bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing and addressing COVID-19 vaccine hesitancy in a West Texas Free Clinic through motivational interview-guided intervention
Authors: Nesiama Esere , Vopni Rachel , Fuentes Nayeli , Prabhu Fiona , Bennett Kelly 
Published: October 2022

Background
Vaccine hesitancy is a public health issue that threatens successful prevention of vaccine-preventable diseases. The Free Clinic at Lubbock Impact serves rural, West Texas uninsured patients. In recognition of low vaccination rates among this population, an initiative was undertaken to better understand factors contributing to COVID-19 vaccine reluctance and conduct interventions to reduce hesitancy.
Methodology
Patients at the Free Clinic between January 2022 and March 2022 received a voluntary survey regarding their COVID-19 vaccination status, perceived barriers to vaccination, and factors influencing vaccination status with Likert-scale response options. Following the first 3 weeks of data collection, an educational intervention was designed and implemented for unvaccinated participants. The intervention included a motivational interview, pamphlet review, and exit survey to assess future likelihood of vaccination.
Results

A total of 161 survey responses were obtained from the initial survey with a total unique patient population of 138. Of the 138 unique patients surveyed, 73 reported as vaccinated and 65 reported as not vaccinated against COVID-19. For hesitancy factors among unvaccinated participants, the mode for the “Extremely Important” hesitancy factor was “Personal Preference”.

37 of the 41 unvaccinated participants who received an intervention reported liking the discussion of the COVID-19 vaccine (90.2%), 4 reported they were not interested (9.8%), and 0 reported disliking the intervention. Half of the respondents indicated an increased likelihood of future vaccination.

Conclusion
The goal of reducing vaccine hesitancy at The Free Clinic was successful. These findings support the benefits of openness to educational interventions among vulnerable populations.
Progressive lower extremity weakness as the initial presentation of isolated large thoracic plasmacytoma
Authors: Abdelnabi Mahmoud , Morataya Cristina , Mittal Neha 
Published: October 2022

Plasmacytoma is a tumor of monoclonal plasma cells of bone or soft tissue that can occur anywhere in the body without evidence of systemic multiple myeloma. It may present as solitary or multiple masses and is classified as osseous if arising from bone or extraosseous if arising from soft tissue. Osseous plasmacytoma is the most common form of plasmacytoma with predominance in active hematopoietic bones, including vertebrae, femur, pelvis, and ribs. The diagnosis is made with a tissue biopsy. Different imaging modalities allow for tumor localization, and magnetic resonance imaging (MRI) is the gold standard to detect spinal cord compression. Corticosteroids provide analgesia, reduce vasogenic edema, and have anti-myeloma activity which may result in better neurological outcomes in cases of acute spinal cord compression. Corticosteroids should be started promptly once cord compression is suspected. We report a case of progressive lower extremity weakness as the initial presentation of a thoracic plasmacytoma. The patient was started on a high-dose corticosteroid after acute cord compression was suspected. Magnetic resonance imaging confirmed cord compression. T1-T2 corpectomy with C5-T5 posterior spinal fusion for decompression and stabilization was done. He was successfully discharged to an inpatient rehabilitation facility with plans for definitive radiotherapy. Worsening back pain and lower extremity weakness in elderly patients should raise concerns for acute cord compression. Early intervention to relieve compression is crucial to preserve neurological functions.

Keywords: plasmacytoma, weakness, steroids, multiple myeloma
Pain problem in patients in palliative home care
Authors: Czernecki Karol , Ślusarska Barbara 
Published: October 2022

Aim of the study: The aim of the study is to determine the intensity and nature of pain and treatment methods, as well as to assess the patient's sense of comfort in palliative care in the home environment.

