bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatic recognition of craquelure and paint loss on polychrome paintings of the Palace Museum using improved U-Net
Authors: Yuan Quan , He Xiang , Han Xiangna , Guo Hong 
Published: November 2022

Abstract
Craquelure is the most common defect on ancient polychrome paintings, which may deteriorate further to paint loss. Previous image processing methods, which can accurately recognize paint loss, have limited precision and efficiency in segmenting craquelure. This paper proposes a semantic segmentation method, Res-UNet, for the recognition of craquelure and paint loss in the Palace Museum, Beijing. The residual structure of ResNet-50 enables the avoidance of network degradation, and image features can be fully extracted. Using the unique skip connection module of U-Net, features of different levels are fused to improve segmentation accuracy and provide smoother craquelure edges. Three loss functions are combined to accelerate stable convergence. The model was trained on a newly built dataset based on 600 images, and tested on images both in and out of the dataset. Experimental results supported by statistical tests show that Res-UNet is a capable method of craquelure recognition, with an accuracy rate of 98.19%, and mean pixel accuracy = 93.67%. Hence, the proposed hybrid approach is a promising tool to support the preservation and restoration of valuable traditional Chinese polychrome architectural paintings.
Realization of college sports multimedia teaching platform based on cloud computing motion image analysis
Authors: Li Jiang 
Published: November 2022

Abstract
In order to improve the ability of college sports multimedia teaching, dynamic image analysis and data management, a design scheme of college sports multimedia teaching platform based on cloud computing mode was proposed. The method of dynamic integrated allocation and fuzzy scheduling of multimedia teaching resources is adopted. The characteristic values and dynamic analysis of moving images of college sports multimedia teaching are extracted. By using hierarchical structure and image integration scheduling method, this paper analyzes the characteristic values of image analysis in college sports multimedia teaching and dynamic analysis of moving images. By using the methods of adaptive cooperative control and resource matching scheduling, the control objective allocation function of college sports multimedia teaching and dynamic analysis of moving images is constructed. The correlation of image information resources in college sports multimedia teaching is mined by using the ultra micro pixel feature matching method, and a big data mining and information fusion model for college sports multimedia education and dynamic analysis of motion images is constructed. Use cloud computing technology to provide users with various services, and use machine learning technology to analyze teaching data. Through priority scheduling and dynamic allocation methods, the dynamic allocation of teaching resources and dynamic analysis of moving images in the process of college sports multimedia teaching are realized. In ASP NET technology, cloud computing and Silverlight technology have realized the software development and design of college sports multimedia teaching platform under the motion image analysis mode. The simulation results show that using this method to design the college sports multimedia teaching platform under the motion image analysis mode can improve the dynamic distribution and mining ability of image information resources in college sports multimedia education. The platform has a high level of data fusion and a strong ability to analyze motion images.
Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio are positively correlated with disease activity of bullous pemphigoid
Authors: Sun Chao , Li Xiaoguang , Qian Hua , Liang Guirong , Xiang Ruiyu , Zhao Chenjing , Li Zhiliang , Li Suo , Jing Ke , Wang Yuan , Zhang Hanmei , Feng Suying 
Published: November 2022

Abstract
Bullous pemphigoid (BP) is a complex inflammatory process with elevated levels of autoantibodies, eosinophils, neutrophils, and various cytokines. Hematological inflammatory biomarkers can reflect inflammatory state in various diseases. Up to now, the correlations of hematological inflammatory biomarkers and disease activity of BP remain unknown. The purpose of this study was to clarify the associations between hematological inflammatory biomarkers and disease activity of BP. The levels of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), platelet-to-neutrophil ratio (PNR) and mean platelet volume (MPV) of 36 untreated BP patients were detected by routine blood tests, and their correlations with clinical characteristics of BP were statistically analyzed. The Bullous Pemphigoid Disease Area Index (BPDAI) was used to measure disease activity of BP. The mean levels of NLR, PLR, PNR and MPV in 36 untreated BP patients were 3.9, 157.9, 45.7 and 9.4 fl, respectively. The levels of NLR were positively correlated to BPDAI Erosion/Blister Scores (p < 0.01). The levels of NLR and PLR were both positively correlated to BPDAI without Damage Score (both p < 0.05) and BPDAI Total Score (both p < 0.05). No correlation was found in other statistical analyses between hematological inflammatory markers and clinical characteristics in BP patients involved in the present study. Therefore, NLR and PLR are positively correlated with disease activity of BP.
The Expression and Prognosis for Aurora kinases in Human non-small cell lung cancer
Authors: Ji zhaodong , Wang Yue , Zhang Cuiping , Cao Xinyi , Li Yue , Guan Ming 
Published: November 2022

