bluuebunny/crossref_metadata_2025_split huggingface dataset:
Usage Pattern and Practices of Antibiotics’ Self-Medication among Healthcare Practitioners
Authors: Iqbal Muhammad Shahid , Khan Salah-ud-Din 
Published: March 2022

Objective: The study aimed to evaluate the usage pattern and current practices of antibiotics’ self-medication among HCPs.
Methods: A cross-sectional study was done using a validated research tool to obtain the required data. Data was obtained using different questions regarding self-medication and usage pattern of antibiotics among HCPs. Descriptive and inferential statistics were applied using the Statistical Package for Social Sciences (SPSS) version 24.0. A p-value < 0.05 was considered statistically significant.
Results: Different demographic characteristics were studied from the selected cohort of the HCPs. Around 153 (52.9%) of the studied HCPs were females and 136 (47.1%) were males. The studied HCPs were of different professions, whereby 53 (18.3%) from medicine, 103 (35.6%) from pharmacy, 13 (4.45%) from dentistry, 98 (33.9%) from nursing, and 22 (7.6%) from others allied professions.
Conclusion: From the obtained results, it was concluded that all of the studied HCPs had diverse usage pattern and practices towards antibiotics’ usage pattern but still there is a greater need to strictly adhere with and follow the recommended and concerned guidelines regarding antibiotics usage to avoid any unwanted side effects, adverse drug reactions and antibiotic resistance.
Anti Microbial Activity of Musa sapientum Mediated Copper Nanoparticle against Oral Pathogens: An In-vitro Study
Authors: Yazhlini P. , Ganesh S. Balaji , Rajeshkumar S. 
Published: March 2022

Background: Musa sapientum is a useful medicinal plant from the Musaceae family. Copper nanoparticles with a high surface to volume ratio can also be used as antifungal and antibacterial agents. The aim of the study is to access the antimicrobial activity of musa sapientum mediated copper nanoparticle against oral pathogens
Materials and Methods: Plant extract was prepared by 1g of musa, was weighed aseptically and then dissolved in 100 ml of distilled water. Then the solution is boiled for about 5 minutes at a temperature of about 60-80 degree Celsius and then allowed to cool down followed by filtration of extract. The copper solution was prepared by dissolving 20 millimolar of copper sulphate in 80 ml of distilled water followed by 20 ml of plant extract and then the mixture is placed in the shaker for the synthesis and then allowed to mix for about 1 hour then the first reading was taken using UV spectrum and noted down. Antimicrobial activity was done against the strain of S. aureus, S. mutans, E. faecalis. Muller Hinton agar was utilised for this activity to determine the zone of inhibition different concentrations were loaded in the plates and incubated for 24 hrs 37 degree celsius after the incubation time the zone of inhibition was measured. Antifungal activity of zinc oxide nanoparticles was done against the strain Candida Albicans.
Results: For the study, descriptive statistics was used. For 100 μL concentration 11 mm zone of inhibition was seen when compared to the standard drug Amoxyrite which had a zone of inhibition of 36mm, which means that the antimicrobial activity was low in case of E. Faecalis. In C. Albicans, at 100μL concentration 14mm zone of inhibition was seen, but the standard fluconazole had only a zone of inhibition of 10mm, which means antimicrobial activity was good in case of C. albicans which showed more zone of inhibition. For S. aureus, at 100μL 13mm zone of inhibition was seen, the standard value showed 28mm zone of inhibition which means there is less zone of inhibition when compared to standard drug. For S. mutans, at 100μL concentration 18mm zone of inhibition was seen and when compared to the standard value which was 23mm which showed poor antimicrobial activity.
Conclusion: The research concludes that musa sapientum mediated copper nanoparticles showed a moderate antimicrobial activity against the pathogens Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis and Candida albicans.
Screening of Antibacterial Activity from Mangrove Plants (Rhizophora mucronata) Leaf Associated Actinobacterium of Streptomyces Species
Authors: Francis John , Arivarasu Lakshminarayanan , Sivaperumal Pitchiah , Thangavelu Lakshmi 
Published: March 2022

