bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biologically engineered microbes for bioremediation of electronic waste: Wayposts, challenges and future directions
Authors: Han Ping , Teo Wei Zhe , Yew Wen Shan 
Published: February 2022

AbstractIn the face of a burgeoning stream of e‐waste globally, e‐waste recycling becomes increasingly imperative, not only to mitigate the environmental and health risks it poses but also as an urban mining strategy for resource recovery of precious metals, rare Earth elements, and even plastics. As part of the continual efforts to develop greener alternatives to conventional approaches of e‐waste recycling, biologically assisted degradation of e‐waste offers a promising recourse by capitalising on certain microorganisms' innate ability to interact with metals or degrade plastics. By harnessing emerging genetic tools in synthetic biology, the evolution of novel or enhanced capabilities needed to advance bioremediation and resource recovery could be potentially accelerated by improving enzyme catalytic abilities, modifying substrate specificities, and increasing toxicity tolerance. Yet, the management of e‐waste presents formidable challenges due to its massive volume, high component complexity, and associated toxicity. Several limitations will need to be addressed before nascent laboratory‐scale achievements in bioremediation can be translated to viable industrial applications. Nonetheless, vested groups, involving both start‐up and established companies, have taken visionary steps towards deploying microbes for commercial implementation in e‐waste recycling.
H‐infinity fault‐tolerant control for Markov jump system with actuator time delay
Authors: Weng Falu , Hou Leilei , Wei Hui , Huang Yongji , Ding Yuanchun 
Published: February 2022

AbstractThis study investigates H‐infinity fault‐tolerant control for Markov jump systems with actuator time delay. The main objective is to obtain some theorems such that the corresponding Markov jump systems with actuator time delay to be H‐infinity stable and with some fault‐tolerant performances. First, based on an integral transformation, the Markov jump systems with actuator time delay are described in a system description with a distributed time‐delay item. Second, based on utilizing the linear matrix inequality theory, a positive energy functional, which includes a double integral item, is constructed. Then, after some mathematical operations, a sufficient condition is obtained for the Markov jump systems with actuator time delay to be H‐infinity stable. If the condition is solvable, fault‐tolerant controller can be gotten to guarantee the controlled system to be H‐infinity stable no matter there are some actuator faults existing in the system or not. Finally, examples are given to show the usefulness of the obtained theorem.
Visualization of the Third Ventricle, the Future Cavum Septi Pellucidi, and the Cavum Veli Interpositi at 11+3 to 13+6 Gestational Weeks on 3D Transvaginal Ultrasound Including Normative Data
Authors: Altmann Reinhard , Scharnreitner Iris , Auer Christian , Hirtler Lena , Springer Claudia , Falschlehner Stephanie , Arzt Wolfgang 
Published: February 2022

Abstract
Objectives To show the development of the third ventricle, commissural plate, future cavum septi pellucidi, and cavum veli interpositi in weeks 12–14 by transvaginal 3D ultrasound. Methods This is a prospective transvaginal 3D study carried out to define the third ventricle and the diencephalic midline structures surrounding it. 93 of 387 fetuses in which the commissural plate with the future cavum septi pellucidi, cavum veli interpositi, and the roof of the third ventricle could be well visualized, were selected with the choroid plexus of the third ventricle and the pituitary gland serving as leading structures. In a small number of fetuses, the optic chiasm could also be displayed. In addition, the following measurements were performed: third ventricle craniocaudal and anteroposterior, roof of the third ventricle/cavum veli interpositi, and fcsp. Results The sonomorphologic characteristics of the commissural plate, the future cavum septi pellucidi, and the cavum veli interpositi are described IN 9% OF THE FETUSES examined. Measurements of the third ventricle, cavum veli interpositi, and the roof of the third ventricle show the following results: 3rd V cc = 3.895 + 0.091*CRL mm; 3rd V ap = 4.175 + 0.036*CRL mm; CVI ap = 2.223 + 0.029*CRL mm; CVI cc = 0.139 + 0.02*CRL mm. Conclusion Transvaginal neurosonography enables visualization and measurement of the normal fetal third ventricle at 12–14 weeks of gestation including visualization of the future cavum septi pellucidi and the cavum veli interpositi. BEFORE USE IN PATIENTS CAN BE CONSIDERED, FURTHER SCIENTIFIC WORK IS REQUIRED.
Gründe und Einflussfaktoren für die Bereitschaft zur
Dokumentation von Präferenzen bezüglich Organspende. Ergebnisse
einer Online-Umfrage
Authors: Schildmann Jan , Nadolny Stephan , Führer Amand , Frese Thomas , Mau Wilfried , Meyer Gabriele , Richter Matthias , Steckelberg Anke , Mikolajczyk Rafael 
Published: February 2022

