bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arsenic Remove from Apatite-Soil Treated Waters’ Using Magnetic Zero Valent Iron Doped Polyethersolfun Beads
Authors: Noorbakhsh Roya , Koohi Mohammad Kazem , Hasan Jalal , Rahmani Anoosheh , Nodeh Hamid Rashidi 
Published: July 2022

Abstract
The drop immerses calcium chloride aqueous solution was utilized to prepare the zero valent iron-doped polyethersulfone beads (PES/ZVI) for efficient removal of arsenic from apatite-soil treated waters’. The proposed beads can assist in promoting uptake efficiency by hindering ZIV agglomeration due to high porosity and different active sites. The PES/ZVI beads were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and vibrating sample magnetism (VSM). The objective of this manuscript was to develop new PES/ZVI beads with increased removal efficiency for the removal of arsenic ions from the apatite-soil treated waters’. Maximum arsenic removal of 82.39% was achieved when applied at an 80 mg dose for a contact time of 180 min and 90% after 300 min shaking time. The experimental process was fitted with the Langmuir model due to the high R2 (0.99) value compared to the Freundlich model (0.91) with an adsorption capacity of 41.32 mg.g− 1. The adsorption rate was limited by pseudo-second-order (R2 = 0.999) and the adsorption mechanism nature is endothermic and physical. Hence, isotherm, kinetic and thermodynamic studies revealed the feasibility of sorption and removal of arsenic through the physisorption process.
An Exploratory Study on Learner Agency and Second Language Writing Practices of Korean High School Students
Authors: Jang Jinsil 
Published: July 2022

Abstract
This qualitative study explores Korean English learners’ exercising of agency in processing and producing L2 writing. Data were collected from off-line and online interviews, field notes, and other written materials over the course of two years and analyzed from a social view of agency (Ahearn, 2010; van Lier, 2008). The students’ engagement in varied L2 writing projects and their writing artifacts consistently showed their enhanced awareness of linguistic and other semiotic resources which resulted in their frequent and continuous use of multiple languages and other placed resources. Meanwhile, they developed their strategies and reshaped their L2 writing practices considering the given context, placed resources, and their funds of knowledge. Findings from this study provide valuable insights into the open possibilities of EFL students’ exercise and development of agency, which is an increasingly necessary feature of life-ling learners in the post-pandemic era.
Delayed anterior tibial artery pseudoaneurysm following the corrective fibular osteotomy for knee osteoarthritis - A Case Report
Authors: Chang Chih-Wei , Chen Yu-Sheng , Yang Chyun-Yu , Chen Yen-Nien 
Published: July 2022

Abstract
Introduction: Proximal fibula osteotomy (PFO) has been recognized as a surgical alternative for treating medial compartment osteoarthritis of the knee. Related peroneal neuropathies were concerned despite relatively low complications after PFO. In our clinical practice, a modification of the osteotomy level was thus made without mentioned neurologic deficits. However, a rare case of vascular injury was encountered. Herein we present a rare anterior tibial artery (ATA) psuedoaneurysm after this corrective osteotomy.Case presentation: A 55-year-old male visited our emergent room, presenting a painful swelling over his right antero-lateral shin 13 days post PFO. Radiological investigations showed an ATA pseudoaneurysm and which was solved with endovascular repair.Discussion: The suggested osteotomed level of PFO prone the peroneal neuropathies, which could be avoided by the modified level of osteotomy. Despite similar relief of knee pain, a rare case of vascular complication, ATA psuedoaneurysm, was encountered. Considering the course of ATA, the osteotomy should start at the posterolateral corner of the fibula and aim toward the anterior tibia.Conclusion: Although PFO was a simple surgical procedure, not free of complications. Recent surgical history along with alarming vascular symptoms should arouse clinical suspicion and timely intervention.
Treatment strategies of patients with co-existing TB and LC: systematic reviews and meta-analysis
Authors: zhang hongjun , Li Wen-jie , Chen Yan-wei , Chai Ya-qin , Zhao Yan-jun , Gu Xing 
Published: July 2022

