bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive therapeutic exercise in early proprioception recovery after knee osteoarthritis surgery
Authors: Ma Yubao , Fan Zhijiao , Gao Weiguang , Yu Zihan , Ren Muchen , Ma Quansheng , Song Dejun , Zhang Lihua , Mi Lixin 
Published: August 2022

ObjectiveThis research aims to explore the therapeutic effect of cognitive therapeutic exercise (CTE) in proprioception recovery after knee osteoarthritis (KOA) surgery.MethodsIn total, thirty-seven patients recovering from KOA surgery (including 27 patients who had undergone high-tibial osteotomy (HTO) procedure and 10 patients who had received total knee arthroplasty (TKA) treatment were randomly assigned to two groups: 18 patients in the CTE group and 19 patients for the control group (non-CTE). Patients in the CTE group received proprioceptive training as cognitive therapy to facilitate proprioception recovery for up to 4 weeks: 5 days a week and two 10-min sessions a day. Except for cognitive therapeutic exercise, the NCTE group and CTE group had the same treatment protocols. All the interventions began with permission from the surgeon-in-charge. In this research, we applied the joint repositioning training or joint-matching tasks, which is part of the proprioceptive training as a measurement for a proprioceptive training result where patients moved their knee joint from 0° (completely straight knee joint) to produce a presented joint angle, such as 30, 60, and 90° of flexion. Joint-matching task results were recorded before the treatment, at 2 and 4 weeks, postoperatively. The absolute difference between the results of these exercises and the knee flexion angle targets will be measured at each test—pre-rehabilitation (Pre-Reha), 2 weeks post-rehabilitation (2 weeks post-Reha), and 4 weeks post-rehabilitation (4 weeks post-Reha).ResultsThe absolute difference in the CTE group was significantly smaller than that of the control group after 4 weeks of treatment (P &lt; 0.05). After 2 weeks of cognitive therapeutic exercise, the absolute difference between patients' exercises of joint repositioning and the target angle of 30° in the CTE group was smaller than that of the NCTE group (P &lt; 0.01). After 4 weeks of therapy, the joint position sense (JPS) among patients who received cognitive therapeutic exercise when performing joint repositioning at angles of 30 and 60° were better improved than those without receiving proprioceptive training with the absolute difference smaller than those of the control group (P &lt; 0.05).ConclusionThe joint reposition training provided for the CTE group is a painless proprioceptive training practice. This method is simple and effective, making it easy for patients to understand the purpose of training and improve patient engagement. The research showed that after 4 weeks of rehabilitation and physical training, the proprioception sense of both the NCTE and CTE groups improved significantly, and the efficacy of proprioceptive training in the CTE group was better than that of the NCTE group, which provided a new approach to the early proprioception recovery of a patient with KOA after surgery.
A DNA-Damage Inducible Gene Promotes the Formation of Antibiotic Persisters in Response to the Quorum Sensing Signaling Peptide in Streptococcus mutans
Authors: Dufour Delphine , Zhao Haowei , Gong Siew-Ging , Lévesque Céline M. 
Published: August 2022

Bacteria use quorum sensing (QS) to communicate with each other via secreted small autoinducers produced by individuals. QS allows bacteria to display a unified response that benefits the species during adaptation to environment, colonization, and defense against competitors. In oral streptococci, the CSP-ComDE QS is an inducible DNA damage repair system that is pivotal for bacterial survival. In the oral pathogen Streptococcus mutans, the QS system positively influences the formation of antibiotic persisters, cells that can survive antibiotic attack by entering a non-proliferative state. We recently identified a novel gene, pep299, that is activated in the persister cell fraction induced by QS. In this study, we focused our investigation on the role of pep299, a gene encoding a bacteriocin-like peptide, in the formation of antibiotic persisters. Mutant Δ299, unable to produce Pep299, showed a dramatic reduction in the number of stress-induced persisters. Using a co-culture assay, we showed that cells overproducing pep299 induced the formation of persisters in the mutant, suggesting that Pep299 was actively secreted and detected by neighboring cells. Cells exposed to DNA damage conditions activated the gene expression of pep299. Interestingly, our results suggested that the pep299 gene was also involved in the regulation of a QS-inducible toxin–antitoxin system. Our study suggests that the pep299 gene is at the core of the triggered persistence phenotype in S. mutans, allowing cells to transition into a state of reduced metabolic activity and antibiotic tolerance.
Effect of Supplementation with the Combination of Se-Enriched Lentinula edodes Mycelium, Exogenous Enzymes, Acidifiers, Sodium Butyrate and Silicon Dioxide Nanoparticle Feed Additives on Selected Parameters in Calves
Authors: Szacawa Ewelina , Dudek Katarzyna , Wasiak Magdalena , Bednarek Dariusz , Bederska-Łojewska Dorota , Muszyńska Bożena , Pieszka Marek 
Published: August 2022

