bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is Sedentary Lifestyle Increasing the Risk of Obesity in Urban Adult Academic Professionals? An Epidemiological Study in West Bengal, India
Authors: Ghosh Sunandini , Paul Manabi , Mondal Kousik Kumar , Bhattacharjee Sandip , Bhattacharjee Pritha 
Published: September 2022

Abstract
Background: Ectopic fat deposition is more strongly associated with obesity related health problems including T2DM, CVD, thyroidism, arthritis etc. Objectives: Our study aimed at identifying the cumulative role of several risk factors in developing obesity and the role of ectopic fat (visceral fat) in predicting the cardiovascular disease risk in varied age groups among urban adult academic professionals in West Bengal. Methods: 650 adults (Male= 456; Female=194) associated with academic job (age 20-65 years) in urban West Bengal were randomly selected for anthropometric, blood biochemical and questionnaire-based analyses. Result: Body Mass Index and Visceral Fat% exhibited comparable association with all the other anthropometric parameters (e.g. Whole body Subcutaneous fat%: male- Linear Regression Comparison: F= 11.68; P<0.001; female- F= 6.11; P<0.01). Therefore, VF% acts as a risk factor alongside BMI in instances where BMI fails alone. Presence of T2DM, hypertension and thyroidism in the case groups confirmed their obesity associated longitudinal pattern of inheritance. Unhealthy diet pattern indicates improper liver functioning, vitamin D deficiency and increased erythrocytic inflammation. Conclusion: An overall sedentary lifestyle with parental history of obesity was found to be significant in the longitudinal transmission of the disease.
Differential flow velocities control method for push-bending of the thin-walled tube with a 0.9D bending radius by differential lubrication
Authors: Tao Ruichen , Xu Xuefeng , Fan Yubin , Xiao Jie , Wang Yanqi , Wei Liming 
Published: September 2022

Abstract
The smaller the relative bending radius of the bent tube, the more difficult the tube blank is to be bent. In this paper, the push-bending process for the aluminum tube with a relative bending radius of 0.9D was analyzed through simulation. There was tangential tensile stress concentration occurring at the front endpoint of tube intrados, which increased the risk of cracking. That is because the bending tube’s extrados moves less angular distance than its intrados by the uniform lubrication method, causing excessive deformation of the cross-section. Therefore, a differential lubrication method using the lubricant with a larger friction coefficient at intrados and the lubricant with a smaller friction coefficient at extrados was proposed to increase the angular velocity of the tube’s extrados. It was found that the differential lubrication method helped avoid excessive thinning at the front endpoint of tube intrados through simulations. Furthermore, push-bending experiments of 5A02 aluminum alloy with a relative bending radius of 0.9D were carried out to investigate this effect. The experimental results showed that the differential lubrication method effectively avoided cracking, which agreed with the simulation results.
A Comparison of Laparoscopic Pancreaticoduodenectomy and Open Pancreaticoduodenectomy at different stages of Learning curves：A single center report
Authors: Wang Shupeng , Li Lin , Liu Yahui 
Published: September 2022

Abstract
Background: With the advancement of surgical instruments and the growth of professional expertise over the last decade,laparoscopic pancreaticoduodenectomy(LPD) was widely applied in different centers.However, there are still some controversies about the safety of LPD.Hospital size, solid professional working experience,and the learning curve all have an impact on perioperative outcomes.In this study,our aim is to compare the outcomes at different stages of learning curve for LPD with open pancreatoduodenectomy(OPD).
Methods: We retrospectively analyzed the clinical datas of 911 patients who received PD at a single institution.Among them,208 patients underwent OPD and 703 cases were performed LPD successfully. According to the key point of the learning curve for LPD,we divided those patients into three phases,and compared the perioperative outcomes with OPD at different phases.
Result: In the initial stage,the incidence of complications and mortality related with LPD were significantly higher than those in OPD group,and the number of harvested lymph nodes,R0 resection rate were were similar with OPD group. Postoperative complications, operative time and intraoperative blood loss were significantly reduced with improved surgical experience. At the mature stage of learning curve, the incidence of postoperative complications in LPD was lower than in OPD group.Simultaneously, the length of hospital stay was substantially reduced and statistical considerably shorter than in the OPD group.
Conclusion: After a long period of training and learning, LPD can be performed safely.Meanwhile,after the surgeons have surmounted the learning curve,compared with OPD, LPD can achieve similar oncology results,lower the incidence of postoperative complications as well as faster the postoperative recovery.
Logistic regression technique is comparable to machine learning algorithms in predicting cognitive impairment related to post intensive care syndrome
Authors: Wu TingTing , Wei YueQing , Wu JingBing , Yi BiLan , Li Hong 
Published: September 2022

