bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chain-structure time-delay reservoir computing for synchronizing chaotic signal and an application to secure communication
Authors: Jin Leisheng , Liu Zhuo , Li Lijie 
Published: July 2022

AbstractIn this work, a chain-structure time-delay reservoir (CSTDR) computing, as a new kind of machine learning-based recurrent neural network, is proposed for synchronizing chaotic signals. Compared with the single time-delay reservoir, our proposed CSTDR computing shows excellent performance in synchronizing chaotic signal achieving an order of magnitude higher accuracy. Noise consideration and optimal parameter setting of the model are discussed. Taking the CSTDR computing as the core, a novel scheme of secure communication is further designed, in which the “smart” receiver is different from the traditional in that it can synchronize to the chaotic signal used for encryption in an adaptive manner. The scheme can solve the issues such as design constrains for identical dynamical systems and couplings between transmitter and receiver in conventional settings. To further manifest the practical significance of the scheme, the digital implementation using field-programmable gate array is conducted and tested experimentally with real-world examples including image and video transmission. The work sheds light on developing machine learning-based signal processing and communication applications.
Feasibility of a tele-prehabilitation program in high-risk patients with colon or rectal cancer undergoing elective surgery: a feasibility study
Authors: Franssen Ruud F. W. , Bongers Bart C. , Vogelaar F. Jeroen , Janssen-Heijnen Maryska L. G. 
Published: July 2022

AbstractBackgroundPrehabilitation appears to be an effective strategy to reduce postoperative complications and enhance recovery after colorectal surgery. Although many patients prefer (unsupervised) home-based prehabilitation, adherence can be problematic. Combining home-based prehabilitation with tele-monitoring might demonstrate a higher adherence than unsupervised prehabilitation; however, evidence on its feasibility and effectiveness in patients with colorectal cancer scheduled for elective surgery who are at high risk for postoperative complications is lacking. The aim of this study was to assess the feasibility of a bimodal tele-prehabilitation program in patients with colorectal cancer at high risk for postoperative complications.MethodsHigh-risk patients (oxygen uptake at the ventilatory anaerobic threshold ≤11 mL/kg/min or oxygen uptake at peak exercise ≤ 18 mL/kg/min) with colorectal cancer were included in a home-based bimodal tele-prehabilitation program. The program consisted of a personalized tele-monitored moderate to high-intensity interval training intervention and nutritional counseling. Feasibility was measured by participation rate, dropout rate, adherence to the physical exercise training session’s frequency, intensity, and time, and retention rate. Patient appreciation was measured by a patient appreciation questionnaire. Changes in preoperative physical fitness as secondary outcomes were quantified by time to exhaustion on a constant work rate (cycle) test, number of repetitions on the 30-s chair-stand test, and walking speed on the 4-m gait speed test.ResultsThe participation rate was 81%, there were no adverse events, and all participants managed to complete the tele-prehabilitation program (retention rate of 100%). Adherence with regard to the exercise program’s frequency, intensity, and time was respectively 91%, 84%, and 100%. All participants appreciated the tele-prehabilitation program. Time to exhaustion on the constant work rate test improved (not statistically significant) from a pre-prehabilitation median score of 317 seconds to a post-prehabilitation median score of 412 seconds (p= 0.24). Median number of repetitions on the 30-s chair-stand test improved from 12 to 16 (p= 0.01).ConclusionsTele-prehabilitation seems feasible in high-risk patients with colorectal cancer, but efforts should be made to further improve adherence to physical exercise training intensity. More research is needed to establish the (cost-)effectiveness of tele-prehabilitation regarding preoperative improvements in preoperative aerobic fitness and postoperative reduction of complications.Trial registrationISRCTN,ISRCTN64482109. Registered 09 November 2021 - Retrospectively registered.
Capacity utilization, factor substitution, and productivity growth in Canadian food processing sector
Authors: Gamtessa Samuel 
Published: July 2022

