bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep problems in autism: Sex differences in the school‐age population
Authors: Estes Annette , Munson Jeffrey , St. John Tanya , Finlayson Robin , Pandey Juhi , Gottlieb Bridget , Herrington John , Schultz Robert T. 
Published: November 2022

AbstractClinically significant sleep problems affect up to 86% of the autistic population in school‐age. Sleep problems can have negative impacts on child cognition, behavior, and health. However, sex differences in the prevalence and types of sleep problems are not well understood in autism. To evaluate sex differences in sleep problems in the school‐age autistic population, we obtained parent‐report of sleep problems on the Children's Sleep Habits Questionnaire and conducted direct assessments to establish diagnosis and intellectual ability in 6–12‐year‐old children (autismn = 250; typical development [TD]n = 114). Almost 85% of autistic females demonstrated sleep problems compared to 65.8% of autistic males, 44.8% of TD females, and 42.4% of TD males; a statistically significant increase for autistic females. Autistic females demonstrated increased bedtime resistance, sleep anxiety, and sleepiness, and decreased sleep duration, but did not differ in sleep onset delay, night wakings, parasomnias, or disordered breathing compared with autistic males. Intellectual ability was not related to increased sleep problems. Higher anxiety scores were associated with more sleep problems for males but not females. In one of the first studies to evaluate sex differences in sleep in the school‐age, autistic population, autistic females demonstrated increased sleep problems compared to autistic males, TD females, and TD males. Current autism assessment and intervention practices may benefit from increased attention to sleep problems in autistic school‐age females and to anxiety in autistic males to enhance well‐being and behavioral and health outcomes.
Prepregnancy exposure to dietary arsenic and congenital heart defects
Authors: Suhl Jonathan , Conway Kristin M. , Rhoads Anthony , Langlois Peter H. , Feldkamp Marcia L. , Michalski Adrian M. , Oleson Jacob , Sidhu Alpa , Scholz Thomas D. , Kancherla Vijaya , Obrycki John , Mazumdar Maitreyi , Romitti Paul A. ,   the National Birth Defects Prevention Study
Published: November 2022

AbstractIntroductionArsenic crosses the placenta and accumulates in fetal tissues. In the United States, diet is the predominant route of arsenic exposure, but epidemiologic data are sparse regarding this exposure and development of birth defects. Using data from a large case‐control study, we explored associations between maternal dietary arsenic exposure and congenital heart defects (CHDs), the most prevalent birth defects.MethodsWe used maternal self‐reported dietary assessments and arsenic concentration estimates in food items to estimate average daily exposure to dietary arsenic during the year before pregnancy for mothers of 10,446 unaffected control children and 6,483 case children diagnosed with CHDs. Using tertiles of dietary exposure to total arsenic (all species) and inorganic arsenic, we applied logistic regression analysis to estimate associations for middle and high tertiles, compared with the low tertile.ResultsPositive associations (odds ratio [OR] ≥ 1.2) for total arsenic were observed in both tertiles for perimembranous ventricular septal defect (VSD) and high tertile only for double outlet right ventricle‐transposition of the great arteries (DORV‐TGA), partial anomalous pulmonary venous return (PAPVR), and tricuspid atresia. Positive associations were also observed in both tertiles (tricuspid atresia) and high tertile only (DORV‐TGA, conoventricular VSD, PAPVR, and pulmonary atresia) for inorganic arsenic. Most remaining associations were near or below unity.DiscussionExploration of maternal dietary exposure to total and inorganic arsenic and CHDs produced few positive associations but was limited by available food item concentrations. Future research requires expanded collection of dietary data, improved estimates of concentrations, and consideration of nondietary sources of arsenic exposure.
Bilateral medial sacrospinous ligament suture for apical suspension through natural spaces: A single‐center study with low perioperative complications
Authors: OuYang Yinluan , Xu Wei , Li Fan , Chen Yiwen , Yuan Tao , Wu Xiaomei , Zhao Xiaofeng 
Published: November 2022

