bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of transcendental Hénon maps-II
Authors: Arosio Leandro , Benini Anna Miriam , Fornæss John Erik , Peters Han 
Published: February 2022

AbstractTranscendental Hénon maps are the natural extensions of the well investigated complex polynomial Hénon maps to the much larger class of holomorphic automorphisms. We prove here that transcendental Hénon maps always have non-trivial dynamical behavior, namely that they always admit both periodic and escaping orbits, and that their Julia sets are non-empty and perfect.
CT measures of femoral and tibial version and rotational position of femoral and tibial components of knee replacements: limitations in reliability and suitability for routine clinical practice
Authors: Toms Andoni P. , Rifai Tamam , Whitehouse Celia , McNamara Iain 
Published: February 2022

Abstract

Objectives
Rotational malalignment of knee replacements as measured on CT is understood to be associated with poor outcomes. The aim of this study is to measure the inter-rater and intra-rater reliability of measures of femoral and tibial version in the native arthritic knee and postoperative TKR component position using CT.

Methods
Eighty patients underwent CT of the knee before and after total knee replacement. Preoperative femoral and tibial version and component rotation were independently measured by two musculoskeletal radiologists.

Results
Mean differences between and within raters were small (< 1.6°). Maximum 95% limits of agreement for inter-rater and intra-rater comparisons were 8.1° and 7.6° for preoperative femoral version, 9.0° and 7.9° for postoperative femoral rotation, 26.0° and 20.5° for preoperative tibial version, and 24.9° and 23.6° for postoperative tibial rotation respectively. Postoperative ICCs varied from 0.68 to 0.81 (lower 95% CI:0.55–0.72) for both intra- and inter-rater comparisons. Preoperative ICCs were lower: 0.55–0.75 (lower 95% CI:0.40–0.65).

Conclusion
The lower 95% confidence level for ICC of version and rotational measurements using the Berger protocol of TKRs on CT are all less than 0.73 and that the normal range of differences between observers is up to 9° for the femoral component and 26° for the tibial component. This suggests that CT measurements derived from the Berger protocol may not be consistent enough for clinical practice.

Key Points
• CT is commonly used to measure the rotational profile of knee replacements in symptomatic patients using the Berger protocol.
• The limits of agreement for both femoral and tibial component rotation are wide even for experienced observers.
• CT measurements of the rotation of knee arthroplasty are not reliable enough for routine clinical use.
Protein tau concentration in blood increases after SCUBA diving: an observational study
Authors: Rosén Anders , Gennser Mikael , Oscarsson Nicklas , Kvarnström Andreas , Sandström Göran , Seeman-Lodding Helen , Simrén Joel , Zetterberg Henrik 
Published: February 2022

Abstract
Purpose
It is speculated that diving might be harmful to the nervous system. The aim of this study was to determine if established markers of neuronal injury were increased in the blood after diving.

Methods
Thirty-two divers performed two identical dives, 48 h apart, in a water-filled hyperbaric chamber pressurized to an equivalent of 42 m of sea water for 10 min. After one of the two dives, normobaric oxygen was breathed for 30 min, with air breathed after the other. Blood samples were obtained before and at 30–45 and 120 min after diving. Concentrations of glial fibrillary acidic, neurofilament light, and tau proteins were measured using single molecule array technology. Doppler ultrasound was used to detect venous gas emboli.

Results
Tau was significantly increased at 30–45 min after the second dive (p < 0.0098) and at 120 min after both dives (p < 0.0008/p < 0.0041). Comparison of matching samples showed that oxygen breathing after diving did not influence tau results. There was no correlation between tau concentrations and the presence of venous gas emboli. Glial fibrillary acidic protein was decreased 30–45 min after the first dive but at no other point. Neurofilament light concentrations did not change.

