bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fear of Cancer Recurrence Is Highly Prevalent and Linearly Associates With Anxiety and Depression in Chinese Breast Cancer Patients
Authors: Li Zhensheng , Li Yue , Liu Yunjiang , Zhang Jun , Ji Xiaohui , Zhao Zhiping , Duan Xuejuan , Geng Wenhui , Yin Junpu 
Published: January 2022

Abstract
Objective: To characterize the fear of cancer recurrence (FCR) and its relationship with anxiety and depression and quality of life (QoL) among Chinese breast cancer (BC) patients in China. Methods: Patients completed the questionnaires of QLQ-C30, QLQ-BR32 and HAD to assess FCR, QoL, anxiety and depression before radiotherapy. A cross-sectional analysis was performed. Chi-square and non-parametric tests and multivariate ordinal logistic regressions (mOLR) were utilized for reference analysis. Final covariates included age, BMI, TNM, surgery, chemotherapy, pain, and sleep disturbance. Results: From July 2015 to December 2016, 463 patients were prospectively enrolled. Their age mean (range) were 47 (19 - 89) years old. In total, 327 patients (70.6%) reported having FCR ‘a little bit’ (51.2%), ‘some’ (12.1%) and ‘very much’ (7.3%) in the past week. FCR severity ordered above (incl. ‘no’) was associated with anxiety score (median 1.5, 5.0, 7.0, 8.5 and level (‘abnormal’ rate 0%, 3.4%, 12.5%, 26.5%), depression score (median 2.0, 4.0, 6.0, 6.5) and level (‘abnormal’ rate 2.2%, 3.4%, 5.4%, 17.7%) (all p<0.001). mOLR showed that compared to ‘no’, three higher levels of FCR were associated with one level increase of anxiety with OR (p) as 1.983 (0.076), 4.291 (0.001), 8.282 (<0.001) and depression with OR (p) as 1.903 (0.062), 2.262 (0.065), 4.205 (0.004), respectively. FCR severity also was inversely associated with most QoL function scores (p<0.001). Conclusions: FCR was prevalent in Chinese BC patients and linearly associated with anxiety, depression and low QoL. It seems that a single-item question for FCR is a valid surrogate tool for distress screening in this population.
Potential HNF1A-AS1/miR-214/INHBA signal regulation mechanism in colorectal cancer based on bioinformatics analysis and validation
Authors: Zhang Xuan , Wu Tao , Ding Rong , Qin Rujia , Zhou Yongchun , Wang Xiaoxiong , Shang ZhongJun , Li GuoYu , Dong Chao , Yang Renfang , Li Jinsha , Li Yunfeng 
Published: January 2022

Abstract
Preceding studies have identified that noncoding RNA plays a significant role in the occurrence and development of tumors. Colorectal cancer (CRC) has attracted increasing attention due to its high incidence and mortality rate. Based on Cancer Genome Atlas (TCGA) database analysis, it was found that compared with normal tissues, HNF1A-AS1 and INHBA were highly expressed in CRC tissues; miR-214 was relatively low expressed, and it is predicted to specifically target the3' untranslated region (3'UTR region) of INHBA. Besides, the result was consistent with the quantitative reverse transcription PCR (RT-qPCR) verification results of 17 CRC cases and adjacent tissues collected clinically. Western Blot (WB) manifested that INHBA protein was highly expressed in CRC tissues, which was consistent with the results of CRC cell lines (HT29, SW480). Immunohistochemical (IHC) staining demonstrated that INHBA protein was brownish yellow, overwhelming majority of INHBA protein were located in the cytoplasm, and expression level was significantly higher than that in adjacent tissues. Based on previous studies, the biological process of INHBA-mediated TGF-β/Smad signaling pathway inducing the proliferation and invasion of CRC has been partially confirmed, but the upstream signaling molecules and mechanisms which regulating INHBA remain unclear. Herein, benefiting from bioinformatics, preliminary experimental results and previous research, they provide basis for the follow-up study on the regulation of HNF1A-AS1/miR-214/INHBA signal axis in CRC.
Effect of different basin materials on the performance of hemispherical distiller with mirrors and energy storage material
Authors: Attia Mohammed El Hadi , Essa Fadl Abdelmonem , Abdelgaied Mohamed , Kabeel Abd elnaby 
Published: January 2022

