bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monojet signatures from gluino and squark decays
Authors: Lara Iñaki , Buanes Trygve , Masełek Rafał , Nojiri Mihoko M. , Rolbiecki Krzysztof , Sakurai Kazuki 
Published: October 2022

Abstract
We study the monojet and dijet channels at the LHC as a tool for searching for squarks and gluinos. We consider two separate R-parity conserving supersymmetric scenarios. In the first scenario we postulate a large mass hierarchy between squarks ($$ \overset{\sim }{q} $$

q
~

) and winos ($$ \overset{\sim }{W} $$

W
~

), and wino-like neutralino is assumed to be the lightest supersymmetric particle (LSP). The associated squark-wino production, pp →$$ \overset{\sim }{q}\overset{\sim }{W} $$

q
~

W
~

, then leads to a monojet-like signature, where the high pT jet is originated from the squark decay, $$ \overset{\sim }{q} $$

q
~

→ q + $$ \overset{\sim }{W} $$

W
~

. We demonstrate that this associated production, as well as the pp →$$ \overset{\sim }{W}\overset{\sim }{W} $$

W
~

W
~

+ jets production, have a significant impact on the exclusion limit in the squark-neutralino mass plane. The second scenario postulates that the lighter of the squark and gluino is only a few GeV heavier than the LSP neutralino. The associated squark-gluino production, pp →$$ \overset{\sim }{q}\overset{\sim }{g} $$

q
~

g
~

, then leads to a distinctive monojet signature, where the high pT jet is produced from the decay of the heavier coloured particle into the lighter one ($$ \overset{\sim }{q} $$

q
~

→ q+$$ \overset{\sim }{g} $$

g
~

for $$ {m}_{\tilde{q}} $$

m

q
~

>$$ {m}_{\tilde{g}} $$

m

g
~

and $$ \overset{\sim }{g} $$

g
~

→ q+$$ \overset{\sim }{q} $$

q
~

for $$ {m}_{\tilde{g}} $$

m

g
~

>$$ {m}_{\tilde{q}} $$

m

q
~

). The lighter coloured particle is effectively regarded as an invisible particle since the decay products are soft due to the approximate mass degeneracy. We recast existing monojet and dijet analyses and find a non-trivial exclusion limit in the squark-gluino mass plane in this scenario.
Non-relativistic and ultra-relativistic scaling limits of multimetric gravity
Authors: Ekiz Ertuğrul , Kasikci Oguzhan , Ozkan Mehmet , Senisik Cemal Berfu , Zorba Utku 
Published: October 2022

Abstract
We present a method of contraction that can be applied to re-construct the recent extended non-relativistic and ultra-relativistic algebras as well as corresponding action principles. The methodology involves the use of multiple copies of Poincaré algebra. Consequently, the contraction defines non-relativistic or ultra-relativistic limits of multimetric theories of gravity. In particular, we show that the non-relativistic scaling limit of bi-metric gravity corresponds to the recent formulation of an action principle for Newtonian gravity with a constant background mass density.
Lost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism
Authors: Wohlfarter Yvonne , Eidelpes Reiner , Yu Ryan D. , Sailer Sabrina , Koch Jakob , Karall Daniela , Scholl-Bürgi Sabine , Amberger Albert , Hillen Hauke S. , Zschocke Johannes , Keller Markus A. 
Published: October 2022

AbstractMultifunctional proteins are challenging as it can be difficult to confirm pathomechanisms associated with disease-causing genetic variants. The human 17β-hydroxysteroid dehydrogenase 10 (HSD10) is a moonlighting enzyme with at least two structurally and catalytically unrelated functions. HSD10 disease was originally described as a disorder of isoleucine metabolism, but the clinical manifestations were subsequently shown to be linked to impaired mtDNA transcript processing due to deficient function of HSD10 in the mtRNase P complex. A surprisingly large number of other, mostly enzymatic and potentially clinically relevant functions have been attributed to HSD10. Recently, HSD10 was reported to exhibit phospholipase C-like activity towards cardiolipins (CL), important mitochondrial phospholipids. To assess the physiological role of the proposed CL-cleaving function, we studied CL architectures in living cells and patient fibroblasts in different genetic backgrounds and lipid environments using our well-established LC–MS/MS cardiolipidomic pipeline. These experiments revealed no measurable effect on CLs, indicating that HSD10 does not have a physiologically relevant function towards CL metabolism. Evolutionary constraints could explain the broad range of reported substrates for HSD10 in vitro. The combination of an essential structural with a non-essential enzymatic function in the same protein could direct the evolutionary trajectory towards improvement of the former, thereby increasing the flexibility of the binding pocket, which is consistent with the results presented here.
Proteome alterations during clonal isolation of established human pancreatic cancer cell lines
Authors: Bernhard P. , Feilen T. , Rogg M. , Fröhlich K. , Cosenza-Contreras M. , Hause F. , Schell C. , Schilling O. 
Published: October 2022

