bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low-cost Adaptation Options to Support Green Growth in Agriculture, Water Resources, and Coastal Zones
Authors: Salack Seyni , Sanfo Safietou , Sidibe Moussa , Daku Elidaa , Camara Ibrahima , Dieng Mame Diarra Bousso , HIEN Koufanou , Torou Bio Mohamadou , Ogunjobi Kehinde , Sangare Sheick K. , Kouame Konan Raoul , Koffi Yao Bernard , Liersch Stefan , Savadogo Moumini , Giannini Alessandra 
Published: April 2022

Abstract
The current and projected regional climate may strain investments in crop and livestock production systems, fisheries, and other water [natural] resources management in sub-Saharan Africa. Meanwhile, changes in some oceanic parameters across the Atlantic Ocean may lead to remarkably high vulnerability of coastal ecosystem, littorals, and the mangroves towards the mid-21st Century and beyond. Here, we identify the priority needs for adaptation and well-fitted adaptation options, deemed sustainable over the future climate, clean and low-cost in line with the countries' green economic emergence goals. Based on field evidence and customized simulation designs, the cost of these adaptation measures may likely decrease and benefit sustainable green growth in agriculture, water resources management, and coastal ecosystems of West Africa as hydroclimatic hazards grow to include pluviometric and thermal extremes. These adaption actions can be operationalized using sovereign wealth funds of governments, private sector investments, and scaled by global climate funds. However, their effectiveness requires sound policy, knowledge transfer, and relevant partnerships.
The observation of anterior segment in children with corneal dystrophy and an R124L mutation by optical coherence tomography and confocal microscopy
Authors: Zhou Xingtao , Fu Mengjun , Zhao Jing , Zhao Jingjing , Zhang Haorun , Wang Rui 
Published: April 2022

Abstract
Purpose: To evaluate the anterior segment in children with corneal dystrophy (CD) and R124L mutations using optical coherence tomography (OCT) and confocal microscopy.Methods: We investigated a family with prevalent CD and an R124L mutation; 59 individuals (14 patients; six male and eight female, aged 2-69 years, six children, 2:4 male: female ratio) from four generations were included. We observed corneal lesions through ophthalmologic examinations, OCT, and confocal microscopy. The mean follow-up was 4.60±3.91 years.Results: The mean age for childhood CD onset was 0.90±0.61 years. An Avelino DNA test revealed a heterozygous R124L mutation. Clinical manifestations included recurrent photophobia, tearing, and a foreign body sensation. Recurrence frequency decreased with age. Slit lamp microscopy revealed a rough corneal epithelium. The anterior matrix under the corneal epithelium and the anterior elastic layer were scattered with gray and white opacity. From onset to follow-up, the children’s visual acuity decreased from 0.34±0.12 to 0.55±0.17 LogMAR units. OCT showed uneven corneal epithelial thickness. The Bowman’s layer was replaced by abnormal substances in the anterior segment. Corneal deposits became increasingly thicker; the average thickness at the last follow-up was 102.78±10.13 μm. Confocal microscopy revealed uneven and reflective signals in the corneal upper cortex and subepithelium, with unclear boundaries and a loss of normal cell morphology.Conclusion: We report an early age of onset in a family with prevalent CD due to R124L mutations. Anterior OCT is a convenient, quick, and non-contact tool for screening and monitoring the pathological process of corneal dystrophy.
Reveal the Potential Molecular Mechanisms of Simiao Pills in the Treatment of Hyperuricemic Nephropathy Based on Network Pharmacology with Molecular Docking
Authors: Geng Yin-Hong , Yan Jia-Hui , Han Liang , Chen Zhe , Tu Sheng-Hao , Zhang Lin-Qi , Song Chun-Dong , Duan Feng-Yang , Liu Ya-Fei 
Published: April 2022

