bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer ego-system in glioma: an iron-replenishing niche network systemically self-organized by cancer stem cells
Authors: Tabu Kouichi , Taga Tetsuya 
Published: November 2022

AbstractFor all living organisms, the adaptation to outside environments is an essential determinant to survive natural and artificial selections and to sustain the whole ecosystem intact with functional biodiversity. Likewise, cancer cells have similar characteristics that evade not only stresses from the host-internal innate and adaptive immune systems but also those from host-externally administered therapeutic interventions. Such selfish characteristics of cancer cells lead to the formation of cancerous ecosystem with a wide variety of phenotypic heterogeneity, which should be called cancer “egosystem” from the host point of view. Recently increasing evidence demonstrates that cancer stem cells (CSCs) are responsible for this cancer egosystem by effectively exploiting host inflammatory and hematopoietic cells and thereby reconstructing their own advantageous niches, which may well be a driving force in cancer recurrence. CSCs are further likely to render multiple niches mutually interconnected and cooperating as a network to support back CSCs themselves. Here, we summarize a recently identified iron-replenishing niche network self-organized by glioma CSCs (GSCs) through remote regulation of host myeloid and erythroid lineage cells. GSCs recruit bone marrow (BM)-derived inflammatory monocytes into tumor parenchyma, facilitate their differentiation into macrophages (Mφs) and skew their polarization into pro-tumoral phenotype, i.e., tumor-associated Mφs (TAMs). Meanwhile, GSCs distantly enhance erythropoiesis in host hematopoietic organs like BM and spleen potentially by secreting some soluble mediators that maintain continuous supply of erythrocytes within tumors. In addition, as normal red pulp Mφs (RPMs) under steady state conditions in spleen recycle iron by phagocytosing the aged or damaged erythrocytes (a/dECs) and release it in time of need, TAMs at least in gliomas phagocytose the hemorrhaged erythrocytes within tumors and potentially serve as a source of iron, an important nutrient indispensable to GSC survival and glioma progression. Taken together, these studies provide the substantial evidence that CSCs have a unique strategy to orchestrate multiple niches as an ecosystem that threatens the host living, which in this sense must be an egosystem. Targeting such an adaptive subpopulation of CSCs could achieve drastic disturbance of the CSC niches and subsequent extinction of malignant neoplasms.
Hawkes process marked with topics and its application to Twitter data analysis
Authors: Goda Masatoshi , Mizuno Takayuki , Yano Ryosuke 
Published: November 2022

Abstract
On Twitter, complex networks of information propagation are observed. In this article, we propose a method to model the time interval of user's tweets by combining the marked Hawkes process and the Latent Dirichlet Allocation method. We also propose a method that quantifies how individual topics in tweets excite future tweets and visualize the results as a topic-wise Hawkes graph. As an application to actual data, we analyze the tweets from the American, Chinese, and British embassies from February 1, 2020, to September 27, 2020, a period that roughly corresponds to the initial outbreak of the COVID-19 pandemic.
Maternal Diabetes in Youth-Onset Type 2 Diabetes Is Associated With Progressive Dysglycemia and Risk of Complications
Authors: Shah Rachana D , Chernausek Steven D , El ghormli Laure , Geffner Mitchell E , Keady Joyce , Kelsey Megan M , Farrell Ryan , Tesfaldet Bereket , Tryggestad Jeanie B , Van Name Michelle , Isganaitis Elvira 
Published: November 2022

Abstract

Context
Prenatal exposures, including undernutrition, overnutrition, and parental diabetes, are recognized risk factors for future cardiometabolic disease. There are currently no data on effects of parental diabetes on disease progression or complications in youth-onset type 2 diabetes (T2D).

Objective
We analyzed effects of parental diabetes history on glycemic outcomes, β-cell function, and complications in a US cohort of youth-onset T2D.

Methods
Participants (N = 699) aged 10 to 17 years with T2D were enrolled at 15 US centers and followed for up to 12 years as part of the TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) and TODAY2 follow-up studies. Information about diabetes diagnosis in biological mothers was available for 621 participants (never = 301; before or during pregnancy = 218; after pregnancy = 102) and in biological fathers for 519 (no diabetes = 352; paternal diabetes = 167).

