bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of supervised and unsupervised anomaly detection in Belle II pixel detector data
Authors: Dort Katharina , Bilk Johannes , Käs Stepahnie , Lange Jens Sören , Peter Marvin , Schellhaas Timo , Schwenker Benjamin , Spruck Björn 
Published: July 2022

AbstractMachine learning has become a popular instrument for the search of undiscovered particles and mechanisms at particle collider experiments. It enables the investigation of large datasets and is therefore suitable to operate directly on minimally-processed data coming from the detector instead of reconstructed objects. Here, we study patterns of raw pixel hits recorded by the Belle II pixel detector, that is operational since 2019 and presently features 4 M pixels and trigger rates up to 5 kHz. In particular, we focus on unsupervised techniques that operate without the need for a theoretical model. These model-agnostic approaches allow for an unbiased exploration of data while filtering out anomalous detector signatures that could hint at new physics scenarios. We present the identification of hypothetical magnetic monopoles against Belle II beam background using self-organizing kohonen maps and autoencoders. These two unsupervised algorithms are compared to a Multilayer Perceptron and a superior signal efficiency of the Autoencoder is found at high background-rejection levels. Our results strengthen the case for using unsupervised machine learning techniques to complement traditional search strategies at particle colliders and pave the way to potential online applications of the algorithms in the near future.
Sintering parameters influence on dielectric properties of modified nano-BaTiO3 ceramics
Authors: Stajcic Aleksandar , Stajcic Ivana , Mitic Vojislav V. , Lu Chun-An , Vlahovic Branislav , Vasiljevic-Radovic Dana 
Published: July 2022

BaTiO3 (BTO) is considered the most commonly used ceramic material in multilayer ceramic capacitors due to its desirable dielectric properties. Considering that the miniaturization of electronic devices represents an expanding field of research, modification of BTO has been performed to increase dielectric constant and DC bias characteristic/sensitivity. This research presents the effect of N2 and air atmospheres on morphological and dielectric properties of BTO nanoparticles modified with organometallic salt at sintering temperatures of [Formula: see text]C, [Formula: see text]C, [Formula: see text]C, and [Formula: see text]C. Measured dielectric constants were up to 35,000, with achieved very high values in both atmospheres. Field emission scanning electron microscopy (FESEM) was used for morphological characterization, revealing a porous structure in all the samples. The software image analysis of FESEM images showed a connection between particle and pore size distribution, as well as porosity. Based on the data from the image analysis, the prediction of dielectric properties in relation to morphology indicated that yttrium-based organometallic salt reduced oxygen vacancy generation in N2 atmosphere. DC bias sensitivity measurements showed that samples with higher dielectric constant had more pronounced sensitivity to voltage change, but most of the samples were stable up to 100 V, making our modified BTO a promising candidate for capacitors.
EXPERTISE: An Effective Software-level Redundant Multithreading Scheme against Hardware Faults
Authors: So Hwisoo , Didehban Moslem , Ko Yohan , Shrivastava Aviral , Lee Kyoungwoo 
Published: July 2022

Error resilience is the primary design concern for safety- and mission-critical applications.
Redundant MultiThreading (RMT)
is one of the most promising soft and hard error resilience strategies because it does not require additional hardware modification. While the state-of-the-art software RMT scheme can achieve a high degree of error protection, our detailed investigation revealed that it suffers from performance overhead and insufficient fault coverage. This paper proposes EXPERTISE, a compiler-level RMT scheme that can detect the manifestation of hardware faults in all processor components. EXPERTISE transformation generates a checker-thread for the main execution thread. These redundant threads are executed simultaneously on two physically different cores of a multicore processor and perform almost the same computations. After each memory write operation is committed by the main-thread, the checker-thread loads back the written data from the memory and checks it against its own locally computed values. If they match, the execution continues. Otherwise, the error flag is raised. In order to evaluate the effectiveness of the proposed solution, we performed soft and hard error injection experiments on all the different hardware components of an ARM Cortex53-like μ-architecturally simulated microprocessor. Based on statistical fault injection campaigns, we have found that EXPERTISE provides 188× better fault coverage with 27% faster performance as compared to the state-of-the-art scheme.
Epidemiology and Transmission Dynamics of COVID-19 in an Urban Pediatric US Population
Authors: Sebastian Thresia , Carlson Jesse J. , Gaensbauer James , Podewils Laura Jean 
Published: July 2022

