bluuebunny/crossref_metadata_2025_split huggingface dataset:
CUR5g, a novel autophagy inhibitor, exhibits potent synergistic anti-cancer effects with cisplatin against non-small-cell lung cancer
Authors: Zhang Lu , Chen Jingxuan , Shen Yunpeng , Wu Bowen , Yang Peichang , Sun Gangchun , Liu Xiaoting , Qiang Pengfei , Gao Yamei , Sha Fangfang , Li Zirui 
Published: October 2022

Abstract

Autophagy, a highly conserved degradation process of eukaryotic cells, has been proved to be closely related to chemoresistance and metastasis of non-small-cell lung cancer (NSCLC). Autophagy inhibitors, such as chloroquine (CQ) and its derivative hydroxychloroquine (HCQ), has been shown to mediate anti-cancer effects in preclinical models, especially when combined with chemotherapy. However, the vast majority of autophagy inhibitors, including CQ and HCQ, actually disrupt lysosomal or/and possibly non-lysosomal processes other than autophagy. It is therefore of great significance to discover more specific autophagy inhibitors. In this study, after screening a series of curcumin derivatives synthesized in our laboratory, we found that (3E,5E)-1-methyl-3-(4-hydroxybenzylidene)-5-(3-indolymethylene)-piperidine-4-one (CUR5g) selectively inhibited autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g did not affect the lysosomal pH and proteolytic function, nor did it disturb cytoskeleton. CUR5g blocked the recruitment of STX17, a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein, to autophagosomesviaa UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. CUR5g alone did not induce apoptosis and necrosis of A549 cells, but significantly inhibited the mobility and colony formation of A549 cells. More excitingly, CUR5g showed no obvious toxicity to normal HUVECs invitroor mice invivo. CUR5g enhances the cisplatin sensitivity of A549 cells and effectively inhibited autophagy in tumor tissues invivo. Collectively, our study identified a new late-stage autophagy inhibitor and provided a novel option for NSCLC treatment, particular when combined with cisplatin.
Selected River Pollution in Bangladesh Based on Industrial Growth and Economic Perspective: A Review
Authors: Miah Md Helal , Chand Dharmahinder Singh , Malhi Gurmail Singh 
Published: October 2022

Abstract
The main goal of sustainable development is to engage the public in setting the groundwork for developing profiles based on carrying capacity assessments. Since industrial projects are located in traditional, non-industrial zones, the broad human resource development program includes environmental research, education, and training to build technical and practical skills in the country-based and scientific statistics system data gathering. It is noteworthy that the examinations were conducted sporadically and that the research did not correspond to the pollution level in Bangladesh's waterways. Therefore, it is essential to conduct a methodical examination that may offer a complete picture of river pollution so that appropriate preventative actions can be adopted to safeguard against pollution threats. Bangladesh has many environmental issues, including dirty air from various vehicles, unhealthy water, accumulating urban waste, untreated sewage, interior air pollution from wood smoke, and usage of fad-driven contemporary materials in homes. Each of them contributes more to the destruction of the environment. With the current trend of population growth followed by the construction of companies to suit their wants, such a situation may worsen. Hazardous gases, dust particles, or liquid effluents are the waste products emitted from industrial sources. These discharges are full of harmful chemicals that pollute aquatic ecosystems, disrupt the local biota, and eventually harm living things and associated flora and animals. As a result, studies were conducted, including the physicochemical characterisation of sugar refineries, distilleries, and other rivers that receive such effluents. These characteristics of subsurface water were also taken into consideration throughout the inquiry. This research will be anticipated to offer proper preventive methods for preserving the purity of the Bangladeshi rivers.
Efficacy of Bacopa monnieri on memory and vascular functions: A randomised controlled trial
Authors: Kamkaew Natakorn , Ingkaninan Kornkanok , Waranuch Neti , Kaewmahanin Watchara , Wasuntarawat Chanchira , Khongsombat Onrawee , Thiarawat Peeraphong , Roongpiboonsopit Duangnapa , Wattanathorn Jintanaporn , Scholfield C. Norman , Ngamdokmai Ngamrayu , Wisutthathum Sutthinee , Chatturong Usana , Inchan Anjaree , Chootip Krongkarn 
Published: October 2022

