bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship Between MR Spectroscopy-Detected Glutamatergic Neurometabolites and Changes in Social Behaviors in a Pilot Open-Label Trial of Memantine for Adults With Autism Spectrum Disorder
Authors: Nair Neetu , Hegarty John Patrick , Cirstea Carmen Mihaela , Gu Meng , Appling Carrina Brooke , Beversdorf David Quentin 
Published: July 2022

BackgroundThe neurobiology underlying ASD is largely unknown but altered neural excitability/inhibitory ratios have been reported. Memantine is an N-methyl-D-aspartate (NMDA) glutamatergic antagonist studied for the treatment of core ASD symptoms, with mixed results. We examined whether glutamatergic levels were associated with and predicted response to memantine in an exploratory pilot study.MethodsTen adult participants with ASD underwent proton magnetic resonance spectroscopy (1H-MRS) imaging at baseline and behavioral assessments before and after 12-weeks of open-label memantine. Post-treatment scores on Clinical Global Impressions–Improvement (CGI-I) for social interaction were the primary outcome measure, and scores on the Social Responsiveness Scale (SRS) were included as a secondary outcome. LCModel was used to quantify the concentrations of Point RESolved Spectroscopy-detected glutamate+glutamine (Glx) (and other neurometabolites, i.e., N-acetylaspartate, NAA; creatine+phosphocreatine, Cr+PCr, and myo-inositol, Ins), within the left dorsolateral prefrontal cortex (LDLPFC) and right (R) posterolateral cerebellum. SPM was used to perform brain tissue segmentation within the spectroscopic voxels. CGI-I scores post-treatment were used to classify the participants into two groups, responders (scores 1–3; n = 5) and non-responders (scores 4–7, or withdrew due to increase behaviors; n = 5). Independent samples t-tests, partial correlations and linear hierarchical regression models (SPSS) were used to determine between-group differences in neurometabolite concentrations and associations between neurometabolites and behavioral scores.ResultsResponders and non-responders did not significantly differ in Glx levels in any region of interest, but differed in NAA levels in LDLPFC (higher in responders vs. non-responders). Although changes in CGI-I social scores were not correlated with Glx in any region of interest, the linear hierarchical regression did reveal that Glx and Ins levels in LDLPFC were predictors of post-treatment CGI-I social scores. Changes in SRS scores were correlated with baseline Cr+PCr levels in the LDLPFC.DiscussionOur pilot data suggest that baseline Glx, a marker of glutamatergic neurotransmission, did not directly predict response to memantine for social outcomes in adults with ASD. However, interactions between Glx and the neurometabolite associated with glial integrity (Ins) may help predict treatment response. Further, those with highest baseline NAA, a putative neuronal marker, and Cr+pCr, a brain energy metabolism marker, were the best responders. These preliminary results may explain some of the mixed results reported in previous memantine trials in ASD. Future studies will need to examine these results in a larger sample.
Relationship between unmet needs for assistance and healthy aging among disabled older adults in China
Authors: Cao Yang , Feng Yuxin , Luo Yaling 
Published: July 2022

BackgroundAlthough there is a growing consensus around the world that long-term care services and supports are important to help the aged population with disabilities achieve healthy aging, a misallocation of care resources and inefficiency in care delivery still exist in China. The absence or inadequate provision of long-term care services and supports among older adults with disabilities results in a range of adverse health consequences. However, the negative influence of unmet needs for assistance on healthy aging, based on functional perspectives including physiological, psychological, and societal domains, has been underestimated. This study aimed to measure healthy aging based on a person-centered approach and examine the relationship between unmet needs for assistance and healthy aging among older adults with disabilities in China.MethodsBased on the data from the Chinese Longitudinal Healthy Longevity Survey 2018, we used the latent profile analysis with three indicators to uncover distinctive types of older adults experiencing distinct levels of healthy aging, and applied the ordered logit regression to analyze the correlation between unmet needs for assistance and different levels of healthy aging. To further address the endogeneity bias, the robust test was conducted by the two-stage least-squares instrumental variable estimation and the conditional mixed process instrumental variable estimation.ResultsThree ordered latent classes were identified: a low level of healthy aging (42.83%), a middle level of healthy aging (47.27%), and a high level of healthy aging (9.90%). Disabled older adults with unmet needs had a lower probability of achieving the higher level of healthy aging (OR = 0.57, SE = 0.04, CI = 0.48–0.66, p &lt; 0.001).ConclusionsThis study highlights the need to increase awareness among gerontological practitioners with respect to long-term care services and supports for disabled older adults as a potential for enhancing their healthy aging, and that unmet needs could be a basis for risk assessment and a means for determining the efficacy of long-term care interventions on maintaining health.
The role of e-health literacy and some cognitive factors in adopting protective behaviors of COVID-19 in Khalkhal residents
Authors: Rezakhani Moghaddam Hamed , Ranjbaran Soheila , Babazadeh Towhid 
Published: July 2022

