bluuebunny/crossref_metadata_2025_split huggingface dataset:
Augmentation of Extracellular ATP Synergizes With Chemotherapy in Triple Negative Breast Cancer
Authors: Manouchehri Jasmine M. , Datta Jharna , Willingham Natalie , Wesolowski Robert , Stover Daniel , Ganju Ramesh K. , Carson William E. , Ramaswamy Bhuvaneswari , Cherian Mathew A. 
Published: April 2022

IntroductionBreast cancer affects two million patients worldwide every year and is the most common cause of cancer-related death among women. The triple-negative breast cancer (TNBC) sub-type is associated with an especially poor prognosis because currently available therapies fail to induce long-lasting responses. Therefore, there is an urgent need to develop novel therapies that result in durable responses. One universal characteristic of the tumor microenvironment is a markedly elevated concentration of extracellular adenosine triphosphate (eATP). Chemotherapy exposure results in further increases in eATP through its release into the extracellular space of cancer cells via P2RX channels. eATP is degraded by eATPases. Given that eATP is toxic to cancer cells, we hypothesized that augmenting the release of eATP through P2RX channels and inhibiting extracellular ATPases would sensitize TNBC cells to chemotherapy.MethodsTNBC cell lines MDA-MB 231, Hs 578t and MDA-MB 468 and non-tumorigenic immortal mammary epithelial MCF-10A cells were treated with increasing concentrations the chemotherapeutic agent paclitaxel in the presence of eATPases or specific antagonists of P2RXs with cell viability and eATP content being measured. Additionally, the mRNA, protein and cell surface expressions of the purinergic receptors P2RX4 and P2RX7 were evaluated in all examined cell lines via qRT-PCR, western blot, and flow cytometry analyses, respectively.ResultsIn the present study, we observed dose-dependent declines of cell viability and increases in eATP of paclitaxel-treated TNBC cell lines in the presence of inhibitors of eATPases, but not of the MCF-10A cell line. These effects were reversed by specific antagonists of P2RXs. Similar results, as those observed with eATPase inhibitors, were seen with P2RX activators. All examined cell lines expressed both P2RX4 and P2RX7 at the mRNA, protein and cell surface levels.ConclusionThese results reveal that eATP modulates the chemotherapeutic response in TNBC cell lines, which could be exploited to enhance the efficacy of chemotherapy regimens for TNBC.
Identification of Premature Infants at High Risk of Late Respiratory Diseases: A Retrospective Cohort Study
Authors: Sun Ling , Bao Yingying , Zhang Hong , Zhu Jiajun 
Published: April 2022

AimTo identify infants with very low birth weight at risk of late respiratory diseases after discharge.MethodsThis retrospective longitudinal study included 388 preterm infants with gestational age of &lt; 32 weeks and birth weight of &lt; 1,500 g and evaluated perinatal information, assessments performed while in the neonatal intensive care unit, and longitudinal follow-up via questionnaire until the corrected gestational age of 18–24 months.ResultsThe mean birth weight and gestational age were 1,191.2 ± 191.8 g and 29.1 ± 1.4 weeks, respectively. Sixty-four (16.5%) infants developed late respiratory diseases after discharge to the corrected gestational age of 18–24 months. Univariate analyses showed that gestational age, birth weight, respiratory support, oxygen use, bronchopulmonary dysplasia diagnosed at 36 weeks’ postmenstrual age and length of hospital stay were associated with late respiratory diseases. After adjusting for covariates, respiratory support was significantly associated with serious respiratory morbidities to 18–24 months corrected gestational age. With each day of respiratory support, the odds of late respiratory diseases increased by 1.033-fold.ConclusionRespiratory support was associated with increased odds of developing late respiratory diseases during early childhood, which may be an early predictor to late respiratory morbidities. Thus, it is imperative to identify a safe and effective strategy to prevent chronic dependency on respiratory support.
Comparison of the Efficacy and Safety of a Doravirine-Based, Three-Drug Regimen in Treatment-Naïve HIV-1 Positive Adults: A Bayesian Network Meta-Analysis
Authors: Zhang Ke , Zhang Yang , Zhou Jing , Xu Lulu , Zhou Chi , Chen Guanzhi , Huang Xiaojie 
Published: April 2022

