bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of three scoring systems for predicting renal prognosis in antineutrophil cytoplasmic antibody-associated glomerulonephritis
Authors: Wang Xinfang , Zhang Xiaofeng , Chen Lin , Ma Qiuling , Su Yajing , Liu Jingwen , Shi Huihui , Wang Ruiqiang 
Published: November 2022

Abstract
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) is characterized by rapidly progressive glomerulonephritis, and timely initiation of treatment and evaluation is critical to prevent progression of renal disease to end-stage renal disease (ESRD). This study aimed to evaluate the predictive value of the renal risk score (RRS), Birmingham vasculitis activity score (BVAS), and renal vascular lesions (RVLs) score for renal prognosis in AAGN.
Methods: A retrospective analysis of ninety-three patients diagnosed with AAGN after renal biopsy was performed. The RRS, BVAS, and RVLs score were evaluated in relation to clinicopathologic features and renal prognosis. A receiver operating characteristic (ROC) curve was used to evaluate their prognostic value for the kidneys.
Results: The median follow-up time was 36 months. Thirty-eight patients progressed to ESRD. Survival analysis showed that renal prognosis worsened within the RRS group in the order of low, medium, and high RRS (P＜0.05). Within the RVLs group, the renal prognosis of the groups with severe and moderate RVLs was worse than that of the group without RVLs (P = 0.017, P< 0.001), and the group with mild RVLs was close to that of the group without RVLs. ROC analysis showed that the AUC of RRS, BVAS, RVLs score, RVLs score combined with RRS (RVLs score & RRS, RR), RVLs score and RRS combined with BVAS (RVLs score & RRS & BVAS, RRB) were 0.862, 0.759, 0.618, 0.908, and 0.914, respectively. The predictive power of RRB and RR was comparable and significantly better than the RRS, BVAS, and RVLs score. On the basis of simplicity and validity, RR was selected as the best predictor, and the relationship between RRS, RVLs score, and RR was calculated using a linear fit, resulting in the linear equation RR = -0.4766 + 0.1231 × RVLs score + 0.395 × RRS (P < 0.001).
Conclusions:In AAGN, the predictive power of RR for renal prognosis was superior to that of RRS, BVAS, and RVLs score. RR may serve as a new predictor of renal prognosis in AAGN.
Experimental study on triaxial unloading mechanical properties and acoustic emission response of shale with different water contents
Authors: Li Bingyang , Yang Fengwei , Li Haofei , Du Pengzhao , Liu Zhenhong 
Published: November 2022

Abstract
Water is one of the most significant factors influencing the mechanical properties of rocks. Triaxial unloading acoustic emission (AE) tests were performed to study the unloading mechanical characteristics and damage evolution mechanism of shale with various water contents. The damage evolution characteristics of shale under triaxial unloading conditions were analyzed using AE time series parameters. The results show that when the water saturation coefficient rises, the number of AE rings and the energy value of shale decrease. Based on the results of the AE test, the ratios of the crack initiation stress and damage stress to the peak stress are 0.4 ~ 0.6 and 0.9, respectively. The closure stress, crack initiation stress, damage stress, and other characteristic stresses determined by the stress axial strain method and the AE method all decrease with the increase of the water saturation coefficient, demonstrating that water has a significant impact on the mechanical characteristics of the shale during the unloading damage and damage process. Based on the test results, a statistical damage constitutive model is established, and it uses the AE cumulative ringing count to represent the damage variable. The calculated results of the model are in good agreement with the experimental data, indicating that the established model can more accurately depict the evolution process of shale unloading damage and failure under different water contents. The study's findings can be used as a reference for determining the extent of rock damage caused by water-rock interaction.
Characterization of Exosomes Isolated from Non-Small Lung Cancer Cell (NC1975) using Improved Morphological and Surface Protein Biomarkers methods
Authors: Mahgoub Ilham , Abdella Galal M. 
Published: November 2022

