bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bio-Catalysis for the Functionalization of Cellulose Nanocrystals
Authors: Peponi Laura , Barrera-Rivera Karla A. , Kenny José M. , Marcos-Fernandez Ángel , Martinez-Richa Antonio , López Daniel 
Published: November 2022

In this work, the chemical modification of cellulose nanocrystals (NCs) using an enzyme as a catalyst has been performed by a “grafting from” reaction, in order to covalently functionalize the external surface of NCs with both poly(L-lactic acid) (PLLA) and poly(ε-caprolactone) (PCL) by ring-opening polymerization. Firstly, cellulose nanocrystals were prepared from commercial cellulose microcrystals by acid hydrolysis and then functionalized by using Yarrowia lipolytica lipase immobilized on Lewatit resin as a catalyst. To confirm the success of the grafting reactions, 1H-NMR has been performed as well as FT-IR and Raman spectroscopy. Moreover, thermogravimetric analysis has been used to determine the amount of polymeric chains grafted onto the surface of cellulose nanocrystals. Furthermore, the crystalline nature of the polymeric chains grafted onto the cellulose surface has been studied by DSC, X-ray scattering, as well as SAXS analysis. To our knowledge, it is the first time that a biocatalyst approach has been used to obtain biopolymeric functionalized cellulose nanocrystals.
Lacticaseibacillus rhamnosus MG4706 Suppresses Periodontitis in Osteoclasts, Inflammation-Inducing Cells, and Ligature-Induced Rats
Authors: Kim Seonyoung , Lee Ji Yeon , Park Jeong-Yong , Kim YongGyeong , Kang Chang-Ho 
Published: November 2022

Periodontitis is a chronic inflammatory disease characterized by tooth loss due to inflammation and the loss of alveolar bone. Periodontitis is closely related to various systemic diseases and is emerging as a global health problem. In this study, we investigated the anti-inflammatory effect of lactic acid bacteria (LAB) in vitro on Porphyromonas gingivalis (P. gingivalis) LPS-activated RAW264.7 and human gingival fibroblasts-1 (HGF-1) cells and the anti-osteoclastogenic effect of LAB on RANKL-induced RAW264.7 cells. All LAB strains (Lacticaseibacillus rhamnosus MG4706, MG4709, and MG4711) inhibited nitric oxide (NO)/inducible nitric oxide synthase (iNOS) in P. gingivalis LPS-activated RAW264.7 cells and pro-inflammatory cytokines (IL-1β and IL-6) and matrix metalloproteinase (MMP-8 and MMP-9) in HGF-1 cells. In addition, LAB treatment inhibited osteoclastogenesis by reducing tartrate-resistant acid phosphatase (TRAP) activity and cathepsin K (CtsK) through the downregulation of nuclear factor of activated T cells cytoplasmic 1 (NFATc1) and c-fos gene expression in RANKL-induced RAW264.7 cells. Administration of MG4706 alleviated alveolar bone loss indices and reduced the gene expression of IL-1β, IL-6, MMP-8, MMP-9, and RANKL/OPG ratio in gingival tissue. In conclusion, L. rhamnosus MG4706 has the potential to alleviate periodontitis.
Novel Mycoviruses Discovered from a Metatranscriptomics Survey of the Phytopathogenic Alternaria Fungus
Authors: Wang Wenqing , Wang Xianhong , Tu Chunyan , Yang Mengmeng , Xiang Jun , Wang Liping , Hong Ni , Zhai Lifeng , Wang Guoping 
Published: November 2022

