bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerating Digitalization in Healthcare with the InSilicoTrials Cloud-Based Platform: Four Use Cases
Authors: Nicolò Chiara , Sips Fianne , Vaghi Cristina , Baretta Alessia , Carbone Vincenzo , Emili Luca , Bursi Roberta 
Published: September 2022

AbstractThe use of in silico trials is expected to play an increasingly important role in the development and regulatory evaluation of new medical products. Among the advantages that in silico approaches offer, is that they permit testing of drug candidates and new medical devices using virtual patients or computational emulations of preclinical experiments, allowing to refine, reduce or even replace time-consuming and costly benchtop/in vitro/ex vivo experiments as well as the involvement of animals and humans in in vivo studies. To facilitate and widen the adoption of in silico trials, InSilicoTrials Technologies has developed a cloud-based platform, hosting healthcare simulation tools for different bench, preclinical and clinical evaluations, and for diverse disease areas. This paper discusses four use cases of in silico trials performed using the InSilicoTrials.com platform. The first application illustrates how in silico approaches can improve the early preclinical assessment of drug-induced cardiotoxicity risks. The second use case is a virtual reproduction of a bench test for the safety assessment of transcatheter heart valve substitutes. The third and fourth use cases are examples of virtual patients generation to evaluate treatment effects in multiple sclerosis and prostate cancer patients, respectively.
Participant Outcomes and Facilitator Experiences Following a Community Living Skills Program for Adult Mental Health Consumers
Authors: Sammells Eliza , Logan Alexandra , Sheppard Loretta 
Published: September 2022

AbstractOutcomes from participating in a six-week small-group living skills program, periodically implemented over two years with twelve adult mental health consumers, are reported as a case study. Occupational therapy and recovery-oriented approaches underpinned the development and implementation of the program thus it was important that outcome measures aligned with these perspectives. Data were gathered pre and post program using the Canadian Occupational Performance Measure (COPM) and the Life Skills Profile-16 (LSP-16) in each iteration of the program. Two occupational therapy program facilitators were interviewed about their experience of running the program and using these measurement tools. COPM occupational performance (p = 0.001) and COPM satisfaction (p = 0.004) scores indicated significant change at post-program whereas the LSP-16 total and subscale scores did not (p = 0.132 for total scores). Facilitator insights into the experience of implementing the living skills program and the perceived alignment of the COPM and LSP-16 with recovery-oriented practice are reported.
Mental Health First Aid Training with the Nepalese Community in Australia: An Evaluation of Effects on Knowledge, Confidence, Intentions, Willingness to have Contact and Stigmatizing Attitudes
Authors: Nepal Bharat , Khadka Gaurav , Jorm Anthony F , Simkhada Jyoti , Gauli Nirajan , Hall Neil 
Published: September 2022

AbstractThe aim of this study was to evaluate the effectiveness of Mental Health First Aid (MHFA) training amongst the Nepalese community in Australia by exploring the impact on knowledge about mental health first aid, confidence and intentions to help, willingness to have contact and stigmatizing attitudes towards people with mental illness. We hypothesized that since MHFA has been extensively evaluated with other communities and has been found to be effective, it would therefore be effective with this community as well. MHFA training was conducted by an accredited Nepalese-Australian MHFA Instructor with 162 participants from the Nepalese community in four states of Australia. Participants completed an evaluation questionnaire prior to the training (pre-test) and at the end of the training (post-test). The evaluation questionnaire assessed participants? knowledge about what was taught in the course, ability to recognize depression as described in a vignette, confidence in providing help, intentions to provide help, and willingness to have contact and stigmatizing attitudes towards people with mental illness. There were large improvements from pre-test to post-test in knowledge, confidence and intentions to help, medium improvements in willingness to have contact, small-to-medium improvements in stigmatizing attitudes and small improvements in recognition of depression. Participants gave high ratings of the course and the instructor. MHFA training produced improvements in knowledge, confidence, intentions, willingness to have contact and stigmatizing attitudes. The training was also well received. Further research is needed to assess persistence of these effects following the course and any changes in mental health first aid provided to the community.
Speeding up neural network robustness verification via algorithm configuration and an optimised mixed integer linear programming solver portfolio
Authors: König Matthias , Hoos Holger H. , Rijn Jan N. van 
Published: September 2022