Abstract

Bacopa monnieri (L.) Wettst. (Brahmi) is a traditional memory enhancer partly by improved cerebral blood flow. Here we sought to link improved cognitive function with better blood flow in randomised double-blinded placebo-controlled trial in an elderly cohort. Normotensive Thais, aged 55-80y having mini-mental state examination (MMSE) scores > 25, no dementia or other psycho/neurological disease, normal lipid profile, and blood biochemistry were recruited. The trial design was a 2 week run-in, 12 week intervention of test product or placebo, and 4 week washout. The intervention was an extract ofB. monnierileaves (eBM) in 40 ml of mulberry juice. The placebo contained mulberry juice and other constituents to match gustatory properties. End-points were a battery of memory functions, carotid blood velocity, post-ischemic microvascular blood flow, markers of vascular inflammation, blood pressure and the blood markers. Response latency was reduced by 14.2 ± 4.9% (p = 0.022 comparing placebo) but only in > 65s. Other memory recall parameters were either unaffected or for ‘accuracy of recall’ was already maximal preventing further improvement. No change was detected in carotid blood velocity while microvascular blood flow marginally increased (by 28.4 ± 8.3%,p = 0.07). This preliminary evidence warrant further studies on selected patients with microvascular cognitive dysfunction using more discriminating protocols.
Clinical predictors and management for radial artery spasm: An Australian cross sectional study
Authors: Curtis Elizabeth , Fernandez Ritin , Khoo John , Weaver James , Lee Astin , Halcomb Elizabeth 
Published: October 2022

Abstract
Introduction
The transradial approach for coronary artery catheterisation has increased in popularity compared to the transfemoral approach for patients undergoing percutaneous coronary interventions. However, radial artery spasm continues to be a major complication of the procedure.
Aim
To identify the predictors of radial artery spasm and the medications used for its prevention and management.
Methods
A descriptive cross-sectional study was carried out across two tertiary hospitals in NSW, Australia. A self-administered pre-procedural survey was completed by patients undergoing coronary artery catheterisation. This survey collected socio-demographic data and assessed anxiety using the Spielberger State-Trait Anxiety Inventory. Procedural data, including length of procedure, equipment used, occurrence of radial artery spasm, and medications given, were collected post-procedure by the interventionalist.
Results
Of the 169 participants, over half were male (59.8%) and aged 66 years or older (56.8%). Radial artery spasm was reported in 24 (14.2%) participants. Rates of spasm were significantly higher among females (66.6%, p=0.004), those aged under 65 years (62.5%, p=0.001) and those who reported a medical history of anxiety (33.3%, p=0.0004). There were no significant differences in State and Trait anxiety scores among those who had RAS and those who did not. Logistic regression identified younger age as a statistically significant predictor of RAS (OR 0.536; 95% CI 0.171 to 1.684; p=0.005)
To prevent radial artery spasm most patients received midazolam (n=158; 93.5%), nitrates (n=133; 78.7%) and/or fentanyl (n=124; 73.4%) prophylactically. Nitrates were the most frequently administered medication to treat radial artery spasm (78.7%).
Conclusion
This study found greater clarity around predictors for RAS is required, as identifying patients at risk can ensure prophylactic measures are implemented. This study identified nitrates as the preferred vasodilator as a preventative measure along with the use of sedation.
Robust Advanced Modeling and Scheduling System (RAMS): From Space Exploration to Real-World Biomanufacturing
Authors: Saint-Guillain Michael , Sansdrap Isabelle , Brion Michaël , Pauly Eric 
Published: October 2022

Abstract
Advanced planning and scheduling (APS) systems aim at helping production and operation managers in organizing the manufacturing process of biotech products, finding near-optimal schedules meeting the demand, while taking operational resources and raw materials into account. We introduce an extension to APS, called Robust Advanced Modeling and Scheduling (RAMS), and present the first RAMS system: Rombio. Unlike existing APS systems, Rombio allows to (i) visually model the operational problem and context entirely (ii) generate and optimize schedules while taking uncertainty into account, and (iii) deal with a combination of various key performance indicators (KPIs). Probability theory enables us to cope with uncertainty, computing schedules that are robust to temporal deviations. Depending on the pursued KPIs, the resulting schedules optimize a combination of the following terms: the probability of satisfying the process constraints, the expected return/efficiency/quality, and even the operators’ wellness by minimizing its expected extra-hours. This introduces a new risk-aversion paradigm, replacing the well-known what-if and sensitivity analysis frameworks. Initially developed in collaboration with Nasa for space exploration, this versatile tool is applied to real-world biotechnology manufacturing in three different contexts: diagnostics, medicines and stem cells.
The Association of Regional Block with Intraoperative Opioid Consumption in Patients Undergoing Video-Assisted Thoracoscopic Surgery: a single-center, retrospective study
Authors: Yan Xiang , Liang Chen , Jiang Jia , Fu Yili , Wei Changwei 
Published: October 2022

