bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cianeto de Mandioca: viabilidade econômica do uso de manipueira para erradicação do mercúrio na mineração, e proposta para Bioeconomia Circular na Amazônia, Brasil
Authors: Lima Rodrigo Gonçalves de , Silva Renato Barboza da , Lima Helledsen Ramos da Silva de , Hanada Rogério Eiji , Azevedo João Lúcio de 
Published: June 2022

A mineração artesanal de ouro é uma atividade mundial que inclui cerca de 20 milhões de garimpeiros e produz até 450 toneladas/ano.O mercúrio é o principal reagente para extração de ouro em explorações artesanais, mas seu uso indevido pode contaminar o meio ambiente. Ao contrário do mercúrio, o cianeto (CN) pode é volátil e não oferece risco de acúmulo ambiental. Novas tecnologias vêm sendo pesquisadas para a erradicação do mercúrio na mineração, e produzir “cianeto verde” de origem natural a partir da mandioca para substituir o uso do mercúrio na mineração, esta contém glicosídeos que gera cianeto e que podem ser usados para lixiviar o ouro (derreter o ouro), transformando-a na forma iônica para posterior recuperação com o uso do carvão ativado e eletrólise. O objetivo deste estudo foi mostrar a distribuição da produção de mandioca no Brasil, realizar breve consideração sobre os produtos gerados e apresentar suas potencialidades no uso regional do Amazonas, para tal foi feito busca de dados da produtividade da mandiocultura no Brasil em repositórios de órgão públicos oficiais, compilado os dados e apresentado os resultados, tendo como principais conclusões que: É possível encontrar de forma abundante produtos cianogênicos em (caule, folhas e raízes) de mandioca – planta comestível da Amazônia, e gerar de 111 a 334 mil toneladas de CN-, Novos modelos econômicos podem contribuir para sintetizar produtos de alto valor tecnológico agregado na indústria ou agronegócio da mandiocultura e geração de renda para os amazônidas, principalmente para os amazonenses.
Força isocinéticas do joelho de adultos com paralisia cerebral e de pessoas sem deficiência: uma revisão integrativa de literatura
Authors: Macedo Osmair Gomes de , Vieira Filomena , Gorla José Irineu , Cunha Carlota Leão da , Garcia Patrícia Azevedo , Mota Jorge , Corredeira Rui 
Published: June 2022

Objetivo: Verificar as evidências apresentadas por estudos anteriores que compararam a força isocinética dos músculos que movem o joelho de adultos com PC com grupos controles ou com valores de referência de pessoas sem deficiência física. Método: Foram realizados levantamentos bibliográficos nas bases de dados: PubMed, LILACS, Cochrane Central Register of Controlled Trials (CENTRAL), Physiotherapy Evidence Database (PEDro) e SciELO, foram pesquisados artigos publicados desde o início de cada base de dados até janeiro de 2022. Os termos utilizados para a busca foram “paralisia cerebral”; “adulto”; “isocinético” ou “isocinética”; “dinamômetro” ou “dinamometria”; “joelho”, em português e inglês. Resultados: Foi encontrado o total de 69 artigos na busca inicial (PubMed= 34, LILACS=12, Cochrane CENTRAL= 8, PEDro= 9 e SciELO= 6). Após a remoção das duplicatas permaneceram 46 estudos. Na primeira triagem pelo título e resumo foram selecionados 11 estudos. Após a leitura na íntegra e aplicados os critérios de elegibilidade restaram um total de 4 artigos. Considerações finais: Os estudos relatam que a maioria dos parâmetros de capacidade física pode ser avaliada de forma viável e confiável em adultos com PC com GMFCS níveis I e II, que adultos com PC apresentam menor da força isocinética e isométrica de extensão que adultos sem PC, que jogadores de futebol com PC e hemiparesia apresentaram menor pico de torque e de potência média no lado envolvido, apresentaram valores de pico de torque mais baixos do que os valores previstos para indivíduos sem deficiência física e apresentaram equilíbrio muscular entre flexores e extensores do joelho.
Benefícios da creatina na performance e desenvolvimento da força muscular
Authors: Avelino José Matheus Garcia , Ferreira José Carlos de Sales 
Published: June 2022

