bluuebunny/crossref_metadata_2025_split huggingface dataset:
POTENSI PROBIOTIK SEBAGAI REGULATOR SITOKIN INFLAMASI DALAM PERBAIKAN KLINIS PASIEN COVID-19
Authors: SUCIANGTO WILLIAM , Zainal Ahmad Taufik Fadillah , Nasrum Nada Indira Ramadhani 
Published: April 2022

ABSTRAK
Coronavirus disease 2019 (COVID-19) merupakan sebuah pandemic global yang diakibatkan oleh severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Penelitian-penelitian terbaru menunjukkan bahwa fenomena badai sitokin, replikasi virus yang tinggi, dan terhambatnya persinyalan Interferon type 1 (IFN-I) berkontribusi terhadap keparahan klinis COVID-19. Progresivitas respon IFN-I yang lambat mengakibatkan peningkatan akumulasi monosit patogenik sehingga terjadi imunopatologi paru, kebocoran vaskular, dan respon sel T suboptimal. Selain itu, berbagai studi lainnya juga melaporkan bahwa pemberian probiotik dapat memediasi respon antivirus terhadap coronavirus yang menyerang manusia. Dalam studi literatur ini kami mendiskusikan potensi probiotik dalam meregulasi badai sitokin dan produksi Interferon tipe 1 yang dapat memperbaiki gejala klinis pada pasien-pasien COVID-19. Studi ini dibuat berdasarkan hasil sintesis kualitatif beberapa literatur valid. Hasil review ini menunjukkan bahwa beberapa jenis probiotik mampu menekan produksi sitokin pro-inflammatori yang terlibat dalam fenomena sitokin dan merangsang produksi IFN tipe 1. Melalui mekanisme pencegahan terjadinya badai sitokin dan meningkatkan produksi IFN tipe 1, probiotik memiliki potensi sebagai regulator sistem imun yang dapat meningkatkan luaran klinis pada pasien-pasien COVID-19. Namun demikian, penelitian dengan skala lebih besar dan lebih lanjut masih diperlukan untuk membuktikan bahwa probiotik mampu menjadi solusi dalam tatalaksana infeksi-infeksi akibat virus.
Potensi Ekstrak Moringa Oleifera Untuk Mengatasi Gastroenteritis Bakteri
Authors: Kusbijantoro Yemima Billyana , Naufizdihar Nabila Atika , Adji Arga Setyo 
Published: April 2022

ABSTRAK

Gastroenteritis bakteri adalah salah satu penyakit di daerah tropis berupa peradangan lambung dan usus akibat beberapa bakteri, seperti Salmonella, Campylobacter, Shigella, E. coli, Vibrio, Yersinia, dan Listeria dengan gejala diare tanpa maupun disertai muntah, dan sering demam. Gastroenteritis menjadi penyakit global dengan prevalensi tertinggi pada komunitas agrikultur terutama petani dan nelayan. Penelitian ini bertujuan untuk mengetahui potensi ekstrak daun dan biji Moringa oleifera sebagai alternatif terapi gastroenteritis bakteri. Metode penulisan jurnal menggunakan pendekatan tinjauan pustaka yang berasal dari analisis dan sintesis berbagai referensi terkait. Penulis memilih jurnal full text dan buku tahun terbit maksimal sepuluh tahun terakhir melalui beberapa database, yaitu PubMed, Google Scholar, Science Direct, dan Cochrane dengan kata kunci: diare, gastroenteritis, dan Moringa oleifera. Ekstrak biji dan daun Moringa oleifera berperan dalam mencegah beberapa efek dari patogenesis diare akibat infeksi bakteri. Metanol, N-hexane, etil asetat, flavonoid, fenol, saponin, alkaloid, tanin, dan steroid dari ekstrak biji dan daun Moringa oleifera memiliki efek antibakteri. Kandungan quercetin memiliki efek antiinflamasi. Kandungan tanin, flavonoid, dan alkaloid memiliki aktivitas antidiare. Kandungan etanol dan tanin memiliki efek antiulkus. Potensi tersebut dapat membantu penyembuhan penderita gastroenteritis bakteri.
DISSECTING FASXIATOR POTENTIAL AS ALTERNATIVE ANTICOAGULANT BY PREVENTING THROMBOSIS THROUGH INHIBITION OF CONTACT ACTIVATION SYSTEM
Authors: Aurelie Nadine 
Published: April 2022

