bluuebunny/crossref_metadata_2025_split huggingface dataset:
Padua Prediction Score was Inappropriate for Venous Thromboembolism Risk Assessment in Acute Medical Inpatients: A Cohort Study
Authors: Yang Suqiao , Zhang Yixiao , Jiao Xiaojing , Liu Jiayu , Wang Wei , Kuang Tuguang , Gong Juanni , Li Jifeng , Yang Yuanhua 
Published: March 2022

Abstract
Background
Padua Prediction Score (PPS) still lacks of effectively external validation in Chinese population. To assess the accuracy of PPS to predict venous thromboembolism (VTE) risk in acute medical inpatients, and to compare the predictive value with Caprini risk assessment model (RAM).
Methods
This consecutive cohort study included acute internal medicine inpatients in Beijing Institute of Respiratory Medicine, Beijing, China from January to August 2019. The PPS and Caprini RAM were assessed for all the patients. The occurrence rate of VTE predicted by PPS and Caprini RAM was compared using Chi-squared test. Discrimination was evaluated by the area under curve using the Delong tests. Reclassification parameters were also used to compare the PPS's clinical utility with that of the Caprini RAM.
Results:
A total of 1647 inpatients of internal medicine were retrospectively registered. The overall incidence of VTE during hospitalization was 13.2%. The incidence of VTE in low-risk patients was 6.5% assessed by PPS, which was significantly higher than that by Caprini RAM (2.6%, p < 0.001). The area under the receiver operating characteristic curve (ROC) for PPS and Caprini RAM was 0.747 (95%CI, 0.725–0.768) and 0.773 (95%CI, 0.752–0.793), respectively (p = 0.0453). Based on the best cut-off, the specificity of the PPS appeared higher than that of the Caprini RAM (82.45 vs 60.07, p < 0.001), but its sensitivity was lower (59.45 vs 83.87, p < 0.001). Compared with Caprini RAM, the net reclassification index was estimated at 0.094 (p = 0.016) and integrated discrimination improvement was 0.037 (p = 0.098) by PPS. The ROC curve of the Caprini RAM and PPS in the subgroup of patients without pharmacological prophylaxis during their hospitalization was 0.776 of the Caprini RAM, which was significantly higher than that of the PPS (p = 0.005).
Conclusions
PPS seems inappropriately to predict VTE risk in acute internal medicine inpatients. It has limitations not only in the performance of identifying “VTE high-risk” patients, but also in the ability of discrimination. An accurate, widely applicable, validated RAM for prediction of the VTE risk needs to be further constructed in Chinese hospitalized medical patients.
A hierarchical spatial Durbin model (HSDM): An application to regional production efficiency in Europe
Authors: Márquez Alejandro Almeida , Hernández Julián Ramajo 
Published: March 2022

Abstract

Expanding the recent spatial econometrics literature on hierarchical models of , this work proposes an extension of the autoregressive spatial hierarchical model (HSAR) to a Durbin spatial hierarchical model (HSDM) that allows taking into account the spillovers produced in the independent variables.For this, the proposed model is estimated to analyze the production function of 263 European regions nested in 28 different countries for years 2000, 2007 and 2014. The results seem to indicate that the proposed model produces results similar to the HSAR model or improves them taking into account the influence that capitaland employment levels may have in other regions. Furthermore, this model allows analyzing the process of regional and national spillovers and, country influence on the regions.
Expression of mRNAs for DNA-methyltransferases and Histone Deacetylases in Granulosa Cells and Follicular Fluid of Women Undergoing in vitro Fertilization
Authors: Farkas Balint , Szalai Sarolta , Bódis Jozsef , Varjas Timea , Varnagy Akos , Godony Krisztina , Szenczi Agnes , Sulyok Endre 
Published: March 2022

