bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous Room‐Temperature Hydrogen Release from Liquid Organic Carriers in a Photocatalytic Packed‐Bed Flow Reactor
Authors: Ibrahim Malek Y. S. , Bennett Jeffrey A. , Abolhasani Milad 
Published: April 2022

AbstractDespite the potential of hydrogen (H2) storage in liquid organic carriers to achieve carbon neutrality, the energy required for H2 release and the cost of catalyst recycling have hindered its large‐scale adoption. In response, a photo flow reactor packed with rhodium (Rh)/titania (TiO2) photocatalyst was reported for the continuous and selective acceptorless dehydrogenation of 1,2,3,4‐tetrahydroquinoline to H2 gas and quinoline under visible light irradiation at room temperature. The tradeoff between the reactor pressure drop and its photocatalytic surface area was resolved by selective in‐situ photodeposition of Rh in the photo flow reactor post‐packing on the outer surface of the TiO2 microparticles available to photon flux, thereby reducing the optimal Rh loading by 10 times compared to a batch reactor, while facilitating catalyst reuse and regeneration. An example of using quinoline as a hydrogen acceptor to lower the energy of the hydrogen production step was demonstrated via the water‐gas shift reaction.
Cytopathology of the distant metastasis of papillary carcinoma of thyroid
Authors: Shastri Malvika , Kundu Reetu , Rohilla Manish , Gupta Parikshaa , Gupta Nalini , Srinivasan Radhika , Saikia Uma Nahar , Dey Pranab 
Published: April 2022

AbstractAimsTo describe the cytomorphological features at distant metastatic sites apart from lymph nodes in papillary thyroid carcinoma (PTC).Materials and methodsA total of eight cytology cases from seven patients reported as metastatic papillary carcinoma of thyroid were reviewed including available clinical and radiological details. The details clinical and cytological features were studied.ResultsThere were a total of five males and two female patients. Two of these patients presented with lung nodules, two patients had bony lesion and lesion in kidney respectively and one patient had both bony and soft tissue lesions. Pleural fluid and bronchoalveolar lavage were received from remaining two patients. Cytology smears revealed papillary clusters and sheets of tumor cells, having round to oval nuclei with pale powdery chromatin, inconspicuous nucleoli and scant to moderate amount of cytoplasm. Nuclear features such as longitudinal nuclear grooves, intranuclear cytoplasmic inclusions were seen in all but one case. Nuclear enlargement and overlapping were variably present.ConclusionsThe diagnosis of metastatic PTC at uncommon locations is difficult. Since many of these locations are amenable to fine needle aspiration or exfoliative cytology evaluation, clinical awareness, and identification of classic cytomorphologic features can offer quick and accurate diagnoses. In cases with occult or unknown PTC presenting with metastases, cytomorphology may help in the prompt suggestion of detecting primary tumor in the thyroid.
Unpacking notions of residents' responsibility in flood risk governance
Authors: Snel Karin A. W. , Hegger Dries L. T. , Mees Heleen L. P. , Craig Robin Kundis , Kammerbauer Mark , Doorn Neelke , Bergsma Emmy , Wamsler Christine 
Published: April 2022

AbstractEnvironmental disasters, and especially floods, are among today's biggest sustainability challenges. The number and intensity of floods are increasing, challenging current governance approaches. Governments worldwide are looking to diversify their flood risk management and adaptation strategies, among others, by increasing resident involvement in flood risk governance. Such involvement of individuals shifts responsibilities from public to private actors. A clear understanding of the extent and implications of this shift is difficult to reach as theoretical perspectives on the concept of responsibility vary. Similarly, grounds for attributing responsibility for flood preparedness and response differ across countries. This lack of analytical and empirical clarity complicates academic and policy discourses on what it actually means to ‘be responsible’. The current article systematises these different approaches to responsibility in flood risk governance. To improve current knowledge on residents' responsibilities in flood risk governance, we present a conceptual framework that distinguishes among four theoretical notions of responsibility: legal responsibility, accountability, perceived responsibility, and moral responsibility. These notions are elucidated with the help of examples of flood risk governance practices in the United States, Germany and the Netherlands. We find that the four notions are closely intertwined. In addition, this article documents divergences between what individuals perceive as their own responsibility in flood risk management and the responsibilities that governments assume. We conclude with a discussion on the tensions between perceived responsibilities and the other three notions. Explicit, transparent and open discussion on these tensions is needed to allow attribution of responsibility in flood risk governance and to reconsider residents' roles in particular.
Emergent geographies of chronic air pollution governance in Southeast Asia: Transboundary publics in Singapore
Authors: Varkkey Helena 
Published: April 2022

