bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of the composition of emulsifiers and the dispersion medium on the properties of bases for semi-solid preparations
Authors: Lyapunov Nikolay , Bezuglaya Elena , Liapunova Anna , Zinchenko Igor , Liapunov Oleksii , Lysokobylka Oleksii , Stolper Yurij 
Published: November 2022

The aim. To study the effect of cetostearyl alcohol (CSA) on the rheological properties of bases with different dispersion media, the release of propylene glycol (PG) from them, and the ability of these bases to absorb water.
Materials and methods. Micelles of a non-ionic surfactant and its aggregates with CSA in a mixed solvent where the structure of water prevails, mixed solvent PG – macrogol 400 (M400) and hydrophilic bases-vehicles with different dispersion media were studied. The research was carried out by the spin probe method using a probe simulating a cationic surfactant and by rotational viscometry. The microstructure of the bases was studied by optical microscopy. The in vitro release test to study the release of PG and M400 from solutions and bases was performed using vertical diffusion chambers. The content of PG and M400 in the dialysate was determined by gas chromatography according to the validated analytical procedures. The absorption of water by solutions and bases was determined by dialysis through the membrane.
Results. CSA, which was the part of the bases together with surfactants in certain ratios, was a significant factor in increasing their rheological parameters, reducing the parameters of PG release during in vitro release tests, as well as reducing water absorption. The mechanisms of such influence are different for bases with different structures of the dispersion medium. In the bases, where the structure of water prevailed, lateral phase separation occurred in the supramolecular structures of surfactant and CSA with the formation of liquid domains of surfactant and solid domains of CSA, which contributed to the formation of coagulation structures. In the mixed non-aqueous solvent PG – M400, surfactant micelles and mixed aggregates of surfactant and CSA molecules were not formed; at 25 oC, surfactants and CSA became separate dispersed phases of suspensions, which contributed to the formation of gels. When CSA was added into an aqueous solution of poloxamer 338, PG, M400 and cationic surfactant, the flow behaviour changed, and the rheological parameters increased, which led to a decrease in the release rate and extended for PG and M400 as well as in the ability to absorb water. The rate and extent of PG release from the solution were greater compared to the M400 release.
Conclusions. The addition of CSA in combination with surfactants into the bases for semi-solid preparations is a significant factor for modifying their rheological parameters, the kinetics of PG release from them, and water absorption during experiments in vitro. The mechanisms of such an effect are different and depend on the composition and structure of the dispersion medium of the base
Las leguminosas del Área Natural Protegida del Boquerón de Tonalá, Oaxaca, México
Authors: Sotuyo Solange , Julio-Catarino Leticia , Contreras-Jiménez José Luis 
Published: November 2022

Antecedentes: El Área de Protección de Flora y Fauna (APFF) Boquerón de Tonalá, posee características climáticas, geológicas y edáficas distintivas, albergando diversos tipos de vegetación. Las leguminosas de la región no han sido inventariadas a detalle en su conjunto.
Preguntas: ¿Cuáles son las especies de leguminosas en el área Natural Protegida del Boquerón de Tonalá, Oaxaca? ¿Existen diferencias en la riqueza de especies por tipo de vegetación?
Sitio y años de estudio: Área de Protección de Flora y Fauna (APFF) Boquerón de Tonalá, Oaxaca; junio de 2017 a junio de 2018.
Métodos: Se eligieron ocho localidades y 14 sitios correspondientes a las comunidades vegetales dominantes que cubren toda el APFF Boquerón de Tonalá y el gradiente altitudinal. Se cubrieron 58 días de trabajo de campo. Los ejemplares colectados por subfamilia, género y especie fueron contabilizados.
Resultados: Se recolectaron 177 ejemplares más sus duplicados, estos corresponden a 85 especies, de 38 géneros de la familia Leguminosae, incluidos en tres subfamilias y del clado Mimosoide que tratamos como separado. El mayor número de géneros y especies encontrados pertenecen a la subfamilia Papilionoideae. Los géneros con mayor número de especies fueron Brongniartia, Mimosa, Senna y Vachellia (antes parte de Acacia). La selva baja caducifolia fue el tipo de vegetación con mayor número de especies y géneros encontrados. Se encontró una especie nueva de Coulteria (subfamilia Caesalpinioideae) en encinares.
Conclusiones: La diversidad florística de leguminosas del APFF Boquerón de Tonalá, muestra que deben reforzarse las estrategias de manejo y conservación en el área.
Ensayo sobre el paisaje urbano y patrimonio arquitectónico de Barra do Bugres, MT. Actividades didácticas en un ambiente digital
Authors: Maciel Sérgio Dias , Carignani Gisele , Tardivo Veruska Pobikrowska 
Published: November 2022