Introduction: Mangrove is a shrub or small tree that grows in coastal saline water mostly. The term is also used for tropical coastal vegetation consisting of special species. Mangroves occur worldwide mostly in the tropics and subtropics, mainly between latitudes 25° N and 25° S. The total mangrove forest area of the world was 137,800 square kilometres spanning 118 countries and territories
Materials and Methods: The fresh leaves of were collected from Pichavaram area, Tamilnadu. The leaves were washed thoroughly with tap water then surface sterilized with 1% of hydrogen peroxide. Then the sample was macerated in mortar and pestle.
Results and Discussion: The antibacterial activity of the rhizophora extract was analysed using two types of assays, namely disc diffusion method and Minimum Inhibitory Concentration (MIC) assay. The disc diffusion test was done for different concentrations for the selected clinical isolates (Klebsiella, streptococcus and vibrio ).
Conclusion: From this study ,we can conclude that has good antibacterial activity against these microorganisms (Klebsiella, streptococcus and vibrio) and further studies can be done in future.
To Study Abo Blood Group Correlation with Pain Pressure Threshold and Tolerance, Core Stability in Young Healthy Individuals
Authors: Agarwal Tanvi , Raghav Deepak , Dwivedi Amit 
Published: March 2022

Background: The term “blood type” refers to the antigen phenotype, which is the serologic expression of the inherited blood group genes, such as A, B, and O in the ABO system.
Physical fitness as an important factor in assessing a person's physical health and motor ability consists of various components such as core endurance and strength. Pain pressure threshold is determined as the duration of time between the subject’s first reported pain and exposure to the painful stimulus or the minimum force applied to induce pain.
Methodology: Healthy male and female volunteers within the age range of 18–25 years were recruited for this co-relational study based on inclusion and exclusion criteria. The study consisted of one experimental session in which a questionnaire was filled out, a blood type test was performed, and two rounds of pressure pain thresholds (PPTs) over the core muscles i.e. over Rectus Abdominis, Transverse Abdominis, Multifidus and Erector Spinae were obtained separated by a cold pressor test (CPT). The session lasted 30 min. The study was approved by the ethical committee of Santosh University, Ghaziabad and conducted within the timeline of May-august 2021 at the Department of physiotherapy, Santosh hospital, Ghaziabad, U.P. T- test, Anova and Karl Pearson correlation method were used to analyze the data.
Results: Result showed that both core stability and pain tolerance had significant difference and association among different blood groups (p>0.05). Also blood group O had the least mechanical sensitivity as it had the highest pain tolerance ( mean ± SD= 56.48 ± 37.39) after CPT test. Also B+ has the good core stability as compared with means (mean ± SD= 48.50 ± 27.44) of other blood groups.
Conclusion: Study concluded that there was significance association among different ABO blood groups and pain tolerance in healthy young Indian individuals which showed evidence that blood groups can be incorporated in physical therapy assessment and management.
In-vitro Antioxidant and Antidiabetic Properties of Corchorus olitorius Leaves and Seed Ethanol Extract
Authors: Britina . , Sridevi G. , Selvaraj J. 
Published: March 2022

Background: Medicinal herbs have been widely used in therapeutic applications for various diseases in today’s world. These herbs are used by village folk medicine, but without scientific evidence. Corchorus olitorius, also known as jute mallow is a herb that possesses many curing effects like pain, fever and many other diseases like cystitis and tumour etc.
Objective: The objective of the study was to elucidate the effects of corchorus olitorius as antioxidant and antidiabetic.
Materials and Methods: In Vitro Evaluation of antidiabetic and antioxidant properties were conducted using various tests. Alpha - amylase inhibitory activity and alpha glucosidase inhibitory activity for antidiabetic activity and DPPH free radical scavenging assay for antioxidant property was performed. The results were compared with standard metformin and aspirin respectively.
Results: Results showed a dose dependent increase in alpha amylase inhibitory activity with concentration ranging from 100-500 micro/ml.
Results showed a dose dependent increase in alpha glucosidase inhibitory activity with concentration ranging from 100-500 micro/ml.
Results showed a dose dependent increase in DPPH free radical scavenging activity with concentration ranging from 100-500 micro/ml.
Conclusion: The results showed an innovative finding that ethanolic seed extract of corchorus olitorius has great potential as antidiabetic and antioxidant property which can be used as novel innovative natural medication in the medical field rather than using any artificial synthetic drug which causes many other side-effects like allopathic drugs.
Assessment of Diagnostic Accuracy of IOTA - ADNEX Model in Detecting the Risk of Malignancy in Ovarian Carcinomas
Authors: Srinidhi Cherukuri , Jajoo Shubhada S. 
Published: March 2022

