bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRATAMENTO NA MENOPAUSA: MEDICINA ORTOMOLECULAR DIFERENCIADA PARA UMA VIDA SAUDÁVEL
Authors: De Abreu Agrela Rodrigues Fabiano 
Published: May 2022

A menopausa é um período vida da mulher que ocorre entre os 45 e 55 anos de idade e corresponde ao período que se inicia após um ano da última menstruação. Ela representa o fim do ciclo menstrual e da produção de hormônios. Esse momento atribulado de transição produz diversas mudanças físicas e neuropsicológicas com a manifestação de vários sintomas que prejudicam o bemestar da mulher durante essa fase. Por essa razão, muitas mulheres buscam diferentes formas de tratamentos convencionais e alternativos para aliviar os sintomas. Dentre os tratamentos alternativos, a medicina ortomolecular apresenta uma opção para o alívio dos sintomas de maneira natural e individualizada. O objetivo desse artigo é apresentar os benefícios da medicina ortomolecular para tratamento dos sintomas da menopausa.
Variability Selected Active Galactic Nuclei from ASAS-SN Survey: Constraining the Low Luminosity AGN Population
Authors: Yuk Heechan , Dai Xinyu , Jayasinghe T. , Fu Hai , Mishra Hora D. , Kochanek Christopher S. , Shappee Benjamin J. , Stanek K. Z. 
Published: May 2022

Abstract
Low luminosity active galactic nuclei (LLAGN) probe accretion physics in the low Eddington regime can provide additional clues about galaxy evolution. AGN variability is ubiquitous and thus provides a reliable tool for finding AGN. We analyze the All-Sky Automated Survey for SuperNovae light curves of 1218 galaxies with g < 14 mag and Sloan Digital Sky Survey spectra in search of AGN. We find 37 objects that are both variable and have AGN-like structure functions, which is about 3% of the sample. The majority of the variability selected AGN are LLAGN with Eddington ratios ranging from 10−4 to 10−2. We thus estimate the fraction of LLAGN in the population of galaxies as 2% down to a median Eddington ratio of 2 × 10−3. Combining the BPT line ratio AGN diagnostics and the broad-line AGN, up to ∼60% of the AGN candidates are confirmed spectroscopically. The BPT diagnostics also classified 10%–30% of the candidates as star-forming galaxies rather than AGN.
Thermal Equilibrium Solutions of Black Hole Accretion Flows: Outflows versus Advection
Authors: Wu Wen-Biao , Gu Wei-Min , Sun Mouyuan 
Published: May 2022

Abstract
Observations and numerical simulations have shown that outflows generally exist in the accretion process. We revisit the thermal equilibrium solutions of black hole accretion flows by including the role of outflows. Our study focuses on the comparison of the cooling rate of outflows with that of advection. Our results show that, except for the inner region, outflows can dominate over advection in a wide range of flows, which is in good agreement with previous numerical simulations. We argue that an advection-dominated inner region together with an outflow-dominated outer region should be a general radial distribution for both super-Eddington accretion flows and optically thin flows with low accretion rates.
Spectroscopic Signature of a Re-established Accretion Disk in Symbiotic-like Recurrent Nova RS Ophiuchi
Authors: Azzollini Alessandra , Shore Steven N , Paul Kuin N. 
Published: May 2022

Abstract
A novel method is presented which can pin down the time the accretion disk re-established itself in the RS Oph system after it experienced a nova disruption. The method is based on the re-ionization of the ejecta by photoionization from the radiation released in the boundary layer from accretion.
The Behavior of HgMn Stars in the Far UV-3: 53 Tau and HD 35548
Authors: Monier Richard 
Published: May 2022

Abstract
The analysis of high resolution SWP spectra of the HgMn stars HD 27295 (53 Tau) and HD 33548 obtained through the large aperture recorded by the International Ultraviolet Explorer reveals that the far ultraviolet flux of these two stars remained constant over the various observations with IUE. The TESS lightcurves of 53 Tau show a periodic sine structure with a period estimated to be around 4.43 days whereas that of HD 35548 do not show evidence for periodic variability. The absence of far and mid-UV variability of these two stars precludes the presence of large chemical gradients over their surfaces at the time of the IUE observations.
Quality Assessment of Stereophotoclinometry as a Shape Modeling Method Using a Synthetic Asteroid
Authors: Weirich John , Palmer Eric E. , Daly Michael G. , Barnouin Olivier S. , Getzandanner Kenneth , Kidd John N. , Adam Coralie D. , Gaskell Robert , Lauretta Dante S. 
Published: May 2022

