bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effective human–AI work design for collaborative decision-making
Authors: Jain Ruchika , Garg Naval , Khera Shikha N. 
Published: July 2022

PurposeWith the increase in the adoption of artificial intelligence (AI)-based decision-making, organizations are facilitating human–AI collaboration. This collaboration can occur in a variety of configurations with the division of labor, with differences in the nature of interdependence being parallel or sequential, along with or without the presence of specialization. This study intends to explore the extent to which humans express comfort with different models human–AI collaboration.Design/methodology/approachSituational response surveys were adopted to identify configurations where humans experience the greatest trust, role clarity and preferred feedback style. Regression analysis was used to analyze the results.FindingsSome configurations contribute to greater trust and role clarity with AI as a colleague. There is no configuration in which AI as a colleague produces lower trust than humans. At the same time, the human distrust in AI may be less about human vs AI and more about the division of labor in which human–AI work.Practical implicationsThe study explores the extent to which humans express comfort with different models of an algorithm as partners. It focuses on work design and the division of labor between humans and AI. The finding of the study emphasizes the role of work design in human–AI collaboration. There is human–AI work design that should be avoided as they reduce trust. Organizations need to be cautious in considering the impact of design on building trust and gaining acceptance with technology.Originality/valueThe paper's originality lies in focusing on the design of collaboration rather than on performance of the team.
The therapeutic effects and mechanisms of action of resveratrol on polycystic ovary syndrome: A comprehensive systematic review of clinical, animal and in vitro studies
Authors: Karimi Arash , Tutunchi Helda , Naeini Fatemeh , Vajdi Mahdi , Mobasseri Majid , Najafipour Farzad 
Published: July 2022

AbstractPolycystic ovary syndrome (PCOS) is one of the most important and common polygenic endocrine disorders among women of reproductive age. Resveratrol, a natural phenol, is involved in various biological activities, including antioxidant, antiseptic, anti‐inflammatory, anti‐ageing and anti‐cancer effects. This systematic review aimed to investigate the therapeutic effects and mechanisms of actions of resveratrol in PCOS. The present study was conducted according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta‐Analysis statements. We searched PubMed, Science Direct, Google Scholar, Scopus, ISI Web of Science, ProQuest and Embase databases up to August 2021 by using the relative keywords. Original studies published in the English language that assessed the effects of resveratrol on PCOS and its associated complications were considered. Out of 417 records screened, only 24 articles met the inclusion criteria: 10 in vitro, 10 animal and 4 human studies. The results obtained in the present study showed that resveratrol supplementation might be effective in improving PCOS‐related symptoms by reducing insulin resistance, alleviating dyslipidaemia, improving ovarian morphology and anthropometric indices, regulating the reproductive hormones and reducing inflammation and oxidative stress by affecting biological pathways. According to the available evidence, resveratrol may reduce the complications of PCOS. However, further studies are recommended for a comprehensive conclusion on the exact mechanism of resveratrol in PCOS patients.
A cogwheel model of dynamic capabilities: Evidence from an Australian university
Authors: Hube Benita , Stockport Gary , Soutar Geoffrey 
Published: July 2022

AbstractThe Australian tertiary education sector has been experiencing transformational change for many years driven by shifts in public policy and funding, emergent competition on an increasingly international scale, a seemingly never‐ending number of universities restructures, and the sudden rise of online teaching forced upon by the global COVID‐19 pandemic. This high level of environmental uncertainty suggests that if universities want to remain competitive, they might need to reconsider their strategies through adopting a dynamic capabilities (DCs) approach, such as outlined in this paper. This research is built on Teece et al.’s DCs model to examine an Australian university between 2012 and 2021. This research adds to our understanding of DCs by developing a metaphorical Cogwheel Model of Dynamic Capabilities that captures DCs’ complex and dynamic process. This model has implications for leadership and managerial practices, especially when organisations seek to navigate a strategic pathway into the future.
eDNAssay: A machine learning tool that accurately predicts qPCR cross‐amplification
Authors: Kronenberger John A. , Wilcox Taylor M. , Mason Daniel H. , Franklin Thomas W. , McKelvey Kevin S. , Young Michael K. , Schwartz Michael K. 
Published: July 2022

