bluuebunny/crossref_metadata_2025_split huggingface dataset:
Participation in welfare legislation—A poverty‐aware paradigm
Authors: Cohen‐Rimer Yael 
Published: January 2022

AbstractPublic participation, responsive regulation, and other policy formulations are intended to draw governments down from their ivory towers and into engagement with the people. However, they paint at best, a hazy picture of who “the people” are. This superficial representation is felt, among other collectives, by people living in poverty, who not only face hunger, often accompanied by poorer health and lower life expectancy, but whose social exclusion typically goes unrecognized by the authorities. The legal framing of poverty—and, as a result, states' policy approaches to its alleviation—focuses on the material core, representing a very thin conceptualization that fails to address the social dimension. Furthermore, practical avenues for incorporating citizens' views into lawmaking—which might enrich understanding—are lacking when it comes to people in poverty. Combined with a blatantly hegemonic stance, the resulting ignorance around poverty and “the poor” generates welfare laws that are woefully out of touch with reality, and legislative thinking that perpetuates, rather than alleviates, poverty. This paper seeks to make a twofold contribution: (i) to demonstrate this situation with a deep empirical inquiry into the legislative process of one legal provision within the Israeli welfare law regime, juxtaposed against qualitative field‐research findings and (ii) to introduce the inventive and groundbreaking “poverty‐aware” paradigm, constructed in social‐work discourse, to illuminate and explain the empirical findings and point to potential procedural–institutional reform, to pave the way for poverty‐aware legislation.
Collective learning and COVID‐19 mitigation in Ghana
Authors: Osei‐Kojo Alex , Kenney Paul Lawer , Damoah Clement Mensah , Ahenkan Albert 
Published: January 2022

AbstractCOVID‐19 has created significant uncertainty and disruption among governments and people across the globe. Policy studies present various theoretical frameworks that allow scholars and practitioners to make sense of these developments in a structured and systematic fashion. In this paper, we combined the collective learning framework with documentary data and process tracing analysis to describe, first, the features of the COVID‐19 collective learning setting in Ghana. Next, we explored the linkages among learning processes, learning products, and COVID‐19 mitigation. We found that diverse policy actors operated at distinct levels of government and performed different functions in managing the pandemic. Furthermore, we confirmed all three phases of learning (acquisition, translation, and dissemination) in Ghana's context. Lastly, policies, such as public gathering management, mandatory mask‐wearing, partial lockdown, and fiscal and tax reliefs enabled the government to mitigate the pandemic's impact on people. We conclude by highlighting the implications of these findings for policy learning scholarship.
The Barker Proposal: Combining Robustness and Efficiency in Gradient-Based MCMC
Authors: Livingstone Samuel , Zanella Giacomo 
Published: January 2022

AbstractThere is a tension between robustness and efficiency when designing Markov chain Monte Carlo (MCMC) sampling algorithms. Here we focus on robustness with respect to tuning parameters, showing that more sophisticated algorithms tend to be more sensitive to the choice of step-size parameter and less robust to heterogeneity of the distribution of interest. We characterise this phenomenon by studying the behaviour of spectral gaps as an increasingly poor step-size is chosen for the algorithm. Motivated by these considerations, we propose a novel and simple gradient-based MCMC algorithm, inspired by the classical Barker accept-reject rule, with improved robustness properties. Extensive theoretical results, dealing with robustness to tuning, geometric ergodicity and scaling with dimension, suggest that the novel scheme combines the robustness of simple schemes with the efficiency of gradient-based ones. We show numerically that this type of robustness is particularly beneficial in the context of adaptive MCMC, giving examples where our proposed scheme significantly outperforms state-of-the-art alternatives.
The Bayesian Spatial Bradley–Terry Model: Urban Deprivation Modelling in Tanzania
Authors: Seymour Rowland G. , Sirl David , Preston Simon P. , Dryden Ian L. , Ellis Madeleine J. A. , Perrat Bertrand , Goulding James 
Published: January 2022

