bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differentiating Associations of Glycemic Traits with Atherosclerotic and Thrombotic Outcomes: Mendelian Randomization Investigation
Authors: Yuan Shuai , Mason Amy M. , Burgess Stephen , Larsson Susanna C. 
Published: May 2022

<p> We conducted a Mendelian randomization analysis to differentiate associations of four glycemic indicators with a broad range of atherosclerotic and thrombotic diseases. Independent genetic variants associated with fasting glucose (FG), 2-h glucose after an oral glucose challenge (2hGlu), fasting insulin (FI), and glycated hemoglobin (HbA1c) at the genome-wide significance threshold were used as instrumental variables. Summary-level data for 12 atherosclerotic and 4 thrombotic outcomes were obtained from large genetic consortia and the FinnGen and UK Biobank studies. Higher genetically-predicted glycemic traits were consistently associated with an increased risk of coronary atherosclerosis related diseases and symptoms. Genetically-predicted glycemic traits except HbA1c showed positive associations with peripheral artery disease risk. Genetically-predicted FI levels were positively associated with risk of ischemic stroke and chronic kidney disease. Genetically-predicted FG and 2hGlu were positively associated with the risk of large artery stroke. Genetically-predicted 2hGlu levels showed positive associations with the risk of small vessel stroke. Higher levels of genetically-predicted glycemic traits were not associated with increased risk of thrombotic outcomes. Most associations for genetically-predicted levels of 2hGlu and FI remained after adjusting for other glycemic traits. Increased glycemic status appears to increase risks of coronary and peripheral artery atherosclerosis, but not thrombosis. </p>
Neglecting Quality Assurance Practices in Colleges of Education in Ghana is too Expensive to Attempt: Analysis of Sociological Variables
Authors: Lemaire Margaret B. , Adams Francis H. , Adibi Maria-Goretti D. 
Published: May 2022

This study sought to find out the state of the structures of quality assurance practices in Colleges of Education in Ghana. It specifically explored the sociological variables and the challenges associated with ensuring quality assurance practices in the management of the Colleges of Education. The design for the research was non experimental descriptive survey and data were gathered through the use of questionnaires. There were 3 sets of questionnaires one for each group namely principals, tutors and students of five colleges of education. Each of the questionnaires were validated and their reliability tested with a Cronbach’s co efficient alpha of 0.829 for the students and 0.914 for the tutors. The results were an indication of good reliability estimate. In all, 5 principals, 180 tutors and 1,153 students were given the questionnaires. Findings from the study suggested that students admitted to the Colleges enter with poor grades. The libraries are also not well-equipped for students and tutors to support quality teaching and learning. The study also found out that the professional experience of tutors in the Colleges was excellent. Based on the findings, it is recommended that, firstly, admissions should be based on the Ghana Tertiary Education (GTEC) requirements for tertiary institutions. Secondly, principals should be encouraged to attend institutional management courses to improve upon their management styles. Thirdly, adequate financial resources should be allocated to the Library so that current books, journals and reference books can be purchased to improve teaching and learning. Fourthly, quality assurance units should be established in the Colleges to ensure quality.
Eventos adversos em unidades de saúde do estado da Bahia, antes e durante a COVID-19
Authors: Oliveira Larayne Gallo Farias de , Boere Vanner , Silva Ita de Oliveira e 
Published: May 2022

Os eventos adversos (EA) na assistência à saúde são incidentes que resultam em dano evitável ao paciente. A COVID-19 alterou rotinas em hospitais, podendo se refletir nos índices de EA. Com dados da vigilância sanitária (Notivisa), comparou-se a ocorrência mensal de EA antes e durante da pandemia em instituições de saúde do estado da Bahia, Brasil. Os EA ocorreram significativamente mais (P=0,03) durante a COVID-19 comparado à média mensal dos anos anteriores. Três fatos parecem ter contribuído para o aumento dos EA: a sobrecarga para o atendimento ao COVID-19; má gestão dos serviços de saúde; e informações conflitantes sobre protocolos de procedimentos preventivos e terapêuticos. Sugere-se que houve um aumento do custo econômico, do sofrimento de pacientes e das equipes de saúde durante a pandemia devido à maior frequência de EA.
Descritores: Anvisa, COVID-19, Segurança do Paciente, Vigilância em Saúde.