Abstract
BACKGROUND: Regional block, such as thoracic epidural analgesia (TEA), thoracic paravertebral block (TPVB), or serratus anterior plane block (SAPB) has been recommended to reduce postoperative opioid use in recent guidelines, but the optimal options for intraoperative opioid minimization remain unclear. The aim of this study was to evaluate the intraoperative opioids-sparing effects of three regional blocks (TEA, TPVB, and SAPB) in patients undergoing video-assisted thoracoscopic surgery (VATs).
METHODS: This was a retrospective study of the adults undergoing VATs at a tertiary medical center between January 2020 and February 2022. According to the type of regional block used, patients were classified into 4 groups: GA group (general anesthesia without any regional block), TEA group (general anesthesia combined with TEA), TPVB group (general anesthesia combined with TPVB), and SAPB group (general anesthesia combined with SAPB). Cases were matched with a 1:1:1:1 ratio for analysis by age, sex, ASA physical status, and operation duration. The primary outcome was the total intraoperative opioid consumption standardized to Oral Morphine Equivalents (OME). Multivariable linear regression was used to estimate the association of the three regional blocks with the OME.
RESULTS: A total of 2159 cases met the eligibility criteria. After matching, 168 cases (42 in each group) were included in analysis. Compared with GA without any reginal block, the use of TEA, TPVB, and SAPB reduced the median of intraoperative OME by 78.45 mg (95% confidence interval [CI], -141.34 to -15.56; P=0.014), 94.92 mg (95% CI, -154.48 to -35.36; P=0.020), and 11.47mg (95% CI, -72.07 to 49.14; P=0.711), respectively.
CONCLUSIONS: The use of TEA or TPVB was associated with an intraoperative opioid-sparing effect in adults undergoing VATs, whereas the intraoperative opioid-sparing effect of SAPB was not yet clear.
Characterization of corrosion products formed on bronze ornaments excavated from the Chu tombs of the Spring and Autumn Periods in Dangyang, China
Authors: Cheng Xiaolin , Li Mo , Tang Lingran , Wu Na , Zhang Xin Yu 
Published: October 2022

Abstract

130 corrosion products on bronze ornaments excavated from the Chu tombs of the Spring and Autumn periods in Dangyang, Hubei Province, China, were examined by X-ray diffraction, and statistically analyzed. The results showed that the main corrosion products were cassiterite (SnO2), copper sulfates, and sulfides, and the rare tenorite (CuO). And corrosion products of different colors such as blue-green and black-gray were specifically detected by Raman spectroscopy. The Raman spectra of blue-green corrosion products were identified as Cu hydroxide sulfates and Cu hydroxide carbonate such as brochantite, posnjakite, antlerite and malachite, the black-gray corrosions were confirmed as copper sulfides, only the good quality Raman spectrum of covellite was obtained. The shifts of certain band positions in different Raman spectra of the black-gray corrosion products, as well as the causes of D and G peaks in the spectra were discussed. And the advantages and disadvantages of using Raman spectroscopy for the identification of corrosion products were presented and discussed. Finally, with reference to previous literature, it was proposed that the SO42 -ions and sulfate-reducing bacteria in the soil, along with the closed and anoxic burial environment, may explain the sulfate and sulfide corrosion products on the bronze ornaments. The presence of tenorite and charcoal indicates that the tombs might have undergone fire.
Probabilistic Coverage in Mobile Directional Sensor Networks: A Game Theoretical Approach
Authors: Golrasan Elham , Varposhti Marzieh 
Published: October 2022

