bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Interscalene Brachial Plexus Block with a Single-dose Intra-articular Local Anesthetic on Postoperative Pain
Authors: KOCA Erdinç , ARI Bünyamin 
Published: October 2022

Aim: Postoperative pain management is important because shoulder surgery causes severe pain. In this present study our aim was to analyse the comparison of the influences of ultrasonography-guided interscalene block and perioperative intra-articular local anesthetic injection on postoperative pain in cases who will undergo arthroscopic shoulder procedure.
Material and Method: It was planned as a prospective randomized controlled trial. After the confirmation of the local ethical committee, our cases were randomly divided into two groups and one group (Group ISBPB) was administered general anesthesia after ultrasonography guided interscalene block. In the other group (Group LA), surgical procedure was carried out under general anesthesia and a single dose of intra-articular local anesthetic was administered peroperatively. Postoperative analgesia requirement, time, VAS scores, patient and surgeon satisfaction were registered.
Results: We could not obtain a statistically significance between group LA and group ISBPB groups according to gender, side, comorbidity, additional procedure and age variables in the participants included in the study (p>0.05). A numerically significance was observed between Group LA and Group ISBPB groups in terms of first analgesia requirement and patient satisfaction variables in the participants included in the study (p
A Comparison of Eating Attitudes, Diet Quality, and Nutrition Knowledge in Polycystic Ovary Syndrome
Authors: DAYIOĞLU ULUDAĞ Büşra , CEBİRBAY M. Ali 
Published: October 2022

Aim: The purpose of the study was to compare the eating attitude, diet quality, and nutrition knowledge of adult women in Konya according to with and without Polycystic Ovary Syndrome (PCOS).
Material and Method: The study is designed as a survey and the sample consists of 400 adult women in two groups, 80 of whom were diagnosed with PCOS by a medical doctor and 320 were not. The data were obtained using a face-to-face interview with a five parted questionnaire.
Results: The mean scores of EAT-40 of women with and without PCOS diagnosis were 22.2±1.270 and 18.9±0.538, respectively. Women diagnosed with PCOS were more predisposed to eating behavior disorders (p=0.008). The diet quality of both groups was evaluated as poor. The total nutrition knowledge mean score is found 68.4±0.670. According to the regression model, EAT-40 scores and BMI found differed (p=0.000). A positive correlation between DQI-I scores and BMI (p=0.029) and a relation between DQI-I scores and nutrition knowledge (p=0.000).
Conclusion: The results of the study showed that women with PCOS had more eating behavior disorders, and diet quality was poor in both groups. For this reason, women with PCOS should be made aware of eating, diet quality should be increased, and food attitudes and nutrition knowledge should be provided to maintain a healthier life.
Economic aspects of using new chemotherapy regimens for multidrug and extensively drugresistant tuberculosis
Authors: Kukurika А. V. 
Published: October 2022

Objective: to systematize data on cost-effectiveness evaluation of new multidrug and extensively drug-resistant tuberculosis (MDR/XDR-TB) chemotherapy regimens.Material and methods. An analysis of 19 publications devoted to the economic evaluation of the treatment of active MDR/XDR-TB was carried out. The literature search was performed in the electronic databases PubMed/MEDLINE, Google Scholar, eLibrary for the period from January 2015 to February 2022 inclusively.Results. Economic efficiency was studied in high-, middleand low-income countries. All publications contained calculation of treatment costs, and a third of the studies also estimated additional costs. Bedaquiline, delamanid, and pretomanid regimens were included in treatment alone or compared with a background regimen. The most commonly used economic model was the Markov one. To compare primary outcomes, most studies assessed disabilityand quality-adjusted life years. The overall cost of MDR/XDR-TB treatment varied by country income level. In all cases, bedaquiline-based regimens represented a cost-effective alternative to previous treatment, showed high efficacy in MDR/XDR-TB therapy, and were more cost-effective than delamanid regimens.Conclusion. Cost-effective interventions for active MDR/XDR-TB therapy should include the introduction of new chemotherapy regimens, reduced hospital stays and decentralized treatment, which is especially relevant in countries with high tuberculosis burden.
Economic burden of the novel coronavirus infection: a systematic review
Authors: Timiryanova V. M. , Lakman I. A. , Zagidullin N. Sh. , Gareeva D. F. 
Published: October 2022

