bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of COVID‐19 on the management of neuroendocrine tumors (NETS): An international NET CONNECT survey of NET patients and healthcare professionals treating net patients
Authors: Cives Mauro , Hernando Jorge , Lamarca Angela , Bouvier Catherine , Caplin Martyn , Pavel Marianne 
Published: August 2022

AbstractThe COVID‐19 outbreak has added complexity in the management of patients with neuroendocrine tumors (NETs). Little information is currently available regarding the real impact of the pandemic in current practice. The present study aimed to capture patients' and healthcare professionals' experiences on how the NET management has changed during the pandemic and how it should be modified in a foreseeable post‐pandemic environment. Physicians and nurses working in ENETS Centers of Excellence or other hospitals with high volume of NET patients (n = 48), as well as NET patients residing worldwide (n = 353), were asked to respond to two online anonymous surveys addressing different aspects of NET care. Deferred diagnoses, delayed surveillance procedures and postponed elective surgeries were among the main negative consequences of the COVID‐19 outbreak according to 40%, 54% and 46% of healthcare professionals (HPs) respectively. Somatostatin analogs were increasingly used as bridging strategy for delaying surgery based on the views of 31% of HPs and were self‐injected or delivered by home care services more frequently than before the initiation of the pandemic (53% of patients during the pandemic vs. 44% before the pandemic). Multidisciplinary tumor boards kept their usual schedule according to 58% of HPs, but were held virtually in the 77% of cases. The contact with healthcare professionals was maintained by remote methods more often than in the past (69% of patients), but only 34% of patients (59% among subjects < 41 years) would prefer telemedicine to face‐to‐face consultations in the future. New health policy measures should guarantee the highest standard of treatment to NET patients, regardless of the trajectory followed by the COVID‐19 pandemic in the next months. Pros and cons of telemedicine should be carefully weighted before systematic implementation.
Clinical scoring systems for the risk of cardiovascular autonomic neuropathy in type 1 and type 2 diabetes: A simple tool
Authors: Menduni Marika , D'Amato Cinzia , Leoni Martina , Izzo Valentina , Staltari Mariateresa , Greco Carla , Abbatepassero Andrea , Seminara Giuseppe , D'Ippolito Ilenia , Lauro Davide , Spallone Vincenza 
Published: August 2022

AbstractThis study was aimed at developing a clinical risk score for cardiovascular autonomic neuropathy (CAN) for type 1 and type 2 diabetes. In a retrospective cross‐sectional one‐centre study in an unselected population, 115 participants with type 1 diabetes (age 41.1 ± 12.2 years) and 161 with type 2 diabetes (age 63.1 ± 8.9 years), well‐characterized for clinical variables, underwent standard cardiovascular reflex tests (CARTs). Strength of associations of confirmed CAN (based on 2 abnormal CARTs) with clinical variables was used to build a CAN risk score. CAN risk score was based on resting heart rate, HbA1c, retinopathy, nephropathy, cardiovascular disease in both type 1 and type 2 diabetes, and on HDL cholesterol, systolic blood pressure, and smoking in type 1 diabetes or insulin treatment and physical activity in type 2 diabetes (range 0‐10). In type 1 diabetes, CAN risk score showed an area under the ROC curve (AUC) of 0.890 ± 0.034, and at cut‐off of 4 sensitivity of 88%, specificity of 74.4%, and negative predictive value (NPV) of 95.7% for confirmed CAN. In type 2 diabetes, CAN risk score showed an AUC of 0.830 ± 0.051 and at the cut‐off of 4 sensitivity and specificity of 78.6% and 73.5%, respectively, and NPV of 97.3% for confirmed CAN. These newly developed CAN risk scores are accessible in clinical practice and, if confirmed in a validation study, they might identify asymptomatic individuals with diabetes at greater risk of CAN to be referred to CARTs, thus limiting the burden of a universal screening.
Filler injections in the pre‐auricular space: Be aware of the parotid gland
Authors: Schelke Leonie , Schoonen Tamar , Velthuis Peter J. 
Published: August 2022

