bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation Gaps and Moral Distress in Culturally Responsive Care for Refugee and Migrant Maternal Health Services in New South Wales, Australia
Authors: Olcoń Katarzyna , Rambaldini-Gooding Delia , Degeling Chris 
Published: June 2022

Abstract
Background
Refugee and migrant women are at higher risk of childbirth complications and generally poorer pregnancy outcomes. They also report lower satisfaction with pregnancy care because of language barriers, perceived negative attitudes among service providers, and a lack of understanding of refugee and migrant women’s needs. This study juxtaposes health policy expectations in New South Wales (NSW), Australia on pregnancy and maternity care and cultural responsiveness and the experiences of maternal healthcare providers in their day-to-day work with refugee and migrant women.
Methods
This study used a qualitative framework method. Sixteen maternal health service providers who work with refugee and migrant women were recruited from two local health districts in New South Wales, Australia and interviewed (November 2019 to August 2020) about their experiences and the challenges they faced. In addition, a systematic search was conducted for policy documents related to the provision of maternal health care to refugee and migrant women on a state and federal level. Five policies were included in the analysis. The framework method matrix allowed for a comparison of providers’ experiences with the policy expectations.
Results
Framework analysis revealed structural barriers to culturally responsive service provision and the differential impacts of implementation gaps that impede appropriate care resulting in moral distress. Rather than being the programmatic outcome of well-resourced policies, the enactment of cultural responsiveness in the settings studied relied primarily on the intuitions and personal responses of individual service providers such as nurses and social workers.
Conclusion
Authentic culturally responsive care requires healthcare organisations to do more than provide staff training. To better promote service user and staff satisfaction and wellbeing, organisations need to embed structures to respond to the needs of refugee and migrant communities in the maternal health sector and beyond.
Development of p-y Curve Model for Sand Using Finite Element Analysis of Laterally Loaded Piles
Authors: Amirmojahedi Mohsen , Abu-Farsakh Murad , Voyiadjis George , Souri Ahmad 
Published: June 2022

Abstract
In this study, a 3-D finite element (FE) analysis was used for estimating the lateral capacity of piles driven in sand soils. The effects of different properties of the sand on the p-y curves were studied. Using the results of FE analysis, a model for predicting p-y curves for sandy soils was developed based on the pile shape, which is a combination of tangent hyperbolic and power functions. The results of the developed model were used to demonstrate its applicability in obtaining the p-y curves for the piles driven in sand soils having increase in modulus of elasticity with depth, in sand layers with different modulus of elasticity and unit weight, and at different overburden pressures. The results of the developed model were compared to the results of full-scale pile load test that was conducted at Mustang Island, which demonstrates the ability of the model for predicting the p-y curves and lateral behavior of piles in sandy soils with good accuracy. The results of this study showed that there is little reliability on the results obtained from Reese model, which is the most common method for obtaining lateral behavior of the piles. To consider uncertainties in soil properties due to pile installation, ranges of 0.5 to 1.0 and 1.0 to 2.0 for the value of K in the developed model were proposed for non-displacement and displacement piles, respectively.
First publication of endemic channels as part of a pediatric Antimicrobial Stewardship Program: when to turn on the alarms? Recommendations of a pediatric ASP program
Authors: Londoño-Ruiz Juan Pablo , Gutierrez-Tobar Ivan Felipe , Bermúdez-Bohórquez Naddya Lheidy , Rodriguez-Hernandez Andrea Esperanza 
Published: June 2022

