bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remarkable NH3 absorption in metal‐based deep eutectic solvents by multiple coordination and hydrogen‐bond interaction
Authors: Cheng Ning‐Ning , Li Zi‐Liang , Lan Hong‐Chao , Xu Wen‐Long , Huang Kuan 
Published: February 2022

AbstractThe elimination and recycling of NH3 from the vented circulating stream of NH3 synthesis process is of great significance to the protection of air environment and saving of NH3 product. Deep eutectic solvents (DESs) with as many weak acidic sites as possible are anticipated to exhibit high efficiency for NH3 absorption at low pressures. Herein, we designed and prepared a series of metal‐based DESs by mixing EaCl, metal chloride (SnCl2, ZnCl2, FeCl3, or CoCl2), and Gly. The physiochemical properties, NH3 absorption performance, and mechanism of prepared metal‐based DESs were investigated systematically. It is found that considerably high solubilities of NH3 in DESs can be achieved by utilizing the multiple coordination and hydrogen‐bond interaction with NH3 provided by metal ions and Gly respectively. The values of NH3 solubilities (17.55 mol/kg at 298.2 K and 103.0 kPa, and 10.24 mol/kg at 298.2 K and 6.8 kPa) are the highest reported to date.
Landscape genetics of the tropical willowSalix humboldtiana: influence of climate, salinity, and orography in an altitudinal gradient
Authors: Hernández‐Leal Mariana S. , Suárez‐Atilano Marco , Nicasio‐Arzeta Sergio , Piñero Daniel , González‐Rodríguez Antonio 
Published: February 2022

AbstractPremiseGene flow in riparian ecosystems is influenced by landscape features such as orography, climate, and salinity. The downstream increase in genetic diversity (DIGD) hypothesis states that the unidirectionality of the watercourse causes an accumulation of genetic diversity toward downstream populations, while upstream populations are more structured and less diverse, especially in water‐dispersed organisms.MethodsWe used chloroplast and nuclear microsatellites to characterize genetic diversity, structure, and gene flow patterns among populations ofSalix humboldtianaacross an elevation and salinity gradient on three rivers (Actopan, Antigua, and Blanco) in Mexico. We used optimization of resistance surface methods to determine whether genetic distances between populations are correlated with landscape features.ResultsPositiveFISvalues evidenced biparental inbreeding in some populations, particularly at higher elevations where lower niche availability constrains colonization and persistence. Four genetic groups were distinguished, corresponding to populations on the Actopan and Antigua rivers and upstream and downstream on the Blanco, but with high admixture between populations on the Actopan and Antigua rivers. Higher gene flow rates were found among proximate populations on the same river than among different rivers. Genetic diversity increased toward the river mouths, in support of the DIGD hypothesis, probably due to greater niche availability and larger population size. Differences among rivers in precipitation patterns and salinity, as well as geographic distance, were significant predictors of gene flow.ConclusionsOur results depict that the DIGD and gene flow patterns inS. humboldtianaresult from the complex interaction among physiography, climate, river salinity, and life‐history traits of the species.
Effects of snow on reproduction of perennial Thalictrum dioicum: Plants survive but seedlings fail to recruit with reduced snow cover
Authors: Ósvaldsson Anna , Chesler Maddelana K. , Burns Jean H. 
Published: February 2022