Introduction: Extensive use of antiretroviral therapy has remarkably improved the survival rates of people living with HIV. Doravirine (DOR) is a newly-approved antiretroviral belonging to the class of non-nucleoside reverse transcriptase inhibitors. Here, we compared the efficacy and safety of DOR + tenofovir dipivoxil fumarate (TDF)+Lamivudine (3TC)/Emtritabine (FTC) with traditional triple therapies in treatment-naïve HIV-1-positive adults.Methods: Randomized controlled trials involving treatment-naïve HIV-1-positive adults that met inclusion criteria were systematically retrieved and data on the following outcomes extracted: virological suppression, adverse events, severe adverse events, and drug-related adverse events. A Bayesian network meta-analysis was then performed on the data.Results: This study included a total of 39 randomized controlled trials involving 26 antiretroviral therapies and 21,110 HIV1-positive patients. At week 48, relative to the other 25 regimens included in the network of virological suppression, DOR + TDF+3TC/FTC exhibited superiority to some efavirenz, nevirapine, atazanavir, or lopinavir-based regimens, including efavirenz + abacavir+3TC [Odd Ratio (OR) = 0.52, 95% confidence interval (CrI) = 0.35–0.77]. At week 48, the performance of DOR + TDF+3TC/FTC was relatively similar to all other analyzed regimens in terms of adverse events. The DOR + TDF+3TC/FTC regimen performed better in terms of severe adverse events and drug-related adverse events.Conclusion: The network meta-analysis showed that DOR + TDF+3TC/FTC has good efficacy and safety at 48 weeks.Systematic Review Registration: Open Science Framework, https://osf.io/6ybp7.
Trends of Utilization of Antiseizure Medications Among Pregnant Women in Manitoba, Canada: A 20-Year Population-Based Study
Authors: Shouman Walid , Delaney Joseph A. , Kowalec Kaarina , Ng Marcus , Ruth Chelsea , Falk Jamieson , Leong Christine , Alessi-Severini Silvia , Lavu Alekhya , Peymani Payam , Eltonsy Sherif 
Published: April 2022

Background: Evidence from developed countries demonstrates that the use of antiseizure medications (ASMs) has been increasing in the last decade. Pregnant women have a very challenging risk benefit trade-off in terms of ASM utilization, and it is crucial to know if increased utilization is seen among pregnant women.Objective: To examine time-trends of utilization of ASM therapies among pregnant women in Manitoba, Canada.Methods: We conducted a population-based cohort study using de-identified, linked administrative databases from Manitoba. Pregnancies between 1995 and 2018 were included. Four groups of pregnant people were created based on ASM exposure and epilepsy diagnosis.Results: Of 273,492 pregnancies, 812 (3/1000) had epilepsy diagnosis and were exposed to ASMs, 963 (3.5/1000) had epilepsy diagnosis and were unexposed, and 2742 (10/1000) were exposed to ASMs and did not have epilepsy diagnosis. Overall, the number of pregnancies exposed to ASMs increased significantly from 0.56% in 1997 to 2.21% in 2018 (p &lt; 0.0001). Subgroup analysis by epilepsy diagnosis showed no significant change in ASMs exposure among pregnant women with epilepsy [the proportion of women exposed to ASM from all pregnancies was 0.37% (in 1997) and 0.36% (in 2018), p = 0.24]. A drop in carbamazepine use was observed, while the number of lamotrigine prescriptions increased from 6.45% in 1997 to 52% by 2018. ASM use among pregnant women without epilepsy increased significantly from 0.19% in 1997 to 1.85% in 2018 (p &lt; 0.0001). In the total cohort of pregnancies, 1439 (0.53%) were exposed during their entire pregnancy, and 1369 (0.5%) were exposed only in their first trimester. Clonazepam was the most used ASM during the study period (1953 users, 0.71%), followed by gabapentin (785 users, 0.29%) and carbamazepine (449 users, 0.16%).Conclusion: No major shifts in the quantity of ASM use over the study period were observed among pregnant women with epilepsy. However, there was a significant increase in ASM use among pregnant women without epilepsy. The study results warrant further investigation into the implications of ASM use in pregnancy for indications other than epilepsy.
12 Weeks of Physical Exercise Attenuates Oxidative Stress, Improves Functional Tests Performance, and Reduces Fall Risk in Elderly Women Independently on Serum 25(OH)D Concentration
Authors: Rodziewicz-Flis Ewa Aleksandra , Kawa Małgorzata , Flis Damian Józef , Szaro-Truchan Marzena , Skrobot Wojciech Romuald , Kaczor Jan Jacek 
Published: April 2022

