bluuebunny/crossref_metadata_2025_split huggingface dataset:
Person-Centered Care Research in Ghana: a Scoping Review Protocol
Authors: Amoh Gordon , Addo Alex Kweku , Odiase Osamuedeme , Tahir Peggy , Getahun Monica , Aborigo Raymond , Essuman Akye , Yawson Alfred E , Essuman Vera Adobea , Afulani Patience A 
Published: June 2022

Abstract
Background: Person-centered care (PCC) is provision of care that is respectful of and responsive to in­dividual patient preferences, needs, and values, and ensures that patient values guide all clinical decisions. While there is a large body of evidence on the benefits of PCC in high-income countries, little research exists on PCC in Ghana and Sub-Saharan Africa at large. Most studies on PCC have focused on maternity care as part of the global movement of respectful maternity care. The few studies on patient experiences and health system responsiveness beyond maternal health also highlight gaps in patient experience and satisfaction, as well as discrimination in health facilities which leads to the most vulnerable having the poorest experiences. This scoping review aims to systematically map the extent of literature focused on PCC in Ghana by identifying patient expectations and preferences, barriers and facilitators, and interventions regarding PCC in Ghana.Methods: This protocol will be guided by the Arksey and O’Malley methodological framework and recommendations by Levac, Colquhoun and O'Brien. A comprehensive search strategy will be used to search for published articles in PubMed, EMBASE, Web of Science, and the African Journals Online (AJOL) from their inception to December 2021. Grey literature and reference lists of included studies will also be searched. Two independent reviewers will perform the literature search, eligibility assessments, and study selection. Any disagreements will be resolved through discussion with a third reviewer. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram for the scoping reviews (PRISMA-ScR) will be used to outline the study selection process. Extracted data from the included articles will be synthesised and reported under key concepts derived from the outcomes of the scoping review.Discussion: The findings from this proposed scoping review on documented person-centeredness of care and patient expectations and preferences regarding PCC will be useful information for policymakers to consider in rolling out healthcare strategies that are driven by patient interest. Also, identification of various barriers and facilitators and evidence of effective PCC interventions will have implications on policy, practice, and further research in Ghana.Scoping review registration: OSF Registration DOI 10.17605/OSF.IO/ZMDH9
Pilonidal cyst with malignant degeneration: a case report
Authors: Bonilla Sergio Cervera , Marin Manuela Ramirez , Buendia Margarita Tamayo , Cortes Maddy Mejia , Gonzalez Rocio Mariño , Lopez Liliana Cuevas 
Published: June 2022

Abstract
Introduction: Pilonidal cyst is a frequent surgical pathology with low risk of malignancy. Here, we present a case of a chronic pilonidal cyst with transformation to skin squamous cell carcinoma. Case presentation: A 67-year-old male patient with a chronic presentation of injury in the sacrococcygeal region with occasional bleeding that got worse with progressive growth and purulent discharge. Initially was treated as a soft tissue infection with oral antibiotics but did not solve. A skin biopsy reported a squamous cell carcinoma, extension studies showed no secondary disease of the lesion. The patient was treated as if he was diagnosed a squamous cell carcinoma of the anal margin. Treatment was initiated with Nigro protocol chemoradiotherapy and wide local resection of the lesion with oncological margins of 1 cm with success.Discussion: The pilonidal cyst is an episodic inflammatory disease in the sacrococcygeal zone that usually responses to antibiotic treatment and surgery if it’s necessary, malignant degeneration is rare, might it be related with chronic inflammation that affects repair mechanisms and create a predisposition for malignancy. The optimal treatment is in bloc surgical resection with tumor-free margins and complementary treatment depends on the histology.Conclusion: This is an uncommon case of a Pilonidal cyst with transformation to skin squamous cell carcinoma managed with Nigro protocol chemoradiotherapy and wide local resection. This case will give surgeons another tool to treat this condition.
Arrhenius equation construction and nitrate source identification of denitrification at the Lake Taihu sediment−water interface with 15N isotope
Authors: Ma Qiuxia , Pang Min , Pang Yong , Zhang Lu , Huang Zhilin 
Published: June 2022

