bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient satisfaction with telephone consultations at a community mental health service: a descriptive survey
Authors: Naik Kshipra Vissucanta , Allen Lucy , Gnanavel Muthukkumaar 
Published: November 2022

Background/Aims Research has demonstrated that there are several models of teleconsultation, and that these can be effective and acceptable to patients. At the start of the COVID-19 pandemic, there was a sudden shift to phone consultations in community mental health services. This study assessed the impact of this change from the patient perspective and thus determined how this mode of delivery can be optimised going forwards. Method Data were collected using a semi-structured, self-reporting patient satisfaction questionnaire with 17 items, which was sent to 200 patients who had received both an in-person and telephone consultation from a community mental health team in Wales. The themes covered in the questionnaire were communication, interpersonal manner, technical quality, convenience and general satisfaction. A total of 114 respondents rated their agreement with the items on a 5-point Likert scale, and free-text boxes were provided for suggestions and comments. Quantitative data were summarised using descriptive statistics and free-text comments were analysed thematically. Results The majority of the patients gave positive responses, with 70–94% either agreeing or strongly agreeing with the positive statements regarding the communication, interpersonal manner, technical quality and length of consultation that they experienced. Overall, 74% agreed or strongly agreed that they were generally satisfied. However, only 52% believed that telephone consultations were more convenient than in-person hospital appointments, and nearly one-quarter (24%) did not want to continue with telephone consultations in the future. Suggested improvements included the use of video consultations, provision of extra time for consultations and a general increase in the services available. Conclusions Telephone consultations were generally perceived as acceptable, useful and effective, helping patients to access ongoing mental health care. This suggests that telephone consultations could be an effective method of care delivery in the future. However, there is a need for further research and development in the remote delivery of mental health services.
The influence of psychiatric comorbidities on the duration of compulsory nasogastric tube feeding of children and adolescents with restrictive eating disorders
Authors: Fuller Sarah J , Falcoski Paola Moraes Sarmento Freitas , Hudson Lee D , Tan Jacinta OA 
Published: November 2022

Background/aims The authors' clinical experience found that some patients required the intervention of compulsory nasogastric tube feeding for a significantly longer amount of time than others. The aim of this study was to identify whether different psychiatric comorbidities are associated with different durations of nasogastric tube feeding under restraint in children and young people with restrictive eating disorders. Methods A retrospective case-note analysis was conducted in 2018. Data were collected from electronic medical records and hospital incident forms, focusing on diagnosis, length of stay and on the number of episodes of nasogastric tube feeding under restraint. Results A total of nine patients required nasogastric tube feeding under restraint, of which four patients had psychiatric comorbidities (emerging emotionally unstable personality disorder, autism spectrum disorder and complex trauma). Length of stay was not significantly greater in patients with psychiatric comorbidities (median=302 vs 241 days, Mann-Witney U=16.00, P=0.20). However, the number of episodes of nasogastric tube feeding under restraint was significantly greater in those with psychiatric comorbidities (median=31.00 vs 2 episodes, Mann-Whitney U=20.00, P=0.02) than those without. Conclusions This study suggests that psychiatric comorbidities are associated with more prolonged episodes of nasogastric tube feeding under restraint and therefore patients with these comorbidities will have greater treatment planning needs.
Variations in long-term care home resident hospitalizations before and during the COVID-19 pandemic in Ontario
Authors: Jones Aaron , Mowbray Fabrice I. , Falk Lindsey , Stall Nathan M. , Brown Kevin A. , Malikov Kamil , Malecki Sarah L. , Lail Sharan , Jung Hae Young , Costa Andrew P. , Verma Amol A. , Razak Fahad 
Published: November 2022

Objectives
To examine how the COVID-19 pandemic affected the demographic and clinical characteristics, in-hospital care, and outcomes of long-term care residents admitted to general medicine wards for non-COVID-19 reasons.

