bluuebunny/crossref_metadata_2025_split huggingface dataset:
IDENTIFIKASI KERJASAMA PENGENDALIAN PEMANFAATAN RUANG DENGAN POLA PARTISIPATIF DI KOTA PAMANUKAN KABUPATEN SUBANG
Authors: NGURAH PURNAMA JAYA GDE 
Published: July 2022

Identifikasi Kerjasama Pengendalian Pemanfaatan Ruang dengan Pola Partisipatif di Kota Pamanukan Kabupaten Subang. Ada dua hal yang perlu mendapat perhatian utama dalam konsteks penataan ruang, yaitu hak kepemilikan atas sebidang tanah, maka kepada yang bersangkutan harus mendapat perlindungan hukum untuk memanfaatkannya. Namun persoalan timbul manakala :Kebutuhan untuk memanfaatkan sebidang tanah untuk kepentingan pribadi ternyata berbeda dengan apa yang ditetapkan dalam RTRW (Rencana Tata Ruang Wilayah).Hak untuk memanfaatkan sebidang tanah yang sudah sah dimilikinya ternyata “hilang” atau tereduksi karena tanah tersebut menurut RTRW ditetapkan untuk kepentingan umum (misalnya untuk fasos-fasum, jalan dan sebagainya).Sekelompok bidang tanah yang di tempatinya (baik telah mempunyai status kepemilikan yang jelas atau tidak) ternyata diminati oleh investor untuk di bangun dan dirubah pemanfaatannya sesuai dengan RTRW.Pada Kasus diatas menunjukan bahwa di Kabupaten Subang belum ada fungsi mediasi, advokasi dan evaluasi yang baik, sehingga persoalan tersebut timbul. Berbagai institusi yang ada nampaknya kurang efektif dalam menanggapinya, selain pihak DPRD-nya.Dari hasil rumusan kesepakatan tentang program pengembangan kawasan lindung dan budidaya selanjutnya diinformasikan kepada seluruh instansi/lembaga terkait khususnya lembaga yang bertanggungjawab dan berwenang dalam pemberian ijin pemanfaatan ruang.Untuk itu perlu dilakukan :Identifikasi instansi yang memberikan rekomendasi pemanfaatan ruang;Identifikasi sistem perijinan pemanfaatan ruang;Menyiapkan rumusan pengaturan koordinasi dan keterpaduan pemberian rekomendasi dan ijin pemanfaatan ruang.Dalam kegiatan pemberian rekomendasi ini instansi daerah (kabupaten dan propinsi) wajib melakukan koordinasi dengan TKPRD. Selanjutnya kepala daerah/bupati menerapkan standar perijinan pemanfaatan ruang.Tugas pokok dan fungsi Dinas Penataan Ruang agar disesuaikan dengan semangat upaya pemanfaatan dan pengendalian pemanfaatan ruang yang konsisten.Sistem partisipasi masyarakat secara luas dan menyeluruh dari komponen partisipan pembangunan di Kabupaten Subang. Untuk membangun sistem dan pola partisipasi yang konstruktif diperlukan dana yang cukupDisarankan, materi hasil studi ini agar ditindaklanjuti dengan penyusunan Peraturan Daerah tentang “Pengendalian Pemanfaatan Ruang Kabupaten Subang”. Kata Kunci : Tata Ruang, Pengendlian, Pemanfaatan Ruang, Pola Partisipasi
KAJIAN PENGARUH MEDIA PENAMBAT PADA REAKTOR BIOGAS FLUIDIZED BED
Authors: Kamal Netty 
Published: July 2022

