bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the implementation of sustainable development goals: does integrated reporting matter?
Authors: Hamad Salaheldin , Lai Fong Woon , Shad Muhammad Kashif , Khatib Saleh F.A. , Ali Syed Emad Azhar 
Published: December 2022

PurposeThis study aims to investigate the performance of Sustainable Development Goals (SDGs) of public listed companies (PLCs) in Malaysia through their SDGs disclosure. In addition, it examines the impact of integrated reporting (IR) quality on the SDGs’ performance.Design/methodology/approachData are collected from an initial sample of Malaysia’s top 100 market-leading PLCs from 2016 to 2020. Univariate and multivariate analyses were used to test the research hypotheses.FindingsThe results reveal an increasing trend in SDGs’ performance. Companies contributing toward the 17 SDGs grew from 14% in 2016 to 78% in 2020. On a priority basis, the average score of the five years showed that the Malaysian PLCs are paying more attention to SDG 8 Decent Work and Economic Growth (53%); SDG 12 Responsible Consumption and Production (43%); and SDG 13 Climate Action (42%). In addition, the fixed effects regression analysis proves that companies with higher IR quality are more likely to provide better SDGs disclosure.Practical implicationsThis study provides insights to policymakers, investors and management on the vital role of businesses in supporting the SDGs’ achievement and how IR reveals a turning point in achieving the United Nations SDGs’ agenda.Social implicationsThis study provides a clearer understanding of the activities seeking to achieve the SDGs and the influence of IR on them. This opens the debate for future research.Originality/valueTo the best of the authors’ knowledge, this study is a pioneer in examining whether the quality of IR influences SDGs disclosure among large companies in one of the emerging economies in Southeast Asia in its early application stage.
The impact on graduate students when a university closes
Authors: Schiff Wendy B. , Gadzichowski K. Marinka , Le Brasseur Matthew G. , Carlin Melissa C. 
Published: December 2022

Purpose
This study aimed to investigate the impact of a university’s abrupt closure on the lives of graduate students and examined the role of grit, social support and school identification as they transferred to a new institution.

Design/methodology/approach
An online survey was administered to a diverse sample of 130 psychology graduate students after their university unexpectedly closed and the students transferred to another institution to complete their degrees. The survey included both qualitative and quantitative measures of the impact on different areas of their lives, anxiety and depression, life satisfaction, social support, grit and school identification.

Findings
Students reported experiencing financial loss, family and marital strain, anger, fear, uncertainty and loss of progress toward professional goals. Nearly 40% of participants had scores indicating elevated anxiety and depression. Students with higher anxiety and depression and lower life satisfaction tended to identify less with their new institution. Both social support and grit were related to better adjustment and life satisfaction.

Originality/value
To the best of the authors’ knowledge, this is the first study to examine the impact on graduate students following the closure of an institution of higher education. The findings have implications for educational policy and graduate student support services.
A possible role for second‐hit postzygotic GJB2 mutation in porokeratotic eccrine ostial and dermal duct nevus
Authors: Chang Yi‐Han , Yang Hsing‐San , Huang Hsin‐Yu , Lee Julia Yu‐Yun , Hsu Chao‐Kai 
Published: December 2022

AbstractPorokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare type of epidermal nevus involving the eccrine acrosyringia. It typically presents as asymptomatic linear keratotic papules and plaques along the lines of Blaschko and predominantly affects the extremities. This disease has recently been linked to somatic mutations within the GJB2 locus. Only four GJB2 mutations have been previously documented for PEODDN, and the underlying genetic basis remains inconclusive. Herein, we report an 18‐year‐old female with a hyperkeratotic plaque on the dorsa of the proximal interphalangeal joint of her right ring finger, as well as multiple small hyperkeratotic papules linearly distributed on the lateral sides of her fingers occurring since birth. Histopathological results revealed prominent parakeratotic cornoid lamella‐like tiers at the opening of the eccrine secretory ducts. Whole‐exome sequencing of the affected skin tissue revealed a heterozygous germline mutation and a postzygotic somatic mutation in GJB2. In summary, this study presents a case of PEODDN with compound heterozygous mutations in GJB2, which broadens the genetic spectrum of this disease entity and implies a possible role for second‐hit mutations in the pathogenesis of PEODDN.
Human serum albumin stabilizes streptolysin S activity secreted in the extracellular milieu by streptolysin S‐producing streptococci
Authors: Yokohata Shuto , Ohkura Kazuto , Nagamune Hideaki , Tomoyasu Toshifumi , Tabata Atsushi 
Published: December 2022

