bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authors: Pratama Finsa Adhi , Sumantri Sumantri 
Published: July 2022

Abstrak: Pemikiran Harun Nasution kerap menjadi bahan diskusi panjang di kalangan pemikir dan cendikiawan, salah satunya adalah pernyataan bahwa keterbelakangan umat Islam adalah dampak dari sikap meninggalkan pemikiran rasionalisme, akal melambangkan kekuasaan manusia. Berangkat dari berbagai macam pemikiran dan respon dari para pemikir dan cendikiawan, maka kami tertarik untuk meneliti salah satu domain pemikiran yang dibawa oleh Harun Nasution terkait kekuasaan, kehendak mutlak Tuhan dan kebebasan manusia dalam sebuah analisis pemikiran. Penelitian ini penulis menggunakan metode penelitian kualitatif kepustakaan dan analisis interpretatif, penulis berusaha mengumpulkan data kemudian menyaring dan meneliti serta menukil berbagai data yang kemudian diinterpretasi dala rangkan mendapatkan sebuah kesimpulan yang valid. Metode validasi penulis menggunakan triangulasi metode, waktu dan teori. Harun Nasution memandang bahwa kekuasaan dan kehendak Tuhan dibatasi oleh pemikiran rasional, Tuhan telah memberikan kebebasan kepada manusia sesuai dengan Sunnatullah-Nya. Tuhan memberikan kebebasan kepada manusia untuk menentukan apa yang dikehendakinya. Kebebasan manusia ini dengan sendirinya membatasi kekuasaan dan kehendak Tuhan. Kalau Tuhan tidak membatasi kekuasaan dan kehendak-Nya dalam hal ini, manusia sebenarnya tidak mempunyai kebebasan. Ini bertentangan dengan kenyataan bahwa manusia tiap hari menentukan apa yang dikehendaki dan apa yang diperbuatnya. Tiap saat manusia dihadapkan dengan soal memilih dari beberapa alternatif yang dijumpainya dalam hidup sehari-hari.
Kata Kunci: Kekuasaan Tuhan, Kehendak Mutlak Tuhan, Kebebasan Manusia, Harun Nasution
Authors: Ani Mufti Mahira Mujahida , Anita Anita , Afiati Evi 
Published: July 2022

Sebagai bekal pada masa sekolah, literasi penting diperkenalkan kepada anak pra sekolah. Taman Baca Masyarakat (TBM) merupakan salah satu sarana yang memfasilitasi anak pra sekolah dalam mengenal literasi. Berkaitan dengan hal tersebut, maka penting untuk mengeksplor bagaimana TBM memperkenalkan literasi kepada anak pra sekolah. Untuk itu, penelitian ini membahas tentang peran taman baca masyarakat dalam pengenalan literasi dasar kepada anak-anak usia dini di Desa Cigadung. Penelitian ini menggunakan pendekatan kualitatif dimana teknik pengumpulan data dilakukan melalui wawancara, observasi, dan kajian pustaka. Penelitian ini bertujuan untuk mengetahui bagaimana relawan mengelola Taman Baca Masyarakat Bilik Urang dan mengimplementasikan strategi pengajaran literasi dasar.
Role of miRNA in drug-induced hepatic injury
Authors: Inam Sameh Arif  , Israa Burhan Raoof  , Hayder Hussein Luaibi  , Shams Khaleel Ibraheem  
Published: July 2022

Acute liver disease is characterized by loss of liver function within days or weeks however, in the patient who is not previously diagnosed, its less common compared with chronic liver failure, which developed slowly and irreversible process. It’s caused by

