bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Different Wheat-Based Diets and Corn Meal Addition on Development Parameters ofEphestia kuehniella(Zeller, 1879) (Lepidoptera: Pyralidae)
Authors: Parra L M , Garcia A G , Alves G R , Magro S R , Parra J R P 
Published: April 2022

AbstractThe expansion of Integrated Pest Management (IPM), including biological control, has had several positive consequences for the agricultural environment and participants in the production chain. To enable successful operation and applications of biological control, production of insects used for rearing natural enemies (parasitoids and predators) must be optimized to reduce time and costs and improve production both qualitatively and quantitatively. The present study evaluated the effect of wheat varieties, the main component of artificial diets for Ephestia kuehniella, on the reproductive performance and biological parameters of this flour moth, which is used for mass production of Trichogramma spp. (Hymenoptera: Trichogrammatidae) and other parasitoids and predators. Four varieties of wheat were compared: BRS 327, BRS Marcante, BRS Parrudo, and KBR, with and without the addition of corn E. kuehniella reared on 97% BRS 327 wheat flour + 3% nutritional yeast had the best biological parameters and substitution of corn for about half of the wheat increased the number of eggs per female.
Current practice of pharmacological treatment for hyperactive delirium in terminally ill cancer patients: results of a nationwide survey of Japanese palliative care physicians and liaison psychiatrists
Authors: Matsuda Yoshinobu , Morita Tatsuya , Oya Kiyofumi , Tagami Keita , Naito Akemi Shirado , Kashiwagi Hideyuki , Otani Hiroyuki 
Published: April 2022

Abstract

Objective
The objective of this survey was to identify areas where doctors have divergent practices in pharmacological treatment for hyperactive delirium in terminally ill patients with cancer.

Methods
We conducted a survey of Japanese palliative care physicians and liaison psychiatrists. Inquiries were made regarding: (i) choice of drug class in the first-line treatment, (ii) administration methods of the first-line antipsychotic treatment, (iii) starting dose of antipsychotics in the first line treatment and maximum dose of antipsychotics in refractory delirium, and (iv) choice of treatment when the first-line haloperidol treatment failed. Respondents used a five-point Likert scale.

Results
Regarding choice of drug class in the first-line treatment, more doctors reported that they ‘frequently’ or ‘very frequently’ use antipsychotics only than antipsychotics and benzodiazepine (oral: 73.4 vs. 12.2%; injection: 61.3 vs. 11.6%, respectively). Regarding administration methods of the first-line antipsychotic treatment, the percentage of doctors who reported that they used antipsychotics as needed and around the clock were 55.4 and 68.8% (oral), 49.2 and 45.4% (injection), respectively. There were different opinions on the maximum dose of antipsychotics in refractory delirium. Regarding the choice of treatment when the first-line haloperidol treatment failed, the percentage of doctors who reported that they increased the dose of haloperidol, used haloperidol and benzodiazepines, and switched to chlorpromazine were 47.0, 32.1 and 16.4%, respectively.

Conclusions
Doctors have divergent practices in administration methods of the first-line antipsychotic treatment, maximum dose of antipsychotics, and choice of treatment when the first-line haloperidol treatment failed. Further studies are needed to determine the optimal treatment.
Subsequent Primary Cancer Risk Among 5-Year Survivors of Adolescent and Young Adult Cancers
Authors: Sung Hyuna , Siegel Rebecca L , Hyun Noorie , Miller Kimberly D , Yabroff K Robin , Jemal Ahmedin 
Published: April 2022

Abstract

Background
A comprehensive examination of the incidence and mortality of subsequent primary cancers (SPCs) among adolescent and young adult (AYA) cancer survivors in the United States is lacking.

Methods
Cancer incidence and mortality among 170 404 cancer survivors of 5 or more years who were aged 15-39 years at first primary cancer diagnosis during 1975-2013 in 9 Surveillance, Epidemiology, and End Results registries were compared with those in the general population using standardized incidence ratio (SIR), absolute excess incidence (AEI), standardized mortality ratio (SMR), and absolute excess mortality (AEM).