Introdução: Atualmente a procura de suplementos para o aumento do desempenho físico tem crescido bastante, em vista disto a Creatina (Cr), é um suplemento que se tornou um dos recursos ergogênicos nutricionais mais utilizados nas últimas décadas. Isso ocorreu devido a uma possível melhora no rendimento esportivo ou em treinos de academia. Metodologia: De caráter descritivo onde busca-se destacar acerca dos benefícios e malefícios do uso da creatina no treinamento de força e na melhoria do condicionamento físico registrados na literatura nacional. Resultado e Discussões: A suplementação com creatina é um recurso ergogênico que vem sendo utilizado para melhorar o desempenho esportivo e a força muscular em exercícios de alta intensidade. No entanto, seus efeitos sobre a melhora da força muscular ainda vem sendo motivo de muita discussão entre os pesquisadores. Conclusão: Desta forma, a suplementação adequada quanto ao profissional prescritor e quantidades prescritas, podem promover aos indivíduos benefícios físicos, como: aumento da força máxima, da potência e da resistência muscular, da coordenação motora, da velocidade, da agilidade, do equilíbrio e a prevenção e lesões que em conjunto a atividades que exigem força e alta intensidade, sendo então, um potencial para o aumento de massa corporal. Sendo assim, conclui-se que a suplementação de creatina no treinamento de força de forma adequada, com a ajuda do nutricionista e do educador físico, exerce efeitos que podem contribuir em treinamentos periodizados de força melhorando o desempenho da força muscular e na massa magra.
Análise sobre a percepção dos pedestres quanto as condições de acessibilidade e mobilidade urbana dos passeios e calçadas do município de Abaetetuba, Pará, Brasil
Authors: Carvalho Regiana Barbosa , Silva Jeremias Caetano da , Castro Denys Roberto Corrêa 
Published: June 2022

As calçadas e passeios devem garantir o deslocamento das pessoas com autonomia, independente das suas limitações, sendo necessário apresentar condições de fluidez, conforto e segurança. As barreiras físicas tendem a diminuir as condições de acessibilidade em calçadas e passeios, ocasionando dificuldade para a realização de deslocamento, principalmente a pessoas com mobilidade reduzida. No município de Abaetetuba, Pará, a problemática da mobilidade urbana relacionada aos logradouros públicos é comum. O presente trabalho buscou levantar informações quanto a percepção dos usuários de passeios públicos e calçadas no centro urbano do município. Por meio de um questionário semiestruturado, entrevistou-se 95 pessoas, com faixa etária variando de 30 a 89 anos. Observou-se uma grande quantidade de pessoas com idade mais avançada, e que necessitam transitar por esses espaços públicos de forma segura. Além disso, 31,5% dos entrevistados relataram sofrer de alguma limitação física e 56% relataram já terem sofrido algum acidente por conta das más condições de calçadas e passeios públicos. O principal problema relatado pelos entrevistados foi a ocorrênca de calçadas irregulares e/ou com buracos, citado por 81% dos entrevistados. O estudo possibilitou um maior entendimento acerca da percepção dos pedestres quanto aos espaços públicos utilizados, além de indicações que podem balizar decisões do poder público nas tomadas de decisão no momento de concepções e reformas de obras públicas, além de estimular a orientação e a fiscalização de obras privadas.
Peningkatan Mutu Pembelajaran Melalui Penelitian Tindakan Kelas (PTK) dengan Memanfaatkan Teknologi Pada Masa Covid-19 di SD Pangudi Luhur Jakarta Selatan
Authors: Limbong Mesta 
Published: June 2022

