejie , Dou Letian 
Published: October 2022

AbstractTopochemical polymerizations hold the promise of producing high molecular weight and stereoregular single crystalline polymers by first aligning monomers before polymerization. However, monomer modifications often alter the crystal packing and result in non‐reactive polymorphs. Here, we report a systematic study on the side chain functionalization of the bis(indandione) derivative system that can be polymerized under visible light. Precisely engineered side chains help organize the monomer crystals in a one‐dimensional fashion to maintain the topochemical reactivity. By optimizing the side chain length and end group of monomers, the elastic modulus of the resulting polymer single crystals can also be greatly enhanced. Lastly, using ultrasonication, insoluble polymer single crystals can be processed into free‐standing and robust polymer thin films. This work provides new insights on the molecular design of topochemical reactions and paves the way for future applications of this fascinating family of materials.
Organic Electrolyte Design for Rechargeable Batteries: From Lithium to Magnesium
Authors: Zhang Heng , Qiao Lixin , Armand Michel 
Published: October 2022

AbstractRechargeable magnesium batteries (RMBs) have been considered as one of the most viable battery chemistries amongst the “post” lithium‐ion battery (LIB) technologies owing to their high volumetric capacity and the natural abundance of their key elements. The fundamental properties of Mg‐ion conducting electrolytes are of essence to regulate the overall performance of RMBs. In this Review, the basic electrochemistry of Mg‐ion conducting electrolytes batteries is discussed and compared to that of the Li‐ion conducting electrolytes, and a comprehensive overview of the development of different Mg‐ion conducting electrolytes is provided. In addition, the remaining challenges and possible solutions for future research are intensively discussed. The present work is expected to give an impetus to inspire the discovery of key electrolytes and thereby improve the electrochemical performances of RMBs and other related emerging battery technologies.
A skin patch integrating swellable microneedles and electrochemical test strips for glucose and alcohol measurement in skin interstitial fluid
Authors: Zheng Mengjia , Zhang Yuyue , Hu Tianli , Xu Chenjie 
Published: October 2022

AbstractMicroneedle (MN)‐based diagnostic devices can efficiently access skin interstitial fluid (ISF) for accurate and minimally invasive detection of health‐related biomarkers. This work reports a biomarker (i.e., glucose or alcohol) monitoring MN device that is composed of swellable MNs and electrochemical test strip. This device is constructed by adhering MN patch on the electrochemical strips using the chitosan as the connecting layer. The MNs penetrate the skin for extraction of ISF that flows to the backing layer of MNs and is analyzed by the test strip. In the in vitro skin models, this device accurately detects the glucose from 0 mM to 12 mM and alcohol from 0 mM to 20 mM. In vivo experiment shows this MN device is capable of minimally invasive sampling of ISF and analysis of glucose levels to determine the glycemic status of mice.
High MutS homolog 2 expression predicts poor prognosis and is related to immune infiltration in endometrial carcinoma
Authors: Lu Xiaoqin , Ying Yanqi , Zhang Wenyi , Li Rui , Zhang Jingyan 
Published: October 2022

AbstractSeveral studies have shown that MutS homolog 2 (MSH2) is highly expressed in many cancer tissues. Transcriptome expression data were collected from the Cancer Genome Atlas (TCGA) database. We analyzed the expression of MSH2 in normal and tumor tissues, the relationship between MSH2 expression and various prognostic factors, and the relationship between MSH2 expression and overall survival, disease specific survival, and progression free interval. We also examined MSH2 promoter methylation between endometrial cancer and normal endometrial tissues, and identified the prognostic value of MSH2 methylation in endometrial cancer. MSH2 was highly expressed in endometrial cancer tumor tissues compared with normal tissues. High MSH2 expression might be an independent prognostic factor for OS, DSS, and PFI. Further, high MSH2 expression was correlated with age and histological type, but not with BMI, clinical stage, tumor invasion, or other clinical features. MSH2 promoter methylation in endometrial cancer was significantly lower than in normal tissues. Additionally, MSH2 levels, OS, DSS, and PFI were associated with BMI, age, tumor invasion, and histological type. ssGSEA showed that MSH2 expression was positively correlated with the infiltration of Th2 cells, Tcm cells, T helper cells, and Tgd cells, whereas it was negatively correlated with NK CD56 bright cells, pDC cells, iDC cells, cytotoxic cells, and neutrophils. Increased MSH2 expression and reduced MSH2 methylation in endometrial cancer predicts poor prognosis. MSH2 may be used as a biomarker for the diagnosis and prognosis of endometrial cancer and as an immunotherapy target.
Parietal bone osteoid osteoma: A rare cause of button sequestrum sign in pediatrics. Case report and review of literature
Authors: Mehri Ali , SeilanianToosi Farrokh , Samini Fariborz , Akhondian Javad , Khooei Ali Reza , Hashemi Narges 
Published: October 2022

