bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Altrazeal transforming powder dressing on stage 2–4 pressure ulcers: a clinical case series
Authors: Yu Shin Young , Ullrich Peter J , Weissman Joshua P , Joshi Chitang J , Taylor Reagan , Patel Anooj , El Hoseny Safwat , Galiano Robert D 
Published: May 2022

Objective:Pressure ulcers (PUs) are hard-to-heal, open wounds that affect millions of adults worldwide. Patients experience physical, mental, social and financial impairment. On average, <50% of stage 3 and 4 PUs heal by the sixth month. Treatment of PUs is highly variable due to a patient's comorbidities, demographics and wound characteristics. Because of this, there exists no standard dressing for PUs. Altrazeal transforming powder dressing (TPD, Uluru Inc., US) offers a promising new form of wound treatment; however, little evidence exists for TPD in the treatment of hard-to-heal PUs. This case series sought to examine the effect of TPD in hard-to-heal PUs that have previously undergone unsuccessful standard of care (SoC) wound therapy.Methods:This case series used retrospective data from patients with stage 2–4 PUs that failed to heal after SoC therapies. Factors examined were: number of dressing changes; time between dressing changes; time to wound closure; and pain level. While data were assessed for all patients, we focused on the six particular cases that most clearly illustrated the effect of TPD on wound healing.Results:Each of the 21 patients treated with TPD experienced successful and expedited wound closure. Stage 4 PUs took an average of 87 days with approximately six dressing changes to closure. Stage 3 PUs took an average of 41 days with approximately four dressing changes, and stage 2 PUs an average of 13 days to closure with approximately one dressing change. In the cases presented herein for which pain scores were reported, each showed a reduction in pain from an 8 or 9/10 to a 1 or 2/10 with the first dressing change.Conclusion:In this case series, TPD effectively reduced pain and healed PUs that had previously failed SoC interventions. We suggest future prospective studies in order to more effectively measure the wound healing capability and healthcare utilisation of TPD for treatment of PUs.
Measurement of stress-induced birefringence in a thin-disk laser with
full-Stokes polarimetry
Authors: Dominik Johanna , Scharun Michael , Dannecker Benjamin , Bühner Veronika , Ertel Klaus , Bauer Dominik , Dekorsy Thomas 
Published: May 2022

Stress-induced birefringence leads to losses in solid-state laser resonators and
amplifiers with polarized output beams. A model of stress-induced
birefringence in thin disks is presented, as well as measurements of
stress-induced birefringence in a thin disk in a multi-kilowatt
oscillator. A full-Stokes imaging polarimeter was developed to enable
fast and accurate polarimetric measurements. Experimental and
simulated results are in good agreement qualitatively and
quantitatively and show that the polarization loss due to
stress-induced birefringence is negligible for ytterbium-doped thin
disks with a thickness around 100 µm but becomes relevant in thicker
disks. It is concluded that stress-induced birefringence should be
taken into consideration when designing a thin-disk laser system.
C-band 67 GHz silicon photonic microring modulator for dispersion-uncompensated 100 Gbaud PAM-4
Authors: Chan David W. U , Wu Xiong , Zhang Zunyue , Lu Chao , Lau Alan Pak Tao , Tsang Hon Ki 
Published: May 2022

A very-high-bandwidth integrated silicon microring modulator (MRM) designed on a commercial silicon photonics (SiP) platform for C-band operation is presented. The MRM has a 3 dB electro-optic (EO) bandwidth of over 67 GHz and features a small footprint of 24 µm × 70 µm. Using the MRM, we demonstrate intensity modulation–direct detection (IM-DD) transmission with 4-level pulse amplitude modulation (PAM-4) signaling of over 100 Gbaud. By utilizing the optical peaking effect and negative chirp in the MRM, we extend the transmission distance, which is limited by the fiber-dispersion-induced frequency fading. Using a standard single-mode fiber (SSMF) for transmission across distances of up to 2 km, we measured the data transmission of 100 Gbaud PAM-4 signals with a bit error rate (BER) under the general 7% hard-decision forward-error correction (HD-FEC) threshold. The MRM enables an extended transmission distance for 100 Gbaud signaling in the C-band without dispersion compensation.
Translation model for CW chord to angle Alpha derived from a Monte-Carlo simulation based on raytracing
Authors: Langenbucher Achim , Szentmáry Nóra , Cayless Alan , Weisensee Johannes , Wendelstein Jascha , Hoffmann Peter 
Published: May 2022

Background
The Chang-Waring chord is provided by many ophthalmic instruments, but proper interpretation of this chord for use in centring refractive procedures at the cornea is not fully understood. The purpose of this study is to develop a strategy for translating the Chang-Waring chord (position of pupil centre relative to the Purkinje reflex PI) into angle Alpha using raytracing techniques.

