bluuebunny/crossref_metadata_2025_split huggingface dataset:
An in vitro evaluation of antimicrobial activity of a fast-setting endodontic material
Authors: Ji Mengzhen , Chi Yaqi , Wang Ye , Xiong Kaixin , Chen Xuan , Zou Ling 
Published: September 2022

AbstractThe aim of this study is to evaluate the antimicrobial activity of the fast-setting iRoot Fast Set Root Repair Material (iRoot FS), Mineral trioxide aggregate (MTA) and Biodentine. The materials were freshly mixed or set for 1 and 7 days to conduct the agar diffusion test, direct contact test and carry-over effect test againstE. faecalisandP. gingivalis, and the pH values were also measured. The data were analyzed by an analysis of variance and one-way ANOVA or Dunnett’s T3 test, and the Tukey’s post hoc test for multiple comparisons (α = 0.05). In the direct contact test, all three materials showed good antibacterial activity after setting for 20 min. The antibacterial properties of the three materials decreased with the increase of setting time (p < 0.05). The suspension of all the three materials showed high pH values (11–12) and no significant difference was observed (p > 0.05). With the extension of setting time, the pH of iRoot FS and Biodentine slightly decreased (p < 0.05). Fresh iRoot FS, Biodentine, and MTA killedE. faecalisandP. gingivaliseffectively, but their antimicrobial effect decreased after 24 h, and distinctly decreased after 7 days after mixing. iRoot FS, Biodentine, and MTA showed a tendency of alkalinity during this 7-day experiment.
Waste slag benefits for correction of soil acidity
Authors: Ghisman Viorica , Muresan Alina Crina , Buruiana Daniela Laura , Axente Elena Roxana 
Published: September 2022

AbstractThe global trend is to find new materials with improved environment friendly. The sustainable development of 2030 AGENDA and Waste Management Legislation sustain the disposal of a large quantity of slag at landfill sites by causing environmental consequences which has drawn attention to the need for its more effective recycling. Heavy industries have been operating in the Galati area for over 30 years and an ecological education is necessary for an efficient management of waste slag. The agricultural land resources are an issue world-wide and through this investigative study we showed that the mixture of blast furnace slag and waste slag dumped in landfill can help remediation of the soil acidity and increasing the crop yield. The chemical, structural and morphological properties of three investigated different slag samples are evaluated for recycling in agriculture. Results indicated that the obtained mixture of the slag waste dumped in landfill and of granulated metallurgical slag shows its usage in saving the affected lands. Therefore, by elemental analysis determined by X-ray fluorescence analytical equipment, the optimum weight ratio for the composition of soil-slag mixture were achieved. The obtained mixture presents a balance between soil pH = 5.2 corresponding to a medium acid soil and slag pH = 12.5 which corresponds as strongly basic character which is beneficial in amelioration process of acidic soils for the improving of soil characteristics.
Study on protective performance and gradient optimization of helmet foam liner under bullet impact
Authors: Huang Xingyuan , Zheng Qiujie , Chang Lijun , Cai Zhihua 
Published: September 2022

AbstractProtective equipment in war plays a vital role in the safety of soldiers, the threat to soldiers from brain damage caused by deformation at the back of the helmet cannot be ignored, so research on reduce blunt post-cranial injury has great significance and value. This study first conducted gunshot experiments, used rifle bullets impact bulletproof plate and different density liner foam to record the incident process and internal response of craniocerebral model. After verifying the accuracy of finite element model through experimental data, optimization model is established based on response surface method to optimize the structure of gradient foam, analyze the cranial strain and energy absorption to select the best density and thickness distribution of each foam layer. Optimization results show that liner foam which designed to have lower density and thicker thickness for impact and brace layers, higher density and thinner thickness for middle layer can significantly improve the energy absorption efficiency. Compared to the 40.65 J of energy absorption before optimization, the optimized gradient foam can absorb 109.3 J of energy, with a 169% increase in the absorption ratio. The skull strain in the craniocerebral model was reduced from 1.260 × 10–2 to 1.034 × 10–2, with a reduction of about 22%. This study provides references for the design and development of protective equipment and plays an important role in ensuring the safety of soldiers in the battlefield environment.
Clinical studies of detecting COVID-19 from exhaled breath with electronic nose
Authors: Kwiatkowski Andrzej , Borys Sebastian , Sikorska Katarzyna , Drozdowska Katarzyna , Smulko Janusz M. 
Published: September 2022

