bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD19/CD20 Bispecific Chimeric Antigen Receptor (CAR) in Naive/Memory T Cells for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma
Authors: Larson Sarah M. , Walthers Christopher M. , Ji Brenda , Ghafouri Sanaz N. , Naparstek Jacob , Trent Jacqueline , Chen Jia Ming , Roshandell Mobina , Harris Caitlin , Khericha Mobina , Schweppe Thomas , Berent-Maoz Beata , Gosliner Stanley B. , Almaktari Amr , Ceja Melanie Ayala , Allen-Auerbach Martin S. , Said Jonathan , Nawaly Karla , Mead Monica , de Vos Sven , Young Patricia A. , Oliai Caspian , Schiller Gary J. , Timmerman John M. , Ribas Antoni , Chen Yvonne Y. 
Published: November 2022

AbstractTo address antigen escape and loss of T-cell functionality, we report a phase I clinical trial (NCT04007029) evaluating autologous naive and memory T (TN/MEM) cells engineered to express a bispecific anti-CD19/CD20 chimeric antigen receptor (CAR; CART19/20) for patients with relapsed/refractory non-Hodgkin lymphoma (NHL), with safety as the primary endpoint. Ten patients were treated with 36 × 106 to 165 × 106 CART19/20 cells. No patient experienced neurotoxicity of any grade or over grade 1 cytokine release syndrome. One case of dose-limiting toxicity (persistent cytopenia) was observed. Nine of 10 patients achieved objective response [90% overall response rate (ORR)], with seven achieving complete remission [70% complete responses (CR) rate]. One patient relapsed after 18 months in CR but returned to CR after receiving a second dose of CART19/20 cells. Median progression-free survival was 18 months and median overall survival was not reached with a 17-month median follow-up. In conclusion, CART19/20 TN/MEM cells are safe and effective in patients with relapsed/refractory NHL, with durable responses achieved at low dosage levels.Significance:Autologous CD19/CD20 bispecific CAR-T cell therapy generated from TN/MEM cells for patients with NHL is safe (no neurotoxicity, maximum grade 1 cytokine release syndrome) and demonstrates strong efficacy (90% ORR, 70% CR rate) in a first-in-human, phase I dose-escalation trial.This article is highlighted in the In This Issue feature, p. 517
Measuring Under- and Overreaction in Expectation Formation
Authors: Kučinskas Simas , Peters Florian S. 
Published: November 2022

Abstract
We develop a framework for measuring under- and overreaction in expectation formation. The basic insight is that under- and overreaction to new information is identified (up to sign) by the impulse response function of forecast errors. Our measurement procedure yields estimates of under- and overreaction to different shocks at various horizons. In an application to inflation expectations, we find that forecasters underreact to aggregate shocks but overreact to idiosyncratic shocks. We illustrate how our approach can be used to (i) quantify the importance of different biases, (ii) estimate theoretical models, and (iii) shed light on existing empirical approaches and puzzles.
A Canonical Representation of Block Matrices with Applications to Covariance and Correlation Matrices
Authors: Archakov Ilya , Hansen Peter Reinhard 
Published: November 2022

Abstract
We obtain a canonical representation for block matrices. The representation facilitates simple computation of the determinant, the matrix inverse, and other powers of a block matrix, as well as the matrix logarithm and the matrix exponential. These results are particularly useful for block covariance and block correlation matrices, where evaluation of the Gaussian log-likelihood and estimation are greatly simplified. We illustrate this with an empirical application using a large panel of daily asset returns. Moreover, the representation paves new ways to model and regularize large covariance/correlation matrices, test block structures in matrices, and estimate regressions with many variables.
Intra-household Frictions, Anchoring, and the Credit Card Debt Puzzle
Authors: Vihriälä Erkki 
Published: November 2022

