bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health over the life course: Evidence for a U‐shape?
Authors: Dijk Hermien , Mierau Jochen 
Published: October 2022

AbstractMental health problems impose substantial individual and societal costs over the life‐cycle. The age‐profile of mental health problems is, however, not well understood. Hence, we study the age‐profile of mental health while introducing minimal bias to reach identification. Using mental health data from the United States Panel Study of Income Dynamics we apply first difference estimation to derive an unbiased estimate of the second derivative of the age effect as well as an estimate up to a linear period trend of the first derivative. Next, we use a battery of estimators with varying restrictions to approximate the first derivative. Our results suggest that the age profile of mental health in the US is not U‐shaped and we find tentative evidence that the age‐profile could follow an inverse U‐shape where individuals experience a mental health high during their life course. Further analyses, using German and Dutch data, confirm that these results do not only apply to the US, but also to Germany and the Netherlands.
Exploring the dynamics of flow attenuation at a beaver dam sequence
Authors: Graham Hugh A. , Puttock Alan K. , Elliott Mark , Anderson Karen , Brazier Richard E. 
Published: October 2022

AbstractBeavers influence hydrology by constructing woody dams. Using a Before After Control Impact experimental design, we quantified the effects of a beaver dam sequence on the flow regime of a stream in SW England and consider the mechanisms that underpin flow attenuation in beaver wetlands. Rainfall‐driven hydrological events were extracted between 2009 and 2020, for the impacted (n = 612) and control (n = 634) catchments, capturing events 7 years before and 3 years after beaver occupancy, at the impacted site. General additive models were used to describe average hydrograph geometry across all events. After beaver occupancy, Lag times increased by 55.9% in the impacted site and declined by 17.5% in the control catchment. Flow duration curve analysis showed a larger reduction in frequency of high flows, following beaver dam construction, with declines of Q5 exceedance levels of 33% for the impacted catchment and 15% for the control catchment. Using event total rainfall to predict peak flow, five generalized linear models were fitted to test the hypothesis that beaver dams attenuate flow, to a greater degree, with larger storm magnitude. The best performing model showed, with high confidence, that beaver dams attenuated peak flows, with increasing magnitude, up to between 0.5 and 2.5 m3 s−1 for the 94th percentile of event total rainfall; but attenuation beyond the 97th percentile cannot be confidently detected. Increasing flow attenuation, with event magnitude, is attributed to transient floodplain storage in low gradient/profile floodplain valleys that results from an increase in active area of the floodplain. These findings support the assertion that beaver dams attenuate flows. However, with long‐term datasets of extreme hydrological events lacking, it is challenging to predict the effect of beaver dams during extreme events with high precision. Beaver dams will have spatially variable impacts on hydrological processes, requiring further investigation to quantify responses to dams across differing landscapes and scales.
The importance of proper pH adjustment and control to achieve complete in situ enhanced reductive dechlorination
Authors: Ortiz-Medina Juan Fausto , Yuncu Bilgen , Ross Lydia , Elkins Brad 
Published: October 2022

Abstract
In situ bioremediation of chlorinated compounds such as perchloroethylene (PCE) and trichloroethylene (TCE) through enhanced reductive dechlorination (ERD) requires appropriate growth conditions for organohalide-respiring bacteria (OHRB). One of the most important factors controlling OHRB metabolism is groundwater pH. Dehalococcoides spp. (DHC) growth may be inhibited when pH is lower than 6.0, which can lead to the accumulation of toxic daughter compounds including cis-dichloroethylene (cDCE) and vinyl chloride (VC). Aquifer pH may decline as HCl is released during reductive dechlorination and from substrate fermentation to fatty acids and carbonic acid. In this article, we demonstrate that using proper pH adjustment and control in situ is an appropriate strategy to achieve complete ERD (i.e., complete conversion of PCE and TCE to nontoxic ethylene) in remediation sites with inherently low pH values and/or low buffering capacity. To analyze the effectiveness of this approach, field monitoring results are presented for a challenging site containing high concentrations of PCE and TCE (&gt;10 000 µg/L and &gt;1000 µg/L, respectively) and low aquifer pH (~4.9). Addition of a bioaugmentation culture, emulsified vegetable oil (EVO), and a colloidal buffer (CoBupHTM) to increase pH, stimulated rapid conversion of PCE and TCE to cDCE and VC. However, further conversion of cDCE and VC was very limited. To stimulate complete conversion to ethylene, additional CoBupHTM and nutrients were injected, resulting in a rapid increase in metabolic rates, and maintained the aquifer pH at ~6.5 for more than five years, thus demonstrating that complete ERD can be achieved in sites with similar characteristics. Proper pH adjustment and control is needed to limit the accumulation of toxic intermediates, maintaining in situ bioremediation as an efficient, affordable, and environmentally friendly option to treat chlorinated compounds. Integr Environ Assess Manag 2023;19:943–948. © 2022 SETAC
Classifying environmental significance levels of production-oriented operational activities with F-ARAS and F-MOORA methods
Authors: Polat Ulviye 
Published: October 2022

