bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrostimulation of the white matter of the posterior insula and medial operculum: perception of vibrations, heat, and pain
Authors: Mandonnet Valéry , Rheault François , Descoteaux Maxime , Devaux Bertrand , Levé Charlotte , Froelich Sébastien , Mandonnet Emmanuel 
Published: September 2022

Abstract
Objectives
The aim of this study was to characterize the sensory responses observed when stimulating electrically the white matter surrounding the posterior insular point.
Methods
We reviewed patients operated on under awake conditions for a glioma located in the vicinity of the posterior insular point. Patients’ reports of perceived sensations under electrical stimulation were retrospectively collected. Stimulation points were manually located in the postoperative MRI and further registered to the MNI template.
Results
Twelve stimulation points in eight patients were analyzed. Painful sensations in the leg were reported in 6 cases, at the level of the posterior part of the superior insular sulcus. Pain had diverse qualities: burning, tingling, crushing, or electric shock. More laterally, in the white matter of the parietal operculum, heat sensations were described, with a mesio-lateral somatotopy, with from mesial to lateral, lower limb – trunk and/or superior limb – face. Finally, vibration sensations were also reported, intermingled with pain and heat areas. In relation to Glasser atlas, pain sites abutted OP2/3 parcel, while heat sites were located within OP1.
Conclusion
The white matter surrounding the posterior insula and medial operculum constitutes a sensory hub, at the cross-road of triangular connections, linking two at a time the primary somatosensory area, the secondary somatosensory area, and the thalamus. Its surgical preservation is of utmost importance to prevent the postoperative onset of a debilitating insulo-opercular pain syndrome.
Does Family Functioning contribute to the Satisfaction with Life among Iranian University Students during COVID-19 Outbreak?
Authors: Zarei Salman , Fooladvand Khadijeh 
Published: September 2022

Abstract

Background Research has found that family functioning is positively associated with satisfaction with life. However, further investigations are needed for internal mechanisms of this relationship. On the other hand, the COVID-19 pandemic has been shown to decrease life satisfaction. We examined the protective impacts of family functioning, hope and resilience on life satisfaction of university students in COVID-19 pandemics. Methods This cross-sectional online survey was conducted during the COVID-19 pandemic, between July and December 2021, in Iran. A total of 480 students were recruited from Lorestan University. The State Hope Scale (SHS), Satisfaction with Life Scale (SWLS), Family APGAR Index, and Connor-Davidson Resilience Scale (CD-RISC) collected data. Data were analyzed by pearson’ correlation analysis and structural equation modeling. Results Family functioning showed a statistically significant direct effect on hope (β = .41, P < .001), on resilience (β = .39, P < .001) and on life satisfaction (β = .27, P < 0.01). Also, according to the bootstrapping findings, the mediating effect of hope (indirect effect = .21) and resilience (indirect effect = .18) in the association between family functioning and life satisfaction was reliable. Conclusion Family functioning, hope and resilience are three important factors influencing university students’ life satisfaction. Interventions to increase family functioning and hope and resilience are needed to elevate life satisfaction for university students.
A common variant close to the “trip-wire” linker region of NLRP1 contributes to severe COVID-19
Authors: Leal Vinicius N. C. , Paulino Leandro M. , Cambui Raylane A. G. , Zupelli Thiago G , Yamada Suemy M. , Oliveira Leonardo A.T. , Dutra Valéria F. , Bub Carolina B. , Sakashita Araci M. , Yokoyama Ana Paula H. , Kutner José M. , Vieira Camila A. , Santiago Wellyngton M. S. , Andrade Milena M. S. , Teixeira Franciane M. E. , Alberca Ricardo W. , Gozzi-Silva Sarah C. , Yendo Tatiana M. , Netto Lucas C. , Duarte Alberto J. S. , Sato Maria N. , Venturini James , Pontillo Alessandra 
Published: September 2022

Abstract
Objective and design: The heterogeneity of response to SARS-COV-2 infection is directly linked to the individual genetic background. Genetic variants of inflammasome related genes have been pointed as risk factors for several inflammatory sterile and infectious disease. In the group of inflammasome receptors, NLRP1 stand out as a good novel candidate as severity factor for Covid-19 disease. Methods: To address this question, we performed an association study of NLRP1, DPP9, CARD8, IL1B and IL18 single nucleotide variants (SNVs) in a cohort of 945 Covid-19 patients. Results: The NLRP1 p.Leu155His in the linker region, target of viral protease, was significantly associated to Covid-19 severity, which could contribute to the excessive cytokine release reported in severe cases.
Fusobacterium Bacteremia Presenting with Mesenteric Vein Thrombosis
Authors: Sapkota Surendra , Shrestha Suraj , Solis Lauren A. , Kalla Abhishek 
Published: September 2022

