bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vulcanimicrobium alpinus gen. nov. sp. nov., the first cultivated representative of the candidate phylum “Eremiobacterota”, is a metabolically versatile aerobic anoxygenic phototroph
Authors: Yabe Shuhei , Muto Kiyoaki , Abe Keietsu , Yokota Akira , Staudigel Hubert , Tebo Bradley M 
Published: December 2022

Abstract
The previously uncultured phylum “Candidatus Eremiobacterota” is globally distributed and often abundant in oligotrophic environments. Although it includes lineages with the genetic potential for photosynthesis, one of the most important metabolic pathways on Earth, the absence of pure cultures has limited further insights into its ecological and physiological traits. We report the first successful isolation of a “Ca. Eremiobacterota” strain from a fumarolic ice cave on Mt. Erebus volcano (Antarctica). Polyphasic analysis revealed that this organism is an aerobic anoxygenic photoheterotrophic bacterium with a unique lifestyle, including bacteriochlorophyll a production, CO2 fixation, a high CO2 requirement, and phototactic motility using type IV-pili, all of which are highly adapted to polar and fumarolic environments. The cells are rods or filaments with a vesicular type intracytoplasmic membrane system. The genome encodes novel anoxygenic Type II photochemical reaction centers and bacteriochlorophyll synthesis proteins, forming a deeply branched monophyletic clade distinct from known phototrophs. The first cultured strain of the eighth phototrophic bacterial phylum which we name Vulcanimicrobium alpinus gen. nov., sp. nov. advances our understanding of ecology and evolution of photosynthesis.
Metal-free FRET macrocycles of perylenediimide and aza-BODIPY for multifunctional sensing
Authors: Rani Kavita , Sengupta Sanchita 
Published: December 2022

Multichromophoric metal-free FRET macrocycles M1 [1+1] and M2 [2+2] composed of PDI and ABDP have been synthesized and showed distinct stimuli responsiveness towards temperature and redox potential variation.
Dysregulated haemostasis in thrombo-inflammatory disease
Authors: Klavina Paula A. , Leon Gemma , Curtis Annie M. , Preston Roger J.S. 
Published: December 2022

Abstract
Inflammatory disease is often associated with an increased incidence of venous thromboembolism in affected patients, although in most instances, the mechanistic basis for this increased thrombogenicity remains poorly understood. Acute infection, as exemplified by sepsis, malaria and most recently, COVID-19, drives ‘immunothrombosis’, where the immune defence response to capture and neutralise invading pathogens causes concurrent activation of deleterious prothrombotic cellular and biological responses. Moreover, dysregulated innate and adaptive immune responses in patients with chronic inflammatory conditions, such as inflammatory bowel disease, allergies, and neurodegenerative disorders, are now recognised to occur in parallel with activation of coagulation. In this review, we describe the detailed cellular and biochemical mechanisms that cause inflammation-driven haemostatic dysregulation, including aberrant contact pathway activation, increased tissue factor activity and release, innate immune cell activation and programmed cell death, and T cell-mediated changes in thrombus resolution. In addition, we consider how lifestyle changes increasingly associated with modern life, such as circadian rhythm disruption, chronic stress and old age, are increasingly implicated in unbalancing haemostasis. Finally, we describe the emergence of potential therapies with broad-ranging immunothrombotic functions, and how drug development in this area is challenged by our nascent understanding of the key molecular and cellular parameters that control the shared nodes of proinflammatory and procoagulant pathways. Despite the increasing recognition and understanding of the prothrombotic nature of inflammatory disease, significant challenges remain in effectively managing affected patients, and new therapeutic approaches to curtail the key pathogenic steps in immune response-driven thrombosis are urgently required.
Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid–liquid phase separation
Authors: Wu Si , Wen Jitao , Perrett Sarah 
Published: December 2022