AbstractThe current study evaluates a rare case of parietal bone osteoid osteoma in pediatrics and review the differential diagnosis of button sequestrum sign in the literature. A 12‐year‐old girl expressed localized pain in the right parietal bone. MRI represented enhancing nodule with button sequestrum sign appearance.
Acral blisters in neonates: Three rare and benign diseases
Authors: Rekik Mariem , Regaieg Chiraz , Sellami Khadija , Khanfir Habiba , Kolsi Nadia , Baklouti Massara , Amouri Mariem , Masmoudi Abderrahman , Ben Thabet Afef , Gargouri Abdellatif , Turki Hamida 
Published: October 2022

AbstractExclusive acral involvement in neonatal pemphigus is unusual. Blisters in neonatal bullous pemphigoid, affecting 2%–3% of newborns of mothers with gestational pemphigoid, can be located in the trunk, limbs and acral areas. Unlike neonatal bullous pemphigoid, which can appear up to 5 days after birth, neonatal pemphigus is often revealed at birth. They are benign diseases in newborns. There is no correlation between the disease severity in babies and mothers. Neonatal risk is dominated by the side effects of corticosteroid therapy.
Omphalolith: An underdiagnosed entity
Authors: Jouini Wafa , Litaiem Noureddine , Zaimi Yosra , Mouelhi Leila , Debbeche Radhouane , Zeglaoui Faten 
Published: October 2022

AbstractOmphalolith is a rare and underdiagnosed entity due to the accumulation of sebum and keratin in the umbilicus. It usually occurs in the elderly with deep and narrow umbilicus. Early recognition of omphalolith is important to prevent complications, unnecessary investigations, and anxiety. We report herein two new cases of omphalolith.
Telemedicine allows for effective communication between a medically complex cancer patient and his virtual hospital medical team
Authors: Paulson Margaret R. , Torres‐Guzman Ricardo A. , Avila Francisco R. , Maita Karla C. , Forte Antonio J. , Butera Julie E. , Maniaci Michael J. 
Published: October 2022

AbstractGood physician–patient communication is key for effective hospital care. We describe a patient diagnosed with an acute pulmonary embolism and bacteremia who was treated in a virtual hybrid hospital‐at‐home program. Constant communication with the virtual and in‐home healthcare teams enabled a unified knowledge of the patient's wishes.
Regioselectivity Inversion of an O‐Methyltransferase via Semi‐rational Mutagenesis Combined with Metal Ion Substitution
Authors: Su Ying , Li Hai‐Peng , Zhang Man , Ding Xu‐Wei , Xu Jian‐He , Chen Qi , Zheng Gao‐Wei 
Published: October 2022

AbstractS‐adenosyl‐L‐methionine (SAM)‐dependent O‐methyltransferases (O‐MTs) are a class of valuable and attractive biocatalysts for alkylation of catechols. In this work, an O‐methyltransferase (GeOMT) from the plant Galanthus elwesii was identified and characterised. GeOMT methylated a series of catechols with excellent regioselectivity. Moreover, a strategy was developed that combines structure‐directed protein engineering and metal ion substitution for regioselective inversion of GeOMT. The resultant W50M/A53N/Y186K triple variant preferentially coordinated Ni2+ instead of Mg2+ and displayed almost complete inversion in regioselectivity from 1 : 99 to 94 : 6 (para/meta) for 4‐nitrocatechol, the para‐methylated product of which is a vital plant growth regulator. This represents a promising strategy for regioselectivity improvement of O‐MTs.
Enhancement of the Photocatalytic Oxygen Production by Tantalum Nitride Supported Fe Atom Embedded N‐Doped Graphene Oxide†
Authors: Chen Hanxiang , Yan Jia , Mo Zhao , Liu Jinyuan , Zhu Xianglin , Li Huaming , Xu Hui 
Published: October 2022

