bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bourneville-Pringle disease (Tuberous Sclerosis Complex - TSC) with bilateral renal angiomyolipoma and an epitheloid monomorf angiomyolipoma (EM-AML) in a 43-year- old female, a case report
Authors: Mate Kinga , Márványkövi Fanni , Vrecenár László , Zóber Tamás , Buzogány István , Beöthe Tamás 
Published: February 2022

Abstract
Background: The Bourneville Pringle disease, also called tuberous sclerosis complex (TSC) is a rare genetic disorder with dominant autosomal inheritance. It is a rare neurocutaneous disorder, which can affect numerous internal organs, for example the kidney(s), the heart, and the lungs. The formation of multiple hamartomas is causing the multiorgan systemic involvement. Case presentation: A 43-year-old patient presents with tuberous sclerosis, an autosomal dominant inherited neurocutaneous disorder which variably affects different organs, among them the kidneys. During follow-up the abdominal computer tomography (CT) showed bilateral angiolipomatosis (AML) and a fat-poor mass with a different solid aspect on the left side. A fat-poor AML can be a challenge to diagnose. It is vital to exclude malignancy to decide on further management. A CT guided biopsy was performed. The results showed an atypical renal angiomyolipoma, a rare monomorph, epitheloid type. A genetic examination was performed, which showed a mutation of the TSC2 genes. Conclusions: The Bourneville Pringle disease is a rare genetic, neurocutaneous disease, which can affect multiple organs by the formation of hamartomas, including renal manifestation as AML. In case of radiological findings of a fat poor CT component AML it is essential to keep in mind the possibility of a rare monomorph epitheloid AML and if there is any doubt, it is crucial to exclude malignancy by using biopsy. A fat-poor AML can be a challenge to diagnose. It is vital to exclude malignancy, to take the size of the kidney AML in consideration, the high risk of potentially massive hemorrhage to decide on further management.
Low-Value Recyclable Waste Regeneration in China: High-Efficiency Automatic Sorting Method and Experimental Research
Authors: Ji Tianchen , Fang Huaiying , Zhang Rencheng , Yang Jianhong , Fan Lulu , Li Jiantao 
Published: February 2022

Abstract
The municipal domestic waste (MDW) generated in China is increasing year by year, but the waste that has been regenerated is very little. In order to efficiently sort low-value recyclable waste (LVRW), which is the largest recyclable part of MDW, we designed and manufactured a machine vision pneumatic sorting equipment with waste recognition accuracy higher than 92%. Furthermore, an automated sorting method combining Mechanical sorting, near-infrared (NIR) sorting and machine vision sorting was developed specifically for MDW sorting. In field applications, the entire automated production line we built divides MDW (100%) into six types (37.7%) of single material waste and three types (33%) of composite waste, which is very beneficial to the recycling of resources in the future.
Dynamics of SAR-CoV2 Viral Load Decline and Antibody Responses in COVID-19 Patients
Authors: Auewarakul Prasert , Sirihongthong Thanyaporn , Boonarkart Chompunuch , Jitobaom Kunlakanya , Phakaratsukul Supinya , Wongsawat Ekkarat , Nimitvilai Sireethorn , Suputtamongkol Yupin 
Published: February 2022

Abstract
This study describes changes in the viral RNA, viable virus shedding and host immune response in COVID-19 patients. Samples showed a large variation of viral load which declined rapidly in the first week and gradually afterward. Most cases with persistent positive of viral RNA (approximate 80%) did not indicate shedding of viable virus. Some cases with undetectable specific antibody (9 from 26 cases) were viral culture positive. These indicate that delaying of immune response may result in persistent shedding of viable virus. High viral load and negative neutralizing antibody may be used as markers to identify such individuals.
Is there a causal relationship between the consequences of preoperative weight control using orlistat-based intervention and the result after one-anastomosis gastric bypass? A retrospective study
Authors: Lo Hung Chieh , Hsu Shih-Chang 
Published: February 2022

