bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infantilization across the life span: A large-scale internet study suggests that emotional abuse is especially damaging
Authors: Epstein Robert , Bock Sara D. , Drew Megan J. , Scandalis Zoë 
Published: November 2022

AbstractWhen competent adults are treated like children, negative outcomes sometimes follow. We used a concurrent study design to conduct an internet-based study to determine how infantilization varies by demographic category and which types of infantilization might be most harmful. The test, which measured 15 types of infantilization, was taken by 32,118 people (mean age 27.6) from 153 countries (most from the United States). Test scores were correlated with self-reported happiness, depression, anger, sense of control, and personal and professional success, and regression analyses consistently showed that of the 15 types of infantilization we measured, emotional abuse was by far the best predictor of adverse outcomes. Infantilization was highest during the teen years and decreased gradually throughout adulthood. Effects were found for gender, education, and sexual orientation, with vulnerable groups more subject to infantilization. Our data, collected between 2011 and 2020, appear to parallel recent increases in authoritarianism and intolerance, with total infantilization scores increasing by 30.1% over this period.
Transcriptome Analysis Reveals the Anti-Tumor Mechanism of Eucalyptol Treatment on Neuroblastoma Cell Line SH-SY5Y
Authors: Gao Kai , Wu Congying , Li Yanlong , Lu Jian , Jiang Yuwu 
Published: November 2022

AbstractEucalyptol (1.8-cineole), an active component in traditional Chinese medicine Artemisia argyi for moxibustion. Previous studies have shown that eucalyptol has anti-tumor effects on leukemia and colon cancer. Nonetheless, the effect and mechanism of eucalyptol on neuroblastoma remains unclear. In the present study, we intended to reveal the effect and mechanism of eucalyptol treatment on the neuroblastoma cell line SH-SY5Y through transcriptome analysis. In the group treated with eucalyptol, 566 brain genes were up-regulated, while 757 genes were down-regulated. GO function analysis showed that positive regulation of cell cycle was down-regulated in biological processes. Meanwhile, cancer-related pathways were identified in KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis, including pathways in cancer, PI3K-Akt signaling pathway, cAMP signaling pathway, TGF-beta signaling pathway, Hippo signaling pathway, p53 signaling pathway, and additional pathways. Furthermore, we found a key gene, such as MYC, by constructing a network of cancer related pathways with differentially expressed genes and transcription factor analysis. In conclusion, our research indicates that MYC might play a central role in the anit-tumor mechanisms of eucalyptol.
Phenology of grassland plants responds to urbanization
Authors: Christmann Tina , Kowarik Ingo , Bernard-Verdier Maud , Buchholz Sascha , Hiller Anne , Seitz Birgit , Lippe Moritz von der 
Published: November 2022

AbstractUnderstanding phenological responses of plants to changing temperatures is important because of multiple associated ecological consequences. Cities with their urban heat island can be used as laboratories to study phenological adaptation to climate change. However, previous phenology studies focused on trees and did not disentangle the role of micro-climate and urban structures.We studied reproductive phenology of dry grassland species in response to micro-climate and urbanization in Berlin, Germany. Phenological stages were recorded weekly at the individual plant level for five native grassland species across 30 dry grassland sites along an urbanization and temperature gradient. We estimated 50% onset probabilities for flowering and seed maturation of populations, and analysed variation in onset dates using regression models.Early flowering species significantly advanced flowering phenology with increasing mean air temperature but were little influenced by urbanization. By contrast, late-flowering species showed significant phenological responses to both air temperature and urbanization, possibly because micro-climate was most affected by urbanization in late summer. Surprisingly, not all grassland species showed an advanced phenology with increasing intensity of urbanization.This contradicts observed patterns for urban trees, indicating that phenological shifts in urban areas cannot be generalized from the observation of one growth form or taxonomic group. Growth form appears as a possible determinant of phenological responses. Results suggest that the phenology of dry grassland species may directly respond to the urban heat island, albeit with variable direction and magnitude. This has implications for ecosystem services, shifted allergy seasons, changes of biogeochemical cycles and potential ecological mismatches.
Presence and localization of apelin and its cognate receptor in canine testes using immunohistochemical and RT-PCR techniques
Authors: Troisi Alessandro , Dall’Aglio Cecilia , Maranesi Margherita , Orlandi Riccardo , Suvieri Chiara , Pastore Sara , Bazzano Marilena , Martínez-Barbitta Marcelo , Polisca Angela 
Published: November 2022

