bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anais 2º Simpósio de Pediatria de Três Lagoas - Pediatria Inclusiva/ LAPED – UFMS – Três Lagoas
Authors: Parduci Natália Varreira , Freitas Alisson Kelvin Pereira Borges , Ricci Raquel Cordeiro , Silva Leonan José de Oliveira e , Ribeiro Isabela Crispim , Cabral Milla Bitencourt , Oda Julie Massayo Maeda 
Published: July 2022

Caro (a) Leitor (a),
O 2º Simpósio de Pediatria de Três Lagoas: Pediatria Inclusiva foi realizado nos dias 01, 02 e 05 de junho de 2021. O evento foi organizado pelos membros da Liga Acadêmica de Pediatria da Universidade Federal de Mato Grosso do Sul, Campus de Três Lagoas (UFMS/CPTL), com auxílio de outros discentes e docentes do curso de Medicina da mesma instituição. Em respeito às normas de distanciamento social durante o período de pandemia de COVID-19, o simpósio ocorreu de maneira virtual por meio da transmissão via plataforma de streaming no canal da liga no YouTube. O principal objetivo desse evento foi promover a disseminação do conhecimento baseado em evidências acerca da importância da pediatria inclusiva. Isto é, nossa intenção foi promover uma visão mais humanizada bem como um cuidado integral e multidisciplinar que abarque o máximo possível dos aspectos que circundam as crianças com deficiência, desde os seus primeiros momentos de vida. Para isso, o simpósio contou com a participação, em dois dias, de profissionais conceituados na área, os quais ministraram palestras na temática de inclusão com uma abordagem multidisciplinar. Junto a isso, houve espaço para a submissão de trabalhos científicos, os quais foram classificados em apresentações do tipo banner ou orais, sendo os melhores premiados com menção honrosa. O Evento foi um sucesso em todos os aspectos. Dessa forma, deixamos aqui nosso agradecimento a todos que colaboraram e participaram!
Osteocondroma em Articulação Temporomandibular: Relato de Caso
Authors: Aires Carolina Chaves Gama , Cavalcanti Thames Bruno Barbosa , Souza Rosa Rayanne Lins de , Viana Ruan de Sousa , Pinto Priscilla Sarmento , Lago Carlos Augusto Pereira do , Vasconcellos Ricardo José de Holanda 
Published: July 2022

O osteocondroma é considerado um tumor ósseo benigno que ocorre principalmente em ossos longos, raramente afetando o complexo maxilofacial, porém quando presentes presentes nessa região, tem uma predileção pela mandíbula.coronóide. Geralmente ocorre na faixa etária entre 10 e 30 anos. Quando em côndilo mandibular, podem ocasionar deformidades dento-faciais, resultando em limitação de abertura bucal, maloclusão e assimetria facial. O objetivo do presente trabalho foi relatar o caso de uma paciente do sexo feminino, de 36 anos, encaminhada para a correção de discrepância maxilomandibular, cujos exames complementares evidenciaram a presença de osteocondroma em côndilo mandibular esquerdo. Mediante o quadro optou-se pela ressecção cirúrgica do tumor, através de condilectomia baixa e reanatomização condilar, seguida pelo tratamento ortodôntico pós-operatório. A remoção total da lesão associado a uma reconstrução articular e posterior tratamento ortodôntico foi eficaz em devolver a função articular e a estética da paciente, visto que houve uma melhora significativa da simetria facial. Após 3 anos, a paciente segue em acompanhamento, sem sinais de recidiva.
Relação entre a Diabetes Mellitus Gestacional e a Doença Periodontal: uma Revisão Atual
Authors: Silveira Karoline Alves , Lima Laís Medeiros Simões de , Dias Caldeira Francois Isnaldo , Pigossi Suzane Cristina , Rodriguez Larissa Santana 
Published: July 2022

A doença periodontal (DP) é um processo inflamatório, comum e complexo, caracterizada pela destruição dos tecidos periodontais de suporte, e foi avaliada quanto a um papel potencial no desenvolvimento do diabetes mellitus gestacional (DMG). O objetivo deste trabalho foi realizar um levantamento bibliográfico, sobre a relação entre a DMG e a DP. Foram realizadas buscas virtuais nas bases de dados PubMed/Medline até junho de 2021, e incluídos os estudos na língua inglesa, publicados nos últimos dez anos. Para tanto foram utilizados os seguintes descritores na língua inglesa: gestational diabetes e periodontal diseases. Dentro desta busca, foram encontrados 71 artigos, dos quais após o processo de triagem, foram excluídos 53 estudos por não responderem a pergunta norteadora. Assim, totalizando 18 pesquisas originais que compuseram esta revisão de literatura narrativa. Os estudos demonstraram que a periodontite atua como fator de risco para o desenvolvimento da DMG, e conhecer os determinantes sociais da saúde envolvidos no processo saúde-doença da doença periodontal, podem ajudar a estabelecer uma ligação entre estas comorbidades que afetam essa parcela da população.
Role of Tyrosine Kinases and their Inhibitors in Cancer Therapy: A
Comprehensive Review
Authors: Kumar Vanktesh , Kaur Navjot , Sahu Sanjeev , Sharma Vikas , Kumar Deepak , Sharma Ajit , Wadhwa Pankaj 
Published: July 2022

