bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unifying spatiotemporal and frequential attention for traffic prediction
Authors: Guo Qi , Tan Qi , Tang Jun , Shi Benyun 
Published: January 2025

AbstractIntelligent transportation systems heavily rely on forecasting urban traffic flow, and a variety of approaches have been developed for this purpose. However, most current methods focus on exploring spatial and temporal dependencies in historical traffic data, while often overlooking the inherent spectral characteristics hidden in traffic time series. In this paper, we introduce an approach to analyzing traffic flow in the frequency domain. By integrating attention mechanisms, we comprehensively capture the hidden correlations among space, time, and frequency dimensions. By leveraging deep learning to capture spatial correlations in traffic flow and applying spectral analysis to fuse time series data with underlying periodic correlations in both the time and frequency domains, we develop an innovative traffic prediction model called the Space-Time-Frequency Attention Network (STFAN). The core of this network lies in the application of attention mechanisms, which project the hidden states of current traffic features across the space, time, and frequency domains onto future hidden states. This approach enables a comprehensive learning of the relationships between each dimension and the future states, ultimately allowing for accurate predictions of future traffic flow. We carry out experiments on two publicly available datasets from the California Department of Transportation, PeMS04 and PeMS08, to assess the performance of the proposed model. The results demonstrate that the proposed model outperforms existing baseline models in terms of predictive accuracy, particularly for mid- and long-term traffic flow forecasting. Finally, the ablation study confirmed that the frequency domain characteristics of traffic flow significantly influence future traffic conditions, demonstrating the practical effectiveness of the model.
Details on the transport of European eel larvae through the Strait of Gibraltar into the Mediterranean Sea
Authors: Freese Marko , Marohn Lasse , Ferrer Luis , Pohlmann Jan-Dag , Wysujack Klaus , Blancke Tina , Hanel Reinhold 
Published: January 2025

AbstractNumbers of European glass eels (Anguilla anguilla) monitored along the Atlantic and Mediterranean coasts of Europe currently serve as the main stock indicator in assessment of this critically endangered species. Spawning, however, takes place exclusively in the Sargasso Sea, several thousand kilometers away. The beginning of its complex lifecycle is characterized by a distant and lengthy larval drift, before the young-of-the-year reach the monitoring stations at the European coasts. The oceanic mechanisms regulating dispersal and distribution of European eel leptocephalus larvae, before they metamorphose into glass eels and colonize future growth habitats, are still poorly understood and data are scarce. Here, we present oceanographic and leptocephalus catch data from a 24-h station on board of the German Research Vessel Meteor, covering one event cycle of the tide-derived change of hydrographic conditions in the central part of the Strait of Gibraltar. Results of this study provide detailed insights on how the exchange of water masses between the Atlantic and the Mediterranean Sea may favor or prevent transport and migration of eel larvae through the Strait, which potentially plays a decisive role in timing and magnitude of larval recruitment events into the entire Mediterranean region.
DNA mismatch repair (MMR) genes expression in lung cancer and its correlation with different clinicopathologic parameters
Authors: Farrag Mayada Saad , Abdelwahab Heba Wagih , Abdellateef Amr , Anber Nahla , Ellayeh Mohamed Adel , Hussein Dalia Tawfeek , Eldesoky Ahmed Ramadan , Sheta Heba 
Published: January 2025

AbstractLung cancer (LC) is a crucial rapidly developing disease. In Egypt, it is one of the five most frequent cancers. Little is known about the impact of deleted mismatch repair genes and its correlation to clinicopathological characteristics. This study evaluates immunohistochemical expression of the mismatch repair genes (PMS2), (MSH2), (MLH1) & (MSH6) & its correlation with clinicopathologic parameters & prognosis of LC. Age was higher with lost MLH1 & PMS2 but HTN was higher with lost four markers. Smoking was associated with expression of MLH1 & PMS2. A progressive course was associated with lost MSH2 & MSH6. Suprarenal metastasis was associated with lost all markers but bone metastasis was associated with lost MSH2 & MSH6. All the markers were significantly correlated with each other, with perfect correlations between MSH6 & MSH2 and between MLH & PMS2. Median overall survival among cases with lost markers was significantly lower than patients with preserved markers. We recommend evaluation of the four proteins as a biomarker that could guide LC therapy. In-depth biological research is imperative to elucidate the precise roles and mechanisms of these markers. This will advance management strategies and even guide immune checkpoint inhibitor therapy for LC.
SMYD3 drives cell cycle and epithelial-mesenchymal transition pathways through dual gene transcriptional repression and activation in HPV-negative head and neck cancer
Authors: Murali Madhavi , Saeed Abbas , Kim Sohyoung , Burkitt Kyunghee , Cheng Hui , Moshiri Arfa , Akhtar Jawad , Tsai Daniel , Luff Marie , Karim Baktiar , Saloura Vassiliki 
Published: January 2025

