bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study regarding Parental Knowledge, Attitude and Practice (KAP) among Antibiotic Use in Children in Henan Province of China
Authors: Ma Weifeng , Huang Chunzhi , Wang Cailian , Liu Qinglan , Zhao Qinghe , Ren Yanli 
Published: August 2022

Abstract
Aim
Inappropriate antibiotic use leads to AMR. This research targets to learn about Henan Province parental knowledge, attitude and practice regarding antibiotic use in their children.
Materials and methods
During the October through December 2020, Henan Maternal and Child Health Hospital's hospitalized parents participated in a cross-sectional questionnaire survey. The study was evaluated using logistic regression analysis.
Results
In general, parents were less knowledgeable about the following topics: antibacterial medications are not anti-inflammatory medications; scientists cannot always discover new drugs; colds and viral infections cannot be treated with antibacterial medications; and the combined effects of antibacterial medications are not always superior. The respective awareness rates were 40.83%, 28.37%, 57.09%, 39.10%, and 59.52%. For the attitude, a little of parents still had misconceptions. In total, 10.73% parents were willing to use antibiotics, 16.61% believed that expensive antibiotics would be more effective, 45.68% parents didn’t agree the doctor's treatment plan, 14.19% parents would be dissatisfied of no antibacterial drugs, 10.73% parents believed they understood antibiotics well, just only 57.79% parents were correct in their understanding of broad-spectrum antibiotics.
Conclusions
Parental knowledge of antimicrobial agents in Henan Province is good, but some problems persist. Government departments and medical institutions at all levels must continue to strengthen the conduct of antibacterial drug knowledge propaganda of parents for the prevention of bacterial drug resistance.
A Comprehensive Intensity Index and Its Application for Summertime Extratropical Cyclones in East Asia
Authors: wang sitao , Qin Yujing , Lu Chuhan , Guan Zhaoyong 
Published: August 2022

Abstract
The intensity definition and classification of the extratropical cyclone (EC) are still less studied than the tropical cyclone, due to the relatively ambiguous structure and diverse life cycle of ECs. In this study, a two-dimensional objective cyclone identification method based on outermost closed isolines is used to obtain the extratropical cyclones related datasets, and the summertime ECs in East Asia are classified by the relationship between ECs of different intensities and the corresponding precipitation. The results show that compared with the cyclone central pressure, central wind and other traditional intensity indicators, the cyclone comprehensive intensity index that is the maximum product of the EC-associated wind speed and specific humidity (vqmax), has the highest correlation with the EC-associated maximum precipitation (r = 0.74). To simplify the definition of cyclone intensity index, the vqmax within the radius of 300 km from the cyclone center (vqmax_300) is defined as the comprehensive cyclone intensity. According to the vqmax_300, the ECs in East Asia are classified into four levels. Accordingly, the EC-associated maximum precipitation increases substantially with the raising of cyclone level. In particular, 32.8% of heavy rain events in East Asia in summer are related to level-4 cyclones. Among these level-4 cyclones, the frequencies of mesoscale ECs (radius < 150 km), sub-synoptic scale ECs (150 km < radius < 500 km) and synoptic scale ECs (radius > 500 km) are 0.45%, 48.47% and 51.09%, respectively.
Identification of low temperature inducible genes of Lactuca sativa by using suppression subtractive hybridization method
Authors: Honjoh Ken-ichi , Okano Hitomi , Sasaki Mika , Kurokawa Masaru , Kimura Taiki , Shibata Kyosuke , Masuda Yoshimitsu , Miyamoto Takahisa 
Published: August 2022

Abstract

Lettuce ( Lactuca sativa ) is one of important vegetables taken as raw state. It is expected to be kept as high quality under low temperature conditions, especially freezing state. However, there are few research regarding to its molecular response to abiotic stress of lettuce. As we reported previously, lettuce plants acquire low levels of freeze tolerance. In the present paper, we have isolated 192 cDNA clones corresponding to cold induced genes of lettuce plant by using a PCR-based suppression subtractive hybridization method. Most clones were categorized into 62 distinct known genes based on homology search. Out of the corresponding genes, 45 genes were confirmed to be low-temperature-inducible with reverse transcription-qPCR. Some of the genes encoded stress-related proteins, such as late embryogenesis abundant proteins including dehydrin, which were expected to be involved in enhancement of freezing tolerance. On the other hand, some of proteins encoded by genes were suspected to be involved in suppressing the enhancement of freezing tolerance, such as vacuolar processing enzyme (VPE), adagio protein, and gigantea-like protein. In particular, VPE have been reported to be associated with program cell death, suggesting that it is negatively involved in freezing tolerance of lettuce.
The influence of CAD model continuity on accuracy and productivity of CNC machining
Authors: Kučera David , Linkeova Ivana , Stejskal Michal 
Published: August 2022

