bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous Functional Magnetic Resonance and Optoacoustic Imaging of Brain‐Wide Sensory Responses in Mice
Authors: Chen Zhenyue , Gezginer Irmak , Augath Mark‐Aurel , Liu Yu‐Hang , Ni Ruiqing , Deán‐Ben Xosé Luís , Razansky Daniel 
Published: November 2022

AbstractFunctional magnetic resonance imaging (fMRI) has massively contributed to the understanding of mammalian brain function. However, the origin and interpretation of the blood oxygen level‐dependent (BOLD) signals retrieved by fMRI remain highly disputed. This article reports on the development of a fully hybridized system enabling concurrent functional magnetic resonance optoacoustic tomography (MROT) measurements of stimulus‐evoked brain‐wide sensory responses in mice. The highly complementary angiographic and soft tissue contrasts of both modalities along with simultaneous multi‐parametric readings of stimulus‐evoked hemodynamic responses are leveraged in order to establish unequivocal links between the various counteracting physiological and metabolic processes in the brain. The results indicate that the BOLD signals are highly correlated, both spatially and temporally, with the total hemoglobin readings resolved with volumetric multi‐spectral optoacoustic tomography. Furthermore, the differential oxygenated and deoxygenated hemoglobin optoacoustic readings exhibit superior sensitivity as compared to the BOLD signals when detecting stimulus‐evoked hemodynamic responses. The fully hybridized MROT approach greatly expands the neuroimaging toolset to comprehensively study neurovascular and neurometabolic coupling mechanisms and related diseases.
Evaluating genital skin color as a putative sexual signal in wild saddleback (Leontocebus weddelli) and emperor (Saguinus imperator) tamarins
Authors: Moreira Lais A. A. , Watsa Mrinalini , Erkenswick Gideon , Higham James P. , Melin Amanda D. 
Published: November 2022

AbstractCoevolution between signalers and receivers has played a significant role in the diversity of animal signals and sensory systems. Platyrrhines (monkeys in the Americas) exhibit a remarkable color vision polymorphism that may have been selected by both natural and sexual selection, but sociosexual color signaling among platyrrhines has received almost no attention. Here, we study the color of reproductive skin among different reproductive classes in free‐ranging female saddleback (Leontocebus weddelli) and emperor (Saguinus imperator) tamarins, modeling color spaces, and contrasts for the different visual systems. We find that the chromatic saturation and luminance of genital color vary between reproductive classes in saddleback tamarins. Chromatic contrast between the vulva and belly is lower in the parous females (PFs) relative to adult but not currently breeding females, while achromatic contrast is higher in PFs in saddleback tamarins relative to nonparous females. However, in emperor tamarins, genital color (saturation, hue, and luminance) does not vary between reproductive classes. Overall, genital skin color variation is present in tamarins and may play a role in sexual signaling. Nevertheless, the patterns are inconsistent between species, suggesting interspecific variation. Future studies should integrate the perceiver's behavioral responses and the physical and social signaling environments into comprehensive studies of communication as well as consider the role and interaction between multiple sensory modalities.
DystoniaBoTXNet: Novel Neural Network Biomarker of Botulinum Toxin Efficacy in Isolated Dystonia
Authors: Yao Dongren , O'Flynn Lena C. , Simonyan Kristina 
Published: November 2022

ObjectiveIsolated dystonia is characterized by abnormal, often painful, postures and repetitive movements due to sustained or intermittent involuntary muscle contractions. Botulinum toxin (BoTX) injections into the affected muscles are the first line of therapy. However, there are no objective predictive markers or standardized tests of BoTX efficacy that can be utilized for appropriate candidate selection prior to treatment initiation.MethodsWe developed a deep learning algorithm, DystoniaBoTXNet, which uses a 3D convolutional neural network architecture and raw structural brain magnetic resonance images (MRIs) to automatically discover and test a neural network biomarker of BoTX efficacy in 284 patients with 4 different forms of focal dystonia, including laryngeal dystonia, blepharospasm, cervical dystonia, and writer's cramp.ResultsDystoniaBoTXNet identified clusters in superior parietal lobule, inferior and middle frontal gyri, middle orbital gyrus, inferior temporal gyrus, corpus callosum, inferior fronto‐occipital fasciculus, and anterior thalamic radiation as components of the treatment biomarker. These regions are known to contribute to both dystonia pathophysiology across a broad clinical spectrum of disorder and the central effects of botulinum toxin treatment. Based on its biomarker, DystoniaBoTXNet achieved an overall accuracy of 96.3%, with 100% sensitivity and 86.1% specificity, in predicting BoTX efficacy in patients with isolated dystonia. The algorithmic decision was computed in 19.2 seconds per case.InterpretationDystoniaBoTXNet and its treatment biomarker have a high translational potential as an objective, accurate, generalizable, fast, and cost‐effective algorithmic platform for enhancing clinical decision making for BoTX treatment in patients with isolated dystonia. ANN NEUROL 2023;93:460–471
A Foldable Aqueous Zn‐Ion Battery with Gear‐Structured Composite as Freestanding Cathode
Authors: Liu Jinyun , Zhu Yajun , Han Tianli , Zhang Huigang , Hu Chaoquan , Niu Junjie 
Published: November 2022

