bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Intensity Concentric-Eccentric Exercise Under Hypoxia Changes the Blood Metabolome of Trained Athletes
Authors: Dünnwald Tobias , Paglia Giuseppe , Weiss Günter , Denti Vanna , Faulhaber Martin , Schobersberger Wolfgang , Wackerhage Henning 
Published: June 2022

The aim of this study was to determine alterations of the metabolome in blood plasma in response to concentric-eccentric leg exercise performed at a simulated altitude of 3,500 m. To do so, we recruited 11 well-trained subjects and performed an untargeted metabolomics analysis of plasma samples obtained before, 20 min after as well as on day 8 after five sets of maximal, concentric-eccentric leg exercises that lasted 90 s each. We identified and annotated 115 metabolites through untargeted liquid chromatography-mass spectrometry metabolomics and used them to further calculate 20 sum/ratio of metabolites. A principal component analysis (PCA) revealed differences in-between the overall metabolome at rest and immediately after exercise. Interestingly, some systematic changes of relative metabolite concentrations still persisted on day 8 after exercise. The first two components of the PCA explained 34% of the relative concentrations of all identified metabolites analyzed together. A volcano plot indicates that 35 metabolites and two metabolite ratios were significantly changed directly after exercise, such as metabolites related to carbohydrate and TCA metabolism. Moreover, we observed alterations in the relative concentrations of amino acids (e.g., decreases of valine, leucine and increases in alanine) and purines (e.g., increases in hypoxanthine, xanthine and uric acid). In summary, high intensity concentric-eccentric exercise performed at simulated altitude systematically changed the blood metabolome in trained athletes directly after exercise and some relative metabolite concentrations were still changed on day 8. The importance of that persisting metabolic alterations on exercise performance should be studied further.
Comparison of Retinal Changes Following Silicone Oil and Perfluoropropane Gas Tamponade for Proliferative Diabetic Retinopathy Patients
Authors: Wang Tan , Wang Erqian , Chen Huan , Li Ningning , Min Hanyi 
Published: June 2022

Purpose: To investigate the different tamponade effects of intravitreal silicone oil (SO) and perfluoropropane gas on the retinal structure and vasculature in proliferative diabetic retinopathy (PDR) patients.Methods: Thirty-eight eligible patients (47 eyes) with PDR requiring pars plana vitrectomy (PPV) were enrolled in the prospective observational study. Subjects were divided into two groups after PPV: SO group subjects underwent SO tamponade, whereas Gas group subjects underwent perfluoropropane gas tamponade. The primary outcomes of this study were longitudinal changes in retinal structure and vasculature between 10 and 90 days after the operation. Secondary outcomes were longitudinal changes in peripapillary retinal nerve fiber layer (pRNFL) thickness between 10 and 90 days after the operation in each sector.Results: Thirty-six eyes of 27 patients with a median age of 56.6 ± 9.8 years completed follow-up and were statistically analyzed. No significant difference in demographics or clinical characteristics was found between the two groups. Eyes in the SO group had a statistically significant decrease in pRNFL thickness at 90 days after PPV (p &lt; 0.001), and there was a significant intergroup difference compared with the Gas group (p = 0.001), except for the temporal sector. Eyes in the Gas group had a statistically significant increase in parafoveal vessel density (VD) of the superficial vascular complex (SVC) at 90 days after PPV (p = 0.023), although there was no significant intergroup difference. The type of tamponade, changes in full retina thickness, and parafoveal SVC VD showed a significant correlation with changes in pRNFL thickness (all p &lt; 0.05).Conclusion: SO tamponade resulted in a significantly greater decrease in pRNFL over 90 days than gas tamponade in patients with PDR. In addition, the change in the pRNFL was significantly correlated with changes in full retina thickness and SVC VD after the operation.
Depression, Anxiety, Stress, and Their Associations With Quality of Life in a Nationwide Sample of Psychiatrists in China During the COVID-19 Pandemic
Authors: Li Mengdie , Xia Lei , Yang Yating , Zhang Ling , Zhang Shujing , Liu Tingfang , Liu Yuanli , Kaslow Nadine J. , Jiang Feng , Tang Yi-lang , Liu Huanzhong 
Published: June 2022