BackgroundSeveral vaccines have recently been generated and are being utilized to prevent COVID-19 mortality. Although the disease is causing many fatalities worldwide, preventative practices should be prioritized, even if vaccines are available. Therefore, this study aimed to identify the role of e-health literacy and some cognitive factors in adopting protective behaviors against COVID-19 in Khalkhal residents.MethodsIn the present cross-sectional study we recruited 380 people aged 18–65 according to cluster sampling from September 2021 to December 2021 in Khalkhal County, Iran. Reliable and validated tools were applied to data collection, including the eHealth Literacy Scale (eHEALS) in Persian and the Cognitive factors assessment questionnaire based on the Health Belief Model (HBM). Data were analyzed using Chi-square, one-way ANOVA, independent samples t-test, and bivariate correlation. The predictors were also determined using hierarchical linear regression analysis.ResultsThe average age of the participants was 35.26 ± 11.51 years. The regression analysis implied that gender (p-value = 0.032), education level (p-value = 0.001), occupational status (p-value = 0.002), income (p-value = 0.001), and marriage (p-value = 0.001) had statistically significant associations with e-HL. Additionally, education level (p-value = 0.001), occupational status (p-value = 0.001), income (p-value = 0.001), and marriage (p-value = 0.002) revealed statistically significant associations with COVID-19 preventive behaviors. Approximately 16.5% of the variation in the COVID-19 protective behaviors is explained by the cognitive factors and the demographic variables. Overall, demographic, cognitive, and e-HL variables were able to explain roughly 35.5% of the variation in COVID-19 protective behaviors. Furthermore, self-efficacy was the strongest predictor of protective behaviors (β = 0.214).ConclusionsHBM constructs successfully predicted the role of e-health literacy and some cognitive factors in adopting COVID-19 protective behaviors. People with high socioeconomic levels were better at e-health literacy and COVID-19 protective behaviors during the pandemic. Moreover, applying approaches to adopting COVID-19 protective behaviors is essential, especially in low socioeconomic status (SES) groups.
Effects of mental fatigue on technical performance in soccer players: A systematic review with a meta-analysis
Authors: Sun He , Soh Kim Geok , Mohammadi Alireza , Wang Xuanji , Bin Zuchang , Zhao Zijian 
Published: July 2022

BackgroundMental fatigue largely influences technical performance in soccer, including offensive and defensive skills. However, these effects on technical performance among the soccer players have not yet been aggregated to be assessed systematically.ObjectiveThe purpose of the review was to evaluate the impact of mental fatigue on soccer players' overall technical skills.MethodsDrawing on Web of Science, PubMed, Scopus, and EBSCOhost (CENTRAL and SPORTDicus), an in-depth search was conducted. PICOS established the eligibility criteria to select the studies as follows: (i) population—healthy soccer players; (ii) intervention—involving any mental-fatigue-prompted protocol; (iii) comparison—control conditions (active or passive without inducing mental fatigue); (iv) outcomes—technical performance (offensive and defensive skill); and (v) study design—randomized controlled trials.ResultsA total of eight studies were qualified for inclusion in the systematic literature review. Overall, the results indicate that mental fatigue had significant effects on technical skills, including offensive and defensive skills. Specifically, there were significant effects on errors (ES = 0.977; p &lt; 0.001), number of tackles (ES = −0.739; p = 0.005), and the percentage of successful tackles (ES = −0.628; p = 0.022), while there were no significant effects on the number of passes (ES = 0.240; p = 0.328), the percentage of accurate passing (ES = −0.008; p = 0.985), and the number of successful passes (ES = −0.322; p = 0.217).ConclusionOverall, a significant effect of mental fatigue on the technical performance (e.g., tackles and errors) of soccer players was detected, while no significant effects on passing skills were detected. Future studies may consider investigating technical performance together with other important results (e.g., decision-making skills or internal load).Systematic Review Registrationhttps://inplasy.com/inplasy-2022-2-0008/, Inplasy protocol 202220008.
Mental Health Inequities Amid the COVID-19 Pandemic: Findings From Three Rounds of a Cross-Sectional Monitoring Survey of Canadian Adults
Authors: Jenkins Emily K. , Slemon Allie , Richardson Chris , Pumarino Javiera , McAuliffe Corey , Thomson Kimberly C. , Goodyear Trevor , Daly Zachary , McGuinness Liza , Gadermann Anne 
Published: July 2022

