bluuebunny/crossref_metadata_2025_split huggingface dataset:
Replies to Bergmann and Conee
Authors: Lycan William G. 
Published: September 2022

AbstractThis paper replies to commentary on my On Evidence in Philosophy, offered by critics Michael Bergmann and Earl Conee. It addresses their concerns regarding (1) whether my explanatory coherentism can explain the justification of introspective beliefs; (2) whether my epistemology is really coherentist rather than foundationalist; (3) my Principle of Humility; (4) my defense of free‐will compatibilism; (5) whether question‐begging is always unacceptable; and (6) whether intuitions qualify as evidence.
Cooperative feeding and foraging lateralization by Eden's whales off southern China
Authors: Chen Bingyao , Wu Caiwen , Ballance Lisa T , Fertl Dagmar , Jiang Huiping , Qiao Ying , Du Zhuoxuan , Zhang Yu , Yang Feng , Yang Guang , Pitman Robert L. 
Published: September 2022

AbstractWe investigated surface feeding behaviors of Eden's whales (Balaenoptera edeni edeni) in northern Beibu Gulf, southern China, between April 3, 2018, and April 26, 2021. During 122 days at sea, 1,065 individual feeding events were recorded, and eight feeding behaviors were identified: two nonlunging (tread‐water and/or trap‐feeding, 7.7%, and a novel behavior we call “pirouette feeding,” 15.3%) and six lunging (right lateral lunging, RLL, 10.9%; left lateral lunging, 0.2%; upright lunging, 6.3%, vertical lunging, 18.5%; inverted lunging, 0.3%; cooperative lateral lunging, COL, 40.9%). During COL, 2–8 whales swam clockwise around a fish school and simultaneously performed RLL on surfacing—the first cooperative feeding behavior recorded for a Balaenoptera whale. Five lateralized feeding behaviors (entailing either a left or right rotation on the long‐body axis) accounted for 65.8% of individual feeding events, with a strong right‐side bias (99.7%). Lateralized behavior is prevalent in many vertebrates, including several species of rorquals, and we suggest that the right‐biased foraging lateralization among rorquals specifically allows them to keep their right eye on their prey (i.e., a sensory versus motor lateralization), and that this shared asymmetry among conspecifics may have preadapted Eden's whale for cooperative foraging.
A standardized approach to airway management during Abbé flap reconstruction
Authors: Fernstrum Colton , Deichmann Paige , Duncan Forrest , Humphries Laura , Hoppe Ian 
Published: September 2022

AbstractBackgroundThe Abbé flap is a two‐staged procedure to address upper lip tightness, creating a surgically closed mouth during the first stage. Airway manipulation and management in the setting of a surgically closed mouth presents a challenge from an anesthetic standpoint.AimsThis study aims to describe the authors' standardized approach to airway management in cleft lip patients undergoing Abbé flap reconstruction.MethodsA retrospective review was performed including consecutive patients who underwent Abbe flap reconstruction at a single institution from 2019 to 2021. Five patients were included, and information regarding airway, intubation sequence, and emergence was gathered.ResultsDuring the initial surgery, the airway was secured via nasotracheal intubation to allow for adequate surgical exposure. On emergence, with a newly constructed surgically closed mouth, the anesthesiologist forfeits the ability to reintubate should the patient fail extubation without the use of nasal fiberoptic guided intubation or flap deinset. In addition, any coughing or tension on the surgical site could cause inadvertent disruption to the integrity of the new flap. Dexmedetomidine titrated to effect was used to allow for smooth emergence, with the surgeon present. During the second stage, the patient was kept spontaneously breathing while local anesthetic and intravenous anxiolytic allowed for pedicle division. The patient was then orally intubated, and the flap was inset. All five patients had successful reconstruction with no airway concerns or events.ConclusionsThe proposed standardized approach to airway management during Abbé flap reconstruction was safe and effective in this limited series of patients.
Loneliness andHbA1camong older Irish couples: Retirement as life stage context
Authors: Stokes Jeffrey E. , Barooah Adrita 
Published: September 2022

