bluuebunny/crossref_metadata_2025_split huggingface dataset:
Аксіологічно-антропологічні засади парламентаризму в Конституції Пилипа Орлика як втілення ідеї народовладдя
Authors: Ivanov S. B. 
Published: June 2022

У сучасних умовах українського державотворення та триваючих реформ державного управління актуальним залишається питання ефективного розподілу повноважень між органами влади. Вирішенню цієї проблеми сприятиме врахування історичного конституційного досвіду регламентації принципу розподілу влад, звернення до найбільш знакових документів української політичної та правової думки, дослідження питання спадкоємності вітчизняного конституційного процесу та парламентаризму. Є підстави стверджувати, що на законодавчому рівні в Україні принцип розподілу влад на законодавчу, виконавчу та судову вперше був закріплений саме у Конституції Пилипа Орлика 1710 р. У статті досліджено досвід конституювання на початку XVIII ст. парламентського органу Війська Запорізького – Генеральної Ради. Розкрито питання народного представництва у Генеральній Раді через інститут генеральних радників, повноваження «козацького парламенту» та особливості його функціонування, місце в системі державного управління.
Метою статті є аксіологічно-антропологічне обґрунтування закріплення природних прав людини в Конституції 1710 р.
Наукова новизна полягає в спробі філософсько-правового осмислення аксіологічних та антропологічних підстав народовладдя в Конституції П. Орлика за допомогою дослідження статусу законодавчого органу Війська Запорізького.
Висновки. В Конституції П. Орлика чітко відображені ідеї народовладдя, які простежуються крізь призму виборчого права, вільного волевиявлення, збереження і охорони давніх «прав та вольностей», народному представництві через інститут генеральних радників, котрі делегувалися для роботи в законодавчому органі. У документі простежуються новаторські для початку XVIII ст. ознаки парламентаризму, характерні для прогресивної правової системи, які були унормовані конституційно та мали прогресивний характер. Явище парламентаризму потребує подальшого дослідження з філософсько-правової точки зору, з позицій сучасних реалій демократичного суспільства та розвитку теорії народного представництва.
Investigation of the Possibility for Compensating the HAZ Softening of AA7075-T6
Authors: Kovács Judit , Lukács János 
Published: June 2022

New generations of high strength aluminum alloys are increasingly used in automotive industry. AA7075 is one of the strongest aluminum alloys in industrial use today. The outstanding strength properties open the possibility to use this alloy in automotive industry as a possible alternative material for car body elements instead of steels. Growing industrial demand of aluminum alloys led to the development new technologies, processes. Solution heat treatment, forming, and in-die quenching is one such technology. In our research work the different parts of the heat affected zone of AA7075-T6 high strength aluminum were examined. The thermal cycle of the heat affected zone was tested at four different temperatures (280 °C, 380 °C, 440 °C, 550 °C) with the help of physical simulation. The aim was to define the softening tendency of the heat affected zone after gas tungsten arc welding. Two heat input values 100 J/mm and 200 J/mm were selected in order to simulate a low and a high heat input welding at the given sheet thickness and welding technology by the application of Rykalin 2D model. Then the most critical subzone was selected for the further investigations. Therefore, the 380 °C temperature was examined in case of five more technical processes, which based on the solution heat treatment, forming, and in-die quenching process. The properties of the investigated subzone were examined by optical microscope and hardness test.
Optimalisasi Produksi Budidaya Benih Ikan Lele Melalui Sosialisasi Budidaya Semi-Intensif Pada Pokdakan Banturono
Authors: Musa Muhammad , Lusiana Evellin Dewi , Arsad Sulastri , Afandhi Aminudin , Lusia Dwi Ayu , Mahmudi Mohammad 
Published: June 2022

