bluuebunny/crossref_metadata_2025_split huggingface dataset:
UPAYA MENINGKATKAN HASIL BELAJAR SISWA DALAM PEMBELAJARAN MATEMATIKA MATERI KESEBANGUNAN DAN KEKONGRUENAN MELALUI STRATEGI PEMBELAJARAN PROBLEM BASED LEARNING PADA SISWA KELAS IX C MTS NEGERI 5 DEMAK
Authors: Suprih Astuti 
Published: March 2022

Penelitian ini bertujuan dapat meningkatkan hasil belajar siswa dalam Pembelajaran Matematika Materi Kesebangunan dan kekongruenan Melalui Strategi pembelajaran Problem Based Learning pada siswa kelas IX C MTs Negeri 5 Demak. Metode penelitian dilakukan dengan metode Penelitian Tindakan Kelas. Berdasarkan hasil pembelajaran pada siklus I yang oleh peneliti diawali dengan perencaaan dilanjutkan dengan tindakan, observasi dan refleksi. Peneliti melalui model Problem Based Learning, ternyata hasil yang dicapai dalam pembelajaran matematika pada siklus I beberapa siswa masih terlihat kurang antusias dan kurang memahami materi yang di berikan. Adapun siklus II, siswa mengikuti kegiatan pembelajaran sangat antusias. Pemberian materi bangun datar sisi lengkung menggunakan Problem Based Learning melalui dua siklus, rata-rata nilai tes akhir pada siklus I sebesar 62,52 dan rata-rata nilai tes akhir pada siklus II sebesar 83,33. ini mengalami perubahan yang signifikan sehingga terjadi peningkatan hasil belajar siswaKata Kunci: hasil belajar, problem based learning, siswa SMP
PENGARUH SELF DETERMINATION DAN PRESTASI AKADEMIK TERHADAP KEMATANGAN KARIER SISWA MA NU NURUL HUDA
Authors: Fitri Hanina Yaumil , Saraswati Sinta 
Published: March 2022

Penelitian ini membahas mengenai pengaruh self determination dan prestasi akademik terhadap kematangan karier siswa di MA NU Nurul Huda Kota Semarang. Tujuan dari penelitian ini adalah untuk mengetahui adakah pengaruh antara self determination dan prestasi akademik terhadap kematangan karier siswa MA NU Nurul Huda Kota Semarang dengan sampel sebanyak 169 siswa. Penelitian ini menggunakan metode penelitian kuantitatif dengan jenis ex-post facto. Hasil analisis deskriptif menunjukkan bahwa siswa MA NU Nurul Huda Kota Semarang memiliki tingkat self determination sedang (M = 73,13), tingkat prestasi akademik tinggi (M = 80,85), dan tingkat kematangan karier sedang (M = 144,75). Hasil analisis regresi berganda untuk pengaruh self determination terhadap kematangan karier didapatkan hasil signifikan (β = 1,367; t = 10,660; Sig. = 0,000), pengaruh prestasi akademik terhadap kematangan karier tidak signifikan (β = -0,389; t = -0,837; Sig. = 0,404), dan pengaruh self determination dan prestasi akademik secara simultan terhadap kematangan karier signifikan (R = 0,638; R2 =0,407; F= 57,020; Sig. = 0,000). Berdasarkan hasil penelitian, diharapkan guru BK dapat memeberikan pelayanan Bimbingan dan Konseling baik secara individu atau kelompok untuk meningkatkan kematangan karier dan self determination siswa dan untuk mempertahankan tingkat prestasi akademik siswa.
PENGARUH RELIGIUSITAS DAN PENGGUNAAN MEDIA SOSIAL TERHADAP PERILAKU AGRESIF SISWA SD MUHAMMADIYAH KARANGWARU KOTA YOGYAKARTA
Authors: Lestariningsih Sri , Rahmatullah Azam Syukur , Purnomo Halim 
Published: March 2022