Methods
We conducted a retrospective cohort study of long-term care residents admitted to general medicine wards, for reasons other than COVID-19, in four hospitals in Toronto, Ontario between January 1, 2018 and December 31, 2020. We used an autoregressive linear model to estimate the change in monthly admission volumes during the pandemic period (March-December 2020) compared to the previous two years, adjusting for any secular trend. We summarized and compared differences in the demographics, comorbidities, interventions, diagnoses, imaging, psychoactive medications, and outcomes of residents before and during the pandemic.

Results
Our study included 2,654 long-term care residents who were hospitalized for non-COVID-19 reasons between January 2018 and December 2020. The crude rate of hospitalizations was 79.3 per month between March-December of 2018–2019 and 56.5 per month between March-December of 2020. The was an adjusted absolute difference of 27.0 (95% CI: 10.0, 43.9) fewer hospital admissions during the pandemic period, corresponding to a relative drop of 34%. Residents admitted during the pandemic period had similar demographics and clinical characteristics but were more likely to be admitted for delirium (pandemic: 7% pre-pandemic: 5%, p = 0.01) and were less likely to be admitted for pneumonia (pandemic: 3% pre-pandemic: 6%, p = 0.004). Residents admitted during the pandemic were more likely to be prescribed antipsychotics (pandemic: 37%, pre-pandemic: 29%, p <0.001) and more likely to die in-hospital (pandemic:14% pre-pandemic: 10%, p = 0.04)

Conclusions and implications
Better integration between long-term care and hospitals systems, including programs to deliver urgent medical care services within long-term care homes, is needed to ensure that long-term care residents maintain equitable access to acute care during current and future public health emergencies.
Total neoadjuvant therapy versus standard therapy in locally advanced rectal cancer: A systematic review and meta-analysis of 15 trials
Authors: Zhang Xiping , Ma Shujie , Guo Yinyin , Luo Yang , Li Laiyuan 
Published: November 2022

Background
Neoadjuvant chemoradiotherapy (nCRT) before total mesorectal excision (TME) and followed systemic chemotherapy is widely accepted as the standard therapy for locally advanced rectal cancer (LARC). This meta-analysis was to evaluate the current evidence regarding nCRT in combination with induction or consolidation chemotherapy for rectal cancer in terms of oncological outcomes.

Methods
A systematic search of medical databases (PubMed, EMBASE and Cochrane Library) was conducted up to the end of July 1, 2021. This meta-analysis was performed to evaluate the efficacy of TNT in terms of pathological complete remission (pCR), nCRT or surgical complications, R0 resection, local recurrence, distant metastasis, disease-free survival (DFS) and overall survival (OS) in LARC.

Results
Eight nRCTs and 7 RCTs, including 3579 patients were included in the meta-analysis. The rate of pCR was significantly higher in the TNT group than in the nCRT group, (OR 1.85, 95% CI 1.39–2.46, p < 0.0001), DFS (HR 0.80, 95% CI 0.69–0.92, p = 0.001), OS (HR 0.75, 95% CI 0.62–0.89, p = 0.002), nCRT complications (OR 1.05, 95% CI 0.77–1.44, p = 0.75), surgical complications (OR 1.02, 95% CI 0.83–1.26, p = 0.83), local recurrence (OR 1.82, 95% CI 0.95–3.49, p = 0.07), distant metastasis (OR 0.77, 95% CI 0.58–1.03, p = 0.08) did not differ significantly between the TNT and nCRT groups.

Conclusion
TNT appears to have advantages over standard therapy for LARC in terms of pCR, R0 resection, DFS, and OS, with comparable nCRT and postoperative complications, and no increase in local recurrence and distant metastasis.
Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study
Authors: Kyohara Mayu , Miyashita Daisuke , Inoue Ryota , Nishiyama Kuniyuki , Tsuno Takahiro , Okuyama Tomoko , Togashi Yu , Terauchi Yasuo , Shirakawa Jun 
Published: November 2022

