bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality and cause of death in multiple sclerosis in western Norway 1950–2021: a registry-based linkage study
Authors: Willumsen Johannes Sverre , Grytten Nina , Aarseth Jan , Myklebust Tor Åge , Myhr Kjell-Morten , Midgard Rune 
Published: September 2022

BackgroundPersons with multiple sclerosis (pwMS) have higher risk of mortality compared with the general population. Longitudinal studies are important for understanding the evolution of survival in pwMS.ObjectiveExamine changes in mortality among pwMS during the past seven decades.MethodsWe followed pwMS from Hordaland and Møre and Romsdal in Western Norway, with disease onset from before 1950, identified from population-based epidemiological surveys and the Norwegian MS Registry and Biobank, until 1 January 2021. Data were linked to the Norwegian Cause of Death Registry to obtain underlying cause of death. We examined all-cause, and cause-specific mortality using standardised mortality ratios (SMR) and excess death rates (EDR). We calculated life expectancies and assessed survival stratified by sex, age and disease phenotype at onset. We compared hazard ratios (HRs) for mortality, in pwMS diagnosed before and after the era of disease-modifying treatment (DMT).ResultsOf 3624 pwMS, 964 (55.5% women) had died, predominantly of multiple sclerosis (49.0%). Median life expectancy for pwMS was 74.3 years (95% CI 73.3 to 75.3), compared with 83.1 years for the general population (p<0.001). From disease onset, pwMS survived 14.6 years shorter than the general population (p<0.001). Overall, SMR was 2.3 (95% CI 2.13 to 2.42) and EDR was 6.8 (95% CI 6.42 to 7.09) for pwMS. Treatment-eligible pwMS diagnosed in the DMT era had the lowest risk of mortality, HR 0.49 (95% CI 0.34 to 0.70,p<0.001).ConclusionExcess mortality among pwMS declined during the past seven decades, possibly due to improved diagnostics, better symptomatic treatment and access to DMTs.
Clinical utility of cerebrospinal fluid biomarkers in the evaluation of cognitive impairment: a systematic review and meta-analysis
Authors: Hazan Jemma , Wing Michelle , Liu Kathy Y , Reeves Suzanne , Howard Robert 
Published: September 2022

BackgroundThe analytical and clinical validity of cerebrospinal (CSF) biomarkers has been extensively researched in dementia. Further work is needed to assess the ability of these biomarkers to improve diagnosis, management and health outcomes in the clinical settingObjectivesTo assess the added value and clinical utility of CSF biomarkers in the diagnostic assessment of cognitively impaired patients under evaluation for Alzheimer’s disease (AD).MethodsSystematic literature searches of Medline, EMBASE, PsycINFO and Web of Science research databases were conducted on 17 December 2022. Data from relevant studies were extracted and independently screened for quality using a tool for bias. Clinical utility was measured by clinicians’ changes in diagnosis, diagnostic confidence and patient management (when available), after their examination of patients’ CSF biomarkers. Cost-effectiveness was assessed by consideration of additional cost per patient and quality-adjusted life years.ResultsSearches identified 17 studies comprising 2090 patient participants and 593 clinicians. The meta-analysis revealed that clinicians’ use of CSF biomarkers resulted in a pooled percentage change in diagnosis of 25% (95% CI 14 to 37), an increase in diagnostic confidence of 14% (95% CI 9 to 18) and a pooled proportion of patients whose management changed of 31% (95% CI 12 to 50). CSF biomarkers were deemed cost-effective, particularly in memory services, where pre-test AD prevalence is higher compared with a primary care setting.ConclusionsCSF biomarkers can be a helpful additional diagnostic tool for clinicians assessing patients with cognitive impairment. In particular, CSF biomarkers consistently improved clinicians’ confidence in diagnosing AD and influenced on diagnostic change and patient management. Further research is needed to study the clinical utility of blood-based biomarkers in the clinical setting.
Medical correlates of first-term attrition in US Navy personnel
Authors: Elkins Trevor Alan , MacGregor A , Dougherty A , Olson A 
Published: September 2022