AbstractClonal isolation is an integral step of numerous workflows in genome editing and cell engineering. It comprises the isolation of a single progenitor cell from a defined cell line population with subsequent expansion to obtain a monoclonal cell population. This process is associated with transient loss of cell–cell contacts and absence of a multicellular microenvironment. Previous studies have revealed transcriptomic changes upon clonal isolation with cell line specific extent. Since transcriptome alterations are only partially reflected on the proteome level, we sought to investigate the impact of clonal isolation on the cellular proteome to a depth of > 6000 proteins in three established pancreatic cancer cell lines. We show that clonal isolation does have an impact on the cellular proteome, however, with cell line specific extent, affecting different biological processes, and also depending on the isolation method. We demonstrate a different impact of clonal isolation on mesenchymal- and epithelial-derived cell lines mainly affecting cell proliferation, metabolism, cell adhesion and cellular stress. The results bear relevance to the field of genomic editing and cell engineering and highlight the need to consider the impact of clonal isolation when interpreting data stemming from experiments that include this step.
Wood modification with phenol urea formaldehyde (PUF) resin: the influence of wood species selection on the dimensional stability
Authors: Kupfernagel Carlo , Spear Morwenna J. , Pitman Andrew J. , Ormondroyd Graham A. 
Published: October 2022

AbstractWood modification is an excellent way to improve material properties, prolong service life, and pave the way for new applications for timber in the built environment. The aim of this study is to establish the influence of wood species in the modification process with phenol urea formaldehyde resin. Seven hardwoods and four softwoods were compared in an identical treatment. Since the wood species is the main variable, the study provides a clear insight as to its influence on modification—something not previously investigated. Small wood blocks of all eleven species were impregnated with low-molecular weight phenol urea formaldehyde resin and were subsequently heat-cured at 150 °C. Mass and dimensions of specimens were carefully monitored throughout three cycles of oven-drying and water-soaking to determine anti-swelling efficiency, bulking coefficient, and swelling coefficient. The results showed a clear relationship between density, bulking-, and swelling coefficients. Beyond this well-known relationship it was observed that species with similar density (e.g., lime and sycamore) had significantly different bulking coefficients and anti-swelling efficiencies. Reasons for these differences, which are independent of density, are discussed. The soaking solution was analysed to determine the nature of leached substances showing a correlation between the amount of leachate and the UV-absorbance (272 nm) of the solution.
WWOX and metabolic regulation in normal and pathological conditions
Authors: Baryła Izabela , Kośla Katarzyna , Bednarek Andrzej K. 
Published: October 2022

AbstractWW domain-containing oxidoreductase (WWOX) spans the common fragile site FRA16D. There is evidence that translocations and deletions affecting WWOX accompanied by loss of expression are frequent in many cancers and often correlate with a worse prognosis. Additionally, WWOX germline mutations were also found to be the cause of pathologies of brain development. Because WWOX binds to some transcription factors, it is a modulator of many cellular processes, including metabolic processes. Recently, studies have linked WWOX to familial dyslipidemias, osteopenia, metabolic syndrome, and gestational diabetes, confirming its role as a regulator of steroid, cholesterol, glucose, and normal bone metabolism. The WW domain of WWOX is directly engaged in the control of the activity of transcription factors such as HIF1α and RUNX2; therefore, WWOX gene alterations are associated with some metabolic abnormalities. Presently, most interest is devoted to the associations between WWOX and glucose and basic energy metabolism disturbances. In particular, its involvement in the initiation of the Warburg effect in cancer or gestational diabetes and type II diabetes is of interest. This review is aimed at systematically and comprehensively presenting the current state of knowledge about the participation of WWOX in the metabolism of healthy and diseased organisms.
Geometrical investigation of cooling channels with two alternated isothermal blocks under forced convective turbulent flow
Authors: Feijó Bruno Costa , Fragassa Cristiano , Teixeira Filipe Branco , Rocha Luiz Alberto Oliveira , Isoldi Liércio André , dos Santos Elizaldo Domingues 
Published: October 2022