Results
During a mean follow-up of 14.6 years, 13 420 SPC cases and 5008 SPC deaths occurred among survivors (excluding the same site as index cancer), corresponding to 25% higher incidence (95% confidence interval [CI] = 1.23 to 1.27, AEI = 10.8 per 10 000) and 84% higher mortality (95% CI = 1.79 to 1.89, AEM = 9.2 per 10 000) than that in the general population. Overall, SPC risk was statistically significantly higher for 20 of 29 index cancers for incidence and 26 for mortality, with the highest SIR among female Hodgkin lymphoma survivors (SIR = 3.05, 95% CI = 2.88 to 3.24, AEI = 73.0 per 10 000) and the highest SMR among small intestine cancer survivors (SMR = 6.97, 95% CI = 4.80 to 9.79, AEM = 64.1 per 10 000). Type-specific SPC risks varied substantially by index cancers; however, SPCs of the female breast, lung, and colorectum combined constituted 36% of all SPC cases and 39% of all SPC deaths, with lung cancer alone representing 11% and 24% of all cases and deaths, respectively.

Conclusion
AYA cancer survivors are almost twice as likely to die from a new primary cancer as the general population, highlighting the need for primary care clinicians to prioritize cancer prevention and targeted surveillance strategies in these individuals.
Combining a small urinary catheter with an endo mini-retractor: a novel technique for laparoscopic selective vascular control
Authors: Luvira Vor , Junyavoraluk Apichaya , Tipwaratorn Theerawee 
Published: April 2022

Abstract
The Pringle maneuver using a urinary catheter has been described and proven to be one of the best methods for laparoscopic intracorporeal vascular control. Selective vascular control provides many advantages over total inflow occlusion by the Pringle maneuver. However, laparoscopic selective vascular control by urinary catheter has not been described. We, herein, describe laparoscopic selective vascular control using a combined small urinary catheter with an endo mini-retractor, which inserted in a new way, named ‘The J-shaped Loop’. This method makes the instrument more compact so we can selectively control the vascular pedicle. When selective vascular occlusion is desired, the loop is tightened and the tension is held just by the catheter itself. This novel technique is simple, safe, effective and reproducible, and, therefore, can be used as a good alternative to other intracorporeal techniques for laparoscopic liver resection.
The Milky Way tomography with APOGEE: intrinsic density distribution and structure of mono-abundance populations
Authors: Lian Jianhui , Zasowski Gail , Mackereth Ted , Imig Julie , Holtzman Jon A , Beaton Rachael L , Bird Jonathan C , Cunha Katia , Fernández-Trincado José G , Horta Danny , Lane Richard R , Masters Karen L , Nitschelm Christian , Roman-Lopes A 
Published: April 2022

ABSTRACT
The spatial distribution of mono-abundance populations (MAPs, selected in [Fe/H] and [Mg/Fe]) reflect the chemical and structural evolution in a galaxy and impose strong constraints on galaxy formation models. In this paper, we use APOGEE data to derive the intrinsic density distribution of MAPs in the Milky Way, after carefully considering the survey selection function. We find that a single exponential profile is not a sufficient description of the Milky Way’s disc. Both the individual MAPs and the integrated disc exhibit a broken radial density distribution; densities are relatively constant with radius in the inner Galaxy and rapidly decrease beyond the break radius. We fit the intrinsic density distribution as a function of radius and vertical height with a 2D density model that considers both a broken radial profile and radial variation of scale height (i.e. flaring). There is a large variety of structural parameters between different MAPs, indicative of strong structure evolution of the Milky Way. One surprising result is that high-α MAPs show the strongest flaring. The young, solar-abundance MAPs present the shortest scale height and least flaring, suggesting recent and ongoing star formation confined to the disc plane. Finally we derive the intrinsic density distribution and corresponding structural parameters of the chemically defined thin and thick discs. The chemical thick and thin discs have local surface mass densities of 5.62 ± 0.08 and 15.69 ± 0.32 M⊙pc−2, respectively, suggesting a massive thick disc with a local surface mass density ratio between thick to thin disc of 36 per cent.
Testing feedback from star clusters in simulations of the Milky Way formation
Authors: Brown Gillen , Gnedin Oleg Y 
Published: April 2022

