bluuebunny/crossref_metadata_2025_split huggingface dataset:
From concept to action: a united, holistic and One Health approach to respond to the climate change crisis
Authors: Zhang Renhe , Tang Xu , Liu Jian , Visbeck Martin , Guo Huadong , Murray Virginia , Mcgillycuddy Catherine , Ke Bing , Kalonji Gretchen , Zhai Panmao , Shi Xiaoming , Lu Jiahai , Zhou Xiaonong , Kan Haidong , Han Qunli , Ye Qian , Luo Yong , Chen Jianmin , Cai Wenjia , Ouyang Huiling , Djalante Riyanti , Baklanov Alexander , Ren Lu , Brasseur Guy , Gao George Fu , Zhou Lei 
Published: February 2022

AbstractIt is unequivocal that human influence has warmed the planet, which is seriously affecting the planetary health including human health. Adapting climate change should not only be a slogan, but requires a united, holistic action and a paradigm shift from crisis response to an ambitious and integrated approach immediately. Recognizing the urgent needs to tackle the risk connection between climate change and One Health, the four key messages and recommendations that with the intent to guide further research and to promote international cooperation to achieve a more climate-resilient world are provided.
Graphical Abstract
Using machine learning to explore core risk factors associated with the risk of eating disorders among non-clinical young women in China: A decision-tree classification analysis
Authors: Ren Yaoxiang , Lu Chaoyi , Yang Han , Ma Qianyue , Barnhart Wesley R. , Zhou Jianjun , He Jinbo 
Published: February 2022

Abstract
Background
Many previous studies have investigated the risk factors associated with eating disorders (EDs) from the perspective of emotion regulation (ER). However, limited research has investigated interactions between co-existing risk factors for EDs, especially in China where research in EDs is underrepresented.

Methods
This study examined core risk factors related to maladaptive eating behaviors and ER, and how their interactions affect the detection of EDs. Using machine learning, a decision tree model was constructed on a data set of 830 non-clinical Chinese young women with an average age of 18.91 years (SD = 0.95). The total data set was split into training and testing data sets with a ratio of 70 to 30%.

Results
Body image inflexibility was identified as the major classifier for women at high risk of EDs. Furthermore, interactions between body image inflexibility, psychological distress, and body dissatisfaction were important in detecting women at high risk of EDs. Overall, the model classifying women at high-risk for EDs had a sensitivity of 0.88 and a specificity of 0.85 when applied to the testing data set.

Conclusions
Body image inflexibility, psychological distress, and body dissatisfaction were identified as the major classifiers for young women in China at high risk of EDs. Researchers and practitioners may consider these findings in the screening, prevention, and treatment of EDs among young women in China.
Immune cell gene expression signatures in diffuse glioma are associated with IDH mutation status, patient outcome and malignant cell state, and highlight the importance of specific cell subsets in glioma biology
Authors: Mehani Bharati , Asanigari Saleembhasha , Chung Hye-Jung , Dazelle Karen , Singh Arashdeep , Hannenhalli Sridhar , Aldape Kenneth 
Published: February 2022

AbstractThe tumor micro-environment (TME) plays an important role in various cancers, including gliomas. We estimated immune cell type-specific gene expression profiles in 3 large clinically annotated glioma datasets using CIBERSORTx and LM22/LM10 blood-based immune signatures and found that the proportions and estimated gene expression patterns of specific immune cells significantly varied according to IDH mutation status. When IDH-WT and IDH-MUT tumors were considered separately, cluster-of-cluster analyses of immune cell gene expression identified groups with distinct survival outcomes. We confirmed and extended these findings by applying a signature matrix derived from single-cell RNA-sequencing data derived from 19 glioma tumor samples to the bulk profiling data, validating findings from the LM22/LM10 results. To link immune cell signatures with outcomes in checkpoint therapy, we then showed a significant association of monocytic lineage cell gene expression clusters with patient survival and with mesenchymal gene expression scores. Integrating immune cell-based gene expression with previously described malignant cell states in glioma demonstrated that macrophage M0 abundance significantly correlated with mesenchymal state in IDH-WT gliomas, with evidence of a previously implicated role of the Oncostatin-M receptor and macrophages in the mesenchymal state. Among IDH-WT tumors that were enriched for the mesenchymal cell state, the estimated M0 macrophage expression signature coordinately also trended to a mesenchymal signature. We also examined IDH-MUT tumors stratified by 1p/19q status, showing that a mesenchymal gene expression signature the M0 macrophage fraction was enriched in IDH-MUT, non-codeleted tumors. Overall, these results highlight the biological and clinical significance of the immune cell environment related to IDH mutation status, patient prognosis and the mesenchymal state in diffuse gliomas.
Task-agnostic representation learning of multimodal twitter data for downstream applications
Authors: Rivas Ryan , Paul Sudipta , Hristidis Vagelis , Papalexakis Evangelos E. , Roy-Chowdhury Amit K. 
Published: February 2022

