bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of lipid metabolism disorders with the development of fatal and non-fatal cardiovascular events in residents of the Chui region of the Kyrgyz Republic of varying sex and ethnicity
Authors: Polupanov A. G. , Mamatov A. U. , Kontsevaya A. V. , Duishenalieva M. T. , Khalmatov A. N. , Bebezov I. Kh. , Akhunbaev S. M. , Sabirov I. S. , Dzhumagulova A. S. 
Published: March 2022

Aim. To study the relationship of lipid metabolism disorders (overweight, general and abdominal obesity (AO)) with the development of fatal and non-fatal cardiovascular events (CVEs) among residents of the Chui region of the Kyrgyz Republic of varying sex and ethnicity.Material and methods. This study was performed as part of the international prospective epidemiological project “Interepid”. The total follow-up period was 7 years. Vital status at the end of the follow-up period was monitored in 1096 respondents from 1341 initial cohorts. Response rate was 82,1%. As an endpoint, the analysis included cases of fatal and non-fatal CVEs. The prevalence of events was assessed by survival analysis methods (Cox proportional hazard regression model, parametric survival models, Kaplan-Meier estimator).Results. In total, 181 (16,44%) cases of fatal and non-fatal CVEs were recorded during the follow-up period. In individuals with normal body weight, the incidence of CVEs was 10%. In overweight persons, it increased and reached 17,99% (p<0,001), while in those with obesity — 24,5% (p<0.0001). An increase in CVE rate with an increase in body mass index was recorded in all analyzed subgroups (men, women, Russians, Kyrgyz). Cox regression model with a logistic regression analysis made it possible to confirm the independent role of general and AO in the development of fatal and non-fatal cardiac and cerebral accidents in both ethnic groups in women, but not in men.Conclusion. An increase in body mass index >25 kg/m2 and the presence of AO are independent risk factors for fatal and non-fatal CVEs in the analyzed cohort of residents of the Chui region in women (but not men) of both ethnic groups.
Inflammatory continuum in the pathogenesis of atrial fibrillation after coronary bypass surgery
Authors: Mingalimova A. R. , Drapkina O. M. , Sagirov M. A. , Mazanov M. Kh. , Bikbova M. M. , Argir I. A. 
Published: March 2022

Atrial fibrillation (AF) after coronary bypass surgery is recorded in 20- 60% of patients and increase the early and long-term postoperative mortality. The aim of the review is to analyze the studies on causal relationships between damaging factors and the development of myocardial inflammation at each stage of surgical treatment in patients with multivessel coronary artery disease. In the review, myocardial inflammation is considered from the point of view of a continuum — a chronic process that originates from the coronary endothelium damage and continuously proceeds within the AF pathogenesis after coronary bypass surgery. For the first time, the concept of inflammatory continuum for postoperative AF is introduced. The review discusses the main and latest laboratory and instrumental markers of local and systemic inflammatory response, which are informative in terms of severity and promising for improving approaches to the diagnosis and prevention of postoperative AF. The review was prepared using available materials from Russian and foreign library databases (PubMed, Medline, Web of Science and Cochrane Library). The search depth was >25 years since 1996. Based on the analysis of available studies, we concluded that inflammation is not just evidence of AF, but plays a causal role in its pathogenesis at each stage of surgical myocardial revascularization.
NEWS2, 4C Mortality Score, COVID-GRAM, Sequential Organ Failure Assessment Quick scales as outcomes assessment tools for severe COVID-19 (pilot retrospective cohort study)
Authors: Vechorko V. I. , Averkov O. V. , Grishin D. V. , Zimin A. A. 
Published: March 2022