Zusammenfassung
Ziel der Studie Unterschiedliche Möglichkeiten zur Regelung der
Entscheidung über Organspende wurden im Vorfeld der parlamentarischen
Abstimmung am 16.01.2020 diskutiert. Das Ziel dieser Arbeit ist die Beschreibung
der Einstellungen der Bürger*innen zur Organspende und
Untersuchung der Prädiktoren für die (Dokumentation der)
Spendebereitschaft.
Methodik Querschnittserhebung via Onlinefragebogen in Berlin und
Sachsen-Anhalt im Zeitraum von 25.11.2019 bis 16.01.2020. Deskriptive Auswertung
und logistische Regressionsanalysen für den Einfluss von Alter,
Einkommen und Geschlecht auf Spendebereitschaft, Vorliegen eines
Spenderausweises sowie Faktenwissen.
Ergebnisse Es nahmen 676 von 20 020 eingeladenen
Bürger*innen (3,4%) an der Umfrage teil. Eine
Widerspruchslösung wurde von 54,9% (n=371)
befürwortet, wohingegen 49,4% (n=334) eine
Entscheidungslösung befürworteten. 63,3% waren
„bereit“ beziehungsweise „eher bereit“ ein Organ
zu spenden, 43,2% besaßen einen Organspendeausweis. Die
Organspendebereitschaft und die Wahrscheinlichkeit des Besitzes eines
Organspendeausweises nahmen mit zunehmendem Alter ab. Ein höherer
Bildungsstand war eher assoziiert mit dem Vorliegen eines Organspendeausweises.
Geschlecht, Einkommen, Bildungsstand und Faktenwissen zur Organspende waren
nicht mit der Spendebereitschaft assoziiert. 45,7% derjenigen mit
Spendebereitschaft aber ohne Ausweis hatten ihren Willen den Angehörigen
kommuniziert. Gründe für eine fehlende Dokumentation der
Organspendebereitschaft umfassen neben praktischen Aspekten auch
Befürchtungen bezüglich einer Festlegung sowie der medizinischen
Versorgung.
Diskussion Keine der diskutierten gesetzlichen Regelungen wird von einer
deutlichen Mehrheit der Antwortenden getragen. Differenzierte,
bevölkerungsbasierte Erhebungen können einen Ausgangspunkt
für die Entwicklung zielgruppenspezifischer Angebote zur
Erhöhung der Dokumentation des Willens bezüglich Organspende
nach Hirntod bilden.
Arzneimitteltherapiesicherheit bei ambulanten
Pflegediensten
Authors: Trutwin-Bornhöft Stephanie , Schumacher Julia , Döring Inge , Hennen Desirée 
Published: February 2022

