bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wheat genome architecture influences interactions with phytobeneficial microbial functional groups in the rhizosphere
Authors: Gruet Cécile , Abrouk Danis , Börner Andreas , Muller Daniel , Moënne‐Loccoz Yvan 
Published: December 2022

AbstractWheat has undergone a complex evolutionary history, which led to allopolyploidization and the hexaploid bread wheat Triticum aestivum. However, the significance of wheat genomic architecture for beneficial plant–microbe interactions is poorly understood, especially from a functional standpoint. In this study, we tested the hypothesis that wheat genomic architecture was an overriding factor determining root recruitment of microorganisms with particular plant‐beneficial traits. We chose five wheat species representing genomic profiles AA (Triticum urartu), BB {SS} (Aegilops speltoides), DD (Aegilops tauschii), AABB (Triticum dicoccon) and AABBDD (Triticum aestivum) and assessed by quantitative polymerase chain reaction their ability to interact with free‐nitrogen fixers, 1‐aminocyclopropane‐1‐carboxylate deaminase producers, 2,4‐diacetylphloroglucinol producers and auxin producers via the phenylpyruvate decarboxylase pathway, in combination with Illumina MiSeq metabarcoding analysis of N fixers (and of the total bacterial community). We found that the abundance of the microbial functional groups could fluctuate according to wheat genomic profile, as did the total bacterial abundance. N fixer diversity and total bacterial diversity were also influenced significantly by wheat genomic profile. Often, rather similar results were obtained for genomes DD (Ae. tauschii) and AABBDD (T. aestivum), pointing for the first time that the D genome could be particularly important for wheat–bacteria interactions.
Hand hygiene monitoring: Comparison between app and paper forms for direct observation
Authors: Libero Giulia , Bordino Valerio , Garlasco Jacopo , Vicentini Costanza , Maria Zotti Carla 
Published: December 2022

AbstractHealthcare‐associated infections (HAIs) are a global public health threat. Italy is one of the countries with the highest prevalence of HAI. Hand hygiene (HH) is a pillar of infection prevention and control. Monitoring HH is necessary to improve HH compliance, and direct observation is considered the gold standard. Transcription and analysis of data collected during direct observation of HH compliance with the WHO paper form are time‐consuming. We collected, during a 9‐day observation period, HH opportunities and compliance both with a smartphone application (SpeedyAudit) and with the WHO paper form. Then, we investigated the difference in the required time for data transcription and analysis between the WHO paper form and the use of the app. The difference in the required time for data transcription and analysis was significant with a mean time of 2 s using the app and about 14–54 min/day using paper form (p = .004) while no significant difference was found in measured compliance rates between the two data collecting methods. HH monitoring with an app is time‐saving, and the app we used was easy to use.
Performance and physiological quality of Escallonia resinosa seeds: prospects for their use in reforestation and restoration
Authors: Huayta‐Hinojosa L. David , Nolasco‐Lozano Emily , Guerra Damaris , Hermoza‐Gamboa Joel , Quispe‐Melgar Harold Rusbelth 
Published: December 2022

In the Andes, many native forest species are not used in reforestation or restoration programs mainly due to a lack of information about their propagation. In this study, we evaluated the performance of the seeds of Escallonia resinosa by analyzing fruit and seed productivity and characteristics, seed physiological quality, and the germination rate of seeds collected at different stages of fruit physiological maturity, using tetrazolium and standard germination tests. Our results show an estimated production (mean ± SD) of 34,252.5 ± 25,900 fruits per tree and 26.5 ± 20 million seeds per tree. Seed length was 1.0 ± 0.13 mm and seed weight was 12.4 ± 1 μg. We recognized two different morphological types of seeds: Type I seeds (lacking testa) were unviable, whereas all Type II seeds (with testa) germinated. Seed viability and germination rates were 10.5 and 48.6%, respectively; therefore, the viability test underestimated the actual germination rate. Morphological or microsite variables of the parent tree did not influence seed viability or germination. Germination rates were highest (41.8 ± 2.5%) for the seeds of fruits harvested at the initial maturity stage (green fruits). Our results show that E. resinosa is a species with potential for reforestation and restoration projects in the Andes: it has high seed production and good germination performance, and seeds can be harvested from fruits collected at different stages of physiological maturity.
American Jewish humor
Authors: Caplan Jennifer 
Published: December 2022