Abstract
BackgroundControversies remain regarding the position of preoperative weight control. Orlistat, which shares a mechanism of restricting dietary fat absorption with gastrointestinal bypass procedures, has long been widely used for weight management. The aim was to assess the mutual relationship between the results of preoperative weight control with orlistat and surgical outcomes after one-anastomosis gastric bypass (OAGB).MethodsThe medical records of all consecutive patients with body mass index (BMI) ≥ 42.5 kg/m2 who underwent primary OAGB from 2014 to 2020 were retrospectively reviewed. Orlistat was routinely suggested for this subgroup and prescribed 10-14 days preceding surgery. Patients were stratified into weight reduction (Group 1) and weight gain (Group 2) groups. The variables assessed included the correlation of pre- and postoperative weight change up to 3 years postoperatively and 30-day surgical outcomes.ResultsAmong 55 patients who fulfilled the inclusion criteria and were compliant with treatment, 35 (64%) patients lost a median of 2.0 kg, in contrast to a median weight gain of 2.9 kg in Group 2. Group 1 had a significantly higher BMI (48.9 kg/m2 vs. 44.6 kg/m2; p= 0.003) at the last clinic visit and included more females (54% vs. 25%) than Group 2. There was a trend of reduced surgical duration (107 min vs. 140 min; p= 0.109), with no difference in 30-day complications. Weight loss percentages between groups were not different at 24 months.ConclusionPreoperative weight loss with orlistat reduced the operation time but did not affect weight loss at 2 years.
Impaired expression of BCAT1 relates to muscle atrophy of mouse model of sarcopenia
Authors: Ouyang Hui , Gao Xuguang , Zhang Jun 
Published: February 2022

Abstract
Background The underlying mechanism of muscle atrophy in sarcopenia is still not fully understood; BCAT1 isocitrate dehydrogenase-1 encodes an evolutionarily conserved cytoplasmic aminotransferase for glutamate and branched-chain amino acids (BCAAs), thus constituting a regulatory component of cytoplasmic amino and keto acid metabolism. In human gliomas carrying wild-type isocitrate dehydrogenase-1, BCAT1 promotes cell proliferation through amino acid catabolism. Hence, the goals of this study were to unravel the potential role of BCAT1 expression in muscle atrophy and to explore the mechanisms underlying this process.MethodsWe first measured BCAT1 expression by RT-qPCR and western blotting in murine and cellular models of muscle atrophy. To understand how the BCAT1-driven changes sustained muscle cell growth, we analyzed ROS levels and activation of the mTORC1/S6K1 pathway in muscle cells. Furthermore, we performed CCK8 assays and fluorescence staining to evaluate growth rate of cells and ROS levels. Finally, we verified that depletion of BCAT1 impairs the growth rate of muscle cells and increases ROS levels, indicating that muscle atrophy resulted from the downregulation of the mTORC1/S6K1 pathway. Data were analyzed by two-tailed unpaired Student’s t-test or Mann-Whitney U test for two groups to determine statistical significance. Statistical analyses were performed using GraphPad Prism version 6.0 and SPSS 16.0 software.ResultsBCAT1 expression level in skeletal muscles was lower in murine and cellular models of sarcopenia than in the control groups. BCAT1 knockdown not only suppressed the growth of muscle cells but also increased the production of ROS. Impaired cell growth and increased ROS production was rescued by co-introduction of an shRNA-resistant BCAT1 cDNA or addition of the mTORC1 stimulator MYH1485. Muscle cells with BCAT1 knockdown featured lower mTORC1 and S6K1 phosphorylation (pS6K1) than NT muscle cells. Addition of either shRNA-resistant BCAT1 cDNA or MYH1485 rescued the suppression of cell growth, increase in ROS production, and decrease in pS6K1. ConclusionsThe BCAA catabolic enzyme BCAT1 is essential for the growth of muscle cells. BCAT1 expression contributes to sustained growth of muscle cells by activating mTOR signaling and reducing ROS production.
Replacement of sodium silicate-based alkali activator by rice husk ash in geopolymer production
Authors: Chokkha Siriwan , Ayawanna Jiratchaya , Poowancum Anurat 
Published: February 2022

Abstract
Rice husk ash was used as an active-SiO2 source for the production of low-cost metakaolin based geopolymer. For cost reduction, active-SiO2 from husk ash was used as an alternative Na2SiO3 activator replacement. The starting materials such as metakaolin, husk ash and NaOH with SiO2/Al2O3 ratios of 1.58 - 1.95 were studied and calculated by XRF results. The fast hardening of geopolymer from husk ash occurred after curing at room temperature for 24 hrs. The strength of all samples was enhanced by increasing the amount of active-SiO2 from husk ash. The geopolymer from husk ash with SiO2/Al2O3 ratio of 1.95 showed high compressive strength with a value of 25 MPa. The production cost of geopolymer from husk ash was decreased with the value of 84.78%. Husk ash is an alternative natural active-SiO2 for replacing Na2SiO3 activator in the geopolymer manufacturing process, indicating a decrease in the cost of the process.
Interaction between 694nm red (ruby) laser photons and a static magnetic field – evidence for charge and mass of the photon
Authors: Haywood Rachel 
Published: February 2022

