bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuromonitoring depth of anesthesia and its association with postoperative delirium
Authors: Pérez-Otal Berta , Aragón-Benedí Cristian , Pascual-Bellosta Ana , Ortega-Lucea Sonia , Martínez-Ubieto Javier , Ramírez-Rodríguez J. M. ,   Research Group in Anaesthesia, Resuscitation, and Perioperative Medicine of Institute for Health Research Aragón (ISS Aragón), Pérez-Otal Berta , Aragón-Benedí Cristian , Pascual-Bellosta Ana , Ortega-Lucea Sonia , Martínez-Ubieto Javier , Quesada-Gimeno Natividad , Muñoz-Rodríguez Luis Alfonso , Jiménez-Bernadó Teresa , Pérez-Navarro Guillermo , Lucas-Luesma Alejandro , Carbó-Espinosa Fernando , Hormigón-Ausejo Mariana , Ojeda-Cabrera Jorge Luis 
Published: July 2022

AbstractDelirium after surgery or Postoperative delirium (POD) is an underdiagnosed entity, despite its severity and high incidence. Patients with delirium require a longer hospital stay and present more postoperative complications, which also increases hospital costs. Given its importance and the lack of specific treatment, multifactorial preventive strategies are evidenced based. Our hypothesis is that using general anaesthesia and avoiding the maximum time in excessively deep anaesthetic planes through BIS neuromonitoring device will reduce the incidence of postoperative delirium in patients over the age of 65 and their hospitalization stay. Patients were randomly assigned to two groups: The visible BIS group and the hidden BIS neuromonitoring group. In the visible BIS group, the depth of anaesthesia was sustained between 40 and 60, while in the other group the depth of anaesthesia was guided by hemodynamic parameters and the Minimum Alveolar Concentration value. Patients were assessed three times a day by research staff fully trained during the 72 h after the surgery to determine the presence of POD, and there was follow-up at 30 days. Patients who developed delirium (n = 69) was significantly lower in the visible BIS group (n = 27; 39.1%) than in the hidden BIS group (n = 42, 60.9%; p = 0.043). There were no differences between the subtypes of delirium in the two groups. Patients in the hidden BIS group were kept for 26.6 ± 14.0 min in BIS values < 40 versus 11.6 ± 10.9 min (p < 0.001) for the patients in the visible BIS group. The hospital stay was lower in the visible BIS group 6.56 ± 6.14 days versus the 9.30 ± 7.11 days (p < 0.001) for the hidden BIS group, as well as mortality; hidden BIS 5.80% versus visible BIS 0% (p = 0.01). A BIS-guided depth of anaesthesia is associated with a lower incidence of delirium. Patients with intraoperative neuromonitoring stayed for a shorter time in excessively deep anaesthetic planes and presented a reduction in hospital stay and mortality.
Data-driven model discovery of ideal four-wave mixing in nonlinear fibre optics
Authors: Ermolaev Andrei V. , Sheveleva Anastasiia , Genty Goëry , Finot Christophe , Dudley John M. 
Published: July 2022

AbstractWe show using numerical simulations that data driven discovery using sparse regression can be used to extract the governing differential equation model of ideal four-wave mixing in a nonlinear Schrödinger equation optical fibre system. Specifically, we consider the evolution of a strong single frequency pump interacting with two frequency detuned sidebands where the dynamics are governed by a reduced Hamiltonian system describing pump-sideband coupling. Based only on generated dynamical data from this system, sparse regression successfully recovers the underlying physical model, fully capturing the dynamical landscape on both sides of the system separatrix. We also discuss how analysing an ensemble over different initial conditions allows us to reliably identify the governing model in the presence of noise. These results extend the use of data driven discovery to ideal four-wave mixing in nonlinear Schrödinger equation systems.
lncRNA-disease association prediction based on matrix decomposition of elastic network and collaborative filtering
Authors: Wang Bo , Liu RunJie , Zheng XiaoDong , Du XiaoXin , Wang ZhengFei 
Published: July 2022

