bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constrained parameter-splitting perturbation method for the improved solutions of nonlinear vibrations of Euler-Bernoulli cantilever
Authors: Du Hai-En , Er Guo-Kang , Iu Vai Pan , Li Li-Juan 
Published: September 2022

Abstract
In this paper, a new method named constrained parameter-splitting perturbation method for improving the solutions obtained from the parameter-splitting perturbation method is proposed for solving the problems in some extremal cases, such as the strongly nonlinear vibration of Euler-Bernoulli cantilever. The proposed method takes the advantages of both the perturbation method and the harmonic balance method. The idea is that the solution obtained by the parameter-splitting perturbation method is substituted into the equation of motion and then the accumulative error of the equation is minimized for determining the unknown splitting parameters under the constrains constructed under the frame of harmonic balance method. The forced vibration of an oscillator with cubic geometric nonlinearity and inertia nonlinearity and the forced vibration of a planar micro cantilever beam with a lumped tip mass are studied as examples to reveal the efficacy of the proposed method. The inspection of the steady-state response is conducted by means of comparing the frequency-response curves obtained by the proposed method with those obtained by the numerical continuation method and harmonic balance method, respectively, to show the efficacy and the advantages of the proposed method. Meanwhile, the nonlinear ordering effect on the solutions of the proposed method is also studied by comparing the results obtained by using different nonlinear orderings in the systems.
Research on Flow experience and social influences of online short video users. An example of TikTok.
Authors: Cheng Zheng 
Published: September 2022

Abstract
Recently, the online short video has been highly recognized by the video market users, and then developed rapidly. This study aims to explore why users enjoy watching and sharing online short videos by applying the theory of flow experience. Previous research extensively examined traditional video arts such as TV and movies, and social media platforms that are text- or image-based, research on the online short video has been only surging in the recent years. In order to improve the preciseness and comprehensiveness of the research, social influence is also used as variables. This study takes short video representative platform TikTok as an example, and through questionnaires, 406 users' data about online short video experience were collected. After statistical analysis, the study finds that flow experience has a significant impact on the Follow and Share of online short video. According to further analyses, the research finds that flow experience, social norms, perceived critical mass and the Follow and Share constitute three groups of mediating relationship. Finally, through the discussion of the research results, it also provides help for broadening the academic scope of flow experience and video art, improving the online short video platform environment, and upgrading online short video services .
Co-pyrolysis of rice husk and cattle manure in N2/CO2 atmosphere
Authors: Liu Jiacheng , Qiu Wen , Ding Yongyu , Cheng Qunpeng , Fan Guozhi , Song Guangsen , Cui Baihui 
Published: September 2022

Abstract
The co-pyrolysis of rice husk and cattle manure was carried out in N2/CO2 atmosphere in a fixed pyrolysis furnace. The effects of pyrolysis temperature and ratio of rice husk to cattle manure on gas yield were studied. Thermo-gravimetric analyzer was used to explore the influence of rice husk on the pyrolysis process of cattle manure. Meanwhile, tar was analyzed by GC-MS to investigate the co-pyrolysis reactions of cattle manure with rice husk. The results showed that the co-pyrolysis of rice husk and cattle manure displayed a good synergistic effect where the mass loss rate was increased by 5.01%. It could significantly improved hydrogen production. Highest H2 content (26.34%) was obtained at 800℃ with the ratio of 1:0. Co-pyrolysis reduced the content and types of PAHs in tar, while increased the content of aliphatic hydrocarbons and oxygen-containing aliphatic hydrocarbons (ketones). Compared with N2 atmosphere, the contents of H2 and CO at CO2 atmosphere were increased by 30.25% and 30.69% respectively at 800℃ with the ratio of 1. At CO2 atmosphere, the pyrolysis of organic matter was promoted which resulted in a decrease of polycyclic aromatic hydrocarbons content and increase of aliphatic hydrocarbons and oxygen-containing aliphatic hydrocarbons content.
Environmental and economic performance investigation of natural gas and methanol as a marine alternative fuel.
Authors: Nasser Mahmoud Abdel , Elgohary Mohamed M. , Abdelnaby Maged , Shouman Mohamed R. 
Published: September 2022