Abstract
Photons are described by particle and wave theories. It is accepted photons do not possess mass, charge nor are deflected by a magnetic field. A 2005 review concluded photon mass was mathematically feasible, but lacked experimental evidence [1]. During electron-spin-resonance experiments, hair containing melanin was 694 nm laser-irradiated. An ‘off-resonance’ at laser-firing was observed in a time-scan at constant magnetic field, whilst monitoring laser-induced radical formation [2]. It was hypothesised coherent photons interacted with the field, suggesting charge, magnetism and mass. The radical g-value was invariant in successive field-scans, although the hair melted. Melanin in the solid state in hair, does not exhibit temperature-dependent paramagnetism [3]. 2.2 – 3.6 x 1019 photons in 6 – 10 J were calculated to be absorbed, and a mean 72% ‘off resonance’ signal-drop determined from the time-scan, translates to a field-shift of 4 G or 4 x 10-4 T. If the pulse is a point charge (Nphoton .qphoton) with Nphoton the photon number and qphoton the charge per photon, then from the Biot-Savart equation qphoton can be calculated from 0.0004.(Nphoton x 29.98/r2)-1, where r is 1 m, and is 3.6 – 6.1 x 10-25 coulombs. The calculated collision photon : electron charge (q/e) approaches 3 x 10-6. If qphoton is extrapolated for photons moving in air/space by a ‘dilution factor’ of 106 then q/e would be 10-13 and comparable to laboratory-based measurements of 10-14-10-17. The observation and calculations suggest photons are charged; discrepancies in the measured values reflect differences in photon speed at the point of measurement.[1] Liang-Cheng Tu, Jun Luo and George T Gillies. The Mass of the Photon. Rep. Prog Phys 2005: 68; 77-130.[2] Rachel M. Haywood and Claire Linge. Differences in Production of Melanin Radicals by 694 nm Ruby Laser and UVA Radiation. Lasers Surg Medicine 2004: 35; 77-83.[3] Shiu-Shin Chio, James S. Hyde and Roger C. Sealy. Temperature-Dependent Paramagnetism in Melanin Polymers. Arch Biochem Biophys 1980: 199; 133-139.
Changes of cardiac magnetic resonance T1 and ECV values in healthy adults of different sex and age
Authors: Huang Shumei , Zhang Meng , Yu Kanghui , Li Chunlong , Lan Zhihong , Feng Ying , Lin Shiqi , Ma Xiaofen , Wu Yunfan , Jiang Guihua 
Published: February 2022

Abstract
[Background] The correlation between T1 and ECV value and myocardial fibrosis has been confirmed, and many disease may change T1 and ECV value. The purpose of this reseach is to clarify the T1 mapping and extracellular volume (ECV) value of healthy adults in 3 Tesla (T) magnetic resonance imaging (MRI), and to study the relationship between the values with age and sex.[Methods] We recruited 87 healthy adult subjects (mean age 38 ± 11 years; 61% were females) for cardiac magnetic resonance examination at 3T MRI. The left ventricular function parameters were obtained from functional imaging. T1 mapping was performed using an improved Look-Locker reversal recovery sequence after motion correction. [Results] Under 3T field strength, T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 value and ECV values of female myocardium were higher than those of males (1,274 ± 56 vs. 1,241 ± 40, P = 0.003; 29.6% ± 2.6% vs. 26.2% ± 2.1%, P < 0.001). Only sex (Beta = 0.311, P = 0.003) was independently related to the native T1 mapping of left ventricular myocardium, while sex (Beta = 0.572, P < 0.001) and age (Beta = 0.501, P = 0.003) were related to the ECV value of left ventricular myocardium. T1 value (P = 0.002) and ECV value (P = 0.013) increased significantly from the base to the apex. There were significant differences in the T1 and ECV value between each segment (P < 0.001) in the base of the left ventricle. [Conclusions] T1 and ECV values of females were significantly higher than those of males. The ECV values of males increased with age, while T1 value in males and T1 and ECV values in females had no significant relationship with age.
Standardized Reporting and Quantification of Whole-Body MRI findings in Children with Chronic Non-Bacterial Osteomyelitis Treated with Pamidronate
Authors: Andreasen Caroline Marie , Klicman Rikke Fuglsang , Herlin Troels , Hauge Ellen Margrethe , Jurik Anne Grethe 
Published: February 2022

