bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myélome multiple anaplasique : à propos d’un cas clinique
Authors: Mechtoune Mustapha , Lahlimi Fatima Zahra , Tazi Illias , Krifch Mouad , Chakour Mohamed , Elbaroudi Oussama , Amer Ohamed Ait , El Yahyaoui Hicham 
Published: July 2022

Le myélome multiple anaplasique (MMA) est une forme rare et très agressive, caractérisée par le développement d'un clone de plasmocytes tumoraux immatures et peu différenciés avec une atteinte extra médullaire fréquente. La morphologie anaplasique peut être présente lors du diagnostic initial ou peut apparaître plus tard au cours de la maladie. Le MMA est très résistant à la chimiothérapie et se caractérise par une mauvaise réponse aux nouvelles thérapies et un pronostique sombre. Nous rapportons, le cas d’un patient âgé de 57 ans suivi pour myélome multiple à IgG Kappa, qui présente une rechute extra médullaire en post autogreffe en myélome multiple anaplasique.

English title: Anaplastic multiple myeloma: a case report
Anaplastic multiple myeloma (AMM) is a rare and very aggressive form of myeloma, characterized by the development of an immature and poorly differentiated tumor plasma cell clone with frequent extra marrow involvement. Anaplastic morphology may be present at initial diagnosis or may appear later in the course of the disease. AMM is highly resistant to chemotherapy and is characterized by a poor response to new therapies and a poor prognosis. We reported the case of a 57-year-old patient followed for IgG Kappa multiple myeloma who presented with an extramedullary relapse post autologous bone marrow transplantation into anaplastic multiple myeloma.
A Geoeconomic Planning and Evaluation Model for Artisanal Small-Scale Gold Mining in Ghana
Authors: Gyebuni R. , Ansah K. O. , Mireku-Gyimah D. 
Published: July 2022

Following calls for comprehensive National Action Plans (NAPs) that outline training programmes for the handling of mercury and strategies for reducing emissions from artisanal and small-scale gold mining (ASGM) under the Minamata Convention, other follow-up calls intensified the need for the formalisation or regulation of ASGM in the sector. Aside from the precarious emission of mercury and hazards to the environment, the ASGM sector resorts to unsafe methods for exploiting minerals due to inadequate funding. It is not surprising that anti-mining groups constantly advocate against mining in general as a result of the harm unprofessional ASGM operators expose man and the environment to. In this light, several studies have been conducted to propose safe techniques of exploiting minerals by ASGM operators and the need for governments to regulate the sector through legal instruments. Unfortunately, the problems of ASGM seem to linger on. Notwithstanding, much attention has not been given to the formulation of procedures for accurate resource estimation and subsequent feasibility studies of ASGM, which could probably be a major cause of ASGM challenges. This study proposes Inverse Distance Weighting (IDW) technique for estimating the concentration of alluvium gold. The IDW method was successfully applied to the alluvial deposit of the Mpeasem Gold Project, and practical results were obtained for economic evaluations. The total volume of alluvial gold deposits was 3.4 Mm3 at an average grade of 0.46 g/m3. Economic evaluation yielded a net present value (NPV) and internal rate of return (IRR) of USD 2.8 M and 48%, respectively. The results indicate that reasonable data from outcrop sampling, pitting and trenching, and detailed cost estimates can present a more compelling case for funding. This way, the funding inadequacies which contribute to the use of shortcuts and unsafe tools, materials, and methods can be minimised.
ENVOLVIMENTO DA COMUNIDADE DE MUICHI NA TOMADA DE DECISÃO SOBRE A GESTÃO DOS RECURSOS FLORESTAIS NO DISTRITO DE NIPEPE, NORTE DE MOÇAMBIQUE
Authors: De Andrade Amândio Castro , Ali Diolene  Francisco , Muachapeu Yurissan Das Nuros António , Tamele Isolda Rosalina Ilídio Chuva 
Published: July 2022

