bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of clinical characteristics, eating behaviors, and clinical symptoms following fat intake in functional dyspepsia with functional dyspepsia with pancreatic enzyme abnormalities between Singapore and Japan
Authors: Futagami Seiji , Kessoku Takaomi , Kasai Yuki , Higurashi Takuma , Nakajima Atsushi , Agawa Shuhei , Yamawaki Hiroshi , Habiro Mayu , Ueki Nobue , Sanada Iori , Yamamoto Mariko , Watanabe Yoshiyuki , Yamato Hiroshi , Yamamoto Takatsugu , Takasaki Yusuke , Ito Koichi , Hojo Mariko , Isayama Hiroyuki , Siah Kewin Tien Ho , Gwee Kok‐Ann 
Published: May 2022

AbstractBackground and AimTo clarify whether there were any significant differences in clinical symptoms and eating patterns between functional dyspepsia (FD) patients and FD with pancreatic enzyme abnormalities (FD‐P) patients as refractory FD, we compared these factors in multicenter studies in Singapore and Japan.MethodsOne hundred ninety‐eight consecutive patients presenting with FD (n = 88), FD‐P patients (n = 81) based on Rome III classification and controlled group (n = 39) recruited from six institutions in Singapore and Japan. Clinical characteristics, clinical symptoms for dietary fat intake, and eating behaviors were estimated using questionnaires. Anxiety and health‐related quality of life were determined by STAI‐state/‐trait and SF‐8, respectively.ResultsThere were no significant differences in age, sex, BMI, smoking, alcohol intake, past medical history, and history of allergy in FD and FD‐P patients between Singapore and Japan. There were no significant differences in FD subtypes, gastrointestinal symptom rating scale score, severity of FD symptoms, and eating pattern in Singapore and Japan. Moreover, there were significant differences in certain eating behaviors between FD and FD‐P patients in Singapore and Japan. Interestingly, epigastric pain and early satiety following fat meals in FD‐P patients were significantly (P = 0.003 and P = 0.008, respectively) higher compared with those in FD patients in Japan. Physical component score in FD‐P patients was significantly (P = 0.019) disturbed compared with those in FD patients in Japan.ConclusionsEpigastric pain and early satiety following fat meals in FD‐P patients may be useful tools to differentiate FD‐P patients from FD patients in Japan.
Dynamic lighting schedules to facilitate circadian adaptation to shifted timing of sleep and wake
Authors: Rahman Shadab A. , St. Hilaire Melissa A. , Grant Leilah K. , Barger Laura K. , Brainard George C. , Czeisler Charles A. , Klerman Elizabeth B. , Lockley Steven W. 
Published: May 2022

AbstractCircadian adaptation to shifted sleep/wake schedules may be facilitated by optimizing the timing, intensity and spectral characteristics of light exposure, which is the principal time cue for mammalian circadian pacemaker, and possibly by strategically timing nonphotic time cues such as exercise. Therefore, circadian phase resetting by light and exercise was assessed in 44 healthy participants (22 females, mean age [±SD] 36.2 ± 9.2 years), who completed 8‐day inpatient experiments simulating night shiftwork, which included either an 8 h advance or 8 h delay in sleep/wake schedules. In the advance protocol (n = 18), schedules were shifted either gradually (1.6 h/day across 5 days) or abruptly (slam shift, 8 h in 1 day and maintained across 5 days). Both advance protocols included a dynamic lighting schedule (DLS) with 6.5 h exposure of blue‐enriched white light (704 melanopic equivalent daylight illuminance [melEDI] lux) during the day and dimmer blue‐depleted light (26 melEDI lux) for 2 h immediately before sleep on the shifted schedule. In the delay protocol (n = 26), schedules were only abruptly delayed but included four different lighting conditions: (1) 8 h continuous room‐light control; (2) 8 h continuous blue‐enriched light; (3) intermittent (7 × 15 min pulses/8 h) blue‐enriched light; (4) 8 h continuous blue‐enriched light plus moderate intensity exercise. In the room‐light control, participants received dimmer white light for 30 min before bedtime, whereas in the other three delay protocols participants received dimmer blue‐depleted light for 30 min before bedtime. Both the slam and gradual advance protocols induced similar shifts in circadian phase (3.28 h ± 0.37 vs. 2.88 h ± 0.31, respectively, p = .43) estimated by the change in the timing of timing of dim light melatonin onset. In the delay protocol, the continuous 8 h blue‐enriched exposure induced significantly larger shifts than the room light control (−6.59 h ± 0.43 vs. −4.74 h ± 0.62, respectively, p = .02). The intermittent exposure induced ~60% of the shift (−3.90 h ± 0.62) compared with 8 h blue‐enriched continuous light with only 25% of the exposure duration. The addition of exercise to the 8 h continuous blue‐enriched light did not result in significantly larger phase shifts (−6.59 h ± 0.43 vs. −6.41 h ± 0.69, p = .80). Collectively, our results demonstrate that, when attempting to adapt to an 8 h overnight work shift, delay shifts are more successful, particularly when accompanied by a DLS with high‐melanopic irradiance light stimulus during wake.
Knowledge gaps in the management of refractory reflux‐like symptoms: Healthcare provider survey
Authors: Armstrong David , Hungin Amrit Pali , Kahrilas Peter J. , Sifrim Daniel , Sinclair Paul , Vaezi Michael F. , Sharma Prateek 
Published: May 2022