Abstract
Total nitrogen in Taihu Lake, China has gradually decreased since 2015 while the total phosphorus concentration has exhibited an increasing trend, indicating an asynchronous change. The dominant nitrogen removal process in freshwater ecosystems is denitrification which primarily occurs at the sediment–water interface. In this study, 15N isotope incubation experiments were attempted to analyze the effect of water temperature on denitrification, to construct the regional denitrification Arrhenius equations considering water temperature, and to identify the nitrate source of denitrification in Lake Taihu sediments. The results indicated that the potential N2 production rates and denitrification rates generally decreased in the west to east direction, which was significantly positively correlated with the nitrate concentration of overlying water by Pearson correlation coefficient analysis (P < 0.05). In addition, when the water temperature was lower than 30°C, the rates of the potential N2 production and denitrification were higher with an increase in water temperature, but when the water temperature was overhigh, denitrification was inhibited. The ratio of the total denitrification rate of nitrate from the water column in the sediment to the total denitrification rate during the incubation experiment was above 0.5 at each sampling site. This indicated that the denitrification in the Lake Taihu sediment primarily occurred at the expense of nitrate from the water column. The research results of Arrhenius equation construction and nitrate source identification of denitization can be applied to improve the accuracy of water quality model of Taihu Lake, which is of great significance to improve Taihu Lake water quality, and can act as a reference for the water environment treatment of other shallow eutrophic lakes in China and abroad.
Antibiotic allergy and blood eosinophils percent could be prognostic indicators of glioma
Authors: SUN QIAN , Cao Liming , WANG HUAN , Wang Weiliang , Li Xue , Shi Jing , Liang Hongsheng , Zhang Yiwei , Lv Zhonghua 
Published: June 2022

Abstract
Introduction: To estimate the effect of antibiotic allergy and blood eosinophil percentage (EOS%) on glioma prognosis and to conduct a nomogram model for glioma patients.Methods: We conducted a retrospective cohort study with 656 glioma patients to estimate the associations between antibiotic allergy, EOS% and glioma prognosis by Kaplan-Meier and Cox regression analysis. Stratified analyses were performed according to tumor grade. We constructed a nomogram with age at diagnosis, gender, tumor grade, antibiotic allergy, EOS% to predict the survival probabilities of glioma.Results: During 12 months follow-up, a total of 227 patients were alive and 318 patients died. Antibiotic allergy and EOS% >1.65 conferred a survival advantage on glioma patients. In the stratified analysis by tumor grade, antibiotic allergy was significantly associated with the prognosis of the prognosis of low-grade gliomas (HR = 0.36, 95%CI: 0.13–0.97) and high-grade gliomas (HR = 0.58, 95%CI: 0.36–0.93) in the univariate Cox regression analysis. However, after adjusting for confounding factors in the multivariate Cox regression analysis, antibiotic allergy was only significantly associated with high-grade gliomas (HRadj = 0.50, 95%CI: 0.30–0.82); the relationship between EOS% and glioma prognosis was restricted to low-grade gliomas (HRadj = 0.50, 95%CI: 0.30–0.82). The C-index of nomogram was 0.74.Conclusion: Antibiotic allergy was a protective prognosis factor of high-grade gliomas, EOS% >1.65 was a protective prognosis factor of low-grade gliomas. The nomogram with antibiotic allergy and EOS% could effectively predict the survival probability of glioma.
Influence of the direct and indirect effects of landscape fragmentation, via microclimate change, on animal locomotion
Authors: Tigreros Natasha , Kozhoridze Giorgi , Davidowitz Goggy , Ziv Yaron 
Published: June 2022

