bluuebunny/crossref_metadata_2025_split huggingface dataset:
Data-driven approach to implementation mapping for the selection of implementation strategies: a case example for risk-aligned bladder cancer surveillance
Authors: Schroeck Florian R. , Ould Ismail A. Aziz , Haggstrom David A. , Sanchez Steven L. , Walker DeRon R. , Zubkoff Lisa 
Published: September 2022

Abstract
Background
Implementation Mapping is an organized method to select implementation strategies. However, there are 73 Expert Recommendations for Implementing Change (ERIC) strategies. Thus, it is difficult for implementation scientists to map all potential strategies to the determinants of their chosen implementation science framework. Prior work using Implementation Mapping employed advisory panels to select implementation strategies. This article presents a data-driven approach to implementation mapping, in which we systematically evaluated all 73 ERIC strategies using the Tailored Implementation for Chronic Diseases (TICD) framework. We illustrate our approach using implementation of risk-aligned bladder cancer surveillance as a case example.

Methods
We developed objectives based on previously collected qualitative data organized by TICD determinants, i.e., what needs to be changed to achieve more risk-aligned surveillance. Next, we evaluated all 73 ERIC strategies, excluding those that were not applicable to our clinical setting. The remaining strategies were mapped to the objectives using data visualization techniques to make sense of the large matrices. Finally, we selected strategies with high impact, based on (1) broad scope, defined as a strategy addressing more than the median number of objectives, (2) requiring low or moderate time commitment from clinical teams, and (3) evidence of effectiveness from the literature.

Results
We identified 63 unique objectives. Of the 73 ERIC strategies, 45 were excluded because they were not applicable to our clinical setting (e.g., not feasible within the confines of the setting, not appropriate for the context). Thus, 28 ERIC strategies were mapped to the 63 objectives. Strategies addressed 0 to 26 objectives (median 10.5). Of the 28 ERIC strategies, 10 required low and 8 moderate time commitments from clinical teams. We selected 9 strategies based on high impact, each with a clearly documented rationale for selection.

Conclusions
We enhanced Implementation Mapping via a data-driven approach to the selection of implementation strategies. Our approach provides a practical method for other implementation scientists to use when selecting implementation strategies and has the advantage of favoring data-driven strategy selection over expert opinion.
Rationale and design of the “NEurodegeneration: Traumatic brain injury as Origin of the Neuropathology (NEwTON)” study: a prospective cohort study of individuals at risk for chronic traumatic encephalopathy
Authors: van Amerongen Suzan , Caton Dewi K. , Ossenkoppele Rik , Barkhof Frederik , Pouwels Petra J. W. , Teunissen Charlotte E. , Rozemuller Annemieke J. M. , Hoozemans Jeroen J. M. , Pijnenburg Yolande A. L. , Scheltens Philip , Vijverberg Everard G. B. 
Published: September 2022

Abstract
Background
Repetitive head injury in contact sports is associated with cognitive, neurobehavioral, and motor impairments and linked to a unique neurodegenerative disorder: chronic traumatic encephalopathy (CTE). As the clinical presentation is variable, risk factors are heterogeneous, and diagnostic biomarkers are not yet established, the diagnostic process of CTE remains a challenge. The general objective of the NEwTON study is to establish a prospective cohort of individuals with high risk for CTE, to phenotype the study population, to identify potential fluid and neuroimaging biomarkers, and to measure clinical progression of the disease. The present paper explains the protocol and design of this case-finding study.

Methods
NEwTON is a prospective study that aims to recruit participants at risk for CTE, with features of the traumatic encephalopathy syndrome (exposed participants), and healthy unexposed control individuals. Subjects are invited to participate after diagnostic screening at our memory clinic or recruited by advertisement. Exposed participants receive a comprehensive baseline screening, including neurological examination, neuropsychological tests, questionnaires and brain MRI for anatomical imaging, diffusion tensor imaging (DTI), resting-state functional MRI (rsfMRI), and quantitative susceptibility mapping (QSM). Questionnaires include topics on life-time head injury, subjective cognitive change, and neuropsychiatric symptoms. Optionally, blood and cerebrospinal fluid are obtained for storage in the NEwTON biobank. Patients are informed about our brain donation program in collaboration with the Netherlands Brain Brank. Follow-up takes place annually and includes neuropsychological assessment, questionnaires, and optional blood draw. Testing of control subjects is limited to baseline neuropsychological tests, MRI scan, and also noncompulsory blood draw.

