bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracking the Cracking: A Holistic Analysis of Rapid Ice Shelf Fracture Using Seismology, Geodesy, and Satellite Imagery on the Pine Island Glacier Ice Shelf, West Antarctica
Authors: Olinger S. D. , Lipovsky B. P. , Denolle M. A. , Crowell B. W. 
Published: May 2022

AbstractIce shelves regulate the stability of marine ice sheets. We track fractures on Pine Island Glacier, a quickly accelerating glacier in West Antarctica that contributes more to sea level rise than any other glacier. Using an on‐ice seismic network deployed from 2012 to 2014, we catalog icequakes that dominantly consist of flexural gravity waves. Icequakes occur near the rift tip and in two distinct areas of the shear margin, and TerraSAR‐X imagery shows significant fracture in each source region. Rift‐tip icequakes increase with ice speed, linking rift fracture to glaciological stresses and/or localized thinning. Using a simple flexural gravity wave model, we deconvolve wave propagation effects to estimate icequake source durations of 19.5–50.0 s and transient loads of 3.8–14.0 kPa corresponding to 4.3–15.9 m of crevasse growth per icequake. These long‐source durations suggest that water flow may limit the rate of crevasse opening.
Nitrogen Retention in Feldspar: Implications for Nitrogen Transport in Subduction Zones
Authors: Yang Yan , Huang Weihua , Qi Zeming , Xia Qunke 
Published: May 2022

AbstractNitrogen recycling between Earth's interior and exterior determines the evolution of the atmosphere and habitability of the planet. However, the contribution of subduction to the deep nitrogen recycling is still highly debated. Ammonium‐bearing silicate minerals are the main nitrogen carriers in subduction zones. Nitrogen retention in subduction‐zone minerals determines the subducted nitrogen fluxes to the deep Earth. Here, we reveal ammonium behavior in a natural ammonium‐bearing feldspar at elevated temperatures to 1000°C and pressures to 19.99 GPa. With increasing temperature and pressure, ammonium interacts with the silicate framework and forms hydrogen bonding. The ammonium loss rates are on the order of 10−15, 10−14, and 10−13 at 800, 900, and 1000°C, respectively, with activation energy of 271 ± 13 kJ/mol. The activation energy of ammonium loss in feldspar is higher than that in phengite. Moreover, the ammonium diffusivities are similar to that of hydrogen in feldspar, but much slower than that of molecular water and faster than those of K and Ar. The results imply that most of nitrogen can be potentially retain in the feldspar structure before feldspar breakdown. Considering that feldspar could be stable to a great depth along cold subduction, it could be a potential carrier for nitrogen transport to the deep Earth.
Validation of Repetitive Volcanoseismic Signals in Aso Volcano, Japan With Distant Stations: Implications of Source Characterization and Remote Sensing in Uninstrumented Volcanoes
Authors: Niu Jieming , Song Teh‐Ru Alex 
Published: May 2022

AbstractRepetitive volcanoseismic signals, including very‐long‐period signals (VLP) and long‐period signals (LP), provide a unique probe of fluid transport processes inside magmatic‐plumbing system. While syneruptive signals are often detected and analyzed with regional or/and global seismic networks to retrieve eruption location and mechanism, repetitive noneruptive volcanoseismic signals are generally small, and they are typically detected with in situ stations near the volcanic edifices. Here, we show that repetitive VLP and synchronous deformation events in Aso volcano, Japan, can be detected in the high (15–30 s) and low (50–100 s) VLP bands, respectively, at seismic stations located ∼30–1,000 km away from their sources. Changes in the polarities, phases, and amplitudes of VLP and synchronous deformation events observed at the in situ stations can be verified by the seismic waves in the two VLP bands, respectively, at distant stations up to 150 km. Forward modeling of the amplitude decay in the two VLP bands against epicentral distance corroborates the source locations previously determined by the in situ data, whereas the joint data analysis of in situ and distant stations at high VLP band suggests the presence of single‐force component (i.e., force/moment ratio of 10−4 m−1) in the source of VLPs. We advocate that not only can systematic data mining against established global and regional seismic networks potentially expand the detection capability of repetitive volcanoseismic signals backward in time when in situ observations were unavailable, but it could also substantially improve the detection and monitoring capacity in otherwise uninstrumented volcanoes, complementary to remote sensing of ground deformation.
High‐Resolution 3D Shallow S Wave Velocity Structure of Tongzhou, Subcenter of Beijing, Inferred From Multimode Rayleigh Waves by Beamforming Seismic Noise at a Dense Array
Authors: Qin Tongwei , Lu Laiyu , Ding Zhifeng , Feng Xuanzheng , Zhang Youyuan 
Published: May 2022

