bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kunraja Media Development (Aksara Jawa Uno Card) On Javanese Script writing Materials In Elementary Schools
Authors: Rofiqoh Nur , Khoirul Umam Nanang , Alfiansyah Iqnatia 
Published: November 2022

This study aims to develop KUNRAJA media on Javanese script writing material in elementary schools in grade III UPT SD Negeri 43 Gresik for the 2020/2021 school year. The process of developing learning media uses the modified and simplified ADDIE model, namely, analysis (Analysis), design (Design), development (Development), implementation (Implementation) and evaluation (Evaluation). The results of the development of learning media in the form of KUNRAJA media contain material for writing Javanese script. Sources of data in this development research are material experts and media experts totaling 4 validators and class III students with a total of 28. The data collection used is the validation of learning media and student learning outcomes tests. With data analysis, namely, analysis of the validity of learning media, analysis of the practicality of learning media and the effectiveness of learning media.
Based on the results of the descriptive analysis of the validation data, it was obtained that the development of the KUNRAJA media on the Javanese script writing material in elementary schools met the good criteria, as follows: a) The results of the validation of learning media conducted by 4 validators obtained a percentage of 100% by material experts 1 and a percentage of 100% by material expert 2 with a total average rating of 100%, and a percentage of 100% by media expert 1 and a percentage of 92.5% by media expert 2 with a total average rating of 96.25% which is categorized as valid and can be used in the learning process, b) Categorized as practical from the results of the analysis in the practicality of learning media by the validators indicating that the media can be used with little or no revision. c) while in the learning outcomes test, students who scored 70 were 28 students with a percentage of 93.1% which was categorized as effective for use in the learning process.
Keywords: ADDIE Model, KUNRAJA, Javanese Script.
The Development of Textbooks On Circumference And Area Of Flat Shapes Material For Grade IV Elementary School
Authors: Handayani Titik , Marzuki Ismail , Umam Nanang Khoirul 
Published: November 2022

The development of this textbook aims to be able to assist students in self-study at home as well as teachers in understanding students, especially in the topic of ​​circumference and area of ​​ two-dimensional figure. This research is a textbook development research using 3 of the 4 steps of the 4D Development Model, namely Define (defining), Design (design), Development (development). The results of the media in the form of Textbooks of the topic Circumference and area of ​​ two-dimensional figure. The data obtained from this study were teacher interviews and validation of learning media. There are four kinds of validation sheets used, namely one for material validation, presentation validation, linguistic validation, and graphic validation. Based on the expert validator's assessment of the Circumference and area of ​​ two-dimensional figure Textbooks for Grade IV Elementary School, the results of the material validator's assessment showed an average value of 90% which was categorized as valid. The results of the language validator show an average value of 91.6% which is categorized as valid. The results of the presentation validator show an average of 85.4% so it is categorized as valid. The results of the graphical validator show an average value of 95.8% which can be categorized as valid. The assessments of the validators can be said as valid with a few revisions or additions to complete the textbook.
Keywords : 4D Model, Textbook, Perimeter and Area, two-dimensional figure
KAJIAN SENI DALAM PROSES UPACARA TINGKEBAN ETNIK JAWA DI KELURAHAN SENDANG MULYA SARI KECAMATAN TONGAUNA KABUPATEN KONAWE
Authors: Wahyuni Dwi , Marafat La Ode Sidu , Nggawu La Ode 
Published: November 2022

Penelitian ini bertujuan untuk (1) untuk menganalisis seni tradisi verbal dan nonverbal dalam upacara Tingkeban Etnik Jawa di Kelurahan Sendang Mulya Sari Kecamatan Tongauna Kabupaten Konawe. (2) untuk menganalisis Prosesi Ritual Upacara Tingkeban yang ada di Kelurahan Sendang Mulya Sari Kecamatan Tongauna Kabupaten Konawe. (3) untuk menganalisis tentang fungsi upacara adat dalam tradisi Tingkeban di Kelurahan Sendang Mulya Sari Kecamatan Tongauna Kabupaten Konawe. Berdasarkan Tesis dapat diketahui bahwa penyelenggaraan upacara tingkeban ini ada beberapa rangkaian yang harus dilaksanakan yaitu : slametan kenduren, siraman, dan sangat. Dalam slametan kenduren banyak dijumpai adanya sesaji uborambe yang mempunyai makna simbolik. Prosesi Siraman banyak ajaran etika dan estetika sebagai pedoman dalam hidup. Dalam sangat harus mencari hari baik untuk pelaksanaan upacara tingkeban. Fungsi upacara tingkeban bagi etnik Jawa adalah sebagai sarana upacara ritual, sebagai sarana sosial, sebagai sarana estetika, dan media pendidikan Kata Kunci:Seni,Upacara,Tingkeban,dan EtnikJawa.
Psychiatric outcomes following ketamine administration for orthopedic surgical anesthesia
Authors: Mansour Alec E. , Hale Elijah W. , Saks Daniel S. 
Published: November 2022