Adverse events in health facilities in the state of Bahia, before and during COVID-19
Abstract: Adverse events (AE) in health care are incidents that result in preventable harm to the patient. COVID-19 changed routines in hospitals, which may be reflected in AE rates. Using data from health surveillance (Notivisa), the monthly occurrence of AE before and during the pandemic was compared in health institutions in the state of Bahia, Brazil. AEs occurred significantly more (P=0.03) during COVID-19 compared to the monthly average of previous years. Three facts seem to have contributed to the increase in AE: the burden of attending to COVID-19; poor management of health services; and conflicting information on protocols for preventive and therapeutic procedures. It is suggested that there was an increase in the economic cost, suffering of patients and health teams during the pandemic due to the higher frequency of AE.
Descriptors: Anvisa, COVID-19, Patient Safety, Health Surveillance.

Eventos adversos en establecimientos de salud del estado de Bahía, antes y durante el COVID-19
Resumen: Los eventos adversos (EA) en el cuidado de la salud son incidentes que resultan en daños prevenibles para el paciente. COVID-19 cambió las rutinas en los hospitales, lo que puede reflejarse en las tasas de EA. Utilizando datos de vigilancia de la salud (Notivisa), se comparó la ocurrencia mensual de EA antes y durante la pandemia en instituciones de salud del estado de Bahía, Brasil. Los EA ocurrieron significativamente más (P = 0.03) durante COVID-19 en comparación con el promedio mensual de años anteriores. Tres hechos parecen haber contribuido al aumento de EA: la carga de atender COVID-19; mala gestión de los servicios de salud; e información contradictoria sobre protocolos de procedimientos preventivos y terapéuticos. Se sugiere que hubo un aumento en el costo económico, sufrimiento de los pacientes y equipos de salud durante la pandemia debido a la mayor frecuencia de EA.
Descriptores: Anvisa, COVID-19, Seguridad del Paciente, Vigilancia de la Salud.
Effect of high hydrostatic pressure on the in vitro development and molecular quality of transgenic rabbit embryos derived from nano-transfected zygotes
Authors: Dzięgiel Natalia , Jura Jacek , Samiec Marcin 
Published: May 2022

Abstract
The aim of this study was to evaluate the effect of high hydrostatic pressure (HHP) on the in vitro developmental abilities of nano-transfected rabbit zygotes, their transfection efficiency, and the molecular quality of the blastocysts generated. This quality was assessed by estimating the quantitative profiles of Oct4, Casp7, and Bcl2 mRNA transcripts. The nano-transfection efficiencies of zygotes that had been pre-treated with either 20 MPa or 40 MPa of HHP (13.5% and 13.7%, respectively) were insignificantly lower than those found in zygotes not exposed to HHP prior to their nano-transfection (20.1%; P≥0.05). Moreover, applying HHP treatment with the parameters of 20 MPa and 40 MPa followed by the nano-transfection of zygotes brought about an insignificant decrease in the rates of embryos at the blastocyst stage (30.4% and 23.0%, respectively) as compared to the control group of nano-transfected zygotes (40.4%; P≥0.05). Furthermore, analyzing the transcriptional activity of Oct4, Bcl2, and Casp7 genes revealed that HHP enhances the relative abundance (RA) of all mRNA transcripts in blastocysts derived from non-transfected rabbit zygotes. In turn, the augmented RAs found in the pro-apoptotic Casp7 and anti-apoptotic Bcl-2 transcripts confirmed the onset and progression of programmed cell death in blastocysts developed from nano-transfected zygotes that had undergone HHP pre-treatment. The conceptualization based not only on a novel nano-transfection approach used to genetically modify in vivo-fertilized rabbit zygotes but also on their HHP pre-treatment is elaborated here for the first time, with an emphasis on further investigations aimed at producing transgenic rabbit and other mammalian species embryos by somatic cell cloning.
Pharmacotherapeutic potential of astaxanthin: Human and animal targeting roles – A review
Authors: El Basuini Mohammed F. , El-Bilawy Emad H. , Kari Zulhisyam Abdul , Raza Sayed Haidar Abbas , Tapingkae Wanaporn , Van Doan Hien , Dawood Mahmoud A.O. 
Published: May 2022