Abstract
Background
Fusobacterium species are fastidious gram-negative anaerobes that frequently colonize the human oral cavity. Portal and mesenteric thrombosis associated with Fusobacterium are case-reportable; due to the rarity of these reports. Isolated mesenteric vein thrombosis from these species is even rarer.
Case presentation
A 59-year-old Caucasian male presented to the emergency department with a week of back pain and malaise. A CT abdomen and pelvis demonstrated an acute/early subacute partially occlusive thrombosis of the inferior mesenteric vein. Patient was discharged the same day with apixaban 5 mg twice daily. Attempts were made by the providers to contact the patient when one of the two bottles grew Fusobacterium species, but the patient didn’t respond. Patient presented to the hospital 2 weeks later with similar complaints. Patient was treated with intravenous piperacillin-tazobactam and discharged on amoxicillin-clavulanic acid for four weeks. A follow up CT in 2 months showed resolution of the thrombus. Patient completed 3 months of anticoagulation with apixaban.
Conclusion
We aim to increase physicians’ awareness regarding association of Fusobacterium to thrombosis at various sites. An early treatment of this condition with antibiotics and anticoagulation can prevent complications and result in favorable outcomes.
Study on the relationship between serum iodine and dysfunctions: a cross-sectional study
Authors: Xu Tingting , Guo Wenxing , Ren Zhiyuan , Wei Hongyan , Tan Long , Zhang Wanqi 
Published: September 2022

Abstract
The relationship between serum iodine and thyroid dysfunctions in male and female adults is poorly understood. This study aimed to explore the relationship between serum and urine iodine and thyroid dysfunction in male and female adults. A total of 1320 participants were included in the final analysis. We collected basic demographic information, as well as blood and spot urine samples, to determine serological indices and iodine nutritional status of subjects. The median (IQR) of UIC, UIC/UCr, SIC were 155.8 (94.5, 211.1) µg/L, 138.1 (91.1, 207.6) µg/g and 70.6 (59.8, 83.9) µg/L, respectively. SIC was positively correlated with UIC and UIC/UCr (P < 0.001, P < 0.001). The prevalence of hypothyroidism and subclinical hypothyroidism in female was significantly higher than that in male (P = 0.02, P = 0.002). In male subjects, subjects with SIC༞97.1 µg/L had a higher risk of hyperthyroidism (OR = 2.91, 95% CI: 1.38, 6.19) and overt hypothyroidism (OR = 5.59, 95% CI: 1.88, 6.42). In female subjects, subjects with SIC < 49.3 µg/L had a higher risk of overt hypothyroidism (OR = 2.18, 95% CI: 1.10, 4.06), TgAb positive (OR = 1.97, 95% CI: 1.15, 3.32) and TPOAb positive(OR = 2.48, 95% CI: 1.41, 4.26). In conclusion, serum iodine can be used as an indicator to evaluate iodine nutritional status and thyroid dysfunctions. Higher serum iodine concentration was associated with an increased risk of hyperthyroidism and overt hypothyroidism in men, lower serum iodine concentration was associated with an increased risk of overt hypothyroidism and positive TgAb and TPOAb in women.
Major Challenges Encountered by Novice EFL Teachers: A Meta-synthesis
Authors: DİNÇER PINAR 
Published: September 2022

Abstract

The first years of teaching are well documented to pose several challenges for novice teachers as their knowledge and skills of pre-service years are tested within real-life classroom settings. Accordingly, the current meta-synthesis paper aims to outline the challenges novice EFL teachers face to draw a general picture of the challenges recorded in the current literature and to establish guidelines for future studies. To this end, qualitative studies investigating novice ELF teachers’ challenges were scanned and filtered according to inclusion and exclusion criteria, revealing a total of 12 studies published in peer-reviewed journals within the last decade (i.e., 2010-2020). Subsequently, the results of the studies at hand were subjected to thematic analysis revealing four overarching themes: 1) Student-related challenges, 2) Lack of professional knowledge and expertise, 3) Workplace-related challenges, and 4) Educational system-related challenges.
Transformation of chronic lymphocytic leukemia into acute mixed phenotype leukemia myeloid/T neoplasm: a rare case report
Authors: Babaheidarian Pegah , Sadeghipour Alireza , Ansarinejad Nafiseh , Tajik Fatemeh 
Published: September 2022