Pandemik Covid-19 masih nyata dalam proses kehidupan yang berlangsung. Namun, proses Pendidikan tidak boleh diabaikan hanya karena situasi tersebut. Untuk itu, pelaksanaan Penelitian Tindakan Kelas (PTK) adalah salah satu strategi yang dapat digunakan untuk memberikan nilai plus bagi pelayanan pendidikan dalam berbagai situasi. Untuk itu, pemahaman yang utuh mengenai PTK, dan pemanfaatan digital literasi bagi peningkatan kompetensi profesional guru perlu untuk tetap dikembangkan.
Guru di SD Pangudi Luhur telah melaksanakan PTK. Hasilnya, peningkatan pemahaman mengenai materi pelajaran yang disampaikan untuk topik penambahan, pengurangan soal cerita di kelas 1 SD dengan memanfaatkan media untuk kelas 3 SD dengan quizziz.
Kata kunci: PTK, digital literacy
Pelatihan Pengukuran Antropometri dan Edukasi Gizi Seimbang sebagai Upaya Revitalisasi Posyandu dalam Rangka Menurunkan Angka Stunting di Kelurahan Cawang/Jakarta Timur
Authors: Sormin Elferida , Siagian Carmen 
Published: June 2022

Pengabdian kepada Masyarakat yang dilaksanakan di Kelurahan Cawang dalam bentu kegiatan Pelatihan Pengukuran Antropometri dan Edukasi Gizi Seimbang sebagai Upaya Revitalisasi Posyandu dalam Rangka Menurunkan Angka Stunting, yang diselenggarakan atas dasar adanya kerjasama antara UKI dengan Kelurahan Cawang, masih tingginya angka stunting khususnya di Kelurahan Cawang menarik perhatian banyak kalangan termasuk Universitas Kristen Indonesia. Pusat Studi Pangan dan Gizi yang berada di bawah koordinasi Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UKI melakukan tindakan aktif dan partisipatif sebagai kontribusi nyata dalam upaya penurunan angka stunting. Peran para kader posyandu sebagai garda terdepan dalam pengumpulan data riwayat bayi melalui penguruan antropometri (pengukuran panjang badan dan berat badan) bayi usia di bawah 2 tahun, oleh karena itu kegiatan PkM ini ditujukan kepada para kader posyandu yang dilatih melakukan pengukuran antropometri dengan baik dan benar sehingga dihasilkan data yang valid untuk penentuan status bayi yang sedang diukur. Pengukuran antropometri secara khusus pengukuran panjang badan bayi menggunakan alat yang didesain sendiri oleh Tim PkM yang disebut dengan tikar panjang badan. Setelah mengikuti pelatihan pengukuran antropometri panjang badan menggunakan tikar panjang badan dengan menggunakan praktik langsung, para kader menyatakan ketertarikan mereka menggunakan alat tersebut, karena mudah digunakan/tidak merepotkan pengukur dan tidak menyusahkan anak/bayi (karena anak tinggal ditidurkan saja di atas tikar panjang badan).
Kata Kunci:Stunting; Antropometri; Panjang Badan; Kader Posyandu.
VEGF-Loaded Heparinised Gelatine-Hydroxyapatite-Tricalcium Phosphate Scaffold Accelerates Bone Regeneration via Enhancing Osteogenesis-Angiogenesis Coupling
Authors: Chen Xu , Gao Chun-Yan , Chu Xiao-Yang , Zheng Chun-Yan , Luan Ying-Yi , He Xin , Yang Kai , Zhang Dong-Liang 
Published: June 2022