Abstract
Efficient and productive manufacturing of freeform shapes requires a suitable three-dimensional CAD model at the entrance to the CAM system. The paper deals with the impact of NURBS or B-spline CAD model geometric continuity on the accuracy and productivity of 5-axis ball-end milling of freeform surfaces. The relationships between a different order of CAD model geometric continuity and the quality of the toolpath generated in CAM system is analysed and demonstrated on example of Blisk blade profile. In order to reveal the pure effect of CAD geometry on the quality of the machined surface, linear interpolation of individual positions of CL points is considered and no further smoothing of the toolpath is applied. In addition to the commonly used indicator of toolpath quality represented by the distance of CL points, the discrete curvature of a toolpath in a form of a piecewise linear discrete curve is introduced and its dependence on the curvature and continuity of the underlying CAD model is demonstrated. It is shown that the higher order of CAD model geometric continuity significantly eliminates sharp changes in the distance of CL points and smoothes the discrete curvature of the toolpath. Finally, it is experimentally verified that increasing the continuity of the CAD model from G0 to G3, while maintaining the same cutting conditions, leads to an increase in workpiece accuracy and a reduction in machining time, without the need to smooth the toolpath generated in the CAM system.
The HASEL actuator’s muscle mimicking mechanism for enacting an upper limb smart prosthesis: A review on recent progress and challenges for future implementation
Authors: Anjum Mohammad Navid 
Published: August 2022

Abstract
Biomimicry is the method of adapting concepts from nature to produce more sustainable technologies for mankind. It is of particular interest to the biomedical soft robotic field specifically applied to smart prostheses. Unlike the typical prostheses that employs metal and geared actuators, a biomimicking smart prosthesis emphasizes on the use of highly complaint soft biocompatible materials. A recent advancement in this field is a biomimicking soft actuator known as the HASEL (Hydraulically Amplified Self-healing ELectrostatic) actuator. They represent a leap forward in the soft robotics field as they showcase many similarities with human muscles to the point that the actuator could easily be extended while in place. This paper reviews the susceptibility of the HASEL actuators for upper-limb smart prosthesis. We first reviewed the structural analysis of HASELs followed by their prevailing control system mechanisms. Finally, we concluded the paper by discussing the challenges for HASEL to be used as a smart prosthesis limiting to the upper-limb scenario.
CMFCUNet: Cascaded multi-scale feature calibration UNet for pancreas segmentation
Authors: Qiu Chengjian , Song Yuqing , Liu Zhe , Yin Jing , Han Kai , Liu Yi 
Published: August 2022

Abstract
Segmenting the pancreas from abdominal CT scans is challenging since it often takes up a relatively small region. Researchers suggested leveraging coarse-to-fine approaches to cope with this challenge. However, the coarse-scaled segmentation and the fine-scaled segmentation are either trained separately utilizing the coordinates located by the coarse-scaled segmentation mask to crop the fine-scaled segmentation input, or trained jointly utilizing the coarse-scaled segmentation mask to enhance the fine-scaled segmentation input. We argued that these two solutions are complementary to some extent and can promote each other to improve the performance of pancreas segmentation. In addition, the backbone in the coarse-scaled segmentation and fine-scaled segmentation is mostly based on UNet or UNet-like networks, where the multi-scale features transmitted from the encoder to the decoder have not been explored for vertical calibration before. In this paper, we propose a cascaded multi-scale feature calibration UNet (CMFCUNet) for pancreas segmentation where the multi-scale features in the backbone of each scaled segmentation are calibrated vertically in a pixel-wise fashion. Besides, the coarse-scaled segmentation and the fine-scaled segmentation are connected by leveraging a designed dual enhancement module (DEM). Experiments are conducted on the public NIH pancreas dataset. First, when leveraging CMFCUNet, our method increased by over 3% on the Jaccard index (JI) and nearly 1% on dice similarity coefficient (DSC) which surpasses all existing pancreas segmentation approaches. In addition, our experiments demonstrate that CMFCUNet improved the coarse-to-fine segmentation framework and outperformed the mainstream coarse-to-fine pancreas segmentation approaches. Furthermore, we also conducted ablation studies to analyze the effectiveness of the backbone (MFCUNet) and the DEM.
Introduction and Comparison of Novel Decentral Learning Schemes with Multiple Data Pools for Privacy-preserving ECG Classification
Authors: Baumgartner Martin , Veeranki Sai , Hayn Dieter , Schreier Günter 
Published: August 2022

