bluuebunny/crossref_metadata_2025_split huggingface dataset:
An improved local oscillator modulation of modulated sampling scheme for multiple mono-pulse radar signals reconstruction
Authors: Qiu Zhaoyang , Sun Minhong , Zhu Jun , Teng Xuyang , Song Huina 
Published: March 2022

AbstractThe modulated sampling scheme can intercept noncooperative signals distributed in a wide frequency band by using a single receiving channel, which is an efficient architecture in many radar and communication applications. The modulated sampling scheme employs a non-uniform sample pulse train to fold the intercepted signal prior to quantization/digitization by using a local oscillator (LO) that contains a certain modulation type. Since the mono-pulse radar signals are widely used in many radar systems, the modulated sampling scheme will receive the multiple mono-pulse radar signals simultaneously in dense signal environment, and the folded outputs of the modulated sampling scheme may meet frequency aliasing. Thus, it is necessary to investigate the reconstruction of the multiple mono-pulse signals intercepted by the modulated sampling scheme in the frequency aliasing situation. In this paper, based on the orthogonal matching pursuit algorithm, the LO modulation type of the modulated sampling scheme is analyzed to achieve a better reconstruction performance of the multiple mono-pulse signals. The drawback of the typical LO using sinusoidal frequency modulation to reconstruct multiple mono-pulse signals is investigated firstly. Then, an improved LO using periodic linear frequency modulation is proposed, and its effectiveness to reconstruct multiple mono-pulse signals is analyzed. Furthermore, the parameter setting criterion of the improved LO modulation is given, and the comparison using other modulation types is discussed. Finally, several simulations are conducted to prove our analysis and the improved LO modulation can reconstruct multiple mono-pulse signals under the frequency aliasing condition.
Adaptive response maps fusion of correlation filters with anti-occlusion mechanism for visual object tracking
Authors: Zhang Jianming , Liu Hehua , He Yaoqi , Kuang Li-Dan , Chen Xi 
Published: March 2022

AbstractDespite the impressive performance of correlation filter-based trackers in terms of robustness and accuracy, the trackers have room for improvement. The majority of existing trackers use a single feature or fixed fusion weights, which makes it possible for tracking to fail in the case of deformation or severe occlusion. In this paper, we propose a multi-feature response map adaptive fusion strategy based on the consistency of individual features and fused feature. It is able to improve the robustness and accuracy by building the better object appearance model. Moreover, since the response map has multiple local peaks when the target is occluded, we propose an anti-occlusion mechanism. Specifically, if the nonmaximal local peak is satisfied with our proposed conditions, we generate a new response map which is obtained by moving the center of the region of interest to the nonmaximal local peak position of the response map and re-extracting features. We then select the response map with the largest response value as the final response map. This proposed anti-occlusion mechanism can effectively cope with the problem of tracking failure caused by occlusion. Finally, by adjusting the learning rate in different scenes, we designed a high-confidence model update strategy to deal with the problem of model pollution. Besides, we conducted experiments on OTB2013, OTB2015, TC128 and UAV123 datasets and compared them with the current state-of-the-art algorithms, and the proposed algorithms have impressive advantages in terms of accuracy and robustness.
Immunotherapy for Alzheimer’s disease: targeting β-amyloid and beyond
Authors: Song Chenghuan , Shi Jiyun , Zhang Pingao , Zhang Yongfang , Xu Jianrong , Zhao Lanxue , Zhang Rui , Wang Hao , Chen Hongzhuan 
Published: March 2022

