bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth performance and heamatobiochemical parameters of broilers fed diets containing Artemisia afra essential oil
Authors: Zvarivadza William , Marume Upenyu 
Published: April 2022

The study was conducted to determine the effects of Artemisia afra Jacq. ex Willd. essential oil inclusion in diets on growth performance and blood parameters in broiler chickens. Four hundred day-old Cobb 500 chicks were randomly allotted to four treatments: NC – negative control (commercial broiler diet without antibiotics), PC – positive control (commercial broiler diet), AA1 – commercial diet + 0.1% A. afra essential oil, and AA2 – commercial diet + 0.3 % A. afra essential oil. Each treatment was replicated 10 times. From the results, birds fed the PC diet had the highest average daily feed intake (105.60 g ± 3.18) and average daily gain (ADG) in the grower phase. The highest ADG in the finisher phase was obtained in the AAI treatment (170.23 g·d−1 ± 2.00), whereas the feed conversion ratio was lower in the essential-oil-containing diets. Diet significantly improved protein utilization efficiency in both grower and finisher phases. Birds fed AA1 had the highest values for neutrophils, monocytes, and eosinophils, whereas those fed the NC diet had the highest alkaline phosphatase levels (102.00 IU·L−1 ± 7.61). The findings of the study suggest the use of A. afra essential oil in broiler diets can positively improve growth and flock health.
Response of alewife abundance to the bacterial kidney disease outbreak in the Chinook salmon population of Lake Michigan: importance of predation
Authors: Madenjian Charles P. 
Published: April 2022

Prey fish abundance can be influenced by predation (top-down) and food limitation (bottom-up) effects. I characterized temporal trends in yearling and older (YAO) alewife (Alosa pseudoharengus) biomass density, as estimated by a long-term bottom trawl survey, in Lake Michigan during 1973–2019. Special attention was given to the bacterial kidney disease (BKD) outbreak in the population of Chinook salmon (Oncorhynchus tshawytscha), the predominant predator on alewives in the lake. YAO alewife biomass density exhibited a steep and significant decline during 1973–1985, but then partially rebounded with a significant increase between the 1983–1985 and 1986–2003 (BKD years) periods, followed by a significant decrease between the 1986–2003 and 2004–2006 periods. YAO alewife biomass density showed another significant decline during 2004–2019. The BKD outbreak led to a partial relaxation of predation on the YAO alewife population, and YAO alewife biomass density responded by showing a moderate increase in 1986 and then fluctuating about this moderately higher level for more than 15 years. Overall, temporal trends in YAO alewife biomass density were primarily driven by predation.
Insight into the microscopic structure of a quintessential black hole from the quantization concept
Authors: Aounallah H. , El Moumni H. , Khalloufi J. , Masmar K. 
Published: April 2022

In this work, based on [D.-Q. Sun, J.-B. Deng, P. Li and X.-R. Hu, Class. Quantum Grav. 37, 015008 (2020)], we examine the effect of the quintessence field on the microscopic structure of a charged anti-de Sitter (AdS) black hole from the quantization perspective. Indeed, the impact of the state parameter and the quintessence intensity on “energy quantum” is illustrated. Furthermore, we extend the relationship between the number of quanta of the area and the microscopic degrees of freedom of the black hole to the quintessential background. We express the latent heat in terms of the number of quanta of the area of the large black hole (LBH) and the number of quanta of the area of the small black hole (SBH). Besides that, we explore the connection between the microscopic structure and Ruppeiner geothermodynamics in the (mass, pressure)-plane through the number of quanta of area perspective and the quintessence parameters. Finally, we interpret our result in terms of repulsive/attractive interactions amongst the black hole constituents.
Safety and Efficacy of Engineered Toxin Body MT-3724 in Relapsed or Refractory B-cell Non-Hodgkin's Lymphomas and Diffuse Large B-cell Lymphoma
Authors: Hamlin Paul A. , Musteata Vasile , Park Steven I. , Burnett Christine , Dabovic Kristina , Strack Thomas , Williams Eric T. , Anand Banmeet S. , Higgins Jack P. , Persky Daniel O. 
Published: April 2022

