bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel lookup table based model predictive torque control strategy using matrix converter suitable for permanent magnet synchronous motor fed marine electric propulsion drives
Authors: Joshua Dasamma Anunciya , Arumugam Sivaprakasam 
Published: May 2022

AbstractMatrix converter (MC), an embryonic stage AC–AC converter with dynamic potentialities which is well suitable for the efficient propulsion and better maneuverability of marine vehicles with ensured power quality. The increased number of voltage vectors in MC facilitates a vibrant control over the propulsion motor and also the compactness in MC structure is a desirable aspect. The MC fed finite control set‐model predictive control (FCS‐MPC) is an attractive and effective modern concept of motor control. However, the industrial implementation of MC fed FCS‐MPC is immature due to its necessity of powerful and expensive processors, as it employs more prediction voltage vectors which correspondingly increase the execution duration of the control algorithm. Hence, this paper presents an efficient 12 sector based lookup table for the optimization and reduction of prediction voltage vectors in the FCS‐MPC without complicating the computation processing, which is suitable for the permanent magnet synchronous motor drive embedded in the marine propulsion unit. The effectiveness of the proposed algorithm is analyzed using the MATLAB environment and its steady state, dynamic and transient performances are investigated and validated using the real time OPAL RT lab system in comparison to the conventional methods. The significant idea behind this article is to propose a superior MC fed FCS‐MPC concept for the marine propulsion motors with diminished torque and flux ripples, which can be easily implemented with economically feasible processors.
An investigation into the impact of graphene nanoplatelets reinforced with glass fiber reinforced polymer composite on the hole quality using abrasive water jet drilling
Authors: Thakur Raju Kumar , Singh Kalyan Kumar 
Published: May 2022

AbstractGlass fiber reinforced polymer (GFRP) composites are being increasingly used in various industries owing to their low cost, lightweight, and impressive mechanical properties. For the present study, composites were fabricated with various weight percentages of graphene nanoplatelets (GNPs), i.e., 0, 0.125, 0.25, 0.375, and 0.5 wt%, which were mixed with epoxy resin of GFRP. Characteristics such as flexural strength, interlaminar shear strength (ILSS), and tensile strength of the prepared composites were tested, which established that reinforcement of 0.25 wt% of GNPs ensures optimum properties in the composite. The GNPs, loaded with 0.375 and 0.5 wt% agglomerated, on the other hand, showed interface‐governed failure. The influence of machining factors, such as wt% of GNPs, jet pressure, and traverse rate, were also studied to assess the hole quality of the composite samples, machined by abrasive water jet (AWJ). Subsequently, machining characteristics of the GNPs loaded GFRP composites are explored in detail using AWJ drilling in terms of surface roughness (Ra), kerf angle (KA), and entry and exit delamination factor (DF). The AWJ machining outcomes demonstrated that the incorporation of GNPs significantly influences the machining response of the composites. The Ra, KA, entry, and exit DF of composite laminates reduce with advancement in GNPs loadings. In addition, the surface of the drilled holes was characterized using FESEM analysis.
Registration of three Gossypium barbadense L. American pima‐like germplasm lines (PSSJ‐FRP01, PSSJ‐FRP02, and PSSJ‐FRP03) with improved resistance to Fusarium wilt race 4 and good fiber quality
Authors: Ulloa Mauricio , Abdurakhmonov Ibrokhim Y. , Hutmacher Robert , Schramm TariLee , Shermatov Shukhrat , Buriev Zabardast , Roberts Philip , Ellis Margaret L. , Payton Paxton 
Published: May 2022

