bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract PD5-09: Work status changes and associated factors in a nation-wide sample of 1324 Norwegian long-term breast cancer survivors
Authors: Bøhn Synne-Kristin Hoffart , Vandraas Kathrine , Kiserud Cecilie E , Dahl Alv A , Ewertz Marianne , Lie Hanne Cathrine , Falk Ragnhild , Reinertsen Kristin Valborg 
Published: March 2022

Abstract
Background: Little is known about work participation in breast cancer survivors (BCSs) beyond two years after diagnosis. This study aims to report work status at diagnosis and at eight years post-diagnosis in a nation-wide sample of BCSs, investigate factors associated with reduced work status, and report on self-perceived reasons for reduced work status or disability pension. Material and Methods: Women diagnosed with stage I-III BC at the age of 20-65 years in 2011 or 2012 were invited to participate (n=2,803), of which 49 % (n=1361) responded. The response rate was 49 % (n=1361). A final sample of 1324 BCSs with complete questionnaire information regarding work status were included in the present study. Logistic regression analyses were applied to identify factors associated with reduced work status. Results At diagnosis, 78% (n=1038) of the BCSs were in paid work, 12% received disability pension and 4 % held early retirement. At survey, 42% of the BCSs were in paid work, 26% held disability pension and 28% were retired. Of the 845 survivors who were in paid work at diagnosis and within working age at survey, 63% maintained their work status, while 37% reduced their work status. Living with children (OR 0.4, p=.007), older age (OR 1.2, p&lt;.001), chemotherapy (OR 2.9, p=.013), three or more comorbid conditions (OR 2.2, p=.016), higher level of fatigue (OR 1.02, p&lt;.001), symptoms of cognitive dysfunction (OR 0.9, p=.038) and higher degree of neuroticism (OR 1.2, p=.012) were associated with reduced work status. BC, complaints and late effects after BC were reported as the main or partial reason for reduced work status and disability. Conclusion Almost two thirds of BCSs in working age who were in paid work at diagnosis remained in the paid work force eight years later. Individual characteristics and various health complaints including fatigue end cognitive dysfunction were associated with reduced work status from diagnosis to survey. Evaluation and treatment of these conditions are warranted, with the ultimate aim of improving work maintenance in long-term BCSs.
Citation Format: Synne-Kristin Hoffart Bøhn, Kathrine Vandraas, Cecilie E Kiserud, Alv A Dahl, Marianne Ewertz, Hanne Cathrine Lie, Ragnhild Falk, Kristin Valborg Reinertsen. Work status changes and associated factors in a nation-wide sample of 1324 Norwegian long-term breast cancer survivors [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr PD5-09.
Targeting Metabolic Adaptations in the Breast Cancer–Liver Metastatic Niche Using Dietary Approaches to Improve Endocrine Therapy Efficacy
Authors: Zuo Qianying , Mogol Ayca Nazli , Liu Yu-Jeh , Santaliz Casiano Ashlie , Chien Christine , Drnevich Jenny , Imir Ozan Berk , Kulkoyluoglu-Cotul Eylem , Park Nicole Hwajin , Shapiro David J. , Park Ben Ho , Ziegler Yvonne , Katzenellenbogen Benita S. , Aranda Evelyn , O'Neill John D. , Raghavendra Akshara Singareeka , Tripathy Debu , Madak Erdogan Zeynep 
Published: March 2022

Abstract

Estrogen receptor–positive (ER+) metastatic tumors contribute to nearly 70% of breast cancer–related deaths. Most patients with ER+ metastatic breast cancer (MBC) undergo treatment with the estrogen receptor antagonist fulvestrant as standard of care. Yet, among such patients, metastasis in liver is associated with reduced overall survival compared with other metastasis sites. The factors underlying the reduced responsiveness of liver metastases to ER-targeting agents remain unknown, impeding the development of more effective treatment approaches to improve outcomes for patients with ER+ liver metastases. We therefore evaluated site-specific changes in MBC cells and determined the mechanisms through which the liver metastatic niche specifically influences ER+ tumor metabolism and drug resistance. We characterized ER activity of MBC cells both in vitro, using a novel system of tissue-specific extracellular matrix hydrogels representing the stroma of ER+ tumor metastatic sites (liver, lung, and bone), and in vivo, in liver and lung metastasis mouse models. ER+ metastatic liver tumors and MBC cells grown in liver hydrogels displayed upregulated expression of glucose metabolism enzymes in response to fulvestrant. Furthermore, differential ER± activity, but not expression, was detected in liver hydrogels. In vivo, increased glucose metabolism led to increased glycogen deposition in liver metastatic tumors, while a fasting-mimicking diet increased efficacy of fulvestrant treatment to reduce the metastatic burden. Our findings identify a novel mechanism of endocrine resistance driven by the liver tumor microenvironment.

