bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymerisation‐Induced Self‐Assembly of Graft Copolymers
Authors: Häkkinen Satu , Tanaka Joji , Garcia Maset Ramón , Hall Stephen C. L. , Huband Steven , Rho Julia Y. , Song Qiao , Perrier Sébastien 
Published: August 2022

AbstractWe report the polymerisation‐induced self‐assembly of poly(lauryl methacrylate)‐graft‐poly(benzyl methacrylate) copolymers during reversible addition‐fragmentation chain transfer (RAFT) grafting from polymerisation in a backbone‐selective solvent. Electron microscopy images suggest the phase separation of grafts to result in a network of spherical particles, due to the ability of the branched architecture to freeze chain entanglements and to bridge core domains. Small‐angle X‐ray scattering data suggest the architecture promotes the formation of multicore micelles, the core morphology of which transitions from spheres to worms, vesicles, and inverted micelles with increasing volume fraction of the grafts. A time‐resolved SAXS study is presented to illustrate the formation of the inverted phase during a polymerisation. The grafted architecture gives access to unusual morphologies and provides exciting new handles for controlling the polymer structure and material properties.
A Regio‐ and Diastereoselective Stille Coupling/Intramolecular Diels–Alder Cascade for the Generation of Fused Pyridines and Application in the Synthesis of (+)‐Lycopladine A and (−)‐Lycoposerramine R
Authors: Sim Kyu‐Hyun , ul Ansari Thameem , Park Yong‐Gyu , Jeong Yeolib , Oh Sang‐Ha , Min Hye‐Won , Jeon Da‐Yoon , Kim Hyunwoo , Cho Cheon‐Gyu 
Published: August 2022

Abstract2‐Pyrones with a chiral branched allylic silyl ether substituent underwent intramolecular Diels–Alder reactions with remarkably high π‐facial‐ and endo‐selectivities. The resulting diastereomerically and enantiomerically pure cycloadducts were transformed into the natural products (+)‐lycopladine A and (−)‐lycoposerramine R.
Structure–Uptake Relationship Study of DABCYL Derivatives Linked to Cyclic Cell‐Penetrating Peptides for Live‐Cell Delivery of Synthetic Proteins
Authors: Saha Abhishek , Mandal Shaswati , Arafiles Jan Vincent V. , Gómez‐González Jacobo , Hackenberger Christian P. R. , Brik Ashraf 
Published: August 2022

AbstractModifying cyclic cell‐penetrating deca‐arginine (cR10) peptides with 4‐(4‐dimethylaminophenylazo)benzoic acid (DABCYL) improves the uptake efficiency of synthetic ubiquitin (Ub) cargoes into living cells. To probe the role of the DABCYL moiety, we performed time‐lapse microscopy and fluorescence lifetime imaging microscopy (FLIM) of fluorescent DABCYL‐R10 to evaluate the impact on cell entry by the formation of nucleation zones. Furthermore, we performed a structure–uptake relationship study with 13 DABCYL derivatives coupled to CPP to examine their effect on the cell‐uptake efficiency when conjugated to mono‐Ub through disulfide linkages. Our results show that through structure variations of the DABCYL moiety alone we could reach, at nanomolar concentration, an additional threefold increase in the cytosolic delivery of Ub, which will enable studies on various intracellular processes related to Ub signaling.
High‐Entropy Prussian Blue Analogues and Their Oxide Family as Sulfur Hosts for Lithium‐Sulfur Batteries
Authors: Du Meng , Geng Pengbiao , Pei Chenxu , Jiang Xinyuan , Shan Yuying , Hu Wenhui , Ni Lubin , Pang Huan 
Published: August 2022

AbstractThe introduction of high‐entropy into Prussian blue analogues (PBAs) has yet to attract attention in the field of lithium‐sulfur battery materials. Herein, we systematically synthesize a library of PBAs from binary to high‐entropy by a facile coprecipitation method. The coordination environment in PBAs is explored by X‐ray absorption fine structure spectroscopy, which together with elemental mapping confirm the successful introduction of all metals. Importantly, electrochemical tests demonstrate that high‐entropy PBA can serve as polysulfide immobilizer to inhibit shuttle effect and as catalyst to promote polysulfides conversion, thereby boosting its outstanding performance. Additionally, a variety of nanocubic metal oxides from binary to senary are fabricated by using PBAs as sacrificial precursors. We believe that a wide range of new materials obtained from our coprecipitation and pyrolysis methodology can promote further developments in research on PBA systems and sulfur hosts.
Dual‐exterior surface modification of layered double hydroxides and its application in flame retardant biobased poly(trimethylene terephthalate)
Authors: Wang Kunyan , Zhu Hongtao , Zheng Shaobin , Guo Yuhua , Tang Peisong , Ding Yangbin , Jia Wenzhi , Pan Guoxiang , Guo Qipeng 
Published: August 2022