Plasma and liver SerpinB1 levels are elevated in mice with insulin resistance and promote β-cell proliferation in human islets. We measured serum SerpinB1 levels in Japanese subjects with or without type 2 diabetes (T2DM). We enrolled 12 normal glucose tolerance (NGT) and 51 T2DM subjects. There was no difference in serum SerpinB1 levels between the 2 groups (T2DM, 1.3 ± 0.9 ng/mL vs. NGT, 1.8 ± 1.7 ng/mL; P = 0.146). After adjusting for age and sex, the serum SerpinB1 levels were positively correlated with HOMA2-%S (β = 0.319, P = 0.036), and negatively correlated with fasting blood glucose (β = -0.365, P = 0.010), total cholesterol (β = -0.396, P = 0.006), low-density lipoprotein (LDL) cholesterol (β = -0.411, P = 0.004), triglycerides (β = -0.321, P = 0.026), and γGTP (β = -0.322, P = 0.026) in subjects with T2DM. Thus, circulating SerpinB1 is possibly associated with insulin sensitivity and better blood glucose level in Japanese subjects with T2DM.
Trial registration: UMIN Clinical Trials Registry, UMIN000020453.
Educational intervention and livestock ownership successfully improved the intake of animal source foods in 6–23 months old children in rural communities of Northern Ethiopia: Quasi-experimental study
Authors: Haileselassie Mekonnen , Redae Getachew , Berhe Gebretsadik , Henry Carol J. , Nickerson Michael T. , Mulugeta Afework 
Published: November 2022

Background
Animal source foods (ASFs) are rich in high-quality proteins, including essential amino acids and highly bioavailable micronutrients vital for child growth and cognitive development. But, the daily consumption of ASFs among 6–23 months old children is very low in Tigray, Northern Ethiopia.

Objective
The study aimed to assess the effectiveness of nutrition education intervention to improve the consumption of ASFs among 6–23 months old children from rural communities with strict religious fasting traditions of avoiding intake of ASFs in Northern Ethiopia.

Methods
A quasi-experimental study was conducted in two food insecure districts namely Samre Seharti (intervention) and Tanqua Abergele (comparison). The mother-child pairs in the intervention group (n = 140) received nutrition education based on the barriers and available resources for optimal consumption of ASFs among children and followed up for nine months. The mother-child pairs in the comparison group (n = 153) received routine nutrition education. The data were collected using a pre-tested structured questionnaire. The baseline and endline data assessment included interviews on socio-demographic and socio-economic status, dietary intake, and child feeding practices. The effectiveness of the intervention was measured using the difference-in-difference (DID) analysis model.

Results
At endline, the consumption of ASFs among children was 19.5 percentage points higher in the intervention group compared with the comparison group (p = 0.008). In addition, there was a significant increase in egg consumption among children in the intervention group (DID of 16.9, p = 0.012) from the comparison group. No child was consuming meat at baseline in both the intervention and comparison arms and it was very low at endline (5.2% vs. 7.9%). Overall, the proportion of children that consumed eggs in the intervention group was higher than in the comparison group in households that owned sheep and goats (4.8% vs. 21.4%, p = 0.050) and chicken (6.3% vs. 43.8%, p = 0.002) after education interventions. However, no statistically significant difference was observed between cow ownership and milk consumption among children (p>0.05).

Conclusions
Age-appropriate educational interventions for mothers and owning small livestock in the household can improve the consumption of ASFs and eventually the minimum diet diversity of children in communities with strict religious traditions of avoiding ASFs during the fasting seasons.
Impact of early initiation of sodium-glucose cotransporter 2 inhibitor on cardiovascular outcomes in people with diabetes and known or at risk of atherosclerotic cardiovascular disease: Propensity score matched analysis
Authors: Sun Wen , Kong Alice P. S. , Yan Bryan P. 
Published: November 2022

Objective
We aimed to evaluate the impact of early initiation of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on cardiovascular (CV) outcomes in people with type 2 diabetes (T2D) with known or at risk of atherosclerotic cardiovascular disease (ASCVD).