AbstractAnginosus group streptococci (AGS) are opportunistic pathogens of the human oral cavity; however, their pathogenicity has not been discussed in detail. Oral streptococci live in the gingival sulcus, from where they can easily translocate into the bloodstream due to periodontal diseases and dental treatment and cause hazardous effects on the host through their virulence factors. Streptolysin S (SLS), a pathogenic factor produced by β‐hemolytic species/strains belonging to AGS, plays an important role in damaging host cells. Therefore, we investigated the SLS‐dependent cytotoxicity of β‐hemolytic Streptococcus anginosus subsp. anginosus (SAA), focusing on different growth conditions such as in the bloodstream. Consequently, SLS‐dependent hemolytic activity/cytotoxicity in the culture supernatant of β‐hemolytic SAA was stabilized by blood components, particularly human serum albumin (HSA). The present study suggests that the secreted SLS, not only from β‐hemolytic SAA, but also from other SLS‐producing streptococci, is stabilized by HSA. As HSA is the most abundant protein in human plasma, the results of this study provide new insights into the risk of SLS‐producing streptococci which can translocate into the bloodstream.
We're in This Together: The Motivational Effects of Tangible Rewards in a Group Setting*
Authors: Kachelmeier Steven J. , Williamson Michael G. , Zhang Xinyu 
Published: December 2022

ABSTRACTWe design three experiments to examine how group incentives moderate the motivational effects of cash versus tangible rewards. Our first experiment shows that, relative to individual incentives, group incentives can magnify any negative effect of the uncertain attractiveness of a less‐fungible tangible reward (versus cash), as group members must evaluate not only how attractive they find the reward themselves but also how attractive other group members are likely to find it. However, as we show in our second experiment, under group incentives, structuring a tangible reward as a shared experience among group members who like each other can mitigate any demotivating effect of an individually consumed tangible reward vis‐à‐vis a cash reward. A third experiment provides process support for our theory, showing that both the attractiveness of the reward and the degree of certainty that others will also find it attractive jointly and fully mediate our findings. As a whole, our study furthers an understanding of the multifaceted dimensions of tangible rewards, identifying incremental effects that can arise when tangible rewards are combined with group incentives.
Neuroligin‐3 in dopaminergic circuits promotes behavioural and neurobiological adaptations to chronic morphine exposure
Authors: Brandner Dieter D. , Retzlaff Cassandra L. , Kocharian Adrina , Stieve Bethany J. , Mashal Mohammed A. , Mermelstein Paul G. , Rothwell Patrick E. 
Published: December 2022

AbstractChronic opioid exposure causes structural and functional changes in brain circuits, which may contribute to opioid use disorders. Synaptic cell‐adhesion molecules are prime candidates for mediating this opioid‐evoked plasticity. Neuroligin‐3 (NL3) is an X‐linked postsynaptic adhesion protein that shapes synaptic function at multiple sites in the mesolimbic dopamine system. We therefore studied how genetic knockout of NL3 alters responses to chronic morphine in male mice. Constitutive NL3 knockout caused a persistent reduction in psychomotor sensitization after chronic morphine exposure and change in the topography of locomotor stimulation produced by morphine. This latter change was recapitulated by conditional genetic deletion of NL3 from cells expressing the Drd1 dopamine receptor, whereas reduced psychomotor sensitization was recapitulated by conditional genetic deletion from dopamine neurons. Without NL3 expression, dopamine neurons in the ventral tegmental area exhibited diminished activation following chronic morphine exposure, by measuring in vivo calcium signals with fibre photometry. This altered pattern of dopamine neuron activity may be driven by aberrant forms of opioid‐evoked synaptic plasticity in the absence of NL3: dopamine neurons lacking NL3 showed weaker synaptic inhibition at baseline, which was subsequently strengthened after chronic morphine. In total, our study highlights neurobiological adaptations in dopamine neurons of the ventral tegmental area that correspond with increased behavioural sensitivity to opioids and further suggests that NL3 expression by dopamine neurons provides a molecular substrate for opioid‐evoked adaptations in brain function and behaviour.
Effectiveness of a French mass‐media campaign in raising knowledge of both long‐term alcohol‐related harms and low‐risk drinking guidelines, and in lowering alcohol consumption
Authors: Quatremère Guillemette , Guignard Romain , Cogordan Chloé , Andler Raphaël , Gallopel‐Morvan Karine , Nguyen‐Thanh Viêt 
Published: December 2022