AbstractBackgroundRefractory reflux‐like symptoms have a substantial impact on patients and healthcare providers. The aim of the survey was to qualitatively assess the needs and attitudes of practicing clinicians around the management of refractory reflux symptoms and refractory gastroesophageal reflux disease (rGERD).MethodsAn International Working Group for the Classification of Oesophagitis (IWGCO) steering committee invited clinicians to complete an online survey including 17 questions.Key resultsOf the 113 clinicians who completed the survey, 70% were GIs, 20% were primary care physicians, and 10% were other specialties. Functional heartburn was considered the most common reason for an incomplete response to proton pump inhibitor (PPI) therapy (82%), followed by stress/anxiety (69%). More GIs identified esophageal hypersensitivity as a cause, while more non‐GIs identified esophageal dysmotility and non‐reflux‐related esophageal conditions. As the first step, most clinicians would order investigations (70–88%). Overall, 72% would add supplemental therapy for patients with partial response, but only 58% for those with non‐response. Antacid/alginate was the most common choice overall, while non‐GIs were more likely to add a prokinetic than were GIs (47.8 vs. 24.1%). Approximately 40% of clinicians would switch PPIs in patients with partial response, but only 29% would do so in non‐responders. Preferences for long‐term therapy were highly variable. The most common initial investigation was upper endoscopy. Choice of esophageal manometry and pH monitoring was more variable, with no clear preference for whether pH monitoring should be conducted on, or off, PPI therapy.Conclusions and InferencesThe survey identified a number of challenges for clinicians, especially non‐GI physicians, treating patients with refractory reflux‐like symptoms or rGERD on a daily basis.
The role of the primary motor cortex in motor imagery: A theta burst stimulation study
Authors: Barhoun Pamela , Fuelscher Ian , Do Michael , He Jason L. , Cerins Andris , Bekkali Soukayna , Youssef George J. , Corp Daniel , Major Brendan P. , Meaney Dwayne , Enticott Peter G. , Hyde Christian 
Published: May 2022

AbstractWhile mentally simulated actions activate similar neural structures to overt movement, the role of the primary motor cortex (PMC) in motor imagery remains disputed. The aim of the study was to use continuous theta burst stimulation (cTBS) to modulate corticospinal activity to investigate the putative role of the PMC in implicit motor imagery in young adults with typical and atypical motor ability. A randomized, double blind, sham‐controlled, crossover, offline cTBS protocol was applied to 35 young adults. During three separate sessions, adults with typical and low motor ability (developmental coordination disorder [DCD]), received active cTBS to the PMC and supplementary motor area (SMA), and sham stimulation to either the PMC or SMA. Following stimulation, participants completed measures of motor imagery (i.e., hand rotation task) and visual imagery (i.e., letter number rotation task). Although active cTBS significantly reduced corticospinal excitability in adults with typical motor ability, neither task performance was altered following active cTBS to the PMC or SMA, compared to performance after sham cTBS. These results did not differ across motor status (i.e., typical motor ability and DCD). These findings are not consistent with our hypothesis that the PMC (and SMA) is directly involved in motor imagery. Instead, previous motor cortical activation observed during motor imagery may be an epiphenomenon of other neurophysiological processes and/or activity within brain regions involved in motor imagery. This study highlights the need to consider multi‐session theta burst stimulation application and its neural effects when probing the putative role of motor cortices in motor imagery.
Long‐run effects of trade liberalisation on local labour markets: Evidence from South Africa
Authors: Bastos Paulo , Santos Nicolas 
Published: May 2022

