bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upaya Guru PAI dalam Menanggulangi Kenakalan Siswa di MA Bahrul Ulum Tambakberas Jombang
Authors: Aziz Isnan , Waslah Waslah , Wardani Dian Kusuma 
Published: April 2022

The main problem of this thesis is about the delinquency of students at Madrasah Aliyah Bahrul Ulum Tambakberas Jombang, aiming to find out the efforts of teachers in overcoming student delinquency at Madrasah Aliyah Bahrul Ulum Tambakberas Jombang. The research focus in this thesis is 1) How are the efforts of PAI teachers in dealing with student delinquency at Madrasah Aliyah Bahrul Ulum, 2) how are the factors that support and hinder the efforts of Pai teachers in overcoming delinquency of students at Madrasah Aliyah Bahrul Ulum. This research is a qualitative field research that examines the Efforts of Islamic Religious Education Teachers in Overcoming Student Delinquency at Madrasah Aliyah Bahrul Ulum Tambakberas Jombang. This type of research is qualitative research and uses a descriptive analysis approach. The results of this study are that the results of observations, fields, interviews related to the topic of determination, with reference to, the forms of delinquency of students in Madrasah Aliyah Bahrul Ulum Like; truant, likes to go to school late, does not wear the appropriate uniform for the day, smokes, fights, is busy in class, cheats on exams, does not pay attention to studying, it is difficult to regulate the efforts of PAI teachers in handling delinquency behavior of students at Madrasah Aliyah Bahrul Ullum there are efforts preventive, curative, repressive efforts.
The main problem of this thesis is about the delinquency of students at Madrasah Aliyah Bahrul Ulum Tambakberas Jombang, aiming to find out the efforts of teachers in overcoming student delinquency at Madrasah Aliyah Bahrul Ulum Tambakberas Jombang. The research focus in this thesis is 1) How are the efforts of PAI teachers in dealing with student delinquency at Madrasah Aliyah Bahrul Ulum, 2) how are the factors that support and hinder the efforts of Pai teachers in overcoming delinquency of students at Madrasah Aliyah Bahrul Ulum. This research is a qualitative field research that examines the Efforts of Islamic Religious Education Teachers in Overcoming Student Delinquency at Madrasah Aliyah Bahrul Ulum Tambakberas Jombang. This type of research is qualitative research and uses a descriptive analysis approach. The results of this study are that the results of observations, fields, interviews related to the topic of determination, with reference to, the forms of delinquency of students in Madrasah Aliyah Bahrul Ulum Like; truant, likes to go to school late, does not wear the appropriate uniform for the day, smokes, fights, is busy in class, cheats on exams, does not pay attention to studying, it is difficult to regulate the efforts of PAI teachers in handling delinquency behavior of students at Madrasah Aliyah Bahrul Ullum there are efforts preventive, curative, repressive efforts.
Programa de telessaúde de enfrentamento ao coronavírus no Paraná: relato de experiência de enfermeiras na orientação de bolsistas multiprofissionais
Authors: Cavalheiro Ana Paula Garbuio , Rodrigues Ana Luzia , Da Silva Carla Luiza 
Published: April 2022

Relatar a experiência da atuação de três enfermeiras na orientação de onze acadêmicos bolsistas multiprofissionais em um programa de telessaúde de enfrentamento a COVID-19 no estado do Paraná. A interação se deu totalmente de forma online e ocorreu no período de março a maio de 2020. Os resultados evidenciaram que a telessaúde é uma estratégia inovadora em saúde que contribuiu para a evitabilidade de deslocamento de usuários à procura direta dos serviços de saúde durante a pandemia. Na ótica das orientadoras, os acadêmicos apresentaram fragilidades para o telemonitoramento da COVID-19 e a educação permanente em saúde. A experiência teve a intenção de partilhar a inovação no atendimento multiprofissional da telessaúde no enfrentamento do novo coronavírus e se apresenta como uma inovadora ferramenta tecnológica frente às diversas áreas da saúde.
Analisis Yuridis Cryptocurrrency Dalam Prespektif Hukum Surat Berharga Di Indonesia
Authors: Rahma Noor Eva , Sabrie Hilda Yunita 
Published: April 2022

