bluuebunny/crossref_metadata_2025_split huggingface dataset:
Superficial angiomyxoma of the breast in a 25-year-old woman without carney’s complex: case report and literature review
Authors: Meng Tian , Yin Haoqiang , Chen Ling , Wu Jingjing , Cheng Yiqin , Wang Song , Zhao Qiufeng 
Published: November 2022

AbstractBackground:Superficial angiomyxoma (SAM) is a rare, benign tumor characterized by scattered stellate or spindle cells and thin-walled blood vessels embedded in abundant myxoid stroma. It was first reported as a cutaneous myxoma associated with Carney complex in 1985, and lesions are commonly located in the eyelids, external ear canal, and nipples and often appear in multiples. In cases with no evidence of Carney complex, the incidence of breast SAM is extremely rare.Case presentation:We reported a case of a 25-year-old Chinese woman presented with a left breast lump in the subareolar region for three years and gradually increased in size. No evidence of Carney complex was noted. Breast ultrasonography (US) and magnetic resonance imaging (MRI) were undertaken with US BI-RADS 4A and MR BI-RADS 4, respectively. The patient denied biopsy and underwent a lumpectomy and was diagnosed with SAM. There was no tumor recurrence after 18 months of follow-up.Conclusion:This case report suggests that the preoperative US and MRI characteristics of breast SAM are specific and in accordance well with the histological appearances. Recognition of these imaging features may be helpful for the diagnosis of SAM. And complete excision and long-time regular follow-up after surgery are recommended.
Composition of Pseudo-Differential Operators involving the Weinstein Transform
Authors: Upadhyay S. K. , Sartaj Mohd 
Published: November 2022

Abstract

Boundedness results of the composition of two pseudo-differential operators involving the Weinstein transformin Weinstein Sobolev space H0,1α are investigatedby utilizing the theory of Weinstein transform. Some special cases are discussed regarding the composition of two pseudo-differential operators and the estimation of the solution of the heat equation is done by taking the Weinstein transform theory.
MSC Classification: 46F12, 35S05, 47G30, 46E35, 44A35
Comparative study between the efficacy and safety of topical sildenafil citrate solution and topical minoxidil 5%in the treatment of female pattern hair loss .
Authors: Mostafa Heba Abdo , Mohammed Hassan Abou Khodair , Fouda Ibrahim 
Published: November 2022

Abstract
Background: Female pattern hair loss (FPHL) is a nonscarring progressive thinning of hair with gradual decrease in it's number , especially in the frontal, central, and parietal scalp. the loss of terminal hairs in affected areas is usually incomplete and the frontal hairline is often spared. It is caused by follicular miniaturization, a process that gradually reduces the proportion of terminal to vellus hair .
Aim of the work: to evaluate the efficacy and safety of topical sildenafil citrate 1 % solution in comparison with topical minoxidil 5% foam in the treatment of female pattern hair loss .
Patients and methods: This exploratory pilot study included 30 female patients suffering from female pattern hair loss. Included patients were divided into 2 groups ; group1: received 1% topical sildenafil citrate solution and group2: received 5% topical minoxidil foam. Assessment of treatment response was done using trichoscopy.
Results: In group 1(treated with topical sildenafil 1%):There was a statistically significant increase in the vellus hair count in the frontal region, vertex and temporal side after treatment as compared to before treatment. Also, there was statistically significant increase in the terminal hair count in the frontal region and vertex region after treatment as compared to before treatment. There was no statistically significant difference in the hair thickness in all the regions after treatment. , Group 2(treated with topical minoxidil 5% ) there was a statistically significant increase in the Terminal hair count and hair thickness in the frontal region, vertex and temporal side after treatment as compared to before treatment. Also, there was statistically significant decrease in the vellus hair count, but it was detected only in the frontal region.
Conclusion: topical sildinafil 1% treatment proves to be a good alternative in the treatment of FPHL, although topical minoxidil 5% is still the first choice in FPHL treatment.
Transcription analysis of the THBS2 gene through regulation by potential non-coding diagnostic biomarkers and oncogenes of gastric cancer in the ECM receptor interaction signaling pathway: integrated systems biology and experimental investigation
Authors: Barani Ali , Beikverdi Kamyar , Mashhadi Benyamin , Parsapour Naeimeh , Rezaei Mohammad , Azadeh Mansoureh 
Published: November 2022