Aim. To study the predictive ability of the NEWS2, 4C Mortality Score, COVID-GRAM and qSOFA scales in predicting clinical outcomes in patients with severe coronavirus disease 2019 (COVID-19) hospitalized in a multidisciplinary hospital.Material and methods. The pilot retrospective cohort study used data from 90 patients (52 — intensive care unit subgroup, 38 — general unit subgroup) with a confirmed diagnosis of COVID-19 hospitalized in the O.M. Filatov City Clinical Hospital № 15 (Moscow) from January to March 2021.Results. The probability of a positive outcome of the disease significantly negatively correlates with the patient’s age (R=-0,514; p=0,0002). The best correlation with the COVID-19 outcome had a 4C Mortality Score (R=0,836; p=0,0001). Logistic regression revealed a significant dependence of the “outcome” and “age” parameters with the greatest accuracy in the form of age subgroups according to the World Health Organization classification with odds ratio (OR) of 4,29 (p=0,0001). As a result of ROC analysis, the best predictive ability of disease outcomes was shown for the 4C Mortality Score (area under curve (AUC)=0,878; 95% confidence interval (CI): 0,782- 0,975 (p=0,00001)) and COVID-GRAM (AUC=0,807; 95% CI: 0,720- 0,895 (p=0,00001)); taking into account the division of patients into age subgroups, optimal predictive tools were obtained: in subgroups 18-44 years old and 45-59 years old — the 4С Mortality Score (AUC=0,892, 95% CI: 0,762-0,980 (p=0,002) and AUC=0,853, 95% CI: 0,784-0,961 (p=0,0014), respectively); in the subgroup 60-74 years old — the COVID-GRAM (AUC=0,833, 95% CI: 0,682-0,990 (p=0,038)); in subgroups 75-90 years and >90 years — NEWS2 (AUC=0,958, 95% CI: 0,807-1,0 (p=0,002) and AUC=0,818, 95% CI: 0,713-0,996 (p=0,006), respectively). ROC analysis showed that the age of 70 years is the threshold value, above which the probability of an unfavorable COVID-19 outcome increases significantly (OR=11,63; 95% CI: 9,72- 12,06 (p=0,0052)).Conclusion. The pilot study showed the significance of predicting the hospitalization outcome of patients with severe COVID-19. The 4C Mortality Score and COVID-GRAM scales had the best predictive accuracy. The specificity and sensitivity of the scores depended on the age of a patient. The age of 70 years was the threshold value at which the risk of an adverse outcome increased significantly. Based on the data obtained, it is planned to study the problem of predicting the disease course, taking into account the severity of COVID-19.
Development, validation and assessment of reproducibility of a modern version of semi-quantitative food frequency questionnaire for the adult population
Authors: Karamnova N. S. , Maksimov S. A. , Shalnova S. A. , Shvabskaia O. B. , Izmailova O. V. , Ivanova E. I. , Molchanova O. V. , Kontsevaya A. V. , Drapkina O. M. 
Published: March 2022

The changing structure of food consumption requires updating the nutrition assessment tool, taking into account modern dietary patterns.Aim. To develop, evaluate the validity and reproducibility of semiquantitative food frequency questionnaire (FFQ) for the adult population.Material and methods. The FFQ questionnaire was developed as part of the Russian part of the international Prospective Urban and Rural Epidemiological (PURE) study. To compare the quantitative parameters of the energy and nutritional value of diet, the validation used data on the actual nutrition of 294 men and women aged 25-65 years, collected by 2 methods: 24-hour dietary recall (24hDR) — 4 surveys per year (1 time per season) and the developed FFQ — 2 surveys: initially (FFQ1) and after 12 months (FFQ2).Results. The minimum mean values for the vast majority of nutrients were recorded by the 24hDR method, while higher values — by FFQ2, and maximum values — by FFQ1. Pearson’s correlation coefficients ranged from 0,19 (retinol equivalent) to 0,53 (cholesterol), showing a moderate relationship between the two methods. After crossclassification, the proportion of subjects assigned to the same quartile of 24hDR and FFQ2 nutrient profile ranged from 26,9% (β-carotene) to 43,5% (cholesterol), and those assigned to opposite quartiles ranged from 3,1% (cholesterol) to 11,2% (retinol equivalent), indicating good agreement between these methods. The Bland-Altman plots showed slightly overestimated FFQ2 scores for total carbohydrate, protein, and dietary calories. The Pearson correlation between FFQ1 and FFQ2 values ranged from 0,46 to 0,82. The intraclass correlation showed the questionnaire reproducibility coefficients lower than the Pearson correlation. However, most of them remained at a value of >0,60.Conclusion. The results showed predominantly moderate validity and good reproducibility of the modern FFQ version, which allows it to be used to assess nutrition in the adult population with estimation of the energy and nutritional value of diet in the protocols of Russian epidemiological, preventive and clinical studies.
METAPHOR STORY AS AN ACTIVE LEARNING MEDIA TO INCREASE CHILDREN SOCIAL CHARACTER
Authors: Mashar Riana 
Published: March 2022

