bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blinded by ‘Fairness’: Why We Need (Strong) Procedural Safeguards in Screening Self-Dealing and Obtaining a Fair Price Is Not the Answer
Authors: Gözlügöl Alperen Afşin 
Published: April 2022

AbstractEx post court review of related party transactions (RPTs) is one of the main mechanisms to deal with the problem of value diversion in public companies via self-dealing and is extensively made use of in Delaware and until relatively recently in most continental European countries. Such court review has also become to be known as the ‘fairness test’ whose contours may change depending on the jurisdiction and contexts in which it is applied. This study takes issue with the court review of actualized transactions under certain standards from two different perspectives. Firstly, it is argued that the behavioral insights derived from studies by behavioral economists and psychologists suggest that a legal regime that solely depends on the court review of substantive merits of RPTs without any (strong) procedural safeguard may fail to create a robust regime against value diversion. Secondly, acknowledging that the court review of substantive merits of RPTs may be inevitable in some cases, the study then turns its attention to the fairness test itself that compares the terms of an RPT to an arm’s length transaction, and argues that such an objective test fails to fully prevent value diversion. Accordingly, a recalibration of the test and a new framework are proposed.
Cost of Intralesional Collagenase Clostridium Histiolyticum Therapy Versus Surgery for the Management of Peyronie's Disease: A Claims-Based Analysis (2009–2019)
Authors: Walton Eric L. , Quinn Timothy P. , Mulloy Evan , Patil Dattatraya , Mehta Akanksha 
Published: April 2022

Abstract

Background
Collagenase Clostridium histolyticum (CCH), which was approved by the FDA for the treatment of Peyronie's disease (PD) in 2013, may obviate the need for surgery but its historically high cost must be considered when offering CCH vs surgical intervention to affected patients.

Aim
To compare trends of intralesional injections vs surgical treatment for PD and assess the contemporary cost of treatment with CCH vs surgical intervention.

Methods
We reviewed 2009–2019 MarketScan Commercial Claims data to identify all men 18 years and older with PD. CPT and HCPCS codes were used to identify PD treatments for each patient. Associated insurance claims in USD were summed for each treatment type.

Outcomes
Total and out-of-pocket costs, as well as frequencies, for treatments were calculated on a yearly basis and the Cochran-Armitage test was used to compare frequencies before and after FDA approval of CCH.

Results
Of 89,205 men diagnosed with PD, 21,605 (24.2%) underwent treatment; most required only intralesional injections, however 1,519 (7.0%) received only surgical therapy and 1,951 (9.0%) required medical and surgical therapy. Intralesional CCH use sharply increased after its FDA-approval in 2013 with a concomitant fall of intralesional verapamil use. The use of both surgical plication and plaque grafting decreased steadily from 2009 to 2019. The median cost per patient for all 3 treatments increased over the study time-period: $1,856 to $3,196 for plication, $2,233 to $3,631 for plaque grafting, and $6,940 to $8,895 per cycle for CCH. Out-of-pocket median patient contribution for plication, plaque grafting, and per cycle intralesional CCH injection were similar over the study period and never exceeded $300.

Clinical Implications
CCH is significantly more expensive than any surgical treatment option, however, the out-of-pocket patient contribution for surgery and CCH are similar.

Strengths & Limitations
This study incorporated all procedure costs and is the most contemporary, comprehensive, and accurate reflection of overall and out-of-pocket costs to patients for surgical and intralesional PD therapies. We anticipate these data to allow for a more complete discussion between patients and providers regarding their care. The use of a commercial claims database prohibited assessment of post-procedural costs and treatment outcomes.

Conclusion
CCH use has increased significantly since its FDA approval in 2013 with out-of-pocket patient contribution comparable to surgical therapy despite significantly higher total treatment costs.
Avoiding Assumptions: Sexual Function in Transgender and Non-Binary Individuals
Authors: Whitney Natalia , Samuel Ankhita , Douglass Laura , Strand Nicolle K. , Hamidian Jahromi Alireza 
Published: April 2022

ABSTRACT

Background
As the field of gender-affirming care continues its advancement, a clinical gap in the definition and evaluation of sexual function in transgender and non-binary (TGNB) individuals is becoming increasingly apparent. Recent speculations propose the modification of cis-gender heteronormative sexual function measurement tools as a useful way to close this knowledge gap.

