bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Interactivity in Live Video Experiences Reduces Loneliness
Authors: Kaveladze Benjamin T. , Morris Robert R. , Dimitrova-Gammeltoft Rosa Victoria , Goldenberg Amit , Gross James J. , Antin Judd , Sandgren Melissa , Thomas-Hunt Melissa C. 
Published: March 2022

BackgroundLoneliness, especially when chronic, can substantially reduce one's quality of life. However, positive social experiences might help to break cycles of loneliness by promoting more prosocial cognitions and behaviors. Internet-mediated live video communication platforms (eg Zoom and Twitch) may offer an engaging and accessible medium to deliver such social experiences to people at scale. Despite these platforms' widespread use, there is a lack of research into how their socially interactive elements affect users' feelings of loneliness and connection.ObjectiveWe aimed to experimentally evaluate whether socially interactivity in live video experience improves loneliness-related outcomes.Materials and MethodsWe recruited participants from an online survey recruitment platform and assigned half to participate in a socially interactive live video experience with 6–12 strangers and the other half to a non-interactive control experience that was designed to be identical in every way but not socially interactive. Participants completed several baseline self-report measures of psychosocial wellbeing, participated in the hour-long video experience (an entertaining astronomy lesson), and then completed some baseline measures again. Four weeks later, we followed up with participants to evaluate their change in trait loneliness since baseline. We Pre-registered our hypotheses and analysis plan and provide our data, analysis code, and study materials online.ResultsTwo hundred and forty-nine participants completed the initial study and met inclusion criteria, 199 of whom also completed the 4-week follow-up. Consistent with our predictions, we found that directly after the more socially interactive experience, participants' feelings of connectedness increased more (p &lt; 0.001), positive affect increased more (p = 0.002), feelings of loneliness decreased more (p &lt; 0.001), social threat decreased more (p = 0.006), and negative affect decreased more (p = 0.003) than they did after the less interactive experience. However, change in trait loneliness between baseline and 4 weeks later did not differ between conditions (p = 0.953).ConclusionsIncluding socially interactive components in live video experiences can improve loneliness-related psychosocial outcomes for a short time. Future work should explore leveraging these benefits toward longer-term prosociality. Future work can also identify if the effects we observed generalize across different populations and kinds of online experiences.
Submarine Landslide Susceptibility Mapping in Recently Deglaciated Terrain, Glacier Bay, Alaska
Authors: Avdievitch Nikita N. , Coe Jeffrey A. 
Published: March 2022

Submarine mass wasting events have damaged underwater structures and propagated waves that have inundated towns and affected human populations in nearby coastal areas. Susceptibility to submarine landslides can be pronounced in degrading cryospheric environments, where existing glaciers can provide high volumes of sediment, while cycles of glaciation and ice-loss can damage and destabilize slopes. Despite their contribution to potential tsunami hazard, submarine landslides can be difficult to study because of limited access and data collection in underwater environments. Here we present a method to quantify and map the submarine landslide susceptibility of sediment-covered slopes in Glacier Bay, Glacier Bay National Park and Preserve, Alaska, using multibeam-sonar bathymetric digital elevation models (DEMs) and historical maps of glacial extents over the last ∼250 years. After mapping an inventory of &gt;7,000 landslide scarps in submarine sediments, we filtered the inventory by size to account for limitations in DEM resolution and spatial scales relevant to tsunami hazards. We then assessed landslide concentration, accounting for the age of the initial exposure of submarine slopes by deglaciation. We found a positive correlation between landslide concentration and deglaciation age, which we interpreted as a mean landslide accumulation rate over the period of record. Local deviations from this rate indicated differences in susceptibility. Additionally, we accounted for some of the effect of material and morphometric properties by estimating the submarine bedrock-sediment distribution using a morphometric model and assessing the relationship between slope angle and landslide incidence. Finally, we supplemented our susceptibility assessment with a geomorphic component based on the propensity of active submarine fans and deltas to produce landslides. Thus, our map of submarine landslide susceptibility incorporates three components: age-adjusted landslide concentration, slope angle, and geomorphology. We find that areas of mapped high susceptibility correlate broadly with areas of high sediment input and availability, locations of fans and deltas, and steep sediment-covered glacially carved fjords and troughs. Areas of high submarine landslide susceptibility in Glacier Bay moderately correspond with locations of known high-hazard subaerial slopes, but more research on submarine and subaerial landslides in degrading cryospheric environments would be beneficial to better understand landslide and tsunami hazards.
Spatio-Temporal Patterns of Carbon Storage Derived Using the InVEST Model in Heilongjiang Province, Northeast China
Authors: Li Xiaoying , Huang Chensheng , Jin Huijun , Han Yilun , Kang Siqi , Liu Jing , Cai Huiying , Hu Tongxin , Yang Guang , Yu Hongzhou , Sun Long 
Published: March 2022

