bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, crystal structure, and properties of three lead(II) complexes based on the 1,10-phenanthroline ligand
Authors: Li De-Jun , Tang Shi-Li , Ma Feng-Jie , Zhang Lu-Lin , Cheng Yuan-Zheng , Zhang Li-Ping 
Published: August 2022

Abstract
Three new lead(II) complexes containing the 1,10-phenanthroline ligand, [Pb(phen)2(3,5-DNB)2] (1), [Pb(phen)2(3,5-DNB)(NO3)]2·H2O (2), and [Pb(phen)(HCOO)(NO3)(H2O)]
n
(3) (phen = 1,10-phenanthroline, 3,5-DNB = 3,5-dinitrobenzoate anion) have been synthesized and characterized by elemental analyses, Fourier transform infrared spectroscopy (FTIR), thermogravimetric analyses (TGA), and single-crystal X-ray diffraction. The complexes 1 and 2 are monomeric species, whereas complex 3 is a one-dimensional polymer. In the three complexes, the ligand phen creates a number of π···π stacking interactions and hydrogen bonds, which play an important role in extending complexes 1–3 to supramolecular architectures. The Pb(II) ion of complexes 1 and 2 shows hemidirected geometry with noncovalent Pb···O/C tetrel bonds formed which further stabilize the supramolecular structures.
L’écriture en crise pour un pays en crise. "Alger, journal intense" de Mustapha Benfodil
Authors: Brodziak Sylvie 
Published: August 2022

Depuis son roman Archéologie du chaos (amoureux) paru en 2007, Mustapha Benfodil s’applique à mettre en œuvre le programme énoncé par l’un de ses personnages : DECONSTRUIRE L’ORDRE NARRATIF NATIONAL. Son dernier roman, Alger, journal intense, publié en septembre 2019, en témoigne. Dans celui-ci comme dans tous ses textes, Benfodil fait exploser la langue, les genres, les formes discursives et éditoriales. Avec jubilation, colère et humour, il met à nouveau l’écriture en crise pour conter l’Algérie victime, depuis octobre 1988, d’une terrible série de crises. Ainsi, douze ans après, nous verrons comment, grâce à l’écriture déjantée de la fiction, Benfodil saisit le chaos historique dont l’Algérie post-coloniale essaie de sortir.
Determinants influencing use of lower tidal volumes, lower inspiratory pressures, and prone positioning in ARDS: A systematic review
Authors: Bass Geoffrey , Levy Elizabeth P. , Westover Julie E. , Ndebele-Ngwenya Phiwinhlanhla , Taichman Rebecca B. , Costa Deena Kelly , Weiss Curtis H. , Lane-Fall Meghan B. , Kerlin Meeta Prasad 
Published: August 2022

Abstract

Background:Lower tidal volumes and lower inspiratory pressures for patients with acute respiratory distress syndrome (ARDS) and prone positioning in severe ARDS are evidence-based practices that improve patient survival but are inconsistently applied. The objective of this systematic review is to identify what barriers, facilitators, and factors (together called determinants) influence the use of lower tidal volumes and lower inspiratory pressures for adult intensive care unit patients with ARDS and prone positioning for those with severe ARDS.Methods:We performed a systematic review employing PubMed, Embase, and CINAHL for studies published between January 1, 2000 and February 1, 2020. Studies reporting qualitative, quantitative, or mixed-methods data about determinants of implementation of the three strategies of interest were identified. We extracted determinants of implementation, study type, and evidence-based practice(s) studied. We assigned determinants to the Consolidated Framework for Implementation Research (CFIR) to organize contextual factors influencing implementation.Results:4,578 studies were screened and 32 manuscripts were included and analyzed. Lower tidal volumes was the most studied evidence-based practice (27 of 32 studies). 86 determinants were extracted. We assigned 62 (72%) of determinants to the CFIR, withCharacteristics of IndividualsandInner Settingmost represented. The other 24 (28%) determinants were related to the patient’s clinical condition and demographic factors. We assigned these to a domain developed through inductive reasoning, “Patient Factors,” with 15 (63%) assigned to the construct “Dynamic Patient Attributes” and 9 (38%) to “Static Patient Attributes.” 5 of 86 (6%) determinants related to prone positioning.Conclusions:Multiple determinants impact the delivery of lower tidal volumes and lower inspiratory pressures in patients with ARDS, but we identified few determinants for prone positioning in severe ARDS. Our application of implementation science theory enables clinicians to identify factors influencing this evidence-to-practice gap and may support investigations and interventions to improve guideline-concordant care in ARDS.Systematic Review Registration:We registered this systematic review on PROSPERO (PROSPERO 2019 CRD42019135160).
Transdermal delivery of diclofenac using various nano-drug delivery vehicles
Authors: Louw Estelle-Vionè , Liebenberg Wilna , Willers Clarissa , Dube Admire , Aucamp Marique E , Gerber Minja 
Published: August 2022