Abstract
Purpose: Treatment strategies of patients with co-existing tuberculosis (TB) and lung cancer (LC) is still not conclusive, especially for advanced non-small cell lung cancer (NSCLC) patients with synchronous or not anti-TB and anti-cancer treatments. This systematic review and meta-analysis aim to assess treatment regimen and arrangement, the efficacy and safety of anti-cancer and anti-TB treatment in NSCLC patients with concomitant active TB.Methods: A Systematic and comprehensive search was performed in the following databases: PubMed, Embase, and Web of Science, in articles and abstracts published from 1929 to 2022. Six articles (involving 261 co-existing TB and LC cases and 8681 LC controls) met the inconclusive criteria. Review Manager version 5.4 (RevMan; Cochrane, Lindon, UK) software and Stata version 17.0 software were used for this statistical analysis.Results: The result of this meta-analysis demonstrates that LC patients with PTB appear to have had poor clinical response to treatment (log OR = 0.32, 95% confidence interval [CI] 0.03 - 0.61, p= 0.03, I2=8.68%). The results showed that lung cancer patients with TB infection had more adverse events (AEs) related to Immune-checkpoint inhibition (ICI), chemotherapy, or target drug treatment (log RR=0.11, 95% CI=0.001–0.02, p= 0.04, I2=38.84%). However, after removing AEs related to ICI treatment, other AEs of any grade were similar in patients with or without PTB treated with chemotherapy or target drug (log RR=0.07, 95% CI=-0.04–0.18, p=0.64, I2=0.00%). Timing to anti-cancer therapy: for 39.0% (102/261) of patients, at least 1-4 weeks after the start of anti-TB therapy; for 3.4% (9/261) of patients, at 2 weeks before the start of anti-TB treatment; for 14.6% (38/261) of patients, at received the anti-TB treatment at the same time.Conclusion: The present meta-analysis demonstrated that LC patients with TB have a poorer treatment response than those without TB; LC patients with TB receiving first-line chemotherapy or targeted therapy and anti-TB treatment at least 1-4 weeks after the start of anti-TB treatment or at the same time will not increase the incidence of AEs.
The Positive Psychological Capital and its Influencing Factors among University Students during the COVID-19 pandemic
Authors: Ren Xiaohong , Wu Dapeng , He Ping , Luo Wenxiu , Zhao Jiayu , cen Yu , Su Keju , Du Chengzhao , Wu Yiyan , Zhu Huaiyi , Wang Xinyue , Yang Liqiu , Xia Lijie , Zeng Runxin , Wen Leling , Zheng Wanli , Yang Yan , Luo Jiaming 
Published: July 2022

Abstract
Background: Little research has been done on the mental health of western Chinese university students during the Coronavirus disease (COVID-19) pandemic. This work aims to fill the gap by gaining insight into the positive psychological capital and its influencing factors among university students in western China during the COVID-19 pandemic. Methods: An online cross-sectional study was conducted in college students from a medical school. Participants were surveyed anonymously using a general information questionnaire and the Positive Psychological Capital Scale. The key factors and models affecting the psychological capital were obtained by using the gradual regression method. If P < 0.05, the difference would be considered statistically significant. Results: The total score of positive psychological capital among university students in western China was 118.51±16.91, Taking the psychological capital as the dependent variable, gender and grade as the independent variables, the key factors and models affecting the psychological capital were obtained by using the gradual regression method.The results showed that the P-value of each influencing factor was <0.05. The key influencing factors of psychological capital of college students were gender and and place of residence. Conclusion: The overall positive psychological capital of college students in western China was in good condition during the pandemic, with large room for improvement though. Gender and Residence were independent influencing factors on the positive psychological capital.
Biotransformation pathway and side reaction engineering for the whole-cell production of glycolic acid from formaldehyde
Authors: Jo Hye-Jin , Yu Hanna , Kim Jun-Hong , Cheon Huijin , Kim Jeong-Sun , Park Jin-Byung 
Published: July 2022