ObjectivesThe COVID-19 pandemic has negatively affected wellbeing. However, the impact on the mental health status of Chinese psychiatrists and their relationship with quality of life (QOL) has not been examined.MethodsThis was a national cross-sectional survey performed between January 11 and March 15, 2021. Demographic and work-related data were collected anonymously using an online questionnaire. Common mental health symptoms and QOL were assessed using the Depression Anxiety Stress Scale-Chinese version and the World Health Organization Quality of Life Schedule-Brief, respectively.ResultsA total of 3,783 psychiatrists completed this questionnaire. The prevalence of depressive, anxious, and stress symptoms were 26.7% (95%CI = 25.3–28.1%), 24.1% (95%CI = 22.8–25.5%), and 11.6% (95%CI = 10–12%), respectively. Moreover, 11.1% of the participants endorsed both depressive and anxious symptoms, and 8% endorsed symptoms in all three domains. Binary logistic regression showed that aged 30–39 years (OR = 1.5, P = 0.03), male gender (OR = 1.2, P = 0.04), single (OR = 1.44, P = 0.01), and having a negative perception of the COVID-19 on healthcare (OR = 2.34, P &lt;0.001) were factors associated with higher levels of depressive symptoms. Participants who were divorced and widowed (OR = 1.56, P = 0.03), worked more than 4 night shifts/month (OR = 1.33, P&lt;0.001) and/or longer working years (OR = 1.71, P &lt; 0.001), and had a negative perceived impact of the COVID-19 on healthcare (OR = 2.05, P &lt; 0.001) were more inclined to experience anxious symptoms. In addition, psychiatrists with high QOL scores had lower odds of experiencing depressive, anxious, and stress symptoms (all P &lt; 0.001). Multivariate analysis showed that the presence of each of the three types of mental health symptoms was independently associated with lower QOL (all P &lt; 0.05). In addition, the depression × anxious × stress interaction was significantly correlated with lower QOL (P &lt; 0.05).ConclusionApproximately one-fourth of psychiatrists in China experienced depressive and anxious symptoms during the COVID-19 pandemic, and more than one-tenth reported stress. Mental health symptoms were significant contributors to lower QOL. The psychological wellbeing of psychiatrists during the pandemic requires more attention, and interventions are needed to improve the psychological wellbeing and QOL of physicians who care for individuals with mental disorders.
Associations Between Personality Functioning, Childhood Trauma and Non-adherence in Cardiovascular Disease: A Psychodynamically-Informed Cross-Sectional Study
Authors: Haller Karl , Fritzsche Stefan , Kruse Irina , O’Malley Grace , Ehrenthal Johannes C. , Stamm Thomas 
Published: June 2022

ObjectiveAlthough treatment adherence and lifestyle changes significantly improve the prognosis of cardiovascular disease, many patients do not comply with clinician recommendations. Personality functioning appears to be of importance and is hypothesized to be superior to symptom-based measures in explaining individual differences in non-adherence.Methods194 cardiology inpatients (mean age = 70.6 years, 60% male) were assessed using self-report measures in a cross-sectional design. Patients were assessed using the short version of the Operationalized Psychodynamic Diagnosis Structure Questionnaire (OPD-SQS) to measure personality functioning, as well as the Childhood Trauma Screener (CTS), the Patient Health Questionnaire (PHQ-9) for symptoms of depression, and the Generalized Anxiety Disorder Scale-7 (GAD-7). To assess non-adherence we introduced a brief, novel scale.ResultsNon-adherence correlated significant with personality functioning (r = 0.325), childhood trauma (r = 0.204) and depressiveness (r = 0.225). In a stepwise multiple regression analysis with socio-demographic variables inputted into the model, higher deficits in personality functioning, higher levels of childhood trauma, and male gender were associated with non-adherence (adjusted R2 = 0.149, F(3,190) = 12.225, p &lt; 0.01). Level of depressive symptoms, anxiety, age, education, and income showed no significant additional predictive value and were excluded from the model.ConclusionIn cardiovascular disease, personality functioning, childhood trauma and male gender are associated with non-adherence and appear to be more important than symptom reports of depression and anxiety. This highlights the relevance of basic impairments in intra- and interpersonal functioning in chronic disease, where the patient’s adherence is central.
Second Wave of COVID-19 Pandemic in Argentinian Population: Vaccination Is Associated With a Decrease in Depressive Symptoms
Authors: Benedetti Pedro , Barbuzza Alejo , Moscato Franco , Reppucci Victoria , Goyeneche Celina , Katche Cynthia , Medina Jorge H. , Viola Haydee , Ballarini Fabricio , Moncada Diego 
Published: June 2022