Material and methods: Research using the diagnostic survey method, using the PAPI (Paper & Pen Personal Interview) technique, was carried out among patients in palliative care provided by the home care team in March and April 2022. The study included 55 palliative patients under the care of the home palliative care team in the following cities: Warszawa, Kraków, Sosnowiec and the poviats of Stalowa Wola, Tarnobrzeg and Sandomierz.
Results: Of the 55 patients studied, the majority of 50.9% (n = 28) were men. The vast majority of 90.9% (n = 50) of people replied that pain was present, but patients were taking pain medications. Pain in the majority of patients, 65.5% (n = 36), it was felt at any time during the day. On the NRS scale, pain intensity ranging from 4 to 7 points was assessed by 61.8% of patients. Among the symptoms associated with pain, patients indicated the following as very severe: fatigue and weariness (63.6%), drowsiness (41.8%), nervousness (40.0%), depression (38.2%), difficulty concentrating (32.7%), lack of energy, weakness (30.9%), worry (36.4%), apathy (36.4%), dry mouth (34.5%). The average result on the comfort scale in the group of patients is M = 34.50; SD = 5.04. There was a statistically significant correlation between satisfaction with care and the level of perceived comfort (p = 0.014).
Conclusions: In the group of palliative patients treated at home, "pain" is one of their main ailments. Most patients take painkillers to reduce or completely eliminate the pain. However, the symptoms associated with it remain. Patients who strongly indicated satisfaction with care had a significantly higher level of comfort compared to other patients
Virtualización de una muestra de la colección de modelos dermatológicos de cera del Museo Olavide
Authors: Hernández-Muñoz Óscar , Aranda Gabrielli David , Maruri Palacín Amaya , Sterp Moga Emanuel , Sánchez-Ortiz Alicia 
Published: October 2022

El Museo Olavide de Madrid posee una importante colección de modelos dermatológicos didácticos creados en cera de abejas policromada durante los siglos xix y xx como material de apoyo para la formación de los médicos en las enfermedades de la piel. En este artículo se describe la historia del museo y de su fundador, el doctor Eugenio Olavide, así como la técnica empleada por los diferentes ceroescultores que trabajaron en él. Además, se muestra el trabajo de virtualización realizado recientemente sobre una muestra significativa de la colección merced a la colaboración entre los conservadores del museo y el grupo de investigación de la Universidad Complutense de Madrid Arte, Tecnología, Imagen y Conservación del Patrimonio Cultural. La metodología empleada constó de una primera etapa en la que se digitalizaron las obras mediante fotogrametría y escáner de luz estructurada, y de una segunda, en la que se optimizaron para su publicación en Sketchfab.com. Como resultado, se obtuvo una serie de modelos tridimensionales de alta definición que están accesibles para su estudio desde Internet. En este estudio se ha comprobado que las plataformas de visualización de archivos 3D permiten compartir información precisa sobre modelos dermatológicos didácticos para su estudio y difusión.
Applications of machine learning tools for ultra-sensitive detection of lipoarabinomannan with plasmonic grating biosensors in clinical samples of tuberculosis
Authors: Huang Yilun , Darr Charles M. , Gangopadhyay Keshab , Gangopadhyay Shubhra , Bok Sangho , Chakraborty Sounak 
Published: October 2022

BackgroundTuberculosis is one of the top ten causes of death globally and the leading cause of death from a single infectious agent. Eradicating the Tuberculosis epidemic by 2030 is one of the top United Nations Sustainable Development Goals. Early diagnosis is essential to achieving this goal because it improves individual prognosis and reduces transmission rates of asymptomatic infected. We aim to support this goal by developing rapid and sensitive diagnostics using machine learning algorithms to minimize the need for expert intervention.Methods and findingsA single molecule fluorescence immunosorbent assay was used to detect Tuberculosis biomarker lipoarabinomannan from a set of twenty clinical patient samples and a control set of spiked human urine. Tuberculosis status was separately confirmed by GeneXpert MTB/RIF and cell culture. Two machine learning algorithms, an automatic and a semiautomatic model, were developed and trained by the calibrated lipoarabinomannan titration assay data and then tested against the ground truth patient data. The semiautomatic model differed from the automatic model by an expert review step in the former, which calibrated the lower threshold to determine single molecules from background noise. The semiautomatic model was found to provide 88.89% clinical sensitivity, while the automatic model resulted in 77.78% clinical sensitivity.ConclusionsThe semiautomatic model outperformed the automatic model in clinical sensitivity as a result of the expert intervention applied during calibration and both models vastly outperformed manual expert counting in terms of time-to-detection and completion of analysis. Meanwhile, the clinical sensitivity of the automatic model could be improved significantly with a larger training dataset. In short, semiautomatic, and automatic Gaussian Mixture Models have a place in supporting rapid detection of Tuberculosis in resource-limited settings without sacrificing clinical sensitivity.
The role of NPM1 alternative splicing in patients with chronic lymphocytic leukemia
Authors: Szelest Monika , Masternak Marta , Zając Małgorzata , Chojnacki Michał , Skórka Katarzyna , Zaleska Joanna , Karczmarczyk Agnieszka , Stasiak Grażyna , Wawrzyniak Ewa , Kotkowska Aleksandra , Siemieniuk-Ryś Monika , Purkot Joanna , Subocz Edyta , Cichocka Edyta , Tomczak Waldemar , Zawirska Daria , Giannopoulos Krzysztof 
Published: October 2022

