bluuebunny/crossref_metadata_2025_split huggingface dataset:
POTENSI MINYAK KAYU PUTIH (Melaleuca cajuputi) SEBAGAI SUMBER BAHAN AKTIF DALAM PEMBUATAN HAND SANITIZER LIDAH BUAYA
Authors: Nursanti Yuliani  , Sipahelut Sophia Grace , Vita Novalin Lawalata  
Published: October 2022

Hand sanitizer as a medium to maintain hand hygiene is becoming a trend among the community today, especially because of the COVID-19 pandemic. Hand sanitizers with active ingredients of essential oils are considered safer than alcohol. The purpose of this research was to examine the addition of cajuput oil in the manufacture of aloe vera hand sanitizer on the physical quality, antiseptic and organoleptic activity of the hand sanitizer produced. The research design used a completely randomized design (CRD) with one factor, namely the addition of cajuput oil, with five treatment levels, namely 0 mL, 16 mL, 20 mL, 24 mL, and 28 mL with each treatment in three replications. The hand sanitizer produced was then tested for physical characteristics (density, spreadability, pH, and homogeneity), antiseptic activity, and organoleptic characteristics (color, texture, aroma and non-sticky impression). The results showed that the aloe vera hand sanitizer sample with the addition of 28 mL cajuput oil had a stronger antiseptic effectiveness among other samples and had physical characteristics that met the quality requirements of SNI hand sanitizer including pH 7.33, spreadability 6.96 cm, density 1.1546, homogeneous without any coarse grains and organoleptically acceptable and favored by the panelists.
Sleep syncope—A systematic review
Authors: Raj Priya L. , Sheldon Robert S. , Lorenzetti Diane , Jardine David L. , Raj Satish R. , Vandenberk Bert 
Published: October 2022

BackgroundSleep syncope is a subtype of vasovagal syncope in which patients experience syncope after awakening from their sleep. The aim was to investigate the association of clinical characteristics and gastrointestinal symptoms with syncope, as well as the body position in which symptoms began.MethodsA systematic search of studies was performed in MEDLINE and EMBASE without language restrictions, from inception to 9 January 2022. Studies were included if they reported data on the proportion of patients who experienced symptoms (nausea, vomiting, abdominal pain, and diarrhea) associated with syncope.ResultsData were included for 116 patients in 13 studies. Patients were 46.9 ± 4.3 years and 61.4% were female. In 52.5% of patients, a supine body position at the time of syncope was reported. A history of phobias was reported by 67.6% of patients, and 96.5% of patients also had typical daytime vasovagal syncope. In the 5 studies reporting the results of head-up tilt testing (n = 77), 90.9% of patients had positive tests. Gastrointestinal symptoms were present in the majority of patients with reported rates of 65.6% for upper gastrointestinal symptoms and 86.0% for lower gastrointestinal symptoms.ConclusionPatients with sleep syncope patients are predominantly female with a history of daytime vasovagal syncope. Gastrointestinal symptoms are present in the majority of patients and is therefore an important feature of sleep syncope.
Synthesis and characterization of 3D-zeolite–modified TiO2-based photocatalyst with synergistic effect for elimination of organic pollutant in wastewater treatment
Authors: Liu Na , Qi Ruilin , Sun Xiang , Kawazoe Naoki , Chen Guoping , Yang Yingnan 
Published: October 2022