AbstractThe COVID-19 pandemic has attracted numerous research studies because of its impact on society and the economy. The pandemic has led to progress in the development of diagnostic methods, utilizing the polymerase chain reaction (PCR) as the gold standard for coronavirus SARS-CoV-2 detection. Numerous tests can be used at home within 15 min or so but of with lower accuracy than PCR. There is still a need for point-of-care tests available for mass daily screening of large crowds in airports, schools, and stadiums. The same problem exists with fast and continuous monitoring of patients during their medical treatment. The rapid methods can use exhaled breath analysis which is non-invasive and delivers the result quite fast. Electronic nose can detect a cocktail of volatile organic com-pounds (VOCs) induced by virus infection and disturbed metabolism in the human body. In our exploratory studies, we present the results of COVID-19 detection in a local hospital by applying the developed electronic setup utilising commercial VOC gas sensors. We consider the technical problems noticed during the reported studies and affecting the detection results. We believe that our studies help to advance the proposed technique to limit the spread of COVID-19 and similar viral infections.
Hippocampal cells segregate positive and negative engrams
Authors: Shpokayte Monika , McKissick Olivia , Guan Xiaonan , Yuan Bingbing , Rahsepar Bahar , Fernandez Fernando R. , Ruesch Evan , Grella Stephanie L. , White John A. , Liu X. Shawn , Ramirez Steve 
Published: September 2022

AbstractThe hippocampus is involved in processing a variety of mnemonic computations specifically the spatiotemporal components and emotional dimensions of contextual memory. Recent studies have demonstrated cellular heterogeneity along the hippocampal axis. The ventral hippocampus has been shown to be important in the processing of emotion and valence. Here, we combine transgenic and all-virus based activity-dependent tagging strategies to visualize multiple valence-specific engrams in the vHPC and demonstrate two partially segregated cell populations and projections that respond to appetitive and aversive experiences. Next, using RNA sequencing and DNA methylation sequencing approaches, we find that vHPC appetitive and aversive engram cells display different transcriptional programs and DNA methylation landscapes compared to a neutral engram population. Additionally, optogenetic manipulation of tagged cell bodies in vHPC is not sufficient to drive appetitive or aversive behavior in real-time place preference, stimulation of tagged vHPC terminals projecting to the amygdala and nucleus accumbens (NAc), but not the prefrontal cortex (PFC), showed the capacity drive preference and avoidance. These terminals also were able to change their capacity to drive behavior. We conclude that the vHPC contains genetically, cellularly, and behaviorally segregated populations of cells processing appetitive and aversive memory engrams.
„Essen sie einfach, was sie wollen“ ist nicht genug
Welche Informationen zum Thema Ernährung Krebs-Betroffene wirklich
brauchen
Authors: Neubauer Sandra , Blumers Anne , Erickson Nicole 
Published: September 2022

ZusammenfassungKrebspatient:innen wollen gerne aktiv an ihrer Genesung mitwirken. Der Bereich
Ernährung ist dafür ideal. Über die Ernährung
können Patient:innen in jeder Phase der Erkrankung dazu beitragen, die
Gesamtsituation ihres Körpers und damit ihre Therapievoraussetzungen zu
verbessern. Um im Bereich Ernährung selbst aktiv werden zu
können, brauchen die Patient:innen konkrete, wissenschaftlich fundierte
Empfehlungen, die leicht verständlich sind und sich im Alltag gut
umsetzen lassen. Sie müssen verstehen, dass ein bestehender Tumor durch
die Ernährung nicht direkt beeinflusst oder geheilt werden kann. Die
Ernährung während einer Krebserkrankung soll den Körper
mit ausreichend Energie, Eiweiß und Nährstoffen versorgen,
Gewichtsverlust und Mangelernährung vorbeugen, Beschwerden lindern und
die Lebensqualität verbessern. Einfach gesagt, die Kraft erhalten
für den Kampf gegen den Krebs.Seit 2017 bietet die gemeinnützige Informationsplattform
was-essen-bei-krebs.de fundierte Empfehlungen, Alltagshilfen, Rezepte,
Selbsttests und persönliche Begleitung rund um das Thema
Ernährung bei Krebs. Mit ca. 40.000 Besuchern monatlich ist
was-essen-bei-krebs.de inzwischen eine etablierte Anlaufstelle für
Patient*innen, Angehörige und Fachpersonal im deutschsprachigen
Raum. In diesem Artikel geht es darum, welche Informationen und Hilfestellungen
Patient:innen sich wünschen und brauchen.
Phytotherapie in der S3-Leitlinie Komplementärmedizin in der
Behandlung von onkologischen Patient:innen
Authors: Rostock Matthias 
Published: September 2022

