bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hubungan Kecemasan dengan Prokrastinasi Akademik Mahasiswa Prodi Pendidikan Masyarakat dalam Melaksanakan PLP FKIP UNRI
Authors: Roidah Siti , Wilson Wilson , Achmad Said Suhil 
Published: March 2022

PLP atau Pengenalan Lapangan Persekolahan merupakan mata kuliah wajib dengan beban tugas dan SKS yang banyak, sehingga dalam pelaksanaannya, mahasiswa seringkali kebingunan untuk menentukan mana yang harus diselesaikan terlebih dahulu. Mahasiswa juga sering kesulitan dalam menyelesaikan semua tugas dari dosen pembimbing atau lembaga tempat mahasiswa melaksanakan PLP tepat waktu. Studi ini bertujuan menyelidiki hubungan antara kecemasan dan prokrastinasi akademik. Untuk mencapai tujuan tersebut, peneliti menggunakan metode penelitian kuantitatif dan strategi deskriptif. Hipotesis diuji dengan memanfaatkan teknik analisa linear berganada. Hasil pengujian terhadap hipotesis menunjukkan bahwa kecemasan memiliki hubungan yang signifikan dengan munculnya prokrastinasi akademik pada mahasiswa.

The PLP is a mandatory field recognition activity with a high degree of duty and SKS load for a student body so that in the process it is not uncommon for students to feel confused as to which tasks should be done first, or set time to be on time for chores, whether they are given by the PLP advisor or the institution where students carry out the PLP. The purpose of this study is to find out if the cause of confusion that leads to a delay in this student is caused by the relationship between anxiety and academic procrastination, to which researchers aim to find out how high the anxiety related to the academic program is, Researchers figured that out by using a research ordinance (method) called a quantitative that USES a descriptive strategy. The hypotheses offered have been tested using an alternating linear analysis technique. Based on the results of the testing of the mortgage, it is claimed that the result of anxiety has a significant relationship to the development of the student's academic prejudice.
Analisis Rasionalisasi Nilai-Nilai Mitos Kemponan pada Masyarakat Etnis Melayu
Authors: Purwanto Agus , Imran Imran , Ramadhan Iwan 
Published: March 2022

Penelitian ini bertujuan untuk mengetahui rasionalisasi nilai-nilai mitos kemponan pada masyarakat etnis Melayu di Desa Peniti Besar Kabupaten Mempawah. Penelitian ini menggunakan metode pendekatan kualitatif deskriptif dalam menggambarkan mitos kemponan yang dipercayai masyarakat dan mengobservasi serta mewawancarai masyarakat setempat. Teknik pengumpulan data yaitu observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa mitos kemponan yang mengandung nilai-nilai yang bersifat rasional, tetapi tidak diketahui oleh masyarakat yang hanya percaya bahwa mitos kemponan hanya berisi bala atau malapetaka. Padahal, hal ini bisa dibuktikan dengan terdapatnya jenis-jenis, fungsi, dan makna rasionalisasi nilai-nilai mitos kemponan.

The research aimed at knowing a rationalizing of the mythical virtues of reverberation on Malay communities in the village of big safety pins in the pawning county. The study USES a descriptive qualitative approach to address the myth of the kempean village of the great pin district over, and to observe and interview local communities. The data-collection technique used is observation, interview and documentation. Research has shown that the myth of the death of the Malay people in the village of great pin holds rational but unknown values of a society whose memorandum bene simply believes that the myth of kemponan merely contains a bala or disaster is proven by its potential, a function and meaning of rationalizing the mythic values of kemponan.
Method of Selection of Suppliers of Dietary Supplement Manufacturing Companies
Authors: Szentesi Szabolcs , Tamás Péter , Illés Béla 
Published: March 2022

