bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression and prognosis analyses of PEA3 subfamily in head and neck squamous cell carcinoma via integrated bioinformatics
Authors: wei mei , wang wei , ni guangjian 
Published: January 2022

Abstract
Backgroud:

The PEA3 subfamily belongs to the first category of the ETS family, and it consists of three family members, namely, ETV1, ETV4, and ETV5. These members were implicated in the progression of many cancers. But their prognostic roles in head and neck squamous cell carcinoma (HNSCC) remain to be characterized.
Methods

Data from multiple open databases were used to analyze the expression, regulation, mutations, immune infiltration, and functional networks of the PEA3 subfamily in patients with HNSCC.
Results

The results demonstrated that these patients showed downregulated ETV1 and upregulated ETV4/5 compared with healthy subjects. Furthermore, high expression of ETV4/5 and low expression of ETV1 were linked to the shortened overall survival in patients with HNSCC. The immune infiltration in B cells stimulated the prognosis, and it may have a prognostic medical significance linked to the PEA3 subfamily in HNSCC. These results showed that data mining efficiently revealed the expression of the PEA3 subfamily in HNSCC, but this study requires further large-scale genomic and basic research.
Conclusions

This study provided new insight into the prognostic roles of PEA3 subfamily in HNSCC with potential mechanistic values.
Multi-step-ahead prediction of river flow using NARX neural networks and deep learning LSTM
Authors: Hayder Gasim , Iwan Solihin Mahmud , Najwa M. R. N. 
Published: January 2022

Abstract
Kelantan river (Sungai Kelantan in Malaysia) basin is one of the essential catchments as it has a history of flood events. Numerous studies have been conducted in river basin modelling for the prediction of flow and mitigation of flooding events as well as water resource management. Therefore, having multi-step-ahead forecasting for river flow (RF) is of important research interest in this regard. This study presents four different approaches for multi-step-ahead forecasting for the Kelantan RF, using NARX (nonlinear autoregressive with exogenous inputs) neural networks and deep learning recurrent neural networks called LSTM (long short-term memory). The dataset used was obtained in monthly record for 29 years between January 1988 and December 2016. The results show that two recursive methods using NARX and LSTM are able to do multi-step-ahead forecasting on 52 series of test datasets with NSE (Nash–Sutcliffe efficiency coefficient) values of 0.44 and 0.59 for NARX and LSTM, respectively. For few-step-ahead forecasting, LSTM with direct sequence-to-sequence produces promising results with a good NSE value of 0.75 (in case of two-step-ahead forecasting). However, it needs a larger data size to have better performance in longer-step-ahead forecasting. Compared with other studies, the data used in this study is much smaller.
Revising green roof design methods with downscaling model of rainfall time series
Authors: Pons V. , Muthanna T. M. , Sivertsen E. , Bertrand-Krajewski J.-L. 
Published: January 2022

Abstract
Historically, green infrastructure for stormwater management has been event-based designed. This study aims to realign the green infrastructure design strategies with principles for robust decision making, through the example of green roofs design with the variational method and exemplified using the Norwegian context of the 3-step approach (3SA) for stormwater management. The 3SA consists of planning solutions to handle day-to-day rain at site scale through infiltration (step 1) and detention (step 2), and extreme events with safe floodways (step 3). An innovative framework based on downscaling of rainfall timeseries is suggested as follows: (i) long duration continuous simulation for retention variation and day-to-day discharge, corresponding to step 1 in the 3SA; (ii) intensive sampling of local extreme events to estimate reliability and robustness of solutions, corresponding to steps 2 and 3 in the 3SA. Comparing the traditional variational method to Highly-Informed-Design-Evaluation-Strategy (HIDES), it was found that the variational method possibly leads to incorrect decisions while the suggested novel approach was found to give more informed and reliable results by suggesting a design based on both operating mode and failure mode. It allows to embed solutions within the urban water system by facilitating the link between the steps of the 3SA. Such a framework was found to be data-wise applicable in the Norwegian context.
effect of cash holding, profitability, and financial leverage on firm value with earnings management as moderating variables in manufacturing companies listed on the Indonesia stock exchange
Authors: Irawan Doddy , Widiyanti Marlina , Fuadah Luk Luk , Adam Mohamad 
Published: January 2022