Abstract
Background: Pediatric Antimicrobial Stewardship Programs (ASP) consider DOT a fundamental measure to quantify the impact of ASP. Novel strategies have been described, but no endemic channels (EC) have been reported to compare antibiotic use within historical patterns. This report describes the process of constructing an EC and analyzing its interpretation.Methods: This was a descriptive study of the construction, implementation, and analysis of EC. The median and quartile method, as well as the geometric mean (GM) and confidence interval (CI) methods using DOT for the last 4 years were used. ECs have also been elaborated on in critical services (PICU).Results: GM and CI method was more sensitive in identifying changes in antimicrobial use. Ceftriaxone increased its use starting in December 2021, reaching the warning zone in March 2022 in relation to increased cases of bacterial and complicated pneumonia. Piperacillin–tazobactam showed an important increase in PICU during the first 8 months of 2021, reaching the alert zone until August 2021; thereafter, its use decreased, and this variation was related to a modification in the presentation of complicated appendicitis during the COVID 19 pandemic restrictions. The use of ampicillin-sulbactam has increased since January 2022 because of a change in local guidelines regarding its use in appendicitis and peritonitis. The changes identified in each EC allowed ASP to take different conducts.Conclusion: EC allowed us to construct a new tool to measure ASP impact, internal comparison of antibiotic use facilitated taking timely interventions. EC could be useful for all pediatric and adult ASP.
Early embryonic development of Johnston´s Organ in the antenna of the desert locust Schistocerca gregaria
Authors: Boyan George , Ehrhardt Erica 
Published: June 2022

Abstract
Johnston´s organ has been shown to act as an antennal auditory organ across a spectrum of insect species. In the hemimetabolous desert locust Schistocerca gregaria, Johnston´s organ must be functional on hatching and so develops in the pedicellar segment of the antenna during embryogenesis. Here we employ the epithelial cell marker Lachesin to identify the pedicellar domain of the early embryonic antenna, and then triple-label against Lachesin, the mitosis marker phosphohistone-3, and neuron-specific horseradish peroxidase to reveal the sense-organ precursors for Johnston´s organ and their lineages. Beginning with a single progenitor at approximately a third of embryogenesis, additional precursors subsequently appear in both the ventral and dorsal pedicellar domains, each generating a lineage or clone. Lineage locations are remarkably conserved across preparations and ages, consistent with the epithelium possessing an underlying topographic coordinate system which determines the cellular organization of Johnston´s organ. By mid-embryogenesis twelve lineages are arranged circumferentially in the pedicel as in the adult structure. Each sense-organ precursor is associated with a smaller mitotically active cell from which the neuronal complement of each clone may derive. Neuron numbers within a clone increase in discrete steps with age, are invariant between clones and across preparations of a given age. At mid-embryogenesis each clone comprises five cells consolidated into a tightly bound cartridge. A long scolopale extends apically from each cartridge to an insertion point in the epithelium, and bundled axons project basally towards the brain. We review data from Drosophila to suggest mechanisms which might regulate the developmental program of Johnston´s organ in the locust.
Three Dimensional Evaluation of Changes in Mandibular Condyle Position After Orthognathic Surgery
Authors: Küçükçakır Osman , Cansız Erol , Yey Zeynep , Öztürk Merve 
Published: June 2022

Abstract
Background: This study aims to examine the changes in both mandibular condyle positions before and after surgery to evaluate manual temporomandibular joint (TMJ) positioning procedure after bilateral sagittal split ramus osteotomy in adult patients diagnosed with mandibular prognathism and compare them with the studies in the literature.Methods: Patients diagnosed with mandibular prognathism, including bilateral sagittal split ramus osteotomy (BSSRO) procedures, in addition to their orthodontic treatment, were examined. The study including the examination of 88 right and left mandibular condyles of 44 patients, 24 male and 20 female. This study focused on comparing retrospectively obtained cone-beam computed tomography data of patients for 1-2 weeks before surgery (T0) and a mean of six months postoperatively (T1). DICOM formats of cone-beam computed tomography data were analyzed in the 3D Slicer software program, considering the references of Choi et al.. The examination was made separately in the axial, sagittal and coronal planes. IBM® SPSS® Statistics was used for statistical analysis. After testing the homogeneity of variance and normality, the dependent sample t-test was applied at a 95% significance level.Results: The left mandibular condyle head rotated inward in the axial plane, but the change in the right condyle head was not statistically significant. In the sagittal plane, there was no significant change of both mandibular condyle heads. In the coronal plane, the right mandibular condyle head showed outward rotation, but the change in the left condyle head was not statistically significant. In addition, there was no statistically significant difference in the distance between the most medial points of the mandibular condyle heads in the coronal plane.Conclusions: The sagittal plane’s changes of the condyles can be maintained as before the surgery with manual positioning in bilateral sagittal split ramus osteotomy procedures. Inward and outward rotations seen in the axial and coronal planes are also consistent with the literature review. Stress occurring between the segments in the fixation process, operator positions during the operation, the direction and amount of the force applied for fixation, and contacts or gaps between the proximal and distal segments may be caused.
Deep Gaussian Convolutional Neural Network Model in Classification of Cassava Diseases using Spectral Data
Authors: Ahishakiye Emmanuel , Mwangi Waweru , Muthoni Petronilla , Fredrick Kanobe , Owomugisha Godliver , Danison Taremwa , Nkalubo Leonard 
Published: June 2022

