bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of employment for adults with intellectual and developmental disabilities participating in a postsecondary transition program in the United States
Authors: Barnard‐Brak Lucy , Richman David M. , Mutua Kagendo , Williamson Amy 
Published: October 2022

AbstractBackgroundPrevious research has shown that post‐secondary collegiate vocational educational programs often have positive effects on employment outcomes for young adults with intellectual and developmental disabilities.AimsUsing secondary data of a program in the United States collected over several years, we examined which intervention components of a postsecondary education transition program predicted subsequent employment for young adults with intellectual and developmental disabilities.Materials & MethodsThe sample consisted of 56 individuals that participated in a transition‐services collegiate program; Crossing Points, University of Alabama.ResultsResults were able to robustly indicate that acquiring job‐specific skills was a much better predictor than global measures of intellectual or adaptive behaviour. Additionally, survival curve analyses as an innovative approach to this population showed that there was a positive relation between the number of job‐specific training sessions and eventual community employment.DiscussionResults are discussed in relation to a historical parallel movement to expand inclusion of students with intellectual and developmental disabilities in the least restrictive educational setting for primary and secondary public education years.ConclusionIn conclusion, the results of the current study suggest positive findings with job‐skills training both specific and general.
Standardized home blood pressure monitoring: Rationale behind the 722 protocol
Authors: Lin Hung‐Ju , Pan Heng‐Yu , Chen Chen‐Huan , Cheng Hao‐Min , Chia Yook‐Chin , Sogunuru Guru Prasad , Tay Jam Chin , Turana Yuda , Verma Narsingh , Kario Kazuomi , Wang Tzung‐Dau 
Published: October 2022

AbstractHome blood pressure (HBP) has been recognized as a prognostic predictor for cardiovascular events, and integrated into the diagnosis and management of hypertension. With increasing accessibility of oscillometric blood pressure devices, HBP monitoring is easy to perform, more likely to obtain reliable estimation of blood pressures, and feasible to document long‐term blood pressure variations, compared to office and ambulatory blood pressures. To obtain reliable HBP estimates, a standardized HBP monitoring protocol is essential. A consensus regarding the optimal duration and frequency of HBP monitoring is yet to be established. Based on the current evidence, the “722” protocol, which stands for two measurements on one occasion, two occasions a day (morning and evening), and over a consecutive of 7 days, is most commonly used in clinical studies and recommended in relevant guidelines and consensus documents. HBP monitoring based on the “722” protocol fulfills the minimal requirement of blood pressure measurements to achieve agreement of blood pressure classifications defined by office blood pressures and to predict cardiovascular risks. In the Taiwan HBP consensus, the frequency of repeating the “722” protocol of HBP monitoring according to different scenarios of hypertension management, from every 2 weeks to 3 months, is recommended. It is reasonable to conclude that the “722” protocol for HBP monitoring is clinically justified and can serve as a basis for standardized HBP monitoring.
Neurodegenerative diseases and blood pressure variability: A comprehensive review from HOPE Asia
Authors: Turana Yuda , Shen Robert , Nathaniel Michael , Chia Yook‐Chin , Li Yan , Kario Kazuomi 
Published: October 2022

AbstractAsia has an enormous number of older people and is the primary contributor to the rise in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. The therapy of many neurodegenerative diseases has not yet progressed to the point where it is possible to alter the course of the disease. Mid‐life hypertension is an important predictor of later‐life cognitive impairment and brain neurodegenerative conditions. These findings highlight the pivotal role of preventing and managing hypertension as a risk factor for neurodegenerative disease. Autonomic dysfunction, neuropsychiatric and sleep disturbances can arise in neurodegenerative diseases, resulting in blood pressure variability (BPV). The BPV itself can worsen the progression of the disease. In older people with neurodegenerative disease and hypertension, it is critical to consider 24‐h blood pressure monitoring and personalized blood pressure therapy.
Oxidative stability of Moringa oleifera seed oil: Effect of degumming and deodorization on tocopherol retention
Authors: Sukarno Wahyu Budi , Widigdo Iman , Christianti Isti , Wassell Paul 
Published: October 2022