Zusammenfassung
Einleitung Ältere Menschen sind aufgrund häufiger
Multimedikation besonders anfällig für unerwünschte
Arzneimittelwirkungen (UAW), welche die Hospitalisierungs- und
Mortalitätsrate erhöhen. Übernehmen speziell geschulte
Apotheker und Pflegefachkräfte mehr Verantwortung bei der Anwendung von
Arzneimitteln, können Risiken vermieden werden.
Methodik Es wurde eine auf Freiwilligkeit beruhende Befragung anhand eines
vorgegebenen Erhebungsbogens bei Pflegedienstleitungen von ambulanten
Pflegediensten (APD) durchgeführt sowie die gelagerten und gestellten
Arzneimittel untersucht.
Ergebnisse Bei 76% der untersuchten 104 APD wurden Arzneimittel
gelagert. In 63% der APD wurden dort vorrätige Arzneimittel
untersucht, in 55% fand ein Abgleich zwischen verordneten und gestellten
Arzneimitteln statt. Bei etwa der Hälfte der untersuchten Boxen und
Dosetts wurden Mängel festgestellt. Dabei wurden im Mittel pro
überprüfter Einheit 1,5 Fehler gefunden. 40% der
Pflegedienste lassen die Arzneimittel beim Transport zum Kunden 3 bis
6 h im Fahrzeug. Regelmäßige Besprechungen mit
Arztpraxen oder Apotheken führen weniger als 35% der APD durch.
Die Untersuchenden bewerteten bei 41 von 104 APD die Leistungen der
Pflegefachkräfte bei der Therapiebeobachtung positiv.
Schlussfolgerungen Therapiebeobachtung und Zusammenarbeit der APD mit
anderen Heilberuflern, v. a. mit Pharmazeuten, sollten verbessert
werden. Vor allem beim Stellen der Medikamente sollte mehr Sorgfalt und
Kontrolle (z. B. durch das Vier-Augen-Prinzip) erfolgen. In Zukunft
sollten weitere präzise durchgeführte und repräsentative
Erhebungen zu Medikationsprozessen in der ambulanten Pflege durchgeführt
werden. Analog zu bereits vorhandenen Untersuchungen zeigten sich Hinweise auf
Qualitäts- und Kommunikationsprobleme sowie Schwächen in der
Therapiebeobachtung bei APD. Fehlerquellen zeigten sich v. a. bei
Lagerung, Transport sowie beim patientenindividuellen Stellen. Aufgrund der
fehlenden Teilnahmeverpflichtungen sind die Ergebnisse der Untersuchung
limitiert.
Der Erfinder der „Triage“ – Dominique-Jean Larrey (1766–1842), Napoleons oberster Militärchirurg
Authors: Koehler Ulrich , Conradt Regina 
Published: February 2022

ZusammenfassungDominique-Jean Larrey (1766–1842) war leitender Chirurg der französischen Armee unter Kaiser Napoleon I. Er ist als Vater der modernen Militärchirurgie sowie der Entwicklung des „Triagesystems“ bekannt geworden. Larrey war ein hervorragender und engagierter Arzt, der nicht nur die eigenen, sondern auch die Soldaten der gegnerischen Truppen medizinisch versorgt hat. Beim Fehlen einer zuverlässigen Analgesie und Anästhesie war zu damaliger Zeit die Geschwindigkeit und das Können das hervorstechendste Merkmal eines Chirurgen. Gegen den Widerstand der Administration hat Larrey eine Erstversorgung auf dem Schlachtfeld sowie eine schnelle Bergung der Verwundeten mithilfe der „fliegenden Ambulanzen“ möglich gemacht. Er galt als großer Freund der Soldaten.
Efficacy of endoscopic ligation with O-ring closure for prevention of bleeding after gastric endoscopic submucosal dissection under antithrombotic therapy: a prospective observational study
Authors: Nishiyama Noriko , Kobara Hideki , Kobayashi Nobuya , Chiyo Taiga , Tada Naoya , Kozuka Kazuhiro , Matsui Takanori , Yachida Tatsuo , Fujihara Shintaro , Shi Tingting , Masaki Tsutomu 
Published: February 2022

