bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promising New Antimalarial Combination Drugs: Garlic and Arteether in
Pregnant Mice Infected with Plasmodium berghei
Authors: Govindan Vathsala Palakkod , Purushothama Krishna Murthy 
Published: January 2022

Background:
Antimalarial prescription remains a challenge in pregnant women because of
maternal and fetal complications. Recently, garlic and α-β-arteether combination treatment in malariainfected
mice conferred protection. The purpose of this study is to evaluate the efficacy of these drugs
during malaria in pregnancy and its safety measures.

Objective:
The study evaluates the efficacy of arteether and garlic combination drugs in protection
against malaria-infected pregnant mice.

Methods:
Plasmodium berghei-infected pregnant mouse model was used to assess the combination
drug efficacy and the outcome of abnormalities of the disease after drug treatment. After optimizing
the dose and gestation period, maternal protection was confirmed by parasite clearance in smear and
mortality observation. In addition, maternal hematological parameters, different organ histopathology,
and IgG levels were documented along with the fetal and infant outcomes.

Results:
Arteether monotherapy resulted in spontaneous fetal abortion or resorption, while dosage
optimization and garlic combination resulted in pregnancy completion and malaria protection. The
derangements observed in the histoarchitecture of organs and hematological parameters caused by
malaria infection revealed improvement after drug treatment, and the smear observation confirms the
clearance of malaria parasite in the peripheral blood, but IgG level was maintained at the same higher
level as in malaria-infected mice.

Conclusions:
The first report of an arteether and garlic combination demonstrating high efficacy in
protecting against malaria-infected pregnant mice establishes its safety as a viable possible treatment
for pregnancy-associated malaria.
Production of Urea/Acetylated-lignin Sulfonate Matrix as SRFs
and an Investigation on the Effect of Hydrodynamic Conditions on
Release Rate Using the Biot Number
Authors: Moradi Samira , Shayesteh Keivan , Mohammadzadeh Qasem 
Published: January 2022

Background:
This study aimed to investigate the effect of hydrodynamic conditions on
the release rate of urea/acetylated lignin sulfonate (Ac-LS) matrix as slow-release fertilizers
(SRFs). Therefore, two models were developed using the mass transfer balance for the determination
of finite/infinite volume of fluids and solving finite integral transformation/separation of a variable.
The Biot number, validating the hydrodynamic condition, was found in these models.

Methods:
In this study, the urea/Ac-LS matrix fertilizer was prepared. The morphological, thermal,
chemical, and mechanical properties of the LS, Ac-LS, urea, and urea/Ac-LS matrix were analyzed
using Fe-SEM, TGA, XRD, and SANTAM. Finally, the nitrogen release of the matrix fertilizer
was investigated at 25°C for different impeller speeds. The models were also validated using the
experimental data.

Results:
The results showed that the thermal and mechanical resistance of urea/Ac-LS due to
strong interaction increased compared to pure urea or Ac-LS. The results further showed that the
external resistance on the mass transfer decreased as the impeller speed increased, and the nitrogen
release rate increased as the Biot number increased in both the states, i.e., finite and infinite.

Conclusion:
It was also observed that the release rate in the finite environment was less than that
of the infinite one in the given hydrodynamic condition initially; however, the type of environment
did not affect the release rate after a while.
Anatomía radiológica: alternativa en la enseñanza de anatomía. Percepción y desempeño de estudiantes de medicina
Authors: Cheng Chang Chan Ana Yoe , Mejía Bogran Lilliam Liseth , Chavarría Rugama Esaú Manuel , Osmany Sotelo Norvin , Robles Aráuz Diego Manuel 
Published: January 2022