Abstract
Purpose
Aurora kinases, as all known members of serine/threonine kinases genes family, have been found in various types of human cancer, playing their role as potent oncogenes. Increasing evidence showes that Aurora kinases are involved in lung cancer progression. However, the expression and clinical values of 3 types of Aurora kinases are still need to be further analyzed.
Methods
The expression and prognosis data of AURKs in patients with lung cancer were used to comprehensively analyze by multiple online databases including Cancer Genome Atlas (TCGA), Oncomine, gene expression profiling interactive analysis (GEPIA), Kaplan–Meier Plotter, cBioPortal, LinkedOmics.Immunohistochemistry (IHC) were also performed to explore AURKA and AURKB expression in LUAD.
Results
According to the results, the expression levels of AURKA and AURKB were higher in lung cancer tissues than in normal, whereas the AURKC expression was lower in lung cancer compared with normal. Both the AURKA and AURKB expression were positively correlated with advanced tumor stage in LUAD .Concurrently, AURKA was also significant positive correlated with advanced stage in LUSC. Survival analysis revealed that the high expression of AURKs were associated with low overall survival (OS), progression-free survival (PFS), and post-progression survival (PPS) of all of the patients with lung cancer especially in LUAD.AURKA and AURKB expression levels significantly correlated with immune cell infiltration and immune checkpoint genes in LUAD,suggested AURKA and AURKB were potential target for improving the efficacy of immunotherapy in LUAD patients.
Conclusion
In summary, this study implied that AURKA and AURKB are valuable markers for the prognosis of non-small cell lung cancer.
Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss
Authors: Li Guangfei , Li Yashuang , Zhang Zhao , Chen Yu , Li Bao , Hao Dongmei , Yang Lin , Yang Yimin , Li Xuwen , Li Chiang-Shan Ray 
Published: November 2022

AbstractVentral striatum (VS) processes rewarding and punishing stimuli. Women and men vary in externalizing and internalizing traits, which may influence neural responses to reward and punishment. To investigate sex differences in how individual traits influence VS responses to reward and punishment, we curated the data of the Human Connectome Project and identified 981 (473 men) subjects evaluated by the Achenbach Adult Self-Report Syndrome Scales. We processed the imaging data with published routines and extracted VS reactivity (β) to win and to loss vs. baseline in a gambling task for correlation with externalizing and internalizing symptom severity. Men vs. women showed more severe externalizing symptoms and higher VS response to monetary losses (VS-loss β) but not to wins. Men but not women showed a significant, positive correlation between VS-loss β and externalizing traits, and the sex difference was confirmed by a slope test. The correlation each of VS-loss and VS-win β vs. externalizing traits and of VS-loss β each vs. internalizing and vs. externalizing traits differed significantly in slope, confirming its specificity, in men. Further, the sex-specific relationship between VS-loss β and externalizing trait did not extend to activities during exposure to negative emotion in the face matching task. To conclude, VS responses to loss but not to win and their correlation with externalizing rather than internalizing symptom severity showed sex differences in young adults. The findings highlight the relationship of externalizing traits and VS reactivity to monetary loss and may have implications for psychological models of externalizing behaviors in men.
Disrespect and Abuse during Childbirth in Public Health Facilities in Eastern Ethiopia: a cross-sectional study
Authors: Usso Ahmedin Aliyi , Adem Hassen Abdi , Alemu Addisu , Mohammed Aminu 
Published: November 2022

