bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pretherapeutic functional connectivity of tractography-based targeting of the ventral intermediate nucleus for predicting tremor response in patients with Parkinson’s disease after thalamotomy with MRI-guided focused ultrasound
Authors: Xiong Yongqin , Lin Jiaji , Pan Longsheng , Zong Rui , Bian Xiangbing , Duan Caohui , Zhang Dekang , Lou Xin 
Published: March 2022

OBJECTIVE
Tractography-based direct targeting of the ventral intermediate nucleus (T-VIM) is a novel method that provides patient-specific VIM coordinates. This study aimed to explore the accuracy and predictive value of using T-VIM in combination with tractography and resting-state functional connectivity techniques to perform magnetic resonance imaging–guided focused ultrasound (MRgFUS) thalamotomy as a treatment of Parkinson’s disease (PD).

METHODS
PD patients underwent MRgFUS thalamotomy and were recruited for functional MRI scanning. A subscore of the Clinical Rating Scale for Tremor was used to evaluate tremor improvement. T-VIM and surgical VIM (S-VIM) were defined on preoperative diffusion tensor MRI and 24-hour postoperative T1-weighted imaging, respectively. The overlapping volume and center distance between S-VIM and T-VIM were measured to determine their correlations with 12-month postoperative tremor improvement. Moreover, pretherapeutic functional connectivity of T-VIM or S-VIM, based on region-of-interest connectivity and whole-brain seed-to-voxel connectivity, was measured with the resting-state functional connectivity technique to investigate their correlations with tremor improvement.

RESULTS
All patients had excellent tremor improvement (mean [range] tremor improvement 74.82% [50.00%–94.44%]). The authors found that both overlapping volume and center distance between T-VIM and S-VIM were significantly correlated with tremor improvement (r = 0.788 and p = 0.012 for overlapping volume; r = −0.696 and p = 0.037 for center distance). Pretherapeutic functional connectivity of T-VIM with the ipsilateral sensorimotor cortex (r = 0.876 and p = 0.002), subthalamic nucleus (r = 0.700 and p = 0.036), and visual area (r = 0.911 and p = 0.001) was significantly and positively correlated with tremor improvement.

CONCLUSIONS
T-VIM may improve the clinical application of MRgFUS thalamotomy as a treatment of PD. Pretherapeutic functional connectivity of T-VIM with the ipsilateral sensorimotor cortex, subthalamic nucleus, and visual area may predict PD tremor responses after MRgFUS thalamotomy.
Outcomes of Gamma Knife radiosurgery for skull base chondrosarcomas: a multi-institutional retrospective study
Authors: Kawashima Mariko , Shin Masahiro , Jokura Hidefumi , Hasegawa Toshinori , Yamanaka Kazuhiro , Yamamoto Masaaki , Matsunaga Shigeo , Akabane Atsuya , Yomo Shoji , Onoue Shinji , Kondoh Takeshi , Hasegawa Hirotaka , Shinya Yuki , Saito Nobuhito 
Published: March 2022

OBJECTIVE
Radiotherapy has an essential role in the management of skull base chondrosarcomas (SBCs) after resection. This multi-institutional study evaluated the outcomes of Gamma Knife radiosurgery (GKRS) for histopathologically proven SBCs.

METHODS
Data of patients who underwent GKRS for SBCs at Gamma Knife centers in Japan were retrospectively collected. Patients without a histopathological diagnosis and those who had intracranial metastases from extracranial chondrosarcomas were excluded. Histologically, grade III and some nonconventional variants were identified as aggressive types. The cumulative local control rates (LCRs) and disease-specific survival (DSS) rates were calculated using the Kaplan-Meier method. Factors potentially affecting the LCR were evaluated using the Cox proportional hazards model for bivariate and multivariate analyses. The incidence of radiation-induced adverse effects (RAEs) was calculated as crude rates, and factors associated with RAEs were examined using Fisher’s exact test.

RESULTS
Fifty-one patients were enrolled, with a median age of 38 years. Thirty patients (59%) were treated with upfront GKRS for residual SBCs after resection (n = 27) or biopsy (n = 3), and 21 (41%) underwent GKRS as a salvage treatment for recurrence. The median tumor volume was 8 cm3. The overall LCRs were 87% at 3 years, 78% at 5 years, and 67% at 10 years after GKRS. A better LCR was associated with a higher prescription dose (p = 0.039) and no history of repeated recurrence before GKRS (p = 0.024). The LCRs among patients with the nonaggressive histological type and treatment with ≥ 16 Gy were 88% at 3 years, 83% at 5 years, and 83% at 10 years. The overall survival rates after GKRS were 96% at 5 years and 83% at 10 years. Although RAEs were observed in 3 patients (6%), no severe RAEs with Common Terminology Criteria for Adverse Events grade 3 or higher were identified. No significant factor was associated with RAEs.