Abstract
Background
Gastric cancer (GC) is the second most frequent cause of cancer-related death worldwide and the fourth most common malignancy. Despite significant improvements in patient survival over the past few decades, the prognosis for patients with GC remains dismal because of the high recurrence rate. In this comprehensive systems biology and experimental investigation, we aimed to find new novel diagnostic biomarkers of GC through a regulatory RNA interaction network.
Methods
Gene expression, co-expression, and survival analyses were performed using microarray and RNAseq datasets (analyzed by R Studio, GEPIA2, and ENCORI). RNA interaction analysis was performed using miRWalk and ENCORI online databases. Gene set enrichment analysis (GSEA) was performed to find related signaling pathways of up and down-regulated genes in the microarray dataset. Gene ontology and pathway enrichment analysis were performed by the enrichr database. Protein interaction analysis was performed by STRING online database. Validation of expression and co-expression analyses was performed using a qRT-PCR experiment.
Results
Based on bioinformatics analyses, THBS2 (FC: 7.14, FDR < 0.0001) has a significantly high expression in GC samples. lncRNAs BAIAP2-AS1, TSIX, and LINC01215 have RNA interaction with THBS2. BAIAP2-AS1 (FC: 1.44, FDR: 0.018), TSIX (FC: 1.34, FDR: 0.038), and LINC01215 (FC: 1.19, FDR: 0.046) have significant up-regulation in GC samples. THBS2 has a significant role in the regulation of the ECM-receptor signaling pathway. miR-4677-5p has a significant RNA interaction with THBS2. The expression level of THBS2, BAIAP2-AS1, TSIX, and LINC01215 has a non-significant negative correlation with the survival rate of GC patients (HR: 0.28, logrank p: 0.28). qRT-PCR experiment validates mentioned bioinformatics expression analyses. BAIAP2-AS1 (AUC: 0.7136, p-value: 0.0096), TSIX (AUC: 0.7456, p-value: 0.0029), and LINC01215 (AUC: 0.7872, p-value: 0.0005) could be acceptable diagnostic biomarkers of GC.
Conclusion
BAIAP2-AS1, lncRNA LINC01215, lncRNA TSIX and miR-4677-5p might modulate the ECM-receptor signaling pathway via regulation of THBS2 expression level, as the high-expressed non-coding RNAs in GC. Furthermore, mentioned lncRNAs could be considered potential diagnostic biomarkers of GC.
Oxygen Binding to α-Subunits in High-Salt Crystals of t-State Hemoglobin
Authors: Frontice Clara , Gilliland Gary L. , Vasquez Gregory B. , Ji Xinhua , Pechik Igor 
Published: November 2022

Abstract:
The crystal structures of a partially-oxygenated, human, T-state hemoglobin variant, βC112G, and a deoxy structure of a related hemoglobin construct, β (C93A+C 112G), have been determined at 2.0 A and 1.8 A resolution, respectively. Oxygen molecules fully occupy the, α -heme and partially occupy the a.,-heme binding sites of the βC112G mutant hemoglobin. Comparisons of these structures with deoxy-, oxy-, and carboxyhemoglobin provide insight into hemoglobin's allosteric transition.
Improved Crystals of Bovine Neurophysin II
Complexed with Vasopressin
Authors: Hu Bing , Rose John P. , Newton M. Gary , Breslow Esther , Zheng Changsheng , Wang Bi-Cheng 
Published: November 2022

Abstract:
A modified bovine neurophysin II in which the first six residues have been removed by digestion has been crystallized with the hormone vasopressin. The crystals belong to space group P6,22 (or P6322) with unit cell
constants of a = b = 50,9A, c = 105.8 A. Crystals of the vasopressin complex have one subunit of the complex
per asymmetric unit, which corresponds to a solvent content of approximately 40%. The crystals diffract to beyond 2.3A resolution, which is substantially better than the 4 A diffraction reported for the full-length neurophysin-vasopressin complex reported previously.
Development of Silver Nanoparticles Green-formulated by Matricaria Chamomilla as Novel Chemotherapeutic Nanoformulation for the Treatment of Oral Squamous Cell Carcinoma
Authors: Yang Rui , Wang Mingguo , Ma Xiaoxia , Gao Qing 
Published: November 2022

