bluuebunny/crossref_metadata_2025_split huggingface dataset:
The ideal site of cement application in cement augmented sacroiliac screw fixation: the biomechanical perspective
Authors: Albers Christoph Emanuel , Zderic Ivan , Kastner Philipp , Gueorguiev Boyko , Tosounidis Theodoros Herkules , Keel Marius Johann Baptist , Bastian Johannes Dominik 
Published: December 2022

AbstractPurposeTo compare construct stability of cement augmented sacroiliac screws using two different cementation sites in a biomechanical fragility fracture model of the pelvis.MethodsA fracture model with an incomplete fracture of the sacral ala and complete fracture of the anterior pelvic ring mimicking a FFP IIB fragility fracture of the pelvis was established in five fresh frozen human cadaveric pelvises. Sacral fracture stabilization was achieved with bilateral 7.3 mm fully threaded sacroiliac screws. Cement augmentation was performed at the tip of the screw (body of S1; Group A) on one side, and at the midshaft of the screw (sacral ala; Group B) on the contralateral side. Biomechanical testing was conducted separately on both sides comprising cyclic loading of axial forces transferred through the tested hemipelvis from L5 to the ipsilateral acetabulum. Combined angular displacement in flexion and internal rotation (“gap angle”), angular displacement of the ilium in relation to the screw (“screw tilt ilium”), and screw tip cutout were evaluated.ResultsRelative interfragmentary movements were associated with significantly higher values in group A versus group B for “gap angle” (2.4° vs. 1.4°;p < 0.001), and for “screw tilt ilium” (3.3° vs. 1.4°;p < 0.001), respectively. No significant difference was indicated for screw tip cutout between the two groups (0.6 mm [Group A] vs. 0.8 mm [Group B];p = 0.376).ConclusionThe present study demonstrated less fragment and screw displacements in a FFP IIB fracture model under physiologic cyclic loading by cement augmentation of sacroiliac screws at the level of the lateral mass compared to the center of vertebral body of S1.
Multiple myeloma, a quintessential malignant disease of aging: a geroscience perspective on pathogenesis and treatment
Authors: Urban Veronika S. , Cegledi Andrea , Mikala Gabor 
Published: December 2022

AbstractMultiple myeloma (MM) is an incurable plasma cell malignancy, which is predominantly a disease of older adults (the median age at diagnosis is 70 years). The slow progression from asymptomatic stages and the late-onset of MM suggest fundamental differences compared to many other hematopoietic system-related malignancies. The concept discussed in this review is that age-related changes at the level of terminally differentiated plasma cells act as the main risk factors for the development of MM. Epigenetic and genetic changes that characterize both MM development and normal aging are highlighted. The relationships between cellular aging processes, genetic mosaicism in plasma cells, and risk for MM and the stochastic processes contributing to clonal selection and expansion of mutated plasma cells are investigated. In line with the DNA damage accumulation theory of aging, in this review, the evolution of monoclonal gammopathy to symptomatic MM is considered. Therapeutic consequences of age-dependent comorbidities that lead to frailty and have fundamental influence on treatment outcome are described. The importance of considering geriatric states when planning the life-long treatment course of an elderly MM patient in order to achieve maximal therapeutic benefit is emphasized.
Low-Grade Hepatic Steatosis Is Associated with Long-term Remission of Type 2 Diabetes Independent of Type of Bariatric-Metabolic Surgery
Authors: Lautenbach Anne , Wernecke Marie , Mann Oliver , Wagner Jonas , Wolter Stefan , Stoll Fabian , Aberle Jens 
Published: December 2022

Abstract

Background
Bariatric-metabolic surgery (BS) decreases the grade of steatosis, hepatic inflammation, and fibrosis in patients with severe obesity and non-alcoholic fatty liver disease (NAFLD). Mechanisms include substantial weight loss, but also simultaneous effects on glucose homeostasis. Therefore, we aimed to investigate the association between NAFLD and remission of type 2 diabetes (T2D) up to 8 years following different types of BS.

