bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survival benefit of surgical resection for stage IV gastric cancer: A SEER-based propensity score-matched analysis
Authors: Sun Jianhui , Nan Qiong 
Published: October 2022

BackgroundGastric cancer (GC) is a major malignancy worldwide, and its incidence and mortality rate are increasing year by year. Clinical guidelines mainly use palliative drug combination therapy for stage IV gastric cancer. In accordance with some small sample studies, surgery can prolong survival. There is no uniform treatment plan for stage IV gastric cancer. This study focused on collecting evidence of the survival benefit of cancer-directed surgery (CDS) for patients with stage IV gastric cancer by analyzing data from a large sample.MethodsData on patients with stage IV gastric cancer diagnosed between 2010 and 2015 was extracted and divided into CDS and no-CDS groups using the large dataset in the Surveillance, Epidemiology, and End Results (SEER) database. With bias between the two groups minimized by propensity score matching (PSM), the prognostic role of CDS was studied by the Cox proportional risk model and Kaplan-Meier.ResultsA total of 6,284 patients with stage IV gastric cancer were included, including 514 patients with CDS who were matched with no-CDS patients according to propensity score (1:1), resulting in the inclusion of 432 patients each in the CDS and no-CDS groups. The results showed that CDS appeared to prolong the median survival time for stage IV gastric cancer (from 6 months to 10 months). Multifactorial analysis showed that poorly differentiated tumors (grades III-IV) significantly affected patient survival, and chemotherapy was a protective prognostic factor.ConclusionThe findings support that CDS can provide a survival benefit for stage IV gastric cancer. However, a combination of age, underlying physical status, tumor histology, and metastatic status should be considered when making decisions about CDS, which will aid in clinical decision-making.
The turbocharged wide anterolateral thigh perforator flap to reconstruct massive soft tissue defects in traumatized lower extremities: A case series
Authors: Jeong Seong-Ho , Koo Do-Yoon , Moon Kyung-Chul , Dhong Eun-Sang , Han Seung-Kyu 
Published: October 2022

BackgroundExtensive traumatic soft tissue defects in the lower extremities typically require complete coverage of exposed bone because inadequate coverage, such as partial flap loss, may result in bony infection and ultimately lead to limb salvage failure. To achieve complete coverage of these defects, we used the wide anterolateral thigh perforator flap in which the turbocharging procedure augments the blood flow. Herein, we describe our turbocharging technique and discuss its effectiveness.MethodsFrom January 2014 to December 2020, the turbocharged wide ALTP free flaps were used to treat 13 patients with massive traumatic soft tissue defects in the lower extremities, ranging in size from 22 × 10 cm2 (220 cm2) to 21 × 17 cm2 (357 cm2) (mean, 270 cm2). All ALTP flaps were supplied by perforators from both the transverse branch of the lateral circumflex artery (TB-LCFA) and descending branch of the lateral circumflex artery (DB-LCFA) simultaneously. The turbocharging procedure by connecting the TB-LCFA to a side branch of the DB-LCFA was carried out in all these flaps. A retrospective review of medical records for each patient was performed.ResultsThe size of the transferred ALTP flap ranged from 23 × 12 cm2 (276 cm2) to 23 × 19 (437 cm2) (mean, 331 cm2). The total number of perforators included in the flaps was three on average. All ALTP flaps survived completely without partial necrosis. The postoperative course was uneventful except for two cases with minor complications, including hematoma and partial necrosis of the recipient's skin.ConclusionFree transfer of the turbocharged wide ALTP flap can be a reliable and effective reconstructive method to obtain complete coverage of extensive traumatic soft tissue defects in the lower extremities and achieve successful limb salvage.
Th1, Th2, and Th17 cells and their corresponding cytokines are associated with anxiety, depression, and cognitive impairment in elderly gastric cancer patients
Authors: Zhou Yanxia , Yu Ke 
Published: October 2022