Results
Maternal, but not paternal, diabetes was associated with loss of glycemic control over time, defined as glycated hemoglobin A1c greater than or equal to 8% for more than 6 months (P = .001). Similarly, maternal, but not paternal, diabetes was associated with increased risk of glomerular hyperfiltration (P = .01) and low heart rate variability (P = .006) after 12 years of follow-up. Effects were largely independent of age, sex, race/ethnicity, and household income. Maternal diabetes during vs after pregnancy had similar effects on outcomes.

Conclusion
Maternal diabetes, regardless of whether diagnosed during vs after pregnancy, is associated with worse glycemic control, glomerular hyperfiltration, and reduced heart rate variability in youth with T2D in TODAY. The strong associations of diabetes outcomes with maternal diabetes suggest a possible role for in utero programming.
You Forbid Me to Walk: Yokota Hiroshi's Disability Poetics
Authors: Campana Andrew 
Published: November 2022

Abstract
This article explores the work of the poet Yokota Hiroshi, a leader in Japan's disability rights movement, and how he used his experiences of having cerebral palsy to create a new kind of disability poetics. Like in much of the world, Japan in the 1970s saw the emergence of disability movements that aimed to challenge the inaccessibility and cruelty of a society made by and for nondisabled people. Yokota was involved with two key groups of this kind—the literary coterie Shinonome and the activist group Aoi Shiba no Kai—and over several decades published multiple books about the ideologies that justified killing disabled people and the construction of disabled society and culture, as well as several books of poetry. In his poems, he aimed not only to shed light on the oppression and dehumanization of disabled people but to rethink dominant conceptions of embodiment and “able-bodiedness” itself.
Archipelagic Optics in Wu Ming-Yi's The Man with the Compound Eyes
Authors: Chang Yi-Ting 
Published: November 2022

Abstract
In transpacific and Asian/American studies, islands often gain decolonial meaning via their explicit ties to US and Japanese military imperialisms. This article inquires how islands express the decolonial beyond US-centric anti-imperial critique, and how they complicate the fields’ geopolitical imagination largely defined by the category of independent nation-states. To that end, the author turns to Taiwanese writer Wu Ming-Yi's The Man with the Compound Eyes and develops “archipelagic optics” as a transpacific interpretive framework—one that includes the decontinental in its decolonial thesis. Archipelagic optics takes liminal islands such as Taiwan and the Great Pacific Garbage Patch as its epistemic grounds; it advances a multicentered epistemology in order to articulate inter- and intra-island contradictions; and it foregrounds “interdependence” rather than “independence” as an ontopolitical premise of archipelagic lives. Archipelagic optics indexes a form of decolonial sensing by refuting the impersonal, monocular eye of military cameras used by multiple empires to surveil Pacific islands. As this article will demonstrate, the decolonial goes beyond the deconstruction of military intercolonialism. It also means tracing noninnocent multiplicity, decontinental seeing, and immanent dependencies emerging from formerly “obscure” sites.
Case Report: Spontaneous remission of early T-cell precursor acute lymphoblastic leukemia
Authors: Cherif Amira , Saada Veronique , Bouatay Amina 
Published: November 2022

Background: Spontaneous remission (SR) has been reported in different hematological malignancies. It has been observed in adult T-cell lymphoma, chronic lymphocytic leukemia (CLL) and myelodysplastic syndrome (MDS). It is generally associated with recovery from an infectious or immunological process, and more recently possibly with clonal hematopoiesis. Case: We reviewed the literature and reported a new case of a 40 year-old man with a morphologic and cytogenetic diagnosis of early T-cell precursor acute lymphoblastic leukemia (ALL) associated with an appendicular abscess. During his hospitalization and surgical management of his appendicitis, we noted SR of the rate of blast cells until cytological and cytogenetic remission of his ALL but unfortunately it did not last too long, moreover our patient relapsed after nine months, received intensive chemotherapy, underwent a placental blood allograft but relapsed again and died. Conclusions: In contrast to SR in other types of cancer, all documented cases of SR in ALL were only transient, so is there a need for early cytotoxic therapy in SR in ALL to delay relapse?
“Lo somni”, en la línea del ensayo moderno
Authors: Butinyà Júlia 
Published: November 2022

This study is an application of the notes about modern essay to the important Bernat Metge’s dialogue Lo somni, the first and most important work of Catalan Humanism.The result of this study is that this work can be considered as a precedent of this genre, as has been the case with Seneca’s epistles.
De género y de géneros: Victoria Ocampo, traductora de Colette: “Gigi”
Authors: Zenarruza de Clément Silvia 
Published: November 2022