Abstract
In most decision analysis approaches, application results are obtained in the form of a ranking or selection set. However, classification is needed for analysis of results. In this study, “environmental significance levels and range values” were created for the ranking results obtained using fuzzy Multi Criteria Decision Making approaches. Environmental significance levels have been established for 26 operational activities for which environmental impacts have been determined. Operational activities were analyzed using the Fuzzy-Additive Ratio Assessment (F-ARAS), Fuzzy-Multi Objective Optimization by Ratio Analysis (F-MOORA) Ratio, and F-MOORA Reference Point methods with six evaluation criteria, including the total impact score criteria. The results obtained were analyzed with “environmental significance levels and range values,” which can also be named as environmental risk classes created for the first time in this study depending on the changes in standard deviation. According to the comparison results, when F-ARAS and F-MOORA Ratio methods were evaluated together, 19 activities were in the same class (73%). Integr Environ Assess Manag 2023;19:763–774. © 2022 SETAC
Angiogenic factors assessment in pre‐eclampsia high‐risk population for the prediction of small‐for‐gestational age neonates: A prospective longitudinal study
Authors: Mula Raquel , Prats Pilar , García Sandra , Serra Bernat , Scazzocchio Elena , Meler Eva 
Published: October 2022

AbstractObjectiveThe authors aimed to compare cross‐sectional versus longitudinal models for prediction of small‐for‐gestational age (SGA) neonates among pregnancies with high risk of early pre‐eclampsia (PE).MethodsA prospective longitudinal study was performed in Hospital Universitari Dexeus, Barcelona. The study population included 390 pregnancies with a high risk of early PE according to the first trimester algorithm. Cross‐sectional models combining first trimester risk plus placental growth factor and FMS‐like tyrosine kinase 1/placental growth factor ratio, respectively, were created at 19–22, 24–26, and 27–30 weeks and compared with a model assessing longitudinal changes of these parameters. Models adding mean uterine artery pulsatility index and abdominal circumference were evaluated. SGA neonates were defined as having a birth weight less than the tenth centile.ResultsThe predictive performance of a model assessing longitudinal changes of angiogenic factors was similar to that of single evaluations at the second and early third trimesters. The performance of the models combining angiogenic factors with mean uterine artery pulsatility index and abdominal circumference was better than those using only biochemical markers. However, the longitudinal evaluation of biochemical and biophysical parameters did not perform better than cross‐sectional evaluations.ConclusionsEvaluation of angiogenic factors are useful for prediction of SGA neonates in a high‐risk population for early PE. However, longitudinal models do not increase their predictive capacity.
Obstetric rectal buttonhole tears: A case series and literature review
Authors: Tunney Elizabeth , O'Leary Bobby , Malone Fergal , Geary Michael 
Published: October 2022

AbstractIntroductionIsolated rectal buttonhole tears are a rare obstetric complication and so there is a lack of consensus for their management. The current case series reviews the published literature on obstetric rectal buttonhole injuries and provides further cases from our institution.MethodsA literature review was performed and all results were reviewed. Rectal buttonhole tears following vaginal delivery between 2012 and 2022 in our institution were identified. Repair technique and postoperative management were recorded.ResultsThere were 14 published case reports. Seven case reports described a two‐layer closure, and seven reports described a three‐layer closure. Four cases were repaired in collaboration with colorectal surgeons. Twelve cases were asymptomatic after 6 weeks. One woman had a defunctioning stoma following a wound breakdown and one woman was readmitted with a rectal hemorrhage. We identified two women in our institution with buttonhole tears. Three‐layer repairs were performed in both cases and each woman made an uneventful recovery.ConclusionRepair techniques of rectal buttonhole tears vary among institutions. Despite this variance, most women experience no short‐term morbidity following these injuries. This review adds to the current literature with examples of different repair techniques and outcomes.
Creation of a novel specialty residency in thrombosis and hemostasis management
Authors: Inglis Lauren N. , Triller Darren M. , Burnett Allison E. , Grandoni Jessica , Matta Lina , Sylvester Katelyn , Dager William E. , Gulseth Michael P. , Fanikos John 
Published: October 2022