Abstract
I study how intra-household frictions and anchoring contribute to the credit card debt puzzle, the co-holding of high-cost debt, and low-yield liquid assets. First, I find couples co-hold 42% more as units than as individuals relative to income. Moreover, in a natural experiment, couples do not cooperate to reduce high-cost debt, suggesting that intra-household frictions contribute to co-holding. Second, I find individuals who regularly make credit card debt payments equal to or near the minimum account for 59% of individual co-holding. The evidence suggests anchoring to the minimum payment contributes to co-holding via these low payments.
Job Market Signaling through Occupational Licensing
Authors: Blair Peter Q. , Chung Bobby W. 
Published: November 2022

Abstract
Among men, the Black-white wage gap is as large today as it was in 1950. We test whether this gap is due to asymmetric information using newly collected data on occupational licensing laws that ban workers with criminal records. We find evidence supporting this hypothesis. The licensing premiums for Black men are largest in licensed occupations that restrict felons, particularly in states with banthe-box laws and at small businesses. In these contexts where a worker’s criminal history is difficult to infer, we find that occupational licensing reduces asymmetric information and reduces the racial wage gap.
The Impact of Return Migration on Economic Development
Authors: Bucheli José R. , Fontenla Matías 
Published: November 2022

Abstract
Mexican migration to the United States—one of the largest flows in human history—inverted in the late 2000s, and during the next decade more Mexicans returned home than those who migrated north. We exploit this historical reversal to estimate the effects of return migration on economic development in Mexico. We find that return migration leads to higher levels of development through improved income, labor, health, and educational outcomes. Our findings suggest that the benefits of migration extend beyond individuals’ tenure abroad, as accumulated capital, skills, and social norms have the potential to contribute to development back home.
The נזם and Navigating Power Structures
Authors: Rees Susannah 
Published: November 2022

Abstract
Important facets of identity can be communicated through dress. Descriptions of dress and body adornment within the text of the Hebrew Bible can therefore be used as a narrative device to convey subtextual information about the wearer. By utilising archaeological research on the role that jewellery plays in age and gender differentiation alongside textual evidence, this article argues that נזם rings are worn by women and children of both genders to convey messages about their valuation, commodification and ownership in relation to a male patriarch. This has important implications for understanding the nuances within the biblical texts themselves and offers new perspectives and interpretative possibilities.
“It is Permitted for the Amīr but not the Qāḍī”: The Military-Administrative Genealogy of Coercion in Abbasid Criminal Justice
Authors: Allehbi Mohammed 
Published: November 2022

Abstract
Muslim rulers and law enforcers used coercion as an evidentiary method for criminal cases during the Abbasid period. These coercive procedures consisted of imprisonment, threats of beatings, and lashings. Coercive interrogations were shaped by the practices of the shurṭa (criminal magistrates and police chiefs), based on military methods, administrative precedents, and discretion, not on fiqh (Islamic substantive law). In the Abbasid era (300–500 A.H./900–1100 C.E.), government officials, such as Ibn Wahb (d. after 335/946), and even some jurists, particularly the chief judge al-Māwardī (d. 450/1058), legitimized these coercive practices by framing their use as a matter determined by authority and jurisdiction. By tracing the military-administrative genealogy of coercion, I seek to examine the methods and reasoning that constituted the criminal justice system that came to be known as siyāsa. Drawing on various administrative and literary sources, I examine a history of coercion in Islamic law beyond fiqh.
The Preslavery Praxis and Ethos of the Religion of West African People
Authors: Lamak Kefas 
Published: November 2022

Abstract
Compared to other world religions such as Christianity, Islam, Judaism, Hinduism, and Buddhism, West African Traditional Religion (WATR) has been misunderstood, misinterpreted, and misrepresented in Euro-American society since the colonial encounter of Africans and Europeans. Sadly, the colonial naming and categorizing of West African religion as savage, animism, and idol worship continues in the popular culture of Euro-America. This paper aims to demonstrate with clear examples how West African Traditional Religion of the 1400s is similar to any other world religion. West African Traditional Religion is better understood alongside African culture and history than as an independent subject. Disagreeing with European missionaries’ claim that they were the ones who taught West Africans about the supreme God, this paper explains how West Africans in precolonial periods had constructive knowledge of supreme deities and other beliefs.
Factors Motivating Chinese Malaysian University Students’ Educational Mobility to Taiwan
Authors: Yu Ting-Fai 
Published: November 2022

