bluuebunny/crossref_metadata_2025_split huggingface dataset:
GLRaV-2 protein p24 suppresses host defenses by interaction with a RAV transcription factor from grapevine
Authors: Zhang Chenwei , Wang Xianyou , Li Hanwei , Wang Jinying , Zeng Qi , Huang Wenting , Huang Haoqiang , Xie Yinshuai , Yu Shangzhen , Kan Qing , Wang Qi , Cheng Yuqin 
Published: April 2022

Abstract
Grapevine leafroll-associated virus 2 (GLRaV-2) is a prevalent virus associated with grapevine leafroll disease, but the molecular mechanism underlying GLRaV-2 infection is largely unclear. Here, we report that 24-kDa protein (p24), an RNA-silencing suppressor (RSS) encoded by GLRaV-2, promotes GLRaV-2 accumulation via interaction with the B3 DNA-binding domain of grapevine (Vitis vinifera) RELATED TO ABSCISIC ACID INSENSITIVE3/VIVIPAROUS1 (VvRAV1), a transcription factor belonging to the APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) superfamily. Salicylic acid-inducible VvRAV1 positively regulates the grapevine pathogenesis-related protein 1 (VvPR1) gene by directly binding its promoter, indicating that VvRAV1 may function in the regulation of host basal defense responses. p24 hijacks VvRAV1 to the cytoplasm and employs the protein to sequester 21-nt double-stranded siRNA together, thereby enhancing its own RSS activity. Moreover, p24 enters the nucleus via interaction with VvRAV1 and weakens the latter’s binding affinity to the VvPR1 promoter, leading to decreased expression of VvPR1. Our results provide a mechanism by which a viral RSS interferes with both the antiviral RNA silencing and the AP2/ERF-mediated defense responses via the targeting of one specific host factor.
Patient Experienced Symptom State in rheumatoid arthritis: sensitivity to change in disease activity and impact
Authors: Duarte Catiá , Kvien Tore K , Sexton Joe , Santos Eduardo , de Wit Maarten , Gossec Laure , da Silva Jose A P 
Published: April 2022

Abstract

Objectives
The Patient Experienced Symptom State (PESS) is a single-question, patient-reported outcome that is validated to assess global disease impact in RA. This study addresses its sensitivity to change, and reliability.

Methods
Disease activity, disease impact in the seven domains of RA Impact of Disease (RAID) and PESS were assessed in patients with RA from the NOR-DMARD registry, at two visits, 6 months apart. The PESS over the last week was scored at five levels, from ‘very bad’ to ‘very good’. Disease impact and disease activity were compared between patients who improved, maintained or worsened PESS over time, through one-way analysis of variance, with post hoc Bonferroni correction. Correlations between changes in these parameters were assessed through Spearman’s correlation coefficient. Sensitivity to change was assessed by standardized response mean (SRM) between the two visits. Reliability was analysed through intraclass correlation coefficient (ICC) between the two visits in patients with stable disease activity and impact.

Results
In 353 patients [76.8% females, mean (s.d.) 9.9 (9.6) years disease duration], improvement in PESS level was associated with substantial improvements in mean impact in all domains as well as disease activity (P &lt;0.02). PESS change was moderately to strongly correlated with RAID domains and disease activity (rho: 0.4–0.7). PESS was responsive to change (SRM: 0.65, 95% CI: 0.54, 0.76), particularly among RAID responders (SRM: 1.79, 95% CI: 1.54, 1.99). PESS was moderately reliable in patients with stable condition (ICC: 0.72, 95% CI: 0.52, 0.83).