AbstractPremiseFuture reductions in snow cover are expected in temperate climates, likely leading to more soil‐freezing events and damage to plant tissues. However, whether and how plants can compensate for this damage may depend on the timing of damage and on plant allocations to seed size and number. We need more information about how seed production, germination, and seedling recruitment might respond to changes in snow cover.MethodsWe manipulated snow cover over three seasons in a common garden experiment with four treatments: (1) “control,” where snowpack was left unmanipulated throughout the winter season; (2) “late addition,” where snowpack was experimentally increased at the end of the winter season in order to delay the onset of spring; (3) “late removal,” where snowpack was experimentally reduced at the end of the winter season in order to advance the onset of spring; and (4) “freeze,” a consistent removal treatment, where snowpack was experimentally reduced following every substantial snowfall in order to induce freeze‐thaw events in the soil. In all treatments, we measured survival, growth, reproduction, and recruitment of a native perennial herb, Thalictrum dioicum.ResultsReduced snow cover minimally influenced adult survival. Instead, individuals that experienced reduced snow cover throughout the winter produced more massive seeds, whereas individuals that experienced a single snow removal at the end of the season produced less massive seeds. Seedling recruitment was lower in the removal treatments than in the control, as a result of failure to germinate in the freeze treatment and seedling mortality in the late removal treatment.ConclusionsBoth reduced snow cover throughout the winter and a single late snow removal in the spring reduced seedling recruitment, but for different reasons, suggesting that a holistic approach to the life cycle is needed to understand responses to shifting climates.
Alzheimer's disease research progress in the Mediterranean region: The Alzheimer's Association International Conference Satellite Symposium
Authors: Sexton Claire , Solis Michele , Aharon‐Peretz Judith , Alexopoulos Panagiotis , Apostolova Liana G. , Bayen Eléonore , Birkenhager Betty , Cappa Stefano , Constantinidou Fofi , Fortea Juan , Gerritsen Debby L. , Hassanin Hany I. , Ibanez Agustin , Ioannidis Panagiotis , Karageorgiou Elissaios , Korczyn Amos , Leroi Iracema , Lichtwarck Bjorn , Logroscino Giancarlo , Lynch Chris , Mecocci Patrizia , Molinuevo Jose Luis , Papatriantafyllou John , Papegeorgiou Sokratis , Politis Antonis , Raman Rema , Ritchie Karen , Sanchez‐Juan Pascual , Sano Mary , Scarmeas Nikolas , Spiru Luiza , Stathi Afroditi , Tsolaki Magda , Yener Görsev , Zaganas Ioannis , Zygouris Stelios , Carrillo Maria 
Published: February 2022

AbstractAs research and services in the Mediterranean region continue to increase, so do opportunities for global collaboration. To support such collaborations, the Alzheimer's Association was due to hold its seventh Alzheimer's Association International Conference Satellite Symposium in Athens, Greece in 2021. Due to the COVID‐19 pandemic, the meeting was held virtually, which enabled attendees from around the world to hear about research efforts in Greece and the surrounding Mediterranean countries. Research updates spanned understanding the biology of, treatments for, and care of people with Alzheimer's disease (AD_ and other dementias. Researchers in the Mediterranean region have outlined the local epidemiology of AD and dementia, and have identified regional populations that may expedite genetic studies. Development of biomarkers is expected to aid early and accurate diagnosis. Numerous efforts have been made to develop culturally specific interventions to both reduce risk of dementia, and to improve quality of life for people living with dementia.
Plasma amyloid beta predicts conversion to dementia in subjects with mild cognitive impairment: The BALTAZAR study
Authors: Hanon Olivier , Vidal Jean‐Sébastien , Lehmann Sylvain , Bombois Stéphanie , Allinquant Bernadette , Baret‐Rose Christiane , Tréluyer Jean‐Marc , Abdoul Hendy , Gelé Patrick , Delmaire Christine , Blanc Fredéric , Mangin Jean‐François , Buée Luc , Touchon Jacques , Hugon Jacques , Vellas Bruno , Galbrun Evelyne , Benetos Athanase , Berrut Gilles , Paillaud Elena , Wallon David , Castelnovo Giovanni , Volpe‐Gillot Lisette , Paccalin Marc , Robert Philippe , Godefroy Olivier , Camus Vincent , Belmin Joël , Vandel Pierre , Novella Jean‐Luc , Duron Emmanuelle , Rigaud Anne‐Sophie , Schraen‐Maschke Susanna , Gabelle Audrey ,   the BALTAZAR study group
Published: February 2022

AbstractIntroductionBlood‐based biomarkers are the next challenge for Alzheimer's disease (AD) diagnosis and prognosis.MethodsMild cognitive impairment (MCI) participants (N = 485) of the BALTAZAR study, a large‐scale longitudinal multicenter cohort, were followed‐up for 3 years. A total of 165 of them converted to dementia (95% AD). Associations of conversion and plasma amyloid beta (Aβ)1‐42, Aβ1‐40, Aβ1‐42/Aβ1‐40 ratio were analyzed with logistic and Cox models.ResultsConverters to dementia had lower level of plasma Aβ1‐42 (37.1 pg/mL [12.5] vs. 39.2 [11.1] , P value = .03) and lower Aβ1‐42/Aβ1‐40 ratio than non‐converters (0.148 [0.125] vs. 0.154 [0.076], P value = .02). MCI participants in the highest quartile of Aβ1‐42/Aβ1‐40 ratio (>0.169) had a significant lower risk of conversion (hazard ratio adjusted for age, sex, education, apolipoprotein E ε4, hippocampus atrophy = 0.52 (95% confidence interval [0.31–0.86], P value = .01).DiscussionIn this large cohort of MCI subjects we identified a threshold for plasma Aβ1‐42/Aβ1‐40 ratio that may detect patients with a low risk of conversion to dementia within 3 years.
Characterization of sodium carboxymethyl cellulose/calcium alginate scaffold loaded with curcumin in skin tissue engineering
Authors: Rezaei Mohadeseh , Hassanzadeh Nemati Nahid , Mehrabani Davood , Komeili Ali 
Published: February 2022