Abstractâ€” Cryptocurrency as a digital product has grown significantly. Cryptocurrency as a digital currency has been accepted by the world community, with different implementations in each country. Indonesian law regulates cryptocurrency as a commodity product that can be traded on the Futures Exchange. As a commodity, cryptocurrency monitoring is carried out by BAPPEBTI (Commodity Futures Trading Supervisory Agency). The position of cryptocurrency as a commodity is unfortunate by some, who expect cryptocurrencies to be recognized as legal tender as is the case in some countries. Securities law regulates the elements that must be met in order for an object to be recognized as a means of payment. This is also supported by current practices, namely the level of significant fluctuations in cryptocurrencies and the absence of government intervention which makes the government unable to carry out its role as controller. This study aims to determine the position of cryptocurrency in the perspective of Indonesian law. This study uses a type of normative juridical research with a statutory approach and a conceptual approach. The results of the study note that until now cryptocurrency cannot be recognized as a means of payment and is recognized as a commodity.Â Keywords: cryptocurrencies, securities law, means of payment
Perlindungan Hukum Dan Penyelesaian Jaminan Fidusia Terhadap Debitur Cidera Janji Di Masa Pandemi Covid-19
Authors: Agustina Amaliasyifa , Aslamiyah Suwaebatul 
Published: April 2022

Penelitian ini membahas tentang suatu jaminan fidusia dimana debitur melakukan cidera janji atau gagal bayar di Masa Pandemi Covid-19. Tidak dipungkiri di Indonesia, membeli kendaraan bermotor dalam pembayarannya dilakukan secara dicicil perbulan dengan tenor (jangka waktu) yang sesuai dengan kontrak pembelinnya, dan Jaminan yang biasa digunakan dalam hal ini yaitu jaminan fidusia.Â Masa sebelum adanya Covid-19 ini, debitur seringkali banyak yang cidera janji atau gagal bayar di karenakan beberapa faktor dan cara penyelesaian kreditur untuk mengatasinya adalah sesuai perjanjian yang ada penarikan kendaraan bermotor yang dijaminkan dengan fidusia. Bagaimana setelah adanya pandemi Covid-19 tentunya cara penyelesaian akan berbeda dengan kondisi normal pada umumnya, semua aspek terkena dampak dari pandemi Covid-19 ini. Debitur yang seharusnya tidak ada hambatan dalam melakukan pembayaran cicilan, menjadi terhambat bahkan tidak bisa membayar cicilan kendaraan karena terkena dampak dari pandemi ini. Penelitian ini akan bertujuan untuk dapat menghadapi, mengatasi, danÂ menyelesaikan terkait permasalahan debitur cidera janji di masa pandemi Covid -19. Metode penelitian yang digunakan dalam penelitian ini ialah yuridis normatif dengan melakukan deskritif analitis. Penelitian ini diharapkan menjadi acuan, pedoman, dan sumber informasi teruntuk masyarakat yang mengalami di posisi debitur cidera janji dan bahan masukan untuk kreditur.Â Kata Kunci: Perjanjian, Jaminan, debitur. kreditur
Perbandingan Sistem Pemerintahan Presidensial dalam Sistem Ketatanegaraan di Indonesia dan Iran
Authors: Fikri Sultoni , Ukhwaluddin Anang Fajrul 
Published: April 2022

Abstract--This paper describes a comparison related to the presidential government system in the Unitary State of the Republic of Indonesia and the State of the Islamic Republic of Iran. Some of the basic reasons that make the writer interested in discussing presidential government systems are the existence of standard rules or at least oriented to the United States presidential government system, but in practice, the system tends to follow the conditions of the socio-political-cultural structure that exists in each country. While the background why the author chose Indonesia and Iran to be compared, at least based on several factors. First, related to the history of upheaval in each country, Indonesia has experienced a period of reform and Iran has experienced a period of revolution. Second, Indonesia and Iran are both countries with a majority Muslim population, and Iran makes Islamic values ??the basis of state life. Meanwhile, in Indonesia, Islamic values ??are not fully used as the basis of the state, considering that Indonesia is a diverse country in terms of religion and culture. Third, Indonesia and Iran both use a presidential system of government, but Indonesia and Iran can combine the rules of a presidential government system with the conditions of the socio-political-cultural structure that exist in each country. This research is research using the statutory approach, conceptual approach, and comparative approach. As a result, there are differences in the implementation of presidential government systems in Indonesia and Iran in several indicators. This is very reasonable because the system of government in a country must adapt to the socio-political historical conditions that exist in both Indonesia and Iran.
Indonesia, Iran, presidential system.
Coupled Heat and Flow Analysis Inside a Diversion-Type Gas Heater With Vertical Guide Plate Structure
Authors: Guo Yun , Zhang Xuning , Zhou Zhongwei 
Published: April 2022