Abstract:
Recently released Globocan-2020 report has been disclosed an increase in new cancer cases, cancer deaths, and 5-year prevalence cases worldwide. The higher percent proportions of cancer deaths as compared to their incidence percentage in Asia and Africa. Cancer is a genetic but not inheritable disease that consists of various abnormal cells. Depending upon the nature and site of availability of cells cancer can spread all over the body. These abnormal cells can grow infinitely in which tyrosine kinases (TKs) play an important role as mediators for cellular signal transduction processes during migration, metabolism, proliferation and differentiation, apoptotic cell death, etc. TKs belong to a specific family of an enzyme that catalyses the transferring of phosphate groups from ATP to selected tyrosine residues of a target protein during the biological process to maintain the homeostasis. They work in various steps of development and progression pathways of cancer by affecting signal transduction. The aberrant and deregulated functioning of TKs results in a defective signal transduction pathway which leads to abnormality in cell transformation, proliferation, and differentiation, thus the development of cancer. Since their discovery in 1990 to date, more than 90 TKs have been reported and divided into two categories receptor and non-receptor TKs. Higher expression levels of TKs paved their status of oncoprotein and thus, they provide a potential target for the development of anti-cancer therapeutics. Here, we provided updated cancer demographic status, cancer types, and available therapeutic options targeted cancer therapeutic strategies and the role of different TKs in cancers along with recently identified molecules that target TKs. Moreover, we also included the binding interactions of chemical inhibitors with TKs.
The Role of Water Network Chemistry in Proteins: A Structural Bioinformatics Perspective in Drug Discovery and Development
Authors: Sobhia Masilamani Elizabeth , Ghosh Ketan , Kumar Gajjala Siva , Sivangula Srikanth , Laddha Kapil , Kumari Sonia , Kumar Harish 
Published: July 2022

Background:Although water is regarded as a simple molecule, its ability to create hydrogen bonds makes it a highly complex molecule that is crucial to molecular biology. Water mo-lecules are extremely small and are made up of two different types of atoms, each of which plays a particular role in biological processes. Despite substantial research, understanding the hydration chemistry of protein-ligand complexes remains difficult. Researchers are working on harnessing water molecules to solve unsolved challenges due to the development of computer technologies.Objective:The goal of this review is to highlight the relevance of water molecules in protein envi-ronments, as well as to demonstrate how the lack of well-resolved crystal structures of proteins fun-ctions as a bottleneck in developing molecules that target critical therapeutic targets. In addition, the purpose of this article is to provide a common platform for researchers to consider numerous as-pects connected to water molecules.Conclusion:Considering structure-based drug design, this review will make readers aware of the different aspects related to water molecules. It will provide an amalgamation of information related to the protein environment, linking the thermodynamic fingerprints of water with key therapeutic targets. It also demonstrates that a large number of computational tools are available to study the water network chemistry with the surrounding protein environment. It also emphasizes the need for computational methods in addressing gaps left by a poorly resolved crystallized protein structure.
Host Cell Proteases Mediating SARS-CoV-2 Entry: An Overview
Authors: Oubahmane Mehdi , Hdoufane Ismail , Bjij Imane , Lahcen Nouhaila Ait , Villemin Didier , Daoud Rachid , Allali Achraf El , Cherqaoui Driss 
Published: July 2022

