bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventions to enhance eudaemonic psychological well‐being: A meta‐analytic review with Ryff's Scales of Psychological Well‐being
Authors: van Dierendonck Dirk , Lam Hodar 
Published: September 2022

AbstractThis meta‐analysis enhances our insight into the effectiveness of interventions aimed at improving eudaemonic well‐being. The focal outcome of these interventions is Ryff's Scales of Psychological Well‐being. We summarized experimental studies and concluded whether a specific intervention approach improves individual positive functioning by assessing the six dimensions of psychological well‐being and the composite score of well‐being. Our study confirmed that eudaemonic well‐being can be improved. The strongest influence is seen in integral programs that link directly to Ryff's conceptual model. Breaking down to dimensional scores, existing interventions had the strongest influence on Environmental Mastery, Personal Growth, and Self‐Acceptance. The weakest influence was on Autonomy and Positive Relations with Others. Overall, our result is an important contribution to the well‐being literature in that it shows, more convincing than previous meta‐analyses due to its exclusive and comprehensive focus on Ryff's model, that psychological eudaemonic well‐being can be enhanced by targeted intervention programs.
Association of maternal psychological distress with children with overweight/obesity in Ethiopia
Authors: Biadgilign Sibhatu , Mgutshini Tennyson , Deribew Amare , Gelaye Bizu , Memiah Peter 
Published: September 2022

AbstractBackgroundPoor maternal mental health is a major risk factor for adverse offspring health outcomes, including overweight/obesity status. Maternal mental distress is highly prevalent and associated with parenting practices influencing child weight. To date, there is little information documented in Ethiopia on maternal mental distress and children with overweight/obesity status. This study examined the association between maternal mental distress and children with overweight/obesity among mother–child dyads in Addis Ababa, Ethiopia.MethodsAn observational population‐based cross‐sectional study was conducted among mother–child dyads in representative samples in Addis Ababa, Ethiopia. Maternal mental distress was measured using the Self‐Reporting Questionnaire (SRQ)‐20. Child/adolescent overweight/obesity was defined as more than 1 SD above the median World Health Organization (WHO) growth reference. Multivariate logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).ResultsThe prevalence of maternal mental distress and children with overweight/obesity was estimated to be 10.1% and 28.8%, respectively. After adjusting for confounders, including maternal education, maternal occupation, average monthly household income, maternal body mass index (BMI) and the number of household members/family size, maternal psychological distress was not associated with offspring overweight/obesity status (adjusted OR [aOR] = 0.54; 95% CI: 0.25, 1.14).ConclusionsThere is no evidence of an association between maternal psychological distress and children with overweight/obesity. This lack of association might be attributable to our cross‐sectional study design. Future epidemiologic studies, particularly those using prospectively collected data, are warranted to examine better the effects of maternal psychological distress on offspring body weight.
The role of epigenetics in multi‐generational transmission of asthma: An NIAID workshop report‐based narrative review
Authors: Wheatley Lisa M. , Holloway John W. , Svanes Cecilie , Sears Malcolm R. , Breton Carrie , Fedulov Alexey V. , Nilsson Eric , Vercelli Donata , Zhang Hongmei , Togias Alkis , Arshad Syed Hasan 
Published: September 2022

AbstractThere is mounting evidence that environmental exposures can result in effects on health that can be transmitted across generations, without the need for a direct exposure to the original factor, for example, the effect of grandparental smoking on grandchildren. Hence, an individual's health should be investigated with the knowledge of cross‐generational influences. Epigenetic factors are molecular factors or processes that regulate genome activity and may impact cross‐generational effects. Epigenetic transgenerational inheritance has been demonstrated in plants and animals, but the presence and extent of this process in humans are currently being investigated. Experimental data in animals support transmission of asthma risk across generations from a single exposure to the deleterious factor and suggest that the nature of this transmission is in part due to changes in DNA methylation, the most studied epigenetic process. The association of father's prepuberty exposure with offspring risk of asthma and lung function deficit may also be mediated by epigenetic processes. Multi‐generational birth cohorts are ideal to investigate the presence and impact of transfer of disease susceptibility across generations and underlying mechanisms. However, multi‐generational studies require recruitment and assessment of participants over several decades. Investigation of adult multi‐generation cohorts is less resource intensive but run the risk of recall bias. Statistical analysis is challenging given varying degrees of longitudinal and hierarchical data but path analyses, structural equation modelling and multilevel modelling can be employed, and directed networks addressing longitudinal effects deserve exploration as an effort to study causal pathways.
Sam50 exerts neuroprotection by maintaining the mitochondrial structure during experimental cerebral ischemia/reperfusion injury in rats
Authors: Yin Xulong , Wang Jiahe , Yang Siyuan , Li Haiying , Shen Haitao , Wang Hui , Li Xiang , Chen Gang 
Published: September 2022