AbstractThe overall target of this research was to design a dual‐exterior surface chemical modification of eco‐friendly layered double hydroxides (LDH‐S@PA) using calcium stearate and phytic acid (PA) containing‐rich phosphorus to synchronously boost the dispersibility in the polymer matrix and the flame retardancy. Microstructure, surface chemical environments and morphologies of LDH‐S@PA were characterized. It was found that the target product with the hydrophobic surface was successfully prepared. The basic morphologies of LDH‐S@PA exhibited thin flat crystals composed of multi‐sheet with hexagonally arranged spots. Meanwhile, the thermal stability of LDH‐S@PA was improved. Significantly, after adding LDH‐S@PA into biobased poly(trimethylene terephthalate) (PTT) via melting‐blending, LDH‐S@PA exhibited a higher dispersity in the PTT matrix and the PTT/LDH‐S@PA composite with 20 wt% loading achieved 29.8% limiting oxygen index value and possessed V‐0 rating in UL‐94 test, revealing LDH‐S@PA dramatically enhanced the flame retardancy of the PTT. The flame retarded mechanism of LDH‐S@PA in PTT was discussed based on gaseous and condensed phase analysis. In addition, the incorporation of LDH‐S@PA improved the mechanical properties of the composites. This facile and straightforward approach for dual‐surface modification LDHs holds promise as flame retardant formulations for polymer in future applications.
“From the ground up”: Psychoanalytic perspectives on a new system for structuring hospital and clinic care
Authors: Lazes Peter , Rudden Marie 
Published: August 2022

AbstractLabor‐Management Partnerships, a new system for structuring hospital care, are based on the recognition that hospitals are complex organizations requiring multiple levels of communication and exchange, and on the premise that front‐line workers are best able to identify and pose solutions to problems in their units and departments. They are structured to form creative problem‐solving teams of managers and staff supported in their work together to improve their hospital within both in individual areas and systemically. Four extensive examples of such teams are provided from two different hospital settings, one public and one not‐for‐profit. Their work is then assessed through the lens of organizational and group psychoanalytic theories.
Facile Fabrication of Lignin‐Cellulose Green Nanogels
Authors: Sathasivam Thenapakiam , Hu Lixuan , Sugiarto Sigit , Dou Qingqing , Zhang Zheng , Ru Tan Hui , Leow Yihao , Zhu Qiang , Ken Lee Chi‐Lik , Yu Hai‐Dong , Kai Dan 
Published: August 2022

AbstractThere has been increasing exploration of the development and production of biodegradable polymers in response to issues with petrol‐based polymers and their impact on the environment. Here we report a new approach to synthesize a natural nanogel from lignin and nanocellulose. First, lignin nanobeads were synthesized by a solvent‐shifting method, which showed a spherical shape with a diameter of 159.7 nm. Then the lignin nanobeads were incorporated into a nanocellulose network to form the lignin/cellulose nanogels. The nanocellulose fibrils (CNF−C) nanogels reveal a higher storage modulus than the nanocellulose crystal (CNC−C) ones due to the denser network with self‐entanglement of longer cellulose chains. The presence of lignin nanobeads in the nanogels helped to increase the viscoelasticity of the nanogels. This work highlights that the new kinds of green nanogels could be potentially utilized in a variety of biomedical applications such as drug delivery and wound dressing.
Designing acceptance single sampling plans: An optimization‐based approach under generalized beta distribution
Authors: Facchinetti Silvia , Osmetti Silvia Angela , Magagnoli Umberto 
Published: August 2022

AbstractThe availability of information that suppliers possess about the production process, as well as about the technical and economic consequences for customers, encourages the development and application of acceptance sampling plans that follow economic criteria, such as the Bayesian ones proposed in the literature. The combination of prior knowledge described by the prior distribution and empirical knowledge based on the sample leads to the decision to accept or reject the lot under inspection. The main purpose of this study was to derive acceptance sampling plans for attributes based on a prior generalized beta distribution following the economic criterion to minimize the expected total cost of quality. Specifically, a procedure is proposed to define the optimal sampling plan based on the technical characteristics of the production process and the costs inherent in the quality of the product. After the methodological aspects are described in detail, an extensive simulation study is reported that demonstrates how the optimal plan changes according to the main parameters, providing guidance for practitioners.
Duktilitätssteigernde Bewehrungssysteme für fließgefertigte Stabelemente aus UHFB
Authors: Markowski Jan , Meyer Max , Haist Michael , Lohaus Ludger 
Published: August 2022