AbstractApplying biological macromolecule like curcumin (CUC) has gained considerable attention for the anti‐inflammatory, antioxidant, antimicrobial and antitumor properties. Therefore, this study was carried out to characterize carboxymethylcellulose/calcium alginate (CMC/CA) scaffold loaded with CUC in skin tissue engineering. To observe the structural, mechanical, degradability, biological and antibacterial effect of CUC, it was loaded in a cellulose‐based electrospinning scaffold of sodium CMC (SCMC) with CA. The addition of CUC increased the fiber diameter to 504 ± 83, and 522 ± 25 nm in 3% and 5% of CUC concentrations, respectively. The elasticity of the scaffold was enhanced, while the scaffold strength was decreased slightly. The inhibitory zone in the scaffold containing CUC denoted to its antibacterial properties. In addition, the cell viability, proliferation and attachment to the electrospun scaffolds were increased. Utilization of CUC‐loaded materials can play an important role in anti‐bacterial performance of the scaffold. Although mechanical properties of SCMC may slightly decreased during the loading process, but the morphological, chemical, and biological properties were improved. It seems that applying electrospinning technique and CUC incorporation in fabricated scaffolds can be a promising choice in skin tissue engineering when antibacterial properties are also targeted in conjunction with the tensile strength.
Transcriptome of miRNA during inhibition of Bombyx mori nuclear polyhedrosis virus by geldanamycin in BmN cells
Authors: Zhao Zhi‐meng , Yin Hao‐tong , Shen Man‐man , Zhang Shao‐lun , Chen Zi‐kang , Li Tao , Zhang Zhen‐dong , Zhao Wei‐guo , Guo Xi‐jie , Wu Ping 
Published: February 2022

AbstractBombyx mori nuclear polyhedrosis virus (BmNPV) is one of several viruses that cause great harm to the sericulture industry, and its pathogenic mechanism is still being explored. Geldanamycin (GA), a kind of HSP90 inhibitor, has been verified to suppress BmNPV proliferation. However, the molecular mechanism by which GA inhibits BmNPV is unclear. MicroRNAs (miRNAs) have been shown to play a key role in regulating virus proliferation and host‐pathogen interactions. In this study, BmN cells infected with BmNPV were treated by GA and DMSO for 72 h, respectively, then transcriptome analysis of miRNA was performed from the GA group and the control group. As a result, a total of 29 miRNAs were differentially expressed (DE), with 13 upregulated and 16 downregulated. Using bioinformatics analysis, it was found that the target genes of DEmiRNAs were involved in ubiquitin‐mediated proteolysis, phagosome, proteasome, endocytosis pathways, and so on. Six DEmiRNAs were verified by quantitative reverse‐transcription polymerase chain reaction. DElong noncoding RNA (DElncRNA)–DEmiRNA–messenger RNA (mRNA) regulatory networks involved in apoptosis and immune pathways were constructed in GA‐treated BmN cells, which included 12 DEmiRNA, 132 DElncRNA, and 69 mRNAs. This regulatory network enriched the functional role of miRNA in the BmNPV‐silkworm interactions and improved our understanding of the molecular mechanism of HSP90 inhibitors on BmNPV proliferation.
Recent Advances in Inorganic Electrochromic Materials from Synthesis to Applications: Critical Review on Functional Chemistry and Structure Engineering
Authors: Li Borui , Dang Jie , Zhuang Qianyu , Lv Zepeng 
Published: February 2022

AbstractFor the assembly of electrochromic devices (ECDs) with generally multilayer structures, supportive components usually are needed to be incorporated with EC materials. Herein, we reviewed several impressive methods to design and fabricate ECDs with high performance and versatility based on recent frontier research. The first part of the review is centered on the desirability and strengthening mechanism of nanostructured inorganic EC materials. The second part illustrates the recent advances in transparent conductors. We then summarize the demands and means to modify the formation of electrolytes for practicable ECDs. Moreover, efforts to increase the compatibility with the EC layer and ion capacity are delineated. At the end, the application prospects of inorganic ECDs are further explored, which offers a guideline for the industrialization process of ECDs.
SmI2‐mediated C‐alkylation of Ketones with Alcohols under Microwave Conditions: A Novel Route to Alkylated Ketones
Authors: Pawar Gaurav , Mahammad Ghouse Shaik , Kar Swayamsiddha , Manohar Chelli Sai , Reddy Dannarm Srinivas , Gour Jitendra , Sonti Rajesh , Nanduri Srinivas 
Published: February 2022

