bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of O-GlcNAcylation in innate immunity and inflammation
Authors: Wang Yongqiang , Fang Xiuwu , Wang Shuai , Wang Bin , Chu Feng , Tian Zhixin , Zhang Long , Zhou Fangfang 
Published: December 2022

AbstractO-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is a highly dynamic and widespread post-translational modification (PTM) that regulates the activity, subcellular localization, and stability of target proteins. O-GlcNAcylation is a reversible PTM controlled by two cycling enzymes: O-linked N-acetylglucosamine transferase and O-GlcNAcase. Emerging evidence indicates that O-GlcNAcylation plays critical roles in innate immunity, inflammatory signaling, and cancer development. O-GlcNAcylation usually occurs on serine/threonine residues, where it interacts with other PTMs, such as phosphorylation. Thus, it likely has a broad regulatory scope. This review discusses the recent research advances regarding the regulatory roles of O-GlcNAcylation in innate immunity and inflammation. A more comprehensive understanding of O-GlcNAcylation could help to optimize therapeutic strategies regarding inflammatory diseases and cancer.
Activating transcription factor 3, glucolipid metabolism, and metabolic diseases
Authors: Hu Shuwei , Zhao Xiaojie , Li Rui , Hu Chencheng , Wu Huijuan , Li Jing , Zhang Yanqiao , Xu Yanyong 
Published: December 2022

ABSTRACTLipids and glucose exert many essential physiological functions, such as providing raw materials or energy for cellular biosynthesis, regulating cell signal transduction, and maintaining a constant body temperature. Dysregulation of lipid and glucose metabolism can lead to glucolipid metabolic disorders linked to various metabolic diseases, such as obesity, diabetes, and cardiovascular disease. Therefore, intervention in glucolipid metabolism is a key therapeutic strategy for the treatment of metabolic diseases. Activating transcription factor 3 (ATF3) is a transcription factor that acts as a hub of the cellular adaptive-response network and plays a pivotal role in the regulation of inflammation, apoptosis, DNA repair, and oncogenesis. Emerging evidence has illustrated the vital roles of ATF3 in glucolipid metabolism. ATF3 inhibits intestinal lipid absorption, enhances hepatic triglyceride hydrolysis and fatty acid oxidation, promotes macrophage reverse cholesterol transport, and attenuates the progression of western diet-induced nonalcoholic fatty liver disease and atherosclerosis. In addition to its role in lipid metabolism, ATF3 has also been identified as an important regulator of glucose metabolism. Here, we summarize the recent advances in the understanding of ATF3, mainly focusing on its role in glucose and lipid metabolism and potential therapeutic implications.
The perceived influence of COVID-19 lockdown on the circulation of counterfeit drugs and medical supplies through the electronic market
Authors: Hamdan Iman M N 
Published: December 2022

AbstractObjectivesDrugs and medical supplies counterfeiting is one of the worldwide major problems that pose a significant threat to both global public health and the economy. Nowadays, one of the major unprecedented challenges of the COVID-19 pandemic is the disastrous repercussions on the economy worldwide. The latter brought forth a noticeable rise in pharmaceutical and medical counterfeit products. Drug counterfeiting has thrived parallel to the expansion of electronic networks and the Internet during the COVID-19 pandemic. The objective of the current study is to explore the perceived influence of the COVID-19 lockdown on the circulation of counterfeit drugs and medical supplies through the electronic market in Jordan.MethodsA cross-sectional survey study was conducted in Jordan. The questionnaire was self-administered to the public as they are the probable counterfeit medicine victims and as drug counterfeiting is a nationwide problem. To capture participants’ views, a total of 460 respondents were recruited and a simple random sampling strategy was used to collect data. The inclusion criteria were consumers aged 18 years old and above, who use the Internet when purchasing drugs and medical supplies, and are willing to participate in the study.Key findingsThe study indicated an increase in using electronic websites when purchasing medicines during the COVID-19 lockdown. Additionally, there was a significant correlation the between COVID-19 lockdown and the circulation of counterfeit drugs and medical supplies through the electronic market in Jordan.ConclusionsThe study indicated that the COVID-19 lockdown had influenced counterfeit drugs and medical supplies circulation through the electronic market in Jordan.
The Impact of Mixing Survey Modes on Estimates of Change: A Quasi-Experimental Study
Authors: Cernat Alexandru , Sakshaug Joseph W 
Published: December 2022

