bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimated Number of People Who Inject Drugs in the United States
Authors: Bradley Heather , Hall Eric W , Asher Alice , Furukawa Nathan W , Jones Christopher M , Shealey Jalissa , Buchacz Kate , Handanagic Senad , Crepaz Nicole , Rosenberg Eli S 
Published: July 2022

Abstract

Background
Public health data signal increases in the number of people who inject drugs (PWID) in the United States during the past decade. An updated PWID population size estimate is critical for informing interventions and policies aiming to reduce injection-associated infections and overdose, as well as to provide a baseline for assessments of pandemic-related changes in injection drug use.

Methods
We used a modified multiplier approach to estimate the number of adults who injected drugs in the United States in 2018. We deduced the estimated number of nonfatal overdose events among PWID from 2 of our previously published estimates: the number of injection-involved overdose deaths and the meta-analyzed ratio of nonfatal to fatal overdose. The number of nonfatal overdose events was divided by prevalence of nonfatal overdose among current PWID for a population size estimate.

Results
There were an estimated 3 694 500 (95% confidence interval [CI], 1 872 700–7 273 300) PWID in the United States in 2018, representing 1.46% (95% CI, .74–2.87) of the adult population. The estimated prevalence of injection drug use was highest among males (2.1%; 95% CI, 1.1–4.2), non-Hispanic Whites (1.8%; 95% CI, .9–3.6), and adults aged 18–39 years (1.8%; 95% CI, .9–3.6).

Conclusions
Using transparent, replicable methods and largely publicly available data, we provide the first update to the number of people who inject drugs in the United States in nearly 10 years. Findings suggest the population size of PWID has substantially grown in the past decade and that prevention services for PWID should be proportionally increased.
Semantic-Based Hybrid Query Reformulation for Biomedical Information Retrieval
Authors: Selmi Wided , Kammoun Hager , Amous Ikram 
Published: July 2022

Abstract
Query reformulation is a well-known technique intended to improve the performance of Information Retrieval Systems. Among the several available techniques, Query Expansion (QE) reformulates the initial query by adding similar terms, drawn from several sources (corpus, knowledge resources), to the query terms in order to retrieve more relevant documents. Most QE methods are based on the relationships between the original query term and candidate terms (new terms) in order to select the most similar expansion terms. In this paper, we suggested a new hybrid query reformulation through QE and term re-weighting techniques. The suggested approach aimed to demonstrate the effectiveness of QE with a semantic selection of candidate terms according to the specificity of original query terms in the improvement of retrieval performance. To this end, we exploited both relationships defined by knowledge resources and the distributed semantics, recently revealed by neural network analysis. For term re-weighting, we proposed a new semantic method based on semantic similarity measure that assigns a weight to each term of the expanded query. The conducted experiments on OHSUMED and TREC 2014 CDS test collections, including long and short queries, yielded significant results that outperformed the baseline and state-of-the-art approaches.
Modified Multi-Key Fully Homomorphic Encryption Scheme in the Plain Model
Authors: Xu Wenju , Wang Baocang , Qu Quanbo , Zhou Tanping , Duan Pu 
Published: July 2022

Abstract
Multi-key fully homomorphic encryption (MFHE) supports arbitrary meaningful computations on encrypted data under different public keys even without access to the secret key, which is well tailored for the secure multiparty computation scenarios. Based on the Gentry–Sahai–Waters scheme (a single-key FHE in Crypto 2013) with the underlying learning with errors problem, MW16 scheme (Eurocrypt 2016) utilizes the method of ‘linear combination procedure’ (LCP) as a subroutine to construct the auxiliary information for the expanded ciphertexts of MFHE scheme. However, every party shares a common random string (CRS) to be distributed by a trusted setup, which is unpractical. Meanwhile, the noise in the auxiliary information is too much compared with the one in fresh ciphertexts. In this paper, we propose a modified MFHE scheme in the plain model, i.e. without CRS, to enhance the practicability of MFHE. Specifically, every involved party generates his own public key independent on a CRS. Then a potential improvement on the LCP is developed to provide auxiliary information, which largely reduces the noise and leads to a smaller modulus for our MFHE. Furthermore, the feasibility of our proposal is also proved by theoretical performance comparisons.
Prediction of Li-Ion Battery Discharge Patterns in IoT Devices Under Random Use Via Machine Learning Algorithms
Authors: Gökçen Ahmet , Gökçen Alkım , Şahin Savaş 
Published: July 2022

