bluuebunny/crossref_metadata_2025_split huggingface dataset:
Converting animated image colors into product colors: An eye- tracking technology and MLP-based color matching design method
Authors: Hua Yinhong , Ni Jianlin , Lu Honglei 
Published: October 2022

Abstract
Images are a significant source of inspiration for designers to carry out the color design. However, the absence of animated images in the product color design can create confusion for designers. To convert animated image colors to product colors, this work a hybrid method of using the eye-tracking technology to assist color extraction and an intelligent algorithm to screen out the best color scheme. Firstly, the eye-tracking technology is adopted to collect the hot spot distribution of subjects while watching the animated images. According to the eye movement hot spot distribution, the most interesting animated color is extracted. And then, with the help of multilayer perceptron neural network, the color design of three-color children’s shopping cart product is carried out on the extracted animated color. Experimental results show that the color extraction based on the eye-tracking technology and the color scheme screening based on the intelligent algorithm can realize the effective conversion from animated image colors to product colors. This work proposes a color scheme design method from animations to products, which further expands the image color sources in product color design and can quickly and accurately find the color scheme that matches the animated image and the product.
Axial Involvement in Enthesitis-Related Arthritis: Results from a Single-Center Cohort
Authors: Guo Yanli , Fang Yuying , Zhang Tonghao , Pan Yuting , Wang Panpan , Fan Zhidan , Yu Haiguo 
Published: October 2022

Abstract
Background: Axial involvement in children with enthesitis-related arthritis (ERA) has characteristics that differ from those of peripheral involvement. This study characterized their clinical characteristics and treatment.
Methods: Patients with ERA at the Children’s Hospital of Nanjing Medical University between January 2018 and December 2020 were included. The ERA cohort was divided into two based on the presence or absence of axial joint involvement. Demographic characteristics, clinical features, and treatments were described and compared.
Results: In total, 105 children with ERA were enrolled (axial ERA, n=57; peripheral ERA, n=48). The age at disease onset of the axial group tended to be higher (11.93 ± 1.72 vs. 11.09 ± 1.91 years) and the diagnosis delay was bigger in patients with axial ERA (10.26 ± 11.66 months vs. 5.13±7.92 months). The inflammatory marker levels were significantly higher in patients with axial. There were no differences in HLA-B27 positivity between the groups (34 [59.65%] vs. 28 [58.33%], P>0.05). Hip involvement was more frequent in the axial group (52.63% vs 27.08%; X2=7.033). A total of 38 (66.67%) and 10 (20.83%) patients with axial and peripheral ERA, respectively, were treated with biological disease-modifying anti-rheumatic drugs (DMARDs) at diagnosis. The administration of biologics increased gradually in the axial ERA group, peaking at 18 months and decreasing thereafter, whereas that in the peripheral ERA group peaked at 6 months and began to decline thereafter.
Conclusions: Axial ERA is a persistent active disease and requires a more aggressive treatment. Classification and early recognition of axial involvement may help with timely diagnosis and appropriate management.
Spatial identification and multilevel zoning of land use functions improve sustainable regional management: A case study of the Yangtze River Economic Belt, China
Authors: Gao Yunxiao , Wang Zhanqi , Zhang Liguo , Chai Ji 
Published: October 2022

Abstract
The quantitative identification and zoning management of land use functions (LUFs) are important starting points for solving the problems of resource allocation and sustainable development. In this study, with the Yangtze River Economic Belt (YREB) as a case study area, LUFs were grouped into three primary categories: economic function (ENF), social function (SCF), and ecological function (ELF). The least square error model was adopted to identify the morphological changes of LUFs. A two-dimensional discriminant matrix of the dynamic degree of LUF change and terrain niche index was constructed to explain the terrain gradient effect of LUFs. Bivariate local spatial autocorrelation was used to analyze the trade-offs in 2018 between ELF and ENF, and ELF and SCF. Finally, a new multilevel zoning scheme for LUFs was proposed. The results showed that from 1990 to 2018, ENF increased rapidly in cities along the Yangtze River, the overall level of SCF declined, and ELF in the south of the Yangtze River was better than that in the north. LUFs’ morphological zoning exhibited significant regional differences. SCF-ELF combination areas and ELF dominance areas were mainly optimized in the second-level zoning. The areas with weak ELF were concentrated in the east of the YREB. Based on these results, nine kinds of LUF zonings and six kinds of major functional zonings were devised, and policy allocation was arranged for each zoning to improve the efficiency of spatial zoning management. Our research provides a reference for large-scale regional sustainable development and land use zoning management.
Chemoproteomic Mapping of Glycolytic Targetome in Cancer Cells
Authors: Hao Haiping , Tian Yang , Wan Ning , Zhang Hanqing , Shao Chang , Ding Ming , Bao Qiuyu , Hu Haiyang , Sun Huiyong , Zhou Kun , Chen Shuai , Wang Guangji , Ye Hui 
Published: October 2022