Abstrak: Malang Regency is an area that has a lot of natural resource potential, especially in the field of fisheries, both capture fisheries, and aquaculture. One of the aquaculture activities carried out by the community in Malang Regency, especially in Bantur Village is catfish aquaculture. This aquaculture activity is experiencing obstacles, namely the large proportion of operational costs for feed (> 60%) and the incompatibility of semi-intensive aquaculture practices that are applied, in which the absence of water quality monitoring has an impact on fish growth is not optimal. The purpose of this community service activity is to provide knowledge to catfish cultivators in Bantur Village about semi-intensive aquaculture systems and the manufacture of fish feed independently through training on pellet making machine technology applications. The socialization and training activities carried out have proven to be able to increase the knowledge of cultivators so that they can become their provisions to improve the quality and quantity of aquaculture products.Keywords: catfish; self-feed production; semi-intensive aquaculture; water quality;Abstract: Kabupaten Malang merupakan wilayah yang memiliki banyak potensi sumberdaya alam terutama dalam bidang perikanan baik perikanan tangkap maupun perikanan budidaya. Salah satu kegiatan perikanan budidaya yang dilakukan oleh masyarakat di kabupaten Malang, khususnya desa Bantur adalah budidaya Ikan Lele. Kegiatan budidaya ini mengalami kendala yaitu proporsi biaya operasional untuk pakan yang besar (> 60%) dan ketidaksesuaian praktik budidaya semi-intensif yang diterapkan, di mana ketiadaan pemantauan kualitas air yang ber-dampak pada pertumbuhan ikan menjadi tidak optimal. Metode dalam penelitian ini berupa konsultasi dengan Sosialisasi dan penyuluhan tentang teknologi budidaya benih Ikan Lele menggunakan sistem semi intensif, dan Pendampingan aplikasi teknologi mesin pembuat pellet untuk men-dukung budidaya benih Ikan Lele semi intensif di Pokdakan Banturo-no Tujuan kegiatan pengabdian kepada masyarakat ini adalah untuk memberikan pengetahuan kepada para pembudidaya Ikan Lele di desa Bantur mengenai sistem budidaya semi-intensif dan pembuatan pakan ikan secara mandiri melalui pelatihan aplikasi teknologi mesin pembuat pellet. Kegiatan sosialisasi dan pelatihan yang dilakukan terbukti dapat menambah pengetahuan pembudidaya, sehingga dapat menjadi bekal mereka untuk meningkatkan kualitas dan kuantitas hasil budidaya. Kata kunci: budidaya semi-intensif; ikan lele; kualitas air; pakan mandiri.
Penyuluhan Dan Pelatihan Pembuatan Sabun Cuci Piring Dari Kulit Terong Ungu Di Desa Dawuhan
Authors: Ningsih Indah Yulia , Prajitiasari Ema Desia 
Published: June 2022

