bluuebunny/crossref_metadata_2025_split huggingface dataset:
The level of development of dexterity in applicants for higher education of the I–IV courses
Authors: Bakanova O. 
Published: April 2022

The article highlights the role of the agility in human life, reveals the essence and the features of development of this physical quality. The indicators of the dexterity development in applicants for higher education of the I–IV courses of the university, which were determined by the results of the «shuttle» run 4×9 m, are considered. A comparative analysis of the indicators of the studied physical quality in boys and girls depending on age and sex is given.
The study was conducted in September 2021 on the basis of the National Aerospace University «Kharkiv Aviation Institute». It was attended by 468 applicants for higher education of the I-IV courses, who are 17–20 years old. In the І course studied applicants for higher education, who were 17 years old, in the IІ course – 18 years old, in the IIІ course – 19 years old and in the ІV course – 20 years old. The applicants for higher education voluntarily participated in the study, about the specifics of which they were informed. To achieve the goal of the study, the following methods were used: theoretical analysis and generalization of the scientific and the methodological literature, the pedagogical testing and methods of the mathematical statistics. It was found that the best results of the «shuttle» run 4×9 m were recorded in boys and girls of the first year, who are 17 years old. A comparison of the dexterity indicators in applicants for higher education I-IV courses of the university on the basis of gender showed that they are better in boys than in girls. The age dynamics of the indicators in this contingent with age is increases, which indicates the deterioration of the studied results. It has been established that applicants for higher education of the I–IV courses have a low level of dexterity development.
Formation of professional mobility of future specialists in the sphere of physical culture and sport in the course of internship
Authors: Kvasnytsia Oleh , Kvasnytsia Iryna , Flerchuk Viktor 
Published: April 2022

The article reveals methodological basis of professional mobility formation of future specialists in physical culture and sport during their internship providing personal preparedness to effective adaptation to the demands of present-day labor market, professional activity and shifts within social and professional fields. The authors have revealed that under conditions of labor market, professional education promotes establishment of person’s competiveness only in case of formation of his/her professional mobility, topicality of which is primarily related to social demand. To reveal basic drawbacks of professional preparedness of future specialists in physical culture and sport in higher educational establishments and the issues of formation of their professional mobility, polling and questioning of coaches in kinds of sports in various categories qualifications in Children’s and Youth Sports Schools of Khmelnytskyi and Khmelnytskyi oblast school of higher sports mastery were done.
The notion of “professional mobility of a specialist in physical culture and sport” has been revealed. It has been determined that engaging students in practical activity is an important condition for the formation of the aforementioned quality of students in higher educational establishments. This way students shift their position: from being the object of education to subject of self-realization. Types of internship have been outlined, organizational conditions and factors that promote students’ positive motivation to acquisition of professional mobility have been specified, namely: realization of ultimate aims of education, theoretical and practical value of the acquired knowledge; demonstration of future professional perspectives during internship; professional orientation of educational activity; tackling of problem situations occurring in the process of professional activity. It has been revealed that that in the course of internship, it is possible to form such integrative quality of a person as professional mobility, which allows future specialists in physical culture and sport to learn adjacent types of professional activity quickly and thoroughly and envisages preparedness to quick adaptation on present-day labor market and employment which provide competitiveness of future specialists.
Theoretical substantiation of the program of special physical training of high school students at the educational level "master"
Authors: Otkydach V.S. 
Published: April 2022

A preliminary analysis of the physical training of cadets of higher military educational institutions showed that training programs for military professionals in physical education, special physical training need radical changes. This is due to the participation of the Armed Forces of Ukraine in hostilities - the model and practicality of approaches to hostilities have changed dramatically, the conditions of preparation for them require the introduction of military-applied sports in the training process of military professionals. The professional activity of servicemen is accompanied by maximum physical and mental loads in terms of volume and intensity, complexity and variety of tasks in the conditions of lack of time and information, constant risk and threat to life.
The current program of training future military professionals at the "master's" level to some extent does not meet these requirements for the formation of psychophysical readiness of future officers. This was shown by the participation in the joint forces operation (anti-terrorist operation) in eastern Ukraine, a large number of wounded and killed servicemen during the fighting. Foreign and domestic experts who assessed the conflict came to the conclusion that the servicemen of the Armed Forces of Ukraine were not ready to use weapons in the Republic of Crimea, Donetsk and Luhansk regions during the first stage of the armed conflict.
پاکستان کے اسلامی مدارس میں تعلیم وتربیت کے اسالیب کا تحقیقی وتنقیدی جائزہ
Authors: Muhammad Waris  , Farooq Muhammad Ajmal 
Published: April 2022