Literature analyzes show that there are a huge number of supplier selection methods in a wide variety of fields, however, there is little literature on medicine or dietary supplements. Among these publications, there is no developed method that would provide a general solution for the selection of a supplier of all food supplement companies. Some of the methods do not take into account quality parameters (eg. concentration, transport error rate, etc.) and others do not take into account aspects related to environmental protection, the importance of which is becoming more and more important nowadays. In the dissertation, a general decision-making method for the selection of suppliers of food supplement manufacturing companies is presented, which takes into account the logistical and environmental parameters in both qualitative and quantitative terms. The method presented in the dissertation is described through an example.
Menjajaki Relevansi Folklor Desa (Keraton) Domas dengan Toponimi Lima Kampung: Suatu Kajian Historis dan Struktur Tanda
Authors: Wulandari Linda Sari , Rosalina Erlyn 
Published: March 2022

Desa Domas berada di Kecamatan Pontang Kabupaten Serang Provinsi Banten. Desa Domas terdiri atas lima kampung, yaitu Domas, Wanayasa, Sampang Kulon, Pepetan, dan Cerocoh. Akan tetapi, berdasarkan folklor, Desa Domas disebut juga Keraton Domas yang berhubungan dengan kisah Prabu Saka Domas (pemimpin rakyat yang memiliki kesaktian). Namun, berdasarkan sumber lain, Desa Domas berasal dari kata sebelas ekor buaya yang hidup di rawa-rawa. Tujuan dari penelitian ini untuk menelusuri relevansi toponimi Desa Domas yang memiliki folklor sebagai Keraton Domas dengan lima kampung yang ada di dalamnya. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif melalui kajian historis dan struktur tanda. Peneliti melakukan studi literatur, wawancara, serta observasi. Hasil penelitian ini menunjukkan bahwa toponimi dari kelima kampung yang ada di Desa Domas memiliki satu kesamaan yang mengacu pada unsur alamiah, air dan hutan. Toponimi Domas yang diambil dari nama Prabu Saka Domas merupakan bentuk penghargaan rakyat atas kisah heroik Prabu Saka Domas dalam membuat sumur air tawar yang menjadi sumber penghidupan rakyatnya. Apabila dikaji dari hubungan sistem tanda, toponimi Domas tetap mengandung unsur air sehingga masih relevan dengan keempat nama kampung lainya yang mengandung unsur air dan hutan. Berdasarkan situasi geografisnya, wilayah Domas sebagian besar berupa daerah rawa dan hutan mangrove.
Real-World Walking Speed Assessment Using a Mass-Market RTK-GNSS Receiver
Authors: Reggi Luca , Palmerini Luca , Chiari Lorenzo , Mellone Sabato 
Published: March 2022

Walking speed is an important clinical parameter because it sums up the ability to move and predicts adverse outcomes. However, usually measured inside the clinics, it can suffer from poor ecological validity. Wearable devices such as global positioning systems (GPS) can be used to measure real-world walking speed. Still, the accuracy of GPS systems decreases in environments with poor sky visibility. This work tests a solution based on a mass-market, real-time kinematic receiver (RTK), overcoming such limitations. Seven participants walked a predefined path composed of tracts with different sky visibility. The walking speed was calculated by the RTK and compared with a reference value calculated using an odometer and a stopwatch. Despite tracts with totally obstructed visibility, the correlation between the receiver and the reference system was high (0.82 considering all tracts and 0.93 considering high-quality tracts). Similarly, a Bland Altman analysis showed a minimal detectable change of 0.12 m/s in the general case and 0.07 m/s considering only high-quality tracts. This work demonstrates the feasibility and validity of the presented device for the measurement of real-world walking speed, even in tracts with high interference. These findings pave the way for clinical use of the proposed device to measure walking speed in the real world, thus enabling digital remote monitoring of locomotor function. Several populations may benefit from similar devices, including older people at a high risk of fall, people with neurological diseases, and people following a rehabilitation intervention.
Active Metabolites From the Endophyte Paenibacillus polymyxa Y-1 of Dendrobium nobile for the Control of Rice Bacterial Diseases
Authors: Yi Wenshi , Chen Chao , Gan Xiuhai 
Published: March 2022

