bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Constitutional and Legal Regulation of Science
Authors: Atabekova N. K. 
Published: April 2022

The sphere of science is one of the important spheres of economic development ensuring the effective functioning of the state. Science has a direct impact on the pace and direction of economic development, thus, it can contribute to improving the socio-economic condition of the citizens. Therefore, science requires the attention of the state at the highest level. In this aspect, the constitutional and legal regulation of relations in the field of science plays an essential role, determining the priorities of state building.The purpose of this work is to study the specifics of the constitutional and legal regulation of the sphere of science in modern states and to identify the features of the national constitutional legislation of the Kyrgyz Republic in the light of the constitutional reform carried out on April 11, 2021. In the course of the study, a comparative historical method was used, which made it possible to consider the problems in retrospect. The use of the statistical method demonstrated the peculiarities of state support for science in various countries. The comparative legal method contributed to the comparative analysis of the constitutional and legal regulation of the sphere of science in a number of foreign countries and the reflection of the general and specific in this matter, which allowed us to develop practical recommendations for improving domestic constitutional legislation.The author summarizes that the states claiming leadership in science and education in the global context understand that these areas form the basis of the post-industrial innovation economy, and, therefore, define them as priorities in state building. This is expressed, firstly, in the constitutional consolidation of the state policy in the field of science and education; secondly, in the institutional support of the sphere of science; and thirdly, in sufficient funding of the sphere of science. Constitutional and legal norms presuppose the development of a mechanism for their implementation. In this aspect, one of the important conditions for their implementation are financial and economic guarantees, which, unfortunately, remain insufficient in Kyrgyzstan, which causes low rates of development of domestic science and insufficient representation of its results on the world stage.
Pengetahuan sikap dan perilaku berhubungan dengan infeksi COVID-19 pada petugas rumah sakit
Authors: Nadila Niken , Kartini Kartini 
Published: April 2022

LATAR BELAKANG
Kasus COVID-19 di Indonesia semakin meningkat dan banyak petugas rumah sakit yang terinfeksi COVID-19, untuk itu diperlukan pengetahuan, sikap dan perilaku yang baik dari petugas rumah sakit agar tidak terinfeksi COVID-19. Penelitian ini bertujuan menilai hubungan pengetahuan, sikap dan perilaku dengan infeksi COVID-19 pada petugas rumah sakit.
METODE
Desain penelitian adalah observasional analitik dengan pendekatan potong lintang (cross sectional). Subyek penelitian adalah petugas rumah sakit dengan sampel sebanyak 200 responden memenuhi kriteria inklusi dan eksklusi. Pengumpulan data menggunakan kuesioner pengetahuan, sikap dan perilaku dalam menghadapi COVID-19 dan riwayat terinfeksi COVID-19, dikumpulkan melalui google form. Uji hipotesis dengan menggunakan uji Chi-square/Fisher’s Exact dengan tingkat kemaknaan p<0,05.
HASIL
Hasil penelitian menunjukkan mayoritas pengetahuan responden baik (66%), sikap responden positif (69%), dan perilaku responden positif (95,5%), sebagian besar responden tidak terinfeksi COVID-19 (87,5%). Analisa dengan menggunakan uji Chi-Square menunjukkan terdapat hubungan yang bermakna antara pengetahuan (p=0,007), sikap (p=0,002), dan perilaku (p=0,000) dengan infeksi COVID-19.
KESIMPULAN
Pengetahuan, sikap dan perilaku berhubungan dengan infeksi COVID-19 pada petugas rumah sakit.
Outcome of early control of infection using antibiotics impregnated cement beads in early surgical site infection in operated case of intra articular comminuted fracture (AO C3) of distal femur with ORIF: case report and review of literature
Authors: Chaudhari Kunal , Mahajan Neetin P. , Sangma Sunny , Jarika Ashish Kumar , Talukderg Pritam 
Published: April 2022

