bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of fluid absorption and plasma volume changes in athletes following consumption of various beverages
Authors: Yun Hyo-Jun , Lee Ji-Yong , Jeon Minsoo , Oh Sang-eun , Park Jae-Hyeon , Yoon Jiwun 
Published: December 2022

Abstract
Background
To verify the hydration effects of oral rehydration solution (ORS) on athletes by comparing the degrees of fluid absorption and plasma volume changes following beverage consumption, including ORS.

Methods
Thirty-one participants visited the testing laboratory 4 times at 1-week intervals to consume 1 L of beverage (e.g., water, ORS, and two sports drinks [SpD]) for 30 min on each visit. The urine output was measured 4 times at 1 h, 2 h, 3 h, and 4 h after beverage consumption. A blood sample was collected 3 times at 1 h, 2 h, and 3 h after beverage consumption. Body weight was measured once in 4 h after beverage consumption.

Results
Body weight change was smaller for ORS than for water, SpD1, and SpD2 (p < 0.05). Cumulative urine output in 4 h was lower for ORS, SpD1, and SpD2 than for water (p < 0.05), and it was lower for ORS than for SpD2 (p < 0.05). BHI in 4 h was higher for ORS, SpD1, and SpD2 than for water (p < 0.05), and it was higher for ORS than for SpD2 (p < 0.05). There was no significant difference in PVC for different beverages at all test times, i.e.., 1 h, 2 h, and 3 h.

Conclusions
We evaluated the hydration effects of the consumption of beverages, such as water, SpD, and ORS in athletes. ORS and SpD were more effective than water. A comparison between ORS and SpD showed that the result could vary depending on the type of SpD.
Evaluation of novel surfactants for plant transformation
Authors: Huynh Jennie , Hotton Sara K. , Chan Ron , Syed Yasra , Thomson James 
Published: December 2022

Abstract
Objective
Assess the efficiency of seven novel surfactants, relative to the typical Silwet® L-77, for floral dip transformation of Arabidopsis.

Results
Floral dip transformation of Arabidopsis has been used consistently for 20 years with little change in the protocol. Here we directly compare seven novel surfactants (BREAK-THRU®-OE446, S200, S233, S240, S279, S301 and SP133) to the standard Silwet® L-77 for efficiency of Arabidopsis transformation providing an example of how the surfactants can help other plant transformation protocols. Relative transformation efficiencies ranged from − 44 to + 45% compared to Silwet® L-77. Surfactants S200, S240, and S279 demonstrated the greatest enhancement in transformation.
DAD3 targets ACE2 to inhibit the MAPK and NF-κB signalling pathways and protect against LPS-induced inflammation in bovine mammary epithelial cells
Authors: Zhang Xiangjun , Jia Fang , Ma Weiwu , Li Xueqiang , Zhou Xuezhang 
Published: December 2022

AbstractThe protective arm of the renin-angiotensin system (RAS), the ACE 2/Ang-(1–7)/MasR axis, has become a new anti-inflammatory target. As a specific activator of ACE2, diminazene aceturate (DA) can promote anti-inflammatory effects by regulating the ACE2/Ang-(1–7)/MasR axis. However, due to the reported toxicity of DA, its application has been limited. In the current study, we synthesized a low toxicity DA derivative 3 (DAD3) and sought to determine whether DAD3 can also activate ACE2 in bovine mammary epithelial cells (BMEC) and regulate the RAS system to inhibit inflammation. We found that both DA and DAD3 can activate and promote ACE2 expression in BMEC. iRNA-mediated knockdown of ACE2 demonstrated that DAD3 activates the ACE2/Ang-(1–7)/MasR axis and plays an anti-inflammatory role in BMEC. Furthermore, the inhibitory effects of DA and DAD3 on the protein phosphorylation of MAPK and NF-κB pathways were reduced in ACE2-silenced BMEC. Our findings show that ACE2 is a target of DAD3, which leads to inhibition of the MAPK and NF-κB signalling pathways and protects against LPS-induced inflammation in BMEC. Thus, DAD3 may provide a new strategy to treat dairy cow mastitis.
Physical climate change and the sovereign risk of emerging economies
Authors: Boehm Hannes 
Published: December 2022

AbstractI show that rising temperatures can detrimentally affect the sovereign creditworthiness of emerging economies. To this end, I collect long-term monthly temperature data of 54 emerging markets. I calculate a country’s temperature deviation from its historical average, which approximates present-day climate change trends. Running regressions from 1994m1 to 2018m12, I find that higher temperature anomalies lower sovereign bond performances (i.e., increase sovereign risk) significantly for countries that are warmer on average and have lower seasonality. The estimated magnitudes suggest that affected countries likely face significant increases in their sovereign borrowing costs if temperatures continue to rise due to climate change. However, results indicate that stronger institutions can make a country more resilient towards temperature shocks, which holds independent of a country’s climate.
Statistical study on the regional characteristics of seismic activity in and around Japan: frequency-magnitude distribution and tidal correlation
Authors: Nagata Kohei , Tamaribuchi Koji , Hirose Fuyuki , Noda Akemi 
Published: December 2022

