bluuebunny/crossref_metadata_2025_split huggingface dataset:
Criticality and Heterogeneity as General Principles to Optimize Performance for Spiking Cameras
Authors: Jin Chao , Wang Chen , Qi Xin , Wang Zhijun , He Yuan , Yu Lianchun 
Published: November 2022

Abstract
As a bioinspired sensor with high temporal resolution, the spiking cameras have enormous potential in real applications, yet it remains largely unknown how to improve their performance. In this study, we showed that the dynamic range of neuronal networks could be maximized jointly by critical dynamics resulting from balanced excitatory and inhibitory synaptic currents and the heterogeneity in the resting potentials of neurons in the networks. We then built a spiking camera to demonstrate that its performance, characterized by the peak signal-to-noise ratio (PSNR) and the structural similarity index measure (SSIM), could be optimized if the critical dynamics and heterogeneity were included in its core module. we argue that criticality and heterogeneity can serve as basic optimization principles of neuromorphic device design to improve their performance.
Systemic Paracoccidioidomycosis in a Patient With Enzymatic Myeloperoxidase Deficiency and Acute Lymphoblastic Leukemia: Case Report
Authors: Hoyos Sebastian , Quintero Cristián Camilo Agudelo , Lozano Diana Mercedes , Naranjo Luis Eduardo Buitrago 
Published: November 2022

Abstract
Background:
Paracoccidioidomycosis is a systemic fungal infection that is potentially fatal, and the most prevalent of its kind in Latin America. The predisposition to infection appears to be related to abnormalities in cellular immunity, given its low prevalence in endemic regions. The role of myeloperoxidase deficiency has not been elucidated.
Case presentation:
We present a case of 48-year-old female patient with acute lymphoblastic leukemia, stem cell transplant candidate, who developed a fever with lymphadenopathy and lung nodules, consistent with paracoccidioidomycosis infection, in whom a myeloperoxidase deficiency was later discovered. The treatment of the hematologic malignancy had a good impact solving the enzymatic deficiency and antifungal therapy achieve controlling the infection.
Conclusions:
This case lays out the possible association between acute leukemia, an alteration in neutrophil function (needed to fight fungal infections) and an infection due to Paracoccidioides brasiliensis.
A literature review of methods for assessment of reproducibility in science
Authors: Nordling Torbjörn , Peralta Tomas Melo 
Published: November 2022

Abstract

Introduction: In response to the US Congress petition, the National Academies of Sciences,
Engineering, and Medicine investigated the status of reproducibility and replicability
in science. A piece of work is reproducible if the same results can be obtained while following
the methods under the same conditions and using the same data. Unavailable data,
missing code, and unclear or incomplete method descriptions are common reasons for failure
to reproduce results.
Objectives: The motivation behind this review is to investigate the current methods
for reproducibility assessment and analyze their strengths and weaknesses so that we can
determine where there is room for improvement.
Methods: We followed the PRISMA 2020 standard and conducted a literature review
to find the current methods to assess the reproducibility of scientific articles. We made
use of three databases for our search: Web of Science, Scopus, and Engineering Village.
Our criteria to find relevant articles was to look for methods, algorithms, or techniques
to evaluate, assess, or predict reproducibility in science. We discarded methods that were
specific to a single study, or that could not be adapted to scientific articles in general.
Results: We found ten articles describing methods to evaluate reproducibility, and
classified them as either a prediction market, a survey, a machine learning algorithm, or a
numerical method. A prediction market requires participants to bet on the reproducibility
of a study. The surveys are simple and straightforward, but their performance has not been
assessed rigorously. Two types of machine learning methods have been applied: handpicked
features and natural language processing.
Conclusion: While the machine learning methods are promising because they can be
scaled to reduce time and cost for researchers, none of the models reviewed achieved an
accuracy above 75%. Given the prominence of transformer models for state-of-the-art natural
language processing (NLP) tasks, we believe a transformer model can achieve better
accuracy.
Determining the changes in metabolites of Dendrobium officinale juice fermented with starter cultures containing Saccharomycopsis fibuligera FBKL2.8DCJS1 and Lactobacillus paracasei FBKL1.3028 through untargeted metabolomics
Authors: Liu Wanlin , Luo Xiaoye , Qiu Shuyi , Huang WU , Su Yanan , LI Linling 
Published: November 2022