AbstractIn recent years, with the continuous development and innovation of high-throughput biotechnology, more and more evidence show that lncRNA plays an essential role in biological life activities and is related to the occurrence of various diseases. However, due to the high cost and time-consuming of traditional biological experiments, the number of associations between lncRNAs and diseases that rely on experiments to verify is minimal. Computer-aided study of lncRNA-disease association is an important method to study the development of the lncRNA-disease association. Using the existing data to establish a prediction model and predict the unknown lncRNA-disease association can make the biological experiment targeted and improve its accuracy of the biological experiment. Therefore, we need to find an accurate and efficient method to predict the relationship between lncRNA and diseases and help biologists complete the diagnosis and treatment of diseases. Most of the current lncRNA-disease association predictions do not consider the model instability caused by the actual data. Also, predictive models may produce data that overfit is not considered. This paper proposes a lncRNA-disease association prediction model (ENCFLDA) that combines an elastic network with matrix decomposition and collaborative filtering. This method uses the existing lncRNA-miRNA association data and miRNA-disease association data to predict the association between unknown lncRNA and disease, updates the matrix by matrix decomposition combined with the elastic network, and then obtains the final prediction matrix by collaborative filtering. This method uses the existing lncRNA-miRNA association data and miRNA-disease association data to predict the association of unknown lncRNAs with diseases. First, since the known lncRNA-disease association matrix is very sparse, the cosine similarity and KNN are used to update the lncRNA-disease association matrix. The matrix is then updated by matrix decomposition combined with an elastic net algorithm, to increase the stability of the overall prediction model and eliminate data overfitting. The final prediction matrix is then obtained through collaborative filtering based on lncRNA.Through simulation experiments, the results show that the AUC value of ENCFLDA can reach 0.9148 under the framework of LOOCV, which is higher than the prediction result of the latest model.
Oxidative stress differentially impacts apical and basolateral secretion of angiogenic factors from human iPSC-derived retinal pigment epithelium cells
Authors: Chen Lisheng , Perera N. Dayanthi , Karoukis Athanasios J. , Feathers Kecia L. , Ali Robin R. , Thompson Debra A. , Fahim Abigail T. 
Published: July 2022

AbstractThe retinal pigment epithelium (RPE) is a polarized monolayer that secretes growth factors and cytokines towards the retina apically and the choroid basolaterally. Numerous RPE secreted proteins have been linked to the pathogenesis of age-related macular degeneration (AMD). The purpose of this study was to determine the differential apical and basolateral secretome of RPE cells, and the effects of oxidative stress on directional secretion of proteins linked to AMD and angiogenesis. Tandem mass tag spectrometry was used to profile proteins in human iPSC-RPE apical and basolateral conditioned media. Changes in secretion after oxidative stress induced by H2O2 or tert-butyl hydroperoxide (tBH) were investigated by ELISA and western analysis. Out of 926 differentially secreted proteins, 890 (96%) were more apical. Oxidative stress altered the secretion of multiple factors implicated in AMD and neovascularization and promoted a pro-angiogenic microenvironment by increasing the secretion of pro-angiogenic molecules (VEGF, PTN, and CRYAB) and decreasing the secretion of anti-angiogenic molecules (PEDF and CFH). Apical secretion was impacted more than basolateral for PEDF, CRYAB and CFH, while basolateral secretion was impacted more for VEGF, which may have implications for choroidal neovascularization. This study lays a foundation for investigations of dysfunctional RPE polarized protein secretion in AMD and other chorioretinal degenerative disorders.
Horizon scanning process to foresight emerging issues in Arabsphere's water vision
Authors: Batisha Ayman 
Published: July 2022

AbstractThe Arabsphere struggles with highly complicated water challenges due to climate change, desertification, coronavirus pandemic, and Russo-Ukrainian War. This paper explores how to build a robust water vision to pave the road to achieving sustainable development goals (SDGs) in the Arabsphere. A sustainable water future (SWF) necessitates an interdisciplinary and transdisciplinary research strategy. ‘Horizon scanning’ process (HSP) is one of the promising foresight methodologies. A generic process for “Horizon scanning” has been developed to cope with water crises and challenges. “DEEPEST” holistic framework has been designed to suit both the “Futurology” science and water, environment, and engineering disciplines. “DEEPEST” characterizes Demographics, Ecological, Environmental, Political, Economic, Social, and Technological features. The macro-future factors (MFF) applied in the foresight process (FP) have been presented. The results showed that Water conservation (WC), Circular Water (CW), and Emerging Water Technologies (EWTs) were the main outcomes of the ‘Horizon scanning’ process (HSP). The paper concluded that the preparing for a sustainable water future (SWF) must be right now and the opportunities range from the deepest water drop to the highest water drop on Earth. The essence of the conclusion is hydrosphere sustainability, particularly in Arabsphere, should be given extreme concentration, effort, and support.
The School-Based Speech-Language Pathologist and Students With Concussion: An Examination of Evolving Knowledge and Confidence
Authors: O'Brien Katy H. , Lundine Jennifer P. , Pei Yalian , Kemp Amy M. 
Published: July 2022

