bluuebunny/crossref_metadata_2025_split huggingface dataset:
Male intake of omega-3 fatty acids and risk of intimate partner violence perpetration: a nationwide birth cohort – the Japan Environment and Children's Study
Authors: Matsumura Kenta , Hamazaki Kei , Tsuchida Akiko , Inadera Hidekuni ,   the Japan Environment and Children's Study (JECS) Group
Published: June 2022

Abstract

Aims
Intake of omega-3 polyunsaturated fatty acids (PUFAs) has favourable effects on reducing aggressive and violent behaviours, but its association with perpetration of intimate partner violence (IPV) is not known. We aimed to determine the association between male intake of omega-3 PUFAs and risk of IPV perpetration.

Methods
Participants were male–female pairs in the Japan Environment and Children's Study, in which first pregnant women and then their partners were enrolled (analytic sample: n = 48 065). Male intake of omega-3 PUFAs during the past year (preconception to mid/late pregnancy) was determined using a food frequency questionnaire. IPV (physical violence and emotional abuse) during pregnancy was measured using a self-reported questionnaire completed by pregnant women in mid/late pregnancy. Generalised additive mixed-model analysis was used to examine the non-linear association between energy-adjusted male omega-3 PUFA intake and the adjusted prevalence of male IPV perpetration.

Results
A sharply decreasing regression curve was plotted for physical violence, with prevalence starting at 1.35% at the lowest intake level and decreasing to a minimum value of 0.76% at intake of 2.20 g/day (71.7th percentile). However, prevalence largely remained flat from there onward, with the upper limit of the error range not reaching the initial lower limit of the error range until intake exceeded 5.21 g/day (99.77th percentile). For emotional abuse, on the other hand, there was a distorted U- or V-shaped regression curve that rose slightly after reaching a minimum. The prevalence declined from 17.69% initially, reached a minimum at 12.44% at 2.13 g/day (68.3th percentile), and then rose slightly. The lower limit of the error range reached the minimum upper limit at 4.17 g/day (99.1th percentile), and the upper limit finally reached the maximum lower limit value at 4.56 g/day (99.5th percentile).

Conclusions
In this nationwide birth cohort study, higher male intake of omega-3 PUFAs was associated with lower risk of physical violence and emotional abuse perpetration except for extremely high intake. Our results indicate the potential applicability of omega-3 PUFAs in reducing aggressive and violent behaviours in IPV.
Trial registration: UMIN000030786.
Mega‐Depressions on the Cocos Ridge: Links Between Volcanism, Faults, Hydrothermal Circulation, and Dissolution
Authors: Kluesner Jared W. , Silver Eli A. , Bangs Nathan L. , Ranero César R. , Nale Stephanie , Gibson James , McIntosh Kirk D. 
Published: June 2022

AbstractHigh‐resolution bathymetry and three‐dimensional seismic data along the Cocos Ridge reveal a 245 km2 field of ∼1–4 km in diameter seafloor depressions. The seafloor depressions are part of a two‐tiered honeycomb pattern. The lower‐tier depressions have steep faults that truncate strata with chaotic internal reflections consistent with sediment collapse into the depression. These extend into a lens shaped interval just above igneous basement. Overlying these depressions is a second broader set with rough seafloor morphology with gently dipping boundaries defined by pinch‐out stratigraphic patterns. Drilling results indicate that the lens‐shaped zones that host the deeper depressions represent anomalous regions of high porosity, low velocity, and low density within calcareous rich sediment. Analysis of nannofossils from IODP Site U1414 suggests the collapse structures formed during the late Miocene, whereas the younger shallower depressions likely formed between the early Pliocene and the Pliocene‐Pleistocene boundary. Geochemical and petrological analysis at Site U1414 suggests that hydrothermal circulation during the late Miocene led to carbonate dissolution and collapse. Following collapse, focused fluid‐flow and bottom current scouring resulted in formation of the overlying set of depressions and a honeycomb seafloor morphology. Similar sets of depressions along the Carnegie Ridge to the south support the hypothesis that two‐tiered depressions formed in response to processes that occurred broadly across the Panama Basin between the late Miocene and the Pliocene‐Pleistocene transition. Geochemical results at Site U1414, combined with geophysical data, suggest this two‐tiered system of depressions currently guides ongoing fluid outflow.
Statistical Evaluation of the Temperature Forecast Error in the Lower‐Level Troposphere on Short‐Range Timescales Induced by Aerosol Variability
Authors: Yamagami A. , Kajino M. , Maki T. 
Published: June 2022

