bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, Synthesis and Anticonvulsant Activity of New Phenoxyalkyl, Phenoxyethoxyethyl and Phenoxyacetyl Derivatives of Aminoalkanols
Authors: Pańczyk‐Straszak Katarzyna , Rapacz Anna , Marona Henryk , Żelaszczyk Dorota , Karczewska Elżbieta , Zając Martyna , Skiba‐Kurek Iwona , Siwek Agata , Waszkielewicz Anna 
Published: May 2022

AbstractForty new aminoalkanol derivatives with potential anticonvulsant activity were designed and synthesized. In vivo studies (mice, intraperitoneal administration) showed anticonvulsant activity (maximal electroshock seizure test, MES test) of nineteen compounds, (ED50 values and protective indices PI ranging 22.62–78.30 mg/kg b.w. and 1.78–4.25, respectively). Compounds 30 (R,S‐1‐((2‐(2‐(2‐chloro‐5‐methylphenoxy)ethoxy)ethyl)amino)propan‐2‐ol), 31 (R,S‐2‐((2‐(2‐(2‐chloro‐5‐methylphenoxy)ethoxy)ethyl)amino)propan‐1‐ol) and 33 (S enantiomer of 31) showed relatively low ED50 values (26.45–34.26 mg/kg b.w.) accompanied by PI indexes above 3. Compounds 30 and 31 were investigated in terms of mechanism of action (5‐HT1A receptors binding assay and in silico database screening) and safety against gastrointestinal flora (both compounds proved safe). An integral part of the study was also a comprehensive structure‐activity relationship, including current and previously obtained results for aminoalkanol derivatives.
A new method for the toughness assessment of mobile crane components based on damage mechanics
Authors: Li Dongsong , Könemann Markus , Dölz Michael , Münstermann Sebastian 
Published: May 2022

AbstractThe characterization of toughness properties in standard Charpy or fracture mechanics tests calls for thickness requirements to be met. Therefore, the characterization of toughness properties is a problem for thin‐walled structures. Replacing Charpy impact toughness testing by impact notch tensile testing can solve this problem. However, the toughness requirements are still expressed in terms of standard test results. Therefore, a framework is proposed here for translating these standard test requirements into impact notch tensile test requirements. The proposed framework relies on numerical simulations with a phenomenological damage mechanics model, which uses state‐of‐stress‐dependent, strain‐based criteria for the prediction of local damage and global fracture. This model takes the effects of non‐proportional strain paths into account and applies different criteria for cleavage and ductile fracture in order to predict correctly the activation of cleavage and ductile fracture mechanisms in the corresponding numerical simulations.
Accurate and timely diagnosis of Eosinophilic Esophagitis improves over time in Europe. An analysis of the EoE CONNECT Registry
Authors: Navarro Pilar , Laserna‐Mendieta Emilio J , Casabona Sergio , Savarino Edoardo , Pérez‐Fernández María Teresa , Ghisa Matteo , Pérez‐Martínez Isabel , Guagnozzi Danila , Perelló Antonia , Guardiola‐Arévalo Antonio , Racca Francesca , Betoré Elena , Blas‐Jhon Leonardo , Krarup Anne Lund , Martín‐Domínguez Verónica , Maniero Daria , Suárez Adolfo , Llerena‐Castro Ronald , de la Peña‐Negro Luisa , Navacerrada Alicia Granja , Pellegatta Gaia , Alcedo Javier , de Hurtado Mendoza‐Guena Lonore , Feo‐Ortega Sara , Barrio Jesús , Gutiérrez‐Junquera Carolina , Fernández‐Fernández Sonia , De la Riva Susana , E Navés Juan , Carrión Silvia , Ciriza de los Ríos Constanza , García‐Morales Natalia , Rodríguez‐Oballe Juan Armando , Dainese Raffaela , Rodríguez‐Sánchez Alba , Masiques‐Mas María Lluisa , Palomeque María Teresa , Santander Cecilio , Tamarit‐Sebastián Sonsoles , Arias Ángel , Lucendo Alfredo J 
Published: May 2022

