bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual water-electricity cooperation improves economic benefits and water equality in the Lancang-Mekong River Basin
Authors: Zhang Bingyao , Li Yu , Zhang Chi , Hu Chunhong , Fu Guangtao , Cai Ximing 
Published: March 2022

Abstract
Transboundary river cooperation provides an effective pathway to maintain regional security and sustainable development; however, its implementation is a pressing and prominent concern due to lack of appropriate compensation measures and effective incentive strategies. Here we develop a dual water-electricity cooperation (DWEC) framework that combines water and electricity trading to meet the often-conflicting demands of participating countries. The results from the Lancang-Mekong River Basin reveal that substantial benefits in both economic and social aspects can be achieved through coupling regional water and electricity trades. Economic benefits can be obtained by expanding cooperation space and thereby greatly improving the willingness of countries to participate in basin-wide cooperation. Electricity trading plays a key role in loss compensation for water exporters, ensuring no loss for any party and maximizing basin-wide benefits. Furthermore, the DWEC improves regional water use equality, especially in water shortage periods when there is severe competition among water users. The proposed cooperation framework provides a viable way to implement cooperation in transboundary river basins.
Regulation of Adropin by Sitagliptin Monotherapy in Participants With Newly Diagnosed Type 2 Diabetes
Authors: Wang Qiu , An Yu , Zhang Lin , Zhang Yuanying , Wang Guang , Liu Jia 
Published: March 2022

Abstract
Background: Adropin is a potent metabolic regulator of insulin sensitivity and glycolipid metabolism. The present study investigated the effects of sitagliptin on adropin and metabolic parameters in participants with newly diagnosed type 2 diabetes (T2D).Methods: Thirty-five participants were diagnosed with T2D and were prescribed sitagliptin 100 mg once daily for 17 weeks. Twenty-eight age-, sex-, and BMI-matched healthy subjects were included as the control group. Adropin and clinical parameters were assessed at baseline and after treatment.Results: Serum adropin levels were lower in T2D participants than in the healthy individuals (3.12 ± 0.73 vs. 5.90 ± 1.22 ng/ml, P < 0.01). Serum adropin levels were significantly increased in T2D patient after sitagliptin treatment (4.97 ± 1.01 vs. 3.12 ± 0.73 ng/ml, P < 0.01). The changes in serum adropin levels after sitagliptin treatment were parallel with the improving of fasting blood glucose (FBG) (β = -0.71, P < 0.01), glycosylated hemoglobin (HbA1c) (β = -0.44, P < 0.01) and homeostatic model assessment of β-cell function (HOMA-β) (β = 9.02, P < 0.01).Conclusions: Sitagliptin treatment significantly increased serum adropin levels in participants with newly diagnosed T2D. And the changes in serum adropin levels were parallel with the amelioration of glucose metabolism. Trial registration: Clinicaltrials.gov, NCT04495881. Retrospectively registered on 3 August 2020.
Influence of emotionally affective imaginations on the Adaptive Force in young woman: unpleasant imaginations reduce the holding capacity of muscles
Authors: Schaefer Laura V , Dech Silas , Wolff Lara L , Bittmann Frank N 
Published: March 2022

