bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluorophore-conjugated 4-1BB antibody enables early detection of T-cell responses in inflammatory arthritis via NIRF imaging
Authors: Duan Shao , Han Chaozhe , Xia Yifei , Jing Chengwei , Dong Bohan , Zhang Xin , Zhang WeiWei , Wang Yu , Zhang Maomao , Li Ping , Chen Weiyu , Xiao Zunyu , Li Chao 
Published: March 2022

Abstract
Purpose

We first developed 4-1BB targeting optical probe---IRDye-680RD-4-1BB mAb and evaluated its capacity for the detection of activated T cells (4-1BB positive) in vivo , as well as the diagnosis of rheumatoid arthritis (RA) in an adjuvant-induced arthritis (AIA) mouse model.

Methods

4-1BB expression pattern was validated and analyzed by flow cytometry and immunofluorescence staining. 4-1BB monoclonal antibody (mAb) was conjugated with IRDye-680RD NHS ester, and characterized via the fluorescent spectrum. Cell binding assay was also performed between activated and naïve murine T cells. Longitudinal NIRF(Near-Infrared fluorescence) imaging of probe was acquired at 24, 48, 72 and 96 hours post probe administration.

Results

4-1BB expression was highly upregulated during RA pathogenesis. Good co-localization was also observed between CD3 and 4-1BB immunofluorescence staining and tSNE analysis, which indicates that 4-1BB was mainly expressed on T cells. Compared to the control group, a significantly higher signal could be detected in the right hind paw from mice with AIA at all time points. Ex vivo biodistribution study was in line with in vivo NIRF imaging, which validated the accuracy of ROI measurements. The sensitivity against 100% specificity observed in receiver operator curves (ROC) analysis could distinguish AIA models from the control group at all time points, indicating the capacity of IRDye680RD-4-1BB mAb in RA diagnosis.

Conclusion

We successfully developed a novel optical imaging probe IRDye-680RD-4-1BB mAb for capturing 4-1BB + activated T cells in vivo , and 4-1BB NIRF imaging is a promising strategy for noninvasively detecting RA pathogenesis.
Resting-state BOLD signal variability is associated with individual differences in metacontrol
Authors: Zhang Chenyan , Beste Christian , Prochazkova Luisa , Wang Kangcheng , Speer Sebastian P.H. , Smidts Ale , Boksem Maarten A.S. , Hommel Bernhard 
Published: March 2022

Abstract
Numerous studies demonstrate that moment-to-moment neural variability is behaviorally relevant and beneficial for tasks and behaviors requiring cognitive flexibility. However, it remains unclear whether the positive effect of neural variability also holds for cognitive persistence. Moreover, different brain variability measures have been used in previous studies, yet comparisons between them are lacking. In the current study, we examined the association between resting-state BOLD signal variability and two metacontrol policies (i.e., persistence vs. flexibility). Brain variability was estimated from resting-state fMRI (rsfMRI) data using three different approaches (i.e., Standard Deviation (SD), Mean Square Successive Difference (MSSD), and sliding time-window correlation (SWC)) and metacontrol biases were assessed by three metacontrol-sensitive tasks. Results showed that brain variability measured by SD and MSSD was highly positively related, while SWC measured variability was not related to the other two measures. Critically, higher variability measured by MSSD in the attention network, parietal and frontal network, frontal and ACC network, parietal and motor network, and higher variability measured by SD in the parietal and motor network, parietal and frontal network were associated with reduced persistence (or greater flexibility) of metacontrol (i.e., larger Stroop effect or worse RAT performance). Our findings show that the beneficial effect of brain signal variability on cognitive control depends on the metacontrol states involved. Moreover, different brain variability measures may capture different aspects of variability and can result in different brain-behavior relationships.
A Health Issue in Urban Politics After the Pandemic COVID-19 Outbreak
Authors: Śleszyński Przemysław , Legutko-Kobus Paulina , Rosenberg Mark , Pantyley Viktoriya , Nowak Maciej J. 
Published: March 2022

