bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cultural importance, availability, and conservation status of Spanish medicinal plants. Implications for sustainability
Authors: Mateo-Martín Jimena , Benítez Guillermo , Gras Airy , Molina María , Reyes-Garcia Victoria , Tardío Javier , Verde Alonso , Pardo-de-Santayana Manuel 
Published: July 2022

Abstract
The harvest of wild plants with medicinal uses is increasing globally, but we know little of the effects of non-commercial harvesting in their conservation status. Here, we explore the connection between the cultural importance of the 1,376 wild medicinal vascular plants traditionally used in Spain for self-treatment (22% of the autochthonous flora, being 16% endemic) and their availability, conservation, and legal protection status, and discuss the implication of our results for sustainability. A species cultural importance is positively correlated with its abundance (ρ = 0.466) and occupancy area (ρ = 0.495). Only 6% of the wild medicinal plants traditionally used in Spain are fully or largely affected by protection measures. Most species used for self-treatment in Spain are common, highly available, and not threatened. This suggests that domestic use does not lead to overexploitation, and proves the sustainability of this knowledge system.
Forecasting of In Situ Electron Energy Loss Spectroscopy
Authors: Spurgeon Steven , Lewis Nicholas , Jin Yicheng , Tang Xiuyu , Shah Vidit , Doty Christina , Matthews Bethany , Akers Sarah 
Published: July 2022

Abstract
Forecasting models are a central part of many control systems, where high consequence decisions must be made on long latency control variables. These models are particularly relevant for emerging artificial intelligence (AI)-guided instrumentation, in which prescriptive knowledge is needed to guide autonomous decision-making. Here we describe the implementation of a long short-term memory model (LSTM) for forecasting of electron energy loss spectroscopy (EELS) data, one of the richest analytical probes of materials and chemical systems. We describe key considerations for data collection, preprocessing, training, validation, and benchmarking, showing how this approach can yield powerful predictive insight into order-disorder phase transitions. Finally, we comment on how such a model may integrate with emerging AI-guided instrumentation for powerful high-speed experimentation.
The Benefit of Low-Level Light Therapy in Association with Intense Pulsed Light for Meibomian Gland Dysfunction
Authors: Marques João Heitor , Marta Ana , Baptista Pedro Manuel , Almeida Daniel , José Diana , Sousa Paulo , Barbosa Irene 
Published: July 2022

Abstract
Purpose
To study the clinical benefit of low-level light therapy when associated with intense pulsed light for the treatment of meibomian gland dysfunction.
Methods
An observational comparative study. Sixty-two (62) subjects were assigned 1:1 to one of two treatment arms: group 1 (31 subjects, 62 eyes), intense pulsed light followed by low-level light and group 2 (31 subjects, 62 eyes) intense pulsed light alone. In both groups, treatments were performed in 3 sessions and subjects were evaluated at baseline and 3 weeks after the last treatment session. Values are shown as Δ = mean difference ± standard deviation.
Results
We observed a significant improvement is OSDI-12 score and lipid layer thickness, in both groups (Δ=-22.7 ± 17.5, p < 0.001 in group 1 and Δ=-23.6 ± 23.8, p < 0.001 in group 2 for OSDI and Δ=+18.6 ± 37.0, p < 0.001 in group 1 and Δ=+19.9 ± 26.4, p < 0.001 in group 2 for lipid layer thickness). Despite no differences between groups at baseline (p = 0.469), only group 1 had a significant improvement in Schirmer test (Δ = + 1.6 ± 4.8, p = 0.009 in group 1 and Δ=+1.7 ± 6.9, p = 0.057 in group 2). No significant side effects were noted. No patient in any group felt subjectively “worse” after the treatment.
Conclusion
Intense pulsed light seems effective and safe for the treatment of meibomian gland dysfunction, improving symptoms and the tear film lipid layer. This study shows no strong evidence of the benefit of low-level light, but it shows weak evidence that it may further improve aqueous tear production.
Utilization of Moringa oleifera seeds as a biosorbent for diclofenac removal in the contaminated aquatic systems
Authors: Damásio Fernanda Queiroz , Costa Bruno Elias dos Santos , Paniágua Cleiseano Emanuel da Siva , Coelho Luciana Melo , Coelho Nivia Maria Melo 
Published: July 2022

