bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel long non‐coding RNA CYB561‐5 promotes aerobic glycolysis and tumorigenesis by interacting with basigin in non‐small cell lung cancer
Authors: Li Longfei , Li Zhimin , Qu Jingming , Wei Xiangju , Suo Feng , Xu Jilei , Liu Xiucheng , Chen Chang , Zheng Shiying 
Published: January 2022

AbstractAbnormally expressed long non‐coding RNAs (lncRNAs) have been recognized as potential diagnostic biomarkers or therapeutic targets in non‐small cell lung cancer (NSCLC). The role of the novel lnc‐CYB561‐5 in NSCLC and its specific biological activity remain unknown. In this study, lncRNAs highly expressed in NSCLC tissue samples compared with paired adjacent normal tissue samples and atypical adenomatous hyperplasia were identified by RNA‐seq analysis. Lnc‐CYB561‐5 is highly expressed in human NSCLC and is associated with a poor prognosis in lung adenocarcinoma. In vivo, downregulation of lnc‐CYB561‐5 significantly decreases tumour growth and metastasis. In vitro, lnc‐CYB561‐5 knockdown treatment inhibits cell migration, invasion and proliferation ability, as well as glycolysis rates. In addition, RNA pulldown and RNA immunoprecipitation (RIP) assays show that basigin (Bsg) protein interacts with lnc‐CYB561‐5. Overall, this study demonstrates that lnc‐CYB561‐5 is an oncogene in NSCLC, which is involved in the regulation of cell proliferation and metastasis. Lnc‐CYB561‐5 interacts with Bsg to promote the expression of Hk2 and Pfk1 and further lead to metabolic reprogramming of NSCLC cells.
Clinical utility of a serum glycome analysis in patients with colorectal cancer
Authors: Takei Daisuke , Harada Keita , Nouso Kazuhiro , Miyahara Koji , Dohi Chihiro , Matsushita Hiroshi , Kinugasa Hideaki , Hiraoka Sakiko , Nishimura Shin‐Ichiro , Okada Hiroyuki 
Published: January 2022

AbstractBackground and AimSerum glycans are known to be good markers for the early diagnosis and prognostic prediction in many cancers. The aims of this study were to reveal the serum glycan changes comprehensively during the process of carcinogenesis from colorectal adenoma (CRA) to colorectal cancer (CRC) and to evaluate the usefulness of the glycan profiles as clinical markers for CRC.MethodsSerum samples were obtained from 80 histologically proven CRC and 36 CRA cases. The levels of glycans in the serum were examined with a comprehensive, quantitative, high‐throughput unique glycome analysis, and their diagnostic and prognostic abilities were evaluated.ResultsAmong 34 stably detected glycans, nine were differentially expressed between CRC and CRA. Serum levels of hybrid type glycans were increased in patients with CRC compared with those with CRA (P < 0.001), and both hybrid‐type and multi‐antennary glycans were significantly increased in advanced cancer cases. The glycan, m/z 1914, showed the highest diagnostic value among the decreased glycans, whereas m/z 1708 showed the highest among the increased glycans. The glycan ratio m/z 1708/1914 showed a higher area under the receiver operating characteristic curve (0.889) than any other single glycan or conventional tumor marker, such as carcinoembryonic antigen (0.766, P = 0.040) and carbohydrate antigen 19‐9 (0.615, P < 0.001). High m/z 1708/1914 was also correlated with an advanced cancer stage and short overall survival.ConclusionSerum glycans, especially the m/z 1708/1914 ratio, were useful for the diagnosis, staging, and prognosis prediction of CRC.
Preventing, mitigating, and managing future pandemics for people with an intellectual and developmental disability ‐ Learnings from COVID‐19: A scoping review
Authors: Taggart Laurence , Mulhall Peter , Kelly Rosie , Trip Henrietta , Sullivan Bill , Wallén Eva Flygare 
Published: January 2022