AbstractWe propose a statistical analysis method to identify common features of seismic activity that are indistinguishable from most other seismicity, and to find anomalous activity that differs from these common features. Using the hypocenter catalog of earthquakes which occurs in and around Japan during the past 20 years, we apply this method for the parameters of the frequency-magnitude distribution and a parameter that expresses the correlation of seismicity with tides as indices, with a focus on objectively understanding the regional characteristics of seismicity. As a result, we extracted a "typical" probability density distribution of each index value common to the most analysis regions and "anomalous" regions with index-value distributions that differ significantly from the typical distributions. In terms of the frequency-magnitude distribution, most estimated values of indices in the anomalous activity areas can be explained as variations corresponding to the effects of fluids, interplate coupling, and stress fields that control faulting styles that have been pointed out in previous studies. By extracting typical index values for the frequency-magnitude distribution, common features of the frequency-magnitude distribution that depend on the earthquake occurrence interval were identified. Although seismicity showed no clear correlation with tides, the index value for tidal correlation changes to reflect the proportion of earthquakes occurring in a series of periods shorter than the tidal period; it is therefore useful as an index to capture the characteristics of such earthquake occurrence intervals. We also show that the typical probability density distribution of these index values can be represented by existing models or their extensions. By using the proposed models as a reference, it is possible to quantify the degree of anomaly using the same concept as that of the method presented here; hence, such a method should be applicable to monitor seismic activity.
Graphical Abstract
Hard and soft tissue evaluation of alveolar ridge preservation compared to spontaneous healing: a retrospective clinical and volumetric analysis
Authors: De Angelis Paolo , De Rosa Giuseppe , Manicone Paolo Francesco , De Giorgi Alessandro , Cavalcanti Camilla , Speranza Alessandro , Grassi Roberta , D’Addona Antonio 
Published: December 2022

AbstractPurposeThe remodeling process following tooth extraction can be observed as horizontal and vertical bone reduction of the alveolar ridge. Preservation procedures such as alveolar ridge preservation (ARP) aim to maintain the 3D volume of the extraction site. This retrospective study analyzed differences in the hard and soft tissue changes in patients treated with either spontaneous healing or ARP.MethodsAfter tooth extraction, the patients were treated either by spontaneous socket healing (SH group) or with ARP using a xenograft and a resorbable membrane (ARP group). One week before and 6 months after extraction, the patients underwent cone beam computed tomography. A volumetric analysis was performed by superimposing the digital models of the two time points. Intraoral radiography was performed after implant placement, upon prosthesis delivery, and at 1-year post-treatment. An esthetic assessment was conducted using the Pink Esthetic Score (PES). The patients’ overall satisfaction with the implant restoration was investigated at 12 months.ResultsIntragroup comparisons revealed significant differences between baseline and the 6-month follow-up in both groups at the measured locations (1 mm, 3 mm, and 5 mm below the most coronal aspect of the alveolar ridge) showing a reduction of the horizontal width (P < 0.05). Additionally, after treatment, the horizontal width at 1 mm was significantly different in the SH and ARP groups (P < 0.001), with mean changes of 2.03 ± 0.54 mm and 0.86 ± 0.49 mm, respectively. ARP was associated with an increased PES (11.6 ± 2.2) and a reduction in patients requiring additional grafting procedures in subsequent treatment phases (9% vs 26%;P = 0.11).ConclusionsIn both groups, significant horizontal and vertical bone loss was observed after the extraction. ARP can reduce linear and volumetric shrinkage of the alveolar ridge, leading to improved outcomes. It can also simplify implant restoration.Graphical Abstract
Maintenance issues of elderly patients requiring nursing care with implant treatments in dental visiting: position paper
Authors: Ohkubo Chikahiro , Ikumi Noriharu , Sato Yuji , Shirai Mai , Umehara Kazuhiro , Ohashi Isao , Shibagaki Hirokazu , Niki Yoshimine , Masaki Chihiro , Mikami Itaru , Murakami Hiroshi , Yoshinaga Osamu , Wada Masahiro , Watanabe Fumihiko 
Published: December 2022

Abstract
Purpose
Japan, with an increasing number of elderly people needing long-term care in a super-aged society, urgent needs to develop the clinical guidelines on implant maintenance for elderly people with declining independence. The purpose is to categorize the troubles encountered in the care of patients with dental implants and to indicate actual practices and points of note.