During the initial months of calves’ lives, the young animals are exposed to bacterial and viral infections, and during this period, crucial physiological changes take place in their organisms. Offering calves feed additives that will have a beneficial influence on their organisms and improve their growth while reducing the morbidity rate is the optimal task of feeding. This is the first study to investigate the effect of experimental supplementation for calves with the combination of two feed additives—one containing Lentinula edodes enriched with selenium (Se), and the second containing pancreatic-like enzymes, fat-coated organic acids, sodium butyrate, and silicon dioxide nanoparticles—on the serum Se concentration, selected immune parameters, and the average daily gains in the calves. During the study, the serum Se concentration was examined by means of inductively coupled plasma mass spectrometry, and the immunoglobulin and cytokine concentrations with ELISA assays. The white blood cell (WBC) count with leukocyte differentiation was examined with the use of a hematological analyzer, and the percentages of subpopulations of T lymphocytes and monocytes, phagocytic activity, and oxidative burst of monocytes and granulocytes with the use of a flow cytometer. The average daily gains of the calves were also evaluated. In summary, the supplementation of the experimental calves with the combination of two feed additives resulted in significantly higher serum Se concentrations, and the immune systems of the calves were not suppressed while the examined feed additives were being delivered. Although not statistically significant, some positive effects on the calves were seen: a tendency towards the improvement of some of the immune parameters evaluated, and a tendency for higher average daily gains in the calves.
Prominent Mitochondrial Injury as an Early Event in Heme Protein-Induced Acute Kidney Injury
Authors: Singh Raman Deep , Croatt Anthony J. , Ackerman Allan W. , Grande Joseph P. , Trushina Eugenia , Salisbury Jeffrey L. , Christensen Trace A. , Adams Christopher M. , Tchkonia Tamara , Kirkland James L. , Nath Karl A. 
Published: August 2022

Key Points

In heme protein–induced AKI, mitochondrial functional integrity, as reflected by ATP and NAD+ content and NAD+/NADH ratio, is impaired.Mitochondrial quality control is compromised as reflected by impaired biogenesis, exaggerated fission, and marked ultrastructural damage.Modern concepts regarding mitochondria and AKI apply to heme protein–induced AKI, with the possibility of novel therapeutic strategies.

Background
Mitochondrial injury occurs in and underlies acute kidney injury (AKI) caused by ischemia-reperfusion and other forms of renal injury. However, to date, a comprehensive analysis of this issue has not been undertaken in heme protein–induced AKI (HP-AKI). We examined key aspects of mitochondrial function, expression of proteins relevant to mitochondrial quality control, and mitochondrial ultrastructure in HP-AKI, along with responses to heme in renal proximal tubule epithelial cells.

Methods
The long-established murine glycerol model of HP-AKI was examined at 8 and 24 hours after HP-AKI. Indices of mitochondrial function (ATP and NAD+), expression of proteins relevant to mitochondrial dynamics, mitochondrial ultrastructure, and relevant gene/protein expression in heme-exposed renal proximal tubule epithelial cells in vitro were examined.

Results
ATP and NAD+ content and the NAD+/NADH ratio were all reduced in HP-AKI. Expression of relevant proteins indicate that mitochondrial biogenesis (PGC-1α, NRF1, and TFAM) and fusion (MFN2) were impaired, as was expression of key proteins involved in the integrity of outer and inner mitochondrial membranes (VDAC, Tom20, and Tim23). Conversely, marked upregulation of proteins involved in mitochondrial fission (DRP1) occurred. Ultrastructural studies, including novel 3D imaging, indicate profound changes in mitochondrial structure, including mitochondrial fragmentation, mitochondrial swelling, and misshapen mitochondrial cristae; mitophagy was also observed. Exposure of renal proximal tubule epithelial cells to heme in vitro recapitulated suppression of PGC-1α (mitochondrial biogenesis) and upregulation of p-DRP1 (mitochondrial fission).