ABSTRACT
We present a suite of galaxy formation simulations that directly model star cluster formation and disruption. Starting from a model previously developed by our group, here we introduce several improvements to the prescriptions for cluster formation and feedback, then test these updates using a large suite of cosmological simulations of Milky Way mass galaxies. We perform a differential analysis with the goal of understanding how each of the updates affects star cluster populations. Two key parameters are the momentum boost of supernova feedback fboost and star formation efficiency per free-fall time ϵff. We find that fboost has a strong influence on the galactic star formation rate, with higher values leading to less star formation. The efficiency ϵff does not have a significant impact on the global star formation rate, but dramatically changes cluster properties, with increasing ϵff leading to a higher maximum cluster mass, shorter age spread of stars within clusters, and higher integrated star formation efficiencies. We also explore the redshift evolution of the observable cluster mass function, finding that most massive clusters have formed at high redshift z &gt; 4. Extrapolation of cluster disruption to z = 0 produces good agreement with both the Galactic globular cluster mass function and age–metallicity relation. Our results emphasize the importance of using small-scale properties of galaxies to calibrate subgrid models of star cluster formation and feedback.
DEPCOD: a tool to detect and visualize co-evolution of protein domains
Authors: Ji Fei , Bonilla Gracia , Krykbaev Rustem , Ruvkun Gary , Tabach Yuval , Sadreyev Ruslan I 
Published: April 2022

Abstract
Proteins with similar phylogenetic patterns of conservation or loss across evolutionary taxa are strong candidates to work in the same cellular pathways or engage in physical or functional interactions. Our previously published tools implemented our method of normalized phylogenetic sequence profiling to detect functional associations between non-homologous proteins. However, many proteins consist of multiple protein domains subjected to different selective pressures, so using protein domain as the unit of analysis improves the detection of similar phylogenetic patterns. Here we analyze sequence conservation patterns across the whole tree of life for every protein domain from a set of widely studied organisms. The resulting new interactive webserver, DEPCOD (DEtection of Phylogenetically COrrelated Domains), performs searches with either a selected pre-defined protein domain or a user-supplied sequence as a query to detect other domains from the same organism that have similar conservation patterns. Top similarities on two evolutionary scales (the whole tree of life or eukaryotic genomes) are displayed along with known protein interactions and shared complexes, pathway enrichment among the hits, and detailed visualization of sources of detected similarities. DEPCOD reveals functional relationships between often non-homologous domains that could not be detected using whole-protein sequences. The web server is accessible at http://genetics.mgh.harvard.edu/DEPCOD.
A Daily Assessment Study of Smoking Cessation After a Head and Neck Cancer Diagnosis
Authors: Borger Tia , Shelton Brent J , Valentino Joseph , Ostroff Jamie S , Cummings Kenneth Michael , Studts Jamie L , Carpenter Matthew J , Burris Jessica L 
Published: April 2022

Abstract

Introduction
This intensive longitudinal study describes key events in the process of smoking cessation after a new head and neck cancer (HNC) diagnosis. Prior longitudinal studies show some cancer patients quit, while others continue to smoke, but details about the pattern in which these discrete outcomes arise are scarce. This study is meant to help rectify this gap in the literature.

Aims and Methods
Participants were 42 HNC patients who reported current smoking at enrollment. Participants were recruited from an outpatient oncology clinic and completed a baseline questionnaire prior to begin a 30-day daily assessment.

Results
Few participants (9.52%) achieved 30-day continuous abstinence from smoking. On average, participants reported 9.64 ± 11.93 total days of abstinence. Nearly, all (94.44%, n = 34) participants made at least one quit attempt, with an average of 16.94 ± 11.30 quit attempt days. Fewer participants were able to achieve a 24-hour quit attempt (52.78%, n = 19), with a corresponding average of 5.50 ± 8.69 24-hour days. The median time to first 24-hour quit attempt was 13 days after enrollment. Based on smoking behavioral patterns, participants were categorized into five groups, the most common being “persistent attempters,” which involved unsuccessful quit attempts throughout the study. Only 45% of participants (n = 19) used evidence-based treatment, the most common being cessation medication.

Conclusions
This intensive longitudinal study found that cancer diagnosis can spur a lot of efforts to quit smoking. Unfortunately, this study suggests that many quit attempts are short lived, possibly a result of an absence or insufficient use of evidence-based treatments.