Methods
From the members of the Japanese Society of Oral Implantology, 12 expert panelists who were experienced with many problems of implant maintenance during dental visits and were familiar with their solutions were selected. Through repeated discussions in the many panel meetings, the problems of implant maintenance during dental visits were distilled.

Results
During a dental visit, the oral cavity, general conditions, and background of elderly patients who cannot orally care for themselves must be grasped, and medical staff, care managers, and patients should understand the changes in these factors as time goes by. The solutions and responses that can be made differ greatly depending on the medical care facilities, the environment, differences in the experience of medical staff, and the patient’s background. Thus, it is necessary to select safe treatments appropriate to each situation.

Conclusions
This paper features many opinions based on clinical experiences. However, clinical guidelines on implant management during dental visits should be formulated in the future based on the accumulation of evidence through the implementation of clinical research.
Consensus and Controversial Aspects of Vitamin D and COVID-19
Authors: Bilezikian John P , Binkley Neil , De Luca Hector F , Fassio Angelo , Formenti Anna Maria , El-Hajj Fuleihan Ghada , Heijboer Annemieke C , Giustina Andrea 
Published: December 2022

AbstractObjectiveThis work aims to review and discuss controversial topics in the field of vitamin D, SARS-CoV-2 infection, and COVID-19.MethodsThe International Conferences “Controversies in Vitamin D” are a series of workshops that started in 2017 featuring international experts and leaders in vitamin D research and clinical practice. The fifth annual conference was held in Stresa, Italy, September 15 to 18, 2021.EvidenceBefore the event, participants reviewed available studies on their assigned topic, drafted a related abstract, and presented their findings at the time of the conference. Relevant literature that became available since was also discussed within the panel and updated accordingly.ConsensusBefore the event, the drafted abstracts had been merged to prepare a preliminary document. After the conference presentations, in-depth discussions in open sessions led to consensus. The document was subsequently modified according to discussions and up-to-date literature inclusion.ConclusionsThere is quite consistent evidence for an association between low 25 OH vitamin D (25(OH)D) levels and poor COVID-19 outcomes, despite heterogeneous publications of variable quality. However, the low vitamin D status in COVID-19 patients might also reflect reverse causality. Vitamin D supplementation might have a positive role in COVID-19 prevention. The evidence supporting a beneficial effect of vitamin D treatment in decreasing the risk of COVID-19 complications is conflicting. Conclusive statements regarding the beneficial effect of vitamin D in this context await high-quality, randomized controlled trials.
Preterm Birth and Corticotrophin-Releasing Hormone as a Placental Clock
Authors: Herrera Christina L , Maiti Kaushik , Smith Roger 
Published: December 2022

Abstract
Preterm birth worldwide remains a significant cause of neonatal morbidity and mortality, yet the exact mechanisms of preterm parturition remain unclear. Preterm birth is not a single condition, but rather a syndrome with a multifactorial etiology. This multifactorial nature explains why individual predictive measures for preterm birth have had limited sensitivity and specificity. One proposed pathway for preterm birth is via placentally synthesized corticotrophin-releasing hormone (CRH). CRH is a peptide hormone that increases exponentially in pregnancy and has been implicated in preterm birth because of its endocrine, autocrine, and paracrine roles. CRH has actions that increase placental production of estriol and of the transcription factor nuclear factor-κB, that likely play a key role in activating the myometrium. CRH has been proposed as part of a placental clock, with early activation of placental production resulting in preterm birth. This article will review the current understanding of preterm birth, CRH as an initiator of human parturition, and the evidence regarding the use of CRH in the prediction of preterm birth.
COVID-19 among Indonesian ENT specialist and resident after second dose of Sinovac vaccination
Authors: Zachreini Indra , Bashiruddin Jenny , Tamin Susyana , Priyono Harim , Mayangsari Ika Dewi , Supartono Natasha , Diksita Anggina , Ranakusuma Respati Wulansari , Dewi Yussy Afriani , Indrasari Sagung Rai , Purnami Nyilo , Haryuna Tengku Siti Hajar , Harahap Juliandi , Savitri Eka , Manukbua Tjandra 
Published: December 2022