AbstractMoringa oleifera seed oil (MSO) from Lombok was extracted by n‐hexane and evaluated after refining by several degumming methods to understand the impact of individual tocopherol retention and compared to extra virgin olive oil (EVOO) and high oleic palm oil (HOPO). MSO achieved an Oxidative Stability Index (15.8 h); EVOO (11.7 h) HOPO (8.83 h), based on two factors; the degree of unsaturation and total tocopherols, which did not accurately correlate with oxidation stability. The presence of tocopherol type affected the efficiency of heat stability in MSO, which is caused by a significant level of δ‐tocopherol (13.5 ppm), which was retained, through effective water degumming. Whereas, δ‐tocopherol in EVOO was not detected. This strongly suggests δ‐tocopherol contributes effectively against heat oxidation and thereby improved the overall stability of MSO.Novelty impact statementSeveral novelties are identified in this work, which at the time, could not be found within the literature: first, the type of phosphatide in Moringa Oleifera is in hydratable form. Hence, secondly, we propose the appropriate degumming method for Moringa Oleifera seed oil is by water degumming. And third, the particular tocopherol type most impacting the oxidative stability performance of Moringa Oleifera was identified as δ‐tocopherol.
Assessing the wellbeing of family caregivers of multimorbid and homebound older adults—A scoping literature review
Authors: Robertson Mariah L. , Phung Annie , Bhatnagar Shivani , Li Lingsheng , Schuchman Mattan , Wolff Jennifer , Ritchie Christine , Leff Bruce , Sheehan Orla C. 
Published: October 2022

AbstractBackgroundThe prevalence of homebound older adults in the United States more than doubled during the COVID‐19 pandemic with greater burden on family caregivers. Higher caregiver burden, more specifically higher treatment burden, contributes to increased rates of nursing home placement. There exist a multitude of tools to measure caregiver well‐being and they vary substantially in their focus. Our primary aim was to perform a scoping literature review to identify tools used to assess the facets of caregiver well‐being experienced by caregivers of persons with multiple chronic conditions (MCC) with a special focus on those caregivers of homebound adult patients.MethodsThe search was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) extension for scoping reviews. After refining search terms, searches were performed of the peer‐reviewed and gray literature.ResultsAfter removal of duplicate studies, a total of 5534 total articles were screened for relevance to our study. After all screening and review were completed, 377 total articles remained for full review which included 118 different quantitative tools and 20 different qualitative tools. We identified the 15 most commonly utilized tools in patients with MCC. The Zarit Burden Interview was the most commonly used tool across all of the studies. Of the 377 total studies, only eight of them focused on the homebound population and included 13 total tools.ConclusionsBuilding on prior categorization of well‐being tools, our work has identified several tools that can be used to measure caregiver well‐being with a specific focus on those caregivers providing support to older adults with MCC. Most importantly, we have identified tools that can be used to measure caregiver well‐being of family caregivers providing support to homebound older adults, an ever‐growing population who are high cost and high utilizers of health care services.
Income disclosure and consumer judgment in a multilevel marketing experiment
Authors: Miller Austin M. , Snyder Samantha , Bosley Stacie A. , Greenman Sarah 
Published: October 2022

AbstractConsumer protection concerns have been raised related to income misrepresentation in multilevel marketing (MLM) recruitment. Though not required by law, some MLM firms choose to voluntarily disclose income information about previous participants. Through replication and extension of the experiment created in Bosley, Greenman, and Snyder (2020), we investigate the impact of these disclosures on consumer interest and earnings expectations. We test the external validity of their findings with subjects from Mechanical Turk and explore issues regarding treatment heterogeneity and better‐than‐average bias. Supporting prior findings, we present evidence that income disclosures, on average, do not significantly affect subjects' interest in the MLM opportunity, but they do decrease earnings estimates for most while increasing earnings estimates for a few. These effects depend on a subject's numeracy skills and whether they see their earnings potential as better‐than‐average. We also find that asking about earnings estimates first tends to decrease interest.
Genetic and molecular architecture of familial hypercholesterolemia
Authors: Abifadel Marianne , Boileau Catherine 
Published: October 2022