AbstractDespite their great success in recent years, neural networks have been found to be vulnerable to adversarial attacks. These attacks are often based on slight perturbations of given inputs that cause them to be misclassified. Several methods have been proposed to formally prove robustness of a given network against such attacks. However, these methods typically give rise to high computational demands, which severely limit their scalability. Recent state-of-the-art approaches state the verification task as a minimisation problem, which is formulated and solved as a mixed-integer linear programming (MIP) problem. We extend this approach by leveraging automated algorithm configuration techniques and, more specifically, construct a portfolio of MIP solver configurations optimised for the neural network verification task. We test this approach on two recent, state-of-the-art MIP-based verification engines, $$\mathrm {MIPVerify}$$
MIPVerify
and $$\mathrm {Venus}$$
Venus
, and achieve substantial improvements in CPU time by average factors of up to 4.7 and 10.3, respectively.
A Cofactor-Based Mechanism for the Origin of the Genetic Code
Authors: Martínez Giménez Juan A. , Tabares Seisdedos Rafael 
Published: September 2022

AbstractThe origin of the genetic code is probably the central problem of the studies on the origin of life. The key question to answer is the molecular mechanism that allows the association of the amino acids with their triplet codons. We proposed that the codon-anticodon duplex located in the acceptor stem of primitive tRNAs would facilitate the chemical reactions required to synthesize cognate amino acids from simple amino acids (glycine, valine, and aspartic acid) linked to the 3′ acceptor end. In our view, various nucleotide-A-derived cofactors (with reactive chemical groups) may be attached to the codon-anticodon duplex, which allows group-transferring reactions from cofactors to simple amino acids, thereby producing the final amino acid. The nucleotide-A-derived cofactors could be incorporated into the RNA duplex (helix) by docking Adenosine (cofactor) into the minor groove via an interaction similar to the A-minor motif, forming a base triple between Adenosine and one complementary base pair of the duplex. Furthermore, we propose that this codon-anticodon duplex could initially catalyze a self-aminoacylation reaction with a simple amino acid. Therefore, the sequence of bases in the codon-anticodon duplex would determine the reactions that occurred during the formation of new amino acids for selective binding of nucleotide-A-derived cofactors.
Respektverlust. Zur Kritik an gewaltvoller Kommunikation
Authors: Kron Thomas , Verneuer-Emre Lena M. 
Published: September 2022

ZusammenfassungDer Beitrag reagiert auf die Kritik von Thomas Hoebel zu unserem Vorschlag, das Modell soziologischer Erklärung (MSE) für die Erklärung von Gewaltphänomenen einzusetzen. Dabei fokussiert er drei seiner Kritikpunkte: Erstens zeigt er, dass das MSE keine Begriffsfestlegung darüber liefert, was „Gewalt“ ist. Unser Vorschlag impliziert weder einen Begriffsrealismus noch eine Festlegung des Begriffs durch das MSE, dessen explanatorische Vorgehensweise Hoebel in seiner Kritik nicht vollständig berücksichtigt. Zweitens weist er den Vorwurf zurück, unsere Literaturauswahl sei ein selektives „Rosinenpicken“. Die von Hoebel als Gegenbeweise angeführten Studien widersprechen unserem Vorschlag nicht, sondern stützen diesen sogar. Drittens geht er auf Hoebels Fehlinterpretation unserer Übersetzung von Randall Collins’ Ansatz in das MSE ein: Seine Fehldeutung beruht auf einer voreiligen Gleichsetzung des MSE mit einem engen Verständnis von Rationaltheorien. Die Replik schließt mit einer Erklärung für die gewaltvoll kommunizierte Kritik von Hoebel.
Fabrication and characterization of ZnO/Se1-xTex solar cells
Authors: Zheng Jiajia , Fu Liuchong , He Yuming , Li Kanghua , Lu Yue , Xue Jiayou , Liu Yuxuan , Dong Chong , Chen Chao , Tang Jiang 
Published: September 2022

