bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of religiousness on life satisfaction and anxiety level of the patients with depression disorders treated at the neuro-psychiatric center in riem, munich
Authors: Herbrüggen E.D. Cindik , Akdag B. 
Published: February 2022

IntroductionReligious people suffer less from depression disorder than less or non-religious people. According to a longitudinal study investigating religiousness and negative life events, religious participants demonstrated fewer depressive symptoms than non-religious. Furthermore, depressed patients with higher religiosity scores show lower values of depression symptoms.ObjectivesThe purpose of the study was to investigate the relationship between religiosity and patients with depression symptoms in the Neuro-Psychiatric Center in Riem (NPZR). The correlation between religiousness and life satisfaction as well as anxiety level was analyzed. Additionally, possible gender differences are also assesed.MethodsThe patients of the NPZR were selected as sample of the study (N =106, F=61, M=45). The participants were provided with three surveys including the life satisfaction questionnaire, state trait anxiety inventory and the Centrality Scale. A Pearson Correlation was conducted to investigate the association between life satisfaction, level of anxiety and religiousness. T-Test was carried out to find out the differences between female and male patients.ResultsThere was a positive relationship between religiousness and life satisfaction of the depressed patients (r = .608, p= .001). There was also a significant relationship between religiosity and anxiety level (r = - .548, p < .001). However there was no significant difference between male and female patients with regard to their religiousness (t= .149, p= .882).ConclusionsThe findings indicate that while there is a significant relationship between life satisfaction, level of anxiety and religiousness of the patients, the gender of the patients has no impact on the religiosity of participants.
Correlation of dsm-5-based and hads self-reported depression phenotypes: Preliminary results of on-line survey in russian population cohort
Authors: Rukavishnikov G. , Rakitko A. , Kasyanov E. , Ilinsky V. , Kibitov A. , Mazo G. , Neznanov N. 
Published: February 2022

IntroductionTo reduce the heterogeneity of depressive GWAS samples it seems relevant to evaluate and compare current instruments for depression phenotyping.ObjectivesThe aim is to evaluate the agreement of DSM criteria and HADS scores in depression phenotyping for population studies.MethodsThe self-report data was obtained from 5116 clients (females 50,63%; mean age 36,92±9,82 years, Ме=42; Q1=35, Q3=76) of genetic testing company Genotek Ltd.. The respondents completed an on-line questionnaire with items on social status and biometrics. Depression phenotyping was based on DSM-5 criteria (life-time and current for major and bipolar depression) and HADS (current).ResultsMean HADS scores were: HADS-A – 6,43±2,9, Ме=8; Q1=6, Q3=18; HADS-D – 4,5±2,83, Ме=6; Q1=4, Q3=17. Abnormal anxiety and depression (≥11 for each subscale) were present in 9% (N–456) and 3,4% (N–174) of respondents, respectively; borderline (8-10) – in 23% (N–1172) and 11,9% (N–592), respectively. The life-time report of major depression according to DSM-5 criteria was 17,6% (N–261) and of bipolar disorder – 8,3% (N–139). Moderate correlations were present for borderline HADS anxiety scores and DSM major depression (0.19, p<.01). Similar correlations of HADS anxiety scores were registered for DSM bipolar depression (0.20, p<.01). Moreover, HADS depression scores did not correlate with any DSM depressive phenotype.ConclusionsOur study shows significant correlations only for DSM depression criteria and HADS anxiety, but not depression scores. It could indicate the different significance of individual scale items in depression phenotyping and the need for their separate further evaluation.Conflict of interestThe research is supported by the Russian Scientific Fund grant #20-15-00132.
Improvements in mood symptoms, cognitive symptoms and functioning in outpatients with mdd in greece treated with vortioxetine: A patient-rated evaluation
Authors: Galanopoulos A. , Tsiolka E. , Ntounas P. , Mpelimpasakis D. , Karakoutas D. , Sidiropoulos N. , Mpougiouklis I. , Kyziridis K. , Papalexi E. 
Published: February 2022