Abstract
Objective. A network pharmacology integrated molecular docking strategy was used to predict the underlying molecular mechanism of Simiao pills (SMP) in the treatment of hyperuricemic nephropathy (HN). Methods. The active compounds and targets of SMP were screened by TCMSP database. Then, the disease databases such as CTD, DisGeNET, DrugBank, GeneCards, OMIM, TTD and PharmGKB were searched to determine the targets related to HN. STRING and Cytoscape software were applied to analysis and construct PPI network. R software was used to screen common targets, find the core targets of SMP in the treatment of HN, and perform Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis on the core targets, to clarify the core targets and mechanism of action of SMP in the treatment of HN. Finally, active compounds and core targets were selected for molecular docking verification by AutoDock Vina and Pymol software. Results. In this study, 65 related active compounds of SMP, 203 drug-related targets and 91 common targets of SMP and HN were screened. The network suggests that baicalein, kaempferol, quercetin, wogonin, beta-sitosterol and rutaecarpine may be the effective compounds of SMP in the treatment of HN. GO and KEGG pathway enrichment analyses identified the mechanism. Molecular docking revealed that the active compounds in SMP showed strong affinity towards the core protein receptors.Conclusions. SMP has a synergistic mechanism of multi-molecules, multi-targets and multi-pathways in the treatment of HN, which provides a theoretical basis for further exploring the molecular mechanism of SMP in the treatment of HN.
Cerebral Venous Sinus Thrombosis in Immune Thrombocytopenia Patients Treated with Thrombopoietin Receptor Agonist: Case Series and Literature Review
Authors: Teekaput Chutithep , Nadsasarn Angkana , Tanprawate Surat , Soontornpun Atiwat , Thiankhaw Kitti , Wantaneeyawong Chayasak , Teekaput Kanokkarn , Chai-Adisaksopha Chatree 
Published: April 2022

Abstract
Cerebral venous sinus thrombosis is an uncommon adverse event in immune thrombocytopenia (ITP) patients treated with thrombopoietin receptor agonists. We reported two cases of cerebral venous sinus thrombosis after eltrombopag administration. The first case is a 29-year-old ITP woman who recently initiated eltrombopag one month before admission. She presented with progressive headache, visual disturbance, and nausea for six days with unremarkable physical examination except for bilateral optic disc edema. She was treated with enoxaparin and switched to edoxaban when discharged. The second case is a 75-year-old man with a history of vaccine-induced ITP. He was initially treated with dexamethasone and eltrombopag. One month later, he developed acute cerebral venous thrombosis with hemorrhagic infarction in bilateral frontal lobes. Even though he was treated with intravenous heparin, his status was not improved. He received the best supportive care. The pathophysiology of TPO-RAs-associated cerebral venous sinus thrombosis remained unclear but might associate with platelet activation. Careful use and closed monitoring might prevent this event.
Toward a new IDS based on PV-DM (Paragraph Vector-Distributed Memory Approach)
Authors: Asry Chadia El , Douzi Samira , Ouahidi Bouabid El 
Published: April 2022

Abstract
Intrusion detection systems (IDS) have become increasingly important in recent years as a means of assuring network security and eliminating undesirable conduct. Intrusion detection systems (IDSs) are either software applications or hardware devices that monitor network traffic for indications of malicious activity or policy violations. The study offers a detection technique based on feature selection, the Distributed Memory Paragraph Vector (PV-DM), and machine learning clas-sifiers. We evaluated our proposed system using the NSL-KDD and UNSW-NB15 datasets. Experiments with multiclass classification demonstrate the efficacy of our approach, which achieves 98.92 percent accuracy, 98.92 percent precision, 95.44 percent recall, and 96.77 percent F1-score with only four features in NSL-KDD and 82.86 percent accuracy, 84.07 percent precision, 77.70 percent recall, and 80.20 percent F1-score with only six features in UNSW-NB15. Additionally, our proposed approach outperforms the standard LSTM model across the board.
AaCYPdwf, a new growth regulatory cytochrome p450 gene from Artemissia annua
Authors: Rayhan Mahmuda Umme , Islam Tofazzal , Kim Soo-un 
Published: April 2022

Abstract
Artemisia annua L. produces artemisinin (qinghaosu), which is inhibitory against malarial parasite, Plasmodium falciparum . Genetic engineering is thought to be one of the most reasonable approaches to enhance the production of artemisinin by A. annua plant. This study aimed to clone and investigate a growth regulatory cytochrome p450 gene from A. annua . We cloned a cDNA coding growth regulatory gene from A. annua . The gene had high homology with the steroid 23alpha-hydroxylase produced-gene of A. thaliana, Oryza sativa and Zinnia elegans . The full-length cDNA was 1708 bp long, containing an open reading frame of 1443 bp that encodes 480 amino acids. We transformed A. annua plants with the full-length cDNA driven by 35S promoter through Agrobacterium -mediated transformation. To identify the function of the gene, we applied RNAi gene silencing technique. The plants transformed with the full-length cDNA were normal in growth but the plants transformed with RNAi showed extreme dwarfism. The dwarfism in the gene silenced plants was rescued by the application of brassinolide and gibberellin hormones indicating that the mutants were deficient in the synthesis of a growth regulatory gene which we named AaCYPdwf . Phenotypic characteristics of mutant and phylogenetic analysis clustered the AaCYPdwf with other brassinolide producing genes. Our results suggest that AaCYPdwf is a new gene which likely involved in regulation of brassinosteroid biosynthesis in A. annua plants.
Development of high biodegradable sustainable films based on pequi (Caryocar brasiliense) pulp
Authors: Silva Alessandra Oliveira da , Fakhoury Farayde Matta , Fonseca Gustavo Graciano 
Published: April 2022