Carbon storage is an important component of ecosystem services. Under climate warming and human activities, land use/land cover (LULC) have been undergoing tremendous change, leading to spatio-temporal variations in carbon storage. Based on seven series of LULC data and combined with carbon module of Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model, spatial-temporal changes in LULC types and carbon storage were analyzed and estimated for Heilongjiang Province, Northeast China. Results show varied carbon storage among different types of LULC. Forest and cropland are the dominant LULC types in Heilongjiang Province, Northeast China, accounting for 46–49% (20.90 × 104–22.12 × 104km2) and 30–37% (13.56 × 104–16.70 × 104km2) of the total area. Areal extents of forest, grassland, and unused land declined from 1980 to 2015, by 1.22, 0.84, and 1.11 × 104km2, respectively; while those of cropland and construction land expanded, by 3.14 and 0.08 × 104km2, respectively. From 1980 to 2015, carbon storage displayed consistent change trends with those of LULC types: carbon storage of forest, grassland, and unused land decreased by 236.22, 116.61 and 21.82 × 106 Mg C, respectively; and those of cropland and construction land increased by 414.65 and 0.99 × 106 Mg C, respectively. The total carbon storage in the study region was 6,863.06 × 106–6,907.64 × 106 Mg C, for which the forest, cropland, and grassland were the major contributor (6,778.75 × 106–6,840.57 × 106 Mg C). Due to the conversion of large extents of forest, grassland, and unused land to cropland, which facilitated the formation of carbon sinks and thus enlarged the carbon storage by 45.36 × 106 Mg C from 1980 to 2015. Frequent forest fires, urban expansion, farmland reclamation, and engineering construction were the important factors of changes in the LULC, accelerating permafrost degradation and leading to obvious changes in the total carbon storage in the Heilongjiang Province, Northeast China. Therefore, the estimation of carbon storage in different LULC types can provide important data support and have important implications for evaluation of ecosystem services and carbon cycle.
Perspectives of Care Experienced Young People Regarding Their Academic Experiences in Further Education
Authors: Howard Kirstie , MacQuarrie Sarah 
Published: March 2022

