bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teaching and learning in interprofessional ethics education: Tutors’ perspectives
Authors: Ko Hsun-Kuei , Lin Yu-Chih , Wang Shin-Yun , Hsu Min-Tao , Yordy Morgan , Tsai Pao-Feng , Lin Hui-Ju 
Published: October 2022

Background Ethical dilemmas that arise in the clinical setting often require the collaboration of multiple disciplines to be resolved. However, medical and nursing curricula do not prioritize communication among disciplines regarding this issue. A common teaching strategy, problem-based learning, could be used to enhance communication among disciplines. Therefore, a university in southern Taiwan developed an interprofessional ethics education program based on problem-based learning strategies. This study described tutors’ experience teaching in this program. Aim To explore the phenomenon of teaching and learning in interprofessional ethics education for medical and nursing students from the perspectives of tutors. Design Phenomenological qualitative research. Methods Medical and nursing students completed a 6-week interprofessional ethics education program moderated by either physician or nurse tutors. At the conclusion of the ethics education program, all 14 tutors were invited to participate in focus group interviews. Among them, six tutors (three nursing tutors and three physician tutors) participated in additional individual interviews. All of the contents from the focus group interviews and individual interviews were recorded and transcribed. Using the phenomenological approach, the phenomenon of teaching and learning in interprofessional ethics education were generated. Ethical consideration The study was approved by the Institutional Review Board. Findings Three themes emerged from the tutors' teaching perspectives, including the instructor’s motivation to teach, the use of narrative case scenarios, and the emphasis on improving interprofessional ethics communication. Discussion Problem-based learning creates an interprofessional communication platform in interprofessional ethics education. The phenomenon of value convergence between tutors and students, between different students’ professions, and between different students’ professional maturities is observed. Conclusion Problem-based learning is an effective teaching strategy for creating a communication platform for interprofessional ethics education. Ethic curriculum should emphasize motivating instructor, use narrative case scenarios, and focus on interprofessional communication.
Pilot Study on the Impact of a Home-Based Exercise Program on Inflammatory Cytokines and Quality of Life in Men with Prostate Cancer Under Active Surveillance
Authors: Moon Crisann , Gallegos Amber M. , Sheikh Bilal , Kumar Pratap , Liss Michael , Patel Darpan I. 
Published: October 2022

Objectives This study aimed to demonstrate potential translation of pre-clinical studies to a home-based exercise intervention in mediating inflammatory cytokine markers and tumor progression in men under active surveillance for prostate cancer. Methods A 2-arm randomized control parallel group design was used. The exercise intervention consisted of 24 weeks of an aerobic and resistance home-based exercise program and results were compared to a waitlist control group. Data were collected at baseline and end of study for eotaxin, interferon-γ (INF-γ), interleukin-12 (IL-12), interleukin-1α (IL-1α), interleukin-5 (IL-5), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and vascular endothelial growth factor (VEGF), distanced walked during a 6-minute walk test (6MWT), body mass index, and health-related quality of life. Results Non-significant decreases were observed in all biomarkers, especially VEGF (pre: 125.16 ± 198.66, post: 80.29 ± 124.30, P = .06) and INF-γ (pre: 152.88 ± 312.71, post: 118.93 ± 158.79, P = .08), in the intervention group; only IL- α (pre: 332.15 ± 656.77, post: 255.12 ± 502.09, P = .20) decreased in the control group while all other biomarkers increased from baseline to end of study. A non-significant increase in 6MWT distance was observed in the intervention group, while a decrease was seen in the control group. Significant decreases in physical function, emotional wellbeing, and total composite scale on the FACIT-F were observed in the intervention group, possibly due to the isolation restrictions of COVID-19. Physical function on the SF-36 significantly increased in the control group. Conclusions Future studies with powered samples are needed to confirm the trends observed for inflammatory biomarkers and functional fitness.
Air pollution characteristics and human health risk assessment of underground parking garages in Xi’an, China
Authors: Wang Jianyue , Huang Yuyan , Bo Yanan , Zhang Yue , Zhang Liyuan 
Published: October 2022

