bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary red blood cell‐derived microparticles and phosphatidylserine‐exposing red blood cells in glomerular and non‐glomerular hematuria patients
Authors: Charoensappakit Awirut , Puapatanakul Pongpratch , Praditpornsilpa Kearkiat , Palasuwan Attakorn , Noulsri Egarit , Palasuwan Duangdao 
Published: June 2022

AbstractBackgroundDistinguishing glomerular hematuria (GH) from non‐glomerular hematuria (NGH) is important for treating the cause of hematuria. We aimed to determine red blood cell‐derived microparticles (RMPs) and phosphatidylserine (PS)‐exposing red blood cells (RBCs) and evaluate their use for diagnosing GH and NGH patients.MethodsAll patients received a physical assessment and urological examination. Dysmorphic RBCs (dRBCs) and acanthocytes were examined using a light microscope. The urinary RMPs and PS‐exposing RBCs were determined using flow cytometry.ResultsThe ratio of RMPs to RBCs was higher in GH patients (n = 29) than in NGH patients (n = 29) (1.06 vs. 0.18). The value of the sum of the PS‐exposing RBCs plus RMPs divided by the number of RBCs was higher in GH patients than in NGH patients (48.3% vs. 19.4%). The percentage of RBCs was higher in GH patients than in NGH patients (54.5% vs. 21.8%). Similarly, both the percentages of acanthocytes and of non‐acanthocytes were higher in GH patients than in NGH patients (29% vs. 7.7% and 25.4% vs. 14.2%, respectively). The ROC‐AUC of the number of PS‐exposing RBCs plus RMPs divided by the number of RBCs was 0.9 (95% CI, 0.82–0.97), and the RMPs:RBCs ratio was 0.88 (95% CI, 0.79–0.98). The ROC‐AUCs of the dRBCs and acanthocytes were 0.85 (95% CI, 0.78–0.95) and 0.88 (95% CI, 0.8–0.97), respectively.ConclusionsPatients with GH have higher numbers of urinary RMPs and PS‐exposing RBCs. These parameters have the potential to be predictive tools for classifying GH in the future.
Catalytic Isomerization of Unprotected Mesoionic N‐Heterocyclic Olefins and Their Lewis Adducts
Authors: Qu Zheng‐Wang , Zhu Hui , Streubel Rainer , Grimme Stefan 
Published: June 2022

AbstractRecently, novel C5‐position‐unprotected mesoionic N‐heterocyclic olefins (mNHOs) demonstrated interesting reactivity with various Lewis acids during experiments. In this work, extensive DFT calculations show that the isomerization of such mNHOs to more Lewis‐basic mesoionic carbenes (MICs) can be efficiently catalyzed by weakly protic acidic species including C5‐unprotected mNHOs, their Lewis adducts and polar H2O molecules, thus enabling catalytic isomerization and H‐isotope exchange of such mNHOs and their Lewis adducts.
Deriving and comparing priority vectors for revised‐leachate pollution index (r‐LPI) using three fuzzy analytic hierarchy process
Authors: Bisht Tribhuwan Singh , Kumar Dinesh , Alappat Babu J. 
Published: June 2022

AbstractThe revised leachate pollution index (r‐LPI) developed using the fuzzy Delphi analytical hierarchy process (FDAHP) is a technique to quantify the contamination potential of landfill leachate. The steps involved in the formulation of the r‐LPI were the selection of parameters using the fuzzy Delphi method (FDM), computing relative weights of the parameters using the fuzzy analytic hierarchy process (FAHP), development of sub‐index curves, and finally, aggregation of sub‐indices. The calculation of the weights of the parameters has been one of the most crucial steps in the formulation of any index. The analytical hierarchy process (AHP) has been one of the most widely used methods for weight calculation. However, it was observed that the traditional AHP is inadequate to deal with the imprecise or ambiguous nature of linguistic evaluation. It also involves human subjectivity, which induces ambiguity and entails the use of decision‐making with uncertainty. The fuzzy AHP method was used in this study to overcome this difficulty. Three significant issues pertinent and essential to fuzzy AHP were addressed: contradictions in expert judgment, deriving priorities from inconsistent fuzzy judgment matrices, and group decision‐making. In this study, three FAHP methods: Chang's extent analysis (EA) method, fuzzy preference programming (FPP), and logarithmic fuzzy preference programming (LFPP) were used to calculate the weights of the r‐LPI parameters. The results of these methods were then compared, and it was determined that LFPP was the most suitable method for calculating the weights of the r‐LPI parameters.
Repurposing and recycling wind turbine blades in the United States
Authors: Martini Ryan , Xydis George 
Published: June 2022

