bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short, medium and long-term naturalistic follow-up of female adolescents with anorexia nervosa after multimodal outpatient treatment: clinical, personality and psychopathology evolution, process indicators and outcome predictors
Authors: Amianto Federico , Arletti Luca , Davico Chiara , Vesco Serena , Vitiello Benedetto 
Published: August 2022

Abstract
Purpose: Despite its severity and increasing prevalence, Anorexia nervosa (AN) has no completely satisfactory evidence-based treatments. Follow-up studies may enlighten outcome predictors and process indicators.Methods: 73 female AN participants were assessed at intake (T0), and at 6 (T1) and 12 (T2) months after an outpatient multimodal treatment, 19 were followed-up for 15 years (T3). Changes in diagnostic criteria were compared with the chi-square test. Clinical, personality and psychopathology evolution were tested with ANOVA for repeated measures. T0 features were compared among dropout, stable and healed participants. Healed and unhealed at follow-up were compared using Mann-Whitney-U test. Treatment changes were correlated with multivariate regression.Results: complete remission at T2 was reached in 64.4% participants and in 73.7% at T3. At T2 22% participants maintained a full diagnosis, and only 15.8% at T3. BMI significantly increased at each time point since T0. Among personality, persistence decreased and self-directedness increased between T0 and T2. Interoceptive awareness, drive to thinness, and impulsivity decreased after treatment. Parent-rated and adolescent-rated general psychopathology significantly reduced. Lower reward dependence and cooperativeness characterized the dropout group. The healed group displayed lower adolescent-rated aggressive and externalizing, and lower parent-rated delinquent behaviors. BMI, personality and psychopathology changes were related to each other.Conclusion: a 12-months outpatient multimodal treatment of mild to moderate AN adolescents produces an increase in BMI, an improvement in personality development, and reduces eating and general psychopathology. Lower relational abilities may obstacle healing. Approaches to treatment resistance should consider these features.Level of evidence: Level III: Evidence obtained from well-designed cohort or case-control analytic studies.
Impact of COVID-19 on Dental Care in New York State and Georgia
Authors: Puskas Caroline , Morse Stephen 
Published: August 2022

Abstract
Introduction:During the COVID-19 pandemic, there was an unprecedented, forced closure of dental offices worldwide. As American state recommendations differed considerably during this period, this research strives to better define the effects of this pause on dental care.Materials & Methods:A 16-question Qualtrics survey was sent to the membership of the New York State Dental Association (NYSDA) and Georgia Dental Association (GDA). Licensed, actively practicing dental members of the NYSDA and GDA (n = 680) answered questions about their practice demographics, appointment cancellations, reopening times, and the volume of individual dental procedures performed from March 1 through August 1, 2020, compared to the same 5-month period in 2019.Results:Demographic characteristics of respondent NYSDA and GDA members were statistically similar. Nonetheless, NYSDA members reported significantly larger decreases in provision of all types of dental procedures except for antibiotic prescription, including prophylaxis, elective care, emergent care, and specialty procedures.Discussion & Conclusions:All dental procedures declined significantly during the COVID-19 pandemic, with greater decrease in New York than in Georgia. This study raises concern about the negative impact of the pandemic on oral public health, and mandates both further research and clinical strategies to mitigate against this future risk.
Effect of venoarterial extracorporeal membrane oxygenation on left ventricular function in cardiogenic shock with aortic stenosis or mitral regurgitation: an experimental study in porcine model
Authors: Ostadal Petr , Vondrakova Dagmar , Popkova Michaela , Hrachovina Matej , Krüger Andreas , Janotka Marek , Naar Jan , Kittnar Otomar , Neuzil Petr , Mlcek Mikulas 
Published: August 2022

