bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation Into Explainable Recommender System as a Digital Tool for Enticing Customers
Authors: Ene Ugochukwu M. , Bakpo F. S 
Published: November 2022

Abstract
Economic melt-down and increased cost of operations have made Financial Institutions rely more on digital platforms to acquire customers. Financial Institutions must sell more products and services through digital platforms for customer acquisition. However, the right and personalized products have to be suggested in a manner that will entice customers. There is, therefore, the need for financial institutions to deploy explainable recommender systems. This paper investigated Explainable Recommender System (ERS) in the finance domain in two aspects: an investigation into existing and recent methods of enticing customers leveraging on explainable recommendations is presented, then a systematic review of published articles from 2018 to date in the finance domain. Based on this investigation, there was a need to find criteria for designing an ERS and its performance evaluation for efficient use. Despite the increasing research on ERSs, researchers should give more attention to evaluating these explanations for optimum performance.
Conditional Deletion of Neurexin-2 Alters Neuronal Network Activity in Hippocampal Circuitries and Leads to Spontaneous Seizures
Authors: Chen Lulu , Haile Mulatwa , Khoja Sheraz , de Carvalho Gregory , Hunt Robert 
Published: November 2022

Abstract
Neurexins (Nrxns) have been extensively studied for their role in synapse organization and have been linked to many neuropsychiatric disorders, including autism spectrum disorder (ASD), and epilepsy. However, no studies have provided direct evidence that Nrxns may be the key regulator in the shared pathogenesis of these conditions largely due to complexities among Nrxns and their non-canonical functions in different synapses. Recent studies identified NRXN2 mutations in ASD and epilepsy, but little is known about Nrxn2’s role in a circuit-specific manner. Here, we report that conditional deletion of Nrxn2 from the hippocampus and cortex (Nrxn2 cKO) results in behavioral abnormalities, including reduced social preference and increased nestlet shredding behavior. Electrophysiological recordings identified an overall increase in hippocampal CA3◊CA1 network activity in Nrxn2 cKO mice. Using intracranial electroencephalogram recordings, we observed unprovoked spontaneous reoccurring electrographic and behavioral seizures in Nrxn2 cKO mice. This study provides the first evidence that conditional deletion of Nrxn2 induces increased network activity that manifests into spontaneous recurrent seizures and behavioral impairments.
Targeting mTOR to overcome resistance to hormone and CDK4/6 inhibitors in ER-positive breast cancer models.
Authors: Rodriguez María Jimena , Perrone María Cecilia , Riggio Marina , Palafox Marta , Salinas Valeria , Elia Andrés , Salgueiro Natali , Werbach Andrea , Marks María Paula , Kauffman Marcelo A. , Vellón Luciano , Serra Violeta , Novaro Virginia 
Published: November 2022

Abstract
Resistance to therapy remains a major obstacle in cancer management. Although treatment with hormone and CDK4/6 inhibitors is successful in luminal breast cancer, resistance to these treatments is frequent, highlighting the need for novel therapeutic strategies to delay disease progression and improve patient survival. Here, we assessed the mechanisms of acquired resistance using T47D and MCF-7 tamoxifen- and palbociclib-resistant cell-line variants in culture and as xenografts, and patient-derived cells (PDCs) obtained from sensitive or resistant patient-derived xenografts (PDXs). In these, we analyzed the effect of specific kinase inhibitors on survival, signaling and cellular aggressiveness. We found that mTOR inhibition is more effective than PI3K inhibition in overcoming resistance, irrespective of PIK3CA mutation status, by decreasing cell proliferation and tumor growth, as well as reducing cell migration and stemness. Moreover, a combination of mTOR and CDK4/6 inhibitors may prevent pathway reactivation downstream of PI3K, interfering with the survival of resistant cells and consequent tumor escape. In conclusion, we highlight the benefits of incorporating mTOR inhibitors into the current therapy in ER + breast cancer. This alternative therapeutic strategy not only enhances the antitumor response but may also prevent pathway reactivation, delaying the emergence of resistance and tumor recurrence.
Possibility of surgical field contamination by the patient’s exhaled air: evaluation using a carbon dioxide imaging camera and particle counter
Authors: Morioka Masakazu , Takamura Yoshihiro , Miyazaki Hideki T , Gozawa Makoto , Yamada Yutaka , Komori Ryohei , Tanaka Kengo , Inatani Masaru 
Published: November 2022

