bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Model Sugesti – Imajinasi dengan Media Lagu Bunda terhadap Kemampuan Menulis Cerpen Siswa Kelas XI SMK Swasta YPK Medan
Authors: Oktaviani Dwi , Nila Safina  , Ratna Soraya  
Published: November 2022

This study aims to describe the ability to write short stories using the Suggestion-Imagination learning model with the media song of class XI students of YPK Private Vocational School Medan,
to describe the ability to write short stories using the Suggestion-Imagination learning model with video media for class XI students at YPK Private Vocational School Medan,

To describe whether there is a significant effect on the ability to write short stories using the Suggestion-Imagination learning model with the media of song for class XI students of YPK Private Vocational School Medan. The sample in this study was 60 students. From the results of data processing, the average value of the experimental class was 71.6 while the control class was 65.5. Thus it can be said that the results of learning to write short stories in the experimental class are higher than the control class. After testing the hypothesis, the value of tcount = 3.144 was then adjusted to ttable at a significant level of = 5% with dk = (n1+n2) – 2 = (30+30 – 2) = 58, then obtained a significant level of 5% = 2.002 ( by interpolation). Then compared between tcount and ttable, it was obtained tcount 3.144 > ttable 2.002 so that Ho (Nil Hypothesis) was rejected and Ha (Alternative Hypothesis) was accepted.
Utilization of Terra-MODIS Satellites for Phenomenon Analysis Urban Heat Island in Kalimantan Island
Authors: Absaralita Sabarati  , Jamrud Aminuddin  , RR. Laras Toersilowati  
Published: October 2022

Urban development on the island of Kalimantan in various aspects can in principle increase productivity through the expansion of built-up land. This can have an impact on increasing temperatures in urban areas and lower temperatures around them. This phenomenon is known as urban heat island (UHI). For this reason, it is essential to analyze the phenomenon. The UHI analysis in this study utilizes remote sensing technology using the Terra-MODIS satellite. Terra-MODIS satellite imagery is used to determine land surface temperature (LST) and normalized difference vegetation index (NDVI). The urban areas that are the object of analysis are Pontianak City and Balikpapan. The data used is imagery data from 2001 to 2020. In the province, ESG and NDVI are inversely proportional, but in this study, a condition was produced where the situation was directly proportional. This condition shows that in the analysis of the UHI phenomenon, other factors are needed besides these two parameters, such as humidity and precipitation.
Clinico-Epidemiological Aspects of Cutaneous Lesions in Injecting Drug Users Visiting an Oral Substitution Therapy Centre: A Cross-Sectional Study
Authors: Dhillon Shaminder Singh , Kaur Tejinder , Bala Neeru , Mankaranpreet None 
Published: November 2022

Introduction: Drug abuse has been taking a great toll on the health and well-being of the community for the past few decades. Substance abuse can lead to several cutaneous manifestations both direct injury by the offending drug or the practices of drug usage causing secondary damage to the skin. The early recognition of these signs is of utmost importance to prevent long-term complications.
Objectives: To study the clinical-epidemiological profile of the skin diseases in Injecting Drug Users (IDU) attending Oral Substitution Therapy (OST) center and assess the psychological impact of skin conditions in IDUs attending oral substitution therapy center.
Methods: This cross-sectional observational study involved 100 IDUs enrolled from the OST center who were subjected to brief history taking and clinical and dermoscopic evaluation of skin lesions. Dermatological quality of life index (DLQI), Depression, Anxiety, Stress Scale (DASS), and WHO-QoL questionnaire were used to evaluate the impact of skin lesions on Psycho-social health and quality of life of IDUs.
Results: Cutaneous lesions ranged from track marks to severe ulcerations and scarring. Mucosal lesions also took a toll on several Patients. Patients had varying degrees of anxiety, depression, and mental stress.
Conclusions: Injecting Drug Abusers are prone to acquire Skin diseases due to injury caused by drugs as well as by drug practices adopted and the degree of neglect may worsen these conditions. These cutaneous lesions hamper the quality of life and cause psychosocial disturbances.
Ultrastructural Studies on Lamb Liver with Experimental Bunostomosis
Authors: Kamenov Yotko , Kanchev Kostadin , Mizinska-Boevska Yana 
Published: October 2022

