bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does new bone formation vary in different sites within the same maxillary sinus after lateral augmentation? A prospective histomorphometric study
Authors: Stacchi Claudio , Rapani Antonio , Lombardi Teresa , Bernardello Fabio , Nicolin Vanessa , Berton Federico 
Published: January 2022

AbstractObjectiveThe aim of this study was to evaluate histomorphometric outcomes of lateral maxillary sinus augmentation in different areas of the same cavity and to correlate results to bucco‐palatal sinus width (SW) and residual bone height (RBH).Material and MethodsPatients needing maxillary sinus floor elevation (RBH <5 mm) to insert two nonadjacent implants were treated with lateral augmentation using a composite graft. Six months later, two bone‐core biopsies (mesial/distal) were retrieved in implant insertion sites. SW and RBH were measured on cone beam computed tomography, and correlations between histomorphometric and anatomical parameters were evaluated by multivariate linear regression analysis.ResultsTwenty patients underwent sinus augmentation, and eighteen were included in the final analysis (two dropouts for membrane perforation). Mean newly formed mineralized tissue percentage (%NFMT) after 6 months in mesial and distal sites was 17.5 ± 4.7 and 11.6 ± 4.7, respectively (p = .0004). Multivariate linear regression showed a strong negative correlation between SW and %NFMT (β coefficient=−.774, p < .0001) and no correlation between RBH and %NFMT (β coefficient =−.038, p = .825).ConclusionsThe present study confirms that %NFMT after lateral sinus augmentation occurs at different rates in different anatomical areas of the same maxillary sinus, showing a strong negative correlation with SW, whereas no influence of RBH was observed. Clinicians should regard SW as a guide for graft selection and to decide duration of the healing period. Researchers should consider SW as a predictor variable, when comparing regenerative outcomes of different biomaterials by using maxillary sinus as an experimental model.
Labor supply response to overpayment notifications: Evidence from Social Security Disability Insurance
Authors: Anand Priyanka , Hoffman Denise , Jones John T. , Lukashanets Siarhei 
Published: January 2022

AbstractWe use administrative data to provide evidence that notification of work‐related overpayment debt reduces subsequent work activity by Social Security Disability Insurance beneficiaries. We exploit randomness in the timing of the overpayment debt notification by comparing beneficiary work activity before and after notification. Our results show that the share of overpaid beneficiaries engaging in substantial work activity declined by 8% over the 2‐month period following an overpayment notification, which reduced to 4% after accounting for the ongoing declining trend in work activity. This evidence that overpayment debt notification discourages work highlights the need for policies to curtail overpayments.
Handgrip exercise induces sex‐specific mean arterial pressure and oxygenation responses but similar performance fatigability
Authors: Keller Joshua L. , Kennedy Katie G. , Hill Ethan C. , Fleming Sydnie R. , Colquhoun Ryan J. , Schwarz Neil A. 
Published: January 2022

AbstractWomen exhibit an attenuated exercise pressor reflex (EPR) when compared to men. The influence of sex‐specific mechanisms related to the EPR and performance fatigability remain to be fully elucidated. The purpose was to determine the impact of oxygenation and metabolic efficiency on sex‐specific performance fatigability and increases in mean arterial pressure (MAP) resulting from a fatiguing isometric handgrip (IHG). Twenty‐four adults volunteered to perform an IHG at 25% at maximal voluntary isometric contractions (MVICs). Pre‐ and posttest MVICs were conducted to quantify performance fatigability. MAP was collected at 3 timepoints. A near‐infrared spectroscopy device was attached to the forearm to derive the following signals: oxy[haem], deoxy[haem], total[haem], and diff[haem]. These values were normalized and examined across time in 5% segments of time‐to‐task‐failure. Metabolic efficiency was defined as the ratio force:deoxy[haem]. During the IHG, there was a decline in oxy[haem] for the men (b = −0.075), whereas the women demonstrated an increase (b = 0.117). For the men, the diff[haem] tracked the mean oxy[haem] response, but there was no change for the women. The men exhibited greater declines in metabolic efficiency, yet there were no sex differences in PF (46.6 ± 9.7% vs. 45.5 ± 14.2%). For relative MAP, the men (24.5 ± 15.1%) exhibited a greater (p = .03) increase than the women (11.0 ± 17.6%). These results indicated the EPR was more prominent for the men, perhaps due to differences in mechanical stimuli and a lack of ability to maintain metabolic efficiency. However, these physiological differences did not induce a sex difference in performance fatigability.
Responsiveness to left‐prefrontal tDCS varies according to arousal levels
Authors: Esposito Marco , Ferrari Clarissa , Fracassi Claudia , Miniussi Carlo , Brignani Debora 
Published: January 2022