Purpose:This study examines school-based speech-language pathologists' (SLPs’) experience, knowledge, and confidence in supporting students as they return to the classroom following concussion, with a particular focus on knowledge of new management guidelines over the last decade.Method:Participants were 74 school-based SLPs who completed an electronic survey about their knowledge and experiences serving students with concussion. We examined participants' accuracy and confidence across knowledge questions using Kruskal–Wallis tests. We also conducted linear regression to explore the relationships between training, work experiences, knowledge, and confidence.Results:Nearly half of participants who are currently working with students with concussion reported having no clinical or training experiences related to concussion. Participants who had more concussion-related training or working experiences reported higher confidence. Participants were confident about general concussion knowledge but less confident about providing assessment and supporting students with concussion as they returned to school. Participants had the lowest confidence and accuracy for the most recent guidelines around rest and activity, as well as the differential impact of concussion on children as compared to adults.Conclusions:Many school-based SLPs have limited training around concussion management and are often not specifically consulted to work with students following concussion. Despite this, SLPs have good awareness of their knowledge about concussion, but show gaps in knowledge surrounding more recent evidence-based guidelines. Additional investigation is needed to determine better ways to move research into clinical practice and to increase the involvement of SLPs in school-based concussion teams.Supplemental Material:https://doi.org/10.23641/asha.20361969
S2k-Leitlinie Hüftdysplasie Teil Säugling
Authors: Seidl Tamara , Thielemann Falk , Gerhardt Anke , Gaulrapp Hartmut , Zierl Angelika , Buchholz Silke , Naumann Antje , Winter Bettina , Rodens Klaus 
Published: July 2022

ZusammenfassungHüftreifungsstörungen stellen in Mitteleuropa die häufigste muskuloskelettale Erkrankung im Neugeborenalter dar. Der Begriff Hüftreifungsstörung umfasst dabei sowohl dysplastische als auch
luxierte Gelenke. Bei einem dysplastischen Gelenk kommt es aufgrund von Scherkräften zu einer Wachstumsstörung im Bereich der Hüftpfanne. Bei einem Fortbestehen der Wachstumsstörung im Bereich
der Hüftpfanne verdrängt der Hüftkopf den knorpelig präformierten Anteil der Gelenkpfanne erst nach kranial und luxiert schlussendlich nach dorsal in die Fossa glutealis. Der Hüftkopf verliert
bei der Luxation zunehmend den Kontakt zur Pfanne. Wir sprechen dementsprechend heute von einer Developmental Dislocation of the Hip und nicht mehr von einer Congenital Dislocation of the Hip.
Die verschiedenen Stadien der Hüftreifungsstörung lassen sich anhand einer Ultraschalluntersuchung des Säuglingshüftgelenks nach Graf ab dem 1. Lebenstag exakt klassifizieren. Die
Hüftultraschalluntersuchung nach Graf ist daher seit 1996 in Deutschland fester Bestandstandteil der Kinderrichtlinie. Alle Neugeborenen müssen im Rahmen der 3. Vorsorgeuntersuchung U3
idealerweise im Alter von 4–5 (maximal 8) Wochen einer Hüftultraschalluntersuchung nach Graf unterzogen werden. Bei Neugeborenen mit anamnestischen oder klinischen Risikofaktoren muss darüber
hinaus bereits bei der 2. Vorsorgeuntersuchung U2 in der 1. Lebenswoche neben einer klinischen Untersuchung der Hüftgelenke auch eine Ultraschalluntersuchung erfolgen. Basierend auf dieser
Frühestdiagnostik sollte bei pathologischen Befunden möglichst innerhalb 1 Woche eine dem Befund entsprechende Therapie eingeleitet werden. Luxierte Gelenke werden reponiert. Nach
Wiederherstellen des Kontakts von Hüftkopf und Pfanne ist es zwingend erforderlich, dass der Kopf sicher in der Pfanne gehalten wird. Nach dieser Phase der Retention schließt sich bei luxierten
Gelenken die für dysplastische Gelenke als Therapie ausreichende Nachreifungsphase an. Um eine Hüftkopfnekrose als Frühkomplikation oder eine erneute Hüftreifungsstörung im weiteren Wachstum zu
vermeiden, wird der Hüftkopf sowohl während der Retentionsphase als auch während der Nachreifungsphase tief in die Pfanne eingestellt. Dies gelingt bei Sicherstellung einer Hüftflexion von
100–110° bei gleichzeitiger Hüftabduktion von 50° bis maximal 60°.
Isolated Posterior Instrumentation for Selected Cases of Thoracic and Lumbar Spinal Tuberculosis without Radical Debridement
Authors: Ye Shuming , Sun Jian , Jing Juehua 
Published: July 2022