AbstractLoneliness is an important determinant of health and mortality among the aging population, including for cardiometabolic health. Yet research has largely focused on individual experiences of loneliness, rather than taking intimate relationships into account. However, recent studies have highlighted that loneliness of a partner may have implications for one's own health and well‐being as well. Indeed, this is particularly true among older couples, as life events and shifting time horizons (e.g., retirement, reduced social networks) can lead to greater prominence and salience of one's closest relationships. This study uses dyadic structural equation modeling (SEM) to estimate actor‐partner interdependence models (APIM) examining associations between loneliness and HbA1c levels among 1331 older married couples from The Irish Longitudinal Study on Aging (TILDA, 2009–2011). Furthermore, we test whether any such actor or partner effects vary by employment status. Results indicated that one's own loneliness was not significantly linked with HbA1c, irrespective of employment status. However, loneliness of a dyadic partner was significantly associated with elevated HbA1c among retired persons only. These findings underscore that relationship and life course context are crucial when considering the dyadic implications of loneliness for health among the older population.
Diversification in Caucasian Epeorus (Caucasiron) mayflies (Ephemeroptera: Heptageniidae) follows topographic deformation along the Greater Caucasus range
Authors: Hrivniak Ľuboš , Sroka Pavel , Godunko Roman J. , Manko Peter , Bojková Jindřiška 
Published: September 2022

AbstractThe evolution and distribution of mountain biota are closely linked with mountain formation and topographic complexity. Here we explore the diversification of cold‐tolerant mayflies of the subgenus Epeorus (Caucasiron) in the south‐eastern Greater Caucasus, an area of dynamic changes in topography since the Miocene, driven by the convergence of the Greater and Lesser Caucasus. We hypothesized that orogenic processes promoted the diversification of E. (Caucasiron) and that the resultant diversification pattern followed the timing and progress of mountain formation along the range. A new evolutionary lineage of E. (Caucasiron) distributed in the central‐eastern Greater Caucasus was found and described as Epeorus (Caucasiron) tripertitus sp.n. It consists of three clades clearly differentiated based on mitochondrial sequence data, but indistinguishable by morphological traits. Based on a time‐calibrated phylogeny using mitochondrial (COI, 16S) and nuclear (EF, wg, 28S) markers, we found that a gradual allopatric diversification of the ancestral population of E. (C.) tripertitus sp.n. dated to a period lasting from the late Miocene to the Pleistocene spread eastward along the range. This pattern corresponded with the process of topographic deformation which started in the central part of the range in the Miocene and progressed to the east during the Pliocene/Pleistocene. The results implied the dominant role of mountain building on the biotic diversification of this region and continuing recent speciation in the south‐eastern part of the mountains.
Physical Activity Intensity of Singles and Doubles Pickleball in Older Adults
Authors: Webber Sandra C. , Anderson Scott , Biccum Logan , Jin Sava , Khawashki Shahd , Tittlemier Brenda J. 
Published: September 2022

The purpose of this study was to measure heart rate, activity intensity, and steps in recreational singles and doubles pickleball players. We collected data in 22 singles and 31 doubles players (62.1 ± 9.7 years of age) using Garmin Fenix 5 watches (Garmin International, Inc.) and ActiGraph GT3X+ (ActiGraph LLC) accelerometers. Mean heart rates during singles and doubles were 111.6 ± 13.5 and 111.5 ± 16.2 beats/min (70.3% and 71.2% of predicted maximum heart rate), respectively. Over 70% of singles and doubles playing time was categorized in moderate to vigorous heart rate zones whereas 80.5% of singles time and 50.4% of doubles time were moderate based on Freedson accelerometer cut-points. Steps per hour were higher in singles versus doubles (3,322 ± 493 vs. 2,791 ± 359), t(51) = 4.540, p < .001. Singles and doubles pickleball are moderate- to vigorous-intensity activities that can contribute substantially toward older adults meeting physical activity guidelines.
Petrology of the Halifax County complex, North Carolina, Southern Appalachians: constraints from petrography, mineral chemistry, and geothermobarometry
Authors: Chaumba Jeff B. 
Published: September 2022