AbstractAtherosclerotic cardiovascular disease is the leading cause of death globally. Despite its important risk of premature atherosclerosis and cardiovascular disease, familial hypercholesterolemia (FH) is still largely underdiagnosed worldwide. It is one of the most frequently inherited diseases due to mutations, for autosomal dominant forms, in either of the LDLR, APOB, and PCSK9 genes or possibly a few mutations in the APOE gene and, for the rare autosomal forms, in the LDLRAP1 gene. The discovery of the genes implicated in the disease has largely helped to improve the diagnosis and treatment of FH from the LDLR by Brown and Goldstein, as well as the introduction of statins, to PCSK9 discovery in FH by Abifadel et al., and the very rapid availability of PCSK9 inhibitors. In the last two decades, major progress has been made in clinical and genetic diagnostic tools and the therapeutic arsenal against FH. Improving prevention, diagnosis, and treatment and making them more accessible to all patients will help reduce the lifelong burden of the disease.
The double‐edged sword of CEO narcissism: A meta‐analysis of innovation and firm performance implications
Authors: Kraft Priscilla S. 
Published: October 2022

AbstractDespite a growing body of research, the role of chief executive officer (CEO) narcissism for firm performance is subject to a controversial discussion in the literature. To help advance the discussion, I build on upper echelon theory to propose that innovation is a crucial mediating mechanism that helps explain how CEO narcissism may be beneficial for firm performance. To better understand the conditions under which CEO narcissism may be beneficial for innovation and ultimately firm performance, I investigate the moderating role of CEO gender and managerial discretion. Building on 68 studies, results from meta‐analytical structural equation modeling confirm that CEO narcissism can be beneficial for firm performance through stimulating innovation. However, the results further caution that these performance benefits are likely to be canceled out by other detrimental actions pursued by narcissistic CEOs, indicating that they can be a double‐edged sword for firms. Moreover, the results support that narcissistic female CEOs engage less in innovation (compared to their male counterparts). Interestingly, they seem to engage in other beneficial actions which ultimately improve overall firm performance, whereas their male counterparts engage in other harmful actions which hurt overall firm performance. The results further highlight that, while the upsides of narcissistic CEOs for performance through innovation increase in high managerial discretion contexts, their greater leeway enhances their downsides even more, so that they do not only offset the benefits of narcissistic CEOs, but even lead to detrimental effects for performance. This study contributes to the literature on CEO narcissism by theorizing and empirically demonstrating that the relationship between CEO narcissism and performance is more complex than previously depicted and requires a more nuanced investigation of the underlying mechanism as well as of potential contingencies. Building on these findings, future research opportunities are identified to further advance the literature on CEO narcissism.
Securing wider EU commitment to the elimination of hepatitis C virus
Authors: Wedemeyer Heiner , Tergast Tammo L. , Lazarus Jeffrey V. , Razavi Homie , Bakoyannis Kostas , Baptista‐Leite Ricardo , Bartoli Marco , Bruggmann Philip , Buşoi Cristian‐Silviu , Buti Maria , Carballo Manuel , Castera Laurent , Colombo Massimo , Coutinho Rodrigo Sousa , Dadon Yuval , Esmat Gamal , Esteban Rafael , Farran Joan Colom , Gillyon‐Powell Mark , Goldberg David , Hutchinson Sharon , Janssen Harry L. A. , Kalamitsis George , Kondili Loreta A. , Lambert John S. , Marinho Rui Tato , Maticic Mojca , Patricello Aldo , Peck‐Radosavljevic Markus , Pol Stanislas , Poljak Mario , Pop Cora , Sokol Tomislov , Sypsa Vana , Tözün Nurdan , Younossi Zobair , Aghemo Alessio , Papatheodoridis George V. , Hatzakis Angelos 
Published: October 2022