Background: Ovarian cancer has become a major public health issue which stood in 10th rank of mortality within India. 2.4 % is the annual new cases of ovarian cancer in overall India. In 2008 it was the seventh leading cause of cancer deaths in women worldwide. 70% of cases are diagnosed with poor prognosis at an advanced stage. Ovarian malignancy death rate is of 70% within 2 yrs and 90% within five years. It’s a tough task for a gynecologist to identify ovarian cancer correctly .Ovarian malignancy is initially detected as adnexal mass. Exploratory laparotomy or laparoscopy with histopathology is a specific diagnostic procedure for adnexal mass. This study aims to study and analyse the diagnostic accuracy of IOTA - ADNEX model in detecting the risk of malignancy in ovarian carcinomas.
Objectives: To make pre-operative diagnosis of adnexal masses and conserve the in menstruating women with less aggressive management.
Methodology: This prospective study will be conducted in Obstetrics & Gynaecology department of AVBRH, Wardha from September 2020 to July 2022. This will be conducted on 50 females presenting with adnexal mass. Patients will undergo transvaginal ultrasonography with HERA W10 ultra sound system with an endovaginal EA2-11B probe. The ultra sound evaluation we will include IOTA –ADNEX Model. The mass with the most complex structure will be chosen for analysis for ultrasound imaging to know the chances of being malignant.
Expected Results: Positive correlation between the IOTA –ADNEX model and histopathological report.
Conclusion: IOTA-ADNEX model to be incorporated for ovarian malignancy diagnostic protocol.
Intestinal Invaginations in Adults
Authors: Acar Hasan Zafer , Akalin Arkin 
Published: March 2022

Intestinal invaginations in adults are rare phenomenon . The most critical etiological causes are malignancies. The most common symptoms are abdominal pain, nausea, vomiting, inability to pass flatus and defecation, and distention in the abdomen due to intestinal obstruction. On physical examination, abdominal distention, decreased bowel sounds and sometimes a mass may be palpable on deep palpation.
In direct radiography, air-liquid levels can be seen. A mass can be detected in the invagination area on ultrasonography. Definitive diagnosis is usually made by computerized tomography.
Treatment of intestinal invaginations in adults is usually surgery. It can be done by laparoscopic or open surgery.
As a result, we think that when a definitive diagnosis is made in adults, intestinal invagination should be treated surgically under oncological principles since the etiological factor is mostly malignancy.
Prevalence of Job-Related Injuries among Construction Workers in Eastern Region, Saudi Arabia
Authors: Naeem Abdulrahman Al , O’Rourke Mary Kay , Harber Phillip , Humphrey Kyle , Abugad Hassan , Otaibi Sultan T. Al , Alnaim Muna Faisal 
Published: March 2022

The aim of the study was to detect the prevalence of work-related Musculoskeletal Injuries among construction workers, to evaluate injury-related sick leave, and identify factors contributing to injury.
the study was conducted and distributed to Saudi construction companies in three cities in the eastern region and 201 workers were approached and 149 were enrolled in the study. Jobs were categorized based on level of impact and jobs with similar levels were grouped together. Multiple Regression was used to evaluate stress categories and a cluster analysis was run on scaled and normalized types of stress and pain to identify factors closely associated with sick days taken. The results showed a response rate of 74.1%. A univariate analysis was used, and it demonstrated a 75.2% pain in upper and lower extremities, 61.7% pain was reported in upper extremities (Shoulder and Neck > Wrists and Hands > Elbow) and 12.8% pain reported in lower extremities (Lower back > Hips > Knees). In conclusion, the prevalence of work-related MSI in this large construction company was 75.2%. stratified multiple regression suggests job categories are good predictors of physical stress exposure and sick leave taken, also, the amount of force exerted, and vibration experienced by workers is closely linked to sick leave taken as well. Medium and high pain levels were linked to keyboard work, pushing / pulling, lifting and use of vibrating tools these workers would benefit from training emphasizing ergonomics and an explanation of proper techniques to handle tools. Lastly, applying new engineering controls would be helpful in the prevention of injuries that can minimize sick leave.
Comparative Study of Bio Feedback Training with Strengthening Exercises vs Strengthening Exercises in Osteoarthritis Knee Cases
Authors: Rana Pritika , Senthil P. , Alagappan T. , Subramanian Shenbaga Sundaram , Neelam N.  Shazia , Haribabu L. 
Published: March 2022