AbstractThe food processing industry has been confronted with unprecedented challenges as the costs of raw materials have risen rapidly, owing in part to the increased use of grains for ethanol. It is critical to comprehend how these trends affect the industry and potential coping techniques. This study estimates capacity utilization, which is a measurement that is well-suited to identify how input prices affect productivity in the short-run. The results show that capacity utilization decreased significantly after the year 2005 when raw materials input prices skyrocketed. TFP growth has also slowed significantly because of this. According to the estimated elasticities, the industry has little potential to deal with the cost challenge through factor substitution. Another conclusion is that capacity utilization has a positive elasticity with respect to the cost of raw materials. Because it is related to induced capital stock adjustment, which is only achievable in the long run, this is an indicator of how the industry will be affected in the long-run.
Supercarriers of antibiotic resistome in a world’s large river
Authors: Wang Jiawen , Pan Rui , Dong Peiyan , Liu Shufeng , Chen Qian , Borthwick Alistair G. L. , Sun Liyu , Xu Nan , Ni Jinren 
Published: July 2022

Abstract
Background
Antibiotic resistome has been found to strongly interact with the core microbiota in the human gut, yet little is known about how antibiotic resistance genes (ARGs) correlate with certain microbes in large rivers that are regarded as “terrestrial gut.”

Results
By creating the integral pattern for ARGs and antibiotic-resistant microbes in water and sediment along a 4300-km continuum of the Yangtze River, we found that human pathogen bacteria (HPB) share 13.4% and 5.9% of the ARG hosts in water and sediment but contribute 64% and 46% to the total number of planktonic and sedimentary ARGs, respectively. Moreover, the planktonic HPB harbored 79 ARG combinations that are dominated by “natural” supercarriers (e.g., Rheinheimera texasensis and Noviherbaspirillum sp. Root189) in river basins.

Conclusions
We confirmed that terrestrial HPB are the major ARG hosts in the river, rather than conventional supercarriers (e.g., Enterococcus spp. and other fecal indicator bacteria) that prevail in the human gut. The discovery of HPB as natural supercarriers in a world’s large river not only interprets the inconsistency between the spatial dissimilarities in ARGs and their hosts, but also highlights the top priority of controlling terrestrial HPB in the future ARG-related risk management of riverine ecosystems globally.
Long-term nitrogen deposition enhances microbial capacities in soil carbon stabilization but reduces network complexity
Authors: Ma Xingyu , Wang Tengxu , Shi Zhou , Chiariello Nona R. , Docherty Kathryn , Field Christopher B. , Gutknecht Jessica , Gao Qun , Gu Yunfu , Guo Xue , Hungate Bruce A. , Lei Jiesi , Niboyet Audrey , Le Roux Xavier , Yuan Mengting , Yuan Tong , Zhou Jizhong , Yang Yunfeng 
Published: July 2022

Abstract
Background
Anthropogenic activities have increased the inputs of atmospheric reactive nitrogen (N) into terrestrial ecosystems, affecting soil carbon stability and microbial communities. Previous studies have primarily examined the effects of nitrogen deposition on microbial taxonomy, enzymatic activities, and functional processes. Here, we examined various functional traits of soil microbial communities and how these traits are interrelated in a Mediterranean-type grassland administrated with 14 years of 7 g m−2 year−1 of N amendment, based on estimated atmospheric N deposition in areas within California, USA, by the end of the twenty-first century.

Results
Soil microbial communities were significantly altered by N deposition. Consistent with higher aboveground plant biomass and litter, fast-growing bacteria, assessed by abundance-weighted average rRNA operon copy number, were favored in N deposited soils. The relative abundances of genes associated with labile carbon (C) degradation (e.g., amyA and cda) were also increased. In contrast, the relative abundances of functional genes associated with the degradation of more recalcitrant C (e.g., mannanase and chitinase) were either unchanged or decreased. Compared with the ambient control, N deposition significantly reduced network complexity, such as average degree and connectedness. The network for N deposited samples contained only genes associated with C degradation, suggesting that C degradation genes became more intensely connected under N deposition.

Conclusions
We propose a conceptual model to summarize the mechanisms of how changes in above- and belowground ecosystems by long-term N deposition collectively lead to more soil C accumulation.
Barriers and opportunities to accessing social support in the transition from community to prison: a qualitative interview study with incarcerated individuals in Northern Norway
Authors: Solbakken Line Elisabeth , Wynn Rolf 
Published: July 2022

Abstract
Background
Incarcerated individuals have poor mental health compared to the general population. Social support has a beneficial effect on mental health. The buffering model proposes that social support facilitates coping under stressful conditions, while the main effects model suggests that belonging to social networks and having positive social interactions are beneficial for mental health. Prisons are a highly interesting context for studying social support, as imprisonment is perceived as stressful and disrupts social relationships and the availability of support. This study aims to explore incarcerated individuals' perceptions of social support from various sources in the transition from community to prison, its perceived significance for mental health, and the opportunities and barriers to accessing social support in a Norwegian prison context.