AbstractSacrospinous ligament fixation (SSLF) is one of the most used native tissue approaches for apical suspension with a high rate of perioperative complications. This study aimed to review cases undergoing a modified SSLF and assess its perioperative adverse events. It was a retrospective study of 168 consecutive patients undergoing modified transvaginal SSLF at a single tertiary center from 2017 to 2021. The sutures were placed on the sacrospinous ligament (SSL) approaching the sacrum through natural spaces under direct vision. Moreover, it was performed bilaterally. Patient demographics and perioperative complications were reviewed. The median age was 65 years, and 85.7% (144/168) had stage III–IV prolapse. Among the 168 patients undergoing this modified SSLF, 161 were for uterovaginal prolapse, and seven were for posthysterectomy vaginal vault prolapse. 83.9% (135/161) patients were concomitant with hysterectomy, and 70.2% (118/168) were with anteroposterior colporrhaphy. The median operation time was 82 min (interquartile range [IQR], 61–100 min), and the median intraoperative blood loss was 50 ml (IQR, 30–50 ml). Two cases had pelvic hematoma, and both were cured after expectant treatment. No patient required a homologous blood transfusion, and none complained about buttock or lower limb pain 2 weeks postoperatively. Nor did injury of the ureters, bladder, or rectum occur intraoperatively. This modified transvaginal SSLF procedure was safe and had no severe perioperative complications.
Application of NGS molecular classification in the diagnosis of endometrial carcinoma: A supplement to traditional pathological diagnosis
Authors: Rao Qunxian , Liao Jianwei , Li Yangyang , Zhang Xin , Xu Guocai , Zhu Changbin , Tian Shengya , Chen Qiuhong , Zhou Hui , Zhang Bingzhong 
Published: November 2022

AbstractObjectiveThis study aims to demonstrate the advantages of NGS molecular classification in EC diagnosis and to assess whether molecular classification could be performed on curettage specimens and its concordance with subsequent hysterectomy specimens.Methods80 patients with hysterectomy specimens and 35/80 patients with paired curettage specimens were stratified as POLE mut, MSI‐H, TP53 wt, or TP53 abn group by NGS panel. Histotype, tumor grade, IHC results, and other pathological details were taken from original pathological reports.ResultsThe correlation analysis of 80 patients with hysterectomy specimens between NGS molecular classification and clinicopathological characters displayed that the POLE mut group was associated with EEC (87.5%) and TP53 abn subtype was correlated to a later stage (Stage II–IV, 47.6%), G3 (76.2%), serous histology (61.9%) and myometrial invasion ≥50% (47.6%). A favorable concordance (31/32, 96.9%) was shown in MSI analysis and MMR IHC results, and the agreement rate of p53 IHC and TP53 mutation was 81.5% (53/65). Compared with the p53 IHC abnormal group, the TP53 mutation group had a higher correlation with high‐risk factors. A high level of concordance (31/35, 88.0%) of NGS molecular classification was achieved between curettage specimens and hysterectomy specimens while grade and histotype (including unclassified group) from curettage specimens and hysterectomy specimens showed only moderate levels of agreement, 54.3% (19/35) and 68.6% (24/35), respectively.ConclusionNGS molecular classification achieved on curettage samples showed high concordance with the final hysterectomy specimens, demonstrating superior to the conventional pathological assessment of grade and histotype and potential utilization in clinical practice.
Regional anesthesia as a safe option in patient with limb girdle muscular dystrophy undergoing total abdominal hysterectomy: A case report and case review
Authors: Devkota Sagar , Shrestha Sangeeta , Gurung Tara , Shrestha Saurav 
Published: November 2022

AbstractRegional anesthesia can be a very safe option in patients with limb girdle muscular dystrophy undergoing lower abdominal surgeries as general anesthesia and volatile anesthetic agents are associated with increased risk of malignant hyperthermia and rhabdomyolysis.
Revised Bell Particle‐Particle Drag Model of Bicomponent Cohesive Particles in a Fluidized Bed
Authors: Chen Juhui , Zheng Zhijie , Li Dan , Zhang Zongyun , Zhao Chenxi , Liu Xiaogang , Sun Yongguo , Han Changliang , Yu Guangbin 
Published: November 2022

AbstractIn the framework of the two‐fluid model, the kinetic theory of cohesive particle flow is applied to bicomponent cohesive particle flow. Based on the Bell particle‐particle drag model, the revised Bell particle‐particle drag model is presented for the bicomponent cohesive particle flow, considering the impact of the particle surface energy on the collision process. The flow characteristics of a mixture of Geldart group A particles and ultrafine particles were studied. The results show that the simulated elutriation rate is in good agreement with the experimental data, which verifies the effectiveness of the cohesive particles drag model.
Tribological Performances of Diamond‐Like Carbon Coatings for Hydraulic Applications
Authors: Kapsiz Murat , Geffroy Stefan , Holzer Achill , Schmitz Katharina 
Published: November 2022