Abstract
Emissions from ships are a serious global issue due to their effects on environmental damage, particularly global warming of the atmosphere. As a result, the International Maritime Organization (IMO) places a high priority on environmental protection by reducing exhaust emissions by at least 50% by 2050. Among the IMO's proposed measures, using alternative marine fuels such as natural gas and methanol instead of conventional fuels has been prioritised. In this paper, a comparative study between convert diesel engine into dual fuel engine operated with alternative fuels such as methanol or natural gas is carried out. Environmental and economic assessment of the natural-dual fuel engine and methanol- dual fuel engine is conducted. A13-class container ship is investigated as a case study. The evaluation results show that using natural gas in a dual fuel engine with a percentage (95% NG and 5% MDO) reduces NOx, SOX, CO2, PM, and CO pollutions by 83%, 95%, 19.4%, 95%, and 32.6%, respectively, while the emissions percentage will be 81.2%, 95%, 57.1%, 95%, and 58.4%, in order, when using methanol as a dual fuel with percentage 95% Methanol. Moreover, the cost-effectiveness of using natural gas was 769.25 $/ton, 3304.1$/ton, 81.2 $/ton. 60082.64 $/ton, and 23782.84 $/ton for NOx, SOx, CO2, PM, and CO, in the order, while for methanol, was 850.67 $/ton, 3340.1$/ton, 45.588 $/ton, 55450.87 $/ton, and 13274.11 $/ton, respectively.
Increased Risk of Group B Streptococcal Meningitis in Hiv-exposed Uninfected Infants in a High-Income Country
Authors: Manzanares Á. , Tato L. M. Prieto , Escosa-García L. , Navarro M. , Guillén S. , Penin M. , Hernanz-Lobo A. , Sánchez B. Soto , Mosquera J. Beceiro , Romero I. Falces , Amador J.T. Ramos , Miguel M.A. Orellana , Epalza C. 
Published: September 2022

Abstract
Purpose
to compare group B Streptococcus (GBS) infection incidence in HIV-exposed uninfected (HEU) and HIV-unexposed (HU) infants in a Spanish cohort.
Methods
retrospective study in 5 hospitals in Madrid (Spain). Infants ≤ 90 days of life with a GBS infection were included from January 2008 to December 2017. Incidence of GBS infection in HEU and HU children was compared.
Results
HEU infants presented a 7-fold greater risk of GBS infection and a 29-fold greater risk of GBS meningitis comparing to HU, with statistical signification. Early-onset infection was 10-fold more frequent in HEU children, with statistical signification, and late-onset infection was almost 5-fold more frequent in the HUE infants’ group, without statistical significance.
Conclusions
HEU infants presented an increased risk of GBS infection and meningitis. One in each 500 HEU infants of our cohort had a central nervous system infection and 1 in each 200, a GBS infection. Although etiological causes are not well understood, this should be taken into account by physicians when attending this population.
Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state
Authors: Maiti Atanu , Hedger Adam , Myint Wazo , Balachandran Vanivilasini , Watts Jonathan , Schiffer Celia , Matsuo Hiroshi 
Published: September 2022

Abstract
APOBEC3 proteins (A3s) are enzymes that catalyze deamination of cytidine to uridine in single-stranded DNA (ssDNA) substrates, thus playing a key role in innate antiviral immunity. However, APOBEC3 family has also been linked to many mutational signatures in cancer cells, which has led to intense interest to develop inhibitors of A3’s catalytic activity as therapeutics as well as tools to study A3’s biochemistry, structure and cellular function. Recent studies have shown that ssDNA containing 2′-deoxy-zebularine (dZ-ssDNA) is an inhibitor of A3s such as A3A, A3B and A3G, although atomic determinants of this activity remained unknown. To fill this knowledge gap, we determined a 1.5 Å resolution structure of a dZ-ssDNA inhibitor bound to active A3G. The crystal structure revealed that the activated dZ/H2O mimics the transition state by coordinating the active site Zn2+ and engaging in additional stabilizing interactions, such as the one with the catalytic residues E259. Therefore, this structure allowed us to capture the first snapshot of the A3’s transition state, and suggests that developing transition-state mimicking inhibitors may provide a new opportunity to design more targeted molecules for A3s in the future.
Clinicopathologic characteristics of early-onset breast cancer: A comparative analysis of cases from across Ghana
Authors: Akakpo Patrick Kafui , Imbeah Emmanuel Gustav , Edusei Lawrence , Naporo Simon , Ulzen-Appiah Kofi , Clegg-Lamptey Joe Nat , Dedey Florence , Nsaful Josephine , Affram Nelson , Wiafe Beatrice , Mensah Samuel , Nortey Michael , Sheriff Mohammed , Amponsah-Manu Forster , Agbedinu Kwabena , Jiagge Evelyn Mawunyo 
Published: September 2022