Abstract
During recent years, pharmaceuticals and their metabolites have been increasingly found in water bodies and diclofenac is one of the pharmaceuticals residues most frequently detected thus far. The aim of this work was to evaluate the Moringa oleifera seeds as an alternative for diclofenac (DCF) removal in water samples. The batch procedure for DCF removal at the optimized conditions (25 mL of 10.0 mg L−1 DCF, pH 5.0, extraction time of 30 min and M. oleifera mass of 2.0 grams) achieved adsorption of 100% of DCF in real water samples. The pseudo-second-order kinetic described the adsorption rate-controlling step. The adsorption isotherms were fitted by Langmuir, Freundlich and Sips models and the sorption capacity of the biosorbent is spontaneously favourable. The maximum adsorptive capacity was estimated at 32.05 mg g−1 and 32.85 mg g−1 by Langmuir and Sips models, respectively. The advantages of this procedure include good reproducibility in the removal of DCF even at low concentrations in real samples and does not require an additional step of pre-treatment of the adsorbent. The results highlight the potential of M. oleifera seeds as a cheap, environmentally friendly alternative for the removal of DCF from polluted water.
Effect of hydrodynamic condition on algae control based on montmorillonite modified lime-ceramic sand-lake sediments
Authors: Xia Ting , Wang Shi-qi , Yan Hang , Gao Zai-zhuang , Qiu Yao , Yuan Fang , Huang Guang-yong , Zhou Jun 
Published: July 2022

Abstract
Montmorillonite modified lime-ceramic sand-lake sediment (LC-sediments) was synthesized and its algae removal efficiency was investigated in this study. Montmorillonite not only improved the morphology and surface area of original LC-sediments, but also promoted the algal removal rate due to its inherent properties such as accumulating an electric charge, acting as a flocculant, and displaying a local bridging effect. Based on parameter optimization including the ratio of raw materials, agent dosage, initial algae density, pH and a determination of overlying water, the effect of hydrodynamic conditions on the algal removal process was researched. Under the optimal condition, the removal rates of turbidity, algae density and chlorophyll a could reach 86, 88 and 68%, respectively. As verified with a response surface model, it was shown that low disturbance (stirring) of the algae could promote algal removal by montmorillonite modified LC-sediment. Furthermore, a water column was utilized to approximatively simulate the flocculation and algae control in shallow lakes. This study solved the problem of reducing the dosage of lake sediment and improving the removal efficiency of algae without causing secondary pollution to the environment. It was expected to provide a certain theoretical basis for clay flocculation-based algae control in a real environment.
Adsorption of nitrate from interflow by the Mg/Fe calcined layered double hydroxides
Authors: Chu Liquan , Zhang Chaojie , Yu Jing , Sun Xu , Zhou Xuefei , Zhang Yalie 
Published: July 2022

Abstract
Nitrate loss in interflow caused serious nitrate pollution of neighboring water bodies in the purple soil region of China's Sichuan Province. In this study, Mg/Fe(Al)-calcined layered double hydroxides (Mg/Fe(Al)-CLDHs) with varied Mg/Fe(Al) ratios were synthesized for nitrate removal from interflow, and 3:1 Mg/Fe CLDH exhibited the best adsorption performance. The effects of initial pH, adsorbent dosage and co-existing anions on the adsorption performance were investigated by batch experiments. The best-fitting kinetic and isothermal models for nitrate adsorption were the pseudo-second-order model and Freundlich model, respectively, indicating that the adsorption process was a physical-chemical multilayer process. The maximum adsorption capacity of nitrate was 73.36 mg/g, which was higher than that of many other commonly used adsorbents. The adsorbents were characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), transmission electron microscope (TEM) and Brunauer–Emmett–Teller (BET) techniques, and the XRD and FT-IR results revealed that the adsorption mechanism involved original layered structure reconstruction and ion-exchange interaction. Under the coexistence of SO42− and Cl−, 75.63% nitrate in interflow could be removed after 6 h of adsorption. Overall, the synthesized Mg/Fe CLDH is an effective and low-cost nitrate adsorbent for in-situ nitrate removal.
Non-surgical In Vivo Germ Cell-mediated Gene Editing by CRISPR
Mutagenic Chain Reaction with the Aid of Magnetic Nanoparticles
Authors: Lasemi Maryam Vahdat , Sahebkar Amirhossein 
Published: July 2022