CONCLUSIONS
GKRS for SBCs has a favorably low risk of RAEs and could be a reasonable therapeutic option for SBC in multimodality management. A sufﬁcient GKRS prescription dose is necessary for higher LCRs. Histological grading and subtype evaluations are important for excluding exceptional SBCs. Patients with conventional SBCs have a long life expectancy and should be observed for life after treatment.
Innovative ways to control dust and explosion safety of mine workings
Authors: Romanchenko Sergey , Naganovskiy Yuri , Kornev Anton 
Published: March 2022

Ensuring dust and explosion safety during underground coal mining is one of the most important tasks of industrial safety and labor protection departments. The main method of preventing explosions of coal dust settled in mine workings is to process them with stone dust (rock dusting). The traditional methods of quality control of rock dusting include radioisotope, optical and chemical methods. To implement them, the devices are equipped with environmentally harmful radioactive elements, expensive optical sensors, desiccants and replaceable flasks with chemical reagents, which increases the cost of analysis and its duration. The measurement error of these devices is 10 % or more. The main purpose of the study is to develop and substantiate a new method for monitoring the dust and explosion safety of mine workings, which will be devoid of the disadvantages of the methods mentioned above. It is proposed to evaluate the quality of rock-dust distribution by a fundamentally new way – thermogravimetric. The method was tested on the dust of coal mines in Kuzbass and the Vorkuta basin, including dust samples taken in mines with actual explosions. The article presents the results of experimental studies of the processes of thermal destruction of coal and stone dust mixtures. The non-overlapping intervals of the thermogravimetric reaction are identified: moisture yield (35-132 °С); volatile matter yield from coal (380-580 °С); thermal degradation of limestone with carbon dioxide yield (650-850 °С). Methods and mathematical dependencies for processing significant and qualitative identification characteristics of thermogravimetric curves in determining the content of non-combustible components in a sample of mine dust are considered.
Methodology for testing pipeline steels for resistance to grooving corrosion
Authors: Bolobov Viktor , Popov Grigoriy 
Published: March 2022

The methodology for testing pipeline steels is suggested on the assumption that for the destruction of pipes in field oil pipelines by the mechanism of grooving corrosion the simultaneous fulfillment of such conditions as the occurrence of scratches on the lower generatrix of the pipe, eventually growing into a channel in the form of a groove, emulsion enrichment with oxygen, presence of pipe wall metal in a stressed state, presence of chlorine-ion in the oil-water emulsion is required. Tests are suggested to be carried out in 3 % aqueous solution of NaCl with continuous aeration by air on bent plates 150×15×3 mm, made of the analyzed steel, the middle part of which is under the action of residual stresses σres, close to the level of maximum equivalent stresses σeqv in the wall of the oil pipeline, with the presence of a cut on this part on the inner side of the plate as an initiator of additional mechanical stresses. Using the value of the modulus of normal elasticity of the analyzed steel, the degree of residual strain of the elastic-plastic body from this material, corresponding to the value σres ≈ σeqv is calculated, based on which the plates are bent to the required deflection angle, after which the cut is applied to them. After keeping the plates in the corrosive medium for each of them the increase in depth of the cut as a result of corrosion of the walls by the corrosive medium is analyzed, from which the rate of steel K by the mechanism of grooving corrosion is calculated taking into account the duration of tests. Corrosion rate values for two pipe steel grades determined by the suggested procedure are given. The comparison of K values obtained leads to the conclusion about the higher resistance to grooving corrosion of 09G2S steel.
Intracerebral Infection with E. coli Impairs Spatial Learning and Induces Necrosis of Hippocampal Neurons in the Tg2576 Mouse Model of Alzheimer’s Disease
Authors: Schütze Sandra , Döpke Anika , Kellert Benedikt , Seele Jana , Ballüer Melissa , Bunkowski Stephanie , Kreutzfeldt Mario , Brück Wolfgang , Nau Roland 
Published: March 2022