ZusammenfassungIm September 2021 ist erstmals eine Leitlinie für
Komplementärmedizin in der Behandlung von onkologischen Patient:innen in
Deutschland publiziert worden. Während andere
komplementärmedizinische Verfahren wie Akupunktur, Akupressur,
Homöopathie und Verfahren der Mind-Body-Medizin wie Meditation,
Mindfulness-based Stress Reduction, Tai-Chi/Qigong und Yoga bei
spezifischen Indikationen zumindest mit einer offenen Empfehlung
(„kann“) eingeordnet wurden, betraf dies in der Phytotherapie
lediglich Zubereitungen aus den Drogen der vier Heilpflanzen Traubensilberkerze,
Ginseng, Ingwer und Mistel. In diesem Artikel wird zum einen der methodologische
Hintergrund für diese Bewertung erörtert. Zum anderen erfolgt
eine Diskussion über einen wissenschaftlich und klinisch angemessenen
Umgang mit der Phytotherapie bei Patient:innen mit Tumorerkrankungen vor dem
Hintergrund dieser neu veröffentlichten Leitlinie.
Tracing the Progression of Sepsis in Critically Ill Children: Clinical Decision Support for Detection of Hematologic Dysfunction
Authors: Bode Louisa , Schamer Sven , Böhnke Julia , Bott Oliver Johannes , Marschollek Michael , Jack Thomas , Wulff Antje ,   ELISE Study Group
Published: September 2022

Abstract
Background One of the major challenges in pediatric intensive care is the detection of life-threatening health conditions under acute time constraints and performance pressure. This includes the assessment of pediatric organ dysfunction (OD) that demands extraordinary clinical expertise and the clinician's ability to derive a decision based on multiple information and data sources. Clinical decision support systems (CDSS) offer a solution to support medical staff in stressful routine work. Simultaneously, detection of OD by using computerized decision support approaches has been scarcely investigated, especially not in pediatrics.
Objectives The aim of the study is to enhance an existing, interoperable, and rule-based CDSS prototype for tracing the progression of sepsis in critically ill children by augmenting it with the capability to detect SIRS/sepsis-associated hematologic OD, and to determine its diagnostic accuracy.
Methods We reproduced an interoperable CDSS approach previously introduced by our working group: (1) a knowledge model was designed by following the commonKADS methodology, (2) routine care data was semantically standardized and harmonized using openEHR as clinical information standard, (3) rules were formulated and implemented in a business rule management system. Data from a prospective diagnostic study, including 168 patients, was used to estimate the diagnostic accuracy of the rule-based CDSS using the clinicians' diagnoses as reference.
Results We successfully enhanced an existing interoperable CDSS concept with the new task of detecting SIRS/sepsis-associated hematologic OD. We modeled openEHR templates, integrated and standardized routine data, developed a rule-based, interoperable model, and demonstrated its accuracy. The CDSS detected hematologic OD with a sensitivity of 0.821 (95% CI: 0.708–0.904) and a specificity of 0.970 (95% CI: 0.942–0.987).
Conclusion We could confirm our approach for designing an interoperable CDSS as reproducible and transferable to other critical diseases. Our findings are of direct practical relevance, as they present one of the first interoperable CDSS modules that detect pediatric SIRS/sepsis-associated hematologic OD.
The Use of Ultrasound Imaging for Upper Extremity Lymphedema after Breast Cancer: A Systematic Review
Authors: Canales-Lachén Elena , Asunsolo Ángel , Manrique Oscar J. , Blázquez Javier , Holguín Purificación , Maldonado Andrés A. 
Published: September 2022

