bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors and diagnostic value of urinary N-terminal pro-brain natriuretic peptide for verification of heart failure in human immunodeficiency virus-infected patients
Authors: Goryacheva O. G. , Koziolova N. A. 
Published: March 2022

Aim. To determine the risk factors and diagnostic value of urinary N-terminal probrain natriuretic peptide (NT-proBNP) for verification of heart failure in human immunodeficiency virus (HIV)-infected patientsMaterial and methods. This cross-sectional screening clinical trial included 115 HIV-infected patients who were hospitalized during 24 months. The patients were divided into 2 groups, depending on the data suggestive of HF and the blood and urinary NT-proBNP concentration. So, group 1 included 69 HIV-infected patients with HF symptoms and increased blood and urinary NTproBNP, while group 2 — 46 HIV-infected patients not meeting HF criteria. NTproBNP concentration was determined on Immulite 1000 Immunoassay System (DPC, USA) in blood plasma and frozen urine using Vector Best reagents (Russia).Results. Correlation analysis revealed a significant direct moderate correlation between blood and urinary NT-proBNP in the entire cohort of studied patients (r=0,367; p<0,05). Urinary NT-proBNP ≥8,6 pg/ml ml is diagnostic for HF verification in HIV-infected patients. Significant differences between the groups were obtained in the incidence of ventricular arrhythmias, viral hepatitis B and C, liver cirrhosis, infective endocarditis, other inflammatory diseases, thrombocytopenia, left ventricular (LV) diastolic dysfunction and its severity. In addition, there were differences in LV mass index, left atrial volume index, incidence of LV hypertrophy and left atrial enlargement, concentration of hemoglobin and CD4 cells <200 in 1 µl. The preserved LV ejection fraction was detected significantly more often (p<0,001). Conclusion. In HIV-infected patients, blood plasma and urinary NT-proBNP concentration correlates with each other. Urinary NT-proBNP ≥8,6 pg/ml is diagnostic for HF verification in HIV-infected patients. Risk factors and features of developing HF, estimated by NT-proBNP concentration in frozen urine in HIV-infected patients, are comparable to data obtained from blood plasma NTproBNP.
Contribution of inflammation to heart failure development in human immunodeficiency virus-infected patients
Authors: Koziolova N. A. , Goryacheva O. G. , Litsinger I. F. 
Published: March 2022

Aim. To determine the peculiarities of heart failure (HF) development in human immunodeficiency virus (HIV)-infected patients, depending on the blood concentration of C-reactive protein (CRP).Material and methods. This cross-sectional screening clinical trial included 100 patients hospitalized with HIV infection and a history of HF for 28 months. The patients were divided into 2 groups depending on blood CRP concentration. The cut-off point was CRP of 15 mg/l. The first group included 37 HIV-infected patients with HF and blood CRP <15 mg/l, while the second group — 63 HIV-infected patients with HF and CRP concentration ≥15 mg/l. The inclusion criteria were HIV infection and prior HF, stable medical state, taking into account the underlying disease that required hospitalization. The study did not include patients with acute cardiovascular diseases within prior 3 months, acute decompensated and acute heart failure, cancer, infectious diseases, conditions that required surgical intervention. N-terminal pro-brain natriuretic peptide (NT-proBNP) was determined in all patients.Results. Correlation analysis revealed a strong inverse relationship between the blood concentrations of NT-proBNP and CRP (r=-0,639; p<0,005). A ROC curve revealed the most optimal cut-off threshold of 9,8 mg/l (AUC=0,796, p<0,05), which ensures sensitivity of 92,9% (p<0,05) and specificity of 57,6% (p<0,05). The odds ratio (OR) of an increase in NT-proBNP >450 pg/ml, and hence the risk of acute decompensated HF in the presence of a CRP concentration of 1-9,8 mg/l in HIV-infected patients with HF was 44,73 (95% CI=8,62;311,10), while relative risk (RR) — 18,73 (95% CI=4,94;112,94). In the presence of in hospital inflammatory diseases and CRP ≥15 mg/l in HIV-infected patients and prior HF, the RR of acute decompensated HF is reduced by 88% (RR=0,12, 95% CI=0,03-0,33).Conclusion. CRP values from 1 to 9,8 mg/l in HIV-infected patients with HF are predictors of its severity, characterized by a higher incidence of HF with reduced ejection fraction, diastolic dysfunction and left ventricular hypertrophy without significant differences with patients who have CRP >9,8 mg/l. CRP concentration >9,8 mg/l in HIV-infected patients and prior HF indicates the development of an inflammatory process, and not a worsening of the HF course.
AVALIAÇÃO DA FORMAÇÃO MÉDICA PARA A APS: PERCEPÇÕES DE EGRESSOS DE UMA UNIVERSIDADE PÚBLICA
Authors: Souza Torres Ana Carolina , Mota Maria Vaudelice , De Sousa Maria do Socorro , Fraxe Pessoa Sarah Maria , Marques Ávila Maria Marlene 
Published: March 2022