AbstractA foldable battery with high flexibility provides great potential in various wearable electronic devices for health and fitness tracking, chronic disease management, performance monitoring, navigation tracking, and portable gears for soldiers. We report a highly flexible, self‐healing Zn‐ion battery with a free‐standing cathode that is composed of a 3D gear‐like NH4V4O10@C composite on carbon paper. The battery retained a capacity of up to 102.4 mAh g−1even after being folded 60 times with a high angle of 180°. An aqueous hydrogel consisting polyvinyl alcohol, glycerin and Zn(CF3SO3)2was used as electrolyte, which showed as high as 580 % tensile strain under a loading weight of 78 N. The battery exhibited a better capacity retention of over 100 mAh g−1and Coulombic efficiency of over 99.8 % after cutting and twisting to 90°, thereby indicating a great self‐healing performance. The gear‐like geometry greatly improved the volume accommodation due to the increased interval space between the blades and the outward configuration. Meanwhile the Zn2+ionic conductivity was improved by rapid re‐binding of many existing hydroxy groups from the electrolyte and the enhanced contact surface area and diffusion route from the cathode material. The highly flexible, safe aqueous Zn‐ion battery opens a practical way to power various carry‐on electronics under mechanical agitation.
Regioselective Electrochemical Hydroalkylations of [60]Fullerene‐Fused Furochromenone
Authors: Yin Zheng‐Chun , Niu Chuang , Li Mingjie , Liu Wen‐Rui , Wang Guan‐Wu 
Published: November 2022

Comprehensive SummaryRegioselective electrochemical hydroalkylations of [60]fullerene‐fused furochromenone with alky halides under different acidic conditions unexpectedly afford three types of tetra‐functionalized [60]fullerene derivatives in high yields. When acetic acid is used as the proton source, two 1,2,3,4‐adducts with retained or rearranged five‐membered heterocycle are obtained as major and minor products, respectively. While trifluoroacetic acid is employed as the proton source, 1,2,3,16‐adducts and 1,2,3,4‐adducts, both with the five‐membered heterocycle rearranged from [6,6]‐junction to [5,6]‐junction, are generated. Intriguingly, the obtained 1,2,3,16‐adducts can be transformed into 1,2,3,4‐adducts accompanied by rearrangement of the fused five‐membered heterocycle from [5,6]‐junction to [6,6]‐junction. These products have been characterized by spectroscopic data and single‐crystal X‐ray analysis. Moreover, the two 1,2,3,4‐adducts with the heterocycle fused to [5,6]‐junction or [6,6]‐junction show diagnostic UV‐vis spectra, which may be useful for the identification of these two types of 1,2,3,4‐adducts in the future. A plausible reaction mechanism has been proposed to elucidate the formation of hydroalkylation products in the presence of different acids.
Theoretical and Experimental Investigation on 1,2,3‐Benzotriazole 4‐Hydroxybenzoic Acid (BTHBA) Single Crystals for Third‐Order Nonlinear Optical (NLO) Applications
Authors: Sahaya Infant Lasalle B. , Manikandan A. , Senthil Pandian Muthu , Ramasamy P. 
Published: November 2022

