bluuebunny/crossref_metadata_2025_split huggingface dataset:
HP 2-2 genotype Predicts Rapid Disease Progression in Nondialysis Patients and Mortality among South Indian ESRD Patients
Authors: Vasudevan Varadaraj , Ramprasath Tharmarajan , Sampathkumar Krishnaswamy , Puhari Shanavas Syed Mohamed , Yuvaraj Subramani , Selvam Govindan Sadasivam 
Published: April 2022

Abstract
Objectives
Haptoglobin (HP), a plasma glycoprotein, binds to free hemoglobin and prevents the loss of iron and kidney damage. In a prospective study, we determined whether HP variants (HP 1–1, HP 2 − 1, HP 2–2) are associated with chronic kidney disease (CKD).
Design & Methods
: From the Southern part of India, 392 CKD patients (nondialysis, ND; n = 170, end stage renal disease, ESRD; n = 222) and 202 healthy individuals were enrolled, and followed up for up to 70 months. The patients' blood samples were used for determining biochemical parameters and HP genotyping. Gene frequency and biochemical parameters were statistically analyzed for disease association.
Results
Higher HP 2–2 genotype frequency showed an increased hazard ratio for overall disease progression among ND patients (hazard ratio = 3.86; 95% CI = 1.88 to 7.93; P = 0.0002). Survival analysis also showed that Non HP 2–2 patients have a statistically significantly decreased risk for mortality compared to patients with the HP 2–2 genotype (ESRD patients hazard ratio = 4.05; P = 0.04). Thus, our data confirm that HP 2–2 polymorphism was statistically associated with the risk for all-cause rapid disease progression in CKD patients.
Conclusions
Concluding our results, HP 2–2 genotype could be an independent predictor of all-cause mortality in patients with CKD.
Nomogram for predicting rebleeding after initial endoscopic epinephrine injection monotherapy hemostasis in patients with peptic ulcer bleeding: a retrospective cohort study
Authors: He Shan , Liu Linlin , Ouyang Liu , Wang Jingsong , Lv Nonghua , Chen Youxiang , Shu Xu , Zhu Zhenhua 
Published: April 2022

Abstract
Background: Although the current guidelines recommend endoscopic combination therapy, endoscopic epinephrine injection (EI) monotherapy is still a simple, common and effective modality for treating peptic ulcer bleeding (PUB). However, identifying rebleeding patients after EI monotherapy is unclear, which is highly important in clinical practice. This study aimed to identify risk factors and constructed a predictive nomogram related to rebleeding after EI monotherapy.Methods: We consecutively and retrospectively analyzed 360 PUB patients who underwent EI monotherapy between March 2014 and July 2021 in our center. Then we identified independent risk factors associated with rebleeding after initial endoscopic EI monotherapy by multivariate logistic regression. A predictive nomogram was developed and validated based on the above predictors.Results: Among all PUB patients enrolled, 51 (14.2%) had recurrent hemorrhage within 30 days after endoscopic EI monotherapy. After multivariate logistic regression, shock [odds ratio (OR) = 12.691, 95% confidence interval (CI): 5.129-31.399, p < 0.001], Rockall score (OR=1.877, 95% CI: 1.250-2.820, p =0.002), tachycardia (heart rate>100 beats/min) (OR=2.610, 95% CI: 1.098-6.203, p =0.030), prolonged prothrombin time (PT>13 s) (OR=2.387, 95% CI: 1.019-5.588, p =0.045) and gastric ulcer (OR=2.258, 95% CI: 1.003-5.084, p =0.049) were associated with an increased risk of rebleeding after an initial EI monotherapy treatment. A nomogram incorporating these independent high-risk factors showed good discrimination, with an area under the receiver operating characteristic curve (AUROC) of 0.876 (95% CI: 0.817–0.934) (p<0.001).Conclusions: We developed a predictive nomogram of rebleeding after EI monotherapy, which had excellent prediction accuracy. This predictive nomogram can be conveniently used to identify low-risk rebleeding patients after EI monotherapy, allowing for decision-making in a clinical setting.
Factors affecting condom-use behaviors among emerging adults in South Korea
Authors: Lee Jungmin , Ross Ratchneewan 
Published: April 2022