O presente estudo foi desenvolvido na província de Niassa, Distrito de Nipepe, especificamente na comunidade de Muichi com o objetivo de avaliar o envolvimento da comunidade local na tomada de decisão sobre o manejo de recursos florestais. Assim, para responder ao objetivo do estudo, foram entrevistados 109 entrevistados, sendo: autoridades tradicionais (3), membros de comitês de gestão de recursos naturais (5), membros da comunidade (95), representantes do setor privado (03) e de ONGs (3). Os dados foram obtidos por meio do uso de amostragem de bolas de neve sem probabilidade ou amostragem de bolas de neve, técnicas como levantamento de questionário, entrevistas semiestrusas, conversas informais, registros institucionais ou análise documental e observação direta de campo. Os dados foram analisados no programa Microsoft Excel 2019 e no IBM SPSS Statistics 26 com base na análise de conteúdo e correspondência de padrões que consiste em agrupar as respostas semelhantes dos respondentes em suas categorias correspondentes de informação e explicar as diferenças para que as conclusões possam ser tiradas. Observou-se que a comunidade tem baixo nível de controle sobre os recursos florestais, e sua participação no processo de tomada de decisão tem sido limitada devido a fatores como: a não representação da comunidade nos conselhos consultivos distritais, a falta de recursos financeiros, a falta de recursos humanos para auxiliar no processo de fiscalização tem sido o fator que mais cria dificuldade no processo de fiscalização dos recursos florestais.
Colorimetric Properties of Disperse-dyed Polyester Fabrics Treated with Nano TiO2
Authors: Setthayanond Jantip , Suwanruji Potjanart , Tooptompong Porntip , Tungtriratanakul Sinee 
Published: July 2022

In this work, the influence of nano titanium dioxide (TiO2) finishing on colorimetric properties of polyester fabrics dyed with mono-azo disperse dyes was examined in terms of the degree of shade change, color strength reduction and the percentage of dye lost from the fabrics and color fastness to washing. A self-cleaning effect imparted by nano TiO2 not only removes unwanted stains from polyester fabrics but also the dye molecules situated in the area nearby the fiber surface. Changes in colorimetric properties of the fabrics dyed with Disperse Violet 33, Disperse Red 167.1 and Disperse Blue 79.1 dyes were, therefore, examined. Shade change and reduction in color strength were observed, in addition, the dye quantity within the fiber decreased as a result of nano TiO2 treatment. Higher amount of nano TiO2 brought about a stronger effect on changes in colorimetric values, quantity of lost dye and color fastness to washing of the dyed polyester fabrics. A similar tendency was observed on these 3 mono-azo dyes. A way to achieve optimal functional performance of nano TiO2 finishing with minimal effect on colorimetric properties of the disperse dyes on polyester is by employing low nano TiO2 content and 0.05 % nano TiO2 is recommended in this work. Under such conditions, the color properties of the dyed fabrics were less influenced and in acceptable level, moreover, the resulting color fastness to washing was not affected and comparable to those exposed to reduction clearing process.
HIGHLIGHTS

Nano TiO2 has been widely known to offer self-cleaning effect to textiles, especially polyester, at the same time, it may also affect the color and fastness properties of disperse dye on polyester
Disperse dyes can be destroyed by nano TiO2 present on polyester fibers. This causes a change in shade, color strength, dye loss and fastness to washing of the disperse-dyed polyester
An appropriate amount of applied nano TiO2 onto polyester fabric is considered to maintain self-cleaning function performance with minimal effect on colorimetric properties of the disperse dyes on polyester

GRAPHICAL ABSTRACT
Synergistic antitumor effects of 5-FU and Apatinib on papillary thyroid cancer in vitro and in vivo
Authors: Meng Min , Ye Xin , Yang Xia , Huang Guanghui , Wei Zhigang , Ni Yang , Li Wenhong , Han Xiaoying , Wang Jiao 
Published: July 2022

IntroductionPapillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy with increased incidence rapidly occurring in most countries. The study aimed to investigate the antitumor effects of the combination of 5-FU and Apatinib on PTC.Material and methodsTPC-1 and SW579 cells were treated with 5-FU, Apatinib, or a combination of 5-FU and Apatinib. Cell viability was assessed by the CCK-8 assay. Edu staining and colony formation were used to evaluate the cell proliferation ability. Flow cytometry was used to analyze the cell apoptosis. Wound healing and the Transwell assay were conducted to analyze cell migration and invasion. The angiogenesis of TPC-1 and SW579 cells was assessed by conducting the tube formation assay. Xenograft tumor models were established by injecting TPC-1 cells into nude mice. Expressions of CD31, VEGFA, and VEGFR2 were determined using immunofluorescence and Western blotting.ResultsCompared with 5-FU or Apatinib treatment alone, the combination of 5-FU and Apatinib produced stronger suppressive effects on cell proliferation, migration, invasion, and angiogenesis. An in vivo experiment showed that the combination of 5-FU and Apatinib strongly suppressed tumor growth. The combination of 5-FU and Apatinib remarkably suppressed expressions of CD31, VEGFA, and VEGFR2, associated with angiogenesis.ConclusionsOur data demonstrated that 5-FU combined with Apatinib therapy obtained synergistic antitumor effects in PTC, compared with either 5-FU or Apatinib alone by down-regulating VEGFA/VEGFR2 signaling pathways.
Pengembangan E-LKPD Berbasis Guided Dicovery Learning untuk Meningkatkan Kemampuan Berpikir Kritis Siswa
Authors: Habsyi Rusdi , R. M. Saleh Rusmin , Isman M. Nur  
Published: July 2022

Salah satu permasalahan yang dihadapi Guru pada materi persamaan lingkaran adalah belum adanya bahan ajar yang dapat menfasilitasi peserta didik dalam kegiatan-kegiatan terstruktur seperti Lembar Kegiatan Peserta Didik (LKPD). Penelitian ini bertujuan untuk mengembangkan e-LKPD persamaan lingkaran berbasis Guided Discovery Learning untuk meningkatkan kemampuan berpikir kritis. Penelitian ini merupakan penelitian pengembangan dengan menggunakan model ADDIE (Analysis, Design, Development, Implementation, Evaluation). Kami menggunakan instrumen lembar validasi, respon peserta didik, observasi, wawancara, dan pre-test dan post-test. Berdasarkan hasil penelitian ditemukan bahwa: (1) produk e-LKPD untuk materi dan media dikategorikan sangat valid; (2) siswa memberikan respon sangat baik; (3) e-LKPD dapat meningkatkan kemampuan berpikir kritis siswa. Hasil penelitian ini juga menyarankan bahwa ditemukan beberapa kendala saat menggunakan aplikasi tersebut, sehingga perlu dilakukan pengembangan lebih lanjut.
A 10-year global monthly averaged terrestrial net ecosystem exchange dataset inferred from the ACOS GOSAT v9 XCO2 retrievals (GCAS2021)
Authors: Jiang Fei , Ju Weimin , He Wei , Wu Mousong , Wang Hengmao , Wang Jun , Jia Mengwei , Feng Shuzhuang , Zhang Lingyu , Chen Jing M. 
Published: July 2022

Abstract. A global gridded net ecosystem exchange (NEE) of CO2
dataset is vital in global and regional carbon cycle studies. Top-down
atmospheric inversion is one of the major methods to estimate the global
NEE; however, the existing global NEE datasets generated through inversion
from conventional CO2 observations have large uncertainties in places
where observational data are sparse. Here, by assimilating the GOSAT ACOS v9
XCO2 product, we generate a 10-year (2010–2019) global monthly
terrestrial NEE dataset using the Global Carbon Assimilation System, version
2 (GCASv2), which is named GCAS2021. It includes gridded (1∘×1∘), globally, latitudinally, and regionally
aggregated prior and posterior NEE and ocean (OCN) fluxes and prescribed
wildfire (FIRE) and fossil fuel and cement (FFC) carbon emissions. Globally,
the decadal mean NEE is -3.73±0.52 PgC yr−1, with an interannual
amplitude of 2.73 PgC yr−1. Combining the OCN flux and FIRE and FFC
emissions, the net biosphere flux (NBE) and atmospheric growth rate (AGR) as
well as their inter-annual variabilities (IAVs) agree well with the
estimates of the Global Carbon Budget 2020. Regionally, our dataset shows that
eastern North America, the Amazon, the Congo Basin, Europe, boreal forests, southern
China, and Southeast Asia are carbon sinks, while the western United States, African
grasslands, Brazilian plateaus, and parts of South Asia are carbon sources.
In the TRANSCOM land regions, the NBEs of temperate N. America, northern
Africa, and boreal Asia are between the estimates of CMS-Flux NBE 2020 and
CT2019B, and those in temperate Asia, Europe, and Southeast Asia are
consistent with CMS-Flux NBE 2020 but significantly different from CT2019B.
In the RECCAP2 regions, except for Africa and South Asia, the NBEs are
comparable with the latest bottom-up estimate of Ciais et al. (2021).
Compared with previous studies, the IAVs and seasonal cycles of NEE of this
dataset could clearly reflect the impacts of extreme climates and
large-scale climate anomalies on the carbon flux. The evaluations also show
that the posterior CO2 concentrations at remote sites and on a regional
scale, as well as on vertical CO2 profiles in the Asia-Pacific region,
are all consistent with independent CO2 measurements from surface flask
and aircraft CO2 observations, indicating that this dataset captures
surface carbon fluxes well. We believe that this dataset can contribute to
regional- or national-scale carbon cycle and carbon neutrality assessment
and carbon dynamics research. The dataset can be accessed at
https://doi.org/10.5281/zenodo.5829774 (Jiang, 2022).
Analysis of the relationship between yield in cereals and remotely sensed fAPAR in the framework of monitoring drought impacts in Europe
Authors: Cammalleri Carmelo , McCormick Niall , Toreti Andrea 
Published: July 2022

