bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer Effects of Herbal Medicines in Pancreatic Cancer Through Modulation of Steroid Hormone Response Proteins
Authors: Zhang Zhiyi , Wang Juan , Liu Bingying , Liu Yu , Shi Xiaowei , Li Wenli , Xin Huawei , Xin Jie , Hao Chunxiang 
Published: March 2022

Abstract
Many individual herbs and herbal formulae have been demonstrated to provide safe and effective treatment for Pancreatic cancer (PC); however, the therapeutic mechanisms underlying their effects have not been fully elucidated. A total of 114 herbal formulae comprising 216 single herbal medicines used to treat PC were identified. Cluster analysis revealed a core prescription including four herbs [Glycyrrhizae Radix et Rhizome (Gan Cao), Codonopsis Radix (Dang Shen), Citri Reticulatae Pericarpium (Chen Pi), and Pinelliae Rhizoma (Ban Xia)] in combination to treat PC, and 295, 256, 141, and 365 potential targets were screened for each of these four herbs, respectively. PC-related proteins (n = 2940) were identified from the DisGeNET database. Finally, 44 overlapping targets of herbs and PC were obtained, representing potential targets of the herbal medicines for PC treatment. GO enrichment analysis indicated that targets common to herbs and PC primarily functioned in response to steroid hormones. KEGG pathway enrichment analysis indicated that the herbs may prevent PC by influencing apoptotic, p53, and PI3K/Akt signaling pathways. Further, molecular docking analysis indicated that of identified bioactive compounds, stigmasterol, phaseol, perlolyrine, shinpterocarpin, and licopyranocoumarin have good binding ability with proteins involved in responses to steroid hormones, while stigmasterol, phaseol, perlolyrine, and DIOP have good binding ability with PTGS2(also known as COX-2), ESR1, ESR2, AR, and PGR. Conclusion: The anti-PC activity of herbal medicines may be mediated via regulation of proteins with roles in responses to steroid hormones. This study provides further evidence supporting the potential for use of herbal medicines to treat PC.
Incidentalomas Are Associated With an Increase in Liver Transplantation in Patients With Cirrhosis: A Single-Center Retrospective Study
Authors: Cortés Pedro , Ghoz Hassan M. , Stancampiano Fernando , Omer Mohamed , Malviya Balkishan , Bowman Andrew W. , Palmer William C. 
Published: March 2022

Abstract
Background: Incidentalomas, defined as incidental findings on imaging, are a growing concern. Our aim was to determine the impact and outcomes of extrahepatic incidentalomas on liver transplantation.Methods: Patients at a large liver transplant center, who had an initial MRI for hepatocellular carcinoma screening between January 2004 and March 2020 were identified. Clinical data were collected retrospectively. Survival analysis, utilizing Kaplan Meier estimates and Cox proportional hazards regression analysis, was utilized to determine factors associated with liver transplantation. Results: 720 patients were included. NASH (24.9%), HCV (22.1%) and alcohol (20.6%) were the most common causes of cirrhosis. 79.7% of patients had an extrahepatic incidentaloma. Older age and having received a liver transplant by the end of the study were associated with an incidentaloma. MELD was not associated with the presence of an incidentaloma. On univariate Cox proportional hazards regression, male gender, history of moderate alcohol use, smoking history, MELD, and incidentalomas were predictors of liver transplantation. On multivariate analysis, only MELD and the presence of an incidentaloma were found to be significant. Discovery of an incidentaloma was associated with a 30% increase in the risk of liver transplantation. Median time to transplantation did not differ based on the presence on an incidentaloma. Patients with cirrhosis from alcohol or HCV had a significantly shorter median time to transplantation than those with NASH. Renal and pancreatic lesions comprised 91% of all incidentalomas.Conclusions: In this single-center retrospective study, extrahepatic incidentalomas were common in patients with cirrhosis. The finding of an incidentaloma was associated with a higher risk of liver transplantation despite a similar median time to transplantation if no incidentaloma was discovered.
The First Case of Jujube allergy presented as anaphylaxis in a child sensitized multiple food allergens: A case report
Authors: Kang Tae Seok , Kim Hana , Suh In Bum , Kim JaKyoung 
Published: March 2022