Conclusion
PESS is valid, feasible, reliable and responsive, representing an opportunity to improve the assessment of disease impact with minimal questionnaire burden.
Reassessing the phylogeny and divergence times of sloths (Mammalia: Pilosa: Folivora), exploring alternative morphological partitioning and dating models
Authors: Casali Daniel M , Boscaini Alberto , Gaudin Timothy J , Perini Fernando A 
Published: April 2022

AbstractPhylogenetic relationships among sloths (Folivora) have been extensively studied in the past few decades using maximum parsimony approaches. Recently, Bayesian phylogenetic methods also began to be employed for this task, with advances in methods for data partitioning and tip-dating analyses leading to exciting new possibilities in morphological phylogenetics. In this context, we assembled the largest morphological data set ever applied to sloths and reassessed their phylogeny and divergence times, evaluating alternative models of partitioning and dating in a Bayesian framework. The updated phylogeny of sloths is largely in agreement with previous morphological studies, with Bradypus recovered as sister to Eufolivora, the presence of two major sloth clades (Mylodontoidea and Megatherioidea) and Choloepus among Megalonychidae. However, the present study yields some important advances in understanding the relationships of genera with historically unresolved or controversial allocations. The major sloth clades diversified from the Late Eocene to the Early Miocene. Homoplasy-based partition models outperformed anatomical partitioning and unpartitioned analyses, with considerable impacts on topology and posterior probabilities. Estimates obtained using homoplasy-partitioned models with Bayesian analyses were in strong agreement with those of maximum parsimony. We emphasize the importance of model comparison with Bayes factors and the assessment of synapomorphies in Bayesian morphological phylogenetics.
The subtle Lisfranc injury
Authors: Burfeind Victoria Hart , Bernard Stephanie 
Published: April 2022

ABSTRACT
A subtle Lisfranc ligament disruption is a rare but potentially devastating injury to the midfoot. If the injury is recognized and treated early, the patient can avoid future arthritic changes and the need for more extensive surgery. The use of bilateral weight-bearing radiographs can aid in the early detection of this subtle injury. This article describes a patient who presented to an orthopedic office with complaints of right foot pain and an inability to participate in physical activity following an intramural sports injury 3 months earlier, and was eventually diagnosed with Lisfranc injury.
PA clinical postgraduate training
Authors: Grabenkort Rob , Hilton Ginny 
Published: April 2022

ABSTRACT
Clinical postgraduate training (CPGT) for physician assistants (PAs) began in 1971. A half-century later, the United States has 144 programs in 33 specialties. A growing and aging population, specialization in healthcare, and changes in graduate medical education have created new opportunities for PAs to consider this alternative following graduation. Postgraduate training is attractive to PA graduates who desire advanced skills and deeper understanding in a medical or surgical specialty. This article describes the history of CPGT programs, training, and establishment of an accreditation process for educational standardization.
Robotic Spine Surgery: Past, Present, and Future
Authors: Perfetti Dean C. , Kisinde Stanley , Rogers-LaVanne Mary P. , Satin Alexander M. , Lieberman Isador H. 
Published: April 2022

Study Design.
Systematic review.

Objective.
The aim of this review is to present an overview of robotic spine surgery (RSS) including its history, applications, limitations, and future directions.

Summary of Background Data.
The first RSS platform received United States Food and Drug Administration approval in 2004. Since then, robotic-assisted placement of thoracolumbar pedicle screws has been extensively studied. More recently, expanded applications of RSS have been introduced and evaluated.

Methods.
A systematic search of the Cochrane, OVID-MEDLINE, and PubMed databases was performed for articles relevant to robotic spine surgery. Institutional review board approval was not needed.

Results.
The placement of thoracolumbar pedicle screws using RSS is safe and accurate and results in reduced radiation exposure for the surgeon and surgical team. Barriers to utilization exist including learning curve and large capital costs. Additional applications involving minimally invasive techniques, cervical pedicle screws, and deformity correction have emerged.

Conclusion.
Interest in RSS continues to grow as the applications advance in parallel with image guidance systems and minimally invasive techniques.