Abstract
A very simple biocatalytic system for the synthesis of the industrially relevant C2 chemicals (e.g., glycolic acid (3)) from formaldehyde (1) was established by whole-cell biocatalyst. The biocatalytic system consisted of an engineered glyoxylate carboligase from Escherichia coli K-12 (EcGCL) and an aldehyde dehydrogenase (e.g., AldA from E. coli K-12). To improve glycolic acid production, we have investigated metabolic engineering to regulate substrate consumption and product bypass and E. coli-based strain optimization. The target compound was produced at rates of up to 20.3 U/g dry cells with conversions up to 92%. This study will ensure the sustainability of the green energy industry by synthesizing valuable C2 chemical from a single carbon compound, formaldehyde.
Proteomic analysis of colon cancer reveals the classical lipogenic pathway has prognostic and therapeutic opportunities
Authors: Srivast Sanjeeva , Barpanda Abhilash , Biswas Deeptarup , Verma Ayushi , Parihari Shashwati , Singh Avinash , Kapoor Shobhna , Kantharia Chetan 
Published: July 2022

Abstract
Despite recent advancements, the high mortality rate remains a concern in colon cancer (CAC). Identification of prognostic markers could prove to be a great asset in CAC management. Our previous work including several other studies has identified de novo lipogenesis (DNL) with increased FASN activity in CAC progression, but only a few have comprehensively investigated its role in disease pathobiology. This study aims to establish the prognostic as well as the therapeutic potential of DNL and associated signaling cascades in CAC. The key lipogenic enzymes FASN and ACLY were quantified using parallel reaction monitoring in tumors along with their matched controls and peptide intensities were used for class prediction analysis. A panel containing 12 unique peptides was identified with the ability to differentiate between CAC and controls with an accuracy of ~0.8. Furthermore, cerulenin-mediated suppression of the DNL in HCT116 cells revealed its multifunctional significance in cancer proliferation and metastasis. The inhibition affected various cellular signaling pathways, including cancer metabolic processes. The study revealed apoptosis induction through the up-regulation of Ub-proteasome machinery upon DNL inhibition. Again, in silico molecular docking-based drug repurposing was performed to find potential drug candidates. Furthermore, we have demonstrated that blocking DNL could be explored as a therapeutic option in CAC treatment.
A phase III study of HR-positive/HER2-negative and lymph node-positive breast cancer non- responsive to primary chemotherapy: a randomized clinical trial
Authors: Yang Yang , He Yingjian , Fan Zhaoqing , Chen Xue , Liu Yiqiang , Zhang Chao , Jiang Hongchuan , Wang Xin , Wang Xiang , Xie Fei , Wang Shu , Luo Bin , Kang Hua , Wang Tao , Jiang Zefei , Yuan Peng , Xu Binhe , Xu Ling , Liu Yinhua , Li Jinfeng , Xie Yuntao , Wang Tianfeng , Ouyang Tao 
Published: July 2022

Abstract
Background: We evaluated the use of pathological response-guided non-cross-resistant adjuvant chemotherapy in patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-)/lymph node-positive (LN+) breast cancer who were non-responsive to primary chemotherapy.
Methods: A multi-center, open-label, randomized, controlled phase III trial was conducted. Patients with HR+/HER2−/LN+ breast cancer and non-responsive to four cycles of neoadjuvant chemotherapy (Miller and Payne grade (G) 1 to G3 or any Miller and Payne grade but with residual positive lymph nodes in surgical specimens) were randomly assigned to receive four cycles of non-cross-resistant regimen plus endocrine therapy, or endocrine therapy alone. Patients with Miller and Payne G4 or G5 and LN− status were assigned to the observation group. Distant disease-free survival was the primary endpoint.
Results: Of the 433 patients enrolled between October 2010 and September 2018, 391 were non-responsive to treatment, and the final intention-to-treat analysis comprised 379 patients (chemotherapy plus endocrine therapy group, n=187; endocrine therapy-alone group, n=192). Forty patients responsive to neoadjuvant chemotherapy were assigned to the observation group. After a median follow-up period of 72.4 months, the 5-year distant disease-free survival was 92% (95% confidence interval [CI], 88–96%) and 90% (95% CI, 86–94%) in the chemotherapy plus endocrine therapy and endocrine therapy-alone groups, respectively (hazard ratio 0.79, 95% CI 0.45‒1.37; P=0.401). There was no significant difference between any of the prespecified subgroups. Compared to these two randomized groups, the observation group showed a trend towards better distant disease-free survival (P=0.107).
Conclusions: For patients non-responsive to neoadjuvant chemotherapy, adjuvant non-cross-resistant chemotherapy did not significantly improve distant disease-free survival compared to endocrine therapy alone. Trial registration: The trial was registered on November 25, 2009, at ClinicalTrials.gov, and the registration number was NCT01019616. https://clinicaltrials.gov/ct2/show/NCT01019616?term=alternative+non-cross-resistant&draw=2&rank=1
Drivers of Bilateral Climate Finance Aid: The Roles of Paris Agreement Commitments and Public Governance
Authors: Yuan Cheng , Xuehui Han 
Published: July 2022

