bluuebunny/crossref_metadata_2025_split huggingface dataset:
Grape seed proanthocyanidin alleviates left ventricular remodeling by regulating systolic pressure, oxidative stress and vasoactive substances in spontaneously hypertensive rats
Authors: Liu Jianfei , Song Shujuan , Zhang Xu 
Published: March 2022

Purpose: To study the effect of grape seed proanthocyanidin (GSP) on left ventricular remodeling in spontaneously hypertensive rats, and the underlying mechanism.
Methods: Spontaneously hypertensive rats were randomly divided into two groups, with 12 rats per group. One group was injected with GSP. Systolic pressure in each group was measured at baseline (before treatment), and at 3, 6 and 9 weeks after treatment. Whole heart index and left heart index were calculated. Histopathological changes in myocardium and left ventricular posterior wall thickness of rats in each group were measured. The cross-sectional area of myocardial cells and myocardial collagen volume fraction were assessed. The levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), nitric oxide (NO), renin, angiotensin II (Ang II), endothelin-1 (ET-1) and endothelial nitric oxide synthase (eNOS) in each group of rats were assayed.
Results: Compared with the spontaneous hypertension group, whole heart mass index, left heart mass index, left ventricular posterior wall thickness, cross sectional area of myocardial cells, myocardial collagen volume fraction, and levels of MDA, renin, Ang II and ET-1 in GSP group were significantly decreased, while the expression levels of SOD, CAT, NO and eNOS were markedly increased in GSP group (p < 0.05). Cell hypertrophy in the GSP group was significantly mitigated, when compared with that in the spontaneous hypertension group.
Conclusion: GSP mitigates left ventricular remodeling in rats by reducing systolic blood pressure, improving antioxidant capacity and regulating levels of vasoactive substances, thus suggesting its potential for the management of hypertension.
Comparison of merits of DNA sequencing, PCR-SSCP and MFP assays in the detection of drug resistance in Mycobacterium leprae
Authors: Long Fan , Li JiuLong , Jia Jiedeng 
Published: March 2022

Purpose: To compare the merits of conventional Mouse Foot Pad (MFP) assay, Polymerase Chain Reaction-Single Strand Conformation Polymorphism (PCR-SSCP) analysis, and Direct-DNA sequencing in identification of drug resistance in M. leprae.
Methods: A total of 41 leprosy cases were investigated for drug resistance using MFP assay, whereby growth results were obtained in 23 cases. The DNAs extracted from these samples were amplified in polymerase chain reaction (PCR) using specific primers in order to determine the drug resistance-loci. Furthermore, PCRSSCP analysis was carried out using PCR amplicons, while gel electrophoresis was performed to identify any shift in mobility in any one of the DNA strands, as well as the pattern of mutation.
Results: A total of 5 isolates exhibited the highest degree of resistance R100, whereas 4 isolates showed intermediate level of resistance R10. In contrast, the least resistance was seen in R1. There were no mutations in 4 out of 10 strains which were dapsone-resistant, i.e., 1 HR, 2 IR and 1 LR. Moreover, there was no mutation in 305 bp sequence of the rpoB gene. DNA sequencing sensitivity was 60 %, whereas the sensitive isolates tested in the experiments exhibited no mutation, resulting in 100 % specificity.
Conclusion: These results indicate the advantages of molecular techniques over conventional MFP technique. The study has revealed that PCR-SSCP analysis, a rapid, specific and less expensive method, has greater potential for use in routine testing of the susceptibility of M. leprae to rifampicin and dapsone, than the other tests.
Keputusan Pembelian Produk Garnier Ditinjau Dari Kualitas Produk, Citra Merek dan Harga (Studi Kasus Mahasiswa Universitas Islam Batik Surakarta)
Authors: Tanjung Sari Nikmah Ayu , Kustiyah Eny , Istiqomah Istiqomah 
Published: March 2022