AbstractBackgroundPoor adherence to clinical practice guidelines for eosinophilic esophagitis (EoE) has been described and the diagnostic delay of the disease continues to be unacceptable in many settings.ObjectiveTo analyze the impact of improved knowledge provided by the successive international clinical practice guidelines on reducing diagnostic delay and improving the diagnostic process for European patients with EoE.MethodsCross‐sectional analysis of the EoE CONNECT registry based on clinical practice. Time periods defined by the publication dates of four major sets of guidelines over 10 years were considered. Patients were grouped per time period according to date of symptom onset.ResultsData from 1,132 patients was analyzed and median (IQR) diagnostic delay in the whole series was 2.1 (0.7‐6.2) years. This gradually decreased over time with subsequent release of new guidelines (p < 0.001), from 12.7 years up to 2007 to 0.7 years after 2017. The proportion of patients with stricturing of mixed phenotypes at the point of EoE diagnosis also decreased over time (41.3% vs. 16%; p < 0.001), as did EREFS scores. The fibrotic sub‐score decreased from a median (IQR) of 2 (1‐2) to 0 (0‐1) when patients whose symptoms started up to 2007 and after 2017 were compared (p < 0.001). In parallel, symptoms measured with the Dysphagia Symptoms Score reduced significantly when patients with symptoms starting before 2007 and after 2012 were compared. A reduction in the number of endoscopies patients underwent before the one that achieved an EoE diagnosis, and the use of allergy testing as part of the diagnostic workout of EoE, also reduced significantly over time (p = 0.010 and p < 0.001, respectively).ConclusionThe diagnostic work‐up of EoE patients improved substantially over time at the European sites contributing to EoE CONNECT, with a dramatic reduction in diagnostic delay.
Variation in eastern wild turkey nesting phenology at their northern range limit
Authors: Gonnerman Matthew , A. Shea Stephanie , Sullivan Kelsey , Kamath Pauline , Blomberg Erik 
Published: May 2022

AbstractLimiting the potential for disturbance of wild turkey (Meleagris gallopavo) breeding and nesting is often stated as a concern for management, particularly when associated with the spring hunting season. The timing of wild turkey nesting has been shown to vary with latitude, with spring phenology, and among individuals, but local information on nesting timing is needed to fully evaluate local harvest regulations. Our objectives were to characterize wild turkey nesting phenology and identify overlap with current hunting season timing and hunter effort in Maine, USA. We also identified sources of variation related to land cover and individual female characteristics such as body condition and pathogen infection status. Finally, we compared the temporal distributions of nest initiation across the 2 years of our study. We assessed nesting phenology of eastern wild turkeys (M. g. silvestris) in Penobscot, Hancock, and Cumberland counties, Maine, by monitoring females for nesting activity using VHF and GPS transmitters. During April–July 2018 and 2019, we located 69 nests from radiomarked females and 3 nests from unmarked females. Of the nests discovered, 56 were presumed first attempts, 12 were second attempts, and one was a third attempt. The median date of nest initiation (i.e., date first egg was laid) for first nests was April 27 in 2018 and May 5 in 2019. Females that nested in areas with greater residential and urban development initiated nests earlier than females that used more rural agricultural land covers. Despite a delay in the onset of nesting in 2019, the distribution of nest initiation among females did not change throughout the season. Our results indicate that the majority of male harvest occurred concurrently with egg laying. Thus, current hunting season timing likely limits risks associated with disturbance of mating. Given that Maine's wild turkey population is thought to be stable or increasing, our data support maintaining the current hunting season structure. However, breeding and nesting phenology of wild turkeys should continue to be monitored in relation to changing environmental conditions, trends in the turkey population, hunter numbers, and spring harvest, so that future changes can be incorporated into harvest management and decision making.
Landscapes and Landforms of the Chobe Enclave, Northern Botswana
Authors: Mokatse Thuto , Diaz Nathalie , Shemang Elisha , Van Thuyne John , Vittoz Pascal , Vennemann Torsten , Verrecchia Eric P. 
Published: May 2022

Abstract
The northern part of the ChobeEnclave (an administrative district of northern Botswana) is an agricultural area situated between relatively pristine national parks situated in the Middle Kalahari Basin. It belongs to the Linyanti-Chobe structural basin and constitutes a syntectonic depocenter formed within a large structural depression, known as the Okavango Graben, a tectonic structure of a likely trans-tensional nature. The landscape includes fossil landforms, such as sanddunes, pans, sand ridges, and carbonate islands resulting from palaeo-environmental and palaeo-drainage changes through the Quaternary and associated to (neo)tectonic processes. In addition to river- and wind-reworked Kalahari sands, the sediments include diatomites and carbonate deposits, forming inverted reliefs and originating from palustrine palaeo-environments. The Linyanti-Chobebasin is at the convergence of several ecoregions from tropical and subtropical grasslands to savannasand shrublandbiomes. The hydrological cycle in the northern ChobeEnclave is governed by a complex interplay between the Okavango, Kwando, and Upper Zambezidrainagebasins, which originate from tropical watersheds of the Angolan highlands. Finally, the widespread development of termite mounds impacts the diversity of soils and sediments of the northern ChobeEnclave, which is also reflected in the vegetation.
Adding flavor to the Narain ensemble
Authors: Datta Shouvik , Duary Sarthak , Kraus Per , Maity Pronobesh , Maloney Alexander 
Published: May 2022