ObjectiveT helper (Th) cells modulate the stress response, oxidative stress, and neuroinflammation to mediate anxiety, depression, and cognitive impairment. This study intended to explore the association between Th cells and anxiety, depression, and cognitive impairment in elderly gastric cancer patients.MethodsTotally, 176 elderly gastric cancer patients were enrolled in this study. Peripheral blood samples were collected. Th1, Th2, and Th17 cells were detected by flow cytometry; their corresponding cytokines were examined by ELISA. The Hospital Anxiety and Depression Scale (HADS) and Mini-Mental State Examination (MMSE) were assessed.ResultsIn total, 42.0%, 33.0%, and 19.9% of elderly gastric cancer patients presented anxiety, depression, and cognitive impairment, respectively. Th1 (P = 0.016), Th17 (P = 0.009), and IL-17A (P = 0.001) were positively associated with the HADS-A score. Th17 (P = 0.003) and IL-17A (P = 0.009) levels were increased in patients with anxiety compared with those without anxiety. Concurrently, a positive association was observed for Th1 (P = 0.027), Th17 (P = 0.014), and IFN-γ (P = 0.049) with the HADS-D score. Th1 (P = 0.017) and Th17 (P = 0.049) levels were increased in patients with depression than in those without depression. Moreover, Th1 (P = 0.003), Th17 (P &lt; 0.001), IFN-γ (P = 0.014), and IL-17A (P &lt; 0.001) were inversely related to MMSE scores, but only Th17 (P &lt; 0.001) and IL-17A (P &lt; 0.001) were increased in patients with cognitive impairment compared with those without cognitive impairment.ConclusionTh1 and Th17 cells reflect anxiety, depression, and cognitive impairment risk to a certain extent in elderly gastric cancer patients, implying their involvement in the pathology of the abovementioned psychological and cognitive issues. However, further validation is needed.
Tensile Properties of As-Built 18Ni300 Maraging Steel Produced by DED
Authors: Gil Jorge , Seca Ricardo , Amaral Rui , Emadinia Omid , De Jesus Abílio , Reis Ana 
Published: October 2022

The mechanical behaviour of as-built DED-produced 18Ni300 Maraging steel was studied by manufacturing a wall-like structure from which three different specimen types were obtained: specimens in which the loading direction was the same as the printing direction (vertical), specimens in which these two directions were perpendicular (horizontal), and bimetallic specimens in which the interface between the AISI 1045 substrate and the 18Ni300 steel was tested. The yield strength of the produced samples was 987.9±34.2, 925.9±89.7 and 486.7±47.2 MPa for the vertical, horizontal and bimetallic specimens, respectively, while the elongation to failure was 9.4±1.9, 18.3±2.3 and 14.06±0.6% in the same order. The latter specimen failed within the substrate-comprised portion of the specimen. Additionally, the fracture surfaces were analysed through scanning electron microscopy, concluding that while both surfaces consist of dimples, the horizontal specimen presented microporosities with a reduced diameter. A microhardness analysis in the printed wall-like structure following the printing direction yielded an average hardness of 392±21 HV0.3, with fluctuations along the build direction mostly within one standard deviation.
Application of Artificial Intelligence for Predicting Real Estate Prices: The Case of Saudi Arabia
Authors: Alzain Elham , Alshebami Ali Saleh , Aldhyani Theyazn H. H. , Alsubari Saleh Nagi 
Published: October 2022

The housing market is a crucial economic indicator to which the government must pay special attention because of its impact on the lives of freshly minted city inhabitants. As a guide for government regulation, individual property purchases, third-party evaluation, and understanding how housing prices are distributed geographically may be of great practical use. Therefore, much research has been conducted on how to arrive at a more accurate and efficient way of calculating housing prices in the current market. The goal of this study was to use the artificial neural network (ANN) technique to correctly identify real estate prices. The novelty of the proposed research is to build a prediction model based on ANN for predicting future house prices in Saudi Arabia. The dataset was collected from Aqar in four main Saudi Arabian cities: Riyadh, Jeddah, Dammam, and Al-Khobar. The results showed that the experimental and predicted values were very close. The results of the proposed system were compared with different existing prediction systems, and the developed model achieved high performance. This forecasting system can also help increase investment in the real estate sector. The ANN model could appropriately estimate the housing prices currently available on the market, according to the findings of the assessments of the model. Thus, this study provides a suitable decision support or adaptive suggestion approach for estimating the ideal sales prices of residential properties. This solution is urgently required by both investors and the general population as a whole.
Photobiomodulation with 808nm laser associated with vitamin B12 as a strategy in the treatment of paresthesia of the inferior alveolar and lingual nerve arising from lower third molar extraction: a case report
Authors: Da Silva Amorim Raysa Nyara , Tenore Gianluca , Romeo Umberto , Ferrari Giulia , Queiroz de Paula Marcos Vinicius 
Published: October 2022

