bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Immunological Parameters by Aging in Rural Healthy Indian Adults and their Associations with Sex and Lifestyle
Authors: Agarwal Dhiraj , Paul Sourav , Lele Pallavi , Piprode Vikrant , Kawade Anand , Hajela Neerja , Bavdekar Ashish , Parulekar Varsha , Ginde Manisha , Paranjape Gandhali , Hori Tetsuji , Matsuda Kazunori , Juvekar Sanjay , Lal Girdhari 
Published: January 2022

Abstract
Several factors including sex and lifestyle have been reported to contribute to age-related alteration of immune functions. The study was undertaken to determine age-related differences in the proportion of peripheral blood mononuclear lymphocytes in the Indian population using blood samples from 67 healthy adults (33 females and 34 males) aged between 20 and 80 years old. In the linear regression analysis to estimate the relationship with age categories, there was a significant increase in the frequency of natural killer cells with aging, while their cytolytic activity significantly declined. The frequency of CD4+ T cells increased with age whereas that of CD8+ T cells decreased, resulting in age-associated increase of CD4/CD8 ratio. The subsets of B cells did not show any significant relationship with age. Although there were variations between the male and female subgroups in effect size of aging, the trends were in the same direction in all the parameters. Reduced fat intake was associated with the lower frequency of CD4+ T cells, and higher serum cotinine level was associated with higher CD4/CD8 ratio. The results indicate that cellular immunity in the Indian population is affected with aging, while the humoral immunity is less susceptible to aging.
Impact Analysis of COVID 19 Response Measures on Social Media Postings
Authors: Syed Farrukh Hasan , Sudais Muhammad 
Published: January 2022

Abstract
Declared a pandemic in March 2020, SARS-COVID19 has become a health emergency of global concern. The World Health Organization has directed the countries all over the world to take measures to stop the spread of disease. There was a public outburst for policies like lockdown and a mixed review for Working from Home on social networking platforms. By analyzing this change, we can identify the sentiment of people about different policies. A lot of work has been done on sentiment analysis of Covid19 tweets. This is an in-depth impact analysis of COVID-19 response measures on sentiments of tweets. It can help us understand the social media trends revolving around COVID19. For achieving the goal, Google Mobility Report has been used for obtaining data about the mobility in different countries. A huge collection of tweets is extracted using Twitter API. Both datasets are used to analyze multiple trends over a period of more than a year. This article shows the change in social media sentiments with the evolving state of pandemic and the steps taken by authorities. Although, number of cases have more impact on Sentiments, the impact of changing mobility of residential and non-residential areas is also not negligible because average sentiments have seen significant up and down trends because of changing government policies.
The Relationship Between Difficulty in Emotion Regulation and Alexithymia With Hostile Attribution Bias and Anger in in Adolescent Boys With High Bullying: a Path Analysis
Authors: afrashteh majid yousei , hanifeh parinaz 
Published: January 2022

Abstract
IntroductionAdolescence is one of the critical stages and the period of evolution of human physical and mental development that occurs between childhood and youth. Successful completion of this course plays a role in mental health and personality. The aim of this study was to investigate the role of Difficulty in Emotion Regulation and Alexithymia with Hostile attribution bias and Anger in adolescent boys with bullying, which plays an important role in developmental outcomes in adolescents. Methods345 male students in Zanjan, iran participated in this study.To measure self-reporting tools, Gertz and Roemer(2004) Difficulty in emotion regulation Questionnaire, Toronto Alexithymia Questionnaire(TAS-20), McBril, Milich & Handley (2003 hostile attribution bias Questionnaire, and Eiseng and Glenn Wilson (2003) Aggression Questionnaire(2009) were evaluated. Path analysis method was used to analyze the causal model. The results show a good fit of the model with the experimental data. ResultsThe results also showed a direct and significant effect between anger and Difficulty in Emotion Regulation (β =0.19, p <0.05), Alexithymia (β = 0.17, p <0.05) and Hostile attribution bias in male adolescents (β =0.32, p<0.05) with high bullying. As well the mediating role of Hostile attribution bias in the relationship between Difficulties in emotion regulation with anger is significant (β = 0.32). Moreover the mediating role of Hostile attribution bias in the relationship between Alexithymia with anger is significant (β = 0.20). ConclusionThese results contribute to the theoretical knowledge of how Alexithymia and hostile attribution bias affect anger in adolescent populations. The findings supported the mediating role of hostile attribution bias in the relationship between Difficulty in Emotion Regulation and Alexithymia with anger in adolescents. All three predictor variables are trainable and can be used in anger reduction and bullying interventions in adolescents.
Alpelisib Exhibits a Synergistic Effect with Pyrotinib and Reverses Acquired Pyrotinib Resistance in HER2+ Breast Cancer
Authors: Chen Hao , Si Yuhao , Wen Jialiang , Hu Chunlei , Xia Erjie , Wang Yinghao , Niu Jizhao , Wang Ouchen 
Published: January 2022