The Madrasa is the source of knowledge and wisdom from which the passengers of the colorful world bloom who, after being irrigated with the holy chapter of knowledge, decides to camphor the darkness of barbarity from the world. Then the light creatures are on the floor in their path. The teacher is a mirror of a great position. The holy prophet said, "I am a teacher. Allah Almighty has sent me as a teacher." The purpose of which is to adorn the servants of God with the adornment of education, to become a practical example of my eyes are bright, my heart is happy. And Allah’s Messenger (peace and blessings of Allah be upon him) said: He recites and incarcerates them and teaches them the Book and Wisdom, even though they were in clear error before this. This is the same school of prophecy about which Iqbal said: it was the miracle of the school and its training, who taught Ismail the good manners.
Key Words: Pakistan, Education, Madāris, Islamic Knowledge, Research, Training,
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUH NASABAH MELAKUKAN DEPOSITO MUDHARABAHPADA BANK ACEH SYARIAH CABANG PEMBANTU IDI RAYEUK
Authors: Febi Febi , Dayyan Muhammad , Kismawadi Early Ridho , Muliana Muliana 
Published: April 2022

AbstractThis study aims to determine the factors that affect customers to deposit mudharabah at Aceh Sharia Bank Idi Rayeuk Branch and to determine the partial and simultaneous effect on interest in mudharabah deposits. There are several factors that influence customers in performing mudharabah deposits such as the influence of profit sharing factors, service factors and promotion factors. This study is quantitative study, using 81 respondents as research sample. Sampling in this research is done by probability sampling with Random sampling method, that sample selection technique without considering the level that exist in that population. Data collection techniques using questionnaires as many as 41 items of questions assessed by the likert scale 1-5 and tested its feasibility using the validity and realiability test. The collected data were classical assumption test including multicolinearity test, heterokedasticity, normality, autocorrelation and linearity. To analysis data using multiple regression with determination test method, F test and t test. Based on multiple regression analysis at significance level 5% showed that simultaneously factor of profit sharing, service factor and promotion factor have a significant positive effect to make decision to do mudharabah deposit. The results also show partially that (1) there is a significant positive effect of profit sharing factor to make decision to do deposit mudharabah at Aceh Sharia Bank Idi Rayeuk Branch; (2) there is a significant positive effect of service factor to make decision to do deposit mudharabah at Aceh Sharia Bank Idi Rayeuk Branch; and (3) there is a significant negative effect of profit sharing factor to make decision to do deposit mudharabah at Aceh Sharia Bank Idi Rayeuk Branch. The service factor variable has the most dominant influence with significance (0,000 <0.05) and tcount> ttable (4,518> 1,991).
IMPLEMENTASI MARKETING MIX DALAM UPAYA KEMAJUAN USAHA BUTIK MUSLIMAH DI KOTA LANGSA
Authors: Febi Febi , Rizal Syamsul , Astina Chahayu , Fajri Nurul 
Published: April 2022