Aim:To develop modern chemotherapeutic nanoformulation from plant extract to treat oral squamous cell carcinoma.Background:The use of biodegradable polymers to deliver drugs via nanoparticles solves a number of issues. AgNPs nanoparticle composites could be a promising material with applications in biological and pharmaceutical sciences. The biomolecules in the extract give the AgNPs additional stability against oxidation and corrosion. As a result, we are interested in reporting the synthesis, characterization, and uses of unique AgNPs decorated with Matricaria chamomilla extract.Objective:We developed a natural chemotherapeutic nanoformulation containing M. chamomilla aqueous extract and silver nanoparticles (AgNPs) for treating oral squamous cell carcinoma.Methods:UV–Visible Spectroscopy (UV-Vis), Fourier Transformed Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), and Field Emission Scanning Electron Microscopy (FESEM) were used to characterize AgNPs. The antioxidant activities of AgNO3, M. chamomilla, and AgNPs were evaluated using the DPPH assay in the presence of Butylated Hydroxytoluene (BHT) as a positive control. The MTT assay was employed on the HSC-4, Ca9-22, and HSC-3 cell lines to assess the cytotoxicity and anti-oral squamous cell carcinoma effects.Results:Silver nanoparticles demonstrated reduced cell viability and anti-oral squamous cell carcinoma capabilities in HSC-4, Ca9-22, and HSC-3 cell lines in a dose-dependent manner, with minimal damage to the normal cell line. The HSC-3 cell line showed the strongest anti-oral squamous cell carcinoma characteristics of AgNPs when tested against the above cell lines.Conclusion:According to the findings, silver nanoparticles containing M. chamomilla aqueous extract may treat different forms of oral squamous cell carcinoma in people.
Computational Fluid Dynamics: Insights and Applications in the
Pharmaceutical Field
Authors: Singh Vanshita , Shah Kamal , Garg Akash , Dewangan Hitesh Kumar 
Published: November 2022

Abstracts:
Computational fluid dynamics (CFD) is a feasible tool to examine and troubleshoot different
types of equipment utilized in the pharmaceutical industry or healthcare. As a large number of fluids are
processed by unit operations, even some increments in performance and efficiency may escalate profits
and reduce costs. CFD methods are primarily used in the automobile and aerospace industries, but in the
current era, this technology is extensively applied in the pharmaceutical and chemical industries and has
become an important tool for process design scaleup and optimization. CFD is a numerical approach utilizing
CFD software to solve equations numerically. This review focuses on the diverse utilization of
CFD in the pharmaceutical field and current applications in the COVID 19 pandemic, a recent health
crisis that is intimidating the world.
Cytotoxic and Apoptotic Impacts of Ceranib-2 on RAW 264.7 Macrophage Cells
Authors: Alanyalı filiz Susuz , Algı Osman 
Published: November 2022

Background:
Many ceramidase inhibitors have been developed and identified as potential treatment agents
for various types of tumors in the last several decades. In recent years, their therapeutic potential against tumors has
gained great attention. Inhibition of ceramidase is r eportedly related to apoptosis and cytotoxicity in macrophages,
which are closely related to tumor development and progression. However, whether and how ceranib-2, a novel
ceramidase inhibitor, can exert its cytotoxic and apoptotic effects on RAW 264.7, a macrophage cell line established
from a tumor in a male mouse induced with the Abelson murine leukemia virus, remains unknown.

Objective:
In this study, we aimed to investigate whether and how ceranib-2 can exert cytotoxic, antiproliferative, and
apoptotic effects on the RAW264.7 macrophages.

Methods:
We performed the MTT assay, Annexin V staining assay, and confocal microscopy to detect the cytotoxicity,
apoptosis, and morphological changes, respectively, in the RAW264.7 cells.

Results:
The viability of RAW264.7 cells treated with ceranib-2 was decreased as the doses of ceranib-2 increased at
24 h and 48 h due to apoptosis resulting from ceranib-2-reduced integrity of the mitochondrial membrane. Moreover,
morphological changes were observed in these ceranib-2 exposed cells, further indicating the role of ceranib-2 in inducing
apoptosis in these cells.

Conclusion:
Ceranib-2 is cytotoxic to RAW 264.7 macrophages and can induce apoptosis in these cells.
Development and Evaluation of Luliconazole Nail Lacquer Containing
Potential Permeation Enhancers for an Enhanced Transungual Drug
Delivery
Authors: Chauhan Preeti , Pahwa Rimpy , Kumari Pooja , Kumar Tarun , Ahuja Munish 
Published: November 2022

Background:
Topical therapy for nail infection has a serious drawback of drug permea-tion via keratinized human nail plate. Onychomycosis, or tinea unguium, is a human nail fungal infection affecting nearly 19% of the world’s population.

Aim:
Purposely, we aimed to develop and evaluate nail lacquer formulations incorporated with lu-liconazole utilizing different permeation enhancers for targeted transungual drug delivery. Nail clippings were treated with luliconazole solution (5% w/v) with or without permeation enhancers and screened by determining the hydration enhancement factor and retention of the drug in the nail clippings. Different batches of nail lacquer formulations were prepared to employ Eudragit, poly-ethylene glycol 400, Tween 80, and permeation enhancer with the highest hydration enhancement factor value.

