bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression Symptoms and Olfactory‐related Quality of Life
Authors: Liu David T. , Prem Bernhard , Sharma Gunjan , Kaiser Julia , Besser Gerold , Mueller Christian A. 
Published: March 2022

ObjectivesPatients with olfactory dysfunction (OD) frequently report symptoms of depression. The objective of this study was to determine how clinical characteristics and olfactory‐related quality of life (QoL) measures associate with the likelihood for major depressive disorders (MDDs).MethodsA total of 192 OD patients were included. Olfactory function was measured using all three subtests of the Sniffn' Sticks test. Olfactory‐related quality of life (QoL) was evaluated using the Questionnaires of Olfactory Dysfunction (QOD)‐negative (NS) and ‐positive statement (PS). The likelihood for MDD was assessed using the Patients Health Questionnaire‐2 (PHQ‐2). Demographics and disease‐specific variables (etiology and duration of OD) were collected. Univariate and multivariable analyses were used to associate disease‐specific variables and the QOD with the outcome of the PHQ‐2. Additionally, the predictive ability of the QOD‐NS to predict depressive symptoms was calculated.ResultsIn univariate analysis, COVID‐19 related smell loss, the QOD‐NS, and the QOD‐PS were significantly associated with the PHQ‐2. In multivariable analyses adjusting for QoL measures, the QOD‐NS (ß = 0.532, p < 0.001) and sinonasal OD (compared with postinfectious OD) were significantly associated with the PHQ‐2 (ß = 0.146, p = 0.047). When omitting QoL measures from multivariable analyses, only COVID‐19 related OD (compared with postinfectious OD) was significantly associated with the PHQ‐2 (ß = 0.287, p = 0.009). A QOD‐NS score > 20.5 had 70.13% sensitivity and 76.32% specificity for detecting symptoms of depression.ConclusionOur results suggest that COVID‐19 related OD might be associated with a higher likelihood for MDD. Furthermore, we showed that the QOD‐NS score might be helpful to predict symptoms of depression in OD patients.Level of Evidence4 Laryngoscope, 132:1829–1834, 2022
Better together: Integrating biomedical informatics and healthcare IT operations to create a learning health system during the COVID‐19 pandemic
Authors: Payne Philip R.O. , Wilcox Adam B. , Embi Peter J. , Longhurst Christopher A. 
Published: March 2022

AbstractThe growing availability of multi‐scale biomedical data sources that can be used to enable research and improve healthcare delivery has brought about what can be described as a healthcare “data age.” This new era is defined by the explosive growth in bio‐molecular, clinical, and population‐level data that can be readily accessed by researchers, clinicians, and decision‐makers, and utilized for systems‐level approaches to hypothesis generation and testing as well as operational decision‐making. However, taking full advantage of these unprecedented opportunities presents an opportunity to revisit the alignment between traditionally academic biomedical informatics (BMI) and operational healthcare information technology (HIT) personnel and activities in academic health systems. While the history of the academic field of BMI includes active engagement in the delivery of operational HIT platforms, in many contemporary settings these efforts have grown distinct. Recent experiences during the COVID‐19 pandemic have demonstrated greater coordination of BMI and HIT activities that have allowed organizations to respond to pandemic‐related changes more effectively, with demonstrable and positive impact as a result. In this position paper, we discuss the challenges and opportunities associated with driving alignment between BMI and HIT, as viewed from the perspective of a learning healthcare system. In doing so, we hope to illustrate the benefits of coordination between BMI and HIT in terms of the quality, safety, and outcomes of care provided to patients and populations, demonstrating that these two groups can be “better together.”
Prevalence of DSM‐5 somatic symptom disorder in Chinese patients with breast cancer
Authors: Li Jinjiang , Fritzsche Kurt , Glinka Mark , Pang Ying , Song Lili , Wang Yan , Li Zimeng , He Yi , Zhang Yening , He Shuangzhi , Leonhart Rainer , Toussaint Anne‐Kristin , Tang Lili 
Published: March 2022

