bluuebunny/crossref_metadata_2025_split huggingface dataset:
Residues determination, risk assessment, half-life and dissipation behaviour of flusilazole formulation
Authors: AMIN ZAKIR , Sheikh Parveez Ahmad , Jan Ishrat , Summuna Baby , Mohiddin Fayaz A. 
Published: November 2022

Abstract
To determine the risk assessment, half‑life and waiting period of flusilazole on apple fruit (Malus Domestica Borkh.) under temperate conditions of Kashmir, India, Flusilazole 40 EC was applied on Red Velox apple trees two months prior to harvest at 80 g a.i. ha-1 (recommended) and 160 g a.i. ha-1. The analytical samples of flusilazole were analysed by high-performance liquid chromatography (HPLC) through a reverse phase. Recovery percentage of flusilazole at three fortification levels (0.5, 1.0 & 1.5 ppm) were found to be 110.70, 97.33 and 103.16%, respectively. Flusilazole at the recommended dose (80 g a.i. ha-1) left an initial deposit of 0.733 ppm which dissipated by 93.45% in 60 days and was non-detectable beyond this period. While flusilazole at double the recommended dose (160 g a.i. ha-1) left an initial deposit of 0.913 ppm which dissipated by 93.43% in 70 days and was non-detectable beyond this period. Based on the maximum residue limit of 0.3 ppm as prescribed by the Codex Alimentarius Commission, a waiting period of 28.74 days and 46.03 days were recorded for single and double doses, respectively. Moreover, in order to assess the consumer risk, theoretical maximum residue contributions (TMRC) were derived using flusilazole residues (average and maximum) recorded at various time intervals and compared to the maximum permissible intake (MPI) and consequently an acceptable daily intake (ADI) of 0.001 mg kg-1 body weight/day can be recommended. The MPI was determined by multiplying the recommended ADI with the average person's weight (60 kg) and was found to be 0.006 mg person-1 day-1. Based on the average per capita daily consumption of 6.76 g apple in India, the TMRC values were found to be (0.0049 and 0.00534 mg day-1 person-1) and (0.0061 and 0.0062 mg day-1 person-1) for average and maximum flusilazole residues at single and double dose, respectively. The TMRC values were far less than MPI at both doses of application at 0 day; therefore, the consumer health risks are minimal even at double the recommended dosage.
An approach to local electron energy in atoms through Rényi's entropy
Authors: Flores-Gallegos Nelson 
Published: November 2022

Abstract
In this work, it is presented an approach to the local electron energy of the first thirty-six atoms in their ground state using Rényi's entropy is defined in terms of the electron density in position and momentum spaces. To carry out our study, we calculated and compared the trends obtained from the local functionals of kinetic, exchange, and Coulomb energy, with Rényi's entropy. Our results suggest that Rényi's entropy could be a good option to perform studies on the local behavior of the energy in atoms and also in studies on the electron correlation phenomenon.
Nickel Smelter on Social-Economics and Environmental Issues
Authors: Taufik Yani , Adijaya Sarlan , Rela Iskandar Zainuddin 
Published: November 2022

Abstract
As one of the countries in the world with large nickel reserves, Indonesia can use this wealth of mineral resources to accelerate development and improve people's welfare. However, like the management of mineral resources in other countries, mineral exploration has a side effect on the environment and people's lives, especially those who live around the mines. This study reveals the environmental and socio-economic impacts that occur at the smelter construction site in Bahodopi Sub-district, Morowali Regency Central Sulawesi Province of Indonesia. The existence of nickel plant has become a magnet for migrants, the drying up of several rivers, degradation of forest functions and sedimentation along the coast, has forced local residents to join migrants in pursuing new livelihoods in the trade and service sector, leaving their previous livelihoods as farmers and fisherman. It cannot be denied that there has been an increase in GDP from the mining sector, but it has not been used optimally to repair environmental damage and socio-economic impacts caused by mining activities.
Drilling percutaneously through the nonunion site: a more cost effective solution for long bone nonunions
Authors: Yin Bing , Lu Bo , Wang Tianci , Zhang Yingze , Guo Jialiang 
Published: November 2022