Abstract
This study presents foreseeing of the Lithium-ion battery discharge models for the Internet of Things (IoT) devices under randomized use patterns. IoT systems run in harmony with the human–machine interface, communication protocols and sharing data so long as uninterrupted data communication is exploited for their devices. Hence, forecasting the battery discharge duration is a very important issue for the regularization of IoT device performances. The well-known discharge duration is generally about the age-related electrochemical phenomena of an electrochemistry for Lithium-ion battery. The discharge changes of the battery were obtained from the input–output dynamics of the random battery use obtained from the randomized battery usage dataset in the NASA Ames prognostics data repository. They were investigated by machine learning methods and their results were estimated for life expectancy regularization of the IoT devices. In order to find the appropriate models of battery usage under randomized patterns, artificial neural network (ANN), Gaussian process and nonlinear regression models are evaluated in terms of battery capacity and internal resistance change as a function of discharged energy. The ${R}^2$, Adjusted ${R}^2$, root-mean-square-error (RMSE) and normalized-mean-square-error (NMSE) criteria were used to compare the performances of the obtained models for different settings. According to the results, ANN model, with settings of radial basis function activation function within single hidden-layer, and 20 hidden-layer neurons, shows the best performance in terms of ${R}^2=1.0000$ and $\mathrm{NMSE}={\mathrm{1.7384.10}}^{-4}$ metrics. $\mathrm{RMSE}={\mathrm{0.9896.10}}^{-4}$ is achieved by the ANN model with the settings of single hidden-layer with 10 neurons and hyperbolic-tangent activation function.
The Self-Determination Inventory: Student Report American Sign Language Translation
Authors: Garberoglio Carrie Lou , Gerasimova Daria , Shogren Karrie A , Palmer Jeffrey Levi , Johnson Paige M , Ryan Claire , Pace Jesse R , Hicks Tyler , Millen Kaitlyn , Higgins Jennifer , Cawthon Stephanie W 
Published: July 2022

Abstract
Research literature and community narratives both emphasize the importance of self-determination in the lives of deaf youth. This paper describes the development, initial validation, and potential applications of a translated measure of self-determination for deaf youth, the SDI:SR ASL Translation (SDI:SR ASL). A sample of 3,309 young people who completed the SDI:SR, of whom 392 were deaf, was used in this validation study. Results provide preliminary support for the use of SDI:SR ASL with deaf youth. Findings also indicate that deaf youth who take the SDI:SR ASL score more similarly to youth without disabilities taking the SDI:SR than youth with disabilities. The SDI:SR ASL can be an important tool for researchers and practitioners to better understand self-determination among deaf youth and facilitate continued development of self-determination skills.
Histologic response to steroids in eosinophilic esophagitis is dependent on delivery compound
Authors: Schupack Daniel A , Johnson Kimberly , Akambase Joseph A , Geno Debra , Lavey Crystal , Lennon Ryan J , Ravi Karthik , Snyder Diana L , Katzka David A , Alexander Jeffrey A 
Published: July 2022

Summary
Topical steroids are commonly used in treatment of eosinophilic esophagitis (EoE), but currently there is lack of data to clarify most effective regimen. We aimed to study the achievement of histologic remission using the same dose of budesonide in two different delivery formulations. Patients with established EoE treated with pharmacy compounded budesonide capsule or budesonide Rincinol gel (both 3 mg twice daily) were studied retrospectively. Those with pre-treatment and post-treatment histologic assessment were included with main endpoint being histologic remission. 103 patients (62 gel, 41 capsule) were included, with higher rate of histologic remission with gel (84 vs. 59%, P=0.004). A subset of patients in both groups had lack of steroid response (&lt;50% drop in eosinophils) (15% for gel, 32% for capsule). Formulation/delivery vehicle of steroid treatments to esophageal mucosa in EoE appears important for treatment efficacy, with budesonide gel having higher likelihood of histologic remission compared to budesonide capsules in our population. A truly steroid refractory group appears likely in our population. Larger, prospective studies may help clarify best regimen of topical steroids in EoE and may work to identify patients likely to benefit from alternative therapies.
Symptoms classically attributed to laryngopharyngeal reflux correlate poorly with pharyngeal reflux events on multichannel intraluminal impedance testing
Authors: Salgado Sanjay , Borges Lawrence F , Cai Jennifer X , Lo Wai-Kit , Carroll Thomas L , Chan Walter W 
Published: July 2022

