bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical implications of PON1 (rs662) and TNF-α (rs1799964) genes polymorphism in patients with coronary artery disease
Authors: Raza Syed Tasleem , Abbas Shania , Wani Irshad Ahmad , Eba Ale , Mahdi Farzana 
Published: July 2022

Abstract
Background
Coronary artery disease (CAD) is the most common kind of heart problem, currently became one of the leading causes of death worldwide and is predicted to persist so for the next 20 years. The global risk factors to CAD include atherosclerosis, genetic predisposition, environment and the lifestyle. This study is aimed to find out the genotypic association of PON1 (rs662) and TNF-α (rs1799964) genes with CAD among North Indian populations. A total of 330 subjects including 175 CAD cases and 155 healthy controls were enrolled in this study. Single nucleotide polymorphisms were analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR–RFLP) method. χ2 and Student's t-tests were applied for the comparison of alleles and genotype frequencies in cases and controls. Logistic regression analysis was applied to calculate the 95% confidence intervals and odds ratios (OR) for assessing the association of genotype with disease.

Results
The PON1 gene QQ, QR, RR genotypes frequencies were 36.57%, 50.29%, 13.14% in CAD cases and 60%, 38.71%, 1.29% in controls, respectively. OR for the genotype QQ, QR, RR was 0.38, 1.6, 11.57 (P < 0.001, P = 0.035, P < 0.001). The TNF-α gene CC, CT, TT genotypes frequencies in cases were 4.57%, 50.29%, 45.14% and controls 3.23%, 46.45%, 50.32%, respectively. OR for CC, CT, TT genotype was 1.437, 1.166, 0.812 (P = 0.531, P = 0.487, P = 0.347). We found significant difference in the genotype and allele frequencies of PON1 gene between cases and control, while no significant difference was observed in TNF-α gene between cases and control.

Conclusions
The PON1 (rs662) gene polymorphisms were significantly associated with an elevated risk of CAD, while no significant association was observed with TNF-α (rs1799964) gene polymorphism and the risk of CAD.
Investigation of the relationship between perceived social support and body image in women with breast cancer
Authors: Doori Zahra , Hekmat Khadijeh , Mousavi Parvaneh , Latifi Seyed Mahmood , Shahbazian Hojatollah 
Published: July 2022

Abstract
Background
Patients with breast cancer have more body image disorders than healthy individuals. The present study aimed to determine the relationship between perceived social support and body image in women with breast cancer. This descriptive-analytical study was performed on 192 women with breast cancer undergoing mastectomy or tumor resection with breast preservation referred to Golestan Hospital in Ahvaz from February 2016 to May 2017. Data collection tools included Demographic Information, Perceived Social Support, and Multidimensional Body-Self Relationship Questionnaires (MBSRQ). Data analysis was performed using SPSS 22 and Pearson correlation coefficient and multivariate linear regression. A p value less than 0.05 was considered significant.

Results
The Pearson correlation test showed a positive and significant relationship between perceived social support from family, friends, and leading people and body image in mastectomy (r 0.81) and tumor resection groups with breast preservation (r 0.78) (p < 0.001).

Conclusion
The results showed a direct relationship between perceived social support and body image in women with breast cancer. Accordingly, by educating patients and their families and medical staff about the importance of perceived social support, it is possible to help improve the dimensions of social support in these patients and improve the body image of these patients.
Symmetry and financial markets
Authors: Andersen Jorgen Vitting , Nowak Andrzej 
Published: July 2022

Abstract
It is hard to overstate the importance that the concept of symmetry has had in every field of physics, a fact alluded to by the Nobel Prize winner P.W. Anderson, who once wrote that “physics is the study of symmetry”. Whereas the idea of symmetry is widely used in science in general, very few (if not almost no) applications has found its way into the field of finance. Still, the phenomenon appears relevant in terms of for example the symmetry of strategies that can happen in the decision making to buy or sell financial shares. Game theory is therefore one obvious avenue where to look for symmetry, but as will be shown, also technical analysis and long term economic growth could be phenomena which show the hallmark of a symmetry.
The potential utility of an augmented data collection approach in understanding the journey to care of pregnant women for maternal and perinatal death surveillance and response
Authors: Banke-Thomas Aduragbemi 
Published: July 2022