Research design and methods
T2D with first prescription of SGLT2i (Dx-to-Rx time) ≤12 months were matched with >12 months using propensity score derived from logistic regression. T2D were divided into 3 groups: (i) known ASCVD; (ii) additional CV risk factor(s) and; (iii) without ASCVD or additional CV risk factors. Incidence rates of 3-point major adverse cardiovascular events (MACE, including non-fatal stroke, non-fatal myocardial infarction and CV death) were compared between Dx-to-Rx time ≤12 months and >12 months across 3 subgroups.

Results
Median follow-up was 2.8 years (IQR 2.2 to 3.4). Among 29,309 T2D (mean age 57.6±11.4 years, 59.0% men), 23.6% had established ASCVD and 66.6% had additional CV risk factors. Overall, 19.0% of patients had Dx-to-Rx time ≤12 month which was associated with lower rates of MACE [hazard ratio (HR) = 0.27, 95%CI: 0.17–0.42]. Benefits of early initiation of SGLT2i was observed in patients with additional CV risk factors or known ASCVD but not in those without CV risk factors or ASCVD (P for interaction = 0.001).

Conclusion
Early initiation of SGLT2 inhibitor was associated with lower MACE rates in T2D with known or at risk of ASCVD.
Contested Space and Self-Determination: The Dynamics of Ethiopia's Digital Space
Authors: Wodajo Kebene 
Published: November 2022

Abstract
Government-to-people and people-to-people relationships are increasingly mediated and configured by emerging technologies, necessitating new ways of framing and understanding the role of government and digital technologies in the social order. Recent sociopolitical developments in Ethiopia demonstrate how digital platforms have become a space for contested narratives and a division of interests between socioeconomic policies and political views. By addressing the major technologically assisted counterpower movements in Ethiopia between 2015 and 2021, this article examines digitally mediated encounters and configurations that are struggling to produce a specific form of subjectivity. The article examines digitally mediated encounters and the patterns of the relationships among main actors in the digital space—users, the government, and platform technologies—through the lens of the network theory of power. The article problematizes the deployment of state surveillance, rulemaking and regulatory leverages, and the gatekeeping role of platform technologies in modulating and suppressing the emergence of a self-determined critical mass. As a remedial approach to addressing the risks inherent in intersecting state–corporate configuration and surveillance, the article proposes a broadly defined yet context-specific right to privacy that enables self-development, protects a socially and culturally constructed emergent self, and encourages the capacity for self-determination. To analyze the right to privacy as a remedy, the study uses a critical legal analysis of privacy rights with a focus on the 1995 Ethiopian Constitution. Throughout the analysis, it seeks to highlight three overarching arguments that have relevance beyond the specific case of Ethiopia. First, it challenges the assumption that the digital space is a neutral and free space. It argues that digital platforms provide venues for contested and rival narratives and interests, and that not every actor in the digital space has equal leverage over the digital infrastructure. The digital space therefore manifests an asymmetric power relationship. Second, it argues that the capacity of citizens for self-development and self-determination is increasingly modulated by expansive surveillance and the regulatory leverage of state and corporate power, which is used to suppress the emergence of critical mass. It therefore argues that third, there is a pressing need for the reinterpretation of legal protection for privacy rights as a protection for a socially and culturally constructed emergent self. By addressing this need, protection will be offered to the capacity for self-determination, critical subjectivity and democracy.
The History of the Passage of Legislation Authorizing the Optometric Use of Drugs for Diagnostic Purposes in Alabama
Authors: Amos, OD, MS, DOS John F. 
Published: November 2022

This article recalls events that led to the passage of legislation authorizing the use of drugs for diagnostic purposes by optometrists in other states prior to the law’s passage in the State of Alabama. Some states authorized optometrists to utilize drugs for diagnostic purposes by state statue and others by attorney general’s ruling. In Alabama a new state optometry practice act was passed in 1975. This law was complex and confusing, and of equal importance, resulted in a series of attorney general’s opinions, after the new state optometry practice act was passed. A series of Attorney General’s opinions shifted between a favorable, or an unfavorable, opinion over the next seven years. Finally, in 1982, the Attorney General issued a final determination that resulted in a favorable opinion for optometry. During the ensuing years no lawsuits were brought against optometrists that involved the use of drugs for diagnostic purposes.
A deep learning network for Gleason grading of prostate biopsies using EfficientNet
Authors: Ramamurthy Karthik , Varikuti Abinash Reddy , Gupta Bhavya , Aswani Nehal 
Published: November 2022

