bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short- and long-term outcomes of laparoscopic resections for intrahepatic cholangiocellular carcinoma
Authors: Efanov M. G. , Alikhanov R. B. , Kazakov I. V. , Britskaia N. N. , Kulezneva Y. V. , Melekhina O. V. , Vankovich A. N. , Koroleva A. A. , Kulikova N. D. , Zamanov E. N. , Tsvirkun V. V. , Khatkov I. E. 
Published: September 2022

Aim. To evaluate short- and long-term results of laparoscopic and open surgeries for intrahepatic cholangiocellular carcinoma.Materials and Methods. The paper presents the retrospectively studied results of laparoscopic and open liver resections in 53 patients (2015–2020). The selection of patients for laparoscopic surgery consisted in maintaining the possibility of performing an R0 resection. A comparison was made before and after the alignment of the groups in relation to the complexity of resection due to the exclusion of resections and the reconstructions of vessels and bile ducts.Results. 53 patients were operated on; 19 patients underwent laparoscopic resection. In the open group, resection and reconstruction of vessels and bile ducts were performed significantly more often. A significantly lower incidence of severe complications and bile leakage was noted in the laparoscopic group, which did not affect the duration of hospital stay. After eliminating the differences in resection complexity, the comparison showed lower blood loss and biliary complications as well as a higher R0 resection rate in the laparoscopic group. The overall and recurrence-free four-year survival did not differ in the groups before and after aligning in terms of resection complexity.Conclusion. The first experience of using laparoscopic access for intrahepatic cholangiocellular carcinoma indicates that it is possible to improve the immediate results of treatment without worsening short- and long-term oncological outcomes.
Hepatocellular cancer. Current trends and the results in surgical treatment
Authors: Shabunin A. V. , Bedin V. V. , Grekov D. N. , Tavobilov M. M. , Drozdov P. A. , Lebedev S. S. , Karpov A. A. , Chechenin G. M. , Tsurkan V. A. 
Published: September 2022

Aim. To analyze the results of a multidisciplinary approach to the treatment of patients with hepatocellular cancer in a multidisciplinary oncology clinic.Materials and Methods. From 2007 to 2021, 259 patients with hepatocellular cancer were surgically treated in the Department of Liver and Pancreas Surgery of the city clinical hospital named after S.P. Botkin. Liver resections of different extent were performed in 74 (28.6%) patients, radiofrequency ablation – in 19 (7.3%), microwave ablation – in 20 (7.7%), hepatic artery chemoembolization with radiofrequency ablation – in 34 (13.1%), regional chemotherapy – in 104 (40.2%), liver transplantation – in 8 (3.1%) patients.Results. The overall five- and ten-year survival after liver resection was 51.4% and 31.1% respectively. The poor prognostic factors following liver resection were age >70 years (p = 0.03), postoperative complications (p = 0.04), lymph node metastases (p = 0.01), and a body mass index >30 kg/m2 (p = 0.045). Complications that developed after radiofrequency (microwave) ablation and chemoembolization of the hepatic artery with radiofrequency ablation were 5.1% and 5.8%. Within 90 days after liver resection, three (1.1%) patients died. Complications after resection developed in 18 (24.3%) cases during the same period. With metastases measuring ≤3 cm, the overall five-year survival after radiofrequency and microwave ablation was 36.8% and 35% respectively. With neoplasms measuring 3–5 cm, the best five-year survival was after hepatic artery chemoembolization and radiofrequency ablation (44.1%). The overall fiveyear survival after hepatic artery chemoembolization was 11.5%. No complications or deaths resulted from liver transplantation. With an average follow-up period of 12.5 months, none of the patients experienced disease recurrence or died.Conclusion. Using a multidisciplinary approach in a multidisciplinary oncology clinic improves the results of treating patients with hepatocellular cancer.
Islet isolation from the pancreas after pancreatectomy. Indications, methodology, evaluation of results
Authors: Zagainov V. E. , Kuchin D. M. , Ermakova P. S. , Vasilchikova E. A. , Lugovaia L. A. , Naraliev N. U. , Kashina A. V. 
Published: September 2022