Esse estudo buscou avaliar a formação médica na perspectiva da Atenção Primária à Saúde (APS) com base nas percepções dos egressos do curso de Medicina da Universidade Federal do Ceará, à luz das Diretrizes Curriculares Nacionais e dos eixos do Pró-Saúde. Pesquisa qualitativa, desenvolvida no período de setembro de 2015 a junho de 2016, na Rede de APS da cidade de Fortaleza-CE. Os informantes foram 10 médicos egressos do curso graduados entre 2003 e 2011. Realizou-se entrevistas semiestruturadas, transcritas e analisadas pela técnica da Análise Temática. A análise evidenciou como fragilidades na formação: pedagogia tradicional dos docentes no módulo de Assistência Básica em Saúde (ABS); descontinuidade nas disciplinas de ABS em relação à inserção dos discentes no cenário de práticas da Estratégia Saúde da Família (ESF); poucos docentes e preceptores com especialização em Medicina de Família na condução do módulo; deficiente Integração Ensino-Serviço, ações de Educação Permanente desconectadas das necessidades dos profissionais e da comunidade. Como potencialidades: a prática no território da ESF é potente transformadora da formação, e as vivências em cenários de práticas diversificados, propiciados sobretudo pelos projetos de extensão, PET-Saúde, e pelo movimento estudantil agregaram à formação competências para atuar na APS, capacidade crítico-reflexiva e alinhamento ao princípio da integralidade. Nossa pesquisa pode contribuir no processo de reflexão-ação visando aperfeiçoar o processo formativo de profissionais médicos para atuação na APS.
Análise do processo ensino-aprendizagem pela ótica de preceptores de graduação no âmbito da Atenção Primária à Saúde
Authors: Pereira Afonso Luís Puig , Zilbovicius Celso , Carnut Leonardo , Souza Neto Antonio Carlos , Teixeira Vilhena Lopes Tarsila , Navarrete Ramon 
Published: March 2022

Introdução: A preceptoria é um importante elo pedagógico na integração ensino-serviço-gestão-comunidade. Dentre muitas tensões que esses profissionais sofrem na Atenção Primária à Saúde eles são instigados diariamente sobre quais métodos de ensino e avaliação podem e/ou devem ser utilizados para um adequado aprendizado dos estudantes. Assim, o objetivo deste estudo é conhecer o processo ensino-aprendizagem vivenciado pelos profissionais que atuam como preceptores de alunos de graduação no âmbito da Atenção Primária à Saúde, no município de São Paulo.Metodologia: Trata-se de um estudo analítico-interpretativo de abordagem qualitativa. Após aplicação de questionário sócio demográfico realizou-se entrevistas semiestruturadas com 14 preceptores interpretados pela análise de conteúdo temática.Resultados: Da análise, emergiram as categorias “estratégias e métodos de ensino” e “avaliação do processo ensino-aprendizagem”. O processo ensino-aprendizagem é guiado especialmente pela rotina da Atenção Primária à Saúde e pela prática, sendo a metodologia de ensino mais frequente porém não problematizada. Os métodos ativos de ensino são aplicados por aqueles que possuem algum tipo de formação pedagógica. Os processos avaliativos apresentaram-se incipientes e causam insegurança nos preceptores. Conclusão: Formar profissionais que exercem a preceptoria é essencial para compor um perfil pedagógico adequado, fomentando no profissional seu papel de educador e instrumentalizando-os de ferramentas metodológicas e avaliativas.
Repasses financeiros para serviços de fisioterapia ambulatorial no SUS em macrorregiões de saúde da Bahia
Authors: Aleluia Ítalo Ricardo Santos , Fontoura Fabiane Costa Santos , De Santana Anderson Freitas , Montenegro Bruno Do Nascimento 
Published: March 2022

