bluuebunny/crossref_metadata_2025_split huggingface dataset:
L- Arginine and Lisinopril supplementation protects against sodium fluoride-induced nephrotoxicity and hypertension by suppressing mineralocorticoid receptor and angiotensin converting enzyme 3 activity
Authors: Ajibade Temitayo Olabisi , Awodele Olusola Adedayo , Tijani Monsuru Oladunjoye , Adejumobi Olumuyiwa Abiola , Adetona Moses Olusola , Oyagbemi Ademola Adetokunbo , Adedapo Aduragbenro Deborah , Omobowale Temitayo Olutayo , Aro Abimbola Obemisola , Ola-Davies Olufunke Eunice , Saba Adebowale Benard , Adedapo Adeolu Alex , Nkadimeng Sanah Malomile , McGaw Lyndy Joy , Kayoka-Kabongo Prudence Ngalula , Oguntibeju Oluwafemi Omoniyi , Yakubu Momoh Audu 
Published: August 2022

Abstract
Sodium fluoride (NaF) is one of the neglected environmental toxicants that has continued to silently cause toxicity to both humans and animals. NaF is universally present in water, soil and the atmosphere. The persistent and alarming rate of increase in cardiovascular and renal diseases and disorders caused by chemicals such as sodium fluoride (NaF) in mammalian tissues have led to the use of various drugs for the treatment of these diseases. This study aims at evaluating the renoprotective and antihypertensive effects of L- Arginine against NaF-induced nephrotoxicity. Thirty male Wistar rats (150–180 g) were used in this study. The rats were randomly divided into five groups of six rats each as Control, NaF (300 ppm), NaF + L- Arginine (100 mg/kg), NaF + L- Arginine (200 mg/kg), and NaF + Lisinopril (10 mg/kg), respectively; orally for eight days. Histopathological examination and immunohistochemistry of renal angiotensin converting enzyme (ACE) and mineralocorticoid receptor (MCR) were performed. Markers of renal damage, oxidative stress, antioxidant defence system, and blood pressure parameters were determined. L- Arginine and Lisinopril significantly (p < 0.05) ameliorated the hypertensive effects of NaF. The systolic, diastolic and mean arterial blood pressure of the treated groups were significantly (p < 0.05) reduced compared with the hypertensive group. This finding was concurrent with significantly increased serum bioavailability of nitric oxide in the hypertensive treated with and Lisinopril. Also, there was significant reduction in the level of blood urea nitrogen and creatinine in the serum of the hypertensive rats treated with L- arginine and Lisinopril. There was significant (p < 0.05) reduction in markers of oxidative stress such as malondialdehyde and protein carbonyl and concurrent increase in the levels of antioxidant enzymes in the kidney of hypertensive rats treated with L arginine and Lisinopril. The results of this study suggest that L- Arginine and and Lisinopril normalized high blood pressure, reduced oxidative stress, reduced the expression of renal angiotensin converting enzyme and mineralocorticoid receptor and improved nitric oxide production. Thus, L- Arginine holds promise as a potential therapy against hypertension and renal damage.
Effect of preheating during laser metal deposition on the properties of laminated bending dies
Authors: Joghan Hamed Dardaei , Hahn Marlon , Tekkaya A. Erman 
Published: August 2022

Abstract
Metal laminated tooling provides a fast and cheap manufacturing concept. In this study, laser metal deposition (LMD) is used for reducing and eliminating the stair step effect in a metal laminated bending die. A systematical analysis of the effect of preheating of the laminae on the surface quality and mechanical properties of the bending die is performed. Ferritic steel sheets (S355 MC) with a thickness of 2 mm are laser cut and stacked up to manufacture the laminated bending die with a radius of 6 mm. The sheets are joined and the stair steps are filled with LMD with stainless steel powder 316L-Si. The initial temperature of the tool sheets (substrates), beside room temperature, is elevated up to 300 °C. The effect of the preheating on the surface roughness, shape deviation, hardness, and residual stresses of the die are investigated. The mean height of the surface increases by 59% at elevated temperatures. However, the tensile residual stress parallel to the weld direction at the middle of the deposited area decreases only around 25%. The functionality of the forming tools manufactured by this method is proven by bending of DC06 and HC380LA sheets.
Rosiglitazone alleviates LPS-induced endometritis via suppression of TLR4-mediated NF-κB activation
Authors: Bao Hongchu , Qu Qinglan , Cong Jianxiang , He Shunzhi , Zhao Dongmei , Zhao Huishan , Yin Shuyuan , Ma Ding 
Published: August 2022