Thrombosis, an imbalanced interaction between blood components, contributes greatly to deaths that occur worldwide. Therefore, treatment that can reverse the condition of blood clotting and hypercoagulability is essential. However, the drugs used to treat thrombosis-based diseases have side effects that can be seen in short and long term, particularly an increased risk of bleeding. Therefore, an alternative treatment is needed to overcome the problem of thrombosis without causing significant side effects that can endanger the lives of anticoagulant drug users. The solution to this problem is none other than nature provided, a protease inhibitor obtained through the venom of the Bungarus fasciatus snake, Fasxiator.
Fasxiator can dilute blood through the inhibition of Contact Activation System (CAS) mechanism, specifically inhibiting factor XIa. The advantage of blood clotting inhibition through the CAS method is that it does not affect normal hemostasis, thereby minimizing the bleeding problems that are common with other anticoagulant drugs. Animal studies in rats demonstrated properties of high target selectivity for factor XIa, effectiveness, and high safety profile of Fasxiator, enabling the application of Fasxiator as an anticoagulant in the future.
Therefore, based on the discussion that has been explained above, Fasxiator has the potential to be used as an anticoagulant on humans in the future due to its high selectivity, effectivity, and safety in previous animal studies.
INTEGRASI ANALISIS UJI CETAK NAPAS BERBASIS E-NOSE SEBAGAI SOLUSI BARU DETEKSI DINI PENYAKIT PARU OBSTRUKTIF KRONIK AKIBAT POLUSI UDARA DI LINGKUNGAN RUMAH PADA MASA PANDEMI COVID-19
Authors: Kalaij Ayers Gilberth Ivano 
Published: April 2022

Background: Although 64 million people has suffered from COPD, studies have shown that 70% of COPD patients worldwide was underdiagnosed due to many reasons. Adequate and fast detection are crucial in determining prognosis of this disease. However, many lungs function test still have disadvantages and limitations. Covid-19 pandemic era has limited our mobility and increase the risk of household air-pollution exposure which increase the risk of COPD. Thus, alternative solutions are needed to detect and screened household air pollution related COPD patients as fast as possible.
Discussion: E-nose technology has been proven to effectively detects various respiratory diseases. This could be the alternative solution to provide COPD diagnostic tests which usually use spirometry with its disadvantages. Breath-print based VOC detection could be sensor biomarker for respiratory diseases, even COPD. If this is integrated with primary care systems in Indonesia during Covid-19 pandemic era, it could be the solution in early detection of COPD.
Conclusion: Integration of e-nose based breath-print test is potential to be the solution of early and accurate detection of COPD which are non-invasive and patient-well with its advantages.
TOCILIZUMAB AS MONOCLONAL ANTIBODY THERAPY IN OVERCOMING ACUTE RESPIRATORY DISTRESS SYNDROME IN COVID-19 PATIENTS
Authors: Satyagraha Muhammad Thifan , Sheridan Graceanne , Laryan Vito Etenio Ade , Hidayatullah Gibran Chandra Syarif 
Published: April 2022

Acute respiratory distress syndrome (ARDS) as a clinical manifestation of severe pneumonia is a major cause of death for patients with coronavirus disease 2019 (COVID-19) who are treated in intensive care units (ICU). ARDS is triggered by cytokine storm. Cytokine storm is characterized by an increased in proinflammatory cytokines such as IL-6, IL-1α, and IL-1β. Thus, IL-6 and IL-1 cytokine inhibitors in the form of monoclonal antibodies are needed to overcome this. This review of the scientific literature aims to identify the effect of monoclonal antibody therapy, which is focusing on the inhibitors of cytokines IL-6 (tocilizumab) and IL-1 (anakira) in patients with severe pneumonia caused by severe acute respiratory coronavirus-2 (SARS-CoV-2) ) with clinical manifestations in the form of ARDS. The design used in the form of scientific literature review. Articles were collected via Google Scholar search engine through several data sources (Pubmed, Sciencedirect, Nature, Proquest, and Springer Link). Inclusion criteria used were literature sources published between 2011 – 2020 in the form of research articles, systematic reviews, annual reports, and/or books. Meanwhile, the exclusion criterion used was literature sources under 2011. Based on article search results, tocilizumab can efficiently improve clinical status and reduce the mortality rate of COVID-19 patients with ARDS. Even so, tocilizumab can increase the risk of infection and the evidence obtained by the authors was not enough to support the administration of tocilizumab outside of clinical trials. Thus, the safety and side effects of monoclonal antibodies need to be further investigated.
The Potential Increase of Household Consumption Through Online Shopping as East Java Economic Growth Acceleration Effort in The Covid-19 Pandemic: Optimization of Social Demographic and Spatial Factors
Authors: Purwa Taly , Krismaningtyas Yusi 
Published: April 2022