AbstractAlzheimer’s disease (AD) is the most common neurodegenerative disease in the elderly worldwide. However, the complexity of AD pathogenesis leads to discrepancies in the understanding of this disease, and may be the main reason for the failure of AD drug development. Fortunately, many ongoing preclinical and clinical studies will continually open up avenues to unravel disease mechanisms and guide strategies for AD diagnosis and drug development. For example, immunotherapeutic strategies targeting amyloid-β (Aβ) and tau proteins were once deemed almost certainly effective in clinical treatment due to the excellent preclinical results. However, the repeated failures of clinical trials on vaccines and humanized anti-Aβ and anti-tau monoclonal antibodies have resulted in doubts on this strategy. Recently, a new anti-Aβ monoclonal antibody (Aducanumab) has been approved by the US Food and Drug Administration, which brings us back to the realization that immunotherapy strategies targeting Aβ may be still promising. Meanwhile, immunotherapies based on other targets such as tau, microglia and gut-brain axis are also under development. Further research is still needed to clarify the forms and epitopes of targeted proteins to improve the accuracy and effectiveness of immunotherapeutic drugs. In this review, we focus on the immunotherapies based on Aβ, tau and microglia and their mechanisms of action in AD. In addition, we present up-to-date advances and future perspectives on immunotherapeutic strategies for AD.
Cost-effectiveness analysis on COVID-19 surveillance strategy of large-scale sports competition
Authors: Wang Xuechun , Cai Yiru , Zhang Bo , Zhang Xiangyu , Wang Lianhao , Yan Xiangyu , Zhao Mingchen , Zhang Yuan , Jia Zhongwei 
Published: March 2022

AbstractBackgroundNucleic acid test (NAT) could effectively control the spread of COVID-19 caused by large-scale sports competitions. However, quantitative analysis on the appropriate frequency of NAT is scarce, and the cost-effectiveness and necessity of high-frequency NAT remain to be fully explored and validated. This study aims to optimize the COVID-19 surveillance strategies through cost-effectiveness analysis for the Tokyo 2020 Olympic Games and the upcoming Beijing 2022 Olympic Winter Games.MethodsA total of 18 scenarios were designed regarding the NAT frequency, symptom monitoring, and strengthening close-contact control. An agent-based stochastic dynamic model was used to compare the cost-effectiveness of different NAT scenarios and optimize the surveillance strategies. The dynamics of the proposed model included the arrival and departure of agents, transmission of the disease according to Poisson processes, and quarantine of agents based on regular NATs and symptom onset. Accumulative infections, cost, and incremental cost-effectiveness ratio (ICER) were simulated in the frame of the model. ICER was used to compare the cost-effectiveness of different scenarios. Univariate sensitivity analysis was performed to test the robustness of the results.ResultsIn Scenario 16, where the competition-related personnel (CRP) received NAT daily and national sports delegation (NSD) with quarantined infections accepted an additional NAT daily, accumulative infection was 320.90 (90 initial infections), the total cost was (United States Dollar) USD 8 920 000, and the cost of detecting out each infection was USD 27 800. Scenario 16 would reduce the total cost by USD 22 570 000 (avoid 569.61 infections), USD 1 420 000 (avoid 47.2 infections) compared with Scenario 10 (weekly NAT, strengthened close contact control) and Scenario 7 (daily NAT, no strengthened close contact control), respectively. Sensitivity analysis showed that the result was most sensitive to the change in basic reproductive number.ConclusionsHigh-frequency NATs such as bidaily, daily, and twice a day were cost-effective. NAT daily for CRP with strengthening close-contact control could be prioritized in defense against COVID-19 at large-scale sports competitions. This study could assist policymakers by assessing the cost-effectiveness of NAT scenarios and provide the host country with an optimal COVID-19 surveillance strategy.Graphical Abstract
A nationwide cross-sectional study of workers’ mental health during the COVID-19 pandemic: Impact of changes in working conditions, financial hardships, psychological detachment from work and work-family interface
Authors: Trógolo Mario Alberto , Moretti Luciana Sofía , Medrano Leonardo Adrián 
Published: March 2022

Abstract
Background
The COVID-19 disease has changed people’s work and income. While recent evidence has documented the adverse impact of these changes on mental health outcomes, most research is focused on frontline healthcare workers and the reported association between income loss and mental health comes from high-income countries. In this study we examine the impact of changes in working conditions and income loss related to the COVID-19 lockdown on workers’ mental health in Argentina. We also explore the role of psychological detachment from work and work-family interaction in mental health.

