bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local production of reactive oxygen species drives vincristine-induced axon degeneration
Authors: Gomez-Deza Jorge , Slavutsky Anastasia , Nebiyou Matthew , Pichon Claire Le 
Published: December 2022

Abstract

Neurological side effects arising from chemotherapy, such as severe pain and cognitive impairment, are a major concern for cancer patients. These major side effects can lead to reduction or termination of chemotherapy medication in patients, negatively impacting their prognoses. With cancer survival rates improving dramatically, addressing side effects of cancer treatment has become pressing. Here, we use iPSC-derived human neurons to investigate the molecular mechanisms that lead to neurotoxicity induced by vincristine, a common chemotherapeutic used to treat solid tumors. Our results uncover a novel mechanism by which vincristine causes a local increase in mitochondrial proteins that produce reactive oxygen species (ROS) in the axon. Vincristine triggers a cascade of axon pathology, causing mitochondrial dysfunction that leads to elevated axonal ROS levels and SARM1-dependent axon degeneration. Importantly, we show that the neurotoxic effect of increased axonal ROS can be mitigated by the small molecule mdivi-1 and antioxidants glutathione and mitoquinone, identifying a novel therapeutic avenue to treat the neurological effects of chemotherapy.
The role of green ICT on ecological footprint: Does environmental regulation work?
Authors: Lee Chien-Chiang , Chen Mei-Ping , Wu Wenmin 
Published: December 2022

Abstract
Using 95 countries’ panel data for the period 2000–2017, this research explores how GICT affects six types of ecological footprint (EF) with ERs as the interaction variables by concurrently testing the GICT-induced environmental Kuznets curve (EKC) hypothesis. Using a quantile regression (QR) that tests the effects of GICT on environment degradation varying across diverse quantiles of EF, we present the vital role that GICT plays in lessening cropland, forest area, and grazing land, while increasing consumption of built-up land. Additionally, the findings partially confirm the existence of an inverted U-shape EKC hypothesis of technologies about mitigation against climate change for cropland, forest area, and grazing land via consideration of non-market-based ER as the interaction term. GICT does not notably reduce carbon-absorption land usage, however, the interaction between GICT and non-market-based ER does.
Effect of glutamine on the systemic innate immune response in broiler chickens challenged with Salmonella pullorum
Authors: Wu Qiu jue , Zhu Long , Zhang Rong kai , Xing Zhong , Wang Cong , Liao Jia hui , Hu Nai zhi , Cheng Bin yao , Ma Yan , Wang Yu qin 
Published: December 2022

Abstract
Conclusion: These results indicate that Gln might stimulate the systemic innate immune responses of the spleen in broiler chickens challenged with S. pullorum.
Background: The effects of glutamine on the growth performance and systemic innate immune response in broiler chickens challenged with Salmonella pullorum were evaluated. A total of 600 one-day-old Arbor Acres broiler chickens were assigned randomly to 6 dietary treatments with 10 replicates for a 21-day feeding experiment. The experimental treatments were as follows: the control treatment (birds fed the basal diet), the Gln1 treatment, and the Gln 2 treatment (birds fed the basal diet supplemented with 0.5%, and 1.0% Glutamine, respectively). At 3 d of age, birds from each treatment were then oral gavage with 2.0 × 104 CFU/mL of S. pullorum suspension (1.0 mL per bird) or an equivalent amount of sterile saline alone, which served as a control.
Results: The results showed that S. pullorum infection had adverse effects on the average daily feed intake, average daily gain, and feed conversion ratio of broiler chickens compared with those of the CON treatment on d 7, decreased the spleen and bursa of Fabricius relative weights (except on d 21), serum immunoglobulin A (IgA),immunoglobulin G (IgG), and immunoglobulin M (IgM) concentrations, and spleen melanoma differentiation-associated gene 5 (MDA5) and laboratory of genetics and physiology gene 2 (LGP2) mRNA expression levels, and increased the mRNA expression levels of spleen Nodinitib-1 (NOD1), Toll-like receptors 2,4 (TLR2, TLR4), DNA-dependent activator of IFN-regulatory factors (DAI), mitochondrial antiviral-signaling protein (MAVS), P50, P65, and RelB on d 4, 7, 14, and 21.
Supplementation with Gln improved the relative weights of the spleen and bursa of Fabricius (except on d 21), increased the serum IgA, IgG, and IgM concentrations and the mRNA expression levels of spleen MDA5 and LGP2, and decreased the mRNA expression levels of spleen NOD1, TLR2, TLR4, DAI, MAVS, P50, P65, and RelB of S. pullorum-challenged broiler chickens.
Comparison of Mulligan Mobilization Technique Versus Mckenzie Exercises Among Patient With Sacroilliac Joint Dysfunction: a Randomized Clinical Trial
Authors: Ghafoor Faisal , Ahmad Zunaira , Soomro Mahjabeen , khan Wajid Javed , Pando Alejandro , Shafaqat Amina 
Published: December 2022