AbstractEnvironmental DNA (eDNA) sampling is a highly sensitive and cost‐effective technique for wildlife monitoring, notably through the use of qPCR assays. However, it can be difficult to ensure assay specificity when many closely related species co‐occur. In theory, specificity may be assessed in silico by determining whether assay oligonucleotides have enough base‐pair mismatches with nontarget sequences to preclude amplification. However, the mismatch qualities required are poorly understood, making in silico assessments difficult and often necessitating extensive in vitro testing—typically the greatest bottleneck in assay development. Increasing the accuracy of in silico assessments would therefore streamline the assay development process. In this study, we paired 10 qPCR assays with 82 synthetic gene fragments for 530 specificity tests using SYBR Green intercalating dye (n = 262) and TaqMan hydrolysis probes (n = 268). Test results were used to train random forest classifiers to predict amplification. The primer‐only model (SYBR Green results) and full‐assay model (TaqMan probe‐based results) were 99.6% and 100% accurate, respectively, in cross‐validation. We further assessed model performance using six independent assays not used in model training. In these tests the primer‐only model was 92.4% accurate (n = 119) and the full‐assay model was 96.5% accurate (n = 144). The high performance achieved by these models makes it possible for eDNA practitioners to more quickly and confidently develop assays specific to the intended target. Practitioners can access the full‐assay model online via eDNAssay (https://NationalGenomicsCenter.shinyapps.io/eDNAssay), a user‐friendly tool for predicting qPCR cross‐amplification.
Impacts of Depositional Facies and Diagenesis on Reservoir Quality: A Case Study from the Rudist‐bearing Sarvak Formation, Abadan Plain, SW Iran
Authors: ASSADI Ali , HONARMAND Javad , MOALLEMI Seyed Ali , ABDOLLAHIE‐FARD Iraj 
Published: July 2022

AbstractAn integrated geological‐petrophysical analysis of the rudist‐bearing sequence of the Cretaceous Sarvak Formation is given one giant oilfield, and provides an improved understanding of this main reservoir in the Abadan Plain, in the Zagros Basin, SW Iran. The main objective of this study is to evaluate reservoir potential of the Sarvak Formation, and then to utilize the calibrated well log signature to correlate reservoir potential in un‐cored wells. Eight main facies are recognized and categorized in five facies groups: lagoon, shoal, rudist‐biostrome, slope, and shallow open marine, deposited on a shelf carbonate platform. Given the distribution of diagenetic products and their effects on pore systems, three diagenetic facies namely, (DF‐1) low dissolution and cementation; (DF‐2); high dissolution; and (DF‐3) high cementation are differentiated. The initial sedimentary characteristics in combination with distribution of diagenetic products play an important role in reservoir quality heterogeneity. The effect of diagenetic processes related to disconformities mainly depends on the facies nature below these surfaces. Grain‐dominated facies of shoal and rudist debris, observed below the Cenomanian–Turonian disconformity, are mostly characterized by high dissolution and interconnected pore systems. Finally, depositional and diagenetic facies in the studied wells are correlated by petrophysical well log data, leading to distribution of the reservoir zones. Data obtained can be utilized for efficient reservoir characterization of the Sarvak Formation and its equivalent units in the Arabian Plate.
Depositional Environment and Lithofacies Analyses of Eocene Lacustrine Shale in the Bohai Bay Basin: Insights from Mineralogy and Elemental Geochemistry
Authors: KHAN Danish , LIANG Chao , QIU Longwei , Kamran MIRZA , WANG Yelei , KASHIF Muhammad , REHMAN Saif Ur , WANG Yuzhe , TENG Jianbin 
Published: July 2022

