bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inflammation-Related LncRNAs Signature for Prognosis and Immune Response Evaluation in Uterine Corpus Endometrial Carcinoma
Authors: Gu Hongmei , Song Jiahang , Chen Yizhang , Wang Yichun , Tan Xiaofang , Zhao Hongyu 
Published: June 2022

BackgroundsUterine corpus endometrial carcinoma (UCEC) is one of the greatest threats on the female reproductive system. The aim of this study is to explore the inflammation-related LncRNA (IRLs) signature predicting the clinical outcomes and response of UCEC patients to immunotherapy and chemotherapy.MethodsConsensus clustering analysis was employed to determine inflammation-related subtype. Cox regression methods were used to unearth potential prognostic IRLs and set up a risk model. The prognostic value of the prognostic model was calculated by the Kaplan-Meier method, receiver operating characteristic (ROC) curves, and univariate and multivariate analyses. Differential abundance of immune cell infiltration, expression levels of immunomodulators, the status of tumor mutation burden (TMB), the response to immune checkpoint inhibitors (ICIs), drug sensitivity, and functional enrichment in different risk groups were also explored. Finally, we used quantitative real-time PCR (qRT-PCR) to confirm the expression patterns of model IRLs in clinical specimens.ResultsAll UCEC cases were divided into two clusters (C1 = 454) and (C2 = 57) which had significant differences in prognosis and immune status. Five hub IRLs were selected to develop an IRL prognostic signature (IRLPS) which had value in forecasting the clinical outcome of UCEC patients. Biological processes related to tumor and immune response were screened. Function enrichment algorithm showed tumor signaling pathways (ERBB signaling, TGF-β signaling, and Wnt signaling) were remarkably activated in high-risk group scores. In addition, the high-risk group had a higher infiltration level of M2 macrophages and lower TMB value, suggesting patients with high risk were prone to a immunosuppressive status. Furthermore, we determined several potential molecular drugs for UCEC.ConclusionWe successfully identified a novel molecular subtype and inflammation-related prognostic model for UCEC. Our constructed risk signature can be employed to assess the survival of UCEC patients and offer a valuable reference for clinical treatment regimens.
Psychological Distress and Access to Mental Health Services Among Undergraduate Students During the COVID-19 Lockdown in Uganda
Authors: Nantaayi Brandy , Ndawula Rodney Kato , Musoke Phillip , Ssewante Nelson , Nakyagaba Lourita , Wamala Joyce Nakiganda , Makai Emmanuel Arthur , Wannyana Babrah , Wamala Nicholas Kisaakye , Kanyike Andrew Marvin , Akech Gabriel Madut , Ojilong Daniel , Agira Drake , Nakimuli Ann Barbra , Asiimwe Asaph , Bongomin Felix 
Published: June 2022

BackgroundLockdown is an important public health approach aimed at curbing the raging effect of the coronavirus disease-2019 (COVID-19). This study aimed at determining the impact of prolonged lockdown on mental health and access to mental health services among undergraduate students in Uganda.MethodsAn online cross-sectional study was conducted anonymously among undergraduates across 10 universities in Uganda. The Distress Questionnaire-5 (DQ-5) and the Patient Health Questionnaire-2 (PHQ-2) were used. Logistic regression analysis was conducted to determine factors associated with psychological distress.ResultsWe enrolled 366 participants with a mean age of 24.5 ± 4.6 years. The prevalence of psychological distress was 40.2% (n = 147) (cut off 14/25 based on DQ-5) while depression stood at 25.7% (n = 94; cut off 3/6 based on PHQ-2) with mean scores of 12.1 ± 4.6 and 1.7 ± 1.6 respectively. Female gender (aOR: 1.6, 95%CI: 1.0–2.6, p = 0.032), pursuing a non-medical program (aOR: 2.2, 95%CI: 1.3–3.7, p = 0.005) were factors associated with psychological distress while non-medical program (aOR: 2.2, 95%CI: 1.3–3.7, p = 0.005) was associated with increased depression. Access to mental health services was associated with both reduced distress (aOR: 0.5, 95%CI: 0.3–0.8, p = 0.005) and depression (aOR: 0.6, 95%CI: 0.3–0.9, p = 0.034). A majority (65.3%) of the participants reported knowing how to access mental health care and 188 (51.4%) reported having needed emotional support but, only 67 (18.3%) ever sought care from a mental health professional. Of those who had access, only 10 (7%), and 13 (9%) accessed a counselor or a mental health unit, respectively. The barriers to accessibility of mental health care included financial limitations (49.5%), lack of awareness (32.5%), lack of mental health professionals (28.4%), and stigma (13.9%).ConclusionAmong university students in Uganda during the COVID- 19 lockdown, the burden of psychological distress and depression was substantial. However, access to mental health services was limited by several factors.
The Impact of the COVID-19 Pandemic on the Mental Health of Healthcare Workers in Italy: Analyzing the Role of Individual and Workplace-Level Factors in the Reopening Phase After Lockdown
Authors: Moro Maria Francesca , Calamandrei Gemma , Poli Ranieri , Di Mattei Valentina , Perra Alessandra , Kurotschka Peter Konstantin , Restrepo Alexandra , Romano Ferdinando , La Torre Giuseppe , Preti Emanuele , Mascayano Franco , Picardi Angelo , Chiarotti Flavia , Rapisarda Venerando , Urban Antonio , Alvarado Ruben , Susser Ezra , Carta Mauro Giovanni 
Published: June 2022