This research describe the effectiveness of the metaphor story as an active learning media to increase children social character. The research’s design was one group pretest-posttest design. Purposive samplingused to choose 20 students at second grade elementary school who have low social character skor. Based on teacher report, known that there were 20 student who had been lower social character than others. On this research, collecting data of child social character used observation checklist. Data was analysed by Wilcoxon Signed-Rank Test, only 19 that can analyze because one student did not complete the treatment. The result of study showed that metaphor story as active learning media increased children social character.This research describe the effectiveness of the metaphor story as an active learning media to increase children social character. The research’s design was one group pretest-posttest design. Purposive sampling used to choose 20 students at second grade elementary school who have low social character skor. Based on teacher report, known that there were 20 student who had been lower social character than others. On this research, collecting data of child social character used observation checklist. Data was analysed by Wilcoxon Signed-Rank Test, only 19 that can analyze because one student did not complete the treatment. The result of study showed that metaphor story as active learning media increased children social character.
MEDIA PAPAN PINTAR TERHADAP KEMAMPUAN MENGENAL LAMBANG BILANGAN ANAK USIA 5-6 TAHUN
Authors: Chentiya Chentiya , Zulminiati Zulminiati 
Published: March 2022

Penelitian yang dilakukan ini bertujuan untuk mengetahui pengaruh media papan pintar terhadap kemampuan mengenal lambang bilangan anak usia 5-6 tahun. Jenis penelitian ini merupakan penelitian kuantitatif dengan metode eksperimen dalam bentuk quasy eksperimen. Populasi dalam penelitian ini berjumlah 30 anak terbagi dalam 2 kelompok yaitu kelompik B1 (kelas eksperimen) dan kelompok B2 (kelas kontrol) di TK Hang Tua Padang. Sampel dalam penelitian ini dilakukan di dua taman kanak-kanak dikota padang kecamatan Nanggalo. Teknik pengambilan sampel penelitian menggunakan teknik sampling jenuh. Teknik pengumpulan data menggunakan test dengan 10 butir item instrument pernyataan. Teknik analisis dengan cara membandingkan perbedaan dari dua rata-rata nilai, sehingga dilakukan uji t (t-tes) dengan bantuan program SPSS 22 for windows. Namun sebelumnya melakukan uji normalitas dan uji homogenitas terlebih dahulu. Hasil penelitian ini menunjukan bahwa : terdapat pengaruh yang signifikan terhadap kemampuan mengenal lambang bilangan anak usia 5-6 tahun di Hang Tua Padang, yaitu dengan hasil Ho ditolak dan Ha diterima. Dengan demikian dapat disimpulkan bahwa pengaruh media papan pintar lebih efektif dalam mengembangkan kemampuan mengenal lambang bilangan pada anak usia 5-6 tahun di TK Hang Tuah Padang.
REFRACTORY PRIMARY NOCTURNAL ENURESIS AND URODYNAMIC STUDIES, IS IT MANDATORY?
Authors: Bajalan Diar 
Published: March 2022

Background
Enuresis is another meaning of intermittent nocturnal incontinence. It is a frequent symptom in children, with a prevalence of 5-10% at seven years of age, and is considered among the most prevalent conditions in childhood.
Objectives
To detect any Urodynamic study findings in patients presented with refractory primary nocturnal enuresis.
Patients and Methods
A prospective study was done for fifty patients who presented with pure Primary bedwetting (Monosymptomatic), {26 males and 24 females}, their age ranges from (5 to 24 years), who attended the Urodynamic section in the Urology Department, for the period: November 2010 till December 2014 after taking Medico-legal consent from all of them and performing a complete assessment for the patients.
Results
Regarding Urodynamic Study, nine patients (18%) had typical study, 24 patients (48%) had Detrusor Over-Activity, eight patients (16%) had Detrusor Under-Activity, two patients (4%) had DSD (Detrusor-Sphincter Dys-synergia), three patients (6%) had Detrusor Spasticity and one patient had Sphincteric deficiency. Regarding combined findings: one patient had Detrusor Under-Activity with DSD, one patient had Detrusor Over-Activity with Spasticity, and one patient had Detrusor Over-Activity with DSD.
Regarding the bladder capacity, seventeen patients (34%) had average bladder capacity, 28 patients (56%) had small bladder capacity and five patients (10%) had large bladder capacity.
Conclusion
According to our results, a significant percentage of the primary nocturnal enuretic patients had some Neuropathic Bladder. Does it recommend that every patient presented with Monosymptomatic Refractory Primary Nocturnal Enuresis do a Urodynamic study as their initial assessment? Besides, to find the exact type of abnormality and manage accordingly as soon as possible.
FACTORS ASSOCIATED WITH INSULIN ADHERENCE IN TYPE 1 DIABETIC CHILDREN ATTENDING JAMAL AHMED RASHID PAEDIATRIC TEACHING HOSPITAL IN SULAIMANIA CITY
Authors: Abdulrahman Alan 
Published: March 2022