AbstractBackgroudIn recent years the pre‐auricular area is increasingly used for filler injections.AimsAssessment of depth of the subcutaneous fat and the process of realtime filler injection.Materials & MethodsUltrasonographic data of two cases and a video are studied.ResultsThese show how filler injections may very easily be delivered inside the parotid gland. This may go unnoticed by injector and client.DiscussionThis study and data from literature prove that filler injections in the pre‐auricular area may end up inside or in the vicinity of the parotid gland, and this can lead to an inflammatory response.ConclusionIt is recommended to be careful with filler injections in this area. Prior sonographic assessment of the subcutaneous depth in this area is advised.
Doing diversity in the legal profession in England and Wales: why do disabled people continue to be unexpected?
Authors: FOSTER DEBORAH , HIRST NATASHA 
Published: August 2022

AbstractA call for socio‐legal scholars to interrogate the relationship between law, disablement, ableism, and justice was recently made in this journal. Using research co‐produced with disabled people in the legal profession in England and Wales, this article responds by asking why, in a profession that has made a significant investment in widening access and diversity, do disabled people continue to be unexpected? The apparent absence of disabled people in the profession belies a complex reality. Identity concealment is widespread and maintained by genuine fears of career disadvantage. The effect of this is that disabled legal professionals are unable to access their legal rights to reasonable adjustments. Findings suggesting that status, success, and economic power offer little protection from ill treatment exposes the contradictory position that disabled people occupy in a profession that has increasingly favoured ‘business case’ over social justice diversity discourses.
Strategy as Practice Research: Reflections on its Rationale, Approach, and Contributions
Authors: Prashantham Shameen , Healey Mark P. 
Published: August 2022

AbstractStrategy as practice (SAP) research has developed into an established area of study, and the Journal of Management Studies (JMS) has played an important role in this as a hospitable outlet, including via a foundational special issue in 2003. This article offers a bird's eye view of the domain and a ready source of relevant literature to both seasoned scholars and newcomers to this topic. We make three observations that reflect both the JMS thematic collection and the wider literature on SAP and help to shed light on some of the key tensions facing scholars who seek to develop a distinct body of research. First, in terms of the rationale for SAP research, this body of work has grappled with its framing as building upon, yet distinct from strategy process research, to delve into practices within strategy process. Second, in terms of the approach to research (and community‐building), SAP research has reflected European intellectual roots which has helped to deliver on its broad research purpose but has perhaps also impeded its impact on more mainstream strategy. Third, in terms of the contribution of SAP research, there has been a large volume of high quality work, appearing in well‐regarded journals, generating a considerable diversity of perspectives.
Oral health‐related quality of life in patients with osteoarthritis of the temporomandibular joint—Results of a systematic review
Authors: Ning Wanchen , Schmalz Gerhard , Li Ping , Huang Shaohong 
Published: August 2022

AbstractObjectivesThe aim of this systematic review was to assess the oral health‐related quality of life (OHRQoL) of patients with osteoarthritis (OA) of the temporomandibular joint (TMJ).MethodsThis systematic literature search applied the search terms "oral health‐related quality of life AND osteoarthritis of jaw OR arthritis of temporomandibular joint AND oral health‐related quality of life" in PubMed, Medline, Web of Science and Scopus. Eligibility criteria were publication until 31 August 2021, examination of children or adults with OA of TMJ, reporting of any OHRQoL measurement and a full text in English language. Two different, independent and experienced reviewers performed this systematic literature search. The analysis of respective data was qualitative. For quality appraisal, the available checklist from the Agency for Healthcare Research and Quality (AHRQ) was applied.ResultsOut of 102 findings, eight studies were included in qualitative analysis. Seven clinical investigations were performed in adults aged between 34 and 43 years. The other included study was performed on children. The quality of two studies was moderate, and six studies were evaluated as of high quality. Most studies applied the 14‐item short form of the oral health impact profile (OHIP 14) for assessment of OHRQoL. OHIP 14 ranged between 9.24 and 38.86 points in means of sum score. Comparison with healthy individuals revealed worse OHRQoL of OA patients in two studies. Associations between OHRQoL with either oral health, general quality of life or disease‐related parameters were rarely reported and heterogeneous. Five of the included studies reported subscales of OHIP 14, showing an impairment in all subscales.ConclusionsThere are hints that patients with OA of the TMJ show a reduced OHRQoL. More studies are needed, especially regarding oral health, disease‐related parameters and pain intensity and its potential influence on OHRQoL.
Maxillary overdenture on three implants retained by low‐profile stud attachments – A prospective cohort study
Authors: Mo Arild , Hjortsjö Carl , Jokstad Asbjørn 
Published: August 2022