AbstractThe 3D S wave velocity of shallow structures, especially the quaternary sediments at 0–1 km near the surface, is an important issue of concern in urban planning and construction for seismic hazard assessment and disaster mitigation. Due to the facility and less dependence on the site environment, noise‐based technique is an ideal way to acquire the fine structure of urban sedimentary basin. Based on the dense array composed of more than 900 stations deployed in Tongzhou at a local scale of 20 × 40 km2, we prove that the lateral variation of the phase velocity of multimode surface waves can be estimated directly with sufficient accuracy by beamforming seismic noise with moving subarrays. Rayleigh wave phase velocity maps, at frequencies between 0.3 and 2.5 Hz for the fundamental mode as well as 0.8 and 3.0 Hz for the first overtone, are obtained. The 3D S wave velocity model at 0–1‐km depth with lateral resolution of 1 km is then established by inverting phase velocity maps of the two modes. The sediment thickness is delineated by the impedance interface given by microtremor H/V (horizontal‐to‐vertical) spectral ratio. The proposed model is in good agreement with the distribution of tectonic units. The sediment thickness of Daxing high and two sags around Gantang and Xiadian are, respectively, 100–400 and 400–600 m, which correlates well with the 1 km/s isosurface of S wave velocity. The model presents some evidence on the extension of Daxing fault along NE direction.
Ganymede's Ionosphere Observed by a Dual‐Frequency Radio Occultation With Juno
Authors: Buccino D. R. , Parisi M. , Gramigna E. , Gomez‐Casajus L. , Tortora P. , Zannoni M. , Caruso A. , Park R. S. , Withers P. , Steffes P. , Hodges A. , Levin S. , Bolton S. 
Published: May 2022

AbstractIn June 2021, the Juno spacecraft executed a close flyby of Ganymede. During the encounter, Juno passed behind Ganymede for 15 min as observed from Earth, providing the geometry to conduct a radio occultation experiment to probe Ganymede's tenuous ionosphere. X‐band and Ka‐band radio links were transmitted from Juno to antennas at the Deep Space Network. Electrons encountered along the radio propagation path advance the signal's phase and a linear combination the two frequencies allows for a direct measurement of the electron content along the propagation path. On occultation ingress, an ionosphere peak of 2,000 ± 500 (1‐σ) cm−3 near the surface was observed. On occultation egress, no statistically significant ionosphere was detected. Ingress observation viewed where Ganymede's intrinsic magnetic field lines are open whereas egress observation viewed where the field lines are closed, implying electron impact ionization plays a key role in the generation of the ionosphere.
Estimating the benefits of obesity prevention on productivity: an Australian perspective
Authors: Menon Kirthi , de Courten Barbora , Ademi Zanfina , Owen Alice J. , Liew Danny , Zomer Ella 
Published: May 2022

Abstract
Background/objectives
Obesity poses one of the biggest public health challenges globally. In addition to the high costs of obesity to the healthcare system, obesity also impacts work productivity. We aimed to estimate the benefits of preventing obesity in terms of years of life, productivity-adjusted life years (PALYs) and associated costs over 10 years.

Subjects/methods
Dynamic life table models were constructed to estimate years of life and PALYs saved if all new cases of obesity were prevented among Australians aged 20–69 years from 2021 to 2030. Life tables were sex specific and the population was classified into normal weight, overweight and obese. The model simulation was first undertaken assuming currently observed age-specific incidences of obesity, and then repeated assuming all new cases of obesity were reduced by 2 and 5%. The differences in outcomes (years of life, PALYs, and costs) between the two modelled outputs reflected the potential benefits that could be achieved through obesity prevention. All outcomes were discounted by 5% per annum.

Results
Over the next 10 years, 132 million years of life and 81 million PALYs would be lived by Australians aged 20–69 years, contributing AU$17.0 trillion to the Australian economy in terms of GDP. A 5% reduction in new cases of obesity led to a gain of 663 years of life and 1229 PALYs, equivalent to AU$262 million in GDP.