Abstract
Background The aim of this study was to analyze the different applications of ultrasound (US) in upper extremity lymphedema (UEL) after breast cancer.
Methods A systematic review of the literature was performed in line with the PRISMA statement using MEDLINE/PubMed databases from January 1970 to December 2021. Articles describing the application of US in patients with UEL after breast cancer were included. The quality of the study, the level of reproducibility, and the different applications and type of US technique were analyzed.
Results In total, 30 articles with 1,193 patients were included in the final review. Five different applications were found: (1) diagnosis of UEL (14 studies found a direct correlation between lymphedema and morphological and/or functional parameters); (2) staging/severity of UEL (9 studies found a direct correlation between the clinical stage and the soft-tissue stiffness/texture/thickness); (3) therapeutic assessment (3 studies found an improvement in the circulatory status or in the muscle/subcutaneous thickness after conservative treatments); (4) prognosis assessment of UEL (1 study found a correlation between the venous flow and the risk of UEL); and (5) surgical planning (3 studies determined the location of the lymphatic vessel for lymphovenous anastomosis [LVA] surgery).
Conclusion Morphological and functional parameters have been correlated with the diagnosis, stage, therapeutic effect, prognosis of UEL, and surgical planning of LVA.
Acute Mediastinal Bleeding with Pleural Escape: Case Report of a Rare Interventional Complication with Unusual Resolve
Authors: Widodo Wishnu Aditya , Mansjoer Arif , Dilawar Ismail , Kurnia Andri , Ruslim Daniel 
Published: September 2022

AbstractAcute mediastinal bleeding is a very rare complication of cardiac intervention. It is a life-threatening situation when this condition causes acute compression of the mediastinal area. A 59-year-old man was diagnosed with inferior ST-elevation myocardial infarction with ongoing chest pain and underwent an urgent percutaneous coronary intervention procedure. After coronary stent was implanted, patient complained of chest tightness, and suffocation, blood pressure dropped, O2 saturation dropped, and was difficultly intubated. Image acquisition by C-arm showed a large bulging in aortic arch area. Contrast-enhanced computed tomography ruled out aortic dissection, but noted a large mediastinal mass that was radiated to the neck. The bulging was spontaneously regressed, and a large left pleural effusion was developed. Left pleural tapping was performed on day 7, and a total of 1.5-L hemorrhagic fluid was evacuated. In our case, unusual drainage from mediastinal to pleural space has probably save the patient.
Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks
Authors: Marciano Sabina , Ionescu Tudor M. , Saw Ran Sing , Cheong Rachel Y. , Kirik Deniz , Maurer Andreas , Pichler Bernd J. , Herfert Kristina 
Published: September 2022

Receptors, transporters, and ion channels are important targets for therapy development in neurological diseases, but their mechanistic role in pathogenesis is often poorly understood. Gene editing and in vivo imaging approaches will help to identify the molecular and functional role of these targets and the consequence of their regional dysfunction on the whole-brain level. We combine CRISPR-Cas9 gene editing with in vivo positron emission tomography (PET) and functional MRI (fMRI) to investigate the direct link between genes, molecules, and the brain connectome. The extensive knowledge of theSlc18a2gene encoding the vesicular monoamine transporter (VMAT2), involved in the storage and release of dopamine, makes it an excellent target for studying the gene network relationships while structurally preserving neuronal integrity and function. We edited theSlc18a2in the substantia nigra pars compacta of adult rats and used in vivo molecular imaging besides behavioral, histological, and biochemical assessments to characterize the CRISPR-Cas9–mediated VMAT2 knockdown. Simultaneous PET/fMRI was performed to investigate molecular and functional brain alterations. We found that stage-specific adaptations of brain functional connectivity follow the selective impairment of presynaptic dopamine storage and release. Our study reveals that recruiting different brain networks is an early response to the dopaminergic dysfunction preceding neuronal cell loss. Our combinatorial approach is a tool to investigate the impact of specific genes on brain molecular and functional dynamics, which will help to develop tailored therapies for normalizing brain function.
Dual roles of β-arrestin 1 in mediating cell metabolism and proliferation in gastric cancer
Authors: Yu Huan , Wang Man , Zhang Ting , Cao Lihua , Li Zhongwu , Du Yang , Hai Yanru , Gao Xiangyu , Ji Jiafu , Wu Jianmin 
Published: September 2022

