bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gravity-Assist as a Possible Solution to Save Earth from Global Warming
Authors: Rahvar Sohrab 
Published: August 2022

Abstract
Global warming is one of the problems of human civilization and decarbonization policy is the main solution to this problem. In this work, we propose an alternative method of using the gravity-assist by the asteroids to increase the orbital distance of the Earth from the Sun. While this proposal is far from the present day technical potential however, we show that in principle this is a doable project.Let us assume manipulating the orbit of asteroids in the asteroid belt by solar sailing and propulsion engines to guide them towards the Mars orbit. A gravitational scattering from Mars can put asteroids in a favorable direction to provide an energy loss scattering from the Earth. The result would be increasing the orbital distance of the earth and consequently cooling down the Earth's temperature. We calculate the increase in the orbital distance of the earth for each scattering.
Loss of Interleukin–18 Negative–Feedback Associated with Severity and Mortality in Prospective Cohort Study of 206 Hospitalised COVID–19 Patients
Authors: Nasser Syed Muhammad Tahir , Rana Anas A , Doffinger Rainer , Kafizas Andreas , Khan Tauseef A , Nasser Shuaib 
Published: August 2022

Abstract
Background: Divergence between deterioration to life–threatening COVID–19 or clinical improvement occurs for most within the first 14 days of symptoms. Life–threatening COVID–19 shares clinical similarities with Macrophage Activation Syndrome, which can be driven by elevated Free Interleukin–18 (IL–18) due to failure of negative-feedback release of IL–18 binding protein (IL–18bp). We therefore designed a prospective, longitudinal cohort study to examine IL–18 negative–feedback control in relation to COVID–19 severity and mortality from symptom day 15 onwards. Methods: 662 blood samples, matched to time from symptom onset, from 206 COVID–19 patients were analysed by enzyme–linked immunosorbent assay for IL–18 and IL–18bp, enabling calculation of free IL–18 (fIL–18) using the updated dissociation constant (Kd) of 0.05 nanomoles. Adjusted multivariate regression analysis was used to assess the relationship between highest fIL–18 and outcome measures of COVID-19 severity and mortality. Results: Up to symptom day 14, mean fIL–18 levels increase in all patients. Levels in survivors declined thereafter, but remained elevated in non–survivors, due to IL–18 production without commensurate IL–18bp release. Adjusted regression analysis from symptom day 15 onwards showed a 100 mmHg decrease in Pa02/Fi02 (primary outcome) for each 37.7 pg/ml increase in highest fIL–18 (p < 0.03). Per 50 pg/ml increase in highest fIL–18, adjusted logistic regression gave an odds–ratio (OR) for crude 60–day mortality of 1.41 (1.1 – 2.0) (p < 0.03), and an OR for death with hypoxaemic respiratory failure of 1.90 [1.3 – 3.1] (p < 0.01). Highest fIL–18 was associated also with organ failure, with an increase of 63.67 pg/ml for every additional organ supported (p < 0.01) in patients with hypoxaemic respiratory failure. In this same sub-group, highest fIL–18 showed a direct correlation with Neutrophil/Lymphocyte ratio, with an increase in fIL–18 by 3.54 pg/ml (p < 0.03) for each unit increase. Conclusions: Loss of IL–18 negative–feedback control, from symptom day 15 onwards is associated with COVID–19 severity and mortality. ISRCTN: #13450549; registration date: 30/12/2020.
Causal impact of fire on expansion of a globally rare wetland plant: a 40-year Bayesian time series analysis
Authors: Landau Deborah , Cahalan Gabriel D. , Batley Prathiba Natesan 
Published: August 2022