AbstractAntithrombotic and hemostatic medications are essential, yet high‐risk therapies commonly used for the prevention and treatment of thrombosis and bleeding. Since first demonstrating the ability to improve the safety and quality of heparin and warfarin‐related care many years ago, pharmacists now play an important expanded role in more comprehensive and complex thrombosis and hemostasis management programs. Such programs encompass the prevention and treatment of thrombosis and bleeding across care settings, medical indications, and professional services. These programs impact not only appropriate use of antithrombotic medications, but also of antidotes, blood products, medical devices, laboratory testing, and other important aspects of care. In addition to providing direct patient care, pharmacists are increasingly involved in the development and implementation of system‐level processes and quality improvement activities that require technical knowledge, leadership skills, and effective multidisciplinary collaboration. Evolution in health care regulation and accreditation standards, along with national efforts to advance the concept of Anticoagulation Stewardship, will likely accelerate the growth and expansion of thrombosis and hemostasis management programs, increasing the demand for well‐trained and experienced clinical pharmacists. However, none of the existing accredited specialty pharmacy residency programs encompasses the full range of skills and experiences necessary for new pharmacists to practice effectively in this complex and rapidly evolving field. This manuscript describes the evolution of the Hemostasis and Antithrombotic Stewardship program at Brigham and Women's Hospital and the development of a novel postgraduate year 2 (PGY2) pharmacy residency in this specialty area. It provides details of the new PGY2 residency program curriculum and puts forth a vision of success for such programs at the local and national levels.
Bioactive composite hydrogels as 3D mesenchymal stem cell encapsulation environment for bone tissue engineering: in vitro and in vivo studies
Authors: Vurat Murat Taner , Parmaksiz Mahmut , Elçin Ayşe Eser , Elçin Yaşar Murat 
Published: October 2022

AbstractAlthough decellularized bone matrix (DBM) has often been used in scaffold form for osteogenic applications, its use as a stem cell encapsulation matrix adaptable to surgical shaping procedures has been neglected. This study aimed to investigate the feasibility of utilizing solubilized DBM and nanohydroxyapatite (nHAp)‐incorporated DBM hydrogels as encapsulation matrix for bone marrow‐derived MSCs (BM‐MSCs). First, DBM and DBM/nHAp hydrogels were assessed by physical, chemical, turbidimetric, thermal, and mechanical methods; then, in vitro cytocompatibility and in vitro hemocompatibility were investigated. An in vivo study was performed to evaluate the osteogenic properties of hydrogels alone or with BM‐MSCs encapsulated in them. The findings revealed that hydrogels retained high levels of collagen and glycosaminoglycans after successful decellularization. They were found to be cytocompatible and hemocompatible in vitro, and were able to gel with sufficient mechanical stability at physiological temperature. BM‐MSCs survived in culture for at least 2 weeks as metabolically active when encapsulated in both DBM and DBM/nHAp. Preliminary in vivo study showed that DBM‐nHAp has higher osteogenicity than DBM. Moreover, BM‐MSC encapsulated DMB/nHAp showed predominant bone‐like tissue formation at 30 days in the rat ectopic site compared to its cell‐free form.
The capture of carbonyl sulfide by N‐methyldiethanolamine: A systematic density functional theory investigation
Authors: Xue Jingwen , Liao Rong‐Zhen , Li Jinjin , Cao Yu‐Chen , Zhang Ya‐Qiong 
Published: October 2022

