bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes based on histopathologic response to preoperative chemotherapy in children with bilateral Wilms tumor: A prospective study (COG AREN0534)
Authors: Chintagumpala Murali M. , Perlman Elizabeth J. , Tornwall Brett , Chi Yueh‐Yun , Kim Yeonil , Hoffer Fredric A. , Kalapurakal John A. , Warwick Anne B. , Shamberger Robert C. , Khanna Geetika , Hamilton Thomas E. , Gow Kenneth W. , Paulino Arnold C. , Gratias Eric J. , Mullen Elizabeth A. , Geller James I. , Fernandez Conrad V. , Ritchey Michael L. , Grundy Paul E. , Dome Jeffrey S. , Ehrlich Peter F. 
Published: April 2022

BackgroundAn objective of the Children's Oncology Group AREN0534 Study was to improve the survival of patients with bilateral Wilms tumors (BWT) by using preoperative chemotherapy of limited duration and tailoring postoperative therapy based on histopathologic response. The authors report outcomes based on postoperative histopathologic responses.MethodsPatients with BWT received treatment with vincristine, dactinomycin, and doxorubicin for 6 or 12 weeks followed by surgery. Postoperative therapy was prescribed based on the highest risk tumor according to the International Society of Pediatric Oncology classification and the Children's Oncology Group staging system.ResultsAnalyses were performed on data from 180 evaluable children. The 4‐year event‐free survival (EFS) and overall survival (OS) rates were 81% (95% CI, 74%‐87%) and 95% (95% CI, 91%‐99%), respectively. Seven patients who had completely necrotic tumors had a 4‐year EFS rate of 100%. Of 118 patients who had tumors with intermediate‐risk histopathology, the 4‐year EFS and OS rates were 82% (95% CI, 74%‐90%) and 97% (95% CI, 94%‐100%), respectively. Fourteen patients who had blastemal‐type tumors had 4‐year EFS and OS rates of 79% (95% CI, 56%‐100%) and 93% (95% CI, 79%‐100%), respectively. Eighteen patients who had diffuse anaplasia had 4‐year EFS and OS rates of 61% (95% CI, 35%‐88%) and 72% (95% CI, 47%‐97%), respectively; and the 4‐year EFS and OS rates of 7 patients who had focal anaplasia were 71% (95% CI, 38%‐100%) and 100%, respectively. There was no difference in the outcomes of patients who had different histopathologic subtypes within the intermediate‐risk group (P = .54).ConclusionsA risk‐adapted treatment approach for BWT results in excellent outcomes. This approach was not successful in improving the outcome of patients who had diffuse anaplasia.
Compressive strength prediction of structural lightweight concrete by applying the recurrent neural network‐fractional order bat optimization algorithm
Authors: Khajehzadeh Mohammad 
Published: April 2022

AbstractNeural networks methods produce an analysis in various fields. The Neural Network is frequently employed for developing statistical methods for nonlinear systems since, the Neural Networks use the simulation benefits of complicated behavior in several problems. In this study, the Recurrent Neural Network and Recurrent Neural Network based on Fractional Order Bat Optimization Algorithm is utilized for predicting the compressive strength of Lightweight Concrete mixes in 3, 7, 14, and 28 days curing. Recurrent Neural Network has been used for having a comparison. The inputs to the network for the compressive strength are made of eight variables: sand, lightweight fine aggregate, water to cement ratio, silica fume utilized in solution, Lightweight course aggregate, silica fume utilized supplementary to cement, curing period, and superplasticizer. According to the results, the Recurrent Neural Network based on Fractional Order Bat Optimization Algorithm has predicted precise outcomes and trained so fast in comparison with RNN method.by considering the outcomes, the Neural Networks methods are satisfactory mechanisms to evaluate the LWC compressive strength. This can decrease the price and reduce the time of processes in these problems.
Which, who and when? Therapeutic processes in group cognitive behaviour therapy for anxiety disorders
Authors: Luong Hoang K. , Roberge Pasquale , Provencher Martin D. , Kilby Christopher J. , Drummond Sean P. A. , Norton Peter J. 
Published: April 2022