Aceh, as the province that became the pioneer of the implementation of Islamic Sharia in Indonesia. The need for Muslim dress or muslimah is an absolutely necessary thing. The need for Muslim clothing for the community encourages entrepreneurs to sell their best products are no exception with boutique entrepreneurs, especially in the city directly. Universally, goods sold in boutiques are very rare or even never found in ordinary stores. All that can not be separated because the boutique has a philosophy on the clothing items are exclusive, elite, fashionable and sophisticated fashion and complete with accessories. As for the problems in this study are (1) how the business boutique Muslim Langsa City. (2) how is the implementation of marketing mix in the effort of progress of Muslim clothing boutique in Langsa City ?. Based on these problems, this study aims to determine the implementation of marketing mix in the effort of Muslim clothing business boutique in Langsa City. The research method that the writer use in this research are: qualitative descriptive ie presentation of research result through description of observation result, interview and documentation to see the implementation of marketing mix in effort of progress of boutique clothing fashion Muslim in Langsa City. Based on the results of research that: Muslim Boutique in Langsa City specialize marketing its products in some market segment especially for society which is Moslem, which 70% target is teenagers, the rest is public. In the implementation of marketing mix in the effort of progress of Muslim fashion boutique in Langsa City apply four elements, that is: products at Muslim Boutique in Langsa City focus on quality according to customer requirement that put forward kesyar'iannya. The pricing strategy determined by the Muslim Boutique in Langsa City is adjusted to total raw materials, production materials, all manufacturing costs are totaled and profitability of each product is taken at 40%. In the distribution strategy set the business near the city center, universities, companies, and government buildings city of Langsa City is not far from the crowd. Boutique Muslimah in Langsa City in the selection of promotion strategies Muslim Boutique in Langsa City has made various promotions including, personal selling, advertising, sale promotion and publicity.
La Problemática de la Conservación de los Recursos como Expresión Próxima del fin Último de la Perpetuidad del Poder en el Siglo XVII (Huancavelica, Perú, 1597-1645)
Authors: Pardo Jorge Alejandro Laris 
Published: April 2022

El propósito de este artículo es exponer en qué contexto semántico y con que propósito se usó el concepto “conservación” por los funcionarios de la Corona española en la minería americana de mercurio al comenzar el siglo XVII. El problema de la conservación de la salud de los trabajadores y los recursos naturales no es algo exclusivo de los últimos tres siglos. Se ha manifestado de manera distinta en diversos tiempos de acuerdo a los intereses e idiosincrasias del momento. En Occidente, estas preocupaciones tienen profundas raíces históricas. Con el fin de contribuir a su conocimiento, se ha dividido este trabajo en tres apartados, en el primero se presenta el contexto histórico de la mina de Huancavelica al comenzar el siglo XVII, el segundo continua esta exposición con un breve recorrido por la historia del Hospital Real de Huancavelica. Finalmente, en el tercer apartado se aborda de lleno el propósito que es demostrar que para la Corona, la conservación tenía un sentido eminentemente político, ligado a la perpetuidad de su poder en la zona.
Cendekiawan Heresiografi Awal dalam Perbandingan Agama: Muhammad ‘Abd Al-Karim Al-Shahrastani dan Kitabnya, Al-Milal Wa Al-Nihal
Authors: Sabjan Muhammad Azizan 
Published: April 2022

This study is an effort to highlight the views of one of the Islamic scholars who has contributed a lot of time and energy to studying the traditions of other religions. His name was Abū al-Fath Muhammad Ibn ‘Abdul al-Karīm Ahmad al-Shahrastānī (479/1086-548/1153). Thus, the study presented here is to look at the typological nature of religion as it has been developed exclusively by al-Shahrastānī. The focus of the writing is on how he classifies religious typologies and how he expresses and elaborates on such classifications in his masterpiece, al-Milal wa al-Nihal. This research employs a qualitative method by analyzing data descriptively. The finding of study found that the question of religious recognition and respect, as well as tolerance, can be observed from the concept of religious typology as established by al-Shahrastānī in his book, al-Milal wa al-Nihal.
ABSTRAK
Kajian ini merupakan satu usaha bagi mengetengahkan pandangan salah seorang cendekiawan Islam yang telah banyak memberikan sumbangan masa dan tenaga dalam mengkaji tradisi agama lain. Nama beliau adalah Abū al-Fath Muhammad Ibn ‘Abdul al-Karīm Ahmad al-Shahrastānī (479/1086-548/1153). Justeru, kajian yang dibentangkan ini adalah untuk melihat sifat tipologi agama seperti yang telah dibangunkan secara eksklusif oleh al-Shahrastānī. Fokus penulisan tertumpu kepada bagaimana beliau mengklasifikasikan tipologi agama dan bagaimana beliau menyatakan serta menghuraikan pengklasifikasian tersebut dalam karya agungnya, al-Milal wa al-Nihal. Diharapkan kajian ini dapat memberikan pemahaman dan pengkayaan wacana tentang konsep tipologi agama seperti yang telah dibentuk oleh al-Shahrastānī dalam kitabnya, al-Milal wa al-Nihal.
Reconstituting Microtubules: A Decades-Long Effort From Building Block Identification to the Generation of Recombinant α/β-Tubulin
Authors: Ti Shih-Chieh 
Published: April 2022