Untuk mengurangi banyaknya sampah yang masuk ke TPA yaitu dengan melakukan pengolahan sampah organik menjadi biogas. Alternatif dari Pengolahan sampah organik adalah digester anaerobik. Selain dapat mengurangi jumlah sampah, pengolahan sampah organik dengan digester anaerobik dapat menghasilkan bahan bakar terbarukan. Pada penelitian ini sampah organik diambil dari beberapa tempat di sekitar kampus. Tujuan penelitian ini untuk mengolah sampah menggunakan reaktor Fluidized Bed menggunakan media batu apung. Perolehan gas dibandingkan dengan hasil bila menggunakan media lain. Parameter yang diukur adalah pH, temperatur, kandungan biogas menggunakan analisis orsat dan COD. Hasil dari penelitian ini adalah reaktor 1 yang menggunakan media batu apung, mempunyai kinerja yang paling baik dibandingkan dengan 2 media lainnya. Hal ini berdasarkan hasil dari volume perolehan biogas, analisa penurunan COD, organic loading rate, dan performa reaktor. Reaktor Fluidized Bed memiliki hasil perolehan biogas paling banyak dengan rata-rata perolehan biogas 0,093 L Biogas / L Reaktor.Hari pada reaktor 1 (Batu Apung), 0,079 L Biogas / L Reaktor.Hari, reaktor 2 (Ijuk), dan 0,089 , reaktor 3 (Sedotan) jika dibandingkan dengan reaktor Continuous Stirred Tank Reactor (CSTR) dengan volume 0,072 L Biogas / L Reaktor.Hari dan Reaktor Fixed Bed dengan volume 0,057 L Biogas / L Reaktor.Hari. Kata Kunci : reaktor, Continuous ; Stirred; Tank Reacto;r (CSTR); Fluidized’ Bed
SENSOR ROUTER OPTIK UNTUK JARINGAN FIBER OPTIK BERBASIS LIQUID CRYSTAL CELL
Authors: YAMATO YAMATO 
Published: July 2022

Sensor jaringan Fiber Optik saat ini berkembang pesat. Jaringan Fiber Optik banyak digunakan karena sifat dasar Fiber Optik yang tahan terhadap gangguan elektromagnetik dan aman terhadap terhadap atmosfer, selain itu mempunyai bobot yang ringan dan bandwidth yg lebar sebagai media transmisi. Dalam tulisan ini, diusulkan sebuah router optik yang semuanya berbasis Liquid Crystals, Polarisasi, dan Polarisasi ruang pada Beam Splitter. Implementasi dari perangkat ini dirancang untuk dapat beroperasi dengan cahaya dan telah diuji dengan Plastic Optical Fiber. Perangkat ini memiliki Crosstalk sebesar 14 dB antara saluran ON dan saluran OFF dan memiliki loss sebesar 11 dB. Waktu rata-rata saat switch yang terukur 100 ms. Perangkat ini juga dapat memeriksa Power Level Optic pada masing-masing saluran, apabila terjadi kegagalan dan alarm aktif maka secara otomatis ter-switch ke saluran operasi. Kata Kunci : Router Optik, Liquid Crystal Cell, Spliiter, Power Level Optic
APLIKASI SISTEM INFORMASI GEOGRAFIS UNTUK ANALISIS PERSEBARAN PENGGUNAAN LAHAN DI KOTA MALANG, JAWA TIMUR
Authors: RINA MUTHIA HARAHAP DESSY APRIYANTI dan 
Published: July 2022