Methods
The retrospective analysis was based on a large dataset of 8959 measurements of 8959 eyes from 1 clinical centre, using the Casia2 anterior segment tomographer. An optical model based on: corneal front and back surface radius Ra and Rp, asphericities Qa and Qp, corneal thickness CCT, anterior chamber depth ACD, and pupil centre position (X-Y position: PupX and PupY), was defined for each measurement. Using raytracing rays with an incident angle IX and IY the CW chord (CWX and CWY) was calculated. Using these data, a multivariable linear model was built up in terms of a Monte-Carlo simulation for a simple translation of incident ray angle to CW chord.

Results
Raytracing allows for calculation of the CW chord CWX/CWY from biometric measures and the incident ray angle IX/IY. In our dataset mean values of CWX = 0.32±0.30 mm and CWY = -0.10±0.26 mm were derived for a mean incident ray angle (angle Alpha) of IX = -5.02±1.77° and IY = 0.01±1.47°. The raytracing results could be modelled with a linear multivariable model, and the effect sizes for the prediction model for CWX are identified as Ra, Qa, Rp, CCT, ACD, PupX, PupY, IX, and for CWY they are Ra, Rp, PupY, and IY.

Conclusion
Today the CW chord can be directly measured with any biometer, topographer or tomographer. If biometric measures of Ra, Qa, Rp, CCT, ACD, PupX, PupY are available in addition to the CW chord components CWX and CWY, a prediction of angle Alpha is possible using a simple matrix operation.
A national study of moral distress among U.S. internal medicine physicians during the COVID-19 pandemic
Authors: Sonis Jeffrey , Pathman Donald E. , Read Susan , Gaynes Bradley N. 
Published: May 2022

Background
There have been no studies to date of moral distress during the COVID-19 pandemic in national samples of U.S. health workers. The purpose of this study was to determine, in a national sample of internal medicine physicians (internists) in the U.S.: 1) the intensity of moral distress; 2) the predictors of moral distress; 3) the outcomes of moral distress.

Methods
We conducted a national survey with an online panel of internists, representative of the membership of the American College of Physicians, the largest specialty organization of physicians in the United States, between September 21 and October 8, 2020. Moral distress was measured with the Moral Distress Thermometer, a one-item scale with a range of 0 (“none”) to 10 (“worst possible”). Outcomes were measured with short screening scales.

Results
The response rate was 37.8% (N = 810). Moral distress intensity was low (mean score = 2.4, 95% CI, 2.2–2.6); however, 13.3% (95% CI, 12.1% - 14.5%) had a moral distress score greater than or equal to 6 (“distressing”). In multiple linear regression models, perceived risk of death if infected with COVID-19 was the strongest predictor of higher moral distress (β (standardized regression coefficient) = 0.26, p < .001), and higher perceived organizational support (respondent belief that their health organization valued them) was most strongly associated with lower moral distress (β = -0.22, p < .001). Controlling for other factors, high levels of moral distress, but not low levels, were strongly associated (adjusted odds ratios 3.0 to 11.5) with screening positive for anxiety, depression, posttraumatic stress disorder, burnout, and intention to leave patient care.

Conclusions
The intensity of moral distress among U.S. internists was low overall. However, the 13% with high levels of moral distress had very high odds of adverse mental health outcomes. Organizational support may lower moral distress and thereby prevent adverse mental health outcomes.
Limited dose-dependent effects of vedolizumab on various leukocyte subsets
Authors: Becker Emily , Schweda Anna , Ullrich Karen A.-M. , Voskens Caroline , Atreya Raja , Müller Tanja M. , Atreya Imke , Neurath Markus F. , Zundler Sebastian 
Published: May 2022

Abstract

Background:
The anti-α4β7 integrin antibody vedolizumab (VDZ) is successfully used for the treatment of inflammatory bowel diseases (IBD). However, only a subgroup of patients respond to therapy. Vedolizumab is administered at a fixed dose, leading to a wide range of serum concentrations in patients. Previous work from our group showed a dose-dependent preferential binding of vedolizumab to effector compared to regulatory CD4+ T cells. Therefore, we aimed to determine the dose-dependent binding profile of vedolizumab to other leukocyte subsets.

