bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central and Autonomic Mechanisms of the Development of Benign Dyshormonal Diseases of the Mammary Glands
Authors: Подольский Вл.В. , Подольский В.В. 
Published: February 2022

В статье представлен анализ литературных данных о причинах возникновения доброкачественных дисгормональных заболеваний молочных желез. Описаны механизмы регуляции выработки и секреции пролактина. Определены основные патогенетические звенья регуляции секреции пролактина со стороны центральной и вегетативной нервной системы. Предложены возможности коррекции и профилактики образования доброкачественных дисгормональных заболеваний молочных желез у женщин фертильного возраста.
The article presents an analysis of the literature on the causes of benign breast diseases. Mechanisms of regulation of prolactin production and secretion are described. The main pathogenetic links of regulation of prolactin secretion by the central and autonomic nervous system are determined. Possibilities of correction and prevention of formation of benign diseases of mammary glands at women of childbearing age are offered.
Clinical and Psychological Factors that Influence the Assessment of the Quality of Life by Patients with Somatoform Disorders
Authors: Мороз С.М. , Макарова И.И. , Семенихина В.Е. 
Published: February 2022

Определены факторы, обусловливающие снижение интегрального показателя качества жизни у пациентов с соматоформными расстройствами. Обследовано 320 пациентов, у всех у них выявлено снижение качества жизни, определена тактика выбора симптомов-мишеней терапевтической работы.
The factors that cause the decrease of the integral indicator of the quality of life in patients with somatoform disorders were determined. A total of 320 patients were examined. Decrease of the quality of life was found in all patients, and the tactics of selection of target symptoms of therapeutic work was determined.
Teething Syndrome in Children: What Should Doctor Know?
Authors: Бекетова Г.В. , Горячева И.П. 
Published: February 2022

Статья посвящена проблеме прорезывания зубов у детей. Основываясь на данных международных аналитических обзоров, авторы представили современные взгляды на клинические проявления процесса, их взаимосвязь с физиологическим периодом дентации. В работе рассмотрены актуальные подходы к решению данной проблемы, проанализированы способы коррекции ведущих признаков и симптомов, применение нефармакологических и фармакологических средств с оценкой их эффективности и безопасности при купировании боли в периоде дентации у младенцев. Авторами представлены данные о возможных рисках и негативных последствиях использования местных анестетиков на основе бензокаина, лидокаина, гомеопатических средств при прорезывании молочных зубов у детей раннего возраста.
Article is devoted to the issue of teething in children. On the base of the data of international analytical reviews, the authors present modern views on clinical manifestations of teething as well as the relationship of the latter with the physiological period of teething. In the paper, there are considered current approaches to observation of infants, analyzed the ways to correct the main signs and symptoms, and assessed the effectiveness and safety of non-pharmacological and pharmacological agents in the management of pain during teething in infants. The authors present data on the possible risks and negative consequences of the use of local anesthetics based on benzocaine, lidocaine and homeopathic remedies for teething of milk teeth in young children.
Markers of Apoptosis for Diagnosing and Predicting of Progression of Glomerulopathies in Children: Literature Review
Authors: Маховская Т.А. , Козыро И.А. , Сукало А.В. 
Published: February 2022