Tanah adalah sumber utama kesejahteraan dan kehidupan masyarakat, oleh karena itu penggunaan lahan dan pemanfaatan lahan secara optimal. Pada Pasal 19 UUPA ayat 1 dijelaskan bahwa “Untuk menjamin kepastian hukum oleh pemerintah diadakan pendaftaran tanah di seluruh wilayah Republik Indonesia menurut ketentuan-ketentuan yang diatur degan Peraturan Pemerintah“, Selanjutnya pada ayat (2) nya memberikan rincian bahwa pendaftaran tanah yang disebut pada ayat (1) tersebut meliputi:Pemetaan, dan pembukuan tanahPendaftaran hak-hak atas tanah dan peralihan hak-hak tersebutPemberian surat tanda bukti hak yang berlaku sebagai alat bukti yang kuatJadi jelaslah sebenarnya bahwa tujuan pendaftaran tanah untuk memberikan kepastian hukum dan perlindungan hukum terhadap hak atas tanah. Pendaftaran Tanah adalah tugas dan beban pemerintah akan tetapi untuk mensukseskannya/keberhasilannya sangat tergantung pada partisipasi aktif / peranan masyarakat terutama pemegang hak. Perwujudan penggunaan dan pemanfaatan optimal lahan dapat dilakukan melalui penyusunan rencana tata ruang yang mengintegrasikan prinsip-prinsip pembangunan berkelanjutan. Harmonisasi dengan rencana penggunaan lahan harus diatur dalam perencanaan tata ruang sehingga setiap area tanah dapat memberikan manfaat yang optimal dan berkelanjutan dan dibudidayakan secara efisien dan seimbang sambil menghormati hak-hak masyarakat, itu akan cepat dipersiapkan dan diatur ketika tersedia penggunaan lahan peta dan penggunaan lahan skala besar. Dalam Pasal 40 Peraturan Badan Pertanahan Nasional No. 4 tahun 2006 yang mengatur tugas dan Potensi Sub Bagian Tematik Tanah di Kantor Pertanahan sedang menyiapkan survei, pemetaan, pemeliharaan dan pengembangan pemetaan tematik, survei potensi tanah, pemeliharaan teknis petugas peralatan dan pembinaan penaksir tanah terkomputerisasi. Bagian Pemetaan Tematis menyediakan Peta Tematik, di sisi lain pengukuran dan bagian survei menyediakan Peta Pendaftaran Tanah. Peta kedua menggambarkan hasil sejauh ini belum dibagikan di jajaran Kantor Pertanahan untuk masing-masing komponen dalam pembuatan dan memiliki sistem koordinat peta dan skala yang berbeda, sehingga informasi yang diberikan sebagai hasil data masih sebagian dimiliki oleh Kantor Pertanahan tidak dapat memberikan informasi dan hasil maksimal, dan biaya pemetaan menjadi sangat besar. Penelitian ini dilakukan untuk mendapatkan hasil yang akurat dan peta yang menyeluruh tentang pembagian bidang tanah lengkap dengan penggunaan lahan terutama di Kedungkandang, Kota Malang. Kata Kunci : penggunaan lahan; peta tematik; sistem informasi geografis; pertanahan
PENETAPAN ZONASI MENARA TELEKOMUNIKASI SECARA SPASIAL UNTUK PENGENDALIAN DAN PENGAWASAN DI KOTA BOGOR
Authors: Dan MUHAMAD MAHFUDZ WARYANI 
Published: July 2022

Perkembangan teknologi informasi dan komunikasi mengalami perkembangan yang sangat pesat, hal ini juga berpengaruh pada layanan yang diberikan oleh operator dalam rangka menunjang kecepatan perkembangan teknologi informasi dan komunikasi. Teknologi informasi dan komunikasi tidak bisa dipisahkan dengan adanya antena BTS (base transciever station) yang menjadi masalah, pembangunan infrastruktur menara telekomunikasi yang terlalu banyak tanpa perencanaan akan menimbulkan permasalahan yang tidak baik bagi tata ruang dan keindahan Kota Bogor. Dalam menentukan zonasi, di perlukan data dari semua menara telekomunikasi yang berdiri di Kota Bogor, selanjutnya di analisis dengan menggunakan metode AHP (Analytical Hierarchy Process). Agar lebih memudahkan untuk pemetaan menara telekomunikasi maka dikombinasikan dengan GIS (Geografik information system) dengan harapan bisa menjadi rekomendasi untuk pengambilan keputusan pemerintah Kota Bogor. Dalam menentukan zonasi tersebut yaitu dengan memperhitungkan jarak menaradan data dari titik koordinat menara tersebut berdiri. Penentuann zonasi dengan range masimg-masong 5 km, sehingga di dapatkan 4 zonasi, yaitu zona-1 pada jarak 5 km untuk wilayah kecamatan Kota Bogor Tengah, zona 2 pada jarak 5,1 km -10 km untuk wilayah kota Bogor Barat, Timur dan Utara, Zona-3 pada jarak 10,1-15 km untuk wilayah Kota Bogor Selatan dan Tanah Sareal dan Zona-4 pada jarak diatas 15,1 km untuk sebagian wilayah kota Bogor Selatan dan Tanah. Sareal. Kata kunci : SIG, ahp, zonasi, menara telekomunikasi
Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay
Authors: Carlo Audrey , Yan Qiuting , Ten Cate Hugo , De Laat-Kremers Romy , De Laat Bas , Ninivaggi Marisa 
Published: July 2022

BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis. As thrombin is the central enzyme in the coagulation pathway, it is desirable to measure thrombin generation (TG) in order to detect possible bleeding or thrombotic phenotypes, as well as to investigate the capacity of drugs affecting the formation of thrombin. By investigating the underlying processes of TG (i.e., prothrombin conversion and inactivation), additional information is collected about the dynamics of thrombin formation.ObjectivesTo obtain reference values for thrombin dynamics (TD) analysis in 112 healthy donors using an automated system for TG.MethodsTG was measured on the ST Genesia, fibrinogen on the Start, anti-thrombin (AT) on the STA R Max and α2Macroglobulin (α2M) with an in-house chromogenic assay.ResultsTG was measured using STG-BleedScreen, STG-ThromboScreen and STG-DrugScreen. The TG data was used as an input for TD analysis, in combination with plasma levels of AT, α2M and fibrinogen that were 113% (108–118%), 2.6 μM (2.2 μM−3.1 μM) and 2.9 g/L (2.6–3.2 g/L), respectively. The maximum rate of the prothrombinase complex (PCmax) and the total amount of prothrombin converted (PCtot) increased with increasing tissue factor (TF) concentration. PCtot increased from 902 to 988 nM, whereas PCmax increased from 172 to 508 nM/min. Thrombin (T)-AT and T-α2M complexes also increased with increasing TF concentration (i.e., from 860 to 955 nM and from 28 to 33 nm, respectively). PCtot, T-AT and T-α2M complex formation were strongly inhibited by addition of thrombomodulin (−44%, −43%, and −48%, respectively), whereas PCmax was affected less (−24%). PCtot, PCmax, T-AT, and T-α2M were higher in women using oral contraceptives (OC) compared to men/women without OC, and inhibition by thrombomodulin was also significantly less in women on OC (p &lt; 0.05).ConclusionsTG measured on the ST Genesia can be used as an input for TD analysis. The data obtained can be used as reference values for future clinical studies as the balance between prothrombin conversion and thrombin inactivation has shown to be useful in several clinical settings.
Early dynamic behavior of lactate in predicting continuous renal replacement therapy after surgery for acute type A aortic dissection
Authors: Wang Zhigang , Xu Jingfang , Kang Yubei , Liu Ling , Zhang Lifang , Wang Dongjin 
Published: July 2022

BackgroundIt has been well known that hyperlactatemia is an independent risk factor for postoperative mortality in patients who received acute type A aortic dissection (ATAAD) surgery. Some patients may require the assistance of continuous renal replacement therapy (CRRT) for acute postoperative renal deficiency and often associate with increased mortality rate. This study aimed to examine the association between the early dynamic change of lactate levels and postoperative CRRT in ATAAD patients who received surgical repairment.MethodsThis retrospective study included 503 patients who received ATAAD surgeries. Serum lactate levels were measured before operation and at 0, 1, 3, 6, 12, 24 h post intensive care unit (ICU) admission. We examined the association between dynamic changes of lactate and CRRT.ResultsAmong all patients, 19.9% (100 patients) required CRRT. Our data showed that the lactate levels were higher in the CRRT group at all timepoints compared to the non-CRRT group. In a multivariate model, lactate levels at 12 h post ICU admission [odds ratio (OR), 1.362; p = 0.007] was identified as an independent predictor for requiring CRRT. Unsurprisingly, 30-day mortality in the CRRT group (41%) was 8.2 times higher than in the non-CRRT group (5%). To better understand the associations between CRRT and lactate levels, patients in the CRRT group were further stratified into the non-survivor group (n = 41) and survivor group (n = 59) based on the 30-day mortality. Elevated lactate levels measured upon ICU admission (OR, 1.284; p = 0.001) and decreased 24 h lactate clearance (OR, 0.237; p = 0.039) were independent risk factors for 30-day mortality in patients who received CRRT. The area under the curve to predict requirement for CRRT at 6 and 12 h post CICU admission were 0.714 and 0.722, respectively, corresponding to lactate cut-off levels of 4.15 and 2.45 mmol/L.ConclusionThe CRRT is commonly required in patients who received ATAAD surgery and often associated with worse mortality. Early dynamic changes of lactate levels can be used to predict the requirement of postoperative CRRT.
Temporal Evolution of Island Arc Magmatism and Its Influence on Long-Term Climate: Insights From the Izu Intra-Oceanic Arc
Authors: Ribeiro Julia M. , Ishizuka Osamu , Pogge von Strandmann Philip A. E. , Tamura Yoshihiko , Xu Yi-Gang 
Published: July 2022