AbstractOver the past two decades, the postulated modulatory effects of transcranial direct current stimulation (tDCS) on the human brain have been extensively investigated. However, recent concerns on reliability of tDCS effects have been raised, principally due to reduced replicability and to interindividual variability in response to tDCS. These inconsistencies are likely due to the interplay between the level of induced cortical excitability and unaccounted structural and state‐dependent functional factors. On these grounds, we aimed at verifying whether the behavioural effects induced by a common tDCS montage (F3‐rSOA) were influenced by the participants' arousal levels, as part of a broader mechanism of state‐dependency. Pupillary dynamics were recorded during an auditory oddball task while applying either a sham or real tDCS. The tDCS effects were evaluated as a function of subjective and physiological arousal predictors (STAI‐Y State scores and pre‐stimulus pupil size, respectively). We showed that prefrontal tDCS hindered task learning effects on response speed such that performance improvement occurred during sham, but not real stimulation. Moreover, both subjective and physiological arousal predictors significantly explained performance during real tDCS, with interaction effects showing performance improvement only with moderate arousal levels; likewise, pupil response was affected by real tDCS according to the ongoing levels of arousal, with reduced dilation during higher arousal trials. These findings highlight the potential role of arousal in shaping the neuromodulatory outcome, thus emphasizing a more careful interpretation of null or negative results while also encouraging more individually tailored tDCS applications based on arousal levels, especially in clinical populations.
Human movements do not look the same in a tilted world: Gravitational constraints influence the perception of biological motion
Authors: Pavlidou Anastasia , Lange Joachim , Ferrè Elisa Raffaella 
Published: January 2022

AbstractWe investigated whether gravitational constraints influence the interaction of visual, proprioceptive and vestibular cues for Biological Motion Perception (BMP). Participants were asked to distinguish between plausible and random point‐light movements, while passively placed in either an upright or a tilted body orientation. Manipulating the body orientation with respect to gravity leads to different gravitational signals transmitted by the visual, proprioceptive, and vestibular systems. Participants were overall faster in distinguishing plausible point‐light movements than random movements. Critically, response times for biologically plausible point‐light movements — but not for random movements — were significantly prolonged in the tilted body orientation. Our results suggest that BMP depends not only on the spatial–temporal cues embedded in point‐light movements but also rely on the congruency between current gravitational signals detected by the sensory systems and our previous knowledge of terrestrial gravity.Statement of RelevanceAs humankind is preparing for a new space age, understanding how gravity influences behaviour and cognition has never been more pressing. All living organisms have evolved to survive in a terrestrial gravitational field. Although we cannot consciously feel gravity, it has an impact in our life: it affects how we move and interact with the external environment. The sensory signals from the vestibular system are continuously combined with visual and proprioceptive cues to help us in maintaining a stable representation of the world. Here we placed participants in a tilted body orientation and were able to determine that a conflict between prior gravitational knowledge and what was actively sensed about gravity affected human Biological Movement Perception. Humans suffer changes in perception under non‐terrestrial gravity conditions that may potentially compromise performance during space exploration.
Pricing and inventory carryover strategy considering cost learning effect and strategic consumers
Authors: Wei Qian , Zhang Jianxiong , Zhu Guowei 
Published: January 2022