This study aims to determine the effect of cash holding, profitability (ROA), financial leverage (DER) on firm value (PBV) with earnings management as a moderating variable in manufacturing companies listed on the Indonesia Stock Exchange. The sample of this research is 24 companies in the manufacturing sector with a research period from 2015-2020. The data analysis technique used in this study is moderated regression analysis (MRA). The results showed that cash holding and earnings management did not affect firm value (PBV). Profitability, as measured by return on assets (ROA) and financial leverage as measured by debt to equity ratio (DER), has a significant positive effect on firm value (PBV). The results also conclude that earnings management does not have a moderating role in the effect of cash holding, profitability (ROA), financial leverage (DER) on firm value (PBV).
Ansiedad y nivel de conocimiento en cuidados paliativos en estudiantes de Guerrero
Authors: Peña-Marcial Elvia , Diaz-Marcelo Jorge Sait , Reyna -Avila Leticia , Pérez-Cabañas Rodrigo , Bernal-Mendoza Lorena Inés 
Published: January 2022

Objetivo: Identificar el nivel de conocimiento en cuidados paliativos y ansiedad ante la muerte en estudiantes de las escuelas de enfermería, de la Universidad Autónoma de Guerrero. Materiales y métodos: estudio mixto con diseño transversal comparativo y analítico; y fenomenológico mediante la narrativa testimonial. Se encuestaron 380 estudiantes de cuarto año de licenciatura, a 18 de se les realizó una entrevista a profundidad (25 a 40 minutos). Resultados: El 78.7% de los estudiantes tiene un nivel de conocimientos en cuidados paliativos, malo. Según la escala de ansiedad y miedo a la muerte de Collett-Lester, el 66.3% perciben un nivel muy ansioso/a, de los cuatro panoramas de muerte se encontró que, a la propia muerte 55.3% moderadamente ansioso/a; al propio proceso de morir 57.1% muy ansioso/a; a la muerte de otros 75.5% muy ansioso/a y al proceso de morir de otros 60% muy ansioso/a. Ante el proceso de muerte, describieron sentimientos de tristeza, ansiedad, vacío profundo, desesperación, temor, frustración, enojo, actitud de autocontrol, aceptación. Las intervenciones que emplearían, en el paciente hospitalizado etapa terminal y con los familiares serían técnicas y procedimientos para prevenir otras patologías y el alivio del dolor. Conclusión: los estudiantes tienen un nivel de conocimiento malo en cuidados paliativos, porque el plan de estudios no integra alguna unidad de aprendizaje específica para este cuidado. El nivel de ansiedad ante la muerte tuvo una representación muy alta, los estudiantes se perciben muy ansiosos/as ante los procesos de muerte.
Divertículos duodenales periampulares y el fallo técnico-terapéutico durante colangiopancreatografía retrógrada endoscópica (CPRE).
Authors: Zavaleta Carlos , Quesada Fernando , Aparicio Blanco Brandon Steven , Pedraza Ciro Mauricio , Mendoza Zuchini Andrés , Cabrera Luis Felipe 
Published: January 2022

Introducción y objetivos: Los divertículos duodenales periampulares (DDP), son infrecuentes y su hallazgo es incidental. Además, se clasifican en tres tipos según Boix por la cercanía a la ampolla mayor. El objetivo de este estudio fue realizar una descripción de nuestra experiencia con esta anomalía anatómica y demostrar cómo esto afecta la tasa de éxito técnica y terapéutica del procedimiento.
Material y métodos: Se realizó un estudio de corte transversal, con recolección de datos de forma retrospectiva. En un periodo de 5 años de pacientes con divertículos periampulares duodenales. Se evaluó el fracaso terapéutico, complicaciones y dificultad de canulación de la vía biliar.
Resultados: Un total de 214 pacientes fueron evaluados, con una relación mujer hombre de 2,15 : 1. La distribución de los sujetos por tipo de DDP fue: Tipo I (29.9%), II (51.9%) y III (18.2%). La indicación más frecuente de CPRE fueron los cálculos del conducto biliar común en un 53,3%. El DDP tipo I presentó mayor dificultad de canulación (11.6%) y falla terapéutica (28.12%).
Conclusión: La presencia de DDP durante CPRE se asocia a mayor falla técnica (falla en la canulación) y falla terapéutica (persistencia de la obstrucción biliar). Además, está aumenta considerablemente cuando se trata de una papila intradiverticular Tipo I de la clasificación según Boix. Por lo cual sugerimos que los procedimientos endoscópicos biliares en estas condiciones sean realizados por endoscopistas con gran experiencia con el fin de minimizar la probabilidad de falla técnica, terapéutica y las complicaciones asociadas.
Effects of Data Visualizations on Jurors' Judgments
Authors: Christensen Travis , Rose Anna M. , Rose Jacob M. , Sanderson Kerri-Ann 
Published: January 2022