IntroductionFunctional recovery is the contemporary treatment goal in Major Depressive Disorder (MDD). Although consistency among physician and patient expectations may influence the therapeutic result (Demyttenaere K et al, 2011), patients’ perceptions are not always fully captured. Vortioxetine,a multimodal antidepressant, has shown encouraging data in achieving functional recovery, improving both mood and cognitive symptoms (Mahableshwarkar AR et al, 2015).ObjectivesThe aim of the study was to assess the effectiveness of vortioxetine on mood symptoms, cognitive symptoms and functionality, assessed by patient-rated tools, in MDD outpatients in Greece.MethodsIn this non-interventional study, vortioxetine was administered as flexible dosing (5-20 mg/d). Mood symptoms, cognitive symptoms and functioning were assessed by the patient-rated scales PHQ-9, PDQ-D and SDS respectively, at baseline, 1 and 3 months. Repeated measures analysis of variance and t-test were used for the statistical analyses.Results336 patients participated in the study. PHQ-9 score ±SD decreased from 16.1±5.3, to 10.0±5.7 and 4.6±4.5, PDQ-D score ±SD decreased from 37.3±16.6 to 23.1±14.8 and 12.0±10.6, SDS Score ±SD decreased from 18.7±5.3 to 12.9±5.9 and to 7.8±6.5, at baseline, 1 and 3 months, respectively. The 3 SDS subscales: work/school life improved from 5.8±2.4 to 4.2±2.2 and 2.6±2.2, social life improved from 6.6±2.0 to 4.5±2.2 and 2.7±2.3 and family life improved from 6.3±2.0 to 4.3±2.1 and 2.6±2.3 -baseline, 1 and 3 months, respectively (p<0.001 for all paired comparisons).ConclusionsMDD patients in Greece treated with vortioxetine significantly improved on mood symptoms, cognitive symptoms and functioning, enriching the already published efficacy data which is mostly based on clinician-rated scales.Conflict of interestA. Galanopoulos and E. Papalexi are full-time employees in Lundbeck Hellas.
Efficacy and safety of mij821 in patients with treatment-resistant depression: Results from a randomized, placebo-controlled, proof-of-concept study
Authors: Ghaemi N. , Sverdlov A. , Shelton R. , Litman R. 
Published: February 2022

IntroductionMIJ821 is a novel N-methyl-D-aspartate (NMDA) receptor antagonist, with a potentially low rate of the psychotomimetic side effects that limit the therapeutic utility of ketamine in treatment-refractory depression (TRD).ObjectivesTo assess efficacy and safety of MIJ821.MethodsAdults with TRD (>2 prior treatment failures; Montgomery-Asberg Depression Rating Scale [MADRS], >24) were eligible and were randomized (n=70) to low versus high doses of MIJ821, with two dosing regimens of weekly or biweekly, versus ketamine versus placebo. The primary outcome was change in MADRS total score at 24 hours and final follow up was at 6 weeks.ResultsAt 24 hours, adjusted mean differences (ΔAM) versus placebo were –8.25 (p=0.001), –5.71 (p=0.019) and –5.67 (p=0.046) and at 48 h were –7.06 (p=0.013), –7.37 (p=0.013), –11.02 (p=0.019) in the pooled MIJ821 low dose, high dose, and ketamine groups, respectively. At 6 weeks, ΔAM (80% CI) versus placebo on MADRS were –6.46 (–11.8, –1.15); p=0.059 for low dose MIJ821, –5.42 (–10.8, –0.02); p=0.099) for high dose MIJ821, and –5.24 (–10.4, –0.06); p=0.097 for ketamine. Further details on dosing, efficacy, and safety outcomes will be provided.ConclusionsIn this proof-of-concept study, MIJ821 was effective and tolerable in TRD. This study was funded by Novartis. Clinical trial.gov: NCT03756129Conflict of interestEmployee of Novartis.
Pessimistic attributional style for positive life events as a predictor of low mental health in russian sample
Authors: Gordeeva T. , Sychev O. 
Published: February 2022