Abstract
Early disease identification in crops is critical for food security, especially in Sub-Saharan Africa. To identify cassava diseases, professionals visually score the plants by looking for disease indicators on the leaves which is notoriously subjective. Automating the detection and classification of crop diseases could help professionals diagnose diseases more accurately and allow farmers in remote locations to monitor their crops without the help of specialists. Machine learning algorithms have been used in the early detection and classification of crop diseases. However, traditional machine learning algorithms are not calibrated even though they have high accuracy. The ability to provide well-calibrated posterior distributions is one of the most appealing properties of Gaussian processes. Motivated by the current developments in the field of Gaussian Processes, this study proposed a deep Gaussian convolutional neural network model (DGCNN) for the detection and classification of cassava diseases using spectral data. The proposed model uses a hybrid kernel function that is the product of a rational quadratic kernel and a squared exponential kernel. Experimental results revealed that our proposed hybrid kernel function performed better in terms of accuracy of 90.10% when compared to both the squared exponential kernel with an accuracy of 88.01% and the rational quadratic kernel with an accuracy of 88.52%. In our future work, we propose to integrate the Optimised model proposed in this study with the transfer learning approach, a move that may help to improve the model performance.
Greenhouse gas emissions and their relationship with hydropower generation in a tropical reservoir in Colombia
Authors: Usuga Fabian A. , Rodriguez Diana C. , Peñuela Gustavo A. 
Published: June 2022

Abstract
Studies of emissions of greenhouse gas (GHG) such as CO2 and CH4 in hydroelectric reservoirs are very important in the debate on whether hydropower can be classified as a ‘clean energy’ source. In this study, GHG emissions in the Topocoro reservoir in Colombia during the first five years after filling were evaluated and related with hydropower generation. The floating static chamber and inverted funnel methodology were used for the collection of GHG and the gas chromatography with flame ionization detector (FID) – methanizer and electron capture detector (ECD) methodology for its detection in the laboratory. The results showed emission values between 256,613 and 654,643 tCO2eq/year. The intensity of gases was also determined in a range between 81 and 148 gCO2eq/kWh, depending on the evolution of the filling and the power generation in the reservoir. The results suggested that as the filling percentage of the surface of the reservoir increases, there will be more GHG emissions, due to the biotic and abiotic decomposition of organic matter. At the same time, higher energy production will be generated.
Orthogonally Protected N-Methyl-Substituted α-Aminoglycines
Authors: Jiang Guangcheng , Simon Lajos , Rivier Jean E. 
Published: June 2022

Abstract:
Title glycine derivatives FmocNRlCH(NR2Boc)CO2H (I; Fmoc =9-fluorenyl-methyloxycarbonyl; Boc =
Me3CO2C; Rl = H, Me; R2 = H, Me), useful as templates for the introduction of desired functionalities into
peptides, were prepared by condensation of glyoxylic acid and carbamates Fmoc-NH-Rl (Rl = H, Me), followed
by conversion with Me2CHSH of the resulting FmocNRlCH(OH)CO2H to FmocNR1CH(SCHMe2)CO2H (Rl =
H, Me) which were further treated with Boc-NH-R2 (R2 = H, Me) in the presence of N-bromosuccinimide. A simple and efficient synthesis of Fmoc-NH-Me and Boc-NH Me is also reported.
Barstar Inhibits Extracellular Ribonucleases of Streptomyces and Allows their Production from Recombinant Genes
Authors: Hartley Robert W. , Both Valentin , Hebert Eric J. , Homerova Dagmar , Jucovic Milan , Nazarov Viktor , Rybajhak Igor , Sevcik Jozef 
Published: June 2022