Abstract
Background: Breast cancer is the commonest cancer diagnosed globally and the second leading cause of cancer-related mortality among persons younger than 40 years. This study comparatively reviewed the demographic, pathologic and molecular features of Early-Onset Breast Cancer (EOBC) reported in Ghana in relation to Late Onset Breast Cancer (LOBC). Methods: A descriptive, cross-sectional design was used, with purposive sampling of retrospective histopathology data from 2019 to 2021. Core/incision biopsy, mastectomy and matched immunohistochemistry reports were merged into a single file and analysed with SPSS v. 20.0. Descriptive statistics of frequencies and percentages were used to describe categorical variables. Cross-tabulation and chi-square test was done at a 95% confidence interval with significance established at p<0.05Results: A total of 2,418 cases were included in the study with 20.2% (488 cases) being EOBCs and 79.8% (1,930 cases) being LOBCs. The median age at diagnosis was 34.66 (IQR: 5.55) in the EOBC group (<40 years) and 54.29 (IQR: 16.86) in the older, LOBC group (>/40 years). Invasive carcinoma - No Special Type (NST) was the commonest tumour type with grade III tumours being the highest recorded tumour grade in both age groups. Perineural invasion was statistically significant with age. EOBC was associated with higher DCIS component (24.8% vs 21.6%), lower hormone-receptor-positive status (52.30% vs 55.70%), higher proliferation index (Ki-67>20: 82.40% vs 80.30%) and a higher number of involved lymph nodes (13.80 vs 9.00%). Triple-Negative Breast cancer (26.40% vs 24.30%) was the most predominant molecular subtype of EOBC. Conclusion: EOBCs in our setting are generally more aggressive with poorer prognostic histopathological and molecular features when compared with LOBCs. A larger data set is needed to explain the lack of statistical significance of pathological features. Further molecular and genetic studies to understand the molecular genetic drivers of the general poorer outcome of EOBCs in our setting is recommended.
Dissipative control of switched nonlinear systems with sliding mode: an event-triggered control scheme
Authors: Dong Xiaoxiao , Zhang Xi 
Published: September 2022

Abstract
This paper introduces the event-triggered scheme to study the problems of dissipative control and dissipativity-based sliding mode control (SMC) for switched nonlinear systems. Firstly, based on a designed event-triggered scheme, a piecewise continuous state feedback controller is constructed, sufficient conditions for (Q,S,R)-α-dissipativity of the resulting system are derived by the approaches of a switched Lyapunov function and an average dwell time. Secondly, these two methods are extended to the study of H∞ performance and passive performance, the corresponding sufficient conditions are provided. Thirdly, the dissipative control problem is solved by introducing an event-triggered scheme into SMC method. Sufficient conditions for dissipativity of the resulting system are derived and an SMC law is designed to guarantee the reachability. At the end of this paper, the correctness of the proposed methods is proved by two numerical examples.
Comparison of bird assemblage structures and diversity patterns between seasons among the three Ethiopian wetlands
Authors: Awash Numeri , Tekalign Wondimagegnehu 
Published: September 2022

AbstractWetlands are significant habitats for avian populations, and knowledge of the diversity and other ecological aspects of bird species contribute to the management of the ecosystem. The present study was based on comparative studies of the diversity and relative abundance of bird species in the three wetlands of southwest Ethiopia. The point count method was utilized in this study. For the data analysis, the Shannon-Wiener diversity index, independent sample t-test, and similarity index were employed. A total of 46 bird species under 11 orders and 30 families were identified. The species diversity and relative abundance were higher in all three wetlands during the wet season. The Loga wetland had the highest diversity (H’ = 3.089), whereas the lowest diversity (H’ = 2.643) was recorded in the wetland of Hurri. During the dry season, the highest and the lowest diversity were also recorded in the Loga wetland (H’ = 2.738) and the Hurri habitat (H’ = 2.283), respectively. Seasonal differences in the species diversity of bird species are not statistically significant (p > 0.05). Since the existence of bird species is reliant on a wetland ecosystem; human activities very close to the wetland should be controlled for their sustainable conservation.
Comprehensive analysis to identify long non-coding RNA HCP5/MICA axis as a prognostic biomarker in glioblastoma
Authors: Qin Qilin , Mao Wenbin , Zhang Xuezhi , Wang Xinzhuang 
Published: September 2022