AbstractTwitter is a frequent target for machine learning research and applications. Many problems, such as sentiment analysis, image tagging, and location prediction have been studied on Twitter data. Much of the prior work that addresses these problems within the context of Twitter focuses on a subset of the types of data available, e.g. only text, or text and image. However, a tweet can have several additional components, such as the location and the author, that can also provide useful information for machine learning tasks. In this work, we explore the problem of jointly modeling several tweet components in a common embedding space via task-agnostic representation learning, which can then be used to tackle various machine learning applications. To address this problem, we propose a deep neural network framework that combines text, image, and graph representations to learn joint embeddings for 5 tweet components: body, hashtags, images, user, and location. In our experiments, we use a large dataset of tweets to learn a joint embedding model and use it in multiple tasks to evaluate its performance vs. state-of-the-art baselines specific to each task. Our results show that our proposed generic method has similar or superior performance to specialized application-specific approaches, including accuracy of 52.43% vs. 48.88% for location prediction and recall of up to 15.93% vs. 12.12% for hashtag recommendation.
Clinical Models to Define Response and Survival With Anti–PD-1 Antibodies Alone or Combined With Ipilimumab in Metastatic Melanoma
Authors: Pires da Silva Inês , Ahmed Tasnia , McQuade Jennifer L. , Nebhan Caroline A. , Park John J. , Versluis Judith M. , Serra-Bellver Patricio , Khan Yasir , Slattery Tim , Oberoi Honey K. , Ugurel Selma , Haydu Lauren E. , Herbst Rudolf , Utikal Jochen , Pföhler Claudia , Terheyden Patrick , Weichenthal Michael , Gutzmer Ralf , Mohr Peter , Rai Rajat , Smith Jessica L. , Scolyer Richard A. , Arance Ana M. , Pickering Lisa , Larkin James , Lorigan Paul , Blank Christian U. , Schadendorf Dirk , Davies Michael A. , Carlino Matteo S. , Johnson Douglas B. , Long Georgina V. , Lo Serigne N. , Menzies Alexander M. 
Published: February 2022

PURPOSE Currently, there are no robust biomarkers that predict immunotherapy outcomes in metastatic melanoma. We sought to build multivariable predictive models for response and survival to anti-programmed cell death protein 1 (anti–PD-1) monotherapy or in combination with anticytotoxic T-cell lymphocyte-4 (ipilimumab [IPI]; anti–PD-1 ± IPI) by including routine clinical data available at the point of treatment initiation. METHODS One thousand six hundred forty-four patients with metastatic melanoma treated with anti–PD-1 ± IPI at 16 centers from Australia, the United States, and Europe were included. Demographics, disease characteristics, and baseline blood parameters were analyzed. The end points of this study were objective response rate (ORR), progression-free survival (PFS), and overall survival (OS). The final predictive models for ORR, PFS, and OS were determined through penalized regression methodology (least absolute shrinkage and selection operator method) to select the most significant predictors for all three outcomes (discovery cohort, N = 633). Each model was validated internally and externally in two independent cohorts (validation-1 [N = 419] and validation-2 [N = 592]) and nomograms were created. RESULTS The final model for predicting ORR (area under the curve [AUC] = 0.71) in immunotherapy-treated patients included the following clinical parameters: Eastern Cooperative Oncology Group Performance Status, presence/absence of liver and lung metastases, serum lactate dehydrogenase, blood neutrophil-lymphocyte ratio, therapy (monotherapy/combination), and line of treatment. The final predictive models for PFS (AUC = 0.68) and OS (AUC = 0.77) included the same variables as those in the ORR model (except for presence/absence of lung metastases), and included presence/absence of brain metastases and blood hemoglobin. Nomogram calculators were developed from the clinical models to predict outcomes for patients with metastatic melanoma treated with anti–PD-1 ± IPI. CONCLUSION Newly developed combinations of routinely collected baseline clinical factors predict the response and survival outcomes of patients with metastatic melanoma treated with immunotherapy and may serve as valuable tools for clinical decision making.
The Rendezvous of Victory: Translations of Bandung Humanism
Authors: Spanos Adam 
Published: February 2022

