bluuebunny/crossref_metadata_2025_split huggingface dataset:
A qualitative thematic analysis of mentorship for new psychiatric-mental health nurse practitioners
Authors: Fox Isadora , Champion Jane D. 
Published: December 2022

ABSTRACT

Background:
A volume of literature reflects that mentorship is key in producing quality nurse practitioners. Mentoring leads to increased confidence, role clarity, and other benefits improving practice. However, there is little to no research focusing specifically on the impact of mentoring in psychiatric nurse mental health nurse practitioners (PMHNPs).

Purpose:
To explore process of acquiring mentorship and mentoring experiences of newly graduated PMHNPs, all of whom obtained their respective degrees partially or completely online. The study also seeks to describe perceptions of mentoring in PMHNP leaders.

Methods:
Nine new graduate PMHNPs and 10 PMHNP leaders were recruited from membership rosters of professional organizations in the Southwestern United States. Informants participated in semi-structured interviews with questions sourced from an interview guide. Interviews were conducted via videoconference or telephone from informants' homes. Data were coded via an in vivo approach and analyzed by thematic methods.

Results:
New graduates reported that mentoring was dependent on four themes: connectivity, educational stewardship, practice confidence, and luck. Mentor access via work, institutions, or schools was inconsistent. Leaders were concerned about limited educational and professional investment in mentorship because this process is an important component of professional development.

Conclusion:
Mentorship for new graduates is based on a variety of factors, some of which are out of their control. Lack of mentoring may affect practice, which affects patient care. Dialogue between educators, professionals, and organizations may improve mentoring stewardship.

Implications:
Enhanced communication between educational institutions and professional organizations to create a more fluid process from graduate to mentorship is needed.
Detection strategies for elevated lipoprotein(a): will implementation let the genie out of the bottle?
Authors: Loh Wann Jia , Watts Gerald F. 
Published: December 2022

Purpose of review
Elevated Lp(a) level is an important causal risk factor for atherosclerotic cardiovascular disease (ASCVD), principally coronary artery disease. Selective testing for Lp(a) is highly recommended in patients at intermediate and high risk for ASCVD. Lp(a) levels are predominantly genetically determined, and this has implications for cascade testing.

Recent findings
Recent studies show that cascade testing is effective in identifying elevated Lp(a) in close relatives of probands with high Lp(a). Apart from selective testing and cascade testing as detection strategies, some recent guidelines recommend testing of Lp(a) in all adults at least once in their lifetime and various implementation strategies have been suggested.

Summary
Hyper-Lp(a) is an important global health problem that can be easily detected. Hyper-Lp(a) meets all the criteria for universal screening except that there is not yet supportive evidence from clinical interventional trials showing a reduction of ASCVD events. The cost-effectiveness of the various detection and implementation strategies need to be further evaluated.
Prediction of acute lung injury in severe acute pancreatitis by routine clinical data
Authors: Jia Mengyu , Xu Xiaorong , Zhou Shu , Liu Hua , Zhao Yan , Xu Yaping , Tang Maochun , Wu Deqing 
Published: December 2022

Aim
Acute lung injury (ALI) is a common complication of severe acute pancreatitis (SAP) with a high mortality. Early prediction of patients at risk in initial stage can improve the long-term survival.

Methods
A total of 91 patients with SAP out of 1647 acute pancreatitis patients from January 2015 to December 2020 were considered. A predictive model for SAP-associated ALI was constructed based on the valuable risk factors identified from routine clinical characteristics and plasma biomarkers. The value of the model was evaluated and compared with Lung Injury Prediction Score (LIPS). A nomogram was built to visualize the model.

Results
Diabetes, oxygen supplementation, neutrophil count and D-dimer were found to be associated with ALI in SAP. The predictive model based on these factors had an area under the receiver operating characteristic curve [AUC: 0.88, 95% confidence interval (CI): 0.81–0.95], which was superior to LIPS (AUC: 0.71, 95% CI: 0.60–0.83), also with the higher sensitivity (65%) and specificity (96%) than LIPS (62%, 74%, respectively). Decision curve analysis of the model showed a higher net benefit than LIPS. Visualization by a nomogram facilitated the application of the model.