MT-3724, a novel engineered toxin body comprised of an anti-CD20 single-chain variable fragment genetically fused to Shiga-like Toxin A subunit, is capable of binding to and internalizing against CD20, inducing cell killing via permanent ribosomal inactivation. This study evaluated MT-3724 in patients with relapsed/refractory B-cell non-Hodgkin lymphoma (r/rNHL). This open-label, multiple-dose phase Ia/b trial included a dose escalation in patients with r/rNHL according to a standard 3+3 design. Primary objectives were to determine the MTD and pharmacokinetics/pharmacodynamics. In a dose expansion study at MTD in serum rituximab-negative patients with diffuse large B-cell lymphoma (DLBCL), primary objectives were safety, tolerability, and pharmacokinetics/pharmacodynamics. Twenty-seven patients enrolled. MTD was 50 μg/kg/dose with 6,000 μg/dose cap. Thirteen patients experienced at least one grade ≥3 treatment-related adverse events; the most common grade ≥3 event was myalgia (11.1%). Two patients (75 μg/kg/dose) experienced grade 2 treatment-related capillary leak syndrome. Overall objective response rate was 21.7%. In serum rituximab-negative patients with DLBCL or composite DLBCL (n = 12), overall response rate was 41.7% (complete response, n = 2; partial response, n = 3). In patients with detectable baseline peripheral B cells, treatment resulted in dose-dependent B-cell depletion. The proportion of patients with anti-drug antibodies (ADA) increased during treatment and the majority appeared to be neutralizing based on an in vitro assay; nevertheless, tumor regression and responses were observed. MT-3724 demonstrated efficacy at the MTD in this population of previously treated patients with r/rDLBCL, with mild-to-moderate immunogenic safety events.Significance:This work describes the safety and efficacy of a new pharmaceutical pathway that could provide a treatment option for a subset of patients with a critical unmet therapeutic need. The study drug, MT-3724, is capable of targeting B-cell lymphomas via a unique, potent cell-killing mechanism that appears to be promising.
The confirmation of scientific theories using Bayesian causal networks and citation sentiments
Authors: Small Henry 
Published: April 2022

Abstract
The confirmation of scientific theories is approached by combining Bayesian probabilistic methods, in particular Bayesian causal networks, and the analysis of citing sentences for highly cited papers. It is assumed that causes and their effects can be identified by linguistic methods from the citing sentences and that the cause-and-effect pairs can be equated with theories and their evidence. Further, it is proposed that citation context sentiments for “evidence” and “uncertainty” can be used to supply the required conditional probabilities for Bayesian analysis where data is drawn from citing sentences for highly cited papers from various fields. Hence, the approach combines citation and linguistic methods in a probabilistic framework and, given the small sample of papers, should be considered a feasibility study. Special attention is given to the case of nociception in medicine, and analogies are drawn with various episodes from the history of science, such as the Watson and Crick discovery of the structure of DNA and other discoveries where a striking and improbable fit between theory and evidence leads to a sense of confirmation.
Vegetation Greening, Extended Growing Seasons, and Temperature Feedbacks in Warming Temperate Grasslands of China
Authors: Shen Xiangjin , Liu Binhui , Henderson Mark , Wang Lei , Jiang Ming , Lu Xianguo 
Published: April 2022

Abstract
Vegetation activity and phenology are significantly affected by climate change, and changes in vegetation activity and phenology can in turn affect regional or global climate patterns. As one of the world’s great biomes, temperate grasslands have undergone remarkable changes in recent decades, but the connections between vegetation activity and phenology changes and regional climate there have remained unclear. Using the observation minus reanalysis (OMR) method, this study investigated the possible effects of vegetation activity and vegetation growing season changes on air temperatures in temperate grasslands of China. The results showed that average NDVI of the temperate grassland significantly increased by 0.011 decade−1 for the growing season during 1982–2015. The growing season started earlier and ended later, resulting in an extension. Increased vegetation activity during spring and autumn significantly warmed spring and autumn air temperatures by reducing albedo. By contrast, summer greening had no significant effect on summer temperature, due to the opposing effects of decreased albedo and enhanced evapotranspiration on temperature. The earlier start and later end of the growing season contributed to warmer spring and autumn air temperatures. As phenological changes had no significant effect on summer temperature, the extended growing season warmed air temperature. Our results suggest that the climate change–induced increasing vegetation activity and extended growing seasons can further aggravate regional warming in temperate grasslands of China, implying that the effects of vegetation activity and phenology changes on regional climate should be considered in climate models for accurately simulating climate change in temperate grasslands.
Serum Uric Acid to Albumin Ratio Can Predict Contrast-Induced Nephropathy in ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
Authors: Şaylık Faysal , Çınar Tufan , Akbulut Tayyar , Selçuk Murat 
Published: April 2022