Abstract
Background: Despite the development of improved fracture treatment, bone nonunion remains a challenge for orthopedic surgeons. Various therapies have been examined for the treatment of nonunions, including fixator exchange, bone grafting, application of growth factors, and even cell and gene therapy. However, all these methods have limitations, such as donor site complications, soft tissue problems, high cost and long hospitalization. This study aims to find a minimally invasive and cost-effective method for nonunion treatment.
Methods: Between October 2018 and October 2019, nineteen patients with long bone nonunions (11 tibia and 8 femur) were treated in our trauma center. There were 14 males and 5 females and the average age was 56.1 years. Treatment of the nonunion was performed by a novel technique consisting of a direct drilling procedure. Under C-arm guidance, a k-wire was used to percutaneously drill across the nonunion site. The k-wire was directed along the longitudinal axis of the bone. The necrotic cortex of the nonunion site was drilled and the medullary cavity was re-established. The implants were maintained, as the fixation was stable. Regular rehabilitation and follow-up was performed until the patient achieved bone union.
Results: 18 of the 19 cases achieved succesful bony union with this technique. Sixteen achieved union after a single drilling procedure, while two patients required a second drilling procedure to achieve union. One failure occurred in a female patients with a tibial shaft nonunion which only achieved union after revision fixation and cancellous bone grafting. The average union time after drilling technique was 7.4 month (range: 4-14), and the average hospital stay was 5.3 days (range: 4-15).
Conclusion: This drilling technique provides a novel, minimally invasive, effective and low-cost method for the treatment of bone nonunion. It minimizes the iatrogenic damage and preserves the biological environment for fracture healing. The encouraging results of this technique warrants a larger study.
Trial registration: Chinese Clinical Trial Registry ChiCTR-PPC-14005360. Registered 17 October 2014
Solitary Extensor Tendon in the Third Compartment has a Companion: Variant Course of Extensor Pollicis Brevis in Third Extensor Compartment.
Authors: Rangarajan Aadithya , K.G Bhaskara 
Published: November 2022

Abstract
Anomalous variants of the extensor tendons in the first and third compartments of the wrist have been described following cadaveric study. Being aware of such variants during either an elective or emergency hand surgery will prove beneficial in the execution of the extensor tendon repairs. A very few clinical reports are available in the literature. We report a rare finding of Extensor Pollicis Brevis tendon accompanying the solitary Extensor Pollicis Longus tendon in the third compartment observed during an emergency trauma surgery.
How do practitioners prescribe exercise to patients with breast cancer? Professional perspectives on the implementation of aerobic exercise guidelines for patients with breast cancer undergoing chemotherapy.
Authors: Murray James , Bennett Hunter , Perry Rebecca , Bezak Eva , Davison Kade 
Published: November 2022

Abstract
Purpose:
The benefits of exercise for cancer are well established. However, how experienced accredited exercise physiologists (AEPs) and medical professionals implement exercise guidelines when prescribing/recommending aerobic exercise to patients with breast cancer undergoing chemotherapy remains unknown.
Methods:
A four round, two phase, survey was conducted. Four cancer-specific AEPs, four oncologists, and one breast cancer surgeon (median 13-yr breast-cancer-specific experience) completed phase one. Eighty-four AEPs (median 5-yr experience) completed phase two. Phase one participants answered open- and close-ended questions regarding how they implement cancer-specific aerobic exercise guidelines for patients with breast cancer patients undergoing chemotherapy, and what information they believe should be collected to guide exercise prescription. All questions agreed upon in phase one (>70% rating 7-9 on a 0-9 Likert Scale) were rated by AEPs in phase two.
Results:
Subjective questioning by AEPs should consider the stage, type, and location of breast cancer, treatments, side effects, and exercise preferences and expectations. Objective assessment should include upper-arm circumference, strength, and range of motion. Separating aerobic exercise into 5-to-9-minute bouts was considered appropriate and exercising to exhaustion should be avoided. Exercise intensity and duration should be adjusted throughout chemotherapy to improve tolerance and adherence.
Conclusion:
This study identifies how professionals approach exercise assessment and prescription in patients with breast cancer undergoing chemotherapy. These findings can help guide practice and inform future guidelines.
Implications for Cancer Survivors:
This research helps exercise professionals make better decisions when prescribing exercise to patients with breast cancer undergoing chemotherapy, improving the quality of care for this population.
Krüppel-like factor 9 (KLF9) links hormone dysregulation and circadian disruption to breast cancer pathogenesis
Authors: Ybañez Weand , Bagamasbad Pia 
Published: November 2022