Abstract
Diclofenac (2-[(2,6-dichlorophenyl)amino]phenyl]acetic acid) was incorporated into different drug delivery vehicles to investigate the transdermal delivery thereof. These drug delivery vehicles included nano-emulsions, nano-emulgels and a colloidal suspension containing drug-loaded nanoparticles. The formulation of nano-emulsions and nano-emulgels was at different concentrations of evening primrose oil (EPO). The different drug delivery vehicles were compared in terms of the type of drug delivery vehicle and the concentration of EPO within the vehicle (if included).The characterization of the drug delivery vehicles and membrane release studies determined if the active pharmaceutical ingredient (API) was successfully released from the vehicle. Following this, in vitro skin diffusion studies and tape stripping (topical delivery) were conducted to establish whether the drug delivery vehicles assisted the API to successfully penetrate the skin and reach the target-site (transdermal delivery). By performing methyl thiazolyl tetrazolium (MTT) and neutral red (NR) assays on human keratinocyte (HaCaT) cells, the cytotoxicity of the drug delivery vehicles was investigated.Results from the membrane release and in vitro skin diffusion studies showed that the nano-emulsions and the 10% EPO drug delivery vehicles increased API release and diffusion when compared to the other drug delivery vehicles. However, the colloidal suspension had the highest concentrations of API within the stratum corneum-epidermis and the epidermis-dermis. The drug delivery vehicles showed minimal cytotoxic effects at concentrations equivalent to that which had permeated through the skin.
Lead absorption capacity in different parts of plants and its influencing factors: a systematic review and meta-analysis
Authors: jia lulu , Ma Hongkun , Guan Yue , Zou Lina , Jiang Lan , Hang Yongzheng , Feng Xiaoyan , Ren Xiaowei , Tian Yuting , Pan Hongzhi , Rong Shengzhong 
Published: August 2022

Abstract
People pose a serious risk by eating plants contaminated with lead in their soil. Lead enrichment in different parts of plant roots, stems, and leaves is controversial. Accordingly, a meta-analysis was conducted to investigate the ability of different plants to enrich lead and the main factors for lead absorption. The results of this study indicated that all parts of plants accumulated significantly lead. The concentrations of lead in different parts of root, stem and leaf were analyzed, and it was found that these concentrations followed an order of root > stem > leaf. Alkaline soil was beneficial to lead absorption by plants in this study. Significant differences were found in lead enrichment ability among vegetables, gramineae and trees. When the lead concentration in soil was higher than 20mg/kg, the lead absorption in different parts of roots, stems, and leaves was more. Lead is most absorbed in trees (e.g., ulmus pumila and murraya paniculate). It is the least in gramineae (e.g., rice, maize plants, and sweet sorghum). It is argued that this study is beneficial to select vegetables suitable for absorption of heavy metals from polluted soil. This study can help to clarify the ability of a variety of plant parts to enrich lead and the factors for lead enrichment in plants, so as to propose more reasonable lead pollution control strategies and guide people to make healthy choices when choosing edible plants.
Are primary care consultations in Trinidad patient-centered? A cross-sectional study of patients with non-communicable diseases
Authors: Rahaman Reisa R , Motilal M Shastri , Khan Raveed , Maharaj Rohan G 
Published: August 2022