AbstractMany people with an intellectual and developmental disability (IDD) are biologically, socially, and economically/politically vulnerable to developing SARS‐COV‐2 (COVID‐19) compared to the general population. Most governments have developed public‐health policies and strategies to address the challenges that COVID‐19 has presented. These policies and strategies have been based upon the general population and in fact could be detrimental to the health and well‐being of people with IDD. This paper provides a review of the key learning points emerging from the COVID‐19 literature, together with guidance for the provision of services and government interventions for people with an IDD for future pandemics. Using guidance from the Joanna Briggs Institute, a scoping review was used to explore the current literature (scientific and grey) on IDD and COVID‐19. Three core themes emerged from the review. Prevention/protection: User‐friendly accurate accessible information, handwashing and social distancing, Personal Protective Equipment, shielding, track and trace, testing, vaccine compliance/hesitancy, and training. Mitigation: Making reasonable adjustments both to where people live, and to community healthcare/clinical practice; and the use of technology as a pandemic‐response strategy. Treatment/Management: Access to acute hospitals and lifesaving equipment, using a suitable clinical fatality assessment instrument, stopping Do Not Resuscitate notices, individualised care plans and hospital passports, family/paid carers to support people in hospitals; and use of telehealth in clinical care. This is the first international scoping review that provides a narrative synthesis of emerging themes related to the COVID‐19 pandemic and people with an IDD. This paper highlights themes related to preventing, mitigating, and treating/managing the care of this population during the COVID‐19 pandemic, which can inform future public‐health policies. This paper also exposes the negative impacts of public‐health interventions in both High‐Income Countries and Low‐Middle Income Countries for this population including lapses in upholding human rights. These data provide a basis for learning from the COVID‐19 pandemic in planning for future pandemics.
Discovery and characterization of sweetpotato’s closest tetraploid relative
Authors: Muñoz‐Rodríguez Pablo , Wells Tom , Wood John R. I. , Carruthers Tom , Anglin Noelle L. , Jarret Robert L. , Scotland Robert W. 
Published: January 2022

Summary

The origin of sweetpotato, a hexaploid species, is poorly understood, partly because the identity of its tetraploid progenitor remains unknown. In this study, we identify, describe and characterize a new species of Ipomoea that is sweetpotato’s closest tetraploid relative known to date and probably a direct descendant of its tetraploid progenitor.

We integrate morphological, phylogenetic, and genomic analyses of herbarium and germplasm accessions of the hexaploid sweetpotato, its closest known diploid relative Ipomoea trifida, and various tetraploid plants closely related to them from across the American continent.

We identify wild autotetraploid plants from Ecuador that are morphologically distinct from Ipomoea batatas and I. trifida, but monophyletic and sister to I. batatas in phylogenetic analysis of nuclear data.

We describe this new species as Ipomoea aequatoriensis T. Wells & P. Muñoz sp. nov., distinguish it from hybrid tetraploid material collected in Mexico; and show that it likely played a direct role in the origin of sweetpotato’s hexaploid genome. This discovery transforms our understanding of sweetpotato’s origin.
Using telehealth for oral medicine patient management during the COVID‐19 lockdown
Authors: Polonowita Ajith , Guan Guangzhao , Thomson W. Murray , Martin‐Hendrie Reuben 
Published: January 2022

AbstractAimTo investigate patient and clinician feedback on remote telehealth consultations to determine their feasibility for use as an adjunct service.MethodsA cross‐sectional investigation of satisfaction with telehealth consultations. In total, one oral medicine specialist, four dentists and 88 patients were surveyed.ResultsA total of 88 video consultations were completed with patients in Christchurch and Wellington hospitals. There was always a dentist present with the patient during the consultation. Overall, 95.5% of patients found the experience to be comfortable, with no systematic differences by sex, age, ethnicity or reason for the visit. Most patients were satisfied with the treatment received during the video consultations. Fewer patients who presented with pain were satisfied with the treatment received than were those who presented with oral mucosal disorders or other issues (61.8%, 75.0% and 76.9%, respectively). Both the oral medicine specialist and clinicians involved found the process comfortable and did not find diagnostic capabilities to be compromised.ConclusionVideo telehealth might be a valid alternative or adjunct to face‐to‐face consultations. This may open the way for remote video consultations to improve the availability of oral medicine services in rural areas.
Quality of life of caregivers supporting neurologically impaired patients who underwent surgery
Authors: Imagawa Kentaro , Fukahori Suguru , Hashizume Naoki , Saikusa Nobuyuki , Higashidate Naruki , Ishii Shinji , Masui Daisuke , Sakamoto Saki , Tsuruhisa Shiori , Nakahara Hirotomo , Tanaka Yoshiaki , Yagi Minoru , Yamashita Yushiro 
Published: January 2022

