bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic vein insufficiency correction in patients with lower extremities varicosity and knee osteoarthritis
Authors: Shcheglov E. A. , Alontseva N. N. 
Published: November 2022

Introduction. Chronic vein diseases in general and varicose veins of the lower extremities in particular represent a serious medical and social problem.The aim was to study the influence of the therapy of venous outflow disorders on the treatment results of osteoarthritis of the knee joints in patients with varicose veins in combination with osteoarthritis of the knee joints.Materials and methods. The study included 105 patients with varicose veins combined with knee osteoarthritis who had previously received treatment for osteoarthritis of the knee joints but had not received or had received extremely irregular therapy for varicose veins. The follow-up period for the patients was 12 months. The patients underwent the first course of phlebotropic drugs for 2 months from the start of the study. Then this course was repeated twice at 3-month intervals. The standard phlebotropic drug was a micronized purified flavonoid fraction. Compression knitwear was recommended in all patients. Class 2 stockings or tights with an ankle pressure of 23–32 mmHg were used in the vast majority of cases. Treatment of osteoarthritis included the use of nonsteroidal anti-inflammatory drugs, disease-modifying agents (chondroitin sulfate, glucosamine sulfate), and physical therapy.Results. The VCSS scale reduced the degree of chronic venous insufficiency in the clinical group. At inclusion in the study, the average score in the clinical group was 7.1 ± 1.9, after 6 months the result was 6.1 ± 1.5, and after 12 months – 6.0 ± 1.2 points. In the control group, where patients did not receive therapy for varicose veins, there were no dynamics. The results of joint syndrome against the background of correction of venous outflow disturbances – decrease of Leken and WOMAC index values, decrease of pain syndrome according to the visual analogue scale. All this led to a decrease in the patients' need for taking analgesics.Conclusions. Out of 100 patients with joint pathology, 68 patients were diagnosed with varicose veins. These diseases aggravate each other, but we can assume that the venous pathology is primary. A vicious circle is set in motion – progression of osteoarthritis due to the disturbances of venous outflow, and varicosity due to the deterioration of muscular-venous pump functioning.
Risk of sarcopenia after bariatric surgery in patients with type 2 diabetes mellitus
Authors: Khitaryan A. G. , Abovyan A. A. , Mezhunts A. V. , Orekhov A. A. , Melnikov D. A. , Sarkisyan А. V. , Adizov S. A. , Rogut A. A. , Ziegler G. J. , Amegninou C. M.J. 
Published: November 2022

Introduction. Despite the great popularity of Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy in the treatment of morbid obesity, the problem of the development and progression of sarcopenia in patients with type 2 diabetes mellitus in the postoperative period remains insufficiently studied.Aim. To study the prevalence and dynamics of sarcopenia in patients with type 2 diabetes mellitus after Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy in the long term.Materials and methods. Our prospective study included 257 bariatric patients (170 Roux-en-Y gastric bypass and 87 laparoscopic sleeve gastrectomy) with type 2 diabetes mellitus. All patients underwent a standard set of preoperative examination with obligatory determination of the skeletal muscle mass index using the bioelectrical impedance analysis. After 6, 12, 18 and 24 months, control examinations were carried out.Results. At the preoperative stage, 28 patients (16.5%) with signs of moderate sarcopenia were identified in the Roux-en-Y gastric bypass group and 15 patients (17.2%) in the laparoscopic sleeve gastrectomy group. According to the bioelectrical impedance analysis, 24 months after the operation, 37 patients (25.9%) with signs of moderate sarcopenia and 2 patients (1.4%) with severe sarcopenia were identified in the first group. 24 months after surgery in the second group there was no statistical difference in the number of patients with signs of sarcopenia in comparison with the preoperative period.Conclusion. The frequency of development and progression of signs of sarcopenia after Roux-en-Y gastric bypass is statistically higher than after laparoscopic sleeve gastrectomy. In this regard, in our opinion, when choosing a method of surgical treatment of morbid obesity with concomitant type 2 diabetes mellitus, a detailed assessment of the state of protein metabolism by the bioelectrical impedance analysis is necessary.
The significance of minimally invasive treatment methods in the single-stage elimination of varicose vein disease of the great and small saphenous veins of the lower limbs and their branches
Authors: Alukhanyan O. A. , Gabibullaev R. E. , Alukhanyan A. O. , Kurganskiy O. V. , Aristov D. S. 
Published: November 2022