Continental arcs have an episodic magmatic activity over long-time periods, which is believed to modulate long-term climate. Island arcs have also the potential to release large amount of CO2 into the atmosphere, but whether they display an episodic magmatic history throughout their lifespan that contributes to the long-term (&gt;10 Ma) climate changes remains an open question. To set additional constraints on the magmatic history of island arcs, here we examine fresh basalts and mineral-hosted melt inclusions from the Izu intra-oceanic arc, shortly after the eruption of boninites (∼45 Ma ago). Using chemical markers, we show that the long-term magmatic activity of the mature Izu arc has been relatively continuous over its lifespan, except during opening of the Shikoku back-arc Basin (∼23–20 Ma). Because slab dehydration and slab melting trigger decarbonation and carbonate dissolution of the subducted plate, we use slab-fluid markers (Ba/Th, Cs/Th, Cs/Ba, Rb/Th, Th/Nb) to examine the variations of slab-derived CO2 captured by the arc magmas. The long-term steadiness in the arc magmatic activity and in the slab-fluid contribution suggests that the CO2 outgassed during mature arc volcanism may have remained relatively homogeneous for the past 40 Ma in Izu. If worldwide mature island arcs also maintain a relatively steady-state magmatic activity over their lifespan, the long-term CO2 outgassed by these arc volcanoes may be rapidly balanced by chemical weathering and tectonic erosion, which rapidly draw down the atmospheric CO2 (within 200–300 kyr). This rapid negative feedback to long-term volcanic degassing permits to sustain a viable atmospheric CO2 for millions of years. The lack of co-variations between the markers of climate changes (δ13O, δ18C) and the long-term averages of the markers of slab fluids further implies that long-term volcanic degassing of CO2 from mature island arcs might play a minor role in the slide into icehouse climatic conditions. This long-term degassing stability may be, instead, a contributor to maintaining a broadly stable climate over long timescales.
DNA damage repair-related gene signature predicts prognosis and indicates immune cell infiltration landscape in skin cutaneous melanoma
Authors: Liang Liping , Mai Shijie , Mai Genghui , Chen Ye , Liu Le 
Published: July 2022

BackgroundDNA damage repair plays an important role in the onset and progression of cancers and its resistance to treatment therapy. This study aims to assess the prognostic potential of DNA damage repair markers in skin cutaneous melanoma (SKCM).MethodIn this study, we have analyzed the gene expression profiles being downloaded from TCGA, GTEx, and GEO databases. We sequentially used univariate and LASSO Cox regression analyses to screen DNA repair genes associated with prognosis. Then, we have conducted a multivariate regression analysis to construct the prognostic profile of DNA repair-related genes (DRRGs). The risk coefficient is used to calculate the risk scores and divide the patients into two cohorts. Additionally, we validated our prognosis model on an external cohort as well as evaluated the link between immune response and the DRRGs prognostic profiles. The risk signature is compared to immune cell infiltration, chemotherapy, and immune checkpoint inhibitors (ICIs) treatment.ResultsAn analysis using LASSO-Cox stepwise regression established a prognostic signature consisting of twelve DRRGs with strong predictive ability. Disease-specific survival (DSS) is found to be lower among high-risk patients group as compared to low-risk patients. The signature may be employed as an independent prognostic predictor after controlling for clinicopathological factors, as demonstrated by validation on one external GSE65904 cohort. A strong correlation is also found between the risk score and the immune microenvironment, along with the infiltrating immune cells, and ICIs key molecules. The gene enrichment analysis results indicate a wide range of biological activities and pathways to be exhibited by high-risk groups. Furthermore, Cisplatin exhibited a considerable response sensitivity in low-risk groups as opposed to the high-risk incidents, while docetaxel exhibited a considerable response sensitivity in high-risk groups.ConclusionsOur findings provide a thorough investigation of DRRGs to develop an DSS-related prognostic indicator which may be useful in forecasting SKCM progression and enabling more enhanced clinical benefits from immunotherapy.
Heat Shock Proteins 70 Regulate Cell Motility and Invadopodia-Associated Proteins Expression in Oral Squamous Cell Carcinoma
Authors: Ding Le-Xi , Zhang Jing , Yang Si-Si , Wu Jin , Su Tong , Wang Wei-Ming 
Published: July 2022