Abstract. This study analyses the relationship between satellite-measured fAPAR (Fraction of Absorbed Photosynthetically Active Radiation), which are continuously monitored by the European Drought Observatory (EDO) of the EU’s Copernicus Emergency Management Service, and crop yield data for cereals, which are collected by Eurostat. Different features of the relationship between annual yield and multiple time series of fAPAR, collected during different periods of the year, were investigated. Two key outcomes of the analysis were the identification of the period from March to October as that when the highest positive correlation between fAPAR and yield is detected in Europe on average, and February to May as the period when most of the negative correlation are observed. While both periods align well with the commonly assumed dynamic of the growing season, spatial differences are also observed across Europe. On the one hand, the Mediterranean regions report the highest correlation values (r > 0.8) and the longest continuous periods with positive statistically significant results (up to 7 months), covering most of the growing season. On the other hand, the central European region is characterized by the most limited positive correlation values, with only 2 months or less showing statistically significant results. While marked differences on the overall capability to capture the full dynamic of yield are observed across Europe, fAPAR anomalies seem capable to distinguish between drought and no/drought years in most of the cases if negative yield anomalies are used as a proxy variable for drought impacts.
Pemetaan Kawasan Politeknik Pertanian Negeri Samarinda Menggunakan Drone
Authors: Andrew Andrew Stefano 
Published: July 2022

Perubahan penggunaan lahan pada dasarnya tidak dapat dihindarkan dalam pelaksanaan pembangunan. Politeknik Pertanian Negeri Samarinda berdiri 1989-2021 beralamatkan di Gunung Panjang Provinsi Kalimantan Timur. Penelitian ini bertujuan pemetaan kawasan Politeknik Pertanian Negeri Samarinda. Metode menggunakan overlapping data pengukuran GPS dengan Peta BAPPEDA Kota Samarinda 2011-2031, pengolahan data drone dengan agisoft photoscan, overlay data drone dengan hasil data GPS dan peta BAPPEDA, dan hasil analisis kawasan di crosscheck dengan Citra Quick Bird. Hasil penelitian diperoleh peta kawasan Politeknik Pertanian Negeri Samarinda seluas 28,44 Ha, dengan batas wilayah sebelah Utara Politeknik Negeri Samarinda, sebelah Selatan pemukiman penduduk, sebelah timur pemukiman penduduk dan sebelah barat jalan. Karena belum adanya peta pengukuhan kawasan sehingga penelitian ini perlu dibuat. Pengukuhan suatu kawasan harus berdasarkan Peraturan Pemerintah Republik Indonesia Nomor 18 Tahun 2021 tentang hak pengelolaan, hak atas tanah, satuan rumah susun, dan pendaftaran tanah.
Pengaruh Imbangan Rumput Dan Konsentrat Terhadap Tinggi Pundak, Panjang Badan Dan Bobot Badan Domba Garut Jantan Umur 16-18 Bulan
Authors: Sanjaya Irwan , Rohayati Tati , Ayuningsih Budi 
Published: July 2022