Abstract1,2,3‐Benzotriazole 4‐hydroxybenzoic acid (BTHBA) is synthesized and single crystals of dimension 20 mm × 9 mm × 5 mm are grown from methanol solvent by conventional solution growth method. Single crystal X‐ray diffraction data show that BTHBA belongs to the orthorhombic crystallographic system with non‐centrosymmetric space group Pna21. The grown organic nonlinear optical (NLO) crystal is subjected to various characterizations like powder X‐ray diffraction, UV–vis–NIR, photoconductivity, thermogravimetric differential thermal analysis (TG‐DTA), and chemical etching analysis. Optimization of the molecular structure, highest occupied molecular orbital–lowest unoccupied molecular orbital energy, natural bond orbital analysis, molecular geometry, and molecular electrostatic potential are investigated using Gaussian 09w software. The laser damage threshold value of BTHBA crystal is estimated to be 13.4 GW cm−2 using a Nd:YAG laser. The third‐order NLO susceptibility of BTHBA crystal reveals relatively high values of about 8.95 × 10−9 esu when compared with that of standard potassium dihydrogen phosphate (KDP) (8.3 × 10−14 esu). Hence it can be effectively employed for various optoelectronic and photonic applications.
Longitudinal multidiversity pattern and the environmental drivers of riparian bird communities along submontane rivers of Changbai Mountains, China
Authors: Xu Wenyu , Gong Ye , Wang Lin , Yao Jiyuan , Wang Haitao 
Published: November 2022

AbstractRiparian zones are biodiversity hotspots in montane ecosystems and are of critical conservation concern. However, studies on longitudinal diversity patterns and environmental drivers have been restricted to aquatic fauna, while the animals that rely on both river and riparian resources have been of much less concern. Here, we examined the multifaceted diversity distribution of riparian birds along longitudinal gradients and analyzed the importance of environmental factors in shaping these patterns in the Changbai Mountains. Hump‐shaped relationships between elevation and taxonomic, phylogenetic, and functional diversity, as well as with the conservation value index, were evident along each of the classic submontane rivers. Forest cover, vegetation height variation, and land cover patches positively affected the taxonomic diversity indices. In addition to the species richness, fluvial geomorphology variables (river sinuosity and gravel bar) were significantly related to the phylogenetic diversity. However, there was no statistical evidence for a relationship between functional diversity and the environmental variables examined. This study emphasized the necessity of including multiple diversity measures beyond taxonomic diversity and demonstrated the importance of both terrestrial and aquatic components in shaping the multifaceted biodiversity pattern of riparian organisms living in riparian zones. The results suggested that conservation priority should be given to both rivers and banks in the middle reaches and that riparian birds could be good candidate indicators of environmental change in the submontane river‐forest ecotone.
3D‐printed β‐TCP/S53P4 bioactive glass scaffolds coated with tea tree oil: Coating optimization, in vitro bioactivity and antibacterial properties
Authors: Alves Ana Paula Nogueira , Arango‐Ospina Marcela , Oliveira Rodrigo Luiz Moraes Saldanha , Ferreira Igor Maia , de Moraes Elisângela Guzi , Hartmann Malte , de Oliveira Antônio Pedro Novaes , Boccaccini Aldo Roberto , de Sousa Trichês Eliandra 
Published: November 2022

AbstractBone infection treatment is a significant challenge for the orthopedic field. 3D printing is a promising technology to produce scaffolds with customized architecture, able to stimulate and support bone growth. β‐TCP and S53P4 bioactive glass (BG) are well‐known biomaterials for scaffold manufacturing. However, a multifunctional scaffold, able to inhibit microbial proliferation at the defect site, is of increasing interest to avoid infection recurrence. Tea tree oil (TTO) has aroused interest as an antimicrobial agent to minimize the use of antibiotics. Therefore, combining the regenerative potential of a bioceramic with TTO's antimicrobial properties could result in a scaffold capable of stimulating tissue growth and treating infections. In this context, this study aimed to produce and characterize 3D‐printed β‐TCP/S53P4 BG scaffolds coated with TTO. Scaffolds morphological and chemical characterizations were carried out through XDR, SEM, and FTIR analysis. β‐TCP/S53P4 BG scaffolds showed a compressive strength of ~2 MPa and 53 ± 2% of porosity. The scaffolds were coated by two different procedures, using an ethanol/TTO (EtOH/TTO) and a gelatin/TTO (Gel/TTO) solution with 5, 10, and 15% (v/v) TTO. The addition of TTO decreased MG‐63 cell viability for both coating groups, but the Gel/TTO group showed higher cell viability. The antibacterial activity of the coated scaffolds was evaluated against S. aureus and higher inhibition of colony formation was found for Gel/TTO group. Therefore, the coating with Gel/TTO was effective in terms of antibacterial activity and cell viability. Such Gel/TTO coated β‐TCP/S53P4 BG scaffolds are proposed for antibacterial bone tissue engineering.
Harold Garfinkel and Edward Rose in the early years of ethnomethodology
Authors: Mlynář Jakub 
Published: November 2022