Abstract
Emotionally affective imaginations can influence the Adaptive Force (AF) in healthy participants as was recently shown in an exploratory study. The AF describes the neuromuscular holding capacity in reaction to an increasing external force, which was suggested to be especially vulnerable for interfering inputs. The present study investigated the influence of pleasant and unpleasant food imaginations on the manually assessed AF of elbow and hip flexors objectified by a handheld device in 12 healthy participants in an improved design. Baseline measurements, randomization of imagination tasks and single-blinding were implemented. The maximal isometric Adaptive Force (AFisomax) was significantly reduced during unpleasant vs. pleasant imaginations and baseline (p < 0.001, dz = 0.98 to 1.61). During unpleasant imaginations muscle lengthening started at 59.00 ± 22.50% of the maximal AF, which was reached during eccentric muscle action. For baseline measurements and pleasant imaginations, this ratio amounted ~97.90 ± 5.00% for both muscles, indicating that the participant was able to maintain the isometric position during the entire external force increase. For those stable adaptations, oscillations arose in force signal at a level of ~72.26 ± 12.89% of AFmax, whereby they occurred under isometric conditions. For unpleasant imaginations, the onset of oscillation was at a force of 84.28 ± 14.03% of AFmax, which in most cases was after the muscle started to lengthen.In conclusion, healthy participants showed an impaired holding function triggered by unpleasant imaginations, which are assumed to be related to negative emotions. This muscular instability is suggested to lead to joint destabilization which can result in musculoskeletal complaints. Therefore, the findings might support the understanding of the causal chain of linked musculoskeletal pain and mental stress. A case example (current stress vs. positive imaginations) will be presented, underpinning the hypothesis this approach might support psychomotor diagnostics and therapeutics.
Loss of Starch Synthase IIIa changes starch molecular structure and granule morphology in grains of hexaploid bread wheat
Authors: Fahy Brendan , Gonzalez Oscar , Savva George A. , Warren Frederick J. , Ahn-Jarvis Jennifer H. , Lovegrove Alison , Dunn Jack , Hazard Brittany A. 
Published: March 2022

Abstract
Starch Synthase III plays a key role in starch biosynthesis and is highly expressed in developing wheat grains. To understand the contribution of SSIII to starch and grain properties, we developed wheat ssIIIa mutants in the elite cultivar Cadenza using in silico TILLING in a mutagenized population. SSIIIa protein was undetectable by immunoblot analysis in triple ssIIIa mutants carrying mutations in each homoeologous copy of ssIIIa (A, B and D). Loss of SSIIIa in triple mutants led to significant changes in starch phenotype including smaller A-type granules and altered granule morphology. Starch chain-length distributions of double and triple mutants indicated greater levels of amylose than sibling controls (33.8% of starch in triple mutants, and 29.3% in double mutants vs. 25.5% in sibling controls) and fewer long amylopectin chains. Wholemeal flour of triple mutants had more resistant starch (6.0% vs. 2.9% in sibling controls) and greater levels of non-starch polysaccharides; the grains appeared shrunken and weighed ~11% less than the sibling control which was partially explained by loss in starch content. Despite the elevation in resistant starch, the other effects on starch and grain properties may hamper the usefulness of ssIIIa mutants in breeding applications.
Identification of Function LncRNAs Associated With Hepatocellular Carcinoma
Authors: Wang Xiaolei , Fang Jun , Wang An , Zhu Wuhui 
Published: March 2022

Abstract
Background
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of the digestive tract. New diagnostic and prognostic biomarkers are urgently needed for HCC. To investigate potential pathogenic and prognostic long noncoding RNAs (lncRNAs) associated with HCC, we conduct this study.
Material and Methods
Gene expression matrix were obtained from TCGA and GEO databases. The overlapping differentially expressed genes (DEGs) between TCGA and GEO databases were analyzed using the limma package. Then we constructed mRNA-lncRNA-miRNA network. In the end, Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and survival analysis were performed to find hub lncRNAs related to diagnosis and prognosis of HCC.
Results
In total, 299 DEGs including 10 lncRNAs and 289 mRNAs were acquired. The mRNA-lncRNA-miRNA network comprised of four lncRNAs (GSEC, LINC00844, LINC01146 and MIR99AHG), 49 miRNAs and 25 mRNAs. GO and KEGG analysis shown that four lncRNAs were mainly enriched in cell cycle. In addition, survival analysis demonstrated that there is a significant correlation between GSEC and overall survival rate. Finally, the expression of LINC00844, LINC01146 and MIR99AHG were down-regulated in HCC tissues, and GSEC was up-regulated.
Conclusion
In summary, four lncRNAs including GSEC, LINC00844, LINC01146 and MIR99AHG may play an important part in the development of HCC. The function of these lncRNAs may have a great effect to the overall survival rate of HCC.
Serious Environmental Threat Water Hyacinth (Eichhornia crassipes) Plant Natural Fibers: Different Extraction Methods and Morphological Properties for Polymer Composite Applications
Authors: Thangiah Winowlin Jappes Jebas , Arivendan Ajithram , Basha Adamkhan Mahaoob , Nagarajan Rajini , Daphne Reena 
Published: March 2022