Conclusions
Modern concepts pertaining to AKI apply to HP-AKI. This study validates the investigation of novel, clinically relevant therapies such as NAD+-boosting agents and mitoprotective agents in HP-AKI.
تقييم تجربة جامعة السلطان قابوس للتعلم عن بُعد باستخدام منصة موودل (Moodle) في ظل جائحة فيروس كورونا المستجد" كوفيد-19" من وجهة نظر أعضاء الهيئة التدريسية
Authors: Shahat Mohamed , Al-amri Mohammed 
Published: August 2022

الأهداف: هدفت هذه الدراسة إلى تقييم تجربة جامعة السلطان قابوس في التعلم عن بُعد باستخدام منصة موودل (Moodle) في ظل جائحة فيروس كورونا المستجد" كوفيد-19" من وجهة نظر أعضاء الهيئة التدريسية.
المنهجية: استُخدم في الدراسة المنهج الوصفي التحليلي، بالاعتماد على استبانة لتقييم التجربة.
النتائج: أظهرت النتائج أن تجربة التعلم عن بعد كانت فاعلة بدرجة متوسطة من وجهة نظر أعضاء هيئة التدريس، وكشفت كذلك عن وجود فروق دالة إحصائيًا بين آراء أعضاء هيئة التدريس تعزى إلى متغير الجنس، في حين لم يوجد أثر دال إحصائيًا لمتغير الخبرة التدريسية.
التوصيات: قدمت الدراسة بعض التوصيات؛ تضمنت الحاجة إلى عقد برامج وورش تدريبية لزيادة الوعي بالثقافة التكنولوجية، وتوظيف نظم إدارة التعليم الإلكتروني عن بُعد، وتصميم المقررات الإلكترونية.
Statistical investigation of dislocation induced leakage current paths in AlGaN/GaN HEMT structures on Si and the impact of growth conditions
Authors: Besendörfer Sven , Meissner Elke , Friedrich Jochen 
Published: August 2022

Abstract
Threading dislocations in the AlGaN-barrier of four pairwise differently grown AlGaN/GaN high electron mobility transistor structures on Si were investigated with respect to their structural and electrical properties in direct comparison simultaneously ensuring statistical significance of the results. Portions of pure screw and mixed type dislocations were observed to serve as leakage current paths and to be clearly dependent on growth conditions like the AlN nucleation layer growth temperature. The role of impurity segregation at dislocation cores due to growth-dependent locally characteristic strain fields as for example induced by specific dislocation reactions at the AlGaN/GaN interface is discussed as the origin.
INSTRUMENTO DE PLANIFICACIÓN Y EVALUACIÓN DIDÁCTICA DE CUESTIONES SOCIOCIENTÍFICOS (IPADQSC) COMO MATERIAL DIDÁCTICO DE APOYO AL PROFESOR
Authors: Da Silva Fonseca Aleson , Ivaneide Alves Soares da Costa  
Published: August 2022

Objetivou-se validar o Instrumento de Planejamento e Avaliação Didática de Questões Sociocientíficas (IPADQSC), como material instrucional de apoio ao professor para auxiliar no planejamento e avaliação das sequências de ensino, com foco na ampliação do letramento científico dos estudantes. A validação ocorreu em três fases: (i) elaboração do instrumento e de critérios de análise; (ii) análise e apreciação aos pares; (iii) aplicação do material. A geração e definição de itens para composição do instrumento e o estabelecimento de critérios de avaliação foi baseada no referencial teórico sobre ensino investigativo, questões sociocientíficas, divulgação e letramento científico, e orientações didático pedagógica. A análise foi realizada por 30 avaliadores da área, considerando três categorias: estrato baixo, composto por estudantes de pós-graduação em ensino de ciências; estrato médio, incluindo professores da educação básica; estrato alto, representado por professores universitários. Todos avaliaram o mesmo questionário composto por 29 critérios sobre aspectos teóricos, metodológicos e didáticos referente ao instrumento. A apreciação dos pares revelou que sete dos 29 critérios estavam abaixo do percentual de anuência, cuja indicações foram atendidas para conferir melhor clareza. O instrumento foi aplicado para 107 professores de Ciências e Biologia em formação inicial e continuada durante um curso de formação na forma de ensino remoto devido a pandemia. Observou-se que os professores participantes demonstraram bom entendimento e facilidade para uso do instrumento para elaboração de 21 propostas de sequência de ensino, como atividade avaliativa do curso, sugerindo que o IPADQSC atendeu aos critérios de estrutura e organização, relevância didática, questões teóricas e metodológicas satisfatoriamente. Verificou-se que o instrumento se torna válido e pode ser amplamente divulgado para utilização na prática pedagógica, na sua forma original ou com adaptações, atendendo a diferentes realidades.
LA INTRODUCCIÓN DE RESULTADOS INVESTIGATIVOS Y LA GESTIÓN DIDÁCTICA DE LOS DOCENTES EN LA PRÁCTICA EDUCATIVA
Authors: Nápoles Delia Sarduy , Cárdenas Estrella Sobrado , Morales Carlos Basulto , Recio Nancy Montes de Oca 
Published: August 2022