AbstractLongitudinal surveys are a key data collection tool used to estimate social change. Recent developments have accelerated the move from traditional single-mode longitudinal designs to mixed-mode designs. Nevertheless, there are concerns that mixing survey modes may affect coefficients of change at the individual level. We investigate the impact of mixing survey modes on estimates of change using a quasi-experimental design implemented in a long-running UK panel study. Two types of comparisons are carried out: single-mode (face-to-face) design versus sequential mixed-mode (Web–face-to-face) design, and Web versus face to face. Across 41 variables, we find no differences in estimates of individual-level change across modes (designs). However, correlations between intercepts and slopes, an estimate of convergence of respondents, were significantly different for most variables, which led to some biases in estimates of change. Applied researchers are encouraged to do sensitivity checks to ensure their results are robust to mode effects.
Duration of seroprotection of the live attenuated SA-14-14-2 Japanese encephalitis vaccine in children in India
Authors: Preethi L , Alina M S , Chandran Lakshmi , Asvin S , Jagadeesan M , Vijayakumar T M , Chitra V , Pandey Ashok Kumar , Reddy Mahendra M , Misra Brij Ranjan , Kant Rajni , Bhukya Prudhvi Lal , Deshpande Gururaj Rao , Abraham Priya , Sapkal Gajanan , Zaman Kamran 
Published: December 2022

AbstractBackgroundAcute encephalitis syndrome (AES) is a major public health concern in India, and the Japanese Encephalitis (JE) virus is the most common cause of viral encephalitis in Asia affecting children under the age of 15 years. In India, despite the introduction of the JE vaccine (SA-14-14-2) in the immunization programme, JE continues to account for 15–20% of AES cases to date. This study evaluates the immunogenicity of live attenuated SA-14-14-2 JE vaccine in terms of persistence of the humoral response after two doses.MethodsA cross-sectional study was conducted among 266 children belonging to one of the JE endemic regions of Uttar Pradesh, India. Blood samples were taken from children (2–10 years) and grouped according to the duration (in years) after two doses of the vaccine (5 groups with a class interval of 2 years). Informed written consent was obtained from the parents/guardians. All the samples collected were tested for the presence of anti-JEV-specific IgG antibodies by enzyme-linked immunosorbent assay (ELISA) and further confirmed by micro neutralization test (MNT) and immunofluorescence assays.ResultsOf the 266 samples tested by ELISA for anti-JEV-specific IgG antibodies, 260 (97.74%) were negative and 6 (2.26%) were equivocal. The geometric mean immune status ratio across the five groups, 0–2 years (n = 59), 2–4 years (n = 73), 4–6 years (n = 65), 6–8 years (n = 48) and 8–10 years (n = 21) post-two doses of SA-14-14-2 JE vaccine was 1.143, 1.059, 1.138, 1.075 and 1.130, respectively, and the geometric mean titre obtained from MNT across the five groups was 10.77, 8.400, 8.453, 9.517 and 9.674, respectively.ConclusionThe study showed a decreasing trend of anti-JEV specific IgG antibody titres across the five groups based on the duration following two doses of SA-14-14-2 vaccine. The results emphasize the significance of booster doses of vaccine for children living in endemic areas.
Immunogenicity and 1-year boostability of a three-dose intramuscular rabies pre-exposure prophylaxis schedule in adults receiving immunosuppressive monotherapy: a prospective single-centre clinical trial
Authors: Garcia Garrido Hannah M , van Put Bridget , Terryn Sanne , de Pijper Cornelis A , Stijnis Cornelis , D’Haens Geert R , Spuls Phyllis I , van de Sande Marleen G , van Gucht Steven , Grobusch Martin P , Goorhuis Abraham 
Published: December 2022