Abstract
This work aimed to develop films based on pequi (Caryocar brasiliense) pulp added of gelatin and plasticizer (glycerol or sorbitol) and characterize their properties and biodegradation in different soils. The films were presented with a good appearance, easy to handle and with a predominant yellowish color. The greater the addition of plasticizers (3.5%), the greater the elongation and the lower the tensile strength of the films. The higher the gelatin (7%) and the lower plasticizer (1.5%) concentrations, the higher the tensile strength. Thermal analysis allowed to observe a desirable characteristic for packing films: a band between 2Ɵ = 21 ° for both glycerol and sorbitol films, which is present in low crystalline films, reducing the incidence of light in the products. Films were at the most 100% degraded over a period of five to nine days. Thus, the films obtained are recommended to be utilized for food packaging applications.
Occupational exposure to pesticides and safety behavior among Iranian greenhouse farmers
Authors: Bagheri Asghar , Shirzadi Ziba , Sookhtanlou Mojtaba , Shokohian Ali , Bondori Abolmohammad , Damalas Christos 
Published: April 2022

Abstract
Farmers’ behavior in pesticide use is crucial for promoting safety in agriculture, yet little information exists in the literature with regard to greenhouse farmers. This work studied greenhouse farmers’ health symptoms from exposure to pesticides, behavior in using personal protective equipment (PPE), and explained behavior based on risk attitudes, knowledge of hazards of pesticide use, and experience in pesticide handling in Khuzestan province, Iran. Dizziness while preparing the solution and spraying was the most common symptom from pesticide exposure. PPE was used occasionally, most commonly the simple facemask. Most farmers had negative attitudes towards risks of pesticide use, but showed poor knowledge of pesticide risks and high experience of pesticide poisoning when working in the greenhouse. Based on structural equation modelling, the variables of attitude towards pesticide risks, knowledge of pesticides hazards, and experience of pesticide poisoning accounted for 84% of variability of greenhouse farmers’ behavior in PPE use during pesticide use. Knowledge of pesticide risks shaped farmers’ attitudes towards pesticide risk and attitudes towards pesticide risk had the maximum impact on safety behavior in PPE use. Training courses on the health risks posed by pesticide to human are necessary to improve safety behavior of greenhouse farmers.
Determining factors of Neonatal Mortality in Ethiopia: Investigation from the 2019 Ethiopia Mini Demographic and Health Survey
Authors: Sahile Abay , Bekele Dereje , Ayele Habtamu 
Published: April 2022

Abstract
Background: Neonatal mortality is the probability of dying during the first 28 days of life. Of approximately 5 million children who die in the first year of life in the world, about 3 million are within their first 28 days of birth. In Ethiopia, the neonatal mortality rate is high about 37 per 1000 live births, and the factors are not well documented. Then, this study aimed to determine the key factors that have a significant influence on neonatal mortality.Methods: About 5753 neonatal mortality-related data were extracted from Ethiopia Mini Demographic and Health Survey (2019) data. A frequency distribution to summarize the overall data and Binary Logistic Regression to identify the subset of significant risk factors for neonatal mortality were applied to analyze the data.Results: About 36 per 1000 children died before the first 28 days of life with the highest about 15.9% of were in the Benishangul Gumuz region and the lowest about 2.4% of were in ty Addis Ababa. From the Binary logistic regression analysis, the odds ratio and 95% CI of age 25-34 (OR = 0.263, 95% CI: 0.106 - 0.653), Afar (OR= 0.384, 95% CI: 0.167 - 0.884), SNNPR (OR = 0.265, 95% CI: 0.098 - 0.720), Addis Ababa (OR= 5.741, 95% CI: 1.115 - 29.566), Urban (OR = 0.253, 95% CI: 0.090, 0.709), toilet facility (OR= 0.603, 95% CI: 0.404 - 0.900), single birth (OR= 0.261, 95% CI: 0.138 - 0.495), poorest (OR = 10.573, 95% CI: 2.166 - 51.615), poorer (OR = 19.573, 95% CI: 4.171 - 91.848), never breastfed (OR = 35.939, 95% CI: 25.193 - 51.268), public health delivery (OR = 0.302, 95% CI: 0.106 - 0.859), private health facility (OR= 0.269, 95% CI: 0.095 - 0.760). Conclusion: All regional states, specially Benishangul Gumuz, and the Somali region make remedial actions on public health policy, design strategies to improve facilities, and improve the capacities of stakeholders living in their region toward those major factors affecting neonatal mortality in the country.
An Immune-Related Gene Prognostic Index for Bladder Cancer
Authors: Liu Sanhe , Wang Yiqi , Deng Kangli , Huang Lei , Peng Shubin , Wei Shaozhong , Duan Liqun 
Published: April 2022