Introduction. This article presents a clinical case of successful and single-stage endovenous laser coagulation combined with miniphlebectomy in a patient with extensive and combined varicose lesion of all major subcutaneous veins of the lower limbs with significant symptoms of chronic venous insufficiency.Aim. To determine the possibilities of simultaneous elimination of all main subcutaneous veins and their varicose tributaries on both lower limbs using minimally invasive methods.Materials and methods. A 44-year-old female patient complained of gastrocnemius muscle cramps, swollen shins, feeling of heaviness at the end of the working day and the presence of varicose veins in both lower extremities. The severity of the chronic vein disease before the intervention according to the VCSS (Venous clinical Severity Score) was 8. As a result, patency of deep veins and condition of their valve apparatus, insufficiency of valves of the sapheno-femoral and sapheno-popliteal annexes on both sides with reflux through large and small saphenous veins and anterior accessory large saphenous vein on the right, insufficiency of perforating veins of both tibias were determined. Endovenous laser coagulation of the great and small saphenous veins on both sides and the right anterior accessory great saphenous vein, miniphlebectomy of dilated tributaries within both lower limbs was performed. The symptoms of chronic venous insufficiency decreased markedly. Swelling of the lower legs and cramps in the gastrocnemiu muscles have almost completely disappeared, and the feeling of heaviness in the legs after static loads has significantly decreased.Conclusion. Endovenous laser coagulation with miniphlebectomy should be given preference in varicose vein disease with combined affection of all great saphenous veins of both lower limbs. Their application provides an opportunity to eliminate simultaneously incompetence of all target veins and to remove varicose dilated tributaries, providing good therapeutic and cosmetic effect without hospitalization and detachment of the patient from his or her work activity.
Prevention of relapses of varicose veins in patients with true doubling of the great saphenous vein
Authors: Chernookov A. I. , Kuznetsov M. R. , Kandyba S. I. , Dolgov S. I. , Atayan A. A. , Ramazanov А. A. 
Published: November 2022

Introduction. True doubling of great saphenous vein is observed in 1.6–2.1% of patients with varicose veins and may be one of the reasons for the development of postoperative relapse of the disease. Performing endovasal laser coagulation (EVLC) of both great saphenous vein trunks makes it possible to increase the radicality of the intervention and reduce the likelihood of a recurrence of varicose veins.Aim. Based on the study of immediate and long-term results, to substantiate the expediency of using EVLC of the main and true additional stem of great saphenous vein in patients with varicose veins.Materials and methods. From 2014 to 2020, 24 patients with a true doubling of great saphenous vein were treated. Among the applicants there were 12 women and 12 men aged 23 to 62 years with clinical class C2–C4 according to the CEAP (Clinical, Etiologic, Anatomic, Pathophysiologic) classification. All patients under tumescent anesthesia underwent simultaneous EVLC of the main and accessory trunk of the BPV, followed by miniflebectomy or sclerobliteration of varicose tributaries.Results and discussion. The use of simultaneous coagulation of both trunks was performed by all patients, thus the technical success of the operation was observed in 100% of cases. There were no intraoperative complications. The use of such a volume of intervention is accompanied by an increase in the duration of the operation by 29.3%. Hyperpigmentation in the projection of the coagulated trunk was observed in 2 (8.3%) patients, neurological disorders – in 1 (4.2%) patient. During the examination of patients 1–2 years after the operation, no relapses of the disease were detected, and the cosmetic result of the intervention on a ten-point scale, patients on average estimated at 7.6 points.Conclusions. True doubling of the great saphenous vein is rare and may increase the likelihood of relapses of the disease. EVLC of the main and additional BPV trunks is accompanied by an increase in the duration of surgery by an average of 29.3%, and the number of patients with hyperpigmentation by 1.5 times. Simultaneous EVLC of both tables with true duplication of BPV makes it possible to reliably block a potential source of varicose disease recurrence and reduce the likelihood of recurrent veins.
Modern approach to the choice of laxative agent in surgical interventions in outpatient coloproctology
Authors: Belik B. M. , Kovalev A. N. 
Published: November 2022