Summary
Laryngopharyngeal reflux (LPR) is thought to be a common etiology of throat and airway symptoms. Diagnosis of LPR is challenging, given the variable symptomatology and response to therapy. Identifying symptoms that better correlate with LPR may inform management strategies. We aimed to examine the association between patient-reported symptoms and objectively identified LPR on ambulatory reflux monitoring. This was a retrospective cohort study of consecutive adults with suspected LPR undergoing combined hypopharyngeal–esophageal multichannel intraluminal impedance–pH testing (HEMII-pH) at a tertiary center. All patients completed standardized symptom surveys for presenting symptoms, reflux symptom index (RSI), and voice handicap index (VHI). LPR was defined as &gt;1 full-column pharyngeal reflux event on HEMII-pH over 24 hours. Univariate and multivariable analyses were performed. A total of 133 patients were included (mean age = 55.9 years, 69.9% female). Of this 83 (62.4%) reported concomitant esophageal symptoms. RSI and VHI did not correlate with proximal esophageal or pharyngeal reflux events (Kendall’s tau correlations P &gt; 0.05), although the mean RSI was higher in the LPR group (21.1 ± 18.9 vs. 17.1 ± 8.3, P = 0.044). Cough, but not other laryngeal symptoms, was more common among patients with esophageal symptoms (58% vs. 36%, P = 0.014). Neither laryngeal symptoms nor esophageal symptoms of reflux predicted LPR on univariate or multivariable analyses (all P &gt; 0.05). Neither laryngeal symptoms classically attributed to LPR nor typical esophageal symptoms correlated with pharyngeal reflux events on HEMII-pH. Clinical symptoms alone are not sufficient to make an LPR diagnosis. Broad evaluation for competing differential diagnoses and objective reflux monitoring should be considered in patients with suspected LPR symptoms.
Blood biomarkers as predictors of pathological lymph node metastasis in clinical stage T1N0 esophageal squamous cell carcinoma
Authors: Ohsawa Manato , Hamai Yoichi , Emi Manabu , Ibuki Yuta , Kurokawa Tomoaki , Yoshikawa Toru , Hirohata Ryosuke , Kitasaki Nao , Okada Morihito 
Published: July 2022

Summary
Accurate preoperative evaluation of lymph node (LN) metastasis is important for determining the treatment strategy for superficial esophageal cancer. Blood biomarkers, such as the neutrophil–lymphocyte, platelet–lymphocyte, and lymphocyte–monocyte ratios (NLR, PLR, and LMR, respectively), have clinical applications as predictors of LN metastasis for different cancers. Here, we investigated the use of these ratios as predictors of pathological LN metastasis and prognosis in patients with clinical stage T1N0M0 esophageal squamous cell carcinoma (ESCC). Patients (n = 185) with cT1N0M0 ESCC who underwent esophagectomy with R0 resection between April 2003 and August 2021 were enrolled. We investigated the ability of pretreatment NLR, PLR, and LMR to predict pathological LN metastasis. The optimal cutoff values of NLR, PLR, and LMR to predict pathological LN metastasis were 2.1, 122, and 4.8, respectively. Univariate and multivariate analyses revealed that the primary tumor length, depth of invasion, and NLR were significant predictors of LN metastasis. Furthermore, similar to the 5-year overall survival, the 5-year relapse-free survival was significantly better in the low NLR group than in the high NLR group. The NLR was the most useful predictor of pathological LN metastasis. Patients diagnosed with clinical stage I ESCC and with a high NLR require adequate LN dissection and may be good candidates for preoperative adjuvant therapy.
PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells
Authors: Gerlach Katharina , Popp Vanessa , Wirtz Stefan , Al-Saifi Ragheed , Gonzalez Acera Miguel , Atreya Raja , Dregelies Theresa , Vieth Michael , Fichtner-Feigl Stefan , McKenzie Andrew N J , Rosenbauer Frank , Weigmann Benno , Neurath Markus F 
Published: July 2022