Results
To date, 27 exposed participants have finished their baseline assessments. First baseline results are expected in 2023.

Conclusions
The NEwTON study will assemble a unique cohort with prospective observational data of male and female individuals with high risk for CTE. This study is expected to be a primary explorative base and designed to share data with international CTE-related cohorts. Sub-studies may be added in the future with this cohort as backbone.
Good maternal and fetal outcomes of three consecutive pregnancies in a Mediterranean woman with Alport syndrome: a case report
Authors: Rawashdeh Hasan , Alchalabi Haifaa A. , Oweis Ashraf O. , Al Jalodi Haneen 
Published: September 2022

Abstract
Background
Alport syndrome is a rare inherited disorder affecting the glomerular basement membrane, manifested by hematuria and proteinuria that is commonly associated with ocular and hearing defects. There is limited information about the maternal and fetal outcomes of Alport syndrome in pregnancy.

Case presentation
We describe a smooth course of pregnancy, a good maternal outcome, and a good fetal outcome in three consecutive pregnancies for a 35-year-old Mediterranean woman with Alport syndrome over a 10-year duration. Although there was a nephrotic range of progressive proteinuria in all her pregnancies, there was a prompt drop in proteinuria within 2 weeks of her deliveries. She has constantly shown a normal serum creatinine level and a normal serum protein level in all her pregnancies. Apart from a single episode of asymptomatic hypertension in her second pregnancy at 34 weeks of gestation that returned to a normal range immediately after delivery, she was normotensive antenatally and postnatally. She gave birth by cesarean section to three healthy newborns.

Conclusions
A normal prepregnancy creatinine level and a mild range of proteinuria in a patient with normotension, who is not on any medication, are associated with good maternal and fetal outcomes. Furthermore, successful pregnancy that is followed by a normal renal function test might suggest a favorable outcome for any future pregnancy.
Intestinal cellular heterogeneity and disease development revealed by single-cell technology
Authors: Wang Yalong , Song Wanlu , Yu Shicheng , Liu Yuan , Chen Ye-Guang 
Published: September 2022

AbstractThe intestinal epithelium is responsible for food digestion and nutrient absorption and plays a critical role in hormone secretion, microorganism defense, and immune response. These functions depend on the integral single-layered intestinal epithelium, which shows diversified cell constitution and rapid self-renewal and presents powerful regeneration plasticity after injury. Derailment of homeostasis of the intestine epithelium leads to the development of diseases, most commonly including enteritis and colorectal cancer. Therefore, it is important to understand the cellular characterization of the intestinal epithelium at the molecular level and the mechanisms underlying its homeostatic maintenance. Single-cell technologies allow us to gain molecular insights at the single-cell level. In this review, we summarize the single-cell RNA sequencing applications to understand intestinal cell characteristics, spatiotemporal evolution, and intestinal disease development.
BTP: automatic identification and prediction of tasks in data center networks
Authors: Zou Shaojun , Ji Wei , Huang Jiawei 
Published: September 2022

AbstractModern data centers have widely deployed lots of cluster computing applications such as MapReduce and Spark. Since the coflow/task abstraction can exactly express the requirements of cluster computing applications, various task-based solutions have been proposed to improve application-level performance. However, most of solutions require modification of the applications to obtain task information, making them impractical in many scenarios. In this paper, we propose a Bayesian decision-based Task Prediction mechanism named BTP to identify task and predict the task-size category. First, we design an automatic identification mechanism to identify tasks without manually modifying the applications. Then we leverage bayesian decision to predict the task-size category. Through a series of large-scale NS2 simulations, we demonstrate that BTP can accurately identify task and predict the task-size category. More specifically, BTP achieves 96% precision and 92% recall while obtaining accuracy by up to 98%.
Citation analysis of the 100 top-cited articles on discectomy via endoscopy since 2011 using alluvial diagrams: bibliometric analysis
Authors: Yeh Chao-Hung , Chien Tsair-Wei , Chou Po-Hsin 
Published: September 2022

Abstract
Background
Percutaneous endoscopic lumbar discectomy (PELD) is synonymous with percutaneous endoscopic transforaminal discectomy (PETD) and percutaneous endoscopic interlaminar discectomy (PEID). PEID has gained increasing recognition for its small incision, quick recovery, short hospital stay, and equivalent clinical outcome to open surgery. Numerous articles related to PEID have been published in the literature. However, which countries, journals, subject categories, and articles have ultimate influence remains unknown. The study aimed to (1) display influential entities in 100 top-cited PEID-related articles (T100PEID) on the alluvial diagram and (2) investigate whether medical subject headings (i.e., MeSH terms) can be used to predict article citations.