Objective: This analysis summarizes observational epidemiologic data and transmission dynamics of SARS-CoV-2 among people aged <18 years to better characterize the pediatric COVID-19 pandemic. Methods: We conducted a retrospective study of public health surveillance data among children in Denver, Colorado, who were reported to have COVID-19 from March 1, 2020, through September 30, 2021. We used descriptive statistics and bivariate rate ratios (RRs) to describe demographic and clinical characteristics, transmission dynamics, case trends, and ecological associations. Results: A total of 9815 children and adolescents who had COVID-19 were reported during the study period. Adolescents aged 14-17 years had the highest incidence rate (IR) per 1000 people (IR = 107.5; 3021 of 28 108). Hispanic/Latino children had a 1.6 times higher rate of infection than non-Hispanic White children (RR = 1.57; 95% CI, 1.50-1.65; P < .001). Few hospitalizations (n = 138, 1.4%) and deaths (n = 3, 0%) occurred. Most children were symptomatic (4487 of 5499, 81.6%). Within household clusters, a large proportion of pediatric cases (n = 6136) were a secondary case (n = 3959, 64.5%), followed by index case (n = 1170, 19.1%) and co–index case (n = 1007, 16.4%). Non-Hispanic White children had an increased risk of being an index or co–index case (RR = 1.14; 95% CI, 1.06-1.23; P < .001), while Hispanic/Latino children had an increased risk of being a secondary case (RR = 1.07; 95% CI, 1.03-1.11; P < .001). From 2020 to 2021, the association between pediatric case rates and neighborhoods with higher poverty and households with ≥3 people decreased. Conclusions: Older children and those identifying as Hispanic/Latino had a disproportionate incidence of disease. A sizable proportion of children were considered index cases or co–index cases. Pediatric prevention strategies, especially vaccinations, are vital for pandemic control.
The Longitudinal Association Between Childhood Abuse and Positive and Negative Family Interactions in Midlife and Older Adults: The Role of Mindfulness Meditation and Gender
Authors: Fitzgerald Michael , Notice Maxine 
Published: July 2022

Objectives Childhood abuse has been linked to problematic familial relationships in adulthood; however, it remains unclear what factors buffer the association. Mindfulness research has demonstrated promise in improving relationships among adults abused during childhood, but research has focused on couples, with fewer studies examining familial relationships. Methods Using a data sample of 2430 adults from the Midlife Development in the United States, the current study examined mindfulness as a moderator of childhood abuse and familial support and strain in adults. Results Analysis of hierarchical regression revealed that mindfulness was a moderator of childhood abuse and family strain over a 10-year period in women, but not men. However, mindfulness did not moderate childhood abuse and support. Discussion This examination of mindfulness in the context of familial relationships may help women more successfully manage negative familial interactions. Results indicate mindfulness-based interventions may be helpful in improving familial relationships among adults abused by family members in childhood.
Bereavement outcomes in family members of those who died in acute care hospitals before and during the first wave of COVID-19: A cohort study
Authors: Downar James , Parsons Henrique A. , Cohen Leila , Besserer Ella , Adeli Samantha , Gratton Valérie , Murphy Rebekah , Warmels Grace , Bruni Adrianna , Bhimji Khadija , Dyason Claire , Enright Paula , Desjardins Isabelle , Wooller Krista , Kabir Monisha , Noel Chelsea , Heidinger Brandon , Anderson Koby , Arsenault-Mehta Kyle , Lapenskie Julie , Webber Colleen , Bedard Daniel , Iyengar Akshai , Bush Shirley H , Isenberg Sarina R , Tanuseputro Peter , Vanderspank-Wright Brandi , Lawlor Peter 
Published: July 2022