Abstract
Purpose: Artificial intelligence and machine learning have led to prominent and spectacular innovations in various scenarios. Application in medicine, however, can be challenging due to privacy concerns and strict legal regulations. Methods that centralize knowledge instead of data could address this issue. Methods: In this work, 6 different decentralized machine learning algorithms are applied to 12-lead ECG classification and compared to conventional, centralized machine learning. Results: The results show that state-of-the-art federated learning leads to reasonable losses of classification performance compared to a standard, central model (-0.054 AUROC) while providing a significantly higher level of privacy. A proposed weighted variant of federated learning (-0.049 AUROC) and an ensemble (-0.035 AUROC) outperformed the standard federated learning algorithm. Overall, considering multiple metrics, the novel batch-wise sequential learning scheme performed best (-0.036 AUROC to baseline). Conclusion: Although, the technical aspects of implementing them in a real-world application are to be carefully considered, the described algorithms constitute a way forward towards preserving-preserving AI in medicine.
Sacubitril/Valsartan Reverses Cardiac Structure and Function in Experimental Model of Hypertension-Induced Hypertrophic Cardiomyopathy
Authors: Jeremic Jovana , Bradic Jovana , Milosavljevic Isidora , Srejo Ivan , Srejo Vladimir Zivkovic , Jeremic Nevena , Turnic Tamara Nikolic , Tanaskovic Irena , Bolevich Stefani , Jakovljevic Vladimir , Bolevich Sergey , Zivanovic Marko N , Okwose Nduka , Seklic Dragana , Milivojevic Nevena , Grujic Jelena , Velicki Lazar , MacGowan Guy , Jakovljevic Djordje G , Filipovic Nenad 
Published: August 2022

Abstract
This study evaluated the effect of sacubtril/valsartan on cardiac remodeling, molecular and cellular adaptations in experimental (rat) model of hypertension-induced hypertrophic cardiomyopathy. Thirty Wistar Kyoto rats; 10 normal (control) and 20 rats with confirmed hypertension-induced hypertrophic cardiomyopathy (HpCM) were used for this study. The HpCM group was further subdivided into untreated, and sacubitril/valsartan treated group. Myocardial structure and function were assessed using echocardiography, Langendorff’s isolated heart experiment, blood sampling and qualitative polymerase chain reaction. Left ventricular internal diameter in systole (0.5 vs 0.22 cm, P < 0.01) and diastole (0.82 vs 0.50 cm, P < 0.01) were greater in treated compared to untreated HpCM rats. Interventricular septal wall thickness in end-systole was higher in untreated and treated HpCM rats compared to controls (0.22 vs 0.20 vs 0.16 cm, P < 0.05 respectively). Fractional shortening was lower in treated compared to untreated rats (34% vs 43%, P < 0.01). Systolic and diastolic blood pressures decreased by 58 and 37 mmHg (P < 0.01) respectively in treated compared to untreated rats. Similarly, sacubitril/valsartan treatment reduced oxidative stress and apoptosis (reduced expression of Bax and Cas3 genes) compared to untreated rats. There was a regular histomorphology of cardiomyocytes, interstitium, and blood vessels in treated rats compared to untreated HpCM rats which expressed hypertrophic cardiomyocytes, with polymorphic nuclei, prominent nucleoli and moderately dilated interstitium. In experimental model of hypertension-induced hypertrophic cardiomyopathy, sacubitril/valsartan treatment led to improved cardiac structure, haemodynamic performance, and reduced oxidative stress and apoptosis. Sacubitril/valsartan thus presents as a potential therapeutic strategy resulted in hypertension-induced hypertrophic cardiomyopathy.
WITHDRAWN: Mitochondrial ribosomal protein L12 potentiates hepatocellular carcinoma by regulating mitochondrial biogenesis and metabolic reprogramming
Authors: Liu Yi , Hou Shaoshuai , Zhang Bo , Zhu Suwei , Lv Tingting , Ji Xingzhao , Zhang Yu , Ding Can , Su Tong , Yang Xiaoli , Sun Shengnan , Yang Zhen , Wan Qiang 
Published: August 2022