AbstractSelenium (Se) element is a promising light-harvesting material for solar cells because of the large absorption coefficient and prominent photoconductivity. However, the efficiency of Se solar cells has been stagnated for a long time owing to the suboptimal bandgap (> 1.8 eV) and the lack of a proper electron transport layer. In this work, we tune the bandgap of the absorber to the optimal value of Shockley–Queisser limit (1.36 eV) by alloying 30% Te with 70% Se. Simultaneously, ZnO electron transport layer is selected because of the proper band alignment, and the mild reaction at ZnO/Se0.7Te0.3 interface guarantees a good-quality heterojunction. Finally, a superior efficiency of 1.85% is achieved on ZnO/Se0.7Te0.3 solar cells.
Graphical abstract
Raman spectroscopy for microplastic detection in water sources: a systematic review
Authors: Chakraborty I. , Banik S. , Biswas R. , Yamamoto T. , Noothalapati H. , Mazumder N. 
Published: September 2022

AbstractThe increasing demand and use of plastics in our daily lives have caused an increase in microplastics (MPs) concentration in water bodies. Increasing MP in water affects aquatic life and is associated with several health issues. All sources of water whether fresh, marine, or sewage have reported the presence of various MPs. It is clear from relevant literature that the presence of MP with a particular chemical composition could be indicative of its source and could contribute to its removal. Increasing population density, plastic litters, fishing activities, and industrial wastes are major contributors of MP in water. This review is systematically undertaken where Raman spectroscopy (RS) is used as an indispensable tool to identify the chemical composition of the MP in various water sources (fresh/ground/drinking; ocean/sea; waste/sewage) between 2015 and 2021. Based on the Raman spectra, polystyrene (PS), polyethylene terephthalate (PET), polyethylene (PE), and polypropylene (PP) are some of the common MP identified in the water sources.
Influence of architectural space layout and building perimeter on the energy performance of buildings: A systematic literature review
Authors: Latha Harsha , Patil Shantharam , Kini Pradeep G. 
Published: September 2022

AbstractThe space layout is very essential in building design development and can significantly influence the energy performance of the built environment. Space layout design, which occurs during the early stages of scheme conception and design development, is one of the most important tasks in architectural design. This systematic literature review focused on the investigation of space layout and perimeter design variables on the energy performance of the buildings and the study of major energy performance indicators, such as lighting, ventilation, heating, and cooling load considering climatic factors. The Scopus database was used for a thorough investigation of the publications using space layout relevant keywords to study building energy performance. About 55 primary articles were assessed based on the impact of different variables concerned with space layout design mainly building perimeter variables on the energy performance of the building. From the review, we can conclude that by enhancing the perimeter design variables and spatial configuration substantial amount of energy can be saved. The orientation of the building, climate occupancy, and building form have a major role in the energy consumption investigation. According to the study, hospitals consumes more energy due to specific functional requirement than other buildings, and studies on the spatial configuration of the hospital is comparatively less where further studies can consider this issue along with the combination of multiple performance indicators. Well-configured space layout design may prevent unreasonable energy consumption and enhance the overall sustainability of the building and contribute to climate change mitigation.
Unbalanced, cracked, and misaligned rotating machines: a comparison between classification procedures throughout the steady-state operation
Authors: Rezazadeh Nima , De Luca Alessandro , Perfetto Donato 
Published: September 2022