Background: The COVID-19 pandemic has caused millions of deaths worldwide, leading to symptoms of grief among the bereaved. Neither the burden of severe grief nor its predictors are fully known within the context of the pandemic. Aim: To determine the prevalence and predictors of severe grief in family members who were bereaved early in the COVID-19 pandemic. Design: Prospective, matched cohort study. Setting/Participants: Family members of people who died in an acute hospital in Ottawa, Canada between November 1, 2019 and August 31, 2020. We matched relatives of patients who died of COVID (COVID +ve) with those who died of non-COVID illness either during wave 1 of the pandemic (COVID −ve) or immediately prior to its onset (pre-COVID). We abstracted decedents’ medical records, contacted family members >6 months post loss, and assessed grief symptoms using the Inventory of Complicated Grief-revised. Results: We abstracted data for 425 decedents (85 COVID +ve, 170 COVID −ve, and 170 pre-COVID), and 110 of 165 contacted family members (67%) consented to participate. Pre-COVID family members were physically present more in the last 48 h of life; the COVID +ve cohort were more present virtually. Overall, 35 family members (28.9%) had severe grief symptoms, and the prevalence was similar among the cohorts ( p = 0.91). Grief severity was not correlated with demographic factors, physical presence in the final 48 h of life, intubation, or relationship with the deceased. Conclusion: Severe grief is common among family members bereaved during the COVID-19 pandemic, regardless of the cause or circumstances of death, and even if their loss took place before the onset of the pandemic. This suggests that aspects of the pandemic itself contribute to severe grief, and factors that normally mitigate grief may not be as effective.
Arterial input functions in dynamic susceptibility contrast MRI (DSC-MRI) in longitudinal evaluation of brain metastases
Authors: Starck Lea , Skeie Bente Sandvei , Bartsch Hauke , Grüner Renate 
Published: July 2022

Background Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) could be helpful to separate true disease progression from pseudo-progression in brain metastases when assessing the need for retreatment. However, the selection of arterial input functions (AIFs) is not standardized for analysis, limiting its use for this application. Purpose To compare population-based AIFs, AIFs specific to each patient, and AIFs specific to every visit in the longitudinal follow-up of brain metastases. Material and Methods Longitudinal data were collected from eight patients before treatment (6 of 8 patients) and after treatment (6–17 visits). Imaging was performed using a 1.5-T MRI system. Lesions were segmented by subtracting precontrast images from postcontrast images. Cerebral blood volume (rCBV) and cerebral blood flow (rCBF) were computed, and Pearson's product moment correlation coefficients were calculated to evaluate similarity of DSC parameters dependent on various AIF choices across time. AIF shape characteristics were compared. Parameter differences between white matter (WM) and gray matter (GM) were obtained to determine which AIF choice maximizes tissue differentiation. Results Although DSC parameters follow similar patterns in time, the various AIF selections cause large parameter variations with relative standard deviations of up to ±60%. AIFs sampled in one patient across sessions more similar in shape than AIFs sampled across patients. Estimates of rCBV based on scan-specific AIFs differentiated better between perfusion in WM and GM than patient-specific or population-based AIFs ( P ≤ 0.02). Conclusion Results indicate that scan-specific AIFs are the best choice for DSC-MRI parameter estimations in the longitudinal follow-up of brain metastases.
Hospital Variation in Mortality and Ventilator Management among Mechanically Ventilated Patients with ARDS
Authors: LeSieur Mallory N. , Bosch Nicholas A. , Walkey Allan J. 
Published: July 2022