<p class="abstract">Surgical site infection is the most deleterious complication for any surgery and it's quite a daunting task for the surgeon to manage such post op events which also takes a great toll on patients' health physically as well as financially. Here we are presenting one such case report of early SSI effectively managed with antibiotic cement beads incorporation locally. We report a 65 year old male patient case of left sided comminuted distal femur fracture who was managed operatively with open reduction and internal fixation with 8 holes distal femur plate. Patient developed early SSI and was managed with debridement and antibiotic cement beads which was removed 6 weeks later. Here, we bring to the fore relevant findings to conclude the advantages of antibiotic cement beads for infected surgical wounds. In our case, early intervention resulted in full recovery of the patient from surgical site infection, early rehabilitation of joint mobility, decreased hospital stay and expenses. Looking at the advantages it is concluded from our study that locally impregnated antibiotic beads confers higher effectivity, compliance and cost benefits to the patient. </p>
First Report of a Derivative Chromosome 13 with a Duplicated 11p15 Locus Associated with Silver-Russell syndrome
Authors: Hamza Nishath , Al-Araimi Musallam , Al Salmani Kamla , Al Obeidani Salwa 
Published: April 2022

Silver-Russell Syndrome (SRS) is a disorder that is primarily characterized by intrauterine growth restriction which may occur asymmetrically or in whole, leading to a fetus being small relative to its gestational age. We present a female infant (proband), with severe congenital anomalies. The proband carried a >25Mb duplication of the chromosomal 11p15-11pter locus of chromosome 13; creating a derivative chromosome 13 [der(13)] and was reported as 46,XX,der(13)add(11p15-11pter). A methylation-sensitive assay confirmed a diagnosis of Silver-Russell Syndrome (SRS). Although the prognosis for SRS patients is generally good, our proband presented with a clinically severe phenotype culminating in death at nine months. To the best of our knowledge, this is the first report of a derivative chromosome 13 with a duplicated 11p15 locus being reported in a patient with SRS.
Keywords: Silver-Russell syndrome, growth retardation, imprinting, derivative chromosome.
The Role of Motivation in Mediating the Influence of Career Development on Employee Performance
Authors: Fauziyana Evi , Wijayanti Wardoyo Dewie Tri , Witjaksono Andre Dwijanto 
Published: April 2022

This study was designed to determine the factors that affect employees' performance. The problem is the role of motivation in mediating the effect of career development on employee performance at PT. PLN (Persero) UP3 Bojonegoro Area. Research on motivation in mediating the effect of career development on employee performance at PT. PLN (Persero) UP3 Bojonegoro. The research uses quantitative methods; the population is employees at PT. PLN (Persero) UP3 Bojonegoro area as many as 135 people. The research sample was determined by accidental sampling and calculated using the Slovin formula, a sample of 57 people. The data analysis used in this research is PLS (Partial Least Square) analysis. The result is that career development has a positive effect on employee performance, career development positively affects motivation, and motivation has a positive effect on employee performance.
Makna Tari Sada-Sabai Dalam Upacara Pernikahan Masyarakat Komering Martapura, OKU Timur
Authors: Pebriyanti Indah 
Published: April 2022

Indonesia merupakan salah satu Negara dengan banyak ragam budaya maupun adat istiadat didalamnya. Salah satunya, Tari Sada Sabay yang merupakan salah satu tarian khas Suku Komering yang ada di Kabupaten Ogan Komering Ulu Timur, Sumatera Selatan. Tarian ini dilaksanakan ketika upacara pernikahan berlangsung, tarian ini tidak hanya dilakukan ketika sesama suku Komering yang menikah. Tari Sada Sabay tetap dilaksanakan dalam tiga kondisi pernikahan yakni perempuan suku Komering dengan laki-laki suku Komering, perempuan suku Komering dengan laki-laki bukan suku Komering, dan perempuan bukan suku Komering dengan laki-laki suku Komering. Tari Sada Sabay ini dilakukan pada saat acara inti dari upacara pernikahan berlangsung, tari ini dilakukan oleh kedua orang tua mempelai pengantin dan posisi pengantin dibelakang mertua masing-masing dengan posisi mengipas ke arah mertua mereka. Tari Sada Sabay ini dimaknai sebagai tari kekelurgaan, tari kebahagiaan, serta wujud rasa syukur telah mendapatkan keluarga baru dari pernikahan anak-anak mereka. Diketahui tarian ini telah dilaksanakan sejak zaman nenek moyang suku Komering terdahulu, hanya saja mengalami perubahan pada musik pengiringnya. Dahulu musik pengiring dari tarian ini masih berupa alat musik tradisional yang bernama Kulintang, seiring perkembangan zaman tari Sada Sabay ini dilakukan dengan iringan musik orgen tunggal tetapi masih ada dibeberapa tempat yang melaksanakan tari Sada Sabay ini dengan iringan musik tradisional Kulintang.
PROTOTYPE ALAT FERMENTOR STATER MODIFIED CASSAVA FLOUR MENGGUNAKAN METODE FUZZY MAMDANI
Authors: Widjonarko Widjonarko , Sumardi Sumardi , Anam Khairul , Cahyani Sherly Mutiara 
Published: April 2022

