bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of 1% curcumin gel on myeloperoxidase activity in GCF and periodontal status in the initial phase of orthodontic tooth movement
Authors: Samita  , Verma Sanjeev K. , Sharma Vivek K. , Moinuddin  , Ahad Abdul 
Published: November 2022

AIM:
To explore the potential effect of locally applied 1% Curcumin on myeloperoxidase (MPO) enzymatic activity in gingival crevicular fluid (GCF) and on the periodontal status during the initial phase of orthodontic tooth movement.

SETTINGS AND DESIGN:
Forty patients (26 females and 14 males) aged 12-25 years who required fixed orthodontic treatment were randomly divided into two equal groups. The control and test groups were similar in the various baseline parameters, including standard oral hygiene protocol. Moreover, 1% Curcumin gel was applied around mandibular anterior teeth in the test group twice daily, from three days before to 14 days after the placement of archwires. MPO activity and periodontal status were recorded at five different time points; before placement of archwire (baseline), immediately after placement of archwire, 2 hours, 7 days, and 14 days later.

STATISTICAL ANALYSIS USED:
The data were analyzed using the paired t-test for intra-group differences and the unpaired t-test for intergroup differences at five different time points. Statistical significance in the intragroup and intergroup difference of Plaque and Gingival index was calculated using the unpaired t-test.

RESULTS:
Maximum MPO enzymatic activity in GCF was observed two hours after the placement of the archwire. MPO activity decreased slightly on the seventh day, but values were still elevated as compared to baseline. However, MPO activity came back to the values similar to baseline on day 14 in the control group and significantly lower than the baseline in the test group. The inter-group differences in clinical periodontal parameters were non-significant.

CONCLUSIONS:
The locally applied 1% Curcumin gel appears to decrease the MPO activity in GCF on the 14th day after placement of the archwires. However, clinical periodontal status in the initial phase of tooth movement is unaffected by curcumin if patients adhere to good plaque control.
Zebrafish as model for studies in dentistry
Authors: Ohashi Amanda S. C. , de Souza Schacher Helena R. , Pizzato Christiane S. , Vianna Mônica R. M. R. , de Menezes Luciane M. 
Published: November 2022

INTRODUCTION:
Over the last years, zebrafish has gained prominence in the biomedical community. It is currently considered one of the best vertebrate animal models for various types of studies, such as toxicology and developmental biology.

OBJECTIVE:
The aim of this study was to conduct a literature review on the use of zebrafish in dentistry and whether this animal model could be a viable alternative for performing different types of studies in this area.

METHODS:
A literature search was performed using the PubMed, Lilacs, Embase, and Dentistry and Oral Sciences Source. The keywords used as search terms were zebrafish and dentistry. The selection criteria were articles published in English that used zebrafish as an animal model in dentistry, oral health, and craniofacial growth/development.

RESULTS:
The electronic search of literature yielded 421 articles. After the analysis of the abstracts, 29 articles were selected for an in-depth analysis and reading of the full text.

CONCLUSIONS:
All studies included in this review confirm zebrafish's excellence as an animal model for various types of dentistry studies, as well as assisting and complementing other studies involving mammals.
The influence of obstructive sleep apnea on self-perceived dental aesthetics and need for orthodontic treatment among the general population in Makkah, Saudi Arabia
Authors: Alotaibi Shahad Dh. , Alotaibi Amjad S. , Barashi Mohammed A. , Khojah Maysaa Z. , Rajeh Mona T. 
Published: November 2022

OBJECTIVE:
To assess the influence of obstructive sleep apnea on self-perceived dental appearance and need for orthodontic treatment.

MATERIALS AND METHODS:
A self-administered questionnaire was used in a random sample of a general adult population in Makkah region, Saudi Arabia. A total of 1014 participants completed the questionnaires, which included the STOP-BANG questionnaire, Oral Aesthetics Subjective Impact Score questionnaire, and Aesthetic Component of Index of Orthodontic Treatment Need questionnaire. Descriptive statistics and Chi-square tests were used to compare differences between the groups.

RESULTS:
Overall, 6.5% (66/1014) of the participants were classified as being at high risk of OSA of which 71.2% were males and 28.8% were females (P < 0.001), 57.6% were >50 years of age, 90.9% had obesity, and 81.8% had an enlarged neck circumference. But only 10.1% of the participants reported that they snore loudly. A positive self-perception of dental esthetics was found in 42 (6.2%) and 518 (76.6%) participants at high and low risk of OSA, respectively. Furthermore, of the participants in the high- and low-risk groups, 4.2% and 66.7% considered themselves in need of orthodontic treatment, respectively.