Abstract
Objective: The aim of this study was to explore whether machine learning (ML) algorithms are more accurate than traditional statistical models in predicting cognitive impairment related to post intensive care syndrome (PICS-CI).
Research Methodology: We conducted a prospective observational study of ICU patients at two tertiary hospitals. A cohort of 2079 patients was screened, and finally 481 patients were included. Six different ML models were considered, decision tree (DT), random forest (RF), XGBoost, neural network (NN), naïve Bayes (NB), and support vector machine (SVM), and compared with logistic regression (LR). Discriminative ability was evaluated by area under the receiver operating characteristic curve (AUC), calibration belt plots, and Hosmer-Lemeshow test was used to assess calibration. Decision curve analysis was performed to quantify clinical utility.
Results: All ML models showed good performance (AUC range: 0.822–0.906). NN model had the highest AUC (0.906 [95%CI: 0.857–0.955]), which was slightly higher than, but not significantly different from that of LR (0.898 [95%CI: 0.847–0.949]) (P>0.05, Delong test). Except for DT, XBGoost, and NB models, the other ML models demonstrated good agreement between the predicted and observed probability of PICS-CI (Hosmer and Lemeshow Test, P>0.05). Decision curve analysis showed higher net benefit of most of the ML models. Given the overfitting and complexity of some ML models, the LR model was then used to develop a web-based risk calculator to aid decision-making (https://model871010.shinyapps.io/dynnomapp/).
Conclusion: In a low dimensional data, logistic regression may yield as good performance as ML models to predict cognitive impairment after ICU hospitalization.
A Secured Reversible Data Hiding Technique for Multiple Secrets using Image Interpolation with Bit Reversal Permutation
Authors: Jana Manasi , Jana Biswapati , Lu Tzu-Chuen , Pal Pabitra , Jana Sharmistha , Joardar Subhankar 
Published: September 2022

Abstract
Early interpolation based data hiding methods embed one secret information with lower hiding capacity and suffer visual distortion with security loophole caused by the hidden message embedding. In this paper, we have proposed a secured high capacity reversible data hiding technique for multiple secrets using image interpolation with bit reversal permutation to overcome the said problem. Multiple secret messages are encrypted using bit reversal permutation before embedding within cover image to make it more robust and secure. Here, we proposed a mechanism which divides a fixed length sub-message into two values for each (4 × 4) overlapping block. Then one value is added and another is subtracted from two adjacent interpolated pixels to minimize the image distortion. Two interpolated pixels are calculated between each adjacent pixels to increase the embedding capacity. The experimental results show that the proposed scheme has better performance than other state-of-the-art interpolation based data hiding methods. Moreover, the proposed scheme has a low-time complexity with good visual quality. Finally, some standard steganographic analysis is used to measure the effectiveness of the proposed scheme. The intended result brought some remarkable sublime features to the limelight in the area of image verification, tamper identification and electronic forgery detection without which the technical life is hindered. This scheme profits enormously from numerous aspects of government and private sector including health-care, economic protection, defence, intellectual property rights and so on.
Evaluate the effects dredging on water quality parameters in Imam Khomeini Port
Authors: Azizi Fatemeh , Savari Ahmad , Shirali Solmaz , Safahieh Ali Reza , ZareDoust Mostafa 
Published: September 2022