BackgroundThe academic attainment of care experienced young people (CEYP) is consistently reported as below the national average. Studies emphasize associations between low academic attainment and poor life outcomes. Most research relating to CEYP and education, has highlighted the impact of educational barriers and opportunities on their progression and subsequent attainment. Although, this research is almost exclusively concerned with schooling up to aged 16. Few studies have explored the perspectives and experiences of CEYP in further education, especially in a Scottish context.AimThis study aimed to centralize the views of CEYP to gain insight into the perceived achievement opportunities and barriers in FE. Secondly, this study aimed to consider CEYP experiences in FE to inform support services for CEYP.SampleTen CEYP, aged 16–24, studying at a further education college in Scotland participated in the study. Seven further education colleges from geographically diverse regions are represented.MethodsCEYP participated in semi-structured interviews to share their experience of further education.FindingsThematic analysis was used to produce the following main themes: Care experience and personal narratives, valuing further education and navigating support systems.ConclusionThese findings provide unique insight into CEYP experiences of FE. Opportunities for CEYP achievement in FE included stability of education and accommodation, personalized and financial support and supportive relationships. Reported barriers included care-related challenges, additional support needs (ASN), staff knowledge and labeling practices. Priorities for support service development included increased CEYP informed and led services such as peer mentoring, corporate parenting training and peer education. Implications for FE practice and future research are discussed. A summary of key points for consideration are provided in theSupplementary Materialand may be of particular interest to any educational organisation in a corporate parenting role.
Integration of Metabolomics and Proteomics in Exploring the Endothelial Dysfunction Mechanism Induced by Serum Exosomes From Diabetic Retinopathy and Diabetic Nephropathy Patients
Authors: Yang Jing , Liu Dongwei , Liu Zhangsuo 
Published: March 2022

BackgroundThe prevalence of diabetic microvascular diseases has increased significantly worldwide, the most common of which are diabetic nephropathy (DN) and diabetic retinopathy (DR). Microvascular endothelial cells are thought to be major targets of hyperglycemic damage, while the underlying mechanism of diffuse endothelial dysfunction in multiple organs needs to be further investigated.AimThe aim of this study is to explore the endothelial dysfunction mechanisms of serum exosomes (SExos) extracted from DR and DN (DRDN) patients.MethodsIn this study, human glomerular endothelial cells (HGECs) were used as the cell model. Metabolomics ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and proteomics tandem mass tag (TMT)-based liquid chromatography-tandem mass spectrometry (LC-MS/MS) together with bioinformatics, the correlation analysis, and the joint pathway analysis were employed to discover the underlying mechanisms of endothelial dysfunction caused by patient’s SExos.ResultsIt can be assumed that serum exosomes extracted by DRDN patients might cause endothelial dysfunction mainly by upregulating alpha subunit of the coagulation factor fibrinogen (FIBA) and downregulating 1-methylhistidine (1-MH). Bioinformatics analysis pointed to an important role in reducing excess cysteine and methionine metabolism.ConclusionFIBA overexpression and 1-MH loss may be linked to the pathogenicity of diabetic endothelial dysfunction in DR/DN, implying that a cohort study is needed to further investigate the role of FIBA and 1-MH in the development of DN and DR, as well as the related pathways between the two proteins.
Association Between Abdominal Adipose Tissue Distribution and Obstructive Sleep Apnea in Chinese Obese Patients
Authors: Ma Bingwei , Li Yingying , Wang Xingchun , Du Lei , Wang Shilin , Ma Huihui , Zhou Donglei , Usman Taofeek , Lu Liesheng , Qu Shen 
Published: March 2022