AbstractHaze is a product of in‐situ biomass fires that becomes mobile as it moves across state boundaries in Southeast Asia. The literature on the governance of transboundary air commons has largely been fixed at the national or supranational scalar of reference. Hence, successes and failures tend to be evaluated based on policy and diplomatic (non)progress. This paper contributes to recent literature that argues that haze should be treated as a challenge and opportunity for transboundary governance and not merely transnational governance. Transboundary governance does not restrict the study of cross‐border relations to national scales of analysis but encompasses resource connections that traverse borders at all scales of governance. This paper focuses on Singapore, a state where biomass fires do not occur but where the effects of haze are acutely felt. Among ASEAN member states, Singapore has been viewed as a particularly active player in region‐wide governance on haze. However, the role of non‐state environmental stewardship initiatives in pathfinding, nudging, and signalling state, corporate and regional actors towards emergent transboundary governance arrangements have been underplayed. By focusing on the efforts of the Singapore Institute of International Affairs (SIIA), Singapore Environment Council (SEC), and People's Movement to Stop Haze (PM Haze), this paper explores how transboundary publics can fill policy gaps in transnational haze governance regimes. As a highly depoliticised city‐state, Singapore's experience serves as a microcosm for ways forward within the broader ASEAN geopolitical culture favouring depoliticised ‘engaged non‐indifference’.
Study on distortion energy and stability of gob floor based on stress deviator field
Authors: Shan Renliang , Li Zhaolong , Wang Chunhe , Meng Chi , Wei Yonghui , Li Yongzhen , Tong Xiao , Liu Dong 
Published: April 2022

AbstractTo analyze the plastic failure process and mechanism of gob floor in the process of close‐distance coal seams mining, a simplified mechanical model of the lateral abutment pressure of the gob was proposed to derive the stress of surrounding rock. The distribution characteristics of gob floor stress deviator were obtained, and the effect of geological parameters (coal depth H and horizontal lateral pressure coefficient λ) were studied. By combining Mohr–Coulomb theory, the influence of surrounding rock cohesion c, internal friction angle φ, different coal seam depths H and different horizontal lateral pressure coefficients λ on the distribution of plastic zone of gob floor was obtained. The results showed that the distribution of the plastic zone under different geological factors is roughly the same as that of the stress deviator. This also proves that the excavation of the rock layer causes the redistribution of stress, which leads to the plastic failure of the surrounding rock. To verify the rationality of the proposed model, industrial experiments and simulation experiments were carried out. The results of on‐site investigation showed that the stability and integrity of surrounding rock in the concentration area of stress deviator is far less than that in the low concentration area. In addition, the acoustic wave test and the displacement field monitoring result of surrounding rock in the simulation experiments of a similar model are basically consistent with the distribution of the stress deviator field. These results agree well with the distribution of stress deviator obtained by theoretical calculation.
Stimuli‐responsive crosslinked nanomedicine for cancer treatment
Authors: Xue Xiangdong , Qu Haijing , Li Yuanpei 
Published: April 2022

AbstractNanomedicines are attractive paradigms to deliver drugs, contrast agents, immunomodulators, and gene editors for cancer therapy and diagnosis. However, the currently developed nanomedicine suffers from poor serum stability, premature drug release, and lack of responsiveness. Crosslinking strategy can be utilized to overcome these shortcomings by employing stimuli‐responsive chemical bonds to tightly hold the nanostructure and releasing the payloads spatiotemporally in a highly controlled manner. In this Review, we summarize the recently ingenious design of the stimuli‐responsive crosslinked nanomedicines (SCN) in the field of cancer treatment and their advances in circumventing the drawbacks of the conventional drug delivery system. We classify the SCNs into three categories based on the crosslinking strategies, including built‐in, on‐surface, and inter‐particle crosslinking nanomedicines. Thanks to the stimuli‐responsive crosslinkages, SCNs are capable of keeping robust stability during systemic circulation. They also respond to the particular tumoral conditions to experience a series of dynamic changes, such as the changes in size, surface charge, targeting moieties, integrity, and imaging signals. These characteristics allow them to efficiently overcome different biological barriers and substantially improve the drug delivery efficiency, tumor‐targeting ability, and imaging sensitivities. With the examples discussed, we envision that our perspectives can inspire more attempts to engineer intelligent nanomedicine to achieve effective cancer therapy and diagnosis.
Cell‐cultivated food production and processing: A review
Authors: Barzee Tyler J. , El Mashad Hamed M. , Cao Lin , Chio Allan , Pan Zhongli , Zhang Ruihong 
Published: April 2022