Abstract
Purpose: To date, no studies have examined the association between gender-driven power dynamics and the decision-making process for condom use in South Korea. This study aimed to identify predictors of condom-use behaviors among female emerging adults in South Korea. Participants and methods: A cross-sectional survey was conducted using social network services, and the participants comprised 169 female college students aged 18‒25 years who were actively engaging in sexual intercourse. Results: The results showed that attitudes toward condom use was a stronger predictor of condom-use behaviors than sexual double standards. A significant implication of this study is the need for novel approaches to address condom use in female emerging adults. Potential approaches should consider gender dynamics and have cultural and social relevance for South Korean society. Conclusion: The current findings offer insight into developing future interventions tailored to the population to promote condom use, thereby preventing STDs/HIV, unwanted pregnancies, abortions, and other negative consequences in female emerging adults in South Korea.
Sutureless versus purse string with complete sac dissection in Laparoscopic inguinal hernia repair in children: A randomized clinical trial
Authors: Elsayem Karam , Abdelmotaal Yehia S , Kaddah Sherif , Elbarbary Mohammed M , Taher Heba 
Published: April 2022

Abstract
Introduction: Pediatric inguinal hernia is a common surgical problem with cumulative incidence of 4.2%. Minimal invasive surgery role is growing in the treatment of this problem. We compared the outcome of laparoscopic sutureless herniotomy and purse string with sac dissection repair regarding complications and operative time. Methods: one hundred fifty two patients were operated in two centers with two different techniques: Sac dissection and purse string suture and sutureless repair. Operative time and recurrence were the main outcomes of comparison. Results: Sutureless repair has shorter operative time (29±10 minutes) compared to purse string repair (38±13 minutes). The recurrence rate showed no statistical significance difference. However, the recurrence rate of Sutureless repair was three folds higher than the purse string repair and all recurrences were in large defects of 10-15 mm. Conclusion: Sutureless repair is safe for defects up to 10 mm with excellent operative time. However, it had an unfavorable outcome in larger defects. Research and ethical committee approval number: D-11-2020
Abnormal Cortical Thickness and Structural Covariance Networks in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations
Authors: Li Shu , Bai Ru , Yang Yifan , Zhao Ruotong , Upreti Bibhuti , Wang Xiangyu , Liu Shuang , Cheng Yuqi , Xu Jian 
Published: April 2022

Abstract
Background
Non-neuropsychiatric systemic lupus erythematosus (non-NPSLE) has been confirmed to have subtle changes in brain structure before the appearance of obvious neuropsychiatric symptoms. Previous literature mainly focuses on brain structure loss in non-NPSLE; however, the results are heterogeneous, and the impact of structural changes on the topological structure of patients' brain network remains to be determined. In this study, we combined neuroimaging and network analysis methods to evaluate the changes in cortical thickness and its structural covariance networks (SCNs) in patients with non-NPSLE.
Methods
We compare the cortical thickness of non-NPSLE patients (N = 108) and healthy controls (HCs, N = 88) using both surface-based morphometry (SBM) and regions of interest (ROIs) method, respectively. After that, we analyzed the correlation between the abnormal cortical thickness results found in the ROIs method and a series of clinical features. Finally, we constructed the SCNs of two groups using the regional cortical thickness, and analyzed the abnormal SCNs of non-NPSLE.
Results
By SBM method, we found that cortical thickness of 34 clusters in the non-NPSLE group was thinner than that in the HCs group. ROIs method based on Destrieux altas showed that cortical thickness of 57 regions in the non-NPSLE group was thinner than that in the HCs group and related to the course of disease, autoantibodies, the cumulative amount of immunosuppressive agents, and cognitive psychological scale. In the SCNs analysis, the cortical thickness SCNs of the non-NPSLE group did not follow the small-world attribute at a few densities, and the global clustering coefficient appeared to increase. The area under the curve analysis showed that there were significant differences between the two groups in clustering coefficient, degree, betweenness, and local efficiency. There are a total of seven hubs for non-NPSLE, and five hubs in HCs, the two groups do not share a common hub distribution.
Conclusion
Extensive and obvious reduction in cortical thickness and abnormal topological organization of SCNs are observed in non-NPSLE patients. The observed abnormalities may not only be the realization of brain damage caused by the disease, but also the contribution of the compensatory changes within the nervous system.
The Establishment and Validation of Reference Intervals for Plasma Pentraxin-3 in Healthy Volunteers and Patients with Takayasu's Arteritis
Authors: Zhou Xiang , Han Qing , Wang Xiqing , Zhang Ming , Li Xiang , Ma Wenhui , Wang Xueying , Yang Weidong , Zhu Ping , Wang Jing , Kang Fei 
Published: April 2022