AbstractThe evidence for the effect of therapeutic alliance in group cognitive behaviour therapy (CBT) for anxiety disorders is unclear. Identifying whether the alliance–outcome relationship depends on (1) which components are assessed, (2) who is measuring the alliance and (3) when the alliance is measured will help to clarify the role of the client–therapist relationship in therapy. The present study explored the effects of alliance component (agreement vs. bond), rater perspective (client vs. therapist) and timing (early vs. late therapy) on the alliance–outcome relationship. Individuals with an anxiety disorder enrolled into transdiagnostic group CBT were studied, with n = 78 at early therapy and n = 57 at late therapy. Results showed that greater client‐rated agreement significantly predicted improved post‐treatment outcomes throughout the course of therapy, while stronger client‐rated bond in late therapy predicted reduced treatment gains. In contrast, therapist perceptions of agreement and bond were not associated with post‐treatment outcomes at any point in therapy. Client‐reported group cohesion also was not associated with additional variance in outcome after accounting for client‐rated alliance. Overall, the findings highlight the importance of prioritizing the client's perception of the client–therapist relationship in CBT for anxiety disorders, as well as distinguishing the effects of component, rater and timing in future process–outcome studies.
Characterization of Complex Drug Formulations Using Cryogenic Scanning Electron Microscopy (Cryo‐SEM)
Authors: Liang Jing , Koo Bonhye , Wu Yong , Manna Soumyarwit , Noble Jade M. , Patel Mehulkumar , Park Jin H. , Kozak Darby , Wang Yan , Zheng Jiwen 
Published: April 2022

AbstractThe physicochemical properties of complex drug formulations, including liposomes, suspensions, and emulsions, are important for understanding drug release mechanisms, quality control, and regulatory assessment. It is ideal to characterize these complex drug formulations in their native hydrated state. This article describes the characterization of complex drug formulations in a frozen‐hydrated state using cryogenic scanning electron microscopy (cryo‐SEM). In comparison to other techniques, such as optical microscopy or room‐temperature scanning electron microscopy, cryo‐SEM combines the advantage of studying hydrated samples with high‐resolution imaging capability. Detailed information regarding cryo‐fixation, cryo‐fracture, freeze‐etching, sputter‐coating, and cryo‐SEM imaging is included in this article. A multivesicular liposomal complex drug formulation is used to illustrate the impact of different cryogenic sample preparation conditions. In addition to drug formulations, this approach can also be applied to biological samples (e.g., cells, bacteria) and soft‐matter samples (e.g., hydrogels). © Published 2022. This article is a U.S. Government work and is in the public domain in the USA.Basic Protocol 1: Cryo‐fixation to preserve the native structure of samples using planchettesAlternate Protocol: Cryo‐fixation to preserve the native structure of biological samples on sapphire disksBasic Protocol 2: Sample preparation for cross‐sectional cryo‐SEM imagingBasic Protocol 3: Cryo‐SEM imaging and microanalysis
Adults' narratives of positive and negative conflicts
Authors: Tamm Anni , Tõugu Pirko 
Published: April 2022

AbstractThe study aimed to find out which features of conflict contribute to making it a positive experience and which features lead to conflict being evaluated negatively. The sample included 65 adults who provided narratives of positive and negative conflicts. The narratives of positive and negative conflicts were similar in the context and topics: Adults most frequently narrated about conflicts at work and in close relationships that were about differences in values, relationship issues, and resources. The findings suggest that desirable outcomes contribute most strongly to conflicts being viewed positively. In narratives about negative conflicts, participants described undesirable outcomes, but also the conflict process and negative emotions. The behavior of the conflict parties and reaching a solution were the two specific features determining whether the conflict was viewed as positive or negative. The findings have practical implications for improving conflict resolution.
Integrated Cascade Process for the Catalytic Conversion of 5‐Hydroxymethylfurfural to Furanic and TetrahydrofuranicDiethers as Potential Biofuels
Authors: Fulignati Sara , Antonetti Claudia , Tabanelli Tommaso , Cavani Fabrizio , Raspolli Galletti Anna Maria 
Published: April 2022

