bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of SARS-CoV-2 Infection With Serious Maternal Morbidity and Mortality From Obstetric Complications
Authors: Metz Torri D. , Clifton Rebecca G. , Hughes Brenna L. , Sandoval Grecio J. , Grobman William A. , Saade George R. , Manuck Tracy A. , Longo Monica , Sowles Amber , Clark Kelly , Simhan Hyagriv N. , Rouse Dwight J. , Mendez-Figueroa Hector , Gyamfi-Bannerman Cynthia , Bailit Jennifer L. , Costantine Maged M. , Sehdev Harish M. , Tita Alan T. N. , Macones George A. 
Published: July 2022

(Abstracted from JAMA 2022;327:748–759)
It is well known that pregnant individuals with COVID-19 have increased risks such as admission to the intensive care unit (ICU), mechanical ventilation, and death when compared with both nonpregnant adults with SARS-CoV-2 infection and pregnant adults without SARS-CoV-2 infection. However, although COVID-19 is known to increase the risk of maternal morbidity related to the virus, the possibility for higher risk of serious morbidity from obstetric complications is not clear.
Changing Patterns in Medication Prescription for Gestational Diabetes During a Time of Guideline Change in the USA: A Cross-Sectional Study
Authors: Venkatesh K. K. , Chiang C. W. , Castillo W. C. , Battarbee A. N. , Donneyong M. , Harper L. M. , Costantine M. , Saade G. , Werner E. F. , Boggess K. A. , Landon M. B. 
Published: July 2022

(Abstracted from BJOG 2022;129:473–483)
About a third of women with gestational diabetes mellitus (GDM) are unable to manage their condition with diet and exercise alone. Pharmacological management for GDM includes injectable insulin and oral agents, such as metformin and glyburide.
Interventions to Prevent Spontaneous Preterm Birth in Women With Singleton Pregnancy Who Are at High Risk: Systematic Review and Network Meta-analysis
Authors: Care Angharad , Nevitt Sarah J. , Medley Nancy , Donegan Sarah , Goodfellow Laura , Hampson Lynn , Smith Catrin Tudur , Alfirevic Zarko 
Published: July 2022

(Abstracted from BMJ 2022;376:e064547)
The leading cause of neonatal mortality are complications due to preterm birth. To manage the risk of preterm birth, the NICE (National Institute for Health and Care Excellence) recommends using vaginal progesterone or cervical cerclage.
Accuracy of Self-Assessment of Gestational Duration Among People Seeking Abortion
Authors: Ralph Lauren J. , Ehrenreich Katherine , Barar Rana , Biggs M. Antonia , Morris Natalie , Blanchard Kelly , Kapp Nathalie , Moayedi Ghazaleh , Perritt Jamila , Raymond Elizabeth G. , White Kari , Grossman Daniel 
Published: July 2022

(Abstracted from Am J Obstet Gynecol 2022;226:710.e1–710.e21)
Medication abortion using the 2-drug regimen of mifepristone and misoprostol is approved by the US Food and Drug Administration for women through 70 days' (or 10 weeks') gestation. Women at gestation duration (GD) longer than this are not eligible for medication abortion.
Development of a Simplified Patient-Centered Pelvic Floor Surgery Complication Scale
Authors: Fitzgerald Jocelyn , Richter Holly E. , Sung Vivian , Dunivan Gena , Mete Mihriye , Gutman Robert E. 
Published: July 2022

(Abstracted from Female Pelvic Med Reconstr Surg 2022;28:233–239)
Quality of life can be significantly impacted by pelvic floor disorders, including urinary incontinence, pelvic organ prolapse, and fecal incontinence. Although surgical procedures are often used to correct these conditions, inherent short-term and long-term complications do exist with these procedures.
Optimal Endometrial Thickness in Fresh and Frozen-Thaw In Vitro Fertilization Cycles: An Analysis of Live Birth Rates From 96,000 Autologous Embryo Transfers
Authors: Mahutte Neal , Hartman Michael , Meng Lynn , Lanes Andrea , Luo Zhong-Cheng , Liu Kimberly E. 
Published: July 2022