AbstractBackgroundA questionnaire survey was conducted to clarify whether surgical treatments performed by a pediatric surgeon improve the quality of life (QOL) of caregivers (medical doctors, nurses, physical therapists, and nursery teachers) supporting neurologically impaired (NI) patients who work at specialized institutions.MethodsThe questionnaire survey was conducted with caregivers who cared for NI patients who underwent an operation at the Department of Pediatric Surgery, Kurume University Hospital. Quality‐of‐life related responses concerning the change of care after surgical procedures in NI patients were collected in addition to the background data related to caregivers and the surgical procedures performed for them. Degrees of difficulty in caring for NI patients and of the caregivers’ own QOL postoperatively were also compared.ResultsThere were 192 valid responses. The majority of responses were from females and nurses aged in their 40s and 50s. The surgical procedure performed most often in the NI patients was gastrostomy. Of the respondents, 77% answered that the postoperative care became easier. The degrees of difficulty in caring for NI patients and the caregivers’ own QOL were significantly higher and lower, respectively, among physical therapists compared with caregivers in other occupations. Moreover, the QOL in respondents with factors related to a longstanding relationship with NI patients was significantly higher compared with the respondents without them.ConclusionThis survey indicated that surgical procedures for NI patients might contribute to improved QOL for the caregiver by reducing the difficulty of caring for NI patients.
Morphological and pathogenic characterization of Corynespora cassiicola isolates reveals specific genotypic interactions in soybean
Authors: Toulet María Laura , Neira Diego A. , Escobar Marcela , Pardo E. Mariano , Arias Marta E. , Ploper Leonardo Daniel , Welin Björn , Castagnaro Atilio Pedro , Chalfoun Nadia Regina 
Published: January 2022

AbstractSoybean target spot, caused by the fungus Corynespora cassiicola, is an important disease in northwestern Argentina (NWA). A cultural, morphological, and virulence characterization of 24 C. cassiicola isolates from different geographic localities in NWA was performed. The isolates were classified into five different cultural phenotypes, one of which has not been previously described. The ribosomal DNA internal transcribed spacer region sequence from five representative isolates (587 bp) exhibited 100% identity with C. cassiicola. A high variability of conidial morphology was observed among isolates, but no correlation with cultural phenotype was observed. When the soybean cultivar A 8000 RG was challenged with the 24 isolates, different degrees of virulence were observed, ranging from highly virulent to nonvirulent. No association of virulence with cultural or morphological characters was observed, but a relationship with geographical origin was demonstrated. Histopathological studies were performed on a nonvirulent and a highly virulent isolate. Microscopic observations of infected tissues of the former showed low mycelium development restricted to the upper epidermis, a thickening of the cuticle and primary wall of subepidermal cells, and accumulation of callose in phloematic vessels. In tissue infected with the latter, there was abundant mycelium development accompanied by cellular disorganization in mesophyll cells. Pathological challenges of isolates on nine different cultivars indicated that the degree of virulence of isolates depends on the plant genotype, demonstrating that the C. cassiicola–soybean interaction is highly specific. Understanding the genetic basis of this interaction will provide new information for better disease management and breeding strategies.
The dentist as the gatekeeper of systemic health: A case report
Authors: Teicher Ross , Henschel Marc 
Published: January 2022