Due to the rapid increase of population density and automobile vehicle numbers in mega-cities, large underground garages have become universal supporting facilities to meet the demand for parking spaces in the recently-built commercial complexes and high-rise residential communities. Natural ventilation was insufficient to discharge vehicle-induced pollutants out of the enclosed underground spaces, which could pose a potential threat to people’s health. This study aims to determine the spatial and temporal distribution characteristics of pollutants concentration and the health risk of underground parking garages (UPGs)’ staff and users. Field measurements were conducted on the air pollutants concentrations and the users’ exposure characteristics in 11 commercial UPGs and three high-rise residential UPGs with natural ventilation in Xi’an. The pollutants concentrations were higher in the afternoon and morning of commercial and high-rise residential UPGs. In general, the particulate matters (PM2.5 and PM10), HCHO, TVOC and BTEX (benzene, toluene, ethylbenzene and xylenes) concentrations in commercial and residential UPGs were 0.069/0.067 mg/m³, 0.12/0.097 mg/m³, 0.014/0.017 mg/m³, 1.8/1.8 mg/m³, 0.056/0.10 mg/m³, 0.19/0.29 mg/m³ and 0.41/0.49 mg/m³, respectively. TVOC and BTEX concentrations in UPGs significantly correlated with traffic volume ( p < 0.01). In different groups, the entropy values of carcinogenic and non-carcinogenic risks were: staffs > children travelling with adults > adults. In particular, occupational long-term (employee) exposure could lead to both carcinogenic and non-carcinogenic risks.
Mid-Term Outcomes of Cemented or Uncemented Total Hip Arthroplasty for Failed Proximal Femoral Nail Antirotation Following Intertrochanteric Femur Fractures: A Retrospective Observational Study
Authors: Huang Tao , Zhang Shi , Liu Xinhang , Lv Gang , Huang Heng , Wang Shuxin , Zhao Mingdong , Xiong Min , Yu Weiguang , Cheng Qiuxia , Huang Ting 
Published: October 2022

Introduction The aim of this retrospective study was to assess the clinical outcomes of cemented or uncemented total hip arthroplasty (CTHA or UTHA) following prior failed proximal femoral nail antirotation (PFNA) fixation in patients with intertrochanteric femur fractures (IFFs). Materials and methods Data from 244 patients with IFFs who experienced a conversion of PFNA to CTHA (n = 120) or to UTHA (n = 124) due to screw cut-out, mal/nonunion, or osteonecrosis during 2008-2018 were retrospectively analyzed. Follow-up occurred 1, 3, 6, and 12 months postoperatively and yearly thereafter. The primary outcome was the incidence of orthopedic complications; the secondary outcome was the Harris hip score (HHS). Results The median follow-up was 60 months (range, 50-67 months). The incidences of orthopedic complications were 10% in the PFNA to CTHA group and 19.3% in the PFNA to UTHA group (P = .040). Significant differences were also observed regarding the incidence of prosthesis revision (1.7% for PFNA to CTHA vs 7.2% for PFNA to UTHA, P = .036). From the three years after conversion surgery to the final follow-up, significant differences were detected in HHS between groups (each P < .05). At the final follow-up, a statistically significant difference was detected in the HHS (79.54±18.85 for PFNA to CTHA vs. 75.26±18.27 for PFNA to UTHA, P = .014). Conclusion The results of the study may demonstrate a significant statistical advantage with respect to the orthopedic complication rate and HHS in favor of CTHA compared to UTHA in patients with failed PFNA.
MagMin_PT: An Excel-based mineral classification and geothermobarometry program for magmatic rocks
Authors: Gündüz Mesut , Asan Kürşad 
Published: October 2022