Abstract
Based on a project on Chinese Malaysians’ educational mobility across the Chinese-speaking world, this paper highlights their reasons for attending university in Taiwan while examining their subjective formations as ethnic Chinese vis-à-vis transnational processes. Resulting from ethnographic and interview-based research conducted in 2019–2021, the findings demonstrate that the students’ choices for higher education are, to a great extent, culturally driven and historically contingent. Thus they provide an alternative view to the dominant paradigm of international student mobility that emphasises economic and future career incentives. By focusing on three factors—state racism, historical connections, and Sinophone cultural consumption—that motivated them to leave Malaysia and go to Taiwan, this paper moreover draws attention to the transnational infrastructures (e.g. policy, media, interpersonal networks) that have continually reproduced and transformed a long-existing migration pattern.
The Current Landscape of Taiwan Studies Using ijts Keywords
Authors: Yen Wei-Ting , Tang Shu-wen 
Published: November 2022

Abstract
This report collects all the keywords that have appeared in the International Journal of Taiwan Studies since its first issue in February 2018. The authors use these keywords and resulting word clouds to reflect on the current state of Taiwan-related research. We find that publications are still heavily dominated by cross-Strait-related topics and that, despite the aspiration of putting Taiwan in a comparative perspective, the results have so far been relatively limited. We suggest including more topical sections in future issues as one way to diversify the interdisciplinary and comparative scope of the journal.
“This is The Very Place!”: Shi Daoxuan 釋道宣 (c. 596–667) and The Creation of Buddhist Sacred Sites in China
Authors: Nicol Janine 
Published: November 2022

Abstract
Scholars such as John Strong and James Robson have laid firm foundations for the study of the development of Buddhist sacred geography, highlighting the role of relics, stupas and the importance of pre-Buddhist sites of religious significance. Their work has inspired this paper which examines extracts from three texts produced by the monk Shi Daoxuan between 650 and 667 ce: the Shijia fangzhi 釋迦方志 (A Geography of the Śākyas, 650 ce), the Ji Shenzhou Sanbao gantong lu 集神州三寶感通錄 (Collected Records of Stimulus and Responses to the Triple Gem in the Divine Continent, 664) and the Lüxiang gantong zhuan 律相感通傳 (Account of the Stimuli and Responses Related to the Vinaya, 667). Concentrating on two places, the Zhongnan Mountains and Mount Wutai, these materials provide a rare opportunity to examine the role one man played in the promotion of these sites over few decades. This paper argues that Daoxuan was among the first to promote the idea of Mañjuśrī being present in China, initially in the Zhongnan, and only latterly on Wutai, and that Daoxuan was influenced by the picture of Indian Buddhist sacred geography provided by the accounts of Xuanzang’s travels in his consolidation and development of a similar geography for China. Daoxuan utilised Buddhist and non-Buddhist writings, and eyewitness testimony from the human realm and beyond, in his efforts to promote these two places. A close reading of these extracts can provide insight into the factors which stimulate the creation of sacred sites, and the methods and processes through which they develop and evolve.
Regular cannabis use modulates the impact of HIV on the neural dynamics serving cognitive control
Authors: Schantell Mikki , Springer Seth D , Arif Yasra , Sandal Megan E , Willett Madelyn P , Johnson Hallie J , Okelberry Hannah J , O’Neill Jennifer L , May Pamela E , Bares Sara H , Wilson Tony W 
Published: November 2022

