bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative study of food integrity climate in Belgian and Saudi Arabian food businesses in view of their organisational characteristics
Authors: Alrobaish Waeel Salih , Jacxsens Liesbeth , Vlerick Peter 
Published: April 2022

SummaryManaging food integrity within a food business represents a novel dimension in food safety management. In this study, the prevailing food integrity climate of different food companies was analysed and compared across two distinct countries (Belgium and Saudi Arabia), and its relation with various organisational characteristics was examined. A quantitative questionnaire was filled up by the principal quality manager of forty‐three food companies. Results show that the overall food integrity climate in the participating Saudi Arabian (n = 15) and Belgian food companies (n = 28) was estimated as medium–high. Scores varied substantially across the different participating food organisations, but only slightly between the two countries. The companies’ certification status was found statistically significantly related to a higher perceived food integrity climate, in particular for ISO 9000 as well as FSSC 22000 in both countries and IFS only in the Saudi Arabian sample. It was also demonstrated that the prevailing food integrity climate is associated with the company’s product type or sector, but only in the Belgian participating food companies, since Belgian quality managers employed in plant‐based food companies estimated their food integrity climate higher than their counterparts in animal‐based food companies. This horizontal comparative study, based on an intercontinental quantitative assessment of food integrity performance in food companies, contributes to enhance the understanding of food integrity in relation to specific organisational characteristics of food businesses, offering both theoretical and practical implications.
Haematology laboratory parameters to assess efficacy of CD19‐, CD22‐, CD33‐, and CD123‐directed chimeric antigen receptor T‐cell therapy in haematological malignancies
Authors: Drumheller Bradley , Gebre Kirubel , Lockhart Brian , Margolskee Elizabeth , Obstfeld Amrom , Paessler Michele , Pillai Vinodh 
Published: April 2022

AbstractIntroductionChimeric antigen receptor (CAR) T cell products are available to treat relapsed/refractory B‐lymphoblastic leukaemia/lymphoma (B‐ALL), diffuse large B‐cell lymphoma, mantle‐cell lymphoma, and myeloma. CAR products vary by their target epitope and constituent molecules. Hence, there are no common laboratory assays to assess CAR T cell expansion in the clinical setting. We investigated the utility of common haematology laboratory parameters to measure CAR T cell expansion and response.MethodsArchived CellaVision images, absolute lymphocyte counts, and Sysmex CPD parameters spanning 1 month after CD19‐CAR, UCAR19, CD22‐CAR, CD33‐CAR, and UCAR123 therapy were compared against donor lymphocyte infused control patients. Additionally, CellaVision images gathered during acute EBV infection were analysed.ResultsCellaVision images revealed a distinct sequence of three lymphocyte morphologies, common among CD19‐CAR, CD22‐CAR and UCAR19. This lymphocyte sequence was notably absent in CAR T cell non‐responders and stem‐cell transplantation controls, but shared some features seen during acute EBV infection. CD19‐CAR engraftment kinetics monitored by quantitative PCR show an expansion and persistence phase and mirror CD19‐CAR ALC kinetics. We show other novel CAR T cell therapies (UCAR19, CD22‐CAR, CD33‐CAR and UCAR123) display similar ALC expansion in responders and diminished ALC expansion in non‐responders. Furthermore, the CPD parameter LY_WY fluorescence increased within the first week after CD19‐CAR infusion, preceding the peak absolute lymphocyte count (ALC) by 3.7 days.ConclusionAutologous and allogeneic CAR T cell therapy produce unique changes in common haematology laboratory parameters and could be a useful surrogate to follow CAR T‐cell expansion after infusion.
Portfolio returns and consumption growth covariation in the frequency domain, real economic activity, and expected returns
Authors: Piccotti Louis R. 
Published: April 2022

AbstractThe slope of the portfolio return and consumption growth cospectrum contains predictive information about future real economic activity, future recession probabilities, the risk aversion coefficient, and future expected returns. Commonly used economic variables do not subsume the predictive power of the cospectrum slope and although the interest rate term spread largely fails to predict the financial crisis, the set of cospectrum slopes predicts the crisis with a 75% probability. The cospectrum slope significantly improves the fit of long‐horizon expected return models and contains more significant predictive information than the current dividend yield.
Complications Associated with Metal Resin Fixed Complete Dentures Based on Implant Distribution
Authors: Karre Shivani , Kattadiyil Mathew T. , Lozada Jaime L. , AlHelal Abdulaziz 
Published: April 2022