AbstractBackground and AimsColorectal cancer [CRC] is one of the most frequent malignancies, but the molecular mechanisms driving cancer growth are incompletely understood. We characterised the roles of the cytokine IL-9 and Th9 cells in regulating CRC development.MethodsCRC patient samples and samples from AOM/DSS treated mice were analysed for expression of IL-9, CD3, and PU.1 by FACS analysis and immunohistochemistry. IL-9 citrine reporter mice, IL-9 knockout mice, and PU.1 and GATA3 CD4-Cre conditional knockout mice were studied in the AOM/DSS model. DNA minicircles or hyper-IL-6 were used for overexpression of cytokines in vivo. Effects of IL-6 and IL-9 were determined in organoid and T cell cultures. Claudin2/3 expression was studied by western blotting and bacterial translocation by FISH.ResultsWe uncovered a significant expansion of IL-9- and PU.1-expressing mucosal Th9 cells in CRC patients, with particularly high levels in patients with colitis-associated neoplasias. PU.1+ Th9 cells accumulated in experimental colorectal neoplasias. Deficiency of IL-9 or inactivation of PU.1 in T cells led to impaired tumour growth in vivo, suggesting a protumoral role of Th9 cells. In contrast, GATA3 inactivation did not affect Th9-mediated tumour growth. Mechanistically, IL-9 controls claudin2/3 expression and T cell-derived IL-6 production in colorectal tumours. IL-6 abrogated the anti-proliferative effects of IL-9 in epithelial organoids in vivo. IL-9-producing Th9 cells expand in CRC and control IL-6 production by T cells.ConclusionsIL-9 is a crucial regulator of tumour growth in colitis-associated neoplasias and emerges as potential target for therapy.
The Long-Run Effects of Peers on Mental Health
Authors: Kiessling Lukas , Norris Jonathan 
Published: July 2022

Abstract
This paper studies how peers in school affect students’ mental health. Guided by a theoretical framework, we find that increasing students’ relative ranks in their cohorts by one standard deviation improves their mental health by 6% of a standard deviation conditional on own ability. These effects are more pronounced for low-ability students, persistent for at least 14 years and carry over to economic long-run outcomes. Moreover, we document a pronounced asymmetry: Students who receive negative rather than positive shocks react more strongly. Our findings therefore provide evidence on how the school environment can have long-lasting consequences for individuals’ well-being.
Assessing heat stress tolerance in Castanea sativa
Authors: Dorado F Javier , Solla Alejandro , Alcaide Francisco , Martín M Ángela 
Published: July 2022

Abstract
Increasing temperatures and heat waves decimate the productivity and survival of valuable trees like the European chestnut (Castanea sativa Miller). The main objectives of this study were to assess variation in heat stress tolerance within and between chestnut populations, select molecular markers associated with heat stress tolerance, and to use the selected markers to explore the adaptive potential of C. sativa to tolerate heat stress. Forty-eight trees from three Spanish wild chestnut populations of contrasting climate characteristics were used. Seven out of 20 expressed sequence tag- simple sequence repeat (EST-SSR) markers were selected. To validate the markers, progenies of the 48 trees were subjected to heat stress for 7 days and their heat tolerance was assessed through morphological and physiological changes. Leaf proline content induced by heat was highest in the least thermophilic population. Genetic structure analysis of populations revealed a cluster that included 81 per cent of the seedlings of the most thermophilic population. Signatures of positive selection for heat stress tolerance were detected using VIT099 and POR016 markers, associated with the antioxidant response of plants to heat damage. These markers should be included as candidates for their use in early selection of individuals tolerant to heat stress in C. sativa. Molecular and physiological findings converged in this study to better understand chestnut adaptation to global warming.
Induction and inhibition of Drosophila X chromosome gene expression are both impeded by the dosage compensation complex
Authors: Meisel Richard P , Asgari Danial , Schlamp Florencia , Unckless Robert L 
Published: July 2022