Implications:
These results may guide the development of dietary strategies to circumvent drug resistance in liver metastasis, with potential applicability in other metastatic diseases.
Watch the interview with Zeynep Madak-Erdogan, PhD, recipient of the 2024 MCR Michael B. Kastan Award for Research Excellence: https://vimeo.com/992993791
IDH1 Inhibition Reawakens the Immune Response against Cholangiocarcinoma
Authors: Zhu Yan , Kwong Lawrence N. 
Published: March 2022

Summary:
Isocitrate dehydrogenase 1 mutations (mIDH1) are common in cholangiocarcinoma, but their exact mechanisms in cholangiocarcinoma initiation and maintenance are unclear. In this issue of Cancer Discovery, Wu and colleagues identify immune suppression via TET2 inactivation as the primary means by which mIDH1 maintains cholangiocarcinoma survival, leading to an efficacious new combination of mIDH1 inhibitors and immune checkpoint blockade targeting regulatory T cells.
See related article by Wu et al., p. 812 (9).
Challenges of Neural Machine Translation for Short Texts
Authors: Wan Yu , Yang Baosong , Wong Derek Fai , Chao Lidia Sam , Yao Liang , Zhang Haibo , Chen Boxing 
Published: March 2022

Abstract
Short texts (STs) present in a variety of scenarios, including query, dialog, and entity names. Most of the exciting studies in neural machine translation (NMT) are focused on tackling open problems concerning long sentences rather than short ones. The intuition behind is that, with respect to human learning and processing, short sequences are generally regarded as easy examples. In this article, we first dispel this speculation via conducting preliminary experiments, showing that the conventional state-of-the-art NMT approach, namely, Transformer (Vaswani et al. 2017), still suffers from over-translation and mistranslation errors over STs. After empirically investigating the rationale behind this, we summarize two challenges in NMT for STs associated with translation error types above, respectively: (1) the imbalanced length distribution in training set intensifies model inference calibration over STs, leading to more over-translation cases on STs; and (2) the lack of contextual information forces NMT to have higher data uncertainty on short sentences, and thus NMT model is troubled by considerable mistranslation errors. Some existing approaches, like balancing data distribution for training (e.g., data upsampling) and complementing contextual information (e.g., introducing translation memory) can alleviate the translation issues in NMT for STs. We encourage researchers to investigate other challenges in NMT for STs, thus reducing ST translation errors and enhancing translation quality.
Assessing Corpus Evidence for Formal and Psycholinguistic Constraints on Nonprojectivity
Authors: Yadav Himanshu , Husain Samar , Futrell Richard 
Published: March 2022

Abstract
Formal constraints on crossing dependencies have played a large role in research on the formal complexity of natural language grammars and parsing. Here we ask whether the apparent evidence for constraints on crossing dependencies in treebanks might arise because of independent constraints on trees, such as low arity and dependency length minimization. We address this question using two sets of experiments. In Experiment 1, we compare the distribution of formal properties of crossing dependencies, such as gap degree, between real trees and baseline trees matched for rate of crossing dependencies and various other properties. In Experiment 2, we model whether two dependencies cross, given certain psycholinguistic properties of the dependencies. We find surprisingly weak evidence for constraints originating from the mild context-sensitivity literature (gap degree and well-nestedness) beyond what can be explained by constraints on rate of crossing dependencies, topological properties of the trees, and dependency length. However, measures that have emerged from the parsing literature (e.g., edge degree, end-point crossings, and heads’ depth difference) differ strongly between real and random trees. Modeling results show that cognitive metrics relating to information locality and working-memory limitations affect whether two dependencies cross or not, but they do not fully explain the distribution of crossing dependencies in natural languages. Together these results suggest that crossing constraints are better characterized by processing pressures than by mildly context-sensitive constraints.
On the Road: Poor Travelers in Mid-Seventeenth-Century Friesland
Authors: de Vries Jan 
Published: March 2022