BackgroundSince the irruption of the coronavirus disease 2019 (COVID-19) the planet has submerged in a time of concern and uncertainty, with a direct impact on people's mental health. Moreover, the recurrent outbreaks that periodically harry different regions of the world constantly refocus people's concerns to the pandemic. Yet, each new wave heats the diverse countries in different situations, including the advances in their vaccination campaigns. In this research, we studied the levels of the general anxiety disorder (GAD) and depression in the Argentine population across the first and second waves of infections that occurred in our country.MethodsWe conducted an on-line survey, within each peak of the pandemic. People were asked to self-report GAD and depression symptoms using the GAD-7 and PHQ-9 questioners, inform their vaccination status, the frequency they performed physical activity as well as working condition and modality. Here, we identified the more vulnerable groups and evaluated factors that could mitigate the rise of these mental disorders, focusing on vaccination.ResultsOur data shows that reported GAD and depression levels were higher during the second wave than during the first one. More importantly, vaccinated people were less depressed than non-vaccinated people, while GAD levels remained equivalent in both groups. Other factors directly associated with lower GAD and depression levels were performing frequent physical activity and being employed, regardless of the employment modality. These observations were replicated in different age ranges and genders.ConclusionThis work evidences GAD and depression in different pandemic waves in Argentina, as well the factors that may contribute to reducing the magnitude of these disorders, including vaccination.
Mental Health Survey of Social Entrepreneurs During COVID-19: A Study From Pakistan
Authors: Hussain Nida , Li Baoming 
Published: June 2022

BackgroundCOVID-19 is widely considered one of the worst pandemics in history, resulting in worldwide lockdowns, social isolation, unemployment, and economic recession. With the prolongation of COVID-19, numerous people experience stress, depression, and other mental health challenges. Recently, several studies have been documented in the literature on mental health issues among students (related to medical or other fields), teachers, medical personnel, and nurses in the wake of the COVID-19 pandemic. However, social entrepreneurs (SEs) have received insufficient attention. This study aims to conduct an online survey in Pakistan's five major cities to investigate more about the mental health status of social entrepreneurs.Materials and MethodsAn online survey which included the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) was employed to collect data. The data analyses were carried out employing descriptive statistics, chi-square test, and multiple regression analyses.ResultsA total of 840 social entrepreneurs from Pakistan participated in the survey. Among these, 366 (43.6%) were female and 474 (56.4%) were male. The findings revealed that 709 (84%) social entrepreneurs were suffering from depression symptoms, and 600 (80%) were suffering from anxiety symptoms. The majority of social entrepreneurs with depression (N = 546) and anxiety (N = 567) had mild and moderate stages. In addition, optional open-ended questions were asked from SE participants that help to understand their perception and response to the COVID-19 pandemic.ConclusionThe study concluded that several SEs in major cities of Pakistan were experiencing depression and anxiety symptoms. Based on data analysis, male SEs were highly suffering from depression and anxiety than female SEs. Limited resources and changes in customers' behavior were one of the major problems that lead SEs to depression and anxiety during the COVID-19 epidemic. In addition, SEs revealed that the lack of a social business execution policy is the most distressing factor for them. Therefore, a local government must take rigorous precautionary measures to prevent mental health issues among social entrepreneurs. Moreover, the Government of Pakistan needs to adopt supportive policies to assist social entrepreneurs in stressful circumstances.
Cognitive Impairment and Its Associated Factors in Older Adults Living in High and Low Altitude Areas: A Comparative Study
Authors: Liu Shou , Wang Fei , Zhang Cheng , Zhang Qinge , Dang Zhan-Cui , Ng Chee H. , Xiang Yu-Tao 
Published: June 2022