IRB Approval.
N/A.
It Is Not What Happens to You But How You React to It That Matters
Authors: Dodd Dorian R. , Johnson Emma L. , Hazzard Vivienne M. , Cao Li , Crosby Ross D. , Wonderlich Stephen A. 
Published: April 2022

Abstract
We examined the moderating role of posttraumatic stress disorder (PTSD) in the association between trauma and impulsive behaviors. Adult women (N = 97) with a history of childhood sexual abuse (CSA; n = 26), rape in adulthood (n = 21), both CSA and adult rape (n = 25), or no history of sexual trauma (n = 25) completed self-report questionnaires. PTSD symptoms were positively associated with self-harm and with stealing and accident proneness, but not with sexual impulsivity. Trauma group had no independent associations with impulsive behaviors. PTSD reexperiencing symptoms interacted with trauma group such that reexperiencing symptoms were positively associated with self-harm for the two trauma groups that included CSA but not for the control and adult rape–only groups. Overall, results indicate that PTSD symptoms—more so than the occurrence of trauma itself—associate with impulsive behavior. Results highlight the importance of assessing posttraumatic symptomatology, and not just trauma occurrence, when aiming to prevent or treat impulsive behaviors.
Psychological Stress Reported at the Start of the COVID-19 Pandemic and Subsequent Stress and Successful Coping in Patients With Rheumatic Diseases
Authors: Duculan Roland , Jannat-Khah Deanna , Wang Xin A. , Mancuso Carol A. 
Published: April 2022

Objective
In a cohort assembled during the height of mortality-associated coronavirus disease 2019 (COVID-19) in New York City, the objectives of this qualitative-quantitative mixed-methods study were to assess COVID-related stress at enrollment with subsequent stress and clinical and behavioral characteristics associated with successful coping during longitudinal follow-up.

Methods
Patients with rheumatologist-diagnosed rheumatic disease taking immunosuppressive medications were interviewed in April 2020 and were asked open-ended questions about the impact of COVID-19 on psychological well-being. Stress-related responses were grouped into categories. Patients were interviewed again in January–March 2021 and asked about interval and current disease status and how well they believed they coped. Patients also completed the 29-item Patient-Reported Outcomes Measurement Information System (PROMIS-29) measuring physical and emotional health during both interviews.

Results
Ninety-six patients had follow-ups; 83% were women, and mean age was 50 years. Patients who reported stress at enrollment had improved PROMIS-29 scores, particularly for the anxiety subscale. At the follow-up, patients reported persistent and new stresses as well as numerous self-identified coping strategies. Overall coping was rated as very well (30%), well (48%), and neutral-fair-poor (22%). Based on ordinal logistic regression, variables associated with worse overall coping were worse enrollment–to–follow-up PROMIS-29 anxiety (odds ratio [OR], 4.4; confidence interval [CI], 1.1–17.3; p = 0.03), not reporting excellent/very good disease status at follow-up (OR, 2.7; CI, 1.1–6.5; p = 0.03), pandemic-related persistent stress (OR, 5.7; CI, 1.6–20.1; p = 0.007), and pandemic-related adverse long-lasting effects on employment (OR, 6.1; CI, 1.9–20.0; p = 0.003) and health (OR, 3.0; CI, 1.0–9.0; p = 0.05).

Conclusions
Our study reflects the evolving nature of COVID-related psychological stress and coping, with most patients reporting they coped well. For those not coping well, multidisciplinary health care providers are needed to address long-lasting pandemic-associated adverse consequences.
Press-fit process fault diagnosis using 1DCNN-LSTM method
Authors: Ye Xialiang , Li Minbo 
Published: April 2022

Purpose
Press-fit with force and displacement monitoring is commonly adopted in automotive mechatronic system assembling. However, suitable methods for the press-fit study are still at initial investigation phase. The sequential data physical meaning, small data sets from different resources and computing efficiency should be considered. Therefore, this paper aims to better identify press-fit fault types.

Design/methodology/approach
This paper proposed one-dimensional convolutional neural network (1DCNN)–long short-term memory (LSTM) method to perform press-fit fault diagnosis into automotive assembling practice which is in accordance with current product development procedure. Specialized data augmentation method is proposed to merge different data resources and increase the sample size. Referring one-way sequential data characteristics, LSTM and batch normalization layers are integrated in 1DCNN to improve the performance.