Abstract
Endometritis is a common reproductive system disease that seriously affects the reproductive health of women of childbearing age. Rosiglitazone (RGZ) is known to have anti-inflammatory and immunomodulatory effects. The effect of RGZ on the treatment of endometritis has not been reported. In the present study, we aimed to investigate the anti-inflammatory effect of RGZ on lipopolysaccharide (LPS)-induced endometritis and to explore its possible mechanism of action. Using LPS-induced endometritis mice as a model, the preventive and therapeutic effects of RGZ on endometrial inflammation were explored. Histopathology revealed that RGZ significantly attenuated LPS-induced endometritis in C57BL/6 mice. The anti-inflammatory effects of RGZ and possible related signaling pathways were investigated in vitro using human endometrial stromal cells (HESCs). The results of reverse transcription-polymerase chain reaction and western blot analysis showed that RGZ pretreatment could inhibit the expression of Toll-like receptor 4 (TLR4) and its downstream activation of nuclear factor-κB (NF-κB). Collectively, these results suggest that RGZ may inhibit LPS-induced endometritis through the TLR4-mediated NF-κB pathway.
Whole genome analysis of Enterobacter cloacae Rs-2 and screening of genes related to plant-growth promotion
Authors: Wang Xiaobo , Wu Zhansheng , Xiang Huichun , Zhu Shuangxi , Zhang Ziyan , Li Xueping , He Yanhui , Wang Jianwen 
Published: August 2022

Abstract
The genus Enterobacter is widely recognized for its biotechnology potential in improving soil environment and crop growth promoting. To further explore these biotechnological potentials, we sequenced and analyzed the whole genome of Enterobacter cloacae Rs-2. The analysis showed that the total length of Rs-2 genome was 6,965,070,514 bp, GC content was 55.80%; The annotation results of GO and COG databases showed that the genome contains a variety of growth-promoting genes, such as iscU, glnA, glnB (nitrogen fixation); iucABCD (siderophore synthesis) and fepA, fcuA, fhuA, and pfeA, etc. (siderophore transport); ipdC (secreted IAA) and gcd, pqqBCDEF (dissolved phosphorus), etc. The application of Rs-2 as a soil inoculant in the pot experiment increased the average fresh weight of radish shoots and roots by 65.76% and 71.60%, respectively, the length of roots increased by 68.33%, and the chlorophyll content in the leaves also increased effectively. In addition, the total phosphorus content of shoots and roots was increased by 20.0% and 32.8%, respectively. This study proved the plant growth-promoting ability of Rs-2 at the molecular level through genetic screening and analysis, which provided guidance for the further improvement of the strain, and laid a foundation for its application in agricultural production.
Effects of omega-3 supplementation as an adjunct to non-surgical periodontal therapy on periodontal parameters in chronic periodontitis patients: A randomized clinical trial
Authors: Maybodi Fahimeh Rashidi , Fakhari Mahsa , Tavakoli Fatemeh 
Published: August 2022

Abstract
Objectives: This study aimed to assess the effects of omega-3 fatty acid supplementation as an adjunct to non-surgical periodontal therapy on periodontal parameters in patients with chronic periodontitis (CP). Materials and Methods: This randomized clinical trial was conducted on 30 patients with moderate to severe generalized CP. All patients received standard non-surgical periodontal therapy, and were randomly divided into two groups of intervention and control (n=15). The intervention group was asked to use 1000 mg omega-3 soft-gels daily while the control group used placebo soft-gels for 3 months. Clinical attachment loss (CAL), probing depth (PD), and bleeding index (BI) were recorded at baseline (before the intervention) and after 3 months. The two groups were compared regarding the clinical parameters by t-test (alpha=0.05). Results: All three clinical parameters significantly decreased in both groups at 3 months compared with baseline (P=0.001). The improvement in PD and CAL in the intervention group was significantly greater than that in the control group (P=0.001); however, the difference in BI was not significant between the two groups (P=0.283). Conclusion: Omega-3 supplementation for 3 months as an adjunct to non-surgical periodontal therapy significantly improved the clinical parameters in CP patients.
ESG Ratings, Monetary Policy Uncertainty and Bond issuance Premium
Authors: Zhang Chunqiang , Gao Lu , Wang Wennbing , Hao Dayu , Wang Qinwen 
Published: August 2022