AbstractIn this contribution, the mechanism of carbonyl sulfide (COS) absorption by N‐methyldiethanolamine (MDEA) aqueous solution was explored via theoretical computations. Detailed reaction mechanisms were analyzed using density functional theory (DFT) calculations at the B3LYP‐D3 level of theory. In total, four different pathways for COS absorption by MDEA have been considered. The most favorable pathway for the removal of COS is a three‐step mechanism including the hydrolysis, proton transfer, and dissociation of CO2, and hydrolysis is the rate‐determining step. The mechanisms of the COS absorption by different amines were investigated, and the calculated results suggest that the total energy barrier for the COS absorption by MDEA is comparable to that by monoethanolamine (MEA), diethanolamine (DEA), and diisopropylamine (DIPA), indicating the COS absorption by all the four amines are feasible, while MDEA gives a better performance in terms of thermodynamics.
Atrophic skeletal muscle fibre‐derived small extracellular vesicle miR‐690 inhibits satellite cell differentiation during ageing
Authors: Shao Xiaoyan , Gong Wang , Wang Qianjin , Wang Pu , Shi Tianshu , Mahmut Abdurahman , Qin Jianghui , Yao Yao , Yan Wenjin , Chen Dongyang , Chen Xiang , Jiang Qing , Guo Baosheng 
Published: October 2022

AbstractBackgroundSarcopenia is a common and progressive skeletal muscle disorder characterized by atrophic muscle fibres and contractile dysfunction. Accumulating evidence shows that the number and function of satellite cells (SCs) decline and become impaired during ageing, which may contribute to impaired regenerative capacity. A series of myokines/small extracellular vesicles (sEVs) released from muscle fibres regulate metabolism in muscle and extramuscular tissues in an autocrine/paracrine/endocrine manner during muscle atrophy. It is still unclear whether myokines/sEVs derived from muscle fibres can affect satellite cell function during ageing.MethodsAged mice were used to investigate changes in the myogenic capacity of SCs during ageing‐induced muscle atrophy. The effects of atrophic myotube‐derived sEVs on satellite cell differentiation were investigated by biochemical methods and immunofluorescence staining. Small RNA sequencing was performed to identify differentially expressed sEV microRNAs (miRNAs) between the control myotubes and atrophic myotubes. The target genes of the miRNA were predicted by bioinformatics analysis and verified by luciferase activity assays. The effects of identified miRNA on the myogenic capacity of SCs in vivo were investigated by intramuscular injection of adeno‐associated virus (AAV) to overexpress or silence miRNA in skeletal muscle.ResultsOur study showed that the myogenic capacity of SCs was significantly decreased (50%, n = 6, P < 0.001) in the tibialis anterior muscle of aged mice. We showed that atrophic myotube‐derived sEVs inhibited satellite cell differentiation in vitro (n = 3, P < 0.001) and in vivo (35%, n = 6, P < 0.05). We also found that miR‐690 was the most highly enriched miRNA among all the screened sEV miRNAs in atrophic myotubes [Log2 (Fold Change) = 7, P < 0.001], which was verified in the atrophic muscle of aged mice (threefold, n = 6, P < 0.001) and aged men with mean age of 71 ± 5.27 years (2.8‐fold, n = 10, P < 0.001). MiR‐690 can inhibit myogenic capacity of SCs by targeting myocyte enhancer factor 2, including Mef2a, Mef2c and Mef2d, in vitro (n = 3, P < 0.05) and in vivo (n = 6, P < 0.05). Specific silencing of miR‐690 in the muscle can promote satellite cell differentiation (n = 6, P < 0.001) and alleviate muscle atrophy in aged mice (n = 6, P < 0.001).ConclusionsOur study demonstrated that atrophic muscle fibre‐derived sEV miR‐690 may inhibit satellite cell differentiation by targeting myocyte enhancer factor 2 during ageing.
Recent tPA administration can cause pseudo‐hyperargininemia and may mimic arginase deficiency or arginine supplementation
Authors: Cusmano‐Ozog Kristina P. , Renck Alicia K. , Tise Christina G. 
Published: October 2022

