bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluid restriction management in the treatment of COVID-19: a single-center observational study
Authors: Matsumura Yosuke , Sugiyama Takuya , Kondo Natsuki , Miyahara Masaya , Hanaoka Noriyuki , Nagashima Hideaki , Kasahara Yuki , Fujiyoshi Naohiko , Inada Azusa , Inaba Shin 
Published: October 2022

AbstractThe relationship between fluid management and the severity of illness, duration of treatment, and outcome of coronavirus disease 2019 (COVID-19) is not fully understood. This study aimed to evaluate whether weight change during hospitalization was associated with COVID-19 severity, length of hospital stay, and route of admission. In this study, we assessed the effectiveness of fluid restriction management in patients with severe COVID-19. COVID-19 patients admitted to our hospital between July 2020 and October 2021 were analyzed. Patients were treated with standard drug therapy based on the Japanese guidelines and respiratory support according to the severity of the disease. Early enteral nutrition, defecation management, and anticoagulation therapy were also administered. Fluid restriction management was performed using furosemide and continuous renal replacement therapy as needed unless hemodynamic instability or hyperlactatemia was present. Patient background, route of admission (ambulance, A; transfer, T), weight at admission and discharge, the severity of illness (oxygen therapy, G1; mechanical ventilation, G2; extracorporeal membrane oxygenation, G3), in-hospital mortality, and length of hospital stay were analyzed. There were 116 subjects: G1 (n = 48), G2 (n = 43), and G3 (n = 25), with ages (median [IQR]) of 58 (47–70), 65 (53–71.5), 56 (51–62) years, 40 (83.3%), 31 (72.1%), and 19 (76.0%) males, respectively. Hospital stays were 4.5 (2–7), 10 (7–16), and 18 (15–26) days, and the in-hospital mortality rates were 0 (0%), 7 (16.3%), and 8 (32%), respectively. Body mass index on admission was 26 (23.1–30.2), 27.1 (22.7–31.1), and 31.5 (27.1–33.1) kg/m2, and weight loss during admission was 1.1 (0–2.9), 4.6 (2.3–5.7), 9.2 (5.6–10.5) kg (P < 0.001, Jonckheere–Terpstra test. Weight loss in the severe group (G2 + G3) was 3.4 (0.5–5.8) kg [A, n = 12] and 5.6 (4.4–9) kg [T, n = 43] [P = 0.026, Mann–Whitney U test]. The lengths of hospital stay were 5 (2–7), 9 (7–15), and 18 (12–26) days [P < 0.001, Jonckheere–Terpstra test]. In our fluid restriction management, patients with severe COVID-19 had significant longer hospital length of stay, weight loss, especially those who were transferred to the hospital.
Gesteigerte Therapiemotivation durch innovative Virtual-Reality-Therapie
Authors: Stemick Judith , Kurth Julia , Saur Thomas 
Published: October 2022

ZUSAMMENFASSUNGImmersive Virtuelle Realität (VR) bietet neue Möglichkeiten, die klassische Rehabilitation und Therapie zu ergänzen. Gerade im Bereich der Therapiemotivation kann eine gamifizierte virtuelle Umgebung den Patienten helfen, die benötigte Therapiefrequenz hochzuhalten. Eine Akzeptanzumfrage in der Stankt Mauritius Therapieklinik Meerbusch zeigte nach 200 ausgewerteten Therapiesitzungen mit dem System Cureo, dass 97 % der Patienten die VR-Therapie wiederholen würden. Nach Einschätzung der Therapeuten ist eine gesteigerte Therapiebereitschaft und Motivation bei 94,5 % der Patienten zu beobachten. 95,5 % der Patienten konnten die VR-Therapie nebenwirkungsfrei durchführen. Eine erfolgreiche Rehabilitation mittels VR-Therapie hängt zudem von einer idealen Integration in den klinischen Alltag ab. Dazu gehören gut geschultes Personal und eine passende Therapieumgebung. In dieser Arbeit werden 2 Beispiele aufgezeigt, zum einem in einem Krankenhaus in Berlin, zum anderen in einer niedergelassenen neurologischen Praxis.
Automatische Analyse motorischer Symptome zuhause
Authors: Schmidt Katharina , Mansow-Model Sebastian 
Published: October 2022