Abstract
The recent pandemic stress and the impacts of climatic changes on humans’ and animals’ health status and well-being resulted in severe drawbacks. Initially, stress-induced oxidation resulting from the generation of free radicals led to the impairment of cellular function and a high possibility of attack with infection. Astaxanthin is a bioactive material derived from fish, crustaceans, and algae with high antioxidative potential. Astaxanthin is a lipid-soluble carotenoid that can easily cross through the cellular membrane layers to catch the reactive oxygen metabolites. Astaxanthin also has pigmentation properties making it suitable for pharmaceutical, cosmetic, nutraceutical, agriculture, and aquaculture sectors. Recently, astaxanthin is suggested as a natural scavenger for free radicals induced by COVID-19. Besides, using astaxanthin as antioxidative and immunostimulant agents is well-reported in several clinical studies. The output of these investigations should be simplified and presented to the scientific community to utilize the available information and fill the gap of knowledge. Also, it is necessary to update the researchers with the recent recommendations of applying astaxanthin in vivo and in vitro to help in proposing new horizons for engaging natural antioxidative agents to protect human and animal health. Herein, this review article tackled the nature, sources, potential roles, applicable sides, and availability of astaxanthin to fortify the scientific community with the required knowledge for further research efforts.
The effects of dietary stachyose as prebiotic on immunity and antioxidant related genes’ expression and lipid metabolism in zebrafish (Danio rerio)
Authors: Aski Hesamaddin Shirzad , Hoseinifar Seyed Hossein , Bayani Mahsan , Reeisi Mojtaba , Khalili Mohsen , El-Haroun Ehab , Van Doan Hien 
Published: May 2022

Abstract
An 8-week feeding trial was conducted to examine the efficacy of stachyose as a prebiotic on immune parameters, antioxidant-/immune-related genes’ expression, and lipid metabolism of zebrafish. Three hundred zebrafish (0.45 ± 0.08 g) were fed four diets containing different stachyose levels at 0, 1, 2 and 4 g kg−1, respectively. After eight weeks of the feeding trial, immunity, antioxidant defence and lipid metabolism were tested. It was observed that the addition of stachyose to the diet induced no significant influence (P>0.05) in SOD, GPX, and CAT, gene’s expression, compared to the control diet. The inclusion of stachyose resulted in no significant changes in immune gene expression (Lyz, IL-1, IL-6, and TNF) in zebrafish (P>0.05) compared to the control diet. Total cholesterol, triglyceride and LDL (low-density lipoprotein) significantly (P<0.05) decreased with the addition of 2 and 4 g kg−1 stachyose, while fish fed the control diet and 1 g.kg−1 recorded the highest significant value of LDL (P<0.05). Fish fed diet, either control diet or diet supplemented with 0.5 g kg−1 stachyose, recorded the lowest HDL value (P<0.05) compared to other treatments. In conclusion, stachyose can be potentially used as a feed additive to modulate lipid metabolism. However, this prebiotic did not benefit immune parameters and antioxidant defence.
The effects of coriander (Coriandrum sativum) seeds on the growth performance, growth hormone, antibacterial capacity, and immune response of European sea bass (Dicentrarchus labrax)
Authors: Ashry Ahmed M. , Habiba Mahmoud M. , Desouky Mohammed G. , El-Zayat Ahmed M. , Moonmanee Tossapol , Van Doan Hien , Dawood Mahmoud A.O. 
Published: May 2022

Abstract
Coriander seeds are among the functional herbal supplements, but their effects on aquatic animals are still lacking. Herein we evaluated the effects of coriander seeds on the growth performance, growth hormone, antibacterial capacity, and immune response of European sea bass (Dicentrarchus labrax). Fish with initial mean weights of 5.08 ± 0.12 g/fish were allocated in four groups (in triplicate) and fed dietary coriander at 0, 5, 10, and 20 g/kg for 150 days. The growth performance, feed utilization, and survival rate of fish-fed dietary coriander meaningfully increased (P<0.05). The protein efficiency ratio gradually increased (P<0.05) in fish-fed coriander seeds compared with the control. On the other hand, the feed conversion ratio was gradually decreased (P<0.05) in fish-fed coriander seeds comparing with the control. The survival rate was markedly increased (P<0.05) in European sea bass fed dietary coriander regardless of the inclusion level. Further, no differences were seen among fish fed varying levels of coriander (P<0.05). The level of blood growth hormone was markedly higher (P<0.05) in European sea bass fed dietary coriander at 20 g/kg than fish-fed 0 and 5 g/kg. The abundance of intestinal Vibrio spp. and fecal coliform were obviously lower (P<0.05) in fish fed 10 and 20 g/kg than fish fed the coriander-free diet. Further, fish fed 20 g/kg had lower (P<0.05) Vibrio spp. and Faecal Coliform counts than fish fed 10 g/kg. Fish fed dietary coriander had significantly higher (P<0.05) hematocrit, hemoglobin, red blood cells (RBCs), and white blood cells (WBCs) than fish fed the control. The lysozyme and phagocytic activities were meaningfully increased (P<0.05) in fish fed 10 and 20 g/kg compared with fish fed 0 and 5 g/kg of dietary coriander. In conclusion, dietary coriander could be included in the diets at 10–20 g/kg to improve the growth performance, growth hormone, feed utilization, and immune response of European sea bass.
Psicología, psicoanálisis y sentido. Relaciones conceptuales entre Michel Foucault y Georges Politzer
Authors: Abeijón Matías 
Published: May 2022