Abstract
Identifying the most deprived regions of any country or city is key if policy makers are to design successful interventions. However, locating areas with the greatest need is often surprisingly challenging in developing countries. Due to the logistical challenges of traditional household surveying, official statistics can be slow to be updated; estimates that exist can be coarse, a consequence of prohibitive costs and poor infrastructures; and mass urbanization can render manually surveyed figures rapidly out-of-date. Comparative judgement models, such as the Bradley–Terry model, offer a promising solution. Leveraging local knowledge, elicited via comparisons of different areas’ affluence, such models can both simplify logistics and circumvent biases inherent to household surveys. Yet widespread adoption remains limited, due to the large amount of data existing approaches still require. We address this via development of a novel Bayesian Spatial Bradley–Terry model, which substantially decreases the number of comparisons required for effective inference. This model integrates a network representation of the city or country, along with assumptions of spatial smoothness that allow deprivation in one area to be informed by neighbouring areas. We demonstrate the practical effectiveness of this method, through a novel comparative judgement data set collected in Dar es Salaam, Tanzania.
The Psychology of White Nationalism: Ambivalence Towards a Changing America
Authors: Reyna Christine , Bellovary Andrea , Harris Kara 
Published: January 2022

AbstractThe rise in White nationalist ideology in America is one of the pressing issues of our times. In this article, we make the case that White nationalists both extol the talents and virtues of White Americans and idolize and romanticize a former White‐dominated America, while simultaneously condemning and demonizing the current state of America for Whites. This fundamentally ambivalent ideology contributes to dangerous downstream consequences such as fomenting violence against groups that threaten Whites’ status and resources and even calling for outright civil war. This article also examines the psychological impact of rapid demographic and cultural changes on groups in positions of power, and how these changes make some Whites, especially those who might already be suffering from instability, disenfranchisement, and loss, gravitate to groups who validate their fears and transform them into aggrieved entitlement and moral outrage. Finally, this article proposes policies that decision‐makers and other leaders can take to undo the foundational ideologies that White supremacy is built upon and to help curtail its spread.
Development of Three-Stage Bioaerosol Sampler for Size-Selective Sampling
Authors: Lim Jun-Hyung , Nam Sang Hwan , Kim Jongwoo , Kim Nam Hoon , Park Gun-Soo , Maeng Jin-Soo , Yook Se-Jin 
Published: January 2022

Abstract
In this study, a three-stage bio-aerosol sampler with a sampling flow rate of 170 L/min was designed and fabricated for sampling the bio-aerosols released during human breathing and coughing, and its performance was evaluated. The sampler was constructed using a cyclone separator with a cutoff size of 2.5 μm as a preseparator, a multinozzle virtual impactor with a cutoff size of 0.34 μm as an aerosol concentrator, and a Bio-Sampler, which is a commercial product, for collecting bio-aerosols in a collection fluid. The collection efficiency of the sampler was evaluated through simulations and experiments. Only particles with sizes of 0.1–4 μm were selectively collected in the collection fluid. Bacteriophage bio-aerosols were sampled using the developed sampler and ACD-200 Bobcat sampler, which is a commercial product. The amounts of collected bacteriophages were compared using the polymerase chain reaction (PCR) technique. The sampling performance of the developed sampler was similar to that of the ACD-200 Bobcat sampler. Moreover, the developed sampler showed its ability to sample bio-aerosols of a specific size range and collect them directly in a collection fluid for the PCR analysis. Therefore, the developed sampler is expected to be useful for indoor environmental monitoring by effectively sampling the bio-aerosols released indoors during human breathing and coughing.
Numerical and Experimental Investigations on Cross-Sensitivity Characteristics of Instrumented Wheelset Associated With Longitudinal Force and Lateral Contact Position
Authors: Hondo Takatoshi , Tanaka Takayuki , Kuniyuki Shoya , Suzuki Mitsugi 
Published: January 2022