Methods
T100PEID data can be found since 2011 in the PubMed and Web of Science (WOS) databases. Using alluvial diagrams, citation analysis was conducted to compare the dominant entities. We used social network analysis (SNA) to classify MeSH terms and research areas extracted from PubMed and WOS. The difference in article citations across subject categories and the predictive power of MeSH terms on article citations in T100 PEID were examined using one-way analysis of variance (ANOVA) and regression analysis.

Results
A total of 81% of T100PEID is occupied by the top three countries (the US, China, and South Korea). There was an overall T100PEID impact factor of 41.3 (IF = citations/100). Articles were published in Spine (Phila Pa 1976) (23%; IF = 41.3). Six subject categories were classified using the SNA. The most cited article authored by D Scott Kreiner from Ahwatukee Sports and Spine in the US state of Phoenix had 123 citations in PubMed. The network characteristics of T100PEID are displayed on the alluvial diagram. No difference was found in article citations among subject categories (F = 0.813, p = 0.543). The most frequently occurring MeSH term was surgery. MeSH terms were evident in the prediction power of the number of article citations (F = 15.21; p < 0 .001).

Conclusion
We achieved a breakthrough by displaying the T100PEID network characteristics on the alluvial plateau. The MeSH terms can be used to classify article subject categories and predict T100PEID citations. The alluvial diagram can be applied to bibliometrics on 100 top-cited articles in future studies.
Effect of tofacitinib on dactylitis and patient-reported outcomes in patients with active psoriatic arthritis: post-hoc analysis of phase III studies
Authors: Orbai Ana-Maria , Mease Philip J. , Helliwell Philip S. , FitzGerald Oliver , Fleishaker Dona L. , Mundayat Rajiv , Young Pamela 
Published: September 2022

AbstractBackgroundTofacitinib is an oral Janus kinase inhibitor for the treatment of psoriatic arthritis (PsA). This post-hoc analysis of two phase III studies in patients with PsA treated with tofacitinib assessed dactylitis by location, and the impact on patient-reported outcomes (PROs).MethodsPatients received tofacitinib 5 or 10 mg twice daily (BID), or placebo. Endpoints included change from baseline in Dactylitis Severity Score (DSS), proportions of patients with dactylitis, Psoriatic Arthritis Disease Activity Score (PASDAS), and PROs (Health Assessment Questionnaire-Disability Index [HAQ-DI]; Functional Assessment of Chronic Illness Therapy-Fatigue [FACIT-F]; Short Form-36 Health Survey [SF-36] Physical Component Summary [PCS], Mental Component Summary [MCS], and physical functioning [PF]; arthritis pain; and Work Limitations Questionnaire [WLQ]). Descriptive statistics were generated by visit and treatment. Change from baseline in PROs were evaluated by multivariate linear regression.ResultsThe analysis included 373/337 patients with baseline DSS > 0/DSS = 0. Regardless of location, DSS improvements in patients with DSS > 0 were greater from month 1 with tofacitinib (10 mg BID) versus placebo. For patients with DSS > 0/DSS = 0, both doses of tofacitinib led to mean dactylitis presence ≤ 15%/< 2% for all digits at month 6, and PASDAS (by dactylitis location) was lower versus placebo at month 3. Dactylitis location was not significantly associated with change from baseline in PROs.ConclusionTofacitinib resulted in sustained improvements in dactylitis irrespective of location, with minimal emergence of new dactylitis.Trial registrationNCT01877668; NCT01882439.
Deteriorating Quality of Life and a Desire to Stop Growing Tobacco Among Virginia and Burley Tobacco Farmers in Thailand
Authors: Phetphum Chakkraphan , Prajongjeep Atchara , Keeratisiroj Orawan , Simsin Saksin , Thawatchaijareonying Kanyarat 
Published: September 2022