AbstractOver the past 18 yr, Fusarium wilt race 4 (FOV4) has affected cotton (Gossypium spp.) production in the San Joaquin Valley of California, and more recently this pathogen was formally identified in 2017 in the El Paso, TX, region and in 2019 in New Mexico. The primary purpose for the germplasm release is to provide cotton breeders with needed alternative sources for continuing to improve FOV4 resistance in pima cotton. PSSJ‐FRP01 (Reg. no. GP‐1107, PI 699963) (PS‐592) originated from Pima S‐6 × G. barbadense pool accessions GB1368/k‐7616. Pima S‐6 possesses a major gene(s) for FOV4 resistance. GB1368/k‐7616 is Uzbekistan accession introduction with different plant structure, large leaves, columnar growth, and a more clustered fruiting habit when compared to most American pima. PSSJ‐FRP02 (Reg. no. GP‐1108, PI 699964) and PSSJ‐FRP03 (Reg. no. GP‐1109, PI 699965) originated from PS‐592 × SA‐3208 (LIAO MIAN 7 HAO). SA‐3208 is moderately resistant to FOV4. Multiple selections and recurrent cycles of selections were applied to these new germplasm lines based on an asymptomatic single plant after greenhouse FOV4 inoculations and/or infested field evaluations from F1 to F4. In subsequent field and greenhouse tests in 2019–2021, the germplasm lines showed improved resistance to FOV4 based on low percentage mortality and vascular staining and fiber quality when compared to commercial cultivars. PSSJ‐FRP01, PSSJ‐FRP02, and PSSJ‐FRP03 lines will help to continue reducing the vulnerability of the pima cotton industry to this fungal pathogen and to advance efforts to broaden the genetic base of FOV4 resistance, which is critical to the pima cotton industry in the United States and Uzbekistan.
Cracking chromatin with proteomics: From chromatome to histone modifications
Authors: Sigismondo Gianluca , Papageorgiou Dimitris N. , Krijgsveld Jeroen 
Published: May 2022

AbstractChromatin is the assembly of genomic DNA and proteins packaged in the nucleus of eukaryotic cells, which together are crucial in regulating a plethora of cellular processes. Histones may be the best known class of protein constituents in chromatin, which are decorated by a range of post‐translational modifications to recruit accessory proteins and protein complexes to execute specific functions, ranging from DNA compaction, repair, transcription, and duplication, all in a dynamic fashion and depending on the cellular state. The key role of chromatin in cellular fitness is emphasized by the deregulation of chromatin determinants predisposing to different diseases, including cancer. For this reason, deep investigation of chromatin composition is fundamental to better understand cellular physiology. Proteomic approaches have played a crucial role to understand critical aspects of this complex interplay, benefiting from the ability to identify and quantify proteins and their modifications in an unbiased manner. This review gives an overview of the proteomic approaches that have been developed by combining mass spectrometry‐based with tailored biochemical and genetic methods to examine overall protein make‐up of chromatin, to characterize chromatin domains, to determine protein interactions, and to decipher the broad spectrum of histone modifications that represent the quintessence of chromatin function.
Effect of celery (Apium graveolens) seed extract on hypertension: A randomized, triple‐blind, placebo‐controlled, cross‐over, clinical trial
Authors: Shayani Rad Maryam , Moohebati Mohsen , Mohajeri Seyed Ahmad 
Published: May 2022

AbstractIn the present work, the antihypertensive effects of celery seed extract (Apium graveolens) with active ingredients, such as 3‐n‐butylphthalide, were studied as a drug supplement in the treatment of hypertension. This study was a randomized, triple‐blind, placebo‐controlled, cross‐over clinical trial. Fifty‐two patients were divided into two groups (celery and placebo) and completed the two‐step clinical trial. Four celery seed extract capsules (totally 1.34 g per day) or 4 placebo capsules per day were administered to the patients during a 4‐week clinical trial. The blood pressure was assessed using a 24‐hr ambulatory blood pressure monitoring method. In celery group, systolic blood pressure changed from 141.2 ± 5.91 to 130.0 ± 4.38 mmHg (p < .001) while diastolic blood pressure changed from 92.2 ± 5.74 to 84.2 ± 4.87 mmHg (p < .001). Moreover, the mean arterial blood pressure changed from 108.5 ± 5.76 to 99.5 ± 4.66 mmHg (p < .001), and pulse pressure decreased from 49.0 ± 6.21 to 45.8 ± 6.01 mmHg (p < .01). However, no significant changes were observed in placebo group in terms of the above‐mentioned parameters (p > .05). Furthermore, no significant side effect was reported in the celery group, compared to the placebo group (p > .05). The results were promising and indicated the therapeutic effects of celery seed extract as a supplement in the management of hypertension.
Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans
Authors: Zhang Xiaofeng , Deng Jinlan , Tang Yujun , Guan Xiaoxian , Chen Xiaoli , Fan Jianming 
Published: May 2022

