bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for recurrence after Bankart repair: a systematic review and meta-analysis
Authors: Zhang Mingtao , Liu Jiaxin , Jia Yaofei , Zhang Guangrui , Zhou Jianping , Wu Ding , Jiang Jin , Yun Xiangdong 
Published: February 2022

Abstract
Background
The aim of this literature review was to identify preoperative risk factors associated with recurrent instability after Bankart repair.

Methods
The PubMed, Web of Science, Embase, and Cochrane Library databases were searched for potentially eligible articles. Two reviewers independently screened the titles and abstracts using prespecified criteria. Articles were included if they clearly stated the risk factors for recurrence after Bankart repair. Data on patient characteristics and recurrence rate were collected from each study. A random-effects model was used for the meta-analysis and the statistical analysis was performed using Review Manager 5.4 software.

Results
Nineteen studies that included 2922 participants met the inclusion criteria. The overall pooled prevalence of recurrent instability was 15.3% (range 6.9–42). The mean follow-up duration was 40.5 months (18–108). Twenty-one risk factors were identified, 10 of which were explored quantitatively. Statistically significant risk factors for recurrent instability following a Bankart procedure were age under 20 years (odds ratio [OR] 4.24, 95% confidence interval [CI] 2.8–96.23, p < 0.00001), a Hill-Sachs lesion (OR 3.61, 95% CI 2.06–6.33, p < 0.00001), a glenoid bone lesion (OR 2.8, 95% CI 1.96–4.01, p < 0.00001), shoulder hyperlaxity (OR 4.55, 95% CI 2.19–9.44, p < 0.0001), and an off-track lesion (OR 5.53, 95% CI 2.21–13.86, p = 0.0003). There was moderate evidence indicating that male sex (OR 1.6, 95% CI 1.07–2.37, p = 0.02) and playing contact sports (OR 1.54, 95% CI 0.96–2.45, p = 0.07) were further risk factors. Dominant side, a superior labrum from anterior to posterior (SLAP) lesion, and more than five preoperative dislocations were not found to be risk factors.

Conclusions
Patients younger than 20 years of age, a Hill–Sachs lesion, a glenoid bone lesion, shoulder hyperlaxity, and an off-track lesion appear to be significant predictors of recurrent instability following a Bankart procedure. Factors such as male sex and playing contact sports were associated with recurrent instability. Dominant side, a SLAP lesion, and more than five preoperative dislocations were not significant risk factors.
An evaluation of the feasibility of implementing a novel tobacco dependence treatment program for high-risk individuals into clinical practice within a community mental health center
Authors: Hogan Tory H. , Quisenberry Amanda , Breitborde Nicholas , Moe Aubrey , Ferketich Amy 
Published: February 2022

Abstract
Background
Individuals with serious mental illnesses experience deaths related to smoking at a higher prevalence than individuals without a psychotic-spectrum disorders. Traditional smoking cessation programs are often not effective among individuals with chronic mental disorders. Little is known about how to implement a tobacco cessation treatment program for this at-risk population within a community health center. The current study used qualitative methods to examine the factors that may enhance or impede the delivery of a novel tobacco cessation treatment for smokers with a psychotic-spectrum disorder diagnosis in an integrated care community health center.

Methods
Using a case study design, we conducted 22 semi-structured interviews with primary care providers, mental health providers, addiction counselors, case managers, intake specialists, schedulers, pharmacists, and administrative staff employed at the organization. Interviews were transcribed and themes were identified through a rich coding process.

Results
We identified environmental factors, organizational factors, provider factors and patient factors which describe the potential factors that may enhance or impede the implementation of a smoking cessation program at the integrated care community health center. Most notably, we identified that community mental health centers looking to implement a smoking cessation program for individuals with chronic mental health disorders should ensure the incentives for providers to participate align with the program’s objectives. Additionally, organizations should invest in educating providers to address stigma related to smoking cessation and nicotine use.

