bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variantes genéticas relacionadas a leptina e seu impacto sobre a obesogênese
Authors: Costa Jardel Alves da , Carneiro Cláudia Resende , Silva Lilian Carvalho da , Fontinele Renata Rodrigues Costa , Mendes Taynara de Sousa Rego , Barros Gabrielly Martins de , Rodrigues Natanael Alison Carvalho , Damasceno Dênaba Luyla Lago , Freire Layanna Moreira , Lima Diêgo de Oliveira , Macedo Kelly Vanderlei , Torres Renata Rios , Sousa Francisca Maria de , Cunha Erico Fabrício Nunes da 
Published: March 2022

Este trabalho objetiva realizar revisão da literatura, afim de reunir estudos que evidenciem a relação entre a presença de polimorfismos genéticos associados a leptina e o desenvolvimento da obesidade. Trata-se de uma revisão integrativa da literatura, elaborada a partir das seguintes etapas: elaboração da pergunta norteadora, busca ou amostragem na literatura, coleta de dados, análise crítica dos estudos incluídos, discussão dos resultados e apresentação da revisão integrativa. A pergunta norteadora construída foi: Variantes genéticas associadas a leptina podem exercer efeitos sobre o desenvolvimento da obesidade? Inicialmente, a estratégia para a busca dos estudos foi composta pela combinação de descritores controlados (leptina, distúrbios, metabolismo, polimorfismos e obesidade) indexados nos Descritores em Ciências da Saúde (DeCS/MeSH). Na primeira triagem, baseada nos critérios de inclusão e exclusão, eliminaram-se 14073 estudos. Após a elegibilidade/avaliação crítica dos textos completos de 360 registros, 5 atenderam aos critérios de inclusão e prosseguiram para fase de extração de dados, leitura exaustiva e síntese do conhecimento. Os resultados apresentados e discutidos apontam relação entre a presença de variantes genéticas e alterações no processo de síntese de leptina, assim como modificações no processo de ligação do hormônio aos seus receptores impactando em processos metabólicos que favorecem a obesogênese.
Efeito do posicionamento do dreno pleural na função pulmonar, capacidade pulmonar e força muscular respiratória no pós-operatório de revascularização do miocárdio: revisão sistemática
Authors: Caetano Débora Sidrônio , Moura Pedro Henrique de , Barros Ana Eugênia Vasconcelos do Rêgo , Araújo Claudia Regina da Silva , Aguiar Maria Inês Remígio de , Andrade Arméle de Fátima Dornelas de , Campos Shirley Lima , Brandão Daniella Cunha 
Published: March 2022

Objetivo: verificar o efeito do posicionamento do dreno pleural sobre a função pulmonar, força muscular respiratória e capacidade funcional de pacientes no pós-operatório imediato de revascularização do miocárdio. Metodologia: Revisão sistemática com busca de artigos nas bases de dados MEDLINE (via PubMed), Cochrane Central, LILACS, Scielo, CINAHL e Scopus, não havendo restrição quanto a data de publicação ou idioma. A qualidade metodológica dos estudos foi avaliada com base na Cochrane Risk of Bias Tool. Resultados: A estratégia de busca resultou em 95 títulos, dos quais sete foram incluídos nesta revisão, totalizando 313 participantes, incluindo ambos os sexos e idades entre 35 e 80 anos. Os desfechos encontrados nos estudos foram função pulmonar, força muscular respiratória, capacidade funcional, dor e complicações pulmonares. Conclusão: O dreno pleural subxifóide parece provocar uma menor redução na função pulmonar, enquanto os efeitos sobre a força muscular respiratória e complicações pulmonares ainda são conflitantes.
A importância da gestão democrática participativa na execução do programa dinheiro direto na escola (PDDE)
Authors: Araújo Kathy Souza Xavier de , Guerra Maria das Graças Gonçalves Vieira , Nascimento Giselle Oliveira do 
Published: March 2022