Abstrak. Tujuan penelitian guna melihat pengaruh variabel kualitas produk, citra merek dan harga terhadap keputusan pembelian produk Garnier di Universitas Islam Batik Surakarta secara simultan serta parsial. Deskriptif ialah jenis dari penelitian ini mempergunakan metode kuantitatif. Mengumpulkan data lewat studi kepustakaan serta kuesioner. Instrumen pada penelitian ini penyebaran kuesioner kepada 100 responden konsumen produk Garnier yang ditentukan mempergunakan teknik Purposive Sampling. Peneliti mempergunakan analisis uji regresi linier beranda. Uji tersebut meliputi koefisien determinasi, uji hipotesis, uji asumsi klasik, uji reliabilitas, dan uji validitas. Penelitian membuktikan dari hasil uji hipotesis yaitu dengan penyebaran kuesioner. Hasil kuesioner tersebut membuktikan hasil penelitian reliabel serta valid. Hasil uji asumsi klasik menyatakan penelitian ini tidak terjadi multikolinieritas serta heterokedastisitas. Hasil uji F didapatkan dari perihal ini menandakan bahwasanya kualitas produk, secara simultan citra merek serta harga berdampak signifikan dan positif pada variabel terikatnya yaitu keputusan pembelian. Sementara hasil uji t ditunjukkan kualitas produk dan citra merek secara positif serta signifikan berdampak pada keputusan pembelian produk Garnier di Universitas Islam Batik Surakarta, kemudian variabel harga secara tidak signifikan serta positif berpengaruh terhadap keputusan pembelian produk Garnier di Universitas Islam Batik Surakarta.
CAUSAS DA EVASÃO ESCOLAR NO ENSINO MÉDIO E ENSINO SUPERIOR: QUAL A INTERSEÇÃO?
Authors: Borges Monteiro Vitor , Wagner Martins João 
Published: March 2022

Uma série de estudos se dedicam ao estudo da evasão escolar na etapa de ensino fundamental e médio, indubitavelmente devido ao apelo constitucional da universalização do ensino nestes ciclos educacionais. Entretanto, deixa uma lacuna que vem sendo preenchida lentamente por estudos recentes que se dedicam a entender o comportamento da evasão no ensino superior. Apesar de evidente que houve uma mudança significativa do perfil do universitário brasileiro a partir do sistema de cotas, sabe-se que a heterogeneidade dentro das universidades ainda prevalece. Nesse sentido, o objetivo do trabalho consiste em realizar um levantamento bibliográfico sobre a evasão nos ensinos médio e superior no Brasil e discutir as causas da evasão e comparar suas peculiaridades em cada etapa. Através de um infográfico que mapeia as variáveis por etapa de ensino no tempo, conclui-se que no Ensino Médio as causas da evasão estão relacionadas aos problemas externos ao aluno, como ambiente socioeconômico e cultural, políticas públicas educacionais e também àqueles pertinentes a escola, como relação professor e aluno e tamanho da escola. Já a evasão universitária absorve problemas relacionados a questões pessoais, como aptidão ao curso, filhos, trabalho, distancia etc.
Upaya Guru dalam Menanggulangi Kesulitan Belajar Siswa
Authors: Yusriani Lisa , Junaidin Junaidin , Asrul Asrul 
Published: March 2022

Tujuan dalam penelitian ini adalah untuk mendeskripsikan Upaya Guru Dalam Menanggulangi Kesulitan Belajar Siswa Kelas V SD Negeri 02 Sawa Kabupaten Konawe Utara. Jenis penelitian ini adalah penelitian bersifat deskriptif kualitatif. Informan penelitian ini terdiri dari kepala sekolah, 4 orang Guru, dan 5 orang siswa. Teknik pengumpulan data dengan menggunakan observasi, wawancara, dan dokumentasi. Teknik analisis data yaitu pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian upaya guru dalam menanggulangi kesulitan belajar siswa kelas V SD Negeri 02 Sawa Kabupaten Konawe Utara dapat disimpulkan bahwa guru selalu berupaya dalam mengatasi kesulitan belajar siswa seperti: 1) memberi perhatian dan bimbingan langsung kepada siswa yang mengalami kesulitan belajar ketika proses pembelajaran sedang berlangsung, 2) memberikan buku-buku pelajaran agar anak lebih aktif belajar, baik belajar di sekolah maupun di rumah, 3) bekerjasama dengan orang tua siswa, 4) mengulangi beberapa mata pelajaran yang telah dipelajari yang dianggap sulit oleh siswa, 5) mengadakan belajar tambahan baik dilakukan di sekolah maupun di rumah pada mata pelajaran tertentu agar anak lebih paham dan mengerti terhadap materi pelajaran yang telah dipelajari.
Climate, land cover and topography: essential ingredients in predicting wetland permanence
Authors: Daniel Jody , Rooney Rebecca C. , Robinson Derek T. 
Published: March 2022