drug-induced liver damage (DILI) therefore identifying liver injury is challenging for clinical treatment and diagnosis. The major causes of liver failure involve toxic metabolites of some medications that consumed Adenosine Tri Phosphate (ATP) compared with normal conditions and increased oxidative stress due to overexpression of MicroRNAs, it is necessary to do complete diagnosis of patients. Biomarker parameters can be utilized to validate liver damage like microRNAs (miRNAs) analysis, it is a more receptive marker because increased earlier than the transaminases enzymes allowing for a more accurate diagnosis. we summarized recent signs of progress disease concerning the role of miRNA as a novel DILI biomarker, the miRNA levels can be measured in plasma, saliva, urine, fetal fluid (amniotic), as well as other materials either in human or animals like mice, rats which significantly elevate during illness, therefore, provide e specific biomarker of hepatoinjury.
Cytotoxicity of Cryptochlorogenic acid against Breast cancer cell line (MCF7) isolated from Moringa oleifera Leaves Cultivated in Iraq
Authors: Banan Kareem Bedewi  , Ghaith Ali Jasim  , Ibrahim Saleh Abbas  , BasmaTalib Al-Sudani  
Published: July 2022

oleifera L., a Moringaceae family is fast-growing tree. M. oleifera's dried leaves are Characterized with high in phenolic compounds. phenolic compounds have anti-cancer, anti-microbial, anti-inflammatory, anti-allergic and antioxidant activities.

Therefore, The current study involved isolation Cryptochlorogenic acid by preparative TLC from M.oleifera leaves grown in Iraq, and study its cytotoxicity effect against a breast cancer cell line (MCF7) using the MTT cell viability assay, and comparing it to a standard anticancer drug (Tamoxifen). The isolated Cryptochlorogenic acid was cytotoxic to the MCF7 cell line, with an IC50 of 20.8M.
Pengaruh Evaluasi Kinerja Guru Terhadap Motivasi Belajar Siswa
Authors: Ermianto Ermianto 
Published: July 2022

Tujuan penelitian ini, yaitu: Untuk mengetahui evaluasi kinerja guru SMPN Satu Atap 5 Dusun Selatan Kabupaten Barito Selatan. Untuk mengetahui motivasi belajar siswa SMPN Satu Atap 5 Dusun Selatan. Untuk mengetahui pengaruh evaluasi kinerja guru terhadap motivasi belajar siswa SMPN Satu Atap 5 Dusun Selatan.
Evaluasi kinerja guru SMPN Satu Atap 5 Dusun Selatan Kabupaten Barito Selatan dilaksanakan dalam kurun waktu satu tahun berjalan oleh kepala sekolah. Motivasi belajar siswa SMPN Satu Atap 5 Dusun Selatan Kabupaten Barito Selatan secara umum telah berjalan dengan baik. Hal ini dapat diketahui dari keaktifan siswa untuk mengikuti proses belajar mengajar di kelas, selain itu juga dari hasil ulangan yang semakin membaik. Berdasarkan penelitian yang telah penulis laksanakan ternyata terdapat korelasi yang signifikan antara evaluasi kinerja guru terhadap motivasi belajar siswa di SMPN Satu Atap 5 Dusun Selatan. Bahwa berdasarkan perhitungan pengaruh evaluasi kinerja guru terhadap motivasi belajar siswa SMPN Satu Atap 5 Dusun Selatan Kabupaten Barito Selatan adalah sebesar 0,703, hal ini berarti bahwa terdapat korelasi yang cukup signifikan dan bernilai positif antara evaluasi kinerja guru terhadap motivasi belajar siswa.
Hubungan Gaya Belajar Dan Motivasi Belajar Dengan Hasil Belajar Ekonomi Peserta Didik Kelas XI IPS II
Authors: Sri Suyati Endang 
Published: July 2022

