bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategic sustainable development of Industry 4.0 through the lens of social responsibility: The role of human resource practices
Authors: Mukhuty Sumona , Upadhyay Arvind , Rothwell Holly 
Published: February 2022

AbstractResearch on sustainable development is significantly influenced by the trade‐off between the economic, social and environmental performance of businesses. Industry 4.0 development is a key business priority due to the promise of exponential increase in productivity, time efficiencies and cost reduction. However, Industry 4.0 development has been slow. Notably, human actors remain central to Industry 4.0, while the social responsibility component of sustainable development is a key prerogative for industry, championed through the UN sustainable development goals and European Commission. Therefore, we evaluate human‐related impediments for Industry 4.0 and critically explore how human resource management (HRM) can overcome these barriers using a socially responsible orientation. First, we analyse the human‐related challenges to Industry 4.0 through a thematic literature review. Thereafter, through an integrative literature review of different research streams (Industry 4.0, HRM and social responsibility), we critically argue novel perspectives on how human resource practices can enable sustainable development of Industry 4.0 in a socially responsible manner. Herein, we address a crucial literature gap. Our findings reveal numerous people‐related barriers, including change resistance, digital skills gap, employment threats widening socio‐economic inequalities, lack of industry‐wide collaboration, leadership and organisational culture challenges. We show that HRM can be a crucial enabler for sustainable Industry 4.0 development through socially responsible human resource practices. These include strategic multistakeholder collaborations, holistic talent management, change leadership, inclusive knowledge sharing, sponsoring education research and codesigning curricula, smart technology for upskilling and retention and rewarding inclusive Industry 4.0 ideas. We conclude with future research directions.
PROTOCOL: Exploring the effect of case management in homelessness per components: A systematic review of effectiveness and implementation, with meta‐analysis and thematic synthesis
Authors: Weightman Alison L. , Kelson Mark J. , Thomas Ian , Mann Mala K. , Searchfield Lydia , Hannigan Ben , Smith Robin J. , Willis Simone , Cordiner Rhiannon 
Published: February 2022

AbstractThis is the protocol for a Campbell review. The objectives are as follows: To carry out a mixed methods review to summarise current evidence relating to the components of case‐management interventions for people experiencing homelessness.
Sex‐based disparities in outcome in pediatric acute lymphoblastic leukemia: a Children’s Oncology Group report
Authors: Gupta Sumit , Teachey David T. , Chen Zhiguo , Rabin Karen R. , Dunsmore Kimberly P. , Larsen Eric C. , Maloney Kelly W. , Mattano Leonard A. , Winter Stuart S. , Carroll Andrew J. , Heerema Nyla A. , Borowitz Michael J. , Wood Brent L. , Carroll William L. , Raetz Elizabeth A. , Winick Naomi J. , Loh Mignon L. , Hunger Stephen P. , Devidas Meenakshi 
Published: February 2022

BackgroundBoys with acute lymphoblastic leukemia (ALL) have historically experienced inferior survival compared to girls. This study determined whether sex‐based disparities persist with contemporary therapy and whether patterns of treatment failure vary by sex.MethodsPatients 1 to 30.99 years old were enrolled on frontline Children’s Oncology Group trials between 2004 and 2014. Boys received an additional year of maintenance therapy. Sex‐based differences in the distribution of various prognosticators, event‐free survival (EFS) and overall survival (OS), and subcategories of relapse by site were explored.ResultsA total of 8202 (54.4% male) B‐cell ALL (B‐ALL) and 1562 (74.3% male) T‐cell ALL (T‐ALL) patients were included. There was no sex‐based difference in central nervous system (CNS) status. Boys experienced inferior 5‐year EFS and OS (EFS, 84.6% ± 0.5% vs 86.0% ± 0.6%, P = .009; OS, 91.3% ± 0.4% vs 92.5% ± 0.4%, P = .02). This was attributable to boys with B‐ALL, who experienced inferior EFS (hazard ratio [HR], 1.2; 95% confidence interval [95% CI], 1.1‐1.3; P = .004) and OS (HR, 1.2; 95% CI, 1.0‐1.4; P = .046) after adjustment for prognosticators. Inferior B‐ALL outcomes in boys were attributable to more relapses (5‐year cumulative incidence 11.2% ± 0.5% vs 9.6% ± 0.5%; P = .001), particularly involving the CNS (4.2% ± 0.3% vs 2.5% ± 0.3%; P < .0001). There was no difference in isolated bone marrow relapses (5.4% ± 0.4% vs 6.2% ± 0.4%; P = .49). There were no sex‐based differences in EFS or OS in T‐ALL.ConclusionsSex‐based disparities in ALL persist, attributable to increased CNS relapses in boys with B‐ALL. Studies of potential mechanisms are warranted. Improved strategies to identify and modify treatment for patients at highest risk of CNS relapse may have particular benefit for boys.
Clinical and Molecular Profiling to Develop a Potential Prediction Model for the Response to Alemtuzumab Therapy for Acute Kidney Transplant Rejection
Authors: Hullegie‐Peelen Daphne M. , van der Zwan Marieke , Clahsen‐van Groningen Marian C. , Mustafa Dana A.M. , Baart Sara J. , Reinders Marlies E.J. , Baan Carla C. , Hesselink Dennis A. 
Published: February 2022

