bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of novel agents in patients with nephropathy associated with POEMS syndrome
Authors: Cheng Shuiqin , Huang Li , Fan Wenjing , Liang Dandan , Zhu Xiaodong , Jiang Song , Ge Yongchun 
Published: February 2022

Abstract
Objective
To evaluate the clinical characteristics and outcomes of patients with nephropathy associated with POEMS syndrome who received novel agents in combination with dexamethasone therapy, and renal pathological changes based on repeat biopsy in some patients after these novel-agent-based therapies.

Methods
The records of patients with nephropathy associated with POEMS syndrome in a single hospital from May 2017 to February 2021 were retrieved and studied in detail. All the patients received four cycles of initial novel-agent-based regimens such as bortezomib and dexamethasone (BD) or thalidomide plus dexamethasone (TD) or lenalidomide plus dexamethasone (RD) treatment. We further evaluated the pathological efficacy of these novel agents by repeat renal biopsy.

Results
Twelve patients with an average age of 48.6 ± 8.3 years diagnosed with nephropathy associated with POEMS syndrome were enrolled in this study. The duration from disease onset to renal biopsy was 28(8.3 ~ 54.5) months. All patients achieved good clinical responses in different degree after four cycles of initial novel agents in combination with dexamethasone therapy. After the treatment with novel-agent-based regimens, the levels of proteinuria decreased in most patients and were negative in five patients. The levels of serum creatinine (SCr) decreased in ten patients. Serum M protein was negative in four patients and still positive in the other eight patients. The levels of serum vascular endothelial growth factor (VEGF) were detected in seven patients, which were all decreased. The levels of interleukin-6 (IL-6) were detected in eight patients, which were also decreased. Repeat biopsies were performed after four cycles of novel-agent-based therapies in four patients who were all treated with BD treatment. Mesangiolysis, mesangial cells proliferation, endothelial cells proliferation, subendothelial space widening and acute renal tubulointerstitial lesions improved, the chronic renal tubulointerstitial lesions were stable.

Conclusions
Novel agents improved clinical manifestations in patients with nephropathy associated with POEMS syndrome. In addition, novel-agent-based regimens such as BD treatment improved renal pathological manifestations, which suggested that novel agents could improve renal prognosis of the patients from the perspective of renal pathology.
Reciprocal relationship between multicultural adolescents’ depression and life satisfaction: a random intercept cross-lagged panel model for 3-wave panel data
Authors: Lee Hyeyeon , Lee Hyeonkyeong , Kim Youlim , Lee Mikyung , Park Chang Gi 
Published: February 2022

AbstractMulticultural adolescents (MA) in Korea experience higher depression and lower life satisfaction compared to Korean native adolescents. To consider appropriate interventions, this study investigates the cross-lagged effect between life satisfaction and depression among these adolescents. Secondary data from the Multicultural Adolescents Panel Survey, which is a nationally representative sample, was analyzed. Data from the 3rd (T1, elementary school), 5th (T2, middle school), and 7th (T3, high school) waves (2013–2017) were used. Altogether, 1,239 MA were included in the sample for analysis; the mean age at T1 was 11.97 (± 0.36) years. The ten-item Depression Scale Questionnaire was used to measure depression, and the three-item Happiness Scale was used to measure life satisfaction. The random intercept cross-lagged panel model was conducted to estimate within-person autoregressive and cross-lagged effects. Life satisfaction and depression had a reciprocal relationship from T1 to T2, while only life satisfaction had a lagged effect from T2 to T3. Life satisfaction’s lagged effect dominated that of depression. The cross-lagged effect size of depression from T1 to T2 was larger than that from T2 to T3, and that of life satisfaction from T2 to T3 was larger than that from T1 to T2. Low life satisfaction in MA continues over time. Depression is not persistent, but if experienced in elementary school, it leads to low life satisfaction in middle school and depression in high school. The findings suggest that early intervention for depression in elementary school can reduce its negative effect MA’s life satisfaction.
Parental self-efficacy and satisfaction with parenting as mediators of the association between children’s noncompliance and marital satisfaction
Authors: Matalon Carmit , Turliuc Maria Nicoleta 
Published: February 2022