AbstractThe present work performs a numerical analysis of the geometrical investigation of a two-dimensional channel with two alternated isothermal rectangular blocks subjected to turbulent forced convective flows. Constructal Design associated with Exhaustive Search is used to investigate the influence of the geometry of the isothermal blocks over the performance of the cooling convective flows in a multi-objective viewpoint, i.e., considering the pressure drop and heat transfer rate. The time-averaged equations of continuity, momentum, and energy conservation are solved with the finite volume method. The k–$$\omega $$
ω
shear stress transport model is used for the closure of turbulence. The effect of the two proposed degrees of freedom, the height/length ratio of the two blocks ($$H_{1}/L_{1}$$

H
1

/

L
1

and $$H_{2}/L_{2})$$

H
2

/

L
2

)

, is analyzed in relation to the proposed objectives. Regarding the thermal purpose, the geometry with the highest insertion into the channel led to the best performance, while the opposite configuration led to the best fluid dynamic performance. This behavior was similar to that previously found in the literature for forced convective laminar flows. For a multi-objective perspective, the use of technique for order preference by similarity to ideal solution indicated that asymmetric blocks led to the best multi-objective performance when both performance indicators had the same weight.
The progression of doxorubicin-induced intestinal mucositis in rats
Authors: Kullenberg F. , Peters K. , Luna-Marco C. , Salomonsson A. , Kopsida M. , Degerstedt O. , Sjöblom M. , Hellström P. M. , Heindryckx F. , Dahlgren D. , Lennernäs H. 
Published: October 2022

AbstractChemotherapy-induced intestinal mucositis is a severe side effect contributing to reduced quality of life and premature death in cancer patients. Despite a high incidence, a thorough mechanistic understanding of its pathophysiology and effective supportive therapies are lacking. The main objective of this rat study was to determine how 10 mg/kg doxorubicin, a common chemotherapeutic, affected jejunal function and morphology over time (6, 24, 72, or 168 h). The secondary objective was to determine if the type of dosing administration (intraperitoneal or intravenous) affected the severity of mucositis or plasma exposure of the doxorubicin. Morphology, proliferation and apoptosis, and jejunal permeability of mannitol were examined using histology, immunohistochemistry, and single-pass intestinal perfusion, respectively. Villus height was reduced by 40% after 72 h, preceded at 24 h by a 75% decrease in proliferation and a sixfold increase in apoptosis. Villus height recovered completely after 168 h. Mucosal permeability of mannitol decreased after 6, 24, and 168 h. There were no differences in intestinal injury or plasma exposure after intraperitoneal or intravenous doxorubicin dosing. This study provides an insight into the progression of chemotherapy-induced intestinal mucositis and associated cellular mucosal processes. Knowledge from this in vivo rat model can facilitate development of preventive and supportive therapies for cancer patients.
Do graspable objects always leave a motor signature? A study on memory traces
Authors: Daprati Elena , Balestrucci Priscilla , Nico Daniele 
Published: October 2022

AbstractSeveral studies have reported the existence of reciprocal interactions between the type of motor activity physically performed on objects and the conceptual knowledge that is retained of them. Whethercovertmotor activity plays a similar effect is less clear. Certainly, objects are strong triggers for actions, and motor components can make the associated concepts more memorable. However, addition of an action-related memory trace may not always be automatic and could rather depend on ‘how’ objects are encountered. To test this hypothesis, we compared memory for objects that passive observers experienced as verbal labels (the word describing them), visual images (color photographs) and actions (pantomimes of object use). We predicted that the more direct the involvement of action-related representations the more effective would be the addition of a motor code to the experience and the more accurate would be the recall. Results showed that memory for objects presented as words i.e., a format that might only indirectly prime the sensorimotor system, was generally less accurate compared to memory for objects presented as photographs or pantomimes, which are more likely to directly elicit motor simulation processes. In addition, free recall of objects experienced as pantomimes was more accurate when these items afforded actions performed towards one’s body than actions directed away from the body. We propose that covert motor activity can contribute to objects’ memory, but the beneficial addition of a motor code to the experience is not necessarily automatic. An advantage is more likely to emerge when the observer is induced to take a first-person stance during the encoding phase, as may happen for objects affording actions directed towards the body, which obviously carry more relevance for the actor.
Fetal 4D flow MRI of the great thoracic vessels at 3 Tesla using Doppler-ultrasound gating: a feasibility study
Authors: Knapp J. , Tavares de Sousa M. , Lenz A. , Herrmann J. , Zhang S. , Kording F. , Hergert B. , Adam G. , Bannas P. , Schoennagel B. P. 
Published: October 2022

