bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automatic Ferroelectric Domain Pattern Recognition Based on the Analysis of Localized Nonlinear Optical Responses Assisted by Machine Learning
Authors: Croes Boris , Gaponenko Iaroslav , Voulot Cédric , Grégut Olivier , Dorkenoo Kokou D. , Cheynis Fabien , Curiotto Stefano , Müller Pierre , Leroy Frédéric , Cordero‐Edwards Kumara , Paruch Patrycja , Cherifi‐Hertel Salia 
Published: December 2022

AbstractSecond‐harmonic generation (SHG) is a nonlinear optical method allowing the study of the local structure, symmetry, and ferroic order in noncentrosymmetric materials such as ferroelectrics. The combination of SHG microscopy with local polarization analysis is particularly efficient for deriving the local polarization orientation. This, however, entails the use of tedious and time‐consuming modeling methods of nonlinear optical emission. Moreover, extracting the complex domain structures often observed in thin films requires a pixel‐by‐pixel analysis and the fitting of numerous polar plots to ascribe a polarization angle to each pixel. Here, the domain structure of GeTe films is studied using SHG polarimetry assisted by machine learning. The method is applied to two film thicknesses: A thick film containing large domains visible in SHG images, and a thin film in which the domains' size is below the SHG resolution limit. Machine learning‐assisted methods show that both samples exhibit four domain variants of the same type. This result is confirmed in the case of the thick film, both by the manual pixel‐by‐pixel analysis and by using piezoresponse force microscopy. The proposed approach foreshows new prospects for optical studies by enabling enhanced sensitivity and high throughput analysis.
Analysis of maximum precipitation in Thailand using non‐stationary extreme value models
Authors: Prahadchai Thanawan , Shin Yonggwan , Busababodhin Piyapatr , Park Jeong‐Soo 
Published: December 2022

AbstractNon‐stationarity in heavy rainfall time series is often apparent in the form of trends because of long‐term climate changes. We have built non‐stationary (NS) models for annual maximum daily (AMP1) and 2‐day precipitation (AMP2) data observed between 1984 and 2020 years by 71 stations and between 1960 and 2020 by eight stations over Thailand. The generalized extreme value (GEV) models are used. Totally, 16 time‐dependent functions of the location and scale parameters of the GEV model are considered. On each station, a model is selected by using Bayesian and Akaike information criteria among these candidates. The return levels corresponding to some years are calculated and predicted for the future. The stations with the highest return levels are Trad, Samui, and Narathiwat, for both AMP1 and AMP2 data. We found some evidence of increasing (decreasing) trends in maximum precipitation for 22 (10) stations in Thailand, based on NS GEV models.
On the cosmological constant in the deformed Einstein–Cartan gauge gravity in De Donder–Weyl Hamiltonian formulation
Authors: Vasak David , Kirsch Johannes , Struckmeier Jürgen , Stöcker Horst 
Published: December 2022

AbstractA modification of the Einstein–Hilbert theory, the Covariant Canonical Gauge Gravity (CCGG), leads to a cosmological constant that represents the energy of the space–time continuum when deformed from its (A)dS ground state to a flat geometry. CCGG is based on the canonical transformation theory in the De Donder–Weyl (DW) Hamiltonian formulation. That framework modifies the Einstein–Hilbert Lagrangian of the free gravitational field by a quadratic Riemann–Cartan concomitant. The theory predicts a total energy‐momentum of the system of space–time and matter to vanish, in line with the conjecture of a “Zero‐Energy‐Universe” going back to Lorentz (1916) and Levi‐Civita (1917). Consequently, a flat geometry can only exist in presence of matter where the bulk vacuum energy of matter, regardless of its value, is eliminated by the vacuum energy of space–time. The observed cosmological constant Λobs is found to be merely a small correction attributable to deviations from a flat geometry and effects of complex dynamical geometry of space–time, namely torsion and possibly also vacuum fluctuations. That quadratic extension of General Relativity, anticipated already in 1918 by Einstein, thus provides a significant and natural contribution to resolving the “cosmological constant problem”.
Self‐reported cognitive decline among middle and older age autistic adults
Authors: Klein Claire B. , McQuaid Goldie A. , Charlton Rebecca A. , Klinger Laura G. , Wallace Gregory L. 
Published: December 2022