AbstractThis study statistically evaluated the aerosol impact on the temperature error in the lower‐level troposphere in short‐range numerical weather prediction (NWP). The Global Ensemble Forecast System version 12 (GEFSv12) reforecast exhibited large‐temperature errors in high‐loading areas (North India, Africa, South America, and China). In 1‐day GEFSv12 forecasts, the largest average temperature error occurred in the aerosol optical depth (AOD) peak month, and the daily error distribution corresponded to the daily AOD distribution. Even though the temperature error in the 1‐day operational forecasts was smaller than that in the GEFSv12 forecasts, the forecast uncertainties in the operational forecasts were comparable to those in 3‐day GEFSv12 forecasts over high‐loading areas. The daily temperature errors in all NWP models exhibited a correlation coefficient of ∼0.5–0.6 for the AOD over Central Africa and northern South America and ∼0.3–0.6 for AOD anomalies over China and northern South America. These results indicated that the interannual aerosol variability contributed 25–36% to errors, and the daily variability contributed 10%–36% to temperature errors in 3‐day forecasts. Although the correlation was low, aerosol impacts also emerged in North India and Central Africa. Partial correlation and composite analysis suggested that the direct effect mainly influenced temperature forecast errors over northern South America, whereas both direct and indirect effects influenced temperature errors over China. Model intercomparison revealed that operational NWP models could experience common forecast errors associated with aerosols in high‐loading areas.
Sensitivities of Cross‐Tropopause Transport in Midlatitude Overshooting Convection to the Lower Stratosphere Environment
Authors: Gordon Andrea E. , Homeyer Cameron R. 
Published: June 2022

AbstractTropopause‐overshooting convection in the midlatitudes rapidly transports lower troposphere air and cloud material to the upper troposphere and lower stratosphere (UTLS), with notable events resulting in the formation of above‐anvil cirrus plumes (AACPs). However, there is limited understanding of how transport driven by overshooting convection and AACP properties are modified by variations in UTLS environments, especially the extent of stratosphere‐to‐troposphere (i.e., downward) transport. Here, AACP development and UTLS transport sensitivities to lower stratosphere stability and the UTLS wind environment are evaluated. The Bryan Cloud Model is used to simulate midlatitude supercell convection and evaluate resulting UTLS composition changes within two common midlatitude thermodynamic environments: a single tropopause and a double tropopause, and two UTLS wind environments: one with a stronger stratospheric wind profile supportive of frequent gravity wave breaking and AACP development and the other with a weaker stratospheric wind profile to suppress gravity wave breaking and discourage AACP formation. Multiple passive tracers and water vapor concentrations are used to evaluate the exchange of air between the troposphere and stratosphere and transport confined to each layer. It is found that greater troposphere‐to‐stratosphere transport (TST) and stratospheric hydration occurs in storms with AACPs, while stratosphere‐to‐troposphere transport (STT) is greater in storms without AACPs. This STT is facilitated by a mechanical oscillation induced by the overshoot. AACP‐producing storms have increased downward transport of stratospheric overworld air to the lowermost stratosphere, which is enhanced within a double tropopause environment. More expansive AACPs, deeper overshoots, and greater TST also occurs in double tropopause environments.
A Dynamic Pore Network Model for Imbibition Simulation Considering Corner Film Flow
Authors: Zhao Jianlin , Qin Feifei , Kang Qinjun , Qin Chaozhong , Derome Dominique , Carmeliet Jan 
Published: June 2022

