bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three-dimensional shape distribution of lunar regolith particles collected by the Apollo and Luna programs.
Authors: Tsuchiyama Akira , Sakurama Takashi , Nakano Tsukasa , Uesugi Kentaro , Ohtake Makiko , Matsushima Takashi , Terakado Kazuo , Galimov Erik M 
Published: August 2022

Abstract
The shapes of regolith particles on airless bodies, such as the Moon and asteroids, are important to understand their formation and evolution on surfaces. Limited studies have shown that the three-dimensional (3D) shapes of lunar regolith particles are, on average, more equant (spherical) than those of asteroid Itokawa or fragments by impact experiments. Therefore, more studies are required to determine whether such a feature is common. Accordingly, we performed X-ray microtomography imaging of lunar regolith particles collected by the Apollo program by NASA and the Luna program by the Soviet Union to obtain their 3D shapes. The ten samples (65 to 1108 particles/sample) examined had varieties of sampling sites (maria and highlands), reflecting the difference in materials (basalts and anorthosites, respectively, in general), regolith maturities, particle size ranges (< 74 to 450 mm), and petrographic textures (monomineralic, polymineralic, and agglutinate). The 3D particle shape distributions regarding three-axial length ratios (L:I:S, where L, I and S are the longest, intermediate, and shortest lengths, respectively) showed that the average three-axial ratios were almost similar among the samples, irrespective of the sampling sites, maturities, and the size ranges [S/I = 0.769(8), I/L = 0.755(10), and S/L = 0.579(11) for whole samples]. The 3D shapes of lunar particles were more equant (spherical) than those of the particles collected from asteroid Itokawa and fragments by hypervelocity impact experiments which had the average ratios similar to the 2D silver ratio (S/I = I/L = 0.707 and S/L = 0.500). These findings showed that the balance between impact fragmentation and mechanical abrasion controls the 3D shapes of lunar particles because impact and particle motion on the Moon’s surface occur for a longer duration; however, impact fragmentation on this small asteroid surface primarily controls those of Itokawa particles.
The Effect of Systemic Administration of Zinc on The Gingival Crevicular Fluid Level of Total Oxidant Capacity in Type 2 Diabetic Patients with Stage II and III Periodontitis After Non-Surgical Periodontal Therapy: A Randomized Clinical Trial
Authors: Alqawi Abdulrahman A. , Mahmoud Enji A. , Darhous Mona S. , Shaker Olfat Gamil , Elbattawy Weam 
Published: August 2022

Abstract
Objectives: This study aimed to evaluate the effect of systemic administration of zinc supplementation on the total oxidant capacity in the gingival crevicular fluid level of controlled type 2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal therapy.Materials and Methods: This clinical trial was registered at ClinicalTrials.gov Identifier: ID: NCT03923829 on April 23, 2019. Twenty-eight controlled type 2 diabetic patients with periodontitis stages II or III were randomly assigned into two groups, test and control where both received non-surgical periodontal therapy while the test group received 50 mg zinc one tablet/day for 12 weeks. Total oxidant capacity (TOC) level was measured in GCF of both groups at baseline and after 3 months. HbA1c level, GI, PPD and CAL were also reported at baseline and 3 months postoperatively.Results: After 3 months a statistically significant decrease in mean TOC µmol/L was reported in both groups being more significantly lower in test group. No significant difference in mean percentage HbA1c was reported after 3 months neither within each group nor between the two groups. In both groups there was a significant reduction in GI scores, PPD reduction and CAL gain after 3 months with no significant difference between them, while the test group showed significantly lower GI than the control group.Conclusions: Systemic administration of zinc supplements as an adjunct to non-surgical periodontal therapy might improve the clinical parameters and oxidative stress in T2DM patients with stage II-III periodontitis.Clinical Relevance:Zinc supplements can be an effective adjunct to nonsurgical periodontal therapy in type 2 diabetic patients with stages II or III periodontitis.
The Relationship between Behavioral and Mood Responses to Monetary Rewards in a Sample of Indian Students with and without Reported Pain
Authors: Tandon Tanya , Piccolo Mayron , Ledermann Katharina , Gupta Rashmi , Morina Naser , Martin-Soelch Chantal 
Published: August 2022

