bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consumer preference for formal address and informal address from warm brands and competent brands
Authors: Leung Eugina , Lenoir Anne‐Sophie I. , Puntoni Stefano , van Osselaer Stijn M. J. 
Published: August 2022

AbstractWith the exception of Modern English, the world's major languages present advertisers and service providers with a choice: whether to address consumers using informal or formal pronouns (e.g.,tuorustedin Spanish). Yet, no research has investigated the impact of informal and formal address on consumer responses. In this paper, we show that brand personality affects consumers' preferences for, and responses to, pronominal address. In five studies, we establish that informal address is more likely to be preferred, and elicits higher preferences and more positive responses, when used by warmer brands; whereas formal address is more likely to be preferred, and elicits higher preferences and more positive responses, when used by more competent brands. These effects are replicated using a variety of contexts and designs. The implications of these findings are discussed.
Examining the effect of patient personality types and coping styles on outcomes of genetic counseling
Authors: Salman Areesha , Morris Emily , Inglis Angela , Austin Jehannine 
Published: August 2022

AbstractBoth empirical data and genetic counselors' clinical experience suggest that patients differ in the extent to which they benefit from genetic counseling (GC). Understanding the origins of these differences could help adapt services to ensure that all patients benefit fully, and potentially inform triage. Although patient personality dimensions and coping styles have been shown to influence outcomes of other psychological interventions, they have remained largely unexplored in relation to GC outcomes. We conducted an exploratory, descriptive study to assess relationships between patient personality dimensions, coping styles, and outcomes of GC. We recruited patients from a psychiatric genetics clinic who had – in the prior 7 years ‐ completed the GC Outcomes Scale (GCOS, a measure of empowerment) immediately prior to, and approximately one month after their appointment, and asked them to complete validated measures of personality and coping style. Interactions between each personality dimension or coping style and GCOS score were assessed using mixed‐effects linear regression models. Among the 169 participants, GCOS score increased by an average of 16.48 points (SD = 12.59). Though extraversion, conscientiousness, neuroticism, and all three coping styles significantly predicted GCOS score (p < 0.02), there was no relationship between these variables and time. For example, though a high score on conscientiousness predicted higher GCOS scores, it did not predict greater change in GCOS – people with higher scores on this dimension of personality had higher GCOS scores both pre‐ and post‐ GC. These preliminary data suggest that genetic counseling may increase empowerment regardless of personality dimensions and coping styles.
Analysis of long‐term trends and variations in extreme high air temperatures in May over Turkey and a record‐breaking heatwave event of May 2020
Authors: Erlat Ecmel , Türkeş Murat , Güler Hakan 
Published: August 2022

AbstractThis paper investigated the trends and variability in warmest daily maximum (TXx) and warmest daily minimum (TNx) air temperatures, and heatwave characteristics in Turkey in May during 1950–2020. It also analysed the climatological and synoptic meteorological evolutions of heatwave (HW) observed in May 2020. Trend analysis revealed significant increasing trends in TXx and TNx series and heatwave characteristics in May since 1950. Since the mid‐1980s, a continuously increasing trend in TXx and TNx series, and the number, frequency, and magnitude of the heatwaves were observed that accelerated with the mid‐1990s. The most severe heatwave in Turkey since 1950 in May was observed in 2020. The record‐breaking daily maximum (daily minimum) air temperatures were noted at 32 (23) of 96 stations in May 2020, mainly over Turkey's western and southern parts. Record‐high maximum (minimum) air temperature was 43.2°C (31.1°C) reached for the first time in May since 1950. The generalized extreme value model applied to the May TXx and TNx series revealed that the daily air temperatures in May 2020 exceeded 100 years' return periods at many stations of Turkey. This heatwave was linked to a regionalized strong anticyclonic blocking anomaly circulation and other associated atmospheric anomalies in May 2020. This also resulted in the centring of an unprecedented subsiding, calm, and stable warm air mass over Turkey. Adiabatic warming and drying developed very likely under subsidence control because of relatively weak circulation conditions. Such circumstances resulted in extremely hotter conditions in May 2020 compared to the long‐term averages.
Comparison of pesticide residue and specific nutrient levels in peeled and unpeeled apples
Authors: Lecerf Jean‐Michel , Périquet Alain , Carlin Frédéric , Lanckriet Suzanne , Paris Nicolas , Robaglia Christophe , Gleizer Bethsabée , Belzunces Luc , Cravedi Jean‐Pierre , Calvarin Johanna 
Published: August 2022