AbstractWind energy is increasing in popularity worldwide as a low‐cost, carbon‐free energy technology. As deployment continues to grow, owners will need to conduct planning for end‐of‐life strategies for the components that are large in volume, number, and not readily recyclable in the operational form. Since the first modern, utility‐scale wind turbines were installed in the 1990s, a large number of wind turbines are reaching their end‐of‐life (typically 20–25 years) and each year an increasing number of blades are decommissioned. To stimulate efficient turbine reuse and recycling industry, industry and public funding should be allocated to support: research and testing processing methods, implementing potential applications of the material, and incentivizing successful applications for reuse of the material. Since the blades are the component most exposed to the elements and least easily recycled, this work will focus on their post‐operation applications. This work discusses the current literature on wind turbine blade reuse and recycling, proposing suggestions for applications of the materials and policy support. The work also estimates that by the years 2043–2050, only based on the development zones announced on the East Coast, a cumulative of 2.4 million metric tons (t) of wind blades would be needed to be repurposed and recycled.
Experimental and numerical engine cycle setup for a dual fuel hydrogen, methane, and hythane with diesel to assess the effect of water injection and nozzle geometry
Authors: Taghavifar Hadi 
Published: June 2022

AbstractIn this study, the potential of gaseous fuels such as hydrogen, methane, and hythane in combination with diesel fuel is assessed in a closed loop thermodynamic framework. An experimental test is conducted with basic diesel fuel and then the model is configured based on the realistic one‐cylinder diesel engine to evaluate the robustness and reliability of the simulation. The model is accurate in terms of in‐cylinder pressure, temperature, and heat release rate within the 3% error band. In principle, three blend cases of diesel50%—methane50%, diesel50%—hydrogen50%, and diesel50%—hythane50% are compared with baseline neat diesel from engine performance to emissions characteristics. For hythane and hydrogen‐involved fuels, the 10% water injection effect is analyzed as well to damp the high flammability and ignition intensity of hydrogen. The findings indicate that the entropy generation in hythane and hydrogen is markedly higher than in diesel case, while water injection can slightly decrease the entropy amount. It is shown that D50H50 has more fuel consumption in higher nozzle diameter (28% at 1 mm hole diameter), while in lower nozzle size range pure diesel fuel consumption dominates. The results revealed that D50Hy40W10 is particularly effective for elevated torque at lower nozzle hole values since the steam contributes toward maximized pressure and the exerted force. The increase of the nozzle number resulted in the CO content increase in the exhaust with the burning temperature reduction.
Relationships between autistic traits, taste preference, taste perception, and eating behaviour
Authors: Chen Na , Watanabe Katsumi , Kobayakawa Tatsu , Wada Makoto 
Published: June 2022

AbstractIndividuals with autism spectrum disorder exhibit atypical taste perception and eating behaviours. However, little is known about the effect of autistic traits on eating behaviours in the general population. This study explored the relationships between autistic traits, taste preferences, taste perceptions, and eating behaviours among Japanese population using an online questionnaire survey. The results showed significant effect of autistic traits on eating behaviours, that people with higher autistic traits tended to have higher selective eating behaviours, such as increased sensitivity to food texture and mixed flavours. Moreover, selective eating behaviours were correlated with the preference for sour taste and aftertaste sensitivity. Those results suggest that eating behaviours can be influenced by the relationship between autistic traits, taste perceptions, and taste preferences. We discuss these results in the context of previous findings, and future investigations into the possibility of solving selective eating problems in individuals with autism.
Medical cannabis and automobile accidents: Evidence from auto insurance
Authors: Ellis Cameron M. , Grace Martin F. , Smith Rhet A. , Zhang Juan 
Published: June 2022

AbstractWhile many states have legalized medical cannabis, many unintended consequences remain under‐studied. We focus on one potential detriment–the effect of cannabis legalization on automobile safety. We examine this relationship through auto insurance premiums. Employing a modern difference‐in‐differences framework and zip code‐level premium data from 2014 to 2019, we find that premiums declined, on average, by $22 per year following medical cannabis legalization. The effect is more substantial in areas near a dispensary and in areas with a higher prevalence of drunk driving before legalization. We estimate that existing legalization has reduced health expenditures related to auto accidents by almost $820 million per year with the potential for a further $350 million reduction if legalized nationally.
Centralization and innovation: Competing priorities for health systems?
Authors: Scarffe Andrew D. , Coates Alison , Evans Jenna M. , Grudniewicz Agnes 
Published: June 2022