Background: Cannabis use and HIV are independently associated with decrements in cognitive control. However, the combined effects of HIV and regular cannabis use on the brain circuitry serving higher-order cognition are unclear. Aims: Investigate the interaction between cannabis and HIV on neural interference effects during the flanker task and spontaneous activity in regions underlying higher-order cognition. Methods: The sample consisted of 100 participants, including people with HIV (PWH) who use cannabis, PWH who do not use cannabis, uninfected cannabis users, and uninfected nonusers. Participants underwent an interview regarding their substance use history and completed the Eriksen flanker task during magnetoencephalography (MEG). MEG data were imaged in the time–frequency domain and oscillatory maps depicting the neural flanker interference effect were probed for group differences. Voxel time series were then assessed for group-level differences in spontaneous activity. Results: Group differences in behavioral performance were identified along with group differences in theta and alpha neural interference responses in higher-order regions across the cortex, with nonusers with HIV generally exhibiting the most aberrant responses. Likewise, time series analyses indicated that nonusers with HIV also had significantly elevated spontaneous alpha activity in the left inferior frontal and dorsolateral prefrontal cortices (dlPFC). Finally, we found that spontaneous and oscillatory alpha activity were significantly coupled in the inferior frontal cortex and dlPFC among cannabis users, but not nonusers. Conclusions: Regular cannabis use appears to suppress the impact of HIV on spontaneous and oscillatory alpha deficits in the left inferior frontal cortex and dlPFC.
Personal Antecedents of Entrepreneurial Intention: A Perceptual Study on Generation Z Girls
Authors: Adhikari Kingshuk , Ghosh Ankita 
Published: November 2022

The participation of women in business is ever increasing, and there is a gradual increase of enterprises owned by women in India. Women entrepreneurship development is rising in different states of India, but the growth of women entrepreneurship is relatively low in the northeastern region. Entrepreneurship development is dependent upon entrepreneurial intention, which is again contingent upon personal antecedents. The study makes an attempt to analyse the perception of college-going female students over the personal antecedents influencing entrepreneurial intention. Fifteen components influencing entrepreneurial intention have been identified and grouped under five personal antecedents to prepare questionnaire and conduct online survey. Population includes female students of colleges of Silchar town of Assam, and the sample size is 88. Relevant descriptive and inferential statistics have been used. The most influential personal antecedent triggering entrepreneurial intention is ‘Need for achievement’, which is followed by ‘Self-confidence’, ‘Risk-bearing capacity’, ‘Creativity’ and ‘Adaptability’. JEL Code: M13, D9, L26, L31, I23
Distal femoral extension osteotomy and patellar tendon advancement or shortening in ambulatory children with cerebral palsy: A modified Delphi consensus study and literature review
Authors: Rutz Erich , Novacheck Tom F , Dreher Thomas , Davids Jon R , McCarthy James , Kay Robert M , Shore Benjamin J , Shrader M Wade , Veerkamp Matthew , Chambers Hank , Narayanan Unni , Pierz Kristan , Rhodes Jason , Shilt Jeffrey , Theologis Tim , Van Campenhout Anja , Graham Kerr 
Published: November 2022

Purpose: In children with cerebral palsy, flexion deformities of the knee can be treated with a distal femoral extension osteotomy combined with either patellar tendon advancement or patellar tendon shortening. The purpose of this study was to establish a consensus through expert orthopedic opinion, using a modified Delphi process to describe the surgical indications for distal femoral extension osteotomy and patellar tendon advancement/patellar tendon shortening. A literature review was also conducted to summarize the recent literature on distal femoral extension osteotomy and patellar tendon shortening/patellar tendon advancement. Method: A group of 16 pediatric orthopedic surgeons, with more than 10 years of experience in the surgical management of children with cerebral palsy, was established. The group used a 5-level Likert-type scale to record agreement or disagreement with statements regarding distal femoral extension osteotomy and patellar tendon advancement/patellar tendon shortening. Consensus for the surgical indications for distal femoral extension osteotomy and patellar tendon advancement/patellar tendon shortening was achieved through a modified Delphi process. The literature review, summarized studies of clinical outcomes of distal femoral extension osteotomy/patellar tendon shortening/patellar tendon advancement, published between 2008 and 2022. Results: There was a high level of agreement with consensus for 31 out of 44 (70%) statements on distal femoral extension osteotomy. Agreement was lower for patellar tendon advancement/patellar tendon shortening with consensus reached for 8 of 21 (38%) of statements. The literature review included 25 studies which revealed variation in operative technique for distal femoral extension osteotomy, patellar tendon advancement, and patellar tendon shortening. Distal femoral extension osteotomy and patellar tendon advancement/patellar tendon shortening were generally effective in correcting knee flexion deformities and extensor lag, but there was marked variation in outcomes and complication rates. Conclusion: The results from this study will provide guidelines for surgeons who care for children with cerebral palsy and point to unresolved questions for further research. Level of evidence: level V.
Adjusting Therapy Profiles When Switching to Ultra-Rapid Lispro in an Advanced Hybrid Closed-Loop System: An in Silico Study
Authors: Colmegna Patricio , Diaz C. Jenny L. , Garcia-Tirado Jose , DeBoer Mark D. , Breton Marc D. 
Published: November 2022