Background: In patients with Alzheimer’s disease (AD), bacterial infections are often associated with a cognitive decline. Animal models of genuine acute infections with viable bacteria which induce deterioration of neurodegenerative diseases are missing. Objective: We assessed the effect of an intracerebral infection with E. coli in a mouse model of AD. Methods: 13-month-old Tg2576 +/- mice and transgene negative littermates (Tg2576 -/-) received an intracerebral injection with E. coli K1 or saline followed by treatment with ceftriaxone starting 41 h post infection (p.i.) for 5 days. For 4 weeks, mice were monitored for clinical status, weight, motor functions, and neuropsychological status using the Morris water maze. ELISAs, stainings, and immunohistochemistry in brains were performed at the end of the experiment. Results: Mortality of the infection was approximately 20%. After 4 weeks, spatial learning of infected Tg2576 +/- mice was compromised compared to non-infected Tg2576 +/- mice ( p < 0.05). E. coli infection did not influence spatial learning in Tg2576 -/- mice, or spatial memory in both Tg2576 +/- and -/- mice within 4 weeks p.i.. Necrosis of hippocampal neurons was induced in infected compared to non-infected Tg2576 +/- mice 4 weeks p.i., whereas brain concentrations of Aβ1–40, Aβ1–42, and phosphoTau as well as axonal damage and microglia density were not altered. Conclusion: Here, we proved in principle that a genuine acute bacterial infection can worsen cognitive functions of AD mice. Mouse models of subacute systemic infections are needed to develop new strategies for the treatment of bacterial infections in patients with AD in order to minimize their cognitive decline.
Effect of casein phosphopeptide amorphous calcium fluoride phosphate and calcium glycerophosphate on incisors with molar-incisor hypomineralization: A cross-over, randomized clinical trial
Authors: Sezer Berkant , Tuğcu Nihan , Calışkan Cansu , Durmuş Başak , Kupets Tatiana , Bekiroğlu Nural , Kargül Betül , Bourgeois Denis 
Published: March 2022

BACKGROUND: Within the scope of minimally invasive dentistry, the use of different biocompatible remineralization agents on incisors affected by molar-incisor hypomineralization (MIH) gains importance. OBJECTIVE: To evaluate the effect of casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP) and calcium glycerophosphate (CaGP) in mineral density (MD) of white/creamy and yellow/brown demarcated opacities on incisors affected by MIH by means laser fluorescence (LF). METHODS: As a cross-over, randomized trial, twenty-two children with 167 incisors affected by MIH were recruited and randomly assigned to one of the two different agents and crossed over to other agents with two weeks washout in between. Incisors were examined by using LF at all before and after three months periods. RESULTS: The results of the paired t-tests for determining the period effect between the baseline findings showed significant difference in white/creamy and yellow/brown demarcated opacities of LF values for both groups (p < 0.05). The difference between both groups according to after categorization of 20% increasing in MD in the percent of change before and after application on LF values; was not found statistically significant in white/creamy (p = 0.970) and yellow/brown (p = 0.948) opacities. CONCLUSIONS: The primary outcome was CPP-ACFP and CaGP had a positive effect in decreasing hypomineralization on MIH-affected enamel for three months period.
Development of Saraiki WordNet by Mapping of Word Senses: A Corpus-based Approach
Authors: Gul Sarah , Azher Musarrat , Nawaz Sana 
Published: March 2022

This paper aimed to develop the Saraiki WordNet. Saraiki is one of the regional languages spoken in Pakistan and has a unique history of its own. Saraiki language is remarkably similar to two languages, namely Punjabi and Sindhi. Saraiki has different dialects and each dialect is representative of the region where it is spoken. This paper used the Urdu WordNet (Zafar, Mahmood, Shams & Hussain, 2014) as the basis for the formation of Saraiki WordNet. Urdu WordNet (Zafar et al., 2014) was created by UET Lahore and is based on Princeton WordNet (Miller, 1990). Dictionaries or lughats and literary sources, such as poetry, fiction, as well as non-literary sources, such as newspapers of Saraiki language, were used to extract data. Additionally, Urdu word senses were mapped onto Saraiki word senses. The method used in this study was mapping, while the expansion approach was used in the mapping process. This study may aid in creating bilingual dictionaries (of Saraiki and Urdu?) in the future.
Keywords: expand approach, mapping, Saraiki language, WordNet
Calidad del sueño en el personal administrativo de la Fundación Universitaria del Área Andina
Authors: Cadavid Vanegas Daniela , Arboleda Amórtegui Gleydiz , Bernal Ortiz Valentina 
Published: March 2022

