bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prevalence and Success Factor of Ibuprofen and Paracetamol Administration for Neonates with Patent Ductus Arteriosus at RSUD Dr. Soetomo
Authors: Rodia Amanata Rofiq  , I Ketut Alit Utamayasa  , Nurina Hasanatuludhhiyah  , Arthur Pohan Kawilarang  
Published: July 2022

Background: Four thousand neonates with Persisten Ductus Arteriosus every year in Indonesia. There are twotreatment options to treat Persistent Ductus Arteriosus, they are surgery and pharmacological therapy. Ibuprofenand paracetamol can be used as pharmacological therapy for Persistent Ductus Arteriosus with minimal sideeffects.Objective: To analyze the prevalence and success factors in giving ibuprofen and paracetamol in neonates withpersistent ductus arteriosus.Method: This research is an observational analytic research with cross-sectional method. The determination of theresearch sample uses a total sampling technique by taking all members of the population in accordance with theconditionsfrom January, 2016 to March , 2020. Bivariate analysis was perform using the Spearman rank test with95% confidence interval (α=0.05).Result: From 51 samples that met the inclusion criterias, it was found that the most criterias were male (66.67%),normal birth weight (60.78%), aterm (76.48%), moderate defect size before being administrated pharmacologicaltherapy (47.06%), pharmacological therapy using paracetamol (88.24%), atrial septal defect in the cardiaccomorbidities category (21.74%) and hyperbilirubinemia in the non-cardiac comorbidities category (13.04%). Themajority of lumen defects in neonates were closed completely after being administrated pharmacological therapy(72.55%). Statistical test results of spearman rank showed that no significant relationship between birth weightand pharmacological therapy in RSUD Dr. Soetomo. There was a significant relationship between gestation andpharmacological therapy (p = 0.000; r = -0.495; r2 = 0.237, 95% CI). There was a significant relationship between thesize of the ductus arteriosus defect before therapy and pharmacological therapy (p = 0.001; r = -0.435; r2 = 0.211,95% CI).
Conclusion: The success factors in administrating ibuprofen and paracetamol for neonates with persistent ductusarteriosus in RSUD dr. Soetomo from January 1, 2016 to March 3, 2020 were affected by gestation period and sizeof the ductus arteriosus defect prior to pharmacological therapy.
Review on pediatric seizures - a prospective study on drug utilization pattern and its outcome
Authors: K Mamatha , S Revathi , P Venkatesh 
Published: July 2022

OBJECTIVES: The objective of this study is to evaluate the drug utilization pattern and to observe possible treatment outcomes.
METHODS: A Non-experimental prospective observational study has been carried out in tertiary care hospital for a period of six months. A total number of 181 pediatric inpatients of age 1- 14 years with seizures were included and evaluated. The patient’s case history was collected based on a data collection form designed for the study.
RESULTS: In our study, we observed that female patients are more prevalent. Prevalence of seizures is high among the age group 1-5years and low among 11-14 years. Tonic-clonic (51.3%) types of seizures were commonly observed, followed by febrile seizures (19%). Phenytoin is the most prescribed drug followed by sodium valproate. Monotherapy is observed mostly. The outcome of the therapy is measured by seizure-free period, among which seizure-free observed are more than 74.1%. The incidence of ADRs in the study group is less (6.6%) and phenytoin is the drug with more number of ADRs. Medication adherence is measured in known epileptic patients (n=67) using MMAS, medium adherence seems to be more (49%).
CONCLUSION: This study strongly highlights that the Clinical pharmacist has a pivotal role in conducting drug utilization studies that help in comparing the ongoing regimen with the standard treatment guidelines so as to promote the stupendously rational use of drugs and to minimize or control the incidence of ADRs.
NICER X-Ray Observations of Eta Carinae during Its Most Recent Periastron Passage
Authors: Espinoza-Galeas David , Corcoran M. F. , Hamaguchi K. , Russell C. M. P. , Gull T. R. , Moffat A. F. J. , Richardson N. D. , Weigelt G. , Hillier D. John , Damineli Augusto , Stevens Ian R. , Madura Thomas , Gendreau K. , Arzoumanian Z. , Navarete Felipe 
Published: July 2022