Introducción: En países con escasos recursos, la disección como medio para enseñar anatomía no es factible a menudo, debido a la disponibilidad limitada de cuerpos, alto costo y riesgos de seguridad. En Nicaragua, la anatomía y radiología se estudia de forma independiente.Objetivo: El objetivo del estudio es explorar el impacto (desempeño y percepciones) del uso de imágenes radiológicas en la enseñanza de anatomía en estudiantes de medicina de un país con bajos recursos. Método: Se implementó un curso extraescolar de anatomía radiológica a estudiantes de medicina de tercer (n=87) y sexto (n=67) año. Se aplicó una pre/posprueba y una encuesta posterior al curso. Se calcularon la media, mediana y desviación estándar, con un nivel de intervalo de confianza del 95%.Resultados: Las percepciones de ambos grupos fueron similares. Relacionado a las técnicas radiológicas: TC (82.8% junior y 94% senior) fue la más útil; y la ecografía la menos (49.4% junior y 67.2% senior). Aceptación de recursos didácticos: guía de estudio (73.6% junior y 82.1% senior) y atlas digital interactivo (69% junior y 80.6% senior) obtuvieron la puntuación más alta; mientras que los libros impresos (36.8% junior y 59.7% senior) obtuvieron la puntuación más baja. Los puntajes previos a la prueba fueron similares en ambos grupos (media de respuesta correcta 7.98 junior y 8.22 senior). En la posprueba, la media de aciertos aumentó en ambos grupos: 32.03 para junior y 32.82 para senior (p=0.000).Conclusiones: La integración de la radiología y la anatomía tiene un impacto positivo en los estudiantes de medicina, debe implementarse a través de un enfoque de aprendizaje autodirigido, y considerarse complementaria en el plan de estudios médico como una buena alternativa para enseñar anatomía en países donde la disección no es factible.
Complejación de metales por sustancias húmicas acuáticas como proceso natural, tomando como caso de estudio el Lago de Xochimilco
Authors: González-Guadarrama María de Jesús , Castillo-Blum Silvia Elena , Armienta María Aurora 
Published: January 2022

Abstract 22
This work discusses the importance of organic matter, specifically Aquatic Humic Substances (SHA) 23 within the speciation and distribution of metals within an aquatic system, in this case Xochimilco 24 Lake, a site with great ecological importance. This lake is the natural habitat of the endemic species 25 “axolotl” (ajolote). In this research, complexation reactions between SHA and metals (Cu, Mn, Pb 26 and Zn) were carried out under different reaction conditions, the source of AHS was water samples 27 taken in Xochimilco Lake in presence and absence of pH buffer dissolution and varying the 28 concentration of metals. The results show that there is a direct competition between the major 29 elements and trace elements to react with the AHS. Under the pH conditions of Xochimilco Lake 30 complexes formation is possible. 31
PENGARUH KOMUNIKASI PEMASARAN YANG DILAKUKAN OLEH DOSEN TERHADAP MINAT BACA MAHASISWA PADA PERPUSTAKAAN PERGURUAN TINGGI NEGERI DI JAKARTA SELATAN
Authors: Sasmita Surya Adi 
Published: January 2022

The College Library was established to support academic needs both for the internal public and the external public of the college itself. However, the development of communication technology has made the interest in reading students in college libraries decrease. Therefore college libraries must implement the right strategies to increase students' reading interest in the library. Through this study, researchers found the influence of marketing communication strategies carried out by lecturers (variable x) on students' reading interest (variable y) by 72%. This shows that lecturers should also provide socialization and direction to students related to the importance of reading reference sources from campus libraries by telling interesting things so that students' reading interest in college libraries increases librarians in college libraries can make lecturers as co-workers in carrying out lecturer marketing communication strategies considering are individuals whose daily life is more interact with students so that lecturers have an important role in carrying out library marketing communication to students.
Genetic Risk Score Enhances Coronary Artery Disease Risk Prediction in Individuals With Type 1 Diabetes
Authors: Lithovius Raija , Antikainen Anni A. , Mutter Stefan , Valo Erkka , Forsblom Carol , Harjutsalo Valma , Sandholm Niina , Groop Per-Henrik 
Published: January 2022

OBJECTIVE
Individuals with type 1 diabetes are at a high lifetime risk of coronary artery disease (CAD), calling for early interventions. This study explores the use of a genetic risk score (GRS) for CAD risk prediction, compares it to established clinical markers, and investigates its performance according to the age and pharmacological treatment.