AbstractParents of young children who exhibit behavioral problems often experience lower marital satisfaction. In the present study we aimed to explore the association between preschool children's noncompliant behavior and marital satisfaction, and to explain it through the mediating role of parental self-efficacy and satisfaction with parenting. Participants were 188 married Israeli couples with a typically developing child aged 3 to 6, selected in a convenience sample. Mothers and fathers independently completed measures of child’s behavior, marital satisfaction, parental self-efficacy, and satisfaction with parenting. Data were collected between September 2019 and February 2020 and were analyzed using the common fate model (CFM). Results indicate a direct, negative association between child's noncompliant behavior and marital satisfaction, which was fully explained by parental self-efficacy and satisfaction with parenting. The study suggests that both parents are affected by their young child’s noncompliance, with a spillover effect from the parent–child relationship into the marital relationship. The findings highlight the importance of early treatment of children's noncompliance and indicate that interventions aimed at enhancing parents’ self-efficacy and satisfaction, as well as the inclusion of both parents in treatment, may be beneficial.
A Kirchhoff Type Equation in $$\pmb {\mathbb {R}}^{N}$$ Involving the fractional (p, q)-Laplacian
Authors: Ambrosio Vincenzo 
Published: February 2022

AbstractIn this paper, we deal with the following class of fractional (p, q)-Laplacian Kirchhoff type problem: $$\begin{aligned} \left\{ \begin{array}{ll} \left( 1+[u]_{s,p}^{p}\right) (-\Delta )_{p}^{s}u+ \left( 1+[u]^{q}_{s, q}\right) (-\Delta )_{q}^{s}u + V(\varepsilon x) (|u|^{p-2}u + |u|^{q-2}u)= f(u) &{} \text{ in } \mathbb {R}^{N}, \\ u\in W^{s, p}(\mathbb {R}^{N})\cap W^{s,q}(\mathbb {R}^{N}), \quad u>0 \text{ in } \mathbb {R}^{N}, \end{array} \right. \end{aligned}$$

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Geochemical modeling and isotopic approach for delineating water resources evolution in El Fayoum depression, Egypt
Authors: Srour E. , Hussien R. A. , Moustafa W. M. 
Published: February 2022

AbstractIn this study, an attempt was made to understand the hydrogeochemical processes controlling water resources (surface and groundwater) evolution in El Fayoum depression, Egypt. Hydrochemical, inverse geochemical modeling integrated with environmental isotopes was applied. Forty-three surface and groundwater samples were collected and analyzed for major chemistry (cations, anions) and environmental stable isotopes (δ18O, δD). The ionic sequence based on relative molar proportions for cations was Na+ > Ca2+ > Mg2+ > K+ and Na+ > Mg2+ > Ca2+ > K+ for surface and groundwater, respectively and for anions was HCO3− > Cl− > SO42− for all water samples. δ18O and δD relationship plot on a typical evaporation line, enhance potential evaporation of recharging water prior to infiltration. Saturation index estimation revealed that water resources were affected by carbonate and evaporites minerals dissolution and supersaturated with Goethite, Gibbsite and Barite minerals. Inverse geochemical modeling using PHREEQC was used to identify water resources evolution in the study area through two flow paths A, B. The inverse model was constrained so the primary mineral phase including calcite, Aragonite, Anhydrite and Gypsum with Carbon dioxide (gas) are constrained to dissolve until they reach saturation, Whereas H2(g), hydrogen sulphide (gas) and O2(g) are constrained to out gas in all models for flow path (A). For flow path (B), Dolomite, Anhydrite and Gypsum are tend to dissolve with carbon dioxide (gas), H2(g) and O2(g) gases tend to outgassed. Finally, two processes controlling water resource evolution; carbonate and evaporites dissolution and development of cation exchange process through the aquifer system.
Improved Stability and Practicality for Synthesis of 4-Borono-2-[18F]fluoro-l-phenylalanine by Combination of [18O]O2 Single-Use and [18F]CH3COOF Labeling Agents
Authors: Naka Sadahiro , Watanabe Toshimitsu , Kanai Yasukazu , Watabe Tadashi , Tatsumi Mitsuaki , Kato Hiroki , Shimosegawa Eku , Hatazawa Jun 
Published: February 2022

