bluuebunny/crossref_metadata_2025_split huggingface dataset:
Навчання та побут студентів Київської духовної семінарії (1947-1960 рр.)
Authors: Olitskyi Viacheslav 
Published: August 2022

Мета статті – дослідити навчальний процес і повсякденне життя вихованців Київської духовної семінарії у 1947-1960 рр.
Наукова новизна: охарактеризовано загальні риси навчального процесу, побутові умови та повсякденне життя студентів Київської духовної семінарії. Визначено розпорядок дня семінаристів і головні типи проведення позанавчального та вільного часу. Зроблено спробу аналізу впливу побутових умов семінарії, зокрема забезпечення житловими та навчальними площами на функціонування та розвиток закладу.
Висновки. У статті розкрито процес відкриття Київської духовної семінарії та вирішення проблеми забезпечення її належним приміщенням. Зосереджено увагу на модернізації приміщень. Окрему увагу приділено гуртожитку семінарії, як місцю, де вихованці проводили значну частину часу. Визначено умови проживання, житлові та навчальні площі, забезпеченість необхідними матеріалами, умови та правила проживання. Встановлено, яким чином нестача житлової площі впливала на функціонування та розвиток Київської духовної семінарії. Висвітлено правила внутрішнього розпорядку семінарії та режим дня студентів.
Окреслено особливості навчання у семінарії. Проаналізовано навчальне навантаження та дисципліни, які викладалися, склад педагогічного колективу. Показано правила поведінки семінаристів під час занять, самопідготовки, відвідування богослужінь, проживання у гуртожитку, під час споживання їжі. Встановлено шляхи вирішення проблеми із забезпеченням навчальним матеріалом.
Зосереджено увагу на повсякденні семінаристів. Розглянуто раціон харчування, матеріальне забезпечення, відпочинок і проведення вільного часу. Окреслено спроби ідеологічного впливу радянського тоталітаризму на майбутнє духовенство. Проаналізовано, які доповіді та лекції радянськими пропагандистами читалися у семінарії. Визначено завдання, методи та шляхи впливу радянських спецслужб на вихованців семінарії. Окремо у статті висвітлюється форми та методи висловлення семінаристами незгоди із діями адміністрації.
Encapsulated vaterite-calcite CaCO3 particles loaded with Mg2+ and Cu2+ ions with sustained release promoting osteogenesis and angiogenesis
Authors: Fan Lu , Körte Fabian , Rudt Alexander , Jung Ole , Burkhardt Claus , Barbeck Mike , Xiong Xin 
Published: August 2022

Bioactive cations, including calcium, copper and magnesium, have shown the potential to become the alternative to protein growth factor-based therapeutics for bone healing. Ion substitutions are less costly, more stable, and more effective at low concentrations. Although they have been shown to be effective in providing bone grafts with more biological functions, the precise control of ion release kinetics is still a challenge. Moreover, the synergistic effect of three or more metal ions on bone regeneration has rarely been studied. In this study, vaterite-calcite CaCO3 particles were loaded with copper (Cu2+) and magnesium (Mg2+). The polyelectrolyte multilayer (PEM) was deposited on CaCuMg-CO3 particles via layer-by-layer technique to further improve the stability and biocompatibility of the particles and to enable controlled release of multiple metal ions. The PEM coated microcapsules were successfully combined with collagen at the outmost layer, providing a further stimulating microenvironment for bone regeneration. The in vitro release studies showed remarkably stable release of Cu2+ in 2 months without initial burst release. Mg2+ was released in relatively low concentration in the first 7 days. Cell culture studies showed that CaCuMg-PEM-Col microcapsules stimulated cell proliferation, extracellular maturation and mineralization more effectively than blank control and other microcapsules without collagen adsorption (Ca-PEM, CaCu-PEM, CaMg-PEM, CaCuMg-PEM). In addition, the CaCuMg-PEM-Col microcapsules showed positive effects on osteogenesis and angiogenesis in gene expression studies. The results indicate that such a functional and controllable delivery system of multiple bioactive ions might be a safer, simpler and more efficient alternative of protein growth factor-based therapeutics for bone regeneration. It also provides an effective method for functionalizing bone grafts for bone tissue engineering.
Association of Early and Supernormal Vascular Aging categories with cardiovascular disease in the Chinese population
Authors: Cao Qiuyu , Li Mian , Wang Tiange , Chen Yuhong , Dai Meng , Zhang Di , Xu Yu , Xu Min , Lu Jieli , Wang Weiqing , Ning Guang , Bi Yufang , Zhao Zhiyun 
Published: August 2022