Findings
The proposed 1DCNN-LSTM method is feasible with small data sets from different sources. Using data augmentation to make data unified and sample size increased, the accuracy could reach more than 99%. Training time has reduced from 90 s/Epoch to 4 s/Epoch compare to pure LSTM method.

Originality/value
The proposed method shows better performance with less training time compared to LSTM. Therefore, the method has practical value and is worthy of industrial application.
Manufacturers' efficiency disparity: a comparative analysis in the Southeast Asian region
Authors: Anh Dao Le Trang , Gan Christopher 
Published: April 2022

PurposeThe study aims to investigate the profitability and marketability efficiency scores and determinants of 899 listed manufacturers in six Southeast Asian countries: Indonesia, Malaysia, the Philippines, Singapore, Thailand and Vietnam.Design/methodology/approachThe study employs the bootstrap two-stage data envelopment analysis (DEA) to measure profitability and marketability efficiencies of Southeast Asian manufacturers. The study uses the panel-data fractional regression model (FRM), which is an advantageous method that is suitable for the fractional response variables and applicable to time-differing heterogeneity, to investigate the determinants of Southeast Asian manufacturers' efficiencies.FindingsThe study demonstrates that listed manufacturers in Indonesia and Singapore achieve the highest average profitability and marketability efficiencies among the six Southeast Asian countries. The study also shows that the cash ratio, institutional ownership, headcount and technology-application positively affect Southeast Asian-listed manufacturers' profitability and marketability efficiencies at different levels of significance.Originality/valueThe current study is the first assessment of the listed manufacturers' profitability and marketability efficiencies in Southeast Asian countries, which consist of different market levels (developed, emerging and frontier markets). The study is a reference source for regional investors, manufacturers' managers and governments to make appropriate decisions in investing, managing and enhancing the development of the Southeast Asian manufacturing sector.
Drinking in style? Literature review of luxury wine consumption
Authors: Wright Dannielle K. , Yoon Hyunsun , Morrison Alastair M. , Šegota Tina 
Published: April 2022

PurposeThis paper aims to review and map the landscape of luxury wine consumption in multidisciplinary literature. It highlights the key themes of analysis, consumer markets and common behaviours of luxury wine consumption.Design/methodology/approachThe paper analyses 85 articles on luxury wine consumption using Leximancer and content analysis.FindingsSix main topics in the extant literature are identified as follows: product perception, wine price, wine information, consumption behaviour, group and China market. Our study revealed the shift in luxury consumption towards affordability, availability, middle-class, younger consumers and predominantly Asian markets.Research limitations/implicationsAs a follow-up to this research, empirical research on luxury wine consumption is needed to establish more precise definitions of terms.Social implicationsWine as a product is susceptible to social changes and preferences, positioning it between old and common luxury.Originality/valueThis research offers theoretical insights into research on luxury wine, including how the literature reflects recent societal changes. It also provides a roadmap for future research in this field.
How much does regional bias affect China's regional agricultural trade?
Authors: Jia Wei , Nuetah J. Alexander 
Published: April 2022