Abstract:
Gene therapy via germline cells leads to a permanent genetic modification.
The promise of this method is due to its potential for providing a stable therapeutic effect
for all who inherit the gene of interest. If germinal therapy is successfully performed, it
can eliminate certain diseases from the family and the population. The feasibility of genetic
modification in the human germline raises several controversial and bioethical issues.
However, gene transfer via male and female germinal cells has been recently explored
in animal models. Previous studies have shown that delivering DNA to the testes
followed by electroporation is relatively successful in producing germline-mediated alterations.
Since this method includes surgical procedures, non-surgical, safer, and less time--
consuming methods would be ideal. Herein, we discuss a potential approach for nonsurgical
in vivo germ cell-mediated gene editing by CRISPR mutagenic chain reaction with
the aid of magnetic nanoparticles.
Ethosome Containing Ceramide as a Skin Carrier of Active Ingredients
Authors: Hyeon Tong-Il , Yoon Kyung-Sup 
Published: July 2022

Background:
Numerous formulations have been utilized in the cosmetic and pharmaceutical
industries to effectively deliver bioactive ingredients.

Methods:
We selected a well-known liposomal formulation of bilayer lipid vesicles composed of
ceramide NP. Ethosomes contain hydrophilic vanillic acid or lipophilic α-bisabolol, and their physicochemical
properties were evaluated. Vanillic acid is encapsulated in the aqueous core while α-bisabolol
is engaged with the lipid phase. The formulation was prepared by the high-pressure homogenization
method at 800 bar for 5 min. The particle size, polydispersity index and zeta potential of the ethosome
dispersion were analyzed by dynamic light scattering. In order to measure the skin absorption efficiency
from artificial skin, an in vitro assay was performed using the Franz diffusion cell method for 24 hours.
In addition, ultracentrifuges for encapsulation efficiency, dialysis membranes for active ingredient release,
and low-temperature transmission electron microscopy (TEM) to evaluate the morphology of
vesicles were utilized.

Results:
The particle size of the ethosome containing ceramide NP and vanillic acid was in the range of
80 ~ 130 nm, whereas the particle size of the ethosome containing ceramide NP and α-bisabolol was
150 ~ 170 nm. In the vanillic acid-containing ethosome, increasing the amount of ceramide NP decreased
the particle size, whereas the size of the α-bisabolol ethosome did not change. The stability of
the prepared ethosome did not change significantly for 4 weeks at 25°C, 4°C, and 45°C. The skin absorption
efficiency of ceramide NP and vanillic acid-containing ethosome was increased by about 15%
compared to the control group, whereas the ethosome containing α-bisabolol and ceramide NP showed
slightly higher skin absorption efficiency than the control group. In addition, encapsulation efficiency
evaluation, active ingredient release measurement and cryo-TEM were taken.

Conclusion and Perspective:
Based on the results of these studies, we suggest that ethosome formulations
containing ceramide NP can be widely used in the cosmetic industry together with other cosmetic
formulations.
The Association Between Telemedicine Use and Changes in Health Care Usage and Outcomes in Patients With Congestive Heart Failure: Retrospective Cohort Study
Authors: Chu Cherry , Stamenova Vess , Fang Jiming , Shakeri Ahmad , Tadrous Mina , Bhatia R Sacha 
Published: July 2022

Background
Telemedicine use has become widespread owing to the COVID-19 pandemic, but its impact on patient outcomes remains unclear.

Objective
We sought to investigate the effect of telemedicine use on changes in health care usage and clinical outcomes in patients diagnosed with congestive heart failure (CHF).

Methods
We conducted a population-based retrospective cohort study using administrative data in Ontario, Canada. Patients were included if they had at least one ambulatory visit between March 14 and September 30, 2020, and a heart failure diagnosis any time prior to March 14, 2020. Telemedicine users were propensity score–matched with unexposed users based on several baseline characteristics. Monthly use of various health care services was compared between the 2 groups during 12 months before to 3 months after their index in-person or telemedicine ambulatory visit after March 14, 2020, using generalized estimating equations.