Abstract
Background
The aim of this paper is to identify how the literature analyses (identifies, evaluates, forecasts, etc.) the relationship between health issues and urban policy in relation to pandemic COVID-19. Four main levels are identified in these cases: (1) direct demands for change in health care, (2) social issues, (3) spatial organization and (4) redefining the tasks of public authority in the face of the challenges identified.
Methods
The basic working method used in the study assumed a critical analysis of the literature on the subject. The time scope of the search covered articles from January 2020 to the end of August 2021 (thus covering the period of 3 pandemic waves). Combinations of keywords in the titles were used to search for articles.
Results
This process of article qualification ultimately yielded 240 articles for analysis. The health perspective pointed out the need to develop a balance between health care and economic costs and the need to coordinate different specialists/spheres of action.
Conclusions
Such a balance also requires social and spatial analyses, illustrating the diversity of the social situation in individual cities (and more broadly in urbanized areas, including sometimes vast suburbs) and its connection (both in terms of causes and effects) with the intensity of pandemics and other health threats.
Optimal procedure for high-quality chest compression during cardiac arrest resuscitation of a patient in a bathtub: Randomized controlled trial
Authors: Ichiryu Tamotsu , Fujita Koji , Wakita Yoshinori , Shima Yukihiro , Kato Seiya , Nonogi Hiroshi 
Published: March 2022

Abstract
Background
In Japan, the outcome from treatment of bath-related cardiac arrest patients has been poor, because of difficulties with performing cardiopulmonary resuscitation (CPR) of sitting patients in small bathtubs. To clarify the most appropriate CPR in bathtubs, our study was conducted in order to compare the differences in chest compression quality when CPR is performed on sitting and supine patients in a bathtub.
Methods
A total of 52 fire academy students were randomly assigned as ‘rescuers’ to perform chest compression on either a sitting manikin (“Sitting Group”) or a supine manikin (“Supine Group”) in a bathtub. The quality of chest compression performed for 2 minutes by the two different groups was investigated.
Results
The rate of chest compressions with the correct hand position was better in the Supine Group (96.1%) than in the Sitting Group (94.6%; p < 0.01). The rate of total chest compressions with correct recoil was greater in the Sitting Group than in the Supine Group (60.5% versus 13.5%, p < 0.001). In the Supine Group, the average depth of chest compression (48.4 mm) was better than in the Sitting Group (40.8 mm; p < 0.001). Although in both groups, the depth of chest compressions gradually attenuated significantly with time, the optimal compression depth for survival was nearly maintained. In the Supine Group, the number of participants with appropriate chest compression depth was kept during 2-minute CPR.
Conclusion
The rescuer’s chest compression quality during CPR in the bathtub was better with supine patients than with sitting patients due to the difference in accumulated fatigue of the rescuer.
Triptolide impairs LUAD cells through the JAK-STAT signaling pathway by activating autophagy
Authors: tang ning , Tian Zhongxian , Zhang Wenhao , Luo Junwen , Du Feng , Zhang Wei , Xiao Zhaohua , Li Peiwei , Zhao Xiaogang 
Published: March 2022

Abstract
Background

Triptolide, an extract from the Chinese herb Tripterygium wilfordii , has shown anticancer activity in vitro and in vivo. In our present study, we aimed to investigate its antitumor effects by examining proliferation, migration, and invasion and the potential mechanism of autophagic induction in lung cancer cells.

Methods

An MTT assay was used to measure triptolide-mediated inhibition of Lung adenocarcinoma (LUAD)cell (A549 and NCI-H1299) viability. Colony formation, EdU, migration and invasion assays were used to examine the effects of triptolide on the proliferation, migration and invasion of lung cancer cells. Western blot analysis was used to examine the expression of various related proteins. Immunofluorescence assays were used to examine the protein expression of LC3B. Reverse transcription-quantitative polymerase chain reaction (RT–qPCR) was used to examine the mRNA levels of MYC and LIF. Bioinformatics analysis (KEGG, etc.) was used to reveal the pathways that are regulated by triptolide.

Results

Triptolide inhibits proliferation, migration and invasion and induces autophagy in A549 and NCI-H1299 LUAD cells. Inhibition of autophagy can reverse its inhibitory effects. Moreover, triptolide impaired lung cancer cell proliferation, migration and invasion through the JAK-STAT signaling pathway.