IntroductionItaly is one of the high-income countries hit hardest by Covid-19. During the first months of the pandemic, Italian healthcare workers were praised by media and the public for their efforts to face the emergency, although with limited knowledge and resources. However, healthcare workers soon had to face new challenges at a time when the national health system was working hard to recover. This study focuses on this difficult period to assess the impact of the COVID-19 pandemic on the mental health of Italian healthcare workers.Materials and MethodsHealthcare workers from all Italian regions [n = 5,502] completed an online questionnaire during the reopening phase after the first wave lockdown. We assessed a set of individual-level factors (e.g., stigma and violence against HCWs) and a set of workplace-level factors (e.g., trust in the workplace capacity to handle COVID-19) that were especially relevant in this context. The primary outcomes assessed were score ≥15 on the Patient Health Questionnaire-9 and score ≥4 on the General Health Questionnaire-12, indicators of clinically significant depressive symptoms and psychological distress, respectively. Logistic regression analyses were performed on depressive symptoms and psychological distress for each individual- and workplace-level factor adjusting for gender, age, and profession.ResultsClinically significant depressive symptoms were observed in 7.5% and psychological distress in 37.9% of HCWs. 30.5% of healthcare workers reported having felt stigmatized or discriminated, while 5.7% reported having experienced violence. Feeling stigmatized or discriminated and experiencing violence due to being a healthcare worker were strongly associated with clinically significant depressive symptoms [OR 2.98, 95%CI 2.36–3.77 and OR 4.72 95%CI 3.41–6.54] and psychological distress [OR 2.30, 95%CI 2.01–2.64 and OR 2.85 95%CI 2.16–3.75]. Numerous workplace-level factors, e.g., trust in the workplace capacity to handle COVID-19 [OR 2.43, 95%CI 1.92–3.07] and close contact with a co-worker who died of COVID-19 [OR 2.05, 95%CI 1.56–2.70] were also associated with clinically significant depressive symptoms. Similar results were found for psychological distress.ConclusionsOur study emphasizes the need to address discrimination and violence against healthcare professionals and improve healthcare work environments to strengthen the national health system's capacity to manage future emergencies.
Influencing Factors Related to Female Sports Participation Under the Implementation of Chinese Government Interventions: An Analysis Based on the China Family Panel Studies
Authors: Fang Ping , Sun Lei , Shi Shu Sheng , Ahmed Laar Rizwan , Lu Yan 
Published: June 2022

ObjectivesRegular sports participation is a gendered phenomenon in China. Women have reported much higher constraints than men on time, partner, psychology, knowledge, and interest. This study explores personal, family, lifestyle, and health factors associated with sports participation.Study DesignThis study is a cross-sectional study.MethodsData were collected from the national reprehensive China Family Panel Studies (CFPS) database (2018) to analyze personal information, family background, lifestyle, and health in relation to women's sports participation. Multiple classification logistic regression was used to quantify the association between independent variables and sports time.ResultsWomen with high personal income and education, who were unmarried, in faster economic development areas have more awareness and more time for sports participation. Women who were overweight and self-rated as unattractive spent less time on sports participation. Women with a small family population and no children have more time for sports participation. Less time on the internet and moderate sleep contribute to active sports participation. Women with chronic diseases and high medical costs are less likely to participate in sports.ConclusionsNegative body aesthetic perception, the burden of family environment, modernization of lifestyle, and the normalization of sub-health are essential factors affecting women's sports participation. The government should understand the inner and outer barriers to women's participation in sports, develop policies and regulations to protect and support women's sports participation, and guide and monitor the effective implementation of women's sports activities.
Post-Transplantation Cytomegalovirus Infection Interplays With the Development of Anastomotic Biliary Strictures After Liver Transplantation
Authors: Georges Pauline , Clerc Clémentine , Turco Célia , Di Martino Vincent , Paquette Brice , Minello Anne , Calame Paul , Magnin Joséphine , Vuitton Lucine , Weil-Verhoeven Delphine , Lakkis Zaher , Vanlemmens Claire , Latournerie Marianne , Heyd Bruno , Doussot Alexandre 
Published: June 2022