BackgroundKetamine is a non-barbiturate general anesthetic commonly used in a variety of medical settings for pain and sedation. Its use in treatment for psychiatric illnesses has been increasing in recent years, showing promise in reducing depressive and suicidal symptoms in patients, particularly surgical patients. However, it has a history of association with schizophrenia-like and psychotomimetic symptoms following administration, particularly in patient populations with previous mental illness and youths.ObjectiveUsing a retrospective cohort study of patient records from a large health database, we sought to investigate psychiatric outcomes in age-specific cohorts following ketamine administration for orthopedic surgical anesthesia.MethodsThis was a retrospective analysis of the TriNetX health database. We identified all patients undergoing orthopedic surgeries with anesthesia. We then performed four total group analyses between cohorts of patients receiving ketamine and cohorts not receiving ketamine. We had three sets of analysis based on age stratification and one ageless: pediatric (&lt;18 years), adult (18–60 years), elderly (&gt;60 years), and a reference analysis of all patients.ResultsIn 406,384 patients studied, nearly every measured event displayed an increased risk for patients receiving ketamine as part of their anesthesia. Apart from anhedonia, which had a decreased risk of occurrence, every event displayed increased incidence in at least two of the cohorts. For all but one event, nicotine use, the significant differences between groups were in concordance with each other.ConclusionOur findings suggest ketamine use should be investigated further in different age groups and corresponding psychiatric outcomes.
Correlational analysis of three-dimensional spinopelvic parameters with standing balance and gait characteristics in adolescent idiopathic scoliosis: A preliminary research on Lenke V
Authors: Liu Yanan , Li Xianglan , Dou Xiaoran , Huang Zhiguan , Wang Jun , Liao Bagen , Zhang Xiaohui 
Published: November 2022

Background: Adolescent idiopathic scoliosis (AIS), the most common spinal deformity, possibly develops due to imbalanced spinal loading following asymmetric development. Since altered loading patterns may affect standing balance and gait, we investigated whether a correlation exists between balance ability, gait pattern, and the three-dimensional radiographic spinopelvic parameters in AIS patients.Methods: A cross-sectional observational study was conducted with 34 AIS patients (aged 10–18 years) and an equal number of healthy age and sex-matched teenagers (normal group). We obtained the spinopelvic three-dimensional parameters and balance parameters simultaneously through the EOS imaging system and gait and center of pressure (CoP) characteristics using a plantar pressure measurement mat. Besides determining the intergroup differences in balance and gait parameters, multiple linear regression analyses were performed to identify any correlation between the static plantar pressure and radiographic parameters.Results: Compared to the normal group, the CoPx is lower, the CoP path length and 90% confidence ellipse area were significantly higher in AIS patients (AIS: −13.7 ± 5.7 mm, 147.4 ± 58.1 mm, 150.5 ± 62.8 mm2; normal: −7.0 ± 5.4 mm, 78.8 ± 32.0 mm, 92.1 ± 41.7 mm2, respectively), correlated with apical vertebra translation, sagittal pelvic tilt, and pelvis axial rotation, respectively. Moreover, AIS patients had a shorter stance phase (61.35 ± 0.97 s vs. 62.39 ± 1.09 s), a longer swing phase (38.66 ± 0.97 s vs. 37.62 ± 1.08 s), and smaller maximum pressure peaks in the gait cycle, especially on the left foot, as compared to healthy subjects. Moreover, the CoP trajectory in AIS patients was different from the latter, and changes in the bipedal trend were not consistent.Conclusion: The standing balance and gait characteristics of AIS patients are different from those of healthy subjects, as reflected in their three-dimensional spinopelvic radiographic parameters. Trial registration: The study protocol was registered with the Chinese Clinical Trial Registry (Number ChCTR1800018310) and the Human Subject Committee of Guangzhou Sport University (Number: 2018LCLL003).
PAG3 promotes the differentiation of bloodstream forms in Trypanosoma brucei and reveals the evolutionary relationship among the Trypanozoon trypanosomes
Authors: Wen Yan-Zi , Tang Hao-Tian , Cai Xiao-Li , Wu Na , Xu Jia-Zhen , Su Bi-Xiu , Hide Geoff , Lun Zhao-Rong , Lai De-Hua 
Published: November 2022