RESEARCH DESIGN AND METHODS
This study in 3,295 individuals with type 1 diabetes from the Finnish Diabetic Nephropathy Study (467 incident CAD, 14.8 years follow-up) used three risk scores: a GRS, a validated clinical score, and their combined score. Hazard ratios (HR) were calculated with Cox regression, and model performances were compared with the Harrell C-index (C-index).

RESULTS
A HR of 6.7 for CAD was observed between the highest and the lowest 5th percentile of the GRS (P = 1.8 × 10−6). The performance of GRS (C-index = 0.562) was similar to HbA1c (C-index = 0.563, P = 0.96 for difference), HDL (C-index = 0.571, P = 0.6), and total cholesterol (C-index = 0.594, P = 0.1). The GRS was not correlated with the clinical score (r = −0.013, P = 0.5). The combined score outperformed the clinical score (C-index = 0.813 vs. C-index = 0.820, P = 0.003). The GRS performed better in individuals below the median age (38.6 years) compared with those above (C-index = 0.637 vs. C-index = 0.546).

CONCLUSIONS
A GRS identified individuals at high risk of CAD and worked better in younger individuals. GRS was also an independent risk factor for CAD, with a predictive power comparable to that of HbA1c and HDL and total cholesterol, and when incorporated into a clinical model, modestly improved the predictions. The GRS promises early risk stratification in clinical practice by enhancing the prediction of CAD.
Association Between Change in Accelerometer-Measured and Self-Reported Physical Activity and Cardiovascular Disease in the Look AHEAD Trial
Authors:   Look AHEAD Study Group
Published: January 2022

OBJECTIVETo conduct post hoc secondary analysis examining the association between change in physical activity. Measured with self-report and accelerometry, from baseline to 1 and 4 years and cardiovascular disease (CVD) outcomes in the Look AHEAD Trial.RESEARCH DESIGN AND METHODSParticipants were adults with overweight/obesity and type 2 diabetes with physical activity. Data at baseline and year 1 or 4 (n = 1,978). Participants were randomized to diabetes support and education or intensive lifestyle intervention. Measures included accelerometry-measured moderate-to-vigorous physical activity (MVPA), self-reported physical activity, and composite (morbidity and mortality) CVD outcomes.RESULTSIn pooled analyses of all participants, using Cox proportional hazards models, each 100 MET-min/week increase in accelerometry-measured MVPA from baseline to 4 years was associated with decreased risk of the subsequent primary composite outcome of CVD. Results were consistent for changes in total MVPA (hazard ratio 0.97 [95% CI 0.95, 0.99]) and MVPA accumulated in ≥10-min bouts (hazard ratio 0.95 [95% CI 0.91, 0.98]), with a similar pattern for secondary CVD outcomes. Change in accelerometry-measured MVPA at 1 year and self-reported change in physical activity at 1 and 4 years were not associated with CVD outcomes.CONCLUSIONSIncreased accelerometry-measured MVPA from baseline to year 4 is associated with decreased risk of CVD outcomes. This suggests the need for long-term engagement in MVPA to reduce the risk of CVD in adults with overweight/obesity and type 2 diabetes.
PENGARUH PENERAPAN MODEL PEMBELAJARAN PROBLEM SOLVING TERHADAP HASIL BELAJAR SISWA DI SMK NEGERI 1 PADANG
Authors: Anuari Ridwannur , Zola Prima 
Published: January 2022