AbstractThis article tracks the engagement of several twentieth-century writers with a line from Aimé Césaire’s Cahier d’un retour au pays natal (Journal of a Homecoming): “et il est place pour tous au rendez-vous de la conquête” (and there is room for all at the appointed place of conquest; translated by C. L. R. James as “there is a place for all at the rendezvous of victory”). This line came to define an ethics and an aesthetics for the cultural movement that ensued in the wake of the Bandung conference, which brought together heads of state from the third world in pursuit of national independence. In the critical commentaries and artistic engagements with Césaire’s work by James, Frantz Fanon, Nadine Gordimer, and Edward Said, a form of internationalism emerged that was sustained by a common investment in this poetic image. These writers weren’t bound by an identity of interest, however, but rather by the displacements to which they subjected Césaire’s poem through their linguistic, generic, affective, and semantic translations. The essay concludes that Bandung humanism supposed a contingent and revisable understanding of the human and promoted an aesthetic of reworking rather than timeless forms.
Pasolini in/and Catalonia: Translation, Minority Languages, and Internationalism
Authors: White Jerry 
Published: February 2022

Abstract
This article posits that Pier Paolo Pasolini’s long engagement with Catalonia offers important insights into his practice as a poet, filmmaker, and thinker about language, as well as explaining the nature of his influence on other European cinemas. The first part of the article focusses on the special issue “Fiore di poeti catalani” of Quaderno romanzo alongside Pasolini’s poetry in and advocacy for the Friulan language. The second part of the article focusses on Joaquín (Joaquim) Jordà’s translation of Pasolini, published as Cine de poesía contra cine de prosa, alongside the emergence of the Barcelona school of filmmakers, of which Jordà was a part. Overall, the article argues that although there was clearly an Italian influence on Catalan cinema of the 1960s and 1970s, throughout the long course of his career there was a distinctly Catalan quality to Pasolini’s thought.
“Can the Concept of God Exist in a Perfectly Logical Language?” Baraka, Wittgenstein, and the Hermeneutics of Counter-Enlightenment
Authors: Lewis Alexander 
Published: February 2022

AbstractThis article looks at the influence of Ludwig Wittgenstein’s early philosophy of language on the Black Arts Movement. Amiri Baraka’s essay / prose poem “Expressive Language” ends with a quotation from Wittgenstein: “Can the concept of God exist in a perfectly logical language?” The problem is that Wittgenstein never wrote this. In tracking the meaning of Baraka’s pseudo ascription, this essay situates Baraka’s early work in the context of midcentury philosophy of language and the linguistic turn. It argues that Baraka’s extensive engagement with the form and thought of Wittgenstein’s Tractatus Logico-Philosophicus is crucially important in Baraka’s narration of his conversion from Beat bohemianism to Black nationalism. Baraka’s argument with Wittgenstein anticipates the concerns of a debate that occurred several years later between Hans Gadamer and Jürgen Habermas. Reading “Expressive Language” and Baraka’s poetry and autobiographical writing alongside the exchanges of the Gadamer-Habermas debate, the essay argues that Baraka’s writings challenge the identification of critique with progressive politics that informs the work of Habermas and Paul Gilroy.
A zebrafish reporter line reveals immune and neuronal expression of endogenous retrovirus
Authors: Rutherford Holly A. , Clarke Amy , Chambers Emily V. , Petts Jessica J. , Carson Euan G. , Isles Hannah M. , Duque-Jaramillo Alejandra , Renshaw Stephen A. , Levraud Jean-Pierre , Hamilton Noémie 
Published: February 2022