Abstract
The aim of this research is to explore the different types of water hyacinth plant fiber extraction methods, as well as the effects of several extraction methods to obtain appropriate hyacinth fibers. During this research, we first tried several extraction methods, such as the conventional retting process, manual extraction method, hot water extraction method, and chemical hot water boiling method. Nevertheless, in all cases, the fiber quantity produced by this method is very low, while the quality of the fiber surface is harmed. An automated machine with the help of a bare motor is then used to perform the extraction process through mechanical means. The goal of the hyacinth fiber production process is to produce a much higher quantity of good-quality fiber. Only mechanical extraction is capable of accomplishing this goal. A mechanically extracted fiber has a cellulosic content of 65 to 68%, and a hemicellulose content of 35%, as well as a lignin content of 2.56% and moisture content of 0.215%. Water hyacinth fibers measure 45 to 65 cm long, 150 mm wide, and have a density of 1.226 grams per cubic centimeter. Specifically, the results showed that the fiber surface conditions had an impact on the optimum length of the hyacinth fiber.
Clinical Efficacy and Diagnostic Value of Metagenomic Next- Generation Sequencing for Rapid Pathogen Detection in Patients with Suspected Infectious Diseases
Authors: Xiao Yang-hua , Liu Mei-fang , Wu Hong-wen , Xu De-rong , Zhang Wei , Zhao Rui 
Published: March 2022

Abstract
Background
Metagenomic next-generation sequencing (mNGS) is a powerful method for the diagnosis of suspected infections, avoiding empirical broad-spectrum therapy and lessening the risk of drug resistance. However, little is known about its clinical efficacy and diagnostic value when used in routine practice.
Methods
A reference panel of 10 microorganisms was designed to characterize mNGS test accuracy. Retrospective study was performed to compare the diagnostic value of mNGS tests and culture in infectious disease, and evaluated the clinical efficacy of mNGS based on interpretation of mNGS results by clinicians as well as whether leading to a favorable clinical outcome.
Results
At a typical sequencing depth and the concentration of human DNA up to 100,000 cells/ml, the sequencing platform can still detect pathogens at concentration of 400 CFU/ml. Among 518 patients, the sensitivity and specificity of mNGS for diagnosing infectious disease were 79.49% and 82.20%, respectively. The bacteria and fungus detection rate (apart from candida) were significantly higher than culture (P < 0.01). Test sensitivity and specificity of mNGS were 78.40 and 95.27% for bacteria and 75.23 and 93.95% for fungi, respectively. mNGS was especially practical in identification of atypical pathogens, contributing a positive impact in 267(51.54%) cases in which 142 cases where mNGS results directly led to a change in treatment.
Conclusions
mNGS significantly improved sensitivity for bacteria and fungi identification, is a valuable tool for for identifying infectious patients and could optimize antimicrobial therapy to improve the clinical outcomes. Further multicenter and prospective studies with larger samples are needed to validate the clinical efficacy and diagnostic value of mNGS.
Less identifiable but no less helpful: Face masks do not go along with selfish behavior
Authors: Seetahul Yashvin , Greitemeyer Tobias 
Published: March 2022