Abstract
Lung cancer is considered one of the leading causes of death worldwide. Usually, disease detection is difficult in the early stages; new methods for diagnosis using non-invasive ways are developed using Nano-molecules called exosomes. Exosomes are cell-derived vesicles carrying different molecules (proteins, DNA, RNA, microRNA) and displaying many proteins on their membrane surfaces. In this study, NCI 1975 Cells line has been used as a source of exosomes. First, the isolation processes were carried out using different ultra-centrifugation devices. Then isolated exosomes were characterized using surface protein biomarkers. Finally, the Exosome isolated products were screened under Transmission Electron Microscopy (TEM) and compared with Scanning Electron Microscopy (SEM). The results showed that the size distributions of apoptotic vesicles (APV) 450nm and necrotic bodies (NCB) 280 nm (extracellular vesicles )were significantly different from exosomes(P < 0.001). This study confirmed the accessible use of exosomes in the diagnosis and prognosis of Non-Small Cell Lung Cancer (NSCLC).
Differential influence of temperature on the toxicity of three insecticides against the codling moth Cydia pomonella (L.) and two natural enemies
Authors: Perrin Marie , Borowiec Nicolas , Thaon Marcel , Siegwart Myriam , Delattre Thomas , Moiroux Joffrey 
Published: November 2022

Abstract
Insecticide toxicity may strongly vary with temperature, and interspecific differences have been commonly reported for this relationship. A differential influence of temperature on insecticide toxicity between pests and their natural enemies may have important consequences on biological control in a global warming context. This study aimed to investigate cross effects between temperature and three insecticides - i.e., chlorantraniliprole, emamectin and spinosad - on the mortality of a major pest in orchards, Cydia pomonella L., and two of its natural enemies in southern France, the predatory earwig Forficula auricularia L. and the introduced parasitoid Mastrus ridens Horstmann. We observed a decreased efficiency of emamectin and spinosad with increasing temperature on mortality of codling moth, while no influence of temperature on chlorantraniliprole efficacy was observed. Increasing temperatures increased the toxicity of all insecticides against M. ridens and only for emamectin on F. auricularia. This study provides essential insight to make recommendations for using these insecticides in combination with two natural enemies to control the codling moth in a warming world. Our results suggest that the use of spinosad may become sub-optimal under higher temperatures. In contrast, chlorantraniliprole should remain suitable under warmer climatic conditions to control C. pomonella, conserve F. auricularia and facilitate the establishment of M. ridens. For conservation biological control relying on F. auricularia, alternating use of emamectin during early spring, when its toxicity is the lowest on this natural enemy, and chlorantraniliprole during summer could limit resistance risks in codling moth populations and reduce the insecticides' impact on the populations of natural enemies.
Remediation of Pb-contaminated soil using Biochar-Based Slow- Release P Fertilizer and biomonitoring employing bioindicators
Authors: Luque María Paula Acosta , López Julián E. , Henao Nancy , Saldarriaga Juan F. 
Published: November 2022

Abstract
Soil contamination by Pb can result from different anthropogenic sources such as lead-based paints, gasoline, pesticides, coal burning, mining, among others. This work aimed to evaluate the potential of P-loaded biochar to remediate a Pb-contaminated soil and to apply a biomonitoring alternative after soil remediation. First, rice husk-derived biochar was obtained at different temperatures (450, 500, 550, and 600 ºC). Then, part of the resulting material was activated. Later, the raw biochars and activated biochars were immersed in a saturated KH2PO4 solution to produce P-loaded biochars. The ability of materials to immobilize Pb and increase the bioavailability of P in the soil was evaluated by an incubation test. The materials were incorporated into doses of 0.5, 1.0, and 2.0%. After 45 days, soil samples were taken to biomonitor the remediation process using two bioindicators: a phytotoxicity test and enzyme soil activity. Activated P-loaded biochar produced at 500 ºC has been found to present the best conditions for soil Pb remediation. This material significantly reduced the bioavailability of Pb and increased the bioavailability of P. The phytotoxicity test and the soil enzymatic activity were significantly correlated with the decrease in bioavailable Pb but not with the increase in bioavailable P. Biomonitoring using the phytotoxicity test is a promising alternative for the evaluation of soils after remediation processes.
Optimization of the air-conditioning energy performance and daylight performance of a residential building according to the bioclimatic design principles: An application to the Moroccan Mediterranean climate
Authors: Ameur Mohamed , Kharbouch Yassine , Taoukil Driss , Mimet Abdelaziz 
Published: November 2022

