bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subgroup detection-based dental caries status and inequalities trend exploration: A nationwide, 10-year-repeated cross-sectional study
Authors: He Jie , Liang Hongyuan , Kang Jian , Yuan Chao 
Published: August 2022

BackgroundThe goal of this study was to identify potentially important factors for the dental health though heterogeneous effects of risk factors within Chinese adolescent populations with different characteristics by analyzing the repeated cross-sectional data collected in the 3rd (2005) and 4th (2015) National Oral Health Survey.MethodsWe studied the relationships between the decayed, missing and filled permanent teeth (DMFT) score, which was a discrete value, with the caries risk factors (region, census type, gender, only child or not, parents' education level, tooth bushing, dentist visit history, knowledge score, sugar intake, and pit-and-fissure sealants status), though the Poisson mixture regression model, which could identify subgroups among the full population and estimate the heterogeneous effects of risk factors simultaneously. We performed a series of tests and trend analysis based on the model fitting results to explore the primary causes for the dental caries issue clearly and intuitively.ResultsA total of 39,049 teenagers aged 12 years were involved in the analysis. The Poisson mixture regression model clustered all individuals into three subgroups, where the mean values (standard deviations) of DMFT were 0.18 (0.56), 1.31 (1.49), and 2.91 (1.89), respectively. Model fitting results indicated that the heterogeneous effects of the involved risk factors were significant. In addition, we also found significant differences in the distributions and trends of DMFT within different categories of selected risk factors (region, census type, gender and dentist visiting history) from the projection analysis results. The estimated and projected proportions showed that the proportion of high caries risk population in the southwestern region increased by 31.8%, and will become even more severe as it will be the major component of high caries risk population in 2025.ConclusionsWe found that the trends for the developments and changes of dental caries within populations with different characteristics were inequality. The regional difference is the primary factor for diversified changes in DMFT. The findings in this study provide support for intervention and prevention policies for the deterioration of dental caries risk within different adolescent populations.
COVID-19 triggered a physically active lifestyle of people with cardiovascular diseases: Results of a small Austrian qualitative study
Authors: Krczal Eva , Hyll Walter 
Published: August 2022

ObjectiveThis paper explores physical activity patterns and compensation strategies of people with cardiovascular diseases. The aim is to provide insights into the factors and their relationships that may affect physical activity levels positively or negatively during the pandemic.MethodsWe adopted a qualitative approach with 35 participants who were purposively sampled from different provinces in Austria, including rural and urban areas. Semi-structured interviews were conducted during the second COVID-19 wave in autumn/winter 2020 and the fourth wave in autumn/winter 2021. Content analysis was applied to explore physical activity patterns, the perceived impact of the pandemic on physical activity as well as strategies adopted by participants to maintain physically active during the pandemic waves.ResultsResults show encouraging signs of a recovery or even increase in physical activity during the pandemic waves. The main drivers for maintaining or even increasing physical activity were intrinsic motivation and self-determined motivation relating to the pursue of individual health goals. Furthermore, analysis suggests a reinforcing effect of exercising in green natural areas by decreasing perception of effort and increasing motivation. There was also one group who experienced difficulties in adapting physical activity behaviors. Study participants who were used to exercise indoors struggled to replace accustomed activity patterns with alternatives that were not impacted by lockdown restrictions.ConclusionsThis study provides novel qualitative evidence on the effect of COVID-19 lockdowns on physical activity patterns of people with cardiovascular diseases. Public health interventions to enhance a physically active lifestyle during and beyond the COVID-19 pandemic are recommended to target moderate outdoor exercising and enhance adaptive capacities of people with cardiovascular diseases.
Development and comparison of predictive models for sexually transmitted diseases—AIDS, gonorrhea, and syphilis in China, 2011–2021
Authors: Zhu Zhixin , Zhu Xiaoxia , Zhan Yancen , Gu Lanfang , Chen Liang , Li Xiuyang 
Published: August 2022