Abstract
Covering the face with masks in public settings has been recommended since the start of the pandemic. Because faces provide information about identity, and that face masks hide a portion of the face, it is plausible to expect individuals who wear a mask to consider themselves less identifiable. Prior research suggests that perceived identifiability is positively related to prosocial behavior, and with two pre-registered field studies (total N = 5706) we provide a currently relevant and practical test of this relation. Our findings indicate that mask wearers and non-wearers display equivalent levels of helping behavior (Studies 1 and 2), although mask wearers have a lower level of perceived identifiability than those without a mask (Study 2). Overall, our findings suggest that claims that face masks are related to selfish behavior are not warranted, and that there is no practical link between perceived identifiability and prosocial behavior.
The efficacy of XEN gel stent implantation in glaucoma: a systematic review and meta- analysis
Authors: Duan Xuanchu , Yang Xiang , Zhao Yang , Zhong Yu 
Published: March 2022

Abstract
Background Xen45 is a device of minimally invasive glaucoma surgery, which is indicative for refractory glaucoma. The issues of XEN45 in treating glaucoma remains to be confirmed and clarified. Hence, we conducted a systematic review and meta-analysis to examine the efficacy and complication of XEN45 implantations.Methods We conducted a literature search in PubMed, EMBASE, the Cochrane Library of Systematic Reviews, Web of Science, China National Knowledge Infrastructure, WanFang and SinoMed databases to identify studies published before May 15, 2021, that assessed XEN45 in glaucoma, and measurements included intra-ocular pressure (IOP), number of anti-glaucoma medications (NOAM), and bleb needling rate. We compared the measurements of XEN-only procedure between phaco-XEN and trabeculectomy, and we also did sub-analysis according to time points, glaucoma types, ethnics, etc. Sensitivity analyses and publication bias were conducted for evaluating bias.Results We identified 78 eligible studies, analysis revealed obvious IOP reduction after XEN stent implantation (SMD: 1.69, 95% CI 1.52 to 1.86, p value < 0.001) and NOAM reduction(SMD: 2.11, 95% CI 1.84 to 2.38, p value < 0.001). Sub-analysis showed no significant difference according to time points, ethnics, and economic status. No significant difference was found between XEN treatment effect on POAG and PEXG eyes and between pseudo-phakic and phakic eyes. No significant difference was found between XEN and phaco-XEN surgery according to IOP after surgery (SMD: -0.01, 95% CI -0.09 to 0.08, p value 0.894). However, NOAM (after publication bias correction) and bleb needling rate (RR: 1.45, 95% CI 1.06to 1.99, p value 0.019) was lower in phaco-XEN group compared to XEN only group. Compared to trabeculectomy, XEN implantation has similar after-surgery IOP, however bleb needling rate (RR: 2.42, 95% CI 1.33 to 4.43, p value 0.004) was higher.Conclusion Our results confirmed that XEN45 is effective in both lowering IOP and NOAM until 48 months after surgery. It is noteworthy that XEN implantation leads to higher needling rate, compared to phaco-XEN or trabeculectomy. Further studies studying complications of XEN and on non-European ethnics, especially on Asian, are in urgent need before XEN45 is widely applied.
Predicted fundamental niche expansion of Agarophyton vermiculophyllum under present and future climate scenarios
Authors: Mendoza-Segura Clara , Fernández Emilio , Beca-Carretero Pedro 
Published: March 2022

Abstract
The introduction of new species in marine ecosystems is a phenomenon that has grown in recent years due to anthropogenic activities and climate change effects. Agarophyton vermiculophyllum, a red seaweed native from the north-eastern Pacific, has successfully colonised large regions in the Northern Hemisphere; however, there are no studies to date investigating how future climate conditions will affect its potential biogeographical range. In this investigation, we implemented species distribution models (SDMs) based on sea surface temperature (SST) and salinity to determine the potential current, and future distribution of A. vermiculophyllum based on two climate scenarios (Representative Concentration Pathways [RCP 2.6 and RCP 8.5]). The model built for A. vermiculophyllum showed a high discriminatory ability and marked sensitivity. The SDM for present climate settings showed a potential wider distribution than is recorded to date. In addition, a subtle habitat expansion of 2.9º into higher latitudes was reported under the RCP 2.6 scenario by the end of this century. The high carbon emission scenario (RCP 8.5) delivered a potential large habitat expansion (6.0º), even reaching arctic latitudes. Under this climate scenario, it was also observed a remarkable habitat loss of 11° in its southern distribution range. SMDs also forecasted suitable areas for this species in the Southern Hemisphere, pointing toward a potential global expansion in the coming decades. The information reported in this study is relevant to developing management plans to effectively implement contingency actions addressing invasion events, thereby fostering adequate habitat conservation policies.
Shouting strengthens voluntary force during sustained maximal effort through enhancement of motor system state via motor commands
Authors: Takarada Yudai , Nozaki Daichi 
Published: March 2022