Background
Type 1 diabetes mellitus is a chronic condition in the paediatric age group. Its treatment is always challenging for the affected child, the whole family, and the health care system. Reasonable control is usually the aim because it will prevent or delay the complications of diabetes. Adherence to insulin therapy is among the essential factors in the control of the disease.
Objectives
To identify factors that influence insulin adherence in children with Type 1 diabetes mellitus.
Patients and Methods
A cross-section study was done among type 1 diabetic children who have been registered in the diabetic centre in Dr Jamal Ahmed Rashid Paediatric Teaching Hospital from April 1st to September 30th, 2018.
All the affected 104 cases were below 16 years of age. Caretakers of the patient were interviewed using pretested questionnaires to provide information on socio-demographic characteristics. Insulin adherence was measured by the 8-Item Morisky Medication Adherence Scale (MMAS); furthermore, injection-related barriers to insulin injection were assessed.
Results
The mean age (±SD) of the 104 affected diabetic children was 7.07 ± 3.36 years. The male-to-female ratio was 1.04:1 (53 males and 51 females). Good adherence was found in 72.1% of the cases, 19.2% had an average adherence, with 8.7% were poorly adherent to therapy.
Conclusion
Most type 1 diabetic children had good adherence to insulin therapy with fair 1-2 blood glucose test monitoring per day. Family supervision of the insulin injections and blood sugar monitoring were the two significant factors in insulin adherence.
Featuring Content Writing in the Classroom
Authors: Fatma Anyassari Nugrahaningtyas 
Published: March 2022

Content writing has been gaining much attention. As many emerging enterprises go online, job vacancies for content writers are ubiquitous. Consequently, classroom activities, at polytechnics to be specific, should adjust with the current shift. This study aimed to describe content writing as a project in a Writing 3 class. The class consisted of 20 second-year students from the D4 English for Business and Professional Communication program. During a 5-week project, each student created a dummy business website on either Google sites or Blogger and performed as the main writer, contributor and editor. The business foci relied on their own interests which varied from fashion to merchandise and creative media. The results revealed that students were able to create excellent content for their websites. Pedagogical implications of this study may be to encourage designing a syllabus and instructional materials to teach content writing. It is suggested that future researchers include teachings on how to employ keywords in articles, and conduct interviews or surveys with actual content writers or related industries to support the course design.
Keywords: content writing, English for business communication, ELT
Działalność Pedagogicznej Biblioteki Wojewódzkiej im. prof. Tadeusza Kotarbińskiego w Łodzi w czasie pandemii
Authors: Wachowicz Monika , Figurska Katarzyna 
Published: March 2022

W artykule przedstawiono działalność Pedagogicznej Biblioteki Wojewódzkiej im. prof. Tadeusza Kotarbińskiego w Łodzi w okresie od 12 marca 2020 do 31 sierpnia 2021. Głównym celem było wskazanie sposobów i formy realizacji zadań Biblioteki w czasie pandemii, oraz dostosowania jej usług do okresowych obostrzeń.
Działania Książnicy Pedagogicznej im. A. Parczewskiego w Kaliszu w czasach pandemii roku 2020/2021
Authors: Zimna Aldona 
Published: March 2022

Celem artykułu jest prezentacja różnorodnych działań organizowanych przez Książnicę Pedagogiczną im. A. Parczewskiego w Kaliszu podczas pandemii od marca 2020 do września 2021 roku. Tekst zawiera przykłady tradycyjnych i elektronicznych usług bibliotecznych w ramach szerokiej oferty edukacyjno-kulturalnej, skierowanej do różnych grup użytkowników. Autorka opisała między innymi wystawy, konkursy i projekty realizowane przez Książnicę, także we współpracy z bibliotekami szkolnymi, wydziałem UAM/WPA w Kaliszu i Uniwersytetem Trzeciego Wieku. Podkreśliła wielką rolę popularyzowania działań biblioteki, które przenikają ze świata rzeczywistego w wirtualny poprzez media społecznościowe i stronę internetową Książnicy.
Model dan Strategi Kebijakan Investasi Sektor Pariwisata Untuk Pemerataan Pembangunan di Kabupaten Probolinggo
Authors: Puspita Yeni , Nugroho Margaretta Andini 
Published: March 2022