ZUSAMMENFASSUNGDie Beobachtung und Behandlung von motorischen Symptomen ist für das Wohlbefinden von Parkinson-Patienten von entscheidender Bedeutung. Unter Laborbedingungen lassen sich diese Symptome akkurat messen, in der Routineversorgung konnte sich aber keine praktikable Lösung mit ausreichender Messqualität etablieren. Motognosis Amsa ist eine auf 3D-Kameras basierende Messsoftware zum Einsatz durch Parkinson-Patienten zuhause und könnte diese Lücke schließen. Die Validierung von Genauigkeit, klinischer Aussagekraft und Nutzbarkeit verlief positiv, Daten zur Langzeitnutzung werden erhoben.
Von Anämie bis Zuckerkrankheit
Authors: Galliardt Melanie , Betz Ulrich , Geber Christian 
Published: October 2022

ZUSAMMENFASSUNGMenschen stürzen im Alter aus verschiedenen Gründen. Einfluss nehmen zum Beispiel das Geschlecht, kognitive Fähigkeiten oder das Schuhwerk. Für Therapierende gilt es die Risikofaktoren für einen Sturz zu erfassen und herauszufinden, welche Interventionsmöglichkeiten in Frage kommen.
Digitale Unterstützung in Diagnose und Management von Parkinsonerkrankungen
Authors: Henze Jasmin , Bisgin Pinar , Burmann Anja , Haubrich Christina 
Published: October 2022

ZUSAMMENFASSUNGZur Unterstützung der Früherkennung, Diagnose und Begleitung der Parkinson-Erkrankung wurde der ParkinsonCompanion entwickelt. Ziel des Systems ist es, erstmals nicht motorische Symptome der Parkinson-Erkrankung, d. h. Störungen des Rapid-Eye-Movement (REM)-Schlafes und des Vegetativums, in einem patientennahen Monitoring zu berücksichtigen.Ergebnis ist ein modularer Demonstrator bestehend aus mobilem Messgerät mit gekoppeltem Tablet sowie einer Webapplikation für Patienten (App) mit begleitender Analysesoftware, welche die Analyse von vegetativen Funktionen, Schlaf, Bewegung und kognitiven Funktionen integriert.Das Ergebnis ist die Kombination eines mobilen Messgeräts zum Schlafmonitoring nach den Kriterien der American Academy of Sleep Medicine (AASM) mit Nachtkamera, neurovegetativen Tests sowie eines elektronischen Patienten-Tagebuches für zu Hause. Das Patienten-Tagebuch, die neurovegetative Diagnostik und das Schlafmonitoring könnten unabhängig voneinander zum Einsatz kommen.
Colorectal endoscopic submucosal dissection using the water pressure method for diverticulum-associated lesions: A case series study (with video)
Authors: Masunaga Teppei , Kato Motohiko , Sasaki Motoki , Iwata Kentaro , Miyazaki Kurato , Kubosawa Yoko , Mizutani Mari , Takatori Yusaku , Matsuura Noriko , Nakayama Atsushi , Kaoru Takabayashi , Yahagi Naohisa 
Published: October 2022

Abstract
Background and study aims Colorectal endoscopic submucosal dissection (ESD) of diverticulum-associated lesions is challenging because these lesions require precise excision in narrow spaces. The water pressure method (WPM) uses active water pressure by the waterjet function under saline solution-filled conditions. This study aimed to determine the feasibility of WPM for resection of diverticulum-associated lesions.
Patients and methods This was a retrospective, observational case series study. We reviewed diverticulum-associated lesions treated by ESD with WPM at our institution between June 2017 and July 2021. Diverticulum-associated lesions were classified as follows: type 1, lesions in contact with or within 3 mm of the edge of a diverticulum; type 2, lesions that partially infiltrated the interior of a diverticulum; and type 3, lesions that infiltrated the interior of and completely covered the diverticulum. We collected data on the clinical characteristics and outcomes of the lesions.
Results Seven diverticulum-associated lesions were treated with ESD using WPM. The median lesion size was 37 mm (interquartile range: 25–54 mm). There were three cases of type 1, three cases of type 2, and one case of type 3. Three lesions were resected circumventing the diverticulum, and four lesions involved resection of the diverticulum. The en bloc resection and R0 resection rates were 86 %. One patient had severe fibrosis, which caused perforation, and in another patient, the diverticulum was too deep and narrow to be completely isolated.
Conclusions WPM allowed for precise procedures in the diverticulum. The feasibility of WPM has been suggested for diverticulum-associated lesions, although cases have been complex.
Impacto da suspensão das cirurgias eletivas em pacientes com escoliose idiopática do adolescente no período da pandemia de covid-19
Authors: Castanheira Matheus Neves , Nardone Giovanni Salvatore , Luciano Rafael de Paiva , Leite Márcio Squassoni 
Published: October 2022