Abstract
We report high-precision X-ray monitoring observations in the 0.4–10 keV band of the luminous, long-period colliding wind binary Eta Carinae, up to and through its most recent X-ray minimum/periastron passage in 2020 February. Eta Carinae reached its observed maximum X-ray flux on 2020 January 7, at a flux level of 3.30 ×10−10 ergs s−1 cm−2, followed by a rapid plunge to its observed minimum flux, 0.03 × 10−10 ergs s−1 cm−2, near 2020 February 17. The NICER observations show an X-ray recovery from the minimum of only ∼16 days, the shortest X-ray minimum observed so far. We provide new constraints for the “deep” and “shallow” minimum intervals. Variations in the characteristic X-ray temperatures of the hottest observed X-ray emission indicate that the apex of the wind–wind “bow shock” enters the companion’s wind acceleration zone about 81 days before the start of the X-ray minimum. There is a steplike increase in column density just before the X-ray minimum, probably associated with the presence of dense clumps near the shock apex. During the recovery and after, the column density shows a smooth decline, which agrees with previous N

H
measurements made by Swift at the same orbital phase, indicating that the changes in the mass-loss rate are only a few percent over the two cycles. Finally, we use the variations in the X-ray flux of the outer ejecta seen by NICER to derive a kinetic X-ray luminosity of the ejecta of ∼1041 ergs s−1 near the time of the “Great Eruption.”
Superclustering with the Atacama Cosmology Telescope and Dark Energy Survey. I. Evidence for Thermal Energy Anisotropy Using Oriented Stacking
Authors: Lokken M. , Hložek R. , Engelen A. van , Madhavacheril M. , Baxter E. , DeRose J. , Doux C. , Pandey S. , Rykoff E. S. , Stein G. , To C. , Abbott T. M. C. , Adhikari S. , Aguena M. , Allam S. , Andrade-Oliveira F. , Annis J. , Battaglia N. , Bernstein G. M. , Bertin E. , Bond J. R. , Brooks D. , Calabrese E. , Rosell A. Carnero , Kind M. Carrasco , Carretero J. , Cawthon R. , Choi A. , Costanzi M. , Crocce M. , Costa L. N. da , Pereira M. E. da Silva , Vicente J. De , Desai S. , Dietrich J. P. , Doel P. , Dunkley J. , Everett S. , Evrard A. E. , Ferraro S. , Flaugher B. , Fosalba P. , Frieman J. , Gallardo P. A. , García-Bellido J. , Gaztanaga E. , Gerdes D. W. , Giannantonio T. , Gruen D. , Gruendl R. A. , Gschwend J. , Gutierrez G. , Hill J. C. , Hilton M. , Hincks A. D. , Hinton S. R. , Hollowood D. L. , Honscheid K. , Hoyle B. , Huang Z. , Hughes J. P. , Huterer D. , Jain B. , James D. J. , Jeltema T. , Kuehn K. , Lima M. , Maia M. A. G. , Marshall J. L. , McMahon J. , Melchior P. , Menanteau F. , Miquel R. , Mohr J. J. , Moodley K. , Morgan R. , Nati F. , Page L. , Ogando R. L. C. , Palmese A. , Paz-Chinchón F. , Malagón A. A. Plazas , Pieres A. , Romer A. K. , Rozo E. , Sanchez E. , Scarpine V. , Schillaci A. , Schubnell M. , Serrano S. , Sevilla-Noarbe I. , Sheldon E. , Shin T. , Sifón C. , Smith M. , Soares-Santos M. , Suchyta E. , Swanson M. E. C. , Tarle G. , Thomas D. , Tucker D. L. , Varga T. N. , Weller J. , Wechsler R. H. , Wilkinson R. D. , Wollack E. J. , Xu Z. 
Published: July 2022