Abstract
Background: Human epidermal growth factor receptor 2 (HER2) plays a vital role in breast cancer progression in patients who overexpress HER2, thus promoting the rapid progress of targeted drugs development and therapy strategies advancement targeting this gene. Pyrotinib, approved in clinical by the Chinese State Drug Administration, is a novel pan-ErbB kinase inhibitor and exhibits better efficacy than lapatinib. Alpelisib is a selective PI3K p110α inhibitor approved for application in HR+, HER2-, PIK3CA mutated breast cancers. We assumed that combining pyrotinib with alpelisib worked better than single-drug treatment.Methods: We performed the drug combination assay to evaluate the combination index (CI) of pyrotinib and alpelisib in HER2+ breast cancer cell lines. Cell functional assays, RT-qPCR (Real Time-Quantitative Polymerase Chain Reaction) and western blotting were performed to elucidate the combined efficacy of two drugs and explore the underlying mechanism. Then we established the acquired pyrotinib resistant HER2+ breast cancer cell lines and evaluate the combined efficacy of two drugs in pyrotinib resistant cells and explore the potential mechanisms.Results: Our data exhibited that a combination of alpelisib and pyrotinib showed a synergistic effect in HER2+ breast cancer by enhancing cell proliferation and migration decrease, G0-G1 cell cycle arrest, and apoptosis rate increase. Additionally, alpelisib combined with pyrotinib showed a tremendous synergistic effect in acquired pyrotinib resistant cells.Conclusions: Our results provided the preclinical evidence that a combination of pyrotinib and alpelisib as an effective therapeutic strategy in treating HER2+ breast cancer, whether patients were sensitive or resistant to pyrotinib treatment.
Epidemiological Characterization of Tibial Plateau Fractures in Five Colombian Clinics
Authors: Aguilar Juan Reátiga , Rios Ximena , Edery Eduardo Gonzalez , Rosa Alfredo De La , Arzuza Laura 
Published: January 2022

Abstract
Background: Tibial plateau fractures are traumatic injuries with severities ranging from nondisplaced to complicated fractures. This study describes the epidemiological characteristics of patients with tibial plateau fractures treated in five trauma clinics.Methods: This retrospective, cross-sectional study included 1,165 patients with tibial plateau fractures treated between December 2015 and May 2017. Subjects were selected from the medical records of five institutions based on the inclusion and exclusion criteria. Age, sex, laterality, fracture type, trauma mechanism, vehicle type, classification, and associated injuries were assessed via univariate and bivariate analyses. Results: In total, 23.3% of patients with tibial fractures treated during the study period had tibial plateau fractures. Of those affected, 73% were men and 50% were younger than 40 years. Furthermore, 95.7% of fractures were caused by traffic accidents, 82.6% of which involved motorcycles. Fractures were closed in 93.1% of cases, and 78% of subjects had associated injuries. The most common fractures, according to Schatzker classification, were type VI (23%) and V (19.1%) fractures.Conclusions: Tibial plateau fractures are frequent injuries in our setting and mostly occur in men in their 30s and 40s. These fractures are typically caused by motorcycle traffic accidents. Level of Evidence: IV
Strategic low-cost energy investment opportunities and challenges towards achieving universal access (SDG7) in each African nation
Authors: Pappis Ioannis 
Published: January 2022

Abstract
Strategic energy planning to achieve universal access and cover the future energy needs in each African nation is essential to lead to effective, sustainable energy decisions to formulate mitigation and adaptation climate change policy measures. Africa can not afford a cost-increasing green energy transition pathway towards achieving SDG7. In this analysis, least-cost power generation investment options using energy systems analysis enhanced with geospatial data for each African nation are identified, considering different levels of electricity consumption per capita (Low, High) and costs of renewables (New Policies, Renewable Deployment scenarios). The power generation capacity needs to increase between 211GW (NPLs) and 302GW (RDHs) during 2021-2030 to achieve SDG7 in Africa, leading to electricity generation to rise between 6,221PJ (NPLs) - 7,527PJ (NPHs) by 2030. Higher electricity consumption levels lead to higher penetration of fossil fuel technologies in the power mix of Africa. To achieve the same electricity demand levels, decreasing renewables' costs can assist in a less carbon-intensive power system, although higher capacity is needed. However, Africa is still hard to achieve its green revolution. Depending on the scenario, grid-connected technologies are estimated to supply approximately 85%-90% of the total electricity generated in Africa in 2030, mini-grid technologies roughly 1%-6%, and stand-alone technologies 8%-11%. Solar off-grid and solar hybrid mini-grid technologies play an essential role in electrifying the current un-electrified settlements in residential areas. Natural gas will be the dominant fossil fuel source by 2030, while the decreasing costs of renewables make solar overtake hydropower. Higher penetration of renewable energy sources in the energy mix creates local jobs and increases cost-efficiency. Approximately 6.9 million (NPLs) to 9.6 million (RDHs) direct jobs can be created in Africa by expanding the power sector during 2020-2030 across the supply chain. Increasing the electricity consumption levels in Africa leads to higher total system costs, but it is estimated to create more jobs that can ensure political and societal stability. Also, the decreasing costs of renewables could further increase the penetration of renewables in the energy mix, leading to a higher number of jobs.
Synthesis, characterization of Ag-doped CdS-WO2 nanocomposite and effects of photocatalytic degradation in RhB under visible light irradiation
Authors: Roshini G. , Sathish V. , Manigandan S. , Tamilarasi A. , Priyanka E. 
Published: January 2022