(Abstracted from Fertil Steril 2022;117:792–800)
A routine procedure of in vitro fertilization (IVF) cycles is to measure the endometrial thickness, as it has been determined that a measurement of <8 mm at human chorionic gonadotropin (HCG) trigger in fresh IVF–embryo transfer (IVF-ET) can increase the risk of ectopic pregnancy, spontaneous abortion, low birth weight, placenta previa, and other obstetric complications. In direct dichotomy to this, an endometrial thickness above 7 to 8 mm has a general association of improved IVF outcomes.
Regional analgesia for cardiac surgery
Authors: Grant Michael C. , Gregory Alexander J. , Ouanes Jean-Pierre P. 
Published: July 2022

Purpose of review
Regional anesthesia is gaining attention as a valuable component of multimodal, opioid-sparing analgesia in cardiac surgery, where improving the patient's quality of recovery while minimizing the harms of opioid administration are key points of emphasis in perioperative care. This review serves as an outline of recent advancements in a variety of applications of regional analgesia for cardiac surgery.

Recent findings
Growing interest in regional analgesia, particularly the use of newer “chest wall blocks”, has led to accumulating evidence for the efficacy of multiple regional techniques in cardiac surgery. These include a variety of technical approaches, with results consistently demonstrating optimized pain control and reduced opioid requirements. Regional and pain management experts have worked to derive consensus around nerve block nomenclature, which will be foundational to establish best practice, design and report future research consistently, improve medical education, and generally advance our knowledge in this vital area of perioperative patient care.

Summary
The field of regional analgesia for cardiac surgery has matured over the last several years. A variety of regional techniques have been described and shown to be efficacious as part of the multimodal, opioid-sparing approach to pain management in the cardiac surgical setting.
Regional versus general anesthesia for ambulatory total hip and knee arthroplasty
Authors: Baratta Jaime L. , Schwenk Eric S. 
Published: July 2022

Purpose of review
With the removal of both total knee and total hip arthroplasty from the Centers for Medicare and Medicaid Services’ inpatient-only list, efforts to improve efficiency of the perioperative management of total joint patients have increased recently. The publication of several recent studies examining the impact of anesthesia type on outcomes has prompted the need to review the overall state of evidence for spinal versus general anesthesia for outpatient total joint arthroplasty.

Recent findings
Overall complication rates are low in this carefully selected patient population. The majority of patients who are preselected for outpatient total joint arthroplasty appear to successfully achieve this outcome. Some retrospective studies have suggested a benefit for spinal anesthesia in terms of same-day discharge success but direct comparisons in prospective studies are lacking.

Summary
The type of anesthesia used for total joint arthroplasty may have an important effect on outcomes. Until randomized control trials are performed we must rely on existing evidence, which suggests that both spinal and general anesthesia can lead to successful outcomes after ambulatory total joint arthroplasty.
EBV-associated NK and T-cell lymphoid neoplasms
Authors: Kimura Hiroshi , de Leval Laurence , Cai Qingqing , Kim Won Seog 
Published: July 2022

Purpose of review
Epstein-Barr virus (EBV)-associated neoplasms derived from natural killer (NK) or T cells comprise a group of clinically and biologically heterogenous disorders affecting children and adults, which are overall rare but more prevalent in Asia and South America. This review focuses on neoplasms presenting in the adulthood, addressing recent genomic discoveries as well as therapeutic developments in these highly aggressive disorders.

Recent findings
Distinct molecular subtypes of extranodal NK/T-cell lymphomas (ENKTCLs) have been described, with differences in cell of origin, EBV pattern, genomic alterations, clinical characteristics, response to asparaginase-based therapies and to more recent approaches targeting molecular aberrations of the lymphoma. For the last two decades, progress in the clinical management of ENKTCL was based on L-asapraginase containing combinations and the incoroperation of radiotherapy. A subset of cases with PDL1-2 structural alterations may be more responsive to treatment with immune checkpoint inhibitors. Primary nodal EBV+ lymphomas derived from T or NK cells have distinctive features separating them from both peripheral T-cell lymphoma not otherwise specified and ENKTCL. Treatment algorithms correspond to those for advanced ENKTCL.