Abstract
Previous research indicates that shouting during momentary maximal exertion effort potentiates the maximal voluntary force through the potentiation of motor cortical excitability. However, the muscular force-enhancing effects of shouting on sustained maximal force production remain unclear. We investigated the effect of shouting on the motor system state by examining motor evoked potentials in response to transcranial magnetic stimulation applied over the hand area of the contralateral primary motor cortex (M1) during sustained maximal voluntary contraction, and by assessing handgrip maximal voluntary force. We observed that shouting significantly increased handgrip maximal voluntary force and reduced the silent period. Our results indicate that shouting increased handgrip voluntary force during sustained maximal exertion effort through the reduced silent period. This is the first objective evidence that the muscular force-potentiating effect of shouting during maximal force exertion is associated with the potentiation of motor system activity produced by the additional drive of shouting operating on the motor system (i.e., shouting-induced excitatory input to M1).
Implant Migration and Functional Outcome of Reverse Shoulder Lateralized Glenosphere Line Extension System: A Study Protocol for a Randomized Controlled Trial
Authors: Jensen Marie Louise , Olsen Bo Sanderhoff , Nyring Marc Randall Kristensen , Yilmaz Müjgan , Petersen Michael Mørk , Flivik Gunnar , Rasmussen Jeppe Vejlgaard 
Published: March 2022

Abstract
Background Inferior scapular notching is a complication unique to reverse shoulder arthroplasty. The most efficient technique to avoid inferior scapular notching has been reported to be lateralization of the glenoid offset. This study aims to compare radiological and functional outcomes of the DELTA Xtend® Reverse Shoulder System Lateralized Glenosphere Line Extension (intervention group) with the Standard DELTA Xtend® Reverse Shoulder System (control group).MethodsIn this randomized controlled trial, all Danish citizens with rotator cuff arthropathy or degeneration of the glenohumeral joint with severe posterior wear and allocated for a reverse total shoulder arthroplasty at the department of orthopaedic surgery at Herlev and Gentofte Hospital, Copenhagen University Hospital will be considered for participation. The exclusion criteria are: Below 50 years of age; Cognitive or linguistic impairment; Insufficient glenoid bone stock; Previous fracture in the upper extremity; Autoimmune mediated inflammatory arthritis. There will be included a total of 122 patients of which 56 will participate in the radiostereometric analysis. This number of patients allows 20% to drop out. The primary outcome is the pattern and magnitude of the migration of the glenoid component and functional outcome (WOOS score). The secondary outcomes are the position of the arthroplasty, loosening, inferior scapular notching, patient-reported and functional outcomes (Oxford shoulder score, Constant Murley score and pain), number of complications, readmissions, revision, changes in bone mineral density and economy. The migration is assessed by radiostereometric analysis and the bone mineral density. The included patients will be examined before the surgery, within 1 week and 3, 6, 12 and 24 months after.DiscussionNo previous studies have compared the conventional reverse shoulder arthroplasty with the lateralized reverse shoulder arthroplasty in a randomized controlled trial regarding functional, radiographic and patient-reported outcomes. Furthermore, radiostereometric analysis has not been used to evaluate the migration of reverse shoulder arthroplasty. This study intends to determine which treatment is best for the benefit of future patients with an indication for reverse shoulder arthroplasty.Trial registrationThe study has been notified to Pactius and has approval number P-2021-231. Furthermore, the study will be registered on clinicaltrials.gov before start inclusion.