AbstractThis paper uses municipal‐level data from South Africa for the period 1996–2011 to estimate the medium to long‐run effects of trade liberalisation on local labour markets. It finds that local labour markets that were more exposed to tariff cuts tended to experience slower growth in employment and income per capita than less exposed regions. The longer‐term effects of trade liberalisation on regional earnings are stronger than the medium‐term effects and tend to be more pronounced among municipalities that included the former homelands.
Estimation of Tissue Movement in Needle Insertion Tasks Using an Active Needle
Authors: Padasdao Blayton , Batsaikhan Zolboo , Brown Dailen , Moore Jason , Konh Bardia 
Published: May 2022

Abstract
Needle insertion has been used as a minimally invasive technique in many diagnostic or therapeutic procedures such as prostate biopsy or brachytherapy. While the success of these procedures relies on accurate positioning of the needle tip at target positions, the intraoperative movement of the tissue (and consequently the target) has caused physicians some difficulties in acquiring the target. This paper presents a method to estimate tissue movement during a needle insertion task within tissue. The movement of the tissue is valuable information for guidance, navigation, and control of the needle inside tissue towards the target. A needle insertion task was performed using an active needle bending. Ultrasound images were captured at four needle insertion stages of initial needle insertion, bending, unbending, and needle retraction. Ultrasound images were then analyzed to estimate the tissue movement at each stage. The study showed that needle retraction, insertion, bending, and unbending stages correspond to largest to lowest tissue movement, respectively.
A Portable Robot to Perform Prostate Brachytherapy with Active Needle Steering and Robot-Assisted Ultrasound Tracking
Authors: Rabiei Mahsa , Konh Bardia 
Published: May 2022

Abstract
Brachytherapy is an internal radiation therapy method for prostate cancer that involves placement of radioactive seeds close to the cancerous cells. Robotic needle insertion systems have been proposed in the past to help physicians to improve outcomes of brachytherapy. This work presents design and development of a portable robotic brachytherapy system to operate a tendon-driven active needle based on physician’s input. The system enables manual positioning of the needle to choose appropriate puncture positions as well as robotic manipulation mechanisms for needle insertion and bending. The system also allows for automatic movement of an ultrasound probe to visualize the needle tip in a needle insertion task in real time.
Computer Vision Enabled Smart Tray for Central Venous Catheterization Training
Authors: Brown Dailen , Wu Hang-Ling , Satpathy Yohaan , Gonzalez-Vargas Jessica M. , Tzamaras Haroula , Miller Scarlett , Moore Jason 
Published: May 2022

Abstract
A Computer Vision enabled Smart Tray (CVST) was designed for use in medical training for Central Venous Catheterization (CVC). The effects of background color on the ability of the computer vision algorithm to distinguish between tools and the tray was investigated. In addition, the computer vision algorithm was evaluated for accuracy in tool detection. Results indicate that a white monochromatic background is the most useful for segregating background from medical tools, and the algorithm was successfully able to detect 5 different CVC tools both individually and as a group in various arrangements, even when tools overlapped or touched. When the system was in error, it was nearly always due to one tool which has a color similar to that of the background. The CVST shows promise as a CVC training tool and demonstrates that computer vision can be used to accurately detect medical tools.
Design and Development of System Components for Therapeutic Ultrasound Devices: Enhancing Focused Ultrasound Treatments Using Cones with Clinical and Ergonomic Considerations
Authors: Thombre Rasika , Mess Griffin , Curry Eli , Mejia Richard , Liang Ruixing , Aghabaglou Fariba , Kerensky Max , Abramson Haley , VanSickle Roslyn , Tyler Betty , Theodore Nicholas , Manbachi Amir 
Published: May 2022