AbstractIn 2016, the Hepatitis B and C Public Policy Association (HepBCPPA), gathered all the main stakeholders in the field of hepatitis C virus (HCV) to launch the now landmark HCV Elimination Manifesto, calling for the elimination of HCV in the EU by 2030. Since then, many European countries have made progress towards HCV elimination. Multiple programmes—from the municipality level to the EU level—were launched, resulting in an overall decrease in viremic HCV infections and liver‐related mortality. However, as of 2021, most countries are not on track to reach the 2030 HCV elimination targets set by the WHO. Moreover, the COVID‐19 pandemic has resulted in a decrease in HCV diagnoses and fewer direct‐acting antiviral treatment initiations in 2020. Diagnostic and therapeutic tools to easily diagnose and treat chronic HCV infection are now well established. Treating all patients with chronic HCV infection is more cost‐saving than treating and caring for patients with liver‐related complications, decompensated cirrhosis or hepatocellular carcinoma. It is more important than ever to reinforce and scale‐up action towards HCV elimination. Yet, efforts urgently need the dedicated commitment of policymakers at all governmental and policy levels. Therefore, the third EU Policy Summit, held in March 2021, featured EU parliamentarians and other key decision makers to promote dialogue and take strides towards securing wider EU commitment to advance and achieve HCV elimination by 2030. We have summarized the key action points and reported the ‘Call‐to‐Action’ statement supported by all the major relevant European associations in the field.
Evaluating the persistence and utility of five wild Vitis species in the context of climate change
Authors: Aguirre‐Liguori Jonas A. , Morales‐Cruz Abraham , Gaut Brandon S. 
Published: October 2022

AbstractCrop wild relatives (CWRs) have the capacity to contribute novel traits to agriculture. Given climate change, these contributions may be especially vital for the persistence of perennial crops, because perennials are often clonally propagated and consequently do not evolve rapidly. By studying the landscape genomics of samples from five Vitis CWRs (V. arizonica, V. mustangensis, V. riparia, V. berlandieri and V. girdiana) in the context of projected climate change, we addressed two goals. The first was to assess the relative potential of different CWR accessions to persist in the face of climate change. By integrating species distribution models with adaptive genetic variation, additional genetic features such as genomic load and a phenotype (resistance to Pierce's Disease), we predicted that accessions from one species (V. mustangensis) are particularly well‐suited to persist in future climates. The second goal was to identify which CWR accessions may contribute to bioclimatic adaptation for grapevine (V. vinifera) cultivation. To do so, we evaluated whether CWR accessions have the allelic capacity to persist if moved to locations where grapevines are cultivated in the United States. We identified six candidates from V. mustangensis and hypothesized that they may prove useful for contributing alleles that can mitigate climate impacts on viticulture. By identifying candidate germplasm, this study takes a conceptual step toward assessing the genomic and bioclimatic characteristics of CWRs.
RNA‐seq profiling reveals different pathways between remodeled vessels and myocardium in hypertrophic cardiomyopathy
Authors: Pisano Annalinda , Pera Loredana Le , Carletti Raffaella , Cerbelli Bruna , Pignataro Maria G. , Pernazza Angelina , Ferre Fabrizio , Lombardi Maria , Lazzeroni Davide , Olivotto Iacopo , Rimoldi Ornella E. , Foglieni Chiara , Camici Paolo G. , d'Amati Giulia 
Published: October 2022

AbstractObjectiveCoronary microvascular dysfunction (CMD) is a key pathophysiological feature of hypertrophic cardiomyopathy (HCM), contributing to myocardial ischemia and representing a critical determinant of patients' adverse outcome. The molecular mechanisms underlying the morphological and functional changes of CMD are still unknown. Aim of this study was to obtain insights on the molecular pathways associated with microvessel remodeling in HCM.MethodsInterventricular septum myectomies from patients with obstructive HCM (n = 20) and donors' hearts (CTRL, discarded for technical reasons, n = 7) were collected. Remodeled intramyocardial arterioles and cardiomyocytes were microdissected by laser capture and next‐generation sequencing was used to delineate the transcriptome profile.ResultsWe identified 720 exclusive differentially expressed genes (DEGs) in cardiomyocytes and 1315 exclusive DEGs in remodeled arterioles of HCM. Performing gene ontology and pathway enrichment analyses, we identified selectively altered pathways between remodeled arterioles and cardiomyocytes in HCM patients and controls.ConclusionsWe demonstrate the existence of distinctive pathways between remodeled arterioles and cardiomyocytes in HCM patients and controls at the transcriptome level.
Evolution of p‐coumaroylated lignin in eudicots provides new tools for cell wall engineering
Authors: Mottiar Yaseen , Smith Rebecca A. , Karlen Steven D. , Ralph John , Mansfield Shawn D. 
Published: October 2022

Summary

Ester‐linked p‐coumarate (pCA) is a hallmark feature of the secondary cell walls in commelinid monocot plants. It has been shown that pCA groups arise during lignin polymerisation from the participation of monolignol conjugates assembled by p‐coumaroyl‐CoA:monolignol transferase (PMT) enzymes, members of the BAHD superfamily of acyltransferases.

