bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lack of phenotypic plasticity in leaf hydraulics for 10 woody species common to urban forests of North China
Authors: Han Hang , Xi Benye , Wang Ye , Feng Jinchao , Li Ximeng , Tissue David T 
Published: January 2022

Abstract
The survival and performance of urban forests are increasingly challenged by urban drought, consequently compromising the sustainability and functionality of urban vegetation. Plant–water relations largely determine species drought tolerance, yet little is known about the hydraulics of urban forest species. Here, we report the leaf hydraulic and carbon traits that govern plant growth and drought resistance, including vulnerability to embolism, hydraulic conductivity and leaf gas exchange characteristics, as well as morphological traits that are potentially linked with these physiological attributes, with the aim of guiding species selection and management in urban forests. Plant materials were collected from mature shrubs and trees on our university campus in Beijing, representing 10 woody species common to urban forests in north China. We found that the leaf embolism resistance, represented by the water potential inducing 50% loss of hydraulic conductivity (P50), as well as the hydraulic safety margin (HSM) defined by P50 and the water potential threshold at the inception of embolism (P12), varied remarkably across species, but was unrelated to growth form. Likewise, stem and leaf-specific hydraulic conductivity (Kstem and kl) was also highly species-specific. Leaf P50 was positively correlated with hydraulic conductivity. However, neither P50 nor hydraulic conductivity was correlated with leaf gas exchange traits, including maximum photosynthetic rate (Amax) and stomatal conductance (gs). Plant morphological and physiological traits were not related, except for specific leaf area, which showed a negative relationship with HSM. Traits influencing plant–water transport were primarily correlated with the mean annual precipitation of species climatic niche. Overall, current common woody species in urban forest environments differed widely in their drought resistance and did not have the capacity to modify these characteristics in response to a changing climate. Species morphology provides limited information regarding physiological drought resistance. Thus, screening urban forest species based on plant physiology is essential to sustain the ecological services of urban forests.
Root age-related response of fine root respiration of Chinese fir seedlings to soil warming
Authors: Wang Xiaohong , Xu Chensen , Xiong Decheng , Yao Xiaodong , Chen Tingting , Jiang Qi , Jia Linqiao , Fan Ailian , Chen Guangshui 
Published: January 2022

Abstract
The variation in fine root respiration with root age provides insight into root adaptation to climate warming, but the mechanism is poorly understood. In this study, we investigated the respiratory response of fine roots (&lt;1 mm and 1–2 mm) of different ages (2-, 4- and 6-month old) of Chinese fir (Cunninghamia lanceolata (Lamb.)) seedlings to soil warming (4 °C above the control using cable heating). Fine roots were excised to measure the specific respiration rate at a reference temperature of 20 °C (SRR20), and root morphological and chemical traits were measured. Soil warming significantly increased SRR20 by 40% compared with the control, potentially indicating limited acclimation on a short time scale (6 months). However, soil warming increased SRR20 significantly in 2-month-old roots (by 72%) compared with 4- and 6-month-old roots, leading to a steeper decline in SRR20 with root age. This result suggests possible increased nutrient uptake efficiency in young fine roots under warmer temperatures. Soil warming significantly increased specific root length (SRL) but not root tissue nitrogen concentration (RTN). The variation in SRR20 between warming treatments, but not across root ages, was predicted by SRL and RTN individually or together. Our findings conclusively indicate that soil warming increased the respiration cost of young fine roots, which was predicted by adjusting for SRL and RTN, indicating that Chinese fir may adopt a faster fine root turnover strategy to enhance nutrient uptake and soil exploitation under warmer temperatures. Future studies should simultaneously investigate age-related root respiration and nutrient uptake in warming experiments to better understand the effects of warming on root metabolic activity.
Online Readability Analysis: Mohs Micrographic Surgery Postsurgical Wound Care
Authors: Dowdle Travis S. , Nguyen Jeannie M. , Steadman Jesse N. , Layher Heather , Sturgeon Ashley L. E. , Akin Russell 
Published: January 2022

ABSTRACT

OBJECTIVE
Although various treatment modalities exist for skin cancer care, Mohs micrographic surgery (MMS) is one of the most effective and cosmetically sensitive surgical techniques. The readability of online informational materials specifically related to MMS postsurgical wound care is extremely relevant for patients given the high rates of skin cancer in the US and the number of patients utilizing the internet for information.