Background. The sudden emergence and rapid spread of the novel coronavirus infection (COVID-19) caused tremendous burden on the health care system including the economic one. In this regard, many questions concerning the prioritization of funding for various restrictive and preventive procedures have arisen; also the introduction of various intervention methods for monitoring and timely treatment of post-COVID consequences became an urgent problem. These challenges actualized the development of pharmacoeconomic methods that improve the quality of decisions making in such extreme conditions.Objective: to systematize available studies on the assessment of the global economic burden of the novel coronavirus infection.Material and methods. A feature of the proposed review design was the highlighting of the observed shortcomings and areas in which scientists make additions to the assessment methods taking into account the chronology of the pandemic determining changes in the information field. Therefore, an analysis was made of 80 studies published in 2020–2022 and dedicated to the assessment and forecast of the global economic burden of COVID-19. The main inclusion criteria for the studies was the estimation of COVID-19 global burden. The search was carried out in PubMed/MEDLINE, Web of Science, Scopus, and eLibrary databases. Using a predefined data collection form, two reviewers independently extracted information characterizing the studies.Results. An analysis of the publications showed a fairly wide variety of studies in the field of the COVID-19 burden, including those determined by the difference in observation objects, analysis methods, factors taken into account, etc. Scientists actively use international (73.8%) and national (90%) databases, and surveys (57.5%). Predominantly, the estimates involve the calculation of quality-adjusted life years lost (QALY) (66.3%), 37.6% of the studies are based on the results of constructing scenario models, 28.8% consume algorithms of epidemiological SIR (susceptible, infected, or recovered) models, and 66.3% provide for cost assessment. As part of the estimated economic burden, the loss of productivity (26.3% of publications), the introduction of vaccination (32.5%), comorbidity (25%), post-COVID complications (17.5%) are considered.Conclusion. A significant interest of the world scientific community in assessing the COVID-19 global burden is observed, determined by the search for the most effective study methods. Further investigations in this area should focus on detailing within the estimated economic burden of losses associated with post-COVID-19 complications, including their various combinations, as well as on the analysis of the correlation and mutual compensation of effects from various types of treatment, with a deeper study of indirect losses. The results of this work will be also useful in conducting similar studies, including for determining their design and applying modern mathematical modeling tools.
A Magnitude Estimation Approach and Application to the Yunnan Earthquake Early Warning Network
Authors: Zhang Guo-quan , Li Dan-ning , Gao Yang , Yang Jing-qiong 
Published: October 2022

Abstract
Estimating the magnitude based on P waves is important to issue early messages to the general public for earthquake early warning (EEW) purposes. First, we reviewed part of the magnitude estimation results of the current EEW system deployed in Yunnan and found that the magnitude of the mainshock of the Yangbi earthquake sequence (Ms 6.4, as formally determined by the Yunnan Seismic Network) is severe underestimated by 0.9, whereas a number of small earthquakes are overestimated. Then, we determined the reason for this phenomenon and improved the magnitude estimation precision in Yunnan by introducing the fixed effect regression technique, adopting a flexible time window and deriving the magnitude estimation equation strictly. Finally, we examined the deficiencies of this magnitude estimation approach and demonstrated that it is possible to provide instant and reliable parameters of an earthquake through numerous inexpensive accelerometers on the ground.
The review of the bronchial asthma morbidity in the population of the Russian Federation
Authors: Bystritskaya E. V. , Bilichenko T. N. 
Published: October 2022