Penelitian ini dilatar belakangi oleh model pembelajaran yang digunakan oleh guru di SMK N 1 Padang belum sesuai dengan karakteristik mata pelajaran. Hal ini dapat dilihat dari hasil belajar siswa pada mata pelajaran Dasar-dasar Konstruksi Bangunan dan Teknik Pengukuran Tanah masih banyak yang belum memenuhi KKM. Untuk itu dalam mengatasi permasalahan tersebut maka perlu diterapkan model pembelajaran yang memberikan perluasan kreativitas dan berfikir kritis kepada siswa. Tujuan penelitian ini adalah untuk mengungkapkan pengaruh model pembelajaran Problem solving terhadap hasil belajar siswa pada mata pelajaran Dasar-dasar Konstruksi Bangunan dan Teknik Pengukuran Tanah Kelas X Bisnis Konstruksi dan Properti SMK Negeri 1 Padang. Jenis penelitian ini adalah Quasi Experiment (Eksperimen Semu) dengan design Pretest-Posttest Control Group Design. Populasi penelitian ini adalah siswa kelas X SMKN 1 Padang yang terdaftar pada tahun ajaran 2019/2020 yang terdiri dari kelas X BKP A dan X BKP B. Dari kedua kelas ini dipilih salah satu sebagai kelas eksperimen, dan kelas kontrol. Pengujian instrumen dilakukan di sekolah yang sama menggunakan validasi ahli dengan cara mmengkonsultasikan dengan guru mata pelajaran. Pengumpulan data dalam penelitian ini menggunakan tes hasil belajar (pretest dan posttest) berupa soal objektif sebanyak 25 soal. Data yang dianalisis menggunakan uji perbedaan dua rata-rata (t-test). Berdasarkan hasil penelitian ditemukan bahwa kelas eksperimen yang menggunakan model pembelajaran Problem Solving memiliki nilai rata-rata (81,6774) yang lebih tinggi dibandingkan kelas kontrol dengan menggunakan model pembelajaran konvensional dengan nilai rata-rata (68,5161). Sedangkan dari perhitungan t-test diperoleh thitung besar dari ttabel. Dengan demikian hipotesis yang dikemukakan dapat diterima pada taraf kepercayaan 95 %. Sehingga hasil dari penelitian ini menunjukkan bahwa terdapat pengaruh model pembelajaran Problem Solving terhadap hasil belajar siswa pada mata pelajaran Dasar-dasar Konstruksi Bangunan dan Teknik Pengukuran Tanah kelas X BKP SMK Negeri 1 Padang.
Pembuatan Media Pembelajaran Interaktif Berbasis Android pada Mata Kuliah Struktur Beton
Authors: Ulfiah Tiara Afrilliana , Zola Prima 
Published: January 2022

Umat manusia sedang dilanda musibah pandemi Covid-19 yang menyebabkan tantangan bagi pendidikan. Proses pembelajaran dilakukan secara daring sehingga membutuhkan media pembelajaran interaktif untuk menunjang pembelajaran. Media pembelajaran yang digunakan pada pada mata kuliah Struktur Beton belum memadai. Penelitian ini bertujuan untuk menghasilkan media pembelajaran interaktif berbasis Android. Penelitian ini menggunakan tahapan Research and Development yang mengadaptasi model 4D. Instrumen yang digunakan berupa angket penilaian media pembelajaran untuk ahli media, ahli materi dan mahasiswa. Berdasarkan penilaian produk terhadap media pembelajaran interaktif berbasis Android pada mata kuliah Struktur Beton oleh ahli media memperoleh skor 4,3 pada aspek kemudahan, audio, kemudahan penggunaan dan navigasi serta interaktivitas masuk kategori sangat baik. Penilaian oleh ahli materi 1 diperoleh skor 4 masuk dalam kategori baik, sedangkan penilaian oleh ahli materi 2 diperoleh skor 4,5 masuk dalam kategori sangat baik pada aspek kemudahan, kesesuaian, kualitas isi dan tujuan serta kualitas instruksional. Penilaian dari 20 mahasiswa memperoleh persentase 82,95% masuk dalam kategori sangat praktis. Berdasarkan hasil penelitian, maka media yang dihasilkan dinyatakan sangat baik.
Studi Eksperimental Kapasitas Geser Dinding Bata dengan Penambahan Jaring Kawat
Authors: Nofriadi Nofriadi , Dary Rhini Wulan , Sitompul Mizanuddin , Melinda Annisa Prita 
Published: January 2022

