bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incorporating non-uniformity and non-linearity of hydrologic and catchment characteristics in rainfall–runoff modeling using conceptual, data-driven, and hybrid techniques
Authors: Vidyarthi Vikas Kumar , Jain Ashu 
Published: February 2022

Abstract
The rainfall–runoff (RR) process in a catchment is non-uniform, complex, dynamic, and non-linear in nature. Although a number of advanced conceptual and data-driven techniques have been proposed in the past, the accurate estimation of daily runoff still remains a challenging task. A majority of conceptual models proposed so far suffer from the assumptions of linearity during their modeling. In this paper, novel hybrid approaches are proposed that are capable of exploiting the strength of both conceptual and data-driven techniques in RR modeling. A conceptual technique is first used to generate sub-basins’ runoff hydrographs in upstream reaches and then data-driven techniques are employed for routing them to the outlet of the catchment. The hybrid models’ performances are compared with standalone conceptual and data-driven models by employing the daily rainfall, runoff, and temperature data derived from the Kentucky River basin, USA. The results show that the proposed hybrid models, which do not assume the RR process to be a linear process to simulate the flow, outperform their individual counterparts. It is concluded that in order to achieve improved accuracy in RR modeling, the real-life process needs to be represented as accurately as possible in the modeling effort rather than making simplified assumptions.
Occurrence of pathogenic microorganisms in small drinking-water systems in Costa Rica
Authors: Barrantes Kenia , Chacón Luz , Morales Eric , Rivera-Montero Luis , Pino Macario , Jiménez Alejandra Gamboa , Mora Diana Campos , Jiménez Pablo Salas , Silva Basilio , Romero-Esquivel Luis G. 
Published: February 2022

AbstractThis study describes the quality of drinking water sampled over 2 years (2018 and 2019) from 20 ASADAS (Spanish acronym for Administrative Associations for Water and Sewer Systems) in Costa Rica. The analysis included Rotavirus (RV), somatic coliphages, fecal coliforms, and Escherichia coli. The ASADAS were categorized into three regions as temperate rainy (region 1), tropical rainy (region 2), and tropical rainy and dry (region 3) according to biogeographic classification. The concentrations of fecal coliforms and E. coli were higher in samples from surface water sources from the ASADAS in region 3 compared to regions 1 and 2. RV-positive samples (24/296) were detected in drinking-water samples from regions 2 and 3 during dry and transition seasons, with higher concentrations more frequently in the dry season. In addition, somatic coliphages were detected in samples from the three regions, with higher concentrations in region 2. Furthermore, a statistically significant relationship was found between somatic coliphages and diarrheal cases, classified as outbreaks or alerts in the region. Thus, the results confirmed that somatic coliphages are a good indicator of the presence of diarrhea cases in a specific region.
Performance evaluation of an HDH desalination system using direct contact packed towers: experimental and mathematical modeling study
Authors: Zarei Taleb , Miroliaei Mohammad Reza 
Published: February 2022

Abstract
Humidification–dehumidification desalination (HDH) is one of the suitable methods for desalination of saline and brackish water in a small scale. In this research, an HDH desalination method with a direct contact dehumidifier has been analyzed theoretically and experimentally. The setup consists of two similar packing towers for humidification and dehumidification, 10 inches in diameter, which are filled up to 1 m with Rushing packing. In this new HDH configuration, seawater and freshwater recirculation has been used in humidifier and dehumidifier sections, respectively. A steady-state mathematical model based on the mass and energy equations for each system component is presented. The effect of various input parameters on the freshwater production, gain output ratio (GOR) and specific energy consumption has been investigated. The results revealed that the inlet seawater and air temperature to the humidification tower had the highest and the lowest effect on the produced freshwater, respectively. Also, the maximum value of the GOR is 3.3, which is obtained in the equilibrium condition of the dehumidifier. The experiments show that the freshwater production of the proposed HDH device is 300 L/day, which can provide water for the domestic consumption of a small family.
Development and performance of a dynamic membrane for anaerobic wastewater treatment – an analysis with different mesh pore sizes and configurations
Authors: Fonseca Paula Rafaela Silva , Mora Erick Javier Centeno , Batista Isabela Ferreira , Chernicharo Carlos Augusto de Lemos 
Published: February 2022