Abstract
Background Canby’s dropwort ( Oxypolis canbyi (J.M. Coult. & Rose) Fernald) was listed as federally endangered in 1986, yet the species has continued to decline and is no longer found in 11 counties throughout its former range. The seasonal wetlands in which this forb occur are disappearing from the landscape, often closing in and transitioning to wet forest, drained, or converted to agriculture. We document the effects of reintroducing fire to the only population of O. canbyi in Maryland, and examine the resulting population increase using Bayesian interrupted time series analysis with a counterfactual. Results The slopes for the phases 1 (no intervention), 2 (cutting), and 3 (fire) were 2.57 [95%CI -1.05, 4.07], -2.96 [95%CI -6.29, 0.4], and 15.71 [95%CI 10.06, 21.33], respectively. After cutting woody vegetation, 3.74 times more stems of dropwort per year were produced over the baseline without intervention. Once fire was reintroduced, 10.80 times more dropwort stems per year were produced in comparison to the time period after cutting woody vegetation. The counterfactual prediction showed that in the absence of the fire intervention, dropwort stem production would likely have declined. Conclusions Cutting woody vegetation set the stage for fine fuels by increasing sun exposure on wetland grasses. It was only after fire was reintroduced that the population of plants expanded significantly in extent and flower production. A process for model selection with a directed acyclic graph followed by Bayesian interrupted time series analysis and a counterfactual was useful for causal inference. Application of fire is an important step in recovery of the federally endangered dropwort.
Prognostic factors for the long term outcome after surgical celiac artery decompression in MALS
Authors: Woestemeier Anna , Semaan Alexander , Block Andreas , Arensmeyer Jan , Dohmen Jonas , Kania Alexander , Verrel Frauke , Mücke Martin , Kalff Jörg C. , Lingohr Philipp 
Published: August 2022

Abstract
Background The median arcuate ligament syndrome (MALS) is a rare disease caused by compression of the celiac artery (ORPHA: 293208). Surgical treatment of MALS aims to restore normal celiac blood flow by laparoscopic celiac artery decompression. However, surgical success rates vary widely between patients, therefore adequate selection of patients is essential to improve surgical outcome. Symptoms of MALS might also overlap with other chronic multi-system disorders such as mast cell activation syndrome (MCAS). So far, no clinical or radiological parameter was found to be predictive of the postoperative outcome. We therefore aimed to study preclinical parameters in one of the largest MALS cohorts with the aim to identify patients that would benefit from surgical MAL release. Results Analyzing 20 MALS patients that underwent surgical celiac artery decompression, we found 60% of patients (12/20) had a postoperative relief of their symptoms and a simultaneous decrease of analgetic use. No demographic, radiologic or operative parameter was able to predict postoperative symptom relief. However, mast cell activation syndrome correlated significantly (p=0.04) with persistent symptoms after the operation. Conclusions Overall, laparoscopic MAL release is the only effective treatment for MALS and can provide immediate symptomatic relief. Despite the missing predictive value of demographic and imaging data, our data show a correlation between persistent symptoms and a co-existing mast cell activation syndrome. This suggests that MACS symptoms might be interpreted as MALS symptoms in the presence of celiac artery stenosis and therefore surgical treatment should be evaluated carefully. Overall, selection of patients who are most likely to respond to surgical MAL release may best be accomplished by an interdisciplinary team of gastroenterologists, radiologists and surgeons.
Dynamical analysis of astrocyte-induced neuronal hyper-excitation
Authors: Ji Quanbao , Qie Xinxin , Ye Min 
Published: August 2022

Abstract
This paper introduces a computational model of integrated information in bidirectional neuron-astrocyte communication. Dynamical analysis and information transfer process are studied when stimulation of metabotropic glutamate is loaded into neuron and astrocyte in coupled model, respectively. The results show that the loading glutamate stimulus and coupling strength cause neuronal hyper-excitation, which is in some way linked to the epileptic instabilities. A period of sustained neuronal firing activities could continue after cessation of stimulation because of how long it takes for calcium concentration in astrocyte to decrease to the steady-state. Additionally, we also found that reducing the feedback of astrocyte could effectively inhibit neuronal seizure-like firing from the aspect of neuronal energy consumption in somatic firing.
Potential of Plantation Trees for Biomass and Carbon Sequestration in Foothills of Jakanari Forest, Coimbatore, Western Tamil Nadu, India
Authors: Natarajan Hari Prasath , Arunachalam Balasubramanian , Muthuswamy Sivaprakash , Suthandhirajan Radhakrishnan , Ganesan Swathiga , Satheedan Anjali , Vellan Manimaran 
Published: August 2022