Introduction. Elimination of manifestations of functional constipation and normalization of the stool to date remain a complex and finally unresolved problem during typical surgical interventions in outpatient coloproctology.Aim. To evaluate the clinical efficacy of the laxative agent sodium picosulfate in the surgical treatment of non-tumor diseases of the anal canal and rectum in outpatient settings.Materials and methods. The results of surgical treatment of 566 patients with non-tumor diseases of the anal canal and rectum, which were divided into two groups, were analyzed. In 275 patients (group 1), laxative agents were not used during treatment or were used indiscriminately. In 291 patients (group 2), the laxative agent sodium picosulfate was used to normalize colon emptying and soften stools during treatment. Comparison criteria: level of pain syndrome after surgery, degree of inflammatory manifestations in the field of surgical intervention, shape, and nature of fecal masses (based on the Bristol scale), frequency of wound inflammatory complications and recovery time for patients.Results. In the early stages after surgery, the stool had a softened consistency (type 5 and 6) in a much larger number of group 2 patients (89.7 ± 4.1 – 94.2 ± 5.1%) compared with group 1 patients (67.3 ± 4.8 – 76.7 ± 4.9%). At the same time, in group 2 patients, pain syndrome was less pronounced, inflammatory manifestations in the area of surgical intervention regressed faster, incidence of wound inflammatory complications decreased 2.8 times (from 16.4 to 5.8%) and work capacity was recovered earlier than in group 1 patients.Conclusion. The use of the laxative agent sodium picosulfate in coloproctological patients when performing typical surgical interventions on the rectum and anal canal on an outpatient basis eliminates the manifestations of symptomatic constipation, ensures the formation of a softened stool in perioperative periods, reduces mechanical injury to the mucous membrane of the rectum by feces, reduces the level of pain syndrome, which improves the results of surgical treatment by reducing the number of wound inflammatory complications.
Rectangular top-hinged plate as portable flow measuring device
Authors: Gorgin Faraz , Vatankhah Ali R. 
Published: November 2022

Abstract
Most previous studies have focused on adjustable complex flap gates and little research has been carried out on simple inline top-hinged plates for flow measurement. The present study investigates discharge measurement by top-hinged plates located along channels under free flow condition. The proposed simple device is a portable one. Two discharge models are proposed based on Buckingham's theorem of dimensional analysis. The first model (Model I) considers deflection angle as an independent variable while the second model (Model II) considers it as a dependent variable. A series of laboratory experiments (687 runs) were performed to calibrate the proposed models. The results showed that when the slope of the channel increases, the accuracy of the proposed model slightly decreases. The first model has an average error of 2.32%, while the second model has an average error of 3.19%, thus flow discharge through the rectangular channels with longitudinal slopes in range of [0, 0.005] can be accurately estimated using the proposed discharge models. Based on this experimental study, the plate length enhances the performance of the second model when the mass plate is unknown. The proposed device offers a simple and reliable discharge measurement approach for both horizontal and sloping rectangular channels.
Integration of a pure moving bed biofilm reactor process into a large micro-polluted water treatment plant
Authors: Han Wenjie , Zhou Jiazhong , Sheng Deyang , Wu Di , Zhou Haoran , Yang Zhongqi , Yin Jianwen , Xia Chao , Kan Yujiao , He Junguo 
Published: November 2022

