bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration of HIV prevention and sexual and reproductive health in the era of anti-retroviral-based prevention: findings from assessments in Kenya, Malawi and Zimbabwe
Authors: Kachale Fannie , Mahaka Imelda , Mhuriro Fatima , Mugambi Mary , Murungu Joseph , Ncube Barbra , Ncube Getrude , Ndwiga Albert , Nyirenda Rose , Otindo Violet , Carter Anna , Dunbar Megan , Fleischman Janet , Rodrigues Jessica , Segal Kate 
Published: March 2022

Background: Though substantial progress has helped curb the HIV epidemic, high rates of new HIV infections persist among adolescent girls and young women (AGYW) in sub-Saharan Africa, reflecting critical gaps in reaching them with integrated HIV prevention and sexual and reproductive health (SRH) services. The scale-up of oral pre-exposure prophylaxis (PrEP) and multiple novel HIV prevention products on the horizon offer countries a unique opportunity to expand innovative approaches to deliver comprehensive, integrated HIV prevention/SRH services. Methods: This article comparatively analyzes findings from rapid assessments in Kenya, Malawi and Zimbabwe across key themes to highlight cross-country trends and contextual realities around HIV prevention/SRH integration, with a focus on oral PrEP and contraception. In Kenya and Zimbabwe, assessments were completed by Ministries of Health (MOH) and the HIV Prevention Market Manager and include 20 health facility assessments, 73 key informant interviews (KIIs) and six community dialogues. In Malawi, the assessment was completed by the MOH and Georgetown University Center for Innovation in Global Health and includes 70 KIIs and a review of national policies and program implementation in Blantyre. Findings were contextualized through a review of literature and policies in each country. Results: Across countries, the policy environment is conducive to HIV prevention/SRH integration, though operationalization presents ongoing challenges, with most policies preceding and not accounting for oral PrEP rollout. National coordination mechanisms, youth-friendly health services and prevention of mother-to-child transmission programs are promising practices, while siloed and resource-constrained health systems, limited provider capacity, underfunded demand generation and structural factors exacerbate barriers to achieving integration. Conclusions: As new HIV prevention products are introduced, demand for integrated HIV prevention/SRH services is likely to grow. Investing in HIV prevention/SRH integration can help to ensure a sustainable response to the HIV epidemic, streamline service delivery and improve the health outcomes and lives of AGYW.
Methodology of Natsal-COVID Wave 1: a large, quasi-representative survey with qualitative follow-up measuring the impact of COVID-19 on sexual and reproductive health in Britain
Authors: Dema Emily , Copas Andrew J , Clifton Soazig , Conolly Anne , Blake Margaret , Riddell Julie , Boso Perez Raquel , Tanton Clare , Bonell Chris , Sonnenberg Pam , Mercer Catherine H , Mitchell Kirstin R , Field Nigel 
Published: March 2022

Background: Britain’s National Surveys of Sexual Attitudes and Lifestyles (Natsal) have been undertaken decennially since 1990 and provide a key data source underpinning sexual and reproductive health (SRH) policy. The COVID-19 pandemic disrupted many aspects of sexual lifestyles, triggering an urgent need for population-level data on sexual behaviour, relationships, and service use at a time when gold-standard in-person, household-based surveys with probability sampling were not feasible. We designed the Natsal-COVID study to understand the impact of COVID-19 on the nation’s SRH and assessed the sample representativeness. Methods: Natsal-COVID Wave 1 data collection was conducted four months (29/7-10/8/2020) after the announcement of Britain’s first national lockdown (23/03/2020). This was an online web-panel survey administered by survey research company, Ipsos MORI. Eligible participants were resident in Britain, aged 18-59 years, and the sample included a boost of those aged 18-29. Questions covered participants’ sexual behaviour, relationships, and SRH service use. Quotas and weighting were used to achieve a quasi-representative sample of the British general population. Participants meeting criteria of interest and agreeing to recontact were selected for qualitative follow-up interviews. Comparisons were made with contemporaneous national probability surveys and Natsal-3 (2010-12) to understand bias. Results: 6,654 participants completed the survey and 45 completed follow-up interviews. The weighted Natsal-COVID sample was similar to the general population in terms of gender, age, ethnicity, rurality, and, among sexually-active participants, numbers of sexual partners in the past year. However, the sample was more educated, contained more sexually-inexperienced people, and included more people in poorer health. Conclusions: Natsal-COVID Wave 1 rapidly collected quasi-representative population data to enable evaluation of the early population-level impact of COVID-19 and lockdown measures on SRH in Britain. Although sampling was less representative than the decennial Natsals, Natsal-COVID will complement national surveillance data and Natsal-4 (planned for 2022).
Whole genome sequence analysis of Salmonella Typhi in Papua New Guinea reveals an established population of genotype 2.1.7 sensitive to antimicrobials
Authors: Dyson Zoe Anne , Malau Elisheba , Horwood Paul F. , Ford Rebecca , Siba Valentine , Yoannes Mition , Pomat William , Passey Megan , Judd Louise M. , Ingle Danielle J. , Williamson Deborah A. , Dougan Gordon , Greenhill Andrew R. , Holt Kathryn E. 
Published: March 2022