Methods
Although the use of previously validated tools creates an easier platform for modification, the assumption of cis-gender sexual function as baseline will further disrupt patient-provider relationships, leading to inaccurate scientific conclusions, and increase the healthcare barriers faced by this community.

Results
As the definition of health has grown to include sexual function, the responsibility of the physician has evolved to include the treatment of sexual dysfunction as well. Without the imminent establishment of a scientific definition of sexual function with an accompanying measurement tool, this lack of understanding continues a precedent that may further stigmatize and distance this population from healthcare. Although this challenge may seem daunting, it should be noted that this has been accomplished for both cis-gender heterosexual men and women. This failure to scrupulously address the needs of the TGNB community directly contradicts the medical profession’s revered values of equity and compassion. This branch of sexual medicine and gender-affirming care is critical for maximizing the quality of life as well as equity of the TGNB community to their cis-gender, heteronormative counterparts.

Conclusion
A careful, kinder, and more inclusive approach is necessary, and the TGNB community deserves optimized care which requires a uniquely developed definition of sexual function and the required measurement tools.
Archaeologists and Historic Railroad Resources in the United States
Authors: Polk Michael R. 
Published: April 2022

ABSTRACTArchaeological research of a railroad, although not dissimilar to researching the history of a place, has unique aspects that make it challenging for those not familiar with the subject. Four words are vital to understanding a railroad: economics, operations, infrastructure, and regulation. With exceptions, a railroad in the United States exists only with all four in place. An archaeologist should investigate each to complete a holistic picture, although each may not always be essential for complete understanding of a particular railroad project. The author briefly discusses these issues and then identifies types of relevant historical documents and select archaeological features important in understanding a railroad. A case study of Lampo, a Central Pacific Railroad section station operative from the 1880s to 1942, is included to highlight important links between document research, archaeology, and the key operative aspects of a railroad.
Learning from Null Effects: A Bottom-Up Approach
Authors: Alrababa’h Ala’ , Williamson Scott , Dillon Andrea , Hainmueller Jens , Hangartner Dominik , Hotard Michael , Laitin David D. , Lawrence Duncan , Weinstein Jeremy 
Published: April 2022

AbstractA critical barrier to generating cumulative knowledge in political science and related disciplines is the inability of researchers to observe the results from the full set of research designs that scholars have conceptualized, implemented, and analyzed. For a variety of reasons, studies that produce null findings are especially likely to be unobserved, creating biases in publicly accessible research. While several approaches have been suggested to overcome this problem, none have yet proven adequate. We call for the establishment of a new discipline-wide norm in which scholars post short “null results reports” online that summarize their research designs, findings, and interpretations. To address the inevitable incentive problems that earlier proposals for reform were unable to overcome, we argue that decentralized research communities can spur the broader disciplinary norm change that would bring advantage to scientific advance. To facilitate our contribution, we offer a template for these reports that incorporates evaluation of the possible explanations for the null findings, including statistical power, measurement strategy, implementation issues, spillover/contamination, and flaws in theoretical priors. We illustrate the template’s utility with two experimental studies focused on the naturalization of immigrants in the United States and attitudes toward Syrian refugees in Jordan.
Structure, Strategy and Self in Cultural Peripheries: Theorizing the Periphery in the Polish and Dutch Fashion Fields
Authors: Kuipers Giselinde , Holla Sylvia , Van Der Laan Elise 
Published: April 2022

