bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of food on the pharmacokinetics of WXFL10203614, a potential selective JAK1 inhibitor, in healthy Chinese subjects
Authors: Huang Kai , Shi Yunfei , Chu Nannan , Que Linling , Ding Ying , Qian Zhenzhong , Qin Wei , Gu Xianghong , Wang Jiakun , Zhang Zhiwei , Xu Jianguo , He Qing 
Published: November 2022

Objective: This study was performed to investigate the effect of food on the pharmacokinetics (PK) of WXFL10203614 in healthy Chinese subjects.Methods: This was a randomized, open-label, single-dose, two-treatment (fed vs fasted), two-period, two-sequence, crossover study. 14 eligible subjects were averagely randomized into 2 sequences and then received 10 mg WXFL10203614 under fasted or fed condition. In each period, the blood samples were collected from 0 h (pre-dose) and serially up to 72 h post-dose, and plasma concentrations were detected using the high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method. The effect of food on the PK profile and safety of WXFL10203614 were assessed.Results: 70 subjects were screened, and 14 subjects (10 male and 4 female) were enrolled and completed the study. Under the fasted condition, WXFL10203614 was absorbed rapidly with a Tmax of 0.98 h. The absorption rate was slower, Tmax delayed by 2.98 h, and the Cmax decreased by 16.3% when WXFL10203614 administered after the high-fat and high-calorie diet, other PK parameters were not affected. The 90% confidence intervals (CIs) for the ratio (fed/fasted) of geometric means of the Cmax, AUC0-t and AUC0-∞ were 0.73–1.01, 0.90–1.03 and 0.90–1.03, indicating that the high-fat and high-calorie diet might impact the absorption process of WXFL10203614. Although the Cmax was slightly decreased, there was no significant difference in the Cmax under fasted and fed conditions. Thus, it was not considered clinically significant owing to the small magnitude of changes in Cmax. All Treatment-emergent adverse events (TEAEs) were mild and resolved spontaneously without treatment.Conclusion: Food had no clinically relevant effects on drug system exposure of WXFL10203614. It was well tolerated under fasted and fed conditions in healthy Chinese subjects, so WXFL10203614 could be administered orally with or without food.Clinical Trial Registration: http://www.chinadrugtrials.org.cn/index.html, identifier CTR20191636.
A web-based psychoeducational simulation game for adults in stepfamilies (GSteps)—study protocol for a randomized controlled feasibility trial
Authors: Santos Carina Mota , Costa Maria Emília , Higginbotham Brian Jensen , Martins Mariana Veloso 
Published: November 2022

BackgroundStepfamilies are a prevalent family form. However, less stable than nuclear, first marriage families due to the presence of risk factors such as the absence of social norms and the presence of stepchildren. Stepfamilies have unique educational needs regarding stepparenting and co-parenting issues. The development and documentation of psychoeducational intervention strategies can facilitate dissemination of ongoing studies and promote transparency. This article describes the background, design and protocol of a randomized controlled trial (RCT) evaluating the eficacy and feasibility of a web-based Psychoeducational Simulation Game (GSteps). Behavior-modeling video training (BMT) is used to demonstrate and promote relational skills, stepparenting and co-parenting effective strategies for adults in stepfamilies. A mental health professional will be available within the GSteps platform for clarification or emotional support.Methods/designA RCT design is presented to evaluate the outcomes of a self-administered, interactive and web-based psychoeducational Game targeting dyadic marital adjustment and interpersonal skills as the primary outcomes and remarriage beliefs, family function and stepparenting and co-parenting attitudes as the secondary outcomes. Other outcome measures include satisfaction with GSteps, participants’ knowledge learned after the intervention and a purposive sampling method will be used to access feasibility. The minimum required sample size is 112 participants (56 per condition) randomly allocated either to an experimental group (EG), receiving GSteps intervention, or to a wait-list control group (CG). A survey is conducted electronically. Assessments take place at baseline (T0), after the intervention (T1) and 1-month follow-up (T2).DiscussionThis protocol presents a RCT aimed at evaluating the efficacy of a web-based psychoeducational intervention (GSteps) designed for improving marital, stepparenting and co-parenting skills in adults who live in stepfamilies. The use of the protocol and results of intervention studies may guide the use and refinement of web-based psychoeducational intervention for stepfamilies. Additionally, GSteps may become a tool for health professionals to enhance stepfamily functioning, stepparenting skills, and marital adjustment of remarried adults.
A qualitative study of health care access among African American older adults in a socio-demographically under-resourced region during the COVID-19 pandemic
Authors: Ingram Lucy Annang , Dye Cheryl , Boger Heather , Luo Ye , Hayes Tara 
Published: November 2022