In this work, zeolite, a porous material with a 3D network structure, was introduced as the carrier to support P/Ag/Ag2O/Ag3PO4/TiO2 (PAgT) composite for synthesizing the 3D-zeolite–modified photocatalyst (Z-PAgT). In this combination, zeolite with strong adsorbability can pre-adsorb and condense organic compounds onto the catalyst surface, thereby helping to speed up the photocatalytic reaction. In the present study, to determine the optimum mass ratio of zeolite to photocatalyst, various samples containing different zeolite additions (0 wt%, 5 wt%, 10 wt%, and 25 wt%) were prepared using the hydrothermal method, respectively. The physical–chemical properties of the as-prepared samples were systematically characterized by different analytical techniques, including XRD, FTIR, SEM, BET, EDX, UV-Vis, and PL. The results revealed that the obtained Z-PAgT-5 sample possessed relatively higher crystallinity, smaller crystalline size, larger specific surface area, narrow band gap, and lower generated electron-hole recombination rate. The photocatalytic degradation of rhodamine B (Rh B) in aqueous suspension has been employed to evaluate the photocatalytic activity of the as-prepared photocatalysts with simulated solar light as an irradiation source. The results showed that Z-PAgT-5 performed the highest photodegradation efficiency, and its degradation rate constant (kapp) (0.188 min−1) is much higher than that of Z-PAgT-0 (0.132 min−1), Z-PAgT-10 (0.050 min−1), Z-PAgT-25 (0.037 min−1), and pure zeolite (0.003 min−1). This super photocatalytic activity of Z-PAgT-5 toward Rh B degradation can be ascribed to the synergistic effect between the 3D-zeolite and PAgT photocatalyst, which made the hybrid zeolite-photocatalyst material possess good adsorption and photodegradation properties. In addition, repetitive experiments demonstrated that the improved Rh B degradation efficiency of Z-PAgT-5 was well maintained even after five recycling runs without any obvious decrease. Hence, the obtained results indicated that Z-PAgT-5 material can be used as a potential photocatalyst for treating organic pollutants during wastewater environmental remediation.
Analysis of RPGR gene mutations in 41 Chinese families affected by X-linked inherited retinal dystrophy
Authors: Liu Xiaozhen , Jia Ruixuan , Meng Xiang , Wang Likun , Yang Liping 
Published: October 2022

Background: This study analyzed the phenotypes and genotypes of 41 Chinese families with inherited retinal dystrophy (IRD) and RPGR gene mutations.Methods: This retrospective analysis evaluated a cohort of 41 patients who were subjected to a specific Hereditary Eye Disease Enrichment Panel (HEDEP) analysis. All (likely) pathogenic variants were determined by Sanger sequencing, and co-segregation analyses were performed on the available family members. All cases were subjected to Sanger sequencing for RPGR open reading frame 15 (ORF15) mutations.Results: A total of 41 probands from different families with a clinical diagnosis of retinitis pigmentosa (RP; 34 cases) and cone-rod dystrophy (CORD; 7 cases) were included in this cohort. According to clinical information, 2, 18, and 21 cases were first assigned as autosomal dominant (AD), sporadic, and X-linked (XL) inheritance, respectively. Several cases of affected females who presented with a male phenotype have been described, posing challenges at diagnosis related to the apparent family history of AD. Mutations were located in RPGR exons or introns 1–14 and in ORF15 of 12 of 41 (29.3%) and 29 of 41 (70.7%) subjects, respectively. Thirty-four (likely) pathogenic mutations were identified. Frameshifts were the most frequently observed variants, followed by nonsense, splice, and missense mutations. Herein, a detailed description of four RP patients carrying RPGR intronic mutations is reported, and in vitro splice assays were performed to confirm the pathogenicity of these intronic mutations.Conclusion: Our findings provide useful insights for the genetic and clinical counseling of patients with XL IRD, which will be useful for ongoing and future gene therapy trials.
The hexosamine biosynthesis pathway-related gene signature correlates with immune infiltration and predicts prognosis of patients with osteosarcoma
Authors: Su Zexin , Wang Chenyang , Pan Runsang , Li Hongbo , Chen Junkai , Tan Jianye , Tian Xiaobin , Lin Tiao , Shen Jingnan 
Published: October 2022