Conclusion

Triptolide attenuated proliferation, migration and invasion in LUAD cells through autophagy initiation resulted in the JAK-STAT signaling pathway. Triptolide has the potential to be an alternative therapeutic agent for lung cancer.
Facile in-situ construction of granular–polyhedral Ag2O–Ag2CO3/lamellar Bi2O2CO3–Bi2MoO6 spherical heterojunction with enhanced photocatalytic activity towards pollutants
Authors: Zhang Yu , Ma Fengyan , Ling Meihua , Han Yanan , Lv Dandan , Wang Zhengjun , Zhao Huaping , Zhang Wenzhi , Li Li 
Published: March 2022

Abstract
Using Bi2MoO6 hollow spheres as precursors, NaOH as etchant and atmospheric CO2 as carbon source, a granular–polyhedral Ag2O–Ag2CO3/lamellar Bi2O2CO3–Bi2MoO6 spherical heterojunction material with full–spectrum photocatalytic properties was gained through a one step in-situ precipitation approach. Granular Ag2O, polyhedral Ag2CO3 and lamellar Bi2O2CO3 were deposited in-situ on the interior and exterior surfaces of Bi2MoO6 hollow spheres to form nanospheres with a diameter of about 2.8 µm. Using methylene blue (MB) as a model molecule, the effect of NaOH concentration and silver oxide loading on the catalyst activity was investigated to screen out the best catalyst. The results showed that the degradation rate of Ag2O–Ag2CO3/Bi2O2CO3–Bi2MoO6-1/2-0.1 M was 3.45 and 2.71 times greater than those of Ag2O–Ag2CO3 and Bi2O2CO3–Bi2MoO6-0.1 M, respectively. Meanwhile, the visible light photocatalytic performance of Ag2O–Ag2CO3/Bi2O2CO3–Bi2MoO6 toward MB and antibiotics (tetracycline hydrochloride (TC), chlorotetracycline hydrochloride (CTC)) were also examined. Results confirm that the heterogeneous materials displayed the boosted photocatalytic activity for MB, TC and CTC. The boosted activity of the composite Ag2O–Ag2CO3/Bi2O2CO3–Bi2MoO6 is attributed to improved the utilization of light, increased surface active sites, and formation effective heterojunction between Ag2O–Ag2CO3 and Bi2O2CO3–Bi2MoO6. Capture experiments have shown the major active species in the photocatalytic degradation system, and a plausible photocatalytic mechanism has been postulated in conjunction with photoelectrochemical experiments.
Heat-Transfer Performance of Twisted Tubes for Highly Viscous Food Waste Slurry from Biogas Plants
Authors: Chen Jingjing , Risberg Mikael , Westerlund Lars , Jansson Urban , Wang Changsong , Lu Xiaohua , Ji Xiaoyan 
Published: March 2022

Abstract
Background
The use of food waste as feedstock shows high production of biogas via anaerobic digestion but requires efficient heat transfer in food waste slurry at heating and cooling processes. The lack of rheological properties hampered the research on the heat-transfer process for food waste slurry. Referentially, the twisted hexagonal and elliptical rubes have been proved as the optimal enhanced geometry for heat transfer of medium viscous slurries with non-Newtonian behavior and Newtonian fluids, respectively. It remains unknown whether improvements can be achieved by using twisted geometries in combination with food waste slurry in processes including heating and cooling.
Results
Food waste slurry was observed to exhibit highly viscous, significant temperature-dependence, and strongly shear-thinning rheological characteristics. Experiments confirmed the heat-transfer enhancement of twisted hexagonal tubes for food waste slurry and validated the computational fluid dynamics-based simulations with an average deviation of 14.2%. Twisted hexagonal tubes were observed to be more effective at low-temperature differences and possess an enhancement factor of up to 2.75; while twisted elliptical tubes only exhibited limited heat-transfer enhancement at high Reynolds numbers. The heat-transfer enhancement achieved by twisted hexagonal tubes was attributed to the low dynamic viscosity in the boundary layer induced by the strong and continuous shear effect near the walls of the tube.
Conclusions
This study determined the rheological properties of food waste slurry, confirmed the heat-transfer enhancement of the twisted hexagonal tubes experimentally and numerically, and revealed the mechanism of heat-transfer enhancement based on shear rate distributions.
Malaria-VisAnalytics: a tool for visual exploratory analysis of Brazilian public malaria data
Authors: Sironi Alberto Pietro , Bertoldo Juracy , Sampaio Vanderson , Coimbra Danilo , Rasella Davide , Barreto Marcos Ennes 
Published: March 2022