AbstractThis article charts the development of the particular genre generally known as “Jewish humor.” It provides and overview of the topic for those interested in the relationship between American Jews and humor and the phenomenon of Jewish humor. It aligns the history of the genre with the history of Jews in America to demonstrate the ways in which changes in Jewish American social status was reflected in the type of humor being produced, as well as the way that the evolution of popular media platforms were often shaped and dominated by Jewish content producers. It begins with Yiddish film and theatre and continues through radio and early television, stand‐up comedy, the late twentieth century boom in Jewish sitcoms, the rise of “Generation Hanukkah Song,” and finally the current move toward Internet and social media humor.
Grammaticalization from Minimizer to Focus Marker as Upward Reanalysis along the Nominal Spine*
Authors: Ogawa Yoshiki 
Published: December 2022

AbstractThis article demonstrates that Japanese minimizers, which are originally used as Negative Polarity Items in a negative context, can sometimes behave as focus markers when used postnominally. I will review a previous syntactic analysis of English minimizers, and propose a revised syntactic analysis of Japanese minimizers, based on newly discovered synchronic and diachronic facts. I argue that the usage of Japanese minimizers as focus markers was developed through grammaticalization as Upward Reanalysis along the nominal spine.
Duration of antibiotic treatment for acute graft pyelonephritis: What's the standard of care?
Authors: Kumar Rebecca , Pereira Marcus , Taimur Sarah , True Karin , Detwiler Randall , van Duin David 
Published: December 2022

AbstractBackgroundLimited evidence is available to inform the duration of antibiotic treatment in kidney transplant recipients with bacterial acute graft pyelonephritis. Guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation suggest a 14–21 day duration.MethodsA four‐question survey was constructed to determine the current standard of practice for the duration of treatment for acute graft pyelonephritis. The survey was distributed among members of the Infectious Diseases and the Kidney Pancreas Communities of Practice of the American Society of Transplantation.ResultsAmong 144 survey respondents, 87 (60%) were infectious disease physicians, and 36 (25%) were transplant nephrologists. Although most (55%) respondents preferred a 14‐day duration, a spread between 7 and 28 days was observed. Goals of treatment and drivers for longer duration differed between infectious disease physicians and transplant nephrologists.ConclusionsAlthough most respondents prefer a 14‐day duration of treatment for acute graft pyelonephritis, a wide range of responses was seen between 7 and 28 days. More evidence is needed to inform optimal treatment duration in this common infectious complication after transplantation.
image
Dissecting the functions of COP1 in the UVR8 pathway with a COP1 variant in Arabidopsis
Authors: Zhang Qianwen , Lin Li , Fang Fang , Cui Beimi , Zhu Cheng , Luo Shukun , Yin Ruohe 
Published: December 2022

SUMMARYCOP1 is a critical repressor of plant photomorphogenesis in darkness. However, COP1 plays distinct roles in the photoreceptor UVR8 pathway in Arabidopsis thaliana. COP1 interacts with ultraviolet B (UV‐B)‐activated UVR8 monomers and promotes their retention and accumulation in the nucleus. Moreover, COP1 has a function in UV‐B signaling, which involves the binding of its WD40 domain to UVR8 and HY5 via conserved Val‐Pro (VP) motifs of these proteins. UV‐B‐activated UVR8 interacts with COP1 via both the core domain and the VP motif, leading to the displacement of HY5 from COP1 and HY5 stabilization. However, it remains unclear whether the function of COP1 in UV‐B signaling is solely dependent on its VP motif binding capacity and whether UV‐B regulates the subcellular localization of COP1. Based on published structures of the COP1 WD40 domain, we generated a COP1 variant with a single amino acid substitution, COP1C509S, which cannot bind to VP motifs but retains the ability to interact with the UVR8 core domain. UV‐B only marginally increased nuclear YFP‐COP1 levels and significantly promoted YFP‐COP1 accumulation in the cytosol, but did not exert the same effects on YFP‐COP1C509S. Thus, the full UVR8–COP1 interaction is important for COP1 accumulation in the cytosol. Notably, UV‐B signaling including activation of HY5 transcription was obviously inhibited in the Arabidopsis lines expressing YFP‐COP1C509S, which cannot bind VP motifs. We conclude that the full binding of UVR8 to COP1 leads to the predominant accumulation of COP1 in the cytosol and that COP1 has an additional function in UV‐B signaling besides VP binding‐mediated protein destabilization.
Does Caffeine Increase Fat Metabolism? A Systematic Review and Meta-Analysis
Authors: Conger Scott A. , Tuthill Lara M. , Millard-Stafford Mindy L. 
Published: December 2022