Abstract
Context Intensive use of agricultural land often modifies the landscape by dividing continuous natural habitat into smaller and more isolated patches. While it is widely recognized that landscape fragmentation is a main cause of species extinction, less is known about how this impacts the function of organisms that do persist in the modified environment. Understanding these effects is complicated by the fact that fragmentation can affect organisms directly but also indirectly, by altering the patch microclimatic conditions. Objectives We tested the hypothesis that fragmentation-induced microclimate change might be an important mechanism driving changes in animal locomotion in an agricultural landscape. Methods We used satellite image analysis, behavioral assays, and patch analyses, to disentangling the direct and indirect effects of fragmentation on the locomotor behavior of a darkling beetle, Zophosis punctata (Tenebrionidae), in the Southern Judea Lowlands in Israel. Results We found that fragmentation in an agricultural ecosystem may lead to changes in the thermal conditions of natural habitat patches. Importantly, such fragmentation-related increases in patch temperature played an important role in explaining variation in beetle locomotion across an agricultural landscape. Specifically, beetles from highly fragmented landscapes, which included warmer habitat patches, showed high locomotor intermittence –frequent pausing events during locomotion. Conclusions This study shows that the potential consequences of landscape fragmentation on the organism function are likely to be underestimated when fragmentation-related microclimate change is ignored. Intermittent locomotion, as opposite to steady locomotion, may provide various physiological and fitness benefits in fragmented landscapes, like mitigating performance limitations imposed by extreme thermal conditions.
Facilitators and Barriers to the Implementation of New Critical Care Practices during COVID-19: A Multicenter Qualitative Study using the Consolidated Framework for Implementation Research (CFIR)
Authors: Silver Santana , Jones Kayla Christine , Redmond Sarah , George Emily , Zornes Sarah , Barwise Amelia , Leppin Aaron , Dong Yue , Harmon Lori A. , Kumar Vishakha K. , Kordik Christina , Walkey Allan , Drainoni Mari-Lynn 
Published: June 2022

Abstract
Background
The COVID-19 pandemic produced unprecedented demands and rapidly changing evidence and practices within critical care settings. The purpose of this study was to identify factors and strategies that hindered and facilitated effective implementation of new critical care practices and policies in response to the pandemic.
Methods
We used a cross-sectional, qualitative study design to conduct semi-structured in-depth interviews with critical care leaders across the United States. The interviews were audio-taped and professionally transcribed verbatim. Guided by the Consolidated Framework for Implementation Research (CFIR), three qualitative researchers used rapid analysis methods to develop relevant codes and identify salient themes.
Results:
Among the 17 hospitals that agreed to participate in this study, 31 clinical leaders were interviewed. The CFIR-driven rapid analysis of the interview transcripts generated 12 major themes, which included six implementation facilitators (i.e., factors that promoted the implementation of new critical care practices) and six implementation barriers (i.e., factors that hindered the implementation of new critical care practices). These themes spanned the five CFIR domains (Intervention Characteristics, Outer Setting, Inner Setting, Characteristics of Individuals, and Process) and 11 distinct CFIR constructs. Salient facilitators to implementation efforts included staff resilience, commitment, and innovation, which were supported through collaborative feedback and decision-making mechanisms between leadership and frontline staff. Major identified barriers included lack of access to reliable and transferable information, available resources, uncollaborative leadership and communication styles.
Conclusions:
Through applying the CFIR to organize and synthesize our qualitative data, this study revealed important insights into implementation determinants that influenced the uptake of new critical care practices during COVID-19. As the pandemic continues to burden critical care units, clinical leaders should consider emulating the effective change management strategies identified. The cultivation of streamlined, engaging, and collaborative leadership and communication mechanisms not only supported implementation of new care practices across sites, but it also helped reduce salient implementation barriers, particularly resource and staffing shortages. Future critical care implementation studies should seek to capitalize on identified facilitators and reduce barriers.
Identification of Arsenic Spatial Distribution by Hydrogeochemical Processes Represented by Different Ion Ratios in the Hohhot Basin, China
Authors: Ren Yu , Cao Wengeng , Li Zeyan , Pan Deng , Wang Shuai 
Published: June 2022

