bluuebunny/crossref_metadata_2025_split huggingface dataset:
Back to school – The teachers’ worries and needs having a childhood cancer patient or survivor in their class
Authors: Otth Maria , Scheinemann Katrin 
Published: November 2022

BackgroundA cancer diagnosis during childhood or adolescence causes nursery and school absences to various degrees. Attending school and meeting classmates gives many children and adolescents some normality back. Nevertheless, it can cause fears and concerns among the teachers. We are currently lacking information about the fears and needs of teachers having a child or adolescent diagnosed with cancer or with a cancer history in their classes. With this study, we aim to close this knowledge gap and assess the teachers’ fears, worries and information needs having a child or adolescent diagnosed with cancer in the class to develop a suitable information tool (flyer).MethodsWe performed an online survey including teachers covering all grades from nursery to vocational school within the catchment area of our hospital. The survey included separate questions for experience with students still receiving active treatment and those in follow-up care. Answer options included tick boxes and open-ended questions, which we grouped thematically. We used descriptive analysis to describe the survey findings, resulting in a newly developed flyer.ResultsIn total 358 teachers participated in the survey, 80% were female, 63% worked in nursery or primary school. One quarter (26%) had experience with a student diagnosed with cancer. Most teachers with (81%) and without (85%) experience reported at least one concern. The top three concerns reported were: (1) how to inform the class, (2) the resilience of the student and (3) how to deal with the student and his or her family. The teachers preferred oral information by physicians or parents and written information equally. Information on resilience, guidelines with an emergency situation, and the need for cancer-specific information were considered important by about 75-94% of the teachers.ConclusionMost teachers reported concerns, which we cover in a newly developed information flyer. However, such a flyer cannot replace individual communication between health care professionals and teachers. The identified concerns are likely to be transferable to other school systems and countries.
Small incision reduction and external fixation for the treatment of delayed over fourteen days supracondylar humeral fractures in children
Authors: Liu Shuai , Peng YingYing , Liu JiaTong , Ou ZiXuan , Wang ZeZheng , Rai Saroj , Lin WeiFeng , Tang Xin 
Published: November 2022

BackgroundSupracondylar humeral fractures (SHF) are the most common type of fracture occurring at the distal humerus in children. In patients with delayed presentation of SHF, closed reduction is challenging to achieve with traditional reduction maneuvers. This study aimed to report the clinical results of pediatric SHF delayed over 14 days treated by closed reduction with a minimally invasive technique and external fixation and evaluate the efficacy of this technique.MethodsBetween October 2010 and September 2018, children with delayed presentation of SHF over 14 days were retrospectively included in this study. The patients received closed reduction with a minimally invasive technique followed by external fixation. The demographics and radiographic data were collected. The Mayo Elbow Performance Score (MEPS) and the Flynn criteria were used to evaluate the clinical outcomes of treatments.ResultsA total of 11 children (aged 4–13 years) with delayed presentation (range, 14–22 days) were recruited. They received surgery using closed reduction with a minimally invasive technique followed by external fixation. None of the surgery was done with the open method. After surgery, the patients' carrying angle returned to normal. The radiological union was evident in 8 to 12 weeks in all fractures without complications. Every patient had a good to excellent score on the MEPS and the Flynn criteria.ConclusionsThe results of this series indicated a satisfactory outcome in children with delayed more than 14 days of supracondylar humeral fractures. The closed reduction with a minimally invasive technique followed by external fixation is an alternative treatment for such injury.
Association of high-sensitivity C-reactive protein and anemia with acute kidney injury in neonates
Authors: Zhang Peiyao , Tong Yuanyuan , Yuan Deshan , Li Yixuan , Jin Yu , Bai Liting , Gao Peng , Wang Wenting , Hu Jinxiao , Duan Xin , Liu Jinping 
Published: November 2022