AbstractPurposeTo compare prevalence and type of complications associated with metal resin fixed complete dentures based on implant distribution.Materials and methodsThis retrospective study included data collected for a period of 12 years for patients treated with maxillary and mandibular implant‐supported fixed complete dentures at Loma Linda University School of Dentistry. In total, 223 patient's charts were reviewed which included 100 maxillary and 123 mandibular fixed complete dentures. Implant distribution and prevalence of complications associated with each implant‐supported fixed complete denture were documented. Tooth delamination, the most common complication associated with fixed complete dentures, was compared between 2 implant distribution groups in each arch. Covariates including age, sex, opposing arch, cantilever occluding units, and number of implants were evaluated to determine their association with tooth delamination. Data and hypotheses were statistically analyzed using descriptive statistics along with logistic regression model. All tests of hypotheses were considered statistically significant at an alpha level of 0.05.ResultsIn the maxillary arch, some effect of the prevalence of tooth delamination was seen for the group that had implants placed posterior to canine eminence but it was not statistically significant. Denture tooth delamination had the highest prevalence among complications irrespective of implant distribution. Significant denture tooth delamination was seen for patients with opposing fixed complete dentures in comparison to patients with removable opposing arch prostheses.ConclusionsImplant distribution is not a significant factor related to metal resin fixed complete dentures. Opposing fixed complete dentures have a significantly higher association with denture tooth delamination.
Tunneling nanotubes and mesenchymal stem cells: New insights into the role of melatonin in neuronal recovery
Authors: Luchetti Francesca , Carloni Silvia , Nasoni Maria G. , Reiter Russel J. , Balduini Walter 
Published: April 2022

AbstractEfficient cell‐to‐cell communication is essential for tissue development, homeostasis, and the maintenance of cellular functions after injury. Tunneling nanotubes (TNTs) have emerged as a new important method of cell‐to‐cell communication. TNTs are primarily established between stressed and unstressed cells and can transport a variety of cellular components. Mitochondria are important trafficked entities through TNTs. Transcellular mitochondria transfer permits the incorporation of healthy mitochondria into the endogenous network of recipient cells, changing the bioenergetic profile and other functional properties of the recipient and may allow the recipient cells to recuperate from apoptotic processes and return to a normal operating state. Mesenchymal cells (MSCs) can form TNTs and transfer mitochondria and other constituents to target cells. This occurs under both physiological and pathological conditions, leading to changes in cellular energy metabolism and functions. This review summarizes the newly described capacity of melatonin to improve mitochondrial fusion/fission dynamics and promote TNT formation. This new evidence suggests that melatonin's protective effects could be attributed to its ability to prevent mitochondrial damage in injured cells, reduce senescence, and promote anastasis, a natural cell recovery phenomenon that rescues cells from the brink of death. The modulation of these new routes of intercellular communication by melatonin could play a key role in increasing the therapeutic potential of MSCs.
Exploring the association between oral tactile sensitivity measures and phenotypic markers of oral responsiveness
Authors: Mani Elisa , Ford Rebecca , Pierguidi Lapo , Spinelli Sara , Ramsey Imogen , Monteleone Erminio , Dinnella Caterina 
Published: April 2022

AbstractThis study investigated the individual variability in oral tactile sensitivity considering touch, by means of Von Frey Hair monofilaments (VFH) and spatial resolution, using the grating orientation test (GOT). The relationships of the two measures with 6‐n‐propylthiouracil (PROP) responsiveness and fungiform papillae density and size were investigated. One hundred and forty‐four subjects (48.6% women, aged 18–30) participated in the study. VFH and GOT thresholds were assessed by three‐down/one‐up staircase method. Responsiveness to 3.2 mM PROP was assessed on the general Labeled Magnitude Scale. Fungiform papillae density (FPD) and size were determined from automated counting. VFH thresholds appeared unsuitable to reveal individual variation in responsiveness to point‐pressure on the tongue. The frequency of GOT thresholds approximated a normal distribution and covered the whole range of variation, thus indicating an ability to measure individual variation in oral tactile sensitivity. No significant linear correlations were found between any of the oral tactile sensitivity measures and PROP responsiveness, FPD total and size class. VFH and GOT thresholds were not significantly associated. Agglomerative hierarchical clustering was used to classify participants for their PROP responsiveness, total FPD and GOT threshold. Three clusters were identified, C1 (n = 67), Cl2 (n = 42), and Cl3 (n = 35), differing for PROP responsiveness and FPD only. Results encourage future studies to explore association between GOT and both perception and preference for different food texture. Furthermore, deeper investigation of individual variability in sensitivity to different types of oral tactile stimuli would be helpful to capture differences in tactile sensitivity among the most sensitive individuals.
Exometabolomic analysis of susceptible and multi-drug resistant Pseudomonas aeruginosa
Authors: Koçak E. , Nigiz Ş. , Özkan E. , Erdoğan Kablan S. , Hazirolan G. , Nemutlu E. , Kır S. , Sağıroğlu M. , Özkul C. 
Published: April 2022

