bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Influence of Biosurface Design on the Interaction between the Regulatory Peptide RS1‐reg and ODC1 Reveals a Membrane‐Dependent Affinity Increase
Authors: Keller Thorsten , Koepsell Hermann , Groll Jürgen 
Published: June 2022

AbstractThe regulatory solute carrier protein, family 1, member 1 (RS1) modulates via its N‐terminal domain RS1‐reg the activity of Na+–d‐glucose cotransporter 1 (SGLT1) and thereby the glucose uptake in the small intestine by blocking the release of SGLT1‐containing vesicles at the trans‐Golgi network (TGN). The antidiabetic activity of RS1 is mediated by ornithindecarboxylase 1 (ODC1), catalyzing the conversion of ornithine to putrescine. Putrescine can bind to a buddying protein complex for SGLT1‐containing vesicles at the membrane of the TGN, triggering vesicle release. In this report, a first in‐depth analysis of the important binding process between ODC1 and RS1‐reg for regulating glucose uptake in the human organism is described by comparing results from the surface‐based methods, “surface plasmon resonance” (SPR) and “surface acoustic wave” (SAW) with findings by isothermal titration calorimetry (ITC). In cases of SAW and SPR, three different assay surface setups are compared, resulting in small but significant differences in KD values for different surfaces. Noteworthy, an affinity increase by the factor of about 100 for the interaction is detected and herewith described for the first time in the presence of biological membranes that may be relevant in vivo for the biological function of RS1 and future bespoken antidiabetic drug development.
Improving and Quantifying Surface Charge Density via Charge Injection Enabled by Air Breakdown
Authors: Wu Huiyuan , Fu Shaoke , He Wencong , Shan Chuncai , Wang Jian , Du Yan , Du Shihe , Li Bangxing , Hu Chenguo 
Published: June 2022

AbstractThe modification of triboelectric materials is an important means to improve the output performance of triboelectric nanogenerator (TENG), and the surface charge or ion implantation is an effective way among many modification methods. However, the output enhancement via optimizing triboelectric materials is still limited. Herein, a fast surface charge injection technique based on air breakdown effect is reported, which utilizes an excitation circuit to realize the directional accumulation of charge. Consequently, the output charge density of the Polyimide (PI) film after charge injection reaches 880 µC m‐2, which is the highest of the series of modified triboelectric materials. Moreover, a novel charge transfer mechanism with electrostatic induction competition is proposed, in which significant difference between surface charge density and output charge density is highlighted clearly. Meanwhile, the method of quantifying surface charge density is further given. This work provides a more effective method for the modification of dielectric materials and also offers an important insight towards the charge transfer mechanism in TENG.
Integrated Bending Actuation and the Self‐Sensing Capability of Poly(Vinyl Chloride) Gels with Ionic Liquids
Authors: Liu Zhiwei , Li Beibei , Liu Ying Dan , Liang Yongri 
Published: June 2022

AbstractSoft actuation materials often only perform an actuation function, and do not achieve the function of self‐sensing. In this work, the polyvinyl chloride (PVC) gels are prepared with a plasticizer of dibutyl adipate (DBA) and small amount of imidazolium type ionic liquids (ILs), and are demonstrated that the PVC/DBA/ILs gels deliver the integrated bending actuation and capacitance pressure self‐sensing capability. The bending actuation performances and sensing behavior of PVC/DBA/ILs are related to the migrability of movable ions from ILs, which are dependent on the dissociation of anions and cations of ILs, and the concentration of ILs. Among the ILs, the PVC/DBA gel with 3.3 wt% 1‐allyl‐3‐methylimidazolium bis ((trifluoromethyl)sulphonyl) imide (P/[AMIM]NTF2 (3.3 wt%)) exhibits best bending displacement of 6.6 mm (corresponding to 24° of bending angle) at 7.2 kV (180 V mm−1 of nominal electric field). In addition, the P/[AMIM]NTF2 (3.3 wt%) exhibits 0.42 kPa–1 capacitance pressure sensitive in the pressure range 0 to 2.2 kPa, and a sudden change in capacitance in the pressure range 2.2–2.7 kPa with 47.5 kPa–1 of sensitivity. The results can provide a new idea for developing integrated sensing and actuation functions of electroactive dielectric polymer gels.
Tuning Ion/Electron Conducting Properties at Electrified Interfaces for Practical All‐Solid‐State Li–Metal Batteries
Authors: Guo Junze , Zhang Weidong , Shen Zeyu , Mao Shulan , Wang Xinyang , Zhang Shichao , Zhang Jiahui , Lu Yingying 
Published: June 2022