Results
A total of 11,131 pairs of telemedicine and unexposed patients were identified after matching (49% male; mean age 78.9, SD 12.0 years). All patients showed significant reductions in health service usage from pre- to postindex visit. There was a greater decline across time in the unexposed group than in the telemedicine group for CHF admissions (ratio of slopes for high- vs low-frequency users 1.02, 95% CI 1.02-1.03), cardiovascular admissions (1.03, 95% CI 1.02-1.04), any-cause admissions (1.03, 95% CI 1.02-1.04), any-cause ED visits (1.03, 95% CI 1.03-1.04), visits with any cardiologist (1.01, 95% CI 1.01-1.02), laboratory tests (1.02, 95% CI 1.02-1.03), diagnostic tests (1.04, 95% CI 1.03-1.05), and new prescriptions (1.02, 95% CI 1.01-1.03). However, the decline in primary care visit rates was steeper among telemedicine patients than among unexposed patients (ratio of slopes 0.99, 95% CI 0.99-1.00).

Conclusions
Overall health care usage over time appeared higher among telemedicine users than among low-frequency users or nonusers, suggesting that telemedicine was used by patients with the greatest need or that it allowed patients to have better access or continuity of care among those who received it.
Prediction of Specific Anxiety Symptoms and Virtual Reality Sickness Using In Situ Autonomic Physiological Signals During Virtual Reality Treatment in Patients With Social Anxiety Disorder: Mixed Methods Study
Authors: Chun Joo Young , Kim Hyun-Jin , Hur Ji-Won , Jung Dooyoung , Lee Heon-Jeong , Pack Seung Pil , Lee Sungkil , Kim Gerard , Cho Chung-Yean , Lee Seung-Moo , Lee Hyeri , Choi Seungmoon , Cheong Taesu , Cho Chul-Hyun 
Published: July 2022

Background
Social anxiety disorder (SAD) is the fear of social situations where a person anticipates being evaluated negatively. Changes in autonomic response patterns are related to the expression of anxiety symptoms. Virtual reality (VR) sickness can inhibit VR experiences.

Objective
This study aimed to predict the severity of specific anxiety symptoms and VR sickness in patients with SAD, using machine learning based on in situ autonomic physiological signals (heart rate and galvanic skin response) during VR treatment sessions.

Methods
This study included 32 participants with SAD taking part in 6 VR sessions. During each VR session, the heart rate and galvanic skin response of all participants were measured in real time. We assessed specific anxiety symptoms using the Internalized Shame Scale (ISS) and the Post-Event Rumination Scale (PERS), and VR sickness using the Simulator Sickness Questionnaire (SSQ) during 4 VR sessions (#1, #2, #4, and #6). Logistic regression, random forest, and naïve Bayes classification classified and predicted the severity groups in the ISS, PERS, and SSQ subdomains based on in situ autonomic physiological signal data.

Results
The severity of SAD was predicted with 3 machine learning models. According to the F1 score, the highest prediction performance among each domain for severity was determined. The F1 score of the ISS mistake anxiety subdomain was 0.8421 using the logistic regression model, that of the PERS positive subdomain was 0.7619 using the naïve Bayes classifier, and that of total VR sickness was 0.7059 using the random forest model.

Conclusions
This study could predict specific anxiety symptoms and VR sickness during VR intervention by autonomic physiological signals alone in real time. Machine learning models can predict the severe and nonsevere psychological states of individuals based on in situ physiological signal data during VR interventions for real-time interactive services. These models can support the diagnosis of specific anxiety symptoms and VR sickness with minimal participant bias.

Trial Registration
Clinical Research Information Service KCT0003854; https://cris.nih.go.kr/cris/search/detailSearch.do/13508
Training Scenario Development on Environmental Education Using The STSE Model to Improve Positive Attitudes of Prospective Early Childhood Education Teachers towards The Environment
Authors: Muazar Habibi MA 
Published: July 2022

The purpose of this research is to develop training scenarios on environmental education using Science, Technology, Society, Environment (STSE) model integrated into scientific thematic lessons, particularly for prospective early childhood teachers. In addition, product efficiency on the positive attitudes of the trainers towards the environment was examined. The above-mentioned objectives are possibly achieved with the following activities: 1) initializing the Borg Gall model (1999) and 2) assessing the resulting product value using t-test, termed pre-test and post-test. Therefore, the applied simulations were declared suitable for use after series of developmental events.The results involved three expert assessments in the field of early childhood, environmental education, and educational technology, although further analysis is required. Subsequent investigation conducted on the subject user group, indicating a positive value of 83.3%, in support of the product.Therefore, the efficiency test results showed the training on environmental education using the STSE model and integrated with scientific thematic lessons, were known to enhance 32.44% of all aspects of the prospective teacher's positive attitudes on the environment.
Evaluasi Respon Kelompok Tani dalam Kegiatan Introduksi Budidaya Gandum
Authors: Prihtanti Tinjung Mary 
Published: July 2022

