bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary congestion during Exercise stress Echocardiography in Hypertrophic Cardiomyopathy
Authors: Pálinkás Eszter Dalma , Re Federica , Peteiro Jesus , Tesic Milorad , Pálinkás Attila , Torres Marco Antonio Rodrigues , Dikic Ana Djordjevic , Beleslin Branko , Van De Heyning Caroline M. , D’Alfonso Maria Grazia , Mori Fabio , Ciampi Quirino , de Castro Silva Pretto José Luis , Simova Iana , Nagy Viktória , Boda Krisztina , Sepp Róbert , Olivotto Iacopo , Pellikka Patricia A. , Picano Eugenio 
Published: November 2022

Abstract
Background
B-lines detected by lung ultrasound (LUS) during exercise stress echocardiography (ESE), indicating pulmonary congestion, have not been systematically evaluated in patients with hypertrophic cardiomyopathy (HCM).

Aim
To assess the clinical, anatomical and functional correlates of pulmonary congestion elicited by exercise in HCM.

Methods
We enrolled 128 HCM patients (age 52 ± 15 years, 72 males) consecutively referred for ESE (treadmill in 46, bicycle in 82 patients) in 10 quality-controlled centers from 7 countries (Belgium, Brazil, Bulgaria, Hungary, Italy, Serbia, Spain). ESE assessment at rest and peak stress included: mitral regurgitation (MR, score from 0 to 3); E/e’; systolic pulmonary arterial pressure (SPAP) and end-diastolic volume (EDV). Change from rest to stress was calculated for each variable. Reduced preload reserve was defined by a decrease in EDV during exercise. B-lines at rest and at peak exercise were assessed by lung ultrasound with the 4-site simplified scan. B-lines positivity was considered if the sum of detected B-lines was ≥ 2.

Results
LUS was feasible in all subjects. B-lines were present in 13 patients at rest and in 38 during stress (10 vs 30%, p < 0.0001). When compared to patients without stress B-lines (n = 90), patients with B-lines (n = 38) had higher resting E/e’ (14 ± 6 vs. 11 ± 4, p = 0.016) and SPAP (33 ± 10 vs. 27 ± 7 mm Hg p = 0.002). At peak exercise, patients with B-lines had higher peak E/e’ (17 ± 6 vs. 13 ± 5 p = 0.003) and stress SPAP (55 ± 18 vs. 40 ± 12 mm Hg p < 0.0001), reduced preload reserve (68 vs. 30%, p = 0.001) and an increase in MR (42 vs. 17%, p = 0.013) compared to patients without congestion. Among baseline parameters, the number of B-lines and SPAP were the only independent predictors of exercise pulmonary congestion.

Conclusions
Two-thirds of HCM patients who develop pulmonary congestion on exercise had no evidence of B-lines at rest. Diastolic impairment and mitral regurgitation were key determinants of pulmonary congestion during ESE. These findings underscore the importance of evaluating hemodynamic stability by physiological stress in HCM, particularly in the presence of unexplained symptoms and functional limitation.
Health risk assessment of heavy metal concentration in muscle of Chelon auratus and Chelon saliens from the southern Caspian Sea
Authors: Bakhshalizadeh Shima , Liyafoyi Adeleh Rostamzadeh , Fazio Francesco , Mora-Medina Rafael , Ayala-Soldado Nahúm 
Published: November 2022

AbstractHeavy metals are one of the most serious pollutants in aquatic ecosystems, and their accumulation in fish products causes harmful effects on human health. In this context, we set out to determine the concentrations of heavy metals in the muscle of two fish species of commercial interest, Chelon auratus and Chelon saliens on the south coast of the Caspian Sea. We aimed to assess the degree of environment contamination in this area and to estimate the potential risk to human health derived from the consumption of fish. The mean concentrations of the different metals analysed were very varied in both species. In fact, some concentrations exceeded the permissible limits for the protection of human health for Cd and Pb, and some values of As were above those referenced by other authors in same species in the Caspian Sea. None of the estimated daily intake values exceeded the tolerable intake based on the consumption under consideration. Nonetheless, the accumulative hazard values evidenced a potential risk to human health, Pb and Hg being those giving a higher target hazard quotient. The cancer risk from exposure to As from fish consumption in children was above the “acceptable” risk to life. Thus, in view of the accumulative nature of heavy metals, a moderate and non-abusive fish consumption in this area, particularly in children, would be recommendable.
Corporate Counterspeech
Authors: Ancell Aaron 
Published: November 2022