Penelitian ini bertujuan untuk mengetahui pengaruh imbangan rumput dan konsentrat terhadap tinggi pundak panjang badan dan bobot badan domba Garut jantan umur enam belas hingga delapan belas bulan. Metode yang digunakan adalah metode eksperimental menggunakan Rancangan Acak Lengkap (RAL) dengan tiga perlakuan dan enam ulangan, sehingga jumlah ternak sebanyak 18 ekor domba Garut umur enam belas hingga delapan belas bulan dengan bobot badan rata-rata 33 kg dan dipelihara dalam kandang individual. Perlakuan yang digunakan adalah imbangan rumput dan konsentrat yaitu P1 (80% rumput + 20% konsentrat), P2 (60% rumput + 40% konsentrat) dan P3 (40% rumput+60% konsentrat). Variabel yang diamati terdiri dari tinggi pundak, panjang badan dan bobot badan. Hasil penelitian menunjukkan imbangan rumput dan konsentrat berbeda memberikan pengaruh yang sama terhadap tinggi pundak, panjang badan dan pertambahan bobot badan Domba Garut jantan umur 16 - 18 bulan.
EVALUASI PENAMPILAN REPRODUKSI SAPI PERAH FRIESIAN HOLSTEIN PADA BERBAGAI UMUR DI WILAYAH KERJA KOPERASI PETERNAKAN BANDUNG SELATAN
Authors: Tahjudin Taufiq Syaiful , Kusmayandi Tendy , Hadist Ibrahim 
Published: July 2022

Evaluasi terhadap penampilan reproduksi sangat penting, karena baik buruknya penilaian terhadap seekor sapi perah bergantung pula pada baik buruknya atau teratur tidaknya sapi tersebut dapat beranak. Penelitian ini bertujuan untuk mengetahui Evaluasi Penampilan Reproduksi melalui pengamatan angka Service per Conception (S/C), angka Post Partum Mating dan angka Days Open (DO) pada sapi perah Friesian Holstein di wilayah kerja Koperasi Peternakan Bandung Selatan. Metode penelitian yang digunakan adalah metode survey, dengan pengambilan data bersumber dari data sekunder dan primer. Pengambilan data sekunder diambil dari data rekording di kantor KPBS dengan pengambilan data masing-masing 10% dari setiap tingkatan umur yaitu umur ≤ 4 tahun sebanyak 40 ekor, umur 4-7 tahun sebanyak 171 ekor dan umur > 7 tahun sebanyak 21 ekor, sedangkan data primer menggunakan kuisioner kepada 215 peternak di wilayah kerja Koperasi Peternakan Bandung Selatan (KPBS). Hasil dari penelitian menunjukkan Service per Conception (S/C) ternak umur ≤ 4 tahun adalah 1.7, umur 4-7 tahun adalah 1.7 dan umur > 7 tahun adalah 2.0, Post Partum Mating ternak umur ≤ 4 tahun rata-rata adalah 98 hari, umur 4-7 tahun rata-rata adalah 86 hari dan umur > 7 tahun rata-rata adalah 85 hari dan Days Open (DO) ternak umur ≤ 4 tahun rata-rata adalah 112 hari, umur 4-7 tahun rata-rata adalah 104 hari dan umur > 7 tahun rata-rata adalah 113 hari. Kesimpulan dari penelitian ini bahwa Evaluasi Penampilan Reproduksi Sapi Perah Friesian Holstein di Wilayah Kerja Koperasi Peternakan Bandung Selatan dapat dikategorikan baik.
PENGARUH PEMBERIAN LIMBAH SAYUR DALAM RANSUM TERHADAP NILAI KECERNAAN BAHAN KERING, BAHAN ORGANIK DAN PROTEIN ITIK LOKAL (Anas Sp)
Authors: Asis Nirmala , Saelan Emy , Endrawaty Eny 
Published: July 2022

