bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pandemic Situation in Pakistan: Recoveries and Mortalities Rate of COVID-19 during First and Second Waves of Pandemic in Pakistan - Data from Feb to Dec 2020
Authors: Kalam Adil , Sadiqa Ayesha , Samad Javeria , Usman Muhammad , Yahya Saira 
Published: August 2022

The novel coronavirus disease COVID-19 outbreak has caused significant global issues and challenged healthcare systems across the globe and in Pakistan as well. This infectious disease is found to be a pandemic and has massively impacted countries across the world. The disease is still rapidly spreading and has caused many deaths in Pakistan, according to the world health organization; early in the year of 2020, Pakistan was ranked among the top 10 countries in the world reporting the highest number of new cases of COVID-19 per day during the first wave of the outbreak. The second wave of COVID-19 was relatively high on the first wave of disease in the current scenario of the pandemic. In the all over Pakistan, the real-time PCR is being applied for the qualitative detection of COVID-19 in the human nasopharyngeal swab specimen. From Feb to Dec.2020, in Pakistan there were a total of 416,499 cases registered across the country there have been (2%) deaths, with (85.2%) total recoveries. Sindh and Punjab were the most affected provinces; however, Balochistan, KPK, and other regions of Pakistan were less affected comparatively. This short communication is carried out to shed light on the coronavirus outbreak in the country; it will help to highlight the recoveries and mortalities rate of first and second waves of the disease.
Estimasi Nilai Gizi Pada Nugget Ikan Tuna Substitusi Sayuran
Authors: Juhartini_tini Juhartini_tini , Fadila Fadila 
Published: August 2022

Potensi sumber daya perikanan Indonesia, khususnya ikan tuna di Laut Provinsi Maluku Utara cukup besar. Sebagai komoditi yang bernilai ekonomis tinggi pemanfaatan sumber daya ikan tuna terus meningkat. Nugget ikan tuna substitusi sayuran merupakan produk nugget dari daging ikan tuna, daun kelor, wortel, dan seledri. Tujuan penelitian ini adalah untuk mengetahui nilai gizi pada nugget ikan tuna subtitusi sayuran. Jenis penelitian kuantitatif dengan desain penelitian Pra Ekpersimen. Penelitian ini dilaksanakan di Laboratorium Kimia Program Studi Gizi Poltekkes Ternate. Hasil perhitungan estimasi nilai gizi pada nugget ikan tuna subtitusi sayuran yaitu energi sebesar 2,743 kkal, protein sebesar 92,58 gram, lemak sebesar 105,24 gram, Karbohidrat sebesar 246,26 gram gram, air sebesar 837,02 ml ml, besi sebesar 20,52 mg dan Vitamin A sebesar 134,23 mg.Disarankan untuk melakukan uji kandungan gizi pada nugget ikan tuna subtitusi sayuran dilaboratorium agar mendapatkan hasil yang lebih akurat.
İBN TÛMERT’İN BİLGİ ANLAYIŞI
Authors: BOYNUEĞRİ Merve 
Published: August 2022

İbn Tûmert, Kuzey Afrika ve Endülüs coğrafyasında, Murabıtlar Devleti’nin yıkılıp yerine bir buçuk asır boyunca hüküm sürecek olan Muvahhidler Devleti’nin kurulmasını sağlamıştır ve bu nedenle Endülüs tarihini anlama noktasında önemli bir figürdür. İbn Tûmert, gençlik yıllarında ilim öğrenmek için Doğu’ya yolculuk yapmış ve geri döndüğünde ülkesindeki mevcut yönetimle ciddi bir mücadele içine girmiştir. Bu mücadelesinde de gerek kendisini mehdi ilan edip taraftar toplayarak gerekse savaşçı bir kitle oluşturup onları fiili bir mücadeleye hazırlamak suretiyle başarılı olmuştur.
İbn Tûmert siyasî kimliğinin yanı sıra, ilmî bir kimliğe de sahiptir. Görüşlerini çeşitli risalelerinde yazıya dökmüş, bunlar daha sonra Eʻazzu Mâ Yutlab adı altında birleştirilerek kitap haline getirilmiştir. Bu çalışma, Eʻazzu Mâ Yutlab bağlamında İbn Tûmert’in bilgi anlayışını ortaya koymayı amaçlamaktadır.
PENGABDIAN KEPADA MASYARAKAT USAHA KERIPIK SINGKONG “NYAMEN” RASA ORIGINAL (SPINNER MACHINE)
Authors: Oktriadi Yudi , Masdani Masdani , Afriadi Achmad 
Published: August 2022