CONCLUSIONS:
The prevalence rate of people at intermediate to high risk of OSA was 26% of the general population and being at high risk of OSA had no influence on self-perceived dental esthetics and need for orthodontic treatment.
BIST Bilişim Sektöründe Faaliyet Gösteren İşletmelerin Finansal Performanslarının Nakit Akış Oranları Kapsamında CRITIC Temelli TOPSIS Yöntemi ile Değerlendirilmesi
Authors: SAKARYA Şakir , İLKDOĞAN Sena 
Published: November 2022

Bu çalışmada, BIST Bilişim sektöründe faaliyet gösteren işletmelerin 2017-2021 yılları arasındaki finansal
performanslarının nakit akış tablosuna dayalı oranlarla analizi amaçlanmıştır. Bunun için seçilen oranlar,
objektif bir yöntem olan CRITIC yöntemi ile ağırlıklandırılmıştır. Şirketlerin finansal performanslarının değerlendirilmesinde çok kriterli karar verme yöntemlerinden biri olan TOPSIS yönteminden yararlanılmıştır. Analiz sonucunda; 2017 yılından 2021 yılına kadar en başarılı işletmelerin sırasıyla KRONT,
LINK, LINK, INDES ve LINK olduğu görülmüştür. Finansal performans açısından en başarısız işletmelerin
ise sırasıyla DESPC, NETAS, DGATE, DESPC ve NETAS olduğu tespit edilmiştir.
Multiple hamartomas of the oral cavity with bifid tongue and cleft palate: A unique observation
Authors: Hassan Moaied 
Published: November 2022

Background: Hamartomas are developmental tumor-like malformations, comprising a mixture of cytologically mature tissues that are indigenous to their anatomical location. Within the oral cavity, these lesions are usually multifocal, relatively small, and asymptomatic, and have been frequently linked to present as a manifestation of the oro-facial-digital-syndrome.
Case Presentation: A 2-day-old female newborn was referred with two masses protruding from the oral cavity, feeding difficulties, and dribbling of milk during feeding. The patient had no dysmorphic features and no obvious associated anomalies. On careful examination, there was one mass protruding from the undersurface of a bifid tongue with another larger mass that seemed to originate from the hard palate. Complete surgical excision of both masses and repair of the bifid tongue were done to relieve the baby’s feeding difficulties. Histopathological examination of both specimens confirmed the diagnosis of multiple hamartomas.
Conclusion: The occurrence of multiple and large oral hamartomas in newborns might result in feeding difficulties that necessitate urgent surgical intervention. The association of lingual and palatal hamartomas, with bifid tongue and cleft palate, is a unique observation that is not reported in the English literature.
ON THE BASIS OF PERCEPTION: A MODERATED MEDIATION ANALYSIS OF DOING BUSINESS AND CORRUPTION
Authors: Dahlan Muhammad 
Published: November 2022

One of the landmark projects from the World Bank was the initiative called the Ease of Doing Business (EODB), which captures business regulatory settings in countries worldwide. The EODB scores have long indicated a country’s attractiveness in doing business with private sectors and have attracted many scholars, policymakers, and practitioners to explore. Many researchers have indicated that doing business scores were associated with economic growth, international relations, business development, and many other areas. This study contributes to the debate on how business regulations are associated with the perception of corruption index (CPI) using moderated mediation analysis. The results find that GDP per capita mediates the relationship between EODB and CPI and that country’s income category moderates the mediation. The relationships are explored for a period of ten years, from 2010 to 2019 worldwide (n= 146). The country’s income category moderated the mediating impact of GDP per capita by softening the influence of EODB on CPI ( .3013, BootSE = .0507, LLCI =0.2246, ULCI= 0.4226). The author suggests corroborating factor analysis and exploring the variables using more advanced path analysis for future research
An X-ray lead screen may be used to reduce an interventional radiologist’s radiation exposure during CT-guided procedures
Authors: Rosiak Grzegorz , Podgórska Joanna , Milczarek Krzysztof , Konecki Dariusz , Rowiński Olgierd 
Published: November 2022