Background: Bone tissue defect, one of the common orthopaedicdiseases, is traumatizing and affects patient’s lifestyle. Although autologous and xenograft bone transplantations are performed in bone tissue engineering, clinical development of bone transplantation is limited because ofvarious factors, such as varying degrees of immune rejection, lack of bone sources, and secondary damage to bone harvesting.Methods: We synthesised a heparinised gelatine-hydroxyapatite-tricalcium phosphate (HG-HA-TCP) scaffold loaded with sustained-release vascular endothelial growth factor (VEGF) analysed their structure, mechanical properties, and biocompatibility. Additionally, the effects of HG-HA-TCP (VEGF) scaffolds on osteogenic differentiation and vascularisation of stem cells from human exfoliated deciduous teeth (SHED) in vitro and bone regeneration in vivo were investigated.Results: HG-HA-TCP scaffold possessed good pore structure, mechanical properties, and biocompatibility. HG-HA-TCP scaffold loaded with VEGF could effectively promote SHED proliferation, migration, and adhesion. Moreover, HG-HA-TCP (VEGF) scaffold increased the expression of osteogenesis- and angiogenesis-related genes and promoted osteogenic differentiation and vascularisation in cells. In vivo results demonstrated that VEGF-loaded HG-HA-TCP scaffold improved new bone regeneration and enhanced bone mineral density, revealed byhistological, micro-CT and histochemical straining analyses. Osteogenic and angiogenic abilities of the three biological scaffolds wereranked as follows: HG-HA-TCP (VEGF) &gt; G-HA-TCP (VEGF) &gt; G-HA-TCP.Conclusion: HG-HA-TCP (VEGF) scaffold with good biocompatibility could create an encouraging osteogenic microenvironment that could accelerate vessel formation and osteogenesis, providing an effective scaffold for bone tissue engineering and developing new clinical treatment strategies for bone tissue defects.
Research of Synergistic Substances on Tobacco Beetle [Lasioderma serricorne (Fabricius) (Coleoptera: Anobiidae)] Adults Attractants
Authors: Ren Yanling , Wang Tao , Jiang Yingjie , Chen Pengchao , Tang Jian , Wang Juan , Jin Daochao , Guo Jianjun 
Published: June 2022

In this study, four kinds of chemical substances (2,3,5,6-tetramethylpyrazine, β-ionone, citronellal, and paeonol), three kinds of plant essential oils (tea tree essential oil, lavender essential oil, and myrrh essential oil), and their combinations were selected to explore their synergistic effects on tobacco beetle [Lasioderma serricorne (Fabricius) (Coleoptera: Anobiidae)] adults by the behavioral test and laboratory simulation test. Behavioral test results showed that some of the combinations revealed a synergistic effect on tobacco beetle adults, especially the sexual attractant +2,3,5,6-tetramethylpyrazine + β-ionone + citronellal + paeonol (SABCD, one portion of sexual attractant, and 1 mg/L synergistic substances) combination and the food attractant +2,3,5,6-tetramethylpyrazine + paeonol (FAD, 1 ml of food attractant and 1 mg/L synergistic substances) combination showed the best behavioral effect on tobacco beetle adults with average dwell times of 120.97 and 126.74 s, respectively, compared to those of other combinations. Meanwhile, SABCD had the highest selection rate [89.47%, about 1.5 times that of the sexual attractant (S)] on tobacco beetle adults compared with those of other combinations. In addition, laboratory simulation test results showed that the SABCD combination had the highest average selection rate (37.31%, about 2 times that of S) on tobacco beetle adults at 1 mg/L. However, our results showed that there was no significant difference in the indoor simulation results of food attractant synergistic substances. Our results will provide guidance for the development of new pesticides for tobacco beetle adults.
Circular RNAs as Prognostic Biomarkers in Renal Cell Carcinoma: A Systematic Review and Meta-Analysis
Authors: Liao Dan , Lin Qiu , Xiao Huan , Zhang Fenglian , Han Qin 
Published: June 2022

Background: Recently, several studies have shown that circRNAs play critical roles in renal cell carcinoma (RCC) oncogenesis and development. However, whether the level of circRNA expression in RCC is correlated with prognosis remains unclear. Hence, we conducted a meta-analysis to explore the association between circRNA expression levels and the prognosis of RCC patients.Methods: We systematically searched Ovid, Embase, PubMed, and Web of Science from January 1950 to June 2021 for the literature published in English. According to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, we conducted a meta-analysis of 21 selected studies to confirm the association between the circRNA expression level and prognosis of RCC.Results: This meta-analysis included 20 articles and 1,559 RCC patients. The results showed that the high expression of oncogenic circRNAs (OS: HR = 2.04, 95% CI: 1.63–2.56, p = 0.20; PFS: HR = 2.82, 95% CI: 0.82–9.72, p = 0.03) and low expression of tumor-suppressor circRNAs (OS: HR: 1.92, 95% CI: 1.61–2.30, p &lt; 0.05; PFS: HR: 2.40, 95% CI: 1.76–3.28, p = 0.36) were closely related to poor survival outcomes.Conclusion: The meta-analysis verifies that circRNAs can be potential prognostic biomarkers of RCC.
First-Principles Calculations of the Exchange Interaction of the CrGeTe3/NiO Interface
Authors: Liu Xuehua , Li Zhaoyuan , Zhang Whenli , Yao Pei , Zhu Haoran , Liu Xin , Zuo Xu 
Published: June 2022

