bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Higher Vocational Education and Training on the Development of Novice Teachers’ Skills: An Empirical Analysis
Authors: Jiahui Jin , (Retired) Prof. Salman Yousaf , Ahmad Prof. Nur Syakirah 
Published: August 2022

Abstract
This study was conducted to understand how higher vocational education and training affect the development of the skills and abilities of novice teachers in Dalian City, Liaoning Province, China. The Sample was collected from sixteen Dalian city vocational education and training institutes. Data was collected with the help of a questionnaire, and Statistical tests were applied to test the hypothesis and achieve the research objectives. It was concluded that Higher Vocational education and training significantly impact novice teachers' skill development in Dalian city, China. The quality of teaching and learning resources impact substantially on the development of novice teachers’ skills in Dalian City, China. The significant impact of teaching quality and curriculum on the skills development of novice teachers in Dalian City, China. There is a significant relationship between the quality of infrastructure provided by higher vocational education institutions and the skill development of novice teachers. Therefore, higher vocational education and training infrastructures have contributed to novice teachers' skills development in Dalian city, China.
Modified histopathological classification with age-related glomerulosclerosis for predicting kidney survival in ANCA-associated glomerulonephritis
Authors: Aydın Mehmet Fethullah , Yıldız Abdülmecit , Oruç Ayşegül , Vuruşkan Berna Aytaç , Akgür Suat , Ayar Yavuz , Güllülü Mustafa , Dilek Kamil , Yavuz Mahmut , Ortaç Hatice , Ersoy Alparslan 
Published: August 2022

Abstract
Background
The histopathological classification of ANCA-GN divides patients into four groups based on signs of glomerular injury. However, this classification did not consider age-related glomerulosclerosis. In this study, we aimed to compare the prediction of renal survival between Berden's ANCA-GN histopathological classification and ANCA-GN histopathological classification modified with age-related glomerulosclerosis.
Methods
Between January 2004 and December 2019, 65 patients diagnosed with ANCA-GN were enrolled. Demographic, laboratory, and histopathologic findings were retrospectively analyzed. Renal survival analyzes were compared according to classical and modified ANCA-GN histopathological classifications. The multivariate Cox regression analysis for the factors affecting renal survival was performed.
Results
In Berden's ANCA-GN histopathological classification, 15 patients were in the focal group, 21 in the crescentic, 21 in the sclerotic, and 8 in the mixed group. The ANCA-GN histopathological classification model generated statistically significant predictions for renal survival (p = 0.022). When the histopathological classification was modified with age-related glomerulosclerosis, 8 of the 9 patients previously classified in the sclerotic group were classified in the mixed and 1 in the crescentic groups. Modification of histopathological classification with age-related glomerulosclerosis increases the statistical significance in renal survival analysis (p = 0.009). The multivariate Cox regression analysis showed that the disease-related global sclerotic glomeruli percentage and serum creatinine level were the significant independent factors.
Conclusion
Modification of Berden's ANCA-GN histopathological classification model with age-related glomerulosclerosis may increase the statistical significance of the histopathological classification model.
Microbial and chemical risk from reclaimed water use for residential irrigation
Authors: Weidhaas Jennifer , Olsen McKinley , McLean Joan E. , Allen Niel , Ahmadi Leila , Duodu Kwame , Dupont Ryan 
Published: August 2022

AbstractArid and semi-arid locations are increasingly utilizing nontraditional irrigation water including reclaimed wastewater. Human health risk associated with reclaimed wastewater use was determined by testing reservoir, distribution line and home spigot water (n=190) and 14 types of vegetables and fruits (n=90) harvested from 5 home gardens for 7 waterborne pathogens, 47 antibiotic resistance genes and 12 pharmaceuticals and personal care products (PPCPs). Based on surveys of the residents’ use of the reclaimed wastewater, two exposure routes were modeled: irrigation of fruits and vegetables and drinking from irrigation hoses. Probabilistic quantitative microbial risk assessment indicated that consumption of raw vegetables and fruits exceeded a 0.015 benchmark illness rate due to adenovirus and enterococci. Chemical risk assessments indicated that consumption of tons of vegetables per day and hundreds to millions of gallons of water per day would be needed to reach an unacceptable risk among the 10 PPCPs detected in home spigot water, indicating de minimis risk from PPCPs. Eight different drug resistance gene families were detected in the water samples and crops indicating that antibiotic-resistant organisms are present on foods irrigated with reclaimed water containing pharmaceuticals. These results elucidate the combined risk from pathogens and PPCPs from reclaimed wastewater irrigation.
Automating process design by coupling genetic algorithms with commercial simulators: a case study for hybrid MABR processes
Authors: Yang Cheng , Belia Evangelia , Daigger Glen T. 
Published: August 2022