Abstract
We revisit the proposal that the ensemble average over free boson CFTs in two dimensions — parameterized by Narain’s moduli space — is dual to an exotic theory of gravity in three dimensions dubbed U(1) gravity. We consider flavored partition functions, where the usual genus g partition function is weighted by Wilson lines coupled to the conserved U(1) currents of these theories. These flavored partition functions obey a heat equation which relates deformations of the Riemann surface moduli to those of the chemical potentials which measure these U(1) charges. This allows us to derive a Siegel-Weil formula which computes the average of these flavored partition functions. The result takes the form of a “sum over geometries”, albeit with modifications relative to the unflavored case.
Off-shell cubic hypermultiplet couplings to $$ \mathcal{N} $$ = 2 higher spin gauge superfields
Authors: Buchbinder Ioseph , Ivanov Evgeny , Zaigraev Nikita 
Published: May 2022

Abstract
We construct manifestly 4D, $$ \mathcal{N} $$
N
= 2 supersymmetric and gauge invariant off-shell cubic couplings of matter hypermultiplets to the higher integer spin gauge $$ \mathcal{N} $$
N
= 2 multiplets introduced in arXiv:2109.07639. The hypermultiplet is described by an analytic harmonic 4D, $$ \mathcal{N} $$
N
= 2 superfield q+ with the physical component spins $$ \mathbf{s}=\left(\frac{1}{2},0\right) $$
s
=

1
2

0

and an infinite number of auxiliary fields. The cubic coupling constructed has the schematic structure $$ {q}^{+}{\hat{\mathrm{\mathscr{H}}}}_{(s)}^{++}{q}^{+} $$

q
+

ℋ
̂

s

+
+

q
+

, where $$ {\hat{\mathrm{\mathscr{H}}}}_{(s)}^{++} $$

ℋ
̂

s

+
+

is a differential analytic operator of the highest degree (s− 1) accommodating the massless gauge $$ \mathcal{N} $$
N
= 2 multiplet with the highest spin s. For odd s the gauge group generators and couplings are proportional to U(1)PG generator of the internal SU(2)PG symmetry of the hypermultiplet and so do not exist if SU(2)PG is unbroken. If this U(1)PG is identified with the central charge of 4D, $$ \mathcal{N} $$
N
= 2 supersymmetry, a mass for the hypermultiplet is generated and the odd s couplings vanish in the proper massless limit. For even s the higher-spin gauge transformations and cubic superfield couplings can be defined for both massive and massless (central-charge neutral) hypermultiplets without including U(1)PG generator. All these features directly extend to the case of n hypermultiplets with the maximal internal symmetry USp(2n) × SU(2).
Approximation Properties of the Sampling Kantorovich Operators: Regularization, Saturation, Inverse Results and Favard Classes in $$L^p$$-Spaces
Authors: Costarelli Danilo , Vinti Gianluca 
Published: May 2022

AbstractIn the present paper, a characterization of the Favard classes for the sampling Kantorovich operators based upon bandlimited kernels has been established. In order to achieve the above result, a wide preliminary study has been necessary. First, suitable high order asymptotic type theorems in$$L^p$$Lp-setting,$$1 \le p \le +\infty $$1≤p≤+∞, have been proved. Then, the regularization properties of the sampling Kantorovich operators have been investigated. Here, we show how the regularity of the kernel influences the operator itself; this has been shown for bandlimited kernels, or more in general for kernels in Sobolev spaces, satisfying a Strang-Fix type condition of order$$r \in \mathbb {N}^+$$r∈N+. Further, for the order of approximation of the sampling Kantorovich operators, quantitative estimates based on the$$L^p$$Lpmodulus of smoothness of orderrhave been established. As a consequence, the qualitative order of approximation is also derived assumingfin suitable Lipschitz and generalized Lipschitz classes. Moreover, an inverse theorem of approximation has been stated, allowing to obtain a full characterization of the Lipschitz and of the generalized Lipschitz classes in terms of convergence of the above sampling type series. These approximation results have been proved for not necessarily bandlimited kernels. From the above mentioned characterization, it remains uncovered the saturation case that, however, can be treated by a totally different approach assuming that the kernel is bandlimited. Indeed, since sampling Kantorovich (discrete) operators based upon bandlimited kernels can be viewed as double-singular integrals, exploiting the properties of the convolution in Fourier Analysis, we become able to get the desired result obtaining a complete overview of the approximation properties in$$L^p(\mathbb {R})$$Lp(R),$$1 \le p \le +\infty $$1≤p≤+∞, for the sampling Kantorovich operators.
The scent gland chemistry of Gagrellinae (Opiliones, Sclerosomatidae): evidence for sequestration of myrmicacin in a species of Prionostemma
Authors: Raspotnig Günther , Bodner Michaela , Blesl Julia , Viquez Carlos 
Published: May 2022