Abstract
Purpose
4-Borono-2-[18F]fluoro-l-phenylalanine ([18F]FBPA) synthesized with [18F]F2, produced using the 18O(p, n)18F reaction, has been reported for increasing radioactivity. However, a dedicated system and complex procedure is required to reuse the costly [18O]O2 gas; also, the use of [18F]F2 as a labeling agent reduces the labeling rate and radiochemical purity. We developed a stable and practical method for [18F]FBPA synthesis by combining [18F]F2, produced using a [18O]O2 single-use system, and a [18F]CH3COOF labeling agent.

Methods
The produced [18F]F2 was optimized, and then [18F]FBPA was synthesized. For passivation of the target box, 0.5% F2 was pre-irradiated in argon. Gaseous products were discarded; the target box was filled with [18O]O2 gas, and then irradiated (first irradiation). Then, the [18O]O2 gas was discarded, 0.05–0.08% F2 in argon was fed into the target box, and it was again irradiated (second irradiation). The [18F]F2 obtained after this was passed through a CH3COONa column, converting it into the [18F]CH3COOF labeling agent, which was then used for [18F]FBPA synthesis.

Results
The mean amount of as-obtained [18F]F2 was 55.0 ± 3.3 GBq and that of as-obtained [18F]CH3COOF was 21.6 ± 1.4 GBq after the bombardment. The radioactivity and the radiochemical yield based on [18F]F2 of [18F]FBPA were 4.72 ± 0.34 GBq and 12.2 ± 0.1%, respectively. The radiochemical purity and molar activity were 99.3 ± 0.1% and 231 ± 22 GBq/mmol, respectively.

Conclusion
We developed a method for [18F]FBPA production, which is more stable and practical compared with the method using [18O]O2 gas-recycling and [18F]F2 labeling agent.
In-office hysteroscopic removal of retained or fragmented intrauterine device without anesthesia: a cross-sectional analysis of an international survey
Authors: Vitale Salvatore Giovanni , Di Spiezio Sardo Attilio , Riemma Gaetano , De Franciscis Pasquale , Alonso Pacheco Luis , Carugno Jose 
Published: February 2022

AbstractTo investigate about the opinions of gynecologists regarding the in-office hysteroscopic removal of retained or fragmented intrauterine device (IUD) without anesthesia. An online survey was made available to gynecologists who routinely performed in-office hysteroscopy. Five areas of interest were analyzed: average number of hysteroscopic procedures performed without anesthesia, availability on their local market of the different types of hormonal and non-hormonal IUDs, reasons for the hysteroscopic removal of the IUD, types of IUDs that were more commonly found retained or fragmented and, overall difficulty of the hysteroscopic removal. A total of 419 surgeons voluntarily responded the survey, of which 19 were excluded for not performing in-office hysteroscopy. The most commonly available IUD was the Levonorgestrel-based Mirena (Bayer Healthcare, Germany) or similar, (399/400, 99.7%), followed by Copper T (Paragard, CooperSurgical INC, United States) (397/400, 99.2%), Multiload (234/400, 58.5%) and Jaydess (Bayer Healthcare, Germany) (227/400, 56.7%). The intracavitary retention of the IUD with (44.5%, 178/400) and without (42.2%, 169/400) visible strings accounted as the most common reason for undergoing hysteroscopic IUD removal. Copper T IUD was the most common intracavitary retained (297/400, 74.2%) as well as fragmented device (236/400, 59.9%). The in-office hysteroscopic removal of the IUD was considered an easy procedure by almost all the operators (386/400, 96.5%). In-office hysteroscopy without anesthesia is seen as a feasible and easy approach to remove retained or fragmented IUDs inside the uterine cavity or cervical canal. While the Levonorgestrel-based IUD is the most commercialized, Copper T IUDs are the most commonly found retained or fragmented.
Nanocoating of microbial fuel cell electrodes for enhancing bioelectricity generation from wastewater
Authors: Attia Yasser A. , Samer Mohamed , Mohamed Mahmoud S. M. , Moustafa Elshaimaa , Salah Mohamed , Abdelsalam Essam M. 
Published: February 2022