BackgroundEarly Vascular Aging and Supernormal Vascular Aging are two extreme phenotypes of vascular aging, and people in the two categories demonstrate distinct clinical characteristics and cardiovascular prognosis. However, the clinical implication of vascular aging categories in the Asian or Chinese population has not been investigated. We aimed to investigate the association between vascular aging categories and cardiovascular events in a Chinese cohort.MethodsWe explored the association of vascular aging categories with incident cardiovascular disease in a community cohort in Shanghai, China, which included 10,375 participants following up for 4.5 years. Vascular age was predicted by a multivariable linear regression model including classical risk factors and brachial-ankle pulse wave velocity. Early and Supernormal vascular aging groups were defined by 10% and 90% percentiles of Δ-age, which was calculated as chronological minus vascular age.ResultsWe found that cardiovascular risk significantly increased in Early [hazard ratio (HR), 1.597 (95% CI, 1.043–2.445)] and decreased in Supernormal [HR, 0.729 (95% CI, 0.539–0.986)] vascular aging individuals, comparing with normal vascular aging subjects. The associations were independent of the Framingham risk score. Early vascular aging individuals also showed an elevated risk of total mortality [HR, 2.614 (95% CI, 1.302–5.249)]. Further, the associations of vascular aging categories with cardiovascular risk were much stronger in females than in males. Vascular aging categories with different cutoff levels expressed as percentiles (10th, 20th, and 25th) of Δ-age showed similar associations with cardiovascular risk.ConclusionsIn conclusion, the vascular aging categories could identify people with different levels of cardiovascular risk in the Chinese population, particularly in women.
Clinical implications of central blood pressure measured by radial tonometry and automated office blood pressure measured using automatic devices in cardiovascular diseases
Authors: Kwon Ami , Kim Gee-Hee , Kim Min-Sik 
Published: August 2022

ObjectiveCentral aortic systolic blood pressure (CBP) measured by carotid-femoral pulse wave analysis (cfPWA) is a gold standard method to estimate true arterial pressure. However, the impact of the CBP level measured by radial PWA on cardiovascular (CV) risk assessment is unclear. This study aimed to determine the impact on CV outcome assessment and the association between the optimal levels of non-invasively measured CBP and automated office blood pressure (OBP) in clinical practice.Materials and methodsA total of 2,115 patients underwent non-invasive semiautomated radial artery applanation tonometry (Omron HEM-9000AI) in the Department of Internal Medicine, St. Vincent’s Hospital, from July 2011 to December 2015. The patients were followed for at least 5 years, and atherosclerotic cardiovascular (ASCVD) outcomes were collected.ResultsAmong 2,115 patients (mean age 58 ± 14 years, 50.4% men) who were followed up, the median follow-up period was 52 months (range: 1–104 months). The total number of patients with ASCVD events was 163 (7.70%). In multivariate Cox regression analysis, a CBP of more than 125 mmHg and an automated OBP of more than 131 mmHg were independently associated with a significant increase in ASCVD outcomes. After adjusting for confounding factors, the hazard ratio for ASCVD events increased by 12.5, 11.7, and 12.7%, for every 10 mmHg increase in automated OBP, CBP, and central pulse pressure (PP), respectively.ConclusionThis study demonstrated that the automated OBP measured using the method used in real clinical practice and CBP measured by radial tonometry were associated with an increased risk for adverse ASCVD outcomes.
Preoperative myocardial fibrosis is associated with worse survival after alcohol septal ablation in patients with hypertrophic obstructive cardiomyopathy: A delayed enhanced cardiac magnetic resonance study
Authors: Chen Youzhou , Zhao Xingshan , Yuan Jiansong , Zhang Yan , Liu Wei , Qiao Shubin 
Published: August 2022