AbstractPoly(ethylene oxide) (PEO) based solid‐state electrolytes with good chemical stability against Li–metal, provide a promising solution for practical all solid‐state Li–metal batteries (ASSLMBs). However, the risk of short circuit using thin PEO under semi‐molten state and the oxidative decomposition of PEO by cathodes under high voltage hinder the practical application of PEO‐based ASSLMBs. Here, it is found that by readjusting the Li+ and e– conductivity at anode/cathode interface by introducing Nanodiamonds (NDs) into PEO electrolytes can greatly improve the electrochemical performance of PEO‐based batteries. Under the mediation of high modulus and insulative NDs, the lifespan of Li symmetric cells can increase by 30 times at 0.8 mA cm–2, and high‐voltage Li/LiCoO2 cells show excellent capacity retention under practical testing conditions (50 µm Li and 30 µm PEO electrolyte).
Synergism of Flame‐Retardant, Self‐Healing, High‐Conductive and Polar to a Multi‐Functional Binder for Lithium–Sulfur Batteries
Authors: Liu Mingliang , Chen Peng , Pan Xinchen , Pan Shencheng , Zhang Xiang , Zhou Yan , Bi Min , Sun Jingwen , Yang Shaolin , Vasiliev Aleksandr L. , Kulesza Pawel J. , Ouyang Xiaoping , Xu Jianbo , Wang Xin , Zhu Junwu , Fu Yongsheng 
Published: June 2022

AbstractIn this work, a multifunctional binder with self‐healing, flame retardant, high conductivity, and abundant polar groups is prepared by the free radical polymerization method and applied to lithium–sulfur (Li‐S) batteries to achieve high safety and exceptional electrochemical performance. The self‐healing characteristic of binder induced by intermolecular hydrogen bonds and SS dynamic covalent bonds can repair volume expansion cracks. The polar groups and excellent conductivity endue binder with strong chemisorption on polysulfides and fast charge transportation, which can effectively inhibit the shuttle effect and accelerate polysulfides redox kinetics. More important, the considerable flame retardant performance of binder can improve the safety of the LiS batteries. As a result, the LiS cells using FHCP binder deliver an outstanding cycle stability of a high‐capacity retention rate of 85% after 100 cycles at 0.2 C, and a high reversible area specific capacity of 5.25 mAh cm–2 at a sulfur loading of 4.72 mg cm–2 and a correspondingly lean electrolyte condition (E/S ratio = 6 µL mg–1).
Recent Progress in 2D Inorganic/Organic Charge Transfer Heterojunction Photodetectors
Authors: Han Jiayue , Wang Fakun , Han Song , Deng Wenjie , Du Xiaoyang , Yu He , Gou Jun , Wang Qi Jie , Wang Jun 
Published: June 2022

Abstract2D materials possess superior optoelectronic properties, such as ultrahigh mobility and broadband photoresponse, making them one of the most vital platforms for diversified photodetectors. However, atomic thickness 2D materials usually suffer from intrinsic low absorption. To promote the photodetector performance, a feasible method is to integrate the 2D materials with low‐cost, flexible, and tunable organics that form a charge transfer (CT) heterojunction. As results, in‐depth multifunctional CT 2D‐inorganic/organic detector exhibits extended functions such as low‐power consumption, in‐memory detection, and optical‐bio synapse to meet the demand of contemporary photonic cell. Particularly, the progresses in wafer‐scale monocrystal of both 2D and organic materials render vast potential applications with operation frequencies ranging from ultraviolet to terahertz. Here, the recent advances of 2D‐inorganic/organic CT photodetectors are comprehensively reviewed by several classifications. Future developments and applications in optical biology, synapsis, and machine vision are also highlighted.
Brain Co‐Delivery of Temozolomide and Cisplatin for Combinatorial Glioblastoma Chemotherapy
Authors: Zou Yan , Wang Yibin , Xu Sen , Liu Yanjie , Yin Jinlong , Lovejoy David B. , Zheng Meng , Liang Xing‐Jie , Park Jong Bae , Efremov Yuri M. , Ulasov Ilya , Shi Bingyang 
Published: June 2022