Abstract
Background The purpose of this study was to evaluate the clinical outcomes of thoracic and lumbar spinal tuberculosis treated with isolated posterior instrumentation without radical
debridement.
Methods This study retrospectively analyzed 73 patients with thoracic and lumbar spinal tuberculosis who were treated using isolated posterior instrumentation without radical
debridement in our hospital between January 2012 to December 2019. The patient group was composed of 42 men and 31 women with a mean age of 67.3 ± 8.6 years. The tuberculosis spine
instability score (TSIS) was used to evaluate spine stability. All patients received chemotherapy for 18 months after surgery. The time of surgery, blood loss, visual analogue score (VAS),
kyphosis angle, Oswestry disability index (ODI), erythrocyte sedimentation rate (ESR), Frankel grading, SF-36 scores, and local recurrence and complications were analyzed to evaluate the
efficacy of isolated posterior instrumentation surgery in the treatment of thoracic and lumbar spinal tuberculosis.
Results All patients were followed up for 12 to 24 months (mean 14 ± 3.2 months). The mean surgical time was 1.2 ± 1.4 h (range, 1.2–1.6 h), and mean blood loss was 107 ± 18 mL. The
postoperative symptoms were obviously relieved. The VAS, kyphosis angle, DI, and ESR decreased, respectively, from 8.24 ± 1.32, 19.82 ± 3.42, 46.25 ± 3.62, and 49.64 ± 17.61 to 1.12 ± 0.21,
7.14 ± 0.81, 20.17 ± 5.11, and 0.35 ± 1.13 at final follow-up. In comparison to preoperative values, SF-36 scores were significantly improved at final follow-up and the differences were
statistically significant (p < 0.05). All patients achieved neurological recovery at the final follow-up. There were no recurrences or complications in any of the patients.
Conclusion Isolated posterior instrumentation without radical debridement is a suitable minor surgical trauma that offers a remarkable advantage of effective pain relief, improvement
in neurological function and performance status, and no local recurrence for selected patients with thoracic and lumbar spinal tuberculosis.
Applying the Hearing Aid Fitting Standard to Selection for Adults
Authors: Picou Erin M. , Roberts Richard A. , Angley Gina , Ricketts Todd A. 
Published: July 2022

AbstractThe recent hearing aid fitting standard for adults outlines the minimum practice for audiologists fitting adult patients with hearing loss. This article focuses on three items of the standard (5, 6, and 7), which focus on the selection of unilateral/bilateral hearing aids, hearing aid style, and coupling, in addition to feature selection. The standard emphasizes that decisions around these three aspects should be recommended for a patient in an individualized manner, based on their needs assessment. For these decisions, the needs assessment might include measures of speech-in-noise ability, social network size, patient preference, and a trial period. Additional elements could include assessments of manual dexterity, binaural interference, and attitude toward hearing aids. However, there are a multitude of ways to practice clinically and still meet the items outlined in the standard. As long as the selection decisions consider individualized patient factors and are capable of meeting validated prescriptive targets, a clinician would be meeting the adult hearing aid fitting minimum standard guidance. In addition, despite the large number of past studies supporting these standards, additional, high-quality research including randomized, controlled, clinical trials are still needed to further support appropriate minimum standard recommendations.
Verification and Validation: Just the Standards
Authors: Jorgensen Lindsey E. , Novak Michelle ,   and
Published: July 2022

AbstractThe Audiology Practice Standards Organization (APSO) has published its second audiology standard. This second standard is focused on adult hearing aid fittings. These standards put forward information about verification that should be completed on hearing aids before, during, and after a fitting. Validation following the verification of the hearing aids to ensure patient satisfaction with the devices is also included in the standards. The goal of this article is to provide clinicians with the guidelines related to hearing aid verification and validation while also providing information about how to put these standards into clinical practice.
Acute Myeloid Leukemia with Concurrent Inversion 16 and Trisomy 9: A Case Report
Authors: Aman Ambreen , Lingappa Kavitha B. , Sujatha Deepika G. , Rajasab Subhan Ali , Shantala Siddapa 
Published: July 2022

