bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Getting our voices heard in research: a review of peer researcher’s roles and experiences on a qualitative study of adult safeguarding policy
Authors: Montgomery Lorna , Kelly Berni , Campbell Ursula , Davidson Gavin , Gibson Leanne , Hughes Louise , Menham Jadzia , McKendry Linda , Newton Leslie-Anne , Parkinson Alex , Redmond Ethan , Turnbull Joseph , Webb Paul , Wood Lisamarie 
Published: November 2022

Abstract
Background
Historically, disabled people have been marginalised in research that traditionally adopted a medical model perspective. Since the 1970’s, there has been a shift from research on disabled people to research with disabled people with a strong emphasis on co-produced participatory research. Co-production involves disabled people working with academics to produce research and outcomes which are informed by the end user. This paper reflects on the role and experiences of peer researchers in co-producing a recent UK-wide research project called ‘Getting our Voices Heard’. This project sought to identify the best approaches for people with a learning disability and their supporting organisations to influence adult safeguarding policies, across the four jurisdictions of the UK.

Methods
A co-produced participatory design was used to address the project aims; achieved through the establishment of a collaborative research team comprising academic researchers, key stakeholders and six peer researchers, each of whom had a learning disability. Semi-structured interviews were completed with senior policy makers. Following this, in each of the four Nations, an organisational case-study was completed (four in total). Organisations were purposively sampled to identify one organisation in each country which was recognised as being successful in influencing adult safeguarding policy. Data were gathered through focus groups discussions and semi-structured interviews with key stakeholders. Findings were developed into an Impact Strategy and Action Plan. Co-production methods were used throughout.

Results
Six individuals with a learning disability were recruited and trained to work as peer researchers, involved at key stages of the project, working alongside a wider research team. The role and experiences of the peer researchers in the context of policy are presented. Peer researchers provided largely positive first-hand accounts of their experiences. The importance of collaboration, the invaluable role of Learning Disability support organisations, and the need for additional time and resources to facilitate co-production, was noted.

Conclusion
Whilst peer researchers were positive about their experiences, some success in promoting co-produced research and areas for improvement were evident. Collaboration at all stages would have been strengthened with research funding which enabled involvement of all team members in all research activities.
Verification of nanoparticle formation, skin permeation, and apoptosis using nobiletin as a methoxyflavonoid derivative
Authors: Inoue Yutaka , Ishizawa Moe , Itakura Shoko , Tanikawa Takashi , Todo Hiroaki 
Published: November 2022

AbstractPurposeNobiletin (NOB), a polymethoxyflavonoid, is known for its antioxidant and anti-inflammatory effects and has antitumor activity. However, its poor solubility and low bioavailability pose a significant challenge in its delivery. In this experiment, NOB was added to Soluplus® (Sol)/l-ascorbyl 2,6-dipalmitate (ASC-DP) as a ternary system, and Sol/ASC-DP/NOB nanoparticles were obtained using the hydration method. The purpose of this study was to enhance the solubility of NOB, apply it for skin permeation, and improve antitumor activity.MethodsThe preparation of Sol/ASC-DP/NOB nanoparticles was attempted using the hydration method, and particle size, zeta potential, and stability tests were performed to evaluate the formation of nanoparticles. 1H-1H NOESY/ROESY NMR spectral measurements were also performed to identify molecular interaction between NOB and Sol/ASC-DP. To evaluate its functionality, DPPH radical scavenging, skin permeation, fluorescence microscopy, and cell viability analyses were performed.ResultsThe particles were approximately 100 nm in size in the ternary system (weight ratio (Sol/ASCDP/NOB=8/1/1)) and were relatively stable for approximately 7 days at 25 °C under light-shielded conditions. From the NMR spectrum measurements of Sol/ASCDP/NOB, a cross-peak was observed between the –OCH3 group: C6,8 (3.8 ppm) derived from NOB, the methyl group (2.0 ppm) derived from Sol, and the side chain portion (1.2 ppm) derived from ASC-DP. Cross-peaks were observed between the polyethylene glycol (PEG) backbone of Sol (3.6 ppm) and the side chain of ASC-DP (0.8–1.2 ppm). The formation of Sol/ASC-DP/NOB nanoparticles facilitated its skin permeation, and fluorescence microscopy confirmed improved permeation. The DPPH radical scavenging test revealed that Sol/ASC-DP/NOB had an IC50of 46.7 μg/mL. Cell viability assays showed a 20–40% decrease in cell viability with the addition of Sol/ASC-DP/NOB at 0.1 mg/mL.ConclusionSol/ASC-DP/NOB nanoparticles were successfully prepared, and these were found to inhibit melanin formation and have antitumor activity.
Rare sites of metastases in patients with differentiated thyroid carcinoma and added value of SPECT/CT over planar whole body radioactive iodine scan
Authors: Bashank Nahla , Farghaly Hussein , Hassanein Sara , Abdel-Tawab Mohamed , Wahman Mohamed , Mahmoud Hemat 
Published: November 2022