AbstractThe tribological performance of contacts within hydraulic pumps over a wide range of conditions is essential for the sustainability of mobile hydraulic systems. To reduce the energy consumption of hydraulic systems, mechanical losses and wear rates need to be reduced. Additionally, materials containing lead must also be replaced due to their environmental impact. In this study, the performance of different lead‐free combinations of hydrogenated diamond‐like carbon (hydr. DLC) coatings were investigated. For this purpose, the tribological behavior of hydr. DLC (Balinit DLC), ceramic‐doped hydr. DLC (Balinit C), and ceramic bond‐coated hydr. DLC (Balinit DLC Star) coatings on a nitride steel substrate were compared in tribometer tests.
NMR Investigation of Protein‐Carbohydrate Interactions: The Recognition of Glycans by Galectins Engineered with Fluorotryptophan Residues
Authors: Lete Marta G. , Franconetti Antonio , Bertuzzi Sara , Delgado Sandra , Azkargorta Mikel , Elortza Félix , Millet Oscar , Jiménez‐Osés Gonzalo , Arda Ana , Jiménez‐Barbero Jesús 
Published: November 2022

AbstractFluorine (19F) incorporation into glycan‐binding proteins (lectins) has been achieved and exploited to monitor the binding to carbohydrate ligands by nuclear magnetic resonance (NMR) spectroscopy. Galectins are a family of lectins that bind carbohydrates, generally with weak affinities, through a combination of intermolecular interactions including a key CH‐π stacking involving a conserved tryptophan residue. Herein, Galectin‐3 (Gal3) and Galectin‐8 (Gal8) with one and two carbohydrate recognition domains (CRDs), respectively, were selected. Gal3 contains one Trp, whereas Gal8 contains three, one at each binding site and a third one not involved in sugar binding; these were substituted by the corresponding F‐Trp analogues. The presence of fluorine did not significantly modify the affinity for glycan binding, which was in slow exchange on the 19F NMR chemical‐shift timescale, even for weak ligands, and allowed binding events taking place at two different binding sites within the same lectin to be individualized.
Durch Wartung zur Anlage von morgen
Authors: Schulze Tania 
Published: November 2022

AbstractInstandhaltung ist ein wichtiger Teil der gesamten Anlagenstrategie. Wie kann Instandhaltung digitalisiert werden, welche Hürden müssen gemeistert werden und warum ist die Automation so wichtig für die Anlage der Zukunft? Mobile, digitale Werkzeuge in der Instandhaltung sind ein erster Schritt in die Digitalisierung von Anlagen.
Intelligente Rohrleitungssysteme in der Prozessindustrie
Authors: Walter Antoine 
Published: November 2022

AbstractIn der chemischen Prozessindustrie müssen Rohrleitungssysteme sehr hohe und spezifische Anforderungen erfüllen. Sie bilden ein Netzwerk, in dem zahlreiche Sensoren die Produktqualität sicherstellen können. Komplettlösungen aus Rohren, Ventilen und dem passenden Regelsystem unterstützen einen Anbieter für mobile Wasseraufbereitungsanlagen – auch weil Kunststoffrohre die Mobilität der Anlagen erleichtern.
Insight into the Interaction of Furfural with Metallic Surfaces in the Electrochemical Hydrogenation Process
Authors: Lenk Thorben , Rabet Sahar , Sprick Miriam , Raabe Gabriele , Schröder Uwe 
Published: November 2022

AbstractElectrocatalytic hydrogenation of furfural on metal surfaces has become an important research subject due to the potential of the reaction product 2‐methylfuran as a renewable energy resource. Identifying effective determinants in this reaction process requires a thorough investigation of the complex electrode‐electrolyte interactions, which considers a variety of the influential components. In this work, in operando electrochemical Raman Spectroscopy and Molecular Dynamics simulations were utilized to investigate different characteristics of the interface layer in the electrocatalytic hydrogenation of furfural. Hereby, the influence of applied potentials, electrode material, and electrolyte composition were investigated in detail. The studied parameters give an insight into furfural's binding situation, molecular orientation, and reaction mechanism.
Polyaniline‐ZnO−NiO Nanocomposite Based Non‐enzymatic Electrochemical Sensor for Malathion Detection
Authors: Chufamo Jikamo Samuel , Haile Habtemariam Tesfaye , Heliso Dolla Tarekegn 
Published: November 2022