AbstractBackground:Sacroiliac joint dysfunction frequently causes pain in low back. Localized tenderness and pain around the sacroiliac joint are signs of sacroiliac joint dysfunction, which is made worse by strenuous activities.Objective:This study aimed to compare the effectiveness of mulligan mobilization Technique Versus McKenzie exercises among patients with sacroiliac joint Dysfunction.Methodology:Total 58 patients, with sacroiliac joint dysfunction were included who were fulfilled the eligibility criteria.This trial was registered withRegistration number: NCT05404451 Dated 01-08-2022.This study is assessor blind. We have used the convenient sampling technique and the Lottery Method was used to randomly select a participant who met the criteria for participation, and participants were then divided into the two groups at random. The researcher and participants were not informed of the allocation process. A research assistant who was unrelated to the next stage of the study covered up the allocation method. In envelopes, the allocation was concealed. The study subjects were categorized into two groups. Group A received treatment with mulligan mobilization technique while group B received treatment with McKenzie exercises. Both groups received treatment for four weeks. Using the VAS and the MODI scale, pain and disability were evaluated before and after treatment.Results:Results indicated that individuals of both therapy group mulligan and McKenzie showed improvement in VAS and MODI ratings P value was (>0.005). Additionally, it was observed that McKenzie exercises were more effective than Mulligan mobilization techniques at reducing pain, disability, and enhancing sitting, standing, and walking in patients P value was (>0.005). While there was no significant difference has been observed in personal care lifting, sleeping, when comparing both groups P value was (>0.005).Conclusion:This study concluded that Mulligan's Mobilization and McKenzie exercises are both beneficial in reducing pain and improving disability. The McKenzie exercises, however, are more efficient than Mulligan's Mobilization technique when the two groups are compared (at reducing pain, disability, and enhancing sitting, standing, and walking in patients).Trial Registration number: NCT05404451 Dated 03-06-2022
Inherent Spatiotemporal Uncertainty of Renewable Power in China
Authors: Wang Jianxiao , Chen Liudong , Tan Zhenfei , Du Ershun , Liu Nian , Ma Jing , Sun Mingyang , Li Canbing , Song Jie , Lu Xi , Tan Chin-Woo , He Guannan 
Published: December 2022

Abstract
Solar and wind resources are vital for the sustainable and cleaner transition of the energy supply. Although renewable energy potentials are assessed in the literature, few studies examine the statistical characteristics of the inherent uncertainties of renewable generation arising from natural randomness, which is inevitable in stochastic-aware research and applications. Here we develop a rule-of-thumb statistical learning model for wind and solar power prediction and generate an hourly and year-long dataset of prediction errors in 30 provinces of China. The results reveal diversified spatial and temporal distribution patterns of prediction errors, indicating that more than 70% of wind prediction errors and 50% of solar prediction errors arise from scenarios with high utilization rates. We discover that the first-order difference and peak ratio of generation series are two primary indicators explaining the distribution characteristics of prediction errors. Furthermore, the prediction errors could result in additional CO2 emissions from coal-fired thermal plants. We estimate that such emission would potentially reach 319.7 megatons in 2030, accounting for 7.7% of China’s power sector. Finally, improvements in investment incentives and interprovincial scheduling could be suggested.
Versatile optical manipulation of trions, dark excitons and biexcitons through contrasting exciton-photon coupling
Authors: Li Zhe , Zhang Xin-Yuan , Ma Rundong , Fu Tong , Zeng Yan , Cheng Yufeng , Wang Cheng , Wang Yun , Feng Yuhua , Taniguchi Takashi , Watanabe Kenji , Wang Ti , Liu Xiaoze , Xu Hongxing 
Published: December 2022

