bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sink, swim, or drift: How social enterprises use supply chain social capital to balance tensions between impact and viability
Authors: Taylor Kelsey M. , Rosca Eugenia 
Published: November 2022

AbstractSocial enterprises seek solutions for some of society's most pressing problems through the development of commercially viable businesses. However, pursuing social impact is often at odds with financial viability, and social enterprises need to engage with a wide range of stakeholders to access tangible and intangible resources to overcome this tension. Although the current literature emphasizes the need for social capital within social enterprises' supply chain relationships, it does not consider the costs associated with the development of such capital. This article examines how social enterprises develop social capital in their supply chain relationships and how this social capital affects their ability to pursue impact and viability. Using data from in‐depth interviews with nine social enterprises, the findings indicate that the roles and positions of beneficiaries in supply chains determine the appropriate forms of social capital needed to sustain simultaneous impact and viability. The empirical insights highlight that structural and relational capital are most valuable within core supply chain relationships, whereas cognitive capital is most beneficial within peripheral relationships aimed at enhancing competitiveness. Further, social enterprises sometimes relinquish power in their supply chain relationships to prioritize impact but develop relational capital to mitigate threats of opportunism. This study advances a contingent view of social capital in cross‐sectoral supply chain relationships and provides valuable implications for managers pursuing impact.
Colonization with multidrug‐resistant organisms is associated with impaired survival of patients with surgically resected cholangiocarcinoma
Authors: Kinzler Maximilian N. , Stehle Angelika , Schulze Falko , Hogardt Michael , Wichelhaus Thomas A. , Kempf Volkhard A. J. , Finkelmeier Fabian , Trojan Jörg , Zeuzem Stefan , Schnitzbauer Andreas A. , Bechstein Wolf O. , Wild Peter J. , Walter Dirk 
Published: November 2022

AbstractBackground & AimsColonization with multidrug‐resistant organisms (MDRO) has been shown to impair survival in patients with various malignancies. Despite the increasing spread of MDRO, its impact on patients with cholangiocarcinoma (CCA) is unclear. Aim of this study was to analyse the impact of MDRO‐colonization on overall prognosis in CCA patients.MethodsAll patients with surgically resected CCA diagnosed between August 2005 and November 2021 at the University Hospital Frankfurt were screened for MDRO. CCA patients with a positive MDRO screening before or within the first 90 days after diagnosis of CCA were defined as colonized. Patients with a negative MDRO screening were defined as non‐colonized.ResultsHundred and sixty nine patients were included. 32% (n = 54) were screened MDRO positive, while 68% (115) were non‐colonized. Median overall survival (OS) for colonized patients was 17.1 months (95% CI = 9–25.2 months) compared to 50 months (95% CI = 37.1–62.8) for MDRO‐negative patients (p ≤ .001). Non‐cancer‐related mortality (p ≤ .001) and infectious‐related death (p ≤ .001) was significantly higher in the MDRO‐colonized group. In multivariate analysis, MDRO colonization (HR = 2.1, 95% CI = 1.4–3.3, p = .001), ECOG 1 (HR = 2.5, 95% CI = 1.6–4, p ≤ .001) and N1 status (HR = 1.7, 95% CI = 1.1–2.6, p = .017) were independent risk factors for OS.ConclusionMDRO‐colonization contributes to poor survival in patients with surgically resected CCA. MDRO surveillance is necessary to optimize clinical management of infections and to potentially reduce mortality in this critical population.
Finite Element Analysis and Transiliac‐Transsacral Screw Fixation for Posterior Pelvic Ring with Sacrum Dysplasia
Authors: Wu Chao , Zeng Baifang , Deng Jiayan , Qin Binwei , Shen Danwei , Wang Xiangyu , Hu Haigang , Huang Li , Liu Xin , Qiu Guigang 
Published: November 2022