ABSTRACT
We investigate effects of audit evidence in the form of Big Data visualizations on jurors' decisions. Using an experiment with mock juror participants (n = 582), the study examines how visualization design features and audit evidence reliability affect jurors' negligence assessments. We find evidence for interactive effects of visualization design and evidence reliability where mock jurors make higher negligence likelihood judgments when audit evidence reliability is higher, and visualizations are more vivid. Mediation results indicate that the combination of more vivid visualizations and more reliable audit evidence produces stronger emotional responses related to the auditor defendant; these negative emotional responses increase the likelihood of finding the auditor to be negligent. Overall, we find that data visualization techniques that can improve audit quality may expose auditors to increased litigation risk. Our study informs academics, auditors, and regulators about the potential effects of audit evidence visualization choices on lay evaluators' judgments.
Evaluation of relapse with thermoplastic retainers equipped with microsensors
Authors: İshakoğlu Sait , Çokakoğlu Serpil 
Published: January 2022

ABSTRACT

Objectives
To examine relapse with thermoplastic retainers equipped with microsensors 1 year after treatment.

Materials and Methods
A total of 42 patients (29 females, 13 males) treated with four premolar extractions were included in this study. Thermoplastic appliances equipped with TheraMon microsensors (Handelsagentur Gschladt, Hargelsberg, Austria) were used to assess daily wear time (DWT), and the patients were monitored at 2-month intervals for a period of 12 months. At the end of the follow-up, the following two groups were formed based on the mean DWT: short wear time (SWT; &lt;9 h/d) and long wear time (LWT; ≥9 h/d). Digital models were constructed before treatment (T0), at debonding (T1), and 6 months (T2) and 12 months (T3) after debonding. Little's Irregularity Index (LII) and the intercanine and intermolar widths, arch lengths, overjet, and overbite were calculated based on the digital models. Data were analyzed statistically.

Results
Irregularity and overjet increased, whereas transverse measurements and arch lengths decreased with time in both groups. During the retention period, overbite decreased in the SWT group but increased in the LWT group. There were significant differences between groups only in mandibular irregularity. The LII values of the SWT group were significantly higher than those of the LWT group for the T1–T2 and T1–T3 time intervals (P &lt; .05).

Conclusions
A mean DWT less than 9 hours/day was inadequate for controlling irregularity within clinically acceptable limits. A wear time of at least 9 h/d is recommended for the maintenance of mandibular anterior alignment.
Impact of Diabetes Duration on Functional and Clinical Status in Older Adults With Type 1 Diabetes
Authors: Munshi Medha , Slyne Christine , Adam Atif , Davis Dai’Quann , Michals Amy , Atakov-Castillo Astrid , Weinger Katie , Toschi Elena 
Published: January 2022

OBJECTIVE
Adults with type 1 diabetes (T1D) are aging successfully. The impact of diabetes duration on clinical and functional status as people age with T1D is not well known.

RESEARCH DESIGN AND METHODS
We performed a cross-sectional study of older adults (age ≥65 years) with T1D.

RESULTS
We evaluated 165 older adults, mean age 70 ± 10 years. After adjustment for age, sex, and A1C, longer duration of T1D, ≥50 years, was associated with a higher likelihood of depression (odds ratio [OR] 2.8; P = 0.008), hypoglycemia unawareness (OR 2.6; P = 0.01), lower scores on 6-Minute Walk Test (OR 0.99; P = 0.01) and the Physical Component Summary (PCS) of Short Form-36 (SF-36) (OR 0.96; P = 0.02), and greater daily medication use (OR 1.1; P = 0.004) compared with those with duration &lt;50 years.

CONCLUSIONS
In older adults with T1D, duration of diabetes impacts clinical and functional status, independent of age and glycemic control, and should be considered in development of management strategies for safety and success.
Analyse organisationnelle et économique de la chaine de valeur du savon produit artisanalement à partir d’huile de Carapa procera DC. au Burkina Faso
Authors: Tiétiambou Fanta Reine Sheirita , Lykke Anne Mette , Dembélé Urbain , Mekki Abdelkader Aït El , Korbéogo Gabin , Ouédraogo Amadé 
Published: January 2022