In the natural gas heating process, the cylinder-type heater using water as an intermediate heating medium is the most extensively used. The heat exchange rate between the heating medium water and the fire and gas tubes in the great-capacity cylinder appears to be the most important element affecting a gas heater’s thermal efficiency. The water heat flow field within a new diversion-type gas heater with vertical guide plate design is described in this paper. In contrast to prior research that concentrated on natural convection heat transfer in medium water, the radiation impact is included. The discrete-ordinate model was utilized to build a 2-D combined natural convection and participating medium radiation heat transfer model, which was solved using the finite volume technique with unstructured body-fitted grids. First, experimental data were used to validate the numerical model. The coupled heat flow fields with vertical guide plates of various heights were then analyzed. The numerical findings reveal that utilizing a vertical guide plate structure, the proportion of radiation heat transfer in the total heat transfer rate reaches 25.1%, indicating that water radiation cannot be ignored. The vertical guide plate structure might help to create a well-organized flow pattern in the cylinder, which would improve natural convection heat transfer while having no influence on water radiation. Installing a vertical guide plate with a height of 550 mm and a thickness of 5 mm can lower the overall heat transfer rate in the convective tube bundle by 2.04%. In China, this technique has been given a patent.
Prognostic and Diagnostic Values of Semaphorin 5B and Its Correlation With Tumor-Infiltrating Immune Cells in Kidney Renal Clear-Cell Carcinoma
Authors: Ding Junping , Zhao Shubin , Chen Xianhua , Luo Changjun , Peng Jinjian , Zhu Jiantan , Shen Yongqi , Luo Zhou , Chen Jianlin 
Published: April 2022

Background: Semaphorin 5B (SEMA5B) has been described to be involved in the development and progression of cancer. However, the potential diagnostic and prognosis roles and its correlation with tumor-infiltrating immune cells in KIRC have not been clearly reported yet.Methods: The mRNA level of SEMA5B was analyzed via the TCGA and GTEx database as well as the CCLE dataset and verified by GSE53757 and GSE40435 datasets. Meanwhile, the protein level of SEMA5B was analyzed by CPTAC and validated by HPA. The diagnostic value of SEMA5B was analyzed according to the TCGA database and validated by GSE53757, GSE46699, and GSE11024 + GSE46699 datasets. Then, the survival analysis was conducted using GEPIA2. R software (v3.6.3) was applied to investigate the relevance between SEMA5B and immune checkpoints and m6A RNA methylation regulator expression. The correlation between SEMA5B and MMRs and DNMT expression and tumor-infiltrating immune cells was explored via TIMER2. Co-expressed genes of SEMA5B were assessed by cBioPortal, and enrichment analysis was conducted by Metascape. The methylation analysis was conducted with MEXPRESS and MethSurv online tools. Gene set enrichment analysis (GSEA) was applied to annotate the biological function of SEMA5B.Results: SEMA5B was significantly upregulated at both the mRNA and protein levels in KIRC. Further analysis demonstrated that the mRNA expression of SEMA5B was significantly correlated with gender, age, T stage, pathologic stage, and histologic grade. High levels of SEMA5B were found to be a favorable prognostic factor and novel diagnostic biomarker for KIRC. SEMA5B expression was shown to be significantly associated with the abundance of immune cells in KIRC. Also, SEMA5B expression was significantly correlated with the abundance of MMR genes, DNMTs, and m6A regulators in KIRC. Enrichment analysis indicated that the co-expressed genes may involve in crosslinking in the extracellular matrix (ECM). GSEA disclosed that SYSTEMIC_LUPUS_ERYTHEMATOSUS and NABA_ECM_REGULATORS were prominently enriched in the SEMA5B low-expression phenotype. Finally, the methylation analysis demonstrated a correlation between hypermethylation of the SEMA5B gene and a poor prognosis in KIRC.Conclusion: Increased SEMA5B expression correlated with immune cell infiltration, which can be served as a favorable prognostic factor and a novel diagnostic biomarker for KIRC.
Genetic Basis of Dorper Sheep (Ovis aries) Revealed by Long-Read De Novo Genome Assembly
Authors: Qiao Guoyan , Xu Pan , Guo Tingting , Wu Yi , Lu Xiaofang , Zhang Qingfeng , He Xue , Zhu Shaohua , Zhao Hongchang , Lei Zhihui , Sun Weibo , Yang Bohui , Yue Yaojing 
Published: April 2022