PURPOSE This study aimed to examine the quality of life of tobacco farmers and their desire to stop growing tobacco. METHODS A cross-sectional home-based survey was conducted between October 2021 and January 2022 among 2,970 Virginia and Burley tobacco farmers in Northern Thailand. Multivariate logistic regression models were used to determine the association between farmers' characteristics and their quality of life and a desire to stop planting tobacco. RESULTS In total, 58.5% of the participants wanted to stop growing tobacco, and most had a lower quality of life than the mean. Nine independent variables were associated with a desire to stop tobacco farming: having a low level of economic quality of life (adjusted odds ratio [ORAdj], 5.42; 95% CI, 3.8 to 7.8); having a high environmental quality of life (ORAdj, 4.60; 95% CI, 3.3 to 6.5); belonging to the Tobacco Farmers' Association (ORAdj, 3.04; 95% CI, 2.1 to 4.5); growing tobacco on their own land (ORAdj, 2.12; 95% CI, 1.8 to 2.6); having a low social quality of life (ORAdj, 1.69; 95% CI, 1.4 to 2.1); having a low health quality of life (ORAdj, 1.69; 95% CI, 1.4 to 2.1); having a low spiritual quality of life (ORAdj, 1.41; 95% CI, 1.2 to 1.7); being Burley tobacco farmers (ORAdj, 1.33; 95% CI, 1.0 to 1.8); and having a low family quality of life (ORAdj, 0.49; 95% CI, 0.4 to 0.6). CONCLUSION The majority of the tobacco farmers had a declining quality of life, particularly economic and environmental quality of life, resulting in reducing growing tobacco. National and regional support are needed to help these farmers effectively grow alternative crops, and financial support to make such conversions.
Physical Isolation and Viral Information in Mira Grant’s Newsflesh Stories
Authors: Halpin Jenni G. 
Published: September 2022

Set in the ongoing Kellis-Amberlee pandemic, Mira Grant’s zombie adventure series Newsflesh (2010–2016) conjoins knowledge-power with the physical and technological apparatuses of control for a group of narratives that place citizens against the government. The ongoing apocalypse is untenable, as exemplified in the radically constricted lives most people live in efforts to protect themselves from people or other mammals who have been transformed into zombies by the virus. This constriction, and therefore the extension of government framing of the pandemic as a crisis condition, consolidates power in the hands of a CDC (Centers for Disease Control and Prevention) that is actively and secretly working to eliminate human adaptive responses to the virus.
“Physical Isolation and Viral Information in Mira Grant’s Newsflesh” explores the connections between knowledge, scientific authority, physical distancing, and collective action. Given the figural power of zombies, the apparatuses for control of the vulnerable and dangerous bodies in this uncontrolled pandemic substitute – and obscure the need for – widespread sharing not only of facts but of understanding the implications of those facts. Two decades of misinformation and fear campaigns, in Newsflesh, trampled the legacy of “the Rising” and transformed the survivors from collective actors who shared what they learned in their attempts to stay alive into fearful isolationists who lack the knowledge to exercise power or enact community. The abuses of power discovered by the characters in these texts point to possible ways of not merely surviving but of living amid the zombie pandemic.
Susceptibility to risky sexual behaviours in the polish population aged 15-63
Authors: Wojciechowski Piotr , Żurek Katarzyna , Wujec Zuzanna , Nawrocki Maciej 
Published: September 2022

Frequent involvement in risky sexual behaviors among members of society is a threat to their health. It’s also a social problem, as it increases the risk of spreading STDs and unwanted pregnancies.
The aim of the study was to check the susceptibility to risky sexual behaviors in the Polish population aged 15-63. The research method was an original online questionnaire. A total of 294 responses were obtained from people of different gender, age, place of residence and level of education. The results were then statistically analyzed.
84% of respondents had undergone sexual initiation. The remaining respondents were excluded from further study. The average age of initiation was 18.2 years.
73% of respondents claim to never use condoms during oral sex. 22% of respondents use other methods instead of condoms. In the past 12 months, 21% of respondents had more than 1 sexual partner and 36% often had sex after drinking alcohol. 60% of respondents have never tested for STDs, and only 5% do it regularly when changing sexual partners.
Subjects of concern are: large proportion of respondents who do not protect themselves during oral sex, a small number of respondents who regularly get tested for STDs, and a significant group of people who declare that they frequently have sex under the influence of alkohol.
Johannes Bobrowski und seine Kant-Erzählung
Authors: Pakalski Dariusz 
Published: September 2022