Implications
For adults who are current smokers at the time of cancer diagnosis, there is a high likelihood of persistent cigarette smoking and use of other tobacco products in the weeks and months after a cancer diagnosis. Furthermore, this study shows that while a lot of quit attempts may occur, few are successful, which may be partly attributable to the low use of evidence-based tobacco treatment. Future research with cancer patients should aim to identify predictors of quit attempts and abstinence as well as treatment utilization.
Sinapate Esters Mediate UV-B-Induced Stomatal Closure by Regulating Nitric Oxide, Hydrogen Peroxide, and Malate Accumulation in Arabidopsis thaliana
Authors: Li Weiqiang , Sun Yaru , Li Kun , Tian Hongtao , Jia Jiangtao , Zhang Hongyu , Wang Yaping , Wang Hong , Bi Baodi , Guo Jinggong , Tran Lam-Son Phan , Miao Yuchen 
Published: April 2022

Abstract
Sinapate esters, which are induced in plants under ultraviolet-B (UV-B) irradiation, have important roles not only in the protection against UV-B irradiation but also in the regulation of stomatal closure. Here, we speculated that sinapate esters would function in the stomatal closure of Arabidopsis thaliana in response to UV-B. We measured the stomatal aperture size of the wild-type (WT) and bright trichomes 1 (brt1) and sinapoylglucose accumulator 1 (sng1) mutants under UV-B irradiation; the latter two mutants are deficient in the conversion of sinapic acid to sinapoylglucose (SG) and SG to sinapoylmalate (SM), respectively. Both the brt1 and sng1 plants showed smaller stomatal apertures than the WT under normal light and UV-B irradiation conditions. The accumulation of SM and malate were induced by UV-B irradiation in WT and brt1 plants but not in sng1 plants. Consistently, exogenous malate application reduced UV-B-induced stomatal closure in WT, brt1 and sng1 plants. Nonetheless, levels of reactive oxygen species (ROS), nitric oxide (NO) and cytosolic Ca2+ were higher in guard cells of the sng1 mutant than in those of the WT under normal white light and UV-B irradiation, suggesting that disturbance of sinapate metabolism induced the accumulation of these signaling molecules that promote stomatal closure. Unexpectedly, exogenous sinapic acid application prevented stomatal closure of WT, brt1 and sng1 plants. In summary, we hypothesize that SG or other sinapate esters may promote the UV-B-induced malate accumulation and stomatal closure, whereas sinapic acid inhibits the ROS-NO pathway that regulates UV-B-induced cytosolic Ca2+ accumulation and stomatal closure.
Pain Location and Exacerbating Activities Associated with Treatment Success Following Basivertebral Nerve Ablation: An Aggregated Cohort Study of Multicenter Prospective Clinical Trial Data
Authors: McCormick Zachary L , Sperry Beau P , Boody Barret S , Hirsch Joshua A , Conger Aaron , Harper Katrina , Lotz Jeffrey C , Burnham Taylor R 
Published: April 2022

AbstractObjectiveDevelop pain location “maps” and investigate the relationship between low back pain (LBP)-exacerbating activities and treatment response to basivertebral nerve radiofrequency ablation (BVN RFA) in patients with clinically suspected vertebral endplate pain (VEP).DesignAggregated cohort study of 296 patients treated with BVN RFA at 33 centers in three prospective trials.MethodsParticipant demographics, pain diagrams, and LBP-exacerbating activities were analyzed for predictors using stepwise logistic regression. Treatment success definitions were: (1) ≥50% LBP visual analog scale (VAS), (2) ≥15-point Oswestry Disability Index (ODI), and (3) ≥50% VAS or ≥15-point ODI improvements at 3 months post-BVN RFA.ResultsMidline LBP correlated with BVN RFA treatment success in individuals with clinically-suspected VEP. Duration of pain ≥5 years (OR 2.366), lack of epidural steroid injection within 6 months before BVN RFA (OR 1.800), lack of baseline opioid use (OR 1.965), LBP exacerbation with activity (OR 2.099), and a lack of LBP with spinal extension (OR 1.845) were factors associated with increased odds of treatment success. Regressions areas under the curve (AUCs) were under 70%, indicative of low predictive value.ConclusionsThis study demonstrates that midline LBP correlates with BVN RFA treatment success in individuals with VEP. While none of the regression models demonstrated strong predictive value, the pain location and exacerbating factors identified in this analysis may aid clinicians in identifying patients where VEP should be more strongly suspected. The use of objective imaging biomarkers (Type 1 and/or 2 Modic changes) and a correlating presentation of anterior spinal element pain remain the most useful patient selection factors for BVN RFA.
Ultrasound-Guided Gluteal Fascial Plane Block for the Treatment of Chronic Refractory Greater Trochanteric Pain Syndrome — Technique Description and Anatomical Correlation Study
Authors: Ferreira-Dos-Santos Guilherme , Hurdle Mark Friedrich B , Tran John , Eldrige Jason S , Clendenen Steven R , Agur Anne M R 
Published: April 2022

