bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on the relationship between nephrotic syndrome and atopic diseases in childhood
Authors: Zheng Yue , He Xuehui , Hou Ling , Wang Xiuli , Zhao Chengguang , Du Yue 
Published: October 2022

ObjectiveThe present study aimed to explore the relationship between nephrotic syndrome and atopic diseases in childhood.MethodsFrom 2018 to 2019, 234 children with first-onset primary nephrotic syndrome (PNS) were selected for observation and long-term follow-up, and the clinical and laboratory data. To compare the levels of total serum IgE, histamine and bradykinin of the same children at the time of first onset, remission and relapse of PNS. The extent of podocyte foot process effacement was compared between the urinary protein negative-conversion group and the proteinuric group with the NS range. The correlation between the urine protein quantification and the extent of foot process effacement was also observed.Results(1) The mean age of 234 children with first-onset PNS was 4.82 ± 3.63 years, with a male to female ratio of 162/72. (2) There were 109 cases (46.58%) with concomitant atopic diseases (AD) and 151 cases (64.53%) with elevated levels of total serum IgE. There were 136 cases with recurrence during the follow-up, of which recurrence due to allergy-related factors was greater than that due to infection-related factors. (3) The total IgE and bradykinin serum levels were significantly higher in children with first-onset PNS and recurrent PNS compared with those in remission, and the differences were statistically significant (P &lt; 0.05). The level of histamine in children with first-onset PNS was higher than that in children with remission (P &lt; 0.05), and there was no significant difference in the level of histamine between children in the recurrence group and those in the remission group (P &gt; 0.05). (4) There was no significant difference in the extent of foot process effacement between the urinary protein negative-conversion group and the proteinuric group with the NS range. There was no significant correlation between the proteinuria quantification and the extent of foot process effacement.ConclusionThere existed a high co-morbidity with AD in children with PNS, and allergy-related factors might be an important recurrence factor in children with PNS. The injury to the filtration barrier in MCD might not only be correlated with podocyte lesions but also with some serum permeability factors. Serum IgE, histamine, and bradykinin might be the plasma permeability factors in children with PNS.
Efficacy and safety of remimazolam besylate in bronchoscopy for adults: A multicenter, randomized, double-blind, positive-controlled clinical study
Authors: Zhou Ying-Yong , Yang Shu-Ting , Duan Kai-Ming , Bai Zhi-Hong , Feng Yun-Fei , Guo Qu-Lian , Cheng Zhi-Gang , Wu Hui , Shangguan Wang-Ning , Wu Xiao-Min , Wang Chun-Hui , Chai Xiao-Qing , Xu Guo-Hai , Liu Cun-Ming , Zhao Gao-Feng , Chen Chun , Gao Bao-An , Li Li-E , Zhang Min , Ouyang Wen , Wang Sai-Ying 
Published: October 2022

Background: With the development of fiberoptic bronchoscopy in the diagnosis and treatment of various pulmonary diseases, the anesthesia/sedation requirements are becoming more demanding, posing great challenges for patient safety while ensuring a smooth examination/surgery process. Remimazolam, a brand-new ultra-short-acting anesthetic, may compensate for the shortcomings of current anesthetic/sedation strategies in bronchoscopy.Methods: This study was a prospective, multicenter, randomized, double-blind, parallel positive controlled phase 3 clinical trial. Subjects were randomized to receive 0.2 mg/kg remimazolam besylate or 2 mg/kg propofol during bronchoscopy to evaluate the efficacy and safety of remimazolam.Results: A total of 154 subjects were successfully sedated in both the remimazolam group and the propofol group, with a success rate of 99.4% (95%CI of the adjusted difference −6.7 × 10%–6% to −5.1 × 10%–6%). The sedative effect of remimazolam was noninferior to that of propofol based on the prespecified noninferiority margin of −5%. Compared with the propofol group, the time of loss of consciousness in the remimazolam group (median 61 vs. 48s, p &lt; 0.001), the time from the end of study drug administration to complete awakening (median 17.60 vs. 12.80 min, p &lt; 0.001), the time from the end of bronchoscopy to complete awakening (median 11.00 vs. 7.00 min, p &lt; 0.001), the time from the end of study drug administration to removal of monitoring (median 19.50 vs. 14.50 min, p &lt; 0.001), and the time from the end of bronchoscopy to removal of monitoring (median 12.70 vs. 8.60 min, p &lt; 0.001) were slightly longer. The incidence of Adverse Events in the remimazolam group and the propofol group (74.8% vs. 77.4%, p = 0.59) was not statistically significant, and none of them had Serious Adverse Events. The incidence of hypotension (13.5% vs. 29.7%, p &lt; 0.001), hypotension requiring treatment (1.9% vs. 7.7%, p = 0.017), and injection pain (0.6% vs. 16.8%, p &lt; 0.001) were significantly lower in the remimazolam group than in the propofol group.Conclusion: Moderate sedation with 0.2 mg/kg remimazolam besylate is effective and safe during bronchoscopy. The incidence of hypotension and injection pain was less than with propofol, but the time to loss of consciousness and recovery were slightly longer.Clinical Trial Registration:clinicaltrials.gov, ChiCTR2000039753
The olfactory receptor OR51E2 activates ERK1/2 through the Golgi-localized Gβγ-PI3Kγ-ARF1 pathway in prostate cancer cells
Authors: Xu Xin , Khater Mostafa , Wu Guangyu 
Published: October 2022