Methods
In a retrospective cohort study including 107 patients with obesity and T2D at baseline, the association between biopsy-proven NAFLD defined as steatosis in > 5% of hepatocytes at the time of surgery and T2D remission up to 8 years following different surgical procedures was investigated. Univariate regression analysis was used to examine the association between NAFLD and remission of T2D.

Results
Long-term remission of T2D was present in 56% of patients (n = 60). The presence of low-grade liver steatosis (grade 1) was associated with remission of T2D. Patients with a liver steatosis score ≥ 2 showed higher HbA1c levels at baseline. There were no significant differences in preoperative presence of lobular inflammation, hepatocyte ballooning, or fibrosis between patients who achieved T2D remission compared with those with no remission. Type of surgery did not affect remission of T2D.

Conclusion
Our results suggest that the presence of low-grade liver steatosis is associated with remission of T2D following sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). Therefore, BS should be considered at an early NAFLD stage in patients with T2D.

Graphical Abstract
Ageing in Place Classification: Creating a geodemographic classification for the ageing population in England
Authors: Yang Yuanxuan , Dolega Les , Darlington-Pollock Fran 
Published: December 2022

Abstract
Population ageing is one of the most significant demographic changes underway in many countries. Far from being a homogenous group, older people and their experiences of ageing are diverse. A better understanding of the characteristics and geography of the older population, including the older workforce, is important. It allows policymakers and stakeholders to better adapt to the opportunities and challenges that the ageing population brings. This paper describes the implementation of the Ageing in Place Classification (AiPC) in England. AiPC is a multidimensional geodemographic classification, and it employs a wide range of spatially representative attributes of older people’s sociodemographic characteristics and their living environment at the small area level. The openly available product provides valuable insights that can be implemented in both local and national contexts, in particular to improve service delivery and inform targeted policy interventions. AiPC is readily updateable with the arrival of new Census data; the concept and framework are also transferable to other countries.
OrBITS: label-free and time-lapse monitoring of patient derived organoids for advanced drug screening
Authors: Deben Christophe , De La Hoz Edgar Cardenas , Compte Maxim Le , Van Schil Paul , Hendriks Jeroen M.H. , Lauwers Patrick , Yogeswaran Suresh Krishan , Lardon Filip , Pauwels Patrick , Van Laere Steven , Bogaerts Annemie , Smits Evelien , Vanlanduit Steve , Lin Abraham 
Published: December 2022

Abstract
Background
Patient-derived organoids are invaluable for fundamental and translational cancer research and holds great promise for personalized medicine. However, the shortage of available analysis methods, which are often single-time point, severely impede the potential and routine use of organoids for basic research, clinical practise, and pharmaceutical and industrial applications.

Methods
Here, we developed a high-throughput compatible and automated live-cell image analysis software that allows for kinetic monitoring of organoids, named Organoid Brightfield Identification-based Therapy Screening (OrBITS), by combining computer vision with a convolutional network machine learning approach. The OrBITS deep learning analysis approach was validated against current standard assays for kinetic imaging and automated analysis of organoids. A drug screen of standard-of-care lung and pancreatic cancer treatments was also performed with the OrBITS platform and compared to the gold standard, CellTiter-Glo 3D assay. Finally, the optimal parameters and drug response metrics were identified to improve patient stratification.

Results
OrBITS allowed for the detection and tracking of organoids in routine extracellular matrix domes, advanced Gri3D®-96 well plates, and high-throughput 384-well microplates, solely based on brightfield imaging. The obtained organoid Count, Mean Area, and Total Area had a strong correlation with the nuclear staining, Hoechst, following pairwise comparison over a broad range of sizes. By incorporating a fluorescent cell death marker, intra-well normalization for organoid death could be achieved, which was tested with a 10-point titration of cisplatin and validated against the current gold standard ATP-assay, CellTiter-Glo 3D. Using this approach with OrBITS, screening of chemotherapeutics and targeted therapies revealed further insight into the mechanistic action of the drugs, a feature not achievable with the CellTiter-Glo 3D assay. Finally, we advise the use of the growth rate-based normalised drug response metric to improve accuracy and consistency of organoid drug response quantification.