AbstractThis article analyzes the creation of value in (semi-)peripheral fields, using interview (N=94) and ethnographic data of creatives, models and cultural intermediaries in Polish and Dutch fashion. Drawing on field theory and center-periphery theories we show that these peripheral fields have a distinct structure—peripheral worlds—marked by the dependence on foreign centers for goods, standards and consecration, in which actors employ field-specific peripheral strategies for pursuing value and success. Workers in the (semi-)periphery develop peripheral selves, marked by a “double consciousness”, simultaneously seeing themselves from a local perspective and through the eyes of “central” others. We theorize “peripheralness” as a dimension of social inequality, a continuum ranging from “most central” to “most peripheral”, that spring from transnational interdependencies; and offer building blocks for a theory of the periphery that connects structural conditions and personal experiences. This theory explains, among others, why peripheries are not the reverse of centers, why centers also need peripheries (though not as much as peripheries need centers), and why peripheral and semi-peripheral actors don’t leave for cultural hubs to “make it there”.
The association between low carbohydrate diet scores and cardiometabolic risk factors in Chinese adults
Authors: Wang Jiaqi , Lv Shuaishuai , Zhou Yutian , Sun Yan , Zhu Huichen , Yan Guochao , Wu Yan , Ma Yuxia 
Published: April 2022

AbstractEpidemiological studies on the association between the low carbohydrate diet (LCD) score and CVD risk factors have limited and inconsistent results. Data are from the baseline survey of Community-based Cohort Study on Nervous System Diseases. A total of 4609 adults aged ≥ 18 years were included in the study. Dietary data were assessed using a validated semi-quantitative FFQ. Multivariable logistic regression analyses were used to estimate relationships of three LCD scores with low HDL-cholesterol, high LDL-cholesterol, hypercholesterolaemia, hypertriacylglycerolaemia, impaired fasting glucose (IFG), high blood pressure and hyperuricaemia after adjusting for potential confounders. A higher LCD score was negatively associated with low HDL-cholesterol (OR: 0·65 (95 % CI 0·50, 0·83), P = 0·0001) and IFG (OR: 0·65 (95 % CI 0·51, 0·81), P = 0·001) after the final adjustment. However, there are sex differences in this result. Males in the highest quintile of the animal-based or plant-based LCD scores showed a decreased risk of low HDL-cholesterol, and females in the highest quintile of the animal-based or plant-based LCD scores showed a decreased risk of IFG than those in the lowest quintile of the LCD scores. These results suggest that sex differences should be considered when using LCD to treat dyslipidaemia and reduce fasting blood glucose.
Sudden sensorineural hearing loss and coronavirus disease 2019
Authors: Pool C , King T S , Pradhan S , Isildak H 
Published: April 2022

AbstractObjectiveTo determine if otolaryngologists and audiologists of the American Academy of Otolaryngology – Head and Neck Surgery have noticed an increase in the incidence of sudden sensorineural hearing loss during the coronavirus disease 2019 pandemic.MethodsA questionnaire was developed for the purpose of providing a cross-sectional descriptive analysis of perceived association between the coronavirus disease 2019 pandemic and an increase in the incidence of sudden sensorineural hearing loss.ResultsOf respondents, 63.0 per cent did not notice an increase in sudden sensorineural hearing loss during the coronavirus disease 2019 pandemic. There was a weak positive correlation between patients identified with sudden sensorineural hearing loss and the percentage of coronavirus disease 2019 positive patients reported by each medical care provider (Spearman correlation = 0.20, 95 per cent confidence interval = 0.05–0.33). There was no association between geographical location and perceived increase in sudden sensorineural hearing loss (p= 0.38).ConclusionThe majority of respondents did not perceive an increase in the incidence of sudden sensorineural hearing loss during the coronavirus pandemic, regardless of geographical region.
The effect of cochlear implant insertion technique on post-operative neural response telemetry and impedance in paediatric patients
Authors: Hashemi S B , Janipour M , Jahangiri R , Babaei A 
Published: April 2022