Abstract
Background
Being aware of the unusual or rare location of thyroid metastases helps in early diagnosis and proper patient management. Rare metastases (RM) can be missed resulting in diagnostic pitfalls and delayed treatment. The use of single-photon emission computed tomography/computed tomography (SPECT/CT) imaging in the follow-up of differentiated thyroid cancer (DTC) patients provides precise anatomical localization and characterization of RM that may be missed or misinterpreted in planar whole body iodine-131 (WBI) scan. There is a lack of knowledge about dealing with such patients, the treatment they should receive, and therapy response due to the rarity of such cases. In this work, we reported these rare cases increasing awareness about them and their methods of treatment with response to therapy and evaluated the added value of SPECT/CT imaging in changing patients’ management.

Materials and methods
In this study we reviewed all patients with DTC referred to our unit either for initial radioactive iodine-131 therapy (RAIT) or under follow-up from January 2019 to January 2022. When a suspected lesion was detected in a conventional planar WBI scan whether follow-up scan or post-therapeutic scan, SPECT/CT was acquired immediately in the same session for that region. Additional imaging modalities were performed for confirmation. Response to the given treatment either disease progression (DP) or favorable response which include complete response (CR), partial regression (PR) and stable disease (SD) recorded for each patient.

Results
Two hundred and forty patients with DTC referred to our unit over a three-year period (from January 2019 to January 2022) were reviewed. Forty patients developed lung and bone distant metastases. Twenty-one patients were thought to have metastases at unusual sites. Due to incomplete data (no SPECT/CT pictures or confirmatory imaging), 6/21 patients were eliminated. We studied 15 patients with RM (9 females, 6 males) with a median age of 52 years (range 27–79). All patients received the initial RAIT after thyroidectomy in addition to other therapeutic modalities, e.g., radiotherapy (RTH), chemotherapy (CTH) or surgical tumor excision after detection of RM. Ten out of 15 patients (66.67%) showed favorable response to therapy (2 patients had CR, 6 patients had PR and 2 patients had SD), whereas only 5 patients had DP. Additional SPECT/CT changed management in 10/15 patients (66, 67%) of patients.

Conclusion
RM identification is mandatory to avoid misdiagnosis and delayed therapy. Increasing the awareness about such rare cases allows for better management. SPECT/CT could significantly impact patients' management through its precise anatomic localization and lesion characterization.
Frequency of non-thyroidal illness syndrome in pediatric patients with sepsis and septic shock
Authors: Abdelgawad Tarek Ahmed , Magdy Sondos Mohamed , Mahmoud Rana Abdelhakaim Ahmed , Taha Sara Ibrahim Abdelfatah , Ali Safaa Yossef Abd Elhameed 
Published: November 2022