Rationale Acute Respiratory Distress Syndrome (ARDS) is associated with significant mortality. Despite the mortality benefits of lung protective ventilation, adherence rates to evidence-based ventilator practice have remained low and ARDS mortality has remained high. Objective Determine variation in ARDS mortality and adherence to low tidal volume ventilation (LTV) across US hospitals. Materials and Methods We identified mechanically ventilated patients with ARDS using data from Philips eICU (2014-2015). We then used multi-variable hierarchical logistic regression models with hospital site as the random effect and patient and hospital level factors as fixed effects to assess the hospital risk adjusted mortality rate and median odds ratio for the association between mortality and hospital site. We then assessed associations between adherence to LTV (defined as 4-8 mL/kg PBW) and hospital risk adjusted mortality rates using Spearman correlation. Results Among 4441 patients admitted at 110 hospitals with ARDS, the hospital risk-adjusted mortality rate ranged from 19% to 39%, and the MOR for hospital of admission was 1.33 (95% CI 1.25-1.41). Among 3070 patients at 72 hospitals with available ventilator data, 73% of patients had a median set Vt between 4 to 8 mL/kg PBW; hospital adherence rates to LTV ranged from 13% to 95%. There was no association between hospital adherence to LTV and risk-adjusted mortality rate (spearman correlation coefficient −0.01, p = .93). Similarly, among 956 patients who started with a Vt > 8 mL/kg PBW, there was no association between the percent of patients at each hospital whose Vt was decreased to ≤ 8 mL/kg PBW and risk adjusted mortality rate (spearman correlation coefficient .05, p = .73). Conclusion Risk adjusted mortality and use of LTV for patients with ARDS varied widely across hospitals. However, hospital adherence to LTV was not associated with ARDS mortality rates. Further evaluation of hospital practices associated with lower ARDS mortality are warranted.
Quantification of longitudinal fastener stiffness and the effect on fastening system loading demand
Authors: Khachaturian Christian , Dersch Marcus S , Edwards J Riley , Trizotto Matheus 
Published: July 2022

Over the past 20 years, there have been at least 10 derailments due to spike fastener fatigue failures in North America. These fatigue failures have been considered a moderate to severe challenge that require manual walking inspections that are both time and labor intensive. These fatigue failures have been found to result from spike overloading due to lateral and longitudinal loads. To date, there has been limited quantification of the vertical, lateral, and longitudinal fastener forces in track. This paper quantifies the effect of fastener type on fastener load to account for various track types and locations. Laboratory experimentation was performed to quantify the stiffness of multiple fastening systems and this data was input into a previously validated analytical model to quantify the effect of stiffness on fastener loading. Additional laboratory experimentation was performed to quantify the relationships between both fastening system type and vertical loading and spike strain. While the laboratory data indicate a significant variance in stiffness between fastening systems, the model results indicate that the load transferred to the fastening system is less sensitive. However, spike strain data indicate the load path was affected by fastener type and vertical load. The characterization of longitudinal stiffness of multiple fastening systems and the relationship to spike load as presented can be used to advance track mechanistic-empirical design and improve rail neutral temperature prediction and track buckling models.
A Systematic Review of the Cost-Effectiveness of Cleft Care in Low- and Middle-Income Countries: What is Needed?
Authors: Chung Karen Y. , Ho George , Erman Aysegul , Bielecki Joanna M. , Forrest Christopher R. , Sander Beate 
Published: July 2022

Objective The objective of this paper is to conduct a systematic review that summarizes the cost-effectiveness of cleft lip and/or palate (CL/P) care in low- and middle-income countries (LMICs) based on existing literature. Design We searched eleven electronic databases for articles from January 1, 2000 to December 29, 2020. This study is registered in PROSPERO (CRD42020148402). Two reviewers independently conducted primary and secondary screening, and data extraction. Setting All CL/P cost-effectiveness analyses in LMIC settings. Patients, Participants In total, 2883 citations were screened. Eleven articles encompassing 1,001,675 patients from 86 LMICs were included. Main Outcome Measures We used cost-effectiveness thresholds of 1% to 51% of a country's gross domestic product per capita (GDP/capita), a conservative threshold recommended for LMICs. Quality appraisal was conducted using the Joanna Briggs Institute (JBI) checklist. Results Primary CL/P repair was cost-effective at the threshold of 51% of a country's GDP/capita across all studies. However, only 1 study met at least 70% of the JBI criteria. There is a need for context-specific cost and health outcome data for primary CL/P repair, complications, and existing multidisciplinary management in LMICs. Conclusions Existing economic evaluations suggest primary CL/P repair is cost-effective, however context-specific local data will make future cost-effectiveness analyses more relevant to local decision-makers and lead to better-informed resource allocation decisions in LMICs.
Supramalleolar Osteotomy for Ankle Varus Deformity Alters Subtalar Joint Alignment
Authors: Burssens Arne , Susdorf Roman , Krähenbühl Nicola , Peterhans Ursina , Ruiz Roxa , Barg Alexej , Hintermann Beat 
Published: July 2022