AbstractHuman papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type in the world and is associated with an overall poor prognosis. The protein methyltransferase SET and MYND domain-containing 3 (SMYD3), which trimethylates H3K4, activates gene transcription and enhances several oncogenic pathways, including epithelial-mesenchymal transition and cell cycle related pathways, in various cancer types. It was also recently shown that SMYD3 is overexpressed in HPV-negative HNSCC, and represses the expression of type I IFN response genes, contributing to resistance to anti-PD-1 checkpoint blockade in this disease. In this study, we show that SMYD3 depletion using siRNA interference or CRISPR decreases cellular proliferation and clonal capacity, induces cell cycle arrest and decreases the invasive potential of HPV-negative HNSCC cell lines. Accordingly, xenografts of SMYD3 knockout tumors derived from a human HPV-negative HNSCC cell line grew significantly slower compared to control tumors in mice. Genome-wide mapping for SMYD3 and H3K4me3 in HPV-negative HNSCC cells using cleavage under targets and release using nuclease (CUT&RUN) assays identified direct downstream gene targets regulated by SMYD3, including cell cycle- and EMT-promoting genes. This study provides insights into the epigenetic role of SMYD3 as an oncogene in HPV-negative HNSCC and supports SMYD3 as a rational therapeutic target in HPV-negative HNSCC.
Follow-up care needs and motivational factors for childhood cancer survivors and their parents in Germany
Authors: Ekaterina Aleshchenko , Thorsten Langer , Gabriele Calaminus , Juliane Glogner , Kathrin Hellwig , Pietro Trocchi , Enno Swart , Katja Baust 
Published: January 2025

AbstractThis study aims to explore the long-term follow-up needs and motivations of childhood and adolescent cancer survivors and their parents to attend follow-up care in Germany, given the inconsistent adherence to national follow-up guidelines. We developed interview guidelines based on the Theory of Planned Behavior and the stereotype priming model to explore motivations and barriers related to follow-up care. We conducted a total of 36 episodic narrative interviews with adolescent (ages 13–17) and adult (ages 18–45) survivors of pediatric cancer, as well as their parents. We analyzed the transcripts qualitatively using thematic content analysis, while quantitative analysis through multiple regression models was used to support the qualitative findings and identify predictors of follow-up care attendance. We identified key themes across age groups, including a strong need to “return to normal life” and a desire for ongoing organizational and social support. Both survivors and parents highlighted specific needs, including timely, personalized health information and practical help with healthcare logistics. Adolescents particularly valued emotional support from their social circles, whereas adult survivors and parents expressed a need for more structured psychosocial and logistical assistance. The findings suggest that both age and the time elapsed since diagnosis play a role in affecting survivors’ perceived control to attend guideline-based follow-up care. Our findings suggest that a differentiated approach to follow-up care, with age-appropriate support structures, and tailored guidelines, may improve adherence among survivors and their parents. To enhance follow-up care adherence among cancer survivors, healthcare providers could offer tailored, age-specific information and practical assistance with healthcare logistics. Additionally, providing emotional and psychosocial support resources for both survivors and their parents can help address their unique needs at different stages of recovery.Trial registration: Registered at German Clinical Trial Register (ID DRKS00025960 and DRKS00026092).
MAP4 kinase-regulated reduced CLSTN1 expression in medulloblastoma is associated with increased invasiveness
Authors: Sönmez Ece , Yan Shen , Lin Meng-Syuan , Baumgartner Martin 
Published: January 2025