AbstractBackgroundNon-thyroidal illness syndrome (NTIS) is considered when patients demonstrate altered thyroid hormones and is frequently seen in patients with sepsis and septic shock. Levels keep affected with disease progression and usually get normalized after the sickness is cured. NTIS is not studied well in pediatric population.Aim of the workOur primary outcome was to assess the frequency of hormonal changes of NTIS in sepsis and septic shock patients. The secondary outcome was to follow-up the severity of NTIS and its effect on the prognosis of the primary illness.Patients and methodsThis study (1st phase: cross-sectional, 2nd phase: prospective) included 40 critically ill children categorized into two groups: (i) sepsis group: defined according to standard international criteria using pediatric Sequential Organ Failure Assessment (p SOFA) score and sepsis was considered when p SOFA score > 2; (ii) septic shock group: defined by a vasopressor requirement to maintain a mean arterial pressure ≥ 65 mmHg and having a serum lactate level > 2 mmol/L despite adequate fluid resuscitation, with 20 patients in each group. Patients were admitted to the pediatric intensive care unit (PICU). Thyroid hormone levels were assessed and compared in day 1 and day 5 in all patients and subgroups. All patients were followed up until discharge or death.ResultsNTIS was found in 47.5% of patients. NTIS was higher among septic shock group than sepsis 65.5% versus 30% (p= 0.027). NTIS was associated with each of ventilation, catecholamines infusion and SOFA score (p= 0.044, 0.027, and 0.033) respectively. FT3 (free triiodothyronine) levels were lower and rT3 (reverse T3) levels were higher in day 5 of sickness than day 1 (p= 0.041 and 0.000) respectively. Furthermore, FT3 levels in day 5 were lower, and rT3 levels in day 1 and day 5 were higher in non-survivors than survivors (p= 0.002, 0.015, and 0.003) respectively. ROC curve was done to assess predictors of mortality and revealed that FT3 levels in day 5 was the best in predicting PICU mortality, followed by SOFA score day 5.ConclusionNTIS is common among critically ill children and higher among septic shock group than sepsis. Also, beside the SOFA score, FT3 measured in day 5 of sickness were the best predictors of PICU mortality.
Prenatal oral health guidelines: a theory- and practice-informed approach to survey development using a modified-Delphi technique and cognitive interviews
Authors: Vamos Cheryl A. , Griner Stacey B. , Daley Ellen M. , Cayama Morgan Richardson , Beckstead Jason , Boggess Kim , Quinonez Rocio B. , Damschroder Laura 
Published: November 2022

AbstractBackgroundPregnancy presents an opportune time for oral health promotion and intervention; however, implementation of the prenatal oral health guidelines remains a challenge among prenatal and oral health providers. The purpose of this study was twofold: To employ a theory-based approach to identify high-priority Consolidated Framework for Implementation Research (CFIR) constructs with the greatest potential to impact prenatal oral health guideline implementation, and to operationalize and pre-test survey items based on the prioritized CFIR constructs. Identifying barriers and facilitators to guideline implementation will inform the development of targeted interventions that address gaps in adherence which can positively impact oral-systemic health.MethodsThe online survey development process employed three rounds of a modified-Delphi technique with prenatal (i.e., MD/DO, CNM) and oral health (i.e., DMD) Practice Advisory Board Members, cognitive interviews with prenatal and oral health providers, and deliberations among the research team and a Scientific Advisory Board (OBGYN, pediatric dentist, and researchers). High-impact CFIR constructs were identified and translated into survey items that were subsequently piloted and finalized.ResultsDuring three modified-Delphi rounds, a total of 39 CFIR constructs were evaluated with final input and deliberations with the Practice Advisory Board, Scientific Advisory Board, and the research team achieving consensus on 19 constructs. The instrument was pre-tested with four prenatal and two oral health providers. Overall, participants reported that the survey items were feasible to respond to, took an appropriate length of time to complete, and were well-organized. Participants identified specific areas of improvement to clarify CFIR items. The final survey instrument included 21 CFIR items across four domains, with five constructs included from the intervention characteristics domain, two from the process domain, two from the outer setting domain, and 12 from the inner setting domain.ConclusionsLessons learned from the survey development process include the importance of soliciting diverse scientific and practice-based input, distinguishing between importance/impact and direction of impact (barrier/facilitator), and the need for additional qualitative methods during interdisciplinary collaborations. Overall, this study illustrated an iterative approach to identifying high-priority CFIR constructs that may influence the implementation of the prenatal oral health guidelines into practice settings.
Symptomatic giant solitary bile cyst with intracystic bleeding in a 13-year-old girl: a case report and literature review
Authors: Junqueira José Otávio Guedes , de Pinho João Henrique Sendrete , de Oliveira Junqueira Thaís Bandeira , de Oliveira Junqueira Bruna Bandeira , Vidigal Fernando Mendonça , Furtado Maria Cristina Vasconcelos , de Souza Gláucio Silva 
Published: November 2022

Abstract
Background
Simple hepatic cyst is a rare disease in childhood. They occur in the general population with a prevalence of up to 5%. The incidence and size of cysts increase dramatically in adults older than 50 years. We performed a systematic literature review of all cases of simple hepatic cysts in the pediatric population undergoing surgical treatment. We found 52 cases reported in literature with a mean age of 2.54 years, 15% were pedicled cysts and only one case reported intracystic bleeding, detected only in the anatomopathological examination. We report a case of a 13-year-old girl who was presented with a symptomatic giant solitary bile cyst, the second biggest simple hepatic cyst reported in pediatric population, the biggest pedicled cyst and the only case of intracystic bleeding detected in pre-operative image examination in this group. This case brings important considerations about this complication and its pre-operative diagnosis.