Abstract
The development of commercial software and simulators has progressed to assist engineers to optimize design, operation, and control of wastewater treatment processes. Commonly, manual trial-and-error approaches combined with engineering experience or exhaustive searches are used to find candidate solutions. These approaches are becoming less favorable because of the increasingly elaborate process models, especially for new and innovative processes whose process knowledge is not fully established. This study coupled genetic algorithms (GAs), a subfield of artificial intelligence (AI), with a commercial simulator (SUMO) to automatically complete a design task. The design objective was the upgrade of a conventional Modified Ludzack-Ettinger (MLE) process to a hybrid membrane aerated biofilm reactor (hybrid MABR). Results demonstrated that GAs can (1) accurately estimate five influent wastewater fractions using eleven typical measurements – 3 out of 5 estimated fractions were nearly the same and the other two were within 7% relative errors and (2) propose reasonable designs for the hybrid MABR process that reduce footprint by 17%, aeration by 57%, and pumping by 57% with significantly improved effluent nitrogen quality (TN&lt;3 mg-N/L). This study demonstrated that tools from AI promote efficiency in wastewater treatment process design, optimization and control by searching candidate solutions both smartly and automatically in replacement of manual trial-and-error methods. The methodology in this study contributes to accumulating process knowledge, understanding trade-offs between decisions, and finally accelerates the learning pace for new processes.
Isolation of Bacillus sp. with high laccase activity for green biodecolorization of synthetic textile dyes
Authors: Yang Jing , Xu Hao , Zhao Jian , Zhang Ning , Xie Jingcong , Jiang Jianchun 
Published: August 2022

Abstract
New Bacillus sp. strains with spore-laccase activity were isolated from rotten wood and soil samples and were identiﬁed as Bacillus sp. FM-78 and Bacillus paramycoides FM-86 by 16S rDNA gene sequence analysis. Both laccases were stable at broad pH range and high temperature. The laccase of strain FM-78 showed preferable activity and stability, with no loss of activity after 7 days incubation at pH 9.0, and 20.36% of its initial activity obtained after 10 h at 80 °C. 1 mmol/L EDTA, NaN3 and SDS resulted in about 46–59% inactivation and strongly inhibition (87.88%) was caused by 1 mmol/L L-cysteine. However, the spore laccase could tolerate towards 0.5 mol/L NaCl as well as 10% of organic solvents. Reactive black 5, reactive blue 19 and crystal violet were decolorized by the spore laccase in the absence of mediator. The decolorization process was efﬁciently promoted with the presence of acetosyringone, and the color removal ratio was more than 80% in 1 h with the pH values of 6.6 or 9.0. Finally, the above unusual properties of Bacillus sp. spore laccase indicated it as a potential candidate in the dye decolorization in an ecofriendly and cost-effective way.
Application of Nano-based Drug Loading Systems in the Treatment of Neurological
Infections: An Updated Review
Authors: Sadigh-Eteghad Saeed , Shahi Shahriar , Mahmoudi Javad , Farjami Afsaneh , Bazmani Ahad , Naghili Behrooz , Dizaj Solmaz Maleki , Salatin Sara 
Published: August 2022

Abstract:
Infection of the central nervous system (CNS) is a global healthcare concern with high rates of death
and disease. CNS infections mainly include meningitis, encephalitis, and brain abscesses. Bacteria, viruses,
fungi, protozoa, and parasites are the most common causes of neuroinfections. There are many types of medications
used in the treatment of CNS infections, but drug delivery through the blood-brain barrier (BBB) is a major
challenge to overcome. The BBB is a specialized multicellular barrier separating the neural tissue from the
peripheral blood circulation. Unique characteristics of the BBB allow it to tightly control the movement of ions
and molecules. Thus, there is a critical need to deal with these conditions with the aim of improving novel antimicrobial
agents. Researchers are still struggling to find effective drugs to treat CNS infections. Nanoparticle
(NP)-mediated drug delivery has been considered a profound substitute to solve this problem because NPs can
be tailored to facilitate drug transport across the BBB. NPs are colloidal systems with a size range of 1-1000
nm, which can be used to encapsulate therapeutics, improve drug transport across the BBB, and target specific
brain areas in CNS infections. A wide variety of NPs has been displayed for the CNS delivery of therapeutics,
especially when their surfaces are coated with targeting moieties. This study aimed to review the available literature
on the application of NPs in CNS infections.
Narrative on Hydrogen Therapy and its Clinical Applications: Safety and Efficacy
Authors: Ahmad Aqeel , Baig Atif Amin , Hussain Mubashir , Saeed Muhammad Usama , Bilal Muhammad , Ahmed Naveed , Chopra Hitesh , Hassan Muhammad , Rachamalla Mahesh , Putnala Sravan Kumar , Khaliq Muniba , Tahir Zirwah , Kamal Mohammad Amjad 
Published: August 2022