Abstract: Eggplant is one of the most widely cultivated food commodities in Indonesia. One of them was carried out by "Dawuhan Jaya", the eggplant farmer group in Dawuhan Village, Tenggarang District, Bondowoso Regency, in which the majority of its members cultivated purple eggplant varieties. All the time, eggplant peel is usually thrown away when the vegetable is consumed. It only becomes unutilized waste. However, it is known that purple eggplant peel has many health benefits, including antibacterial and antioxidant. Therefore, in this service activity, product diversification of eggplant peel was carried out to process it into dish soap, a product that is widely used in households. The method used in the implementation of the activity was the participatory rural appraisal. The service activity aimed to empower the community, especially eggplant farmer group partners. The stages of activities carried out included counseling and training to increase the partner’s knowledge and skills regarding processing purple eggplant peel into high-value products. The next stage was mentoring carried out to determine and ensure the partner’s ability in production and marketing activities independently. This program was expected to be able to utilize purple eggplant by-products and increase people's income. Keywords: dish soap; product diversification; purple eggplant peel Abstrak: Terong merupakan salah satu komoditas pangan yang banyak dibudidayakan di Indonesia. Salah satunya dilakukan oleh kelompok petani terong “Dawuhan Jaya” di desa Dawuhan, kecamatan Tenggarang, kabupaten Bondowoso yang mayoritas anggotanya membudidayakan varietas terong ungu. Selama ini biasanya kulit terong selalu dibuang bila akan dikonsumsi, sehingga hanya menjadi sampah yang tak termanfaatkan. Namun, diketahui bahwa kulit terong ungu memiliki banyak manfaat bagi kesehatan, diantaranya sebagai antibakteri dan antioksidan. Oleh karena itu, dalam kegiatan pengabdian ini dilakukan upaya diversifikasi produk kulit terong menjadi produk yang banyak digunakan dalam rumah tangga, seperti sabun cuci piring. Metode yang digunakan dalam pelaksanaan kegiatan adalah participatory rural appraisal. Tahapan kegiatan yang dilakukan mencakup penyuluhan dan pelatihan untuk meningkatkan pengetahuan dan keterampilan mitra mengenai pengolahan kulit terong ungu menjadi produk yang bernilai jual tinggi. Tahapan selanjutnya adalah pendampingan yang dilaksanakan untuk mengetahui dan memastikan kemampuan mitra dalam kegiatan produksi dan pemasaran secara mandiri. Kegiatan pengabdian ini bertujuan untuk memberdayakan masyarakat, khususnya mitra kelompok petani terong. Dengan adanya kegiatan ini diharapkan dapat memanfaatkan produk sampingan terong ungu sekaligus meningkatkan pendapatan masyarakat.Kata kunci: diversifikasi produk; kulit terong ungu; sabun cuci piring
Sosialisasi Aplikasi Android M-Magazine Solusi Sarana Mading SMA Negeri 5 Padang Selama Daring
Authors: Novalia Elfina , Voutama Apriade 
Published: June 2022

Abstract: Due to the Covid-19 pandemic, the teaching-learning process for the distribution of information at SMA Negeri 5 Padang is carried out online which has an impact on the learning process and information is not optimal and impressed. Basically, schools have a source of information which is usually called Mading School during online learning, the process of disseminating information is not optimally accepted by all students. The socialization was carried out by introducing and providing training on the M-Magazine application to students and school teachers which were carried out in a hybrid/semi-offline manner as a substitute for an Android-based school wall magazine. Service activities use the Waterfall model with several stages of activities systematically or sequentially in a hybrid manner, namely Semi online/offline with a series of activities, socializing the making of the M-Magazine application, training, and implementing the M-Magazine application directly to students and teachers. As a substitute for digital school bulletin boards and can be installed on Android Gadgets for every student and teacher so that the process of disseminating information can be carried out optimally without being hindered by place and time and can be used at any time. Keywords: making school; online; m-magazine; mobile; android. Abstrak: Akibat Pandemi Covid19 proses belajar-mengajar penyaluran informasi Sekolah SMA Negeri 5 Padang dilakukan secara daring yang berdampak proses pembelajaran dan informasi tidak maksimal serta terkesan. Pada dasarnya Sekolah memiliki sumber informasi yang biasa disebut Mading Sekolah selama pembejaran daring berlangsung proses penyebaran informasi tidak maksimal diterima seluruh siswa. Sosialisasi dilakukan dengan memperkenalkan dan memberikan pelatihan tentang aplikasi M-Magazine kepada siswa dan guru Sekolah yang dilakukan secara hibrid/semi luring sebagaipengganti mading Sekolah berbasis Android. Kegiatan Pengabdian menggunakan model Waterfall dengan beberapa tahapan kegiatan secara sistematis atau berurutan secara hibrid yaitu Semi daring/luring dengan rangkaian kegiatan, sosialisasi pembuatan aplikasi M-Magazine, Pelatihan dan penerapan Aplikasi M-Magazine langsung kepada siswa dan guru. Sebagai pengganti sarana mading sekolah secara digital dan dapat diinstalkan di Gadget Android setiap Siswa dan Guru sehingga proses tersebarnya informasi dapat dilakukan secara maksimal tanpa terhalang tempat dan waktu dan dapat digunakan kapan saja.Kata kunci: mading sekolah; daring; m-magazine; mobile; android.
Memberdayakan Limbah Kantong Plastik Menjadi Nilai Yang Ekonomis Di Madrasah Ibtidaiyah Al Ikhlas Dusun Sidomulyo
Authors: Ervinawati Ervinawati , Siregar Zulkifli Musannip Efendi , Asnora Fadzil Hanafi 
Published: June 2022