AbstractAre corporations ever morally obligated to engage in counterspeech—that is, in speech that aims to counter hate speech and misinformation? While existing arguments in moral and political philosophy show that individuals and states have such obligations, it is an open question whether those arguments apply to corporations as well. In this essay, I show how two such arguments—one based on avoiding complicity, and one based on duties of rescue—can plausibly be extended to corporations. I also respond to several objections to corporate counterspeech.
Online scheduling using a fixed template: the case of outpatient chemotherapy drug administration
Authors: Hesaraki Alireza F. , Dellaert Nico P. , de Kok Ton 
Published: November 2022

AbstractIn this paper, we use a fixed template of slots for the online scheduling of appointments. The template is a link between planning the service capacity at a tactical level and online scheduling at an operational level. We develop a detailed heuristic for the case of drug administration appointments in outpatient chemotherapy. However, the approach can be applied to online scheduling in other application areas as well. The desired scheduling principles are incorporated into the cost coefficients of the objective function of a binary integer program for booking appointments in the template, as requests arrive. The day and time of appointments are decided simultaneously, rather than sequentially, where optimal solutions may be eliminated from the search. The service that we consider in this paper is an example to show the versatility of a fixed template online scheduling model. It requires two types of resource, one of which is exclusively assigned for the whole appointment duration, and the other is shared among multiple appointments after setting up the service. There is high heterogeneity among appointments on a day of this service. The appointments may range from fifteen minutes to more than eight hours. A fixed template gives a pattern for the scheduling of possibly required steps before the service. Instead of maximizing the fill-rate of the template, the objective of our heuristic is to have high performance in multiple indicators pertaining to various stakeholders (patients, nurses, and the clinic). By simulation, we illustrate the performance of the fixed template model for the key indicators.
Community-based Agency Delivery of Parent-Child Interaction Therapy: Comparing Outcomes for Children with and Without Autism Spectrum Disorder and/or Developmental Delays
Authors: Quetsch Lauren B. , Bradley Rebecca S , Theodorou Laurie , Newton Kathleen , McNeil Cheryl B. 
Published: November 2022

AbstractWhile externalizing behaviors are common among children with autism spectrum disorder (ASD), there is a shortage of specialist community-based clinicians to provide treatment. Parent–Child Interaction Therapy (PCIT), an intervention designed to reduce child disruptive behaviors, may be effective for families of children with ASD but has rarely been studied outside of university-based research settings. We examined the effectiveness of PCIT delivered for children with (N = 109) and without (N = 2,324) ASD/developmental delays (DD) across community-based agencies in Oregon. Findings revealed significant reductions in disruptive behavior and positive changes in the parent-child relationship in both groups. These findings support PCIT as an efficacious intervention for children with ASD/DD and demonstrate PCIT’s promise in community-based agencies with non-specialized clinicians.
“It is more Important than food sometimes”; Meanings and Functions of Music in the Lives of Autistic Adults Through a hermeneutic-phenomenological Lense
Authors: Korošec Kaja , Osika Walter , Bojner-Horwitz Eva 
Published: November 2022