Contrast-induced nephropathy (CIN) is one of the common complication of ST-elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (pPCI). Serum uric acid to albumin ratio (UAR) is a novel marker, which is associated with acute kidney injury in intensive care unit patients. We investigated the predictive value of UAR for the development of CIN in STEMI patients (n = 1379) after pPCI. The diagnosis of CIN was made based on an increase of basal creatinine levels >.5 mg/dL or 25% within 72 h after pPCI; 128 patients were in the CIN (+) group and 1251 patients were in the CIN (−) group. CIN (+) patients had higher serum uric acid (SUA), UAR, and lower albumin levels than CIN (−) patients. Age, diabetes, hypertension, hemoglobin, glucose at admission, basal creatinine, peak troponin I, total bilirubin, contrast volume/glomerular filtration rate, and UAR were independent predictors of CIN. A cutoff value of 1.62 for UAR detected CIN development with a sensitivity of 54% and specificity of 87.4%, and the discrimination ability of UAR was better than that of SUA or albumin. In conclusion, UAR was an independent predictor of the development of CIN.
Efficacy of Cochlear Implantation in Neurofibromatosis Type 2 Related Hearing Loss
Authors: Sobczak Gabriel , Marchant Wendy , Misurelli Sara , Pyle Garrold Mark , Gubbels Samuel , Roche Joseph 
Published: April 2022

Objective: To investigate the results of cochlear implantation in subjects with neurofibromatosis type 2 (NF2) and bilateral vestibular schwannomas (VS). Study Design: Retrospective case series. Setting: University-based tertiary referral center. Subjects: Five subjects with NF2 and severe-to-profound sensorineural hearing loss. Intervention: Cochlear implantation. Main Outcome Measure: Surgical outcomes and audiometric performance after cochlear implantation. Results: Five subjects (3 female, 2 male) were included in the study. The mean age at the time of implantation was 54 years old (range 35-78 years). Follow-up after cochlear implantation averaged 38 months (range 21-106 months). In the 5 implanted ears, 2 had no prior treatment, 1 had undergone prior radiation therapy, 1 underwent prior microsurgical removal, and 1 underwent prior microsurgical removal with adjuvant radiation therapy. The mean ipsilateral VS dimensions at time of implantation were 14 mm × 7.2 mm × 6.1 mm (mediolateral × anteroposterior × craniocaudal). Following cochlear implant activation, all 5 subjects achieved sound awareness, open set speech recognition, and 4 continue to be daily users of the devices. Conclusion: Cochlear implantation is a viable hearing rehabilitation option for subjects with NF2 and severe-to-profound sensorineural hearing loss. All subjects reported benefit with their cochlear implant, including open set speech recognition, enhanced lip-reading skills and environmental awareness of sound. Four subjects continued to demonstrate improved open-set speech recognition at the time of their last evaluations.
Microstructure and mechanical properties of FSW medium thickness 2219 aluminum alloy
Authors: Lu Xiaohong , Meng Xiangyue , Ma Chong , Sun Shixuan , Liang Steven Y 
Published: April 2022

To achieve high-quality friction stir welding (FSW) of the rocket fuel tank, experiments of FSW 18 mm thick 2219 aluminum alloy are carried out, the microstructure and mechanical properties of the joints are studied, and the influence law of the tool rotation speed on microstructure, microhardness and tensile strength of the welded joints are explored. The welding speed used in the experiment is 100 mm/min, and the tool rotation speed is 350 r/min, 400 r/min and 450 r/min, respectively. The microstructure of the weldments is analyzed by optical microscopy and scanning electron microscopy. The mechanical properties are measured by tensile tests and Brinell hardness, and it is found that the mechanical properties of the joint first increased and then decreased with the increase of the tool rotation speed. Due to the uneven temperature distribution along the thickness direction of the weldment, the crystal grains in the nugget zone (NZ) are small equiaxed crystals as a whole, with different local sizes and shapes. The size of the crystal grains seems relatively large in the upper layer and relatively small in the bottom layer. As the tool rotation speed increases, so does the heat generation, and thus, the size and degree of the deformation of the crystal grains increase. The defect appears when the tool rotation speed is 450r/min. As the tool rotation speed increases, the tensile strength and microhardness of the joints increase first and then decrease. The maximum tensile strength of the overall weld is 270 MPa. The microhardness shows a trend of ‘‘U’’ distribution, and the hardness in the NZ is slightly higher than that of thermos-mechanically affected zone (TMAZ) and heat-affected zone (HAZ). The fracture location of the joints is the NZ. The fracture mode is ductile fracture. There exist a large number of second phase particles Al2Cu in the dimples.
Choroidal granulomas due to Bartonella henselae infection: A case series
Authors: Gattoussi Sarra , Romdhane Bouchra B. , Seneclauze Arnaud , Rougier MB , Korobelnik JF 
Published: April 2022