Victoria Ocampo has been an agent of hybridization in Argentinean literature, acting as a bridge that has fostered the exchange of literary ideas between Argentina, Europe and the United States. This is precisely what she did with her translation of Gigi, by Colette. In this essay we aim at the study of the many ties, parallels, and overlaps existing between Ocampo and Colette.
VELÁZQUEZ GARCÍA, S. (Universidad de Salamanca): EL NEORREALISMO ITALIANO. INFLUENCIA EN EL CINE ESPAÑOL DE LOS AÑOS CINCUENTA
Authors: VELÁZQUEZ GARCÍA Sara 
Published: November 2022

Este artículo se propone ofrecer un panorama de la recepción del cine neorrealista italiano en España desde sus inicios, con atención especial a algunos de sus títulos más emblemáticos, así como a los directores, productores y realizadores más importantes. El cine español de los 50 adoptó muchas de las características principales de esta corriente italiana permitiendo el surgimiento de algunos de los títulos principales de la cultura española de la época. A pesar del fuerte componente ideológico del regimen franquista, la influencia del Neorrealismo italiano dio lugar a una escuela cinematográfica que contribuyó al enriquecimiento del patrimonio cultural de nuestro país, gracias a autores como Juan Antonio Bardem, Luis García Berlanga y José Antonio Nieves Conde.
PENAS IBÁÑEZ, Beatriz & GARCÍA LANDA, José Ángel (UZ): “Art, Truth, and Politics” de Harold Pinter (2005): traducción de un texto culturalmente relevante.
Authors: PENAS IBÁÑEZ Beatriz 
Published: November 2022

La presente contribución ofrece al lector en lengua castellana la posibilidad de leer –en su versión traducida al español– el discurso que Harold Pinter, el reconocido dramaturgo británico fallecido en 2008, compuso para su presentación “in absentia” ante la Real Academia Sueca en diciembre de 2005, con ocasión de la entrega que se le hizo del premio Nobel de Literatura el día siete de dicho mes y año. Se trata de un texto del que sólo encontraremos las traducciones al francés, sueco y alemán que acompañan al original inglés en la página web de la Fundación Nobel. Por eso esta traducción al español parece necesaria. El discurso de Pinter es un texto importante al que los lectores de lengua española también han de tener acceso por el interés de las ideas en él desarrolladas y por la valentía con que dichas ideas fueron expuestas a la luz pública.
Design of DWDM optical communication systems with different modulation formats using DCF and a repeater
Authors: Akram Dina S. , Al-Tamimi Haydar M. 
Published: November 2022

The dense wavelength division multiplexing (DWDM) technique has been used to provide a large capacity and low bandwidth loss for optical communication systems. In this paper, simulation designs by Optisystem15.0 of carrier-suppressed return to zero (CSRZ), differential phase shift keying (DPSK), and intensity modulation is proposed to determine which modulation format is more compatible with four and eight DWDM channels for transmitting an optical signal over 400 km distance. For a long optical path, the dispersion compensation fiber (DCF) technique is proposed to eliminate dispersion effects and increase the possibility of transmitting multiple optical wavelengths over long single-mode fiber. Optical amplifiers are used to amplify the optical signal with a distorted signal and process the attenuation caused by the long transmission distance. In DCF network design, CSRZ offers the best performance because of the large quality factor (24.560) and high threshold power (15 dBm), which make the system compatible with increased distance between the transmitter and receiver; next is intensity modulation with a 24.5604 quality factor and 13 dBm threshold power value; DPSK comes in last with the worst performance, with a quality factor of 10 at 13 dBm power due to non-linear effects, especially non-linear phase noise. In the repeater design, the DPSK modulation format has the best performance with a large quality factor of 20.7913 at a high threshold power of 14 dBm for 150 GHz spacing; this is because the repeater technique is compatible with reducing the non-linear effects of the DPSK format. CSRZ and intensity modulation have the same performance with a 12 quality factor at 4 dBm power for intensity modulation and 3 dBm power for CSRZ modulation.
Evaluation of Subjective Image Quality with the Square Root Integral Method
Authors: Barten Peter G. J. 
Published: November 2022