Abstract
Purpose
To explore the lncRNA-mRNA network based on the IDH1 mutation status and construct a prognostic model for GBM.
Methods
The data of expression, somatic mutation, methylation, immune microenvironment were obtained from TCGA database, CGGA database and GTEx database. The common differential expressed genes (DEGs) between IDH1 mutant GBM and IDH1 wildtype GBM were used to perform a series of bioinformatics analysis to identify the hub gene. LASSO cox regression was used to screen a risk signature and nomogram was used to construct a prognostic model for GBM.
Results
LncRNA HCP5/MICA axis was downregulated in IDH1 mutant GBM and associated with the overall survival (OS) of GBM patients. Further analysis revealed that MICA expression was positively correlated with immune infiltration as well as the expression of several immune checkpoint gene in GBM. We screened a risk signature using MICA-associated genes by LASSO cox regression and the risk score performed well in predicting the OS. Furthermore, the risk score was used to construct a nomogram prognostic model combined with age, gender, IDH mutation, TP53 mutation, radiation and chemotherapy to predict the OS at 1-year, 2-year and 5-year.
Conclusions
This study constructed a prognostic model for GBM with MICA and clinical data for the first time and provided an insight into the molecular therapy of GBM. Further studies are required to uncover the mechanism of regulation between HCP5 and MICA in GBM.
Does knowledge acquisition transform clinical practice? Continuing medical education designed for knowledge improvement can significantly alter diagnoses and care maintenance across specialties: A randomized study of statistical inference
Authors: Ruggiero John , Meo Antonio B. , Bishay M. Theresa , Azzi Brigitte , Urhoghide Osarumen , Malnarick Gail 
Published: September 2022

Abstract
Background
Accredited continuing medical education contributes to the acceleration of scientific information into practice. Additional evidence confirming an ongoing debate that knowledge-based education directly results in practice change, apart from education designed specifically for Quality Improvement, would however complement the current inventory of literature related to the impact of continuing education. This study therefore examined if reinforcing multiple knowledge-building continuing medical education activities lead to or correlates with clinical confidence and rates of practice change.
Methods
From March 17, 2022, to May 11, 2022, a randomized sample of U.S. healthcare professionals (N = 500), including but not limited to physicians, nurses, and pharmacists working across specialties and practices, provided their perspectives on accredited educational activities they completed within the previous six months. Participants then matched their practice notes to recommendations made within the education.
Results
75.3% documented enhanced personalized and proper diagnoses, enhanced diagnostic test orders, and alternative care plan implementation. A Z-test compared this average to that of previous research (33%). A directional hypothesis test with 0.5 alpha level of significance led to hypothesis acceptance with 95% confidence. Additional Pearson correlation testing indicated a positive relationship between education and diagnostic test orders, proactive adverse event management, and personalized care plan changes (r = 0.55, 0.64, and 0.66, respectively), with positive linear regression (r2 = 0.30, 0.41, and 0.44, respectively). When clustered by practice setting and time in practice, there were no statistical differences in the results.
Conclusions
Accredited continuing education, designed for knowledge-acquisition, can lead to practice change across clinical specialties and practices, irrespective of a clinician’s time in practice. This research is meant to generate hypotheses and continued discourse within the clinical and educational communities.
Mapping of quantitative trait loci (QTLs) controlling cotton leaf curl disease (CLCuD) resistance in Upland cotton
Authors: Sattar Muhammad N. , Javed Muhammad , Hussain Syed B. , Babar Muhammad , Chee Peng W. , Iqbal Zafar , Munir Muhammad , Al-Hashedi Sallah A. 
Published: September 2022