Methods
The experiences of eight incarcerated individuals from a prison in Northern Norway were gathered through conducting individual in-depth interviews. The data analysis was inspired by Charmaz’s version of Grounded Theory.

Results
Social support from peers was perceived to be important for the well-being and preserving of mental health in prison. Support from informal sources outside prison and prison officers were not granted the same significance by the participants. Although prison life was perceived as stressful, social support in the form of companionship, the feeling of belonging, shared activities, and everyday conversations were more important for the participants than support focusing on coping with the stress of incarceration.

Conclusions
Peers are perceived to be the most important source of social support, and vital for well-being and mental health in prison. Barriers to support from family, friends and prison officers may amplify the significance of support from peers.
A randomized, double-blind, phase III, non-inferiority clinical trial comparing the efficacy and safety of TA4415V (a proposed Trastuzumab biosimilar) and Herceptin (Trastuzumab reference product) in HER2-positive early-stage breast Cancer patients
Authors: Nodehi Reza Safaei , Kalantari Behjat , Raafat Jahangir , Ansarinejad Nafiseh , Moazed Vahid , Mortazavizadeh Seyed Mohammad Reza , Hosseinzadeh Mehran , Ghaderi Bayazid , Jenabian Arash , Qadyani Mojtaba , Haghighat Shirin , Allahyari Abolghasem , Mirzania Mehrzad , Seghatoleslami Mohammad , Payandeh Mehrdad , Alikhasi Afsaneh , Kafi Hamidreza , Shahi Farhad 
Published: July 2022

Abstract
Background
This study compared efficacy and safety of TA4415V, a trastuzumab biosimilar, with reference trastuzumab in patients with human epidermal growth factor receptor 2–positive (HER2-positive) early-stage breast cancer treated in the neoadjuvant setting in Iran.

Methods
Patients were randomly assigned to receive neoadjuvant TA4415V or reference trastuzumab concurrently with docetaxel (TH phase) for 4 cycles after treatment with 4 cycles of doxorubicin and cyclophosphamide (AC phase). Chemotherapy was followed by surgery. The primary endpoint was the comparison of pathologic complete response (pCR) rate in the per-protocol population. Secondary endpoints included comparisons of overall response rate (ORR), breast-conserving surgery (BCS), safety, and immunogenicity.

Results
Ninety-two participants were analyzed in the per-protocol population (TA4415V, n = 48; reference trastuzumab, n = 44). The pCR rates were 37.50% and 34.09% with TA4415V and reference drug, respectively. The 95% CI of the estimated treatment outcome difference (− 0·03 [95% CI − 0.23 to 0.16]) was within the non-inferiority margin. No statistically significant difference was observed between the groups for other efficacy variables in the ITT population: ORR (89.13% vs. 83.33%; p = 0.72) and BCS (20.37% vs. 12.96%; p = 0.42) in the TA4415V and reference drug group, respectively.
At least one grade 3 or 4 adverse events occurred in 27 (50%) patients in the TA4415V group versus 29 (53.70%) in the reference trastuzumab group (p = 0.70). The decrease in left ventricular ejection fraction (LVEF), as an adverse event of special interest (AESI) for trastuzumab, was compared between treatment groups in TH phase. Results demonstrated an LVEF decrease in 7 (12.96%) and 9 (16.67%) patients in TA4415V and reference trastuzumab groups, respectively (p = 0.59). Anti-drug antibodies (ADA) were not detected in any samples of groups.