Stater MOCAF is a seed fermented during the manufacture of biologically modified MOCAF. The manufacture of MOCAF stater tools can help MOCAF flour entrepreneurs to use automated tools in producing staters. The design used the Arduino Mega2560 as a microcontroller to control the fermentation tank system. Temperature parameters in the heater are used to stabilize the temperature with a set point of 370C. As for the set point pH 5.5. Use citric acid for acidic liquids, and use water pH 8+ for alkaline solutions. The bacteria used to make mocaf staters is lactobacillus plantarum.
The first test was to test the PWM PG45 motor, which is used to drive a mixer in the form of a duty cycle. Sensor testing includes DS18B20 waterproof temperature sensor testing and pH sensor testing. In addition, the Fuzzy Mamdani method is used to test the tool as a whole. This fuzzy control is used to control the temperature and pH value of the MOCAF fermentor. If the temperature and pH values do not match the required parameters, then there are temperature actuators and pH actuators to stabilize the parameters. Fermentation is carried out for 24 hours, and the temperature and pH value are controlled to remain stable at 370C and the pH range of 4-6. After about 4 hours of measurement, the new temperature drops. However, after 10 minutes, the temperature stabilizes at 370C. As for the pH value, because the pH sensor reading response is about 2 minutes then the value will change.
Perancangan Ikat Pinggang Pendeteksi Halangan untuk Tunanetra dengan Metode Half Cylinder Berbasis Single Board Microcontroller Bertenaga Panel Surya
Authors: Pradana Adlan Bagus , Wibowo Muhammad Arief , Sumartopo Astri , Putra Jimmy Trio 
Published: April 2022

On this earth, not a few humans have physical deficiencies in the form of five imperfect senses, one of which is blind people. Blind
people are someone who is unable to see well because their visual system is impaired due to heredity, accidents, or other factors. In their activities, blind people need assistive devices in the form of a guidepost to find out the appropriate and safe direction of the road. However, it is not common for blind people who still have difficulty walking using manual walking sticks which are considered to have a low level of accuracy. This is then used as the main idea of ​​the research which aims to create an automatic guide in the form of an obstacle detection belt for the visually impaired using a half cylinder method based on a single board microcontroller using solar panel powered. This tool is an innovation of a manual walking stick developed by utilizing the HC-SR04 ultrasonic sensor as an obstacle detector and the Arduino nano control system by applying the half cylinder method to the area of ​​catching the reflected obstruction waves. The reflected waves captured by the HC-SR04 ultrasonic sensor are then converted into distance units to determine the output of the DC motor and buzzer.

Keywords — blind people, walking stick, obstacle detection belt.
Studi Peramalan Beban PT. PLN (PERSERO) APJ Jember dengan Menggunakan Metode Backward Propagation Neural Network dan Teknik Participatory Prospective Analysis
Authors: Kurniadi Wahyu Septiyan , Kaloko Bambang Sri , Hardianto Triwahju 
Published: April 2022

Abstrak
Diperlukannya suatu sistem peramalan yang akurat sangat dibutuhkan dalam perencanaan pertumbuhan energi listrik di Indonesia yang mayoritas pembangkitan energi listrik masih menggunakan bahan bakar fosil dengan total 85,05% dari keseluruhan energi yang dihasilkan hingga Mei 2020. Dengan peramalan dapat diketahui kapan waktu yang tepat untuk penambahan kapasitas dari jaringan transmisi, distribusi dan sistem pembangkitan energi listrik. Pertumbuhan energi listrik di Indonesia juga dipengaruhi oleh pertumbuhan penduduk dan perekonomian. Untuk mengetahui pertumbuhan beban di Kabupaten Jember digunakan jaringan saraf tiruan dengan metode Backward Propagation Neural Network dan teknik Participatory Propective Analysis yang menggunakan variabel berupa pertumbuhan penduduk dan pertumbuhan perekonomian Kabupaten Jember. Adapun didapat dari hasil pelatiha berupa nilai error sistem sebesar 0.0098012% dengan nilai Mean Absolute Percentage Error (MAPE) sebesar 2,649% dimana nilai error terkecil sebesar -0.00372% pada bulan Mei 2020 dan nilai error terbesar sebesar 20.189% pada bulan Oktober 2018. Didapat juga hasil peramalan beban pada tahun 2021 dari bulan Januari 2021 sampai dengan bulan Mei 2021 dengan nilai error total sebesar 19,2% dengan selisih beban terbesar pada bulan Januari sebesar 51.177.681,23 Watt dan terkecil pada bulan Mei sebesar 5.832.254,501 Watt.