AbstractAn electrochemical sensor based on polyaniline‐ZnO−NiO (PANI‐ZnO−NiO) nanocomposite was developed for the non‐enzymatic detection of malathion. The structure, surface morphology, and optical properties of the as‐prepared nanocomposite were studied by XRD, FTIR, SEM, and UV‐Vis spectroscopy. The electrochemical behavior of the nanocomposite based sensor was first evaluated through cyclic voltammetry (CV). Under optimum conditions, differential pulse voltammetry (DPV) was further utilized for malathion detection, which proved the PANI‐ZnO−NiO/GCE electrode as an effective electrochemical sensor. The developed electrochemical sensor showed a low detection limit of 1.0×10−8 M with a wider linear range of 10 to 70 nM for malathion.
Parallel imports under a manufacturer rebate and a price freeze: Evidence from Germany
Authors: Birg Laura 
Published: November 2022

AbstractI study the effect of a change in the mandatory manufacturer rebate and a price freeze on wholesale prices for pharmaceuticals on competition by parallel imports. First, I analyze the effect of a manufacturer rebate on competition by parallel imports in a two‐country model. Second, I exploit a policy reform in Germany in 2010 that increased the manufacturer rebate by 10 percentage points. Using a data set with prescription drugs with competition from parallel imports, I estimate the effect of the change in the manufacturer rebate on competition by parallel imports. The model predicts that an increase in the manufacturer rebate increases the market share of parallel imports. The rebate decreases the manufacturer's revenues from domestic distribution. In response, the manufacturer lowers the wholesale price for a foreign distributor, resulting in a competitive advantage for and an increase in the market share of parallel imports. The estimation shows that the increase in the manufacturer rebate by 10 percentage points has increased the market share of parallel imports by approximately 18%–35% and has increased the number of importers by up to 17%.
The efficacy of pharmacological interventions to improve cognitive and behavior symptoms in people with dementia: A systematic review and meta‐analysis
Authors: Takramah Wisdom K. , Asem Livingstone 
Published: November 2022

AbstractBackground and AimsDementia is becoming a major global public health menace in the aging population affecting 47 million people globally. Dementia has no cure and effective interventions. Treatment of dementia is a big problem. The most common symptomatic medications for cognition, behavior, and global functioning among patients with dementia currently are cholinesterase inhibitors and memantine. However, Information on the effectiveness of cholinesterase inhibitors for dementia is conflicting and controversial. Thus, this makes it difficult for decision‐makers, healthcare providers, patients, and caregivers to decide on the most effective intervention. The current meta‐analysis sought to investigate the efficacy of pharmacologic interventions to improve cognitive and behavioral symptoms in people with living dementia.MethodsThis current systematic review and meta‐analysis used the preferred reporting items for systematic reviews and meta‐analyses to ensure accuracy and comprehensiveness. The Cochrane MEDLINE, Database of Systematic Reviews, and other databases were thoroughly searched for relevant studies. We selected Studies such as randomized controlled trials published in English with a sample size of at least 20 subjects. We selected and applied the random‐effects meta‐analysis as the most preferred model because of the heterogeneity across studies. The computation of the weighted effect size was based on the result from the test of heterogeneity.ResultsTwenty‐two studies were finally used in the meta‐analysis. The study subjects who received donepezil 5 mg/day, donepezil 10 mg/day, and galantamine 24 mg/day had improved cognition symptoms (ADAS‐cog) score of −1.46 (95% CI = −2.24, −0.68, z = 3.67, p < 0.001), −2.31 (95% CI = −3.30, −1.31, z = 5.45, p < 0.001) and −3.04 (95% CI = −4.16, −1.92, z = 5.31, p < 0.001) respectively.ConclusionThe current meta‐analysis suggests significant benefits of cholinesterase inhibitors such as donepezil (5 and 10 mg/day) and galantamine on cognitive symptoms.
Thermal‐induced Buckling analysis of microbeams with intermediate support under thermal load based on modified couple stress theory
Authors: Wang Fengjuan 
Published: November 2022