Abstract
Using granular data from the OECD from 2010 to 2018 that differentiate between adaptation and mitigation measures to address climate change, we employed a double-hurdle model to examine whether countries’ Paris Agreement commitments and governance capacity help attract international climate-change-related financial aid. We found that (i) countries received a short-term aid boost in the year when they submitted the nationally determined contribution, and countries that committed only to action targets rather than emission goals were more likely to receive funds; (ii) both the quality of the budget and financial management and the quality of public management significantly enhanced the likelihood of receiving aid, but only the quality of public management contributed to attracting funding for adaptations; and (iii) multilateral institutions played catalytic roles in fostering bilateral international climate-change aid, particularly by increasing the likelihood of funding.JEL: O13; O19; Q54; H83.
Clinical study to verify the effectiveness and safety of the modified isothymol or carvacrol compound against SARS-CoV-2 in COVID-19 patients
Authors: OJEDA RAUL A 
Published: July 2022

Abstract
BACKGROUNDAlthough several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (COVID-19), none have yet been shown to be efficacious.METHODSWe conducted a double-blind, randomized, placebo-controlled trial of isothymol in adults hospitalized with Covid-19 with evidence of lower respiratory tract involvement. Patients were randomly assigned to receive either isothymol (6mg/ml) or placebo for up to 15 days. The primary outcome was the time to recovery, defined by either discharge from the hospital or hospitalization for infection-control purposes only.RESULTSA double-blind, randomized, controlled trial with placebo and modified isothymol was conducted in adults who were hospitalized with COVID-19. Patients were randomized to receive isothymol (6 mg/ml) or placebo for up to 15 days. The primary outcome was recovery time, defined by discharge from the hospital. The results of the 600 patients (300 assigned to isothymol and 300 to placebo) with data available after randomization suggest that those who received isothymol had a median recovery time of 7 days (95% confidence interval [CI], 5 to 9), compared with 14 days (95% CI, 11 to 15) in those who received placebo (recovery rate ratio, 1.24; 95% CI, 0.78 to 1.87; P <0.001). The Kaplan-Meier estimates of mortality at 15 days were 0% with isothymol and 4% with placebo. No serious adverse events were reported in patients in the isothymol group who underwent randomization and in 13 of the 300 patients in the placebo group who underwent randomization (4.33%). Ex vivo analysis of blood plasma shows a close relationship between hypersensitivity of inflammatory mediators (macrophages and type I interferons) and significantly elevated histamine production, as evidenced by autophosphorylation and increased IL-6 production in blood monocytes. of patients with severe COVID-19 compared to blood monocytes from healthy volunteers.CONCLUSIONSIsothymol was superior to placebo in shortening the time to recovery in adults hospitalized with Covid-19 and evidence of lower respiratory tract infection. (Funded by the Venezuelan Institute for Scientific Research, IVIC; ISRCTN Registry number, ISRCTN15363958.)
PU Adjacent Subcarriers Power Allocation for Controlling Interference of OFDM-CR Systems
Authors: Bepari Dipen , MONDAL SOUMEN , Chattopadhyay Ananya 
Published: July 2022

Abstract
Interference is the primary limiting factor of Cognitive Radio (CR) systems. This paper proposes a new power allocation idea for orthogonal frequency division multiplexing (OFDM)-based CR systems to control the interference to the licensed primary users (PUs) caused for allowing cognitive users (CUs) to use a licensed band temporarily. The idea is redistribute the power among a minimum number of PU adjacent subcarriers’. This idea has been implemented to modify two existing power loading schemes, and developed an evolutionary Genetic Algorithm (GA)-based power distribution method for maximizing CR system capacity of (i) a single PU, and (ii) multiple PUs CR paradigm under the constraint of total power budget, individual sub-channel power budget and, PU interference tolerance limit. Simulation results authenticated that the CU capacity improvement significantly depends on channel gain quality (good’ or bad’) of the PU adjacent subcarriers.
Modern biophysical view of electromagnetic processes of the phenomenon of life of living biological systems as a promising basis for the development of complex medicine: the role of cell membranes
Authors: Nevoit Ganna , Bumblyte Inga Arune , Potyazhenko Maksim , Minser Ozar 
Published: July 2022