Conclusions
The findings of our study provide valuable insight for administrators to consider when implementing a smoking cessation program in an integrated care community health center. Our findings provide public health practitioners with potential considerations that should be discussed when designing and implementing a smoking cessation program for individuals with chronic mental disorders.
Fine-mapping of a putative glutathione S-transferase (GST) gene responsible for yellow seed colour in flax (Linum usitatissimum)
Authors: Young Lester , Akhov Leonid , Kulkarni Manoj , You Frank , Booker Helen 
Published: February 2022

Abstract
Objective
The brown seed coat colour of flax (Linum ustiatissimum) results from proanthocyanidin synthesis and accumulation. Glutathione S-transferases (GSTs), such as the TT19 protein in Arabidopsis, have been implicated in the transport of anthocyanidins during the synthesis of the brown proanthocyanidins. This study fine mapped the g allele responsible for yellow seed colour in S95407 and identified it as a putative mutated GST.

Results
We developed a Recombinant Inbred Line population with 320 lines descended from a cross between CDC Bethune (brown seed coat) and S95407 (yellow seed) and used molecular markers to fine map the G gene on Chromosome 6 (Chr 6). We used Next Generation Sequencing (NGS) to identify a putative GST was identified in this region and Sanger sequenced the gene from CDC Bethune, S95407 and other yellow seeded genotypes. The putative GST from S95407 had 13 SNPs encoding, including four non-synonymous amino acid changes, compared to the CDC Bethune reference sequence and the other genotypes. The GST encoded by Lus10019895 is a lambda-GST in contrast to the Arabidopsis TT19 which is a phi-GST.
Assessing the impact of different penalty factors of the Bayesian reconstruction algorithm Q.Clear on in vivo low count kinetic analysis of [11C]PHNO brain PET-MR studies
Authors: Ribeiro Daniela , Hallett William , Howes Oliver , McCutcheon Robert , Nour Matthew M. , Tavares Adriana A. S. 
Published: February 2022

Abstract
Introduction
Q.Clear is a Bayesian penalised likelihood (BPL) reconstruction algorithm available on General Electric (GE) Positron Emission Tomography (PET)-Computed Tomography (CT) and PET-Magnetic Resonance (MR) scanners. This algorithm is regulated by a β value which acts as a noise penalisation factor and yields improvements in signal to noise ratio (SNR) in clinical scans, and in contrast recovery and spatial resolution in phantom studies. However, its performance in human brain imaging studies remains to be evaluated in depth. This pilot study aims to investigate the impact of Q.Clear reconstruction methods using different β value versus ordered subset expectation maximization (OSEM) on brain kinetic modelling analysis of low count brain images acquired in the PET-MR.

Methods
Six [11C]PHNO PET-MR brain datasets were reconstructed with Q.Clear with β100–1000 (in increments of 100) and OSEM. The binding potential relative to non-displaceable volume (BPND) were obtained for the Substantia Nigra (SN), Striatum (St), Globus Pallidus (GP), Thalamus (Th), Caudate (Cd) and Putamen (Pt), using the MIAKAT™ software. Intraclass correlation coefficients (ICC), repeatability coefficients (RC), coefficients of variation (CV) and bias from Bland–Altman plots were reported. Statistical analysis was conducted using a 2-way ANOVA model with correction for multiple comparisons.

Results
When comparing a standard OSEM reconstruction of 6 iterations/16 subsets and 5 mm filter with Q.Clear with different β values under low counts, the bias and RC were lower for Q.Clear with β100 for the SN (RC = 2.17), Th (RC = 0.08) and GP (RC = 0.22) and with β200 for the St (RC = 0.14), Cd (RC = 0.18)and Pt (RC = 0.10). The p-values in the 2-way ANOVA model corroborate these findings. ICC values obtained for Th, St, GP, Pt and Cd demonstrate good reliability (0.87, 0.99, 0.96, 0.99 and 0.96, respectively). For the SN, ICC values demonstrate poor reliability (0.43).