Abstract

Objectives
The most crucial part in the diagnosis of cancer is severity grading. Gleason’s score is a widely used grading system for prostate cancer. Manual examination of the microscopic images and grading them is tiresome and consumes a lot of time. Hence to automate the Gleason grading process, a novel deep learning network is proposed in this work.

Methods
In this work, a deep learning network for Gleason grading of prostate cancer is proposed based on EfficientNet architecture. It applies a compound scaling method to balance the dimensions of the underlying network. Also, an additional attention branch is added to EfficientNet-B7 for precise feature weighting.

Result
To the best of our knowledge, this is the first work that integrates an additional attention branch with EfficientNet architecture for Gleason grading. The proposed models were trained using H&E-stained samples from prostate cancer Tissue Microarrays (TMAs) in the Harvard Dataverse dataset.

Conclusions
The proposed network was able to outperform the existing methods and it achieved an Kappa score of 0.5775.
The preanalytical phase – from an instrument-centred to a patient-centred laboratory medicine
Authors: Cadamuro Janne , Simundic Ana-Maria 
Published: November 2022

Abstract
In order to guarantee patient safety, medical laboratories around the world strive to provide highest quality in the shortest amount of time. A major leap in quality improvement was achieved by aiming to avoid preanalytical errors within the total testing process. Although these errors were first described in the 1970s, it took additional years/decades for large-scale efforts, aiming to improve preanalytical quality by standardisation and/or harmonisation. Initially these initiatives were mostly on the local or national level. Aiming to fill this void, in 2011 the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) working group “Preanalytical Phase” (WG-PRE) was founded. In the 11 years of its existence this group was able to provide several recommendations on various preanalytical topics. One major achievement of the WG-PRE was the development of an European consensus guideline on venous blood collection. In recent years the definition of the preanalytical phase has been extended, including laboratory test selection, thereby opening a huge field for improvement, by implementing strategies to overcome misuse of laboratory testing, ideally with the support of artificial intelligence models. In this narrative review, we discuss important aspects and milestones in the endeavour of preanalytical process improvement, which would not have been possible without the support of the Clinical Chemistry and Laboratory Medicine (CCLM) journal, which was one of the first scientific journals recognising the importance of the preanalytical phase and its impact on laboratory testing quality and ultimately patient safety.
Bioleaching of heavy metals from preservative-treated wood using Aspergillus tubingensis
Authors: Oh Jeong-Joo , Kim Gyu-Hyeok 
Published: November 2022

Abstract
Although fungal bioleaching with Aspergillus niger has been investigated to remove metal from treated wood wastes, toxicological concerns limit the practical use of the species, necessitating the search for non-toxic species with comparable or greater metal removal efficiency. The removal of metals from wood treated with chromated copper arsenate (CCA) and copper amine-based preservatives was investigated using the non-ochratoxigenic mold Aspergillus tubingensis in comparison to A. niger via bioleaching. Metals were bioleached for 10 days by immersing treated wood sawdust in fungal culture filtrates. Culture filtrates were prepared by growing fungi in malt extract (ME) and sucrose media and then filtering the fungal biomass. Oxalic acid and citric acid were the predominant organic acids in A. tubingensis culture filtrate in ME and sucrose media, respectively. Citric acid present in sucrose media was found to be a more effective leaching agent for metals from preservative-treated wood. Citric acid produced by A. tubingensis and A. niger in sucrose media removed nearly 95% of copper, 80%–85% of chromium, and arsenic from CCA-treated wood, and 80%–90% of copper from wood treated with copper amine-based preservatives. As a result of its non-toxigenic characteristics and high metal removal efficiency, A. tubingensis may be a useful fungus for bioleaching metal components from inorganic preservative-treated wood.