Abstract

Introduction: Chronic lymphocytic leukemia (CLL) is defined by the presence of lymphocyte in the blood, bone marrow, lymph nodes, and spleen, with a median lymphocyte count of 20–30×109/L for more than three months. CLL is known to be rarely associated with myeloid malignancies. This study presents an extremely rare case of CLL, which transformed into myeloid /T neoplasm.Case presentation:A62-year-old man with a 10-year history of CLL was referred to our hospital because of multiple skin bruises and anemia. He was monitored for ten years without any treatment until this time when the disease progressed, and chemotherapy was started. After eight months of treatment completion, he deteriorated. This time, bone marrow biopsy immunophenotyping revealed the transformation of CLL into mixed phenotype acute leukemia, myeloid/T neoplasm with no residue of preexisting CLL.Conclusion:Transformation of CLL into acute leukemia may arise from the same clone. Still, there is some evidence that it may be therapy-related, so any deterioration in a patient with CLL should be evaluated promptly for a better outcome.
Analysis of the morphological characteristics and direction of morphology- based selective breeding of Procambarus clarkii
Authors: Wang Qishuai , Yang Siqi , Shi Ruixue , Zheng Feifei , Li Yanhe 
Published: September 2022

Abstract
In order to explore the breeding direction of morphological selection of Procambarus clarkii, the morphological characteristics of five P. clarkii basic populations from different regions in China were comprehensively analyzed by multivariate statistical analyses. The results showed that there were significant differences in most morphological parameters among populations and between sexes. In the discriminatory analysis, the most discriminant characteristics for distinguishing females among populations were body weight (BW), first abdominal segment width (FASW), third abdominal segment width (TASW) and third abdominal segment height (TASH), whereas for males, the characteristics were body weight (BW), carapace length (CL), carapace width (CW) and third abdominal segment width (TASW).The most significant variables of the differences between sexes were body weight (BW), third abdominal segment width (TASW) and double cheliped weight (DCW). This study would be beneficial to understanding the main morphological characteristics of P. clarkii, which could provide basic data of the collected germplasm resources and some reference for indicating the direction of P. clarkii morphology-based breeding. The germplasm resources with stronger abdomen, smaller carapace and smaller cheliped would be the selection targets, and all-female breeding would also be one of important breeding directions of for P. clarkii.
Causes for reforestation failure in Haiti and residents' willingness to pay for cleaner cookstoves
Authors: François Mathurin , Petit-Homme Ronald , Mariano-Neto Eduardo , Petit-Homme Marc Arthur , Junior Terencio Rebello de Aguiar 
Published: September 2022

Abstract
Trees provide services to human beings and protect the environment. This study investigates the causes of the failure of reforestation projects in the North and Northeast departments of Haiti. Two questionnaires with closed- and open-ended questions were used for face-to-face and semi-structured interviews with local and non-local authorities, respectively. The test of proportions was used for the statistical analysis, where a result was considered significant when the p-value was less than 0.05. The results showed that 86.8% of the non-local authorities were used to participating in projects of reforestation in their localities. The lack of follow-up and participation of residents in decisions about the type of trees planted were the main causes of the failure of these projects. The interviewees were accustomed to cutting trees to produce charcoal (95.8%) and enlarging their gardens (70.8%). However, 90.0% of each category would invest in purchasing cleaner cookstoves and stop using charcoal if the government agreed to finance up to 50.0% of such a project. The findings of this research could help both the decision-makers and the Haitian government to understand the causes of the failures of reforestation projects in Haiti and adopt an effective way to reduce deforestation in the country.
Willingness to pay for improved water supply service in coastal urban settings: evidence from Khulna, Bangladesh
Authors: Islam Md. Karimul , Akter Rabbani , Haider Mohammed Ziaul 
Published: September 2022