Conclusion
Diabetes, oxygen supplementation, neutrophil count and D-dimer were risk factors for SAP-associated ALI. The combination of these routine clinical data and the model visualization by a nomogram provided a simple and effective way in predicting ALI in the early phase of SAP.
Pharmacotherapeutic efficacy on noninvasive fibrosis progression in nonalcoholic fatty liver disease: a systematic review and network meta-analysis
Authors: Kovalic Alexander J. , Gozar Martin , Da Ben L. , Bernstein David , Satapathy Sanjaya K. 
Published: December 2022

Background
Fibrosis impacts long-term outcomes among patients with nonalcoholic fatty liver disease (NAFLD). Due to well-documented flaws associated with liver biopsy, there has been a recent emphasis on prioritizing noninvasive testing over liver biopsy for the assessment of fibrosis.

Methods
A comprehensive systematic review and frequentist random effects network meta-analysis was performed among randomized controlled trials reporting pharmacologic intervention in NAFLD. The primary endpoint was the absolute change in liver stiffness measurement (LSM) via elastography. Secondary endpoints included changes in noninvasive serologic tests including APRI, fibrosis-4 index, NAFLD fibrosis score, enhanced liver fibrosis (ELF) and FibroTest (FibroSure in the USA).

Results
Forty-five randomized controlled trials enrolling 6932 patients were identified for this network meta-analysis. Across the primary endpoint, firsocostat, semaglutide, montelukast, cilofexor plus firsocostat, obeticholic acid and diacerein (change in LSM via vibration controlled transient elastography), in addition to lubiprostone and pemafibrate (change in LSM via magnetic resonance elastography) were found to be the most effective and statistically significant treatment interventions. Similarly, the following interventions were determined to be most effective as compared to placebo among secondary endpoints: saroglitazar, lubiprostone, and obeticholic acid (change in APRI); saroglitazar, semaglutide, firsocostat and cilofexor plus firsocostat (change in ELF); obeticholic acid and belapectin [change in FibroTest/FibroSure].

Conclusion
This is the first systematic review and network meta-analysis reporting pharmacologic efficacy in the progression of fibrosis based on noninvasive testing among patients with NAFLD. Semaglutide, obeticholic acid, firsocostat, cilofexor plus firsocostat and lubiprostone were found to be the most effective treatments based on their consistent efficacy reproduced across multiple endpoints, both via elastography and noninvasive blood tests.
DQA1*0102 DQB1*0602 haplotype distinguishes coeliac disease and its complications from gluten unrelated enteropathies
Authors: De Silvestri Annalisa , Schiepatti Annalisa , Fowler Bryce D , Badulli Carla , Belvisi Fabrizio , Cacciatore Rosalia , Pasi Annamaria , Zingone Fabiana , Goodwin John , Key Tim , Rej Anupam , Sanders David S , Biagi Federico 
Published: December 2022

Background
Duodenal villous atrophy is due not only to coeliac disease and its complications but also to other rare enteropathies unrelated to gluten consumption, defined as noncoeliac enteropathies. The diagnosis of noncoeliac enteropathies remains challenging, and HLA typing has been widely used to exclude coeliac disease if DQ2 and DQ8 alleles are absent. However, the frequency of the various HLA alleles in noncoeliac enteropathies is still unknown.

Aims
To describe the HLA genetic profile of patients affected by noncoeliac enteropathies who have been evaluated at our centres between 2000 and 2021, and to investigate the diagnostic role of HLA typing.

Methods
Genomic DNA was collected from 44 Italian and 19 British adult patients with noncoeliac enteropathies. Patient genotypes were compared with those of healthy Italian and British populations obtained from HLA bone marrow donors’ banks. In addition, genotypes were also compared with those of patients with coeliac disease and complicated coeliac disease.

Results
Both in the Italian and in the British group, the DQA1*0102 DQB1*0602 haplotype and related alleles occurred significantly more frequently in patients with noncoeliac enteropathies compared to coeliac disease and complicated coeliac disease.