Abstract
Hyperactivated glycolysis is a metabolic hallmark of most cancer cells. Although sporadic information has revealed that glycolytic metabolites possess non-metabolic functions as signaling molecules, it remains largely elusive how these metabolites interact with and functionally regulate their binding targets. Here we introduce a Target Responsive Accessibility Profiling (TRAP) approach that measures ligand binding-induced accessibility changes for target identification through globally labeling reactive proteinaceous lysines. With TRAP, we mapped 913 target candidates and 2,487 interactions for 10 major glycolytic metabolites in a model cancer cell line. The wide targetome depicted by TRAP unveils diverse regulatory modalities of glycolytic metabolites involving direct perturbation of carbohydrate metabolism enzymes, intervention of orphan transcriptional proteins’ interactions, and modulation of targetome-level acetylation. These results deepen our understanding of how glycolysis orchestrates signaling pathways in cancer cells in support of their survival and inspire the exploitation of the glycolytic targetome for cancer therapy development.
Blood-brain barrier permeability and increased levels of amino acids in cerebrospinal fluid are associated with brain alterations in rats with acute liver failure
Authors: Guazzelli Pedro Arend , Fachim Felipe dos Santos , Travassos Anderson Santos , Schaukoski Caroline Casagrande , Ferreira Pâmela Cristina Lukasewicz , Fontella Fernanda Uruth , de Assis Adriano M , Souza Diogo Onofre 
Published: October 2022

Abstract
Acute liver failure (ALF) is a life-threatening medical condition that often leads to hepatic encephalopathy (HE). Animals and humans with HE have shown elevated cerebrospinal fluid (CSF) levels of glutamine and glutamate, which may be associated with brain impairment. In this study, we aim to evaluate the relationship between blood-brain barrier (BBB) integrity and CSF amino acid levels with the neurological status of rats after subtotal hepatectomy. Adult male Wistar rats underwent a subtotal hepatectomy (removing 92% of hepatic mass or SHAM group) and were divided into 4 (four) cohorts. Animals with ALF presented severe neurological impairment and high mortality rates when compared to the SHAM group (Cohort 1). We performed a hepatic function test 24 hours after subtotal hepatectomy, which demonstrated a significant increase of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Total Bilirubin, Direct Bilirubin, Prothrombin time and Ammonia levels in blood (Cohort 2). Additionally, the increase of amino acids, glutamine, and albumin levels in CSF as well as of Evans Blue penetration into the brain tissue was correlated with the neurological grades of HE, indicating signs of impaired BBB permeability induced by ALF (Cohort 3). Furthermore, the animals’ mortality rate showed a positive correlation with the increase of amino acid levels in CSF following subtotal hepatectomy (after 12h, Cohort 4). Our data highlight the potential role of amino acid levels in CSF, especially glutamine, for detection purposes even in the early stages of HE and suggest that these molecules offer prognostic value for patients progressing to coma and death.
Prediction of bolt missing fault for multistage rotor by experimental test and analysis
Authors: YUE Cong , CHI Huashan , FAN Jianyu , ZHENG Xiangmin , ZHANG Ziling 
Published: October 2022

Abstract
The high-pressure rotor of aero-engine is assembled by numerous bolts under high manufacture precision. The connected structure is subjected to both axial force and transverse vibration during service, which may result in individual bolt loosen. In this study, the influence of bolt missing on the dynamic characteristics is analyzed by numerical simulation. A test rig capable of impact and frequency sweeping experiment under axial tension was constructed. The vibration response features in the simulation were then extracted. The loss function of the mean absolute error and the decision method of extreme gradient boosting were used to predict the bolt missing position. The results show that the proposed model can reach a prediction precision of more than 90%. Moreover, the coefficient of determination evaluation index of the prediction effect reaches 0.9, which is significantly higher than those of other conventional models such as multivariate linear regression and multivariate adaptive regression spliness.
Levels, sources, and risk assessment of PAHs residues in soil and plants in urban parks of Northwest China
Authors: Zhong Naifu , Zhou Xiaolong , Ailijiang Nuerla , Mamat Anwar , Chang Jiali , Cao Shuangyu , Hua Zhenyu , Li Nanxin 
Published: October 2022