ObjectivePosterior pelvic ring sacroiliac screws are preferred by clinicians for their good biomechanical performance. However, there are few studies on mechanical analysis and intraoperative screw insertion of the dysplastic sacrum and sacroiliac screw. This study investigated the biomechanical performance of oblique sacroiliac screws (OSS) in S1 combined with transiliac‐transsacral screws (TTSs) in S2 for pelvic fracture or sacroiliac dislocation with dysplastic sacrum and evaluated the safety of screw placement assisted by the navigation template.MethodsSix models were established, including one OSS fixation in the S2 segment, one transverse sacroiliac screw (TSS) fixation in the S2 segment, one TTS fixation in the S2 segment, one OSS fixation in the S1 and S2 segments, one OSS fixation in the S1 segment and one TSS fixation in the S2 segment, one OSS fixation in the S1 segment and one TTS fixation in the S2 segment. Then, finite element analysis (FEA) was performed. Twelve dysplastic sacrum patients with pelvis fracture or sacroiliac dislocation underwent OSS insertion in the S1 combined with TTS insertion in the S2 under the assistance of the patient‐specific locked navigation template. Grading and Matta scores were evaluated after surgery.ResultsIn the one‐screw fixation group, the vertical displacements of the sacrum surface of S2 OSS, S2 TSS and S2 TTS were 1.23, 1.42, and 1.22 mm, respectively, and the maximum stress of screw were 139.45 MPa, 144.81 MPa, 126.14 MPa, respectively. In the two‐screw fixation group, the vertical displacements of the sacrum surface of the S1 OSS + S2 OSS, S1 OSS + S2 TSS and S1 OSS + S2 TTS were 0.91, 1.06, and 0.75 mm, respectively, and the maximum stress of screw were 149.26 MPa, 167.13 Pa, 136.76 MPa, respectively. Clinically, a total of 12 TTS and OSS were inserted under the assistance of navigation templates, with a surgical time of 55 ± 7.69 min, bleeding of 57.5 ± 18.15 ml and radiation times of 14.5 ± 4.95. One of the TTS and one of the OSS were grade 1, and the other screws were grade 0. The Matta scores of nine patients were excellent, and three patents were good.ConclusionOSS in the S1 combined with TTS in the S2 had the best mechanical stability in six models, and it is safe for screw insertion assisted by the patient‐specific locked navigation template.
Prevalence of AO blood group and level of agreement for AO blood‐typing methods in pet pigs from Louisiana
Authors: Hampton Chiara , Dehghanpir Shannon , Armstrong Chance , Scully Clare , Baker Rose E. , Mitchell Mark 
Published: November 2022

AbstractObjectivesPet pigs are a species of growing medical interest, and evidence‐based practices for blood transfusions are needed. The objectives of this study were to quantify the prevalence of 3 blood group (Bg) phenotypes (“A” and “Aweak” resulting from EAAAAand EAAAO, “0” from EAA00, or “–” from EAA00or SSSalleles) in pet pigs and compare results using a human blood‐typing card (EldonCard), standard saline agglutination (SSA), and polymerase chain reaction (PCR) sequencing.DesignCross‐sectional study.SettingUniversity veterinary teaching hospital.AnimalsNinety‐seven pet pigs from Louisiana.InterventionsBlood was sampled from randomly selected pet pigs of various breeds, anticoagulated with EDTA, and typed using each investigated test according to the manufacturers’ directions or standard laboratory technique. Samples for PCR analysis were stored at –80°C until analysis. Phenotypes were screened via EldonCard. Association between Bg and sex was investigated using chi‐square test, with significance atP < 0.05. Kappa (κ) statistic was used to measure the level of agreement between the 3 tests.Measurements and Main ResultsPot‐bellied pigs represented the majority (84.5%) of this population, with 52 (53.6%) males and 45 (46.4%) females. Genotypic frequencies were 30%, 30%, and 40% for “EAAAA,” “EAAAO,” and “EAA00,” respectively. Based on EldonCard, 38 phenotypes were classified as “A,” 5 as “Aweak,” and 54 as “0” or “–.” Results were identical for Bg, with the 3 tested techniques in 90% (45/50) of samples. Agreement between EldonCard and PCR was almost perfect (49/50 [98%],κ = 0.959;P < 0.001). Agreement between SSA and PCR, and EldonCard and SSA was substantial (46/50 [92%],κ = 0.803,P < 0.001 and 93/97 [95.9%],κ = 0.764,P < 0.001, respectively).ConclusionsThe most common blood type was “0” or “–” (55.7%), followed by “A” (39.2%) and “Aweak” (5.1%). There was strong agreement between EldonCard and PCR testing. EldonCard allowed for rapid and reliable phenotype identification (“A,” “Aweak,” and “0” or “–”) and represents a clinically applicable laboratory method for blood typing in pet pigs.
Impact of donor ferritin testing on iron deficiency prevention and blood availability in France: A cohort simulation study
Authors: Richard Pascale , Fillet Anne‐Marie , Malard Lucile , Leclerc Carole , Chanut Claire , Woimant Geneviève , Jacquot Chantal , Leleu Henri , Morel Pascal , Vimont Alexandre 
Published: November 2022

