bluuebunny/crossref_metadata_2025_split huggingface dataset:
Celastrol Loaded PEGylated Nanographene Oxide for Highly Efficient Synergistic
Chemo/Photothermal Therapy
Authors: Liang Jianying , Song Xiaoxia , Zhu Rongrong , Guo Dandan , Dai Wei 
Published: May 2022

Aim:
The main aim of this study is to improve the solubility, reduce side effects and increase the therapeutic
efficacy of CSL by using functionalized graphene oxide as a carrier, to fulfill chemo-photothermal therapy.

Background:
Celastrol (CSL), which is extracted from the traditional Chinese medicinal plant Tripterygium wilfordii,
has reported significant antitumor activity in vitro and in vivo cancer models. However, disadvantages with regard to
solubility, short plasma half-life and toxicity hinder its use in pharmaceutical application. Nanocarrier delivery system
could be employed to improve the biochemical and pharmacokinetic performance of CSL. Among numerous nanocarriers,
graphene oxide is one of the most promising nanocarriers due to its intrinsic physical and chemical properties and
good biocompatibility.

Objective:
Here, we employed a PEGylated reduced nanographene oxide CSL complex (nrGO-PEG/CSL) as a new
drug delivery system to achieve highly efficient synergistic chemo/photothermal therapy.

Methods:
A functionalized nrGO-PEG was synthesized and the loading capacity of CSL, photothermal effect and
release efficiency under different pH and NIR irradiation were measured in the first stage of work. In vitro and in vivo
anticancer effects of prepared nrGO-PEG/CSL complex were evaluated on 4T1 cells and 4T1 tumor-bearing mice,
respectively, with the association of NIR laser irradiation.

Results:
The functionalized nrGO-PEG exhibited excellent drug loading capacity of CSL (20.76 mg/mg GO) and
photothermal effect (~3.0 -fold increment over unreduced nGO-PEG). Loaded CSL could be efficiently released from
nrGO-PEG/CSL complex by NIR irradiation in vitro. In vivo study performed on 4T1 tumor-bearing mice proved that
nrGO-PEG/CSL with NIR laser irradiation shows superior anticancer effects.

Conclusion:
The experimental data demonstrated that the nrGO-PEG/CSL-mediated chemo/photothermal combination
therapy was more cytotoxic to cancer cells than only chemotherapy or photothermal treatment, reducing the occurrence
of tumor metastasis. Therefore, nrGO-PEG/CSL-mediated chemo/photothermal is expected to be a promising treatment
for synergistic cancer therapy.
A Generalized Review Of Human-Computer Interaction Using Electromyogram
Signals
Authors: Maity Sourav , Veer Karan 
Published: May 2022

Abstract:
The primary use of human computer interaction is in smart home as well as in industry 4.0. Communication between computer and human can be benefitted by a spontaneous interchange of emotions. The objective of the work is to provide an idea regarding the process of identifying various emotions using facial electromyography signals through electrode placement method. Here one contemplated the facial electromyography on masticatory function assessment and emotional articulation monitoring. Furthermore, we have also presented the measurement of facial electromyography including selection of electrode, location of electrode and reduction of noise. Facial emotions have significant effect on cognitive process of the human brain such as doubt perception, ability to solve problems, learning capabilities, emotional interactions and memory which is beneficial while interacting with patients suffering from depression and stress. The patients are guided through their rehabilitation process by rehabilitation application while accustoming itself to patient’s emotional state or wellbeing, which results in high motivation as well as in a quicker. This review paper will motivate and inspire researchers and engineers for finding more suitable system for various applications.
An Infrared and Visible Image Fusion Approach of Self-calibrated
Residual Networks and Feature Embedding
Authors: Dai Jinpeng , Luo Zhongqiang , Li Chengjie 
Published: May 2022

Background:
The fusion of infrared image and visible image has been a hot topic in the field of image fusion. In the process of image fusion, different methods of feature extraction and processing will directly affect the fusion performance.

Objectives:
Low resolution (small size) of high-level features will lead to the loss of spatial information. On the other side, the low-level features are not significant due to their insufficient filtering of background and noise.

Methods:
In order to solve the problem of insufficient feature utilization in existing methods, a new fusion approach (SC-Fuse) based on self-calibrated residual networks (SCNet) and feature embedding is proposed. The method improves the quality of image fusion from two aspects: feature extraction and feature processing.