Abstract
Background
The present study aimed to investigate the changes in volatile components and metabolites of Dendrobium officinale (D. officinale) juice fermented with starter cultures containing Saccharomycopsis fibuligera and Lactobacillus paracasei at 28 ℃ for 15 days and post-ripened at 4 ℃ for 30 days using untargeted metabolomics of liquid chromatography-mass spectrometry (LC-MS) and headspace solid-phase microextraction-gas chromatography (HS-SPME-GC-MS) before and after fermentation.
Results
The results showed that the alcohol contents in the S. fibuligera group before fermentation and after fermentation were 444.806 ± 10.310 µg/mL and 510.999 ± 38.431 µg/mL, respectively. While the alcohol content in the fermentation broth group inoculated with the co-culture of L. paracasei + S. fibuligera was 504.758 ± 77.914 µg/mL, with a significant increase in the contents of 3-Methyl-1-butanol, Linalool, Phenylethyl alcohol, and 2-Methyl-1-propanol. Moreover, the Ethyl L (-)-lactate content in the co-culture L. paracasei + S. fibuligera group (7.718 ± 6.668 µg/mL) was higher than those in the L. paracasei (2.798 ± 0.443 µg/mL) and S. fibuligera monoculture groups (0 µg/mL). The co-culture of L. paracasei + S. fibuligera significantly contributed to the metabolic production of ethyl L (-)-lactate in D. officinale juice. The total number of differential metabolites screened after fermentation mainly included alcohols, organic acids, amino acids, nucleic acids, and their derivatives. Of them, twenty-three metabolites were significantly up-regulated in the ten key metabolic pathways of the co-culture L. paracasei + S. fibuligera group, including 11 types of acids. Furthermore, the metabolic pathways, such as pentose and glucuronate interconversions, the biosynthesis of alkaloids derived from terpenoid and polyketide, and aminobenzoate degradation were significantly upregulated in this group. These three metabolic pathways facilitate the synthesis of bioactive substances, such as terpenoids, polyketides, and phenols, and enrich the flavor composition of D. officinale juice.
Conclusions
The study results demonstrated that the co-culture of L. paracasei + S. fibuligera could promote the flavor harmonization of fermented products, and provide a theoretical basis for the study of the flavor of D. officinale juices and the functional investigation of fermentation metabolites.
Spontaneous Surgical Intracranial Haemorrhages Associated with SARS-Cov-2 infection: Case Report
Authors: Idowu Jeuel Ogooluwa , Idowu Olufemi Emmanuel , Adeniran Abimbola 
Published: November 2022

Abstract
Introduction:

To report spontaneous surgical acute and chronic intracranial haemorrhage in patients with SARS-Cov-2 infection.

Case Presentation:

We report two cases of SARS-CoV-2 infection that was associated with spontaneous surgical acute and chronic intracranial haemorrhage. The two patients had successful surgical intervention.

Conclusion:

Surgical haemorrhages should be considered in patients with SARS-COV-2 infection especially if there is associated altered sensorium.
A Mechanistic Study of Analgesic and Anticancer Activity of unexplored plant Strobilanthes Kunthiana Phytocosntituents using Molecular Docking Studies.
Authors: Arya Girish Chandra , Jakhmola Vikash , Mehla Shefali , Bainsal Neeraj 
Published: November 2022