Conclusions
Together with negative HLA-DQ2 and DQ8 haplotypes, the DQA1*0102 DQB1*0602 haplotype can be used to guide the differential diagnosis between coeliac disease and noncoeliac enteropathies.
68Ga-DOTATATE PET/CT of ACTH-Independent Cushing Syndrome Due to Ectopic Adrenocortical Adenoma
Authors: Jiang Yuanyuan , Liu Qingxing , Zhu Zhaohui 
Published: December 2022

Abstract
Adrenocorticotropic hormone–independent Cushing syndrome due to ectopic adrenocortical adenoma is a very rare entity. We herein present a case of a 57-year-old woman who was referred to our hospital with persistent Cushing syndrome after undergoing unnecessary laparoscopic left adrenalectomy. 68Ga-DOTATATE PET/CT revealed increased uptake in the nodule in the right hilum, which was histologically confirmed to be ectopic adrenocortical adenoma. Removal of the tumor was followed by the disappearance of clinical symptoms of Cushing syndrome. In this case, 68Ga-DOTATATE PET/CT contributed to the diagnosis of ectopic adrenocortical adenoma.
99mTc-Pyrophosphate Scintigraphy Can Image Tracer Uptake in Skeletal Trunk Muscles of Transthyretin Cardiac Amyloidosis
Authors: Takahashi Koji , Hiratsuka Yoshiyasu , Sasaki Daisuke , Sakaue Tomoki , Enomoto Daijiro , Morioka Hiroe , Uemura Shigeki , Okura Takafumi , Ikeda Shuntaro , Kono Taizo , Iwamura Takaaki , Yamamura Nobuhisa , Kitazawa Sohei , Ueda Mitsuharu 
Published: December 2022

Purpose

99mTc-pyrophosphate (99mTc-PYP) uptake in the skeletal muscles is minimal in patients with transthyretin cardiac amyloidosis (ATTR-CA) when assessed qualitatively and quantitatively. We previously demonstrated moderate- to high-grade 99mTc-PYP uptake in the subcutaneous abdominal fat of some patients with ATTR-CA and showed that this abnormal finding could reflect the regional amyloid burden of this tissue. We aimed to investigate the frequency of 99mTc-PYP uptake in skeletal trunk muscles of patients with ATTR-CA.

Methods
Chest- and abdomen-centered 99mTc-PYP scintigraphy images were obtained 2 hours after IV injections of the tracer (20 mCi) in 36 patients with ATTR-CA. The frequency of 99mTc-PYP uptake in the following 11 skeletal trunk muscles was investigated: pectoralis major, deltoid, subscapularis, infraspinatus, trapezius, latissimus dorsi, erector spinae, psoas major, abdominal oblique, rectus abdominis, and the gluteus muscles.

Results
Ten of the 11 muscles were involved in patients with the highest number of 99mTc-PYP uptake in the skeletal trunk muscles examined, whereas no muscle was involved in a patient with the least uptake. The muscle with the highest rate of 99mTc-PYP uptake, observed in 34 of 36 patients (94.4%), was the abdominal oblique. No tracer uptake was observed in the psoas major. The frequency of radiotracer uptake in the remaining examined muscles was between those of abdominal oblique and psoas major muscles.

Conclusions
Radiotracer uptake was often detectable in some skeletal trunk muscles of ATTR-CA, although the muscles of patients examined and the skeletal trunk muscles of 1 patient showed heterogeneity in the uptake of 99mTc-PYP.
Process of Hard Palate Osteonecrosis Demonstrated on Serial 18F-FDG PET/CT Scans
Authors: Song Le , Li Hui , Zhang Weifang 
Published: December 2022

Abstract
Osteonecrosis of the hard palate is rare. Here, we demonstrated the dynamic metabolic and structural changes during the process of osteonecrosis of the hard palate by serial 18F-FDG PET/CT scans in a patient with nasal NK/T-cell lymphoma. On the baseline scan, increased FDG uptake in the periphery of the hard palate could be observed. On the following scans after treatment, a focal metabolic defect on the hard palate with no structural changes and with bone sequestration and perforation have been observed successively. Our case indicates that the metabolic defect on 18F-FDG PET/CT may be an early sign of osteonecrosis.
Epidermal Cyst Mimicking Thyroid Cancer Metastasis
Authors: Luo Lingling , Xia Junyong , Bian Qianyu , Xiao Linlin , Yao Xiaobo 
Published: December 2022

Abstract
A 26-year-old woman with pulmonary metastasis of thyroid cancer underwent a total thyroidectomy and cervical lymph node dissection followed by 2 courses of 131I therapy. The posttherapeutic whole-body scan after the second dose of 131I therapy showed diffuse tracer uptake in both lungs. Besides this, there is a local abnormal radiotracer uptake in the left axillary region. SPECT/CT images localized this abnormal radioactivity in a subcutaneous, oval-shaped, approximately 2.2-cm slightly hyperdense lesion, which was pathologically confirmed as an epidermal cyst.
68Ga-FAPI PET/CT in a Patient With Statin-Induced Rhabdomyolysis
Authors: Liu Ya , Guo Chunmei , Chen Liming , Huang Zhanwen 
Published: December 2022