Abstract
Numerous studies are being conducted on solar desalination systems with creating new designs to improve the efficiency and yield of these systems. Hemispherical solar still has a relatively large throughput because of its large exposure and evaporation surface areas compared to the other distiller designs. To get the optimal conditions of the parameters that provide the highest productivity of the hemispherical still, three hemispherical basin stills were fabricated and tested. The experiments were performed in three stages: In the first one, the traditional hemispherical solar still THSS (a reference distiller) was compared by THSS with internal reflective mirrors (THSS-IRM). In the second stage, the effect of using different basin metals (THSS with basin metal of zinc (THSS-IRMZ) and basin metal of copper (THSS-IRMC)) with internal reflective mirrors was studied. In the third stage, the two distillers were investigated under using energy storage medium (30 g/L sand grains for each). The THSS with internal reflective mirrors, basin metal of zinc, and energy storage medium is abbreviated by THSS-IRMZSG. Also, THSS with internal reflective mirrors, basin metal of copper, and energy storage medium is abbreviated by THSS-IRMCSG. Moreover, THSS with internal reflective mirrors and energy storage medium is abbreviated by THSS-IRMSG. The results showed that the combination of using internal reflective mirrors, basin material (copper) and energy storage medium provided the best improvement of hemispherical distillation device. The maximum cumulative yield of THSS-IRMCSG was 11.9 L/m².day, while the reference distillation device gave a total yield of 4.65 L/m².day. So, the productivity was improved by around 156%.
Nationwide Survey on Family-perceived Experiences of Patients With Cancer of Unknown Primary Site
Authors: Ishida Kyoko , SATO Kazuki , KOMATSU Hirokazu , MORITA Tatsuya , AKECHI Tatsuo , UCHIDA Megumi , MASUKAWA Kento , IGARASHI Naoko , KIZAWA Yoshiyuki , TSUNETO Satoru , SHIMA Yasuo , MIYASHITA Mitsunori , ANDO Shoko 
Published: January 2022

Abstract
Purpose: Cancer of unknown primary site (CUP) is an aggressive disease with poor prognosis. As research on the experiences of CUP patients and their families is scarce, this study aimed to compare the family-perceived burden of CUP with that of common cancers (lung, colon, and stomach cancer). Additional aims were to explore the association between family-perceived burden and CUP patients’ quality of life (QOL) at end-of-life and family depression.Methods: This was a pre-planned secondary analysis of nationwide cross-sectional survey data from the bereaved family members of patients with cancer who died at 286 institutions. The major measurements were the eight-item family-perceived Burden scale (comprising specialist access, uncertainty, and prolonged diagnosis), Good Death Inventory, and Patient Health Questionnaire 9.Results: Of the total 27,591 survey responses, we analyzed 97 and 717 responses from the family members of patients with CUP and common cancer, respectively. The families of CUP patients scored significantly higher on all three burden subscales than those of common cancer patients (effect sizes: specialist access subscale, 0.3; uncertainty subscale, 0.66; and prolonged diagnosis subscale, 0.69; adjusted P < 0.01). Greater family Burden was significantly associated with lower patient QOL and higher family depression. Burden was significantly associated with being a spouse, second opinion consultation, and diagnosis period of >1 month.Conclusion: The families of CUP patients experience poor specialist access, greater uncertainty, and a prolonged diagnosis. They should be cared for from the initial stages to establish access to specialists, obtain an early diagnosis, and reduce uncertainty.
Residue Regulating Homotopy Method for Strongly Nonlinear Oscillator
Authors: Song Penghui , Zhang Wenming , Shao Lei 
Published: January 2022

Abstract
It is highly desired yet challenging to obtain analytical approximate solutions to strongly nonlinear oscillators accurately and efficiently. Here we propose a new approach, which combines the homtopy concept with a “residue-regulating” technique to construct a continuous homotopy from an initial guess solution to a high-accuracy analytical approximation of the nonlinear problems, namely the residue regulating homotopy method (RRHM). In our method, the analytical expression of each order homotopy-series solution is associated with a set of base functions which are pre-selected or generated during the previous order of approximations, while the corresponding coefficients are solved from deformation equations specified by the nonlinear equation itself and auxiliary residue functions. The convergence region, rate and final accuracy of the homotopy are controlled by a residue-regulating vector and an expansion threshold. General procedures of implementing RRHM are demonstrated using the Duffing and Van der Pol-Duffing oscillators, where approximate solutions containing abundant frequency components are successfully obtained, yielding significantly better convergence rate and performance stability compared to the other conventional homotopy-based methods.
Grinding Performance Integrated Experimental Evaluation on Alumina Ceramics with Leaf-Vein Bionic Grinding Wheel
Authors: Li Chao , Duan Jia , Xiaohong Zhang , Shi Zhaoyao , Yuchi Guangzhi , Zhang Songhui , Li Wei , Wen Dongdong , Luo Shi 
Published: January 2022