Resumo
Objetivos Neste estudo foram avaliadas as progressões radiográficas das curvas escolióticas, acima de 40 graus em pacientes com escoliose idiopática do adolescente (EIA). Os indivíduos analisados aguardavam o procedimento cirúrgico, em período de suspensão das cirurgias eletivas, durante a pandemia de covid-19. Além das progressões radiográficas, nesta pesquisa foi descrita a qualidade de vida destes pacientes.
Métodos O artigo refere-se a um estudo de coorte retrospectivo, que avaliou 29 pacientes com EIA com indicação cirúrgica, todos cadastrados no serviço público de saúde brasileiro. As medidas radiográficas escolióticas dos pacientes foram comparadas em dois momentos: no início do período da interrupção de cirurgias eletivas, devido à pandemia de covid-19, e logo após a liberação destas.
Resultados A partir da comparação das medidas radiográficas entre as avaliações pré e pós suspensão das cirurgias eletivas, observamos o aumento significativo dos valores angulares da curva principal (p < 0,001), com variações entre 0 e 68°, e mediana de 10°. Em relação às curvas secundárias, observamos um aumento dos valores angulares da região torácica proximal (p < 0,001) e lombar (p = 0,001). Entretanto, o aumento da região torácica principal não foi considerado significativo (p = 0,317).
Conclusão A suspensão das cirurgias eletivas, para a correção da EIA resultou em um aumento significativo no valor radiográfico das deformidades das colunas dos pacientes, fator que promoveu um impacto negativo na qualidade de vida de pacientes e familiares.
Nerve Palsy following Total Hip Arthroplasty: A Review of the Current Literature
Authors: Salandra Jonathan , Deliso Marisa , Tang Alex , Robbins Conner J. , Rao Juluru P. 
Published: October 2022

AbstractThe incidence of postoperative nerve palsy following total hip arthroplasty (THA) is reported to be 1 to 2%. The most common injury is to the sciatic nerve, but other nerve palsies including the femoral, obturator, and pudendal nerves, have been implicated. There is also an increased risk of nerve palsy following THA in female patients, those who undergo revision procedures, and those with a previous history of developmental hip dysplasia. The prognosis for recovery for each nerve palsy is directly correlated to the extent of nerve damage. Prevention is always the best form of treatment for these conditions, and one method by which this may be accomplished is through electromyography and other variations of intraoperative observation.
Bilateral Simultaneous Middle Cerebral Artery Mechanical Thrombectomy for Periprocedural Transcatheter Aortic Valve Implantation Stroke: A Case Report
Authors: Govindappa Sharath Kumar Goddu , M. Jayranganath , Jose John , M. Somashekar C , Adiga Chaitra Parameshwara 
Published: October 2022

AbstractMechanical thrombectomy has been described as the prompt procedure for emergent large vessel occlusion strokes resulting from cardioembolic events, arterial lesion-to-artery embolism, or from in situ atherosclerosis. This is the first reported case of an elderly woman who presented with bilateral paresis, progressive drowsiness, and dysarthria due to bilateral middle cerebral arterial occlusion, originating from the aortic valve, after transcatheter aortic valve implantation, leading to stroke. Despite intravenous thrombolysis being begun for this patient, it proved ineffective and she underwent mechanical thrombectomy, which led to complete revascularization of bilateral middle cerebral arteries following which she completely recovered without any deficits.
Below Knee Angioplasty Using Drug-Eluting Balloons in Patients with Critical Limb Ischemia with Six Months Follow-Up: Single-Center Experience at Tertiary Care Hospital
Authors: Rathod Jawahar , Sheorain Virender , Jaybhay Shivprasad , Shaikh Rajjat , Bangde Pratik 
Published: October 2022