The study aimed to evaluate if the 25(OH)D concentration is related to physical training responses. Moreover, to determine the association between serum 25(OH)D concentration and older women’s physical performance, oxidative stress markers, inflammation, and bone metabolism. 37 older women (age 72.9 ± 5.2 years) were assigned into two groups: supplemented (SG) and non-supplemented (NSG). Then, the participants from SG and NSG were randomly assigned into exercised and non-exercised groups: exercise sufficient vitamin D group (ESD; n = 10), exercise insufficient vitamin D group (EID; n = 9), control sufficient vitamin D group (CSD; n = 9), and control insufficient vitamin D group (CID; n = 9). To assess the study aims time up and go test (TUG), 6 min walk test (6MWT), fall risk test (FRT), blood osteocalcin (OC), parathormone (PTH), calcium (Ca2+), sulfhydryl groups (SH), malondialdehyde (MDA), and interleukin-6 (IL-6) were performed. The results showed that a higher 25(OH)D concentration was in line with better physical performance and bone metabolism as well as lower inflammation. After 12 weeks of training we noted an improvement in 6MWT (from 374.0 ± 17.3 to 415.0 ± 18.8; p = 0.001 and from 364.8 ± 32.8 to 419.4 ± 32.3; p = 0.001 for EID and ESD, respectively), TUG (from 7.9 ± 0.5 to 6.8 ± 0.8; p = 0.001 and from 7.3 ± 1.5 to 6.4 ± 0.9; p = 0.002, for EID and ESD, respectively), reduction of fall risk (from 2.8 ± 0.8 to 1.9 ± 0.4; p = 0.003 and from 2.1 ± 1.1 to 1.6 ± 0.5; p = 0.047, for EID and ESD, respectively) and increase in SH groups (from 0.53 ± 0.06 to 0.58 ± 0.08; p = 0.012 and from 0.54 ± 0.03 to 0.59 ± 0.04; p = 0.005, for EID and ESD, respectively), regardless of the baseline 25(OH)D concentration. A decrease in PTH and OC concentration was observed only in EID group (from 57.7 ± 15.7 to 49.4 ± 12.6; p = 0.013 for PTH and from 27.9 ± 17.2 to 18.0 ± 6.2; p = 0.004 for OC). To conclude, vitamin D concentration among older women is associated with physical performance, fall risk, inflammation, and bone metabolism markers. Moreover, 12 weeks of training improved physical performance and antioxidant protection, regardless of baseline vitamin D concentration.
Bipedal Walking of Underwater Soft Robot Based on Data-Driven Model Inspired by Octopus
Authors: Wu Qiuxuan , Wu Yan , Yang Xiaochen , Zhang Botao , Wang Jian , Chepinskiy Sergey A , Zhilenkov Anton A 
Published: April 2022