Abstract
The provision of clean water and sanitation has been one of the challenging targets of the Sustainable Development Goals (SDGs) for developing countries like Bangladesh. The southern cities of the country confront the scarcity of fresh and improved water for drinking and sanitation. The study aims to investigate the demand for improved water service among city dwellers and the potential revenue for the water supply authority. The study surveyed 100 households in Khulna city by administering a simple random sampling method. The single-bounded dichotomous choice contingent valuation method revealed that years of schooling, household income, and excessive time in water collection positively affect willingness to pay (WTP) for improved water service. The households are willing to pay US$ 5.05 per month on average for enjoying improved water service, which in turn produces annual revenues of US$ 4.26 million, overriding the current level of revenue by 2.5 times. Additionally, the water supply authority is incurring around US$ 2.14 million of revenue loss annually which can be recovered by supplying improved water to the city households. This study suggests that the government may be able to address the fresh and improved water scarcity in the urban territory by capturing and utilizing the potential revenue efficiently through removing the structural barriers.
Comprehensive application analyses of elastic models and viscoelastic models in transient flows in polymeric pipelines
Authors: Duan Xiangyu , Zhu Jianghui , Li Xiaoqin , Tang Xuelin 
Published: September 2022

Abstract
Based on the MOC (Method of Characteristics), the applicabilities of both the elastic models of the SF (Steady Friction), the CB-UF (Convolution-Based Unsteady Friction) and the MIAB-UF (Modified Instantaneous Acceleration-Based UF), and the viscoelastic models of the SF-VE (SF-Viscoelasticity), the CB-UF-VE (Convolution-Based Unsteady Friction-Viscoelasticity) and the MIAB-UF-VE (Modified Instantaneous Acceleration-Based UF-Viscoelasticity), are investigated for hydraulic transients induced by a downstream rapid valve closure in a polymeric pipeline. The predicted results by the elastic models are very different from the experimental data, whereas the predicted pressure peaks and phases by the viscoelastic models agree well with the experimental data because considering the pipe–wall creep effect, the CB-UF-VE and the MIAB-UF-VE generate better results than the SF-VE. The creep effects near the first pressure peak are captured well by the viscoelastic models. The analyses of the contributions of different factors to pressure attenuation show that for transient flows in polymeric pipelines, the effect of VE is greater than that of the CB-UF and MIAB-UF. The spectrum analyses show that the pressure amplitudes and harmonic frequencies by the elastic models match badly with the experimental data, whereas those by the viscoelastic models match well with the experimental data. The harmonic frequencies by the MIAB-UF-VE are the best, followed by the CB-UF-VE, and are worst by the SF-VE.
Neuroprotective Properties of Ferulic Acid in Preclinical Models of
Alzheimer’s Disease: A Systematic Literature Review
Authors: Zhou Siyu , Dong Xiaoyu 
Published: September 2022

Background:
Alzheimer's disease (AD) is one of the most common diseases in
the elderly, with a high incidence of dementia. The pathogenesis of AD is complex, and
there is no unified conclusion and effective treatment in the clinic. In recent years, with
the development of traditional Chinese medicine (TCM), researchers put forward the idea
of prevention and treatment of AD based on TCM according to the characteristics of multi-
target of TCM. Ferulic acid (FA), also known as 3-methoxy-4-hydroxycinnamic acid, is
an active ingredient in TCM that inhibits β-amyloid (Aβ) aggregation and has antioxidant
and anti-inflammatory effects. FA derivatives have been reported to have low toxicity,
high biological activity, and high blood-brain barrier permeability. However, the multitarget
of FA in the treatment of AD has not been systematically elucidated.

Objectives:
In this systematic review, we aimed to comprehensively assess the neuroprotective
effects of FA and its derivatives on in vitro and in vivo AD models.

Methods:
We searched PubMed, Chinese National Knowledge Infrastructure (CNKI), Baidu
Academic, and Wanfang databases for relevant pre-clinical studies until November 2021.

Results:
We identified studies that evaluated the efficacy of FA and its derivatives using
relevant keywords. 864 studies were included, of which 129 were found in PubMed, 111
in CNKI, 454 in Baidu Academic, and 170 in Wanfang. Due to duplication between databases,
and after applying the exclusion and inclusion criteria, 43 articles were selected.
Thereafter, the abstracts of the 43 articles were reviewed. Finally, 21 articles were included
in this review, including 11 in vivo, 5 in vitro, and 5 in vivo and in vitro studies.

