bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging of pediatric pancreas tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper
Authors: Eklund Meryle J. , States Lisa J. , Acord Michael R. , Alazraki Adina L. , Behr Gerald G. , El‐Ali Alexander M. , Morin Cara E. , Saigal Gaurav , Shet Narendra S. , Thacker Paul G. , Trout Andrew T. 
Published: October 2022

AbstractPrimary pancreatic tumors in children are rare with an overall age‐adjusted incidence of 0.018 new cases per 100,000 pediatric patients. The most prevalent histologic type is the solid pseudopapillary neoplasm, followed by pancreatoblastoma. This paper describes relevant imaging modalities and presents consensus‐based recommendations for imaging at diagnosis and follow‐up.
Phase 1b study of carfilzomib with induction chemotherapy in pediatric relapsed/refractory acute lymphoblastic leukemia
Authors: Burke Michael J. , Ziegler David S. , Bautista Francisco , Attarbaschi Andishe , Gore Lia , Locatelli Franco , M. O'Brien Maureen , Pauly Melinda , Kormany William N. , Tian Shengqi , Morris Christopher L. , Baruchel Andre 
Published: October 2022

AbstractBackgroundAcute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in childhood. Survival for patients following relapse remains poor, and achieving complete remission (CR) after relapse is the first critical step to cure. Carfilzomib is a proteasome inhibitor with an acceptable safety profile and clinical activity in adults with multiple myeloma but has not been assessed in children. The primary objective of this phase 1b study was to assess the safety and tolerability of carfilzomib combined with vincristine, dexamethasone, asparaginase, and daunorubicin (VXLD) in children with relapsed and/or refractory ALL.MethodsPatients aged 1–21 years (n = 24) received 4‐week induction therapy with carfilzomib at dose levels of 27 mg/m2 (n = 3), 36 mg/m2 (n = 7), 45 mg/m2 (n = 4), and 56 mg/m2 (n = 10) in combination with VXLD. Patients achieving stable disease were offered further consolidation chemotherapy. Analyses were based on the safety evaluable population.ResultsFollowing dose escalation of carfilzomib, the recommended phase 2 carfilzomib dose was identified as 56 mg/m2. Grade ≥3 hematological adverse events were common (83%, 20/24 patients), and serious treatment‐emergent adverse events occurred in 58% (14/24) of patients. At the end of induction, CR/CR with incomplete platelet recovery (CRp)/CR with incomplete blood count recovery (CRi) was identified in 50% of patients (n = 12/24). By the end of consolidation, cumulative CR/CRp/CRi was identified in 58% of patients (n = 14/24).ConclusionThese data support the use of carfilzomib in pediatric patients with relapsed and/or refractory ALL.
Centralized/decentralized indirect robust adaptive control for spacecraft attitude and robotics
Authors: Rivolta Aureliano , Lunghi Paolo 
Published: October 2022

AbstractThe diffuse presence of robotic subsystems in new space mission concepts introduces variations and uncertainties in system mass and inertia, imposing stringent constraints to orbital and attitude control. The required performance can be achieved through several paradigms like robust or adaptive controllers and sometimes a combination of the two. In this work, a novel indirect controller, belonging to the robust‐adaptive controllers class, is developed, with the core idea of requiring just one adaptive gain with consequent lower sensitivity and easier tunability. The algorithm is developed both in centralized and decentralized formulation and tested for reliability and parameter sensitivity.
Perceptions of political Self‐Dealing? An empirical investigation of market returns surrounding the disclosure of politician stock purchases
Authors: Abdurakhmonov Mirzokhidjon , Snider Roary E. , Ridge Jason W. , Hasija Dinesh 
Published: October 2022