Abstract
Physical pain has become a major health problem among university students; many are affected by it each year worldwide. Several studies have examined the prevalence of pain-related impairments in reward processing in Western, Educated, Industrialized, Rich, and Democratic (WEIRD) countries and very often fail to replicate findings in non-western cultural settings. Here, we aimed to investigate the prevalence of physical pain symptoms in a sample of university students in India and replicate our previous study conducted on university students in Switzerland that showed reduced mood and behavioral responses to reward in students with significant pain symptoms. We divided the students into a sub-clinical group (N = 40) and a control group (N = 48) to test the influence of pain symptoms on reward processes. We used the Fribourg reward task and the pain sub-scale of the Symptom Checklist (SCL-27-plus) to assess the physical symptoms of pain. We found that 45% of the students reported high levels of physical symptoms of pain and interestingly, our ANOVA results did not show any significant interaction between reward and the groups neither for mood scores nor for the outcomes related to performance. These results might yield the first insights that pain-related impairment is not a universal phenomenon and can vary across cultures.
Four shades of red: optimizing the use of oviposition traps to monitor mosquito populations of arbovirus vectors in La Reunion
Authors: Brouazin Ronan , Claudel Iris , Lancelot Renaud , Dupuy Guillaume , Gouagna Louis-Clément , Dupraz Marlène , Baldet Thierry , Bouyer Jérémy 
Published: August 2022

AbstractRecently, several epidemics caused by mosquito-borne viruses - including dengue viruses (DV) have occurred in La Reunion and other Indian Ocean islands.Aedes albopictusandAe. aegypti- two important DV vectors, co-occur in La Reunion.Aedes albopictusis the major DV vector, preponderant and widespread in the island.Aedes aegyptiis localized in certain areas and shows a peculiar ecology, compared to other tropical populations of the same species. This study aimed at providing users (researchers, mosquito control operators, health managers) with a locally-validated oviposition traps (ovitraps) to monitorAedespopulations.A field experiment was achieved in Saint-Joseph - where both mosquito species occur in sympatry, to assess the effect of different ovitrap settings on their detection probability and apparent density. Preliminary surveys indicated black plastic ovitraps were the best traps. Vacoa trees (Pandanus utilis) were the only observed breeding sites forAe. aegypti, shared withAe. albopictus. They were the experimental units in a design considering three factors: trap position in the trees (ground vs canopy), the oviposition surface used in the trap (blotting paper vs. vacoa leaf), and addition of organic matter (fish food) to the trap water.The addition of organic matter to trap water was not an important factor in this study. On the ground,Ae. aegyptieggs were only found when vacoa leaves were used for oviposition. Their detection and apparent density increased greatly when ovitraps were located in the tree canopy. The main factor forAe. albopictuswas the oviposition surface, with a strong preference for blotting paper. However, with vacoa leaves, the detection was also close to 100%. Further laboratory studies indicated larvae survival was lower for a high egg density, combined with blotting paper as the oviposition surface.When monitoring mixedAedespopulations in La Reunion, we recommend the use of black plastic ovitraps, filled with tap water, placed at 1.50-to-2.00-m high in vacoa trees, with vacoa leaves as the oviposition surface.
State-dependent alternations of implicit emotional dominance during binocular rivalry in subthreshold depression
Authors: Qiu Shiming , Luo Xu , Luo Yuhong , Wei Dandan , Mei Gaoxing 
Published: August 2022

Abstract
Background: Binocular rivalry, a phenomenon that individuals often experience back-and-forth perceptual alterations when two distinct monocular stimuli are presented to each eye simultaneously, has been reported as a biomarker in several psychiatric disorders. It is unclear whether abnormalities of binocular rivalry in depression could exist when emotional rivaling stimuli are used, and if so, whether the emotional binocular rivalry test could provide a trait-dependent biomarker or a state-dependent biomarker.Methods: Thirty-four individuals with subthreshold depression and thirty-one non-depressed individuals were recruited to perform a binocular rivalry task including implicit emotional processing. The participants were required to report their perceived orientations of the rival gratings in the foreground and simultaneously to neglect emotional face stimuli in the background. The participants were retested after an approximately 4-month time interval.Results: Compared to the non-depressed group, the depressive group showed significantly stronger implicit emotional dominance at the initial assessment. However, the abnormality was not observed at the follow-up assessment. More importantly, individuals displaying stronger emotional dominance at the initial assessment were more difficult for improvement in depressive severity at the follow-up assessment. No difference was found regarding the switching rate between the depressive group and the non-depressed controls.Conclusions: The abnormality on emotional dominance for individuals with subthreshold depression is associated with depressive symptoms over time. The current emotional binocular rivalry test may provide an objective state-dependent biomarker for distinguishing depressive individuals from healthy individuals.
The debate on the earthquake magnitude correlations: A meta-analysis
Authors: Petrillo Giuseppe , Zhuang Jiancang 
Published: August 2022

