bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Clinical Outcomes Associated With the Veterans Health Administration’s Traumatic Brain Injury and Mental Health Screens
Authors: Miles Shannon R. , Toyinbo Peter A. , Belanger Heather G. , Venkatachalam Hari H. , Luther Stephen L. , Sayer Nina A. 
Published: February 2025

Objective: Examine if the mandated Veterans Affairs traumatic brain injury (TBI) screen is associated with long-term postconcussive symptoms as compared to how the mandated mental health (MH) screen is associated with long-term MH symptoms. Setting: Veterans Health Administration. Participants: Patients (N = 1628) who were previously screened for TBI with current postconcussive symptoms and MH conditions completed a survey assessing current postconcussive symptoms, depression, posttraumatic stress disorder, alcohol use, and physical and emotional well-being. Participants were mostly male (83%), less than 40 years old (38%), and identified as White (64%). Forty-five percent screened positive for MH conditions; 11% screened positive for TBI. Design: Cohort survey study of random sample of post-9/11 veterans combined with retrospective database analysis. Bayesian Network Analysis was used to compare how the TBI and MH screens related to long-term postconcussive and MH symptoms. The pathway on the Bayesian Network graph leading to postconcussive symptoms was thoroughly examined with a regression. Main Measures: Neurobehavioral Symptom Inventory to measure postconcussive symptoms. Results: A Bayesian network arch demonstrated TBI screening was related to use of TBI services within 6 months after the screening but not related to long-term postconcussive or MH symptoms. In comparison, the MH screen led to post-screen MH services, postconcussive symptoms, and most of the other secondary outcomes, including posttraumatic stress disorder and depression. The regression model showed that a positive MH screen, more MH service use, negative life events, and moderate depression were associated with greater postconcussive symptoms years after screening. Conclusion: While both TBI and MH screening were associated with increased service use, only the MH screen was associated with long-term postconcussive symptoms. Findings raise questions about whether the TBI screening program adds value over and above the MH screening program.
Experimentally induced central sensitization is accompanied by alterations in electroencephalographical microstate parameters
Authors: Jaltare Ketan Prafull , Torta Diana M. 
Published: February 2025

Abstract
Pain perception is a dynamic and time-varying phenomenon. The high temporal resolution of electroencephalography (EEG) can be leveraged to gain insight into its cortical dynamics. Electroencephalography microstate analysis is a novel technique that parses multichannel EEG signals into a limited number of quasi-stable topographies (microstates) that have a meaningful temporal structure and have been linked to the activity of resting state networks. In recent years, several studies have investigated alterations in EEG microstate parameters associated with acute and chronic pain states, with mixed results. In the present study, we used high-frequency stimulation (HFS), in healthy human volunteers, to induce mechanical hypersensitivity (a perceptual correlate of central sensitization) and investigated (1) changes in microstate parameters before vs after the induction of mechanical hypersensitivity and (2) whether microstate parameters before HFS were linked to the development of mechanical hypersensitivity. Results showed that the duration of microstate E, typically related to the activity of the salience/default mode network, was consistently decreased post-HFS. The global explained variance of microstates A (Auditory network) and E and coverage of microstate A were positively associated with mechanical hypersensitivity. Conversely, the transition probabilities from microstates B (Visual network) to A and the bidirectional transition probabilities between B and C (saliency and default mode networks) were negatively associated with mechanical hypersensitivity. We discuss these findings in the context of the functional significance of EEG microstates. Our results highlight the potential utility of microstate analysis in understanding pain processing and its potential link to changes in the nociceptive system.
Advancements and prospects of transcranial focused ultrasound in pain neuromodulation
Authors: Shi Yu , Wu Wen 
Published: February 2025