Abstract
Background
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is widely used in the treatment of patients experiencing cardiogenic shock (CS). However, increased VA-ECMO blood flow (EBF) may significantly impair left ventricular (LV) performance. The objective of the present study was to assess the effect of VA-ECMO on LV function in acute CS with concomitant severe aortic stenosis (AS) or mitral regurgitation (MR) in a porcine model.
Methods
Eight female swine (45kg) underwent VA-ECMO implantation under general anaesthesia and mechanical ventilation. Acute CS was induced by global myocardial hypoxia. Subsequently, severe AS was simulated by obstruction of the aortic valve, while severe MR was induced by mechanical destruction of the mitral valve. Haemodynamic and LV performance variables were measured at different rates of EBF rates (ranging from 1 to 4 L/min), using arterial and venous catheters, a pulmonary artery catheter, and LV pressure-volume catheter. Data are expressed as median (interquartile range).
Results
Myocardial hypoxia resulted in declines in cardiac output to 2.7 (1.9–3.1) L/min and LV ejection fraction to 15.2% (10.5–19.3%). In severe AS, increasing EBF from 1 to 4 L/min was associated with a significant elevation in mean arterial pressure (MAP), from 33.5 (24.2–34.9) to 56.0 (51.9–73.3) mmHg (P˂0.01). However, LV volumes (end-diastolic, end-systolic, stroke) remained unchanged, and LV end-diastolic pressure (LVEDP) significantly decreased from 24.9 (21.2–40.0) to 19.1 (15.2–29.0) mmHg (P˂0.01). In severe MR, increasing EBF resulted in a significant elevation in MAP from 49.0 (28.0–53.4) to 72.5 (51.4–77.1) mmHg (P˂0.01); LV volumes remained stable and LVEDP increased from 17.1 (13.7–19.1) to 20.8 (16.3–25.6) mmHg (P˂0.01).
Conclusion
Results of this study indicate that the presence of valvular heart disease may alleviate negative effect of VA-ECMO on LV performance in CS. Severe AS fully protected against LV overload, and partial protection was also detected with severe MR, although at the cost of increased LVEDP and, thus, higher risk for pulmonary oedema.
Surface Modifications of eight-electron Pd/Ag Superatomic Alloys
Authors: Barik Subrat , Chen Chih-Yuan , Chiu Tzu-Hao , Ni Yu-Rong , Gam Franck , Chantrenne Isaac , Kahlal Samia , Saillard Jean-Yves , liu chen-wei 
Published: August 2022

Abstract
Atomically precise thiolate-protected noble metal nanoclusters and their alloys are far more numerous than their selenium congeners, the synthesis of which remains extremely challenging. Herein, we account the synthesis of a series of atomically defined dithiophosph(in)ate protected eight-electron superatomic Pd/Ag nanoalloys [PdAg20{S2PR2}12], 2a-c (where R = OiPr, a; OiBu, b; Ph, c) via ligand exchange and/or co-reduction methods. The ligand exchange reaction on [PdAg20{S2P(OnPr)2}12], 1, with [NH4{Se2PR2}12] (where R = OiPr, or OnPr) leads to the formation of [PdAg20{Se2P(OiPr)2}12] (3) and [PdAg20{Se2P(OnPr)2}12] (4), respectively. Solid state structures of 2a, 2b, 3 and 4 unravel different PdAg20 metal frameworks from their parent cluster, originating from the different distributions of the eight-capping silver(I) atoms around a Pd@Ag12 centered icosahedron with C2, D3, Th and Th symmetries, respectively. Surprisingly ambient temperature crystallization of the reaction product 3 obtained by the ligand exchange reaction on 1 has resulted in the co-crystallization of two isomers in the unit cell with overall T (3a) and C3 (3b) symmetries, respectively. This is the first ever characterized isomeric pair among the selenolate-protected NCs. Density functional theory (DFT) studies further rationalize the preferred geometrical isomerism of the PdAg20 core.
RWE Pathway: The State-of-the-art of Patient Registries in Portugal
Authors: Pedrosa Hugo , Pereira Fábio , Carrilho Magda , Martins Catarina , Martins Ricardo , Cruz Pedro 
Published: August 2022

Abstract
Background: Patient registries are one of the main Real-World Data (RWD) sources, which enable different healthcare stakeholders to analyze clinical practice, benchmark them and foster better care. Despite the growing need of RWD, the current use of patient registries in Portugal is not fully understood. This study aims to identify and characterize patient registries in Portugal to set a baseline for future developments in this domain.Methods: A systematic literature review was conducted and complemented with a literature search to identify registries in Portugal.Results: The study identified 108 unique registries in Portugal, 76 collecting data exclusively from Portuguese population. Most belong to medical societies or health authorities and are implemented in hospitals. Cardiology, Oncology, Endocrinology, and Rheumatology are the most studied therapeutic areas. Conclusion: Most registries have a national scope, but several are being used to complement international ones. This practice is common in Europe since guidelines to standardize data collection and foster practice benchmark exist. The majority are owned by medical societies or health authorities and the therapeutic areas seem aligned with health technology innovation. In the future a repository of information needs to be developed that embeds existing registries, to foster collaboration between stakeholders and promote better care.
Stevia rebaudiana Bertoni leaf extract phytochemicals inhibit the Type 2 Diabetes mellitus receptor targets
Authors: Shahid Muhammad , Azfaralariff Ahmad , Govender Nisha , Zubair Muhammad , Najm Ahmed Abdulkareem , Khan Nazeer Hussain , Law Douglas , Fazry Shazrul 
Published: August 2022