The soft organisms in nature have always been a source of inspiration for the design of soft arms and this paper draws inspiration from the octopus’s tentacle, aiming at a soft robot for moving flexibly in three-dimensional space. In the paper, combined with the characteristics of an octopus’s tentacle, a cable-driven soft arm is designed and fabricated, which can motion flexibly in three-dimensional space. Based on the TensorFlow framework, a data-driven model is established, and the data-driven model is trained using deep reinforcement learning strategy to realize posture control of a single soft arm. Finally, two trained soft arms are assembled into an octopus-inspired biped walking robot, which can go forward and turn around. Experimental analysis shows that the robot can achieve an average speed of 7.78 cm/s, and the maximum instantaneous speed can reach 12.8 cm/s.
Fungal Pathogens Associated with Crown and Root Rot of Wheat in Central, Eastern, and Southeastern Kazakhstan
Authors: Bozoğlu Tuğba , Derviş Sibel , Imren Mustafa , Amer Mohammed , Özdemir Fatih , Paulitz Timothy C. , Morgounov Alexey , Dababat Abdelfattah A. , Özer Göksel 
Published: April 2022

Kazakhstan is the fourteenth largest wheat producer in the world. Despite this fact, there has not been a comprehensive survey of wheat root and crown rot. A quantitative survey was conducted for the purpose of establishing the distribution of fungi associated with root and crown rot on wheat (Triticum spp.). During the 2019 growing season, samples were taken from the affected plants’ roots and stem bases. A total of 1221 fungal isolates were acquired from 65 sites across the central (Karagandy region), eastern (East Kazakhstan region), and southeastern (Almaty region) parts of the country and identified using morphological and molecular tools. The internal transcribed spacer (ITS), translation elongation factor 1-alpha (EF1-α), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) sequences were successfully used to identify the species of fungal isolates. It was found that Bipolaris sorokiniana (44.80%) and Fusarium acuminatum (20.39%) were the most predominant fungal species isolated, which were present in 86.15 and 66.15% of the fields surveyed, respectively, followed by F. equiseti (10.16%), Curvularia spicifera (7.62%), F. culmorum (4.75%), F. oxysporum (4.10%), F. redolens (2.38%), Rhizoctonia solani AG2-1 (1.06%), Nigrospora oryzae (0.98%), C. inaequalis (0.90%), F. pseudograminearum (0.74%), F. flocciferum (0.74%), Macrophomina phaseolina (0.66%), F. cf. incarnatum (0.33%), Fusarium sp. (0.25%), and F. torulosum (0.16%). A total of 74 isolates representing 16 species were tested via inoculation tests on the susceptible Triticum aestivum cv. Seri 82 and the results revealed that F. culmorum and F. pseudograminearum, B. sorokiniana, Fusarium sp., R. solani, F. redolens, C. spicifera, C. inaequalis, and N. oryzae were virulent, whereas others were non-pathogenic. The findings of this investigation demonstrate the presence of a diverse spectrum of pathogenic fungal species relevant to wheat crown and root rot in Kazakhstan. To the best of our knowledge, this is the first report of F. pseudograminearum, Fusarium sp., C. spicifera, and C. inaequalis as pathogens on wheat in Kazakhstan.
A Green High-Performance Thin-Layer Chromatography Method for the Determination of Caffeine in Commercial Energy Drinks and Formulations
Authors: Foudah Ahmed I. , Shakeel Faiyaz , Salkini Mohammad A. , Alshehri Sultan , Ghoneim Mohammed M. , Alam Prawez 
Published: April 2022