Abstract
Background: The aim of this study was to measure the patient’s perception of patient centeredness in their consultations for non-communicable diseases (NCDs). We also measured consultation length and patient enablement.Method: A cross-sectional study was conducted over 2 months at four primary care clinics at the St. Joseph cluster of the North Central Regional Health Authority (NCRHA) in Trinidad and Tobago. Interviewers timed the consultation and completed post-consultation questionnaires using the Patient Perception of Patient-Centeredness (PPPC) questionnaire and the Patient Enablement Index (PEI). The PPPC is a 14-item (each scored 1-4) Likert-scaled instrument. The total score is averaged and a PPPC score of 4 is the maximum. The PEI measures the ability of the patient to cope with life and their disease. The PEI consists of 6 questions scored 0-2, with a maximum of 12. Results: There were 180 respondents (response rate = 82.5%). Participants were female (75.6%), aged over 65 years (50.6%), married (51.1%), Indo-Trinidadian (52.2 %), and Christian (60.6%). Half achieved a primary school education, and 37.2% secondary. The consultation length ranged between 1.32 and 31.22 minutes. The average, median and mode of the consultation length were 8.5, 7.74 and 10 minutes, respectively. The average, median and mode of the measures of patient-centeredness were PPPC (3.67, 3.86 and 4) and PEI score (5.93, 6 and 6). The PPPC average was lower in patients with a stroke (p=0.022), and higher among those with more than 2 consultation interruptions (p=0.015) and those who knew the doctor very well (p=0.015). The PEI score was lower in patients with heart disease (p=0.022). The consultation length was longer in those with tertiary education (p=0.044) and those with two consultation interruptions (p=0.032). PPPC Average and PEI Score correlated well (ρ = 0.408, p<0.001). The consultation length correlated with the PPPC Average (ρ=0.168, p=0.025) . Conclusion: Primary Care consultations in this cluster of health centres in NCRHA in Trinidad were often patient centered. The consultation length, patient-centeredness, measured with the PPPC instrument, and patient enablement scores, measured with the PEI instrument, in consultations for NCDs in Trinidad compare favourably with international reports.
Evaluating and comparing critical thinking skills of specialty residents of Tehran University of Medical Sciences
Authors: Mehrpour Saeed Reza , Shavoun Amin Hoseini , Kheiltash Azita , Masoomi Rasoul , Seraji Roya Nasle 
Published: August 2022

Abstract
Background
Today’s complexities and diversity in the clinical setting have revealed the need to pay attention to strengthening critical thinking skills. The present study aimed to evaluate and compare critical thinking skills in the specialty residents of Tehran University of Medical Sciences.
Methods
The present study is a descriptive and cross-sectional type of study. The statistical population of the study included 284 specialty residents in orthopedic, internal medicine, and surgery groups studying in the first to fourth years of residency. They were selected by a census method. A two-section questionnaire, including demographic characteristics and the California Critical Thinking Skills Test -Form B (CCTST-B), was used to collect data. The collected data were entered into SPSS-16 software and analyzed using descriptive (mean and standard deviation) and inferential (one-way ANOVA) statistics. The significant level in all tests was considered at P < 0.05.
Results
The mean critical thinking skill score of specialty residents (SD = 3.52, M = 13.81) was found at a level lower than the optimal level. A significant difference was found between the critical thinking skill scores in the three groups (internal medicine, surgery, and orthopedic). Comparing the mean critical thinking skill scores of the specialty residents separately for residency year revealed a significant difference between critical thinking skill scores in the four groups.
Conclusion
The critical thinking skills of the specialty residents of Tehran University of Medical Sciences were generally below the optimal level. The critical thinking score of the residents increased in the second year, but it was reduced again in the third and fourth years. Due to the emphasis of accreditation institutions, the World Federation for Medical Education, and other international institutions on the promotion of critical thinking, it is recommended to pay more attention to the factors related to the promotion and development of critical thinking skills in specialty residents.
Associations of depression status and grade point average for female undergraduate
Authors: Qi Yanbo , Hou Qingzhi 
Published: August 2022

Abstract
Background: Undergraduate mental health was one of important contents for university and college implement overall education for all-round development. We aimed to explore the association between mental health and the grade point average (GPA) for freshman. Methods: There were 930 freshman whose average age was 17.97±0.68 years old. SAS (Self-Rating Anxiety Scale), SDS (Self-Rating Depression Scale), SCL-90 (Self-reporting Inventory), and IRIDS (Interpersonal Relationship Integrative Diagnostic Scale) were used to assessed the undergraduate mental health in our present study. Logistic regression and Generalized Linear Regression Model (GLM) and Restricted Cubic Splines function (RCS) model were used to explore the mental health and GPA for freshmen.Results: The grade point average in female freshman was higher than male (3.06±0.52 vs 2.77±0.55, P<0.001), and SDS score was higher than male freshman (44.88±11.30 vs 42.43±9.93, P=0.005). After adjusting for age and departments, higher SDS score was associated with the risk of lower grade point average risk (OR=1.41, 95%CI: 1.14, 1.75, P=0.001) for female students. In liner analyses, the SDS score had a negative association with grade point average (β=-0.01, 95%CI: -0.098, -0.001, P=0.002) for female students, and there was Conclusions: The SDS score for female undergraduate was higher than male, and the SDS score was negatively associated with grade point average for female undergraduate.
N6-methyladenosine modification of RanGAP1 promotes colorectal cancer progression via CRABP2
Authors: Yang Cheng , Li Junqiang , Shi Jingjie , Guo Yongdong , Sun Xin , Gan Dongxue , Wang Ronglin , Zhu Liaoliao , Ma Peixiang , Hua Lei , Yang Rui , Min Jie , Zhao Ting , Li Shanshan , Song Yang , Su Haichuan 
Published: August 2022