Abstract
The stereophotoclinometry (SPC) software suite has been used to generate global digital terrain models (DTMs) of many asteroids and moons, and was the primary tool used by the Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) mission to model the shape of asteroid Bennu. We describe the dedicated preflight testing of SPC for the OSIRIS-REx mission using a synthetic “truth” asteroid model. SPC has metrics that determine the internal consistency of a DTM, but it was not known how these metrics are related to the absolute accuracy of a DTM, which was important for the operational needs of the mission. The absolute accuracy of an SPC-generated DTM cannot be determined without knowing the truth topography. Consequently, we developed a realistic, but synthetic, computer-generated representation of asteroid Bennu, photographed this synthetic truth model in an imaging campaign similar to that planned for the OSIRIS-REx mission, and then generated a global SPC DTM from these images. We compared the SPC DTM, which was represented by a radius every 70 cm across the asteroid surface, to the synthetic truth model to assess the absolute accuracy. We found that the internal consistency can be used to determine the 3D root-mean-square accuracy of the model to within a factor of two of the absolute accuracy.
Leptospiral infection: a serosurvey in urban and rural communities in Olavarría county, Argentina
Authors: Rivero Mariana Alejandra , Scialfa Exequiel Alejandro , Appendino Héctor Mario , Barbero Melina , Barragán Paola , Martin Félix Carlos , Morón Betsabé , Silva Julia Analia , Tisnés Adela , Estein Silvia Marcela , Signorini Marcelo Lisandro , González Ayala Silvia Elena , Bolpe Jorge 
Published: May 2022

Introduction: Leptospirosis is a neglected zoonotic disease, affecting mainly poor and vulnerable populations.
Methodology: A cross sectional-study was carried out in 557 subjects from Olavarría county (Argentina) to estimate the seroprevalence of leptospirosis and the factors associated with seropositivity. A survey was carried out to obtain clinical and epidemiological data. Serum was tested for anti-leptospiral antibodies by Microscopic Agglutination Test (MAT). Chi-square or Fisher Exact tests were used to assess association between the MAT results and the exploratory variables. For the variables statistically associated, odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated. Individuals from Olavarría city were georeferenced to describe the spatial distribution and to detect clusters of seropositivity for leptospiral antibodies.
Results: The overall prevalence of leptospirosis infection was 7.00%, higher in rural (19.66%) than in urban populations (3.64%) (p < 0.001). Sejroe was the most predominant serogroup in rural communities while Icterohaemorrhagiae was the most prevalent in urban populations. The factors associated with Leptospira infection were the presence of rodents inside households (OR = 3.9) in rural populations, while contact with cats (OR = 4.97) and male gender (OR = 7.75) represented higher risk of infection for the urban ones. Cases with positive serology have been found near Tapalqué stream or in the peripheral areas of Olavarría city.
Conclusions: The results from data obtained during the study period were similar to other reports and demonstrate the importance of continuous epidemiological surveillance system and specific community educational campaigns to prevent the leptospirosis infection in Olavarría county and other communities with similar characteristics especially in rural areas.
Predictors of tuberculosis knowledge among mothers of under-fives, seen at Bingham University Teaching Hospital, Jos Nigeria
Authors: Asuke Sunday , Isah Haroun Omeiza , Jimoh Adenike Oluwayemisi , Achema Timothy 
Published: May 2022