Background: The Maternal and Perinatal Death Surveillance and Response (MPDSR) proposed by the World Health Organization recognises the importance for health systems to understand the reasons underpinning the death of a pregnant woman or her newborn as an essential first step in preventing future similar deaths. Data for the surveillance component of the MPDSR process are typically collected from health facility sources and post-mortem interviews with affected families, though it may be traumatising to them. This brief report aimed to assess the potential utility of an augmented data collection method for mapping journeys of maternal and perinatal deaths, which does not require sourcing additional information from grieving family members. Methods: A descriptive analysis of maternal and perinatal deaths that occurred across all 24 public hospitals in Lagos State, Nigeria, between 1st November 2018 and 30th October 2019 was conducted. Data on their demographic, obstetric history and complication at presentation, travel to the hospital, and mode of birth were extracted from their hospital records. The extracted travel data was exported to Google Maps, where driving distance and travel time to the hospital for the period of the day of travel were also extracted. Results: Of the 182 maternal deaths, most presented during the week (80.8%), travelled 5-10 km (30.6%) and 10-29 minutes (46.9%), and travelled to the nearest hospital to their places of residence (70.9%). Of the 442 pregnant women who had perinatal deaths, most presented during the week (78.5%), travelled <5 km (26.9%) and 10-29 minutes (38.0%). For both, the least reported travel data was the mode of travel used to care (>90.0%) and the period of the day they travelled (approximately 30.0%). Conclusion: An augmented data collection approach that includes accurate and complete travel data and closer-to-reality estimates of travel time and distance can be beneficial for MPDSR purposes.
Impact of a postgraduate year one (PGY-1) otolaryngology bootcamp on procedural skill development
Authors: Wajsberg Benjamin , Li Daniel , Kohanzadeh Avraham , Bitners Anna C. , Gorthey Scott , Gibber Marc J. , Rong Esther , Bent John P. , Gangar Mona , Yang Christina J. 
Published: July 2022

Background: To measure the impact of an intensive eight-week postgraduate year one (PGY-1) otolaryngology bootcamp on the acquisition and retention of otolaryngology residents’ procedural skills compared to the traditional method of skill acquisition through clinical exposure. Methods: Residents at our institution were evaluated on their performance of flexible laryngoscopy, suture ligature, and rigid bronchoscopy setup at three time points: pre-bootcamp, one-week post-bootcamp, and one-year post-bootcamp. Video recordings were scored by two blinded faculty reviewers using a multipoint rating system. A control group of rising postgraduate year two (PGY-2) residents who did not participate in bootcamp were recorded performing these same skills. Scores in the three skills were compared between groups via t-tests. The eight-week bootcamp curriculum for PGY-1s was held at the Montefiore Einstein Center for Innovation in Simulation at Albert Einstein College of Medicine/Montefiore Medical Center. The participants were two classes of PGY-1 residents (n=8) at our institution who participated in a bootcamp at the beginning of residency, and one class of rising PGY-2 residents (n=3) who did not participate in a bootcamp (control group). Results: A comparison of pre-bootcamp scores to one-week post-bootcamp scores showed significant improvement in suture ligature (P<0.05) and rigid bronchoscopy (P<0.05), but no difference in flexible laryngoscopy (P=0.54). Suture ligature (P=0.09) and rigid bronchoscopy (P=0.25) skills were not significantly different from one-week post-bootcamp to one-year post-bootcamp; however, a significant skill improvement was observed in flexible laryngoscopy (P<0.05). By June of PGY1 year, the two bootcamp cohorts were similar to controls in all three skills: flexible laryngoscopy (P=0.05), rigid bronchoscopy (P=0.26), and suture ligature (P=0.10). Conclusions: Participation in PGY-1 bootcamp was associated with improved acquisition and short-term retention of basic procedural skills, suggesting that bootcamps can be an effective arena to teach basic skills in otolaryngology. PGY-1 bootcamp is a promising arena for multi-institutional development.
Evolução dos cadastros individuais no SISAB a partir do novo financiamento da atenção básica: Um estudo descritivo
Authors: Lopes Síntique Priscila Alves , Araujo Juliana de Sousa , Figueiredo Laís Gomes Martins , Almeida Michele Alcântara de , Araújo Bianca Lís Souza , Moreira Marcela Beatriz Aguiar , Cangussu Maria Cristina Teixeira Cangussu 
Published: July 2022