Background
Typhoid fever, a systemic infection caused by Salmonella enterica serovar Typhi, remains a considerable public health threat in impoverished regions within many low- and middle-income settings. However, we still lack a detailed understanding of the emergence, population structure, molecular mechanisms of antimicrobial resistance (AMR), and transmission dynamics of S. Typhi across many settings, particularly throughout the Asia-Pacific islands. Here we present a comprehensive whole genome sequence (WGS) based overview of S. Typhi populations circulating in Papua New Guinea (PNG) over 30 years.

Principle findings
Bioinformatic analysis of 86 S. Typhi isolates collected between 1980–2010 demonstrated that the population structure of PNG is dominated by a single genotype (2.1.7) that appears to have emerged in the Indonesian archipelago in the mid-twentieth century with minimal evidence of inter-country transmission. Genotypic and phenotypic data demonstrated that the PNG S. Typhi population appears to be susceptible to former first line drugs for treating typhoid fever (chloramphenicol, ampicillin and co-trimoxazole), as well as fluoroquinolones, third generation cephalosporins, and macrolides. PNG genotype 2.1.7 was genetically conserved, with very few deletions, and no evidence of plasmid or prophage acquisition. Genetic variation among this population was attributed to either single point mutations, or homologous recombination adjacent to repetitive ribosomal RNA operons.

Significance
Antimicrobials remain an effective option for the treatment of typhoid fever in PNG, along with other intervention strategies including improvements to water, sanitation and hygiene (WaSH) related infrastructure and potentially the introduction of Vi-conjugate vaccines. However, continued genomic surveillance is warranted to monitor for the emergence of AMR within local populations, or the introduction of AMR associated genotypes of S. Typhi in this setting.
Comparative analysis of the results of surgical correction of idiopathic thoracic scoliosis in patients with active bone growth
Authors: Chernyadjeva M. A. , Vasyura A. S. , Lukinov V. L. , Novikov V. V. 
Published: March 2022