Abstract
Background: Gene products involved in reproduction frequently undergo post-transcriptional modifications by DNA methylation and histone acetylation. The aim was to assess the predictive value of gene expression levels of DNA methyltransferases (DNMTs) and histone deacetylases (HDACs) in patients treated with in vitro fertilization (IVF). In a prospective, l clinical study 31 consecutive patients with male (n=17) or female (n=14) infertility diagnoses were enrolled. Granulosa cells (GCs) and follicular fluid (FF) were obtained at the oocytes retrieval during IVF. mRNA levels of DNMT1, DNMT3a, DNMT3b and HDAC5, HDAC6 were measured in GCs and FF by quantitative RT-PCR using ROCHE Lightcycler 480. The outcome measures were the number of oocytes retrieved, mature oocytes and viable embryos, as well as chemical and clinical pregnancy.Results: It was demonstrated that genes for DNMTs and HDACs could be detected in nearly equal amount in GC and FF, however, only the DNMT3a transcript in FF correlated with that in GC (r=0.478, p<0.033). Moreover, FF DNMT3a was significantly higher in the pregnant (N=9) than in the non-pregnant (N=22) patients (p<0.016), and HDAC6 in GC was significantly related to the number of oocytes retrieved (r=0.413, p<0.026), MII oocytes (r= 0.383, p<0.040) and viable embryos (r=0.413, p<0.025).Conclusions: In our clinical setting the expression of mRNA for FF DNMT3a and for GC HDAC6 has the potential to assess IVF outcome.
Dexmedetomidine Attenuates Hyperalgesia Induced By Brachial Plexus Root Avulsion By Restoring The GLT-1 Function Via PKA Signaling
Authors: Xu Xiaoying , Ren Zhiheng , Tang Ying , Zilundu Prince L. M. , Zhou Yingying , Li Wenfu , Hou Jiawei , Fu Yixin , Mai Yunlin , Huang Yu , Liaquats Zaara , Cheng Xiao , Ye Jiang-Hong , Zhou Li-Hua , Fu Rao 
Published: March 2022

Abstract
Background: Chronic neuropathic pain often occurs with unclear mechanisms after brachial plexus root avulsion (BPRA) injuries. Emerging evidence suggests that the maladaptation of spinal glial glutamate transporter GLT-1 causes extracellular glutamate accumulation, contributing to central sensitization of chronic pain. Dexmedetomidine (DMET), an α2-adrenergic receptor (α2AR) agonist, widely used in the clinic as a sedative and analgesic drug, has been shown to inhibit glial activation. This study assessed DMET effects on BPRA induced pain and the possible involvement of GLT-1 regulation. Methods: The right C8 and T1 roots were avulsed to establish a lower trunk BPRA injury rat model and LPS-induced activation of rat primary cultured astrocytes. Then we used the molecular and behavioral assay combined with pharmacological manipulation to test the hypothesis that DMET attenuates the pain and neuroinflammation through restoring the GLT-1 function via PKA signaling.Results: The mechanical allodynia and thermal hyperalgesia appeared and reached the peak at 1-day post-injury (dpi) and persisted for at least 28 dpi. Notably, BPRA enhanced phosphorylated PKA levels, reduced GLT-1 expression, and caused an imbalance between anti- and proinflammatory cytokines in the affected spinal segments. Acute systemic or local DMET administration, at the un-sedative doses, demonstrated an analgesic effect. Moreover, a 3-days intrathecal DMET treatment ameliorated hyperalgesia and allodynia of BPRA injured rats by attenuating PKA phosphorylation, IL-1β, and IL-6, while restoring the levels of GLT-1, IL-4, and IL-10 in the spinal cord. Significantly, intrathecal administration of the selective PKA inhibitor H89 mimicked, but the PKA activator 8-Br-cAMP blocked DMET’s effects. Conclusion: Overall, these results suggest that PKA inactivation mediates DMET's analgesic effect for the pain induced by BPRA injury through the recovery of GLT-1 function.
Analysis of complex chromosomal rearrangements using a combination of current molecular cytogenetic techniques
Authors: He Ping , Wei Xiaoni , Xu Yuchan , Huang Jun , Tang Ning , Yan Tizhen , Yang Chuanchun , Lu Kangmo 
Published: March 2022

