bluuebunny/crossref_metadata_2025_split huggingface dataset:
The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases
Authors: Ilani Tal , Reznik Nava , Yeshaya Noa , Feldman Tal , Vilela Patrick , Lansky Zipora , Javitt Gabriel , Shemesh Michal , Brenner Ori , Elkis Yoav , Varsano Neta , Jaramillo Ana M , Evans Christopher M , Fass Deborah 
Published: October 2022

AbstractMucus is made of enormous mucin glycoproteins that polymerize by disulfide crosslinking in the Golgi apparatus. QSOX1 is a catalyst of disulfide bond formation localized to the Golgi. Both QSOX1 and mucins are highly expressed in goblet cells of mucosal tissues, leading to the hypothesis that QSOX1 catalyzes disulfide‐mediated mucin polymerization. We found that knockout mice lacking QSOX1 had impaired mucus barrier function due to production of defective mucus. However, an investigation on the molecular level revealed normal disulfide‐mediated polymerization of mucins and related glycoproteins. Instead, we detected a drastic decrease in sialic acid in the gut mucus glycome of the QSOX1 knockout mice, leading to the discovery that QSOX1 forms regulatory disulfides in Golgi glycosyltransferases. Sialylation defects in the colon are known to cause colitis in humans. Here we show that QSOX1 redox control of sialylation is essential for maintaining mucosal function.
“It is the Wild West out here”
Authors: Magnan André , Wendimu Mengistu , Desmarais Annette , Aske Katherine 
Published: October 2022

This research builds on the emerging body of literature investigating the implications of changing land tenure relations in the Prairie Provinces, where over 70% of Canada’s farmland is located. Through an analysis of survey data collected in 2019 from 400 grain farmers, we address the following research questions: How are farmers experiencing changing patterns of land tenure and control at the local level? What challenges and opportunities do farmers face in these changing farmland markets? And, how has the entry of new actors (farmland investors) changed relationships between landlords and tenants? Our findings suggest that those farmers who are witnessing the financialization of farmland in their regions view this phenomenon with alarm. Furthermore, we show that those who rent from corporate investors are more often subject to landlord influence over production practices and pay higher rental rates than those who rent from other landlord types. Concern about farmland concentration is widespread among Prairie farmers, with a variety of negative effects identified, including increased competition over land and the decline of local communities. We recommend that future research probe how different investor types (individual vs. corporate and/or institutional) engage in land markets, examine the gender dimensions of landlord-tenant relations, and engage in analyses that challenge the current iteration of the private property regime.
Momentum is building for a school food program for Canada
Authors: Webb Carolyn , Field Debbie 
Published: October 2022

We’re at a tipping point towards our goal of ensuring that all children and youth can access healthy food at school. With momentum building for a Canada-wide school food program, and with many provinces and territories making their own investments and developing programs, we have a collective and unprecedented opportunity to influence the design and direction of school food programs, policy and funding for Canada and impact the lives of children and communities across the country.
The Coalition for Healthy School Food is very excited to welcome this edition of the Canadian Association for Food Studies Journal, which includes four articles on the issue of youth and food. We’re so pleased to see research on this theme that will inform the development of school food initiatives across the country.
CFD modeling of a rain event on combined sewer overflow
Authors: Šutúš Marek , Škultétyová Ivona , Marko Ivana , Wittmanová Réka , Stanko Štefan 
Published: October 2022

Abstract
Stretching periods between precipitations have been recorded, and an adjustment of the dispersion of rainfall over the long run could be seen. An expanded number of these peculiarities have additionally been affirmed by the international panel on climate change. Due to this adjustment of the reallocation of water and the effect of high urbanization, the sewerage frameworks are affected. The aim of the work was to compare simulations of the rain event on the combined sewer overflow due to the reduced water quality recorded in the Trnávka River. The current state and the proposed building modification were compared because the current hydraulic and construction modification of the combined sewer overflow is absolutely not corresponding to the environmental regulations.
El dolor: condicionamiento y valoración en la persona
Authors: Vilar i Planas de Farnés Joan 
Published: October 2022

INTRODUCCIÓN: el fondo vital y endotímico en el todo personal.

