bluuebunny/crossref_metadata_2025_split huggingface dataset:
Duodenal diverticula perforation caused by an impacted bezoar successfully treated by endoscopic drainage and lithotripsy: A case report and literature review
Authors: Tadokoro Takeshi , Oishi Koichi , Namba Yosuke , Bekki Tomoaki , Okimoto Sho , Mukai Shoichiro , Saito Yasufumi , Fujisaki Seiji , Takahashi Mamoru , Mouri Teruo , Nishida Toshihiro , Fukuda Toshikatsu 
Published: November 2022

AbstractDuodenal diverticula perforation due to an impacted bezoar is a rare disease. Surgical treatment is associated with high rates of complications and mortality; therefore, treatment strategies must be carefully decided. Endoscopic treatment offers significant benefits to patients over surgery.
SLE‐associated myelitis successfully treated by rituximab
Authors: Khabbazi Alireza , Ghadakchi Leyla , Yazdani Yalda , Habibzade Elham , Mehrtabar Saba , Khalaji Amirreza 
Published: November 2022

AbstractSystemic lupus erythematosus (SLE) is an autoimmune disease. Transverse myelitis (TM) is one of the rare neurological manifestations of SLE. Here, we present a case of SLE in which TM precede other symptoms and successfully treated by Rituximab.
Cyst of rete ovarii: A case report
Authors: Jha Kritika , Aryal Roshan , Khaniya Bishal , Maskey Suvana , Ojha Neebha 
Published: November 2022

AbstractRete ovarii giving rise to cysts, and benign and malignant tumors is a rare entity. Radiological and histopathological examinations can be used to make the diagnosis of rete cyst and differentiate it from cystic tumor of ovarian origin, with surgery being the treatment of choice.
Retained tracheostomy stay suture with migration into the glottic airway: A case report
Authors: Johns J. Dixon , Habib Andy M. , Dixit Ronak B. 
Published: November 2022

AbstractThe stay‐suture technique (SST) helps ensure safe replacement of the tracheostomy tube after accidental decannulation. We describe a patient found to have a retained stay suture in the glottis 2 weeks post‐decannulation. It is important to appreciate the possible complications associated with SST, including airway compromise, infection, and laryngospasm.
Elevated troponin level and nonspecific ST‐segment and T‐wave changes in a suspected acute pancreatitis patient, post‐SARS‐Cov‐2 infection: A case report
Authors: Pourfridoni Mohammad , Khan Moien A. B. , Khalil‐Khan Alam , Mohammad Bagheri Rafsanjani Afshin , Askarpour Hedyeh 
Published: November 2022

AbstractThe case report describes a post‐COVID‐19 patient with severe right upper quadrant (RUQ) pain, moderate epigastric pain, high troponin levels, and nonspecific ST‐segment and T‐wave changes on electrocardiogram (ECG).
Simultaneous Organic Matter and Nitrogen Removal from Piggery Slaughterhouse Wastewater Using Bioaugmented Gaslift Membrane Bioreactor
Authors: Toan Nguyen Duc , Tuyen Nguyen Van , Hai Pham Bang , Ha Nguyen Thi Hoang , Anh Do Tien , Dung Bach Quang 
Published: November 2022

AbstractA single bioaugmentation reactor and a side‐stream gaslift membrane bioreactor combined with bioaugmentation are conducted to treat real wastewater from a centralized piggery slaughterhouse in Vietnam. The bioaugmented reactor is inoculated with heterotrophic microorganisms (Bacillus sp.) isolated from piggery slaughterhouse wastewater. The results of a single bioaugmentation experiment show high removal efficiency of chemical oxygen demand (COD) (84.8%–97.5%) and total nitrogen (TN) (69.9%–87.2%) at loading rates of 1.28–3.89 and 0.14–0.37 kg m−3 d−1, respectively. The combined system demonstrates a significantly higher TN removal efficiency (89.0%–96.1%) (p < 0.001), more stable flux (36.0–38.4 L m−2 h−1), and transmembrane pressure (0.95–1.05 bar), and better capacity of separation of solid–liquid phases compared to the single bioaugmentation. High COD and TN removal efficiency is possibly due to assimilation and simultaneous nitrification and denitrification processes. The results of this study also indicate the feasibility and propitious efficiency of the bioaugmented gaslift membrane bioreactor for piggery slaughterhouse wastewater treatment.
Effect of Futibatinib on Cardiac Repolarization: Results of a Randomized, Controlled, Double‐Blind, QT/QTc, Phase 1 Study in Healthy Subjects
Authors: Yamamiya Ikuo , Lester Robert , Sonnichsen Daryl , Mina Mark , He Yaohua , Benhadji Karim A. 
Published: November 2022