Alternaria fungus can cause notable diseases in cereals, ornamental plants, vegetables, and fruits around the world. To date, an increasing number of mycoviruses have been accurately and successfully identified in this fungus. In this study, we discovered mycoviruses from 78 strains in 6 species of the genus Alternaria, which were collected from 10 pear production areas using high-throughput sequencing technology. Using the total RNA-seq, we detected the RNA-dependent RNA polymerase of 19 potential viruses and the coat protein of two potential viruses. We successfully confirmed these viruses using reverse transcription polymerase chain reaction with RNA as the template. We identified 12 mycoviruses that were positive-sense single-stranded RNA (+ssRNA) viruses, 5 double-strand RNA (dsRNA) viruses, and 4 negative single-stranded RNA (−ssRNA) viruses. In these viruses, five +ssRNA and four −ssRNA viruses were novel mycoviruses classified into diverse the families Botourmiaviridae, Deltaflexivirus, Mymonaviridea, and Discoviridae. We identified a novel −ssRNA mycovirus isolated from an A. tenuissima strain HB-15 as Alternaria tenuissima negative-stranded RNA virus 2 (AtNSRV2). Additionally, we characterized a novel +ssRNA mycovirus isolated from an A. tenuissima strain SC-8 as Alternaria tenuissima deltaflexivirus 1 (AtDFV1). According to phylogenetic and sequence analyses, we determined that AtNSRV2 was related to the viruses of the genus Sclerotimonavirus in the family Mymonaviridae. We also found that AtDFV1 was related to the virus family Deltaflexivirus. This study is the first to use total RNA sequencing to characterize viruses in Alternaria spp. These results expand the number of Alternaria viruses and demonstrate the diversity of these mycoviruses.
Impactos preliminares da COVID-19 nas operadoras de grande porte da saúde suplementar brasileira
Authors: Teixeira Isabela Tatiana , Alves Filho Alceu Gomes , Torkomian Ana Lúcia Vitale , Romano André Luiz 
Published: November 2022

Introdução – Esse estudo aborda dados preliminares dos efeitos da pandemia da covid-19 nas empresas privadas de grande porte de assistência de saúde. Para efeitos dessa pesquisa, foram consideradas as 5 maiores operadoras médico-hospitalares do brasil.
Objetivo – Apresentar os resultados preliminares dos movimentos estratégicos das 5 maiores operadoras médico-hospitalares durante o período de pandemia da Covid19.
Metodologia – O trabalho utilizou informações oriundas de fontes secundárias, com análise de conteúdos de publicações e da base de dados históricos da ANS, bem como dados apresentados no site das próprias empresas (internet e intranet, para análise descritiva dos impactos preliminares da COVID-19 nas operadoras selecionadas para o estudo.
Resultados - Foi possível observar um discreto aumento no número de beneficiários das operadoras, e uma redução relevante na sinistralidade em 2020, em praticamente todas as empresas do setor. Diferentemente de outros anos, em que o crescimento de beneficiários era reflexo do aquecimento econômico nos setores produtivos no país, o movimento observado durante a pandemia está relacionado com o medo da população em não ter acesso aos recursos de saúde necessários caso afetada diretamente pela covid. A queda na sinistralidade tem relação com a redução no número de atendimentos médicos e de internações com procedimentos agendados, e impactaram na redução dos custos assistenciais.
Conclusões - Os efeitos da pandemia ainda são de curtíssimo prazo, e não é possível afirmar que os resultados econômico-financeiros obtidos em 2020 serão mantidos, e nem que as empresas analisadas não serão mais afetadas pela crise num futuro próximo, porém os resultados indicam que pontualmente a pandemia trouxe novos beneficiários e redução nos custos das operadoras analisadas.
Exploring Interdisciplinary Collaborative Online Learning Spaces through Sociomateriality in Cape Town, South Africa
Authors: Van den Berg Carolien , Verster Belinda 
Published: November 2022

With the rapid adoption of online learning spaces since the advent of COVID-19, more and more calls are being made in higher education to move from emergency remote teaching and learning to appropriate online education. Although much has been written about the designing of online learning from both a technological and pedagogical perspective, limited contemporary literature is available to understand the complexity of interdisciplinary collaborative online learning. This limitation is investigated in this paper that reports on the first iteration of a Design-Based Research (DBR) study. Within this iteration, a qualitative exploratory research design that applies an inductive approach between researchers from Information Systems (IS) and Urban Planning (URP) is discussed. The aim was to develop design principles for interdisciplinary collaborative online learning spaces. This paper reports on the data generated during a semester-long, inter-institutional, interdisciplinary student project that was embedded in co-creating social digital innovations for pressing environmental problems faced by marginalised communities in Cape Town, South Africa. The participants for this study are 38 Honours degree IS students and 22 Advanced Diploma URP students (N=60). Participants, individually and in groups, completed a total of three reflective structured questionnaires using Google Forms during the semester that generated the dataset for this paper. The theoretical framing that underpins this research study is sociomateriality. The attraction to sociomateriality is its ability to not merely shift attention from the human to the non-human but rather a focus on entanglements and the interrelated nature of components that constitute the learning space. This focus on entanglements is needed for an understanding of the complexities associated with interdisciplinary collaborative online learning. Engaging this complex learning space through the data has revealed four design principles namely: (1) creating immersive context-sensitive learning experiences, (2) designing opportunities to collaboratively (co)-construct knowledge, (3) focusing on the intra-action of socio-technical and socio-cultural entanglements and (4) foregrounding relationality as a tool to foster agency. It is argued in this paper that the aforementioned design principles are necessary for developing interdisciplinary collaborative online learning spaces that afford students a complex learning experience. Complex learning is considered fundamental in developing abilities in students to appropriately respond to the myriad 21st-century societal challenges that await.
Los dilemas del derecho como ciencia en el ámbito de la globalización y la era digital
Authors: Torres Guzmán Flor María 
Published: November 2022