Objectives
Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disease with heterogeneous clinical course. Recent studies revealed a link between NOTCH1 mutation and the overexpression of MYC and MYC-related genes involved in ribosome biogenesis and protein biosynthesis, such as nucleophosmin-1 (NPM1), in CLL cells. In the present study, we aim to evaluate the impact of the NOTCH1 mutation on the MYC and MYC induced NPM1 expression in CLL cells via quantification of their transcripts.

Methods
Using qRT-PCR, we analyzed the levels of MYC and three main NPM1 splice variants in 214 samples collected from CLL patients. We assessed the impact of each splice variant on CLL prognostic markers, including the IGHV, TP53, NOTCH1, SF3B1, and MYD88 mutational status, cytogenetic aberrations, and laboratory features.

Results
Significantly higher levels of NPM1.R1 transcripts in patients with unmutated compared to mutated IGHV status were found. The median time to first treatment (TTFT) in patients with a high level of NPM1.R1 was significantly shorter compared to the group with low NPM1.R1 levels (1.5 vs 33 months, p = 0.0002). Moreover, in Multivariate Cox Proportional Hazard Regression Model NPM1.R1 splice variant provided an independent prognostic value for TTFT.

Conclusion
In conclusion, our study indicates the prognostic significance of the level of NPM1.R1 expression and suggests the importance of splicing alterations in the pathogenesis of CLL.
Penguatan Industri Kreatif Batik Semarang di Kampung Alam Malon Kecamatan Gunung Pati Semarang
Authors: Suliyati Titiek 
Published: October 2022

Penelitian ini mengkaji tentang Penguatan Industri Kreatif Batik Semarang di Kampung Alam Malon Kecamatan Gunung Pati Semarang. Akibat perkembangan industri batik di Semarang, mengakibatkan munculnya sentra batik di berbagai wilayah, salah satunya adalah Kampung Alam Malon. Permasalah penelitian yang akan dikaji adalah bagaimana masyarakat Kampung Alam Malon yang semula tidak memiliki ketrampilan membatik dapat didorong menjadi perajin batik dan mendorong kampungnya memperoleh kemajuan sebagai Kampung Tematik dan kampung Wisata. Metode yang digunakan adalah metode kualitatif deskriptif. Penelusuran data dilakukan melalui survey, studi pustaka dan wawancara mendalam. Pendekatan historis digunakan untuk mencari korelasi sumber-sumber. Fakta-fakta sejarah yang dihasilkan kemudian dianalisis melalui pendekatan budaya dan disusun secara deskriptif. Hasil bahasan adalah bahwa, batik yang diproduksi di Kampung Alam Malon memiliki ciri khas yang berbeda dengan batik dari daerah lain. Ciri khas batik Kampung Alam Malon adalah batik dengan pewarna alami. Industiri batik ini telah menyebabkan perubahan masyarakat, yaitu masyarakat dapat meningkatkan kesejahtraannya. Kesimpulan mengungkapkan bahwa industri batik telah mendorong Kampung Alam Malon memperoleh predikat Kampung Tematik dan Kampung wisata. Kemajuan kampung ini di dukung oleh modal sosial masyarakat yang tinggi dan potensi-potensi lain yang bisa dikembangkan.
Konstruksi Verba Serial Tipe Gerakan Direksional Pada Bahasa Palembang Kajian Tipologi
Authors: Maghfiroh Hanif , Subiyanto Agus 
Published: October 2022