Penelitian ini bertujuan untuk menjelaskan gambaran religiusitas, penggunaan media sosial siswa kelas IV, V dan VI SD Muhammadiyah Karangwaru Kota Yogyakarta dan mengetahui pengaruh religusitas dan penggunaan media sosial dengan perilaku agresif siswa kelas IV, V dan VI SD Muhammadiyah Karangwaru Kota Yogyakarta. Teknik pengumpulan data yang digunakan adalah menggunakan angket dengan jumlah sampel sebanyak 142 siswa. Hasil penelitian menunjukkan perilaku religiusitas siswa memiliki kategori religiusitas yang baik dengan analisis deskripif pada rentang 68 – 84 % sedangkan penggunaan media sosial siswa berada pada tingkatan cukup baik pada rentang 43 – 68 %. Religiusitas siswa berpengaruh terhadap perilaku agresi berdasarkan hasil uji t dengan nilai signifikansi 0,01. Penggunaan media sosial tidak berpengaruh terhadap perilaku agresi karena memiliki nilai signifikansi 0,487. Hasil uji F, religiusitas dan penggunaan media sosial berpengaruh secara simultan terhadap perilaku agresi siswa sebesar 7,4%. dengan nilai signifikansi 0,05.
PENDIDIKAN KARAKTER PEDULI LINGKUNGAN DAN MENJAGA KEBERSIHAN DI SEKOLAH
Authors: Ismail M. Jen 
Published: March 2022

Karakter merupakan sesuatu yang ada pada tiap diri individu yang dibentuk dalam lingkungan keluarga sejak kecil. Namun, karakter juga ada pada tiap diri individu sejak lahir. Karakter yang baik dapat dibentuk melalui pendidikan, salah satunya melalui pendidikan karakter di sekolah. Untuk mewujudkannya dapat dilakukan dengan menanamkan nilai-nilai karakter terhadap peserta didik. Salah satu karakter yang harus dibentuk sejak usia dini yaitu karakter peduli lingkungan. Pembentukan karakter peduli lingkungan dapat dimulai dari lingkungan sekolah dengan menjaga kebersihan sekolah. Dengan terbiasanya siswa menjaga lingkungan sekolah, maka siswa akan peduli terhadap lingkungan di sekitarnya. Program yang biasa dilakukan disekolah terdapat unsur K3 (kebersihan, keindahan, kerapian), meliputi piket bersama di kelas dan lingkungan sekolah serta belajar merawat tumbuhan dan menjaganya. Dengan program ini bertujuan untuk memperkuat dan meningkatkan aktivitas kesadaran siswa di sekolah agar menjaga kebersihan lingkungan serta merawat tumbuhan di sekitarnya. Karena dengan bersihnya lingkungan sekolah, maka akan membuat siswa serta guru nyaman dalam melakukan kegiatan belajar mengajar
Comparison of respiratory tract pathogens and antibiotic susceptibility profiles of patients diagnosed with COVID-19 with pre-COVID-19
Authors: ŞENOL Feray Ferda , BAHÇECİ İlkay , ARSLAN Nuray , AYTAÇ Özlem , ÖNER Pinar , AŞCI TORAMAN Zülal 
Published: March 2022

Objective: It is aimed to compare the respiratory tract agents and antibiotic resistance rates in patients with a diagnosis of COVID-19 with the non-COVID-19 period.
Material and Method: Patients diagnosed with bacterial respiratory tract infection between March 2019 and March 2021 were included in the study. Bacteria identification and antibiotic susceptibility were evaluated according to automated system and EUCAST standards.
Results: Between March 2019-March 2020 (before the pandemic), the most common bacterium was Pseudomonas aeruginosa (P. aeruginosa) 280 (15.5%) second Acinetobacter baumannii (A. baumannii) in a total of 1797 patients hospitalized in the service and intensive care units, and the resistance rates were the same. Between March 2020 and 2021, a total of 1357 COVID -19 patients were found in clinical and intensive care units, and the most common reproducing agent was A. baumannii 168 (12.3%), the second P. aeruginosa 164, and resistance rates were found to invrease.
Conclusion: The increase in the resistance rates of bacteria causing respiratory tract infection was remarkable. It was determined that P. aeruginosa and A. baumannii, which were the most common isolates before the pandemic and showed high resistance rates against all antibiotic groups, were the most common bacteria during the pandemic period.
STUDY OF PATHOGENESIS, DIAGNOSIS AND VARIOUS TREATMENT APPROACHES FOR DIARRHOEA IN INFANTS
Authors: Agarwal Puneesh 
Published: March 2022