Abstract
Background
Using combined fluorescence in situ hybridization (FISH) and high-throughput whole genome sequencing (WGS) molecular cytogenetic technology, we aim to analyze the junction breakpoints of complex chromosome rearrangements (CCR) that were difficult to identify by conventional karyotyping analysis and further characterize the genetic causes of recurrent spontaneous abortion.
Results
By leveraging a combination of current molecular techniques including chromosome karyotype analysis, FISH and WGS, we were able to fully characterize the extremely complex chromosomal abnormalities in this patient with recurrent spontaneous abortions. Here, we demonstrated that combining these current established molecular techniques is an effective and efficient workflow to identify the structural abnormalities of complex chromosomes and locate the rearrangement of DNA fragments.
Conclusions
In conclusion, leveraging results from multiple molecular and cytogenetic techniques can provide the most comprehensive genetic analysis for genetic etiology research, genetic diagnosis and genetic counseling for patients with recurrent spontaneous abortion and embryonic abortion.
Surveillance of Russell Body Inflammation of the Digestive Tract: A Case Report and Review of Literature
Authors: Luo Shuai , Huang Xiang , Li Yao , Wang Jinjing 
Published: March 2022

Abstract
Introduction: Russell body inflammation of the digestive tract (RBIDT) is a rare chronic inflammation of the digestive tract mucosa that commonly presents as Russell body gastritis (RBG). This disease is usually associated with Helicobacter pylori (HP) infection. However, it can also occur in individuals without HP infection and with specific immune profiles, as seen in HIV and hepatitis C infections. The aetiology and pathogenesis of this disease remain controversial. Given the rarity of the disease and the diversity of the immunophenotypes, there is a high probability of misdiagnosis.Case Presentation: A male patient with RBG and HP infection was included in this study. The case of RBG with an unusual morphology of Mott cells that mimics stamped ring cells.Endoscopy performed during the follow-up revealed regression of the lesion 1 week after anti-HP treatment.Conclusion: A case of RBG with a high likelihood of misdiagnosis of signet ring cell carcinoma (SRC) has been reported in this study along with a review of the relevant literature and an overview of RBIDT.
Compulsory insurance within the framework of the Bank of Russia's Mortgage Regulation Concept
Authors: Жукова О.В. 
Published: March 2022

Банком России, во исполнение поручения Президента РФ от 02.04.2020 № Пр-612 о принятии мер по снижению полной стоимости ипотечных жилищных кредитов, одной из составляющих которой являются расходы на страхование, разработана «Концепция регулирования ипотечного страхования». Суть «Концепции» заключается в том, что, после внесения изменений в федеральный закон, страхователем будет выступать не заёмщик-залогодатель, а банк-кредитор выгодопреобретатель или ипотечный агент. Заёмщик должен будет ежемесячно погашать дополнительно 1,0% от суммы кредита в порядке компенсации расходов банка на страхование
The Bank of Russia, pursuant to the instruction of the President of the Russian Federation No. Pr-612 dated 02.04.2020 on taking measures to reduce the full cost of mortgage housing loans, one of the components of which is insurance costs, has developed a «Concept for regulating mortgage insurance», which has been discussed at the level of the professional community, and is currently in the Government of the Russian Federation. The «concept» concerns insurance accompanying the pledge of immovable property arising on the basis of the federal law (mortgage by virtue of the Law) dated 16.07.1998 No. 102-FZ «On Mortgage (pledge of real estate)» and by virtue of the mortgage agreement, as well as personal life and health insurance of the borrower, the essence of which is that, after amendments to the federal law, the policyholder will not be the borrower-mortgagor, but the lender-beneficiary bank or mortgage agent. This is another step towards housing affordability, as the amount of the first lump-sum payment when applying for a mortgage loan and subsequent annual deductions decreases, since the borrower will have to pay insurance premiums in installments for the entire period of the mortgage insurance contract as a percentage, depending on the amount of the mortgage loan.
The use of modern trends in the use of information technologies in improving the efficiency of the agricultural and industrial complex of the north caucasus federal district
Authors: Балиянц К.М. , Дохолян С.В. 
Published: March 2022