AbstractBACKGROUNDStudies have shown that the consumption of apples has a beneficial effect on cardiovascular diseases and some cancers, largely as a result of their micronutrient and phytoconstituent contents. Apple peel not only contains more polyphenols than the flesh, but also is likely to contain pesticide residues. The present study aimed to compare the contents of certain micronutrients and residual pesticide levels in peeled and unpeeled apples.RESULTSPeeled apples contained fewer pesticide residues at lower concentrations than unpeeled apples. However, whether samples were peeled or not, the exposure values for pesticide residues in apples never exceeded the acceptable daily intake (ADI), but ranged between 0.04% and 2.10% of the ADI in adults for food intake estimated at the 95th percentile (277 g per person per day). Determination of polyphenol, fibre, magnesium and vitamin C levels showed that the nutritional differences observed between peeled and unpeeled apples were marginal.CONCLUSIONThe consumption of apples, such as the apples tested in the present study, results in an exposure to pesticides that is low for unpeeled apples, and lower for peeled apples. Moreover, there was no significant loss of nutritional value from eating peeled apples based on the nutrients investigated. © 2022 Society of Chemical Industry.
α‐linolenic acid interconversion is sufficient as a source of longer chain ω‐3 polyunsaturated fatty acids in humans: An opinion
Authors: Burdge Graham C. 
Published: August 2022

Abstractα‐linolenic acid (αLNA) conversion into the functionally important ω‐3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), has been regarded as inadequate for meeting nutritional requirements for these PUFA. This view is based on findings of small αLNA supplementation trials and stable isotope tracer studies that have been interpreted as indicating human capacity for EPA and, in particular, DHA synthesis is limited. The purpose of this review is to re‐evaluate this interpretation. Markedly differing study designs, inconsistent findings and lack of trial replication preclude robust consensus regarding the nutritional adequacy of αLNA as a source of EPC and DHA. The conclusion that αLNA conversion in humans is constrained is inaccurate because it presupposes the existence of an unspecified, higher level of metabolic activity. Since capacity for EPA and DHA synthesis is the product of evolution it may be argued that the levels of EPA and DHA it maintains are nutritionally appropriate. Dietary and supra‐dietary EPA plus DHA intakes confer health benefits. Paradoxically, such health benefits are also found amongst vegetarians who do not consume EPA and DHA, and for whom αLNA conversion is the primary source of ω‐3 PUFA. Since there are no reported adverse effects on health or cognitive development of diets that exclude EPA and DHA, their synthesis from αLNA appears to be nutritionally adequate. This is consistent with the dietary essentiality of αLNA and has implications for developing sustainable nutritional recommendations for ω‐3 PUFA.
Array genotyping as diagnostic approach in medical genetics
Authors: Witsch‐Baumgartner Martina , Schwaninger Gunda , Schnaiter Simon , Kollmann Franziska , Burkhard Silja , Gröbner Rebekka , Mühlegger Beatrix , Schamschula Esther , Kirchmeier Peter , Zschocke Johannes 
Published: August 2022

AbstractGenotyping arrays are by far the most widely used genetic tests but are not generally utilized for diagnostic purposes in a medical context. In the present study, we examined the diagnostic value of a standard genotyping array (Illumina Global Screening Array) for a range of indications. Applications included stand‐alone testing for specific variants (32 variants in 10 genes), first‐tier array variant screening for monogenic conditions (10 different autosomal recessive metabolic diseases), and diagnostic workup for specific conditions caused by variants in multiple genes (suspected familial breast and ovarian cancer, and hypercholesterolemia). Our analyses showed a high analytical sensitivity and specificity of array‐based analyses for validated and non‐validated variants, and identified pitfalls that require attention. Ethical‐legal assessment highlighted the need for a software solution that allows for individual indication‐based consent and the reliable exclusion of non‐consented results. Cost/time assessment revealed excellent performance of diagnostic array analyses, depending on indication, proband data, and array design. We have implemented some analyses in our diagnostic portfolio, but array optimization is required for the implementation of other indications.
Detection of pericentric inversion with breakpoint in DMD by whole genome sequencing
Authors: Zaum Ann‐Kathrin , Nanda Indrajit , Kress Wolfram , Rost Simone 
Published: August 2022