Abstract
Directional sensor nodes deployment is indispensable to a large number of applications including Internet of Things applications. Nowadays, with the recent advances in robotic technology, directional sensor nodes mounted on mobile robots can move toward the appropriate locations. Considering the probabilistic sensing model along with the mobility and motility of directional sensor nodes, area coverage in such a network is more complicated than in a static sensor network. In this paper, we investigate the problem of self-deployment and working direction adjustment in directional sensor networks in order to maximize the covered area. Considering the tradeoff between energy consumption and coverage quality, we formulate this problem as a finite strategic game. Then, we present a distributed payoff-based learning algorithm to achieve Nash equilibrium. The simulation results demonstrate the performance of the proposed algorithm and its superiority over previous approaches in terms of increasing the area coverage.
Paraphilias in ADHD and their Association with Hypersexuality
Authors: Turner Daniel , Hertz Priscilla Gregorio , Biedermann Laura , Barra Steffen , Retz Wolfgang 
Published: October 2022

Abstract
Previous research has found some peculiarities in sexual functioning of adults with attention deficit/hyperactivity disorder (ADHD). So far, the prevalence of paraphilias in adults with ADHD is not known. We assessed the prevalence of paraphilic fantasies and behaviors in a sample of 160 adults with ADHD in comparison to 75 adults without ADHD. Furthermore, the association between paraphilias and hypersexuality was evaluated. All participants had to answer several questionnaires online. Both adults with and without ADHD reported high rates of paraphilic sexual fantasies and behaviors. Women without ADHD reported about frotteuristic fantasies more often, while women with ADHD reported about a higher rate of masochistic and fetishistic fantasies. On the other side, men without ADHD had a higher rate of fetishistic fantasies than men with ADHD. Hypersexuality was related to paraphilias in adults with ADHD, however, not in adults without ADHD. Furthermore, temper problems significantly predicted paraphilias in adults with ADHD. Altogether, individuals with ADHD seem to be not more prone to develop and act out paraphilic sexuality than controls. The results of the present study add to the current trend to depathologize paraphilic sexuality in the general as well as in clinical populations.
Associations Between Adverse Childhood Experiences and Early Adolescent Problematic Screen Use in the United States
Authors: Raney Julia H. , Ganson Kyle T. , Testa Alexander , Jackson Dylan B. , Singh Gurbinder , Sajjad Omar M. , Nagata Jason M. 
Published: October 2022

Abstract
Background
Problematic screen use, defined as loss of control over usage resulting in impairments in personal, social, and occupational functioning, has risen dramatically among adolescents. Adverse Childhood Experiences (ACEs) are important risk factors in the development of addictive behaviors and may play an important role in the development of problematic screen use.
Methods
Cross-sectional data from the Adolescent Brain Cognitive Development Study (Year 2; 2018-2020; N = 8,794) was analyzed in 2022. Multiple linear analyses were used to determine associations between ACEs and adolescent-reported problematic use of video games (Video Game Addiction Questionnaire), social media (Social Media Addiction Questionnaire), and mobile phones (Mobile Phone Involvement Questionnaire). Analyses were adjusted for potential confounders including age, sex, race/ethnicity, highest parent education, household income, and site.
Results
The 8,794 adolescent respondents ages 11-12 years old were racially and ethnically diverse (55.1% White, 19.5% Latino/Hispanic, 15.8% Black, 5.1% Asian, 3.2% Native American, 1.3% Other). ACEs were associated with higher problematic video game, social media, and mobile phone use in a dose-dependent fashion in both unadjusted and adjusted models.
Conclusions
Given the dose-dependent relationship in adolescent ACE exposure and rates of problematic screen use, public health programming for trauma-exposed youth should explore video game, social media, and mobile phone use among this population and implement interventions focused on supporting healthy digital habits.
A Possible Cause of Articular Cartilage Degeneration in the Acute Phase after Anterior Cruciate Ligament Reconstruction
Authors: Morita Yudai , Tajima Takuya , Yamaguchi Nami , Yokoe Takuji , Chosa Etsuo 
Published: October 2022

