bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimally invasive bilateral decompressive lumbar laminectomy with unilateral approach: patient series
Authors: Finneran Megan M. , Naik Anant , Hawkins John C. , Nardone Emilio M. 
Published: February 2022

BACKGROUND
Minimally invasive bilateral decompressive lumbar laminectomy with a unilateral approach is a less destructive procedure compared to the traditional open bilateral laminectomy. The objective of this study is to report the authors’ experience with this technique. The first 26 cases performed using the unilateral approach for bilateral decompression are described. Baseline characteristics, operative time, blood loss, and intraoperative complications were collected retrospectively. No specific surgical equipment is needed for this technique.

OBSERVATIONS
Twenty-six patients and a total of 40 lumbar levels were treated. Mean operative time was 82 minutes per level and mean estimated blood loss was 40.4 mL per level. Mean length of hospitalization was 1.65 days. Cerebrospinal fluid leak occurred in 1 of 26 (3.85%) cases.

LESSONS
Although improved stabilization needs to be proven in future long-term studies to clearly show a decrease in need for fusion, the initial experience with a unilateral approach is positive and continued use in minimally invasive spine surgery seems promising.
Simultaneous intracerebral and subarachnoid hemorrhages caused by multiple infectious intracranial aneurysms treated endovascularly and by microsurgical clipping: illustrative case
Authors: Akimoto Ken , Yanaka Kiyoyuki , Nakamura Kazuhiro , Takeda Hayato , Saura Minami , Takada Maya , Hosoo Hisayuki , Matsumaru Yuji , Ishikawa Eiichi 
Published: February 2022

BACKGROUND
Infected intracranial aneurysms are relatively rare but tend to occur in multiple locations. Establishing an optimal treatment strategy for multiple ruptured aneurysms is often challenging, especially when simultaneous ruptures occur in different locations. We report a case of simultaneous intracerebral and subarachnoid hemorrhages caused by the rupture of multiple infected intracranial aneurysms.

OBSERVATIONS
A 23-year-old male with a 2-week history of chronic fever presented with sudden onset of severe headache and visual disturbance. Computed tomography showed intracerebral hemorrhage in the right occipital lobe and subarachnoid hemorrhage in the area of the left Sylvian fissure. Further investigation documented Staphylococcus bacteremia, verrucae on the mitral valve, and aneurysms arising from the right posterior cerebral artery (PCA) and the left middle cerebral artery (MCA). A larger aneurysm arising from the PCA was successfully occluded endovascularly, but subsequent endovascular occlusion of the MCA aneurysm was unsuccessful because some important branches were observed extending from the aneurysm. The left MCA aneurysm was then obliterated by angioplastic clipping via left pterional craniotomy. The patient showed a favorable neurological recovery after treatment.

LESSONS
In such complex cases of infectious aneurysms, the method and timing of treatment need to be carefully determined based on the medical condition.
SOBRE A EDUCAÇÃO LITERÁRIA EM PORTUGAL: GESTÕES E (IM)POSSIBILIDADES
Authors: Dalte Pedro 
Published: February 2022

No presente artigo pretende-se refletir sobre o panorama atual da Educação Literária nos primeiros ciclos de ensino em Portugal e, também, problematizar o papel do professor naquilo que é atinente à promoção da leitura, à seleção do corpus literário e às estratégias e aos objetivos da leitura.
Duración de la lactancia materna, alimentación combinada y riesgo para la salud en jóvenes costarricenses
Authors: Nuñez-Rivas HP , Holst-Schumacher I , Roselló-Araya M , Campos-Saborío N , Guzmán-Padilla S 
Published: February 2022