The olfactory receptor OR51E2 is ectopically expressed in prostate tissues and regulates prostate cancer progression, but its function and regulation in oncogenic mitogen-activate protein kinase (MAPK) activation are poorly defined. Here we demonstrate that β-ionone, an OR51E2 agonist, dose-dependently activates extracellular signal-regulated kinases 1 and 2 (ERK1/2) in prostate cancer cells, with an EC50 value of approximate 20 μM and an efficiency comparable to other receptor agonists. We also find that CRISPR-Cas9-mediated knockout of Golgi-translocating Gγ9 subunit, phosphoinositide 3-kinase γ (PI3Kγ) and the small GTPase ADP-ribosylation factor 1 (ARF1), as well as pharmacological inhibition of Gβγ, PI3Kγ and Golgi-localized ARF1, each abolishes ERK1/2 activation by β-ionone. We further show that β-ionone significantly promotes ARF1 translocation to the Golgi and activates ARF1 that can be inhibited by Gγ9 and PI3Kγ depletion. Collectively, our data demonstrate that OR51E2 activates ERK1/2 through the Gβγ-PI3Kγ-ARF1 pathway that occurs spatially at the Golgi, and also provide important insights into MAPK hyper-activation in prostate cancer.
The cumulative effect of chronic stress and depressive symptoms affects heart rate in a working population
Authors: Lutin Erika , Schiweck Carmen , Cornelis Jan , De Raedt Walter , Reif Andreas , Vrieze Elske , Claes Stephan , Van Hoof Chris 
Published: October 2022

BackgroundChronic stress and depressive symptoms have both been linked to increased heart rate (HR) and reduced HR variability. However, up to date, it is not clear whether chronic stress, the mechanisms intrinsic to depression or a combination of both cause these alterations. Subclinical cases may help to answer these questions. In a healthy working population, we aimed to investigate whether the effect of chronic stress on HR circadian rhythm depends on the presence of depressive symptoms and whether chronic stress and depressive symptoms have differential effects on HR reactivity to an acute stressor.Methods1,002 individuals of the SWEET study completed baseline questionnaires, including psychological information, and 5 days of electrocardiogram (ECG) measurements. Complete datasets were available for 516 individuals. In addition, a subset (n = 194) of these participants completed a stress task on a mobile device. Participants were grouped according to their scores for the Depression Anxiety Stress Scale (DASS) and Perceived Stress Scale (PSS). We explored the resulting groups for differences in HR circadian rhythm and stress reactivity using linear mixed effect models. Additionally, we explored the effect of stress and depressive symptoms on night-time HR variability [root mean square of successive differences (RMSSD)].ResultsHigh and extreme stress alone did not alter HR circadian rhythm, apart from a limited increase in basal HR. Yet, if depressive symptoms were present, extreme chronic stress levels did lead to a blunted circadian rhythm and a lower basal HR. Furthermore, blunted stress reactivity was associated with depressive symptoms, but not chronic stress. Night-time RMSSD data was not influenced by chronic stress, depressive symptoms or their interaction.ConclusionThe combination of stress and depressive symptoms, but not chronic stress by itself leads to a blunted HR circadian rhythm. Furthermore, blunted HR reactivity is associated with depressive symptoms and not chronic stress.
Post-traumatic stress disorder among Syrian refugees in Greece
Authors: Theofanidis Dimitrios , Karavasileiadou Savvato , Almegewly Wafa Hamad 
Published: October 2022