IntroductionThe exposure of both patient and operator to radiation is one of the limitations of computed tomography (CT)-guided interventions, and it should be kept as low as reasonably possible. The purpose of the study was to evaluate the efficacy of a lead screen in reducing the radiation dose to an operator in the course of CT-guided interventions.Material and methodsThis prospective study analysed data collected from 72 consecutive CT-guided procedures, all of which were performed with an X-ray protective lead screen placed between the scanner and the operator. Five dosimeters were placed in the CT scanning room, and accumulated radiation doses were measured for each dosimeter.ResultsThe dosimeter placed on the gantry side of the lead screen revealed highest levels of radiation (11.33 ± 1.93 mSv),
which were significantly higher than those at all other dosimeters. The radiation dose behind the lead screen was almost the same when measured by dosimeters on the CT scanner gantry side and 3 metres away from it. The presence of the screen caused no discomfort for operators.ConclusionsA lead screen reduces an operator’s radiation exposure significantly, while not posing any obstacles or causing any discomfort while CT-guided procedures are carried out.
Peningkatan Keterampilan Membuat Karya Inovasi Media Pembelajaran melalui Metode Modifikasi Permainan Anak
Authors: Budiastuti Siti Arina 
Published: November 2022

Permasalahan dalam penelitian ini adalah rendahnya keterampilan guru dalam membuat media pembelajaran inovatif, sehingga berdampak pada terhambatnya kenaikan pangkat guru karena kurang dalam membuat karya inovasi. Tujuan penelitian untuk meningkatkan keterampilan guru membuat media pembelajaran inovatif dengan metode modifikasi permainan anak, dengan subyek 25 guru muda terdiri dari golongan III dan honorer. Penelitian dilakukan dalam 2 siklus masing-masing tiga pertemuan dan tiap siklus guru membuat satu media pembelajaran inovatif. Pada siklus I memodifikasi permainan anak yang sederhana kartu dan puzzle, selanjutnya pada siklus II memodifikasi yang lebih kompleks yaitu ular tangga, monopoli, engklek dan mystery box. Hasil penelitian menunjukan secara proses pada siklus I skor guru antara 81-94, dan pada siklus II memperoleh skor 86 – 99 dalam kategori baik, dan dari hasil unjuk kerja siklus I skor 81,25 - 90,60 (Baik), dan siklus II skor 87,50 - 96,88 (sangat baik), serta menunjukan peningkatan antara siklus I dan siklus II. Guru yang membuat media pembelajaran inovatif sebelum penelitian sebanyak 2 (3,33%) dari 60 guru, setelah penelitian bertambah 25 (41,67%), ini menunjukan bahwa metode modifikasi permainan anak dapat meningkatkan keterampilan guru dalam membuat media pembelajaran inovatif. Keterampilan guru meliputi berkomunikasi, berkolaborasi, berfikir kritis, berkreasi, kemandirian dan produktivitas untuk mewujudkan media pembelajaran yang inovatif.
Global seasonal distribution of CH2Br2 and CHBr3 in the upper troposphere and lower stratosphere
Authors: Jesswein Markus , Fernandez Rafael P. , Berná Lucas , Saiz-Lopez Alfonso , Grooß Jens-Uwe , Hossaini Ryan , Apel Eric C. , Hornbrook Rebecca S. , Atlas Elliot L. , Blake Donald R. , Montzka Stephen , Keber Timo , Schuck Tanja , Wagenhäuser Thomas , Engel Andreas 
Published: November 2022

Abstract. Bromine released from the decomposition of short-lived brominated source gases contributes as a sink of ozone in the lower stratosphere.
The two major contributors are CH2Br2 and CHBr3.
In this study, we investigate the global seasonal distribution of these two substances, based on four High Altitude and Long Range Research Aircraft (HALO) missions, the HIAPER Pole-to-Pole Observations (HIPPO) mission, and the Atmospheric Tomography (ATom) mission.
Observations of CH2Br2 in the free and upper troposphere indicate a pronounced seasonality in both hemispheres, with slightly larger mixing ratios in the Northern Hemisphere (NH).
Compared to CH2Br2, CHBr3 in these regions shows larger variability and less clear seasonality, presenting larger mixing ratios in winter and autumn in NH midlatitudes to high latitudes.
The lowermost stratosphere of SH and NH shows a very similar distribution of CH2Br2 in hemispheric spring with differences well below 0.1 ppt, while the differences in hemispheric autumn are much larger with substantially smaller values in the SH than in the NH.
This suggests that transport processes may be different in both hemispheric autumn seasons, which implies that the influx of tropospheric air (“flushing”) into the NH lowermost stratosphere is more efficient than in the SH.
The observations of CHBr3 support the suggestion, with a steeper vertical gradient in the upper troposphere and lower stratosphere in SH autumn than in NH autumn.
However, the SH database is insufficient to quantify this difference.
We further compare the observations to model estimates of TOMCAT (Toulouse Off-line Model of Chemistry And Transport) and CAM-Chem (Community Atmosphere Model with Chemistry, version 4), both using the same emission inventory of Ordóñez et al. (2012).
The pronounced tropospheric seasonality of CH2Br2 in the SH is not reproduced by the models,
presumably due to erroneous seasonal emissions or atmospheric photochemical decomposition efficiencies.
In contrast, model simulations of CHBr3 show a pronounced seasonality in both hemispheres, which is not confirmed by observations.
The distributions of both species in the lowermost stratosphere of the Northern and Southern hemispheres are overall well captured by the models with the exception of southern hemispheric autumn,
where both models present a bias that maximizes in the lowest 40 K above the tropopause, with considerably lower mixing ratios in the observations.
Thus, both models reproduce equivalent flushing in both hemispheres, which is not confirmed by the limited available observations.
Our study emphasizes the need for more extensive observations in the SH to fully understand the impact of CH2Br2 and CHBr3 on lowermost-stratospheric ozone loss and to help constrain emissions.
HUBUNGAN USIA DAN PARITAS IBU BERSALIN DENGAN KEJADIAN KPD
Authors: Netri Yulia 
Published: November 2022