AbstractVery little is known about autistic adults as they age. Early evidence suggests a potentially high risk for dementia and atypical cognitive decline in autistic middle and older age adults. Research in the general population indicates that self‐reported cognitive decline may predict future dementia earlier than performance‐based measures. Nevertheless, self‐report dementia screeners have not been used to date in autism research. In a sample of middle and older age autistic adults (N = 210), participants completed a self‐rated dementia screener, the AD8, to describe the rate of cognitive decline, examine associations of cognitive decline with age, educational level, sex designated at birth, and autistic traits, and document the psychometrics of a dementia screener in autistic adults. We found high rates of cognitive decline with 30% of the sample screening positive. The most common symptoms were declining interest in leisure activities, and increases in everyday problems with thinking, memory, and judgment. There was evidence that autistic individuals designated female at birth may be more vulnerable to cognitive decline than autistic individuals designated male at birth. Notably, reports of cognitive decline did not vary by age or educational level. Modestly elevated autistic traits were found in those screening positive versus negative for cognitive decline. Finally, the dementia screener showed good psychometrics, including convergent validity with an independent measure of current memory problems. These results could signal an emerging public health crisis in autistic adults as they age, and support the potential utility of self‐report measures for early screening for cognitive decline in this population.
Development of na HPLC–MS/MS method for the determination of ginsenosides Rg1 and Rb1 from ‘Shenmai’ Injection in beagle dogs after single and multiple doses and application in pharmacokinetics
Authors: Wen Min , Yang Lipan , Huang Hefei , Ye Gu , Jiang Yuntao , Lv Xiaobo 
Published: December 2022

AbstractShenmai Injection (SMI), which tonifies Qi and prevents exhaustion, nourishes Yin and generates body fluid, is usually used in the treatment of shock with deficiency of Qi and Yin, coronary artery disease, viral myocarditis, granulocytopenia and chronic pulmonary heart disease clinically. Ginsenosides Rg1 and Rb1 are the main active ingredients of SMI. In this study, high‐performance liquid chromatography tandem mass spectrometry methods for quantification of Rb1 and Rg1 in beagle dogs were developed and validated according to international regulatory guidelines. The methods were applied to measure the pharmacokinetics parameters of the two ginsenoside after intravenous administration. The linear ranges of the analytes were 3.9–1,000 ng/ml for Rg1 and Rb1. After injection of single and multiple doses of SMI (1 ml/kg), the plasma concentration–time profiles of Rg1 and Rb1 met the characteristics of one‐compartment and typical two‐compartment intravenous injection.
A case of thoracic SMARCA4‐Deficient undifferentiated tumor successfully treated with combination Ipilimumab–Nivolumab
Authors: Nakano Yoshio , Sekinada Daisuke , Kuze Yusuke , Okamoto Norio , Gohma Iwao , Yasuhara Yumiko 
Published: December 2022

AbstractThoracic SMARCA4‐deficient undifferentiated tumors are rare, with poor prognosis. A 73‐year‐old man presented to our hospital with dyspnea. Computed tomography‐guided biopsy revealed a SMARCA4‐deficient undifferentiated tumor. The patient was treated with combination ipilimumab‐nivolumab. The tumor reduced in size after two courses.
A pH‐Responsive Charge‐Convertible Drug Delivery Nanocarrier for Precise Starvation and Chemo Synergistic Oncotherapy
Authors: Zhou Yifei , Gao Xuan , Lu Yu , Zhang Ruohao , Lv Kehong , Gong Jitong , Feng Jing , Zhang Hongjie 
Published: December 2022

AbstractA pH‐responsive charge‐convertible drug delivery nanocarrier (MSN‐TPZ‐GOx@ZnO@PAH‐PEG‐DMMA, abbreviated as MTGZ@PPD) was prepared, which could specifically release hypoxia‐activated chemotherapeutic Tirapazamine (TPZ) and glucose oxidase (GOx) in the tumor site for precise starvation and chemo synergistic oncotherapy. Acid‐responsive Schiff base structure modified mesoporous silica nanoparticles (MSN) co‐load with GOx and TPZ, then link with ZnO quantum dots (QDs). PAH‐PEG‐DMMA (PPD) polymer makes MTGZ@PPD with biocompatibility and charge‐convertible feature. MTGZ@PPD is negatively charged at physiological pH, and the charge reversal of PPD and acidolysis of the Schiff base structure under the acidic tumor microenvironment (TME) induce a positively charged surface, which could potentiate the cell internalization. ZnO QDs could decompose at acidic TME, achieving controllable drug release. GOx could starve the tumor cells and enhance hypoxia level, thus initiates the activation of TPZ to realize synergistic starvation therapy and chemotherapy. This intelligent MTGZ@PPD has shown great potential for starvation and chemo synergistic oncotherapy.
A level enhanced voltage balancing method for modular multilevel converter without using sensors
Authors: Gobburi Hari Babu , Borghate Vijay B. , Meshram Prafullachandra M. 
Published: December 2022