BackgroundIn the U.S., health inequities experienced by the African American community, specifically among those ages 65 and older, have been well-documented in research literature. Alongside the findings regarding disparities in disease prevalence and management, researchers have also highlighted disparities in health care access. Despite recent evidence of health inequities experienced by African Americans during the COVID pandemic, there is little research on the lived experience of this group in this critical time, health care access challenges that may be exacerbated by the pandemic, and the community's outlook for the future in addressing health disparities.MethodsWe conducted a qualitative study of African Americans to gather their perspectives about access to health care, particularly during the COVID-19 pandemic. Study participants consisted of African Americans, ages 50–85 years, who spoke English as their primary language, who resided in one of 17 counties in South Carolina that represent a region of the State known as the corridor of economic disadvantage.ResultsForty-seven telephone interviews were conducted. While research has shown that certain populations experienced health care access disparities during the early COVID pandemic, these disparities did not appear to be exacerbated in our sample. However, participants noted an increase in the use of telehealth, and identified challenges to using this technology. Participants made recommendations about how to address disparities in health care access in their communities.ConclusionOur qualitative approach was useful in obtaining perspectives about access to health care during the COVID-19 pandemic from African American older adults. Continued research with older African Americans, particularly those in under-resourced communities are warranted to further elucidate these findings.
Thulium fiber laser in BPH surgery: Bench to bedside - a systematic review on behalf of YAU Urotechnology Working Group
Authors: Taratkin Mark , Checcucci Enrico , Androsov Alexander , Azilgareeva Camilla , Brill Boris , Morozov Andrey , Puliatti Stefano , Belenchon Ines Rivero , Kowalewski Karl-Friedrich , Rodler Severin , Rivas Juan Gomez , Cacciamani Giovanni E. , Enikeev Dmitry 
Published: November 2022

IntroductionThe Thulium fiber laser (TFL) is a new device that in contrast to the other solid-state YAG-based lasers takes a different approach to pulse formation allowing for two different modes: in the QCW (quasi-continuous wave) function, TFL is convenient for soft tissue surgery and in the SP (Superpulsed) mode it is highly effective in lithotripsy. Thus, unlike the other thulium lasers (Tm : YAG), TFL can be used in a wide range of surgical procedures.Materials and MethodsWe conducted a systematic search in 3 databases: Medline, Scopus and Cochrane library. All original articles (both preclinical and clinical) on TFL application in soft tissue surgery were included in data analysis.ResultsIn terms of its cutting properties, QCW TFL is not inferior to the other thulium lasers, and in fact allows for decreased carbonization (due to lower heat production) compared to continuous lasers (e.g. Tm : YAG). It has been used successfully in endoscopic enucleation of the prostate (EEP) and in en bloc resection of bladder tumors (ERBT). The efficacy and safety of this laser is comparable to TURP and simple prostatectomy, but the recovery period is shorter and the learning curve is slightly superior to other endoscopic procedures. There are no significant differences between TFL and Ho : YAG in terms of efficacy and safety during EEP. Unfortunately, there are no clinical studies that analyse the efficacy and safety of SP TFL in EEP or ERBT.ConclusionTFL is a safe and effective tool for BPH surgery. In terms of parameters, it is in no way inferior to Tm : YAG or Ho : YAG during EEP. However, TFL surpasses these lasers in terms of usability and serviceability. These advantages are likely to render it more popular over time.
A regional classification of time spectral amplitudes in total electron content: Southeastern United States during solar cycle 24
Authors: Burkholder B. L. , Cuellar R. , Nykyri K. , Ma X. , Debchoudhury S. 
Published: November 2022

To investigate the meso-scale structure (100 s of km) of the ionosphere at mid-latitudes, the spectral properties in calculated total electron content (TEC) at a cluster of GPS receivers in and around Florida are analyzed. The ionosphere does not respond exactly the same to periodic solar driving at different locations around the planet, due to the complex electrodynamic interactions of the coupled magnetosphere-ionosphere system. Therefore, at each GPS receiver in the cluster we compare spatio-temporal variations of the spectral amplitudes for diurnal, solar rotation, and seasonal oscillations. The amplitudes for these dominant oscillations are organized with respect to magnetic latitude of the receiver. A low-latitude and high-latitude station are also included to put the mid-latitude ionospheric response into a global context. The amplitudes of diurnal, seasonal, and solar rotation signals are well ordered by magnetic latitude, superposed with meso-scale deviations between stations separated by ∼100s of km. The results suggest that spatio-temporal variations of spectral amplitudes in the mid-latitude ionosphere are not dominated by a single process. This conclusion is based on our finding that at high latitude, the shape of the diurnal signal varies significantly less with solar activity compared to low- and mid-latitudes, and additionally, that the ratio of annual to semi-annual amplitudes fluctuates around 1 with time and from station-to-station only at mid-latitudes.
Le tableau d’Anne-Louis Girodet : Guillaume Thomas Raynal et Jean-Baptiste Belley. La réhabilitation du philosophe ?
Authors: Dorigny Marcel 
Published: November 2022