Alemtuzumab, a monoclonal antibody that depletes CD52‐bearing immune cells, is an effective drug for the treatment of severe or glucocorticoid‐resistant acute kidney transplant rejection (AR). Patient‐specific predictions on treatment response are, however, urgently needed, given the severe side effects of alemtuzumab. This study developed a multidimensional prediction model with the aim of generating clinically useful prognostic scores for the response to alemtuzumab. Clinical and histological characteristics were collected retrospectively from patients who were treated with alemtuzumab for AR. In addition, targeted gene expression profiling of AR biopsy tissues was performed. Least absolute shrinkage and selection operator (LASSO) logistic regression modeling was used to construct the ALEMtuzumab for Acute Rejection (ALEMAR) prognostic score. Response to alemtuzumab was defined as patient and allograft survival and at least once an estimated glomerular filtration rate (eGFR) > 30 mL/min/1.73 m2during the first 6 months after treatment. One hundred fifteen patients were included, of which 84 (73%) had a response to alemtuzumab. The ALEMAR‐score accurately predicted the chance of response. Gene expression analysis identified 13 differentially expressed genes between responders and nonresponders. The combination of the ALEMAR‐score and selected genes resulted in improved predictions of treatment response. The present preliminary prediction model is potentially helpful for the development of stratified alemtuzumab treatment for acute kidney transplant rejection but requires validation.
Rational Guidelines for the Two‐Step Scalability of Enzymatic Polycondensation: Experimental and Computational Optimization of the Enzymatic Synthesis of Poly(glycerolazelate)
Authors: Todea Anamaria , Fortuna Sara , Ebert Cynthia , Asaro Fioretta , Tomada Stefano , Cespugli Marco , Hollan Fabio , Gardossi Lucia 
Published: February 2022

AbstractThe lipase‐catalyzed polycondensation of azelaic acid and glycerol is investigated according to a Design‐of‐Experiment approach that helps to elucidate the effect of experimental variables on monomer conversion, Mn and regioselectivity of acylation of glycerol. Chemometric analysis shows that after 24 h the reaction proceeds regardless of the presence of the enzyme. Accordingly, the biocatalyst was removed after a first step of synthesis and the chain elongation continued at 80 °C. That allowed the removal of the biocatalyst and the preservation of its activity: pre‐requites for efficient applicability at industrial scale. The experimental study, combined with docking‐based computational analysis, provides rational guidelines for the optimization of the regioselective acylation of glycerol. The process is scaled up to 73.5 g of monomer. The novelty of the present study is the rigorous control of the reaction conditions and of the integrity of the immobilized biocatalyst, which serve to avoiding any interference of free enzyme or fines released in the reaction mixture. The quantitative analysis of the effect of experimental conditions and the overcoming of some major technical bottlenecks for the scalability of enzymatic polycondensation opens new scenarios for industrial exploitation.
Examining the role of repeated test exposure over 12 months across ADNI protocols
Authors: Hammers Dustin B. , Duff Kevin , Apostolova Liana G. ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: February 2022

AbstractObjective: Changes to study protocols during longitudinal research may alter cognitive testing schedules over time. Unlike in prior Alzheimer's Disease Neuroimaging Initiative (ADNI) protocols, where testing occurred twice annually, participants enrolled in the ADNI‐3 are no longer exposed to cognitive materials at 6 months. This may affect their 12‐month performance relative to earlier ADNI cohorts, and potentially confounds data harmonization attempts between earlier and later ADNI protocols. Method: Using data from participants enrolled across multiple ADNI protocols, this study investigated whether test exposure during 6‐month cognitive evaluation influenced scores on subsequent 12‐month evaluation. Results: No interaction effects were observed between test exposure group and time at 12 months on cognitive performance. No improvements, and limited declines, were seen between baseline and 12‐month follow‐up scores on most measures. Conclusions: The 6‐month testing session had minimal impact on 12‐month performance in ADNI. Collapsing longitudinal data across ADNI protocols in future research appears appropriate.
Hidradenitis suppurativa: Topical and intralesional treatment options
Authors: Ajayi Ayodeji , Sokumbi Olayemi 
Published: February 2022