Introduction: Paresthesia is a neurosensitive disorder caused by an injury of the neural tissue. The advised treatment approaches for paresthesia are microsurgery, drug treatment, acupuncture, nerve decompression and photobiomodulation (PBM). Studies have shown the influence of PBM on cellular metabolism, in order to exert a positive action at molecular levels, relieving pain, reducing nerve damage and accelerating neural tissue repair processes. Objective: To report a clinical case of a patient diagnosed with paresthesia submitted to PBM treatment and medication consisting of vitamin B12. Case Report: The patient reported sensory loss of the tongue, lips, lower alveolar ridge on the right side and hypogeusia in the immediate post operative care period. The patient was diagnosed with paresthesia of the inferior alveolar and lingual nerves and submitted to PBM treatment during a period of 6 months. Conclusion: PBM in the innervation pathway affected by paresthesia demonstrates effectiveness for sensory improvement. This work illustrates treatment options that can be used in similar clinical manifestations.
Eusébio de Cesaréia e o martírio como estratégia pedagógica
Authors: Nunes Pinheiro Tiago , Henrique Santin Rafael , Oliveira Terezinha 
Published: October 2022

Eusébio de Cesaréia (265-339), mais conhecido como pai da História da Igreja por causa de sua mais famosa obra, História Eclesiástica. O objetivo da nossa pesquisa, intitulada Eusébio de Cesaréia e o Martírio como estratégia pedagógica, é analisar alguns episódios de martírio narrados na obra Historia Eclesiástica, pois acreditamos que por meio desse estudo teremos a oportunidade de compreender como o cristianismo se colocou como um modelo educativo que buscava restaurar a ordem imperial prestes a ruir. É fundamental observarmos que seguimos os trilhos da História Social que se baseiam principalmente nas contribuições da Escola dos Annales para a história e a historiografia.

Palavras-chave: História da Educação; Eusébio de Cesaréia; História Eclesiástica; Martírio.
O antídoto do espiritismo para a psicopatologia da morte
Authors: Fernandes Carlos Roberto , Da Silva Emanuelly Pereira 
Published: October 2022

A morte ainda provoca nas pessoas em geral estados mentais variados, dentre eles a descrença, a desesperança, a angústia espiritual, o sofrimento mental-moral-espiritual, o medo, a ansiedade, a tristeza crônica. Nesse contexto e considerando-se a vivência do processo de morrer e da morte por profissionais de Enfermagem, espiritualidade e cuidado são abordagens utilizadas no âmbito terapêutico para prevenir, interromper e superar possíveis quadros psicopatológicos no processo de morrer e diante da morte. O acervo bibliográfico e mediúnico de Chico Xavier tem uma vertente particular de livros de mensagens, atribuídas a familiares mortos. Quem são os espíritos familiares comunicantes, qual o quantitativo dessas comunicações, dados dos comunicantes, em que obras foram publicadas e quais são os possíveis quadros psicopatológicos de pais e de mães que os fizeram buscar socorro espiritual e mediúnico? OBJETIVO: - sistematizar as obras de cartas familiares, recebidas mediunicamente por Chico Xavier, entre 1951 e 2012; - explicitar os possíveis quadros psicopatológicos de pais e de mães e sua superação após o recebimento das cartas psicografadas. MÉTODO: a pesquisa tem abordagem histórica, a fonte é documental, a técnica de coleta de dados é bibliográfica, a técnica de análise é quantitativa. RESULTADOS: a) 74 livros temáticos publicados entre 1951 e 2012, 550 espíritos familiares comunicantes, 1726 cartas mediúnicas escritas, 61 espíritos comunicantes excluídos por falta de dados biográficos registrados. b) maior quantitativo das causas de morte é acidente automobilístico e de motocicleta, assassinato com arma de fogo, afogamento, parada cardíaca e suicídio. CONCLUSÃO: As obras psicografadas por Chico Xavier, referentes a cartas familiares de desencarnados a encarnados, conforme depoimentos unânimes dos próprios familiares, são antídotos para a redução ou cessação das incertezas e possíveis sofrimentos psicopatológicos durante o processo de morrer e diante da morte.
PALAVRAS CHAVE: Espiritismo, Morte, Psicopatologia, Religião.
Aproximações entre as metodologias ativas e as teorias da aprendizagem
Authors: Nascimento Thiago Jovane , Paim Marilane Maria Wolff 
Published: October 2022