According to the World Health Organization (WHO), bronchial asthma (BA) is a major non-communicable disease which affects both adults and children and thereby impacts the economy.The aim. To analyze the bronchial asthma morbidity and follow-up care in Russia in 2019 as compared with 2014.Methods. The official statistical data of the Ministry of Health of Russia and the Federal State Statistics Service (Rosstat) on BA was used. BA was defined as class X J45 – J46 (asthma, asthmatic status) according to the International Classification of Diseases and Health-Related Problems, the 10th revision of 1 989 (ICD-10).Results. The BA morbidity was 961.6 in 2014 and 1085.0 (+11.4%; p < 0,001) per 100 thousand of the total population in 2019 (1,592,596 people). BA accounted for 2.7% of all respiratory diseases (RD) morbidity. The BA morbidity in 2014 and 2019 were higher than average in 4 federal districts (FD) with the maximum rate in the Siberian FD (1,185.5 and 1,507.1 per 100 thousand of the total population, respectively). In 2019, the BA morbidity decreased among children aged 0 – 14 years, did not change among children aged 15 – 17 years and increased among the adults. In 2019, the highest rates among children aged 15 – 17 years were registered in the North-Western FD (2,943.7 per 100 thousand in the corresponding age group). 87.1% of BA patients received follow-up care. In 2019, 32.3% of all people with respiratory diseases (944.3 per 100 thousand of the total population) were under follow-up care. The highest number of BA patients under follow-up care was recorded in the Siberian FD (1,328.3 per 100 thousand of the total population), the lowest number – in the North Caucasian FD (288.3).Conclusion. There was an increase of BA morbidity from 2014 to 2019 with the highest numbers reported in the total population of Siberian FD and the lowest – in adolescents aged 15 – 17 years in North-Western FD. The quality of medical care correlated with high coverage with follow-up care.
Experience of using benralizumab in the treatment of patients with severe asthma in the clinical practice of pulmonologists in Saint-Petersburg
Authors: Sereda V. P. , Svirido D. A. , Komarov M. V. , Mironova Zhanna A , Nyoma M. A. 
Published: October 2022

The accumulation of clinical experience in the use of biologic therapy in patients with severe bronchial asthma (SBA) in real-world clinical practice with the possible identification of additional, previously undescribed clinical outcomes is of practical interest.The aim. To present the results of an observational study of using benralizumab in SBA in real clinical practice of pulmonologists in Saint-Petersburg.Methods. We present the results of more than 1 year of follow-up of 18 patients with eosinophilic SBA (12 women, 6 men, age from 28 to 74, average age 55.0 ± 11.9 years). The patients received benralizumab in addition to standard treatment. Clinical, laboratory, and functional examination of the patients were performed, the frequency of exacerbations and additional clinical effects were assessed. Results. It has been shown that the inclusion of benralizumab in complex therapy resulted in a significant improvement in disease control, improved bronchial conduction, a significant decrease in blood eosinophilia, and a reduction in the number of exacerbations. A clinical example is given that indicates a stabilizing effect of this therapy on the course of recurrent nasal polyposis with an initially aggressive course (intracranial polyp growth).Conclusion. The possibility of significant improvement in the control of SBA with the use of biological therapy has been confirmed in real clinical practice. At the same time, data have been obtained that will allow expanding the indications for the use of benralizumab in the future.
Blood plasma cathepsin S in severe bronchial asthma
Authors: Kraposhina A. Yu. , Sobko E. A. , Demko I. V. , Katser A. B. , Kazmerchuk O. V. , Abramov Yu. I. , Eydemiller N. S. 
Published: October 2022

The aim. To determine the level of cathepsin S and to identify its possible relationships with clinical, functional and laboratory indicators in patients with severe bronchial asthma.Methods. 114 patients with severe bronchial asthma were examined. 96 women (84.2%) and 18 (15.8%) men were divided into 2 groups: allergic and non-allergic severe bronchial asthma. The external respiration function was assessed with whole-body plethysmography (“Erich Jaeger”, Germany). The plasma concentration of cytokines IL-4, IL-5, IL-13, periostin, cathepsin S, TGF-β was estimated with ELISA (“eBioscience”, USA).Results. Fixed obstruction is reported in 48% and 50% of cases of allergic and non-allergic severe asthma, respectively. Peripheral blood eosinophilia occurs in 41.5% of cases with allergic and in 25% of cases with non-allergic asthma. IL-5, IL-13, and cathepsin S levels were increased in both groups. An increase in IL-4 and TGF-β levels was revealed in non-allergic asthma. Periostin levels were increased in patients with allergic asthma as compared with the control and the second group. Positive correlation between cathepsin S and concentration of IL-4, IL-5 was established in both groups. We identified weak positive correlation between cathepsin S levels and clinical symptoms of the disease, such as frequency of SABA use and asphyxiation attacks, only in the allergic asthma group. A positive correlation between cathepsin S and TGF-β was established in both groups.Conclusion. A positive correlation between serum cathepsin S and TGF-β was established in both allergic and non-allergic severe bronchial asthma. The found moderate relationship may indirectly indicate the involvement of cathepsin S in airway remodeling processes regardless of the disease type.
Taste dyfunction in obese type 2 diabetic individuals
Authors: Hasan Afshan Zainab , Preethi B L  , Kalra Pramila , Kumar M Arun 
Published: October 2022