Abstract
Aim: The projected dredging of the Musa Bay apart from its economic potentials was hinged on the following factors: Eutrophication, sedimentation and pollutants. This investigation surveyed the following parameters for surface samples: DO, pH, Conductivity, TDS, Nitrate, Phosphate, BOD, COD and Salinity.Methods: This study 9 points as sampling stations were chosen in Imam Khomeini Port (49˚05ˊ ;30˚25ˊ) that 3 replicates of each station water samples in the dark container for evaluating effects of the dredging was harvested. Water Sampling were collected from Imam Khomeini Port of Musa Bay, at 3 times before (Un-Dredging), during (Fresh-Dredging) and after (Post-Dredging) dredging was repeated.Results and discution: The mean DO value decrease from 3.78 to 2.85. Nutrients and Turbidity value increase during the dredging. Our study suggests that dredging may have potentials damages for aquatic environmental while these changes will improve with time shares.
Kaon-hyperon-nuclear systems in the Faddeev approach
Authors: Egorov Mikhail 
Published: September 2022

Abstract
The work addresses the development of the procedure to search for binding energies of three-body nuclei and exotic meson-nucleus systems based on the solution of homogeneous Faddeev integral equations without angular-momentum decomposition. The single components of such approach involves the two-body t-matrices which were searched for using coupled Lippmann-Schwinger equations and the Noyes-Kowalski subtractive procedure generalized for the case of angular-depending two-body potentials. Direct calculations of three-body binding energies have allowed establishing the correlation between the exact technique of finding the t-matrices and the approximated one using separable NN potentials as an example. Validation calculations of the binding energies of 3H, 3He nuclei have been performed with charge-dependent separable Bonn, Paris, and local ESC potentials which agree with the known experimental values at the accuracy of 10 to 180 keV. Realistic microscopic NN, YN, ꝀN, and KY interactions were used to study almost all possible bound states which can occur in ꝀNN, YNN and ꝀYN systems. Present calculations also confirm the existence of bound states of previously known K-pp, Λnp systems. The described method made it possible to accurately calculate the binding energies of K--p-Λ, K--n-Λ, K--d-Λ, K--3 He-Λ, K--4 He-Λ systems. The wave functions of the NNN, ꝀNN, ΛNN, and Λ K-p systems are also obtained and briefly analyzed.
A stationary population model with an "interior" boundary
Authors: Álvarez-Caudevilla Pablo , Brändle Cristina 
Published: September 2022

Abstract
We propose a stationary system that might be regarded as a migration model of some populations abandoning their original place of abode and becoming part of another population, once they reach the environment of the other population. To do so, we show a model where each population follows a logistic model in their own environment while assuming spatial heterogeneities. Moreover, both populations are coupled through the common boundary on which their flow moves in and out. The main goal we face in this work will be to describe the precise interplay between the stationary solutions with respect to the parameters involved in the problem, in particular the growth rate of the populations and the coupling parameter involved on the boundary where the interchange of flux is taking place.
Development And Synthesis Of Piezoelectric Materials Based On Natural Resources (Rocks)
Authors: Mebrouki Noura , Zenkhri Louiza , Tlili Salah , Boudjemaa Souhila , Belkhalfa Hakim , Benmabrouk Lazhar 
Published: September 2022

Abstract
This study reports the chemical composition of seven sandstones (OH1-OH7) from Ouargla desert in south-east of Algeria, then the investigation of these samples to be used as precursor for the hydrothermal synthetesis of piezoelectric mater in thin films form. Fourier-transform infrared (FT-IR) spectra shows the characteristic vibration bond peaks for the seven samples documenting the presence of quartz and calcite. Moreover, chemical composition of Ouargla sandstones has been determined by energy dispersive X-ray (EDS) and X-ray diffraction (XRD) allowed mainly a composition avrage major of 86.86 % α-quartz (SiO2) and minor of 13.14 % calcite (CaCO3). The EDS analysis revealed the presence of solid solution in the crystal lattice of six samples of the sandstones with trace amounts of Fe, Al, Ag, Na, K. The aqua regia digestion method was used to extract silicon and calcium from the rock samples in to synthesis the thin films. From (FT-IR), (SEM-EDS) and (XRD) we show that synthesis thin films at different temperture are composed mainly of 90.66 % calcite (CaCO3)/9.33 % α-quartz (SiO2) and 69 % α-quartz (SiO2)/31% Sodium Chloride (NaCl). The crystallite sizes of the sandstones were calculated and estimated to be nanometric, in contrast the thin films are not nanometric.
Drainage Pattern Phenomena in Sandy Arias in Arid Zones for Identification High Potential and Excellent Groundwater
Authors: Yousef Ahmed 
Published: September 2022