Ultrastructural studies were carried out on liver obtained after the appear- ance of clinical signs of bunostomosis from a group of experimentally infested lambs.
In the hepatocytes of the liver severe changes affecting the endoplasmic reticulum, especially the rough one, and the nucleic chromatin were determined.
The formation of lipid drops into the injured hepatocytes followed the way of a fat degeneration rather than of a lipid infiltration. Both the liver parenchyma and mesenchyma compounds were affected.
This is an evidence of a direct toxic pathogenic action of the etiology agent. These data add to the knowledge of the bunostomosis pathogenesis more information about the leading role of the toxic factor.
Hormonal Status and Bone Health in Bulgarian Adolescents with Secondary Amenorrhoea
Authors: Hristova Diana , Sirakov Milko 
Published: October 2022

A prospective study was conducted including 67 girls with secondary amenorrhoea (excluding cases with PCOS, medical disorders and steroid therapy) and 38 healthy controls. The following indicators were compared between the two groups: serum levels of LH, FSH, estradiol, Ca, P and vitamin D, z- scores for bone mineral density, osteocalcin and β-CrossLaps, and prevalence of vitamin D deficiency. The group with secondary amenorrhoea was additionally subdivided according to the main cause – alimentary deficiency, excessive physical exercise and stress-induced. LH, FSH and estradiol levels were compared between the three subgroups.
Ca, P and vitamin D levels in the studied and the control groups were not significantly different. The following indicators were significantly lower in the studied group compared to the control one: prolactin (291.74 mIU/ml and 336.24 mIU/ml), estradiol (322.43 pmol/ml and 475.45 pmol/ml) and LH (3.79 IU/L and 4.99 IU/L) levels, LH/FSH ratio (0.55 and 0.96) and z-score (−0.48 and 0.47). FSH was significantly higher in the studied group (6.90 IU/L) compared to the control one (5.44 IU/L). The serum levels of LH and estradiol were significantly lower in the subgroup with secondary stress-induced amenorrhoea (1.73 IU/L and 220.60 pmol/ml) compared to the subgroups with amenorrhoea due to alimentary deficiency (4.68 IU/L and 394.68 pmol/ml) or extreme physical exercise (3.74 IU/L and 323.91 pmol/ml).
In girls with secondary amenorrhea, the levels of osteocalcin were significantly lower compared to the ones in the control group (26.41 and 30.99 ng/ml) while β-CrossLaps levels were similar (0.34 and 0.98 ng/mL). High prevalence of vitamin D deficiency was observed in both the patients with secondary amenorrhoea (71.6%) and the control group (65.8%).
Significant changes in hormone levels and bone health were observed in Bulgarian adolescent girls with secondary amenorrhoea as well as high prevalence of vitamin D deficiency in both the studied and the control groups. Early diagnosis and timely interventions are needed to improve bone health in adolescents with secondary amenorrhoea.
Metacognition and self‐regulation on the road: A qualitative approach to driver attention and distraction
Authors: Love Steven , Truelove Verity , Rowland Bevan , Kannis‐Dymand Lee 
Published: October 2022

AbstractThis study aimed to explore the self‐regulatory experiences and perceptions of drivers' attentional processes on the road, via a metacognitive framework. A total of 46 Australian drivers participated in a phone interview and thematic analysis was applied to the data. The results revealed that effective self‐reported attention regulation was perceptually contingent on: driving experience, metacognitive skills used to regulate attention, and strategies to sustain attention. The perceptual difficulty of driving environments was shown to impact on self‐reported arousal, and thus the perceived ability to control and sustain attention. Similarly, cognitive confidence, and metacognitive beliefs about worry and mindless driving were shown to not only influence the tendency to engage in worry and mindless driving, but also the subjective ability to self‐regulate attention whilst doing so. This study has provided evidence for the potential of metacognitive concepts to help better understand the process of attentional lapses and difficulties on the road.
Assembly of Clay Nanotubes on Cotton Fibers Mediated by Biopolymer for Robust and High‐Performance Hemostatic Dressing
Authors: Feng Yue , He Yunqing , Lin Xiaoying , Xie Mingyang , Liu Mingxian , Lvov Yuri 
Published: October 2022