Penelitian ini bertujuan untuk mengetahui: 1) Hubungan gaya belajar peserta didik dengan hasil belajar ekonomi pada kelas XI IPS II di SMA Negeri 1 Palangka Raya, 2) Hubungan motivasi belajar peserta didik dengan hasil belajar ekonomi pada kelas XI IPS II di SMA Negeri 1 Palangka Raya, 3) Hubungan gaya belajar dan motivasi belajar peserta didik dengan hasil belajar ekonomi kelas XI IPS II di SMA Negeri 1 Palangka Raya.
Metode Penelitian yang digunakan adalah metodelogi kuantitatif. Adapun populasi pada penelitian ini adalah peserta didik kelas XI IPS II di SMA Negeri 1 Palangka Raya yaitu sebanyak 37 orang peserta didik.Variabel yang digunakan dalam penelitian ini ada 3 (tiga) variabel yaitu variabel bebas gaya belajar dan motivasi belajar, sedangkan variabel terikat adalah hasil belajar ekonomi. Dan teknik pengumpulan data menggunakan teknik angket/tes dan teknik analisis menggunakan korelasi product moment dan korelasi ganda.
Hasil penelitian terhadap 37 orang peserta didik kelas XI IPS II di SMA Negeri 1 Palangka Raya yang menjadi populasi penelitian, maka dapat disimpulkan bahwa: 1) Ada hubungan positif yang signifikan gaya belajar peserta didik dengan hasil belajar ekonomi kelas XI IPS II di SMA Negeri 1 Palangka Raya dengan koefisien korelasi Γ_x1y 0,459,termasuk hubungan sedang, 2) Ada hubungan positif yang signifikan antara gaya belajar peserta didik dengan hasil belajar ekonomi kelas XI IPS II di SMA Negeri 1 Palangka Raya dengan koefesien korelasi Γ_x1y= 0,558, termasuk hubungan sedang, 3) Ada hubungan positif yang signifikan antara gaya belajar dan motivasi belajar peserta didik dengan hasil belajar ekonomi kelas XI IPS II di SMA Negeri 1 Palangka Raya dengan koefesien korelasi Γ_x1x2y= 0,586, termasuk hubungan yang sedang.
The e-learning survey analysis in Universitas Sarjanawiyata Tamansiswa: Should it be improved?
Authors: Pusporini Widowati , Septiani Devi , Susanti Susanti 
Published: July 2022

E-learning is not a new issue in education. This research aims to analyze the readiness of early-semester students to implement e-learning at Universitas Sarjanawiyata Tamansiswa. The readiness of students in facing lectures in this pandemic period is considered to be an important issue in the implementation of online lectures. This study is qualitative research using survey methods to describe students' responses to university e-learning in an even semester. This research was conducted by disseminating survey instruments using the RASE model to students using SIPEDAR (university e-learning platform) and academic portal. The research subjects were students in the Educational Research and Evaluation Post-Graduate program and undergraduate science education program in Universitas Sajanawiyata Tamansiswa. The finding of this study stated that Students' responses on e-learning resources had an average of 3.29 (excellent). The students' responses to the activity features in e-learning reached an average of 3.25 (excellent). The student's response to the support features in e-learning with an average of 3.16 (excellent), and The student's response indicator on evaluation in e-learning by 3.21 (excellent).
Pengembangan Aplikasi Media Pembelajaran Biologi Tentang Mata Menggunakan Teknologi Augmented Reality
Authors: Andriyanto Sidhiq , Josi Ahmat 
Published: July 2022

Salah satu inovasi game technology yang akan digunakan dalam membangun media pembelajaran biologi tentang mata sebagai penunjang kegiatan belajar mengajar siswa adalah Augmented Reality(AR), yaitu penggabungan dunia nyata dengan dunia maya, dimana objek virtual overlayed pada dunia nyata. Dari segi teknis, teknologi Augmented Reality merupakan teknologi transformatif, demana sistem intraksi melikupi keseluruhan lingkungan di luar tampilan layar. Dari segi strategis, pemanfaatan media pembelajaran berbasis Augmented Reality sangat berpengaruh dalam peningkatan minat belajra siswa untuk mengetahui dan memahami tentang mata melalui visual 3D. Dalam aplikasi ini terdapat objek mata 3 dimensi yang dibuat dengan menggunakan aplikasi Blender, dengan Unity sebagai game engine dan Vuforia sebagai library. Cara menggunakanya dengan mengarahkan kamera pada marker yang telah tersedia. Kemudian akan muncul gambar 3 dimensi pada layar smartphone beserta penjelasannya. Media pembelajaran biologi tentang mata dengan menggunakan Augmented Reality lebih mudah dipahami dari pada menggunakan gambar 2 dimensi. Karena siswa dapat melihat bentuk bola mata secara nyata dalam bentuk 3 dimensi.
O uso da fisioterapia em cães com displasia coxofemoral
Authors: Silva Letícia Cristiane da , Pereira Lohanna Serafini Campos , Pacheco Larissa Teixeira 
Published: July 2022

