bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jejunum-derived NF-κB reporter organoids as 3D models for the study of TNF-alpha-induced inflammation
Authors: Daghero Hellen , Doffe Flora , Varela Belén , Yozzi Victoria , Verdes José Manuel , Crispo Martina , Bollati-Fogolín Mariela , Pagotto Romina 
Published: August 2022

AbstractInflammation is an important process for epithelial barrier protection but when uncontrolled, it can also lead to tissue damage. The nuclear factor-kappa light chain enhancer of activated B cells (NF-κB) signaling pathway is particularly relevant in the intestine, as it seems to play a dual role. Whereas NF-κB protects intestinal epithelium against various noxious stimuli, the same pathway mediates intestinal inflammatory diseases by inducing pro-inflammatory gene expression. The availability of appropriate in vitro models of the intestinal epithelium is crucial for further understanding the contribution of NF-κB in physiological and pathological processes and advancing in the development of drugs and therapies against gut diseases. Here we established, characterized, and validated three-dimensional cultures of intestinal organoids obtained from biopsies of NF-κB-RE-Luc mice. The NF-κB-RE-Luc intestinal organoids derived from different intestine regions recreated the cellular composition of the tissue and showed a reporter responsiveness similar to the in vivo murine model. When stimulated with TNF-α, jejunum-derived NF-κB-RE-Luc-reporter organoids, provided a useful model to evaluate the anti-inflammatory effects of natural and synthetic compounds. These reporter organoids are valuable tools to explore the epithelial TNF-α-induced NF-κB contribution in the small intestine, being a reliable alternative method while helping to reduce the use of laboratory animals for experimentation.
Selective serotonin reuptake inhibitors increase risk of upper gastrointestinal bleeding when used with NSAIDs: a systemic review and meta-analysis
Authors: Alam Syed Mobashshir , Qasswal Mohammed , Ahsan Muhammad Junaid , Walters Ryan W. , Chandra Subhash 
Published: August 2022

AbstractThe use of selective serotonin reuptake inhibitors (SSRIs) can increase the risk of gastrointestinal (GI) bleeding. Similarly, it is well known that the use of NSAIDs predisposes patients to upper GI bleeding. The aim of this study was to explore if the addition of SSRIs in patients already taking NSAIDs significantly increases their risk for upper GI bleeding. An electronic literature search was conducted using the SCOPUS and MEDLINE databases from inception through September 2020. Cohort and case–control trials that reported patients with upper GI bleeding on NSAIDs with SSRIs, compared to controls on NSAIDs only were included. Newcastle–Ottawa checklist was used to ensure inclusion of high-quality studies. Data was extracted by the lead investigator and cross-checked by the second author. Dichotomous data was pooled to obtain an odds ratio (OR) of the risk of upper GI bleeding in patients on NSAIDs with concomitant SSRI use. The primary endpoint of the study was the risk of upper GI bleeding with SSRIs and NSAIDs compared to NSAIDs alone. A total of 366 citations were reviewed, and 21 were selected for full-text evaluation. 1 cohort and 9 case–control studies were eligible. There was an additional increased risk of upper GI bleeding in patients on NSAIDs with concomitant SSRI use (OR 1.75, 95% CI = 1.32–2.33). In patients already on NSAID therapy, the concomitant use of SSRIs can significantly increase the risk of upper of GI bleeding.
Controllable synthesis of sphere-shaped interconnected interlinked binder-free nickel sulfide@nickel foam for high-performance supercapacitor applications
Authors: Al-Abawi Batool Taher , Parveen Nazish , Ansari Sajid Ali 
Published: August 2022