BackgroundCognitive impairment is a major health concern in older adults. Few studies have examined the association between environmental factors and cognitive impairment, especially in high altitude areas. In this study, the prevalence of cognitive impairment in older adults living in high altitude was compared with those living in low altitude areas.MethodsThis was a comparative study conducted at Qinghai (high altitude group), and Guangzhou (low altitude group), China. Cognition, depressive symptoms and quality of life (QOL) were assessed using the Montreal Cognitive Assessment (MoCA), Patient Health Questionnaire (PHQ-9) and WHO Quality of Life brief version–WHOQOL-BREF, respectively.ResultsAltogether, 644 older adults (207 in Qinghai and 437 in Guangzhou) completed the assessment. The prevalence rate of cognitive impairment was 94.7% (95% CI: 91.6–97.7%) in older adults living in the high altitude area, while the corresponding figure was 89.2% (95% CI: 86.3–92.1%) in the low altitude area. After controlling for covariates, the high altitude group appeared more likely to have cognitive impairment (OR = 2.92, 95% CI: 1.23–6.91, P = 0.015) compared with the low altitude group. Within the high altitude group sample, multinomial logistic regression analysis revealed that older age (aged 74 and above) was significantly associated with higher risk of severe cognitive impairment (OR = 3.58, 95%CI: 1.44–8.93, P = 0.006), while higher education level (secondary school and above) was associated with decreased risk of moderate cognitive impairment (OR = 0.43, 95%CI: 0.22–0.85, P = 0.006). Within the high altitude group, QOL did not differ significantly between normal/mild, moderate and severe cognitive impairment subgroups across physical [F(1, 207) = 1.83, P = 0.163], psychological [F(1, 207) = 1.50, P = 0.225], social [F(1,207) = 2.22, P = 0.111] and environmental domains [F(1,207) = 0.49, P = 0.614].ConclusionThis study found that cognitive impairment was more common among older adults living in the high altitude area. Regular screening and appropriate interventions should be provided to older adults in need.
The Relationship Among BDNF Val66Met Polymorphism, Plasma BDNF Level, and Trait Anxiety in Chinese Patients With Panic Disorder
Authors: Chu Lijun , Sun Xia , Jia Xiaoju , Li Dazhi , Gao Ping , Zhang Yong , Li Jie 
Published: June 2022

BackgroundBrain-derived neurotrophic factor (BDNF) is a candidate for susceptibility locus of Panic disorder (PD). However, the findings about the role of the BDNF Val66Met variant in PD were not consistent. Till now, the relationship between BDNF Val66Met polymorphism and anxiety-related traits in PD patients has been rarely explored. This study aimed to explore the relationship among BDNF Val66Met polymorphism, plasma BDNF level and anxiety-related trait in Chinese PD patients.MethodThis multi-center study included 116 PD patients and 99 health controls. We detected single-nucleotide polymorphism (SNP) of BDNF rs6265 (Val66Met) and BDNF plasma level in the two groups. In addition, PD patients were administered the State-Trait Anxiety Inventory (STAI), Panic Disorder Severity Scale-Chinese Version (PDSS-CV) and Hamilton Anxiety Rating Scale (HAMA-14). Quantitative comparison of the differences of BDNF concentration among subjects with different genotypes and association between BDNF Val66Met genotype and trait anxiety were performed.ResultsThere were no significant differences in the genotype frequency (p = 0.79) or allele frequency (p = 0.88) between PD patients and health controls. BDNF plasma levels of PD patients were significantly lower than those in control group (p = 0.003). BDNF plasma levels of the Met/Met genotype were significantly lower than those of Val/Met genotype in PD patients (p = 0.033). PD patients carried Met/Met genotype showed significantly higher scores in STAI trait compared to those carried Val/Val genotype (p = 0.045) and Val/Met genotype (p = 0.018). STAI trait scores of PD patients with agoraphobia were significantly higher than those of patients without agoraphobia (p &lt; 0.05). The ANCOVA showed that the dependent variable STAI trait score was significantly affected by factor “genotype” (Val/Val, Val/Met, Met/Met, p = 0.029), and covariate “agoraphobia” (p = 0.008). In this model, 11.5% of the variance of the STAI trait score was explained by the BDNF genotype. Contrast analysis showed STAI trait scores of Met/Met subjects were significantly higher than those of Val/Met (p = 0.018) and Val/Val individuals (p = 0.045).ConclusionWe found that anxiety trait was associated with the BDNF polymorphism in PD patients. BDNF Met/Met genotype may decrease plasma BDNF level and increase trait anxiety in panic disorder.
The Implementation Process of Two Evidence-Based Protocols: A Spatial Neglect Network Initiative
Authors: Hreha Kimberly , Barrett A. M. , Gillen Robert W. , Gonzalez-Snyder Chris , Masmela Jenny , Chen Peii 
Published: June 2022