Abstract
Biomolecular condensate formation via liquid–liquid phase separation (LLPS) has emerged as a ubiquitous mechanism underlying the spatiotemporal organization of biomolecules in the cell. These membraneless condensates form and disperse dynamically in response to environmental stimuli. Growing evidence indicates that the liquid-like condensates not only play functional physiological roles but are also implicated in a wide range of human diseases. As a major component of biomolecular condensates, intrinsically disordered proteins (IDPs) are intimately involved in the LLPS process. During the last decade, great efforts have been made on the macroscopic characterization of the physicochemical properties and biological functions of liquid condensates both in vitro and in the cellular context. However, characterization of the conformations and interactions at the molecular level within phase-separated condensates is still at an early stage. In the present review, we summarize recent biophysical studies investigating the intramolecular conformational changes of IDPs upon LLPS and the intermolecular clustering of proteins undergoing LLPS, with a particular focus on single-molecule fluorescence detection. We also discuss how these microscopic features are linked to the macroscopic phase transitions that are relevant to the physiological and pathological roles of the condensates.
Retracted: Using Markov predictions for handling and allocating task to virtual machines in clouds data centres
Authors: Zavieh Hadi , Javadpour Amir , Li Yuan , Ja'fari Forough , Sangaiah Arun Kumar , Zhang Weizhe , Nasseri Seyed Hadi 
Published: December 2022

AbstractThe above article from IET Communications, published online on 16 December 2022 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Interim Editor‐in‐Chief, Jian Ren, the Institution of Engineering and Technology (the IET) and John Wiley and Sons Ltd. This article was published as part of a Guest Edited special issue. Following an investigation, the IET and the journal have determined that the article was not reviewed in line with the journal's peer review standards and there is evidence that the peer review process of the special issue underwent systematic manipulation. Accordingly, we cannot vouch for the integrity or reliability of the content. As such we have taken the decision to retract the article. The authors have been informed of the decision to retract.
Prediction of chlorophyll‐a data based on triple‐stage attention recurrent neural network
Authors: Chang Wenqing , Li Xiang , Chaudhary Vikas , Dong Huomin , Zhao Zhigang , Nguyen Tri Gia 
Published: December 2022

AbstractMarine Internet of Things (IOT) is the use of Internet technology to connect various sensing devices at sea, so as to integrate maritime information and realize the monitoring and systematic management of complex data at sea. The marine environment is complex and changeable, and marine disasters occur frequently, such as red tides. Due to the sudden and destructive nature of red tide, it plays a pivotal role to monitor the occurrence of the red tide for the marine IoT, where machine learning has been widely used to predict red tides. However, they were rarely able to catch the sudden change of chlorophyll‐a, which has important practical significance for predicting the occurrence of red tide. In order to deal with the above problems, this paper proposes the triple‐stage attention‐based recurrent neural network, which can enhance the representation ability of input sequences, selectively capture dynamic spatial correlations between input multi‐channel observations in the input sequence, meanwhile adaptively capturing dynamic temporal correlations between different time intervals in the input sequence. The results show that this method outperforms the state‐of‐art baseline methods here.
A fault prediction framework for Doubly‐fed induction generator under time‐varying operating conditions driven by digital twin
Authors: Ma Junyan , Yuan Yiping , Chen Pan 
Published: December 2022

AbstractAccurate status prediction is critical for detecting potential failures of Doubly‐fed induction generator (DFIG). A unique Digital Twin (DT) fault prediction paradigm is put forth in this research, which uses an edge intelligence paradigm to ensure high‐performance fault prediction. Edge‐based DT provides compute and storage capabilities on edge devices to enable effective data processing. The stator current spectrum and instantaneous power spectrum of the DFIG are simulated and assessed, followed by the development of a verification prototype on the DFIG and the qualitative observation of the internal performance of the DFIG. The encoder is constructed using Squeeze‐and‐Excitation (SE) Convolutional Neural Network (SE‐CNN) with the channel attention mechanism, and the decoder is constructed based on a long short‐term memory (LSTM) network to form the self‐encoding model named SE‐CNN‐LSTM. In order to forecast problems and provide a foundation for predictive maintenance, the status indicator is built based on the prediction residuals of the status variables. Based on the outcomes of edge‐cloud co‐simulation and data collected from the Supervisory Control and Data Acquisition system at the Da Bancheng Wind Farm in Xinjiang, China, it is demonstrated that the framework and technology are workable and capable of predicting generator failures.
Distributed optimal dispatching method of smart distribution network considering integrated energy microgrid with multiple gird‐connected points
Authors: Sun Bing , Jing Ruipeng , Zeng Yuan , Ge Leijiao , Liang Gang , Dong Shimeng 
Published: December 2022