Conclusion
BPND results obtained from quantitative low count brain PET studies using [11C]PHNO and reconstructed with Q.Clear with β < 400, which is the value used for clinical [18F]FDG whole-body studies, demonstrate the lowest bias versus the typical iterative reconstruction method OSEM.
Health-related quality of life of COVID-19 two and 12 months after intensive care unit admission
Authors: Demoule Alexandre , Morawiec Elise , Decavele Maxens , Ohayon Raphaelle , Malrin Roxane , Galarza-Jimenez Maria Alejandra , Laveneziana Pierantonio , Morelot-Panzini Capucine , Similowski Thomas , De Rycke Yann , Gonzalez-Bermejo Jesus 
Published: February 2022

Abstract
Purpose
To describe health-related quality of life (HRQoL) and dyspnea of COVID-19, 2 and 12 months after an intensive care unit (ICU) stay.

Methods
Patients discharged from the ICU between April and June 2020 and subsequently transferred to an inpatient rehabilitation facility were assessed 2 months and 12 months after ICU admission. HRQoL was assessed by the EuroQoL EQ-5D-3L (visual analog scale and time trade-off normalized to the French population algorithm) and dyspnea was assessed by the modified Medical Research Council (mMRC) dyspnea scale.

Results
We enrolled 94 patients. Median EQ-5D-3L time trade-off was 0.80 (interquartile range, 0.36–0.91) at 2 months and 0.91 (0.52–1.00) at 12 months (P = 0.12). EQ-5D-3L visual analog scale was 70 (60–85) at 2 months and 70 (60–85) at 12 months (P = 0.07). The mMRC dyspnea scale was 3 (2–4) at ICU discharge, 1 (0–2), P < 0.001 at 2 months and 1 (1–2) at 12 months. At 12 months, 68 (76%) patients reported at least one symptom that was not present prior to ICU admission and 27 (61%) of the 44 patients who were previously working had returned to work. On multiple linear regression, factors associated with EQ-5D-3L were body mass index on ICU admission, tracheostomy, male gender and active smoking.

Conclusions
Twelve months after ICU admission for COVID-19 and subsequent rehabilitation, a substantial proportion of patients reported alterations of HRQoL, dyspnea and symptoms that were not present prior to admission and a substantial proportion of these patients had not returned to work. Factors associated with a risk of poorer 12-month quality of life, may help to identify at-risk patients.
Range-Doppler domain spatial alignment for networked radars
Authors: Cong Xiaoyu , Han Yubing , Sheng Weixing , Guo Shanhong , Sun Hui 
Published: February 2022

AbstractAn important prerequisite for the radar network detection is that the measurements from local radars are transformed to a common reference frame without systematic or registration errors. For the signal level alignment, only partial signals are available for global decision-making due to power and bandwidth limitations. In this paper, a low-communication-rate spatial alignment in range-Doppler domain is proposed for networked radars without the prior spatial information (positions and attitudes) of radars, which is different from the existing methods in the trajectory domain or echo domain for alignment. To reduce the radar-to-fusion-center communication-rate, the method of initial constant false alarm rate detection is used to censor the signals in range-Doppler domain from local radars. Based on the spatial alignment model for the networked radars in geometry, a maximization problem is formulated. The objective function is the cross-correlation between the range-Doppler domain signals from different local radars. The optimization problem is solved by a genetic algorithm. Simulation results show that the rotation matrix and translation vector are estimated, and the detection probability of the proposed algorithm is improved after alignment and fusion compared with state-of-art methods.
Increasing loss of mature boreal forests around protected areas with red-listed forest species
Authors: Määttänen Aino-Maija , Virkkala Raimo , Leikola Niko , Heikkinen Risto K. 
Published: February 2022

Abstract
Background
Protected areas (PA) are central to biodiversity, but their efficiency is challenged by human-induced habitat loss and fragmentation. In the Fennoscandian boreal region, forestry with clearcutting is a threat to biodiversity causing the loss of mature forest elements and deterioration of ecological processes in forest landscapes, ultimately affecting PAs via declined structural connectivity. This paper aims to (1) determine PAs with high, red-listed species concentrations; (2) estimate the change in forest habitat around these PAs on different spatial scales; and (3) determine if forest management intensity is higher around biologically most valuable PAs. Occurrences of red-listed forest-dwelling species in Finland were used to identify PAs harbouring these species and to produce site-specific importance indices. CORINE landcover data was used as a baseline for the distribution of forests to assess the cover of clear-cuttings from 2001 to 2019 with the Global Forest Change (GFC) data set in three buffer areas around the PAs with occurrences of red-listed species.