O objetivo deste artigo é verificar a importância da gestão democrática participativa na identificação dos fatores determinantes nos processos de gestão do PDDE, a partir de uma revisão da literatura dos artigos publicados no período de 2000 a 2020. Utilizou-se uma metodologia de caráter exploratório, com abordagem qualitativa e estratégia bibliográfico-documental. Foram identificados 48 artigos publicados no período analisado. A análise dos artigos possibilitou identificar quatro fatores determinantes: Capacitação, Gestão Participativa, Controle Social e Gestão dos Recursos e Autonomia. Os resultados da análise são fundamentais na delimitação de políticas de monitoramento visando mitigar as dificuldades dos processos de gestão do PDDE. A gestão democrática e participativa é complexa, sobretudo em um programa de abrangência nacional, que envolve diferentes atores sociais, cuja atuação sobre a influência de vários fatores institucionais, econômicos, políticos, sociais e culturais. Os resultados do estudo podem auxiliar na realização de futuros estudos sobre cada um dos fatores determinantes identificados.
Evidências sobre tipos de intervenções para a institucionalização da assistência farmacêutica: revisão integrativa
Authors: Silva Kleber Farias da , Torres Andréa Sarmento Figueiredo , Soler Orenzio 
Published: March 2022

Introdução: A assistência farmacêutica trata de um conjunto de ações voltadas à promoção, proteção e recuperação da saúde, tanto individual como coletivo, tendo o medicamento como insumo essencial e visando o acesso e ao seu uso racional. Objetivo: Sintetizar evidências sobre estratégias de intervenções no contexto da institucionalização da assistência farmacêutica no Brasil. Metodologia: Revisão integrativa. Resultados: Foram recuperados 16.356 registros: 11 do Health Evidence, 43 do Epistemonikos, 01 da Cochrane, 20 da Health Systems Evidence, 4.369 da Biblioteca Virtual em Saúde e 11.700 do Google Scholar. 19 artigos foram selecionados: 15 estudos transversais, 02 revisões da literatura e 02 estudos de caso. Conclusão: Intervenções educacionais, organizacionais, políticas setoriais, financeiras e regulatórias são reconhecidas melhorar desfechos clínicos, humanísticos e econômicos no campo da institucionalização da assistência farmacêutica.
Pelatihan Dan Bimbingan Teknis Pembuatan Peta Tanah Di Sekolah Menengah Atas Di Kota Kendari
Authors: Mey Djafar , Karim Jufri , Rustam La Ode , Fitriani Fitriani 
Published: March 2022

Knowledge about the land and the skills in making land maps provided is one of the efforts made to create appropriate resources. Efforts to increase knowledge and skills that can be done are introduction of soil descriptions and profiles along with training in making land maps. The purpose of this training and technical guidance activity is to provide students with an understanding of the soil at the high school level, knowing about soil resources in detail to students, knowing the procedures for making a land map using Geographic Information Systems (GIS) and knowing how to conduct soil investigations in the field. The problem solving framework of this activity is carried out in several stages, namely preparation, preparation of training materials, presentation of material by resource persons, discussions and questions and answers, practice of making land maps, and practice of making soil profiles by dividing student groups, evaluating the results of activities and preparing reports. This training was held in SMA Neg. 4 Kendari and SMA Neg. 6 Kendari. The result of this training and technical guidance is that the trainees have added knowledge and skills in making land descriptions and profiles, as well as making land maps using the geogarfi information system application. Keywords:. Training Students, Land, Geographic Information Systems
Pemberdayaan Masyarakat Tani Dalam Meningkatkan Pendapatan Rumah Tangga Desa Mekar Jaya Kecamatan Dangia Kabupaten Kolaka Timur
Authors: Nurwati Nurwati , Husin Husin 
Published: March 2022