La investigación surge por necesidad de socializar y sistematizar resultados científicos del Grupo de investigación en Matemática Educativa de la Universidad de Camagüey (GIMEUC) mediante el proceso de introducción de resultados en la práctica educativa. Su objetivo, introducir y generalizar resultados de investigaciones y valorar su impacto, para perfeccionar la enseñanza-aprendizaje de la Matemática preuniversitaria desde la superación de los docentes. La metodología abarcó métodos y técnicas de la investigación pedagógica, entre ellos, la observación, el análisis documental, el cuestionario. Se desarrolló en tres fases. La primera precisó el cuerpo categorial, fundamentos teóricos y dimensiones e indicadores para seleccionar resultados a introducir, docentes introductores y centros docentes. En la segunda se elaboraron estrategia metodológica para dirigir dicho proceso, orientaciones metodológicas para tratamiento del contenido matemático, acompañamiento a docentes introductores, trabajo con el claustrillo de grado y familiares de estudiantes. Se elaboraron instrumentos para valorar impacto. En la tercera fase se prepararon investigadores y directivos, entrenaron profesores introductores y aplicaron las orientaciones metodológicas. Entre los principales impactos se constató mejora del desempeño docente, del proceso de enseñanza-aprendizaje de la Matemática, fortalecimiento de relaciones Universidad y Dirección Provincial de Educación, consolidación de relaciones entre profesores universitarios, alumnos ayudantes, directivos y docentes del MINED.
Stars That Approach within One Parsec of the Sun: New and More Accurate Encounters Identified in Gaia Data Release 3
Authors: Bailer-Jones C. A. L. 
Published: August 2022

Abstract
Close encounters of stars to the Sun could affect life on Earth through gravitational perturbations of comets in the Oort cloud or exposure to ionizing radiation. By integrating orbits through the Galactic potential, I identify which of 33 million stars in Gaia DR3 with complete phase space information come close to the Sun. 61 stars formally approach within 1 pc, although there is high confidence in only 42 (two thirds) of these, the rest being spurious measurements or (in) binary systems. Most of the stars will encounter within the past or future 6 Myr; earlier/later encounters are less common due to the magnitude limit of the Gaia radial velocities (RVs). Several close encountering stars are identified for the first time, and the encounter times, distances, and velocities of previously known close encounters are determined more precisely on account of the significantly improved precision of Gaia DR3 over earlier releases. The K7 dwarf Gl 710 remains the closest known encounter, with an estimated (median) encounter distance of 0.0636 pc (90% confidence interval 0.0595–0.0678 pc) to take place in 1.3 Myr. The new second closest encounter took place 2.8 Myr ago: this was the G3 dwarf HD 7977, now 76 pc away, which approached within less than 0.05 pc of the Sun with a probability of one third. The apparent close encounter of the white dwarf UPM J0812-3529 is probably spurious due to an incorrect RV in Gaia DR3.
Can the Distance‒Redshift Relation be Determined from Correlations between Luminosities?
Authors: Petrosian V. , Singal J. , Mutchnick S. 
Published: August 2022

Abstract
We explore whether an independent determination of the distance‒redshift relation, and hence cosmological model parameters, can be obtained from the apparent correlations between two different wave-band luminosities or fluxes, as has been claimed in recent works using the X-ray and ultraviolet luminosities and fluxes of quasars. We show that such an independent determination is possible only if the correlation between luminosities is obtained independently of the cosmological model and measured fluxes and redshifts, for example, based on sound theoretical models or unrelated observations. In particular, we show that if the correlation is determined empirically for two luminosities obtained from fluxes and redshifts, then the method suffers from circularity. In the case where the observed correlation between fluxes in very narrow redshift bins is used as a proxy for the luminosity correlation, we show that one is dealing with a pure tautology with no information on distances and cosmological model. We argue that the problem arises because of the incomplete treatment of the correlation, and we use numerical methods with a joint X-ray and ultraviolet quasar data set to demonstrate this shortcoming.
The Lumbopelvic-Hip Complex Contribution During Lower Extremity Screening Tests in Elite Figure Skaters
Authors: Webb Brittney , Kenning Jessica Harris , Guzman Aracelis , Slater Lindsay , Mangum L. Colby 
Published: August 2022

Context
Figure skating requires power and stability for takeoff and landing from multirotational jumps and various on-ice skills. Repetitive forces may cause overuse injuries distally, making lumbopelvic-hip endurance, strength, and neuromuscular control imperative.