AbstractMany in the dental field often practice with blinders—they focus on the decay in front of them, the crown that must be prepared, the canal that must be shaped. The series of events that led to that existing issue, the underlying habit, disease, etc. is often overlooked. Many in our profession have gotten into the habit of becoming “tooth mechanics,” fixing several issues and ensuring that our patients leave with adequate oral health, rather than addressing the larger, often systemic issues that resulted in the state of their oral health. Although the steps within this large diagnostic process often require the formation of a multidisciplinary healthcare team comprised of different fields in healthcare unique to each patient, this idea is often overlooked. Our case report examines unique and surprising oral health findings that prompted the formation of such a team. Our role as a valued member of the healthcare team should be of paramount importance to our practice, and this case discusses a patient whose health required such. The conversation between physician and dentist is of continued importance and in this case one will be able to identify how systemic health is ultimately preserved and improved in this conversation.
Spatialising happiness economics: Global metrics, urban politics, and embodied technologies
Authors: Pykett Jessica 
Published: January 2022

AbstractHappiness has become a high‐profile goal for national governments, city authorities, and technology developers finding new ways to map and measure emotions through happiness economics, urban management, and digital emotion‐sensing. This paper advances critical geographical analysis of the neglected rationales, mechanisms, and implications of promoting the emotion of happiness. Researchers, policy‐makers, and publics alike are intrigued and troubled by how a growing concern with mapping and monitoring human happiness can co‐occur with increasing levels of social inequality, human suffering, anxiety, and sadness. The paper outlines the intersection between three key trajectories (economisation, spatialisation, and technologisation) in order to demonstrate how particular assumptions about space, time, scale, and subjectivity are implied in the framing of happiness as an objective scientific construct to be measured, and as a problem of government. These trajectories combine to create what I term a new spatial science of emotions, which is yet to be defined, empirically documented, and critically analysed. It considers what kind of economic futures and contested knowledge practices are laid out by this new spatial science of emotions. By bringing together insights from critical economic geographies of neuroscientific and behavioural forms of governance, geographies of well‐being, and social theories of embodied technologies, the paper challenges researchers to shift attention from subjective well‐being to public well‐being.
Deep convolutional neural networks architecture for an efficient emergency vehicle classification in real-time traffic monitoring
Authors: Kherraki Amine , El Ouazzani Rajae 
Published: January 2022

Nowadays, intelligent transportation system (ITS) has become one of the most popular subjects of scientific research. ITS provides innovative services to traffic monitoring. The classification of emergency vehicles in traffic surveillance cameras provides an early warning to ensure a rapid reaction in emergency events. Computer vision technology, including deep learning, has many advantages for traffic monitoring. For instance, convolutional neural network (CNN) has given very good results and optimal performance in computer vision tasks, such as the classification of vehicles according to their types, and brands. In this paper, we will classify emergency vehicles from the output of a closed-circuit television (CCTV) camera. Among the advantages of this research paper is providing detailed information on the emergency vehicle classification topic. Emergency vehicles have the highest priority on the road and finding the best emergency vehicle classification model in realtime will undoubtedly save lives. Thus, we have used eight CNN architectures and compared their performances on the Analytics Vidhya Emergency Vehicle dataset. The experiments show that the utilization of DenseNet121 gives excellent classification results which makes it the most suitable architecture for this research topic, besides, DenseNet121 does not require a high memory size which makes it appropriate for real-time applications.<p> </p>
Age and Medicare Insurance are Barriers to Telemedicine Access—A Quality Improvement Project
Authors: Madabhushi Vashisht , McLouth Christopher J. , King Robert , Bhakta Avinash , Beck Sandra , Patel Jitesh A. 
Published: January 2022