Obesity is a well-known risk factor for many diseases. It is also known to enhance complications of many diseases eg. Type 2 Diabetes mellitus (T2DM). This study was done to assess the gustatory functions in obese T2DM individuals. This study was done to assess the gustatory functions in obese T2DM subjects and compare the same with lean T2DM individuals. A comparative study with a sample size of 40 was conducted. Patients aged 25 to 50 years with T2DM &#60; 5 years duration and HBA1C ≤ 7 were divided into 2 groups, Group I- with normal weight (BMI of 18.5 to &#60;25) and Group II with grade 1 obesity (BMI of 30 to &#60; 35). Triple Drop Test was done to evaluate gustatory functions. Scoring from “5” to “1” was done on the identification of different concentrations of tastants. Taste scores for sweet, salty, sour, and bitter tastants were lesser in obese diabetics as compared to the lean T2DM subjects. This was statistically significant (p &#60; 0.05) Conclusion: Taste impairment is observed in obese diabetic subjects. This could be an indication of early central diabetic neuropathy. Hypogeusia may cause an increased preference for sweet-tasting or salty foods thus imposing greater health risks, increasing obesity, and negatively affecting the quality of life.
Variations in renal arteries and pelvicalyceal system: A case report
Authors: Hottigoudar Suma Yekapppa , Akhil Jakkula , Stephen Priyanka Clementina , Sontakke Yogesh Ashok 
Published: October 2022

To describe a complex case of anomalous kidneys involving right early division of renal artery, left accessory renal artery, bilateral upper polar arteries and bilateral extrarenal calyces. This is a very rare case documented having these four anomalies together.The variations were observed during routine anatomical dissection in a male cadaver at department of anatomy, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Pondicherry, IndiaDuring dissection, multiple anatomical variations involving the structures at the hilum of right kidney were found. Right kidney showed early division of renal artery (RRA) 1.4 cm close to aorta. Left kidney showed accessory renal artery (LARA) 5 mm above origin of main renal artery (LRA), running obliquely entering the hilum. Two polar arteries were seen entering upper pole on right kidney as well as left kidney (RUPA1, RUPA2, LUPA1, LUPA2). Extrarenal calyces were observed to be present in both the kidneys, two on the right and three on the left.The variations observed are of importance as multiple anomalies are present in a single cadaver. They are of significance during surgical procedures like renal transplantation, aortic surgeries and in radiological interpretation.
Respiratory Distress Due to Giant Pulmonary Hydatid Cyst
Authors: Ershadi Reza 
Published: October 2022

Pulmonary echinococcosis most frequently occurs in the right and both lower lobes. Children are more likely to develop pulmonary rather than hepatic echinococcal cysts. Some evidence suggests that echinococcal cysts develop more rapidly in the lungs of children than those of adults, which may explain the more common appearance of pulmonary cysts in children. Younger patients have larger cysts owing to their greater tissue elasticity. Large pulmonary hydatid cysts are critical because they pose a higher risk of rupture. Herein, we present an eight-year-old girl presented with severe respiratory distress due to giant hydatid cyst of right lung with shift of the mediastinum at left. The lesion displaced the trachea at left. The patient was successfully treated by parenchymal-saving operation. In conclusion, Giant hydatid lung cysts represent a distinct clinical entity most frequently encountered in children and adolescents with more serious symptoms. Although non-complicated giant hydatid cysts have a good prognosis regardless of their size and can be safely treated by parenchyma-preserving surgery.
An Incidental Detection of a Cryptic Complex Chromosome Rearrangement Found During NGS Based PGT-SR: A Case Report
Authors: Özer Leyla , Aktuna Suleyman , Unsal Evrim , Baltaci Aysun , Baltaci Volkan 
Published: October 2022

