bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Advances In Environmental Sciences Removal Of Iron And Hexavalent Chromium Via Slow Sand Filter Inoculated With Thiobacillus Ferrooxidans
Authors: Mian Abrar hussain 
Published: May 2022

Abstract
Many places have common physical, biological, and chemical hazards and heavy metals contamination in drinking water is very important to study especially near industrial areas and mining sources. Application of microbes along with other physicochemical techniques can prove to be the suitable remediation technology for the removal of metals from water. This study aimed to remove iron and hexavalent chromium from water using slow sand filters inoculated with iron-oxidizing bacteria Acidothiobacillus ferrooxidans. An experiment was performed for 37 days under controlled conditions, a water sample was prepared synthetically and another sample was collected from water filtration plant from Abbottabad city in KP Province- Pakistan and influents and effluents were tested for different parameters like pH, turbidity, hardness, total plate count, total dissolved solids, electrical conductivity and analysis of iron and hexavalent chromium in water. Acidothiobacillus ferrooxidans culture was isolated from soil using the differential iron media i.e. 9K medium and was inoculated into sand filters. At the end of the experiment, the removal efficiency of ferrous iron was about 52% and that of hexavalent chromium was 60.2%. In simultaneous treatment, it was observed that removal efficiency of iron was about 68% while that of hexavalent chromium was about 93% suggesting that slow sand filters were more effective for the removal of hexavalent chromium than iron. Hence, the designed slow sand filters were able to reduce the concentration of hexavalent chromium more efficiently than ferrous iron. And it was observed that slow sand filters can effectively remove ferrous iron and hexavalent chromium from water if they are inoculated with respective bacteria.
Determinant The Frequency Of Short-Term Undesirable Events In Diabetes Discharged From The Emergency Department
Authors: Günsoy Ertuğ , Selman Fatma , Duyan Murat , Ünal Aslıhan Yürüktümen 
Published: May 2022

Abstract
ObjectivesIn our study, we aimed to reveal the frequency and determinants of adverse events in patients with diabetes mellitus, who presented to the emergency department for any reason, had uncomplicated hyperglycemia, but were decided to be treated as an outpatient.ResultsAs the patient group with a plasma glucose level of 200 mg/dl and above and normoglycemic diabetic patients were evaluated, no significant difference was found in terms of re-admission to the emergency department and the frequency of hospitalization. (Respectively, within seven days p=0.738, 0.805, within thirty days p=0.130, 0.697). In the patient group with plasma glucose level of 200 mg/dl and above, waiting times in the emergency department (p= 0.012) and average fluid replacement were higher (p=0.002). As the factors affecting re-admission were evaluated, it was found significant that the patient had insulin-dependent diabetes. (Within in seven days OR:2.20, %95 GA 1,.26-3.84, p = 0.005; within thirty days OR:2.48, %95 GA 1.39-4.41, p = 0.002). Other factors such as gender, age, admission glucose level and diabetes type were not found to be effective.ConclusionsThe high blood glucose level of diabetic non-complicated hyperglycemia cases admitted to the emergency department was not found to have an effect on recurrent admissions and hospitalizations for any reason in the first seven and thirty days. Treatment and follow-up planning should be done carefully in insulin-dependent diabetic patients with a high probability of re-admission and hospitalization in this group
The impact of patient navigation (PN) on timely access to radiotherapy in the Brazilian public health system
Authors: VIEIRA CAROLINA , Diniz Paulo , Dizon Don , Rodrigues Angélica Nogueira 
Published: May 2022