AbstractThis article compares two intelligent methods for automatic detection of unbalancing, cracks, and parallel misalignment in rotary machines. The finite element method is used to model the faults in a rotating system. The modeled system then operates virtually under different conditions in the steady-state operation; the vibrational responses are calculated numerically. To compare the accuracy of different manners in the classification of defective systems, firstly, four distinct types of features, i.e., statistical, frequency, time–frequency, and uncertainty are exploited. The T test process is utilized to test the extracted characteristics; the unreliable features are removed from feature vectors, then the remained ones are used in four supervised machine learning classifiers, i.e., support vector machine, k-nearest neighbors, Naive Bayes, and decision trees. In the following, as the convolution neural networks (CNNs) approach, the persistence spectrums of raw signals are plotted, and these graphs are introduced as input data. Comparing results of the different classification methods, it has been observed that although CNNs based on persistence spectrum graphs are computationally heavy and time-consuming, they provide more accurate results than the other classifiers. The results show that the proposed approach for rotor fault detection is effective, accurate, and robust and that it has promise for real engineering applications.
Extended Reality-Assisted Surgery as a Surgical Training Tool: Pilot Study Presenting First HoloLens-Assisted Complex Penile Revision Surgery
Authors: Quesada-Olarte Jose , Carrion Rafael E. , Fernandez-Crespo Raul , Henry Gerad D. , Simhan Jay , Shridharani Anand , Carrion Rafael E. , Hakky Tariq S. 
Published: September 2022

ABSTRACT

Background
Extended reality-assisted urologic surgery (XRAS) is a novel technology that superimposes a computer-generated image on the physician’s field to integrate common elements of the surgical process in more advanced detail. An extended reality (XR) interface is generated using optical head-mounted display (OHMD) devices.

Aim
To present the first case of HoloLens-assisted complex penile revision surgery.

Methods
We describe our pilot study of HoloLens-assisted penile revision surgery and present a thorough review of the literature regarding XRAS technology and innovative OHMD devices.

Outcomes
The ability of XRAS technology to superimpose a computer-generated image of the patient and integrate common elements of the surgical planning process with long-distance experts.

Results
XRAS is a feasible technology for application in complex penile surgical planning processes.

Clinical Translation
XRAS and OHMD devices are novel technologies applicable to urological surgical training and planning.

Strengths and Limitations
Evidence suggests that the potential use of OHMD devices is safe and beneficial for surgeons. We intend to pioneer HoloLens technology in the surgical planning process of a malfunctioning penile implant due to herniation of the cylinder. This novel technology has not been used in prosthetic surgery, and current data about XRAS are limited.

Conclusion
OHMD devices are effective in the operative setting. Herein, we successfully demonstrated the integration of Microsoft HoloLens 2 into a penile surgical planning process for the first time. Further development and studies for this technology are necessary to better characterize the XRAS as a training and surgical planning tool.
Affective Capital: Lagos and Nigerian Music Videos
Authors: Eromosele Femi 
Published: September 2022

AbstractLagos is a recurrent theme in Nigerian music videos. Eromosele examines this phenomenon in relation to the objectives of the music video and the musician’s star image. Various studies involving emotion and forms of capital help to reveal how Lagos is appropriated into the iconography of music stars in ways that extend the city’s affective capital while serving the promotional aims of the music video. Capital is viewed chiefly as value accumulated through circulation and capable of being transubstantiated into different forms. The economic and political prominence of Lagos influences and is fed by the city’s affective power.
Fires, floods and other extreme events – How watershed processes under climate change will shape our coastlines
Authors: Warrick Jonathan A. , East Amy E. , Dow Helen 
Published: September 2022

AbstractOngoing sea-level rise has brought renewed focus on terrestrial sediment supply to the coast because of its strong influence on whether and how long beaches, marshes and other coastal landforms may persist into the future. Here, we summarise findings of sediment discharge from several coastal rivers, revealing that infrequent, large-magnitude events have disproportionate influence on the morphodynamics of coastal landforms and littoral cells. These event-dominated effects are most pronounced for small, steep mountainous rivers that supply beach and wetland sediment along the world’s active tectonic margins, although infrequent events are important drivers of sediment discharge for rivers worldwide. Additionally, extreme events (recurrence intervals of decades to centuries) that follow wildfires, earthquakes, volcanic eruptions, extreme precipitation or – most notably – combinations of these factors can redefine coastal sediment budgets and morphology. Some of these extreme events (e.g., wildfiresplusrainfall) are increasing in magnitude and frequency under modern climate warming, with the likely result of increasing sediment flux to affected coastlines. Climate change is also altering watershed processes in both high latitudes and high altitudes, resulting in increased sediment supply to downstream catchments. We conclude that sediment inputs to coastal systems are highly variable with time, and that the variability and trends in sediment input are as important to characterise as long-term averages.
Patient-level information underlying overdiagnosis of urinary tract infections in nursing homes: A discrete choice experiment
Authors: Wretman Christopher J. , Boynton Marcella H. , Preisser John S. , Zimmerman Sheryl , Kistler Christine E. 
Published: September 2022