The economic shock as a result of the Covid-19 pandemic resulted in an economic contraction, including East Java. The shift in consumer behavior in utilizing e-commerce to adapt to pandemic constraints is a good catalyst for stimulating household final consumption as the largest shareholder in the East Java economy. This study tries to identify socio-demo graphic and spatial factors that can be optimized for the acceleration of East Java’s eco nomic growth during the disruption from the demand side. The results of the identification of individual behavior in online shopping as well as district/city aggregates indicate several socio-demographic and spatial factors that can be optimized. Mapping districts/cities based on the dimensions of online shopping activities and ICT infrastructure conditions can be a more specific alternative solution to further optimize the potential for increasing household consumption as an effort to accelerate economic growth during the Covid-19 pandemic appropriate with the characteristics of each region.
Organic farm products and socio demography
Authors: Siva E. , Chandrachud S. 
Published: April 2022

The literature highlights the growing consumers wish to purchase products produced organic. They believe that it is healthy and concerned about their environment. This way of consumers, which leads to willingness in purchase decision on products produced organic. The present study focuses on examining the relationship among various demographic factors and consumer willingness to buy Organic farm Products. To collect a primary data from respondent’s survey method is used. The study consists of 100 samples a non-probability convenience sampling technique is used. Further, one way-ANOVA were used to predict the relationship among demographic factors and consumer willingness to buy Organic farm Products. For statistical analysis, version 20 of SPSS is used. The study found that gender and consumer willingness to buy Organic farm Products, age and consumer willingness to buy Organic farm Products, educational qualification and consumer willingness to buy Organic farm Products and employment status and consumer willingness to buy Organic farm Products have a significant relationships. However the study test other demographic character marital status, this characters don’t have a relationship with willingness to buy Organic farm Products.
Kap survey on stainless steel crowns among undergraduates
Authors: Ranjana V , Deepak S , Sandeep Adimulapu Hima 
Published: April 2022

Introduction: Stainless steel crowns (SSC) are an important restorative armamentarium in paediatric dentistry. They are cemented with a biocompatible luting agent and are adapted to individual teeth. An appropriate cementing agent for SSCs is conventional glass ionomer cement. For the restoration of primary teeth, these crowns offer an outstanding alternative to other restorative materials. Aim: The main aim of this survey is to analyse the knowledge, attitude and practice on stainless steel crowns among undergraduates. Materials and method: Self-administrated questionnaire was designed based on the knowledge, attitude and practice of stainless steel crowns. The questionnaire contained 14 questions which were shared through Google forms link. The study population included undergraduates belonging to the 18 – 25 age group. The statistics done using SPSS software, chi square test was done to check the association and a p value of 0.05 was said to be statistically significant. The survey has been completed in the month of February 2021. Results: 53% think extensively decayed teeth are the major indication for stainless steel crown, 34% think as a preventive restoration and 13% think severe cases of bruxism.
Study of indications, techniques and results of operations on the sympathetic nervous system
Authors: Varshney G. P. , Varshney Sabhya , Varshney Ankit Raj , Varshney Amit , Dayal Anima 
Published: April 2022