AbstractBackgroundDystrophinopathies caused by variants in the DMD gene are a well‐studied muscle disease. The most common type of variant in DMD are large deletions. Very rarely reported forms of variants are chromosomal translocations, inversions and deep intronic variants (DIVs) because they are not detectable by standard diagnostic techniques (sequencing of coding sequence, copy number variant detection). This might be the reason that some clinically and histologically proven dystrophinopathy cases remain unsolved.MethodsWe used whole genome sequencing (WGS) to screen the entire DMD gene for variants in one of two brothers suffering from typical muscular dystrophy with strongly elevated creatine kinase levels.ResultsAlthough a pathogenic DIV could not be detected, we were able to identify a pericentric inversion with breakpoints in DMD intron 44 and Xq13.3, which could be confirmed by Sanger sequencing in the index as well as in his brother and mother. As this variation affects a major part of DMD it is most likely disease causing.ConclusionOur findings elucidate that WGS is capable of detecting large structural rearrangements and might be suitable for the genetic diagnostics of dystrophinopathies in the future. In particular, inversions might be a more frequent cause for dystrophinopathies as anticipated and should be considered in genetically unsolved dystrophinopathy cases.
Super‐UWB MIMO antenna with high isolation
Authors: Rahim Sajjad , Yang Xue‐Xia , Elobied Abubaker A. , Xiao Bo‐Zhong 
Published: August 2022

AbstractA 1 × 2 multiple‐input multiple‐output (MIMO) antenna with super‐ultra wideband (super‐UWB) operation and high isolation is proposed. The antenna element has an eye‐shape radiator fed by a tapered shape feedline on the top side and a defected ground structure etched on the bottom ground plane. A high isolation between two radiators is achieved by introducing a T‐shape and two small arm shape stubs at the center of the ground plane. The proposed design was verified by a fabricated prototype and measurement. The measured results show that the MIMO antenna achieves impedance bandwidth of 3 ~ 45 GHz, isolation of 21 dB, and a peak gain of 10.1 dBi. The envelope correlation coefficient is less than 0.02. The overall size of the design is only 0.26λ0L × 0.3λ0L (λ0L is the free space wavelength at 3 GHz).
A low phase noise dual‐band voltage‐controlled oscillator based on switchable tunable filter
Authors: Wang Hailong , Lai Jinming , Wang Chaojie , Li Zhiyou , Ma Xiaohua 
Published: August 2022

AbstractIn this letter, a parallel‐feedback dual‐band voltage‐controlled oscillator (DVCO) with low phase noise and a wide tuning range is proposed. The DVCO is composed of two tunable filters associated with four switches and an active device. By controlling four switches, the oscillation frequency can be switched and oscillated in one of two bands. The employed tunable filter with maintained passband shape and wide frequency tuning range (FTR) is beneficial to designing wideband DVCO with low phase noise. Owing to the maintained frequency response, the sharp phase variation and high in‐band group delay can be maintained during the filter tuning process, which can enhance the phase noise improvement. Moreover, the sharp phase variation can realize the phase compensation in a wide FTR when tuning the DVCO. To develop a DVCO with a simple circuit scheme, the two‐pole tunable filters with two different FTRs are designed. For verification, the proposed DVCO is designed, manufactured, and measured. The measurement results show that each band of the DVCO has a tuning range of 1.97–2.58 GHz (27.8%) and 2.934–3.468 GHz (16.7%), respectively. For the lower band, the phase noise at 100 kHz and 1 MHz frequency offset is better than −99.2 and −126.4 dBc/Hz, respectively. While for the upper band, the phase noise at 100 kHz and 1 MHz frequency offset is better than −101.2 and −127.4 dBc/Hz, respectively.
Emotional appeals effectiveness in enhancing charity digital advertisements
Authors: Yousef Murooj , Dietrich Timo , Rundle‐Thiele Sharyn , Alhabash Saleem 
Published: August 2022