Abstract
Purpose The aim of this study was to evaluate 6 monthly safety and primary patency rates of drug-eluting balloons (DEB) angioplasty in below-the-knee (BTK) arteries in critical limb ischemia (CLI) patients.
Methods A prospective observational study was conducted over 2 years in a tertiary care center. A total of 25 patients with CLI were enrolled in this study. Inclusion criteria were patients presenting with CLI (Rutherford class 4 or greater), equal to or more than 50% luminal stenosis or occlusion of at least one tibial artery, and agreement to 6-month evaluation. Exclusion criteria were life expectancy less than 1 year, allergy to paclitaxel, and contraindication to antiplatelet treatment.Follow-up was performed by clinical and Doppler assessment. The primary endpoint was a 6-month primary patency rate, and secondary endpoints were changes in the Rutherford class and incidence of major amputation. Restenosis rate is defined as a reduction in the luminal diameter by 50% or greater by duplex ultrasound.
Results Six-month primary patency was achieved in 19 (76%) patients. Both Rutherford category improvement and reduction in the percentage of stenosis after angioplasty were statistically significant (p-value <0.0001). At 6 months, better patency rates were seen among diabetics (88.8%) than smokers (69.2%). Limb salvage was observed in 24 (96%) patients with one major amputation (above the ankle).
Conclusion DEBs have shown safe and promising clinical outcomes with successful performance in infrapopliteal arteries in the short-term follow-up. DEB had a substantial 6-month primary patency rate. DEB angioplasty is a safe and effective treatment option for CLI patients with BTK vascular disease.
The effect of the price of time on healthcare provider choice in Ghana
Authors: Sarkodie Adu Owusu 
Published: October 2022

AbstractThe existing literature confirms that the cost of treatment affects the choice of a particular healthcare provider. The Ghana National Health Insurance Scheme was established in 2003 to reduce the cost of healthcare provision and increase access to healthcare. However, we find that that even when the price is assumed to be “zero”, there remain some economic costs for choosing a particular healthcare provider over the other. This is called the price of time or opportunity cost. The study uses data from the seventh round of the Ghana Living Standards Survey (GLSS 7) conducted in 2016/2017 and employs multinomial probit regression as the technique for the analysis. The study finds that travel time and waiting time have significant effects on the choice of healthcare provider. If travel time and waiting time increase by 1 h, it will decrease the probability of seeking healthcare by 12% and 17%, respectively. Travel cost was not found to have a significant effect. The recommendations are that policymakers should make the effort to decrease travel time and waiting time at the health facilities in the country to improve healthcare delivery.
Simulation of the spatio-temporal evolution of the electron energy distribution function in a pulsed hollow-cathode discharge
Authors: ASHURBEKOV N A , IMINOV K O , RABADANOV K M , SHAKHSINOV G S , ZAKARYAEVA M Z , KURBANGADZHIEVA M B 
Published: October 2022

Abstract
This article presents the 2D simulation results of a nanosecond pulsed hollow cathode discharge obtained through a combination of fluid and kinetic models. The spatio-temporal evolution of the electron energy distribution function (EEDF) of the plasma column and electrical characteristics of the nanosecond pulsed hollow cathode discharge at a gas pressure of 5 Torr are studied. The results show that the discharge development starts with the formation of an ionization front at the anode surface. The ionization front splits into two parts in the cathode cavity while propagating along its lateral surfaces. The ionization front formation leads to an increase in the fast isotropic EEDF component at its front, as well as in the anisotropic EEDF component. The accelerated electrons enter the cathode cavity, which significantly contributes to the formation of the high-energy EEDF component and EEDF anisotropy.
Prediction tool Development and Implementation in pharmacy praCTice (PreDICT) proposed guidance
Authors: Riester Melissa R , Zullo Andrew R 
Published: October 2022

AbstractPurposeProposed guidance is presented for Prediction tool Development and Implementation in pharmacy praCTice (PreDICT). This guidance aims to assist pharmacists and their collaborators with planning, developing, and implementing custom risk prediction tools for use by pharmacists in their own health systems or practice settings. We aimed to describe general considerations that would be relevant to most prediction tools designed for use in health systems or other pharmacy practice settings.SummaryThe PreDICT proposed guidance is organized into 3 sequential phases: (1) planning, (2) development and validation, and (3) testing and refining prediction tools for real-world use. Each phase is accompanied by a checklist of considerations designed to be used by pharmacists or their trainees (eg, residents) during the planning or conduct of a prediction tool project. Commentary and a worked example are also provided to highlight some of the most relevant and impactful considerations for each phase.ConclusionThe proposed guidance for PreDICT is a pharmacist-focused set of checklists for planning, developing, and implementing prediction tools in pharmacy practice. The list of considerations and accompanying commentary can be used as a reference by pharmacists or their trainees before or during the completion of a prediction tool project.
Forest cover and geographical distance influence fine-scale genetic structure of leaf-toed geckos in the tropical dry forests of western Mexico
Authors: French Connor M , Berezin Casey-Tyler , Overcast Isaac , Méndez De La Cruz Fausto R , Basu Saptarsi , Martínez Bernal Roberto Lhemish , Murphy Robert W , Hickerson Michael J , Blair Christopher 
Published: October 2022