AbstractUm schneller, leichter und präziser mit Beton bauen zu können, wurde ein neues, modulares Baukonzept auf Basis ultrahochfester Betone (UHFB) erforscht und entwickelt, das ein besonders vorteilhaftes Verhältnis von Axialdrucktragfähigkeit und Eigengewicht aufweist [1]. Um dieses, als wickelverstärktes UHFB‐Hybridrohr bezeichnete Stabelement in einem automatisierten Strangpressverfahren fertigen zu können, muss ein neuartiges Bewehrungskonzept ohne übliche Stahlbewehrung entwickelt werden. Im Extrusionsprozess wird ein stützendes inneres Stahlrohr im Strangpressverfahren mit UHFB ummantelt und zusammen mit dem UHFB vorgeschoben. Anschließend wird eine duktilitätssteigernde Umschnürungsbewehrung in einem automatisierbaren Verfahren von außen auf die Oberfläche der Bauteile appliziert. Da im Versagensfall UHFB‐Bruchstücke die CFK‐Bewehrung schädigen, wird in diesem Aufsatz untersucht, mit welchem Schutzschicht/Bewehrungssystem ein duktiles Bauteilverhalten für axialdruckbeanspruchte Stabtragwerke erreicht werden kann. Dazu wurden unterschiedliche textile Bewehrungsschichten auf UHFB‐Probekörper appliziert und ihr Einfluss auf das Tragverhalten der Bauteile unter besonderer Berücksichtigung der Duktilität und Resttragfähigkeit nach Überschreiten der Maximallast ermittelt. Eine Kombination aus Aramidgewebe und Kohlenstofffasergelege zeigte in experimentellen Untersuchungen ein günstiges Tragverhalten mit quasiduktilem Verformungsvermögen.
Sulfono‐γ‐AApeptides as Protein Helical Domain Mimetics to Manipulate the Angiogenesis
Authors: Xue Songyi , Wang Lei , Cai Jianfeng 
Published: August 2022

AbstractSulfono‐γ‐AApeptides recently developed in our group have been proven to be a new class of unnatural foldamer with well‐defined helical structure and have been demonstrated to mimic protein helical domains and disrupt biomedically relevant protein‐protein interactions (PPIs). Based on our design concept in a recent report, we discovered two similar sulfono‐γ‐AApeptides V2 and V3 which were designed to mimic the VEGF N‐terminal helix α1 known to directly interact with VEGFRs. Interestingly, V2 was shown to possess the pro‐angiogenic effect, whereas V3 was proved to be a potent inhibitor for angiogenesis. We speculate that the distinct angiogenesis signaling was due to the selective binding of the two molecules to VEGFR1 and VEGFR2, respectively. Together with their remarkable resistance to proteolytic degradation, relatively small sizes, and amenability to modification with diverse functional groups, V2 and V3 could serve as lead molecules for the development of potential therapeutic agents and molecular probes. These findings highlight sulfono‐γ‐AApeptides as an alternative paradigm to mimic the α‐helical domain to modulate a wide variety of PPIs in the future.
Potential G‐quadruplexes within the Promoter Nuclease Hypersensitive Sites of the Heat‐Responsive Genes in Rice
Authors: Chang Tianjun , Li Guangping , Ding Zhan , Li Weiguo , Zhu Panpan , Lei Wei , Shangguan Dihua 
Published: August 2022

AbstractG‐quadruplexes (G4s) have been shown to be involved in the regulation of multiple cellular processes. Exploring putative G4‐forming sequences (PQSs) in heat‐responsive genes of rice and their folding structures under different conditions will help to understand the mechanism in response to heat stress. In this work, we discovered a prevalence of PQSs in nuclease hypersensitive sites within the promoters of heat‐responsive genes. Moreover, 50 % of the searched G3 PQSs ((G3+L1‐7)3+G3+) locate in heat shock transcription factors. Circular dichroism spectroscopy, thermal difference spectroscopy, and UV melting analysis demonstrated the representative PQSs could adopt stable G4s at physiological temperature and potassium concentration. These PQSs were able to stall Klenow fragment (KF) DNA polymerase by the formation of G4s. However, the G4s with Tm values around 50–60 °C could be increasingly unwound by KF with the increase of temperatures from 25 to 50 °C, implying that these G4s could sense the changes in temperature by structural switch. This work offers fresh clues to understanding the potential of G4‐involved functions of PQSs and the molecular events in plants in response to heat stress.
A‐Site Substitution Motivating the Phase Transformation of LaNiO3 Perovskite for High‐Performance Artificial N2 Fixation
Authors: Zheng Yinan , Zhang Shishi , Yao Hu , Li Xue , Su Yaqiong , Guo Xiaohui 
Published: August 2022