Conclusion
Our findings validate that OrBITS, as a scalable, automated live-cell image analysis software, would facilitate the use of patient-derived organoids for drug development and therapy screening. The developed wet-lab workflow and software also has broad application potential, from providing a launching point for further brightfield-based assay development to be used for fundamental research, to guiding clinical decisions for personalized medicine.
Sequence effects on the life estimation of thin-walled welded tubular structures made of HSS + UHSS under bending
Authors: Neuhäusler Josef , Roth Jakob , Oswald Markus , Dürr André , Rother Klemens 
Published: December 2022

AbstractWelded hollow sections are typical in different industries. A database of fatigue life data of welded hollow section joints covering sequence effects and the accuracy of the linear damage accumulation is presented. The effects of the shape of the applied load spectra, sequence effects of different amplitudes have been investigated using two high-strength steels. This document covers thin-walled tubes of 2-mm thickness made of low-carbon or mild steel 1.8849 (S460MH) and austenitic TWIP-steel 1.4678 + CP700 (X30MnCrN16-14). Constant amplitude and two-level load spectra are presented to check the linear damage accumulation. Using stress concentration factors from finite element analysis, typical FAT classes for the structural and the effective notch stress concepts are checked as well. Both structures show much higher strength compared IIW recommendations by structural stress approach and DVS 0905 by effective notch stress approach. Typical maximum linear damage sums taken from recommendations and codes of 0.2 or 0.5 are exceeded for all spectra investigated and in some of the cases even significantly above 1.0. Transferability of the recommendations to component type structures like those tubular joints made of high-strength steel needs revision to lift its lightweight potential but this will require additional data.
Facile fabrication, structural and electrical investigations of cadmium sulfide nanoparticles for fuel cell performance
Authors: Ramadan Mervet , Elnouby Mohamed S. , El-Shazly O. , El-Wahidy E. F. , Farag A. A. M. , Roushdy N. 
Published: December 2022

AbstractIn the present work, CdS nanoparticles were synthesized and analyzed for use in fuel cell applications. The X-ray diffraction investigation showed that CdS possesses a cubic polycrystalline structure. For the (111) plane, the average values of mean crystallite size, microstrain, and dislocation density were calculated and found to be 1.935 nm, 0.0758, and 0.267 nm−2. The average crystallite size was additionally calculated and found to be 2.02 nm using the modified Scherrer’s plot. The observed blue shift in the photoluminescence of CdS is caused by the quantum size impact of the nanocrystalline structure. A broad emission band at 590 nm is produced by the recombination of a hole in the valence band of CdS with an electron confined in a sulfur vacancy. The average Cd/S ratio is good and comparable, according to the EDS analysis, which is close to the theoretical values and almost exactly fits the ideal structure. A thermogravimetry diagram was used to establish the thermal stability of CdS across a wide range of temperatures. Fuel cell application features peaks were investigated by the cyclic voltammetry of CdS under various conditions. The linear sweep voltammetry was used to analyze the electrochemical performance of CdS electrodes in fuel cells. Electrochemical impedance spectroscopy (EIS) was also used and the results confirmed that nickel substrate is regarded as being superior to stainless steel in terms of performance.
Community-Based Culturally Tailored Education Programs for Black Communities with Cardiovascular Disease, Diabetes, Hypertension, and Stroke: Systematic Review Findings
Authors: Singh Hardeep , Fulton Joseph , Mirzazada Sofia , Saragosa Marianne , Uleryk Elizabeth M. , Nelson Michelle L. A. 
Published: December 2022

Abstract

Background
Community-based culturally tailored education (CBCTE) programs for chronic diseases may reduce health disparities; however, a synthesis across chronic diseases is lacking. We explored (1) the characteristics and outcomes of CBCTE programs and (2) which strategies for culturally appropriate interventions have been used in CBCTE programs, and how they have been implemented.