Introduction: Osteoarthritis is a non-inflammatory degenerative disorder of joints causing disability in millions of people all over the world. WHO estimates that 10% of world’s population over 60 years of age suffers from osteoarthritis and 80% of people with osteoarthritis have limitation of movement and 25% are unable to do daily activities. Thus, making it a major cause of impairment & disability in elderly and economic burden in community.
The purpose of the study is to compare the effects of biofeedback training along with strengthening exercises vs strengthening exercises in knee osteoarthritis subjects to reduce the symptoms of pain, loss of ROM and functional activity.
Methods: 50 subjects diagnosed of grade-I to early grade-II osteoarthritis recruited for the studyafter obtaining an Informed consent. Each group will comprise of 25 subjects with age group ranging 40-70 years. Group A will be given biofeedback training along with the strengthening exercises of knee, Group B will be given strengthening exercises exclusively. Both the groups will undergo training for 3 days per week for 6 weeks. Each session will be of 20-30 minutes.
Results: Parameters include WOMAC score and joint ROM, both pre-test and post-test measures will be analyzed statistically using t-test to check the effectiveness of each technique. P-value WOMAC Score showed p>0.0001 and shows significance in the biofeedback training subjects.
Conclusion: In this study bio feedback training with the strengthening exercises shows significant improvement in quadriceps muscle strength, increase Range of Motion in knee joint and reduction in other symptoms of OA knee.
Effects of Statin Drugs on New Onset of Diabetes Mellitus in Post Menopausal Women
Authors: Laghari Muhammad Jamil , Memon Fazeela Rizwan , Memon Sadat , Memon Rizwan Ahmed , Sattar Abdul , Bhatti Muhammad Ishaque , Shams Salman 
Published: March 2022

Background: Statin drugs are using all over the world for the treatment of hypercholesterolemia. There is hypothesis that post menopausal women who used statin drugs long time can develop the onset of type 2 diabetes mellitus because statin drugs inhibit the signal transduction of insulin by inhibiting oxidative phosphorylation resulting in decrease secretion of insulin leads to hyperglycemia. The aim of this study to estimate the effects of statin drugs on blood glucose level and HbA!c% in post menopausal women.
Methodology: This case comparative study was done at LUMHS Jamshoro. The sampling was done by Non Probability method. Total number of150 subjects were divided in 2 group’s i.e group A (Control group) & group B (Case study group). The fasting glucose level was measured by glucose oxidase method while HbA1c% & serum cholesterol levels were determined by Kit method by using auto analyzer. The statistical analysis was done by SPSS 21 by applying ANOVA test for multiple variants.
Results: The mean with S.D fasting blood glucose levels in control group was 78± 9.05 mg/dl while in case study group it was 134 ± 12.15mg/dl (p <0.05), HbA1c% levels in control group was 5.3 ± 1.1% while in case study group it was 7.4 ± 1.3% (p<0.05) and serum cholesterol in control group was 157± 9.75 mg/dl while in case study group it was 195 ± 8.78 mg/dl (p<0.05) was significantly (P<0.05). The glycemic index & fasting blood glucose levels significantly observed elevated in post menopausal women who were use statin drugs since last three years
Conclusion: This study concluded that there was significant relation of statin drugs on increasing of blood glucose levels so they can induce the onset of Type-2 Diabetes Mellitus.
Role of Moderate Risk Suseptibilty Genes in Development of Breast Cancer
Authors: Abbas Kouser , Sami Amtul , Batool Ufaque , Shaikh Ubedullah 
Published: March 2022

