bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical Ventilation and Hospital-Acquired Venous Thromboembolism Among Critically Ill Children
Authors: Sochet Anthony Alexander , Havlicek Elizabeth Ellen , Faustino E. Vincent S. , Goldenberg Neil Andrew 
Published: November 2022

OBJECTIVES
To estimate the occurrence of, and evaluate associations between, hospital-acquired venous thromboembolism (HA-VTE) and invasive mechanical ventilation (MV) among children hospitalized in the PICU.

METHODS
We performed a multicenter, retrospective cohort study comparing HA-VTE frequencies among subjects &lt;18 years of age hospitalized in the PICU from January 2018 through December 2019 among 47 participating centers, via the Pediatric Health Information Systems registry. We excluded perinatal encounters, those with VTE present at admission, and those with observational status. The primary outcome was the proportion of HA-VTE events before hospital discharge, including extremity deep venous thrombosis, pulmonary embolism, and organ-specific deep venous thrombosis. The HA-VTE frequencies were compared using χ2 tests. The association between HA-VTE and MV was investigated via multivariable logistic regression, adjusting for previously described VTE risk factors.

RESULTS
Of the 205 231 PICU encounters identified for study, 70 829 (34.5%) underwent MV. The occurrence of HA-VTE was 2.2% and was greater among children who received, versus did not receive, MV (4.4% versus 1.1%, P &lt; .001). Multivariable logistic regression revealed significant association between MV and HA-VTE (odds ratio 2.51, 95% confidence interval 2.33–2.69; P &lt; .001).

CONCLUSIONS
In this multicenter, retrospective, registry-based cohort study, HA-VTE were diagnosed in 2.2% of critically-ill children, and after adjustment for central venous catheterization, MV independently increased the risk of HA-VTE 2.5-fold. These findings warrant prospective validation to inform the design of future risk-stratified clinical trials of thromboprophylaxis in critically-ill children.
Masonería Hispana y sus luchas democráticas de José Antonio Ferrer Benimeli
Authors: Morales Ruiz Juan José 
Published: November 2022

Reseña del libro La Masonería Hispana y sus luchas democráticas. Sueños de libertad de José Antonio Ferrer Benimeli. Oviedo: masónica.es, 2022. 491páginas. ISBN: 978-84-19044-27-3.
Reseñado por Juan José Morales Ruiz
caso criminal masónico contra Luis Zuloaga, por infiel al Rito de York
Authors: Vázquez Semadeni María Eugenia 
Published: November 2022

Este trabajo analiza la profunda relación en México entre la masonería y la política tras la independencia. Este análisis de un juicio masónico contra un miembro de la logia “Apoteosis de Hidalgo,” en Chihuahua, ilustra cómo la masonería Yorkina en México se convirtió en un centro de acción política e incorporó elementos políticos en los principios y las prácticas masónicas. Influyó en las nuevas prácticas políticas republicanas, como las elecciones. También mostramos la importancia de la prensa y el debate público, así como la interacción entre la política local y la nacional, interacción a la contribuyeron las logias simbólicas locales.
II Seminario Permanente Internacional de Historia de las Masonerías
Authors: Sánchez Gálvez Samuel 
Published: November 2022

II Seminario Permanente Internacional de Historia de las Masonerías: Masonerías, mar y migraciones, Centro de Estudios Históricos de la Masonería Española (CEHME) de la Universidad de Zaragoza y con la colaboración de la Coordinación de Asuntos Internacionales y la Revista de Estudios Históricos de la Masonería Latinoamericana y Caribeña de la Sede del Pacífico de la Universidad de Costa Rica, la Fundación Joly Höhr de Cádiz, la Cátedra Internacional Historia de la Masonería Latinoamérica y Caribe “José Antonio Ferrer Benimeli” de la Universidad Autónoma de Zacatecas (México) y el Centro di Richerche Storiche Sulla Libera Muratoria de la Universidad de Turín (Italia), abril 29-mayo 2, 2022.
Social and Economic Factors of Violence Against Women in the South of Moldova: Identification, Estimation, and Mechanisms of Elimination
Authors: Bazueva Elena V. 
Published: November 2022