AbstractFutibatinib, a fibroblast growth factor receptor (FGFR) 1–4 inhibitor, is being investigated for FGFR‐aberrant tumors. A 4‐period, crossover, phase 1 thorough QT/QTc study compared effects on Fridericia heart rate–corrected QT (QTcF) interval of single doses of futibatinib 20 and 80 mg (therapeutic and supratherapeutic doses, respectively), placebo, and moxifloxacin (positive control) in healthy subjects. The study objective was to assess the time‐matched difference in change from baseline in QTcF (ddQTcF) between futibatinib and placebo. In addition, changes from baseline in QTcF and other electrocardiogram (ECG) parameters, pharmacokinetics, ECG morphology, and safety were assessed. Forty‐eight subjects were randomized. ddQTcF upper limits of 2‐sided 90%CIs remained <10 milliseconds (clinical threshold) for both futibatinib doses at all time points (range, 2.0–4.5 milliseconds). Assay sensitivity was demonstrated by lower limits of 2‐sided 97.5%CIs of the dQTcF difference between moxifloxacin and placebo of >5 milliseconds. Futibatinib exposure increased in a dose‐dependent manner, and no significant relationship was detected between plasma futibatinib concentration and ddQTcF. There were no significant effects on heart rate, other ECG parameters, or ECG morphology. No serious adverse events occurred. Futibatinib did not prolong QTcF or affect other cardiac measures at therapeutic or supratherapeutic doses.
DLPM: A dynamic location protection mechanism supporting continuous queries
Authors: Zhu Linghe , Hong Haibo , Xie Mande , Yu Jun 
Published: November 2022

SummaryCurrently, the protection of users' location privacy, particularly for moveable users, is a major concern for both academia and business. In order to receive required services, a moveable user needs to constantly disclose his/her location information with an untrusted third party in his/her locations, which raises security and privacy issues. To settle the above problems, in this work, we creatively integrate local differential privacy (LDP) with conditional random field (CRF) to facilitate continuous location sharing among moveable users. Firstly, we advance a novel approach of employing CRF to represent users' mobility. After that, we establish a system to provide continuous location sharing by combining the ‐location set and ‐LDP. Finally, we evaluate the system performance on actual data sets. The experimental results indicate that our technique outperforms the planar isotropic mechanism (PIM) and AGENT.
Phase‐shifted full‐bridge converter based on an adjustable current auxiliary circuit with full load range ZVS and small duty cycle loss
Authors: Gao Yahu , Tang Yu , Kan Jiarong , Shi Zhe , Liu Hongjing , Niu Jincai , Tian Donghao 
Published: November 2022

AbstractIn this paper, a phase‐shifted full‐bridge converter based on an adjustable current auxiliary circuit is proposed. The converter's switches achieve ZVS with the help of the parallel current provided by the auxiliary circuit. The conduction loss of the parallel current is reduced since the magnitude of the current can be adjusted by the variable inductor. Since there is no additional series inductor, the duty cycle loss of the proposed converter is minimal. Moreover, the oscillating voltage on the secondary side decays quickly, indicating that the energy involved in the oscillation is small, which is beneficial to reduce the loss of the RCD. The experimental platform is built. On this basis, theoretical analysis and experimental verification are carried out in this paper.
Preferences of NIA Alzheimer's Disease Research Center participants regarding remote assessment during the COVID‐19 pandemic
Authors: Nunnerley Michael , Mattek Nora , Kaye Jeffrey , Beattie Zachary 
Published: November 2022