Methods
A systematic review was conducted by searching three databases to identify empirical full-text literature on CBCTE programs for Black communities with cardiovascular disease, hypertension, diabetes, or stroke. Studies were screened in duplicate, then data regarding study characteristics, participants, intervention, and outcomes were extracted and analyzed. Cultural tailoring strategies within programs were categorized using Kreuter and colleagues’ framework.

Results
Of the 74 studies, most were conducted in the USA (97%) and delivered in one site (53%; e.g., church/home). CBCTE programs targeted diabetes (65%), hypertension (30%), diabetes and hypertension (1%), cardiovascular disease (3%), and stroke (1%). Reported program benefits included physiological, medication-related, physical activity, and literacy. Cultural tailoring strategies included peripheral (targeted Black communities), constituent-involving (e.g., community informed), evidential (e.g., integrated community resources), linguistic (e.g., delivered in community’s dialect/accent), and sociocultural (e.g., integrated community members’ religious practices).

Conclusions
CBCTE programs may have beneficial outcomes, but a small sample size limited several. The strategies identified can be adopted by programs seeking to culturally tailor. Future interventions should clearly describe community members’ roles/involvement and deliver programs in multiple locations to broaden reach.

Trial Registration
PROSPERO CRD42021245772.
Schriftstrukturorientierte Zugänge zur Alphabetisierung erwachsener Zugewanderter aus der Sicht von Lehrkräften
Authors: Waschewski Tina , Grotlüschen Anke , Müller Astrid 
Published: December 2022

ZusammenfassungDie Nachfrage nach Integrationskursen mit Alphabetisierung ist stark gestiegen, gleichzeitig sinken die Erfolgsdaten dieser Kurse kontinuierlich ab. Die gängigen, lautorientierten Alphabetisierungskonzepte führen nicht zum erwünschten Erfolg. Schriftstrukturorientierte Ansätze, die in allgemeinbildenden Schulen ihre Lernwirksamkeit gezeigt haben, werden in den Alphabetisierungskursen allerdings bislang kaum berücksichtigt. Hier setzt das Forschungsprojekt an. In Workshops konnten Kursleitungen einen schriftstrukturorientierten Ansatz kennenlernen. Anschließend wurden sie in Interviews dazu befragt, ob, und wenn ja, mit welchen Anpassungen dieser Ansatz in den Alphabetisierungskursen eingesetzt werden kann. Die Argumente wurden systematisiert und zeigen Chancen und Grenzen der Übertragbarkeit auf.
Antioxidant and anticancer properties of nano and fermented-nano powders of wheat and rice by-products
Authors: Yousif El-Sayed , Yaseen Attia , Abdel-Fatah Abdel-Fatah , Shouk Abdel-Hafeez , Gdallah Mohamed , Mohammad Ayman 
Published: December 2022

AbstractIn this study, nano and fermented-nano powders of wheat and rice by-products were prepared by superfine grinding of raw and solid-state fermented materials. Effects of fermentation and superfine grinding on phytochemical content, phenolic acids profile as well as antioxidant and anticancer activity were investigated. The results revealed that, phenolic contents of fermented-nano wheat bran (FNWB), fermented-nano wheat germ (FNWG) and fermented-nano rice bran (FNRB) increased by 40.5, 59.2 and 27.9%, respectively compared to their raw samples. The free, conjugated and bound forms of most identified phenolic acids apparently increased. Also, the antioxidant activity of nano and fermented-nano forms significantly increased compared to its raw materials. The anticancer activity of nano and fermented-nano materials against human colon cancer cell line (HCT 116) increased compared to its raw materials. Nano rice bran (NRB) extract was the most effective one with IC50 value of 4.10 mg/mL under the investigated condition. The obtained results indicated that superfine grinding and solid-state fermentation could change the rigid microstructure and liberate bioactive compounds, which enhanced their bio-accessibility and bioavailability to improve bran functionality and usability.
Psychotherapists’ views on triggering factors for psychological disorders
Authors: Riachi Eve , Holma Juha , Laitila Aarno 
Published: December 2022