ABSTRACTEndogenous retroviruses (ERVs) are fossils left in our genome from retrovirus infections of the past. Their sequences are part of every vertebrate genome and their random integrations are thought to have contributed to evolution. Although ERVs are mainly silenced by the host genome, they have been found to be activated in multiple disease states, such as auto-inflammatory disorders and neurological diseases. However, the numerous copies in mammalian genomes and the lack of tools to study them make defining their role in health and diseases challenging. In this study, we identified eight copies of the zebrafish endogenous retrovirus zferv. We created and characterised the first in vivo ERV reporter line in any species. Using a combination of live imaging, flow cytometry and single-cell RNA sequencing, we mapped zferv expression to early T cells and neurons. Thus, this new tool identified tissues expressing ERV in zebrafish, highlighting a potential role of ERV during brain development and strengthening the hypothesis that ERV play a role in immunity and neurological diseases. This transgenic line is therefore a suitable tool to study the function of ERV in health and diseases.
APLICAÇÃO DE TESTES E USO DOS CONCEITOS DE GAMEFICATION NA FERRAMENTA BEM
Authors: Santos Ana Jaize de Oliveira 
Published: February 2022

Nos dias de hoje, professores não são apenas aqueles que transferem conhecimento, mas, principalmente, aqueles que auxiliam o aprendiz no processo de construção do conhecimento. Para isto, é fundamental ser um profissional que domine não somente o conteúdo da sua área específica, mas, igualmente, metodologias e didáticas eficazes na missão de organizar o acesso dos estudantes às informações e construção de conhecimentos.O procedimento educacional do sujeito sempre foi um grande desafio na vida dos professores. Definir a melhor maneira e um método eficaz para expor um conteúdo exige esforços para que a formação do conhecimento ocorra de forma satisfatória. Tendo como exemplo um indivíduo com deficiência visual (DV), que precisa de acompanhamento educacional e social mais próximo, para conseguir desenvolver, com êxito, suas habilidades e obter, com isso, uma condição de vida mais condizente com a realidade que necessita e que deseja, é ainda mais importante refletir sobre como incluir este cidadão e que recursos oferecê-los. Nesse contexto, é indispensável que o professor reveja e amplie, constantemente, seus conhecimentos, visando à atualização da maneira e do método de como lidar com essas pessoas.Para auxiliar os professores nesse campo, surgem os Objetos de Aprendizagem (OA), que se apresentam como uma proposta de ensino-aprendizagem auxiliada pelas TIC e que tem a finalidade de estimular a capacidade e o desenvolvimento das habilidades do educando, por meio da utilização de diversas mídias como: jogos (eletrônicos ou não), vídeos, simulações, etc. O principal agente dos OA e o mais responsável pela sua utilização e difusão é o computador, funcionando como instrumento lúdico e de auxílio no processo de ensino-aprendizagem dos educandos (CUNHA, 2007). Araújo (1997) afirma que uma proposta pedagógica séria e intermediada por jogos computacionais pode contribuir não só para o processo de inclusão dos DV, como também para aquisição de conhecimento.A partir desse contexto, foi desenvolvido o jogo BEM (Blinds, Education and Mathematics) por DANTAS, PINTO e SENA (2013), em seu trabalho de conclusão de curso. Rafael Macêdo, bolsista FAPESB 2014/2015 e CNPQ 2015/2016, vem dando continuidade a esse trabalho, no sentido de fazer correções de erros e falhas existentes, além de adicionar novas funcionalidades, como reconhecimento de voz.Nesse sentido, este trabalho teve como principal objetivo o desenvolvimento de testes de funcionalidades do jogo BEM, durante a fase de desenvolvimento, visando garantir a qualidade do produto final, assim como testes de usabilidade e navegabilidade (CARVALHO, 1994; PEREIRA, 2002). Além disso, com o resultado dos testes e com o auxílio de técnicas específicas, foram propostas e realizadas alterações nas interfaces (vocal e visual) do BEM, visando, desta forma, uma nova dinâmica para o jogo.
El exilio como lugar de enunciación en la obra de Sarrionandia: silencio y búsqueda de la escritura contrapuntística
Authors: Eizagirre-Telleria Nerea 
Published: February 2022