PurposeFactors related to the occurrence of obstructive sleep apnea syndrome (OSAS) in obesity have not been fully clarified. The aim of this study was to identify the association between OSAS and abdominal fat distribution in a cohort of Chinese obese patients.MethodsThis cross-sectional study collected demographic data of 122 obese patients who were admitted into the in-patient unit of the Department of Endocrinology, Shanghai Tenth People’s Hospital from July 2018 to January 2021. OSAS was diagnosed based on the results of overnight polysomnography, and the abdominal fat distribution was measured by bioelectrical impedance analysis (BIA). Univariate and multivariate logistic regression analyses were used to investigate the association between OSAS and the distribution of abdominal fat.Results(1) The mean age (SD) of the obese patients included was 32.44 (11.81) years old, and the overall incidence rate of OSAS was 51.06%. Twenty-four (25.53%) patients had mild OSAS, 10 (10.64%) had moderate OSAS, and 14 (14.89%) had severe OSAS. The apnea hypopnea index (AHI) of men was significantly higher than that of women (5.50, interquartile range (IQR) 3.80–30.6 vs. 4.2, IQR 1.4–12 events/h, p = 0.014). Meanwhile, men had a significantly higher visceral fat area when compared with women (180.29 ± 51.64 vs. 143.88 ± 53.42 cm2, p = 0.002). (2) Patients with OSAS had a significantly higher waist circumference, fasting plasma glucose, 2 h postprandial plasma glucose, glycated hemoglobin, and visceral fat area than patients without OSAS (all p &lt; 0.05). (3) AHI was significantly positively associated with BMI, neck circumference, waist circumference, and visceral fat area (r = 0.306, p = 0.003; r = 0.380, p &lt; 0.001; r = 0.328, p = 0.002; r = 0.420, p &lt; 0.001) but not with subcutaneous fat area (p = 0.094). Multivariate analysis demonstrated that abdominal fat area and fasting plasma glucose were independent risk factors for OSAS (odds ratio, 1.016; 95% confidence interval, 1.005–1,026, p = 0.005; odds ratio, 1.618; 95% confidence interval, 1.149–2.278, p = 0.006).ConclusionsIn obese patients, the abdominal visceral adipose deposit but not the subcutaneous fat area was associated with OSAS and was an independent risk factor for OSAS. Therefore, improving the distribution of abdominal fat may contribute to alleviating the severity of OSAS in obesity.
Techno-Economic Evaluation of Biological and Fluidised-Bed Based Methanation Process Chains for Grid-Ready Biomethane Production
Authors: Gantenbein Andreas , Kröcher Oliver , Biollaz Serge M. A. , Schildhauer Tilman J. 
Published: March 2022

Three different power-to-methane process chains with grid injection in two scales (1 MWel and 6 MWel) were analysed regarding their investment and operation cost. The process chains were based on biological or catalytic bubbling fluidised bed methanation in combination with proton exchange membrane or solid oxide electrolyser cells. A bottom-up techno-economic analysis showed a cost benefit of around 17–19% lower biomethane production cost for the bubbling fluidised bed technology as less than a third of the reactor volumes is required for catalytic methanation. This cost benefit is only given in combination with PEM electrolysis, as the high-temperature electrolyser stacks currently result in high investment cost. Based on electricity cost of 5 €-ct/kWhel and a plant size of 6 MWel, biomethane production cost of 13.95 €-ct./kWh for catalytic and 17.30 €-ct/kWh for biological methanation could be obtained, both including PEM electrolysis. A significant efficiency increase by integrating the heat of catalytic methanation reaction with the high-temperature electrolysis can be achieved; however investment cost have to decrease below 1000 €/kWel to obtain economically feasible production cost of biomethane. Under current economic and technological circumstances, CO2 methanation using the bubbling fluidised bed technology is the most cost effective.
Are the Agro-Ecosystems Sustainable? Measurement and Evaluation: A Case Study of Sichuan Province, China
Authors: Dai Xiaowen , Chen Yi , Wu Xin , He Yanqiu , Wang Fang 
Published: March 2022

In recent years, with the frequent occurrence of global climate problems, China has paid great attention to sustainable development and ecological environment governance. Sichuan Province is a significant grain production and a reserve base in western China, and its sustainable development in agriculture is an important foundation for the healthy development of the regional agricultural economy and food security. In this study, we divided the agricultural production land in Sichuan into cultivated land, water area, grassland, and forest land. We used the ecological footprint method to investigate the ecological footprint and the carrying capacity of agriculture in Sichuan comprehensively. We conclude that 1) generally, the overall agricultural ecosystem in Sichuan has been in a state of ecological surplus for the past 20 y, and the environmental pressure is gradually decreasing. However, the development within the ecosystem is uneven. 2) In terms of subdivision, the cultivated land, forest land, and water area in Sichuan have always been in a state of ecological surplus, but the grassland is in an ecological deficit state. In terms of the trend, the ecological status of cultivated land has declined significantly, while the forest land has gradually improved, and the water area is relatively stable. Yet, the deficit of grassland is still severe. 3) Forest land is considered the most sustainable type and has a high resource utilization rate all the time, followed by water area, cultivated land, and grassland, when measured by ecological indicators. At the same time, in terms of the coordination between economy and ecology, all lands have been improved.
Case Report: A Paternal 20q13.2-q13.32 Deletion Patient With Growth Retardation Improved by Growth Hormone
Authors: Liu Yu , Yang Ying , Chu Liming , Ren Shuai , Li Ying , Gao Aimin , Wen Jing , Deng Wanling , Lu Yan , Kong Lingyin , Liang Bo , Shao Xiaoshan 
Published: March 2022