Background: Complex chromosome rearrangements (CCRs) involve more than 2 chromosomal breakpoints and cause the exchanges of chromosomal segments between two or more chromosomes. The carriers of CCRs have normal phenotypes, but they have a higher risk of reproductive failure.
Case Presentation: This paper presents a couple with a history of two affected children, one spontaneous abortion, three in vitro fertilization (IVF) failures, and one healthy boy who were referred to our laboratory for preimplantation genetic testing (PGT). The wife had been evaluated as a carrier of 46,XX,t (2;6)(p21;p25); therefore, four IVF treatment cycles supported with PGT for this translocation had been performed in different IVF centers until the couple consulted our laboratory. Only one of these four IVF attempts had resulted in a healthy boy and this IVF study had been performed with fluorescence in situ hybridization (FISH)-based preimplantation genetic testing for structural chromosomal rearrangements (PGT-SR). The fifth IVF study with next-generation sequencing (NGS)-based PGT was performed by our laboratory and no healthy embryo was found in evaluated 6 embryos. During our NGS-based PGT, the cryptic involvement of 12p was firstly detected. FISH with chromosome 2,6, and 12 specific probes revealed that the mother was a carrier of a balanced 3-way translocation of 46,XX,t(2;6;12)(p21;p25;p13).
Conclusion: NGS based PGT-SR method is an accurate method for detecting the copy number variations and is helpful to find out the cryptic CCRs.
How do learning organisation and reward system affect lecturers’ innovative work behaviour?
Authors: Sulistiasih S. , Widodo Widodo 
Published: October 2022

Innovative work behaviour (IWB) is essential for the survival of individuals and organisations. Therefore, this research examines IWB based on learning organisation, reward systems, and job involvement perspectives. It also proves job involvement’s role in mediating learning organisation and reward systems on IWB. A quantitative approach was adopted with a causal design, and questionnaires were administered to 230 lecturers of private universities in Indonesia to collect data. The result of path analysis showed that learning organisation, reward system, and job involvement significantly affects IWB. Job involvement also mediates the relationship between the learning organisation and rewards system with IWB. Therefore, a new model that learning organisation and reward system affects IWB mediated by job involvement is confirmed. IWB can be improved through learning organisation and reward system with the support of job involvement.

Keywords: learning organisation, reward system, job involvement, innovative work behaviour, lecturer.
Kemampuan Basic Knolwledge Guru Sekolah Dasar Peserta Program Pendidikan Profesi Guru
Authors: Wardani Rizki Putri , Fitriyah Chumi Zahroul 
Published: October 2022

The Teacher Certification Program was an educational form that aimed at increasingthe professionalism of teachers. The aim of this research was to describe before and after basic knowledge of primary teachers that has been already joining in Teacher Certification Program. Basic knowledge is knowledge about understanding lesson plans which is suitable with basic competence, lesson theory, until research plan after teaching to support teacher professionalism. The research method was a quantitative description. Technique this research was an interview with a primary teacher that has been already joining the teacher certification program. Data analysis using a percentage of basic knowledge before and after primary teacher. Data result has been shown basic knowledge primary teacher is increased from arranging lesson plan for doing research and reflection in the learning process

Pendidikan Profesional Guru merupakan bentuk pendidikan yang ditujukan bagi guru untuk meningkatkan keprofesionalan guru. Tujuan dari penelitian ini untuk mendeskripsikan kemampuan dasar atau Basic Knowledge guru Sekolah Dasar sebelum dan sesudah mengikuti Pendidikan Profesional Guru (PPG). Kemampuan dasar atau basic knowledge merupakan kemampuan yang meliputi pemahaman rencana pembelajaran yang sesuai kompetensi dasar, pemahaman teori belajar, hingga penelitian setelah pembelajaran untuk mendukung profesional guru. Metode dalam penelitian ini adalah deskriptif kuantitatif. Teknik wawancara dilakukan dalam penelitian ini dengan subjek guru sekolah dasar yang telah megikuti PPG. Analisis data menggunakan hasil presentasi kemampuan guru sebelum dan sesudah mengikuti PPG. Hasil penelitian menunjukkan bahwa kemampuan Basic Knowledge guru Sekolah Dasar meningkat, dimulai dari kemampuan melakukan perencanaan sampai melakukan penelitian perbaikan dalam pembelajaran.