IntroductionTrypanosoma brucei, T. evansi and T. equiperdum are members of the subgenus Trypanozoon and are highly similar morphologically and genetically. The main differences between these three species are their differentiation patterns in the hosts and the role of vectors in their life cycles. However, the mechanisms causing these differences are still controversial.MethodsPAG3 gene was accessed by PCR amplification in 26 strains of Trypanozoon and sequences were then analyzed by BLAST accompanied with T. evansitype B group. RNA interference and CRISPR/Cas9 were used for revealing possible role of PAG3 in slender to stumpy transformation.ResultsThe procyclin associated gene 3 (PAG3) can be found in the pleomorphicspecies, T.brucei, which undergoes differentiation of slender forms to the stumpy form. This differentiation process is crucial for transmission to the tsetse fly vector. However, a homologue of PAG3 was not detected in either T. evansi or in the majority of T. equiperdum strains which are allmonomorphic. Furthere xperiments in T. brucei demonstrated that, when PAG3 was down-regulated or absent, there was a significant reduction in the differentiation from slender to stumpy forms.ConclusionTherefore, we conclude that PAG3 is a key nuclear gene involved in the slender to stumpy differentiation pathway of T.brucei in the mammalian host. Loss of this gene might also offer a simple evolutionary mechanism explaining why T. evansi and some T. equiperdum have lost the ability to differentiate and have been driven to adapt to transmission cycles that by pass the tsetse vector or mechanical contact.
The “obesity paradox” in patients with atrial fibrillation: Insights from the Gulf SAFE registry
Authors: Li Yan-Guang , Xie Peng-Xin , Alsheikh-Ali Alawi A. , AlMahmeed Wael , Sulaiman Kadhim , Asaad Nidal , Liu Shu-Wang , Zubaid Mohammad , Lip Gregory Y. H. 
Published: November 2022

BackgroundThe prognostic impact of obesity on patients with atrial fibrillation (AF) remains under-evaluated and controversial.MethodsPatients with AF from the Gulf Survey of Atrial Fibrillation Events (Gulf SAFE) registry were included, who were recruited from six countries in the Middle East Gulf region and followed for 12 months. A multivariable model was established to investigate the association of obesity with clinical outcomes, including stroke or systemic embolism (SE), bleeding, admission for heart failure (HF) or AF, all-cause mortality, and a composite outcome. Restricted cubic splines were depicted to illustrate the relationship between body mass index (BMI) and outcomes. Sensitivity analysis was also conducted.ResultsA total of 1,804 patients with AF and recorded BMI entered the final analysis (mean age 56.2 ± 16.1 years, 47.0% female); 559 (31.0%) were obese (BMI over 30 kg/m2). In multivariable analysis, obesity was associated with reduced risks of stroke/systematic embolism [adjusted odds ratio (aOR) 0.40, 95% confidence interval (CI), 0.18–0.89], bleeding [aOR 0.44, 95%CI, 0.26–0.74], HF admission (aOR 0.61, 95%CI, 0.41–0.90) and the composite outcome (aOR 0.65, 95%CI, 0.50–0.84). As a continuous variable, higher BMI was associated with lower risks for stroke/SE, bleeding, HF admission, all-cause mortality, and the composite outcome as demonstrated by the accumulated incidence of events and restricted cubic splines. This “protective effect” of obesity was more prominent in some subgroups of patients.ConclusionAmong patients with AF, obesity and higher BMI were associated with a more favorable prognosis in the Gulf SAFE registry. The underlying mechanisms for this obesity “paradox” merit further exploration.
Machine learning models in heart failure with mildly reduced ejection fraction patients
Authors: Zhao Hengli , Li Peixin , Zhong Guoheng , Xie Kaiji , Zhou Haobin , Ning Yunshan , Xu Dingli , Zeng Qingchun 
Published: November 2022

