bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive-behavioural pathways from pain to poor sleep quality and emotional distress in the general population: The indirect effect of sleep-related anxiety and sleep hygiene
Authors: Rakhimov Arman , Whibley Daniel , Tang Nicole K. Y. 
Published: January 2022

Objectives
Pain can have a negative impact on sleep and emotional well-being. This study investigated whether this may be partly explained by maladaptive sleep-related cognitive and behavioural responses to pain, including heightened anxiety about sleep and suboptimal sleep hygiene.

Methods
This cross-sectional study used data from an online survey that collected information about pain (Brief Pain Inventory), sleep (Pittsburgh Sleep Quality Index; Sleep Hygiene Index; Anxiety and Preoccupation about Sleep Questionnaire) and emotional distress (PROMIS measures; Perceived Stress Scale). Structural equation modelling examined the tenability of a framework linking these factors.

Results
Of 468 survey respondents (mean age 39 years, 60% female), 29% reported pain (mean severity 1.12), most commonly in the spine or low back (28%). Pain severity correlated with poor sleep quality, poor sleep hygiene, anxiety about sleep and emotional distress. In the first structural equation model, indirect effects were identified between pain severity and sleep quality through anxiety about sleep (β = .08, p < .001) and sleep hygiene (β = .12, p < .001). In the second model, an indirect effect was identified between pain severity and emotional distress through sleep quality (β = .19, p < .01). Combining these models, indirect effects were identified between pain severity and emotional distress through anxiety about sleep, sleep hygiene and sleep quality.

Conclusions
This study provides data to support the tenability of a theoretically guided framework linking pain, sleep and emotional distress. If upheld by experimental and/or longitudinal study, this framework holds the potential to inform public health initiatives and more comprehensive pain assessment.
Use of glucocorticoids megadoses in SARS-CoV-2 infection in a spanish registry: SEMI-COVID-19
Authors: Lavilla Olleros Cristina , Ausín García Cristina , Bendala Estrada Alejandro David , Muñoz Ana , Wikman Jogersen Philip Erick , Fernández Cruz Ana , Giner Galvañ Vicente , Vargas Juan Antonio , Seguí Ripoll José Miguel , Rubio-Rivas Manuel , Miranda Godoy Rodrigo , Mérida Rodrigo Luis , Fonseca Aizpuru Eva , Arnalich Fernández Francisco , Artero Arturo , Loureiro Amigo Jose , García García Gema María , Corral Gudino Luis , Jiménez Torres Jose , Casas-Rojo José-Manuel , Millán Núñez-Cortés Jesús ,   On behalf of the SEMI-COVID-19 Network
Published: January 2022

Objective
To describe the impact of different doses of corticosteroids on the evolution of patients with COVID-19 pneumonia, based on the potential benefit of the non-genomic mechanism of these drugs at higher doses.

Methods
Observational study using data collected from the SEMI-COVID-19 Registry. We evaluated the epidemiological, radiological and analytical scenario between patients treated with megadoses therapy of corticosteroids vs low-dose of corticosteroids and the development of complications. The primary endpoint was all-cause in-hospital mortality according to use of corticosteroids megadoses.

Results
Of a total of 14,921 patients, corticosteroids were used in 5,262 (35.3%). Of them, 2,216 (46%) specifically received megadoses. Age was a factor that differed between those who received megadoses therapy versus those who did not in a significant manner (69 years [IQR 59–79] vs 73 years [IQR 61–83]; p < .001). Radiological and analytical findings showed a higher use of megadoses therapy among patients with an interstitial infiltrate and elevated inflammatory markers associated with COVID-19. In the univariate study it appears that steroid use is associated with increased mortality (OR 2.07 95% CI 1.91–2.24 p < .001) and megadose use with increased survival (OR 0.84 95% CI 0.75–0.96, p 0.011), but when adjusting for possible confounding factors, it is observed that the use of megadoses is also associated with higher mortality (OR 1.54, 95% CI 1.32–1.80; p < .001). There is no difference between megadoses and low-dose (p .298). Although, there are differences in the use of megadoses versus low-dose in terms of complications, mainly infectious, with fewer pneumonias and sepsis in the megadoses group (OR 0.82 95% CI 0.71–0.95; p < .001 and OR 0.80 95% CI 0.65–0.97; p < .001) respectively.