AbstractThe fabrication of energy storage electrode materials with high specific capacitance and rapid charge–discharge capability has become an essential and major issue of concern in recent years. In the present work, sphere-shaped interconnected interlinked binder-free nickel sulfide (NiS) grown on the surface of a three-dimensional nickel foam (3DNF) was fabricated by a one-step solvothermal method under optimized synthesis conditions, including different solvents, amounts of sulfur, and experimental reaction times. The fabricated binder-free SS-NiS@3DNF-E electrodes were characterized by a range of spectroscopic and microscopic techniques and further evaluated for their comparative electrochemical supercapacitive performance in half-cell assembly cells. The optimized sphere-shaped interconnected interlinked binder-free SS-NiS@3DNF-E-3 electrode showed an outstanding specific capacitance of 694.0 F/g compared to SS-NiS@3DNF-E-1 (188.0 F/g), SS-NiS@3DNF-E-2 (470.0 F/g), and SS-NiS@3DNF-E-4 (230.0 F/g) as well as excellent cycling stability up to 88% after 6700 continuous charge–discharge cycles, with an energy density of 24.9 Wh/kg at a power density of 250.93 W/kg. The obtained results demonstrate that the interconnected interlinked binder-free NiS@nickel electrode is a potential candidate for energy storage applications.
STING-pathway modulation to enhance the immunogenicity of adenoviral-vectored vaccines
Authors: Padron-Regalado Eriko , Ulaszewska Marta , Douglas Alexander D. , Hill Adrian V. S. , Spencer Alexandra J. 
Published: August 2022

AbstractTraditional chemical adjuvants remain a practical means of enhancing the immunogenicity of vaccines. Nevertheless, it is recognized that increasing the immunogenicity of viral vectors is challenging. Recently, STING ligands have been shown to enhance the efficacy of different vaccine platforms, but their affectivity on viral-vectored vaccination has not been fully assessed. In this study we used a multi-pronged approach to shed light on the immunological properties and potential mechanisms of action of this type of adjuvant and focused our study on replication-deficient human adenovirus serotype 5 (AdHu5). When the STING ligand 2′3′-cGAMP was mixed with AdHu5, the adjuvant enhanced anti-vector immune responses while decreasing the transgene-specific CD8+ T cell response. Studies employing STING-knockout mice and a 2′3′-cGAMP inactive analogue confirmed the aforementioned effects were STING dependent. In vitro assays demonstrated 2′3′-cGAMP induced the production of IFN-β which in turn negatively affected AdHu5 transgene expression and CD8+ T cell immunogenicity. In an effort to overcome the negative impact of early 2′3′-cGAMP signaling on AdHu5 transgene immunogenicity, we generated a bicistronic vector encoding the 2′3′-cGAMP together with a model antigen. Intracellular production of 2′3′-cGAMP after AdHu5 infection was able to enhance transgene-specific CD8+ T cell immunogenicity, although not to a level that would warrant progression of this adjuvant to clinical assessment. This work highlights the importance of timing of 2′3′-cGAMP administration when assessing its adjuvant capacity with different vaccine modalities.
Positional relationship between lacrimal sac and skull base: implication of risk of cerebrospinal fluid leakage during dacryocystorhinostomy
Authors: Kono Shinjiro , Vaidya Aric , Naito Munekazu , Nakano Takashi , Ito Makoto , Kakizaki Hirohiko , Takahashi Yasuhiro 
Published: August 2022

AbstractCerebrospinal fluid (CSF) leakage is a rare but severe complication during dacryocystorhinostomy (DCR). Understanding the details of the anatomy of the lacrimal drainage system and skull base is essential to avoid this complication. We examined the positional relationship between the lacrimal sac and skull base using 16 cadavers (22 sides) and using computed tomographic images taken in 81 patients (81 sides). Consequently, the frontal sinus intervened between the lacrimal sac and skull base in 81.8–90.1% of cases. The lacrimal sac fundus and posterior lacrimal crest were far from the skull base/cribriform plate, and the skull base above the lacrimal sac was considerably thick. These results indicate that the risk of skull base injury and consequent CSF leakage during DCR is extremely low. However, surgeons should be cautious of this complication by indirect injury due to a twisting movement of a bone rongeur applied to the maxillary bone during creation of a bony window in patients with no interposition of the frontal and ethmoid sinuses between the lacrimal sac and skull base.
FBP1 knockdown decreases ovarian cancer formation and cisplatin resistance through EZH2-mediated H3K27me3
Authors: Xiong Xifeng , Lai Xudong , Zhang Jinli , Meng Qingqi , Wang Pengzhen , Qin Shengnan , Liu Wei , Wang Yongxuan , Yao Zhuo , Wang Di , Li Xiaojian , Liu Zhihe , Miao Haixiong 
Published: August 2022