BackgroundPost-Traumatic Stress Disorder (PTSD) is a psychiatric entity developed by those who have been through a traumatic experience. The civil wars in Syria and neighboring countries during the past few years might trigger such experiences, and the same could be argued for the difficult journey from the actual war zones to Europe.PurposeTo determine the level of PTSD among Arabic-speaking refugees in a Greek refugee camp, who originate primarily from Syria.MethodsThis study involves (N = 73) Syrian refugees, all located in Greek camp. Data were gathered using the civilian version of PTSD CheckList (PCL-C). The Arabic version of the PCL-C was used. Individual scores were evaluated via use of DSM-IV criteria.ResultsPTSD was found in 58 participants, afflicting both genders (72% of men and 45% of women). In addition, the severity score was recorded to be significantly elevated for the majority of the participants. Finally, the most vulnerable age group was the same for both genders, featuring those between the ages of 35 and 44 years.ConclusionsThe findings of this study demonstrated that the traumatic experiences, suffered by these refugees either before and/or on their journey to Greece, had a severe mental impact. It is imperative that all refugees suffering from this disorder be diagnosed in time and receive appropriate support.
The dyadic care experiences of elderly individuals with disabilities and caregivers in the home setting from the perspective of family resilience: A qualitative study
Authors: Abulaiti Bahaerguli , Zhang Xiangchun , Guan Tingyu , Wang Meng , Jia Shoumei , Wang Anni 
Published: October 2022

BackgroundChina is one of the most rapidly aging countries in Asia, and nearly 90% of elderly individuals with disabilities choose to receive traditional, family-based, long-term care. A majority of family caregivers have insufficient care capacity and experience physical and emotional distress, which in turn affects the elderly.ObjectiveTo describe the dyadic care experiences of elderly individuals with disabilities and their caregivers from the perspective of family resilience.MethodsA phenomenological research method was used. Semi-structured, in-depth, face-to-face interviews with 9 dyads of elderly people with disabilities and their families were conducted from August 2020 to February 2021. The Colaizzi method was used to analyze, summarize, and refine the interview data.ResultsThe dyadic care experiences of elderly individuals with disabilities and their caregivers can be summarized in terms of two themes. Theme 1 is dyadic pressure, which includes the following subthemes: (1) substantial objective burden; (2) dual negative experiences, i.e., the perceived low value of elderly individuals and low positive gains by caregivers; and (3) dyadic emotional transmission. Theme 2 is dyadic cooperative coping, which includes the following subthemes: (1) adjustment of family beliefs, including by giving meaning to stress, maintaining a positive outlook toward the future and ensuring spiritual sustentation; (2) changes in family patterns, including flexible adjustment of family patterns and multichannel utilization of social resources; and (3) improvement of family communication, including effective information transmission, rational emotional expression and emotional connection, and cooperation to solve and prevent problems.ConclusionElderly individuals with disabilities and their family caregivers face multiple physical, psychological, and social difficulties and demands during daily care, in which context negative experiences exert influence on this dyad. They collaborate to exhibit family resilience via the adaptation and improvement of family beliefs, family patterns and family communication. The family as a unit expends a great deal of effort to adapt to conditions of stress in the context of caring and shows family resilience, which is closely related to the family's cultural background and community situation. Dyadic resilience-based interventions can be developed based on core elements found by this study.
Prevalence and correlates of cigarette smoking among Dulong adults in China: A cross-sectional survey in 2020
Authors: Shao Ying , Zha Shun , Qin Mingfang , Zhu Qiuyan , Yang Xiliang , Yang Cangjiang , Wang Xinlin , Zhang Yanli , Yang Weimei , Zhou Kunhua , Li Yanmei , Tang Xian , Yu Qiuli 
Published: October 2022