Conclusion
There is no difference in mortality with megadoses versus low-dose, but there is a lower incidence of infectious complications with glucocorticoid megadoses.
User experiences of a mobile phone-based health information and surveillance system (mHISS): A case of caregivers of children under-five in rural communities in Ghana
Authors: Acquah-Gyan Emmanuel , Acheampong Princess Ruhama , Mohammed Aliyu , Adjei Timothy Kwabena , Agyapong Emmanuel , Twumasi-Ankrah Sampson , Sylverken Augustina , Owusu Michael , Owusu-Dabo Ellis 
Published: January 2022

Background
The rapid advancement of mobile technology has fueled the use of mobile devices for health interventions and for improving healthcare provision in underserved communities. Despite the potential of mHealth being used as a health information and surveillance tool, its scale-up has been challenging and, in most cases, unable to advance beyond the pilot stage of implementation. The purpose of this study was to explore user experiences of a mobile phone-based interactive voice response (IVR) system among caregivers of children under-five in rural communities in the Asante Akim North District of Ghana.

Methods
The study adopted an exploratory design. A convenience sampling technique was used to recruit 35 participants who had used an IVR system for at least six months for the study. About 11 in-depth interviews and three focus group discussions were conducted among participants using a semi-structured interview guide. Thematic content analysis was utilized for the analysis of data in this study.

Result
The system was found to be acceptable, and the attitude of caregivers towards the system was also positive. The study discovered that the mobile phone-based Health Information and Surveillance System (mHISS) was useful for improving access to healthcare, communicating with health professionals, served as a decision support system, and improved caregivers’ awareness about self-management of childhood illnesses. Poor network quality, unstable electricity power supply, and dropped/cut calls served as significant barriers to using the mHISS system.

Conclusion
The mHISS system was generally acceptable and could help improve access to healthcare and identify children with severe health conditions during outbreaks of diseases.
Relationship between hypertension and non-obstructive coronary artery disease in chronic coronary syndrome (the NORIC registry)
Authors: Berge Caroline A. , Eskerud Ingeborg , Almeland Elise B. , Larsen Terje H. , Pedersen Eva R. , Rotevatn Svein , Lønnebakken Mai Tone 
Published: January 2022

Background
The burden of non-obstructive coronary artery disease (CAD) in the society is high, and there is currently limited evidence-based recommendation for risk stratification and treatment. Previous studies have demonstrated an association between increasing extent of non-obstructive CAD and cardiovascular events. Whether hypertension, a modifiable cardiovascular risk factor, is associated with extensive non-obstructive CAD in patients with symptomatic chronic coronary syndrome (CCS) remains unclear.

Methods
We included 1138 patients (mean age 62±11 years, 48% women) with symptomatic CCS and non-obstructive CAD (1–49% lumen diameter reduction) by coronary computed tomography angiography (CCTA) from the Norwegian Registry for Invasive Cardiology (NORIC). The extent of non-obstructive CAD was assessed as coronary artery segment involvement score (SIS), and extensive non-obstructive CAD was adjudicated when SIS >4. Hypertension was defined as known hypertension or use of antihypertensive medication.

Results
Hypertension was found in 45% of patients. Hypertensive patients were older, with a higher SIS, calcium score, and prevalence of comorbidities and statin therapy compared to the normotensive (all p<0.05). There was no difference in the prevalence of hypertension between sexes. Univariable analysis revealed a significant association between hypertension and non-obstructive CAD. In multivariable analysis, hypertension remained associated with extensive non-obstructive CAD, independent of sex, age, smoking, diabetes, statin treatment, obesity and calcium score (OR 1.85, 95% CI [1.22–2.80], p = 0.004).

Conclusion
In symptomatic CCS, hypertension was associated with extensive non-obstructive CAD by CCTA. Whether hypertension may be a new treatment target in symptomatic non-obstructive CAD needs to be explored in future studies.

Clinical trial registration
ClinicalTrials.gov: Identifier NCT 04009421.
Prevalence of targeted therapy-related genetic variations in NSCLC and their relationship with clinicopathological characteristics
Authors: Li Fanghua , Ye Peng , Cai Peiling , Dong Dandan , Zhang Yihao , Yang Yue , Sun Xingwang 
Published: January 2022

Background
Non-small cell lung cancer (NSCLC) is the most common cancer type in China. Targeted therapies have been used to treat NSCLC for two decades, which is only suitable for a subgroup of patients with specific genetic variations. The aim of this study was to investigate the prevalence of genetic variations leading to sensitivity or resistance to targeted therapies in NSCLC, and their relationship with clinicopathological characteristics of the patients.