Bahasa Palembang merupakan salah satu bahasa di Nusantara yang termasuk dalam rumpun Austronesia. Meskipun sama-sama berasal dari rumun Autronesia bahasa Palembang memiliki KVS yang berbeda dengan bahasa Palembang.Tujuan dari penelitian ini yaitu untuk mengetahui konstrusi verba serial bahasa Palembang tipe gerak direksional dan tipenya dalam tipologi talmy yang kemudian dilihat perebdaannya dengan bahasa Jawa. Sumber data yang digunakan berupa bahasa Palembang sehari-hari dari penutur asli, serta bahasa Jawa dari intiusi penulis. Metode pengumpulan data yang digunakan yaitu wawancara dan studi pustaka, sedangkan teknik pengumpulan data yang digunakan berupa teknik simak dan catat. Teknik analisis data menggunakan pendekatan tipologi. Hasil peneliltian ini membuktikan bahwa KVSBPTGD dapat dibentuk dengan pola V1 transitif + V2 transitif dan V1 intransitif+V2 intransitif. Berdasarkan tipologi Talmy bahasa Palembang dan bahasa Jawa sama-sama dapat digolongkan ke dalam bahasa berkerangka verba maupun satelit, namun jika diujikan menggunakan alat ukur berupa kepemilikan pola resultif ajektif, bahasa Palembang termasuk ke dalam bahasa berkerangka satelit tidak seperti bahasa Jawa yang berkerangka verba.)
Kerangka Dasar Kepustakawanan Indonesia: Redefinisi Kepustakawanan Indonesia
Authors: Christiani Lydia 
Published: October 2022

Penelitian ini bertujuan untuk menelisik lebih lanjut tentang konsepsi Kerangka Dasar Kepustakawanan Indonesia yang digagas oleh Blasius Sudarsono. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kualitatif. Hasil penelitian ini menunjukkan bahwa Kerangka Dasar Kepustakawanan Indonesia (KDKI) merupakan sebuah panduan berkarya ideal bagi pustakawan Indonesia. KDKI menunjukkan posisi kepustakawanan sebagai daya tumbuh pribadi pustakawan sekaligus sebagai wujud puncak pertumbuhan pribadi pustakawan. KDKI merumuskan poin utama empat pilar penyangga kepustakawanan Indonesia yaitu panggilan hidup, semangat hidup, karya pelayanan, dan profesionalisme, yang dilandasi oleh lima kemampuan dasar, yaitu kemampuan berpikir, menulis, membaca, kemampuan wirausaha, dan menjunjung tinggi etika. Kemudian menuju tiga sasaran antara yaitu menjadi pustakawan cerdas, kaya dan benar guna mencapai satu tujuan akhir yaitu pribadi pustakawan yang memiliki kepribadian kepustakawanan Indonesia yang diilhami konsep pribadi pustakawan sebagai manusia paripurna, bahagia dan berguna bagi sesama. KDKI menekankan pada sisi humanistik pada profesi pustakawan, hal tersebut dapat ditengarai pada tiap poin KDKI yang selalu menempatkan pustakawan sebagai subjek utamanya. KDKI juga ditujukan sebagai pemicu diskursus tentang kepustakawanan Indonesia, yang diharapkan dapat memunculkan pemikiran-pemikiran lebih lanjut tentang kepustakawanan Indonesia.
Intra-species variation in maximum moisture content, cell-wall density and porosity of hardwoods
Authors: Riesco Muñoz Guillermo , Pulgar Lorenzo José Ángel 
Published: October 2022

Abstract
Some properties of wood, such as maximum moisture content, cell-wall density and porosity, are not well known, even though they affect the performance of chemical preservatives, glues and coatings on wood. This knowledge gap was addressed in the present study by analysing these physical properties in laurel (Laurus nobilis L.) wood. Laurel is a common hardwood tree in southern Europe. Seventeen laurel trees were felled for the study, and 300 defect-free specimens were obtained from the trees for analysis. The following mean values were obtained: wood maximum moisture content, 114%; cell-wall oven-dry density, 1198 kg m−3; and oven-dry wood porosity, 45%. Significant inter- and intra-tree variations in the three properties were observed. The inter-tree variation was mainly attributed to the tree age, and the trend suggests that wood maximum moisture content and porosity are expected to be lower in older trees than those under study. The values of the three properties were slightly, but statistically significantly, lower at the highest positions in the tree. Harvesting of the basal logs of young trees is therefore advisable only if more porous wood is required, and commercial exploitation of the whole trunk of mature trees is recommended if more compact wood is required. The variation in cell-wall density was not negligible, although this variable is often assumed to be approximately constant for all wood species. Maximum moisture content and wood porosity can be estimated using bulk or apparent density as a predictor variable.
Sustainability Value – Ökologie und Ökonomie auf einen Blick
Authors: Kurek Rainer , Chennoju Sai 
Published: October 2022