Abstract
Transcranial focused ultrasound (tFUS) is an emerging noninvasive neuromodulation technology that has shown great potential in pain modulation. This review systematically elucidates the multilevel biological mechanisms of tFUS neuromodulation, from network-wide effects to cellular and molecular processes, as well as broader systemic influences. Preliminary animal pain model studies have revealed tFUS's ability to improve pain behavioral indicators and modulate neural circuit activity under pathological conditions. A small number of clinical studies also suggest that tFUS may have certain benefits in improving symptom experience and emotional state in chronic pain patients. However, current research generally has limitations such as small sample sizes and short follow-up periods. More high-quality studies are needed to verify the long-term effects and safety of tFUS pain treatment. Overcoming these limitations and advancing large-scale clinical translational research will help fully exploit the application potential of tFUS in precision pain medicine and provide new treatment options for pain relief.
The impact of workplace heat and cold on work time loss
Authors: Ioannou Leonidas G. , Tsoutsoubi Lydia , Mantzios Konstantinos , Gkikas Georgios , Agaliotis Gerasimos , Koutedakis Yiannis , García-León David , Havenith George , Liang Jack , Arkolakis Costas , Glaser Jason , Kenny Glen P. , Mekjavic Igor B. , Nybo Lars , Flouris Andreas D. 
Published: February 2025

Abstract

Objective: We investigated the impact of workplace heat and cold on work time loss. Methods: Field experiments in different industrial sectors were conducted in multiple countries across all seasons between 2016 and 2024. Hundreds of workers were video-recorded and their full shifts (n = 603) were analyzed on a second-by-second basis (n = 16,065,501 sec). Environmental data were recorded using portable weather stations. The Workplace Environmental Labor Loss (WELL) functions were developed to describe work time loss due to workplace temperature. Results: The WELL functions revealed a U-shaped relationship whereby the least work time loss is observed at 18 °C (64 °F), and increases for every degree above or below this optimal temperature. Conclusions: The WELL functions quantify the impact of workplace temperature on work time loss, extending to temperatures previously believed to be unaffected.
The Mystery of Diagnostic Wisdom of Traditional Chinese Medicine Contained in Tianhui Medical Slips
Authors: LI Yitian , YAN Shiyun , CHEN Liyun , LI Guochen 
Published: February 2025

Abstract:
Excavated from the Western Han tomb in Tianhui Town (天回镇), Jinniu District (金牛区), Chengdu, China, Tianhui Medical Slips (《天回医简》) were penned during the Warring States period by the renowned physician Bian Que (扁鹊) and his students. Since their discovery, the medical, historical, and archaeological communities have given them considerable attention. This paper sorts out the diagnostic content of Tianhui Medical Slips from various aspects of inspection, palpation, inquiry, listening and smelling examination and provides a summary and analysis of four features: the concept of the correspondence between heaven and man is the foundation, the idea of the five elements throughout the whole process, extremely focus on pulse diagnosis, emphasize a comprehensive analysis of four examinations. These analyses can investigate the value and significance of Tianhui Medical Slips in developing traditional Chinese medicine (TCM) diagnosis history. In this way, we aim to reproduce the overview and level of TCM diagnostics at that time, clear up some ambiguous understanding of its development history, and provide a reference for further research on the origin and development of TCM.
Delivering an integrated care systems approach for speech and language therapy head and neck cancer services in the UK: service development and redesign in Cheshire and Merseyside
Authors: Sheldrick Heulwen , Kingston Stuart , Crane Julie 
Published: February 2025

Purpose of review
The purpose of this review is to share the implementation of an integrated care systems approach for head and neck cancer speech and language therapy services. Facilitating factors and barriers to change are highlighted and links to relevant literature are indicated. The intention is that this paper will provide a ‘non blueprint’ for others embarking on large scale integrative change.

Recent findings
Integrating health and social care provision across organizations is necessary for improving outcomes for people, reducing health inequalities and improving efficiencies in care. Whilst recognizing this intention, the current structure for providing care in NHS organizations does not foster cross-organizational working.

Summary
Integration enhances patient centred care, however implementation of change across organizations is challenging. Managerial support is pivotal and differences in organizational culture need to be acknowledged, respected and overcome. A clearly defined vision, to which all staff are committed provides an anchor in challenging situations. Transformational change is iterative and cannot always be predetermined. Success is possible; tenacity, flexibility and agility are key.
Sex Differences in Sepsis-Related Acute Respiratory Distress Syndrome and Other Short-Term Outcomes among Critically Ill Patients with Sepsis: A Retrospective Study in China.
Authors: Zhao Hui , Yang Bin , Dai Hong-kai , Li Cheng , Ruan Hang , Li Yong-sheng 
Published: February 2025

Abstract

Background
The evidence of sex disparity in acute respiratory distress syndrome (ARDS) is scarce and varies widely.