AbstractObjectiveThe aims of this study were to explore the frequency of somatic symptom disorder (SSD) and the relationship between SSD and somatic, psychological, and social factors in Chinese patients with breast cancer.MethodsThis multicenter cross‐sectional study enrolled 264 patients with breast cancer from three different departments in Beijing. The structured clinical interview for fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (SCID‐5) for SSD. Standardized questionnaires and clinical data were used to compare patients with and without SSD.ResultsSomatic symptom disorder was diagnosed in 21.6% (57/264) of all enrolled patients. No differences were found between SSD patients and non‐SSD patients in terms of sociodemographic characteristics and tumor‐specific variables, except radiotherapy. However, patients with SSD reported higher levels of depression, anxiety and cancer‐related worry. They also showed a longer duration of symptoms, greater impairment in daily life, more concern over their physical complaints and more doctor visits. In a stepwise binary logistic regression analysis, among others, higher health anxiety (WI‐8, Exp(B) = 0.107, p = 0.009) and more doctor visits (OR = −1.841, p < 0.001) showed a significant association with SSD; the model explained 53.7% of the variance.ConclusionsSimilar to other physical diseases, there is a high prevalence of SSD in patients with breast cancer. Somatic symptom disorder patients differ from non‐SSD patients by exhibiting higher cancer‐related emotional distress and dysfunctional illness perception and behavior. There remain substantial challenges in the diagnosis of SSD in patients with cancer and other medical conditions.Clinical Trial Registration: ChiCTR2100051525.
Unintended changes in transgenic maize cause no nontarget effects
Authors: Wang Yuanyuan , Liu Qingsong , Song Xinyuan , Yang Xiaowei , Han Lanzhi , Romeis Jörg , Li Yunhe 
Published: March 2022

Societal Impact StatementGenetic engineering is used to introduce new genes into plants to obtain crops with novel traits. However, the unintended effects of genetically engineered (GE) crops on nontarget organisms—such as beneficial insects—are a topic of much concern. We evaluate the potential unintended effects of pollen from three GE maize and seven commercialized conventional maize lines on the ladybird beetle Propylea japonica, by combining omics approaches with feeding assays. Our results suggest that unintended changes caused by genetic engineering in maize pollen may not lead to biologically relevant effects on P. japonica. Meanwhile our study provides a useful strategy to assess the biological impacts of genetic engineering on nontarget organisms.Summary

The potential effects caused by the inserted traits in genetically engineered (GE) plants on nontarget organisms (NTOs) have been well assessed. However, whether the process of genetic engineering itself causes unintended changes that go beyond the natural variation of the crop and further poses any biological effects to NTOs is still under debate.
Here, we evaluated the potential unintended effects of pollen from three GE maize and seven commercialized conventional maize lines on the NTO Propylea japonica by combining omics approaches with feeding assays.
The results showed that genetic breeding indeed brought somewhat differences at both proteome and metabolome levels in maize pollen, although such differences were far more common in conventionally crossbred plants. Feeding experiments indicated that the changes in proteins and metabolites caused by genetic breeding did not lead to unintended effects on the NTOs that go beyond those measured for the conventional crossbred lines.
Together, our results suggest that the differences detected by omics experiments may not cause any biological relevant effects on NTOs and the combination of omics approaches and NTOs feeding assays provide a valid approach to assess the biological relevance of compositional effects caused by genetic breeding.
A quantitative approach to the choice of number of samples for percentile estimation in bootstrap and visual predictive check analyses
Authors: Jonsson E. Niclas , Nyberg Joakim 
Published: March 2022

AbstractUnderstanding the uncertainty in parameter estimates or in derived secondary variables is important in all data analysis activities. In pharmacometrics, this is often done based on the standard errors from the variance–covariance matrix of the estimates. Confidence intervals derived in this way are by definition symmetrical, which may lead to implausible outcomes, and will require translation to generate uncertainties in derived variables. An often‐used alternative is numerical percentile estimation by, for example, nonparametric bootstraps to circumvent these issues. Visual predictive checks (VPCs), which is a commonly used model diagnostic tool in pharmacometric analyses, also rely on the estimation of percentiles through numerical approaches. Given the cost in terms of run times and processing times for these methods, it is important to consider the trade‐off between the number of bootstrap samples or simulated data sets in the VPCs, to the increase in precision related to a large number of bootstrap samples or simulated data sets. The objective with this tutorial is to provide a quantitative framework for assessing the precision in estimated percentile limits in bootstrap and visual predictive checks analyses to facilitate an informed choice of confidence interval width, number of bootstrap samples/simulated data sets, and required level of precision.
Customizing the microenvironment of CO2 electrocatalysis via three‐phase interface engineering
Authors: Zhou Xianlong , Liu Hao , Xia Bao Yu , Ostrikov Kostya (Ken) , Zheng Yao , Qiao Shi‐Zhang 
Published: March 2022