Dorper sheep (Ovis aries) (DPS), developed in the 1930s by crossing Dorset Horn and Blackhead Persian sheep in South Africa, is a world-famous composite breed for mutton production. The genetic basis underlying this breed is yet to be elucidated. Here, we report the sequencing and assembly of a highly contiguous Dorper sheep genome via integration of Oxford Nanopore Technology (ONT) sequencing and Hi-C (chromatin conformation capture) approaches. The assembled genome was around 2.64 Gb with a contig N50 of 73.33 Mb and 140 contigs in total. More than 99.5% of the assembled sequences could be anchored to 27 chromosomes and they were annotated with 20,450 protein-coding genes. Allele-specific expression (ASE) genes of Dorper sheep were revealed through ASE analysis and they were involved in the immune system, lipid metabolism, and environmental adaptation. A total of 5,701 and 456 allelic sites were observed in the SNP and indels loci identified from relevant whole-genome resequencing data. These allelic SNP and INDEL sites were annotated in 1,002 and 294 genes, respectively. Moreover, we calculated the number of variant sites and related genes derived from the maternal and paternal ancestors, revealing the genetic basis of outstanding phenotypic performance of Dorper sheep. In conclusion, this study reports the first reference genome of Dorper sheep and reveals its genetic basis through ASE. This study also provides a pipeline for mining genetic information of composite breeds, which has an implication for future hybrid-breeding practices.
Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis
Authors: Courties Alice , Petit Juliette , Do Ariane , Legris Manon , Kouki Inès , Pigenet Audrey , Sacitharan Pradeep K. , Ehkirch Francois-Paul , Berenbaum Francis , Sellam Jérémie 
Published: April 2022

IntroductionOsteoarthritis (OA) is a whole-joint disease characterized by a low-grade inflammation that is involved in both cartilage degradation and subchondral bone remodeling. Since subchondral bone has a cholinergic innervation and that acetylcholine (Ach) might have an anti-inflammatory effect through the α7 nicotinic Ach receptor (α7nAchR), we aimed (i) to determine the expression of non-neuronal cholinergic system and nicotinic receptor subunits by murine and human osteoblasts, (ii) to address the role of α7nAchR in osteoblastic response to inflammation, and (iii) to study the role of α7nAchR in a spontaneous aging OA model.MethodsPrimary cultures of WT and α7nAchR knock-out mice (Chrna7-/-) murine osteoblasts and of subchondral bone human OA osteoblasts were performed. The expressions of the non-neuronal cholinergic system and of the nAchR subunits were assessed by PCR. In vitro, IL1β-stimulated WT, Chrna7-/-, and human osteoblasts were pretreated with nicotine. At 24 h, expressions of interleukin-6 (IL6) and metalloproteinase-3 and -13 (MMP), RANK-ligand (RANKL), and osteoprotegerin (OPG) were quantified by qPCR and ELISA. Spontaneous aging OA was evaluated and compared between male WT and Chrna7-/- mice of 9 and 12 months.ResultsMurine WT osteoblasts express the main components of the cholinergic system and α7 subunit composing α7nAchR. Nicotine partially prevented the IL1β-induced expression and production of IL6, MMP3, and RANKL in WT osteoblasts. The effect for IL6 and MMP was mediated by α7nAchR since nicotine had no effect on Chrna7-/- osteoblasts while the RANKL decrease persisted. Chrna7-/- mice displayed significantly higher cartilage lesions than their WT counterparts at 9 and 12 months, without difference in subchondral bone remodeling. Human OA osteoblasts also expressed the non-neuronal cholinergic system and α7 subunit as well as CHRFAM7A, the dominant negative duplicate of Chrna7. Nicotine pretreatment did not significantly reduce IL6 and MMP3 production in IL-1β-stimulated human osteoarthritic osteoblasts (n = 4), possibly due to CHRFAM7A.ConclusionCholinergic system counteracts murine osteoblastic response to IL-1β through α7nAchR. Since α7nAchR deletion may limit cartilage degradation during murine age-related OA, enhancing cholinergic system could be a new therapeutic target in OA but may depend on CHRFAM7A expression.
Neutrophil Percentage-to-Albumin Ratio: A Good Parameter for the Evaluation of the Severity of Anti-NMDAR Encephalitis at Admission and Prediction of Short-Term Prognosis
Authors: Tang Yao , Hou Haiman , Li Lanjun , Yong Liuliang , Zhang Shuang , Yan Lulu , Huang Xiaoxue , Wu Jun 
Published: April 2022