Diarrhea is common in infants (children less than 2 years of age), usually acute, and, if chronic, commonly caused by allergies and occasionally by infectious agents. Congenital diarrheas and enteropathies (CODEs) are rare causes of devastating chronic diarrhea in infants. Evaluation of CODEs is a lengthy process and infrequently leads to a clear diagnosis. However, genomic analyses and the development of model systems have increased our understanding of CODE pathogenesis.
The European Society for Paediatric Gastroenterology, Hepatology and Nutrition and the European Society of Paediatric Infectious Diseases guide­lines make a stronger recommendation for the use of probiotics for the management of acute gastroenteritis, particularly those with documented efficacy such as Lactobacillus rhamnosus GG, Lactobacillus reuteri, and Saccharomyces boulardii.
Studies of microbial pathogens and the toxins they produce are important for determining the mechanisms by which they cause disease and spread throughout a population. Some bacteria produce secretory enterotoxins (such as cholera toxin or the heat-labile or stable enterotoxins produced by Escherichia coli) that invade cells directly. Others invade cells or produce cytotoxins (such as those produced by Shigella, enteroinvasive E coli, or Clostridium difficile) that damage cells or trigger host responses that cause small or large bowel diseases (such as enteroaggregative or enteropathogenic E coli or Salmonella). Viruses (such as noroviruses and rotaviruses) and protozoa (such as Cryptosporidium, Giardia, or Entamoeba histolytica) disrupt cell functions and cause short- or longterm disease.
KEYWORDS: Diagnosis & Treatment, Diarrhoea, Acute infective gastroenteritis, Oral rehydration solution, Vomiting
Return Portofolio Optimal Menggunakan Single View Black-litterman Model dengan Pendekatan ARIMA (Autoregressive Integrated Moving Average)
Authors: Arisena Adri 
Published: March 2022

At this time stock investment is one investment option. To obtain optimal profits a stock portfolio is needed.
A portfolio is a combination of several shares. To form a portfolio, a model is needed to achieve an optimal portfolio. This research uses Single View Black-Litterman Model with ARIMA (Autoregressive Integrated Moving Average) approach. The selected shares are PT. Jasa Marga (JSMR), PT. Unilever Indonesia (UNVR), and PT. Waskita Karya (WSKT).
Analisis Faktor-faktor Penyusutan Susu Sapi Untuk Meminimalkan Kerugian (Studi Kasus pada Koperasi Unit Desa Mandiri Bayongbong, Kabupaten Garut)
Authors: Sudewa Jaka 
Published: March 2022

The existence of depreciation of cow's milk makes the cooperative must bear the costs of depreciation, because every depreciation of milk has become a purchase cost. Depreciation of cow's milk affects the business results achieved by the Mandiri Bayongbong KUD dairy business unit, the amount of depreciation reduces the volume of milk sales to IPS and the amount of business results generated by the dairy business unit. Depreciation can be overcome by carrying out quality control as an appropriate control mechanism towards improving quality.
The method used in this research is the case study method, which is one of the descriptive research methods. Where used direct observation techniques (observation) of the object under study with the use of cause and effect diagrams, why analysis tables and pareto diagrams as research analysis aids. The sampling technique uses the strata method based on the ownership of cattle on a business scale with the number of productive female livestock. Then obtained the following sample values: n1 = 9 people, n2 = 9 and n3 = 17 people.
The results showed that the amount of shrinkage of cow's milk was 3,736 liters or 0.77% due to poor quality milk, broken or damaged, left in a shelter or spilled / scattered when depositing milk in the TPK or IPS. After using the Pareto diagram, the factors that cause the most influential problems are the materials, equipment, methods, and enclosures.
OVERVIEW OF JURIDICAL LEGAL POSITION OF CHILDREN FROM MARRIAGE SERIES ACCORDING TO ARTICLE 43 ACT NO. 1 YEAR 1974 ABOUT MARRIAGE
Authors: Karim Andi Yuliana , Hafidz Ma’ruf , Bima Muh. Rinaldy 
Published: March 2022