AbstractThis umbrella review is to recapitulate and grade the available evidence of associations between consumption of Zingiberaceae plants/curcumin (Cur) and multiple health‐related outcomes. This study included 161 meta‐analyses of randomized controlled trials in 76 articles with 67 unique health outcomes. Data on heterogeneity and publication bias are considered to assess the quality of evidence. Based on the different impact of Zingiberaceae plants/Cur on human health, the advantages outweigh the disadvantages. Zingiberaceae plants/Cur can mainly improve metabolic syndrome, non‐alcoholic fatty liver disease, cardiovascular disease, and some chronic inflammatory diseases, likewise, obviously relief the pain of osteoarthritis and related diseases. Ginger supplements have been shown to improve vomiting during pregnancy and to relieve nausea and vomiting caused by chemotherapy and surgery. The surgery is any type of surgery, including laparoscopic surgery, gynecological surgery and mixed surgery. Beneficial associations were found with Cur intervention in gastrointestinal, neurological and oral diseases. Zingiberaceae plants/Cur are generally safe and favorable for multiple health outcomes in humans. High‐quality research is further needed to prove the observed associations.
Processing and interpretation of core‐electron XPS spectra of complex plasma‐treated polyethylene‐based surfaces using a theoretical peak model
Authors: Bruggeman Marc , Zelzer Mischa , Dong Hanshan , Stamboulis Artemis 
Published: May 2022

Interpretation of X‐ray photoelectron spectroscopy (XPS) spectra of complex material surfaces, such as those obtained after surface plasma treatment of polymers, is confined by the available references. The limited understanding of the chemical surface composition may impact the ability to determine suitable coupling chemistries used for surface decoration or assess surface‐related properties like biocompatibility. In this work, XPS is used to investigate the chemical composition of various ultra‐high‐molecular‐weight polyethylene (UHMWPE) surfaces. UHMWPE doped with α‐tocopherol or functionalised by active screen plasma nitriding (ASPN) was investigated as a model system. Subsequently, a more complex combined system obtained by ASPN treatment of α‐tocopherol doped UHMWPE was investigated. Through ab initio orbital calculations and by employing Koopmans' theorem, the core‐electron binding energies (CEBEs) were evaluated for a substantial number of possible chemical functionalities positioned on PE‐based model structures. The calculated ΔCEBEs showed to be in reasonable agreement with experimental reference data. The calculated ΔCEBEs were used to develop a material‐specific peak model suitable for the interpretation of merged high‐resolution C 1 s, N 1 s and O 1 s XPS spectra of PE‐based materials. In contrast to conventional peak fitting, the presented approach allowed the distinction of functionality positioning (i.e. centred or end‐chain) and evaluation of the long‐range effects of the chemical functionalities on the PE carbon backbone. Altogether, a more detailed interpretation of the modified UHMWPE surfaces was achieved whilst reducing the need for manual input and personal bias introduced by the spectral analyst.
DNA Origami Nanostructures Elicit Dose‐Dependent Immunogenicity and Are Nontoxic up to High Doses In Vivo
Authors: Lucas Christopher R. , Halley Patrick D. , Chowdury Amjad A. , Harrington Bonnie K. , Beaver Larry , Lapalombella Rosa , Johnson Amy J. , Hertlein Erin K. , Phelps Mitch A. , Byrd John C. , Castro Carlos E. 
Published: May 2022