Abstract
Background: Even though compassionate respectful maternity care during childbirth is an important component in improving the quality of maternal health care service and its utilization, evidence shows burden and associated factors of disrespect and abuse were limited in Ethiopia.
Objective: The aim of this study was to assess disrespect and abuse during childbirth and associated factors among women gave birth in public health facilities in East Hararghe Zone, eastern Ethiopia.
Methods: A cross-sectional study was conducted among 530 women gave birth in randomly selected public health facilities in East Hararghe zone from 01 to 30 April 2020. All eligible women gave birth in the facilities were interviewed using structured questionnaire. Data entered using EpiData 3.1 and exported to SPSS version 24 for analysis. Bi-variable and multi-variable logistic regression analyses were employed to identify factors associated with disrespect and abuse during childbirth. Adjusted odds ratio (AOR) with 95% confidence interval (CI) was used to report association. A p-value less than 0.05 were used to declare as statistically significantly associated with the dependent variable.
Results: overall 77% (95% CI: 73%, 81%) of women reported at least one types of disrespect and abuse during childbirth. Women having monthly income less than 2000 Birr (AOR=2.29, 95% CI: 1.41, 3.71), living greater than 30 minute away from nearby health facilities (AOR= 2.10 95% CI: 1.30, 3.39), not attended ANC visit (AOR=4.29, 95% CI: 2.17, 8.52), and delivered during nighttime (AOR=2.16, 95% CI: 1.37, 3.41) were more likely reported disrespect and abuse during childbirth.
Conclusion: Almost four in every five women delivered in public health facilities in East Hararghe zone were disrespected and abused during childbirth. Encouraging all pregnant women to attend ANC visit and improving the quality of health care service during nighttime in all health facilities is essential for reducing disrespect and abuse.
Hepatoprotective effect of Pinostrobin against Thioacetamide-induced liver cirrhosis in rats
Authors: Jabbar Ahmed Aj. , Abdulla Mahmood A. 
Published: November 2022

Abstract

Pinostrobin was used in traditional medication for management of numerous syndromes. In the current study, histology, immunohistochemistry, and hepatoprotection effects of Pinostrobin were assessed against thioacetamide (TAA) hepatotoxicity in rats. Thirty rats were arbitrarily separated into five groups. Group 1 was intraperitoneally (i.p) injected with distilled water 3 times/week and fed (po) daily with 10% Tween 20 for 2 months. Group 2–5 were i.p. injected with 200 mg/kg TAA thrice weekly for 8 weeks and fed with 10% Tween 20, 50 mg/kg silymarin, 30 and 60 mg/kg of Pinostrobin daily for 8 weeks, respectively. Experimental groups fed groups showed that Pinostrobin significant reduction in liver index and hepatocyte proliferation with much lesser cell injury. These groups were significantly down-regulated the PCNA and α-SMA. The liver homogenate exhibited increased antioxidant enzymes (SOD and CAT) activities accompanied with decline in malondialdehyde (MDA) level. The serum level of bilirubin, total protein, albumin and liver enzymes (ALP, ALT, and AST) were restored to normal and were comparable to that normal control and silymarin with TAA treated groups. The hepatotoxic group showed a significant rise in serum liver biochemical markers together with a considerable decrease in protein and albumin level compared to the normal group. The hepatotoxic group displayed decreased catalase and superoxide dismutase activities while increased lipid peroxidation. Pinostrobin decreased level of TNF-a, IL-6 and increased the level of IL-10. Acute toxicity with a higher dose of 500 mg/kg Pinostrobin did not manifest any toxicological signs in rats. Macroscopy of hepatotoxic liver exhibited irregular, rough surface with micro and macro nodule. Histopathology stained by Hematoxylin and Eosin, and Masson Trichrome showed there was inflammation and infiltration of lymphocytes, focal necrosis, fibrosis, and bile duct propagation. Pinostrobin fed group had expressively reduced TAA toxicity in gross and histology as designated by fewer disturbances of hepatic tissue, slight fibrosis, and low-grade cells infiltration. Immunohistochemical staining designated that pinostrobin significantly down-regulated the expression of proliferation cellular nucleus antigen (PCNA) and alpha-smooth muscle actin (α-SMA) in the liver. Thus, the findings of this study presented that the hepatoprotective effect of this plant may be due to a reduction in toxicity, inhibition of hepatocytes proliferation, down-regulation of PCNA and α-SMA, decreased enzyme markersand increased protein and albumin increased endogenous enzymes and reduced lipid peroxidation level.
Tracking the damages of the Shaheen cyclone in the Sultanate of Oman
Authors: Ibrahim Osama Ragab , Al-Amir Maryam , Al-Maghawry Salma 
Published: November 2022