O presente trabalho busca apresentar um artigo experimental sobre o tratamento da displasia coxofemoral em cães, enfatizando os tratamentos conservativos, em especial as modalidades de reabilitação veterinária disponíveis. Foram selecionados 12 animais que foram divididos igualmente em dois grupos de forma aleatória, no grupo I os 6 animais selecionados foram tratados apenas com terapias medicamentosas e no grupo II, os 6 animais foram tratados com terapias medicamentosas e integrativas. Os grupos foram submetidos a avaliações a curto e longo, avaliando os sinais de Ortolani, Barlow e Bardens antes e após o início do tratamento. No momento zero nenhum dos animais selecionados apresentaram superioridade estatísticas nas três variáveis avaliadas. Na primeira avaliação, com 30 dias de tratamento, não houve diferença estatística em nenhuma das variáveis nos dois grupos, indicando que em ambas terapias o período de 30 dias é curto para promover melhoras significativas nas variáveis avaliadas. Na avaliação a longo prazo após pelo menos 60 dias de tratamento, os ângulos de flexão e extensão e diâmetro da coxa do grupo II apresentaram evolução significativa comparado às avaliações anteriores, enquanto que no grupo I não foram observadas quaisquer alterações. Tais resultados indicam que a fisioterapia foi mais eficiente em melhorar a amplitude articular e promover ganho muscular, quando comparado à terapia medicamentosa, porém, é preciso levar em conta que a fisioterapia promove rápido ganho muscular quando comparado à terapia convencional.
Calcium Phosphate/Hyaluronic Acid Composite Hydrogels for Local Antiosteoporotic Drug Delivery
Authors: Svarca Alise , Grava Andra , Dubnika Arita , Ramata-Stunda Anna , Narnickis Raimonds , Aunina Kristine , Rieksta Eleonora , Boroduskis Martins , Jurgelane Inga , Locs Janis , Loca Dagnija 
Published: July 2022

Despite the bone ability of self-regeneration, large bone defects require surgical intervention. Likewise, when it comes to osteoporotic bone fractures, new approaches should be considered a supportive mechanism for the surgery. In recent years, more and more attention has been attracted to advanced drug delivery systems for local osteoporosis treatment, combining appropriate biomaterials with antiosteoporotic drugs, allowing simultaneously to regenerate the bone and locally treat the osteoporosis. Within the current research, hyaluronic acid/strontium ranelate (HA/SrRan), HA/calcium phosphate nanoparticles (HA/CaP NPs), and HA/CaP NPs/SrRan hydrogels were prepared. The effect of CaP and SrRan presence in the composites on the swelling behavior, gel fraction, molecular structure, microstructure, and SrRan and Sr2+ release, as well as in vitro cell viability was evaluated. Obtained results revealed that the route of CaP nanoparticle incorporation into the HA matrix had a significant effect on the hydrogel gel fraction, rheological properties, swelling behavior, and microstructure. Nevertheless, it had a negligible effect on the release kinetics of SrRan and Sr2+. The highest cell (3T3) viability (&gt;80%) was observed for HA hydrogels, with and without SrRan. Moreover, the positive effect of SrRan on 3T3 cells was also demonstrated, showing a significant increase (up to 50%) in cell viability if the used concentrations of SrRan were in the range of 0.05–0.2 μg/ml.
Biomechanical Comparison Between Porous Ti6Al4V Block and Tumor Prosthesis UHMWPE Block for the Treatment of Distal Femur Bone Defects
Authors: Zhang Jiangbo , Liu Yang , Han Qing , Zhang Aobo , Chen Hao , Ma Mingyue , Li Yongyue , Chen Bingpeng , Wang Jincheng 
Published: July 2022