IntroductionFirst-term attrition (FTA), or failure of a military service member to complete their initial service contract, is a major financial burden and source of lost manpower in the US Navy. The objective of the present study was to examine medical correlates of FTA using healthcare and disability rating data.MethodsIn this retrospective cohort study, all US Navy-enlisted personnel between the years 2003 and 2018 with FTA (n=58 777) and regular discharge (n=203 084) were identified for analysis from accession dates in the Career History Archival Medical and Personnel System. Medical diagnoses from outpatient and inpatient records were abstracted from the Military Health System Data Repository. For a subgroup of the study population discharged with a disability rating (n=12 880), diagnoses were identified from the Integrated Disability Evaluation System. The FTA and regular discharge groups were compared using relative risks (RRs) and 95% CIs, and per cent differences for the disability subgroup analysis.ResultsCompared with regular discharges, those with FTA were more likely to have outpatient and inpatient diagnoses for mental health disorders. Personality disorder yielded the strongest association with FTA in both outpatient (RR=10.45, 95% CI 9.79 to 11.16) and inpatient settings (RR=18.97, 95% CI 14.16 to 25.42). Other disorders associated with FTA included schizophrenia, substance-related disorders, poisoning by psychotropic agents and adjustment disorders. In the disability analysis, the FTA group relative to regular discharges had the largest per cent differences for ‘arthritis, degenerative (hypertrophic or osteoarthritis)’ (10.8% vs 2.5%) and ‘tibia and fibula, impairment’ (3.0% vs 0.4%).ConclusionsThis study provides evidence that FTA is associated with both mental and physical health conditions. Mental and physical factors related to FTA require further examination, particularly whether pre-enlistment screening or early career intervention could lead to mitigation strategies. Future research should extend this analysis to other services and population subgroups.
Gromov–Witten invariants of Hilbert schemes of two points on elliptic surfaces
Authors: Alhwaimel Mazen M. , Qin Zhenbo 
Published: September 2022

In this paper, we study the Gromov–Witten theory of the Hilbert scheme [Formula: see text] of two points on an elliptic surface [Formula: see text]. Assume that [Formula: see text] contains an element supported on the smooth fibers of [Formula: see text]. By analyzing the degeneracy locus and localized virtual cycle arising from the cosection localization theory of Kiem and Li [Y. Kiem and J. Li, Gromov–Witten invariants of varieties with holomorphic 2-forms, preprint; Y. Kiem and J. Li, Localizing virtual cycles by cosections, J. Amer. Math. Soc. 26 (2013) 1025–1050], we determine the [Formula: see text]-point genus-[Formula: see text] Gromov–Witten invariant [Formula: see text] up to some rational number [Formula: see text] depending only on [Formula: see text] and [Formula: see text], where [Formula: see text], [Formula: see text], [Formula: see text] is a smooth fiber of [Formula: see text], [Formula: see text] with [Formula: see text] being a fixed point, and [Formula: see text]. Moreover, we propose a conjecture regarding [Formula: see text], and prove that the conjecture is true for [Formula: see text] where [Formula: see text] is an elliptic curve and [Formula: see text] is a smooth curve.
RESEARCH ON ROPE-DRIVEN FLEXIBLE ROBOT FOR HAND REHABILITATION AND EXPERIMENTAL STUDY BASED ON EEG SIGNALS
Authors: GUO KAI , ORBAN MOSTAFA , YANG HONGBO , LI ZHENLAN 
Published: September 2022

Dysfunction of hand after stroke can affect patients’ ability to perform daily activities and social ability. This paper developed a flexible hand function rehabilitation robot based on sensory input. First, we designed a flexible external finger muscle based on rope drive, then we designed a special two-way output linear actuator to drive fingers for rehabilitation training. At the same time, we performed vibration stimulation on each finger of the patient and low-frequency electrical stimulation on the patient’s wrist. Sensory stimulation mobilizes the active participation of the brain in rehabilitation training, thereby effectively promoting the rehabilitation effect of fine functions of fingers after stroke. We have completed the hardware design of the flexible hand robot and developed the control software of the flexible hand, thus completing the development of the hand function robot. Finally, experiments were carried out on the use of equipment by using EEG. Experiments show that when the flexible hand robot developed in this paper is used for training, it mobilizes the active participation of the brain in rehabilitation training.
EFFECTS OF THE WINBACK THERAPY ON PAIN AND PHYSIOLOGICAL CHARACTERISTICS OF THE TRAPEZIUS IN PATIENTS WITH WORK-RELATED MUSCULOSKELETAL DISORDERS
Authors: YOON SAMWON , PARK CHANHEE , PARK ILBONG , LEE CHAEKWAN , CHA YOUNGJOO 
Published: September 2022