SummaryThe intrinsic characteristics such as modular structure, filterless operation, and absence of DC‐link capacitor have made the modular multilevel converter (MMC) superior to the conventional multilevel converters. However, the submodule (SM) capacitor voltage balancing is crucial. This paper presents a voltage balance control method for MMC. The proposed method generates 2N + 1 levels (where N is the number of SMs per arm) which halves the step size of output voltage and improves the harmonic performance as compared to N + 1 level generation. It requires only one carrier per phase and no voltage and current measurements are needed for the implementation. Therefore, the proposed method makes the system cost‐effective and reduces the implementation issues related with carrier‐based methods substantially. It also alleviates the non‐uniform charge distribution problem with the phase disposition pulse width modulation (PDPWM) technique. Further, a detailed mathematical analysis is presented which enhances the understanding of balancing algorithm. In addition to this, the circulating current with 2N + 1 modulation is analyzed and a control technique is presented. The proposed voltage balancing method is simulated comprehensively in MATLAB/SIMULINK software and validated by the experimental results obtained from a laboratory prototype.
Efficacy and safety of PD‐1 inhibitor alone or combined with chemotherapy in patients with relapsed or refractory extranodal natural Killer/T cell lymphoma: A retrospective study
Authors: Tian Jing , Hao Miaowang , Liu Qiang , Xiao Fang , Li Yuanchun , Qi Meiying , Gao Jing , Liu Li , Yin Dandan 
Published: December 2022

AbstractExtranodal natural killer/T cell lymphoma (ENKTL) patients typically face a grim prognosis after relapse or progression following asparaginase‐based chemotherapy. Currently, programmed cell death protein‐1 (PD‐1) immune checkpoint blockade has shown promising efficacy as an optimal regimen for relapsed or refractory ENKTL (rrENKTL) patients. This study retrospectively investigated the efficacy, safety, and factors influencing the survival of 26 rrENKTL patients who underwent monoclonal antibody treatment using PD‐1 (Sintilimab or Camrelizumab) alone or combined with chemotherapy from January 2018 to February 2022. The disease control rate was 73.1%, and the objective response rate was 50.0%. 15.4% of the patients achieved complete remission, and 34.6% achieved partial remission (PR). After a median follow‐up of 12 (range 3–47) months, the median progression‐free survival (PFS) and overall survival (OS) were 6.5 and 13.3 months. The 1‐year PFS and OS rate were 23.1% and 53.8%. 96.2% of patients experienced at least one adverse event and 26.9% experienced grade 1–2 immune‐related adverse events. PD‐1 inhibitor improved rrENKTL patient survival, and the AEs were controlled. We also observed that the prognostic index for NK cell lymphoma including Epstein‐Barr virus (EBV) (PINK‐E) and the nomogram‐revised risk indexz for ENKTL patients could help identify a potentially unfavorable prognosis in this era of immunotherapy. More attention should be paid to the presence of EBV after anti‐PD‐1 immunotherapy, as it more accurately indicates a poor prognosis.
Rotation, electromagnetic field, and variable thermal conductivity effects on free convection flow past an eternity vertical porous plate
Authors: Bharathi V. , Prakash J. , Vijayaragavan R. , Balaji R. , Pushparaj V. 
Published: December 2022