Abstract
The Sultanate of Oman is in the south-eastern part of the Persian Gulf. Oman's coast causes Oman to be exposed to tropical cyclones occasionally. The damages occur when hurricanes reach the land, but some hurricanes dissipate in the sea without any noticeable harm. Generally, these strong storms hit Oman every 3 or 4 years between June and October, and it is mostly in the southern part of the Sultanate. One of these cyclones was Gonu on June 1, 2007, which caused 50 deaths in total and the damaged areas cost around $4.2 billion (2007 US dollars). This paper reviews and tracks the tropical cyclone Shaheen, which hit the Omani coast on October 2, 2021. We have used the hydrological data of previous cyclones to state the level of damage the cyclone caused. As expected, the cyclone caused a lot of human and material losses in a very short period due to the inadequate flood drain systems in Al-Khaboura city. Results showed the necessity of a proper stormwater drainage system to be installed in the northern cities of Oman. These effects were followed by a 2-day holiday for both government and private sectors for the sake of people's safety.
Gastrointestinal, Liver, Pancreas, Oral and Psychological Long-term
Symptoms of COVID-19 After Recovery: A Review
Authors: Afrisham Reza , Jadidi Yasaman , Davoudi Maryam , Moayedi Kiana , Soliemanifar Omid , Eleni Xirouchaki Chrysovalantou , Ashtary-Larky Damoon , Seyyedebrahimi Shadisadat , Alizadeh Shaban 
Published: November 2022

Abstracts:
Due to the importance of control and prevention of COVID-19-correlated long-term symptoms,
the present review article has summarized what has been currently known regarding the molecular
and cellular mechanisms linking COVID-19 to important long-term complications including
psychological complications, liver and gastrointestinal manifestations, oral signs as well as even
diabetes. COVID-19 can directly affect the body cells through their Angiotensin-converting enzyme 2
(ACE-2) to induce inflammatory responses and cytokine storm. The cytokines cause the release of
reactive oxygen species (ROS) and subsequently initiate and promote cell injuries. Another way,
COVID-19-associated dysbiosis may be involved in GI pathogenesis. In addition, SARS-CoV-2
reduces butyrate-secreting bacteria and leads to the induction of hyperinflammation. Moreover,
SARS-CoV-2-mediated endoplasmic reticulum stress induces de novo lipogenesis in hepatocytes,
which leads to hepatic steatosis and inhibits autophagy via increasing mTOR. In pancreas tissue, the
virus damages beta-cells and impairs insulin secretion. SARS-COV-2 may change the ACE2 activity
by modifying ANGII levels in taste buds which leads to gustatory dysfunction. SARS-CoV-2
infection and its resulting stress can lead to severe inflammation that can subsequently alter
neurotransmitter signals. This, in turn, negatively affects the structure of neurons and leads to mood
and anxiety disorders. In conclusion, all the pathways mentioned earlier can play a crucial role in the
disease's pathogenesis and related comorbidities. However, more studies are needed to clarify the underlying
mechanism of the pathogenesis of the new coming virus.
Inflammation as Treatment Target for Status Epilepticus
Authors: Rejdak Konrad , Pikulicka Agata , Piekarska Małgorzata , Pacek Katarzyna , Płachta Kamila 
Published: November 2022

Background:
Status epilepticus (SE) is a serious neurological disease that manifests as prolonged
seizures that last more than 5 minutes and between such episodes, patients do not regain consciousness.
It can result in cognitive defects, brain damage, or even death. It is commonly known that
one of the causes can be an inflammatory process, but here we will focus on inflammation as a result
of new onset refractory status epilepticus and, related to this, new promising forms of SE treatment.
Particular emphasis has been focused on new-onset refractory status epilepticus (NORSE).

Methods:
Based on public research databases, drugs with anti-inflammatory activity – commonly used
in different spheres of medicine – have been reviewed as potentially treating status epilepticus.

Results:
There is seizable clinical research suggesting that drugs that decrease inflammatory processes
might be effective in terminating status epilepticus.