Kata Kunci — Backward Propagation Neural Network, Participatory Prospective Analysis, Pertumbuhan Energi Listrik.

Abstract
The need for an accurate forecasting system is urgently needed in planning the growth of electrical energy in Indonesia, where the majority of electrical energy generation still uses fossil fuel with a total of 85.05% of the total energy produced until May 2020. With forecasting it can be known when the right time is to increase capacity of the transmission, distribution and generation system of electrical energy. The growth of electrical energy in Indonesia is also influenced by population and economic growth. To determine the load growth in Jember Regency, an artificial neural network is used with the Backward Propagation Neural Network method and the Participatory Prospective Analysis technique that uses variables in the form of population growth and economic growth in Jember Regency. As for the results obtained from the training in the form of a system error value of 0.0098012% with a Mean Absolute Percentage Error (MAPE) value of 2.649% where the smallest error value is -0.00372% in May 2020 and the largest error value is 20.189% in October 2018. Also obtained the results of load forecasting in 2021 from January 2021 to May 2021 with a total error value of 19.2% with the largest load difference in January of 51,177,681.23 Watts and the smallest in May of 5,832,254,501 Watts.

Keywords — Backward Propagation Neural Network, Electrical Energy Growth, Participatory Prospective Analysis.
Causas denominativas na categoria dos cronotopônimos
Authors: Ananias Anna Carolina Chierotti dos Santos , Tavares Marilze 
Published: April 2022

Em estudos da toponímia brasileira, um dos procedimentos mais utilizados pelos pesquisadores quanto à análise dos nomes geográficos é a aplicação de um modelo taxionômico. O modelo de Dick (1990b), que tem como objetivo a classificação dos elementos motivadores de forma objetiva e de uma perspectiva sincrônica, inclui, por exemplo, a categoria dos crononotopônimos – topônimos com indicadores cronológicos representados pelos adjetivos novo(a) e velho(a). Quando se deseja evidenciar as causas específicas – que envolvem as razões do denominador – é necessário o levantamento de pelos menos alguns aspectos da história do acidente geográfico nomeado, isto é, a perspectiva passa a ser diacrônica. O objetivo do estudo apresentado neste texto é demonstrar que em uma mesma categoria, as causas denominativas, apesar de específicas para cada designativo, podem ser sistematizadas e divididas em grupos conforme seu conteúdo semântico. Para isso, toma-se a lista de nomes de municípios brasileiros disponibilizada pelo IBGE e separam-se os 137 considerados cronotopônimos; na sequência, investigam-se aspectos da história de cada município (especialmente a partir do Portal Cidades@ do IBGE e dos sites oficiais de cada município). No que se refere às reflexões teóricas, parte-se dos estudos de Lognon (1920), Dauzat (1947) e Dick (1990a, 1990b, 1999). A pesquisa evidenciou como principais causas denominativas dos cronotopônimos as seguintes: a) um aglomerado humano já nomeado, após atos administrativos, passa à categoria de município e inclui o adjetivo novo(a) para marcar um outro momento da história do seu desenvolvimento; b) o município recebe o nome em referência a outra cidade, estado, país etc. e, para evitar a homonímia de topônimos, inclui-se o adjetivo novo(a). Além dessas, outras causas denominativas estão descritas no artigo.
Eclampsia as the leading cause of maternal death at Prof. dr. R.D. Kandou Hospital, Manado, Indonesia
Authors: Tendean Hermie Meety Maasje , Sondakh Joice Margaretha Mathilda , Lumentut Anastasia Mariane , Ibrahim Reni Christiani 
Published: April 2022

HIGHLIGHTS
1. One indicator of progress in a country's health is maternal mortality rate.2. The characteristics of maternal mortality were examined in a regional hospital in North Sulawesi, Indonesia3. Eclampsia was found to provide the most contribution to maternal mortality cases in the hospital.