ABSTRACTIgneous rock forming minerals carry valuable information from the deep earth that is not directly accessible at the surface. Each mineral represents the physico-chemical conditions at which various magmatic processes have occured over a wide range of depths from upper mantle to shallow crustal levels. These processes are cryptically inscribed in the whole-rock and mineral compositions (e.g. major elements, trace elements and isotopic ratios) and textures (equilibrium vs. disequilibrium features), together with intensive variables (e.g. pressure, P; temperature, T). Therefore, particular attention should be given to igneous minerals to understand better the processes that took place during their journey from the source through magma chambers and conduit systems to the Earth's surface.MagMin_PT is an Excel© based user-friendly program, designed to calculate mineral formulae and end-members, and to estimate pressure and temperature (e.g. geothermobarometry) from electron microprobe analytical data. The program operates using the most common igneous rock-forming minerals (olivine, pyroxene, amphibole, biotite, feldspar, magnetite, ilmenite, apatite and zircon), resulting in various classification diagrams and P–T diagrams. The program allows for whole-rock or glass composition to be entered together with the EPMA data to evalaute the equilibration status for most P–T calculation models. Fe2+ and Fe3+ estimation is routinely performed in MagMin_PT based on stoichiometric constraints, and to some extent using machine learning methods for different iron-bearing minerals. MagMin_PT is also able to carry calculations of fugacity, magmatic water content and saturation temperature. Graphical and numerical outputs produced by the program can be easily copied to other media for further processing.
Murine allogeneic CAR T cells integrated before or early after posttransplant cyclophosphamide exert antitumor effects
Authors: Patterson Michael T. , Khan Shanzay M. , Nunes Natalia S. , Fletcher Rochelle E. , Bian Jing , Hadjis Ashley D. , Eckhaus Michael A. , Mendu Suresh K. , de Paula Pohl Alessandra , Venzon David J. , Choo-Wosoba Hyoyoung , Ishii Kazusa , Qin Haiying , Fry Terry J. , Cam Maggie , Kanakry Christopher G. 
Published: October 2022

Abstract
Relapse limits the therapeutic efficacy both of chimeric antigen receptor (CAR) T cells and allogeneic hematopoietic cell transplantation (allo-HCT). Patients may undergo these therapies sequentially to prevent or treat relapsed malignancy. However, direct integration of the 2 therapies has been avoided over concerns for potential induction of graft-versus-host disease (GVHD) by allogeneic CAR T cells. We have shown in murine T-cell-replete MHC-haploidentical allo-HCT that suppressive mechanisms induced immediately after posttransplant cyclophosphamide (PTCy), given on days +3/+4, prevent GVHD induction by alloreactive T cells infused as early as day +5. Therefore, we hypothesized that allogeneic CAR T cells given in a similarly integrated manner in our murine MHC-haploidentical allo-HCT model may safely exert antitumor effects. Indeed, allogeneic anti-CD19 CAR T cells given early after (day +5) PTCy or even prior to (day 0) PTCy cleared leukemia without exacerbating the cytokine release syndrome occurring from the MHC-haploidentical allo-HCT or interfering with PTCy-mediated GVHD prevention. Meanwhile, CAR T-cell treatment on day +9 or day +14 was safe but less effective, suggesting a limited therapeutic window. CAR T cells infused before PTCy were not eliminated, but surviving CAR T cells continued to proliferate highly and expand despite PTCy. In comparison with infusion on day +5, CAR T-cell infusion on day 0 demonstrated superior clinical efficacy associated with earlier CAR T-cell expansion, higher phenotypic CAR T-cell activation, less CD4+CD25+Foxp3+ CAR T-cell recovery, and transcriptional changes suggesting increased activation of CD4+ CAR T cells and more cytotoxic CD8+ CAR T cells. This study provides mechanistic insight into PTCy’s impact on graft-versus-tumor immunity and describes novel approaches to integrate CAR T cells and allo-HCT that may compensate for deficiencies of each individual approach.
Rhinitis phenotypes and multimorbidities in the general population: the CONSTANCES cohort
Authors: Savouré Marine , Bousquet Jean , Leynaert Bénédicte , Renuy Adeline , Siroux Valérie , Goldberg Marcel , Zins Marie , Jacquemin Bénédicte , Nadif Rachel 
Published: October 2022