AbstractCells cultivated in bioreactors offer many possibilities for the production of novel and nutritious food products. Scientific and technological advances in cellular agriculture and processing technologies have allowed for the development of new techniques to utilize in vitro animal cells, plant cells, and microorganisms to mimic the organoleptic and nutritional properties of traditional foods as well as to potentially develop entirely new product classes. This review compiles and discusses the state‐of‐the‐art cellular production and processing systems including 3D printing of customizable cell‐cultivated food products. In addition to the technological state‐of‐the art, this article reviews the nutritional characteristics of cell‐cultivated foods, introduces examples of new food products, and compiles economic characteristics and environmental impacts of each production system as assessed through technoeconomic analyses and lifecycle assessments. The factors influencing consumer acceptance of cell‐cultivated foods are articulated and the potential implications of these new technologies on traditional agricultural industries and food chains are discussed. Lastly, future research and development trajectories are introduced with suggestions for continued development.
Perturbing electron carriers of green algae Chlamydomonas reinhardtii for efficient physiological and metabolic regulation
Authors: Zhou Dongqing , Luo Yeling , Zhang Yingqiu , Zhao Chenni , Wu Hui , Fan Jianhua 
Published: April 2022

AbstractMicroalgae are widely used in the field of food bioengineering. There are relatively few studies on the synthesis of intracellular electron carriers in microalgae and their related metabolic effects. In this study, overexpression of Geranyl diphosphate: 4‐hydroxybenzoate geranyltransferase (lepgt), and the addition of 4‐hydroxybenzoic acid (4‐HB) as quinone ring precursor were adopted to regulate intracellular plastoquinone (PQ) and ubiquinone (UQ) levels in model algae Chlamydomonas reinhardtii. Small changes in PQ and UQ contents could regulate cell growth and metabolism. The expression of lepgt in C. reinhardtii significantly reduced the intracellular contents of PQ and UQ by 49.14% and 98.30%, respectively. The expression of lepgt observably reduced the photosystem activity and respiration rate and increased the contents of neutral lipid and starch by 63.68% and 19.42%, respectively. Exogenous low concentration of 4‐HB (1 mM) can effectively improve the contents of intracellular electron carriers, promote respiration, slightly reduce photosystem efficiency, and increase the maximum specific growth rate by 16.93%. It decreased the protein and oil contents by 15.48% and 15.10%, as well as changed the composition of long‐chain fatty acids. This paper provided a novel strategy for developing microalgal cell factories for future food production by perturbation on electron carriers of green algae.
Prenatal substance use policies and newborn health
Authors: Meinhofer Angélica , Witman Allison , Maclean Johanna Catherine , Bao Yuhua 
Published: April 2022

AbstractWe study the effect of punitive and priority treatment policies relating to illicit substance use during pregnancy on the rate of neonatal drug withdrawal syndrome, low birth weight, low gestational age, and prenatal care use. Punitive policies criminalize prenatal substance use, or define prenatal substance exposure as child maltreatment in child welfare statutes or as grounds for termination of parental rights. Priority treatment policies are supportive and grant pregnant women priority access to substance use disorder treatment programs. Our empirical strategy relies on administrative data from 2008 to 2018 and a difference‐in‐differences framework that exploits the staggered implementation of these policies. We find that neonatal drug withdrawal syndrome increases by 10%–18% following the implementation of a punitive policy. This growth is accompanied by modest reductions in prenatal care, which may reflect deterrence from healthcare utilization. In contrast, priority treatment policies are associated with small reductions in low gestational age (2%) and low birth weight (2%), along with increases in prenatal care use. Taken together, our findings suggest that punitive approaches may be associated with unintended adverse pregnancy outcomes, and that supportive approaches may be more effective for improving perinatal health.
The “m6A writer” METTL3 and the “m6A reader” IGF2BP2 regulate cutaneous T‐cell lymphomas progression via CDKN2A
Authors: Wang Xinchen , Hu Maogui , Yu Lu , Wang Xiaoyan , Jiang Xinlu , Zhang Guihong , Ding Kaiyang 
Published: April 2022