The incidence of Early Rupture of Amniotic fluid (KPD) in Indonesia rangers from 4,5% to 7.,6% of all pregnancies, whereas in India it ranges from 6% to 12%. This number is a problem that is still not resolved, especially in developing countries. The incidence of KPD ranges from 3-18% that occurs in preterm pregnancies, whereas at term pregnancies around 8-10%, pregnant women come with the condition of the KPD, where 30-40% are preterm pregnancies at the Regional General Hospital which is the place of reference in Indonesia (Sulistyawati, 2014).
The aim of the study was to determine the relationship of age and parity of maternity with the incidence of premature rupture of membranes in Raden Mattaher General Hospital of Jambi Province in 2019.
The results showed an association between age with the incidence of premature rupture of membranes in Raden Mattaher Hospital Jambi Province p-value 0,009 and presence the relationship between parity and the incidence of premature rupture of membranes in Raden Mattaher General Hospital, Jambi Province, p-value 0,034. It is expected that the results of this study midwives can improve Antenatal Care services that are more qualified and able to detect risk factors in pregnant women to prevent the risk of occurrence of premature rupture of membranes such as reminding mothers of age and parity the risk of premature rupture of membranes.
PENGETAHUAN DAN MOTIVASI LANSIA TENTANG POSYANDU LANSIA
Authors: Lubis Sunarti 
Published: November 2022

Berdasarkan data dari Dinas Kesehatan Kota Jambi menunjukkan bahwa Puskesmas Simpang Kawat Kota Jambi mengalami penurunan yang sangat drastis dari kunjungan posyandu lansia, yaitu tahun 2011 kunjungan lansia lama sebanyak 556 lansia (100%). Sedangkan pada tahun 2018 kunjungan lansia sebanyak 144 lansia (8.86%).
Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional. Tempat penelitian dilakukan di Puskesmas Simpang Kawat Kota Jambi. Waktu penelitian telah dilaksanakan pada bulan Mei tahun 2019. Populasi dalam penelitian ini yaitu seluruh lansia yang bertempat tinggal di Wilayah Kerja Puskesmas Simpang Kawat Kota Jambi bulan Januari-Maret tahun 2019 sebanyak 139 orang. Sampel dipilih dengan teknik accidental sampling sebanyak 35 responden. Pengumpulan data dalam penelitian ini dengan teknik wawancara. Pengumpulan data dalam penelitian ini dengan menggunakan kuesioner. Analisis data dilakukan secara Univariat, yaitu menyederhanakan atau memudahkan intervensi data ke dalam bentuk penyajian diagram atau tabel.
Hasil penelitian menunjukkan sebagian besar responden memiliki pengetahuan kurang baik sebanyak 14 responden (40,0%) dan sebagian responden memiliki pengetahuan cukup sebanyak 12 responden (34,3%). Sebagian besar responden memiliki motivasi rendah sebanyak 22 responden (62,9%) dan sebagian responden memiliki motivasi tinggi sebanyak 13 responden (37,1%).
Hasil penelitian ini diharapkan agar petugas kesehatan memberikan penyuluhan dan informasi tentang posyandu lansia serta dengan mencanangkan suatu program posyandu lansia yang berada di wilayah kerjanya.
Factors in the development of refractory primary open-angle glaucoma (part 1)
Authors: Fomin N. E. , Kuroyedov A. V. 
Published: November 2022