Abstract

Introduction
Greater trochanteric pain syndrome may often mimic pain generated from other sources. However, it is most commonly caused by gluteus medius and gluteus minimus tendinopathy or tear. The purpose of this technical report was to: 1) describe the ultrasound-guided fascial plane block technique targeting the superior gluteal nerve in the plane between gluteus medius/gluteus minimus to treat moderate-to-severe, chronic, refractory greater trochanteric pain syndrome; 2) anatomically correlate the procedure with cadaveric dissections demonstrating the structures being imaged and the tissues along the needle trajectory; 3) demonstrate the feasibility of the technique with serial dissection of one cadaveric specimen following injection with color dye.

Technique description
The ultrasound-guided fascial plane block targeting the superior gluteal nerve to treat moderate-to-severe, chronic, refractory greater trochanteric pain syndrome has been outlined with supporting ultrasound scans and anatomical dissections. The cadaveric dissections are correlated to the ultrasound scans of a healthy volunteer and provide visualization of the tissues in the needle trajectory. The feasibility study in a cadaveric specimen showed adequate stain of the superior gluteal nerve without spread to the piriformis muscle belly, the sciatic nerve, or the inferior gluteal nerve.

Conclusions
This ultrasound-guided fascial plane block is a feasible option for blocking the superior gluteal nerve without inadvertent involvement of the sciatic and inferior gluteal nerves. Further randomized controlled clinical trials are necessary to assess the clinical efficacy of the gluteus medius/gluteus minimus fascial plane block to treat moderate-to-severe, chronic, refractory greater trochanteric pain syndrome.
Curved domain-wall fermions
Authors: Aoki Shoto , Fukaya Hidenori 
Published: April 2022

Abstract
We consider fermion systems on a square lattice with a mass term having a curved domain-wall. Like conventional flat domain-wall fermions, massless and chiral edge states appear on the wall. In the cases of S1 and S2 domain-walls embedded into flat hypercubic lattices, we find that these edge modes feel gravity through the induced spin or spinc connections. The gravitational effect is encoded in the Dirac eigenvalue spectrum as a gap from zero. In the standard continuum extrapolation of the square lattice, we find good agreement with the analytic prediction in the continuum theory. We also find that the rotational symmetry of the edge modes is automatically recovered in the continuum limit. Subject Index B38
A case of acquired angioedema
Authors: Zwanziger Arielle D. 
Published: April 2022

ABSTRACT
Acquired angioedema is a rare disorder characterized by nonurticarial angioedema secondary to deficiency or altered activity of C1-esterase inhibitor protein. This article describes a patient whose recurrent angioedema was initially diagnosed as angiotensin-converting enzyme (ACE) inhibitor-induced angioedema. However, after further testing, she was diagnosed with acquired angioedema and subsequently treated with a synthetic bradykinin B2-receptor antagonist.
Updates on the diagnosis and management of celiac disease
Authors: Soltesz Kristina , Mosebach Jessica , Paruch Emily , Covino Jean 
Published: April 2022

ABSTRACT
Celiac disease is a chronic autoimmune enteropathy affecting about 1% of the population. Gluten ingestion triggers an immune response in genetically susceptible patients, resulting in intestinal and extraintestinal disease manifestations. Current recommendations for diagnosis include serology for celiac-specific antibodies to transglutaminase, endomysium, and deamidated gliadin, and IgA serology. New highly accurate point-of-care tests can efficiently screen for celiac disease and improve the diagnostic timeframe. Definitive diagnosis is most commonly made via biopsy of the small bowel showing villous atrophy. A gluten-free diet with micronutrient supplementation is the only recommended treatment for celiac disease. Primary care providers must be able to recognize screening indications, refer patients appropriately, and provide proper patient education and follow-up.