El presente artículo analiza la conceptualización paradójica del exilio según el paradigma de Said y expande dicho análisis con las reflexiones de Joseba Sarrionandia. En la obra de Sarrionandia se percibe un viaje intelectual hasta llegar a la posición ontológica del exilio. El silencio y la búsqueda de una nueva lengua son dos momentos de tránsito en el itinerario sarrionandiano hasta armar una escritura capaz de expresar la perspectiva de marginalidad y disidencia que supone el exilio como paradigma. El final del artículo se enfoca en el erudito ensayo Moroak gara behelaino artean? para comprender a grandes rasgos la escritura contrapuntística de Sarrionandia.
CREAPP K6-12: Tool to evaluate the creative potential of app oriented to the design of personal digital storytelling
Authors: Del Moral Pérez Maria Eshter , Bellver Moreno Maria Carmen , Guzmán Duque Alba Patricia 
Published: February 2022

An instrument is presented that allows primary school teachers to evaluate the potentiality to develop creativity that have playful online app K6-12 focused on the development of digital storytelling (DST), so they can select those that can be used in the classroom for that purpose. The instrument validated consists of 48 indicators associated with the six dimensions of the creativity: flexibility, originality, fluency, problem solving, elaboration of products and co-edition and dissemination. It was designed based on the opinions of experts in creativity and Information and Communication Technologies of the didactic field, theory of education and methodology; also with the assessments and clarifications made by a focus group of final users. Subsequently, three different coders applied the final instrument to evaluate an app sample (N=20) according to the requirements, to validate it using Cohen's Kappa statistic, as an alternative consistent to measure the concordance between the judgments issued by the three coders, obtaining a k=0.897, that is, a high concordance, and with it, reaffirm the validity of the instrument to measure the potential of these app to promote creativity of school children.
Primary Educational Strategies in Times of Digital Curriculum
Authors: Gallardo Fernández Isabel María , Monsalve Lorente Laura , Aguasanta Regalado Miriam Elizabeth 
Published: February 2022

Our contribution is based on the most noteworthy results of a research project focusing on teaching strategies at a time when the contents of the primary education curriculum are becoming digital. The expansion of the digital content industry is forcing a paradigm shift. In this paper we analyse the strategies implemented by teachers of the fifth and sixth year of primary school in relation with the digitisation of curricular content. With this aim, we planned our research following ethnographic methodology, analysing a period of two years of a case study. The main data collection tools we used are the analysis of the centre’s documents and website, semi-structured interviews with different participants, and direct observation of fifth and sixth year primary education classrooms. We can infer from the analysis that technology facilitates processes of inclusion in the centre, enhancing collaborative and cooperative work. Furthermore, the use of digital devices promotes attention to diversity. The implementation of digital technologies in schools implies redefining teaching practices and teaching-learning processes.The results show that the addition of digital materials is a step forward in the centre’s attention to diversity, improving accessibility and overcoming the digital gap thanks to schools’ access to technological resources.
Performance analysis of a compact auto-phoropter for accessible refractive assessment of the human eye
Authors: Akhoundi Farhad , Ozgur Erol , Draper Craig , Voorakanam Ram , Wycoff Jaclyn , Reetz Daniel , Blanche Pierre-Alexandre , LaComb Lloyd , Peyman Gholam , Schwiegerling Jim , Peyghambarian N. 
Published: February 2022

We present the performance analysis and specifications of a portable auto-phoropter system that can be employed for fast refractive assessment of a large population. A customized Shack–Hartmann wavefront sensor is developed to accurately measure the defocus and astigmatism of the eye within

±
10

D

and

±
6

D

, respectively. Three fluidic lenses are designed to correct the vision in real time. A digital Snellen chart is integrated into the system to validate the accuracy of the measurement and the correction by means of achieving 20/20 vision. The refractive error of eight subjects (16 eyes) has been measured objectively (without patient’s feedback) using the proposed system and the results are compared with their clinical prescription through the Bland–Altman method. It is shown that the auto-phoropter takes less than 8 s to measure and correct the eye refractive error with an accuracy of

±

0.25

D

.