Taman Nasional Bromo Tengger Semeru (TNBTS), dipilih mewakili wisata Jawa Timur oleh Kementerian Pariwisata, namun investasi yang terealisasi belum dirasakan manfaatnya pada TNBTS dan masyarakat, kajian ini ingin melihat model dan strategi kebijakan investasi sektor pariwisata terhadap pembangunan ekonomi. Metode penelitian yang digunakan adalah kualitatif deskriptif yaitu melakukan wawancara pada pihak terkait dan melalukan kajian terhadap pelaksanaan investasi pada sektor pariwisata di Jawa Timur khususnya TNBTS. Bentuk investasi dalam sektor pariwisata adalah investasi dalam atraksi pariwisata, investasi dalam aksesbilitas pariwisata, investasi dalam amenitas pariwisata, dan investasi dalam ancillary pariwisata. Strategi investasi yang sustainable adalah rencana strategis yang berkelanjutan dengan menciptakan model 9 portofolio produk wisata itu untuk mendukung Atraksi; pembangunan aksesibilitas pariwisata di Jawa Timur, dengan cara pembenahan di sektor transportasi; pembangunan amenitas (fasilitas) pariwisata di Jawa Timur bisa dilakukan oleh pihak swasta; pelayanan tambahan harus disediakan oleh Pemerintah Daerah setempat.
High Neutrophil-Lymphocyte Ratio and Low Lymphocyte-Monocyte Ratio Combination After Thrombolysis is a Potential Predictor of Poor Functional Outcome of Acute Ischemic Stroke
Authors: Sadeghi Farzaneh , Sarkady Ferenc , Zsóri Katalin S. , Szegedi István , Orbán-Kálmándi Rita , Székely Edina G. , Vasas Nikolett , Berényi Ervin , Csiba László , Bagoly Zsuzsa , Shemirani Amir H. 
Published: March 2022

Abstract
Ischemic stroke is one of the leading causes of death and disability. An inflammatory response is observed in multiple stages of cerebral ischemia, particularly in the acute phase. Recent publications revealed that neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR) may be used to predict long term prognosis in acute ischemic stroke (AIS) after thrombolysis. To test whether there is a relationship between the combination of these parameters and long-term prognosis, we analyzed NLR-LMR combination in AIS patients treated with intravenous recombinant tissue plasminogen activator (rtPA). The study included 285 adults with diagnosis of AIS and rtPA treatment within 4.5h time window. Blood samples were obtained at admission and 24h after thrombolysis to calculate pre- and post-thrombolysis NLR and LMR. Clinical data including NIHSS was registered on admission and day 1. Long-term outcome was defined 90 days post-event by the modified Rankin Scale (mRS). Therapy-associated intracranial hemorrhage (ICH) was classified according to ECASS II. Receiver operating characteristic curve (ROC) analysis was performed to determine optimal cutoffs of NLR and LMR as predictors of therapy outcomes. Patients were stratified by cutoffs of 5.73 for NLR and 2.08 for LMR. Multivariate logistic regression model including all possible confounders displayed no significant association of NLR or LMR with 3-months functional prognosis. The combination of high NLR-low LMR in patients vs. low NRL-high LMR in patients as obtained 24h after thrombolysis was found to be an independent predictor of poor 3-months functional outcome (mRS ≥2; OR 3.407, 95% CI 1.449 to 8.011, p = 0.005). The proportion of patients between low NLR-high LMR and high NLR-low LMR groups from admission to day 1 showed no significant change in the good outcome group. On the other hand, in the poor outcome group (mRS ≥2), low NLR-high LMR and high NLR-low LMR groups displayed a significant shift of patient proportions from 67% and 21% at admission (p = 0.001) to 36% and 49% at 24h after thrombolysis (p < 0.001), respectively. Our study demonstrated for the first time that a high NLR-low LMR combination as observed at 24h after thrombolysis can serve as an independent predictor of 3-months poor outcome in AIS patients. This simple and readily available data may help clinicians to improve the prognostic estimation of patients and may provide guidance in selecting patients for intensified care post-thrombolysis.