Methods:
We characterised α4β7 integrin expression on CD8+ T cells, CD19+ B cells, CD14+ monocytes, natural killer (NK) cells and eosinophils from IBD patients and healthy controls. We studied the binding of vedolizumab to these cells at different concentrations and investigated the functional consequences for dynamic adhesion and transmigration in vitro.

Results:
The expression of α4β7 differed between the analysed leukocyte subsets and was significantly higher on eosinophils from patients compared to controls. Almost all α4β7-expressing cells from these subsets were bound by vedolizumab at a concentration of 10 µg/ml. Dynamic cell adhesion was significantly impaired in all subsets, but there were no dose-dependent differences in the inhibition of adhesion.

Discussion:
Our data suggest that α4β7-expressing CD8+ T cells, CD19+ B cells, CD14+ monocytes, NK cells and eosinophils are a target of vedolizumab. However, there do not seem to be concentration-dependent differences regarding the effects on these cells in the clinically relevant range. Thus, the reported exposure efficacy characteristic of vedolizumab can probably mainly be attributed to CD4+ T cell subsets.
Frontal-occipital network alterations while viewing 2D & 3D movies: a source-level EEG and graph theory approach
Authors: Yu Minchang , Xiao Shasha , Tian Feng , Li Yingjie 
Published: May 2022

Abstract
Many researchers have measured the differences in electroencephalography (EEG) while viewing 2D and 3D movies to uncover the neuromechanism underlying distinct viewing experiences. Using whole-brain network analyses of scalp EEG, our previous study reported that beta and gamma bands presented higher global efficiencies while viewing 3D movies. However, scalp EEG is influenced by volume conduction, not allowing inference from a neuroanatomy perspective; thus, source reconstruction techniques are recommended. This paper is the first to measure the differences in the frontal-occipital networks in EEG source space during 2D and 3D movie viewing. EEG recordings from 40 subjects were performed during 2D and 3D movie viewing. We constructed frontal-occipital networks of alpha, beta, and gamma bands in EEG source space and analyzed network efficiencies. We found that the beta band exhibited higher global efficiency in 3D movie viewing than in 2D movie viewing; however, the alpha global efficiency was not statistically significant. In addition, a support vector machine (SVM) classifier, taking functional connectivities as classification features, was built to identify whether the frontal-occipital networks contain patterns that could distinguish 2D and 3D movie viewing. Using the 6 most important functional connectivity features of the beta band, we obtained the best accuracy of 0.933. Our findings shed light on uncovering the neuromechanism underlying distinct experiences while viewing 2D and 3D movies.
BiSHM: Evidence detection and preservation model for cloud forensics
Authors: Purnaye Prasad , Kulkarni Vrushali 
Published: May 2022

Abstract
The cloud market is growing every day. So are cloud crimes. To investigate crimes that happen in a cloud environment, an investigation is carried out adhering to the court of law. Forensics investigations require evidence from the cloud. Evidence acquisition in the cloud requires formidable efforts because of physical inaccessibility and the lack of cloud forensics tools. Time is very crucial in any forensic investigation. If the evidence is preserved before the cloud forensic investigation, it can give the investigators a head start. To identify and preserve such potential evidence in the cloud, we propose a system with an artificial intelligence (AI)-based agent, equipped for binary classification that monitors and profiles the virtual machine (VM) from hypervisor level activities. The proposed system classifies and preserves evidence data generated in the cloud. The evidence repository module of the system uses a novel blockchain model approach to maintain the data provenance. The proposed system works at the hypervisor level, which makes it robust for anti-forensics techniques in the cloud. The proposed system identifies potential evidence reducing the effective storage space requirement of the evidence repository. Data provenance incorporated in the proposed system reduces trust dependencies on the cloud service provider (CSP).
Phase field modeling of corrosion damage
Authors: Imanian Anahita , Amiri Mehdi 
Published: May 2022