A surge in violence against women requires a better understanding of its causes and factors, which is the problem that this study seeks to address. This study aims to identify mechanisms through which these factors are reproduced on all levels of the gender system (individual, family, social milieu, professional milieu, state institutions). The focus is made on the case of the Autonomous Territorial Unit Gagauzia in Moldova. The study relies on systems analysis methods and approaches based on the institutional economic theory, systems theory and gender economics to assess the impact of socio-economic factors on the likelihood of intimate partner violence (IPV) in this region. In Gagauzia, there is a decline in women’s opportunities to realize their economic rights and ensure their financial independence. While the incomes of households are falling, gender discrimination, including physical violence, is perceived as justified by more and more people. Another contributing factor is the lack of effective mechanisms for IPV prevention. The factors contributing to IPV are related to the system of specialized institutions, which impose sanctions for violating the rules of gender stereotypical behavior. The study proposes a set of projects to promote more egalitarian norms on all levels of the gender system.
Composting as a sustainable alternative to eliminate household and similar Waste in developing countries
Authors: Bouadam Roukia , Zaidi Halima , Soukehal Imen , Makhloufi Sonia , Badreddine Hamada 
Published: November 2022

Purpose of study: The interest of this study is to show that the composting of various organic materials makes it possible to contribute to reducing the quantities of Waste sent to landfills and, consequently, the removal of their environmental impact. The aim is to show that aerobic composting of organic Waste can be an alternative to sustainable waste management in Algeria by examining the potential for producing compost from different organic waste streams.
Methodology: The method is based on analyzing documentary data, field surveys and experiments. The latter examines the potential for producing compost from different organic waste streams in Algeria. Three types of Waste are composted and analyzed: green Waste, kitchen waste and a combination. The experiment was carried out from March until June 2021; it involved using organic Waste to produce three different composts in their composition. Research has focused on studying the complex interplay between physical, chemical and biological factors that occur during composting and compost quality parameters.
Result: The results showed that composting the organic fraction of Waste reduced its mass by 22% for green Waste, 70% for kitchen waste and 63% for the mixture of the two. The variation of the process monitoring parameters (temperature, humidity, pH) corresponds perfectly to those established in previous studies. Through analysis and the germination test, the result has made it possible to obtain good-quality compost that can be used in agriculture.
Conclusion: The maturity of the composts obtained was checked by the germination test, demonstrating that the highest germination rate was recorded at the level of the soil-compost mixtures, regardless of the type of compost used. However, compost made from kitchen scraps alone has the highest rate. Chemical analyses of the composts confirmed these results, which are acceptable to French standards, given the lack of Algerian standards. This study demonstrates that composting has significantly reduced the Waste mass and obtained good quality compost.
DESENVOLVIMENTO E LINGUAGEM NA INFÂNCIA
Authors: Bortolanza Ana Maria Esteves 
Published: November 2022

A Política Nacional de Alfabetização atual impõe o método fônico como “única evidência científica” para alfabetização. Contrariamente, discute-se aqui os aspectos epistemológicos de desenvolvimento infantil e da linguagem. Parte de uma pesquisa (2017-2020), o estudo aborda as implicações epistemológicas, baseando-se em autores como Vygotsky, Luria, Leontiev, Bakhtin e outros. Em atividades para formar crianças como sujeitos de linguagem, o professor possibilita aprendizagens que impulsionam a formação das funções psíquicas superiores. Conclui-se que a linguagem exerce um papel fulcral no desenvolvimento infantil, cabendo à escola planejar e executar atividades com essa finalidade. À vista disso, é indispensável conhecer as implicações epistemológicas sobre desenvolvimento com foco na linguagem, tendo em vista a apropriação das máximas qualidades humanas pela criança.
A INSERÇÃO DOS BEBÊS NA EDUCAÇÃO INFANTIL EM UMA COMUNIDADE QUILOMBOLA DE MATO GROSSO
Authors: Silva Joice Ribeiro da , Mello Angela Rita Christofolo de 
Published: November 2022