Background: It has been shown that insulin acceleration by itself might not be sufficient to see clear improvements in glycemic metrics, and insulin therapy may need to be adjusted to fully leverage the extra safety margin provided by faster pharmacokinetic (PK) and pharmacodynamic (PD) profiles. The objective of this work is to explore how to perform such adjustments on a commercially available automated insulin delivery (AID) system. Methods: Ultra-rapid lispro (URLi) is modeled within the UVA/Padova simulation platform using data from previously published clamp studies. The Control-IQ AID algorithm is selected as it leverages carbohydrate-to-insulin ratio (CR in g/U), correction factor (CF in mg/dL/U), and basal rate (BR in U/h) daily profiles that are fully customizable. An experiment roadmap is proposed to understand how to safely modify these profiles when switching from lispro to URLi. Results: Simulations show that a 7% decrease in CR (approximately an 8% increase in prandial insulin) and a 7.5% increase in BR lead to cumulative improvements in glucose control with URLi. Comparing with baseline metrics using lispro, a clinically significant increase in time in the range of 70 to 180 mg/dL (overall: 70.2%-75.2%, P < .001; 6 am-12 am: 62.4%-68.5%, P < .001) and a reduction in time below 70 mg/dL (overall: 1.8%-1.2%, P < .001; 6 am-12 am: 1.8%-1.3%, P < .001) were observed. Conclusion: Properly adjusting therapy parameters allows to fully leverage glucose control benefits provided by faster insulin analogues, opening opportunities to take another step forward into a next generation of more effective AID solutions.
HRQoL and nutritional well-being dissimilarities between two different online collection methods: Value for digital health implementation
Authors: Higuera-Gomez Andrea , Ribot-Rodriguez Rosa , San-Cristobal Rodrigo , Martín-Hernández Roberto , Mico Victor , Espinosa-Salinas Isabel , Ramirez de Molina Ana , Martinez J Alfredo 
Published: November 2022

Background Online health data collection has gained a reputation over the last years to record and process information about health issues for implementing digital health. Objective The research aim was to appraise two online methods (open and rewarded) to collect information about HRQoL and nutritional well-being and to compare the results between both surveyed populations. Methods This cross-sectional study is framed on the NUTRiMDEA project. Online data through two different web-based methods (open survey and rewarded survey) were retrieved to assemble data related to sociodemographic, lifestyle (diet, physical activity and sleep patterns) and general health aspects, as well as HRQoL by an evidence-based form such as the SF-12 questionnaire, the IPAQ survey, and MEDAS-14, participants were adults (>18 years old). Results Overall, 17,332 participants responded to the open survey (OS, n = 11,883) or the rewarded survey (RS, n = 5449). About 65.1% of the participants were female, while the mean age was in the range of 40–70 years. There were significant differences ( p < 0.05) between surveyed populations in sociodemographic, lifestyle (diet and physical activity), health and HRQoL data. Conclusions This investigation implemented an evidence-based online questionnaire that collected demographic, lifestyle factors, phenotypic and health-related aspects as well as compared differential outcomes in HRQoL and nutritional/lifestyle well-being depending on the online mode data collection. Findings demonstrated dissimilarities in most aspects of health, HRQoL, dietary intake and physical activity records between both populations. Overall, OS sample was characterized as a healthier population with superior lifestyle habits than RS participants.