Objetivo: examinar la asociación entre la duración de la lactancia materna y la alimentación mixta con la obesidad, riesgo cardiometabólico, grasa corporal, conductas de riesgo dietéticas y de actividad física en niños y adolescentes. Sujetos y Método: estudio transversal en 1467 estudiantes de Costa Rica. Se aplicó una entrevista a padres e hijos para recopilar información socioeconómica, escolaridad, conductas de riesgo de la alimentación y actividad física de los jóvenes, duración de la lactancia materna y alimentación mixta. Se evaluó el índice de masa corporal, la circunferencia abdominal y la grasa corporal mediante análisis de bioimpedancia. El riesgo cardiometabólico se midió con el indicador cintura/talla (WHtR ≥ 0,5). Las mediciones fueron realizadas por personal estandarizado. Se aplicó estadística descriptiva y regresión logística. Resultados: la edad de los sujetos fue 11,4 ± 2,6 años; 50,9% hombres; 55,5% clase media; 60% sedentarios y 16% obesos. El 20% fue amamantado sin introducción de fórmula hasta los 6 meses y 13% nunca fue amamantado; más del 60% fue amamantado por ≥ 6 meses. El porcentaje de obesidad de los que recibieron leche materna, sola o en combinación con fórmula, durante ≥ 6 meses fue menor que los que fueron alimentados solo con fórmula (60,8 vs 39,2; p < 0,005). Los niños con riesgo cardiometabólico, dieta no saludable, sedentarismo y que fueron alimentados sólo con fórmula, presentaron mayor riesgo de ser obesos (OR = 18,8, IC 95% 13,2-26,0). Conclusiones: estos resultados son consistentes con otros estudios y refuerzan la protección evidente que tiene la lactancia materna frente al desarrollo de la obesidad.
Reserva ovárica y falla ovárica prematura en niñas y adolescentes postrasplante de progenitores hematopoyéticos
Authors: Paris Claudia , Zepeda Ana , Muñoz Mónica , Camus Adela , Catalán Paula , Sotomayor Cristian , Luengo Rosario , Schulin-Zeuthem Carolina , Brieba Mariela , Romero Fuentes Patricia 
Published: February 2022

El aumento de la sobrevida de niñas y adolescentes después de un trasplante de progenitores hemato- poyéticos (TPH) ha permitido conocer los efectos tardíos de esta terapia. Objetivo: medir la reserva y la falla ováricas prematura después de un TPH.Pacientes y Método: estudio descriptivo, transversal de niñas y adolescentes trasplantadas entre 1999-2011. Se realizó examen ginecológico, exámenes hormonales y ecotomografía ginecológica transabdominal, y se consignó desarrollo puberal pre TPH. Se registraron los siguientes datos de la ficha clínica: patología de base, tipo de acondicionamiento, uso de radioterapia en el acondicionamiento, edad al momento del TPH y haber tenido o tener enfermedad del injerto contra el huésped (EICH) aguda o crónica. Los exámenes hormonales incluyeron hormona folículo estimulante (FSH), hormona luteinizante (LH), estradiol, prolactina (PRL), hormona tiroestimulante (TSH), tiroxina libre, testosterona total, proteína transportadora de hormonas sexuales (SHBG) y hormona antimulleriana (AMH). Análisis estadístico: chi cuadrado y exacto de Fisher con P < 0,05. Resultados fueron expresados como mediana (rango). Resultados: Se evaluaron 41 pacientes, edad al momento del TPH de 6,8 años (1,5-14,1) y 14,8 años (rango: 4-25,4) al momen- to de la evaluación. El 93% de las pacientes trasplantadas tenían patologías oncológicas y recibieron regímenes de acondicionamiento mieloablativos. Todas mostraron una reserva ovárica disminuida. El 72% de las pacientes presentaron una falla ovárica prematura (FOP). Conclusiones: Todas las pacientes estudiadas tenían una reserva ovárica disminuida y la mayoría de ellas una alta prevalencia de FOP. Es indispensable una evaluación ginecológica antes del TPH y un seguimiento posterior para monitorización hormonal e inicio del reemplazo hormonal.
EL PATRIMONIO ARTESANAL: LOS SOMBREROS DE PAJA TOQUILLA
Authors: Aguilar-García María Leonor 
Published: February 2022

En este artículo se aborda el tema del patrimonio cultural y artesanal, distinguiéndolo entre el material e inmaterial; además se destaca la importancia que tiene la conservación del mismo como parte de nuestra cultura e identidad, que es cabalmente lo que singulariza e individualiza a las culturas en el actual mundo globalizado. Dentro del patrimonio artesanal se aborda el tejido de sombreros de paja toquilla, artesanía que fuera declarada como Patrimonio Inmaterial por parte de la UNESCO en diciembre de 2012, y que es considerada como la artesanía másimportante del Ecuador y la más representativa de las provincia de Manabí, Azuay y Cañar.
Palabras clave: Patrimonio cultural y artesanal, patrimonio inmaterial, sombrero de paja toquilla, tejido.
AbstractIn this article the issue of cultural and craft heritage is addressed, distinguishing between material and immaterial; also the importance of its conservation as part of our culture and identity,which is fully what distinguishes and individualizes cultures in today’s globalized world stands. Inside the craft heritage weaving straw hats, crafts was declared Intangible Heritage by UNESCO in December 2012, and is considered the most important craft of Ecuador also the most representative handicrafts of the Provinces of Manabi, Azuay and Canar.Keywords: cultural and craft heritage, intangible heritage, toquilla straw hats, fabric.
Pembuatan Virgin Coconut Oil (VCO) Dengan Metode Enzimatis Dan Fermentasi
Authors: Dwi Sutanto Teja Dwi , Ratnawati Devi , HP Agus Martono 
Published: February 2022