Abstract
Background: Cancer is one of the leading causes of death worldwide, and the pain associated with it is very intense. Plants are a significant source of medications, particularly anticancer and analgesic medicines. One significant plant, Strobilanthes Kunthiana, is well-known for its assortment of medical applications. As a result, additional studies were carried out using these two Phytocosntituents, lupeol and betulin, to examine their analgesic and anticancer characteristics using PDB IDs 2MUB and 4XI3. The examination on the basis of molecular docking and ADME profiles served as the foundation for this study.
Objective: Based on molecular docking investigations, to suggest a mechanism of Strobilanthes Kunthiana Phytocosntituents for anticancer and analgesic activity.
Method: Molecular docking studies of Phytoconstituents of Strobilanthes Kunthiana were performed using the PyRx Virtual Screening software.
Results:According to the results of molecular docking, numerous ingredients, such as lupeol and betulin exhibit higher dock scores better than standard medications against analgesic and anticancer targets.
Conclusion: Based on molecular docking studies. Various chemical constituents may act as effective inhibitors of various proteins 2MUB, 4XI3. This information can be used to design new anticancer medicines.
Influence stacking sequence and heat-treatments on the out-of-plane mechanical properties of 3D printed fiberglass-reinforced thermoplastics
Authors: Hermosilla Rodolfo , Oñate Angelo , Castillo Rodrigo , Fuente Andres De la , Sepúlveda Joaquín , Escudero Benjamin , Vargas-Silva Gustavo , Melendrez Manuel , Medina Carlos 
Published: November 2022

Abstract
Additive manufacturing of composite materials is a promising technology. It could solve one of the most critical drawbacks of 3D-printed fiber-reinforced thermoplastics: their low out-of-plane mechanical properties. However, due to their novelty, the number of standards and research papers addressing the characterization of these materials is scarce, especially in the out-of-plane direction. Due to this factor, it is still unknown how most design and manufacturing parameters affect the out-of-plane properties of composite materials. As a solution, this paper proposes an experimental methodology to characterize out-of-plane printed composite materials. For this purpose, existing standards for traditionally fabricated composites are adapted, investigated, and validated for 3D-printed laminates reinforced with long fibers using the fused filament fabrication technique. Consequently, the methodology is employed to study the impact of stacking sequence and heat treatment conditions on the composites' out-of-plane mechanical properties. The main results showed that increasing the thickness between stacking layers increases the mechanical response due to reducing the number of fiber/matrix interfaces and, consequently, the reduction of porosity. Compared to the initial sample, a heat treatment at 175°C for 6 hours increased the interfacial strength by 101.09% and reduced the porosity in the fiber produced by the additive manufacturing process by 72%.
Epidemiological and clinical characteristics of elderly burns：A 15-year retrospective analysis of 2554 cases in Wuhan Institute of Burns
Authors: Wu Hong , Xi Maomao , Xie Weiguo 
Published: November 2022

Abstract
Background
With the increase of geriatric burns, it’s urgent to summarize its characteristics. The aim of this study was to analyze the epidemiological and clinical characteristics of burn in the elderly in a large center, and to provide suggestions for the prevention and treatment of geriatric burns.
Methods
This retrospective study was conducted at Wuhan Institute of Burns which is the largest burn center in central China between 2004 to 2018. Demographic and clinical data of the 60 years or above older burn inpatients were collected from medical records, analyzed and compared among groups.
Results
This study analyzed 2554 elderly burns, which included 50.9% in young geriatric group (60–69 years old), 32.9% in middle geriatric group (70–79 years old) and 16.2% in the oldest geriatric group (80 years old or above). The most common causes of elderly burns were flames (1081, 42.3%) and scalding (1041, 40.8%). Elderly burns with total body surface area (TBSA) of 0–9% accounted for 60.6% and the larger TBSA, the fewer number of patients. The majority of patients (70.5%) injured at home.The median of time interval from injury to admission was 7 hours and the oldest geriatric group (24 hours) was highest. One hundred and twenty-one cases (8.5%) were treated by cooling treatment, and 72.7% of these patients were treated less than 10 minutes. The median number of pre-injury diseases was one. Ninety patients (6.3%) had inhalation injury.The median length of stay (LOS) was 14 days.The median hospital cost was 10410 CNY or 2137 CNY per % TBSA, which was correlated with TBSA, LOS, surgery, inhalation injury, number of pre-injury diseases and etiology. The mortality rate was 3.0% and correlated with TBSA, inhalation injury, pulmonary disease and Alzheimer’s disease.
Conclusion
Geriatric burns was still common and even increasing in central China, with flame burns and scalds the most common causes, majority of whom injured at home and often had problems such as few cooling treatment, improper emergency management and delayed admission. TBSA, etiology, pre-injury diseases and inhalation injury were the risk factors of length of stay, hospital cost and treatment outcomes.
GRF-GIF chimeric proteins enhance in vitro regeneration and Agrobacterium-mediated transformation efficiencies of lettuce (Lactuca spp.)
Authors: Bull Tawni Ann , Debernardi Juan , Reeves Megan , Hill Theresa , Bertier Lien , Deynze Allen Van , Michelmore Richard W 
Published: November 2022