El objetivo de ese artículo es presentar el municipio de Barra do Bugres, en Suroeste mato-grossense, su historia y su paisaje urbano. El municipio tuvo su mayor desarrollo en la década de 1980, con instalación de usina de azúcar y alcohol e inversiones en la infraestructura carreteras pavimentadas. Barra do Bugres posee un campus de la Universidad del Estado de Mato Grosso – UNEMAT y los análisis sobre el espacio urbano y el paisaje urbano son decurrentes de las actividades académicas efectuadas sobre el municipio. Los análisis presentados han traído como fundamentación autores como Cullen (1971), Lynch (2006), Panerai (2007), Lamas (2017) y Costa y Netto (2017), y están divididas entre historia y patrimonio y las ópticas de los autores sobre el paisaje urbano. Los métodos utilizados en esta investigación son las lecturas de datos de documentos públicos, captación de datos adquiridos a través de actividades de campo y procesamiento de diferentes formas de representación, como geoprocesamiento de imágenes de satélite y fotogrametría. El resultado presentado describe como Barra do Bugres expandió a partir de su primer núcleo y consolidó su espacio urbano.
Diabetes, hypertension, smoking, and hyperlipidemia as risk factors for spontaneous cervical artery dissection: Meta-analysis of case-control studies
Authors: Abdelnour Loay Hassan , Eltahir Abdalla Mohammed , Elhassan Samah , Hassan Kheirelseid Elrasheid Ahmed 
Published: November 2022

Background: Spontaneous cervical artery dissection (sCeAD) is an important cause of ischemic stroke in the young population and has a different cardiovascular risk profile from other causes of ischemic stroke. No study provided a comprehensive evidence for cardiovascular risk factors of sCeAD.
Methods: We searched PubMed, MEDLINE, and Embase without date or language restrictions for relevant studies. Bibliographies of included studies were also searched. We included case-control studies where patients with sCeAD were on one arm, and controls were on the other arm. The investigated risk factors were diabetes, hypertension, smoking, and hyperlipidemia. Data extraction and quality assessment were performed independently by two reviewers.
Results: Seventeen qualifying case-control studies were identified, comparing 2185 patients with sCeAD and 3185 healthy control subjects. Heterogeneity was low for diabetes, moderate for hypertension and hyperlipidemia, and high for smoking. The meta-analysis showed a significant association between hypertension and sCeAD [pooled odds ratio (OR) = 1.70, 95% confidence interval (CI): 1.40-2.07, P < 0.001]. There was no association between sCeAD and diabetes (pooled OR = 0.71, 95% CI: 0.50-1.01, P = 0.060) or smoking (pooled OR = 0.90, 95% CI: 0.68-1.20, P = 0.480). Hyperlipidemia was negatively-associated with sCeAD (OR = 0.65, 95% CI: 0.48-0.89, P = 0.007), but with sensitivity analysis, there was no association (OR = 0.72, 95% CI: 0.44-1.19, P = 0.200).
Conclusion: The meta-analysis reveals that sCeAD has a significant association with hypertension and no association with smoking, diabetes, or hyperlipidemia. These results should direct future research towards exploring biological mechanism of hypertension-induced arterial dissection.
Abdominal Wall Synovial Sarcoma, a Rare Presentation
Authors: Nazar Elham , Shabanzade Zohre , Ahmadi Amir 
Published: November 2022

Synovial sarcoma is a malignant mesenchymal neoplasm which com- monly arises in the extremities of adults, in close associationwith joint capsules. Only a few cases of synovial sarcoma occurring in the abdominal wall have been reported. We report an extremely rare case of monophasic synovial sarcoma of abdominal wall in a 58-year-old woman who had presented with painless left ante- rior abdominal wall mass. The patient underwent excisional surgery. Histological and immunohistochemistry examinations revealed monophasic synovial sarcoma. Base on the diagnosis, the patientreceived chemoradiation.Primary synovial sarcoma is rarely found in the anterior abdominal wall. But, it should be included in the differential diagnosis.
Pancreatic Tuberculosis Mimicking a Mass: A Case Report
Authors: Deme Swaroopa , Kakarla Bhaskar , Thakur Rajani , Ramireddygari Purushotham , Rao Modugu Nageswara 
Published: November 2022