AbstractConverting CO2 into high‐value fuels and chemicals by renewable‐electricity‐powered electrochemical CO2 reduction reaction (CRR) is a viable approach toward carbon‐emissions‐neutral processes. Unlike the thermocatalytic hydrogenation of CO2 at the solid‐gas interface, the CRR takes place at the three‐phase gas/solid/liquid interface near the electrode surface in aqueous solution, which leads to major challenges including the limited mass diffusion of CO2 reactant, competitive hydrogen evolution reaction, and poor product selectivity. Here we critically examine the various methods of surface and interface engineering of the electrocatalysts to optimize the microenvironment for CRR, which can address the above issues. The effective modification strategies for the gas transport, electrolyte composition, controlling intermediate states, and catalyst engineering are discussed. The key emphasis is made on the diverse atomic‐precision modifications to increase the local CO2 concentration, lower the energy barriers for CO2 activation, decrease the H2O coverage, and stabilize intermediates to effectively control the catalytic activity and selectivity. The perspectives on the challenges and outlook for the future applications of three‐phase interface engineering for CRR and other gas‐involving electrocatalytic reactions conclude the article.
Thermoresistant Newcastle disease vaccine effectively protects SPF, native, and commercial chickens in challenge with virulent virus
Authors: Abdoshah Mohammad , Hassanzadeh Mohammad , Masoudi Shahin , Ashtari Abbas , Yousefi Ali Reza , Partovi Nasr Minoo 
Published: March 2022

AbstractBackgroundDue to the more stability and a better homogenecity in immune response, the use of thermoresistant vaccines in different chicken types has been increased.ObjectiveThis study aimed to evaluate the efficacy of a newly developed Newcastle disease vaccine (ND.TR.IR) originating from I‐2 strain in specific pathogen‐free (SPF) and native and broiler chickens.MethodsFollowing determination of pathogenicity indices on the candidate seed, three efficacy examinations were conducted. In the first experiment, 120 1‐day‐old SPF chickens were randomly allocated to six groups and either vaccinated with ND.TR.IR via eye drop at 1, 7, and 21 days of age (V1, V7, and V21), or considered as non‐vaccinated control groups (C1, C7, and C21). At 20th post‐vaccination day, sera hemagglutination inhibition (HI) antibody titres against ND virus (NDV) were measured and then the chickens were challenged by virulent NDV (vNDV). In the second and third experiments, the efficacy of ND.TR.IR vaccine was compared to routine vaccination program (B1 and LaSota) in native and broiler chickens that were vaccinated at 10 and 20 days of age, respectively. The HI antibody titres were measured on 10, 20, 30, and 40 days of age, and also challenge efficacy test with vNDV was conducted on 30 days of age.ResultsThe studied virus, as a vaccinal seed, complied with the pathogenicity indices of avirulent NDV and molecular identity of I‐2 strain. In the efficacy evaluation trials, the vaccinated chickens had higher HI antibody titres against NDV compared with their corresponding control chickens (p < 0.05). Results of the challenge tests indicated 95% and 100% protection against vNDV in native, SPF, and broiler‐vaccinated chickens, respectively.ConclusionsThe present findings indicated that administration of ND.TR.IR induced appropriate HI antibody titres against NDV in SPF, native, and broiler chickens associated with good protection in efficacy test.
The interaction between Environmental Enrichment and fluoxetine in inhibiting sucrose-seeking renewal in mice depend on social living condition
Authors: Pintori N. , Piva A. , Guardiani V. , Marzo C. M. , Decimo I. , Chiamulera C. 
Published: March 2022

Abstract
Rationale
Several single or combined therapeutic approaches have been developed to treat addiction, however with partial efficacy in preventing relapse. Recently, the living environment has been suggested as a critical intervening factor determining the treatment outcomes. Despite accumulating evidence confirming a role of living conditions in the vulnerability to addictive behaviours, their impact on single or integrative therapeutic strategies preventing relapse is yet to be identified.