Abstract
A phase field (PF) based electrochemical model is presented for simulation of galvanic corrosion. Distributions of electrolyte potential and current density on anode and cathode surfaces are obtained by coupling the PF variable with electrochemistry. Evolution of surface recession is naturally obtained by solving the PF equations without tracking the evolving boundary. Numerical implementation involves solving the governing equations on a fixed mesh. The sharp interface as the limit of the PF model is shown by an asymptotic analysis. Two benchmark problems are discussed: a magnesium alloy–mild steel couple exposed to 5% NaCl solution and crevice corrosion for nickel in 1 N sulfuric acid. A comparison is made considering available experimental data as well as other simulation data by an arbitrary Lagrangian–Eulerian method. Good agreement is obtained.
Las metáforas temporales tiempo como movimiento de/por un lugar y tiempo como movimiento de arriba abajo y sus realizaciones en la lengua española
Authors: Huelva Unternbäumen Enrique 
Published: May 2022

Resumen
En este trabajo nos proponemos analizar las metáforas temporales tiempo como movimiento de/por un lugar y tiempo como movimiento de arriba abajo y sus realizaciones en la lengua española. Mostraremos que la primera debe ser considerada una metáfora central, tan importante para conceptuar la temporalidad como las metáforas tiempo es movimiento del sujeto y tiempo es movimiento del objeto, tradicionalmente consideradas en los estudios sobre metáfora. La segunda, por su parte, es una metáfora secundaria que complementa a las principales al especializarse en la expresión de la imprevisibilidad del tiempo. El trabajo aporta también el postulado de un conjunto de parámetros y principios metodológicos para la descripción y clasificación de metáforas temporales.
Pervivencia del discurso colonial y fijación de fetiches raciales y culturales en la literatura argentina de la postindependencia: la generación literaria de 1837
Authors: Kruse Elisabeth 
Published: May 2022

ResumenEl presente artículo aborda la pervivencia y acentuación del discurso colonial más allá de la Independencia americana, a través del análisis de la literatura de la generación romántica argentina de los escritores de 1837, quienes, como políticos, diseñaron un proyecto de nación progresista, europeizante y discriminatoria, sustentado por ideas pseudo-científicas deterministas. Se analizan sus discursos en la poesía y ensayos, a la luz del concepto de “ficciones orientadoras” de N. Shumway así como de postulados de los estudios poscoloniales de H. Bhabha y W. Mignolo. De este modo se intenta revisar y cuestionar el modo de representar la alteridad, tema fundamental en la manera de abordar la literatura desde los Estudios Culturales.
Bec(h)oming with Simon Whitehead: Practising a Logic of Sensation
Authors: Lavery Carl 
Published: May 2022

Abstract
In this text and image essay, I introduce a new concept to the environmental humanities; one which seeks to trouble metaphysical notions of dwelling by combining the idea of home (the oikos in ecology) with a notion of permanent becoming. In this way, home loses its conservative and reactionary connotations with atavistic origins and identities and instead is opened up to nonhuman forces and powers. As I explain in the opening section, bec(h)oming is a matter of affect; it depends upon the capacity of bodies to move beyond themselves, to be impressed and transformed by the environments which they move through, to tap what the philosopher Gilbert Simondon might see as the “pre-individual” energy that runs through all organisms. Humans are no exception; they, too, are caught in the flux and flow. By focusing on bodies, the essay not only looks to depart from conventional narrative-based notions of ecocriticism and theatre ecology, it aims to provide a lexicon, a new idiom for thinking through corporeal ecologies that are attuned to sensations, the virtual play of a cosmic Earth. To do that, the text provides the first detailed account of the work and practices of influential UK movement artist Simon Whitehead, whose Locator workshop has proved pivotal for so many dancers, choreographers, and artists over the past few decades. Integral to the paper is a desire to experiment with alternative modes of writing, a style that would express the enthusiasms of bec(h)omings and give some sense of its somatic potential.
An Art Like Nature: Theatre Environment as Territory in Tim Spooner Performances
Authors: Bowes Simon 
Published: May 2022