BackgroundAccurate incidence prediction of sexually transmitted diseases (STDs) is critical for early prevention and better government strategic planning. In this paper, four different forecasting models were presented to predict the incidence of AIDS, gonorrhea, and syphilis.MethodsThe annual percentage changes in the incidence of AIDS, gonorrhea, and syphilis were estimated by using joinpoint regression. The performance of four methods, namely, the autoregressive integrated moving average (ARIMA) model, Elman neural network (ERNN) model, ARIMA-ERNN hybrid model and long short-term memory (LSTM) model, were assessed and compared. For 1-year prediction, the collected data from 2011 to 2020 were used for modeling to predict the incidence in 2021. For 5-year prediction, the collected data from 2011 to 2016 were used for modeling to predict the incidence from 2017 to 2021. The performance was evaluated based on four indices: mean square error (MSE), mean absolute error (MAE), and mean absolute percentage error (MAPE).ResultsThe morbidities of AIDS and syphilis are on the rise, and the morbidity of gonorrhea has declined in recent years. The optimal ARIMA models were determined: ARIMA(2,1,2)(0,1,1)12, ARIMA(1,1,2)(0,1,2)12, and ARIMA(3,1,2)(1,1,2)12 for AIDS, gonorrhea, and syphilis 1-year prediction, respectively; ARIMA (2,1,2)(0,1,1)12, ARIMA(1,1,2)(0,1,2)12, and ARIMA(2,1,1)(0,1,0)12 for AIDS, gonorrhea and syphilis 5-year prediction, respectively. For 1-year prediction, the MAPEs of ARIMA, ERNN, ARIMA-ERNN, and LSTM for AIDS are 23.26, 20.24, 18.34, and 18.63, respectively; For gonorrhea, the MAPEs are 19.44, 18.03, 17.77, and 5.09, respectively; For syphilis, the MAPEs are 9.80, 9.55, 8.67, and 5.79, respectively. For 5-year prediction, the MAPEs of ARIMA, ERNN, ARIMA-ERNN, and LSTM for AIDS are 12.86, 23.54, 14.74, and 25.43, respectively; For gonorrhea, the MAPEs are 17.07, 17.95, 16.46, and 15.13, respectively; For syphilis, the MAPEs are 21.88, 24.00, 20.18 and 11.20, respectively. In general, the performance ranking of the four models from high to low is LSTM, ARIMA-ERNN, ERNN, and ARIMA.ConclusionThe time series predictive models show their powerful performance in forecasting STDs incidence and can be applied by relevant authorities in the prevention and control of STDs.
Case report: Focal segmental glomerulosclerosis and nephrotic syndrome following treatment with pamidronate for calcitriol toxicity
Authors: Dawson Katherine Ann , Blong April , Walton Rebecca 
Published: August 2022

ObjectiveThis study aimed to describe a case of glomerulosclerosis resulting in nephrotic syndrome following the administration of pamidronate disodium to treat clinical calcitriol toxicity in a dog.Case summaryA 12-week-old intact male Labrador Retriever weighing 11.8 kg presented with lethargy and vomiting for 20 h after ingesting a 100 g tube of topical antipsoriatic cream (3 mcg/g of calcitriol; Vectical Ointment™, Galderma, Lausanne, Switzerland). Severe hypercalcemia was present on the day of the presentation. Hypercalcemia treatments such as saline diuresis, furosemide (Salix®, furosemide, Merck Animal Health, Kenilworth, NJ), and dexamethasone sodium phosphate (Dexamethasone SP, Mylan, Canonsburg, PA) were initiated. The dog was also administered a single dose of pamidronate disodium (Pamidronate disodium, Mylan, Canonsburg, PA) on the day of presentation. Initially, the patient's clinical signs improved, and the hypercalcemia resolved. Exactly 130 h post-pamidronate disodium (Dexamethasone SP, Mylan, Canonsburg, PA) administration, the patient developed biochemical abnormalities and severe edema, consistent with nephrotic syndrome, and was euthanized. Necropsy results revealed evidence of focal segmental glomerulosclerosis (FSGS).Unique informationPamidronate disodium, commonly used for the treatment of hypercalcemia, may have resulted in glomerulosclerosis and nephrotic syndrome in a dog with calcitriol toxicity. This complication should be taken into consideration when monitoring patients treated with pamidronate disodium for hypercalcemia.
An InN/InGaN quantum dot nonlinear constant phase element
Authors: Peng Yingchun , Xie Lingyun , Wang Jialin , Qin Ling , Nötzel Richard 
Published: August 2022

Abstract
InN/InGaN quantum dots (QDs) are found to establish a nonlinear constant phase element (CPE) response over a wide frequency range, measured by electrochemical impedance spectroscopy (EIS). The intrinsic surface donors together with the near-surface electron accumulation layer form the fractional capacitor. The magnitude of the impedance and the phase angle depend on the QD structural parameters and contact area. Importantly, they consistently change with applied voltage, constituting the nonlinear CPE response. A noise-filtering DC voltmeter with the phase angle as readout is proposed.
New Historicism in George Gissing’s The Odd Women
Authors: Al-abbasi Zahid Habeeb 
Published: August 2022