Conclusions
Tau seems to be a promising marker of dive-related neuronal stress, which is independent of the presence of venous gas emboli. Future studies could validate these results and determine if there is a quantitative relationship between dive exposure and change in tau blood concentration.
Patterns and roles of lignan and terpenoid accumulation in the reaction zone compartmentalizing pathogen-infected heartwood of Norway spruce
Authors: Nagy Nina Elisabeth , Norli Hans Ragnar , Fongen Monica , Østby Runa Berg , Heldal Inger M. , Davik Jahn , Hietala Ari M. 
Published: February 2022

Abstract
Main conclusion
Lignan impregnation of the reaction zone wood protects against oxidative degradation by fungi. Traumatic resin canals may play roles in the underlying signal transduction, synthesis, and translocation of defense compounds.

Abstract
Tree defense against xylem pathogens involves both constitutive and induced phenylpropanoids and terpenoids. The induced defenses include compartmentalization of compromised wood with a reaction zone (RZ) characterized by polyphenol deposition, whereas the role of terpenoids has remained poorly understood. To further elucidate the tree–pathogen interaction, we profiled spatial patterns in lignan (low-molecular-weight polyphenols) and terpenoid content in Norway spruce (Picea abies) trees showing heartwood colonization by the pathogenic white-rot fungus Heterobasidion parviporum. There was pronounced variation in the amount and composition of lignans between different xylem tissue zones of diseased and healthy trees. Intact RZ at basal stem regions, where colonization is the oldest, showed the highest level and diversity of these compounds. The antioxidant properties of lignans obviously hinder oxidative degradation of wood: RZ with lignans removed by extraction showed significantly higher mass loss than unextracted RZ when subjected to Fenton degradation. The reduced diversity and amount of lignans in pathogen-compromised RZ and decaying heartwood in comparison to intact RZ and healthy heartwood suggest that α-conindendrin isomer is an intermediate metabolite in lignan decomposition by H. parviporum. Diterpenes and diterpene alcohols constituted above 90% of the terpenes detected in sapwood of healthy and diseased trees. A significant finding was that traumatic resin canals, predominated by monoterpenes, were commonly associated with RZ. The findings clarify the roles and fate of lignan during wood decay and raise questions about the potential roles of terpenoids in signal transduction, synthesis, and translocation of defense compounds upon wood compartmentalization against decay fungi.
Pretreatment patient-reported cognitive function in patients with diffuse glioma
Authors: Schei Stine , Solheim Ole , Salvesen Øyvind , Hjermstad Marianne Jensen , Bouget David , Sagberg Lisa Millgård 
Published: February 2022

Abstract

Purpose
Cognitive function is frequently assessed with objective neuropsychological tests, but patient-reported cognitive function is less explored. We aimed to investigate the preoperative prevalence of patient-reported cognitive impairment in patients with diffuse glioma compared to a matched reference group and explore associated factors.

Methods
We included 237 patients with diffuse glioma and 474 age- and gender-matched controls from the general population. Patient-reported cognitive function was measured using the cognitive function subscale in the European Organisation for Research and Treatment of Cancer QLQ-C30 questionnaire. The transformed scale score (0–100) was dichotomized, with a score of ≤ 75 indicating clinically important patient-reported cognitive impairment. Factors associated with preoperative patient-reported cognitive impairment were explored in a multivariable regression analysis.

Results
Cognitive impairment was reported by 49.8% of the diffuse glioma patients and by 23.4% in the age- and gender-matched reference group (p < 0.001). Patients with diffuse glioma had 3.2 times higher odds (95% CI 2.29, 4.58, p < 0.001) for patient-reported cognitive impairment compared to the matched reference group. In the multivariable analysis, large tumor volume, left tumor lateralization, and low Karnofsky Performance Status score were found to be independent predictors for preoperative patient-reported cognitive impairment.

Conclusions
Our findings demonstrate that patient-reported cognitive impairment is a common symptom in patients with diffuse glioma pretreatment, especially in patients with large tumor volumes, left tumor lateralization, and low functional levels. Patient-reported cognitive function may provide important information about patients’ subjective cognitive health and disease status and may serve as a complement to or as a screening variable for subsequent objective testing.
When AI meets store layout design: a review
Authors: Nguyen Kien , Le Minh , Martin Brett , Cil Ibrahim , Fookes Clinton 
Published: February 2022