AbstractIt has been established that Cutaneous T‐Cell lymphomas (CTCL) are caused by the monoclonal proliferation of T lymphocytes in the skin. This heterogeneous group of diseases represents a significant source of distress to patients since the diagnosis and treatment are often challenging. As one of the most abundant internal modifications in mRNA in higher eukaryotes, N6‐methyladenosine (m6A) is widely recognized to affect the development and progression of cancers. However, knowledge on the involvement of m6A in CTCL is still limited. In this work, we revealed the role of METTL3‐mediated m6A modification in CTCL progression. ELISA, western blot, and qRT‐PCR assays demonstrated that METTL3 was significantly downregulated in CTCL cells both in vivo and in vitro. CCK‐8, EdU, flow cytometry, and transwell assays showed that the decline in METTL3 levels was responsible for CTCL cell proliferation and migration. Furthermore, using small interfering RNAs against METTL3 and the RIP assay, we showed that CDKN2A was a key regulator during this process in vitro and in vivo, and insufficient methylation modification blocked the interaction between CDKN2A and m6A reader IGF2BP2, resulting in mRNA degradation. To the best of our knowledge, this is the first study to depict the role of m6A in CTCL development and provide potential bio‐targets for therapy.
A PETAR method for risk assessment of human health and environment on the regional scale
Authors: Guo Kai , Liu Yang , Lan Zeying , Qin Liangjun , Lin Tong , Gan Qiao , Jin Bingbing , Chen Min 
Published: April 2022

Abstract
Risk assessments are necessary to effectively reveal the state of the degradation of living environments on a regional scale. However, risk assessments are often limited by time, cost, and technology, which make conducting effective evaluations difficult. Thus, in this study, the procedure for ecological tiered assessment of risk (PETAR) method was used to analyze the human health and environmental risks in Daye, China. This method first used the United States Environmental Protection Agency's risk assessment approach to qualitatively determine the risk sources, pressures, receptors, and effect endpoints and constructed a conceptual model of threats to the human living environment. Each risk-prone subregion was then evaluated using the fuzzy logic method. Next, a quantitative assessment was conducted for the subregions with the most serious environmental degradation. Finally, quantitative analyses were performed to verify the original hypotheses. The results showed that the high-risk areas were distributed in the industrial regions of Daye, wherein mining and processing clusters and mining settlements are widespread and confirmed the locations of the particular subregions with the most serious human health and environmental risks. This study also validated the practicality of the PETAR method for human health risk assessments in mining areas with large-scale, multifactor, and multihazard paths. Integr Environ Assess Manag 2023;19:239–253. © 2022 SETAC
Diagnosis value of miR‐181, miR‐652, and CA72‐4 for gastric cancer
Authors: Tian Wenyan , Pang Xueqin , Luan Fujuan 
Published: April 2022