PurposeMarket integration in China is still progressing, while the border effects of trade among regions still exist. The question of whether eliminating or weakening regional bias can promote of China's agricultural trade still remains an important issue. This paper analyzes the impact of regional bias on China's agricultural trade.Design/methodology/approachThis paper constructs a pure exchange computable general equilibrium model of nine regions and three sectors, and analyzes the impact of regional bias on China's regional agricultural trade; Comparing the differences of regional bias on China's inter-regional and external agricultural trade, the paper especially analyzes the impact of the agricultural imports and exports in eight regions of China.FindingsThe results show that regional bias has had substantial impacts on China's agricultural trade. Elimination of regional bias would therefore increase China's agricultural exports and imports by factors of 1.32 and 1.63, respectively while its agricultural trade deficit would increase by 84%. Inter-regional agricultural trade in China would increase by 3.53 times. With the elimination of regional bias, the Northern coastal, Central and Northwestern regions would have the largest increase in inter-regional agricultural trade. Unlike the Northern coastal region, inter-regional agricultural import in the Central and Northwestern regions tends to be greater than inter-regional agricultural exports.Originality/valueThis paper thus aims to fill existing gap in investigating the impacts of regional bias on China's agricultural trade. Firstly, the model proposed in this paper does not only consider the linkage between the agricultural and non-agricultural sectors, but also the inter-regional agricultural trade linkages of the different regions in China. Secondly, the authors decompose home bias into national and regional biases and assess how regional bias affects agricultural trade of the various regions of China.
Barriers to stakeholder engagement in sustainable procurement of public works
Authors: Agyekum Amma Kyewaa , Fugar Frank Desmond Kofi , Agyekum Kofi , Akomea-Frimpong Isaac , Pittri Hayford 
Published: April 2022

PurposeThe absence of effective stakeholder engagement at the early planning and implementation stages impact projects negatively. However, the role of stakeholders in Sustainable Procurement (SP) is not well recognized and as such there is limited involvement of stakeholders in sustainable procurement of public (SPP) works. This research aims to examine the barriers to stakeholder engagement in SPP works.Design/methodology/approachA survey of 104 respondents from eight procurement entities of tertiary institutions in Ghana was undertaken and validated with seven procurement experts. After satisfying all the necessary tests of reliability of the survey instrument and sample size, the data was subjected to the Principal Component Analysis (PCA) to determine the critical barriers.FindingsThe study's results indicate that there are three cluster of barriers to stakeholder engagement in SPP works. They are organisational structures and knowledge driven factors, attitudinal and stakeholder fatigue and relational and information sharing processes.Practical implicationsThis study offers relevant data for policy makers, organisations and local communities in establishing controls against barriers to stakeholder engagement. Furthermore, this research presents policy makers with recommendations to improve communication and organisational policies in enhancing stakeholder participation in SPP works in Ghana and other developing countries.Originality/valueAlthough studies on SP has increased with time, issues such as obstacles to stakeholder engagement in SP remain unexplored. Empirical data presented in this study bridges the gap that exists on the barriers of stakeholder engagement in SPP works in the Ghana Construction Industry.
Bargaining optimization model for risk renegotiation with fairness concerns in infrastructure PPP projects
Authors: Chen Canjun , Lv Lelin , Wang Zhuofu , Qiao Ran 
Published: April 2022

PurposeReasonable risk sharing is the key to the smooth implementation of infrastructure public-private partnership (PPP) projects and the optimization of benefit distribution among the participants. This study aims to explore the risk redistribution ratio between the government and the private sector under different degree of fairness concern.Design/methodology/approachRenegotiation is a mechanism to provide flexibility and make up for incompleteness of PPP contracts. However, the threshold value of risk redistribution ratio and negotiation cost are not explicitly considered in previous studies. In addition, these studies do not consider the influence of the fairness concern psychology on the negotiation process. To address these gaps, based on risk-income equilibrium analysis, this paper established the bargaining optimization model of PPP projects renegotiation considering the fairness concerns of the negotiating parties. Furthermore, this study analyzed the influence of fairness concern degree on negotiation thresholds, negotiation results, and negotiation incomes under three scenarios.FindingsThe results showed that excessive focus on the fairness of incomes may exclude the risk redistribution ratio that is most beneficial to project incomes from the negotiation threshold. Moreover, the increase in the fairness concerns of negotiating parties can reduce the negotiation success period, but the net income may not necessarily be improved.Originality/valueThe main contribution of this paper is to propose a new risk renegotiation methodology based on the risk-income equilibrium analysis, which is helpful to develop risk management strategies in the construction field. The research results can provide government with reference about renegotiation in decision making and provide theoretical support for the practice of PPP renegotiation.