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Mindfulness and meditation - Training our spidey-senses for critical qualitative health research
Authors: Gardner Paula (Pauli) 
Published: March 2022

I’ve been training students in mindfulness and meditation for over 10 years. What began as a pedagogical survival tool (for my own mental health) soon emerged as something that was incredibly beneficial to my public health students. Turns out sitting in silence, anchoring ourselves in the present moment, and not doing but instead being, is not only good for your physical, social, and emotional health, it’s a great tool for learning. Students report that closing their eyes and sitting together in meditation fosters trust and compassion and builds a sense of community. These feelings allow them to take risks in their learning, to deeply engage with the material, and to participate openly and creatively in ways that foster real growth.
During the pandemic I’ve had time to reflect on what I have observed is another benefit of mindfulness and meditation training – that these practices help students develop important skills – or spidey-senses – that are the superpowers of critical qualitative health researchers. These include the ability to be fully present in our work, to listen deeply, to be curious and non-judgemental, to not be attached to outcomes and what we expect to hear or learn, to come to each study and each participant with ‘beginners mind’, to prioritize different ways of knowing, and to accept when things don’t go according to plan (as they always seem to do in qualitative research).
In this presentation I welcome all superhero’s and in particular those interested in developing their own and their students spidey-senses. In our time together I’ll share some of the science on why this practice makes good scientists, demonstrate a practice, and provide some tips for those interested in trying it in their own classrooms.
During the pandemic I’ve had time to reflect on what I have observed is another benefit of mindfulness and meditation training – that these practices help students develop really important skills – or spidey-senses – that are the superpowers of critical qualitative health researchers. These include the ability to be fully present in our work, to listen deeply, to be curious and non-judgemental, to not be attached to outcomes and what we expect to hear or learn, to come to each study and each participant with ‘beginners mind’, to prioritize different ways of knowing, and to accept when things don’t go according to plan (as they always seem to do in qualitative research).
In this presentation I welcome all superhero’s and in particular those interested in developing their own and their students spidey senses. In our time together I’ll share some of the science on why this practice makes good scientists, demonstrate a practice, and provide some tips for those interested in trying it in their own classrooms.
Intralymphatic Immunotherapy (ILIT) With Bee Venom Allergens: A Clinical Proof-of-Concept Study and the Very First ILIT in Humans
Authors: Chabot Alexandra , Senti Gabriela , Erdmann Iris , Prinz Bettina M. , Wüthrich Brunello , Šošić Lara , Kündig Thomas M. , Johansen Pål 
Published: March 2022