Introduction: Globally, tuberculosis still remains a disease of public health concern and accounts for high morbidity and mortality particularly in developing countries, where it is fuelled by a number of factors.
Methodology: Through a cross-sectional descriptive study, this study aims to determine the predictors of knowledge about TB among 261 mothers of children under 5 years of age attending Child Welfare Clinic, Bingham University Teaching Hospital, Jos, Plateau State, Nigeria.
Results: The mean age of the mothers was 31.54 ± 5.28 years, and 249 (98.4%) aware of TB. About two-third having sufficient knowledge and positive attitude regarding TB. Significant statistical association was found between knowledge and attainment of post-secondary education (OR 4.0; 95% CI 12.09, 7.63; p ˂ 0.001), monthly income ≤ 25,000 naira (OR 2.18; 95% CI 1.02, 4.65; p = 0.042), monthly income > 51,000 naira (OR 3.24; 95% CI 1.43, 7.31; p = 0.005), women engaged in business (OR 0.43; 95% CI 0.22, 0.83; p = 0.012) and possessing positive attitude (OR 3.87; 95% CI 2.16, 6.93; p ˂ 0.001) in the univariate analysis. However, in the multivariate logistic regression, it was only attitude that was found to be a predictor of TB knowledge of mothers.
Conclusions: TB knowledge among the mothers was high, only attitude regarding thoughts and beliefs about TB was found as an independent predictor of TB knowledge. With the positive influence of attitude on knowledge among the mothers, it is recommended that this be strengthened for sustenance to prevent further infection.
Use of qRT-PCR for SARS-CoV-2 sgRNA leader for the therapeutic plan: a preliminary report on 10 patients
Authors: Petcharat Sininat , Virojanapirom Phatthamon , Putcharoen Opass , Wacharapluesadee Supaporn , Hemachudha Thiravat 
Published: May 2022

Introduction: Duration of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) shedding is important for infection control. The presence of SARS-CoV-2 subgenomic RNA (sgRNA) leader indicates that the virus is replicative. This study examined the shedding duration of SARS-CoV-2 sgRNA leader and genomic RNA (gRNA) in diverse respiratory specimens.
Methodology: One hundred and eleven respiratory specimens collected sequentially from 10 COVID-19 patients with real-time RT-PCR SARS-CoV-2 orf1ab gene confirmed positive admitted to King Chulalongkorn Memorial Hospital were examined for SARS-CoV-2 E sgRNA leader and E gRNA by using Real-time reverse transcription PCR (qRT-PCR). These specimens included nasopharyngeal swab and throat swabs, nasal swab and throat swabs, sputum, and endotracheal aspirate, and were collected from the first day of admission until the time of orf1ab real-time RT-PCR negative of at least 2-4 consecutive days.
Results: E sgRNA leader could only be detectable in specimens with ≥ 1E+05 virus E gene copies per ml within the first 15 days after hospitalization. SARS-CoV-2 sgRNA leader was undetectable from one to 15 days earlier than that of gRNA in all patients. Re-shedding of sgRNA was evident in 2 cases, both on a single occasion after being undetectable for 3-10 days.
Conclusions: Assessment of the presence of sgRNA leader may be useful for therapeutic planning.
Hepatitis C virus genotypes and viremia in a tertiary hospital in Istanbul, Turkey
Authors: Alacam Sema , Bakir Ayfer , Karatas Aysel 
Published: May 2022

Introduction: The World Health Organization estimates that 71 million people with chronic HCV infection lived worldwide in 2015. HCV is a globally prevalent pathogen, that genotype1 is the most common. In this study, the prevalence of anti-HCV, distributions of HCV genotype, and viremia rates in patients with chronic hepatitis C were evaluated.
Methodology: In this retrospective single-center study, anti-HCV results of 197,081 patients were evaluated between 2017 and 2020. Quantitative HCV-RNA PCR tests were performed on the Rotor-Gene Q real-time PCR instrument. HCV genotypes determination of 546 samples was carried out with the Gen-C 2.0 Reverse Hybridization strip and HCV Genotype Plus Real-TM kit.
Results: The prevalence of anti-HCV was 0.95% and viremic HCV infection was 0.3% (610/197,081). HCV viremia rate was 33.17%. HCV viremia rate was highest in 2017 (52.36%) and the lowest in 2020 (18.3%) (p < 0.001). Genotype1 (72%) was the most common genotype, followed by genotype3 (14.1%), and genotype4 (8.8%). The most common subtypes were determined as genotype1b (56.2%) and genotype1a (13.2%). The viral load was higher in patients infected with genotype5.
Conclusions: In this study, the rate of viremic HCV infection was found to be 0.3%. This rate was lower than the worldwide rate of HCV viremia. The distribution of HCV genotypes was like the global data. The identification of circulating genotypes and subtypes is essential for epidemiological purposes and remains important in the choice of treatment in patients with chronic HCV.
COVID-19 public health measures reduce the incidence of respiratory infectious diseases
Authors: Wan Zhenzhou , Wang Yulin , Liang Jiao , Cao Yueqin , Lu Renfei , Zhang Chiyu 
Published: May 2022