Abstract
Various exciton species in transition metal dichalcogenides (TMDs), such as neutral excitons, trions (charged excitons), dark excitons, and biexcitons, have been individually discovered with distinct light-matter interactions. In terms of valley-spin locked band structures and electron-hole configurations, these exciton species demonstrate flexible control of emission light with degrees of freedoms (DOFs) such as intensity, polarization, frequency and dynamics. However, it remains elusive to fully manipulate different exciton species on demand for practical applications. Here, we investigate the contrasting light-matter interactions to control multiple DOFs of emission light in a hybrid monolayer WSe2-Ag nanowire (NW) structure by taking advantages of various exciton species. These excitons, including trions, dark excitons and biexcitons, are found to couple independently with propagating surface plasmon polaritons (SPPs) of Ag NW in quite different ways, thanks to the orientations of transition dipoles. Consistent with the simulations, the dark excitons and dark trions show extremely high coupling efficiency with SPPs, while the trions demonstrate directional chiral-coupling features. This study presents a crucial step towards the ultimate goal of exploiting the comprehensive spectrum of TMD excitons for optical information processing and quantum optics.
Ocular surface involvement and histopathologic changes in the acute stage of Stevens- Johnson Syndrome and Toxic Epidermal Necrolysis: a cross-sectional study
Authors: Liu Yingyi , Feng Jianing , Ren Yuerong , Shi Wen , Kang Huanmin , Peng Yingqian , Tan Yixin , Wu Ruifang , Zhang Guiying , He Yan 
Published: December 2022

Abstract
Background
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and extremely serious drug-induced dermatological disorders. The ocular surface condition at the early stage has been little studied and should contribute to novel perspectives in early and effective topical therapy of these diseases. The objectives of the study were to evaluate the acute phase of ocular surface involvement and histopathologic changes in patients with acute SJS/TEN.
Methods
Ten patients with acute phase of SJS/TEN onset and eleven age- and sex-matched healthy volunteers were recruited. Ocular surface symptoms and signs, conjunctival impression cytology, and tear multi-cytokine were assessed.
Results
Ocular surface objective signs were normal at the acute stage of SJS/TEN, while most patients have abnormal ocular surface subjective symptoms and meibomian gland secretion. Conjunctival impression cytology showed a significant decrease in goblet cell density and severe ocular surface squamous metaplasia in acute SJS/TEN patients. Tear multi-cytokine analysis showed all 21 pro- and anti-inflammatory cytokines all sharply elevated.
Conclusions
Severe pathologic squamous metaplasia and inflammation onset in the ocular surface at the acute stage of the SJS/TEN, even if the ocular surface condition seemed basically normal with adequate systemic immunosuppressant and general supportive treatment. Early topical anti-inflammatory therapy should be carried out actively.
Single-cell molecular profiling using ex vivo functional readouts fuels precision oncology in glioblastoma
Authors: Panovska Dena , Nazari Pouya , Cole Basiel , Creemers Pieter-Jan , Derweduwe Marleen , Solie Lien , Gassen Sofie Van , Claeys Annelies , Verbeke Tatjana , Saeys Yvan , Plancken David Van Der , Bosisio Francesca M. , Put Eric , Bamps Sven , Clement Paul M. , Verfaillie Michiel , Sciot Raf , Ligon Keith L. , De Vleeschouwer Steven , Antoranz Asier , De Smet Frederik 
Published: December 2022

Abstract
Background

Functional profiling of freshly isolated glioblastoma cells is being evaluated as a next-generation method for precision oncology. While promising, its success largely depends on the method to evaluate treatment activity which requires sufficient resolution and specificity.

Methods

Here, we describe the ‘precision oncology by single-cell profiling using ex vivoreadouts of functionality’ (PROSPERO) assay to evaluate the intrinsic susceptibility of highgrade brain tumor cells to respond to therapy. Different from other assays, PROSPERO extends beyond life/death screening by rapidly evaluating acute molecular drug responses at single-cell resolution.