BackgroundThe association of high-sensitivity C-reactive protein (hsCRP) and anemia with postoperative acute kidney injury (AKI) in neonates with congenital heart disease (CHD) is still unclear. The purpose of this study was to examine whether anemia-associated AKI is modulated by hsCRP in neonates.MethodsThis study included 253 consecutive neonatal patients who underwent CHD surgery in a national tertiary hospital. We investigated the association between postoperative AKI with baseline hsCRP, anemia, and their interaction by multivariable logistic regression analyses.ResultsThe incidence of AKI was 24.1% in the entire cohort. After being adjusted for covariates, hsCRP level was negatively correlated with AKI (P &lt; 0.01 for 1 mg/L threshold), whereas anemia emerged as an independent risk factor of AKI (P = 0.02). In addition, there was a significant interaction between anemia and hsCRP level (P = 0.01). In neonates with hsCRP &lt; 1 mg/L, anemia was positively associated with AKI (P = 0.03). However, no significant association was found between anemia and AKI in the context of hsCRP ≥ 1 mg/L. Combination of anemia and hsCRP &lt; 1 mg/L was independently correlated with the risk of AKI (P &lt; 0.01), while concomitant anemia and hsCRP ≥ 1 mg/L or hsCRP &lt; 1 mg/L combined with non-anemia was not.ConclusionsIn neonates with CHD, the risk of anemia-associated AKI may be modulated by hsCRP level. Attention should be paid to neonates with preoperative anemia and baseline hsCRP &lt; 1 mg/L to reduce the risk of postoperative AKI.
Neonatal resuscitation monitoring: A low-cost video recording setup for quality improvement in the delivery room at the resuscitation table
Authors: Olson Linus , Bui Xuan Anh , Mpamize Allan , Vu Hien , Nankunda Jolly , Truong Tung Thanh , Byamugisha Josaphat , Dempsey Tina , Lubulwa Clare , Winroth Axel , Helldén Daniel ,   NeoSupra & NeoSpirit Teams, Nguyen Anh Duy , Alfvén Tobias , Pejovic Nicolas , Myrnerts Höök Susanna 
Published: November 2022

BackgroundThe quality of neonatal resuscitation after delivery needs to be improved to reach the Sustainable Development Goals 3.2 (reducing neonatal deaths to &lt;12/1,000 live newborns) by the year 2030. Studies have emphasized the importance of correctly performing the basic steps of resuscitation including stimulation, heart rate assessment, ventilation, and thermal control. Recordings with video cameras have previously been shown to be one way to identify performance practices during neonatal resuscitation.MethodsA description of a low-cost delivery room set up for video recording of neonatal resuscitation. The technical setup includes rechargeable high-definition cameras with two-way audio, NeoBeat heart rate monitors, and the NeoTapAS data collection tools for iPad with direct data export of data for statistical analysis. The setup was field tested at Mulago National Referral Hospital, Kampala, Uganda, and Phu San Hanoi Hospital, Hanoi, Vietnam.ResultsThe setup provided highly detailed resuscitation video footage including data on procedures and team performance, heart rate monitoring, and clinical assessment of the neonate. The data were analyzed with the free-of-charge NeoTapAS for iPad, which allowed fast and accurate registration of all resuscitative events. All events were automatically registered and exported to R statistical software for further analysis.ConclusionsVideo analysis of neonatal resuscitation is an emerging quality assurance tool with the potential to improve neonatal resuscitation outcomes. Our methodology and technical setup are well adapted for low- and lower-middle-income countries settings where improving neonatal resuscitation outcomes is crucial. This delivery room video recording setup also included two-way audio communication that potentially could be implemented in day-to-day practice or used with remote teleconsultants.
Necrotic-like BV-2 microglial cell death due to methylmercury exposure
Authors: Martins B. , Novo J. P. , Fonseca É. , Raposo R. , Sardão V. A. , Pereira F. , Oriá R. B. , Fontes-Ribeiro C. , Malva J. 
Published: November 2022

