bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Potential Role for Impaired Mucosal Integrity in the Generation of Esophageal Pain Using Capsaicin in Humans: An Explorative Study
Authors: Alleleyn Annick M.E. , Keszthelyi Daniel , Rinsma Nicolaas F. , Csekő Kata , Kajtár Béla , Helyes Zsuzsanna , Winkens Bjorn , Masclee Adrian A.M. , Conchillo José M. 
Published: March 2022

INTRODUCTION:
Esophageal pain is mediated by sensory nerves, most importantly by the activation of the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor. TRPV1 is activated and sensitized by a broad range of pungent compounds, as well as inflammatory mediators and tissue irritants. Luminal stressors are suggested to impair the barrier function, which results in consequent activation of these sensory nerve terminals and pain. In this study, we investigated the effect of the perfusion of capsaicin, a TRPV1 agonist, on mucosal impedance and pain in asymptomatic volunteers.

METHODS:
Thirteen asymptomatic volunteers completed a single-blind, saline-controlled, randomized crossover study. Capsaicin or saline was perfused for 30 minutes in the distal esophagus. Visual analog scale pain intensity scores and intraluminal impedance indicating mucosal integrity were determined. Distal and proximal biopsies were obtained 10 minutes later to measure TRPV1 messenger RNA and TRPV1 immunopositivity, as well as the intercellular space area.

RESULTS:
Capsaicin perfusion resulted in significantly greater pain intensity (P = 0.047) and impaired recovery of the mucosal impedance compared with saline-treated controls (P = 0.027). Pain response was significantly associated with decreased mucosal impedance. Similar dynamics were seen in the proximal esophagus, but mucosal impedance recovered entirely to the preinfusion values there. There was a significant association between mucosal impedance and intercellular space width in the distal esophagus. TRPV1 transcription and expression were not significantly altered within this observation period.

DISCUSSION:
Esophageal capsaicin perfusion results in pain, which is likely to be explained by impaired mucosal impedance and defective restoration capacity in the distal esophagus.
Development of Social Skills with Traditional Games: An Experimentation with the Game Mallogo
Authors: Tasnim Aeni , Damayanti Eka , Afiif Ahmad 
Published: March 2022

Purpose – This study aims to prove the improvement of social development through the traditional game of mallogo for children aged 5-6 years at Ponre, Gantarang, Bulukumba.Design/methods/approach – This study is a quantitative research using experimental methods. The research design used is a one-group pretest-posttest design. The population in this study are 8 children aged 5-6 years who live in Ponre, Gantarang, Bulukumba and whole child are sample in this research. The data collected throught developmental assessment using observation base on children age 5-6 social and emotional development indicators was set by Minister of Education and Culture No. 137 of 2014 concering National Standard for Early Childhood Education. The data analysis technique used is Wilcoxon’s non-parametric statistic test.Findings – The results of this study are that the average value of the pre-test was 25,625, while the average value of the post-test was 54.875. Wilcoxon test obtained the calculated value of -2.52 Zcount, which is smaller than the value of Ztable of -1.96, which was carried out with a two-tailed test (-2.52 < -1.96). The results show an increase in social development through traditional mallogo games for children aged 5-6 years at Ponre, Gantarang, Bulukumba.Research implications/limitations – This study has implications for developing traditional games in children’s social skills. In the future, the number of participants needs to be increased. Parametric statistical tests are needed to strengthen the research results.Practical implications – This study has practical implications for experimental studies of children’s social abilities.Originality/value – This study contributes to the development of the study of children’s play. In addition, this research provides a new perspective on children’s social development through the traditional game method.
Paper type: Research paper
Learning Technology on Early Childhood Education: The COVID-19 Pandemic Case
Authors: Nurul Fazriah Rifai  , Emilly Nzunda Ibrahim , Kusumawardani Ratih , Fatimah Atin 
Published: March 2022