Abstract
The bioclimatic architecture concept refers to an approach that takes into account the various characteristics of a building environment to make it more comfortable for its occupants. This work aims to improve the passive design parameters of an air-conditioned residential building located in the north of Morocco, in accordance with bioclimatic principles. The bioclimatic chart diagram is used to select the passive design measures that are the most appropriate for the north Morocco climate characteristics. Then, a set of design parameters are selected for more delimitation in the optimization study. The optimization problem is multi-objective and aims to find the design solution that simultaneously includes the best air-conditioning energy performance and daylight performance. The obtained results showed that the multi-objective optimum design solution is characterized by massive walls and roof, exterior insulation, double window glazing type, and a high summer ventilation rate. Also, a small glazing area with a large sun-shading covering is needed for the east facade. Ultimately, the building performance analysis revealed that the optimum bioclimatic design solution fully meets the requirements established by the Moroccan Building Thermal Regulation (MBTR), leading to an energy performance improvement of about 52%.
A novel TPD52L2-ROS1 gene fusion expanding the molecular alterations in inflammatory myofibroblastic tumor: case report and literature review
Authors: Liu Xuguang , Duan Yaqi , Wang Guoping , Zhu Pengcheng 
Published: November 2022

Abstract
Background: Inflammatory myofibroblastic tumor (IMT) is a distinctive tumor composed of spindle cells accompanied by mixed inflammatory cells, and immunohistochemical positivity for ALK (anaplastic lymphoma kinase protein) can be detected in half of IMTs. The diagnosis of ALK-negative IMT could be a challenge. Recently, the fusions of some kinase genes, such as RET, NTRK1, ROS1, etc., are revealed in ALK-negative IMT.
Case presentation: A 19-year-old woman presented with swelling of the left upper arm. Magnetic resonance imaging (MRI) scan revealed a tumor in the left postbrachium extended to the left axillary, serratus anterior muscle, and latissimus dorsi muscle. Histopathologically, the irregular-circumscribed tumor was composed of dense spindle-shaped cells with eosinophilic abundant cytoplasm and hyalinized mesenchyme in an inflammatory background. Immunohistochemically (IHC), tumor cells were positive for SMA, MDM2, and p16; the cells were negative for desmin, MyoD1, Myogenin, pan-cytokeratin, S100, SOX10, HMB45, Malen-A, CD34, CD31, CD99, and ALK. By RNA-based NGS, a novel fusion between TPD52L2 3’ end of exon 1-4 and ROS1 5’ end of exon 36-43 was revealed. ROS1 IHC staining was negative. The final diagnosis of IMT with TPD52L2-ROS1fusion was made.Subsequently, the patient experienced a good clinical response to Crizotinib, and clinical follow-up showed stable disease after 9 months.
Conclusion: This report expands the spectrum of ROS1 gene rearrangements in the IMT and highlights the importance of molecular analysis of IMT for getting a diagnostic clue and determining potential therapeutic strategies.
Longitudinal weight status, and academic achievement
in elementary schoolchildren in the United States
Authors: Elish Paul , Boedeker Peter , Lash Timothy , Gazmararian Julie 
Published: November 2022