Two-dimensional (2D) magnetic materials have recently attracted a great attention due to their potential applications in information processing and storage. It was observed in an experiment that the CrGeTe3/NiO heterostructure shows a higher Curie temperature and a stronger perpendicular anisotropy. This suggests that antiferromagnet NiO can be coupled with ferromagnetic CrGeTe3 by the proximity effect, which enhances ferromagnetism. However, the mechanism behind the coupling is unknown. In this work, we built a CrGeTe3/NiO heterostructure model and investigated the electronic structure and magnetic properties of the CrGeTe3/NiO interface by first-principles calculations. It is shown that the intralayer exchange interaction between the Cr atoms is ferromagnetic, and the interlayer exchange interaction between the Ni atoms and Cr atoms at the interface is antiferromagnetic. The interlayer interaction is equivalent to a magnetic field as strong as B=100.3 T applied by the NiO substrate to the CrGeTe3 layer, which results in the higher Curie temperature of CrGeTe3 observed in the experiment.
Epidermal Immunity and Function: Origin in Neonatal Skin
Authors: Visscher Marty O. , Carr Andrew N. , Narendran Vivek 
Published: June 2022

The fascinating story of epidermal immunity begins in utero where the epidermal barrier derives from the ectoderm and evolves through carefully orchestrated biological processes, including periderm formation, keratinocyte differentiation, proliferation, cornification, and maturation, to generate a functional epidermis. Vernix caseosa derives from epidermal cells that mix with sebaceous lipids and coat the fetus during late gestation, likely to provide conditions for cornification. At birth, infants dramatically transition from aqueous conditions to a dry gaseous environment. The epidermal barrier begins to change within hours, exhibiting decreased hydration and low stratum corneum (SC) cohesion. The SC varied by gestational age (GA), transformed over the next 2–3 months, and differed considerably versus stable adult skin, as indicated by analysis of specific protein biomarkers. Regardless of gestational age, the increased infant SC proteins at 2–3 months after birth were involved in late differentiation, cornification, and filaggrin processing compared to adult skin. Additionally, the natural moisturizing factor (NMF), the product of filaggrin processing, was higher for infants than adults. This suggests that neonatal skin provides innate immunity and protection from environmental effects and promotes rapid, continued barrier development after birth. Functional genomic analysis showed abundant differences across biological processes for infant skin compared to adult skin. Gene expression for extracellular matrix, development, and fatty acid metabolism was higher for infant skin, while adult skin had increased expression of genes for the maintenance of epidermal homeostasis, antigen processing/presentation of immune function, and others. These findings provide descriptive information about infant epidermal immunity and its ability to support the newborn’s survival and growth, despite an environment laden with microbes, high oxygen tension, and irritants.
A Novel Score Combining Magnetic Resonance Spectroscopy Parameters and Systemic Immune-Inflammation Index Improves Prognosis Prediction in Non-Small Cell Lung Cancer Patients With Brain Metastases After Stereotactic Radiotherapy
Authors: Guo Dong , Liu Jiafeng , Li Yanping , Chen Qingqing , Zhao Yunzheng , Guo Xinwei , Zhu Shuchai , Ji Shengjun 
Published: June 2022