Breast cancer is the most common cause of mortality in females globally and affects the lives of millions of women. It is a leading cause of mortality worldwide, but the dynamics have been changed because of advanced screening and treatment protocols [1]. In the United States, breast cancer has been ranked second most common cause of cancer-related death in women, with the most common being lung cancer [2]. To improve cancer screening, a personalized approach has been discussed, but its implication over large populations can be difficult and require expertise. Early detection leads to a good prognosis whereas the late diagnosis of breast cancer is a challenge for both patient and doctor [3]. Breast cancer became the most prevalently diagnosed cancer worldwide as of 2021 accounting for 12% of new annual cases worldwide, according to the World Health Organization. In2020, there were 2.3 million women diagnosed with breast cancer and 685 000 deaths globally. Multigene panel testing has identified various genes predisposed to breast cancer development. These genes have different penetrance abilities. BRCA1 and BRCA2 genes are the best known high penetrance gene of hereditary breast cancer. Their discovery has revolutionized the effect in cancer assessment. Tumors from BRCA1 and BRCA2 show distinctive clinicopathological characteristics as compared with other genes causing tumors. Beyond BRCA1 and BRCA2, advances in molecular technique have led to the identification of other genes associated with breast cancer. Some other the high penetrance genes are TP53, PTEN, STK11, and CDH1. Besides high pentrance gene, moderate to low penetrance genes are also recognized as a cancer predisposing genes: PALB, BRIP1, ATM, CHEK2, BARD1, NBN, NF1, RAD51C, RAD51D. Along with risk of breast cancer development these genes also predispose to other malignancies, as well as some genetic disorders.
Schistosoma mansoni no Maranhão entre 1997 e 2019: uma prospecção tecnológica e científica
Authors: Lima Cleiane Dias , Andrade Dallyla Souza de , Moreira Gleidiany da Costa , Lima Clanecy Alves Soares , Sousa Ângelo Afonso Ferreira , Sousa Raimundo Leilton Santos , Leal Antonia de Sousa , Rêgo Nayra da Costa Silva , Rocha Jefferson Almeida 
Published: March 2022

A esquistossomose é uma doença parasitária que tem o homem como hospedeiro definitivo e comum em locais sem saneamento básico. Esta pesquisa tem o objetivo de realizar uma prospecção científica e tecnológica sobre a esquistossomose no Estado do Maranhão. A prospecção tecnológica foi realizada por meio da busca nas bases: EPO, USPTO, INPI e DII, e por busca em artigos científicos nas bases: Scielo, Bireme, PubMed, Web of Science, Scopus e Science Direct, de 1997 até 2019. Os resultados para patentes mostraram que a base USPTO obteve o maior número de publicações, com 1.879 registros. Nos resultados para prospecção científica, observa-se que para o descritor “Schistosoma mansoni” a base Bireme lidera com 8.063 e para o "Schistosoma mansoni" and "Maranhão" diminui para 21 artigos. Dessa forma, percebe-se que é necessário mais incentivo e investimentos para a realização de mais pesquisas relacionadas à esquistossomose, isso devido ao seu impacto na saúde pública e os poucos tratamentos quimioterápicos encontrados.
Atomic Short‐Range Order in a Cation‐Deficient Perovskite Anode for Fast‐Charging and Long‐Life Lithium‐Ion Batteries
Authors: Yang Liting , Xiong Xuhui , Liang Guisheng , Li Xiao , Wang Chao , You Wenbin , Zhao Xuebing , Liu Xianhu , Che Renchao 
Published: March 2022

AbstractPerovskite‐type oxides are widely used for energy conversion and storage, but their rate‐inhibiting phase transition and large volume change hinder the applications of most perovskite‐type oxides for high‐rate electrochemical energy storage. Here, it is shown that a cation‐deficient perovskite CeNb3O9 (CNO) can store a sufficient amount of lithium at a high charge/discharge rate, even when the sizes of the synthesized particles are on the order of micrometers. At 60 C (15 A g−1), corresponding to a 1 min charge, the CNO anode delivers over 52.8% of its capacity. In addition, the CNO anode material exhibits 96.6% capacity retention after 2000 charge–discharge cycles at 50 C (12.5 A g−1), indicating exceptional long‐term cycling stability at high rates. The excellent cycling performance is attributed to the formation of atomic short‐range order, which significantly prevents local and long‐range structural rearrangements, stabilizing the host structure and being responsible for the small volume evolution. Moreover, the extremely high rate capacity can be explained by the intrinsically large interstitial sites in multiple directions, intercalation pseudocapacitance, atomic short‐range order, and cation‐vacancy‐enhanced 3D‐conduction networks for lithium ions. These structural characteristics and mechanisms can be used to design advanced perovskite electrode materials for fast‐charging and long‐life lithium‐ion batteries.