Whether caffeine (CAF) increases fat metabolism remains debatable. Using systematic review coupled with meta-analysis, our aim was to determine effects of CAF on fat metabolism and the relevant factors moderating this effect. Electronic databases PubMed, SPORTDiscus, and Web of Science were searched using the following string: CAF AND (fat OR lipid) AND (metabolism OR oxidation). A meta-analytic approach aggregated data from 94 studies examining CAF’s effect on fat metabolism assessed by different biomarkers. The overall effect size (ES) was 0.39 (95% confidence interval [CI] [0.30, 0.47], p < .001), indicating a small effect of CAF to increase fat metabolism; however, ES was significantly higher (p < .001) based on blood biomarkers (e.g., free fatty acids, glycerol) (ES = 0.55, 95% CI [0.43, 0.67]) versus expired gas analysis (respiratory exchange ratio, calculated fat oxidation) (ES = 0.26, 95% CI [0.16, 0.37]), although both were greater than zero. Fat metabolism increased to a greater extent (p = .02) during rest (ES = 0.51, 95% CI [0.41, 0.62]) versus exercise (ES = 0.35, 95% CI [0.26, 0.44]) across all studies, although ES was not different for studies reporting both conditions (ES = 0.49 and 0.44, respectively). There were no subgroup differences based on participants’ fitness level, sex, or CAF dosage. CAF ingestion increases fat metabolism but is more consistent with blood biomarkers versus whole-body gas exchange measures. CAF has a small effect during rest across all studies, although similar to exercise when compared within the same study. CAF dosage did not moderate this effect.
The Effect of Attentional Focus on Real-Time Conscious Motor Processing During Tandem Walking in Young Adults
Authors: Shahzada Shamoon S. , Mak Toby C.T. , Wong Thomson W.L. 
Published: December 2022

The theory of reinvestment in experimental psychology suggested that automated performance could be degraded if attention was internally diverted to the process of skill execution. This study examined the role of attentional focus instructions on real-time conscious motor processing (i.e., reinvestment) during tandem walking. Thirty-six young adults (mean age = 20.94, SD = 1.43 years) participated; their electroencephalography T3–Fz coherence (i.e., real-time reinvestment) was measured during three walking conditions with different attentional focus instructions: external focus, internal focus, and control conditions. The results suggested that attentional focus instructions did not significantly affect real-time conscious motor processing during tandem walking in young adults, possibly due to the low level of motor task complexity of walking by young adults. The Movement-Specific Reinvestment Scale appears to be not sensitive enough to reflect the real-time reinvestment during gait-related movements in young adults.
Highly Active Bimetallic Single-Atom Alloy PdAg Catalysts on Cerium-Containing Supports in the Hydrogenation of Alkynes to Alkenes
Authors: Rassolov A. V. , Bragina G. O. , Baeva G. N. , Mashkovsky I. S. , Smirnova N. S. , Gerasimov E. Yu. , Bukhtiyarov A. V. , Zubavichus Ya. V. , Stakheev A. Yu. 
Published: December 2022

Abstract
A study of a series of single-atom-alloy catalysts Pd1Ag3/Al2O3, Pd1Ag3/CeO2–Al2O3, and Pd1Ag3/CeO2–ZrO2 in the selective hydrogenation of diphenylacetylene (DPA) showed a significant (five-fold) increase in activity for the PdAg3/CeO2–ZrO2 sample in comparison with that of Pd1Ag3/Al2O3. It was especially noted that the increase in activity was not accompanied by a decrease in the selectivity for the target product. This catalytic behavior can be explained by two factors: (1) a more than twofold increase in the dispersity of the PdAg3/CeO2–ZrO2 catalyst and (2) a change in the electronic state of the nanoparticles, as determined from the results of an IR-spectroscopic study of adsorbed CO. The retention of the high selectivity of the synthesized catalysts indicated the stability of the structure of Pd1 monoatomic sites in the catalysts prepared by deposition on Ce-containing supports, which was also confirmed by the IR spectroscopy of adsorbed CO. The experimental results indicate that Ce-containing supports are promising for the synthesis of catalysts for the selective hydrogenation of substituted alkynes.
Background rejection using image residuals from large telescopes in imaging atmospheric Cherenkov telescope arrays
Authors: Olivera-Nieto L. , Ren H. X. , Mitchell A. M. W. , Marandon V. , Hinton J. A. 
Published: December 2022