El proceso de globalización se ha constituido y consolidado como un paradigma de contextualización entre la Ciencia del Derecho y los avances de los sistemas tecnológicos en la era digital; permitiendo fundamentar la necesidad de adecuar un escenario de armonía jurídica en concordancia con los retos que han sido instituidosen la época posmoderna, ante los continuos avances e innovaciones científicas.
EDUKASI KESEHATAN IBU HAMIL TENTANG PELAYANAN ANTENATAL TERPADU, IMD, ASI EKSKLUSIF DI WILAYAH PUSKESMAS DUREN JAYA
Authors: Nofa Anggraini  , Ita Herawati  , Lia Idealistiana  , Lucy Amelia  
Published: November 2022

Pendahuluan: Cakupan IMD dan pemberian ASI Esklusif juga masih rendah. Informasi dari bidan diperoleh kebanyakan para ibu hanya memeriksakan kandungan pada awal kehamilan hanya untuk memastikan kondisi mereka. Beberapa ibu juga menyatakan bahwa mereka tidak merasa terlalu kuatir kerena sudah berpengalaman dengan kelahiran sebelumnya. hal ini mengindikasikan bahwa masih adanya ibu hamil yang belum mengerti sepenuhnya tentang betapa pentingnya kunjungan ANC secara teratur dan sesuai dengan standar yang ditetapkan, karena dengan memeriksakan kehamilan secara rutin pada kehamilan akan dapat menurunkan mortalitas dan morbiditas pada ibu hamil.
Metode: Metode yang digunakan adalah ceramah, diskusi dan tanya jawab dilengkapi dengan video dan menggunakan LCD.
Hasil: Meningkatnya pengetahuan ibu hamil sehingga nantinya proses kelahiran lancar dan bayi pun sehat, dan para ibu yang telah mendapatkan informasi yang tepat dapat menjadi influencer bagi masyarakat di sekitarnya untuk menggalakkan kepatuhan ANC dan pemberian ASI Eksklusif.
Kesimpulan: Meningkatkan pemahaman ibu hamil tentang pentingnya pelayanan ANC terpadu, pelaksaan IMD dan pemberian ASI Eksklusif
Are you listening to me? Understanding children's rights through Hungarian pedagogic practice
Authors: Canning Natalie , Teszenyi Eleonora , Pálfi Sandor 
Published: November 2022

Hungarian pedagogues agree that children should be listened to, have their rights recognised, and their voices heard. The UNCRC recommends that children’s rights should be part of early childhood education, but this is not typical in Hungarian kindergartens and there is little pedagogical material to support the education of children about their rights. This paper focuses on 5 kindergartens each typically accommodating over 150 children between the ages of 3-6 years old across Hungary. Six pedagogues worked with multi-age groups (4 kindergartens) and same-age groups (2 kindergartens). The research adopted participatory methods to gather children’s views recognising them as valuable collaborators. Children provided insight into their own lives through play based creative activities that focused on eliciting children’s thoughts and feelings. Pedagogues collected video data using a ‘toolkit’ of children’s play activities during a 6-week period of the COVID-19 pandemic. Pedagogues reflected on children’s play through a series of online focus groups with emphasis on how children expressed their views and preferences through play. Participants were encouraged to examine the power relationships between children and adults and analyse their role in knowledge production rather than knowledge extraction. Six themes emerged through thematic analysis, mapped to the 4 guiding principles of children’s rights: participation, survival, development and protection. The findings highlight the juxtaposition between children’s life-as-experienced and life-as-told by adults; the skill of pedagogues to hear and sensitively interpret children’s voices based on their play and the challenge to slow down and reflect on practice.
SKYSURF-3: Testing Crowded Object Catalogs in the Hubble eXtreme Deep Field Mosaics to Study Sample Incompleteness from an Extragalactic Background Light Perspective
Authors: Kramer Darby M. , Carleton Timothy , Cohen Seth. H. , Jansen Rolf , Windhorst Rogier A. , Grogin Norman , Koekemoer Anton , MacKenty John W. , Pirzkal Nor 
Published: November 2022