AbstractHidradenitis suppurativa (HS) is a debilitating chronic dermatologic condition characterized by inflammation of the pilosebaceous glands in skin complicated by the formation of abscesses, sinus tracts, and scarring. HS is associated with long‐term psychosocial and physical consequences. The elucidation of the pathophysiology of HS is evolving leading to the discovery of possible therapeutic options. The relapsing nature of HS and a lack of definitive curative therapy makes the need for timely treatment important to slow down disease progression. Treatment modalities vary and include local antiseptics, intralesional corticosteroids, topical antibiotics, oral antibiotics, oral retinoids, antiandrogens, biologics, and surgical interventions, among others. The purpose of this review is to discuss topical and intralesional therapies for the management of HS.
N‐terminal pro brain natriuretic peptide reference values in community‐dwelling older adults
Authors: Braisch Ulrike , Koenig Wolfgang , Rothenbacher Dietrich , Denkinger Michael , Friedrich Nele , Felix Stephan B. , Ittermann Till , Dörr Marcus , Dallmeier Dhayana 
Published: February 2022

AbstractAimsAvailable upper reference levels (URLs) in older adults for N‐terminal pro brain natriuretic peptide (NT‐proBNP), an established biomarker for heart failure, are mainly based on small samples. We aimed to identify NT‐proBNP URL in a population‐based reference sample of individuals aged ≥65 years.Methods and resultsWe analysed established NT‐proBNP predictors using quantile regression among 2459 participants of two‐independent population‐based cohorts located in Germany, the Activity and Function in the Elderly Study (ActiFE, n = 1450) and the Study of Health in Pomerania (SHIP‐TREND‐0, n = 1009). Based on predictors a reference population of 441 subjects (ActiFE, n = 227; SHIP‐TREND‐0, n = 214) without history of diabetes, cardiovascular, or pulmonary diseases and with systolic blood pressure (BP) <140 mmHg, diastolic BP ≥60 and ≤90 mmHg, haemoglobin in men ≥14 and ≤18 g/dL and in women ≥12 and ≤16 g/dL, GFR ≥60 mL/min/1.73 m2, CRP <5 mg/L, BMI ≥18 and ≤33 kg/m2, and hs‐cTnI <40 ng/L were built with NT‐proBNP median levels and 97.5% quantiles reported stratified by sex and age. In a secondary analysis the URL among 97 SHIP‐TREND‐0 participants with a left ventricular ejection fraction (LVEF) ≥50 and no diastolic dysfunction were estimated. The median age in the identified reference sample was 70 years, with 41.9% and 40.2% male participants in ActiFE and SHIP‐TREND‐0, respectively. We observed an age‐dependent increment of NT‐proBNP levels with higher values in women compared to men. Notably, NT‐proBNP levels were >125 ng/L in 165 participants (37.4%), with NT‐proBNP URL (97.5% quantiles) equal to 663, 824, 592, and 697 ng/L in men, and 343, 463, 2641, 1276 ng/L in women for ages 65–69, 70–74, 75–79, and 80+ years, respectively. In the secondary analysis with a LVEF ≥50 and no diastolic dysfunction (35 men and 62 women) NT‐proBNP levels >125 ng/L were still observed in 38 (39.2%) participants.ConclusionsThis reference sample of apparently healthy asymptomatic older adults showed an age‐related increment of NT‐proBNP levels with URL markedly higher than the European Society of Cardiology recommended cut‐off of 125 ng/L for the diagnosis of heart failure in ambulatory settings. Identifying URL in those ≥80 years remains complex. Our results attempt to provide a frame for the further investigation of age‐specific NT‐proBNP cut‐offs in older adults. Considering the demographic changes, further evaluation of NT‐proBNP URL in larger samples of older adults followed by the validation of age‐specific cut‐off values for the identification of heart failure in those 65 years or older are urgently needed.
Impact of hybrid nanofluids (Ag‐TiO2/H2O) on improving the performance of a heat exchanger with turbulent induction elements
Authors: Bisheh Mohammad Mehdi , Pourfallah Mohsen , Gholinia Mosayeb 
Published: February 2022