Abstract
Purpose: Considering the complex difficulties in accessing treatment, and the positive results of patient navigation (PN) in high income countries, it was decided to evaluate this tool to improve radiotherapy (RT) access in the public system in Brazil. Patients and methods: This pilot study was carried out in a public school hospital, with a historical cohort as the control arm.The primary endpoint was the time from histologic diagnosis and RT initiation among cancer patients receiving RT with curative intent in a PN program. The secondary objectives were the following time frames: referral to first consultation by RT team; first consultation up to RT beginning ; RT beginning to RT end; and identifying and describing the main obstacles to the treatment; and assessing patient satisfaction with PN program. Results: 124 patients were included in the retrospective arm and 73 in the navigation arm. Most had loco-regionally advanced disease from esophagus, head/ neck, and rectum. PN decreased the median time from biopsy result to the beginning of RT from 108 to 74 days (p < 0.001). PN also decreased the time between biopsy results and referral to RT (53 to 40.5 days, p = 0.011); between the referral and the first consultation in the RT (25 to 13 days, p < 0.001) and between the referral and the end of the RT (98 to 78 days, p < 0.003).Conclusions: Proper identification of barriers involved in treatment, especially in a low resource setting is mandatory in order to guide PN programs in LMICs. In an oncological context of socioeconomic vulnerability, PN is a financially viable and efficient tool to optimize access to timely RT.
Topological reorganization of functional hubs in Parkinson’s disease patients with freezing of gait.
Authors: Mishra Virendra , Sreeniva Karthik , Bayram Ece , Zhuang Xiaowei , Longhurst Jason , Yang Zhengshi , Cordes Dietmar , Ritter Aaron , Caldwell Jessica , Cummings Jeffrey , Mari Zoltan , Litvan Irene , Bluett Brent 
Published: May 2022

Abstract
Resting-state functional MRI (rs-fMRI) studies in Parkinson’s disease (PD) patients with freezing of gait (FOG) have implicated dysfunctional connectivity over multiple resting-state networks. While these findings provided information related to the aberrant or altered regional functional connectivity, whether these alterations have any effect on topological reorganization in PD-FOG patients is incompletely understood. In this study, we use rs-fMRI data and graph theoretical approaches to explore the reorganization of resting-state network topology in PD-FOG when compared to those without FOG (PD-nFOG). We found that the PD-FOG patients showed global topological reorganization accompanied by a reduction in efficiency and network strength. There was also a noticeable reorganization of ‘hub’ regions and significantly reduced rich-club connectivity in PD-FOG. Overall our findings demonstrate a widespread topological reorganization in PD-FOG which may further assist in improving our understanding of functional network disturbances associated with PD-FOG.
WITHDRAWN: Influence of Genetic Polymorphisms on the Pharmacokinetics and Safety of Nifedipine Controlled-release Tablets in Healthy Volunteers
Authors: Li Zhen , Wang Siyang , Ren Jian , Zhi Tingting , Wang Hongxia , Zhu Yuanyuan , Yao Zhiqing , Wang Yanhui , zhang huizi , zhang ruiqin 
Published: May 2022

Abstract
Background
Nifedipine is a calcium channel blocker, which is used to treat hypertension and angina pectoris. The present study aimed to evaluate the effects of gene polymorphisms on pharmacokinetics of relevant metabolic genes with inconsistent or incomplete research conclusions and of others that exhibited an impact on pharmacodynamics, so as to provide a scientific basis for the inter-individual variation in nifedipine controlled-release tablet disposition.
Methods
A total of 33 healthy volunteers were administered a single 30 mg oral dose of nifedipine controlled-release tablets, and were genotyped for 17 SNPs within 12 genes, by StepOne Real-Time PCR System and the Matrix-assisted laser desorption ionization-time of flight. The plasma concentration levels were quantified by Ultra-performance liquid chromatography tandem mass spectrometry. Univariate and multivariate analyses were performed and the mean pharmacokinetic variables were compared according to genotypes.
Results
The CYP3A4 rs2242480, ABCB1 rs1045642, CACNA1D rs312481, CACNA1C rs2238032, ACE rs4646994 and SLC14A2 rs3745009 polymorphisms significantly influenced the pharmacokinetics of nifedipine controlled-release tablets with a greater effect being noted on CACNA1D, CACNA1C, and SLC14A2. These results continued to be statistically significant following multivariate correction.
Conclusions
The CYP3A4 rs2242480, ABCB1 rs1045642, CACNA1D rs312481, CACNA1C rs2238032, ACE rs4646994 and SLC14A2 rs3745009 polymorphisms significantly influenced the pharmacokinetics of nifedipine controlled-release tablets. Their pharmacokinetic properties were examined, so as to provide a theoretical basis for individual differences found during treatment.
Randomized clinical trial quantifying the effectiveness of a self-monitoring intervention on cancer patients with peripheral neuropathy: Quantitative study
Authors: Kanda Kiyoko , Ishida Kazuko , Kyota Ayumi , Ishihara Chiaki , Fujimoto Keiko , Hosokawa Mai , Mochizuki Ruka 
Published: May 2022