Представлен обзор литературных данных о факторах, участвующих в патогенезе и прогрессировании гломерулопатий. При повреждении почек работают две большие группы факторов - иммунные (антитела и иммунные комплексы) и неиммунные (системная и почечная гипертензия, дислипидемия, протеинурия). Дисбаланс между процессами пролиферации и апоптоза в почечной ткани, пытающейся адаптироваться к работе в условиях повреждения, - важнейший механизм дальнейшего прогрессирования гломерулопатии. В статье приводятся современные представления о процессе апоптоза, включающем три стадии: индукторную, эффекторную и деградационную. Рассмотрены маркеры запрограммированной клеточной гибели, которые можно обнаружить в крови и моче пациентов (гранзим Б, sFas/sAPO-1, sFas-L, цитокератин-18, аннексин V). Приведены данные последних исследований, изучавших уровни этих молекул у пациентов с различными патологиями. Также рассматривается эндотелиальная дисфункция как возможный значимый фактор в прогнозировании исходов почечной патологии.
Review of the literature data on the factors involved in the pathogenesis and progression of glomerulopathies is presented. Two large groups of factors work in kidney damage - immune (antibodies and immune complexes) and non-immune (systemic and renal hypertension, dyslipidemia, proteinuria) ones. The imbalance between the processes of proliferation and apoptosis in renal tissue trying to adapt to work in case of damage is the most important mechanism for further progression of glomerulopathy. The article presents modern ideas about the process of apoptosis, which includes three stages: induction, effector and degradation. The markers of programmed cell death that can be detected in the blood and urine of patients (granzyme B, sFas/sAPO-1, sFas-L, cytokeratin-18, annexin V) are considered. The data from recent studies that examined the levels of these molecules in patients with various pathologies are presented. Endothelial dysfunction is also considered as a possible significant factor in predicting the outcomes of renal pathology.
Procuramiento y uso de aloinjertos cutáneos de piel total criopreservados obtenidos de pacientes sometidas a abdominoplastía
Authors: FONSECA CANTEROS MARCELO ANDRES , CAÑETE SOTO ALDO , IBACETA ORLANDINI DINO , GOMEZ AGUILERA JENNIFER , SANTANDER MATURANA MÓNICA , ACUÑA SALAZAR PAULINA , MANDRIAZA MUÑOZ LUANA , VIDAL NEYEZ PAMELA , MOYA DELGADO MANUEL , VIVAS ROSALES GIOVANNI , DELGADO CARCAMO NICOLLE , DISI PARGA FLORENCIA , VASQUEZ HERRERA PAULA , OLIVARES CORCO JUAN , BUCHROITHNER HAASE CATALINA 
Published: February 2022

Introducción: Los aloinjeros cutáneos (AC) son excelentes sustitutos cutáneos temporales, sin embargo, la donación y procura de piel cadavérica, fuente habitual de AC, es baja. Objetivo: Evaluar la factibilidad de utilizar la piel proveniente de abdominoplastías como fuente de AC y su eficacia clínica. Materiales y Método: Entre el 17 de agosto de 2020 al 28 de febrero de 2021, se analizó una corte prospectiva de 14 pacientes femeninas sometidas a abdominoplastía por motivos estéticos, que aceptaron donar la piel del colgajo cutáneo abdominal redundante, la cual fue criopreservada. Se utilizaron los AC de piel total (ACPT) en 10 pacientes con diagnósticos de: pie diabético (4), laparostomía contenida (2) herida compleja extremidad inferior (2), sarcoma de cuero cabelludo recidivado (1) y melanoma (1). Resultados: Se obtuvieron 14 colgajos de piel total, los cuales fueron procesados obteniendo una superficie promedio de 302 cm2 y 8,3 láminas de distintos tamaños de utilidad clínica por paciente. En todos los pacientes en que se utilizó ACPT hubo un prendimiento inicial del AC para posteriormente, en promedio 21 días, presentar una escara necrótica que al ser retirada presentaba un tejido vital adherido al receptor rico en fibroblastos, siendo algunos pacientes auto injertados y otros manejados con cicatrización por segunda intención como tratamiento definitivo. Discusión: Los ACPT proporcionan una cobertura intermedia, pues una parte se integra en forma definitiva, actuando como un andamiaje biológico para la formación de una interfase sobre la cual se puede autoinjertar o dejar evolucionar con cicatrización por segunda intención y una parte es rechazada. Conclusión: La procura de piel de donante vivo, en pacientes sometidos a cirugías de contorno corporal es un proceso factible, fuente de ACPT, los cuales permiten una nueva cobertura intermedia con múltiples aplicaciones clínicas.
Hepatectomía derecha totalmente laparoscópica para trasplante hepático con donante vivo adulto-adulto. Técnica quirúrgica y experiencia inicial en Chile.
Authors: Gamez del Mauro Brenda Andrea , Buckel Gonzalez Erwin , Puelma Calvo Felipe , Buckel Schaffner Erwin , Astorga Larrondo Cristian , Jarufe Cassis Nicolas 
Published: February 2022