Aim. To develop and implement a method for isolating the islets of Langerhans from pancreatic tissue after pancreatectomy with islet autotransplantation.Materials and Methods. The study used ten Wiesenau miniature pig pancreases, 30 Wistar rat pancreases, eight resected human pancreases, and five human pancreases from extensive resection or pancreatectomy.Results. Islets of Langerhans completely devoid of human and experimental animals’ acinar tissue were obtained. When using the protocol for mechanical isolation, the efficiency of isolating the islets of Langerhans in humans and experimental animals was 50%. The research proved that the isolated cells belonged to the islets of Langerhans. Additionally, their purity was confirmed. The survival of the isolated islets exceeded 90%. The enzyme immunoassay for insulin synthesis showed that the isolated islets of Langerhans remained functionally active. The sterility of the isolated islet cells was confirmed.Conclusion. This proven isolation technology makes it possible to obtain pure, sterile, viable, and functionally active islet cells suitable for further autotransplantation.
Distal resection for pancreatic tumors
Authors: Kriger A. G. , Gorin D. S. , Pavlov A. V. , Pronin N. A. , Sidorov D. V. , Kaldarov A. R. , Ponezhev K. E. , Panteleev V. I. 
Published: September 2022

Aim. To study the specific features of the splenic artery architectonics and evaluate the results of distal pancreatic resection for various tumors.Materials and Methods. In the anatomical part, we examined 88 organ complexes taken from people whose death was not associated with diseases of the abdominal organs. We studied the topography of the splenic artery and the dependence of the number of its branches to the pancreas on the vessel tortuosity. The clinical part of the study presents the results of 122 distal resections performed during 2016-2021. 79 operations were carried out using the traditional method, 32 operations were robot-assisted, and 11 were performed laparoscopically.Results. The research found a relationship between the degree of the splenic artery tortuosity and the number of branches to the pancreas, which varies from three to nine. Out of the 122 operated patients, in 24 (19.7%) cases a clinically relevant (type B) pancreatic fistula that required additional treatment was formed. Intra-abdominal bleeding developed in 15 (12.3%) patients: early – in 10, late arrosive hemorrhage associated with a pancreatic fistula – in 5 cases. One (0.8%) patient died.Conclusion. It is necessary to consider the architectonics of the splenic artery during distal pancreatic resection. The frequency of pancreatic fistula formation does not depend on the method of performing the operation. Of the prognostic factors, the body mass index is statistically significant. Late arrosive bleeding develops against the background of a clinically relevant pancreatic fistula.
Prediction of severe postoperative complications in pancreatic surgery using the Preoperative Pancreatic Resection (PREPARE) score: a single-center observational study
Authors: Burlov N. N. , Khrykov G. N. , Burlova E. A. , Shostka K. G. 
Published: September 2022

Aim. To evaluate the effectiveness of the PREPARE score in predicting severe complications after pancreatic surgery.Materials and Methods. The case-control study included patients operated on the pancreas. Grade ≥III Clavien– Dindo complications were designated as “severe”. Patients were divided into two groups: “0–II degree” (control) and “III–V degree” (case). For all patients, scores were calculated, and risk categories were determined according to the PREPARE score.Results. The study included 151 patients: “0–II degree” – 102 (68%) observations, “III–V degree” – 49 (32%). ROC analysis was used for the scores (AUC = 0.616; 95% CI 0.527–0.706; p = 0.014) and for the risk categories (AUC = 0.555; 95% CI 0.463–0.648; p = 0.241) of the PREPARE score.Conclusion. The obtained data do not currently enable us to recommend the PREPARE score for predicting complications of pancreatic surgery.
Transfistula cholangioscopy: clarification of the diagnosis and antegrade removal of residual bile duct stones
Authors: Kovalevskii A. D. , Prudkov M. I. 
Published: September 2022