AbstractOver the last 15 years, there has been a trend in Canada to centralise the provision of health services that were previously administratively and fiscally decentralised. Canadian policy rhetoric on centralisation often identifies improved innovation as an anticipated outcome. This paper challenges the assumed relationship between centralisation and innovation. We incorporate evidence from the management literature into the debate on the structure of health systems to explore the effects that centralisation is likely to have on innovation in health systems. The findings of this paper will be of interest to international policymakers, who are currently grappling with the prospect of maintaining a decentralised approach or adopting a more centralised health system structure in the future.
Retroperitoneal myofibroblastoma in an 88‐year‐old male
Authors: Watari Shogo , Ichikawa Takaharu , Shiraishi Hiromasa , Sakuma Takafumi , Kubota Risa , Kusumi Norihiro , Tsushima Tomoyasu , Nagakita Keina , Shinno Yoko 
Published: June 2022

IntroductionExtramammary myofibroblastomas are extremely rare.Case presentationThe patient was an 88‐year‐old male. He presented for evaluation of frequent urination and a “pushing up” sensation from the groin during defecation. Thorough physical and radiographic examinations revealed a retroperitoneal tumor on the right side of the rectum. The pathologic examination of the biopsy tissue showed that the tumor was unlikely to be malignant. Nevertheless, the patient was symptomatic and thus underwent a laparoscopic tumor resection through a transperitoneal approach. The tumor was circumscribed with a solid capsule. Based on the pathologic findings, which included immunostaining, the tumor was diagnosed as a myofibroblastoma. There was no evidence of a recurrence 6 months postoperatively.ConclusionWe present this case with the clinical course and surgical findings, and discuss the possibility of establishing a preoperative pathologic diagnosis of a myofibroblastoma.
Microlens‐assisted microscopy for biology and medicine
Authors: Trukhova Anna , Pavlova Marina , Sinitsyna Olga , Yaminsky Igor 
Published: June 2022

AbstractThe addition of dielectric transparent microlens in the optical scheme is an effective and at the same time simple and inexpensive way to increase the resolution of a light microscope. For these purposes, spherical and cylindrical microlenses with a diameter of 1–100 μm are usually used. The microlens focuses the light into a narrow beam called a photonic nanojet. An enlarged virtual image is formed, which is captured by the objective of the light microscope. In addition to microscopy, the microlenses are successfully applied to amplify optical signals, increase the trapping force of optical tweezers and are used in microsurgery. This review considers the design and principle of microlens‐assisted microscopes. Taking into account the advantages of the super‐resolution optical methods for research in life science, the examples of the use of the microlenses in biomedical practice are discussed in detail.
Antidiabetic and neuroprotective effects of a novel repaglinide analog
Authors: Foroumadi Roham , Baeeri Maryam , Asgarian Sara , Emamgholipour Zahra , Goli Fereshteh , Firoozpour Loghman , Keykhaei Mohammad , Gholami Mahdi , Dehpour Ahmad R. , Abdollahi Mohammad , Foroumadi Alireza 
Published: June 2022

AbstractRepaglinide (RPG) is an oral insulin secretagogue used in the treatment of diabetes. In this study, a new RPG analog was synthesized. Its antidiabetic and neuroprotective effects on dorsal root ganglions (DRG) in streptozotocin (STZ)‐induced diabetic rats were examined compared to RPG. To assess the effects of 2‐methoxy‐4‐(2‐((3‐methyl‐1‐(2‐(piperidin‐1‐yl)phenyl)butyl)amino)‐2‐oxoethoxy)benzoic acid (OXR), the impact of OXR on oxidative stress biomarkers, motor function, and the expression of the glutamate dehydrogenase 1 (GLUD1), SLC2A2/glucose transporter 2 (GLUT2), and glucokinase (GCK) genes in STZ‐induced diabetic rats were assessed. DRGs were examined histologically using hemotoxylin and eosin staining. Molecular docking was used to investigate the interactions between OXR and the binding site of RPG, the ATP‐sensitive potassium (KATP) channel. Following 5 weeks of treatment, OXR significantly increased the level of total antioxidant power, decreased reactive oxygen species, and lipid peroxidation in the DRGs of diabetic rats. OXR restored STZ‐induced pathophysiological damages in DRG tissues. Administration of OXR improved motor function of rats with diabetic neuropathy. Administration of 0.5 mg/kg OXR reduced blood glucose while promoting insulin, mainly through upregulation of messenger RNA expression of GLUD1, GLUT2, and GCK in the pancreas. Molecular docking revealed a favorable binding mode of OXR to the KATP channel. In conclusion, OXR has neuroprotective effects in diabetic rats by lowering oxidative stress, lowering blood glucose, and stimulating insulin secretion. We report that 0.5 mg/kg OXR administration was the most effective concentration of the compound in this study. OXR may be a promising target for further research on neuroprotective antidiabetic molecules.
Second malignant neoplasms after treatment of 1487 children and adolescents with acute lymphoblastic leukemia—A population‐based analysis of the Austrian ALL‐BFM Study Group
Authors: Poyer Fiona , Dieckmann Karin , Dworzak Michael , Tamesberger Melanie , Haas Oskar , Jones Neil , Nebral Karin , Köhrer Stefan , Moser Reinhard , Kropshofer Gabriele , Peters Christina , Urban Christian , Mann Georg , Pötschger Ulrike , Attarbaschi Andishe ,   the Austrian Berlin‐Frankfurt‐Münster (BFM) Study Group
Published: June 2022