Results

The PROSPERO assay was developed by correlating short-term single-cell molecular signatures using CyTOF to long-term cytotoxicity readouts in representative patientderived glioblastoma cell cultures (n=14) that were exposed to radiotherapy and the smallmolecule p53/MDM2 inhibitor AMG232. The predictive model was subsequently projected to evaluate drug activity in freshly resected GBM samples from patients (n=34). Here, PROSPERO revealed an overall limited capacity of tumor cells to respond to therapy, as reflected by the inability to induce key molecular markers upon ex vivo treatment exposure, while retaining proliferative capacity, insights that were validated in PDX models. This approach also allowed the investigation of cellular plasticity, which in PDCLs highlighted therapy-induced proneural-to-mesenchymal transitions, while in patients’ samples this was more heterogeneous.

Conclusion

PROSPERO provides a precise way to evaluate therapy efficacy by measuring molecular drug responses using specific biomarker changes in freshly resected brain tumor samples, in addition to providing key functional insights in cellular behavior, which may ultimately complement standard, clinical biomarker evaluations.
Malaria drives unique regulatory responses across multiple immune cell subsets
Authors: Dooley Nicholas , Chabikwa Tinashe , Pava Zuleima , Loughland Jessica , Hamelink Julianne , Berry Kiana , Andrew Dean , Soon Megan , SheelaNair Arya , Piera Kim , William Timothy , Barber Bridget , Grigg Matthew , Engwerda Christian , López J. Alejandro , Anstey Nicholas , Boyle Michelle 
Published: December 2022

Abstract
Plasmodium falciparum malaria results in immunoregulatory responses across multiple cell subsets, which protects the individual from inflammatory mediated immunopathogenesis. However, these anti-inflammatory responses also hamper the development of effective anti-parasitic immunity. Understanding malaria induced tolerogenic responses in specific cell subsets may inform the development of strategies to boost protective immunity during drug treatment and vaccination. Here, we analysed the immune landscape with single cell RNA sequencing of peripheral blood mononuclear cells during falciparum malaria and at convalescence in children and adults from a low malaria transmission area in Malaysia. To understand malaria driven changes specific to each immune cell subset, we interrogated transcriptional changes in sub-clustered major immune cell types during infection. We found that malaria drove development of immunosuppressive monocytes, alongside NK and γδ T cells which regulated inflammatory function but maintained cytolytic capacity. IL10-producing CD4 T cells and IL10-producing regulatory B cells were also induced. Type I interferon responses were identified across all cell types, linking Type I interferon signalling with the induction of immunoregulatory networks during malaria. Together, these findings provide insights into cell-specific and shared immunoregulatory changes induced during malaria, and provides a data set resource for additional analysis of anti-parasitic immunity and disease pathogenesis.
Experimental investigation on the mechanical properties and large laboratory test of a novel filling material in mining engineering
Authors: Hong Zi-jie , Li Zhen-hua , Du Feng , Xu Lei , Zhu Chun 
Published: December 2022

Abstract
In this paper, a novel filling material was developed which consisted of coal gangue and fly ash mixture as the main material, the ground slag, quicklime and plaster mixture as the cementing material. Moreover, an auxiliary agent was added as an activator. Test results showed that the optimum composition of the filling material was: 2:1 ratio of coal gangue and fly ash, which accounted for 85% of the total mass; 5:3:2 ratio of ground slag(G)-quicklime(Q)-plaster(P), which accounted for 15% of the total mass; expansive agent content of 0.01% and modifier additive content of 1.0%. A large volume sample (1m*1m*1m) was tested with this optimized material composition. The experimental temperature, mechanical performance, regeneration strength, and failure characteristics were determined. The results showed that the temperature of the middle part of the filling body was the highest and reached the peak of 40.2℃. The filling material had high compressive strength, and presented ideal plastic deformation characteristics. The strength could be restored after the damage had occurred and the fracture surface along a certain angle was destroyed.
Entanglement dynamics in the spin-1/2 XX chain with uniform Dzyaloshinskii-Moriya interaction revisited
Authors: Motamedifar Mostafa , Sadeghi Fatemeh , Golshani Mojatab 
Published: December 2022