Цифровое развития АПК региона возможно на основе изучения зарубежного опыта и опыта передовых регионов РФ, выявления препятствий и условий для его активного внедрения в хозяйствах. Основными направлениями, способствующими развитию цифровизации АПК региона выделены: подготовка и переподготовка кадрового состава агросферы региона среднего и высшего звена, развитие широкополосного интернета и сотовой связи в сельской местности, доступное финансовое обеспечение инновационных проектов в АПК, налоговые и кредитные льготы для предприятий внедряющих новые технологии.
Digital development of the agro-industrial complex of the region is possible on the basis of studying foreign experience and the experience of advanced regions of the Russian Federation, identifying obstacles and conditions for its active implementation in farms. The main directions contributing to the development of digitalization of the agro-industrial complex of the region are: training and retraining of the personnel of the agro-sphere of the region of middle and senior management, the development of broadband Internet and cellular communications in rural areas, affordable financial support for innovative projects in the agro-industrial complex, tax and credit benefits for enterprises implementing new technologies. Agro-industrial complex, digital development of the region, North Caucasus Federal District.
The system-forming role of the Arctic cluster in the developmentof the economy of the North of Russia(on the example of the Murmansk region)
Authors: Лычкина Л.С. , Хаценко Е.С. 
Published: March 2022

Представленная статья посвящена оценке состояния и перспективам развития кластерных инициатив, как основе пространственного развития Арктической зоны Российской Федерации; сделан анализ стратегического развития и направлений кластерной политики циркумополярных регионов и произведена оценка кластерного потенциала перспективных отраслей Арктической зоны РФ.
The presented article is devoted to the theoretical and legal aspects of the formation of the economic policy of the Russian Arctic, the creation and regulation of the Arctic economic cluster.
Mechanical activation of zirconium with a degradable polymer in various atmospheres
Authors: Титова В.А. , Рева В.П. 
Published: March 2022

В статье рассмотрены механохимические процессы, реализуемые в результате механоактивации циркония совместно с деструктируемым полимером при использовании различных рабочих атмосфер. Рассмотрен фазовый состав порошковых материалов.
The article discusses the mechanochemical processes realized as a result of mechanical activation of zirconium with a degradable polymer using different working atmospheres. The phase composition of powder materials is considered.
Deadbeat two-vector model predictive current control for open-winding primary permanent-magnet linear motor
Authors: Tang Hongyu , Sha Ou , Yang Zhenli , Xu Dezhi 
Published: March 2022

The structure of open-winding motor fed by the dual-inverter can increase the winding terminal voltage of the primary permanent-magnet linear motor (PPMLM). So, it is an effective method to improve the thrust performance of the PPMLM. Based on the detailed derivation of the mathematical model of the open-winding PPMLM and the in-depth analysis of the space voltage vector distribution characteristics of the dual-inverter, a deadbeat two-vector model predictive current control (MPCC) model is proposed in this paper. First, the optimal vector of the inverter 1 is determined by judging the position of the large sector. Second, two optimal vectors of the inverter 2 is determined by judging the position of the small sector. Finally, the duty cycle of the two optimal vectors of the inverter 2 is calculated to realize the proposed deadbeat two-vector MPCC algorithm. Compared with the traditional model predictive torque control (MPTC) and MPCC strategies, the proposed algorithm has the advantages of lower current harmonics (lower 34 % and 44 % under rated conditions, respectively) and better thrust performance (higher 77 % and 61 % under rated conditions, respectively) as well as lower computational complexity. Simulation and experimental results show that the proposed two-vector MPCC has good steady-state and dynamic performances, which can reduce the current harmonics and thrust ripple, and thus improve the motor drive performance compared with the traditional method.
Evaluation of four bias correction methods and random forest model for climate change projection in the Mara River Basin, East Africa
Authors: das Priyanko , Zhang Zhenke , Ren Hang 
Published: March 2022