AbstractObjectiveThis study aimed to compare neural response telemetry and impedance between the round window and cochleostomy approaches for cochlear implantation.MethodsIn this case–control study, 64 patients aged less than 3.5 years underwent cochlear implantation via the round window or cochleostomy approach. Post-operative neural response telemetry and impedance were measured.ResultsThe impedance measurements at electrodes 1, 11 and 22 showed no significant differences between the two groups three months after implantation (p = 0.90, p = 0.08 and p = 0.37, respectively). Similar results were observed six months after implantation (p = 0.71, p = 0.65 and p = 0.70, respectively). There was no significant difference in neural response telemetry between the two groups after three months. The neural response telemetry of electrode 1 in the cochleostomy group (171.26 ± 19.81 μV) was significantly higher in comparison with that of electrode 1 in the round window group (161.97 ± 12.71 μV) after six months (p = 0.03). The neural response telemetry values for electrodes 11 and 22 did not show any significant difference after six months (p = 0.14 and p = 0.48, respectively).ConclusionBoth approaches provide equal stimulation of the cochlear nerve and impedance.
Magnetic resonance imaging findings in patients with idiopathic olfactory dysfunction and normal findings on nasoendoscopy
Authors: Tung I M , Misirovs R , Gardiner Q 
Published: April 2022

AbstractObjectiveIn presentations of anosmia or dysosmia, magnetic resonance imaging may be required to screen for intracranial pathology such as olfactory neuroblastomas and other intracranial masses impacting on the olfactory pathway. This study aimed to establish positive magnetic resonance imaging findings of anosmia or dysosmia for scans performed before the coronavirus disease 2019 pandemic.MethodsThe study examined the outcome of patients who presented with isolated olfactory dysfunction and who underwent magnetic resonance imaging between 2015 and 2019.ResultsOf the 131 patients, 41 (31.3 per cent) had normal scan findings, 50 (38.2 per cent) had insignificant paranasal mucosal disease and 6 (4.6 per cent) had mucosal thickening significant enough to require additional intervention. These interventions included repeat nasoendoscopy or commencement of intranasal or oral steroids. No patients had olfactory neuroblastoma.ConclusionOnly 4.6 per cent of the magnetic resonance imaging scans revealed abnormal findings related to anosmia or dysosmia, and none required ENT surgical intervention. None of the magnetic resonance imaging scans identified an olfactory neuroblastoma or intracranial masses impacting on the olfactory pathway.
Host transmission dynamics of first- and third-stage Angiostrongylus cantonensis larvae in Bullastra lessoni
Authors: Pai Tsung Yu , Meyer Wieland , Torpy Fraser R. , Donahoe Shannon L. , Ellis John , Malik Richard , Lee Rogan 
Published: April 2022

AbstractGiven the importance of angiostrongyliasis as an emerging infectious disease of humans, companion animals, and wildlife, the current study focused on the transmission dynamics of first- and third-stage larvae of the parasitic nematode, Angiostrongylus cantonensis. The migration of infective larvae and their subsequent distribution within the Lymnaeidae snail, Bullastra lessoni, were investigated over time using microscopic examination of histological sections and fresh tissue. Snails were divided into four anatomical regions: (i) anterior and (ii) posterior cephalopedal masses, (iii) mantle skirt and (iv) visceral mass. The viability of free-swimming third-stage larvae, after their release from snail tissues, was evaluated in vitro by propidium iodide staining and infectivity by in vivo infection of Wistar rats. Snails were sequentially dissected over time to assess the number and anatomical distribution of larvae within each snail and hence infer their migration pathway. Herein, ongoing larval migratory activity was detected over 28 days post-infection. A comparison of infection rates and the larval distribution within the four designated snail regions demonstrated a significant relationship between anatomical region and density of infective larvae, with larvae mostly distributed in the anterior cephalopedal mass (43.6 ± 10.8%) and the mantle skirt (33.0 ± 8.8%). Propidium iodide staining showed that free-swimming third-stage larvae retained viability for between 4 and 8 weeks when stored under laboratory conditions. In contrast to viability, larval infectivity in rats remained for up to 2 weeks only. Knowledge gained from the current work could provide information on the development of new approaches to controlling the transmission of this parasite.
Depressive symptoms predict the incidence of common chronic diseases in women and men in a representative community sample
Authors: Otten Daniëlle , Ernst Mareike , Werner Antonia M. , Tibubos Ana N. , Reiner Iris , Brähler Elmar , Wiltink Jörg , Michal Matthias , Nagler Markus , Wild Philipp S. , Münzel Thomas , König Jochem , Lackner Karl J. , Peiffer Norbert , Beutel Manfred E. 
Published: April 2022