I. PLASMACIÓN DEL DOLOR EN JESUCRISTO.
- El dolor 19 siglos después. Respuesta personal ante el dolor ajeno.

II. PRINCIPIOS PARA UNA TERAPÉUTICA.
- Un dolor del que no conviene prescindir.
- Dolores que el hombre puede someter.
- Dolores incurables.
- Fantasía y sufrimiento.
COMO NOS COMUNICAMOS (SOBRE LINGUÍSTICA) IMPORTA: BATE-PAPO COM JANAISA VISCARDI
Authors: Oliveira Helio , Viscardi Janaisa M 
Published: October 2022

Neste texto, a linguista e produtora de conteúdo Janaisa Viscardi fala de suas experiências como pioneira na divulgação científica da Linguística no Brasil, tanto no YouTube, onde mantém um canal há 7 anos, quanto em outras plataformas e redes sociais, com implicações específicas sobre diferentes públicos, formatos e gêneros discursivos nos quais questões sobre língua, linguagem e linguística são tratadas de forma acessível ao público em geral.
Extending Monitoring Area of Production Plant Using Synchronized Relay Node Message Scheduling
Authors: Perdana Doan , Dewanta Favian , Wibawa Ig Prasetya Dwi 
Published: October 2022

Abstract—Low rate wireless sensor network has been used in industrial plant for certain production monitorings which have slow production rate. In the case of adding production line in the different building within one factory area, relay nodes are needed to increase monitoring coverage and connectivity among all nodes in the plant area. This paper presents the performance of relay node message scheduling scheme for extending monitoring area of production plan by using low rate wireless sensor network. The simulation results demonstrate that the distance and number of hop from certain relay nodes to the sink affect message end to end delay. Furthermore, increasing message rate generated by relay nodes also contributes in leveraging end to end delay of each message due to increasing queueing delay.
Vulnerabilidades ambientais do Bioma Cerrado: Estudo da região Norte Goiano - Goiás.
Authors: Santos Matheus Bleza , Faria Karla Maria Silva 
Published: October 2022

O processo de ocupação de Goiás ocorreu associado à expansão da fronteira agrícola, que restringiu a vegetação remanescente às áreas com limitações físicas e/ou legalmente protegidas, mas que recentemente encontram-se sob pressão para ocupação. O objetivo do trabalho foi o de avaliar a vulnerabilidade da região norte de Goiás, considerando variáveis como incêndios e perda de solo. Constatou-se riscos elevados à ocupação antrópica com prejuízos a conservação da biodiversidade, sendo eles:
fragmentação ambiental, migração de animais para outras regiões em decorrência do fogo, além da perca de baixa produtividade econômico em certas regiões. Nesse sentido, o estudo por microrregião destacou a fragilidade ambiental da Microrregião de Porangatu que não apresenta quaisquer áreas de proteção e cuja pressão antrópica é elevada. Ressalta-se a forte vulnerabilidade ambiental da Microrregião da Chapada dos Veadeiros, porém nela se encontra o Parque Nacional Chapada dos Veadeiros (PNCV) o qual recentemente obteve um ganho em sua área.
Occupational injuries and hand - An experience of 182 cases
Authors: Mashalkar Narendra S , Shetty Naren 
Published: October 2022

To observe the demography of hand bone fractures and the surgical procedure outcome and to observe the anatomical site of individual metacarpal and phalangeal fractures with machine related injuries.: This is a retrospective record analysis of 182 cases of hand bone fractures associated with occupational related injuries.: Records of traumatic hand bone fractures irrespective of age and sex referred from the emergency dept were reviewed .The records of pure soft tissue injuries of hand and burns were excluded. Data were analyzed and projected in the form of tables and figures. : Cross tabulation for the entire pattern was done, due to many variables statistical significant analysis could not be derived.: There were total 182 cases of which (90%) males, (9%) females and 2 cases where gender was not mentioned. Most of the age group were young adults (15 to 25yrs) with machine contact related injuries. Of machine related injuries, 29% had cutting machine injuries followed by press punching machine (27%). The most common phalanx involved in all categories of occupational injuries was distal phalanx.: Most of the hand bone fractures were noted in the right hand of young males with compound fracture of distal phalanx being more commonly involved; most of them had multiple finger involvement.Cutting and press punching machines caused severe crush injuries, ending up in high number of revision amputation than concrete mixer and heavy objects fall on hand. Hence extra care and safety features with supervision by experts are required while operating these types of machines.Shaft of metacarpal and proximal phalangeal fracture were more commonly involved as per individual site analysis.
Current strategies for targeted therapy of liver fibrosis
Authors: Garbuzenko D. V. 
Published: October 2022