AbstractAn efficient store layout presents merchandise to attract customer attention and encourages customers to walk down more aisles which exposes them to more merchandise, which has been shown to be positively correlated with the sales. It is one of the most effective in-store marketing tactics which can directly influence customer decisions to boost store sales and profitability. The recent development of Artificial Intelligence techniques, especially with its sub-fields in Computer Vision and Deep Learning, has enabled retail stores to take advantage of existing CCTV infrastructure to extract in-store customer and business insights. This research aims to conduct a comprehensive review on existing approaches in store layout design and modern AI techniques that can be utilized in the layout design task. Based on this review, we propose an AI-powered store layout design framework. This framework applies advanced AI and data analysis techniques on top of existing CCTV video surveillance infrastructure to understand, predict and suggest a better store layout.
Anti-HER2 therapy in metastatic breast cancer: many choices and future directions
Authors: Wynn Carrie S. , Tang Shou-Ching 
Published: February 2022

AbstractMetastatic HER2 + breast cancer is an expanding area of drug development and research, with three new drugs approved in 2020 alone. While first-line therapy is well-established for metastatic HER2 + breast cancer, the standard of care for second-line therapy will likely be changing soon based on the results of the DESTINY-Breast03 trial. In the third-line setting, many options are available. Considerations in choosing between regimens in the third-line include resistance to trastuzumab, the presence of brain metastases, and tolerability. High rates of resistance exist in this setting particularly due to expression of p95, a truncated form of HER2 that constitutively activates downstream signaling pathways. We suggest a tyrosine kinase inhibitor (TKI)-based regimen because of the activity of TKIs in brain metastases and in p95-expressing tumors. Attempts to overcome resistance to anti-HER2 therapies with PI3K inhibitors, mTOR inhibitors, and CDK 4/6 inhibitors are an active area of research. In the future, biomarkers are needed to help predict which therapies patients may benefit from the most. We review the many new drugs in development, including those with novel mechanisms of action.
Optimization of nickel and cobalt biosorption by native Serratia marcescens strains isolated from serpentine deposits using response surface methodology
Authors: Díaz A. , Marrero J. , Cabrera G. , Coto O. , Gómez J. M. 
Published: February 2022

AbstractThe treatment of metal-polluted wastes is a challenging issue of environmental concern. Metals can be removed using microbial biomass, and this is an interesting approach towards the design of eco-friendly technologies for liquid waste treatment. The study reported here aimed to optimize nickel and cobalt biosorption from aqueous solutions using three native metal–resistant Serratia marcescens strains. Ni(II) and Co(II) biosorption by S. marcescens strains was found to fit better to Langmuir’s model, with maximum uptake capacities of 13.5 mg g−1 for Ni(II) ions and 19.9 mg g−1 for Co(II) ions. Different experimental conditions of initial metal concentration, pH, initial biomass, and temperature were optimized using the Plackett–Burman method, and, finally, biomass and metal concentration were studied using the response surface methodology (RSM) to improve biosorption. The optimum uptake capacities for Co(II) ions by the three biosorbents used were obtained for initial metal concentrations of 35–40 mg L−1 and an initial biomass of 6 mg. For Ni(II) ions, the optimum uptake capacity was achieved with 1 mg of initial biomass for S. marcescens C-1 and C-19, and with 7 mg for S. marcescens C-16, with initial concentrations of 20–50 mg L−1. The results obtained demonstrate the viability of native S. marcescens strains as biosorbents for Ni(II) and Co(II) removal. This study also contributes to our understanding of the potential uses of serpentine microbial populations for the design of environmental cleanup technologies.
Influence of the catchment area use on the water quality in the Utrata River
Authors: Dębska Katarzyna , Rutkowska Beata , Szulc Wiesław 
Published: February 2022