AbstractBackgroundDepression, the most frequent and harmful mental disorder, has been associated with specific somatic diseases as the leading cause of death. The purposes of this prospective study were to predict incident chronic diseases based on baseline depressive symptoms and to test sex-dependent effects.MethodsIn a representative German community sample of over 12 000 participants, baseline depressive symptoms (assessed using the Patient Health Questionnaire-9) were tested as a predictor of new onset of cardiovascular disease (CVD), chronic obstructive lung disease, diabetes, cancer, and migraine at 5-year follow-up. To study disease incidence, we created subsamples for each chronic disease by excluding participants who already had the respective disease at baseline. Potential confounders were included in logistic regression models and sex-specific analyses were performed.ResultsControlling for demographic characteristics and loneliness, in men and women, baseline depressive symptoms were predictive of CVD, chronic obstructive lung disease, diabetes, and migraine, but not of cancer. When we additionally adjusted for metabolic and lifestyle risk factors, there was an 8% increase of chronic obstructive lung disease and migraine per point of depressive symptoms. There was a trend for CVD (4%; p = 0.053). Sex-sensitive analyses revealed trends for the relevance of depressive symptoms for CVD in men (p = 0.065), and for diabetes in women (p = 0.077).ConclusionsThese findings underscore the need to implement screening for depression in the treatment of major somatic illnesses. At the same time, depressed patients should be screened for metabolic and lifestyle risk factors and for somatic diseases and offered lifestyle interventions.
Building social capital through sport engagement: evidence for adults aged 50 years and older
Authors: Sánchez-Santos José Manuel , Rungo Paolo , Lera-López Fernando 
Published: April 2022

AbstractInvolvement in sports is considered a powerful way to generate social capital. However, the role of sport engagement in the development of social relationships of older adults has not received much attention. Remarkably, there is a lack of empirical evidence on the quality and diversity of social relations built through active sport participation and spectatorship. This paper attempts to assess the relationship between sport engagement and various measures of network social capital, including the extension and quality of social networks and the heterogeneity of personal relationships. Also, it proposes new and more informative measurements of an individual's quantity and quality of social ties. By analysing data from a survey in Spain (N = 600) and applying logistic regressions, the results show that sport participation and attendance at sporting events are closely related to different dimensions of network social capital. Concerning people who are not actively engaged in sports, more extensive social networks characterise those who frequently attend sporting events. In contrast, active sport participation is associated with the extensity and quality measures of social connectedness, the level of satisfaction with friends and the opportunity to enjoy close relationships. Therefore, this paper provides new evidence on how sport engagement may result in tighter and extensive networks for older adults and serve as support for emphasising sports, physical activity and leisure as strategies for maintaining and boosting older people's social and psychological health.
Enacting the babushka: older Russian women ‘doing’ age, gender and class by accepting the role of a stoic carer
Authors: Shadrina Anna 
Published: April 2022

AbstractThis article contributes to the debates about age-based practices of distinction that produce stable notions about the subjectivities of members of social categories and the social consequences of such categorisations for the subject. In Russia, a strong expectation that grandmothers will prioritise helping their adult daughters with child care and housework over their careers and personal lives shaped the social position of the babushka, an unpaid family carer dependent on the state and her children. When women can no longer maintain meaningful post-pension-age employment, they see the babushka figure as the dominant option on which to model their identities. Drawing on 20 biographical interviews with women aged 60 and over, the article explores their tactics of performing their ‘gendered age’ in various classed ways. The babushka identity encompasses two broad strategies of self-presentation: taking control over one's life by emphasising that it is one's deliberate choice to live as a post-professional and post-sexual subject, and downplaying one's own needs while contributing to the wellbeing of others. The article shows that for older Russian women who face sexism, ageism and the stigmatisation of poverty, denying their vulnerability to systemic marginalisation is a familiar way of seeking recognition and maintaining their sense of self-worth. It advances the empirical exploration of the agentic component of vulnerability by revealing how the denial of (inter)dependence is presupposed by the conditions of subject-formation.