Interstitial chromosome 20q deletions, containing GNAS imprinted locus, are rarely reported in the past. Hereby, we presented a Chinese boy with a novel 4.36 Mb deletion at paternal 20q13.2-13.32, showing feeding difficulty, malnutrition, short stature, lower limb asymmetry, sightly abnormal facial appearance and mild intellectual abnormality. With 3 years’ growth hormone treatment, his height was increased from 90 to 113.5 cm. This report is the first time to describe the outcome of clinical treatment on a patient with this rare chromosomal 20 long arm interstitial deletion, containing GNAS locus, which may facilitate the diagnosis and treatment of this type of patient in the future.
A Neurometabolic Pattern of Elevated Myo-Inositol in Children Who Are HIV-Exposed and Uninfected: A South African Birth Cohort Study
Authors: Bertran-Cobo Cesc , Wedderburn Catherine J. , Robertson Frances C. , Subramoney Sivenesi , Narr Katherine L. , Joshi Shantanu H. , Roos Annerine , Rehman Andrea M. , Hoffman Nadia , Zar Heather J. , Stein Dan J. , Donald Kirsten A. 
Published: March 2022

IntroductionExposure to maternal HIV in pregnancy may be a risk factor for impaired child neurodevelopment during the first years of life. Altered neurometabolites have been associated with HIV exposure in older children and may help explain the mechanisms underlying this risk. For the first time, we explored neurometabolic profiles of children who are HIV-exposed and uninfected (CHEU) compared to children who are HIV-unexposed (CHU) at 2-3 years of age.MethodsThe South African Drakenstein Child Health Study enrolled women during pregnancy and is following mother-child pairs through childhood. MRI scans were acquired on a sub-group of children at 2-3 years. We used single voxel magnetic resonance spectroscopy to measure brain metabolite ratios to total creatine in the parietal grey matter, and left and right parietal white matter of 83 children (36 CHEU; 47 CHU). Using factor analysis, we explored brain metabolite patterns in predefined parietal voxels in these groups using logistic regression models. Differences in relative concentrations of individual metabolites (n-acetyl-aspartate, myo-inositol, total choline, and glutamate) to total creatine between CHEU and CHU groups were also examined.ResultsFactor analysis revealed four different metabolite patterns, each one characterized by covarying ratios of a single metabolite in parietal grey and white matter. The cross-regional pattern dominated by myo-inositol, a marker for glial reactivity and inflammation, was associated with HIV exposure status (OR 1.63; 95% CI 1.11–2.50) which held after adjusting for child age, sex, and maternal alcohol use during pregnancy (OR 1.59; 95% CI 1.07 –2.47). Additionally, higher relative concentrations of myo-inositol to total creatine were found in left and right parietal white matter of CHEU compared to CHU (p=0.025 and p=0.001 respectively).DiscussionIncreased ratios of myo-inositol to total creatine in parietal brain regions at age 2-3 years in CHEU are suggestive of early and ongoing neuroinflammatory processes. Altered relative concentrations of neurometabolites were found predominantly in the white matter, which is sensitive to neuroinflammation, and may contribute to developmental risk in this population. Future work on the trajectory of myo-inositol over time in CHEU, alongside markers of neurocognitive development, and the potential for specific neurodevelopmental interventions will be useful.