IntroductionAttributional style (AS) indicates cognitive dispositions for explaining positive and negative events. People with pessimistic АS explain failure with stable and global causes. Previous studies and meta-analyses (Hu et al., 2015; Peterson et al., 1985; Zhang et al., 2014) showed that pessimistic AS for failures is a reliable predictor of depression and ill-being, but the possible mediators of such relations are understudied.ObjectivesOur main objective was to analyse relations of pessimistic AS for success and failure with mental health. We hypothesized that pessimistic AS would be a predictor of low mental health mediated by self-esteem, dispositional optimism, and gratitude.MethodsA cross-sectional study was conducted on a sample of 261 adults (MA=32.09, SD=12.53, 13% male) using a 24-item attributional style questionnaire (SFASQ, Gordeeva et al., 2009), mental well-being scale (Tennant et al., 2007), self-esteem scale (Rosenberg, 1965), gratitude questionnaire (McCullough et al., 2002), and LOT (Scheier, Carver, 1985).ResultsA path model of effects of pessimistic AS in positive and negative situations on mental ill-being was developed. The model with three mediators fits the data very well: CFI=0.990; RMSEA=0.048. The pessimistic attributional style for positive events was a significant predictor of mental ill-being mediated by self-esteem, dispositional optimism, and gratitude while the indirect effect of pessimistic AS for failures on mental ill-being (controlling for age) was not significant.ConclusionsOnly the pessimistic AS for successes but not for failures was a significant predictor of mental ill-being which underline the importance of stable and global attributions of positive life events for mental health.
Family history of mood disorders and concomitant psychopathology in patients with depression
Authors: Kasyanov E. , Nikolishin A. , Rukavishnikov G. , Kibitov A. , Mazo G. 
Published: February 2022

IntroductionA family history (FH) of mood disorders is an important clinical feature that affects the risk of depression and its clinical manifestations during the course of the disease.ObjectivesTo assess the impact of FH in patients with depression on the presence of concomitant psychiatric disorders.MethodsThis cross-sectional study included 172 patients with depression (64.5% women; age - 40,87±15,86 years). The M.I.N.I. was conducted to verify the diagnosis of psychiatric disorders. FH is based on indirect reports of patients.ResultsThe most prevalent concomitant psychiatric diagnoses in patients with depression were generalized anxiety disorder (GAD; 26,2%), panic disorder (24,4%) and social anxiety disorder (13,4%). FH was recorded in 52 (30.2%) patients with depression. Patients with depression and FH more often had concomitant GAD (with FH - 20 (38,5%), without FH - 25 (20,8%); p=0.016). Women with depression and FH showed a higher rate of early onset (before age 18) of depression (with FH - 10 (32,3%), without FH - 10 (12,5%); p=0.015). Men with depression and FH more often had concomitant GAD (with FH - 10 (47,6%), without FH - 8 (20%); p=0.025). Logistic regression revealed that FH was associated with GAD in patients with depression (p=0.019).ConclusionsFH of mood disorders in patients with depression is associated with specific concomitant psychopathology. Further genetic studies are needed to explain this comorbidity.
Delta and theta eeg activity during resting state is altered in patients affected by major depression
Authors: Spironelli C. , Fusina F. , Angrilli A. 
Published: February 2022

IntroductionMajor depression (MD) is associated with cognitive and behavioral alterations in many domains. It is not well clear what cortical structures and functional alterations characterize MD patients during resting state, a condition during which mind wandering process is prevailing.ObjectivesIn MD patients with severe levels of depression we expected, during resting state, an altered asymmetry of cortical activity in the EEG bands that generally mark neurological impairment, i.e. Delta and Theta EEG bands.Methods30 MD patients under pharmacological treatment and 32 matched controls underwent an EEG recording (38 scalp sites) during 5 min resting state with open eyes. Eye movements were corrected by ICA modeling and the 5 min recording was divided in 2 sec epochs from which Delta and Theta spectral powers were extracted.ResultsSpectral analysis of the 5 min resting state revealed a significant difference between the two groups at the level of left temporal lobe. MD patients showed larger Delta and Theta spectral power in the left superior temporal gyrus at the level of Brodmann’s Areas 22 and 42.ConclusionsResults evidenced a cortical inhibition (greater EEG Delta and Theta activity) in left temporal linguistic areas in severe depression, a result pointing to a different mind wandering process and thought architecture in MD patients during resting state.
Insideout project: Using big data and machine learning for prevention in psychiatry
Authors: Nastro F. Fiori , Croce D. , Schmidt S. , Basili R. , Schultze-Lutter F. 
Published: February 2022