Purpose To report a case series of 3 patients with choroidal granulomas due to Bartonella henselae infection in order to raise awareness about this etiology in the differential diagnosis of choroidal granulomas. Methods, patients A retrospective case series of patients with choroidal granulomas due to Bartonella henselae infection who consulted between 2018 and 2020. Data were collected from the medical records (demographics, visual acuity (VA), laboratory tests, treatment, imaging). Results Patients were a 48-year old man, a 14-year old girl and a 31-year old man. They all had a choroidal granuloma seen on optical coherence tomography (OCT) and angiography. The laboratory work-up revealed a positive serology for Bartonella henselae in all patients. Conclusion On multimodal imaging choroidal granulomas in B Henselae appeared as single or multiple, uni or bilateral round yellowish lesions. Fluorescein and indocyanine green angiography of the granuloma showed respectively a late staining and a hypofluorescence. On EDI-OCT choroidal granuloma appeared as a round hyporeflective lesion in the choroid with a retinal elevation. The exclusion of other diagnosis, the natural course and the serology must lead the ophthalmologist to evoke the diagnosis.
Large bilateral medial rectus recession versus three-to-four horizontal muscle surgery for large-angle esodeviations
Authors: Torrefranca Aramis B. , Santiago, Alvina Pauline D. 
Published: April 2022

Purpose The best surgical approach to correcting large angle esodeviations is still debated. Options for correcting large esodeviations include recessing both medial rectus (BMR) muscles more than 5.5 mm or performing surgery on three or four horizontal rectus muscles. There remains no consensus on which surgery has better survival outcomes. In this research, we are interested in determining the survival rates and long-term outcomes of both surgeries locally in the Philippines. Results A total of 74 medical records were retrospectively reviewed. The mean age at onset of deviation was 2  ±  2.9 years old, and the mean age at surgery was 14  ±  12.5 years, with a mean of 12  ±  12.1 years from onset to surgery. The mean follow-up period was 9.9 months (range 6–24) . The mean preoperative deviation at near was 59.3  ±  13.6 PD (range: 35–95) while at distance was 58.5  ±  13.6 PD (range 10–95). The most common type of esotropia (ET) was infantile ET (45%), followed by basic ET. Majority of the esodeviations did not have associated vertical strabismus (67.6%, n  =  50). Overall success rate was 48.1% for BMR recessions and 54.5% for 3–4 muscles surgery. Survival analysis revealed the decreasing trends of survival but plateauing of outcomes after 6 months. Conclusion We reported the outcomes for both surgeries. Neither had shown superiority over the other. After a mean follow up of 9.9 months, the overall success was relatively good: 50% were successful, 39.2% overall recurrence and 13.8% overcorrections. Survival plots showed a plateauing of results after 6 months.
Fabrication of cost-effective double layers composite for efficient sound-absorbing based on sustainable and flame-retardant jute fabrics
Authors: El-Basheer Tarek M , El Ebissy Amal A , Attia Nour F 
Published: April 2022