Abstract
The coronavirus disease (COVID-19) pandemic has led to a dramatic increase in facemask use. Consequently, it has been reported that exhaled airflow toward the eyes can cause the dispersal of bacteria into the eyes, potentially increasing the incidence of postoperative endophthalmitis. In addition to wearing a facemask, gaps between the surgical drape and skin can also direct exhaled airflow toward the eyes. Here, we aimed to examine how the risk of contamination varies depending on the state of the drapes. We used a carbon dioxide imaging camera to visualize changes in exhaled airflow under different drape conditions and a particle counter to evaluate changes in the number of particles around the eye. The results revealed airflow present around the eye and a significant increase in the number of particles when the nasal side of the drape was detached from the skin. However, when a metal rod called “rihika” was used to create space above the body, the airflow and number of particles significantly reduced. Thus, if drape coverage becomes incomplete during surgery, exhaled airflow toward the eye may contaminate the surgical field. On hanging up the drape, airflow can escape in the direction of the body, potentially preventing contamination.
Disrupted Gray Matter Structural Networks between Active and Inactive Phases of Thyroid-Associated Ophthalmopathy
Authors: Luo Lihua , Wen Hongwei , Gao Lixin , Li Dongmei 
Published: November 2022

Abstract
Patients with thyroid-associated opthalmopathy (TAO) reportedly exhibit widespread morphological abnormalities in attention and default mode network (DMN) areas, but alterations in coordinated patterns of brain structural networks underlying TAO are still poorly understood. This study aims to investigate the disruptions in gray matter (GM) structural networks between TAO patients in active and inactive phases. We constructed subject-wise structural networks based on GM volumetric features for 37 active and 35 inactive TAO patients, and 23 healthy controls. Graph theory analysis was conducted to assess the alterations of global and regional network topological properties for TAO patients and their correlation with clinical characteristics. Compared with inactive TAO patients and controls, active TAO patients showed significantly decreased global/local efficiency, and significant altered nodal betweenness centrality (BC) in the visual, attention, DMN and sensorimotor areas. Intriguingly, the BC of left lingual gyrus was significantly negatively correlated with bilateral intraocular pressure, and medial superior/opercular inferior frontal gyrus was significantly correlated with anxiety and depression parameters. Our results suggest that TAO patients at different clinical stages have segregated disruptions in GM network topology, which may due to the visual function and psychological changes. These findings may provide new insights into the neurobiological mechanisms of TAO.
Long-term effect of Padua-Clinical Decision Support on thromboprophylaxis guideline adherence: a prospective cohort study
Authors: Jaspers Tessa , Woestenberg Sandra , Berg Roy van den , Maat Barbara , Khorsand Nakisa , Meijer Karina , Bemt Patricia van den 
Published: November 2022

Abstract
Background: Prescription of Low Molecular Weight Heparins according to the thromboprophylaxis guideline reduces the venous thromboembolism (VTE) incidence in non-surgical hospitalised patients with 80%. To increase guideline adherence, we previously implemented a Clinical Decision Support (CDS) rule based on the Padua score (hereafter: Padua-CDS) in our hospital.
Aim: To determine the effect of the Padua-CDS on thromboprophylaxis guideline adherence two years after implementation (T2), compared to pre-implementation (T0) and immediately after implementation (T1).
Methods: We performed a prospective cohort study in non-surgical patients and compared to previous measurements before and after implementation. Guideline adherence was assessed by calculating the Padua prediction and Improve bleeding score for each patient. Logistic regression analysis was used to analyse the results.
Results: 85 patients were included in T2, the same number of patients previously collected in T0 and T1. Guideline adherence was 81.2%, compared to 49.4% in T0 (OR 4.42, 95%CI 2.21-8.81) and 82.4% in T1 (OR 0.92; 95%CI 0.42-2.01). Guideline adherence in patients with a high VTE risk without bleeding risk was 90.7%, compared to 45.5% in T0 and 84.3% in T1.
Conclusion: Thromboprophylaxis guideline adherence was still significantly increased two years after implementation of the Padua-CDS, demonstrating a sustained effect.
Evaluation of the sodium concentration in the groundwater of the Aquifer Systems of the State of Rio Grande do Sul, Brazil
Authors: Jeske Tailana Bubolz , Reginato Pedro Antonio Roehe 
Published: November 2022