Abstract. Wetlands in the Prairie Pothole Region (PPR) are forecast
to retract in their ranges due to climate change, and potholes that typically
contain ponded water year-round, which support a larger proportion of
biological communities, are most sensitive to climate change. In addition to
climate, land use activities and topography also influence ponded water
amounts in PPR wetlands. However, topography is not typically included in
models forecasting the impacts of climate change on PPR wetlands. Using a
combination of variables representing climate, land cover/land use and
topography, we predicted wetland permanence class in the southern Boreal Forest,
Parkland and Grassland natural regions of the Alberta PPR (N = 40 000 wetlands). We show
that while climate and land cover/land use were strong predictors of wetland
permanence class, topography was as important, especially in the southern
Boreal Forest and Parkland natural regions. Our misclassification error rates for
the gradient boosting models for each natural region were relatively high
(43–60) though our learning rates were low (< 0.1) and our maximum
tree depths shallow (5–7) to balance bias and overfitting. Clearly, factors
in addition to climate, topography and land cover/land use influence
wetland permanence class (i.e., basin size, depth, ground water
connectivity, etc.). Despite classification errors, our results indicate
that climate was the strongest predictor of wetland permanence class in the
Parkland and Grassland natural regions, whereas topography was most
important in the southern Boreal Forest Natural Region among the three domains we considered.
Hubungan Aktivitas Belajar Mahasiswa Dengan Praktik Kebidanan Asuhan Kebidanan I (Kehamilan) di Prodi D-III Kebidanan Universitas Imelda
Authors: Simamora Debora Lestari 
Published: March 2022

Praktik mata kuliah Asuhan Kebidanan I (Kehamilan) di lahan praktik merupakan komponen yang sangat penting karena praktik mata kuliah Asuhan Kebidanan I (Kehamilan) merupakan proses pembelajaran dalam situasi nyata di institusi pelayanan kesehatan. Tujuan penelitian ini untuk mengetahui aktivitas belajar mahasiswa dengan praktik kebidanan Asuhan Kebidanan I (Kehamilan). Jenis penelitian ini adalah survei analitik dengan pendekatan cross sectional. Penelitian dilakukan di Prodi D-III Kebidanan Universitas Imelda. Populasi penelitian seluruh mahasiswa semester III sebanyak 70 orang, dan seluruhnya dijadikan sampel. Data dianalisis secara univariat dan bivariat dengan menggunakan uji Chi-Square. Hasil penelitian menunjukkan bahwa Aktivitas Belajar mahasiswa Prodi D-III Kebidanan Universitas Imelda dalam kategori cukup (50,0%). Hasil belajar mahasiswa pada Praktik Kebidanan Asuhan Kebidanan I dalam kategori baik (50,0%). Terdapat hubungan yang signifikan antara aktivitas belajar mahasiswa dengan hasil belajar praktik kebidanan Asuhan Kebidanan I mahasiswa Prodi D-III Kebidanan Universitas Imelda, dengan nilai signifikan (p)=0,000<0,05. Disarankan kepada Dosen Asuhan Kebidanan I (Kehamilan) untuk memotivasi mahasiswa agar dapat meningkatkan aktivitas belajarnya terutama dalam mempelajari Asuhan Kebidanan I (Kehamilan) sehingga pada saat praktek dapat lebih mudah mempraktekkannya.
JANDARMA TEŞKİLATI ÖZELİNDE CEZA HUKUKU GENEL HÜKÜMLERİ İLE CEZA MUHAKEMESİ HUKUKU KURALLARININ KOLLUK DİSİPLİN HUKUKUNDA UYGULANABİLİRLİĞİ
Authors: KARADENİZ Yusuf 
Published: March 2022