Kebijakan pengembangan gandum mulai dirintis pemerintah Indonesia sejak tahun 1980-an saat Kementerian Pertanian mulai melakukan penelitian uji adaptasi gandum. Meski 30 tahun upaya pengembangan telah dilakukan, tetapi budidaya gandum tidak pernah menjadi tanaman penting dalam sistem usaha tani petani di Indonesia. Pengabdian ini bertujuan mengetahui respon kelompok tani terhadap introduksi gandum di lapangan. Analisis respon mengambil kasus dari kegiatan pengabdian masyarakat yakni introduksi budidaya tanaman gandum dilakukan di Desa Ngadirojo, Kecamatan Ampel, Kabupaten Boyolali di tahun 2018 dan di Desa Wates, Kecamatan Getasan, Kabupaten Semarang di tahun 2019. Analisis menggunakan pendekatan kualitatif dengan informan kunci yakni petani yang aktif dalam kegiatan pengabdian masyarakayt baik terlibat dalam budidaya gandum maupun tahap lain yang dilakukan. Hasil observasi kegiatan menunjukkan bahwa aspek relative advantage menjadi titik kritis dalam program introduksi gandum di tingkat kelompok tani, introduksi dengan pendekatan kelompok cukup efisien karena memungkinkan adanya umpan balik dari anggota kelompok tani dan memberi kesempatan bertukar pengalaman, dan faktor kepemimpinan ketua kelompok tani mempengaruhi respon positif dan keterlibatan anggota kelompok tani dalam kegiatan pengabdian masyarakat introduksi gandum.
Fragmenta latina operis Isaaci Ninivitae II: códs. 406 e 593 da Biblioteca do Sacro Convento de São Francisco de Assis
Authors: Cambraia César Nardelli 
Published: July 2022

Este trabalho tem como objetivo continuar a iniciativa de dar a conhecer o texto de todos os testemunhos fragmentários da tradução latina da obra de Isaac de Nínive, obra escrita originalmente em siríaco em fins do séc. XVII. Neste estudo, editam-se dois testemunhos pertencentes ao fundo da Biblioteca do Sacro Convento de São Francisco em Assis (Itália): códs. 406 e 593. Adotaram-se critérios de edição paleográfica, a fim de permitir um estudo mais aprofundado desses registros. Uma breve análise da versão desses testemunhos demonstrou que um não foi o modelo para o outro, mas ambos pertencem a um mesmo ramo da tradição.
THE EFFECT OF CURING CONDITION ON COMPRESSIVE STRENGTH IN HIGH STRENGTH CONCRETE
Authors: Hameed Ali 
Published: July 2022

The paper shows the effect of curing condition on compressive strength in high strength concrete in three cases (Group A(moist curing in water for 7 days followed by air curing ) ,Group B(curing until the age test in water) and Group C(curing at high temperature 60ºC±2ºC for six days ) and two types of specimen of cubes (150 x150 and 100 x 100) used in the test age (7,28and 90 day) respectively in four mix proportion (Mix No.1(40 Mpa ,Mix No. 2(fcu 60 Mpa) ,Mix No. 3 (fcu 70 Mpa) and Mix No. 4 (fcu 80 Mpa) ). Results demonstrate that, in general, concrete specimens moist cured until testing ages (Group B) give compressive strength greater than specimens moist cured for 7 days in water then followed by air – drying (Group A). The percentage of increase in strength is (5 and12%) for mix No.3 and 6% for mix No.4, as compared with 3% for mix No.1 and (2 and4%) for mix No.2. When the curing temperature (group C ) increases, the compressive strength increases at different ratios ,the percentage of increase in compressive strength at 7,28 and 90 days for mix No.1 , mixes No.2 and 3 are (20,15 and 14% ), ( 7,11 and 5% ) and (13,12 and 5% ) respectively, while mix No4. shows an increase of 4 and 10% in compressive strength at 7 and 28 days where there is a reduction in the strength at 90 days by about 2%. Generally, as the size of specimen decreases, the effect of temperature curing (group C)on the compressive strength increases.