ObjectiveHeart failure with mildly reduced ejection fraction (HFmrEF) has been recently recognized as a unique phenotype of heart failure (HF) in current practical guideline. However, risk stratification models for mortality and HF re-hospitalization are still lacking. This study aimed to develop and validate a novel machine learning (ML)-derived model to predict the risk of mortality and re-hospitalization for HFmrEF patients.MethodsWe assessed the risks of mortality and HF re-hospitalization in HFmrEF (45–49%) patients enrolled in the TOPCAT trial. Eight ML-based models were constructed, including 72 candidate variables. The Harrell concordance index (C-index) and DeLong test were used to assess discrimination and the improvement in discrimination between models, respectively. Calibration of the HF risk prediction model was plotted to obtain bias-corrected estimates of predicted versus observed values.ResultsLeast absolute shrinkage and selection operator (LASSO) Cox regression was the best-performing model for 1- and 6-year mortality, with a highest C-indices at 0.83 (95% CI: 0.68–0.94) over a maximum of 6 years of follow-up and 0.77 (95% CI: 0.64–0.89) for the 1-year follow-up. The random forest (RF) showed the best discrimination for HF re-hospitalization, scoring 0.80 (95% CI: 0.66–0.94) and 0.85 (95% CI: 0.71–0.99) at the 6- and 1-year follow-ups, respectively. For risk assessment analysis, Kansas City Cardiomyopathy Questionnaire (KCCQ) subscale scores were the most important predictor of readmission outcome in the HFmrEF patients.ConclusionML-based models outperformed traditional models at predicting mortality and re-hospitalization in patients with HFmrEF. The results of the risk assessment showed that KCCQ score should be paid increasing attention to in the management of HFmrEF patients.
Linking land use with riverine water quality: A multi-spatial scale analysis relating to various riparian strips
Authors: Li Siyue , Zhang Jing , Jiang Ping , Zhang Liuqing 
Published: November 2022

Exploring linkages between riverine water quality and land use is of great importance for catchment management and water quality conservation. Relationships between them are complex and site-specific. Therefore, land-use/landscape effects on water quality remain to be investigated. Multivariate statistics and empirical models are used to examine the influences of seasonality (wet and dry seasons), land use in various riparian strips, on water quality seasonality in the river networks of the Three Gorges Reservoir Area. Redundancy analysis (RDA) shows a comparable effect of land use on overall water quality (OWQ) during the two seasons. The variance of OWQ explained is generally higher in the 50 m riparian zone, whilst, the variance is higher along 200 m riparian in the wet season with land use composition presented as actual area. The explanatory variables of land use indices for the OWQ are quite distinct. Multiple linear regression (MLR) modeling indicates that models of water quality parameters (WQPs) depend on seasonality, riparian zone and representation of land use indices (calculated from percentage and actual area), this results in predictor variables of WQPs are highly variable. Land use within the 50 m riparian zone can predict WQPs well, and land use along the riparian zones predicts WQPs better in the dry season. We firstly compared the impacts of multi-riparian land use indices (presented as percentage and actual area) in combination with land use configuration on water quality. Our study provides critical information for efficiently land-use planning to protect water quality.
Biomarkers in psoriatic arthritis: A meta-analysis and systematic review
Authors: Wirth Theo , Balandraud Nathalie , Boyer Laurent , Lafforgue Pierre , Pham Thao 
Published: November 2022

IntroductionPsoriatic arthritis (PsA) is a chronic inflammatory disease that frequently develops in patients with psoriasis (PsO) but can also occur spontaneously. As a result, PsA diagnosis and treatment is commonly delayed, or even missed outright due to the manifold of clinical presentations that patients often experience. This inevitably results in progressive articular damage to axial and peripheral joints and entheses. As such, patients with PsA frequently experience reduced expectancy and quality of life due to disability. More recently, research has aimed to improve PsA diagnosis and prognosis by identifying novel disease biomarkers.MethodsHere, we conducted a systematic review of the published literature on candidate biomarkers for PsA diagnosis and prognosis in MEDLINE(Pubmed), EMBase and the Cochrane library with the goal to identify clinically applicable PsA biomarkers. Meta-analyses were performed when a diagnostic bone and cartilage turnover biomarker was reported in 2 or moredifferent cohorts of PsA and control. ResultsWe identified 1444 publications and 124 studies met eligibility criteria. We highlighted bone and cartilage turnover biomarkers, genetic markers, and autoantibodies used for diagnostic purposes of PsA, as well as acute phase reactant markers and bone and cartilage turnover biomarkers for activity or prognostic severity purposes. Serum cartilage oligometrix metalloproteinase levels were significantly increased in the PsA sera compared to Healthy Control (HC) with a standardized mean difference (SMD) of 2.305 (95%CI 0.795-3.816, p=0.003) and compared to osteoarthritis (OA) with a SMD of 0.783 (95%CI 0.015-1.551, p=0.046). The pooled serum MMP-3 levels were significantly higher in PsA patients than in PsO patients with a SMD of 0.419 (95%CI 0.119-0.719; p=0.006), but no significant difference was highlighted when PsA were compared to HC. While we did not identify any new genetic biomarkers that would be useful in the diagnosis of PsA, recent data with autoantibodies appear to be promising in diagnosis, but no replication studies have been published. ConclusionIn summary, no specific diagnostic biomarkers for PsA were identified and further studies are needed to assess the performance of potential biomarkers that can distinguish PsA from OA and other chronic inflammatory diseases.
Aberrant metabolic processes promote the immunosuppressive microenvironment in multiple myeloma
Authors: Lv Junqiang , Sun Hao , Gong Lixin , Wei Xiaojing , He Yi , Yu Zhen , Liu Lanting , Yi Shuhua , Sui Weiwei , Xu Yan , Deng Shuhui , An Gang , Yao Zhi , Qiu Lugui , Hao Mu 
Published: November 2022