AbstractThe present paper discusses the impact of land use and seasons on the concentration of nutrients in the waters of the Utrata River (Pruszków Poviat, Mazowieckie Voivodeship) from April 2018 to March 2019. The pollution of rivers by nutrients is a major problem for society. Surface water is a source of drinking water, water used for industrial and agricultural purposes. With the increasing pollution of rivers, the purification process for these purposes becomes more expensive and more challenging. To assist in carrying out activities aimed at reducing the inflow of biogenic substances into large river systems and then down to the Baltic Sea, we analyzed the spatial and temporal dynamics of loads from the entire Utrata River catchment area. We divided the entire catchment area into three impact zones: grasslands and wastelands, urbanized areas, and agricultural land and examined changes in nutrient concentrations (total phosphorus, nitrate nitrogen, ammonium nitrogen) in each of the zones. The results were statistically processed using the 1-factor ANOVA method with the p-value of significance below 0.05. Research indicates an increase in the concentration of total phosphorus and nitrogen forms down the course of the river in urban and agricultural areas with persistently low concentrations of these biogenic substances in grasslands.
Stability Charts for Closely Spaced Strip Footings on Hoek–Brown Rock Mass
Authors: Keawsawasvong Suraparb , Shiau Jim , Limpanawannakul Khemmapa , Panomchaivath Suttikarn 
Published: February 2022

AbstractFootings are constructed closely to each other in mountainous rock areas and the determination of closely spaced bearing capacity footings on rock masses has become an important topic of recent research. The primary aim of this paper is to determine an efficiency factor, just like in the design of a pile group, that can be used to evaluate the bearing capacity of closely spaced footings on Hoek–Brown mass. The advanced finite element limit analysis of upper and lower bound theorems is used to study the stability of two and multiple interfering footings using the Hoek–Brown parameters such as GSI (geological strength index) and mi (Hoek–Brown yield parameter). This study found that the efficiency factor is influenced by three dimensionless parameters including GSI, mi, and S/B. Failure mechanisms of the problems are also investigated, and stability charts and tables produced for practical uses. Overall, these results broadly support the common understanding of the two key parameters GSI and mi in the HB failure criterion. As a result of these investigations, suggestions were identified for future research.
How Does Confucianism Influence Health Behaviors, Health Outcomes and Medical Decisions? A Scoping Review
Authors: Badanta Barbara , González-Cano-Caballero María , Suárez-Reina Paola , Lucchetti Giancarlo , de Diego-Cordero Rocío 
Published: February 2022

AbstractThe aim of this study is to analyze the influence of Confucianism on health behaviors, health outcomes and medical decisions. The research was conducted using the following databases: PubMed, Scopus, CINHAL, PsycINFO and Web of Science, without restrictions of language and year of publication. The search process identified 833 publications matching the search criteria, and after the review process, 40 articles were included. Family is a central aspect of Confucianism, and it seems to affect participation in medical decisions, taking care of relatives, ethical dilemmas and mental health problems. Although most Confucianist influence seems to be positive, some ways of thinking could increase suffering, burnout and a delay in healthcare seeking. Understanding these values could help health professionals to deal with the growing contingent of patients with different cultures and religious beliefs.
Facilitation of Entrepreneurial Discovery Processes by Policymakers: an Actionable Definition of Roles and Challenges
Authors: Estensoro Miren , Larrea Miren 
Published: February 2022

AbstractThe objective of this paper is to contribute to the academic literature with an actionable framework of the roles of policy makers in entrepreneurial discovery processes (EDP) in the context of smart specialisation strategies (S3). The methodology used to define such roles is action research and, consequently, they are the result of learning and negotiation between policy makers and other territorial stakeholders facilitated by action researchers. The case study is based in the Bilbao Next Lab project (Bilbao, Basque region, Spain) where this methodology was chosen because policy makers wanted to explore EDP through collaborative governance. The key findings have been integrated in a framework named as the six roles of facilitative policymakers in EDPs. Its actionability is visible in the connection of the framework with the dilemmas, difficulties, and problems faced by policy makers when facilitating EDP processes. The framework is presented together with a discussion on the relevance of including tailored capacity development processes for policymakers as part of the EDP. The paper concludes with a final reflection on how the need for a facilitative role of policymakers also requires a transformation of research methodologies by social researchers.
On Foster–Lyapunov criteria for exponential ergodicity of regime-switching jump diffusion processes with countable regimes
Authors: Kunwai Khwanchai 
Published: February 2022