BackgroundSubcutaneous venom immunotherapy (VIT) represents an effective treatment against bee venom allergy. However, it involves long treatment times, high costs, and the risk of adverse events (AEs). Shorter, safer, and cheaper treatment options are therefore pursued.ObjectiveTo determine the safety, immunogenicity, and efficacy of bee venom intralymphatic immunotherapy (ILIT).MethodsIn an open pilot study, 12 patients received bee venom ILIT in three sessions with 14-day intervals: 0.1–5 μg/dose. Ultrasound imaging was applied to guide an injection and to document the lymph node structure. In a second study, 67 patients from 15 centers in Europe and Australia were randomized to receive four doses of either 10- or 20-μg bee venom ILIT with 28-day intervals. Clinical endpoints included specific IgE and IgG and protection after a bee sting challenge. These studies were performed in the years 2000–2003.ResultsIn a proof-of-concept study, no serious AEs were observed. An increase in allergen-specific IgG1 but no IgG4 and IgE was observed. ILIT induced the protection against a bee sting challenge in 7 out of 8 challenged patients. In a multicenter study, an increase in allergen-specific IgG and IgE was observed, with the highest increase in patients receiving a higher ILIT dose. The study was terminated due to several serious AEs upon the sting challenge provocation after the completion of treatment. However, out of 45 patients challenged, 15 (65%) and 18 (82%) patients in the 10- and 20-μg group, respectively, showed an improvement of two grades or more. No correlation was observed between antibody levels and sting protection.ConclusionsWhile a pilot study suggested the safety and efficacy of bee venom ILIT, a high number of AEs seen after the sting challenge following a randomized study indicate that the immunology protection offered by bee venom ILIT is insufficient. Of note, the bee venom allergen extract used in the two studies were from the two different providers. While the first study used a formulation approved for use in subcutaneous VIT, the second study used a nonapproved formulation never tested in humans. Further studies on approved formulations should be performed to generate conclusive results regarding the safety and efficacy of bee venom ILIT.
Toward Understanding the Alginate Catabolism in Microbulbifer sp. ALW1 by Proteomics Profiling
Authors: Li Zhipeng , Huang Xiaoyi , Guo Yuxi , Zhang Chenghao , Yang Liang , Du Xiping , Ni Hui , Wang Xuchu , Zhu Yanbing 
Published: March 2022

The bacterial strain of Microbulbifer sp. ALW1 has demonstrated visible ability of degrading the cell wall of Laminaria japonica, and biochemical characterization has been performed on some individual enzymes to elucidate its genetic basis. However, it still remains elusive how strain ALW1 successfully breaks down the major cell wall component alginate polysaccharide and colonizes on its marine host. In this study, a mass spectrometry-based quantitative analysis of the extracellular and intracellular proteomes was introduced to elucidate the alginate degradation pathway in ALW1 strain. Mass spectrometry and biochemical assays indicated that strain ALW1 could effectively degrade alginate polysaccharide into disaccharides and trisaccharides within 12 h. Proteome analysis identified 156 and 1,047 proteins exclusively localized in extracellular and intracellular compartments, respectively, with 1,086 protein identities of dual localization. Functional annotation of the identified proteins suggested the involvement of diverse catalytic enzymes and non-catalytic molecules for the cleavage and metabolism of alginate polysaccharide. A simplified pathway was constructed to demonstrate the extracellular digestion, active transport, and intracellular conversion of alginate polysaccharide and its fragmented oligosaccharides, casting a picture of genetic loci controlling alginate catabolism by ALW1 strain. This study aims to provide a guide for utilization and genetic manipulation of the bacterial strain ALW1 for efficient alginate oligosaccharides production by fermentation.
In Vitro Comparison of Different Invisalign® and 3Shape® Attachment Shapes to Control Premolar Rotation
Authors: Ferlias Nikolaos , Dalstra Michel , Cornelis Marie A. , Cattaneo Paolo M. 
Published: March 2022

Aim: To evaluate in vitro the differences of various Invisalign® attachments in their effectiveness during derotation of an upper second premolar in terms of forces and moments created and compare them to the 3Shape® box attachment as well as to no attachment at all.Materials and Methods: A Force System Identification (FSI) machine, comprising two load sensors, was used in this study. Sensor 1 was connected to the test tooth (i.e. upper second premolar) carrying a different attachment design, and the fixed sensor (Sensor 2) was connected to the base model. Once the corresponding aligner was passively seated on the teeth, 12 different setups (i.e. 11 different attachments and one setup with no attachment at all) were tested by rotating the test tooth 4.5° mesially and 4.5° distally, in increments of 0.45°.Results: The vertical rectangular attachments were able to generate the highest derotational moment on both mesial and distal rotations but also received the most side effects (intrusive force, torque, and tipping). The no-attachment setup performed least favorably in terms of derotational ability but exhibited the least side effects. In the y-axis, all attachments received a buccal root torque with a lingual force during disto-rotation and a lingual root torque with a buccal force during mesio-rotation.Conclusion: Attachments are necessary for derotating an upper second premolar. An aligner incremental change of more than 1° derotation can generate high moments. The vertical rectangular attachments perform best in derotations; however, they exhibit the most side effects. Finally, despite presenting the least side effects, derotation of a premolar with no attachment is not as efficient.
Molecular Characterization Clinical and Immunotherapeutic Characteristics of m5C Regulator NOP2 Across 33 Cancer Types
Authors: Liu Taisheng , Zhang Jian , Lin Chunxuan , Liu Guihong , Xie Guofeng , Dai Zili , Yu Peng , Wang Jian , Guo Liyi 
Published: March 2022