Abstract
Sex chromosomes frequently differ from the autosomes in the frequencies of genes with sexually dimorphic or tissue-specific expression. Multiple hypotheses have been put forth to explain the unique gene content of the X chromosome, including selection against male-beneficial X-linked alleles, expression limits imposed by the haploid dosage of the X in males, and interference by the dosage compensation complex on expression in males. Here, we investigate these hypotheses by examining differential gene expression in Drosophila melanogaster following several treatments that have widespread transcriptomic effects: bacterial infection, viral infection, and abiotic stress. We found that genes that are induced (upregulated) by these biotic and abiotic treatments are frequently under-represented on the X chromosome, but so are those that are repressed (downregulated) following treatment. We further show that whether a gene is bound by the dosage compensation complex in males can largely explain the paucity of both up- and downregulated genes on the X chromosome. Specifically, genes that are bound by the dosage compensation complex, or close to a dosage compensation complex high-affinity site, are unlikely to be up- or downregulated after treatment. This relationship, however, could partially be explained by a correlation between differential expression and breadth of expression across tissues. Nonetheless, our results suggest that dosage compensation complex binding, or the associated chromatin modifications, inhibit both up- and downregulation of X chromosome gene expression within specific contexts, including tissue-specific expression. We propose multiple possible mechanisms of action for the effect, including a role of Males absent on the first, a component of the dosage compensation complex, as a dampener of gene expression variance in both males and females. This effect could explain why the Drosophila X chromosome is depauperate in genes with tissue-specific or induced expression, while the mammalian X has an excess of genes with tissue-specific expression.
Apomixis: genetic basis and controlling genes
Authors: Xu Yuantao , Jia Huihui , Tan Chunming , Wu Xiaomeng , Deng Xiuxin , Xu Qiang 
Published: July 2022

Abstract
Apomixis is the phenomenon of clonal reproduction by seed. As apomixis can produce clonal progeny with exactly the same genotype as the maternal plant, it has an important application in genotype fixation and accelerating agricultural breeding strategies. The introduction of apomixis to major crops would bring many benefits to agriculture, including permanent fixation of superior genotypes and simplifying the procedures of hybrid seed production, as well as purification and rejuvenation of crops propagated vegetatively. Although apomixis naturally occurs in more than 400 plant species, it is rare among the major crops. Currently, with better understanding of apomixis, some achievements have been made in synthetic apomixis. However, due to prevailing limitations, there is still a long way to go to achieve large-scale application of apomixis to crop breeding. Here, we compare the developmental features of apomixis and sexual plant reproduction and review the recent identification of apomixis genes, transposons, epigenetic regulation, and genetic events leading to apomixis. We also summarize the possible strategies and potential genes for engineering apomixis into crop plants.
Vitamin D Supplementation and Antibiotic Use in Older Australian Adults: An Analysis of Data From the D-Health Trial
Authors: Pham Hai , Waterhouse Mary , Baxter Catherine , Duarte Romero Briony , McLeod Donald S A , Armstrong Bruce K , Ebeling Peter R , English Dallas R , Hartel Gunter , Kimlin Michael G , O’Connell Rachel L , van der Pols Jolieke C , Venn Alison J , Webb Penelope M , Whiteman David C , Neale Rachel E 
Published: July 2022

Abstract

Background
Vitamin D supplementation may reduce the risk or severity of infection, but this has been investigated in few large population-based trials. We analyzed data from the D-Health Trial, using prescription of antibiotics as a surrogate for infection.

Methods
The D-Health Trial is a randomized, double-blind, placebo-controlled trial in which 21 315 Australians aged 60–84 years were randomized to 60 000 IU of supplementary vitamin D3 or placebo monthly for 5 years. For this analysis, the primary outcome was the number of antibiotic prescription episodes; secondary outcomes were total number of prescriptions, repeat prescription episodes, and antibiotics for urinary tract infection. We estimated incidence rate ratios (IRRs) using negative binomial regression, and odds ratios using logistic regression.

Results
Vitamin D supplementation slightly reduced the number of prescription episodes (IRR, 0.98; 95% confidence interval [CI], .95–1.01), total prescriptions (IRR, 0.97; 95% CI, .93–1.00), and repeat prescription episodes (IRR, 0.96; 95% CI, .93–1.00). There was stronger evidence of benefit in people predicted to have insufficient vitamin D at baseline (prescription episodes IRR, 0.93; 95% CI, .87–.99).

Conclusions
Vitamin D may reduce the number of antibiotic prescriptions, particularly in people with low vitamin D status. This supports the hypothesis that vitamin D has a clinically relevant effect on the immune system.

Clinical Trials Registration
Australian New Zealand Clinical Trials Registry: ACTRN12613000743763. https://www.anzctr.org.au/.