Tuberculosis, a preventable and curable disease caused by Mycobacterium tuberculosis, is the leading infectious cause of mortality worldwide. Organs commonly affected are lungs and extrapulmonary organs like lymph nodes, meninges, bones, genitourinary and gastrointestinal tract. Ileocaecal tuberculosis is the commonest form of the gastrointestinal tract. Disseminated infection can involve almost all organs in the body but isolated pancreatic tuberculosis is rarely reported in the literature. Hereby,we report a case of a young female presenting with abdominal pain and further evaluation with imaging revealed pancreatic mass raising suspicion of malignancy. Endoscopic ultrasound (EUS) guided FNAC of pancreatic mass surprisingly revealed necrotizing granulomatous lesions favoring tuberculosis. This was further supported by the complete resolution of the mass with Antituberculous Therapy (ATT). What is important: All pancreatic masses are not malignant. Infectious causes like tuberculosis should be considered in the differential diagnosis which is curable by medication. With a high index of suspicion and adequate workup, unnecessary invasive procedures can be avoided.
Detection of Biofilm Formation by Escherichia coli and Staphylococcus aureus Associated with Canine Pyometra
Authors: Amrutha M.S. , Sankar Surya , Mani Binu K. , Harshan Hiron M. , Vidya P. , Paulson Susmi T. 
Published: November 2022

Background: Antibiotic resistance is one of the major problems encountered in the therapy of canine pyometra. The ability of bacteria to form biofilm is implicated as one of the factors responsible for this. Escherichia coli and Staphylococcus aureus are the predominant bacteria associated with pyometra in canines and are known for their biofilm formation. Keeping in this view, a preliminary study was conducted to detect the biofilm forming strains of E. coli and S. aureus, if any, associated with canine pyometra. Methods: A total of 25 samples were collected, which included uterine discharges from cases of closed pyometra and anterior vaginal swabs from open pyometra. The isolates of E. coli and S. aureus were identified based on the cultural, morphological and biochemical characteristics. These isolates were subjected to antibiotic sensitivity test employing disc diffusion method. For biofilm detection, the isolates were screened by Congo red agar method, tube method and tissue culture plate method. Result: From 25 samples, two Streptococcus spp., thirteen Staphylococcus spp., seven E.coli, five Klebsiella spp. and two Pseudomonas spp. were isolated. All the isolates were found to be multi-drug resistant on antibiogram. The tissue culture plate and Congo red agar method was found more sensitive to detect the biofilm formation by S. aureus and E.coli isolates, respectively. The biofilm forming strains showed higher degree of antibiotic resistance in comparison with non-formers, indicating it as one of the major reasons for failure of antibiotic therapy in canine pyometra.
Experimental Study on Failure Model of Tailing Dam Overtopping under Heavy Rainfall
Authors: Wang Guangjin , Zhao Bing , Lan Rong , Liu Dianwen , Wu Bisheng , Li Yaoji , Li Quanming , Zhou Hanmin , Liu Mingsheng , Liu Wenlian , Liu Xinjie 
Published: November 2022

Abstract
Unusual rainfall is the primary cause of the failure of the tailing dams, and overtopping is the most representative model of the tailing dam failure. The upstream tailing dam was selected as the research object to study the whole process of breach extension and the overtopping dam-failure mechanism under the full-scale rainfall condition. The results showed that the significant size grading phenomenon in the front, middle, and end of the tailing pond was obvious due to the flow separation effect, and its average particle diameter was D50. At different moments of rainfall, the height of the infiltration line at different positions of the dam body was different; at the rainfall of 3600 s, the height of the infiltration line lagged behind the height of the tailing pond, and this phenomenon from the tail of pond to the outside of the dam slope became more obvious. After the rainfall of 3600 s, the height of the infiltration line lagging behind the water level in the pond basically disappeared, and the rate of infiltration line rise kept pace with the rate of water level. The process of overtopping dam-failure experienced dam overtopping (gully erosion), formation of a multistepped small “scarp,” breach rapid expansion, formation of large “scarp,” and burst (fan-shaped formation). The width and depth of the breach showed a positive correlation, and the widening rate of the breach was 3 to 8 times of the deepening rate, especially in the middle of the dam break, widening behavior occupied the dominant factor. The shape of the dam body after failure was parabolic, and the dam body had obvious elevation changes. These results provide the theoretical guidance and engineering application value for improving the theory and early warning model of the upstream tailing dam.
MOT: a Multi-Omics Transformer for multiclass classification tumour types predictions
Authors: Osseni Mazid Abiodoun , Tossou Prudencio , Laviolette Francois , Corbeil Jacques 
Published: November 2022