Abstract
This study evaluates the performance of four bias correction methods based on CORDEX (coordinated regional climate downscaling experiment) domain six regional climate models (RCMs) at the Mara River Basin. A suitable bias correction method was considered to develop the future climate scenario. The performance of bias correction methods was evaluated by various statistical metrics based on the historical period and revealed that the distribution mapping (DM) techniques have strong performance under the different climatic conditions. The effectiveness of the DM method is found to be better at capturing the coefficient of variation and standard deviation of observed rainfall and temperature. Therefore, this study considers the future climate (2026–2095) from bias-corrected RCMs output using DM techniques. The results from bias-adjusted RCMs show an increase of rainfall (+118.3%) and temperature (+2.91) in the future climate under Representative Concentration Pathways (RCPs) 2.6, 4.5 and 8.5. In addition, this study tested the random forest (RF) method to determine the capacity of each bias-corrected RCMs for reproducing the future rainfall and temperature under the RCP 4.5 and RCP 8.5 scenario. The results demonstrate that the RF can reproduce the climate variable with its average correlation (R2) of 0.93 for rainfall and 0.95 for temperature.
Measurements of boron concentration from rivers in northern Basrah Governorate using SSNTDs
Authors: Algrifi Mostafa A. , Salman Thaer M. 
Published: March 2022

Abstract
Consumption of boron-contaminated food and drinking water poses several health risks to consumers. As a result, the boron content in food particles must be measured. Drinking water samples were obtained from several locations in northern Basrah, Iraq, for this investigation. The Solid State Nuclear Track Detector (SSNTDs) technique was used to examine the obtained water samples to identify boron levels. Boron levels were found to range from 0.28 ppm in Al Alwa (Al Qurnah) (tap water) to 1.85 ppm in Oil Street. This study's findings were compared to international standard values and previously published research. These findings may be utilized by the Iraqi government to develop guidelines to decrease radioactive contamination of drinking water in Basrah. The 41 surface water samples tested in this study had boron levels that were lower than the international standard limits. As a result, the boron level in Basrah's drinking water is normal. However, there is a chance that boron contamination will become a serious concern shortly. As a result, additional research is required in the future.
MPTP as a Molecular Paradigm for Neurodegeneration. A Review of its Connections with Relevant Molecules
Authors: Vidaluc Jean-Louis 
Published: March 2022

Abstract:
The parkinsonian neurotoxin MPTP was reviewed with special interest in its structural features including close analogs and its biological connections with relevant molecules able to reverse or protect against its neurotoxic effects. Thus, some fifty efficient molecules displaying structural diversities and affinities towards a number of receptors with variable known implications in neurodegenerative diseases or in the neurotoxicity of MPTP, were highlighted.
The Epidermal Growth Factor Receptor Family of Tyrosine Kinases and Cancer: Can An Atypical Exemplar Be A Sound Therapeutic Target?
Authors: Bridges A. J. 
Published: March 2022

Abstract:
Epidermal Growth Factor (EGF) receptor was the first peptide growth hormone receptor found to contain an intracellular tyrosine kinase. It is frequently used to exemplify the properties of the whole family of receptor
tyrosine kinases. Much work has been done on EGFr to elucidate the mechanisms of activation
of RTKs, and their coupling to downstream signaling processes. The type I RTKs consist of four closely related RTKs, and a bewildering number of ligands. The number of ligands is not typical for RTKs, but the discovery that this family can form signaling-competent heterodimers as well as homodimers may explain this abundance. The type I RTKs are almost ubiquitous in solid neoplasias, as 90% of clinical samples express at least one family member, and at least 60% of tumours overexpress at least one of the receptors or cognate growth factors. Overexpression correlates with poor prognosis and shorter survival times. The high prevalence suggests that type I RTKs may activate more transforming signaling pathways that most other RTKs. Both the high prevalence, and the importance of the EGFr family to the transformed phenotype, suggest that inhibition of their signaling will have therapeutic utility. This has been investigated by finding blocking antibodies for the ligand binding domains of the receptors, enzyme inhibitors for the tyrosine kinases of the family and inhibitors of downstream signaling. The enzyme inhibitor approach has led to small molecule enzyme inhibitors of great potency and selectivity for the EGFr tyrosine kinase.