Abstract:
Barstar, the intracellular protein of Bacillus amyloliquefaciens which binds to and inhibits barnase, the extracellular ribonuclease of the same organism, has been found to bind to and inhibit also the homologous ribonucleases of several Streptomyces strains. The ribonucleases of four strains of streptomyces have been produced from recombinant or synthetic genes on plasmid vectors in E. coli. Sequence identity among these enzymes is from 49% to 69%. Sequence identities to barnase are no more than 25%.
Molecular Insights on Selective and Specific Inhibitors of Cyclin Dependent Kinase 9
Enzyme (CDK9) for the Purpose of Cancer Therapy
Authors: Kumar Dileep , Karati Dipanjan , Mahadik Kaka Saheb Ramoo , Trivedi Piyush 
Published: June 2022

Abstract:
Cyclin Dependent Kinase 9 (CDK9), which controls transcriptional elongation, is a promising pharmacological target for a variety of cancerous cells, specifically those characterized by transcriptional dysregulation. CDK9 promotes the pause or release of RNA polymerase II, a rate-limiting stage in normal transcriptional regulation that is often disturbed in cancers. New indications suggest that selective CDK9 antagonism may be beneficial in the treatment of some cancers. CDK9 modulators (inhibitors and degraders) have gotten a lot of attention recently, and many molecules are currently in clinical trials. In this review, the CDK9 antagonists under clinical and preclinical trials have been discussed, as well as the structure-activity relationship has been studied, which will help scientists generate more target-specific drug molecules in the future with less toxicity.
Natural Agents Targeting Hsp90 Co-chaperones could be Promising Candidates
for Viral Resistance Prevention
Authors: Quan Yuan , Lv Bo-Min , Zhang Hong-Yu 
Published: June 2022

Abstract:
Viral infections have constituted a serious menace to global health. The emergence of resistant strains resulting from adaptive evolution poses a great challenge to virus control. Heat shock protein 90 (Hsp90) can shepherd virus-mutated proteins to fold into functional conformations. Therefore, inhibiting Hsp90 can block the evolution of viruses. However, none of the current Hsp90 inhibitors has been approved because of the unacceptable side effects. Considering the importance of co-chaperones for Hsp90 conformational cycle, inhibiting Hsp90 through co-chaperones may be a safe and effective strategy. Some natural agents can bind the co-chaperones to indirectly modulate Hsp90 activity with low toxicity. Besides, some of these natural agents indicate antiviral effects. Therefore, natural products are highly expected to be used as virus resistance preventives through targeting the co-chaperones of Hsp90.
Targeting Breast Cancer in Diabetic Mice Using a Combination of
Thymoquinone and Metformin
Authors: Aboulqassim Naeimah S. Sulayman , Talib Wamidh H. 
Published: June 2022

Objective:
The aim of our study was to assess thymoquinone (TQ) as a combination therapy
with metformin (MT) against breast cancer in diabetic tumor-bearing mice.

Method:
The antiproliferative activities of TQ and MET and their combination were tested against
three breast cancer cell lines (EMT6/P, T47D, MDA-MB-231) using an MTT assay. We used the
isobolographic method to calculate the combination index (CI). Balb/C mice were implanted with
EMT6/P cells and diabetes was induced using Streptozotocin (STZ). The antitumor activity was
assessed for TQ and MET and their combination in vivo. The antiangiogenic activity and apoptosis
induction ability of TQ and MET were estimated using ELISA kits. To estimate the liver and kidney
functions, aspartate transaminase (AST), alanine transaminase (ALT) levels, and creatinine were
detected in serum samples using standard kits. The impact of the TQ and MET combination on reducing
blood glucose levels was measured daily using a glucometer.