Results:
First, self-calibrated modules are applied to the field of image fusion for the first time, which enlarged the receptive field to make feature maps contain more information. Second, we use ZCA (zero-phase component analysis) and l1-norm to process features, and propose a feature embedding operation to realize the complementarity of feature information at different levels.

Conclusion:
Finally, a suitable strategy is given to reconstruct the fused image. After ablation experiments and comparison with other representative algorithms, the results show the effectiveness and superiority of SC-Fuse.
The Effects of Overweight and Obesity on Obstacle Crossing During Walking: Protocol for a Systematic Review
Authors: Chardon Matthias , Barbieri Fabio Augusto , Penedo Tiago , Santos Paulo Cezar Rocha , Vuillerme Nicolas 
Published: May 2022

BackgroundOverweight and obesity are significant global health concerns that involve deficits in gait and balance that affect daily activities. Although much is reported about the effect of overweight and obesity on gait during unobstructed walking, not much is known about how overweight and obesity could impact gait under more challenging conditions, such as environments with obstacles.ObjectiveThe aim of this study is to systematically review and synthesize the available data regarding the effects of overweight and obesity on obstacle crossing during walking.MethodsThis review will follow the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guidelines. PubMed, Web of Science, Scopus, and SPORTDiscus will be systematically searched with no limitations on publication date. Only full-text English-language articles published in a peer-reviewed journal will be included. Included articles must have compared obstacle crossing during walking in individuals with overweight or obesity to individuals of normal body weight. A total of 2 independent reviewers will select the articles and extract the following 4 sets of data: (1) study characteristics, (2) sample description, (3) obstacle crossing task protocol, and (4) main results obtained. If a considerable number of homogeneous papers are included, a meta-analysis will be conducted. A preliminary search was conducted in November 2021.ResultsThe results will include the article selection flowchart as well as tables and figures synthesizing the extracted data on the effects of overweight and obesity on obstacle crossing during walking. The preliminary search identified 73 original records, of which 5 articles met the inclusion criteria.ConclusionsThis review will present researchers and clinicians with an overview of published studies that have compared the performance of obstacle crossing for individuals with overweight and obesity to those of normal body weight. Gaining insight into the control strategies adopted by individuals with overweight and obesity is critical for safe and successful obstacle crossing in this population. We therefore believe that our findings could be useful for identifying people at risk of falls and developing and implementing fall prevention programs for individuals with overweight and obesity.Trial RegistrationPROSPERO CRD42021269949; https://tinyurl.com/3yrwccu4International Registered Report Identifier (IRRID)DERR1-10.2196/36234
La Medicina del Viajero en República Dominicana
Authors: Castillo Santana Esmailyn , De Jesús Arámboles Yocastia , Catoia Varela Margareth , Bautista Branagan Claudio E. , Lara Reyes Eudy M. , Dias da Costa Marcellus 
Published: May 2022

Introducción: la especialidad Medicina del Viajero existe hace más de 40 años. Sin embargo, esta es prácticamente desconocida por los dominicanos a pesar de la gran cantidad de personas que viajan desde y hacia nuestro país.
Material y métodos: Con el objetivo de determinar el conocimiento de los dominicanos sobre la existencia de la Medicina del Viajero y sus actitudes en relación a esta, realizamos una encuesta virtual de 8 preguntas, de la cual participaron 2,584 dominicanos.
Resultados: a pesar de que más del 80 % de los encuestados sabían que para viajar a determinados países debían tomar ciertas vacunas, menos del 25 % había escuchado hablar de la especialidad Medicina del Viajero. Tras conocer la definición y objetivos de la especialidad más del 90 % de los participantes consideró importante realizar una consulta previa al viaje con un especialista.
Conclusión: el desconocimiento de la especialidad y la ausencia de este servicio en el sistema público de salud son las principales barreras para el acceso de los dominicanos a la consulta de Medicina del Viajero. Es necesario dar a conocer la especialidad, utilizando evidencia científica y tomando como ejemplo la difusión mundial de la COVID-19 a través de los viajeros, concienciar a la población de la importancia de la consulta pre y post viaje, así como la creación de este servicio en hospitales públicos.
Conocimientos, percepciones, necesidades y desafíos de los adolescentes dominicanos con Diabetes Mellitus Tipo 1
Authors: Moore de Peralta Arelis , Cepeda Jenny , Abreu Rodríguez Gabriela 
Published: May 2022