Background Telehealth use has had widespread expansion and adoption over the past two years. This study aims to evaluate access to telehealth essentials (TE) using a novel metric. Methods This single institute study surveyed outpatient surgical patients to determine their access to TE. Generalized linear mixed models were used to determine the relationship of demographic and county-level variables on access to four TE. Results 138 patients were surveyed. Sixty-six (47.8%) were from Appalachian Kentucky. In the survey cohort, 122 (88.4%) had smart phones, 109 (80.7%) had devices with video messaging capabilities, 106 (80.9%) had cellular reception, and 112 (82.4%) had access to WiFi. Increasing age and Medicare insurance were the most consistent predictors of lack of access to TE. Conclusion Rural Appalachian Kentucky has access to TE. Telehealth has the potential to decrease the healthcare inequity in rural populations, but incompletely address this inequity for the aging population.
Survivors of domestic abuse and sexual violence within sexual health services, how we responded, who is missing and what should be done?
Authors: Heskin Joseph , Wyatt Rose , Hepworth Eleanor , Cassidy Sean , Melendez-Torres GJ , Cohen Charlotte 
Published: January 2022

Background Reports of domestic abuse (DA) and sexual violence (SV) continue to rise across the UK, and sexual health services are well situated to offer a safe setting for disclosure. Methods We performed a retrospective analysis of all safeguarding proformas completed between April and September 2019 across three sexual health clinics in London. Results 158 patients reported current and/or historical DA and/or SV during the collection period. 70% of cohort identified as female, 28% as male and 2% as transgender. 25% of the cohort identified as gay men. Black and Asian attendees were disproportionately represented in the survivor cohort. 86% were offered a same-day appointment with the health advisor team and assessment for onward referral to specialist services. Almost half of the cohort were asymptomatic at the time of attendance and disclosure. Discussion With changes to access due to ongoing COVID-19 restrictions, asymptomatic survivors may not receive opportunities to disclose as they are directed to online platforms. Healthcare services must adapt routine enquiry practices to ensure safe disclosure is possible to make all contacts count and expand these practices into other healthcare specialities to provide further disclosure opportunities for survivors not attending sexual health services.
Intergenerational Pathways Linking Mothers’ Adverse Childhood Experiences and Children’s Social-Emotional Problems
Authors: Zhang Lixia , Mersky Joshua P. , Lee Chienti P. 
Published: January 2022

Despite the persistent hypothesis that adverse childhood experiences (ACE) have intergenerational implications, empirical research documenting the effects and the mechanisms of transmission remains underdeveloped. This study examined the intergenerational effects of mothers’ adverse childhood experiences on their offspring’s social-emotional development and whether the association was mediated by mothers’ mental health, adult adversity, and perceptions of paternal involvement. The study sample included 831 mothers (19–49 years old, 47.5% White) with children aged 12–48 months who participated in a longitudinal investigation of low-income families in Wisconsin. ACEs were assessed by home visitors, and two waves of survey data were collected by researchers to assess demographics, mediators, and social-emotional outcomes. A path analysis showed that the association between maternal ACEs and children’s social-emotional problems was fully mediated, with postpartum mental health acting as a primary mechanism. Implications for intervention and future research directions are discussed.
Transient fetal intrathoracic cyst first detected during the 11- to 13-week scan: A resolving pericardial cyst?
Authors: Sepulveda Waldo , Stuardo Patricio 
Published: January 2022

Introduction: The prenatal detection of an intrathoracic cyst during the first trimester of pregnancy is an exceedingly rare condition. In this report, we describe a case of first-trimester intrathoracic cyst causing cardiac dextroposition, which resolved by 24 weeks’ gestation. Case report: A 5-mm intrathoracic cyst causing cardiac dextroposition was detected during the routine sonographic scan performed at 12 weeks + 2 days. The cyst remained stable in size until 20 weeks and was no longer identified during focused fetal echocardiography at 24 weeks. Discussion: Our case demonstrates that a first-trimester intrathoracic cyst can have a benign course, either by remaining stable in size or even undergoing complete resolution during the second trimester. A focused sonographic examination should therefore be undertaken as follow-up to determine the final prognosis of these lesions. Conclusion: The etiology of intrathoracic cysts detected in the first trimester is unclear and could represent a resolving pericardial cyst.