AbstractThe interactive demand of electrical power between integrated energy microgrid (IEMG) and smart distribution network (SDN) is growing rapidly with the increase of distributed generation (DG) installed capacity. When SDN and IEMG are connected through a single gird‐connected point, the renewable power consumption may be limited by tie‐line capacity. A distributed optimal dispatching method of the SDN considering the IEMG with multiple gird‐connected points is proposed. The impact of various flexible resources is also considered. Firstly, a IEMG connection mode, in which each IEMG can be connected to multiple nodes of the SDN, is designed. A distributed optimal dispatching method is proposed, by which the IEMG operation privacy and the SDN responsibility to consume renewable power can be considered. Then, the electric power on tie‐lines is taken as the coupling variable to establish the IEMG and SDN coordinated dispatching model. The model can be solved by adjusting the power upper limits of tie‐lines circularly. Finally, the improved IEEE 33‐bus system is analysed based on the proposed method. It is found that when the IEMG is with large DG installed capacity, multiple gird‐connected points can improve the SDN operation flexibility and increase the operation benefits of all entities.
Communication‐free decentralized power flow control of unified power flow controllers and phase‐shifting transformers in high voltage transmission systems
Authors: Choudhury Soham , Saçiak Andreas , Hanson Jutta 
Published: December 2022

AbstractConventional phase‐shifting transformers (PST) have been utilized for power flow control in transmission networks for many years. Compared to the slow reacting PSTs, recently trending unified power flow controllers (UPFC) enable much faster power flow control. This paper introduces a decentralized power flow control scheme for power flow controllers (PFCs) without the need for communication between the PFCs. For each PFC, an influence area is defined. The line loading of the transmission lines in this influence area is monitored in real‐time operation and if there is an overloading of a line, a feedback control scheme is used to mitigate the overloading of the line. As the power flow control of UPFC is dependent of the network topology and the UPFC converter limit, additional control measures are introduced to circumvent potential critical scenarios. Supplementary control measures are also developed to increase the robustness of control scheme for the simultaneous operation of UPFC with slow reacting PST. Using RMS simulation in DIgSILENT PowerFactory, the developed control method is validated in the IEEE 68‐Bus NETS/NYPS test bench network. The method is also validated for UPFCs with overlapping influence areas and the combination of fast acting UPFCs and slow acting PST devices.
Investigating the vertical distribution of the disk as a function of radial action
Authors: Jia Yunpeng , Chen Yuqin , Du Cuihua , Zhao Gang 
Published: December 2022

Aims. As heating processes can broaden the distributions of radial actions and the vertical distributions of the Galactic disks, we investigate the vertical distribution of the Galactic disks as a function of radial action based on Apache Point Observatory Galactic Evolution Experiment (APOGEE) and Gaia data in order to deepen our understanding of the formation and heating history of the Galactic disks.
Methods. The vertical distributions of the thin and thick Galactic disks defined in the chemical plane were fitted with a simple exponential function with a free parameter of scale height in different radial action ranges. Therefore, we were able to analyze the scale height as a function of radial action for different disk populations.
Results. We find that the distributions of radial action for both the thin and thick disks can be approximately described by pseudo-isothermal distributions, which give a statistical measurement for the temperature of the disk as indicated by the mean radial action of the star sample. Estimations of the scale heights in different radial action ranges for these pseudo-isothermal distributions of the disks seem to show fixed relationships between radial action JR and scale height h. We describe these relationships with a two-parameter function of h = √(JR/a)+b, where a and b are free parameters. When testing with a three-parameter function of h = α√(JR/a)+b, we find that this two-parameter function describes the thin disk well, but we note the function should be used with care for the thick disk. When comparing the best-fit relationships between the inner and outer disk for both of the thin and thick disks, we find that the relationships are nearly the same for the thin disks but are different for the thick disks. The inner thick disk shows a nearly flattened relationship, while the outer thick disk presents a gradually increasing relationship. This work highlights an alternative way to unveil the heating history of the disks by investigating the relationship between scale height and radial action, as these relationships encode the formation and heating history of the Galactic disks.
Linking the dust and chemical evolution: Taurus and Perseus
Authors: Navarro-Almaida D. , Bop C. T. , Lique F. , Esplugues G. , Rodríguez-Baras M. , Kramer C. , Romero C. E. , Fuente A. , Caselli P. , Rivière-Marichalar P. , Kirk J. M. , Chacón-Tanarro A. , Roueff E. , Mroczkowski T. , Bhandarkar T. , Devlin M. , Dicker S. , Lowe I. , Mason B. , Sarazin C. L. , Sievers J. 
Published: December 2022