Purpose: The management of bone defects is a crucial content of total knee revision. This study compared the biomechanical performance of porous Ti6Al4V block and tumor prosthesis UHMWPE block in treating distal femoral bone defects.Methods: The finite element models of AORI type 3 distal femoral bone defect treated with porous Ti6Al4V block and UHMWPE block were established. Sensitivity analysis was performed to obtain the appropriate mesh size. The biomechanical performance of treatment methods in bone defects were evaluated according to the peak stress, the Von Mises stress distribution, and the average stresses of regions of interest under the condition of standing on one foot and flexion of the knee. Statistical analysis was conducted by independent samples t-test in SPSS (p &lt; 0.05).Results: In the standing on one-foot state, the peak stress of the porous Ti6Al4V block was 12.42 MPa and that of the UHMWPE block was 19.97 MPa, which is close to its yield stress (21 MPa). Meanwhile, the stress distribution of the UHMWPE block was uneven. In the flexion state, the peak stress of the porous Ti6Al4V block was 16.28 MPa, while that of the UHMWPE block was 14.82 MPa. Compared with the porous Ti6Al4V block group, the average stress of the region of interest in UHMWPE block group was higher in the standing on one foot state and lower in the flexion state (p &lt; 0.05).Conclusion: More uniform stress distribution was identified in the porous Ti6Al4V block application which could reserve more bone. On the contrary, uneven stress distribution and a larger high-stress concentration area were found in the UHMWPE block. Hence, the porous Ti6Al4V block is recommended for the treatment of AORI type 3 distal femoral bone defect.
Risk of Ischemic Bowel Disease in Patients With Atrial Fibrillation Receiving Warfarin or Non-vitamin K Antagonist Oral Anticoagulants
Authors: Liao Jo-Nan , Chan Yi-Hsin , Kuo Ling , Tsai Chuan-Tsai , Lim Su-Shen , Chao Tze-Fan 
Published: July 2022

BackgroundAlthough atrial fibrillation (AF) is a risk factor for ischemic bowel disease, data regarding the incidence of ischemic bowel disease in patients with anticoagulated AF were limited.MethodsThe present study used the Taiwan NHIRD and included newly diagnosed patients with AF aged ≥ 20 years without ischemic bowel disease from 2012 to 2018. A total of 69,549 patients taking warfarin or non-vitamin K antagonist oral anticoagulants (NOACs) constituted the final study group. We aimed to study the incidence of ischemic bowel disease in patients with AF receiving warfarin or NOACs. Secondary endpoints were also analyzed, including ischemic stroke, systemic embolism, myocardial infarction, mortality, intracranial hemorrhage (ICH), major bleeding, and composite adverse events (ischemic bowel disease or ICH or major bleeding).ResultsThere were 43,787 patients taking NOACs and 25,762 patients taking warfarin. The overall incidence rate of ischemic bowel disease was 0.036% per year and increased with the CHA2DS2-VASc scores [0.013% for patients with a CHA2DS2-VASc score of 0 (men) or 1 (women), 0.022% for those with a CHA2DS2-VASc score of 1 (men) or 2 (women), and 0.039% for those with a CHA2DS2-VASc score ≥ 2 (men) or ≥ 3 (women)]. The risk of ischemic bowel disease was similar between NOAC and warfarin groups (0.036%/year vs. 0.037%/year; adjusted hazard ratio 0.802, p = 0.430), whereas the NOAC group had a significantly lower risk of secondary endpoints compared to the warfarin group.ConclusionWe reported the incidence of ischemic bowel disease in patients with anticoagulated AF from a nationwide cohort database and observed a positive correlation between the increase of CHA2DS2-VASc scores and the incidence rate. Moreover, NOAC was as effective as warfarin for the risk of ischemic bowel disease.
Comparison of Influence of Blood Pressure and Carotid-Femoral Pulse Wave Velocity on Target Organ Damage in Hypertension
Authors: Chao Huijuan , He Yan , Wang Qian , Bai Yaya , Avolio Alberto , Deng Xueqin , Zuo Junli 
Published: July 2022