Abstract
Objectives
To evaluate the feasibility of Doppler-ultrasound (DUS)-gated 4D flow MRI of the fetal great thoracic vessels at 3T in a clinical setting.

Methods
Sixteen consecutive fetuses (range 30+4–38+5 weeks) with (n = 11) and without (n = 5) cardiovascular anomalies underwent 4D flow MRI of the great thoracic vessels at 3T. Direct fetal cardiac gating was obtained using a MR-compatible DUS device. 4D flow MRI–based visualisation and quantification of four target regions (ascending aorta (AAo), descending aorta (DAo), main pulmonary artery (MPA), and ductus arteriosus (DA)) were performed using dedicated software.

Results
Fetal 4D flow MRI of the great thoracic vessels was successful in 12/16 fetuses (75%) by adopting clinical 4D flow MR protocols in combination with direct fetal cardiac DUS-gating. Four datasets were excluded due to artefacts by fetal movement or maternal breathing. 4D flow MRI–derived time-velocity curves revealed typical arterial blood flow patterns in the aorta. 4D flow quantification was achieved for the pre-defined target regions. Average velocity and flow volume were 21.1 ± 5.2 cm/s and 6.0 ± 3.1 mL/s in the AAo, 24.3 ± 6.7 cm/s and 8.4 ± 3.7 mL/s in the DAo, 21.9 ± 6.4 cm/s and 7.8 ± 4.2 mL/s in the MPA, and 23.4 ± 4.7 cm/s and 5.9 ± 3.6 mL/s in the DA, respectively.

Conclusions
Combination of DUS-gating of the fetal heart and 4D flow MRI allows comprehensive visualisation and quantification of haemodynamics in the fetal great thoracic vessels. DUS-gated fetal 4D flow MRI may provide a new diagnostic approach for prenatal assessment of blood flow haemodynamics.

Key Points
• Fetal cardiac Doppler-ultrasound (DUS) gating and 4D flow MRI can be successfully combined.
• DUS-gated fetal 4D flow MRI allowed visualisation and evaluation of streamline directionality, illustration of blood flow variations, and pulsatile arterial waveforms in the target vessels.
• 4D flow MRI–based visualisation and quantification of the fetal great thoracic vessels were successful and flow metrics agreed with echocardiographic reference values.
Intakes of major food groups in China and UK: results from 100,000 adults in the China Kadoorie biobank and UK biobank
Authors: Papier Keren , Kakkoura Maria G. , Guo Yu , Knuppel Anika , Pei Pei , Tong Tammy Y. N. , Yu Canqing , Perez-Cornago Aurora , Chang Wing Ching , Chen Junshi , Lv Jun , Li Liming , Chen Zhengming , Du Huaidong , Key Timothy J. 
Published: October 2022

Abstract
Purpose
Different populations may exhibit differences in dietary intakes, which may result in heterogeneities in diet–disease associations. We compared intakes of major food groups overall, by sex, and by socio-economic status (SES) (defined as both education and income), between participants in the China Kadoorie Biobank (CKB) and the UK Biobank (UKB).

Methods
Data were from ~ 25,000 CKB participants who completed a validated interviewer-administered computer-based questionnaire (2013–2014) and ~ 74,000 UKB participants who completed ≥ 3 web-based 24-h dietary assessments (2009–2012). Intakes of 12 major food groups and five beverages were harmonized and compared between the cohorts overall, by sex and by SES. Multivariable-adjusted linear regression examined the associations between dietary intakes and body mass index (BMI) in each cohort.