Pelatihan ini berjudul Pemberdayaan Masyarakat Tani Dalam Meningkatkan Pendapatan Rumah Tangga Desa Mekar Jaya Kecamatan Dangia Kabupaten Kolaka Timur Sulawesi Tenggara. Tujuan pelatihan ini adalah memberikan pemahaman kepada masyarakat Desa Mekar Jaya Kecamatan Dangia Kabupaten Kolaka Timur agar memahami pentingnya pemberdayaan masyarakat tani dalam meningkatkan pendapatan rumah tangga menuju kemandirian ekonomi dan peningkatan pendapatan bagi masyarakat tani. Metode yang digunakan dalam pelatihan adalah metode ceramah (pengarahan) dan penjelasan secara serempak terhadap masyarakat. Metode diskusi serta tanya jawab juga dilakukan setelah selesai diberikan ceramah (pengrahan/penjelasan) mengenai pentingnya pemberdayaan masyarakat tani dalam meningkatkan pendapatan rumah tangga menuju kemandirian ekonomi dan peningkatan pendapatan bagi masyarakat tani desa mekar jaya kecamatan dangia kabupaten kolaka timur, Sulawesi Tenggara. Dari evaluasi dan hasil yang telah dilakukan pada aktivitas pelatihan terhadap 15 orang kepada karyawan dan masyarakat maka ditemukan peningkatan pemahaman akan pentingnya “Pemberdayaan Masyarakat Tani Dalam Meningkatkan Pendapatan Rumah Tangga Menuju Kemandirian Ekonomi dan Peningkatan Pendapatan Bagi Masyarakat Tani Desa Mekar Jaya Kecamatan Dangia Kabupaten Kolaka Timur, Sulawesi Tenggara” dengan tingkat keberhasilan sebesar 85%.
PELATIHAN LOGICAL BLOCK CODING UNTUK INTERVENSI KEGIATAN ANAK-ANAK SELAMA SOCIAL DISTANCING COVID19 BAGI SISWA JENJANG SD-SMP DI PROVINSI SULAWESI TENGGARA
Authors: Muhtar Norma Muhtar , Cahyono Edi , Ruslan Ruslan , Tenriawaru Andi , Laome Lilis 
Published: March 2022

Untuk memutus rantai pandemi Covid-19, pemerintah telah mengambil kebijakan pembatasan sosial seperti menjaga jarak sosial (social distancing) menghindari kontak fisik (physical distancing), dan tetap tinggal di rumah (stay at home). Dampak di bidang pendidikan, kegiatan pembelajaran seluruhnya dilakukan dari rumah secara online, yang memaksa anak-anak menggunakan gadget. Orang tua yang mulai resah karena anak-anak memakai gadget sepanjang hari. Ada kekawatiran anak-anak menggunakan gadget untuk bermain game setelah waktu belajar. Di sisi lain, anak-anak muncul rasa jenuh, stres, cemas, dan frustasi karena harus berdiam di rumah ditemani gadget untuk belajar dan bermain tanpa ada tantangan yang bisa dihasilkan dari bermain gadget.Coding mentransformasi perilaku anak dari pemain game menjadi pembuat game dan membiasakan anak berpikir problem solving. Salah satu jenis coding yang sesuai untuk anak-anak yaitu Logical Block Coding yang menggunakan balok-balok kode dengan bentuk dan warna yang berbeda-beda agar pengguna dapat membedakan fungsi dari masing-masing balok agar tercipta sebuah fungsi atau program.Pelatihan logical block coding merupakan kegiatan KKN-Tematik untuk menjawab keresahan orang tua dan kebosanan anak dengan cara mengintervensi kegiatan anak melalui aktifitas produktif, merangsang logika anak, dan membuat anak senang serta selalu terbangkitkan mood setiap harinya, sehingga siswa-siswa SD dan SMP di Sulawesi Tenggara selalu gembira dan terjaga imun tubuh selama masa pandemi covid19.Pelatihan dilaksanakan selama empat minggu oleh 24 mahasiswa di tempat domisili masing-masing mahasiswa pada 17 kabupaten/kota. Setiap mahasiswa wajib melatih satu orang siswa SD dan satu orang siswa SMP secara tatap muka dan dimonitoring secara berkala oleh dosen pembimbing secara online. Materi pelatihan merujuk pada panduan tutorial teks dan media video dari dosen pembimbing.Luaran kegiatan diperoleh 48 game komputer sederhana, respon positif dari seluruh orangtua yang mendukung adanya pelatihan coding, dan ekspresi siswa yang senang karena bisa membuat game. Sebagian besar siswa merespon untuk belajar lebih lanjut tentang coding.
Penerapan Edukasi Saintek di Desa Transmigrasi Lalowiu Kecamatan Konda Kabupaten Konawe Selatan Untuk Membangun Masyarakat Yang Sehat dan Mandiri
Authors: Cahyono Edi , Arman Arman , Sudayasa Putu , Budiman Herdi , Ransi Natalis 
Published: March 2022