BackgroundThe Dulong people are one of the minorities in China with the lowest population. In recent years, the lifestyle of the Dulong people has also changed drastically due to income growth and urbanization. This study aims to identify cigarette smoking prevalence and potential risk factors among Dulong adults in China.MethodsThis study was conducted among 1,018 adults based on the Dulong Health Status Investigation and Evaluation (DHSIE) in Gongshan Dulong and Nu Autonomous County of Yunnan province, Southwest China. A cross-sectional design and face-to-face questionnaire were used to collect cigarette smoking habits and demographic information. Data were weighted by post-stratification weights according to the age and gender composition of Dulong resident. We also analyzed univariate and multivariate unconditional logistic regression to explore current smoking correlates.ResultsThe weighted prevalence of ever-smoking, currently smoking, and formerly smoking among Dulong adults is 31.3, 27.7, and 3.6%, respectively. The prevalence of ever-smoking and currently smoking among male participants (57.0 and 50.6%) is much higher than that of female participants (4.0 and 3.4%). Nearly 60% of ever-smokers and current smokers smoked more than 20 cigarettes per day, which are higher than former smokers (35.2%). Among current smokers, 33.1% relapsed, and 28.3% intend to quit smoking. By adjusting for potential confounding variables, multiple logistic regression analysis indicated that male participants (OR = 48.982, 95% CI: 25.026–95.869) and current drinkers (OR = 4.450, 95% CI: 2.556–7.746) are more likely to be current smokers. On the contrary, current smokers are also more likely to be exposed to secondhand smoke (OR = 4.269, 95% CI: 2.330–7.820) and have a higher risk of chronic respiratory disease (OR = 4.955, 95% CI: 1.669–14.706).ConclusionCigarette smoking is highly prevalent among the Dulong people in Southwest China. An appropriate and effective tobacco control strategy is an urgent need for this population.
Sleep quality and creativity in Chinese college student during the COVID-19 pandemic: The mediating role of executive function
Authors: Guo Botang , Song Yue , Zhao Lu , Cheng Xinhui , Ma Hanze , Qiu Xiaohui , Yang Xiuxian , Qiao Zhengxue , Zhao Erying , Bu Tianyi , Yang Jiarun , Mishra Rupam , Yang Yanjie , Zhou Jiawei 
Published: October 2022

BackgroundCOVID-19 has impacted adolescents' interpersonal relationships, life attitudes, and mental health during the past 3 years. However, previous studies predominantly focused on negative problems, while few studies assessed the situation of teenagers from the perspective of positive psychology. Therefore, this study explores the creativity level of Chinese college students during the COVID-19 pandemic, the relationship between sleep quality and creativity, and the mediating role of executive function.MethodA cross-sectional study was conducted across six colleges in Heilongjiang in China, with a sample of 4,258 college students recruited via stratified cluster sampling. Data were collected through an online survey. A mediation model was constructed, and SPSS PROCESS macro was used to analyze the data.ResultsThe creativity score of Chinese college students during the COVID-19 pandemic was 106.48 ± 13.61. Correlation analysis demonstrated that sleep quality correlated negatively with creativity (r = −0.08, P &lt; 0.01) but positively with executive function (r=0.45, P &lt; 0.01), whilst executive function correlated negatively with creativity (r = −0.10, P &lt; 0.01). Moreover, the mediation model revealed that executive function partially mediated the relationship between sleep quality and creativity in college students (indirect effect = −0.017, SE = 0.004, 95% CI = [−0.025, −0.008]). Executive function accounted for 48.6% of the variance in college students' creativity.ConclusionSchool administrators should implement measures such as sleep education to enhance students' sleep quality. Concurrently, curriculum and assessment implementation should enhance executive function. Such measures can contribute to improved student creativity, thus helping students overcome the negative emotional impact of the COVID-19 pandemic.
Non-linear association between composite dietary antioxidant index and depression
Authors: Zhao Leiyong , Sun Yiyan , Cao Renshuang , Wu Xueqiang , Huang Tianjiao , Peng Wei 
Published: October 2022