Abstract
Focused ultrasound (FUS) is an emerging technique with the potential to revolutionize traditional treatment methods in the fields of oncology and neurosurgery. Recently, FUS treatments have shown potential for altering neural activity in the spinal cord, with the intent to alleviate pain. Preliminary animal studies using FUS have demonstrated the need for transducer accessories that can simplify the implementation of the transducer in the clinic. The coupling cone that was supplied with the transducer was designed for larger target tissues. Thus, surgeons have expressed a desire to adapt the cone design to be easier to use for smaller targets, such as the spinal cord. Here, we developed 3D printed cones, with smaller aperture sizes, for FUS transducers to assist surgeons in localizing the focal point of the transducers in a faster, and more intuitive manner. The cones were designed to not alter the original focal region of the transducers. This was experimentally confirmed by measuring the size of the focal region for the transducer with the new cones and comparing this data to measurements provided by the manufacturer. The new coupling cones will make the FUS transducers more ergonomic for use in stimulating the spinal cord in an animal model.
Design Guidelines for Moving a Human Body on a Bed Using Traveling Waves
Authors: Mansouri Mahshid , Krishnan Girish , Hsiao-Wecksler Elizabeth T. 
Published: May 2022

Abstract
Inspired by natural waves such as water waves that can carry objects, this study presents design guidelines for moving a human body using traveling waves created on the surface of a bed. Particularly, through kinematic analysis and simulation of a traveling wave, the study explores various parameters, such as the wave’s frequency, wavelength, amplitude, number of wave-generating actuators and their movement pattern under the body. The study also investigates how these parameters affect human transportation speed and movement smoothness. The study results suggest that transportation speed is linearly proportional to the wave frequency. Additionally, to increase movement smoothness, the wave amplitude should be reduced while the number of actuators should be maximized. However, there is a tradeoff between the number of actuators that can be used and the complexity of the system’s design and control.
Neonatal hydrocolpos presenting as a rapidly progressive abdominal mass with inferior caval vein syndrome
Authors: Nowacki Relana M E , Derikx Joep P M , Roeleveld-Versteegh Angelique B C , Leroy Piet L J M 
Published: May 2022

A 7-week-old infant was presented at the emergency department with an abdominal mass, unilateral swelling of the groin and suspicion of an inferior caval vein syndrome with bluish discolouration and oedema of the lower extremities. Abdominal imaging showed two large cysts and profound bilateral hydronephrosis. Following laparotomy, an extreme hydrocolpos and an overdistended urinary bladder were found. These findings turned out to be secondary to a transverse vaginal septum. She was treated surgically and was hospitalised for 2 weeks. Long-term follow-up showed normalisation of previously present hypercalciuria and hydronephrosis.A hydro(metro)colpos should be considered in the differential diagnosis of a female infant presenting with an abdominal mass, to apply the appropriate investigations and therapy.
Demographic, exposure and clinical characteristics in a multinational registry of engineered stone workers with silicosis
Authors: Hua Jeremy Tang , Zell-Baran Lauren , Go Leonard H T , Kramer Mordechai R , Van Bree Johanna B , Chambers Daniel , Deller David , Newbigin Katrina , Matula Michael , Fireman Elizabeth , Dahbash Mor , Martinez-Gonzalez Cristina , León-Jimenez Antonio , Sack Coralynn , Ferrer Jaume , Villar Ana , Almberg Kirsten S , Cohen Robert A , Rose Cecile S 
Published: May 2022