β-Arrestin 1 (ARRB1) has been recognized as a multifunctional adaptor protein in the last decade, beyond its original role in desensitizing G protein-coupled receptor signaling. Here, we identify that ARRB1 plays essential roles in mediating gastric cancer (GC) cell metabolism and proliferation, by combining cohort analysis and functional investigation using patient-derived preclinical models. Overexpression of ARRB1 was associated with poor outcome of GC patients and knockdown of ARRB1 impaired cell proliferation both ex vivo and in vivo. Intriguingly, ARRB1 depicted diverse subcellular localizations during a passage of organoid cultures (7 d) to exert dual functions. Further analysis revealed that nuclear ARRB1 binds with transcription factor E2F1 triggering up-regulation of proliferative genes, while cytoplasmic ARRB1 modulates metabolic flux by binding with the pyruvate kinase M2 isoform (PKM2) and hindering PKM2 tetramerization, which reduces pyruvate kinase activity and leads to cellular metabolism shifts from oxidative phosphorylation to aerobic glycolysis. As ARRB1 localization was shown mostly in the cytoplasm in human GC samples, therapeutic potential of the ARRB1–PKM2 axis was tested, and we found tumor proliferation could be attenuated by the PKM2 activator DASA-58, especially in ARRB1highorganoids. Together, the data in our study highlight a spatiotemporally dependent role of ARRB1 in mediating GC cell metabolism and proliferation and implies reactivating PKM2 may be a promising therapeutic strategy in a subset of GC patients.
Nuclear magnetic resonance diffraction with subangstrom precision
Authors: Haas Holger , Tabatabaei Sahand , Rose William , Sahafi Pardis , Piscitelli Michèle , Jordan Andrew , Priyadarsi Pritam , Singh Namanish , Yager Ben , Poole Philip J. , Dalacu Dan , Budakian Raffi 
Published: September 2022

We have combined ultrasensitive force-based spin detection with high-fidelity spin control to achieve NMR diffraction (NMRd) measurement of ~2 million31P spins in a(50 nm)3volume of an indium-phosphide (InP) nanowire. NMRd is a technique originally proposed for studying the structure of periodic arrangements of spins, with complete access to the spectroscopic capabilities of NMR. We describe two experiments that realize NMRd detection with subangstrom precision. In the first experiment, we encode a nanometer-scale spatial modulation of thez-axis magnetization of31P spins and detect the period and position of the modulation with a precision of <0.8 Å. In the second experiment, we demonstrate an interferometric technique, utilizing NMRd, to detect an angstrom-scale displacement of the InP sample with a precision of 0.07 Å. The diffraction-based techniques developed in this work extend the Fourier-encoding capabilities of NMR to the angstrom scale and demonstrate the potential of NMRd as a tool for probing the structure and dynamics of nanocrystalline materials.
What ever happened to thebelles infidèles?
Authors: Buzelin Hélène 
Published: September 2022

AbstractOver the past thirty years, crime fiction, children’s literature, comics and, to a lesser extent, romance novels have received growing attention from translation scholars. Drawing on an analysis of this translation studies literature and interviews conducted with translators working in different publishing sectors, this paper revisits the hypothesis ofClem Robyns (1990), who proposed that non-canonical literary translations are thebelles infidèlesof the twentieth century. In a spirit reflecting the evolution of the discipline, the author examines not only the textual norms, but also the translators’ viewpoint and their role in the publishing process. The questions at the heart of this reflection are the following: to what extent doesadaptation – to use a less value-laden term thanbelle infidèle – (still) constitute the translation norm of non-canonical literatures? How do the actors participating in the translation of these literatures and their involvement in the publishing process differ from those governing the translation of institutional literature? Finally, what can the study of these literatures teach us about translation and some of the key notions and oppositions in contemporary translation theories?