Cassava chips are one of the typical light food products that are favored by valious levels of society. In the process of making cassava chips, many processes that are passed in the form of slicing cassava into thin, fried, dried/ drained, mixed with seasonings and as well as packaging. From a survey that has been carried out on partners, the drying process of cassava chips after frying is the main problem because the drying process still uses manual which is left to dry on an existing container and the drying process takes approximately 5-10 minutes with the number of chips being dried 2 -3 kg and done draining a lot of time. From this problem, as the proponent of the Educational Institution will make a cassava chip spice spinner machine that can replace human labor, so that capacity and time can be increased. Partners will get appropriate technology in the form of a cassava chip spinner machine and training on the process of using the machine and maintaining the machine. In addition, Partners will always receive maintenance services if the machine provided is disturbed or damaged. To achieve this goal, the Partners and the Service team agreed to propose to increase the quality and production capacity. The development of the production process is carried out by providing cassava chips dryer/spinner machine technology. With this machine, the results achieved with a total of 10 kg dried cassava chips in 10 minutes are met. So in conclusion, with the machine, partners can develop their business because they can meet market demand.
Kontrol Dan Monitoring Ph Air Pada Budidaya Lobster Air Tawar Dengan Metode PID Berbasis Internet Of Things
Authors: Putra Reynaldi Mahendra , Nurcahyo Sidik , Priyadi Bambang 
Published: August 2022

Saat ini di Indonesia, proses untuk mengontrol kadar keasaman (pH) air kolam pada budidaya lobster air tawar masih menggunakan cara manual yaitu dengan cara mengukur kadar keasaman (pH) air kolam dengan alat ukur pH meter. Apabila nilai pH air kolam tidak sesuai dengan parameter pH air yang telah ditentukan maka, dilakukan penambahan larutan yang dapat menetralkan pH air. Hal tersebut kurang efisien karena membuang banyak waktu dan tenaga. Untuk itu di ciptakan sebuah sistem yang dapat mengontrol pH air secara otomatis serta dapat memonitoring kadar pH air secara realtime melalui aplikasi blynk Agar dapat mengontrol Ph air yang baik dan tepat diperlukan metode kontrol PID. Kontrol PID digunakan untuk mengatur waktu aktifnya dosing pump peristaltic berdasarkan nilai error. Pada sistem ini menggunakan ESP32 sebagai mikrokontroller, Sensor pH, dosing pump peristaltic sebagai aktuator, serta LCD untuk menampilkan data. Berdasarkan hasil pengujian PID didapatkan dengan Kp=0.76,Ki=0.001 dan Kd=92.72 dengan hasil grafik respon sistem menunjukkan pada motor asam ketika nilai pH kolam 7,9 membutuhkan waktu selama 5580 s untuk mencapai set point.Kata Kunci : Lobster, pH, ESP32, Blynk, PID.
Implementasi Flow Sensor Pada Alat Pengisi Mase Otomatis Ke Dalam Cetakan Keramik
Authors: Bastarwan Jordiansyah , Patma Tundung Subali , Radianto Donny 
Published: August 2022

Keramik adalah suatu bentuk dari tanah liat yang telah mengalami proses pembakaran. Dalam proses pembuatan keramik terdiri dari beberapa proses yaitu pencetakan, pengeringan, dan pembakaran. Penelitian ini bertujuan untuk mendesain sebuah alat pengisi mase otomatis untuk mempermudah proses pencetakan keramik dengan menggunakan water flow sensor sebagai umpan balik alat. Water flow sensor pada alat ini digunakan untuk mengukur volume mase yang telah terisi pada cetakan keramik. Untuk dapat melakukan pengisian secara tepat digunakan kontrol akselerasi dan deselerasi pada motor servo. Besarnya volume mase pada cetakan keramik didasarkan pada trial and error dengan menggunakan water flow sensor pada setiap cetakan keramik. Alat ini menggunakan motor servo MG996R untuk mengatur pergerakan valve kran serta menggunakan arduino uno untuk memproses data. Pada pengujian yang dilakukan alat dapat membaca aliran mase dengan rata-rata error sebesar 1% dan waktu akselerasi dan deselerasi dapat diatur dari waktu 1-3 detik.
3D bioprinting of multi-layered segments of a vessel-like structure with ECM and novel derived bioink
Authors: Potere Federica , Belgio Beatrice , Croci Giorgio Alberto , Tabano Silvia , Petrini Paola , Dubini Gabriele , Boschetti Federica , Mantero Sara 
Published: August 2022