Ce tableau de Girodet, daté de 1797, s’inscrit dans un triple contexte historique reliant la Révolution française, la Révolution des esclaves de Saint-Domingue et l’évocation des débats des Lumières autour de l’esclavage, de la traite négrière et de la légitimité des colonies à travers la présence marquée du buste de Raynal. Le personnage central, Jean-Baptiste Belley, fut le premier député noir siégeant dans une assemblée nationale française. Le buste du fameux Guillaume-Thomas Raynal est ici représenté aux côtés du député noir. Raynal était mort le 4 avril 1796. Grand pourfendeur de l’esclavage et de la traite dès les années 1770, Raynal avait incarné la lutte radicale contre le système colonial de son siècle. Mais, et c’est essentiel pour interpréter la portée du tableau, Raynal au moment de sa mort était en grande partie déconsidéré aux yeux du public patriote. La rupture entre le philosophe, réputé prophète de la Révolution, et les révolutionnaires est intervenue brutalement, par la lecture devant l’Assemblée constituante de sa fameuse Lettre à l’Assemblée nationale du 31 mai
1791 par laquelle il dénonçait l’oeuvre révolutionnaire, reniant en grande partie les engagements qui avaient fait sa gloire. Ainsi, sa présence au centre du tableau valait rédemption : celui qui avait annoncé la venue imminente d’un « nouveau Spartacus » , s’il n’avait pas su prendre la mesure de la Révolution en cours à Saint-Domingue, en avait tout de même été l’annonciateur. Girodet associait ainsi le philosophe Raynal à Belley, « Spartacus nouveau » , incarnation du Noir libéré et libérateur au sein même de la capitale de la Révolution.
PENGARUH EFEKTIVITAS KEPEMIMPINAN KEPALA SEKOLAH DAN MOTIVASI KERJA TERHADAP KINERJA GURU
Authors: Setiana Adi Robith 
Published: November 2022

The purpose of this study were to describe the influence the Leadership Effectiveness and Motivation on teacher Performance in MTs Serba Bakti Suryalaya Boarding School District of Tasikmalaya. The research method uses a quantitative approach. The population is all teachers in MTs Serba Bakti Suryalaya boarding school district of Tasikmalaya as many as 30 teachers. The sampling technique is saturated sample. Data were analyzed using regression analysis. The results of this study finding that there are significant effect partially and simultaneously of Leadership Effectiveness and Motivation on teacher Performance at MTs Serba Bakti Pondok Pesantren Suryalaya Tasikmalaya Thus, the higher the effectiveness of leadership, the better the performance and the higher the work motivation, the better the performance.
Keywords: Leadership Effectiveness, Motivation, Teacher Performance
KUALITAS PRODUK DALAM MENINGKATKAN MINAT BELI KONSUMEN PADA UMKM DI JAKARTA
Authors: Caniago Aspizain , Rustanto Agung Edi 
Published: November 2022

This study aims to determine the effect of Product Quality on Consumer Buying Interest. This research used a quantitative approach, with data collection techniques using a questionnaire. In this study, the research tests of validity, reliability, correlation analysis, descriptive analysis, simple linear regression, t-test and coefficient of determination were applied. The results showed that the proposed hypothesis was accepted because it showed positive and significant hypothesis test results. The results of this study indicate that the Product Quality has a significant effect on Buying Interest. The contribution of the independent variable (Product Quality) to the dependent variable (Buying Interest) is 72.6%.
Keywords: Product Quality, Consumer Buying Interest, Tokopedia
COMPARATIVO DE PRODUTIVIDADE DO CULTIVAR SOJA SAFRA 2020/21 E 2021/22: ESTUDO DE CASO
Authors: Tubiana Marta , De Oliveira Tressi Pamela Cristina , Alves Feitosa Filho Luiz 
Published: November 2022