Esse estudo analisou os repasses financeiros para serviços de fisioterapia ambulatorial do SUS em macrorregiões de saúde do estado da Bahia e discute os possíveis motivos que influenciam esses repasses. Trata-se de estudo ecológico com dados do Sistema de Informação Ambulatorial do SUS. Considerou-se o período de dez anos (2009 a 2019) e os seguintes estratos de comparação: o estado, as macrorregiões de saúde, os anos da série temporal e a tipologia do prestador (público e privado). Calculou-se a diferença de valor bruto (em reais) e o percentual, além da despesa aprovada por 1.000 habitantes para cada macrorregião. A maior produção ambulatorial e repasses financeiros com atendimentos de fisioterapia, no período, concentraram-se nas macrorregiões Leste e Sul da Bahia. A despesa aprovada por 1.000 habitantes teve variação negativa de 8% para todo o estado. Os atendimentos fisioterapêuticos demandaram repasses importantes do SUS em todas as regiões analisadas, com comportamento heterogêneo dos valores entre elas. Havia importante diferença entre os valores cobrados pelos prestadores para custeio pelo SUS, com aqueles efetivamente repassados para pagamento em quase todas as macrorregiões, sendo boa parte dos repasses destinada para os estabelecimentos privados contratualizados. Destacamos a necessidade de ampliação de serviços ambulatoriais de fisioterapia próprios do SUS visando inverter a lógica dominante do financiamento de serviços contratualizados.
The Inhibitory Effect of Thioridazine on adeB Efflux Pump Gene Expression in Multidrug-Resistant Acinetobacter baumannii Isolates Using Real Time PCR
Authors: Ahmadi Fereshteh , Khalvati Bahman , Eslami Saba , Mirzaii Mehdi , Roustaei Narges , Mazloomirad Farzad , Khoramrooz Seyed Sajjad 
Published: March 2022

Background: The purpose of the present study was to investigate the antimicrobial effects of berberine and thioridazine, as well as their effect on the gene expression of the AdeABC efflux pump system in Multidrug-Resistant (MDR) Acinetobacter baumannii (A. baumannii) isolates.
Methods: This study was carried out in five MDR clinical isolates of A. baumannii and a sample of standard strain (A. baumannii PTCC1797). The effect of Minimum Inhibitory Concentration (MIC) and the Minimum Bactericidal Concentration (MBC) of berberine, thioridazine, and ciprofloxacin alone and their combination on A. baumannii was evaluated by broth microdilution method. Also, their effect on the expression of adeB efflux pump gene was evaluated using real time PCR method.
Results: The MIC of thioridazine, berberine, ciprofloxacin+thioridazine, ciprofloxacin+berberine, thioridazine+berberine, and ciprofloxacin+thioridazine+berberine on MDR A. baumannii isolates was 64, 256, 128, 256, 128, and 128 μg/ml, respectively. The results showed that treatment of strains with thioridazine alone and in combination with berberine and ciprofloxacin significantly (p<0.05) decreased the expression of adeB efflux pump gene.
Conclusion: Due to the inhibitory effects of thioridazine on bacterial isolates and adeB efflux pump gene, this compound can be used as a potential antimicrobial agent against MDR A. baumannii.
Strong Association of Polymorphism in SPRED2 Gene with Disease Susceptibility and Clinical Characteristics of Rheumatoid Arthritis in the Iranian Population
Authors: Pakzad Bahram , Moghadammanesh Hamed , Salesi Mansour , Salehi Rasoul 
Published: March 2022