Abstract
The pure-MBBR process was applied to remove ammonia in a full-scale micro-polluted-water treatment plant with a daily treatment capacity of 260 × 104 m3/d, Guangdong, China. The relationship between treatment efficiency, physical and chemical properties and microbial diversity in the process of biofilm growth was explored, and the oxygen transfer model of biofilm was established. The results show that the effluent of two-stage pure MBBR process is stable and up to standard after 10 days' incubation. The nitrification loads of two-stage biofilm was stable on the 14th day. The biomass and biofilm thickness lagged behind the nitrification load, and reached a relatively stable level on the 28th day. The species richness of biofilm basically reached a stable level on the 21st day, and the microbial diversity of primary biofilm was higher. In the primary and secondary stage at different periods, the relative abundance of dominant nitrifying bacteria Nitrospira reaches 8.48–13.60%, 6.48–9.27%, and Nitrosomonas reaches 2.89–5.64%, 0.00–3.48%. The pure MBBR system mainly adopts perforated aeration. Through the cutting and blocking of bubbles by suspended carriers, the oxygen transfer rate of the system was greatly improved.
Inactivation of antibiotic resistant bacteria from stormwater runoff using UVA/LED and its potential risks
Authors: Li Ting , Zuo XiaoJun , Zhang SongHu , Kong QingGang 
Published: November 2022

Abstract
Recently, increasing attention has been paid to antibiotic resistance in stormwater runoff. However, there is no available literature about the control of antibiotic resistant bacteria (ARB) through 365 nm ultraviolet light-emitting diode (UVA/LED). In this study, batch experiments were conducted to investigate ARB inactivation kinetics, effects of light intensity and water matrix (including suspended solid (SS) concentration, initial pH and bacteria concentration), and potential transmission risks after UVA/LED irradiation. Results showed that ARB inactivation efficiencies reached 6.31 log reduction at 8 mW/cm2 (86 J/cm2) of UVA/LED for 180 min. ARB inactivation efficiencies increased with the increase of light intensity, and showed a linear relationship. ARB inactivation decreased with increasing SS levels, and the largest inactivation efficiencies was 3.56 log reduction at 50 mg/L of SS. Initial pH had slight effect on ARB inactivation through UVA/LED irradiation. A low initial bacteria concentration (105 CFU/mL) was not necessarily associated with good ARB inactivation (3.59 log reduction). After UVA/LED irradiation, ARB was hardly detected during 12 hr of dark repair, and the transfer frequency of kanamycin resistance gene was increased to 5.43 × 10−4. These suggested that the application of UVA/LED to inactivate ARB in stormwater runoff was feasible and desirable in this study.
Russian high-tech exports To the EAEU and BRICS countries and the potential to enter new commodity markets
Authors: Izutina T. A. 
Published: November 2022

Today the basis of exports from Russia are goods of the fuel and energy group. However, due to the instability of prices in the oil and gas markets, as well as the spreading policy of introducing environmentally friendly energy sources around the world, there is a need to diversify Russian exports and shift them towards non-commodity goods. The key task set by the President of the Russian Federation V. V. Putin before the Government of the Russian Federation is to ensure a breakthrough growth in the export of goods with high added value, including the achievement by 2030 of 70% of the share of non-primary sector goods in total exports from Russia. In this article, the author considers the top 20 groups of high value added goods exported by Russia to the world market, separately considers the lists of high value products supplied to the EAEU and BRICS countries, compares Russia's global exports with supplies to the EAEU and BRICS countries. By applying the Balassa index, an assessment of the comparative advantage of Russia in terms of commodity items, identified by the author as a priority for the initial release to new markets, is given. Based on the data obtained, the author draws conclusions about the prospects for the export of upper value added goods to new markets in Russia, including the identification of specific product groups, the export of which can be expanded.
Effects of Bardoxolone Methyl in Alport Syndrome
Authors: Warady Bradley A. , Pergola Pablo E. , Agarwal Rajiv , Andreoli Sharon , Appel Gerald B. , Bangalore Sripal , Block Geoffrey A. , Chapman Arlene B. , Chin Melanie P. , Gibson Keisha L. , Goldsberry Angie , Iijima Kazumoto , Inker Lesley A. , Kashtan Clifford E. , Knebelmann Bertrand , Mariani Laura H. , Meyer Colin J. , Nozu Kandai , O’Grady Megan , Rheault Michelle N. , Silva Arnold L. , Stenvinkel Peter , Torra Roser , Chertow Glenn M. 
Published: November 2022

Background and objectives
Alport syndrome is an inherited disease characterized by progressive loss of kidney function. We aimed to evaluate the safety and efficacy of bardoxolone methyl in patients with Alport syndrome.