Conclusion:
There is growing evidence showing that adding anti-inflammatory drugs to basic antiepileptic
treatment enhances the efficiency of the therapeutic process, with special potential in NORSE
cases.
The Regulated Cell Death and Potential Interventions in Preterm Infants
after Intracerebral Hemorrhage
Authors: Wu Yanan , Sun Yanyan , Wang Xiaoyang , Zhu Changlian 
Published: November 2022

Abstract:
Intracerebral hemorrhage (ICH) in preterm infants is one of the major co-morbidities of preterm
birth and is associated with long-term neurodevelopmental deficits. There are currently no widely
accepted treatments to prevent ICH or therapies for the neurological sequelae. With studies broadening
the scope of cell death, the newly defined concept of regulated cell death has enriched our understanding
of the underlying mechanisms of secondary brain injury after ICH and has suggested potential interventions
in preterm infants. In this review, we will summarize the current evidence for regulated
cell death pathways in preterm infants after ICH, including apoptosis, necroptosis, pyroptosis, ferroptosis,
autophagy, and PANoptosis as well as several potential intervention strategies that may protect
the immature brain from secondary injury after ICH through regulating regulated cell death.
Acemannan from Aloe vera Extract: A Catalyst-Free, Approach for the
Access of Imidazole-Fused Nitrogen-Bridgehead Heterocycles
Authors: Baranwal Jyoti , Singh Swastika , Kushwaha Smriti , Jyoti Archana 
Published: November 2022

Abstract:
A series of 2-phenyl substituted imidazo-pyridines, pyrazines and pyrimidines were synthesized
through an efficient one-pot, environmentally benign, and regioselective strategy which involves
the reaction between 2-bromocarbonyl compounds and 2-aminopyridines, 2-aminopyrazines, 2-
aminopyrimidines, respectively using aloe vera/water (3:2) as a green promoting media. To the best of
our knowledge, this is the first aloe vera promoted protocol for the synthesis of this important scaffold
having potential applications in medicinal and materials chemistry. The use of aloe vera as a biorenewable
and biodegradable reaction medium-cum-promoter, operational simplicity, use of readily
available substrates, mild reaction conditions, broad substrate scope, short reaction time, easy workup,
and high yields, makes the disclosed protocol a superior alternative to existing methods. Substituted
imidazo-pyridines, pyrazines and pyrimidines were obtained with 95%, 76% and 84% yields, respectively.
Thermodynamics, Kinetics and Isotherms Studies for Sorption of Direct
and Disperse Dyes onto Eco-friendly Pre-treated Cellulose Acetate Fabric
using Ultraviolet Irradiation
Authors: Zolriasatein Ali Akbar 
Published: November 2022

Introduction:
Owing to the restoration of hydroxyl groups, cellulose acetate fibers can be dyed
with direct dyes. There are some drawbacks in the conventional deacetylation process of cellulose acetate
from environmental point of view.

Methods:
This process involves high temperature, alkalinity and large volume of effluent. The goal of
this work is to improve the dyeing properties of cellulose acetate fabric using an eco-friendly treatment
process. In this paper, cellulose acetate fabric was treated with ultraviolet light (UVB) at an air pressure
of 1 atm to improve dyeability. Then, the untreated and UV treated fabrics were dyed with direct and
disperse dyes. UV treated cellulose acetate fabric showed higher dye adsorption compare to that of untreated
cellulose acetate fabric. Five adsorption isotherm models including sold solution, Langmuir,
Freundlich, Temkin and BET were applied to determine the adsorption behavior. At all temperatures studied,
experimental data were better fitted with the Freundlich and Nernst models for direct and disperse
dyes respectively. Thermodynamic parameters such as change in free energy (ΔG0), the enthalpy (ΔH0),
and the entropy (ΔS0) were also evaluated.

Results:
The calculated thermodynamic values showed that the adsorption of these dyes onto the cellulose
acetate fabric was a physical adsorption process and endothermic in nature. These data also implied that
the adsorption of direct dye onto cellulose acetate fabric was spontaneous at the experimental temperature
range and adsorption of disperse dyes can be spontaneous at higher temperatures. Moreover, the ΔG0
values for the adsorption of disperse dyes onto the UV-treated fabrics were less than those for untreated
fabrics suggesting that UV treated fabrics require less external energy.

Conclusion:
Among the kinetic models studied, it was found that the pseudo second-order kinetic model
was the best model to describe the dye sorption process on the UV treated and untreated cellulose acetate
fabrics. The UV treatment led to an improvement in the boundary layer diffusion effect.