AbstractMultidrug resistant (MDR) Pseudomonas aeruginosa strains have recently become one of the major public health concerns worldwide leading to difficulties in selecting appropriate antibiotic treatment. Thus, it is important to elucidate the characteristics of MDR isolates. Herein, we aimed to determine the unique exometabolome profile of P. aeruginosa clinical isolates in monocultures that comprise high resistance to multiple antibiotics, and compare the differential metabolite profiles obtained from susceptible isolates by using GC/MS. Our results showed that partial least square-discriminant analysis (PLS-DA) score plot clearly discriminated the MDR and susceptible isolates indicating the altered exometabolite profiles, and highlighted the significantly enriched levels of trehalose and glutamic acid in MDR isolates. Expression of trehalose synthase (treS) was also 1·5-fold higher in MDR isolates, relatively to susceptible isolates. Overall, our study provides insights into the distinct footprints of MDR P. aeruginosa isolates in mono-culture.
Rhizobial HmuSpSym as a heme‐binding factor is required for optimal symbiosis between Mesorhizobium amorphae CCNWGS0123 and Robinia pseudoacacia
Authors: Huo Haibo , Zong Le , Liu Yao , Chen Wenfeng , Chen Juan , Wei Gehong 
Published: April 2022

AbstractNitrogen‐fixing root nodules are formed by symbiotic association of legume hosts with rhizobia in nitrogen‐deprived soils. Successful symbiosis is regulated by signals from both legume hosts and their rhizobial partners. HmuS is a heme degrading factor widely distributed in bacteria, but little is known about the role of rhizobial hmuS in symbiosis with legumes. Here, we found that inactivation of hmuSpSym in the symbiotic plasmid of Mesorhizobium amorphae CCNWGS0123 disrupted rhizobial infection, primordium formation, and nitrogen fixation in symbiosis with Robinia pseudoacacia. Although there was no difference in bacteroids differentiation, infected plant cells were shrunken and bacteroids were disintegrated in nodules of plants infected by the ΔhmuSpSym mutant strain. The balance of defence reaction was also impaired in ΔhmuSpSym strain‐infected root nodules. hmuSpSym was strongly expressed in the nitrogen‐fixation zone of mature nodules. Furthermore, the HmuSpSym protein could bind to heme but not degrade it. Inactivation of hmuSpSym led to significantly decreased expression levels of oxygen‐sensing related genes in nodules. In summary, hmuSpSym of M. amorphae CCNWGS0123 plays an essential role in nodule development and maintenance of bacteroid survival within R. pseudoacacia cells, possibly through heme‐binding in symbiosis.
A meta‐analysis of the effects of electronic performance monitoring on work outcomes
Authors: Ravid Daniel M. , White Jerod C. , Tomczak David L. , Miles Ahleah F. , Behrend Tara S. 
Published: April 2022

AbstractElectronic performance monitoring (EPM), or the use of technological means to observe, record, and analyze information that directly or indirectly relates to employee job performance, is a now‐ubiquitous work practice. We conducted a comprehensive meta‐analysis of the effects of EPM on workers (K = 94 independent samples, N = 23,461). Results provide no evidence that EPM improves worker performance. Moreover, findings indicate that the presence of EPM is associated with increased worker stress, regardless of the characteristics of monitoring. Findings also demonstrate that organizations that monitor more transparently and less invasively can expect more positive attitudes from workers. Overall, results highlight that even as advances in technology make possible a variety of ways to monitor workers, organizations must continue to consider the psychological component of work.
Order Reduction of Nonlinear Quasi-Periodic Systems Using Lyapunov–Perron Transformation
Authors: Subramanian Susheelkumar C. , Redkar Sangram 
Published: April 2022