Abstract
It is crucial to grasp wheel-rail contact forces in the evaluation of running safety and curving performance of railway vehicles. To measure the wheel-rail contact forces, instrumented wheelset, which has the strain gages on the wheel surface, is widely used. The purpose of this research is to increase the measurement accuracy of the wheel-rail contact forces by understanding the detailed characteristics of the instrumented wheelset. Although the various research works on the instrumented wheelset have been carried out to increase the measurement accuracy of wheel-rail contact forces, there are few works considering the longitudinal force and the lateral shift of the wheel-rail contact point. However, sometimes the longitudinal force has a non-negligible influence on the measurement accuracy on the instrumented wheelset. In this paper, the authors clarify the cross-sensitivity characteristics of the instrumented wheelset when the longitudinal force is applied to the various lateral position on the wheel tread through the finite element method (FEM) analysis and the static load test. The authors also propose a method to approximate the cross-sensitivity as an analytical function of the lateral and circumferential contact positions.
Modeling of Supercritical CO2 Shell-and-Tube Heat Exchangers Under Extreme Conditions: Part II: Heat Exchanger Model
Authors: Krishna Akshay Bharadwaj , Jin Kaiyuan , Ayyaswamy Portonovo S. , Catton Ivan , Fisher Timothy S. 
Published: January 2022

AbstractHeat exchangers play a critical role in supercritical CO2 Brayton cycles by providing necessary waste heat recovery. Supercritical CO2 thermal cycles potentially achieve higher energy density and thermal efficiency operating at elevated temperatures and pressures. Accurate and computationally efficient estimation of heat exchanger performance metrics at these conditions is important for the design and optimization of sCO2 systems and thermal cycles. In this paper (Part II), a computationally efficient and accurate numerical model is developed to predict the performance of shell-and-tube heat exchangers (STHXs). Highly accurate correlations reported in Part I of this study are utilized to improve the accuracy of performance predictions, and the concept of volume averaging is used to abstract the geometry and reduce computation time. The numerical model is validated by comparison with computational fluid dynamics (CFD) simulations and provides high accuracy and significantly lower computation time compared to existing numerical models. A preliminary optimization study is conducted and the advantage of using supercritical CO2 as a working fluid for energy systems is demonstrated.
The Feasibility of Using the Virtual Time-to-Contact Measure of Postural Stability to Examine Postural Recovery in People With Diabetes Mellitus
Authors: Lin Chia-Cheng , Kim Sunghan , DeVita Paul , Becker Matt , Meardon Stacey 
Published: January 2022

This study aimed to examine the feasibility of using time-to-contact measures during the perturbation protocol in people with diabetes mellitus. Three-dimension motion capture and force data were collected during 0.5-s perturbations in four directions (forward, backward, right, and left) and at two accelerations (20 and 40 cm/s2) to compute the time-to-contact. Time-to-contact analysis was divided into three phases: perturbation, initial recovery, and final recovery. The statistical analysis showed the main effects of Direction and Phase (p < .01) as well as a Direction by Phase interaction (p < .01). Backward perturbation with lower acceleration and backward/forward perturbation with higher acceleration had deleterious effects on postural stability in people with diabetes mellitus.
Serum complement component 3, complement component 4 and complement component 1q levels predict progressive visual field loss in older women with primary angle closure glaucoma
Authors: Li Shengjie , Qiu Yichao , Yu Jian , Shao Mingxi , Li Yingzhu , Cao Wenjun , Sun Xinghuai 
Published: January 2022

AimTo evaluate the association between serum levels of complement component (C) 3, C4 and C1q and visual field (VF) loss in patients with primary angle closure glaucoma (PACG).MethodsIn this prospective cohort study, a total of 308 patients with PACG were included. The patients were followed up every 6 months (at least 2 years), with clinical examination and VF testing. Based on their sex and age, the subjects were stratified into male and female subgroups, and by age at <60 and ≥60 years per subgroup.ResultsOne hundred twenty-three (39.94%) patients showed glaucoma VF progression. The serum levels of C3, C4 and C1q were significantly lower (p<0.05) in the progression group compared with the non-progression group in the ≥60 years female subgroup. In female patients with age ≥60 years, (1) lower levels of baseline C3 (HR=0.98, p<0.001), C4 (HR=0.96, p=0.01) and C1q levels (HR=0.99, p=0.003) were associated with a greater risk of VF progression; (2) patients with lower C3 levels had significantly (p<0.05) higher rates of VF loss progression, similar to those with lower C4 and lower C1q levels; and (3) the generalised additive model revealed a negative correlation between baseline C3 (p<0.001), C4 (p<0.001) and C1q (p<0.001) levels with the risk of VF progression. No statistical significance was observed in the male (<60 and ≥60 years) and female (<60 years) subgroups.ConclusionDecreased C3, C4 and C1q levels at baseline were significantly associated with a greater risk of VF loss progression only in older women with PACG.
Assessing knowledge and self-report intention from COVID-19 symptoms based on the Health Belief Model among international students in Heilongjiang, China: a cross-sectional study
Authors: Ismael Omar Yacouba , Li Yuanheng , Sha Zhuowa , Wu Qunhong , Wei Lifeng , Jiao Mingli , Li Ye , Shan Linghan , Wang Yushu 
Published: January 2022