Abstract
In order to enhance the grinding performance of alumina ceramic materials, the surface of the grinding wheels are ablated by laser radiation before grinding, and the three types of leaf-vein bionic grinding wheels with different micro-groove pitches are formed to compare the grinding experiments with normal grinding wheels. The grinding forces and surface roughness were gauged and the morphological characteristics of ground workpiece surfaces were studied. The results showed that with the increase of groove pitch, the normal grinding force was reduced by 9.6-63%, while the tangential grinding force is reduced by 8.3-42%. The groove can promote the flow of coolant, accelerate the heat dissipation and chip removal in the grinding area, reduce the damage of the workpiece and the wear of the grinding wheel, so the vein bionic grinding wheel had more tremendous processing advantages. Among the four kinds of grinding wheels, the leaf-vein bionic grinding wheel with groove pitch equal to 8mm obtained the best grinding effect. The vein-shaped groove had a positive impact on the grinding process.
10 -Years Coronary Artery Disease Incidence and its Predictors in Overweight and Obese Adults Using A Competing Risk Model: A Longitudinal Study of Yazd Healthy Heart Cohort (YHHC)
Authors: Shahi‎ Mohsen Askari , Namayandeh Seyedeh Mahdieh , Midbody Mahmood Emami , Majidpour Fatemeh 
Published: January 2022

Abstract
We applied competing risk model to identify the predictors for Coronary Artery Disease (CAD) among 866 overweight and obese participants aged 20-74 years using their registered medical records in the first and second phase of Healthy Heart Cohort (YHHC) conducted in Yazd. These participants were free of coronary heart disease in the first phase of study. CAD was considered as the primary event and all other noncardiac deaths were considered as a competing event. The cumulative incidence of any CAD at the 5-year and 10-year follow-ups was approximately 6.8% and 10.6%, respectively, and approximately 4.6% and 8.5%, respectively, for all other noncardiac deaths. In both cause-specific and Fine-Gray models of risk factor diabetes type II, hypertriglyceridemia, university level of education (reversely), uric acid, age, systolic blood pressure and female gender (reversely) were associated with the increase risk of CAD. In addition to other traditional cardio metabolic risk factor we found that uric acid increased the risk of CAD in overweight and obese adults. It seems that lifestyle modification can reduce the risk of CAD. Also, high level of education had a protective effect on the risk of CAD. Both cause-specific and fine-gray models predicted similarly 10-years of CAD. The use of competing risk models in the presence of competing events is emphasized when interpreting survival studies.
Brg1 Promotes Airway Mucus Hypersecretion via IL-13 and the JAK1/2-STAT6 Signaling Pathway in Asthma
Authors: Zou Wenjing , xu maozhu , Hu Jie , Yang Lili , Gen Gang , Fu Zhou , Luo Zhengxiu 
Published: January 2022

Abstract
Backgroud: The chromatin remodeling factor Brg1 (Brahma-related gene 1) is an important nuclear protein that promotes the transcriptional activation or inhibition of target genes by regulating ATP hydrolysis to generate energy which rearranges the position of nucleosomes and the interaction of histone DNA. In this study, we explored the effect of Brg1 on airway mucus hypersecretion in asthma.Methods: Six-to-eight-week-old female wild-type C57BL/6 mice (wild-type, WT) and type II alveolar epithelial cells (AECIIs) specifically knockout Brg1 mice (Brg1fl/fl) were selected as the experimental subjects. The asthma group was established with house dust mite (HDM), and the control group was treated with normal saline (n=10). Wright's staining was used to detect inflammatory cells in bronchoalveolar lavage fluid (BALF). Invasive lung function was used to assess the airway compliance. Hematoxylin and eosin and periodic acid-schiff staining were used to detect mucus secretion. The virus was used to knock down the Brg1 gene in the bronchial epithelial cell line (16HBE) and stimulated with HDM. Immunohistochemistry was used to measure mucin glycoprotein 5AC (MUC5AC) protein expression in the airway epithelium and 16HBE cells. Western blotting was used to detect the expression of the MUC5AC and JAK1/2-STAT6 signaling pathways in mouse lung tissue and 16HBE. Co-immunoprecipitation (Co-IP) and Chromatin Immunoprecipitation (CHIP) were used to detect whether Brg1 could regulate the JAK1/2-STAT6 signaling pathway.Results: Specifically, knocking out the Brg1 gene in AECIIs can reduce airway inflammation, airway compliance, and mucus hypersecretion in asthma. Knockdown of the Brg1 gene can simultaneously reduce Interleukin-13 (IL-13) and the expression of MUC5AC protein in airway epithelial cells and the activation of the JAK1/2-STAT6 signaling pathway. The results of Co-IP and CHIP showed that Brg1 could bind to the JAK1/2 promoter region, regulating the activity of the JAK1/2-STAT6 pathway affects airway mucus secretion in asthma.Conclusion: Brg1 gene knockout in airway epithelial cells can reduce asthmatic airway mucus hypersecretion and the expression of MUC5AC protein in airway epithelial cells partly by inhibiting the activation of the JAK1/2-STAT6 signaling pathway.
Nano Zinc-Oxide Enhanced Photosynthetic Apparatus and Photosystem Efficiency of Maize (Zea Mays L.) in Sandy-Acidic Soils
Authors: Ahmad Wiqar , Nepal Jaya , Xin Xiaoping , He Zhenli 
Published: January 2022