AbstractAnticipating the markdown in the future price due to the cost reduction of the firm, more and more consumers tend to delay their purchasing to the later period. Incorporating the strategic behavior of consumers, this paper establishes a two‐period production and selling model under dynamic pricing strategy and price commitment strategy respectively, with considering stochastic learning effect in which the firm may or may not have the inventory carryover option. The results show that the firm may hold inventory under dynamic pricing while no inventory is kept under price commitment. Additionally, consumers' patience level enhances the benefit of inventory carryover. Furthermore, for the firm with relatively high farsighted level and low inventory holding cost, the dynamic pricing equipped with inventory carryover outperforms the price commitment strategy. Finally, numerical examples are conducted to analyze the impacts of important parameters on the firm's choice of pricing strategies.
Online 3D gamification for teaching a human resource development course
Authors: Chung Chih‐Hung , Lin You Yin 
Published: January 2022

AbstractBackgroundMost students have exhibited low motivation to engage in traditional learning methods. Additionally, students have difficulty concentrating on the course content, being easily distracted by their smartphones.ObjectivesTherefore, we adopted an online 3D gamification problem‐based learning (PBL) model to motivate students and improve their learning satisfaction and achievement on a human resource development course.MethodsWe followed the ADDIE instructional design model and used four essential topics to formulate our teaching activities in the three‐dimensional sandbox game, Creativerse. Moreover, this paper conducted an explorative study by using ANCOVA and partial least squares structural equation modelling to test student learning achievement and analyse the relationships between components such as performance expectancy (PE), effort expectancy (EE), social influence (SI), and facilitating conditions (FC).Results and conclusionsOur online 3D gamification PBL model enhanced learning achievement on the courses; moreover, FC is the most critical factor influencing learning satisfaction. This study provided suggestions for operating an online 3D gamification PBL teaching approach.ImplicationsThe current paper also explained how students' learning satisfaction relates to these significant factors. Moreover, this study's findings will help instructional designers and instructors to develop online 3D gamification learning environments.
A dermocosmetic formulation containing Vichy volcanic mineralizing water,Vitreoscilla filiformisextract, niacinamide, hyaluronic acid, and vitamin E regenerates and repairs acutely stressed skin
Authors: Gueniche A. , Valois A. , Salomao Calixto L. , Sanchez Hevia O. , Labatut F. , Kerob D. , Nielsen M. 
Published: January 2022

AbstractThe exposome has an impact on skin from life‐long exposure. Acute short‐term exposure to exposome stressors can also alter skin functions such as skin physical barrier and immune defenses, leading to skin dryness, sensitivity, flares of inflammatory skin conditions, or viral reactivations. Probiotics are defined as live microorganisms, which, when administered in adequate amounts, confer a health benefit on the host. An extract produced by lysingVitreoscilla filiformis(VfeV) cultured in Vichy volcanic mineralizing water (VVMW) has properties of probiotic fractions. In this review, we presentin vivoandex vivostudies with a dermocosmetic formulation containing 80% VVMW, 5% VfeV, 4% niacinamide (vitamin B3), 0.4% hyaluronic acid, and 0.2% vitamin E (M89PF) to evaluate the clinical efficacy in preventing and repairing stressed skin. Skin barrier benefits of M89PF were shown in studies after the skin was exposed to sudden thermal changes, after skin irritation by tape stripping, and in sleep‐deprived women. M89PF significantly accelerated skin renewal compared to untreated skin. Skin antioxidant defense activity of M89PF was shown after exposure to stress from UVA plus cigarette smoke aggression. Skin microbiome recovery after acute stress from a harsh cleanser was significantly better in M89PF‐treated skin compared to bare skin. Clinical benefits of M89PF on correcting clinical signs of stressed skin were shown in both Caucasian and Asian women exposed to a stressful lifestyle and various external (pollution, tobacco smoking, solar radiation) and internal (poor sleep, stressful work, unbalanced diet, and alcohol consumption) exposome factors. M89PF also showed depigmenting properties on dark spots in Asian women. Further clinical studies are now warranted to evaluate the efficacy of M89PF as adjuvant care to prevent and repair skin barrier disruption and reinforce skin defenses in skin exposed to acute stresses.
Differences in colour preference among pollen beetle species (Coleoptera: Nitidulidae)
Authors: Vuts József , Szarukán István , Marczali Zsolt , Csonka Éva Bálintné , Szilágyi Arnold , Imrei Zoltán , Nagy Antal , Tóth Miklós 
Published: January 2022