IntroductionSpatial neglect, a neurocognitive disorder of lateralized spatial attention, is prevalent among stroke survivors especially in inpatient rehabilitation facilities (IRFs). The ultimate goal of the project was to improve spatial neglect care in inpatient rehabilitation and trained as many OTs as possible using both tools in their regular practices as the means to achieve our overall objective. Therefore, we conducted a project aimed at implementing two evidence-based protocols, one for assessment (KF-NAP®) and the other for treatment (KF-PAT®), and share the implementation process, which included barriers and facilitators identified during and after the process, and implementation outcomes.MethodsSixteen IRFs were involved. The Knowledge-To-Action Cycle was used to describe the process of knowledge inquiry (training), translating knowledge (implementation) and evaluating the use of knowledge in clinical practice (outcomes). Barriers and strategies were reported using the Consolidated Framework for Implementation Research and identified through a survey, after the study concluded.ResultsThirty-two therapists at the participating sites were trained to some level of the KF-NAP and KF-PAT. Throughout the project and also once after it finished, different barriers were identified by researchers and clinicians, who then determined together actions to eliminate or minimize the barriers. For example, multiple sites reported: “not having time to train other staff at their hospital due to high patient volume and other responsibilities.”DiscussionThe project shared our implementation process which demonstrated the importance of using implementation methods and incorporating a researcher-clinician partnership, not only for knowledge generation but also knowledge translation. Frequent communications and exchanging information with stakeholders at different levels, may be determinant to the success of each implementation phase. Further research is needed.
Doppler ultrasound assessment results at stages of orthodontic treatment
Authors: Dmitrienko I. V. 
Published: June 2022

Relevance. A modern diagnostic complex when planning orthodontic treatment is impossible without assessing the condition of periodontal tissues.Purpose. To evaluate the changes in periodontal tissues during orthodontic treatment.Material and methods. Blood velocity and flow rate in the anterior mandible were compared before and after the orthodontic treatment.Results. Blood velocity and volumetric blood flow rate significantly increased 6 ± 2 months after the beginning of orthodontic treatment.Conclusion. Orthodontic movement of crowded teeth using aligners proceeds without excessive pressure, which allows for a smooth and gradual change in the blood velocity and volumetric blood flow rate, pulsation index and peripheral resistance index.
Experience in the toothpaste’s hygienic effectiveness assessment by oral ﬂuid biochemical parameters
Authors: Gromova S. N. , Elikov A. V. , Ogorodova N. Yu. , Pishkina O. A. , Gromov Ya. P. , Guzhavina N. A. , Koledaeva A. K. 
Published: June 2022

Relevance. The oral hygiene and prevention quality depends on toothpaste. The literature analysis shows the underuse of saliva biochemical parameters for assessing oral hygiene product effectiveness.Materials and methods. Thirty-three subjects aged 19 to 22 years participated in the study. The participants used four kinds of toothpaste by the same manufacturer to evaluate the toothpaste’s effectiveness. We conducted clinical examinations and collected saliva samples on the 1st, 14th and 28th days of the study. The saliva was collected on an empty stomach without stimulation in the morning. Then it was centrifuged. The supernatant was biochemically studied.Results. The study established the criteria for the toothpaste’s low effectiveness, which involve a signifcant increase in hygienic indices and total antioxidant activity, associated with a statistically signifcant trend towards an increase in lactate content. The criteria for a toothpaste with medium effectiveness are a signifcant decrease in one of the hygienic indices, associated with an alkaline pH shift, and an increase in the total antioxidant activity, without signifcant changes in the lactate content. The criteria for a highly effective toothpaste are a signifcant decrease in hygienic indices, and an alkaline pH shift, associated with a signifcant lactate decrease. Determination of total calcium and inorganic phosphorus in the oral ﬂuid may be crucial for assessing the toothpaste remineralizing properties. The glucose content in mixed saliva yields little information for the toothpaste’s hygienic effectiveness assessment.Conclusion. We can recommend saliva biochemical parameters for assessing the oral hygiene status and the effectiveness of oral hygiene products during oral hygiene product comprehensive studies.