Abstract
The cosmic web contains filamentary structure on a wide range of scales. On the largest scales, superclustering aligns multiple galaxy clusters along intercluster bridges, visible through their thermal Sunyaev–Zel’dovich signal in the cosmic microwave background. We demonstrate a new, flexible method to analyze the hot gas signal from multiscale extended structures. We use a Compton y-map from the Atacama Cosmology Telescope (ACT) stacked on redMaPPer cluster positions from the optical Dark Energy Survey (DES). Cutout images from the y-map are oriented with large-scale structure information from DES galaxy data such that the superclustering signal is aligned before being overlaid. We find evidence of an extended quadrupole moment of the stacked y signal at the 3.5σ level, demonstrating that the large-scale thermal energy surrounding galaxy clusters is anisotropically distributed. We compare our ACT × DES results with the Buzzard simulations, finding broad agreement. Using simulations, we highlight the promise of this novel technique for constraining the evolution of anisotropic, non-Gaussian structure using future combinations of microwave and optical surveys.
Ensemble Simulations of the 2012 July 12 Coronal Mass Ejection with the Constant-turn Flux Rope Model
Authors: Singh Talwinder , Kim Tae K. , Pogorelov Nikolai V. , Arge Charles N. 
Published: July 2022

Abstract
Flux-rope-based magnetohydrodynamic modeling of coronal mass ejections (CMEs) is a promising tool for prediction of the CME arrival time and magnetic field at Earth. In this work, we introduce a constant-turn flux rope model and use it to simulate the 2012 July 12 16:48 CME in the inner heliosphere. We constrain the initial parameters of this CME using the graduated cylindrical shell (GCS) model and the reconnected flux in post-eruption arcades. We correctly reproduce all the magnetic field components of the CME at Earth, with an arrival time error of approximately 1 hr. We further estimate the average subjective uncertainties in the GCS fittings by comparing the GCS parameters of 56 CMEs reported in multiple studies and catalogs. We determined that the GCS estimates of the CME latitude, longitude, tilt, and speed have average uncertainties of 5.°74, 11.°23, 24.°71, and 11.4%, respectively. Using these, we have created 77 ensemble members for the 2012 July 12 CME. We found that 55% of our ensemble members correctly reproduce the sign of the magnetic field components at Earth. We also determined that the uncertainties in GCS fitting can widen the CME arrival time prediction window to about 12 hr for the 2012 July 12 CME. On investigating the forecast accuracy introduced by the uncertainties in individual GCS parameters, we conclude that the half-angle and aspect ratio have little impact on the predicted magnetic field of the 2012 July 12 CME, whereas the uncertainties in longitude and tilt can introduce relatively large spread in the magnetic field predicted at Earth.
Le plaisir et la honte : des affects politiques
Authors: Fœssel Michaël , Gros Frédéric , Bujon Anne-Lorraine , Riquier Camille 
Published: July 2022

Le plaisir peut-il redevenir un moteur d’émancipation ? La honte face aux injustices porteuse d’énergie transformatrice ? Les philosophes Michaël Fœssel et Frédéric Gros invitent à réinvestir la dimension politique de ces affects, capables de réinscrire les corps individuels dans un horizon collectif.
Exploiter un grand stade et sécuriser le spectacle sportif
Authors: Lestrelin Ludovic , Soulé Bastien 
Published: July 2022