AbstractGlioblastoma (GBM) is an intractable malignancy with high recurrence and mortality. Combinatorial therapy based on temozolomide (TMZ) and cisplatin (CDDP) shows promising potential for GBM therapy in clinical trials. However, significant challenges include limited blood–brain‐barrier (BBB) penetration, poor targeting of GBM tissue/cells, and systemic side effects, which hinder its efficacy in GBM therapy. To surmount these challenges, new GBM‐cell membrane camouflaged and pH‐sensitive biomimetic nanoparticles (MNPs) inspired by the fact that cancer cells readily pass the BBB and localize with homologous cells, are developed. This study's results show that MNPs can efficiently co‐load TMZ and CDDP, transport these across the BBB to specifically target GBM. Incorporation of pH‐sensitive polymer then allows for controlled release of drug cargos at GBM sites for combination drug therapy. Mice bearing orthotopic U87MG or drug‐resistant U251R GBM tumor and treated with MNPs@TMZ+CDDP show a potent anti‐GBM effect, greatly extending the survival time relative to mice receiving single‐drug loaded nanoparticles. No obvious side effects are apparent in histological analyses or blood routine studies. Considering these results, the study's new nanoparticle formulation overcomes multiple challenges currently limiting the efficacy of combined TMZ and CDDP GBM drug therapy and appears to be a promising strategy for future GBM combinatorial chemotherapy.
Ultra‐Low‐Cost, Crosstalk‐Free, Fast‐Responding, Wide‐Sensing‐Range Tactile Fingertip Sensor for Smart Gloves
Authors: Sinha Anoop Kumar , Goh Guo Liang , Yeong Wai Yee , Cai Yiyu 
Published: June 2022

AbstractSkin‐inspired sensors are all the rage in robotic applications. They take inspiration from the human skin's sensory abilities and use their abilities to sense things like temperature and pressure. Herein, fabrication of ultra‐low‐cost (<$1.5), ultra‐thin, wide range, and crosstalk‐free skin‐inspired tactile sensors is presented. The sensors consist of piezoresistive pressure sensing elements sandwiched between 3D printed silver nanoparticle electrodes on polyimide layers just like the epidermis, dermis, and hypodermis of human skin. The response time of individual sensing nodes is 4 ms which is faster than the response time of the human skin (30–50 ms). The sensors exhibit high sensitivity (1.35 kPa−1), low hysteresis (9.22%), and a wide pressure sensing range (5–600 kPa). The sensor arrays are assembled on the fingertips of a commercial glove to make a smart glove. By combining the sensor information and deep learning, the smart glove is used to identify sharp and blunt objects with a classification accuracy of 95.9% and the direction of applied pressure when touched by an object with a classification accuracy of 97.8%. Furthermore, the smart glove is used to generate pressure maps in real‐time while grabbing six different objects handled by humans in daily life.
A Review: Textile Technologies for Single and Multi‐Layer Tubular Soft Tissue Engineering
Authors: Doersam Anna , Tsigkou Olga , Jones Celina 
Published: June 2022

AbstractIn cell‐free scaffold tissue engineering (TE), an essential prerequisite is the scaffold design to promote cellular activities and tissue formation. The success is greatly dependent upon the nature of the scaffold including the composition, topography, and mechanical performance. Recent TE approaches use textile technologies to create biomimetic and functional scaffolds similar to the extracellular matrix (ECM). The hierarchical architecture of fiber to yarn to fabric allows precise size‐to‐scale design. Moreover, textile technologies offer a high degree of manufacturing precision, reproducibility, and potential industrial scalability. Although research in industry and academia has increased significantly over the past years, current fibrous scaffold designs don't fully exploit the potential and diversity of yarn and fabric structures. This review emphasizes hollow tubular textile‐based scaffolds that aim to replace vasculature and respiratory tissues. The different techniques, that is, electrospinning, weaving, knitting, and braiding are discussed and the effect of the fiber, yarn, and fabric assembly is highlighted. The design of multi‐layer hybrid structures, combining conventional textile techniques and electrospinning can address current challenges. Prospects of structural design in TE scaffold fabrication can anticipate profiled fibers, and complex pattern designs to fully exploit the potential of textile technologies for tissue‐engineered scaffolds.
Microstructure Engineering of Al Doped SrTiO3/TiO2 Heterostructure Nanorod Arrays Boosting Piezo‐Photocatalytic Performances
Authors: Chu Xianqiang , Jiang Xiaoqi , Zhang Hui , Wang Cheng , Huang Fangzhi , Sun Xiaoyu , Li Shikuo 
Published: June 2022