O presente trabalho tem como título comparativo de produtividade do cultivar soja, e como objetivo principal verificar qual o impacto sofrido, economicamente, na safra da cultura da soja com a crise hídrica ocorrida no ano safra 2021/2022 em relação ao ano safra 2020/2021. Para desenvolver a pesquisa utilizou-se da metodologia com base em estudo de caso, bibliográfica, quantitativa e dedutiva, em que compara dois períodos e busca compreender os motivos da diferença na produtividade e lucratividade, inicialmente, avaliando a relação entre custo e safra, em uma propriedade no município de Francisco Beltrão- PR, demonstrando indicadores sobre os custos produtivos de cada ano em questão. Adiante, são analisados os principais fatores que levaram a divergência de produção afetada pela crise hídrica e, consequentemente, a lucratividade. Apesar das adversidades, a empresa alcança resultados positivos em decorrência da valorização do cultivar.
Validasi Metode dan Penetapan Kadar Kolesterol Ayam Broiler dengan Metode Lieberman- Burchard
Authors: Sahriawati Sahriawati , Sumarlin Sumarlin , Wahyuni Sri 
Published: November 2022

Analisis kadar kolesterol pada daging ayam broiler merupakan parameter penting yang harus dilakukan karena kandungan lemak dan kolesterol dalam daging ayam broiler relatif tinggi dapat menimbulkan masalah kesehatan. Metode Liebermann-Burchard merupakan metode tidak baku dalam penentuan kolesterol. Untuk menghindari ketidaksesuaian data hasil pengukuran yang dapat menyebabkan adanya kekeliruan, maka laboratorium harus memvalidasi metode tidak baku, metode yang didesain atau dikembangkan laboratorium, metode baku yang digunakan di luar lingkup yang dimaksudkan, dan penegasan serta modifikasi dari metode baku atau dengan kata lain validasi metode bertujuan untuk membuktikan bahwa semua cara atau prosedur pengujian yang digunakan senantiasa mencapai hasil yang diinginkan secara konsisten atau terus menerus. Dalam validasi metode analisis, terdapat beberapa parameter analisis yang harus dipertimbangkan antara lain meliputi ketepatan (akurasi), ketelitian (presisi), spesifitas, linearitas, batas deteksi, batas kuantisasi. Penelitian ini bertujuan untuk memvalidasi metode Liebermann-Burchard serta menganalisis kadar kolesterol ayam broiler berdasarkan kriteria hasil validasi sehingga data yang diperoleh akurat. Kadar kolesterol ayam broiler dianalisis pada bagian yang berbeda yaitu daging bagian paha dan daging bagian dada. Analisis dilakukan deengan spektrofotometer UV visible HACH DR 5000, diperoleh panjang gelombang maksimum 625 nm. Hasil validasi penetapan kadar kolesterol metode Lieberman-Burchard diperoleh adanya hubungan yang linear antara absorbansi dengan kadar kolesterol dengan persamaan y = 0,009x + 0,004 dengan nilai r2 = 0,998. Hasil penetapan akurasi diperoleh %PK sebesar 97,037-108,519% menunjukkan metode ini memiliki ketepatan dan ketelitian yang baik. Hasil penetapan presisi didapatkan nilai KV sebesar 0,506 yang menunjukkan metode tersebut memiliki nilai keterulangan yang baik. Penetapan batas deteksi sebesar 0,511 ppm dan batas kuantitas sebesar 1,703 ppm. Kadar kolesterol daging ayam broiler bagian paha atas diperoleh.59 mg% dan bagian dada dengan kadar kolesterol 65 mg%.
Tecnologías del yo en las prácticas del bioarte
Authors: López-del-Rincón Daniel , Ramírez-Tur Víctor 
Published: November 2022

Las prácticas que se enmarcan en el contexto de relaciones de arte, biología y tecnología permiten aproximarse con complejidad a los diálogos y tensiones que se producen entre identidad y biotecnologías. El recorrido realizado por la historia del bioarte desde la década de los ochenta del siglo XX hasta las primeras décadas del siglo XXI permite analizar las transformaciones experimentadas en la conceptualización del yo entendido como un dispositivo tecnológico. La comprensión de la identidad como tecnología desafía las nociones humanistas heredadas, a la vez que abre las puertas a la construcción (discursiva y material) de identidades porosas y relacionales desde un paradigma postantropocéntrico. El bioarte, a través de una triple definición histórico-artística, biopolítica y transbiológica, constituye un campo de estudio privilegiado para estudiar estas transformaciones identitarias en relación con la tecnobiología. A través del análisis de casos, se plantean tres hitos de la historia del bioarte, que parten del diagnóstico a la propuesta afirmativa: primero, abordando la asimilación entre genoma, textualidad y mecanismos de identificación; segundo, analizando los mecanismos de vigilancia y control inscritos en el modelo genético de la identidad; y, tercero, explorando las posibilidades de apertura relacional que proporcionan las prácticas de alianza multiespecie.
APPORT DE MARKETING STRATEGIQUE SUR LA FIDELISATION DE LA CLIENTELE AU CENTRE HOSPITALIER LUMBULUMBU
Authors: Pierre UTCHINGA WELA 
Published: November 2022