Depuis les années 1990, l’économie du football professionnel européen a connu de profondes évolutions, les clubs se muant en entreprises de spectacle. Documentant ces transformations, la littérature sociologique a pointé leur lien avec les questions de sécurité. Avec la hausse des impératifs commerciaux, la sécurisation des stades vise, en effet, à protéger et à améliorer leur potentiel productif et marchand. L’objet de cet article est de discuter cette thèse. L’enquête menée sur le cas de l’Olympique lyonnais (OL) montre que la convergence des intérêts économiques et sécuritaires ne va pas de soi, d’autant moins en contexte de croissance organisationnelle. L’analyse de la préparation, du déroulement et des suites d’un match de coupe d’Europe marqué par de violents incidents entre supporters permet d’illustrer les contraintes auxquelles sont confrontés les personnels du club. Un enjeu de leur travail est de réussir à articuler la maximisation des recettes commerciales avec la gestion des risques, dont celui très aigu lié au hooliganisme.
La consultation gynécologique, une instance paradoxale dans la socialisation des jeunes femmes à la sexualité
Authors: Koechlin Aurore 
Published: July 2022

L’article interroge le rôle de la consultation gynécologique dans la socialisation des jeunes femmes à la sexualité en partant d’un apparent paradoxe : alors que la sexualité fait partie des compétences de la gynécologie médicale, il n’en est apparemment que peu question en consultation. Nous verrons que la sexualité est moins effacée que reconfigurée dans ce cadre. Ainsi, la consultation gynécologique socialise principalement à une vision médicale de la sexualité, qui doit être contraceptée et dont les conséquences potentielles (grossesses non prévues, infections sexuellement transmissibles [IST]) doivent être constamment prévenues et ponctuellement dépistées. Quand la sexualité est abordée plus directement par le biais de la sexologie, même si cela demeure minoritaire, le discours adopté par les professionnelles de santé obéit alors à des représentations profanes. Dans un cas comme dans l’autre, ce qui est marquant est que la sexualité est abordée par le biais de normes, mais qui ne sont pas de même nature – normes médicales et professionnelles dans le cas de la contraception et du dépistage, et normes profanes dans le cas de la sexologie. Mais quelle que soit leur nature, elles viennent en définitive renforcer les normes de genre et de sexualité dominantes dans la société.
Qu’est-ce qu’une homosexualité respectable ?
Authors: Tissot Sylvie 
Published: July 2022

Quels sont les critères de la respectabilité exigée des gays et des lesbiennes dans les espaces où ils et elles sont particulièrement intégré·e·s ? Reposant sur une enquête menée dans deux quartiers de Paris et New York, cet article montre que la mise à distance de la sexualité joue un rôle central dans la ville étasunienne, où l’homosexualité familiale fait, par ailleurs, l’objet d’une célébration et d’une surveillance intenses. Si les gays et les lesbiennes mariés gagnent en respectabilité dans les deux pays, l’esprit revendicatif est peu apprécié dans la capitale française, tout particulièrement pour ce qui concerne les lesbiennes. Les classements qui désignent, à travers la question de l’apparence notamment, celles que l’on accepte maintiennent une forte suspicion. En revanche, les stigmates attachés à l’homosexualité masculine, comme la « féminité », peuvent s’atténuer quand ils sont associés, aux yeux des hétérosexuel·le·s des classes moyennes et supérieures, à la détention d’un capital culturel.
La politique des broderies
Authors: Somda Dominique 
Published: July 2022

L’article explore la production d’une féminité luthérienne à travers les pratiques textiles de femmes du sud de Madagascar et de missionnaires norvégiennes-américaines, menées au sein des associations charitables, les « ladies aids », et dans les sections ménagères des « asyl vavy », pensionnats pour jeunes filles. Le projet missionnaire fut d’emblée marqué par sa combinaison ambiguë de progressisme et de conservatisme et le contexte inégalitaire de sa mise en œuvre. Les transferts de techniques et des biens ont produit des effets contrastés. La présence missionnaire dans les communautés luthériennes renforça l’inscription ethnique et nationale de la féminité des missionnaires nord-américaines, mais conduisit les femmes du sud de Madagascar à mettre les ancêtres à distance.
Weak complexation of 5-fluorouracil with β-cyclodextrin, carbonate, and dianhydride crosslinked β-cyclodextrin
Authors: Mashaqbeh Hadeia , Obaidat Rana , Al-Shar’i Nizar A. , El-Elimat Tamam , Alnabulsi Soraya 
Published: July 2022