AbstractSubjective experiences of autistic adults remain under-researched, especially in the field of art. To learn more about their uses and functions of music, we interviewed 13 autistic adults and through a hermeneutic-phenomenological analysis found four overarching themes: Well-being, Identity and self-development, Connectedness, and Negative experiences. Findings show a broad and deep meaning of music in their lives, spanning from seemingly trivial functions such as making chores more enjoyable, to existential questions, such as choosing to stay alive. We discuss the often-overlooked negative effects or experiences of music, noting that positive and negative effects must always be addressed together if we are to use music to lower stress and support well-being.
IRAK1 Duplication in MECP2 Duplication Syndrome Does Not Increase Canonical NF-κB–Induced Inflammation
Authors: Gottschalk Ilona , Kölsch Uwe , Wagner Dimitrios L. , Kath Jonas , Martini Stefania , Krüger Renate , Puel Anne , Casanova Jean-Laurent , Jezela-Stanek Aleksandra , Rossi Rainer , Chehadeh Salima El , Van Esch Hilde , von Bernuth Horst 
Published: November 2022

Abstract
Purpose
Besides their developmental and neurological phenotype, most patients with MECP2/IRAK1 duplication syndrome present with recurrent and severe infections, accompanied by strong inflammation. Respiratory infections are the most common cause of death. Standardized pneumological diagnostics, targeted anti-infectious treatment, and knowledge of the underlying pathomechanism that triggers strong inflammation are unmet clinical needs. We investigated the influence of IRAK1 overexpression on the canonical NF-κB signaling as a possible cause for excessive inflammation in these patients.

Methods
NF-κB signaling was examined by measuring the production of proinflammatory cytokines and evaluating the IRAK1 phosphorylation and degradation as well as the IκBα degradation upon stimulation with IL-1β and TLR agonists in SV40-immortalized fibroblasts, PBMCs, and whole blood of 9 patients with MECP2/IRAK1 duplication syndrome, respectively.

Results
Both, MECP2/IRAK1-duplicated patients and healthy controls, showed similar production of IL-6 and IL-8 upon activation with IL-1β and TLR2/6 agonists in immortalized fibroblasts. In PBMCs and whole blood, both patients and controls had a similar response of cytokine production after stimulation with IL-1β and TLR4/2/6 agonists. Patients and controls had equivalent patterns of IRAK1 phosphorylation and degradation as well as IκBα degradation upon stimulation with IL-1β.

Conclusion
Patients with MECP2/IRAK1 duplication syndrome do not show increased canonical NF-κB signaling in immortalized fibroblasts, PBMCs, and whole blood. Therefore, we assume that these patients do not benefit from a therapeutic suppression of this pathway.
The Role of Attachment in Gambling Behaviors and Gambling Disorder: A Systematic Review
Authors: Ghinassi Simon , Casale Silvia 
Published: November 2022

AbstractIn recent years, a growing number of attachment-based studies have contributed to the understanding of both substance and behavioral addictions. Although gambling is a form of addictive behavior widespread all over the world, both among young people and adults, the evidence on the association between attachment-related phenomena and gambling has not yet been systematized in literature. The aim of the present study, therefore, is to provide a systematic literature review aimed at summarizing the empirical evidence on this topic. Following the updated 2020 PRISMA guidelines, a systematic search in four electronic scientific databases (Scopus, PubMed, PsycInfo and Web of Science) was conducted. After removing duplicates, 146 records were double-screened, with 12 articles meeting the inclusion criteria. Additionally, by means of a backward search a further article was selected. Altogether, 13 articles were selected for the present systematic review. With few exceptions, the results underline the significant role played by attachment-related phenomena in gambling behaviors, highlighting that specific attachment contexts have a different influence on gambling, also depending on whether gamblers are youths or adults. In particular, while secure attachment has proven to be a protective factor for the onset of gambling behavior, insecure attachment has emerged to be a vulnerability factor in two ways. On the one hand, it directly favors gambling behaviors; on the other, it affects coping strategies and the individual’s ability to identify and regulate emotions, which in turn predict gambling. Limitations, strengths, and implications of the present systematic review are discussed.
Valuing Depression Using the Well-Being Valuation Approach
Authors: Andrén Daniela 
Published: November 2022