Objective
To compare lumbopelvic-hip endurance and neuromuscular control in elite figure skaters between sexes and landing and nonlanding limbs using common screening tests.

Design
Cross-sectional study.

Setting
US Olympic and Paralympic Training Center.

Patients or Other Participants
Forty elite figure skaters (20 women, 20 men; age = 23.2 ± 4.3 years) performed the Y-balance test, single-legged squat (SLS), single-legged squat jump (SLSJ), and unilateral hip-bridge endurance test (40 right [R] landing limbs, length = 169.1 ± 12.2 cm).

Main Outcome Measure(s)
Normalized reach difference (% of leg length) and composite scores [(anterior + posteromedial + posterolateral)/(limb length × 3) × 100] were calculated for the Y-balance test. Skaters held the unilateral hip bridge until failure with a maximum allotted time of 120 seconds. They performed 5 SLSs and 5 SLSJs while barefoot with the contralateral limb held behind them to mimic a landing position. Both tests were scored by the number of times the patella moved medially to the first ray (medial knee displacement [MKD]). Multivariate analyses of variance with post hoc independent t tests were conducted between sexes and groups. Paired t tests were used to analyze limb differences.

Results
Women had a larger composite Y-balance score (R = 10.8% of leg length, P = .002; left = 10.5%, P = .001) and hip-bridge hold time (R = 26.4 seconds, P = .004; left = 28.2 seconds, P = .002) for both limbs compared with men. Men held the hip-bridge longer on their landing limb. Six skaters performed worse on their nonlanding limb during the SLS, and 11 skaters had no MKD with either the SLS or SLSJ.

Conclusions
Women performed better on the Y-balance and unilateral hip bridge tests. Increased MKD for some skaters during the SLS and SLSJ may have indicated hip-abductor weakness. Understanding the proximal lumbopelvic-hip variables during takeoff and landing may elucidate contributing factors to distal overuse injuries.
Utilizing Artificial Intelligence and Finite Element Method to Simulate the Effects of New Tunnels on Existing Tunnel Deformation
Authors: Baghbani Abolfazl , Baghbani Hasan , Shalchiyan Mohamad Mahdi , Kiany Katayoon 
Published: August 2022

Buildings and infrastructure should be constructed while maintaining the safety of the existing infrastructure. Since tunnels are an essential component of urban infrastructure, building new tunnels next to existing ones may have unintended consequences. This study aims to examine the effects of building a new tunnel next to an existing tunnel under different conditions. Two-dimensional models have been developed using the finite element method (FEM) for the existing tunnel, with a diameter of 5 meters, and for the new tunnel, with a diameter that differs from the existing tunnel. Then, the effects of two factors, namely the distance between the two tunnels and the diameter of the new tunnel, were examined on the horizontal, vertical, and total deformation of the soil and the existing tunnel. For the first time, this study attempts to predict the effect of new tunnels on existing tunnels using artificial intelligence (AI) methods. Due to the importance of tunnels and the increasing number of tunnels being constructed in urban areas, this issue will be of great interest. For analyzing the feasibility of using mathematical methods to predict tunnel deformation, the multiple linear regression (MLR) method and an AI technique, namely classification and regression random forests (CRRFs), were used to utilize the generated database. Analyzing FEM results represented that by increasing the diameter of the new tunnel from 3 to 5, horizontal and vertical displacement of the existing tunnel increased by approximately 5 and 10 times, respectively. Further, by reducing the distance between the new tunnel and the existing tunnel from 11 meters to 6 meters, the intensity of horizontal and vertical deformation of the existing tunnel increased by about 2 and 3 times, respectively. Moreover, the results of mathematical models demonstrated that the CRRF method was more accurate than the MLR method, with R of 0.94 and mean absolute error of 2.89 for the testing database, which indicated its proper performance.

Received: 1 July 2022 | Revised: 5 August 2022 | Accepted: 12 August 2022

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
Data available on request from the corresponding author upon reasonable request.