METHODS
Investigators conducted Google searches to evaluate the current state of readability on MMS postsurgical wound care using the specific keywords “healing after Mohs surgery” and “wound care Mohs surgery.” The readabilities of individual websites were analyzed using the WebFX online software. Health-specific click-through rate was used to select the number of samples assessed.

RESULTS
Based on the 33 unique websites evaluated, the aggregate readability of online MMS postsurgical wound care materials was 11.3, corresponding to an 11th-grade reading level by US standards.

CONCLUSIONS
Although this level of readability is an improvement in online MMS postsurgical wound care information relative to prior literature, there is still considerable work to be done by the dermatologic community in improving the readability of online patient materials regarding MMS.
Mortality in Early-Onset Scoliosis During the Growth-friendly Surgery Era
Authors: Guzek Ryan H. , Murphy Robert , Hardesty Christina K. , Emans John B. , Garg Sumeet , Smith John T. , Roye Benjamin D. , Glotzbecker Michael P. , Sturm Peter F. , Snyder Brian D. , Poon Selina C. , Poe-Kochert Connie ,   Pediatric Spine Study Group (PSSG), Anari Jason B. 
Published: January 2022

Introduction:
Early-onset scoliosis (EOS) is a spinal deformity that occurs in patients 9 years of age or younger. Severe deformity may result in thoracic insufficiency, respiratory failure, and premature death. The purpose of this study is to describe the modern-day natural history of mortality in patients with EOS.

Methods:
The multicenter Pediatric Spine Study Group database was queried for all patients with EOS who are deceased, without exclusion. Demographics, underlying diagnoses, EOS etiology, operative and nonoperative treatments or observation, complications, and date of death were retrieved. Descriptive statistics and survival analysis with Kaplan-Meier curves were performed.

Results:
There were 130/8009 patients identified as deceased for a registry mortality rate of 16 per 1000 patients. The mean age at death was 10.6 years (range: 1.0 to 30.2 y) and the most common EOS etiology was neuromuscular (73/130, 56.2%; P<0.001). Deceased patients were more likely be treated operatively than nonoperatively or observed (P<0.001). The mean age of death for patients treated operatively (12.3 y) was older than those treated nonoperatively (7.0 y) or observed (6.3 y) (P<0.001) despite a larger deformity and similar index visit body mass index and ventilation requirements. Kaplan-Meier analysis confirmed an increased survival time in patients with a history of any spine operation compared with patients without a history of spine operation (P<0.0001). Operatively treated patients experienced a median of 3.0 complications from diagnosis to death. Overall, cardiopulmonary related complications were the most common (129/271, 47.6%; P<0.001), followed by implant-related (57/271, 21.0%) and wound-related (26/271, 9.6%). The primary cause of death was identified for 78/130 (60.0%) patients, of which 57/78 (73.1%) were cardiopulmonary related.

Conclusions:
This study represents the largest collection of EOS mortality to date, providing surgeons with a modern-day examination of the effects of surgical intervention to better council patients and families. Both fatal and nonfatal complications in children with EOS are most likely to involve the cardiopulmonary system.

Level of Evidence:
Level IV—therapeutic.
How should we measure intraocular pressure in the era of coronavirus disease 2019? Balancing infectious risk, cleaning requirements, and accuracy
Authors: Petersen Christine A. , Chen Andrew , Chen Philip P. 
Published: January 2022

Purpose of review
Accurate and precise measurement of intraocular pressure (IOP) is a vitally important component of the ophthalmic examination. There are multiple methods of tonometry, each of which has considerations in light of the ongoing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. This review discusses these considerations and compares various tonometer methods with the gold standard of Goldmann applanation tonometry (GAT).

Recent findings
The SARS-CoV-2 virus may spread via droplets, microaerosols, or direct contact in the ophthalmology clinic. Tonometry poses a high risk of contamination. The accuracy and reliability of various methods of tonometry with single-use disposable equipment has been compared with Goldmann applanation tonometry.