Liver fibrosis (LF) is an unfavorable event in the natural course of chronic liver diseases (CLD), therefore, early implementation and widespread use of antifibrotic therapy methods is a pressing issue in hepatology. The aim of the review was to describe current approaches to targeted therapy of LF.PubMed database, Google Scholar search engine, Cochrane Database of Systematic Reviews, eLIBRARY.RU scientific electronic library, as well as reference lists of articles were used to search for scientific articles. The publications that corresponded to the aim of the study were selected for the period from 1998 to 2021 by the terms “liver fibrosis”, “pathogenesis”, and “treatment”. Inclusion criteria were restricted to targeted therapy of LF.Despite the growing evidence for reversibility of LF, there are currently no effective or clinically approved regimens for its specific therapy. However, taking into account the relevance of the issue, scientific research in this area is necessary. Multiple drugs with a good safety profile have been studied, which, though intended for other purposes, can have a positive effect on LF. In addition, a number of innovative approaches that differ from pharmacotherapy inspire optimism about finding a solution to this problem. It is obvious that studies focused on well-characterized groups of patients with confirmed histologic, elastography, clinical, and radiological parameters are required. This is a challenging task, since the key point will be stratification of risk based on ethnicity, etiology, and clinical status, and very large samples will be required for a reliable assessment. Nevertheless, the solution will increase efficiency of treatment for patients with CLD, improve their prognosis and quality of life, and significantly reduce the need for liver transplantation, a demand for which remains extremely high worldwide.
The role of cathepsin S in the pathophysiology of bronchial asthma
Authors: Kraposhina A. Yu. , Sobko E. А. , Demko I. V. , Kazmerchuk O. V. , Kacer A. B. , Abramov Yu. I. 
Published: October 2022

To date, the study of the role of proteases in the pathogenesis of various diseases remains relevant. The variety of cathepsin functions is associated with the peculiarities of their localization, expression, and regulation, due to which cathepsins are involved in development of many pathologies. Dysregulation of proteases, their inhibitors, and substrates can lead to the development of multiple organ dysfunction.The review presents data on the characteristics of the entire family of cathepsins and cathepsin S, in particular. The pathophysiological role of cathepsin S in the formation of bronchopulmonary pathologies, as well as in bronchial asthma is described, and intraand extracellular implementation mechanisms are considered. The authors believe it is this enzyme that could be targeted in targeted asthma therapy to prevent airway wall remodeling at the earliest stages of the disease. The literature search was carried out in the search engines Medline, eLibrary, Scopus, the Cochrane Library, and RSCI.
Expression of inhibitory receptors PD-1, CTLA-4, and Tim-3 by peripheral T cells during pregnancy
Authors: Smetanenko E. A. , Khonina N. A. , Leplina O. Yu. , Tikhonova M. A. , Batorov E. V. , Pasman N. M. , Chernykh E. R. 
Published: October 2022