Abstract: The existence of plastic waste has always been a major problem that threatens environmental sustainability. Increased plastic pollution in the soil can cause adverse effects on crops, and affect soil fertility. Plants are important for the environment and ecosystem so that plastic damages plants in the ecosystem. Community service activities carried out are in the form of training. The methods used in this training are preparing tools and materials, presentation of training materials and product manufacturing techniques, and product manufacturing processes. This plastic waste recycling activity can help create a healthy environment free from plastic waste, promote the recycling movement of plastic waste, make new materials from recycled plastic waste, use recycled materials from plastic waste, implement marketing of materials recycled materials from plastic waste, as well as realizing consumer satisfaction from the use of recycled products from plastic waste. It turns out that plastic waste which is considered useless, worthless and dangerous because it cannot decompose quickly in the environment, can provide benefits and has economic value as well as can reduce the negative impact of using plastic waste.Keywords: plastic flowers; plastic waste recycling; plastic waste. Abstrak: Keberadaan sampah plastik selalu menjadi masalah utama yang mengancam kelestarian lingkungan hidup. Meningkatnya pencemaran plastik di tanah dapat menyebabkan dampak buruk pada tanaman, dan mempengaruhi kesuburan tanah. Tumbuhan penting bagi lingkungan dan ekosistem sehingga plastik merusak tanaman di ekosistem tersebut. Kegiatan pengabdian kepada masyarakat yang dilakukan adalah berupa pelatihan. Metode yang dilakukan dalam pelatihan ini yaitu menyiapkan alat dan bahan, presentasi materi pelatihan serta teknik pembuatan produk, dan proses pembuatan produk. Kegiatan daur ulang sampah plastik tersebut dapat membantu terwujudnya lingkungan yang sehat bebas dari sampah plastik, menggalakkan gerakan daur ulang dari sampah plastik, membuat bahan-bahan baru dari daur ulang sampah plastik, menggunakan bahan-bahan daur ulang dari sampah plastik, terlaksananya pemasaran bahan-bahan daur ulang dari sampah plastik, serta mewujudkan kepuasan konsumen dari pemanfaatan produk-produk daur ulang dari sampah plastik. Ternyata sampah plastik yang dianggap tidak bermanfaat, tidak berharga dan berbahaya karena tidak dapat terurai secara cepat di lingkungan, dapat memberi manfaat dan bernilai ekonomis serta dapat mengurangi dampak negatif dari penggunaan sampah plastik. Kata kunci: bunga plastik; daur ulang sampah plastik; limbah plastik.
Paracoccidioidomicose que mimetiza câncer de adrenal: um relato de caso
Authors: Miacava Maira Lima , Santos Tauanne Fernanda dos , Galhardo Cézar Augusto Vendas 
Published: June 2022