Purpose – This study aims to analyze the learning technology used by early childhood education teachers during the COVID-19 pandemic, this research describes the evaluation of learning technology used by teachers in early childhood education during the COVID-19 pandemic.Design/methods/approach – The research method is quantitative research. Data was collected using a questionnaire method and strengthened by interviews to obtain in-depth data. Questionnaires were distributed to 30 institutions and early childhood education teachers in Serang District, Serang City, Banten Province. Interviews as reinforcing data were conducted using semi-structured interviews. The research sample was obtained through purposive random sampling. Conclusions were drawn from the data analysis process by using quantitative descriptive data analysis techniques.Findings – Learning technology in early childhood education used by teachers of early childhood education institutions in Serang District, Serang City, Banten Province are whatsapp, zoom meeting, and youtube. Teachers can use learning technology for early childhood education optimally. However, the obstacles obtained consist of: signal interference, limited internet data, and limitations of parents assistance or guardians of students in having gadgets.Research implications/limitations – This study has limitations on early childhood education learning in one area of Indonesia. The learning technology used by teachers also focuses on early childhood education. Therefore, higher education levels will have different learning technologies that teachers use.Practical implications – This study implies that learning technology in early childhood education during the COVID-19 pandemic can use whatsapp, zoom meetings, and youtube.Originality/value – This study contributes to the understanding in early childhood education teachers in utilizing learning technology such as whatsapp, zoom meeting, and youtube in carrying out the teaching and learning process during the COVID-19 pandemic.
Paper type: Research paper
Metal, la confusión en la diversidad musical
Authors: Escobar Melgarejo David 
Published: March 2022

Todo tipo de creación musical posee un predecesor fácilmente identificable, en este caso, para el género musical llamado metal , se parte de una diversidad musical y cultural tan vasta que puede generar confusión, incluso en su interior surgen una gran cantidad de géneros o subgéneros que complican aún más una posible identificación. Así entonces, este artículo se propone realizar un acercamiento al metal tanto para sus seguidores como para aquellos que nunca se han acercado a esta música.
Management of root-knot nematode infection by using fly ash and Trichoderma harzianum in Capsicum annum plants by modulating growth, yield, photosynthetic pigments, biochemical substances, and secondary metabolite profiles
Authors: AHMAD Gufran , KHAN Amir , ANSARI Safiuddin , KHAN Abrar A. , ELHAKEM Abeer , SAMI Rokayya , MOHAMED Heba I. 
Published: March 2022

A nematicide is a type of chemical pesticide used to kill plant-parasitic nematodes. Nematicides have tended to be broad-spectrum toxicants, possessing high volatility or other properties that promote migration through the soil. In addition, the nematicides used are more expensive and have adverse effects on health and the environment, so it must use more eco-friendly and less expensive alternative methods to control root-knot nematodes (Meloidogyne incognita). Chili (Capsicum annum) suffers from nematode infestation, which reduces its quality and quantity. Therefore, the goal of this research was to assess the effect of different doses of fly ash (FA) mixed soil (5%, 10%, 15 and 20% FA) with two doses of Trichoderma harzianum (1 g and 2 g) for the management of root-knot nematode infection in chili crop. The results showed that significant enhancement in plant growth, yield, chlorophyll, and carotenoid content, protein, carbohydrate, amino acid, tryptophan, indole acetic acid, phenolics, flavonoids, proline, and nitrate reductase content of chili plants was recorded at 10% fly ash with 2 g of T. harzianum (T6). The inoculated plants registered the greatest damage with galling indexes. The lowest galling index was estimated at the T6 treatment. At higher levels of FA + combined with both doses of T. harzianum, nematode could not survive that’s why eighter galls or egg masses were observed. Nematodes may have ceased to function, lost their activity, and hence been unable to resist the stress of fly ash and T. harzianum set. The application of T. harzianum with a lower dose (10%) of fly ash to control the nematode favored plant growth in general. In conclusion, 10% fly ash and 2 g of T. harzianum have the ability to operate as growth promoters and biocontrol agents for M. incognita.
Taxonomy, phytochemical and bioactive compounds and potential use as material with different drying methods of Alpinia latilabris Ridl. new record from Thailand
Authors: CHUMROENPHAT Theeraphan , SAENSOUK Surapon 
Published: March 2022