AbstractResearch summaryWe investigate how congressional stock purchases may impact investor expectations of firm outcomes. Specifically, we argue that because there is information asymmetry regarding how public policy may impact a firm and investors perceive that members of the U.S. Congress possess insider governmental information and power over the regulatory landscape of a firm, a legislator's purchase of firm stock will generate abnormal returns. Furthermore, we argue that this response will be greater if the Congressperson has jurisdiction over the firm through committee assignments, and that the effect of jurisdiction will be strongest when the firm ties itself directly to the politician through political strategies (e.g., lobbying sponsored legislation, committee testimony, and political action committee contributions). We find support for many of our arguments in a broad sample of senator stock purchases between 2012 and 2020.Managerial summaryWe examine stock purchases of the members of the U.S. Senate for years 2012–2020 and find that stock purchases by senate members generate abnormal returns. We also find that abnormal returns are higher if the senator has direct jurisdiction over the firm through committee assignments. We see an increase in abnormal returns if the firm is tied to the member of the U.S. Senate through lobbying‐sponsored legislation and political action committee contributions. We also find that stocks both purchased and sold by senators experience negative abnormal returns over the 6–12 months following the transaction date. Our study provides insights into important public policy questions related to transparency and ethics in government and speaks to the question of investments by public servants.
Impact of slip boundaries on double diffusivity convection in an asymmetric channel with magneto‐tangent hyperbolic nanofluid with peristaltic flow
Authors: Saeed Khalid , Akram Safia , Ahmad Adeel , Athar Maria , Razia Alia , Muhammad Taseer 
Published: October 2022

AbstractThe impact of slip boundaries on velocity, thermal and concentration convection in a magneto‐tangent hyperbolic nanofluid coated with peristaltic flow is the objective of this article. The magneto‐tangent hyperbolic nanofluid flow equations are mathematically defined in detail. The purpose problem is simplified under creeping flow and long wavelength assumptions. The analysis is performed under slip boundary conditions. The extremely non‐linear equations are solved using a numerical technique. The significance of important physical parameters of relevance is graphically illustrated for Weissenberg number, Hartmann number, thermophoresis parameter, power law index, Brownian motion, Soret and Dufour diffusively parameters. It is noted that temperature profile rises because of the growing influence of thermal slip, but concentration falls as a result of rising concentration slip parameter.
Introduction into the Overall Message of the Book: Destruction of Heritage Is Destroying Identity – Shared Responsibility Is Therefore Our Common Task for the Future
Authors: Albert Marie-Theres , Bernecker Roland , Cave Claire , Prodan Anca Claudia , Ripp Matthias 
Published: October 2022

AbstractThe Introduction to the book “50 Years World Heritage Convention: Shared Responsibility – Conflict & Reconciliation” sets the stage by presenting the key message, background and content of the book. The identity-building function of heritage and its sustainable protection assume a central role. Accordingly, the chapter provides an overview of policy tools and academic debates engaging with this matter, while emphasizing the critical issues undertaken with the volume at hand. These are to reflect on whether the goals and content of the World Heritage Convention have been implemented accordingly; on the conflicts that have been affecting it over time and the need for sustainable strategies; and on perspectives for the future. This chapter further emphasises the requirements for diversity, arising from the World Heritage Convention and the variety of heritage properties, and it is reflected in the thematic, geographic and disciplinary diversity of the contributions in this book. For illustration, the chapter provides brief descriptions of conflicts affecting heritage, categorized into six areas, as well as summaries of the chapters which address them.
UNESCO World Heritage and Cultural Property Protection in the Event of Armed Conflict
Authors: Schipper Friedrich 
Published: October 2022

AbstractBamiyan, Palmyra, Timbuktu are examples of iconic toponyms of ancient civilization that have been used as headlines in international media coverage of the Islamist extremists’ war – including the Taliban, Daesh, and Ansar Dine – against World Cultural Heritage as listed by UNESCO. Further, more sites are being inscribed on UNESCO’s list ofWorld Heritage in Dangeror referred to in the reports of ICOMOS’Heritage at Risk programmebecause of the imminent threat posed by current armed conflict, for example, in Afghanistan, Armenia and Azerbaijan, Iraq, Libya, Mali, Syria, Yemen, and other countries struck by war or the violent consequences of political instability. Nowadays, war, terrorism, vandalism, and iconoclasm pose an equal threat to cultural heritage. This poses a series of questions to heritage as well as conflict studies.
Palmyra: Bridging Past and Future
Authors: Elcheikh Zeina 
Published: October 2022