ObjectivesTo investigate differences in workplace exposure, demographic and clinical findings in engineered stone (ES) workers from a multinational consortium using the Engineered Stone Silicosis Investigators (ESSI) Global Silicosis Registry.MethodsWith ethics board approval in Israel, Spain, Australia and the USA, ES workers ages 18+ with a physician diagnosis of work-related silicosis were enrolled. Demographic, occupational, radiologic, pulmonary function and silica-related comorbidity data were compared cross-sectionally among countries using analysis of variance, Fisher’s exact tests and logistic regression.ResultsAmong 169 ES workers with silicosis, most were men, with mean age 51.7 (±11.4) years. Mean work tenure in stone fabrication or masonry was 19.9 (±9.8) years. Different methods of case ascertainment explained some inter-country differences, for example, workers in Queensland, Australia with a state-based surveillance program were likely to be identified earlier and with shorter work tenure. Overall, 32.5% of workers had progressive massive fibrosis, the most severe form of dust-related pneumoconiosis, of whom 18.5% reported ≤10 years of work tenure. Lung function impairment including restriction, reduced diffusion capacity and hypoxaemia was common, as was autoimmunity.ConclusionsFindings from a multinational registry represent a unique effort to compare demographic, exposure and clinical information from ES workers with silicosis, and suggest a substantial emerging population of workers worldwide with severe and irreversible silica-associated diseases. This younger worker population is at high risk for disease progression, multiple comorbidities and severe disability. The ESSI registry provides an ongoing framework for investigating epidemiological trends and developing prospective studies for prevention and treatment of these workers.
Occupational trichloroethylene exposure and antinuclear antibodies: a cross-sectional study in China
Authors: Purdue Mark , Zhang Luoping , Vermeulen Roel , Smith Martyn T , Hu Wei , Rhee Jongeun , Wen Cuiju , Huang Yongshun , Tang Xiaojiang , Berndt Sonja I , Frazer-Abel Ashley A , Deane Kevin D , Rothman Nathaniel , Lan Qing 
Published: May 2022

ObjectivesThere has been concern over the possible risk of autoimmune diseases from exposure to trichloroethylene (TCE), an industrial solvent and common pollutant near hazardous waste sites. Studies of TCE-exposed lupus-prone mouse strains have reported increases in serum antinuclear antibodies (ANAs), a marker of autoimmunity, and autoimmune pathologic changes, while epidemiologic studies have provided limited support for an association between TCE exposure and scleroderma. To investigate exposure-related biologic evidence of autoimmunity in humans, we measured ANA levels in sera from a cross-sectional study of TCE-exposed (n=80) and TCE-unexposed (n=96) workers in Guangdong, China.MethodsFull-shift personal air exposure measurements for TCE were taken prior to blood collection. Serum ANAs were detected by immunofluorescence on HEp-2 cells. We calculated ORs and 95% CI relating levels of TCE exposure (categorised using tertiles as cut-points) and ANA positivity (1+ intensity at 1:320 dilution) using multivariable logistic regression.ResultsSamples from 16 of 176 participants were ANA-positive. We found higher levels of TCE exposure (concentrations>17.27 ppm) to be associated with an elevated odds of ANA positivity (OR 4.7, 95% CI 1.3 to 16.8) compared with unexposed controls. This association remained after excluding two subjects with diagnosed autoimmune disease (OR 4.5, 95% CI 1.2 to 16.2). We did not observe an association with ANAs at lower exposure levels.ConclusionsOur findings, to our knowledge the first direct human evidence of an association between TCE exposure and systemic autoimmunity, provide biologic plausibility to epidemiologic evidence relating TCE and autoimmune disease.
Unified f(R) gravity at local scales
Authors: Sharma Vipin Kumar , Verma Murli Manohar 
Published: May 2022

AbstractWe explore the shifted $$f(R) (\propto R^{1+\delta })$$

f

(
R
)

(
∝

R

1
+
δ

)

model with $${\delta }$$
δ
as a distinguishing physical parameter for the study of constraints at local scales. The corresponding dynamics confronted with different geodesics (null and non-null) along with their conformal analog are investigated. For null geodesics, we discuss the light deflection angle, whereas, for non-null geodesics under the weak field limit, we investigate the perihelion advance of the Mercury orbit in f(R) Schwarzschild background, respectively. The extent of an additional force, appearing for non-null geodesics, depends on $$\delta $$
δ
. Such phenomenological investigations allow us to strictly constrain $$\delta $$
δ
to be approximately $${\mathcal {O}}(10^{-6})$$

O
(

10

-
6

)

with a difference of unity in orders at galactic and planetary scales and seem to provide a unique f(R) at local scales. Our results suggest that the present form of the model is suitable for the alternative explanation of dark matter-like effects at local scales.