AbstractIn this article, the optimization of a twisted strip heat exchanger was explored aiming at enhancing heat transfer. To this end, governing equations using ANSYS‐FLUENT software and nanofluid flow using the k‐ε RNG turbulence model were simulated in the heat exchanger, respectively. The investigated parameters included temperature, pressure, velocity, turbulence kinetic energy (TKE), nanofluid concentration, nanofluid shape factor, Reynolds number, and the diameter of the spherical obstacle on the twisted tape. In addition, the applied nanoparticles were Ag and TiO2, which were combined as a hybrid with a ratio of 50%–50%. Investigations on the surface of the twisted tape with a spherical obstacle revealed a reduction in the temperature while an increase in pressure changes, velocity, and TKE. Moreover, it was specified that the application of lamina‐shaped (non‐spherical) nanofluid has the maximum convection heat transfer coefficient relative to platelets and spherical shapes. The highest heat transfer rate was achieved at a nanofluid concentration of . Based on the findings, the heat transfer rate upgraded by increasing the Reynolds number such that the highest heat transfer rate was gained at Reynolds number 18,000. Finally, the heat transfer coefficient was enhanced by approximately 52% by increasing the diameter of the obstacles from 3 to 12 mm.
Selection of the ultimate perovskite solar cell materials and fabrication processes towards its industrialization: A review
Authors: Teixeira Cristina O. , Castro Diogo , Andrade Luísa , Mendes Adélio 
Published: February 2022

AbstractHybrid organic–inorganic perovskite materials have become one of the most studied classes of light‐harvesting materials due to their exceptional properties such as high light absorption, long carrier diffusion lengths, bandgap tuning and defect tolerance. Since 2009 that the scientific community has been working on improving the power conversion efficiency (PCE) of perovskite solar cell devices, reaching now an impressive value of 25.5%. Moreover, efficiencies over 18% are often reported by several authors. Since the efficiency goal is almost fulfilled, the scientific community is currently addressing five challenges, with the ultimate objective to make this technology competitive and turn it commercial; these challenges are cost, stability, upscaling, safety and environmental impact. Given the astonishing progresses reached during the past decade and the numerous research groups working to the same goal, it is a matter of time until commercial perovskite solar devices become a reality. In this review work, the most recent achievements regarding this purpose are put together and compared, so as to suggest the most suitable perovskite solar fabrication processes and materials to produce commercial devices.
Assessment of the impact of battery selection on the feasibility of hybrid renewable energy systems
Authors: Chaurasia Ravi , Gairola Sanjay , Pal Yash 
Published: February 2022

AbstractThis paper assesses the technical, economic, and environmental feasibility of photovoltaic (PV)/wind turbines (WT)/diesel generator (DG)/battery‐based hybrid renewable energy systems (HRES) using lead acid (LA), lithium‐ion (LI), and iron Edison nickel‐iron (IE) battery technologies (BTs). The energy cost is optimized, and the obtained results are compared to select the best hybrid system. The LI battery employed in the PV/DG/battery system (206.43 kW PV, 50 kW DG, 53.04 kWh LI batteries, and 61.1 kW converter) performed comparatively much better, as levelized cost of energy (LCOE) was reduced by around 28% and 20%, and greenhouse gas (GHG) emissions were reduced by 31% and 6% as compared to the LA and IE batteries employed in HRES, respectively. In addition, sensitivity analysis reveals that the capital cost of PV and the discount rate are more critical to determining the LCOE and renewable penetration. In contrast, the effect of the battery cost and inflation rate is relatively small. Finally, comparing the optimal resource configuration has confirmed that PV/DG/LI has significantly reduced LCOE (58% less than DG/LI) and GHG emissions (87% less than DG/LI).
Potential thiosemicarbazone‐based enzyme inhibitors: Assessment of antiproliferative activity, metabolic enzyme inhibition properties, and molecular docking calculations
Authors: Yakan Hasan , Koçyiğit Ümit M. , Muğlu Halit , Ergul Mustafa , Erkan Sultan , Güzel Emre , Taslimi Parham , Gülçin İlhami 
Published: February 2022