Background. Inhibitory receptors and their ligands (also called checkpoint molecules) are important feedback regulators of the immune response. However, their role in immunological adaptation during pregnancy remains poorly understood.The aim of the study was to evaluate the level of checkpoint molecule (PD-1, CTLA-4, Tim-3) expression in peripheral T cells in pregnant women compared with fertile non-pregnant women.Materials and methods. The study included 36 women in the second half of pregnancy without pregnancy complications, 12 of whom had extragenital pathology. The control group consisted of 28 age-matched fertile non-pregnant women. The proportion of CD8+PD-1+, CD8+TIM-3+, CD8+PD-1+TIM-3+, CD4+PD-1+, CD4+TIM-3+, and CD4+PD-1+TIM-3+ was evaluated by flow cytometry using the corresponding monoclonal antibodies (BD Biosciences, USA).Results. The proportion of CD4+Tim-3+ and CD8+PD-1+ Т cells and CD4+ and CD8+ Т lymphocytes co-expressing PD-1 and Tim-3 in the peripheral blood of pregnant women was statistically significantly higher than in non-pregnant women. An increase in CD4+Tim-3+ and CD8+PD-1+ T cells was observed both in pregnant women with and without extragenital pathology. However, pregnant women with extragenital pathology were characterized by a higher CD8+PD-1+ count and a smaller number of CD8+Tim-3+ cells, as well as by a lack of an increase in PD-1+Tim-3+ T cells typical of pregnant women. The number of comorbidities was directly correlated with the proportion of CD8+PD-1+ lymphocytes and inversely correlated with the proportion of CD8+Tim-3+ and CD4+ PD-1+Tim-3+ cells. In addition, the expression of checkpoint molecules was associated with gestational age (a direct correlation was found with the proportion of CD8+Tim-3+, CD4+PD-1+Tim-3+, and CD8+PD-1+Tim-3+ cells) and to a lesser extent – with the age of pregnant women (an inverse relationship was found with the proportion of CD8+Tim-3+ cells).Conclusion. Pregnant women in the second half of pregnancy are characterized by increased expression of PD-1 and Tim-3 molecules in peripheral T cells. At the same time, concomitant extragenital pathology affects the expression of these molecules.
Novel Design of a Sentiment Based Stock Market Index Forecasting System
Authors: Roy Partha 
Published: October 2022

Abstract

This article proposes a novel idea for creating a sentiment-based stock market index forecasting model by amalgamating price and sentiment data. The design guidelines are provided using which researchers can explore and create prediction or expert systems that can help in profitably trading the stock markets. A modular design approach is proposed for developing the prediction system. The article demonstrates steps using which the prediction system model can be built. A prototype of the model is also been developed whose performance results are provided. It is observed that there is an ample avenue for improvements that can done by the researchers for tuning up the performance of the proposed model. The model performs a unique modification to the traditional tf-idf technique and converts it into a forecasting tool. The model is simple and easy to implement with very nominal memory requirements, compared to other types of models. Nifty-50 index values were used to analyze the performance of the proposed model. This model is being developed for research purposes only.
Activation of persulfate by lanthanum modified activated coke for tetracycline degradation
Authors: Li Guoting , Zhang Zhenzhen , Chen Huan , Li Kangli , Liu Yingxu , Guo Yiping , Guo Yujie , Pak Tannaz 
Published: October 2022

Abstract
Activated coke (ACO) has been applied in some wastewater treatment plants to advance the removal of micro-pollutants from secondary effluent. This work investigated the use of Lanthanum (La) to modify ACO (La-ACO) for enhancing the removal/degradation of micro-pollutants by activating peroxydisulfate (PDS). We report that the immobilization of La oxide on ACO significantly enhances the adsorption of tetracycline (TC) from aqueous solution as well as its persulfate-based catalytic oxidation. The pseudo-first-order Kapp value of the La-ACO/PDS process is 1.41 times that of adsorption and PDS oxidation alone, indicating an evident synergistic effect. Surface analysis confirms the introduction of La on ACO, while both La(OH)3 and La2O3 consist of La species on La-ACO. The pH values close to neutral are shown to improve the degradation of TC. Also, increasing reaction temperature improves the TC oxidation. The oxidizing species superoxide anion radical (O2·−) and active holes (h+) prove the predominant oxidizing species, while the contribution percentages of O2·− and h+ achieve 51.3% and 84.2% of the total degradation capacity, respectively. The inhibiting effect of SO42− and Cl− is insignificant, while the coexisting humic acid has actually improved the TC removal. Reusability test indicates the stable and continuable PDS catalytic ability.
Theoretical approach to classical reduced mass vector in the many-body problem and its application to vibrations of water
Authors: Abdel-Rahman Ahmed Sabry 
Published: October 2022