Abstract
Using eight typical parks in Urumqi in Northwest China as the study area, we detected the content of polycyclic aromatic hydrocarbons (PAHs) in park topsoil and 10 common plants in the park during different seasons. The results showed that the content of PAHs in park soil in the summer was 5–6 times that in the winter, and the monomer PAHs in some park soil sampling points were higher than the soil pollution risk screening value. Compared with other areas, pollution is more serious. In summer, the plants with high PAHs content in leaves are short herbs, while in winter, they are tall arbors. The composition of park soil PAHs is mainly from the source of the HMW as the source of traffic. The proportion of the LMW in the winter was significantly higher than that in the summer. The source of plants in the summer is similar to that of the soil; whereas the source of plants in the winter is more complicated. The TEQ values of soil PAHs in South Park, Zhiwu Park, Shihua Park and Toutunhe Park were higher. The NIPI values of some sampling points in these four parks in the summer were relatively high. The average ILCRs of adults and children in all parks reached a low-risk level in summer. The carcinogenic risk in children is much higher than that of adults.
One step thoracotomy approach for atrial-esophageal fistula repair without cardiopulmonary bypass
Authors: Lee June , Yoon Jeashin , Hong Seok Beom , Kim Yong Han , Kim Hwan Wook , Kim Do Yeon 
Published: October 2022

Abstract
Although atrial-esophageal fistula is an extremely rare disease, it is a life-threatening complication after catheter ablation for atrial fibrillation. There is no consensus on management or repair
for atrial-esophageal fistula which has a high mortality rate. Here, we describe a lateral thoracotomy approach focused on simplifying the repair procedure for atrial-esophageal fistula with two cases.
Two male seniors in their 60s and 70s, respectively, who had undergone catheter ablation for atrial fibrillation presented to the emergency department with fever and mental decrease. Blood culture confirmed Streptococcal bacteremia. Brain magnetic resonance imaging showed multiple cerebral infarcts. After demonstrating atrial-esophageal fistula with computed tomography of chest, an emergency operation was planned.
The two patients were placed in the right down decubitus position with single lung ventilation. A lateral thoracotomy was performed on the left 5th intercostal space. Multiple pledgeted 4-0 prolene sutures for ligation were paced on the fistula of the pericardial side. From the esophageal side, a fistulectomy was performed, followed by an additional primary repair for the esophageal defect. Follow-up endoscopy demonstrated a well-repaired fistula site. The two patients were discharged without recurrence.
Our experience suggests that one step repair for atrial-esophageal fistula via lateral thoracotomy might be feasible in selected patients.
Mechanistic Analysis of Nanocellulose Formation Tuned by Deep Eutectic Solvents
Authors: Bi Xuerong , Guo Jiansheng , Wen Jin , Yu Chongwen 
Published: October 2022

Abstract
Clean energy and green solvents have attracted wide attention due to their non-toxic, biodegradable, and recyclable properties. Deep eutectic solvents (DESs), as a green solvent, have advantages in the formation of nanocellulose. To reveal the formation mechanism during cellulose nanocrystal (CNC) formation, different carboxylic acid DESs are compared in the optimal experimental conditions. Experimental observations show that oxalic acid (OA) DES can fabricate CNC with higher yield, higher crystalline index than that of citric acid series. Moreover, crystal water molecules in DES promote the reaction activity of DES in the CNC formation. To understand the interaction among the DES-cellulose complex, molecular dynamics simulations and quantum chemical calculations were applied to investigate the arrangement of CNC in the atomic scale. The analysis of the radial distribution function and intermolecular interactions indicate that the non-covalent intermolecular interactions between DES and cellulose are strong, which could be further enhanced by the crystal waters in DES. Reaction pathways during the formation of CNCs were revealed by computational simulations, which show that OA is more prone to react with cellulose in esterification and acidolysis reactions. Both computational and experimental results demonstrate that the OA DES is more beneficial in the production of CNC. The synergistic effects of chemical reactions and non-covalent interactions favor the formation of CNCs by DESs.
Structure and proteomic analysis of the crown-of-thorns starfish (Acanthaster planci cf. solaris) radial nerve cord
Authors: Smith Meaghan K. , Rotgans Bronwyn A. , Lang Tomas , Johnston Ryan , Wang Tianfang , Suwansa-ard Saowaros , Bose Utpal , Satoh Nori , Egertova Michaela , Hall Michael R. , Bryne Maria , Elphick Maurice R. , Motti Cherie A. , Cummins Scott F. 
Published: October 2022