Methods
Tumor samples were collected from 404 patients who were diagnosed to have NSCLC and underwent surgery, transthoracic biopsy, bronchoscopy biopsy, or pleural aspiration in Sichuan Provincial People’s Hospital from January 2019 to March 2020. Commercial amplification-refractory mutation system kits were used to detect targeted therapy-related genetic variations in those tumor samples. The prevalence of genetic variations and their relationship with patient clinicopathological characteristics were analyzed using statistical software, followed by subgroup analysis.

Results
In all, 50.7% of the NSCLC patients had sensitive genetic variations to anti-EGFR therapies, and 4.9% of those patients had co-existing resistant genetic variations. Fusions in ALK, ROS1, or RET were found in 7.7% of the patients, including 2 patients with co-existing EGFR exon 19 deletion or L858R. EGFR exon 19 deletion and L858R were more common in female patients and adenocarcinoma. Further subgroup analysis confirmed the observation in female patients in adenocarcinoma subgroup, and in adenocarcinoma in male patients. In addition, smokers were more likely to have squamous cell carcinoma and KRAS mutation and less likely to have EGFR L858R, which were also confirmed after standardization of gender except KRAS mutations.

Conclusion
Nearly half of the NSCLC patients were eligible for anti-EGFR treatments. In NSCLC, female gender and adenocarcinoma may indicate higher chance of EGFR exon 19 deletion or L858R, and smoking history may indicate squamous cell carcinoma and EGFR L858R.
Promoting the use of a self-management strategy among novice chiropractors treating individuals with spine pain: A mixed methods pilot clustered-clinical trial
Authors: Eilayyan Owis , Thomas Aliki , Hallé Marie-Christine , Tibbles Anthony C. , Jacobs Craig , Ahmed Sara , Schneider Michael J. , Al Zoubi Fadi , Lee Joyce , Myrtos Danny , Long Cynthia R. , Bussieres Andre 
Published: January 2022

Background
The uptake of Self-Management Support (SMS) among clinicians is suboptimal. To date, few studies have tested knowledge translation (KT) interventions to increase the application of SMS in chiropractic teaching clinics.

Study objective
Evaluate the feasibility of implementing a KT intervention to promote the use of a SMS strategy among chiropractic interns, their supervisors, and individuals with spine pain compared to controls.

Methods
Mixed methods pilot clustered-clinical trial. Clusters of 16 Patient Management Teams were allocated to a complex KT intervention (online and workshop training). Primary feasibility outcomes for clinicians, interns and patients were rates of recruitment, retention, and adherence to protocol. A nominal group technique and interviews were used to seek end-users’ views on the implementation process, and generate possible solutions.

Results
In total, 16 (84%) clinicians, 65 (26%) interns and 42 patients agreed to participate. All clinicians in the intervention group completed all KT intervention components, 23 interns (85%) completed the online training and 14 interns (51.8%) attended the workshop training. All clinicians in the intervention and seven (78%) in the control group completed all outcome measures at baseline and 6-month follow-up, while 15 (55.6%) and 23 (60.5%) interns in the intervention and control groups completed the questionnaires at baseline and 6-month follow-up, respectively. Among patients, 10 (52.6%) and 12 (52.2%) in the intervention and control groups respectively completed the questionnaires at the end of the study. Based on interview findings, solutions to improve the feasibility of conducting a full trial include: making SMS a part of the internship, changing the time of introducing the study to the interns, and having more training on SMS.