AbstractBackgroundFor immunocompromised patients (ICPs), administration of rabies immunoglobulins (RIG) after exposure is still recommended regardless of prior vaccination, due to a lack of data. We aimed to assess the 1-year boostability of a three-dose rabies pre-exposure prophylaxis (PrEP) schedule in individuals using immunosuppressive monotherapy.MethodsIn this prospective study, individuals on immunosuppressive monotherapy with a conventional immunomodulator (cIM) or a TNF-alpha inhibitor (TNFi) for a chronic inflammatory disease received a three-dose intramuscular PrEP schedule (days 0,7,21–28) with 1 mL Rabipur®, followed by a two-dose simulated post-exposure prophylaxis (PEP) schedule (days 0,3) after 12 months. Rabies neutralizing antibodies were assessed at baseline, on day 21–28 (before the third PrEP dose), day 60, month 12 and month 12 + 7 days. The primary outcome was 1-year boostability, defined as the proportion of patients with a neutralizing antibody titre of ≥ 0.5 IU/mL at month 12 + 7 days. Secondary outcomes were geometric mean titres (GMTs) and factors associated with the primary endpoint.ResultsWe included 56 individuals, of whom 52 completed the study. The 1-year boostability was 90% (47/52) with a GMT of 6.16 (95% CI 3.83–9.91). All participants seroconverted at some point in the study. Early response to PrEP (at day 21–28) was significantly associated with 100% boostability (Odds Ratio 51; 95% confidence interval [5.0–6956], P &lt; 0.01). The vaccination schedule was safe and well tolerated. No vaccine-related serious adverse events occurred.ConclusionIn patients using immunosuppressive monotherapy, a three-dose rabies PrEP schedule followed by a two-dose PEP schedule is immunogenic, with all patients seroconverting at some point in the study. Although boostability 7 days after PEP was not 100%, nobody would wrongly be denied RIG when only administered to those who responded early to PrEP while reducing the administration of RIG by 73%.
Structure–function analyses of coiled-coil immune receptors define a hydrophobic module for improving plant virus resistance
Authors: Wu Xiujuan , Zhang Xuan , Wang Hongwei , Fang Rong-xiang , Ye Jian 
Published: December 2022

AbstractPlant immunity relies on nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) that detect microbial patterns released by pathogens, and activate localized cell death to prevent the spread of pathogens. Tsw is the only identified resistance (R) gene encoding an NLR, conferring resistance to tomato spotted wilt orthotospovirus (TSWV) in pepper species (Capsicum, Solanaceae). However, molecular and cellular mechanisms of Tsw-mediated resistance are still elusive. Here, we analysed the structural and cellular functional features of Tsw protein, and defined a hydrophobic module to improve NLR-mediated virus resistance. The plasma membrane associated N-terminal 137 amino acid in the coiled-coil (CC) domain of Tsw is the minimum fragment sufficient to trigger cell death in Nicotiana benthamiana plants. Transient and transgenic expression assays in plants indicated that the amino acids of the hydrophobic groove (134th–137th amino acid) in the CC domain is critical for its full function and can be modified for enhanced disease resistance. Based on the structural features of Tsw, a super-hydrophobic funnel-like mutant, TswY137W, was identified to confer higher resistance to TSWV in a SGT1 (Suppressor of G-two allele of Skp1)-dependent manner. The same point mutation in a tomato Tsw-like NLR protein also improved resistance to pathogens, suggesting a feasible way of structure-assisted improvement of NLRs.
Can bronchial secretion cultures identify the etiologic agent of COVID-19-associated pulmonary aspergillosis in ICU patients? Comparison with a species-specific Aspergillus PCR in serum
Authors: Siopi Maria , Antonopoulou Stavroula , Mantzana Paraskevi , Georgiou Panagiota-Christina , Vourli Sophia , Protonotariou Efthymia , Vagiakou Eleni , Skoura Lemonia , Pournaras Spyros , Meletiadis Joseph 
Published: December 2022

Abstract
Aspergillus spp. isolated from non-BAL cultures of coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) patients may reflect colonization rather than infection. Sera (n = 181) from 49 adult ICU CAPA patients (24 probable and 25 possible CAPA) with bronchial secretions (BS) culture positive for Aspergillus spp. were collected and tested for Aspergillus DNA detection by species-specific real-time PCR. Overall, 30/49 (61%) patients were PCR positive. BS culture/serum PCR agreement was moderate (21/30; 70%). Based on serum PCR positive patients, all CAPAs were due to A. fumigatus (80%), A. flavus (10%), and A. terreus (10%). No A. niger/A. nidulans or mixed infections were found despite positive BS cultures.
Planet engulfment signatures in twin stars
Authors: Behmard Aida , Sevilla Jason , Fuller Jim 
Published: December 2022