AbstractApelin, a member of the adipokine family, is a novel endogenous peptide which regulates the male reproductive system of mammals by interacting with a specific receptor. Recent studies have highlighted that apelin may play a role in the regulation of reproduction by reducing testosterone production and inhibiting LH secretion. To the best of our knowledge, there is no available data on the presence of the apelin and its receptor in canine testes. Therefore, the aim of this study was to reveal the presence of apelin and evaluate its distribution in the canine testes using immunohistochemical and RT-PCR techniques. For this purpose, five fertile and healthy male dogs were subjected to elective orchiectomy. The immunohistochemical reaction revealed the presence of apelin and its receptor in the canine testes. Apelin was localized in spermatids and spermatozoa with a positive signal in the “acrosomal bodies”. As regards the apelin receptor, a positive immunoreaction was detected in the cytoplasm of the cells localized near to the basal membrane of the seminiferous tubules and in the cytoplasm of Leydig cells. The RT-PCR analysis showed the presence of transcripts for apelin and apelin receptor in all of the samples under study. A 35kDa band confirmed apelin receptor protein expression in all of the samples analysed. In conclusion, the paracrine and endocrine role of apelin and its cognate receptor on male reproduction reported in humans and laboratory animals could also be hypothesized in dogs.
Development of immunodiagnostic tools for in situ investigation of Ovis aries papillomavirus 3 (OaPV3)
Authors: Cacciotto Carla , Dore Gian Mario , Anfossi Antonio Giovanni , Tore Gessica , Varoni Maria Vittoria , Demontis Maria Piera , Antuofermo Elisabetta , Pittau Marco , Alberti Alberto 
Published: November 2022

AbstractCutaneous squamous cell carcinoma (cSCC) is a malignant lesion characterized by proliferation and transformation of keratinocytes in the epidermis and infiltrating derma. cSCC is reported in domestic and wild animal species, worldwide. The occurrence and development of cSCC rely on synergic multifactorial conditions, most importantly sunlight exposure and Papillomavirus (PV) infection. In sheep, the development of such lesions represents a threat both to animal welfare and milk production. Ovis aries papillomavirus 3 (OaPV3) is the main cSCC viral determinant and oncogenic properties of viral E6 and E7 proteins were preliminarily investigated. However, E6 and E7 role and mechanisms resulting in cSCC have not been fully clarified, mainly due to the lack specific immunological tools, such as antibodies for in situ detection of ovine papillomavirus. This paper reports the development of specific serological tools for the investigation of OaPV3 pathogenicity, and their preliminary use to screen 4 ovine cSSC formalin-fixed paraffin embedded tissues. Relevance of immunological tools to investigation of viral biological properties and diagnosis are also discussed.
Micronutrients Deficiencies in Candidates of Bariatric Surgery: Results from a Single Institution over a 1-Year Period
Authors: Berardi Giovanna , Vitiello Antonio , Abu-Abeid Adam , Schiavone Vincenzo , Franzese Antonio , Velotti Nunzio , Musella Mario 
Published: November 2022

Abstract
Background
Micronutrient deficiencies represent a common condition after bariatric surgery (BS). The prevalence of these nutritional disorders before BS is still debated. The aim of our study was to retrospectively evaluate the prevalence of micronutrient deficiencies in candidates for BS.

Methods
A prospectively maintained database of our institution was searched to find all patients who underwent surgery between January and December 2021. The following data were collected: age, gender, body mass index (BMI), obesity-associated diseases, and preoperative serum levels of vitamin B12, folate, and vitamin D.

Results
A total of 174 patients were included in our study. Mean age and BMI were 39.2 ± 11.4 years and 44.3 ± 7.1 kg/m2, respectively. One hundred and thirty-nine patients (79.9%) had at least one preoperative micronutrient disorder, with vitamin D deficiency being the most common (116, 66.7%), followed by a deficit of folate (76, 43.7%) and vitamin B12 (10, 5.7%). Forty-seven (27%) individuals had insufficient levels of vitamin D. Comparison of deficiencies between sexes showed that vitamin B12 < 20 ng/ml was significantly more frequent in women (p = 0.03). DLP showed a mild significant effect on folate levels (p = 0.01), while the association of HNT and T2DM had a mild significant effect on vitamin B12 (p = 0.02).