AbstractTargeting and destroying Syria’s cultural heritage have become a common concern, especially in the case of Palmyra. The ruined city enjoyed a significant position in the country’s history and bore a large share of the violence in Syria’s protracted tragedy. Since 2014, militants of ISIS (Islamic State in Iraq and Syria) have committed many acts of terrorism, claiming thousands of lives and shattering others, looting antiquities and destroying historic sites, including World Heritage sites. In 2015, ISIS extremists destroyed Palmyra’s major monuments, and, since then, this destruction has been the focus of debates on the academic and professional levels and in the media. This chapter has two parts. The first part briefly reviews Palmyra’s long history, in which monuments have been subject to selective narratives and official instrumentalisation. The second part looks at the current debates on Palmyra’s heritage loss in the light of the actual conflict, in which the local community has been unheeded. This chapter suggests that future efforts need to (re)consider the role of local communities in heritage debates and the right(s) to their heritage to bridge the discontinuity between the past and the future caused by the terrorism and conflict.
Change in Water Technology in Anatolia: From Use to Energy, Conflicts to Climate Action
Authors: Erkan Yonca 
Published: October 2022

AbstractUNESCO World Heritage properties in Anatolia show a great variety in their land use morphologies as a response to their environmental differences, developing different ways of managing water for daily use and agricultural irrigation. History testifies to the many conflicts and wars that occurred in defending and/or accessing these important water resources. The remnants of this infrastructure form part of invaluable cultural heritage and present opportunities for the embodied traditional knowledge to mitigate the impacts of climate change. However, ruthless water regimes (i.e. hydroelectric plants), which disregard the importance of water for communities, have prioritized water as a source of energy over its value for daily and agricultural use and have impacted the environment and climate, which directly affects both tangible and intangible cultural heritage. Dried creeks leave water-related infrastructure and equipment without a purpose and people deprived of water. In the age of Anthropocene, such an approach victimizes people through the idea of taking over nature while at the same time making people the victims of nature’s response. In return, new regional conflicts are instigated, and migration becomes inevitable, diminishing neighbourly peace and also aggravating climate change, causing negative impacts on cultural heritage and jeopardising many of the UN Sustainable Development Goals.
Mineral Extractive Industries in the Context of European World Heritage Cultural Landscape Conservation and Management: The Case Study of the Erzgebirge/Krušnohoří Mining Region
Authors: Hansell Friederike 
Published: October 2022

AbstractCurrent prospection activities lead not only to the opening of new mines but also to a revival of activity in historic mining areas that are partly in or close to protected areas. Consequently, the issue of mining and its potential negative impact on protected areas, including natural World Heritage sites in particular, has increased over the past two decades. Considering that attributes and values assigned to natural World Heritage sites differ from those assigned to cultural World Heritage sites, the paper focuses on the evaluation of the potential impact of mining activities on cultural World Heritage sites and outlines management and conservation strategies as well as recommendations for the assessment of potential negative and positive impacts of mining activities on the OUV.
Adopting Digital Tools & Technology to Evolve Sustainable Tourism at World Heritage Sites: Case Studies from India and Greece
Authors: Zaimes George N. , Iakovoglou Valasia , Maclaren Fergus T. , Manchanda Pankaj 
Published: October 2022