Description du sujet. Carapa procera DC. est un arbre oléagineux local à fort potentiel socio-économique. Sa promotion peut contribuer à diversifier et augmenter les sources de revenus des communautés locales. Objectifs. Le but de cette étude est d’analyser la chaine de valeur (CV) du savon médical artisanal (SMA) de C. procera et d’évaluer son potentiel pour l’amélioration de l’économie locale. Notre analyse se limite aux dimensions organisationnelle et économique de cette CV, notamment sur la création de valeur ajoutée et sa répartition entre les principaux acteurs qui la composent. Méthode. Un inventaire des produits oléagineux de C. procera dans 29 marchés locaux et des enquêtes auprès de 104 acteurs ont été réalisés principalement dans le Kénédougou et dans d’autres localités de vente des produits au Burkina Faso. Résultats. La CV du SMA implique au moins 283 acteurs réalisant 574 activités relatives à la collecte des graines, leur transformation primaire en huile, la transformation secondaire de l’huile en savon et la commercialisation du savon. Soixante-treize pour cent des acteurs sont membres d’une organisation et 71 % des liens entre les acteurs sont basés sur des contrats. Les marges sont de 0,08 €·kg-1 de graines pour les collecteurs, 1,79 €·l-1 d’huile pour les transformateurs primaires et respectivement 1,42 et 2,22 €·kg-1 de savon pour les transformateurs secondaires et les commerçants. Le revenu et la valeur ajoutée annuels perçus par l’ensemble des acteurs de la CV sont respectivement de 10 573 € et 11 335 €. Le revenu total de la CV est inégalement distribué entre les acteurs, avec 20 % d’entre eux qui en totalisent plus de 70 %. Conclusions. L’essor de la CV du savon de C. procera nécessite une redistribution des revenus pour améliorer les parts des acteurs actuellement défavorisés.
TINDAK TUTUR ILOKUSI TEKS POSTER PERBAIKAN TROTOAR JALAN UTAMA KOTA PONTIANAK: KAJIAN TEORI SEARLE
Authors: Damayanti Wahyu 
Published: January 2022

Communication through posters is representative in conveying information that is included in the types of speech acts. These posters are found along the main road in Pontianak City, Some posters are closely related to the repair of sidewalks for pedestrians. The purpose of this research is to describe the types and forms of illocutionary speech acts of the poster text of the pavement improvement of the main road in Pontianak City based on the study of Searle's theory. Qualitative descriptive research method. The research data is speech acts and road repair posters along the main road in Pontianak city. The researcher found the source of written speec data on posters made by jasa marga in the city of Pontianak. Data collection techniques are documentation and notes. The documentation technique is done by taking notes and taking photos of the posters along the repaired sidewalks. The results showed that illocutionary speech acts in the poster text consisted of five types of illocutionary speech acts, including Assertive, in the form of stating, claiming and suggesting, Directivein the form of recommending, giving messages, ordering, advising and recommending, Expressive, in the form of apologizing, Commissive, in the form of threats, and Declaration, in the form of punishing.
The differences of parasitemia and lungs size in malaria-associated acute respiratory distress syndrome (MA-ARDS) and non-MA-ARDS in mice infected with Plasmodium berghei ANKA
Authors: Fuzianingsih Eka Noviya , Callixte Cyuzuzo , La’lang Marselaonety , Putri Dinda Eka , Arwati Heny , Suwanti Lucia Tri 
Published: January 2022

Malaria-associated acute respiratory distress syndrome (MA-ARDS) is characterized by extensive infiltration of leukocytes, microhemorrhages, vasogenic edema, changes in lung color, and a significant increase in the weight of the lung. This study was aimed to find out the differences in parasitemia and lung size in MA-ARDSand non-MA-ARDSin mice infected with Plasmodium berghei ANKA. Sixteen male BALB/c mice were infected with P. berghei ANKA, and daily parasitemia was observed on Giemsa-stained tail blood smears. Mice were sacrificed when parasitemia reached ±20%. Simultaneously eight uninfected mice were used as negative control (NEG). The statistical analysis was done using Kruskal Wallis, Mann Whitney U tests, and Spearman correlation test. The results showed that there were significant differences in parasitemia (p=0.001), weight (p=0.001), and lung length (p=0.021) between the MA-ARDS and non-MA-ARDS groups. Comparison of NEG and MA-ARDS resulted in a significant difference in lung size (p=0.05). When non-MA-ARDScompared with NEG groups, it showed a significant difference in lung width (p=0.001). However, there was no significant difference in lung weight and length (p>0.05). Spearman correlation test showed that there was a strong correlation between parasitemia with weight (p=0.000), length (p=0.001), and lung width (p=0.017). The findings indicated that parasitemia played a role in the development of MA-ARDS in mice infected with P. berghei ANKA and influenced the size of the lung.
Peranan Anggaran Fleksibel Sebagai Alat Pengendalian Biaya Produksi Pada PT. Focon Interlite Pasuruan Jawa Timur
Authors: Dwi Novika Adinda , Desipradani Gita 
Published: January 2022