Le souci majeur qui nous a poussés à réaliser cette recherche est celui de plaintes de clients du Centre Hospitalier Lumbulumbu sur le prix de soins médicaux qui n’est pas adapté aux conditions socio-écomiques de la population se trouvant dans cette ville, au vu de cette réalité nous proposons d’appliquer le marketing relationnel et événementiel sur la fidélisation de la clientèle au CHLL, la question suivante a été formulé : quelles actions marketing que le Centre Hospitalier Lumbulumbu doit-il mener pour fidéliser ses patients conventionnés et privés ? Pour mener cette recherche à bon port nous avons recouru aux méthodes historiques, inductives et analytiques. Ces méthodes ont été soutenues par les techniques d’observation directe, questionnaire et documentaire et la technique statistique pour le traitement de données.
En effet, après avoir analysé les réponses fournies par certains clients du CHLL, nous constatons que le réajustement de prix à toutes les catégories de la clientèle, la satisfaction des attentes de malades, collaboration étroite des autorités du CHLL et sa clientèle, la qualité de prise en charge, l’accueil et la disponibilité des médecins spécialistes sont des atouts importants pouvant permettre au Centre Hospitalier Lumbulumbu de fidéliser davantage sa clientèle, car dit-on un pauvre client est un roi face à un investisseur riche du fait qu’il investit en fonction de ce client. Néanmoins, l’aspect marketing étant négligé dans cette structure comme vous les remarquez au graphique N°09, or le marketing est un vecteur de rentabilité indéniable pour toute structure dans le sens que le client est toujours exigeant et volatil.
Brazilian Cerrado native vegetation mapping with Google Earth Engine
Authors: Estrabis Nayara , Pistori Hemerson , Gonçalves Wesley , Marcato Junior José 
Published: November 2022

Cerrado is the second largest biome of South America, with the major extension located in Brazil. This biome is considered a world biodiversity hotspot due to the rich and important biodiversity contrasting with the high threat of destruction. Monitoring using remote sensing approaches is a crucial tool for maintaining and preserving this large-scale biome. Through this context, this study compared and assessed different scenarios with Landsat 8 OLI multispectral bands and Vegetation Indices (EVI, NDVI, and SAVI) for the Cerrado mapping in Mato Grosso do Sul state, Brazil. An amount of 512 sample polygons were distributed into 2 classes: native vegetation and non-native vegetation. The Google Earth Engine platform was applied to the training and classification processes using the Random Forest method. The results showed that using Landsat 8 OLI bands obtained better results than the vegetation indices, with an overall accuracy and kappa index of 97.08% and 0.94, respectively. The mapping verified the existence of 26,80% of Cerrado original native vegetation in Mato Grosso do Sul state in 2019.
Utilização de resíduo do processo Bayer e biomassa da Amazônia para a produção de agregado sintético
Authors: Magalhães Bruno Levy da Silva , Rabelo Daniel Bonifácio , LIMA Ricardo Silva , De Sousa Cruz Júnior Roberto 
Published: November 2022

A mineração é uma das maiores atividades econômicas do estado do Pará, no entanto gera um resíduo nocivo advindo do processo Bayer chamado de lama vermelha (LV), a qual já se mostrou uma matéria-prima bastante potencial na produção de agregados sintéticos. Os agregados podem ser produzidos com uma vasta gama de materiais como a biomassa e nesse trabalho utilizou-se o carvão de caroço de açaí além de outros materiais, como sílica e a argila proveniente do município de São Miguel do Guamá. Produziu-se quatro composições diferentes, nas quais variou-se os teores de LV e carvão, fixando os outros teores nas duas temperaturas de calcinação e analisou-se os resultados através de métodos para determinar a porosidade, absorção de água e massa específica aparente das amostras, além da caracterização por MEV. Os resultados mostraram uma maior porosidade e, consequentemente, menor massa específica para os agregados em menor temperatura e maior teor de carvão vegetal, além disso, foi constatad o aumento da massa específica com o aumento da temperatura. Ademais, nas imagens da análise por MEV mostraram a presença de mulita, importante para a resistência mecânica do material.