Sebagai suatu desa transmigrasi, Desa Lalowiu terletak diperbatasan antara Kota Kendari dengan Kabupaten Konawe Selatan Propinsi Sulawesi Tenggara. Kondisi lingkungan desa ini pada umumnya belum terlalu sehat yang dapat menimbulkan beberapa penyakit tropis termasuk COVID-19 ini. Untuk meningkatkan mutu kehidupan transmigran, pemerintah telah menempuh berbagai upaya antara lain peningkatan pendidikan dan pembinaan kesehatan. Selain itu juga melakukan pembinaan usaha ekonomi yang meliputi pembinaan usaha ekonomi berupa pembinaan usaha produksi, pengolahan hasil pertanian serta pembinaan pemasaran dan kelembagaan ekonomi desa. Berdasrkan potensi dan permasalahan tersebut mendorong Universitas Halu Oleo untuk melakukan kegiatan pengabdian kepada masyarakat yang terintegrasi KKN-Tematik di daerah tersebut. Tujuan umum dari kegiatan pengabdian terintegrasi KKN Tematik ini adalah menciptakan masyarakat yang mandiri, sehat dan cerdas. Namun secara khusus kegiatan pengabdian ini bertujuan: 1) Memberikan wawasan kepada masyarakat akan pentingnya kesehatan keluarga untuk penanggulangan COVID-19 dan penyakit lainnya, 2) Memberikan pengetahuan pola hidup bersih dan sehat di lingkungan keluarga dan sekolah, 3) Memberikan beberapa penerapan sains dan teknologi di daerah pedesaan. 4) Meningkatnya ketahanan pangan keluarga dengan memanfaatkan lahan pekarangan dengan menanam sayuran dan pemeliharaan unggas dan ikan menggunakan teknik pembudidayaan yang praktis.
PENINGKATAN KAPASITAS MASYARAKAT DALAM TEKNIK PANEN & PENANGANAN PASCAPANEN PROPOLIS LEBAH TANPA SENGAT DI DESA ABENGGI KONSEL
Authors: Pujirahayu Niken , Marwah Sitti , Rosmarlinasiah Rosmarlinasiah , Kasim Safril , Tuheteru Faisal Danu , Mando La Ode Agus Salim , Kabe Abigael , Rahmatiah T Eka 
Published: March 2022

Abenggi Village, Landono District, Southeast Sulawesi is an agricultural area bordering a forest area with great potential for developing honey bee cultivation. Several farmer groups have cultivated stingless bees, such as Trigona sp. However, this effort is still not optimal because the only product that has been used and can be sold is honey, while other products such as bee bread and propolis are still wasted and unused. The purpose of this activity is raise awareness of farmer group members about the importance of proper harvesting and processing techniques for each bee product and improve community skills in harvesting and processing bee products, especially processing propolis into propolis blocks as a source of health and increasing their income. The method used is a participatory method with the formation of target groups, lectures/discussions, and technical guidance on harvesting and making propolis blocks. Monitoring and evaluating the success of activities using pre-test and post-test methods. The results of the activity: (1) 100% bee farmer group participation, (2) knowledge and skills of group members in harvesting techniques and post-harvest processing of propolis into propolis blocks increased (3) people became aware of propolis processing techniques that are more hygienic, can be stored and sold.
A Novel Solution for Distal Dilation of Chronic Dissection After Repair Involving Visceral Branches: The Road Block Strategy
Authors: Li Yiming , Li Zhenjiang , Feng Jiaxuan , Feng Rui , Zhou Jian , Jing Zaiping 
Published: March 2022