AbstractBackground and ObjectivesImplementing a ferritin testing policy for whole blood (WB) donors may prevent iron deficiency (ID, ferritin <26 ng/mL) and anaemia, but may induce donation losses. As part of a national prevention plan in France, we aimed to estimate its impact on ID, anaemias and WB donations among donors at high risk of ID.Materials and MethodsA micro‐simulation model was developed to evaluate different scenarios compared to the current situation without ferritin testing as a reference scenario. The following scenarios were simulated: a minimum scenario with a 6‐month deferral for donors with absent iron store (AIS, ferritinemia <15 ng/ml), a main scenario with additional delayed invitations for donors with ferritinemia 15–25 ng/ml and a supplementation scenario with additional iron supplementation for 50% of the donors with AIS.ResultsIn the main scenario, 52,699 WB donations per year were estimated to be lost after 1 year (−8%), falling to 27,687 (−4.7%) after 5 years. IDs and anaemias were reduced by 13.6% and 29.3%, respectively, after 1 year. The supplementation scenario increased the number of prevented IDs and anaemias to 24.1% and 35.4%, respectively, after 1 year, and halved the number of anaemias at 5 years. The latter scenario also had the least impact on the number of donations (−3.2% after 5 years).ConclusionA ferritin testing policy resulting in delayed donations for ID donors is effective in reducing IDs and anaemias, but significantly impacts the number of donations, thereby posing a self‐sufficiency challenge.
The complexities of transfusion reactions: Coexistence of a delayed haemolytic transfusion reaction and post‐transfusion purpura
Authors: Czerwinski Joanna , McCarthy Ana , Herbert Denise , Roxby David , Sobieraj‐Teague Magdalena 
Published: November 2022

AbstractBackground and ObjectivesImmune‐mediated acute or delayed transfusion reactions occur when there is immunological incompatibility between transfused blood products and recipient's antibodies. Acute haemolytic transfusion reactions occur within 24 h and are delayed after 24 h up to 10 days following transfusion, whereas post‐transfusion purpura (PTP) typically occurs 7–10 days post‐transfusion. We present a case of a previously transfused and recently post‐partum female who developed both delayed haemolytic transfusion reaction (DHTR) and PTP.Case ReportA 42‐year‐old woman, G2P1, with non‐alcoholic liver disease, portal hypertension and previous transfusion history with allogeneic anti‐E, developed a severe DHTR and PTP following a complicated post‐partum course and multiple transfusions. The antenatal and initial post‐partum pre‐transfusion antibody screens were negative. Subsequently five red cell antibodies, including anti‐c, anti‐Fya, anti‐Jkb and anti‐S and the reappearance of anti‐E were, however, identified during follow‐up investigations along with the anti‐platelet antibody HPA‐3a and human leukocyte antigen class I antibodies. Anti‐E, anti‐Jkb and anti‐S were eluted from the circulating red blood cells.ConclusionTo our knowledge, there have been only two other case reports of DHTR and PTP occurring in the same patient.
Blood component ratios in children with non‐traumatic life‐threatening bleeding
Authors: Marshall Callie , Josephson Cassandra D. , Leonard Julie C. , Wisniewski Stephen R. , Leeper Christine M. , Luther James F. ,   the MATIC Investigators and BloodNet, Spinella Philip C. 
Published: November 2022