3D-Bioprinting leads to the realization of tridimensional customized constructs to reproduce the biological structural complexity. The new technological challenge focuses on obtaining a 3D structure with several distinct layers to replicate the hierarchical organization of natural tissues. This work aims to reproduce large blood vessel substitutes compliant with the original tissue, combining the advantages of the 3D bioprinting, decellularization, and accounting for the presence of different cells. The decellularization process was performed on porcine aortas. Various decellularization protocols were tested and evaluated through DNA extraction, quantification, and amplification by PCR to define the adequate one. The decellularized extracellular matrix (dECM), lyophilized and solubilized, was combined with gelatin, alginate, and cells to obtain a novel bioink. Several solutions were tested, tuning the percentage of the components to obtain the adequate structural properties. The geometrical model of the large blood vessel constructs was designed with SolidWorks, and the construct slicing was done using the HeartWare software, which allowed generating the G-Code. The final constructs were 3D bioprinted with the Inkredible + using dual print heads. The composition of the bioink was tuned so that it could withstand the printing of a segment of a tubular construct up to 10 mm and reproduce the multicellular complexity. Among the several compositions tested, the suspension resulting from 8% w/v gelatin, 7% w/v alginate, and 3% w/v dECM, and cells successfully produced the designed structures. With this bioink, it was possible to print structures made up of 20 layers. The dimensions of the printed structures were consistent with the designed ones. We were able to avoid the double bioink overlap in the thickness, despite the increase in the number of layers during the printing process. The optimization of the parameters allowed the production of structures with a height of 20 layers corresponding to 9 mm. Theoretical and real structures were very close. The differences were 14% in height, 20% internal diameter, and 9% thickness. By tailoring the printing parameters and the amount of dECM, adequate mechanical properties could be met. In this study, we developed an innovative printable bioink able to finely reproduce the native complex structure of the large blood vessel.
Liujunanwei decoction attenuates cisplatin-induced nausea and vomiting in a Rat-Pica model partially mediated by modulating the gut micsrobiome
Authors: Chen Dongmei , Guo Yi , Yang Yufei 
Published: August 2022

Studies show that traditional Chinese medicine (TCM), such as Liujunanwei (LJAW) decoction, can play important roles in alleviating side effects of chemotherapy. The purpose of this study was to understand how LJAW can counter chemotherapy-induced emesis via alteration of gut microbiota. We evaluated the effect of LJAW on cisplatin (DDP)-induced nausea and vomiting using a rat-pica model. Rats react to emetic-producing stimuli with increased kaolin consumption, a phenomenon called pica. The rats were injected with cisplatin and then randomly assigned to the control (DDP), Ondansetron or LJAW. The intake of kaolin and chow diet as well as body weights were recorded every 24 hours. Fecal samples were collected prior to, after three and seven days of treatment. The expression of proteins was measured by western blot. The concentration of cytokines and serotonin was evaluated using ELISA assay kits. Kaolin consumption in rats induced by cisplatin was reduced by 16.5%, 22.5%, and 30.1% in the LJAW group compared to the DDP group at 24 hours, 48 hours and 72 hours, respectively (p&gt;0.05). LJAW significantly increased the food intake of the rats (13.94 ± 4.73 g) during the first 24 hours as opposed to the DDP (9.23 ± 3.77 g) (p&lt;0.05). 16S rRNA gene sequencing showed the abundance of Bacteroidetes increased in cisplatin treated rats. In addition, cisplatin injection caused an enrichment of Escherichia-Shigella and Enterococcus at the genus level. While, enrichment of Blautia and Lactobacillus was presented in LJAW treated rats. Serotonin decreased in LJAW treated intestine and medulla oblongata tissues. Further, the protein expression of tryptophan hydroxylase 1 (TPH1) a rate limiting enzyme of serotonin was inhibited in LJAW treated rat’s jejunum compared with cisplatin only treated rats. In addition, LJAW downregulated chemotherapy induced elevated inflammation. The results of this study indicated that LJAW is capable of decreasing cisplatin-induced kaolin intake in rat-nausea model (pica), which might be mediated through gut microbiome-induced anti-inflammation and anti-serotonin synthesis functions.
Changes in intestinal microflora and its metabolites underlie the cognitive impairment in preterm rats
Authors: Lu Xiang , Xue Zhengyang , Qian Yu , Wei Shanjie , Qiao Yu , Zhang Wen , Lu Hongyan 
Published: August 2022