The purpose of this study is to investigate how the pain and physiological characteristics of the trapezius change when the Winback therapy is applied to the trapezius in patients with work-related musculoskeletal disorders (WMSDs). This study was conducted on 30 healthy adults living in Jeju Island. After applying the Winback 3SE high-frequency equipment developed in France, the muscle tone, muscle stiffness, pressure pain threshold, and visual analog scale (VAS) of the trapezius were measured. After the intervention, muscle tone decreased from 16.15 ± 2.02 to 14.22 ± 1.83, muscle stiffness decreased from 285.81 ± 58.26 to 245.83 ± 51.62, pressure pain threshold increased from 62.58 ± 23.28 to 79.38 ± 28.27, and VAS decreased from 3.73 ± 0.73 to 1.01 ± 0.02. These improvements were statistically significant (p < 0.05), and the muscle tone, muscle stiffness, pressure pain threshold improved in the experimental group compared to the control group. The Winback therapy was effective in reducing muscle tone, muscle stiffness, and pain of trapezius in WMSDs.
EFFECT OF MASSOTHERAPY ON THE FATIGUE RECOVERY USING THE SMART MASSAGE CHAIR: A RANDOMIZED CONTROLLED TRIAL
Authors: FU MEIHONG , SUN CHONG , LIU TANGYI , LI SHAOXIONG 
Published: September 2022

Objective: This study was envisaged to scientifically analyze the efficacy of the massage chair in reducing the fatigue using the heart rate variability (HRV) and fatigue self-assessment scale (FSAS) in a randomized clinical trial. Methods: 240 fatigue volunteers were divided into the massage chair intervention group and the control group using a completely randomized method. The kneading, pressing, tapping, and flapping techniques in the smart massage chair were used to intervene on the volunteers. The FSAS, HRV, and blood oxygen saturation changes were observed before and after the intervention, and the effect of massage in the smart massage chair to relieve fatigue was explored. Results: The overall exhaustion, mental fatigue, and physical fatigue scores of the FSAS were statistically significant (P < 0.05) before and after the intervention. After the intervention, the overall fatigue, mental fatigue, and physical fatigue scores of the experimental group were significantly lower than those of the control group. The HRVhf, HRVlf, and HRVlf/hf in HRV before and after the intervention between the two groups were statistically significant (P < 0.05), and the HRVhf values of the two groups were significantly increased after the intervention. The HRVlf value was significantly reduced, and the HRVlf value of the control group was increased. After the intervention, the HRVlf/hf value of the experimental group was significantly reduced, and the HRVlf/hf value of the control group increased. There were no significant differences in the HR and SpO2 values (P > 0.05). Conclusion: The massaging approach of the smart massage chair significantly reduced the tiredness scale score of the volunteers, reduced the sympathetic nerve excitability, and increased parasympathetic nerve excitability. The results indicate that the smart massage chair can be used as an effective method for short-term fatigue recovery.
Gerenciamento documental integrado à gestão de conservação: protocolos para o acervo artístico da UFMG
Authors: Panisset Ana Martins , Froner Yacy-Ara 
Published: September 2022

Este artigo enfatiza a importância dos processos de documentação para uma gestão integrada de coleções, a partir do princípio de que o gerenciamento documental é uma das ferramentas indispensáveis para sua preservação. Aborda os protocolos desenvolvidos para políticas de documentação e gestão do Acervo Artístico da UFMG, destacando a especificidade dos acervos universitários. Constituído ao longo da trajetória da UFMG, esta coleção possui hoje aproximadamente 1700 objetos, entre pinturas, gravuras, desenhos, aquarelas, paisagens, retratos, fotografias, livros de artistas, esculturas e murais, englobando desde o século XVI ao XXI. A fim de problematizar a inserção e a formação de acervos nas universidades, o texto discute aspectos que envolvem a história e o desdobramento de ações que perspectivam o reconhecimento, a gestão, a salvaguarda e a necessidade de articulação nos âmbitos locais, nacionais e internacionais. Tais acervos, embora acumulados no âmbito da universidade, têm origem distinta, o que demanda uma percepção diferenciada de seus registros. Diante de tais desafios, é fundamental estabelecer subsídios para a discussão da necessidade da documentação para conhecimento e visibilidade dos acervos universitários. O reconhecimento das bases teóricas, dos princípios conceituais das ferramentas operacionais e dos protocolos estruturantes de gestão é fundamental para o estabelecimento de políticas de gestão de acervos no âmbito universitário, perspectivando sua integração às ações universitárias de ensino, pesquisa e extensão.
The availability and completeness of open funder metadata: Case study for publications funded by the Dutch Research Council
Authors: Kramer Bianca , de Jonge Hans 
Published: September 2022