Abstract
Objective
To establish reference intervals (RIs) for PTX-3 and to validate the performance of these RIs in a population including healthy volunteers and Takayasu's arteritis (TAK) patients.
Methods
Enzyme-linked immunosorbent assays were used to determine the plasma PTX-3 levels of 166 healthy volunteers and 63 TAK patients. RIs were established in healthy volunteers according to guidelines from the Clinical and Laboratory Standards Institute (CLSI, C28-A3). Global assessment was used to quantitatively diagnose active/non-active TAK patients. PTX-3 cut-off values and RI-derived values were calculated as candidate standards for quantitative diagnosis. Screening and monitoring performances were validated by identifying active TAK patients from the whole population or diagnosed TAK patients. Traditional inflammatory markers C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were included in the comparison.
Results
PTX-3 level increased with age but were not significantly different among different age or gender groups (p > 0.05). The PTX-3 RI was calculated to be 0.87–2.78 ng/mL (RI median: 1.66 ng/mL). For screening purposes, the cut-off value (1.55 ng/mL) had a high sensitivity of 90.32% and the RI upper limit (2.78 ng/mL) had a high specificity of 97.94%. For monitoring purposes, the sensitivity/specificity of the cut-off value (1.55 ng/mL) and RI median were 90.32%/90.63% and 80.85%/90.63%, respectively. These screening and monitoring performances of PTX-3 were superior to those of CRP and ESR.
Conclusion
The distribution of serum PTX-3 levels was stable and uniform across the population. The screening and monitoring performances of the cut-off value and RI-derived values of PTX-3 were higher than CRP and ESR.
Aberrant expression of JAM2 inhibits invasion and migration in lung adenocarcinoma
Authors: cui yuan , Xie Zhuolin , Chen Jun , Li Chang , Ju Sheng , Ding Cheng , Xu Chun , Tong Xin , Zhao Jun 
Published: April 2022

Abstract
Purpose: lung adenocarcinoma (LUAD) is the most prevalent histologic subtype in lung cancer. As a number of Junctional adhesion molecule (JAM) family, JAM2 involves in multiple functions, such as cell-cell contacts, as well as tumor development. Different expression profiles and roles of JAM2 have also been studied in various cancers. However, the clinical and biological significance of JAM2 in LUAD has not been fully illuminated. Methods: Four gene expression profiles were downloaded from the Gene Expression Omnibus database (GEO) to identify differentially expressed genes (DEGs) between LUAD and normal tissure. Then, GEPIA was employed to unveil expression level and prognosis value of JAM2 in LUAD. Enrichment analyses were performed among coexpression genes in different JAM2 subgroups. Moreover, a protein-protein interaction (PPI) network of the coexpression genes was constructed, and hub genes were explored with Cytoscape software. The expression of JAM2 was verified in LUAD cell lines, wound-healing assays and transwell assays were used to identify cell migration and invasion abilities.Results: we confirmed that JAM2 was downregulated in LUAD, which may be the result of methylation. JAM2 could be served as an independent prognostic gene to predict the outcomes of LUAD patients. It played a broad role in LUAD inflammatory infiltration and higher JAM2 expression may predict a better immunotherapy response. What’s more，we found migratory and invasive capabilities of LUAD cells were significantly suppressed when JAM2 was overexpressed. Conclusion: According to the findings, JAM2 may be a promising molecular target for early diagnose and targeted therapy of LUAD.
Impact of chemotherapy resumption on the outcome of Staphylococcus aureus bacteremia in patients with solid tumors
Authors: Edagawa Shunji , Naito Tateaki , Yamamoto Shuhei , Terada Norihiko , Nakaya Yuichiro , Mori Keita , Kurai Hanako 
Published: April 2022