AbstractThe continuously dramatic rise of the number of people suffering from depression is attracting an increasing demand for effective ways of preventing depression. Besides the need for new interventions, there is also a continuous call for a more robust framework for economic evaluation of public interventions. Taking into account people’s preferences for public goods is not straightforward to quantify, and therefore, in addition to designing a new technique for valuing nonmarket goods and services, it is equally important to use valuation methods that are not yet established as traditional. One less commonly used method to assess the cost of depression in monetary terms is the well-being valuation method or the life satisfaction approach, which requires answers to only a few questions that are significantly less time demanding for the respondents than more traditional approaches. We added a well-being question to a contingent valuation web-survey that describes hypothetical interventions aimed to prevent depression in Sweden and estimated that the loss in life satisfaction for individuals who experienced depression varies between approximately 350 and 45,000 euros per year. The monetary compensation would be, on average, higher for individuals who experienced own depression than for those who know someone near, family or friend, who experienced depression, for men than for women, and for middle-aged than for younger and older individuals, respectively.
Piecewise-Tunneled Captive Processes and Corridored Random Particle Systems
Authors: Mengütürk Levent Ali , Mengütürk Murat Cahit 
Published: November 2022

AbstractWe introduce a family of processes that generalises captive diffusions, whereby the stochastic evolution that remains within a pair of time-dependent boundaries can further be piecewise-tunneled internally. The tunneling effect on the dynamics can be random such that the process has non-zero probability to find itself within any possible tunnel at any given time. We study some properties of these processes and apply them in modelling corridored random particles that can be observed in fluid dynamics and channeled systems. We construct and simulate mean-reverting piecewise-tunneled captive models for demonstration. We also propose a doubly-stochastic system in which the tunnels themselves are generated randomly by another stochastic process that jumps at random times.
Fast neutron induced gamma rays from (n,n’), (n,p) and (n,α) reactions on CaCO3
Authors: Ophoven Niklas , Ilic Zeljko , Mauerhofer Eric , Randriamalala Tsitohaina H. , Vezhlev Egor , Stieghorst Christian , Révay Zsolt , Brückel Thomas , Jolie Jan , Strub Erik 
Published: November 2022

AbstractEmission of prompt gamma rays following (n,n’), (n,p) and (n,α) reactions induced by irradiation of a calcium carbonate (CaCO3) sample with a beam of fission neutrons was investigated with a modified version of the FaNGaS (Fast Neutron-induced Gamma-ray Spectrometry) instrument operated at the Heinz Maier-Leibnitz Zentrum (MLZ) in Garching. The neutron spectrum has an average energy of 2.30 MeV and at sample position the fast neutron flux was (1.13 ± 0.04) × 108 cm−2 s−1. The measurement was performed at an angle of 90° between neutron beam and detector. In total, we claim the identification of 38 prompt gamma lines, from which we have assigned 12 to the (n,n’) reaction in calcium (7 for 40Ca, 1 for 42Ca and 4 for 44Ca), 1 to the 12C(n,n’)12C reaction, and 2 to the (n,n’) reaction in oxygen (1 for 16O and 1 for 18O). The other observed gamma lines are attributed to the 40Ca(n,p)40K reaction (20 lines) and to the 40Ca(n,α)37Ar reaction (3 lines). Relative intensities and fast neutron spectrum averaged partial cross sections of the gamma lines are presented and compared with available literature data. Our results were found to be in good agreement with available literature data but also improved and complemented it, as we have pointed out possible errors and identified new lines. Additionally, for a counting time of 12 h the detection limits of calcium, carbon and oxygen were determined as 5, 13 and 64 mg, respectively.
3DVerifier: efficient robustness verification for 3D point cloud models
Authors: Mu Ronghui , Ruan Wenjie , Marcolino Leandro S. , Ni Qiang 
Published: November 2022