AbstractRan GTPase activating protein 1 (RanGAP1) plays an important role in a variety of diseases; however, whether it affects colorectal cancer progression(COAD) is unclear. In this study, RanGAP1 was identified as a novel downstream gene of METTL3 in COAD by m6A epitranscriptomic microarray, MeRIP-seq and label-free proteomics analyses. RIP-qPCR and Luciferase reporter explored the molecular mechanism of m6A modifition. RNA-seq and label-free proteomics determined CRABP2 is a downstream target of RanGAP1. In vitro/vivo experiment verified the function upon RanGAP1 and CRABP2 silencing/overexpressing. The results showed RanGAP1 was highly expressed in COAD and CRABP2 was found to be positively correlated with RanGAP1. In addition, silencing RanGAP1/CRABP2 inhibited the tumorigenesis of COAD, while overexpressed RanGAP1 recused the influence of METTL3 sliencing in the malignant phenotype. Meanwhile, RanGAP1 affected the sensitivity of oxaliplatin and fluorouracil to COAD. Mechanistically, there is the direct interaction between METTL3/YTHDF1 and RanGAP1, and METTL3 mediates m6A methylation in the 3′UTR region of RanGAP1 mRNA and affects mRNA stability by recruiting YTHDF1. These results revealed RanGAP1 was a new downstream mechanism of METTL3-mediated m6A modification and promote COAD progression via CRABP2, which maybe is a potential therapeutic target for COAD.
Providing an Approach For Early Prediction of Fall in Human Activities Based on Wearable Sensor Data and The Use of Deep Learning Algorithms
Authors: Hatkeposhti Rahman Keramati , YadollahzadehTabari Meisam , GolsorkhTabariAmiri Mehdi 
Published: August 2022

Abstract

Fall is an inevitable part of people's lives, and its early prediction and diagnosis is significant for maintaining physical and mental health. This study aims to identify and make early predictions of impending falls based on wearable sensor data. The proposed approach considered a prediction timeslice (T) parameter. The system can view the labeling up to that time interval, and instead of labeling the current moment state, the T seconds later states are considered. The Sisfall dataset was used in this study, and two deep learning models of the convolutional neural network (CNN) and a hybrid model called Conv-Lstm were implemented on this dataset. This study also offers a dynamic sampling technique for increasing the balance rate between the samples belonging to fall and normal classes to improve the accuracy of the learning algorithms. Based on the evaluation results, the Conv-Lstm hybrid model performed better and was able to have a forecast with an accuracy of 78% and an average time of 0.34 seconds earlier than the accident in the prediction timeslice of 1 second. Also, This model has been able to provide the best result in predicting the fall in the average Sensitivity criterion with 95.18% and in the Accuracy criterion with 97.01%. In addition, a post-processing technique has been used using a median filter algorithm, which improved the accuracy of the fall prediction by up to 95%.
Targeting the tumor immune microenvironment could become a potential therapeutic modality for aggressive pituitary adenoma
Authors: Yang Zuocheng , Tian Xueling , Yao Kun , Yang Yakun , Zhang Linpeng , Liu Ning , Yan Changxiang , Han Song , Qi Xueling 
Published: August 2022