Abstract
Sodium in drinking water is not a health concern for most people, but may be an issue for someone with hypertension, congestive heart failure or on a sodium-restricted diet. This work evaluated sodium concentration data in wells of the main aquifer systems in the state of Rio Grande do Sul (RS) according to the potability standard established by Ordinance No. 888 of 2021 of the Brazilian Ministry of Health. Furthermore, an analysis of sodium concentrations in relation to to the recommendation of the U.S. EPA and other countries on sodium concentration in drinking water less than 20 mg/L for individuals on a sodium-restricted diet (500 mg/day). The human health risk of sodium was assessed by calculating the non-carcinogenic hazard quotient from the US EPA Human Health Risk Assessment. In all, 4,687 hydrogeochemical data from tubular wells that capture water in the Permian Aquitards (AP), Crystalline Basement Aquifer System (SAEC), Guarani Aquifer System (SAG), Coastal Quaternary Aquifer System (SAQC), Palermo - Rio Bonito Aquifer System (SAPRB) and Serra Geral Aquifer System (SASG). More than 100 wells exceeded the maximum allowable amount of sodium in water from Ordinance No. 888 of 2021 of the Brazilian Ministry of Health. All aquifer systems have more than 30% of wells with sodium values above the U.S. EPA recommendation on sodium concentration in drinking water less than 20 mg/L for individuals on a sodium-restricted diet (500 mg/day). Ten wells in RS showed indications of non-carcinogenic risk.
Self-injurious Behavior in Adolescence and Child Abuse: Exploratory Study in a City of the State of Rio De Janeiro, Brazil
Authors: Júnior Antônio Augusto Pinto , de Lima Claudia Henshel , Cassepp-Borges Vicente 
Published: November 2022

Abstract
This article discusses the results of a research on the characteristics of self-injury of adolescents in a city in the interior of the State of Rio de Janeiro, Brazil. The study was carried out with a sample of 50 subjects of both genders, aged between 10 and 16 years, denounced for the practice of self-mutilation by public schools. Interviews were conducted with the participants and their guardians, obtaining data on the characterization, motivation for the practice of self-injury, sociodemographic profile and applicable referrals made. Data analysis was performed by categorizing the interviews with a simple and relative frequency survey. Most participants were female (80.0%), with an average 12.8 years of age, living in monoparental homes (36.0%) exposed to domestic violence (32.3%) and/or child abuse condition (23.1%). The most common behavior was to cause self-injury using a sharp object (76.4%), mainly affecting arms, hands or wrists (72.0%), with such behavior lasting an average period of 10.9 months. In 40% of cases, parents or family members identified self-injury, but most participants (52.0%) were not referred for specialized treatment. It is concluded that, by knowing this type of self-harm, the design of effective prevention measures and assistance actions can be structured.
Limited value of Platelet-related markers in diagnosing periprosthetic joint infection
Authors: song zhenyu , Huang Jincheng , Wang Dong-hui , Wang Qingkai , Feng Jiawei , Cao Qianqian , Chen Xiao , Dai Zhipeng , Gao Zongyan , Jin Yi 
Published: November 2022

Abstract
Objective
To evaluate the diagnostic values of serum platelet count (PC), mean platelet volume ratio (MPV), platelet count to mean platelet volume ratio (PVR), platelet to lymphocyte ratio (PLR), platelet to neutrophil ratio (PNR), and PC/AGR in the diagnosis of periprosthetic joint infection.
Methods
The medical records were retrospectively analyzed of the 158 patients who had undergone hip or knee revisions from January 2018 to January 2021. Of them, 79 cases were diagnosed with PJI and 79 with aseptic loosening (AL). PJI was defined using the Musculoskeletal Infection Society criteria. The plasma levels of C-reactive protein (CRP), the erythrocyte sedimentation rate (ESR), the serum platelet count (PC), mean platelet volume ratio (MPV), platelet count to mean platelet volume ratio (PVR), platelet to lymphocyte ratio (PLR), platelet to neutrophil ratio (PNR), and PC/AGR in the 2 groups were recorded and analyzed. The receiver operating characteristic curve was used to calculate the sensitivity and specificity of each indicator. The diagnostic value for each indicator was calculated according to the area under the curve (AUC).
Results
The PC, PVR, PLR, and PC/AGR levels in the PJI group were significantly higher than those in the AL group (P < .001). The area under the curve of PC/AGR was 0.802, which was slightly lower than that of CRP (0.826) and ESR (0.846). ROC analysis for PC/AGR revealed a cut-off value at 160.63, which provided 84.81% sensitivity and 65.82% specificity for periprosthetic joint infections. The area under the curve of PLR and PC was 0.738 and 0.702. The area under the curve values for PVR, PNR, and MPV were 0.672, 0.553, and 0.544, respectively.
Conclusions
The results of this study suggest that PC, PLR, and PC/AGR values do not offer significant advantages over ESR or CRP values when employed for the diagnosis of PJI. PVR, PNR, and MPV were not reliable in the diagnosis of PJI.
Combination of intracardiac echocardiography and contact force sensing for left ventricular papillary muscle arrhythmias
Authors: Chen Tongshuai , chang lujie , Rong Bing , Zhang Kai , Fan Guanqi , Kong Jing , Ling Mingying , Kong Qingyu , MBBS Kellina Maduray , Zhao Cuifen , Zhong Jingquan 
Published: November 2022