La calidad del sueño no se refiere únicamente al hecho de dormir bien durante la noche, sino que también incluye un buen funcionamiento diurno, es decir, la atención necesaria durante el día para realizar cualquier tipo de actividad, por lo que es necesario resaltar que la persona promedio debe dormir, al menos, entre siete u ocho horas diarias para tener una debida higiene del sueño. Se hallaron antecedentes de diferentes investigaciones que dan cuenta de los trastornos generados por la falta o la mala calidad del sueño (Campos Burga, 2018). Un estudio realizado en Arabia Saudita, en el 2008, prueba que las asociaciones entre el estrés, la falta de sueño y la somnolencia diurna excesiva. En Brasil, la Universidad Federal reportó en el 2015 la asociación entre trastorno temporomandibular y la ansiedad, la calidad del sueño y la calidad de vida en los profesionales de enfermería. Igualmente, en el 2014, en Ecuador un estudio estableció que tener buena calidad del sueño es un factor protector frente a la depresión. Además, en Colombia una investigación que examinó la calidad de vida de estudiantes de posgrado de medicina evidenció que el 40 % de estos sufren patologías relacionadas con la gran cantidad de trabajo y el estrés emocional. A su vez, la Universidad Nacional de Colombia, en el 2014, evidenció que los trastornos del sueño están relacionados con el trabajo por turnos nocturnos y forman parte de los trastornos del ritmo circadiano, mientras la Universidad del Rosario, en el 2014, encontró que la falta de sueño por turnos de noche tuvo una respuesta negativa (Godnho et al., 2018).
Enhancing Capacity and Stability of Anionic MOFs as Electrode Material by Cation Exchange
Authors: Akintola Oluseun , Gerlach Patrick , Plass Christian T. , Balducci Andrea , Plass Winfried 
Published: March 2022

In this study we report on the characterization and use of the anionic metal-organic framework (MOF) JUMP-1, [(Me2NH2)2[Co3(ntb)2(bdc)]]n, alongside with its alkali-metal ion-exchanged analogs JUMP-1(Li) and JUMP-1(Na), as electrode materials for lithium and sodium batteries. Composite electrodes containing these anionic-MOFs were prepared and tested in 1 M lithium bis(trifluoromethylsulfonyl)imide (LiTFSI) in propylene carbonate (PC) and/or 1 M sodium TFSI (NaTFSI) in PC. We showed that the ion-exchanged materials JUMP-1(Li) and JUMP-1(Na) display higher capacities in comparison with the original as-prepared compound JUMP-1 (490 mA∙h∙g−1 vs. 164 mA∙h∙g−1 and 83 mA∙h∙g−1 vs. 73 mA∙h∙g−1 in Li and Na based electrolytes, respectively). Additionally, we showed that the stability of the electrodes containing the ion-exchanged materials is higher than that of JUMP-1, suggesting a form of chemical pre-alkalation works to stabilize them prior to cycling. The results of these studies indicate that the use of designed anionic-MOFs represents a promising strategy for the realization of high performance electrodes suitable for energy storage devices.
A Risk Stratification Scheme for In-Hospital Cardiogenic Shock in Patients With Acute Myocardial Infarction
Authors: Yang Jun-qing , Ran Peng , Li Jie , Zhong Qi , Smith Sidney C. , Wang Yan , Fonarow Gregg C. , Qiu Jia , Morgan Louise , Wei Xue-biao , Chen Xiao-bo , Huang Jie-leng , Hao Yong-chen , Zhou Ying-ling , Siu Chung-Wah , Zhao Dong , Chen Ji-yan , Yu Dan-qing 
Published: March 2022

ObjectiveCardiogenic shock (CS) is the leading cause of death in patients with acute myocardial infarction (AMI) despite advances in care. This study aims to derive and validate a risk score for in-hospital development of CS in patients with AMI.MethodsIn this study, we used the Improving Care for Cardiovascular Disease in China–Acute Coronary Syndrome (CCC–ACS) registry of 76,807 patients for model development and internal validation. These patients came from 158 tertiary hospitals and 82 secondary hospitals between 2014 and 2019, presenting AMI without CS upon admission. The eligible patients with AMI were randomly assigned to derivation (n = 53,790) and internal validation (n = 23,017) cohorts. Another cohort of 2,205 patients with AMI between 2014 and 2016 was used for external validation. Based on the identified predictors for in-hospital CS, a new point-based CS risk scheme, referred to as the CCC–ACS CS score, was developed and validated.ResultsA total of 866 (1.1%) and 39 (1.8%) patients subsequently developed in-hospital CS in the CCC–ACS project and external validation cohort, respectively. The CCC–ACS CS score consists of seven variables, including age, acute heart failure upon admission, systolic blood pressure upon admission, heart rate, initial serum creatine kinase-MB level, estimated glomerular filtration rate, and mechanical complications. The area under the curve for in-hospital development of CS was 0.73, 0.71, and 0.85 in the derivation, internal validation and external validation cohorts, respectively.ConclusionThis newly developed CCC–ACS CS score can quantify the risk of in-hospital CS for patients with AMI, which may help in clinical decision making.Clinical Trial Registrationwww.ClinicalTrials.gov, identifier: NCT02306616.
A Case Series of Myocarditis Following Third (Booster) Dose of COVID-19 Vaccination: Magnetic Resonance Imaging Study
Authors: Shiyovich Arthur , Witberg Guy , Aviv Yaron , Kornowski Ran , Hamdan Ashraf 
Published: March 2022