Summary
Goldmann applanation tonometry with disposable applanation tips, Tono-pen, and iCare employ single use tips to decrease the risk of cross-contamination of infectious agents. Review of the literature demonstrates good correlation between these devices and GAT, although the published level of agreement between devices varies.
Nutrition, defecation, and the lower gastrointestinal tract during critical illness
Authors: McClave Stephen A. 
Published: January 2022

Purpose of review
The goal of this report is to delineate the correlation between constipation as a manifestation of impaired gastrointestinal transit with adverse clinical outcomes, to identify risk factors, which predispose to this condition, and outline a management scheme for prophylactic treatment.

Recent findings
Constipation is common in the ICU, affecting upwards of 60–85% of critically ill patients. As suggested by case series and observational studies, constipation may be an independent prognostic factor identifying patients with greater disease severity, higher likelihood of organ dysfunction, longer duration of mechanical ventilation, prolonged hospital length of stay, and possibly reduced survival. Treating constipation is a low priority for intensivists often relegated to the nursing service, and few ICUs have well designed protocols in place for a bowel regimen. Small randomized controlled trials show improvement in certain outcome parameters in response to a daily lactulose therapy; hospital length of stay, sequential organ failure assessment scores, and duration of mechanical ventilation. However, aggregating the data from these studies in two separate meta-analyses showed that the effect of a bowel regimen on these three endpoints were not statistically different.

Summary
No causal relationship can be determined between constipation and adverse outcomes. Nonetheless, a clinical correlation seems to exist. Whether constipation is an epiphenomenon or simply a reflection of greater severity of critical illness, at some point it may contribute to worsening morbidity in the ICU. A graded prophylactic bowel regimen should help reverse impairment of the gastrointestinal transit and aid in reducing its deleterious impact on the hospital course of the critically ill patient.
Variation in Initiation, Engagement, and Retention on Medications for Opioid Use Disorder Based on Health Insurance Plan Design
Authors: Morgan Jake R. , Quinn Emily K. , Chaisson Christine E. , Ciemins Elizabeth , Stempniewicz Nikita , White Laura F. , Linas Benjamin P. , Walley Alexander Y. , LaRochelle Marc R. 
Published: January 2022

Background:
The association between cost-sharing and receipt of medication for opioid use disorder (MOUD) is unknown.

Methods:
We constructed a cohort of 10,513 commercially insured individuals with a new diagnosis of opioid use disorder and information on insurance cost-sharing in a large national deidentified claims database. We examined 4 cost-sharing measures: (1) pharmacy deductible; (2) medical service deductible; (3) pharmacy medication copay; and (4) medical office copay. We measured MOUD (naltrexone, buprenorphine, or methadone) initiation (within 14 d of diagnosis), engagement (second receipt within 34 d of first), and 6-month retention (continuous receipt without 14-d gap). We used multivariable logistic regression to assess the association between cost-sharing and MOUD initiation, engagement, and retention. We calculated total out-of-pocket costs in the 30 days following MOUD initiation for each type of MOUD.

Results:
Of 10,513 individuals with incident opioid use disorder, 1202 (11%) initiated MOUD, 742 (7%) engaged, and 253 (2%) were retained in MOUD at 6 months. A high ($1000+) medical deductible was associated with a lower odds of initiation compared with no deductible (odds ratio: 0.85, 95% confidence interval: 0.74–0.98). We found no significant associations between other cost-sharing measures for initiation, engagement, or retention. Median initial 30-day out-of-pocket costs ranged from $100 for methadone to $710 for extended-release naltrexone.

Conclusions:
Among insurance plan cost-sharing measures, only medical services deductible showed an association with decreased MOUD initiation. Policy and benefit design should consider ways to reduce cost barriers to initiation and retention in MOUD.
Heterogeneity in the association between weather and pain severity among patients with chronic pain: a Bayesian multilevel regression analysis
Authors: Yimer Belay B. , Schultz David M. , Beukenhorst Anna L. , Lunt Mark , Pisaniello Huai L. , House Thomas , Sergeant Jamie C. , McBeth John , Dixon William G. 
Published: January 2022

Abstract

Introduction:
Previous studies on the association between weather and pain severity among patients with chronic pain have produced mixed results. In part, this inconsistency may be due to differences in individual pain responses to the weather.