AbstractAdvertising appeals effectiveness has long been a point of debate in the literature. This study empirically tests hope and shame online advertisements aimed at enhancing donation quality to charities. Following a sequential research design the current research carries two studies to tests the effect of hope and shame appeal messages on social media on behavioral engagement measures, guided by the multi‐actor engagement framework. Findings indicate shame appeals framed as losses are more effective in driving engagement than hope gain framed messages. The overall findings provide supporting evidence for the interplay between negative emotions and message framing. To achieve higher engagement and trigger behavior change while utilizing budgets effectively, charities would benefit from utilizing loss framed and shame inducing advertising messages.
A mixed‐methods evaluation of the experience of emerging young adult care partners
Authors: Marziliano Allison , Applebaum Allison , Siess Samantha , Moyer Anne 
Published: August 2022

AbstractThere is limited literature on emerging young adult (EYA) care partners, despite a recent rise in interest in this group. The purpose of this study is to compare EYA care partners and their non‐care partner peers in the domains of academic achievement and engagement, employment, health‐related behaviors and self‐care, and mental health and respite, as well as to assess EYA care partners’ burden and potential for positive psychosocial sequelae and life changes as a result of their role. Further, within EYA care partners, we examine the relationship between mental health variables and care partner‐relevant variables. Two hundred undergraduates (100 care partners and 100 non‐care partners) completed measures of academic achievement and engagement (grade point average and credit load), employment (number of paid positions held and number of hours worked per week), health‐related behavior/self‐care (visits to the dentist, primary care physician, optometrist, diet healthfulness, exercise, cigarette smoking, and drinks per week) and mental health/respite (depression, anxiety, loneliness, drinking, social support, peer pressure, vacation recency, and frequency). Care partners completed measures of spiritual well‐being, burden, meaning, and benefit‐finding, as well as provided qualitative feedback on how caregiving changed their lives. EYA care partners and non‐care partners did not differ on any variables examined except for the number of jobs held, as EYA care partners held more paid jobs than EYA non‐care partners. EYA care partners showed moderate burden and high levels of finding meaning/benefit, the latter of which was supported by the themes that emerged from their qualitative data. Within EYA care partners, we found that depression and anxiety (mental health variables) were significantly related to spiritual well‐being, burden, benefit finding, and finding meaning through caregiving (care partner‐relevant variables). It is encouraging that the care partner and non‐care partner groups were similar in domains critical for this age group, such as academic achievement and engagement.
Trials and adventures of the synthesis and evaluation of amphiphilic graft copolymers with dynamic topology
Authors: Kumler Margaret S. , Skinner Nicole M. , Meyersohn Marianne S. , Colt Tyler A. , Valverde Marvin , Powell Cameron E. , Costanzo Philip J. 
Published: August 2022

AbstractAmphiphilic graft copolymers were prepared via a grafting through approach to yield materials with a hydrophilic backbone and hydrophobic arms. The thermally responsive macromonomers were designed to contain a Diels–Alder adduct such that cyclo‐reversion would cleave the arms from the backbone thus altering polymer topology, composition and solubility. The macromonomers were prepared via light‐inducted atom transfer radical polymerization followed by post‐polymerization modification to install a polymerizable functionality. Next, free radical polymerization was employed to yield thermally responsive amphiphilic graft copolymers, whose solution state characteristics were extensively characterized by UV/Vis spectroscopy and fluorimetry. Due to the amphiphilic nature of the graft copolymer, some unexpected results occurred because of aggregation and solubility limitations. Furthermore, it was discovered that poly(N‐isopropyl acrylamide) exhibited distinct and unique aggregation properties by itself.
Twin Peak Quasi‐Periodic Oscillations and Stability via Thin‐Shell Formalism of Traversable Wormholes in Symmetric Teleparallel Gravity
Authors: Mustafa G. , Gao X. , Javed Faisal 
Published: August 2022