Abstract
Outsiders—some traveling to a possible place of employment or refuge and some wandering as vagabonds with an eye on the main chance—were a constant presence in early modern Europe. But their stories are faint to nonexistent in most of the archival records available to historians. Such records illuminate the lives of the permanent, rooted, populations but rarely reveal much about those who stood outside the local communities through which they passed on their journeys. Analysis of a large, unusual data set compiled in the small Dutch city of Franeker in the mid-seventeenth century, however, uncovers the circumstances and motives of poor travelers and indigent wayfarers who passed through the city, providing a glimpse into the lives of a population otherwise largely hidden.
Assembling Path Dependency and History: An Actor-Network Approach
Authors: De Munck Bert 
Published: March 2022

Abstract
Historians and social scientists struggling to redefine the relationship between synchrony (structure) and diachrony (events and human agency) have recently turned to the notion of path dependence, the core idea of which is that history matters. But history and path-dependence theory have less in common than might appear at first glance. Actor-network theory (ant) helps to bridge the gap between history and path dependence by incorporating the complex, layered, open, and hybrid nature of interlocked economic, symbolic, institutional-political, and socio-technical systems.
Shared Attention Amplifies the Neural Processing of Emotional Faces
Authors: Schiano Lomoriello Arianna , Sessa Paola , Doro Mattia , Konvalinka Ivana 
Published: March 2022

Abstract
Sharing an experience, without communicating, affects people's subjective perception of the experience, often by intensifying it. We investigated the neural mechanisms underlying shared attention by implementing an EEG study where participants attended to and rated the intensity of emotional faces, simultaneously or independently. Participants performed the task in three experimental conditions: (a) alone; (b) simultaneously next to each other in pairs, without receiving feedback of the other's responses (shared without feedback); and (c) simultaneously while receiving the feedback (shared with feedback). We focused on two face-sensitive ERP components: The amplitude of the N170 was greater in the “shared with feedback” condition compared to the alone condition, reflecting a top–down effect of shared attention on the structural encoding of faces, whereas the EPN was greater in both shared context conditions compared to the alone condition, reflecting an enhanced attention allocation in the processing of emotional content of faces, modulated by the social context. Taken together, these results suggest that shared attention amplifies the neural processing of faces, regardless of the valence of facial expressions.
Neural Activity during Story Listening Is Synchronized across Individuals Despite Acoustic Masking
Authors: Irsik Vanessa C. , Johnsrude Ingrid S. , Herrmann Björn 
Published: March 2022

Abstract
Older people with hearing problems often experience difficulties understanding speech in the presence of background sound. As a result, they may disengage in social situations, which has been associated with negative psychosocial health outcomes. Measuring listening (dis)engagement during challenging listening situations has received little attention thus far. We recruit young, normal-hearing human adults (both sexes) and investigate how speech intelligibility and engagement during naturalistic story listening is affected by the level of acoustic masking (12-talker babble) at different signal-to-noise ratios (SNRs). In , we observed that word-report scores were above 80% for all but the lowest SNR (−3 dB SNR) we tested, at which performance dropped to 54%. In , we calculated intersubject correlation (ISC) using EEG data to identify dynamic spatial patterns of shared neural activity evoked by the stories. ISC has been used as a neural measure of participants' engagement with naturalistic materials. Our results show that ISC was stable across all but the lowest SNRs, despite reduced speech intelligibility. Comparing ISC and intelligibility demonstrated that word-report performance declined more strongly with decreasing SNR compared to ISC. Our measure of neural engagement suggests that individuals remain engaged in story listening despite missing words because of background noise. Our work provides a potentially fruitful approach to investigate listener engagement with naturalistic, spoken stories that may be used to investigate (dis)engagement in older adults with hearing impairment.
Alpha and Theta Bands Dynamics Serve Distinct Functions during Perception–Action Integration in Response Inhibition
Authors: Prochnow Astrid , Eggert Elena , Münchau Alexander , Mückschel Moritz , Beste Christian 
Published: March 2022

