bluuebunny/crossref_metadata_2025_split huggingface dataset:
(Z, Z, Z)-3,6,9-nonadecadiene, a potential inhibitor of sex pheromone ofEctropis grisescensWarren (Lepidoptera: Geometridae): electroantennogram test, wind tunnel, and in silico study
Authors: Lu Hao , Yang Yun-Qiu , Yu Jie , Li Qian-Kun , Huang Yan-Zhang , Li Yuan-Chuan , Chen Qiao-Zhi , Wan Xiao-chun , Guo Feng 
Published: November 2022

AbstractApplication of sex pheromone is the most environmental-friendly technique to control pests. Moreover, it has been discovered that pheromone analogs can disturb or inhibit mating communication in some species of moths.Ectropis grisescensWarren (Lepidoptera: Geometridae), is the most severe tea defoliator in China. Thus, in our study, an analog of the pest sex pheromone component, (Z, Z, Z)-3,6,9-nonadecadiene (Z3Z6Z9-19:Hy), was selected to determine its potential activity in controlling the pest. Electroantennogram (EAG), Y-tube olfactometer, and wind tunnel experiments separately showed potential inhibition of Z3Z6Z9-19:Hy. The response elicited by Z3Z6Z9-19:Hy displayed a dose-dependent way in EAG test. Furthermore, in Y-tube olfactometer, percentage of positive response ofE. grisescensmales was significantly (P<0.01) reduced by Z3Z6Z9-19:Hy up to 70%. In wind tunnel, all types of behavioral response were significantly (P<0.01) inhibited by Z3Z6Z9-19:Hy, percentage of contacting source was utterly inhibited at the lowest dose tested. Based on these results, the combination of the analog and SNMP1 protein was also studied. Our study revealed the potential of Z3Z6Z9-19:Hy as a sex pheromone inhibitor, which would provide new perspectives in monitoring and mating disruption ofE. grisescensin pest-control strategies.
Environmental modulation of global epistasis is governed by effective genetic interactions
Authors: Diaz-Colunga Juan , Sanchez Alvaro , Ogbunugafor C. Brandon 
Published: November 2022

AbstractInteractions between mutations (epistasis) can add substantial complexity to genotype-phenotype maps, hampering our ability to predict evolution. Yet, recent studies have shown that the fitness effect of a mutation can often be predicted from the fitness of its genetic background using simple, linear relationships. This phenomenon, termedglobal epistasis, has been leveraged to reconstruct fitness landscapes and infer adaptive trajectories in a wide variety of contexts. However, little attention has been paid to how patterns of global epistasis may be affected by environmental variation — both from external sources or induced by the population itself through eco-evolutionary feedbacks — despite this variation frequently being a major driver of evolution. By analyzing a four-mutation fitness landscape, here we show that patterns of global epistasis can be strongly modulated by the concentration of a drug in the environment. Using previous theoretical results, we demonstrate that this modulation can be explained by how specific gene-by-gene interactions are modified by drug dose. Importantly, our results highlight the need to incorporate potential environmental variation into the global epistasis framework in order to predict adaptation in dynamic environments.
Bio-friendly long-term subcellular dynamic recording by self-supervised image enhancement microscopy
Authors: Zhang Guoxun , Li Xiaopeng , Zhang Yuanlong , Han Xiaofei , Li Xinyang , Yu Jinqiang , Liu Boqi , Wu Jiamin , Yu Li , Dai Qionghai 
Published: November 2022