Abstract
The Hohhot Basin, a typical inland basin of the Yellow River Basin in China, generally has high concentrations of arsenic (As) in its shallow groundwater, while the factors dominating the distribution of high arsenic levels remain to be further identified. An analysis of the ratio of hydrogeochemical compositions can help to reveal the spatial characteristics of the shallow groundwater environmental conditions and the distribution of high arsenic water (As > 10µg/L). In this study, a total of 170 samples of shallow groundwater in the Hohhot Basin were collected and water samples with As > 10µg/L accounted for 29.4% of the total. Based on the slope changes of the cumulative frequency curves of (HCO3−+CO32−)/SO42−, Ca2+/(HCO3−+CO32−), Ca2+/Mg2+ and Na+/Ca2+, the groundwater in the study area can be categorized into six different zones according to the environmental characteristics including redox condition, surface water recharge intensity and cation exchange level. The result shows that the groundwater in the front of the piedmont alluvial plain and platform is in a weak reducing condition with high lateral recharge intensity, fast runoff, and weak cation exchange. In the Dahei River alluvial plain, which serves as the groundwater discharge zone, the groundwater runoff is sluggish with poor lateral recharge, sufficient exchange between cations in the groundwater and the aquifer matrix, and enhanced reducibility. The degree of oxidation increased in the groundwater near the Hasuhai Lake and the drainage canal, which adverse to the arsenic enrichment. High arsenic groundwater is mainly distributed in aquifers of (HCO3−+CO32−)/SO42 > 10, Na+/Ca2+>13, and Ca2+/(HCO3−+CO32−) < 0.1, which represent the strong reducing condition, low surface water recharge intensity and strong cation exchange condition. Reductive dissolution of iron oxide, strong evaporation and concentration process, and competition from phosphate in aquifers jointly lead to the release of arsenic into groundwater.
A genome-wide screen reveals new regulators of the 2-cell-like cell state
Authors: Defossez Pierre-Antoine , Gupta Nikhil , Yakhou Lounis , Albert Julien Richard , Miura Fumihito , Ferry Laure , Kirsh Olivier , Azogui Anaelle , Yamaguchi Kohsuke , Laisné Marthe , Domrane Cécilia , Bonhomme Frédéric , Sarkar Arpita , Delagrange Marine , Ducos Bertrand , Cristofari Gael , Ito Takashi , Greenberg Maxim 
Published: June 2022

Abstract
In mammals, only the zygote and blastomeres of the early embryo are fully totipotent. This totipotency is mirrored in vitro by mouse "2-cell-like cells" (2CLCs), which appear at low frequency in cultures of Embryonic Stem cells (ESCs). Because totipotency is incompletely understood, we carried out a genome-wide CRISPR KO screen in mouse ESCs, searching for mutants that reactivate the expression of Dazl, a robust 2-cell-like marker. Using secondary screens, we identify four mutants that reactivate not just Dazl, but also a broader 2-cell-like signature: the E3 ubiquitin ligase adaptor SPOP, the Zinc Finger transcription factor ZBTB14, MCM3AP, a component of the RNA processing complex TREX-2, and the lysine demethylase KDM5C. Functional experiments show how these factors link to known players of the 2 cell-like state. These results extend our knowledge of totipotency, a key phase of organismal life.
Interactions between carbon nanotubes and external structures of SARS-CoV-2 using molecular docking and molecular dynamics
Authors: Lobato Júlio Cesar Mendes , Arouche Tiago da Silva , Nero Jordan Del , Filho Tarciso Andrade , Borges Rosivaldo dos Santos , Neto Antonio Maia de Jesus Chaves 
Published: June 2022

Abstract
Molecular modeling techniques are used to describe the process of interaction between nanotubes and the main structures of the Covid-19 virus: the envelope protein, the main protease, and the Spike glycoprotein. Molecular docking studies show that the ligands have interaction characteristics capable of adsorbing the structures. Molecular dynamics simulations provide information on the mean squared deviation of atomic positions ​​between 0.5 and 3.0 Å. The Gibbs free energy model and solvent accessible surface area approaches are used. Through the results obtained through molecular dynamics simulations, it is noted that the zigzag nanotube prefers to interact with E-pro, M-pro, and S-gly, respectively. Molecular couplings and free energy showed that the S-gly active site residues strongly interact with zigzag, chiral, and armchair nanotubes, in this order. The interactions demonstrated in this manuscript may predict some promising candidates for virus antagonists, which may be confirmed through experimental approaches.
How surface acting affects turnover intention among family doctors in rural China: The mediating role of emotional exhaustion and the moderating role of occupational commitment
Authors: Wang Anqi , Tang Changhai , Zhou Lifang , Lv Haiyuan , Song Jia , Chen Zhongming , Yin Wenqiang 
Published: June 2022