El trasplante hepático con donante vivo (THDV) es un procedimiento complejo y desafiante para el cirujano, ya que exige garantizar tanto la máxima seguridad para el donante, así como también, la mejor calidad del injerto para el receptor. Debido a lo anterior, la implementación de la cirugía mini-invasiva ha sido lenta en esta área. Sin embargo, los ultimos 10 años, gracias a los avances que ha experimentado la cirugía hepática laparoscópica, ha aumentado el interés de algunos grupos altamente especializados por incorporar la cirugía mini-invasiva a la cirugía del donante, principalmente en trasplante hepático donante vivo adulto-pediatrico (THDVA-P). Los favorables resultados obtenidos en esta área, incluso han llevado a los expertos en el tema, a categorizar el abordaje laparoscópico para la cirugía del donante como el procedimiento estandar en THDVA-P. Contrario a lo anterior, la implementación de la laparoscopía para trasplante hepático donante vivo adulto-adulto (THDVA-A), es más compleja y requiere en su mayoría, una hepatectomía de lóbulo derecho o izquierdo para cumplir con las necesidades volumétricas del receptor. Esta cirugía es de mayor dificultad y riesgo para el donante, por lo que su indicación por vía mini-invasiva está limitada a centros de alto volumen y preparación, tanto en laparoscopía, como en trasplante hepático. En este trabajo, se busca dar a conocer la técnica quirúrgica y nuestra experiencia inicial con la primera hepatectomía derecha totalmente laparoscópica (HDTL) para THDVA-A realizada en Chile. Palabras clave: Trasplante hepático; Donante vivo; Hepatectomía derecha; Laparoscopía
Comparing the effectiveness of static stretching and proprioceptive neuromuscular facilitation stretching in treating delayed onset muscle soreness in calf muscles of runners
Authors: Sohail M. Ammar Ahmad , Tahir Ramesha , Maqbool Ayesha , Hanif Sana , Saeed Osama 
Published: February 2022

Objectives: To evaluate the comparative effectiveness of proprioceptive neuromuscular facilitation (PNF) and static stretching in relieving pain, increasing range of motion and improving functional disability in runners suffering from calf muscle delayed onset muscle soreness (DOMS).
Methodology: In this randomized controlled trial a sample size of 48 patients was taken from various gymnasiums of Faisalabad which were randomly allocated into 3 groups. Group A (n=16) received static stretching, Group B (n=16) received PNF stretching and Group C (n=16) received no intervention being the passive control group. Patients’ pain, range of motion (ROM) and lower extremity functional scale (LEFS) were assessed every 24 h after onset of DOMS for 5 days.
Results: No significant difference of age was observed between all groups. Significant improvement was demonstrated in all outcome measures across 5 days of treatment in subjects of all 3 groups with p < 0.05 by using Repeated Measures analysis of variance (ANOVA). Results of one–way ANOVA demonstrated significant improvement in all outcome measures including pain, range of motion and lower extremity functional scale. But most significant improvement was observed in the PNF group.
Conclusion: PNF stretching has proved to be relatively more effective than static stretching in reducing pain and improving range of motion and lower extremity functional scale scores in runners suffering from calf muscle DOMS.
Abbreviations: PNF - proprioceptive neuromuscular facilitation; DOMS - delayed onset muscle soreness; ROM - range of motion; LEFS - lower extremity functional scale; OTS - overtraining syndrome; EAMS - exercise associated muscle cramp; EIMD - exercise induced muscle damage; NPRS - numerical pain rating scale; HSD - "honestly significant difference”; GTO - Golgi Tendon Organs
Key words: Muscle soreness; Myalgia; Muscular cramp; Proprioceptive neuromuscular facilitation; PNF; Stretching; Muscle stretching exercise; Static active stretching
Citation: Sohail MAA, Tahir R, Maqbool A, Hanif S, Saeed O. Comparing the effectiveness of static stretching and proprioceptive neuromuscular facilitation stretching in treating delayed onset muscle soreness in calf muscles of runners. Anaesth. pain intensive care 2021;26(1):31-38.
DOI: 10.35975/apic.v26i1.1763
Received: February 20, 2021, Reviewed: November 20, 2021, Accepted: November 22, 2021
Effect of lidocaine infusion compared to dexmedetomidine infusion on proinflammatory cytokines and stress response in pelvi–abdominal cancer surgeries: a randomized clinical trial
Authors: Hassan Mohamed Mahmoud , Saleh Emad Gerges , Abdalla Norma Osama , Radwan Noha Hassan , Abdelghfar Ekramy Mansour 
Published: February 2022