Aim. To demonstrate our own experience of performing transfistula cholangioscopy and removing bile duct stones.Materials and Methods. From 2017 to 2019, 230 patients with functioning external biliary drains underwent antegrade transfistula cholangioscopy. Preliminary dilatation and straightening of the fistulous tract were required in 37 patients.Results. Bile duct stones were detected in 158 (68.7%) patients. During transfistula cholangioscopy, stones were removed from all patients. In 68 cases with large choledocholithiasis, it was necessary to perform contact lithotripsy. To this end, staged treatment and two hospitalizations were required in five cases. Adequate transfistular access to the bile ducts was formed during the first hospital stay; during the second, after hardening of the access walls, the stones were removed. The overall complication rate was 3.8%, including grade III–IV complications (1.9%) according to the Clavien–Dindo classification. Mortality was 0.4%.Conclusion. Transfistula cholangioscopy increases the reliability of stone detection in the bile ducts, permits removing them without mandatory dissection of the major duodenal papilla, and creates favorable conditions for a more accurate assessment of its functional state. When patients with functioning biliary drains and unresolved bile duct diseases are placed in a specialized medical center, they can be provided with high-quality care. Additionally, it creates rational conditions for the use of the highly effective methods of endobiliary diagnosis and treatment.
Prevention of sarcopenia in patients with obesity after bariatric and metabolic surgery: the effect of programmed training on the muscle tissue and anthropometric functions – a randomized controlled trial (SarxOb study protocol)
Authors: Bužga Marek , Pekar Matej , Uchytil Jaroslav , Horká Veronika , Malůš Jan , Vilímek Dominik , Švagera Zdeněk , Kutáč Petr , Holéczy Pavol 
Published: September 2022

Obesity is a serious metabolic disease that significantly increases cardiovascular risks and other health complications. Sarcopenia is an independent risk factor for morbidity and mortality in patients suffering from obesity that increases the health risks and is associated with cardiac, respiratory and other diseases. Bariatric and metabolic surgery (BMS) leads to significant changes in body composition. Our pilot study showed that bariatric patients are at risk of sarcopenia after BMS. This finding resulted in a hypothesis that an exercise plan in the experimental group will lead to postural stabilization and a lower decline in muscle homotopy, further leading to a greater reduction in fat mass and a positive effect of exercise on skeletal muscle volume and strength and endocrine-metabolic function. The aim of the present study is to determine the effect of programmed aerobic and strength training on muscle function, volume, and morphology in patients after BMS. The study is a single-center, randomized clinical trial after sleeve gastrectomy focused on muscle tissue. The experimental group will perform targeted physical activity once a week for 12 months and the training plan will include anaerobic and aerobic components. Magnetic resonance imaging of skeletal muscles will be correlated with the values of densitometry examination and changes in body composition, certain blood parameters of myokines, biomechanical analysis of movement abnormalities, and behavioral and dietary counseling. This study will address the research questions about the effect of programmed training on muscle tissue and muscular functions after BMS.
Mineralogical and gemological characteristics of Kaman (Kırşehir-Türkiye) fluorites
Authors: KAYDU AKBUDAK İlkay , KETENCİ Doğanay Elif , GÜRBÜZ Meltem 
Published: September 2022

Fluorites are found in the region between Hamit, Karakütük, Bayındır and Yeniyapan villages of the Kaman District (Kırşehir-Türkiye). Fluorites are located in altered levels due to faults in quartz syenites containing gray-pink colored K-feldspar, plagioclase and quartz, amphibole and biotite type mafic minerals in the Upper Cretaceous aged. Central Anatolian Granitoids, Fluorites observed in purple and green in places, pink, yellow, white colors as veins reaching from a few centimeters to two meters, purple and green in places, pink, yellow, white colors.
According to X-Ray diffraction (XRD) analysis results, quartz syenites are composed of quartz, feldspar and clay minerals; fluorites are composed of fluorite and quartz mineral combination. According to Wavelength Dispersive XRF (WDXRF) analysis results, it is observed that the amount of F in purple fluorites is 39.8%, the amount of CaO is 51.2%, the amount of SiO2 is 8.68%, the amount of F in green fluorites is 46.7%, the amount of CaO is 51.5%, and the amount of SiO2 is 1.15%. As a result of cathodoluminescence analysis, the presence of rare earth elements (REE) terbium (Tb), erbium (Er), dysprosium (Dy) and samarium (Sm) elements were observed in fluorites.
In order for the fluorites in the region to be used as a gemstone; while features color variety, texture, and easy workability are revealed as positive features, features such as low hardness, low strength in atmospheric conditions, and cleaved structure in coarse crystals are determined as negative features. For this reason, the fluorites in the region can be used as gemstones, however it is important that they undergo improvement methods (saturation with epoxy).
Investigation of pozzolanic properties of acidic and basic tuffs: A case study from Elazığ and Gümüşhane regions
Authors: ASLAN Yasemin , GÜROCAK Zülfü 
Published: September 2022