AbstractAimsTo evaluate the effectiveness of a French mass‐media campaign in raising knowledge of both long‐term alcohol‐related harms (LTH) and low‐risk drinking guidelines (LRDG), as well as in lowering alcohol consumption.DesignAn 8‐month longitudinal survey from February to October 2019, with three waves of on‐line data collection (T0 before the campaign, T1 just after it ended and T2 6 months after it ended).SettingFrance.ParticipantsA total of 2538 adult drinkers (aged 18–75 years).MeasurementsThe main outcomes’ variables were LTH knowledge (cancer, hypertension, brain haemorrhage), LRDG knowledge (two guidelines: ‘maximum of two drinks a day’ and ‘minimum of 2 days without alcohol per week’), intention to reduce alcohol consumption and self‐declared consumption with respect to the French LRDG. At T1, exposure to the campaign was measured using self‐reported campaign recall.FindingsIn T1, we observed significant positive interactions between exposure group based on campaign recall and survey waves on knowledge of (i) the ‘maximum two drinks a day’ guideline [adjusted odds ratio (aOR) = 1.32, 95% confidence interval (CI) = 1.08–1.62, P = 0.008], (ii) brain haemorrhage (aOR = 1.80, 95% CI = 1.44–2.25, P < 0.001) and (iii) hypertension (aOR = 1.41, 95% CI = 1.09–1.81, P = 0.008) risks. Campaign exposure was also associated with a significant decrease in at‐risk drinking in women (aOR = 0.67, 95% CI = 0.50–0.88, P = 0.004). No significant interaction was observed at T1 for the knowledge of the ‘minimum of 2 days without alcohol a week’ guideline, or of cancer risk. At T2, no significant interaction was observed for the main outcomes’ variables.ConclusionsThere appears to be an association between exposure to a 2019 French mass‐media campaign to raise knowledge of long‐term alcohol‐related harms and low‐risk drinking guidelines and reduce alcohol consumption and (i) improved knowledge of the ‘maximum two drinks per day guideline’, (ii) knowledge of the risks of hypertension and brain haemorrhage and (iii) a reduction in the proportion of people exceeding low‐risk drinking guidelines (in the general population only). These associations were only observed over the short term and, in some cases, only for certain segments of the population.
Diagnosis of immediate reactions to amoxicillin: Comparison of basophil activation markers CD63 and CD203c in a prospective study
Authors: Céspedes Jose A. , Fernández‐Santamaría Rubén , Ariza Adriana , Bogas Gador , Doña Inmaculada , Rondón Carmen , Salas María , Labella Marina , Frecha Cecilia , Mayorga Cristobalina , Torres María J. , Fernández Tahia D. 
Published: December 2022

AbstractBackgroundAmoxicillin (AX) combined or not with clavulanic acid (CLV) is frequently involved in IgE‐mediated reactions. Drug provocation test (DPT) is considered as the gold standard for diagnosis, although contraindicated in high‐risk patients. Basophil activation test (BAT) can help diagnose immediate reactions to beta‐lactams, although controversy exists regarding the best activation marker. We have performed a real‐life study in a prospective cohort to analyze the real value of BAT as diagnostic tool and the best activation marker, CD63 and CD203c, for the evaluation of immediate reactions to these drugs.MethodsWe prospectively evaluated patients with a clinical suspicion of immediate reactions after AX or AX‐CLV administration during a 6‐year period. The allergological work‐up was done following the EAACI recommendations. BAT was performed in all patients using CD63 and CD203c as activation markers.ResultsIn AX‐allergic patients, both activation markers, CD63 and CD203c, showed similar SE values (48.6% and 46.7%, respectively); however, specificity was of 81.1% and 94.6%, respectively, with CD203c showing good positive predictive value and like‐hood ratio. In CLV‐allergic patients, CD203c showed higher SE (50%) than CD63 (42.9%), maintaining the same value of SP (80%). Combining the results of both markers can slightly increase the sensitivity (51.4% for AX and 54.8% for CLV), although decreasing the specificity (79.7% and 73%, respectively). Interestingly, all patients with an anaphylactic shock showed a positive BAT to CLV using CD203c.ConclusionsBAT using CD203c showed a good confirmatory power, especially for AX allergy. Placing BAT as a first step in the diagnostic procedure can help reduce the need of performing a complete allergological work‐up in 46.6% of patients, diminishing the risk of reinducing allergic reactions.
A case of congenital left ventricular diverticulum in an adult patient
Authors: Li Zhen‐Zhen , Zhang Wen‐Long , Zhu Mei , Liang Hao 
Published: December 2022