Conclusions
Non-inferiority for efficacy was demonstrated between TA4415V and Herceptin based on the ratio of pCR rates in HER2-positive early breast cancer patients. In addition, ORR and BCS, as secondary endpoints, were not significantly different. Safety profile and immunogenicity were also comparable between the two groups.
Extrachromosomal circular DNA (eccDNA): an emerging star in cancer
Authors: Li Ruomeng , Wang Ying , Li Jing , Zhou Xikun 
Published: July 2022

AbstractExtrachromosomal circular DNA (eccDNA) is defined as a type of circular DNA that exists widely in nature and is independent of chromosomes. EccDNA has attracted the attention of researchers due to its broad, random distribution, complex biogenesis and tumor-relevant functions. EccDNA can carry complete gene information, especially the oncogenic driver genes that are often carried in tumors, with increased copy number and high transcriptional activity. The high overexpression of oncogenes by eccDNA leads to malignant growth of tumors. Regardless, the exact generation and functional mechanisms of eccDNA in disease progression are not yet clear. There is, however, an emerging body of evidence characterizing that eccDNA can be generated from multiple pathways, including DNA damage repair pathways, breakage-fusion-bridge (BFB) mechanisms, chromothripsis and cell apoptosis, and participates in the regulation of tumor progression with multiplex functions. This up-to-date review summarizes and discusses the origins, biogenesis and functions of eccDNA, including its contribution to the formation of oncogene instability and mutations, the heterogeneity and cellular senescence of tumor cells, and the proinflammatory response of tumors. We highlight the possible cancer-related applications of eccDNA, such as its potential use in the diagnosis, targeted therapy and prognostic assessment of cancer.
A practical workflow for the 3D reconstruction of complex historic sites and their decorative interiors: Florence As It Was and the church of Orsanmichele
Authors: Bent George R. , Pfaff David , Brooks Mackenzie , Radpour Roxanne , Delaney John 
Published: July 2022

Abstract
The Digital Humanities project Florence As It Was (http://florenceasitwas.wlu.edu) seeks to reconstruct the architectural and decorative appearance of late Medieval and early Modern buildings by combining 3D point cloud models of buildings (i.e. extant structures such as chapels, churches, etc.) with 3D rendered models of artworks that were installed inside them during the fourteenth and fifteenth centuries. This paper documents a novel bifurcated workflow that allows the construction of such integrated 3D models as well as an example case study of a church in Florence, Italy called Orsanmichele (https://3d.wlu.edu/v21/pages/orsanmichele2.html). The key steps worked out in the optimized workflow include: (1) art historical research to identify the original artworks in each building, (2) the use of LiDAR scanners to obtain 3D data (along with associated color information) of the interiors and exteriors of buildings, (3) the use of high resolution photogrammetry of works of art (i.e. paintings and sculptures) which have been removed from those buildings and are now in public collections, (4) the generation of point clouds from the 3D data of the buildings and works of art, (5) the editing and cojoining of a textured polygon model of artworks with a reduced size (using novel algorithms) point cloud model of the buildings in an open-source software tool called Potree so that artworks can be embedded in their original architectural settings, and (6) the annotation of these models with scholarly art historical texts that present viewers immediate access to information, archival evidence, and historical descriptions of these spaces. The integrated point cloud and textured models of buildings and artworks, respectively, plus annotations are then published with Potree. This process has resulted in the development of highly accurate virtual reconstructions of key monuments from the Florentine Middle Ages and Renaissance (like the fourteenth century building of Orsanmichele and the multiple paintings that were once inside it) as they originally appeared. The goal of this project is to create virtual models for scholars and students to explore research questions while providing key information that may assist in generating new projects. Such models represent a significant tool to allow improved teaching of art and architectural history. Furthermore, since the assigned location of some of the historic artworks within these sites are not always firmly known, the virtual model allows users to experiment with potential arrangements of objects in and on the buildings they may have originally decorated.
Predicting implementation of active learning by tenure-track teaching faculty using robust cluster analysis
Authors: Denaro Kameryn , Kranzfelder Petra , Owens Melinda T. , Sato Brian , Zuckerman Austin L. , Hardesty Rebecca A. , Signorini Adriana , Aebersold Andrea , Verma Mayank , Lo Stanley M. 
Published: July 2022