Abstract
The nervous system of the Asteroidea (starfish or seastar) consists of radial nerve cords (RNCs) that interconnect with a ring nerve. Despite its relative simplicity, it facilitates the movement of multiple arms and numerous tube feet, as well as regeneration of damaged limbs. Here, we investigated the RNC ultrastructure and its molecular components within the of Pacific crown-of-thorns starfish (Acanthaster cf. solaris), a well-known coral predator that in high-density outbreaks has major ecological impacts on coral reefs. We describe the presence of an array of unique small bulbous bulbs (40–100 µm diameter) that project from the ectoneural region of the adult RNC. Each comprise large secretory-like cells and prominent cilia. In contrast, juvenile A. cf. solaris and its congener Acanthaster brevispinus lack these features, both of which are non-corallivorous. We hypothesise that adult neural bulbs might be an adaptation to corallivory. Proteomic analysis of the RNC (and isolated neural bulbs) provides the first comprehensive echinoderm protein database for neural tissue, including numerous secreted proteins associated with signalling, transport and defence. The neural bulbs contained several neuropeptides (e.g., bombyxin-type, starfish myorelaxant peptide, secretogranin 7B2-like, Ap15a-like, and ApNp35) and Deleted in Malignant Brain Tumor 1-like proteins. In summary, this study provides a new insight into the novel traits of A. cf. solaris, a major coral pest, and a proteomics resource that can be used to develop (bio)control strategies and understand molecular mechanisms of regeneration.
Comparison of the efficacy of different surgical approaches for complicated impacted proximal ureteric calculi based on a new scoring standard : a matched-pair analysis
Authors: Zhang Lv Wen , Fei Xiang , Song Yan 
Published: October 2022

Abstract
Objective: To compare the clinical efficacy of Ureteroscopic lithotripsy (URSL) and percutaneous nephrolithotomy (PCNL) in the treatment of complicated impacted proximal ureteric calculi based on a new scoring standard.
Methods: The data of 45 patients with complicated impacted proximal ureteric calculi underwent URSLwere collected in this retrospective study between January 2015 and April 2021. During the same period, PCNL was used in 171 patients with complicated impacted proximal ureteric calculi. 45 patients were selected as the control group and matched at a 1:1 ratio to index URSL cases in regards to age, sex, BMI. Peri-operative data were compared between the two groups.
Results: All 90 operations were successfully completed. Compared to the URSL group, the surgical duration of the PCNL group was significantly shorter (53.69 ± 25.07 min vs. 73.46 ± 27.12 min, p < 0.05), stone-free rate (SFR) was significantly higher(93.3% vs. 68.9%, p < 0.05), and total treatment cost was lower (US $1678.61 ± 714.86 vs. US $3901.45±1069.46, p < 0.05). Conversely, the URSL group had a shorter hospital stay (3.68 ± 2.70 d vs. 6.39 ± 3.34 d, p < 0.05). There was significant difference in complication rate between the two groups in regards to Clavien grade I, II, or III complications (20.0% in URSLgroup vs. 8.9% in PCNL group, p=0.32).
Conclusion: PCNL had a better SFR and higher surgical efficacy, whereas URSL had a shorter perioperative period, but a lower initial SFR. PCNL is often more advantageous for complicated impacted proximal ureter stone.
Associations Between Missing Teeth and The Risk of Cancer in Korea: A Nationwide Cohort Study
Authors: Kang Eun Joo , Moon Seok-joo , Lee Kyoungmin , Park In Hae , Kim Jung Sun , Choi Yoon Ji 
Published: October 2022