AimNotwithstanding that unprecedented endovascular progress has been achieved in recent years, it remains unclear what is the best strategy to preserve the blood perfusion of abdominal visceral arteries and promote positive aortic remodeling in patients with distal dilatation of chronic aortic dissection in abdominal visceral part (CADAV) after aortic repair. The present study developed a Road Block Strategy (RBS) to solve this conundrum.Methods and ResultsThis prospective single-center clinical study included patients suffering from symptomatic distal dilatation of CADAV after aortic repair treated with RBS from January 2015 to December 2019 and followed up regularly for at least 2 years. Stent grafts were implanted first to cover distal tears and expand the true lumen. Device embolization was performed to induce proximal and distal segmental false lumen thrombosis (FLT) apart from the level of the ostia of vital branches. Successful RBS was performed in 13 patients. Significant differences were found in maximum true lumen diameter (p &lt; 0.05), blood flow area in false lumen (FL) (p &lt; 0.001), and the ratio of blood lumen to FL area (p &lt; 0.05) between the pre-procedure and the latest follow-up results. No aortic rupture, vital branches occlusion, thoracic and abdominal pain, or death occurred during hospitalization and follow-up.ConclusionsOur findings suggest that RBS is feasible in treating distal dilatation of chronic aortic dissection after prior proximal repair, inducing false lumen thrombosis, preventing deterioration of aortic dissection, and maintaining the patency of abdominal visceral arteries.
Heavy and Light Mineral Association of Late Quaternary Permafrost Deposits in Northeastern Siberia
Authors: Schirrmeister L. , Wetterich S. , Schwamborn G. , Matthes H. , Grosse G. , Klimova I. , Kunitsky V. V. , Siegert C. 
Published: March 2022

We studied heavy and light mineral associations from two grain-size fractions (63–125 μm, 125–250 µm) from 18 permafrost sites in the northern Siberian Arctic in order to differentiate local versus regional source areas of permafrost aggradation on the late Quaternary time scale. The stratigraphic context of the studied profiles spans about 200 ka covering the Marine Isotope Stage (MIS) 7 to MIS 1. Heavy and light mineral grains are mostly angular, subangular or slightly rounded in the studied permafrost sediments. Only grains from sediments with significantly longer transport distances show higher degrees of rounding. Differences in the varying heavy and light mineral associations represent varying sediment sources, frost weathering processes, transport mechanisms, and post-sedimentary soil formation processes of the deposits of distinct cryostratigraphic units. We summarized the results of 1141 microscopic mineral analyses of 486 samples in mean values for the respective cryostratigraphic units. We compared the mineral associations of all 18 sites along the Laptev Sea coast, in the Lena Delta, and on the New Siberian Archipelago to each other and used analysis of variance and cluster analysis to characterize the differences and similarities among mineral associations. The mineral associations of distinct cryostratigraphic units within several studied profiles differ significantly, while others do not. Significant differences between sites as well as between single cryostratigraphic units at an individual site exist in mineral associations, heavy mineral contents, and mineral coefficients. Thus, each study site shows individual, location-specific mineral association. The mineral records originate from multiple locations covering a large spatial range and show that ratios of heavy and light mineral loads remained rather stable over time, including glacial and interglacial periods. This suggests mostly local sediment sources and highlights the importance of sediment reworking under periglacial regimes through time, including for example the formation of MIS 1 thermokarst and thermo-erosional deposits based on remobilized MIS 3 and 2 Yedoma Ice Complex deposits. Based on the diverse mineralogical results our study supports the viewpoint that Yedoma Ice Complex deposits are mainly results of local and polygenetic formations (including local aeolian relocation) superimposed by cryogenic weathering and varying climate conditions rather than exclusive long distance aeolian transport of loess, which would have highly homogenized the deposits across large regions.
Case Report: New CDKN1B Mutation in Multiple Endocrine Neoplasia Type 4 and Brief Literature Review on Clinical Management
Authors: Lavezzi Elisabetta , Brunetti Alessandro , Smiroldo Valeria , Nappo Gennaro , Pedicini Vittorio , Vitali Eleonora , Trivellin Giampaolo , Mazziotti Gherardo , Lania Andrea 
Published: March 2022