BackgroundScarce epidemiological studies have characterised allergic rhinitis (AR) and non-allergic rhinitis (NAR) in adults. In a population-based cohort, our aims were to 1) describe rhinitis, AR and NAR, and 2) explore how asthma and conjunctivitis may lead to the identification of novel rhinitis phenotypes.MethodsIn this cross-sectional analysis, current rhinitis was defined as present in the last 12 months using a questionnaire from the French CONSTANCES cohort. Participants with current rhinitis reporting nasal allergies were considered as AR, otherwise as NAR. We described AR and NAR phenotypes, and their phenotypes including co-occurrence with ever-asthma and ever-conjunctivitis.ResultsAmong the 20 772 participants included in this analysis (mean±sdage 52.6±12.6 years; 55.2% female), crude prevalences of AR and NAR were 28.0% and 10.9%. AR participants more frequently reported persistent rhinitis (31.6%versus25.1%) and moderate-to-severe rhinitis (40.1%versus24.2%) than NAR participants. Among AR or NAR participants, those with ever-asthma reported more moderate-to-severe rhinitis. Participants with AR, ever-asthma and ever-conjunctivitis had an earlier age of rhinitis onset, more severe rhinitis and higher eosinophil counts than participants in other groups. Results were replicated in another cohort.ConclusionsIn this large population-based cohort, 40% reported current rhinitis, with a lower prevalence of moderate-to-severe rhinitis than in clinical practice. For the first time in a general adult population, we showed that AR and NAR alone or in combination with asthma or in combination with asthma and conjunctivitis are different phenotypes. These results provide new insights on how best to manage rhinitis and its multimorbidities.
Baseline clusters and the response to positive airway pressure treatment in obstructive sleep apnoea patients: longitudinal data from the European Sleep Apnea Database cohort
Authors: Yassen Ashraf , Coboeken Katrin , Bailly Sébastien , Burghaus Rolf , Buskova Jitka , Dogas Zoran , Drummond Marta , Gouveris Haralampos , Joppa Pavol , Lippert Joerg , Lombardi Carolina , Mihaicuta Stefan , Pépin Jean Louis , Zou Ding , Hedner Jan , Grote Ludger ,   the ESADA collaborators, Steiropoulos P. , Verbraecken J. , Petiet E. , Trakada G. , Fietze I. , Penzel T. , Laharnar N. , Ludka O. , Bouloukaki I. , Schiza S. , McNicholas W.T. , Ryan S. , Riha R.L. , Kvamme J.A. , Grote L. , Hedner J. , Zou D. , Pevernagie D. , Bailly S. , Pépin J.L. , Tamisier R. , Hein H. , Basoglu O.K. , Tasbakan M.S. , Buskova J. , Joppa P. , Staats R. , Testelmans D. , Gouveris H. , Ludwig K. , Lombardi C. , Parati G. , Bonsignore M.R. , Fanfulla F. , Petitjean M. , Roisman G. , Drummond M. , van Zeller M. , Treml M. , Randerath W. , Dogas Z. , Pecotic R. , Pataka A. , Mihaicuta S. , Anttalainen U. , Saaresranta T. , Sliwinski S. 
Published: October 2022

IntroductionThe European Sleep Apnea Database was used to identify distinguishable obstructive sleep apnoea (OSA) phenotypes and to investigate the clinical outcome during positive airway pressure (PAP) treatment.MethodProspective OSA patient data were recruited from 35 sleep clinics in 21 European countries. Unsupervised cluster analysis (anthropometrics, clinical variables) was performed in a random sample (n=5000). Subsequently, all patients were assigned to the clusters using a conditional inference tree classifier. Responses to PAP treatment change in apnoea severity and Epworth sleepiness scale (ESS) were assessed in relation to baseline patient clusters and at short- and long-term follow-up.ResultsAt baseline, 20 164 patients were assigned (mean age 54.1±12.2 years, 73% male, median apnoea–hypopnoea index (AHI) 27.3 (interquartile range (IQR) 14.1–49.3) events·h−1, and ESS 9.8±5.3) to seven distinct clusters based on anthropometrics, comorbidities and symptoms. At PAP follow-up (median 210 [IQR 134–465] days), the observed AHI reduction (n=1075) was similar, whereas the ESS response (n=3938) varied: largest reduction in cluster 3 (young healthy symptomatic males) and 6 (symptomatic males with psychiatric disorders, −5.0 and −5.1 units, respectively (all p<0.01), limited reduction in clusters 2 (obese males with systemic hypertension) and 5 (elderly multimorbid obese males, −4.2 (p<0.05) and −3.7 (p<0.001), respectively). Residual sleepiness in cluster 5 was particularly evident at long-term follow-up (p<0.05).ConclusionOSA patients can be classified into clusters based on clinically identifiable features. Importantly, these clusters may be useful for prediction of both short- and long-term responses to PAP intervention.
A genome-wide landscape of mRNAs, lncRNAs, circRNAs and miRNAs during intramuscular adipogenesis in cattle
Authors: Yang Xinran , Ma Xinhao , Mei Chugang , Zan Linsen 
Published: October 2022