The literature on green analytical approaches for caffeine estimation is limited. As a consequence, this study aimed to establish a reverse-phase high-performance thin-layer chromatography (HPTLC) technique for caffeine estimation in a variety of commercial energy drinks (ED) and pharmaceutical formulations that is rapid, sensitive, and green. The combination of ethanol-water (55:45 v v−1) was used as a mobile phase. The detection of caffeine was carried out at 275 nm. The green reverse-phase HPTLC method was linear in the concentration range of 50–800 ng band−1. Furthermore, the developed method for caffeine estimation was simple, quick, economical, accurate, precise, robust, sensitive, and green. The amount of caffeine in different marketed ED (ED1–ED10) was recorded in the range of 21.02–37.52 mg 100 mL−1 using the developed HPTLC method. However, the amount of caffeine in different commercial formulations (F1–F3) was estimated as 10.63–20.30 mg 100 mL−1 using the same method. The “analytical GREEnness (AGREE)” scale for the developed analytical method was predicted to be 0.80, utilizing 12 distinct components of green analytical chemistry, indicating the HPTLC approach’s excellent greener profile. Overall, the developed method for estimating caffeine in marketed ED and dosage forms was found to be reliable.
Effect of Intrinsic Tannins on the Fermentation Quality and Associated with the Bacterial and Fungal Community of Sainfoin Silage
Authors: Huang Rongzheng , Zhang Fanfan , Wang Ting , Zhang Yulin , Li Xiao , Chen Yongcheng , Ma Chunhui 
Published: April 2022

Sainfoin (Onobrychis viciifolia) is rich in condensed tannins (CT). CT function includes inhibiting bacterial and fungi activity during the ensiling process. We used polyethylene glycol (PEG) to deactivate tannin activity to find out the effects of CT. The results show that the addition of PEG increased dry-matter loss (8.32% vs. 14.15%, on a dry-matter basis) after 60 d of ensiling, and also increased lactic acid (10.90% vs. 15.90%, on a dry-matter basis) and acetic-acid content (7.32% vs. 13.85%, on a dry-matter basis) after 30 d of ensiling. The PEG-treated group increased its Pediococcus relative abundance (0.37–3.38% vs. 7.82–23.5%,) during the ensiling process, increased its Gibellulopsis relative abundance after 3 d of ensiling (5.96% vs. 19.52%), increased its Vishniacozyma relative abundance after 3 d and 7 d of ensiling (2.36% vs. 17.02%, 3.65% vs. 17.17%), and increased its Aspergillus relative abundance after 7 d, 14 d and 60 d of ensiling (0.28% vs. 1.32%, 0.49% vs. 2.84% and 1.74% vs. 7.56%). However, the PEG-treated group decreased its Alternaria relative abundance during entire ensiling process (14.00–25.21% vs. 3.33–7.49%). These results suggest that condensed tannins inhibit lactic-acid bacteria fermentation though reducing Pediococcus activity, and inhibiting fungi activity depending on different strains.
Hydrothermal and Entropy Investigation of Nanofluid Natural Convection in a Lid-Driven Cavity Concentric with an Elliptical Cavity with a Wavy Boundary Heated from Below
Authors: Alshare Aiman , Abderrahmane Aissa , Guedri Kamel , Younis Obai , Fayz-Al-Asad Muhammed , Ali Hafiz Muhammed , Al-Kouz Wael 
Published: April 2022

This work investigates mixed convection in a lid-driven cavity. This cavity is filled with nanofluid and subjected to a magnetic field. The concentric ovoid cavity orientation (γ), 0–90°, and undulation number (N), 1–4, are considered. The Richardson number (Ri) varies between 1 and 100. The nanofluid volume fraction (φ) ranges between 0 and 0.08%. The effect of the parameters on flow, thermal transport, and entropy generation is illustrated by the stream function, isotherms, and isentropic contours. Heat transfer is augmented and the Nusselt number rises with higher Ri, γ, N, and φ. The simulations show that the heat transfer is responsible for entropy generation, while frictional and magnetic effects are marginal.
A Quantitative Study of The Most Influential Articles on Cytomegalovirus in Solid Organ Transplantation
Authors: ALKAN Sevil , GÖKÇE Oruç Numan , ŞAHİNOĞLU Mustafa Serhat 
Published: April 2022