BackgroundA COVID-19 outbreak has been contained in China through effective prevention measures with the collaboration of the citizens. However, there is resistance to self-reported symptoms as required in the international student community. This study explored knowledge level and symptoms reporting behaviours toward COVID-19 among international students.MethodsAn online cross-sectional investigation was conducted among 119 international students across Heilongjiang province and questionnaires implemented through WeChat between 1 and 25 March 2020. The results were explained using descriptive Χ2 test and binary logistic regression analysis using SPSS V.20.ResultsIn total, 119 international students participated, with a response rate of 90.16%. Of the 119 respondents, 96 (80.7%) knew COVID-19 symptoms, 109 (91.6%) took cognisance of questions on the importance of the maintenance of wearing masks and 113 (95%) on questions regarding hand hygiene in the prevention of disease transmission. However, results show that there were still large gaps in knowledge about questions regarding the virus and the treatment methods (many participants incorrectly believed that the virus could be kill by drinking alcohol or smoking). In addition, more than half of the participants declared compliance with positive health behaviours, however 27.7% did not agree with vaccination (if any), and 31.1% did not agree to be quarantined after being diagnosed with COVID-19. Furthermore, 20 participants (16, 80%) expressed an inclination to deliberately withhold symptoms. Variables in the Health Belief Model showed a significant association with behavioural change.ConclusionFrom our study, we found that there is evident knowledge about COVID-19 among international students, although orientation and sensitisation are still required. Those who were aware of the benefits of reporting, the severity of COVID-19 and the legal consequences of deliberately concealing information showed a greater willingness to report; conversely, those who believed reporting is very inconvenient and feared being quarantined after reporting showed less willingness to report. A study focusing on international students’ knowledge and behaviour amid the pandemic will provide information for countries to cut off the chain of disease transmission of all variants of COVID-19.
Do partnership dissolutions and living alone affect systemic chronic inflammation? A cohort study of Danish adults
Authors: Davidsen Karolina , Carstensen Simon , Kriegbaum Margit , Bruunsgaard Helle , Lund Rikke 
Published: January 2022

BackgroundPartnership breakups and living alone are associated with several adverse health outcomes. The aim of this study, carried out in Denmark, is to investigate whether accumulated numbers of divorces/partnership breakups or years lived alone across 26 years of adult life are associated with levels of inflammation, and if vulnerability with regards to gender or educational level can be identified.Methods4835 participants from the Copenhagen Aging and Midlife Biobank (CAMB) aged 48–62 years were included. Data on accumulated numbers of partnership breakups and years living alone were retrieved from a national standardised annual register. Inflammatory markers interleukin 6 (IL-6) and high sensitivity C-reactive protein (hsCRP) were measured in blood samples. Multivariate linear regression analyses were adjusted for age, educational level, early major life events, body mass index, chronic diseases, medicinal intake affecting inflammation, acute inflammation and personality scores.ResultsFor men, an association was found between an increasing number of partnership breakups or number of years living alone and higher levels of inflammatory markers. No such association was found for women, and no evidence of partnership breakups and educational level having a joint effect was found for either gender.ConclusionThe findings suggest a strong association between years lived alone or accumulated number of partnership breakups and low-grade inflammation for middle-aged men, but not for women. Among those of either sex with a lower level of education, no specific vulnerability to accumulated years lived alone or number of breakups was identified.
Pembrolizumab and decitabine for refractory or relapsed acute myeloid leukemia
Authors: Goswami Meghali , Gui Gege , Dillon Laura W , Lindblad Katherine E , Thompson Julie , Valdez Janet , Kim Dong-Yun , Ghannam Jack Y , Oetjen Karolyn A , Destefano Christin B , Smith Dana M , Tekleab Hanna , Li Yeusheng , Dagur Pradeep , Hughes Thomas , Marté Jennifer L , del Rivero Jaydira , Klubo-Gwiezdzinksa Joanna , Gulley James L , Calvo Katherine R , Lai Catherine , Hourigan Christopher S 
Published: January 2022