ObjectiveThe aim of this study was to evaluate the prognostic significance of the combination of the magnetic resonance spectroscopy (MRS) parameters and systemic immune-inflammation index (SII) in patients with brain metastases (BMs) from non-small cell lung cancer (NSCLC) treated with stereotactic radiotherapy.MethodsA total of 118 NSCLC patients with BM who were treated with stereotactic radiotherapy were retrospectively enrolled in this study. All patients underwent MRS and blood samples test for SII analysis before the initiation of stereotactic radiotherapy. The correlation between the parameters of MRS and SII level was assessed using Spearman’s correlation coefficient. The cutoff values for the parameters of MRS, SII, and clinical laboratory variables were defined by the receiver operating characteristic (ROC) curve analysis to quantify these predictive values. The prognostic factors of overall survival (OS) and progression-free survival (PFS) curves were assessed using the Kaplan–Meier and Cox proportional hazards models.ResultsThe median follow-up time was 25 months (range, 12–49 months). The optimal cutoff point for the choline/creatine (Cho/Cr) ratio and SII were 1.50 and 480, respectively. The Cho/Cr ratio was negatively correlated with SII (rs = 0.164, p = 0.075), but there was a trend. The C-SII score was established by combining the Cho/Cr ratio and SII. Patients with both an elevated Cho/Cr ratio (&gt;1.50) and an elevated SII (&gt;480) were given a C-SII score of 2, and patients with one or neither were given a C-SII score of 1 or 0, respectively. The Kaplan–Meier analysis showed that a C-SII score of 2 was significantly linked with poor OS and PFS (p &lt; 0.001 and p &lt; 0.001, respectively). In the Cox proportional hazards model, the C-SII score independently predicted OS [hazard ratio (HR), 1.749; 95% CI, 1.176–2.601; p = 0.006] and PFS (HR, 2.472; 95% CI, 1.624–3.763; p &lt; 0.001).ConclusionThe C-SII score was more accurate for predicting the clinical outcomes of NSCLC patients with BM who underwent stereotactic radiotherapy. The C-SII score, which was superior to either score alone, could be used to identify BM in NSCLC patients with poor outcomes.
Perineural Invasion Is a Significant Indicator of High Malignant Degree and Poor Prognosis in Esophageal Cancer: A Systematic Review and Meta-Analysis
Authors: Bai Liuyang , Yan Liangying , Guo Yaping , He Luyun , Sun Zhiyan , Cao Wenbo , Lu Jing , Mo Saijun 
Published: June 2022

BackgroundPerineural invasion (PNI) is a malignant metastatic mode of tumors and has been reported in many tumors including esophageal cancer (EC). However, the role of PNI in EC has been reported differently. This systematic review and meta-analysis aims to focus on the role of PNI in EC.MethodsEight databases of CNKI, VIP, Wanfang, Scopus, Wiley, ISI, PubMed, and EBSCO are used for literature search. The association of PNI with gender, pathological stages of T and N (pT and pN), lymphovascular invasion (LVI), lymph node metastasis, 5-year overall survival (OS), and 5-year disease-free survival (DFS) was examined in the meta-analysis by Revman5.0 Software. The pooled OR/HR and 95% CI were used to assess the risk and prognostic value.ResultsSixty-nine published studies were screened for analysis of PNI in EC. The incidence of PNI in esophageal squamous carcinoma (ESCC) and esophageal adenocarcinoma (EAC) was different, but not statistically significant (p &gt; 0.05). The PNI-positive patients had a significantly higher risk of pT stage (OR = 3.85, 95% CI = 2.45–6.05, p &lt; 0.00001), pN stage (OR = 1.86, 95% CI = 1.52–2.28, p &lt; 0.00001), LVI (OR = 2.44, 95% CI = 1.55–3.85, p = 0.0001), and lymph node metastasis (OR = 2.87, 95% CI = 1.56–5.29, p = 0.0007). Furthermore, the cumulative analysis revealed a significant correlation between PNI and poor OS (HR = 1.37, 95% CI = 1.24–1.51, p &lt; 0.0001), as well as poor DFS (HR = 1.55, 95% CI = 1.38–1.74, p &lt; 0.0001).ConclusionPNI occurrence is significantly related to tumor stage, LVI, lymph node metastasis, OS, and DFS. These results indicate that PNI can serve as an indicator of high malignant degree and poor prognosis in EC.