ABSTRACT
Objectives: To determine the characteristics of maternal deaths at Prof. dr. R.D. Kandou Hospital, Manado, Indonesia, from January 1 to December 31, 2019.
Materials and Methods: This was a retrospective descriptive study. Data were taken from the patient's medical record at Prof. dr. R.D. Kandou Hospital, Manado, in the period of January 1, to December 31, 2019.
Results: From January 1 to December 31, 2019 in Prof. dr. R.D. Kandou Hospital, Manado, there were1.215 single live births, with maternal mortality of 22 cases. In the distribution of characteristics based on age, most patients had age range of 20-34 years with a total of 15 patients (68.18%) and parity 2 - 4 with a total of 21 patients (95,45%), Antenatal Care (ANC) of 1 – 3 times visit in a total of 11 cases (50%), and most came from outside the city of Manado with a total of 12 patients (54.54%). The most common cause of maternal death was due to eclampsia, comprising 8 cases (36.36%).
Conclusion: Maternal death cases in Obstetrics and Gynecology Department of Prof. dr. R.D. Kandou Hospital, Manado, Indonesia, in 2019 reached 22 cases per 1.215 live births. Eclampsia was still the leading cause of maternal death.
Hot herbal compresses as therapy for reducing labor pain levels in the first stage of active phase in primigravida
Authors: Larasati Sofika , Pramono Noor , Ramlan Djamaluddin 
Published: April 2022

HIGHLIGHTS
1. Labor pain, a physiological during labor, is regared as the most severe pain experienced by women.2. Hot herbal compress was provided as a therapy for reducing labor pain level in the first stage of active phase in primigravida.3. Hot herbal compress was found to have an effect as a therapy for reducing labor pain level in the first stage of the active phase of primigravida.

ABSTRACT
Objective: To prove the effect of providing hot herbal compresses as a therapy for reducing the level of labor pain in the first stage of the active phase of primigravida
Materials and Methods: This was a true experimental study using pretest and posttest designs with control group. There was an intervention group (n=19) which was provided with hot herbal compress therapy for 20 minutes with a temperature between 37-51.5oC and a control group (n=19) receiving breathing exercise therapy. Respondents were selected by inclusion and exclusion criteria and randomization was carried out to determine whether the respondents were included in the intervention or control group by drawing lots.
Results: Hot herbal compress therapy reduced the level of labor pain in the first active phase at the 1st hour treatment by 49.3% (p=0.000), the 2nd hour by 50.3% (p=0.000), and the third hour by 22.4% (p=0.009).
Conclusion: Hot herbal compresses have an effect as a therapy for reducing pain levels of labor in the first stage of the active phase of primigravida.
Fabrication of three-dimensional lacrimal gland-like tissue organoids from human pluripotent stem cells
Authors: Okubo Toru , Hayashi Ryuhei , Kudo Yuji , Ishikawa Yuki , Quantock Andrew J. 
Published: April 2022

Abstract
We have established a method for producing three-dimensional lacrimal gland-like tissue organoids from human pluripotent stem cells (hPSCs). These resemble native lacrimal glands on the basis of their morphology, immuno-labelling characteristics and gene expression patterns. When transplanted into the connective tissue above the eyes of recipient rats the organoids undergo functional maturation, producing tear film proteins.
Induction of human pluripotent stem cells from human somatic cells by chemical reprogramming
Authors: Deng Hongkui , Guan Jingyang , Wang Guan , Wang Jinlin , Zhang Zhengyuan , Fu Yao , Cheng Lin , Meng Gaofan , Zhu Jialiang , Wang Yanglu , Liuyang Shijia , Yang Zirun , He Huanjing , Zhong Xinxing , Chen Qijing 
Published: April 2022

Abstract
Pluripotent stem cells can be induced from somatic cells by the cellular intrinsic factors, including oocyte components or transcription factors1-4. Previously, we have demonstrated that mouse pluripotent stem cells can be induced from mouse somatic cells by small molecule-based external stimulation, providing a fundamentally different approach for inducing pluripotency5-8. Here we demonstrated that human pluripotent stem cells can be induced by small molecules from human somatic cells. This protocol describes the detailed procedures for the induction of human chemically induced pluripotent stem cells (hCiPSCs) from human somatic cells. In this method, the freshly isolated human embryonic fibroblasts (HEFs), human adipose derived mesenchymal stromal cells (hADSCs), and human adult skin fibroblasts are used for the induction of hCiPSCs. Four stages are used for the reprogramming process and the detailed induction medium for each stage is provided. In addition, we provide a troubleshooting list for the induction process.