AbstractThis article documents the beginning of the intellectual companionship between the founder of ethnomethodology, Harold Garfinkel, and Edward Rose, who is most often associated with his program of “ethno‐inquiries.” I present results from archival research focusing on the contacts and collaborations between Rose and Garfinkel in the years 1955–1965. First, I describe the review process for Rose and Felton's paper, submitted to the American Sociological Review in 1955, which Garfinkel reviewed and after Rose's rebuttal recommended for publication. The paper induced Garfinkel to write an extensive commentary that has remained unpublished. Second, I discuss the 1958 New Mexico conference sponsored by the Air Force, which was an opportunity for Rose and Garfinkel to work together on topics related to common‐sense knowledge and scientific knowledge. Third, I give an overview of the ethnomethodological conferences in 1962 and 1963, supported by an Air Force grant written collaboratively by Rose and Garfinkel. Here I focus primarily on Rose's research on “small languages,” which stimulated many discussions among the early ethnomethodologists. Rose's work and exchanges with Garfinkel demonstrate the former's affinity for miniaturization as a research approach and search for ways to empiricize topics of sociological theory in locally observable settings.
Determining Invasion Depth in Superficial Pharyngeal Carcinoma by Transoral Ultrasonography
Authors: Yumii Kouhei , Ueda Tsutomu , Urabe Yuji , Fukuhara Motomitsu , Chikuie Nobuyuki , Taruya Takayuki , Kono Takashi , Hamamoto Takao , Hattori Minoru , Takumida Masaya , Ishino Takashi , Takeno Sachio 
Published: November 2022

ObjectivesTo examine the clinical usefulness of transoral ultrasonography (US) in determining the invasion depth of superficial pharyngeal carcinoma (SPC). Determining the invasion depth of SPC is crucial for transoral surgery including determining treatment strategy. This study aimed to examine the usefulness of transoral US in determining the invasion depth of SPC.MethodsForty‐six patients with 51 lesions who underwent both magnifying endoscopy with narrow‐band imaging (ME‐NBI) and transoral US were included. The primary outcomes were the sensitivity, specificity, positive (PPV), and negative predictive values (NPV) of ME‐NBI and transoral US findings for pathological tumor depth in SPCs.ResultsThe accuracy (82.4%), sensitivity (85.2%), PPV (82.1%), and NPV (82.6%) rates of US for subepithelial propria (SEP) were higher than those of ME‐NBI and macroscopic classification, indicating that transoral US is superior to ME‐NBI in determining the invasion depth. All cases where the SEP was clearly invaded (SEP deep) could be diagnosed as SEP by transoral US.ConclusionsTransoral US may be useful in determining the invasion depth of SPCs.Level of Evidence3 Laryngoscope, 133:2192–2197, 2023
Risk prediction models for head and neck cancer: A rapid review
Authors: Smith Craig D. L. , McMahon Alex D. , Ross Alastair , Inman Gareth J. , Conway David I. 
Published: November 2022

AbstractBackgroundCancer risk assessment models are used to support prevention and early detection. However, few models have been developed for head and neck cancer (HNC).MethodsA rapid review of Embase and MEDLINE identified n = 3045 articles. Following dual screening, n = 14 studies were included. Quality appraisal using the PROBAST (risk of bias) instrument was conducted, and a narrative synthesis was performed to identify the best performing models in terms of risk factors and designs.ResultsSix of the 14 models were assessed as “high” quality. Of these, three had high predictive performance achieving area under curve values over 0.8 (0.87–0.89). The common features of these models were their inclusion of predictors carefully tailored to the target population/anatomical subsite and development with external validation.ConclusionsSome existing models do possess the potential to identify and stratify those at risk of HNC but there is scope for improvement.
Barriers to medication adherence in children, adolescents, and young adults prescribed anticoagulation
Authors: Todd Kevin , Luchtman‐Jones Lori , Blackmore Anne , Hennessey Carrie , McGrady Meghan E. 
Published: November 2022

AbstractPediatric and adolescent and young adult (AYA) thromboembolism is treated with anticoagulation, but little is known about adherence. The aims of this study were to describe barriers to adherence among children and AYAs (ages 0–25 years) prescribed anticoagulants and to explore the relationship between barriers and self‐reported adherence. Nearly 75% of patients and caregivers reported barriers, and a larger number of barriers was associated with missing at least one dose in the past month per both patient (rpb = 0.48, p = .01) and caregiver (rpb = 0.52, p = .01) report. Limitations, clinical implications, and future directions are discussed.
Utility of salivary mycophenolic acid concentration monitoring: Modeling and Monte Carlo validation approach
Authors: Catić‐Đorđević Aleksandra , Stefanović Nikola , Pavlović Ivan , Pavlović Dragana , Živanović Slavoljub , Kundalić Ana , Veličković‐Radovanović Radmila , Mitić Branka 
Published: November 2022