Microbial bactericides have been a research hotspot in recent years. In order to find new microbial fungicides for preventing and treating rice bacterial diseases, Paenibacillus polymyxa Y-1 (P. polymyxa Y-1) was isolated from Dendrobium nobile in this study, and the optimal medium was selected by a single-factor experiment, and then eight metabolites were isolated from P. polymyxa Y-1 fermentation broth by bioactivity tracking separation. The bioassay results showed that 2,4-di-tert-butylphenol, N-acetyl-5-methoxytryptamine, and P-hydroxybenzoic acid have good antibacterial activity against Xanthomonas oryzae pv. Oryzicola (Xoo) and Xanthomonas oryzae pv. oryzae (Xoc), with 50% effective concentration values of 49.45 μg/ml, 64.22 μg/ml, and 16.32 μg/ml to Xoo, and 34.33 μg/ml, 71.17 μg/ml, and 15.58 μg/ml to Xoc, respectively, compared with zhongshengmycin (0.42 and 0.82 μg/ml, respectively) and bismerthiazol (85.64 and 92.49 μg/ml, respectively). In vivo experiments found that 2,4-di-tert-butylphenol (35.9 and 35.4%, respectively), N-acetyl-5-methoxytryptamine (42.9 and 36.7%, respectively), and P-hydroxybenzoic acid (40.6 and 36.8%, respectively) demonstrated excellent protective and curative activity against rice bacterial leaf blight, which were better than that of zhongshengmycin (38.4 and 34.4%, respectively). In addition, after 2,4-di-tert-butylphenol, N-acetyl-5-methoxytryptamine, and P-hydroxybenzoic acid acted on rice, SOD, POD, and CAD defense enzymes increased under the same condition. In conclusion, these results indicated that the activity and mechanism research of new microbial pesticides were helpful for the prevention and control of rice bacterial diseases.
Diagnosis of Cardiac Amyloidosis Using a Radiomics Approach Applied to Late Gadolinium-Enhanced Cardiac Magnetic Resonance Images: A Retrospective, Multicohort, Diagnostic Study
Authors: Zhou Xi Yang , Tang Chun Xiang , Guo Ying Kun , Tao Xin Wei , Chen Wen Cui , Guo Jin Zhou , Ren Gui Sheng , Li Xiao , Luo Song , Li Jun Hao , Huang Wei Wei , Lu Guang Ming , Zhang Long Jiang , Huang Xiang Hua , Wang Yi Ning , Yang Gui Fen 
Published: March 2022

ObjectivesTo assess the potential of a radiomics approach of late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) in the diagnosis of cardiac amyloidosis (CA).Materials and MethodsThis retrospective study included 200 patients with biopsy-proven light-chain (AL) amyloidosis. CA was diagnosed on the basis of systemic amyloidosis confirmed with evidence of cardiac involvement by imaging and clinical biomarkers. A total of 139 patients [54 ± 8 years, 75 (54%) men] in our institution were divided into training cohort [n = 97, mean age of 53 ± 8 years, 54 (56%) men] and internal validation cohort [n = 42, mean age: 56 ± 8 years, 21 (50%) men] with a ratio of 7:3, while 61 patients [mean age: 60 ± 9 years, 42 (69%) men] from the other two institutions were enrolled for external validation. Radiomics features were extracted from global (all short-axis images from base-to-apex) left ventricular (LV) myocardium and three different segments (basal, midventricular, and apex) on short-axis LGE images using the phase-sensitive reconstruction (PSIR) sequence. The Boruta algorithm was used to select the radiomics features. This model was built using the XGBoost algorithm. The two readers performed qualitative and semiquantitative assessment of the LGE images based on the visual LGE patterns, while the quantitative assessment was measured using a dedicated semi-automatic CMR software. The diagnostic performance of the radiomics and other qualitative and quantitative parameters were compared by a receiver operating characteristic (ROC) curve analysis. A correlation between radiomics and the degree of myocardial involvement by amyloidosis was tested.ResultsA total of 1,906 radiomics features were extracted for each LV section. No statistical significance was indicated between any two slices for diagnosing CA, and the highest area under the curve (AUC) was found in basal section {0.92 [95% confidence interval (CI), 0.86–0.97] in the LGE images in the training set, 0.89 (95% CI, 0.79–1.00) in the internal validation set, and 0.92 (95% CI, 0.85–0.99) in the external validation set}, which was superior to the visual assessment and quantitative LGE parameters. Moderate correlations between global or basal radiomics scores (Rad-scores) and Mayo stage in all patients were reported (Spearman’s Rho = 0.61, 0.62; all p &lt; 0.01).ConclusionA radiomics analysis of the LGE images provides incremental information compared with the visual assessment and quantitative parameters on CMR to diagnose CA. Radiomics was moderately correlated with the severity of CA. Further studies are needed to assess the prognostic significance of radiomics in patients with CA.
Co-existing Hypertension and Hyperhomocysteinemia Increases the Risk of Carotid Vulnerable Plaque and Subsequent Vascular Event: An MR Vessel Wall Imaging Study
Authors: Li Dongye , Qiao Huiyu , Yang Xieqing , Li Jin , Dai Wei , Chen Xiaoyi , Shen Jun , Zhao Xihai 
Published: March 2022