Kerusakan yang sering terjadi pada dinding bata adalah kerusakan geser yang dicirikan dengan adanya retak atau patahan searah diagonal bidang dinding bata. Kerusakan geser pada suatu bangunan harus sangat dihindari, hal ini disebabkan sifat dari keruntuhan geser yang tiba-tiba dan getas. Apabila suatu bangunan mengalami keruntuhan geser maka bangunan tersebut dapat secara tiba-tiba runtuh dan akibatnya penghuni tidak sempat untuk menyelamatkan diri. Untuk mengatasi keruntuhan geser yang teradi pada dinding bata perlu diberikan perkuatan. Pada penilitian ini akan dilakukan pengujian terhadap dinding bata yang diberikan variasi penambahan jaring kawat. Terdapat sembilan buah sampel dengan ukuran 35 cm x 35 cm yang akan dilakukan pengujian geser diagonal dinding bata, sampel tersebut 3 buah sampel dinding bata tanpa penambahan jaring kawat (DBK), 3 buah sampel dinding bata dengan penambahan jaring kawat 0,5” x 0,5 “(DBJK A), dan buah sampel dinding bata dengan penambahan jaring kawat 1”x1”(DBJK B). Pengujian geser diagonal dinding bata merah menggunakan alat UTM dilaboratorium. Dari hasil pengujian dapat dilihat bahwa penambahan jaring kawat memberikan kontribusi peningkatan kemampuan dinding bata untuk menahan beban . terjadi peningkatan kekuatan sebesar 68,66 % dan 29,55 % antara dinding bata tanpa jaring kawat dan dinding bata dengan penambahan jaring kawat. Selanjutnya dilakukan pengolahan data untuk mendapatkan nilai kapasitas geser dinding bata. Terjadi peningkatan kapasitas geser dinding bata sebesar 68,42 % dan 29, 47 % dari dinding bata tanpa penambahan jaring kawat.
Analisis Kualitas Udara Karbonmonoksida (Co) di Kota Padang Akibat Kebijakan Pembatasan Sosial Berskala Besar (PSBB) dengan Metode AQMS
Authors: Irawan Andi , Riyandini Vina Lestari , Widyastuti Nini 
Published: January 2022

Pada akhir 2019 penyebaran Corona Virus Disease 19 atau lebih dikenal dengan virus corona menular ke manusia dengan sangat cepat dan telah menyebar ke hampir semua negara termasuk Indonesia hanya dalam waktu beberapa bulan. menyebabkan negara-negara didunia melakukan kebijakan lockdown dengan pengisolasian suatu kawasan untuk mencegah penularan virus yang menyebabkan berkurangnya aktivitas luar ruangan sehingga mempengaruhi konsentrasi kadar karbonmonoksida (CO) diudara. Dari hasil penelitian didapatkan selama PSBB tanggal 22 April s/d 05 Mei 2020 didapatkan rata-rata nilai CO tertinggi pada tanggal 22 April 2020 sebesar 292.33 µg/m. Sedangkan pada kondisi pada 22 April s/d 05 Maret 2019 didapatkan nilai tertinggi pada 01 Mei 2019 sebesar 305.46 µg/m³. Dan dari hasil uji stratistik perbedaan konsentrasi dari kedua kondisi tersebut didapatkan nilai regresi sebesar 0,228 sehingga hal ini menunjukkan tidak ada perbedaan secara signifikan terhadap penurunan karbonmonoksida sebelum dan setelah psbb. Penerapan PSBB secara garis besar tidak berpengaruh terhadap kualitas udara.
Pelatihan Aplikasi Autodesk Civil 3D Pada Mata Diklat Konstruksi Jalan dan Jembatan Bagi Para Guru Jurusan Bangunan di Kabupaten 50 Kota
Authors: Oktaviani Oktaviani , Andreas Laras Oktavia , Ashar Faisal 
Published: January 2022