Background: Recent studies have identified that RNA 5-methylcytosine (m5C) is a wide-spread epigenetic modification in tumorigenesis. However, the clinical and immunotherapeutic values of m5C regulator NOP2 in 33 cancers remain unclear.Methods: The mRNA expression data and clinical data of 33 cancers were downloaded from The Cancer Genome Atlas (TCGA) database. The immunotherapy data including GSE67501, GSE78220, GSE35640, and IMvigor210 were downloaded from the Gene Expression Omnibus (GEO) database and the website based on the Creative Commons 3.0 license (http://research-pub.Gene.com/imvigor210corebiologies). The expression, survival, clinical parameters, tumor mutation burden (TMB), microsatellite instability (MSI), and tumor microenvironment (TME) were evaluated. Finally, the relationship between NOP2 and immunotherapy response was further explored.Results: NOP2 was significantly upregulated in most cancers, and high NOP2 expression was associated with poor prognosis. TMB, MSI, and NOP2 activities were involved in the dysregulation of NOP2. NOP2 was closely associated with immune cell infiltration, immune modulators, and immunotherapeutic inactivation.Conclusions: We comprehensively explored the clinical and immunotherapeutic values of NOP2 in cancers, providing evidence regarding the function of NOP2 and its role in clinical treatment.
Regional Myocardial Work Measured by Echocardiography for the Detection of Myocardial Ischemic Segments: A Comparative Study With Invasive Fractional Flow Reserve
Authors: Guo Ying , Yang Chenguang , Wang Xiang , Pei Zuowei , Zhu Huolan , Meng Xuyang , Zhou Ziyu , Lang Xiaotong , Ning Sun , Zhang Ruisheng , Wang Fang 
Published: March 2022

PurposeThis study is to assess the diagnostic value of noninvasive regional myocardial work (MW) by echocardiography for detecting the functional status of coronary stenosis using fractional flow reserve (FFR) as a standard criterion.MethodsA total of 84 consecutive patients were included in this study, among which 92 vessels were identified with ≥50% stenosis confirmed by invasive coronary angiography. Patients were investigated by invasive FFR and transthoracic echocardiography. Regional MW indices including myocardial work index (MWI), myocardial constructive work (MCW), myocardial wasted work, and myocardial work efficiency were calculated.ResultsMWI and MCW were significantly impaired in the FFR ≤ 0.75 group compared with the FFR &gt; 0.75 group (both p &lt; 0.01). There were significant positive associations between MWI and MCW with FFR. In total group, MWI &lt;1,623.7 mmHg% [sensitivity, 78.4%; specificity, 72.2%; area under the curve value, 0.768 (0.653–0.883)] and MCW &lt;1,962.4 mmHg% [77.0%; 72.2%; 0.767 (0.661–0.872)], and in single-vessel subgroup, MWI &lt;1,412.1 mmHg% [93.5%; 63.6%; 0.808 (0.652–0.965)] and MCW &lt;1,943.3 mmHg% [(84.8%; 72.7%; 0.800 (0.657–0.943)] were optimal to detect left ventricular segments with an FFR ≤ 0.75. MWI and MCW significantly increased after percutaneous coronary intervention in 13 cases.ConclusionIn patients with coronary artery disease, especially those with single-vessel stenosis, the regional MW measured by echocardiography exhibited a good diagnostic value in detecting significant myocardial ischemia compared to the standard FFR approach.