PurposeThis study sought to determine the associations of co-existing hypertension and hyperhomocysteinemia (H-Hcy) with carotid vulnerable plaque features and subsequent vascular events.MethodsSymptomatic patients with carotid atherosclerosis were enrolled and underwent carotid magnetic resonance (MR) vessel wall imaging. The patients were divided into the following groups: co-existing hypertension and H-Hcy group; isolated hypertension group; isolated H-Hcy group; and control group. The morphological and compositional characteristics of carotid plaques were assessed on MR images and compared among different groups. Univariate and multivariate cox regressions were used to calculate the hazard ratio (HR) and corresponding 95% confidence interval (CI) of co-existing hypertension and H-Hcy in predicting subsequent vascular events after at least 1-year followed-up.ResultsIn total, 217 patients (mean age, 59.4 ± 11.9 years; 154 males) were recruited. Patients in co-existing hypertension and H-Hcy group had a significantly higher prevalence of carotid lipid-rich necrotic core (LRNC) than isolated H-Hcy and control group (73.2 vs. 43.3 vs. 50%, p = 0.015). During the median follow-up time of 12.2 ± 4.3 months, 61 (39.8%) patients experienced vascular events. After adjusting for baseline confounding factors, co-existing hypertension and H-Hcy (HR, 1.82; 95% CI, 1.01–3.27; p = 0.044), presence of carotid LRNC (HR, 2.25; 95% CI, 1.09–4.65; p = 0.029), and combination of co-existing hypertension and H-Hcy and carotid LRNC (HR, 2.39; 95% CI, 1.26–4.43; p = 0.007) were significantly associated with subsequent vascular events.ConclusionsCo-existing hypertension and H-Hcy are associated with carotid vulnerable plaque features, such as LRNC. Combining co-existing hypertension and H-Hcy with carotid vulnerable plaque features has a stronger predictive value for subsequent vascular events than each measurement alone.
Prognostic Outcomes in Acute Myocardial Infarction Patients Without Standard Modifiable Risk Factors: A Multiethnic Study of 8,680 Asian Patients
Authors: Kong Gwyneth , Chew Nicholas W. S. , Ng Cheng Han , Chin Yip Han , Lim Oliver Z. H. , Ambhore Anand , Ng Gavin , Kong William , Poh Kian-Keong , Foo Roger , Yip James , Yeo Tiong-Cheng , Low Adrian Fatt-Hoe , Lee Chi-Hang , Chan Mark Yan-Yee , Tan Huay-Cheem , Loh Poay-Huan 
Published: March 2022