Objective
This observational, retrospective study aimed to determine the effect of sex on the sepsis-related ARDS and other short outcomes in critically ill patients with sepsis.

Methods
A total of 2111 adult patients with sepsis who were admitted to three central intensive care units (ICUs) of Wuhan Tongji Hospital between 2012 and 2022 were included in our analysis. Sex was considered as an exposure factor, with sepsis-related ARDS as the primary outcome, and in-hospital mortality, invasive mechanical ventilation(iMV) support, septic shock, and other complications as secondary outcomes.

Results
Among the 2111 enrolled patients, 1287 were males (61%) and 824 were females (39%). The incidence of sepsis-related ARDS was higher in males compared to females (P = 0.001), as well as in-hospital mortality (P = 0.009). Multivariate logistic analysis demonstrated that male sex remained independently associated with an increased risk of sepsis-related ARDS (adjusted odds ratio(aOR) = 1. 493[1.034-2.156], P = 0.032). Propensity score matching analysis also indicated that males had 58% higher odds of developing sepsis-related ARDS (aOR = 1.584 [1.022-2.456], P = 0.040). Regarding secondary outcomes, male sex was identified as a risk factor for in-hospital mortality (aOR = 1.536 [1.087-2.169], P = 0.015) and iMV support (aOR = 1.313 [1.029-1.674], P = 0.028) in the fully adjusted model. Sensitivity analysis that included postmenopausal females and age-matched male counterparts showed that male sex still remained to be a risk factor of developing sepsis-related ARDS (aOR = 1.968 [1.241-3.120], P = 0.004).

Conclusion
Male sex was identified as an independent risk factor for sepsis-related ARDS and in-hospital mortality among critically ill patients with sepsis. Given the retrospective design of this study, the relationship between sex and sepsis-related ARDS requires further validation through large-scale randomized controlled trials in the future.
Towards an Inclusive Conference Experience: Evaluation of the Education & Outreach Symposium at the Microbiology Society Annual Conference 2024
Authors: Lacey Melissa M , Dillon Michael J , Goodman Sean , Easton Victoria , Graham Alison I 
Published: February 2025

The Microbiology Society Education & Outreach Symposium serves as a platform for microbiology educators to share contemporary practices with an international audience. The Symposium is held yearly during the Microbiology Society’s Annual Conference and has become increasingly popular amongst conference attendees. In an effort to create an inclusive and engaging environment, the 2024 Symposium included contributions from participants at all career stages and from diverse global regions through a variety of presentation formats, including invited talks, offered presentations, flash talks, and posters. Cabaret-style seating was used to encourage discussion amongst participants and digital tools were used for anonymous feedback and questions after each talk to ensure all voices had an opportunity to be heard. Here we present an analysis of qualitative and quantitative participant responses addressing two key research questions: 1) Did the Symposium foster an inclusive atmosphere for participants across all career stages? and 2) Was the content engaging and relevant to the audience? A post-Symposium questionnaire revealed strong positive feedback, with all 18 respondents agreeing or strongly agreeing that the 2024 Symposium was both an inclusive environment and covered interesting topics. Thematic content analysis of free-text responses emphasised a high appreciation for the Symposium’s diversity in speakers and topics, an inclusive room layout, and overall welcoming feeling. Feedback from participants, along with the authors’ own reflections, will actively feed into planning for the 2025 Symposium.
Adapting the BOADICEA breast and ovarian cancer risk models for the ethnically diverse UK population
Authors: Ficorella Lorenzo , Yang Xin , Mavaddat Nasim , Carver Tim , Hassan Hend , Dennis Joe , Tyrer Jonathan , Ho Weang-Kee , Teo Soo-Hwang , Hartman Mikael , Li Jingmei , Eriksson Mikael , Czene Kamila , Hall Per , Rahman Tameera , Bacon Andrew , Hardy Steven , Stokes Adam E. , Donoso Francisca Stutzin , Archer Stephanie , Simard Jacques , Pharoah Paul D. P. , Usher-Smith Juliet A. , Tischkowitz Marc , Easton Douglas F. , Antoniou Antonis C. 
Published: February 2025