AbstractFluorescence microscopy has become an indispensable tool for revealing the dynamic regulations of cells and organelles in high resolution noninvasively. However, stochastic noise inherently restricts the upper bonds of optical interrogation quality and exacerbates the observation fidelity in encountering joint demand of high frame rate, long-term, and low photobleaching and phototoxicity. Here, we propose DeepSeMi, a self-supervised-learning-based denoising framework capable of increasing SNR by over 12 dB across various conditions. With the introduction of newly designed eccentric blind-spot convolution filters, DeepSeMi accomplished efficacious denoising requiring no clean data as references and no compromise of spatiotemporal resolution on diverse imaging systems. The computationally 15-fold multiplied photon budget in a standard confocal microscope by DeepSeMi allows for recording organelle interactions in four colors and high-frame-rate across tens of thousands of frames, monitoring migrasomes and retractosomes over a half day, and imaging ultra-phototoxicity-sensitiveDictyosteliumcells over thousands of frames, all faithfully and sample-friendly. Through comprehensive validations across various cells and species over various instruments, we prove DeepSeMi is a versatile tool for reliably and bio-friendly breaking the shot-noise limit, facilitating automated analysis of massive data about cell migrations and organelle interactions.
Learning low-dimensional generalizable natural features from retina using a U-net
Authors: Wang Siwei , Hoshal Benjamin , de Laittre Elizabeth A , Marre Olivier , Berry Michael J , Palmer Stephanie E 
Published: November 2022

AbstractMuch of sensory neuroscience focuses on presenting stimuli that are chosen by the experimenter because they are parametric and easy to sample and are thought to be behaviorally relevant to the organism. However, it is not generally known what these relevant features are in complex, natural scenes. This work focuses on using the retinal encoding of natural movies to determine the presumably behaviorally-relevant features that the brain represents. It is prohibitive to parameterize a natural movie and its respective retinal encoding fully. We use time within a natural movie as a proxy for the whole suite of features evolving across the scene. We then use a task-agnostic deep architecture, an encoder-decoder, to model the retinal encoding process and characterize its representation of “time in the natural scene” in a compressed latent space. In our end-to-end training, an encoder learns a compressed latent representation from a large population of salamander retinal ganglion cells responding to natural movies, while a decoder samples from this compressed latent space to generate the appropriate future movie frame. By comparing latent representations of retinal activity from three movies, we find that the retina has a generalizable encoding for time in the natural scene: the precise, low-dimensional representation of time learned from one movie can be used to represent time in a different movie, with up to 17 ms resolution. We then show that static textures and velocity features of a natural movie are synergistic. The retina simultaneously encodes both to establishes a generalizable, low-dimensional representation of time in the natural scene.
Metabolic clearance rate modeling: A translational approach to quantifying cerebral metabolism using hyperpolarized [1-13C]pyruvate
Authors: Grist James T. , Bøgh Nikolaj , Hansen Esben Søvsø , Schneider Anna M. , Healicon Richard , Ball Vicky , Miller Jack J.J.J. , Smart Sean , Couch Yvonne , Buchan Alastair , Tyler Damian J. , Laustsen Christoffer 
Published: November 2022

AbstractHyperpolarized carbon-13 MRI is a promising technique forin vivometabolic interrogation of alterations between health and disease. This study introduces a model-free formalism for quantifying the metabolic information in hyperpolarized imaging.This study investigated a novel model-free perfusion and metabolic clearance rate (MCR) model in pre-clinical stroke and in the healthy human brain.Simulations showed that the proposed model was robust to perturbations in T1, transmit B1, and kPL. A significant difference in ipsilateral vs contralateral pyruvate derived cerebral blood flow (CBF) was detected in rats (140 ± 2 vs 89 ± 6 mL/100g/min, p < 0.01, respectively) and pigs (139 ± 12 vs 95 ± 5 mL/100g/min, p = 0.04, respectively), along with an increase in fractional metabolism (26 ± 5 vs 4 ± 2 %, p < 0.01, respectively) in the rodent brain. In addition, a significant increase in ipsilateral vs contralateral MCR (0.034 ± 0.007 vs 0.017 ± 0.02 s-1, p = 0.03, respectively) and a decrease in mean transit time (MTT) (31 ± 8 vs 60 ± 2, p = 0.04, respectively) was observed in the porcine brain. In conclusion, MCR mapping is a simple and robust approach to the post-processing of hyperpolarized magnetic resonance imaging.
Decipher macrophage-fibroblast-cardiomyocyte signaling interactions associated with heart failure using deep graph neural network models and single-cell RNA-seq data
Authors: Li Wenyu , Feng Jiarui , Payne Philip , Chen Yixin , Li Fuhai 
Published: November 2022