Methods
A total of 1049 participants aged between 18 and 65 who were working before the national lockdown in March 2020 were recruited using a national random telephone survey. Work conditions included: working at the usual workplace during the pandemic, working from home with flexible or fixed schedules, and being unemployed or unable to work due to the pandemic. Measures of financial hardship included income loss and self-reported financial problems related to the outbreak. Work-family interface included measures of work-family conflict (WFC) and family-work conflict (FWC). Mental health outcomes included burnout, life satisfaction, anxiety and depressive symptoms. Data were collected in October 2020.

Results
Home-based telework under fixed schedules and unemployment impact negatively on mental health. Income loss and particularly self-reported financial problems were also associated with deterioration of mental health. More than half of the participants reported financial problems, and those who became unemployed during the pandemic experienced more often financial problems. Finally, psychological detachment from work positively influenced mental health; WFC and FWC were found to negatively impact on mental health.

Conclusions
Countries’ policies should focus on supporting workers facing economic hardships and unemployment to ameliorate the COVID-19’ negative impact on mental health. Organisations can protect employees’ mental health by actively encouraging psychological detachment from work and by help managing work-family interface. Longitudinal studies are needed to more thoroughly assess the long-term impact of the COVID-19-related changes in work and economic turndown on mental health issues.
CAR-NK cells for cancer immunotherapy: from bench to bedside
Authors: Zhang Leisheng , Meng Yuan , Feng Xiaoming , Han Zhongchao 
Published: March 2022

AbstractNatural killer (NK) cells are unique innate immune cells and manifest rapid and potent cytotoxicity for cancer immunotherapy and pathogen removal without the requirement of prior sensitization or recognition of peptide antigens. Distinguish from the T lymphocyte-based cythotherapy with toxic side effects, chimeric antigen receptor-transduced NK (CAR-NK) cells are adequate to simultaneously improve efficacy and control adverse effects including acute cytokine release syndrome (CRS), neurotoxicity and graft-versus-host disease (GVHD). Moreover, considering the inherent properties of NK cells, the CAR-NK cells are “off-the-shelf” product satisfying the clinical demand for large-scale manufacture for cancer immunotherapy attribute to the cytotoxic effect via both NK cell receptor-dependent and CAR-dependent signaling cascades. In this review, we mainly focus on the latest updates of CAR-NK cell-based tactics, together with the opportunities and challenges for cancer immunotherapies, which represent the paradigm for boosting the immune system to enhance antitumor responses and ultimately eliminate malignancies. Collectively, we summarize and highlight the auspicious improvement in CAR-NK cells and will benefit the large-scale preclinical and clinical investigations in adoptive immunotherapy.
An approach for the reconstruction of a traditional masonry-wooden building located in an archeological area. Part I: Methodology
Authors: Akcay Cemil , Korkmaz Nail Mahir , Sayin Baris 
Published: March 2022

Abstract
This study, presented in a pair of articles, defines a comprehensive methodological approach to the reconstruction of a traditional masonry-timber mansion building constructed in the 1880s of the Turkish house typology on Istanbul’s historical peninsula area that was intentionally demolished in 1948. A historical process research was carried out in the first stage of the study, after which ground penetration radar measurements and an archeological excavation were carried out to determine any possible remains or ruins of the structure, and the original architectural features of the demolished building were ascertained from the obtained data. The proposed stages in the current paper can be considered a comprehensive approach to the determination of the authentic properties of demolished or destroyed buildings in historical areas, given that the methodology allows for the integration of construction features obtained separately and independently through different activities, such as excavations, georadar measurements and historical surveys. The result is a versatile approach to the complete and realistic reconstruction of historical buildings.
Current status of palliative care delivery and self-reported practice in ICUs in Japan: a nationwide cross-sectional survey of physician directors
Authors: Igarashi Yuko , Tanaka Yuta , Ito Kaori , Miyashita Mitsunori , Kinoshita Satomi , Kato Akane , Kizawa Yoshiyuki 
Published: March 2022

Abstract
Background
It is currently unknown how widespread is the practice of palliative care in intensive care units (ICUs) in Japan. This study aimed to determine evaluate the delivery and self-reported practice of palliative care in ICUs in Japan.

Methods
A self-administered questionnaire was sent to the physician directors of all 873 ICUs in Japan in August 2020.