Abstract
Background: Mitochondrial dysfunction and metabolic reprogramming are the key features of hepatocellular carcinoma (HCC); however, the detailed mechanism has not yet been clarified. Mitochondrial ribosomal protein L12 (MRPL12) has been implicated in transcription in human mitochondria. Although the function of MRPL12 has been documented, the role of abnormal MRPL12 expression in HCC remains unknown. Here, we determined the clinical significance, functional implications, and mechanisms underlying the effects of MRPL12 in HCC. Methods: Human HCC obtain from patients was used to evaluate the role of MRPL12 in HCC. For evaluating tumor behavior, we used cell culture for in vitro experiments and for in vivo experiments we used mouse HCC xenograft model. Further we used tissue microarray, immunohistochemistry, flowcytometry, Transwell assay, and CCK-8 assay, mitochondrial DNA copy number quantification methods, and seahorse assay to clarify our hypothesis. Results: Significant upregulation of MRPL12 in patients with HCC correlated with aggressive tumor behavior and poor prognosis. MRPL12 knockdown in HCC cells attenuated cell proliferation and migration in vitro, and tumorigenicity in vivo. We observed that MRPL12 is essential for mitochondrial homeostasis. Gain- and loss-of-function of MRPL12 in HCC altered oxidative phosphorylation (OXPHOS), mitochondrial DNA content, and HCC cell proliferation and invasion. Overall, MRPL12 might play oncogenic role by activating mitochondrial OXPHOS and promoting mitochondrial biosynthesis. Yin Yang 1 (YY1) transcriptionally regulated MRPL12 expression, and YY1 knockdown inhibited MRPL12 activity and suppressed HCC cell proliferation and metastasis. The role of the phosphatidylinositol-3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway in regulating MRPL12 was confirmed. We hypothesize that the PI3K/mTOR-YY1-MRPL12 axis orchestrates HCC cell proliferation and metastasis. Conclusion: Our study provides insights into MRPL12 signaling in HCC and highlights MRPL12 as a potential therapeutic target.Trial registration: N/A.
Health risk assessment and cost-benefit analysis of agricultural soil remediation for tailing dam failure in Jinding mining area, SW China
Authors: Xu Zhongyu , Ito Lisa , Muchangos Leticia Sarmento dos , Tokai Akihiro 
Published: August 2022

Abstract
The impact of the tailing dams and the economic feasibility of the remediation process is significant for future risk management for tailing dams. In this research, we develop a hypothetical failure scenario for a tailing dam in the Jinding mining area, Southwest China. We assess the exposure with the Geo-Environmental Risk Assessment System, tier-1 model, and health impact with Disability-Adjusted Life Years (DALY). Cost and benefit are also analyzed for the following cleanup process. The result shows that the exposure dose (mg/kg-BW/d) of As, Cd, and Pb right after the dam failure is 1.07×10− 2 for As; 1.76×10− 4 for Cd; and 5.68×10− 3 for Pb, respectively. The DALY caused by heavy metal exposure is 2.63×10− 2 DALY per year, which significantly exceeds the tolerable level. This indicates that the tailing dam failure will pose a high health risk to the residents, and remediation is necessary. After remediation, the DALY is 1.24×10− 8 DALY per year, indicating the cleanup process effectively reduces the resident’s health impact. From the financial point of view, the net present value of the cleanup is $-1.02×107. This indicates that the cleanup process is not economically feasible. Sensitivity analysis shows that the amount of released tailing influences the output result. The time span for benefit estimation is also an important issue. This research shows that the impact of a tailing dam failure will be severe, and remediation may be effective but economically infeasible. Therefore, preventing tailing dam failure is the most crucial task for the local government.
Management of Gingival Hyperpigmentation by scalpel surgery and Bur abrasion.
Authors: kotb shaymaa 
Published: August 2022