Methods:
Successively, the formulations were evaluated for studies like compatibility, application, gloss, blush, smoothness of flow, adhesion, non-volatile content, etc. Based on the results of physi-cal characterization and in vitro release study, formulations based on Eudragit RLPO and RSPO containing N-acetylcysteine and urea and the Eudragit RL100 containing urea as penetration en-hancer were found to be potentially useful. Furthermore, a comparative ex vivo evaluation of the formulations for permeation across the nail clippings revealed that the luliconazole-loaded Eudragit RLPO formulations containing N-acetylcysteine and urea provided the highest flux (5.12 μg/cm2/min) and shortest lag time (17.4 min).

Results:
Morphological analysis showed an increase in the number of pores on the nail surface, leading to the enhancement of drug diffusion across the nail matrix and nail bed.

Conclusion:
Furthermore, the luliconazole nail lacquer formulation exhibited higher antifungal ac-tivity, viscosity, and stability properties. Hence, the results suggest that the developed luliconazole nail lacquer formulation is an efficient topical transungual drug delivery system.
Recent Progress on the Application of the Polyaniline-Pd Catalysts for C-C
Cross-coupling Bond Forming Reactions: Trend and Future Analysis
Authors: Roy Moumita 
Published: November 2022

Abstract:
In this review recent progress on the application of the polyaniline supported palladium catalysts in different organic transformations focusing on different C-C bond forming reactions such as Suzuki coupling, Heck reactions, oxidative Heck coupling, Ullmann coupling, Sonogashira and related chemistry. Effect of catalyst preparation, characteristic of the support and supported palladium species on the outcome of the catalyst efficiency are also highlighted. Finally, the emerging trend is summarized for the future of this unique modular catalytic system.
Review on the Importance of Chitosan in Different Pharmaceutical
Applications
Authors: Alkadi Hourieh , Allaf Abdul Wahab 
Published: November 2022

Abstract:
Chitosan is an amino-polysaccharide polymer that has a unique structure, multi properties,
highly sophisticated functionality and a wide range of applications in biomedical and pharmaceutical
research as well as other industrial applications in connection with both pharmaceutical and
medical fields. Additionally, it appears that this unique material can be emphasized as a good candidate
for drugs variety carrier, drug release applications, and ocular and antimicrobial applications
including treatment of diabetes. This review highlights the importance and pharmaceutical applications
of chitosan in different fields of research and applications.
Home Care in the Daily Lives of Older People: Protocol for an Ethnographic Two-Year Longitudinal Study
Authors: Harnett Tove , Jönson Håkan , Fäldtman Alexander 
Published: November 2022

Background
Research on eldercare has been dominated by a provider-oriented perspective, concerned with the conditions and views of care providers. There are striking differences compared with the field of disability studies, where help is framed as part of a larger project of having a daily life and being included in society. Pilot interviews indicate that older people develop active strategies to make care work. These include practical preparations, emotional activities such as showing an interest in staff members’ lives, or rhetorical skills in asking for help.

Objective
The aim of this project is to develop empirical and theoretical knowledge of eldercare as a relational practice, accomplished by older people in their daily lives. This perspective will also offer an alternative to ongoing attempts to reduce the user perspective to an issue about older people acting as customers in a market.

Methods
The project will map, investigate, and follow up on care use from the perspective of care users. The project has an ethnographic 2-year longitudinal approach. Data consist of interviews and participant observations with 35 persons (home care users and cohabitating partners) and a diary study with additional 10 care users. Inclusion criteria are people 65 years or older with home care provided by needs assessors. It is preferred that they have had home care between 6 months and 2 years in order to follow a progression in roles, identities, and strategies within home care use.

Results
Between May and October 2022, 25 interviews with home care users were conducted. Data collection with follow-up interviews and observations, analysis, and reporting of findings will be completed by December 2024.

Conclusions
By studying care use in the context of older people’s lives the project will add important knowledge about the strategies and adjustments older people apply to make care arrangements work. A user-oriented perspective will further the understanding of how power relations play out in home care over time in relation to the formal rights, categorical belongings, and established norm systems that place the user in superior or subordinate positions.