BackgroundAn increasing proportion of patients with acute myocardial infarction (AMI) are presenting without standard modifiable risk factors (SMuRFs) of hypertension, hypercholesterolemia, diabetes, and smoking, but with an unexpectedly increased mortality. This study examined the SMuRF-less patients presenting with AMI in a multiethnic Asian population.MethodsWe recruited patients presenting with AMI from 2011 to 2021 and compared the prevalence, clinical characteristics, and outcomes of SMuRF-less and SMuRF patients. Multivariable analysis was used to compare the outcomes of 30-day cardiovascular mortality, all-cause mortality, readmission, cardiogenic shock, stroke, and heart failure. Kaplan–Meier curves were constructed for 30-day cardiovascular mortality, with stratification by ethnicity, gender and AMI type, and 10-year all-cause mortality.ResultsStandard modifiable risk factor-less patients, who made up 8.6% of 8,680 patients, were significantly younger with fewer comorbidities that include stroke and chronic kidney disease, but higher rates of ventricular arrhythmias and inotropic or invasive ventilation requirement. Multivariable analysis showed higher rates of cardiovascular mortality (HR 1.48, 95% CI: 1.09–1.86, p = 0.048), cardiogenic shock (RR: 1.31, 95% CI: 1.09–1.52, p = 0.015), and stroke (RR: 2.51, 95% CI: 1.67–3.34, p = 0.030) among SMuRF-less patients. A 30-day cardiovascular mortality was raised in the SMuRF-less group, with similar trends in men, patients with ST-segment elevation myocardial infarction (STEMI), and the three Asian ethnicities. All-cause mortality remains increased in the SMuRF-less group for up to 5 years.ConclusionThere is a significant proportion of patients with AMI without standard risk factors in Asia, who have worse short-term mortality. This calls for greater focus on the management of this unexpectedly high-risk subgroup of patients.
Identification of Ion Channel-Related Genes and miRNA-mRNA Networks in Mesial Temporal Lobe Epilepsy
Authors: Su Zhengwei , Li Yinchao , Chen Shuda , Liu Xianyue , Zhao Ke , Peng Ying , Zhou Liemin 
Published: March 2022

Objective: It aimed to construct the miRNA-mRNA regulatory network related to ion channel genes in mesial temporal lobe epilepsy (mTLE), and further identify the vital node in the network.Methods: Firstly, we identified ion channel-related differentially expressed genes (DEGs) in mTLE using the IUPHAR/BPS Guide to Pharmacology (GTP) database, neXtProt database, GeneCards database, and the high-throughput sequencing dataset. Then the STRING online database was used to construct a protein-protein interaction (PPI) network of DEGs, and the hub module in the PPI network was identified using the cytoHubba plug-in of Cytoscape software. In addition, the Single Cell Portal database was used to distinguish genes expression in different cell types. Based on the TarBase database, EpimiRBase database and the high-throughput sequencing dataset GSE99455, miRNA-mRNA regulatory network was constructed from selected miRNAs and their corresponding target genes from the identified DEGs. Finally, the rats were selected to construct chronic li-pilocarpine epilepsy model for the next stage experimental verification, and the miR-27a-3p mimic was used to regulate the miRNA expression level in PC12 cells. The relative expression of miR-27a-3p and its targeting mRNAs were determined by RT-qPCR.Results: 80 mTLE ion channel-related DEGs had been screened. The functional enrichment analysis results of these genes were highly enriched in voltage-gated channel activation and ion transport across membranes. In addition, the hub module, consisting of the Top20 genes in the protein-protein interaction (PPI) network, was identified, which was mainly enriched in excitatory neurons in the CA3 region of the hippocampus. Besides, 14 miRNAs targeting hub module genes were screened, especially the miR-27a-3p deserving particular attention. miR-27a-3p was capable of regulating multiple mTLE ion channel-related DEGs. Moreover, in Li–pilocarpine-induced epilepsy models, the expression level of miR-27a-3p was increased and the mRNAs expression level of KCNB1, SCN1B and KCNQ2 was decreased significantly. The mRNAs expression level of KCNB1 and KCNQ2 was decreased significantly following PC12 cells transfection with miR-27a-3p mimics.Conclusion: The hub ion channel-related DEGs in mTLE and the miRNA-mRNA regulatory networks had been identified. Moreover, the network of miR-27a-3p regulating ion channel genes will be of great value in mTLE.
Discovery of Novel Circulating Immune Complexes in Lupus Nephritis Using Immunoproteomics
Authors: Tang Chenling , Fang Min , Tan Gongjun , Zhang Shu , Yang Bowen , Li Yaxi , Zhang Ting , Saxena Ramesh , Mohan Chandra , Wu Tianfu 
Published: March 2022