Virgin coconut oil (VCO) is coconut oil that contains medium chain fatty acids (MCFA) which are easily broken down by the body in very high amounts. Besides that, VCO also has very high antioxidant content such as tocopherol and beta-carotene. This PPM activity aims to provide VCO Making Training with the Enzymatic Method with pineapple fruit extract and fermentation with baker's yeast in the community of RT 12 RW 03 Pematang Governor Village, Muara Bangkahulu District, Bengkulu City. The activity began with a lecture followed by a discussion and practice of making VCO with enzymatic and fermentation methods. The results of observations in the field indicate that the target community of this PPM activity is very enthusiastic to take part in this activity because they feel they have gained additional new knowledge about how to make VCO which can complement their knowledge of the known VCO making technique, namely the fishing method. With the knowledge of making VCO taught in this activity, the target community will be able to have alternative methods for making VCO other than what has been known so far with easily obtained equipment. Keywords: VCO; MCFA; antivirus; enzymatic; Fermentation
Removal of Environmental Nanoparticles Increases Protein Synthesis and Energy Production in Healthy Humans
Authors: Antuña Eduardo , Carlos Bermejo-Millo Juan , Caso-Onzain Enrique , Caso-Peláez Enrique , Potes Yaiza , Coto-Montes Ana 
Published: February 2022

Currently, industrial activity causes the environmental release of nanoparticles that have multiple adverse effects on population health. There is a clear correlation between the increase in particulate air pollution and the increases in mortality and morbidity rates in both adults and children, which demonstrates the toxic effects of these particles. However, the effect of particle removal on healthy individuals is unknown. Thus, in this preliminary study, we showed, for the first time, how the filtering equipment that we used significantly reduced a large amount of nanoparticles in a minimum time and induced a reduction of oxidative damage in healthy individuals of both sexes after 25, 50 and 100 days of exposure. These effects led to increased protein synthesis and enhanced mitochondrial efficiency, thus resulting in a highly significant triggering of ATP synthesis. These results not only provide insight into the chronic effects that environmental nanoparticles have on individuals prior to the development of pathologies but also demonstrate a system capable of reversing nanoparticle toxicity and allowing cellular energy recovery.
Endoplasmic Reticulum Stress Is Involved in Muscular Pathogenesis in Idiopathic Inflammatory Myopathies
Authors: Ma Xue , Gao Hua-Jie , Zhang Qing , Yang Meng-Ge , Bi Zhua-Jin , Ji Su-Qiong , Li Yue , Xu Li , Bu Bi-Tao 
Published: February 2022

Objectives: Endoplasmic reticulum (ER) stress plays pivotal roles in the regulation of skeletal muscle damage and dysfunction in multiple disease conditions. We postulate the activation of ER stress in idiopathic inflammatory myopathies (IIM).Methods: Thirty-seven patients with immune-mediated necrotizing myopathy (IMNM), 21 patients with dermatomyositis (DM), 6 patients with anti-synthetase syndrome (ASS), and 10 controls were enrolled. The expression of ER stress-induced autophagy pathway was detected using histological sections, Western blot, and real-time quantitative Polymerase Chain Reaction.Results: ER stress-induced autophagy pathway was activated in biopsied muscle of patients with IMNM, DM, and ASS. The ER chaperone protein, glucose-regulated protein 78 (GRP78)/BiP expression in skeletal muscle correlated with autophagy, myofiber atrophy, myonecrosis, myoregeneration, and disease activity in IMNM.Conclusion: ER stress was involved in patients with IIM and correlates with disease activity in IMNM. ER stress response may be responsible for skeletal muscle damage and repair in IIM.
Machine Learning Algorithms Identify Clinical Subtypes and Cancer in Anti-TIF1γ+ Myositis: A Longitudinal Study of 87 Patients
Authors: Zhao Lijuan , Xie Shuoshan , Zhou Bin , Shen Chuyu , Li Liya , Pi Weiwei , Gong Zhen , Zhao Jing , Peng Qi , Zhou Junyu , Peng Jiaqi , Zhou Yan , Zou Lingxiao , Song Liang , Zhu Honglin , Luo Hui 
Published: February 2022

