bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid and efficient characterization of cervical collagen orientation using linearly polarized colposcopic images
Authors: Khuong Cat Phan Ngoc , Quang Dung Nguyen Huu , Thanh Hai Pham , Nguyen Long , Ngoc Quynh Nguyen , Huynh Duc Le , Van Tien Tran , Anh Tu Ly 
Published: April 2022

Collagen provides tissue strength and structural integrity. Quantification of the orientated dispersion of collagen fibers is an important factor when studying the mechanical properties of the cervix. In this study, for the first time, a new method for rapid characterization of the collagen fiber orientations of the cervix using linearly polarized light colposcopy is presented. A total of 24 colposcopic images were captured using a cross-polarized imaging system with white LED light sources. In the preprocessing stage, the Red channel of the RGB image was chosen, which contains no information of the blood vessels because of the low-absorption of blood cells in the red region. OrientationJ, which is an ImageJ plug-in, was used to estimate the local orientation of the collagen fibers. The result shows that in the nonpregnant cervix, the middle zone (Zone 2) has circumferentially aligned collagen fibers while the inner zone (Zone 1) has randomly arranged. The collagen fiber dispersion in Zone 2 is much smaller than that in Zone 1 at all four quadrants region (anterior, posterior, left, and right quadrant). This new analysis technique could potentially combine with diagnostic tools to provide a quantitative platform of collagen fibers in the clinic.
Planning Wireless Backhaul Links by Testing Line of Sight and Fresnel Zone Clearance
Authors: Brown Philip E. , Czapiga Krystian , Jotshi Arun , Kanza Yaron , Kounev Velin , Suresh Poornima 
Published: April 2022

Microwave backhaul links are often used as wireless connections between telecommunication towers, in places where deploying optical fibers is impossible or too expensive. The relatively high frequency of microwaves increases their ability to transfer information at a high rate, but it also makes them susceptible to spatial obstructions and interference. Hence, when deploying wireless links, there are two conflicting considerations. First, the antennas height, selected from the available slots on each tower, should be as low as possible. Second, there should be a line of sight (LoS) between the antennas, and a buffer around the LoS defined by the first Fresnel zone should be clear of obstacles. To compute antenna heights, a planning system for wireless links has to maintain an elevation model, efficiently discover obstacles between towers, and execute Fresnel-zone clearance tests over a 3D model of the deployment area.
In this article we present a system and algorithms for computing the height of antennas, by testing LoS and clearance of Fresnel zones. The system handles the following requirements: (1) the need to cover large areas, e.g., all of the USA, (2) big distance between towers, e.g., 100 kilometers, and (3) computing batches of thousands of pairs within a few minutes. We introduce three novel algorithms for efficient computation of antenna heights, we show how to effectively model and manage the large-scale geospatial data needed for the planning, and we present the results of tests over real-world settings.
Metrics for Robot Proficiency Self-assessment and Communication of Proficiency in Human-robot Teams
Authors: Norton Adam , Admoni Henny , Crandall Jacob , Fitzgerald Tesca , Gautam Alvika , Goodrich Michael , Saretsky Amy , Scheutz Matthias , Simmons Reid , Steinfeld Aaron , Yanco Holly 
Published: April 2022

As development of robots with the ability to self-assess their proficiency for accomplishing tasks continues to grow, metrics are needed to evaluate the characteristics and performance of these robot systems and their interactions with humans. This proficiency-based human-robot interaction (HRI) use case can occur before, during, or after the performance of a task. This article presents a set of metrics for this use case, driven by a four-stage cyclical interaction flow: (1) robot self-assessment of proficiency (RSA), (2) robot communication of proficiency to the human (RCP), (3) human understanding of proficiency (HUP), and (4) robot perception of the human’s intentions, values, and assessments (RPH). This effort leverages work from related fields including explainability, transparency, and introspection, by repurposing metrics under the context of proficiency self-assessment. Considerations for temporal level (a priori, in situ, and post hoc) on the metrics are reviewed, as are the connections between metrics within or across stages in the proficiency-based interaction flow. This article provides a common framework and language for metrics to enhance the development and measurement of HRI in the field of proficiency self-assessment.
Tumor Immunogenomic Features Determine Outcomes in Patients with Metastatic Colorectal Cancer Treated with Standard-of-Care Combinations of Bevacizumab and Cetuximab
Authors: Innocenti Federico , Yazdani Akram , Rashid Naim , Qu Xueping , Ou Fang-Shu , Van Buren Scott , Bertagnolli Monica M. , Kabbarah Omar , Blanke Charles David , Venook Alan P. , Lenz Heinz-Josef , Vincent Benjamin G. 
Published: April 2022

Abstract

Purpose:
CALGB/SWOG 80405 was a randomized phase III trial in first-line patients with metastatic colorectal cancer treated with bevacizumab, cetuximab, or both, plus chemotherapy. We tested the effect of tumor immune features on overall survival (OS).