AbstractBackgroundClinical data are needed on long‐term outcomes of removable implant‐supported prostheses in the fully edentulous maxilla as a function of the number of implants, effects of the attachment system and other clinical variables.ObjectiveTo restore individuals with an edentate maxilla with a metal‐reinforced removable prosthesis without palatal coverage retained by low‐profile stud attachments on three implants.MethodsThe regional ethics committee approved a prospective cohort study that included all consecutive patients treated in a private speciality clinic. Primary outcomes were patients reported, that is denture satisfaction scale and oral health‐related quality of life – OHIP‐20. Secondary outcomes were implant‐ (bone loss, implant complications and peri‐implant conditions) and prosthesis‐related (prosthesis complications, maintenance needs and mucosa condition).ResultsThirty‐two study participants were recruited between March 2007 and October 2016 and followed for a minimum of five years. According to Kruskal–Wallis tests, the OHIP‐20 and Denture Satisfaction Scale questionnaire pre‐treatment scores differed significantly. After an average of 6.7 years, peri‐implant bone loss of more than 2 mm was observed on 17% of all implants, while no or minor bone loss was seen on 38%. The estimated success of implants was 0.95 at 168 months. The estimated success of the prosthesis, that is no adverse events or need for any repairs, was 0.55 at 156 months.ConclusionThe positive findings in the current clinical study strengthen the notion that for many individuals with an edentulous maxilla, a removable prosthesis retained by three implants fitted with low‐profile stud‐attachment is a reliable technical solution.
The effects of tongue elevation using a weighted plastic bottle on the tongue pressure and activity of suprahyoid muscles
Authors: Nanto Tomoki , Ono Takahiro , Hori Kazuhiro , Murakami Kazuhiro , Uchiyama Yuki , Maeda Yoshinobu , Domen Kazuhisa 
Published: August 2022

AbstractBackgroundA rise in tongue pressure coincides with an increase in the suprahyoid muscle activity.ObjectivesThe aim was to investigate the effects of holding a weighted plastic bottle on tongue pressure and the suprahyoid muscle activity.MethodsEighteen participants (8 men and 10 women; mean age 42 ± 16 years) participated in this study. All participants had no history of speech, language, hearing or swallowing disorders and no tooth loss, and they did not require dentures. Healthy participants held gauzes connected with a plastic bottle with increasing resistive loads of 0 g, 250 g, 500 g and 750 g, between their palate and tongue. The maximum tongue pressure and average tongue pressure were measured during a 5 s hold. The average tongue pressure was defined as the mean tongue pressure data in each task. The suprahyoid muscle activity was measured using the electromyogram (EMG). The root mean square of the EMG signals measured while lifting different loads and while performing the head lifting exercises was compared. All variables were examined using the Friedman's test and Wilcoxon signed‐rank test.ResultsThe maximum tongue pressure (p < .05) and average tongue pressure values (p < .05) increased gradually in the anterior‐median region with increasing resistive loads, and the root mean square amplitudes for 250 g, 500 g and 750 g were not significant compared with head lifting exercises.ConclusionThese results indicated that plastic bottle holding could be a potential strength training tool for the tongue and the suprahyoid muscles.
Energy, protein and redox metabolism underlying adaptive responses in New Zealand versus North American Holstein cows in pasture‐based dairy systems
Authors: Jorge‐Smeding Ezequiel , Carriquiry Mariana , Casal Alberto , Armand‐Ugon Diego , Mastrogiovanni Mauricio , Trotschansky Andrés , Mendoza Alejandro , Astessiano Ana L. 
Published: August 2022