AbstractSecond malignant neoplasms (SMN) after primary childhood acute lymphoblastic leukemia (ALL) are rare. Among 1487 ALL patients diagnosed between 1981 and 2010 in Austria, the 10‐year cumulative incidence of an SMN was 1.1% ± 0.3%. There was no difference in the 10‐year incidence of SMNs with regard to diagnostic‐, response‐ and therapy‐related ALL characteristics except for a significantly higher incidence in patients with leukocytes ≥50.0 G/L at ALL diagnosis (2.1% ± 1.0% vs. 0% for 20.0–50.0 G/L, and 1.0% ± 0.3% for < 20.0 G/L; p = 0.033). Notably, there was no significant difference in the incidence of SMNs between patients with or without cranial radiotherapy (1.2% ± 0.5% vs. 0.8% ± 0.3%; p = 0.295). Future strategies must decrease the incidence of SMNs, as this event still leads to death in one‐third (7/19) of the patients.
How to infuse an organizational culture with humility: A study of humble behaviors and practices
Authors: Cuenca Renato , Tomei Patricia Amelia , Mello Sylvia Freitas 
Published: June 2022

AbstractIn order to analyze the role of humility in organizational culture, in this work, companies that formally declared humility as a value on their home pages were chosen, as to understand the internalization of this value in their practices and behaviors. The research adopted a descriptive‐analytical design with a qualitative approach, and in addition to secondary data referring to the organizational profile, fourteen semi‐structured interviews were analyzed with the decision‐making elite of the seven chosen organizations, based on theoretical‐deductive categories of the construct identified in the organizational literature. The study identified that the value of humility is effectively present in behaviors and practices of these organizations, which develop a culture of humility in their daily lives. The main results indicate that the internalized value of humility is associated with (i) shared behaviors; (ii) clear self‐assessment of strengths and weaknesses; (iii) culture of innovation; (iv) awareness of their own limitations; (v) support for third‐party contributions and feedback practices (vi) employee learning; (vii) culture of praise. The results reinforced the main categories and constructs for a Humble Organizational Culture (HOC) Model, opening opportunities for future research that explore the elaboration of cultural maturity diagnoses and humility measurement instruments in the organizational field.
Probiotic consumption can modify the resilience of periodontal tissues in rats under experimental periodontitis
Authors: de Oliveira Luiz Fernando Ferreira , Silva Pedro Henrique Felix , Salvador Sergio Luiz , Ervolino Edilson , Casarin Renato , Figueiredo Luciene , Ricoldi Milla Tavares , de Souza Sérgio Luís Scombatti , Furlaneto Flavia , Messora Michel Reis 
Published: June 2022

AbstractBackgroundThis study evaluated the effects of systemic administration of Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) on experimental periodontitis (EP) in rats.MethodsThirty‐two rats were allocated to groups C (control), C‐HN019 (probiotic), EP (EP only), and EP‐HN019 (EP+probiotic). From day 0, the animals of C‐HN019 and EP‐HN019 groups received B. lactis HN019 (1 × 109 CFU/ml) daily. On the 14th day, the animals of EP and EP‐HN019 groups received silk ligature around mandibular molars. Animals were euthanized on the 28th day. Samples of oral biofilm, gingival tissues, blood serum, and mandible were obtained for microtomographic, histomorphometric, microbiological, and immunological analyses. Data were statistically analyzed (p < 0.05).ResultsGroup EP‐HN019 presented significantly less alveolar bone loss when compared with Group EP in histomorphometric and microtomographic analyses. In gingival tissue and serum, Group EP‐HN019 presented lower proinflammatory/anti‐inflammatory cytokines ratios than Group EP. Group EP‐HN019 showed higher expression of beta‐defensins and less TRAP‐positive cells than Group EP. Group EP presented higher gene expression of Ifng and lower gene expression of Foxp3 when compared with Group EP‐HN019 in gingival tissue. In oral biofilm, EP‐HN019 group presented a lower percentage of species similar to Fusobacterium periodonticum and a higher percentage of species similar to Actinomyces gereneseriae, Actinomyces israelli, and Streptococcus gordonii when compared with Group EP. There was a significant increase of B. lactis HN019 after administration of probiotic therapy in oral biofilm of Group EP‐HN019.ConclusionThe consumption of B. lactis HN019 promotes a protective effect against alveolar bone loss by modifying local and systemic microbiological and immunoinflammatory parameters.
Eurotium cristatum reduces obesity by alleviating gut microbiota dysbiosis and modulating lipid and energy metabolism
Authors: Zhang Bo , Ren Daoyuan , Zhao Aiqing , Cheng Yukun , Liu Yueyue , Zhao Yan , Yang Xingbin 
Published: June 2022