A paracoccidioidomicose é uma patologia que apresenta imensa gama de manifestações clínicas, com etiologia fúngica e importante índice de complicações. A fisiopatologia é relacionada com a resposta imunológica de cada hospedeiro, podendo apresentar-se de forma aguda, subaguda e crônica. O quadro clínico mais relatado é relacionado a sintomas pulmonares, porém as características podem ser variáveis por tratar-se de uma infecção hematogênica. Nota-se frequente associação a trabalhadores de áreas rurais e uma considerável relação ao sexo masculino, apresenta regiões endêmicas nas quais a maior parte da população é acometida, porém com os mais variados quadros clínicos. O diagnóstico é baseado na visualização microscópica de elementos fúngicos sugestivos de Paracoccidioides spp. O tratamento está relacionado com a gravidade e os sintomas apresentados pelo individuo. O objetivo do trabalho consiste em relatar um caso de paracoccidioidomicose mimetizando câncer de adrenal.
Intervenções para reduzir erros com medicamentos potencialmente perigosos em crianças hospitalizadas: uma revisão integrativa
Authors: Araujo Denisse Santos , Garcia Andrea dos Santos , Silva Carlos Roberto Lyra da 
Published: June 2022

Erros podem ocorrer em qualquer fase da terapia medicamentosa. Os medicamentos potencialmente perigosos merecem destaque porque possuem maiores chances de danos ao paciente, em especial as crianças, por apresentarem particularidades inerentes a idade. Buscamos identificar barreiras que reduzem erros com medicamentos potencialmente perigosos em crianças hospitalizadas. Trata-se de uma revisão integrativa, cuja busca ocorreu entre Agosto e Setembro de 2020, nas bases de dados Cochrane Library, PUBMED, Google Scholar, e no meta-buscador TRIP DATABASE, para responder à questão norteadora: “Quais as intervenções na redução de erros com medicamentos potencialmente perigosos em crianças hospitalizadas?”. As buscas nas bases de dados pesquisadas capturaram 298 referências. Após as exclusões, selecionaram-se 76 estudos para serem lidos na íntegra; destes, 6 artigos foram selecionados para compor esta revisão. Foram agrupados em três categorias: Estratégias educativas; Recursos tecnológicos e; Atividades assistências. Os estudos abordam diversas estratégias para a redução de erros com medicamentos. Destaca-se aqui, a importância da associação das estratégias para o uso seguro de medicamentos potencialmente perigosos em crianças.
CRISPR/Cas9-Based Deletion of SpvB Gene From Salmonella gallinarum Leads to Loss of Virulence in Chicken
Authors: Basit Abdul , Tahir Hamza , Haider Zulquernain , Tariq Hafsa , Ullah Asim , Rehman Shafiq Ur 
Published: June 2022

Salmonella Gallinarum causes fowl typhoid in poultry leading to a huge economic loss to the poultry industry. The large virulence plasmid of S. gallinarum has been associated with various systemic infections in poultry. A five-gene spanning region (spvRABCD) of 7.8 kb on the large plasmid mainly confers virulence to the bacteria. However, the exact role of these genes in virulence has not been elucidated yet. SpvB exhibits delayed cell death by preventing actin polymerization followed by apoptosis during intracellular infection. The specific role of SpvB in causing the disease is not known yet. In the current study, the SpvB gene was deleted through CRISPR/Cas9 method from a large virulent plasmid of locally isolated S. gallinarum strain (SG18). The homology-directed repair method was used for complete deletion of SpvB gene using the modified pCas9 plasmid. The SpvB-deleted S. gallinarum strain (ΔSpvB_SG18), when tested for its virulence in broiler chicken showed no diseases signs and mortality. In addition, the avirulent strain does not affect the bird’s weight and was rapidly cleared from the liver after infection. However, it cleared from the intestine only after 4–5 days, which suggests that the ΔSpvB_SG18 strain is unable to invade from the intestine to the liver. This is the first study to report a complete gene deletion from the S. gallinarum virulent plasmid and its effect. This method will be useful for the deletion of virulent genes from S. gallinarum, to study their role in pathogenesis, and to prepare an effective vaccine strain for controlling fowl typhoid in poultry.
3D-Cultured Vascular-Like Networks Enable Validation of Vascular Disruption Properties of Drugs In Vitro
Authors: Yavvari Prabhusrinivas , Laporte Anna , Elomaa Laura , Schraufstetter Fabian , Pacharzina Inga , Daberkow Aline Dominique , Hoppensack Anke , Weinhart Marie 
Published: June 2022