Objectives: Adverse mental health impacts of the COVID-19 pandemic are well documented; however, there remains limited data detailing trends in mental health at different points in time and across population sub-groups most impacted. This paper draws on data from three rounds of a nationally representative cross-sectional monitoring survey to characterize the mental health impacts of COVID-19 on adults living in Canada (N = 9,061).Methods: Descriptive statistics were used to examine the mental health impacts of the pandemic using a range of self-reported measures. Multivariate logistic regression models were then used to quantify the independent risks of experiencing adverse mental health outcomes for priority population sub-groups, adjusting for age, gender, and survey round.Results: Data illustrate significant disparities in the mental health consequences of the pandemic, with inequitable impacts for sub-groups who experience structural vulnerability related to pre-existing mental health conditions, disability, LGBTQ2+ identity, and Indigenous identity.Conclusion: There is immediate need for population-based approaches to support mental health in Canada and globally. Approaches should attend to the root causes of mental health inequities through promotion and prevention, in addition to treatment.
Effectiveness of Herbal Essential Oils as Single and Combined Repellents against Aedes aegypti, Anopheles dirus and Culex quinquefasciatus (Diptera: Culicidae)
Authors: Sutthanont Nataya , Sudsawang Monthatip , Phanpoowong Theerawit , Sriwichai Patchara , Ruangsittichai Jiraporn , Rotejanaprasert Chawarat , Srisawat Raweewan 
Published: July 2022

Mosquito repellents reduce human-vector contact of vector-borne diseases. We compared the repellent activity of 10 undiluted essential oils (anise, basil, bergamot, coriander, patchouli, peppermint, petitgrain, rosemary, sage and vetiver) against A. aegypti, A. dirus and C. quinquefasciatus using the arm-in-cage method. Petitgrain oil was the most effective against A. aegypti (270 min). Peppermint oil was the most effective against A. dirus (180 min). Interestingly, all single oils had attributes of repellency against C. quinquefasciatus (ranged, 120–360 min). Moreover, we integrated their binary combinations of highly effective essential oils against A. aegypti and A. dirus to potentially increase the protection time. A 1:1 combination of petitgrain/basil, petitgrain/coriander, basil/coriander and basil/sage reduced the median complete-protection time of 150 min for A. aegypti; a combination of sage and patchouli oils prolonged the median complete-protection time of 270 min for A. dirus. Combining essential oils effect protection time from these two mosquito species.
La brecha digital en las instituciones educativas fiscales de Manta: Situación actual, necesidades y desafíos
Authors: Álava Chávez Ingrid Yadira , Muñoz Verduga Dolores Esperanza 
Published: July 2022

Para ciertos grupos vulnerables de la población, les es difícil e incluso imposible acceder a la educación virtual, las desigualdades socioeconómicas acrecientan la brecha digital, lo que impide el desarrollo. Esta investigación describe como el analfabetismo tecnológico amplía la brecha digital en las instituciones educativas fiscales de Manta Post COVID periodo 2021-2022. Se realizó un estudio de tipo descriptivo documental, utilizando el método de análisis-síntesis y el deductivo-inductivo, que ayudaron en la revisión de la literatura científica. Se demuestra que, la gestión realizada por el MINEDUC ha logrado dar acceso al internet al 97% de las instituciones educativas, lo que contrasta respecto a la dotación de equipos tecnológicos, que alcanza un 2% de la población educativa de Manta. Se debe destinar una mayor asignación económica para educación, enfocado a la adecuación de espacios y dotación de equipos informáticos, y en especial una capacitación efectiva a sus docentes.
Síndrome de Burnout en docentes de una universidad pública ecuatoriana
Authors: Anzules Guerra Jazmín Beatriz , Rojas González Liliana , Véliz Zevallos Ingebord Josephine , Loor Vélez Katiuska Elizabeth , Menéndez Pin Tania del Rocío , Milian Hernández Eduardo Josué 
Published: July 2022