AbstractWetting films can develop in the corners of angular pores under strong wetting conditions. Modeling the dynamics of corner film remains elusive using direct numerical simulations because of the significant scale difference between main meniscus and corner film flow. In this paper, the modified interacting capillary bundle model (ICB), developed in our previous work to describe accurately corner film dynamics in a single square tube, is incorporated into a single‐pressure dynamic pore network model (DPNM) to simulate imbibition in strongly wetting porous media with corner film flow. The traditional pore network is decomposed into several layers of interacting subpore networks where the 0th layer of subpore network simulates the main meniscus flow and higher layers the corner film flow. The fluid flow between different layers is captured by interlayer throats. In addition, the snap‐off mechanism caused by the thickening of wetting corner film is considered. The accuracy of the developed model is validated for four cases: spontaneous imbibition in a single square tube, wetting fluid redistribution through corner films under a capillary pressure difference, snap off in a narrow throat connecting two large pores, and imbibition dynamics in a real microfluidic porous geometry. The validated model is then used to simulate both spontaneous and controlled imbibition in a pore network with random pore size distribution. The interaction between corner film and main meniscus flow in porous media is analyzed from a pore‐scale perspective.
Acid sphingomyelinase/ceramide system in schizophrenia: implications for therapeutic intervention as a potential novel target
Authors: Zhuo Chuanjun , Zhao Feifei , Tian Hongjun , Chen Jiayue , Li Qianchen , Yang Lei , Ping Jing , Li Ranli , Wang Lina , Xu Yong , Cai Ziyao , Song Xueqin 
Published: June 2022

AbstractSchizophrenia is a severe mental illness, as the efficacies of current antipsychotic medications are far from satisfactory. An improved understanding of the signaling molecules involved in schizophrenia may provide novel therapeutic targets. Acid sphingomyelinase (ASM) catalyzes cellular membrane sphingomyelin into ceramide, which is further metabolized into sphingosine-1-phophate (S1P). ASM, ceramide, and S1P at the cell surface exert critical roles in the regulation of biophysical processes that include proliferation, apoptosis, and inflammation, and are thereby considered important signaling molecules. Although research on the ASM/ceramide system is still in its infancy, structural and metabolic abnormalities have been demonstrated in schizophrenia. ASM/ceramide system dysfunction is linked to the two important models of schizophrenia, the dopamine (DA) hypothesis through affecting presynaptic DA signaling, and the vulnerability-stress-inflammation model that includes the contribution of stress on the basis of genetic predisposition. In this review, we highlight the current knowledge of ASM/ceramide system dysfunction in schizophrenia gained from human and animal studies, and formulate future directions from the biological landscape for the development of new treatments. Collectively, these discoveries suggest that aberrations in the ASM/ceramide system, especially in ASM activity and levels of ceramide and S1P, may alter cerebral microdomain structure and neuronal metabolism, leading to neurotransmitter (e.g., DA) dysfunction and neuroinflammation. As such, the ASM/ceramide system may offer therapeutic targets for novel medical interventions. Normalization of the aberrant ASM/ceramide system or ceramide reduction by using approved functional inhibitors of ASM, such as fluvoxamine and rosuvastatin, may improve clinical outcomes of patients with schizophrenia. These transformative findings of the ASM/ceramide system in schizophrenia, although intriguing and exciting, may pose scientific questions and challenges that will require further studies for their resolution.
Bateman gradients from first principles
Authors: Lehtonen Jussi 
Published: June 2022

AbstractIn 1948, Angus Bateman presented experiments and concepts that remain influential and debated in sexual selection. The Bateman gradient relates reproductive success to mate number, and Bateman presented this as the cause of intra-masculine selection. A deeper causal level was subsequently asserted: that the ultimate cause of sex differences in Bateman gradients is the sex difference in gamete numbers, an argument that remains controversial and without mathematical backup. Here I develop models showing how asymmetry in gamete numbers alone can generate steeper Bateman gradients in males. This conclusion remains when the further asymmetry of internal fertilisation is added to the model and fertilisation is efficient. Strong gamete limitation can push Bateman gradients towards equality under external fertilisation and reverse them under internal fertilisation. Thus, this study provides a mathematical formalisation of Bateman’s brief verbal claim, while demonstrating that the link between gamete number and Bateman gradients is not inevitable nor trivial.
Neutralization of Omicron BA.1, BA.2, and BA.3 SARS-CoV-2 by 3 doses of BNT162b2 vaccine
Authors: Kurhade Chaitanya , Zou Jing , Xia Hongjie , Cai Hui , Yang Qi , Cutler Mark , Cooper David , Muik Alexander , Jansen Kathrin U. , Xie Xuping , Swanson Kena A. , Shi Pei‑Yong 
Published: June 2022