AbstractThis study explored the metabolic adaptions to grazing conditions of two Holstein genetic strains (GS; North American, NAH; New Zealand, NZH) in two feeding strategies (FS; restricted, P30, vs. maximised, PMAX, grazing). Four groups (NAH‐P30, NZH‐P30, NAH‐PMAX and NZH‐PMAX; n = 10 cows each) were compared between −45 and 180 days in milk (DIM). NZH cows had lower (p = 0.02) fat and protein corrected milk (FPCM) yield and a tendency for lower (p = 0.09) body condition score concomitantly with a trend (p < 0.07) for higher average plasma insulin and lower (p = 0.01) 3‐methylhistidine (3MH) at −45 DIM than NAH. Plasma glucose tended to be affected by the triple interaction GS × FS × DIM (p = 0.06) as it was similar between NAH‐P30 and NZH‐P30, but higher (p ≤ 0.02) for NZH‐PMAX than NAH‐PMAX except at 21 DIM. The physiological imbalance index was affected by the GS × FS interaction (p < 0.01) as it was lower (p < 0.01) only for NZH‐PMAX versus NAH‐PMAX. NZH cows had higher (p = 0.01) plasma thiobarbituric acid reactive substances at −45 DIM and tended to have higher protein carbonyls (p = 0.10) and superoxide dismutase (SOD) activity (p = 0.06) on average, and had higher (p < 0.01) α‐tocopherol during mid‐lactation than NAH Regarding the FS, FPCM was similar (p = 0.12) among them, but PMAX cows had higher (p < 0.01) plasma non‐esterified fatty acids and 3MH, and lower insulin (p < 0.01) than P30 at 100 DIM. PMAX cows showed higher average SOD activity (p = 0.01) and plasma α‐tocopherol at 100 and 180 DIM (p < 0.01). Under grazing, NZH cows can have a better energy status and lower muscle mobilisation but a higher redox reactivity. Maximising grazing can worsen energy status and muscle mobilisation while improving antioxidant response with no effect on FPCM.
Advanced emergency braking system reduces the risk of motor vehicle collisions caused by falling asleep while driving in patients with untreated obstructive sleep apnea
Authors: Arita Aki , Kumagai Hajime , Sawatari Hiroyuki , Hoshino Tetsuro , Konishi Noriyuki , Murase Yoko , Urabe Ayako , Nomura Atsuhiko , Sasanabe Ryujiro , Shiomi Toshiaki 
Published: August 2022

SummaryObstructive sleep apnea leads to excessive daytime sleepiness and cognitive dysfunction, which are risk factors for motor vehicle collisions. We aimed to clarify if vehicles with an advanced emergency braking system could reduce motor vehicle collisions caused by falling asleep while driving among patients with untreated obstructive sleep apnea. We enrolled patients with untreated obstructive sleep apnea who underwent polysomnography. The questionnaires included the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, history of drowsy driving accidents, and use of an advanced emergency braking system. Multivariate analysis was performed, and odds ratios and 95% confidence intervals were calculated. This study included 1097 patients (mean age, 51.2 ± 12.9 years). Collisions caused by falling asleep while driving were recorded in 59 (5.4%) patients, and were more frequently observed in vehicles without an advanced emergency braking system (p = 0.045). Multivariate analysis showed that these collisions were associated with use of an advanced emergency braking system (odds ratio [95% confidence interval]: 0.39 [0.16–0.97], p = 0.04), length of driving (2.79 [1.19–6.50], p = 0.02), total sleep time (2.40 [1.62–3.55], p < 0.0001), sleep efficiency (0.94 [0.90–0.98], p = 0.003) and periodic limb movement index (1.02 [1.01–1.03], p = 0.004). The collision risk caused by falling asleep while driving in vehicles with an advanced emergency braking system was significantly lower. This study indicates that advanced emergency braking systems may be a preventive measure to reduce motor vehicle collisions among patients with untreated obstructive sleep apnea.
Comparison of biochemical and hematologic values obtained via jugular venipuncture and peripheral intravenous catheters in dogs
Authors: Guarino Aria L. , Specht Andrew J. , Beatty Sarah S. K. , O'Kell Allison L. 
Published: August 2022