Abstract
Background: Circadian disruption is an emerging driver of breast cancer (BCa), with epidemiological studies linking shift work and chronic jet lag to increased BCa risk. Indeed, several clock genes participate in the gating of mitotic entry, regulation of DNA damage response, and epithelial-to-mesenchymal transition, thus impacting BCa etiology. Dysregulated estrogen (E2; 17b-estradiol) and glucocorticoid (GC; cortisol, CORT) signaling prevalent in BCa may further contribute to clock desynchrony by directly regulating the expression and cycling dynamics of genes comprising the local breast oscillator. In this study, we investigated the tumor suppressor gene, KLF9, as an important point of crosstalk between hormone signaling and the circadian molecular network, and further examine its functional role in BCa.
Methods: Through meta-analysis of publicly available RNA- and ChIP-sequencing datasets from BCa tumor samples and cell lines, and gene expression analysis by RT-qPCR and enhancer- reporter assays, we elucidated the molecular mechanism behind the clock and hormone regulation of KLF9. Lentiviral knockdown and overexpression of KLF9 in three distinct breast epithelial cell lines (MCF10A, MCF7 and MDA-MB-231) was generated to demonstrate the role of KLF9 in orthogonal assays on breast epithelial survival, proliferation, apoptosis, and migration.
Results: We determined that KLF9 is a direct GC receptor target in mammary epithelial cells, and that induction is likely mediated through coordinate transcriptional activation from multiple CORT-responsive enhancers in the KLF9 locus. More interestingly, rhythmic expression of KLF9 in MCF10A cells was abolished in the highly aggressive MDA-MB-231 line. In turn, forced expression of KLF9 altered the baseline and GC/E2-responsive expression of several clock genes, indicating that KLF9 may function as a regulator of the core clock machinery. Characterization of the role of KLF9 using complementary cancer hallmark assays in the context of the hormone-circadian axis revealed that KLF9 plays a tumor-suppressive role in BCa regardless of molecular subtype. KLF9 potentiated the anti-tumorigenic effects of CORT in ER+ luminal MCF7 cells, while it restrained CORT-enhanced oncogenicity in triple-negative MCF10A and MDA-MB-231 cells.
Conclusions: Taken together, our findings support that dysregulation of KLF9 expression and oscillation in BCa impinges on circadian network dynamics, thus ultimately affecting the BCa oncogenic landscape.
Investigating the factorial structure and measurement invariance of the parent-reported Strengths and Difficulties Questionnaire at 11 years old from the UK Millennium Cohort Study
Authors: Staatz Charis Bridger , Kelly Yvonne , Lacey Rebecca , Hardy Rebecca 
Published: November 2022

Abstract
Background: The strengths and difficulties questionnaire (SDQ) consist of five sub-scales that have been used to measure internalising and externalising symptoms in children, typically by combining sum scores of two sub-scales each. However, the different possible factorial structures that represent these symptoms have not been formally tested in a contemporary sample of UK children, while it is also necessary to consider whether the SDQ is interpreted similarly across subgroups of the population.
Methods: Exploratory and confirmatory factor analysis were used to test three competing structures for the parent-reported SDQ collected at age 11, the start of adolescence, in the UK Millennium Cohort Study (n=11,519), and measurement invariance was assessed for sex and area level deprivation. Internal consistency using ordinal alpha, internal convergent validity and external discriminant validity using average variance explained (AVE), and predictive validity were assessed.
Results: A five-factor model and a model with two second-order factors for internalising and externalising symptoms had better model fit than a three-factor model. For both of these structures, invariance was demonstrated across sex and area deprivation. AVE scores for the five-factor model indicated that peer and emotional problems factors were measuring a similar construct, as were the hyperactivity and conduct factors. In the second-order model, AVE scores indicated internalising and externalising symptoms were distinct constructs.
Conclusion: A second-order model with two factors for internalising and externalising symptoms is appropriate for use in a contemporary cohort of children and can be used in analysis investigating differences in symptoms across subgroups of the population.
A Prospective Study on Patterns and Management Outcomes of Intracranial Hematoma at Jimma University Medical Center
Authors: Simegnew Nebiyou ,   2.	Mohammed Abafita,   3.	Addis Temie Worku,   4.	Minale Fekadie Baye
Published: November 2022