Results:
Synergistic anticancer effect was observed between TQ and MET. The combination of TQ
and MET caused a significant reduction in tumor size (p value <0.05) with a high cure percentage of
(71.42%) and lower blood glucose levels. The combination therapy induces apoptosis, inhibits angiogenesis,
and causes tumor regression. Moreover, no significant effect was observed in the serum
levels of AST, ALT, and creatinine, as the values were very close to the normal ones.

Conclusion:
The combination of TQ and MET is considered a promising anticancer therapy to treat
breast cancer induced by diabetes and nondiabetes mice. This combination possesses antiproliferative
activity, anti-hyperglycemic activity, inhibits angiogenesis and induces apoptosis. Furthermore,
this combination demonstrated low toxicity.
Investigations on Force Characteristics of Orbiting Scroll in Asymmetricsuction Scroll Compressors
Authors: Sun Shuaihui , Song Zhe , Guo Pengcheng , Wang Xianwen , Zhang Bo , Mao Zhenkai 
Published: June 2022

Background:
Scroll refrigeration compressors are the critical equipment for the refrigeration
system in air conditioners and vehicles. The asymmetric suction structure can be applied to reduce the
scroll compressors' size. However, the pressure difference between the symmetric working chambers
becomes larger and leads to the special force characteristics of the orbiting scroll.

Objective:
This paper illustrates the force characteristics of the orbiting scroll in an Asymmetric-suction
Scroll Compressor (ASC) to improve its stability and reliability

Methods:
The theoretical model has been established to calculate the force and moment acting on the
orbiting scroll of ASC and the Symmetric-suction Scroll Compressor (SSC) based on the transient numerical
simulation results.

Results:
The variations of gas force and moment in ASC and SSC are displayed and compared. Their
pulsation intensities are calculated and discussed.

Conclusion:
The pressure in the outer compression chamber of ASC was always higher than that in the
inner compression chamber, which caused significant discharge loss. Affected by the tangential leakage
flow, the radial force of the compressor fluctuated sharply. As the tangential force on the orbiting scroll
segments of symmetrical working chambers in ASC led to the negative spin moment, the total average
spin-torque decreased by 71.3%. Still, the pulsation intensity increased by ten times. Furthermore, the
direction of the spin moment reversed at 275°~355°, which indicated that the orbiting scroll impacted
the Oldham ring every rotation. The noise and vibration would happen, and the Oldham ring would be
damaged easily.
Building and Implementing a Quality Assurance/Quality Improvement
Program for Clinical Research
Authors: Bruns Reva , Barton-Baxter Marietta , Poskin Roxane , Kern Philip A. , Stoops William W. 
Published: June 2022

Background:
A major goal of the Clinical and Translational Science Award programs is
to build and grow clinical and translational research, including the need to ensure that study teams
are educated and adhere to best clinical research practices.

Objective:
One of the primary objectives of the Center for Clinical and Translational Science at the
University of Kentucky is to help investigators implement standard operating procedures and provide
resources to conduct clinical research that is rigorous, ethical, and safe.

Methods:
The University of Kentucky Center for Clinical and Translational Science sought to establish
a Quality Assurance/Quality Improvement program for Principal Investigator (PI) initiated
clinical research studies using Center for Clinical and Translational Science services. Initiated in
2011, this program’s goal was to improve research design quality and, from the start of the project,
“find it, fix it”, leading to improved PI education without being viewed as punitive.

Results:
Since the initiation of our Quality Assurance/Quality Improvement program, PI acceptance
has been good and we have expanded its footprint and adjusted our review style to better
match the needs of our PIs. This article discusses our experiences with Quality Assurance/Quality
Improvement program development and growth.

Conclusion:
A Quality Assurance/Quality Improvement program can be developed that is efficient,
effective, educational, and well accepted by all clinical research stakeholders.