Revisi kurikulum pendidikan di Indonesia terjadi pada kurikulum Sekolah Menengah Kejuruan (SMK) yaitu kurikulum 2013 yang dikeluarkan oleh Direktur Jendral Pendidikan Dasar dan Menengah No. 130/D / KEP/ KR/ 210 Tanggal 10 Februari 2017. Perubahan tersebut, berpengaruh kepada bidang studi, keahlian, mata pelajaran, dan materi ajar. Hal ini membutuhkan persiapan guru dalam menerapkan kurikulum tersebut. Guru perlu menyesuaikan kemampuan dan keahlian dengan materi dalam revisi kurikulum. Salah satu kompetensi keahlian di SMK, khususnya Jurusan Bangunan yang mengalami perubahan pada Kurikulum 2013 adalah kompetensi Keahlian Desain Permodelan dan Informasi Bangunan yang dahulunya disebut dengan Kompetensi Keahlian Gambar Bangunan pada mata pelajaran produktif yaitu penambahan mata pelajaran Konstruksi Jalan dan Jembatan. Jurusan Bangunan di SMK Negeri Kabupaten 50 Kota diberi nama Jurusan Teknik Konstruksi dan Properti. Penambahan ini membutuhkan guru yang menguasai keahlian tersebut, namun guru yang ada kurang menguasai karena materi tergolong materi baru dan perlu tingkat pemahaman tinggi. Oleh karena itu, dilakukan kegiatan Program Kemitraan Masyarakat (PKM) untuk guru Jurusan Bangunan (Teknik Konstruksi dan Properti), dengan materi penerapan Perencanaan Gambar Jalan dan Jembatan menggunakan Aplikasi Autodesk Civil 3D. Tujuan dari pelaksanaan pengabdian ini adalah ikut serta dalam penerapan Kurikulum 2013. Kegiatan PKM tersebut, peserta mendapatkan pengetahuan dan pelatihan/praktek langsung dalam aplikasi perencanaan jalan dan jembatan serta setelah pelatihan dapat diterapkan pada siswa sehingga tercapai tujuan pembelajaran dari mata diklat Konstruksi Jalan dan Jembatan
Teaching English by using E-learning during COVID-19 Pandemic Time
Authors: Rizqy Az Fathur 
Published: January 2022

COVID-19 a public health crisis of worldwide importance was announced by the World Health Organization (WHO) in January 2020 as a new corona virus disease outbreak and was reported as a pandemic in March 2020. Mr. Joko Widodo, the President of Republic of Indonesia, has instructed all Indonesian citizens to practice social and physical distance. To reduce the spread of COVID-19, the Indonesian government implemented certain preventive measures. Mr. Nadiem Anwar Makarim, Indonesia’s Minister of Education and Culture, has instructed all students, including University students to study from home. A descriptive qualitative research was used to conduct this study. The study’s findings show that in the event in the event of a pandemic, the E-learning system is the only possible teaching learning approach. Teachers and students simply connected to the internet from their homes and were connected to an approved E-learning program by the institutions or lecturers. However, there were undeniable challenges in implementing E-learning, such as a lack of internet access or WIFI, learners getting unmotivated and insufficient levels of student engagement. Affective domains appeared to be minimized in E-learning systems due to a lack of actual social and psychological interactions between teacher and students. The interactive teacher-student discussion is not as productive as it would be in a conventional teaching.
Blended Learning in Package C Equality Programs in Facing New Normal Education
Authors: Rita Yeni , Safitri Nadia 
Published: January 2022

The background of this research is the occurrence a big disaster in this era that hit all of the worlds and makes an impact in various shock and various sector, including the education sectors. The package C program also experienced the impact of this pandemic by not allowing face to face and closely, so the citizens learn difficulties in learning. The purpose of this research is to offer an option in the form of a learning model for Package C learning citizens, namely blended learning. On the other hand, the purpose of this research also to show the benefits of blended learning to package C program to faced new normal education. The result of this research is showing to effectively blended learning applied to the package C program, especially during this pandemic. The benefits obtained by the citizens of learning in blended learning are: (1) citizens learn are more used to technology in learning; (2) to reduce the dependence on the presence of tutor in learning face to face learning; and (3) allow them the opportunity to go into online business. The researcher hoped that blended learning will be further encouraged till citizens learn to be more independent in learning and tutors or are expected to be able to adjust to the new normal education. Keywords: blended learning, package C, New normal education.