AbstractA novel protocol is developed towards the preparation of alkylated ketones from alcohols in presence of catalytic amount of SmI2 and base with the elimination of water as a single by‐product under microwave irradiation conditions. Furthermore, applicability of this methodology to the synthesis of Donepezil and late‐stage functionalization in Pregnenolone is also reported. Successful application of this methodology in Friedländer quinolone synthesis using 2‐aminobenzyl alcohol and various acetophenones expand the synthetic utility of this protocol.
Trapping a [W10O32]6− Decatungstate Anion in an Ag44 Nanowheel
Authors: Yu Jia‐Qun , Xue Chun‐Hui , Zhou Kun , Fang Yuan , Ji Jiu‐Yu , Chen Bao‐Kuan , Bi Yan‐Feng 
Published: February 2022

AbstractCompound [Ag44(W10O32)(StBu)24(CF3COO)8](CF3COO)6 ⋅ 6H2O (1) was synthesized through a one‐pot method. This is the first case of isolating a new silver thiolate cluster containing a [W10O32]6− template which transforms from WO42− polyoxoanion through a self‐assembly process. The anionic nature of the reduced [W10O32]6− template and the effective silver‐oxygen interaction contribute to the formation of the Ag44 nanowheel in 1. The luminescence, photocatalytic activity and electrochemistry properties of 1 were studied.
Systematic analysis of chemical profiles of Sophorae tonkinensis Radix et Rhizoma in vitro and in vivo using UPLC‐Q‐TOF‐MSE
Authors: Yuan Wen‐lin , Huang Zheng‐rui , Xiao Si‐jia , Zhang Yu‐hao , Chen Wei , Ye Ji , Xu Xi‐ke , Zu Xian‐peng , Shen Yun‐heng 
Published: February 2022

AbstractSophorae tonkinensis Radix et Rhizoma (S. tonkinensis) has been recorded as a ‘poisonous’ Chinese herbal medicine in Chinese Pharmacopoeia 2020. The clinical reaction reports of S. tonkinensis indicated its neurotoxicity; however, there still exists dispute about its toxic substances. At present, no report is available on the blood and brain prototype research of S. tonkinensis. Most studies focused on alkaloids and less on other compounds. Moreover, the constituents absorbed into the blood and brain have been rarely investigated so far. This study established a rapid and efficient qualitative analysis method using UPLC‐Q‐TOF‐MSE to characterize the ingredients of S. tonkinensis and those entering into the rat's body after oral administration. A total of 91 compounds were identified in S. tonkinensis, of which 28 were confirmed by the standards. In addition, 30 and 19 prototypes were also first identified in the rat's blood and brain, respectively. It was found that most flavonoids, except alkaloids, were detected in the rat's body and distributed in the cerebrospinal fluid, suggesting that flavonoids may be one of the important toxic or effective substances of S. tonkinensis. This finding provides new clues and data for clarifying the toxicity or efficacy of this medicinal plant.
Prediction of lung metastases in thyroid cancer using machine learning based on SEER database
Authors: Liu Wenfei , Wang Shoufei , Ye Ziheng , Xu Peipei , Xia Xiaotian , Guo Minggao 
Published: February 2022