AbstractThe depletion of fossil resources is driving the research towards alternative renewable ones. Under this perspective, 5‐hydroxymethylfurfural (HMF) represents a key molecule deriving from biomass characterized by remarkable potential as platform chemical. In this work, for the first time, the hydrogenation of HMF in ethanol was selectively addressed towards 2,5‐bis(hydroxymethyl)furan (BHMF) or 2,5‐bis(hydroxymethyl)tetrahydrofuran (BHMTHF) by properly tuning the reaction conditions in the presence of the same commercial catalyst (Ru/C), reaching the highest yields of 80 and 93 mol%, respectively. These diols represent not only interesting monomers but strategic precursors for two scarcely investigated ethoxylated biofuels, 2,5‐bis(ethoxymethyl)furan (BEMF) and 2,5‐bis(ethoxymethyl)tetrahydrofuran (BEMTHF). Therefore, the etherification with ethanol of pure BHMF and BHMTHF and of crude BHMF, as obtained from hydrogenation step, substrates scarcely investigated in the literature, was performed with several commercial heterogeneous acid catalysts. Among them, the zeolite HZSM‐5 (Si/Al=25) was the most promising system, achieving the highest BEMF yield of 74 mol%. In particular, for the first time, the synthesis of the fully hydrogenated diether BEMTHF was thoroughly studied, and a novel cascade process for the tailored conversion of HMF to the diethyl ethers BEMF and BEMTHF was proposed.
Harmonic analysis of VHF resonant converter based on equivalent nonlinear controlled model
Authors: Jiang Xinyi , Chen Yanfeng , Zhang Bo , Qiu Dongyuan , Xie Fan 
Published: April 2022

AbstractLifting operating frequency can effectively reduce the size of energy‐storage components and increase the power density of converters, thus the very high frequency (VHF) resonant converters can find wide applications in practice. In order to further study the characteristics of VHF converters, a modeling method is presented for solving the state variables. First, according to the analysis of a typical VHF converter's operating modes, a unified equivalent circuit is established, which contains nonlinear controlled current sources. Then the mathematical model of the equivalent circuit is derived and solved by using the equivalent small parameter (ESP) method. And the approximate analytical solutions of state variables can be finally obtained, which are composed of a DC component and various harmonics. It is shown that the obtained solutions are accurate enough as the results from the proposed method agree well with the simulations and experimental results. Furthermore, the approximate analytical expressions for harmonics of state variables can be used as a guide for circuit design and stability analysis of the converter.
Targeting transforming growth factor‐ß signalling for cancer prevention and intervention: Recent advances in developing small molecules of natural origin
Authors: Tewari Devesh , Priya Anu , Bishayee Anusha , Bishayee Anupam 
Published: April 2022

BackgroundCancer is the world's second leading cause of death, but a significant advancement in cancer treatment has been achieved within the last few decades. However, major adverse effects and drug resistance associated with standard chemotherapy have led towards targeted treatment options.ObjectivesTransforming growth factor‐ß (TGF‐ß) signalling plays a key role in cell proliferation, differentiation, morphogenesis, regeneration, and tissue homeostasis. The prime objective of this review is to decipher the role of TGF‐ß in oncogenesis and to evaluate the potential of various natural and synthetic agents to target this dysregulated pathway to confer cancer preventive and anticancer therapeutic effects.MethodsVarious authentic and scholarly databases were explored to search and obtain primary literature for this study. The Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) criteria was followed for the review.ResultsHere we provide a comprehensive and critical review of recent advances on our understanding of the effect of various bioactive natural molecules on the TGF‐ß signalling pathway to evaluate their full potential for cancer prevention and therapy.ConclusionBased on emerging evidence as presented in this work, TGF‐ß‐targeting bioactive compounds from natural sources can serve as potential therapeutic agents for prevention and treatment of various human malignancies.
Performance improvement of Routing Protocol for Low‐Power and Lossy Networks protocol in an Internet of Things‐based smart retail system
Authors: Nazaralipoorsoomali Mohammad , Asghari Parvaneh , Javadi Seyyed Hamid Haj Seyyed 
Published: April 2022

SummaryThe Internet of Things (IoT) technology improvement has led to concepts such as smart retail and supply chain management systems. The main problem with IoT‐based smart retail and supply chain management systems is the need for a high‐speed network for responding quickly to many transactions within the network. If the network is not able to respond to all transactions quickly, it will not be possible to handle all requests in time. Also, the network must be stable and reliable to ensure that all requests are received and answered. And finally, they must have a very low power consumption metric to reduce costs. This paper suggests a Multi‐Sink Routing Protocol for Low‐Power and Lossy Networks (RPL) topology for network node placement to achieve network performance improvement. The proposed topology is modeled in a simulated environment using an Instant Contiki operating system by Cooja simulator and is evaluated regarding the different performance metrics including packet delivery ratio (PDR), power consumption, node participation, and control traffic overhead. Also, the network behavior is analyzed by the Wireshark tool. The results show achieving better performance and improving the level of confidence.
Evaluating sources of bias in pedigree‐based estimates of breeding population size
Authors: White Shannon L. , Sard Nicholas M. , Brundage Harold M. , Johnson Robin L. , Lubinski Barbara A. , Eackles Michael S. , Park Ian A. , Fox Dewayne A. , Kazyak David C. 
Published: April 2022