Background: Anastomotic biliary stricture (ABS) remains the most frequent complication after liver transplantation (LT). This study aimed to identify new anastomotic biliary stricture risk factors, with a specific focus on postoperative events. Additionally, ABS management and impact on patient and graft survival were assessed.Methods: All consecutive patients who underwent LT with duct-to-duct anastomosis between 2010 and 2019 were included. All patients who died within 90 days after LT due to non-ABS-related causes were excluded.Results: Among 240 patients, 65 (27.1%) developed ABS after a median time of 142 days (range, 13–1265). Median follow-up was 49 months (7–126). Upon multivariable analysis, donor BMI (OR=0.509, p = 0.037), post-LT CMV primoinfection (OR = 5.244, p &lt; 0.001) or reactivation (OR = 2.421, p = 0.015) and the occurrence of post-LT anastomotic biliary fistula (OR = 2.691, p = 0.021) were associated with ABS. Anastomotic technical difficulty did not independently impact the risk of ABS (OR = 1.923, p = 0.051). First-line ABS treatment was systematically endoscopic (100%), and required a median of 2 (range, 1–11) procedures per patient. Repeat LT was not required in patients developing ABS. The occurrence of ABS was not associated with overall patient survival (p = 0.912) nor graft survival (p = 0.521).Conclusion: The risk of developing ABS after LT seems driven by the occurrence of postoperative events such as CMV infection and anastomotic fistula. In this regard, the role of CMV prophylaxis warrants further investigations.
On r-Ideals and m-k-Ideals in BN-Algebras
Authors: Gemawati Sri , Musraini Musnis , Hadi Abdul , Zakaria La , Fitria Elsi 
Published: June 2022

A BN-algebra is a non-empty set X with a binary operation “∗” and a constant 0 that satisfies the following axioms: (B1) x∗x=0, (B2) x∗0=x, and (BN) (x∗y)∗z=(0∗z)∗(y∗x) for all x, y, z ∈X. A non-empty subset I of X is called an ideal in BN-algebra X if it satisfies 0∈X and if y∈I and x∗y∈I, then x∈I for all x,y∈X. In this paper, we define several new ideal types in BN-algebras, namely, r-ideal, k-ideal, and m-k-ideal. Furthermore, some of their properties are constructed. Then, the relationships between ideals in BN-algebra with r-ideal, k-ideal, and m-k-ideal properties are investigated. Finally, the concept of r-ideal homomorphisms is discussed in BN-algebra.
Alterações ecocardiográficas em casos de síndrome de down acompanhados em um serviço genética no Nordeste brasileiro / Echocardiographic alterations in cases of down syndrome followed up in a genetic service in northeastern Brazil
Authors: Filho Francisco André Gomes Bastos , Napoleão Raffaela Neves Mont’alverne , Vasconcelos Gabriel de Albuquerque , Campos Henrique Gonçalves , Ribeiro Erlane Marques 
Published: June 2022