AbstractPurposeTo find a useful disease marker for early diagnosis of gastric cancer, we tried to explore the expression of serum miR‐181, miR‐652, and carbohydrate antigen 72‐4 (CA72‐4).Patients and MethodsAccording to clinical pathologic stages, 112 patients with gastric cancer were divided into early gastric cancer group (n = 60) and advanced gastric cancer group (n = 52), stage I‐II (n = 65), and stage III‐IV (n = 47). Another 50 cases of gastric benign lesions and 40 healthy controls were also selected. Real‐time quantitative PCR together with chemiluminescence were applied to detect expression levels. ROC curve was applied to judge their diagnostic efficiency. Pearson's correlation analysis was put into use to investigate the relevance of three indicators.ResultsCompared with benign lesions group and control group, significantly higher expression levels were found in patients of gastric cancer (all p < 0.001). Similarly, compared with early gastric cancer group, significantly higher expression levels were found in advanced gastric cancer group (all p < 0.001). The same result was also found in stage III‐IV (all p < 0.001). The best cutoff values were 0.93, 2.38, and 16.94 U/ml, respectively. The area under the curve (0.917, 95%CI: 0.856–0.975) of the three combined diagnosis of early gastric cancer was the largest, and its sensitivity and specificity were 92.5% and 86.8%. And miR‐181 and miR‐652 were positively correlated with CA72‐4 (r = 0.772, p < 0.001, r = 0.853, p < 0.001).ConclusionSerum miR‐181, miR‐652, and CA72‐4 are closely linked to the occurrence and development of gastric cancer. Combination of three indicators has diagnostic value for early gastric cancer.
hsa_circ_0000285 facilitates thyroid cancer progression by regulating miR‐127‐5p/CDH2
Authors: Zhang Bowei , Li Qiaoling , Song Zhe , Ren Li , Gu Yi , Feng Chao , Wang Jinju , Liu Tong 
Published: April 2022

AbstractThyroid cancer (THCA) is a leading endocrine cancer and becomes the fifth most commonly diagnosed malignancy in females. It is confirmed that circular RNAs (circRNAs) perform regulatory potencies in the pathological progress of THCA. Our purpose was to certify the trait of hsa_circ_0000285 (circ_0000285) and investigate its modulatory mechanism in THCA progression. We identified the expression profile of hsa_circ_0000285 in THCA by conducting qRT‐PCR assay. Therewith, the potential of hsa_circ_0000285 in THCA development was determined with a set of functional experiments, including CCK‐8, wound healing assay, Western blot, and xenograft model. The molecular mechanism underlying hsa_circ_0000285 was investigated with bioinformatic analysis, RIP and dual‐luciferase reporter experiments. As opposed to normal samples and cells, hsa_circ_0000285 level was overtly increased in THCA specimens and cells. The downregulation of hsa_circ_0000285 weakened the proliferative and migratory capacity of THCA cells and promoted cell apoptosis. In addition, hsa_circ_0000285 silence suppressed the tumor growth of xenograft model mice in vivo. Notably, we demonstrated that hsa_circ_0000285 might target miR‐127‐5p/CDH2 axis in THCA. Afterward, our findings manifested that miR‐127‐5p attenuation blocked the function of hsa_circ_0000285 depletion in THCA cells. In the final step, CDH2 was proven to mediate the repressive potency of miR‐127‐5p in the malignant behaviors of THCA. Mechanistically, hsa_circ_0000285 induced the development of THCA via functioning as a competing endogenous RNA (ceRNA) of miR‐127‐5p to enhance CDH2 expression, which provided a new perspective for THCA therapy.
Mechanism of action, resistance, synergism, and clinical implications of azithromycin
Authors: Heidary Mohsen , Ebrahimi Samangani Ahmad , Kargari Abolfazl , Kiani Nejad Aliakbar , Yashmi Ilya , Motahar Moloudsadat , Taki Elahe , Khoshnood Saeed 
Published: April 2022

AbstractBackgroundAzithromycin (AZM), sold under the name Zithromax, is classified as a macrolide. It has many benefits due to its immunomodulatory, anti‐inflammatory, and antibacterial effects. This review aims to study different clinical and biochemisterial aspects and properties of this drug which has a priority based on literature published worldwide.MethodsSeveral databases including Web of Science, Google Scholar, PubMed, and Scopus were searched to obtain the relevant studies.ResultsAZM mechanism of action including the inhibition of bacterial protein synthesis, inhibition of proinflammatory cytokine production, inhibition of neutrophil infestation, and macrophage polarization alteration, gives it the ability to act against a wide range of microorganisms. Resistant organisms are spreading and being developed because of the irrational use of the drug in the case of dose and duration. AZM shows synergistic effects with other drugs against a variety of organisms. This macrolide is considered a valuable antimicrobial agent because of its use as a treatment for a vast range of diseases such as asthma, bronchiolitis, COPD, cystic fibrosis, enteric infections, STIs, and periodontal infections.ConclusionsOur study shows an increasing global prevalence of AZM resistance. Thus, synergistic combinations are recommended to treat different pathogens. Moreover, continuous monitoring of AZM resistance by registry centers and the development of more rapid diagnostic assays are urgently needed.