Abstract
In this paper, the highly stable Ag/CdS-WO2 nanocomposite was fabricated by a facile and capping agent-free hydrothermal technique. The fabricated Ag doped CdS-WO2 nanocomposite were characterized by powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy and UV-vis diffuse reflectance (DRS) spectroscopy. The photocatalytic performance of synthesized photocatalysts was evaluated for the photodegradation of rhodamine B (Rh B) under visible light irradiation (VLI). The parameters used for the optimization of the photocatalyst were pH, catalyst dose, oxidant dose, and irradiation time. Based on this, a possible reaction mechanism for the enhancement of photocatalytic activity of Ag/CdS-WO2 has been proposed. Hence, we have a tendency to believe it might be a promising material that may be used for the photodegradation of organic pollutants present in wastewater.
A Hybrid Tuned Mass Damper for Response Mitigation of Offshore Platforms
Authors: Cao Quoc Huong 
Published: January 2022

Abstract
A new hybrid type of the Tuned Mass Damper (HTMD), which consists of a Tuned Liquid Column Damper (TLCD) fixed on the top of a traditional Tuned Mass Damper (TMD), is developed for vibration control of an offshore platform. The results obtained from the parametric investigation show that the mass ratio between TLCD and TMD significantly affects the HTMD's performance. To assess the effectiveness and robustness of HTMD, extensive comparisons are made between an optimized HTMD and an optimum TMD with the same weight as the HTMD. The numerical computations indicate that the proposed HTMD offers a higher level of effectiveness in suppressing structural vibrations compared with a traditional TMD. However, the optimum HTMD is not robust in resisting the variation of the structural stiffness.
The Impact of Background γ- Radiation on Erythrocyte Nuclear Pathology, The Serotonergic System, and Cytochrome P-450 in Hens (Gallus Gallus Domesticus) from Azerbaijan
Authors: Gaisina Aliya A. , Mekhtiev Arif A. , Nurullayeva Afag N. , Palatnikov Grigoriy M. , Shamilov Elshan N. 
Published: January 2022

Abstract
High levels of background γ-radiation exist in the suburbs of Baku, Azerbaijan. We examined the impact of radiation on erythrocyte nuclear pathologies, levels of cytochrome P-450, and serotonin-modulating anticonsolidation protein (SMAP) in the tissues of the hens from three settlements with different levels of background radiation. Higher levels of radiation resulted in increased nuclear pathologies, upregulation of tissue SMAP levels, and downregulation of cytochrome P-450.We also carried out controlled dosage studies on Wistar male rats which showed significant upregulation of heat shock proteins with molecular mass 70 kDa (HSP70) in the bone marrow 3 and 5 h later of SMAP intraperitoneal administration. Administration of SMAP to rats 3 h prior to γ-radiation exposure (8 Gy) provided significant protection to somatic cell nuclei. We conclude that SMAP can provide protection from the genotoxic effects of γ-radiation through upregulation of HSP70 or the transformation of chromatin into a condensed, more protective conformational state.
The Survivor's Suite: The Life of the International Festival of Ethnological Film in Belgrade through Interesting Times
Authors: Naumović Slobodan 
Published: January 2022