Background and purpose:
Several pharmaceutical formulations were investigated to improve the solubility of 5-fluorouracil to enhance bioavailability and therapeutic efficacy. This study aimed to examine the potential use of cyclodextrin-based nanosponges for the incorporation of 5-fluorouracil and to investigate the use of different crosslinking agents on the properties of the resulting drug carrier. 5-Fluorouracil complexation with β-cyclodextrin was also studied to explain the unexpected results of weak 5-fluorouracil incorporation in nanosponge.

Experimental approach:
Nanosponges were synthesized by crosslinking β-cyclodextrin with two different crosslinkers; diphenyl carbonate and ethylenediaminetetraacetic dianhydride. The incorporation of 5-fluorouracil into β-cyclodextrin and the prepared nanosponges were assessed by NMR, FTIR, PXRD, DSC, and TGA. In addition, an in vitro release study was carried out to evaluate the potential use of β-cyclodextrin- based nanosponges as pharmaceutical formulations for 5-fluorouracil.

Findings / Results:
Physicochemical characterization of the dried formulations indicated the complexation of 5-fluorouracil with the β-cyclodextrin polymer. Despite that, no clear manifestation of 5-fluorouracil encapsulation in the prepared β-cyclodextrin-based nanosponge was detected. Furthermore, no significant differences were observed in the release profiles of 5-fluorouracil, β-cyclodextrin complex, and β- cyclodextrin-based nanosponge, suggesting weak complexation and instability in aqueous solutions. EDTA- crosslinked β-cyclodextrin-based nanosponge showed a slight improvement in 5-fluorouracil solubility with a faster initial rate of 5-fluorouracil release.

Conclusion and implications:
This study suggested weak complexation between 5-fluorouracil and the β- cyclodextrin polymer or nanosponges. Crosslinking of β-cyclodextrin with EDTA dianhydride crosslinker showed an enhancement in 5-fluorouracil saturation solubility combined with a faster initial rate of drug release.
Salvia officinalis leaf extracts protect against acute colitis in rats
Authors: Jalalipour Maryam , Yegdaneh Afsaneh , Talebi Ardeshir , Minaiyan Mohsen 
Published: July 2022

Background and purpose:
Inflammatory bowel disease (IBD) is a chronic and multifactorial disease with unknown etiology and a decisive cure. Salvia officinalis (sage) which has anti-inflammatory, anti-oxidative, and ulcer healing properties can be useful for the treatment of IBD. Therefore, the effect of S. officinalis ethanolic extract (SOEE) and methanolic partition (SOMP) was investigated on acetic acid-induced ulcerative colitis.

Experimental approach:
Male Wistar rats (180-220 g) were used. SOEE (30, 60, and 120 mg/kg) and SOMP (50, 100, and 150 mg/kg) were prepared through maceration method. Prepared extracts, dexamethasone (1 mg/kg, i.p.), and mesalamine (100 mg/kg) as reference drugs and normal saline as control were administered by gavage, 2 h before colitis induction and preserved for four further days to animals. The colon tissues were examined for macroscopic and pathologic parameters and myeloperoxidase (MPO) and malondialdehyde (MDA) levels.

Findings/Results:
SOEE (60 and 120 mg/kg) and SOMP at all doses alleviated colitis severity and indices both in macroscopic and microscopic views. MDA and MPO activities were also significantly declined in the extracts-treated groups compared to the controls. The lowest dose of SOEE couldn’t meaningfully reduce any of the parameters compared to the control group.