Johannes Bobrowski i jego opowiadanie o Kancie
Johannes Bobrowski (ur. W Tylży, uczęszczał do Gimnazjum Miejskiego w Królewcu) obrał za „główny temat” swoich dzieł historyczno-kulturowe dziedzictwo swej ojczyzny. Jednym z jego historyczno-biograficznych odniesień do przeszłości jest opowiadanie „Epitafium dla Pinnaua”, gdzie rozmowa prowadzona na obiedzie u Kanta krąży wokół samobójstwa tego młodego księgowego i znajomego J. G. Hamanna. Tekst stanowi próbę podjęcia w tej perspektywie refleksji na temat filozoficznych postaw obu „krytycznych przyjaciół” – Kanta i Hamanna.
Skin cancer: getting back to basics
Authors: Machin Claire , Alchorne Jayne 
Published: September 2022

Skin cancer is the most common form of cancer in the UK. Claire Machin and Jayne Alchorne provide an overview of the causes of skin cancer, patients most at risk and provide advice for when and how to refer for specialist advice, as well as information on prevention The article aims to provide a timely refresher to all health professionals working in primary care on skin cancer. Our interaction with patients, no matter what form it takes, places us in a unique and privileged position to observe and protect patients from a potentially disfiguring and life-threatening skin cancer. The skin is easily accessible, which enables the early detection and referral of potential skin cancers. This article will explore what causes skin cancer, patients most at risk, define the different types and most common forms of skin cancer, and provide advice for when and how to refer for specialist advice. The fundamental principles of sun safety will also be explored to ensure skin cancer prevention remains at the forefront of agendas.
Thirty years of experience with instrumented femoral impaction bone grafting and a cemented polished Exeter stem
Authors: Özdemir Erim , Kuijpers Martijn F. L. , Visser Jetze , Schreurs B. W. , Rijnen Wim H. C. 
Published: September 2022

AimsThe aim of this study is to report the long-term outcomes of instrumented femoral revisions with impaction allograft bone grafting (IBG) using the X-change femoral revision system at 30 years after introduction of the technique.MethodsWe updated the outcomes of our previous study, based on 208 consecutive revisions using IBG and the X-change femoral revision system in combination with a cemented polished stem, performed in our tertiary care institute between 1991 and 2007. Kaplan-Meier survival analyses were used to determine the survival rate of the revisions with endpoint revision for any reason and aseptic loosening. Secondary outcomes were radiological loosening and patient-reported outcome measures.ResultsMean age at revision total hip arthroplasty (THA) was 64.9 years (30 to 86). The most prevalent diagnosis for the femoral revision was aseptic loosening. At review in May 2021, 81 patients (85 hips) were still alive and 118 patients (120 hips; 58%) had died. Three patients (3 hips; 1%) were lost to follow-up at 11, 15, and 16 years after surgery, respectively. Data of all deceased and lost patients were included until final follow-up. The mean follow-up was 13.4 years (0 to 28). During the follow-up, 22 re-revisions were performed. The most common reason for re-revision was infection (n = 12; 54%). The survival with endpoint re-revision for any reason was 86% (95% confidence interval (CI) 79 to 91) at 20 years and 74% (95% CI 43 to 89) at 25 years after surgery. The survival for endpoint re-revision for aseptic loosening was 97% (95% CI 91 to 99) after both 20 and 25 years.ConclusionWe conclude that femoral IBG is a valuable technique that can reconstitute femoral bone loss in the long term. After 25 years of follow-up, few re-revisions for aseptic loosening were required. Also, the overall revision rate is very acceptable at a long follow-up. This technique is especially attractive for younger patients facing femoral revisions with extensive bone loss. Cite this article: Bone Joint J 2022;104-B(9):1039–1046.
Prediction tools for the personalized management of soft-tissue sarcomas of the extremity
Authors: Acem Ibtissam , van de Sande Michiel A. J. 
Published: September 2022

Prediction tools are instruments which are commonly used to estimate the prognosis in oncology and facilitate clinical decision-making in a more personalized manner. Their popularity is shown by the increasing numbers of prediction tools, which have been described in the medical literature. Many of these tools have been shown to be useful in the field of soft-tissue sarcoma of the extremities (eSTS). In this annotation, we aim to provide an overview of the available prediction tools for eSTS, provide an approach for clinicians to evaluate the performance and usefulness of the available tools for their own patients, and discuss their possible applications in the management of patients with an eSTS. Cite this article: Bone Joint J 2022;104-B(9):1011–1016.