AbstractDNA origami (DO) nanotechnology enables the construction of precise nanostructures capable of functionalization with small molecule drugs, nucleic acids, and proteins, suggesting a promising platform for biomedical applications. Despite the potential for drug and vaccine delivery, the impact of DO vehicles on immunogenicity in vivo is not well understood. Here, two DO vehicles, a flat triangle and a nanorod, at varying concentrations are evaluated in vitro and with a repeated dosing regimen administered at a high dose in vivo to study early and late immunogenicity. The studies show normal CD11b+ myeloid cell populations preferentially internalize DO in vitro. DO structures distribute well systemically in vivo, elicit a modest pro‐inflammatory immune response that diminishes over time and are nontoxic as shown by weight, histopathology, lack of cytokine storm, and a complete biochemistry panel at the day 10 end point. The results take critical steps to characterize the biological response to DO and suggest that DO vehicles represent a promising platform for drug delivery and vaccine development where immunogenicity should be a key consideration.
Stem Cell Membrane‐Encapsulated Zeolitic Imidazolate Framework‐8: A Targeted Nano‐Platform for Osteogenic Differentiation
Authors: Ren Na , Liang Na , Dong Mengwei , Feng Zhichao , Meng Ling , Sun Chunhui , Wang Aizhu , Yu Xin , Wang Wenhan , Xie Juan , Liu Chao , Liu Hong 
Published: May 2022

AbstractMesenchymal stem cells (MSCs) have been recognized as one of the most promising pharmaceutical multipotent cells, and a key step for their wide application is to safely and efficiently regulate their activities. Various methods have been proposed to regulate the directional differentiation of MSCs during tissue regeneration, such as nanoparticles and metal ions. Herein, nanoscale zeolitic imidazolate framework‐8 (ZIF‐8), a Zn‐based metal–organic framework, is modified to direct MSCs toward an osteoblast lineage. Specifically, ZIF‐8 nanoparticles are encapsulated using stem cell membranes (SCMs) to mimic natural molecules and improve the biocompatibility and targeted ability toward MSCs. SCM/ZIF‐8 nanoparticles adjust the sustained release of Zn2+, and promote their specific internalization toward MSCs. The internalized SCM/ZIF‐8 nanoparticles show excellent biocompatibility, and increase MSCs’ osteogenic potentials. Moreover, RNA‐sequencing results elucidate that the activated cyclic adenosine 3,5‐monophosphate (cAMP)‐PKA‐CREB signaling pathway can be dominant in accelerating osteogenic differentiation. In vivo, SCM/ZIF‐8 nanoparticles greatly promote the formation of new bone tissue in the femoral bone defect detected by 3D micro‐CT, hematoxylin and eosin staining, and Masson staining after 4 weeks. Overall, the SCM‐derived ZIF‐8 nanostructures achieve the superior targeting ability, biocompatibility, and enhanced osteogenesis, providing a constructive design for tissue repair.
Deviation from a state of perfect uniformity: An indicator of structural complexity in projects
Authors: Zarghami Seyed Ashkan 
Published: May 2022

AbstractThe complexity of projects arising from interconnectedness between activities is believed to be one of the most significant challenges for managing projects. Although the literature has long appreciated the significance of measuring complexity, research on this topic is weakened by the lack of a method that accounts for a diverse set of structural characteristics of project networks. To evade this pitfall, this paper introduces the concept of perfect uniformity and develops a comprehensive measure of structural complexity in projects. The proposed method is validated by applying it in two real‐life projects. The validation results confirm that project complexity is positively associated with a higher level of deviation from a state of perfect uniformity. This research is among few studies that draw on the concept of emergence and point out the importance of a system‐level approach in project management to analyse the interdependency between multiple interconnected activities.
Experimental investigation of fire effects under axial compression on ductility and stiffness of (SIFCON) columns
Authors: Kadhum Mohammed M. , Hashim Ali M. , Khamees Shahad S. , Akhaveissy Amir H. , Ali Abduljabar H. 
Published: May 2022

AbstractThis article is an experimental study of the efficiency after fire exposure of slurry infiltrated fiber concrete (SIFCON) columns. The aim of this paper is to present a comprehensive study of the fire effect on the stiffness, ductility, and energy absorption capacity of axially loaded SIFCON columns and to inspect the effect of hollow ratio and cross section shape on the energy dissipation ability, ductility, and stiffness features of the post‐fire behavior of these columns. Hybrid fibers were used to cast SIFCON columns with 6% fiber ratio (3% hooked end fiber + 3% straight micro fiber). The results showed that the cube compressive strength decreased by 25.1% and 53% when exposed to fire at a temperatures of 600 and 900°C, respectively. The results obtained revealed that after exposure to fire, the indices values of displacement ductility are not strongly impaired and it has been shown that the assessment of the energy dissipation ability is more relevant in this situation. Whereafter fire exposure at 600°C, the SIFCON columns lost about 11%–31% of the energy absorption capacity and about 39%–57% after fire exposure at 900°C. In comparison, after fire exposure, the secant and initial stiffness greatly degraded and the reduction percentages became higher with a rise in fire temperature from 600 to 900°C.
A Dime Rolls Up to a Domino: Using Mnemonic Stories to Orient b and d
Authors: Murray Bruce , Wang Chi‐hsuan , Murray Geralyn , Sanders Mary , McHugh Ashley 
Published: May 2022