ObjectivesOsteosarcoma is a malignant bone tumor with poor outcomes affecting the adolescents and elderly. In this study, we comprehensively assessed the metabolic characteristics of osteosarcoma patients and constructed a hexosamine biosynthesis pathway (HBP)-based risk score model to predict the prognosis and tumor immune infiltration in patients with osteosarcoma.MethodsGene expression matrices of osteosarcoma were downloaded from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Gene Expression Omnibus (GEO) databases. GSVA and univariate Cox regression analysis were performed to screen the metabolic features associated with prognoses. LASSO regression analysis was conducted to construct the metabolism-related risk model. Differentially expressed genes (DEGs) were identified and enrichment analysis was performed based on the risk model. CIBERSORT and ESTIMATE algorithms were executed to evaluate the characteristics of tumor immune infiltration. Comparative analyses for immune checkpoints were performed and the Tumor Immune Dysfunction and Exclusion (TIDE) algorithm was used to predict immunotherapeutic response. Finally, hub genes with good prognostic value were comprehensive analyzed including drug sensitivity screening and immunohistochemistry (IHC) experiments.ResultsThrough GSVA and survival analysis, the HBP pathway was identified as the significant prognostic related metabolism feature. Five genes in the HBP pathway including GPI, PGM3, UAP1, OGT and MGEA5 were used to construct the HBP-related risk model. Subsequent DEGs and enrichment analyses showed a strong correlation with immunity. Further, CIBERSORT and ESTIMATE algorithms showed differential immune infiltration characteristics correlated with the HBP-related risk model. TIDE algorithms and immune checkpoint analyses suggested poor immunotherapeutic responses with low expression of immune checkpoints in the high-risk group. Further analysis revealed that the UAP1 gene can predict metastasis. IHC experiments suggested that UAP1 expression correlated significantly with the prognosis and metastasis of osteosarcoma patients. When screening for drug sensitivity, high UAP1 expression was suggestive of great sensitivity to antineoplastic drugs including cobimetinib and selumetinib.ConclusionWe constructed an HBP-related gene signature containing five key genes (GPI, PGM3, UAP1, OGT, MGEA5) which showed a remarkable prognostic value for predicting prognosis and can guide immunotherapy and targeted therapy for osteosarcoma.
Hospital safety preparedness during the COVID-19 pandemic: Lessons learned from Vietnam
Authors: Thu Nguyen Thi Hoai , Anh Bui Thi My , Khanh Luong Bao , Anh Pham Tran , Luong Duong Huy 
Published: October 2022

IntroductionThe rapid spread of SARS-CoV-2, the varying vaccine coverage, and the appearance of new variants posed a significant threat during the pandemic, especially in LMIC countries. Hospitals in Vietnam at both central and local levels have had cross-infection of patients and healthcare workers. Therefore, providing a safe and secure environment for staff and patients was a major focus for all healthcare institutions.MethodsWe conducted a cross-sectional study, using both quantitative and qualitative methods, to answer the question of how hospital safety during the COVID-19 pandemic in Vietnamese hospitals was implemented and what the challenges were. Secondary data from a recent national survey of safety in 1,398 hospitals conducted by the Vietnam Ministry of Health (MOH) were extracted and analyzed. In-depth interviews of key health managers and health staff in four selected hospitals were performed to further explore challenges in implementing Decision 3088/QD-BYT.ResultsThe proportion of hospitals classified as “safe hospital”, “safe hospital with moderate level”, and “unsafe hospital” was 91.7%, 7.3%, and 1.0%, respectively. The rate of “safe hospital” was highest in the central level hospitals (96.1%), followed by private hospitals (94.4%), provincial hospitals (94.2%), specialized hospitals (93.1%), regional hospitals (93.0%), and district hospitals (89.9%), while “safe hospital” rates were lowest in the ministerial level hospital group (82.2%). Challenges in ensuring hospital safety in public and private hospitals related to COVID-19 transmission, such as lack of preparedness before COVID-19 and other pandemics, limited hospital facility, limited space and equipment, shortage of human resources, inadequate training and knowledge transfer, poor patient compliance in declaring health conditions, and lack of patient understanding of infection prevention methods, were explored.ConclusionMost hospitals in Vietnam successfully met the classification of “safe hospitals” according to Decision 3088/QD-BYT, a key tool for hospitals to self-assess preparedness and responsiveness to the COVID-19 pandemic. The MOH should adapt the criteria in Decision 3088/QD-BYT to be more suitable for the new phase of the pandemic as we move towards “living with COVID”. Furthermore, we recommend that the MOH work to develop mechanisms or regulations that require hospitals to regularly report on disease preparation and responses for future pandemic preparedness.
Depression in patients with inflammatory bowel disease is associated with increased risk of dementia and Parkinson’s disease: A nationwide, population-based study
Authors: Choi Kookhwan , Lee Hyun Jung , Han Kyungdo , Koh Seong-Joon , Im Jong Pil , Kim Joo Sung 
Published: October 2022