Pozzolans are used as additives in stabilizing clayey soils and as trass in cement production. Natural and unnatural pozzolans added to the ground in the stabilization process increase the bearing strength and strength of the soil, reduce the deformations that will occur as a result of stresses, settlements, swelling potential, liquefaction potential and permeability. It Pozzolans, which are used in cement and called trass, reduce the heat of hydration, increase the resistance of concrete against cracking, increase the waterproofing of the concrete and prevent the expansion caused by the alkali-aggregate reaction. For this reason, researching materials with natural pozzolanic properties and examining their pozzolanic properties are important for the country's economy.
In this study, chemical and mineralogical studies were carried out to determine the pozzolanic properties of acidic and basic tuffs, and pozzolanic activity tests were carried out on the tuffs. As a result of the studies, although the acidic character tuffs belonging to the Kızılkaya Formation meet the conditions for use as an additive in the stabilization and cement production recommended in the standards, they cannot provide sufficient compressive strength in the pozzolanic activity test. This is due to the low CaO ratio. For this reason, it is necessary to increase the CaO ratio with lime additives in the use of acidic tuffs. It has been concluded that the chemical properties of the basic character tuffs of the Karabakır Formation are not in accordance with the limit values given in the standards, they will not create sufficient pozzolanic reaction and cannot be used as an additive material.
Effect of Health Education through Community leaders on increased knowledge of Households Regarding malaria control, treatment and prevention in intervention and control villages of New Halfa Locality-Kassala State (2017-2020)
Authors: Abdelseed Fazaa Abdallah , Alhadi Magda , Abdalmajed M.A , Mohammed Bakri Yousif 
Published: September 2022

Malaria vector control in Sudan has a long history. The primary vector control interventions are IRS in targeted areas with irrigation schemes, use of LLINs, LSM, and space spraying during an emergency. The present study aimed to assess the effect of Health Education through Community leaders on increased knowledge of Households Regarding malaria control, treatment and prevention in intervention and control villages of New Halfa Locality-Kassala State (2017-2020). Randomized community trials (Controlled intervention study) in New Halfa locality among two communities were randomly assigned to the intervention group which receive health education messages regarding the use of LLINs and control group where there is no health education. A standard Questionnaire was used to collect data from the head of household at each village. The information collected should include the owner and using LLINs, distributed to household. The observation the conditions of LLINs. This Questionnaire was done with committee for integrated vector management - Federal Ministry of Health and WHO. There were association between education level and overall mean knowledge of respondents about mosquito breeding sites, malaria control, uncomplicated malaria symptoms, severe malaria symptoms, and uncomplicated malaria treatment, severe malaria treatment, and fever treatment, p < 0.05. However, the overall mean knowledge was significantly more significant among those who have University education were compared to other level of education, p< 0.05. An increase knowledge scores was observed when pre- and post-test scores on malaria prevention and control were compared. Health education packages.i.e., mass media messages during Bed nets campaigns and the role of community leaders on malaria, was found to have improved knowledge of malaria prevention and control among the studied community.
Assessment of Primary Healthcare Facilities Coverage in Rural Population of Sharg-Elnil Locality - Khartoum State from 2018 to 2020.
Authors: Abdalla H.A. , Abdalla M.A. , Abdalmajed M.A. 
Published: September 2022