Abstract
Rhabdomyolysis is a syndrome characterized by muscle necrosis and the release of muscle cell contents into blood circulation. There is ample clinical evidence that it is one of the adverse effects of statins. 68Ga-FAPI PET/CT was performed on a 78-year-old man with newly diagnosed with mediastinal tumor and statin-induced rhabdomyolysis. 68Ga-FAPI PET/CT showed symmetrical and diffuse increased FAPI uptake in whole-body muscles. Our case indicated that 68Ga-FAPI PET/CT might be valuable in the evaluation of patients with rhabdomyolysis.
Histological Validation of FDG and PSMA-Targeted PET/CT Imaging in a Rare Tracheal Adenoid Cystic Carcinoma
Authors: Sandach Patrick , Seifert Robert , Slama Alexis , Theegarten Dirk , Hautzel Hubertus 
Published: December 2022

Abstract
Adenoid cystic carcinomas are the second most common entity of tracheal malignancies, which have an overall incidence as low as only 0.2 in 100,000 persons per year. We present the case of a 64-year-old man with a histologically confirmed adenoid cystic carcinoma who sequentially underwent 18F-FDG PET/CT and 68Ga-PSMA-11 PET/CT within 1 day for staging 3 days before surgical resection of the tumor. Immunohistochemistry revealed PSMA expression of the tumor corroborating the PSMA PET findings.
18F-FDG PET/CT in Primary Mesothelioma of the Liver
Authors: Pernthaler Birgit , Brcic Luka , Aigner Reingard Maria , Fuchsjäger Michael , Talakic Emina 
Published: December 2022

Abstract
Primary malignant mesothelioma is a rarity among malignant liver tumors. We present the case of a 48-year-old woman presenting with increasing upper abdominal discomfort and inappetence accompanied by a weight loss of approximately 10 kg. CT and MRI revealed a highly suspicious mass lesion in the liver. 18F-FDG PET/CT performed for staging showed a pathological 18F-FDG uptake of the known liver tumor. Histology and immunohistochemistry indicated mesothelioma of the liver. Herein we present a rare case of primary mesothelioma in the liver with CT, MRI, and 18F-FDG PET/CT.
First Report With Medium-term Follow-up of Intestinal Transplantation for Advanced and Recurrent Nonresectable Pseudomyxoma Peritonei
Authors: Reddy Srikanth , Punjala Sai Rithin , Allan Philip , Vaidya Anil , Borle Deeplaxmi P. , Geiele Henk , Udupa Venkatesha , Smith Alison , Vokes Lisa , Vrakas Georgios , Mohamed Faheez , Dayal Sanjeev , Moran Brendan , Friend Peter J. , Cecil Tom 
Published: December 2022

Objective:
To report our experience with the combination of radical surgical excision and intestinal transplantation in patients with recurrent pseudomyxoma peritonei (PMP) not amenable to further cytoreductive surgery (CRS).

Background:
CRS and heated intraoperative peritoneal chemotherapy are effective treatments for many patients with PMP. In patients with extensive small bowel involvement or nonresectable recurrence, disease progression results in small bowel obstruction, nutritional failure, and fistulation, with resulting abdominal wall failure.

Methods:
Between 2013 and 2022, patients with PMP who had a nutritional failure and were not suitable for further CRS underwent radical debulking and intestinal transplantation at our centre.

Results:
Fifteen patients underwent radical exenteration of affected intra-abdominal organs and transplantation adapted according to the individual case. Eight patients had isolated small bowel transplantation and 7 patients underwent modified multivisceral transplantation. In addition, in 7 patients with significant abdominal wall tumor involvement, a full-thickness vascularized abdominal wall transplant was performed. Two of the 15 patients died within 90 days due to surgically related complications. Actuarial 1-year and 5-year patient survivals were 79% and 55%, respectively. The majority of the patients had significant improvement in quality of life after transplantation. Progression/recurrence of disease was detected in 91% of patients followed up for more than 6 months.