BackgroundInflammatory bowel disease (IBD) may be associated with depression which is considered an important cause of dementia and Parkinson’s disease (PD). In the present study, the effects of depression on the development of dementia and/or PD in patients with IBD were evaluated.Materials and methodsA nationwide population-based cohort study was conducted using claims data from the Health Insurance Review and Assessment Service in Korea. The incidence of dementia and PD were analyzed based on the presence of depression in patients with IBD.ResultsDuring a mean follow-up of 8 years, IBD patients with depression experienced dementia (6.7 vs. 2.0%; p &lt; 0.001) and PD (1.1 vs. 0.3%; p &lt; 0.001) significantly more than IBD patients without depression. Compared with IBD patients without depression, the risk of developing dementia was significantly higher in IBD patients with depression [adjusted hazard ratio (aHR) for IBD, Crohn’s disease (CD), and ulcerative colitis (UC), 2.03, p &lt; 0.001; 1.68, p = 0.033; 2.13, p &lt; 0.001, respectively]. Compared with IBD patients without depression, the risk of developing PD was significantly higher in IBD patients with depression (aHR for IBD, CD, and UC, 2.54, p &lt; 0.001; 1.93, p = 0.470; 2.75, p &lt; 0.001, respectively). The cumulative incidence of dementia and PD in IBD patients with depression was significantly higher than in IBD patients without depression and showed a steady increase after a diagnosis of depression.ConclusionThe risk of dementia and/or PD increased after a diagnosis of depression in patients with IBD.
Upper limb joint coordination preserves hand kinematics after a traumatic brachial plexus injury
Authors: Lustosa Luiggi , Silva Ana Elisa Lemos , Carvalho Raquel de Paula , Vargas Claudia D. 
Published: October 2022

BackgroundTraumatic brachial plexus injury (TBPI) causes a sensorimotor deficit in upper limb (UL) movements.ObjectiveOur aim was to investigate the arm–forearm coordination of both the injured and uninjured UL of TBPI subjects.MethodsTBPI participants (n = 13) and controls (n = 10) matched in age, gender, and anthropometric characteristics were recruited. Kinematics from the shoulder, elbow, wrist, and index finger markers were collected, while upstanding participants transported a cup to their mouth and returned the UL to a starting position. The UL coordination was measured through the relative phase (RP) between arm and forearm phase angles and analyzed as a function of the hand kinematics.ResultsFor all participants, the hand transport had a shorter time to peak velocity (p &lt; 0.01) compared to the return. Also, for the control and the uninjured TBPI UL, the RP showed a coordination pattern that favored forearm movements in the peak velocity of the transport phase (p &lt; 0.001). TBPI participants' injured UL showed a longer movement duration in comparison to controls (p &lt; 0.05), but no differences in peak velocity, time to peak velocity, and trajectory length, indicating preserved hand kinematics. The RP of the injured UL revealed altered coordination in favor of arm movements compared to controls and the uninjured UL (p &lt; 0.001). Finally, TBPI participants' uninjured UL showed altered control of arm and forearm phase angles during the deceleration of hand movements compared to controls (p &lt; 0.05).ConclusionThese results suggest that UL coordination is reorganized after a TBPI so as to preserve hand kinematics.
Ophthalmologic problems correlates with cognitive impairment in patients with Parkinson's disease
Authors: Zhang Chao , Wu Qian-qian , Hou Ying , Wang Qi , Zhang Guang-jian , Zhao Wen-bo , Wang Xu , Wang Hong , Li Wei-guo 
Published: October 2022

ObjectiveVisual impairment is a common non-motor symptom (NMS) in patients with Parkinson's disease (PD) and its implications for cognitive impairment remain controversial. We wished to survey the prevalence of visual impairment in Chinese Parkinson's patients based on the Visual Impairment in Parkinson's Disease Questionnaire (VIPD-Q), identify the pathogens that lead to visual impairment, and develop a predictive model for cognitive impairment risk in Parkinson's based on ophthalmic parameters.MethodsA total of 205 patients with Parkinson's disease and 200 age-matched controls completed the VIPD-Q and underwent neuro-ophthalmologic examinations, including ocular fundus photography and optical coherence tomography. We conducted nomogram analysis and the predictive model was summarized using the multivariate logistic and LASSO regression and verified via bootstrap validation.ResultsOne or more ophthalmologic symptoms were present in 57% of patients with Parkinson's disease, compared with 14% of the controls (χ2-test; p &lt; 0.001). The visual impairment questionnaire showed good sensitivity and specificity (area under the curve [AUC] = 0.918, p &lt; 0.001) and a strong correlation with MoCA scores (Pearson r = −0.4652, p &lt; 0.001). Comparing visual impairment scores between pre- and post-deep brain stimulation groups showed that DBS improved visual function (U-test, p &lt; 0.001). The thickness of the retinal nerve fiber layer and vessel percentage area predicted cognitive impairment in PD.InterpretationThe study findings provide novel mechanistic insights into visual impairment and cognitive decline in Parkinson's disease. The results inform an effective tool for predicting cognitive deterioration in Parkinson's based on ophthalmic parameters.
Changes in intermuscular connectivity during active elbow extension reveal a functional simplification of motor control after stroke
Authors: Delcamp Célia , Cormier Camille , Chalard Alexandre , Amarantini David , Gasq David 
Published: October 2022