Experimental Design:
Primary tumors (N = 554) were profiled by RNA sequencing. Immune signatures of macrophages, lymphocytes, TGFβ, IFNγ, wound healing, and cytotoxicity were measured. CIBERSORTx scores of naive and memory B cells, plasma cells, CD8+ T cells, resting and activated memory CD4+ T cells, M0 and M2 macrophages, and activated mast cells were measured.

Results:
Increased M2 macrophage score [HR, 6.30; 95% confidence interval (CI), 3.0–12.15] and TGFβ signature expression (HR, 1.35; 95% CI, 1.05–1.77) were associated with shorter OS. Increased scores of plasma cells (HR, 0.55; 95% CI, 0.38–0.87) and activated memory CD4+ T cells (HR, 0.34; 95% CI, 0.16–0.65) were associated with longer OS. Using optimal cutoffs from these four features, patients were categorized as having either 4, 3, 2, or 0–1 beneficial features associated with longer OS, and the median (95% CI) OS decreased from 42.5 (35.8–47.8) to 31.0 (28.8–34.4), 25.2 (20.6–27.9), and 17.7 (13.5–20.4) months respectively (P = 3.48e–11).

Conclusions:
New immune features can be further evaluated to improve patient response. They provide the rationale for more effective immunotherapy strategies.
Phase I/II Multicenter Trial of a Novel Therapeutic Cancer Vaccine, HepaVac-101, for Hepatocellular Carcinoma
Authors: Löffler Markus W. , Gori Stefania , Izzo Francesco , Mayer-Mokler Andrea , Ascierto Paolo A. , Königsrainer Alfred , Ma Yuk Ting , Sangro Bruno , Francque Sven , Vonghia Luisa , Inno Alessandro , Avallone Antonio , Ludwig Jörg , Alcoba Diego Duarte , Flohr Christian , Aslan Katrin , Mendrzyk Regina , Schuster Heiko , Borrelli Marco , Valmori Danila , Chaumette Tanguy , Heidenreich Regina , Gouttefangeas Cécile , Forlani Greta , Tagliamonte Maria , Fusco Caterina , Penta Roberta , Iñarrairaegui Mercedes , Gnad-Vogt Ulrike , Reinhardt Carsten , Weinschenk Toni , Accolla Roberto S. , Singh-Jasuja Harpreet , Rammensee Hans-Georg , Buonaguro Luigi 
Published: April 2022

Abstract

Purpose:
Immunotherapy for hepatocellular carcinoma (HCC) shows considerable promise in improving clinical outcomes. HepaVac-101 represents a single-arm, first-in-human phase I/II multicenter cancer vaccine trial for HCC (NCT03203005). It combines multipeptide antigens (IMA970A) with the TLR7/8/RIG I agonist CV8102. IMA970A includes 5 HLA-A*24 and 7 HLA-A*02 as well as 4 HLA-DR restricted peptides selected after mass spectrometric identification in human HCC tissues or cell lines. CV8102 is an RNA-based immunostimulator inducing a balanced Th1/Th2 immune response.

Patients and Methods:
A total of 82 patients with very early- to intermediate-stage HCCs were enrolled and screened for suitable HLA haplotypes and 22 put on study treatment. This consisted in a single infusion of low-dose cyclophosphamide followed by nine intradermal coadministrations of IMA970A and CV8102. Only patients with no disease relapse after standard-of-care treatments were vaccinated. The primary endpoints of the HepaVac-101 clinical trial were safety, tolerability, and antigen-specific T-cell responses. Secondary or exploratory endpoints included additional immunologic parameters and survival endpoints.

Results:
The vaccination showed a good safety profile. Transient mild-to-moderate injection-site reactions were the most frequent IMA970A/CV8102-related side effects. Immune responses against ≥1 vaccinated HLA class I tumor-associated peptide (TAA) and ≥1 vaccinated HLA class II TAA were respectively induced in 37% and 53% of the vaccinees.