Objective. To conduct a comparative analysis of surgical treatment results for idiopathic thoracic scoliosis in patients during active bone growth and to identify the most effective methods of scoliosis correction for the considered age group.Material and Methods. The results of surgical treatment of 343 patients aged 10–14 years with continued active growth and progressive idiopathic thoracic scoliosis were analyzed. The patients were operated on in 1998–2018 using five surgical techniques: hybrid fixation with and without anterior stage, transpedicular fixation, and laminar fixation with and without anterior stage.Results. Statistically significant deformity progression was observed in patients operated on using laminar (Group IV) and hybrid (Group I) fixation. An additional anterior stage (discectomy and interbody fusion) in combination with laminar fixation (Group V) does not prevent deformity progression after surgery. In patients who underwent hybrid fixation in combination with the anterior stage (Group II) or total transpedicular fixation (Group III), no statistically significant progression of scoliotic deformity was observed in the postoperative period. Patients operated on with total transpedicular fixation (Group III) show improvement in all domains of the SRS-24 questionnaire: no increase in pain throughout the entire follow-up period, higher assessment of appearance after surgery and satisfaction with the treatment result. In groups II and III, there was no negative dynamics of topographic parameters in the long-term period after treatment; the initial correction of the deformity was maintained throughout the entire postoperative follow-up.Conclusion. Total transpedicular fixation provides the best correction of scoliosis in the absence of progression in the long-term postoperative follow-up in children during the period of active bone growth (age 10–14 years). According to the survey data, patients operated on with total transpedicular fixation demonstrate improvement in the following domains: the absence of pain syndrome throughout the entire postoperative follow-up period, the highest assessment of appearance after surgery and satisfaction with the result of surgical treatment. Hybrid fixation in combination with the anterior stage and total transpedicular fixation ensure the absence of negative dynamics of topographic parameters in the long term after surgery with maintenance of the initial surgical correction of spinal deformity.
Russian-Ukraine 2022 War: A Review of the Economic Impact of Russian-Ukraine Crisis on the USA, UK, Canada, and Europe
Authors: Mbah Ruth Endam , Wasum Divine 
Published: March 2022

The popular belief worldwide is that the global financial sanctions unleashed on Russia, the seizure of assets and properties of the oligarch friends to President Putin for Russia’s current attack on Ukraine will cripple the Russian economy and hinder any further attack on Ukraine. This is logical reasoning, however, the impact of this crisis extends to the global economy. Thus, the purpose of this study is to review the economic impact of the 2022 Russia-Ukraine war on key global economic actors, specifically, countries that have unleashed financial sanctions on Russia as punishment like the USA, Canada, UK, and EU. This study uses the Social Contract and the Interest Group Theories to explain the rationale behind this crisis from its origin. Evidence from reviewed literature shows that although the consequences of this crisis have had a fatal impact on Russia’s economy, the world economy has begun to feel the impact of this crisis. Inflation which is already ravaging most global economies is steadily rising due to the sharp increase in oil, natural gas, and food prices just a few days into this crisis. Experts expect a negative impact on household consumption, increase uncertainty, unpredictable stock swings, supply chain disruptions, bulging utility bills, decreased investment due to political risks, and economic growth impediments. It is therefore vital for policymakers worldwide to seek alternative means of survival if Russia decides to react by restricting its export of vital global commodities of which it is a significant export leader like oil, natural gas, wheat, neon, titanium, palladium, and ammonium nitrate.
Comparison of VIS/NIR spectral curves plus RGB images with hyperspectral images for the identification of Pterocarpus species
Authors: Wang Cheng-Kun , Zhao Peng , Li Zhen-Yu , Li Xiang-Hua 
Published: March 2022

Abstract
The image information and spectral information of wood sections can be used to identify wood species. Hyperspectral images have both image information and spectral information, but they have disadvantages such as large data capacity, slow reading speed, and the necessity of expensive equipment for their acquisition. In this study, the classification results of Pterocarpus by using visible/near infrared (VIS/NIR) spectral information and RGB images were compared with hyperspectral images. The VIS/NIR spectral curves, Hyperspectral, and RGB images of five wood species of Pterocarpus with similar transverse-sections were collected. In feature-level fusion, the feature vectors are directly connected in series, and features fused by canonical correlation analysis are compared. In decision-level fusion, an extreme learning machine and a composite-kernel support vector machine (SVM) are used and compared. In the feature- and decision-level fusion methods, the recognition results of VIS/NIR spectral curves plus RGB images were largely similar to those of hyperspectral images. Therefore, a recognition effect similar to that of the hyperspectral image can be obtained by collecting the spectral information and image information of wood sections separately, which can reduce the cost of data acquisition and improve the speed of data processing.
On the excitation and radiative decay rates of plasmonic nanoantennas
Authors: Bedingfield Kalun , Demetriadou Angela 
Published: March 2022