AbstractAimTo investigate the role of Sam50, a barrel protein on the surface of the mitochondrial outer membrane, in cerebral ischemia–reperfusion (I/R) injury and its underlying mechanisms.MethodsA middle cerebral artery occlusion/reperfusion (MCAO/R) model in adult male Sprague–Dawley rats was established in vivo, and cultured neurons were exposed to oxygen–glucose deprivation/reoxygenation (OGD/R) to simulate I/R injury in vitro. Lentiviral vector encoding Sam50 or Sam50 shRNA was constructed and administered to rats by intracerebroventricular injection to overexpress and knockdown Sam50, respectively.ResultsFirst, after MCAO/R induction, the mitochondrial structure was damaged, and Sam50 protein levels were increased responsively both in vivo and in vitro. Then, it was found that Sam50 overexpression could reduce infarction size, inhibit neuronal cell death, improve neurobehavioral disability, protect mitochondrial structure integrity, and ameliorate mitochondrial dysfunction, which was induced by I/R injury both in vivo and in vitro. However, Sam50 downregulation showed the opposite results and aggravated I/R injury by inducing neuronal cell death, neurobehavioral disability, and mitochondrial dysfunction. Moreover, we found that the interaction between Sam50 and Mic19 was broken off after OGD/R, showing that the Sam50–Mic19–Mic60 axis was breakage in neurons, which would be a reason for mitochondrial structure and function abnormalities induced by I/R injury.ConclusionSam50 played a vital role in the protection of neurons and mitochondria in cerebral I/R injury, which could be a novel target for mitochondrial protection and ameliorating I/R injury.
Superficial low‐grade fibromyxoid sarcoma
Authors: Ronen Shira , Ko Jennifer S. , Rubin Brian P. , Kilpatrick Scott E. , Wang Wei‐Lien , Lazar Alexander J. , Goldblum John R. , Billings Steven D. 
Published: September 2022

AbstractBackgroundLow‐grade fibromyxoid sarcoma (LGFMS) typically involves deep soft tissue (beneath the fascia) of the proximal extremities and trunk. Long‐term follow‐up has shown a high rate of local recurrence, metastasis, and death. To the best of our knowledge, there is only one previous large series focusing on superficial LGFMS suggesting superficial tumors are disproportionately more common in children and may have a better prognosis. Our study's primary goals are to confirm these findings and increase general awareness that LGFMS may arise in superficial soft tissue.MethodsWe retrieved our cases of superficial LGFMS diagnosed between 2008 and 2020. Available slides were reviewed, and clinical data and follow‐up information were obtained.ResultsThe patients included nine males and 14 females with a median age of 29 years; eight (35%) were children (<18 years) and five (22%) were young adults (18–30 years). The majority involved the lower extremities (65%). The tumors were primarily centered in the subcutis (91%) and dermis (9%). Microscopically, they had typical features of LGFMS with alternating fibrous and myxoid zones composed of bland, slightly hyperchromatic spindled cells. All were positive for MUC4 by immunohistochemistry and/or FUS rearrangement by FISH. Follow‐up on 14 cases ranged from 11 to 148 months (median 61 months) with no evidence of recurrences or distant metastases.ConclusionsCompared to conventional deep‐seated counterparts, superficial LGFMS is more likely to occur in the extremities of children and young adults and may have a better clinical outcome. Further studies with longer follow‐up will likely help support these findings.
Differentiating typical Tako‐tsubo syndrome from extensive anterior STEMI: Look behind the anterior wall
Authors: Berti Marco , Pernigo Matteo , Dinatolo Elisabetta , Cozza Fabiana , Cuccia Claudio 
Published: September 2022