IntroductionSocial Media might represent an amazing and valuable source of information on mental health and well-being. Several researches revealed that adolescents aged 13 to 17 years old go “online” daily or stay online “almost constantly”.ObjectivesThe aim of this project is to identify distress in pre-clinical stages using Social media screening methods. The system can be modelled to centre on different several health-related topics.MethodsWe created a digital system able to analyse scripts written by adolescents on Twitter. InsideOut works using machine learning techniques and computational linguistic items to catch significant and sense of written messages and it improves its performances with iterations. The system is able to automatically identify semantic information relevant to different topics: in this case “distress in teenagers”.ResultsThe task of our system is considered correct when it is able to identify triples of Life Event, Sentiment and Experience of a tweet in agreement with the Gold Standard established among the annotators. The system has around 70% of accuracy in identifying triples. The analysis has been carried out both in Italian and English collecting over 4 million Italian tweets and 30 million English tweets. Comparative analysis with self-report questionnaires show that tweet analysis is able to suggest similar statistics.ConclusionsThis study analyzed contents of messages posted on Social Media Twitter meta-dating them with psychological and health-related information. Using InsideOut, we can plan clinical intervention in district and regions where high levels of uneasiness are revealed.
The impact of physical distancing on body-image and social media use
Authors: Corazza O. 
Published: February 2022

The current coronavirus pandemic (Covid-19) is posing new critical challenges on mental health due to widespread social alarm as well as long lasting “physical distancing” as a result of public health protection measures or voluntary conduct. In a period of uncertainty, certain rewarding behaviors, such as the use of the Internet, exercise among other coping strategies might have increased considerably. We will share the results of an international cross-sectional investigation on the impact of physical-distancing on such potentially addictive behaviours to mitigate the pandemic effects, while identifying the most risky patterns and vulnerable populations. The studied sample consists of 3161 participants from Italy (41%), Spain (16%), the UK (12%), Lithuania (12%), Portugal (11%), Japan (6%), and Hungary (4%). Results are currently being analysied.DisclosureNo significant relationships.
“Prevalence of orthorexia nervosa in a sample of patients attending sligo/leitrim mental health services with a diagnosis of eating disorder”
Authors: Graffeo I. , Harron M. , O’Mahony E. 
Published: February 2022

IntroductionThe term Orthorexia derives from the Greek “ortho – correct” and “orexis – appetite”; Orthorexia Nervosa is a pathological fixation with healthy eating that, starting with the idea to obtain a maximum health with a proper diet, leads to malnourishment and other medical sequelae, loss of relationships, loss of self-esteem, poor quality of life in general. Orthorexia, despite receiving broad empirical evidence, is not currently included in any psychiatric diagnostic manual.ObjectivesThe main aim of this study is to investigate its presence in a sample of patients already diagnosed with a canonical eating disorder and also to understand eventual overlaps with other clinical disorders in order to optimize treatment and follow up.MethodsThe ORTO-15 questionnaire, developed by an Italian team of researchers in 2005, was used to achieve the above aims: it is a tool comprehensive of 15 questions that assesses eating habits perceived as healthy. Really interesting and fascinating is to comprehend if people with a diagnosis of eating disorder present orthorectic behaviour and how this emerging reality fits in the Irish society with its peculiarities and uniqueness.ResultsThe Point Prevalence obtained is 17.9%. The expected rates of Orthorexia Nervosa in the general population are between 6.9% and 57.6%, with a peak of 81.8% in specific populations, fact that places our examined sample in the lower side of the prevalence previously considered in other studies.ConclusionsIt is significant the absence of correlation found between OCD and ON and that ON is more linked to Bulimia Nervosa rather than Anorexia Nervosa.
A clinical case of typical anorexia nervosa in a prepubescent boy
Authors: Bryukhin A. , Sologub M. , Sineutskaya E. , Matsneva M. , Zakharova A. , Okonishnikova E. , Lineva T. 
Published: February 2022