Abstract
Conventional Zinc (Zn) fertilization (e.g., zinc sulfate) often leads to poor availability in soils. Zinc oxide nanoparticles (nano ZnO) can be a potential solution, but their effect on crop photosynthetic activity isn’t well documented. The effects of nano ZnO (50, 100, 150, 200 mg L-1) and application methods (seed-coating, soil-drench, and foliar-spray) in comparison with ZnSO4 recommended dose were evaluated for plant height, biomass, chlorophyll pigments and photosystem efficiency in a greenhouse pot experiment. 100 mg L-1 of nano ZnO significantly increased the chlorophyll (Chl.) a, b, a+b, carotenoids (x+c), a+b/x+c, SPAD, leaf Chl., total chlorophyll content plant-1, plant height and total biological yield (by 18-30%, 33-67%, 22-38%, 14-21%, 14-27%, 12-19%, 12-23% 58-99%, 6-11% and 16-20%, respectively) and reduced Chl. a/b (by 6-22%) over the other treatments (p<0.01) irrespective of application methods. Nano ZnO applied at 100 mg L-1 significantly increased photochemical quenching (qP) and efficiency of photosystem II (EPSII) compared to 150 and 200 mg L-1 regardless of application methods. The positive correlations between Chl. a and Chl. b (r2 0.90), Chl. a+b and x+c (r2=0.71), SPAD and Chl. a (r2=0.90), SPAD and Chl. b (r2=0.94) and SPAD and Chl. a+b (r2=0.93) indicates a uniform enhancement in chlorophyll pigments; SPAD value, qP, EPSII, and growth and yield parameters. This elucidates that the application of nano ZnO at 100 mg L-1 promotes corn biochemical health and photosynthesis, irrespective of the application method. These findings have a great propounding for improving plant growth through nano ZnO bio-fortification in acidic Spodosols.
Family Legacy: Depicting Diversity-Elevation Relationships of Tropical Tree Communities
Authors: Kamimura Vitor de Andrade , Marcusso Gabriel Mendes , Sabino Gabriel Pavan , Assis Marco Antonio , Joly Carlos Alfredo , Loiola Priscila de Paula 
Published: January 2022

Abstract

Unveiling the ecological processes driving diversity and its relationship to the environment remains a central goal in ecological studies. Here, we investigated the elevation effect on plant diversity patterns of tropical rainforests, using beta-, phylogenetic and alpha diversities. To do so, we compiled a forest dataset with 22,236 trees (DBH ≥ 4.8 cm) from 17 plots of 1 ha each along an elevational gradient (0 – 1,200 m a.s.l) in the Atlantic Forest of Southeastern Brazil. We found high phylogenetic and species rates of turnover – beta-diversity - along the elevational gradient. Alpha phylodiversity showed a monotonic decrease with increasing elevation, including or not fern species (a distantly related clade usually ignored in tropical ecology studies), while the phylogenetic structure was highly affected by the inclusion of fern trees. Species diversity showed a unimodal pattern for the whole community, and different patterns for the richest families. The diversity pattern of the whole community emerges from differences among species distribution of the richest families, while phylogenetic diversity seems to be gradually filtered by elevation. At intermediate elevations, higher species diversification within families might have led to different strategies and cooccurrence in tropical rainforests. We also showed that intricate effects of elevation in species assemblages can be better assessed using both ecological and evolutionary approaches, stressing the importance of species selection in diversity analyzes. Finally, we demonstrate that elevation has different effects on the species distributions of the richest families and warn that these differences should be considered in conservation planning.
Resveratrol Alleviates Oxidative Stress Induced by Oxidized Soybean Oils and Improves Gut Function via Changing Gut Microbiota in Weaned Piglets
Authors: Gao Yanan , Meng Qingwei , Song Xin , Zhao Qianqian , Shi Baoming 
Published: January 2022