Abstract
The ability to inhibit responses is central for situational behavior. However, the mechanisms how sensory information is used to inform inhibitory control processes are incompletely understood. In the current study, we examined neurophysiological processes of perception–action integration in response inhibition using the theory of event coding as a conceptual framework. Based on theoretical considerations, we focused on theta and alpha band activity in close connection to the functional neuroanatomical level using EEG beamforming. Moreover, we performed a network-based analysis of theta and alpha band activity. We show a seesaw-like relationship between medial and superior frontal cortex theta band activity and frontoparietal cortex alpha band activity during perception–action integration in response inhibition, depending on the necessity to reconfigure perception–action associations. When perception–action integration was more demanding, because perception–action associations (bindings) have to be reconfigured, there was an increase of theta and a decrease of alpha band activity. Vice versa, when there was no need to reconfigure perception–action bindings, theta band activity was low and alpha band activity was high. However, theta band processes seem to be most important for perception–action integration in response inhibition, because only the sensor-level network organization of theta band activity showed variations depending on the necessity to reconfigure perception–action associations. When no reconfiguration was necessary, the network architecture was more small-world-like, likely enabling efficient processing. When reconfigurations were necessary, the network organization becomes more random. These differences were particularly strong for fractions of the neurophysiological signal supposed to reflect response selection processes.
Jamesian Ethics: A Working Model
Authors: Throntveit Trygve 
Published: March 2022

Abstract
In this essay I respond to critical readers of my book, William James and the Quest for an Ethical Republic. I argue that James’s ultimate preoccupations are ethical, and that his ethical and moral writings constitute a rich resource for pluralistic societies seeking democratic tools for negotiating deep ideological, cultural, and religious differences, and for building a thriving commons.
Christian Fundamentalism in Japan
Authors: Ruotsila Markku 
Published: March 2022

Abstract
This article examines the ultimately unfruitful attempts by U.S. Christian fundamentalists at establishing a presence within Japanese Protestantism. Almost unknown even to scholars in the field, this missionary effort was launched in 1949. It yielded several indigenous institutions, including the Tokyo Christian Theological Seminary, the Japan Bible Times, and the Christian Presbyterian Church of Japan. This uniquely American import of a fundamentalist defense of the “faith once received” is here put in regional, anti-communist and intercultural contexts.
Blunt head trauma in a peculiar case of partial mummification. Murder or accidental event?
Authors: Barranco Rosario , Castelletti Lara , Fossati Francesca , Zotti Mirca , Orcioni Giulio Fraternali , Verdiani Simonetta , Ventura Francesco 
Published: March 2022

The finding of a partially mummified body presenting signs of trauma requires the forensic pathologist to conduct a careful and complex examination; multidisciplinary analysis is often necessary. We report a case where the partially mummified corpse of an elderly man was found in his own home more than seven years after death. Complete post-mortem investigation revealed a cranial fracture and an acute subdural haematoma. An in-depth multidisciplinary analysis provided important information on the modality and cause of death but it was not possible to establish whether the trauma and death resulted from an accidental event or from an assault.
Race and Ethnicity in Otolaryngology Academic Publications
Authors: Lindeborg Michael , Din Taseer , Araya‐Quezada Cristóbal , Lawal Sabreena , Heer Baveena , Rajaguru Praveen , Joseph Myriam , Alkire Blake , Fagan Johannes 
Published: March 2022