Results
The largest proportion of clear-cuts occurred in 1 km and 10 km buffers around the PAs in the southern and middle boreal zones, being ca. 20%. This indicates that the forest habitat is degrading fast at regional and landscape levels. On the positive side, the change in forest cover was lower around the biologically most important PAs compared to other PAs with red-listed species.

Conclusions
Open and free satellite-data based assessments of the cover and change of forests provide reliable estimates about the rates at which mature and old-growth forests are being converted into young managed ones in Finland mainly via clear-cuts on different scales around PAs. The rate of clear-cuts was lowest in adjacent buffer areas next to the most species-rich PAs, which provides opportunities for biodiversity conservation efforts to be targeted to the remaining mature and old-growth forests found in the vicinity of these areas.
Finding the context indigenous innovation in village enterprise knowledge structure: a topic modeling
Authors: Kusumastuti Retno , Silalahi Mesnan , Asmara Anugerah Yuka , Hardiyati Ria , Juwono Vishnu 
Published: February 2022

AbstractIndigenous people have deep local knowledge of environmental sustainability and natural resource utilization, which are sources of innovations that often are drivers for economic growth in rural areas. This study explores the knowledge structure of indigenous innovation in village enterprises through content analysis of research publications. The resulting knowledge structure can be used to set up a roadmap for the studies on village enterprise and in a broader context to build metadata as a foundation for an evaluation system of village enterprise. The authors deploy topic modeling and co-word analyses to scrutinize 775 village enterprise research articles from the Scopus database and 665 paper from ScienceDirect. In the topic modeling, topic models village enterprises are setup. The topics found are local ownership (such as market and property), land, services (housing, health care), economy and public policy, financial service micro-credit, environmental pollution control, local business sustainability, social entrepreneurship, and household income, bioenergy based electrification, and bumdes management. Four sectors of the natural resource-based indigenous economy were identified: traditional food production, bio-energy for fuel and electricity, agriculture, and tourism. The topic models are used to comprehend knowledge structure in the village enterprises, whereby the focus is to uncover the context of indigenous village enterprise and its states of the art.
The OxyR and SoxR transcriptional regulators are involved in a broad oxidative stress response in Paraburkholderia xenovorans LB400
Authors: Méndez Valentina , Rodríguez-Castro Laura , Durán Roberto E. , Padrón Gabriel , Seeger Michael 
Published: February 2022

Abstract
Background
Aerobic metabolism generates reactive oxygen species that may cause critical harm to the cell. The aim of this study is the characterization of the stress responses in the model aromatic-degrading bacterium Paraburkholderia xenovorans LB400 to the oxidizing agents paraquat and H2O2.

Methods
Antioxidant genes were identified by bioinformatic methods in the genome of P. xenovorans LB400, and the phylogeny of its OxyR and SoxR transcriptional regulators were studied. Functionality of the transcriptional regulators from strain LB400 was assessed by complementation with LB400 SoxR of null mutant P. aeruginosa ΔsoxR, and the construction of P. xenovorans pIZoxyR that overexpresses OxyR. The effects of oxidizing agents on P. xenovorans were studied measuring bacterial susceptibility, survival and ROS formation after exposure to paraquat and H2O2. The effects of these oxidants on gene expression (qRT-PCR) and the proteome (LC–MS/MS) were quantified.

Results
P. xenovorans LB400 possesses a wide repertoire of genes for the antioxidant defense including the oxyR, ahpC, ahpF, kat, trxB, dpsA and gorA genes, whose orthologous genes are regulated by the transcriptional regulator OxyR in E. coli. The LB400 genome also harbors the soxR, fumC, acnA, sodB, fpr and fldX genes, whose orthologous genes are regulated by the transcriptional regulator SoxR in E. coli. The functionality of the LB400 soxR gene was confirmed by complementation of null mutant P. aeruginosa ΔsoxR. Growth, susceptibility, and ROS formation assays revealed that LB400 cells were more susceptible to paraquat than H2O2. Transcriptional analyses indicated the upregulation of the oxyR, ahpC1, katE and ohrB genes in LB400 cells after exposure to H2O2, whereas the oxyR, fumC, ahpC1, sodB1 and ohrB genes were induced in presence of paraquat. Proteome analysis revealed that paraquat induced the oxidative stress response proteins AhpCF and DpsA, the universal stress protein UspA and the RNA chaperone CspA. Both oxidizing agents induced the Ohr protein, which is involved in organic peroxide resistance. Notably, the overexpression of the LB400 oxyR gene in P. xenovorans significantly decreased the ROS formation and the susceptibility to paraquat, suggesting a broad OxyR-regulated antioxidant response.