Conclusions
Prevention of obesity is projected to result in substantial economic gains due to improved health and productivity. This further emphasises the need for public health prevention strategies to reduce this growing epidemic.
Materials synthesis at terapascal static pressures
Authors: Dubrovinsky Leonid , Khandarkhaeva Saiana , Fedotenko Timofey , Laniel Dominique , Bykov Maxim , Giacobbe Carlotta , Lawrence Bright Eleanor , Sedmak Pavel , Chariton Stella , Prakapenka Vitali , Ponomareva Alena V. , Smirnova Ekaterina A. , Belov Maxim P. , Tasnádi Ferenc , Shulumba Nina , Trybel Florian , Abrikosov Igor A. , Dubrovinskaia Natalia 
Published: May 2022

AbstractTheoretical modelling predicts very unusual structures and properties of materials at extreme pressure and temperature conditions1,2. Hitherto, their synthesis and investigation above 200 gigapascals have been hindered both by the technical complexity of ultrahigh-pressure experiments and by the absence of relevant in situ methods of materials analysis. Here we report on a methodology developed to enable experiments at static compression in the terapascal regime with laser heating. We apply this method to realize pressures of about 600 and 900 gigapascals in a laser-heated double-stage diamond anvil cell3, producing a rhenium–nitrogen alloy and achieving the synthesis of rhenium nitride Re7N3—which, as our theoretical analysis shows, is only stable under extreme compression. Full chemical and structural characterization of the materials, realized using synchrotron single-crystal X-ray diffraction on microcrystals in situ, demonstrates the capabilities of the methodology to extend high-pressure crystallography to the terapascal regime.
Genetic and chemotherapeutic influences on germline hypermutation
Authors: Kaplanis Joanna , Ide Benjamin , Sanghvi Rashesh , Neville Matthew , Danecek Petr , Coorens Tim , Prigmore Elena , Short Patrick , Gallone Giuseppe , McRae Jeremy ,   Genomics England Research Consortium, Moutsianas Loukas , Odhams Chris , Carmichael Jenny , Barnicoat Angela , Firth Helen , O’Brien Patrick , Rahbari Raheleh , Hurles Matthew 
Published: May 2022

AbstractMutations in the germline generates all evolutionary genetic variation and is a cause of genetic disease. Parental age is the primary determinant of the number of new germline mutations in an individual’s genome1,2. Here we analysed the genome-wide sequences of 21,879 families with rare genetic diseases and identified 12 individuals with a hypermutated genome with between two and seven times more de novo single-nucleotide variants than expected. In most families (9 out of 12), the excess mutations came from the father. Two families had genetic drivers of germline hypermutation, with fathers carrying damaging genetic variation in DNA-repair genes. For five of the families, paternal exposure to chemotherapeutic agents before conception was probably a key driver of hypermutation. Our results suggest that the germline is well protected from mutagenic effects, hypermutation is rare, the number of excess mutations is relatively modest and most individuals with a hypermutated genome will not have a genetic disease.
High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets
Authors: MacMillan Hannah J. , Kong Yahui , Calvo-Roitberg Ezequiel , Alonso Laura C. , Pai Athma A. 
Published: May 2022

AbstractThe antisense non-coding RNA in the INK locus (ANRIL) is a hotspot for genetic variants associated with cardiometabolic disease. We recently found increased ANRIL abundance in human pancreatic islets from donors with certain Type II Diabetes (T2D) risk-SNPs, including a T2D risk-SNP located within ANRIL exon 2 associated with beta cell proliferation. Recent studies have found that expression of circular species of ANRIL is linked to the regulation of cardiovascular phenotypes. Less is known about how the abundance of circular ANRIL may influence T2D phenotypes. Herein, we sequence circular RNA in pancreatic islets to characterize circular isoforms of ANRIL. We identify several consistently expressed circular ANRIL isoforms whose expression is correlated across dozens of individuals and characterize ANRIL splice sites that are commonly involved in back-splicing. We find that samples with the T2D risk allele in ANRIL exon 2 had higher ratios of circular to linear ANRIL compared to protective-allele carriers, and that higher circular:linear ANRIL was associated with decreased beta cell proliferation. Our study points to a combined involvement of both linear and circular ANRIL species in T2D phenotypes and opens the door for future studies of the molecular mechanisms by which ANRIL impacts cellular function in pancreatic islets.
Seroconversion to mRNA SARS-CoV-2 vaccines in patients with autoimmune cytopenias and bone marrow failures
Authors: Fattizzo Bruno , Bortolotti Marta , Giannotta Juri Alessandro , Consonni Dario , Cantoni Silvia , Barcellini Wilma 
Published: May 2022