Devlet yapısı içerisinde Jandarma Genel Komutanlığı’nın ülke genelinde görevli üç genel kolluk kuvvetinden biri olarak teşkil edilmiş olması gereği öncelikle kolluk kavramı üzerinde genel bilgilendirme yapılacaktır. Bilahare yargısal içtihatlar ve öğretideki farklı görüşler kapsamında disiplin, disiplinin amacı, işlevi, türleri ile adli suç ve idari suç arasındaki benzerlik ve farklılıklar incelenecektir.
7068 Sayılı Genel Kolluk Disiplin Kanunu ise jandarma teşkilatı özelinde ele alınacak olması sebebiyle jandarma personelinin geçmişten günümüze tabi olduğu disiplin hükümlerinden de genel boyutta bahsedilecektir.
Disiplin suçları, karşılığında öngörülen yaptırımların ‘cebir’ içermesi bakımından adli suç ve cezalara yakınlaşmaktadır. Nitekim çalışmamızı üzerine kurduğumuz temel felsefe de işte tam bu noktada adli suç ve cezalarına uygulanan ceza hukukunun genel ve usul ilkelerinin disiplin hukukunda geçerli olması gerektiği düşüncesine ilişkindir. Bu düşünceyle çalışmamızın son bölümünde, öğretideki görüşler ve yargısal kararlar ışığında ceza hukuku genel hükümlerinin, disiplin hukuk bakımından ne boyutta uygulanabilir olduğu değerlendirilecektir.
Accuracy of Xpert MTB/RIF assay in diagnosis of tuberculosis a comparison to culture
Authors: Rishi Saqib , Hakak Rubeena , Dewani Safura 
Published: March 2022

Culture method is the most sensitive and specific method for the detection of Mycobacterium tuberculosis. Despite this, cultures are highly prone to contamination and the process can still take several days and does require expensive equipment, strict biosafety practices and well trained technical staff .Among the currently available Nucleic Acid Amplification Tests (NAAT), the Xpert MTB/RIF Assay (CB-NAAT), the LINE Probe Assay (LPA) and the Loop-Mediated Isothermal Amplification (LAMP) are endorsed by WHO for in vitro diagnosis of TB. The present study was carried out to assess the performance of CB-NAAT (Cepheid GeneXpert®) system for the diagnosis of MTB in both pulmonary and extra pulmonary specimens, within the demographic area of south Kashmir, India. Materials and methods: In this study Pulmonary & extra pulmonary specimens received at the Microbiology laboratory, from the new clinically suspected tuberculosis patients were used. The samples received at the laboratory were divided into three portions, one part each was used for AFB direct smear preparation, CB-NAAT and culture, respectively. A smear was reported positive if either the direct or the concentrated smear showed the presence of AFB. The concentrates were cultured on LJ media and incubated for up to 8 weeks.
Mineralization of the Bayan Obo Rare Earth Element Deposit by Recrystallization and Decarbonation
Authors: Wei Chun-wan , Deng Miao , Xu Cheng , Chakhmouradian Anton R. , Smith Martin P. , Kynicky Jindrich , Song Wen-lei , Chen Wei , Fu Bin 
Published: March 2022