AbstractThis paper is devoted to the study of regime-switching jump diffusion processes with countable regimes. It aims to establish Foster–Lyapunov-type criteria for exponential ergodicity of such processes. After recalling results concerning the petiteness of compact sets, this paper presents sufficient conditions for the existence of a Foster–Lyapunov function; this, in turn, helps to establish sufficient conditions for the desired exponential ergodicity for regime-switching jump diffusion processes. Finally, an application to feedback control problems is presented.
Abduction and Composition
Authors: Aizawa Kenneth , Headley Drew B. 
Published: February 2022

AbstractSome New Mechanists have proposed that claims of compositional relations are justified by combining the results of top-down and bottom-up interlevel interventions. But what do scientists do when they can perform, say, a cellular intervention, but not a subcellular detection? In such cases, paired interlevel interventions are unavailable. We propose that scientists use abduction and we illustrate its use through a case study of the ionic theory of resting and action potentials.
Severity and Trustworthy Evidence: Foundational Problems versus Misuses of Frequentist Testing
Authors: Spanos Aris 
Published: February 2022

AbstractFor model-based frequentist statistics, based on a parametric statistical model${{\cal M}_\theta }({\bf{x}})$, the trustworthiness of the ensuing evidence depends crucially on (i) the validity of the probabilistic assumptions comprising${{\cal M}_\theta }({\bf{x}})$, (ii) the optimality of the inference procedures employed, and (iii) the adequateness of the sample size (n) to learn from data by securing (i)–(ii). It is argued that the criticism of the postdata severity evaluation of testing results based on a smallnby Rochefort-Maranda (2020) is meritless because it conflates [a] misuses of testing with [b] genuine foundational problems. Interrogating this criticism reveals several misconceptions about trustworthy evidence and estimation-based effect sizes, which are uncritically embraced by the replication crisis literature.
Ethnography, Archaeology, and the Late Pleistocene
Authors: Sterelny Kim 
Published: February 2022

AbstractThe use of ethnography to understand archaeology is both prevalent and controversial. This paper develops an alternative approach, using ethnography to build and test a general theory of forager behaviors, and their variations in different conditions, one which can then be applied even to prehistoric sites differing from contemporary experience. Human behavioral ecology is chosen as the framework theory, and forager social learning as a case study. The argument is then applied to social learning in the late Pleistocene, and hence to a famous archaeological puzzle: the late Pleistocene acceleration of technical innovation and regional differentiation.
Acrylic bone cement with Tutopatch for frontal sinus obliteration
Authors: Demir B 
Published: February 2022

AbstractObjectiveTo evaluate the use of acrylic bone cement with a Tutopatch collagen implant for frontal sinus obliteration after mucocele excision using a subjective assessment of patient satisfaction.MethodsPatients with a recurrent frontal sinus mucocele with posterior table erosion, for whom an endoscopic approach was not feasible, and who underwent osteoplastic frontal sinus obliteration, were included. The post-operative outcomes were evaluated using a non-standardised questionnaire, comparing pre- and post-operative scores.ResultsAll patients expressed post-operative satisfaction. Except for hyposmia, significant improvements were observed in all symptom scores. No major complications were observed during the post-operative course.ConclusionAcrylic bone cement with Tutopatch can be effectively used in frontal sinus reconstruction in cases where an endoscopic approach is not feasible.
Generalizability in mixed models: Lessons from corpus linguistics
Authors: Van de Velde Freek , De Pascale Stefano , Speelman Dirk 
Published: February 2022

AbstractPart of the generalizability issues that haunt controlled lab experiment designs in psychology, and more particularly in psycholinguistics, can be alleviated by adopting corpus linguistic methods. These work with natural data. This advantage comes at a cost: in corpus studies, lexemes and language users can show different kinds of skew. We discuss a number of solutions to bolster the control.
A crisis of generalizability or a crisis of constructs?
Authors: King Kevin M. , Wright Aidan G.C. 
Published: February 2022

AbstractPsychologists wish to identify and study the mechanisms and implications of nomothetic constructs that reveal truths about human nature and span across operationalizations. To achieve this goal, psychologists should spend more time carefully describing and measuring constructs across a wide range of methods and measures, and less time rushing to explain and predict.