Conclusions:
Immunotherapy may provide a great improvement in treatment options for HCC. HepaVac-101 is a first-in-human clinical vaccine trial with multiple novel HLA class I– and class II–restricted TAAs against HCC. The results are initial evidence for the safety and immunogenicity of the vaccine. Further clinical evaluations are warranted.
A Phenogenetic Axis that Modulates Clinical Manifestation and Predicts Treatment Outcome in Primary Myeloid Neoplasms
Authors: Shen Qiujin , Feng Yahui , Gong Xiaowen , Jia Yujiao , Gao Qingyan , Jiao Xiaokang , Qi Saibing , Liu Xueou , Wei Hui , Huang Bingqing , Zhao Ningning , Song Xiaoqiang , Ma Yueshen , Liang Shihao , Zhang Donglei , Qin Li , Wang Ying , Qu Shiqiang , Zou Yao , Chen Yumei , Guo Ye , Yi Shuhua , An Gang , Jiao Zengtao , Zhang Song , Li Linfeng , Yan Jun , Wang Huijun , Song Zhen , Mi Yingchang , Qiu Lugui , Zhu Xiaofan , Wang Jianxiang , Xiao Zhijian , Chen Junren 
Published: April 2022

Although the concept of “myeloid neoplasm continuum” has long been proposed, few comparative genomics studies directly tested this hypothesis. Here we report a multi-modal data analysis of 730 consecutive newly diagnosed patients with primary myeloid neoplasm, along with 462 lymphoid neoplasm cases serving as the outgroup. Our study identified a “Pan-Myeloid Axis” along which patients, genes, and phenotypic features were all aligned in sequential order. Utilizing relational information of gene mutations along the Pan-Myeloid Axis improved prognostic accuracy for complete remission and overall survival in adult patients of de novo acute myeloid leukemia and for complete remission in adult patients of myelodysplastic syndromes with excess blasts. We submit that better understanding of the myeloid neoplasm continuum might shed light on how treatment should be tailored to individual diseases.Significance:The current criteria for disease diagnosis treat myeloid neoplasms as a group of distinct, separate diseases. This work provides genomics evidence for a “myeloid neoplasm continuum” and suggests that boundaries between myeloid neoplastic diseases are much more blurred than previously thought.
Prevention of Arterial Elastocalcinosis: Differential Roles of the Conserved Glutamic Acid and Serine Residues of Matrix Gla Protein
Authors: Parashar Abhinav , Bak Kyoungmi , Murshed Monzur 
Published: April 2022

Background:
Inactivating mutations in matrix Gla protein (MGP) lead to Keutel syndrome, a rare disease hallmarked by ectopic calcification of cartilage and vascular tissues. Although MGP acts as a strong inhibitor of arterial elastic lamina calcification (elastocalcinosis), its mode of action is unknown. Two sets of conserved residues undergoing posttranslational modifications—4 glutamic acid residues, which are γ-carboxylated by gamma-glutamyl carboxylase; and 3 serine residues, which are phosphorylated by yet unknown kinase(s)—are thought to be essential for MGP’s function.

Methods:

We pursued a genetic approach to study the roles of MGP’s conserved residues. First, a transgenic line (
SM22a-GlamutMgp
) expressing a mutant form of MGP, in which the conserved glutamic acid residues were mutated to alanine, was generated. The transgene was introduced to

Mgp
−/−

mice to generate a compound mutant, which produced the mutated MGP only in the vascular tissues. We generated a second mouse model (

Mgp
S3mut/S3mut

) to mutate MGP’s conserved serine residues to alanine. The initiation and progression of vascular calcification in these models were analyzed by alizarin red staining, histology, and micro-computed tomography imaging.

Results:

On a regular diet, the arterial walls in the

Mgp
−/−

;
SM22α-GlamutMgp
mice were not calcified. However, on a high phosphorus diet, these mice showed wide-spread arterial calcification. In contrast,

Mgp
S3mut/S3mut

mice on a regular diet recapitulated arterial calcification traits of

Mgp
−/−

mice, although with lesser severity.