Abstract
Recent studies have focused on proposing materials with larger pores and lower cost to replace conventional membranes. This study aims to investigate the performance of an anaerobic dynamic membrane bioreactor (AnDMBR) at pilot scale, acting as a post-treatment for an Upflow Anaerobic Sludge Blanket (UASB) reactor treating sewage, for the removal of complementary organic matter, focusing on the module design, dynamic layer formation and process performance. The configurations tested on this study were: UASB followed by stone filter and three AnDMBRs in series with polyester pore sizes of 100 μm, 50 μm, and 5 μm; UASB followed by disc filter and the three AnDMBRs in series; UASB followed by the three AnDMBRs in series; and UASB reactor with only one AnDMBR module. Regarding the studied configurations, high removals of total suspended solids, chemical oxygen demand, and turbidity were achieved in all experimental setups. The use of stone and disc filters did not bring clear benefits to the system concerning the direct application of filtration with dynamic membranes, therefore, their removal in the system was favorable. The dynamic membrane formation was faster in the 50 μm mesh, and only a few hours were necessary to obtain a permeate quality with a total suspended solids concentration and a turbidity lower than 15 mg·L−1 and 30 NTU, respectively. Thus, the dynamic membrane technology proved to be a potential solution in the post-treatment of UASB reactor effluents.
Substrate-dependent Inhibition of Hypericin on Human Carboxylesterase 2: Implications
for Herb-drug Combination
Authors: Wang Dalong , Zhao Tingting , Zhao Shan , Chen Jing , Dou Tongyi , Ge Guangbo , Wang Changyuan , Sun Huijun , Liu Kexin , Meng Qiang , Wu Jingjing 
Published: February 2022

Background:
Hypericin is the main active ingredient of St. John’s wort, a Chinese herb commonly used
for treating depression. Previous studies shown that hypericin can strongly inhibit human cytochrome P450 (CYP)
enzyme activities; however, its potential interactions that inhibit human carboxylesterases 2 (hCE2) are unclear.

Purpose:
This study aimed to investigate the inhibitory effect of hypericin on hCE2.

Methods:
The inhibition mechanism of hypericin on hCE2 was studied by using N-(2-butyl-1,3-dioxo-2,3-dihydro-
1H-phenalen-6-yl)-2-chloroacetamide (NCEN). The type of inhibition of hypericin on hCE2 and the corresponding
inhibition constant (Ki) value were determined. The inhibition of hypericin on hCE2 in living cells was discussed.
The risk of herb-drug interactions (HDI) of hypericin in vivo was predicted by estimating the area under the drug
concentration-time curve (AUC) in the presence or absence of hypericin. To understand the inhibition mechanism of
hypericin on the activity of hCE2 in-depth, molecular docking was performed.

Results:
The half-maximal inhibitory concentration (IC50) values of hypericin against the hydrolysis of NCEN and
irinotecan (CPT-11) were calculated to be 26.59 μM and 112.8 μM, respectively. Hypericin inhibited the hydrolysis
of NCEN and CPT-11. Their Ki values were estimated as 10.53 μM and 81.77 μM, respectively. Moreover, hypericin
distinctly suppressed hCE2 activity in living cells. In addition, the AUC of hCE2 metabolic drugs with metabolic
sites similar to NCEN was estimated to increase by up to 5 % in the presence of hypericin. More importantly, the
exposure of CPT-11 in the intestinal epithelium was predicted to increase by 2 % - 69 % following the oral coadministration
of hypericin. Further, molecular simulations indicated that hypericin could strongly interact with
ASP98, PHE307, and ARG355 to form four hydrogen bonds within hCE2.

Conclusion:
These findings regarding the combination of hypericin-containing herbs and drugs metabolized by
hCE2 are of considerable clinical significance.
CEA-regulated Oncolytic Virus Anticancer Therapy: A Promising Strategy
for Rare Solid Tumors
Authors: Zha Yan , Li Ning , Yang Yuqi , Wang Shuhang , Ma Peiwen , Tang Qiyu , Li Yandong , Fang Yuan , Zhu Qi , Tao Wei 
Published: February 2022

Background:
Rare solid tumors have attracted much more attention due to the great unmet
clinical need, limited treatment options, and poor prognosis. As the most thoroughly studied tumor
marker, carcinoembryonic antigen (CEA) can not only overexpress in various common solid
tumors but also in several rare solid tumors. Oncolytic virus therapy has achieved excellent anticancer
effects in the past decades. Due to the specific high expression of CEA in certain tumor tissues
but not in normal tissues, CEA has been applied to improve the tumor specificity of gene expression.