The Halifax County complex (HCC) is a meta-ultramafic/metamafic body that crops out along the easternmost exposed part of the Carolina superterrane in northeastern North Carolina. Petrographic and mineral chemistry studies were undertaken to place some constraints on the evolution of the HCC. Halifax County Complex amphiboles are zoned, with hornblende cores and actinolitic rims. Feldspar minerals span the whole plagioclase- and potassium-feldspar spectrum. Evolved olivines (Fo69–75) are primary, and pyroxenes plot in the enstatite, pigeonite, augite, and diopside fields. Low TiO2 (<0.8 wt.%) clinopyroxenes and highly calcic plagioclases are consistent with origin of the HCC at an island arc setting. Chlorites are characterized by wide variations in their Si atoms per formula unit but have restricted total Fe concentrations. Potassium feldspar in the HCC likely originated during adularization or potassification. Chlorite thermometry yields temperatures of formation of 241–300 °C. Application of hornblende-plagioclase thermometers yields average temperatures of 648 °C consistent with amphibolite facies conditions as well as greenschist facies conditions, at pressures of up to 6.5 kbar. Both clinopyroxene and evolved olivine compositions are consistent with an island arc origin for the HCC. Amphibolite facies metamorphisms recorded by HCC rocks likely represent metamorphism of the HCC during arc–arc terrane collision, whereas greenschist metamorphism is interpreted to record the temperatures of thrusting of the HCC onto its present location at pressures of <3 kbar in Alleghanian times during the final assembly of the Appalachians. Results reported here have implications for the origin of comparable metamorphosed mafic-ultramafic rocks encountered along ancient orogenic belts worldwide.
Square integrals of the logarithmic derivatives of Selberg’s zeta functions in the critical strip
Authors: Hashimoto Yasufumi 
Published: September 2022

In our previous work (Y. Hashimoto, Selberg’s zeta function for the modular group in the critical strip, Math. Nachr. 294 (2021) 1899–1904, https://doi.org/10.1002/mana.202000268 ), we proposed an upper bound of the logarithmic derivative of Selberg’s zeta function for the modular group in the critical strip. This paper studies the growth of its square integral for the modular group, co-compact arithmetic groups derived from indefinite quaternion algebras and their subgroups.
Explicit classification of isogeny graphs of rational elliptic curves
Authors: Barrios Alexander J. 
Published: September 2022

Let [Formula: see text] be an integer such that [Formula: see text] has genus [Formula: see text], and let [Formula: see text] be a field of characteristic [Formula: see text] or relatively prime to [Formula: see text]. In this paper, we explicitly classify the isogeny graphs of all rational elliptic curves that admit a nontrivial isogeny over [Formula: see text]. We achieve this by introducing [Formula: see text] parameterized families of elliptic curves [Formula: see text] defined over [Formula: see text], which have the following two properties for a fixed [Formula: see text]: the elliptic curves [Formula: see text] are isogenous over [Formula: see text], and there are integers [Formula: see text] and [Formula: see text] such that the [Formula: see text]-invariants of [Formula: see text] and [Formula: see text] are given by the Fricke parameterizations. As a consequence, we show that if [Formula: see text] is an elliptic curve over a number field [Formula: see text] with isogeny class degree divisible by [Formula: see text], then there is a quadratic twist of [Formula: see text] that is semistable at all primes [Formula: see text] of [Formula: see text] such that [Formula: see text].
Edge-SLAM: Edge-Assisted Visual Simultaneous Localization and Mapping
Authors: Ben Ali Ali J. , Kouroshli Marziye , Semenova Sofiya , Hashemifar Zakieh Sadat , Ko Steven Y. , Dantu Karthik 
Published: September 2022

Localization in urban environments is becoming increasingly important and used in tools such as ARCore [18], ARKit [34] and others. One popular mechanism to achieve accurate indoor localization and a map of the space is using Visual Simultaneous Localization and Mapping (Visual-SLAM). However, Visual-SLAM is known to be resource-intensive in memory and processing time. Furthermore, some of the operations grow in complexity over time, making it challenging to run on mobile devices continuously. Edge computing provides additional compute and memory resources to mobile devices to allow offloading tasks without the large latencies seen when offloading to the cloud.In this article, we present Edge-SLAM, a system that uses edge computing resources to offload parts of Visual-SLAM. We use ORB-SLAM2 [50] as a prototypical Visual-SLAM system and modify it to a split architecture between the edge and the mobile device. We keep the tracking computation on the mobile device and move the rest of the computation, i.e., local mapping and loop closing, to the edge. We describe the design choices in this effort and implement them in our prototype. Our results show that our split architecture can allow the functioning of the Visual-SLAM system long-term with limited resources without affecting the accuracy of operation. It also keeps the computation and memory cost on the mobile device constant, which would allow for the deployment of other end applications that use Visual-SLAM. We perform a detailed performance and resources use (CPU, memory, network, and power) analysis to fully understand the effect of our proposed split architecture.
Serum Sclerostin and Its Association with Bone Turnover Marker in Metabolic Bone Diseases
Authors: Chen Lihui , Gao Gao , Shen Li , Yue Hua , Zhang Ge , Zhang Zhenlin 
Published: September 2022