AbstractPollen beetles (Coleoptera: Nitidulidae) are major pests of oilseed rape and other crucifers. Efficient and timely management of these pests can greatly be improved by effective monitoring of their spatial and temporal distribution. In field trials in Hungary, we have discovered striking differences in colour responsiveness among pollen beetle species: Brassicogethes aeneus F. 1775 (earlier Meligethes aeneus) and B. viridescens F. 1775 responded most strongly to fluorescent yellow traps, whereas B. coracinus Sturm 1845, Fabogethes nigrescens Sturm 1845 and Meligethes atratus Olivier 1790 were most attracted to blue or white traps. Differences in the spring flight period were also recorded, with B. aeneus and B. viridescens flying ca. 1 month earlier than the other three species. Further tests established that funnel traps having both fluorescent yellow and blue colour cues are the most efficient in attracting a wide range of pollen beetle species. On the other hand, fluorescent yellow traps can be used to detect and monitor B. aeneus specifically.
Inactivation of vegetative cells, germinated spores, and dormant spores of Bacillus atrophaeus by pulsed electric field with fixed energy input
Authors: Wu Wen Jie , Chang Jinhui 
Published: January 2022

AbstractIncreasing the electric energy input during pulsed electric field (PEF) treatment is a straightforward technique to boost the efficiency of microbial inactivation. However, drawbacks such as electrode corrosion, arc formation, and high cost are also involved. This study aims to investigate the impact of medium conductivity (), electric field strength (), and the number of pulses () on the inactivation of vegetative cells, germinated spores, and dormant spores of Bacillus atrophaeus with fixed energy input. Our results indicated that (1) vegetative cells were susceptible to PEF treatment, and the relative importance of , , and was ; (2) germinated spores were more resistant to PEF treatment than vegetative cells, and the relative importance of , , and was ; and (3) similar to the thermal resistance property, dormant spores were also highly resistant to PEF treatment and were not significantly inactivated in our experiment setting. It is concluded that the degree of PEF resistance of cell at different physiological states may be related to its structure and size. This study added to the body of knowledge on selecting PEF treatment settings and gave insight into the scaling up of PEF applications in the food processing industry.Practical ApplicationsIn the food processing industry, eliminating contaminants such as bacterial spores is essential, and PEF processing is a common nonthermal technique. While the traditional method of increasing the electric energy input to increase microbial inactivation efficiency is beneficial, it is not cost‐effective. The results of this investigation demonstrated that decreasing spore resistance through germination followed by parameter‐optimized PEF treatments is a practical method for improving pasteurization efficiency. This novel technique might be used in the food sector.
In vitro assays for the functional characterization of (psychedelic) substances at the serotonin receptor 5‐HT2AR
Authors: Pottie Eline , Stove Christophe P. 
Published: January 2022