Introducción: el descontrol metabólico en pacientes con diabetes tipo 1 (DMT1) puede provocar complicaciones severas y reducir la esperanza de vida. La transición a la adolescencia en jóvenes con DMT1 determina cambios importantes que pueden influenciar negativamente el control metabólico.
Propósito: determinar el nivel de conocimiento, las percepciones, las necesidades y los desafíos de los adolescentes dominicanos con DMT1.
Metodología: entrevistas telefónicas a adolescentes con DMT1, entre 14 y 18 años. El análisis incluyó la codificación con base al Modelo de Creencias de Salud, utilizando NVivo, a través de un abordaje deductivo e inductivo.
Resultados: participantes reportaron un alto nivel de susceptibilidad percibida de sufrir complicaciones y una percepción de severidad asociada a una enfermedad incurable que causa complicaciones severas. En los factores modificadores se destacan determinantes sociales como el nivel socioeconómico de la familia y, en las variables externas, el rol de las redes de apoyo en el manejo de la enfermedad.
Conclusiones: se requieren intervenciones culturalmente relevantes para mejorar el control metabólico y los aspectos psicosociales en los adolescentes dominicanos con DMT1, como sería una aplicación móvil para el automanejo; además, incorporar las perspectivas, las realidades contextuales y los conocimientos de los adolescentes en las estrategias de educación terapéutica sobre la DMT1 favorecería su impacto.
Incidencia de cardiopatías congénitas en pacientes ingresados en la unidad de Neonatología del Hospital Infantil Robert Reid Cabral, 2016-2018
Authors: Mancebo García Pablo , Soriano Nathalie , Lazala Leyni E. , Contreras Elizabeth , Haché Caran , Malagón Lissette 
Published: May 2022

Introducción: las cardiopatías congénitas son alteraciones estructurales del corazón y/o grandes vasos que se desarrollan durante la embriogénesis, existe un aumento aparente de la incidencia de las cardiopatías congénitas (CC) en las investigaciones recientes, especialmente de las cardiopatías acianógenas, como la comunicación interventricular (CIV) e interauricular (CIA), así como en menor grado otras cardiopatías, como transposición de grandes vasos (TGV) y el síndrome de corazón izquierdo hipoplásico (SCIH).
Material y métodos: estudio observacional, descriptivo, transversal y retrospectivo sobre la incidencia de cardiopatías congénitas en pacientes ingresados en la Unidad de Neonatología del Hospital Infantil Robert Reid Cabral durante el período 2016-2018 (hasta la semana epidemiológica #38). La muestra fue de 76 pacientes (n=76).
Resultados: la incidencia de cardiopatías congénitas fue 4.97 %. El 59.2 % eran masculino. Mas de 65 % de pacientes procedían de la región este del país. La disnea representó más de 70 % de los motivos de consulta, seguida de cianosis. 35.5 % de las cardiopatías correspondieron a CIV, que fue la patología cardíaca congénita más frecuentemente presentada, seguida por CIA.
Conclusión: observamos una incidencia global de cardiopatías congénitas de 4.97 % con predominio en sexo masculino. Los pacientes procedían de la región este en más de la mitad de los casos, y presentaron con mayor frecuencia disnea como motivo de consulta. La incidencia más elevada de cardiopatía congénita fue la CIV.
Atipicidad en el hipotiroidismo congénito: síndrome de Kocher-Debré-Semelaigne. Reporte de caso
Authors: Pérez Gesen Cecilia , Fernández Patty Bonna Viviana , Olivares Torres Ana , Carvajal Martinez Francisco , Pedroso Vila Raiza , Masot Rangel Antonio , Navarrete Cabrera Juliette 
Published: May 2022