AbstractBACKGROUNDFuzhuan brick tea (FBT) has been shown to prevent obesity, but little is known about the effect of Eurotium cristatum, a critical fungus from FBT. This study examined the effects of live E. cristatum on lipid metabolism and gut microbiota composition in high‐fat (HF) diet‐induced obese mice.RESULTSMale HF diet‐fed mice were treated with E. cristatum for 12 weeks. The results showed that E. cristatum administration caused strong inhibition against HF‐induced body weight gain, dyslipidemia and liver oxidative stress damage. Additionally, Firmicutes and Bacteroidetes in phylum level and six types of bacterial including short‐chain fatty acids (SCFAs) producing bacteria in genus level were found to be significantly changed in E. cristatum treated mice as compared to HF fed mice. As expected, E. cristatum could increase total SCFAs levels in feces. Interestingly, E. cristatum markedly increased the proportion of Akkermansia to resist obesity. Functional prediction analysis indicated that E. cristatum changed lipid and energy metabolism. Furthermore, E. cristatum ingestion can modulate hepatic acetyl‐coa carboxylase (ACC), fatty acid synthase (FAS), sterol‐regulatory element binding protein‐1 (SREBP‐1) and adipose uncoupling protein‐1 (UCP‐1) expression.CONCLUSIONConclusively, these findings suggest that E. cristatum can prevent the HF‐induced lipid accumulation and other complications by modulating gut microbiota, lipid and energy metabolism. © 2022 Society of Chemical Industry.
The effects of tea polyphenol‐ozonated slurry ice treatment on the quality of large yellow croaker (Pseudosciaena crocea) during chilled storage
Authors: Lan Weiqing , Chen Xuening , Zhao Yanan , Xie Jing 
Published: June 2022

AbstractBACKGROUNDThe aim of the current study was to evaluate the synergistic effects of tea polyphenol‐ozonated slurry ice on the quality, physicochemical and protein characteristics of large yellow croaker (Pseudosciaena crocea) during chilled (4 °C) storage. To 0.3% tea polyphenol combined with ozone water was added sodium chloride until the salt concentration reached 3.3% and with the use of an ice machine the mixture formed the tea polyphenol‐ozonated slurry ice. Microbial [total viable count (TVC)], physicochemical [total volatile basic nitrogen (TVB‐N), K value], myofibrillar fragmentation index (MFI), Ca2+‐ATPase activity, total sulfhydryl content, intrinsic fluorescence intensity (IFI), Fourier‐transform infrared (FTIR), scanning electron microscopy (SEM) and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS‐PAGE) were analyzed during chilled (4 °C) storage for up to 20 days.RESULTSThe results showed that tea polyphenol‐ozonated slurry ice could effectively inhibit the increase of TVC and TVB‐N, reduce the degree of adenosine triphosphate (ATP) degradation. In addition, the tea polyphenol‐ozonated slurry ice treatment could protect the integrity of myosin in myofibrillar proteins (MPs) by inhibiting the decrease of Ca2+‐ATPase activity and the content of total sulfhydryl. Furthermore, the tea polyphenol‐ozonated slurry ice presented a superiorly protective effect on protein structure in MPs as manifested by the results of IFI, FTIR and SDS‐PAGE. It was possible that due to the addition of tea polyphenol, the antioxidant activity of this complex was significantly improved.CONCLUSIONThe tea polyphenol‐ozonated slurry ice treatment can maintain the quality of large yellow croaker by decreasing the damage of MP caused by the interaction between microorganisms and endogenous enzymes. © 2022 Society of Chemical Industry.