Conclusions
Preoperative micronutrient deficiencies were frequently found in candidates for BS. Approximately 90% of patients had deficient or insufficient serum levels of vitamin D preoperatively. Almost half of the patients had a preoperative deficit of folate, and vitamin B12 deficiency was significantly more frequent in the female population. It is mandatory to screen all patients undergoing BS for vitamin deficiencies before surgery.
Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2/HO-1 Pathway
Authors: Samy Doaa M. , Mostafa Dalia Kamal , Saleh Samar R. , Hassaan Passainte S. , Zeitoun Teshreen M. , Ammar Gamal A. G. , Elsokkary Nahed H. 
Published: November 2022

AbstractThe peri- and post-menopausal periods have been described as the “window of vulnerability” for the development of depressive symptoms that impair women activities and quality of life. The etiopathogenesis of these symptoms is multifactorial and may confer resistance to traditional antidepressants. Attention is now directed toward phytochemicals for their pleiotropic functions and safer profiles. This study investigated the possible perturbation of the nuclear factor erythroid 2–related factor 2 (Nrf2) signaling pathways as an underlying mechanism of post-ovariectomy depression and highlighted the potential benefits of carnosic acid (CA) on the associated behavioral, biochemical, and histopathological alterations. Female Balb/c mice were randomly assigned to be sham-operated or ovariectomized (OVX). After 3 weeks, OVX mice received either a vehicle, CA (20 mg/kg/day), or tin protoporphyrin IX (SnPP-IX; a heme oxygenase-1 (HO-1) inhibitor; 50 μmol/kg/day) for 3 weeks. Our findings revealed that OVX mice had depressive but not anxiety-like behavior. Suppressed Nrf2 and its downstream signaling, and augmented proinflammatory markers were observed in both the hippocampus and prefrontal cortex. CA treatment alleviated depressive behavior, induced the expression of Nrf2, HO-1, thioredoxin-1, and brain-derived neurotrophic factor, and enhanced serotonin levels. CA also suppressed oxidative stress, reduced TNF-α, IL-1β, and iNOS mRNA expression, and ameliorated OVX-induced histopathological changes. SnPP-IX aggravated post-OVX behavioral, neurobiochemical, and histological deteriorations, and reduced CA-protective effects. In conclusion, Nrf2/HO-1 signaling suppression and the associated proinflammatory state are key mechanisms in post-OVX depression. CA exerts multifaceted neuroprotection in OVX mice and represents a promising candidate for clinical evaluation as an antidepressant.
Restoring After Central Nervous System Injuries: Neural Mechanisms and Translational Applications of Motor Recovery
Authors: Gao Zhengrun , Pang Zhen , Chen Yiming , Lei Gaowei , Zhu Shuai , Li Guotao , Shen Yundong , Xu Wendong 
Published: November 2022

AbstractCentral nervous system (CNS) injuries, including stroke, traumatic brain injury, and spinal cord injury, are leading causes of long-term disability. It is estimated that more than half of the survivors of severe unilateral injury are unable to use the denervated limb. Previous studies have focused on neuroprotective interventions in the affected hemisphere to limit brain lesions and neurorepair measures to promote recovery. However, the ability to increase plasticity in the injured brain is restricted and difficult to improve. Therefore, over several decades, researchers have been prompted to enhance the compensation by the unaffected hemisphere. Animal experiments have revealed that regrowth of ipsilateral descending fibers from the unaffected hemisphere to denervated motor neurons plays a significant role in the restoration of motor function. In addition, several clinical treatments have been designed to restore ipsilateral motor control, including brain stimulation, nerve transfer surgery, and brain–computer interface systems. Here, we comprehensively review the neural mechanisms as well as translational applications of ipsilateral motor control upon rehabilitation after CNS injuries.
Cannabis and Intentional Self-injury: a Narrative Review
Authors: Denissoff Alexander , Levola Jonna , Niemelä Solja , Mustonen Antti 
Published: November 2022

Abstract

Purpose of Review
Observational studies assessing the association of cannabis use with subsequent intentional self-injury have reported mixed findings. Longitudinal studies examining the association of cannabis use with subsequent suicide death are notably rare. Our objective was to review longitudinal studies examining cannabis use and subsequent self-harm, suicide attempt, or suicide death.