Abstract
Background: Chinese jujube fruits, called daechu in Korea, have high nutritional and medical value and are consumed worldwide as fresh and dry fruit, but there are few reports of side effects or allergies. Case presentation: We present the first child’s case, having anaphylaxis to this fruit in a patient with no latex allergy, but other food allergy such as pine nuts and kiwi. We took the examination using skin prick test specific immunoglobulin E (IgE) with unicap and indirect enzyme-linked immunosorbent assay (ELISA) to confirm the sensitization of the causative allergen. In the skin test, the result of latex and jujube was negative, and Unicap specific IgE tests for kiwi and pine nut were 2.34 kU/L and 2.87 kU/L, and 0.55 O.D and 0.87 O.D (control group 0.36, 0.4) by indirect ELISA to kiwi and pine nut that we performed. The result of our performing indirect ELISA to jujube was positive as 0.62 O.D. (Control group 0.41). Conclusions: It is thought that research on allergenicity of jujube and the cross-relationship between jujube allergy antigen and food allergens such as kiwi or pine nuts will be necessary in the future.
Effects of Polysaccharide from Hericium Erinaceus on Diarrhea Rats Induced by Lincomycin Hydrochloride: A Potential Treatment for Gut Microbiota Dysbiosis
Authors: Li Shanshan , Ren Duoduo , Tan Shaochao , Qi Yuli , Sun Yinshi 
Published: March 2022

Abstract
In China, the fungus Hericium erinaceus is known as a healthy food crop which possesses digestive tract protection functionality. This research was focus on the effects of polysaccharides extracted from Hericium erinaceus (WHP) on rats with diarrhea induced by antibiotic, specifically on the shifts of gut microbiota. WHP was mainly composed of glucose (88.6%), galactose (9.1%), and fructose (2.3%). It decreased the disease activity index, structure damage of the colon in rats with AAD; increased butyrate production, and affected the gut microbiota through increase the relative abundance of Lactobacillus and Butyricicoccus, while decreased that of Allobaculum and Enterococcus, which closely related to the gut microbiota dysbiosis. It could concluded from this study that WHP can ameliorate antibiotic induced diarrhea by causing the recovery of the colon damage, improving the gut microbiota dysbiosis, and promoting the butyrate production. The results of this study can provide valuable data on how Hericium erinaceus polysaccharide alleviate the damage associated to the intake of antibiotics.
Validation, Reliability and Repeatability of the Ocular Surface Disease Index (OSDI) Questionnaire in a Sample of the Palestinian Population: The Pa-OSDI
Authors: Azemin Mohd Zulfaezal Che , Aljarousha Mohammed , Badarudin Noor Ezailina , Aljeesh Yousef , Amer Abuimara , Rahim Muhammed Afzam Abdul 
Published: March 2022

Abstract
PURPOSE To translate and validate a Palestinian dialect version of OSDI. METHODS The translation procedure included five stages; forward translation, revision of translation, backward translation, refinement of translation and finally test of the pre-final version. The final sets of questionnaires were constructed using an online JotForm platform. The online platform was chosen to automatically calculate the questionnaire's final overall score. Overall, 260 participants were instructed to fill out the English and the Pa-OSDI version twice to conduct the reliability of the translated version and repeatability evaluation. RESULTS The mean age of the participants was 33.45±11.74 years. Cronbach's alpha for all domains was greater than 0.80, except the ‘‘blurred vision’’ and ‘‘deteriorating vision’’ domains (0.77 and 0.74 respectively). The mean overall score difference between the OSDI and Pa-OSDI was 0.86 based on the Bland-Altman chart. For repeatability, no significant difference in the overall scores between the two repeats of the Pa-OSDI ( p =0.632). The outcome for the Pa-OSDI overall score (sessions 1 and 2) was a clinically difference (bias) of 0.21. By using the Varimax rotation method, only three factors (ocular symptoms, vision-related function, and environmental triggers) had eigenvalues greater than one in the structure of the Pa-OSDI. CONCLUSION The Pa-OSDI is an appropriate reliable and repeatable tool for the determination of dry eye symptoms, ocular discomfort and quality of life in the Palestinian dialect speaking population. This version could remove the language barrier in answering OSDI domains more easily.
Glucose oxidase converted into a general sugar-oxidase
Authors: Baruch-Shpigler Yael , Avnir David 
Published: March 2022