Abstract:
Molecular hydrogen proved itself as a novel therapeutic candidate and has been thriving from the beginning with its potential clinical significance, higher affinity, and cellular integrity and permeability. Hydrogen Therapy (HT) has gained scientists' attention with the proven clinical ability to attenuate chronic inflammation, diminish oxidative stress, restrict apoptosis, minimize cellular injury, and refine tissue functioning. Therapeutic Implementation of H2 for disease prevention and treatment is a newly emerging field with limited knowledge available on formulations, tissue-specific effects, efficacy, and safety. This article will discuss HT's therapeutic potential for its efficacy and safety in cardiovascular, respiratory, hematological, metabolic, infectious, and neurodegenerative disorders. In addition to this, the molecular mechanisms and nanotechnological implications of hydrogen therapy will be discussed in detail. Finally, the article will provide insight into advancements and automation, future perspectives, and recommendations. There is a need to study and conduct higher-scale trials targeting personalized treatments under molecular and genetic vitals.
COVID-19: Pathophysiology, Transmission, and Drug Development for Therapeutic
Treatment and Vaccination Strategies
Authors: Singh Vishal Kumar , Chaurasia Himani , Mishra Richa , Srivastava Ritika , Yadav Aditya K. , Dwivedi Jayati , Singh Prashant , Singh Ramendra K. 
Published: August 2022

Abstract:
COVID-19, a dreaded and highly contagious pandemic, is flagrantly known for its rapid prevalence across the world. Till date, none of the treatments are distinctly accessible for this life-threatening disease. Under the prevailing conditions of medical emergency, one creative strategy for the identification of novel and potential antiviral agents gaining momentum in research institutions and progressively being leveraged by pharmaceutical companies is target-based drug repositioning/repurposing. A continuous monitoring and recording of results offer an anticipation that this strategy may help to reveal new medications for viral infections. This review recapitulates the neoteric illation of COVID-19, its genomic dispensation, molecular evolution via phylogenetic assessment, drug targets, the most frequently worldwide used repurposed drugs and their therapeutic applications, and a recent update on vaccine management strategies. The available data from solidarity trials exposed that the treatment with several known drugs, viz. lopinavir-ritonavir, chloroquine, hydroxychloroquine, etc had displayed various antagonistic effects along with no impactful result in diminution of mortality rate. The drugs like remdesivir, favipiravir, and ribavirin proved to be quite safer therapeutic options for treatment against COVID-19. Similarly, dexamethasone, convalescent plasma therapy and oral administration of 2DG are expected to reduce the mortality rate of COVID-19 patients
A Novel Idea of Sulfamic Acid as an Efficient Catalyst for the Synthesis of
2-Azapyrrolizidine Derivatives
Authors: Tafer Radia , Boulcina Raouf , Debache Abdelmadjid 
Published: August 2022

Background:
The synthesis of 2-azapyrrolizidine scaffolds has fascinated scientists due to their potential biological activities.

Objective:
An efficient and environmentally sustainable synthetic method has been presented to synthesize structurally various 2-azapyrrolizidines via three-component reaction.

Methods:
The condensation of aldehydes, hydantoin, and malononitrile in the presence of green and sustainable sulfamic acid as catalyst in mild conditions has been achieved.

Results:
The present protocol leads in most cases to the desired products in high yields.

Conclusion:
The synthetic efficiency and operational simplicity make the present procedure cost effective, time efficient and eco-friendly for the synthesis of substituted 2-azapyrrolizidines.
Strongyloides sp. resistentes al albendazol y levamisol en búfalos de México
Authors: Ojeda-Robertos Nadia Florencia , Aguirre-Serrano Atziri Miroshlava , Cardenas de la Cruz Rosina , Hernández-Martínez Liss Nayelli , Peralta-Torres Jorge Alonso , Chay-Canul Alfonso Juventino , Priego-García Jorge Alberto , Riodríguez-Vivas Roger Ivan 
Published: August 2022