Abstract
Plasmonic nanoantennas have the ability to confine and enhance incident electromagnetic fields into very sub-wavelength volumes, while at the same time efficiently radiating energy to the far-field. These properties have allowed plasmonic nanoantennas to be extensively used for exciting quantum emitters—such as molecules and quantum dots—and also for the extraction of photons from them for measurements in the far-field. Due to electromagnetic reciprocity, it is expected that plasmonic nanoantennas radiate energy as efficiently as an external source can couple energy to them. In this paper, we adopt a multipole expansion (Mie theory) and numerical simulations to show that although reciprocity holds, certain plasmonic antennas radiate energy much more efficiently than one can couple energy into them. This work paves the way towards designing plasmonic antennas with specific properties for applications where the near-to-far-field relationship is of high significance, such as: surface-enhanced Raman spectroscopy, strong coupling at room temperature, and the engineering of quantum states in nanoplasmonic devices.
Numerical and experimental investigations of tip clearance effects in a high-flow-coefficient centrifugal compressor
Authors: Zhao Chenxi , Yang Changling , Zhang Chenqing , Zhang Xiaotian , Xi Guang 
Published: March 2022

Abstract
This paper focuses on the investigation of the blade deformation and tip clearance effects of a high-flow-coefficient centrifugal compressor. Blade deformation caused by the pressure load and centrifugal load under operating condition is considered by fluid/solid interaction method to simulate the stage performance accurately. Hence the numerical results are in good agreement with the experimental data. The blade deformation is then analyzed in detail. Also, the effect of the size of tip clearance is studied by evaluating the performance with five various gaps. The result shows that the increment of the tip clearance from 0 to 2.0 mm leads to a 5.14% peak efficiency decline. However, increasing tip gap contributes to enlarge the stable operating range in terms of stall margin and choke margin.
MENINGKATKAN PEMAHAMAN PESERTA DIDIK MELALUI PEMBELAJARAN REMEDIAL METODE TUTOR SEBAYA PADA MATA PELAJARAN MATEMATIKA DI KELAS XII MIA 3 MAN 2 TANAH DATAR TAHUN PELAJARAN 2018/2019
Authors: Diana Pesma , Fitriza Rozi 
Published: March 2022

This research is focusing on the efford to enhance students’s understanding, especially for those who have not complete the minimum mark attainment, through peer teaching remedial learning at 12th Natural Science 3 class, academic year 2018/2019. This is an action class research. Data in this research are qualitative dan quantitative. Qualitative data were gained throughobservation towards students’s activities during peer theaching remedial learning process and through interview. While quantitative data were gathered from daily score and from the test after treatment finishing. The result of the research showed that there is an improvement of students’s understanding through the peer teaching activity. It is showed by the higher percentage of students’s who could reach the minimum score attainment in one basic competence, and it was revealed that students were more active and enthusiastic to ask questions and explanations to their while the remedial teaching took place.
PENGARUH GAYA KEPEMIMPINAN KEPALA SEKOLAH TERHADAP EFEKTIVITAS SEKOLAH PADA SEKOLAH MENENGAH KEJURUAN NEGERI DI PROVINSI JAMBI
Authors: Istikomah Istikomah 
Published: March 2022

Principal's leadership is one of the supports success of a school to be an effective school. Being an effective school there needs to be a strong headmaster's leadership because the meaning of leadership is one's attitude to be able to influence others in order to work according to their responsibilities and achieve desired goals. This research is quantitative research with a survey method. From the results of this study, it was found that the principal's leadership style significantly influenced the effectiveness of schools in the State Vocational High School in Jambi Province. Based on the results of the analysis, the obtained value of thitung (8,54) > ttabel (1,969), H0 is rejected and H1 is accepted. This means that the high leadership style of the principal has a significant influence on school effectiveness. This means that the extent effectiveness of application the principal's leadership style will result, increase in school effectiveness. The research implications of these findings explain that better the principal's leadership style, more influential school's effectiveness will be.
Safety, pharmacokinetics and pharmacodynamics of an original glycoprotein IIb/IIIa inhibitor in healthy volunteers: results of the clinical trial
Authors: Fitilev S. B. , Glukhov Yu. F. , Lukyanov S. V. , Vozzhaev A. V. , Shkrebniova I. I. , Kazey V. I. , Bondareva I. B. 
Published: March 2022