AbstractThe results of the previous studies demonstrated an association between mycophenolic acid (MPA) exposure, serum albumin level (ALB), and adverse effects in kidney transplant patients. The aim was the identification of mathematical correlation and association between both, total and unbound MPA concentration in relation to ALB, body mass (BM), age and estimated glomerular filtration rate (eGFR) in stable kidney transplant recipients. Furthermore, investigation was conducted with the aim to clarify the role of salivary concentration (CSAL) of MPA in adverse effect profile. In order to analyze the association between total and salivary concentration of MPA in relation to ALB, BM, age and eGFR, a least squares method for determining the correlation between these parameters was performed. In addition, derived mathematical model based on experimental data can also be performed and simulated through the Monte Carlo (MC) approach. Adverse effects were grouped according to the nature of symptoms and scored by a previously published validated system. Numerically calculated values of CSAL from the models [CSAL = f(ALB, BM, age, eGFR, CP) = a00 + a10*(ALB, BM, age, eGFR) + a01*CP] were then compared with those from validation set of patients, where the best fitting model was for ALB [CSAL = 54.96–1.64*ALB +13.4*CP]. Adverse effects estimation showed the difference in esthetic score, positively correlated with CSAL in the lower ALB group (145.41 ± 219.02 vs. 354.08 ± 262.19; with statistical significance p = .014) and almost significant for gastrointestinal score (167.69 ± 174.79 vs. 347.55 ± 320.95; p = .247). The study showed that CSAL MPA may contribute to management of adverse effects, but these findings require confirmation of clinical utility.
Nimbolide attenuates complete Freund's adjuvant induced arthritis through expression regulation of toll‐like receptors signaling pathway
Authors: Israr Maham , Naseem Nadia , Akhtar Tasleem , Aftab Usman , Zafar Muhammad Shoaib , Faheem Muhammad Asif , Shahzad Muhammad 
Published: November 2022

AbstractNimbolide is an active constituent of Azadirachta indica and is known for its anti‐inflammatory, anti‐oxidant, immune‐modulatory, and anti‐cancer effects. Few studies suggest that nimbolide treatment influences the responses to rheumatoid arthritis, but the underlying molecular mechanisms involved are not yet well established. Therefore, the present study was designed to determine the effect of nimbolide on expression regulation of toll‐like receptors to attenuate rheumatoid arthritis. The rheumatoid arthritis model was established by injecting complete Freund's adjuvant (CFA) intra‐dermally into the sub‐plantar region of the left hind paw of rats. Nimbolide (20 mg/kg) and piroxicam (10 mg/kg) were given to arthritic rats. Rats treated with nimbolide showed a significant reduction in inflammatory cells, rheumatoid factor, ESR, and improved the body weight. The results indicated that nimbolide possesses the capacity to attenuate rheumatoid arthritis by downregulating toll‐like receptors, IL‐17, IL‐23, HSP70, and IFN‐γ expression levels. Nimbolide treatment showed significant reduction in the severity of inflammation and destruction of joints and showed comparable effects to piroxicam, which is a standard non‐steroidal anti‐inflammatory drug used for the treatment of rheumatoid arthritis. It can be concluded that nimbolide can be considered as a potential candidate for therapeutic targeting of the toll‐like receptors pathway in rheumatoid arthritis.
Air‐Stable Radical Organic Cages as Cascade Nanozymes for Enhanced Catalysis
Authors: Yang Xiao‐Dong , Zhang Ya‐Jun , Zhou Jun‐Hao , Liu Ling , Sun Jian‐Ke 
Published: November 2022

AbstractThe pursuit of single‐assembled molecular cage reactors for complex tandem reactions is a long‐standing target in biomimetic catalysis but still a grand challenge. Herein, nanozyme‐like organic cages are reported by engineering air‐stable radicals into the skeleton upon photoinduced electron transfer. The generation of radicals is accompanied by single‐crystal structural transformation and exhibits superior stability over six months in air. Impressively, the radicals throughout the cage skeleton can mimic the peroxidase of natural enzymes to decompose H2O2 into OH· and facilitate oxidation reactions. Furthermore, an integrated catalyst by encapsulating Au clusters (glucose oxidase mimics) into the cage has been developed, in which the dual active sites (Au cluster and radical) are spatially isolated and can work as cascade nanozymes to prominently promote the enzyme‐like tandem reaction via a substrate channeling effect.