Recent Findings
Few population-based studies have focused on self-harm with considerable variability across studies in how this outcome has been operationalized. Studies assessing the association between cannabis use and suicide attempt are equivocal in their conclusions and heterogenous in terms of samples utilized and assessment of confounding bias. The results of one meta-analysis were suggestive of dose dependency. For suicide death, the findings are inconsistent, and there is reason for concern of selection bias.

Summary
The existing evidence base on these associations is not yet rigorous enough to allow drawing conclusions on causality. However, cannabis might be seen as an adverse prognostic marker for intentional self-injury.
Negotiating border-crossings when ‘adult education’ meets ‘vocational learning’. Comparative historical notes on defining the ‘research object’
Authors: Hake Barry John 
Published: November 2022

AbstractThis paper offers a theoretical perspective on socio-historical research addressing the social organisation of communication and learning as cultural practices. It is critical of mapping the field of ‘adult education’ in terms of ‘absences’ regarding the historical dimensions of ‘organised adult learning’ investigated. It offers a comparative exploration of vocational dimensions of organised adult learning that characterise divergent historiographies in the Netherlands and Germany until 1945. Post-1945 policy repertoires are explored in terms of the socio-historical shift from ‘collective employability’ repertoires stressing permanent education social advancement towards the construction of neoliberal repertoires from the late 1960s articulating ‘individualised employability’. The conclusion argues that research should focus on recovering a critical perspective regarding shifts and breaks in historical conjunctions of cultural practices that characterise relationships between the ‘adult’ and ‘vocational’ dimensions of organised adult learning.
The Effects of Different Theta and Beta Neurofeedback Training Protocols on Cognitive Control in ADHD
Authors: Bluschke Annet , Eggert Elena , Friedrich Julia , Jamous Roula , Prochnow Astrid , Pscherer Charlotte , Schreiter Marie Luise , Teufert Benjamin , Roessner Veit , Beste Christian 
Published: November 2022

Abstract
Neurofeedback (NF) is an important treatment for attention deficit/hyperactivity disorder (ADHD). In ADHD, cognitive control deficits pose considerable problems to patients. However, NF protocols are not yet optimized to enhance cognitive control alongside with clinical symptoms, partly because they are not driven by basic cognitive neuroscience. In this study, we evaluated different EEG theta and/or beta frequency band NF protocols designed to enhance cognitive control. Participants were n = 157 children and adolescents, n = 129 of them were patients with ADHD (n = 28 typically developing (TD) controls). Patients with ADHD were divided into five groups in the order of referral, with four of them taking part in different NF protocols systematically varying theta and beta power. The fifth ADHD group and the TD group did not undergo NF. All NF protocols resulted in reductions of ADHD symptoms. Importantly, only when beta frequencies were enhanced during NF (without any theta regulation or in combination with theta upregulation), consistent enhancing effects in both response inhibition and conflict control were achieved. The theta/beta NF protocol most widely used in clinical settings revealed comparatively limited effects. Enhancements in beta band activity are key when aiming to improve cognitive control functions in ADHD. This calls for a change in the use of theta/beta NF protocols and shows that protocols differing from the current clinical standard are effective in enhancing important facets of cognitive control in ADHD. Further studies need to examine regulation data within the neurofeedback sessions to provide more information about the mechanisms underlying the observed effects.
A systematic review of neoadjuvant targeted therapy in locally advanced thyroid cancer
Authors: Huang Nai-si , Wang Yu , Wei Wen-jun , Xiang Jun , Chen Jia-ying , Guan Qing , Wang Yun-jun , Lu Zhong-wu , Ma Ben , Hu Jia-qian , Wang Yu-long , Ji Qing-hai 
Published: November 2022

Abstract
Introduction
Locally advanced thyroid cancer refers to thyroid cancer that invades important structures of the neck, with poor prognosis. Neoadjuvant targeted therapy has the potential to increase the R0/1 resection rate in locally advanced thyroid cancer and improve the outcome in these patients.