AbstractThe effect of various depositional parameters including paleoclimate, paleosalinity and provenance, on the depositional mechanism of lacustrine shale is very important in reconstructing the depositional environment. The classification of shale lithofacies and the interpretation of shale depositional environment are key features used in shale oil and gas exploration and development activity. The lower 3rd member of the Eocene Shahejie Formation (Es3x shale) was selected for this study, as one of the main prospective intervals for shale oil exploration and development in the intracratonic Bohai Bay Basin. Mineralogically, it is composed of quartz (avg. 9.6%), calcite (avg. 58.5%), dolomite (avg. 7%), pyrite (avg. 3.3%) and clay minerals (avg. 20%). An advanced methodology (thin‐section petrography, total organic carbon and total organic sulfur contents analysis, X‐ray diffraction (XRD), X‐ray fluorescence (XRF), field‐emission scanning electron microscopy (FE‐SEM)) was adopted to establish shale lithofacies and to interpret the depositional environment in the lacustrine basin. Six different types of lithofacies were recognized, based on mineral composition, total organic carbon (TOC) content and sedimentary structures. Various inorganic geochemical proxies (Rb/Sr, Ca/(Ca + Fe), Ti/Al, Al/Ca, Al/Ti, Zr/Rb) have been used to interpret and screen variations in depositional environmental parameters during the deposition of the Es3x shale. The experimental results indicate that the environment during the deposition of the Es3x shale was warm and humid with heightened salinities, moderate to limited detrital input, higher paleohydrodynamic settings and strong oxygen deficient (reducing) conditions. A comprehensive depositional model of the lacustrine shale was developed. The interpretations deduced from this research work are expected to not only expand the knowledge of shale lithofacies classification for lacustrine fine‐grained rocks, but can also offer a theoretical foundation for lacustrine shale oil exploration and development.
Disease monitoring of epidermal growth factor receptor (EGFR)‐mutated non‐small‐cell lung cancer patients treated with tyrosine kinase inhibitors via EGFR status in circulating tumor DNA
Authors: Li Yan , Xu Ziyi , Wang Shouzheng , Zhu Yixiang , Ma Di , Mu Yuxin , Ying Jianming , Li Junling , Xing Puyuan 
Published: July 2022

AbstractObjectiveCirculating tumor DNA (ctDNA) monitoring proves to be a promising approach to assess response and predict survival in epidermal growth factor receptor (EGFR)‐mutated non‐small‐cell lung cancer (NSCLC) patients treated with tyrosine kinase inhibitors (TKIs). However, whether the dynamic changes in ctDNA EGFR mutation status have the same predictive value as ctDNA remains unknown. This study aims to explore the predictive value of dynamic changes in both ctDNA and ctDNA EGFR status.MethodsA retrospective analysis was performed using 91 ctDNA samples from a cohort of 28 patients who were diagnosed with EGFR‐mutated NSCLC and treated with EGFR‐TKIs, including 14 patients treated with first‐/second‐generation TKIs and 14 treated with osimertinib. Blood samples at baseline (BL), within 4 weeks after TKI initiation (Week4), within 12 weeks before progression (pre‐PD), and at progression were collected. The relationship alternatives in ctDNA status, ctDNA EGFR status and response to EGFR‐TKIs as well as progression‐free survival (PFS) were analyzed.ResultsWe categorized 20 BL‐ctDNA positive patients with available Week4‐ctDNA into two groups: ctDNA‐clearance (N = 7, 35%) and ctDNA‐non‐clearance (N = 13, 65%). The ctDNA‐clearance group had better PFS than the ctDNA‐non‐clearance group (ctDNA‐clearance vs. ctDNA‐non‐clearance, p = 0.091, hazard ratio [HR] = 0.42, 95% confidence interval [CI] = 0.15–1.19). According to Week4‐EGFR status, we observed that PFS was significantly longer in EGFR‐clearance patients than EGFR‐non‐clearance groups, (p = 0.011, HR = 0.23, 95% CI = 0.08–0.72). We then categorized patients into three subgroups according to Week4‐ctDNA and Week4‐EGFR status: non‐clearance (N = 9), only‐EGFR‐clearance (concomitant alterations non‐clearance) (N = 4), and all‐clearance (N = 7). The nonclearance group had a significantly worse PFS than the all‐clearance group (median PFS = 5.07 vs. 11.40 months, p = 0.029, HR = 3.45, 95% CI = 1.05–11.49). The only‐EGFR‐clearance group had a similar PFS to the all‐clearance group (p = 0.607), which was longer than that of the non‐clearance group (median PFS = 9.20 vs. 5.07 months, p = 0.060, HR = 0.25, 95% CI = 0.05–1.18). We found that the all‐clearance group had a similar objective response rate (ORR) to the only‐EGFR‐clearance group (p = 1.000) and a higher ORR than the non‐clearance group (p = 0.012).ConclusionMonitoring of EGFR clearance in ctDNA is promising and cost‐effective in assessing response and predicting survival in EGFR‐mutated NSCLC patients treated with EGFR‐TKIs, with similar predictive value to ctDNA surveillance.
SMARCA4‐deficient undifferentiated tumor that responded to chemotherapy in combination with immune checkpoint inhibitors: A case report
Authors: Utsumi Takahiro , Taniguchi Yohei , Noda Yuri , Fukai Mari , Kibata Kayoko , Murakawa Tomohiro 
Published: July 2022