BackgroundAnti-TIF1γ antibodies are a class of myositis-specific antibodies (MSAs) and are closely associated with adult cancer-associated myositis (CAM). The heterogeneity in anti-TIF1γ+ myositis is poorly explored, and whether anti-TIF1γ+ patients will develop cancer or not is unknown at their first diagnosis. Here, we aimed to explore the subtypes of anti-TIF1γ+ myositis and construct machine learning classifiers to predict cancer in anti-TIF1γ+ patients based on clinical features.MethodsA cohort of 87 anti-TIF1γ+ patients were enrolled and followed up in Xiangya Hospital from June 2017 to June 2021. Sankey diagrams indicating temporal relationships between anti-TIF1γ+ myositis and cancer were plotted. Elastic net and random forest were used to select and rank the most important variables. Multidimensional scaling (MDS) plot and hierarchical cluster analysis were performed to identify subtypes of anti-TIF1γ+ myositis. The clinical characteristics were compared among subtypes of anti-TIF1γ+ patients. Machine learning classifiers were constructed to predict cancer in anti-TIF1γ+ myositis, the accuracy of which was evaluated by receiver operating characteristic (ROC) curves.ResultsForty-seven (54.0%) anti-TIF1γ+ patients had cancer, 78.7% of which were diagnosed within 0.5 years of the myositis diagnosis. Fourteen variables contributing most to distinguishing cancer and non-cancer were selected and used for the calculation of the similarities (proximities) of samples and the construction of machine learning classifiers. The top 10 were disease duration, percentage of lymphocytes (L%), percentage of neutrophils (N%), neutrophil-to-lymphocyte ratio (NLR), sex, C-reactive protein (CRP), shawl sign, arthritis/arthralgia, V-neck sign, and anti-PM-Scl75 antibodies. Anti-TIF1γ+ myositis patients can be clearly separated into three clinical subtypes, which correspond to patients with low, intermediate, and high cancer risk, respectively. Machine learning classifiers [random forest, support vector machines (SVM), extreme gradient boosting (XGBoost), elastic net, and decision tree] had good predictions for cancer in anti-TIF1γ+ myositis patients. In particular, the prediction accuracy of random forest was &gt;90%, and decision tree highlighted disease duration, NLR, and CRP as critical clinical parameters for recognizing cancer patients.ConclusionAnti-TIF1γ+ myositis can be separated into three distinct subtypes with low, intermediate, and high risk of cancer. Machine learning classifiers constructed with clinical characteristics have favorable performance in predicting cancer in anti-TIF1γ+ myositis, which can help physicians in choosing appropriate cancer screening programs.
COVID-19 Recovery Patterns Across Alpha (B.1.1.7) and Delta (B.1.617.2) Variants of SARS-CoV-2
Authors: Kumar Nitya , Quadri Suha , AlAwadhi Abdulla Ismaeel , AlQahtani Manaf 
Published: February 2022

BackgroundB.1.1.7 (alpha) and B.1.617.2 (delta) variants of concern for SARS-CoV-2 have been reported to have differential infectivity and pathogenicity. Difference in recovery patterns across these variants and the interaction with vaccination status has not been reported in population-based studies.ObjectiveThe objective of this research was to study the length of stay and temporal trends in RT-PCR cycle times (Ct) across alpha and delta variants of SARS-CoV-2 between vaccinated and unvaccinated individuals.MethodsParticipants consisted of patients admitted to national COVID-19 treatment facilities if they had a positive RT-PCR test for SARS-CoV-2, and analysis of variants was performed (using whole genome sequencing). Information on vaccination status, age, sex, cycle times (Ct) for four consecutive RT-PCR tests conducted during hospital stay, and total length of hospital stay for each participant were ascertained from electronic medical records.ResultsPatients infected with the delta variant were younger (mean age = 35years vs 39 years for alpha, p&lt;0.001) and had lesser vaccination coverage (54% vs 72% for alpha, p&lt;0.001). RT-PCR Ct values were similar for both variants at the baseline test; however by the fourth test, delta variant patients had significantly lower Ct values (27 vs 29, p=0.05). Length of hospital stay was higher in delta variant patients in vaccinated (3 days vs 2.9 days for alpha variant) as well as in unvaccinated patients (5.2 days vs 4.4 days for alpha variant, p&lt;0.001). Hazards of hospital discharge after adjusting for vaccination status, age, and sex was higher for alpha variant infections (HR=1.2, 95% CI: 1.01–1.41, p=0.029).ConclusionPatients infected with the delta variant of SARS-CoV-2 were found to have a slower recovery as indicated by longer length of stay and higher shedding of the virus compared to alpha variant infections, and this trend was consistent in both vaccinated and unvaccinated patients.
Combined Effect of Microneedling and Platelet-Rich Plasma for the Treatment of Acne Scars: A Meta-Analysis
Authors: Kang Cheng , Lu Dakai 
Published: February 2022