AbstractThe genesis of the Bayan Obo giant rare earth element (REE) deposit has been debated for several decades. Here, we report the isotopic effects of dynamic recrystallization in the H8 carbonatite, which is the principal ore carrier in the deposit. We studied fresh drill core to a depth of 1.78 km and documented the elemental and C-O-Sr isotope evolution of rock-forming dolomite during its deformation and reaction with fluids. The precursor dolomite and the products of its recrystallization differ in δ13CVienna-PeeDee Belemnite (V-PDB) (–1.09 to 2.37 vs. –3.59 to 0.79‰, respectively) and 87Sr/86Sr (0.70241–0.70394 vs. 0.70288–0.71409, respectively), and show a similar δ18Ovienna-standard mean ocean water (V-SMOW) range (10.3–16.9‰). The strong negative shift in δ13CV-PDB indicates that, locally, there was as much as 40% loss of CO2 from the precursor dolomite, although most of the recrystallized dolomite experienced decarbonation on a smaller scale. Clumped monazite grains associated with apatite in paragenetically similar samples yielded variable in situ Th-Pb dates (980–340 Ma), whereas those in monomineralic veinlets give a consistent age of ~400 Ma and consistent initial Nd isotope ratios. This indicates that the wide range of dates may not represent real REE depositional events and that the primary REE minerals deposited in the Mesoproterozoic underwent isotopic reequilibration and REE remobilization in the mid-Paleozoic. Recrystallization and decarbonation of dolomite in the H8 unit were facilitated by its reaction with subduction-derived silica- and halogen-rich fluid, genetically linked to plate-convergence processes along the northern margin of the North China craton, and did not require an influx of REEs from an external source.
Early Childhood Education of Children with Special Needs in Malaysia: A Focus on Current Issues, Challenges, and Solutions
Authors: Saari Erni Marlina , Abdul Aziz Nor Azah , Rasli Roznim Mohamad , Mustafa Mazlina Che , Md Yassin Sopia 
Published: March 2022

This study aims to examine issues, challenges, and solutions concerning the current practices of teachers and operators of early childhood education teachers and operators of both public and private sectors in Malaysia. This research was based on a qualitative method involving a series of interviews, which were carried out at the Department of National Unity and Integration (Jabatan Perpaduan Negara dan Integrasi Nasional, JPNIN), the Department of Social Welfare (Jabatan Kebajikan Masyarakat, JKM), the Community Development Department (Jabatan Kemajuan Masyarakat, KEMAS), and several public and private preschools (for children aged 5-6 years) and childcare centers (for children aged 1 – 4 years). The sample of the study consisted of xxx practitioners, namely teachers, supervisors, operators, trainees, and officers, who were selected from several TASKA and TADIKA centers in Malaysia. In this study, Malaysia’s provisional Early Childhood Career Educator (ECCE) National Quality Framework (NQF) was analyzed, which helped highlight four critical standards relating to leadership, organization and management, children’s experiences, and learning opportunities, which have become a major concern among practitioners. Through the interviews, the researchers were able to record and interpret ECCE teachers’ perceptions of the need for a policy that emphasizes their professional and career development. As revealed in this study, practitioners had to face a host of challenges and issues relating to leadership, organization and management, children’s experiences, and learning opportunities, which could adversely affect their current practices. In tandem, several solutions were identified to help them overcome such problems. In summation, the findings suggest that teaching children with special learning needs can be extremely challenging that entails all concerned to take appropriate measures, with each party having to focus on its role to help provide equal access to education to all children. Surely, through concerted efforts, special needs education in Malaysia can be further improved to help children with learning disabilities to learn as efficacious as their mainstream counterparts.
Assessment of Postoperative Outcomes of Spine Fusion Patients With History of Cardiac Disease
Authors: Ahmad Waleed , Fernandez Laviel , Bell Joshua , Krol Oscar , Kummer Nicholas , Passfall Lara , Naessig Sara , Pierce Katherine , Tretiakov Peter , Moattari Kevin , Joujon-Roche Rachel , Williamson Tyler K. , Imbo Bailey , Vira Shaleen , Lafage Virginie , Paulino Carl , Schoenfeld Andrew J. , Diebo Bassel , Hassanzadeh Hamid , Passias Peter 
Published: March 2022

Introduction:
There is paucity on the effect of different cardiac diagnoses on outcomes in elective spine fusion patients.

Methods:
Patients undergoing elective spine fusion surgery were isolated in the PearlDiver database. Patients were stratified by having a previous history of coronary artery disease (CAD), congestive heart failure (CHF), valve disorder (valve), dysrhythmia, and no heart disease (control). Means comparison tests (chi-squared and independent samples t-tests, as appropriate) compared differences in demographics, diagnoses, comorbidities, procedural characteristics, length of stay, complication outcomes, and total hospital charges among the cohort.