AbstractHeart failure is a major cause of mortality. In these recent studies, novel evidence, using single-cell transcriptomic data, was reported to indicate that macrophages and fibroblasts play important roles in heart failure. The involvement of macrophages in inflammation and the relationship between inflammation and fibrosis has been established. However, the underlying molecular targets and signaling pathways mediating signaling interactions among macrophages, fibroblasts, and cardiomyocytes remain unclear. In this study, analyzing the scRNA-seq datasets using deep learning models, we ranked the cell-type specific molecular targets; and uncovered the dysfunctional intra- and inter-cellular signaling pathways that are potentially associated with heart failure. The signaling targets and pathways could be helpful in identifying effective medications for heart disease inflammation management to prevent heart failure.
A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis
Authors: Zhang Bohua , Wu Huaiyu , Kim Howuk , Welch Phoebe J. , Cornett Ashley , Stocker Greyson , Nogueira Raul G. , Kim Jinwook , Owens Gabe , Dayton Paul , Xu Zhen , Shi Chengzhi , Jiang Xiaoning 
Published: November 2022

AbstractThis research aims to demonstrate a novel vortex ultrasound enabled endovascular thrombolysis method designed for treating cerebral venous sinus thrombosis (CVST). This is a topic of significant importance since current treatment modalities for CVST still fail in as many as 20-40% of the cases and the incidence of CVST has increased since the outbreak of the COVID-19 pandemic. Compared with conventional anticoagulant or thrombolytic drugs, sonothrombolysis has the potential to remarkably shorten the required treatment time owing to the direct clot targeting with acoustic waves. However, previously reported strategies for sonothrombolysis have not demonstrated clinically meaningful outcomes (e.g., recanalization within 30 minutes) in treating large, completely occluded veins or arteries. In this paper, we demonstrated a new vortex ultrasound technique for endovascular sonothrombolysis utilizing wave-matter interaction-induced shear stress to enhance the lytic rate substantially. Ourin vitroexperiment showed that the lytic rate was increased by at least 64.3 % compared with the nonvortex endovascular ultrasound treatment. A 3.1 g, 7.5 cm long, completely occludedin vitro3D model of acute CVST was fully recanalized within 8 minutes with a record-high lytic rate of 237.5 mg/min for acute bovine clotin vitro. Furthermore, we confirmed that the vortex ultrasound causes no vessel wall damage overex vivobovine veins. This vortex ultrasound thrombolysis technique potentially presents a new life-saving tool for severe CVST cases that cannot be efficaciously treated using existing therapies.
POGZ suppresses 2C transcriptional program and retrotransposable elements
Authors: Sun XY , Zhang TZ , Cheng LX , Jiang W , Sun YH 
Published: November 2022

ABSTRACTThePOGZgene has been found frequently mutated in neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) and intellectual disability (ID). We have recently shown that POGZ maintains mouse embryonic stem cells (ESCs) as a chromatin regulator and a transcription factor. However, the exact mechanisms remain unclear. Here we show that POGZ plays important role in the maintenance of ESCs by silencing theDuxgene and certain endogenous retroviruses (ERVs). POGZ directly binds to theDuxgene and ERVs, and its depletion leads to up-regulation of 2C genes and the repetitive elements such as RLTR9E and IAP (the intracisternal A-type particles), resulting in transition to a 2C-like (2CLC) state and genome instability. POGZ regulates ESC heterochromatin state by association and recruiting TRIM28 and SETDB1, and its loss leads to increased H3K4me3 and H3K27ac, and decreased H3K9me3 at local chromatin. Activation of POGZ-bound ERVs is associated with up-regulation of nearby neural genes. Chimeric transcripts that are initiated within ERVs and spliced to genic exons are highly expressed inPogz−/−ESCs. Our findings establish that POGZ is required for the maintenance of ESCs by repressingDuxand silencing ERVs, which may provide important insights into the disease pathology caused by POGZ dysfunction.HighlightsPOGZ depletion leads to activation of 2C genesPOGZ depletion leads to deregulation of ERVsPOGZ directly binds and repressesDuxPOGZ associates with TRIM28/SETDB1 to maintain heterochromatin state to silence ERVsActivation of POGZ-bound ERVs is associated with up-regulation of nearby neural genes
Seeing our hand or a tool during visually-guided actions: different effects on the somatosensory and visual cortices
Authors: Mathieu Benjamin , Abillama Antonin , Moré Simon , Mercier Catherine , Simoneau Martin , Danna Jérémy , Mouchnino Laurence , Blouin Jean 
Published: November 2022