BackgroundMyocarditis has been reported following the first two doses of Pfizer-BNT162b2 messenger RNA (mRNA) COVID-19 vaccination. Administration of a third dose (booster) of the vaccine was initiated recently in Israel.ObjectiveThe aim of this study was to describe the characteristics of patients referred for cardiac magnetic resonance (CMR) imaging with myocarditis following the booster.MethodsPatients referred for CMR imaging with a clinical diagnosis of myocarditis within 21 days following the booster, between July 13 and November 11, 2021, were analyzed.ResultsOverall, 4 patients were included, 3/4 (75%) were men, and the mean age was 27 ± 10 years. The time from booster administration to the onset of symptoms was 5.75 ± 4.8 days (range 2–14). Obstructive coronary artery disease was excluded in 3 of the patients (75%). CMR was performed 34 ± 15 days (range 8-47 days) following the 3rd vaccination. The mean left ventricular ejection fraction was 61 ± 7% (range 53–71%), and regional wall motion abnormalities were present in one of the patients. Global T1 was increased in one of the patients, while focal T1 values were increased in 3 of the patients. Global T2 was increased in one of the patients, while focal T2 values were increased in all the patients. Global ECV was increased in 3 of the patients, while focal ECV was increased in all the patients. Median late gadolinium enhancement (LGE) was 4 ± 3% (range 1–9%), with the inferolateral segment as the most common location (3 of the 4 patients). All the patients met the Updated Lake Louise Criteria.ConclusionsPatient characteristics and CMR imaging findings of myocarditis following the administration of the booster vaccine are relatively mild and consistent with those observed with the first two doses. Although larger-scale prospective studies are necessary, these initial findings are somewhat reassuring.
Factors Controlling the Spatial Distribution of Dissolved Organic Matter With Changes in the C/N Ratio From the Upper to Lower Reaches of the Ishikari River, Japan
Authors: Takaki Yuji , Hattori Keisuke , Yamashita Youhei 
Published: March 2022

Dissolved organic matter (DOM), particularly dissolved organic nitrogen (DON), is an important source of energy and/or organic nutrients for heterotrophic microorganisms in rivers. Although various factors controlling the quantity and quality of stream and riverine DOM have been extensively studied, DON has been under-researched compared to dissolved organic carbon (DOC). The spatial distribution of DOC and DON concentrations with respect to the C/N ratio and DOM optical properties was investigated in the Ishikari River and its tributaries in Hokkaido, northern Japan. Here, the upper reaches are forested and the middle and lower reaches are encompassed by agricultural land, in particular paddy fields. Furthermore, dark incubation experiments were conducted using filtered riverine water (&lt;0.7 µm) to determine the bioavailability of DOC and DON (particularly due to small microorganisms) considered as a factor controlling the spatial distribution. In the mainstream, DOC and DON concentrations increased with river flow in the upper and middle reaches and remained unchanged in the lower reaches. The C/N ratio of bulk DOM decreased continuously from the upper reaches to lower reaches. The optical properties exhibited changes in the DOM characteristics in terms of higher molecular weight and higher aromaticity from the upper to middle reaches, suggesting that flooded paddy fields largely altered the riverine DOM concentration and composition. In the lower reaches, the C/N ratio of the bulk DOM decreased with the river flow. However, according to principal component analysis, no changes were observed in the optical properties with river flow, suggesting that the C/N ratio of bulk DOM changed owing to in situ biological activity in the river. DOC biodegradation was observed at four sites in the upper and middle reaches but not at the two sites in the lower reaches. However, the DON concentration during the dark incubation experiments at all sites did not differ significantly, which implies that microbial degradation, particularly by small microorganisms, is a factor that decreased the C/N ratio of bulk DOM in the upper and middle reaches. In contrast, large microorganisms possibly degraded C-rich DOM to decrease the C/N ratio of bulk DOM in the lower reaches of the Ishikari River.