Methods
We conducted a systematic review of studies that reported neoadjuvant targeted therapy in locally advanced thyroid cancer. Individual patient data was extracted from eligible studies. Objective response rate (ORR) and R0/1 resection rate were calculated.

Results
Sixteen studies and 32 patients were included into analysis, including 18 differentiated thyroid cancer (DTC), 3 medullary thyroid cancer (MTC), 8 anaplastic thyroid cancer (ATC) and 3 poor-differentiated thyroid cancer (PDTC). Most patients were stage T4a (53.1%) and T4b (28.1%). 81.3% patients had regional lymph node metastasis and 37.5% had distant metastasis. RET mutated MTC and BRAF mutated ATC were treated with selective RET inhibitor and selective BRAF/MEK inhibitors. Other treatment regimens were multitarget tyrosine kinase inhibitors (mTKIs). The average duration of treatment was 4.3 months (SD = 4.1). The overall ORR was 78.1% (95%CI: 60.0%–90.7%), and the R0/1 resection rate for the intention to treat population was 78.1% (95%CI: 60.0%–90.7%). With a median follow-up time of 12.1 months, 1 DTC patient and 3 ATC patients died of the disease.

Conclusions
Neoadjuvant targeted therapy was a new treatment option for locally advanced thyroid cancer and might improve the R0/1 resection rate in selective cases. However, more clinical trials with longer follow-up time are awaited to confirm the clinical benefit of neoadjuvant targeted treatment.
The role of ion magnetization on plasma generation in a magnetic nozzle rf device
Authors: Filleul Félicien , Caldarelli Antonella , Boswell Rod , Charles Christine , Rattenbury Nicholas , Cater John 
Published: November 2022

AbstractTwo dimensional mappings of the floating potential, Ar II emission and ion saturation currents are used to characterize an 80 cm long magnetized rf plasma column. The data brings new evidence supporting that the level of ion magnetization under the rf loop antenna plays an important role for the efficient generation of plasma over an extended region when the magnetic nozzle is sufficiently separated from the antenna. Densities up to $$10^{18}$$

10
18

m$$^{-3}$$

-
3

and a blue core are observed for an rf power of 200 W and magnetic fields above 400 G when ions are magnetized. The local wall charging under the antenna is probed and observed to change coherently with the local ion magnetization and seems critical to the global creation and transport of energetic electrons, which are indirectly observed far from the antenna when the ion Larmor radius is much smaller than the glass tube radius over the entire region of investigation.
Rethinking the EU’S ‘Monetary Constitution’: legal theories of money, the Euro, and transnational law
Authors: Chadwick Anna 
Published: November 2022

AbstractIn recent years, legal scholars have dismantled influential economic accounts of the private nature of money, demonstrating that money is better understood as a ‘governance project’ and a public resource that is created and regulated by the state. Legal theories of money could lend support to the ECB’s recent use of ‘unorthodox’ monetary policy to stabilise the euro, and could further support proposals for the innovative use of monetary policy to combat inequality. However, legal writing on money to date has primarily sought to challenge neoclassical economics – a body of thought that denies the impact that distributions of credit by the state play in shaping processes of value formation in the economy. Two further dimensions of the nature of money have received less attention from legal scholars to date: first, the question of how money comes to have an economic value (an important component of ‘moneyness’), and, second, how the international functions of credit money as currency in international trade and finance may limit the capacities of governments to manage money differently. In this article, I offer a revised account of the legal nature of money that is more attentive to the transnational nature of the legal regimes and institutions that enable the production of sovereign credit monies in the contemporary global political economy. My analysis complicates both the suggestion that the ECB can address inequality in the eurozone by means of unorthodox monetary policy and the widely made counter-argument that the only solution to the constitutional crisis in the European Union (EU) is the creation of a political sovereign imbued with stronger fiscal powers. I find that unless the current transnational legal arrangements that enable the production and governance of money are addressed, no states will be able to act as ‘centralised and legitimate political authorities’ that can control capitalist credit money in accordance with democratic imperatives.