Case presentation
We report a case of a 13-year-old girl with a giant solitary biliary cyst in the left hepatic lobe, symptomatic and with intracystic bleeding noted on magnetic resonance imaging. Diagnosis was difficult due to nonspecific symptoms and the non-typical images of simple hepatic cyst due to intracystic bleeding. The patient underwent a laparotomy, showing a large pedicled cyst, linked to segments II and III without adherence to other organs. Complete excision of the lesion was performed because the risk of torsion. The postoperative period passed without complications.

Conclusions
Although intracystic bleeding is the most common complication in adults, this is not reported in the pediatric population according to our review. Knowing how to recognize intracystic bleeding is important, because this complication predisposes the cyst to rupture and changes the appearance of the lesion on imaging tests, which can be more easily confused with cystadenoma or a cystadenocarcinoma. The magnetic resonance imaging is essential in the intracystic bleeding investigation. Comparisons between ultrasound and computed tomography findings associated with anemia history can prove the probability of this complication.
Unused opioid prescription prevalence after pediatric ambulatory surgery: a survey study
Authors: Dixit Anjali A. , Ho Nhi , Inglis-Arkell Christina , Chen Catherine L. , Ferschl Marla , Manuel Solmaz P. 
Published: November 2022

Abstract
Background
Surgery is a risk factor for opioid initiation, persistent use, and subsequent misuse in pediatric patients. The objective of this study was to assess the rate of postoperative opioid prescribing and extent of unused opioid prescriptions on the first postoperative day after pediatric ambulatory surgery.

Methods
A telephone survey was administered on postoperative day 1 (POD1) to guardians of all pediatric patients who underwent ambulatory surgery at a single medical center. Participants were asked whether postoperative opioids were prescribed, and, if yes, whether they were currently taking them. Multivariable logistic regression was used to assess factors associated with postoperative opioid prescribing and unused opioids on POD1.

Results
Of 1344 pediatric patients who underwent ambulatory surgical procedures, 849 (63.1%) guardians responded to the survey. 275 (32.4%) were prescribed postoperative opioids, and 164 (59.6%) reported not taking opioids on POD1. The highest rates of unused opioid prescriptions were from orthopedic and plastic surgery services (28% and 29%, respectively). Governmental insurance status predicted having unused opioids (OR 0.59, CI 0.35–0.97).

Conclusions
Unused opioid prescriptions were prevalent in this pediatric ambulatory surgical population. Opportunities remain to streamline opioid prescribing in pediatric patients undergoing ambulatory surgical procedures.
Co-infection of fasciolosis and hydatidosis and their financial loss in cattle slaughtered at Wolaita Sodo municipal abattoir, southern Ethiopia
Authors: Fesseha Haben , Asefa Isayas 
Published: November 2022

AbstractFasciolosis and hydatidosis are the world’s most common zoonotic major parasitic ailments of domesticated animals with financial and public health implications. A cross-sectional study was conducted on 384 randomly selected cattle slaughtered at Wolaita Sodo municipal abattoir to estimate the prevalence and associated risk factors for co-infection of hydatidosis and fasciolosis using the ante- and postmortem examination techniques. Of the 384 examined cattle, 4.17% were found to harbor co-infections of hydatidosis and fasciolosis. Similarly, the prevalence of concurrent fasciolosis and hydatidosis infections was 76.56% and 23.44% in local and crossbred animals, respectively. The current study took into account risk factors such as age, breed, origin, and body condition score; however, there is a statistically insignificant association between the risk factors and the prevalence of concurrent fasciolosis and hydatidosis infection. In this study, overall fasciolosis was recorded at a rate of 9.38%, with the highest prevalence of F. hepatica at 8.59%, followed by unidentified flukes at 4.17% and F. gigantica at 0.78%. Likewise, the single prevalence of hydatidosis was recorded at 10.94%. Of the 142 examined cysts, the liver alone harbors 54 cysts, and the lung alone harbors 88 cysts, with a total of 43 calcified, 21 sterile, 56 viable, 9 nonviable, and 13 mixed cysts. The predicted yearly financial loss from organ condemnation was 15,436,142.00 ETB Birr. This study demonstrated that hydatidosis and fasciolosis are two relatively widespread parasite diseases of cattle in Ethiopia, causing significant economic loss attributable to organ rejection and indirect weight loss. Thus, awareness of the impact of the disease on the community could disrupt the parasite’s life cycle, and its economic significance was forwarded to other points.
The interactions between vitamin D and neurofilament light chain levels on cognitive domains in bipolar disorder
Authors: Chen Wen-Yin , Huang Ming-Chyi , Chiu Chih Chiang , Cheng Ying-Chih , Kuo Chian-Jue , Chen Po-Yu , Kuo Po-Hsiu 
Published: November 2022

