bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rotor Topology to Reach Beyond IE5 Ultra-Premium Efficiency in Line Start Permanent Magnet Synchronous Motor
Authors: P Sethupathi , Senthilnathan N. , Atshaya M. 
Published: September 2022

Abstract
Emerging efficiency standards indicates the demand of implementing highly efficient motors to reduce energy consumption and global warming, which is a worldwide concern. Owing to this, IE4 Efficiency line start permanent magnet synchronous motors (LSPMSM) contribution is increasing to a greater extent in the industrial motor market. This paper presents a new rotor configuration for a 2.2kW, 4 pole LSPMSM which is designed to meet efficiency beyond IE5 along with good power factor. The steady state and transient performance of the motor is optimized by using finite element analysis (FEA) software. From the results, it is evident that the proposed motor meets beyond IE5 efficiency level with 10% reduction in its length. Further reducing the length up to 30%, the motor sustains at IE4 efficiency level. To illustrate the optimum performance of the proposed design, the performance of the motor is benchmarked with identical radial type LSPMSM and commercially available IE2 induction motor. The FEA results of the proposed design are validated with the prototype development and testing. Consequently, this topology is both technically competent and cost effective, particularly for round the clock operation.
The inhibition of putrescine synthesis affects the in vitro shoot development of Cedrela fissilis Vell. (Meliaceae) by altering endogenous polyamine metabolism and the proteomic profile
Authors: Aragão Victor Paulo Mesquita , de Sousa Kariane Rodrigues , de Oliveira Tadeu Dos Reis , de Oliveira Leandro Francisco , Floh Eny Iochevet Segal , Silveira Vanildo , Santa-Catarina Claudete 
Published: September 2022

Abstract
Polyamines (PAs) and proteins have been demonstrated to be fundamental for in vitro shoot development of Cedrela fissilis. We evaluated the influence of 6-benzyladenine (BA) and putrescine (Put) on the growth of shoots, PA metabolism and proteomic profiles of C. fissilis.The longest shoots were obtained under 2.5 μM BA + 2.5 mM Put treatment. The inhibition of Put synthesis by D-arginine (D-arg) reduced the activities of the Put biosynthesis enzymes arginine decarboxylase (ADC) and ornithine decarboxylase (ODC) and the endogenous contents of free Put, resulting the reduced shoot growth. The ODC activity was higher than that ofADC, which is the main enzyme in the synthesis of Put in C. fissilis. Inhibition of Put synthesis affected the proteomic profile, reducing the accumulation of the ubiquitin receptor RAD23c, peroxidase 15, ADP-ribosylation factor 1, ADP-ribosylation factor-like protein 8a, profilin-4, profilin-2, glucan endo-1,3-beta-glucosidase, and expansin-like B1 and increasing the accumulation of V-type proton ATPase catalytic subunit A and methionine gamma-lyase, highlighting the relevance of these proteins in promoting the length of shoots. Moreover, the transport protein SEC13 homolog B and the basic isoform glucan endo-1,3-beta-glucosidase, unique proteins in shoots treated with BA+Put, were related to the promotion of shoot growth. Our results show that the modulation of endogenous PAs and proteomic profiles is necessary to regulate in vitro morphogenesis in C. fissilis. Moreover, the ODC enzyme is highly involved in the synthesis of Put during in vitro shoot development and is described for the first time in this species.
Expanding the Legionella pan-kinome
Authors: Krysińska Marianna , Baranowski Bartosz , Deszcz Bartłomiej , Pawłowski Krzysztof , Gradowski Marcin 
Published: September 2022

Abstract
The pathogenic Legionella bacteria are notorious for delivering numerous effector proteins into the host cell with the aim of disturbing and hijacking cellular processes for their benefit. Despite intensive studies, many effectors remain uncharacterized. Motivated by the richness of Legionella effector repertoires and their oftentimes atypical biochemistry, also by several known atypical Legionella effector kinases and pseudokinases, we undertook an in silico survey and exploration of the pan-kinome of the Legionella genus, i.e., the union of the kinomes of individual species. In this study, we discovered 13 novel (pseudo)kinase families (all are potential effectors) with the use of non-standard bioinformatic approaches. Together with 16 known families, we present a catalog of effector and non-effector protein kinase-like families within Legionella. We analyze and discuss the likely functional roles of the novel predicted kinases. Notably, some of the kinase families are also present in other bacterial taxa, including other pathogens, often phylogenetically very distant from Legionella. This work highlights Nature's ingeniousness in the pathogen–host arms race and offers a useful resource for the study of infection mechanisms.
Demographic and socio-economic factors influencing financial preparedness and the level of preparedness of salaried women in India
Authors: Radhakrishnan Sreeja , N Suresh V , Johnson Merin 
Published: September 2022