Abstract
The ability of plants to regenerate in vitro has been exploited for use in tissue culture systems for plant propagation, plant transformation, and genome editing. The success of in vitro regeneration is often genotype dependent and continues to be a bottleneck for Agrobacterium-mediated transformation and its deployment for improvement of some crop species. Manipulation of transcription factors that play key roles in plant development such as BABY BOOM, WUSCHEL, and GROWTH REGULATING FACTORs (GRFs) has improved regeneration and transformation efficiencies in several plant species. Here, we compare the efficacy of GRF-GIF gene fusions from multiple species to boost regeneration efficiency and shooting frequency in four genotypes of wild and cultivated lettuce (Lactuca spp. L.). In addition, we show that GRF-GIFs with mutated miRNA 396 binding sites increase regeneration efficiency and shooting frequency when compared to controls. We also present a co-transformation strategy for increased transformation efficiency and recovery of transgenic plants harboring a gene of interest. This strategy will enhance the recovery of transgenic plants of other lettuce genotypes and likely other crops in the Compositae family.
Transnational online education in biochemistry during and after the COVID-19 pandemic in Binzhou Medical University：Challenges, strategies and outcome
Authors: Ahiafor Maxwell , Li Yanni , Zhang Xiaodan , Ren Qun 
Published: November 2022

Abstract
Background
Due to the global outbreak of the COVID-19 epidemic, schools were forced to shift teaching from face-face to online. During this period, a large number of studies on how to better carry out online teaching emerged. However, these studies were basically conducted with domestic students as teaching objects. The research on transnational online education conducted by overseas students is very limited.This case study aims to share the author's research and practical experience on transnational online teaching after the outbreak of the pandemic, and how to choose the appropriate teaching platform to ensure the quality of online teaching. I hope it can give some inspiration to others, and provide a reliable methodology for transnational online teaching.
Methods
We first conducted a questionnaire survey on the obstacles of transnational online learning of 64 international students from our school who were staying abroad. Then, we analyzed the reasons for these obstacles and timely changed the teaching platform and compared the results of the biochemistry exam conducted for 2018 spring class with those of 2018 fall class and the 2019 fall class, so as to verify the superiority of the DingTalk as a transnational online education platform.
Results
The results of the questionnaire showed that the main difficulties of overseas students in transnational online learning are poor network conditions and time difference. Because the teaching platform was separated from the interactive Q&A platform, resulting in poor interaction between teachers and students. By using DingTalk as an online teaching platform, the previous difficulties were overcome. In the spring class of 2018, the results of online study students' biochemistry were significantly lower than those of students in face-face study(t-test, p = 0.01). However, after the switch to the DingTalk platform, online students’ results in the 2018 fall Class(t-test, p = 0.35) and the 2019 fall-Class(t-test, p = 0.7) were equivalent to the academic performance of face-face students.
Conclusion
Through our exploration and application of Dingtalk software in transnational online education, we successfully solved the dilemma of overseas students' online learning, and also provided a feasible method for us to guarantee the efficacy of online teaching.
Genetic diversity of Apis cerana in Changbai Mountain
Authors: Liu Nannan , Wang Qi , Sun Zhiyu , Li Jieluan , Dong Yimeng , Li Fenglin , Niu Qingsheng 
Published: November 2022