Abstract
Entrapment of glucose oxidase (GOx) within metallic gold converts this widely used enzyme into a general saccharide oxidase. The following sugar molecules were oxidized by the entrapped enzyme (in addition to D-glucose): L-glucose, fructose, xylose,, glucose-6-phosphate, sucrose, lactose, methylglucoside, and the tri-saccharide raffinose. None of these sugars except raffinose has a natural specific oxidase. The origin of this generalization of activity is attributed to the strong protein-gold 3D interactions and to the strong interactions of co-entrapped cetyltrimethylammonium bromide (CTAB) with gold on one hand, and with the protein on the other hand. It is proposed that these interactions induce conformational changes in the channel leading to the active site, which is located at the interface between the two units of the dimeric GOx protein. The observations are compatible with affecting the specific conformation change of pulling apart and opening this gate-keeper, rendering the active site accessible to a variety of substrates. In addition to converting a common enzyme to an oxidase for common sugars which lack it, the entrapment methodology was found to be beneficial in increasing the thermal stability of GOx up to 100 oC and in allowing its convenient recyclability, two features of practical importance.
MSC-EVs: A Promising Modulator for Immune Response in Systemic Lupus Erythematosus
Authors: Xie Min , Wen Chuan , Li Cuifang , She Zhou , Wu Feifeng , Mao Jueyi , Hun Marady , Luo Senlin , Wan Wuqing , Tian Jidong 
Published: March 2022

Abstract
At present, human umbilical cord mesenchymal stem cells(hUCMSCs) have been used in the clinical treatment of systemic lupus erythematosus(SLE), However, the detailed mechanism of MSCs remains unclear. In this study, we investigated whether hUCMSCs derived extracellular vesicles (hUCMSC-EVs) could regulate abnormal immune responses of T cells or B cells in SLE.We isolated splenic mononuclear cells from MRL/lpr mice , a classical animal model of SLE.PBS(Phosphate-buffered saline), 2×105 hUCMSCs, 25µg/ml hUCMSC-EVs, 50µg/ml hUCMSC-EVs were co-cultured with 2×106 activated splenic mononuclear cells for 3 days in vitro, respectively. The proportions of CD4+T cell subsets and the concentrations of cytokines were detected .Both hUCMSCs and hUCMSC-EVs inhibited CD4+T cells , increased the production of T helper(Th)17 cells , promoted the production of interleukin（IL）-17 and transforming growth factor beta 1(TGF-β1) (P＜0.05), although they had no significant effects on Th1, Th2, T follicular helper (Tfh), regulatory T (Treg )cells and IL-10 (P＞0.05);only hUCMSCs inhibited CD19+ B cells, promoted the production of interferon-gamma (IFN-γ) and IL-4 (P＜0.05).hUCMSCs exert immunoregulatory effects on SLE at least partially through hUCMSC-EVs in vitro, hUCMSC-EVs play novel and potential regulator roles in SLE.
Ameliorative Effect of Nanocurcumin and/or Saccharomyces Cell Wall Against Aflatoxicosis in Broilers
Authors: Ashry Aya , Taha Nabil M. , Lebda Mohamed A. , Abdo Walied , El-Diasty Eman M. , Fadl Sabreen E. , Elkamshishi Mohammed Morsi 
Published: March 2022

Abstract
Background
The adverse effect of aflatoxin in broilers well known. However, dietary supplementation of nanocurcumin and/or Saccharomyces cell wall may decrease the bad effect of aflatoxin B1 because of their bio-adsorbing feature of the functional ingredients in Yeast Cell Wall and the detoxification effect of curcumin nanoparticles. The goal of this study was to see how nanocurcumin and/or Saccharomyces cell wall supplementation and/or aflatoxin affected broiler development, blood and serum parameters, carcass trait, histology, immune histochemistry, liver gene expression, and aflatoxin residue in the liver and muscle tissue of broilers. Broiler chicks with one day old were distributed into five groups according to nanocurcumin and/or saccharomyces cell wall with aflatoxin supplementation. The G1 group was given a formulated diet without any supplements. The G2 group was supplemented with aflatoxin (0.25 mg/kg diet) in the formulated diet. The G3 group was supplemented with aflatoxin (0.25 mg/kg diet) and Saccharomyces cell wall (1Kg/Ton diet) in the formulated diet. The G4 group was supplemented with aflatoxin (0.25 mg/kg diet) and nanocurcumin (400 mg/kg) in the formulated diet. The G5 group was supplemented with aflatoxin (0.25 mg/kg diet) and Saccharomyces cell wall (1Kg/Ton diet) with nanocurcumin (200 mg/kg) in the formulated diet.
Results
Aflatoxin supplementation had a detrimental impact on the growth performance, blood and serum parameters, carcass trait, and aflatoxin residue in the liver and muscle tissue of broilers, according to the results of this study. In addition, aflatoxin supplementation led to a liver injury that was indicated by serum biochemistry and pathological lesions in the liver tissue. Moreover, the intestinal villi, length, and width were affected. The expression of some genes in the liver tissue was affected.
Conclusion
Saccharomyces cell wall alone or with nanocurcumin attenuated these negative effects and anomalies, and improving all of the above-mentioned metrics.
Latent Toxoplasma, schizophrenia, and depression: a case study in urban Ecuador
Authors: Moreno Diego Ferdinand Rosado , Santacruz Evelyn Carolina Loor , Zambrano Jorge David Ávila , Mosquera Larissa Villacrés , Alvarez Maria Belen Intriago , Orellana Mario Alberto Sotomayor , Chavez Flor Maria Alcivar , Santos Shanny Estefania Toral , Figueroa Nicole Gabriela Sanchez 
Published: March 2022