Abstract
Purpose
This study aimed to explore the relationship between the aggressiveness and immune cell infiltration in pituitary adenoma (PA) and provide the basis for immuno-targeting therapies.
Methods
One hundred three patients with PA who underwent surgery at a single institution were retrospectively identified. The infiltration of macrophages and T-lymphocytes was quantitatively assessed.
Results
The number of CD68 + macrophages was positively correlated with Knosp (P = 0.003) and MMP-9 expression grades (P = 0.00). The infiltration of CD163 + macrophages differed among Knosp (P = 0.022) and MMP-9 grades (P = 0.04). CD8 + tumor-infiltrating lymphocytes (TILs) were also positively associated with Knosp (P = 0.002) and MMP-9 grades (P = 0.01). Interestingly, MGMT expression was positively correlated with MMP-9 staining extent (P = 0.000). The quantities of CD8 + TILs (P = 0.016), CD68 + macrophages (P = 0.000), and CD163 + macrophages (P = 0.043) were negatively associated with MGMT expression levels. The number of CD68 + macrophages in the PD-L1 negative group was significantly more than that in the PD-L1 positive group (P = 0.01). The rate of PD-L1 positivity was positively correlated with the Ki-67 index (P = 0.046) and p53 expression (P = 0.029).
Conclusion
Targeted therapy for macrophages and CD8 + TILs could be a helpful treatment in the future for aggressive PA. Temozolomide (TMZ) may have better effects on the treatment of PAs with greater immune cell infiltration. Anti-PD-L1 therapy may better respond to PAs with higher Ki-67 and p53 expression and more infiltrating CD68 + macrophages. Multiple treatment modalities, especially combined immunotherapy, or combination immunotherapy with TMZ, could become a novel therapeutic strategy for aggressive PA.
Superradiance in alpha clustered mirror nuclei
Authors: Volya Alexander , Barbui Marina , Goldberg Vladilen , Rogachev Grigory 
Published: August 2022

Abstract
Resonances in unstable quantum systems are radiating states that despite decaying overall normalization have a well-defined structure which is being balanced by outgoing radiation.
Such an interplay between outgoing wave and internal quantum many-body dynamics leads to several unique effects. One of those is known as superradiance, or alignment, where due to decay or virtual
coupling to the continuum the states undergo restructuring so that their wave functions align towards the decay channels thus facilitating the decay. This effect is well understood theoretically and is closely related to the fundamental properties of reaction physics.
Direct observation of superradiance in open quantum many-body systems is difficult because it is hard to find identical complex quantum systems that are different only in their coupling to the continuum of reaction states describing the decay. Here we report the first observation of this phenomenon in alpha cluster decays of mirror nuclei 18O and 18Ne.
Resizing the extension of the mesophotic “reefs” in the Brazilian Equatorial Margin using bioclastic facies and seabed morphology.
Authors: Filho João Regis dos Santos , Anjos João Victor Moraes , Silva Cleverson Guizan , Filho Allan Kardec Duailibe Barros , Dias Gilberto Tavares Macedo , Figueiredo Alberto Garcia , Cecilio Amanda Bourguignon 
Published: August 2022

Abstract
Mesophotic reefs are rigid-bottom structures that compose an essential ecological role in the marine environment, but their knowledge is scarce compared to the shallow reefs due to diving depth limits and the high cost of geological and geophysical surveys deep ward. The uncovering of an extensive Amazon mesophotic reef system, or Great Amazon Reef System (GARS), in parallel to the discoveries of expressive oil and gas reservoirs in this region, became an essential discussion about marine heritage protection and mineral resource exploitation. Based on an unprecedented dataset reunion (962,338 depth points, 5,515 sampling stations and 384 seismic reflection lines), this paper presented a more accurate and realistic mapping of the mesophotic reefs over the Brazilian Equatorial Margin continental shelf. With an area of 13,478km², the carbonate facies (Bioclastic gravels) represented only 4,2% of the shelf. The results indicate that the GARS, a much smaller area than previously predicted, would correspond to a small portion of a Great Brazilian Mesophotic Bioconstruction Province (GBMBP).
Mathematical Analysis for Performance Evaluation of Beamforming Technique using SIR
Authors: Vasquez-Toledo Luis Alberto , Tirado-Mendez Jose Alfredo , Pascoe-Chalke Michael , Marcelin-Jiménez Ricardo , Rodríguez-Colina Enrique 
Published: August 2022

Abstract
In this paper, three scenarios for cellular communications are analyzed and compared, taking into account the Signal-to-Interference Ratio (SIR), and Average Data Rate. The analysis involves the coverage analysis that includes the derivation of the mathematical expressions for the coverage user probability distribution, the SIR and the transmission rate. The three scenarios are: universal reuse, sectorization by cell and cell sectorization with Beamforming. Results show that Beamforming out-performs the others, presenting an increment in the average SIR up to 10 dB. Also, it offers an improvement in Data Rate which is 27% better in the ring 1, 113% better in the ring 2 and 700% better in the ring 3.