AbstractThis article explores the wormhole geometry in the background of symmetric teleparallel gravity or gravity, where is the non‐metricity term, and definite subject for the gravitational interaction. All the energy conditions are investigated for two different generic shape functions. The presence of exotic matter is confirmed due to the violation of the energy conditions. The epicyclic orbits of test particles around wormhole throat for the considered models are discussed. Twin peak Quasi‐periodic oscillations are calculated and presented with the required behavior. We also explore the physical characteristics and stable configuration of thin‐shell developed from the matching of inner obtained solution of wormhole geometry and outer black hole solution in gravity. The stability of shell is discussed by using the speed of sound parameter for both choices of shape functions, i.e., and . It is found that the position of event horizon does not change for different values of the physical parameter for the choice of while it changes for . We explore the proper length, shell energy and entropy of the developed structure for different values of physical parameters.
The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature
Authors: Derosa Giuseppe , D'Angelo Angela , Maffioli Pamela 
Published: August 2022

AbstractDysglycemia is a disease state preceding the onset of diabetes and includes impaired fasting glycemia and impaired glucose tolerance. This review aimed to collect and analyze the literature reporting the results of clinical trials evaluating the effects of selected nutraceuticals on glycemia in humans. The results of the analyzed trials, generally, showed the positive effects of the nutraceuticals studied alone or in association with other supplements on fasting plasma glucose and post‐prandial plasma glucose as primary outcomes, and their efficacy in improving insulin resistance as a secondary outcome. Some evidences, obtained from clinical trials, suggest a role for some nutraceuticals, and in particularBerberis,Banaba,Curcumin, andGuar gum, in the management of prediabetes and diabetes. However, contradictory results were found on the hypoglycemic effects ofMorus,Ilex paraguariensis,Omega‐3,Allium cepa, andTrigonella faenum graecum,whereby rigorous long‐term clinical trials are needed to confirm these data. More studies are also needed forEugenia jambolana, as well as forAscophyllum nodosumandFucus vesiculosuswhich glucose‐lowering effects were observed when administered in combination, but not alone. Further trials are also needed for quercetin.
A Novel Disposable Immunosensor for Early Diagnosis of Cardiovascular Diseases
Authors: Çalışkan Meltem , Vural Berfin , Sezgintürk Mustafa Kemal 
Published: August 2022

AbstractCardiovascular diseases are highly common cause of mortality and morbidity. It is envisaged that there is a relationship between cardiovascular diseases and ST2 (Suppression of Tumorigenicity 2) concentration of protein. In patients with cardiac insufficiency, the ST2 concentration was reported as higher than people without cardiac insufficiency. In this study ITO‐PET sheets (indium tin oxide covered terephthalate) was used as a working electrode for the fabrication of the immunosensor for ST2 protein. In the optimization experiments, important parameters responsible for biosensor fabrication have been optimized. After determining optimal conditions, reproducibility, repeatability, regeneration possibility, and analytical properties such as storage life are determined. The immunosensor showed a linear detection range for ST2 between 1–1500 fg/mL with a LOD value of 3.98 fg/mL. We also carried out SFI (single frequency impedance) experiments to monitor the specific interaction between ST2 and anti‐ST2, simultaneously. The developed immunosensor was successively applied to the determination of ST2 in commercial human serum sample.
Conformational Switching of Pyrenes Associated on Hairpin Loop Region by DNA B‐Z Transition
Authors: Nakamura Mitsunobu , Yoshioka Hibiki , Takada Tadao 
Published: August 2022

AbstractDNA B−Z transitions play an important role in biological systems and have attracted much attention in DNA nanotechnology. DNA and its analogues have also been used as templates to construct helical chromophore associates with π‐interactions. We prepared DNAs with consecutive non‐nucleoside pyrene residues in the middle of d(CG) repeat sequences. The pyrene‐labelled DNAs adopted a unimolecular hairpin structure, in which the pyrenes associated in the loop region. They exhibited inversion of exciton‐coupled circular dichroism signals that can be ascribed to pyrene association through a DNA B−Z transition. This indicates that the conformation of pyrene associates can be switched from right to left by the DNA B−Z transition. The fluorescence of the pyrene‐labelled DNA changed when switching the association. Thus, pyrene‐labelled DNA can be utilized as a chiroptical molecular switch.