AbstractUncontrollable bleeding from military conflicts, accidents, and surgical procedures is a major life‐threatening factor. Rapid, safe, and convenient hemostasis is critical to the survival of bleeding patients in prehospital care. However, the peel‐off of hemostats such as kaolinite sheets from the cotton fibers often poses a risk of distal thrombosis. Here, an efficient clay hemostat of halloysite nanotubes is tightly bound onto commercial cotton fibers, which is capillary mediated by biopolymer alginate with Ca2+crosslinking. The robust clay nanotube dressing materials maintain high procoagulant activity after harsh water treatment, and only a few residuals of halloysite exist in the wound area. Compared with commercial hemostat QuikClot Combat gauze, halloysite‐alginate‐cotton composite dressing exhibits hemostatic properties both in vivo and in vitro with high safety. The hemostatic mechanism of the dressing is attributed to activating platelets, locally concentrating clotting components in the nanoclay, halloysite coagulation factors, and alginate cross‐linked with Ca2+. This work inspires robust self‐assembly of clay nanotubes on textile fibers and offers a hemostatic material with balanced high hemostatic activity, minimal ingredient loss, and biocompatibility. The robust dressing based on halloysite tightly bounded cotton shows great potential for military, medical, and civil bleeding control with low health risks.
Tibial torsion and pressures in the feet during walking: Implications for patterns of metatarsal robusticity
Authors: Wollmann Jessica S. , Marshall Aubree S. , Schrank McKenzie , Gruss Laura Tobias 
Published: October 2022

AbstractObjectivesThe Dmanisi Homo fossils include a tibia with a low degree of torsion and metatarsals with a pattern of robusticity differing from modern humans. It has been proposed that low tibial torsion would cause a low foot progression angle (FPA) in walking, and consequently increased force applied to the medial rays. This could explain the more robust MT III and IV from Dmanisi. Here we experimentally tested these hypothesized biomechanical relationships in living human subjects.Materials and MethodsWe measured transmalleolar axis (TMA, a proxy for tibial torsion), FPA, and plantar pressure distributions during walking in young men (n = 40). TMA was measured externally using a newly developed method. A pressure mat recorded FPA and pressure under the metatarsal heads (MT I vs. MT II–IV vs. MT V).ResultsTMA is positively correlated with FPA, but only in the right foot. Plantar pressure under MT II–IV does increase with lower TMA, as predicted, but FPA does not affect pressure. Body mass index also influenced plantar pressure distribution.DiscussionLower tibial torsion in humans is associated with slightly increased pressures along the middle rays of the foot during walking, but not because of changes in FPA. Therefore, it is possible that the low degree of torsion in the Dmanisi Homo tibia is related to the unusual pattern of robusticity in the associated metatarsals, but the mechanism behind this relationship is unclear. Future work will explore TMA, FPA, and plantar pressures during running.
Cell‐Specific Dysregulation of Iron and Oxygen Homeostasis as a Novel Pathophysiology in PSP
Authors: Lee Seojin , Martinez‐Valbuena Ivan , de Andrea Carlos E. , Villalba‐Esparza Maria , Ilaalagan Suganthini , Couto Blas , Visanji Naomi P. , Lang Anthony E. , Kovacs Gabor G. 
Published: October 2022