AbstractBackgroundSampling from a peripheral intravenous catheter (PIVC) might be a more efficient and less traumatic collection of blood for serum biochemistry (SB) or CBC than direct venipuncture (DV). Agreement between results of samples obtained by these methods has not been evaluated in dogs.ObjectivesThe primary objectives were to determine whether sampling from PIVC could be used in place of DV for dogs. We hypothesized DV and PIVC samples would have clinically equivalent SB and CBC results.AnimalsSixty‐one client‐owned dogs were included in each study arm.MethodsThis was a partially randomized method‐comparison study. Paired DV and PIVC samples obtained within 1 to 2 minutes after, or approximately 24 hours after, placement of a PIVC in a cephalic vein were evaluated for agreement and bias using percentage difference plots (with a priori application of consensus total allowable error), Bland‐Altman analysis, Passing‐Bablok regression analysis, Wilcoxon signed rank test, and McNemar's test.ResultsThere was statistically and clinically acceptable agreement and no bias between sampling methods for the majority of results. Analytes with the most frequent disagreement were aspartate aminotransferase, total bilirubin, potassium, bicarbonate, and leukocyte differential counts, as well as red blood cell count, hemoglobin, hematocrit, and packed cell volume in the hospitalized PIVC sampling group. Few observed differences would change clinical decision making.Conclusions and Clinical ImportancePIVC sampling can provide generally acceptable SB and CBC results for most dogs, but clinicians should be aware of a few values for which disparate results might occasionally be obtained.
Taxonomic and functional dynamics during chytrid epidemics in an aquatic ecosystem
Authors: Li Luen‐Luen , Delgado‐Viscogliosi Pilar , Gerphagnon Mélanie , Viscogliosi Eric , Christaki Urania , Sime‐Ngando Télesphore , Monchy Sébastien 
Published: August 2022

AbstractFungal parasitism is common in plankton communities and plays a crucial role in the ecosystem by balancing nutrient cycling in the food web. Previous studies of aquatic ecosystems revealed that zoosporic chytrid epidemics represent an important driving factor in phytoplankton seasonal successions. In this study, host–parasite dynamics in Lake Pavin (France) were investigated during the spring diatom bloom while following chytrid epidemics using next generation sequencing (NGS). Metabarcoding analyses were applied to study changes in the eukaryotic microbial community throughout diatom bloom–chytrid epidemics. Relative read abundances of metabarcoding data revealed potential “beneficiaries” and “victims” during the studied period. Subsequently, metatranscriptomic analyses on samples before and during the chytrid epidemic unveiled the active part of the community and functional/metabolic dynamics in association with the progress of chytrid infection. Diatom functions involving lipases, transporters, histones, vacuolar systems, the proteasome, proteases and DNA/RNA polymerases were more abundant during the diatom bloom. Chytrid functions related to a parasitic lifestyle including invasion, colonization and stress tolerance were up‐regulated during the chytrid epidemic. In addition, functions related to the degradation/metabolism of proteins, lipids and chitin were in higher proportion in the community during the epidemic event. Results of NGS and bioinformatics analyses offered a panorama of dynamic biodiversity and biological functioning of the community.
Intelligent pixel‐level detection of multiple distresses and surface design features on asphalt pavements
Authors: Zhang Allen A. , Wang Kelvin C. P. , Liu Yang , Zhan You , Yang Guangwei , Wang Guolong , Yang Enhui , Zhang Hang , Dong Zishuo , He Anzheng , Xu Jie , Shang Jing 
Published: August 2022

AbstractSimultaneous pixel‐level detection of multiple distresses and surface design features on complex asphalt pavements is a critical challenge in intelligent pavement survey. This paper proposes a deep‐learning model named ShuttleNet to provide an efficient solution for this challenge by implementing robust semantic segmentation on asphalt pavements. The proposed ShuttleNet aims at repeating the encoding–decoding round freely or even endlessly such that the contexts at different resolution levels can be learned and integrated many times for enhanced latent representations. Additionally, a new and efficient connection method called memory connection is also proposed in the paper and deployed in the ShuttleNet model to provide shortcut connections between successive encoding–decoding rounds. The proposed memory connection can partially or entirely carry the decoded information at different resolution levels into the next encoding–decoding round. Pairing 3D pavement images with 2D pavement images, the proposed ShuttleNet model is applied to detect multiple distresses and surface design features on asphalt pavements simultaneously, including pavement cracks, potholes, sealed cracks, patches, markings, expansion joints, and the pavement background. Experimental results demonstrate that the mean F‐measure and mean intersection‐over‐union attained by the recommended architectural variation of the proposed ShuttleNet model on 1500 testing image pairs are 92.54% and 0.8657 respectively. According to the performance comparisons using both private and public datasets, the proposed ShuttleNet model can yield a noticeably higher detection accuracy, compared with four state‐of‐the‐art models for semantic segmentation.