AbstractDe-regulated protein expression contributes to tumor growth and progression in medulloblastoma (MB), the most common malignant brain tumor in children. MB is associated with impaired differentiation of specific neural progenitors, suggesting that the deregulation of proteins involved in neural physiology could contribute to the transformed phenotype in MB. Calsynthenin 1 (CLSTN1) is a neuronal protein involved in cell-cell interaction, vesicle trafficking, and synaptic signaling. We previously identified CLSTN1 as a putative target of the pro-invasive kinase MAP4K4, which we found to reduce CLSTN1 surface expression. Herein, we explored the expression and functional significance of CLSTN1 in MB. We found that CLSTN1 expression is decreased in primary MB tumors compared to tumor-free cerebellum or brain tissues. CLSTN1 is expressed in laboratory-established MB cell lines, where it localized to the plasma membrane, intracellular vesicular structures, and regions of cell-cell contact. The reduction of CLSTN1 expression significantly increased growth factor-driven invasiveness. Pharmacological inhibition of pro-migratory MAP4 kinases caused increased CLSTN1 expression and CLSTN1 accumulation in cell-cell contacts. Co-culture of tumor cells with astrocytes increased CLSTN1 localization in cell-cell contacts, which was further enhanced by MAP4K inhibition. Our study revealed a repressive function of CLSTN1 in growth-factor-driven invasiveness in MB, identified MAP4 kinases as repressors of CLSTN1 recruitment to cell-cell contacts, and points towards CLSTN1 implication in the kinase-controlled regulation of tumor-microenvironment interaction.
Novel approach to enhance the efficiency of mortar against radiations by co-incorporation of lead and boron compounds with calcium chloride
Authors: Al-kroom Hussein , Ouda Ahmed S. , Ramadan Wageeh , Gharieb Mahmoud , Hamsho Mudar , Abdel-Gawwad Hamdy A. 
Published: January 2025

AbstractFabrication of heavy density mortar using aggregates reinforced with available solid inorganic chemical additives is of a great importance as a protective layer to mitigate radiations in nuclear facilities. The effect of lead oxide and borax decahydrate on the hydration kinetics was evaluated by determining setting time, leachability and compressive strength. To speed up the reaction, 0.5% calcium chloride was added to all formulations, and then the results were compared to their blank counterparts. Once, the optimal compositions were explored, another batch of mortar were designed to increase efficiency against radioactive sources with different photon energies. After 28 days, bulk density, linear attenuation coefficient, half-value layer, tenth-value layer, and mean-free path in the field of 137Cs and51Co were considered. Similarly, macroscopic effective removal cross-section was evaluated using radioactive source-239Pu-α-9Be. According to the previous literature, adding 0.2% PbO to cement is the optimal ratio without affecting hydration kinetics and phase composition. The study explored that, co-incorporation of PbO with 0.5% CaCl2 increases the ratio to 2.5%, while enhancing physico-mechanical and radiological characteristics against radioactive sources. Also, formulation incorporating 0.5% borax with 0.5% CaCl2 had superior attenuation against neutrons compared to other competitors.
Thio-modified trianglimines, a novel group of chiral macrocyclic compounds of high structural dynamics
Authors: Prusinowska Natalia , Czapik Agnieszka , Szymkowiak Joanna , Kwit Marcin 
Published: January 2025

AbstractThe embellishing of the macrocycle core with sulfur substituents of varied sterical requirements changes the structural dynamics of chiral, triangular polyimines. Despite their formal high symmetry, these compounds adopt diverse conformations, in which the macrocycle core represents a non-changeable unit. DFT calculations reveal that the mutual arrangement of sulfur-containing substituents is controlled mainly by sterical interactions. The presence of sulfur atoms affects the chiroptical properties of these compounds and causes a red shift of respective absorption bands compared to the basic trianglimine. Unexpectedly, the aromatic fragments attached to the sulfur atom have less impact on ECD spectra, visible only in particular spectral regions. Such a possibility to adapt various conformations is also seen in the crystalline phase; however, a stiff basic unit – the triangular macrocycle core – caused macrocycles’ self-assembly into columnar-like aggregates. In the crystal lattice, around the macrocycle having bulky SCPh3 groups, a space filled with solvent is formed; however, the macrocycle’s internal cavity is closed and unavailable for guest molecules. Titration of the solutions of basic SBn-substituted imine and amine macrocycles by AgOTf results in significant changes in the ECD spectra, confirming possible binding interactions between macrocycle and metal cations.
Developmental beta-cell death orchestrates the islet’s inflammatory milieu by regulating immune system crosstalk
Authors: Akhtar Mohammad Nadeem , Hnatiuk Alisa , Delgadillo-Silva Luis , Geravandi Shirin , Sameith Katrin , Reinhardt Susanne , Bernhardt Katja , Singh Sumeet Pal , Maedler Kathrin , Brusch Lutz , Ninov Nikolay 
Published: January 2025