Abstract
Background We examined the efficacy of a novel endoscopic ligation technique with O-ring closure (E-LOC) to prevent bleeding after gastric endoscopic submucosal dissection (ESD) under antithrombotic therapy.
Methods This single-center prospective study involved consecutive patients who were taking antithrombotic agents and underwent gastric ESD. E-LOC was performed by anchoring the nylon loop with hemoclips on both defect edges and/or the exposed muscle layer, and using O-ring band ligation around these deployed clips. The primary outcome was post-ESD bleeding rate. Secondary outcomes were complete closure rate, procedure time, sustained closure rate, and complications.
Results 48 patients were finally analyzed. The post-ESD bleeding rate was 0 %, the complete closure rate was 97.9 %, and the mean closure time was 29.9 minutes. The sustained closure rate was 95.8 % at postoperative day 2–3 and 33.3 % at postoperative day 10–11. No complications occurred.
Conclusion E-LOC may be an effective option for closing mucosal defects after gastric ESD under antithrombotic therapy. However, the preventive effect on post-ESD bleeding should be further investigated in high risk groups.
Association of Single-Nucleotide Polymorphisms of MAFB Gene with Nonsyndromic Cleft Lip with or without Cleft Palate in Kinh Vietnamese Patients
Authors: Phan Hoanh Duy Ba , Phuong Lam Hoai , Vu Hoang Anh 
Published: February 2022

Abstract
Background Cleft lip with or without palate (CL/P) is the most common orofacial birth defect. Single-nucleotide polymorphisms (SNPs) in MAFB gene (V-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog B) were identified as susceptible to this defect in a genome-wide association study. To further evaluate its role in this birth defect, we conducted this study with the aim of identifying allele frequencies, genotype frequencies, and association of SNPs rs13041247, rs6065259, and rs6072081 of MAFB gene with nonsyndromic cleft lip/palate (NCL/P) in Kinh Vietnamese patients.
Methods We performed case–control study involved 79 patients with NCL/P and 77 healthy controls. DNAs were extracted from participants' saliva and tetra-amplification refractory mutation system polymerase chain reaction (tetra-ARMS PCR) was used for genotyping SNPs.
Results SNPs of MAFB gene were genotyped using the Tetra-ARMS PCR method. We found that genotype CT of rs13041247 was associated with an increased risk of NCL/P in Kinh Vietnamese (odds ratioTCTT [ORTC/TT] = 1.63, 95% confidence interval [CI] = 0.83–3.19, p = 0.17). The G allele genotypes of SNP rs6072081 increase high risk for the malformation, statistically significant result (ORGG/AA = 7.06, 95% CI = 2.13–23.42, p < 0.001). There is no clear association between rs6065259 and CL/P (ORAA/GG = 0.75, 95% CI = 0.22–2.50, p = 0.32; ORAG/GG = 1.53, 95% CI = 0.79–2.97, p = 0.32). When the patients were divided into the phenotypic subgroups, there was a similar significant trend between the patients and controls for all SNPs.
Conclusions Our study provides further evidence of role of MAFB gene variations with NCL/P defect in Kinh Vietnamese.
Exposure of Skin Homografts from Related Living Donors to Radiotherapy and Its Effects on Acute Rejection and Wound Healing in Children with Deep Burns: A Randomized Controlled Trial
Authors: Megahed Mohammed Ahmed , Kashty Sherief Mohamed El , Nassar Ahmed Tharwat , Aboulfetouh Mohamed , AboShaban Mohammed Saad 
Published: February 2022

Abstract
Background The ideal skin substitute should be more similar to normal skin function while causing fewer reactions. The purpose of this study was to assess the effect of radiotherapy on minimizing acute rejection and enhancing wound healing in children with deep burns.
Patients and Methods A prospective randomized control study included 34 children admitted to the burn unit with deep burns under the age of 12 years. Through the tomotherapy device, a skin homograft from a related living donor was exposed to a local dose of radiotherapy of 500 centigray (cGy). It was immediately used for coverage of the prepared bed after the irradiation was completed.
Results The mean values of the laboratory parameters (ESR, CRP, IL-6, and TNF) for all burn patients in the study showed a significant difference, with p < 0.001. The mean ± standard deviation (SD) of the time from homograft coverage to the appearance of rejection was 9.62 ± 1.45 in group 1 and 14.35 ± 2.8 in group 2, with p < 0.001 (highly significant difference), indicating that exposure to radiotherapy can reduce graft rejection.
Conclusions The exposure of skin homografts from related living donors to a local low dose of radiotherapy can reduce a graft's ability to initiate inflammatory and immunological reactions, thereby minimizing rejection of a graft and enhancing epithelialization in children with deep second- and third-degree burns.
An Innovative Skin Simulation Model to Augment Competency-based Training in Facial Plastic Surgery
Authors: Tripathy Satyaswarup , Mohapatra Devi Prasad , Thiruvoth Friji Meethale , Sharma Ramesh Kumar , Reddy Likhitha , Thomas Neljo 
Published: February 2022