After a short survey of some other measures of perceived image quality, the recently proposed square root integral (SQRI) is described, with special attention to the way in which this measure takes the effect of various display parameters into account.
Experimental data on subjective image quality at varying resolution, addressability, contrast, luminance and display size are compared with predictions by the square root Integral. From the comparison it appears that there is a high correlation between perceived image quality and calculated SQRI value.
COVID-19 associated changes in HIV service delivery over time in Central Africa: Results from facility surveys during the first and second waves of the pandemic
Authors: Rogers Ajeh , Brazier Ellen , Dzudie Anastase , Adedimeji Adebola , Yotebieng Marcel , Muhoza Benjamin , Twizere Christella , Lelo Patricia , Nsonde Dominique , Mafoua Adolphe , Munyaneza Athanase , Gateretse Patrick , Diafouka Merlin , Murenzi Gad , Niyongabo Théodore , Anastos Kathryn , Nash Denis 
Published: November 2022

Introduction
The COVID-19 pandemic has impacted population health around the globe, directly and indirectly. The objective of this study was to document changes in HIV care associated with the COVID-19 pandemic at selected clinics in Central Africa, along with clinic-level strategies for minimizing disruptions in HIV care and treatment for people with HIV (PWH).

Methods
A 51-item questionnaire on COVID-19 pandemic-associated changes in HIV service delivery was completed by clinicians involved in HIV care at 21 clinics in five countries participating in Central Africa International epidemiology Databases to Evaluate AIDS (CA-IeDEA). The survey was completed at two timepoints: June-July 2020 and October 2020 to February 2021. Descriptive statistics were used to characterize changes in HIV care and related services.

Results
While 81% of sites reported at least one negative consequence of COVID-19 for clinic operations during the first survey, none reported suspending antiretroviral therapy (ART) initiation services for new patients, and 24% reported adopting telemedicine. In the follow-up survey, fewer sites (48%) reported at least one disruption to clinic operations, and more sites reported mitigation strategies, including expanding rapid ART initiation services and providing extra supplies of ART medications to reduce visit frequency. In the follow-up survey, more sites, especially in Rwanda, reported stockouts of commodities, including HIV and viral load testing and HIV pre-exposure prophylaxis. More than one-fifth of sites reported stockouts of second- or third-line ART at each survey timepoint.

Conclusions
While the initial wave of the COVID-19 pandemic resulted in concerning disruptions to HIV service delivery at CA-IeDEA sites, most of these disruptions attenuated over time, and many sites introduced measures to help PWH avoid frequent visits to the clinic for care and medications. The impact of HIV commodity stockouts and clinic mitigation strategies on treatment outcomes needs to be assessed.
Effects of smoking cessation using varenicline on the serum concentrations of oxidized high-density lipoprotein: Comparison with high-density lipoprotein cholesterol
Authors: Umeda Akira , Miyagawa Kazuya , Mochida Atsumi , Takeda Hiroshi , Ohira Yoshiyuki , Kato Toru , Okada Yasumasa , Kotani Kazuhiko 
Published: November 2022

Background
The oxidized high-density lipoprotein (oxHDL) is a possible marker for cardiovascular diseases. This study investigated the effects of smoking cessation with varenicline (a partial agonist of nicotinic acetylcholine receptors) on the levels of oxHDL in the serum of subjects compared with those of high-density lipoprotein cholesterol (HDL-C).

Methods
Data of 99 nicotine-dependent adult subjects who visited the smoking cessation outpatient services at International University of Health and Welfare Shioya Hospital were reviewed. Each subject was treated with varenicline titrated up to 1.0 mg twice daily for 12 weeks. Serum levels of oxHDL and HDL-C were repeatedly measured by enzyme-linked immunosorbent assay and enzymatic method, respectively.

Results
The serum levels of oxHDL were significantly decreased from 163.2 ± 96.6 to 148.3 ± 80.7 U/mL (p = 0.034, n = 99). This effect was more prominent when the data of subjects in whom the treatment was objectively unsuccessful (exhaled carbon monoxide at 3 months ≥ 10 ppm) were omitted (from 166.6 ± 98.4 to 147.4 ± 80.6 U/mL; p = 0.0063, n = 93). In contrast, the serum levels of HDL-C were significantly increased (p = 0.0044, n = 99). There was a close relationship between the baseline levels of oxHDL and HDL-C (R = 0.45, p < 0.0001, n = 99). Changes in the levels of oxHDL were closely associated with changes in the levels of exhaled carbon monoxide in subjects in whom smoking cessation with varenicline was very effective (decrease in exhaled carbon monoxide by ≥ 15 ppm after treatment with varenicline; R = 0.42, p = 0.0052, n = 43).