Abstract
Among the most important questions that await an answer in seismology, perhaps one is whether there is a correlation between the magnitudes of two successive seismic events. The answer to this question is considered of fundamental importance given the potential effect in forecasting models, such as Epidemic Type Aftershock Sequence (ETAS) models. After a meta-analysis of 29 papers, we speculate that given the lack of studies carried out with realistic physical models and given the possible bias due to the lack of events recorded in the experimental seismic catalogs, important improvements are necessary on both fronts to be sure to provide a statistically relevant answer.
Surface-coated polymer nanocomposites containing z-aligned high-k nanowires as high-performance dielectrics at elevated temperatures
Authors: Cheng Sang , Li Yushu , Yang Mingcong , Fu Jing , Wang Rui , Hu Jun , He Jinliang , Li Qi 
Published: August 2022

Abstract
Recently, demands for high-performance polymer film capacitors at elevated temperatures have become more urgent. High dielectric constant is essential for dielectric materials to achieve substantial energy density at relatively low electric fields, which is of great significance to practical applications, while improving the permittivity of high-temperature polymer dielectrics without a remarkable deterioration in other electrical properties still remains a challenge. Here, a polymer nanocomposite containing z-aligned high-k nanowires sandwiched by e-beam evaporation deposited Al2O3 films was developed on account of the optimal structure proposed by the phase-field simulation. It is found that z-aligned nanowires are more effective in promoting the dielectric constant than random-aligned ones and a large increase in dielectric constant is observed at relatively low content of nanofillers. Outer insulating layers effectively suppress the electric conduction and improve the breakdown strength. Consequently, the nanocomposite with only 1 volume fraction of z-aligned nanowires exhibits a breakdown strength, electrical resistance and charge-discharge efficiency as high as neat PEI, but more than twice the discharged energy density than it at 150 °C. This work realizes the optimal structure predicted by simulation in experiment, obtaining high-permittivity high-temperature nanocomposites at no expense of other electrical properties and making it possible to achieve high discharged energy density at relatively low electric fields.
WITHDRAWN: Electrospun Pullulan-based Nanofibers to Prepare Modified Electrodes for Electrochemiluminescence Detection of Azithromycin
Authors: Wang Tongfei , Zhang Liwen , Li Xuenuan , Li Tianhao , Qin Danfeng , Tang Tingfan , Feng Jun , Cheng Hao 
Published: August 2022

Abstract
In this paper, a bio-based carbon nanofibers material was prepared by electrospinning, and carbon fiber was further prepared with pullulan as the carbon source and nitrogen source, and a new type of string-shaped bio-based carbon nanofiber was prepared. Using scanning electron microscopy, EDS Energy Dispersive Spectrometer, XPS X-ray photoelectron spectroscopy and XRD X-ray Diffraction to detect and analyze the morphology structure and elements of the material, the above characterization results show that the pullulan-based nanofibers have crossover Type 3D fiber structure. The composite material elements are mainly composed of C elementsand O elements. The pullulan-based carbon nanofiber material can be used for the Electrochemiluminescence detection of azithromycin and exhibits high sensitivity. The detection range of this modified electrode for azithromycin is 1×10− 7-1×10− 4 µmol/L, and the linear correlation coefficient R2 = 0.996. The lower limit of detection (LOD) is 9×10− 8 µmol/L.The standard recovery rate of 10, 50, 70 µmol/L is 99.32–100.31%. Relative standard deviation is less than 5%, This method has good selectivity and high sensitivity, and can be used for the detection of azithromycin.
Clinical presentation, viral kinetics and management of human monkeypox cases from New Delhi, India 2022
Authors: Relhan Vineet , Sahay Rima R. , Shete Anita M. , Choudhary Aashish , Yadav Pragya D. , Sahoo BL , Brijwal Megha , Patil Deepak Y. , Kumar Suresh , PS Kannan Sabarinath , Mohandas Sreelekshmy , Abraham Priya 
Published: August 2022