Abstract
Introduction Competency-based medical education (CBME) approach in the medical curriculum has been introduced globally with the goal of providing flexibility, accountability, and learner-centeredness among medical learners. Traditional surgical skill training in most places has relied on “see one, do one, teach one model,” while simulation model-based training has been shown to improve competencies in surgical trainees. We wanted to assess the usefulness of a hydrophilic barrier adhesive foam wound dressing as a novel skin simulation model for learning biomechanics and practice of cutaneous flaps among plastic surgical resident trainees at our institute.
Materials and Methods An absorbent, soft polyurethane foam pad located centrally upon a larger polyurethane membrane, coated with a hydrocolloid adhesive, forming an island dressing, was used as a simulation model for this study. It was obtained from the hospital store either after or nearing their expiry dates of clinical use. Plastic surgery residents in different years of training were invited to participate in a simulation workshop, using this novel model, and give their feedback.
Results Seventeen residents in different plastic surgery training levels participated in the workshop and gave their feedback on the skin flap simulation model. The simulation model received extremely high (100%) scores on two parameters, namely, utility for flap and suture practice and high scores (88%–94%) for texture, ability to mark, and improving confidence among trainees.
Conclusions Adhesive bilayer polyurethane foam can be used as a novel cutaneous skin flap simulation model for understanding the biomechanics of skin flaps and cutaneous flap practice.
Primary Prevention of Cancer-Related Lymphedema Using Preventive Lymphatic Surgery: Systematic Review and Meta-analysis
Authors: Ciudad Pedro , Escandón Joseph M. , Bustos Valeria P. , Manrique Oscar J. , Kaciulyte Juste 
Published: February 2022

AbstractBackground Several studies have proven prophylactic lymphovenous anastomosis (LVA) performed after lymphadenectomy can potentially reduce the risk of cancer-related lymphedema (CRL) without compromising the oncological treatment. We present a systematic review of the current evidence on the primary prevention of CRL using preventive lymphatic surgery (PLS).Patients and Methods A comprehensive search across PubMed, Cochrane-EBMR, Web of Science, Ovid Medline (R) and in-process, SCOPUS, and ScienceDirect was performed through December 2020. A meta-analysis with a random-effect method was accomplished.Results Twenty-four studies including 1547 patients fulfilled the inclusion criteria. Overall, 830 prophylactic LVA procedures were performed after oncological treatment, of which 61 developed lymphedema.The pooled cumulative rate of upper extremity lymphedema after axillary lymph node dissection (ALND) and PLS was 5.15% (95% CI, 2.9%–7.5%; p < 0.01). The pooled cumulative rate of lower extremity lymphedema after oncological surgical treatment and PLS was 6.66% (95% CI < 1–13.4%, p-value = 0.5). Pooled analysis showed that PLS reduced the incidence of upper and lower limb lymphedema after lymph node dissection by 18.7 per 100 patients treated (risk difference [RD] – 18.7%, 95% CI – 29.5% to – 7.9%; p < 0.001) and by 30.3 per 100 patients treated (RD – 30.3%, 95% CI – 46.5% to – 14%; p < 0.001), respectively, versus no prophylactic lymphatic reconstruction.Conclusions Low-quality studies and a high risk of bias halt the formulating of strong recommendations in favor of PLS, despite preliminary reports theoretically indicating that the inclusion of PLS may significantly decrease the incidence of CRL.
First Successful Separation of Craniopagus Twins in India—Plastic Surgical Considerations
Authors: Singhal Maneesh , Sabapathy Shanmuganathan Raja , Gupta Deepak , Mahapatra A. K. , Chauhan Shashank , Tiwari Raja , Venkatramani Hari , Kedia Shweta , Saha Shivangi , Sahu Shamendra Anand Anand , Dash Suvashis , Sodhi Megha 
Published: February 2022