Abstract
Stevia rebaudiana Betoni (SR) or the candy leaf herbal plant is widely consumed as a non-caloric natural sweetener in substitute of table sugar. The perennial plant is native to South America and is cultivated across the globe. Over the years, there has been an increasing scientific interest in Stevia leaves, which naturally inherent phytochemicals of potent pharmacological properties. Amongst the various pharmacological activities previously evident through in vitro or in vivo studies includes blood sugar regulators, antibacterial, and antiviral properties. Type 2 diabetes mellitus (T2DM), or adult-onset diabetes, is a chronic condition characterized as non-effective insulin production by the pancreas. As a result, blood sugar rises and leads to fatality under an extremely high blood sugar condition. In this study, a library of SR leaf phytochemicals was screened using a comprehensive computational approach for the identification of potential anti-T2DM drug compounds. The in silico inhibitory activities of SR phytochemicals against selected T2DM receptor targets (T2DMrTs) were measured by molecular docking analysis and the best complex, as indicated by the minimum binding affinity and extent of structural interactions, was validated further by molecular dynamics (MD) simulation using the GROMACS webserver. The SR phytochemicals were searched in open-source databases and the corresponding pharmacological properties were predicted by the SwissADME tool. The following proteins were set as the T2DMrTs: α-amylase, α-glucosidase, DPP-4, GLP-1R, PPAR-γ and PTP1B. A total of 177 SR phytochemicals were mined and further screening by molecular docking analysis and pharmacological evaluation identified 19 compounds satisfying the minimum binding energy set at < -7 kcal/mol, Lipinski’s rule of five, and oral bioavailability score. Under all possible receptor-ligand, pair-wise combinations, the complexes showed strong to good stability under a 50 ns MD simulation run. The findings inform new information on SR phytochemicals for T2DM therapeutics and drug development.
Impact of changing treatment strategy based on circulating tumor cells on postoperative survival of breast cancer
Authors: Wang Zihan , xu wei , Yang Yanlian , Gao Guoxuan , Teng Changsheng , Ge Zhicheng , Zhang Huiming , Yuan Zhu , Ding Guoqian , Wang Yang , Li Peixin , Xu Yaqian , Li Ping , Hu Zhiyuan , Zhang Zhongtao , Qu Xiang 
Published: August 2022

Abstract
Background: We sought to explore the impact of changing treatment strategy based on circulating tumor cells (CTC) on postoperative survival of breast cancer. Methods: We retrospectively analyzed records of patients who underwent surgery for early-stage breast cancer at Beijing Friendship Hospital from January 2016 to January 2018 and regularly underwent CTC examination after surgery. During the regular examination and CTC monitoring, the patients with positive CTC results and without distant metastasis had their treatment regimen changed.Results: Of 109 patients who received CTC examination regularly after surgery, 61 (56.0%) were CTC-positive during postoperative follow-up, including 33 ER or PR-positive, and 28 ER and PR-negative patients. Of the 33 ER or PR-positive patients, 20 changed endocrine therapy drugs. Compared with those without replacement, those with changed endocrine therapy strategy had higher CTC clearance rates (90.0% vs. 53.8%, p=0.04) and significantly lower CTC-positive values (1.70 ± 1.72 vs. 0.62 ± 0.65, p = 0.04). Among the 28 patients who were CTC positive and ER and PR-negative, 11 used capecitabine. Compared with non-users, the capecitabine users had higher CTC clearance rates (100.0% vs. 52.9%, p=0.01) and more significant decrease in CTC-positive values (2.09 ± 1.14 vs. 0.82 ± 1.67, p=0.04). Disease-free survival (DFS) at 1, 3, and 5 years was significantly longer in those who changed treatment than in those who did not (respectively, 96.6% vs. 89.6%, 92.8% vs. 56.9%, 69.0% vs. 47.8%, p<0.01). By changing the treatment strategy, CTC-positive patients achieved DFS that was not significantly different from CTC-negative patients (95.0% vs. 97.7%, 77.5% vs. 82.9%, 57.6% vs. 59.9%, p=0.20). Conclusion: Timely change of treatment strategy for breast cancer patients with positive CTC results after surgery may improve CTC clearance rate and DFS.
Intraspecific functional variability associated to mangrove forest zonation in West-Central Mexico
Authors: Campo Judit Torres Fernández del , Olvera-Vargas Miguel , Figueroa-Rangel Blanca L. , Cuevas-Guzmán Ramón , Casanoves Fernando 
Published: August 2022