BackgroundThe brain development of preterm infants is easily affected by various adverse extrauterine factors and complications, resulting in abnormal neurological and cognitive development. Recent studies have found that there is a significant correlation between intestinal microbial changes and cognitive behavior. Nevertheless, the correlation between the cognitive impairment and abnormal changes of intestinal microflora in the preterm newborn has been rarely elucidated.AimTo analyze the differences of fecal intestinal flora, short chain fatty acids (SCFAs) and microbiota-gut-brain axis (MGBA)-related serum factors between preterm birth with and without cognitive impairment.MethodsHealthy female rats (body weight 410 ± 40 g) of 16-17 days of gestation were selected for the establishment of preterm cognitive impairment model and screened by Morris water maze navigation experiments. The pathological change of rat hippocampus was confirmed by HE staining. The abundance of fecal intestinal microflora was determined by 16sRNA sequencing, while the contents of fecal SCFAs were examined by gas chromatography.ResultsCompared with the control group, the cognitive impairment group had decreased abundance and diversity of intestinal microflora and increased abundance of Proteobacteria at the level of phylum. While the abundances of Alistipes, Bacteroides, Prevotella, and Lactobacillus decreased significantly at the level of order, family, and genus, the abundances of Staphylococcaceae, Enterococci, Psychrobacter, and Oligella increased significantly. Moreover, the levels of total SCFAs and acetic acid in the disease group were significantly lower. The fecal abundance of acetic acid was positively correlated with that of Lactobacillaceae or Peptostreptococcaceae, and negatively correlated with that of Aerococcaceae, and Alcaligenaceae in disease rats. Furthermore, cognitive impairment caused significantly decreased levels of 5-HT, GABA, and BDNF, and increased levels of GR, CRH, IL-6, and TNF-α in rat blood.ConclusionAlterations in intestinal microflora structure and the abundances of SCFAs contributed substantially to the cognitive impairment in preterm rats, which was associated with significant changes in MGBA-related soluble factors.
Vitamin K antagonists and cardiovascular calcification: A systematic review and meta-analysis
Authors: Kosciuszek Nina D. , Kalta Daniel , Singh Mohnish , Savinova Olga V. 
Published: August 2022

BackgroundMany patients treated with Vitamin K antagonists (VKA) for anticoagulation have concomitant vascular or valvular calcification. This meta-analysis aimed to evaluate a hypothesis that vascular and valvular calcification is a side-effect of VKA treatment.MethodsWe conducted a systematic literature search to identify studies that reported vascular or valvular calcification in patients treated with VKA. The associations between VKA use and calcification were analyzed with random-effects inverse variance models and reported as odds ratios (OR) and 95% confidence intervals (95% CI). In addition, univariate meta-regression analyses were utilized to identify any effect moderators.ResultsThirty-five studies were included (45,757 patients; 6,251 VKA users). The median follow-up was 2.3 years [interquartile range (IQR) of 1.2–4.0]; age 66.2 ± 3.6 years (mean ± SD); the majority of participants were males [77% (IQR: 72–95%)]. VKA use was associated with an increased OR for coronary artery calcification [1.21 (1.08, 1.36), p = 0.001], moderated by the duration of treatment [meta-regression coefficient B of 0.08 (0.03, 0.13), p = 0.0005]. Extra-coronary calcification affecting the aorta, carotid artery, breast artery, and arteries of lower extremities, was also increased in VKA treated patients [1.86 (1.43, 2.42), p &lt; 0.00001] and moderated by the author-reported statistical adjustments of the effect estimates [B: −0.63 (−1.19, −0.08), p = 0.016]. The effect of VKA on the aortic valve calcification was significant [3.07 (1.90, 4.96), p &lt; 0.00001]; however, these studies suffered from a high risk of publication bias.ConclusionVascular and valvular calcification are potential side effects of VKA. The clinical significance of these side effects on cardiovascular outcomes deserves further investigation.
Identification and Quantitative Characterization of Point Bars in Subsurface Meander-River Belt, Taking Chengdao Oilfield in Bohai Bay Basin as an Example
Authors: Yang Bin , Zhang Liqiang , Sun Zhifeng , Yan Yiming 
Published: August 2022