Abstract
The biodiversity within tropical dry forests (TDFs) is astounding and yet poorly catalogued due to inadequate sampling and the presence of cryptic species. In the Mexican TDF, endemic species are common, and the landscape has been continually altered by geological and anthropogenic changes. To understand how landscape and environmental variables have shaped the population structure of endemic species, we studied the recently described species of leaf-toed gecko, Phyllodactylus benedettii, in coastal western Mexico. Using double-digest restriction site-associated DNA sequencing data, we first explore population structure and estimate the number of ancestral populations. The results indicate a high degree of genetic structure with little admixture, and patterns corresponding to both latitudinal and altitudinal gradients. We find that genetic structure cannot be explained purely by geographical distance, and that ecological corridors may facilitate dispersal and gene flow. We then model the spatial distribution of P. benedettii in the TDF through time and find that the coastline has been climatically suitable for the species since the Last Glacial Maximum. Landscape genetic analyses suggest that the combination of isolation by distance (IBD) and isolation by resistance (IBR; forest cover) has influenced the spatial genetic structure of the species. Overall, our genomic data demonstrate fine-scale population structure in TDF habitat, a complex colonization history, and spatial patterns consistent with both IBD and other ecological factors. These results further highlight the Mexican TDF as a diversity hotspot and suggest that continued anthropogenic changes are likely to affect native fauna.
The effect of vitamin B supplementation on neuronal injury in people living with HIV: a randomized controlled trial
Authors: Tyrberg Erika , Hagberg Lars , Andersson Lars-Magnus , Nilsson Staffan , Yilmaz Aylin , Mellgren Åsa , Blennow Kaj , Zetterberg Henrik , Gisslén Magnus 
Published: October 2022

Abstract
Effective antiretroviral therapy has radically changed the course of the HIV pandemic. However, despite efficient therapy, milder forms of neurocognitive symptoms are still present in people living with HIV. Plasma homocysteine is a marker of vitamin B deficiency and has been associated with cognitive impairment. People living with HIV have higher homocysteine concentrations than HIV-negative controls, and we have previously found an association between plasma homocysteine concentration and CSF concentration of neurofilament light protein, a sensitive marker for ongoing neuronal injury in HIV. This prompted us to perform this randomized controlled trial, to evaluate the effect of vitamin B supplementation on neuronal injury in a cohort of people living with HIV on stable antiretroviral therapy. At the Department of Infectious Diseases at Sahlgrenska University Hospital in Gothenburg, Sweden, 124 virally suppressed people living with HIV were screened to determine eligibility for this study. Sixty-one fulfilled the inclusion criteria by having plasma homocysteine levels at or above 12 μmol/l. They were randomized (1:1) to either active treatment (with cyanocobalamin 0.5 mg, folic acid 0.8 mg and pyridoxine 3.0 mg) q.d. or to a control arm with a cross over to active treatment after 12 months. Cognitive function was measured repeatedly during the trial, which ran for 24 months. We found a significant correlation between plasma neurofilament light protein and plasma homocysteine at screening (n = 124, r = 0.35, P &lt; 0.0001). Plasma homocysteine levels decreased by 35% from a geometric mean of 15.7 μmol/l (95% confidence interval 14.7–16.7) to 10.3 μmol/l (95% confidence interval 9.3–11.3) in the active treatment arm between baseline and Month 12. No significant change was detected in the control arm during the same time period [geometric mean 15.2 (95% confidence interval 14.3–16.2) versus geometric mean 16.5 μmol/l (95% confidence interval 14.7–18.6)]. A significant difference in change in plasma homocysteine levels was seen between arms at 12 months [−40% (95% confidence interval −48 to −30%), P &lt; 0.001]. However, no difference between arms was seen in either plasma neurofilament light protein levels [−6.5% (−20 to 9%), P = 0.39], or cognitive measures [−0.08 (−0.33 to 0.17), P = 0.53]. Our results do not support a vitamin B–dependent cause of the correlation between neurofilament light protein and homocysteine. Additional studies are needed to further elucidate this matter.