ObjectivesThe purpose of this study was to investigate the association of neutrophil percentage-to-albumin ratio (NPAR) with the severity at admission and discharge (short-term prognosis) in patients with anti-N-methyl-D-aspartic acid receptor (NMDAR) encephalitis.MethodsMultivariable logistic regression models such as NPAR were constructed based on univariable regression results. Receiver operating characteristic (ROC) curves, nomograms, and concordance index (c-index) were used to evaluate the efficacy of the models in assessing disease severity at admission and predicting short-term prognosis, validated by bootstrap, Hosmer–Lemeshow goodness-of-fit test, calibration curves, and decision curve analysis.ResultsA total of 181 patients with anti-NMDAR encephalitis diagnosed at the First Affiliated Hospital of Zhengzhou University were included. The results showed that NPAR had good sensitivity and specificity in assessing disease severity at admission and predicting short-term prognosis. The multivariable logistic regression models based on NPAR and other influencing factors had good discrimination, consistency, accuracy, calibration ability, applicability, and validity in assessing the severity at admission and predicting short-term prognosis.ConclusionNPAR has good clinical value in assessing disease severity at admission and predicting short-term prognosis of patients with anti-NMDAR encephalitis.
Epigenetic Regulation of Immune and Inflammatory Responses in Rheumatoid Arthritis
Authors: Chen Qi , Li Hao , Liu Yusi , Zhao Min 
Published: April 2022

PurposeRheumatoid arthritis (RA) is a disease associated with multiple factors. Epigenetics can affect gene expression without altering the DNA sequence. In this study, we aimed to comprehensively analyze epigenetic regulation in RA.MethodsUsing the Gene Expression Omnibus database, we identified a methylation chip, RNA-sequencing, and miRNA microarray for RA. First, we searched for DNA methylation, genes, and miRNAs associated with RA using differential analysis. Second, we determined the regulatory networks for RA-specific methylation, miRNA, and m6A using cross-analysis. Based on these three regulatory networks, we built a comprehensive epigenetic regulatory network and identified hub genes.ResultsUsing a differential analysis, we identified 16,852 differentially methylated sites, 4877 differentially expressed genes, and 32 differentially expressed miRNAs. The methylation-expression regulatory network was mainly associated with the PI3K-Akt and T-cell receptor signaling pathways. The miRNA expression regulatory network was mainly related to the MAPK and chemokine signaling pathways. M6A regulatory network was mainly associated with the MAPK signaling pathway. Additionally, five hub genes were identified in the epigenetic regulatory network: CHD3, SETD1B, FBXL19, SMARCA4, and SETD1A. Functional analysis revealed that these five genes were associated with immune cells and inflammatory responses.ConclusionWe constructed a comprehensive epigenetic network associated with RA and identified core regulatory genes. This study provides a new direction for future research on the epigenetic mechanisms of RA.
Efficacy and Safety of Pleural Cryobiopsy vs. Forceps Biopsy for Evaluation of Undiagnosed Pleural Effusion: A Systematic Review and Meta-Analysis
Authors: Giri Mohan , Dai Haiyun , Guo Shuliang , Li Yishi , He Lin , Zhuang Rongjuan 
Published: April 2022

BackgroundPleural cryobiopsy is a novel technique for the diagnosis of pleural pathologies. However, the safety and feasibility of this modality compared to standard forceps for pleural biopsy has not been fully elucidated. This systematic review and meta-analysis aims to establish the efficacy and safety of cryobiopsy for evaluation of undiagnosed pleural effusion.MethodsFor this systematic review and meta-analysis, we searched PubMed, Embase, Scopus, and Web of science databases up to December 16, 2021 to identify relevant articles. We included randomized controlled trials, cohort studies, retrospectives studies and case series that compared pleural cryobiopsy and forceps biopsy. A qualitative assessment was performed using the QUADAS-2 tool.ResultsOf the 365 articles identified by our search, 15 studies were eligible for inclusion. The specimen sizes obtained with cryobiopsy were significantly larger compared with forceps biopsy (Standard mean difference 1.16; 95 % CI: 0.51–1.82; P &lt; 0.01). Furthermore, the cryobiopsy tissue specimens were deeper (OR 2.68; 95 % CI: 1.39–5.16; P &lt; 0.01) and qualitatively better with less crush artifacts (OR 0.06; 95 % CI: 0.01–0.26; P &lt; 0.01). There was no significant difference in diagnostic yield (OR 1.32; 95 % CI: 0.79–2.21; P = 0.29) and mild to moderate bleeding events (OR 1.21; 95 % CI: 0.64–2.29; P = 0.57) between pleural cryobiopsy and forceps biopsy. No publication bias was observed among these studies.ConclusionsCompared to flexible forceps biopsy pleural cryobiopsy obtained larger and deeper tissue specimens with less crush artifacts but does not show superiority for diagnostic yield. Further studies are still needed to verify these findings.