Abstract
Background
Intramuscular preadipocyte differentiation plays a critical role in bovine intramuscular fat (IMF) deposition. However, the roles of different RNAs, including mRNAs, circRNAs, lncRNAs and miRNAs, in regulating the adipogenic differentiation of intramuscular preadipocytes remain largely unclear.

Results
In the present study, a whole transcriptome sequencing and analysis, including the analysis of mRNAs, circRNAs, lncRNAs and miRNAs, during different differentiation stages (0, 3, 6, and 9 d) of intramuscular preadipocytes from Qinchuan cattle was performed. All samples were prepared with 3 biological replicates. Here, a total of 27,153 mRNAs, 14,070 circRNAs, 7035 lncRNAs, and 427 miRNAs were annotated. Among them, we identified 4848 differentially expressed mRNAs (DEMs), 181 DE circRNAs (DECs), 501 DE lncRNAs (DELs) and 77 DE miRNAs (DEmiRs) between 0 d and other differentiation days (3, 6, and 9 d). GO and KEGG functional enrichment analyses showed that these differentially expressed genes were mainly enriched in cell differentiation, fat metabolism and adipogenesis-related pathways. Furthermore, weighted gene coexpression network analysis (WGCNA) and co-expression network analysis screened out multiple important mRNAs, circRNAs and lncRNAs related to intramuscular adipogenesis. Based on the competing endogenous RNA (ceRNA) regulatory mechanism, we finally identified 24 potential ceRNA networks and 31 potential key genes, including FOXO1/miR-330/circRNA2018/MSTRG.20301, GPAM/miR-27b/ciRNA489 and SESN3/miR-433/circRNA2627MSTRG.20342.

Conclusions
This study provides new insights into the differential expression patterns of different transcript types (i.e., mRNAs, circRNAs, lncRNAs and miRNAs) in intramuscular preadipocyte differentiation. Our findings provide data support for studying the molecular mechanism of key mRNAs and noncoding RNAs in IMF deposition, and provide new candidate markers for the molecular breeding of beef cattle.
Right displacement of trachea to reduce right bronchial misplacement of left double lumen tube: a prospective, double-blind, randomized study
Authors: Guan Jianqiang , Zhu Wenxiu , Xiao Xue , Huang Ziyan , Xing Jibin , Hei Ziqing , Zhang Yihan , Yao Weifeng 
Published: October 2022

Abstract
Background
Misplacement of double-lumen endobronchial tubes (DLTs) during bronchial intubation, especially when bronchoscopy guidance is not applicable, threatens effective lung isolation and brings about airway injury during reposition. We aimed to examine whether a novel maneuver called right tracheal displacement (RTD) can reduce left-sided DLT misplacement during first-attempt intubation without bronchoscopy guidance.

Methods
Patients that underwent thoracic surgeries requiring one-lung ventilation during November 2020 to January 2021 were recruited and randomized into control and RTD group, with 54 cases in each group. The primary outcomes included the incidence of DLT misplacement and the time to complete desired bronchial intubation. The secondary outcomes included mucosal injury, sore throat and hoarseness upon emergence and at 24 h post-operatively.

Result
The incidence of DLT misplacement in RTD group was significantly lower compared to control group (0% vs. 16.7%) The time to complete bronchial intubation was also significantly shortened in RTD group compared to control (52.88 ± 9.36 s vs. 63.04 ± 20.02 s). The incidence of mucosal injury, sore throat and hoarseness were comparable between two groups.

Conclusion
RTD maneuver can effectively improve the success rate of first-attempt proper DLT positioning and shorten the time required by bronchial intubation.

Trial registration
This prospective, double-blind, randomized study has completed the registration of the Chinese Clinical Trial Center at 2/11/2020 with the registration number ChiCTR2000040212. It was conducted from 26/11/2020 to 31/7/2021 in third affiliated hospital of Sun Yat-sen university.