Abstract
People spend more than what they have and when it comes to saving money, most of the people save whatever is left over after consumption, without a proper budget for household, a proper goal, proper allocation of income, and proper understanding of investment avenues. Saving for retirement is harder for the present generation as the financial sector is overwhelmed with choices and specifically, women have little or no understanding about these investment avenues. As circumstances differ, women are experiencing dearth of financial wellbeing. The covid-19 crisis has increased the uncertainties and triggered the financial stress. This study brings insight into the financial preparedness level of women especially salaried and the influence of various demographic factors on financial preparedness. The questionnaire used for the study was developed through a series of steps and was further tested for reliability and validity. Statistical Package for Social Sciences (SPSS) 20.0 version was used for preliminary analysis of data and Analysis of Moment Structures Software-18 graphics (AMOS) were used for Confirmatory Factor Analysis and Structural Equational Modelling along with Microsoft excel 2016 for data entry of 600 respondents and analyzed using Mean, Standard deviation, Mean score analysis one-way Analysis of Variance, Post hoc test. As this research’s main contribution, findings on the level of financial preparedness of salaried women can be of help to those seeking to improve the lives of women. It will provide a foundation for policy formulation, training programmes, pension schemes development for empowering women.
SPOP Expression Is Associated with tumor-infiltrating lymphocytes in Pancreatic Cancer
Authors: Yang Xiaojuan , Xu Yongfeng , Zhu Qing 
Published: September 2022

Abstract

Background: Speckle Type POZ Protein (SPOP), despite its tumor type-dependent role in tumorigenesis, primarily as a tumor suppressor gene is associated with a variety of different cancers. However, its function in pancreatic cancer remains uncertain.
Methods: SPOP expression and the association between its expression and patient prognosis and immune function were evaluated using The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), The Tumor Immune Estimation Resource 2.0 (TIMER2.0) database, cBioportal, and various bioinformatic databases. Enrichment analysis of SPOP and the association between SPOP expression with clinical stage and grade were analyzed using the R software package. Then immunohistochemistry (IHC) was used to estimate the correlation between SPOP and tumor-infiltrating lymphocytes (TILs) in patients with pancreatic cancer.
Results: As part of our study, we assessed that SPOP was anomalously expressed in kinds of cancers, associated with clinical stage and outcomes. Meanwhile, SPOP also played a crucial role in the tumor microenvironment (TME). The expression level of SPOP was significantly correlated to tumor-infiltrating immune cells (TICs) in pancreatic cancer.
Conclusions: Our study uncovered the potential corrections in SPOP with TICs, suggesting that SPOP may act as a biomarker for immunotherapy in pancreatic cancer.
A systematic study on occurrence, risk estimation and health implications of heavy metals in potable groundwater of Garhwal Himalaya, India
Authors: Prasad Mukesh , Aswal R. S. , Joshi Abhishek , Kumar G. Anil , Ramola R. C. 
Published: September 2022