A Síndrome de Down é uma das doença genéticas mais prevalentes no Brasil com cerca de 300 mil afetados e com incidência estimada em 1/600 nascidos vivos. Ela é caracterizada pela trissomia do cromossomo 21, sendo que 95% dos casos ocorrem por trissomia simples, 3% por translocação e 2% por mosaicismo. Embora existam inúmeras malformações em um paciente com trissomia do 21, a cardiopatia congênita está presente em aproximadamente 50% dos afetados e é um dos principais fatores de prognóstico quanto à sobrevida dos pacientes, sendo umas das principais causas de morbidade e mortalidade nos primeiros 2 anos de vida. Objetivamos com este trabalho identificar as principais cardiopatias congênitas na Síndrome de Down em um hospital pediátrico, público, de referência para doenças genéticas no nordeste do Brasil. O estudo é do tipo quantitativo, seccional, transversal e descritivo a partir de revisão de prontuários médicos dos afetados com Síndrome de Down atendidos período de 2002 a 2019 em um Ambulatório de Genética Médica de um hospital pediátrico público. Para análise dos dados foi utilizado o Software Microsoft Excel.Resultados: Foram consultados 307 pacientes (181 M;125 F;1 I) com a primeira consulta realizada com a idade em média 18 meses (0,0–225 meses),foram realizados ECO em 210, sendo 160 com alterações (93M;67F). O achado cardiológico mais prevalente foi o forame oval patente 74 (45%) (51M;23F), comunicação interatrial 52(32%) (23M;29F) e persistência do canal arterioso 39 (24%), (19M;20F) comunicação interventricular 35(21%)(19M;16F), defeito do septo atrioventricular 15(8%)(9M;6F) e 56(31M;25F) pacientes tiveram mais de 1 alteração. Dessa forma A prevalência de alterações ecocardiográficas nos casos de SD foi 76%. O maior número de casos ocorreu no sexo masculino. As cardiopatias congênitas mais comuns foram FOP, CIA, PCA, CIV e DSAV respectivamente.
Desempenho visual e motor de lactentes acompanhados em um programa de seguimento de risco / Visual and motor performance of infants accompanied in a risk follow-up program
Authors: Campos Mara Marusia Martins Sampaio , Souza Rebeca Alves de , Chaves Kellen Yamille dos Santos , Araújo Karla Pimentel de , Batista Adelina Braga , Freitas Carina Santana de , Potrichi Inês Cristina Pereira , Aguiar Lila Maria Mendonça 
Published: June 2022

A prematuridade é reconhecida como um dos maiores determinantes de morbimortalidade neonatal global, de forma que o lactente prematuro necessita ser acompanhado após a alta hospitalar por uma unidade de seguimento ambulatorial de risco, a fim de prevenir ou tratar qualquer alteração em seu desenvolvimento neuropsicomotor. Avaliar o desempenho visual e motor de lactentes acompanhados em um programa de Follow up/seguimento de risco. Este estudo tratou-se de uma série de casos, realizada com 10 lactentes selecionados no ambulatório de Follow up/seguimento de risco da Maternidade Escola Assis Chateaubriand (MEAC), no período de janeiro de 2019 à janeiro de 2020. Os instrumentos utilizados foram: avaliação do desempenho visual e motor por meio do Roteiro de Avaliação da Conduta Visual em Lactentes e a Escala Motora Infantil de Alberta. Na avaliação de desempenho visual, uma criança, no primeiro mês de vida, não pontuou apenas na prova de seguimento visual vertical. Todas apresentaram um desempenho motor normal. No segundo mês, o estudo condiz com o que é esperado para seu desenvolvimento visual normal. Uma não pontuou em três testes em razão de apresentar um pouco mais de uma semana de diferença do grupo do primeiro para o segundo mês. Uma criança não apresentou uma boa pontuação em seu desempenho visual, sendo isso informado a equipe da unidade de atendimento. A maioria apresentou desempenho motor normal; apenas uma com desempenho suspeito, o que é bastante esperado do prematuro. Presume-se que os bons níveis de desenvolvimento, se devam aos estímulos oriundos do programa e aos cuidados neuroprotetores durante a internação hospitalar. No entanto, necessita-se de estudos com amostra mais volumosa a fim de apresentar fielmente a relevância aqui encontrada.
Gamma Spectrometry results for the 134Cs nuclear parameters / Resultados de espectrometria gama para os parâmetros nucleares 134Cs
Authors: Almeida Maria Candida Moreira de , Delgado José Ubiratan , Silva Ronaldo Lins e , Poledna Roberto 
Published: June 2022

134Cs is produced directly as a fission product (low yield) and too obtained by neutron capture from 133Cs non-radioactive . The National Laboratory for Ionizing Radiation Metrology (LNMRI/IRD/CNEN) of Rio de Janeiro performed standardization of this radionuclide . A solution of 134Cs radionuclide was purchased from commercial supplier to nuclear parameters determination such as activity and emission probabilities of some of its energies. 134Cs is a beta gamma emitter with 754 days of half-life. This radionuclide is used as standard in environmental, water and food control. It is also important to germanium detector calibration The gamma emission probabilities were determined mainly for some energies of the 134Cs by efficiency curve method and the mostly uncertainties obtained were around 1.5 %.
A importância da amamentação na primeira hora de vida: análise da literatura atual / The importance of breastfeeding in the first hour of life: analysis of current literature
Authors: Silva Janinne Rosaline Pereira da , Judeikis Guilherme Alexandre , Araújo Renata Corrêa Bezerra de , Oliveira Bruna Soares , Costa Erlânia Souza , Carvalho Luciane de Fátima Fernandes de , Sousa Kallyany Santos , Costa Sarah Aline Alencar 
Published: June 2022