AbstractPurposeLung metastasis (LM) is one of the most frequent distant metastases of thyroid cancer (TC). This study aimed to develop a machine learning algorithm model to predict lung metastasis of thyroid cancer for providing relative information in clinical decision‐making.MethodsData comprising of demographic and clinicopathological characteristics of patients with thyroid cancer were extracted from the National Institutes of Health (NIH)’s Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015, which is employed to develop six machine learning algorithm models support vector machine (SVM), logistic regression (LR), eXtreme gradient boosting (XGBoost), decision tree (DT), random forest (RF), and k‐nearest neighbor (KNN). Compared and evaluated models by the following indicators: accuracy, precision, recall rate, F1‐score, the area under the ROC curve (AUC) value and Brier score, and interpreted the association between clinicopathological characteristics and target variables based on the best model.ResultsNine thousand nine hundred and fifty patients were selected, which including 212 patients (2.1%) with lung metastasis, and 9738 patients without lung metastasis (97.9%). Multivariate logistic regression showed that age, T stage, N stage, and histological type were independent factors in TC with LM. Evaluation indicators of the best model‐ RF were as following: accuracy (0.99), recall rate (0.88), precision (0.61), F1‐score (0.72), AUC value (0.99), and the Brier score (0.016).ConclusionRF learning model performed better and can be applied to forecast lung metastasis of thyroid cancer, and offer valuable and significant reference for clinicians' decision‐making in advance.
Single Atoms Anchored in Hexagonal Boron Nitride for Propane Dehydrogenation from First Principles
Authors: Xiong Chuanye , Dai Sheng , Wu Zili , Jiang De‐en 
Published: February 2022

AbstractSingle‐atom catalysts embedded in N‐doped graphene have attracted great interest recently, but the hexagonal boron nitride (h‐BN) is much less explored as a support. Using first principles density function theory and molecular dynamics, here we investigate the stability of Pt, Au, and Ru single atoms anchored at B and N vacancies on h‐BN. We find that Pt and Ru single atoms are much more stable than Au on h‐BN. We further examine propane dehydrogenation on these single‐atom catalysts and find that Pt1 at the B vacancy in h‐BN and Ru1 at the N vacancy in h‐BN show excellent activity for propane dehydrogenation, as evidenced by low energy barriers for both dehydrogenation steps. Our work suggests that Pt and Ru single atoms anchored at vacancy sites in h‐BN could be promising for propane dehydrogenation.
The Crucial Role of Bioenergy in a Climate‐Neutral Energy System in Germany
Authors: Lauer Markus , Dotzauer Martin , Millinger Markus , Oehmichen Katja , Jordan Matthias , Kalcher Jasmin , Majer Stefan , Thraen Daniela 
Published: February 2022

AbstractGreenhous gas mitigation requires urgent action, especially in transforming the energy system. Bioenergy is expected to counterbalance the variable power from wind and solar energy, but also for the de‐fossilization of the heat and transport sectors. This study assesses the wide range of options and evaluates the most cost‐efficient allocation of biomass for 95 % greenhouse gas emission reduction in the German energy system till 2050. The final state in 2050 shows bioenergy in different sectors, including pellet and woodchip boilers, bio‐based methane, different combined heat and power concepts, as well as liquid fuels, such as synthetic kerosene. Lignocellulosic biomass makes up the major proportion of future biomass options; however, appropriate strategies are needed to mobilize it.
A Review of Biomass Resources and Thermochemical Conversion Technologies
Authors: Jha Shivangi , Okolie Jude A. , Nanda Sonil , Dalai Ajay K. 
Published: February 2022

AbstractWaste biomass has the potential to produce renewable fuels and fine chemicals. Biofuels derived from agricultural, forestry, and energy crop systems are promising resources to address climate change and minimize greenhouse gas emissions. The recent advances in various thermochemical technologies for the conversion of waste biomass to value‐added biofuel products are discussed. A summarized outline of thermochemical technologies such as torrefaction, liquefaction, pyrolysis, and gasification is provided. An overview of different types and sources of biomass as well as their physicochemical properties is presented. The thermochemical conversion products and their environmental benefits are considered as well.
Modification of Biphenolic Anti‐Bacterial to Achieve Broad‐Spectrum Activity
Authors: Ochoa Cristian , Roenfanz Hanna F. , Kozlowski Marisa C. 
Published: February 2022

AbstractThe Gram‐positive bacteria, methicillin‐resistant Staphylococcus aureus (MRSA) and Gram‐negative bacteria, Acinetobacter baumannii, are pathogens responsible for millions of nosocomial infections worldwide. Due to the threat of bacteria evolving resistance to antibiotics, scientists are constantly looking for new classes of compounds to treat infectious diseases. The biphenolic analogs of honokiol that were most potent against oral bacteria had similar bioactivity against MRSA. However, all the compounds proved ineffective against A. baumannii. The inability to inhibit A. baumannii is due to the difficult‐to‐penetrate lipopolysaccharide‐coated outer membrane that makes it challenging for antibiotics to enter Gram‐negative bacteria. The C 2 scaffold was optimized from the inhibition of Gram‐positive bacteria to broad‐spectrum antibacterial compounds that inhibit the dangerous Gram‐negative pathogen A. baumannii.