Summary
With better understanding of lymphomagenesis, genomic landscape and immunologic aspects of the diseases, future treatment options will include targeted therapies including immune checkpoint inhibitors and novel antibodies.
Local and systemic inflammation triggers different outcomes of tumor growth related to infiltration of anti-tumor or pro-tumor macrophages
Authors: Liu Xinghan , Jiang Qi , Shen Sunan , Hou Yayi 
Published: July 2022

Abstract

Background:
Previous evidence suggests inflammation may be a double-edged sword with cancer-promoting and cancer suppressing function. In this study, we explore the impact of local and systemic inflammation on cancer growth.

Methods:
Female BALB/C mice were subcutaneously implanted with foreign body (plastic plates) to build up a local inflammation and intraperitoneally injected with PolyIC or lipopolysaccharides (LPS) to build up a systemic inflammation, followed by subcutaneous injection of 5 × 105 colon cancer cells. Immunohistochemistry and enzyme linked immunosorbent assay were utilized to detect the Ki67 and interleukin (IL) 6, IL-1β, and monocyte chemoattractant protein-1 expression in the tumor tissues and serum, respectively. The distributions of immune cells and expression of toll-like receptors (TLRs) were evaluated by flow cytometry (FCM) and quantitative real time-polymerase chain reaction.

Results:
The results showed that local inflammation induced by foreign body implantation suppressed tumor growth with decreased tumor weight (P
= 0.001), volume (P
= 0.004) and Ki67 index (P
< 0.001). Compared with the control group, myeloid-derived suppressive cells sharply decreased (P
= 0.040), while CD4+ T cells slightly increased in the tumor tissues of the group of foreign body-induced local inflammation (P
= 0.035). Moreover, the number of M1 macrophages (P
= 0.040) and expression of TLRs, especially TLR3 (P < 0.001) and TLR4 (P < 0.001), were significantly up-regulated in the foreign body group. Contrarily, tumor growth was significantly promoted in LPS or PolyIC-induced systemic inflammation (P
= 0.009 and 0.006). FCM results showed M1 type macrophages (P
= 0.017 and 0.006) and CD8+ T cells (P
= 0.031 and 0.023) were decreased, while M2 type macrophages (P = 0.002 and 0.007) were significantly increased in tumor microenvironment of LPS or PolyIC-induced systemic inflammation group. In addition, the decreased expression of TLRs was detected in LPS or PolyIC group.

Conclusions:
The foreign body-induced local inflammation inhibited tumor growth, while LPS or PolyIC- induced systemic inflammation promoted tumor growth. The results suggested that the different outcomes of tumor growth might be attributed to the infiltration of anti-tumor or pro-tumor immune cells, especially M1 or M2 type macrophages into tumor microenvironment.
Robot-assisted laparoscopic partial nephrectomy: Contemporary results over a wide range of tumor complexity
Authors: Umbehr Martin H. , Jenni Simon , Fischer Boris , Zimmermann Matthias , Steigmiller Klaus , Müntener Michael 
Published: July 2022

Abstract

Background
Partial nephrectomy (PN) is considered the gold standard surgical treatment for renal masses < 7cm in size (T1 tumors). Since the introduction of the robotic-assisted laparoscopic PN (raPN) in high-volume centers, it has been increasingly adapted and standardized by urologists worldwide. There is growing evidence that the robot-assisted laparoscopic technique is associated with superior outcomes compared to those of open and conventional laparoscopic techniques. This study aimed to summarize the contemporary outcome data of raPN for renal tumors with varying degrees of complexity and to assess whether the outcomes reported from high-volume centers are reproducible in a limited caseload setting.

Materials and methods
This was a retrospective study of a single surgeon's experience, including 123 consecutive patients undergoing raPN at our institution. Ultimately, 110 patients were included in the analysis. Basic characteristics, tumor complexity as described by the RENAL score, complications described by the Clavien-Dindo classification system, and functional and oncological outcomes were assessed and analyzed statistically.

Results
Of the 110 patients, 27 (24%), 61 (55%), and 23 (21%) had low, intermediate, and high degrees of complexity, respectively, according to the RENAL score. A cancer-negative surgical margin was achieved in 108 (97%) patients. A total of 70 (64%) patients had no loss of renal function, while 20 (27%) had minimal loss of renal function. Complications of > 3 Clavien-Dindo classification during the first 30 postoperative days occurred in 5 (5%) patients. The 3 complexity groups were found to have significantly different ischemia time: Low, 8 minutes (interquartile range [IQR], 8–9.5); Intermediate, 12 minutes (IQR, 10–13); and High, 15.5 minutes (IQR, 11.25–18.75) (p < 0.001). There were no significant differences between the groups.