Abstract
Worldwide, ovarian cancer (OC) is the seventh common cancer and the second most common cause of cancer death in women. Due to high rates of relapse, there is an urgent need for the identification of new targets for OC treatment. The far-upstream element binding protein 1 (FBP1) and enhancer of zeste homolog 2 (EZH2) are emerging proto-oncogenes that regulate cell proliferation and metastasis. In the present study, Oncomine data analysis demonstrated that FBP1 was closely associated with the development of OC, and The Cancer Genome Atlas (TCGA) data analysis indicated that there was a positive correlation between FBP1 and EZH2 in ovarian tissues. Moreover, we found that FBP1 knockdown suppressed tumor formation in nude mice and cisplatin resistance of OC cells, but the role of FBP1 in the cisplatin resistance of OC cells remained unclear. In addition, we verified physical binding between FBP1 and EZH2 in OC cells, and we demonstrated that FBP1 knockdown enhanced cisplatin cytotoxicity in OC cells and down-regulated EZH2 expression and trimethylation of H3K27. These results suggested that FBP1 increases cisplatin resistance of OC cells by up-regulating EZH2/H3K27me3. Thus, FBP1 is a prospective novel target for the development of OC treatment.
The minimum number of discriminant equations for a symmetric game
Authors: Wang Lei , Liu Xinyun , Li Ting , Zhu Jiandong 
Published: August 2022

AbstractThe discriminant equations with the minimum number for a symmetric game are derived. By using a new version of the semi‐tensor product method based on adjacent transpositions, the analysis of symmetric games is greatly simplified. Some new necessary and sufficient conditions for symmetric games are proposed, a basis of the symmetric game space is easily calculated, and the computing complexity is achieved. Finally, two examples are displayed to show the effectiveness of the proposed method.
HSLS: An efficient local search algorithm for the hardware and software partitioning problem
Authors: Tian Xinliang , Ouyang Dantong , Zhou Huisi , Jiang Luyu , Zhang Liming 
Published: August 2022

AbstractHardware and software partitioning (HW/SW) is a crucial step in the co‐design of embedded systems, which is a typical combinatorial optimisation problem. In practice, HW/SW instances would be of large scale, so it is of significant importance to design effective heuristic algorithms to obtain a high‐quality partitioning scheme. Different from previous heuristics, the HW/SW problem is treated as the minimum weight dominating set (MWDS) problem in this letter, and the mature local search framework for solving the MWDS problem is introduced to solve the HW/SW problem. In addition, two suitable vertex selection rules based on scoring function and tabu are proposed. Combined with the introduced local search framework, an efficient local search algorithm named HSLS is obtained. 96 classic benchmark instances are used to evaluate the performance of the HSLS algorithm, and the four latest evolutionary algorithms designed for the HW/SW problem are used as comparison algorithms, which are genetic algorithm, binary particle swarm optimisation, differential evolution, and group theory‐based optimisation algorithm. The experimental results show that the HSLS algorithm is far superior to the four comparison algorithms in terms of the optimal solution and obtains optimal solution on 78 benchmark instances, the four comparison algorithms obtain 43, 29, 42, and 41 optimal solutions respectively.
Synchronous reluctance machines with new type of fractional‐slot concentrated‐windings based on the concept of stator slot shifting
Authors: Taghavi Araghi Seyed Mahdiar , Kiyoumarsi Arash , Mirzaeian Dehkordi Behzad 
Published: August 2022

AbstractFractional‐slot concentrated‐windings are appreciated for their simple construction, short end‐winding length, high copper fill factor, low cogging torque, good field‐weakening capability and fault‐tolerant ability. However, in comparison to the conventional distributed windings, the fractional‐slot concentrated‐windings are characterised with high space magnetomotive force (MMF) harmonics, which results in undesirable effects on the machine performance, such as localised core saturation, eddy current loss in the rotor and noise and vibration. In order to improve winding characteristics, several techniques have been developed recently. This manuscript introduces the 5 new winding topologies by using the general concept of stator slot shifting. It means that, in order to cancel undesirable MMF harmonics, by doubling (or tripling or even multiplying) the slot number and dividing the winding and then relatively shifting the winding by one (or more) slots, the undesirable harmonics have been eliminated effectively. The best choice is chosen according to the lowest amount of the MMF harmonic, highest value of winding factor and torque desirable characteristics. At the end, comprehensive comparisons for the designed synchronous reluctance motor (SynRel) equipped with proposed windings and also distributed winding are presented. The analytical study and 2D FEM analysis results show that it is possible to get an ideal low space‐harmonic winding topology, and consequently, a low torque ripple for these motors.
Inversion detection method of oil‐immersed transformer abnormal heating state
Authors: Deng Yongqing , Ruan Jiangjun , Dong Xuzhu , Huang Daochun , Zhang Chen 
Published: August 2022