Results
CKB participants reported consuming more rice, eggs, vegetables, soya products, and less wheat, other staple foods (other than rice and wheat), fish, poultry, all dairy products, fruit, and beverages compared to UKB participants. Red meat intake was similar in both cohorts. Having a higher SES was generally associated with a higher consumption of foods and beverages in CKB, whereas in UKB dietary intakes differed more by education and income, with a positive association observed for meat and income in both UKB and CKB but an inverse association observed for education in UKB. Associations of dietary intakes with BMI varied between the two cohorts.

Conclusion
The large differences in dietary intakes and their associations with SES and BMI could provide insight into the interpretation of potentially different diet–disease associations between CKB and UKB.
How I do it: Cochlear Osia 2 System surgery placement
Authors: Soloperto Davide , Dallari Virginia , Molteni Gabriele 
Published: October 2022

Abstract
Background
The Cochlear™ Osia® 2 System is an active transcutaneous bone-anchored hearing implant with a newly developed piezoelectric transducer that is fixed to a titanium implant (BI300).

Methods
It uses digital piezoelectric stimulation to bypass non-functional areas of the natural hearing system and send sound directly to the cochlea. This device is designed to meet the needs of patients with unilateral and bilateral conductive or mixed hearing loss and single-sided deafness.

Conclusion
We show step by step how to place the new active transcutaneous bone conduction implant, Cochlear™ Osia® 2 System, which utilizes a piezoelectric actuator anchored to the mastoid bone through an osseointegrated screw.
Platelet lysate can support the development of a 3D-engineered skin for clinical application
Authors: Banakh I. , Rahman Md. M. , Arellano C. L. , Marks D. C. , Mukherjee S. , Gargett C. E. , Cleland H. , Akbarzadeh S. 
Published: October 2022

Abstract
Safety concerns associated with foetal bovine serum (FBS) have restricted its translation into clinics. We hypothesised that platelet lysate (PL) can be utilised as a safe alternative to produce serum-free 3D-engineered skin. PL supported a short-term expansion of fibroblasts, with negligible replication-induced senescence and directed epidermal stratification. PL-expanded fibroblasts were phenotypically separated into three subpopulations of CD90+FAP+, CD90+FAP− and CD90−FAP+, based on CD90 (reticular marker) and FAP (papillary marker) expression profile. PL drove the expansion of the intermediate CD90+ FAP+ subpopulation in expense of reticular CD90+FAP−, which may be less fibrotic once grafted. The 3D-engineered skin cultured in PL was analysed by immunofluorescence using specific markers. Detection of ColIV and LMN-511 confirmed basement membrane. K10 confirmed near native differentiation pattern of neo-epidermis. CD29- and K5-positive interfollicular stem cells were also sustained. Transmission and scanning electron microscopies detailed the ultrastructure of the neo-dermis and neo-epidermis. To elucidate the underlying mechanism of the effect of PL on skin maturation, growth factor contents in PL were measured, and TGF-β1 was identified as one of the most abundant. TGF-β1 neutralising antibody reduced the number of Ki67-positive proliferative cells, suggesting TGF-β1 plays a role in skin maturation. Moreover, the 3D-engineered skin was exposed to lucifer yellow on days 1, 3 and 5. Penetration of lucifer yellow into the skin was used as a semi-quantitative measure of improved barrier function over time. Our findings support the concept of PL as a safe and effective serum alternative for bioengineering skin for cell therapies.
H-DAC: discriminative associative classification in data streams
Authors: Seyfi Majid , Xu Yue 
Published: October 2022

AbstractIn this paper, we propose an efficient and highly accurate method for data stream classification, called discriminative associative classification. We define class discriminative association rules (CDARs) as the class association rules (CARs) in one data stream that have higher support compared with the same rules in the rest of the data streams. Compared to associative classification mining in a single data stream, there are additional challenges in the discriminative associative classification mining in multiple data streams, as the Apriori property of the subset is not applicable. The proposed single-pass H-DAC algorithm is designed based on distinguishing features of the rules to improve classification accuracy and efficiency. Continuously arriving transactions are inserted at fast speed and large volume, and CDARs are discovered in the tilted-time window model. The data structures are dynamically adjusted in offline time intervals to reflect each rule supported in different periods. Empirical analysis shows the effectiveness of the proposed method in the large fast speed data streams. Good efficiency is achieved for batch processing of small and large datasets, plus 0–2% improvements in classification accuracy using the tilted-time window model (i.e., almost with zero overhead). These improvements are seen only for the first 32 incoming batches in the scale of our experiments and we expect better results as the data streams grow.