Abstract
Background: Data integration and visualization techniques have been widely used in scientific research to allow the exploitation of large volumes of data and support highly complex or long-lasting research questions. Integration allows data from different sources to be aggregated into a single database comprising variables of interest for different types of studies. Visualization allows large and complex data sets to be manipulated and interpreted in a more intuitive way.Methods: Integration and visualization techniques were applied in a malaria surveillance ecosystem to build an integrated database comprising notifications, deaths, vector control and climate data. This database is accessed through Malaria-VisAnalytics, a visual mining platform for descriptive and predictive analysis supporting decision and policy-making by governmental and health agents.Results: Experimental and validation results have proved that the visual exploration and interaction mechanisms allow effective surveillance for rapid action in suspected outbreaks, as well as support a set of different research questions over integrated malaria electronic health records.Conclusion: The integrated database and the visual mining platform (Malaria-VisAnalytics) allow different types of users to explore malaria-related data in a user-friendly interface. Summary data and key insights can be obtained through different techniques and dimensions. The case study on Manaus can serve as a reference for future replication in other municipalities. Finally, both the database and the visual mining platform can be extended with new data sources and functionalities to accommodate more complex scenarios (such as, real-time data capture and analysis).
The prognostic value of admission lymphocyte-to-monocyte ratio in acute myocardial infarction patients
Authors: Zhao Yuanyuan , Hao Chunshu , Bo Xiangwei , Lu Zhengri , Qian Hao , Chen Lijuan 
Published: March 2022

Abstract
Background: Inflammation plays a critical role in acute myocardial infarction (AMI). Recent studies have shown the value of hematologic indicators in MI risk stratification and prognostic assessment. However, the association between lymphocyte-to-monocyte ratio (LMR) and the long-term mortality of critically ill MI patients remains unclear.Methods: Clinical data were extracted from the Medical Information Mart for Intensive Care III (MIMIC-III) database. Patients diagnosed with AMI on admission in the intensive care units (ICUs) were include. The optimal cutoff value of LMR was determined by X-tile software. The Cox proportional hazard model was applied for the identification of independent prognostic factors of 1-year mortality and survival curves were estimated using the Kaplan-Meier method. In order to reduce selection bias, a 1:1 propensity score matching (PSM) method was performed.Results: A total of 1517 patients were included. The optimal cutoff value of the LMR for 1-year mortality was 3.00 calculated by X-tile software. 543 pairs of patients were score-matched eventually. The Cox proportional hazard model showed that patients with an LMR < 3.00 had a significantly higher 1-year mortality than patients with an LMR≥3.00 in the multivariate analysis (HR=1.369, 95%CI: 1.110-1.687, P=0.003) and the PSM subset (HR=1.299, 95%CI: 1.032-1.634, P=0.026). The survival curves showed that patients with an LMR<3.00 had a significant lower 1-year survival rate in the entire cohort (63.83 vs.81.03%, Log rank P<0.001) and the PSM subset (68.13 vs.74.22%, Log rank P=0.041).Conclusion: In this retrospective cohort analysis, we demonstrated that a low admission LMR (<3.00) was associated with a higher risk of 1-year mortality in critical ill patients with AMI.
“My Mom took My Phone and Locked It in the Wardrobe”: Parental Mediation in Teen-Parent Relationship in Technology Usage from Teens Perspective in Bangladesh
Authors: Rony Rahat Jahangir , Ahmed Nova 
Published: March 2022

Abstract
The teen-parent relationship is studied from the perspective of teens relating to the usage of technology in the context of urban Bangladesh. We studied n=28 teens of different socioeconomic statuses and school systems qualitatively. The study uncovers the current state of teen-parent relationships where parental mediation on teens' technology usage impacts the relationship. Parents of middle and lower-income families want to control the technology usage of female teens for cyber abuse-related concerns. This parental restrictive mediation negatively impacts teen-parent relationships. Also, teens from higher-income families hide their online activities from their parents for fear of monitoring and often exclude parents in their cyberspace. As a result, there create strong barriers in online relationships with parents that refer to distant relationships between them. However, a good understanding regarding technology usage between teens and parents impacts the relationship positively. Based on our findings, we have presented design implications that can ensure a safe online platform for teens, co-sharing transparent technology usage space, and community level discussion platform, for both teens and parents to promote a good relationship between teens and parents.
Atherogenic index of plasma is a novel and strong predictor of non-alcoholic fatty liver disease in non-obese participants: a retrospective cohort research of China
Authors: Li Jingnan , Li Kemin 
Published: March 2022

Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) in the non-obese population accounts for a large proportion of NAFLD. The association between the atherogenic index of plasma (AIP) with the risk of NAFLD was limited, especially among non-obese participants.Methods: We performed a post-hoc analysis of data obtained from the Dryad data repository and explored the predictive value of AIP on the risk of NAFLD among non-obese participants. Results: 16173 participants with AIP were included in this study, and 2322(14.4%) non-obese participants developed into individuals with NAFLD with the 5-year follow-up examination. The difference between AIP quartiles in the cumulative estimation of new-onset NAFLD was significant. And with increased AIP, the cumulative primary outcomes gradually increased. Participants in higher AIP quartiles had a significantly increased risk of NAFLD. In the fully adjusted Model 3, HRs of the primary outcome for subjects in Q2, Q3, and Q4 of AIP were 1.56 (1.29, 1.89), 2.12 (1.78, 2.53), and 2.78 (2.35, 3.92) respectively. Meanwhile, the trend test for the association between AIP quartiles and the primary outcome presented that AIP quartile was positively and strongly associated with the primary outcome (adjusted HR (95%CI) in Model 3: 1.37 (1.31, 1.44), P<0.001). In the subgroup analysis, we revealed a significant interaction between systolic blood pressure categories (<120mmHg vs. >=120mmHg; P for interaction =0.011) and NAFLD.Conclusion: This study found AIP was a strong independent risk factor for new-onset NAFLD among non-obese individuals and screening for AIP in this population can be used to prevent future NAFLD.
Preparation of Polyimide/Polyethersulfone high temperature resistant nano-fibers for removal of particulate matter
Authors: Chen Wei-Ting , Chen Hua-Wei , Lai Yi-Hung 
Published: March 2022

Abstract
Taguchi method was used to determine factors influence, while four factors included ratio of PI and PES, flow rate, voltage, and spinning time, for testing filter efficiency of electrospinning fiber. Spinning time and flow rate were arranged as the top two influenced factors via Taguchi method in this study. Considering test of spinning time, spinning time of 20 min was defined as the best condition to generate the fibrous membrane with filter efficiency and quality of 99.54% and 5.56. Concerning test of flow rate, flow rate of 0.15 ml/hr was the best condition to form the fibrous membrane with filter efficiency and quality of 93.84% and 0.88. This study showed the best conditions of filter efficiency and quality that valued as 93.82% and 2.90 while the most optimal conditions presented ratio of PI and PES (50:50), flow rate (0.15 ml/hr), voltage (22.5 kV), and spinning time (20 mins).Thermogravimetry and differential scanning calorimetry were used to conduct thermal analysis of nano-fiber membrane, and results depicted decomposed temperature of PI and PES were above 500 and 400 ℃. Furthermore, temperature of hot gas filiation usually occurred at the temperature of above 260 ℃, such as 200–350 ℃ for waste incineration, 150–300 ℃ for concrete producing, 130–150 ℃ for thermal power plant operation, and 171–210 ℃ for crematorium operation, so the PI/PES acquired potential advantage on application of hot gas filiation because PI/PES membrane required not only high temperature resistance but also high filter efficiency and quality.
Evaluation of nonlinear dynamic patterns of extreme precipitation and temperatures in central England during 1931–2019
Authors: Rahmani Farhang , Fattahi Mohammad Hadi 
Published: March 2022

Abstract
Since climate change has altered extreme precipitation and temperature patterns, further study of these patterns is essential. The examination of precipitation and temperature patterns is of great significance to water engineers, water resources management, and hydrological studies. Accordingly, this study explored the nonlinear dynamic patterns and their sources governing extreme precipitation and temperatures using multifractal, shuffling, surrogating techniques, and extreme climate indices. The temperature and precipitation data regarding central England (1931–2019) were collected and used for analysis. The results of extreme climate indices demonstrated climate change in the study area. Besides, the multifractal analysis indicated that all indices’ time series were characterized by multifractality. Despite the fact that multifractality of the maximum 1-day precipitation, minimum of maximum temperature, and maximum of maximum temperature was predominantly produced by correlation properties (long-range correlations between small and large local fluctuations), the multifractal characteristics of the warm nights were due to a probability density function (PDF) predominance. Moreover, multifractal properties of the diurnal temperature range, maximum 5-day precipitation, maximum of minimum temperature, minimum of minimum temperature, cool nights, and cool and warm days were produced by the identical extent of correlation properties and the PDF.