Methods:
The studies of CEA expression in rare solid tumors and CEA-regulated oncolytic virus
therapy were reviewed.

Results:
We showed the types of rare solid tumors with the overexpression of CEA. Elevated
serum CEA levels can indicate the diagnosis, response of surgery or system therapy, distal metastasis,
recurrence, and survival. Due to high tumor specificity, CEA-regulated OA therapy has demonstrated
a surprising antitumor effect for common CEA-positive tumors in preclinical trials.

Conclusion:
These data suggested that CEA could be a diagnostic and prognostic biomarker for
several rare solid tumors. We proposed the hypothesis that CEA-regulated oncolytic virus therapy
could be a promising therapeutic strategy for CEA-positive rare solid tumors.
Design and Analysis of Pharmacokinetics, Pharmacodynamics and Toxicological
Analysis of Cannabidiol Analogs using In Silico Tools
Authors: Mendes Júnior Carlos Roberto , Costa Eduardo Damasceno 
Published: February 2022

Background:
Cannabidiol (CBD), a non-psychoactive phytocannabinoid from Cannabis Sativa,
has become an interesting option for medicinal chemists in the development of new drug candidates.

Objective:
This study aims to propose analogs with therapeutic potential from the CBD scaffold.

Methods:
The 16 analogs proposed were designed using the PubChem Sketcher V. 2.4® software. Already,
CBD analogs were subjected to different in silico tools, such as Molinspiration®; SwissADME®;
SwissTargetPrediction®, and OSIRIS Property Explorer®.

Results and Discussion:
The screening of CBD analogs carried out in this study showed compounds 9
and 16 with a good affinity for interactions with CB1 and CB2 receptors. Pharmacokinetic data showed
that these two compounds have good oral absorption. Finally, in silico toxicity data showed that these
compounds pose no risk of a toxic event in humans.

Conclusion:
CBD analogs 9 and 16 would have a better profile of drug candidates to be further tested in
vitro and in vivo models.
Potential of Caffeic Acid Derivatives as Antimalarial Leads
Authors: Degotte Gilles , Pirotte Bernard , Frédérich Michel , Francotte Pierre 
Published: February 2022

Background:
Malaria was one of the deadliest infectious diseases in 2021. Indeed, this infection,
mostly caused by a protozoan called Plasmodium falciparum, is responsible for more than 200 million
cases and around 400 000 related deaths annually, mainly in Africa. Despite the availability of effective
drugs, the number of patients has increased since 2015, which could be due to parasite resistance as
well as resistance in the pathogen's vectors, Anopheles mosquitoes. Consequently, it is necessary to search
for new alternative treatments.

Methods:
Polyphenols, more precisely small phenolic acids, could represent a good starting point for new
antimalarials. Indeed, these molecules, including caffeic acid (1), possess several pharmacological activities
and an interesting pharmacokinetic profile. Therefore, we have developed several small derivatives of
this scaffold to define the potential pharmacophore responsible for the antiplasmodial properties.

Results:
A good to low activity on Plasmodium falciparum (IC50 = 16-241 μM) was observed, especially
for the small ester derivatives (2-6). These molecules were good antiplasmodials compared to their mother
compound (IC50 = 80 μM) and showed selectivity against human cells. These structures have also highlighted
the need for catechol and carboxyl moieties in the anti-Plasmodium effect.

Conclusion:
None of the synthetic caffeate derivatives reported here seemed sufficiently effective to become
a potential antimalarial (IC50 < 1 μM). However, the significant increase of their efficacy on the
malarial agent and the selectivity to human cells highlighted their potential as new leads for future developments.
The Influence of Cultural and Psychological Factors on Mental Health Status during COVID-19 in Saudi Arabia
Authors: Alqahtani Azizah 
Published: February 2022