AbstractAcute myeloid leukemia (AML) are a diverse group of hematological malignancies, each with a distinct clinical, morphological, immunophenotypic, and molecular profile. The World Health Organization (WHO) classifies AML into various subtypes based on recurrent genetic abnormalities, each of which has clinico-pathological and prognostic significance. Inversion(16)(p13q22) or t(16;16)(p13q22) is a balanced structural chromosomal abnormality associated with complete remission and a favorable response to treatment. Trisomy 9 is a numerical chromosomal abnormality with an intermediate risk and is often seen in association with other cytogenetic abnormalities. We describe a case of a 36-year-old female patient who was diagnosed as AML-M4 on peripheral smear and bone marrow evaluation. Cytogenetic studies revealed concurrent presence of inv(16) and trisomy 9. To the best of our knowledge, this is the first case in published literature with simultaneous presence of inv(16)(p13q22) and trisomy 9 in de novo AML.
Impact of Pneumatic Transport System on Preanalytical Phase Affecting Clinical Biochemistry Results
Authors: Kumari Sweta , Kumar Santosh , Bharti Neha , Shekhar Ravi 
Published: July 2022

Abstract
Introduction PTS (pneumatic transport system) is extensively being used in modern hospitals for rapid transportation of blood samples and other specimens. However, it has a potential impact on blood components, which should be investigated and nullified accordingly. This study was part of a correction program aimed at reducing hemolysis. It was done by comparing paired samples transported manually and by PTS.
Materials and Methods This study was initiated to monitor the impact of PTS on hemolysis of clinical biochemistry blood samples. It was performed in two phases—before and after the corrective action taken. Phase I: done after PTS installation but before the corrective action was taken. Duplicate samples from 100 healthy individuals were collected, one set transported by PTS and the other by human carriers. Both sets were assessed for 25 biochemistry analytes, hemolysis index (HI), and acceleration profiles using a data logger. Corrective measures were then taken, followed by phase II of the study. In phase II, the sample size and study design remained the same as phase I. All the test results of PTS and hand-carried samples were statistically analyzed for any significant difference.
Result In phase I, all the hemolysis-manifesting parameters, LDH (lactate dehydrogenase), potassium, AST (aspartate transaminase), and phosphorus, were raised in PTS samples as compared with the manual samples. Their differences were significant as the p-values were 0.001, 0.000, 0.025, and 0.047, respectively. The differences for LDH and potassium were clinically significant as well. HI (9%) and peak acceleration (15.7 g) were high in PTS samples.In phase II, no statistically significant difference between paired samples was found for all biochemistry parameters except for a few which were clinically nonsignificant. For PTS samples, HI was 2.5% and the peak acceleration was 11.2 g, whereas for manual samples, HI was 2%.
Conclusion Evidence of hemolysis was found in PTS samples as compared with handheld samples, which was resolved after several corrective actions were taken. Thereafter, PTS became reliable for sample delivery in a routine biochemistry laboratory. Hence, each hospital should scrutinize their PTS for its effects on sample integrity to get rid of PTS-induced preanalytical errors.
Posttreatment Persistence of Monoclonal Protein on Immunofixation Electrophoresis but Absence on Serum Protein Electrophoresis in a Case of Solitary Bone Plasmacytoma
Authors: Kumar Visesh , Rani Priti , Rai Neha , Kumar Subhash , Mahto Mala 
Published: July 2022

AbstractLaboratory investigations for any suspected case of solitary plasmacytoma of bone include routine biochemical and hematological investigations along with β2-microglobulin, electrophoresis of serum protein and/or 24-hour urine protein, serum protein immunofixation (IFE), and nephelometric quantification of total immunoglobulin isotype and serum free light chain levels. Bone marrow aspirate and trephine biopsy are mandatory to confirm the absence of clonal plasma cells (for solitary plasmacytoma) or the presence of less than 10% clonal cells (solitary plasmacytoma with minimal bone marrow involvement). Imaging studies such as X-ray, computed tomography (CT), magnetic resonance imaging, and positron emission tomography/CT should be used to complement laboratory tests in diagnosis, staging, and defining the local extent of the plasmacytoma. However, guidelines regarding choice of technique for the detection of M band when monitoring a follow-up case of operated plasmacytoma are still not clear. Through this case study, we try to highlight the role of IFE in a follow-up case of operated solitary plasmacytoma of the bone.