Abstract
Existing studies generally recognize the critical role played by macro monetary policy, of which the uncertainty will increase corporate bond issuance premiums at a micro level. However, relatively little is known about these relationships from the perspective of non-financial information in corporation. So this study set out to do further exploration. We use the database to obtain information, including the bond issuance of A-share listed corporations in China during 2015 to 2020. The findings suggest that high environmental, social, and governance (ESG) ratings from listed corporations significantly weaken the positive correlation between monetary policy uncertainty and bond issuance premiums. Specifically, it has a positive information pricing effect on China's primary debt issuance market, as well as a mitigating impact on macro financial policy risk. We also find, through further mechanistic studies, that ESG ratings are more helpful in undermining the impact of monetary policy uncertainty on bond issuance premiums in the context of higher financial information quality. Our findings are conducive to enriching the research framework of the economic consequences of ESG ratings, meaningfully influencing the growing literature that exposed the mechanism of bond issuance premiums, and further, verifying the interaction of information at different levels (macro vs micro) in asset pricing.
Neutrophil CD64 index as a superior indicator for monitoring bacterial infection and evaluating antibiotic therapy: a case control study
Authors: Gao Yanting , Lin Lihui , Zhao Jinyan , Peng Xia , Li Li 
Published: August 2022

Abstract
Background
Neutrophil CD64 (nCD64) index has been widely studied as an indication of bacteria-infected diseases, but the exact usage of nCD64 index in monitoring infections remains debated. So this study aims to investigate the functionality of nCD64 index in tracking infections’ progression and evaluating antibiotic therapy.
Methods
160 participants (36 healthy controls, 34 culture-negative patients, 56 respiratory tract infected patients, and 34 bloodstream infected patients) were recruited and divided into groups. Data on nCD64 index, T lymphocyte subsets, and conventional indicators, including white blood cell count, neutrophil to lymphocyte ratio, procalcitonin, and C-reactive protein, were tested and compared.
Results
Bacteria-infected patients had significantly higher nCD64 indexes (p < 0.05), especially patients with both bloodstream and respiratory tract infections. The nCD64 index could identify infected patients from culture-negative patients or controls, which conventional indicators cannot achieve. We followed up with 24 infected patients and found that their nCD64 indexes were promptly down-regulated after effective antibiotic therapy (3.16 ± 3.01 vs. 1.20 ± 1.47, p < 0.001).
Conclusions
The nCD64 index is a sensitive indicator for clinical diagnosis of bacterial infection, especially in monitoring infection and evaluating antibiotics’ efficacy. Therefore, nCD64 has the potential to improve diagnostic accuracy and provide rapid feedback on monitoring disease progression in infected patients.
Effect of fish downstream supply chain on wealth creation: the case of tambatinga in the Brazilian Midnorth
Authors: Gilson Florent , New Michael Bernard , Rodrigues Laurindo Andre , Valenti Wagner Cotroni 
Published: August 2022

Abstract
We describe the downstream supply and value chains originating from commercial tambatinga farming in Midnorth Brazil. We assessed how farm size affects intermediaries and job creation, income generation and the number of wealth beneficiaries. We surveyed 16 commercial farms from 0.1 to 220 ha and their supply chains. To compare wealth creation and the number of beneficiaries we established a baseline annual production of 550 t. Labor hours per tonne tended to rise in medium and extra-large farms. There were two main types of fish downstream supply chains: small farms selling their fish directly to consumers and large farms relying on intermediary trading, where gross revenue was spread among the different parts of the supply chain. Large supply chain stakeholders enhanced net income, typically through supermarket sales. However, the few farms and intermediaries involved resulted in low, poorly distributed, wealth creation. Intermediary trading through markets resulted in high global wealth creation but incomes below the minimum salary of most market sellers. Market sellers shipping from the wholesale market showed improved income. Fish trading undertaken by small farms produced the best gross revenue per traded fish, providing considerable wealth creation, especially in the case of selling at consumers’ homes and markets. This supply chain also permitted good wealth distribution. Net incomes of self-employed farmers exceeded the regional minimum salary by a factor of 3 to 5. Direct selling was thus more appropriate for lifting people out of poverty.
The efficacy of integrated hepatitis C virus treatment in relieving fatigue in people who inject drugs: A randomized controlled trial
Authors: Vold Jørn Henrik , Chalabianloo Fatemeh , Løberg Else-Marie , Aas Christer F. , Lim Aaron G. , Vickerman Peter , Johansson Kjell Arne , Fadnes Lars Thore 
Published: August 2022