IntroductionClinical case of 10-year-old patient with anorexia nervosa at the stage of severe cachexia. Features of the disease, diagnosis, treatment and methods of restoration of nutrition. Anorexia nervosa is an eating disorder (ED), severe pathology, manifested by severe complications, high disability and can cause death. ED has traditionally been perceived as a disease affecting women. However, this pathology occurs men, is 10-25% of the total number of patients with ED, or 1-2% in the population.ObjectivesDescribe the difficulties in identifying ED in men that affect diagnosis and treatment, especially if they are underage patients.MethodsPatient I. 10 years, selectivity in food from 4 years, during the week before hospitalization complete rejection of food and water. When entering the clinic height 127, weight 19 kg, BMI 11. In the clinical picture anxiety, low mood, fear of eating and weight gain. The duration of the disease for about one year. Clinical and psychopathological method.ResultsDiagnosis F50.0 anorexia nervosa in the stage of severe cachexia. Treatment: olanzapine and fluvoxamine in the age dosages, parenteral Kabiven infusion, individual and group psychotherapy. Psychoeducation of parents and Maudsley method therapy. As a result of treatment improved mood, decreased anxiety associated with eating and weight gain. At the time of discharge from the clinic height 127, weight 30 kg, BMI 18.ConclusionsThe clinical case indicates the need to increase the attention of pediatricians, psychologists, psychiatrists and other doctors in connection with the growth and rejuvenation of ED in the male population.
The tpe - teresa project: Enhancing long-term management in obesity and binge eating disorder
Authors: Prosperi E. , Guidi G. , Calabria M.F. , Gnessi L. , Iocchi L. 
Published: February 2022

IntroductionTherapeutic Education (TE) is a powerful tool in the multidisciplinary intervention to improve lifestyle and acquire management skills for chronic diseases, including obesity, a clinical condition whose cure is highly threatened by low long-term adherence to therapeutic recommendations. The urgent need to promote persistent lifestyle change and concordance to treatment in PwO is globally recognized. TE programs offer a vast number of long-term management skills, but it yet deals with a consistent drop-out rate, and we believe that Assistive Technologies (AT) can become a powerful tool to boost independence and improve participation.ObjectivesThe goal of our study was to devise and validate an innovative multidisciplinary approach to obesity and binge eating disorder, based on the sinergy between the medical-psychological field and assistive techonolgy.MethodsWe developed “TERESA” (Therapeutic Educational Robot Enhancing Social interActions) (fig. 1), a social humanoid robot, and implemented it to collaborate in a TE programs in order to enhance social interactions, improve knowledge acquisition and adherence to treatment. The specific TE intervention, called Education towards Choice and Awareness, was based on 3rd generation cognitive-behavioral approaches and consisted in eight informative and experimental meetings.ResultsTaking part in the TE-TERESA integrated protocol determined and improvement in psychopathological domains (anxiety, negative mood, quality of life) and a stronger concordance to the therapeutic protocol.ConclusionsOur research paves the way for the clinical use of Assistive technology (AT), highly promoted by the WHO to help people with numerous disabling clinical conditions improve their quality of life and acquire self-management skills.
Crowding analysis for patients with mental disorders during the first pandemic wave of 2019 coronavirus epidemic (CoViD-19) at a lombardy ED
Authors: Savioli G. , Pesenti S. , Ceresa I. , Oddone E. , Bressan M.A. 
Published: February 2022

IntroductionThe 2019 coronavirus epidemic (CoViD-19) in Italy originated in Lombardy, on February 21, 2020. Crowding has been defined as a worldwide problem and causes reduced quality of care. It is due and identified by three orders of factors: those at the access (input); those related to the patient’s process (throughput); and those at the exit from the ED (output).ObjectivesWe evaluated all the population who went to ED for mental disorder. Due to the high level of care needed and the simultaneous exposure to risk factors, an excessive duration of ED process can be counterproductive.MethodsWe evaluated all patients accessing our ED for mental disorder from February 22 to May 1, 2020 and during the same period of the previous year.ResultsWe enrolled 345 patients. The Crowding input factors are lower in the pandemic period: reduced attenders (142 vs 203) and reduced average waiting times (40 min vs 54 min). The Crowding throughput factors have instead worsened: LOS (length of stay) for both visit rooms (383 vs 271 min) and holding area (1735 min vs 797 min). The Crowding output factors also worsened: the percentage of access block is higher during the pandemic (100% vs 20%). The Total Access Block Time is significantly higher in the CoViD period for both the visit rooms (3.239 vs 649 min) and the holding area (590 vs 185 min).ConclusionsThe pandemic period presented a worsened crowding for these patients due to the Access Block.