Abstract
Groundwater is consumed by major part of the population for drinking and other purposes. The occurrence of heavy metals (HMs) in drinking water has been a critical water quality concern for a long time and can compromise its aesthetic value to the larger extent. Chronic exposure of human beingsto these toxic and non-toxic HMs through water ingestion can result in significant health risks.To assess these associated health risks,the present study was planned, designed and carried out for analyses of nine HMs namely Al, Cr, Mn, Co, Ni, Cu, Zn, Cd, and Pb in the potable groundwater samples collected from different sources located across the Mandakini valley of Garhwal Himalaya, India using ICPMS. The observed values of analyzed HMs except Zn and Pb were found below the reference values prescribed by the WHO, USEPA, and BIS. The highvalue of Pb (11.252 µg l− 1 at one site) may be ascribed due to the corrosion of materials contained with lead or copper and household plumbing systemswhile Zn concentration exceeded its MPL (4000 µg l− 1) recommended by WHO for infants only at one station. These observed concentrations were further used to calculate HMs pollution indices to determine water quality based on their classification for assessment of health risks.The observed indicesshow that there are no health risks from HMs contamination via drinking water in the region. Moreover, the estimated hazard quotients for children and adults also revealed no potential health risks.The details of measurement protocols, employed methodology, and the results obtained are discussed below.
A penalized criterion for selecting the number of clusters for K-medians
Authors: Godichon-Baggioni Antoine , Surendran Sobihan 
Published: September 2022

Abstract
Clustering is a usual unsupervised machine learning technique for grouping the data points into groups based upon similar features. We focus here on unsupervised clustering for contaminated data, i.e in the case where K-medians algorithm should be preferred to K-means because of its robustness. More precisely, we concentrate on a common question in clustering: how to chose the number of clusters? The answer proposed here is to consider the choice of the optimal number of clusters as the minimization of a penalized criterion. In this paper, we obtain a suitable penalty shape for our criterion and derive an associated oracle-type inequality. Finally, the performance of this approach with different types of K-medians algorithms is compared on a simulation study with other popular techniques. All studied algorithms are available in the R package Kmedians on CRAN.
EEG Microstate Dynamics Associated with Dream-like Experiences during the Transition to Sleep
Authors: Diezig Sarah , Denzer Simone , Achermann Peter , Mast Fred W. , Koenig Thomas 
Published: September 2022

Abstract
Consciousness always requires some representational content; that is, one can only be conscious about something. However, the presence of conscious experience (awareness) alone does not determine whether its content is in line with the external and physical world. Dreams, apart from certain forms of hallucinations, typically consist of non-veridical percepts, which are not recognized as false, but rather considered real. This type of experiences have been described as a state of dissociation between phenomenal and reflective awareness. Interestingly, during the transition to sleep, reflective awareness seems to break down before phenomenal awareness as conscious experience does not immediately fade with reduced wakefulness but is rather characterized by the occurrence of uncontrolled thinking and perceptual images, together with a reduced ability to recognize the internal origin of the experience. Relative deactivation of the frontoparietal and preserved activity in parieto-occipital networks has been suggested to account for dream-like experiences during the transition to sleep. We tested this hypothesis by investigating subjective reports of conscious experience and large-scale brain networks using EEG microstates in 45 healthy young subjects during the transition to sleep. We observed an inverse relationship between cognitive effects and physiological activation; dream-like experiences were associated with an increased presence of a microstate with sources in the superior and middle frontal gyrus and precuneus. Additionally, the presence of a microstate associated with higher-order visual areas was decreased. The observed inverse relationship might therefore indicate a disengagement of cognitive control systems that is mediated by specific, inhibitory EEG microstates.
Bioinformatic Analysis Revealing Independent Predictors of Poor Prognosis and Immunologic/Metastatic Behaviors in Squamous Cell Lung Cancer
Authors: Yan Jinshan , Na Fangjian , Li Xinyao , Shi Sha , Li Xin , Hao Junli , Wu Ying , Gang Xiaoyu , Zhao Mingfang 
Published: September 2022