Abstract
Background:In recent years several research projects around the world have aimed to determine a possible infectious origin of schizophrenia, where a higher prevalence of Immunoglobin G antibodies against Toxoplasma has been observed in these patients. Differences in symptoms between infected and non-infected patients have also been described. Finding the link between Toxoplasma and Schizophrenia is a complex challenge that requires further research which will allow better treatment options, symptoms improvement and quality of life. Methods:Search of differences on symptomatology was performed by studying 104 patients diagnosed with schizophrenia from the Institute of Neurosciences of the city of Guayaquil, who underwent ELISA testing to detect Immunoglobin G against Toxoplasma gondii. Results:Of these 104 samples, 90 were positive, obtaining an 86.5% prevalence. Thirteen symptoms were taken from clinical notes, where the infection with Toxoplasma gondii was found to be a protective factor for schizophrenia patients against depressionConclusion:These findings add evidence to previous reports that latent Toxoplasma may protect against depression in patients with schizophrenia.
Landslides Mapping and Design of IoT-based Susceptibility Prediction System: A Case Study of Bududa District in Uganda
Authors: Badru Lusiba , Twaib Semwogere , Oguti Victoria , Bongomin Ocident , Ocen Gilbert Gilibrays 
Published: March 2022

Abstract
Landslides are a serious geologic hazard common in the Eastern and western hilly parts of Uganda. Landslides have caused large numbers of casualties and huge economic losses in hilly and mountainous areas of the Uganda. Landslide investigations in Mount Elgon areas can be traced back to about two decades. These investigations have focused mainly on landslide cause-effect relationship, triggering mechanism, people’s perceptions of landslide disasters, and vulnerability. No attempt has been made by scholars to monitor, watch, and warn about the events of landslides in the Elgon areas involving modern technology and hence automate the prediction of landslide susceptibility. A pretty good landslide hazards prevention program is needed to address the awareness of several fundamental aspects of landslides thus, seeks answers to such questions as; where and when will landslides occur? how big will they be? Hence watch and warning are key services of any landslide hazard prevention system. ArcGIS was acquired and preliminary mapping of landslide prone sites was done partially, GIS images and maps were extracted from ArcGIS software for analysis. The digital elevation model (DEM) of the study area was produced. The images extracted were for the areas prone to landslides and further analysis is done. The parameters like soil pore pressure, soil vibration, soil movement, rain intensity, humidity and soil characteristics are studied to establish their threshold values for landslide occurrences, the high lands of Bududa district in Eastern Uganda was taken as a case study. A design of IoT system to monitor the area and report the possibility is done. The system has the ability to report on landslide indicators, people are notified by a text or audio massage on devices connected on to the internet.
Challenge of 2D representation of 3D objects in architectural and heritage studies. In search of gaze patterns similarities
Authors: Rusnak Marta 
Published: March 2022