Conclusions
Contemporary standards for raPN are safe and reproducible. Adherence to the technique reported by centers of excellence yielded comparable results with regard to tumor control, preservation of renal function, and complication rates in lower-volume settings.
Evolution of Posttraumatic Symptoms and Related Factors in Healthcare Workers During the COVID-19 Pandemic
Authors: Rodríguez-Rey Rocío , Vega-Marín Verónica , Bueno-Guerra Nereida , Garrido-Hernansaiz Helena 
Published: July 2022

Objective
This study aimed to (1) evaluate the evolution of mental health (posttraumatic stress symptoms [PTSSs], depression, and burnout) of healthcare workers during the second wave of the pandemic (November to December 2020) and compare it with the first wave (March to May 2020), and (2) ascertain the predictors of PTSSs.

Methods
In March to May 2020 (T1), 269 healthcare professionals working in Spain completed PTSSs, sadness, resilience, and coping questionnaires. In November to December 2020 (T2, N = 58), we assessed PTSSs, sadness, burnout, and depression.

Results
Among the healthcare professionals, 63.8% displayed severe PTSSs, 51.7% depressive symptoms, and 79.3% emotional exhaustion (T2). Some risk factors were caring for patients who were severely ill or dying and using rumination, thinking avoidance, self-isolation, emotional expression, and self-blaming as coping strategies.

Conclusions
The pandemic has had a deep and long-lasting impact on the healthcare workers' mental health.
Estimating Absenteeism Related to Nonalcohol Substance Use in a US National Cohort of Full-Time Employees
Authors: Morgan Jake R. , Murphy Sean M. , Assoumou Sabrina A. , Linas Benjamin P. 
Published: July 2022

Objective
We aimed to estimate absenteeism due to substance use disorder among full-time employees.

Methods
We used the 2018 National Survey on Drug Use and Health to identify a sample of individuals employed full time. We used a survey-weighted multivariable negative binomial model to evaluate the association between absenteeism and type of substance use disorder controlling for available demographic information.

Results
In the adjusted model, we estimated that opioid use without a disorder had the highest absenteeism for use, and polysubstance use disorder had the highest absenteeism among use disorders. In a hypothetical firm of 10,000 employees, we estimate $232,000 of lost wage value annually.

Conclusions
Substance use is associated with absenteeism and presents a compelling argument for employers to promote programs that support treatment for employees and reduce downstream costs associated with absenteeism and turnover.
Sleep Quality and Mental Health Consequences of COVID-19 Pandemic in the Aviation Community in Greece
Authors: Karkala Aliki , Moschonas Stavros , Sykas Georgios , Karagianni Maria , Gilou Sotiria , Papaefthymiou Odysseas , Kourtidou-Papadeli Chrysoula 
Published: July 2022

ObjectiveThe aim of this study was to assess the mental health and sleep quality of aviation workers in Greece during the pandemic.MethodsA cross-sectional study of aviation workers in Greece was conducted.ResultsSleep disturbances were observed in 25.4% of our 548 participants, whereas 8.2% and 5.8% reported at least mild depressive and anxiety symptoms, respectively. The impact of the pandemic on their mental health was their primary concern, which increased for many active pilots according to their workload. Those infected mainly faced daily tiredness and fatigue. Smoking habits and high body mass index were a predisposition for more physical symptoms. Cabin crew and women generally yielded worse scores than the other groups.ConclusionFear of infection could explain mental health issues, whereas physical symptoms of those infected could be attributed to long-COVID (coronavirus disease) syndrome. Flight attendants' lower ratings may be due to more occupational exposure.
Firefighters With Higher Cardiorespiratory Fitness Demonstrate Lower Markers of Cardiovascular Disease Risk
Authors: McAllister Matthew J. , Gonzalez Drew E. , Leonard Megan , Martaindale M. Hunter , Bloomer Richard J. , Pence Jacquelyn , Martin Steven E. 
Published: July 2022

Objective
High cardiorespiratory fitness (CRF) is associated with reduced markers of oxidative stress and cardiovascular disease (CVD) risk factors; however, this relationship has not been elucidated in firefighters. The purpose of this study was to examine differences in markers of CVD risk between firefighters who have either high or low levels of CRF.