AbstractBackgroundTako‐tsubo syndrome (TTS) in its most typical form shares common features with anterior ST‐segment elevation myocardial infarction (AMI) during acute presentation. Differential diagnosis between the two conditions is often challenging especially if ST‐segment elevation is associated with extensive apical akinesis.MethodsWe sought to systematically analyze ECG and echocardiographic parameters including LV longitudinal strain and two new indexes: the inferior‐apex ratio (IAR) and the inferior‐lateral‐apex ratio (ILAR), to assess if ventricular involvement may be different in TTS and AMI.ResultsA retrospective cohort study was conducted with two groups: patients with TTS (n = 22) and patients with extensive anterior STEMI (n = 22). Lack of ST elevation in V1 was associated with TTS with sensitivity and specificity of 86%, positive and negative predictive value of 86%. Longitudinal strain in mid inferior and mid inferior‐lateral segments were more compromised in TTS: −4.3 ± 6.4% and −5.4 ± 5.4% in TTS versus −10.2 ± 5.5% and −9.9 ± 4.9% in AMI, respectively (p < .01 for all). By multivariate analysis, both longitudinal strain values, inferior‐apical ratio (IAR) < 1 and inferior‐lateral‐apical ratio (ILAR) < 1 were independently associated with diagnosis of TTS during acute phase.ConclusionsOur results suggest that impaired contractility extending beyond apex to mid inferior and inferior‐lateral walls can be easily assessed by IAR and ILAR, and these indexes facilitate non‐invasive differentiation of TTS from extensive anterior STEMI.
Dataset for reporting of gastrointestinal stromal tumours: recommendations from the International Collaboration on Cancer Reporting (ICCR)
Authors: Hornick Jason L , Webster Fleur , Dei Tos Angelo Paolo , Hemmings Chris , Miettinen Markku , Oda Yoshinao , Raut Chandrajit P , Rubin Brian P , Von Mehren Margaret , Wardelmann Eva , Fletcher Christopher D M 
Published: September 2022

Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract and are among the most frequent sarcomas. Accurate diagnosis, classification, and reporting are critical for prognostication and patient management, including selection of appropriate targeted therapy. Here we report on international consensus‐based datasets for the pathology reporting of biopsy and resection specimens of GIST. The datasets were produced under the auspices of the International Collaboration on Cancer Reporting (ICCR), a global alliance of major international pathology and cancer organizations. An international expert panel consisting of pathologists, a surgical oncologist, and a medical oncologist produced a set of core and noncore data items for biopsy and resection specimens based on a critical review and discussion of current evidence. All professionals involved were subspecialized soft tissue tumour experts and affiliated with tertiary referral centres. Commentary was provided for each data item to explain its clinical relevance and the rationale for selection as a core or noncore element. Following international public consultation, the datasets, which include synoptic reporting guides, were finalized and ratified, and published on the ICCR website. These first international datasets for GIST are intended to promote high‐quality, standardised pathology reporting. Their widespread adoption will improve consistency of reporting, facilitate multidisciplinary communication, and enhance comparability of data, all of which will ultimately help to improve the management of patients with GIST. All the ICCR datasets, including these on GIST, are freely available worldwide on the ICCR website (www.iccr‐cancer.org/datasets).
Challenges around quantifying uncertainty in a holistic approach to hard‐to‐heal wound management: Health economic perspective
Authors: Veličković Vladica , Janković Dina 
Published: September 2022

AbstractTreatment of hard‐to‐heal wounds involves a holistic approach for choosing between available treatment options. However, evidence for informing these choices is sparse, introducing uncertainty into decisions about the optimum treatment pathways that reflect the vast heterogeneity in this patient population. This paper discusses the existing clinical and health economic literature in order to provide insight into sources of uncertainty in the evaluation of the holistic approach to management of the hard‐to‐heal wounds, and how this uncertainty can be appropriately reflected in research. We identified three key sources of uncertainty in the evaluation of chronic wound treatments, namely heterogeneity in aetiology and patient populations, heterogeneity in treatment pathways, and challenges around capturing all relevant outcomes. Reflecting these complexities requires sophisticated modelling of treatment sequencing and long‐term outcomes. The paper discusses how the scope specification, scenario analyses, and sensitivity analyses can be used to fully characterise analytical uncertainty.
Pericarditis following left atrial ablation
Authors: Aksu Tolga , Mutluer Ferit O. , Tanboga Halil I. , Gupta Dhiraj 
Published: September 2022