Objectives: In this scientometric and quantitative study, the previous literature on the topic of Cytomegalovirus (CMV) in solid organ transplant (SOT) recipients was analysed. Our overarching goal was to explore the publications in this field and to identify research hotspots.
Material and Methods: The Web of Science (WoS) database was utilized to research publications. The following terms were included in the search strategy syntax: "CMV" or "CMV infection" or "Cytomegalovirus" and "solid organ" or "hepatic" or "liver" or "pancreatic" or "lung" or "heart" or "transplantation" or "organ donation". Articles were selected as the document type. The complete text data of the included publications was retrieved from the WoS database. The VOSviewer (version 1.6.10, Leiden University, Netherlands) was used to do the bibliometric study in order to display the collaboration network, emphases, and future trends in the relevant topic.
Results: 2432 results were reached from the Wos Core Collection. 1390 of them were articles. The USA was the top-ranked country (29.928%). Germany, Japan, England, and France (6.043%) were ranked in the first 5 countries. Turkey ranked 16th. 1351 (97.194%) of the publications were published in SCI-EXPANDED journals. The first article was published in the year 1971. 990 (71.87%) of the articles were published after 2000. The highest number of publications was in the year 2020 (4.892%). The H index of the articles was 100. There were a total of 45063 citations and an average of 32.42 per item. The number of citations and publications has increased over the last 30 years. The University of London was the top-ranked affiliation. Most of the articles (11.871%) were published in the journal "Transplantation Proceedings".
Conclusions: The number of publications in this field is very low, especially for developing countries. The USA, Japan, and European countries are the countries with the highest number of publications.
TINJAUAN GEOGRAFI DALAM PERILAKU ADAPTASI MASYARAKAT TERHADAP BENCANA BANJIR DI DESA MOTAAIN KECAMATAN MALAKA BARAT KABUPATEN MALAKA
Authors: Sunimbar Sunimbar , Angin Ignasius Suban 
Published: April 2022

The research objectives were to: (1) analyze the spatial distribution of the level of flood vulnerability in Motaain Village; (2) know the community's attitude towards the flood disaster in Motaain Village; and (3) know the community's adaptation strategy in dealing with flood disaster in Motaain Village.The type of research is descriptive research, which the type of research that has a purpose to explain specifically a symptom and event that is happening at the present time or an actual problem by using data in the form of quantitative and qualitative data. The study population was 196 heads of families. The sampling technique used is a random sample or random sampling or probability sampling, with a simple random sampling technique. The sample size in this study was 45 families, determined by lottery. Data sources consist of primary data and secondary data. Data collection techniques are: interviews, observation, and documentation. The data analysis technique used is qualitative and quantitative analysis.The results of the study: (1) baed on six parameters, namely soil type, elevation/place, slope, land use, rainfall and river density, the Motaain Village area has two flood-prone zones, namely a moderately vulnerable zone and a very flood-prone zone; (2) the attitude of the community before the flood disaster, during the flood disaster, and after the flood disaster varied; (3) adaptation strategies before the flood disaster, during the flood disaster, and after the flood disaster, the safety of human casualties, the economic aspect, the social aspect, the structural aspect, and the cultural aspect.
IMPLEMENTATION OF MADM SELECTION OF SQUAD E-SPORT MOBILE LEGEND MEMBERS USING MULTI-STAGE AHP
Authors: Anggraini Erika Dewi , Hadikurniawati Wiwien 
Published: April 2022

E - Sports is an electronic-based sport that provided with internet or online networks, it takes more than one person to played. Mobile Legend is an online game that is often competed in E-Sport. Many competitions makes the player of Mobile Legend want to join. In a Mobile Legend, 5 players are required to join a group to play in the game. In this case, Nyanyah Squad only looked for 3 members to join the group. Many players want to join this group make the group leader confused, so a system is needed to help determine group members. In this study using the MADM (Multi-Atribute Decission Making) multi-stage AHP (Analytic Hierarchy Process) with the criteria of skills, winrates, statistics, roles and ranks, each of which has 3 sub criteria. The AHP (Analytic Hierarchy Process) method was chosen because it uses qualitative data collected from the results based on experience and intuition, in addition to quantitative data on complex problems can be solve according to the priorities needed. The final result of this study is ranking score alternative players and the players who can join the Nyanyah Squad.
Keywords: efficiency, AHP, E - Sport members selection.