BackgroundMicroneedling is a promising method for the treatment of acne scars, while the effect of microneedling combined with platelet-rich plasma (PRP) remains unknown. We performed a meta-analysis of controlled studies to compare the efficacy and safety of microneedling treatment with and without additional PRP in patients with acne scars.MethodsRandomized and non-randomized controlled studies were identified by search of Medline, Embase, and Cochrane's Library databases. Results were pooled with a random-effects model, incorporating the possible heterogeneity.ResultsFour randomized and 10 split-face non-randomized controlled studies with 472 patients were included. Compared to microneedling therapy without PRP, combined treatment with microneedling and PRP was associated with increased odds of clinical improvement of &gt;50% in Goodman's qualitative scale [GQS: odds ratio (OR): 2.97, 95% confidence interval (CI): 1.96–4.51,p&lt; 0.001;I2= 0%], and a significantly improved mean GQS score (mean difference: −0.32, 95% CI: −0.44 to −0.20,p&lt; 0.001;I2= 0%). Combined treatment was associated with a higher patient satisfying rate (OR: 4.15, 95% CI: 2.13 to 8.09,p&lt; 0.001;I2= 53%), while the incidence of severe adverse events such as severe erythema (OR: 1.59, 95% CI:.73 to 3.46,P= 0.24;I2= 0%) and severe edema (OR: 1.14, 95% CI: 0.47 to 2.76,P= 0.77;I2= 0%) were not significantly different.ConclusionsCombined treatment with microneedling with PRP is more effective than microneedling without PRP for patients with acne scars.
The Positive Effects of Cancer Survivor Support Service on Distress in South Korea: A Nationwide Prospective Study
Authors: Lee Hyun Jeong , Kim Young Ae , Ryu Seong Yeob , Chun Mison , Yim Chang-Yeol , Kang Hee-Taik , Kang Jung Hun , Huh Jung-Sik , Kim Jong-Heun , Lim Kyu-Hyoung , Jung So-Youn , Kwon Hyoung-Cheol , Goh Eurah , Lee Yeon-Seung , Ju Hee Young , Yun E. Hwa , Chang Yoon Jung 
Published: February 2022

Background and AimCancer survivors are gradually increasing, however, they suffer from various difficulties. We aimed to investigate the characteristics of cancer survivors and the effects of the services of the Korean Cancer Survivorship Center Pilot Project launched by the South Korean government on distress.MethodsA prospective observational cohort study was performed on cancer survivors who completed primary treatment. Cancer survivors' distress and symptoms such as fatigue, pain, depressive mood, anxiety, and insomnia were evaluated by well-trained nurses. Regarding their needs, medical and psychosocial support services were provided.ResultsThis study included 1,921 cancer survivors, with a mean age of 57.3 years (68.7% females). Breast cancer was most common, followed by stomach and colorectal cancer. Psychosocial and medical support decreased the percentage of the high-distress group from 50.9 to 30.5% and decreased the percentage of cancer survivors with high scores in fatigue, pain, anxiety, depressive mood, and insomnia. The independent predictors of a low distress level after the use of the services were older age, the relief of fatigue, pain, and insomnia.ConclusionThis study showed that psychosocial and medical support is associated with the lower distress and physical and mental symptoms of cancer survivors. Psychosocial and medical support could contribute to distress relief in cancer survivors. Further management strategies for fatigue, pain and insomnia are required.