AbstractIntroductionDuring the COVID‐19 pandemic, in‐person research study visits were moved to an online format using a variety of communication platforms (e.g., Webex and Zoom). Increased technology use among older adults allowed for greater insight regarding the remote research study visit format.MethodsA survey developed by the National Alzheimer's Coordinating Center (NACC) was distributed among 12 Alzheimer's Disease Research Centers (ADRCs). The COVID‐19 Technology Accessibility Survey aimed to understand preferences of older adults regarding their research study visits and how they accessed the internet.ResultsAmong 12 ADRCs, 2070 responses were received (mean age: 72.8 years [standard deviation (SD) = 10.4], mean education: 16.6 years [SD = 2.6], race/ethnicity: 85% White/non‐Hispanic). Among respondents, those with some form of cognitive impairment were more likely to prefer remote research study visits (mild cognitive impairment [MCI] vs. normal [odds ratio (OR) = 1.40, P = 0.02] and dementia vs. normal [OR = 1.48, P < 0.01]). Respondents with cognitive impairment were also less likely to have interest in smartphone use during at‐home study visits (MCI vs. normal [OR = 0.71, P = 0.02] and dementia vs. normal [OR = 0.63, P < 0.001]). Results were similar regarding tablet use (MCI vs. normal [OR = 0.73, P = 0.04] and dementia vs. normal [OR = 0.72, P = 0.01]). Geographical location was analyzed in terms of the percentage of respondents in each region who preferred remote research study visits: West, 51%; Midwest, 34%; South, 41%; and Northeast, 57% (P < 0.0001).DiscussionResults from the study suggest that there is a growing interest in the remote research study visit format. Further studies will allow for greater understanding and development of this research format.
Dose‐response association between transportation noise exposure and type 2 diabetes: A systematic review and meta‐analysis of prospective cohort studies
Authors: Liu Chengzhi , Li Wenxin , Chen Xia , Liu Mingliang , Zuo Lei , Chen Li , Chen Haiyan , Xu Wenbin , Hao Guang 
Published: November 2022

AbstractAimsTo examine the longitudinal association between transportation noise exposure (road traffic, aircraft, and railway noise) and T2D in a meta‐analysis.Materials and MethodsWe systematically searched PubMed, Embase, Scopus, Cochrane, and Web of Science published up to February 2022. The GRADE approach was used to evaluate the study quality, and the pooled effect estimate was calculated by the fixed‐effects model or the random‐effects model.ResultsWe included 10 prospective studies with a total of 4,994,171 participants and 417,332 T2D cases in the meta‐analysis. According to the Navigation guide, 8 studies out of 10 were rated as having a probably high or high risk of bias. For road noise, the pooled relative risk (RR) per 10 dB higher Lden for developing T2D was 1.06 (95% CI:1.03, 1.09) with high heterogeneity (I2 = 90.1%, p < 0.001). Similar associations were also observed in aircraft and railway noise: the pooled RR were separately were: 1.01 (1.00, 1.01) and 1.02 (1.01, 1.03) separately. A ‘dose‐response’ analysis found a similar linear association between road noise exposure and the risk of T2D.ConclusionsAn overall 6% increase in the risk of T2D per 10 dB increase in road exposure was observed. Further studies are needed to confirm our findings, especially for aircraft and railway noise, and to identify the mechanisms involved.
Infant heart transplantation with extremely oversized donor heart: is the donor–recipient size matching too conservative?
Authors: Wen Shuyu , Zhou Ying , Qiao Weihua , Wang Yixuan , Zhang Jing , Dong Nianguo 
Published: November 2022

AbstractHeart transplantation (HTx) remains the gold standard treatment for end‐stage heart failure in children but is restricted due to the limitation of donors. The donor–recipient weight ratio (DRWR) of 0.8–2.5 was the main selection criterion, and reports were particularly scarce in cases of DRWR > 3.0. We present an infant HTx case with DRWR of 6.5. The recipient was a 66‐day‐old female infant, weighing 3 kg, diagnosed with complex congenital heart disease and refractory severe heart failure, whereas the donor was a 4‐year‐old girl weighing 19.5 kg. The phased delayed sternal closure was performed and accomplished on the 23rd day after operation without wound infection. After treating complications with extracorporeal membrane oxygenation, peritoneal dialysis, and mechanical ventilation, the patient was successfully discharged. After 1 year of follow‐up, the patient was still in optimal condition. Extending DRWR range may help enlarge the donor pool and shorten recipients' waiting time.
Effects of haemodynamically atrio‐ventricular optimized His bundle pacing on heart failure symptoms and exercise capacity: the His Optimized Pacing Evaluated for Heart Failure (HOPE‐HF) randomized, double‐blind, cross‐over trial
Authors: Whinnett Zachary I. , Shun‐Shin Matthew J. , Tanner Mark , Foley Paul , Chandrasekaran Badri , Moore Philip , Adhya Shaumik , Qureshi Norman , Muthumala Amal , Lane Rebecca , Rinaldi Aldo , Agarwal Sharad , Leyva Francisco , Behar Jonathan , Bassi Sukh , Ng Andre , Scott Paul , Prasad Rachana , Swinburn Jon , Tomson Joseph , Sethi Amarjit , Shah Jaymin , Lim Phang Boon , Kyriacou Andreas , Thomas Dewi , Chuen Jenny , Kamdar Ravi , Kanagaratnam Prapa , Mariveles Myril , Burden Leah , March Katherine , Howard James P. , Arnold Ahran , Vijayaraman Pugazhendhi , Stegemann Berthold , Johnson Nicholas , Falaschetti Emanuela , Francis Darrel P. , Cleland John G.F. , Keene Daniel 
Published: November 2022