Methods
Forty-six firefighters participated in a maximal graded exercise test and a dual-energy x-ray absorptiometry scan and provided a fasted blood sample. V˙O2max values were categorized based on American College of Sports Medicine guidelines to establish high- and low-fitness groups.

Results
High fitness firefighters demonstrated significantly higher high-density lipoprotein cholesterol and lower markers of CVD risk: cholesterol, triglycerides, low-density lipoprotein cholesterol, insulin, homeostatic model assessment for insulin resistance, C-reactive protein, and advanced oxidation protein products concentrations.

Conclusion
Firefighters are encouraged to maintain high CRF to reduce risk of CVD.
Sickness Absence and Disability Pension in the Trade and Retail Industry
Authors: Farrants Kristin , Alexanderson Kristina 
Published: July 2022

Objective
This study aimed to investigate future sickness absence (SA) and disability pension (DP) among privately employed white-collar employees in the trade and retail industry.

Methods
A prospective population-based cohort study of all 192,077 such workers in Sweden in 2012, using linked microdata from nationwide registers, was conducted. Descriptive statistics of annual SA/DP during 2010 to 2016 and logistic regression for SA/DP in 2016 were used.

Results
Women had more mean SA/DP net days/person; however, there were no sex differences in the mean number of net days/person with SA/DP. The mean number of net days/person increased, especially with mental diagnoses. Sickness absence in 2012 was the strongest factor associated with SA/DP in 2016 (women: odds ratio, 3.28; 95% confidence interval, 3.09–3.47; men: odds ratio, 4.10; 95% confidence interval, 3.76–4.48). Work-related factors were weakly associated with future SA/DP.

Conclusions
The number of SA/DP net days per person increased, especially SA/DP days due to mental diagnoses.
Early Drug Prescription Patterns as Predictors of Final Workers Compensation Claim Costs and Closure
Authors: Tao Xuguang (Grant) , Lavin Robert A. , Yuspeh Larry , Tsourmas Nicholas F. , Kalia Nimisha , Leung Nina , Williams Leila , Hunt Dan L. , Green-McKenzie Judith , Bernacki Edward J. 
Published: July 2022

Objective
The aim of the study is to determine the associations of workers’ compensation claim costs and return to work with drugs prescribed for early symptom management.

Methods
Claims filed from 1998 to 2007 were followed for 10 years from the injury date. Drugs analyzed included gabapentin, pregabalin, antipsychotics, antidepressants, sedatives, benzodiazepines, carisoprodol, and opioids, controlling for initial reserve, sex, age, physical therapy, attorney involvement, and surgery.

Results
Gabapentin, antipsychotics, antidepressants, and sedatives used in the first 3 months after injury were significantly associated with higher claim cost (≥$100,000). All opioid morphine equivalent doses greater than or equal to 5 mg/d for the first 6 months was significantly associated with higher cost (≥$100,000) and not being released to work at end of third year after injury with dose-response relationships.

Conclusions
Prescription patterns in the first 3 months or first 6 months of workers’ compensation claim development may be used as predictors of claim outcomes.
Work-Related Stress and Occurrence of Cardiovascular Disease
Authors: Feng Meng-Yao , Wang Hui-Xin , Zhuo Lai-Bao , Yao Wu , Hao Chang-Fu , Pei Jin-Jing 
Published: July 2022

Objective
The aim of the study is to investigate the influence of work-related psychological and physical stresses on risk of cardiovascular disease (CVD).

Methods
A total of 5651 CVD-free participants older than 50 years from the Survey of Health, Ageing and Retirement in Europe were followed up for 13 years to detect incident CVD. Work-related stress was assessed using job strain and job reward questionnaire. Cox regression model was used to estimate the association.

Results
High physical demands (hazard ratio [HR], 1.30) and low reward (HR, 1.19) compared with their counterparts, as well as active physical jobs (HR, 1.41) and high physical strain (HR, 1.45) in comparison with low physical strain were associated with higher risk of incident CVD after adjusting for confounders. However, combining physically stressful jobs with low reward did not further increase the CVD risk.

Conclusions
Avoiding physically stressful jobs or providing appropriate reward may reduce the occurrence of CVD.