Objetivo. Se evaluó la eficacia antihelmítica de albendazol y levamisol sobre poblaciones de Strongyloides sp. en bucerros (Bubalus bubalis) con infecciones naturales en el trópico Mexicano. Materiales y Métodos. Se incluyeron 45 bucerros, que fueron distribuidos en tres grupos experimentales de acuerdo a la excreción de huevos por gramo de heces (HPG) de Strongyloides sp. (n=15): a) Grupo control: sin desparasitación, b) Grupo BZ (benzimidazoles) que recibó albendazol a razón de 10 mg/kg vía oral, y c) Grupo IMIDA (imidaziotazoles) dosificación de levamisol a razón de 8 mg/kg vía subcutánea. Para determinar los HPG de cada animal, se obtuvieron heces directamente del recto los días 0 (Pre-T) y 10 (PT). Las muestras fueron procesadas mediante la técnica de McMaster y los resultados de HPG se analizaron mediante el programa RESO para conocer el porcentaje de reducción de huevos y sus intervalos de confianza al 95% (IC95%). Resultados. El grupo BZ registró un 94% de reducción de HPG (IC95%= 87–97) y el grupo IMIDA registró 95% de reducción en el HPG (IC95%= 84-99). Conclusión. Se reporta por primera vez en México la presencia de poblaciones de Strongyloides sp. resistentes a benzimidazoles e imidazotiazoles en bucerros del trópico mexicano infectados naturalmente.
Evaluación in vitro de cinco ixodicidas contra Rhipicephalus microplus en Catacamas, Olancho, Honduras
Authors: Lepe López Manuel Antonio , Brizo-Murillo Josselyn Maryeri 
Published: August 2022

Objetivo. El presente estudio tiene por objetivo evaluar la eficacia in vitro de cinco productos comerciales empleados en el sitio con mayor producción de bovinos en Honduras. Materiales y métodos. Se colectaron garrapatas en cuatro fincas ganaderas en Catacamas (14°50' N, 85°53' S), considerando una cantidad de 300 bovinos. Se colectaron aproximadamente 1,000 teleóginas de R. microplus para implementar un grupo control y cinco grupos de comparación, cada grupo incluyó dos replicas con 50 individuos. Se realizó el método de inmersión con cada uno de los cinco productos comerciales y se estimaron las siguientes tasas: mortalidad, ovoposición, eclosión, eficiencia reproductiva y eficacia del producto según lo propuesto por Drummond et al., 1973. Resultados. Cuatro de los productos comerciales con los siguientes ingredientes activos (Producto 1: cipermetrina, clorpirifós, butóxido de piperonilo. Producto 2: cipermetrina, ethion, butóxido de piperonilo. Producto 3: amitraz. Producto 4: coumaphos), obtuvieron una eficacia superior al 90%, sobresaliendo las familias químicas de amidinas, organofosforados y la combinación de organofosforados con piretroides para el control de R. microplus en la localidad de Catacamas, Honduras. Por otra parte, un producto (Producto 5: cipermetrina), presenta una eficacia del 68%. Este producto de la familia de los piretroides muestra problemas de eficacia con mortalidad del 33% y los individuos sobrevivientes presentan una tasa reproductiva del 30%. Conclusiones. Es necesario modificar el uso de la cipermetrina en Catacamas, Honduras, incorporando un control integral de parásitos para reducir la posibilidad de resistencia antiparasitaria de R. microplus.
Mindfulness-Based Smoking Cessation Delivered Through Telehealth and Text Messaging for Low-Income Smokers: Protocol for a Randomized Controlled Trial
Authors: Spears Claire A , Mhende Josephine , Hawkins China , Do Vuong Van , Hayat Matthew J , Eriksen Michael P , Hedeker Donald , Abroms Lorien C , Wetter David W 
Published: August 2022