AbstractThe processing of proprioceptive information in the context of a conflict between visual and somatosensory feedbacks deteriorates motor performance. Previous studies have shown that seeing one’s hand increases the weighting assigned to arm somatosensory inputs. In this light, we hypothesized that the sensory conflict, when tracing the contour of a shape with mirror-reversed vision, will be greater for participants who trace with a stylus seen in their hand (Hand group, n=17) than for participants who trace with the tip of rod without seen their hand (Tool group, n=15). Based on this hypothesis, we predicted that the tracing performance with mirror vision will be more deteriorated for the Hand group than for the Tool group, and we predicted a greater gating of somatosensory information for the Hand group to reduce the sensory conflict. The participants of both groups followed the outline of a shape in two visual conditions. Direct vision: the participants saw the hand or portion of a light 40 cm rod directly. Mirror Vision: the hand or the rod was seen through a mirror. We measured tracing performance using a digitizing tablet and the cortical activity with electroencephalography. Behavioral analyses revealed that the tracing performance of both groups was similarly impaired by mirror vision. However, contrasting the spectral content of the cortical oscillatory activity between the Mirror and Direct conditions, we observed that tracing with mirror vision resulted in significantly larger alpha (8-12 Hz) and beta (15-25 Hz) powers in the somatosensory cortex for participants of the Hand group. The somatosensory alpha and beta powers did not significantly differ between Mirror and Direct vision conditions for the Tool group. For both groups, tracing with mirror vision altered the activity of the visual cortex: decreased alpha power for the Hand group, decreased alpha and beta power for the Tool group. Overall, these results suggest that seeing the hand enhanced the sensory conflict when tracing with mirror vision and that the increase of alpha and beta powers in the somatosensory cortex served to reduce the weight assigned to somatosensory information. The increased activity of the visual cortex observed for both groups in the mirror vision condition suggests greater visual processing with increased task difficulty. Finally, the fact that the participants of the Tool group did not show better tracing performance than those of the Hand group suggests that tracing deterioration resulted from a sensorimotor conflict (as opposed to a visuo-proprioceptive conflict).
Hospitality enterprises’ revival through crowdfunding: a cross-country study
Authors: Baber Hasnan , Ramkissoon Haywantee , Salem Islam Elbayoumi , Ghasemi Vahid , Munim Ziaul Haque 
Published: November 2022

Purpose
The purpose of this study is to suggest a reward-based crowdfunding approach and test customers’ financial contribution behaviour (FCB) as a fundraising strategy for hospitality enterprises.

Design/methodology/approach
To investigate this initiative, a conceptual model motivated by the theory of planned behaviour, integrating economic, emotional, social and altruistic values, perceived risk and electronic word of mouth has been considered. Partial least square structural equation modelling is applied to test the model. Data was collected from 263 respondents across three regions – Europe, Asia and Middle East and North Africa (MENA).

Findings
Findings revealed that attitude, self-efficacy and subjective norm of the customers positively influence their financial contribution intention. Further, Asian customers demonstrate significantly higher FCB in comparison to MENA.

Research limitations/implications
This study will be helpful for the hospitality players to raise the funds during the crisis and survive to pay the reward back to the customers. This study will be helpful to the crowdfunding platforms to understand the factors which influence the contribution behaviour.

Practical implications
The results of this study can encourage hoteliers and other hospitality players looking to approach their funding needs through crowdfunding by providing them a guide to maximise their possibility and level of success.