AbstractElectrocatalytic N2 reduction reaction (NRR) to NH3 under ambient conditions is an attractive strategy compared to the traditional Haber‐Bosch process. However, there still remains a great challenge due to the high activation barrier of N2 and consequent sluggish kinetics. Herein, A‐site substitution of LaNiO3 perovskites by Sr‐doping is proposed which can lead to phase transformation and to the formation of oxygen vacancies, significantly improving the NRR performance of La1‐xSrxNiO3 (LSNO). The appropriate oxygen vacancy concentration can be modulated by changing the stoichiometric ratio of La and Sr elements. LSNO‐III (x=0.5) delivers the highest ammonia production rate of 55.9 μg h−1 mg−1cat. at −0.7 V and Faraday efficiency of 23.17 % at −0.5 V versus the reversible hydrogen electrode in 0.1 M Na2SO4. Density functional theory (DFT) calculations further demonstrate that introduction of oxygen vacancies decreases the distance of the d‐band center to the Fermi energy level, which not only facilitates adsorption and activation of N2 molecules and subsequent hydrogenation reactions, but also further optimizes reaction pathways in NRR.
The Sulfur Rich Fluorothiophosphate Dianions [S5P2F2]2− and [S3PF]2− : Cluster and Chelation Control of P‐S Heterolysis
Authors: Gaydon Quentin , Bohle David Scott 
Published: August 2022

AbstractThe sulfur rich difluoropentathiodiphosphate dianion [S5P2F2]2−, from fluoride addition to P4S10, has a somewhat checkered history and proves to be the main product of the reaction in acetonitrile. Its optimized synthesis, and structural characterization, as either a tetraphenylphosphonium or a tetrapropylammonium salt, [NnPr4]2[S5P2F2] allows for the first coordination chemistry for this dianion. Reactions of [S5P2F2]2− with d10 metal ions of zinc(II), and cadmium(II), and d9 copper(II) resulted in a surprising diverse array of binding modes and structural motifs. In addition to the simple bis‐chelate coordination of [S5P2F2]2− with zinc, cleavage of the P−S bond resulted in complexes with the unusual [S3PF]2− fluorotrithiophosphate dianion. This was observed in two cluster complexes: a trinuclear cadmium complex with mixed [S5P2F2]2−/[S3PF]2− ligands, [Cd3(S5P2F2)3(S3PF)2]4− as well as an octanuclear copper cluster, [Cu8(S3PF)6]4− which form rapidly at room temperature. These new metal/sulfur/ligand clusters are of relevance to understanding multimetal binding to metallothionines, and to potential capping strategies for the condensed nanoparticulate cadmium chalcogenide semiconductors CdS and CdSe.
A Chemotactic Colloidal Motor
Authors: Zhou Chang , Yang Ling , Wu Yingjie , Yang Mingcheng , He Qiang 
Published: August 2022

AbstractChemotaxis plays a crucial role in the realization of various functions of human life such as fertilization, immune function, inflammatory response, regeneration processes, etc. Inspired by the natural chemotaxis, colloidal motors with chemotactic ability can realize intelligent sense and targeted navigation, which bring a revolutionary method to biomedical applications like precision medicine. However, the application in the biomedical field requires the colloidal motors with submicrometer scale, strong chemotactic ability and clear chemotactic mechanism. In this Concept article, we introduce the recent progress of chemotactic colloidal motors, covering the fundamental theory behind experimental advancements. Particularly, the torque‐driven reorientation motion of the submicrometer‐sized colloidal motors during chemotaxis is discussed, and also their underlying mechanism is proposed. With the continuous research on chemotactic colloidal motors, it is believed that the emerging chemotactic colloidal motors will broaden practical applications in the biomedical field.
How Water and Ion Mobility Affect the NMR Fingerprints of the Hydrated JBW Zeolite: A Combined Computational‐Experimental Investigation
Authors: Vanlommel Siebe , Hoffman Alexander E. J. , Smet Sam , Radhakrishnan Sambhu , Asselman Karel , Chandran C. Vinod , Breynaert Eric , Kirschhock Christine E. A. , Martens Johan A. , Van Speybroeck Veronique 
Published: August 2022