AbstractData concerning the efficacy of SARS-CoV-2 vaccines in patients with non-oncological hematologic conditions are lacking. These include autoimmune cytopenias (autoimmune hemolytic anemia AIHA, immune thrombocytopenia ITP, and autoimmune neutropenia), and bone marrow failure syndromes (aplastic anemia, low risk myelodysplastic syndromes, and paroxysmal nocturnal hemoglobinuria). These conditions may relapse/reactivate after COVID-19 infection and vaccine. Moreover, they are mainly handled with immunosuppressive drugs that may hamper the response to vaccine. In this study, we prospectively evaluated the rate of seroconversion after mRNA SARS-CoV-2 vaccines in patients with autoimmune cytopenias or bone marrow failure syndrome after 2 ± 1 months from the last vaccine dose. Overall, 149 patients were tested and 135 (91%) seroconverted. The highest proportion of non-responders was observed in Evans syndrome (association of ITP and AIHA) and warm AIHA patients (p = 0.001), in those with lower levels of baseline serum IgG (p = 0.008), and in patients on active therapy with steroids (p = 0.03) who also had lower anti-Spike titers. The latter were inversely related with age, and a positively with lymphocyte counts. Additionally, patients who had received rituximab within 12 months from vaccination showed higher rates of non-response (p = 0.03) as compared to those treated before. Contrarily, cyclosporine alone, complement inhibitors, and bone marrow stimulating agents had no detrimental effect on seroconversion. These data suggest maintaining high vigilance and adherence to preventive/protective measures in this population since a proportion of cases may not respond or exhibit low anti-Spike titers.
Additional treatment of vitamin D for improvement of insulin resistance in non-alcoholic fatty liver disease patients: a systematic review and meta-analysis
Authors: Sindhughosa Dwijo Anargha , Wibawa I Dewa Nyoman , Mariadi I Ketut , Somayana Gde 
Published: May 2022

AbstractInsulin resistance provides an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Several studies already evaluate vitamin D supplementation for NAFLD patients in relation to insulin resistance. The results obtained still carry conflicting results. This study aimed to evaluate the effect of additional treatment of vitamin D for the improvement of insulin resistance in NAFLD patients. Relevant literatures were obtained from PubMed, Google Scholar, COCHRANE, and Science Direct database. The obtained studies were analyzed using fixed effect model or random effect model. Seven eligible studies with a total of 735 participants were included. Vitamin D supplementation improves insulin resistance in NAFLD patients, marked by reduced Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), with pooled mean difference − 1.06 (p = 0.0006; 95% CI − 1.66 to − 0.45). Vitamin D supplementation increase the level of vitamin D serum with pooled mean difference of 17.45 (p = 0.0002; 95% CI 8.33 to 26.56). Vitamin D supplementation decrease ALT levels, with pooled mean difference of − 4.44 (p = 0.02; 95% CI − 8.24 to − 0.65). No effect was observed for AST levels. Vitamin D supplementation provides beneficial effects on the improvement of insulin resistance in NAFLD patients. This supplementation may reduce HOMA-IR in such patients. It may serve as a potential adjunctive treatment for NAFLD patients.
Late non-fasting plasma glucose predicts cardiovascular mortality independent of hemoglobin A1c
Authors: Wang Yutang , Fang Yan 
Published: May 2022