Conclusion and implications:
Both extracts of S. officinalis exerted anti-colitis effects in rats, though methanolic partition was more effective, especially at the highest dose. It seems S. officinalis could exert protection against oxidative stress and inflammatory mediators in colitis tissue. More experimental and clinical studies are required to explore the exact mechanisms and active ingredients which are involved.
Harmine mitigates cisplatin-induced renal injury in male mice through antioxidant, anti-inflammatory, and anti-apoptosis effects
Authors: Ghanbari Ali , Jalili Cyrus , Salahshoor Mohammad Reza , Javanmardy Setareh , Ravankhah Saeed , Akhshi Nasim 
Published: July 2022

Background and purpose:
Cisplatin is a chemotherapeutic drug used to treat cancer, however, causes kidney toxicity. Harmine is a plant-derived alkaloid with a wide range of therapeutic applications. The effects of harmine on the renal side effects of cisplatin in mice were studied in this study.

Experimental approach:
Forty-eight male BALB/c mice were randomly divided into eight groups (n = 6). They were treated with saline, cisplatin (5.5 mg/kg), harmine (5, 10, and 15 mg/kg/day), cisplatin + harmine (5, 10, and 15 mg/kg/day), respectively. All administrations were done daily and intraperitoneally for 4 days. The criteria related to histology, oxidation, anti-oxidation, inflammation, and apoptosis of renal tissue were evaluated.

Findings / Results:
There was a significant decrease in total antioxidant capacity of renal tissue, renal corpuscles diameter, and IL-10 expression level in the cisplatin group than in the control group, while the values of these parameters were significantly similar to the control group in the moderate or high doses of harmine + cisplatin groups. There were significant increases in serum urea and creatinine levels, bowman space, the amounts of malondialdehyde, apoptosis rate, and TNF-α, NF-κB, IL-1β, and caspase-3 gene expressions in kidney tissue of the cisplatin group compared to the control group, while these criteria did not differ in the moderate or high doses of harmine + cisplatin groups.

Conclusion and implications:
Harmine protected the kidneys against cisplatin-induced damage. Antioxidant, anti-inflammatory, and anti-apoptotic harmine properties were involved in this healing effect.
Application of three-dimensional reconstruction technology combined with three-dimensional printing in the treatment of pectus excavatum
Authors: Shan Yibo , Yu Guiping , Lu Yi , Kong Hao , Jiang Xuewei , Shen Zhiming , Sun Fei , Shi Hongcan 
Published: July 2022

OBJECTIVES:
To explore the clinical value of three-dimensional (3D) reconstruction technology combined with 3D printing in the treatment of pectus excavatum (PE).

METHODS:
The clinical data of 10 patients with PE in our department from June 2018 to December 2020 were analyzed retrospectively. All patients underwent thin-layer computed tomography examination before the operation, and then 3D reconstruction was performed with Mimics 20.0 software. The radian and curvature of the pectus bar were designed according to the reconstructed images. Afterward, the images were imported into the light-curing 3D printer in STL format for slice printing. Hence that the personalized operation scheme, including the size of the pectus bar and the surgical approach, can be made according to the 3D printed model. The thoracoscopic-assisted Nuss operation was completed by bilateral incisions. The operation time, intraoperative blood loss, and postoperative hospitalization were counted and analyzed. The satisfaction of the surgery was evaluated according to the Haller index and the most posterior sternal compression sternovertebral distance.

RESULTS:
The surgeries were successfully completed in 10 patients without a transfer to open procedure. The average operation time was (56 ± 8.76) min, the intraoperative blood loss was (23.5 ± 11.07) mL, and the postoperative hospitalization was (7.2 ± 0.92) d. There were no serious complications or death during the perioperative period. Compared with the data before the operation, the most posterior sternal compression sternovertebral distance was larger, and the Haller index was lower, the differences were statistically significant (P < 0.05).

CONCLUSIONS:
3D reconstruction technology combined with 3D printing, which can be used before operation, contributes to the operator performing thoracoscopic-assisted Nuss operation safely and effectively, which has productive clinical application value for the treatment of pectus excavatum.