AbstractBackgroundBOADICEA is a widely used algorithm for predicting breast and ovarian cancer risks, using a combination of genetic and lifestyle/environmental risk factors. However, it has largely been developed using data from individuals of White ethnicity.MethodsWe utilised data from multiple sources to derive estimates for the distributions of risk factors and their effect sizes in major UK ethnic groups (White, Black, South Asian, East Asian, and Mixed). We combined these with ethnicity-specific population cancer incidences to update BOADICEA so that it provides ethnicity-specific risk estimates. We also developed and included a method for deriving adjusted polygenic scores for individuals of mixed genetic ancestry.ResultsThe predicted average absolute risks were smaller in all non-White ethnic groups than in Whites, and the risk distributions were narrower. The proportion of women classified as at moderate or high risk of breast or ovarian cancer, according to national guidelines, was considerably smaller in non-White women.DiscussionThe updated BOADICEA (v7), available in the CanRisk tool (www.canrisk.org), is based on estimates more appropriate for non-White women in the UK. Further validation of the model in prospective studies is required. Considering these findings, risk classification guidelines for non- White women may need to be revised.
Rapid structural network changes in bird communities
Authors: Rigal Stanislas , Devictor Vincent , Dakos Vasilis 
Published: February 2025

AbstractAs biodiversity is declining, the dynamics of species interactions is a growing conservation concern. However, estimating and monitoring species interactions across large spatial and temporal scales remain challenging, and thus changes in species interactions and the subsequent networks of interactions remain relatively unexplored. Here, we assess changes in the network structure of common bird communities from France. We estimate associated species pairs using spatial and temporal information for 109 species monitored across 1,969 sites during 17 years. We validate the ecological significance of associated species pairs by testing the relationship between the propensity to be associated and species functional proximity or shared habitat preference. We reconstruct association networks for these intra-guild bird communities and track temporal changes in network layout in terms of size, density of links, modularity and degree distribution. We show that, beyond species change, birds’ local association networks become smaller with a similar relative number of associations that becomes unevenly distributed. These structural changes vary among types of bird communities and may impact community functioning and how communities can cope with global change.
Rhizoctonia theobromaeassociated with a severe witches’ broom outbreak in cassava of the Brazilian rainforest and evidence of its Southeast Asian origin
Authors: Alves Santos de Oliveira Saulo , Sheat Samar , Margaria Paolo , Lopes Lima Adilson , de Araújo dos Santos Jackson , Rocha Hermínio Souza , Fleck da Silveira Helton , Ramos de Jesus Cristiane , Winter Stephan 
Published: February 2025

AbstractCassava witches’ broom disease (CWBD) has emerged as a significant threat to cassava production in the Oiapoque region of Amapá, Brazil. Diseased plants exhibit stunted growth, vascular necrosis, abnormal shoot proliferation, and distinctive broom-like appearance. This study aimed to characterize the disease and identify its causal agent(s). The assessment by high-throughput sequencing of total nucleic acids (DNA and RNA) from affected cassava tissues revealedRhizoctonia theobromae(syn.Ceratobasidium theobromae) associated with CWBD. PCR-based detection using species-specific primers confirmed the presence ofR. theobromaein 74% of symptomatic samples. Genetic diversity analysis based on the Ca2+/calmodulin-dependent protein kinase gene showed low variability among Brazilian isolates compared with Asian populations, suggesting their recent introduction. This first report ofR. theobromaecausing CWBD in Brazil follows a recent report of the disease from French Guiana and highlights the urgent need for effective measures to prevent the further spread of this emerging pathogen, which poses a deadly threat to cassava cultivation in the rainforest, a significant risk to cassava production in Brazil, and regions with similar eco-climatic conditions.
Towards machine learning fairness in classifying multicategory causes of deaths in colorectal or lung cancer patients
Authors: Feng Catherine H. , Deng Fei , Disis Mary L. , Gao Nan , Zhang Lanjing 
Published: February 2025