Comprehensive SummaryEnergy crises and environmental pollution have become urgent problems with human civilization development. Photocatalysis technology is a green method to deal with these challenges. The key to improve photocatalytic efficiency lies in the effective separation of photogenerated electron–hole pairs. In this work, we designed the Fe atom embedded N‐doped graphene oxide (Fe‐NGO) supporting on tantalum nitride (Ta3N5) catalyst, which was employed to improve the photocatalytic oxygen production activity. The oxygen production of 5 wt% Fe atom embedded N‐doped graphene oxide supporting on tantalum nitride (Fe‐NGO/Ta3N5) was 184.7 μmol·g−1, about 3.5 times higher than that of the pure Ta3N5. The introduction of the cocatalyst Fe‐NGO acting as an electron conductor in the Fe‐NGO/Ta3N5 accelerates the carrier migration of Ta3N5 and further enhances the photocatalytic oxygen production activity. N‐doping increases the conductivity of graphene oxide (GO), and Fe atoms are used as the reactive sites to promote the combination of electron and sacrificial agent in the system. This work may provide insights into the research of new carbon cocatalyst materials.
Deep targeted sequencing of cytological tumor cells using whole genome amplification
Authors: Amemiya Kenji , Hirotsu Yosuke , Mochizuki Hitoshi , Higuchi Rumi , Nakagomi Takahiro , Goto Taichiro , Oyama Toshio , Kondo Tetsuo , Omata Masao 
Published: October 2022

AbstractBackgroundGenomic profiling in lung cancer is essential for precision medicine. Cytological specimens provide an alternative to formalin‐fixed paraffin‐embedded (FFPE) samples for comprehensive genomic analysis. However, this approach remains challenging when a limited number of tumor cells are available. We applied whole genome amplification (WGA) to cytology specimens to overcome this limitation.MethodsUsing a lung cancer panel targeting 58 genes, we performed next‐generation sequencing of whole genome‐amplified DNA extracted from cytological specimens containing 10–20 tumor cells (cyto‐WGA) and DNA from corresponding FFPE tumor tissue. We compared sequencing data from cyto‐WGA and FFPE samples to examine the detection accuracy of copy number variations and oncogenic and drug‐matched variants.ResultsThe DNA quality and quantity from cyto‐WGA were higher than those from FFPE samples (p < .0005 and p < .05, respectively). Sequencing metrics of cyto‐WGA and FFPE tissues showed no difference in the number of mapped reads and mean coverage depth, but there were significant differences in the on‐target rate (p < .05) and uniformity (p < .0005). Copy number variations in cyto‐WGA samples (n = 211) were higher than in FFPE samples (n = 9) (p < .0001). Fourty nine oncogenic variants were detected in cyto‐WGA and 39 in FFPE. Of these variants, 34 (63%) were present in both samples. In addition, all 16 drug‐matched variants were detected in FFPE and cyto‐WGA samples with 100% concordance.ConclusionCyto‐WGA can be a feasible and alternative method to detect oncogenic and drug‐matched variants.
First‐in‐Human Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E6742, a Dual Antagonist of Toll‐like Receptors 7 and 8, in Healthy Volunteers
Authors: Yamakawa Naoto , Tago Fumitoshi , Nakai Kenya , Kitahara Yasumi , Ikari Shingo , Hojo Seiichiro , Hall Nancy , Aluri Jagadeesh , Hussein Ziad , Gevorkyan Hakop , Maruyama Tatsuya , Ishizaka Sally , Yagi Takuya 
Published: October 2022

AbstractThe first‐in‐human phase I study for E6742, a dual toll‐like receptor (TLR) 7 and TLR8 antagonist, has been conducted to assess the safety, tolerability, and pharmacokinetics of E6742 in healthy volunteers. In a single ascending dose (SAD) study, 42 subjects received 10–800 mg of E6742 in the fasted state, as well as a 100‐mg cohort in the fed state for evaluating the effect of food. In a multiple ascending dose (MAD) study, 18 subjects received 100–400 mg of E6742 twice daily for 7 days. E6742 was rapidly absorbed with a median tmax ranging from 1.50 to 2.50 hours across dose groups under the fasted condition, and eliminated with a median t½ ranging from 2.37 to 14.4 hours. After multiple oral doses, a steady state was reached by day 7. In the SAD study, dose proportionality was observed for Cmax, AUC(0‐t), and AUC(0‐inf) values of E6742 up to 800 mg, but these values were slightly less than dose proportional at 10 mg. In the MAD study, the Cmax and AUC(0‐12h)ss of E6742 appeared to be almost dose proportionally increased between 100 and 200 mg, while these parameters showed more than a dose proportional increase at 400 mg. In addition to safety and good tolerability, this study demonstrated cytokine concentrations in cultured peripheral blood in response to E6742 were suppressed in a dose‐dependent manner. Further clinical studies targeting systemic lupus erythematosus patients are currently underway.
Elucidating the Implications of Diverse Dynamical Responses in p53 Protein
Authors: Charan Kajal , Giri Amitava , Kar Sandip 
Published: October 2022