The results of a theoretical study of the role of cell membranes in electromagnetic generation and in the process of realizing the phenomenon of life are presented in the article. The aim of the theoretical study was to summarize the existing scientific physical and biological knowledge of modern science about the electromagnetic processes of the phenomenon of life at the cellular level in order to deepen the fundamental knowledge of complex medicine. This study is a fragment of research work on “The development of algorithms and technologies for implementing a Healthy Lifestyle in patients with Noncommunicable Diseases based on the study of functional status” (state registration number 0121U108237: UDC 613 616-056-06: 616.1/9-03). General scientific methods and theoretical methods were used in this theoretical study. The main conclusions of the theoretical study were made as follows: 1) Cell membranes can be considered one of the main morphological structures of electromagnetic generation at the cellular level. 2) Cell viability is ensured by electromagnetic generation and electromagnetic generation of cells can be considered as a separate important function of membranes in addition to those already defined, as it provides signaling. 3) The end result of electromagnetic generation of cell membranes and all molecules of the cell is its own electromagnetic fields, which have a millimeter wavelength range with a frequency of 1010-1011 Hz and they are a quantum mechanical result of electromagnetic generations, perform the information-energy function in intercellular interaction in vivo.
High-rate partial denitrification via effluent residual nitrate controlling and microbial mechanism of nitrite accumulation by carbon dosage optimization
Authors: Chen Xiang , Lai Cheng , Wang Xinyi , Chen Guimei , Zhang Dachao 
Published: July 2022

AbstractThe high-rate partial denitrification (PD) via effluent residual nitrate controlling by carbon dosage optimization was investigated based on the analysis of microbial mechanism of nitrite accumulation in this study. When the COD/N was changed from 4.0 to 1.8 and the effluent nitrate was above 8.48 mg/L, the nitrate accumulation ratio (NAR) and nitrate removal ratio (NRR) achieved 60 and 90%, respectively. With the electron donor starvation (EDS) strategy, nitrite accumulation was increased, which is related to the reduced utilization of carbon sources. In addition, the rapid increase of Thauera (0.21% to 53.29%) and inhibition of Others and Unclassified (96.93% to 16.99%), and the significantly different expression between reductase genes contributed to nitrite production (narG, 1,727.44 copies/mg) and nitrite reduction (nirS, 208.27 copies/mg; nirK, 203.94 copies/mg) commonly involved in PD start-up and stable operation. Another reactor can be quickly started by controlling effluent residual nitrate within 19 days.
Textile dyeing wastewater treatment by Penicillium chrysogenum: Design of a sustainable process
Authors: Lanfranconi Ines , Ceretta María Belén , Bertola Nora , Wolski Erika Alejandra , Durruty Ignacio 
Published: July 2022

Abstract
In this work a parametric study and a bench bioreactor degradation test of Direct Black 22 (DB22) by Penicillium chrysogenum was performed as a first approach to an industrial application, framed within a policy of sustainable processes development. Three ancillary carbon sources and their optimum initial concentrations were studied. These were: glucose, potato starch and potato industry wastewater. Their optimum initial concentration was 6 g/L. The use of potato starch as co-substrate showed the highest decolorization rate and COD removal. Degradation of DB22 using different immobilization supports (stainless steel sponge, loofah sponge and polyethylene strips) was studied and the results showed that the time needed for the treatment decreased from 6 to 4 d. Phytotoxicity was evaluated in the final products of the immobilized cells assays, using Lactuca sativa seeds. For all treatments phytoxicity was reduced with respect to the untreated wastewater, except for the assays using polyethylene strips. Finally, the reuse of the biomass attached to different carriers and the performance of the treatment of DB22 in a 1 L bench scale bioreactor were tested. P. chrysogenum decolorized at least four sucesives reuses. The reactor assays showed a better performance of the treatment.