Abstract
Objectives
Catheter ablation of ventricular arrhythmias (VAs) arising from the left ventricular (LV) papillary muscles (PM) is challenging. This study sought to address whether combination of intracardiac echocardiography (ICE) and contact force sensing (CFS) can improve acute and long-term ablation outcomes of left ventricular papillary muscle arrhythmias.
Methods and Results
From May 2015 to August 2022, a total thirty-three patients underwent catheter ablation for LV PM arrhythmias: VAs was located in anterolateral PM in 11, posteromedial PM in 22. Combination of intracardiac echocardiography (ICE) and contact force sensing (CFS) was used in 21 of the 33 procedures. The mean 6.93±4.91 lesions were used per patient and were comparable between the CFS/ICE and No ICE/CFS (4.90±2.23 vs. 10.17±5.89; P=0.011).The mean CF achieved in ICE/CFS group were 7.52±3.31g. Less X-ray time were used in combination group (CFS/ICE: 165.67±47.80 S vs. No ICE/CFS: 365.00±183.73 S; P<0.001). Acute success rate was 100% for ICE/CFS group (n=22) and 66.67% for No ICE/CFS group (n=8). VAs recurrence at 11.21±7.21 months follow-up was 14.2% for ICE/CFS group and 50.00% for No ICE/CFS group (P=0.04). No severe complications occurred in all patients.
Conclusion
Combination of intracardiac echocardiography (ICE) and contact force sensing (CFS) can provide precise geometries of cardiac endo cavitary structures and accurate contact information of catheter during ablation, which improved acute and long-term ablation outcomes. Routine adoption of this strategy should be considered to improve outcomes of LV PM VAs ablation.
Sr-Doped Zinc Phosphate Ceramic Nanoparticles for Bone Regeneration
Authors: huang shenghui , Liu Hanzhong , Li Jiachun , Chen Yingqi , Zhang Wei , Qian Junyu , Hu Yanqing , Wu Liang , Zhang Dongfeng , Yu Fei , Zeng Hui , Wan Junming 
Published: November 2022

Abstract
Background:Synthetic bioceramic repair materials have a broad application prospect in bone defect repair because of their excellent bone conductivity and bone induction.Znic Phosphate ceramic particles are commonly used as bone repair material, but there are still problems such as insufficient osteogenesis and potential biological toxicity.Strontium (Sr) has the function of enhancing bone strength. Even in a wide range of ions concentration, they still have a positive impact on osteogenic differentiation.we made a novel type of Sr doped Znic Phosphate ceramic nanoparticles to explore its role in bone regeneration.
Methods:Bioactive nanoparticles with Zn and Sr and phosphate (Zn2Sr(PO4)2) were prepared through high temperature solid state method. The characterization analysis for Zn2Sr(PO4)2 nanoparticles was confirmed by TEM observation, EDS mapping ,FTIR, XRD, and XPS .The concentration of released Zn2+,Sr2+ and PO43- was measured by ICP. In vitro,the toxic effect and osteogenic capacity of Zn2Sr(PO4)2 to MC3T3-E1 cells was measured.In vivo ,the ability to promote new bone formation of nanoparticles was tested in rat criticalsized supracondylar femur defect models.
Results: In vitro degradation result revealed that the bioactive Zn2+,Sr2+ and PO43- ions were released from nanoparticles in a sustained and stable manner in PBS at 25 oC up to 4 weeks. In vitro osteogenic promotive result showed that the 1/8-1/2 Zn2Sr(PO4)2 nanoparticles cell culture medium extraction,which was at a relatively low concentration, showed superior ability in promoting MC3T3-E1 cell proliferation, osteogenic differentiation, and biomineralization compared to other diluted extract groups and control groups. Finally, 2mg-8mg Zn2Sr(PO4)2 nanoparticles promoted more new bone formation when implanted in the critical sized femoral bone defect (3 mm in diameter) in the rat.
Conclusion:The data suggest that the fabricated Zn2Sr(PO4)2 nanoparticles could act as an attractive candidate for bone regeneration.Zn and Sr play a synergistic role in this process,which avoids potential toxic reactions.
Deciphering the broadband absorption of eumelanin in solution phase
Authors: Singh Abhishek , Mason Thomas , Freeman Benny , Izgorodina Ekaterina 
Published: November 2022