La investigación que se presenta tiene como objetivo el análisis teórico e histórico de los cruces entre psicología, psicoanálisis y filosofía en artículo temprano de Michel Foucault, “La psychologie de 1850 à 1950”. Se pretende realizar un análisis teórico de los argumentos en los que se apoyan una serie de postulados valorativos y críticas a la psicología y al psicoanálisis. A su vez, estos argumentos derivan del análisis del libro de George Politzer, Critique des fondements de la psychologie. Se sostiene que Michel Foucault, a partir de los trabajos de Politzer, elabora el concepto de sentido para dar fundamento al psicoanálisis y a las psicologías contemporáneas.
MENANAMKAN EMPATI, MENUMBUHKAN SELEKSI: KIPRAH GEFNIWATI DALAM MANAJEMEN SANGGAR SENI ALANG BANGKEH PADANGPANJANG
Authors: Ulfa Mutia , Risnawati Risnawati , Gusti Adriana 
Published: May 2022

This article discusses the role of the late Gefniwati as a coach at the Alang Bangkeh Studio in Padangpanjang City, from a management point of view. Gefniwati founded Sanggar Alang Bangkeh to be able to gather creativity, talent and interest among the younger generation and direct their energy to positive values. Sanggar Alang Bangkeh has two program plans, namely short-term and long-term. Gefniwati developed the management of Sanggar Alang Bangkeh in four ways, namely planning, organizing, directing, and supervising. The results can be seen from the frequent appearances of Sanggar Alang Bangkeh at important events both within and outside the region. In addition, the collaboration with the Padangpanjang City government has made this studio more developed and has a place in the hearts of the people. The results showed that Gefniwati succeeded in developing good management in managing the Alang Bangkeh Studio, so that the performances presented were always in accordance with the wishes or demands of the community. The key to success lies in the values that have been aspired from the start, namely instilling a sense of empathy for traditional arts, and fostering the ability to select from foreign cultural influences.AbstrakArtikel ini membahas tentang kiprah Mendiang Gefniwatiselaku pembina pada Sanggar Alang Bangkeh di Kota Padangpanjang, dari sudut pandang manajemen. Gefniwati mendirikan Sanggar Alang Bangkeh untuk dapat menghimpun kreatifitas, bakat dan minat kalangan generasi muda dan mengarahkan energi mereka pada nilai-nilai positif. Sanggar Alang Bangkeh memiliki dua perencanaan program yaitu jangkapendek dan jangkapanjang. Gefniwati mengembangkan manajemen Sanggar Alang Bangkeh melalui empat cara, yakni Perencanaan, Pengorganisasian, Pengarahan, dan Pengawasan. Hasilnya dapat dilihat dari seringnya Sanggar Alang Bangkeh tampil pada event-event penting baik dalam maupun luar daerah. Selain itu kerjasama yang dijalankan dengan pemerintah Kota Padangpanjang, menjadikan sanggar ini semakin berkembang dan mendapat tempat dihati masyarakat. Hasil penelitian menunjukkan bahwa Gefniwati berhasil dalam mengembangkan manajemen yang baik dalam mengelola Sanggar Alang Bangkeh, sehingga pertunjukan yang disuguhkan selalu sesuai dengan keinginan atau tuntutan masyarakat. Kunci kesuksesan itu terletak pada nilai yang dicita-citakan sejak awal, yakni menanamkan rasa empati kepada kesenian tradisional, dan menumbuhkan kemampuan seleksi pada pengaruh budaya asing.Kata Kunci: Gefniwati; sanggar seni; Alang Bangkeh; manajemen seni
Influência do SARS-COV-2 no sistema reprodutor humano
Authors: Rodrigues Maria Eduarda da Silva , Dantas Bruna Braga 
Published: May 2022