This paper is an attempt, based on many years of following the International Festival of Ethnological Film, organized by the Ethnographic Museum in Belgrade, to provide insight into the way in which it has so far fulfilled its purpose, while at the same time experiencing tumultuous, occasionally even tragic events and processes. The main question concerns the way in which “interesting times” have left their mark on and shaped the world of human experience of people who have lived through them, thus also film production and festival practice. The phrase “interesting times” is used in the sense in which it was used by the historian Eric Hobsbawm, who used it as a label for “the most extraordinary and terrible century in human history”.
Two elements are of prime importance in the paper – the assumption that “interesting times” can exist simultaneously with, and can cause or heighten emotional and creative tension, and also the fact that the limited possibilities that the resulting states of mind and initiatives can be fulfilled through the usual channels, such as political ones, can lead to attempts to satisfy them through art or cultural forms. Film production and festival activities can, under certain circumstances, offer alternative channels for expressing moods and content that arise or are enhanced during “interesting times”.
On the one hand, the framework for analysis will provide reflections on the nature and the possible social roles of film festivals, including festivals of documentary and ethnographic films. Essentially, it will be necessary to consider the questions of the types of experiences provided by the Festival to its participants and attendees, the cinematic experiences it offers, and the specific aims and ideologies advocated as part of it. On the other hand, relying on valuable testimony in the form of the Festival Catalogue, words and images which testify to the achievements of the Festival will be identified.
At the very beginning, in the turbulent times when political orders were overthrown, along with legal and ethical frameworks, it seemed that the Festival had managed to be conceptually ahead of its time. It was a dream come true and a model for many, a place where “miracles” happened. After a number of years, its long history temporarily weakened the Festival's creative potential. The times became somewhat less interesting, slightly dull even, and the Festival followed suit. And yet through all the changes, the Festival has not ceased to be a place where people meet and learn; a place where images inspire thoughts, and thoughts seek visual means of expression; a place where, by meeting Others, we learn something about ourselves as well, but also a place where by seeking to find a way to represent ourselves, we enrich Others.
The Phenomenon of University Americanization: A Critical Review by Max Weber
Authors: Jarić Isidora , Jovanović Ajzenhamer Nataša 
Published: January 2022

The paper discusses the phenomenon of Americanization of European universities in a historical perspective, referring to the critical comparison of higher education in Germany and the United States, conceived by Max Weber after the experience of his stay at American universities in 1904. In accordance with the subject and goal, the paper is divided into several thematic units that include the historical context of European university development, defining the research question, the historical and theoretical context (his trip to the International Congress of Arts and Sciences in St. Louis and defining two of Weber's key theoretical concepts (rationalization and bureaucratization) which are necessary for understanding his analysis of higher education), consideration of Weber's most important work on this topic (Wissenschaft als Beruf), and presentation of the conclusions of our analysis. The paper provides an overview of Weber's comparison of two university models: (a) the American model, which he sees as market-oriented, democratized and meritocratic, and (b) the German model, which he sees as critical, holistic and humanistic. Despite the prevailing opinion in modern Weberology that Weber was an apologist of the way in which American higher education works, in this paper we try to show that Weber in his deliberations offered a far more balanced view of the situation at universities in the two countries (United States and Germany), and that he managed to show different aspects, i.e. the advantages and disadvantages of these two, in many respects different, models of higher education and academic communities derived from them. Although the paper deals with a part of Max Weber's legacy and in that sense with a discussion that is part of the history of sociological ideas, the basic ideas that Weber argues in it have not lost their relevance in contemporary discussions on higher education reform in Europe.
Metamodernism and Language: Pandemic Era Advertising
Authors: Koprivica Lelićanin Marija , Radenković Šošić Bojana 
Published: January 2022

In cultural theory, metamodernism becomes a new cultural paradigm of the twenty-first century, epistemologically with (post) modernism, ontologically between (post) modernism, and historically beyond (post) modernism. It appears in the context of political changes following the fall of the Berlin Wall and the environment of digital progress, but also in periods of financial and ecological crises. Rather than simple “zeitgeist”, metamodernism as an arriving cultural paradigm is to be understood more as a “structure of feelings” or sentiment so pervasive that it becomes structural. Metamodernism is symbolically presented by the dual nature of God’s messenger Eros, who operates between the worlds of mortals and immortals. Another metaphor to illustrate metamodernism is a pendulum that constantly fluctuates between opposites such as modern hope and postmodern melancholy, empathy and apathy or enthusiasm and irony.
This paper examines Italian advertisements during the largest contemporary health crisis, the SARS-CoV-2 virus outbreak. The semiotic textual analysis is performed on the audio-visual commercials of well known companies, such as Vodafone and Barilla. In addition to this, several print advertisements of a local company for funeral services Taffo are considered. Different metamodern characteristics are recognised in all examined texts. In already confirmed pandemic narratives (such as “the celebration of being Italian and patriotic solidarity”, “the juxtapositioning of the “inside” and the “outside”, and the “humanization of technology at the service of human affections and emotions''), now the metamodern characteristics, as a new structure of feeling that brings hope, continuous oscillations between contrasted polls and a certain quirkiness, are being identified. The most relevant morphosyntactic, lexical and semantic traits of the Italian language in pandemic advertising are being compared with the same language tools in postmodern Italian advertising. Finally, different stylistic and pragmatic, rhetorical and semiotic tools are being interpreted and analysed, defining more closely the unique characteristics of “metamodern” pandemic advertising.