El docente universitario está constantemente inmerso en un ambiente de trabajo, que le exige un desempeño laboral con gran gasto energético físico y psicológico, pudiendo afectar su salud. El objetivo de este trabajo fue evaluar el síndrome de Burnout en docentes de la Facultad de Ciencias de la Salud de la Universidad Técnica de Manabí, Ecuador, desde junio de 2018 a junio de 2021, mediante una investigación de tipo descriptiva, transversal, de campo y prospectiva, con diseño no experimental, en 53 docentes de diferentes niveles académicos. Prevalecieron las mujeres (73,6 %), mayores de cincuenta años (52,8 %). Destacó la falta de realización personal (40,77 ± 8,48), sin diferencias entre sexos, pero con respecto a la edad sobresalieron los menores de cincuenta años con la dimensión de agotamiento emocional (p˂0,05). No hubo predominio de niveles altos para la tríada del síndrome de Burnout, no obstante, hubo casos de docentes titulares con las tres dimensiones altas. En conclusión, los docentes, perciben altamente falta de realización personal y se detectaron casos del síndrome de Burnout, específicamente en docentes titulares, recomendándose su intervención y así promover la salud del profesor universitario y por ende un buen desempeño.
Palabras clave: Síndrome de Burnout; enseñanza superior; profesores universitarios.
Nivel de conocimiento y actitud cultural sobre enfermedad diarreica aguda en madres de infantes escolares. Cantón Santa Elena
Authors: Suárez Yagual Elsie Zoraida , Salinas Salinas Sonnia del Carmen , Díaz Amador Yanedsy 
Published: July 2022

Se realizó estudio mixto, descriptivo, correlacional y transversal con el objetivo de poder evaluar el nivel de conocimiento y actitud cultural sobre la enfermedad diarreica aguda en madres de infantes escolares, cantón Santa Elena, en el período de mayo a diciembre 2019. El universo lo representó 108 madres y la muestra por 88 binomios madres/escolares. El método empleado fue observacional probabilístico aleatorio simple con un margen de error 5 %; las variables estudiadas fueron nivel de conocimientos y actitud cultural mediante la encuesta aplicada. Se utilizó Chi-Cuadrado para el análisis inferencial de criterios. La instrucción primaria alcanzó 54 (61,40 %), en relación al 61,36 % con calificación deficiente e inadecuado nivel de conocimiento sobre la enfermedad (p=0,000); en cambio 50 (56 %) acudió a farmacias; 22 (25 %) automedicaron a sus hijos y 16 (18,18 %) asistieron a unidades de salud como actitud cultural de su preferencia; con relevancia del rango de edades entre 25 y 34 años (p=0,000). Se concluye que prevalece el deficiente nivel de conocimiento sobre la diarrea aguda en madres de nivel académico primario, con asociación importante a la actitud y decisiones tomadas que no fueron las más adecuadas, lo cual llevó a proponer estrategias de promoción y prevención sobre la enfermedad.
Palabras clave: actitud; conocimiento; diarrea infantil; infantes; madres.
ANALISIS METODE KOMUNIKASI SBAR (SITUATION, BACKGROUND, ASSESMENT, RECOMENDATION) DI INSTALASI GAWAT DARURAT
Authors: Safitri Wahyuningsih , Suparmanto Gatot , Istiningtyas Anita 
Published: July 2022