AbstractIntroductionWe aimed to evaluate the incidence of acute pericarditis following cardioneuroablation (CNA) and to compare this with patients undergoing left atrial (LA) radiofrequency ablation for atrial fibrillation (AF).Methods and ResultsThis is a single‐center prospective study. During the study period, CNA for vasovagal syncope was performed in 42 patients, pulmonary vein isolation (PVI) for paroxysmal AF in 46 patients, and posterior wall isolation (PWI) in addition to PVI for persistent AF in 22 patients. Pericarditis was reported by 18 (16.4%) patients overall: 1 (2.4%) patient in CNA group, 8 (17.4%) patients in PVI group, and 9 (40.9%) patients in PWI (p < .001). On univariable logistic regression analysis, CNA was associated with a lower risk of pericarditis (odds ratio 0.11, 95% confidence interval [CI] 0.01–0.97), while ablation of PWI plus PVI was associated with a higher risk of pericarditis compared with PVI (odds ratio 3.29, 95% CI 1.05–10.3).ConclusionThis study shows that pericarditis is extremely uncommon following CNA and is significantly less frequent than following AF ablation. This difference is likely related to the much lower amount of LA ablation necessary in this group.
The effect of breastfeeding support provided by video call on postpartum anxiety, breastfeeding self‐efficacy, and newborn outcomes: A randomized controlled study
Authors: Akyıldız Deniz , Bay Betül 
Published: September 2022

AbstractAimTo examine the effects of breastfeeding support given by video call on anxiety, breastfeeding self‐efficacy, and newborn outcomes.MethodsWe conducted a randomized controlled experimental trial with 72 women and their babies. Participants were randomly assigned to the intervention (video call) group (VCG: standard care + video call) and control group (CG: standard care). The primary outcomes of this study were the mean postpartum maternal anxiety level and the mean breastfeeding self‐efficacy level. The secondary outcome was neonatal outcomes. This study followed the CONSORT (Consolidated Standards of Reporting Trials) checklist.ResultsWomen in VCG had lower anxiety levels than the CG at postpartum 2 weeks (mean difference [MD] 25.42, p = .000) and 1 month (MD 47.72, p = .000). The breastfeeding self‐efficacy level of women in the VCG was higher than the CG at postpartum 2 weeks (MD 13.18, p = .007) and 1 month (MD 10.1, p = .001). The newborns in VCG had higher weight gain and daily breastfeeding frequency than the CG at the postpartum second week (MD 9.64, p = .001, MD 2.88, p = .000; respectively) and 1 month (MD 47.16, p = .000, MD 2.98, p = .000; respectively). There were lower rates of challenges of breastfeeding, hyperbilirubinemia, and feeding with formula in VCG than CG at the postpartum second week (p = .043, p = .043, p = .039; respectively).ConclusionsBreastfeeding support via video calling has positive effects on maternal anxiety, breastfeeding self‐efficacy, and newborn health. Postpartum caregivers may benefit from video calling for breastfeeding support.
Sini powder with paroxetine ameliorates major depressive disorder by modulating circadian rhythm: A randomized, double‐blind, placebo‐controlled trial
Authors: He Xu , Zhang Ruihuan , Li Zhe , Yao Zhen , Xie Xiaoxia , Bai Ruoxue , Li Lan , Zhang Xu , Zhang Sha , Shen Yan , Li Shaowei , Hui Zhenliang , Liu Rongrong , Chen Jun 
Published: September 2022

AbstractCircadian rhythm disorder is a significant risk factor for mental diseases, and the recovery of circadian rhythm function has gradually become a signal of effective antidepressant therapy. Sini powder (SNP) is a classical, traditional Chinese formula for depression treatment. However, few clinical reports have been recorded. This randomized, double‐blinded, controlled trial (ChiCTR1900022700) aimed to explore the efficacy of SNP on depression via regulating circadian rhythm. In total, 36 patients with major depressive disorder (MDD) were enrolled for 4‐weeks medication and 6‐weeks follow‐up. HAMD‐24 score and circadian rhythm index, including dim light melatonin onset (DLMO) and phase angle difference (PAD), were included in the assessment. DLMO and PAD were statistically significant in the SNP group after 4 weeks of treatment (p < .05) and with greater improvement in DLMO (p = .03). In addition, DLMO and the HAMD‐24 score showed a positive correlation (p < .05); the HAMD‐24 score degree decreased significantly over time (p < .001). Similarly, interaction effects were shown significantly between group and time (p = .049). The duration of SNP supplementation was relatively short, and the sample size was relatively small. SNP granules combined with paroxetine tablets have definite efficacy in improving the circadian rhythms of MDD patients, reflecting the therapeutic advantages of traditional Chinese medicine as antidepressants.
Chromosome‐level genome assembly and functional characterization of terpene synthases provide insights into the volatile terpenoid biosynthesis of Wurfbainia villosa
Authors: Yang Peng , Zhao Hai‐Ying , Wei Jie‐Shu , Zhao Yuan‐Yuan , Lin Xiao‐Jing , Su Jing , Li Fang‐Ping , Li Meng , Ma Dong‐Ming , Tan Xu‐Kai , Liang Hui‐Lin , Sun Ye‐Wen , Zhan Ruo‐Ting , He Guo‐Zhen , Zhou Xiao‐Fan , Yang Jin‐Fen 
Published: September 2022