Abstract:The outbreak of the SARS-CoV-2 virus in late 2019 and the spread of the COVID-19 pandemic have caused severe health and socioeconomic damage worldwide. Despite the significant research effort to develop vaccines, antiviral treatments, and repurposed therapeutics to effectively contain the catastrophe, there are no available effective vaccines or antiviral drugs that can limit the threat of the disease, so the infections continue to expand. To date, the search for effective treatment remains a global challenge. Therefore, it is imperative to develop therapeutic strategies to contain the spread of SARS-CoV-2. Like other coronaviruses, SARS-CoV-2 invades and infects human host cells via the attachment of its spike envelope glycoprotein to the human host cell receptor hACE2. Subsequently, several host cell proteases facilitate viral entry via proteolytic cleavage and activation of the S protein. These host cell proteases include type II transmembrane serine proteases (TTSPs), cysteine cathepsins B and L, furin, trypsin, and Factor Xa, among others. Given the critical role of the host cell proteases in coronavirus pathogenesis, their inhibition by small molecules has successfully targeted SARS-CoV-2 in vitro, suggesting that host cell proteases are attractive therapeutic targets for SARS-CoV-2 infection. In this review, we focus on the biochemical properties of host cell proteases that facilitate the entry of SARS-CoV-2, and we highlight therapeutic small molecule candidates that have been proposed through in silico research.
Analisis Kemampuan Pemecahan Masalah Matematika Ditinjau Dari Gaya Kognitif Reflektif dan Impulsif Siswa Kelas VII.B SMPN 4 Solok Selatan
Authors: Hidayah Shinta , Yunita Alfi , Muslim Audra Pramitha 
Published: July 2022

ABSTRACT This research is motivated by the low ability of students’ mathematical problem solving and students’ cognitive style in solving problems. the purpose of this study was to determine how thw mathematical problem solving ability in term of the reflective abd impulsive cognitive style of class VIIB students of SMPN 4 South Solok. This type of research is descriptive research with a qualitative approach. The sampling technique used was purposive sampling. The research instrument was in the form the Matching Familiar Figure Test (MFFT), mathematics problem-solving ability test and interviews. Data analysis techniques using qualitative data analysis techniques are data reduction, data presentation and drawing conclusios. The result showed that who had the criteria of problem solving ability and reflective cognitive style of class VIIB students as many as 9 people consisting of 1 person who had low and very low problem solving ability criteria. Students who have the criteria of problem solving ability and cognitive style of class VIIB students are 6 people sonsiting of 1 person who has low problem solving ability criteria and very low people.ABSTRAK Penelitian ini dilatarbelakangi oleh rendahnya kemampuan pemecahan masalah matematika siswa dan gaya kognitif siswa dalam menyelesaikan masalah. Tujuan penelitian ini adalah untuk mengetahui bagaimana kemampuan pemecahan masalah. Tujuan penelitian ini adalah untuk mengetahui bagaimana kemampuan pemecahan masalah matematika ditinjau dari gaya kognitif dan impulsive siswa kelas VIIB SMPN 4 Solok Selatan. Jenis penelitian deskriptif dengan pendekatan kualitatif. Teknik pengambilan sampel menggunakan purposive sampling. Instrumen penelitian berbentuk tes Matching Familiar Figure Test (MFFT), tes kemampuan pemecahan masalah matematika dan wawancara. Teknik analisis data yang menggunakan teknik analisis data kualitatif yaitu reduksi data, penyajian data dan penarikkan kesimpulan. Hasil penelitian menunjukkan bahwa siswa yang memiliki kriteria dari kemampuan pemecahan masalah dan gaya kognitif reflektif siswa kelas VIIB 9 orang yang terdiri 1 orang memiliki kriteria kemampuan pemecahan masalah rendah dan sangat rendah 8 orang. Siswa yang memiliki kriteria kemampuan pemecahan masalah dan gaya kognitif impulsive kelas VIIB sebanyak 6 orang yang terdiri 1 orang yang memiliki kriteria kemampuan pemecahan masalah rendah dan sangat rendah 5 orang.
SÍNDROME DE BURNOUT: COMO ENFERMEIROS EMERGENCISTAS VIVENCIAM E LIDAM COM OS ELEMENTOS QUE A CARACTERIZAM?
Authors: De Oliveira Moreira Poliane , Carlos Honório Luiz 
Published: July 2022

Objetivo: descrever e analisar o trabalho dos enfermeiros que atuam nos serviços de urgência e emergência de um hospital público de Belo Horizonte.
Método / abordagem: a pesquisa é descritiva, com abordagem qualitativa, utilizando o estudo de caso como método.
Principais resultados: Na dimensão exaustão emocional os resultados apontaram para sobrecarga e esgotamento no trabalho. Na dimensão despersonalização, os enfermeiros têm conhecimento a respeito dos impactos que situações do trabalho e problemas dos pacientes podem exercer sobre eles e na dimensão baixa realização profissional os enfermeiros disseram insatisfeitos com o salário que recebem e sentem-se desvalorizados.
Contribuições metodológicas / sociais / gerenciais: ampliação do conhecimento sobre o fenômeno Síndrome de burnout, por meio de abordagem qualitativa, uma vez que, as pesquisas sobre o tema têm em sua maioria, abordagem quantitativa.
Originalidade / relevância: Na literatura brasileira, encontram-se poucos estudos sobre o tema, realizado apenas com enfermeiros e com abordagem qualitativa.
Peran Pendidikan Islam dalam Pelaksanaan Otonomi Pendidikan di Indonesia
Authors: Mansir Firman 
Published: July 2022