Background: The high heritability of Rheumatoid Arthritis (RA) has been estimated from different studies. Recently, Genome-Wide Association Studies (GWAS) show a large number of Single Nucleotide Polymorphisms (SNPs) loci affecting susceptibility to RA. The rs934734 polymorphism in the SPRED2 gene is one of these loci. Studies have shown that the SPRED2 gene is involved in the regulation of inflammatory response, leukocyte infiltration, and local chemokine production. In the current study, the possible association between SNP rs934734 (intronic variant) in the SPRED2 gene with RA risk in the Iranian population was evaluated.
Methods: One hundred fourteen RA patients and 120 healthy counterparts were recruited in this case-control study to evaluate rs934734 genotypes using the real-time PCR High Resolution Melting method (HRM).
Results: Logistic regression analysis demonstrated that GG and AG genotypes compared with AA genotype increase the risk of RA (GG vs. AA; OR=4.61; 95%CI [2.21-9.35]; p<0.001 and AG vs. AA; OR=2.54; 95%CI [1.36-4.76]; p=0.004). Furthermore, subjects with allele G were more frequently affected with RA than subjects with A allele (OR=2.33; 95%CI [1.61-3.38]; p<0.001). Besides, in the patient group, there was a significant correlation between Erythrocyte Sedimentation Rate (ESR) and C-reactive protein (CRP) concentration with rs934734 polymorphism (p<0.05).
Conclusion: Our findings suggest that rs934734 in SPRED2 strongly underlies RA development and is associated with clinicopathological characteristics of this disease.
Evaluation of NKILA lncRNA and NFκB Genes Expression in an Iranian Gastric Cancer Patient Compared with Healthy Tissue and the Relationship between Clinicopathological Features
Authors: Soltani Negar , Pishkar Leila , Vahid Chaleshi 
Published: March 2022

Background & Objective: Long non-coding RNAs play critical roles in the initiation and development of gastric cancer (GC). The aim of this study was to assess the expression of NKILA and NFKB genes and the relationship between their expressions with clinical characteristics in gastric cancer. Also, relative expression of lncRNAsNKILA, compared NFKB in GC tissues was evaluated.
Materials & Methods: This cross-sectional study was performed on 50 gastric formalin-fixed paraffin-embedded tumor tissue samples and 50 normal tissues. The RNA level of lncRNAsNKILA and NFKB genes was assessed using the quantitative real-time polymerase chain reaction. B2M was used as an internal control. The 2 -ΔΔCq method was used to determine the expression fold changes.
Results: A significant association was observed between the levels of NKILA, in gastric tumor tissues compared with normal tissues (Mean = 2.087, p= 0.0484). The relative expression of the NFKB gene revealed no statistically significant difference between the gastric tumor tissues compared with normal tissues (P=0.3728). In addition, clinicopathologic data compared with NKILA and NFKBmRNA expression levels in gastric cancer tissues showed no significant association. Here, we found no significant association between the level of NKILA expression compared with NFKB mRNA level in gastric cancer tissues (R=0.03; P=0.2355).
Conclusion: Our results showed that NKILA had a significant association with GC. Our findings also revealed that NKILA expression was not correlated with NFKB mRNA level in GC tissues.
Status and correlates of attitudes towards end-of-life care among nursing students
Authors: Younis Wejdan Othman , Alduraidi Hamza , Zeilani Ruqayya Sayyed. , Hamdan-Mansoor Ayman Mohammad 
Published: March 2022

Background & Aim: Palliative nursing is based on the ability of nursing students to use their accumulated experiences and knowledge; however, basic nursing education does not provide adequate knowledge and skills regarding palliative and end-of-life care. This study aimed to examine the relationship between knowledge of end-of-life care and attitudes toward dying people among nursing students.
Methods & Materials: Cross-sectional, descriptive-correlational design was used in this study. A total of 708 nursing students were recruited conveniently from nursing students in 11 nursing programs. Data was collected using an online self-administered questionnaire in relation to knowledge and attitudes regarding palliative care using the palliative care quiz for nursing and Frommelt Attitudes Toward Care of the Dying Scale Form B (FATCOD-B).
Results: Nursing students have a satisfactory level of knowledge about palliative care with a mean of 61.0% and 50% of them scoring 83% correct answers. Moreover, students also have a moderate to high mean score (102.7, SD= 11.2) on attitudes towards caring for dying patients, indicating positive attitudes. Positive correlation found between communication and family as caregiver subscales of attitudes with knowledge total score (r= .08, r= .20, p< .05; respectively). The significant difference was found in attitudes related to gender, type of university, and whether receiving training or education about palliative care at school (p< .05).
Conclusion: Attitudes of nursing students and improving the level of knowledge regarding end of life care should be a priority to nurse educators, and nursing schools need to integrate palliative and end-of-life care into nursing curricula across all levels.
ECONOMIC WEED THRESHOLD OF MARANTA SOBOLIFERA PLANTS IN OFF-SEASON CORN
Authors: KUHN VITOR GUSTAVO , FERREIRA SILVIO DOUGLAS , DE CARVALHO ALYSSON OLIVEIRA , FEY EMERSON , DA COSTA NEUMÁRCIO VILANOVA 
Published: March 2022