ObjectiveProgressive supranuclear palsy (PSP) is a 4R‐tauopathy showing heterogeneous tau cytopathology commencing in the globus pallidus (GP) and the substantia nigra (SN), regions also associated with age‐related iron accumulation. Abnormal iron levels have been extensively associated with tau pathology in neurodegenerative brains, however, its role in PSP pathogenesis remains yet unknown. We perform the first cell type‐specific evaluation of PSP iron homeostasis and the closely related oxygen homeostasis, in relation to tau pathology in human postmortem PSP brains.MethodsIn brain regions vulnerable to PSP pathology (GP, SN, and putamen), we visualized iron deposition in tau‐affected and unaffected neurons, astroglia, oligodendrocytes, and microglia, using a combination of iron staining with immunolabelling. To further explore molecular pathways underlying our observations, we examined the expression of key iron and oxygen homeostasis mRNA transcripts and proteins.ResultsWe found astrocytes as the major cell type accumulating iron in the early affected regions of PSP, highly associated with cellular tau pathology. The same regions are affected by dysregulated expression of alpha and beta hemoglobin and neuroglobin showing contrasting patterns. We discovered changes in iron and oxygen homeostasis‐related gene expression associated with aging of the brain, and identified dysregulated expression of rare neurodegeneration with brain iron accumulation (NBIA) genes associated with tau pathology to distinguish PSP from the healthy aging brain.InterpretationWe present novel aspects of PSP pathophysiology highlighting an overlap with NBIA pathways. Our findings reveal potential novel targets for therapy development and have implications beyond PSP for other iron‐associated neurodegenerative diseases. ANN NEUROL 2023;93:431–445
Effect of Mobile Stroke Unit Dispatch in all Patients with Acute Stroke or TIA
Authors: Rohmann Jessica L. , Piccininni Marco , Ebinger Martin , Wendt Matthias , Weber Joachim E. , Schwabauer Eugen , Geisler Frederik , Freitag Erik , Harmel Peter , Lorenz‐Meyer Irina , Rohrpasser‐Napierkowski Ira , Nolte Christian H. , Nabavi Darius G. , Schmehl Ingo , Ekkernkamp Axel , Endres Matthias , Audebert Heinrich J. 
Published: October 2022

ObjectiveTo determine the effect of additional mobile stroke unit (MSU) dispatch on functional outcomes among the full spectrum of stroke patients, regardless of subtype or potential contraindications to reperfusion therapies.MethodsWe used data from the nonrandomized Berlin‐based B_PROUD study (02/2017 to 05/2019), in which MSUs were dispatched based solely on availability, and the linked B‐SPATIAL stroke registry. All patients with final stroke or transient ischemic attack (TIA) diagnoses were eligible. The intervention under study was the additional dispatch of an MSU, an emergency physician‐staffed ambulance equipped to provide prehospital imaging and thrombolytic treatment, compared to conventional ambulance alone. The primary outcome was the 3‐month modified Rankin Scale (mRS) score, and the co‐primary outcome was a 3‐tiered disability scale. We identified confounders using directed acyclic graphs and obtained adjusted effect estimates using inverse probability of treatment weighting.ResultsMSUs were dispatched to 1,125 patients (mean age: 74 years, 46.5% female), while for 1,141 patients only conventional ambulances were dispatched (75 years, 49.9% female). After confounding adjustment, MSU dispatch was associated with more favorable 3‐month mRS scores (common odds ratio [cOR] = 0.82; 95% confidence interval [CI]: 0.71–0.94). No statistically significant association was found with the co‐primary outcome (cOR = 0.86; 9% CI: 0.72–1.01) or 7‐day mortality (OR = 0.94; 95% CI: 0.59–1.48).InterpretationWhen considering the entire population of stroke/TIA patients, MSU dispatch improved 3‐month functional outcomes without evidence of compromised safety. Our results are relevant for decision‐makers since stroke subtype and treatment eligibility are unknown at time of dispatch. ANN NEUROL 2023;93:50–63
Imaging of KCa3.1 Channels in Tumor Cells with PET and Small‐Molecule Fluorescent Probes
Authors: Thale Insa , Maskri Sarah , Grey Lucie , Todesca Luca Matteo , Budde Thomas , Maisuls Ivan , Strassert Cristian A. , Koch Oliver , Schwab Albrecht , Wünsch Bernhard 
Published: October 2022