Pain is an unpleasant sensation related to a noxious stimulus and accompanied by emotional and physiological reactions. Many factors affect these responses and the level of pain perceived from a given stimulus varies, both between subjects and within the same subject on different occasions. It is often assumed that all pain is similar but an individual's sensitivity to different types of experimentally induced pain is variable. This work was carried out on selected group of patients in Department of Surgery, underwent lumbar sympathectomy, cervical sympathectomy and celiac ganglion block were admitted during three years includes 55 cases i.e. 34 cases of lumbar sympathectomy 2 cases of splanchnicectomy, 3 cases of cervical sympathectomy and 16 cases of coeliac ganglion block. All the patients studied were smoker except the patients who were women and underwent sympathectomy.The most common presenting symptoms was pain in the lower limbs. Most often it was associated with ulcer or frank gangrene. Wasting of the foot and leg muscles was seen in quite a considerable number of the patients about 37%.Pain was relieved in approximately 88% patients underwent sympathectomy.
Formulation and evaluation of gastro retentive drug delivery system of candesartan cilexetil
Authors: Vantimita Sarovar Reddy , Jeganath S. 
Published: April 2022

It had became a challenging experience and effort for a formulator to develop and innovate a drug with maximum bioavailability. In the present study the focus of research is in the treatment of Hypertension, which is one of the most prevalent cardiovascular diseases in the world, affecting a big proportion of the adult and old age population. Candesartan Cilexetil angiotensin II to AT1 in many tissues including vascular smooth muscle and the adrenal glands, used for the treatment of high blood pressure. The drug has poor bioavailability due to limited oral absorption and maximum absorption at proximal intestine. This warrants and offers the use of Gastro Retentive Drug Delivery System (GRDDS) for sustained release formulation in order to achieve prolonged action and to improve patients compliance. Wet granulation technique was selected for preparation of tablets and the drug is formulated with HPMC K100M, ethylcellulose, sodium bicarbonate, Micro crystalline cellulose, Gelucire, talc and Aerosil etc. For around twelve formulations were made and evaluated for General appearance, Thickness, Hardness or Crushing strength Test, Friability Test, Estimation of drug content, In-vitro buoyancy studies and In-vitro drug release and the results obtained for the performed tests were found with in the range specified limits.
effect of betel leaves decoction on the healing of perineum wounds in postpartum mothers at the maternity health center in Demak District, Demak Regency
Authors: Wulandari Priharyanti , Kustriyani Menik 
Published: April 2022

Background : Perineal wound is a wound in perineal area naturally caused by episitomy. Injury to the perineum during childbirth causes the need for a proper treatment so that the injured can recover soon. The purpose of this study was to determine the effect of betel leaf decoction on the healing of perineal wounds in postpartum mothers. Methods : This study was carried out using Quasi Experimental research and post test with control group design of the intervention group and the control group. Meanwhile, the sampling technique used was the consecutive sampling method using the mann whitney test. Result : The intervention group which used betel leaf at fast category was 9 people (60.0%), medium category was 5 people (33.3%) and slow category was 1 person (6.7%). Meanwhile, the control group did not use betel leaf at the slow category was 10 people (66.7%), while those who were at the medium category was 5 people (33,3%). Conclution : The results showed that p value obtained was 000 (< 0.05), thus Ho is rejected and Ha is accepted, indicating that there was an effect of betel leaf decoction on the healing of perineal wounds in postpartum mothers.
Relationship of maternal parity with pre-eclampsia
Authors: Rangkuti Winnellia Fridina Sandy , Zaini Sarliana 
Published: April 2022

Background : Maternal mortality is an important indicator to assess the level of welfare of a country and the health status of women. The direct causes of maternal death were bleeding 28%, eclampsia 24%, infection 11%, puerperal complications 8%, and prolonged labor 5%. Pre-eclampsia is one of the causes of maternal death. One of the risk factors for pre-eclampsia is parity. The incidence of pre-eclampsia in Singkawang city Hospital was 82 cases out of 1,591 deliveries. Research Objectives : To determine the relationship between maternal parity and the incidence of pre-eclampsia in Singkawang City Hospital Research Design : Using analytical observational method with case control. The population in this study were all mothers who gave birth at the Singkawang City Hospital as many as 1,591 people, of which 82 of these cases had pre-eclampsia. The control sample was taken using a systematic sampling technique. Data were analyzed by univariate analysis and bivariate analysis. Results : based on a study conducted on 60 respondents, 30 people (50%) had pre-eclampsia, and 30 people (50%) did not experience pre-eclampsia, 36 people (60%) were at risk parity. Bivariate analysis showed that P value = 0.018 with 95% CI and 0.05.
effect of spiritual care training on nurses' perceptions of spirituality and spiritual care
Authors: Yanti Ni Putu Emy Darma , Suarningsih Ni Kadek Ayu 
Published: April 2022