AbstractThe newly emerged Omicron SARS-CoV-2 has several distinct sublineages including BA.1, BA.2, and BA.3. BA.1 accounts for the initial surge and is being replaced by BA.2, whereas BA.3 is at a low prevalence at this time. Here we report the neutralization of BNT162b2-vaccinated sera (collected 1 month after dose 3) against the three Omicron sublineages. To facilitate the neutralization testing, we have engineered the complete BA.1, BA.2, or BA.3 spike into an mNeonGreen USA-WA1/2020 SRAS-CoV-2. All BNT162b2-vaccinated sera neutralize USA-WA1/2020, BA.1-, BA.2-, and BA.3-spike SARS-CoV-2s with titers of >20; the neutralization geometric mean titers (GMTs) against the four viruses are 1211, 336, 300, and 190, respectively. Thus, the BA.1-, BA.2-, and BA.3-spike SARS-CoV-2s are 3.6-, 4.0-, and 6.4-fold less efficiently neutralized than the USA-WA1/2020, respectively. Our data have implications in vaccine strategy and understanding the biology of Omicron sublineages.
Mnemonic construction and representation of temporal structure in the hippocampal formation
Authors: Bellmund Jacob L. S. , Deuker Lorena , Montijn Nicole D. , Doeller Christian F. 
Published: June 2022

AbstractThe hippocampal-entorhinal region supports memory for episodic details, such as temporal relations of sequential events, and mnemonic constructions combining experiences for inferential reasoning. However, it is unclear whether hippocampal event memories reflect temporal relations derived from mnemonic constructions, event order, or elapsing time, and whether these sequence representations generalize temporal relations across similar sequences. Here, participants mnemonically constructed times of events from multiple sequences using infrequent cues and their experience of passing time. After learning, event representations in the anterior hippocampus reflected temporal relations based on constructed times. Temporal relations were generalized across sequences, revealing distinct representational formats for events from the same or different sequences. Structural knowledge about time patterns, abstracted from different sequences, biased the construction of specific event times. These findings demonstrate that mnemonic construction and the generalization of relational knowledge combine in the hippocampus, consistent with the simulation of scenarios from episodic details and structural knowledge.
Anderson transition in stoichiometric Fe2VAl: high thermoelectric performance from impurity bands
Authors: Garmroudi Fabian , Parzer Michael , Riss Alexander , Ruban Andrei V. , Khmelevskyi Sergii , Reticcioli Michele , Knopf Matthias , Michor Herwig , Pustogow Andrej , Mori Takao , Bauer Ernst 
Published: June 2022

AbstractDiscovered more than 200 years ago in 1821, thermoelectricity is nowadays of global interest as it enables direct interconversion of thermal and electrical energy via the Seebeck/Peltier effect. In their seminal work, Mahan and Sofo mathematically derived the conditions for ’the best thermoelectric’—a delta-distribution-shaped electronic transport function, where charge carriers contribute to transport only in an infinitely narrow energy interval. So far, however, only approximations to this concept were expected to exist in nature. Here, we propose the Anderson transition in a narrow impurity band as a physical realisation of this seemingly unrealisable scenario. An innovative approach of continuous disorder tuning allows us to drive the Anderson transition within a single sample: variable amounts of antisite defects are introduced in a controlled fashion by thermal quenching from high temperatures. Consequently, we obtain a significant enhancement and dramatic change of the thermoelectric properties from p-type to n-type in stoichiometric Fe2VAl, which we assign to a narrow region of delocalised electrons in the energy spectrum near the Fermi energy. Based on our electronic transport and magnetisation experiments, supported by Monte-Carlo and density functional theory calculations, we present a novel strategy to enhance the performance of thermoelectric materials.
A broadly neutralizing antibody protects Syrian hamsters against SARS-CoV-2 Omicron challenge
Authors: Zhou Biao , Zhou Runhong , Tang Bingjie , Chan Jasper Fuk-Woo , Luo Mengxiao , Peng Qiaoli , Yuan Shuofeng , Liu Hang , Mok Bobo Wing-Yee , Chen Bohao , Wang Pui , Poon Vincent Kwok-Man , Chu Hin , Chan Chris Chung-Sing , Tsang Jessica Oi-Ling , Chan Chris Chun-Yiu , Au Ka-Kit , Man Hiu-On , Lu Lu , To Kelvin Kai-Wang , Chen Honglin , Yuen Kwok-Yung , Dang Shangyu , Chen Zhiwei 
Published: June 2022