Abstract
Research funders spend considerable efforts collecting information on the outcomes of the research they fund. To help funders track publication output associated with their funding, Crossref initiated FundRef in 2013, enabling publishers to register funding information using persistent identifiers. However, it is hard to assess the coverage of funder metadata because it is unknown how many articles are the result of funded research and should therefore include funder metadata. In this paper we looked at 5,004 publications reported by researchers to be the result of funding by a specific funding agency: the Dutch Research Council NWO. Only 67% of these articles contain funding information in Crossref, with a subset acknowledging NWO as funder name and/or Funder IDs linked to NWO (53% and 45%, respectively). Web of Science (WoS), Scopus, and Dimensions are all able to infer additional funding information from funding statements in the full text of the articles. Funding information in Lens largely corresponds to that in Crossref, with some additional funding information likely taken from PubMed. We observe interesting differences between publishers in the coverage and completeness of funding metadata in Crossref compared to proprietary databases, highlighting the potential to increase the quality of open metadata on funding.
Two new species of Oswaldocruzia (Nematoda, Molineidae) parasitising lizards in Ukraine
Authors: SVITIN ROMAN 
Published: September 2022

Two new species, Oswaldocruzia lisnykiensis sp. n. and Oswaldocruzia lacertica sp. n., are described from Anguis fragilis L. (Reptilia: Anquidae) and Lacerta agilis L. (Reptilia: Lacertidae) respectively. Both species belong to the Palaearctic group of species which have spicules divided in three main branches (blade, fork and shoe) with fork division above its distal third. The new species differs from all previously known Palaearctic species by several morphological characters: type of caudal bursa (type III in O. lisnykiensis and type I in O. lacertica), shape of spicules (blade distally divided into four tips and specific shape of shoe) and synlophe structure (narrow cervical alae consist of three crests in both species). Illustrated descriptions of O. lisnykiensis and O. lacertica based on 63 and 38 specimens respectively are presented. Host specificity and geographical distribution of the species are discussed. O. dispar is considered as a species inquirenda.
Relocation of GATE from the Pacific to the Atlantic
Authors: Zhang Chidong , Wallace John M. , Houze Robert A. , Zipser Edward J. , Emanuel Kerry A. 
Published: September 2022

Abstract
This article documents historically the planning of the Global Atmospheric Research Program’s (GARP) Atlantic Tropical Experiment (GATE), the largest atmospheric field program of all time. In its earliest planning, GATE was called the Tropical Meteorological Experiment (TROMEX) and was designed to be in the tropical western Pacific. For reasons including concerns of the U.S. Department of Defense, the international project was relocated to the tropical Atlantic and renamed GATE.
Tγδ LGLL identifies a subset with more symptomatic disease: analysis of an international cohort of 137 patients
Authors: Barilà Gregorio , Grassi Angela , Cheon HeeJin , Teramo Antonella , Calabretto Giulia , Chahal Jasmanet , Vicenzetto Cristina , Almeida Julia , Shemo Bryna C. , Shi Min , Gasparini Vanessa Rebecca , Munoz-Garcia Noemi , Pastoret Cédric , Nakazawa Hideyuki , Oshimi Kazuo , Sokol Lubomir , Ishida Fumihiro , Lamy Thierry , Orfao Alberto , Morice William G. , Loughran Thomas P. , Semenzato Gianpietro , Zambello Renato 
Published: September 2022