SUMMARYWurfbainia villosa is a well‐known medicinal and edible plant that is widely cultivated in the Lingnan region of China. Its dried fruits (called Fructus Amomi) are broadly used in traditional Chinese medicine for curing gastrointestinal diseases and are rich in volatile terpenoids. Here, we report a high‐quality chromosome‐level genome assembly of W. villosa with a total size of approximately 2.80 Gb, 42 588 protein‐coding genes, and a very high percentage of repetitive sequences (87.23%). Genome analysis showed that W. villosa likely experienced a recent whole‐genome duplication event prior to the W. villosa–Zingiber officinale divergence (approximately 11 million years ago), and a recent burst of long terminal repeat insertions afterward. The W. villosa genome enabled the identification of 17 genes involved in the terpenoid skeleton biosynthesis pathway and 66 terpene synthase (TPS) genes. We found that tandem duplication events have an important contribution to the expansion of WvTPSs, which likely drove the production of volatile terpenoids. In addition, functional characterization of 18 WvTPSs, focusing on the TPS‐a and TPS‐b subfamilies, showed that most of these WvTPSs are multi‐product TPS and are predominantly expressed in seeds. The present study provides insights into the genome evolution and the molecular basis of the volatile terpenoids diversity in W. villosa. The genome sequence also represents valuable resources for the functional gene research and molecular breeding of W. villosa.
La intermediación en los sistemas de innovación agroindustrial
Authors: Guarin Manrique Leidy Dayhana , Martínez Ardila Hugo Ernesto 
Published: September 2022

Atendiendo a la importancia que los sistemas de innovación agroindustrial están tomando en los países en vía de desarrollo, tal como Colombia (territorio de vocación agrícola por naturaleza), se presenta un acercamiento a su concepto y a la importancia que representa la intermediación en la transferencia de conocimiento y tecnología entre los diversos actores de la cuádruple hélice que conforman a este tipo de sistema sectorial. Es así que se ha realizado una búsqueda de literatura en Google Scholar, Scopus y Web of Science, así como resultados de otras investigaciones enfocadas a estudiar el rol de los agentes intermediarios en los procesos de innovación relacionados con el agro.
Numerical Evaluation of an Efficient Deep-Water Mooring Configuration Designed to Allow a Fast Identification of Failure Events
Authors: Kochem Rodrigo Moretti , Correa Fabrício Nogueira , Jacob Breno Pinheiro 
Published: September 2022

Abstract
This work proposes a taut-leg deep-water mooring configuration with buoys, designed specifically to allow a quick and easy visual identification of the rupture of any mooring line of the system. This addresses one of the main concerns of the offshore oil and gas industry: the significant number of events of mooring line failure that has been recently observed in actual operations in deep and ultra-deep water scenarios; field experience indicates that, in current spread-mooring systems, several weeks may pass until a failure is detected. The proposed configuration also presents the additional advantages of reducing the mooring radius and the tensions on the top of the lines. The configuration is evaluated and compared with a standard taut-leg system, considering the same base case study of a typical deep-water FPSO, and using up-to-date numerical methods implemented into an in-house fully coupled nonlinear time-domain dynamic analysis tool. The results indicated that the proposed configuration provided significant improvements in the cost and performance of the mooring system, in terms of line lengths, mooring radii, tensions, and offsets; and confirmed that the buoy emerges and reaches the surface in the event of a line rupture, irrespective of the point where the line has broken. This indicates that the resulting configuration is a promising technical alternative to traditional standard taut-leg systems in deep and ultra-deep water scenarios.