Abstract
ObjectivesTo test a modified radiological index for non-bacterial osteitis (mRINBO) used for standardized reporting and quantification of whole-body MRI (WBMRI) findings in children with chronic non-bacterial osteomyelitis (CNO) receiving pamidronate therapy.MethodsWBMRI was assessed in 18 children with CNO at baseline and after receiving pamidronate therapy for one year. Parameters of interest were: number and anatomic site of radiologically active bone lesions (RAL), size of RAL, extramedullary affection, spinal involvement and changes in mRINBO, which includes both the number and maximal size of RAL (RALmax) in addition to extramedullary and chronic changes. ResultsAt the time of diagnosis, the mean age of the children was 9.8 (sd, 8.7-10.9) years and 11/18 were females. The number of RALs per patient decreased from median [interquartile range] 4.5 [3-8] to 3 [2-5] RALs per patient (p=0.02) and extramedullary inflammatory changes regressed. Sixty-one percent of all RALs occurring at baseline resolved and three children became without active inflammatory lesions by WBMRI. However, the median size of RALs did not change when taking new lesions occurring in 7/18 children into account, but RALmax decreased significantly from 39 [29-45] mm at baseline to 28 [20-40] mm (p<0.01) at year-one with a concomitant decrease of mRINBO from a median of 5 [4-7] to 4 [3-5] (p=0.05).ConclusionsmRINBO decreased during pamidronate therapy and mRINBO may be a potential scoring method to quantify changes in radiological disease activity in children with CNO. Further studies are needed to test feasibility and validity of mRINBO.
Promoting health and social equity through family navigation to prevention and early intervention services: a proof of concept study
Authors: Waid Jeffrey , Tomfohrde Olivia , Kutzler Courtney 
Published: February 2022

Abstract
Background. Health and social inequality are associated with multiple adverse childhood experiences including poverty, mental illness, substance abuse, and child maltreatment. While effective interventions currently exist for many health and social problems, large segments of the population experience barriers accessing needed services. In alignment with broader public health efforts to reduce health and social inequality in one state in the U.S.A., the current study describes the development and formative evaluation of a brief, low cost, portable model of prevention-oriented family service navigation called Navigate Your Way. Methods. Caregivers of children experiencing significant unmet health or social service needs were recruited to the study. Participants completed an initial and closing telephone interview which included measures of past and current family health and social service utilization, service barriers, parenting stress, and child internalizing/externalizing behaviors. Between interviews participants created a family service plan and received 10 weeks of telephone and web-mediated family navigation, at which time process and fidelity of implementation data were collected. Frequency and descriptive statistics are provided for participant demographic characteristics, service barriers, intervention engagement, and primary and secondary study outcomes. Paired samples t-tests examined changes in study outcomes between initial and closing telephone interviews. Results. Thirty two caregivers enrolled, twenty-nine completed the study. The age range was 20-59 (M=39.5, SD=10.0). The majority identified as female (96.9%, n=31), racial/ethnic minority (56.2%, n=18), and reported an average 10 barriers to care (M=10.4, SD=4.1). The most frequently reported service needs were mental health care (n=26), housing (n=11), food security (n=8), and health insurance (n=8). The mean duration of intervention delivery was 83 days (M=82.7, SD=9.0, range=74-105). Most participants (82.8%, n=24) were connected to one or more health or social services. Caregivers reported significant improvements to youth internalizing behaviors (M=-1.0, SD=2.5, t(26)=2.1, d=2.5, p=.05) and high levels of overall satisfaction with the navigation approach. Conclusion. Telephone and web-mediated service navigation is a feasible and practical approach to supporting families in rapidly connecting to health and social care. Future research investigating the efficacy and implementation of Navigate Your Way in routine settings is indicated.
The Effect of Crystalloid Co-Loading on Circulatory Stability During General Anaesthesia Induction in ASA II/III Patients for Major Abdominal Surgery: A Randomized Controlled Trial
Authors: Kos Darjan , Kamenik Mirt , Dinevski Dejan 
Published: February 2022