El síndrome de Kocher Debré Semelaigne (SKDS) se describe dentro de las formas clínicas atípicas asociadas al hipotiroidismo congénito (HC) severo, no tratado y de larga evolución, con manifestaciones de pseudohipertrofia muscular difusa y debilidad muscular predominantemente proximal, reversible al reemplazo con tiroxina. Es raro en países con programas de pesquisa neonatal.
Objetivo: reportar el caso de un niño con diagnóstico de HC por disembriogenesis (atireosis), que se mantuvo con mal control de la enfermedad durante el primer año de vida y manifestaciones miopáticas desde la etapa neonatal.
Resultados: se confirma el diagnóstico a través de estudios específicos, con evidencias de patrones miopáticos característicos. Se logra regresión clínica parcial a los nueve meses de mantener estabilidad de la TSH y las hormonas tiroideas (HT), coincidiendo con la normalización de la enzima de músculo creatinfosfoquinasa (CPK). A los 12 años de seguimiento, mantenía ligera hipertrofia de la musculatura de las extremidades superiores, dorsales y glúteos, a pesar de mantenerse eutiroideo.
Conclusiones: la presencia de hipertrofia muscular debe considerarse un dato clínico de sospecha de hipotiroidismo, aun con la implementación de los programas de pesquisa neonatal. Es posible la regresión parcial de la pseudohipertrofia muscular con el restablecimiento de la función tiroidea. Se debe tomar en cuenta en el diagnóstico diferencial de otras miopatías primarias.
The American Brodsky: A Research Overview
Authors: BERLINA ALEXANDRA 
Published: May 2022

AbstractA Russian-American poet and essayist, a Nobel laureate, Joseph Brodsky is hardly present on the map of American studies. The following overview attempts to provide materials for remedying this oversight. After all, though the overwhelming majority of Brodsky scholars are Slavists, valuable work on Brodsky in an American context has been done, and a substantial part of it has been published in English. After a short biographical excursion, the materials are assembled according to the following categories: “Brodsky in America,” “Brodsky and American Literature,” “Brodsky as an American Poet,” and “Brodsky's Self-Translations into English.” In 2016, twenty years after his death in New York, the time seems ripe for a reconsideration.
An Amateur “Sun Also Rises”
Authors: DAIKER DONALD A. 
Published: May 2022

Abstract
This is the first new edition of Hemingway's The Sun Also Rises since its publication in 1926. A visually attractive and readable volume, it includes useful material such as early drafts of the novel and the discarded opening chapter that Hemingway cut at the urging of F. Scott Fitzgerald. What is disappointing is what is missing, notably a statement of editorial principles, as well as footnotes elucidating dated references and now-obscure allusions. Unfortunately, this “new” Sun has been edited, not by scholars, not by the professionals whom Hemingway admired, but by amateurs—family members who have not bothered to keep current with Hemingway scholarship and criticism. Not only are “Works Cited” and “Suggestions for Further Reading” lacking; so is any recognition in editor Seán Hemingway's “Introduction” that new and persuasive readings of Sun have emerged in the last quarter century.
Mailer Unbound
Authors: BROER LAWRENCE R. 
Published: May 2022

Abstract
According to Fitzgerald, “There never was a good biography of a good novelist. There couldn't be. He is too many people if he's any good” (qtd. in Wilson, The Crack-Up 177). Yet it would be hard to imagine a better told writer's life than J. Michael Lennon's Norman Mailer (2013). When Mailer directed his friend and longtime scholar of his work to feel free to put in everything, Lennon did just that—at least everything relating to Mailer's work as psycho-autobiography. We knew Mailer's work was intensely personal, but now we know the unique nature of Mailer's fictional self-revelations; they are a continuous working out of complex psychological oppositions at the heart of what Lennon aptly calls Mailer's “double life.” Lennon's Mailer reads like one of Mailer's own absorbing journalistic books. It will prove invaluable to readers hoping better to understand and to evaluate the author's place in American literature.
A Forgotten Writer: Alice Beal Parsons and “Cross Purposes”
Authors: HOLMES SARAH C. 
Published: May 2022

Abstract
This essay recovers a socialist and feminist writer previously overlooked by literary scholars. An author of five novels and numerous short stories, Alice Beal Parsons published for both mainstream and progressive audiences. Of particular note is her membership in the Communist Labor Party and her renunciation of a bourgeois identity. The archival discovery “Cross Purposes” is a good representation of her commitment to radicalism. Most likely composed in the 1920s or 1930s, the short story is a unique examination of a wealthy woman's role in the oppression of the women who work for her. Included with a full transcription of the story is a bibliography of Parsons's major work.
Too Much of a Good Thing Is Wonderful: At Long Last, Cather's Letters
Authors: LINDEMANN MARILEE 
Published: May 2022