AbstractBackground and ObjectivesIn paediatric trauma patients, there are limited prospective data regarding blood components and mortality, with some literature suggesting decreased mortality with high ratios of plasma and platelets to red blood cells (RBCs) in massive transfusions; however, most paediatric massive transfusions occur for non‐traumatic aetiologies and few studies assess blood product ratios in these children. This study's objective was to evaluate whether high blood product ratios or low deficits conferred a survival benefit in children with non‐traumatic life‐threatening bleeding.Materials and MethodsThis is a secondary analysis of the five‐year, multicentre, prospective, observational massive transfusion epidemiology and outcomes in children study of children with life‐threatening bleeding from US, Canadian and Italian medical centres. Primary interventions were plasma:RBC and platelets:RBC (high ratio ≥1:2 ml/kg) and plasma and platelet deficits. The primary outcome was mortality at 6 h, 24 h and 28 days. Multivariate logistic regression models were used to determine independent associations with mortality.ResultsA total of 222 children were included from 24 medical centres: 145 children (median [interquartile range] age 2.1 years [0.3–11.8]) with operative bleeding and 77 (8.0 years [1.2–14.7]) with medical bleeding. In adjusted analyses, neither blood product ratios nor deficits were associated with mortality at 6 h, 24 h or 28 days.ConclusionThis paper addresses a lack of prospective data in children regarding optimal empiric massive transfusion strategies in non‐traumatic massive haemorrhage and in finding no decrease in mortality with high plasma or platelet to RBC ratios or lower deficits supports an exploratory analysis for mortality.
Diabetes self-management education for older adults in Western countries: a scoping review protocol
Authors: Camargo-Plazas Pilar , Robertson Madison , Paré Geneviève C. , Costa Idevania G. , Alvarado Beatriz , Ross-White Amanda , Duhn Lenora 
Published: November 2022

Objective:
This scoping review will map the available evidence on diabetes self-management education programs for older adults in Western countries.

Introduction:
Self-management and education are crucial for controlling diabetes and its associated complications. The successful uptake of diabetes self-management education programs is not straightforward, and little is known about diabetes programs for older adults. Within this context, a broad overview of diabetes self-management education for older adults, considering all types of related evidence, is needed.

Inclusion criteria:
All studies in English concerning diabetes self-management education for older adults (aged 65 years and older) living with type 1 or 2 diabetes will be included. This review will not be specific to gender, sex, ethnicity, frailty, or other demographic variables. The review will be restricted to Western countries (North America, Western and Northern Europe, and Australasia), where approaches to diabetes self-management education will be similar. Studies including older adults with or without diabetes will not be considered unless they provide separate analyses for the 2 cohorts.

Methods:
This scoping review will follow the JBI methodology for scoping reviews. We will conduct searches of electronic databases, including CINAHL, MEDLINE, and PubMed, from January 1, 2000, to the present to capture eligible articles. The review will consider all study designs, including quantitative, qualitative, mixed methods designs, as well as text and opinion papers, and systematic reviews that meet the inclusion criteria. After duplicates are removed, titles and abstracts will be screened independently by 2 reviewers, and the full texts will be reviewed. The screening criteria and data extraction protocol will be pilot-tested by the research team. The results will be summarized in tables accompanied by narrative text.
Evolution of a physician wellness, engagement and excellence strategy: lessons learnt in a mental health setting
Authors: Wilkie Treena , Tajirian Tania , Thakur Anupam , Mistry Smit , Islam Faisal , Stergiopoulos Vicky 
Published: November 2022

ObjectiveThis study aims to evaluate the impact of several organisational initiatives implemented as part of a physician engagement, wellness and excellence strategy at a large mental health hospital. Interventions that were examined include: communities of practice, peer support programme, mentorship programme and leadership and management programme for physicians.MethodsA cross-sectional study, guided by the Reach, Effectiveness/Efficacy, Adoption, Implementation and Maintenance evaluation framework, was conducted with physicians at a large academic mental health hospital in Toronto, Canada. Physicians were invited to complete an online survey in April 2021, which composed of questions on the awareness, use and perceived impact of the organisational wellness initiatives and the two-item Maslach Burnout Inventory tool. The survey was analysed using descriptive statistics and a thematic analysis.Results103 survey responses (40.9% response rate) were gathered from physicians, with 39.8% of respondents reporting experiences of burn-out. Overall, there was variable reach and suboptimal use of the organisational interventions reported by physicians. Themes emerging from open-ended questions included the importance of addressing: workload and resource related factors; leadership and culture related factors; and factors related to the electronic medical record and virtual care.ConclusionsOrganisational strategies to address physician burn-out and support physician wellness require repeated evaluation of the impact and relevance of initiatives with physicians, taking into account organisational culture, external variables, emerging barriers to access and participation, and physician needs and interest over time. These findings will be embedded as part of ongoing review of our organisational framework to guide changes to our physician engagement, wellness and excellence strategy.
Characteristics of rich flame blowout during the condition transition of a scramjet
Authors: Jia Dongpeng , Pan Yu , Liu Chaoyang , Wang Ning , Wang Taiyu 
Published: November 2022