Herein, we report that a eudicot species, kenaf (Hibiscus cannabinus), naturally contains p‐coumaroylated lignin in the core tissues of the stems but not in the bast fibres. Moreover, we identified a novel acyltransferase, HcPMT, that shares <30% amino acid identity with known monocot PMT sequences.

Recombinant HcPMT showed a preference in enzyme assays for p‐coumaroyl‐CoA and benzoyl‐CoA as acyl donor substrates and sinapyl alcohol as an acyl acceptor. Heterologous expression of HcPMT in hybrid poplar trees led to the incorporation of pCA in lignin, but no improvement in the saccharification potential of the wood.

This work illustrates the value in mining diverse plant taxa for new monolignol acyltransferases. Furthermore, the occurrence of pCA outside monocot lineages may represent another example of convergent evolution in lignin structure. This discovery expands textbook views on cell wall biochemistry and provides a new molecular tool for engineering the lignin of biomass feedstock plants.
A Novel Technique for the Treatment of Inferior Pole Fractures of the Patella: A Preliminary Report
Authors: Gao Zhixiang , Long Nengji , Yao Kai , Cai Peng , Dai Yixin , Yu Wei , Xiao Cong 
Published: October 2022

ObjectiveMost inferior pole fractures of the patella are comminuted. Therefore, an ideal treatment method has not been determined. We have presented a modified tension band fixation technique—the Krachow suturing, Nice knot combined with tension band fixation—and reported the results of the procedure.MethodsA total of 16 inferior patellar pole fractures were treated at our institution between January 2019 and October 2020, 15 of which underwent treatment with the modified tension band fixation technique consisting of Krachow suturing with Nice knots combined with tension band fixation. The primary measures: knee motion, Bostman score, anterior knee pain, fixation failure.ResultsBone union occurred at a mean of 9 weeks postoperatively (range: 8–13). There were no cases of postoperative anterior knee pain, refracture of the inferior patellar pole or wire breakage. The patients regained full ROM of the knee joint without functional deficits during follow‐up; the mean ROM was 128.46° ± 7.07° (range: 113.4°–137.8°). At the last follow‐up, all patients had a mean Bostman score of 28.40 ± 1.29 (range: 26–30), with an excellent score in 11 patients and a good score in four patients.ConclusionThe modified tension band fixation technique for the treatment of inferior patellar pole fractures is a simple and easy‐to‐perform surgical technique that provides stable fixation and good functional results.
Time‐ordering japonica/geng genomes analysis indicates the importance of large structural variants in rice breeding
Authors: Wang Yu , Li Fengcheng , Zhang Fan , Wu Lian , Xu Na , Sun Qi , Chen Hao , Yu Zhiwen , Lu Jiahao , Jiang Kai , Wang Xiaoche , Wen Siyu , Zhou Yao , Zhao Hui , Jiang Qian , Wang Jiahong , Jia Ruizong , Sun Jian , Tang Liang , Xu Hai , Hu Wei , Xu Zhengjin , Chen Wenfu , Guo Anping , Xu Quan 
Published: October 2022

SummaryTemperate japonica/geng (GJ) rice yield has significantly improved due to intensive breeding efforts, dramatically enhancing global food security. However, little is known about the underlying genomic structural variations (SVs) responsible for this improvement. We compared 58 long‐read assemblies comprising cultivated and wild rice species in the present study, revealing 156 319 SVs. The phylogenomic analysis based on the SV dataset detected the putatively selected region of GJ sub‐populations. A significant portion of the detected SVs overlapped with genic regions were found to influence the expression of involved genes inside GJ assemblies. Integrating the SVs and causal genetic variants underlying agronomic traits into the analysis enables the precise identification of breeding signatures resulting from complex breeding histories aimed at stress tolerance, yield potential and quality improvement. Further, the results demonstrated genomic and genetic evidence that the SV in the promoter of LTG1 is accounting for chilling sensitivity, and the increased copy numbers of GNP1 were associated with positive effects on grain number. In summary, the current study provides genomic resources for retracing the properties of SVs‐shaped agronomic traits during previous breeding procedures, which will assist future genetic, genomic and breeding research on rice.