Microtubules are cytoskeletal filaments underlying the morphology and functions of all eukaryotic cells. In higher eukaryotes, the basic building blocks of these non-covalent polymers, ɑ- and β-tubulins, are encoded by expanded tubulin family genes (i.e., isotypes) at distinct loci in the genome. While ɑ/β-tubulin heterodimers have been isolated and examined for more than 50 years, how tubulin isotypes contribute to the microtubule organization and functions that support diverse cellular architectures remains a fundamental question. To address this knowledge gap, in vitro reconstitution of microtubules with purified ɑ/β-tubulin proteins has been employed for biochemical and biophysical characterization. These in vitro assays have provided mechanistic insights into the regulation of microtubule dynamics, stability, and interactions with other associated proteins. Here we survey the evolving strategies of generating purified ɑ/β-tubulin heterodimers and highlight the advances in tubulin protein biochemistry that shed light on the roles of tubulin isotypes in determining microtubule structures and properties.
3D Single Molecule Super-Resolution Microscopy of Whole Nuclear Lamina
Authors: Rozario Ashley M. , Morey Alison , Elliott Cade , Russ Brendan , Whelan Donna R. , Turner Stephen J. , Bell Toby D. M. 
Published: April 2022

Single molecule (SM) super-resolution microscopies bypass the diffraction limit of conventional optical techniques and provide excellent spatial resolutions in the tens of nanometers without overly complex microscope hardware. SM imaging using optical astigmatism is an efficient strategy for visualizing subcellular features in 3D with a z-range of up to ∼1 µm per acquisition. This approach however, places high demands on fluorophore brightness and photoswitching resilience meaning that imaging entire cell volumes in 3D using SM super-resolution remains challenging. Here we employ SM astigmatism together with multiplane acquisition to visualize the whole nuclear lamina of COS-7 and T cells in 3D. Nuclear lamina provides structural support to the nuclear envelope and participates in vital nuclear functions including internuclear transport, chromatin organization and gene regulation. Its position at the periphery of the nucleus provides a visible reference of the nuclear boundary and can be used to quantify the spatial distribution of intranuclear components such as histone modifications and transcription factors. We found Alexa Fluor 647, a popular photoswitchable fluorophore, remained viable for over an hour of continuous high laser power exposure, and provided sufficient brightness detectable up to 8 µm deep into a cell, allowing us to capture the entire nuclear lamina in 3D. Our approach provides sufficient super-resolution detail of nuclear lamina morphology to enable quantification of overall nuclear dimensions and local membrane features.
Hydrogenolysis of 5-Hydroxymethylfurfural to 2,5-Dimethylfuran Over a Modified CoAl-Hydrotalcite Catalyst
Authors: Xia Jing , Gao De , Han Feng , Lv Ruifu , Waterhouse Geoffrey I. N. , Li Yan 
Published: April 2022

The catalytic hydrogenolysis of 5-hydroxymethylfurfural (HMF) to 2,5-dimethylfuran (DMF) is a promising route towards sustainable liquid fuels with a high energy density. Herein, a novel CuCoNiAl-containing mixed metal oxide catalyst (CuCoNiAl-MMO) was prepared by calcination a layered double hydroxide (LDH) precursor in N2 at 500 °C, then applied for the catalytic hydrogenolysis of HMF to DMF. The effects of reaction time, reaction temperature and hydrogen pressure on DMF selectivity were investigated. Under relatively mild reaction conditions (180°C, 1.0 MPa H2, 6.0 h), CuCoNiAl-MMO showed both a high initial activity and selectivity for hydrogenolysis of HMF to DMF, with HMF conversion rate of 99.8% and DMF selectivity of 95.3%. Catalysts characterization studies using scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) revealed the presence of various metal oxides and metallic copper on the surface of the CuCoNiAl-MMO catalyst, with the presence of mixed metal-oxide-supported metallic Cu nanoparticles being responsible good hydrogenolysis activity of the catalyst for selective DMF synthesis.
The Significance of Symptoms in Predicting Coronary Artery Aneurysms of Kawasaki Disease, Especially in Female Patients
Authors: Yu Huan , Sun Weiyue , Wu Haoran , Zhang Shuchi , Xu Zhipeng , Wu Rongzhou , Rong Xing , Qiu Huixian , Zhu Jinshun , Zhang Chunxiang , Chu Maoping 
Published: April 2022