Alpinia latilabris Ridl., a new record from Thailand, has great potential for use as a material for food and traditional medicine. Dried samples preserve the quality and avoid the degradation of phytochemicals. The aim here was to determine the taxonomy and changes in the phytochemical and bioactive compounds when using different drying methods as well as the antioxidant properties in this first report for this species. The results show that freeze-dried samples had greater quality volatile compounds, bioactive compounds, organic acid, phenolic acid, flavonoids and antioxidants compared with a fresh sample while having a microstructure similar to that of the fresh sample. The major volatile compounds were 1,8-cineole in fresh and dried samples, as confirmed by FTIR spectra. The bioactive chemicals are sensitive to thermal drying and sunlight due to degradation of the phytochemicals. This result can be useful information and be applied to the preparation of material for further development of functional foods, medicinal plants or cosmetics.
1929 BUNALIMININ TÜRKİYE’YE YANSIMALARI VE ATATÜRK’ÜN ÜÇ AYLIK ANADOLU GEZİSİ
Authors: GEZER ESEN Gülnaz 
Published: March 2022

Türkiye’nin siyasi bağımsızlığının onaylanacağı Lozan Barış görüşmelerine ara verildiği dönemde düzenlenen Türkiye İktisat Kongresi (17 Şubat-4 Mart 1923), iktisadi bağımsızlığın altının çizilmesi açısında önemlidir. Kongrede alınan kararlarda özel girişimciliğin desteklenmesi ön plana çıkmış olmakla birlikte, Lozan Barış Antlaşması’nda gümrük tarifelerine 1929 yılına kadar geçerli olacak kısıtlamaların getirilmesi, Türkiye Cumhuriyeti’nin spesifik gümrük tarifelerini uygulamasını engellemiştir. 1929 Dünya Ekonomik Bunalımı tüm dünyayı olduğu gibi Türkiye Cumhuriyeti’ni de olumsuz yönde etkilemiştir. Bu sıkıntılı sürecin en az zararla atlatabilmesi adına bir yandan özel girişime devlet desteği verilip, ekonomik hayatı düzenleyen çeşitli tedbirler alınırken; diğer yandan da toplumsal gerilimin çoğulcu bir siyasi yöntem ile giderilmesi düşünülmüş ve Serbest Cumhuriyet Fırkası kurulmuştur. Ancak bahse konu partinin kuruluşu beklenen etkiyi yapmadığı gibi siyasi ortamın daha da gerilmesine neden olmuş ve kısa bir süre sonra da kendisini feshetme kararı almıştır. Bu dönemde Mustafa Kemal (Atatürk) tarafından, Serbest Cumhuriyet Fırkası’nın fesih sebeplerini halka birinci ağızdan anlatmak, devrimlerin halk tarafından ne derece benimsendiğinin gözlemlemek ve ekonomik krizin etkilerini yakından müşahade ederek, çözüm üretmek amacıyla üç ay süren Anadolu gezisi icra edilmiştir.
1929 Bunalımı’nın Türkiye Cumhuriyeti’ne ekonomik ve siyasal yansımalarını ve sıkıntıların aşılmasına yönelik çözüm arayışlarını değerlendirmek üzere yapılan bu çalışmada öncelikle dönemin gazeteleri ve arşiv belgelerinden yararlanılmıştır. Çalışmanın çerçevesini, Türkiye Cumhuriyeti’nin Osmanlı Devleti’nden devraldığı ekonomik miras, SCF’nin kurulması ve feshedilmesini zorunlu kılan koşullar ile Mustafa Kemal (Atatürk)’ün Anadolu gezileri esnasındaki tespitleri ve çözüm çabaları oluşturmuştur.
A CURRICULARIZAÇÃO DA EXTENSÃO NA GRADUAÇÃO EM SAÚDE: A EXPERIÊNCIA DE UM CURSO DE ENFERMAGEM
Authors: Rocha Sibele Pontes , Ponte Neto Osmar Arruda da , Farias Quiteria Larissa Teodoro , Maciel Gabriel Pereira , Silva Ívina Alessa Bispo , Sousa Joaquim Ismael Teixeira de , Cavalcante Ana Suelen Pedroza , Vasconcelos Maristela Inês Osawa 
Published: March 2022