Introdução: Compreende-se que o novo financiamento da Atenção Básica através do Previne Brasil instituído em novembro de 2019, implicou na necessidade de cadastros individuais como premissa para repasse de recursos aos municípios. Objetivo: Este estudo pretende evidenciar a evolução do número de cadastros individuais entre os estados do Nordeste no período entre o terceiro quadrimestre de 2019 (2019Q3) e o terceiro quadrimestre de 2020 (2020Q3). Materiais e métodos: Trata-se de um estudo transversal descritivo de natureza quantitativa pautado em dados secundários coletados do Sistema de Informação da Atenção Básica (SISAB) entre fevereiro e março de 2021. Resultados: A Bahia apresentou maior evolução no número de cadastros com percentual equivalente a 7,12% enquanto o Ceará não apresentou crescimento no número de cadastros. Os outros estados que compõem a região Nordeste, não apresentaram variação crescente superior a 4%. Conclusão: Em um ano de implantação do Programa, observou-se que a evolução dos cadastros ainda é incipiente, sendo necessárias novas investigações junto aos municípios a fim de serem levantadas estratégias para incremento dos cadastros individuais e por conseguinte manutenção do custeio da Atenção Primária à Saúde.
The third-generation biodiesel blends corrosion susceptibility of oxide particle-reinforced Si-rich aluminum alloy matrix composites
Authors: Hosseinabadi Navid , Moheimani Navid R. 
Published: July 2022

Abstract
The study of a stir cast Al356-Nb2O5)P composite immersed in third-generation microalgal-derived biodiesel blends with enhanced plasma electrolyte oxidation surface modification revealed the corrosion susceptibility and possible by-product formation. The effect of (oxide)P reinforcement and mixed-oxide surface coatings were studied separately and cumulatively. Samples were immersed in different biodiesel and petrodiesel blends for up to 3000 h, and their corrosion and electrochemical behavior was studied. Although some weight change was recorded in all samples, the corrosion rates significantly decreased from 1.8 to 1.3 by 10 wt% Nb2O5)P reinforcement, which further decreased 10 times after surface modification. Electron microscopy revealed primary fine-grained microstructure with low porosity content of fine and needlelike dendritic structures in composites and irregular volcanic with scattered micropores and microcracks in surface-modified composites that changed to corrosion spots and flake-covered microcracks after immersion.
Graphene-based coatings for magnesium alloys: exploring the correlation between coating architecture, deposition methods, corrosion resistance and materials selection
Authors: Lopes de Oliveira Mara Cristina , Antunes Renato Altobelli 
Published: July 2022

Abstract
Graphene and its derivatives have attracted much interest as corrosion-resistant coatings for magnesium alloys since 2014, when the first reports appeared in the literature. The interest in the use of such carbonaceous compounds to protect magnesium and its alloys from corrosion relies on a set of attributes such as chemical inertness, and high surface area. To support the development of optimized graphene-based films it is imperative to expand the current knowledge toward a deeper understanding of corrosion mechanisms and their interaction with practical aspects related to coating deposition and morphology. In the present work, graphene-based coatings for magnesium alloys are reviewed. We explored the correlation between coating architecture, deposition methods and materials selection using the Ashby approach. The results of the materials selection process revealed that composite coatings consisting of an inorganic matrix obtained by plasma electrolytic oxidation of magnesium alloys and graphene oxide nanosheets as blocking agents can provide surfaces with high corrosion resistance in sodium chloride solution. For biomedical applications, composite coatings consisting of a mixture of organic matrices such as chitosan and graphene oxide as reinforcing particles are attractive candidates. The results are discussed based on coating architecture and its interplay with the corrosion properties.
Status of liquid profiling in precision oncology – the need for integrative diagnostics for successful implementation into standard care
Authors: Froelich Matthias F. , Schoenberg Stefan O. , Neumaier Michael , Haselmann Verena 
Published: July 2022