AbstractAfforestation and reforestation have a greater potential for appropriate absorbtion of carbon from environment that helps in mitigating and reducing the global warming nature of both the developing and developed countries. Hence, the present study for assessing the carbon sequestration potential of 7 trees (Dalbergia latifolia,Albizia lebbeck,Dalbergia sissoo,Gmelina arborea,Swietenia macrophylla,Tectona grandis, andTerminalia bellirica) have been evaluated in Forest College and Research Institute (FC&RI), Mettupalayam in the surroundings of the Jakanari Reserve Forest, Northern part of Coimbatore for its biomass of trees, biomass carbon, ecophysiological (Photosynthesis and Transpiration rate) attributes and carbon isotope discrimination potential of trees. The study revealed thatDalbergia sissooandTectona grandishave the highest potential for biomass and biomass carbon production and as well as these two species also performed well under the eco-physiological condition by having the highest potential of growing in water scarcity conditions through carbon isotope discrimination identification.Dalbergia latifoliaandSwietenia macrophyllaare not able to cope with the prevailing dry condition; hence these species can be used for moist land conditions. Confirmation of the present study reveals that theDalbergia sissooandTectona grandisare the best suitable tree species recommended for maximum carbon sequestration potential.
pH of water intercalated into graphite oxide as determined by EPR spectroscopy
Authors: Yankova Tatiana S. , Chumakova Natalia A. 
Published: August 2022

AbstractTwo pH-sensitive spin probes 4-(methylamino)-2-ethyl-5,5-dimethyl-4-pyridine-2-yl-2,5-dihydro-1H-imidazol-1-oxyl (DPI, also known as MEP) and 2,2,3,5,5-pentamethyl-2,5-dihydro-1H-imidazol-1-oxyl (MTI) were used to measure pH of water intercalated in Brodie graphite oxide. pH value was found to be 2.25 ± 0.05 immediately after adding of water to graphite oxide and decreased to 1.75 ± 0.05 duringca.30 hours.
Using the Framework for Reporting Adaptations and Modifications-Expanded (FRAME) to study lung cancer screening adaptations in the Veterans Health Administration
Authors: Strayer Thomas E. , Spalluto Lucy B. , Burns Abby , Lindsell Christopher J. , Henschke Claudia I. , Yankelevitz David F. , Moghanaki Drew , Dittus Robert S. , Vogus Timothy J. , Audet Carolyn , Kripalani Sunil , Roumie Christianne L. , Lewis Jennifer A. 
Published: August 2022

Abstract
Background: Lung cancer screening includes identification of eligible individuals, shared decision-making inclusive of tobacco cessation, and management of screening results. Adaptations to the implemented processes for lung cancer screening in situ are understudied and underreported, with potential loss of important considerations for improved implementation. The Framework for Reporting Adaptations and Modifications-Expanded (FRAME) allows for systematic enumeration of adaptations to implementations of evidence-based practices. We used FRAME to study adaptations in lung cancer screening processes that were implemented as part of a Veterans Health Administration (VHA) Enterprise-Wide Initiative.Methods: We conducted semi-structured interviews at baseline and 1-year intervals with lung cancer screening program navigators at 10 Veterans Affairs Medical Centers (VAMC) between 2019-2021. Using this data, we developed baseline (1st) process maps for each program. In subsequent years (year 1 and year 2), each program navigator reviewed the process maps. Adaptations in screening processes were identified, recorded and mapped to FRAME categories. Results: A total of 14 program navigators across 10 VHA lung cancer screening programs participated in 20 interviews. In year 1 (2019-2020), seven programs were operational and of these, three reported adaptations to their screening process that were either planned and in response to COVID-19. In year 2 (2020-2021), all 10 programs were operational. Programs reported 14 adaptations in year 2. These adaptations were both planned and unplanned and often triggered by increased workload; 57% of year 2 adaptations were related to identification and eligibility of Veterans and 43% were related to follow-up with Veterans for screening results. Throughout the 2 years, adaptations related to data management and patient tracking occurred in 6 of 10 programs to improve the data collection and tracking of Veterans in the screening process. Conclusions: Using FRAME, we found that adaptations occurred throughout the lung cancer screening process but primarily in the areas of patient identification and communication of results. These findings highlight considerations for lung cancer screening implementation and potential areas for future intervention.
Priming genetic explanations for addiction weakens the relationship between biological essentialism and stigma
Authors: Siddiqui Hasan , Rutherford M.D. 
Published: August 2022