AbstractTransformer overheating faults have an important impact on the transformer safe and stable operation. Taking 10 kV oil‐immersed transformer as the research object, using the indirect coupling analysis method of electromagnetic thermal fluid multi‐physical field, the transformer heating characteristics under overheating faults, such as winding inter‐turn short circuit and core multi‐point grounding, are analysed, and the transformer abnormal heating state identification method is proposed based on the inversion of transformer top oil temperature rise. By inverting the transformer normal top oil temperature rise under different load rates and comparing it with the actual measured value, taking into account the top oil temperature rise inversion error, it is determined that when the top oil temperature rise measured value is higher than the inversion value by 2.9 K, it indicates the transformer is in an abnormal heating state, and the higher the deviation degree is, the deeper the degree of abnormal heating fault. The accuracy of the transformer abnormal heating state identification method is verified by the multi‐working condition temperature rise test, which can provide a certain reference for the detection and maintenance of transformer abnormal internal heating faults.
Multi‐functional control strategy for power quality improvement of three‐phase grid using solar PV fed unified power quality conditioner
Authors: Sanjenbam Chandrakala Devi , Shah Priyank , Singh Bhim 
Published: August 2022

AbstractThis article presents a generalised integrator with a band‐pass filter frequency locked loop (GI‐BPF‐FLL) control algorithm for the solar photovoltaic (SPV)‐integrated unified power quality conditioner (SPVUPQC) system. This control algorithm extracts fundamental components (FC) of the distorted and deformed input signals, and it has the competence of eliminating DC‐offset. The key objective is to decrease the number of sensors used in the control algorithm of the SPVUPQC system while enabling the power quality enhancement features in the distribution grid. The effectiveness of the presented GI‐BPF‐FLL control algorithm and its performance comparison with the conventional control algorithm are discussed in both the time domain as well as frequency domain analysis. The SPVUPQC system consisting of a distribution static compensator (DSTATCOM) and a dynamic voltage restorer (DVR), to compensate simultaneously both the voltage distortions, sag/swell etc. as well as current harmonics, reactive power and load currents unbalances etc. The model of the SPVUPQC system is developed in the MATLAB/Simulink environment, and its results are presented to demonstrate its capabilities. The system's validation is also done on the hardware prototype, and it performs effectively for the voltage and current power quality enhancement simultaneously. The load side voltages magnitudes, grid side voltages and the grid currents total harmonic distortions are found within the boundaries specified in the IEEE standard 1159 and the IEEE standard 519.
A feedback‐integrated framework for resilient and distributed scheduling of electric vehicles under uncertain charging characteristics
Authors: Kandpal Bakul , Verma Ashu 
Published: August 2022

AbstractEmerging innovation in smart charging for plug‐in electric vehicles (EVs) has the potential to achieve significant economic benefits. In several works, smart charging encourages the use of EVs as a flexible resource by modifying their power consumption through a demand response (DR) program. However, it is promptly assumed that EVs are always responsive and accept the smart charging signals with no fault. In practice, due to uncertainties such as random EV mobility, volatile battery charging characteristics or charging component failures, some EVs would be unable to accept the assigned charging signals dispatched from a central server. Therefore, this article proposes a feedback loop to predict EV charging behaviours and thereby adaptively tune the time‐based control signals dispatched to individual EVs. Moreover, a parallel‐operating distributed DR algorithm is proposed which aims optimal EV scheduling under charging uncertainties while reducing the need of private information sharing. The proposed distributed algorithm allows increased EV user privacy, fast convergence properties and optimal operation under communication disruptions and delays. The effectiveness of the proposed methods are also numerically exhibited for varying penetration of EVs within a low‐voltage (LV) distribution test network.
Predicting liver disorder based on machine learning models
Authors: Zhao Jing , Wang Peixia , Pan Yubiao 
Published: August 2022