Abstract

Background: Intracranial hematoma is the collection of blood in the various intracranial spaces. Knowledge of patterns, origins/causes, and outcomes of ICH conditions are important for decision-making for urgent surgical interventions such as craniotomy and hematoma evacuations. No prior study was conducted in our setup. This study aimed to assess patterns and management outcomes of intracranial hematoma in Jimma University Medical center.
Methods: An institution-based prospective cross-sectional study design was conducted in Jimma University Medical Center, Jimma, Ethiopia for 6 consecutive months from June to December 2020. The data were cleaned and entered to Epidata version 3.1 and then exported and analyzed using SPSS Version 24.
Results: A total of 91 neurosurgery eligible patients were recruited during the study period with a mean age of 34 years. The majority of neurosurgery patients were males 73 (80.2%) and more common in reproductive age groups (62.6%), from rural areas (50.5%). About 93.4% of patients reported a history of trauma and road traffic accidents & fighting account for 63.8% of the trauma cases. Sixty-five percent of patients arrive in the hospital within 24 hours. Upon presentation, loss of consciousness (48.4%), convulsion (11%), aspiration (9.9%) and increased ICP (12%). The majority (49.5%) of the patients had a mild head injury. The focal neurologic deficits were hemiparesis (29.7%) and hemiplegia (5.5%). Acute epidural hematoma (68.1%) was a common finding followed by sub-acute subdural hematoma. Of the total study participants, 11% of the patients were died. All the surviving patients were accessed after one month of discharge and re-assessed, 66 patients had good neurologic (62 upper and 4 lower good recovery), 11 patients had some disability (7 lower and 4 upper-moderate disabilities), two patients had a severe disability and two patients (those among severe disability) had died.
Conclusion: Trauma was invariably the cause of intracranial hematoma and patients with low GCS, papillary abnormality, aspiration, and increased ICP had increased risk of dying from their illness. It is good to formulate policy to enhance injury prevention and bring health-oriented behavioral change.
Identifikasi WIN1 (Wax Inducer1) Pada Tanaman Ubi Kayu (Manihot esculenta Crantz.)
Authors: Su'udi Mukhamad , Hasanah Lailiyah Maulidatul , Puspito Agung Nugroho , Arimurti Sattya 
Published: November 2022

Tanaman pangan di Indonesia sangat beragam termasuk diantaranya padi, jagung dan ubi kayu. Namun lahan pertanian di Indonesia semakin sempit seiring dengan laju pertumbuhan penduduk yang semakin tinggi. Lahan kering (sub optimal) di Indonesia masih banyak yang belum dimanfaatkan, yang sebenarnya bisa dioptimalkan sebagai lahan pertanian. Tanaman pangan yang memiliki tingkat ketahanan lebih tinggi terhadap lahan kering adalah tanaman ubi kayu, sehingga berpotensi untuk ditanam pada lahan kering. Tahap pertama pemuliaan tanaman ubi kayu adalah mengetahui karakterisasi gen pada tanaman tersebut salah satunya yaitu WIN1. Metode pertama yang dilakukan adalah isolasi DNA daun ubi kayu varietas Adira 1 dan Malang 6, kemudian amplifikasi dengan PCR, dan analisis sekuensing. Hasil menunjukkan tanaman ubi kayu Adira 1 memiliki asam amino yang sama dengan kultivar am560-2 yang terdapat pada GenBank, sedangkan pada varietas Malang 6 terdapat satu asam amino yang berbeda. Hal tersebut dapat dipengaruhi oleh adanya mutasi gen pada varietas ubi kayu serta perbedaan kandungan HCN pada ubi kayu pangan varietas Adira 1, dan ubi kayu industri varietas Malang 6.
Cytocidal activities of hiv-1 vpr are shared by primate lentivirus vpr and vpx relatives
Authors: Macreadie I. G. 
Published: November 2022

Abstract:
The ability of HIV-1 Vpr to kill human cells has been shown to be due to the sequence, HFRIGCRHSRIG, comprising Vpr amino acid residues 71-82. In this study cell killing by Vpr equivalents in other primate lentiviruses has been examined. Five purified synthetic peptides, related to the bioactive region ofHIV-1 Vpr and derived from HIV-2 Vpr and Vpx, SIVmac Vpr and Vpx, and SIVagm Vpx, were shown to share similar abilities to penetrate and kill cells.
Cytokine Rhgm-Csf Interaction with Peptide Fragment Of Hgm-Csf Receptor A-Chain Monitored By Nilia-Cd Spectroscopy
Authors: Siligardi Giuliano , Hussain Rohanah , Rovero Paolo , Galoppini Claudia 
Published: November 2022