Abstract
Purpose: Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a highly distressing condition that has no effective or helpful pharmacotherapy, alongside no established non-pharmacological treatment. Thus, there is an urgent need to develop supportive care. While self-monitoring has been verified as an effective management method, it has not been studied as a mode of managing CIPN. This study quantified the effectiveness of a self-monitoring intervention for the management of persistent CIPN. Methods: A randomized, controlled clinical trial was conducted wherein the participants were using Taxanes or platinum-based anticancer drugs in an outpatient setting. They were randomly assigned to either a control group (CG) (n=32) or a self-monitoring group (SMG) (n=33), wherein the participants recorded their symptoms daily, goals were set in collaboration with the researcher, and feedback (behavioral approval and modification, emotional support) was provided twice every three weeks. The study lasted for six weeks, and the control group received conventional nursing support. Self-management ability, self-efficacy, and Functional Assessment of Cancer Therapy-General (FACT-G) scores were used for evaluation; ANOVA analysis was conducted. Results: There was an interaction effect between the CG and SMG regarding self-efficacy scores. Scores were significantly higher in the SMG than in the CG after three weeks. Quality of life (QOL) scores were also higher in the SMG than in the CG. Conclusions: The self-monitoring intervention maintained the participants’ self-efficacy and QOL. This suggested its effectiveness on patients with peripheral neuropathy.Implications for Cancer Survivors: Self-monitoring interventions enable the maintenance of self-efficacy and QOL for participants associated with CIPN.Trail Registration: This research was registered with UMIN: Registration number (000028618).
Disrupting a socio-ecological system: How could traditional ecological knowledge be the key to preserving the Araucaria Forest in Brazil under climate change?
Authors: Tagliari Mario Muniz , Bogoni Juliano A. , Blanco Graziela D. , Cruz Aline P. , Peroni Nivaldo 
Published: May 2022

Abstract
Socio-ecological systems (SESs) hinge on human groups and ecosystems, promoting interdependence and resilience to environmental disturbances. Climate change effects propagate from organisms to biomes, likely influencing SESs. In southern Brazil, the Araucaria Forest is a typical SES due to the historical interaction between humans and biodiversity. Thus, we empirically and theoretically evaluated how climate change could disrupt this system by interviewing 97 smallholders and assessing their traditional ecological knowledge (TEK). We evaluated and measured the socioeconomic impact of the araucaria’s (Araucaria angustifolia) nut-like seed (pinhão) trade and the ethnoecological knowledge about climate change, as well as generated an ecosystem services network. We used these empirical data with a projected loss of 50–70% of the Araucaria Forest due to climate change to quantify the risks of the potential disruption of this SES. We found evidence that to avoid the disruption of the Araucaria Forests, it is paramount to value TEK holders, safeguard the historical socio-ecological interaction, and promote non-mutually exclusive measures in an integrative response to maintain the resilience of this forest to future disturbances.
The identification of copy number variations in upland cotton using a high-density SNP array
Authors: Ma QingShan , Tao ZhiXin , Du Xiao , Moming Maimaiti , Ai XianTao 
Published: May 2022