Abstract
Background
Squamous cell carcinoma of the lung (LUSC) is a malignant tumor with a high mortality rate and few treatment options.
Methods
This study explored novel biomarkers and the related mechanisms in LUSC development via integrated bioinformatics analysis based on multiple databases. TCGA-LUSC, GSE30219, and GSE37745 datasets were selected, and univariate Cox analysis was applied to each. The candidate prognostic genes were those survival hazardous genes that overlapped in the three datasets and were further applied in Kaplan-Meier log-rank test. Receiver-operating characteristics (ROC) curves were made to compare the candidate prognostic genes’ predictive accuracy and traditional clinicopathological parameters (CPPs). Moreover, fast preranked gene set enrichment analysis, single-sample gene set enrichment analysis, gene set variation analysis, and correlation analysis was sequentially performed to explore the candidate prognostic genes’ potential functions.
Results
Based on the data for stage I–III LUSC, aldehyde dehydrogenase 7 family member A1 (ALDH7A1), progestogen-associated endometrial protein (PAEP), and vav guanine nucleotide exchange factor 2 (VAV2) were identified as prognostic candidate biomarkers that could improve the accuracy of traditional CPPs for predicting overall survival (OS). Moreover, ALDH7A1, PAEP, and VAV2 were, respectively, correlated with the immune microenvironment and epithelial–mesenchymal transition (EMT), but not with tumor mutation burden, microsatellite instability, or CPPs. The EMT biomarker vimentin (but not E-cadherin) was consistent with ALDH7A1, PAEP, and VAV2.
Conclusion
This study elucidated the prognostic roles and potential functions of ALDH7A1, PAEP, and VAV2 in LUSC.
“You nearly feel a little bit like you’ve less right to grieve”: A Qualitative Study on the Impact of Cancer on Adult Siblings
Authors: Burke Hazel , Dunne Simon 
Published: September 2022

Abstract
Purpose
Family members of cancer patients experience a range of challenges and are impacted in various ways by the cancer. To our knowledge, the impact of cancer on adult siblings has yet to be explored. Sibling relationships are one of the longest relationships individuals have across the lifespan. Thus, the current study sought to investigate the perspectives of siblings of those who previously had cancer.
Methods
10 participants were recruited using purposive sampling. A qualitative, cross-sectional design was implemented with both virtual and in-person semi-structured interviews. Interviews were audio-recorded, transcribed and analysed using thematic analysis.
Results
The researcher identified five themes relating to both the impact of cancer on siblings and the supports they received: changes in family relationships, sibling’s grief is forgotten, benefits of social support networks, supporting their sibling & caregiving and self-support.
Conclusions
Cancer organizations and support services should focus on signposting services for siblings in order to ensure they can access support. Further research is needed with siblings to gain greater insight into what supports siblings feel are available for them to access, whether there are any for them to access or how supports can be improved.
Implications for Cancer Survivors:
The provision of appropriate psychological support for siblings of cancer patients will ensure they can provide optimal support and care to their siblings. This will in turn benefit cancer patients along their cancer trajectory as adequate support from their caregivers will enhance their quality of life.
Simplification of water distribution networks using non-linear Thevenin theorem and its application for maximum power transfer
Authors: Balireddy Raman , Chakravorty Anjan , Bhallamudi S. Murty , Kuiry Soumendra Nath 
Published: September 2022

Abstract
The boundaries of existing cities are expanding rapidly due to the exponential growth in urban population. Therefore, the existing water distribution networks (WDNs) need to be expanded up to the newly developed areas to meet the additional water demand. The optimal design of a sub-network planned for network expansion requires multiple simulations under various constraints. Simulating the additional sub-network along with the existing network takes a lot of CPU time. In this study, a methodology is proposed to replace an existing large pipe network with its equivalent network consisting of a single source and a single pipe by applying the non-linear Thevenin theorem being used for electrical circuits. The equivalent network model parameters are extracted by fitting the driving-node head-loss characteristics at the connecting node. Unlike all other available methods except the traditionally used reservoir–pump model, the equivalent network presented in this study reduces to only two elements. The theoretical aspect of the reservoir–pump model can be explained by the proposed Thevenin reduction method. The advantage of the proposed method is put forward by deriving an analytical expression for the condition of maximum power transfer from the equivalent main network to the sub-network. The economic diameter value of the connecting pipe is subsequently determined. The proposed network reduction method is demonstrated on different WDNs for various demand patterns. The reduced networks yield accurate results and simulate faster when compared with those of the original networks. The proposed methodology is beneficial for a focused analysis of a sub-network and to transfer maximum power to the sub-network connected to a large existing hydraulic network.
Effectiveness of tetrahydrofuran at enhancing the 1,4-dioxane degradation ability of activated sludge lacking prior exposure to 1,4-dioxane
Authors: Inoue Daisuke , Hisada Kazuki , Ike Michihiko 
Published: September 2022