Context. HCN, HNC, and their isotopologues are ubiquitous molecules that can serve as chemical thermometers and evolutionary tracers to characterize star-forming regions. Despite their importance in carrying information that is vital to studies of the chemistry and evolution of star-forming regions, the collision rates of some of these molecules have not been available for rigorous studies in the past.
Aims. Our goal is to perform an up-to-date gas and dust chemical characterization of two different star-forming regions, TMC 1-C and NGC 1333-C7, using new collisional rates of HCN, HNC, and their isotopologues. We investigated the possible effects of the environment and stellar feedback in their chemistry and their evolution.
Methods. We used updated collisional rates of HCN, HNC, and their isotopologues in our analysis of the chemistry of TMC 1-C (Taurus) and NGC 1333-C7 (Perseus). With millimeter observations, we derived their column densities, the C and N isotopic fractions, the isomeric ratios, and the deuterium fractionation. The continuum data at 3 mm and 850 µm allowed us to compute the emissivity spectral index and look for grain growth as an evolutionary tracer.
Results. The H13CN/HN13C ratio is anticorrelated with the deuterium fraction of HCN, thus it can readily serve as a proxy for the temperature. The spectral index (β ~ 1.34–2.09) shows a tentative anticorrelation with the H13CN/HN13C ratio, suggesting grain growth in the evolved, hotter, and less deuterated sources. Unlike TMC 1-C, the south-to-north gradient in dust temperature and spectral index observed in NGC 1333-C7 suggests feedback from the main NGC 1333 cloud.
Conclusions. With this up-to-date characterization of two star-forming regions, we found that the chemistry and the physical properties are tightly related. The dust temperature, deuterium fraction, and the spectral index are complementary evolutionary tracers. The large-scale environmental factors may dominate the chemistry and evolution in clustered star-forming regions.
Operative Korrektur der Beinachse bei X-chromosomaler
Hypophosphatämie
Authors: Mindler Gabriel T. , Ganger Rudolf , Stauffer Alexandra , Raimann Adalbert , Kocijan Roland , Radler Christof 
Published: December 2022

ZusammenfassungDie X-chromosomale Hypophosphatämie (XLH, OMIM 307800) ist eine seltene
Knochenerkrankung, die durch Mutationen in PHEX (PHEX phosphate regulating
endopeptidase X-linked) verursacht wird. Rachitis, Osteomalazie, Kleinwuchs und
komplexe Beindeformitäten gehören zu den wichtigsten skelettalen
Veränderungen dieser Erkrankung. Die konservative Therapie mit
Phosphatsalzen oder FGF23-hemmenden Antikörpern kann Beschwerden
nachweislich verbessern. Dennoch zeigen rezente Studien eindrücklich das
Ausmaß der Krankheitstypischen Gangveränderungen,
Beindeformitäten und damit einhergehenden Verminderung der
Lebensqualität. Ein bedeutendes orthopädisches Behandlungsziel
an der unteren Extremität ist der Erhalt bzw. die Herstellung
physiologischer Beinachsenstellung. Dieser Artikel fasst die
orthopädische Therapie von Beindeformitäten bei Kindern und
Erwachsenen mit XLH in einem multidisziplinären Setting zusammen.
Bromine-Radical-Mediated Bromoallylation of C–C Unsaturated Bonds: A Facile Access to 1,4-, 1,5-, 1,6-, and 1,7-Dienes and Related Compounds
Authors: Ryu Ilhyong , Sumino Shuhei 
Published: December 2022