Abstract
Background/Objectives. Childhood overweight and obesity have a well-established negative impact on children’s health. Overweight and obesity might also negatively impact children’s academic performance, but existing literature on this association is inconclusive. This study uses a longitudinal design in a large, diverse elementary school sample to rigorously test the association between longitudinal weight status and academic achievement. Analyses also investigate modification by sex, race/ethnicity, and cardiorespiratory fitness (CRF).
Subjects/Methods. In a large suburban school district in the United States, 4 936 Grade 4 students were recruited. Demographic, course grade, and standardized test data were collected from school records for Grades 3 to 5, and body mass index (BMI) and CRF were assessed each year. Students wore accelerometers during the school day for up to 15 days across three semesters (Grade 4 Fall and Spring, Grade 5 Fall) to objectively measure physical activity. Multiple imputation addressed missing data and multilevel analyses controlled for student demographics and clustering within schools.
Results. Unadjusted multilevel models found small negative associations for students who were persistently obese with course grades and standardized test scores, but these associations largely disappeared when controlling for demographic characteristics. Residual associations for math and writing course grades were attenuated when controlling for CRF, though some marginal negative associations for math and writing remained for students who became obese during follow up. There was no evidence of modification by sex or race/ethnicity.
Conclusions Results suggest very small associations between obesity status and academic achievement that were largely explained by CRF. These findings support growing evidence that increasing CRF is more important than losing weight for improving children’s cognition and academic achievement.
Robotic total knee arthroplasty in clinical practice: protocol for a randomised controlled trial
Authors: Migliorini Filippo , Maffulli Nicola , Schäfer Luise , Schneider Jens , Nobili Andrea Maria , Kämmer Daniel , Michalak Milosch , Bell Andreas 
Published: November 2022

Abstract
Around 2–20% of patients who undergo total knee arthroplasty (TKA) reported restricted motion and anterior knee pain. Non-optimal implant components alignment represents a common cause for complain. In this context, the introduction of robotic assisted TKA is supposed to improve the accuracy of component positioning and to adapt more precisely to patient anatomy and biomechanics. Robotic TKA using has been introduced to improve component alignment, stability and proprioception. However, the advantages of robotic surgery over the conventional freehand TKA are still unclear and evidence are missing.
The present study is a protocol for a single-blind parallel-group randomized controlled trial in which each group of participants is exposed to only one of the study interventions. Patients will be randomly allocated to robotic TKA or standard TKA. The primary outcome of interest is to evaluate the learning curve. The secondary outcome of interest is to compare robotic TKA using CORI versus freehand arthroplasty in patients reported outcome measures (PROMs), length of the hospitalisation, blood values, implant positioning, blood transfusion units, range of motion. The third outcome of interest is to evaluate accuracy of component positioning of robotic TKA compared to the conventional TKA with respect to the pre-operative planning.
Level of evidence: Level I, randomised controlled trial
Registration: German Registry of Clinical Trials (ID: DRKS00030614)
Evaluation of the interaction between potent small molecules against the Nipah virus Glycoprotein in Malaysia and Bangladesh strains, accompanied by the human Ephrin-B2 and Ephrin-B3 receptors; a simulation approach
Authors: Ebrahimi Maryam , Alijanianzadeh Mahdi 
Published: November 2022

Abstract
In late September 1998 the first human case of Nipah virus (NiV) having been manifested in Malaysia with severe encephalitis and respiratory symptoms. Then, based on the viral genomic mutations two main strains (NiV-Malaysia and NiV-Bangladesh) have spread across the world. In the face of this biosafety level 4 pathogen with highly pandemic potential, no licensed molecular therapeutics have been approved. Considering the role of NiV attachment Glycoprotein in viral transmission, identifying small molecules that can be repurposed for inhibiting the Glycoprotein attachment, and also the viral receptors in human cells (Ephrin-B2 and Ephrin-B3) as the significant anti-NiV treatment were discussed. Thus, to prospect seven potential anti-COVID-19 drugs with clinical effectiveness (Pemirolast, Nitrofurantoin, Isoniazid Pyruvate, Eriodictyol, Cepharanthine, Ergoloid, and Hypericin) against NiV-G, Ephrin-B2, and Ephrin-B3 receptors, an annealing simulation, ligand-based pharmacophore modeling, and molecular docking simulations were implemented. Based on the annealing analysis, Pemirolast (pem) against efnb2 protein also Isoniazid Pyruvate (iso) against efnb3 receptor were repurposed as the best small molecule candidates. Moreover, Cepharanthine (ceph), and Hypericin (hyp) with noteworthy interaction values are the top Glycoprotein inhibitors in Malaysia and Bangladesh strains. Additionally, molecular docking calculation showed their binding affinity scores which are related to efnb2-pem (-7.1 kcal/mol), efnb3-iso (-5.8 kcal/mol), gm-hyp (-9.6 kcal/mol), gm-ceph (-10.1 kcal/mol), gb-ceph (-9.2 kcal/mol). Our computational research not only minimizes the challenge of time-consuming but also meets our precautionary demand for options to handle any new variants of the Nipah virus that might emerge in the future.
Automation of legal precedents retrieval: findings from a rapid literature review
Authors: Mentzingen Hugo , Bacao Fernando , António Nuno 
Published: November 2022