BackgroundGrowing evidence has shown that the antioxidant diet is a protective factor against depression. However, the relationship between the Composite Dietary Antioxidant Index (CDAI), an important measure of antioxidant diet, and depression has received little attention. Therefore, we investigated the relationship between CDAI and depression through a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018.MethodsThe association between CDAI and depression was investigated using a weighted multiple logistic regression model with subgroup analysis. Non-linear correlations were explored using fitted smoothing curves. And we used a recursive method to figure out the turning point and build a weighted two-piece linear regression model.ResultsIn the multivariate logistic regression model with full adjustment for confounding variables, the ORs (95% CI) for the association between CDAI and depression were 0.83 (0.78, 0.88). Moreover, a non-linear association was found, with 0.16 being the inflection point. Before the inflection point, each unit increase in CDAI was associated with a 30% decrease in the risk of depression. After the inflection point, the risk of depression was found to be reduced by 11% for each unit increase. None of the interactions in all subgroup analyses were statistically significant.ConclusionsOur study highlighted a negative non-linear association between CDAI and depression in a nationally representative sample of US adults. Further clinical and basic research is needed to explore their association better.
Soil microbial population as affected by tillage and rice cultivation modes in Stagnic Anthrosols and Lateritic Red Earth soils in Southern China
Authors: Asenso Evans , Wang Zhimin , Kai Tian , Li Jiuhao , Hu Lian 
Published: October 2022

The microbial population (MP) is considered to be a relatively important part of soil health, quality, and productivity. Therefore, this study aimed to access the effects of tillage and rice cultivation modes on soil MP in Stagnic Anthrosols and Lateritic Red Earth soils. The treatments were as follows: (i) MDS: land tilled twice with a moldboard plow and hill-seeding of pregerminated seeds with a direct seeding machine of four to six seeds per hill at a planting space of 25 × 15 cm, (ii) RDS: land tilled twice with a rotary tiller and hill-seeding of pregerminated seeds with a direct seeding machine of four to six seeds per hill at a planting space of 25 × 15 cm, (iii) MMT: land tilled twice with a moldboard plow and 15-day-old seedlings were mechanically transplanted with a transplanting machine at a transplanting hill of four to six seedlings and at a transplanting space of 25 × 15 cm, and (iv) RMT: land tilled twice with a rotary tiller and 15-day-old seedlings were mechanically transplanted with a transplanting machine at a transplanting hill of four to six seedlings and a transplanting space of 25 × 15 cm. The findings showed that MDS improved the MP and increases rice yield. MDS showed a high increase in MP in both locations and the rice productivity of 32.81% (1H; first harvest) and 13.91% (2H; second harvest) and 16.48% (1H) and 18.13% (2H) for Zeng-Cheng and Yi-Yang, respectively. In conclusion, MDS was found to be better in improving the MP and increasing rice yield and could be adopted as a suitable approach for improving soil health, quality, and productivity.
Case report and literature review: Malignant adenomyoepithelioma after breast augmentation
Authors: Hu Longqing , Qian Bei , Yan Zhecheng , Bing Kaijian , Mei Li , Qu Xincai 
Published: October 2022

BackgroundBreast malignant adenomyoepithelioma (MAME) after breast augmentation has never been reported.Case summaryWe reported a case of a 55-year-old woman who was diagnosed with breast MAME 16 years after breast augmentation. Breast augmentation was performed on the patient with two 200 ml round textured prostheses in the subpectoral plane through axillary incisions in 2004. However, a breast ultrasound in 2020 revealed a suspicious malignant lump in the right breast, which was finally confirmed as MAME by pathology. Skin-sparing modified radical mastectomy and immediate breast reconstruction with expander implantation were performed. Subsequently, the patient received three cycles of chemotherapy with the regimen of anthracycline and cyclophosphamide. In the following nearly 2 years of follow-up, no tumor recurrence and metastasis were found, and the overall treatment was satisfactory for the patient.ConclusionHere, we present a unique case in which a patient was diagnosed with breast MAME after breast augmentation. Skin-sparing modified radical mastectomy and immediate breast reconstruction with expander implantation are feasible approaches that yield at least short-term oncological safety and acceptable aesthetic results. However, whether there is a potential relationship between MAME and breast implants remains to be further explored. Meanwhile, due to the rarity of breast MAME, more authoritative strategies considering both oncological safety and aesthetics to seek better long-term therapeutic effects are needed.