Abstract
In this paper, multiple order reduction techniques for parametrically excited nonlinear quasi-periodic systems are presented. The linear time-varying part of the quasi-periodic system is transformed into a linear time-invariant form via the Lyapunov–Perron (L–P) transformation. The analytical computation of such a transformation is performed using an intuitive state augmentation and the normal forms technique. This L–P transformation is further utilized in analyzing the nonlinear part of the original quasi-periodic system. Using the L–P transformation, three-order reduction techniques are detailed in this work. First, a Guyan linear reduction method is applied to reduce the order. The second method is to determine a nonlinear projection based on the singular perturbation method. In the third technique, the method of Invariant Manifold is applied to identify a relationship between the dominant and nondominant system states. Furthermore, in this work, all three order reduction techniques are demonstrated on the class of commutative and noncommutative/Hills-type nonlinear quasi-periodic systems. The behavior of the reduced system states of the resulting solution is compared with the numerical integration results and their performance is studied using the error plots for each technique.
Cenozoic sediment bypass versus Laramide exhumation and erosion of the Eagle Ford Group: Perspective from modelling of organic and inorganic proxy data (Maverick Basin, Texas, USA)
Authors: Robinson Alexandra S. , Dale Annabel , Adatte Thierry , John Cédric M. 
Published: April 2022

Abstract
The Cenozoic unconformity above the Late Cretaceous carbonates within the Maverick Basin is a unique feature of Texas (USA). Hypotheses accounting for the unconformity include (1) Cenozoic sediment bypass, and (2) ~6400 m of erosion during the Laramide orogeny. Both hypotheses have different implications for the burial history of the Eagle Ford Group (EFG) and for our understanding of the Laramide orogeny. We generated clumped isotope data and organic maturation proxies from the same location. Carbonate clumped isotope temperatures obtained (113 ± 9 °C) represent recrystallization during burial and a minimum estimate of the maximum burial temperature. This constraint is significantly warmer than apparent organic temperatures derived using an Arrhenius equation (40–55 °C). Organic matter transformation and carbonate recrystallization respond to temperature over different time scales and therefore capture snapshots of the thermal history particular to the chemical reactions that control the respective processes. Using numerical forward modeling on the combination of two different temperature proxies, we derived a new hypothesis: ~2800 m of Cenozoic sediments were accumulated and then eroded during late Laramide compression. This is significantly less erosion than previous estimates, indicating the impact of the Laramide orogeny in the basin may have been less severe than previously thought.
Oceanic isostasy as a trigger for the rift-to-drift transition
Authors: Conder James A. 
Published: April 2022

AbstractA long-standing missing link in our understanding of the Wilson cycle is how a continental rift transitions to seafloor spreading. The variety of rift structures and transition timings at rift margins do not easily lend themselves to some specific degree of strain and/or magmatism as the tipping point. Invariably ignored in the process, but a potential key to the conundrum, is the isostatic response that comes with ocean loading during and after inundation. Ocean mass redistribution on variably subsiding crust drives flow in the asthenosphere in much the same way a growing icecap drives a corresponding outward mantle flow. This flow alters mantle tractions of the rift system, with disappearance of basal resistance, and even adds a push to the rifting process. Evidence for ocean inundation facilitating self-sustained seafloor spreading is observed in the Atlantic, around the Afar triple junction, and elsewhere, indicating that the ocean should not be considered simply incidental to the creation of oceanic basins.
Relationship between glacial CO2 drawdown and mercury cycling in the western South Atlantic: An isotopic insight
Authors: Figueiredo Thiago S. , Bergquist Bridget A. , Santos Thiago P. , Albuquerque Ana Luiza S. , Silva-Filho Emmanoel Vieira 
Published: April 2022

Abstract
Pronounced changes in the deep Atlantic circulation occurred during glacial stages, which affected the global carbon distribution and the biogeochemical cycles of other elements. Previous studies demonstrated that oceanic mercury is sensitive to the same kind of processes that affect the carbon cycle in glacial–interglacial time scales. We used Hg isotopes to elucidate Hg cycling during the last two glacial–interglacial transitions in the subtropical western South Atlantic. Mass-dependent fractionation (MDF, δ202Hg) and mass-independent fractionation (MIF, Δ199Hg) show significant variations and shift toward higher and lower values during the penultimate and Last Glacial Maximum periods, respectively. δ202Hg variability is in-phase with periods of lower atmospheric CO2 and benthic δ13C, suggesting that MDF is affected by the same mechanisms that led to atmospheric CO2 drawdown during glacial stages. In contrast, terrestrial Hg input to our site, boosted by lower sea level and exposure of the continental shelf, dominates the Δ199Hg variability.
Physical Basis of Functioning of Antifreeze Protein
Authors: Melnik B. S. , Finkelstein A. V. 
Published: April 2022