Results
Of the 873 institutions, 439 responded the questionnaire (response rate: 50%) and 413 responses were included in the analysis. The responding physicians thought palliative care was appropriate for physical symptoms (36%, 95% Confidence Interval [CI] 32–41), the provision of information (32%, 95% CI: 28–37), psychological distress (25%, 95% CI: 21–29) and in Post Intensive Care Syndrome (PICS) prevention (20%, 95% CI: 17–24). Only 4% (95% CI: 2–6) of participants indicated that they always provided palliative care screening for the patients admitted to the ICU. The most common method to determine eligibility for palliative care was the “prediction of prognosis by clinician’s experience” (54%, 95% CI: 50–59). Thirty-one percent (95% CI: 27–36) of participants responded that there was no clear method used to decide which patients need palliative care. Fifty-four percent of the participants answered they had no standardized protocols for symptom management at all. Less than 5% answered they had standardized protocols for end-of-life symptom management or terminal weaning off mechanical ventilation including extubation of endotracheal tubes.

Conclusions
In Japan, the dissemination of palliative care and its integration into ICU care appears insufficient. To improve the quality of life of patients who are admitted to ICU, it may be useful to implement palliative care screening and multidisciplinary conferences, to develop standardized protocols for symptom management and withholding or withdrawing of life-sustaining treatment, and to educate primary palliative care for all ICU physicians.
Multi-tracer and multiparametric PET imaging to detect the IDH mutation in glioma: a preclinical translational in vitro, in vivo, and ex vivo study
Authors: Clément Alexandra , Zaragori Timothee , Filosa Romain , Ovdiichuk Olga , Beaumont Marine , Collet Charlotte , Roeder Emilie , Martin Baptiste , Maskali Fatiha , Barberi-Heyob Muriel , Pouget Celso , Doyen Matthieu , Verger Antoine 
Published: March 2022

Abstract
Background
This translational study explores multi-tracer PET imaging for the non-invasive detection of the IDH1 mutation which is a positive prognostic factor in glioma.

Methods
U87 human high-grade glioma (HGG) isogenic cell lines with or without the IDH1 mutation (CRISP/Cas9 method) were stereotactically grafted into rat brains, and examined, in vitro, in vivo and ex vivo. PET imaging sessions, with radiotracers specific for glycolytic metabolism ([18F]FDG), amino acid metabolism ([18F]FDopa), and inflammation ([18F]DPA-714), were performed sequentially during 3–4 days. The in vitro radiotracer uptake was expressed as percent per million cells. For each radiotracer examined in vivo, static analyses included the maximal and mean tumor-to-background ratio (TBRmax and TBRmean) and metabolic tumor volume (MTV). Dynamic analyses included the distribution volume ratio (DVR) and the relative residence time (RRT) extracted from a reference Logan model. Ex vivo analyses consisted of immunological analyses.

Results
In vitro, IDH1+ cells (i.e. cells expressing the IDH1 mutation) showed lower levels of [18F]DPA-714 uptake compared to IDH1- cells (p < 0.01). These results were confirmed in vivo with lower [18F]DPA-714 uptake in IDH+ tumors (3.90 versus 5.52 for TBRmax, p = 0.03). Different values of [18F]DPA-714 and [18F] FDopa RRT (respectively 11.07 versus 22.33 and 2.69 versus − 1.81 for IDH+ and IDH- tumors, p < 0.02) were also observed between the two types of tumors. RRT [18F]DPA-714 provided the best diagnostic performance to discriminate between the two cell lines (AUC of 100%, p < 0.01). Immuno-histological analyses revealed lower expression of Iba-1 and TSPO antibodies in IDH1+ tumors.

Conclusions
[18F]DPA-714 and [18F] FDopa both correlate with the presence of the IDH1 mutation in HGG. These radiotracers are therefore good candidates for translational studies investigating their clinical applications in patients.
Investigation of a new modulated aperture using speckle techniques
Authors: Hamed A. M. 
Published: March 2022

Abstract
Background
A design of equally spaced eight-circles placed at equal distances from the origin is suggested. Three models corresponding to the eight-circle design considering conic, linear, and quadratic distributions are investigated. This arrangement is considered for the sake of improving both microscope resolution and image contrast as compared with the pure annular aperture. This design is different compared with other recent work on aperture modulation.