Abstract
This review essay explores the profound scholarly significance of the publication of The Selected Letters of Willa Cather, a nearly 700-page collection scrupulously edited by Andrew Jewell and Janis Stout (Knopf, 2013). The volume contains 566 full-text transcriptions selected from the 3,000 Cather letters now known to exist and makes them accessible in print for the first time. Cather's will, executed in 1943, forbade not only publication of her letters but even direct quotation from them, so biographers and critics for decades engaged in a kind of shadowboxing as they sought to convey Cather's thoughts and feelings through the awkward constraint of paraphrase. Now that the testamentary restrictions have been lifted and this volume is available, scholars and fans can hear Cather's epistolary voice without traveling to archives. An extraordinary contribution to Cather studies, the Selected Letters offers much to anyone interested in twentieth-century American literature, women writers, or LGBT/queer studies.
Perancangan Chatbot Islami untuk Aplikasi ChatAja
Authors: Pratama Nanda Yusuf Nur , Al Irsyadi Fatah Yasin 
Published: May 2022

ChatAja adalah platform komunikasi karya anak bangsa yang dibuat untuk melengkapi gaya hidup digital dengan menyediakan layanan pesan instant, pesan suara, dan panggilan video gratis. ChatAja dirilis ke publik pada bulan februari 2020 dan dapat diinstall di ponsel android maupun iphone. Seperti kebanyakan aplikasi pesan instant ChatAja juga memiliki fitur chatbot. Chatbot adalah program komputer yang diprogram untuk dapat membalas pesan pengguna secara otomatis dan natural. Ada banyak chatbot yang telah dibuat oleh tim ChatAja dengan berbagai kegunaan untuk membantu penggunanya. Karena merupakan aplikasi yang tergolong baru ChatAja memerlukan banyak inovasi agar dapat diterima oleh masyarakat. Oleh karena itu untuk menyambut datangnya bulan suci ramadhan ChatAja ingin membuat sebuah chatbot yang dapat membantu penggunanya dalam menjalankan ibadah di bulan suci ramadhan. Penelitian ini bertujuan untuk mengembangkan sebuah chatbot sebagai media promosi aplikasi ChatAja dan juga untuk membantu penggunanya memeriahkan bulan suci ramadhan. Chatbot ini dirancang dengan menggunakan bahasa pemrograman javascript dengan framework Node JS untuk chatbot, bahasa pemrograman Ruby dengan framework Ruby on Rails untuk web admin dari chatbot dan Postgree SQL sebagai sistem manajemen basis data. Pengembangan chatbot ini menggunakan metode waterfall dengan tahapan analisis kebutuhan, perancangan sistem, pembuatan sistem, pengujian sistem, implementasi dan perawatan sistem. Dalam pengembangannya chatbot memiliki 4 fitur utama yaitu adzan checker, onde day one ayat, kuis ramadhan dan reminder. Berdasarkan hasil pengujian blackbox dan UAT dapat disimpulkan bahwa sistem berjalan dengan normal serta memperoleh hasil rata-rata persentase dari responden sebesar 84,4%. Dari pengujian tersebut dapat disimpulkan bahwa sistem dapat digunakan sebagai media promosi aplikasi ChatAja Messanger.
Sistem Pendukung Keputusan Seleksi Penerima Program Bantuan Sosial Menggunakan Metode SAW
Authors: Tika Muhibah Fata 
Published: May 2022

Bantuan sosial merupakan salah satu cara pemerintah untuk menanggulangi kemiskinan yang bertujuan agar terpenuhinya kebutuhan masyarakat dengan ekonomi rendah dan meningkatkan taraf hidup penerima bantuan sosial. Proses penentuan penerima bantuan sosial di Desa Sroyo masih menggunakan cara manual yaitu dengan mengisi formulir dalam bentuk kertas dan diseleksi satu persatu sehingga membutuhkan waktu relatif lama dan kurang optimal. Jika semakin banyak kertas yang menumpuk maka data akan lebih rentan rusak dan hilang. Untuk mengatasi permasalahan tersebut perlunya sistem yang dapat mempermudah proses seleksi penerima bantuan sosial di Desa Sroyo dalam hal ini yaitu sistem pendukung keputusan yang didukung dengan metode Simple Additive Weighting (SAW). Pengembangan sistem pendukung keputusan ini dikembangkan dengan metode waterfall menggunakan bahasa pemrograman PHP (PHP: Hypertext Preprocessor), Framework Code Igniter 3 serta database MySQL sebagai database server. Dari hasil perhitungan menggunakan metode SAW diperoleh rekomendasi nama-nama penerima program bantuan sosial berdasarkan perankingan. Selain itu berdasarkan hasil pengujian blackbox sistem ini berjalan sesuai dengan fungsinya.