Conclusions
This study showed that P. xenovorans LB400 possess a broad range oxidative stress response, which explain the high resistance of this strain to the oxidizing compounds paraquat and H2O2.
Approach to the Patient With Moderate Hypertriglyceridemia
Authors: Subramanian Savitha 
Published: February 2022

Abstract
Hypertriglyceridemia is a common lipid disorder encountered in clinical practice. Plasma triglycerides are a marker for the concentration of triglycerides carried in chylomicrons and very low-density lipoprotein particles. A fasting triglyceride level &lt;150 mg/dL is accepted widely as the upper limit of normal range. Guidelines for hypertriglyceridemia are variable without a global consensus on classification and goals for triglyceride levels. A general classification of hypertriglyceridemia is mild &lt; 200 mg/dL, moderate = 200 to 500 mg/dL, moderate to severe = 500 to 1000 mg/dL, and severe &gt; 1000 mg/dL. Because moderate hypertriglyceridemia does increase atherosclerotic cardiovascular disease risk, it is important to determine the underlying etiology to guide appropriate and timely management. This article provides stepwise recommendations on the diagnosis and management of moderate hypertriglyceridemia, based on 3 common scenarios encountered in clinical practice. Initial steps in management include evaluating for secondary contributors, especially diabetes mellitus. Based on patient characteristics, appropriate management decisions include lifestyle adjustments aimed at weight loss and decreasing alcohol consumption and use of statin and nonstatin therapies.
Impaired Metabolic Health and Low Cardiorespiratory Fitness Independently Associate With Subclinical Atherosclerosis in Obesity
Authors: Lehn-Stefan Angela , Peter Andreas , Machann Jürgen , Schick Fritz , Randrianarisoa Elko , Heni Martin , Wagner Robert , Birkenfeld Andreas L , Fritsche Andreas , Schulze Matthias B , Stefan Norbert , Kantartzis Konstantinos 
Published: February 2022

Abstract

Context
For a given body mass index (BMI), both impaired metabolic health (MH) and reduced cardiorespiratory fitness (CRF) associate with increased risk of cardiovascular disease (CVD).

Objective
It remains unknown whether both risk phenotypes relate to CVD independently of each other, and whether these relationships differ in normal weight, overweight, and obese subjects.

Methods
Data from 421 participants from the Tübingen Diabetes Family Study, who had measurements of anthropometrics, metabolic parameters, CRF (maximal aerobic capacity [VO2max]) and carotid intima-media thickness (cIMT), an early marker of atherosclerosis, were analyzed. Subjects were divided by BMI and MH status into 6 phenotypes.

Results
In univariate analyses, older age, increased BMI, and a metabolic risk profile correlated positively, while insulin sensitivity and VO2max negatively with cIMT. In multivariable analyses in obese subjects, older age, male sex, lower VO2max (std. ß −0.21, P = 0.002) and impaired MH (std. ß 0.13, P = 0.02) were independent determinants of increased cIMT. After adjustment for age and sex, subjects with metabolically healthy obesity (MHO) had higher cIMT than subjects with metabolically healthy normal weight (MHNW; 0.59 ± 0.009 vs 0.52 ± 0.01 mm; P &lt; 0.05). When VO2max was additionally included in this model, the difference in cIMT between MHO and MHNW groups became statistically nonsignificant (0.58 ± 0.009 vs 0.56 ± 0.02 mm; P &gt; 0.05).

Conclusion
These data suggest that impaired MH and low CRF independently determine increased cIMT in obese subjects and that low CRF may explain part of the increased CVD risk observed in MHO compared with MHNW.