Spirituality and spiritual care are essential components of health in meeting patient needs holistically. The fulfillment of spiritual needs can be a source of support and strength for patients to face their illnesses. Positive spirituality will have an impact on improving health, disease prevention, and patients’ quality of life. This study aimed to determine the effect of spiritual care training on nurses’ perceptions of spirituality and spiritual care. This was a pre-experimental study without a control group conducted on 124 nurses who were working at Udayana University Hospital. The study data were collected using the Spirituality and Spiritual Care Rating Scale Questionnaire (SSCRS). The training was conducted through lecture and group discussion with a duration of 120 minutes for each session. The data were analyzed using the Wilcoxon test with a 95% confidence level (a=0.05). The results showed that there was a significant difference in the perception scores of nurses' spiritual care before and after the training (p=0.006). This illustrates that spiritual care training is effective in increasing the perception of spirituality and spiritual care of nurses in providing health care for patients.
survey on dental students anxiety levels on performing extraction procedure
Authors: Guntupalli Yoshita , Deepak S , Sandeep Adimulapu Hima 
Published: April 2022

Introduction: Stress and anxiety go hand in hand and are common in the lives of every student these days. Dentistry being a professional course is very demanding and aims at bringing out the best in a student in clinical practice. Extraction is a very common but much feared procedure by both patients as well as dentists, especially those who are new to clinics. In our study we aim to find the anxiety levels in dental students towards the procedure of extraction. Materials and Methods: A self prepared questionnaire was circulated to 100 dental students and the responses were collected and statistically analysed. The statistical software used was SPSS version 23. The results were graphed for easy visualisation. Results and Discussion: It was found that females had higher anxiety levels towards extraction than males. Also BDS students had the highest anxiety levels followed by MDS students. PhD students were not found to have much anxiety towards extraction. Conclusion: In this study, anxiety levels towards extraction were found to be high among dental students. As the students gain experience, anxiety levels also decrease. Newcomers to the clinic face the highest anxiety levels.
Paraquat poisoning, what we should know
Authors: Manju B. , Jamal Sarfaraz , Lokesh N. K. 
Published: April 2022

Paraquat (PQ) a brown syrupy liquid also known as methyl viologen is a commonly used herbicide in India. A highly toxic compound to humans, although, a large majority of fatalities from PQ poisoning are suicides. Accidental exposure is causing immense harm to farmers and agriculture workers, which is not documented. Accidental or deliberate ingestion has an extremely high case-fatality rate, and clinical features are due to generating reactive oxygen species which cause cellular damage ultimately leading to multiorgan failure. At present there is no antidote to PQ poisoning, various treatment modalities from immunosuppressants to antioxidants are used with no clear clinical efficacy. Elimination methods such as haemodialysis and haemoperfusion when done early have shown to be useful in few studies. Recently drug-like Edaravone and Perfenidone are being used but with no survival benefit. Neither proper information nor training on the use of PQ and personal protective equipment are provided by agriculture offices to farmers leading to accidental exposure. Hence paraquat use has been restricted in many parts of the world and an appeal for a ban in India is underway as a need for preventive measures.
Neurological complications in COVID 19
Authors: Bakre Anand , Wanjari Anil , Aradhey Parag Rameshrao 
Published: April 2022

Long term effects of COVID-19 are not known and more studiesare needed to understand effects of COVID-19 on the brain, which have already been observed. An investigation on the incidence and relative risk of neurological and mental disorders after a COVID-19 diagnosis was part of this research. We used data from the electronic well-being records network in this review partner investigation. On or after June1st, 2021, members of all partners experienced a list occasion and were still living on December 31st, 2021, disregarding maturation, at the end of the year. All patients who had a confirmed finding of COVID-19 were allocated in this study. Patients with flu and those with any respiratory illness, including flu, were included in the second group of controls. The neurological symptoms were accessed and quantified according to the two groups and then statistically analysed for the significance. It was calculated that 82% of the 200 people identified with COVID-19 got a neurological or psychiatric diagnosis during the next six months.