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian limbah sayur dalam ransum terhadap nilai kecernaan bahan kering, bahan organik dan protein itik lokal (Anas Sp). Rancangan yang digunakan adalah Rancangan Acak Lengkap dengan 4 perlakuan dan 4 ulangan. Perlakuan terdiri dari R0 (ransum komersial 100%), R1 (limbah sayur 10%), R2 (limbah sayur 15%) dan R3 (limbah sayur 20%). Parameter yang diamati yaitu kecernaan bahan kering, kecernaan bahan organik dan kecernaan protein. Data dianalisis menggunakan analisis of variance (ANOVA) dan jika terdapat perbedaan antara perlakuan dilakukan dengan uji lanjut BNT. Hasil penelitian pengaruh pemberian limbah sayur dalam ransum menunjukkan pengaruh yang sangat nyata (P<0,01) terhadap kecernaan bahan kering, kecernaan bahan organik dan kecernaan protein. Berdasarkan hasil penelitian dapat disimpulkan bahwa dengan pemberian limbah sayur dalam ransum itik lokal pada level yang berbeda dari 10%, 15% dan 20% berpengaruh nyata terhadap kecernaan bahan kering, kecernaan bahan organik dan kecernaan protein. Nilai kecernaan tertinggi dari semua parameter terdapat pada perlakuan R2= 15%.
PENGARUH PEMBERIAN TEPUNG ECENG GONDOK (Eichhornia crassipes) TERHADAP KUALITAS INTERIORDAN WARNAKUNINGTELUR ITIK MASTER
Authors: Huda Sandi Nurul , Herawati Ervi , Nurhayatin Titin 
Published: July 2022

Eceng gondok (Echhornia crassipes) adalah tumbuhan air yang hidup bebas di permukaan air, dapat berkembang dengan cepat dan dapat tumbuh sepanjang tahun. Eceng gondok memiliki nilai gizi yang cukup baik dapat dipertimbangkan sebagai bahan pakan untuk itik guna menekan biaya pakan yang melambung tinggi akibat terjadinya wabah Covid-19.Penelitian ini bertujuan untuk mengetahui pengaruh pemberian tepung eceng gondok (Eichhornia crassipes) terhadap kualitas interior dan warna kuning telur itik master. Penelitian dilakukan di Peternakan Citra Prawira di daerah Kampung Cigarukgak Desa Padamukti Kecamatan Pasirwangi Kabupaten Garut. Penelitian ini berlangsung selama 8 minggu dengan jumlah itik betina master 100 ekor berumur 68 minggu. Metode penelitian adalah eksperimental menggunakan Rancangan Acak Lengkap (RAL). Penelitian ini terdiri dari 4 pelakuan dan 5 ulangan. Perlakuan yang digunakan adalah pemberian tepung eceng gondok R0 (Ransum basal tanpa eceng gondok), R1 (Ransum basal yang mengandung5% tepung eceng gondok), R2 (Ransum basal yang mengandung 10% tepung eceng gondok), dan R3 (Ransum basal yang mengandung 15% tepung eceng gondok).Variabel yang diamati terdiri dari penentuan dan pengukuran kualitas interior telur meliputi indeks kuning telur, Haugh Unit (HU) dan warna kuning telur. Hasil penelitian menunjukkan pemberian ransum megandung tepung eceng gondok memberikan pengaruh terhadap warna kuning telur,namun tidak berpengaruh terhadap nilai indeks kuning telur dan Haugh Unit (HU).Pemberian tepung eceng gondok dapat digunakan sampai 15% dalam itik master
Формы организации историко-краеведческой деятельности студенческой молодежи Луганщины в 1991–2014 гг.: историко-педагогический аспект
Authors: Анпилогова Татьяна Юрьевна 
Published: July 2022

В процессе формирования гражданско-патриотической позиции современной молодежи значимое место занимает историко-краеведческая деятельность. Опыт ее организации в системе общеобразовательных учреждений и организаций дополнительного образования является предметом изучения многих ученых и педагогов-практиков. При этом процесс осуществления данного вида деятельности в высшей школе до сих пор остается малоизученным. Цель статьи – проанализировать формы историко-краеведческой деятельности студенческой молодежи в высших учебных заведениях Луганской области Украины в конце ХХ – начале XXI в. Автором выделены общегосударственные и региональные тенденции в развитии школьного и вузовского исторического образования; установлено, что в качестве основных видов деятельности по изучению истории родного края выступали усвоение теоретических знаний в ходе учебных занятий, научно-исследовательская работа, организация культурного досуга обучающихся.