Abstract
Extragalactic background light (EBL) studies have revealed a significant discrepancy between direct measurements—via instruments measuring “bare” sky from which Zodiacal and Galactic light models are subtracted—and measurements of the integrated galaxy light (IGL). This discrepancy could lie in either method, whether it be an incomplete Zodiacal model or missed faint galaxies in the IGL calculations. It has been proposed that the discrepancy is due to deep galaxy surveys, such as those with the Hubble Space Telescope, missing up to half of the faint galaxies with 24 ≲ m
AB ≲ 29 mag. We address this possibility by simulating higher number densities of galaxies, and so assess incompleteness due to object overlap, with three replications of the Hubble UltraDeep Field (HUDF). SourceExtractor is used to compare the recovered counts and photometry to the original HUDF, allowing us to assess how many galaxies may have been missed due to confusion, i.e., due to blending with neighboring faint galaxies. This exercise reveals that, while up to 50% of faint galaxies with 28 ≲ m
AB ≲ 29 mag were missed or blended with neighboring objects in certain filters, not enough were missed to account for the EBL discrepancy alone in any of the replications.
Double Shadows at the Lunar Poles
Authors: O’Brien Patrick , Byrne Shane 
Published: November 2022

Abstract
Topographic depressions within permanently shadowed regions (PSRs) on low-obliquity planetary bodies can be shielded not only from direct illumination, but also from scattered sunlight and thermal emission from nearby sunlit surfaces. We apply an illumination model to high-resolution topography data to produce the first map of double shadows at the lunar poles. The total doubly shadowed area resolved at the 30 m scale is 1.47 km2 in the northern hemisphere and 5.37 km2 in the southern hemisphere, predominantly contained within small craters on the floors of large permanently shadowed craters. In total, ∼0.04% of PSR area is permanently double shadowed, but the largest double shadows are nearly 600 m across, potentially large enough to be resolved in remote sensing temperature measurements. In the absence of secondary heating sources, double shadows are predicted to be significantly colder than singly shadowed areas and could sequester highly volatile compounds like carbon dioxide. Future in situ investigation of the regions identified in this work can elucidate the origin and distribution of the Moon’s most volatile deposits.
Une politisation du droit par contentieux et antagonismes ? Droit des étrangers, droit de la propriété intellectuelle
Authors: Mekdjian Sarah 
Published: November 2022

Si les droits et les discours sur les droits participent d’une mystification de l’exploitation, que peut signifier créer des antagonismes depuis le droit et les scènes judiciaires ? A partir de contentieux qui les opposent à plusieurs préfectures, les co-auteurs du Bureau des dépositions, avec le conseil d’avocats, confrontent et associent deux droits, rarement reliés, et qui, pourtant, participent ensemble de processus de frontiérisation : le droit de la propriété intellectuelle et le droit des étrangers. En associant ces droits, comment œuvrer à leur possible politisation ?
Religion, fait religieux et management
Authors: Cintas Caroline , Brière Sophie , Gao Hèliot YingFei , Pasche Guignard Florence 
Published: November 2022