AbstractThe Ca2+ activated K+ channel KCa3.1 is overexpressed in several human tumor cell lines, e. g. clear cell renal carcinoma, prostate cancer, non‐small cell lung cancer. Highly aggressive cancer cells use this ion channel for key processes of the metastatic cascade such as migration, extravasation and invasion. Therefore, small molecules, which are able to image this KCa3.1 channel in vitro and in vivo represent valuable diagnostic and prognostic tool compounds. The [18F]fluoroethyltriazolyl substituted senicapoc was used as positron emission tomography (PET) tracer and showed promising properties for imaging of KCa3.1 channels in lung adenocarcinoma cells in mice. The novel senicapoc BODIPY conjugates with two F‐atoms (9 a) and with a F‐atom and a methoxy moiety (9 b) at the B‐atom led to the characteristic punctate staining pattern resulting from labeling of single KCa3.1 channels in A549‐3R cells. This punctate pattern was completely removed by preincubation with an excess of senicapoc confirming the high specificity of KCa3.1 labeling. Due to the methoxy moiety at the B‐atom and the additional oxyethylene unit in the spacer, 9 b exhibits higher polarity, which improves solubility and handling without reduction of fluorescence quantum yield. Docking studies using a cryo‐electron microscopy (EM) structure of the KCa3.1 channel confirmed the interaction of 9 a and 9 b with a binding pocket in the channel pore.
Trends in breast cancer mortality by race/ethnicity, age, and US census region, United States─1999‐2020
Authors: Ellington Taylor D. , Henley S. Jane , Wilson Reda J. , Miller Jacqueline W. , Wu Manxia , Richardson Lisa C. 
Published: October 2022

AbstractBackgroundBreast cancer remains a leading cause of morbidity and mortality among women in the United States. Previous analyses show that breast cancer incidence increased from 1999 to 2018. The purpose of this article is to examine trends in breast cancer mortality.MethodsAnalysis of 1999 to 2020 mortality data from the Centers for Disease Control and Prevention, National Center for Health Statistics, among women by race/ethnicity, age, and US Census region.ResultsIt was found that overall breast cancer mortality is decreasing but varies by race/ethnicity, age group, and US Census region. The largest decrease in mortality was observed among non‐Hispanic White women, women aged 45 to 64 years of age, and women living in the Northeast; whereas the smallest decrease in mortality was observed among non‐Hispanic Asian or Pacific Islander women, women aged 65 years or older, and women living in the South.ConclusionThis report provides national estimates of breast cancer mortality from 1999 to 2020 by race/ethnicity, age group, and US Census region. The decline in breast cancer mortality varies by demographic group. Disparities in breast cancer mortality have remained consistent over the past two decades. Using high‐quality cancer surveillance data to estimate trends in breast cancer mortality may help health care professionals and public health prevention programs tailor screening and diagnostic interventions to address these disparities.
Rationalizing rules for immunotherapy combination trials: About time for precision immunotherapy
Authors: Desai Aakash , Subbiah Vivek 
Published: October 2022

Lay summaryImmunotherapy has changed the landscape of cancer treatment. However, the benefit of immunotherapy is seen only in some cases, with most patients experiencing cancer progression despite treatment with immunotherapy. To overcome this, combination immunotherapy treatments are being studied. Herein, we propose for a precision‐driven approach for patient selection to identify successful combinations of immunotherapy to improve outcomes for patients with cancer.
Multi‐agent architecture approach for self‐healing systems:Run‐timerecovery withcase‐basedreasoning
Authors: Rajput Pushpendra Kumar , Sikka Geeta 
Published: October 2022

SummarySelf‐healing is an approach that maintains the health of the system with proper supervision of its functioning and emerges from any unacceptable state during the execution. The complexity of modern distributed systems and dynamic hike in terms of users' access has led to an increase in maintenance. In this paper, a self‐healing architecture for services that exploit the autonomous capability of agent technology is proposed. The proposed mechanism is a multi‐agent system that comprises different agents with different capabilities and roles. The planning agent, responsible for taking the right decision to revive the system from an unhealthy state to a healthy state, uses a case‐based fault recovery mechanism at runtime. The architecture contains a persistent layer that maintains previously occurred failed cases. To determine the best suitable solution, the similarity between the detected fault and recorded failed cases is calculated. The case, having a maximum similarity index value is considered closest to the failure. Multiple recovery strategies like a replacement, restart, alternative resources are been utilized. Also, to validate the proposed architecture, an SOA‐based application is used and performance‐based evaluation metrics are analyzed.