AbstractAn important aspect within zeolite synthesis is to make fully tunable framework materials with controlled aluminium distribution. A major challenge in characterising these zeolites at operating conditions is the presence of water. In this work, we investigate the effect of hydration on the 27Al NMR parameters of the ultracrystalline K,Na‐compensated aluminosilicate JBW zeolite using experimental and computational techniques. The JBW framework, with Si/Al ratio of 1, is an ideal benchmark system as a stepping stone towards more complicated zeolites. The presence and mobility of water and extraframework species directly affect NMR fingerprints. Excellent agreement between theoretical and experimental spectra is obtained provided dynamic methods are employed with hydrated structural models. This work shows how NMR is instrumental in characterising aluminium distributions in zeolites at operating conditions.
Autosomal recessive hyper‐IgE syndrome due to DOCK8 deficiency: An adjunctive role for omalizumab
Authors: Nguyen Kim Han , Nguyen Quynh Anh , Tran Mai Hoang , Can Thu Thuy , Vu Mai Thi , Vo Nam Sy , Chi Hieu Chu , van Nunen Sheryl , Van Nguyen Dinh 
Published: August 2022

AbstractAutosomal recessive hyper‐IgE syndrome (AR‐HIES) is a rare primary immunodeficiency disorder characterized by high serum IgE levels, recurrent viral skin infections, severe allergies, and early‐onset malignancies, associated with mutations in the gene encoding the dedicator of cytokinesis 8 protein (DOCK8). We report a rare case of AR‐HIES with DOCK8 deficiency in a young Japanese male with a past medical history of chronic atopic dermatitis, severe food allergies, and severe herpes simplex virus infection. Treatment was successfully based on infection management, skincare, and dietary elimination. In addition, anti‐IgE therapy with omalizumab was the target treatment for this syndrome.
A novel optimized intelligent green signal timing system for urban corridor
Authors: Malathi Narra , Kumar Molugaram 
Published: August 2022

SummaryIn the real world, fixed traffic time signal control is commonly used due to the low implementation cost. However, these signal systems do not achieve the best performance, especially when the unbalanced traffic demand. Hence, a novel buffalo based recurrent fuzzy green timing system (BRFGTS) is proposed to enhance the green timing. Moreover, traffic speed data was initially collected to implement the proposed model. Consequently, after neural layer training, the preprocessing was performed to eliminate the unwanted data. After that, feature extraction is done to take the required features from the preprocessed data. After extracting the features, the data are moved through the classification process. A recurrent network‐based approach trains the data in the classification process. Furthermore, the fitness of buffalo is updated in the classification layer of the recurrent model to reduce the traveling time by improving the shortest route prediction to identify the other path to travel vehicle. The proposed green timing system is implemented in the tool named MATLAB. Subsequently, the results from the proposed model are compared with different techniques. Thus the recorded minimum traveling time by the presented BRFGTS is 20.5 s; compared to other models, it has minimized the traveling time by 40%. Also, the proposed model has minimized the queue length by 38% than the compared models. Hence, the robustness of the novel BRFGTS has been proved.
Isolation and Culture of Vascular Distal Outflow Pathway (VDOP) Cells From Human Donor Eyes
Authors: Roy Chowdhury Uttio , Fautsch Michael P. 
Published: August 2022

AbstractGlaucoma, a progressive neurodegenerative ocular disease, is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is the most common—and the only treatable—risk factor for glaucoma. IOP is generated by the balance between production and removal of aqueous humor in the anterior part of the eye, and the latter happens either through the uveoscleral or the conventional pathway. Although both pathways are important for aqueous humor removal, dysfunction within the conventional pathway is more commonly associated with increased resistance leading to elevated IOP and glaucoma. The conventional pathway can be separated into proximal (trabecular meshwork and inner wall of Schlemm's canal) and distal (outer wall of Schlemm's canal, collector channels, and episcleral vasculature) regions. Both regions contribute resistance to aqueous humor removal, but the proximal region has been studied more extensively due to the availability of model systems. In contrast, little is known about the role of the distal region in outflow resistance, largely due to the lack of suitable in vitro models. To address this, we have developed a novel method of isolating and culturing vascular distal outflow pathway (VDOP) cells from the distal outflow region of human eyes. VDOP cells can be used to study the physiological and molecular functions of cells in the distal outflow region and can help in the development of ocular hypotensive drugs that specifically target this area. We also provide a protocol describing immunohistochemical methods to validate the molecular profile of these cells, utilizing cell surface markers that distinguish them from adjacent cells. © 2022 Wiley Periodicals LLC.Basic Protocol 1: Isolation and culture of VDOP cellsBasic Protocol 2: Analysis of cell surface markers