AbstractThoracic SMARCA4‐deficient undifferentiated tumors are a new type of neoplasm that commonly occur in the mediastinum, progress rapidly, and show a poorer prognosis. We report a case of thoracic SMARCA4‐deficient undifferentiated tumor in the right thoracic cavity in a patient with a history of heavy smoking and presenting with respiratory distress and hemoptysis. Imaging showed pleural effusion and thickening. A diagnostic right pleural biopsy yielded multiple white nodules and pale bloody pleural effusion accumulated in the right thoracic cavity. Histopathologically, the tumor cells were large, some exhibited rhabdoid cytology, and they were surrounded by an infiltration of inflammatory cells. These tumor cells were negative for SMARCA4, p40, NUT, and claudin‐4, leading to establishing a diagnosis of thoracic SMARCA4‐deficient undifferentiated malignancy. We treated the patient with atezolizumab, carboplatin, and nab‐paclitaxel. The patient achieved stable disease at 7 months during this study. Although there is no standard treatment of this disease, our reported treatment may contribute to improved prognosis, requiring further research.
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis
Authors: D'Amico Davide , Olmer Merissa , Fouassier Andréane M. , Valdés Pamela , Andreux Pénélope A. , Rinsch Chris , Lotz Martin 
Published: July 2022

AbstractOsteoarthritis (OA) is the most common age‐related joint disorder with no effective therapy. According to the World Health Organization, OA affects over 500 million people and is characterized by degradation of cartilage and other joint tissues, severe pain, and impaired mobility. Mitochondrial dysfunction contributes to OA pathology. However, interventions to rescue mitochondrial defects in human OA are not available. Urolithin A (Mitopure) is a natural postbiotic compound that promotes mitophagy and mitochondrial function and beneficially impacts muscle health in preclinical models of aging and in elderly and middle‐aged humans. Here, we showed that Urolithin A improved mitophagy and mitochondrial respiration in primary chondrocytes from joints of both healthy donors and OA patients. Furthermore, Urolithin A reduced disease progression in a mouse model of OA, decreasing cartilage degeneration, synovial inflammation, and pain. These improvements were associated with increased mitophagy and mitochondrial content, in joints of OA mice. These findings indicate that UA promotes joint mitochondrial health, alleviates OA pathology, and supports Urolithin A's potential to improve mobility with beneficial effects on structural damage in joints.
Human age reversal: Fact or fiction?
Authors: Johnson Adiv A. , English Bradley W. , Shokhirev Maxim N. , Sinclair David A. , Cuellar Trinna L. 
Published: July 2022

AbstractAlthough chronological age correlates with various age‐related diseases and conditions, it does not adequately reflect an individual's functional capacity, well‐being, or mortality risk. In contrast, biological age provides information about overall health and indicates how rapidly or slowly a person is aging. Estimates of biological age are thought to be provided by aging clocks, which are computational models (e.g., elastic net) that use a set of inputs (e.g., DNA methylation sites) to make a prediction. In the past decade, aging clock studies have shown that several age‐related diseases, social variables, and mental health conditions associate with an increase in predicted biological age relative to chronological age. This phenomenon of age acceleration is linked to a higher risk of premature mortality. More recent research has demonstrated that predicted biological age is sensitive to specific interventions. Human trials have reported that caloric restriction, a plant‐based diet, lifestyle changes involving exercise, a drug regime including metformin, and vitamin D3 supplementation are all capable of slowing down or reversing an aging clock. Non‐interventional studies have connected high‐quality sleep, physical activity, a healthy diet, and other factors to age deceleration. Specific molecules have been associated with the reduction or reversal of predicted biological age, such as the antihypertensive drug doxazosin or the metabolite alpha‐ketoglutarate. Although rigorous clinical trials are needed to validate these initial findings, existing data suggest that aging clocks are malleable in humans. Additional research is warranted to better understand these computational models and the clinical significance of lowering or reversing their outputs.
Effect of intermittent access to alcohol mixed in energy drink during adolescence on alcohol self‐administration, anxiety, and memory during adulthood in rats
Authors: Williams Keith L. , Parikh Urja K. , Doyle Shannon M. , Meyer Lindsey N. 
Published: July 2022