Noise pollution is rapidly increasing, posing a health risk, particularly in the low frequency range. Therefore, the development of cost-effective, environmentally friendly and efficient audible sound absorbing materials is a necessary and crucial process. To this end, smart multilayer sound absorber has been developed based on micro-perforated panels and Jute fabrics as renewable and eco-friendly sound-absorbing material. Different perforation shapes have been fabricated and used for micro-perforated panels and optimized. The sound absorption properties for the new developed sound-absorbing system were evaluated inside a two-microphone impedance tube achieving outstanding results. The developed sound-absorbing system achieved higher sound absorption properties recording more 70% at low frequencies range (<500 Hz), also achieved excellent sound absorption coefficient with broad bandwidth. Furthermore, the flammability properties of the used Jute fabrics were evaluated achieving flame retardancy property of 44 mm/min rate of burning and 20% LOI value. Additionally, the Jute fabrics mechanical and surface morphology properties were investigated. Hence, this study presents a smart, cost-effective, flame retardant and efficient absorption system suitable for noise control for a wide applications range.
Perioperative and long-term complications following therapeutic internal carotid artery occlusion
Authors: Akimoto Taisuke , Ito Yoshiro , Akutagawa Kazuki , Sato Masayuki , Hayakawa Mikito , Marushima Aiki , Takigawa Tomoji , Tsuruta Wataro , Kato Noriyuki , Suzuki Kensuke , Uemura Kazuya , Yamamoto Tetsuya , Matsumaru Yuji 
Published: April 2022

Background Parent artery occlusion (PAO) is an effective treatment for hemorrhagic diseases associated with the internal carotid artery. There are several reports of long-term cerebral infarction or the formation of de novo cerebral aneurysms following PAO. Materials and methods We retrospectively reviewed these complications in 38 patients who underwent PAO for therapeutic treatment. We investigated perioperative cerebral infarctions, long-term cerebral infarctions, and de novo aneurysms. Results The mean age of the patients was 64.0 years, and 25 patients (65.8%) were female. The causative diseases were unruptured (n = 19; 50.0%) and ruptured (n = 8; 21.1%) aneurysms. PAO was performed after ischemic tolerance was assessed with balloon test occlusion (BTO), and BTO was performed in 34 patients, of whom 25 (73.5%) had ischemic tolerance. Twenty-six patients (68.4%) were treated with PAO alone, eight (23.5%) with low-flow bypass, and six (17.6%) with high-flow bypass. Perioperative complications occurred in five patients (13.2%): two of the 26 patients (7.7%) who underwent scheduled treatment and three of the 12 patients (25.0%) who underwent emergency treatment. One patient (2.6%) had long-term de novo aneurysm, and none developed cerebral infarction. Conclusions These results showed that the assessment of ischemic tolerance by performing BTO and appropriate revascularization in scheduled treatments are important to reduce perioperative and long-term cerebral infarctions. PAO must be performed with greater caution in emergency treatment.
Kidney transplantation reduces the risk of chronic limb threatening ischemia and amputation among patients with end-stage renal disease on hemodialysis
Authors: Galarza Tapia Andres , Velescu Alina , Collado Nieto Silvia , Cao Baduell Higinio , Ruiz-Carmona Carlos , Mateos Torres Eduardo , Redondo Pachon Maria Dolores , Clara Velasco Albert 
Published: April 2022

Objective This study aimed to analyze the risk of chronic limb threatening ischemia (CLTI) or amputation among patients with end-stage renal disease (ESRD) entering a hemodialysis (HD) program and to evaluate the protective effect associated with kidney transplantation (KT). Design, Material and Methods Retrospective cohort of all consecutive ESRD patients entering into a HD program at our institution between 2000 and 2010. Collected variables included baseline characteristics (pre-entry in hemodialysis), time on HD program, KT and the composite outcome of chronic limb threatening ischemia or need for any amputation (CLTI/AMP). Patients with previous symptomatic peripheral arterial disease or amputation were excluded. Results The study group included 336 patients (mean age 63 years, 66% male). The mean follow up was 6.7 years with an average time on HD of 4.2 years. Ninety two patients (27.4 %) underwent transplantation. CLTI free survival rates were 90.3 % and 82.6 % at 5 and 10 years, respectively. The episodes of CLT involved 28 revascularization procedures (17 endovascular and 11 open surgeries), 18 minor amputations and 20 major amputations. KT was associated with a protective effect over the development of CLTI (HR: 0.065; CI 95% 0.02–0.21) after adjustment for confounding factors. The long-term survival of non-transplanted patients was 45 % and 15 % at 5 and 10 years, respectively and the long-term survival in transplanted patients was 89% and 80% at 5 and 10 years, respectively; but decreased to 47 % at 1 year and 18.2 % at 5 years once CLTI occurred. Conclusion Patients on HD program show a notorious risk of chronic limb threatening ischemia or amputation over time. Once this complication occurs, patient’s survival is markedly reduced. Transplantation confers an independent protective effect over the development of chronic limb threatening ischemia or amputation.