Abstract
Melanin, a bio-polymer responsible for visible pigmentation in the human body, works as a protective layer in our skin by absorbing UV radiation and efficiently dissipating it into heat, preventing DNA damage. The primary structure of eumelanin, one of the two main forms of melanin, is presumed to be a co-polymer of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole- 2-carboxylic acid (DHICA) monomers, with DHI being the major component. The solution phase investigation into the origin of broadband monotonic absorption spectrum of melanin has been unfolded through the polymerization of dopamine and L-DOPA, the molecular precursors of DHI and DHICA, respectively, in an ionic liquid (IL). This study reveals that the evolution of the electronic absorption spectrum of polymerized L-DOPA did not mimic the electronic spectrum of eumelanin, which was attributed to their inability to form stable redox states, as elucidated via structural characterization. Contrary to that, polymerized DA (pDA) mimics the eumelanin absorption spectrum, and the structural characterization of the polymerization process performed with 1H and 13C NMR and DOSY spectroscopy allowed us to identify chromophores responsible for the absorption profile of pDA. Furthermore, identified chromophores were subjected to quantum chemical calculations and their absorption spectra not only supported their presence in the experimental UV-Vis spectra but also allowed us to identify their gradual evolution during polymerisation. The knowledge of chromophores responsible for the optical properties of melanin will undoubtedly result in their increased application in functional materials.
Knowledge, Attıtudes and Behavıors of Somalia Female University Students about Cervıcal Cancer, Hpv and Hpv Vaccine: Cross-Sectional Study
Authors: ALTUNKUREK Şeyma Zehra , ŞAHİN Eda , Mohamed Samira Hassan 
Published: November 2022

Abstract
Background: Awareness and knowledge of cervical cancer and HPV are consistently poor in developing countries. In addition, there is insufficient evidence for young people's knowledge and understanding of cervical cancer, risk factors, screening and HPV vaccination in these countries. This study was conducted to determine the knowledge, attitudes and behaviors of students studying at a university in Somalia about cervical cancer and prevention methods.
Methods: This cross-sectional study was conducted among students of the Faculty of Health Sciences at a private university in Mogadishu, Somalia, between January to March 2021.
The sample of study consisted of a total of 220 female students. The data of the study were collected using a questionnaire consisting of 32 questions evaluating the knowledge and attitudes of the students about cervical cancer, HPV and HPV vaccine.
Results:In our study, 59.1% of the participants stated that they had heard of cervical cancer before, 69.1% did not know that it was fatal, 49.1% stated that it was preventable, 48.2% did not know the causes of cervical cancer, and 2.7% had a family history of cervical cancer. In addition, it was determined that 75.9% of the participants did not know that HPV caused cervical cancer. When the knowledge status of the participants about HPV and HPV vaccine was examined, it was determined that 55% of them had not heard of HPV before. When asked about the transmission ways of HPV; respectively, kissing (73.2%), sexual intercourse (58.2%) and using the things of individuals infected with HPV (41.8%). None of the participants had received the HPV vaccine. 72.3% of them stated that they did not have any information as the reason for not being vaccinated. 40.9% of the participants stated that both boys and girls should be vaccinated, and 63.6% stated that they did not know at what age they should be vaccinated. In addition, 71.4% stated that they did not know that the HPV vaccine protects against sexually transmitted diseases. The results show that there is a statistically significant relationship only between the economic situation and the awareness variable (p<0.005). It was concluded that the awareness of the participants, whose economic situation was good, was statistically high.
Conclusion: Our first study on the subject in Somalia, it has been revealed that the level of knowledge and vaccination rates of female university students studying in the field of health sciences about HPV vaccine, cervical cancer and prevention methods are insufficient. In future studies, the reasons for these inadequacies can be revealed with more comprehensive studies.