bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explicit Risk Management in Agile Software Projects: Its Relevance and Benefits
Authors: Thom-Manuel Osaki Miller 
Published: August 2022

Risk management is the systematic process of controlling risks and it is critical to the success of all software development projects. Agile software development methodologies by the inbuilt features utilized, control risks. However, this does not work for all cases of software development projects and supplementary means may need to be applied. This can be addressed by introducing an intentional and formal way of managing risks in the agile environment. Explicit risk management promises numerous benefits if properly implemented.
This study intends to review and deduce based on the risks identified, the relevance and benefits of formally managing risks in agile software development projects. To achieve the aim of this study, the researcher reviewed risk management procedures in a typical agile setting as well as research that exposed the insufficiency of the inherent risk management process in agile projects and the identified risks. Related research papers from peer-reviewed journals and other reliable sources were reviewed to extract risks that occurred using agile without explicit risks management. The study inferred that some risks do exist that occurred with the introduction and use of the agile method itself. Also, there could be risks that surface when the project size exceeds a limit. Thus, managing risks explicitly will go a long way to address such risks. Consequently, the researcher was able to deduce the relevance and benefits of implementing explicit risk management in an agile software development project.
This study showed that it is beneficial to incorporate formal risk management procedures in agile software development when mega software projects are being developed. However, to maintain the agility of the agile methods which happens to be a major benefit of the utilization of agile methods, more research is needed to further explore explicit risk management in the agile environment without violating the swiftness in the agile settings.
Predictive Value of TIMI Risk Index for Angiographic No-reflow after Primary Percutaneous Coronary Intervention
Authors: M. Ashmawy Medhat , A. Elgendy Ihab , K. Ibrahim Ibtsam , M. Abdulazim Mohamed 
Published: August 2022

Objective: In patients with acute coronary artery disease, the TIMI risk index (TRI), the thrombolysis in myocardial infarction (TIMI) risk score, and the global registry of acute coronary events (GRACE) risk score (GRS) have all been documented. The aim of this study was to determine the relationship between no-reflow (NRF) and admission TRI, major cardiac events (MACE), and in-hospital mortality in patients undergoing primary percutaneous coronary intervention (P-PCI).
Methods: Between March and December 2019, 100 consecutive patients diagnosed with STEMI and treated with PPCI at Tanta Main University Hospital in Tanta, Egypt, were included in the research population. Each patient consented following a thorough history taking, evaluation of coronary risk factors, clinical examination, and electrocardiogram analysis. Additionally, all instances were classified using the Killip method. The GRS, TRS, and TRI values were examined.
Results: The GRS, TRS, and TRI scores were significantly associated with increased NRF, MACE, and hospital mortality in STEMI patients treated with P-PCI, suggesting that TRI is a straightforward indicator with fewer parameters that accurately reflects P-PCI success.
Conclusion: TRI has been demonstrated to enhance the risk of in-hospital mortality and MACE. TRI uses straightforward and cost-effective ways to test patients who have experienced a STEMI. Additionally, a high TRI may assist in identifying high-risk individuals and developing suitable treatment solutions.
Physico-chemical Analysis of Fresh Persimmon (Diospyros kaki L) Fruit Pulp from Jammu Region India
Authors: Ayoub Anjum , Singh Jagmohan , Sharma Sushil 
Published: August 2022

This study was conducted in the division of the food science and technology SKUAST-Jammu in which the physicochemical analysis of the fruit of persimmon (Diospyros kaki L) was done in year 2020. The colour values L*, a*,b* values, crude protein content, crude fat content, solubility per cent, crude fibre, TSS, and ash per cent, total sugars per cent, ascorbic acid mg/100gm, total phenolic compounds mg GAE/g, Carbohydrates per cent ,FRAP nmol FeSo4/g were assessed. colour values were (L*) value of 99.6, (a*) value of 17.0, and (b*) value of 73.0, while solubility, moisture content, T.S.S, crude fibre, crude protein, crude fat, and ash content were found to be, respectively, 78.5percent, 76.83percent, 15.12ºBrix,13.5percent, 1.32 per cent. Titratable acidity for fresh persimmon pulp was 0.11 percent, and total sugar content was 14.60 percent.
Electrospun Tri‐Cation Perovskite Nanofibers for Infrared Photodetection
Authors: Kim Min‐Woo , Yuan Yihang , Jeong Sehee , Chong Jenny , Mølnås Håvard , Alaei Aida , Cleveland Iver J. , Liu Na , Ma Yichen , Strauf Stefan , Aydil Eray S. , Sahu Ayaskanta , Kalyon Dilhan M. , Lee Stephanie S. 
Published: August 2022