Abstract:
Pl 15 a peptide fragment of hGM-CSFR a-chain was observed to interact selectively to cytokine rhGM-CSF (Kd=35µM) and not to IL-3 in solution by non-immobilised ligand interaction assay (NILIA) by CD spectroscopy in the spectral region characteristic ofTrp aromatic side-chain and disulphide bond chromophores (290-330mn). The information provided by NILIA-CD identified two continuous peptide fragments of GM­ CSF that could be used as a good candidate to bind to GM-CSF receptor a-chain. We propose this approach of combining spectroscopic and crystallographic information to guide the search for receptor ligand.
Human TNF Mutants with Selective Affinity on the R55 Or R75 Receptor
Authors: Xiaowei Zhou , Guoli Wang , Peitang Huang 
Published: November 2022

Abstract:
Four new-type TNF mutants, which discriminated between its two receptors R55 and R75, were designed based on the structural model of TNF-receptor complexes. All mutants were purified for competitive binding assay with 1251 wild-type hTNF to the recombinant hTNF-R55 and hTNF-R75 receptors. Two of the four mutants were found to selectively retain most of their binding capacity to one of the receptors, but decreased affinity to other one, significantly as designed.
An Analysis of the Main Causes of Delays in the Completion of Road Construction Projects: A Case Study of Tanzania
Authors: Kullaya Donati Michael , Alemu Muluken Kassahun , Yeom Chun Ho 
Published: November 2022

Introduction
Completing road construction projects in time is a challenge for developing countries, specifically for Tanzania, where great economic costs result from difficulties in identifying and reducing the factors that cause the delay.

Methods
This study addresses factors that cause the delay of a road construction project in Tanzania and proposes some methods that could potentially reduce this delay. A structured questionnaire was drawn up through an interactive online workshop with the help of experts and professionals from the road construction sector in Tanzania, and follow-up interviews were conducted.

Results and Discussion
In addition, the first results were analyzed, and the factors identified were combined into five important groups, namely, client-related, consultant-related, contractor-related, design-related, and external factors. These were the main contributing aspects to delays in road construction projects in Tanzania.

Conclusion
Furthermore, from across these groups, six significant causes of delays emerged, and these were inadequate access to finance and delayed payments for completed work, financial problems or difficulties, unwillingness or inability to sustain operations over long periods of non-payment, an unrealistic program of works (Works Schedule), inadequate site management, and political interference.
Parental Factors Associated With Internet Gaming Disorder Among First-Year High School Students: Longitudinal Study
Authors: She Rui , Zhang Youmin , Yang Xue 
Published: November 2022

Background
Parents play central roles in adolescents’ socialization, behavioral development, and health, including the development of internet gaming disorder (IGD). However, longitudinal research on the parental predictors of adolescent IGD is limited.

Objective
This study aimed to investigate the reciprocal associations between various parental factors and adolescent IGD using 2-wave cross-lagged models.

Methods
A sample of 1200 year-one high school students in central China completed a baseline assessment in 2018 (mean age 15.6 years; 633/1200, 52.8% male) and a follow-up survey in 2019. IGD was measured using the 9-item DSM-5 IGD Symptoms checklist. Perceptions related to parental variables, including psychological control, parental abuse, parental support, and the parent-child relationship, were also collected from the adolescents.

Results
Of all the participants, 12.4% (148/1200) and 11.7% (140/1200) were classified as having IGD at baseline (T1) and follow-up (T2), respectively. All 4 cross-lagged models fit the data well (range for the comparative fit index .91-.95; range for the standardized root mean square residual .05-.06). Parental support (β=–.06, P=.02) and parental abuse (β=.08, P=.002) at T1 predicted IGD symptoms at T2, while parental psychological control (β=.03, P=.25) and a positive relationship with parents (β=–.05, P=.07) at T1 had nonsignificant effects on IGD symptoms at T2, when controlling for background variables. In addition, IGD symptoms at T1 did not predict parental factors at T2.

Conclusions
The findings suggest that parental factors may be significant predictors of adolescent IGD. Health interventions should consider involving parents to increase the effectiveness of treatment to prevent and reduce adolescent IGD.