Results:
In total, 537,252 elective spine fusion patients were stratified into five groups: CAD, CHF, valve, dysrhythmia, and control. Among the cohort, patients with CHF had significantly higher rates of morbid obesity, peripheral vascular disease, and chronic kidney disease (P < 0.001 for all). Patients with CAD had significantly higher rates of chronic obstructive pulmonary disease, diabetes, hypertension, and hyperlipidemia (all P < 0.001). Comparing postoperative outcomes for CAD and control subjects, CAD was associated with higher odds of myocardial infarction (odds ratio [OR]: 1.64 [1.27 to 2.11]) (P < 0.05). Assessing postoperative outcomes for CHF versus control subjects, patients with CHF had higher rates of pneumonia, cerebrovascular accident (CVA), myocardial infarction, sepsis, and death (P < 0.001). Compared with control subjects, CHF was a significant predictor of death in spine fusion patients (OR: 2.0 [1.1 to 3.5], P = 0.022). Patients with valve disorder compared with control displayed significantly higher rates of 30-day readmission (P < 0.05) and 1.38× greater odds of CVA by 90 days postoperatively (OR: 1.4 [1.1 to 1.7], P = 0.007). Patients with dysrhythmia were associated with significantly higher odds of CVA (OR: 1.8 [1.4 to 2.3], P < 0.001) by 30 days postoperatively.

Conclusion:
Heart disease presents an additional challenge to spine fusion patients who are undergoing a challenging and risky procedure. Before surgical intervention, a proper understanding of cardiac diagnoses could give insight into the potential risks for each patient based on their heart condition and preventive measures showing benefit in minimizing perioperative complications after elective spine fusion.
Méri István kapcsolata a magyar ősrégészeti kutatással. Korai évek a Magyar Nemzeti Múzeumban
Authors: Szathmári Ildikó 
Published: March 2022

A Régészeti osztály kerámia restaurátori műhelyének működése 1932 nyarán, Méri István munkába lépésével kezdődött. Új restaurálási módszereit főként az őskori kerámiák kiegészítésében alkalmazta. Jó gyakorlati érzékének, precíz rajzoló tehetségének köszönhetően számos ásatáson vett részt. Először 1933-ban Tompa Ferenc vitte magával a füzesabonyi bronzkori telep feltárására, ahol 1933 és 1937 között aktívan közreműködött a munkákban. Méri István első tanulmányai az őskorkutatáshoz, elsősorban az őskori edények készítéstechnikájának vizsgálatához kapcsolódnak.
Településszerkezeti megfigyelések nagykunsági késő középkori falvakban és a kiskunsági Szentkirályon
Authors: Pálóczi Horváth András 
Published: March 2022

A szerző terepbejárásokat végzett a Méri István által kutatott Túrkeve-mórici későközépkori falutelepülésen, ahol újabb jobbágyportákat és lakóházakat fedezett fel. Hasonló terepbejárásokkal vizsgálta meg a Karcag és Kisújszállás határában lévő kun szállásfalvak helyét s ezek tanulságait egybevetette az általa feltárt szentkirályi településsel.
The Roman Army along the Amber Road between Poetovio and Carnuntum in the 1st Century A.D. - Archaeological evidence. A preliminary research report
Authors: Mráv Zsolt 
Published: March 2022

The purpose o f my study is to shed light on the 1st Century Roman occupation o f NW-Pannonia by discussing the military sites along the 270 km long section of the Amber Road between two legionary fortresses, the Augustan Poetovio and the late Tiberio-Claudian Carnuntum. I will also examine the Roman occupation system of its two main branch roads, the Savaria-Brigetio and Scarbantia- Vindobona roads. Besides literary sources, my analysis is based on the archaeologically investigated and proved military buildings and fortifications of the period, the early import goods and inscriptions and, above all, the military equipment and horse gear finds which have long been regarded as characteristics of sites of military nature. The early history o f the Amber Road region is much more nuanced than scholars have hitherto realized, since the recently accumulated and tallied sources, primarily militaria finds, throw new light on the characteristic features of the Roman occupation system of this region.