Background: Although correction of ankle and hindfoot deformity after supramalleolar osteotomy has been investigated extensively, the specific effect on the subtalar joint alignment remains elusive. This can be attributed to the limitations of 2-dimensional measurements, which impede an exact quantification of the 3-dimensional subtalar joint alignment. Therefore, we determined both the ankle, hindfoot, and subtalar joint alignment before and after supramalleolar osteotomy using autogenerated 3-dimensional measurements based on weightbearing CT imaging. Methods: Twenty-nine patients with a mean age of 50.4±10.6 years were retrospectively analyzed in a pre-post study design using weightbearing CT. Inclusion criteria were correction of ankle varus deformity by an opening wedge (n = 22) or dome osteotomy (n = 7). Exclusion criteria consisted of an additional inframalleolar arthrodesis or osteotomy. Corresponding 3-dimensional bone models were reconstructed to compute following autogenerated measurements of the ankle- and hindfoot alignment: tibial anterior surface (TAS), tibiotalar surface (TTS), talar tilt (TT) angle, hindfoot angle (HA). In addition, the talocalcaneal angle (TCA) in the axial (TCAax), sagittal (TCAsag), and coronal (TCAcor) plane were measured to assess the subtalar joint alignment. Results: The preoperative radiographic parameters of the ankle joint alignment (TAS=88±4 degrees, TTS=82±7 degrees, TT=5.8±4.9 degrees) improved significantly relative to their postoperative equivalents (TAS = 93±5 degrees, TTS = 88±7 degrees, TT=4.2±4.5 degrees; P < .05). The following radiographic parameters of the hindfoot and subtalar joint alignment improved significantly from preoperatively (8.7±8.9 degrees, TCAax = 41±10 degrees, TCAsag = 48±10 degrees) to postoperatively (HA=4.5±8.6 degrees, TCAax = 38±9 degrees, TCAsag = 44±11 degrees; P < .05). No significant differences could be detected in the coronal plane alignment of the subtalar joint (TCAcor) pre- compared to postoperatively ( P > .05). Conclusion: This study quantified the 3-dimensional ankle, hindfoot, and subtalar joint alignment after a solitary supramalleolar osteotomy. We found alterations in the subtalar joint alignment, which occurred by 2 to 3 degrees in each anatomic plane. However, before recommendations can be given related to inframalleolar procedures in conjunction to supramalleolar osteotomies, further studies on the variation of subtalar joint alignment change are needed.
Utilizing the balloon anchoring technique to improve device deliverability during stent revascularization for atherosclerotic renal artery stenosis
Authors: Huang Xiang , Li Xiao-Lan , Zhou Heng 
Published: July 2022

Introduction The stent revascularization for severely calcified renal artery lesions can be challenging, due to a deficiency in back-up force provided by the guide catheter. The aim of this report is to describe the use of the balloon anchoring technique to increase device maneuverability and deliverability after the failure of conventional renal artery revascularization. Technical note This technique was adopted in a patient with subtotal occlusive and severely calcified lesion in the proximal portion of the right main renal artery. Two guidewires were separately introduced into the proximal side branch (SB) and main branch (MB) of the renal artery. Anchor balloon inflated at low pressure in SB, anchoring the MB-wire and the guide catheter, thus giving us the ability to cross the tight calcified proximal cap of the MB lesion with a non-compliant balloon. After performing pre-dilatations and retrieving the anchor balloon, we implanted a balloon-expandable stent and achieved optimal final angiographic results. Conclusions The balloon anchoring technique can improve device maneuverability and deliverability during various catheterization procedures. Our report firstly demonstrates how to perform the balloon anchoring technique in renal angioplasty treatment and then explains its effectiveness in revascularization of the renal artery with challenging anatomies.