Abstract

We describe the clinico-demographical, virological follow-up and management of five confirmed Monkeypox cases from New Delhi, India without any international travel history. The viral load kinetics and viral clearance was estimated in oropharyngeal swab (OPS), nasopharyngeal swab (NPS), EDTA blood, serum, urine and various lesion specimens at every fourth day of follow-up ranging from 5-24 post onset day (POD) of illness. All the five cases presented with mild to moderate grade intermittent fever, myalgia and lesions on the genitals, groins, lower limb, trunk and upper limb. Four cases had non-tender firm lymphadenopathy. No secondary complications or sexually transmitted infections were recorded in these cases except for HBV in one case. All the cases were mild and had good recovery. The high viral load was detected at POD 14 in lesion fluid, followed by lesion roof at POD 5, lesion base at POD 14 while urine, OPS and NPS at POD 5. The MPXV DNA was detected from 5 to 24 POD. These Monkeypox cases suggests the under diagnosed monkeypox infection in the community. This emphasizes the need for active surveillance of MPXV in high-risk population such as Men having sex with men (MSM) and female sex workers (FSW).
Distributional regression data analysis across different race/ethnic groups and poverty levels in the US adult population
Authors: Matabuena Marcos , Stamatakis Emmanuel , Petersen Alexander , Padilla Oscar Hernán Madrid , Cruz Borja del Pozo 
Published: August 2022

Abstract
Disparities in physical activity may contribute to the well-known racial/ethnic and poverty gaps in health and well-being (Winkleby et al. 1998). Recent developments in wearable technologies enable the continuous recording, at a high resolution, of the amount and intensity of physical activity performed by an individual over a period of time. Unlike previous self-reported (mostly leisure time) physical activity evidence (Saffer et al. 2013; Dogra, Meisner, and Ardern 2010), monitoring the full continuum of device-based physical activity intensity can help uncover critical information to plan, implement, and evaluate public health initiatives that promote evidence-based practice and policy, particularly among at-risk populations that would most benefit. Capitalizing on a representative sample of the US population who wore wrist accelerometers, this study examined the impact of race/ethnicity and poverty on detailed functional representations of device-based physical activity.
Limited sampling strategies for individualized BAX 855 prophylaxis in severe hemophilia A: in silico evaluation
Authors: Bukkems L.H. , Goedhart M.H.J. , Zwaan C. M. , Cnossen M. H. , Mathôt R. A.A. 
Published: August 2022

Abstract
PurposeLimited sampling strategies (LSS) lower the burden of PK-guided dosing, but an extensive evaluation of LSS for BAX 855 (Adynovi®) is currently lacking. This study aimed to develop a LSS for BAX 855 and combine this with a LSS of a standard half-life (SHL) FVIII concentrate in a clinical setting. MethodsIndividual PK parameters of BAX 855 were estimated for 10,000 virtual patients with severe hemophilia A using Monte Carlo simulations. Several LSS consisting of 2-6 samples were examined based on patient burden, bias and accuracy of clearance, elimination half-life, volume of distribution and trough levels at 72h (C72). Analyses were performed separately for adults and children <12 years.ResultsThe preferred LSS for BAX 855 consisted of three sampling points at 15-30 min, 48h and 72h for both adults (mean accuracy C72: 14.0% vs. 10.8% using six samples) and children (mean accuracy C72: 14.9% vs. 11.4% using six samples). The best strategy with two samples (peak, 48 hours) resulted in an adequate, but lower accuracy than strategies with ≥3 samples (mean accuracy C72: 22.3%). The optimal combination of the LSS of SHL FVIII and BAX 855 led to six samples during four clinical visits.ConclusionThis in silico study has identified that two to three samples are necessary to estimate the individual PK of BAX-855 adequately. These samples can be collected in one or two clinical visits. When combining PK profiling of SHL FVIII and BAX 855, six samples during four clinical visits are needed.
The bioinformatics and experimental analysis of CD276 for prognosis and immune infiltrates in colon adenocarcinoma
Authors: Chen Rui , Chai Chen , Ma Shoucheng , Guan Quanlin , Wu Dongjin 
Published: August 2022