Sclerostin is a secreted inhibitor of Wnt/β-catenin signaling that is mainly produced by osteocytes and is an important regulator of bone remodeling. Some studies have evaluated serum sclerostin levels in metabolic bone diseases, but the results have been contradictory. The profile of serum sclerostin levels in patients with osteogenesis imperfecta (OI), X-linked hypophosphatemia (XLH), and Paget’s disease of bone (PDB) was obtained to determine their association with bone turnover marker. Serum sclerostin levels, biochemical parameters, and the bone turnover marker, β-CrossLaps of type 1 collagen containing cross-linked C-telopeptide (β-CTX), were measured in 278 individuals, comprising 71 patients with OI, 51 patients with XLH, 17 patients with PDB, and 139 age- and sex-matched healthy controls. A correlation analysis was performed between sclerostin and β-CTX concentration. The univariate logistic regression analysis was used to analyze factors associated with OI, XLH, and PDB. Patients with PDB (11 male 6 female), aged

44.47
±
14.75

years; XLH (17 male, 34 female), aged

19.29
±
15.65

years; and OI (43 male, 28 female),

aged

19.57
±
16.45

years, had higher sclerostin level than age- and sex-matched healthy controls [median(interquartile range): 291.60 (153.42, 357.35) vs. 38.00 (27.06, 68.52) pmol/L, 163.40 (125.10, 238.20) vs. 31.13 (20.37, 45.84) pmol/L, and 130.50 (96.12, 160.80) vs. 119.00 (98.89, 194.80) pmol/L, respectively;

P
<
0.001

]. Patients with PDB had the highest level of serum sclerostin, followed by those with XLH and OI (

P
<
0.05

). Sclerostin was positively correlated with β-CTX in OI and XLH (

r
=
0.541

and

r
=
0.661

, respectively;

P
<
0.001

). Higher β-CTX and sclerostin levels were associated with a higher risk of OI, XLH, and PBD. Sclerostin may be a biomarker of OI, XLH, and PDB. Whether sclerostin inhibitors can be used in these patients requires further analysis using additional cohorts.
Application of Optical Fiber Sensing Technology in Permeability Test of Three-Dimensional Physical Model of Medium and Long-Distance Diversion Tunnel
Authors: Xu Zhijing , Zhang Guanghui , Chen Xiaoming , Yao Liangxue , Chen Guangyao , Wang Fei 
Published: September 2022

In order to accurately simulate the dynamic change law of seepage field during construction, this paper proposes the application of optical fiber sensing technology in the permeability test of three-dimensional physical model of medium and long-distance headrace tunnel. This paper introduces the principle of optical fiber sensing, analyzes and compares the application advantages of optical fiber and general electrical signal sensing in the safety monitoring of long-distance diversion tunnel. Taking the safety monitoring of a 16# long tunnel of a diversion project as an example, the selection of monitoring sections, monitoring items, and the layout and networking of monitoring instruments are studied. In addition, combined with the tunnel project, the physical simulation of the construction process of the deep buried headrace tunnel under high seepage pressure is carried out, and the water pressure automatic control water supply system and the discrete flower tube seepage generation system are designed and manufactured to realize the high simulation of the seepage field. The seepage and evolution law in the surrounding rock of headrace tunnel during dynamic construction are calculated and analyzed. The test results show that the maximum external water pressure of the headrace tunnel is 15 MPa, which is equivalent to 1500 m head pressure, and the similar scale of head pressure is 100. Therefore, taking 15 m constant head water supply pressure for simulation calculation, the excavation of the tunnel is 120 cm, and the two-dimensional seepage of the vertical section of