Abstract
The drainage pattern phenomenon in the sandy areas is rare in the world and has very high yields with excellent quality groundwater. It was recorded and tested in the Qattara Delta west of the River Nile. The study is based on data sets of remote sensing, groundwater wells, chemical analyses, pumping tests, stable isotopes, and field measurements. The drainage is trillic to dendritic, structurally controlled by NW, NE, and E-W fault systems, and has reduced flooding ability and a good chance for groundwater recharge. There are two main aquifers, Samalut karst and Nubian clastic. Samault
confined to semi-confined has huge thickness reach 395 m and groundwater flow from SSE to NNW. The structural elements and multiple sources of recharge much effect on the distribution of the salinity of groundwater which is less than 1000 in the southern part and increases northward to 2727 ppm owing to the decline in the rate of recharge from the River Nile, and dominant upward leakage from deep Nubian. The maximum drawdown exceeded 6 meters, transmissivity ranges from 6,200 to 45,900 m2/day, the storativity values vary from 8.2x10-6 to 8.6x10-4, and the overall static water level will decline in the ~15 meters over the first 10 years and then an additional 3 meters through a total of 50 years of continuous pumping. Samalut is less depleted in the south owing to the impact of the River Nile changed to moderately depleted in the center and depleted in the north part which means upward leakage from paleo-water of deep NSAS. The chemical properties and productivity of the central western part are affected by upward leakage from the deep Nubian Aquifer as springs through faults. A Nubian confined aquifer is tapped by one flowing well with a salinity of 1614 ppm, the transmissivity is 720 m2/day and the storativity is 1.5 X10-4. We can conclude that the productivity and hydrogeochemical properties of the aquifer of drainage pattern in the sandy areas are highly potential and have low salinity. This concept can be replicable in similar terrain elsewhere.
A facile one-pot, three-component protocol for, chiral synthesis of Cyanolactone as key intermediate of the Nafithromycin
Authors: Diwan Furqan , Pund Amit , Deshpande Prathmesh , Pursani Rajesh , Rafeeq Mohammad , Yadav Ram Prasad , Merwade Arvind 
Published: September 2022

Abstract
A facile one-pot, three-component protocol, for the large scale process of cyanide insertion was developed for synthesis of Cyanolactone (3) [Chemical name (11S, 21R)-11,12-dideoxy-6-O-methyl-2’,4’’-O-bis-(triethylsilyl)-12,11-[oxycarbonyl-(cyano)-methylene]-erythromycin A] as a key drug intermediate of Nafithromycin (6). The cesium carbonate used as a base for cyclisation and carried out insitu 1,4 Michael addition. Furthermore methanol as reaction promotor, which reacts with Trimethylsilyl cyanide (TMSCN) to produce methoxytrimethylsilane and liberate cyanide as nucleophile, which undergoes insitu nucleophilic substitution on 7 by SN2 pathway resulting in the asymmetric compound 3. This procedure has major advantages like insitu cyanide generation under close condition, cost-effective, short reaction time, good atom economy, ease of operation at manufacturing scale. The most significant aspect of the process was that it did not involve any direct handling of poisonous cyanide compounds like potassium or sodium cyanide. In addition, a key feature of optimization and isolation on kilogram scale is described herein.
The relation of VEGFA, VEGFR2, VEGI, and HIF1A genetic variants and their serum protein levels with breast cancer in Egyptian patients
Authors: Abdelgalil Amani , Monir Rehan , Elmetwally Mohamed , Bazeed Fagr , Mesbah Noha , Abo-Elmatty Dina , Mehanna Eman , Ghattas Maivel 
Published: September 2022