BackgroundThe powerful ‘graft versus leukemia’ effect thought partly responsible for the therapeutic effect of allogeneic hematopoietic cell transplantation in acute myeloid leukemia (AML) provides rationale for investigation of immune-based therapies in this high-risk blood cancer. There is considerable preclinical evidence for potential synergy between PD-1 immune checkpoint blockade and the hypomethylating agents already commonly used for this disease.MethodsWe report here the results of 17 H-0026 (PD-AML,NCT02996474), an investigator sponsored, single-institution, single-arm open-label 10-subject pilot study to test the feasibility of the first-in-human combination of pembrolizumab and decitabine in adult patients with refractory or relapsed AML (R-AML).ResultsIn this cohort of previously treated patients, this novel combination of anti-PD-1 and hypomethylating therapy was feasible and associated with a best response of stable disease or better in 6 of 10 patients. Considerable immunological changes were identified using T cell receptor β sequencing as well as single-cell immunophenotypic and RNA expression analyses on sorted CD3+ T cells in patients who developed immune-related adverse events (irAEs) during treatment. Clonal T cell expansions occurred at irAE onset; single-cell sequencing demonstrated that these expanded clones were predominately CD8+ effector memory T cells with high cell surface PD-1 expression and transcriptional profiles indicative of activation and cytotoxicity. In contrast, no such distinctive immune changes were detectable in those experiencing a measurable antileukemic response during treatment.ConclusionAddition of pembrolizumab to 10-day decitabine therapy was clinically feasible in patients with R-AML, with immunological changes from PD-1 blockade observed in patients experiencing irAEs.
G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes
Authors: Lu Chunwan , Yang Dafeng , Klement John D , Colson Yolonda L , Oberlies Nicholas H , Pearce Cedric J , Colby Aaron H , Grinstaff Mark W , Ding Han-Fei , Shi Huidong , Liu Kebin 
Published: January 2022

BackgroundGranzyme B is a key effector of cytotoxic T lymphocytes (CTLs), and its expression level positively correlates with the response of patients with mesothelioma to immune checkpoint inhibitor immunotherapy. Whether metabolic pathways regulateGzmbexpression in CTLs is incompletely understood.MethodsA tumor-specific CTL and tumor coculture model and a tumor-bearing mouse model were used to determine the role of glucose-6-phosphate dehydrogenase (G6PD) in CTL function and tumor immune evasion. A link between granzyme B expression and patient survival was analyzed in human patients with epithelioid mesothelioma.ResultsMesothelioma cells alone are sufficient to activate tumor-specific CTLs and to enhance aerobic glycolysis to induce a PD-1hiGzmbloCTL phenotype. However, inhibition of lactate dehydrogenase A, the key enzyme of the aerobic glycolysis pathway, has no significant effect on tumor-induced CTL activation. Tumor cells induce H3K9me3 deposition at the promoter ofG6pd, the gene that encodes the rate-limiting enzyme G6PD in the pentose phosphate pathway, to downregulateG6pdexpression in tumor-specific CTLs. G6PD activation increases acetyl-coenzyme A (CoA) production to increase H3K9ac deposition at theGzmbpromoter and to increaseGzmbexpression in tumor-specific CTLs converting them from a Gzmbloto a Gzmbhiphenotype, thus increasing CTL tumor lytic activity. Activation of G6PD increases Gzmb+tumor-specific CTLs and suppresses tumor growth in tumor-bearing mice. Consistent with these findings,GZMBexpression level was found to correlate with increased survival in patients with epithelioid mesothelioma.ConclusionG6PD is a metabolic checkpoint in tumor-activated CTLs. The H3K9me3/G6PD/acetyl-CoA/H3K9ac/Gzmb pathway is particularly important in CTL activation and immune evasion in epithelioid mesothelioma.