Este artigo publiciza aspectos de uma pesquisa realizada no município de Poconé/Mato Grosso, no Distrito de Nossa Senhora Aparecida do Chumbo, na Creche Municipal Vovó Teófila. O seu objetivo foi compreender o processo de inserção dos bebês quilombolas e suas relações cotidianas nos espaços coletivos da creche e da comunidade, bem como, qual o entendimento dos moradores/familiares da comunidade acerca da presença dos bebês nesses espaços coletivos. A investigação se constituiu em uma pesquisa etnográfica, de abordagem qualitativa, que se valeu de observação in loco, com registros no diário de campo e de entrevistas realizadas com coordenadora, professores, pais e moradores desta comunidade. As informações foram sistematizadas de forma descritiva e analisadas de forma interpretativa. Os resultados permitem afirmar que a creche se constitui como um espaço de referência cultural, identitária e produtora de história, uma vez que os bebês que ali estão, participam ativamente desse processo. Assim, a comunidade caminha para uma mudança sobre a história de seu povo, construindo registros e preenchendo lacunas que caminham com a história do Distrito do Chumbo.
The development of reflection among future biology teachers in the process of methodological training
Authors: Sarimbayeva Balzat , Izbassarova Rimma , Semenikhina Svetlana , Semenikhin Viktor , Keubassova Gaukhar 
Published: November 2022

Methodical training is most effective, especially in biology, as in any field of education. It is important to determine the place of methodological education in pedagogical learning. It aims to form the opinions of future biology teachers about the methodological approach. In this study, which was developed at the University of Educational Sciences, studies were carried out for better education with students who teach biology. The methodological training of future biology teachers implies the acquisition of certain methodological knowledge. A qualitative method was used in this study, which was carried out with students who teach biology. The opinions of the pre-service teachers were detailed. Ethical approval was obtained from the university for this study, which was applied to 112 biology graduate candidates. The findings obtained from the research conducted with the content analysis method are stated and explained. From the research, it was concluded that the methodological approach is especially important for biology and that the arguments of the methodological approach should be understood in detail. It is included in the students’ results that the education subjects in the given university are prepared according to the access method.
Keywords: Education, methodology, teaching, content, biology teaching;
Formation of mathematical culture of students based on the solution of parametric problems
Authors: Pirmakhanbetovna Nurtayeva Karlygash , Kudiyarovich Ashirbayev Nurgali , Abilakimovna Aldibayeva Turagaldy , Torgayevna Shomanbayeva Manat 
Published: November 2022

The purpose of this research is to obtain the opinions of teachers in order to create a mathematical culture of students based on the solution of parametric problems. The qualitative research method was used in this study. The study group of the research consists of 40 mathematics teachers who teach at various high schools in Almaty, Kazakhstan. Research data were collected with a semi-structured interview form developed by the researchers. The research data were evaluated by using the content analysis method. As a result of the research, the majority of the mathematics teachers participating in the research stated that the students were insufficient in solving parametric problems. The vast majority of mathematics student teachers stated that they were very inadequate in posing parametric problems. The suggestions of the majority of the mathematics teachers participating in the research on the creation of a mathematics culture based on the solution of parametric problems are to create a technology-supported lesson environment, to conduct a needs analysis in the formation of the mathematics culture of the students and to provide in-service training to the teachers.
Keywords: Parametric problems, mathematics education, mathematics culture, teacher opinions
Organisational and pedagogical conditions of differentiated teaching of English to students
Authors: Otynshiyeva Malika , Uteubayeva Elmira , Turkenova Saltanat , Dybys Zhanserikova , Sevda R. Khudiyeva , Nazira Magzumova 
Published: November 2022

The aim of this study is to examine the relationship between the differentiation of teaching and pedagogical and technological decisions of university students. The differentiated teaching self-efficacy and pedagogical and technological competencies of students studying in foreign countries were studied. For this purpose, the pedagogical and technological relational learning of students studying English at the university was studied. This research was carried out with qualitative research design. A case study was conducted using the qualitative research method. This method was chosen to reveal the current situation. 82 university students were voluntarily selected as the study group. In this study, which was conducted in Kazakhstan in 2021–2022, the opinions of foreign students studying at the university with voice recorders were taken. In the study, three open-ended questions prepared by the researcher were asked. The data is thematised using the content analysis method and explained in detail. As a result of the research, it was concluded that differentiated teaching methods increase pedagogical competencies and that education with technological support is very important. Once again, it is seen that the problems experienced in teaching English are caused by teaching. It can be said that university students do not have enough knowledge about language teaching.
Keywords: English, differentiated instruction, proficiency, university, technology;
Performa Bank Wakaf Mikro Selama 2017-2021: Sebuah Studi Literatur Sistematis (Systematic Literature Review)
Authors: Athief Fauzul Hanif Noor , Rizki Darlin , Pratwindya Arum 
Published: November 2022