AbstractThe present research may facilitate the reduction of the number of conversion steps required to include the low output voltages in an electrokinetic biomass process. Variable thermal conductivity and electroosmosis flow have already established great potential in the thermo‐elastic models of various manufacturing industries and have been widely used in energy technologies. As a result, the current framework investigates the characteristics of natural convection flow with the influence of variable thermal conductivity and electroosmosis over an eternity vertical porous plate. Coriolis forces and Hall current effects are considered in the momentum equations, and also thermal radiation and variable thermal conductivity are taken as energy equations. A linear chemical reaction parameter is used in the concentration equation. The equation of Poisson–Boltzmann is exploited to depict the electric potential characteristics within the accelerated plate medium. The pdepe command in Matlab software is used to figure out the numerical solutions to equations about momentum, energy, and concentration. The expressions of fluid transverse velocity, fluid axial velocity, fluid temperature, and concentration profiles are presented as numerical results and also derived vital relevant stream parameters diagrammatically, whereas the numerical values of primary skin friction, secondary skin friction, and Nusselt number are presented in tabular form for various values of pertinent flow parameters. The temperature rises as the strength of the thermal conductivity variable parameter increases. Also, as the values of the Taylor number and the thermal conductivity variable parameter go up, the primary velocity goes down. Similarly, secondary velocity increases in the opposite direction as the Taylor number and thermal conductivity variable parameter increase.
Effect of bimetallic modification on blast furnace slag and its application in low‐temperature selective catalytic reduction
Authors: Zhang Lei , Han Yuzhen , Shu Hao , Zhang Lei , Han Zhikun , Yang Xueying , Chen Ya 
Published: December 2022

AbstractObjectiveIn order to control NOx in low‐temperature flue gases emitted from non‐power industries and to reduce the preparation cost of denitration catalysts, this study uses inexpensive blast furnace slag as raw material to prepare denitration catalysts.MethodsAfter cooling, drying and grinding, the blast furnace slag becomes a powder with considerable fineness and meets the requirements of activity index, which is called GGBS (ground granulated blast furnace slag). Using GGBS as denitration catalyst carrier, the active components M (M = Fe, Co, Ni, Cu and Ce) are loaded on Mn‐based GGBS catalyst using an impregnation method.ConclusionsThe effect of different active components on the denitration performance and sulfur resistance of Mn‐based GGBS catalysts is investigated. The results show that the Mn‐Ce/GGBS catalyst has better denitration performance and sulfur resistance. The Mn‐Ce/GGBS catalyst has a significant denitration performance when load ratio is 2:1. The active component Ce improves the denitration performance of the catalyst, reduces sulfur poisoning and extends the life of the catalyst. The SO2 in the flue gas increases the acid sites on the catalyst surface and improves catalyst activity. The larger the ratios of Mn4+/Mn3+, Ce4+/Ce3+ and Oα/Oβ, the stronger the catalyst activity and the better the denitration performance. © 2022 Society of Chemical Industry (SCI).
Multimodality ultrasound assessment of the spleen: Normal appearances and emergency abnormalities
Authors: Iacobellis Francesca , Schillirò Maria Laura , Di Serafino Marco , Borzelli Antonio , Grimaldi Dario , Verde Francesco , Caruso Martina , Dell'Aversano Orabona Giuseppina , Rinaldo Chiara , Sabatino Vittorio , Cantisani Vito , Vallone Gianfranco , Romano Luigia 
Published: December 2022

AbstractThis paper summarizes the main splenic emergencies and their ultrasonographic findings to orient appropriate patient management. US requires minimal preparation time and allows to examine the parenchyma and to detect intraperitoneal fluid collections, which may be indirect evidence of solid organ injuries. In this paper, we analyze the role of B‐mode, Doppler and Contrast‐Enhanced Ultrasound in the diagnosis of splenic emergencies, with a particular focus on splenic infarction, infection, traumatic injuries and vascular splenic anomalies.
Recurrent symptoms of acute intermittent porphyria after biochemical normalization with givosiran—An ongoing clinical conundrum
Authors: Ma Christopher D. , Faust Denise , Bonkovsky Herbert L. 
Published: December 2022