AbstractTri‐cation (Cs+/CH3NH3+/CH(NH2)2+) and dual‐anion (Br–/I–) perovskites are promising light absorbers for inexpensive infrared (IR) photodetectors but degrade under prolonged IR exposure. Here, stable IR photodetectors based on electrospun tri‐cation perovskite fibers infiltrated with hole‐transporting π‐conjugated small molecule 2,2′,7,7′‐tetrakis[N,N‐di(4‐methoxyphenyl)amino]‐9,9‐spirobifluorene (Spiro‐OMeTAD) are demonstrated. These hybrid perovskite photodetectors operate at a low bias of 5 V and exhibit ultra‐high gains with external quantum efficiencies (EQEs) as high as 3009%, decreasing slightly to ≈2770% after 3 months in air. These EQE values are almost ten times larger than those measured for photodetectors comprising bilayer perovskite/Spiro‐OMeTAD films. A high density of charge traps on electrospun fiber surfaces gives rise to a photomultiplication effect in which photogenerated holes can travel through the active layer multiple times before recombining with trapped electrons. Time‐resolved photoluminescence and conductive atomic force microscopy mapping reveal the improved performance of electrospun fibers to originate from the significantly enhanced interfacial surface area between the perovskite and Spiro‐OMeTAD compared to bilayers. As a solution‐based, scalable and continuous method of depositing perovskite layers, electrospinning thus presents a promising strategy for the inexpensive fabrication of high‐performance IR photodetectors for applications ranging from information technology to imaging.
Indenone Synthesis via Transition‐Metal‐Catalyzed Annulation
Authors: Hutchinson Lauren E. , Wilger Dale J. 
Published: August 2022

AbstractTransition‐metal‐catalyzed annulation reactions to synthesize indenones are reviewed, beginning with the Larock indenone synthesis and focusing on the most recent advances in technology. Proposed reaction mechanisms, and the evidence supporting them, are highlighted throughout this review. Current limitations in these reactions are described in detail. Obtaining high regioselectivity remains challenging with several different classes of alkyne. In particular, high‐yielding and regioselective reactions with alkyl‐substituted alkynes remain elusive, as do reactions with terminal alkynes. In the final section, the case is made that indanone synthesis reactions employing alkenes should be further explored.magnified image
Tonsillar Microbiome‐Derived Lantibiotics Induce Structural Changes of IL‐6 and IL‐21 Receptors and Modulate Host Immunity
Authors: Li Jing , Jin Jiayang , Li Shenghui , Zhong Yan , Jin Yuebo , Zhang Xuan , Xia Binbin , Zhu Yinhua , Guo Ruochun , Sun Xiaolin , Guo Jianping , Hu Fanlei , Xiao Wenjing , Huang Fei , Ye Hua , Li Ru , Zhou Yunshan , Xiang Xiaohong , Yao Haihong , Yan Qiulong , Su Li , Wu Lijun , Luo Tuoping , Liu Yudong , Guo Xiaohuan , Qin Junjie , Qi Hai , He Jing , Wang Jun , Li Zhanguo 
Published: August 2022

AbstractEmerging evidence emphasizes the functional impacts of host microbiome on the etiopathogenesis of autoimmune diseases, including rheumatoid arthritis (RA). However, there are limited mechanistic insights into the contribution of microbial biomolecules especially microbial peptides toward modulating immune homeostasis. Here, by mining the metagenomics data of
tonsillar microbiome, a deficiency of the encoding genes of lantibiotic peptides salivaricins in RA patients is identified, which shows strong correlation with circulating immune cells. Evidence is provided that the salivaricins exert immunomodulatory effects in inhibiting T follicular helper (Tfh) cell differentiation and interleukin‐21 (IL‐21) production. Mechanically, salivaricins directly bind to and induce conformational changes of IL‐6 and IL‐21 receptors, thereby inhibiting the bindings of IL‐6 and IL‐21 to their receptors and suppressing the downstream signaling pathway. Finally, salivaricin administration exerts both prophylactic and therapeutic effects against experimental arthritis in a murine model of RA. Together, these results provide a mechanism link of microbial peptides‐mediated immunomodulation.
A New Approach toward the Realization of Specific and Label‐Free Biological Sensing Based on Field‐Effect Devices
Authors: Bhattacharyya Ie Mei , Ron Izhar , Shima‐Edelstein Ruth , Pikhay Evgeny , Roizin Yakov , Shalev Gil 
Published: August 2022