AbstractThe overdiagnosis of urinary tract infections (UTIs) in nursing home residents is a significant public health threat. Using a discrete choice experiment and a diagnostic guideline, we examined which patient-level information was associated with the overdiagnosis of UTIs and found that urinalysis results and lower urinary tract status were most associated.
Die Weinstockrede Jesu und die missionstheologische Relevanz der gegenseitigen Liebe (Joh 15.1–17)
Authors: Hentschel Anni 
Published: September 2022

AbstractThe Johannine commandment of love aims not only in an ethical-ecclesial sense at the cohesion in the church, but in a mission-theological sense at the winning of new church members. Jn 15.1–17 explains how the mutual immanence of God, Jesus and his disciples enables his followers to gain new fruit in the sense of new church members through mutual love. This continues the christological-ecclesial interpretation of Jesus’ foot-washing from John 13. The symbolic action illustrates how Jesus’ mission leads to the foundation of a community of disciples as a community of love, which becomes the place where the love of God can be permanently experienced (13.1–20, 34–5). The disciples are commissioned to make love present in the world. They are equal among themselves in their immediacy to Jesus, as members of the community of discipleship. A mission-theological use of the harvest metaphor is already found prominently in John 4.35–8 and 12.24–6 and thus in two texts, each of which describes the mission of the followers in correspondence to the mission of Jesus. The vine metaphor deepens that and how Jesus’ followers are to contribute to the enlargement of the community of followers even after his departure, whereby the pre-Easter community of followers is the model for the post-Easter community.
Metaleptisches Erzählen und kulturelles Gedächtnis in den Paulusakten
Authors: Kirchner Markus 
Published: September 2022

AbstractThe Acts of Paul have received the most diverse and contradictory interpretations. Do the ActPl intend to promote the veneration of Paul or a particular theology? Do they offer transparent fiction or do they claim factuality? Are they a collection of oral traditions or a designed literary construction? From the perspective of cultural memory theory, however, the key question is rather how the text allows the reader to participate in a community-generating past. In this view, the opposites turn out to be complementary aspects of an integrative textual strategy. This becomes manifest especially in the technique of metaleptic narration, which transcends the boundary between the world of the text and the reader, between past and present.
Stretching the Scope of Salvation in Matthew: The Significance of the Great Peter's Failings
Authors: Henning Bruce 
Published: September 2022

AbstractMatthew's didactic teaching blocks often present the terms of salvation as an uncompromising dichotomy, envisioning either complete loyalty or faithlessness (e.g. 10.37–9; 16.25; 24.13). However, the characters in his narrative sections, especially Peter, nuance this harsh binary to allow for a significant degree of failure. After a brief survey recent works on Matthean soteriology and the use of Peter, it is argued that two features of Peter, when combined, widen the scope of salvation. First, Matthew portrays him as occupying a ‘middle ground’ between complete obedience and absolute failure, with all indications pointing to Peter remaining in that space, as emphasised by the last references to him (27.25; 28.16). Second, this failing Peter will not only be allowed in the kingdom, but will have a position of greatness there, as demonstrated by both Matthew's overall theology of status variation within the kingdom (e.g. 19.28; 20.26–7; 5.19) and his unique Petrine accounts (14.22–33; 16.17–19; 17.24–7). Though the way to salvation is narrow (i.e. 7.14), the character of Peter widens it to allow for more failure than some texts in the didactic sections might initially suggest.