Conclusion
Recruitment and retention of chiropractic interns and patients for a larger implementation trial in a single outpatient teaching clinic may be challenging.
Susceptibilidade à liquefacção de uma areia dunar avaliada em ensaios laboratoriais com medição de velocidades de ondas sísmicas
Authors: Rocha José , Fonseca António 
Published: January 2022

Neste trabalho avaliou-se a susceptibilidade à liquefacção de uma areia dunar proveniente de Ain Beniam, em Argel, Argélia, onde, em 2003, ocorreu o sismo Boumerdès que causou graves danos a nível estrutural, muitos deles associados a este fenómeno.
Estes estudos têm vindo a ser efectuado no LabGeo da FEUP, incorporando ensaios de compressão isotrópica e edométrica, assim como ensaios triaxiais cíclicos, não drenados, tendo-se utilizado transdutores piezoeléc tricos, do tipo bender-extender elements, que permitiram a medição de ondas de compressão (“P”) e distorcio nais ou de corte (“S”). O conjunto de amostras ensaiadas foi preparado com recurso à técnica de apiloamento com solo húmido (“moist tamping”), para um determinado valor do teor em água, mas com variações do índice de vazios, de forma a ser possível definir quais as condições de compacidade limite para a ocorrência do fenómeno em estudo.
Desta forma foi possível avaliar a susceptibilidade à liquefacção estática e cíclica, para diferentes condições de estado, utilizando diferentes critérios, tal como o da composição física do material, o da condição de estado pela teoria dos estados críticos, e correlacionando a acção com a resistência em acções cíclicas por via da velocidade normalizada das ondas distorcionais sísmicas.
Selective Interruption of Auditory Interhemispheric Cross Talk Impairs Discrimination Learning of Frequency-Modulated Tone Direction But Not Gap Detection and Discrimination
Authors: Saldeitis Katja , Jeschke Marcus , Michalek Annika , Henschke Julia U. , Wetzel Wolfram , Ohl Frank W. , Budinger Eike 
Published: January 2022

Functional hemispheric lateralization is a basic principle of brain organization. In the auditory domain, the right auditory cortex (AC) determines the pitch direction of continuous auditory stimuli whereas the left AC discriminates gaps in these stimuli. The involved functional interactions between the two sides, mediated by commissural connections, are poorly understood. Here, we selectively disrupted the interhemispheric cross talk from the left to the right primary AC and vice versa using chromophore-targeted laser-induced apoptosis of the respective projection neurons, which make up 6–17% of all AC neurons in Layers III, V, and VI. Following photolysis, male gerbils were trained in a first experimental set to discriminate between rising and falling frequency-modulated (FM) tone sweeps. The acquisition of the task was significantly delayed in lesioned animals of either lesion direction. However, the final discrimination performance and hit rate was lowest for animals with left-side lesioned commissural neurons, demonstrating that also information from the left AC is relevant for FM direction learning. Photolysis after successful learning did not affect the retrieval of the learned task, indicating that the disruption during learning was not because of a general functional impairment. In a second experimental set, the gerbil's ability to detect and discriminate small silent gaps of varying length within FM sweeps was tested. This ability was also preserved after interhemispheric disruption. Taken together, interhemispheric communication between the left and right AC is important for the acquisition of FM tone direction learning but not for its retrieval and for gap detection and gap duration discrimination.SIGNIFICANCE STATEMENTHemispheric lateralization of neuronal functions such as speech and music processing in humans are common throughout the brain; however, the involved interhemispheric interactions are ill-defined. Here, we show that the selective photolytic disruption of auditory cortical commissural connections in rodents impairs the acquisition but not retrieval of a frequency-modulated tone direction discrimination task. The final discrimination performance and hit rate was lowest for animals with lesioned left-to-right-side projections; thus, although right auditory cortex is dominant, left auditory cortex is also relevant for learning this task. The detection and discrimination of small gaps within the tone sweeps remain intact, suggesting a pathway for the processing of these temporal structures, which could be independent from the lesioned interhemispheric cross talk.
Retirement Planning: Charles Warren Callister, the Neighborhood Unit, and the Architecture of Community at Rossmoor and Heritage Village
Authors: Lasner Matthew Gordon 
Published: January 2022