The Odd Women is a novel written by the English novelist George Robert Gissing in 1883. Gissing as a novelist was interested in feminist movement. Indeed, he supported women in his novel and based on his experience of the society in the 19th century, he wrote this novel. The novel illustrates how millions of women were considered as strange or odd because they were without pair or husband because they had to choose between their desires and their principles in life. Furthermore, Gissing attempts to portray to us the nature of women in relation to marriage and sexuality, and he depicts this through his characters in the novel. The novel gives vivid images to several issues dominant in the nineteenth century, such as women suffering the humiliation of being elderly and unmarried in the Victorian period, sexual anarchy and sex oppression, and women challenging the most deeply held attitudes and ideologies of the culture. In this paper, I am studying George Gissing in order to explain how sexuality and marriage were regarded in the Victorian period.
PERJANJIAN BERSAMA DALAM PENYELESAIAN SENGKETA HUBUNGAN INDUSTRIAL
Authors: Anshori Moch , Lutfi Anas , Syafrizal Syafrizal 
Published: August 2022

<p>Abstrak- Perselisihan Pemutusan hubungan kerja adalah perselisihan yang timbul<br />sebagai akibat tidak adanya kesesuaian pendapat mengenai pengakhiran<br />hubungan kerja yang dilakukan oleh salah satu pihak. Pemutusan hubungan<br />kerja (PHK), tidak saja diatur dalam UU No. 2 Tahun 2004, akan tetapi juga<br />dalam Undang-Undang No. 13 Tahun 2003 tentang Ketenagakerjaan. Rumusan<br />Masalah dalam penelitian ini adalah: Bagaimanakah keabsahan kesepakatan<br />dalam bentuk perjanjian bersama pengakhiran hubungan kerja ditinjau dari<br />peraturan perundangan dan yurisprudensi terhadap upaya penyelesaian<br />hubungan industrial non litigasi? Metode penelitian yang digunakan dalam<br />penelitian ini adalah metode penelitian hukum normatif. Teori yang digunakan<br />mengacu pada Teori Kebebasan Berkontrak dan Efektivitas Hukum. Kesimpulan<br />yang dihasilkan adalah bahwa Perjanjian Bersama yang sudah ditandatangani<br />tetapi belum didaftarkan ke pengadilan tidak dapat dibatalkan atau diingkari oleh<br />salah satu pihak. Karena Perjanjian Bersama mengikat para pihak bagai Undang<br />Undang.</p><p> </p><p>Kata Kunci: Perjanjian Bersama, Pemutusan Hubungan Kerja, Hubungan<br />Industrial.</p>
TECNOLOGIA DA INFORMAÇÃO EM SAÚDE E HOSPITAIS DIGITAIS
Authors: Silva Neto Raul Cardoso da 
Published: August 2022

Todos os anos, centenas de milhares de pacientes são vítimas de eventos adversos em hospitais no Brasil e no mundo, muitos sofrem danos irreversíveis e muitos outros vão a óbito, resultado de erros de conduta, falta de procedimentos, protocolos e diretrizes clínicas e principalmente a ausência de uma cultura de segurança do paciente.
Este estudo, realizado através de revisão bibliográfica, teve como objetivo demonstrar os benefícios que a tecnologia da informação em saúde e a implantação de processos digitais na operação de um hospital podem otimizar recursos, reduzir custos, aumentar o desempenho das equipes e, acima de tudo, promover o aumento na segurança do paciente. Este trabalho tem como base estudos bibliográficos e análise de casos.
Como principais resultados foi possível observar que através da tecnologia da informação aplicada a saúde, com a implementação de sistemas como prontuário eletrônico, sistemas de controle de administração de medicamentos, sistemas de apoio a decisão, diretrizes clínicas, etc. o índice de efeitos adversos relacionados a erros de medicação, reações adversas, entre outros, diminui consideravelmente, e o estabelecimento de protocolos e diretrizes apoiados pela tecnologia da informação aumentam a qualidade do tratamento proporcionado pelas equipes.
Faktor Risiko Kejadian Penyakit Kusta di Puskesmas Kotaraja
Authors: Tuturop Katarina Lodia , Adimuntja Natalia Paskawati , Borlyin Dian Eva 
Published: August 2022