Este estudo tem como objetivo descrever o processo de curricularização da extensão em um curso de graduação em enfermagem. Modela-se em um relato de experiência desenvolvido por meio da vivência dos autores no módulo curricular Práticas Interdisciplinares em Ensino Pesquisa e Extensão I, do 4º semestre do curso de graduação em enfermagem da Universidade Estadual Vale do Acaraú, Sobral, Ceará, estruturando-se em dois eixos analíticos, a saber: “Organização didático-pedagógica do PIEPE I” e “O PIEPE I e sua contribuição social e para a formação em enfermagem”. O módulo perfaz uma carga-horária de 80h, onde, 12h são destinadas às atividades teóricas, que integram ensino e pesquisa e 68h destinadas às atividades de extensão, que se desenvolve de forma integrada ao currículo, proporcionando ao acadêmico vivências no âmbito da saúde do adolescente em território vivo e o desenvolvimento de habilidades e competências que ultrapassam o saber técnico. Além de agregar conhecimento para o autocuidado em saúde, os adolescentes passam a ter novas perspectivas se reconhecendo como agentes importantes na sociedade. Compreende-se que apesar dos desafios para a implementação da curricularização da extensão, o curso de Enfermagem da UVA tem buscado avançar nesse sentido, favorecendo a melhoria do ensino e o desenvolvimento do papel social da universidade.
Laboratory-Based Mate Choices of Two Eccritotarsus Species (Hemiptera: Miridae) Used as Biological Control Agents of Water Hyacinth, Pontederia (Eichhornia) crassipes (Pontederiaceae), in South Africa
Authors: Mnguni Sandiso , Peter Heshula Lelethu Unathi-Nkosi 
Published: March 2022

Abstract
Many biological control agents have been released to manage the water hyacinth, Pontederia (Eichhornia) crassipes (C. Martius) Solms-Laubach (Pontederiaceae). They include two Eccritotarsus sources from Brazil and Peru. Distinguishing features between the two were found, necessitating their redescription. The Brazil source remained Eccritotarsus catarinensis (Carvalho), whereas the Peru source is Eccritotarsus eichhorniae Henry. Our objectives in this laboratory study were to assess the mate choice in the two species and, thus, determine which species performs better than the other. Mate choice in the form of no-choice, bichoice, and multichoice tests were conducted within and between species in a 3:1, 2:1, and 1:1 sex ratios. The E. catarinensis pair had short copula latency but long copula duration in multichoice experiments, whereas the E. eichhorniae pair had short copula latency but long copula duration in no-choice experiments. In no-choice and bichoice experiments, E. eichhorniae♀ and E. eichhorniae♂ outcompeted E. catarinensis♀ and E. catarinensis♂. In multichoice experiments, E. catarinensis♂ outcompeted E. eichhorniae♂, whereas E. eichhorniae♀ outcompeted E. catarinensis♀. Despite being shown to be more fecund, E. eichhorniae is likely not to outcompete E. catarinensis where the two species co-occur and that E. catarinensis♂ and E. eichhorniae♀ will outcompete their counterparts. Previous research indicated that when E. catarinensis♂ and E. eichhorniae♀ are crossed, they produce few offspring, underscoring the need to confirm if the two species will coexist, compete, or displace each other in their natural habitats. Our findings further support that prezygotic reproductive isolation mechanisms led to the speciation of these species.
Variabilidad de densidad en sentido radial y dentro de un anillo de crecimiento en Pinus caribaea var. hondurensis de 25 años de edad
Authors: Márquez-Carrero Gabrialy , Valero Styles W. , León-Hernández Williams J. , Gutiérrez-Gotera Ilvania J. , Maldonado-Rangel Julio C. 
Published: March 2022