AbstractIdentification of Cherenkov light generated by muons has been suggested as a promising way to dramatically improve the background rejection power of Imaging Atmospheric Cherenkov Telescope (IACT) arrays at high energies. However, muon identification remains a challenging task, for which efficient algorithms are still being developed. We present an approach in which, rather than identifying Cherenkov light from muons, we simply consider the presence of Cherenkov light other than the main shower image in IACTs with large mirror area. We show that in the case of the H.E.S.S. array of five telescopes this approach results in background rejection improvements at all energies above 1 TeV. In particular, the rejection power can be improved by a factor $$\sim \,3$$

∼

3

–4 at energies above 20 TeV while keeping $$\sim \,90\%$$

∼

90
%

of the original gamma-ray efficiency.
New jig adapted for compression fatigue tests on composite materials
Authors: Gonçalves Vanderlei de Oliveira , Osses Marcelo , Pardini Luiz Claudio 
Published: December 2022

This paper presents a new adapted jig to perform quasi-static and fatigue compression tests based on the Combined Loading Compression (CLC), ASTM D6641 standard. This new jig is proposed to enable the performance of both static and fatigue tests accommodating various types of composite materials, different test standards, and coupons sizes. In order to validate the new testing jig, quasi-static and fatigue tests were performed in a composite with bidirectional carbon-fiber fabric type 8HS (Hardness Satin) with epoxy resin matrix. The numer 8 on 8HS means that during the production process, the warp yarn goes over seven before going under one fill yarn. The static and fatigue compressive stresses obtained for the 8HS composite were 643.2 MPa and 436.6 MPa respectively.
The Naturalness Bias Influences Drug and Vaccine Decisions across Cultures
Authors: Ji Li-Jun , Lappas Courtney M. , Wang Xin-qiang , Meier Brian P. 
Published: December 2022

Past research with North American participants has demonstrated a naturalness bias in the medical context: people prefer natural drugs to synthetic drugs under a variety of situations. Does such a bias exist in other countries (such as China) where cultural values and practices are quite different from those in the United States? We conducted 3 studies ( N = 1,927) to investigate the naturalness bias with drugs and vaccines across cultures with American, Canadian, and Chinese participants. In studies 1A and 1B, participants chose or rated drugs (natural v. synthetic) for a hypothetical medical issue. The drugs were presented as having identical effectiveness and side effect profiles. Study 2 focused on a different medical context, vaccines, and required participants to rate their likelihood of taking vaccines (made from either more natural or more synthetic ingredients) for a harmful virus. The naturalness bias occurred across cultures in studies 1A and 1B, although it was not significant among Chinese participants in study 1B. In study 2, Chinese participants showed a stronger naturalness bias than Americans did, and safety concerns mediated the effect. Perceived safety accounted for the naturalness bias among Americans and Canadians, but did so only among Chinese in study 2. Overall, the results suggest that the naturalness bias in drug and vaccine decision making occurs across cultures, but Chinese participants may be more sensitive to the medical context. Highlights The naturalness bias — preferring natural to synthetic drugs or vaccines — occurred across cultures (Americans, Canadians, and Chinese). Chinese participants showed a stronger naturalness bias than Americans did when the medical context was focused on vaccination, and safety concerns mediated this effect. The naturalness bias may influence medical decision making across cultures, but Chinese participants may be more sensitive to naturalness in a vaccine context.
CCL22 and CCL26 are potential biomarkers for predicting distant metastasis in thyroid carcinoma
Authors: Tong Junyu , Jiang Wen , Zhang Xiaoying , Wang Ru , Qiao Tingting , Song Yingchun , Gao Dingwei , Yu Xiaqing , Lv Zhongwei , Li Dan 
Published: December 2022