AbstractModulating the charge‐transfer pathway is of great significance for boosting the photocatalytic efficiency of the catalysts. Herein, well‐ordered Al doping SrTiO3/TiO2 heterojunction nanorod arrays (Al‐STO/TiO2 HNRAs) via a two‐step hydrothermal protocol for efficient piezo‐photocatalysis are reported. The piezoelectric field generated by the internal polarization of Al‐STO/TiO2 HNRAs can be tailored by Al doping content, which could help to modulate the migration and separation of charge carriers. The doping of Al also makes the charge lifetime from 1.14 ns increased to 1.76 ns. Under the co‐excitation of ultrasonic and ultraviolet irradiation, the oxidation rate constant of Al‐STO/TiO2 HNRAs can reach 0.037 min−1 for the degradation of Rhodamine B molecules, which was 3.42 times higher than that of the un‐doping sample. The piezo‐potential distribution and charge migration within Al‐STO/TiO2 HNRAs were explored by piezoelectric force microscopy and COMSOL simulation. This work provides a promising solution toward modulating charge carrier migration for boosting photocatalytic activities with the assistance of mechanic vibration.
High‐Resolution Programmable Metasurface Imager Based on Multilayer Perceptron Network
Authors: Gu Ze , Ma Qian , Liu Che , Xiao Qiang , Gao Xinxin , Yan Tao , Miao Long , Li Lianlin , Cui Tie Jun 
Published: June 2022

AbstractIn the data‐driven society, fidelity and accuracy of automatic decisions behind the scene rely fundamentally on a solid data or imaging acquisition system. However, conventional microwave imagers are inadequate relating to their resolution and noise capability, mainly due to the limited aperture size and rigid working principle. Here, a programmable metasurface imager with high‐resolution and anti‐interference performance is proposed. By implementing the structure of multilayer perceptron network in the analog domain, the metasurface‐based microwave imager intelligently adapts to different datasets through illuminating a set of designed scattering patterns that mimic the feature patterns. A prototype imager system working at microwave frequency is designed and fabricated. The accuracy rate rises by 18% under the classification task of MNIST dataset, with a decline in the reconstruction imaging error. The authors experimentally demonstrate that the resolution to distinguish strip patterns goes beyond to one‐fifth of the equivalent wavelength on the target plane.
Oxygen‐Scavenging Effects of Added Ti Layer in the TiN Gate of Metal‐Ferroelectric‐Insulator‐Semiconductor Capacitor with Al‐Doped HfO2 Ferroelectric Film
Authors: Lee Yong Bin , Kim Beom Yong , Park Hyeon Woo , Lee Suk Hyun , Oh Minsik , Ryoo Seung Kyu , Lee In Soo , Byun Seungyong , Shim Doosup , Lee Jae Hoon , Kim Hani , Kim Kyung Do , Park Min Hyuk , Hwang Cheol Seong 
Published: June 2022

AbstractTi layer inserted in the TiN gate electrode effectively scavenges the oxygen in the low‐k interfacial SiO2 of the metal–ferroelectric–insulator–semiconductor (MFIS) capacitors with the ferroelectric Al‐doped HfO2 (HAO) thin film. The scavenging effect increases remanent polarization (Pr) and reduces coercive voltage (Vc) and capacitance equivalent thickness (CET) of the HAO films, particularly when the MFIS capacitor is annealed at 800 °C. Additionally, frequency dispersion of capacitance characteristics and interface trap density (Dit) calculations reveal that actively‐triggered oxygen‐scavenging effects also reduce defect or trap‐induced degradation. The Ti‐inserted MFIS structure exhibits fatigue‐free endurance and relatively low leakage current characteristics as compared to a structure without the Ti scavenging layer in high annealing temperature conditions required for crystallization of the HAO ferroelectric films.
Ordered Mesoporous Intermetallic Trimetals for Efficient and pH‐Universal Hydrogen Evolution Electrocatalysis
Authors: Wang Yanzhi , Lv Hao , Sun Lizhi , Jia Fengrui , Liu Ben 
Published: June 2022