BackgroundPrior studies have shown that myocardial fibrosis can be detected by late gadolinium enhancement (LGE) of cardiac magnetic resonance (CMR) and might be associated with higher mortality risk in hypertrophic cardiomyopathy (HCM). The objective of this study was to examine the prognostic utility of CMR in patients with hypertrophic obstructive cardiomyopathy (HOCM) undergoing alcohol septal ablation (ASA).Materials and methodsWe conducted a retrospective study which consisted of 183 consecutive patients with symptomatic drug-refractory HOCM who underwent CMR for assessment of myocardial fibrosis before ASA. The cardiovascular disease related survival was evaluated according to LGE-CMR status.ResultsThe cohort comprised 74 (40.4%) women with a mean age of 51 ± 8 years. Preoperative myocardial fibrosis was detected in 148 (80.9%) patients. After a median of 6 years (range 2–11 years) follow-up, adverse clinical events occurred in 14 (7.7%) patients. Multivariate-adjusted Cox regression analyses revealed that age [hazard ratio (HR) 1.142 (1.059–1.230), p = 0.001] and LGE [HR 1.170 (1.074–1.275), p &lt; 0.001] were independent predictors of cardiovascular mortality during follow-up.ConclusionPreoperative myocardial fibrosis measured by LGE-CMR was an independent predictor of increased adverse clinical outcomes in patients with HOCM undergoing ASA and could be used for the pre-operative evaluation of risk stratification and long-term prognosis after ASA in these patients.
Prolonged dual antiplatelet therapy after drug-eluting stent implantation in patients with diabetes mellitus: A nationwide retrospective cohort study
Authors: Lee Seung-Jun , Choi Dong-Woo , Kim Choongki , Suh Yongsung , Hong Sung-Jin , Ahn Chul-Min , Kim Jung-Sun , Kim Byeong-Keuk , Ko Young-Guk , Choi Donghoon , Park Eun-Cheol , Jang Yangsoo , Nam Chung-Mo , Hong Myeong-Ki 
Published: August 2022

BackgroundOptimal duration of dual antiplatelet therapy (DAPT) in patients with diabetes mellitus (DM) who have undergone drug-eluting stent (DES) implantation is not clearly established. This study sought to impact of DAPT duration on real-world clinical outcome in patients with or without DM.MethodsUsing a nationwide cohort database, we investigate the association between DAPT duration and clinical outcome between 1 and 3 years after percutaneous coronary intervention (PCI). Primary outcome was all-cause death. Secondary outcomes were cardiovascular death, myocardial infarction, and composite bleeding events. After weighting, 90,100 DES-treated patients were included; 29,544 patients with DM and 60,556 without DM; 31,233 patients with standard DAPT (6–12 months) and 58,867 with prolonged DAPT (12–24 months).ResultsThe incidence of all-cause death was significantly lower in patients with prolonged DAPT [8.3% vs. 10.5% in those with standard DAPT, hazard ratio (HR) 0.78, 95% confidence interval (CI) 0.72–0.84] in diabetic patients and non-diabetic patients (4.5% vs. 5.0% in those with standard DAPT, HR 0.89, 95% CI 0.83–0.96). The incidence of composite bleeding events was 5.7% vs. 5.4%, respectively, (HR 1.07, 95% CI 0.96–1.18) in diabetic patients and 5.6% vs. 5.0%, respectively, in non-diabetic patients (HR 1.13, 95% CI 1.05–1.21). There was a significant interaction between the presence of DM and DAPT duration for all-cause death (p for interaction, pint = 0.01) that further favored prolonged DAPT in diabetic patients. However, there was no significant interaction between the presence of DM and DAPT duration for composite bleeding events (pint = 0.38).ConclusionsThis study showed that prolonged rather than standard DAPT might be clinically beneficial in diabetic patients with DES implantation.Trial registrationClinicalTrial.gov (NCT04715594).
Drought variability and land degradation in the Amazon River basin
Authors: Paredes-Trejo Franklin , Barbosa Humberto , Giovannettone Jason , Kumar T. V. Lakshmi , Kumar Thakur Manoj , de Oliveira Buriti Catarina 
Published: August 2022