AbstractDrug addiction is stigmatized, and this stigma contributes to poor outcomes for individuals with addiction. Researchers have argued that providing genetic explanations of addiction will reduce stigma (Richter et al., 2019), but there has been limited research testing this. We presented participants with news articles that either provided genetic or anti-genetic explanations of addiction. Participants’ biological essentialism correlated with stigma in the context of both opioid and methamphetamine addiction. However, this relationship was attenuated when participants were presented with news articles that provided a genetic explanation for addiction. This suggests that the relationship between essentialism and stigma is malleable.
Dynamics of degenerate and nondegenerate solitons in the two-component nonlinear Schrodinger equations coupled to Boussinesq equation
Authors: Chen Xiang , Mihalache Dumitru , rao jiguang 
Published: August 2022

Abstract
The paper studies the dynamics of degenerate and nondegenerate bright solitons and their collisions in the two-component nonlinear Schr\"odinger equations coupled to Boussinesq equation. The degenerate solitons that have only single-hump profiles, exhibit both elastic and inelastic collisions, and their velocities are identical in the two short wave (SW) components and in the long wave (LW) component. The nondegenerate single solitons have two different forms: one of them has double- or single-hump profiles and identical velocities in all SW and LW components, and the other one only admits single-hump profiles and has unequal velocities in the two SW components. The collisions of nondegenerate solitons cannot result in the redistribution of soliton intensities. Three different types of collisions of nondegenerate two-soliton solutions are studied in detail.
Preparation, characteristics and cytotoxicity of green synthesized selenium nanoparticles using Paenibacillus motobuensis LY5201 isolated from the local specialty food of longevity area
Authors: Long Qian , He Sheng-bin , Sun Jian , Chen Quan-zhi , Bao Hao-dong , Liang Teng-yue , Liang Bao-yue , Cui Lan-yu 
Published: August 2022

Abstract
Selenium is an essential micronutrient element. For the extremely biotoxic of selenite, Selenium nanoparticles (SeNPs) is gaining increasing interest. In this work, a selenium-enriched strain with highly selenite-resistant (up to 173 mmol/L) was isolated from the local specialty food of longevity area and identified as Paenibacillus motobuensis (P. motobuensis) LY5201. Most of the SeNPs is accumulated extracellular. SeNPs were around spherical with a diameter of approximately 100 nm. The X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy showed that the purified SeNPs consisted of selenium and proteins. Our results suggested that P. motobuensis LY5201could be a suitable and robust biocatalyst for SeNPs synthesis. In addition, the cytotoxicity effect and the anti-invasive activity of SeNPs on the HepG2 showed an inhibitory effect on HepG2, indicating that SeNPs could be used as a potential anticancer drug.
Evaluation and composition analysis of coal abandonment in abandoned mines
Authors: Liu Jinzhao , Chen Xiangjun , Feng Shuailong , Li Xinjian 
Published: August 2022

Abstract
The development and utilisation of gas resources in closed mines is based on statistics of coal reserves that have been abandoned for a variety of reasons, with the evaluation method and procedure playing a crucial role as the core technology. The following conclusions are reached through the analysis of the mass conservation method and scenario reproduction method, taking the differential supply of abandoned mine residual coal resources to gas resources as the research goal, taking into account the different levels of richness of geological, production, and recovery data: (1) The four provinces of "Shanxi, Shaanxi, Henan, and Guizhou" formed the first tier of an industry pattern. (2) The scenario simulation technique is appropriate for mines with incomplete data or long-closed pits, whereas the mass conservation method is appropriate for abandoned mines with complete means of production. (3) Due to the steady decline in the proportion of coal pillar resources in residual coal resources and the gradual increase in the proportion of loose coal resources, there is a differentiated supply of abandoned mine gas resources as a result of the technical reform of coal mining methods.
A novel HPLC method for selexipag in human plasma and application to a pharmacokinetic study
Authors: Ceylan Burhan , Tırıs Gizem , Tekkeli S. Evrim Kepekci , Önal Cem , Önal Armağan 
Published: August 2022