Abstract
Tim Spooner has described his practice as “an increasingly complex series of live performances centred on the revelation of life in material.”1 In this article, I consider this revelation as the precondition of a theatre ecology. Spooner stages a theatrical encounter between bodies and environments, in which distinctions between person-thing, subject-object, self-other no longer hold. Whilst there are evident parallels between this practice and posthumanist, or new-materialist philosophy, I shall describe Spooner’s theatre as artlike.This article responds to two thematics outlined in the original call for papers for CDE 2021: “eco-spaces” and “eco-aesthetics.” The argument runs: 1) an ecological space is the result of an ecological aesthetics; theatre is considered fundamentally social, political in significance; art is fundamentally ecological in significance; 2) ecocritical theatre and theatre ecology are categorically distinct: in ecocriticism, political, social, and cultural concerns mediate a concern for nature; in a theatre ecology nature is reconstructed virtually; 3) ecocriticism stages a recognition of an ecological crisis in social terms; theatre ecology stages a revelation of an environment; 4) against theatre, there is legislation; 5) a theatre ecology extends a juxtapositional logic of political ecology: this is a false start and ill-timed.The argument leads to a reconstruction of three gestures drawn from three of Spooner’s performances. In these gestures, theatre is rendered artlike. The exposition describes Spooner’s practice in terms of embodiment and occupation, before considering how the ecological implications of an artlike theatre are, firstly and finally, ethical.
Encounters in the Chthulucene: Simon McBurney’s Theatre of Compost
Authors: Ayache Solange 
Published: May 2022

Abstract
Looking at Simon McBurney’s award-winning solo performance The Encounter (2015), this paper examines the play’s contribution to environmental humanities through an ecocritical study of its combined use of state-of-the-art sound design and the age-old art of storytelling to address the link between the ecological and spiritual crises that we are facing. The Encounter relates the real story of the American photographer Loren McIntyre who lived with the Mayoruna tribe for six weeks in 1969 after getting lost in the Amazon rainforest. Relying heavily on sound design to take us deep into the jungle, the show addresses our relation to nature and technology and elicits our empathy to denounce the dictates of a globalised world ruled and threatened by neoliberal and neocolonial capitalistic ideologies. As the brain – and the stage – become the forest, The Encounter challenges the notions of distance and separation from the Other in favour of a deep sense of interconnectedness. Using Donna J. Haraway’s 2016 book Staying with the Trouble: Making Kin in the Chthulucene, this article sheds light on how The Encounter invites us to recognise the urgency of defining what it means to live together in “response-ability on a damaged earth” (Haraway 2) and how the intermedial, hybrid qualities of the play found not a “post-human” but, on the contrary, a “com-post” theatre piece (11).
To Be Like Water: Material Dramaturgies in Posthumanist Performance
Authors: Mosse Ramona , Street Anna 
Published: May 2022

Abstract
This article explores how water performs on the contemporary stage. Drawing on theorists such as Rosi Braidotti, Karen Barad, and Joanna Zylinska, we investigate water in its various dramaturgical functions as matter, medium, and metaphor to sketch performance alternatives that highlight nonhuman forms of agency. Focusing on the work of sound artist and geographer AM Kanngieser and their use of water to listen to the Anthropocene as well as on the Filter Theatre production of David Farr’s play Water (2007/2013), we want to highlight how diffraction and resonance alternately provide ways of rethinking traditional configurations of making meaning. The sonic dimension of water, in particular, turns into a productive site for manifesting the heightened relationality of the Anthropocene world. The article thus argues that the material dramaturgies of water show how the crucial interactions between science, philosophy, and performance manage to sketch new posthuman knowledge formations.
An Ecology of Plants: The Post-Manufacturing Age in Philip Ridley’s Shivered and David Eldridge’s In Basildon
Authors: Attinger Christian 
Published: May 2022

Abstract
The article argues that the so-called Capitalocene, proposed by Jason W. Moore, augments Anthropocenic reasoning by addressing the systemic and ideological shortcomings threatening the very basics of human existence that hitherto have so often been neglected or simply missed by “Green Arithmetic” and a naive belief in technology. The readings of Philip Ridley’s Shivered (2012) and David Eldridge’s In Basildon (2012) illustrate that the Capitalocene and its attempts at understanding the ecological and social consequences of global capitalism offer an exciting new lens for the analysis of contemporary political drama, especially with regard to the ecology of industrial plants in the post-manufacturing age.