AbstractAimsExcessive prolongation of PR interval impairs coupling of atrio‐ventricular (AV) contraction, which reduces left ventricular pre‐load and stroke volume, and worsens symptoms. His bundle pacing allows AV delay shortening while maintaining normal ventricular activation. HOPE‐HF evaluated whether AV optimized His pacing is preferable to no‐pacing, in a double‐blind cross‐over fashion, in patients with heart failure, left ventricular ejection fraction (LVEF) ≤40%, PR interval ≥200 ms and either QRS ≤140 ms or right bundle branch block.Methods and resultsPatients had atrial and His bundle leads implanted (and an implantable cardioverter‐defibrillator lead if clinically indicated) and were randomized to 6 months of pacing and 6 months of no‐pacing utilizing a cross‐over design. The primary outcome was peak oxygen uptake during symptom‐limited exercise. Quality of life, LVEF and patients' holistic symptomatic preference between arms were secondary outcomes. Overall, 167 patients were randomized: 90% men, 69 ± 10 years, QRS duration 124 ± 26 ms, PR interval 249 ± 59 ms, LVEF 33 ± 9%. Neither peak oxygen uptake (+0.25 ml/kg/min, 95% confidence interval [CI] −0.23 to +0.73, p = 0.3) nor LVEF (+0.5%, 95% CI −0.7 to 1.6, p = 0.4) changed with pacing but Minnesota Living with Heart Failure quality of life improved significantly (−3.7, 95% CI −7.1 to −0.3, p = 0.03). Seventy‐six percent of patients preferred His bundle pacing‐on and 24% pacing‐off (p < 0.0001).ConclusionHis bundle pacing did not increase peak oxygen uptake but, under double‐blind conditions, significantly improved quality of life and was symptomatically preferred by the clear majority of patients. Ventricular pacing delivered via the His bundle did not adversely impact ventricular function during the 6 months.
Incidence and clinical correlates of de‐novo aortic regurgitation with a fully magnetically levitated left ventricular assist device: a MOMENTUM 3 trial portfolio analysis
Authors: Uriel Nir , Milano Carmelo , Agarwal Richa , Lee Sangjin , Cleveland Joseph , Goldstein Daniel , Wang AiJia , Crandall Daniel , Mehra Mandeep R. 
Published: November 2022

AimsWe assessed the incidence, predictors and clinical correlates of de‐novo aortic regurgitation (AR), which physiologically reduces left ventricular assist device (LVAD) effectiveness due to recirculation syndrome, in the MOMENTUM 3 trial portfolio of the fully magnetically levitated HeartMate 3 (HM3) pump using the randomized pivotal trial (PT) and post‐trial continued access protocol (CAP).Methods and resultsDe‐novo aortic regurgitation incidence at 2 years was analysed in the randomized PT and validated in the first 1000 implanted patients of the CAP. Patients with concomitant/prior aortic valve surgery or without baseline or post‐implant echocardiograms were excluded from this analysis. AR severity was assessed qualitatively by site‐adjudicated echocardiograms (significant AR was defined as moderate or severe grade on echocardiogram). Of 1028 patients enrolled in the PT, 918 were eligible for inclusion in this analysis (HM3, n = 465; HMII, n = 453). At 2 years of LVAD support, freedom from significant AR was greater in the HM3 (92%) than HMII (82%) (hazard ratio 0.45, 95% confidence interval 0.27–0.75, p < 0.01). Of 907 HM3 patients analysed from the first 1000 implanted CAP patients, the rate of freedom from significant AR was 90%, consistent with the PT (p = 0.3). In the combined HM3 group (n = 1372), multivariable Cox modelling identified increasing age and female sex as significant predictors. Survival free of urgent transplant or AR corrective procedure was similar between HM3 patients with and without significant de‐novo AR.ConclusionsThe development of moderate or severe grade de‐novo AR is reduced with the fully magnetically levitated HM3 LVAD compared to the axial‐flow HMII pump. The occurrence of significant de‐novo AR with the HM3 pump is not associated with a worse outcome at 2 years of follow‐up.
Solvent‐Free Synthesis of Quaternary Oxazolidine‐2‐thione β3‐Amino Ester Analogs
Authors: Soddu Francesco , Devoto Federico , Marras Valentina , Caboni Pierluigi , Secci Francesco , Aitken David J. , Frongia Angelo 
Published: November 2022