Vascular-disrupting agents are an interesting class of anticancer compounds because of their combined mode of action in preventing new blood vessel formation and disruption of already existing vasculature in the immediate microenvironment of solid tumors. The validation of vascular disruption properties of these drugs in vitro is rarely addressed due to the lack of proper in vitro angiogenesis models comprising mature and long-lived vascular-like networks. We herein report an indirect coculture model of human umbilical vein endothelial cells (HUVECs) and human dermal fibroblasts (HDFs) to form three-dimensional profuse vascular-like networks. HUVECs embedded and sandwiched in the collagen scaffold were cocultured with HDFs located outside the scaffold. The indirect coculture approach with the vascular endothelial growth factor (VEGF) producing HDFs triggered the formation of progressively maturing lumenized vascular-like networks of endothelial cells within less than 7 days, which have proven to be viably maintained in culture beyond day 21. Molecular weight-dependent Texas red-dextran permeability studies indicated high vascular barrier function of the generated networks. Their longevity allowed us to study the dose-dependent response upon treatment with the three known antiangiogenic and/or vascular disrupting agents brivanib, combretastatin A4 phosphate (CA4P), and 6´-sialylgalactose (SG) via semi-quantitative brightfield and qualitative confocal laser scanning microscopic (CLSM) image analysis. Compared to the reported data on in vivo efficacy of these drugs in terms of antiangiogenic and vascular disrupting effects, we observed similar trends with our 3D model, which are not reflected in conventional in vitro angiogenesis assays. High-vascular disruption under continuous treatment of the matured vascular-like network was observed at concentrations ≥3.5 ng·ml−1 for CA4P and ≥300 nM for brivanib. In contrast, SG failed to induce any significant vascular disruption in vitro. This advanced model of a 3D vascular-like network allows for testing single and combinational antiangiogenic and vascular disrupting effects with optimized dosing and may thus bridge the gap between the in vitro and in vivo experiments in validating hits from high-throughput screening. Moreover, the physiological 3D environment mimicking in vitro assay is not only highly relevant to in vivo studies linked to cancer but also to the field of tissue regeneration.
Sustainable Production of the Cyanophycin Biopolymer in Tobacco in the Greenhouse and Field
Authors: Huckauf Jana , Brandt Boudewijn P. , Dezar Carlos , Nausch Henrik , Hauerwaas Antoniya , Weisenfeld Ursula , Elshiewy Ossama , Rua Melina , Hugenholtz Jeroen , Wesseler Justus , Cingiz Kutay , Broer Inge 
Published: June 2022

The production of biodegradable polymers as coproducts of other commercially relevant plant components can be a sustainable strategy to decrease the carbon footprint and increase the commercial value of a plant. The biodegradable polymer cyanophycin granular polypeptide (CGP) was expressed in the leaves of a commercial tobacco variety, whose seeds can serve as a source for biofuel and feed. In T0 generation in the greenhouse, up to 11% of the leaf dry weight corresponded to the CGP. In T1 generation, the maximum content decreased to approximately 4% dw, both in the greenhouse and first field trial. In the field, a maximum harvest of 4 g CGP/plant could be obtained. Independent of the CGP content, most transgenic plants exhibited a slight yield penalty in the leaf biomass, especially under stress conditions in greenhouse and field trials. After the harvest, the leaves were either Sun dried or ensiled. The resulting material was used to evaluate the extraction of CGP compared to that in the laboratory protocol. The farm-level analysis indicates that the extraction of CGP from tobacco plants can provide alternative income opportunities for tobacco farmers. The CGP yield/ha indicates that the CGP production in plants can be economically feasible depending on the cultivation and extraction costs. Moreover, we analyzed the consumer acceptance of potential applications associated with GM tobacco in four European countries (Germany, Finland, Italy and the Netherlands) and found unexpectedly high acceptance.