Abstract
Motivation: Breakthroughs in high-throughput technologies and machine learning methods have enabled the shift towards multi-omics modeling as the preferred mean to understand the mechanisms underlying biological processes, and to improve complex disease prognosis in clinical settings. However, most multi-omic studies only use transcriptomics and epigenomics due to their over-representation in databases and their early technical maturity compared to others omics. For complex phenotypes and mechanisms, not leveraging all the omics despite their varying degree of availability can lead to a failure to understand the underlying biological mechanisms.
Results: We proposed MOT (Multi-Omic Transformer), a deep learning based model using the transformer architecture, that discriminates complex phenotypes (herein cancers types) based on five omics data type regardless of their availability: transcriptomics (mRNA and miRNA), epigenomics (DNA methylation), copy number variations (CNVs), and proteomics. At its core, MOT uses a data augmentation scheme that allows it to handle missing omics views and its attention layers give a macro level of interpretability for each phenotypes. Indeed, MOT identifies the required omic type for the best prediction for each phenotype and therefore could guide clinical decision making when acquiring data to confirm a diagnostic. It achieves an accuracy score of 96.04% after 5-fold cross-validation among 33 tumour types. The newly introduced model can integrate and analyse five different omics data while handling the missing omics views and can also identify the essential omics data for the tumour multiclass classification tasks.
Availability and implementation: MOT source code is available at https://github.com/dizam92/multiomic_predictions.
CO Gas sensing properties of Pd- and Al-doped zinc oxide nanotube: A DFT study
Authors: Tohidi Somayeh , Sattarian Hossein , Tohidi Tavakkol 
Published: November 2022

Abstract
Surface engineering and doping of zinc oxide (ZnO) nanoparticles have been two feasible techniques for improving the gas-detecting capability of these nanoparticles. However, the role of fundamental processes and factors that affect this improvement has not been fully understood. In this study, the adsorption of CO gas molecules on Pd- and Al-doped ZnO nanotubes was investigated using the first-principles calculations. The binding strength and charge transport and structural properties of these nanotubes, were studied. The CO gas molecule was strongly chemisorbed onto the Pd- and Al-doped ZnO nanotubes with a high adsorption energy of −1.36 and -1.21 eV, respectively. Finally, in order to further understand the interaction between CO gas molecule and Pd- and Al-doped ZnO nanotubes, the density of states (DOS) and the partial density of states (PDOS) of Pd- and Al-doped ZnO nanotubes before and after CO adsorption were investigated. The results provided a better atomistic insight and a more comprehensive explanation of the improvements in electrical properties and sensing capabilities of Pd- and Al-doped ZnO.
Willingness to pay (WTP) for HIV and AIDS services in Africa: A systematic review
Authors: Byabagambi John Bekiita , Limmer Mark , Hollingsworth Bruce 
Published: November 2022