BackgroundThe fourth type of multiple endocrine neoplasia (MEN) is known as a rare variant of MEN presenting a MEN1-like phenotype and originating from a germline mutation in CDKN1B. However, due to the small number of cases documented in the literature, the peculiar clinical features of MEN4 are still largely unknown, and clear indications about the clinical management of these patients are currently lacking. In order to widen our knowledge on MEN4 and to better typify the clinical features of this syndrome, we present two more cases of subjects with MEN4, and through a review of the current literature, we provide some possible indications on these patients’ management.Case PresentationThe first report is about a man who was diagnosed with a metastatic ileal G2-NET at the age of 34. Genetic analysis revealed the mutation p.I119T (c.356T&gt;C) of exon 1 of CDKN1B, a mutation already reported in the literature in association with early-onset pituitary adenomas. The second report is about a 76-year-old woman with a multifocal pancreatic G1-NET. Genetic analysis identified the CDKN1B mutation c.482C&gt;G (p.S161C), described here for the first time in association with MEN4 and currently classified as a variant of uncertain significance. Both patients underwent biochemical and imaging screening for MEN1-related diseases without any pathological findings.ConclusionsAccording to the cases reported in the literature, hyperparathyroidism is the most common clinical feature of MEN4, followed by pituitary adenoma and neuroendocrine tumors. However, MEN4 appears to be a variant of MEN with milder clinical features and later onset. Therefore, these patients might need a different and personalized approach in clinical management and a peculiar screening and follow-up strategy.
Clinical Characteristics and Pathogenic Gene Identification in Chinese Patients With Paget’s Disease of Bone
Authors: Tao Xiaohui , Liu Li , Yang Xingguang , Wei Zhe , Chen Zhongzhong , Zhang Ge , Zhang Zhenlin , Yue Hua 
Published: March 2022

ObjectiveTo evaluate the clinical features of sporadic Paget’s disease of bone (PDB) in China and further explore the underlying genetic abnormalities of the disease.MethodsClinical characteristics, biochemical indices, bone turnover markers and radiographic examinations of the patients were collected. Genomic DNA was extracted from peripheral blood and whole-exome sequencing was carried out to identify the potential pathogenic genes. The pathogenicity of the variants was thereafter investigated by bioinformatics analysis.ResultsA total of 50 patients (57.20 ± 15.52 years, male/female: 1.63: 1) with PDB were included and the mean onset age was 48.34 years (48.34 ± 17.24 years). 94.0% of the patients exhibited symptomatic patterns described as bone pain (86.0%), elevated skin temperature at the lesion site (26.0%), bone deformity (22.0%) and local swelling (18.0%). The most frequently involved lesion sites were pelvis (52.0%), femur (42.0%), tibia (28.0%), skull (28.0%) and spine (18.0%), respectively. Additionally, 40.0% of them accompanied with osteoarthritis, 14.0% with pathological fractures, and the misdiagnosis rate of PDB was as high as 36.0%. Serum level of alkaline phosphatase was significantly increased, with the mean value of 284.00 U/L (quartiles, 177.00-595.00 U/L). Two heterozygous missense mutations of SQSTM1 gene (c.1211T&gt;C, M404T) and one novel heterozygous missense mutation in HNRNPA2B1 gene (c.989C&gt;T, p. P330L) were identified in our study. Moreover, several potential disease-causing genes were detected and markedly enriched in the pathways of neurodegeneration (including WNT16, RYR3 and RYR1 genes) and amyotrophic lateral sclerosis (ALS, including NUP205, CAPN2, and NUP214 genes).ConclusionIn contrast to Western patients, Chinese patients have an earlier onset age, more severe symptoms, and lower frequency of SQSTM1 gene mutation (4.0%). Moreover, a novel heterozygous missense mutation in HNRNPA2B1 gene was identified in one male patient with isolated bone phenotype. As for other genetic factors, it was indicated that WNT16, RYR3, RYR1, NUP205, CAPN2 and NUP214 genes may be potential pathogenic genes, pathways of neurodegeneration and ALS may play a vital role in the pathogenesis of PDB.