AbstractThe scent gland secretion of an undetermined species of Prionostemma from Costa Rica was analyzed by gas chromatography–mass spectrometry and shown to consist of medium-chain carboxylic acids (mainly octanoic acid) and a ß-hydroxy-carboxylic acid, eventually identified as myrmicacin (= (R)-3-hydroxydecanoic acid). While scent gland secretions in harvestmen have traditionally been considered to be products of de novo synthesis, we here provide evidence for the unusual case of sequestration-derived scent gland constituents: at least myrmicacin appears to be sequestered from leaf-cutter ants that constitute a part of the prey of the Prionostemma-species herein investigated. This is the first report on the scent gland chemistry of the sclerosomatid subfamily Gagrellinae as well as on a possible sequestration mechanism in harvestmen.
Detrital zircon ages from Archaean conglomerates in the Singhbhum Craton, eastern India: implications on economic Au-U potential
Authors: Frimmel Hartwig E. , Chakravarti Rajarshi , Basei Miguel A. S. 
Published: May 2022

Abstract
New U–Pb age and Hf isotope data obtained on detrital zircon grains from Au- and U-bearing Archaean quartz-pebble conglomerates in the Singhbhum Craton, eastern India, specifically the Upper Iron Ore Group in the Badampahar Greenstone Belt and the Phuljhari Formation below the Dhanjori Group provide insights into the zircon provenance and maximum age of sediment deposition. The most concordant, least disturbed 207Pb/206Pb ages cover the entire range of known magmatic and higher grade metamorphic events in the craton from 3.48 to 3.06 Ga and show a broad maximum between 3.38 and 3.18 Ga. This overlap is also mimicked by Lu–Hf isotope analyses, which returned a wide range in εHf(t) values from + 6 to − 5, in agreement with the range known from zircon grains in igneous and metamorphic rocks in the Singhbhum Craton. A smaller but distinct age peak centred at 3.06 Ga corresponds to the age of the last major magmatic intrusive event, the emplacement of the Mayurbhanj Granite and associated gabbro, picrite and anorthosite. Thus, these intrusive rocks must form a basement rather than being intrusive into the studied conglomerates as previously interpreted. The corresponding detrital zircon grains all have a subchondritic Hf isotopic composition. The youngest reliable zircon ages of 3.03 Ga in the case of the basal Upper Iron Ore Group in the east of the craton and 3.00 Ga for the Phuljhari Formation set an upper limit on the age of conglomerate sedimentation. Previously published detrital zircon age data from similarly Au-bearing conglomerates in the Mahagiri Quartzite in the Upper Iron Ore Group in the south of the craton gave a somewhat younger maximum age of sedimentation of 2.91 Ga. There, the lower limit on sedimentation is given by an intrusive relationship with a c. 2.8 Ga granite. The time window thus defined for conglomerate deposition on the Singhbhum Craton is almost identical to the age span established for the, in places, Au- and U-rich conglomerates in the Kaapvaal Craton of South Africa: the 2.98–2.78 Ga Dominion Group and Witwatersrand Supergroup in South Africa. Since the recognition of first major concentration of gold on Earth’s surface by microbial activity having taken place at around 2.9 Ga, independent of the nature of the hinterland, the above similarity in age substantially increases the potential for discovering Witwatersrand-type gold and/or uranium deposits on the Singhbhum Craton. Further age constraints are needed there, however, to distinguish between supposedly less fertile (with respect to Au) > 2.9 Ga and more fertile < 2.9 Ga successions.
Organizing the fragmented landscape of multidisciplinary product development: a mapping of approaches, processes, methods and tools from the scientific literature
Authors: Guérineau Julia , Bricogne Matthieu , Rivest Louis , Durupt Alexandre 
Published: May 2022