AbstractAs the main detoxification organ of human body, liver is very important in humans' health by metabolizing a lot of substances that are taken in, including alcohol and the medicine. However, if a person consumes too much alcohol or contaminated food, it will lead to liver disorder by causing little ingestion of essential nutrients. Accurate prediction for alcohol consumption, therefore, is very important by providing doctors the necessary information for diagnosing liver diseases. To address this problem, this paper introduces machine learning models to predict liver disorder. In addition, to alleviate the influence of data randomness by splitting the data set into a training set and a testing set, the leave‐one‐out cross valuation is utilized. The feature importance and the relationships between different features are also analyzed. The experimental results showed that the machine learning models are effective for alcohol consumption prediction. Among them, the random forest has the best performance in terms of accuracy (80.35%). The reason could be that the ensemble strategy used is helpful to reduce the over‐fitting problem caused by the imbalanced data set. This indicates that the random forest could be a useful tool for liver disorder prediction by providing helpful information or suggestions for doctors for diagnosing liver diseases.
Adipositas im Kindesalter – Ergebnisse einer empirischen
Untersuchung in Greifswald
Authors: Boshkov Vlatko , Schmitz Mia , Scheer Dirk , Schiel Ralf , Fleßa Steffen 
Published: August 2022

Zusammenfassung
Zielsetzung Übergewicht und Adipositas von Kindern stellt ein
schwerwiegendes Gesundheitsproblem dar. In der Literatur werden
Übergewicht und Adipositas von Kindern häufig mit niedrigem
sozioökonomischen Status (SES) und Migrationshintergrund
begründet, so dass Präventionsprogramm sich auf diese
Zielgruppen konzentrieren können.
Methodik In Kindergärten und Horts in der Stadt Greifswald wurden
250 Kinder zufällig ausgewählt und in die Studie einbezogen. Mit
Hilfe von getrennten Fragebögen der Eltern und Kinder, die durch eine
Treuhandstelle unter Wahrung der Anonymität zusammengeführt
wurden, wurde für jedes Kind der SES, die Gewichtskategorie, der
Migrationshintergrund sowie das Ess- und Freizeitverhalten erhoben. SES und
andere Variablen wurden mit der Gewichtskategorie assoziiert.
Ergebnisse Die Prävalenz von Übergewicht und Adipositas ist
insbesondere um die Einschulung herum besonders hoch. Weder Einkommen noch
Bildung oder Migrationshintergrund sind signifikant mit der Gewichtskategorie
verbunden. Lediglich der Berufsstatus der Eltern ermöglicht eine
verlässliche Aussage über das Gewicht der Kinder. Der
Zusammenhang von Ess- bzw. Freizeitverhalten und Gewicht ist hingegen
erwartungsgemäß.
Schlussfolgerung Auf Grundlage dieser Analysen lässt sich keine
spezifische Zielgruppe festlegen, auf die ein zielgerichtetes
Präventionsprogramm ausgelegt sein könnte. Vielmehr erscheint es
wichtig, im 6. und 7. Lebensjahr das Ess- und Freizeitverhalten besonders zu
beachten, insbesondere in der ersten Schulklasse. Die besondere Situation in der
kleinen Universitätsstadt Greifswald mit vergleichsweise vielen
Gastwissenschaftler*innen und ausländischen Studierenden
könnte erklären, warum der Migrationshintergrund hier keine
Rolle in der Erklärung des Gewichtes der Kinder spielt.
SO2-Extrusive 1,4-(Het)Aryl Migration: Synthesis of α-Aryl Amides and Related Reactions
Authors: Guérinot Amandine , Cossy Janine , G.-Simonian Nicolas 
Published: August 2022

Abstract(Het)aryl migration has emerged as a key synthetic tool and has particularly been exploited for the synthesis of α-aryl amides. This method overcomes the existing α-arylation methods, which are not always compatible with the introduction of (het)aryl groups possessing bulky or electrophilic substituents. This review focuses on SO2-extrusive (het)aryl migration in the frame of α-aryl amide synthesis. Anion- and radical-mediated transformations are reported, including the synthesis of polycyclic compounds through cascade reactions.1	Introduction2	Anionic Aryl Migration3	Radical Aryl Migration4	Conclusion