Background: Children and the elderly are two special subpopulations for coronavirus disease 2019 (COVID-19) and respiratory tract infections (RTIs). The study aimed to evaluate the effect of COVID-19 public health measures on the burden of RTIs in China by performing a two-center investigation.
Methods: The electronic medical records of all inpatients in departments of pediatrics and respiratory medicine of Taizhou Fourth People’s Hospital (Taizhou, China) and Shaanxi Provincial People’s Hospital (Xi’an, China) during January 1, 2019 to June 30, 2021 were analyzed. A total of 18,084 child inpatients and 14,802 adult inpatients were included.
Results: The vast majority (88.3%-90.6%) of the adult inpatients were the elderly, aged over 50 years. The numbers of child and adult (elderly) inpatients, and the proportions of RTI-associated diseases substantially decreased during COVID-19 pandemic (2020-2021) compared to that before the pandemic (2019) in Taizhou and Xi’an. A significantly higher proportion of LRTI-associated diseases was observed in elderly female inpatients (53.4-55.6%) than elderly male inpatients (34.3-41.5%) (p < 0.001) in spite of more male inpatients than female inpatients (1.94-1.95:1).
Conclusions: COVID-19-related interventions provide an additional beneficial effect on reduction of RTI-associated diseases in both children and the elderly.
Biomechanical Evaluation of Topographically and Tomographically Normal Fellow Eyes of Patients With Keratoconus
Authors: Asroui Lara , Dagher Samir A. , Elsheikh Ahmed , Lopes Bernardo T. , Roberts Cynthia J. , Assouad Marc , Awwad Shady T. 
Published: May 2022

PURPOSE:
To determine the effectiveness of parameters and indices based on biomechanical measures at discriminating fellow eyes with topographically and tomographically normal corneas in patients with keratoconus from normal control corneas.

METHODS:
The study included 47 keratoconus suspect eyes, defined as the topographically and tomographically normal fellow eyes of patients with frank keratoconus in the other eye. Eyes were imaged using the Pentacam HR and Corvis ST (both Oculus Optikgeräte GmbH). Fellow eyes were then categorized as topographically/tomographically normal fellow eyes (TNF) and topographically/tomographically borderline fellow eyes (TBF). The ability of each of the Corvis Biomechanical Index (CBI), Tomographic and Biomechanical Index (TBI), stiffness parameter at applanation 1 (SP-A1), and stress-strain index (SSI) at discriminating between normal controls and keratoconus suspects was assessed.

RESULTS:

The TBI had the best discriminative ability with the greatest area under the receiver operating characteristic (AUROC) curve value of 0.946 for normal controls versus TBF eyes, and 0.824 for normal controls versus TNF eyes. Compared to the TBI AUROC curves, SP-A1 and CBI had AUROC curve values of 0.833 (
P
= .09) and 0.822 (
P
= .01) for normal controls versus TBF eyes, respectively, and AUROC curve values of 0.822 (
P
= .96) and 0.550 (
P
= .0002) for normal controls versus TNF eyes, respectively. The TBI had the best positive predictive value for TNF and TBF eyes, followed by CBI and SP-A1.

CONCLUSIONS:
The TBI and the purely biomechanical parameter SP-A1 were of moderate utility in distinguishing between normal and keratoconus suspect eyes. In the absence of topographic/tomographic evidence of keratectasia, an independently abnormal biomechanical parameter may suggest an increased risk of ectasia.

[
J Refract Surg
. 2022;38(5):318–325.]
Small Incision Lenticule Extraction (SMILE) for the Correction of High Myopia With Astigmatism
Authors: Reinstein Dan Z. , Archer Timothy J. , Vida Ryan S. , Carp Glenn I. , Reinstein Julia F. R. , McChesney Theo , Potter Joseph G. 
Published: May 2022

PURPOSE:
To report the outcomes of small incision lenticule extraction (SMILE) for high myopia between −9.00 and −14.00 diopters (D).

METHODS:
This was a prospective study of SMILE for high myopia using the VisuMax femtosecond laser (Carl Zeiss Meditec). Inclusion criteria were attempted spherical equivalent refraction (SEQ) between −9.00 and −14.00 D, cylinder up to 7.00 D, corrected distance visual acuity (CDVA) of 20/40 or better, age 21 years or older, and suitable for SMILE. The sub-lenticule thickness was 220 µm or greater, and the total uncut stromal thickness was 300 µm or greater. Patients were to be followed up for 1 year. Standard outcomes analysis was performed using 12-month data where available or 3-month data otherwise.