ObjectivesAssessment of target organ damage (TOD) is an important part of the diagnosis and evaluation of hypertension. Carotid-femoral pulse wave velocity (cf-PWV) is considered to be the gold-standard for noninvasive arterial stiffness assessment. This study aims to analyze the risk of TOD in people with different phenotypes of peripheral blood pressure and cf-PWV.MethodsThe study cohort was recruited from December 2017 to September 2021 at Ruijin Hospital in Shanghai. It was divided into 4 groups according to peripheral blood pressure (pBP) and cf-PWV. TOD was assessed as carotid intima-media thickness (CIMT), chronic kidney disease (CKD), urinary albumin-creatinine ratio (ACR), estimated glomerular filtration rate (eGFR) and left ventricular mass index (LVMI).ResultsA total of 1,257 subjects (mean age 53.13 ± 12.65 years, 64.2% males) was recruited. Age, body mass index (BMI) and fasting blood glucose (FBG), as well as peripheral systolic blood pressure (pSBP), peripheral diastolic blood pressure (pDBP), peripheral pulse pressure (pPP) were significantly different in the four groups (P &lt; 0.01). eGFR, ACR, LVMI and CIMT were significantly different among different groups (P &lt; 0.01). The risk of ACR abnormality was significantly higher in the group with elevated pBP (P = 0.005, OR 2.264, 95%CI 1.277–4.016; and in the group with elevated pBP and cf-PWV (P = 0.003, OR 1.482, 95%CI 1.144–1.920), while left ventricular hypertrophy (LVH) was significantly higher in the group with elevated cf-PWV (P = 0.002, OR 1.868, 95%CI 1.249–2.793).ConclusionDifferent profiles based on the status of PBP and cf-PWV associated with different TOD. Individuals with higher pBP have an increased risk of ACR abnormality, while individuals with only cf-PWV elevated have a higher risk of LVH.
Association of Sarcopenia and A Body Shape Index With Overall and Cause-Specific Mortality
Authors: Qiao Yu-Shun , Tang Xingyao , Chai Yin-He , Gong Hong-Jian , Zhang Xin , Stehouwer Coen D. A. , Zhou Jian-Bo 
Published: July 2022

AimThis observational study aimed to examine the association between the A Body Shape Index (ABSI) and/or sarcopenia and total, cardiovascular, and cancer mortality.MethodsThe associations of sarcopenia and ABSI with all-cause, cardiovascular, and cancer mortality were assessed in 4,488 participants from the 1999–2004 National Health and Nutrition Examination Survey (NHANES) who were followed up until December 31, 2015. Models were analyzed separately for men and women and adjusted for age, race, and other confounding factors. ABSI was assessed as a continuous measurement by quartile for men and women. Population attributable fractions (PAFs) were calculated to assess mortality caused by sarcopenia and/or ABSI in the study population.ResultsWhen ABSI was assessed as a continuous variable, the ABSI quartile showed a linear trend for total (p = 0.0001), cardiovascular (p = 0.04), and cancer (p = 0.02) mortality in men and for total (p = 0.06) and cardiovascular (p = 0.06) mortality in women. The hazard ratios (HRs) of the fourth ABSI quartile were 1.51 [95% confidence interval (CI): 1.20–1.89] in men and 1.23 (95% CI: 0.93–1.64) in women, compared with those in the first quartile. When ABSI was assessed by quartile, the appendicular skeletal mass index (ASMI) was lower in the groups with high ABSI. When high ABSI was combined with sarcopenia, the HRs of all-cause mortality were 2.05 (95% CI: 1.60–2.62) in men and 1.51 (95% CI: 1.19–1.92) in women. In the subpopulation (sarcopenia group or higher ABSI), the PAFs of mortality due to sarcopenia were 26.16% (95% CI: 12.68–37.56) in men and 21.89% (95% CI: 5.64–35.35) in women, and the PAF of mortality due to higher ABSI was 23.70% (95% CI: 12.11–33.77) in men.ConclusionThe ABSI value was significantly associated with all-cause and cardiovascular mortality, and the co-existence of higher ABSI values and sarcopenia can contribute to a more significant death risk in comparison with high ABSI values or sarcopenia. Moreover, the ABSI values in combination with the ASMI can be used to preliminarily evaluate the content and distribution of fat and muscle and to predict the risk of death in obese and sarcopenic populations.