Abstract
Background
Despite the advances in immunotherapy for bladder cancer in recent years, the efficacy is unsatisfactory as expected. In this study, we have conducted a reliable immune-related gene prognostic index to predict immunotherapy efficacy for bladder cancer based on public databases.
Methods
Differential expression analysis on comparing the tumor and normal samples in the merged TCGA-BLCA & GTEx databases was applied, and the differential expressed immune-related genes were sent to Weighted gene coexpression network analysis. Multivariable Cox analysis of genes among the three most significant coexpression modules was used to develop an immune-related gene prognostic index, and the merged three GEO dataset was used as an independent validation cohort. Further, a model that combined the index with other clinicopathologic features was also verified independently.
Results
11 genes were harvested to construct an immune-related gene prognostic index, both the index and clinicopathologic-index model were well verified in independent cohorts.
Conclusions
The immune-related gene prognostic index for bladder cancer was a reliable and useful marker to predict immunotherapy efficacy for bladder cancer.
Use of dexmedetomidine in patients with sepsis: a systematic review and meta-analysis of randomized-controlled trials
Authors: Zhang Ting , Mei Qimin , Dai Shabai , Liu Yecheng , Zhu Huadong 
Published: April 2022

Abstract
PurposeDexmedetomidine is widely used in patients with sepsis. However, its effect on septic patients remains controversial. Therefore, the objective of this study is to summarize all randomized-controlled trials examining the use of dexmedetomidine in patients with sepsis.MethodsIn this systematic review and meta-analysis, we searched for randomized-controlled trials comparing dexmedetomidine with other sedatives in adults with sepsis. We generated pooled relative risks and mean differences, and performed trial-sequential-analysis as well as cumulative meta-analysis. The primary outcome was mortality, whereas the secondary outcomes were ICU stays, duration of mechanical ventilation and ventilation-free days, incidence of total adverse events, incidence of delirium and levels of IL-6, TNF-α, alanine transaminase.ResultsTwenty-three randomized-controlled trials with 2,293 involved patients were identified. Compared to other sedatives, dexmedetomidine could decrease the all-cause mortality (RR 0.81; 95% Confidence Interval (CI) 0.71–0.93; P < 0.05) and inflammatory response (levels of IL-6 and TNF-α at 24 h: SMD: -1.46; 95% CI -2.10, -0.83 , p＜0.05； SMD: -1.20; 95% CI -1.78, -0.62 , p＜0.05, respectively). Trial-sequential-analysis showed that it is not up to required information size but the cumulative Z curve crossed the trial sequential monitoring boundary for benefit. Using cumulative meta-analysis, a steady reduction in mortality was observed after 2020. Risks of total adverse events were similar between dexmedetomidine and the other sedatives (OR = 1.06, 95% CI 0.50, 2.25, p = 0.87), but dexmedetomidine increases the risk of arrhythmias (OR 2.36, 95% CI 1.15, 4.8; P = 0.02; I2 = 0%). ICU stays (SMD: −0.26; 95% CI −0.70,0.18, p = 0.24), duration of mechanical ventilation, incidence of delirium (RR 0.89; 95% CI 0.66 to 1.19, low certainty; P = 0.43)，the levels of alanine transaminase and creatinine changes at 24 h (Respectively: p = 0.17 and 0.30) were all not significantly reduced.ConclusionThe use of dexmedetomidine in comparison to other sedative agent reduces significantly the all-cause mortality and inflammatory response in patients with sepsis. Dexmedetomidine might lead to an increased incidence of arrhythmias, but its safety profile did not show significant differences in the incidence of the total adverse events.
QAAskeR+: A Novel Testing Method for Question Answering Software via Asking Recursive Questions
Authors: Xie Xiaoyuan , Jin Shuo , Chen Songqiang 
Published: April 2022