Aim. To study the tolerability, safety, pharmacokinetics (PK) and pharmacodynamics of single intravenous infusions of Angipur in healthy male volunteers.Material and methods. The Phase I trial included 20 healthy male volunteers (mean age, 30,8±7,7 years; mean body weight, 77,4±12,1 kg). Angipur (0,02% concentrate for solution for infusion) was administered to every subject in single doses 0,015, 0,05, 0,09 mg/kg for 3 consecutive days. Volunteers were divided in 6 groups (1, 1, 3, 5, 5, 5); every following group was recruited only after the previous one finished the study. The following were assessed: rate and severity of adverse events (AEs), key PK parameters of Angipur and its antiplatelet activity by impedance aggregometry.Results. No moderate or severe AEs, as well as no serious AEs were reported according to obtained data of clinical and laboratory monitoring of healthy subjects. Totally 6 mild AEs were registered in 4 subjects. Four AEs (mild hematological deviations and episode of nose bleed) were classified as possibly related to study drug and 1 AE (positive fecal occult blood test) — probably related. Key PK parameters of Angipur in single intravenous doses 0,015, 0,05 и 0,09 mg/kg were determined as follows: Cmax — 12,44±4,689, 46,10±14,295, 92,48±33,896 ng/ml; Vd — 304,01±55,300, 299,67±64,244, 252,96±47,790 l; T1/2 — 6,72±1,290, 6,84±2,341, 6,06±2,287 h; Cl — 32,19±6,919, 32,29±8,357, 31,55±10,113 l/h, respectively. Dose proportionality (linear PK) for parameters Cmax, AUC0-t and AUC0-∞ was established. Dose-dependent reduction of ADP-induced platelet aggregation degree and area under curve was revealed at period of 15 min to 2-4 h after Angipur infusion in doses 0,05 and 0,09 mg/kg.Conclusion. Results of phase I clinical trial demonstrated good tolerability of single intravenous infusions of Angipur (0,015, 0,05 и 0,09 mg/kg) in healthy subjects. We determined key PK parameters and indicated dose-dependent antiplatelet activity of Angipur.
Correlation between markers of fibrosis and myocardial remodeling in patients with various course of hypertrophic cardiomyopathy
Authors: Bogatyreva F. M. , Kaplunova V. Yu. , Kozhevnikova M. V. , Shakaryants G. A. , Privalova E. V. , Belenkov Yu. N. 
Published: March 2022

Aim. To assess the relationship between fibrosis markers and structural and functional parameters in patients with various types of hypertrophic cardiomyopathy (HCM).Material and methods. This prospective comparative non-randomized study included 49 patients with HCM. Patients were divided into 3 groups according to the disease course: group 1 — stable course (n=12; men, 8 (67%), mean age ‒ 41±12 years); group 2 — progressive course (n=26; men, men, 16 (61%). mean age — 57±11 years); group 3 — patients with atrial fibrillation (AF) (n=11; men, 4 (36%), mean age — 63±6 years). Patients underwent standard clinical and paraclinical investigations. The levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) were determined in all patients using enzyme-linked immunosorbent assay in blood serum.Results. In all patients with HCM, elevated levels of MMP-9 and TIMP-1 are noted compared to the reference values. In group 1, the MMP-9 level [Me (Q1; Q3)] was 226 (201;271) ng/ml; TIMP-1 — 410 (267;488) ng/ml; in group 2, the MMP-9 level was 236 (187;285) ng/ml; TIMP-1 — 421 (321;499) ng/ml. In the course with AF, the MMP-9 level was 260 (228;296) ng/ml, while TIMP-1 — 381,5 (305;466) ng/ml; no significant difference was revealed (p=0,59; p=0,90, respectively). A correlation was found between age and MMP-9 levels, as well as between MMP-9 levels and left atrial volume (p=0,034; p=0,035, respectively).Conclusion. The high activity of matrix metalloproteinases and their tissue inhibitors reflects enhanced fibrosis and myocardial remodeling in HCM, which is especially characteristic of patients with AF.