El presente trabajo corresponde al estudio de la densidad de madera seca al aire en 6 árboles de Pinus caribaea var. hondurensis (Sénécl) W. Barret & Golfari (Pinaceae) provenientes de plantaciones de 25 años de edad establecidas en Uverito (estado Monagas, Venezuela). Se tomaron muestras en 3 posiciones de la sección transversal del tallo: adyacencias de médula (muestra de todo el anillo de crecimiento), y a la mitad del radio (muestra en madera temprana y madera tardía) y adyacencias de zona cambial (muestra de todo el anillo de crecimiento). La densidad se determinó bajo la Norma DIN 52-182. A través de la sección transversal se encontró un incremento de la densidad desde las adyacencias de médula hacia la zona cambial (0,595 en adyacencias de médula; 0,681 en el punto medio y 0,820 g/cm³ en las adyacencias de la zona cambial). Por otra parte, el peso específico de madera tardía (0,806 g/cm³) mostró valores notablemente superiores con respecto a la madera temprana (0,557 g/cm³). De acuerdo a la prueba de Tukey (α = 0,01), existen diferencias estadísticamente significativas entre el peso específico de adyacencias de médula con respecto a las cercanías del cambium; así como también las diferencias encontradas entre madera temprana y madera tardía del anillo de crecimiento tuvieron significancia estadística.
Kode Etik Profesi Akuntan Publik Ditinjau dari Perspektif Islam
Authors: Jayasi Febi annuri jayasi 
Published: March 2022

Penelitian ini bertujuan untuk menganalisa mengenai Kode Etik Profesi Akuntan Publik Ditinjau dari Perspektif Islam. Penelitian ini merupakan penelitian kualitatif dengan studi kepustakaan (library research). Jenis penelitian kepustakan menggunakan teks-teks Alquran dan Hadist atau lebih sering disebut studi teks kewahyuan. Untuk metode analisisnya menggunakan Metode Analisis Isi. Pemahaman atas Lima prinsip etika profesi Akuntan Publik Dari perspektif Islam yang berlandaskan Alquran dan hadist akan menjadikan Akuntan Publik yang berintegritas yang dibangun dari kecerdasan spiritual dan emosional, berpikiran objektif dalam mengambil keputusan atau penilaian mengenai suatu hal dengan bersikap adil dan berhati-hati dengan penuh pertimbangan, mendorong untuk bersikap hati-hati terhadap pekerjaan, memiliki sifat Amanah dan menjaga kerahasiaan informasi. Maka dari itu ajaran Islam memberikan petunjuk kepada akuntan publik untuk senantiasa memahami dan mematuhi perintah dan menjauhi larangan Allah Swt.
Connaître les forêts anciennes et matures : comment ? pourquoi ?
Authors: Savoie Jean-Marie , Thomas Marie , Cateau Eugénie , Gouix Nicolas , Paccard Pierre 
Published: March 2022

Les forêts anciennes et matures constituent aujourd’hui en Europe occidentale les forêts les plus proches de la forêt dite primaire. Leurs attributs leur confèrent un fort potentiel d’accueil de biodiversité, particulièrement saproxylique. Depuis une quinzaine d’années, elles font l’objet d’inventaires, d’évaluations ou de cartographies sur une grande partie du territoire métropolitain. De nombreux projets sont en cours ou émergent, portés par diverses structures (parcs nationaux ou régionaux, réserves naturelles, Office national des forêts, conservatoires d’espaces naturels, conservatoires botaniques…). Les protocoles varient d’un projet à l’autre mais certains attributs sont relevés de façon quasi systématique. Les objectifs affichés diffèrent mais sont axés autour de quelques grands thèmes : prise en compte des forêts anciennes et matures dans les chartes ou les plans de gestion des aires protégées, dans les documents de gestion durable, dans l’élaboration de trames de vieux bois pertinentes, dans des projets de recherche visant à améliorer la connaissance de leur biodiversité ou de leur fonctionnement, dans des actions de communication et de sensibilisation en faveur de leur préservation.
Le rewilding pour tendre vers la pleine naturalité
Authors: Rayé Gilles 
Published: March 2022