Abstract
Natural Smile is the key to beauty . Dark gum is the most aesthetic problem that affects the smile of a large group of people especially those with high smile lines . These dark gingiva are considered natural melanin pigments contributing to the endogenous pigmentation of the gingiva . Aesthetics dentistry is a crucial and challenging era for all dentists.The gingival depigmentation procedure is a plastic periodontal surgery in which the gingival epithelium is scrapped with different techniques to remove the dark colour of the gingiva. The aim of this study was to shed light on the treatment modalities of gingival hyperpigmentation using scalpal surgery and/or bur abrasion techniques.Objective: The main concern of all dentists is to help patients feel satisfaction and self-confidence while talking and smiling. Treatment modalities for this condition include the surgical scalpel method ,cryotherapy ,electrotherapy and laser irradiation . In the present case series,the scraping technique was used which is simple, effective, and yields good results along with good patient satisfaction.Methods: Gingival depigmentation of a 19-year-old female patient was performed under local anesthesia with the scraping technique using a 15 no. Bard-Parker blade and in another case using a diamond bur at high speed for depigmentation .Discussion: The advantages of the procedure show psychological satisfaction to the patient. This case report describes the procedure for depigmentation of gingiva by surgical intervention which was successful and the patient was satisfied with the resultConclusion: Depigmentation of gingiva is a minimally invasive technique that can be performed at any dental clinic by using 15 no. The Bard-Parker blade with scraping technique which is simple, easy to perform, cost-effective, and above all, causes less discomfort and is esthetically acceptable to the patient.
Immediate dental implants, clinical,radiographic,aesthetic outcomes,advantages and disadvantages . (case report)
Authors: kotb shaymaa 
Published: August 2022

Abstract
Immediate implantation in fresh extraction sockets is regarded as a treatment modality that appears to give various advantages over the delayed traditional type. Thus, the aim of this case series was to assess the clinical, radiographic, and esthetic outcomes of the immediatelyplaced implants and describe some of the essential clinical factors to consider when selectingpatients for implants such as ,the thickness of socket walls, thickness of gingival drapes, and optimal position of the implant, and patient factors such as medical conditions , hygiene and smoking cessation., as well as the benefits and drawbacks of this treatment modality .Objective: to restore the normal function, aesthetics, speech, and health of patients . The ability to achieve these characteristics with the use of immediate dental implants in the rehabilitation of partially and fully edentulous jaws has become a well-established and accepted modern therapeutic modality techniqies.Methods: Immediate dental implant placement was placed at the freash extraction socket . Radiographic evaluation was performed to assess the amount of marginal bone loss, and patient assessed outcomes were also evaluated at the 6 month follow-up . All implants were successful functionally without any pain or inflammation, with optimal soft tissue health and esthetics, and with minimal radiographic marginal bone loss at the last follow-up visit (3 months after) Results : There were an excellent clinical ,radiographical and aesthetics outcomes in immediately placed implants . Conclusion: Immediate implants showed excellent results regarding implant success ,survival and esthetic outcomes with high patient satisfaction in this study. Evidence available indicates that it is a successful procedure that may benefit patients. However, careful planning and case selection are needed to ensure implant success and final esthetic outcomes.
Synchronizing Complex Networks on Time Scales: An Impulse-Quantizing multi-group Strategy
Authors: Li Luyan , Bin Honghua , Huang Zhenkun , Sun Jianqiao 
Published: August 2022

Abstract
This paper presents synchronization of complex network on time scales via impulse-quantizing control. A delay-partitioning group strategy is proposed and impulse-quantizing control is designed to derive theoretical criteria ensuring scale-type synchronization of complex networks. Our results show that synchronization of complex networks on time scales can be realized by controlling delay-partitioning subgroup nodes with impulsive quantization. The theoretical results give scale-limited sufficient conditions for quantized synchronization relying on control gains, impulsive intervals and delays. A numerical simulation is given to demonstrate the effectiveness of the theoretical results.