Conclusions:
For the first time, we show here that MGP’s conserved serine residues are indispensable for its antimineralization function in the arterial tissues. Although the conserved glutamic acid residues are not essential for this function on a regular diet, they are needed to prevent phosphate-induced arterial elastocalcinosis.
The Ends of Capital: Terminal Crisis and the Substance of Value
Authors: Janzen David 
Published: April 2022

Abstract
Crisis is endemic to capitalism. But can it be proved that capitalism will bring about its own terminal crisis? This article frames this question in light of ongoing debates in theories of crisis and value by polemically comparing two related but divergent perspectives. The first, that of Robert Kurz and several Wertkritik authors, argues that cyclical crises of capital necessarily lead to a terminal crisis – and that this terminal crisis is already underway. The second, that of Michael Heinrich, argues that there is no way to demonstrate that capital will not continue reinventing new sites and forms for creating surplus value. Through this comparison, this article achieves two aims: first, it establishes the general point that how we understand value determines how we understand crisis; and, second, it shows limitations of the ‘terminal crisis’ hypothesis, and concludes that Kurz’s terminal crisis theory risks making crisis a transhistorical concept.
Thirteen-Centimeter Breast Lymphoma
Authors: Breese Rebecca O. , Friend Kara 
Published: April 2022

Lymphoma of the breast is a rare diagnosis, accounting for less than 0.5% of all breast malignancies. Presentation is usually similar to that of breast cancer, with a painless palpable mass. This report describes a unique case of a 13 cm breast lymphoma. The patient is a 74 year old female who presented to clinic with a right breast mass that has been present since the 1970s. She had previously undergone multiple excisions of lesions on both breasts, always with benign pathology. In 2017, screening mammogram revealed a suspicious lesion in the right upper outer breast with associated axillary lymphadenopathy. She was lost to follow up but presented again after the mass significantly grew in size over several months. Mammography showed a large 13 x 8.7 cm lobulated mass. Biopsy of the lesion revealed diffuse large B-cell lymphoma. Treatment for this patient will begin with chemotherapy.
Usability of a Human Factors-based Clinical Decision Support in the Emergency Department: Lessons Learned for Design and Implementation
Authors: Salwei Megan E. , Hoonakker Peter , Carayon Pascale , Wiegmann Douglas , Pulia Michael , Patterson Brian W. 
Published: April 2022

Objective To evaluate the usability and use of human factors (HF)–based clinical decision support (CDS) implemented in the emergency department (ED). Background Clinical decision support can improve patient safety; however, the acceptance and use of CDS has faced challenges. Following a human-centered design process, we designed a CDS to support pulmonary embolism (PE) diagnosis in the ED. We demonstrated high usability of the CDS during scenario-based usability testing. We implemented the HF-based CDS in one ED in December 2018. Method We conducted a survey of ED physicians to evaluate the usability and use of the HF-based CDS. We distributed the survey via Qualtrics, a web-based survey platform. We compared the computer system usability questionnaire scores of the CDS between those collected in the usability testing to use of the CDS in the real environment. We asked physicians about their acceptance and use of the CDS, barriers to using the CDS, and areas for improvement. Results Forty-seven physicians (56%) completed the survey. Physicians agreed that diagnosing PE is a major problem and risk scores can support the PE diagnostic process. Usability of the CDS was reported as high, both in the experimental setting and the real clinical setting. However, use of the CDS was low. We identified several barriers to the CDS use in the clinical environment, in particular a lack of workflow integration. Conclusion Design of CDS should be a continuous process and focus on the technology’s usability in the context of the broad work system and clinician workflow.
Trends and Gender Differences in Mental Disorders in Hospitalized Patients in Thailand
Authors: Suanrueang Passakorn , Peltzer Karl , Suen Mein-Woei , Lin Hsiao-Fang , Er Tze-Kiong 
Published: April 2022