Abstract
In the early 1960s, amid affluence, loneliness, and increasing longevity, a new type of community appeared in the United States: the “active-retirement complex,” with thousands of houses and/or apartments and an unprecedented range of communal facilities. Though such communities were instantly popular, skeptics likened the first examples to internment camps, and to deflect such critiques, developers like Ross Cortese began to prioritize design. In Retirement Planning: Charles Warren Callister, the Neighborhood Unit, and the Architecture of Community at Rossmoor and Heritage Village, Matthew Gordon Lasner describes how Cortese hired acclaimed San Francisco Bay Area architect Charles Warren Callister, known for his innovative private and ecclesiastical commissions, to design a new retirement community known as Rossmoor, located in the East Bay suburb of Walnut Creek. Long interested in housing reform, Callister attempted to serve the needs of seniors, especially their needs for community and activity, by employing a village plan and arranging the housing in “neighborhoods” around clustered courtyards, both at Rossmoor and at a later project, Heritage Village in Connecticut. Lasner’s study examines the experiences of residents of Callister’s complexes to determine whether this approach, which was rooted in theory rather than gerontological research, “worked” as intended.
Effect of induction moment on Bradyrhizobium-soybean (Glycine max) interaction
Authors: Nápoles-García Maria Caridad , Costales-Menéndez Daimy , Hernández-Forte Ionel , Pérez-Pérez Reneé , Wegria Guilleaume , Cabrera-Pino Juan Carlos 
Published: January 2022

Introduction. Legume nodulation is regulated by the exchange of molecular signals between the plant and rhizobia. The bacterial nodulation genes are activated by flavonoids present in root exudates. As a result of this activation, the Nod factors are synthesized, which in turn participate in the morphogenesis and function of the nodules. It is then possible to regulate the induction of Nod factors and other signals related to the nodulation process, during the inoculants production. Objective. To determine if the moment to induce the nodulation genes in Bradyrhizobium inoculants affects the synthesis of compounds related to the nodulation process and its interaction with soybean plants. Materials and methods. The research was developed in Rizobacter S.A., Argentina and Fyteko S.A. laboratories, Belgium, and in a plant growth chamber of the first one, during May-June of 2017. Two Bradyrhizobium strains were induced with daidzein in three moments. The signals produced by the strains and the biological effect in soybean plants were studied. Results. Differences were detected in the molecules produced by the bacteria, but it did not affect the growing and plants nodulation related to the different moments of induction. Conclusion. The metabolites excreted by Bradyrhizobium changed with strain and induction moment, although the latter did not affect nodulation or soybean plants growth.
Subpoblaciones morfométricas de espermatozoides epididimarios del venado de cola blanca (Odocoileus virginianus peruvianus)
Authors: Cucho Hernán , Nina Gregorio , Meza Aydee , Ccalta Ruth , Ordóñez César , Valverde Abarca Anthony 
Published: January 2022

Introducción. El estudio de la morfometría espermática del venado cola blanca (Odocoileus virginianus peruvianus) permite caracterizar las células espermáticas de esta especie con propósitos de conservación. Objetivo. Determinar las subpoblaciones espermáticas según la morfometría de los espermatozoides epididimarios del venado de cola blanca, con un sistema CASA-Morph. Materiales y métodos. El estudio se desarrolló en el segundo semestre 2016, en la Universidad Nacional de San Antonio Abad del Cusco, Perú. En muestras de semen obtenidas del extremo caudal del epidídimo de dos venados (dos y cuatro dientes), se determinó con base en el sistema CASA-Morph, Integrated Semen Analysis System (ISAS®v1): la longitud, anchura, área, perímetro, elipticidad, elongación, regularidad y rugosidad de la cabeza del espermatozoide, también, la anchura, área, distancia y ángulo de inserción de la pieza intermedia. Se realizó un análisis de componentes principales (PCA) y se aplicó el modelo no jerárquico k-medias para determinar el número óptimo de clústeres. Resultados. Las variables morfométricas se distribuyeron en cinco PCA: elipticidad, tamaño, circularidad, ángulo de inserción de la pieza intermedia y anchura de la pieza intermedia, que explicaron un 81,24 % de la varianza total. El análisis de clústeres determinó cuatro subpoblaciones (SP), la SP1 agrupó células grandes, alargadas con alta elongación y elipticidad (21,76 %), la SP2 compuesta por espermatozoides de tamaño pequeño y delgados tanto en la cabeza como en la pieza intermedia (37,7 %), la SP3 se relacionó con la presencia de células alargadas con valores altos de anchura de la pieza intermedia, elipticidad y elongación (17,7 %), y la SP4 agrupó espermatozoides de tamaño intermedio de la cabeza y de la pieza intermedia (22,84 %). Conclusiones. La determinación de cuatro subpoblaciones espermáticas en el semen de venado cola blanca puede ser la base de programas de reproducción asistida de esta especie.