Leprosy is a disease caused by Mycobacterium leprae. Which attacks various parts of the body. If left untreated, leprosy is very progressive causing damage to the skin, nerves, limbs and eyes. This study aims to determine the risk factors for the incidence of leprosy at the Kotaraja Public Health Center. This type of research is observational, with a case control study design. The population of the case group is people with leprosy and the population of the control group is neighbors with leprosy using purposive sampling technique, all populations in 2021. The sampling technique uses total sampling, the number of samples is 50 respondents with 1:1 criteria, namely 25 cases and 25 controls. Data were analyzed using the Odds Ratio (OR) test. The results showed that there was a risk between education level (OR= 11.1, 95% CI: 2.86-43.46) contact history (OR= 13.5 95% CI:1.55-117.13), regularity treatment (OR=6,68,95% CI: 1,76-25,24), family support (OR= 5,63, (95% CI:1,64-19,23) with the incidence of leprosy. While there is no risk between age (OR=0.47, 95% CI: 0.41-5.65) gender (OR=2.11, 95% Cl: 0.62-7.13) and the incidence of leprosy.
The Precise Location of the Stylomastoid Foramen and Clinical Implication for Facial Nerve Block
Authors: BABACAN Serdar , BAYAT Rohat , BÜYÜKFIRAT Evren , DENİZ Mustafa 
Published: August 2022

Aim: We aimed to develop linear regression formulas for determining the precise localization of the stylomastoid foramen on the base of the morphometric features of the person’s own skull.
Material and Method: The study was conducted on 22 stylomastoid foramina (11 skulls). The 10 parameters determined for the stylomastoid foramen were measured on the photographs taken from the skull base and the 17 parameters determined for the morphometric features of the skull were measured on the photographs taken from the anterior plane, lateral plane, and posterior plan using Image J measurement software. The data obtained were evaluated with SPSS 20.0 statistical software.
Results: To determine the morphometric and topographic features of the stylomastoid foramen the equations have been developed such as; P1 (The distance between stylomastoid foramen and root of the zygomatic arch)=18.758+(0.472xP12)-(2.092x P16)+(0.831xP17)–(0.390xP18)–(0.101x P20); Adjusted R2=0.865, Standard Error of the Estimation=1.389.
Conclusion: Mean values can give misleading information in determining the topographical relationship between the stylomastoid foramen and the surrounding anatomical structures. We have developed regression formulas that will estimate the accurate location of the stylomastoid foramen and the accurate distances between other surrounding anatomical structures, taking into account the morphometric characteristics of the person’s own skull.
Implicit Solar Coronal Magnetohydrodynamic (MHD) Modeling with a Low-dissipation Hybridized AUSM-HLL Riemann Solver
Authors: Wang Haopeng , Xiang Changqing , Liu Xiaojing , Lv Jiakun , Shen Fang 
Published: August 2022

Abstract
In this paper, we develop a 3D implicit single-fluid magnetohydrodynamic (MHD) model to simulate the steady-state solar corona with a wide range of Mach numbers and low plasma β. We employ a low-dissipation advection upstream splitting method (AUSM) to calculate the convective flux in the regions of low Mach numbers for a high resolution, and hybridize the AUSM with Harten-Lax-van Leer Riemann solver in the regions of high Mach numbers to improve the solver’s robustness. The inner boundary condition of no backflow is implemented by numerical flux. A reconstruction method based on the divergence-free radial basis function is adopted to enhance the divergence-free constraint of magnetic field. Also, an anisotropic thermal conduction term is considered; the positivity-preserving reconstruction method is used to prevent the presence of negative thermal pressure and plasma density, and the implicit lower-upper symmetric Gauss Seidel method is implemented for a better convergence rate. After establishing the implicit solar wind MHD model, we employ it to simulate steady-state solar coronal structures in Carrington rotations 2177 and 2212. The simulations demonstrate that the MHD model’s computational efficiency is desirable, and the modeled results are basically in agreement with the solar coronal observations and the mapped in situ measurements from the OMNI archive. Consequently, this implicit MHD model is promising to simulate a complex plasma environment with high-intensity magnetic field and wide-ranging Mach numbers.
Fermi LAT Gamma-ray Detection of the Recurrent Nova RS Ophiuchi during its 2021 Outburst
Authors: Cheung C. C. , Johnson T. J. , Jean P. , Kerr M. , Page K. L. , Osborne J. P. , Beardmore A. P. , Sokolovsky K. V. , Teyssier F. , Ciprini S. , Martí-Devesa G. , Mereu I. , Razzaque S. , Wood K. S. , Shore S. N. , Korotkiy S. , Levina A. , Blumenzweig A. 
Published: August 2022