AbstractTγδ large granular lymphocyte leukemia (LGLL) is a rare variant of T-cell LGLL (T-LGLL) that has been less investigated as compared with the more frequent Tαβ LGLL, particularly in terms of frequency of STAT3 and STAT5b mutations. In this study, we characterized the clinical and biological features of 137 patients affected by Tγδ LGLL; data were retrospectively collected from 1997 to 2020 at 8 referral centers. Neutropenia and anemia were the most relevant clinical features, being present in 54.2% and 49.6% of cases, respectively, including severe neutropenia and anemia in ∼20% of cases each. Among the various treatments, cyclosporine A was shown to provide the best response rates. DNA samples of 97 and 94 cases were available for STAT3 and STAT5b mutation analysis, with 38.1% and 4.2% of cases being mutated, respectively. Clinical and biological features of our series of Tγδ cases were also compared with a recently published Tαβ cohort including 129 cases. Though no differences in STAT3 and STAT5b mutational frequency were found, Tγδ cases more frequently presented with neutropenia (P = .0161), anemia (P &lt; .0001), severe anemia (P = .0065), and thrombocytopenia (P = .0187). Moreover, Vδ2− cases displayed higher frequency of symptomatic disease. Overall, Tγδ cases displayed reduced survival with respect to Tαβ cases (P = .0017). Although there was no difference in STAT3 mutation frequency, our results showed that Tγδ LGLL represents a subset of T-LGLL characterized by more frequent symptoms and reduced survival as compared with Tαβ LGLL.
The end of the beginning: application of single-cell sequencing to chronic lymphocytic leukemia
Authors: Nagler Adi , Wu Catherine J. 
Published: September 2022

Abstract
Single-cell analysis has emerged over the past decade as a transformative technology informative for the systematic analysis of complex cell populations such as in cancers and the tumor immune microenvironment. The methodologic and analytical advancements in this realm have evolved rapidly, scaling from but a few cells at its outset to the current capabilities of processing and analyzing hundreds of thousands of individual cells at a time. The types of profiling attainable at individual cell resolution now range from genetic and transcriptomic characterization and extend to epigenomic and spatial analysis. Additionally, the increasing ability to achieve multiomic integration of these data layers now yields ever richer insights into diverse molecular disease subtypes and the patterns of cellular circuitry on a per-cancer basis. Over the years, chronic lymphocytic leukemia (CLL) consistently has been at the forefront of genomic investigation, given the ready accessibility of pure leukemia cells and immune cells from circulating blood of patients with this disease. Herein, we review the recent forays into the application of single-cell analysis to CLL, which are already revealing a new understanding of the natural progression of CLL, the impact of novel therapies, and the interactions with coevolving nonmalignant immune cell populations. As we emerge from the end of the beginning of this technologic revolution, CLL stands poised to reap the benefits of single-cell analysis from the standpoints of uncovering fresh fundamental biological knowledge and of providing a path to devising regimens of personalized diagnosis, treatment, and monitoring.
EVI1 drives leukemogenesis through aberrant ERG activation
Authors: Schmoellerl Johannes , Barbosa Inês A.M. , Minnich Martina , Andersch Florian , Smeenk Leonie , Havermans Marije , Eder Thomas , Neumann Tobias , Jude Julian , Fellner Michaela , Ebert Anja , Steininger Monika , Delwel Ruud , Grebien Florian , Zuber Johannes 
Published: September 2022

Abstract
Chromosomal rearrangements involving the MDS1 and EVI1 complex locus (MECOM) on chromosome 3q26 define an aggressive subtype of acute myeloid leukemia (AML) that is associated with chemotherapy resistance and dismal prognosis. Established treatment regimens commonly fail in these patients, therefore, there is an urgent need for new therapeutic concepts that will require a better understanding of the molecular and cellular functions of the ecotropic viral integration site 1 (EVI1) oncogene. To characterize gene regulatory functions of EVI1 and associated dependencies in AML, we developed experimentally tractable human and murine disease models, investigated the transcriptional consequences of EVI1 withdrawal in vitro and in vivo, and performed the first genome-wide CRISPR screens in EVI1-dependent AML. By integrating conserved transcriptional targets with genetic dependency data, we identified and characterized the ETS transcription factor ERG as a direct transcriptional target of EVI1 that is aberrantly expressed and selectively required in both human and murine EVI1–driven AML. EVI1 controls the expression of ERG and occupies a conserved intragenic enhancer region in AML cell lines and samples from patients with primary AML. Suppression of ERG induces terminal differentiation of EVI1-driven AML cells, whereas ectopic expression of ERG abrogates their dependence on EVI1, indicating that the major oncogenic functions of EVI1 are mediated through aberrant transcriptional activation of ERG. Interfering with this regulatory axis may provide entry points for the development of rational targeted therapies.