Abstract
Functional diversity and the contribution of functional traits in mangrove ecosystems dynamics in western México remain unknown. In this study, we assessed intraspecific trait variation in three different mangrove zones. We developed and tested the following hypothesis: i. mangrove species vary along trait axes associated with plant size and leaf economics. ii. there is intraspecific trait variation (ITV) in leaf traits related to economic aspects of plant function among mangrove zones. iii. the presence of functional variation in plant traits among mangrove zones is related to physicochemical ground-water gradients. We used 65 permanent plots, distributed across three contrasting mangrove zones to assess morphological functional traits: leaf area, specific leaf area (SLA), leaf dry-matter content (LDMC), tree height (H) and wood density; salinity, dissolved oxygen, pH and temperature were recorded in each plot. Principal Component Analysis (PCA) examined how mangrove and mangrove-associated species were assembled in the functional trait space; General Linear Models (GLM) to compare mean trait values for each species among mangrove zones and Redundancy Analysis (RDA) to identify the interstitial water variables explaining functional composition. Laguncularia racemosa and Rhizophora mangle were mainly explained by SLA, LDMC and H; both species were associated to a bigger tree height, great leaf dry matter content, and small SLA values. GLM suggested ITV among mangrove zones with spatial patterns related to interstitial water variables. Our findings suggested mangrove species exhibited significant ITV mainly in SLA and H; salinity and pH were relevant to the functional ecology in mangrove ecosystems.
Simultaneously trapping solvents molecules and anions for stable and safe potassium-ion batteries
Authors: Yi Xianhui , Zhou Jiang , Lu Bingan 
Published: August 2022

Abstract
Critical issues along with potassium-ion batteries (PIBs) lies in free organic solvents molecules are always flammable, easily oxidized and will trigger the formation of potassium dendrite during cycling, leading to severe safety concerns and deteriorated cycle stability. Here, an environmental friendliness and facile preparation zeolitic imidazolate framework electrolyte, enabled by framework trapping strategy, is proposed to improve the performance of PIBs. The low cost electrolyte with simultaneously trapping strategy possesses high ionic conductivity, high oxidative stability (over 5.9 V), diverse inhibitory abilities - K dendrites, “shuttle effect”, and organic dissolution. Consequently, potassium metal symmetric battery shows a stable operation over 5,000 h at 0.1 mA cm−2, and graphite based potassium anode exhibits high capacity retention and high Coulombic efficiency. The high-voltage vanadium fluorophosphate (cycle in 2.0-4.6 V), easily soluble 3,4,9,10-perylenetetracarboxylic diimide (PTCDI) cathodes also can stable cycles more than 1,000 and 2,100 cycles, respectively. Moreover, the high energy density safe graphite||PTCDI based full cells exhibits an average capacity decay rate of 0.034% per cycle for 1,000 cycles at 50 mA g−1. This study presents a fresh approach for designing and developing low-cost and sustainable PIBs and beyond.
Modelling evolution of a large, critical glacier-fed lake in the Western Indian Himalaya
Authors: Gantayat Prateek , Ramsankaran RAAJ 
Published: August 2022