Abstract
Background: Family doctors in rural China are the main force for primary health care. It is critical to stabilize the Chinese healthcare system and improve the quality of primary health care by understanding family doctors’ turnover intention. Surface acting is an important strategy of emotional labor, and few studies have focused on the effect of emotional labor on turnover intention among family doctors. The aim of this study with Conservation of Resources theory is to explore how the surface acting of family doctors in rural areas affects turnover intention through emotional exhaustion and to investigate what role occupational commitment plays in this relationship.Methods: 953 valid data were collected by an anonymous self-administered questionnaire survey in December 2021 in Shandong Province, China. Cronbach’s α and confirmatory factor analysis (CFA) were used to estimate reliability and structural validity, respectively. The PROCESS macro in SPSS was performed to analyze mediating and moderated mediation effects of surface acting, emotional exhaustion, occupational commitment, and turnover intention.Results: Reliability and validity indicated that measurement instruments were acceptable. Surface acting had a direct positive effect on turnover intention (β= 0.481, 95%CI: [0.420, 0.543]). Emotional exhaustion partially mediated the effect of surface acting on turnover intention (indirect effect: 0.214, 95%CI: [0.175, 0.256]). Occupational commitment moderated the effect of emotional exhaustion on turnover intention (β= -0.065, 95%CI: [-0.111, -0.019]), and moderated the indirect effect of surface acting on turnover intention via emotional exhaustion (index of moderated mediation: -0.035).Conclusions: Emotional exhaustion partially mediates the relationship between surface acting and turnover intention among family doctors in rural China, and occupational commitment moderates the direct effect of emotional exhaustion on turnover intention and further moderates the mediating effect. It is suggested that engagement and diversion strategies are used to reduce the practice of surface acting. Also, pre-service education and external resources are provided to increase family doctors’ occupational commitment and minimize the incidence of emotional exhaustion and turnover intention.
Odor Identification Quantitatively by Odorant Receptor Vectors
Authors: Kawai Kosei , Morishita Shin 
Published: June 2022

Abstract
A new concept of odorant receptor vectors composed of the half maximal effective concentration (EC50) of each receptor to odorant molecules was proposed. Odors are mainly subjective and qualitative evaluation has been per-formed until now. Therefore, we attempted to quantitatively express the direct association between odorant receptors and odor molecules in this study. The degree of similarity evaluated by taking inner product of the odorant receptor vectors was verified by comparing with the results by sensory evaluation tests published in past literatures in the form of correlation coefficient. A multi-layered artificial neural network whose input was the elements of prescribed odorant receptor vector was also introduced to identify odorant molecules in the output layer. As a result, the inner product of proposed odorant receptor vector might evaluate the degree of similarity quantitatively among various odorants. Further, it might be possible to identify odorant molecules by the artificial neural network using EC50 of receptors to various odorants.
The Development of an Instructional Model of Holographic Standardized Patient-based Education for Enhancing Clinical Reasoning skill in Undergraduate Healthcare Education
Authors: Kang Yong Joon , KANG YUN , Hong Hyeonmi , Lee Woosuck 
Published: June 2022

Abstract
Objective
The use of holographic standardized patient (HSP) with mixed reality can provide students with the opportunity to enhance clinical reasoning skills. This is still relatively new, so there is a lack of guidelines for educators. Thus, we aimed to develop the instructional model of HSP-based education, for enhancing clinical reasoning skills in undergraduate healthcare education, which could systematically guide educators in designing and implementing HSP-based teaching and learning activities appropriately.
Results
The instructional model developed in this study has six steps: (1) Consider the situation, (2) Collect cues and information, (3) Identify problems and issues with potential causes, (4) Action plan with rationale, (5) Expected outcomes, and (6) Reflection. It includes the teaching and learning activities required in each stage.