Originality/value
Hospitality businesses demand new approaches and strategies to keep operating during COVID-19 and post-COVID-19 time. This research is original to provide insights into customer contribution intentions during COVID-19.
Between quandary and squander: an analysis of preservation practices of vernacular literature at university libraries
Authors: Pandya Chintan , Gohil Jasmine 
Published: November 2022

PurposeVernacular materials present stories of different cultures and people. Management of these resources is not just about storing records for history and research; they also represent the democratic credentials of the government. Libraries play a crucial role here. The purpose of this study is to look into the existing preservation practices at university libraries, such as digitisation.Design/methodology/approachThis study has applied descriptive research methods for the systematic literature analysis along with structured questionnaires for the primary data collection. The research sample was 50 university libraries spread in different provinces in India.FindingsThe analysis critically describes the strategies of implementing the preservation practices and factors of deterioration of the old and rare materials. The findings of the study revealed that the majority of the university libraries are using digitisation of rare materials, and binding, de-acidification and pest control were common practices of restoration.Originality/valueTo the best of the authors’ knowledge, based on the literature analysis, the primary investigation and research gap indicated that no attempts have been made to explore the digitisation practice and other restoration approaches among university libraries. Preservation practices vary from case to case; however, such common practices at these university libraries provide evidence-based examples which is useful for the larger group of people to choose more suitable conservation techniques. This study will help researchers of conservationists to identify the factors of preservation and conservation practices at university libraries in India in special respect to the rare vernacular literature.
Permanent layoff and consumer credit card loss forecasting
Authors: Liu Zilong , Liang Hongyan 
Published: November 2022

PurposeThe unemployment rate (UR) is the leading macroeconomic indicator used in the credit card loss forecasting. COVID-19 pandemic has caused an unprecedented level of volatility in the labor market variables, leading to new challenges to use UR in the credit risk modeling framework. This paper examines the dynamic relationship between the credit card charge-off rate and the unemployment rate over time.Design/methodology/approachThis study uses quarterly observations of charge-off rates on credit card loans of all commercial banks from Q1 1990 to Q4 2020. Univariate, multivariable, machine learning, and regime-switching time series modeling are employed in this research.FindingsThe authors decompose UR into two components – temporary and permanent UR. The authors find the spike in UR during COVID-19 is mainly attributed to the surge in temporary layoffs. More importantly, the authors find that the credit card charge-off rate is primarily driven by permanent UR while temporary UR has little predictive power. During recessions, permanent UR seems to be a stronger indicator than total UR. This research highlights the importance of using permanent UR for credit risk modeling.Originality/valueThe findings in the research can be applied to the credit card loss forecasting and CECL reserve models. In addition, this research also has implications for banks, macroeconomic data vendors, regulators, and policymakers.
Cognitive job crafting: an intervening mechanism between intrinsic motivation and affective well-being
Authors: Kilic Eren , Kitapci Hakan 
Published: November 2022

Purpose
Employees often reframe their work roles and ascribe meaning to their jobs, which is called cognitive job crafting (CJC). Although scholars have identified the importance of CJC, there remains a lack of evidence on what motivational characteristics affect initiating such cognitive changes and how these cognitive changes affect one’s well-being. Drawing on job design and self-determination theories, this study aims to investigate how intrinsic motivations affect CJC and, thus, optimize affective well-being (AWB) through cognitive changes.

Design/methodology/approach
The cross-sectional data were collected using online questionnaires from 327 white-collar employees working in various organizations. The validity of the hypothesized model was tested by using structural equation modeling. Hypotheses were tested using Process analysis.

Findings
The findings showed that intrinsic motivations (i.e. self-determination and meaning) were positively related to CJC, which resulted in increased positive affection and decreased negative affection, reflecting a mediating mechanism.

Practical implications
The authors suggest that practitioners can enhance employee well-being by implementing policies that value proactive job redesign strategies (e.g. job crafting training). Thus, the practitioners may motivate employees to craft their jobs, which leads employees to engage and perform well.

Originality/value
The results of this study contribute to a deeper understanding of job crafting initiatives by providing evidence for the role of motivational and cognitive mechanisms that help optimize well-being at work.