Abstract
While pancreatic beta-cell proliferation has been extensively studied, the role of cell death during islet development remains incompletely understood. Using a genetic model of caspase inhibition in beta cells coupled with mathematical modeling, we here discover an onset of beta-cell death in juvenile zebrafish, which regulates beta-cell mass. Histologically, this beta-cell death is underestimated due to phagocytosis by resident macrophages. To investigate beta-cell apoptosis at the molecular level, we implement a conditional model of beta-cell death linked to Ca2+ overload. Transcriptomic analysis reveals that metabolically-stressed beta cells follow paths to either de-differentiation or apoptosis. Beta cells destined to die activate inflammatory and immuno-regulatory pathways, suggesting that cell death regulates the crosstalk with immune cells. Consistently, inhibiting beta-cell death during development reduces pro-inflammatory resident macrophages and expands T-regulatory cells, the deficiency of which causes premature activation of NF-kB signaling in beta cells. Thus, developmental cell death not only shapes beta-cell mass but it also influences the islet’s inflammatory milieu by shifting the immune-cell population towards pro-inflammatory.
Confirmation of the planetary nebula nature of HaTr 5
Authors: Guerrero M. A. , Santamaría E. , Liberato G. , Parker Q. A. , Gonçalves D. R. , Rodríguez-González J. B. , Ritter A. , Yuan H. , Toalá J. A. 
Published: January 2025

Context. The identification of the nebula HaTr 5 with the shell remnant of the historic Nova Sco 1437 around the low-accretion rate cataclysmic variable 2MASS J17022815-4306123 has been used in the framework of the hibernation scenario to set an upper limit of ≤580 yr on the transition time from a nova-like binary to a dwarf nova.
Aims. This work is aimed at clarifying the nature of HaTr 5, which has also been deemed a possible planetary nebula in previous works.
Methods. We obtained intermediate- and high-dispersion long-slit spectra of HaTr 5 and analyzed them in conjunction with archival optical and infrared images to investigate its spectral properties using photoionization models. In addition, we sought to derive its Hα flux and ionized mass and determine its spatio-kinematic by means of 3D models to clarify its true nature.
Results. The Hα flux of HaTr 5 implies an ionized mass of 0.059 M⊙ at the 0.99 kpc distance of 2MASS J17022815-4306123, namely, ∼1000 times the typical ejecta of a nova. If HaTr 5 were actually an unrelated planetary nebula, its Hα flux would imply a distance of 2.25 kpc and an ionized mass of 0.47 M⊙. The expansion velocity of HaTr 5 is found to be ≃27 km s−1, with a heliocentric radial velocity of −1 km s−1.
Conclusions. The ionized mass of HaTr 5 and its expansion velocity (and associated kinematic age) are clearly inconsistent with those expected for a nova remnant, all strongly support a planetary nebula nature. The association of 2MASS J17022815-4306123 with HaTr 5 is further called into question based on their differing radial velocities and almost orthogonal motions on the plane of the sky. We have concluded that HaTr 5 is an old, evolved planetary nebula unrelated to the remnant of Nova Sco 1437 or to the cataclysmic variable 2MASS J17022815-4306123, with the latter being by chance projected onto HaTr 5.
Contemporary Cementless Patellar Implant Survivorship: A Systematic Review and Meta-Analysis of 3,005 Patellae
Authors: Elmenawi Khaled A. , Gonzalez-Bravo Adrian E. , Prokop Larry J. , Hannon Charles P. , Abdel Matthew P. , Bedard Nicholas A. 
Published: January 2025