Abstract
The liquid profiling approach is currently at the threshold of translation from research application in various clinical trials to introduction into the management of cancer patients in the context of clinical care. Routine application has focused primarily on the analysis of single blood-based biomarkers for companion diagnostics. However, liquid profiling promises much broader diagnostic potential, which is discussed and illustrated in this manuscript through several case reports. These clinical cases range from identification of druggable targets to the detection of subclonal resistance mechanisms. In addition, liquid profiling can be used in clinical practice to identify complex molecular patterns or as a personalized tumor marker for patient-specific monitoring of response to treatment. These examples highlight both the value and limitations of liquid profiling in various clinical settings, which could be overcome by an integrative diagnostic approach with imaging techniques. The complementary advantages of both diagnostics approaches will allow combining high sensitivity with genetic tumor profiling and topologic assignment. Therefore, we advocate interdisciplinary integrated collaboration between laboratory and imaging experts to unravel the potentials of precision diagnostics in cancer care.
Liquid profiling for cancer patient stratification in precision medicine – current status and challenges for successful implementation in standard care
Authors: Haselmann Verena , Hedtke Maren , Neumaier Michael 
Published: July 2022

Abstract
Circulating tumor DNA (ctDNA), accurately described by the term liquid profiling (LP), enables real-time assessment of the tumor mutational profile as a minimally invasive test and has therefore rapidly gained traction, particular for the management of cancer patients. By LP, tumor-specific genetic alterations can be determined as part of companion diagnostics to guide selection of appropriate targeted therapeutics. Because LP facilitates longitudinal monitoring of cancer patients, it can be used to detect acquired resistant mechanisms or as a personalized biomarker for earlier detection of disease recurrence, among other applications. However, LP is not yet integrated into routine care to the extent that might be expected. This is due to the lack of harmonization and standardization of preanalytical and analytical workflows, the lack of proper quality controls, limited evidence of its clinical utility, heterogenous study results, the uncertainty of clinicians regarding the value and appropriate indications for LP and its interpretation, and finally, the lack of reimbursement for most LP tests. In this review, the value proposition of LP for cancer patient management and treatment optimization, the current status of implementation in standard care, and the main challenges that need to be overcome are discussed in detail.
Metonymy in the Korean internally headed relative clause construction
Authors: Park Chongwon 
Published: July 2022

Abstract
This article aims to analyze the Korean internally headed relative clause (IHRC) construction from a Cognitive Grammar perspective. The primary issue concerning the Korean IHRC construction is the mismatch between the syntactic object and the semantic head. While the whole embedded clause headed by kes functions as a grammatical object, the semantic head may acquire the object status. I demonstrate that the mismatch is nothing but a metonymic process, just like the mismatch we observe in the loon in the water; even when only the loon’s feet are in the water, the expression is felicitously understood without identifying the particular portion of the loon under water. Just like the speaker accesses the loon’s feet through the loon, she accesses the semantic head through the reified embedded clause in the IHRC construction. I show that adopting this general human cognitive process helps us reach a broader generalization and sheds new light on hitherto neglected examples.
BaFe0.875Re0.125O3−δ
and BaFe0.75Ta0.25O3−δ
as potential cathodes for solid-oxide fuel-cells: a structural study from neutron diffraction data
Authors: García-Ramos Crisanto , Cascos Vanessa , Prado-Gonjal Jesús , Schmidt Rainer , Fernández-Díaz María Teresa , Krezhov Kiril , Alonso José Antonio 
Published: July 2022

Abstract
In this work, two new perovskites of composition BaFe0.875Re0.125O3−δ
and BaFe0.75Ta0.25O3−δ
, designed from ab-initio calculations to fulfill different requisites of cathode materials for solid-oxide fuel cells (SOFC), were prepared and studied from the structural point of view from neutron powder diffraction (NPD) data. They are both derivatives of BaFeO3 hexagonal perovskite (space group P6