Background & Objectives: Stress response to extensive surgeries in cancer patients results in an imbalance between the pro-inflammatory and anti-inflammatory cytokines, besides activating an inflammatory cascade. We investigated the comparative effects of intravenous infusion of dexmedetomidine and lidocaine on proinflammatory cytokines and the stress reaction.
Methodology: A prospective randomized double blind trial was performed in National Cancer Institute. 54 patients scheduled for pelvi–abdominal cancer surgery under general anesthesia were randomly allocated to three equal groups. Lidocaine group: patients received 1.5 mg/kg loading dose of lidocaine followed by 1.5 mg/kg/h infusion; Dexmedetomidine group: received a loading dose of dexmedetomidine 1 µg/kg followed by infusion of 0.5 µg/kg/h; or Saline group: received 50 ml of normal saline followed by infusion at a rate of 10 ml/h till the end of the surgery. The primary outcome was a postoperative target level of IL–6 after 24 h.
Results: Immediate and 24 h postoperative IL–6 and TNFα were significantly lower in both dexmedetomidine and lidocaine groups compared to the control group (P < 0.001). Dexmedetomidine group had a significantly lower IL–6 and TNFα levels compared to lidocaine group at immediate postoperative and 24 h postoperative period (P < 0.001). Dexmedetomidine and lidocaine groups had a significantly lower lactate and insulin levels compared to the control group immediately postoperatively as well as 24 h postoperatively (P < 0.001). The dexmedetomidine group had a significantly lower lactate levels compared to the lidocaine group immediately postoperatively only. The lidocaine group had lower insulin level than the control group regarding immediate postoperative period only.
Conclusion: Intraoperative infusion of dexmedetomidine or lidocaine, both attenuate the postoperative levels of proinflammatory cytokines and stress response in patients undergoing pelvi–abdominal cancer surgeries.
Clinical trial registration: The study was registered at clinicaltrials.gov (NCT 04148599).
Key words: Lidocaine; Dexmedetomidine; Interleukins; Tumor necrosis factor-α; Stress response; Pelvi–abdominal cancer; Surgery
Abbreviations: TNF - Tumor necrosis factor; IL – Interleukins;
Citation: Hassan MM, Saleh RG, Abdalla NO, Radwan NH, Abdelghfar EM. Effect of lidocaine infusion compared to dexmedetomidine infusion on proinflammatory cytokines and stress response in pelvi–abdominal cancer surgeries: a randomized clinical trial. Anaesth. pain intensive care 2021;26 (1):44-52.
DOI: 10.35975/apic.v26i1.1765
Received: February 15, 2021, Reviewed: December 02, 2021, Accepted: December 05, 2021
Remote monitoring of COVID–19 patients using home pulse oximetry and virtual platform: an observational study
Authors: Akhtaruzzaman AKM , Kamal Md Mostafa , Parveen Monira , Rabbi Marziur , Dhali Rajib , Islam Md Shafiqul , Bhowmick Dilip Kumar 
Published: February 2022

Background: The coronavirus disease (COVID–19) is a global health problem with ever-increasing attributed deaths. Patients with COVID–19 may deteriorate rapidly, and their continuous monitoring is necessary. Monitoring and providing care beyond the traditional face-to-face model is a new chapter in the history of medicine. It consists of remote monitoring and management using virtual platform as a critical component in the ever-changing environment of this deadly pandemic. We evaluated the impact of remote monitoring of the patients at their residences after being infected with SARS-COV-2 virtually.
Methodology: This observational study was conducted among patients with symptoms of COVID–19 attending in the Fever Clinic between January and March 2021. The study was set to continue for the duration of the pandemic. Access to pulse oximeter and virtual platform was given to the enrolled patients. The participants were monitored in a remote monitoring platform at home and during the hospital stay. The primary outcome measures included number of recovery i.e. discharged from remote home monitoring and/or hospital and escalation of management such as hospitalization or transfer to the ICU facilities. Duration of hospital stay, patient experience and satisfaction, and barriers to use the virtual platform were included in the secondary outcome measures.
Results: A total of twenty patients (median age 45 y, male to female ratio 65:35) were included. The median duration of monitoring was 10 days (IQR 8-12 days). Out of twenty patients, 3 (15%) patients needed hospitalization and were recognized in time by the team. The duration of hospital stay was 4 days median (IQR 3-6 days). All patients were discharged from this service safely; no death was reported. Ninety percent of the studied population were satisfied and felt reassured by this remote monitoring service.
Conclusion: Early recognition of deterioration and prompt management through remote monitoring model increases the chances of survival of patients, and reduces the morbidity. Such remote monitoring model can be applied for future outbreaks of pandemics.
Key words: COVID–19; Remote monitoring; Pulse oximetry; Emerging technologies; Virtual platform; Likert’s scale; Satisfaction.
Citation: Akhtaruzzaman AKM, Kamal MM, Parveen M, Rabbi M, Dhali R, Islam MS, Bhowmick DK Remote monitoring of COVID–19 patient using home pulse oximetry and virtual platform: an observational study. Anaesth. pain intensive care 2022;26(1):89-95.
DOI: 10.35975/apic.v26i1.1773
Received: December 14, 2021, Reviewed: January 16, 2022, Accepted: January 22, 2022
Extreme physical exhaustion leading to hypokalemic periodic paralysis- a case report
Authors: Borkotokey Monjuri , Dutta Kaustuv 
Published: February 2022