This article describes the role of Islamic education in the implementation of educational autonomy that occurs in Indonesia, both in Islamic educational institutions and in general education institutions. The results of the study indicate that Islamic education plays a major role in the implementation of educational autonomy. This is because Islamic education is a separate part that is able to implement its curriculum in Islamic educational institutions. This research is a literature study so that the data analyzed are sourced from various literature references by using literature analysis in revealing the data. Thus, the implementation of educational autonomy in various Indonesian educational institutions goes well together in accordance with the educational and learning objectives to be achieved. In the context of Islamic education itself, the entire PAI curriculum is able to synergies with other subjects implemented in schools and madrasa.
Karakteristik Fisikokimia dan Organoleptik Food Bars Tepung Jahe dan Tempe
Authors: Panjaitan Raini , Irwanto Reno , Manurung Jelita , Cholilluloh Andreais Boffil , Pane Yolanda 
Published: July 2022

Salah satu bentuk bahan pangan yang dapat dikembangkan sebagai produk preventif pada masa pandemi adalah food bars yang terbuat dari tepung jahe dan tempe. Tujuan penelitian ini adalah untuk menghasilkan pangan fungsional yang kaya kandungan gizi dan dapat diterima konsumen dimasa pandemi Covid-19. Jenis penelitian adalah penelitian true experiment dengan desain penelitian Rancangan Acak Lengkap (RAL). Penelitian ini dilakukan dengan 3 taraf yaitu P1: tepung jahe 30% dan tempe 70%, P2: tepung jahe 40% dan tempe 60% dan P3: tepung jahe 50% dan tempe 50%. Karakterisasi tepung jahe dan produk food bars meliputi karakterisasi kimia dan organoleptik. Uji kadar air, protein, dan lemak menunjukkan bahwa semakin banyak proporsi tempe yang ditambahkan pada campuran maka kadar air, protein, dan lemak semakin banyak. Proporsi yang sama antara tepung jahe dan tempe menunjukkan peningkatan kandungan mineral. Semakin besar jumlah proporsi jahe maka kandungan karbohidrat semakin tinggi. Uji organoleptik berdasarkan parameter tekstur, warna, aroma dan rasa pada produk food bars tepung jahe dan tempe dikategorikan suka. Kesimpulan yang didapatkan dari penelitian ini berdasarkan uji organoleptik dan karakteristik kimia pada produk food bars tepung jahe dan tempe yang terpilih adalah perlakuan P3 yaitu 50% tepung jahe dan 50% tempe.
Liver derived S100A6 propels β cell dysfunction in NAFLD
Authors: Dogra Surbhi , Das Debajyoti , Maity Sujay K. , Paul Avishek , Rawat Priya , Daniel P Vineeth , Das Kausik , Mitra Souveek , Chakrabarti Partha , Mondal Prosenjit 
Published: July 2022

<p>Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of systemic insulin resistance and type 2 diabetes mellitus (T2DM). However, converse correlates between excess liver fat content and β-cell function remain equivocal. Specifically, how the accumulation of liver fat consequent to the enhanced <em>de novo</em> lipogenesis (DNL) leads to pancreatic β-cell failure and eventually to T2DM is elusive. Here we have identified low-molecular-weight calcium-binding protein S100A6 or calcyclin inhibits glucose-stimulated insulin secretion (GSIS) from β-cells through activation of the receptor for the advanced glycation end product (RAGE) and diminution of mitochondrial respiration. Serum S100A6 level is elevated both in human NAFLD patients and in a high-fat diet (HFD) induced mouse model of NAFLD. While serum S100A6 levels are negatively associated with β-cell insulin secretory capacity in human patients, depletion of hepatic S100A6 improves GSIS and glycemia in mice suggesting that S100A6 contributes to the pathophysiology of diabetes in NAFLD. Moreover, transcriptional induction of hepatic S100A6 is driven by the potent regulator of DNL, carbohydrate response element-binding protein (ChREBP), and ectopic expression of ChREBP in the liver suppresses GSIS in a S100A6 sensitive manner. Together, these data suggest elevated serum levels of S100A6 may serve as a biomarker in identifying NAFLD patients with a heightened risk of developing β-cell dysfunction. Overall, our data, implicate S100A6 as a hitherto unknown hepatokine to be activated by ChREBP and participates in the hepato-pancreatic communication to impair insulin secretion and drive the development of T2DM in NAFLD. </p>
META ANALYSIS OF THE EFFECT OF THE USE OF MODULE ON STUDENTS' CRITICAL THINKING ABILITY IN PHYSICS AND SCIENCE COURSES
Authors: Syahmi Hasya , Darvina Yenni , Desnita . , Murtiani . 
Published: July 2022