AbstractThe fourth industrial revolution is shaping a new industrial landscape. A variety of technologies related to software, information and communication technologies embody a ubiquitous digital and connectivity era. These technologies enable the creation of new products with the integration of connectivity, data collection and processing capacities which require combining engineering disciplines. Increasing product multidisciplinarity compels companies to adapt their product development practices. The scientific literature offers a variety of concepts and techniques to support multidisciplinary product development. This paper seeks to organize the landscape of concepts and techniques available for multidisciplinary product development. An extensive literature review was conducted, and 236 concepts and techniques were identified. Multidisciplinary products of interest deal with both software and hardware development and can be encountered through the denominations of cyber-physical systems, mechatronics and smart products and systems. An in-depth analysis led to the classification and mapping, for each product denomination, of the concepts and techniques available to support their development. The classification relies on a four-level model paired with a decision tree to thoroughly sort the variety of concepts and techniques into the approach, process, method, and tool levels. The mapping between the sorted concepts and techniques enabled the generation of graphical representations called cartographies. These cartographies serve to support companies’ transformation towards the fourth industrial revolution from the product development perspective by giving a general overview of the related literature, and guiding them in the identification of the most suitable approaches, processes, methods and tools.
The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro
Authors: Merches Katja , Breunig Leonie , Fender Julia , Brand Theresa , Bätz Vanessa , Idel Svenja , Kollipara Laxmikanth , Reinders Yvonne , Sickmann Albert , Mally Angela , Lorenz Kristina 
Published: May 2022

AbstractRemdesivir is a prodrug of a nucleoside analog and the first antiviral therapeutic approved for coronavirus disease. Recent cardiac safety concerns and reports on remdesivir-related acute kidney injury call for a better characterization of remdesivir toxicity and understanding of the underlying mechanisms. Here, we performed an in vitro toxicity assessment of remdesivir around clinically relevant concentrations (Cmax 9 µM) using H9c2 rat cardiomyoblasts, neonatal mouse cardiomyocytes (NMCM), rat NRK-52E and human RPTEC/TERT1 cells as cell models for the assessment of cardiotoxicity or nephrotoxicity, respectively. Due to the known potential of nucleoside analogs for the induction of mitochondrial toxicity, we assessed mitochondrial function in response to remdesivir treatment, early proteomic changes in NMCM and RPTEC/TERT1 cells and the contractile function of NMCM. Short-term treatments (24 h) of H9c2 and NRK-52E cells with remdesivir adversely affected cell viability by inhibition of proliferation as determined by significantly decreased 3H-thymidine uptake. Mitochondrial toxicity of remdesivir (1.6–3.1 µM) in cardiac cells was evident by a significant decrease in oxygen consumption, a collapse of mitochondrial membrane potential and an increase in lactate secretion after a 24–48-h treatment. This was supported by early proteomic changes of respiratory chain proteins and intermediate filaments that are typically involved in mitochondrial reorganization. Functionally, an impedance-based analysis showed that remdesivir (6.25 µM) affected the beat rate and contractility of NMCM. In conclusion, we identified adverse effects of remdesivir in cardiac and kidney cells at clinically relevant concentrations, suggesting a careful evaluation of therapeutic use in patients at risk for cardiovascular or kidney disease.
Rapid high-throughput compatible label-free virus particle quantification method based on time-resolved luminescence
Authors: Kopra Kari , Hassan Nazia , Vuorinen Emmiliisa , Valtonen Salla , Mahran Randa , Habib Huda , Jalkanen Pinja , Susi Petri , Hytönen Vesa , Hankaniemi Minna , Ylä-Herttuala Seppo , Kakkola Laura , Peurla Markus , Härmä Harri 
Published: May 2022

AbstractViruses play a major role in modern society and create risks from global pandemics and bioterrorism to challenges in agriculture. Virus infectivity assays and genome copy number determination methods are often used to obtain information on virus preparations used in diagnostics and vaccine development. However, these methods do not provide information on virus particle count. Current methods to measure the number of viral particles are often cumbersome and require highly purified virus preparations and expensive instrumentation. To tackle these problems, we developed a simple and cost-effective time-resolved luminescence-based method for virus particle quantification. This mix-and-measure technique is based on the recognition of the virus particles by an external Eu3+-peptide probe, providing results on virus count in minutes. The method enables the detection of non-enveloped and enveloped viruses, having over tenfold higher detectability for enveloped, dynamic range from 5E6 to 3E10 vp/mL, than non-enveloped viruses. Multiple non-enveloped and enveloped viruses were used to demonstrate the functionality and robustness of the Protein-Probe method.
Graphical abstract