Background:The World Health Organization (WHO) announced a public health emergency of international concern (PHEIC) on 30 January 2020 due to the rapid increase in the number of COVID-19 cases outside China. Every pandemic is associated with other problems such as psychological and mental health problems.Methods:The current research investigated the relationship between mental health status and demographic variables and the psychological impact of COVID-19. Furthermore, this study explored the relationship between collectivism and low infection rates. The sample included 1700 adults aged 18 years and older. The questionnaire started with demographic questions followed by the Impact of Event Scale-Revised (IES-R), a scale that was applied to the COVID-19 outbreak, and the Depression, Anxiety and Stress Scale (DASS-21).Results:Findings indicated that depression, anxiety, and stress were associated with the psychological impact of COVID-19. In addition, students experienced a higher level of psychological impact of COVID-19 than other occupational groups. Finally, cultural collectivism was associated with a lower COVID-19 infection rate.Conclusion:It is recommended based on the findings of this paper that the mental health of university students should be observed and assessed during epidemics. Training regarding mental health should be provided to university faculty and staff.
Participatory Development in Community Health for the Pgazkoenyau Ethnic: A Case Study in an Ethnic Community in Thailand
Authors: Kitphati Rungrueng , Seangkeao Khampon , Muangyim Kamolnat , Nak-ai Worayuth 
Published: February 2022

Background:Most ethnic communities in Thailand were settled in remote areas with poor living conditions. Therefore, the “human-centered” concept was adopted to develop community health using the participation process.Objective:This research aimed to develop community health using the participation process at two Pgazkoenyau ethnic (Karen) communities whose environmental contexts were similar, in Tha Song Yang and Mae Ra Mard District, Tak Province.Methods:The multi-stage mixed methods design was applied for data collection. 24 participants were purposely recruited in the qualitative approach due to their responsibility as community health development operators. Qualitative data were collected using semi-structured interviews and analyzed using content analysis. In addition, quantitative data were gained through interview forms and laboratory test reports. Then they were analyzed using descriptive statistics, t-test to compare mean behavioral variables, and z-test to compare the proportion of two communicable diseases and blood chemical residues, with 95% confident interval.Results:The development process consisted of problem finding, data feedback and community stage, capacity building, operation, creative meeting, networking and social capitalizing. They could manage all activities following the community plan: identify helminthiasis and malaria cases, introduce cholinesterase test kits, improve community environmental health, improve healthy behaviors and build capacity for health promotion skills. Evaluated community activities showed increased scores concerning knowledge, attitudes and practices about disease prevention. The prevalence rate of helminths infection decreased significantly. The environmental context was also improved to enable the population’s healthy living conditions.Conclusion:Community development should be based on community resources and all available social and human capital for sustainable development.
Approaches to Determine and Manage Sexual Consent Abilities for People With Cognitive Disabilities: Systematic Review
Authors: Esmail Shaniff , Concannon Brendan 
Published: February 2022

Background
This review focused on how sexual consent ability was determined, managed, and enhanced in people with cognitive disabilities, with the aim of better understanding the recurring themes influencing the design and implementation of these approaches. If a person’s consensual ability becomes compromised, owing to either an early or late-onset cognitive disability, the formal systems involved must establish plans to balance the individual’s rights and restrictions on sexual expression. This review identified these plans, focusing on how they promoted the intimacy rights of the individual.

Objective
This study aims to identify approaches that determine sexual consent ability in people with cognitive disabilities, identify the means of managing and enhancing sexual consent ability in people with cognitive disabilities, and note the recurring themes that influence how these approaches and management systems are designed and implemented.

Methods
A systematic literature review was performed using EBSCOhost (Social Gerontology, CINAHL Plus, MEDLINE, and SocINDEX), Embase, PsyInfo, and Scopus to locate reports on terms expanded on sexual consent and cognitive disability.

Results
In all, 47 articles were identified, featuring assessment practices, legal case studies, and clinical standards for managing sexual consent capacity in people with cognitive disabilities. A total of 8 studies (5/8, 63% qualitative and 3/8, 38% quantitative) were included out of the 47 articles identified. Approaches for determining sexual consent included functional capacity and person-centered, integrated, and contextual approaches. Management of sexual consent ability included education, attitude, and advanced directives and support networks. The recurring themes that influenced these approaches included the 3 legal criteria of consent, American Bar Association and American Psychological Association Model, Lichtenberg and Strzepek Instrument, Ames and Samowitz Instrument, Lyden approach, Mental Capacity Act of 2005, and Vancouver Coastal Health Authority of 2009.