AbstractA 47‐year‐old woman with acute intermittent porphyria (AIP) has had recurring symptoms after achieving biochemical normalization of her urinary 5‐aminolevulinic acid (ALA), porphobilinogen (PBG), and total porphyrins with givosiran. She has had normal liver tests, mildly decreased renal function, and sustained normal urinary ALA, PBG, and porphyrins with no rebound in her laboratory test results throughout treatment. She continues to tolerate monthly givosiran injections with no adverse effects, but she still experiences what she believes are acute porphyric attacks every 1–2 months.
Local zinc treatment enhances fracture callus properties in diabetic rats
Authors: Innella Kevin , Levidy Michael F. , Kadkoy Yazan , Lin Anthony , Selles Marcus , Sanchez Alexandra , Weiner Adam , Greendyk Joshua , Moriarty Brian , Lauritsen Katherine , Lopez Jonathan , Teitelbaum Marc , Fisher Mark , Mendiratta Dhruv , Ahn David B. , Ippolitto Joseph , Paglia David N. , Cottrell Jessica , O'Connor J. Patrick , Benevenia Joseph , Lin Sheldon S. 
Published: December 2022

AbstractThe effects of locally applied zinc chloride (ZnCl2) on early and late‐stage parameters of fracture healing were evaluated in a diabetic rat model. Type 1 Diabetes has been shown to negatively impact mechanical parameters of bone as well as biologic markers associated with bone healing. Zinc treatments have been shown to reverse those outcomes in tests of nondiabetic and diabetic animals. This study is the first to assess the efficacy of a noncarrier mediated ZnCl2 on bony healing in diabetic animals. This is a promising basic science approach which may lead to benefits for diabetic patients in the future. Treatment and healing were assessed through quantification of callus zinc, radiographic scoring, microcomputed tomography (µCT), histomorphometry, and mechanical testing. Local ZnCl2 treatment increased callus zinc levels at 1 and 3 days after fracture (p ≤ 0.025). Femur fractures treated with ZnCl2 showed increased mechanical properties after 4 and 6 weeks of healing. Histomorphometry of the ZnCl2‐treated fractures found increased callus cartilage area at Day 7 (p = 0.033) and increased callus bone area at Day 10 (p = 0.038). In contrast, callus cartilage area was decreased (p < 0.01) after 14 days in the ZnCl2‐treated rats. µCT analysis showed increased bone volume in the fracture callus of ZnCl2‐treated rats at 6 weeks (p = 0.0012) with an associated increase in the proportion of µCT voxel axial projections (Z‐rays) spanning the fracture site. The results suggest that local ZnCl2 administration improves callus chondrogenesis leading to greater callus bone formation and improved fracture healing in diabetic rats.
Does diversification drive tourism demand? A structural change perspective: Evidence from a casino tourism destination
Authors: Sou Joey Pek‐U , Siu Ricardo Chi Sen 
Published: December 2022

AbstractStructural change in the tourism industry is a potential driving force for tourism demand. Using sectoral‐level data of capital formation, employment, and value‐added as diversification measures, a positive relationship is found to exist between sectoral diversification and tourism demand in Macao. Heterogeneous effects on market origins of varying saturation levels show that sectoral diversification is a potential strategy for attracting visitors from more distant and less saturated origin markets. In order to build up a long‐lasting resilience to external shocks, development policy should focus on cultivating market incentives for private sector stakeholders to participate in the diversification process.
Prosocial motivation can promote the time‐based prospective memory of school‐age children
Authors: Guo Yunfei , Gan Jiaqun , Wang Wei , Ma Jialin , Li Yongxin 
Published: December 2022

AbstractIn real life, we are often motivated to plan things to be performed at specific times in the future. Some of these intended actions help other individuals, and thus involve time‐based prospective memory (TBPM) under prosocial motivational conditions. Children's social development is very rapid, and they have relatively stable prosocial motivation during school age. Few studies have paid attention to this issue. This study focuses on three aspects of this issue: (1) the impact of prosocial motivation on the TBPM of school‐age children, (2) whether there are sex differences in this effect, and, for the first time, (3) the processing mechanism by which prosocial motivation affects TBPM in school‐age children in the framework of the motivation cognitive model. A total of 112 elementary school students, aged between 8 and 12, participated in the experiment, using a 2 (group: prosocial motivation, control) × 2 (sex: boy, girl) between‐subjects design. The results showed that prosocial motivation can significantly reduce children's time difference of TBPM. However, we found no sex differences in the effect of prosocial motivation on TBPM in the above two indicators. With regard to the processing mechanism, we found that the prosocial motivation group paid more attention to external time information throughout the experiment. However, their internal attention and the effectiveness of attention did not improve. These results partially support the motivation cognitive model. Overall, this study found that prosocial motivation relies mainly on external attention to improve the TBPM performance of school‐age children.