Au cours du réchauffement holocène, la dynamique forestière est affectée par l’absence de la mégafaune éliminée au Pléistocène. Plus tard, la déforestation d’origine anthropique atteint son apogée en France au XIXe siècle. Avec l’exode rural, des forêts férales pleines de naturalité se mettent en place par libre évolution sur d’anciennes terres agricoles. Le phénomène est bien marqué dans les massifs montagneux. En France, dès les années 1950, des réintroductions d’espèces vont permettre de restaurer des fonctions écologiques. Le rewilding, un mix de libre évolution, de réintroductions d’espèces et d’ingénierie écologique constitue la voie à privilégier pour remettre en fonctionnement les écosystèmes et lutter contre la sixième extinction des espèces. Le parc naturel régional du Vercors a montré l'exemple pour retrouver la pleine naturalité grâce à des espaces en libre évolution et de multiples réintroductions qui ont permis de restaurer des fonctions écologiques.
Telaah ‘Urf Terhadap Adat Larangan Nikah Mbarep Telon di Desa Tawun Ngawi
Authors: Candra Kumala Putri Dian , Aini Shofwatul 
Published: March 2022

For the Muslim community, guidelines regarding marriage are contained in the Qur'an, hadith, positive law, and Urf. In practice, people still use traditions in carrying out marriages, one of which is Mbarep Telon, meaning that the marriage is carried out by the prospective bride and groom who are both the first child and one of the parents is also the first child. The focus taken from this research is related, first, how to find out 'urf against the practice of prohibiting mbarep telon marriages in Tawun Ngawi Village? Second, how do we 'urf against the tradition of slametan redeeming children as a rejection of balance in the ban on mbarep telon marriages in Tawun Ngawi Village? This research uses ushul fiqh approach with qualitative research type and uses interview, observation, and documentation techniques. Based on this research, it can be said that, First, the practice of prohibiting mbarep telon marriage meets the requirements accepted by 'urf as a source of law and is included in 'urf sahih because in this custom it is as a caution in determining a partner. Second, that the slametan tradition of redeeming children as a rejection of balance in the prohibition of mbarep telon marriage is included in 'urf typical, 'urf fi'li, and 'urf sahih.
Bagi masyarakat muslim, pedoman mengenai perkawinan termaktub dalam Alquran, hadits, hukum positif, serta Urf. Dalam praktiknya, masyarakat masih menggunakan tradisi dalam melaksanakan perkawinan, salah satunya Mbarep Telon, artinya pernikahan dilakukan oleh calon mempelai yang keduanya adalah anak pertama dan salah satu orangtuanya juga anak pertama. Fokus yang diambil dari penelitian ini yaitu terkait, pertama, bagaimana tinjauan ‘urf terhadap praktik larangan nikah mbarep telon di Desa Tawun Ngawi? Kedua, bagaimana tinjauan ‘urf terhadap tradisi slametan tebus anak sebagai tolak balak dalam larangan nikah mbarep telon di Desa Tawun Ngawi? Penelitian ini menggunakan pendekatan ushul fiqih dengan jenis penelitian kualitatif serta menggunakan teknik wawancara, observasi, dan dokumentasi. Berdasarkan pembahasan penelitian ini dapat disimpulkan bahwa, pertama bahwasanya praktik larangan nikah mbarep telon memenuhi syarat-syarat diterima ‘urf sebagai sumber hukum dan termasuk dalam ‘urf shahih karena dalam adat ini bersifat sebagai penghati-hatian dalam menentukan pasangan. Kedua, bahwasanya tradisi slametan tebus anak sebagai tolak balak dalam larangan pernikahan mbarep telon termasuk dalam ‘urf khass, ‘urf fi’li, dan ‘urf shahih.