Abstract
A novel simple and cost effective HPLC technique was presented for the quantification of selexipag (SLP) in human plasma sample and the technique's applicability to a pharmacokinetic investigation. C18 (5 µm x 4.6 mm x 150 mm) column was used at 30°C with a mobile phase consisted of acetonitrile: % 0.5 formic acid (65:35 v/v) at 1.2 mL min− 1 flow rate. The linearity range is 10–125 ng mL− 1. As sample preparation step human plasma was precipitated with acetonitrile and the detection was provided at 300 nm. LOD is found to be 3.3 ng mL− 1 for drug. Validation of the studied methods was carried out according to EMA guideline. The new method applied on a pharmacokinetic study by administration of 800 mg SLP to a healthy volunteer and parameters like AUC0 − 24, AUC0−∞, Cmax, tmax, and t1/2 were assessed.
Non-fragile robust output feedback control of uncertain active
suspension systems with stochastic network-induced delay
Authors: Zhao Jing , Zhu Ya juan , Wong Pak Kin , Li Wen feng , Yang Zhi xin , Li Pan shuo , Song Chong hui 
Published: August 2022

Abstract
The vehicle active suspension has attracted considerable attention owing to its great contributions to the vertical dynamics of vehicle. This paper investigates the robust non-fragile H ∞ output feedback control problem of the uncertain vehicle active suspension with stochastic network-induced delay. Firstly, taking the variation of sprung and unsprung masses into consideration, an interval type-2 (IT-2) Takagi-Sugeno (TS) fuzzy model is introduced to describe the nonlinear characteristics of active suspension systems (ASSs). Secondly, to ensure that the control strategy is practicable when some states are unmeasured, a novel output feedback method is proposed by employing a variable substitution approach. Meanwhile, in order to approximate the real physical conditions of the control system, the gain perturbations are taken into account. Thirdly, with regard to the complexity of signal transmission delay in network control process, a more generalized lumped delay form is employed to represent the network-induced delay. Moreover, to describe the stochasticity of lumped delay, a Markovian process is introduced. Finally, both numerical simulations and experimental tests are carried out to examine the effectiveness and practicability of the proposed controller.
Impact of slow infusion of sodium bicarbonate solution on hemodynamic resuscitation of patients following blood loss during surgery: A randomized controlled trial
Authors: Khajavi Mohammad Reza , Aghaie Maryam , Malek Mohsen kupaei , Aghaie Marjan , Bidkhori Mohammad , Behseresht Alireza 
Published: August 2022

Abstract
Background: Maintaining systemic blood pressure and tissue perfusion in patients during hemorrhagic shock due to surgery is critical. In this study, the hemodynamic effects of bicarbonate infusion after hemorrhagic hypotension during surgery was investigated.Methods: This prospective clinical trial study was conducted on 59 candidates for total hip surgery at Sina hospital in 2020-2021. During surgery patients who had blood loss above 400 milliliters within 15 minutes and have systolic blood pressure (SBP) less than 90 mm Hg, randomly divided to bicarbonate(B) and control(C) groups. If bleeding reaches the maximum tolerable limit, in each group transfusion is started. At the end of operation an arterial blood sample is sent to measure blood gases and lactate level. Hemodynamic parameters, blood gas analysis and lactic acid changes before and after intervention was analyzed in each group. Results: A total number of 59 patients were analyzed. The SBP and mean arterial blood pressure in the B group increased after 10 minutes and remained higher than C group until 50 minutes of study. Also, the acid-base values in the B group maintained in the normal range in comparison with C group. Finally, the blood lactate level in B group was lower than the C group.Conclusions: In patients with hemorrhagic hypotension during surgery, the use of slow rate 7.5% sodium bicarbonate solution infusion along with other crystalloids can correct the patient's hypotension and metabolic acidosis compared to crystalloids alone.