Este artigo trata das metodologias ativas e das teorias da aprendizagem. Com o objetivo de compreender as bases teóricas que fundamentam as metodologias denominadas peer instruction, mapas mentais/conceituais e a aprendizagem baseada em problemas/projetos, realizou-se uma pesquisa bibliográfica (FACHIN, 2006). Foram identificadas as seguintes teorias que embasam as metodologias ativas em questão, respectivamente: behaviorismo (teoria comportamentalista), epistemologia genética (teoria piagetiana) e abordagem sociointeracionista (teoria histórico-cultural), sendo esta última também próxima da pedagogia freiriana. O confronto de tais metodologias com suas bases teóricas, ao lado da análise do papel do professor e da avaliação nos processos educativos, apontam para um posicionamento epistemológico contrário à abordagem multimetodológica na educação. Conclui-se salientando para uma compreensão das teorias que sustentam os métodos, pois o uso de métodos e técnicas de maneira isolada e aleatória pode ser prejudicial para o sucesso dos processos educativos.
E-Learning Teaching: Supportive Online Course ‘English Fastpass’
Authors: Kostikova Ilona , Miasoiedova Svitlana 
Published: October 2022

The aim of this paper is to prove the hypothesis that in order to cope with the adversities and hardships and meet the demands of the wartime and pandemic challenges, a complex of tools and techniques has to be applied including new teaching strategies with the use of multimedia, mobile applications and employing learning possibilities of social networking sites, Google classroom tools and other instruments with online course “English Fastpass”.
Methodology. In this research theoretical, empirical and statistical methods are used. Theoretical methods (analysis and synthesis) serve to analyze opportunities, advantages and disadvantages of social media as a new tool of teaching. Empirical ones (observation, testing, pedagogical experiment) provide conducting the experiment itself. Statistical methods (one sample t-test) helped make statistical analysis of the pedagogical experimental data.
Results. The complex of tools and techniques to teach English is implemented effectively by online course “English Fastpass” aimed at preparing students for passing English Exam. The offered extra-class activities are definitely very successful: daily vocabulary and grammar tasks followed by weekly online analysis; challenges (one-week of three-week activities focused on improving general English proficiency and cultural awareness); exam boosters focused on practicing a particular exam task type; monthly webinars; quizzes and games. The resulting experimental data showed the significant progress in students' performance in both linguistic and intercultural competences, and specifically in use of English tasks. The final assessment in all English language practical skills, including the competence in intercultural communication, confirmed considerable advance of the all-language competences.
Conclusion. The effectiveness of applying different unconventional extra-class activities is proven. They are followed by weekly online analysis. The most helpful of them for learning process are exam boosters, monthly webinars, quizzes and games. Using the visualisation techniques, influencing students' emotions and feelings, the abovementioned online course “English Fastpass” facilitates efficient acquisition and better memorizing along with the ability to use the knowledge in the appropriate tasks, which in the long run will help successful intercultural communication. Judging by the comments made by the students they would find such methods of teaching extremely encouraging and stimulating.
Justification of the Educators’ New Professional Functions under the Conditions of Martial Law
Authors: Trubavina Iryna , Cherednychenko Oleksandr , Oliinyk Nadiia , Nedria Kirill 
Published: October 2022