Abstract
We report the Fermi LAT γ-ray detection of the 2021 outburst of the symbiotic recurrent nova RS Ophiuchi. In this system, unlike classical novae from cataclysmic binaries, the ejecta from the white dwarf form shocks when interacting with the dense circumstellar wind environment of the red giant companion. We find the LAT spectra from 50 MeV to ∼20–23 GeV, the highest-energy photons detected in some subintervals, are consistent with π
0-decay emission from shocks in the ejecta as proposed by Tatischeff & Hernanz for its previous 2006 outburst. The LAT light curve displayed a fast rise to its peak >0.1 GeV flux of ≃6 × 10−6 ph cm−2 s−1 beginning on day 0.745 after its optically constrained eruption epoch of 2021 August 8.50. The peak lasted for ∼1 day and exhibited a power-law decline up to the final LAT detection on day 45. We analyze the data on shorter timescales at early times and found evidence of an approximate doubling of emission over ∼200 minutes at day 2.2, possibly indicating a localized shock-acceleration event. Comparing the data collected by the American Association of Variable Star Observers, we measured a constant ratio of ∼ 2.8 × 10−3 between the γ-ray and optical luminosities except for a ∼5×smaller ratio within the first day of the eruption likely indicating attenuation of γ rays by ejecta material and lower high-energy proton fluxes at the earliest stages of the shock development. The hard X-ray emission due to bremsstrahlung from shock-heated gas traced by the Swift-XRT 2–10 keV light curve peaked at day ∼6, later than at GeV and optical energies. Using X-ray derived temperatures to constrain the velocity profile, we find the hadronic model reproduces the observed >0.1 GeV light curve.
Efficacy and safety of folfiri plus aflibercept in second-line treatment of metastatic colorectal cancer
Authors: Erol Cihan , Nahit Sendur Mehmet Ali , Bilgetekin Irem , Garbioglu Duygu Bayir , Hamdard Jamshid , Akbas Sinem , Hizal Mutlu , Arslan Cagatay , Sevinc Alper , Kucukarda Ahmet , Erdem Dilek , Kahraman Seda , Cakir Emre , Demirkiran Aykut , On Sercan , Dogan Izzet , Erdogan Atike Pinar , Koca Sinan , Kubilay Pinar , Eren Orhan Onder , Cilbir Ebru , Celik Emir , Araz Murat , Ozyukseler Deniz Tataroglu , Yildirim Mahmut Emre , Bahceci Aykut , Taskaynatan Halil , Oyman Abdilkerim , Deniz Gulhan Ipek , Menekse Serkan , Kut Engin , Gulmez Ahmet , Sakin Abdullah , Nayir Erdinc , Acar Ramazan , Sen Erdem , Inal Ali , Turhal Serdar , Kaya Ali Osman , Paydas Semra , Tastekin Didem , Hacibekiroglu Ilhan , Cincin Irfan , Bilici Ahmet , Mandel Nil Molinas , Dede Didem Sener , Akinci Muhammed Bulent , Oksuzoglu Berna , Uncu Dogan , Yalcin Bulent , Artac Mehmet 
Published: August 2022

Aims:
The addition of aflibercept to the fluorouracil and irinotecan (FOLFIRI) regimen significantly improved clinical outcomes in patients with metastatic colorectal cancer (CRC) previously treated with oxaliplatin. We aimed to investigate the efficacy and safety of second-line FOLFIRI and aflibercept combination in patients with metastatic CRC in real-life experience.

Materials and Methods:
Four hundred and thirty-three patients who treated with FOLFIRI and aflibercept in the second-line were included in the study. The clinical and pathological features of the patients were recorded retrospectively. Survival (overall and progression-free survival [PFS]), response rates, and safety data were analyzed.

Results:
The median age was 61. Majority of patients (87.5%) received first-line bevacizumab and 10.1% of patients received anti-epidermal growth factor receptor agents. About 80% of patients had KRAS, 18.6% of patients had NRAS, and 6.4% of patients had BRAF mutations. The median OS was 11.6 months (95% confidence interval [CI], 10.6–12.6) and the median PFS was 6 months (95% CI, 5.5–6.5). About 4.6% of patients had complete response and 30.6% of patients had partial response as best tumor response. Grade 1–2 toxicities were seen in 33.4% of patients, while grade 3–4 toxicities were recorded in 27% of patients. Eight patients (2%) died due to treatment toxicity.

Conclusions:
Overall and PFS were similar in routine clinical practice compared to phase III pivotal VELOUR trial. However, response rates were found to be higher. It was observed that there were fewer adverse events compared to the VELOUR trial.