Abstract
Apis cerana in Changbai Mountain is the only eastern honey bee ecotype in this area that is well-adapted to the local agricultural and ecological environment and is the representative of Apis cerana in Northeast China. We analyzed the genetic diversity and genetic characteristics of Apis cerana in Changbai Mountain using five microsatellite markers, a mitochondrial marker of a tRNAleu-CO Ⅱ fragment, and 21 morphological markers. Our results showed that the genetic diversity of Apis cerana in Changbai Mountain was better than that found in previous studies. There were 11 haplotypes, among which Haplotype Changbai Mountain 1 was the major haplotype. The JL-YB individuals were large, no genetic differentiation was found in Apis cerana of Changbai Mountain in Jilin Province, and the LN population was significantly different from the JL and HL populations. Based on the genetic diversity of Apis cerana in Changbai Mountain, we also suggested some strategies for the protection and utilization of the genetic resources of Apis cerana in Changbai Mountain.
Patterns of Work-Related Stress and Their Predictors Among Emergency Department Nurses and Emergency Medical Services Staff in a Time of Crisis: A Latent Profile Analysis
Authors: Charzyńska Edyta , Soola Aghil Habibi , Mozaffari Naser , Mirzaei Alireza 
Published: November 2022

Abstract
Purpose
Many studies have shown that a disease outbreak causes high stress among healthcare workers. However, there is a scarcity of data on various patterns of work-related stress during such a critical situation in this group. The main purpose of the study was to identify latent profiles of healthcare workers with similar combinations of levels of various work-related stressors during the COVID-19 pandemic and to examine their predictors.
Methods
A paper-and-pencil survey was conducted among 297 ED nurses and 219 EMS staff members working in educational and medical centers in Ardabil province, Iran. Data were collected using the Health and Safety Executive Management Standards Indicator Tool for measuring work-related stress. Latent profile analysis (LPA) was used to analyze the data.
Results
Five work-related stress profiles were identified: “high stress with a good understanding of one’s job role” (11.1%), “moderate stress” (41.9%), “relatively high stress with average demands and a very low understanding of one’s job role” (23.8%), “low stress” (18.0%), and “generally low stress but with very high job demands and relational conflicts” (5.2%). Age, marital status, service location, workplace, and the number of overtime hours significantly predicted profile membership.
Conclusion
The results of the study suggest the importance of incorporating various sources of stress and using LPA to analyze them when studying the work-related stress of healthcare workers during disease outbreaks. A deeper and more complex understanding of particular patterns of work-related stressors in ED nurses and EMS staff may help prevent the specific area of work-related problems. Moreover, identifying sociodemographic and work-related predictors of profile membership may be useful for preparing interventions better suited to healthcare workers’ needs.
Correlation of Opium Usage with Blood Pressure and Fasting Blood Sugar, based on Fasa PERSIAN Cohort Study Data
Authors: Deris Kimia , Farjam Mojtaba , Zareei Saeideh , Alkamel Abdolhakim , Kazemi Maryam 
Published: November 2022

Abstract
purpose
There is a belief that opium consumption has a protective effect on hypertension and diabetes as two important risk factors for cardiovascular disease. This study aims to investigate blood sugar and pressure between opium users and non-users.
Methods
This cross-sectional study is based on a FASA PERSIAN cohort study. Systolic, diastolic blood pressure, and fasting blood sugar were compared between opium users and non-users. A linear regression model was also used to adjust confounding factors’ effects. Data analysis is performed using version of 22spss software. Mean and standard deviation, frequency and frequency percentage, Independent t-test, Chi-square, ANOVA test, and linear regression model were used to analyze the data. The significance level was 0.05.
Results
In this study, 7428 adult people participated. The mean age of participants was 46.5 years. 27.05% of participants were opium users. The mean diastolic blood pressure was 73.18 mmHg in non-opium users; however, it was 70.95 mmHg in opium users(P = 0.000). The mean systolic blood pressure was 105.20 mmHg in opium users, but it was 107.78mmhg in non-users(P = 0.000). The mean Fasting Blood sugar was 86.75 and 85.88 mg/dl in non-opium users and users, respectively(P = 0.019).
Conclusion
In the presence of confounders such as age, sex, smoking, BMI, physical activity, and calorie intake, systolic and diastolic blood pressure were lower in opium consumers, but fasting blood sugar was higher in opium users. Considering the many side effects of these substances, the usage of opium is not recommended at all.