Abstract

Backgroud: To evaluate the influence of intra-articular hemarthrosis on activities of a disintegrin and metalloprotease with thrombospondin motifs (ADAMTS) family and matrix metalloproteases (MMPs) in the acute phase after anterior cruciate ligament reconstruction (ACLR).
Methods: Intra-articular hemarthrosis was collected from 17 patients who underwent primary ACLR on postoperative day POD1, POD4 and POD7. As control samples, synovial fluid without intra-articular hemarthrosis was obtained from ipsilateral knees prior to ACLR. ADAMTS-4, -5, and -9 and MMP-2 and -9 were measured by enzyme-linked immunosorbent assay (ELISA).
Results: Expression levels of ADAMTS-4 were significantly higher in POD4 and POD7 samples than in control (Pc-4<0.0001, Pc-7<0.0001). Expression levels of ADAMTS-5 were significantly higher in POD1 samples than in control samples (Pc-1=0.0007). MMP-2 expression levels in POD4 and POD7 samples were significantly increased compared to control samples (Pc-4=0.0017, Pc-7=0.0013). Expression levels of MMP-9 were increased in POD1, POD4 and POD7 samples, significantly higher than in control (Pc-1<0.0001, Pc-4<0.0001, Pc-7=0.0004).
Conclusion: These findings indicate that intra-articular hemarthrosis induces expression of ADAMTS-4, -5, MMP-2 and -9 in the acute phase, and especially increasing ADAMTS-4, -5 after ACLR may lead to cartilage degeneration. So intra-articular hemarthrosis may be suggested to remove as soon as possible after knee injury or surgery.
Towards Metacognition: Subject-Aware Contrastive Deep Fusion Representation Learning for EEG Analysis
Authors: Briden Michael , Norouzi Narges 
Published: October 2022

Abstract
We propose a subject-aware contrastive learning deep fusion neural network framework for effectively classifying subjects' confidence levels in the perception of visual stimuli. The framework, called WaveFusion, is composed of lightweight convolutional neural networks for per-lead time-frequency analysis and an attention network for integrating the lightweight modalities for final prediction. To facilitate the training of WaveFusion, we incorporate a subject-aware contrastive learning approach by taking advantage of the heterogeneity within a multi-subject electroencephalogram dataset to boost representation learning and classification accuracy. The WaveFusion framework demonstrates high accuracy in classifying confidence levels by achieving a classification accuracy of 95.7% while also identifying influential brain regions.
Deoxyguanosine kinase mutation F180S is associated with a lean phenotype in mice
Authors: Borreguero Cédric Francis , Wuest Stephan , Hantel Constanze , Schneider Holger , Konrad Daniel , Beuschlein Felix , Spyroglou Ariadni 
Published: October 2022

Abstract
Background
Deoxyguanosine kinase (DGUOK) deficiency is one of the genetic causes of mitochondrial DNA depletion syndrome (MDDS) in humans, leading to the hepatocerebral or the isolated hepatic form of MDDS. Mouse models are helpful tools for the improvement of understanding of the pathophysiology of diseases and offer the opportunity to examine new therapeutic options.
Methods
Herein, we describe the generation and metabolic characterization of a mouse line carrying a homozygous DguokF180S/F180S mutation derived from an N-ethyl-N-nitrosourea-mutagenesis screen. Energy expenditure, oxygen consumption (VO2) and carbon dioxide production (VCO2) were assessed in metabolic cages. LC-MS/MS was used to quantify plasma adrenal steroids. Plasma insulin and leptin levels were quantified with commercially available assay kits.
Results
Mutant animals displayed significantly lower body weights, reduced inguinal fat pad mass, but normal liver weights in comparison to unaffected littermates. Biochemically, they were characterized by pronounced hypoglycemia accompanied with hypoinsulinemia and significantly lower total cholesterol, high density lipoprotein and triglyceride levels. Moreover, energy expenditure was significantly higher in mutant compared to littermate mice. Histological examination of inguinal white adipose tissue (WAT) revealed adipocytes with multilocular fat droplets reminiscent of WAT browning. In addition, mRNA expression of Ucp1 was increased. Mutant mice also presented differing mitochondrial DNA content in various tissues and altered metabolic activity in mitochondria, but no further phenotypical or behavioral abnormalities. Preliminary data imply normal survival of DguokF180S/F180S mutant animals.
Conclusion
These data are suggestive of the presence of compensatory mechanisms in the context of this specific mutation, ensuring sufficient mitochondrial DNA levels that do not further influence phenotype and survival.