Penelitian ini bertujuan untuk mengetahui kinerja Bank Wakaf Mikro (BWM) sebagai lembaga pembiayaan sejak didirikan pada 2017 hingga saat ini. Penelitian ini termasuk penelitian kepustakaan dengan metode systematic literature review (SLR). Metode SLR digunakan untuk mengumpulkan, mengidentifikasi, menganalisa, bahkan melakukan telaah kritis terhadap sejumlah riset dengan bidang topik yang menarik, dengan pertanyaan penelitian yang relevan. Sumber data diperoleh dari database google, google scholar dan Garuda, yakni berupa penelitian dalam bentuk skripsi dan publikasi jurnal. Hasil dari penelitian ini terdapat dua bentuk apresiasi, yaitu Peran BWM terhadap pemberdayaan UMKM dan peran BWM terhadap masyarakat miskin. Sebanyak 14 penelitian memberikan apresiasi kepada BWM, yakni masyarakat dapat mengembangkan usahanya kembali dengan modal dari BWM. Terdapat empat aspek yang bisa di evaluasi yaitu: 1). Kurangnya jumlah sumber daya manusia, 2). Pendampingan usaha terhadap nasabah, 3). Sosialisasi terhadap nasabah, 4). Sosialisasi oleh pemerintah kepada masyarakat. Dari penelitian ini, dapat disimpulkan bahwa perlu ditingkatkan jumlah pengelola BWM agar dapat memberikan pendampingan usaha lebih maksimal serta melakukan sosialisasi edukasi mengenai bank wakaf mikro.
Pendampingan Penerapan Good Manufacturing Practice (GMP) Pada Usaha Jamu
Authors: Hapsari Yaning Tri , Kurniawanti Kurniawanti 
Published: November 2022

Konsumen semakin sadar dan peduli terhadap kualitas dan keamanan produk pangan. Untuk menjaga kualitas produk pangan yang dihasilkan dan dapat bersaing dengan industri sejenis serta mengurangi resiko dalam produksi perlu adanya persyaratan dasar yang harus dipenuhi pada suatu industri, seperti persyaratan produksi, persyaratan bangunan, lokasi, dan fasilitas serta peralatan produksi dan karyawan. Persyaratan tersebut dapat terpenuhi dengan penerapan GMP atau Good Manufacturing Practice.
Pengabdian ini penting untuk dilaksanakan dalam memastikan makanan yang dihasilkan sehat, aman, dan dapat dikonsumsi oleh masyarakat. Pelaksanaan pengabdian ini dengan cara melakukan pendampingan penerapan GMP untuk meningkatkan standar kualitas produk yang dihasilkan. Tujuan dari pengabdian ini adalah untuk membantu industri makanan dalam menerapkan GMP dalam pengolahan makanannya. Pelaksanaan pengabdian kepada masyarakat ini terdiri dari beberapa tahapan, antara lain: Observasi dan interview, analisis masalah, dan pendampingan penerapan GMP.
Usaha jamu merupakan industri yang bergerak di bidang makanan dan minuman. Dalam industri ini dituntut untuk tidak hanya menghasilkan produk yang enak di lidah tetapi juga harus memperhatikan kualitas produk yang dihasilkan. Pelaksanaan pendampingan ini semakin membantu mitra dalam menjaga kualitas produk yang dihasilkan. Sebelumnya mitra belum memiliki pengetahuan tentang GMP sehingga dengan adanya pendampingan ini mitra memahami prinsip-prinsip GMP, yaitu dalam hal keamanan dan kehigienisan produk sehingga layak dikonsumsi.
Sublethal Heat Treatment facilitates the progression of Glioma by inducing the P300-recruted β-catenin through activating the NF-κB pathway
Authors: Fu Huangde , Zeng Yile , Lai Jinqing , Lin Weibin , Chen Junyan , Xu Chaoyang , chen xiangrong , Tu Xiankun 
Published: November 2022