AbstractTriggering factors play an important role in the development of psychological disorders. Practicing psychotherapists have valuable knowledge on psychological disorders and since their views on triggering factors have not been reported in the literature, triggers were addressed in this study from psychotherapists’ perspectives. The following three main issues were examined: definitions of triggers, examples of the most recurrent triggers and the idea of a common trigger for psychological disorders. Sixteen psychotherapists agreed to participate in the study. Semi-structured interviews were conducted in person and the data collected were analyzed using frame analysis. Frame analysis aims at representing the data through frames or groups that indicate different interpretations of the same topic. The results showed that the therapists provided three definitions of triggering factors. They most often defined triggers as events, occurrences or situations that explain the onset of psychological symptoms. The psychotherapists also provided examples of triggering factors: these were grouped into three frames, interpersonal, environmental and trauma. The therapists identified no single common trigger, although they discussed common categories and connections between different triggering factors. The findings indicate that triggering factors are complex and closely connected to personal vulnerabilities, as different events and circumstances act as triggers for different individuals. Future research could expand on these findings by examining the constituents of individual vulnerabilities.
Mental Imagery and the Epistemology of Testimony
Authors: Munro Daniel 
Published: December 2022

AbstractMental imagery often occurs during testimonial belief transmission: a testifier often episodically remembers or imagines a scene while describing it, while a listener often imagines that scene as it’s described to her. I argue that getting clear on imagery’s psychological roles in testimonial belief transmission has implications for some fundamental issues in the epistemology of testimony. I first appeal to imagery cases to argue against a widespread ‘internalist’ approach to the epistemology of testimony. I then appeal to the same sort of case to argue for an alternative, externalist view.
Effect of the Announcement of Human-to-Human Transmission on Telemedicine Services in China During COVID-19
Authors: Maimaitiming Mairehaba , Xie Jingui , Zheng Zhichao , Zhu Yongjian 
Published: December 2022

Abstract

Objectives:
Telemedicine enables patients to communicate with physicians effectively, especially during the coronavirus disease (COVID-19) pandemic. However, few studies have explored the use of online health care platforms for a comprehensive range of specialties during the COVID-19 pandemic. This study aimed to investigate how telemedicine services were affected by the announcement of human-to-human transmission in China.

Methods:
Telemedicine data from haodf.com in China were collected. A difference-in-differences analysis compared the number of telemedicine use and the number of active online physicians for different specialties in 2020 with the numbers in 2019, before and after the announcement of human-to-human transmission.

Results:
Data from 2 473 734 telemedicine use during the same calendar time in 2020 and 2019 were collected. Telemedicine use in 2020 increased by 349.9% after the announcement of human-to-human transmission in China, and the number of active online physicians increased by 23.2%. The difference-in-differences analysis indicated that the announcement had statistically significant positive effects on the numbers of telemedicine use for almost all specialties, except cosmetic dermatology, pathology, occupational diseases, sports medicine, burn, medical imaging, and interventional medicine.

Conclusion:
Telemedicine services increased significantly after the announcement of human-to-human transmission of COVID-19. Online activities of most specialties increased, except where providers had to conduct in-person testing and provide bedside therapies.
Comorbid posttraumatic stress disorder and alcohol use disorder in low- and middle-income countries: A narrative review
Authors: Kaysen Debra L. , van Stolk-Cooke Katherine , Kaminer Debra , Greene M. Claire , López-Castro Teresa , Kane Jeremy C. 
Published: December 2022

Abstract
Much of the research on posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) has been conducted in high-income countries (HICs). However, PTSD and AUD commonly co-occur (PTSD + AUD) are both associated with high global burden of disease, and disproportionately impact those in low- and middle-income countries (LMICs). This narrative review attempts to synthesize the research on prevalence, impact, etiological models, and treatment of PTSD + AUD drawing from research conducted in HICs and discussing the research that has been conducted to date in LMICs. The review also discusses overall limitations in the field, including a lack of research on PTSD + AUD outside of HICs, issues with measurement of key constructs, and limitations in sampling strategies across comorbidity studies. Future directions are discussed, including a need for rigorous research studies conducted in LMICs that focus on both etiological mechanisms and on treatment approaches.