AbstractClassification of patient multicategory survival outcomes is important for personalized cancer treatments. Machine Learning (ML) algorithms have increasingly been used to inform healthcare decisions, but these models are vulnerable to biases in data collection and algorithm creation. ML models have previously been shown to exhibit racial bias, but their fairness towards patients from different age and sex groups have yet to be studied. Therefore, we compared the multimetric performances of 5 ML models (random forests, multinomial logistic regression, linear support vector classifier, linear discriminant analysis, and multilayer perceptron) when classifying colorectal cancer patients (n=515) of various age, sex, and racial groups using the TCGA data. All five models exhibited biases for these sociodemographic groups. We then repeated the same process on lung adenocarcinoma (n=589) to validate our findings. Surprisingly, most models tended to perform more poorly overall for the largest sociodemographic groups. Methods to optimize model performance, including testing the model on merged age, sex, or racial groups, and creating a model trained on and used for an individual or merged sociodemographic group, show potential to reduce disparities in model performance for different groups. Notably, these methods may be used to improve ML fairness while avoiding penalizing the model for exhibiting bias and thus sacrificing overall performance.
Proximity of Wildfires to Inpatient Healthcare Facilities in California, 2001-2023
Authors: Dresser Caleb , Bedi Neil Singh , Schroeder Andrew , Sergienko Eric , Balsari Satchit 
Published: February 2025

ABSTRACTObjectiveAssess changes in the proximity of wildfires to inpatient healthcare facilities in California during the period 2001 to 2023.MethodsRetrospective spatial analysis. Distances between each inpatient facility and the nearest wildfire perimeter were computed on an annual basis using data from the California Department of Health Care Access and Information and CAL-FIRE’s Fire and Resource Assessment Program. Temporal changes were analyzed via Kruskal-Wallis and linear models.ResultsThe distance from inpatient healthcare facilities in California to nearby wildfires is decreasing by an average of 628 feet per year, while close approaches are increasing; during 2017-2023, there was 53% increase in the number of inpatient beds within five miles of a wildfire as compared with 2001-2008.ConclusionWildfires are occurring closer to inpatient healthcare facilities in California. An increasing proportion of California’s inpatient bed capacity is exposed to nearby wildfires. Policies to reduce risk posed by wildfires, prepare for evacuations, preserve access to healthcare, and ensure safe location of new facilities are urgently needed to ensure the safety of patients and the wellbeing of populations that depend on inpatient healthcare services.
Taxonomic Shifts Correlate to Serum Cytokines in an Antibiotics Model to Study the Murine Gut-Joint Axis
Authors: Villarreal Cameron X. , Chan Deva D. 
Published: February 2025

ABSTRACTThe gut microbiome interacts with many systems throughout the human body. Microbiome disruption reduces bone tissue mechanics but paradoxically slows osteoarthritis progression. The microbiome also mediates inflammatory and immune responses, including serum cytokines. Towards studying how the gut microbiome interacts with synovial joint health and disease (“gut-joint axis”), we examined how antibiotics-induced changes to microbial taxa abundance associated to serum cytokine levels.Mice (n=8+) were provided ad libitum access to water containing antibiotics (1 g/L neomycin, 1 g/L ampicillin, or 1 g/L ampicillin with 0.5 g/L neomycin) or control water from 5- to 16-weeks old, corresponding in skeletal development to ∼10 to ∼25 years in humans. At humane euthanasia, we collected cecum contents for 16S metagenomics and blood for serum cytokine quantification for comparison to control and among antibiotic groups. We used dimensional reduction techniques, multiomic integration, and correlation to discriminate antibiotic groups and identify specific relationships between high-abundance taxa and serum cytokines.Antibiotic treatment significantly lowered diversity, altered phylum relative abundance, and resulted in significant association with specific taxa. Dimensional reduction techniques and multiomic integration revealed distinct antibiotic-associated clusters based on genera relative abundance and cytokine serum concentration. Cytokines IL-6, MIP-1B, and IL-10 significantly contributed to antibiotic discrimination, significantly different among antibiotic treatments, and had significant correlations with specific taxa.Antibiotic treatment resulted in heterogenous response in gut microbiome and serum cytokines, allowing signficnat microbe-cytokine links to emerge. The relationships identified here will enable further investigation of the gut micrbiome’s role in modifying joint health and disease.