ABSTRACT
Planet engulfment can be inferred from enhancement of refractory elements in the photosphere of the engulfing star following accretion of rocky planetary material. Such refractory enrichments are subject to stellar interior mixing processes, namely thermohaline mixing induced by an inverse mean-molecular-weight gradient between the convective envelope and radiative core. Using mesa stellar models, we quantified the strength and duration of engulfment signatures following planet engulfment. We found that thermohaline mixing dominates during the first ∼5–45 Myr post-engulfment, weakening signatures by a factor of ∼2 before giving way to depletion via gravitational settling on longer time-scales. Solar metallicity stars in the 0.5–1.2 M⊙ mass range have observable signature time-scales of ∼1 Myr–8 Gyr, depending on the engulfing star mass and amount of material engulfed. Early type stars exhibit larger initial refractory enhancements but more rapid depletion. Solar-like stars (M = 0.9–1.1 M⊙) maintain observable signatures (&gt;0.05 dex) over time-scales of ∼20 Myr–1.7 Gyr for nominal 10 M⊕ engulfment events, with longer-lived signatures occurring for low-metallicity and/or hotter stars (1 M⊙, ∼2–3 Gyr). Engulfment events occurring well after the zero-age main sequence produce larger signals due to suppression of thermohaline mixing by gravitational settling of helium (1 M⊙, ∼1.5 Gyr). These results indicate that it may be difficult to observe engulfment signatures in solar-like stars that are several Gyr old.
A low-mass companion desert among intermediate-mass visual binaries: The scaled-up counterpart to the brown dwarf desert
Authors: Duchêne Gaspard , Oon Jner Tzern , De Rosa Robert J , Kantorski Patrick , Coy Brandon , Wang Jason J , Thomas Sandrine , Patience Jenny , Pueyo Laurent , Nielsen Eric L , Konopacky Quinn 
Published: December 2022

ABSTRACT
We present a high-contrast imaging survey of intermediate-mass (1.75–4.5 M⊙) stars to search the most extreme stellar binaries, i.e. for the lowest mass stellar companions. Using adaptive optics at the Lick and Gemini observatories, we observed 169 stars and detected 24 candidates companions, 16 of which are newly discovered, and all but three are likely or confirmed physical companions. Despite obtaining sensitivity down to the substellar limit for 75 per cent of our sample, we do not detect any companion below 0.3 M⊙, strongly suggesting that the distribution of stellar companions is truncated at a mass ratio of qmin ≳ 0.075. Combining our results with known brown dwarf companions, we identify a low-mass companion desert to intermediate-mass stars in the range 0.02 ≲ q ≲ 0.05, which quantitatively matches the known brown dwarf desert among solar-type stars. We conclude that the formation mechanism for multiple systems operates in a largely scale-invariant manner and precludes the formation of extremely uneven systems, likely because the components of a protobinary accrete most of their mass after the initial cloud fragmentation. Similarly, the mechanism to form ‘planetary’ (q ≲ 0.02) companions likely scales linearly with stellar mass, probably as a result of the correlation between the masses of stars and their protoplanetary discs. Finally, we predict the existence of a sizable population of brown dwarf companions to low-mass stars and of a rising population of planetary-mass objects towards ${\approx}1\,M_\mathrm{Jup}$ around solar-type stars. Improvements on current instrumentation will test these predictions.
A measurement of the distance to the Galactic centre using the kinematics of bar stars
Authors: Leung Henry W , Bovy Jo , Mackereth J Ted , Hunt Jason A S , Lane Richard R , Wilson John C 
Published: December 2022

ABSTRACT
The distance to the Galactic centre R0 is a fundamental parameter for understanding the Milky Way, because all observations of our Galaxy are made from our heliocentric reference point. The uncertainty in R0 limits our knowledge of many aspects of the Milky Way, including its total mass and the relative mass of its major components, and any orbital parameters of stars employed in chemo-dynamical analyses. While measurements of R0 have been improving over a century, measurements in the past few years from a variety of methods still find a wide range of R0 being somewhere within 8.0 to $8.5\, \mathrm{kpc}$. The most precise measurements to date have to assume that Sgr A* is at rest at the Galactic centre, which may not be the case. In this paper, we use maps of the kinematics of stars in the Galactic bar derived from APOGEE DR17 and Gaia EDR3 data augmented with spectrophotometric distances from the astroNN neural-network method. These maps clearly display the minimum in the rotational velocity vT and the quadrupolar signature in radial velocity vR expected for stars orbiting in a bar. From the minimum in vT, we measure $R_0 = 8.23\pm 0.12\, \mathrm{kpc}$. We validate our measurement using realistic N-body simulations of the Milky Way. We further measure the pattern speed of the bar to be $\Omega _\mathrm{bar} = 40.08\pm 1.78\, \mathrm{km\, s}^{-1}\,\mathrm{kpc}^{-1}$. Because the bar forms out of the disc, its centre is manifestly the barycentre of the bar+disc system and our measurement is therefore one of the most robust and accurate measurements of R0 to date.
A comparative analysis of the chemical compositions of Gaia-Enceladus/Sausage and Milky Way satellites using APOGEE
Authors: Fernandes Laura , Mason Andrew C , Horta Danny , Schiavon Ricardo P , Hayes Christian , Hasselquist Sten , Feuillet Diane , Beaton Rachael L , Jönsson Henrik , Kisku Shobhit , Lacerna Ivan , Lian Jianhui , Minniti Dante , Villanova Sandro 
Published: December 2022