Abstract
Glioma is a neural malignant tumor that resistant to radiotherapy and chemotherapy, for which surgery is a challenge due to the unclear boundary between glioma tissues and normal brain tissues. Radiofrequency ablation (RFA) is a substitute technology of surgery widely applied in the treatment of solid malignant tumors. However, recently researches indicate that the progression of hepatocellular carcinoma can be facilitated RFA. The present study aims to check whether the progression of glioma can be facilitated by RFA and investigate the underlying mechanism. The sublethal heat, which is regularly detected in the marginal zones of RFA treatments, was utilized to mimic the effects of RFA on glioma cells. Firstly, we found that the 50℃ was the optimized condition in U251 cells and SNB19 cells, which was verified by increased MTT absorbance, promoted invaded cells, accelerated cell cycle, increased clone formation, and faster growth rate in xenograft animals. Subsequently, P300 was found dramatically upregulated in 50℃ treated glioma cells, the progression of which was abolished by the knockdown of P300. Survival analysis revealed that longer survival was observed in P300 knockdown glioma cells. Furthermore, the expression level of β-catenin and its several target genes were positively correlated with P300. TGF-β promoter could be precipitated by the antibody of both P300 and β-catenin in P300-overexpressed glioma cells. Additionally, NF-κB p65 level in the nucleus was positively correlated with P300 and p-IκB was significantly upregulated under the stimulation of the sublethal heat treatment, while the effects of sublethal heat treatment on glioma cells were abolished by the mutation of IκB. P300 was identified to be regulated by NF-κB in a transcriptional level. Lastly, we found that P300 was upregulated in RFA treated patients and RFA induced a shorten overall survival. Collectively, our data implied that sublethal heat treatment facilitated the progression of glioma by recruiting the β-catenin pathway through regulating the NF-κB/P300 axis.
Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M
Authors: Xiao Junyu , Ji Chenggong , Shen Hao , Su Chen , Li Yaxin , Chen Shihua , Sharp Thomas 
Published: November 2022

Abstract
Plasmodium falciparum causes the most severe malaria in humans. Immunoglobulin M (IgM) serves as the first line of humoral defense against infection and potently activates the complement pathway to facilitate P. falciparum clearance. A number of P. falciparum proteins hijack IgM, leading to immune evasion and severe disease. However, the underlying molecular mechanisms remain unknown. Here, using high-resolution cryo-electron microscopy, we delineate how P. falciparum proteins VAR2CSA, TM284VAR1, DBLMSP, and DBLMSP2 target IgM. Each protein binds IgM in a different manner, and together they present a variety of Duffy-binding-like domain-IgM interaction modes. We further show that these proteins interfere directly with IgM-mediated complement activation, with VAR2CSA exhibiting the most potent inhibitory effect. Structural analyses suggest that VAR2CSA occludes the congregation of the complement C1 complex on IgM. These results underscore the importance of IgM for human adaptation of P. falciparum and provide critical insights into its immune evasion mechanism.
The effect and safety of dexmedetomidine as an adjuvant to local anesthetics in erector spinae plane block: a systematic review and meta-analysis of randomized controlled trials
Authors: Yu Liang , Shen Xiaojuan , Liu He 
Published: November 2022

Abstract

Background:Dexmedetomidine (DEX) has been thought to be an effective adjuvant to local anesthetics (LAs) in erector spinae plane block (ESPB), however, this method of use is not recorded in the drug instructions. Hence, our meta-analysis will evaluate its efficacy and safety for the first time.Methods:A systematic search of published articles was conducted in the PubMed, Embase, Web of science, and Cochrane Library databases up to July 17, 2022, using specific keywords related to our aims. The time first to request rescue analgesia, number of patient controlled intravenous analgesia (PCIA) presses, rate of rescue analgesia use, postoperative nausea and vomiting (PONV), arrhythmia, and hypotension were calculated by using random-effect models. This systematic review and meta-analysis was registered with PROSPERO (registration number: CRD42022345488).Results:Numerous electronic databases were searched and finally 8 studies with a total of 570 patients, 303 in the DEX arm, 267 in the control arm were included. As an adjuvant to LAs, DEX significantly increased the time to first request of rescue analgesia (mean difference [MD] = 8.40, 95% confidence interval [CI] = 4.70-12.10,P< 0.00001), reduced the number of PCIA presses (MD = -4.12, 95% CI = -7.79 to -0.45,P= 0.03) and the rate of rescue analgesia (odds ratio [OR] = 0.33, 95% CI = 0.17-0.65,P= 0.002). Moreover, the combination reduced the risk of PONV (OR = 0.57, 95% CI = 0.36-0.91,P= 0.02). In addition, there was no difference in the incidence of hypotension (OR = 1.01, 95% CI = 0.37-2.74,P= 0.99) and arrhythmia (OR = 0.76, 95% CI = 0.19-3.07,P= 0.70).Conclusion:DEX can reduce analgesic requirements after various surgical procedures when used as an adjuvant to LAs for ESPB. Although, these non-significant differences in the safety profile (arrhythmia, hypotension) between the two groups.