Abstract
Klima- und Energiewende, Umwelt- und Ressourcenschonung gehören zu den zentralen Herausforderungen unserer Zeit. Nachhaltigkeit gewinnt an Bedeutung. Um der „Corporate Social Responsibility“ gerecht werden zu können, ist es nötig, Produkte für den Markt vorzusehen, die ein positives Ökologie- und Ökonomie-Verhältnis ermöglichen. Die Sustainability-Value-Analyse ist ein Management-Instrument, das genau diesen Zweck erfüllt, wie am Beispiel einer „NFK in 3D“-Tragstruktur der NAchhaltigen MIttel-KOnsole „NAMIKO“ dargestellt wird: Nachhaltigkeit im „Frontloading“.
Characteristics of germinated corn flour and influence of germination on cookie properties
Authors: Oskaybaş-Emlek B. , Özbey A. , Kahraman K. 
Published: October 2022

AbstractThe aim of this study was to investigate the effect of germination on the physicochemical, structure, pasting, and morphological properties of corn. Germination improved total phenolic content (TPC) and antioxidant capacity (AC). Scanning electron micrographs (SEM) of flour showed that some starch granule was destroyed with germination. In the same way, pasting values decreased due to changes in the starch granule. FT-IR (Fourier Transform Infrared) spectra confirmed that germination leads to changes in the chemical structure. The XRD (X-ray diffractometer) analysis showed that patterns did not change with germination. In addition, raw and germinated corn flour were used in gluten-free cookie preparation. The cookie dough was evaluated for stickiness. The physical, textural, colour, TPC, and AC of cookie samples were determined. Gluten-free cookies prepared with germinated flour exhibited significantly higher AC due to increase in TPC. Germination could be used to enhance functional properties of corn.
NUMERICAL SIMULATION OF DYNAMIC MECHANICAL PROPERTIES OF GRAPHENE-REINFORCED ALUMINUM MATRIX COMPOSITES
Authors: Du Xiaoming , Lu Zhixuan , Guo Shuang 
Published: October 2022

The effects of the strain rate of dynamic loading, volume fraction, shapes and orientation of graphene on the dynamic mechanical properties, deformation and damage of graphene/7075Al composites were simulated using the finite element method, and the damage mechanism of the composites under dynamic load was revealed. The flow strain-stress curves were obtained. The effect of strain rates on the flow stress of the composites was analyzed. The results show that graphene/7075Al composites exhibit a significant strain rate effect. With an increase in the volume fraction of graphene, the yield strength of the composites increases and the composites have significant stress-softening characteristics at a strain rate of 10000 s–1, leading to a reduced strain-hardening effect. The shape and orientation of graphene have an important influence on the dynamic mechanical properties and the extent of damage made to the composites. The flow stress of the composites increases with varying the graphene shape and orientation in the following order, respectively: prism < cylinder < platelet < disc and 0°< 3D < 90° < 45°. The extent of the damage to the composites increases in the following order: disc < platelet < cylinder < prism and 0° < 3D < 90° < 45°. The dynamic failure mechanism of graphene/7075Al composites is interface damage.
Amorphous Iron Phosphate: Inorganic Sol-Gel Synthesis-Sodium and Potassium Insertion
Authors: Maarouf Fatima-Ezzahra , Saoiabi Sanaa , Azzaoui Khalil , Khalil Hind , Khalil Mariam , Yahyaoui Ahmed El , Saoiabi Ahmed , Hammouti Belkheir , Youssoufi Moulay Hfid , Shityakov Sergey , Hamed Othman , Jodeh Shehdeh , Sabbahi Rachid 
Published: October 2022

Amorphous iron phosphate, FePO4.2H2O, was synthesized at ambient temperature using an inorganic sol-gel method coupled with a microwave route. The experimental conditions for the gelling of the Fe (III)-H3PO4 system are defined. Potentiometric Time Titration (PTT) and Potentiometric Mass Titration (PMT) methods were used to investigate the acid-base surface chemistry of obtained phosphate. Variations of surface charge with the contact time, Q = f(t), are examined for time contact ranged from 0 to 72 hours. The concentrations suspensions used for this purpose were 0.75, 1.25, and 2.5 g/L. The point of zero charges (PZC) and isoelectric point (IEP) were defined using the derivative method examining the variations , at lower contact time. A value of 5.4 was obtained for both PZC and IEP. Q in the function of the t method is performed for synthesized FePO4. 2H2O in NaCl and KCl electrolytes. The optimal surface charge of 40 C corresponding to insertion of 4.2x10-4 M of Na+ or K+, is achieved in explored conditions. The results suggest that the synthesized iron phosphate is amorphous.