BackgroundMany studies have shown that diabetes is often closely related to oral squamous cell carcinoma (OSCC) occurrence and metastasis. Heat shock protein 70 (Hsp70) is a molecular chaperone related to diabetes complications. This study aims to investigate the role of Hsp70 in OSCC in expression of invadopodia-associated proteins.MethodsThe expressions and correlation of HSP70, Hif1α, MMP2, MMP14, and cortactin were examined using bioinformatics analysis and verified by OSCC tissue microarrays. Assay in vitro was performed to analyze cell migration capacity after treatment with or without the HSP70 inhibitor.ResultsThe expressions of invadopodia-associated proteins were enhanced in OSCC tissues compared with paracarcinoma tissues and partially correlated with HSP70. Inhibiting HSP70 significantly decreased the cell viability, proliferation, and migration of OSCC cells.ConclusionsHSP70 may be involved in invadopodia-associated proteins in OSCC cells, which provides a promising method for treatment of OSCC metastasis.
The relationship between different iodine sources and nutrition in pregnant women and adults
Authors: Sun Rong , Fan Lijun , Du Yang , Liu Lanchun , Qian Tingting , Zhao Meng , Che Wenjing , Liu Peng , Sun Dianjun 
Published: July 2022

BackgroundDifferent iodine supplement measures emerge along with the economy development in China. The article objectives are to compare and explore the relationship between iodine sources and nutrition of pregnant women and adults.MethodsA total of 2,145 pregnant women and 1,660 adults were investigated by multi-stage random method. Questionnaire was used to collect basic information and the consumption of food, water, and iodine preparations. Household salt and individual urine and blood samples were collected, and thyroid function and morphology of pregnant women were measured.ResultsThe median urinary iodine concentration (MUIC) of pregnant women (164.49 μg/L) was lower than adults (187.30 μg/L, p &lt; 0.05). Iodine supplement with IS (iodized salt) was the main measure for pregnant women and adults, and the difference was mainly on the consumption of iodine preparations between pregnant women (5.19%) and adults (0.85%). Moreover, adults’ dietary iodine intake from food (100.6 μg/day), IS (140.8 μg/day), and drinking water (6.0 μg/day) was higher than those of pregnant women (86.5, 107.2, and 3.5 μg/day, respectively). Compared with iodine supplement with IS, ISFP (IS + iodine-rich food + iodine preparations) could reduce the risk of iodine deficiency for pregnant women. The MUICs for pregnant women and adults of iodine supplements with IF (iodine-rich food) and ISF (IS + iodine-rich food) were lower. For pregnant women, thyroid nodule (11.90%) and peroxidase antibody (TPOAb) positive (9.32%) were high prevalent thyroid diseases, and habitation (urban/rural), gestation, annual income, and drinking water type would affect them.ConclusionPregnant women and adults had adequate iodine nutrition in four provinces. Their iodine supplement measures were different, the consumption of iodine preparations in pregnant women was higher, and their dietary iodine intake was lower than adults. ISFP was an effect measure for pregnant women to supplement iodine.