AbstractThere is a strong interconnection between tourism and World Heritage Sites. This interconnection, on the one hand, can have a positive impact by presenting these sites to the public and helping generate conservation funds, but, on the other hand, if done unsustainably, can lead to their degradation. The adoption of digital technologies in tourism has made travel and visitations, even in remote areas, relatively easy. The adoption of new technologies at World Heritage Sites can also prove to be beneficial and help evolve a more sustainable tourism model at these venues. Furthermore, the new conditions due to the COVID-19 pandemic, while having a detrimental impact on global tourism, provide an opportunity to remotely promote and generate revenue to preserve a regions’ tangible and intangible heritage. A technology-based intervention, if adopted correctly, can help to develop sustainable visitation capacity and management at World Heritage Sites while also enhancing and enticing visitation at lesser-known sites. Case studies from Greece and India are presented to demonstrate how to increase visitation to lesser-known sites and enhance the overall tourism experience at these sites. A variety of digital tools are presented, from simplistic to technologically advanced ones. These digital tools could be adopted and used globally for other World Heritage Sites to enhance visibility and sustainability.
Natural Heritage in Danger. Native Forests, New and Old Forms of Extractive Activities and Sustainability from the Perspective of a New Generation of Scientists, Activists and Entrepreneurs in Argentina
Authors: Lozano Claudia 
Published: October 2022

AbstractThis article aims to address conflictive projects and their pathways of resolution in the field of land use and territorial and natural resource management in Latin America in relation to one of the protected areas of Argentinean Patagonia, Los Alerces National Park (PNLA), inscribed by UNESCO as a Natural World Heritage Site in 2017. I argue that the changes driven by the commodity boom (2000–2014), i.e., the development of extractive activities, deforestation and the expansion of grain and mineral exports, have had and continue to have a high environmental impact. Since the 2000s, the continent has experienced a series of protests that brought to light the unease caused by projects based on the development of large-scale extractive activities, which impacted legislation and reinforced the implementation of restrictive regulations for territorial management and land use, as seen from the nomination of the PNLA as a Natural World Heritage Site. The article shows that the legislative changes, as well as requirements of the PNLA inscription, provide fundamental legal support to the formulation, management and technical implementation of a new agro-silvo-pastoral culture capable of reconciling the conservation of scenic value (vii), biodiversity (x) and sustainability in protected areas. This proposal opens up the possibility of expanding the protected areas within the framework of the Andean-North Patagonian Biosphere Reserve.
Sustainability – A Guiding Principle of the World Heritage Convention – What Has Been Achieved – What Is Missing – What Is the Future Perspective
Authors: Fuhrmann Constanze 
Published: October 2022

AbstractThe World Heritage Convention (WHC), as the premier charter for heritage protection, has long adopted sustainability as a core principle. With today’s understanding of heritage management as an important driver of economic growth, social capital and environmental protection, its reconciliation with sustainable practices is inevitable. Fifty years on, the WHC faces new challenges concerning promoting and supporting sustainable development. With the broad adoption of SDGs, heritage actors working under the WHC framework frequently encounter conflicting objectives. While in theory, the social, ecological and economic dimensions of sustainable development can be reconciled, in practice, this often requires finding viable and balanced trade-offs. The growing awareness for climate change in the last ten years results in the need to reprioritise the different dimensions and can lead to hard choices that have been framed as dilemma situations. This paper takes a closer look at those dilemma situations and discusses how the WHC can help tackle these and make the right decisions in the face of complex sustainability choices.
Urban Transformation and Related Conflicts at UNESCO World Heritage Sites
Authors: Gustafsson Christer , Ripp Matthias 
Published: October 2022

AbstractCities are constantly changing. Today, policy-makers all over the world are discussing how to create the conditions for developing green, healthy and safe cities where people meet and innovations are created. There is a great need to change to a climate-smart society with people at the centre. Urban cultural heritage is also constantly changing; however, the World Heritage Convention and its tools take their starting points in the preservation of monuments and ensembles. This introduction to section four presents the emerging scientific concept of urban transformation, relates it to conflicts at UNESCO World Heritage Sites (WHS) and discusses possible ways forward in the overall frame of this book.
Going Beyond Tourism Attraction in the Festivalisation of World Heritage Cities
Authors: Jones Zachary M. 
Published: October 2022