Abstract
Background
Upland cotton (Gossypium hirsutum) is one crucial natural textile fiber and oilseed crop worldwide. Copy number variation (CNV) represents a form of genomic structural variation underlying phenotypic diversity. Understanding the genomic CNVs of Upland cotton is important for accelerating cotton breeding programs.Therefore,the present study generated a CNV regions (CNVRs) map in Upland cotton using the SNP array-based approach. The roles of CNVs identified were explored based on GO enrichment analysis of genes located in CNVRs.
Results
we used the Illumina Cotton SNP 70K BeadChip array for genome-wide detection of CNVs in 288 Upland cotton accessions. A total of 341 CNVRs were detected, representing approximately 2.0% of the entire cotton genome. Of these, 264 were gains, 55 were losses, 22 were events with gains and losses within the same region. The average length of CNVRs was 125.5kb and the median length was 80.4kb.The gene ontology (GO) enrichment analysis revealed that genes associated with metabolic process, catabolic process, multiple enzyme activities and transcription regulator activity were significantly overrepresented.
Conclusions
The findings that 90.3% of CNVRs harbored genes indicated the critical roles of CNVs in cotton. we identified two intriguing candidate biological process terms, polysaccharide metabolic process and catabolic process, related to cotton fiber development. Our research characterized the first landscape of CNVRs in cotton, providing an important resource for investigations of cotton genetic variability. It will facilitate further researches of molecular mechanisms underlying CNV-associated traits and improve our knowledge of genomic structure of cotton.
Disentangling the impact of Atlantic Niño on sea-air CO2 flux
Authors: Koseki Shunya , Tjiputra Jerry , Fransner Filippa , Crespo Lander , Keenlyside Noel 
Published: May 2022

Abstract
The Atlantic Niño is a major tropical interannual climate variability mode of the sea surface temperature (SST) occurring during boreal summer that shares many similarities with the tropical Pacific El Niño. Although the tropical Atlantic is an important source of CO2 to the atmosphere, the impact of Atlantic Niño on the sea-air CO2 exchange is not well understood. We reveal that the Atlantic Niño enhances (weakens) CO2 outgassing in the central (western) tropical Atlantic. In the western basin, freshwater-induced changes in surface salinity, which considerably modulate the surface ocean CO2 partial pressure (pCO2), is the primary driver for the observed CO2 flux variations. Contrastingly, pCO2 anomaly in the central basin is dominated by the SST-driven solubility change. Here, we reveal that this multi-variable mechanism for pCO2 anomaly differs remarkably from the Pacific where the response is predominantly controlled by upwelling-induced dissolved inorganic carbon anomalies. The contrasting behavior is characterized by the high CO2 buffering capacity in the Atlantic, where the subsurface water mass contains higher alkalinity than in the Pacific. The different mechanisms driving the internannual variability in sea-air CO2 exchange in the tropical Atlantic and Pacific suggests that they may respond differently to climate change.
Decline of young-of-year walleye (Sander vitreus) growth due to Bythotrephes impacts predicted from bioenergetic principles
Authors: Gartshore Danni J , Rennie Michael D. 
Published: May 2022

Abstract
Invasive species are a major threat to ecosystem structure and function. For example, Bythotrephes cederströmii (Bythotrephes hereafter) invasions have significantly reduced native zooplankton density and biomass, resulting in competitive interactions with zooplanktivorous fishes. Young of year (YOY) walleye (Sander vitreus) are initially zooplanktivorous and have recently been shown to display reduced growth in Bythotrephes invaded lakes. Here, we combined a bioenergetics model for larval walleye with changes in the zooplankton community following Bythotrephes invasion and predicted reduced larval walleye growth in the presence of Bythotrephes, supporting field observations. The model predicted much greater impacts in oligotrophic versus mesotrophic lakes, whereby Bythotrephes invasion could potentially lead to walleye recruitment failure in low nutrient environments. As YOY growth, survival, and recruitment are ultimately linked to adult abundance and sustainability of managed stocks, our results highlight the potential impacts of Bythotrephes on the sustainability of walleye populations in boreal lakes.
Digital economy and environmental sustainability: How does ICT affect ecological footprint and what is the role of economic complexity?
Authors: Khan Asif , Ximei Wu 
Published: May 2022