AbstractApplications of genetic‐based estimates of population size are expanding, especially for species for which traditional demographic estimation methods are intractable due to the rarity of adult encounters. Estimates of breeding population size (NS) are particularly amenable to genetic‐based approaches as the parameter can be estimated using pedigrees reconstructed from genetic data gathered from discrete juvenile cohorts, therefore eliminating the need to sample adults in the population. However, a critical evaluation of how genotyping and sampling effort influence bias in pedigree reconstruction, and how these biases subsequently influence estimates of NS, is needed to evaluate the efficacy of the approach under a range of scenarios. We simulated a model system to understand the interactive effects of genotyping and sampling effort on error in genetic pedigrees reconstructed from the program COLONY. We then evaluated how errors in pedigree reconstruction influenced bias and precision in estimates of NS using three different rarefaction estimators. Results indicated that pedigree error can be minimal when adequate genetic data are available, such as when juvenile sample sizes are large and/or individuals are genotyped at many informative loci. However, even in cases for which data are limited, using results of the simulation analysis to understand the magnitude and sources of bias in reconstructed pedigrees can still be informative when estimating NS. We applied results of the simulation analysis to evaluate S for a population of federally endangered Atlantic sturgeon (Acipenser oxyrinchus oxyrinchus) in the Delaware River, USA. Our results indicated that NS is likely to be three orders of magnitude lower compared with historic breeding population sizes, which is a considerable advancement in our understanding of the population status of Atlantic sturgeon in the Delaware River. Our analyses are broadly applicable in the design and interpretation of studies seeking to estimate NS and can help to guide conservation decisions when ecological uncertainty is high. The utility of these results is expected to grow as rapid advances in genetic technologies increase the popularity of genetic population monitoring and estimation.
MALDI‐MS/MS of N‐Terminal TMPP‐Acyl Peptides: A Worthwhile Tool to Decipher Protein N‐Termini
Authors: Fernandez Bernard , Armengaud Jean , Subra Gilles , Enjalbal Christine 
Published: April 2022

AbstractN‐terminal derivatization of proteins with permanently positive charged reagent constitutes a viable mass spectrometry bottom‐up strategy for systematic confident identification of protein N‐termini. Although shotgun nanoLC‐ESI‐MS/MS approaches are commonly applied in that context by dissociating multiply charged molecular ions upon low energy collision‐induced dissociations (CID), we were keen to investigate an alternative sequencing method reckoning on more comprehensive high energy charge remote fragmentations (CRF) available with a MALDI‐Tof/Tof instrument. Hence, two tunable activation methods, i. e. metastable laser‐induced dissociations (LID) and high energy CID, were applied to several synthetic N‐terminal tris(trimethoxyphenyl)phosphonium (TMPP) acetyl peptides and their MS/MS behaviors were compared with low energy CID MS/MS data (LC‐ESI‐QqTof equipment). The amino acid composition was found to play a significant role in the peptide backbone dissociation pathways of these fixed singly charged ions. Proline, arginine, aspartic acid, glutamic acid, but also surprisingly aliphatic residues were impacting the expected sequence fragmentation pattern.
Total Synthesis of Bulgarein
Authors: Swieca Patrick , Spiteller Peter 
Published: April 2022

AbstractHere we report an efficient and short total synthesis of bulgarein (1), a natural compound from Bulgaria inquinans with cytotoxic activity. Key steps in the total synthesis are a Suzuki‐Miyaura coupling reaction of two substituted naphthalene derivates followed by a polyphosphoric acid (PPA) mediated condensation reaction to form the benzo[j]fluoranthene skeleton. Bulgarein (1) was achieved over 4 steps with an overall yield of 25 %.
Dearomatization of Nitro(hetero)arenes through Annulation
Authors: Wang Ning , Ren Jing , Li Kaizhi 
Published: April 2022