Previous studies have shown that gender differences play a substantial role in the influence of mental disorders. This study was designed to investigate gender differences in mental disorders by presenting odd ratio (OR) trends and cumulative effects over a period of 13 years in Thailand. This observational study used hospital data from the Ministry of Public Health on selected patients admitted to inpatient departments in public hospitals with mental disorders, according to ICD-10 cause groups from 2007 to 2019, counting from more than 1,90,000 cases in 2007 to more than 4,00,000 cases in 2019. Data were collected from the Thailand Ministry of Public Health website. The results indicate that compared to women, men were positively related to five mental disorders revealed by the OR and the ratio per 100,000 population (mean and SD): psychoactive alcohol use (OR = 7.31-9.07, 271.19 (59.26)), substance abuse (OR = 5.06-7.82, 59.25 (33.71)), schizophrenia (OR = 1.64-1.93, 108.32 (19.62)), mental retardation (OR = 1.15-1.58, 10.64 (1.88)), and other mental and behavioral disorders (OR = 1.10-1.55, 70.67 (22.75)). Three mental disorders in men were found to be negatively related: neurotic and related disorders (OR=.34-.46, 27.98 (3.26)), mood (affective) disorders (OR = .44-.56, 31.91 (9.59)), and dementia (OR = .78-10.82, 13.75 (2.73)). Gender can become a key biological element that contributes to the dissimilarity of mental illness. Preventive care for men and women should, therefore, be prioritized for health conditions separately. More specifically, screening and detection, and providing appropriate intervention.
An improvement in clash detection process by prioritizing relevance clashes using fuzzy-AHP methods
Authors: Hasannejad Ali , Majrouhi Sardroud Javad , Shirzadi Javid Ali Akbar , Purrostam Towhid , Ramesht Mohammad Hasan 
Published: April 2022

Design coordination and clash detection are the most common and appreciated applications of three-dimensional modeling (3D modeling). In some projects, millions of clashes are detected including a large number of irrelevant clashes. The purpose of this research is to determine the priority of resolving clashes before the construction phase. In this research, the results of Autodesk Navisworks have been used to improve the process of clash detection. Also, this study attempts to use the fuzzy-AHP for weighting criteria and then, by presenting a relationship, to provide a basis to prioritizing clashes for their resolution and, finally, for identifying irrelevant clashes. This method has been tested on a real project, and the comparison of the expert opinions and the proposed method showed that applying the proposed relationship can identify important and irrelevant clashes. Practical application If clashes are not carefully detected in the design stage, project management components face a serious challenge. In this study, using the weight of clash elements and the degree of penetration of clash elements into each other, a logical and practical relationship is presented that improves the process of clash detection.
Minimum 2-Year Clinical Outcomes of Medial Meniscus Root Tears in Relation to Coronal Alignment
Authors: Ridley Taylor J. , Ruzbarsky Joseph J. , Dornan Grant J. , Woolson Thomas E. , Poulton Richard T. , LaPrade Robert F. , Provencher Matthew T. , Vidal Armando F. 
Published: April 2022

Background: The effect of coronal plane alignment on the outcomes of repairs of the medial meniscus root remains unclear. Hypothesis: Increased preoperative varus alignment is associated with higher failure rates and lower patient-reported outcomes (PROs) after isolated repair of the medial meniscus root. Study Design: Case series; Level of evidence, 4. Methods: Patients aged 18 years or older who underwent arthroscopy-assisted repair of the medial posterior meniscus root over a 7-year period were included. The mechanical axis of the knee was measured preoperatively. Osteoarthritis was assessed radiographically preoperatively and at the final follow-up according to the Kellgren-Lawrence grading scale. Failure was defined as any patient having to undergo revision root repair, partial meniscectomy of the previously repaired meniscus, debridement, lysis of adhesions, or conversion to arthroplasty. Results: A total of 53 patients (29 women, 24 men) with a mean age of 51.3 years were included in the follow-up analysis. The mean time of follow-up after surgery was 3.3 years (range, 22-77 months). Significant improvements were observed in all PROs analyzed. Decreased varus as measured by alignment percentage was correlated with baseline Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain ( P = .023) and WOMAC Stiffness ( P = .022). Alignment percentage was also significantly negatively correlated with postoperative WOMAC Stiffness ( P = .005) and positively correlated with Lysholm ( P = .003) and International Knee Documentation Committee ( P = .009) scores. Higher baseline Kellgren-Lawrence grade was correlated with worse postoperative PROs ( P < .05), except 12-Item Short Form Health Survey Mental Component Summary and satisfaction. Eight patients who underwent a concomitant high tibial osteotomy (HTO) achieved lower PROs in all scales analyzed, regardless of their alignment. When excluding patients who underwent HTO, postoperative Lysholm score ( P = .004) and postoperative WOMAC Stiffness (p = 0.014) were inferior among the patients with >5° of varus. Conclusion: Lower extremity alignment closest to neutral correlated with improved PROs. Patients who underwent a concurrent HTO had worse PROs than those who did not undergo HTO.