AbstractIt is unknown whether non-fasting plasma glucose (PG) is associated with cardiovascular disease (CVD) mortality. This study aimed to investigate this association in US adults. This study included adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. Mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of PG for CVD mortality. Among 34,907 participants, 1956, 5564, and 27,387 had PG from participants in early non-fasting, late non-fasting, and fasting states, respectively (defined as a period since last calorie intake of 0–2.9, 3.0–7.9, or ≥ 8.0 h, respectively). This cohort was followed up for 455,177 person-years (mean follow-up, 13.0 years), with 2,387 CVD deaths being recorded. After adjustment for all confounders including hemoglobin A1c (HbA1c), only late non-fasting PG (continuous, natural log-transformed) was positively associated with CVD mortality risks (hazard ratio, 1.73; 95% confidence interval 1.12–2.67). Higher late non-fasting PG (dichotomous, at a cut-off of 105, 110, or 115 mg/dL) was associated with higher CVD mortality risks. In addition, at the cut-off of 115 mg/dL, higher late non-fasting PG was associated with higher CVD mortality risks in those with either a normal (< 5.7%) or prediabetic HbA1c level (from 5.7 to 6.4%). In conclusion, late non-fasting PG predicts CVD mortality independent of HbA1c. Late non-fasting PG with a cut-off of 115 mg/dL may be used to identify those at high CVD risk.
Fixed‐time non‐singular terminal sliding mode control with globally fast convergence
Authors: Li Huijie , Cai Yuanli 
Published: May 2022

AbstractThis paper investigates a fixed‐time terminal sliding mode (TSM) control scheme of second‐order non‐linear uncertain systems. A globally fast fixed‐time stable system is proposed, and the convergence time is established with the Lyapunov method. Then, a novel non‐singular TSM utilising the proposed fixed‐time stable system and an auxiliary polynomial function is constructed. Meanwhile, a fixed‐time disturbance observer technique is employed to estimate the matched lumped perturbation. Globally fast fixed‐time convergence of the closed‐loop system is guaranteed with the phase plane analysis and Lyapunov tools, and the upper bound of the settling time independent of the initial conditions can be predefined by the controller parameters. Finally, the simulation results of a single inverted pendulum system are included to confirm the validity of the proposed methodology while comparing with some popular TSM control strategies.
Passive radar downrange imaging with multiple transmitters and one receiver
Authors: Brandewie Aaron , Burkholder Robert J. 
Published: May 2022

AbstractPassive radar systems use illuminators of opportunity to illuminate targets instead of dedicated radar transmitters. The signals of opportunity have lower bandwidth than dedicated active radar systems, leading to poor downrange resolution. Multiple signals of opportunity can be coherently combined to increase the overall bandwidth of the system, and therefore create finer resolution images. These signals are usually separated in the frequency domain (non‐contiguous), which causes large unwanted grating lobe artefacts in the image when using back‐projection or Fourier transform based imaging. Additionally, these signals may originate from transmitters not located at the same position. A calibration method is developed to align the downrange responses and coherently combine the two signals. A compressive sensing‐based algorithm is used to combine the calibrated non‐contiguous frequency data, and is shown to mitigate the grating lobe artefacts that occur when using a back‐projection algorithm. This approach is validated with simulated and experimental data from a passive radar system tracking a commercial airline using two digital television (DTV) broadcast transmitters.
Yutu-2 radar observation of the lunar regolith heterogeneity at the Chang’E-4 landing site
Authors: Ding Chunyu , Xiong Siting , Li Jing , Su Yan , Huang Shaopeng 
Published: May 2022

Context.The lunar penetrating radar (LPR) carried by the Yutu-2 rover performed the first in situ measurement of the subsurface structure and physical properties of the subsurface materials on the far side of the Moon. It provides an unprecedented opportunity to study the formation and evolution of the lunar surface.Aims.This paper aims to quantitatively estimate the heterogeneity of the lunar regolith using the high-frequency Yutu-2 radar observation and constrain the modeling parameters (e.g., autocorrelation length) on a radar simulation.Methods.The heterogeneity of the lunar regolith was quantified by comparing the simulation and observation acquired by the high-frequency Yutu-2 radar within the first 17 lunar days after its landing. The radar simulation was determined by the numerical calculation of the stochastic regolith model. The change in the autocorrelation length to the modeling was derived by calculating the coarseness of the model.Results.The disturbance range of the lunar regolith with a thickness of ~12 m at the Chang’E-4 landing site is constrained to be ~0.20 ± 0.06 m, indicating a high self-similarity. The stochastic model’s spatial disturbance is controlled by the autocorrelation length and is also scaled by the model size, and the radar scattering echo strength decreases with the increase in autocorrelation length.Conclusions.We conclude that the heterogeneity of lunar regolith is positively related to the geological age. The application of the disturbance range at the decimeter scale might provide a valuable reference to assist in interpreting the radar observation data of the Moon (e.g., Arecibo radar, Min-SAR and Mini-RF, and in situ LPR).