ObjectiveWithin otolaryngology, race is commonly included as a study covariate; however, its value in clinical practice is unclear. This study sought to explore how race and ethnicity have been used and applied over time in otolaryngology publications.Data SourcesPubMed database.Review MethodsA systematic review was done to identify original otolaryngology studies between January 1, 1946, and June 25, 2020, with the following search terms: “otolaryngology” AND “race” OR “ethnicity.”ResultsOf the 1984 yielded studies, 932 were included in the final analysis. Only 2 studies (0.2%) defined race, and 172 (18.5%) gave participants the opportunity to self‐identify race. Less than half (n = 322, 43.8%) of studies controlled for confounders. One hundred studies (10.7%) linked race to genetic factors. An overall 564 (60.5%) made conclusions about race, and 232 (24.9%) mentioned that race is relevant for clinical decision making. The majority of studies had first and senior authors from high‐income countries (93.9% and 93.8%, respectively). Over time, there was a significant increase in publications that controlled for confounders, the number of race categories used, and studies that highlighted disparities.ConclusionRace and ethnicity are often poorly defined in otolaryngology publications. Furthermore, publications do not always control for confounding variables or allow participants to self‐identify race. On the basis of our findings, we suggest 7 foundational principles that can be used to promote equitable research in otolaryngology publications. Future efforts should focus on incorporating research guidelines for race and ethnicity into journal publication standards.
Diné (Navajo) Female Perspectives on Mother–Daughter Cultural Assets Around the Transition to Womanhood: A Qualitative Study
Authors: Richards Jennifer , Bueno Yvonne , Begay Jaime , Chambers Rachel Strom , Tingey Lauren , Teufel-Shone Nicolette , Kahn-John Michelle 
Published: March 2022

Introduction: American Indian (AI) people have protective factors embedded in cultural teachings that buffer against high-risk behaviors. This study applies a qualitative, grounded theory approach to identify cultural assets for a Diné (Navajo) mother-daughter intervention aimed at preventing substance abuse and teen pregnancy. Method: Focus groups and in-depth interviews were conducted with 28 AI females’ ages 8 years and older from the Navajo Nation. Results: Key themes were (a) preserving the Diné way of life, (b) cultural assets related to being a healthy Diné woman, (c) matrilineal networks as a source of strength/pride, (d) historical trauma as a source of resilience, (e) male influences as protective health factors, (f) Western education as a measure of success, and (g) integrating different belief systems. Discussion: Study findings may be applied as foundational elements for culturally grounded AI substance abuse and teen pregnancy prevention strategies, as well as culturally safe nursing practice.
Detecting Changes in Tissue Perfusion With Hyperspectral Imaging and Thermal Imaging Following Endovascular Treatment for Peripheral Arterial Disease
Authors: Kleiss Simone F. , Ma Kirsten F. , El Moumni Mostafa , Ünlü Çagdas , Nijboer Thomas S. , Schuurmann Richte C. L. , Bokkers Reinoud P. H. , de Vries Jean-Paul P. M. 
Published: March 2022

Purpose Hyperspectral imaging (HSI) and thermal imaging allow contact-free tissue perfusion measurements and may help determine the effect of endovascular treatment (EVT) in patients with peripheral arterial disease. This study aimed to detect changes in perfusion with HSI and thermal imaging peri-procedurally and determine whether these changes can identify limbs that show clinical improvement after 6 weeks. Methods Patients with Rutherford class 2–6 scheduled for EVT were included prospectively. Hyperspectral imaging and thermal imaging were performed directly before and after EVT. Images were taken from the lateral side of the calves and plantar side of the feet. Concentrations of (de)oxyhemoglobin, oxygen saturation, and skin temperature were recorded. Angiographic results were determined on completion angiogram. Clinical improvement 6 weeks after EVT was defined as a decrease ≥ one Rutherford class. Peri-procedural changes in perfusion parameters were compared between limbs with and without good angiographic results or clinical improvement. To identify limbs with clinical improvement, receiver operating characteristic (ROC) curves were used to determine cutoff values for change in HSI. Results Included were 23 patients with 29 treated limbs. Change in HSI values and temperature was not significantly different between limbs with good and poor angiographic results. Change in peri-procedural deoxyhemoglobin, determined by HSI, at the calves and feet was significantly different between limbs with and without clinical improvement at 6 week follow-up (p=0.027 and p=0.017, respectively). The ROC curve for change in deoxyhemoglobin at the calves showed a cutoff value of ≤1.0, and ≤−0.5 at the feet, which were discriminative for clinical improvement (sensitivity 77%; specificity 75% and sensitivity 62%; specificity 88%, respectively). Conclusions HSI can detect changes in perfusion at the calves after EVT in patients with Rutherford class 2–6. Peri-procedural deoxyhemoglobin changes at the calves and feet are significantly different between limbs with and without clinical improvement. Decrease in deoxyhemoglobin directly after EVT may identify limbs that show clinical improvement 6 weeks after EVT.