Conclusion:
Intestinal/multivisceral transplantation enables a more radical approach to the management of PMP than can be achieved with conventional surgical methods and is suitable for patients for whom there is no conventional surgical option. This complex surgical intervention requires the combined skills of both peritoneal malignancy and transplant teams.
Actinomyces and Shewanella algae complicated paediatric mastoiditis: a case report of a multidisciplinary approach
Authors: Martins Sousa Mafalda , von Hafe Madalena , Reis-Melo Ana , Silveira Helena , Coutinho Gil , Moura Carla Pinto 
Published: December 2022

Cerebral venous sinus thrombosis in children is a rare complication of acute mastoiditis that can potentially be fatal. Clinical expertise is essential for early diagnosis and management due to its subtle course. We present the first known case of paediatric acute mastoiditis with venous sinus thrombosis caused by

Shewanella algae

and

Actinomyces europaeus

.
A 17-year-old male presented clinical signs of right acute otitis media and mastoiditis. Brain computed tomography showed mastoid opacification, cerebral sinus thrombosis and an extradural collection. Microbiology revealed the presence of

S. algae

and

A. europaeus

. A multidisciplinary approach combining medical and surgical treatment allowed the patient to make a full recovery.
The combination of aggressive hydration and rectal non-steroidal anti-inflammatory drugs is not superior to rectal non-steroidal anti-inflammatory drugs alone in the prevention of pancreatitis after endoscopic retrograde cholangiopancreatography: a systematic review and meta-analysis
Authors: Cheng Xiang , Yang Feixiang , Yang Xingxin , Zhang Ning , Li Xiaoming , Chen Bo 
Published: December 2022

AbstractBackgroundendoscopic retrograde cholangiopancreatography (ERCP) can lead to many high-risk complications, of which acute pancreatitis is the most prevalent and serious one. Whether patients who receive prophylactic rectal non-steroidal anti-inflammatory drugs (NSAIDs) need to be combined with aggressive hydration remains controversial.AimThe study was performed to determine whether there is collaborative facilitation between rectal NSAIDs and aggressive hydration in preventing post-ERCP pancreatitis (PEP).MethodsWe searched all eligible studies on the preventive effects of active rehydration and NSAIDs on PEP from multiple databases including ClinicalTrials, PubMed, CQVIP, Embase, Web of Science, CNKI, Cochrane Library, and Wanfang Data. We performed a meta-analysis of the data related to the incidence of PEP as well as the serious cases including the incidence of severe PEP and mortality.ResultsThis meta-analysis included three published studies of randomized controlled trials with 1110 patients. Our results showed that additional aggressive hydration was not significantly effective for the prevention of PEP in patients who were already receiving rectal NSAIDs (odds ratio [OR], 0.43; 95% confidence interval [CI], 0.12-1.57; P=0.20). With regard to the prevention of serious cases, compared with rectal NSAIDs alone, aggressive fluid hydration combined with rectal NSAIDs did not reduce the morbidity of severe PEP (OR, 0.32; 95% CI, 0.10-1.08; P=0.07), nor did it reduce overall mortality (OR, 0.81; 95% CI, 0.28-2.36; P=0.70).ConclusionAggressive perioperative hydration combined with rectal NSAIDs was not superior to rectal NSAIDs along in the prevention of PEP.
Biosynthesis of pleuromutilin congeners using anAspergillus oryzaeexpression platform
Authors: Alberti Fabrizio , Khairudin Khairunisa , Davies Jonathan A. , Sangmalee Suphattra , Willis Christine L. , Foster Gary D. , Bailey Andy M. 
Published: December 2022

AbstractPleuromutilin is an antibiotic diterpenoid made byClitopilus passeckerianusand related fungi, and it is the progenitor of a growing class of semi-synthetic antibiotics used in veterinary and human medicine. To harness the biotechnological potential of this natural product class, a full understanding of its biosynthetic pathway is essential. Previously, a linear pathway for pleuromutilin biosynthesis was established. Here we report two shunt pathways involving Pl-sdr and Pl-atf that were identified through the rational heterologous expression of combinations of pleuromutilin biosynthetic genes inAspergillus oryzae. Three novel pleuromutilin congeners were isolated, and their antimicrobial activity was investigated, alongside that of an additional derivative produced through a semi-synthetic approach. It was observed that the absence of substituents – C-3 keto, C-11 hydroxy or C-21 keto – from the pleuromutilin core affected the antibacterial activity of pleuromutilin congeners. This study expands our knowledge on the biosynthesis of pleuromutilin and provides avenues for the development of novel pleuromutilin analogues by combining synthetic biology and synthetic chemistry.