Methods:
To test the hypothesis that there might be subgroups of participants with different pain responses to different weather conditions, we examined data from a longitudinal smartphone-based study, Cloudy with a Chance of Pain, conducted between January 2016 and April 2017. The study recruited more than 13,000 participants and recorded daily pain severity on a 5-point scale (range: no pain to very severe pain) along with hourly local weather data for up to 15 months. We used a Bayesian multilevel model to examine the weather–pain association.

Results:
We found 1 in 10 patients with chronic pain were sensitive to the temperature, 1 in 25 to relative humidity, 1 in 50 to pressure, and 3 in 100 to wind speed, after adjusting for age, sex, belief in the weather–pain association, mood, and activity level. The direction of the weather–pain association differed between people. Although participants seem to be differentially sensitive to weather conditions, there is no definite indication that participants' underlying pain conditions play a role in weather sensitivity.

Conclusion:
This study demonstrated that weather sensitivity among patients with chronic pain is more apparent in some subgroups of participants. In addition, among those sensitive to the weather, the direction of the weather–pain association can differ.
Increased Uptake of 18F-PSMA-1007 in Corpus Luteum Demonstrated by PET/CT
Authors: Geysen Astrid , Goffin Karolien , Van Weehaeghe Donatienne , Van Laere Koen , Deroose Christophe M. 
Published: January 2022

Abstract
Two women were referred for an 18F-PSMA-1007 PET/CT in follow-up of an adenoid cystic tumor of the subglottic region and the bronchus, respectively. Only limited tracer uptake was seen in the region of local recurrence and in the region of known metastases. Unexpectedly, an incidental finding consisting of a high tracer uptake at a corpus luteum in the ovary was found in both women.
Renal Extramedullary Hematopoiesis Incidentally Detected on 18F-FDG PET/CT Imaging
Authors: Kaya Gursan , Bozkurt Murat Fani 
Published: January 2022

Abstract

18F-FDG PET/CT imaging of a 68-year-old woman with a known clinical diagnosis of systemic lupus erythematosus and recent-onset ataxia revealed FDG-avid soft tissue masses in bilateral renal sinuses and mildly increased bone marrow activity. Consecutive tissue sampling with fine-needle biopsy from renal sinus masses confirmed mass-forming extramedullary hematopoiesis corresponding to FDG-avid soft tissue lesions. Here we present a rare case of bilateral mass-forming extramedullary hematopoiesis at renal sinuses incidentally detected on 18F-FDG PET/CT imaging.
Increased 68Ga-FAPI Activity in Chondrosarcoma of Nasal Cavity
Authors: Yang Xiao , Ou Lei , Xu Duo , Chen Yue , Liu Huipan 
Published: January 2022

Abstract
Chondrosarcoma is a rare entity tumor, which mainly appears in long bones and pelvic bones, but rarely in nasal cavity. Herein, we report the 68Ga-FAPI PET/CT findings in a 54-year-old man with chondrosarcoma of nasal cavity.
Systemic Immune Response Syndrome After COVID-19 Immunization—Initial and Follow-up 18F-FDG PET/CT Imaging Appearances
Authors: Nawwar Ayah Adel , Searle Julie , Hagan Ian , Lyburn Iain Douglas 
Published: January 2022

Abstract
A 46-year-old woman with previous history of breast cancer had follow-up 18F-FDG PET/CT 5 days after COVID-19 vaccination. In addition to avid axillary nodes, a well-documented feature, the scan demonstrated diffuse splenic and marrow uptake. Clinical history, laboratory, and scan findings were in keeping with SIRS (systemic inflammatory response). The patient recovered with supportive management. On follow-up, 18F-FDG PET/CT imaging 3 months later features had resolved. SIRS after vaccination may be observed on 18F-FDG PET/CT.
Machine Learning Based Non-Enhanced CT Radiomics for the Identification of Orbital Cavernous Venous Malformations: An Innovative Tool
Authors: Han Qinghe , Du Lianze , Mo Yan , Huang Chencui , Yuan Qinghai 
Published: January 2022

Purpose:
To evaluate the capability of non-enhanced computed tomography (CT) images for distinguishing between orbital cavernous venous malformations (OCVM) and non-OCVM, and to identify the optimal model from radiomics-based machine learning (ML) algorithms.