AbstractSpecific and label‐free detection of biological interactions is paramount to a plethora of technological applications ranging from home‐care diagnostics to smart agriculture and home security. The biologically‐modified field‐effect transistor (BioFET) is a promising sensing platform due to its inherent signal amplification, low power, and miniaturization. In the following a low‐cost meta‐nano‐channel BioFET (MNC BioFET) is reported that provides means to electrostatically control the size, shape, and location of the conducting channel such as to enhance the coupling between the locally‐occurring electrostatics of the biological interactions and the electrodynamics of the underlying conducting channel. Moreover, it provides means to electrostatically control the Debye screening length at the sensing area to increase the readout signal. The MNC BioFET is fabricated in a large‐scale silicon chip foundry that ensures robustness and stability, optimal noise levels and signal amplification, repeatability, and ultimate miniaturization with the potential for high‐end multiplexing in ultra‐small samples. In the current study, a specific and label‐free sensing of prostate specific antigen with the MNC BioFET is demonstrated, and show the dependency of the sensor signal on the channel configuration. Finally, an order of magnitude enhancement in readout signal is demonstrated by the electrostatic control of the screening length at the sensing area.
Unraveling the Atomic Redox Process in Quantum Conductance and Synaptic Events for Neuromorphic Computing
Authors: Krishnan Karthik , Vijayaraghavan Saranyan 
Published: August 2022

AbstractManipulation of atomic point contact (APC) in memristive devices is considered as an essential approach in emulating biological synaptic functions and paves the way for developing neuromorphic computing systems. In this article, the conductance modulation in a polyvinylimidazole (PVI)‐based memristor that mimics the synaptic functions underlying the sensory memory, short‐term memory, long‐term memory, and forgetting events of the human brain, is demonstrated. A detailed analysis of resistive switching, quantum conductance, and synaptic behaviors in the silver (Ag) included PVI memristor is investigated by means of DC sweep and pulse current–voltage (I–V) measurements. Based on the synaptic plasticity of the Ag‐PVI memristor, the biological synaptic functions such as learning and forgetting two images are mimicked using 5 × 5 synaptic memristor arrays. To explain the relationship between the atomic redox process and synaptic events in the memristor, the I–V/cyclic voltammetry study is introduced. As a consequence, the concentration of charges in the APC region increases as the conductance state increases. This study is essential in order to explore the progressive growth of APC under confined redox reaction in the electrochemical metallization‐based memristors for developing both synaptic devices and high‐density multilevel memories.
Continuous‐flow Diels‐Alder Reactions of Unactivated Dienes over Zeolitic Catalysts
Authors: Masuda Koichiro , Agalave Sandip G. , Chen Wenlong , Onozawa Shun‐ya , Shimada Shigeru , Sato Kazuhiko , Kobayashi Shū 
Published: August 2022

AbstractDiels–Alder reactions of unactivated dienes with various dienophiles were investigated under continuous‐flow conditions. H‐beta zeolite was found to be a suitable catalyst for this type of transformation, allowing a good productivity of 1.88 kg/dm3⋅day space‐time yield and exhibiting excellent catalyst durability over >72 h of continuous operation. The catalyst was easily recyclable up to four times by simple calcination, without loss of activity.
What Matters for a European Research Council (ERC) Starting Grant?
Authors: Anastasaki Athina 
Published: August 2022

AbstractEuropean Research Council (ERC) Starting Grants are arguably the most competitive grants in Europe and their prestige is fully justified considering that they (i) allow focus on a high risk/high gain project through generous funding of 1.5–2 million Euros, (ii) they can enable the foundation of a new academic group and earn the submitting principal investigator a professorship, and (iii) they serve as a highly reputable award that can either facilitate tenure/promotion or assist in securing a subsequent academic position. However, the journey to getting one is far from easy. In this Viewpoint Article, I will discuss my first two unsuccessful attempts to secure an ERC Starting Grant and how the lessons learned during the process led me to ultimately secure a grant upon my third attempt.
Rechargeable LiNi0.65Co0.15Mn0.2O2||Graphite Batteries Operating at −60 °C
Authors: Yang Yusi , Chen Yifan , Tan Lulu , Zhang Jianwen , Li Nan , Ji Xiao , Zhu Yujie 
Published: August 2022