Reservoir architecture is an important basis for studying the sedimentary evolution of underground reservoirs and the distribution of remaining oil. Taking meander-river reservoir of Guantao Formation in Chengdao Oilfield as an example, characteristics of the evolution of subsurface meander-belt deposits were studied by seismic sedimentology. Seismic lithology is performed using -90° phase wavelet and frequency fusions; seismic geomorphology is conducted on seismic stratal slices. Six meandering belts were defined in the target layer, and the sediment at the bottom is characterized by the transformation from “braided” river to “meandering” river. The width of meander-river belt has no correlation with the maximum thickness of meander-river belt. But it has obvious negative correlation differences in the minimum thickness of meander–river belt. With the increase of width of the meander-river belt, the minimum thickness of the drilled meander-river belt decreases as a whole. The forward model based on the shape of point bar reveals the seismic architecture characteristics formed by the superposition of sand bodies at different positions of point bars. According to these characteristics, the point bars in the meandering zone can be explained. In the Ng33, Ng42, and Ng45 sub-layers of the study area, the corresponding meander-belt widths where the point bar (or point bar connecting body) cannot be effectively identified by well logging and seismic data, are, respectively, 800, 800, and 500 m. At the same time, when the width of the meander belt is greater than 1000 m, three or more than three point bars (or point bar connecting body) can be basically identified in the meander belt. The width of the point bar segments in the meander belt of the three main sub-layers is mostly 300–400 m, and the maximum width of the point bar segments is about 550 m, while the scale of point bars in Ng45 sub-layer meander belt is relatively small. The quantitative characteristics of point bar debris and the determined location of SBM and SIA sand bodies provide limited and valuable data support for the formation and simulation of underground meandering rivers, which are also useful for the model of the target reservoir.
SGLT2 inhibitor treatment is not associated with an increased risk of osteoporotic fractures when compared to GLP-1 receptor agonists: A nationwide cohort study
Authors: Al-Mashhadi Zheer Kejlberg , Viggers Rikke , Starup-Linde Jakob , Vestergaard Peter , Gregersen Søren 
Published: August 2022

BackgroundType 2 diabetes mellitus (T2D) is associated with an increased fracture risk. It is debated whether sodium-glucose cotransporter 2 (SGLT2) inhibitors influence fracture risk in T2D. We aimed to investigate the risk of major osteoporotic fractures (MOF) with SGLT2 inhibitors compared to glucagon-like peptide 1 (GLP-1) receptor agonists when used as add-on therapies to metformin.MethodsWe conducted a population-based cohort study using Danish national health registries. Diagnoses were obtained from discharge diagnosis codes (ICD-10 and ICD-8-system) from the Danish National Patient Registry, and all redeemed drug prescriptions were obtained from the Danish National Prescription Registry (ATC classification system). Subjects treated with metformin in combination with either SGLT2 inhibitors or GLP-1 receptor agonists were identified and enrolled from 2012 to 2018. Subjects were then propensity-score matched 1:1 based on age, sex, and index date. Major osteoporotic fractures (MOF) were defined as hip, vertebral, humerus, or forearm fractures. A Cox proportional hazards model was utilized to estimate hazard rate ratios (HR) for MOF, and survival curves were plotted using the Kaplan-Meier estimator.ResultsIn total, 27,543 individuals treated with either combination were identified and included. After matching, 18,390 individuals were included in the main analysis (9,190 in each group). Median follow-up times were 355 [interquartile range (IQR) 126-780] and 372 [IQR 136-766] days in the SGLT2 inhibitor and GLP-1 receptor agonist group, respectively. We found a crude HR of 0.77 [95% CI 0.56-1.04] for MOF with SGLT2 inhibitors compared to GLP-1 receptor agonists. In the fully adjusted model, we obtained an unaltered HR of 0.77 [95% CI 0.56-1.05]. Results were similar across subgroup- and sensitivity analyses.ConclusionThese results suggest that SGLT2 inhibitors have no effect on fracture risk when compared to GLP-1 receptor agonists. This is in line with results from previous studies.