AbstractA new series of thiosemicarbazone derivatives (1–11) were prepared from various aldehydes and isocyanates with high yields and practical methods. The structures of these compounds were elucidated by Fourier transform infrared, 1H‐nuclear magnetic resonance (NMR), 13C‐NMR spectroscopic methods and elemental analysis. Cytotoxic effects of target compounds were determined by 2,3‐bis‐(2‐methoxy‐4‐nitro‐5‐sulfophenyl)‐2H‐tetrazolium‐5‐carboxanilide assay and compound 1 showed significant cytotoxic activity against both MCF‐7 and MDA‐MB‐231 cells, with half‐maximal inhibitory concentration values of 2.97 μM and 6.57 μM, respectively. Moreover, in this study, the anticholinergic and antidiabetic potentials of these compounds were investigated. To this aim, the effect of the newly synthesized thiosemicarbazone derivatives on the activities of acetylcholinesterase (AChE) and αglycosidase (α‐Gly) was evaluated spectrophotometrically. The title compounds demonstrated high inhibitory activities compared to standard inhibitors with Ki values in the range of 122.15–333.61 nM for α‐Gly (Ki value for standard inhibitor = 75.48 nM), 1.93–12.36 nM for AChE (Ki value for standard inhibitor = 17.45 nM). Antiproliferative activity and enzyme inhibition at the molecular level were performed molecular docking studies for thiosemicarbazone derivatives. 1M17, 5FI2, and 4EY6, 4J5T target proteins with protein data bank identification with (1–11) compounds were docked for anticancer and enzyme inhibition, respectively.
Circulating inflammatory cell profiling and periodontitis: A systematic review and meta-analysis
Authors: Irwandi Rizky A , Kuswandani Sandra O , Harden Simon , Marletta Debora , D'Aiuto Francesco 
Published: February 2022

AbstractInflammation is a key driver of common noncommunicable diseases. Among common triggers of inflammation, chronic gingival inflammation (periodontitis) triggers a consistent humoral host inflammatory response, but little is known on its impact on circulating inflammatory cell profiles. We aimed to systematically appraise all the evidence linking periodontitis and its treatment to circulating inflammatory cell profiles. From 6 databases, 157 studies were eligible for qualitative synthesis and 29 studies for meta-analysis. Our meta-analysis showed that participants with periodontitis exhibited a significant mean increase in circulating CD4+, CD4+CD45RO+, IFNγ-expressing CD4+ and CD8+ T cells, CD19+CD27+ and CD5+ B cells, CD14+CD16+ monocytes, and CD16+ neutrophils but decrease in CD8+ T and CD14++CD16− monocytes. Our qualitative synthesis revealed that peripheral blood neutrophils of patients with periodontitis consistently showed elevated production of reactive oxygen species (ROS) when compared with those of healthy controls. Some evidence suggested that the treatment of periodontitis reversed the exaggerated ROS production, but limited and inconclusive data were found on several circulating inflammatory cell profiling. We conclude that periodontitis and its treatment are associated with minor but consistent alterations in circulating inflammatory cell profiles. These changes could represent key mechanisms explaining the association of periodontitis with other comorbidities such as cardiovascular disease, diabetes, and rheumatoid arthritis.
Early initiation of the respiratory syncytial virus season in 2021–2022, Greece
Authors: Pappa Styliani , Haidopoulou Katerina , Zarras Charalampos , Theodorakou Eleni , Papadimitriou Eleni , Iosifidis Elias , Gkeka Ioanna , Stoikou Konstantina , Vagdatli Eleni , Skoura Lemonia , Papa Anna 
Published: February 2022

AbstractRespiratory syncytial virus (RSV) is the most common viral pathogen causing respiratory disease in the pediatric population. An unexpected sudden upsurge of RSV infections among children was observed in September 2021 in Greece. Forty‐one rhinopharyngeal samples from children under the age of 2 years with confirmed RSV bronchiolitis were tested to identify the genotype(s) of the RSV strain(s). The children were hospitalized during September−November 2021 in three tertiary hospitals in northern Greece. A one‐step RT‐PCR which amplifies a fragment of the second hypervariable region of the G protein gene was applied. PCR products were sequenced, and phylogenetic analysis was performed. Most (80.5%) RSV cases were typed as RSV‐A, with RSV‐B accounting for 19.5% of cases. RSV‐A and RSV‐B sequences clustered within the ON1 and BA genotypes, respectively. As the same genotypes were detected in cases observed during 2016–2018 in northern Greece, it was suggested that the early upsurge of infections was not related to the emergence of novel strain(s), but it was the result of the absence of immunity among children and their mothers due to the restriction measures taken during the COVID‐19 pandemic in the previous RSV season. Awareness is needed to diagnose even the out‐of‐season RSV infections, while molecular epidemiology plays a key role in monitoring the efficacy of currently available therapeutics and for those under development.