AbstractSerotonergic psychedelics are substances that induce alterations in mood, perception, and thought, and have the activation of serotonin (5‐HT) 2A receptors (5‐HT2ARs) as a main pharmacological mechanism. Besides their appearance on the (illicit) drug market, e.g. as new psychoactive substances, their potential therapeutic application is increasingly explored. This group of substances demonstrates a broad structural variety, leading to insufficiently described structure‐activity relationships, hence illustrating the need for better functional characterization. This review therefore elaborates on the in vitro molecular techniques that have been used the most abundantly for the characterization of (psychedelic) 5‐HT2AR agonists. More specifically, this review covers assays to monitor the canonical G protein signaling pathway (e.g. measuring G protein recruitment/activation, inositol phosphate accumulation, or Ca2+ mobilization), assays to monitor non‐canonical G protein signaling (such as arachidonic acid release), assays to monitor β‐arrestin recruitment or signaling, and assays to monitor receptor conformational changes. In particular, focus lies on the mechanism behind the techniques, and the specific advantages and challenges that are associated with these. Additionally, several variables are discussed that one should consider when attempting to compare functional outcomes from different studies, both linked to the specific assay mechanism and linked to its specific execution, as these may heavily impact the assay outcome.
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The altered osteocytic expression of connexin 43 and sclerostin in human cadaveric donors with alcoholic liver cirrhosis: Potential treatment targets
Authors: Jadzic Jelena , Milovanovic Petar D. , Cvetkovic Danica , Zivkovic Vladimir , Nikolic Slobodan , Tomanovic Nada , Djuric Marija P. , Djonic Danijela 
Published: January 2022

AbstractPrevious studies suggested that osteocyte lacunar network disruption could play a role in the complex pathophysiology of bone changes in aging and disease. Considering that particular research interest is lacking, we aimed to assess alcoholic liver cirrhosis (ALC)–induced changes in osteocyte lacunar network and bone marrow adiposity. Immunohistochemistry was conducted to assess changes in the micro‐morphology of osteocyte lacunar network and bone marrow adiposity, and expression of connexin 43 and sclerostin in vertebral and femoral samples collected from 40 cadaveric men (age range between 44 and 70 years) divided into ALC group (n = 20) and control group (n = 20). Furthermore, the assessment of the potential association between bone changes and the severity of the hepatic disorder (given by Knodell's pathohistologic scoring) was conducted. Our data revealed fewer connexin 43‐positive osteocytes per vertebral and femoral bone area (p < 0.01), suggesting defective signal transduction among osteocytes in ALC individuals. Moreover, we found an ALC‐induced increase in the number of adipocytes in the vertebral bone marrow (p = 0.038). Considering significant associations between the severity of liver tissue disturbances and impaired functionality of osteocyte lacunar network (Pearson's correlation analyses, p < 0.05), we may assume that timely treatment of the liver disease may delay bone impairment. ALC induced an increase in osteocytic sclerostin expression (p < 0.001), suggesting its role in mediating low bone formation among ALC individuals. Hence, medicaments targeting low bone formation may be beneficial to attenuate the bone changes among ALC patients. However, future clinical studies are required to verify the therapeutic utility of these findings.
Piperine, an active ingredient of white pepper, suppresses the growth of multidrug-resistant toxigenic Vibrio cholerae and other pathogenic bacteria
Authors: Manjunath G.B. , Awasthi S.P. , Zahid M.S.H. , Hatanaka N. , Hinenoya A. , Iwaoka E. , Aoki S. , Ramamurthy T. , Yamasaki S. 
Published: January 2022

Abstract
Emergence and rapid spread of multidrug-resistant (MDR) bacteria including Vibrio cholerae are a global public health issue. Much attention has been paid to natural compounds, such as spices and herbs to find novel antimicrobial compounds as they are considered to be cheaper alternatives to develop as a drug. Here, we show that methanol extract of white pepper could inhibit the growth of V. cholerae O1 El Tor variant, responsible for the recent outbreaks/epidemics. Furthermore, we demonstrate for the first time that piperine, the major component of white pepper, showed a dose-dependent bactericidal effect on V. cholerae growth irrespective of their biotypes and serogroups in the presence of 200 and 300 µg ml−1 of piperine, respectively. Piperine also inhibited the growth of MDR strains of Pseudomonas aeruginosa, Escherichia coli isolated from poultry and enterohemorrhagic/enteroaggregative E. coli O104 in the presence of 200 µg ml−1. Interestingly, we did not observe any significant inhibitory effect of piperine on E. coli strains isolated from healthy person even up to 200 µg ml−1. Our data suggest that piperine could be a novel antimicrobial agent in therapeutic and preventive applications against infections caused by pathogenic bacteria including MDR strains.