Abstract
Background
Poor dental health is correlated with an increased risk of cancer. Using a nationwide population cohort database, we investigated which cancer is highly associated with poor dental health and which dental indicator mostly influences cancer risk.
Methods
This study was conducted using the National Health Checkups (NHC) and National Health Insurance System (NHIS) database in Korea. NHC in Korea includes dental examinations. We retrieved subjects who underwent NHC between 2002 and 2003 and their medical information in NHIS database was followed until December 31,2015.
Results
Data for 200,170 who participated in the NHC between 2002 and 2003 were analysed. During the maximum follow-up period of 13 years, 15,506 (7.75%) subjects were diagnosed with cancer. The median time to cancer diagnosis after the dental examination was 87 months (range, 51–119 months). The proportion of people with missing teeth was higher in the cancer-diagnosed group than in the non-diagnosed group (26.27% vs. 22.59%, p<0.001). Among several dental health factors, missing teeth were significantly associated with higher cancer risk. Subjects with missing teeth showed a 12% increased cancer risk compared to those without missing teeth (odds ratio [OR] 1.12, 95% confidence interval [CI], 1.08–1.16). The risk was significantly higher, especially in lung, head and neck, pancreatic, liver, biliary, and esophageal cancers (OR 1.27 [95% CI, 1.14–1.41], 1.32 [95% CI, 1.13–1.55], 1.27 [95% CI, 1.02–1.58], 1.24 [95% CI, 1.1–1.4], 1.28 [95% CI, 1.03–1.6], 1.4 [95% CI, 1.04–1.88], respectively).
Conclusions
Missing teeth were the most important dental indicator associated with cancer risk. Korean adults with missing teeth should be cautious about the risk of severalcancers, particularly head and neck, lung, gastrointestinal, hepatobiliary, and pancreatic cancer.
Itaconic acid underpins hepatocyte lipid metabolism in non-alcoholic fatty liver disease
Authors: Weiss Jonathan , Palmieri Erika , Gonzalez-Cotto Marieli , Bettencourt Ian , Megill Emily , Snyder Nathaniel , McVicar Daniel 
Published: October 2022

Abstract
Itaconate, the product of the decarboxylation of cis-aconitate, regulates numerous biological processes. We and others have revealed itaconate as a regulator of fatty acid beta-oxidation, generation of mitochondrial reactive oxygen species and the metabolic interplay between resident macrophages and tumors. In the present study, we show that itaconic acid is upregulated in human non-alcoholic steatohepatitis and a mouse model of non-alcoholic fatty liver disease. Mice deficient in the gene responsible for itaconate production (Immunoresponsive gene /Irg-1) have exacerbated lipid accumulation in the liver, glucose and insulin intolerance and mesenteric fat deposition. Treatment of mice with the itaconate derivative, 4-OI, reverses dyslipidemia associated with high fat diet feeding. Mechanistically, itaconate treatment of primary hepatocytes reduces lipid accumulation and increases their oxidative phosphorylation in a manner dependent upon fatty acid oxidation. We propose a model whereby macrophage-derived itaconate acts in trans upon hepatocytes to modulate the liver’s ability to metabolize fatty acids.
Impact of permafrost degradation on the extreme increase of dissolved iron concentration in the Amur River during 1995–1997
Authors: Tashiro Yuto , Hiyama Tetsuya , Kanamori Hironari , Kondo Masayuki 
Published: October 2022

Abstract

Dissolved iron (dFe) concentration in the Amur River increased considerably between 1995 and 1997, but the mechanisms of dFe discharge to the Amur River are poorly understood. We examined the long-term changes in climate variables in the Amur River basin between 1960 and 2000; net precipitation in late summer (July–September) has increased since 1977 throughout the basin; annual air temperature (Ta) was relatively high between 1988 and 1990. Most importantly, we found significant correlations between Ta and dFe concentration with a 7-year lag (r = 0.43–0.55, p < 0.01), which indicate a close relationship between high Ta in year Y and increased dFe concentration in year Y + 7. Correlation was the strongest in northeastern Amur basin where permafrost coverage is the highest. On the basis of our findings, we propose that (1) increased net precipitation since 1977 has increased soil moisture, which created favourable conditions for microbial iron reduction; (2) permafrost degradation during the warm years of 1988–1990 promoted iron bioavailability and led to the intensive generation of dFe in the deeper part of the active layer; and (3) dFe took approximately 7 years to reach the rivers and increased dFe concentration during 1995–1997.