Notre chapitre met en lumière des situations de fait religieux non régulées par le droit dans le secteur hospitalier public dans trois contextes culturels différents : le Québec, le Royaume-Uni et la France. Rares sont les recherches qui s’intéressent à la conciliation entre rôle professionnel et religiosité dans le secteur public. Les contextes légaux au Québec et en France orientent vers la neutralité des agents de la fonction publique avec les lois sur la laïcité dans chacun des pays. Le Royaume-Uni, quant à lui, défend la liberté d’expression, en priorité, y compris dans la fonction publique. Pourtant nous montrons que la réalité des pratiques et les désirs des salariés pratiquants donnent à voir des situations plus complexes quel que soit le pays. Les données recueillies donnent la parole aux personnels soignants, médicaux et encadrants de proximité. À travers cette comparaison, nous identifions des invariants dans les situations de fait religieux et différents modes de régulation à l’hôpital public. Deux invariants sont repérés. Le premier indique que le fait religieux est socialement construit à travers les interactions manager-managé et environnement-situation de travail. Le second prouve qu’il existe un écart entre le contexte légal et les pratiques quel que soit le pays. Au Royaume-Uni, nombre de salariés-pratiquant du NHS dissimulent leur religiosité alors que le contexte légal en permet l’expression, en France, certaines expressions sont tolérées par les encadrants de proximité lorsque le rôle professionnel n’est pas remis en cause. Au Québec, le signe religieux des médecins sikhs n’est pas visible et ne présente pas de charge symbolique liée à la religion jusqu’à ce que le contexte de pandémie le révèle. Dans un second temps, nous repérons des types de régulation différents en fonctions des pays. Cette comparaison Québec, Royaume-Uni, France, nous invite à rentrer dans la complexité des situations de fait religieux et à nuancer les effets de la loi sur les pratiques religieuses au travail en particulier dans le secteur public. Elle nous incite à construire des dispositifs de gestion tenant compte des spécificités locales et à sensibiliser manager et salariés pratiquants à cette problématique.
Faire campagne sur Twitter: permanences et évolutions en contexte de campagne électorale. Le cas des candidats et candidates à l’élection européenne en Belgique, Espagne, France et Royaume-Uni
Authors: Roginsky Sandrine , De Cock Barbara 
Published: November 2022

De quelle manière les activités de la représentation politique se donnent-elles à voir sur un espace médiatique particulier, Twitter, à l’occasion des campagnes des élections européennes de mai 2014 et mai 2019 ? A partir de l’analyse comparative des biographies et des publications sur le dispositif Twitter de députés européens candidats à leur ré-élection dans quatre pays (Belgique, Espagne, France, Royaume-Uni), nous tentons d’appréhender les stratégies discursives de mise en scène de soi sur Twitter en partant du principe que celles-ci fournissent des indications sur la manière dont les députés conçoivent leurs rôles. Si en effet il est possible d’identifier différents rôles donnés à voir sur le dispositif, en 2014 comme en 2019, la standardisation des registres et la disparition des contextes d’action ne permettent pas d’en savoir en réalité beaucoup sur les députés ni de les distinguer significativement les uns des autres.
Association of 25 (OH) Vitamin D and Leptin in Individuals with Insulin Resistance
Authors: Madhu S. V. , Aslam M. , Mishra B. K. , Gupta A. , Jhamb Rajat 
Published: November 2022

Introduction:
Asian-Indian individuals with diabetes have been shown to have low vitamin D levels. Whether this hypovitamonisis D is associated with hyperleptinaemia is unclear. Also, whether this association is different in those with and without insulin resistance has not been ascertained. The present study aimed to investigate the association of 25-hydroxy vitamin D [25(OH) vitamin D] and leptin in individuals with and without insulin resistance.

Methods:
Ninety two individuals were recruited in two study groups (n = 46 each group). First group included individuals with insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR] ≥2.0). Second group included those without insulin resistance (HOMA-IR <2.0). Comparison of 25(OH) vitamin D, leptin, anthropometry, and biochemical parameters was done between two groups and correlations between 25(OH) vitamin D, leptin, and HOMA-IR were studied.

Results:
Individuals with insulin resistance were of simiar age (39.6 ± 5.3 years) and body mass index (24.4 ± 3.2 kg/m2) as those without (39.5 ± 5.2 years and 23.6 ± 3.2 kg/m2). Individuals with insulin resistance showed significantly lower 25(OH) vitamin D (17.8 ± 7.1 vs. 22.3 ± 11.6 ng/mL, P = .03) and significantly higher leptin levels (16.9 ± 15.8 vs. 9.6 ± 9.3 ng/mL, P = .09) compared to those without. Significant negative correlation was observed between 25(OH) vitamin D and leptin levels overall (r = -0.3, P = .008). HOMA-IR showed significantly negative correlation with 25(OH) vitamin D levels in individuals with insulin resistance (r = -0.33, P = .027).

Conclusion:
The present study found higher circulating leptin levels and lower 25(OH) vitamin D levels in individuals with insulin resistance. 25(OH) vitamin D levels were inversely associated with leptin levels particularly in women.