Conclusions
Determining sexual consent takes a holistic approach, with individuals judged in terms of their adaptive abilities, capacities, and human rights. The attitudes of those using this holistic approach need to be balanced; otherwise, the sexual rights of assessed people could be moved either in favor or against them. The ideal outcome, after person-centered considerations of those living with cognitive disabilities includes the people themselves being involved in the process of personalizing these approaches used to facilitate healthy intimate relationships.
Fernando Pérez Correa / Eduardo Torres Alonso / Andrea Samaniego Sánchez (2020), Protección del ambiente. Políticas, derechos y conflictos en México, México, UNAM
Authors: Ruiz López Cinthia Fabiola , Aguilar Pinto Emma Del Carmen 
Published: February 2022

Sobre la necesidad de pensar la protección del ambiente desde la mirada de los derechos humanos y los conflictos territoriales en México
Fotografía de Carlos Contrera
Authors: Contrera Carlos 
Published: February 2022

Este trabajo documental se realizó durante los diez años en que se llevó a cabo la restauración del Teatro Solís. La persistencia y la regularidad en la cobertura dejaron como resultado una enorme cantidad de materiales fotográficos sobre los cuales realicé una edición. Como documentalista edito siempre pensando en el posible lector o espectador: a él está dirigida toda mi atención. En estas fotografías muestro aquello que el lector no vio ni verá. Desde la delicadeza de la restauración del plafón de la sala a lo monumental de las estructuras de la caja escénica, con un elemento que las une: el hombre, realizador de toda la obra. Carlos Contrera, 1954, Cerro Chato.
Primer coloquio franco-latinoamericano de Comunicación Empresarial
Authors: Larre Borges María José 
Published: February 2022

El 4 y 5 de noviembre de 2009 se realizó en la Universidad Mayor de Santiago de Chile el Primer coloquio franco-latinoamericano de Comunicación Empresarial, denominado “La comunicación como estrategia para dar valor a la empresa”. En él participaron comunicadores, docentes y estudiantes de diferentes países de América Latina, incluida una nutrida delegación uruguaya. Las conferencias fueron realizadas por académicos y consultores latinoamericanos y franceses; por la Universidad Católica expuso Mónica Arzuaga.
ANALISIS KINERJA SAHAM-SAHAM INDIVIDUAL PERUSAHAANBUMN DI BURSA EFEK INDONESIAPERIODE JANUARI–DESEMBER 2010
Authors: . Chairani 
Published: February 2022

The purpose of this study was to explain the individual stock returns, systematic risk of the stock, stock performance and stock performance ratings of BUMN’s stock that start from Januari to Desember 2010. The Stocks performance were analyzed by calculating stock performance that using Jensen approach (αJ), rank the result, starting from the largest positive value to the smallest. The highest return of the stock was 0,2248 and the higest systematic risk was 114,618, ie., PT Semen Gresik Persero stocks, the best performance of the stock was 0,0361, i.e., PT Bank Negara Indonesia Persero stocks, and the worst performance was -0,1015 i.e., PT Semen Gersik Persero stock. This research result can be used as an investor consideration in assessing the performance of the company stock incorporated in BUMN that can provide the benefit as expected and indicate low systematic risk.Keywords: Stock Return, systematic risk of the stock, stock performance, Jensen Index(αJ),BUMN
BALANCING SECURITY AND LIBERTY
Authors: Kisilevsky Sari 
Published: February 2022

AbstractThis paper examines the legitimacy of the US government’s argument that it must “balance liberty and security” with regard to its policy of trying enemy belligerents in military commissions rather than federal courts. I distinguish between three senses of “balance,” and argue that the policy is ambiguous between the second (internal) and third (emergency external) senses of balance. Neither line of reasoning justifies the policy, however. On the second sense, it is unjustified because it constitutes an arbitrary limitation of the rights of some for the sake of the security of others. It thus violates the government’s duty to decide questions of policy in accordance with accepted legal procedures. Alternately, if the policy is intended to be an exercise of emergency powers, then it violates what I call the government’s juridical duty to serve as a guardian of justice. I offer an alternative justification for emergency measures, one that is based on the model of self-defense. I conclude that although the exercise of military commissions in times of emergency can be justified, the current exercise is illegitimate.