The global equivalence ratio (ER1) will change drastically when scramjets carry out the mission of condition transition. The blowout characteristics of partially premixed flame in a fuel-rich condition are investigated experimentally in a cavity-stabilized scramjet combustor. The total pressure, total temperature and Mach number at the combustor entrance are 1.6 MPa, 1486 K and 2.52, which can simulate the flight condition of Mach 5.5 at 25 km altitude. When the final ER1 is relatively small, the range and light intensity of flame increase first and then almost keep constant. The cavity-stabilized flame can be switched from cavity shear layer to jet-wake. Once the final ER1 exceeds a critical value, the rich flame blowout phenomena will appear suddenly. During the blowout process, the flame in the cavity is blown out first and then the flame downstream extinguishes completely along the rear-wall. The intensity of combustion at the flame front is more vigorous with a higher ER1 at the initial combustion state, which is conductive to burn more fuel mixed in the incoming flow. When the initial flowfields are more vigorous, the stabilized flame can be shifted to a stronger combustion state under a higher ER1.
Nonhuman Animals as Symbols in the #BlackLivesMatter Protests of 2020
Authors: Warda Tiamat , Aiello Thomas , Hill Kristine 
Published: November 2022

Abstract
Racial uprisings often include animalized commentary and symbolic use of nonhuman animal bodies. This paper highlights some of the nonhuman animal bodies observed during the #BlackLivesMatter protests within the United States in 2020 – specifically, the use of pig, horse, and dog bodies during street protests. Displays of pigs carry with them a racially rife past in the United States. This history harmed protesters during #BlackLivesMatter protests, being described as suffering “like animals,” and the use of “pig” as an epithet for the police is explored. For the Black Cowboys who joined the protests on horseback, the physical presence of their horses amplified their message, symbolized a shift in their freedom, and positioned them eye-to-eye with the mounted police officers. The use of dog bodies within politics, how they amplified political messages as “sign-carrying vehicles,” and the dangers for them and others in protests are addressed.
Host genetic control on rumen microbiota and its impact on dairy traits in sheep
Authors: Martinez Boggio Guillermo , Meynadier Annabelle , Buitenhuis Albert Johannes , Marie-Etancelin Christel 
Published: November 2022

Abstract
Background
Milk yield and fine composition in sheep depend on the volatile and long-chain fatty acids, microbial proteins, vitamins produced through feedstuff digestion by the rumen microbiota. In cattle, the host genome has been shown to have a low to moderate genetic control on rumen microbiota abundance but a high control on dairy traits with heritabilities higher than 0.30. There is little information on the genetic correlations and quantitative trait loci (QTL) that simultaneously affect rumen microbiota abundance and dairy traits in ruminants, especially in sheep. Thus, our aim was to quantify the effect of the host genetics on rumen bacterial abundance and the genetic correlations between rumen bacterial abundance and several dairy traits, and to identify QTL that are associated with both rumen bacterial abundance and milk traits.

Results
Our results in Lacaune sheep show that the heritability of rumen bacterial abundance ranges from 0 to 0.29 and that the heritability of 306 operational taxonomic units (OTU) is significantly different from 0. Of these 306 OTU, 96 that belong mainly to the Prevotellaceae, Lachnospiraceae and Ruminococcaceae bacterial families show strong genetic correlations with milk fatty acids and proteins (absolute values ranging from 0.33 to 0.99). Genome-wide association studies revealed a QTL for alpha-lactalbumin concentration in milk on Ovis aries chromosome (OAR) 11, and six QTL for rumen bacterial abundances i.e., for two OTU belonging to the genera Prevotella (OAR3 and 5), Rikeneleaceae_RC9_gut_group (OAR5), Ruminococcus (OAR5), an unknown genus of order Clostridia UCG-014 (OAR10), and CAG-352 (OAR11). None of these detected regions are simultaneously associated with rumen bacterial abundance and dairy traits, but the bacterial families Prevotellaceae, Lachnospiraceae and F082 show colocalized signals on OAR3, 5, 15 and 26.

Conclusions
In Lacaune dairy sheep, rumen microbiota abundance is partially controlled by the host genetics and is poorly genetically linked with milk protein and fatty acid compositions, and three main bacterial families, Prevotellaceae, Lachnospiraceae and F082, show specific associations with OAR3, 5, 15 and 26.