AbstractCotton leaf curl disease (CLCuD), caused by begomoviruses, is a major threat to cotton (Gossypium hirsutum L.) production, especially in Asia and Africa. The use of marker-assisted breeding to utilize host plant resistance can be the best sustainable approach to tackle CLCuD. Because most of the available cotton germplasm is susceptible to CLCuD, so it demands the identification of potentially new quantitative trait loci (QTLs) in the indigenous germplasm. The current study was designed to construct a broader genetic linkage map of bi-parental F2:F3 populations developed from a highly tolerant MNH 886 and a highly susceptible S-12 cotton cultivars. One hundred seven (107) CLCuD-associated simple sequence repeat (SSR) marker alleles were identified as polymorphic and eight new QTLs were found on chromosomes 11, 19 and 21. On homologous chromosomes 11 and 17, the QTLs qCL-11-120d2 and qCL-21-m2 were detected in both F2 and F3 populations. Another QTL on chromosome 11, qCL-11-m3, showed the highest phenotypic variance (PV%) of 16.66% and LOD score > 3. Other QTLs on chromosome 11 were qCL-11-m2, qCL-11-120d3. On chromosome 19, three QTLs (qCL-19-m2, qCL-19-90d2 and qCL-19-120d3) were detected with PV% >8 and LOD score > 3. The CLCuD-associated QTLs identified in this study can contribute to develop CLCuD-resistant cultivars using marker assisted selection and can help to fine-tune the molecular mapping of the QTLs on the cotton genome.
High Ki67 expression before docetaxel, cisplatin, and fluorouracil (TPF) neoadjuvant chemotherapy predicts better prognosis in patients with locally advanced oral squamous cell carcinoma
Authors: Zhou Xin-yu , Chen Gang , Zhao Tong-chao , Yao Yu , Zhang Zhi-yuan , Zhou Zhi-hang , Zhong Lai-ping , Zhu Dong-wang 
Published: September 2022

AbstractBackground Patients with locally advanced oral squamous cell carcinoma (OSCC) failed to benefit from docetaxel, cisplatin and 5-fluorouracil (TPF) neoadjuvant chemotherapy prior to surgery and postoperative radiotherapy in our previous phase 3 trial (NCT01542931). The aim of the present study was to explore the prognostic value of Ki67 expression for individualized TPF neoadjuvant therapy. Methods Immunohistochemical staining of Ki67 was performed in the biopsies before treatment in the experimental arm of our previous phase 3 trial. A total of 65 patients with Ki67 expression below 25% or above 50% were retrospectively reviewed in this study. Kaplan‑Meier analysis, log-rank test and Cox proportional hazards model were used for survival analysis. Results Among the 65 patients enrolled in the study, the patients with high Ki67 expression (n = 41) before treatment exhibited higher overall survival (OS) (P = 0.041) and distant metastasis–free survival (DMFS) (P = 0.049) than those with low expression (n = 24). The 5-year OS of the two groups were 70.7% and 45.8% respectively (high vs low). Cox proportional hazards model showed that high Ki67 expression before TPF neoadjuvant chemotherapy had a positive impact on the OS (HR = 0.399, 95% CI: 0.178–0.893, P = 0.025). Conclusions High Ki67 expression before treatment could predict the survival benefits from TPF neoadjuvant chemotherapy prior to standard therapy in patients with locally advanced OSCC, which could act as a biomarker for individualized treatment.
A disintegrin and metalloproteinase 10 (ADAM10) is essential for oligodendrocyte precursor development and myelination in the mouse brain
Authors: Guo Dazhi , Huang Fei , xue ruijun , Ma Yuehong , Xiao Lin , Lou Huifang , pan shuyi 
Published: September 2022

AbstractA disintegrin and metalloproteinase 10 (ADAM10) plays an essential role in the regulation of survival, proliferation, migration, and differentiation of various neural cells. Nevertheless, the role of ADAM10 in oligodendrocyte precursors (OPCs) and myelination in the central nervous system (CNS) of developing and adult mouse brains is still unknown. We generated ADAM10 conditional knockout (ADAM10 cKO) mice lacking the ADAM10 gene primarily in OPCs by crossing NG2-Cre mice with ADAM10loxp/loxpmice. We found that OPCs expressed ADAM10 in the mouse corpus callosum and the hippocampus. ADAM10 cKO mice showed significant loss of back hair and reduction in weight and length on postnatal (30 ± 2.1) day, died at (65 ± 5) days after birth and exhibited the “anxiety and depression-like” performances. Conditional knockout of ADAM10 in OPCs resulted in a prominent increase in myelination and a decrease in the number of OPCs in the corpus callosum at P30 owing to premyelination and lack of proliferation of OPCs. Moreover, the number of proliferating OPCs and mature oligodendrocytes (OLs) also decreased with age in the corpus callosum of ADAM10 cKO mice from P30 to P60. Western blot and RT-PCR results showed that the activation of Notch-1 and its four target genes, Hes1, Hes5, Hey1, and Hey2, was inhibited in the corpus callosum tissue of ADAM10 knockout mice. In our study, we provided experimental evidence to demonstrate that ADAM10 is essential for modulating CNS myelination and OPC development by activating Notch-1 signalling in the developing and adult mouse brain.