AbstractThis study investigates the buckling of microbeams with variable cross‐sections and middle supports in a thermal environment. Based on classical theories and modified couple stress, the size‐dependent behavior of the microbeam is modeled, and the intermediate support is simulated elastically. A temperature‐dependent relationship will also be assumed for the material properties of the microbeam. The governing equations will be derived using Hamilton's principle based on the modified Couple stress theory and the nonlinear thermal field. Using an analytical approach, buckling loads and deformation of microbeams will be determined. The accuracy of the answers will be investigated to demonstrate the effectiveness of the method used and the correctness of the results obtained. A comparison will be made between the obtained results and the results available in the scientific literature to prove the accuracy of the formulation and the method used. A parametric study will then be conducted to determine the effect of boundary conditions, the flexibility of the middle support, temperature distribution, and geometric characteristics on the buckling loads of microbeams.
Research progress on the effects and mechanisms of anesthetics on neural stem cells
Authors: Zhang Ji , Chang Quan‐Yuan , Rizzello Loris , Wu You 
Published: November 2022

AbstractExposure to anesthetic drugs has been proven to seriously affect developing animals in terms of neural stem cells' (NSCs') proliferation, differentiation, and apoptosis. This can severely hamper the development of physiological learning and memory skills. Studies on the effects of anesthetics on NSCs' proliferation and differentiation are thus reviewed here, with the aim to highlight which specific drug mechanisms are the least harmful to NSCs. PubMed has been used as the preferential searching database of relevant literature to identify studies on the effects and mechanisms of NSCs' proliferation and differentiation. It was concluded that propofol and sevoflurane may be the safest options for NSCs during pregnancy and in pediatric clinical procedures, while dexmedetomidine has been found to reduce opioid‐related damage in NSCs. It was also found that the growth environment may impact neurodevelopment even more than narcotic drugs. Nonetheless, the current scientific literature available further highlights how more extensive clinical trials are absolutely required for corroborating the conclusion drawn here.
A decreased number of circulating regulatory T cells is associated with adverse pregnancy outcomes in patients with systemic lupus erythematosus
Authors: Li He‐Tong , Zhang Sheng‐Xiao , Zhang Jia‐Qi , Cheng Ting , Liu Yan , Liu Hong‐Qi , Hao Min , Chen Jun‐Wei 
Published: November 2022

AbstractObjectiveAs an autoimmune disease affecting women of reproductive age, systemic lupus erythematosus (SLE) is linked to adverse fetal and maternal outcomes. However, the status of peripheral lymphocytes in SLE patients with different pregnancy outcomes is unclear. This retrospective cross‐sectional study explored the relationship between lymphocyte subpopulations and pregnancy outcomes in married SLE female patients.MethodsThe absolute numbers of peripheral T, helper T (Th)1, Th2, Th17, regulatory T (Treg), B, and natural killer (NK) cell subpopulations from 585 female SLE patients and 91 female healthy controls (HCs) were assessed. We compared the lymphocyte subpopulations in SLE patients with HCs and analyzed the absolute number and ratio of Treg cells according to pregnancy outcome in SLE patients.ResultsSLE patients had decreased numbers of T, B, NK, Th1, Th2, Th17, and Treg cells and an imbalance in pro‐ and anti‐inflammatory cells (p < .05), as well as adverse pregnancy outcomes. In abortion patients, the number of Treg cells (p = .008) decreased, leading to an imbalance in effector T and Treg cells. The ratio of Treg cells was higher in SLE patients with nulliparity than in those with one or two parities.ConclusionsThe absolute numbers of lymphocyte subpopulations in SLE patients decreased, which was associated with abortion and parity (p < .05). These results suggest that a loss of immune tolerance mediated by Tregs triggers pregnancy loss.
Emergence of SARS‐CoV‐2 Omicron variant and strategies for tackling the infection
Authors: Wu Yan , Long Yiyin , Wang Feng , Liu Wei , Wang Yuliang 
Published: November 2022

AbstractIntroductionNowadays, emerging SARS‐CoV‐2 Omicron, the novel highly mutated VOC, has quickly spread as the dominant variant in over 190 countries worldwide through the first part of 2022, which is influencing the infectivity, transmissibility, pathogenicity, and severity of COVID‐19 pandemic. Additionally, clinical cases and experimental studies have reported that Omicron variant likely leads to weakened immune protection elicited by infection, antibody therapies, and vaccines. The new wave, from late February, 2022, was escalated abruptly by higher levels of transmission of Omicron BA.2 sublineage in China.Methods and ResultsFollowing a systematic database search, this review summarizes the salient features of Omicron sublineages, and their impact on transmissibility, disease severity as well as the efficacy of the available vaccines and treatment against the Omicron.ConclusionWe hope this study will provide a scientific reference for alleviating the burden of COVID‐19.