Abstract
In this study, we simulated the evolution of a large glacier-fed lake called the Gepangath lake located in Western Himalayas by numerically modelling the evolution of the Gepangath glacier that feeds the lake. This modelling was carried out by a 1D model that is based on the principle of mass conservation. The 1D model was forced with the glacier surface mass balance (SMB). Due to non-availability of published in-situ estimates, the SMB was estimated using an energy balance-based model on station derived and reanalysis derived meteorological data. Modelled glacier length fluctuations for over 134 years matched reasonably well with that of observed within the RMSE error ~320 m. In addition to that, between 2004 and 2019, the modelled and observed lake lengths were in agreement with each other with the RMSE ~110 m. Modelled glacier lake lengths also match well with published, satellite imagery derived lengths within 15% uncertainty. The obtained results though not highly accurate but demonstrate the importance of the combination of numerical models viz. ice-flow model and mass balance estimation model along with satellite images in modelling glacier lake evolution in the data-sparse Indian Himalayan Region (IHR). Such studies have the potential to help understand as well as predict the evolution of critical glacier-fed lakes in the IHR.
Association between clinical and surgical variables with postoperative outcomes in patients treated for intestinal obstruction for non-malignant conditions: a cross-sectional study
Authors: Girón Felipe , Chaves Carlos Eduardo Rey , Rodríguez Lina , Rueda-Esteban Roberto Javier , Núñez-Rocha Ricardo E. , Pedraza Juan Daniel , Conde Danny , Vanegas Marco , Nassar Ricardo , Hernández Juan David 
Published: August 2022

Abstract
Background: Intestinal obstruction is considered a frequent surgical pathology related to previous surgical procedures. Many different factors can lead to different outcomes when surgical management is needed. Therefore, we aim to describe the factors related to morbidity and mortality in surgical management of IO in a single-center experience.Methods: Retrospective observational study with a prospective database, in which we described patients who underwent surgical management due to intestinal obstruction between 2004 and 2015. Demographics, perioperative data, surgical outcomes, morbidity, and mortality were described. Results: 366 patients were included. Female were 54.6%. Mean age was 61.26. Laparoscopic approach was done in 21.8 % and the conversion rate was 17.2%. Intestinal resection was performed in 37.9% of the cases. Postoperative complications were observed in 18.85%. Reintervention and mortality were 9.5% and 4.1% respectively. Laparoscopic approach shows lesser time of intestinal transit (mean 28.67 vs mean 41.95 hours), and restart of oral intake after surgery (mean 96.06 vs mean 119.65) compared with open approach. Increased heart rate and intensive care unit length of stay were related with mortality (p 0.01 and 0.000 respectively). For morbidity, laparotomy and need and duration of ICU stay were related with any complication statistically significant (p 0.02, 0.008, 0.000 respectively).Conclusion: Patients with increased heart rate in the emergency room, decreased amount of intravenous fluids, need and higher length of stay in the intensive care unit, and delay in resuming oral intake after surgery appear to have poor outcomes. Laparoscopic approach seems to be a safe and feasible approach for intestinal obstruction.
Diurnal switching of physical activity reduces depression-related behaviors: A time-series analysis of wearable device data
Authors: YOKOYAMA Satoshi , KAGAWA Fumi , TAKAMURA Masahiro , TAKAGAKI Koki , KAMBARA Kohei , Mitsuyama Yuki , Shimizu Ayaka , OKADA Go , OKAMOTO Yasumasa 
Published: August 2022

Abstract
Background
Wearable devices have been widely used in research to understand the relationship between habitual physical activity and mental health in the real world. However, little attention has been paid to the temporal variability in continuous physical activity patterns measured by these devices. Therefore, we analyzed time-series patterns of physical activity intensity measured by a wearable device and investigated the relationship between its model parameters and depression-related behaviors.
Methods
Sixty-six healthy individuals used the wearable device for one week and then answered a questionnaire on depression-related behaviors. A seasonal autoregressive integral moving average (SARIMA) model was fitted to the individual-level device data and the best individual model parameters were estimated via a grid search.
Results
Out of 64 hyper-parameter combinations, 21 models were selected as optimal, and the models with a larger number of affiliations were found to have no seasonal autoregressive parameter. Conversely, about half of the optimal models indicated that physical activity on any given day fluctuated due to the previous day’s activity. In addition, both irregular rhythms in day-to-day activity and low-level of diurnal variability could lead to avoidant behavior patterns.
Conclusion
Automatic and objective physical activity data from wearable devices showed that diurnal switching of physical activity, as well as day-to-day rhythms, reduced depression-related behaviors. These time-series parameters may be useful for detecting behavioral issues that lie outside individuals’ subjective awareness.