AbstractThe radical bromoallylation of alkynes, allenes, and vinylidene cyclopropanes proceeds efficiently in the presence of a radical initiator to give 2-bromo-substituted 1,4-, 1,5-, and 1,6-diene derivatives, respectively. Three-component reactions comprised of allenes, electron-deficient alkenes, and allyl bromides give 1,7-dienes in good yields. The bromoallylation of an arylalkene can override β-scission of the bromine radical from β-bromoalkyl radicals to give 5-bromoalkenes, whilst the bromoallylation of vinylcyclopropanes is accompanied by 5-exo ring closure to give 1-(bromomethyl)-2-vinylcyclopentane derivatives in good yields. All of the products contain a reactive vinyl bromide moiety, which can be readily functionalized by Pd-catalyzed cross-coupling and radical cascade reactions.1	Introduction2	Synthesis of 1,4-Dienes by Bromoallylation of Acetylenes3	Synthesis of 1,5-Dienes by Bromoallylation of Allenes4	Synthesis of 1,6-Dienes by Bromoallylation of Methylenecyclopropanes5	Synthesis of 1,7-Dienes by Bromoallylation of Allenes and Electron-Deficient Alkenes6	Bromoallylation of Arylalkenes and Vinylcyclopropanes7	Conclusion
Microwave-Assisted Domino Povarov-Type [4+2] Cycloaddition: A Rapid Access to 7-Phenyl-6H-chromeno[4,3-b]quinolines
Authors: Kishore Dakoju Ravi , Mounika Kurella , Satyanarayana Gedu , Goel Komal , Naveen Jakkula 
Published: December 2022

AbstractA convenient, facile, and eco-friendly approach to synthesizing 7-phenyl-6H-chromeno[4,3-b]quinolines under microwave irradiation is presented. The current strategy enabled the synthesis of chromenoquinoline frameworks at 80 °C under shorter reaction times via intermolecular Schiff base formation followed by an intramolecular inverse demand hetero-Diels–Alder [4+2]-cycloaddition reaction by using a catalytic amount of copper triflate as the sole catalyst. Consequently, one C–N and two C–C bonds are constructed in a single pot, and a wide spread of 7-phenyl-6H-chromeno[4,3-b]quinolines have been synthesized with good functional group tolerance.
Simplified Synthesis of an Air-Stable Copper-Complexed Josiphos Ligand via Ugi’s Amine: Complete Preparation and Analysis from Ferrocene
Authors: Johnson Jeffrey S. , Murphy Emma C. 
Published: December 2022

AbstractLigands containing ferrocene backbones often feature both planar chirality and asymmetric centers, making them attractive options for asymmetric catalysis. Ugi’s amine is a ubiquitous ferrocene-based chiral building block that can be functionalized to form a variety of tunable Josiphos ligands; however, few sources lay out the route from start to finish. Starting from ferrocene, we compile a synthetic route to an air- and moisture-stable copper(I)-Josiphos complex via enantiopure Ugi’s amine, providing a potential one-stop shop for the synthesis of a wide range of Josiphos ligands.
Endoscopic Ultrasound Biopsy Needle
Authors: Bush Nikhil , Rana Surinder Singh 
Published: December 2022

AbstractIn the past few years, endoscopic ultrasound (EUS)-guided fine-needle biopsy (EUS-FNB) has superseded EUS-fine-needle aspiration (EUS-FNA) for EUS-guided tissue acquisition. EUS-FNA does not retain the stroma as well as the surrounding tissue architecture and therefore had limitations in achieving a definitive diagnosis. Development of EUS-FNB needles had improved the diagnostic ability of EUS by providing core tissue sample that not only preserves surrounding tissue architecture but also provides adequate material for molecular typing and gene profiling of sampled lesions. At present, there are three commercially available third-generation EUS-FNB needles with unique needle tip designs. In this review, we aim to elucidate the technical aspects of the available EUS-FNB needles.