Design, setting, participants, & measurements
We randomly assigned patients with Alport syndrome, ages 12–70 years and eGFR 30–90 ml/min per 1.73 m2, to bardoxolone methyl (n=77) or placebo (n=80). Primary efficacy end points were change from baseline in eGFR at weeks 48 and 100. Key secondary efficacy end points were change from baseline in eGFR at weeks 52 and 104, after an intended 4 weeks off treatment. Safety was assessed by monitoring for adverse events and change from baseline in vital signs, 12-lead electrocardiograms, laboratory measurements (including, but not limited to, aminotransferases, urinary albumin-creatinine ratio, magnesium, and B-type natriuretic peptide), and body weight.

Results
Patients randomized to bardoxolone methyl experienced preservation in eGFR relative to placebo at 48 and 100 weeks (between-group differences: 9.2 [97.5% confidence interval, 5.1 to 13.4; P<0.001] and 7.4 [95% confidence interval, 3.1 to 11.7; P=0.0008] ml/min per 1.73 m2, respectively). After a 4-week off-treatment period, corresponding mean differences in eGFR were 5.4 (97.5% confidence interval, 1.8 to 9.1; P<0.001) and 4.4 (95% confidence interval, 0.7 to 8.1; P=0.02) ml/min per 1.73 m2 at 52 and 104 weeks, respectively. In a post hoc analysis with no imputation of missing eGFR data, the difference at week 104 was not statistically significant (1.5 [95% confidence interval, −1.9 to 4.9] ml/min per 1.73 m2). Discontinuations from treatment were more frequent among patients randomized to bardoxolone methyl; most discontinuations were due to protocol-specified criteria being met for increases in serum transaminases. Serious adverse events were more frequent among patients randomized to placebo. Three patients in each group developed kidney failure.

Conclusions
In adolescent and adult patients with Alport syndrome receiving standard of care, treatment with bardoxolone methyl resulted in preservation in eGFR relative to placebo after a 2-year study period; off-treatment results using all available data were not significantly different.

Clinical Trial registry name and registration number:
A Phase 2/3 Trial of the Efficacy and Safety of Bardoxolone Methyl in Patients with Alport Syndrome - CARDINAL (CARDINAL), NCT03019185
Translation of Superheroes’ Names from English into Lithuanian in the Animated Series "The Venture Bros."
Authors: Kulikauskaitė Lina , Maskaliūnienė Nijolė 
Published: November 2022

In the article the focus is on the translation of superheroes’ names in the subtitles of the first seven episodes of The Venture Bros., a dark humour cartoon parody of the superhero genre. The aim is to see what translation strategies were used for their translation from English into Lithuanian. This kind of translation of proper names is problematic because of several reasons: (1) proper names belong to a special layer of cultural words in the source language that are usually treated as non-equivalent lexis in the target language; (2) the parody genre determines the connotations of the character names used; (3) subtitles themselves restrict a translator’s choices due to the technicalities of this type of audiovisual translation. The character names included in the analysis were categorised into reoccurring character names (32) and background character names (19). Most of the former were translated by way of loan translation due to their rich connotations while background characters were mostly rendered by transcription as they are usually regular proper names rather than symbolic names with semantic or connotative value. And although some strategies were used more frequently than others, the choice of the strategy was predetermined by the contextual information of the occurrence, which leads to the conclusion that even very similar names can be translated using different translation strategies when the context is taken into consideration.
Semantic Fields in Selected Poems from "Season Songs" by Ted Hughes
Authors: Lapa Lauma Tereze 
Published: November 2022

Ted Hughes (1930–1998), the Poet Laureate (1984–1998) wrote a collection entitled Season Songs, originally intended for child audience. Analysis of the obvious semantic fields in three selected poems from the collection shows that the poems possess more than the aspects intended for children – alongside observation of the season and nature, they point also at transcendent values and experiences beyond and outside childhood.