AbstractA solvent‐free organocatalyzed intermolecular cyclization reaction starting from β‐substituted γ‐hydroxy‐α,β‐unsaturated esters and aryl isothiocyanates proceeds via an aza‐Michael addition to provide previously unknown quaternary oxazolidine‐2‐thione β3‐amino ester analogs. A panel of diversely‐substituted esters was investigated, including β,γ‐disubstituted examples which provided the target molecules with very high cis diastereoselectivity.
Low‐cost, high‐throughput and rapid‐prototyped 3D‐integrated dielectrophoretic channels for continuous cell enrichment and separation
Authors: Faraghat Shabnam A. , Fatoyinbo Henry O. , Hoettges Kai F. , Hughes Michael Pycraft 
Published: November 2022

AbstractMicrofluidic devices for dielectrophoretic cell separation are typically designed and constructed using microfabrication methods in a clean room, requiring time and expense. In this paper, we describe a novel alternative approach to microfluidic device manufacture, using chips cut from conductor–insulator laminates using a cutter plotter. This allows the manufacture of microchannel devices with micron‐scale electrodes along every wall. Fabrication uses a conventional desktop cutter plotter, and requires no chemicals, masks or clean‐room access; functional fluidic devices can be designed and constructed within a couple of hours at negligible cost. As an example, we demonstrate the construction of a continuous dielectrophoretic cell separator capable of enriching yeast cells to 80% purity at 10 000 cells/s.
Devices: A location for feminist analytics and praxis
Authors: Ballestero Andrea , Oyarzun Yesmar 
Published: November 2022

AbstractThis article offers the device as a methodological tool and concrete space for feminist praxis that can challenge the order of a world that is patriarchal, racist, and organized around capital extraction. Material or immaterial in form, a device is a tool through which different actors ground, produce, and concretize technological, legal, scientific, and political work. Many objects can become devices when pragmatically activated toward a particular effect; the challenge is to grasp them as such in the field and assess them for their political power and potential to bring forth possible worlds. Through examples from anthropology and adjacent literatures, we show how people accomplish three kinds of political work through their devices. Devices are sometimes used to solidify a domain of social life, such as the economy, the population, or race. Devices can constellate and produce a patterned effect, such as anti‐Blackness. Moreover, devices can be used to clear space for new and maybe unexpected possibilities. We end by articulating how the device, by way of its artificiality, offers potential pathways for furthering ethnographic and analytic practices and performing feminist political work.
Comparative study on comprehensive quality of Xinhui chenpi by two main plant propagation techniques
Authors: Tan E‐yu , Li Fang , Lin Xinheng , Ma Shaofeng , Zhang Guanghua , Zhou Hua , Ouyang Yue , Tang Ziyu , Cheng Qiqing 
Published: November 2022

AbstractXinhui chenpi (XHCP), the sun‐dried peel of the mandarin orange, Citrus reticulata “Chachi,” is the most famous crude drug, as well as a traditional seasoning in Chinese cooking. The main cultivation methods of XHCP are cutting and grafting, but it is generally considered that the quality of XHCP after cutting is superior to that obtained from plants propagated by graftings, which had a negative impact on the marketing of the finished product. In our study, a total of 25 samples of XHCP obtained from plants cultivated by either traditional methods (i.e., from cuttings) or by grafting were collected to compare the contents of four types of metabolites (essential oils, flavonoids, synephrine, and total polysaccharides) as well as antioxidant activity. The results revealed that the quality of XHCP did not decline after cutting, and marked individual differences between XHCP samples, even when prepared from plants grown in the same way. In general, grafting had no significant effect on the most essential oils components, total polysaccharides, synephrine, total flavonoids, total polymethoxylated flavones, hesperidin, nobiletin, tangeretin content, and antioxidant activity. Nevertheless, five volatile compounds can be used as potential chemical markers (p < 0.05) to distinguish between cutting XHCP and grafted XHCP, while four volatile compounds showed high content in grafted XHCP. Our study is expected to provide a theoretical basis for XHCP breeding and cultivation, and thereby further standardize the market of XHCP.