AbstractIndividuals suspected of or diagnosed with a rare disorder, including inherited metabolic disorders (IMD), often need frequent and/or urgent vascular access for blood draws and treatment, making central indwelling catheters commonly used devices in this patient population. These indwelling catheters are prone to thrombosis, limiting vascular access. This complication is frequently resolved with the use of altepase, a recombinant tissue plasminogen activator (tPA). This report describes two individuals, one with a known IMD and one undergoing evaluation for an IMD, who were found to have hyperargininemia (>500 μM; reference 10–140 μM) by plasma amino acid (PAA) analysis of a specimen collected ~1.5–3 h after clearance of an indwelling catheter with tPA. In both cases, hyperargininemia resolved with repeat testing, suggesting pseudo‐hyperargininemia secondary to tPA administration. Quantitative amino acid analysis of the administered tPA demonstrated an arginine level of ~200 mM, supporting tPA as the cause of pseudo‐hyperargininemia. Certain formulations of tPA contain high concentrations of arginine, which if not cleared properly can result in marked elevations of arginine, mimicking arginase deficiency or suggesting arginine supplementation. Thus, the possibility of pseudohyperargininemia due to tPA administration should be considered when obtaining PAAs from an indwelling catheter in any individual being evaluated or managed for an IMD.
ε‐Poly‐l‐lysine conjugated gold nanorod probe to monitor antimicrobial activity and mechanism of action by surface‐enhanced Raman spectroscopy
Authors: Singh Manish Kumar , Singh Anant K. , Dunmore Tyren J. , Singh Jagriti 
Published: October 2022

AbstractAntimicrobial peptides have been demonstrated to display an immediate response to a large set of pathogenic activity against viruses, bacteria, and fungi by virtue of their local binding with phospholipid phosphatidylserines to exert cytotoxic effect. Plasmonic nanostructures are particularly appealing in medical diagnostics and therapeutics owing to their biocompatibility and ease of surface modification. The current article reports a development of ε‐poly‐l‐lysine modified gold nanorod (PLL‐AuNR) Raman‐active system that can be used to target pathogenic bacteria along with rapid monitoring of antimicrobial action from environmental samples. Result indicates a remarkable change in Raman enhancement factor from 1.49 × 104 to 2.17 × 107 after addition of Salmonella, Bacillus subtilis, and Escherichia coli bacteria in PLL‐AuNR colloid, enabling a large optical window to monitor the process of pathogenic action. Antimicrobial assay with PLL‐AuNR reveals significantly high cytotoxic values of ~92% in E. coli, ~90% in B. subtilis, and ~87% in Salmonella compared with their respective responses in bare PLL, which shows ~37% in E. coli, ~32% in B. subtilis, and ~27% in Salmonella, which proportionally collaborates with change in surface‐enhanced Raman spectroscopy (SERS) intensity beyond 10 min of incubation time. Major experimental design parameters and possible mechanism that relates unusual plasmonic enhancement and antimicrobial action of PLL‐AuNR system have also been discussed.
Effect of storage time on chemical compositions, physiological and cooking quality characteristics of different rice types
Authors: Zhu Dawei , Shao Yafang , Fang Changyun , Li Min , Yu Yonghong , Qin Yebo 
Published: October 2022

AbstractBACKGROUNDStorage affects rice quality significantly. The aim of this study was to investigate the changes in the chemical composition and in the physiological and cooking quality characteristics of three rice types after 1 year storage at 25 °C.RESULTSTwo japonica, two indica, and two indica–japonica hybrid rice varieties were selected. After storage, the total starch content decreased. The amylose content of japonica, indica, and indica–japonica hybrid rice increased by 9.63%–11.65%, 2.99%–4.67%, and 8.07%–8.97%, respectively, and the fat content decreased by 60.00%–65.00%, 37.21%–46.51%, and 41.67%–42.42%, respectively. The abscisic acid (ABA) and raffinose content decreased after 1 year's storage; the former decreased gradually during the storage and the latter increased by 19.35%–45.45%, 7.02%–10.77%, and 16.13%–28.13%, respectively, after 4 months’ storage and then decreased to the lowest level after 1 year's storage. The activity of antioxidant enzymes deceased, which resulted in the increases in fatty acid value and malondialdehyde (MDA). The changes in chemical composition after 1 year storage led to the deterioration of rice cooking quality, which was reflected in the decrease in viscosity and increases in gelatinization temperature and cooked rice hardness.CONCLUSIONAfter 1 year's storage, the rice chemical composition changed and physiological and cooking quality characteristics decreased. Compared with japonica and indica–japonica hybrid rice, indica rice was more stable during 1 year storage. This may be due to the higher content of ABA and raffinose in fresh rice. Our findings will provide information for the identification and breeding of storable rice cultivars. © 2022 Society of Chemical Industry.