Abstract
Question Answering (QA) is an attractive and challenging area in NLP community. With the development of QA technique, plenty of QA software has been applied in daily human life to provide convenient access of information retrieval. To investigate the performance of QA software, many benchmark datasets have been constructed to provide various test cases. However, current QA software is mainly tested in a reference-based paradigm, in which the expected outputs (labels) of test cases are mandatory to be annotated with much human effort before testing. As a result, neither the just-in-time test during usage nor the extensible test on massive unlabeled real-life data is feasible, which keeps the current testing of QA software from being flexible and sufficient. In this work, we propose a novel testing method, QAAskeR+, with five new Metamorphic Relations for QA software. QAAskeR+ does not refer to the annotated labels of test cases. Instead, based on the idea that a correct answer should imply a piece of reliable knowledge that always conforms with any other correct answer, QAAskeR+ tests QA software by inspecting its behaviors on multiple recursively asked questions that are relevant to the same or some further enriched knowledge. Experimental results show that QAAskeR+ can reveal quite a few violations that indicate actual answering issues on various mainstream QA software without using any pre-annotated labels.
3D seismic response characteristics of a pile-mat-founded AP1000 nuclear-island building considering nonlinear hysteretic behavior of soil
Authors: Chen Guoxing , Zhu Shengdong , chen weiyun , Li Xiaojun , Juang Charng Hsein 
Published: April 2022

Abstract
Given the increase of nuclear power plants, it has become unavoidable for the pile-supported nuclear-island buildings to be constructed on the coastal deposits potentially influenced by strong earthquakes. The influences of the hysteresis nonlinearity of soil and the soil-pile-structure interaction (SPSI) have not yet been considered in the seismic response analysis of the nuclear-island building, although it is a vital issue. On the basis of a newly developed generalized non-Masing hysteretic constitutive model, a 3D integrated simulation method is proposed to evaluate the seismic responses of the pile-mat-founded nuclear-island building system subjected to multidirectional earthquake motions. This integrated method involves an explicit parallel algorithm framework, comprising the nuclear-island building modeling, the pile-mat foundation modeling, the inhomogeneous soil domain modeling, and the artificial boundary condition. The bedrock records of near-field, moderate-far field and far-field earthquake scenarios are assumed for determining the bedrock motions of the ultimate and operational safety earthquakes. For an actual pile-mat-founded AP1000 nuclear-island building, the simulation results show the complexity and significance of the coupling effect of the site, the tridirectional earthquake shaking, and the secondary nonlinearity of soil. Such a complex coupling effect significantly increases the seismic responses of the pile-mat-founded nuclear-island building. A notable finding is that the scenario of moderate-far field and far-field strong motions may have more destructive potential to the pile-mat-founded nuclear-island buildings than the scenario of near-field strong motions with the shorter durations and same amplitude. The results provide insights into the seismic design of the pile-mat-founded nuclear-island buildings, which could guide the design and construction of such similar facilities in the high seismic intensity regions.
Ethanol production from cellulosic materials of sugarcane scum by bio-fermentation and acid hydrolysis
Authors: Asadi Pouyan , baher elham , Vaezi Zahra , Tilami Salma Ehsani 
Published: April 2022

Abstract
Bioethanol is a promising candidate and the eco-friendly material for reducing greenhouse gases and it can be a good alternative to fossil fuels. We describe a development of framework for green fuel production. The production of bioethanol as a fuel has been investigated from sugarcane scum (bagasse, which can be hydrolyzed and fermented by high carbon content). In this process, carbohydrates were converted into monomers and then by fermentation of these monomers leads to the production of ethanol. Samples were prepared at different experimental conditions (Saccharomyces and acidic media for hydrolyzing) to carry out the fermentation process. Finally, identification and characterization of ethanol for the best condition was performed by GC-MS (500 gr bagasses, 0.25 gr yeast in acidic media and boiling temperature). The use of cheap yeast is a novelty of this work because it provides commercialization of bioethanol production which is very important in ethanol generation.