The Amazon River Basin (ARB) plays an essential role in global climate regulation. Recent studies have revealed signs of increasing drought conditions in different parts of the basin. Although human activities have degraded large areas, little work has been done to assess whether prolonged drought may exacerbate land degradation. Among different methods for monitoring land degradation, the Sustainable Development Goal (SDG) indicator 15.3.1 adopted by the United Nations Convention to Combat Desertification (UNCCD) allows a comprehensive assessment of the impacts of land degradation due to its multi-factor nature and scalability. The aims of this study are twofold: 1) to assess the status of land degradation using the SDG indicator 15.3.1 from 2001 to 2020 in the Amazon basin; and 2) to explore the relationship between the detectability of land degradation using the UNCCD approach and long-term drought severity. The Standardized Precipitation Index (SPI), Standardized Precipitation-Evapotranspiration Index (SPEI), and self-calibrating Palmer Drought Severity Index (scPDSI) were used as drought indices. The results revealed 757,704 km2 (12.67% of the basin) as degraded land, which was reflected by a downward trend in land productivity dynamics followed by the combined downward trend in land productivity, Soil Organic Carbon (SOC) degradation, and land cover degradation. The largest land degradation hotspot was identified along the southwestern boundary of the Amazon River Basin. Furthermore, there was strong evidence that the detection of land degradation through SDG indicator 15.3.1 is sensitive to long-term drought, particularly when applied to rainfed croplands.
The pharmacokinetic and pharmacodynamic properties and short-term outcome of a novel once-weekly PEGylated recombinant human growth hormone for children with growth hormone deficiency
Authors: Liang Yan , Zhang Cai , Wei Haiyan , Du Hongwei , Zhang Gaixiu , Yang Yu , Zhang Hua , Gong Haihong , Li Pin , Song Fuying , Xu Zhuangjian , He Ruoyi , Zhou Weidong , Zheng Heng , Sun Li , Luo Xiaoping 
Published: August 2022

ObjectivesTo investigate the pharmacokinetics (PK) and pharmacodynamics (PD) of Y-shape branched PEGylated recombinant human growth hormone (YPEG-rhGH) and evaluate its short-term efficacy and safety in children with growth hormone deficiency (GHD).MethodsA total of 43 children with GHD from 12 sites in China were enrolled in this randomized, multicenter, active-controlled, double-blind (YPEG-rhGH doses) trial. Patients were randomized 1:1:1:1 to 100, 120, and 140 μg/kg/week of YPEG-rhGH groups and daily rhGH 35 μg/kg/day groups. The treatment lasted 12 weeks. The primary outcome was the area under the curve of the change of insulin-like growth factor-1 (IGF-1). The secondary outcome was the height velocity (HV) increment at week 12.ResultsA dose-dependent response of maximum plasma concentration (Cmax) and area under the concentration-time curves from 0 to 168 hours (AUC0-168h) were observed for YPEG-rhGH. The ratio of Cmax and the ratio of AUC0-168h from the first to the last dosing were 1.09~1.11 and 1.22~1.26 respectively. A YPEG-rhGH dose-dependent increase in area under effect curve (AUEC) of IGF-1 fold change was observed. Model-derived mean IGF-1 SDS was in the normal range for all three YPEG-rhGH doses. At week 12, HV was 7.07, 10.39, 12.27 cm/year, and 11.58 cm/year for YPEG-rhGH 100, 120, and 140 μg/kg/week and daily rhGH respectively. Adherence and safety were consistent with the profile of daily rhGH. No related serious adverse events were reported.ConclusionThe PK/PD suggests that YPEG-rhGH is suitable for the once-weekly treatment of pediatric GHD. YPEG-rhGH 120 ~ 140 μg/kg/week provides the closest HV increment with similar safety and tolerability compared to daily rhGH 35 μg/kg/day in children with GHD.Clinical Trial RegistrationClinicalTrials.gov, identifier [NCT04513171].
How digital transformation improves corporate environmental management: A review and research agenda
Authors: Xia Jiahui , Wu Zhanchi , Chen Binhai 
Published: August 2022

Digital technologies offer opportunities and challenges for corporate environmental management (CEM). In this paper, we provide an overview of the literature on the relationship between digital transformation (DT) and CEM using a systematic review approach in the Antecedents, Decisions, and Outcomes (ADO) format. We review 181 papers published in almost 30 years from 1997 to 2022 and identify studies and areas where DT has impacted on CEM. We find that the literature examining the DT-CEM relationship has surged since 2019 and is concentrated in areas such as green sustainable science technology and environmental sciences. Further, we analyze the economic consequences of DT, the drivers of CEM, and the mechanisms of DT on CEM. Based on the literature analysis, we find that there is still a large gap in the literature studying the mediators and moderators of the DT-CEM relationship. Further, we find that firms with DT have better responsiveness and improved CEM by using digital resources to accurately capture the demands of different stakeholders on the environment. Finally, we provide a research framework and possible research directions, and propose corresponding management insights and policy recommendations.
Circulating microRNA: Myocardium-derived prenatal biomarker of ventricular septal defects
Authors: Yang Yiru , Yang Hainan , Lian Xihua , Yang Shuping , Shen Haolin , Wu Shufen , Wang Xiali , Lyu Guorong 
Published: August 2022