AbstractThe rechargeability of contemporary lithium‐ion batteries (LIBs) is challenging at low temperatures, mainly due to the hurdles faced by graphite anodes. Herein, by exploiting the Li‐solvent co‐intercalation into graphite, its low‐temperature rechargeability is boosted. Experimental characterizations aided by theoretical calculations demonstrate that the co‐intercalation process is featured by low interfacial resistance with a small charge transfer activation energy (0.23 eV atom−1) and an extremely low diffusion energy barrier (0.09 eV atom−1) which leads to nearly temperature‐independent diffusion coefficients of the solvated Li‐ion in graphite, enabling graphite to be stably charged‐discharged at −60 °C with 73.7 % of its room‐temperature capacity. Consequently, the full‐cell consisting of a LiNi0.65Co0.15Mn0.2O2cathode and a graphite anode shows impressive rechargeability under −60 °C. This work provides an alternative approach to develop low‐temperature rechargeable LIBs.
Static and Dynamic Gradient Based Directional Transportation of Neutral Molecules in Swollen Polymer Films
Authors: Ali Mohammad A. , Volmert Brett , Evans Christopher M. , Braun Paul V. 
Published: August 2022

AbstractMaterials which selectively transport molecules offer powerful opportunities for concentrating and separating chemical agents. Here, utilizing static and dynamic chemical gradients, transport of molecules within swollen crosslinked polymers is demonstrated. Using an ≈200 μm static hydroxyl to hexyl gradient, the neutral ambipolar nerve agent surrogate diethyl (cyanomethyl)phosphonate (DECP) is directionally transported and concentrated 60‐fold within 4 hours. To accelerate transport kinetics, a dynamic gradient (a “travelling wave”) is utilized. Here, the non‐polar dye pyrene was transported. The dynamic gradient is generated by an ion exchange process triggered by the localized introduction of an aqueous NaCl solution, which converts the gel from hydrophobic to hydrophilic. As the hydrophilic region expands, associated water enters the gel, and pyrene is pushed ahead of the expansion front. The dynamic gradient provides about 10‐fold faster transport kinetics than the static gradient.
An Inorganic Huisgen Reaction between a 1,2‐Diboraallene and an Azide to Access a Diboratriazole
Authors: Zhu Lizhao , Kinjo Rei 
Published: August 2022

AbstractRegioselective Huisgen cycloaddition reaction between 1,2‐diboraallene and azide proceeds under catalyst‐free and mild conditions to furnish a diboratriazole (2). X‐ray diffraction analysis and computational studies confirmed the delocalization of π electrons over the B2N3five‐membered ring of (2), indicating its aromatic features. Molecule (2) spontaneously releases N2to form the 2,3‐dibora‐4‐aza‐1,3‐butenyne derivative (3). The mechanism of a whole reaction profile was extensively investigated by density functional theory (DFT) calculations.
Lithium‐Ion Thermal Charging Cell with Giant Thermopower for Low‐Grade Heat Harvesting
Authors: Xu Yinghong , Li Zhiwei , Wu Langyuan , Dou Hui , Zhang Xiaogang 
Published: August 2022

AbstractLiquid‐based thermoelectric cells integrate energy harvesting and storage technology, becoming the focus of energy fields. However, the simultaneous implement of high output voltage and heat‐to‐electricity efficiency is still challenging. Herein, we propose a lithium‐ion thermal charging cell using lithium anode and electrospun zinc vanadate@carbon nanofiber cathode. Benefitting from the superior performance of electrode and the significant difference between the size of cation and anion in electrolyte, such system can continuously realize the harvesting and conversion of low‐grade heat into electricity. Consequently, an open‐circuit voltage of about 2.1 V can be generated at a low temperature gradient of 25 K together with an ultrahigh thermopower of 47.9 mV K−1and a remarkable power density of 9.2 W m−2. Moreover, an impressive Carnot‐related efficiency (5.2 %) can be achieved under same conditions. This work confirms the superiority of organic thermoelectric system and provides a new insight to develop promising thermal charging cell for sustainable applications.
Improved Interface Stability and Zinc‐Ions Distribution Achieved by Functional Protective Layer Containing Abundant Oxygen Sites and Regular Channels for Long‐Life Zinc‐Metal Anodes
Authors: Zhang Yue , Liu Tiancun , Ji Yaling , You Jianhua , Cai Chen , Wen Yi , Yao Zhujun , Yang Yefeng 
Published: August 2022