AbstractDearomatization reactions employing simple aromatic compounds have showcased remarkable progress in the recent decade and have emerged as one of the most straightforward and powerful tools for the creation of highly functionalized, three‐dimensional molecular frameworks commonly encountered in medicinal chemistry and life sciences. Among the aromatic compounds in use, nitro(hetero)arenes, which feature a less pronounced aromatic character due to the presence of highly electron‐withdrawing nitro group, have been extensively used in different types of dearomatization reactions. The dearomative annulation reaction serves as a powerful and versatile method for the construction of complex polycyclic systems. This overview presents a brief summary of recent impressive advances in nitro(hetero)arenes dearomative annulation and provides some inspirations for future research.
Accurately predicting transport properties of porous fibrous materials by machine learning methods
Authors: Cawte Taylr , Bazylak Aimy 
Published: April 2022

AbstractMachine learning algorithms trained on data gathered from stochastically generated gas diffusion layers (GDLs) were used to predict key transport properties that govern effective mass transport behaviour in polymer electrolyte membrane fuel cells. Specifically, we present the largest database in the present literature of stochastically generated fibrous GDL substrates (containing over 2000 unique materials) and the associated structural and transport properties determined via pore network modelling. Seven established machine learning algorithms were trained to predict the effective single‐phase permeability (ksp) and diffusivity (Dsp), and the relative permeability (kr) and diffusivity (Dr) of the generated materials using well‐defined material properties as input features. Gradient boosting regression (GBR), artificial neural network, and support vector regression were the best performing predictors of the single‐phase properties, all of which exhibited statistically insignificant differences in error. GBR provided the best prediction accuracy of relative transport properties.
Studies on energy storage properties of BFO/WO3 bilayer thin film capacitor
Authors: Lamichhane Shiva , Sharma Savita , Tomar Monika , Chowdhuri Arijit 
Published: April 2022

AbstractPresent work reports the growth of BFO/WO3 bilayer thin film structures over Silicon, corning and ITO coated glass substrates. BFO layer in BFO/WO3 bilayer structure was deposited using Pulsed Laser deposition (PLD) technique at optimized laser energy (200 mJ) while WO3 nanostructured layer was deposited using rf‐magnetron sputtering technique at varying glancing angle from 65° to 80°. For the realization of MBM (metal‐bilayer‐metal) device, top Gold (Au) electrodes have been deposited using thermal evaporation technique. The BFO/WO3 bilayer structure fabricated at 70° glancing angle exhibited the saturation (Ps) and remnant (Pr) polarization as 45.45 μC/cm2 and 21.52 μC/cm2 respectively, which are appreciably higher than the earlier reports for pure BFO thin films. Enhanced energy storage characteristics were obtained in Au/BFO/WO3/ITO structure fabricated at 70° glancing angle with charge‐discharge efficiency (63%) and enlarged recoverable energy density (467 mJ/cm3). Achieved results indicate the utilization of fabricated Au/BFO/WO3/ITO structures towards high energy storage applications.
Effect of nanocomposite alginate‐based film incorporated with cumin essential oil and TiO2 nanoparticles on chemical, microbial, and sensory properties of fresh meat/beef
Authors: Sayadi Mehran , Mojaddar Langroodi Ali , Amiri Sedigheh , Radi Mohsen 
Published: April 2022

AbstractThe environmental problems of synthetic plastics in food packaging have led researchers to synthesize biodegradable films. In this study, nanocomposite alginate‐based films containing TiO2 nanoparticles (1%) and cumin essential oil (CEO, 2%) were fabricated and the potential of these films to protect beef from chemical [pH, total volatile base nitrogen (TVBN), peroxide value, and thiobarbituric acid reactive substances (TBA)] and microbial [total viable count, Enterobacteriaceae, lactic acid bacteria, Listeria monocytogenes, and Pseudomonas spp.] spoilage was evaluated during 24 days of storage (4°C). The active films significantly induced the reduction in lipid oxidation, microbial growth, and TVBN values, improved the sensory attributes of treated samples, maintained the redness of meats for a longer time, and increased the shelf life of beef from 4 to 16 days. The results of this study showed that TiO2/CEO alginate‐based nanocomposite film has a great potential for application in meat and meat products.