Sudden onset limb weakness in a young individual requires a thorough evaluation and prompt diagnosis. Delay in treatment awaiting CT scan reports or laboratory investigations can lead to complications. Our case report stresses upon the clinicians to consider hypokalemic periodic paralysis in the differential diagnosis in evaluating such patients. Classical ECG changes and blood gas analysis can effectively diagnose hypokalemia and institute gradual correction of the electrolyte abnormality. In a very rare incident, our patient developed hypokalemia after strenuous exercise.
Key words: Hypokalemic periodic paralysis; Hypokalemia; Flaccid paralysis; Exhaustion
Citation: Borkotokey M, Dutta K. Extreme physical exhaustion leading to hypokalemic periodic paralysis- a case report. Anaesth. pain intensive care 2022;26(1):123-125.
DOI: 10.35975/apic.v26i1.1782
Received: November 30, 2021, Reviewed: December 25, 2021,, Accepted December 27, 2021
The concept of wrapping and its ontological character among the Maya
Authors: Grecco Pacheco Daniel 
Published: February 2022

A textile with its threads, its weft, and warp, for the western ontology, is a simple utilitarian object or a body adornment. This study will discuss the wrapping among the Maya, starting from concepts present in ancient and contemporary Maya thought to identify the ontological character of some ceremonial textiles present in these societies. Based on an approach proposed by the ontological archaeology, I will discuss the conceptual proximity between the terms pix (to wrap, to cover) and pixan (soul, or something that is received from the other world), to think of the wrap as an element of articulation between the two ontological spaces, allowing the presence of beings and entities of the cosmos in Maya cities of the Classic and contemporary periods.
By generating the materialization and performance of these beings, wraps create relational fields that activate these entities temporarily in ordinary space, establishing effective contact with the Maya cosmos. A brief analysis of these Textile Beings present during the Classic Period will be discussed as a case study, in order to consider such a conceptual proposal.
Rock art and rituality in the construction of the Maya person of the Postclassic period at Mensabak Lake, Chiapas
Authors: Lozada Josuhé , Vigliani Silvina , Acosta Guillermo , Pérez Patricia 
Published: February 2022

The notion of person among the Maya has been studied particularly for the Classic and post-contact periods. However, we know little about the Maya person in the Postclassic period. In this paper, our initial assumption is that the Postclassic rock art found in some of the cliffs of Mensabak Lake, Chiapas, conveys elements regarding the notion and construction of the Maya person. In this sense, we analyze the rock paintings and the material culture associated with the cliffs based on the anthropology of the person.
For the Classic Maya, the limits of the person were relatively permeable, something that can be observed in various scenes of Classic art, given the presence of various essences emanating from the bodies of the individuals depicted therein. Permeability, in that sense, is expressed when the person is saturated by substances whose qualities influence the internal composition of the person.
Here we discuss an interpretation of a rock scene from the Postclassic period, where we observe a ritual of construction of the Maya person. In addition, we conducted underwater archaeological surveys and archaeological excavations at the foot of a particular cliff, whose collected materials suggest the presence of a repeated ritual practice, where food was prepared, copal was burned and substances were exchanged with the deities.
Testicular torsion in an elderly patient with cryptorchidism simulating incacerated inguinal hernia
Authors: Roldán Aviña JP , Serrano Borrero I , Merlo Molina S , Pastrana Gallego E , Muñoz Pozo F 
Published: February 2022

Resumen

Introducción: la criptorquidia en pacientes ancianos es extremadamente rara y puede confundirse con una hernia inguinal complicada.

Caso clínico: varón de 96 años que acudió a Urgencias por dolor inguinal izquierdo intenso con una tumoración irreductible a dicho nivel que se catalogó con episodio de incarceración. Tras la exploración física se constató que el hemiescroto izquierdo estaba vacío confirmándose mediante ecografía-doppler que se trataba de una criptorquidia izquierda que había presentado un episodio de torsión testicular.

Discusión: existe poca bibliografía sobre complicaciones agudas de pacientes adultos con criptorquidia. En caso de torsión del testículo no descendido puede confundirse fácilmente con una hernia inguinal incarcerada. En algunos casos se podrá diagnosticar con una ecografía-doppler, aunque en la mayoría de las ocasiones será un hallazgo intraoperatorio.