Abstract
BackgroundMost people who inject drugs (PWIDs) suffer from severe fatigue, and chronic hepatitis C virus (HCV) infection may play a role in this. However, there is scarce evidence about interventions that alleviate fatigue among PWIDs. The present study investigated the effect of integrated HCV treatment on fatigue in this population compared to the effect of standard HCV treatment. MethodsThis multi-center, randomized controlled trial evaluated fatigue as a secondary outcome of integrated HCV treatment (the INTRO-HCV trial). From May 2017 to June 2019, 276 participants in Bergen and Stavanger, Norway, were randomly assigned to receive integrated and standard HCV treatment. Integrated treatment was delivered in eight decentralized outpatient opioid agonist therapy clinics and two community care centers; standard treatment was delivered in specialized infectious disease outpatient clinics at referral hospitals. Fatigue was assessed prior to treatment and 12 weeks after treatment using the nine-item Fatigue Severity Scale (FSS-9). We applied a linear mixed model to evaluate the impact of integrated HCV treatment on changes in FSS-9 (ΔFSS-9) sum scores.ResultsAt baseline, the mean FSS-9 sum score was 46 for participants on integrated HCV treatment and 41 for those on standard treatment. In the intention-to-treat analysis, integrated HCV treatment reduced the FSS-9 scores significantly better than standard treatment (ΔFSS-9: ­–2.7, 95% confidence interval (CI): –5.0;–0.4). No similar effect was found in the per-protocol analysis (ΔFSS-9: –1.0, 95% CI: –3.8;1.7). ConclusionFatigue is a common symptom among PWIDs. Integrated HCV treatment is superior, or at least equal to standard HCV treatment in improving fatigue. Trial registration: ClinicalTrials.gov.no NCT03155906, 16/05/2017.
Dual Privacy-Preserving Lightweight Navigation System for Vehicular Networks
Authors: Yao Yingying , Chang Xiaolin , Liu Jiqiang , Li Lin , Wang Hong 
Published: August 2022

Abstract
As an indispensable part of intelligent transportation system, a traffic-sensitive navigation system can assist drivers in avoiding traffic congestion by providing navigation services. The navigation service provider (NSP) utilizes road condition information from nearby vehicles collected by roadside units (RSUs) to guide a vehicle through an optimal route provided by the navigation services. This paper mainly focuses on tackling three key issues in such navigation system. Firstly, it is essential to ensure the privacy of the vehicles’ personal identifiable information (PII). Secondly, the location, start point destination and route of the vehicle should not be leaked to RSUs and also should not be linked to its PII by RSUs and NSP. Thirdly, the process of vehicles obtaining the navigation services should be lightweight. Because of such problems, this paper proposes a dual privacy-preserving lightweight navigation system for vehicular networks through designing a novel signature scheme and combining other cryptographic primitives to keep dual privacy including PII and route related information. And the correctness analysis of the proposed system, security proof of the designed signature scheme adopted in the proposed system, and privacy analysis of the system are thoroughly provided. In addition, the performance of the proposed system is evaluated and compared with the existing systems to illustrate that the proposed system is more efficient than the existing systems.
Gut microbiota alteration after cholecystectomy contributes to post-cholecystectomy diarrhea via bile acids stimulating colonic serotonin
Authors: Xu Ya-Yun , Wang Jianfa , Wu Xubo , Jing Hui , Zhang Shilong , Hu Zhiqiu , Rao Longhua , Chang Qimeng , Wang Li-Shun , Zhang Ziping 
Published: August 2022