Abstract
We revisited the effectiveness of state and entanglement transmission through a spin-chain-based quantum channel while altering the system parameters and the channel’s initial state. Our research is focused on the spin-1/2 XX chain with Dzyaloshinski-Moriya (DM) interaction and the aim is to measure entanglement dynamics between different part of the chain. The speed of entanglement propagation is utilized to probe the evolution of the system via three scenarios: (i) pure Heisenberg interaction, (ii) pure DM interaction, and (iii) collaboration of both types of couplings. To accomplish this, we employ the fermionization approach to obtain an exact solution to the problem. Aside from investigating the influence of magnetic interaction type on entanglement transfer, the effect of selecting the initial state has also been studied. As a result, we discovered that the phase factor (φ) regulating the system’s initial state induces sharp drops in the propagation speed of entanglement. In addition, the fastest transmission occurs at a special value of φ in which the highest amount of entanglement reaches the system’s different pairs. On the other hand, we observe a continuous and flat range of φ in which the least amount of entanglement is transmitted and for them we have a sharp drop in the speed profile.
Active Suspension Control Strategy for Vehicles Based on Road Surface Recognition
Authors: Yang Taiping , Li Peiqing , Li Qipeng , Li Zhuoran 
Published: December 2022

Abstract

An adaptive model predictive control (AMPC) algorithm based on pavement identification was proposed to determine the influence of different pavement inputs on a vehicle suspension system. First, a vehicle dynamics model was established, and a discrete leveling index-based pavement comfort assessment method was proposed based on the international leveling index to quantify the comfort level by calculating the maximum instantaneous vibration index based on the vertical acceleration of the driver's seat. Second, an augmented Kalman filter algorithm with a forgetting factor is proposed to track the pavement time-varying parameters and estimate pavement leveling. Finally, the control of the quarter-vehicle active suspension system is transformed into solving the decay of hard constraints, designing the AMPC strategy, parameterizing the cost function of AMPC with the global cost of the performance index as the evaluation function, and using Bayesian optimization to predict the time domain and weight of the cost function to achieve the global performance optimum. While satisfying the dynamic constraints, passenger comfort is improved by attenuating roadway pre-sighting disturbances. Experimental results indicate that the proposed active suspension AMPC algorithm improves suspension smoothness and driver comfort compared with the MPC algorithm and passive suspension. The effectiveness of the proposed control algorithm for different road vibrations was verified.
Comparison of Age and Modified Frailty Index-5 as Predictors of In-Hospital Mortality in Complete Traumatic Cervical Spinal Cord Injury
Authors: Shakil Husain , Jaja Blessing N.R. , Zhang Peng F. , Jaffe Rachael H. , Malhotra Armaan K. , Harrington Erin M. , Wilson Jefferson R. , Witiw Christopher D. 
Published: December 2022

Abstract
Frailty, as measured by the modified frailty index-5 (mFI-5), and older age are associated with increased mortality in the setting of spinal cord injury (SCI). However, a comparison of the predictive power of each measure has not been completed. We conducted a retrospective cohort study to evaluate in-hospital mortality among adult complete cervical SCI patients at participating centers of the Trauma Quality Improvement Program from 2010 to 2018. Logistic regression was used to predict in-hospital mortality, and the area under the Receiver Operating Characteristic curve (AUROC) of regression models with age, mFI-5, or age with mFI-5 was used to compare predictive power. 4,733 patients were eligible. We found significant effect of age > 75 years (OR 9.77 95% CI [7.21 13.29]) and mFI-5 ≥ 2 (OR 3.09 95% CI [1.85 4.99]) on in-hospital mortality. The AUROC of a model including age and mFI-5 (0.81 95%CI [0.79 0.84] AUROC) was comparable to a model with age alone (0.81 95%CI [0.79 0.83] AUROC). Both models were superior to a model with mFI-5 alone (0.75 95% CI [0.72 0.77] AUROC)). Our findings suggest that age provides more predictive power than mFI-5 in the prediction of in-hospital mortality for complete cervical SCI.