ObjectiveThe goal is to discover novel circulating immune complexes (ICx) in the serum of lupus nephritis (LN) as potential biomarkers.MethodsProtein A/G magnetic beads or C1q-coated plates were used to capture ICx in the serum of LN, followed by the identification of immunoglobulin-binding proteins using liquid chromatography and tandem mass spectrometry (LC-MS/MS). Bioinformatic approaches and single-cell RNA sequencing (scRNA Seq) databases were used to select potential candidate ICx markers in LN. The selected ICx markers were further validated using ELISA.ResultsA total of 300 immunoglobulin-binding proteins were discovered in the screening, among which 77 proteins were detectable only in LN samples. Bioinformatics-assisted selection allowed us to further identify 10 potential immunoglobulin-binding proteins, which form ICx as potential biomarkers in LN. In a validation cohort of 62 LN patients and 21 healthy controls (HC), we found that prolyl 3-hydroxylase 1 (P3H1), phosphatase and actin regulator 4 (PHACTR4), and regulator of G-protein signaling 12 (RGS12) ICx exhibited discriminative capability in distinguishing LN from HC, with an area under the curve (AUC) values of 0.82, 0.99, and 0.90, respectively. Furthermore, a biomarker panel comprising CD14, CD34, cystatin A, myocyte enhancer factor 2C (MEF2C), RGS12, and ubiquitin C (UBC) ICx could distinguish active LN from inactive LN with an AUC value of 0.85, which is comparable to or better than pathological parameters such as renal activity index (AI) and renal chronicity index (CI).ConclusionImmunoproteomics-based discovery studies have enabled us to identify circulating immune complexes as potential biomarkers of LN.
Remote Sensing of the Tautra Ridge: An Overview of the World’s Shallowest Cold-Water Coral Reefs
Authors: Mogstad Aksel Alstad , Løvås Håvard Snefjellå , Sture Øystein , Johnsen Geir , Ludvigsen Martin 
Published: March 2022

On the Tautra Ridge – a 39-100 m deep morainic sill located in the middle of the Trondheimsfjord, Norway – some of the world’s shallowest known occurrences of the scleractinian cold-water coral (CWC) Desmophyllum pertusum can be found. The earliest D. pertusum records from the Tautra Ridge date back to the 18th century, and since then, the location has provided easy access to physical coral specimens for numerous scientific studies. In 2013, the ridge was declared a marine protected area by the Norwegian Government due to its unique CWC reefs. However, few attempts have to our knowledge yet been made to characterize the distribution, extent and condition of these reefs extensively. The aim of the current study was therefore to add geospatial context to the Tautra CWC reef complex. In the study, data from multibeam echo sounding, synthetic aperture sonar imaging and underwater hyperspectral imaging are used to assess CWC reef occurrences from multiple perspectives. The study demonstrates how complementary remote sensing techniques can be used to increase knowledge generation during seafloor mapping efforts. Ultimately, predictive modeling based on seafloor geomorphometry is used to estimate both distribution and areal coverage of D. pertusum reefs along the majority of the Tautra Ridge. Our findings suggest that D. pertusum reef distribution on the Tautra Ridge is affected by several geomorphometric seafloor properties, and that the total reef extent in the area likely is close to 0.64 km2. Better description of current patterns across the Tautra Ridge will improve our understanding of the interaction between hydrography and geomorphology at the Tautra CWC reef complex in the future.