Maranta sobolifera (Caetê) has tolerance to chemical management and has spread consistently on the agricultural areas of the western region of Paraná over the years. However, there is little information about its potential to interfere with the main agricultural crops. This study aimed to estimate the economic weed threshold (EWT) of M. sobolifera plants in commercial areas of production of off-season corn. There were losses in grain yield of up to 303.7 kg plant-1 of M. sobolifera. Considering an acceptable loss in grain yield of 614.05 kg ha-1, EWT estimates varied from 2.0 to 41.2 plants m-2 of M. sobolifera. In practice, these data can be used in no-till areas, where complementary control is necessary at the crop post-emergence (V4-V6), after desiccation of the area, to maintain weed density at tolerable levels until the end of the cycle. In addition, factors such as the use of less competitive hybrids, obtaining the maximum productive potential of the crop, increasing the value of the harvested product and the efficiency of chemical management (desiccation) and a reduction in the cost of control contribute to the reduction of the EWT and make the adoption of management practices of M. sobolifera more profitable in off-season corn.
Historia antropologii w Polsce
Authors: Bielicki Tadeusz , Krupiński Tadeusz , Strzałko Jan 
Published: March 2022

Artykuł niniejszy ukazał się w 1985 roku w Anglii jako szósta z kolei pozycja w serii małych monografii, wydawanych przez Międzynarodowe Stowarzyszenie Biologów Człowieka i poświęconych dziejom antropologii fizycznej w różnych krajach (International Association of Humań Biologists, Occasional Papers, ed. D. F. Roberts, Newcastle upon Tyne, England).
Ponieważ opracowanie to dotarło do Polski tylko w kilkunastu egzemplarzach rozesłanych polskim członkom stowarzyszenia, redakcja "Przeglądu" zdecydowała się na opublikowanie jego wersji polskiej, w mniemaniu, że może ona być przydatna, np. dla celów dydaktycznych. Artykuł napisany został pierwotnie w języku angielskim (przez jednego z trójki autorów, na podstawie szczegółowego konspektu opracowanego wspólnie przez wszystkich trzech). Tekst tu publikowany jest wiernym przekładem z oryginału angielskiego. Należy pamiętać, że pisany on był z myślą o czytelniku niepolskim; stąd np. w doborze piśmiennictwa autorzy dawali, gdzie to było możliwe, priorytet publikacjom w językach angielskim, niemieckim lub francuskim. Przekładu oryginału na język polski dokonała Zofia Prele, co odnotowujmy z podziękowaniem.
Perbandingan Minyak Atsiri Bunga Kenanga (Cananga odorat) Segar dan Kenanga Layu
Authors: Amelia Danna , Rubiyanto Dwiarso 
Published: March 2022