Abstract
Judges frequently rely their reasoning on precedents. In every circumstance, courts must preserve uniformity in case law and, depending on the legal system, previous cases compel rulings. The search for methods to accurately identify similar previous cases is not new and has been a vital input, for example, to case-based reasoning (CBR) methodologies. Innovations in language processing and machine learning (ML) brought momentum to identifying precedents while providing tools for automating this task. This rapid literature review investigated how research on the identification of legal precedents has evolved. It also examined the most promising automation strategies for this task and confirmed the growing interest in using artificial intelligence for legal precedents retrieval. The findings demonstrate that no artificial intelligence solution currently stands out as the most effective at finding past similar cases. Also, existing results require validation with statistically significant samples and ground truth provided by specialists. In addition, this work employed text mining (TM) to automate part of the literature review while still delivering an accurate picture of research in the field. Ultimately, this review suggests directions for future work, as more experimentation is required.
Transurethral recording of motor-evoked potential from urinary sphincter muscle during pediatric lumbosacral spine surgery
Authors: Ogawa Yuki , Hayashi Hironobu , Sasaki Ryota , Takatani Tsunenori , Oi Ayako , Uemura Keiko , Kawaguchi Masahiko 
Published: November 2022

Abstract
Purpose
Postoperative urinary dysfunction following lumbosacral spine surgery is devastating. To assess urinary function, we invented a pediatric urinary catheter equipped with electrodes for the direct transurethral recording of myogenic potential from the external urethral sphincter (EUS). This is the first report regarding the direct recording of motor-evoked potential (MEP) from EUS during lumbosacral spine surgery in children.
Methods
Two children (aged 2 and 6 years) were included in this study. One patient had no preoperative neurological dysfunction, while the other had frequent urination and urinary incontinence. A pair of surface electrodes was attached to a silicone rubber urethral catheter (6 or 8 Fr; diameter, 2 or 2.6 mm). The MEP from the EUS were recorded to assess the function of the centrifugal tract from the motor cortex to the pudendal nerve.
Results
Baseline MEP waveforms from the EUS were successfully recorded with latency and amplitude of 39.5 ms and 66 µV in patient 1 and 39.0 ms and 113 µV in patient 2, respectively. A significant decrease in amplitude was not observed during surgery in the two cases. No new urinary dysfunction and complications associated with the urinary catheter-equipped electrodes developed postoperatively.
Conclusion
Using an electrode-equipped urinary catheter, monitoring of MEP from the EUS could be applicable during lumbosacral surgery in pediatric patients.
Quality Aspects of Digital Forest Service Management: A Case Study
Authors: Jäntti Marko , Aho Markus 
Published: November 2022

Abstract
Forest industry plays a critical role for many remote rural regions in Nordic countries. Despite the increasing number of various digital transformation initiatives, many forestry organizations still use very tra- ditional non-digitalized work practices in harvesting, logging and support operations. Unfortunately, digital transformation is often performed as an ad hoc activity without a holistic approach to ensure ICT quality con- trol. In this paper, we aim to answer the research problem how digital transformation affects the quality of a forest machine operator’s opera- tional processes and service systems. A case study research method with a single case structure was used in this study. The main contribution of the paper is to show that digital transformation shall benefit not only the for- est machine operator organization but also their surrounding ecosystem by increasing transparency of operations, reducing travel costs, increas- ing productivity and creating a more proactive operating model. Both sociological and technical aspects of digital transformation are discussed in the context of forest service management. Additionally, we show that in order to succeed in digital transformation, forestry organizations must pay attention to various quality aspects holistically: hardware quality, software quality, service quality, data quality and process/project quality.