AbstractHistorically, cementless patellar implants were fraught with issues of fixation and polyethylene wear. However, contemporary cementless patellar implants incorporate modern technologies for implant design and offer the potential for improved biological fixation and longevity. As such, an evaluation of the performance of modern cementless patellae is needed. The purpose of this study was to perform a systematic review and meta-analysis of contemporary cementless patellar implants used during primary total knee arthroplasty (TKA), with a particular focus on aseptic loosening of the patellar component.A systematic review of the literature was performed from January 2000 to February 22, 2024. We included all peer-reviewed studies that reported the number of revisions in patients who had cementless patellae placed in 2000 or later during primary TKA. Reviews and case reports were excluded. Out of 639 studies, 13 were included with a total of 3,005 cementless patellae analyzed. The mean patient age was 64 years and the mean body mass index (BMI) was 31 kg/m2. Meta-analyses were performed to calculate the pooled revision rate per person-year of revision for aseptic loosening of the patellar component and revision for any patellar failure.Upon analysis of 13 studies involving a total of 3,005 cementless patellae, the revision rate for aseptic loosening of the patella was 0.2 per 1,000 person-years and the revision rate for any patellar failure was 1 per 1,000 person-years.Contemporary cementless patellar implants showed an overall revision rate of 1 per 1,000 person-years, demonstrating excellent longevity. The high survivorship, together with a low rate of loosening, show the utility and effectiveness of these implants. Given the nature of biologic fixation, these results are promising for long-term implant stability but additional follow-up is warranted.
Phenomenological theory of the relaxation of spin waves in the multisublattice antiferromagnet UO2
Authors: Bar’yakhtar V. G. , Belykh V. G. , Vitebskiĭ I. M. , Soboleva T. K. 
Published: January 2025

The relaxation of optical and acoustic magnons in the multisublattice, noncollinear, antiferromagnet UO2 is studied phenomenologically, employing the equation of motion of the sublattice magnetizations. It is shown that the relaxation of optical magnons is determined by the uniform exchange interactions. The damping Pi (i = 1,2,3) of each of the three acoustic branches of the magnon spectrum is represented in the form Γi=B/2λrel +λexq2+λ1ωsi2/4BL02, where ωsi is the frequency of the corresponding branch of the spectrum, and the quantities B and λ1 are of an exchange nature.
Ultra-fast single-crystal CVD diamonds in the particle time-of-flight (PTOF) detector for low yield burn-history measurements on the NIF (invited)
Authors: Reichelt B. L. , Kishimori R. , Lawrence Y. , Wink C. W. , Johnson M. Gatu , Johnson T. M. , Adrian P. J. , Baker K. L. , Casey D. T. , Clark D. S. , Dannhoff S. G. , Eckart M. J. , Evans T. E. , Geppert-Kleinrath H. , Gibson D. , Hahn K. D. , Higginson D. P. , Izumi N. , Kabadi N. V. , Kerr S. , Kunimune J. H. , Landen O. L. , Mariscal E. , Marsh R. A. , Martinez D. , Meaney K. D. , Pearcy J. A. , Petrasso R. D. , Rubery M. S. , Rusby D. R. , Russell L. , Schlossberg D. J. , Smalyuk V. A. , Tommasini R. , Frenje J. A. , Li C. K. 
Published: January 2025

The Particle Time of Flight (PTOF) diagnostic is a chemical vapor deposition diamond-based detector and is the only diagnostic for measuring nuclear bang times of low yield (&lt;1013) shots on the National Ignition Facility. Recently, a comprehensive study of detector impulse responses revealed certain detectors with very fast and consistent impulse responses with a rise time of &lt;50 ps, enabling low yield burn history measurements. At the current standoff of 50 cm, this measurement is possible with fast 14 MeV neutrons from deuterium–tritium (DT) fusion plasmas. PTOF-inferred DT burn width numbers compare well with widths inferred from the gamma reaction history diagnostic on mid-yield (1013–1015) shots, where both systems are capable of making this measurement. These new capabilities could be extended to 2.5 MeV deuterium–deuterium neutrons from D plasmas and to even lower yield by reducing the detector standoff distance to 10 cm; a design for this is also presented.
Co-creating stories with generative AI
Authors: Cheung Lok Ming Eric , Shi Huiwen 
Published: January 2025

Abstract
Publicly available Generative Artificial Intelligence (GenAI)
tools are said to liberate students from the instrumental use of English and
empower them to write creative texts to communicate with different communities.
This paper reports on an undergraduate language-related service-learning subject
in a Hong Kong tertiary institution. In the subject, students co-created digital
stories with asylum-seeking children, in written and podcast formats, with the
help of GenAI. The qualitative content analysis of semi-structured interviews
with the students found that this experience expanded the students’ creative
potential. Meanwhile, GenAI played a peripheral role in the story creation
processes, in that the students exercised agency to use the tools and remained
critical of the AI-generated content. This study argues that digital
storytelling with GenAI, when used critically, promotes linguistic, digital and
cultural awareness among ESL learners, offering them a third space to interact
with culturally diverse communities in Hong Kong and giving them genuine
ownership of English for creative and communicative purposes.