BackgroundStroke alters muscle co-activation and notably leads to exaggerated antagonist co-contraction responsible for impaired motor function. However, the mechanisms underlying this exaggerated antagonist co-contraction remain unclear. To fill this gap, the analysis of oscillatory synchronicity in electromyographic signals from synergistic muscles, also called intermuscular coherence, was a relevant tool.ObjectiveThis study compares functional intermuscular connectivity between muscle pairs of the paretic and non-paretic upper limbs of stroke subjects and the dominant limb of control subjects, concomitantly between two muscle pairs with a different functional role, through an intermuscular coherence analysis.MethodsTwenty-four chronic stroke subjects and twenty-four healthy control subjects were included. Subjects performed twenty elbow extensions while kinematic data and electromyographic activity of both flexor and extensor elbow muscles were recorded. Intermuscular coherence was analyzed in the beta frequency band compared to the assessment of antagonist co-contraction.ResultsIntermuscular coherence was higher in the stroke subjects’ paretic limbs compared to control subjects. For stroke subjects, the intermuscular coherence of the antagonist-antagonist muscle pair (biceps brachii—brachioradialis) was higher than that of the agonist-antagonist muscle pair (triceps brachii—brachioradialis). For the paretic limb, intermuscular coherence of the antagonist-antagonist muscle pair presented a negative relationship with antagonist co-contraction.ConclusionDifferences in intermuscular coherence between the paretic limbs of stroke subjects and control subjects suggest a higher common central drive during movement. Furthermore, results highlight the association between stroke-related alteration of intermuscular functional connectivity and the alteration of motor function.
Novel serum proteomic biomarkers for early diagnosis and aggressive grade identification of prostate cancer
Authors: Wang Ce , Liu Guangming , Liu Yehua , Yang Zhanpo , Xin Weiwei , Wang Meng , Li Yang , Yang Lan , Mu Hong , Zhou Chunlei 
Published: October 2022

BackgroundProstate cancer (PCa) is one of the most common tumors and the second leading cause of cancer-related death in men. The discovery of novel biomarkers for PCa diagnosis in the early stage, as well as discriminating aggressive PCa from non-aggressive PCa continue to pose a challenge. The aim of this study was to identify serum proteins that were sensitive and specific enough to detect early-stage and aggressive PCa.MethodsThe serum proteomic profiling of patients with PCa and benign prostatic hyperplasia (BPH) was comprehensively analyzed using data-independent acquisition mass spectrometry (DIA-MS), and the bioinformatics analysis was performed. The differentially expressed proteins (DEPs) of interest were further verified by enzyme-linked immunosorbent assay (ELISA) and immunoturbidimetry assay.ResultsStatistically significant difference in abundance showed 56 DEPs between early-stage PCa and BPH and 47 DEPs between aggressive and non-aggressive PCa patients. In addition, the verification results showed that serum L-selectin concentration was significantly higher (p&lt;0.05) in Gleason 6 PCa when compared with BPH, and the concentration of osteopontin (SPP1) and ceruloplasmin (CP) increased with higher Gleason score.ConclusionsDIA-MS has great potential in cancer-related biomarker screening. Our data demonstrated that adding SPP1 and CP to PSA improved the separation of Gleason 7 (4 + 3) or above from Gleason 7 (3 + 4) or below compared with PSA diagnosis alone. Serum SPP1 and CP could be effective biomarkers to differentiate aggressive PCa (especially Gleason 7 (4 + 3) or above) from non-aggressive disease.