The twenty-first century is evolving at an incredible rate.. The development of information and communication technology in all aspect of life, including in the learning process has entered the modern era. The ablility to think critically and solve problems skill (problem solving skill) are important skills for surviving in the twenty-first century. The real condition found in the field were that students' critical thinking skills are relatively low during the teaching and learning process. One solution to overcoming this problem is to use learning media namely in the form of modules. Then, it is necessary to have further research on the Module. Meta-analysis is the term for this type of study. Researchers undertake meta-analysis by synthesizing research data, examining, and analyzing research data from a number of previously published studies. Conducting a literature review, gathering data, studying and assessing papers, analyzing and interpreting articles, and producing report results are all steps in meta-analysis. The necessary statistical data must be included in the article, according to the standard. From the data analysis carried out, it can be stated three results of this research. First, the use of the module has a significant effect on the senior high school level compared with an average effect of 0.931 to junior high school level. Second, the use of the module has a significant effect on the Newton’s Gravity material with an average effect of 3.742. Third, the use of the module has a significant effect by using a Contextual Teaching and Learning Model and saintific approach.
Buku Cerita Bergambar Cerdas Makan Ikan Untuk Usia 6-10 Tahun
Authors: Zahra Shifa Marlia , Afriwan Hendra 
Published: July 2022

Asupan gizi anak pada usia dini mempengaruhi tumbuh kembang anak di masa depan.Asupan gizi seperti, karbohidrat, protein, lemak, mineral dan lainnya merupakan sumber asupan yang diperlukan untuk tumbuh kembang anak. Salah satu makanan yang kaya akan asupan gizi yaitu, ikan. Berbagai sumber zat gizi terdapat dalam daging ikanseperti protein, lemak, vitamin, mineral, dan lainnya yang membantu tumbuh kembanganak. Namun konsumsi ikan di kalangan masyarakat terutama pada anak-anak lebihrendah daripada konsumsi ayam dan telur. Masih kurangnya media informasi yang menyampaikan perihal keunggulan mengonsumsi ikan menjadikan anak acuh tidak acuh terhadap tumbuh kembang. Salah satu cara memperkenalkan kebiasaan mengonsumsiikan di kalangan anak-anak dengan memilih media informasi buku cerita bergambar.Cerita ringan dan penuh warna akan menarik anak untuk membaca dan menyerap informasi yang ingin disampaikan dari buku. Metode perancangan yang digunakanya itumetode4-D(Define,Design,Develope,Dissminate) san teknik analisa 5W+1H (What, When, Where, Who, Why, dan How).Selain media utama buku cerita bergambar, perancanganan ini juga memiliki mediapendukung seperti, tote bag, pouch sendok, kotak bekal, postcard, tumbler, posterooficial,danx-banner.
Redesign Visual Identity Violet.id di Nagari Koto Tuo Sijunjung
Authors: Hitoshi Ahmad , Pebriyeni Elya 
Published: July 2022

Redesign visual identity ini bertujuan untuk menciptakan citra yang baru kepada perusahaan Violet.id yang bergerak pada bidang komunikasi ini dimata konsumen. Berlandaskan pada permasalahan yang ditemui, Violet belum memiliki citra yang kuat sebagai perusahaan yang bergerak di bidang komunikasi serta pembeda dengan identitas jenis perusahaan lain. Permasalahan lain yang ditemui adalah belum konsistennya penerapan identitas visual yang dijumpai pada media. Dilihat dari permasalahan tersebut maka digunakanlah metode kotak kaca yang terdiri dari beberapa tahapan yaitu persiapan, inkubasi, luminasi dan verifikasi. Metode kotak kaca di awali dengan tahap pengumpulan data dan persiapan kelengkapan, mencari kata kunci, proses perancangan media dan penerapan pada media. Pada final redesign visual identity Violet.id akan menghasilkan rancangan identitas visual baru yang memiliki cirikhas dan nantinya bermanfaat meningkatkan nilai brand di mata konsumen. Selain itu, dirancang beberapa media seperti manual book, purwarupa landing page, voucher internet, polo shirt, t shirt, safety helmet, stiker, poster, roll banner, dan kartu nama.