AbstractBackgroundThe University of California system has a novel tenure-track education-focused faculty position called Lecturer with Security of Employment (working titles: Teaching Professor or Professor of Teaching). We focus on the potential difference in implementation of active-learning strategies by faculty type, including tenure-track education-focused faculty, tenure-track research-focused faculty, and non-tenure-track lecturers. In addition, we consider other instructor characteristics (faculty rank, years of teaching, and gender) and classroom characteristics (campus, discipline, and class size). We use a robust clustering algorithm to determine the number of clusters, identify instructors using active learning, and to understand the instructor and classroom characteristics in relation to the adoption of active-learning strategies.ResultsWe observed 125 science, technology, engineering, and mathematics (STEM) undergraduate courses at three University of California campuses using the Classroom Observation Protocol for Undergraduate STEM to examine active-learning strategies implemented in the classroom. Tenure-track education-focused faculty are more likely to teach with active-learning strategies compared to tenure-track research-focused faculty. Instructor and classroom characteristics that are also related to active learning include campus, discipline, and class size. The campus with initiatives and programs to support undergraduate STEM education is more likely to have instructors who adopt active-learning strategies. There is no difference in instructors in the Biological Sciences, Engineering, or Information and Computer Sciences disciplines who teach actively. However, instructors in the Physical Sciences are less likely to teach actively. Smaller class sizes also tend to have instructors who teach more actively.ConclusionsThe novel tenure-track education-focused faculty position within the University of California system represents a formal structure that results in higher adoption of active-learning strategies in undergraduate STEM education. Campus context and evolving expectations of the position (faculty rank) contribute to the symbols related to learning and teaching that correlate with differential implementation of active learning.
Induction of severe hypoxemia and low lung recruitability for the evaluation of therapeutic ventilation strategies: a translational model of combined surfactant-depletion and ventilator-induced lung injury
Authors: Boerger Emilia , Russ Martin , von Platen Philip , Taher Mahdi , Hinken Lea , Pomprapa Anake , Koebrich Rainer , Konietschke Frank , Graw Jan Adriaan , Lachmann Burkhard , Braun Wolfgang , Leonhardt Steffen , Pickerodt Philipp A. , Francis Roland C. E. 
Published: July 2022

Abstract
Background
Models of hypoxemic lung injury caused by lavage-induced pulmonary surfactant depletion are prone to prompt recovery of blood oxygenation following recruitment maneuvers and have limited translational validity. We hypothesized that addition of injurious ventilation following surfactant-depletion creates a model of the acute respiratory distress syndrome (ARDS) with persistently low recruitability and higher levels of titrated “best” positive end-expiratory pressure (PEEP) during protective ventilation.

Methods
Two types of porcine lung injury were induced by lung lavage and 3 h of either protective or injurious ventilation, followed by 3 h of protective ventilation (N = 6 per group). Recruitment maneuvers (RM) and decremental PEEP trials comparing oxygenation versus dynamic compliance were performed after lavage and at 3 h intervals of ventilation. Pulmonary gas exchange function, respiratory mechanics, and ventilator-derived parameters were assessed after each RM to map the course of injury severity and recruitability.

Results
Lung lavage impaired respiratory system compliance (Crs) and produced arterial oxygen tensions (PaO2) of 84±13 and 80±15 (FIO2 = 1.0) with prompt increase after RM to 270–395 mmHg in both groups. After subsequent 3 h of either protective or injurious ventilation, PaO2/FIO2 was 104±26 vs. 154±123 and increased to 369±132 vs. 167±87 mmHg in response to RM, respectively. After additional 3 h of protective ventilation, PaO2/FIO2 was 120±15 vs. 128±37 and increased to 470±68 vs. 185±129 mmHg in response to RM, respectively. Subsequently, decremental PEEP titration revealed that Crs peaked at 36 ± 10 vs. 25 ± 5 ml/cm H2O with PEEP of 12 vs. 16 cmH2O, and PaO2/FIO2 peaked at 563 ± 83 vs. 334 ± 148 mm Hg with PEEP of 16 vs. 22 cmH2O in the protective vs. injurious ventilation groups, respectively. The large disparity of recruitability between groups was not reflected in the Crs nor the magnitude of mechanical power present after injurious ventilation, once protective ventilation was resumed.

Conclusion
Addition of transitory injurious ventilation after lung lavage causes prolonged acute lung injury with diffuse alveolar damage and low recruitability yielding high titrated PEEP levels. Mimicking lung mechanical and functional characteristics of ARDS, this porcine model rectifies the constraints of single-hit lavage models and may enhance the translation of experimental research on mechanical ventilation strategies.