Background: Sudan’s health system is based on the district health system approach, which emphasizes the principles of Primary HealthCare (PHC). Nevertheless, the decentralization of the public sector resulted in more deterioration of the PHC system particularly in rural and peripheral areas due to lack of financial resources and managerial capacities.
Objectives: The study aimed to assess the primary Healthcare facilities coverage for rural population in Sharg Elnil locality from 2018 to 2020. The study was conducted in the rural areas of Sharg Elnil locality.
Materials and methods: Analytical, prospective Facility based study. A number of (37) Health facility was selected for the study. The study was conducted by using questionnaires. Data was computed and analyzed using SPSS program version 25.0. Descriptive and inferential statistic was used.
Results: The majority of health facilities were compliance with classification of ministry of health standards (94.6%). The number of villages that health facility covered in rural hospital was (10.3±1.4), (4.9±.5) health centers and (3.9±.6) in dispensaries. The vast majority of health facilities 83.8% have a mean of transportation to access health facility. Nearly half of the health facilities were distance less than 2 km of health area 48.6%. The vast majority of health facilities 83.8% have a mean of transportation to access health facility. The majority of health services available in health facilities were vaccination service (100%), nutrition services (94.6%), reproductive health services (70.3%), health education services (64.9% ), disease surveillance system (64.9%), Essential, Community mobilization service (51.4%) while the health services available by less than 50% were drugs list in the health facility (45.9%), Health insurance coverage (27%) Free drugs for children less than 5 yrs (16.2%), the lab services (21.6%), referred system 24.3%, ambulance services 24.3%, blood bank services (13.5%), dentist services 5.4%, x-rays services 8.1% and other services 2.7%. Only 10.8% of the existence equipment in health facilities was adequate. The most basic problems and challenges found in health facilities were unsuitability of work environment 51.4%, deficit in medical devices 35.1%, deployment of contractors and health promoters 32.4%, no ambulance during summer days where scorpion and snake bites is more 32.4%, no treatment available during rainy season days 29.7%, un-continuity of electricity and water 21.6%, no health insurance 16.2% and building maintenance 5.4%.
Conclusion: The results show that, although the average PHC performance is almost appropriate and some of the surveyed health facilities have very high performances, some low-income and deprived areas experience substantial challenges. It is recommended that PHC plans should be formulated across the country and then implemented according to the local health needs and priorities.
Sero-Prevalence of Syphilis Among Blood Donors in Port Sudan city, Sudan, 2016
Authors: Hassan A.A. AL , Abdalmajed M.A. , Mohamadeen Tahane Bashir , Mohamadeen Nagat Bashir 
Published: September 2022

Background: Several infectious diseases have been found to be associated with transfusion of blood and blood components. Studies conducted in many African countries indicate a high prevalence of blood-borne pathogens such as Syphills infections among healthy blood donors.
Objectives: This study conducted to determine the prevalence of syphills among blood donors and associated risk factors in Port Sudan city, 2016.
Materials and methods: Across sectional laboratory-based study conducted in Port Sudan city. A Blood donor in central blood bank in Port Sudan during the period between August-October-2016. The data was collected through a structured questionnaire. Data was analyzed using SPSS version 15.0.
Results: The prevalence of syphilis among blood donors were 13.24%. The risk factors associated with prevalence syphills were significantly the age group 40-49 years, hard workers, primary schools donors and blood donors who has two sex partnerships, p<0.05.
Conclusion: The overall prevalence of syphills among blood donors in Portsudan city is 13.2% which is high in comparison to prevalence of noticed studies was done in different areas in the country. The risk factors associated with prevalence syphills were significantly the age group 40-49 years, hard workers, primary schools donors and blood donors who have two sex partnerships. Early and accurate detection of cases and conduction of effective treatment as to stop the progression of disease which can be infective to others. In addition to Health education on blood donations and safe sex behaviors targeting sexually active population, particularly between 20-50years old.