Primary open-angle glaucoma (POAG) is one of the most significant medico-social problems in the modern society. The development of its refractoriness aggravates the pathological process and inevitably leads to blindness. Despite the fact that this form accounts for up to 80% of all glaucoma cases, the problem of POAG refractoriness has not been considered in sufficient detail in either Russian or foreign sources. The article presents an overview of the main ophthalmic factors that contribute to changes in various structures of the eyeball and accelerate the formation of refractory forms of POAG. One of the reasons for that is a genetic predisposition to the development of POAG. It is worth noting that in 60% of patients with a family history of glaucoma, the risk of developing POAG increases by 10 times (among the first-degree relatives).Additional factors in the development of the refractory form of POAG are the reactive syndrome and during laser surgery. It is important to emphasize that the risk of development and progression of POAG in patients with a hereditary predisposition is much higher, while indicating a number of therapeutic measures may lead to drug resistance. Genotyping is a promising scientific and practical direction of research, allowing prediction of the pharmacological response to a particular drug and individual selection of the appropriate therapy according to the patient's genotype. This approach could help prevent a number of complications and improve the accuracy of disease prognosis.
Susceptibilidade de populações de Sitophilus zeamais ao óleo essencial de folhas de Croton pulegiodorus
Authors: Santos Patryck Érmerson Monteiro dos , Oliveira Carlos Romero Ferreira de , Matos Cláudia Helena Cysneiros 
Published: November 2022

O estudo teve como finalidade analisar a atividade fumigante do óleo essencial de folhas de Croton pulegiodorus sobre populações diferentes de Sitophilus zeamais oriundas das cidades de Crixás-GO, Espírito Santo do Pinhal-SP, Juiz de Fora-MG, Picos-PI, Serra Talhada-PE e Vicentina-MS. Para as populações estudadas, foram realizados experimentos para estimar as concentrações letais (CL50 e CL90), as razões de toxicidade e a razão de resistência ao óleo essencial de C. pulegiodorus. O óleo essencial apresentou potencial inseticida e as populações de S. zeamais avaliadas apresentaram diferentes níveis tolerância. As menores CL50 e CL90 foram apresentadas pela população de Picos-PI, e as maiores foram apresentadas por Serra Talhada-PE e Picos-PI. Para a razão de toxicidade foram observados valores de 1,06 a 1,71 para a CL50, e de 1,05 a 1,57 para a CL90. A razão de resistência variou entre 1,11 e 1,72. As CL50 e CL90 foram consideradas baixas quando comparadas às de outros óleos essenciais estudados sobre pragas de sementes e grãos, ratificando a possibilidade de seu uso no manejo de S. zeamais em milho armazenado.
Significados produzidos por estudantes do ensino médio sobre fenômeno das marés em aulas investigativas
Authors: Baptista Carla 
			Maria Fachini , Lawall Ivani 
			Teresinha , Clement Luiz 
Published: November 2022

Frente al desinterés que los estudiantes de Enseñanza Media presentan com relación a las disciplinas de Ciencias, en especial de Fisica, vemos acentuada la necesidad de la ampliación de los estúdios enfocados en el desarrollo y pruebas de estratégias y perspectivas de enseñanza diferentes de aquellas que comunmente son utilizadas por los profesores en clases (clases expositivas y poco dialogadas). Tomando en cuenta este escenario, desarrollamos una Secuencia de Enseñanza por Investigación (SEI) para abordar la gravitación y, en este artículo, objetivamos retratar como los estudiantes entienden y explican el fenómeno de las mareas, así como, si hubo producción o mudanza de significados relacionados a este tema, a lo largo de la implementación de la SEI. Los resultados retratados en el articulo fueron obtenidos a partir del análisis de la información recolectada mediante un Estudio Diagnóstico (ED) y a partir de la producción de los estudiantes a lo largo de la SEI (Preguntas de Apoyo y Cartas-Respuesta) La SEI fue implementada en una clase de primer año de Enseñanza Media de una escuela pública del estado de Santa Catarina. Los significados producidos por os estudiantes fueron evaluados a la luz de la teoría del Aprendizaje Significativo de David Ausubel. A partir del análisis de los registros de los estudiantes, que surgem de las actividades propuestas, constatamos que, en comparación al ED al cual fueron sometidos, las actividades investigativas que propusimos contribuyeron positivamente para la producción y modificación de significados relacionados al fenómeno de las mareas.