The article is devoted to actual problem of today's pedagogical theory: the new functions of educators in the conditions of martial law. Based on a reviewof foreign and native sources, the generalization of experience in Ukraine and beyond, the authors achieve the purpose. The purpose is to define the new functions of educators in the conditions of martial law and to fill in the existing ones with new content. The research is based on competence, activity, environmental, socio-pedagogical, safety approaches.
Methodology. The research is based on competence, activity, environmental, socio-pedagogical, safety scientific approaches. Research methods are: theoretical analysis of sources, generalization, observation, conversations, establishment of cause and effect relationships. The materials of the research were domestic and foreign works on education methodology, safety in education, our experience of teaching at teacher training programs.
Results. We observe an increase in the functions of educators under martial law. It is logical to add to the traditional functions of the school principal: security function, organization of social support and assistance; social adaptation; personnel management and implementation of a sustainable personnel policy in institution of general secondary education; preventive function, the function of cohesion an dunity of the school team and the population in the community; national-patriotic; organizational; financial management in institution of general secondary education; informative. Teachers in the conditions of martial law were also faced with the need to perform the following new functions: socio-pedagogical (helping children to solve problems of socialization in conditions of martial law, family distance); social adaptation and integration of families with children in the conditions of the host community; social prevention of negative phenomena in the educational environment; information about resources to help in the community; social support and assistance to families with children in the conditions of an educational institution – a temporary shelter for families; pre-medicalcare; promotion of national security through increased attention to national-patriotic education.
Conclusions. Our research shows that all teaching staff of educational institutions and their principals in the conditions of martial law begins to perform additional functions and new tasks due to the peculiarities of the martial law in education and new threats to children and all other participants of the educational process, requirements to ensure national security. It requires updating the list and expanding the content of educators’ functions under martial law. That is why these questions should be included in the professional standards of the principal and the teacher of the institution of general secondary education, in educational programs of various levels, which will be the prospects of our further research.
KUALITAS ORGANOLEPTIK DAGING SE’I YANG DIOLAH DARI DAGING SAPI BALI BETINA AFKIR (Organoleptic quality of se’i made from bali cull cow beef)
Authors: Adjam Kiki R. , Malelak Gemini E.M. , Sabtu Bastari 
Published: October 2022

Aim of this study was to evaluate quality of se’i (Rotennese smoke meat) made from cull Bali cow meat. Completely randomized design 3x3 was used in this study. Meat taken from cull Bali cow with body condition skore (BCS) 2 (thin), 3 (moderate) and 4 (slightly fat). Each BCS had three replicates. Parameters observed included taste, color, aroma, pH value and fat oxidation. The results showed that BCS had a highly significant effect (P <0.01) on color and taste, had a significant effect (P <0.05) on fat oxidation, had no significant effect (P> 0.05) on aroma and pH. Se,i made from BCS 4 had a slightly dark red color, the best taste and the highest fat oxidation rate, whereas se'i prepared from BCS 3 has a slightly dark red color, medium taste and lowest fat oxidation rate. It is concluded that the best quality of se’i produced in this study was made from BCS 4,however, it was necessary to add antioxidants to retard fat oxidation rate. Whereas if used BCS 3 it is better to add some additives to improve the taste.
PERFORMA REPRODUKSI SAAT LAHIR DAN SAPIH DARI INDUK KAWIN DENGAN PEJANTAN DUROC DAN LANDRACE (Reproduction performance at birth and weaning age of sows mating with duroc and landrace studs)
Authors: Djego Yohanes , Kune Petrus , Nada  Kihe Johny 
Published: October 2022

This research aim was to know reproduction performances at birth and weaning age of the sows which were mated with Duroc and Landrace studs. The research was carried out in two breeding farms namely the Instalation of Pig Breeding, the village of Tarus, Kupang Regency and the Manise Pig Farm, Village of Oetete, Kupang City. There were two breeds of studs namely breed of Landrace and Duroc which each stud was mated to 15 breeding pigs. The method used in this research was a survey and the samples were collected purposively. Data collection were obtained when the piglets were born and weaned. The variables were the litter size and body weight at birth age and the liter size and body weight at weaning age. The data obtained was analysed using the t test (t-test). The results showed that the characters of birth litersize,birth body weight, weaning litter size and weaning weight for Duroc stud were 10.60±2.41 head, 1.95±0.18 kg/head; 10.00±2.02 head and 5.98±0.65kg/head, respectively and those charackters for Landarace stud were 9.06±2.09head, 1.98 ±0.22 kg/head; 8.93± 2.23 head and 6.20±0.28 kg/head, respectively. Results of statistical analysed showed that Duroc and Landrace studs did not effect significantly (P>0.5) for those charackters. Reproduction performances of sows that were mated with Duroc and Landrace studs for characters of birth liter size, birth weight, weaning liter size and weaning weight were relatively similar.