Abstract
BackgroundColon adenocarcinoma (COAD), although the third-most common type of gastrointestinal tumors, still lacks specific biomarkers for early diagnosis, treatment, and prognosis. CD276, an immune checkpoint, is upregulated in various cancers.This study aimed to evaluate the role of CD276 in tumorigenesis, prognosis and immunity for COAD.MethodsThe expression profile of CD276 gene in COAD was established by using RNA-sequencing transcriptomic data of The Cancer Genome Atlas (TCGA) databases. The biological functions of CD276 were evaluated using the Metascape database and Gene Set Enrichment Analysis (GSEA). The association between CD276 and immune cell infiltration was investigated by TIMER website. Correlation analysis was performed between CD276 expression and clinicopathological characteristics. Cox proportional hazard regression and Kaplan-Meier final analysis were applied for identifying the prognostic role of CD276. ResultsCD276 expression was significantly elevated in COAD tumor (P < 0.0001). Functional annotation revealed many enriched GO-terms among which the activity of the growth factor, cell adhesion and corresponding cancer-related pathways were highly represented in high CD276 expression phenotype. High CD276 was associated with microsatellite instability (MSI) status, patients’ survival, and disease progression. Cox regression analysis revealed that CD276 was a risk factor for overall survival [hazard ratio (HR): 1.848, P = 2.64E−03], disease-specific survival (HR: 2.406, P = 5.35E−04), and progression-free interval (HR: 1.772, P = 2.04E−03). Moreover, CD276 level was significantly associated with tumor immune cell infiltration, biomarkers of immune cells, and immune checkpoint expression.ConclusionsOur analyses indicated that increased CD276 may contribute to COAD development by activing tumor‐promoting signal pathways and altering the immune microenvironment. It is believed that abnormal expression of CD276 has clinical prognostic value in COAD patients.
Screening and identification of azacyclonol and fexofenadine in human urine using LC–MS/MS
Authors: Saito Takeshi , Namera Akira , Yamamoto Rie , Tsuji Tomoatsu , Morita Seiji , Nakagawa Yoshihide 
Published: August 2022

Abstract
Azacyclonol metabolized from fexofenadine and pipradrol are structural isomers and are important biomarkers to determine fexofenadine or pipradrol intake. Detecting these two analytes by liquid chromatography–mass spectrometry (LC–MS) allows for their differentiation from structurally similar compounds. This study aimed to confirm the separation of azacyclonol and pipradrol through different chromatographic conditions in LC–MS. Urine samples were prepared by HLB and were separated in a high-performance reversed phase column. MS detection was achieved using a triple quadrupole mass spectrometer in positive ionization modes. Azacyclonol and pipradrol were differentiated by optimizing the gradient profile using LC–MS. We used a common Poroshell C18 column with acetonitrile and 0.1% acetic acid solution. Azacyclonol and fexofenadine were detected in the urine of patients who took fexofenadine. Fexofenadine is an important biomarker for the determination of azacyclonol and piradrol. LC–MS has been the dominant analytical technology for the quantitative bioanalysis of drugs and metabolites. Although some analytes do not require sufficient separation by LC according to selectivity by LC–MS, sufficient separation by LC is required for the separation of such position isomers.
Moxibustion regulates hypothalamic microglia M1-M2 polarization to against the aging of GnRH neurons
Authors: He Xinlu , Li Yi , Wang Qiang , Li Long , Li Xuezhi 
Published: August 2022

Abstract
With the current increase in population aging, anti-aging has become a popular area of current medical research. Previous studies have found that hypogonadotropin-releasing hormone (GnRH) secretion in the hypothalamus is an important factor in multi-organ aging, and GnRH secretion and receptor levels are influenced by the intrahypothalamic environment. Therefore, using a 20-month-old natural aging rat model, we found no significant difference between moxibustion treatment in improving physiological status and serum sex hormone levels in aged rats compared with exogenous sex hormone supplementation. In contrast, moxibustion was found to promote the polarization of hypothalamic microglia by immunofluorescence double-labeling and PCR, thus promoting the activation of GnRH neurons and the secretion of GnRH. western blot analysis showed that it decreased the levels of inflammatory factors IL-1β and IL-12, increased the levels of anti-inflammatory factors and neurotrophic factors TGF-β, IL-10, and GDNF, and improved the hypothalamic In conclusion, moxibustion can regulate the polarization of hypothalamic microglia and thus promote the activation of GnRH neurons to slow down aging.