AbstractOrdered intermetallic platinum‐zinc (I‐PtZn) bimetals represent an emerging class of alloy electrocatalysts for water splitting and fuel cell electrocatalysis, but large‐scale commercial implementation has still been hindered by their catalytic activity and stability. Here, ordered mesoporous I‐PtZn bimetals are selectively substituted with 3d transition/main metals, termed MI‐PtZnM trimetals, where M is scandium, vanadium, chromium, manganese, iron, cobalt, nickel, copper, or gallium. It is demonstrated that ordered MI‐PtZnCo trimetals exhibit the best electrocatalytic performance for the hydrogen evolution reaction (HER) in an alkaline media, with a high mass activity of 1.77 A mgpt–1 and specific activity of 3.07 mA cmpt–2. More impressively, this electrocatalyst shows robust electrocatalytic stability with negligible activity decay even after 50 000 cycles. The MI‐PtZnCo trimetals are also highly active and stable for HER electrocatalysis over a wide pH range (neutral and acidic media). Mechanistic studies suggest that Co‐enabled Pt atoms in MI‐PtZn with a more electron‐rich surface, in addition to stable mesoporous and intermetallic structure, synergistically accelerate Tafel kinetics and thus enhance HER activity and stability of MI‐PtZnCo trimetal electrocatalysts.
Emergency care of LGBTQIA+ patients requires more than understanding the acronym
Authors: Hsiang Elaine , Ritchie Amanda M. , Lall Michelle D. , Driver Lachlan , Moll Joel , Sonn Brandon , Totten Vicken Y. , Williams Dustin B. , McGregor Alyson J. , Egan Daniel J. 
Published: June 2022

AbstractEmergency physicians (EPs) frequently deliver care to members of the LGBTQIA+ community in the emergency department. This community suffers from many health disparities important to understand as part of comprehensive care, and these disparities are infrequently discussed in emergency medicine education. Previous data also suggest a need for broader education to increase the comfort of EPs caring for LGBTQIA+ patients. A group of content experts identified key disparities, opportunities for expanded education, and strategies for more inclusive care of LGBTQIA+ patients.
Making emergency medicine accessible for all: The what, why, and how of providing accommodations for learners and physicians with disabilities
Authors: Poffenberger Cori McClure , Coates Wendy C. , Backster Anika , Rotoli Jason 
Published: June 2022

AbstractIndividuals with disabilities comprise a substantial portion of the U.S. population but make up only a small subset of medical students and health care providers. Both the Association of American Medical Colleges and the Accreditation Council for Graduate Medical Education have called for increased diversity in the physician workforce, to more closely represent the U.S. patient population and provide culturally effective care. Yet the barriers to disclosure and inclusion for individuals with disabilities in health care are significant, including attitudinal barriers such as stigma and bias, organizational barriers in policies and procedures, and environmental barriers such as resources and physical space. Lack of experience providing accommodations and a lack of knowledge of both what is legally required and what is possible also prevent programs from creating access. Realizing inclusion for individuals with disabilities in a diverse workforce requires emergency medicine programs to be proactive and deliberate in their approach to recruiting, accommodating, and retaining students, residents, and faculty with disabilities. Such efforts are likely to provide benefits that extend beyond those who receive the accommodations.
Pb (II) and Hg (II) thiosemicarbazones for inhibiting the broad‐spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant system
Authors: Ibrahim Ahmed B. M. , Mahmoud Ghada Abd‐Elmonsef , Cordes David B. , Slawin Alexandra M. Z. 
Published: June 2022

Pb (II) and Hg (II) ions were reacted in aqueous solution with two tridentate thiosemicarbazones, resulting in four complexes {[Pb(L1)2] 1, [Pb(L2)2] 2, [Hg(L1)2] 3, and [Hg(L2)2] 4; HL1 = 4‐(4‐nitrophenyl)‐1‐[(pyridin‐2‐yl)methylene]thiosemicarbazide and HL2 = 4‐(2‐chlorophenyl)‐1‐[(pyridin‐2‐yl)methylene]thiosemicarbazide}. The solid‐state structures of complexes 2 and 3 were determined by X‐ray crystallography, which also confirmed the monobasic tridentate NNS nature of the ligands, and the octahedral coordination geometry around the metal centers. Complexes 1–4 exhibited high antifungal activity against the pathogen Cladosporium sphaerospermum; all four complexes give rise to a reduction in the fungal dry mass and sugar consumption. Complexes 2 and 4 that inhibited C. sphaerospermum growth at the concentration of 1.8 mM are more efficient inhibitors than the free ligand and metal ions. Further, the complexes gave varied values of the fungal total antioxidants (TA), superoxide dismutase (SOD), and catalase (CAT) activities dependent on their concentrations.