AbstractIn a quasi‐experimental study, kindergarten teachers taught children mnemonic stories to orient the confusable letters b and d. In the first week's stories, intervention teachers introduced the left‐to‐right sequence of features for these letters with “the bat hits the ball” and “a dime rolls up to a domino.” The second week's stories dramatized how to print these letters efficiently. Comparison teachers taught their normal literacy curriculum. Intervention students significantly outperformed students in the comparison group in letter naming and letter printing. They gained accuracy in letter recognition that transferred to selecting the correct word from similar b and d words and in reading simple words with b and d. These findings support a new path to establish reliable recognition of letters that vary only in orientation.
Diagnostic test accuracy of magnetic resonance imaging and pelvic floor ultrasound for diagnosis of levator ani muscle avulsion
Authors: van Gruting I. M. A. , Stankiewicz A. , van Delft K. W. M. , Doumouchtsis S. K. , Inthout J. , Sultan A. H. , Thakar R. 
Published: May 2022

ABSTRACTObjectiveTo estimate the diagnostic test accuracy of magnetic resonance imaging (MRI) and pelvic floor ultrasound for levator ani muscle (LAM) avulsion in a general parous population, with view to establishing if ultrasound could substitute for MRI to diagnose LAM avulsion.MethodsThis was a cross‐sectional study of 135 women 4 years after their first delivery. Signs and symptoms of pelvic floor dysfunction were assessed using validated methods. All women underwent four‐dimensional transperineal ultrasound (TPUS), three‐dimensional endovaginal ultrasound (EVUS) and MRI. Images were acquired at rest, on pelvic floor muscle contraction (PFMC) and on maximum Valsalva maneuver, and analyzed by two blinded observers. Predefined cut‐off values were used to diagnose LAM avulsion. In the absence of a reference standard, latent class analysis (LCA) was used to establish diagnostic test characteristics for LAM avulsion as the primary outcome measure. Secondary outcomes were kappa (κ) agreement between imaging techniques, intraclass correlation coefficients (ICC) for hiatal measurements at rest, on PFMC and on maximum Valsalva maneuver, and the association of LAM avulsion with signs and symptoms of pelvic floor dysfunction.ResultsThe prevalence of LAM avulsion was 23.0% for MRI, 11.1% for TPUS and 17.8% for EVUS. The prevalence of LAM avulsion using LCA was 15.7%. The sensitivity for LAM avulsion of TPUS (71% (95% CI, 50–90%)) and EVUS (91% (95% CI, 74–100%)) was lower than that of MRI (100% (95% CI, 84–100%)). The specificity of TPUS (100% (95% CI, 97–100%)) and EVUS (95% (95% CI, 91–99%)) was higher than that of MRI (91% (95% CI, 85–97%)). MRI and EVUS had high predictive values for the assessment of major LAM avulsion (positive predictive value (PPV), 95% and negative predictive value (NPV), 100%; PPV, 100% and NPV, 98%, respectively), while TPUS had high predictive values for minor LAM avulsion (PPV, 100% and NPV, 95%). Major LAM avulsion on MRI and EVUS was associated with anterior vaginal wall prolapse, which was not found for TPUS. The agreement in the diagnosis of LAM avulsion (κ, 0.69) and hiatal measurements (ICC, 0.60–0.81) was highest between MRI and EVUS.ConclusionsPelvic floor ultrasound can be implemented as a triage test to assess parous women for LAM avulsion because of its high specificity. Ultrasound cannot substitute for MRI because of its lower sensitivity. The predictive ability of ultrasound is moderate for the presence, and very good for the absence, of LAM avulsion. A positive test should be confirmed by a different observer or imaging technique. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.