Methods:
A total of 215 cases of OCVM and 120 cases of non- OCVM were retrospectively analyzed in this study. A stratified random sample of 268 patients (80%) was used as the training set (172 OCVM and 96 non-OCVM); the remaining data were used as the testing set. Six feature selection techniques and thirteen ML models were evaluated to construct an optimal classification model.

Results:
There were statistically significant differences between the OCVM and non-OCVM groups in the density and tumor location (P
< 0.05), whereas other indicators were comparable (age, gender, sharp, P > 0.05). Linear regression (area under the curve [AUC] = 0.9351; accuracy = 0.8657) and Stochastic Gradient Descent (AUC = 0.9448; accuracy = 0.8806) classifiers, both of which coupled with the f test and L1-based feature selection method, achieved optimal performance. The support vector machine (AUC = 0.9186; accuracy = 0.8806), Random Forest (AUC = 0.9288; accuracy = 0.8507) and eXtreme Gradient Boosting (AUC = 0.9147; accuracy = 0.8507) classifier combined with f test method showed excellent average performance among our study, respectively.

Conclusions:
The effect of non-enhanced CT images in OCVM not only can help ophthalmologist to find and locate lesion, but also bring great help for the qualitative diagnosis value using radiomic- based ML algorithms.
The role of Memory Clinics in the assessment and management of dementia, now and into the future
Authors: Mehrani Inga , Sachdev Perminder S. 
Published: January 2022

Purpose of review
The diagnosis of dementia is often delayed and many individuals with the disorder go undiagnosed or receive an inadequate assessment. Specialist Memory Clinics have long been at the centre of such assessments. Recent developments in biomarkers and disease-modifying treatments are likely increase the need for specialist assessments. It is therefore timely to review the role of Memory Clinics internationally.

Recent findings
The timely diagnosis of dementia and cognitive decline is the main responsibility of Memory Clinics. These clinics can diagnose dementia up to 4 years earlier than primary care services, but their low numbers and capacity of leads to long waiting times and a focus on complex cases. Few clinics are resourced to offer specific postdiagnostic support services, and their roles in clinical trials and research have not been realised. They are often well integrated with primary care and aged care services.

Summary
Memory Clinics play an important role in bridging the gap between research and clinical practice and providing high-quality assessment and care. Additional Memory Clinic services and greater harmonisation of their responsibilities and procedures are needed to exploit their full potential.
MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas
Authors: Stopfer Lauren E. , Rettko Nicholas J. , Leddy Owen , Mesfin Joshua M. , Brown Eric , Winski Shannon , Bryson Bryan , Wells James A. , White Forest M. 
Published: January 2022

ABSTRACTCombining multiple therapeutic strategies in NRAS/BRAF mutant melanoma – namely MEK/BRAF kinase inhibitors, immune checkpoint inhibitors, and targeted immunotherapies – may offer an improved survival benefit by overcoming limitations associated with any individual therapy. Still, optimal combination, order, and timing of administration remains under investigation. Here, we measure how MEK inhibition (MEKi) alters anti-tumor immunity by utilizing quantitative immunopeptidomics to profile changes in the peptide MHC (pMHC) repertoire. These data reveal a collection of tumor antigens whose presentation levels are selectively augmented following therapy, including several epitopes present at over 1000 copies-per-cell. We leveraged the tunable abundance of MEKi-modulated antigens by targeting 4 epitopes with pMHC-specific T cell engagers and antibody drug conjugates, enhancing cell killing in tumor cells following MEK inhibition. These results highlight drug treatment as a means to enhance immunotherapy efficacy by targeting specific upregulated pMHCs and provide a methodological framework for identifying, quantifying, and therapeutically targeting additional epitopes of interest.SIGNIFICANCEKinase inhibitor treatment in NRAS/BRAF mutant melanoma can sensitize tumors to immunotherapy, in part through an increase in average surface presentation of peptide MHC molecules. Here, we demonstrate that MEK inhibition selectively boosts epitope abundance of select tumor-associated antigens in vitro and in vivo, enhancing targeted immunotherapy efficacy against these treatment-modulated epitopes.