International Registered Report Identifier (IRRID)
PRR1-10.2196/42160
Medication changes implemented during medication reviews and factors related to overprescribing: post-hoc analyses of a randomized clinical trial in geriatric outpatients with polypharmacy
Authors: Kornholt Jonatan , Feizi Shafika , Hansen Alexandra , Laursen Jannie , Johansson Karl , Reuther Lene , Petersen Tonny , Pressel Eckart , Christensen Mikkel 
Published: November 2022

Aims: To describe the medication changes implemented during
physician-led medication reviews that resulted in improved
health-related quality of life; and to explore factors that could
identify patients with overprescription.
Methods: Post-hoc analyses of data from a pragmatic,
non-blinded, randomized clinical trial investigating a medication review
intervention (NCT03911934) in 408 geriatric outpatients taking
≥9 medicines.
Results: The most frequent medicine change in the medication
review group (n=196) was discontinuation (26% of the medicines) due to
lack of indication (72% of the discontinuations). After 13 months, 82%
of the discontinued medicines were persistently discontinued. The
medicines most often discontinued in the medication review group
compared with usual care included: metoclopramide (11/5=73%
discontinued vs 1/12=8% in usual care), acetylsalicylic acid
(20/48=42% vs 2/47=4%), simvastatin (18/48=38% vs 2/58=3%),
zopiclone (23/59=39% vs 4/54=7%), quinine (9/14=64% vs 6/16=38%),
citalopram (4/18=22% vs 0/20=0%), and tramadol (18/37=49% vs
8/30=27%). Factors associated with the number of overprescribed
medicines included: number of prescribed medicines (8% increase per
medicine), Drug Burden Index (15% increase per 1 increase), and patient
motivation for medicine changes (26% less if not motivated).
Prescriptions of metoclopramide, iron preparations, antidepressants
other than SSRIs, NSAIDs, or drugs for urinary incontinence were
associated with a higher number of overprescribed medicines.
Conclusion: Medication reviews can be used to persistently
discontinue overprescribed medicines in older polypharmacy patients.
Motivation for having their medicine changed, treatment with a higher
number of medicines, and a higher burden of sedative and anticholinergic
drugs characterized patients most likely to benefit from physician-led
medication reviews.
Efficacy and Safety of Dapagliflozin by Baseline Insulin Regimen and Dose: Post Hoc Analyses From DECLARE-TIMI 58
Authors: Pollack Rena , Raz Itamar , Wiviott Stephen D. , Goodrich Erica L. , Murphy Sabina A. , Yanuv Ilan , Rozenberg Aliza , Mosenzon Ofri , Langkilde Anna Maria , Gause-Nilsson Ingrid A.M. , Bhatt Deepak L. , Leiter Lawrence A. , McGuire Darren K. , Wilding John P.H. , Sabatine Marc S. , Cahn Avivit 
Published: November 2022

OBJECTIVE
The cardiorenal benefits of adding sodium–glucose cotransporter 2 (SGLT2) inhibitor therapy for patients on insulin, particularly those on intensive regimens that include short-acting (SA) insulin, have not been explored.

RESEARCH DESIGN AND METHODS
In Dapagliflozin Effect on Cardiovascular Events trial (DECLARE-TIMI 58), 17,160 patients with type 2 diabetes were randomized to dapagliflozin or placebo for a median follow-up of 4.2 years. Cardiovascular (CV), renal, metabolic, and safety outcomes with dapagliflozin versus placebo by insulin dose and regimen were studied with Cox regression models.

RESULTS
The study included 7,013 insulin users at baseline, with 4,650 (66.3%) patients on regimens including SA insulin. Insulin doses varied, with 2,443 (34.8%) patients receiving &lt;0.5 IU/kg, 2,795 (39.9%) 0.5 to ≤1 IU/kg, and 1,339 (19.1%) &gt;1 IU/kg. Dapagliflozin reduced CV death/hospitalization for heart failure among overall insulin users (hazard ratio [HR] 0.82 [95% CI 0.69–0.97]) and consistently in patients on insulin regimens with or without SA insulin (0.83 [0.67–1.03] and 0.78 [0.57–1.07], respectively, Pinteraction = 0.75). No heterogeneity was observed by insulin dose (Pinteraction = 0.43). The HR for major adverse CV events with dapagliflozin among insulin users (0.84 [0.74–0.97]) was similar irrespective of regimen or dose (Pinteraction = 0.75 and 0.07). Dapagliflozin reduced the rate of adverse renal outcomes overall and consistently across subgroups of insulin users. Decreases in HbA1c, weight, and systolic blood pressure with dapagliflozin were seen regardless of insulin dose or regimen. The known safety profile of dapagliflozin was unchanged in patients on intensive insulin regimens.

CONCLUSIONS
The benefits and safety of dapagliflozin were maintained in high-risk patients receiving high-dose or intensive insulin regimens including SA insulin.