ABSTRACT The Role of Flexible Budget as a Production Cost Control Tool at PT. Focon Interlite Pasuruan East Java aims to control production costs by implementing a flexible budget at PT. Focon Interlite Pasuruan, East Java. The data analysis technique used in this research is descriptive qualitative analysis. The research stages are collecting data using interviews and documentation, compiling data by identifying the role of flexible budgets as a means of controlling production costs carried out by PT. Focon Interlite Pasuruan, East Java. Based on the results of the analysis of production costs variance in the preparation of the direct material cost budget, which shows that the allocation has been carried efficiently, Then the variance of direct labor costs has a favorable difference. While the preparation of the factory overhead cost variance is favorable.Keywords: Production Cost, Flexible Budget, Cost Control ABSTRAK Peranan Anggaran Fleksibel Sebagai Alat Pengendalian Biaya Produksi Pada PT.Focon Interlite Pasuruan Jawa Timur bertujuan untuk mengendalikan biaya produksi dengan menerapkan anggaran fleksibel pada PT. Focon Interlite Pasuruan Jawa Timur. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis deskriptif kualitatif. Tahapan penelitian yaitu pengumpulan data dengan menggunakan wawancara dan dokumentasi, penyusunan data dengan cara melakukan identifikasi atas peranan anggaran fleksibel sebagai alat pengendalian biaya produksi yang dilakukan oleh PT. Focon Interlite Pasuruan Jawa Timur. Berdasarkan hasil analisis varian biaya produksi dalam penyusunan anggaran biaya bahan baku langsung, yang menunjukkan bahwa dalam alokasinya dilakukan secara efisien. Kemudian varian biaya tenaga kerja langsung terdapat selisih yang menguntungkan (fovarable). Sedangkan penyusunan varian biaya overhead pabrik termasuk menguntungkan.Kata Kunci: Biaya Produksi, Anggaran Fleksibel, Pengendalian Biaya
Pengaruh Zakat Produktif dan Minat Berwirausaha Terhadap Peningkatan Pendapatan Masyarakat Miskin Pada BAZNAS Kota Gorontalo
Authors: Mardiana Andi , Lihawa Agustin Y 
Published: January 2022

In this research, writer to use quantitative method that is research wish to explain influence relationship and difference between variable X1 (Zakat Earning), X2 (interest of entrepreneurship) and variable Y (People Income) at baznas in Gorontalo city. The population in this research is 250 benefic of productive zakat and the samples are 71 samples. Method of sampling by random sampling. Sources of data in this study are primary data and secondary data. Zakat productive and entrepreneurial interests simultaneously have a positive and significant effect on increasing the income of poor people in Baznas KotaGorontalo. It is obtained from the test result f that is fcount of 17,597 with significant level 0.000 and ftabel = 3,13 with significant level 0,05, and also R Square value equal to 0,341 or 34,1%. In this case means that productive and entrepreneurial zakat affect the increase in income of the poor by 34.1%, while the rest of 65.9% influenced by other variables not examined in this study
ПРОБЛЕМИ ТА ПЕРСПЕКТИВИ ФІНАНСОВОЇ ДЕЦЕНТРАЛІЗАЦІЇ В УК- РАЇНІ
Authors: Kotyk O. V. , Liubovska M. M. 
Published: January 2022

У статті висвітлюється важливість перерозподілу фінансових потоків у процесі реформування місцевого самоврядування. Розглянуто механізми впровадження децентралізації в сучасній Україні. Проаналізовано й узагальнено наукові підходи до визначення змісту та ролі децентралізації у ринковій економіці. Досліджено питання реформи з децентралізації влади в Україні. Виділено переваги та недоліки реформування процесів розподілу фінансових ресурсів в Україні.
ФОРМУВАННЯ РИНКУ ЗЕМЛІ В УКРАЇНІ: ЗАБАГАНКА ЧИ НЕОБХІДНІСТЬ
Authors: Shvets F. D. , Pakharenko O. V. 
Published: January 2022

Наведено результати дослідження проблем становлення ринку землі в Україні. Проведено аналіз законопроектів про ринок земель в Україні та виявлено їх позитивні і негативні сторони. Запропоновано ряд практичних рекомендацій щодо розвитку ринку земель сільськогосподарського призначення. Наголошено на необхідності приведення нормативної грошової оцінки земель сільськогосподарського призначення до середньоєвропейського рівня та створення Державного банку землі.