Abstract
Post-cholecystectomy diarrhea (PCD) is highly prevalent among post-cholecystectomy outpatients and gut microbiota alteration is correlated with it. However, whether fecal bacteria alteration contributes to diarrhea are unrevealed. Herein, humanized gut microbiome mice model was established and PCD mice exhibited enhanced gastrointestinal motility and elevated fecal water content. In analyzing gut microbiota, tryptophan metabolism was enriched in PCD microbiome. Then, overabundant serotonin, along with elevated biosynthesis and reduced reuptake genes, and highly-expressed 5-HT receptors (5-HTR) in colon of PCD mice were found, but not in small intestine. Notably, diarrheal phenotypes in PCD mice were depleted by Tph1 inhibitor and 5-HTRs antagonists. Furthermore, increased PCD microbial secondary bile acids (BAs) metabolites of DCA, HDCA and LCA were revealed and were responsible for stimulating 5-HT. Intriguingly, blocking BAs-conjugated TGR5/TRPA1 signaling pathway alleviate PCD. Conclusively, altered gut microbiota after cholecystectomy induces PCD by promoting secondary BAs, which stimulates colonic 5-HT and increases colon motility.
Removing Unwanted Objects from Image/Frame By Generating Sub-Images Through Generative Adversarial Network
Authors: Choupani Roya , Doğan Hacer 
Published: August 2022

Abstract

The amazingly developing and advancing technology in every field also shows itself in image/frame processing. Today, computer vision is an important field of study that can be applied to computers with human vision. Generative networks have been used specifically in studies to specific purpose. After the generating networks were published, they were effectively used to obtain new data for various purposes. Basically, we aimed to remove an unwanted object on the picture or frame. With this aim, thought that like human vision, the foresight of the structures that will replace the object planned to be removed has been considered. Accordingly, if an object is in front of a structure/s the object to desired remove it, this possible data to replace the object must have a similar transitivity with the structure/s behind it. To do this, it is aimed to create new data by using sub-data in object location surrounding the object, with the approach that the appropriate data to replace the object can be filled by learning from the structures around the object. It was tried to replace the object (for pixels containing the object) by generating pixels in object dimensions, using generative networks and useful results were obtained, in this study.
The single cell transcriptional landscape of esophageal adenocarcinoma and its modulation by neoadjuvant chemotherapy
Authors: Croft Wayne , Evans Richard PT , Pearce Hayden , Elshafie Mona , Griffiths Ewen A , Moss Paul 
Published: August 2022

Abstract
Immune checkpoint blockade has recently proven effective in subsets of patients with esophageal adenocarcinoma (EAC) but little is known regarding the EAC immune microenvironment. We determined the single cell transcriptional profile of EAC in patients who were treatment-naive or had received neoadjuvant chemotherapy. Analysis of 52,387 cells revealed 10 major cell subsets of tumor, immune and stromal cells. Prior to chemotherapy tumors were heavy infiltrated by T regulatory cells and exhausted effector T cells whilst plasmacytoid dendritic cells were markedly expanded. Two dominant cancer-associated fibroblast populations were also observed whilst endothelial populations were suppressed. Pathological remission following chemotherapy associated with broad reversal of immune abnormalities together with fibroblast transition and an increase in endothelial cells whilst a chemoresistant epithelial stem cell population correlated with poor response. These findings reveal features that underlie and limit the response to current immunotherapy and identify a range of novel opportunities for targeted therapy.
Information about the natural history of acute infections commonly seen in primary care: a systematic review of clinical practice guidelines
Authors: Boaitey Kwame Peprah , Bakhit Mina , Krzyzaniak Natalia , Hoffmann Tammy 
Published: August 2022

Abstract
ObjectivesTo examine the reporting of natural history information, and relevant antibiotic stewardship strategies, in clinical guidelines for acute infections commonly seen in primary care and sometimes managed with antibiotics.MethodsA systematic review of national and international guidelines (2010 onwards), electronically available, for managing acute infections (respiratory, urinary, or skin and soft tissue). We searched MEDLINE, CINAHL, EMBASE, TRIP, and GIN databases and websites of 22 guideline-publishing organisations.ResultsWe identified 82 guidelines, covering 114 eligible infections. Natural history information was reported in 49 (59.8%) of the guidelines and 66 (57.9%) of the conditions, most commonly for respiratory tract infections. Quantitative information about the expected infection duration was provided for 63.5% (n = 42) of the infections. Delayed prescribing was recommended for 34.2% (n = 39) of them and shared decision making for 21% (n = 24).ConclusionsJust over half of the guidelines for acute infections that are commonly managed in primary care and often with antibiotics contained natural history information. As many of these infections spontaneously improve, this is a missed opportunity to disseminate this information to clinicians, promote antibiotic stewardship, and facilitate conversations with patients and informed decision-making.Systematic review registration: CRD42021247048