ABSTRACT
We use data from the 17th data release of the Apache Point Observatory Galactic Evolution Experiment (APOGEE 2) to contrast the chemical composition of the recently discovered Gaia Enceladus/Sausage system (GE/S) to those of 10 Milky Way (MW) dwarf satellite galaxies: LMC, SMC, Boötes I, Carina, Draco, Fornax, Sagittarius, Sculptor, Sextans, and Ursa Minor. Our main focus is on the distributions of the stellar populations of those systems in the [Mg/Fe]–[Fe/H] and [Mg/Mn]–[Al/Fe] planes, which are commonly employed in the literature for chemical diagnosis and where dwarf galaxies can be distinguished from in situ populations. We show that, unlike MW satellites, a GE/S sample defined purely on the basis of orbital parameters falls almost entirely within the locus of ‘accreted’ stellar populations in chemical space, which is likely caused by an early quenching of star formation in GE/S. Due to a more protracted history of star formation, stars in the metal-rich end of the MW satellite populations are characterized by lower [Mg/Mn] than those of their GE/S counterparts. The chemical compositions of GE/S stars are consistent with a higher early star formation rate (SFR) than MW satellites of comparable and even higher mass, suggesting that star formation in the early universe was strongly influenced by other parameters in addition to mass. We find that the direction of the metallicity gradient in the [Mg/Mn]–[Al/Fe] plane of dwarf galaxies is an indicator of the early SFR of the system.
Rapid decline in the lightcurves of luminous supernovae by jet-driven bipolar explosions
Authors: Akashi Muhammad , Michaelis Amir , Soker Noam 
Published: December 2022

ABSTRACT
We calculate the lightcurves of jet-driven bipolar core collapse supernova (CCSN) explosions into a bipolar circumstellar matter (CSM) and show that an equatorial observer finds the lightcurves to possess a rapid, and even an abrupt drop. The scenario that might lead to such an explosive morphology is a common envelope evolution (CEE), where shortly before the CCSN explosion the red-supergiant progenitor interacts with a more compact companion that spirals-in and spins-up the core. The companion can be a main sequence star, a neutron star, or a black hole. The binary interaction ejects a shell through an intensive wind and the CEE ejects a denser gas in the equatorial plane. We assume that the companion accretes mass and launches jets. We conduct three-dimensional (3D) hydrodynamical simulations where we launch weak jets, the shaping jets, into the dense shell and show that the interaction forms a bipolar CSM. As a result of the rapid pre-collapse core rotation jets drive the CCSN explosion. We simulate the interaction of the jets with the bipolar CSM and use a simple scheme to calculate the lightcurves. We show that the abrupt drop in the lightcurve of an observer not too close to the polar directions can account for the lightcurve of the hydrogen poor luminous supernova (LSN) SN 2018don.
Polarized radio emission unveils the structure of the pre-supernova circumstellar magnetic field and the radio emission in SN1987A
Authors: Petruk O , Beshley V , Orlando S , Bocchino F , Miceli M , Nagataki S , Ono M , Loru S , Pellizzoni A , Egron E 
Published: December 2022

ABSTRACT
The detected polarized radio emission from the remnant of SN1987A opens the possibility to unveil the structure of the pre-supernova (pre-SN) magnetic field (MF) in the circumstellar medium. Properties derived from direct measurements would be of importance for understanding the progenitor stars and their MFs. As the first step to this goal, we adopted the hydrodynamic (HD) data from an elaborated three-dimensional (3D) numerical model of SN1987A. We have developed an approximate method for ‘reconstruction’ of 3D MF structure inside SN remnant on the 'HD background’. This method uses the distribution of the MF around the progenitor as the initial condition. With such a 3D magnetohydrodynamic model, we have synthesized the polarization maps for a number of SN1987A models and compared them to the observations. In this way, we have tested different initial configurations of the MF as well as a structure of the synchrotron emission in SN987A. We have recovered the observed polarization pattern and we have found that the radial component of the ambient pre-SN MF should be dominant on the length-scale of the present-day radius of SN1987A. The physical reasons for such a field are discussed.