Abstract
BackgroundWe studied the effect of crystalloid co-loading with simultaneous infusion of vasopressor phenylephrine on circulatory stability during general anaesthesia induction with propofol in ASA II/III patients. We analysed the postinduction phase because circulatory instability is most prevalent in this period and more prominent in multimorbid patients. Prevention rather than treatment might be a better strategy to avoid complications associated with even short periods of instability.Methods46 ASA II/III patients were randomly assigned to two treatment groups. During the induction, the control group received an infusion of phenylephrine only and the test group received the same phenylephrine regimen and also a crystalloid co-load. Cardiac index (CI), mean arterial pressure (MAP), stroke volume index (SVI), systemic vascular resistance index (SVRI), stroke volume variation (SVV) and heart rate (HR) were recorded for 18 minutes and the dynamics of change between groups analysed.ResultsCI decreased in both groups after the induction but less in the test group, almost reaching statistical significance (p=0,052). MAP also decreased more in the control group; however, not reaching statistical significance. HR decreased in both groups, significantly more in the test group (p=0,041). SVRI almost identically increased in both groups. SVI decreased in the control group, whereas it significantly increased after initial decrease in the test group (p=0,006). SVV slowly decreased under 10% in the test group and increased over 10% in the control group.ConclusionsOur results show that phenylephrine combined with crystalloid co-loading enables better circulatory stability than phenylephrine alone.Trial registrationThe study was registered on 15th of March 2017 at ISRCTN registry: http://www.isrctn.com/ISRCTN46293288 and was retrospectively registered.Clinical trial number is ISRCTN46293288.
Clinical features and immunophenotypes of double-hit diffuse large B-cell lymphoma
Authors: Wu Cheng-Han , Gau Jyh-Pyng , Teng Chieh-Lin Jerry , Shih Yu-Hsuan , Su Yu-Chen , Wang Ren-Ching , Chen Tsung-Chih 
Published: February 2022

Abstract

Double-hit (DH) genetics induces a reduction in the complete remission (CR) and, consequently, in poor overall survival (OS) in diffuse large B-cell lymphoma (DLBCL) patients. Unfortunately, DH identification is time-consuming. Here, we retrospectively reviewed 92 newly diagnosed DLBCL patients and stratified them into the DH (n = 14) and non-DH groups (n = 78). The clinical features and treatment outcomes were compared between the two groups, and clinical parameters were employed to predict DH genetics. The results revealed that the DH group had a higher percentage of bulky disease than the non-DH group (64.3% vs. 28.2%; p = 0.013). More patients in the DH group tested positive for double expresser (DE) (50.0% vs. 21.8%; p = 0.044). Conversely, the CR rates in these groups were not significantly different (50.0% vs. 60.3%; p = 0.672). The three-year OS rates of patients with and without DH were 28.6% and 49.7%, respectively (p = 0.008). Importantly, DH genetics (HR: 6.19; 95% CI: 1.59–24.07; p = 0.009), advance stage (HR: 9.24; 95% CI: 1.34–63.63; p = 0.024), and a high uric acid level (HR: 1.24; 95% CI: 1.00–1.54; p = 0.046) were correlated with a high mortality rate. Furthermore, by combining DE and the bulky disease, a specificity of 89.7% for DH prediction was achieved. In summary, DH genetics, not DE immunopositivity, is a poor prognostic factor for newly diagnosed DLBCL. A combination of bulky disease and a positive DE immunophenotype could facilitate DH genetics prediction in newly diagnosed DLBCL patients.
Simplified Model for Pre-Code RC Column exposed to Fire Followed by Earthquake
Authors: Ioannou Ioanna , Rossetto Tiziana , Rush David , Melo José 
Published: February 2022

Abstract
The behaviour of pre-code RC columns in sequence of fire and earthquake is not well understood and can be critical in case of buildings which experienced fire and are either unrepaired or poorly repaired when exposed to an earthquake. This study proposes a framework on how to construct a simplified model to assess the post-fire cyclic behaviour of such columns. Emphasis is given to the development of simplified material models which can be used to describe the performance of the confined concrete, as its post-fire behaviour is not well studied. The model’s performance is validated against the experimental results of a square, non-seismically designed RC column. Three scenarios are considered. The reference scenario, where the column is exposed only to cyclic loading. In the other two, the column is firstly exposed to an ISO-834 time-temperature curves in a furnace of 30min and 90min duration and after it cooled down, it is then exposed to cyclic loading. The results showed that simplified material models can be used to capture the post-fire cyclic behaviour of an RC column, built without seismic design. It was also found that the confined model adopted played an important role after the peak strength is reached.