Isolasi dan identifikasi sifat fisika-kimia minyak atsiri bunga kenanga (Cananga odorata) segar dan layu telah dilakukan dalam penelitian ini. Minyak atsiri bunga kenanga diisolasi dengan metode destilasi uap. Komponen kimia dari dua kondisi bahan bunga kenanga dianalisis menggunakan instrumen GCMS. Beberapa parameter fisika meliputi uji warna, bau, berat jenis dan indeks bias dilakukan dalam penelitian ini. Hasil analisis diketahui rendemen minyak atsiri pada bunga kenanga segar dan layu masing-masing adalah 0,325%(b/b) dan 0,276%(b/b). Komponen senyawa kimia utama yaitu 1-metoksi-4-metil benzena (3,05%) linalool (22,06%), geranil asetat (7,54%), trans-kariofilen (28,06%),a-humulen (8,65%) dan D-germacren (21,91%), sedangkan penyusun minyak kenanga layu adalah 1-metoksi-4-metil benzena (2,79%), linalool (21,76%), trans-kariofilen (31,87%), a-humulen (9,25%) dan D-germacren (21,62%). Hasil uji sifat fisika-kimia minyak bunga kenanga segar berwarna kuning bening, bau harum kenanga, berat jenis 0,9157 dan indeks bias 1,5039, sedangkan untuk minyak bunga kenanga layu berwarna bening jernih, bau harum sangit, berat jenis 0,9138 dan indeks bias 1,5040.
Adsorpsi Pb(II) dari Air dengan Karbon Aktif dari Kulit Salak Pondoh: Kinetika dan Isoterm Adsorbsi
Authors: Anugrahwati Mai , Indah Fajarwati Febi , Awalin Safitri Rika 
Published: March 2022

Dalam penelitian ini kulit salak pondoh disintesis menjadi karbon aktif sebagai adsorben ion Pb2+. Proses perubahan ini melibatkan metode karbonisasi dan aktivasi yang terjangkau menggunakan KOH. Material adsorben yang diperoleh selanjutnya dikarakterisasi dengan FTIR dan digunakan pada kajian kinetika dan isotherm adsorbsi pada larutan yang mengandung Pb2+. Hasil karakterisasi menunjukkan gugus fungsi yang mungkin terlibat dalam adsorpsi seperti O-H. Pada aplikasi adsorpsi, penentuan konsentrasi Pb2+ dianalisis menggunakan Spektrofotometri Serapan Atom (SSA). Kondisi waktu optimum adsorpsi dalam penelitian ini adalah 15 menit dengan kapasitas adsorpsi mencapai 90% dimana kinetika adsorbsi mengikuti pseudo orde dua sedangkan isotherm adsorpsinya sesuai dengan persamaan isoterm Langmuir.
Ekstrak Etanolik Seledri (Apium graveolens L.) Memperbaiki Indeks Aktivitas Penyakit Kolitis Ulseratif dan Makroskopik Panjang Kolon Pada Tikus Yang di Induksi Asam Asetat
Authors: Dewangga Ardian , Saputra Chandra , Sahid Muhammad Novrizal Abdi , Gani Andayana Puspitasari 
Published: March 2022

Kolitis ulseratif adalah kondisi peradangan yang menyerang kolon, dipengaruhi faktor genetik, gangguan imun, dan lingkungan yang ditandai adanya peradangan pada kolon dan bisa berlanjut pada pembentukan luka atau ulkus serta juga dapat memicu tumbuhnya kanker. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etanolik seledri untuk perbaikan indeks aktivitas penyakit kolitis ulseratif pada tikus yang diinduksi asam asetat. Lima belas ekor tikus wistar jantan secara acak dibagi menjadi lima kelompok yaitu kelompok normal, kontrol positif (pemberian 5-asam amino salisilat), kontrol negatif, dan ekstrak etanolik seledri (dosis 100 mg/KgBB dan 300 mg/KgBB). Asam asetat 4 % sebagai penginduksi kolitis diberikan pada semua kelompok kecuali kelompok normal. Respon inflamasi terhadap induksi kolitis dinilai dengan mengamati indeks aktivitas penyakit kolitis ulseratif dan makroskopik panjang kolon. Hasil penelitian menunjukan terjadi penurunan indeks aktivitas penyakit kolitis ulseratif dan makroskopik panjang kolon setelah mendapat ekstrak etanolik seledri pada dosis 100 mg/KgBB dan 300 mg/KgBB pada tikus yang diinduksi asam asetat 4%. Dosis 300 mg/kgBB menunjukkan aktivitas yang lebih baik dari dosis 100 mg/kgBB dari parameter indeks aktivitas penyakit dan makroskopik panjang kolon. Pada pengukuran panjang kolon dosis 300 mg/kgBB menunjukkan perbedaan siginifkan dibandingkan kontrol negatif (p&lt;0,05). Dari parameter kolitis diatas menunjukkan bahwa EES mempunyai potensi yang baik dalam terapi kolitis ulseratif. <p> </p>