Abstract
Antifreeze proteins, expressed in cold-blooded organisms, prevent ice formation in their bodies, and thus help them to survive in extremely cold winter temperatures. However, the mechanism of action of these proteins is still not clear. In any case, it is not simply a decrease in the temperature of normal ice formation. In this work, investigating the ice-binding protein (a mutant form of the antifreeze protein cfAFP from the spruce budworm Choristoneura fumiferana, which overwinters in needles), we showed that this antifreeze protein does not at all lower the freezing point of water and, paradoxically, increases the melting point of ice. On the other hand, calculations based on the theory of crystallization show that at temperatures of 0 ° to –30°C ice can only appear on surfaces that contact water, but not in the body of water. These facts suggest a new perspective on the role of antifreeze proteins: their task is not (as it is commonly believed) to bind with nascent ice crystals already formed in the organism and stop their growth, but to bind to those surfaces, on which ice nuclei can appear, and thus completely inhibit the ice formation in supercooled water or biological fluid.
$$b\rightarrow s\ell ^+\ell ^-$$ global fits after $$R_{K_S}$$ and $$R_{K^{*+}}$$
Authors: Algueró Marcel , Capdevila Bernat , Descotes-Genon Sébastien , Matias Joaquim , Novoa-Brunet Martín 
Published: April 2022

AbstractWe present an up-to-date complete model-independent global fit to $$b\rightarrow s\ell \ell $$

b
→
s
ℓ
ℓ

observables that confirms patterns of New Physics able to explain the data. We include the recent LHCb measurements of $$R_K$$

R
K

, $$R_{K_S}$$

R

K
S

, $$R_{K^{*+}}$$

R

K

∗
+

, $$B_s \rightarrow \phi \mu ^+\mu ^-$$

B
s

→
ϕ

μ
+

μ
-

and $$B_s\rightarrow \mu ^+\mu ^-$$

B
s

→

μ
+

μ
-

in our analysis, which now includes 254 observables. This updates our previous analyses and strengthens their two main outcomes. First, the presence of right-handed couplings encoded in the Wilson coefficients $${{\mathcal {C}}}_{9'\mu }$$

C

9
′

μ

and $${{\mathcal {C}}}_{10'\mu }$$

C

10
′

μ

remains a viable possibility. Second, a lepton flavour universality violating (LFUV) left-handed lepton coupling ($${{\mathcal {C}}}_{9\mu }^{\mathrm{V}}=-{{\mathcal {C}}}_{10\mu }^{\mathrm{V}}$$

C

9
μ

V

=
-

C

10
μ

V

), often preferred from the model building point of view, accommodates the data better if lepton-flavour universal New Physics is allowed, in particular in $${{\mathcal {C}}}_{9}^{\mathrm{U}}$$

C

9

U

. We observe that the LFUV observable $$Q_5$$

Q
5

offers a very interesting possibility to separate both types of scenarios.
Sum-Connectivity Coindex of Graphs under Operations
Authors: Ibraheem Muhammad , Bonyah Ebenezer , Javaid Muhammad 
Published: April 2022

Topological indices or coindices are mathematical parameters which are widely used to investigate different properties of graphs. The operations on graphs play vital roles in the formation of new molecular graphs from the old ones. Let

Γ

be a graph we perform four operations which are

S

,

R

,

Q
,
and
T

and obtained subdivisions type graphs such that

S

Γ

,

R

Γ

,

Q

Γ

, and

T

Γ

, respectively. Let

Γ

1

and

Γ

2

be two simple graphs; then,

F

-sum graph is defined by performing the Cartesian product on

F

Γ

1

and

Γ

2

; mathematically, it is denoted by

Γ

1
+
F

Γ

2

, where

F
∈

S
,
R
,
Q
,
T

. In this article, we have calculated sum-connectivity coindex for

F

-sum graphs. At the end, we have illustrated the results for particular

F

-sum graphs with the help of a table consisting of numerical values.