Abstractp53 is a well‐known tumor suppressor gene that acts as a transcription factor to exhibit a variety of dynamical responses by sensing different types and extent of stress conditions causing DNA damage in Mammalian cells. Mathematical modeling has played a crucial role to correlate cell fate decision‐making with some of these dynamic p53 regulations. However, it is extremely challenging to explain the various cell‐type and stimulus‐specific p53 protein dynamics under different stress conditions by using a single mathematical model. In this article, we propose a simple mathematical model of p53 regulation based on a generic p53 regulatory network that elucidates a range of p53 dynamical responses. By employing bifurcation analysis along with deterministic and stochastic simulations, we explain an array of p53 dynamics by correlating it with the corresponding cell fate regulations in a cell type‐specific and stimulus‐dependent manner. Moreover, our model makes experimentally testable predictions to fine‐tune p53 dynamics under various DNA damage conditions and can be systematically used and improved to analyze complex p53 dynamics in the future.
Thermal damage and excision time of micro and super pulsed diode lasers: A comparative ex vivo analysis
Authors: Prado Mariliza C. O. , Nwizu Ngozi N. , Patel Shalizeh A. , Streckfus Charles F. , Zezell Denise Maria , Barros Juliana 
Published: October 2022

AbstractObjectivesThe primary aim of this ex vivo study was to evaluate thermal damage and cutting efficiency of micro and super pulsed diode lasers. The secondary aim was to suggest a guideline to perform simple surgical excisions adequate for histopathological evaluation.Material and MethodsTen groups of 10 specimens of pig tongues were excised using a blade (G1), a micro pulsed (G2–G9), and a super pulsed diode (G10) lasers. Different output power, pulse duration, pulse interval, and duty cycle were tested. Quantitative measures of thermal damage and excision times were recorded. Statistical analysis was performed at a significance level of 5%.ResultsThe control group (G1) presented no thermal damage. Within the laser groups (G2–G10), no statistically significant differences in depth of thermal damage (µm) were noted. G3 showed significantly less area of thermal damage (mm2) when compared with G7 and G9 (p < .05). The median excision time of the control group and super pulsed diode laser group were significantly lower (p < .001) than the micro pulsed diode laser groups.ConclusionsThe cutting efficiency of the super pulsed diode laser is comparable to traditional blade, and with appropriate parameters, these lasers can produce predictable surgical outcomes with less collateral damage.
SIRT1/Notch1 signal axis involves in the promoting effect of Segetalin B on bone formation
Authors: Lan Xiaoyong , Ma Haiping , Cheng Qingfeng , Xiao Yuhong , Zou Lingfeng , Yuan Zhen , Luo Jun 
Published: October 2022

AbstractPhytoestrogens are a class of potential natural medicines for treating postmenopausal osteoporosis (PMOP). Segetalin B (SB) is a cyclic peptide compound showing estrogenic activity. This study reports the effect of SB on bone formation among ovariectomized (OVX) rats. The bone marrow mesenchymal stem cells (BMSCs) from OVX rats were cultured in vitro. Alizarin Red staining was utilized to observe the effect of SB on the mineralization of BMSCs. The levels of alkaline phosphatase (ALP), osteocalcin, bone morphogenetic protein (BMP‐2), and Sirtuin 1 (SIRT1) activities were detected. The OVX rats were treated with SB in vivo. Micro‐CT was utilized for imaging analysis. Urine calcium and phosphorus, and ALP activity in bone marrow were assayed. Western blot analysis and immunofluorescence were incorporated to detect protein expressions in vitro and in vivo. The results showed that SB dose‐dependently promoted mineralization of OVX rat‐derived BMSCs in vitro increased the level of Osteocalcin, BMP‐2, ALP, and SIRT1 activity. Moreover, it upregulated expressions of Runx2, Osterix, and SIRT1, downregulated expressions of Notch intracellular domain (NICD), acetyl‐NICD, and hairy and enhancer of split 1 (Hes1). In addition, SB treatment significantly decreased bone loss, inhibited calcium and phosphorus loss, elevated ALP activity, upregulated Runx2, Osterix, and SIRT1, and downregulated NICD and Hes1 in OVX rats in vivo. However, EX527, a SIRT1‐selective inhibitor, could reverse the above effects of SB in vitro or in vivo. These results indicate that SB is a potential natural medicine to improve PMOP. Thus, its mechanism of promoting bone formation involves the SIRT1/Notch1 signaling axis.