AbstractMicrobial fuel cells (MFCs) are devices where bacteria generate electrical energy by oxidizing organic matter in wastewater. The implementation of MFCs on a commercial scale is limited due to electrode resistances, which are one of the key factors limiting electricity generation. This study presents a method to maximize the electrical power production from MFCs by coating the electrodes using nanomaterials which leads to prototyping novel electrodes having higher electrical conductivity than common electrodes. The voltage reached 1.234 V directly after operating the MFCs, with nanocoated electrodes, and showed voltage stability till the end of the 140 h interval with a peak value of 1.367 V with a maximum areal power density of 116 mW m−2 and a maximum volumetric power density of 15.6 mW m−3. However, the voltage of the control (without coating) was steadily increased to 0.616 V after 22 h with a maximum areal power density of 23.6 mW m−2 and a maximum volumetric power density of 3.2 mW m−3 then showed voltage stability till the end of the 140 h interval. It was found that the coulombic efficiency of the MFCs where its electrodes are coated with graphitic carbon nitride nanosheets was higher than graphene, carbon nanotubes, and the control in a descending order, respectively. By this method, it is possible to improve the electrical conductivity of the MFCs which results in increasing the generated electrical power by 4.9 times the conventional method.
Self-Assembly 3D Porous Crumpled MXene Spheres as Efficient Gas and Pressure Sensing Material for Transient All-MXene Sensors
Authors: Yang Zijie , Lv Siyuan , Zhang Yueying , Wang Jing , Jiang Li , Jia Xiaoteng , Wang Chenguang , Yan Xu , Sun Peng , Duan Yu , Liu Fangmeng , Lu Geyu 
Published: February 2022

Abstract
Environmentally friendly degradable sensors with both hazardous gases and pressure efficient sensing capabilities are highly desired for various promising applications, including environmental pollution monitoring/prevention, wisdom medical, wearable smart devices, and artificial intelligence. However, the transient gas and pressure sensors based on only identical sensing material that concurrently meets the above detection needs have not been reported. Here, we present transient all-MXene NO2 and pressure sensors employing three-dimensional porous crumpled MXene spheres prepared by ultrasonic spray pyrolysis technology as the sensing layer, accompanied with water-soluble polyvinyl alcohol substrates embedded with patterned MXene electrodes. The gas sensor achieves a ppb-level of highly selective NO2 sensing, with a response of up to 12.11% at 5 ppm NO2 and a detection range of 50 ppb–5 ppm, while the pressure sensor has an extremely wide linear pressure detection range of 0.14–22.22 kPa and fast response time of 34 ms. In parallel, all-MXene NO2 and pressure sensors can be rapidly degraded in medical H2O2 within 6 h. This work provides a new avenue toward environmental monitoring, human physiological signal monitoring, and recyclable transient electronics.
Demographic change and private savings in India
Authors: Jain Neha , Goli Srinivas 
Published: February 2022

AbstractIndia is on the edge of a demographic revolution with a rapidly rising working-age population. For the first time in this study, we investigate the role of the rising working-age population on per capita small savings in post offices and banks net of socio-economic characteristics using state-level panel data compiled from multiple sources for the period 2001–2018. Our comprehensive econometric assessment with multiple robustness checks provides three key findings: (1) per capita private savings is increasing because of India’s growing working-age population; thus, the ‘economic life cycle hypothesis’ is evidentially supported; (2) the demographic factors contribute around one-fourth of the per capita private savings inequality across Indian states; and (3) the demographic window of economic opportunity for India can yield maximum benefits in terms of private savings when accompanied by favourable socio-economic policies on education, health, gender equity, and economic growth.
NMR study of the inclusion complexes of β-cyclodextrin with diphenhydramine, clonidine and tolperisone
Authors: Zhumakova Symbat , Ten Assel , Zharkynbek Tolganay , Yu Valentina , Seilkhanov Tulegen , Basharimova Anna , Bayazit Sarah , Aydemir Murat , Zazybin Alexey 
Published: February 2022