Results and discussions
The point spread function (PSF) is computed in all the models using the fast Fourier transform (FFT) algorithm that computes the discrete Fourier transform (DFT) corresponding to the models and compared with the corresponding PSF in the case of uniform circular aperture. In addition, the autocorrelation images for the apertures are shown differently. It is shown smooth pattern for the circular arrangement as compared with the deformation and shrinking appeared in the central peak in case of conic model. Finally, the speckle images corresponding to the considered apertures are investigated. Reconstructed apertures are obtained from the speckle images using the FFT algorithm.

Conclusions
The PSF is computed for the described models, and the autocorrelation corresponding to the apertures showed difference. The reconstructed apertures from the speckle images can be improved using filtering techniques. It is noted that MATLAB codes are constructed in the computations of all images and plots.
The efficacy and safety of niacin on hyperphosphatemia in ESRD patients undergoing hemodialysis: randomized controlled trial
Authors: Ahmed Hanan Mahmoud , Yossif Esraa , Abd-Elkader Alaa S. , Abdel Aziz Essam M. 
Published: March 2022

Abstract
Background
Hyperphosphatemia is a common complication of end-stage renal disease (ESRD) and particularly affects hemodialysis (HD) patients. Elevated serum phosphorus contributes to the development of secondary hyperparathyroidism, chronic kidney disease–mineral bone disorder (CKD-MBD), metastatic calcifications and calcific uremic arteriolopathy. There is a significant association between hyperphosphatemia and increased morbidity and mortality in ESRD patients including cardiovascular morbidity and mortality, and it is also associated with prolonged hospitalization of HD patients. This study aim to evaluate the serum phosphorus lowering effect of niacin in HD patients.

Results
There was a decrease in phosphate values during the first 3 months of the study in the niacin group, with a significant change in phosphate level at the third month (5.90 ± 0.52 vs. 6.42 ± 0.65 (mEq/l); P <  0.001) and at the sixth month (5.12 ± 0.41 vs. 5.76 ± 0.47 (mEq/l); P <  0.001) compared to the control group. It was noted that both groups had an insignificant difference regarding baseline parathormone (PTH), though the PTH showed a significantly lower level at the third month (192.39 ± 78.85 vs. 388.27 ± 263.10 pg/ml; P <  0.001) and at the sixth month (127.56 ± 90.87 vs. 249.85 ± 97.69 pg/ml; P <  0.001) in the niacin group.

Conclusion
Niacin caused a statistically significant decrease in levels of phosphate and PTH in dialysis patients.

Trial registration
Registered at ClinicalTrials.gov NCT03163576. Trial registration date: 22 May 2017. Date of first patient’s enrolment: 1 October 2018. Date of the ethical committee approval: 29 March 2017. Number of the ethical committee approval: 17100040.
Autoimmune encephalitis as a complication of COVID-19 infection: a case report
Authors: Dahshan Ahmed , Abdellatef Abeer Awad 
Published: March 2022

Abstract
Background
During COVID-19 pandemic, a lot of newly discovered symptoms and presentations are emerging. Neurological symptoms of corona virus disease 19 (COVID19) have been reported including central nervous symptoms (CNS), peripheral nervous symptoms (PNS), and skeletal muscular symptoms; however, data are scarce about the exact occurrence of neurological affection during COVID-19 infection.

Case presentation
We present a case of a 67-year-old male patient with proven COVID-19 infection who developed acute confusion state, behavioral changes, agitation, and one attack of loss of consciousness 8 days following the infection. Laboratory profile, computed tomography (CT) brain, magnetic resonance imaging (MRI), and cerebrospinal fluid (CSF) analysis all were normal, and the patients were highly suspicion of autoimmune encephalitis due to COVID-19 infection. The patient received pulse steroid therapy with complete regaining the conscious level.

Conclusion
This clinical case emphasizes the possible relationship between COVID-19 infection and autoimmune encephalitis.