BackgroundTobacco use is the leading cause of preventable morbidity and mortality. Adults with low income and members of certain racial and ethnic minority groups are less likely to quit, and therefore, they experience profound tobacco-related health disparities. Mindfulness training can increase the rates of smoking cessation and lapse recovery, and telehealth and SMS text messaging have the potential to provide more accessible treatment.ObjectiveThis study aims to test the efficacy of delivering mindfulness-based smoking cessation treatment through text messaging (iQuit Mindfully) and telehealth (group videoconferencing), both as stand-alone interventions and in combination. In addition, it aims to examine the underlying mechanisms of mindfulness treatment.MethodsIn this 2×2 randomized controlled trial, participants are randomized into 1 of 4 groups based on assignment to iQuit Mindfully text messages (yes or no) and mindfulness videoconference groups (yes or no). The primary outcomes are biochemically verified smoking abstinence at 8, 12, and 24 weeks after the start of treatment. Secondary outcomes include the frequency of home mindfulness practice and self-reported levels of mindfulness, emotions, craving, withdrawal, dependence, self-efficacy, and social support.ResultsRecruitment, treatment, and assessment began in spring and summer 2021, and data collection is expected to continue through spring 2024.ConclusionsThis project aims to improve smoking cessation outcomes for low-income, racially and ethnically diverse smokers through mindfulness-based telehealth group counseling and text messaging support. We also aim to advance the scientific study of the mechanisms of action of mindfulness treatment, which could inform the development of more efficacious and efficient treatments to reduce tobacco disparities.Trial RegistrationClinicaltrials.gov NCT04965181; https://clinicaltrials.gov/ct2/show/NCT04965181International Registered Report Identifier (IRRID)PRR1-10.2196/35688
Intervensi Keperawatan dalam Meningkatkan Quality of Life (QoL) Pasien dengan Kanker: Studi Literatur
Authors: Hardiyani Tati , Wahyuni Sri , Ramadhan Muhammad Deri , Effendy Christantie 
Published: August 2022

Background: The cancer prevalance is predicted to raise. Cancer affects patient's quality of life, such as psychological, sexual, social function, and daily activities. The appropriate nursing interventions are needed for each type of cancer to improve nursing outcomes and quality of life.Objective: To identify the types of nursing intervention that could improve the quality of life of patients with cancer.Method: Four electronic databases, such as PubMed, Sciencedirect, Ebsco-host, and Clinical-Key, were explored to find original research articles which focused on the types of nursing intervention in caring for patients with cancer. Fourteen articles were included in the study, and each of article was analyzed using The Joanna Briggs Institute (JBI) Appraisal tool to achieve the purpose of the study.Results: The study found that psychological nursing interventions, physical nursing intervention including exercise/physical activity, and technology application in nursing intervention were contributed significantly to enhance patients’ quality of life.Conclusions: Nursing interventions which are psychological, physical, and using technology application can improve the quality of life of patients with cancer significantly. ABSTRAKLatar belakang: Angka kejadian kanker diprediksi semakin meningkat. Pasien kanker akan mengalami perubahan efek psikologi, seksual, fungsi sosial serta aktivitas keseharian yang memengaruhi Quality of Life pasien. Diperlukan intervensi keperawatan yang tepat sesuai jenis kanker untuk meningkatkan Quality of Life pasien kanker.Tujuan: Studi ini bertujuan untuk mengidentifikasi jenis intervensi keperawatan dalam meningkatkan quality of life pasien kanker.Metode: Pencarian literatur dilakukan untuk mendapatkan artikel berupa original research pada 4 database yaitu PubMed, Sciencedirect, Ebsco-host, Clinical-Key. Didapatkan sebanyak 14 artikel yang mengukur quality of life pasien kanker sesuai kriteria inklusi. Setiap artikel dilakukan analisis menggunakan The Joanna Briggs Institute (JBI) Appraisal tool untuk mencapai tujuan penelitian.Hasil: Penelitian ini menemukan bahwa intervensi keperawatan psikologis, intervensi keperawatan fisik berupa exercise/physical activity, dan intervensi keperawatan dengan aplikasi teknologi memberikan kontribusi pada kualitas hidup pasien kanker. Semua intervensi keperawatan tersebut secara statistik dapat meningkatkan Quality of Life pada pasien kanker. Kesimpulan: Intervensi keperawatan yang berupa psikologis, fisik dan menggunakan aplikasi teknologi terbukti dapat meningkatkan quality of life pasien kanker secara signifikan.
Memoria, Trauma y Trabajo de Elaboración
Authors: Arrubla-Sánchez Ricardo , Zuluaga María Del Pilar 
Published: August 2022

El artículo realiza un análisis de los documentos de memoria producidos durante el 2008 hasta el 2019, para caracterizar sus aspectos centrales y compararlos con relación al uso de las categorías de dolor, daño e imaginación en las víctimas. Metodología: es una investigación hermenéutica de tipo cualitativo con análisis de contenido, aplicada a una muestra de 45 documentos. Resultados: la investigación permitió establecer que el mayor porcentaje de relaciones temáticas se relaciona con 11% masacre paramilitar, 6% verdad y memoria, 2% Duelo, memoria y reparación. Conclusiones: Los trabajos de elaboración de memoria traumática y del conflicto en Colombia, han desconocido aspectos fundamentales con relación al daño, el dolor y la imaginación, siendo estos partes constitutivos de la memoria de las víctimas.