AbstractSeparation of total vertical craniopagus with shared venous sinuses poses multiple challenges. Provision of soft-tissue cover to the exposed brains at the time of total separation is one of them, due to the large size of the defect and paucity of local tissues. Staged separation of twins is advised with partial venous and parenchymal disconnection in the first stage and total separation in the second stage. Tissue expanders are inserted in the first stage, and second stage planned to coincide with the period of adequate expansion. In the child being reported, emergency second stage was done due to the deteriorating general condition of the children. Left with inadequate expanded skin, the critical defect in a twin was managed with bilateral trapezius myocutaneous flaps. High ionotropic support of the postoperative period resulted in superficial necrosis of the flap, which was managed by debridement, allograft application and autograft later. Both twins had well-healed wounds by 3 months.
Barbie Doll Forehead: CAD Design from Silicon Block
Authors: Marwah Shruti , Handa Arjun 
Published: February 2022

AbstractThe forehead is an important determinant of masculine or feminine look of the face. There are many methods described to achieve forehead augmentation for a more feminine face, and they include fillers, autologous fat grafting, silicone implant or methyl methacrylate. We present a case of a “Barbie doll forehead,” which is an interesting trend in Asian countries. Availability of silicone implants of various sizes are not uniform and currently unavailable in India. Alternatively, we devised carved silicone block using computer-aided design (CAD). We also discuss the various methods described for forehead augmentation with their advantages and disadvantages.
Vascularized Ribs in the Treatment of Posterior Instrumentation Infection after Thoracic Vertebrectomy. Case Report
Authors: Cavadas Pedro C. , Baklinska Magdalena , Téllez Daniela 
Published: February 2022

AbstractIsolated vertebral mestastases can be successfully treated by surgical removal of the affected vertebral body and stabilization with alloplastic material. The bone union between the upper and lower vertebra is expected, yet a relatively high rate of a non-union has been reported. In case of infection, bone consolidation is altered, and removal of alloplastic material is recommended, which decreases spinal stability and is a devastating complication.This case report of delayed infection and exposure of posterior hardware after thoracic vertebrectomy without an interbody osseous union, authors present a successful treatment with vascularized rib flaps through an anterior approach followed by hardware removal.
Osseous Metaplasia of the Transverse Humeral Ligament in a 10-Year-Old Bengal Cat
Authors: Rodiño Tilve Verónica , Maddox Thomas , Ressel Lorenzo , Pettitt Rob 
Published: February 2022

AbstractThis report is of an osseous metaplasia of the transverse humeral ligament and secondary bicipital tenosynovitis in a 10-year-old Bengal cat. Computed tomography revealed the presence of an osseous bridge enclosing the bicipital groove, with ultrasonography confirming partial tear and inflammation of the bicipital tendon. Initial conservative management with intra-articular long-acting steroids failed to provide long-term improvement of clinical signs. Surgical excision of the osseous lesion resulted in complete resolution of lameness after surgery, confirmed by a 1-year follow-up. Histopathology of this lesion confirmed a well-differentiated osseous metaplasia of the transverse humeral ligament.
Endovascular Stent Graft Placement and Coil Embolization for Splenic Artery Aneurysm with an Anatomical Variant
Authors: Kuwada Noriaki , Akagi Daisuke , Watanabe Yoshiko , Kanaoka Yuji , Tanemoto Kazuo 
Published: February 2022

AbstractA 62-year-old woman with abdominal pain was diagnosed with a splenic artery aneurysm (SAA) and an anatomical variant in the splenic artery (SA) arising from the superior mesenteric artery (SMA) as its first branch. To treat the SAA, the draining artery and a small branch of the SAA were embolized, and then small-diameter stent grafts were deployed from SMA orifice, covering the aberrant origin of the SA and preserving the second branch of SMA. Intraoperative angiography confirmed successful exclusion of the SAA without endoleak or arterial dissection. The stent graft was patent and the aneurysm had shrunk 3.5 years after the operation.