Abstract
Background: While Africa is the continent most affected by HIV and AIDS, its response to HIV and AIDS remains largely donor supported. However, in the face of declining donor support, alternative ways to sustainably support HIV and AIDS responses in Africa are paramount. This systematic review explores the willingness to pay (WTP) for HIV services in Africa as a potentially more sustainable HIV and AIDS service cost recovery approach.
Methods: A comprehensive systematic search for literature was conducted in electronic databases and websites of HIV and AIDS organisations for studies that reported on the willingness to pay for HIV services in Africa. Preference studies that did not use the WTP approach and that were conducted outside Africa were excluded. Information on the HIV service, the methods used in the studies and factors that influence WTP were extracted. A descriptive thematic analysis was undertaken. The findings are summarised in tables and graphs.
Results: A total of 5,139 records were returned and screened for eligibility from the initial search. After screening and removal of duplicates, twenty-two articles from 10 countries with 19,611 study participants were included in the final review. There is an uneven distribution of WTP studies across different types of HIV services and across countries. There is evidence of a willingness to pay for HIV services, with the proportion of people reported in individual studies that are willing to pay, ranging from 34.3% to 97.1%. However, inthe majority of studies (71.4%, 15/21), the amount people are willing to pay cannot cover the cost of the full service in an open market. Factors associated with WTP include socioeconomic status, beliefs, and knowledge about HIV services.
Conclusion: The current systematic review presents evidence of cost recovery from HIV programs. The main finding is that other resources, beyond out-of-pocket payments, are needed to meet the full cost of any service. This has implications for the provision of (nondonor-funded) services on a sustainable level in the long term.
Systematic review registration: PROSPERO, registration number CRD42021275215
Thiols as a Marker of Inflammatory Bowel Disease Activity: A Systematic Review with Meta-analysis
Authors: Passos Rebeca Araujo , Costa Priscila Ribas Farias , Lima Claudia Feio da Maia , Santana George Mariane Soares , David Victor , Santos Geisa de Jesus , Zaltman Cyrla , Soares-Mota Marcia , Rocha Raquel 
Published: November 2022

Abstract
Background
Evidence indicates that inflammation in Inflammatory Bowel Disease (IBD) is associated with increased systemic levels of reactive oxygen species. Systemic oxidative stress has been associated with reduced levels of plasma thiols. Less invasive tests capable of reflecting and predicting IBD activity are increasingly sought after. In this sense, we sought to systematically review the evidence inherent in serum thiol levels as a marker of Crohn's Disease and Ulcerative Colitis activity (PROSPERO: CRD42021255521).
Methods
The highest quality documents for systematic reviews and meta-analyses standards were used as reference. The highest quality documents for systematic reviews and meta-analyses standards were used as reference. Articles were searched on Medline via PubMed and via Central, VHL, LILACS, WOS, EMBASE, SCOPUS, COCHRANE, CINAHL, OVID, CTGOV, WHO/ICTRP, OPENGREY, BDTD and CAPES, between August and September/2021. Descriptors were defined according to the Medical Subject Heading.The articles were searched between August and September/2021. Of the 11 articles selected for full reading, 7 were included in the review. Of these, 4 were combinable studies and were included in the meta-analysis.
Results
The findings of the individual studies included suggest an association between disease activity and systemic oxidation, as measured by serum thiol levels, however, the pooled analysis did not identify a significant association between the parameters evaluated. The limitations identified in this meta-analysis made it impossible to weigh the results of individual studies, which, associated with potential confounding factors, may have interfered with the results of the grouped assessment.
Conclusions
We recommend conducting randomized clinical trials, with individuals of both phenotypes and in different stages of IBD, involving larger numbers of participants, using standardization of the technique for measuring serum thiols, in order to confirm whether thiols can be a good parameter of monitoring the clinical course of these intestinal diseases and the degree of clinical applicability.
Soil microbiological indicators in Coffea arabica crops under different weed management strategies
Authors: Zaidan Úrsula Ramos , Costa Maurício Dutra , Santos Ricardo Henrique Silva , de Matos Christiano da Conceição , de Freitas Francisco Cláudio Lopes 
Published: November 2022

Abstract
Microbiological variables can be sensitive indicators of changes in the physicochemical properties of soils resulting from disturbances caused by practices of weed management. The objective of this work was to evaluate the impact of weed management strategies on the soil, using microbiological indicators over four-year time measures (two in the dry and two during the rainy weather season). The experiment was carried out in a coffee plantation field (Coffea arabica), in a randomized block design with five treatments. The treatments corresponded to the cultivation of Urochloa ruziziensis and Pueraria phaseoloides managed by mowing, maintenance of spontaneous vegetation and control by mowing, control of spontaneous vegetation by application of herbicides (glyphosate or glyphosate + 2,4-D), and manual weeding using a hoe to maintain the soil without vegetation cover. Soil C – CO2 evolution, basal respiration (RR), biomass carbon (Cbio), and metabolic quotient (qCO2) were evaluated. Treatments with U. ruziziensis and P. phaseoloides presented lower qCO2 values, indicating more stable systems and closer to equilibrium. Cbio was higher in the treatment with P. phaseoloides, indicating better soil fertility and carbon input conditions. The microbiological indicators allowed us to conclude that management methods that form a cover over the soil favor the maintenance of soil quality and the sustainability of the system.