Komunikasi efektif yang tepat waktu, akurat, lengkap, jelas, dan dipahami oleh penerima mengurangi kesalahan dan meningkatkan keselamatan pasien. Komunikasi SBAR (Situation, Background, Assassement, Recomendation) adalah metode komunikasi yang digunakan untuk anggota tim medis kesehatan dalam melaporkan kondisi pasien. Penelitian ini bertujuan untuk menganalisis metode komunikasi SBAR (Situation, Background, Assassement, Recomendation) di Instalasi Gawat Darurat. Penelitian ini merupakan penelitian kuantitatif deskriptif. Pemilihan sampel dengan total sampling. Alat penelitian adalah kuesioner tentang pelaksanaan komunikasi SBAR di ruang IGD. Hasil menunjukkan komunikasi situation paling banyak adalah cukup yaitu sebanyak 18 responden (52, 9%), komunikasi background paling banyak adalah baik yaitu sebanyak 16 responden (47, 1%), komunikasi assesment paling banyak adalah baik yaitu sebanyak 21 responden (61,8%), komunikasi recomendation paling banyak adalah baik yaitu sebanyak 20 responden (58,8%).
Effective communication that is timely, accurate, complete, clear, and understood by the recipient reduces errors and improves patient safety. SBAR (Situation, Background, Assessment, Recommendation) communication is a communication method used for members of the health medical team in reporting the patient's condition. This study aims to analyze the SBAR (Situation, Background, Assessment, Recommendation) communication method in the Emergency Room. This research is a descriptive quantitative research. Sample selection by total sampling. The research tool is a questionnaire about the implementation of SBAR communication in the emergency room. The results show that the most situational communication is sufficient, namely as many as 18 respondents (52.9%), the most background communication is good, namely as many as 16 respondents (47.1%), the assessment communication is mostly good, namely as many as 21 respondents (61.8). %), the most recommended communication is good, as many as 20 respondents (58.8%).
The National Blood Service in the Modern History of Belarus. Overview for 1991–2021
Authors: Гольдинберг Б.М. , Климович О.В. 
Published: July 2022

Развитие службы крови в Республике Беларусь тесно связано с общими преобразованиями в трансфузионной медицине в международном масштабе, однако оно имеет и свои национальные особенности.Цель исследования. Провести анализ причинно-следственных событий в современной национальной трансфузиологии и определить тенденции ее развития.Материалы и методы. В качестве источников использованы статистические и архивные документы учреждений службы крови Республики Беларусь, а также литературные публикации.Результаты и обсуждение. Проведен сравнительный анализ влияния разных законодательных и структурных моделей службы крови, модернизации ее материально-технической базы на комплектование донорских кадров и производственную деятельность. Обсуждаются проведенные мероприятия с 1991 по 2021 г. для преодоления возникших проблем. Показан вклад организаторов здравоохранения и белорусских ученых в развитие производственной и клинической трансфузиологии. Определена тенденция развития национальной службы крови на ближайшую перспективу.Выводы. Изучение национальной службы крови в новейшей истории Беларуси с помощью применения методологии СБТ-систем позволяет провести ее комплексный анализ, включающий экономические и социальные факторы. Сформулирована новая парадигма трансфузионной медицины: переход от доктрины компонентной гемотерапии к молекулярной трансфузиологии.
The development of the blood service in the Republic of Belarus is closely related to the general transformations in transfusion medicine on an international scale but it also has its own national characteristics.Purpose. To analyze the causal events in the modern national blood service and determine the trends of its development.Materials and methods. Statistical and archival documents of the blood service institutions of the Republic of Belarus as well as data from literary publications have been used as sources.Results and discussion. A comparative analysis of the impact of different legislative and structural models of the blood service, the modernization of its material and technical base on the recruitment of donor personnel and production activities have been carried out. The activities carried out from 1991 to 2021 to overcome the problems encountered are discussed. The contribution of healthcare organizers and Belarusian scientists in the development of industrial and clinical transfusiology is shown. The development tendency of the national blood service in the near future has been determined.Conclusions. The study of the national blood service in the recent history of Belarus using the sociobiotechnical (SBT) systems methodology allows for its comprehensive analysis including economic and social factors.A new paradigm of transfusion medicine has been formulated: the transition from the doctrine of component hemotherapy to molecular transfusiology.
Robust Fano resonance induced by topologically protected interface modes interference at gigahertz
Authors: Gu Xin , Liu Gui-dong , Wang Ling-ling , Lin Qi 
Published: July 2022

Abstract
We theoretically realize a highly robust Fano resonant structure. The occurrence of robust Fano resonance can be caused by the coupling of topological bright interface mode and topological dark interface mode at the interface between trivial and non-trivial insulators. Through the research of band structure, it is confirmed that the structure has the characteristic of specific band inversion, which can realize the topological phase transition. In addition, we verify that the Fano resonance is still robust in horizontal and vertical perturbations, which is significant for designing Fano-based devices to solve issues caused by manufacturing.