Abstract
This paper describes the results of eye-tracking registrations using spherical stimuli related to the so-called longitudinal church effect and compared it to those obtained by using a stationary eye-tracker and pictures shown on a computer screen in previous studies. The data collected from nearly 120 viewers allowed to investigate the effect of length of the nave on concentration on the altar and its role in supporting the ritual. An important aspect of this study is that it compares three pairs of stimuli and their relationships, rather than just two examples. The experiment with flat images in many respects gave results like those obtained in virtual reality. Even though the values on which the conclusions were based differed, 11 out of 14 analyzed aspects were confirmed. An important difference observed in VR was a noticeable decrease in the average duration of fixation. Thanks to the presented comparison it can be assumed that there is no need to involve VR technology if the studied phenomena are simple and the most important elements of linear compositions are visible in a single glance. If eye-tracking tests conducted with stationary eye-trackers do not have any other flaws, the conclusions drawn from them can be trusted.
Development and Validation of an Early Warning Model for Hospitalized COVID-19 Patients: A Multi-center Retrospective Cohort Study
Authors: Smit J. M. , Krijthe J. H. , Tintu A. N. , Endeman H. , Ludikhuize J. , Genderen M. E. Van , Hassan S. , Moussaoui R. El , Westerweel P. E. , Goekoop R. J. , Waverijn G. , Verheijen T. , Hollander J. G. Den , De Boer M.G.J. , Gommers D. A.M.P.J. , Vlies R. Van der , Schellings M. , Carels R. A. , Nieuwkoop C. Van , Arbous M. S. , Bommel J. Van , Knevel R. , De Rijke Y. B. , Reinders M. J.T. 
Published: March 2022

Abstract
Background: Timely identification of deteriorating COVID-19 patients is needed to guide changes in clinical management and admission to intensive care units (ICUs). There is significant concern that widely used early warning scores (EWSs) underestimate illness severity in COVID-19 patients and therefore, we developed an early warning model specifically for COVID-19 patients.Methods: We collected electronic medical record data to extract predictors and used these to fit a random forest model. To simulate the situation in which the model would have been developed after the first COVID-19 ‘wave’ in the Netherlands and implemented during the second wave, we performed a temporal validation by splitting all included patients into groups admitted before and after August 1, 2020. Furthermore, we propose a method for dynamic model updating to retain the model’s predictive performance over time. We evaluated model discrimination and calibration, performed a decision curve analysis, and quantified the importance of predictors using SHapley Additive exPlanations values.Findings: We included 3 514 COVID-19 patient admissions from six Dutch hospitals between February 2020 until May 2021, and included a total of 18 predictors for model fitting. The model showed a higher discriminative performance in terms of partial area under the receiver operating characteristic curve (0.82 [0.80 to 0.84]) compared to the National Early Warning Score (0.72 [0.69 to 0.74]) and the Modified Early Warning Score (0.67 [0.65 to 0.69]), a greater net benefit over a range of clinically relevant model thresholds, and good calibration (intercept=0.03 [-0.09 to 0.14], slope=0.79 [0.73 to 0.86]).Interpretation: Thisstudyshowsthepotentialbenefitofmovingfromearlywarningmodelsforthegeneralinpatientpopulationtomodelsforspecificpatientgroups. The COVID-19-specific early warning model is available online at https://github.com/jimmsmit/COVID-19_EWSandweencourageotherstofurther validate this model independently.
Modeling for Agriculture Irrigation Quality Index of the Iran in Southern Catchment Basin of Namak Lake Using Ad-Hoc, Expert Researches Awards Approach and Fuzzy-Statistical Methods
Authors: Samadi Javad 
Published: March 2022

Abstract
Modeling and surveying the quality of agriculture irrigation is essential for management, site selection, land allocation and development of agriculture activities, water quality and quantity monitoring system, and protection of water resources and prevention the economic risks of agricultural products. In this study, following 15 parameters: Potential Salinity (PS), Electrical Conductivity (EC), Sodium Adsorption Ratio (SAR), Soluble Sodium Percentage (SSP), Kelly's Ratio (KR), Residual Sodium Carbonate (RSC), Magnesium Adsorption Ratio (MAR), Kalium Hazard (KH), Permeability Index (PI), Lime Deposition Potential (LDP), potential of Hydrogen (pH), Total Hardness (TH), Bicarbonate Content (BC), Chloro-Alkaline Indices (CAI) and Boron Hazard (BH), were used for spatial modeling of agriculture irrigation index. At first, very important and effective parameters on irrigation quality index were identified and the values of the parameters index based on research awards of experts and Ad Hoc system were rated using nonlinear regression and fuzzy-statistical methods. This was performed in such a way that the level and importance of each classes of classification parameters and the final model are considered equivalent and equal to the reclassified classes of agriculture irrigation quality index (AIQI) up to be equalized the parameters weight. The results showed that AIQI index based on the geometric mean of the parameters can demonstrate the highest impact on irrigation quality status and determining the agriculture suitable areas in catchment basin in south of the Namak Lake.