Objectives Chemokines have been suggested to play significant roles in the progression of malignant cancers. This study aimed to identify the chemokines related to malignant progression in thyroid carcinoma. Methods The mRNA expression levels of 52 chemokines were compared between differentiated thyroid cancer (DTC) samples and normal thyroid tissues from The Cancer Genome Atlas database; survival analysis was then performed on the basis of differentially expressed chemokines. A retrospective study was conducted on the level of differentially expressed chemokines in 76 DTC patients. Functional pathway analysis was performed to explore chemokine-related regulatory mechanisms. Results We identified 20 chemokines with differentially expressed mRNA levels through publicly available data. High levels of CCL22 and CCL26 were found to be related with metastasis in clinical DTC samples. High levels of CCL22 were found to be significantly related to poor prognosis in DTC patients. Pathway analyses revealed that cytokines might affect cancer progression through cytokine-cytokine receptor and cytokine-interleukin interactions. Conclusions CCL22 and CCL26 could serve as prognostic biomarkers in thyroid carcinoma.
CCK regulates osteogenic differentiation through TNFα/NF-κB in peri-implantitis
Authors: Chou LongHang , Chang YaTing , Lan KaiWen , Liu Meng , Lu YuKun , Li XiaoLei , Li PeiRu , Xu Yue 
Published: December 2022

Objective Peri-implantitis is characterized by peri-implant mucositis and alveolar bone resorption. This study investigated cholecystokinin ( CCK) expression and the mechanism underlying its involvement in peri-implantitis. Methods mRNA sequencing was performed using the Gene Expression Omnibus database GSE106090. Human bone marrow mesenchymal stem cells (hBMSCs) were pretreated with various concentrations of CCK (0, 10, 30, or 100 nM) for 1 hour before induction in osteogenic differentiation medium for 2 weeks. Alkaline phosphatase (ALP) activity was determined, and the cells were stained with alizarin red. The expression levels of TNFα and the osteogenic markers ALP, RUNX2, and OCN were measured using quantitative real-time PCR. TNFα, phosphorylated P65, and total P65 levels were determined by western blot. Results Compared with healthy individuals, 262 and 215 genes were up- and down-regulated, respectively, in the periodontal tissues of patients with peri-implantitis. CCK expression was significantly upregulated in patients with peri-implantitis. CCK reduced ALP activity, osteogenic differentiation, and levels of the osteogenic markers ALP, RUNX2, and OCN. Moreover, CCK promoted levels of TNFα and phosphorylated P65, which is a marker of activation for the NF-κB inflammatory pathway. Conclusions CCK regulates osteogenic differentiation through the TNFα/NF-κB axis in peri-implantitis.
CoronaVac, BNT162b2 and heterologous COVID-19 vaccine outcomes in patients with ventricular assist device
Authors: Karahan Mehmet , Kervan Umit , Kocabeyoglu Sinan Sabit , Sert Dogan Emre , Tekce Yasemin Tezer , Yavuz Omer Abdullah , Kucuker Seref Alp , Ozatik Mehmet Ali , Catav Zeki , Sener Erol 
Published: December 2022

Background: A consensus has not yet been reached regarding which COVID-19 vaccine program should be applied in patients with ventricular assist device (VAD). Our aim was to assess the clinical outcome of inactivated, mRNA and heterologous vaccine program in patient with VAD. Methods: In this retrospective and cross-sectional study; adult patients who underwent VAD implantation between January 2012 and September 2021 and received any vaccine that were used in Republic of Türkiye for COVID-19, were included. The patients were divided into three groups according to the type of vaccine; “inactivated,” “mRNA” and “heterologous.” Clinical outcomes were analyzed. Results: Eighteen patients were in each group in the “inactivated,” “mRNA” and “heterologous” groups. Mean age was 51.6 ± 12 years in “inactivated” group, 42.5 ± 15.5 years in “mRNA” group and 41.1 ± 15.4 years in “heterologous” group. There was no significant difference between the groups in age, gender, body surface area, body mass index and etiology ( p > 0.05). After last dose of vaccines, the number of patients had COVID-19 positive test were three (16.7%), one (5.6%), and two (11.1%) in “inactivated,” “mRNA” and “heterologous” groups, respectively. Pump thrombosis was seen in two patients in “mRNA” group and one patient in “heterologous” group. No pump thrombosis was seen in “inactivated” group. COVID-19-related death or intubation was not observed. Conclusion: All vaccine that used for COVID-19 are safe and effective in patients with VAD. In countries that give priority to inactivated vaccines, mRNA vaccines may then be made as boosters.