AbstractAqueous zinc (Zn)‐ion batteries (AZIBs) have attracted much attention for the high safety, economy and nontoxic property, but further practical applications are still hindered due to the severe interfacial corrosion and annoying dendrite growth. Herein, a functional protective layer (FPL) containing abundant oxygen sites and regular channels is proposed as the surface coating to stabilize the Zn‐metal anode. Specifically, transferred free water molecules and mitigated Zn‐ions can be attracted by these polar oxygen sites, beneficially reliving corrosion behavior, reducing side reactions and inducing uniform Zn deposition. Furthermore, the cross‐linked structure with opening channels of FPL benefits electrolyte to quickly arrive the electrode surface and maintain the superior movement of Zn‐ions. As a result, a superior cycling performance with high stability of 450 h at 5 mA cm−2and excellent rate behavior have been endowed by Zn electrode loading FPL. In the exploration of practical utilization, full battery consisting of Zn@FPL anode and cathode adopting commercial MnO2powder also exhibits an outstanding capacity retention of 98.9 % after 300 cycles at 0.5 A g−1. The proposed strategy of constructing a protective layer with functional sites and opening structure shows a good guiding significance for protecting Zn‐metal anode.
2D Catalysts for CO2 Photoreduction: Discussing Structure Efficiency Strategies and Prospects for Scaled Production Based on Current Progress
Authors: Yang Xiaohan , Li Kai , Wang Guangtao , Li Xiang , Zhou Pengyu , Ding Shichao , Lyu Zhaoyuan , Chang Yu‐Chung , Zhou Yuanzhen , Zhu Wenlei 
Published: August 2022

AbstractCurrently, the excessive consumption of fossil fuels is accompanied by massive emissions of CO2, leading to severe energy shortages and intensified global warming. It is of great significance to develop and use renewable clean energy while reducing the concentration of CO2 in the atmosphere. Photocatalytic technology is a promising strategy for carbon dioxide conversion. Clearly, the achievement of the above goals largely depends on the design and construction of catalysts. This review is mainly focused on the application of 2D materials for photocatalytic CO2 reduction. The contribution of synthetic strategies to their structure and performance is emphasized. Finally, the current challenges, and prospects of 2D materials for photoreduction of CO2 with high efficiency, even for practical applications are discussed. It is hoped that this review can provide some guidance for the rational design, controllable synthesis of 2D materials, and their application for efficient photocatalytic CO2 reduction.
Transient neurochemical features of the perigeniculate neurons during early postnatal development of the cat
Authors: Merkulyeva Natalia , Mikhalkin Аleksandr , Kostareva Anna , Vavilova Tatyana 
Published: August 2022

AbstractThe thalamic reticular nucleus receives axons from the thalamic sensory nuclei and the cerebral cortex. The visual part of this nucleus in carnivores is the perigeniculate nucleus located dorsal to the lateral geniculate nucleus. The perigeniculate nucleus participates in the modulation of visual processing and in the transition of synchronized slow rhythmicity during sleep into desynchronized high‐frequency activity during arousal and consists of inhibitory neurons. The main neurochemical markers for perigeniculate neurons are glutamic acid decarboxylase and Ca2+‐binding protein parvalbumin. Previous studies of postnatal development focused on the morphological features of the perigeniculate nucleus; however, its neurochemistry remains poorly understood. In this study, we focused on the postnatal development of perigeniculate neurons using immunohistochemical labeling of parvalbumin, two related Ca2+‐binding proteins (calretinin and calbindin), glutamic acid decarboxylase, and a common neuronal protein, NeuN, in kittens that were 0–123 days old and in adult cats. In parallel with the well‐known dominant neuronal populations expressing parvalbumin and GAD67 and persisting until adulthood, transient populations expressing calretinin and calbindin were observed. The calbindin‐positive neurons were similar to the main perigeniculate population and showed close morphological features and parvalbumin coexpression. In contrast, the calretinin‐positive neurons differed in their morphological characteristics and did not express GAD67, thus distinguishing them from the majority of perigeniculate neurons. A possible link between these populations was revealed, and the development of thalamocortical processing is discussed.