AbstractBackgroundMixing alcohol with caffeinated energy drinks is a common practice among young people. Consumption of alcohol mixed in energy drink is associated with increased risk of binge drinking and alcohol dependence. The purpose of this study was to determine whether voluntary intermittent access to alcohol mixed in energy drink in adolescent rats alters adult self‐administration of alcohol, anxiety, and memory.MethodsFor 10 weeks in the home‐cage, two groups of adolescent female Sprague–Dawley rats had intermittent access to energy drink (ED) or 10% alcohol mixed in energy drink (AmED) with water concurrently available. Other rat groups had daily continuous access to ED or AmED. Anxiety was measured with an open field test and memory was assessed with a novel place recognition test. For self‐administration, rats pressed levers for 10% alcohol alone on a fixed ratio (FR1) and on a progressive ratio (PR).ResultsIntermittent access to AmED generated greater intake during the initial 30 min of access (AmED 1.70 ± 0.04 g/kg vs. ED 1.01 ± 0.06 g/kg) and during the subsequent 24 h (AmED 7.04 ± 0.25 g/kg vs. ED 5.60 ± 0.29 g/kg). Intermittent AmED caused a significant but small decrease in anxiety while neither ED nor AmED altered memory. During alcohol self‐administration, group differences emerged only during PR testing during which intermittent AmED rats responded more than all other groups.ConclusionsThese findings suggest that intermittent access to AmED generates binge‐like consumption that supports human findings that AmED generates greater alcohol consumption. Furthermore, experience with AmED may alter the motivational properties of alcohol into adulthood without necessarily causing a major impact on anxiety or memory.
Does short sales deregulation affect qualitative information disclosure?
Authors: He Jie , Chan Kam C. 
Published: July 2022

AbstractWe examine the impact of short sales deregulation on firms' disclosure of non‐financial qualitative information. Our simple analytical model predicts that, after short sales deregulation and when the cost of disclosing proprietary qualitative information to the firm and its executives is sufficiently high, shortable firms respond by disclosing less proprietary and more non‐proprietary qualitative information than non‐shortable firms. Using a textual analysis of qualitative information about the supply chain, available in the management disclosure and analysis sections of the annual reports of a sample of Chinese firms, and applying a staggered difference‐in‐differences research design, we find evidence consistent with the model's prediction.
A systematic review and meta‐analysis of treatments for rapid cycling bipolar disorder
Authors: Strawbridge Rebecca , Kurana Suman , Kerr‐Gaffney Jess , Jauhar Sameer , Kaufman Kenneth R. , Yalin Nefize , Young Allan H. 
Published: July 2022

AbstractObjectivesRapid cycling is a common and disabling phenomenon in individuals with bipolar disorders. In the absence of a recent literature examination, this systematic review and meta‐analysis aimed to synthesise the evidence of efficacy, acceptability and tolerability of treatments for individuals with rapid cycling bipolar disorder (RCBD).MethodA systematic search was conducted to identify randomised controlled trials assigning participants with RCBD to pharmacological and/or non‐pharmacological interventions. Study inclusion and data extraction were undertaken by two reviewers independently. The primary outcome was continuous within‐subject RCBD illness severity before and after treatment. Pre‐post random effects meta‐analyses were conducted for each outcome/intervention arm studied, generating a standardised effect size (hedge's g) and 95% confidence interval (CI).ResultsA total of 34 articles describing 30 studies were included. A total of 16 separate pharmacological treatments were examined in contrast to 1 psychological therapy study. Only quetiapine and lamotrigine were assessed in >5 studies. By assessing 95% CI overlap of within‐subject efficacy effects compared to placebo, the only interventions suggesting significant depression benefits (placebo g = 0.60) were olanzapine (with/without fluoxetine; g = 1.01), citalopram (g = 1.10) and venlafaxine (g = 2.48). For mania, benefits were indicated for quetiapine (g = 1.01), olanzapine (g = 1.19) and aripiprazole (g = 1.09), versus placebo (g = 0.33). Most of these effect sizes were from only one trial per treatment. Heterogeneity between studies was variable, and 20% were rated to have a high risk of bias.ConclusionsWhile many interventions appeared efficacious, there was a lack of robust evidence for most treatments. Given the limited and heterogeneous evidence base, the optimal treatment strategies for people with RCBD are yet to be established.