Abstract
Background: The objective of this study was to investigate the effects of dietary resveratrol supplementation on growth performance, redox status, inflammatory state, and intestinal function of weaned piglets fed oxidized soybean oils.Methods: A total of twenty-eight castrated weaned male piglets with a similar body weight of 10.19 ±1 kg were randomly assigned to 4 dietary treatments for 28 days feeding trial with 7 replications per treatment and 1 piglet per replicate. Treatments were arranged as a 2×2 factorial with oil type [fresh soybean oils (FSOs) vs. oxidized soybean oils (OSOs)] and dietary resveratrol (RES) (0 vs. 300 mg/kg).Result: Inclusion of OSOs decreased the villus/crypt ratio (VCR), while the villus height (VH) and VCR in the jejunum of weaned piglets was increased by dietary RES (P< 0.05). The activities of lipase, chymotrypsin, and lactase were decreased by OSOs, however dietary RES supplementation increased the activities of lipase, chymotrypsin, lactase, and α-amylase in the jejunum of weaned piglets (P< 0.05). Dietary RES increased the apparent digestibility of crude fat (EE). Dietary RES supplementation in the diets supplemented with OSOs decreased the level of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) in the plasma of weaned piglets, but failed to influence the IL-1β, IL-6, IL-8, and TNF-α level when diets supplemented with FSOs. Dietary RES alleviated the decrease of total-superoxide dismutase activity in the plasma of weaned piglets fed OSOs (P< 0.05). Dietary supplemented with OSOs and RES decreased the level of H2O2 in the plasma of weaned piglets (P< 0.05). RES alleviates the intestinal barrier damage fed OSOs in weaned piglets by increasing the mRNA expression of ZO-1 and Occludin. It is noteworthy that inclusion of OSOs in diets increased the abundance of Actinobacteria, and decreased the abundance of Tenercutes (P< 0.05). RES increased the abundance of Firmicutes, and decreased the abundance of Bacteroidetes (P< 0.05). At the genus level, RES decreased the abundance of Prevotella-1, Prevotellaceae UCG003, and Clostridium_sensu_stricto_6 in the colon. OSOs decreased the level of acetic acid, and dietary RES increased the level of acetic acid and butyric acid in the colon of weaned piglets.Conclusions: Dietary RES supplementation improved the villus-crypt structure, digestive enzyme activities and alleviated OSOs induced digestive absorption disorder. In addition, RES may alleviate OSOs immune status and energy metabolism of weaned piglets by affecting gut microbiota and its metabolite SCFAs. Notably, this positive effect of RES on OSOs may be related to decrease in the abundance of Prevotella_1 and Prevotellaceae_UCG-003.
WITHDRAWN: Prediction of Osteoporosis Through Deep Learning Algorithms on Panoramic Radiographs
Authors: Tassoker Melek , Ozic Muhammet Usame , Yuce Fatma 
Published: January 2022

Abstract
Objective: The aim of the present study was to predict osteoporosis on panoramic radiographs of women over 50 years of age through deep learning algorithms.Method: Panoramic radiographs of 744 female patients over 50 years of age were labeled as C1, C2, and C3 depending on mandibular cortical index (MCI). According to this index; C1: presence of a smooth and sharp mandibular cortex (normal); C2: resorption cavities at endosteal margin and 1 to 3-layer stratification (osteopenia); C3: completely porotic cortex (osteoporosis). The data of the present study were reviewed in different categories including C1-C2-C3, C1-C2, C1-C3 and C1-(C2+C3) as two-class and three-class prediction. The data were separated as 20% random test data; and the remaining data were used for training and validation with 5-fold cross-validation. AlexNET, GoogleNET, ResNET-50, SqueezeNET, and ShuffleNET deep learning models are trained through the transfer learning method. The results were evaluated by performance criteria including accuracy, sensitivity, specificity, F1-score, AUC and training duration. Findings: The dataset C1-C2-C3 has an accuracy rate of 81.14% with AlexNET; the dataset C1-C2 has an accuracy rate of 88.94% with GoogleNET; the dataset C1-C3 has an accuracy rate of 98.56% with AlexNET; and the dataset C1-(C2+C3) has an accuracy rate of 92.79% with GoogleNET. Conclusion: The highest accuracy was obtained in differentiation of C3 and C1 where osseous structure characteristics change significantly. Since the C2 score represent the intermediate stage (osteopenia), structural characteristics of the bone present behaviors closer to C1 and C3 scores. Therefore, the data set including the C2 score provided relatively lower accuracy results.