<p>O SARS-CoV-2 é o agente causador da pandemia do COVID-19, sendo considerado um vírus respiratório, pois possui um tropismo pelo pulmão, entretanto, sua presença foi evidenciada em diversos órgãos, incluindo o trato reproduto. Outros vírus também já foram identificados no sistema reprodutor humano, como exemplo o vírus da caxumba, da imunodeficiência humana, papilomavírus humano, entre outros. A Enzima Conversora de Angiotensina 2 (ECA2) é utilizada pelo SARS-CoV-2 para adentrar as células e, além dos pulmões, ela está presente em outros órgãos como os testículos, ovários, oócitos, vagina, útero e placenta, sugerindo que esses órgãos também podem sofrer infecção pelo SARS-CoV-2. Achados patológicos foram identificados em testículos de homens que foram a óbito por COVID-19, além de identificada epididimite em pacientes internados com COVID-19. Sabe-se que as mulheres alcançam depuração viral primeiro que os homens, porém, durante a gestação, o SAR-CoV-2 infecta a placenta. Esse agente etiológico já foi encontrado no líquido amniótico e no neonato. Devido a sua fisiopatologia, ele potencializa o risco de trombose nas gestantes, fator que pode levar a partos prematuros e comprometimento da gestação. Apesar da temática ser ainda muito recente, devido as condições vivenciadas estarem enquadradas numa crise de saúde pública global, foi possível perceber que existe relação da infecção com SARS-CoV-2 e o trato reprodutor humano. </p><p><strong>Palavras chave</strong>: Coronavírus, Covid-19, doença infecciosa, saúde reprodutiva.</p>
Does Gender Matter?
Authors: McPhillips Kathleen , McEwan Tracy , Death Jodi , Richards Kelly 
Published: May 2022

Abstract
Sociological and historical research into sexual violence against children has reported consistently that it is girls who have most often been the subject of sexual, psychological and physical violence in both familial and institutional settings in modernity. However, more recently, public inquiries have provided evidence that during the 20th century, boys were much more likely to be abused in particular kinds of religious settings. This has been substantiated in findings from inquiries in Australia, Ireland, the UK and the USA. This reverses the trend of child sexual abuse (CSA) demonstrated in family and community environments, where girls are more likely to be abused, although perpetrators are much more likely to be men across all settings (Dowling, Boxall, et al. 2021). The question of gender in relation to the experience and management of CSA therefore requires further examination. In this article we investigate whether gender is a specific dimension of CSA in religious institutions, and specifically the Roman Catholic Church, by two methods. We begin by firstly examining the literature that addresses gender representation, religion and CSA in relation to three central evidence-based indicators: prevalence, disclosure and trauma impacts. Secondly, we link this discussion to a case study of the Catholic Church in Australia, where we identify specific patterns of gendered child violence and we ask the question: are such gendered forms of violence related to Catholic socialisation processes and if so by which specific mechanisms does Catholic culture produce the conditions that facilitate the sexual abuse of children? This article will explore these questions by looking at the ways CSA in Catholic institutions are gendered and how this produced particular forms of knowledge and truth. We argue that gender is a central organising principle in Catholic bureaucracy, culture and theology. The analysis identifies five central factors underpinning the reproduction of a discourse of power and knowledge normalizing gendered patterns of CSA and addresses a gap in current research by addressing gender representation as the central factor in the prevalence, disclosure and trauma of religiously based CSA.
Ultrasound-guided bilateral erector spinae plane nerve blocks: a novel application for the management of acute postoperative pain in awake spine surgery. Illustrative case
Authors: Braxton Ernest E. , Brena Kyle R. , Spears Holley , Conrad Emerson , Heinze Jared D. 
Published: May 2022

BACKGROUND
Postoperative pain management is a limiting factor for early ambulation and discharge following spine fusion surgery. Awake spinal surgery, when combined with minimally invasive transforaminal lumbar interbody fusion, is associated with enhanced recovery in well-selected patients. Some neurosurgeons have recently aimed to further improve outcomes by utilizing erector spinae plane block catheters, allowing for a continuous infusion of local anesthetic to improve the management of acute postoperative pain following minimally invasive transforaminal lumbar interbody fusion.

OBSERVATIONS
A patient who underwent a minimally invasive transforaminal lumbar interbody fusion with perioperatively placed erector spinae plane catheters at the T12 level ambulated 30 minutes after surgery and was discharged the same day (length of stay, 4.6 hours). The total amount of narcotics administered during the hospital stay was 127.5 morphine milligram equivalents.

LESSONS
The placement of bilateral erector spine plane nerve block catheters at the T12 level with an ambulatory infusion pump may help to improve acute postoperative pain management for patients undergoing lumbar spinal fusion.