Methylmercury (MeHg) is a dangerous environmental contaminant with strong bioaccumulation in the food chain and neurotoxic properties. In the nervous system, MeHg may cause neurodevelopment impairment and potentially interfere with immune response, compromising proper control of neuroinflammation and aggravating neurodegeneration. Human populations are exposed to environmental contamination with MeHg, especially in areas with strong mining or industrial activity, raising public health concerns. Taking this into consideration, this work aims to clarify pathways leading to acute toxic effects caused by MeHg exposure in microglial cells. BV-2 mouse microglial cells were incubated with MeHg at different concentrations (0.01, 0.1, 1 and 10 µM) for 1 h prior to continuous Lipopolysaccharide (LPS, 0.5 μg/ml) exposure for 6 or 24 h. After cell exposure, reactive oxygen species (ROS), IL-6 and TNF-α cytokines production, inducible nitric oxide synthase (iNOS) expression, nitric oxide (NO) release, metabolic activity, propidium iodide (PI) uptake, caspase-3 and -9 activities and phagocytic activity were assessed. MeHg 10 µM decreased ROS formation, the production and secretion of pro-inflammatory cytokines IL-6, TNF-α, iNOS immunoreactivity, the release of NO in BV-2 cells. Furthermore, MeHg 10 µM decreased the metabolic activity of BV-2 and increased the number of PI-positive cells (necrotic-like cell death) when compared to the respective control group. Besides, MeHg did not interfere with caspase activity or the phagocytic profile of cells. The short-term effects of a high concentration of MeHg on BV-2 microglial cells lead to impaired production of several pro-inflammatory mediators, as well as a higher microglial cell death via necrosis, compromising their neuroinflammatory response. Clarifying the mechanisms underlying MeHg-induced neurotoxicity and neurodegeneration in brain cells is relevant to better understand acute and long-term chronic neuroinflammatory responses following MeHg exposure.
The influence of short sprint performance, acceleration, and deceleration mechanical properties on change of direction ability in soccer players—A cross-sectional study
Authors: Zhang Qingshan , Dellal Alexandre , Chamari Karim , Igonin Pierre-Hugues , Martin Cyril , Hautier Christophe 
Published: November 2022

The study investigated the relationship between short sprint performance and mechanical parameters obtained during the acceleration and deceleration tasks with the change of direction (COD) performance in female and male soccer players. The acceleration and deceleration ability were compared in the “High/Fast” versus “Low/Slow” COD performance group based on a median split analysis in each sex group. One hundred three French soccer players were assessed for the sprinting Force-Velocity (F-V) profile (i.e., theoretical maximal force [F0], velocity [V0], power [Pmax]), 10 m performance, linear deceleration test (maximal braking force [HBFmax], braking power [BPmax], deceleration [Decmax]), and COD performance using 505-test. The 10 m performance was strongly associated with 505-test performance (ES = [0.64 to 0.71]), whereas the sprinting F-V profiles parameters were weakly to moderately correlated with 505- performance (ES = [-0.47 to -0.38]). The BPmax was also moderately associated with 505-test performance (ES: range = [-0.55 to -0.46]). In addition, the High/Fast female COD group presented higher F0, Pmax, HBFmax, and BPmax than the Low/Slow group, whereas the male groups presented very few mechanical differences. Multiple regression analysis shows that the COD performance of male players was determined by 10 m performance and maximum deceleration power. In contrast, no statistically significant model could be found to determine the change of direction performance in female players. In conclusion, the current finding indicated that the only variable strongly associated with COD performance was the linear 10 m sprint time. In the same way, the mechanical parameters obtained from acceleration and deceleration seemed to play a non-neglectable role in this population.
Effectiveness, implementation, and monitoring variables of intermittent hypoxic bicycle training in patients recovered from COVID-19: The AEROBICOVID study
Authors: Costa Gabriel Peinado , Camacho-Cardenosa Alba , Brazo-Sayavera Javier , Viliod Marcela Coffacci De Lima , Camacho-Cardenosa Marta , Foresti Yan Figueiredo , Carvalho Carlos Dellavechia de , Merellano-Navarro Eugenio , Papoti Marcelo , Trapé Átila Alexandre 
Published: November 2022