Conclusion:
Previous studies have shown that FA or its derivatives have multiple therapeutic
effects on AD models and can improve the symptoms of AD and resistance of AD
cell models. FA and its derivatives have anti-Aβ aggregation, antioxidant, antiinflammatory,
and other effects and are potential drugs for the multi-targeted treatment of
AD. The result of our study showed that FA and its derivatives have significant therapeutic
effects on animal and cell models of AD, suggesting that they may be potential therapeutic
drugs for patients with AD.
Monoamine-oxidase Type B Inhibitors and Cognitive Functions in Parkinson’s
Disease: Beyond the Primary Mechanism of Action
Authors: Rinaldi Domiziana , Alborghetti Marika , Bianchini Edoardo , Sforza Michela , Galli Silvia , Pontieri Francesco E. 
Published: September 2022

:
Symptoms of cognitive impairment are rather common since the early stage of Parkinson’s
disease (PD); they aggravate with disease progression and may lead to dementia in a significant
proportion of cases. Worsening of cognitive symptoms in PD patients depends on the progression
of subcortical dopaminergic damage as well as the involvement of other brain neurotransmitter
systems in cortical and subcortical regions. Beyond the negative impact on disability and quality of
life, the presence and severity of cognitive symptoms may limit adjustments of dopamine replacement
therapy along the disease course.

:
This review focuses on the consequences of the administration of monoamine-oxidase type Binhibitors
(MAOB-I) on cognition in PD patients. Two drugs (selegiline and rasagiline) are available
for the treatment of motor symptoms of PD as monotherapy or in combination with L-DOPA or dopamine
agonists in stable and fluctuating patients; a further drug (safinamide) is usable in fluctuating
subjects solely.

:
The results of available studies indicate differential effects according to disease stage and drug features.
In early, non-fluctuating patients, selegiline and rasagiline ameliorated prefrontal executive
functions, similarly to other dopaminergic drugs. Benefit on some executive functions was maintained
in more advanced, fluctuating patients, despite the tendency of worsening prefrontal inhibitory
control activity. Interestingly, high-dose safinamide improved inhibitory control in fluctuating patients.
The benefit of high-dose safinamide on prefrontal inhibitory control mechanisms may stem
from its dual mechanism of action, allowing reduction of excessive glutamatergic transmission, in
turn secondary to increased cortical dopaminergic input.
Isolation and Characterization of Cellulose Nanofiber Obtained
From Agriculture Waste
Authors: Al Rashdi Shabib Sulaiman Ali , Patil Ganesh N. , Al Balushi Noura Ali Moosa , Manivannan Saravanan Ayaavu 
Published: September 2022

Background:
The fibers of date palm [DPFs] were used as a raw material to isolate cellulose nanofibers [CNFs] to assess their potential as reinforcements of composite materials in producing Bioplastic. The isolation of Nano cellulose [NCs] from DPF is still lacking, and the authors are not aware of any previous publication concerning the isolation of NCs from DPF.

Objective:
The date palm has huge potential in the application as a reinforcement agent to manufacture bio-nano composites and can be considered a renewable source of nanofibers with an etymology to agro-waste.

Method:
High-purity cellulose nanofibers were isolated from DPFs through an environmentally friendly treatment process that combined chemical [alkali & bleaching] and mechanical [ball milling].

Results:
A high yield of CNFs was successfully extracted, with 50% CNFs from overall DPFs. Scanning electron microscopy [SEM] results revealed the effects of isolation treatments on fiber morphology and showed long, loose nanofiber bundles with 8–100 nm in diameter. FTIR results showed that noncellulosic components were effectively removed. X-ray diffraction analysis revealed the improved crystallinity of the processed fibers with a high crystalline index of 69.78%.

Conclusion:
TGA results showed an enhancement in the thermal properties of the nanofibers. The removal of hemicellulose and lignin increased the crystallinity of the fibers, and the extracted CNFs were used in the synthesis of Bioplastic by using glycerol as a plasticizer and corn starch as a matrix using the casting method. The feasibility study proved that NC production is feasible in Oman and was successfully yielding cellulose nanofibers with potential in advanced applications. The availability of raw materials is sufficient to sustain the plan with a total capital investment of OMR 9,694,127, an operating cost of OMR 10,058,976, and a total annual net profit of OMR 2,235,445.926 which shows an ROI of 23%/year with a payback period of 4.34 years.