Z
=
91

cm

. The seepage flow of the two sides of the tunnel is large, and the contour of the hydraulic gradient is dense. The coordinates are 0.7 m, 2.090 m, and 0.9 m. This point in the original rock mass is located at the same elevation point of the four headrace tunnels and directly below the model exploratory tunnel. The head pressure is 1.40 m, and the corresponding prototype point pressure head is 140 M. During construction, such a high external water pressure is a great safety hazard. Conclusion. The test conclusion provides a theoretical basis for the seepage prevention construction technology design of the headrace tunnel and is of great significance to the long-term stability, safety evaluation, and prediction of the headrace tunnel.
Oral Cancer Risk Assessment for Different Types of Smokeless Tobacco Products Sold Worldwide: A Review of Reviews and Meta-analyses
Authors: Gupta Alpana K. , Kanaan Mona , Siddiqi Kamran , Sinha Dhirendra N. , Mehrotra Ravi 
Published: September 2022

Abstract

Smokeless tobacco (SLT) use is a significant cause of lip and oral cavity cancers. Globally, oral cancer prevalence is strongly linked to the types of tobacco products used, their chemical composition, and their pattern of use. Except snus, all SLT products sold in different World Health Organization regions are strongly associated with oral cancer incidence. Shammah showed the highest association OR with 95% confidence intervals (CI; OR, 38.74; 95% CI, 19.50–76.96), followed by oral snuff (OR, 11.80; 95% CI, 8.45–16.49), gutkha (OR, 8.67; 95% CI, 3.59–20.93), tobacco with betel quid (OR, 7.74; 95% CI, 5.38–11.13), toombak (OR, 4.72; 95% CI, 2.88–7.73), and unspecified chewing tobacco (OR, 4.72; 95% CI, 3.13–7.11). Most SLT products containing high levels of carcinogenic tobacco-specific nitrosamines (TSNA) exhibit a high risk of oral cancer. There is an urgent need to frame and implement international policies for oral cancer prevention through legal control of the TSNA levels in all SLT product types.

Prevention Relevance:
Most smokeless tobacco products sold worldwide, mainly shammah, toombak, gutkha, betel quid with tobacco, and dry snuff, are associated with a high risk of oral cancer. A high concentration of tobacco-specific nitrosamines in smokeless tobacco products is the major causative factor for oral cancer development.
Transcriptomic Response to Calcium in Normal Colon Organoids is Impacted by Colon Location and Sex
Authors: Devall Matthew A.M. , Dampier Christopher H. , Eaton Stephen , Ali Mourad Wagdy , Plummer Sarah J. , Bryant Jennifer , Gauderman W. James , Peters Ulrike , Powell Steven M. , Casey Graham 
Published: September 2022

Abstract

Observational studies indicate that calcium supplementation may protect against colorectal cancer. Stratified analyses suggest that this protective effect may differ based on anatomic subsite and sex, but these hypotheses have been difficult to test experimentally. Here, we exposed 36 patient-derived organoid lines derived from normal colon biopsies (21 right colons, 15 left colons) of unrelated subjects (18 female, 18 male) to moderate (1.66 mmol/L) or high (5.0 mmol/L) concentrations of calcium for 72 hours. We performed bulk RNA-sequencing to measure gene expression, and cell composition was inferred using single-cell deconvolution in CIBERSORTx. We tested for significant differences in gene expression using generalized linear models in DESeq2. Exposure to higher levels of calcium was associated with changes in cell composition (P &lt; 0.05), most notably increased goblet and reduced stem cell populations, and differential expression of 485 genes (FDR &lt; 0.05). We found that 40 of these differentially expressed genes mapped to genomic loci identified through colorectal cancer genome-wide association studies, suggesting a potential biologic overlap between calcium supplementation and inherited colorectal cancer risk. Stratified analyses identified more differentially expressed genes in colon organoids derived from right sided colon and male subjects than those derived from left sided colon and female subjects. We confirmed the presence of a stronger right-sided effect for one of these genes, HSD17B2 using qPCR in a subset of matched right and left colon organoids (n = 4). By relating our findings to genetic data, we provide new insights into how nutritional and genetic factors may interact to influence colorectal cancer risk.

Prevention Relevance:
A chemopreventive role for calcium in colorectal cancer is still unclear. Here, we identify mechanisms through which calcium supplementation may reduce risk. Calcium supplementation increased differentiation and altered expression of colorectal cancer-related genes in a large study of patient-derived colon organoids. These findings were influenced by colon location and sex.