AbstractCongenital left ventricular diverticulum (CL.koVD) refers to a localized cystic protrusion of the ventricular wall that interacts with the heart cavities through a narrow channel and is a rare heart malformation. In recent years, many cases of this disease involving infants and children have been reported, while few cases involving adults have been described. The case of an adult with CLVD who underwent successful surgery was retrospectively evaluated. The echocardiography examination indicated that the apical myocardium of the left ventricle was thin and bulging outward and that the contractile movement was significantly reduced. During the surgery, it was observed that the left ventricle was enlarged, and a left ventricular diverticulum structure was observed on the left side of the apex. A bovine pericardial patch of the corresponding size was used to continuously suture and repair the internal orifice of the diverticulum. The postoperative pathology revealed that the resected sample was composed of full myocardial tissue. This report focused on the imaging characteristics of left ventricular diverticula to improve the understanding of CLVD. With its simple, economical, and noninvasive characteristics, echocardiography presents the best option for diagnosing a ventricular diverticulum.
Sodium butyrate administration modulates the ruminal villus height, inflammation‐related gene expression, and plasma hormones concentration in dry cows fed a high‐fiber diet
Authors: Fukumori Rika , Doi Kazuya , Mochizuki Taisei , Oikawa Shin , Gondaira Satoshi , Iwasaki Tomohito , Izumi Kenichi 
Published: December 2022

AbstractThe objectives of this study were to evaluate the effects of sodium butyrate on the ruminal villus morphology, mRNA expression associated with nutrient metabolism and inflammation in the ruminal epithelium, and plasma concentrations of metabolites and hormones in non‐lactating cows fed a high‐fiber diet. Four Holstein cows with a rumen cannula were assigned to two treatments in a crossover design. The treatments were ruminal administration of sodium butyrate premix or control premix before feeding to cows fed the same total mixed ration mainly composed of glass silage once a day. Sodium butyrate was provided at a butyrate dose of 0.04% per kg body weight. The control premix was made by replacing sodium‐butyrate with wheat bran. The plasma β‐hydroxybutyrate concentration increased 3 to 6 h after the butyrate premix administration but returned to a concentration similar to that of the control before feeding. After continuous administration, increases in the ruminal villus height and plasma concentration of glucagon‐like peptide‐2, and lower gene expression of TNF‐α, IL‐1β, and TLR‐2 in the rumen epithelium were observed in cows supplied with the butyrate premix. These results showed that sodium butyrate affects rumen epithelial morphology and plasma concentrations of hormones even under a low fermentable diet.
The generational impact of household clutter
Authors: Nix Caitlyn A. , Dozier Mary E. 
Published: December 2022