Abstract
Purpose
Staphylococcus aureus bacteremia (SAB) is a common infection in patients with solid tumors undergoing chemotherapy. In medical oncology, this dilemma often arises between infection control and cancer treatment. We aimed to explore whether early resumption of chemotherapy yielded unfavorable outcomes in oncologic patients with SAB.
Methods
We retrospectively reviewed patients who received antineoplastic chemotherapy within 90 days of SAB onset. We divided patients who resumed chemotherapy into early and late resumption groups and investigated whether chemotherapy after SAB was associated with treatment failure. Treatment failure included recurrence or relapse, 90-day all-cause mortality after initiation of antibiotics toward susceptible microorganisms, and 30-day all-cause mortality after resumption of chemotherapy.
Results
Among the 78 eligible patients, catheter-related bloodstream infection was the most common (51 patients, 65.4%). Thirty-six patients (46.2%) resumed chemotherapy under the supervision of infectious disease specialists. The median interval from the date of negative blood culture to the date of chemotherapy resumption was 17.5 days (0–69). Two patients in the early resumption group (\(<\)17.5 days, 11.1%) and one in the late resumption group (\(\ge\) 17.5 days, 5.6%) died within 90 days after the initiation of antibiotics toward susceptible microorganisms. One patient (5.6%) in the early resumption group experienced SAB recurrence. None of the patients experienced SAB relapse or died within 30 days of resuming chemotherapy.
Conclusion
Early resumption of chemotherapy may not be directly associated with unfavorable outcomes in SAB in patients with solid tumors under appropriate infection management.
Biosorption of lead by a soil isolate Aspergillus neoalliaceus
Authors: Aracagök Y. Doruk 
Published: April 2022

Abstract
This study focused on Pb (II) elimination from aqueous solutions using fungal soil isolate which is identified as Aspergillus neoalliaceus. The sorption of lead with fungal mass studies was performed as a function of pH, biomass dose, contact time, and initial dye concentration. The solution pH value strongly affected the sorption of lead fungal mass. To examine the effect of hydrogen ions on biosorption in solutions containing lead, solutions with different pH values were used and pH 5 was found to be the most suitable pH value for lead removal. Lead biosorption was remained very low below pH 4 because of the competing effect of hydrogen ions in solution. It has been observed that the removal of lead ions based on biosorption with Aspergillus neoalliaceus is better explained by Langmuir isotherm and pseudo-second-order kinetic models compared to other used models.
Meta-Analysis of the efficacy of DPMAS-based artificial liver in the treatment of ACLF
Authors: Ma Lina , Zhang Xu , Ma Wanlong , Ding Xiangchun 
Published: April 2022

Abstract

Background & Aim: Many references have reported the feasibility of various artificial liver support systems in the treatment of acute-on-chronic liver failure caused by Hepatitis B. However, there is still controversy over their efficacy, safety, and impact on survival rates. Meta-analysis was conducted to assess the efficacy, safety, adverse reactions, and survival rate of hepatitis B-caused ACLF treated with artificial liver support systems based on the double plasma molecular absorption system (DPMAS). Methods: The keywords or abstractions “liver failure, severe hepatitis, acute-on-chronic liver failure” were searched on the databases such as CBM, PubMed, Cochrane library, etc. and the Revman5.3 software was used to analyze the literature data. Results: After analysis, DPMAS improved total bilirubin and 90-day survival rate higher than plasma exchange (PE). However, there was no statistical significance in international standardized ratio (INR). the results of international normalized ratio (INR) were [MD=0.06, 95% CI (-0.38, 0.49), P>0.05], that of 90-day survival rate were [OR=3.07, 95% CI (1.87, 5.02), P<0.05]. The improvement of total bilirubin (TBIL), albumin (ALB), alanine aminotransferase (ALT), the adverse reactions, the 90-day survival rate and the improvement rate after treatment all were better in DPMAS+PE than PE. However, there were no statistical significance in prothrombin activity (PTA), prothrombin time (PT),blood platelet (PLT), international standardized ratio (INR), hemoglobin (HB), and creatinine (Cr). Conclusion: Total bilirubin are reduced more in DPMAS than in PE after treatment, which might be related with the special bilirubin adsorption column (BS330II) in DPMAS. Whereas, the improvement in INR was not significant in DPMAS compared to PE, which may require additional investigation. The combination of DPMAS and PE reduced total bilirubin more effectively. Furthermore, while they were able to boost ALB, there was no difference in coagulation function, owing to the fact that PE could supply the proteins and coagulation components required by the human body. This meta-analysis also demonstrated that DPMAS+PE reduced the incidence of adverse reactions, increased the effective rate following treatment, and improved 90-day survival rate. Perhaps it's because DPMAS reduces the use of plasma products and removes more toxic substances like bilirubin and inflammatory agents
Peptic ulcer: the current state of the problem
Authors: Maev I. V. , Andreev D. N. , Samsonov A. A. , Cheryomushkina A. S. 
Published: April 2022