AbstractTourism has long been noted as a double-edged sword for World Heritage cities that can lead to a wide range of socio-economic benefits while also introducing many stresses that both physically damage sites and affect local communities through gentrification and other socio-economic changes. Festivals, events and cultural mega-events are often framed with a focus on growing tourism, but they can also provide unique opportunities to align heritage with Sustainable Development Goals. This chapter explores these dynamics by looking at three trends that the festivalisation of heritage cities can lead to: establishing and promoting heritage-based city images; spreading out events to reduce stresses; expanding traditional definitions of heritage through involving local communities. Several examples from across Europe that have hosted the Expo, European Capital of Culture (ECoC) and the UK City of Culture (UKCoC) demonstrate varying alignments with the Historic Urban Landscape (HUL) approach, Sustainable Development Goals (SDGs) and the UNESCO 5Cs to promote the sustainable development and inclusion of historic environments in broader city strategies. The chapter concludes by calling for a more integrated governance approach that can reframe approaches to go beyond just tourism attraction while anticipating and avoiding the potential range of risks of festivalisation.
Pulse Oximetry: The Working Principle, Signal Formation, and Applications
Authors: Leppänen Timo , Kainulainen Samu , Korkalainen Henri , Sillanmäki Saara , Kulkas Antti , Töyräs Juha , Nikkonen Sami 
Published: October 2022

AbstractPulse oximeters are routinely used in various medical-grade and consumer-grade applications. They can be used to estimate, for example, blood oxygen saturation, autonomic nervous system activity and cardiac function, blood pressure, sleep quality, and recovery through the recording of photoplethysmography signal. Medical-grade devices often record red and infra-red light-based photoplethysmography signals while smartwatches and other consumer-grade devices usually rely on a green light. At its simplest, a pulse oximeter can consist of one or two photodiodes and a photodetector attached, for example, a fingertip or earlobe. These sensors are used to record light absorption in a medium as a function of time. This time-varying absorption information is used to form a photoplethysmography signal. In this chapter, we discuss the working principles of pulse oximeters and the formation of the photoplethysmography signal. We will further discuss the advantages and disadvantages of pulse oximeters, which kind of applications exist in the medical field, and how pulse oximeters are utilized in daily health monitoring.
A Diffractive Reading
Authors: Engman Mel , Ennser-Kananen Johanna , Saarinen Taina 
Published: October 2022

AbstractTowards the end of the editing process, we started to see the book as something more than a collection of chapters around a theme: as an assemblage, which included, of course, the community of authors. When we put out the first call for contributions in May 2018, most authors volunteered a contribution rather quickly, others joined a bit later, and some dropped out for different reasons, underlining the dynamic nature of our assemblage. In pre-pandemic times, we met on and off campus, introduced some of our ideas at conferences, and had a workshop day to brainstorm, plan chapters, and reflect on the process and the purpose of the book. We were connected by common meals, jokes, writing, thinking, and by annoying and challenging each other as colleagues and collaborators. Sometimes, we managed to give space to the other lives we lead: our families, homes, and hobbies. We are thankful that these were invited into our work and being-together. This chapter provides a concluding diffraction, not only as a metaphor of a prism that collects and reconfigures our varied ideas, but as a socio-material view into the book process itself.
“I Have Karelia in My Soul” – Intra-action of Students, Seniors and Artefacts in a Community-Engaged Service-Learning Collaboration
Authors: Muhonen Anu , Vaarala Heidi 
Published: October 2022

AbstractIn this chapter we examine a foreign language learning environment in a community-engaged setting in a Canadian city through a new materialist lens. As part of a service-learning project, Canadian students of Finnish language and culture visit a Finnish language seniors’ centre regularly to participate in different activities and spend time with the Finnish-speaking seniors. We examine the assemblage of the participants (seniors and students) and one artefact, a map, and offer a close analysis of the intra-action that takes place during one visit at the centre. In our analysis, our service-learning collaboration does not merely give a voice and agency to seniors. Rather, the seniors actively take the opportunity to voice their knowledge, and doing that, give a voice to an old Finnish school map, which retells stories of the seniors’ past in intra-action. Meanwhile the students also gain new knowledge.