Objectives
Here, we explore the possible interaction between brief Environmental Enrichment (EE) exposure and acute fluoxetine administration in inhibiting sucrose-seeking behaviours, and whether this effect could be affected by living environment.

Methods
Social and isolated adult male C57BL/6 mice were trained to sucrose self-administration associated to a specific conditioning context (CxA), followed by a 7-day extinction in a different context (CxB). Afterwards, mice were exposed for 22 h to EE and then injected with fluoxetine (10 mg/kg, i.p.) 1 h before a CxA-induced sucrose-seeking test.

Results
Brief EE exposure and acute fluoxetine administration alone inhibited context-induced sucrose-seeking in both housing conditions; however, they exhibited additive properties only in social condition.

Conclusions
Our data show that social environment may influence the EE/fluoxetine interaction in inhibiting relapse to sucrose. These findings suggest that setting up proper living conditions to boost the efficacy of therapeutic approaches may represent a fundamental strategy to treat addiction disorders.
Lower grade students tend to give up early in multimedia learning
Authors: Zhao Fang , Gaschler Robert , Wagner Inga , Schnotz Wolfgang 
Published: March 2022

Abstract
This study examined the relationship between grade and the ability of text-picture integration in terms of task completion and the pattern of using textual and pictorial information. Children (N = 144) from secondary schools were recruited from grade 5 and grade 8. Analyzing the time spent with the multimedia unit prior to an incorrect response, this study suggests that 5th graders tend to give up relatively early compared to 8th graders. Furthermore, early incorrect responses were more prevalent among students of the non-academic track and were predicted by a low proportion of fixations on the text in mental model construction and on the picture in adaptive mental model specification. An inappropriate approach of integrating text and picture can thus be the reason for giving up early. The work provides a basis for (1) automated feedback during the course of working on a multimedia unit. (2) Instructional design should be adapted to the characteristics of student groups to support text-picture integration and to avoid giving up early.
The challenges of a food sovereignty perspective: an analysis of the foodways of the Rama indigenous group, Nicaragua
Authors: Papworth Andrew , Maslin Mark , Randalls Samuel 
Published: March 2022

AbstractDespite its prominence within food security debates, Food Sovereignty is still a developing and contested concept. This article illustrates two of the tensions within the Food Sovereignty literature through an analysis of the foodways of the Rama indigenous group in Nicaragua. Firstly, the results show that there is considerable heterogeneity in how the Rama source their food and that, for most Rama, engagement with the market economy is critical to ensuring their own food security. This presents a further challenge to the idea that Food Sovereignty should only promote a one-size-fits-all “small-scale farming” approach to food security. Secondly, the paper shows there is considerable conflict over resources between the Rama and Pacific Nicaraguans who have encroached on their territory. This finding reinforces the view that Food Sovereignty needs to be further developed to be able to give clear direction in similar instances. This article concludes by arguing that although these tensions need to be resolved in order to boost the utility of Food Sovereignty on the ground, the concept can provide a useful theoretical arena in which to highlight the food security threats that are faced by communities like the Rama.
Powers and the hard problem of consciousness: conceivability, possibility and powers
Authors: Allen Sophie R 
Published: March 2022

AbstractDo conceivability arguments work against physicalism if properties are causal powers? By considering three different ways of understanding causal powers and the modality associated with them, I will argue that most, if not all, physicalist powers theorists should not be concerned about the conceivability argument because its conclusion that physicalism is false does not hold in their favoured ontology. I also defend specific powers theories against some recent objections to this strategy, arguing that the conception of properties as powerful blocks conceivability arguments unless a rather implausible form of emergence is true.
Carbon-based nanohybrid fabricated in-situ and boosted the adsorption of anionic reactive yellow dye
Authors: Fathy N. A. , El-Shafey S. 
Published: March 2022