Peptic ulcer disease (PUD) is a chronic polyetiological recurrent disease of gastroduodenal region. In most cases, the pathogenesis of PU is caused by imbalance between the aggressive factors and protective factors of the gastric or duodenal mucosa. Helicobacter pylori (H. pylori) infection and the use of non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, are the major causative factors leading to PUD development. 65% of gastric ulcers and 80% of duodenal ulcers were found to be associated with H. pylori infection. In turn, NSAIDs account for 30% of gastric ulcers and 15% of duodenal ulcers. About 0.1–1% of all PUs are caused by Zollinger-Ellison syndrome. Abdominal pain is the leading symptom in the clinical findings of patients with exacerbation of PUD. Dyspeptic syndrome (vomiting, nausea, belching, abnormal bowel pattern) is much less common in patients with PUD. Endoscopic examination of the upper gastrointestinal tract is currently the gold standard test used in the diagnosis of PUD and is recommended for all patients suspected of having this disease (unless contraindicated). Antisecretory therapy including proton pump inhibitors is the main approach to the treatment of PUD, as well as the prevention of its complications. Integral to the treatment of patients with H. pylori-associated PU is the eradication therapy of the infection. It is reasonable to use a cytoprotector rebamipide, which accelerates ulcer healing and improves the resulting scar quality, as part of the pharmacotherapy of PUD. In addition, the use of rebamipide in H. pylori eradication therapy regimens contributes to increased efficiency of elimination of the microorganisms.
New treatment options for a patient with chronic heart failure and chronic obstructive pulmonary disease
Authors: Statsenko M. E. , Turkina S. V. , Lopushkova Yu. E. , Kosivtsova M. A. 
Published: April 2022

Introduction. The number of patients with chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) is increasing every year. In both CHF and COPD, secondary mitochondrial dysfunction is observed. In this regard, the attention of researchers is attracted by drugs that have their therapeutic effects at the level of mitochondria, one of which is meldonium. Meldonium has proven itself in the treatment of various diseases, however, the evaluation of the clinical efficacy of meldonium has not yet been carried out in comorbid patients with CHF and COPD.Aim. To study the effects of meldonium as part of basic therapy on the clinical condition, the main functional parameters of the heart and lungs, and the quality of life in patients with CHF and COPD.Materials and methods. The randomized open study included 60 patients with CHF II A stage, II–III FC (clinical recommendations of the RSC, OSSN 2020) and COPD I–III degree of airflow limitation (GOLD 2021 classification) in remission (age 45–70 years). The patients were divided into 2 groups: the 1st group – the main group (n = 30) with CHF and COPD took meldonium at a dosage of 1000 mg/day in addition to the basic therapy, the 2nd group – the control group (n = 30) was only on basic therapy for CHF and COPD. The observation period is 12 weeks.Results. In patients with CHF and COPD, in the dynamics of therapy with the inclusion of meldonium, as a result, the severity of clinical symptoms decreased, improvement was revealed in the main structural and functional parameters of the heart, external respiration function, and quality of life.Conclusions: a significant beneficial effect of combination therapy with the inclusion of meldonium on the clinical and functional parameters of the heart and lungs, indicators of quality of life in patients with CHF and COPD has been established, which makes it possible to recommend the use of meldonium as part of combination therapy in comorbid patients.