RESULTS:
Of 187 eyes treated, data were available at 12 months for 181 eyes (96.8%) and 3 months for 4 eyes (2.1%), and 2 eyes (1.1%) were lost to follow-up. Mean attempted SEQ was −10.55 ± 1.00 D (range: −9.00 to −12.99 D). Mean cylinder was −1.19 ± 0.83 D (range: 0.00 to −4.00 D). Preoperative CDVA was 20/20 or better in 73% of eyes. Postoperative uncorrected distance visual acuity was 20/20 or better in 57% and 20/25 or better in 82% of eyes. Mean SEQ relative to target was −0.22 ± 0.48 D (range: −1.63 to +1.38 D), 66% ± 0.50 D and 93% ±1.00 D. Mean SEQ 12-month change was −0.08 ± 0.34 D (range: −1.75 to +0.88 D). There was loss of one line of CDVA in 4% of eyes, and no eyes lost two or more lines. Contrast sensitivity was unchanged. Patient satisfaction was 8 or more out of 10 in 94% and 6 or more in 99% of patients.

CONCLUSIONS:
Outcomes of SMILE for myopia greater than −9.00 D at 3 to 12 months showed excellent efficacy, safety, stability, and predictability, with high patient satisfaction.

[
J Refract Surg
. 2022;38(5):262–271.]
SG-LOM as Metadata Description for Serious Games to Benefit from LMS Monitoring Features
Authors: El Borji Yassine , El Haji Essaid 
Published: May 2022

Compared to the conventional approach of e-learning, serious games are playing an increasingly important role in the educational sphere and reached a certain maturity to become a possible alternative to traditional methods of learning that is often seen as restrictive and boring sometimes by learners. This is due to the fact that young people today are familiar with new technologies and virtual worlds outside schools as part of their leisure. A habit that enable these young people to be immediately in the heart of the matter since they already have a video game culture (gameplay) that allows them to focus on the main message. However, the integration of serious games in the learning process still limited since they don’t provide efficient features for monitoring and assessing learner (player) interactions and decisions without breaking the nonlinearity of the game in order to show them the consequences of their decisions, a limit that has been proven in a previous comparative study [1].
In this paper we address the aspects of serious games (Robocode as example) integration and deployment into LMS (Dokeos as example) based on the automatic packaging and exportation of serious games as reusable learning objects (LO) that can be easily distributed through any LMS. This integration uses the ADL SCORM data model that defines how content may be packaged as a Package Interchange File (PIF), and the IEEE LOM Application Profile “SG-LOM” [2] as metadata description to describe every level of SCORM since the standard LOM doesn’t meets the particular needs of serious games.
Fuzzy Logic-Based Evaluation Model of Handwritten Font Sizes Readability on Extra Small Devices
Authors: Bratić Diana , Stanić Loknar Nikolina , Koren Ivančević Tajana 
Published: May 2022

Handwritten fonts are appealing to designers, but their application in web design can cause a readability problems. Different handwritten letter cuts in different font sizes are not equally readable on all screen types. The problem often occurs on extra small devices such as mobile phones. Therefore, it is necessary to choose the combination of the font type and appropriate font size that will ensure responsiveness and be readable on different devices, especially the small ones. For this purpose, a study of readability of monoline handwritten font in seven letter cuts (thin, ultra-light, light, regular, semi-bold, bold, and ultra-bold) in several font sizes was conducted. Variable font was used because it contains all style versions of one typeface family, as opposed to standard font families that use different files for each style version. Also, variable font is suitable for use on web because one file with all the necessary typeface styles is significantly smaller in size than classic families with multiple files which shortens the font loading time. Furthermore, model of readability evaluation using the fuzzy logic based postprocessing method for segmentation values related to evaluation criteria is proposed. Prototype of a variable handwritten fonts are tested in responsive web environment, using CSS technology. The results show that handwritten font size readability evaluation has measurable output because the score combine various numeral factors affecting the readability of particular font size in several letter cuts. Using of proposed model in short time can show readability level of some font type in some font size on a new responsive web suitable for different screen sizes, including extra small devices.