Abstract
Breast cancer is the most common type of cancer in Egyptian females. Polymorphisms in the angiogenesis pathway have been implicated previously in cancer risk and prognosis. The aim of the current study was to determine whether certain polymorphisms in the genes of vascular endothelial growth factor A (VEGFA), vascular endothelial growth factor receptor 2 (VEGFR2), vascular endothelial growth inhibitor (VEGI), and hypoxia-inducible factor-1α (HIF1A) associated with breast cancer development. The study included 154 breast cancer patients and 132 apparently healthy age-matched females as a control group. VEGFA rs25648 genotyping was performed using (ARMS) PCR technique; while VEGFR2 rs2071559, VEGI rs6478106, and HIF-1α rs11549465 were genotyped by the PCR-RFLP method. Serum levels of VEGF, VEGFR2, VEGI, and HIF1A proteins in breast cancer patients and controls were measured by ELISA. There was a significant association between the VEGFA rs25648 C allele and breast cancer risk (OR = 2.5, 95% CI = 1.7–3.6, p < 0.001). VEGFA rs25648 C/C genotype was statistically significantly higher in breast cancer patients vs. control (p < 0.001). Participants with the T/T and T/C VEGFR2 rs2071559 genotypes had 5.46 and 5 higher odds, respectively, of having breast cancer than those with the C/C genotype. For the VEGI rs6478106 polymorphism, there was a higher proportion of C allele in breast cancer patients vs. control (P = 0.003). Moreover, the C/C genotype of VEGI rs6478106 was statistically significantly higher in breast cancer patients vs. control (P = 0.001). There was no significant difference in genotypes and allele frequencies of HIF-1A rs11549465 polymorphism between breast cancer cases and control individuals (P > 0.05). Serum levels of VEGFA, VEGI, and HIF1A were considerably greater in women with breast cancer than in the control (P < 0.001). In conclusion, the genetic variants VEGFA rs25648, VEGFR2 rs2071559, and VEGI rs6478106 revealed a significant association with increased breast cancer risk in Egyptian patients.
An in silico investigation on the interactions of curcumin and epigallocatechin-3-gallate with NLRP3 Inflammasome complex
Authors: Jena Atala B. , Dash Umesh C. , Duttaroy Asim K. 
Published: September 2022

Abstract
Interleukin-1β (IL-1β) and IL-18 are the underlying factors of the inflammatory response and are necessary for the host's reaction and pathogen resistance. These cytokines also promote damage during chronic inflammation along with acute tissue injury. However, little is known about how these proteins are made and secreted from cells. Inflammasomes are multi-protein complexes which are required for the canonical synthesis of IL-1β. The NLRP3 inflammasome complex is one of the most studied inflammasome complexes. Its activation is dependent on two signals, i.e. one "primes" the cells by inducing the production of NLRP3 and pro-IL-1β, while the other causes the complex to assemble and activate. Lysosomal rupture, reactive oxygen species, and cytosolic ion perturbation function as the second signal. Despite extensive research, the exact role and regulation of the NLRP3 inflammasome are still unknown. In the current study, we investigated the inhibitory effect of plant-derived compounds such as curcumin and epigallocatechin-3-gallate (EGCG) on NLRP3-mediated IL-1β and IL-18 production using in silicoapproach. Our data suggest that the therapeutic effect of curcumin and EGCG may be due to the inhibition of inflammasome activation. The molecular and protein-protein interaction data indicated that the therapeutic effects of these two polyphenols are mediated by preventing the development of the NLRP3 complex.
Response surface methodology approach for dyeing process optimization of Ayous (Triplochiton scleroxylon) wood with acid dye
Authors: Wu Shiqian , Peng Limin , Fu Feng , Feng Yun , He Jinrong , Wang Huishan 
Published: September 2022

Abstract
Dyeing of wood is an important value-adding process. An important indicator in the assessment of the performance of wood dyeing process is the dye penetration. In present study, the existing method of response surface methodology was extended to study the dyeing process optimization of Ayous (Triplochiton scleroxylon) wood with acid dye using the radial dye penetration rate as an indicator. The experiments were carried out on the basis of a single factor experiment, and the optimal condition was determined by means of the Box-Behnken Design of response surface methodology. The effects of temperature, dye concentration, dyeing time and accelerant mass fraction on the radial dye penetration rate of Ayous wood were optimized. The experimental results showed that the maximum radial dye permeability can be achieved under optimum dyeing temperature (86.03 oC), dye concentration (0.31%), dyeing time (8 h), and accelerant mass fraction (2.23%). Under these conditions, the maximum dye-uptake and radial dye penetration rate were found to be 14.28% and 22.34%, respectively. The results of analysis of variance indicated that the mathematical model proposed in this study can be used to predict the dye-uptake and radial dye penetration rate of acid dye on Ayous wood by changing the process parameters.