Abstract
In the current era of digital economy, the role of information communication and technology and economic complexity are important for controlling environmental unsustainability and formulating policies to deal with ecological concerns. To inspects the impact of ICT and economic complexity on ecological footprint in G-seven (digital economies) countries from 2001–2018, in the current study we perform first generation as well as second generation unit root testing methods. Findings of both Pesaran’s and B&P’s cross-sectional dependence testing approaches confirms the presence of cross-sectional dependence across all G-seven economies. The empirical findings of cointegration (Pedroni and Kao) tests verify and stable long-run association between ecological footprint, ICT-import, ICT-export, economic complexity, economic growth and other control grouped variables. The empirical evidence obtained from Fully-Modified OLS model suggests that ICT export economic complexity, and economic growth enhance the intensity of ecological footprint, while ICT import, research and development (RD), and trade are helpful to reducing ecological footprint in G-seven economies. These empirical findings obtained from Fully-modified OLS models are also verified by Pooled Mean Group-ARDL(PMG-ARDL) methodologies and confirm that there is no inconsistency in the results. On the basis of these results, some policy implications for ecological footprint, ICT, and economic complexity are discussed.
Energy and exergy assessments of a large grid-connected PV installation under desert climatic conditions in Algeria
Authors: Aoun Nouar 
Published: May 2022

Abstract
In this study, a performance analysis of a 20 MW grid-connected PV plant located in Adrar in southern Algeria is carried out. Energetic and exergetic analyses of the PV plant have been performed. The results show that the annual energy produced by the PV system was 35892.2 MWh, ranging between 2725.16 and 3447.54 MWh in the months of July and March, respectively, which is close to the expected theoretical value of 36414 MWh. The annual average performance ratio of subsystems 1 and 2 and the PV plant are 72.6%, 70.83% and 71.71%, respectively. The annual average energy efficiency of subsystems 1 and 2 and the PV plant are 10.95%, 10.69% and 10.82%, respectively. The capture losses of the PV plant were higher and more than 1 h/d around the year. The annual monthly average exergy efficiency and thermal exergy were found to be 4.96% and 5.32 MW, respectively. The decrease in exergy efficiency values was matched by an increase in the values of thermal exergy loss, solar radiation, wind speed, and ambient temperature, where the thermal exergy loss has the highest effect. Similarly, the most influential environmental parameter on thermal exergy loss is solar radiation, with a determination coefficient of 80%.
Validity of the Spurling test in the diagnosis of cervical radiculopathy: A systematic review
Authors: Wang Ting , Wang Ting 
Published: May 2022

Abstract
BACKGROUND: Cervical radiculopathy (CR) is a common clinical presentation. The Spurling test is a commonly used provocative test for diagnosing cervical radiculopathy. Various diagnostic accuracy studies on the validity of the Spurling test have demonstrated high specificity but variable sensitivity.OBJECTIVE: This study aimed to find an evidence-based explanation for the variation in sensitivity of the Spurling test to assess the value of the Spurling test for clinical practice.STUDY DESIGN: A review of studies on the diagnostic validity of the Spurling test was conducted. The study sample comprised eight diagnostic accuracy studies of the Spurling test.OUTCOME MEASURES: Sensitivity, specificity, and likelihood ratios are presented.METHODS: A literature search of MEDLINE, EMBAS and PubMed was conducted through April 2022. The methodological quality of the studies was evaluated by Quality Assessment of Diagnostic Accuracy Studies (QUADAS).RESULTS: Eight diagnostic accuracy studies were selected, showing high specificity ranging from 74% to 98.5%, and the sensitivity varied from 14.7% to 95%. Studies that recruited surgical candidates showed a higher sensitivity, ranging from 92% to 95%. Studies that adopted the modified Spurling test maneuvres (incorporating neck extension, head rotation, and lateral neck bending) revealed a slightly higher sensitivity than those using only the lateral neck bending maneuvre. The inherent flaws of the reference standards may have altered the validity of the Spurling test.CONCLUSIONS: The value of the studies on the validity of the Spurling test has been undermined by multiple areas causing bias, such as patient spectrum difference, index test interpretation controversy, and a lack of gold reference standards. Spurling test use in clinical practice should be combined with patient history, careful selection of different Spurling variants, and other provocative tests to increase the diagnostic accuracy. Large-sample-size and well-validated studies on the accuracy of the Spurling test in diagnosing cervical radiculopathy are needed.