Abstract
Forming complexes with β-cyclodextrin can enhance stability, dissolution rate, solubility, and bioavailability of an active pharmaceutical ingredient. In this study, the inclusion behavior between β-cyclodextrin (β-CD) and diphenhydramine, clonidine, and tolperisone in DMSO-d6 was investigated using NMR spectroscopy. 1H, 13C, COSY, HMQC, and ROESY data were applied to determine the structure of inclusion complexes, and molecular docking analysis was engaged to identify the most favorable host–guest interactions in the inclusion complexes. Complexation of β-CD with diphenhydramine, clonidine, and tolperisone is accompanied by the insertion of a molecular fragment of the guest molecule, one molecule of diphenhydramine and tolperisone, and two molecules of clonidine, into the inner sphere of one host molecule. The reported study provides useful information for the potential application of the complexation of β-CD with diphenhydramine, clonidine, and tolperisone. This may be a good strategy for the development of solid pharmaceutical dosage forms based on β-CDs as a drug delivery system.

Article highlights

The inclusion complexes of β-CD and diphenhydramine, clonidine, and tolperisone were synthesized and analyzed using 1Н, 13С, COSY, HMQC, and ROESY spectroscopy.

Diphenhydramine, clonidine, and tolperisone interact with β-CD with the formation of stable 1:1 stoichiometric complexes for β-CD:diphenhydramine and β-CD:tolperisone, and 1:2 stoichiometric complex for β-CD:clonidine.

Possible structures of the inclusion complexes between β-CD and diphenhydramine, clonidine, and tolperisone were determined using molecular docking in the software AutoDock 4.0.
Sexual Risk Behaviors Among Youth in Soweto, South Africa During the COVID-19 National Lockdown
Authors: Mulaudzi Mamakiri , Kiguwa Peace , Zharima Campion , Otwombe Kennedy , Hlongwane Khuthadzo , Dietrich Janan J. 
Published: February 2022

Abstract

Background
Assessment of sexual risk behavior among youths is crucial for HIV prevention strategies. However, the literature on sexual behavior in youth during the COVID-19 pandemic is sparse.

Aim
This study surveyed sexual risk behavior among youth in Soweto, South Africa during the COVID-19 pandemic national lockdown in 2020.

Methods
We conducted a cross-sectional telephonic survey on socio-demographics and HIV risk behaviors among youth aged 18–24 years during level 3 of the lockdown. Frequencies and their respective percentages were determined for categorical variables and stratified by biological sex. Chi-square analysis was used to compare categorical variables. All data were analyzed using SAS software.

Outcomes
A risk assessment for HIV questionnaire was used to assess sexual risk behaviors. Also, substance use was assessed through a developed yes/no questionnaire.

Results
Of the 129 participants, 83.0% (n = 107) had a sexual partner; 52% of those who had a sexual partner were females, 60.7% (65/107) had one current sexual partner and 39.2% (42/107) had more than 1 sexual partner. Most reported sex within 1 week (54.2%, n = 58/107) and 30.8% within a month (30.8%, n = 33/107). Sex was with a dating partner (86.0%, n = 92/107) and 63% used a condom during last sexual contact. Males were more likely than females to have one-night stand sexual partners (23.5% vs 7.1%; P = .0176), make weekly changes in partners (17.7% vs 5.4%; P = .0442) and used condoms with their partners (92.2% vs 53.6%; P &lt; .0001) during last sexual contact. The majority reported alcohol use (69.0%, n = 89/129). Males were more likely than females to use alcohol on a weekly basis (21.4% vs 6.4%; P = .0380). About 55.9% had penetrative sex under the influence of substances.

Clinical Translation
This study gives an insight to the sexual risk behaviors among young people which is crucial for HIV prevention interventions.

Strength & Limitations
This was the first study investigating sexual behavior in youth during the COVID-19 pandemic. The main limitations of this study relate to the sample size and sampling strategy. As the sample was not representative of the population of young people in Soweto and South Africa, the results cannot be generalized. However, the findings have relevance for future research in HIV prevention for young people in other settings in South Africa.

Conclusions
Interventions on promoting sexual health and reducing HIV risk behavior such as sex following alcohol consumption in young people are needed, especially during a pandemic such as COVID-19.