3
/mmc), typified as the 6H polytype, stabilized when the perovskite tolerance factor slightly overpasses the unity. Whereas BaFe0.875Re0.125O3−δ
keeps this structural type, as demonstrated in this crystallographic study from NPD data at 295 and 4 K, with unit-cell parameters a = 5.70177(7); c = 14.0334(2) Å at 295 K, the second material, BaFe0.75Ta0.25O3−δ
, is cubic and can be defined in the Pm-3m space group, corresponding of the perovskite arystotype, with a = 4.05876(3) Å. A conspicuous oxygen deficiency is observed, with a refined stoichiometry of 2.86(3) per formula unit. The anisotropic displacement factors for oxygen atoms in this last material are flattened disks perpendicular to the (Fe,Ta)-O-(Fe,Ta) direction, suggesting a dynamic tilting of the octahedra that could be related to the oxygen motion via oxygen vacancies across the structure. This is a pre-requisite for functional mixed-ionic-electronic (MIEC) materials performing as cathodes in SOFC.
Sex Differences in the Alcohol-Mediated Modulation of BLA Network States
Authors: DiLeo Alyssa , Antonoudiou Pantelis , Ha Spencer , Maguire Jamie L. 
Published: July 2022

AbstractAlcohol use, reported by 85% of adults in the United States, is highly comorbid with mood disorders, like generalized anxiety disorder and major depression. The basolateral amygdala (BLA) is an area of the brain that is heavily implicated in both mood disorders and alcohol use disorder. Importantly, the modulation of BLA network/oscillatory states via parvalbumin (PV)-positive GABAergic interneurons has been shown to control the behavioral expression of fear and anxiety. Further, PV interneurons express a high density of δ subunit-containing GABAAreceptors (GABAARs), which are sensitive to low concentrations of alcohol. Therefore, we hypothesized that the effects of alcohol may modulate BLA network states that have been associated with fear and anxiety behaviors via δ-GABAARs on PV interneurons in the BLA. Given the impact of ovarian hormones on the expression of δ-GABAARs, we also examined the ability of alcohol to modulate local field potentials in the BLA from male and female C57BL/6J andGabrd−/−mice after acute and repeated exposure to alcohol. Here, we demonstrate that acute and repeated alcohol can differentially modulate oscillatory states in male and female C57BL/6J mice, a process that involves δ-GABAARs. This is the first study to demonstrate that alcohol is capable of altering network states implicated in both anxiety and alcohol use disorders.
PLCβ-Mediated Depletion of PIP2and ATP-Sensitive K+Channels Are Involved in Arginine Vasopressin-Induced Facilitation of Neuronal Excitability and LTP in the Dentate Gyrus
Authors: Lei Saobo , Boyle Cody A. , Mastrud Morgan 
Published: July 2022

AbstractArginine vasopressin (AVP) serves as a neuromodulator in the brain. The hippocampus is one of the major targets for AVP, as it has been demonstrated that the hippocampus receives vasopressinergic innervation and expresses AVP receptors. The dentate gyrus (DG) granule cells (GCs) serve as a gate governing the inflow of information to the hippocampus. High densities of AVP receptors are expressed in the DG GCs. However, the roles and the underlying cellular and molecular mechanisms of AVP in the DG GCs have not been determined. We addressed this question by recording from the DG GCs in rat hippocampal slices. Our results showed that application of AVP concentration-dependently evoked an inward holding current recorded from the DG GCs. AVP depolarized the DG GCs and increased their action potential firing frequency. The excitatory effects of AVP were mediated by activation of V1areceptors and required the function of phospholipase Cβ (PLCβ). Whereas intracellular Ca2+release and protein kinase C activity were unnecessary, PLCβ-induced depletion of phosphatidylinositol 4,5-bisphosphate was involved in AVP-evoked excitation of the DG GCs. AVP excited the DG GCs by depression of the ATP-sensitive K+channels, which were required for AVP-elicited facilitation of long-term potentiation at the perforant path–GC synapses. Our results may provide a cellular and molecular mechanism to explain the physiological functions of AVP, such as learning and memory, and pathologic disorders like anxiety.