Background
Bipolar disorder is a chronic mental disorder related to cognitive deficits. Low serum vitamin D levels are significantly associated with compromised cognition in neuropsychiatric disorders. Although patients with bipolar disorder frequently exhibit hypovitaminosis D, the association between vitamin D and cognition in bipolar disorder, and their neuroaxonal integrity, is unclear.

Aims
To investigate the interaction effects between vitamin D and neurofilament light chain (NfL) levels on cognitive domains in bipolar disorder.

Method
Serum vitamin D and NfL levels were determined in 100 euthymic patients with bipolar disorder in a cross-sectional study. Cognitive function was measured with the Brief Assessment of Cognition in Affective Disorders. We stratified by age groups and used general linear models to identify associations between vitamin D and NfL levels and their interaction effects on cognitive domains.

Results
The mean vitamin D and NfL levels were 16.46 ng/nL and 11.10 pg/mL, respectively; 72% of patients were vitamin D deficient. In the older group, more frequent hospital admissions and lower physical activity were identified in the group with versus without vitamin D deficiency. The age-modified interaction effect of vitamin D and NfL was associated with composite neurocognitive scores and verbal fluency in both age groups, and with processing speed domain in the younger group.

Conclusions
We observed a high vitamin D deficiency prevalence in bipolar disorder. We identified the interaction of vitamin D and NfL on cognitive domains, and the effect was modified by age. Longitudinal or randomised controlled studies enrolling patients with various illness durations and mood statuses are required to validate our findings.
The Black Englishmen of Old Calabar
Authors: Mbah Ndubueze L. 
Published: November 2022

AbstractThis article recovers the Afropolitan histories of Liberated Africans by examining their mobility and freedom politics. Liberated Africans enacted Afropolitanism when they returned from Sierra Leone to Old Calabar and fashioned themselves into Black Englishmen. Their Afropolitanism incorporated a dissident mode of Anglo-cosmopolitanism, thereby undermining orthodox British visions of imperial subjecthood. In using petitions to British authorities to assert their identity as British subjects, they secured their precarious freedom but challenged British monopoly of the Bight of Biafra’s transatlantic palm oil trade. Rather than being mere recipients of abolition, Liberated Africans refashioned abolition. They used forged “freedom papers” to emancipate, repossess, and traffic slaves from Old Calabar society while defending their behavior as “redemption” of slaves. Contrary to imperial fixity of African subjects, Liberated Africans evinced an Afropolitan vision of belonging. They simultaneously claimed to be natives of Sierra Leone and Old Calabar. Their contradictory ideologies and practices mitigated their marginality and confounded African elites and British imperial agents.
Urban Iconographies
Authors: Fulton Dawn 
Published: November 2022

AbstractThis article examines literary evocations of Afropolitanism in French, with particular attention to millennial works by Black women writers. Narratives and portraits by Lauren Ekué, Léonora Miano, and Rokhaya Diallo reject the Afro-pessimism of twentieth-century visions of urban migration by foregrounding the consumerism and cultural capital of their female protagonists. Rethinking Paris as a stage rather than a site, these works present new models of Afropolitan iconography, featuring women who are eminently alert to the contradictions and contingencies of contemporary Black experience. In teasing out the links among presentism, hip-hop culture, and the European beauty industry, these explorations generate a unique brand of performed consumerism that forges a dialogue between Black female cosmopolitanism and historicity.