Background: The purpose of this study was to obtain data on the prevalence of specialist doctors and Otorhinolaryngology-Head and Neck Surgery (ORL-HNS) residents in Indonesia who suffered from Coronavirus disease 2019 (COVID-19) after receiving the second dose of COVID-19 vaccination using the Sinovac vaccine (CoronaVac) and the length of time infected with COVID-19 after the second Sinovac vaccination. Methods: We performed a descriptive observational study, using a cross-sectional design. Data collection took place between August 2021 and October 2021. The respondents in this study included specialist doctors and ORL-HNS residents who worked in various hospitals in Indonesia who had received the second dose of the Sinovac vaccination. Data collection was performed by means of Self-reporting Online Survey Platform (Google Form). Results: This study included 1,530 respondents, and 54.2% of respondents were women. Respondents consisted of 68.6% ORL-HNS doctors and the rest were residents with an average age of 41.46 years old. The distance between the first and second doses of Sinovac was mostly under one month, which was 71.3% of the respondents. A total of 76.3% of respondents did not have co-morbid diseases. Based on this study, 16.9% of respondents suffered from COVID-19 after the second dose of Sinovac vaccination. The length of time suffering from COVID-19 after the second Sinovac vaccination was 3-6 months (9.7%). Conclusions: Based on this study, 16.9% of respondents suffered from COVID-19 after receiving the second Sinovac vaccination and 9.7% suffered from COVID-19 after 3-6 months of Sinovac vaccination.
Trends in frailty and its associated factors in the community dwelling elderly Indian population during the COVID-19 pandemic: A prospective analytical study
Authors: Gautam Karan , Krishnan K Shyam , Kumar K Vijaya , Nayak Megha M 
Published: December 2022

Background: There is a scarcity of quality literature on the prevalence of frailty among community dwelling elderly in India. This study was originally planned to analyze the longitudinal trends in frailty status of community dwelling elderly in an Indian population as well to identify factors associated with frailty in the Indian context. However, the recruitment phase of this study coincided with one of the largest lockdowns in history, associated with the COVID-19 pandemic, and this gave us a unique opportunity to study the effects this pandemic enforced, as a result of the necessary restrictions, on the frailty status as well the factors affecting frailty in the elderly. Methods: A prospective observational study was designed and conducted amongst 19 community dwelling elderly of Dakshina Kannada District, in Karnataka India. Outcome variables of frailty (EFIP), physical activity (PASE), functional mobility (TUG), gait speed (10-meter walk test), nutritional status (MNA®-SF) body composition (BIA), and strength (dynamometry), were measured at baseline and on follow-up after three months. The changes occurring in these variables over the three-month period were analyzed and the change in frailty was independently correlated with changes in each of the other outcomes. Results: We couldn’t identify any statistically significant difference in frailty over a period of three months. However, there was a highly significant change in the physical activity status, lower extremity muscle strength, body composition, functional mobility, gait speed, and cognitive function in the same time period. Conclusions: Though individual determinants of frailty in community dwelling changed over a three-month period, these changes failed to produce any observable/measurable difference in frailty status.
Development, dissemination and evaluation of a smartphone-based app for pressure ulcer/injury prevention and treatment for use at the bedside
Authors: Cuddigan Janet , Haesler Emily , Moore Zena , Carville Keryln , Kottner Jan 
Published: December 2022

Objective: After launching the 2019 International Pressure Ulcer/Injury Guideline, the National Pressure Injury Advisory Panel (NPIAP), the European Pressure Ulcer Advisory Panel (EPUAP) and the Pan Pacific Pressure Injury Alliance (PPPIA) collaborated with Sensorydata Corp., US, to develop a guideline app (InterPIP App). The app was designed to: present evidence-based guideline recommendations; incorporate search capacities and functionality to facilitate easy access to clinical guidance; provide accessibility in multiple languages; and to be available worldwide at a reasonable price, including opportunities for free access in low-resource countries. This paper describes the development, dissemination and formative evaluation of a mobile app providing evidence-based recommendations for pressure injury prevention, assessment/classification, and treatment at the point of care. Method: An evaluation tool was designed based on a framework developed by Nouri et al. and made available to all app subscribers. Results: The InterPIP App is currently available in 11 languages and had been downloaded 3616 times by February 2022 in 78 countries. A total of 62 individuals responded to the survey of end-users. In this formal evaluation of user experiences, the app was rated positively on criteria of: information/content; usability; design; functionality; ethics; and security/privacy (median=4 on a 1–5 Likert scale). Overall perceived value was ranked lower with a median of three. Users provided suggestions for ongoing app enhancement. Conclusion: The InterPIP App offers a unique opportunity to bring evidence-based guidance to the point of care. Formal evaluation of end-user experiences identified opportunities for quality improvement, and informed plans for future development and evaluation.
Terahertz antenna with tunable filtering
Authors: Ali Mohd Farman , Jawed Zaid , Raj Vinamra , Varshney Gaurav 
Published: December 2022

A terahertz (THz) antenna with tunable filtering is designed and numerically studied. A
slotted monopole radiator with defected ground structure is used for
operating with wideband response with an impedance bandwidth in the
range of 3.80–11.98 THz for

S

11

≤
−
10

d
B

. A slot is engraved in the radiator
for obtaining the filtering characteristics in the antenna response.
By varying its chemical potential, the frequency band
5.05–6.69 THz with graphene material can provide the tunability
in the frequency and bandwidth of the filtered band in the antenna
response. Furthermore, the antenna can provide radiation efficiency of
more than 90% and gain with a peak value of 6.6 dBi in the
passband.