Conclusions
Although there was a close relationship between the baseline serum concentrations of oxHDL and HDL-C, smoking cessation decreased oxHDL and increased HDL-C. This effect on oxHDL may be associated with the effectiveness of smoking cessation.
A protocol to identify the barriers and facilitators for people with severe mental illness and/or learning disabilities for PErson Centred Cancer Screening Services (PECCS)
Authors: Sykes Kate , Tuschick Emma , Giles Emma L. , Kanmodi Kehinde K. , Barker Jill 
Published: November 2022

Objectives
To identify the barriers and facilitators that people with severe mental illness and people with learning disabilities may encounter when accessing cancer screening and make recommendations for implementing reasonable adjustments throughout cancer screening services.

Methods and analysis
An 18-month sequential, mixed-methods study comprising of two phases of work and underpinned by Normalisation Process Theory, recruiting from across the North-East and North Cumbria. The first phase aims to identify the barriers and facilitators for people with severe mental illness in accessing cervical, breast and colorectal cancer screening. A systematic review of eight databases (Part 1a; PROSPERO registration number: CRD42022331781) alongside semi-structured interviews of up to 36 people with severe mental illness (Part 1b) will occur. Additional characteristics indicating populations whose perspectives may not have been accounted for in the systematic review will be targeted in the interviews. Potential participants will be identified from a range of settings across the North-East and North Cumbria, including through social media and gatekeepers within National Health Service Trusts and charities. Interviews will be analysed using framework analysis, which will be in line with the Normalisation Process Theory. The second phase of the project (part 2a) involves triangulating the results of the systematic review and interviews with existing research previously completed with people with learning disabilities accessing cancer screening. This will be to identify population specific barriers and facilitators across people with learning disabilities and people with severe mental illness to access cancer screening services. Following triangulation, part 2b will include designing and planning a future study involving stakeholders in cancer screening to explore the feasibility, practicality, and priority for implementing the recommendations to improve person centred cancer screening services (PECCS).

Ethics and dissemination
This study has received Teesside University ethical approval, Health Research Authority approval (IRAS: 310622) and favourable opinion (REF: 22/PR/0793). Findings will be disseminated through a range of academic and non-academic modes including infographics, blog posts and academic publications.
The French version of the Gilles de la Tourette Syndrome Quality of Life Scale for adolescents (GTS-QOL-French-Ado): Adaptation and psychometric evaluation
Authors: Jalenques Isabelle , Guiguet-Auclair Candy , Cyrille Diane , Debosque Clement , Derost Philippe , Hartmann Andreas , Lauron Sophie , Jameux Clara , Tauveron—Jalenques Urbain , Rondepierre Fabien ,   for The Syndrome de Gilles de La Tourette Study Group
Published: November 2022

Introduction
The aim of this study was to create a new version of the French GTS-QOL adapted to adolescents with GTS aged 12–16 years (GTS-QOL-French-Ado) and to evaluate its psychometric properties.

Methods
We assessed the psychometric properties of the GTS-QOL-French-Ado in 84 adolescents (mean age 13.6 years, standard deviation 1.2) in terms of factor structure, internal consistency, reliability and convergent validity with the Child Depression Inventory (CDI), the Multidimensional Anxiety Scale for Children (MASC), the Motor tic, Obsessions and compulsions, Vocal tic Evaluation Survey (MOVES) and the French “Vécu et Santé Perçue de l’Adolescent” (VSP-A), a generic self-administered measure of health-related quality of life (HRQoL) in adolescents.

Results
Exploratory factor analysis of the GTS-QOL-French-Ado resulted in a 5-factor solution. The GTS-QOL-French-Ado demonstrated good acceptability with missing values per subscale ranging from 0% to 1.2%, good internal consistency for four of the five subscales with Cronbach’s alpha ranging from 0.56 to 0.87 and good test–retest reliability with intraclass correlation coefficients ranging from 0.74 (95% CI: 0.52–0.86) to 0.82 (95% CI: 0.66–0.91). Convergent validity was supported by correlations with CDI, MASC, MOVES, VSP-A and clinical variables.

Discussion
The GTS-QOL-French-Ado is the first disease-specific HRQoL tool for French-speaking adolescents with GTS aged 12–16 years, and shows good psychometric properties. Further psychometric testing on responsiveness to change would be of great interest.