Abstract3D point cloud models are widely applied in safety-critical scenes, which delivers an urgent need to obtain more solid proofs to verify the robustness of models. Existing verification method for point cloud model is time-expensive and computationally unattainable on large networks. Additionally, they cannot handle the complete PointNet model with joint alignment network that contains multiplication layers, which effectively boosts the performance of 3D models. This motivates us to design a more efficient and general framework to verify various architectures of point cloud models. The key challenges in verifying the large-scale complete PointNet models are addressed as dealing with the cross-non-linearity operations in the multiplication layers and the high computational complexity of high-dimensional point cloud inputs and added layers. Thus, we propose an efficient verification framework, 3DVerifier, to tackle both challenges by adopting a linear relaxation function to bound the multiplication layer and combining forward and backward propagation to compute the certified bounds of the outputs of the point cloud models. Our comprehensive experiments demonstrate that 3DVerifier outperforms existing verification algorithms for 3D models in terms of both efficiency and accuracy. Notably, our approach achieves an orders-of-magnitude improvement in verification efficiency for the large network, and the obtained certified bounds are also significantly tighter than the state-of-the-art verifiers. We release our tool 3DVerifier via https://github.com/TrustAI/3DVerifier for use by the community.
Deontic Modality in the GDPR Based Finnish Privacy Notices in the Light of the Transparency Principle
Authors: Rydzewska-Siemiątkowska Joanna 
Published: November 2022

AbstractSince its inception the General Data Protection Regulation has introduced a number of rights and obligations that relate to the personal data processing. As the Regulation requires that all information about data subjects’ rights be conveyed in a clear and plain language (transparency principle), this study focuses on the linguistic means of expressing rights and obligations in the GDPR based privacy notices. The article aims at scrutinising the features and context of deontic expressions which may influence the clear message. The research corpus consists of fourteen privacy notices of Finnish design companies which were analysed in order to identify deontic expressions. They were juxtaposed with the GDPR text and some discrepancies were found in their frequency and modal patterns. The qualitative analysis of the expressions with the help of Easy Language Meter criteria for Finnish revealed that privacy notices show simplifying tendencies like choice of modal expressions, the use of certain subjects and the way of addressing the reader. These comply with the Plain Language principles and thus the transparency principle highlighted in the GDPR.
Hereditarily Structurally Complete Intermediate Logics: Citkin’s Theorem Via Duality
Authors: Bezhanishvili Nick , Moraschini Tommaso 
Published: November 2022

AbstractA deductive system is said to be structurally complete if its admissible rules are derivable. In addition, it is called hereditarily structurally complete if all its extensions are structurally complete. Citkin (1978) proved that an intermediate logic is hereditarily structurally complete if and only if the variety of Heyting algebras associated with it omits five finite algebras. Despite its importance in the theory of admissible rules, a direct proof of Citkin’s theorem is not widely accessible. In this paper we offer a self-contained proof of Citkin’s theorem, based on Esakia duality and the method of subframe formulas. As a corollary, we obtain a short proof of Citkin’s 2019 characterization of hereditarily structurally complete positive logics.
Manganese Based Perovskites in Soot Oxidation: Far from Noble Metals?
Authors: Brusamarello Elena , Peron Giacomo , Nigrelli Filippo , Glisenti Antonella 
Published: November 2022

AbstractMn-based catalysts for soot oxidation have been developed without noble metals. The compositions are LaMn0.9Co0.1O3, La0.9K0.1Mn0.9Co0.1O3 (LKMC), Sr0.9K0.1Mn0.9Co0.1O3 and 0.1 K/La0.9Mn0.9Co0.1O3: Mn provides stability to the structure both in oxidizing and reducing atmospheres and efficiently exchanges oxygen. Moreover, Co doping enhances soot oxidation. Adding La or Sr as A-site cation in the perovskite composition allows comparing the behaviors of the so-obtained perovskites, and K doping was chosen to increase catalytic activity both in soot and NOx removal. After the wet synthesis, the catalysts were tested for soot oxidation in presence of oxygen and nitrogen monoxide in overstoichiometric oxygen content. Temperature Programmed Oxidation tests were performed and double doping increases the oxidative catalytic activity: LKMC shows the lowest soot conversion temperature (306 °C, soot in tight contact with the catalyst). Sr doping results in worse performances, due to the formation of SrCO3. K incorporation helps oxygen vacancies formation, beneficial to the catalytic activity, through the Mars-van Krevelen mechanism.