AbstractObjectivesHoarding disorder can create long‐term problems for adult children of individuals with hoarding symptoms; however, the extent of the psychosocial consequences of growing up in a cluttered household are not yet fully understood. This study investigated the extent to which generational clutter (i.e., parent/caregiver and grandparent) influenced individuals' self‐reported hoarding severity and psychiatric and psychosocial functioning.MethodsA total of 1306 adults completed an online survey that included measures of hoarding, anxiety, depression, companionship and emotional support. A subsample (n = 198) reported on parent and grandparent household clutter, as well as family impact from hoarding. We used correlations, t‐tests, linear and hierarchical regressions and mediation analyses to investigate whether hoarding symptoms were predicted by parent or grandparent hoarding.ResultsParent clutter level significantly predicted participant hoarding symptoms. For participants who reported having caregivers with elevated clutter, self‐reported psychosocial functioning was lower overall. Self‐reported behaviour modification due to family hoarding symptoms (accommodation) was a significant predictor of participant hoarding symptoms.ConclusionsParent clutter and family accommodation behaviours may be a risk factor for future clutter in adult children. Further comparisons between parents and children are needed to determine whether this association increases children's risk for future hoarding symptoms.
Safety, tolerability, pharmacodynamics and pharmacokinetics following once‐daily doses of BI 187004, an inhibitor of 11 beta‐hydroxysteroid dehydrogenase‐1, over 28 days in patients with type 2 diabetes mellitus and overweight or obesity
Authors: Bianzano Susanna , Nordaby Matias , Plum‐Mörschel Leona , Peil Barbara , Heise Tim 
Published: December 2022

AbstractAimsTo study the oral 11 beta‐hydroxysteroid dehydrogenase‐1 (11β‐HSD1) inhibitor BI 187004 (NCT02150824), as monotherapy and in combination with metformin, versus placebo in patients with type 2 diabetes mellitus (T2DM) affected by overweight or obesity.Materials and MethodsThis Phase II, randomized controlled trial investigated multiple rising doses of BI 187004 as monotherapy (Arm 1: 20, 80 or 240 mg) and in combination with metformin (Arm 2: 240 mg), in adults with T2DM and a body mass index of 28–40 kg/m2.ResultsIn total, 103 patients (Arm 1: n = 62, Arm 2: n = 41) were included in this study. BI 187004 was rapidly absorbed and exposure increased approximately dose‐dependently. Target engagement of 11β‐HSD1 was observed with near‐full inhibition of 11β‐HSD1 in the liver [decreased (5α‐tetrahydrocortisol + 5β‐tetrahydrocortisol)/tetrahydrocortisone ratio]; hypothalamic–pituitary–adrenal axis activation was also seen (increased total urinary corticosteroids). No clinically relevant changes from baseline with BI 187004 treatment were observed for bodyweight or meal tolerance test parameters, or in most efficacy endpoints testing glucose and lipid metabolism; a significant increase was observed in weighted mean plasma glucose (p < .05 for 80 and 240 mg BI 187004) but not fasting plasma glucose. Drug‐related adverse events were reported for 14 patients (22.6%) in Arm 1 and 10 patients (24.4%) in Arm 2, most frequently headache, diarrhoea, flushing and dizziness. A dose‐dependent increase in heart rate was seen with BI 187004 treatment.ConclusionsBI 187004 was generally well tolerated in patients with T2DM. Despite complete 11β‐HSD1 inhibition, no clinically relevant effects were observed with BI 187004.
Monocytosis in primary care and risk of haematological malignancies
Authors: Christensen Mathilde Egelund , Siersma Volkert , Kriegbaum Margit , Lind Bent Struer , Samuelsson Jan , Østgård Lene Sofie Granfeldt , Grønbæk Kirsten , Andersen Christen Lykkegaard 
Published: December 2022

AbstractMonocytosis (≥0.5 × 109/L in peripheral blood) is the hallmark of chronic myelomonocytic leukaemia (CMML) but may be present in a spectrum of diseases including other haematological malignancies. In the primary care sector, monocytosis is a relatively common finding, but its predictive value for haematological malignancy is unknown. We included 663 184 adult primary care patients from the greater Copenhagen area with one or more differential cell counts registered between 2000 and 2016 and followed them in the extensive nationwide Danish health data registers for 3 years after blood sampling. We used logistic regression to model the risk of haematological malignancy and death following monocytosis. Monocytosis was associated with an increased risk of all types of haematological malignancy with the greatest relative risk increase observed in CMML with an OR of 105.22 (95% confidence interval: 38.27–289.30). Sustained monocytosis (at least two requisitions in 3 months) further increased CMML risk, although the diagnosis was still very rare, that is, observed in only 0.1% of these individuals. Outside the haematological setting, the absolute risk of haematological malignancy associated with monocytosis is low and haematological malignancy should mainly be suspected when monocytosis is sustained or the clinical presentation raises suspicion of malignancy.