Background: Recently, circulating microRNAs (miRNAs) from maternal blood and amniotic fluid have been used as biomarkers for ventricular septal defect (VSD) diagnosis. However, whether circulating miRNAs are associated with fetal myocardium remains unknown.Methods: Dimethadione (DMO) induced a VSD rat model. The miRNA expression profiles of the myocardium, amniotic fluid and maternal serum were analyzed. Differentially expressed microRNAs (DE-microRNAs) were verified by qRT–PCR. The target gene of miR-1-3p was confirmed by dual luciferase reporter assays. Expression of amniotic fluid-derived DE-microRNAs was verified in clinical samples.Results: MiRNAs were differentially expressed in VSD fetal rats and might be involved in cardiomyocyte differentiation and apoptosis. MiR-1-3p, miR-1b and miR-293-5p were downregulated in the myocardium and upregulated in amniotic fluid/maternal serum. The expression of amniotic fluid-derived DE-microRNAs (miR-1-3p, miR-206 and miR-184) was verified in clinical samples. Dual luciferase reporter assays confirmed that miR-1-3p directly targeted SLC8A1/NCX1.Conclusion: MiR-1-3p, miR-1b and miR-293-5p are downregulated in VSD myocardium and upregulated in circulation and may be released into circulation by cardiomyocytes. MiR-1-3p targets SLC8A1/NCX1 and participates in myocardial apoptosis. MiR-1-3p upregulation in circulation is a direct and powerful indicator of fetal VSD and is expected to serve as a prenatal VSD diagnostic marker.
RNA-Seq Comprehensive Analysis Reveals the Long Noncoding RNA Expression Profile and Coexpressed mRNA in Adult Degenerative Scoliosis
Authors: Shi Xin , Li Panpan , Wu Xiang , Wang Zhihua , Zhao Gang , Shu Jun 
Published: August 2022

Objective: Owing to the intensification of the aging process worldwide, the prevalence of adult degenerative scoliosis (ADS) is increasing at an alarming rate. However, genomic research related to the etiology of ADS is rarely reported worldwide. Since long noncoding RNAs (lncRNAs) play a pivotal role in the progression of human diseases, this study aimed to investigate ADS-associated messenger RNAs (mRNAs) and lncRNAs by RNA sequencing (RNA-seq), as well as performed comprehensive bioinformatics analysis based on the lncRNA–mRNA coexpression network and protein–protein interaction (PPI) network.Methods: Initially, six whole blood (WB) samples were obtained from three ADS and three nondegenerative lumbar trauma patients who underwent surgical operation for RNA-seq exploration to construct differential mRNA and lncRNA expression profiles. Subsequently, quantitative RT-PCR (qRT-PCR) was performed to validate three randomly selected differentially expressed mRNAs and lncRNAs derived from the nucleus pulposus (NP) tissue of 14 other subjects (seven ADS patients and seven nondegenerative lumbar trauma patients), respectively.Results: A total of 1,651 upregulated and 1,524 downregulated mRNAs and 147 upregulated and 83 downregulated lncRNAs were screened out from the RNA-Seq data, which constructed coexpression networks to investigate their regulatory interactions further. GO gene function prediction revealed that lncRNA-targeted genes might play a vital role in ADS via participation in multiple biological processes such as the AMPK signaling pathway, lysosomes, and ubiquitin-mediated proteolysis, as well as cellular metabolic processes. Moreover, the expression levels of three selected lncRNAs and mRNAs were validated by qRT-PCR, respectively, demonstrating that the relative expression levels were consistent with the RNA-seq data. Notably, the dysregulated RNAs, AKT1, UBA52, PTPN12, and CLEC16A, were significantly differentially expressed in ADS WB samples and might serve as potentially regulated genes for research in the future.Conclusions: This study provides the first insight into the altered transcriptome profile of long-stranded noncoding RNAs associated with ADS, which paves the way for further exploration of the clinical biomarkers and molecular regulatory mechanisms for this poorly understood degenerative disease. However, the detailed biological mechanisms underlying these candidate lncRNAs in ADS necessitate further elucidation in future studies.