Abstract
Reduced mass value and vector are well known for two-body problem; the study of many-body problems and their applications (such as vibrational spectroscopy) is one of the important physical problems. Vibrational spectroscopy provides a powerful tool to perceive the molecular structures and atom motions of molecules. The water molecule is a three-body system stretching vibration that has been previously quantized, showing the infrared (IR) absorption spectrum based on Morse potential. In this work, the molecule was studied in classical and quantum mechanics to determine its absorption intensity. The results show molecular atomic motions and changes in dipole and reduced mass vector. A Morse-like model for bending was predicted based on the spectroscopic vibration frequency and intensity, defining the bending potential depth of 93.5 kJ/mol.
Workload Indicators of Staffing Need (WISN) Method for Health Workforce Planning at Health Facility: A scoping review
Authors: Asres Gizew Dessie , Gessesse Yeshiwork Kebede 
Published: October 2022

Abstract

Background
In the presence of diverse workforce planning method, identifying advantages, challenges and limitations of each method is very important. Population to health workforce ratio method faced challenges of continuous population growth and variations of health care needs over time. Standard staffing schedule was used to solve challenges of population ratio method but itself faced another challenge on how to distribute health workforces between health facilities with in a country. A workload indicator of staffing need (WISN) method was designed to alleviate challenges of the above mentioned methods. Challenges and limitations of WISN method have not been systematically reviewed and that is why this scoping review was designed
Methods
We conducted a scoping review of literatures with the objective of identifying implications, challenges and limitations of WISN method workforce planning at health facilities. Arksey and O’Malley’s methodological steps were followed to develop the research questions, identify relevant studies, include/ exclude studies, extract data, and report the findings. To ensure methodological quality PRISMA guideline and PRISMA- ScR checklist was used.
Results
A total of 27 studies were eligible and more than 83% were published between 2019 and 2022. Majority of studies used retrospective quantitative data with cross sectional study design but four studies incorporated qualitative parts too. The major challenges identified were health service activity standard of workload component, data quality or availability and technical details of the WISN itself. This review reveled WISN method limitations on precision of WISN result as it depends on last year record, service interruptions, time differences in completing clinical activity based on patient status and professional variations and over time health care activities.
Conclusion
WISN model of human resources for health planning adjusts workload pressure among health care workers within and between health facilities. Health care administrators or authorities use it for task shifting indicator within a health facility and equitable distribution indicator between health facilities. Being a very useful human resource planning tool, WISN has challenges and limitations too.
The journey to a Learning Health System in primary care: a qualitative case study utilising an embedded research approach
Authors: Dammery Genevieve , Ellis Louise A. , Churruca Kate , Mahadeva Janani , Lopez Francisco , Carrigan Ann , Halim Nicole , Willcock Simon , Braithwaite Jeffrey 
Published: October 2022

Abstract

Background Healthcare systems may be resilient and adaptive, but they are not fit for purpose in their current state. Increasing threats to health system sustainability have underscored the need to move towards a learning health system in which research and data are used routinely in clinical practice to facilitate system improvement. This study aimed to evaluate a university-based general practice to establish which elements of the learning health system were being realised within the practice and determine acceptability from staff to embrace further transition towards a learning health system. Methods Semi-structured interviews were conducted with practice staff, including clinical and administrative staff, to determine the current state of the learning health system in the practice. An embedded researcher was placed within the general practice on a part-time basis to investigate the LHS model. Interviews were transcribed and thematically analysed using a framework approach. Results In total, 32 (91%) practice staff were interviewed, comprising general practitioners (n = 15), nurses (n = 3), administrative staff (n = 13), and a psychologist (n = 1). Participants indicated that the practice was operating with several characteristics of a learning health system, supported by the university-based setting, and resultant culture of learning. Nevertheless, there were still areas of the practice where the learning health system could be strengthened, specifically relating to the use of patient data and informatics. Staff generally expressed willingness to engage with the process of strengthening the learning health system within their practice. Conclusion Although the idea of a learning health system has been gaining traction in recent years, there are still comparatively few empirical studies presented in the literature. This research presents a case study of a general practice that is operating as a learning health system and highlights the utility of using the learning health system framework.