AbstractThe strikingly high transmissibility and antibody evasion of SARS-CoV-2 Omicron variants have posed great challenges to the efficacy of current vaccines and antibody immunotherapy. Here, we screen 34 BNT162b2-vaccinees and isolate a public broadly neutralizing antibody ZCB11 derived from the IGHV1-58 family. ZCB11 targets viral receptor-binding domain specifically and neutralizes all SARS-CoV-2 variants of concern, especially with great potency against authentic Omicron and Delta variants. Pseudovirus-based mapping of 57 naturally occurred spike mutations or deletions reveals that S371L results in 11-fold neutralization resistance, but it is rescued by compensating mutations in Omicron variants. Cryo-EM analysis demonstrates that ZCB11 heavy chain predominantly interacts with Omicron spike trimer with receptor-binding domain in up conformation blocking ACE2 binding. In addition, prophylactic or therapeutic ZCB11 administration protects lung infection against Omicron viral challenge in golden Syrian hamsters. These results suggest that vaccine-induced ZCB11 is a promising broadly neutralizing antibody for biomedical interventions against pandemic SARS-CoV-2.
hnRNPH1 recruits PTBP2 and SRSF3 to modulate alternative splicing in germ cells
Authors: Feng Shenglei , Li Jinmei , Wen Hui , Liu Kuan , Gui Yiqian , Wen Yujiao , Wang Xiaoli , Yuan Shuiqiao 
Published: June 2022

AbstractCoordinated regulation of alternative pre-mRNA splicing is essential for germ cell development. However, the underlying molecular mechanism that controls alternative mRNA expression during germ cell development remains elusive. Herein, we show that hnRNPH1 is highly expressed in the reproductive system and recruits the PTBP2 and SRSF3 to modulate the alternative splicing in germ cells. Conditional knockoutHnrnph1in spermatogenic cells causes many abnormal splicing events, thus affecting the genes related to meiosis and communication between germ cells and Sertoli cells. This is characterized by asynapsis of chromosomes and impairment of germ-Sertoli communications, which ultimately leads to male sterility. Markedly,Hnrnph1germline-specific mutant female mice are also infertile, andHnrnph1-deficient oocytes exhibit a similar defective synapsis and cell-cell junction as seen inHnrnph1-deficient male germ cells. Collectively, our data support a molecular model wherein hnRNPH1 governs a network of alternative splicing events in germ cells via recruitment of PTBP2 and SRSF3.
Dietary supplementation with biogenic selenium nanoparticles alleviate oxidative stress-induced intestinal barrier dysfunction
Authors: Qiao Lei , Zhang Xinyi , Pi Shanyao , Chang Jiajing , Dou Xina , Yan Shuqi , Song Xiaofan , Chen Yue , Zeng Xiaonan , Zhu Lixu , Xu Chunlan 
Published: June 2022

AbstractSelenium (Se) is an essential micronutrient that promotes body health. Endemic Se deficiency is a major nutritional challenge worldwide. The low toxicity, high bioavailability, and unique properties of biogenic Se nanoparticles (SeNPs) allow them to be used as a therapeutic drug and Se nutritional supplement. This study was conducted to investigate the regulatory effects of dietary SeNPs supplementation on the oxidative stress-induced intestinal barrier dysfunction and its association with mitochondrial function and gut microbiota in mice. The effects of dietary SeNPs on intestinal barrier function and antioxidant capacity and its correlation with gut microbiota were further evaluated by a fecal microbiota transplantation experiment. The results showed that Se deficiency caused a redox imbalance, increased the levels of pro-inflammatory cytokines, altered the composition of the gut microbiota, and impaired mitochondrial structure and function, and intestinal barrier injury. Exogenous supplementation with biogenic SeNPs effectively alleviated diquat-induced intestinal barrier dysfunction by enhancing the antioxidant capacity, inhibiting the overproduction of reactive oxygen species (ROS), preventing the impairment of mitochondrial structure and function, regulating the immune response, maintaining intestinal microbiota homeostasis by regulating nuclear factor (erythroid-derived-2)-like 2 (Nrf2)-mediated NLR family pyrin domain containing 3 (NLRP3) signaling pathway. In addition, Se deficiency resulted in a gut microbiota phenotype that is more susceptible to diquat-induced intestinal barrier dysfunction. Supranutritional SeNPs intake can optimize the gut microbiota to protect against intestinal dysfunctions. This study demonstrates that dietary supplementation of SeNPs can prevent oxidative stress-induced intestinal barrier dysfunction through its regulation of mitochondria and gut microbiota.