Este estudo tem por objetivo geral: analisar as publicações científicas referentes a importância da amamentação na primeira hora de vida. E como objetivos específicos: caracterizar as publicações científicas encontradas na literatura atual sobre a importância da amamentação na primeira hora de vida; descrever a importância da amamentação na primeira hora de vida e os seus efeitos benéficos para o binômio. Esta pesquisa é da modalidade revisão integrativa, de caráter descritivo, com abordagem qualitativa. Foram selecionadas as bases de dados da SCIELO e da LILACS e destas, utilizando os descritores “Amamentação” AND “Mãe” AND “Recém-nascido”, foram encontrados diversos artigos, que. mediante aplicação dos critérios de inclusão e exclusão da pesquisa, incluíram-se 6 publicações. Os resultados mostram predomínio de publicações no ano de 2016. Todas as publicações apresentaram pontos importantes sobre a amamentação na primeira hora de vida, destacando-se aspectos imprescindíveis, tais como: interação precoce entre o binômio; diminuição do estresse neonatal e estabilização da respiração do bebê; fortalecimento de vínculo entre o binômio e redução da mortalidade neonatal. Porém, houve publicações que mostraram os déficits nos serviços de saúde, expondo a falta de interesse profissional na realização da amamentação na primeira hora de vida, e também dos hospitais de aderirem a esse cuidado. Conclui-se que, existem benefícios para o binômio no que discerne a amamentação na primeira hora de vida; e que é preciso incentivar os profissionais e instituições de saúde sobre a importância da amamentação neste contexto.
Como evoluíram os níveis de estresse e ansiedade em docentes e discentes universitários durante a pandemia da COVID-19?- um estudo transversal repetido / How did stress and anxiety levels evolve in university professors and students during the COVID-19 pandemic? - a repeated cross-sectional study
Authors: Raposo Maria Cristina Falcão , Cordeiro Gauss Moutinho , Farias Morgana Larissa da Silva 
Published: June 2022

O objetivo deste artigo é estudar de forma comparativa a evolução dos níveis de estresse e ansiedade em estudantes e professores universitários durante a pandemia da COVID-19. O método utilizado foi de um estudo transversal repetido três vezes, após o término de cada semestre letivo, com uma amostra de docentes e discentes dos cursos de bacharelado da área de exatas da UFPE. Os instrumentos utilizados foram: um formulário de coleta de dados sociodemográficos, econômicos e de opinião sobre o ensino remoto. A saúde mental foi avaliada pela Escala de Ansiedade, Estresse e Depressão-21 (DASS-21). Os resultados mostram que a prevalência dos sintomas de estresse são maiores que os de ansiedade tanto em docentes quanto em discentes, ao longo do período analisado. Os mesmos sugerem ainda um impacto psicológico negativo da pandemia maior nos estudantes que nos professores.
Reflexión teórica-práctica institucional: mujer y prisión / Reflexão teórico-prática institucional: mulheres e prisão
Authors: Cedeño Carlos Andrés Holguín , Toledo Mónica Maribel Castillo , Caicedo Amalia Paula Angulo , Enríquez Mariuxi de Los Ángeles Rodríguez 
Published: June 2022

Este artículo analiza la situación del Centro de Rehabilitación Social Femenino de la provincia de Esmeraldas-Ecuador, personas privadas de libertad, presas de mentalidad bajo un régimen institucionalizado donde se pone de manifiesto el contexto de la interna tras a ver vivido muchos años en un centro penitenciario, reflexiones hacia una verdadera práctica de intervención destinada a mejorar la situación de salud y social de estas mujeres que por las pocas oportunidades que le brinda la sociedad tienden a delinquir para sobrevivir y satisfacer sus necesidades y las de su familia, siendo procesadas por el delito cometido; la propuesta es leer y analizar las precarias condiciones de vida especialmente en las salud y que tras las rejas nos permitirán conocer la realidad de estos centros en donde la “deshumanización” podrá contraponerse con el verdadero sentido de la rehabilitación pudiendo resultando una agonía para soportar horas muertas en prisión, además de que las féminas por su condición debe ser tratadas y tener una adecuada rehabilitación integral desde la perspectiva de género, la presente investigación determinó que al comprobar la hipótesis la intervención de la estudiantes no es de mucha ayuda ya que al estar institucionalizadas no se permite que se realice un trabajo verdaderamente social para mejorar las horas muertas en prisión, solo se permite que el trabajo se lo realice “fuera” pero en este sentido no hay que hacer ya que la mayor población carcelaria es colombiana sumariadas por tráfico de estupefacientes, se utilizó como instrumento una encuesta .