Hypoxic exposure is safely associated with exercise for many pathological conditions, providing additional effects on health outcomes. COVID-19 is a new disease, so the physiological repercussions caused by exercise in affected patients and the safety of exposure to hypoxia in these conditions are still unknown. Due to the effects of the disease on the respiratory system and following the sequence of AEROBICOVID research work, this study aimed to evaluate the effectiveness, tolerance and acute safety of 24 bicycle training sessions performed under intermittent hypoxic conditions through analysis of peripheral oxyhemoglobin saturation (SpO2), heart rate (HR), rate of perceived exertion (RPE), blood lactate concentration ([La−]) and symptoms of acute mountain sickness in patients recovered from COVID-19. Participants were allocated to three training groups: the normoxia group (GN) remained in normoxia (inspired fraction of O2(FiO2) of ∼20.9%, a city with 526 m altitude) for the entire session; the recovery hypoxia group (GHR) was exposed to hypoxia (FiO2∼13.5%, corresponding to 3,000 m altitude) all the time except during the effort; the hypoxia group (GH) trained in hypoxia (FiO2∼13.5%) throughout the session. The altitude simulation effectively reduced SpO2mean with significant differences between groups GN, GHR, and GH, being 96.9(1.6), 95.1(3.1), and 87.7(6.5), respectively. Additionally, the proposed exercise and hypoxic stimulus was well-tolerated, since 93% of participants showed no or moderate acute mountain sickness symptoms; maintained nearly 80% of sets at target heart rate; and most frequently reporting session intensity as an RPE of “3” (moderate). The internal load calculation, analyzed through training impulse (TRIMP), calculated using HR [TRIMPHR= HR * training volume (min)] and RPE [TRIMPRPE= RPE * training volume (min)], showed no significant difference between groups. The current strategy effectively promoted the altitude simulation and monitoring variables, being well-tolerated and safely acute exposure, as the low Lake Louise scores and the stable HR, SpO2, and RPE values showed during the sessions.
The association between cigarette smoking and health care service utilization among middle-aged and elderly adults in China
Authors: Song Jiarui , Jin Chenggang , Cheng Xi 
Published: November 2022

ObjectiveTo assess the associations between tobacco use and health care service utilization in Chinese individuals aged more or equal to 40 years old.MethodThis research was a cross-sectional study using data from eight provinces in China, and the final sample consisted of 4,733 observations (4,749 participants) aged more or equal to 40 years old. The dependent variable was health care utilization measured by outpatient and inpatient service utilization. Descriptive statistics were used to summarize the socio-demographic characteristics of the sample according to smoking status. The association between tobacco use and health care service utilization was examined by an instrumental variable (IV) probit model.ResultsOf the respondents interviewed in 2020, 3,116 (65.84%) were never smokers, 654 (13.82%) were smokers with the smoking index (SI) &lt;400, and 963(20.34%) were smokers with SI≥400. Smokers with SI &lt;400 reported a 6.80% higher probability of using outpatient services. Smokers with SI &lt;400 and SI≥400 reported a 3.10 and 4.20% higher average probability of using ≥3 outpatient visits than never smokers, respectively. Additionally, smokers with SI &lt;400 and SI≥400 reported a 6.30 and 6.20% higher average probability of using inpatient services than those who had not smoked. Moreover, smokers with SI≥400 were more likely to have had ≥2 hospital visits than nonsmokers.ConclusionsSmokers make greater use of health care services. Control of smoking may ease the burden of related health care utilization.
A study on the impact and buffer path of the internet use gap on population health: Latent category analysis and mediating effect analysis
Authors: He Yuanyuan , Zhou Lulin , Xu Xinglong , Li JunShan , Li Jiaxing 
Published: November 2022

BackgroundThe development of Internet information technology will generate an Internet use gap, which will have certain adverse effects on health, but internet information dependence can alleviate these negative effects.ObjectiveThis article is to demonstrate the negative impact of the internet use gap on population health in developing countries and to propose improvement paths.MethodsThis article used the 2018 China Family Tracking Survey database (N = 11086). The research first used Latent class analysis (LCA) to identify potential categories of users with different Internet usage situations, then used the Bolck, Croon, and Hagenaars (BCH) method to perform latent class modeling with a continuous distal outcome, and finally built an intermediary model about Internet information dependence based on the model constraint function in Mplus software.Results(1) The Internet users can be divided into light-life users (C1: N = 1,061, 9.57%), all-around users (N = 1,980, 17.86%(C2: N = 1,980, 17.86%), functional users (C3: N = 1,239, 11.18%), and pure-life users (C4: N = 6,806, 61.39%). (2) We examined individual characteristics, social characteristics and different living habits, and health differences between the latent classes. For example, there are certain structural differences on the effect of different categories of Internet use on health (C1: M = 3.089, SE = 0.040; C2: M = 3.151, SE = 0.037; C3: M = 3.070, SE = 0.035; C4: M = 2.948, SE = 0.016; P &lt; 0.001). (3) The Internet use gap can affect health through the indirect path of Internet information dependence, and some of the mediation effects are significant. When the functional user group (C3) was taken as the reference group, the mediating effect values of light-life users (C1) and all-around users (C4) on health were −0.050 (SE = 0.18, Est./SE = −3.264, P = 0.001) and −0.080 (SE = 0.010, Est./SE = −8.412, P = 0.000) through Internet information dependence, respectively. However, the effect of categories on health was not significant after adding indirect paths.ConclusionThe Internet use gap has a significant effect on health, and Internet information dependence plays an intermediary role in this effect path. The study proposes that attention should be paid to the diversified development of Internet use, the positive guiding function of Internet information channels should be made good use of, and the countermeasures and suggestions of marginalized groups in the digital age should also be paid attention to and protected.
Birth weight was associated with maternal exposure to intimate partner violence during pregnancy in southern Ethiopia: A prospective cohort study
Authors: Belay Sewhareg , Astatkie Ayalew , Hinderaker Sven Gudmund 
Published: November 2022