Abstract
1,4-dioxane (DX) is a contaminant of emerging concern in water environments. The enrichment of DX-degrading bacteria indigenous to activated sludge is key for the efficient biological removal of DX in wastewater. To identify an effective substrate, which enables the selective enrichment of DX-degrading bacteria and has lower toxicity and persistence than DX, this study explored the effectiveness of tetrahydrofuran (THF) at enhancing the DX degradation ability of activated sludge without historical exposure to DX. Although the activated sludge initially exhibited negligible ability to degrade DX (100 mg-C/L) as the sole carbon source, the repeated batch cultivation on THF could enrich bacterial populations capable of degrading DX, inducing the DX degradation ability in activated sludge as effectively as DX did. The THF-enrichment culture after 4 weeks degraded 100 mg-C/L DX almost completely within 21 d. Sequencing analyses revealed that soluble di-iron monooxygenase group 5C, including THF/DX monooxygenase, would play a dominant role in the initial oxidation of DX in THF-enrichment culture, which completely differed from the enrichment culture cultivated on DX. The results indicate that THF can be applied as an effective substrate to enhance the DX degradation ability of microbial consortia, irrespective of the intrinsic ability.
2-Nucleobase-substituted 4,6-Diaminotriazine Analogs: Synthesis and
Anti-cancer Activity in 5-Fluorouracil-sensitive and Resistant Colorectal
Cancer Cells
Authors: Hamze Khalil , Abdallah Rola H. , Younis Nour K , Fardoun Manal , Darwiche Nadine , Kobeissy Firas , Iratni Rabah , Bouhadir Kamal , Eid Ali H. 
Published: September 2022

Background:
Cancer continues to be the second leading cause of death worldwide, with
colorectal cancer (CRC) being the third most common type. Despite significant advances in cancer
therapies, the current treatment of CRC remains suboptimal. In addition, the effectiveness of available
chemotherapeutic drugs such as 5-Fluorouracil (5-FU) is limited by CRC-acquired resistance.

Methods:
In this study, we provide innovative approaches employed in synthesizing four novel nucleobase
analogs. Equally, we describe the effects of these compounds on proliferation, migration,
aggregation, and adhesion of 5-FU-sensitive (HCT116) and -resistant (5-FU-R-HCT116) human
CRC cells. In either cell type, our synthesized novel analogs significantly inhibited cell viability in
a concentration- and time-dependent manner. This highlights the higher potency of these novel
analogs. In addition, these compounds attenuated migration and adhesion of both cell types while
they promoted homotypic cell-cell interaction.

Results:
These changes were reflected by the downregulation of matrix metalloproteases (MMP-2
and MMP-9). Furthermore, our analogs exhibited potent anti-angiogenic activity in vivo.

Conclusion:
These novel nucleobase analogs reduced the level of secreted vascular endothelial
growth factor (VEGF) and nitric oxide (NO) production in both 5-FU-sensitive and -resistant CRC
cells. Taken together, our data highlight the potential chemotherapeutic properties of our novel
analogs against CRC, including the 5-FU-resistant form.
Advances in the Therapeutic Use of Non-Ergot Dopamine Agonists in the
Treatment of Motor and Non-Motor Symptoms of Parkinson’s Disease
Authors: Jing Xiao-Zhong , Yang Hui-Jia , Taximaimaiti Reyisha , Wang Xiao-Ping 
Published: September 2022

Abstract:
Dopamine (DA) agonists, as an excellent dopamine replacement therapy for
patients with early and advanced Parkinson's disease (PD), play a vital role in
controlling motor and several non-motor symptoms. Besides, the application of DA
agonists may delay levodopa therapy and the associated risk of motor complications.
Indeed, each DA agonist has unique pharmacokinetic and pharmacodynamic
characteristics and therefore has different therapeutic efficacy and safety profile. The
comorbidities, significant non-motor manifestations, concomitant medications, and
clinical features of PD individuals should guide the selection of a specific DA agonist
to provide a more patient-tailored treatment option. Thorough knowledge of DA
agonists helps clinicians better balance clinical efficacy and side effects. Therefore,
this review refers to recent English-written articles on DA agonist therapy for PD
patients and summarizes the latest findings on non-ergot DA agonists as well as the
advantages and disadvantages of each compound to help clinicians in the selection of
a specific DA agonist. In addition, novel D1/D5 partial agonists and new formulations
of DA agonists are also discussed.