BackgroundKawasaki disease (KD) is an acute febrile systemic vasculitis of unknown etiology that occurs during early childhood, commonly involving the coronary artery, and can lead to coronary artery aneurysms (CAAs).MethodsThe demographic, clinical, and laboratory data of KD patients without coronary artery lesions (N-CAL) and with CAA were collected during 2005–2020 at the Second Affiliated Hospital of Wenzhou Medical University. The patients were divided into the development cohort and the validation cohort. First, we compared the general information, symptoms, and laboratory data of N-CAL and CAA patients in the development cohort and the total cohort and screened out the different indices by logistic regression analysis. Then, we established three models and compared the area under the curve (AUC) values of the receiver operating characteristic (ROC) curves to identify meaningful models for CAA, which were further verified by decision curve analysis (DCA). Second, taking into account previous reports on the importance of gender to CAA, gender stratification was conducted.ResultsThe analysis of clinical and blood indices revealed the following novel features: (i) Many factors were found to be related to CAA, including IVIG resistance and the symptoms of rash, oral changes, and cervical lymphadenopathy. (ii) The development cohort was analyzed by logistic regression, and three models were established. The ROC curves showed that Model 2, composed of IVIG resistance, rash, oral changes, and cervical lymphadenopathy, had a better AUC value and easily to evaluate in the prediction of CAA. (iii) The selected model for predicting CAA in the development cohort was further confirmed in the validation cohort through DCAs. (iv)We further compared the items enrolled in the three models above between the N-CAL and CAA groups by sex, and the results indicated that female KD patients without rash, oral changes, and cervical lymphadenopathy were more likely to develop CAA.ConclusionThe absence of rash, oral changes, and cervical lymphadenopathy are risk factors for CAA, especially in female KD patients. Accurately recognizing symptoms, early diagnosis, and standard treatment for KD are key to reducing the incidence of CAA.
Renal Denervation Attenuates Adverse Remodeling and Intramyocardial Inflammation in Acute Myocardial Infarction With Ischemia–Reperfusion Injury
Authors: Wang Kun , Qi Yu , Gu Rong , Dai Qing , Shan Anqi , Li Zhu , Gong Chenyi , Chang Lei , Hao Han , Duan Junfeng , Xu Jiamin , Hu Jiaxin , Mu Dan , Zhang Ning , Lu Jianrong , Wang Lian , Wu Han , Li Lixin , Kang Lina , Xu Biao 
Published: April 2022

BackgroundInhibition of sympathetic activity and renin–angiotensin system with renal denervation (RDN) was proved to be effective in managing refractory hypertension, and improving left ventricular (LV) performance in chronic heart failure. The inhibition of sustained sympathetic activation prevents or delays the development of cardiac fibrosis and dysfunction that occurs after myocardial infarction and ischemia–reperfusion (I/R) injury. The translational efficiency of RDN remains to be defined in preclinical animal studies.ObjectivesThis study investigated the therapeutic role of RDN in adverse remodeling and intramyocardial inflammation in myocardial ischemia–reperfusion (MI/R) injury.MethodsHerein, 15 minipigs were subjected to 90-min percutaneous occlusion of the left anterior descending artery followed by reperfusion. Eight animals received simultaneous RDN using catheter-based radiofrequency ablation (MI/R-RDN). Cardiac function and infarct volume were measured in vivo, followed by histological and biochemical analyses.ResultsThe infarct volume in I/R-RDN pigs reduced at 30 days postreperfusion, compared to I/R-Sham animals. The levels of catecholamine and cytokines in the serum, kidney cortex, the border, and infarcted regions of the heart were significantly reduced in I/R-RDN group. Moreover, the gene expression of collagen and the protein expression of adrenergic receptor beta 1 in heart were also decreased in I/R-RDN mice. Additionally, RDN therapy alleviated myocardial oxidative stress.ConclusionRDN is an effective therapeutic strategy for counteracting postreperfusion myocardial injury and dysfunction, and the application of RDN holds promising prospects in clinical practice.