IntroductionBirth weight is defined as the first weight of the newborn, ideally measured soon after birth. A recent Ethiopian survey estimated that 48% of births took place in health facilities. Data for women exposed to intimate partner violence (IPV) may be lacking in official statistics because these women may prefer to deliver at home, where data from non-institutional births, including reporting of birth weights, are not routinely recorded.ObjectiveThe aim of this study was to investigate the association between maternal exposure to IPV during pregnancy and birth weight in a community in the Wondo Genet district of southern Ethiopia.MethodsWe carried out a community-based prospective cohort study from February to December 2017. We followed up with 505 pregnant women and their newborns until after delivery. An interview about partner violence was done during pregnancy at home when enrolled. Field assistants who visited the homes measured the birth weight of each baby in grams. Twins and late birth weight measurements were excluded. Factors associated with birth weight were assessed by multiple linear regression.ResultsBirth weight was assessed within 48 h for 477 (94.5%) newborns and between 48 and 72 h for an additional 28 (5.5%). There were 365 (72.3%) institutional deliveries. In an adjusted regression analysis (IPV adjusted for socio-economic status), birth weight was 203 g lower (B −203 95% CI −320 to −87) among newborns of women exposed to IPV than among the unexposed. Birth weight was also lower in girls than in boys, in newborns delivered at home rather than in a health facility, and in babies with a younger gestational age.ConclusionMaternal exposure to IPV during pregnancy was associated with lower baby birth weights. Antenatal clinics should consider routinely identifying IPV-exposed women, and identifying babies with lower birth weights at home is an important indicator.
A network analysis of anxiety and depression symptoms among Chinese nurses in the late stage of the COVID-19 pandemic
Authors: Peng Pu , Chen Qiongni , Liang Mining , Liu Yueheng , Chen Shubao , Wang Yunfei , Yang Qian , Wang Xin , Li Manyun , Wang Yingying , Hao Yuzhu , He Li , Wang Qianjin , Zhang Junhong , Ma Yuejiao , He Haoyu , Zhou Yanan , Li Zejun , Xu Huixue , Long Jiang , Qi Chang , Tang Yi-Yuan , Liao Yanhui , Tang Jinsong , Wu Qiuxia , Liu Tieqiao 
Published: November 2022

BackgroundNurses are at high risk for depression and anxiety symptoms after the outbreak of the COVID-19 pandemic. We aimed to assess the network structure of anxiety and depression symptoms among Chinese nurses in the late stage of this pandemic.MethodA total of 6,183 nurses were recruited across China from Oct 2020 to Apr 2021 through snowball sampling. We used Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder scale-7 (GAD-7) to assess depression and anxiety, respectively. We used the Ising model to estimate the network. The index “expected influence” and “bridge expected influence” were applied to determine the central symptoms and bridge symptoms of the anxiety-depression network. We tested the stability and accuracy of the network via the case-dropping procedure and non-parametric bootstrapping procedure.ResultThe network had excellent stability and accuracy. Central symptoms included “restlessness”, “trouble relaxing”, “sad mood”, and “uncontrollable worry”. “Restlessness”, “nervous”, and “suicidal thoughts” served as bridge symptoms.ConclusionRestlessness emerged as the strongest central and bridge symptom in the anxiety-depression network of nurses. Intervention on depression and anxiety symptoms in nurses should prioritize this symptom.