AbstractThe purpose of this research is to report a unique manipulation of producing carbon nanotubes/carbon xerogel (CNTs/CX) hybrid loaded with bimetallic catalysts of Fe–Ni via one-step chemical vapor deposition (CVD) of camphor. Active bimetallic catalysts were formed during carbonization of resorcinol–formaldehyde xerogel at 800 °C to form carbon xerogel (CX); meanwhile, the carbon gas was librated from camphor at 220 °C for 45 min. CX and CNTs/CX samples were analyzed using measurements of transmission electron microscope (TEM), X-ray diffraction tool (XRD) and Fourier transform infrared spectroscopy (FTIR). Further, the liquid-phase adsorption of a reactive yellow 160 (RY160) dye on CX and CNTs/CX samples and thermodynamic studies were investigated. TEM and XRD results revealed the formation of carbon nodules in CX combined with bundles of CNTs having outer diameters ranged from 40 to 80 nm in CNTs/CX. Adsorption of RY160 dye was highly relied on pH, temperature, initial dye concentration and contact time. Through kinetic modeling, pseudo-second-order kinetic model expressed closely the experimental data of RY160 adsorption. Equilibrium adsorption studies declared that the Freundlich model is the better with adsorption of RY160 on CNTs/CX due to it has heterogeneous surface character resulting from combination of CX and CNTs. Langmuir adsorption capacity (qL, mg/g) values exhibited that CNTs/CX sample have a superior adsorption of RY160 dye which were reached to 167 mg/g than that by CX (qL = 125 mg/g). Thereof, the produced CX and CNTs/CX samples present higher removal capacity and can be employed successfully for RY160 dye removal from a textile wastewater.
Families Expecting and Living with a Baby: a Perspective on Parental Worries
Authors: Lepistö Sari , Raunima Mari , Paavilainen Eija 
Published: March 2022

AbstractThe aim is to describe parents’ worries about their family’s life situation during pregnancy and when their children are very young. The aim is to form a better understanding of parental worries for being able to better help them in child and family services. Previous research indicates that parental worries and concerns are not always addressed. Data consisted of parents’ open answers (N  = 98) to questionnaires carried out at two time points: during pregnancy and the early childhood of the family’s children. The data were analyzed by inductive content analysis. The results show that families had six different types of worries. The parents described worries concerning health, parental challenges, relationships, sufficiency of resources, standard of living, and difficulties in obtaining support. Challenges related to family life or parenthood could emerge suddenly or develop slowly and cumulate. Either kinds of challenges were often difficult to solve without outside assistance. Identifying and intervening in parental worries sufficiently early is crucial and effective. It is difficult for the professionals who work with families to form a comprehensive perception of children’s and family’s life situation without systematic evaluation and discussions on parental worries.
Curriculum considerations in music education in England: spiral thinking, spiral planning and its impact on contemporary thought
Authors: Fautley Martin , Daubney Alison 
Published: March 2022

AbstractThis article considers the impact that the Swanwick-Tillman spiral article (Swanwick & Tillman, 1986) has had on contemporary thinking in music education in England. Building on a discussion concerning the antecedents of the notion of a spiral, the ways in which a generalist music curriculum can be planned and organised are discussed. Drawing on the contemporary example of the Model Music Curriculum (DfE, 2021), and then charting this thinking as arising from a graded music examination repertoire-based way of planning, this article goes on to explain why the Swanwick-Tillman spiral still has relevance, as well as much to teach us in today’s very different music education world where assessment, measurement and accountability are dominant. Although centred on the situation in England, there are nonetheless implications for curriculum planners in many other jurisdictions too.
A new understanding of disability in international humanitarian law: Reinterpretation of Article 30 of Geneva Convention III
Authors: Palomino Priscilla Denisse Coria 
Published: March 2022

AbstractThis paper examines whether the interpretation of Article 30 of Geneva Convention III that allows the use of solitary confinement for prisoners of war with psychosocial disabilities is still valid in light of the new standards of the Convention on the Rights of Persons with Disabilities. It proposes two alternative interpretations of Article 30 to demonstrate why isolation based on disability is unlawful and concludes that the use of solitary confinement on prisoners of war with psychosocial disabilities should be prohibited.