IntroductionMultiple myeloma (MM) is still an incurable plasma cell malignancy. The efficacy of immunotherapy on MM remains unsatisfactory, and the underlying molecular mechanisms still are not fully understood.MethodsIn this study, we delineated the dynamic features of immune cell in MM bone marrow (BM) along with elevated tumor cell infiltration by single-cell RNA sequencing (scRNA-seq), and investigated the underlying mechanisms on dysfunction of immune cells associated with myelomagenesis.ResultsWe found that immune cells were activated in those patients with low infiltration of tumor cells, meanwhile suppressed with elevated infiltration of MM cells, which facilitated MM escaping from immune surveillance. Besides PD-1, abnormal expression of PIM kinases, KLRB1 and KLRC1 were involved in the defect of immune cells in MM patients. Importantly, we found aberrant metabolic processes were associated with the immunosuppressive microenvironment in MM patients. Disordered amino acid metabolism promoted the dysfunction of cytotoxicity CD8 T cells as well as lipid metabolism disorder was associated with the dysregulation of NK and DCs in MM. As metabolic checkpoints, PIM kinases would be potential effective strategies for MM immunotherapy.DiscussionIn summary, redressing the disordered metabolism should be the key points to get promising effects in immune-based therapies.
Transition to bereavement: A prospective longitudinal study of health-related quality of life in informal caregivers of oldest-old individuals
Authors: Alves Sara , Paúl Constança , Ribeiro Oscar 
Published: November 2022

IntroductionExperiencing bereavement may be challenging. Despite the oldest-old population increase, a subgroup at greater risk of death, few studies focus on the grieving process of informal caregivers (ICs). This study analyzed the transition to bereavement of ICs of oldest-old individuals (≥80 years) over 1-year and compares the evolution of the health-related quality of life (HrQoL) between those experiencing bereavement and those who continued care through the study period.Materials and methodsA prospective longitudinal observational study was conducted enrolling 204 ICs of the Metropolitan Area of Porto (North Portugal), of which 36 experienced the death of care receiver (CR). ICs’ health profile and burden were assessed. CRs’ functional and cognitive status were also appraised.ResultsBereaving caregivers were mostly female, CRs’ children, and had on average 60.4 years at baseline. Caregivers spent a mean of 10.1 h/day (SD = 7.7) caring, for 80.6 months (SD = 57.5). The time elapsed since CR’s death was 6 months (SD = 3.5) from entering in the study. CRs who died had a mean age of 88.3 (SD = 5.4) years at baseline, and were very dependent. Over a 1-year follow-up, bereaving caregivers showed a significant decrease in mental health following CR’s death; on the other hand, caregivers who continued caring improved mental health [F(1, 159) = 4.249, p = 0.041].DiscussionEnding the caregiver career was marked by a decline in mental health whereas to continue caring was marked by an improvement in this outcome. While it is highly expected that the CR’s death will be perceived as a relief considering both the caregiver’s characteristics (e.g., medicines) and the CR condition (e.g., high dependence levels), the results suggest an opposite direction. CRs’ death seems to arise an emotional burden for IC, at least during the first year, possibly triggering feelings of loneliness and a life without purpose that seems to aggravate mental health issues.ConclusionThe transition to bereavement among ICs seems to lead to a caregiver mental health decline while those who continued caring (and thereby, experiencing caregiving stressors) seems to improve in this outcome. Ceasing caregiving stressors does not seem to contribute better experiencing bereavement among ICs, suggesting the need for support throughout this phase.