bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on Knowledge of Cardiac Arrest and Its Management Among Health Care Professional Students in Chennai and Kanchipuram
Authors: E Nirman Kanna D. , J Nanthini , R Tamilvanan , Arumugam Sasikumar 
Published: December 2022

Abstract
Background: Cardiac arrest is the most common cause of death worldwide, and early intervention with high quality BLS improves a victim’s chances of survival. A patient in cardiac arrest is treated by early CPR and early defibrillation and administration of Emergency Drugs. Therefore, Every Health Care Professional student should be Knowledgeable about cardiac arrest and its management to save the precious life of patient.
Objective: To assess the Knowledge of Cardiac Arrest and its management among Health Care Professional Students and to educate and create awareness and Knowledge about Cardiac arrest and its management among Heath Care Professional Students
Methodology: A cross sectional study conducted in Chennai and Kanchipuram, from July 9th 2022 to September 9th 2022. Permission was obtained from IEC; a well-organized questionnaire was executed with 23 items using the Google Forms. Pre- structured questions were pre-validated by Experts. Google form contains the details such as socio-demographic, knowledge and its management-based questions. The Completed data was collected, entered in excel sheet and the results was analyzed with the proper statistical method.
Results: According to the statistical analysis of data received, it results, only 4% (21 participants) of health care professional students have good knowledge about cardiac arrest and its management, only 36% (188 participants) of health care professional students have adequate knowledge about cardiac arrest and its management and 60% (316 participants) of health care professional students have inadequate knowledge about cardiac arrest and its management.
Conclusion: This study highly suggests that training programs, simulation-based trainings, seminars and Lecture, etc.… need to be organized to the health care professional students to make them gain knowledge about cardiac arrest and its management to save the precious lives.
A novel risk prediction nomogram to predict 30-day mortality in older patients with sepsis
Authors: Li Fang , Zhou Wei-Feng , Pan Min , Wang Shu 
Published: December 2022

Abstract
Background: Sepsis is a common clinical disease with a high mortality rate, and the prognosis of older patients with sepsis varies. The purpose of this study was to determine the prognostic factors in older patients with sepsis and to establish a prognostic model for predicting short-term mortality in older adults with sepsis, as early intervention is recommended to reduce case fatality rate.
Methods: We reviewed 426 older patients with sepsis and collected their demographic details, clinical information, and data on biological markers for the first time within 24 hours of hospital admission. At the same time, we calculated a Nutrition Risk Screening (NRS-2002) score. In a 7:3 ratio, these patients were randomly divided into a training group (n = 298) and validation group (n = 128). The lasso regression model was used to reduce data dimensions and select features. To construct a prognostic signature, Cox regression analysis was used, based on which a nomogram was developed, and its predictive accuracy was evaluated. The discrimination, calibration, and clinical usefulness of the nomogram were assessed using calibration curves and decision curve analysis (DCA).
Results: Albumin (ALB) level, blood urea nitrogen (BUN) level, lactic acid level, and NRS-2002 score were independent risk factors that affected the 30-day prognosis of older patients with sepsis (P＜0.05). The area under the receiver operating characteristic (ROC) curve (AUC) values of the nomogram of the training and validation groups were 0.772 (95% CI, 0.734-0.812) and 0.730 (95% CI, 0.695–0.766), respectively. The calibration curves fit well in the two groups.
Conclusions: We developed and validated a prognostic nomogram model based on ALB, BUN, and lactic acid levels and NRS-2002 score for older patients with sepsis. This model can help clinicians timely assess the early risk of death in older patients with sepsis and accordingly take proactive measures.
DMA2022 Microscopic mechanism of cyclic hardening/softening of a TRIP-aided duplex stainless steel
Authors: Zou Zongyuan , Song Bibo , Wang Hongzhong , Chen Lei , Jin Miao 
Published: December 2022

Abstract

To further promote high performance transformation-induced plasticity (TRIP) duplex stainless steel’s industrial application in lightweight design of automotive structural parts, the cyclic softening/hardening properties and its microscopic mechanism of a TRIP duplex stainless steel Fe-19.33Cr-1.92Ni-2.7Mn-1.8Si is studied. Symmetrical cyclic loading tests with different strain amplitudes under strain control were conducted. The variation curves of the hysteresis loop and stress amplitude with cycles are obtained, and its cyclic hardening/softening characteristics is analyzed. An experimental study on the microstructure observation of a typical strain amplitude of 1.1% under quasi-in-situ cyclic loading was carried out by Electron Backscattered Diffraction (EBSD) and Transmission Electron Microscope (TEM). The combination of macroscopic mechanical properties and microstructure observation found that the entanglement of dislocations, dislocation interaction and grain boundaries' hindrance to dislocations are the main reasons for the initial cyclic hardening of the test steel. The formation of dislocation walls and dislocation cells leads to subsequent cyclic softening. At the secondary hardening stage, stable low-energy dislocation cells have little effect on the test steel's cyclic hardening/softening properties. The secondary cyclic hardening is mainly dominated by strain-induced ε martensite and α' martensite.
All-inside Arthroscopic Release for Iliotibial Band Syndrome. Description of Surgical Technique and Short-term Results
Authors: Arnal-Burró Juan , Vidal-Fernández Carlos , Igualada-Blázquez Cristina , Cuervas-Mons Manuel , Martínez-Ayora Álvaro , Santos-Vaquinhas Alex Dos 
Published: December 2022

Abstract
Introduction:
Description of an arthroscopic procedure (all-inside arthroscopic release, AIAR) that combines all the possible interventions on the iliotibial band (ITB), and evaluates its outcomes in a group of distance runners diagnosed with ITBS.
Methods
A prospective observational study was made of distance runners diagnosed with ITBS and operated upon using the AIAR technique between 1 January 2018 and 31 June 2020. The surgical technique is described in detail, and the demographic data and functional outcomes measured by the ARS and IKDC sports performance scales are presented.
Results
A total of 14 patients were included, with a mean follow-up of 16 months (range 12–42 months). In all cases, statistically significant improvement was evidenced by the ARS and IKDC scales following AIAR (p = 0.00048), with excellent outcomes in 71% of the cases according to the ARS scale and in 86% according to the IKDC scale (mean difference of 11.9/16 and 33.8/100 points, respectively). No complications were recorded.
Conclusion
The AIAT technique is effective in allowing a return to previous sports performance levels in a short period of time among patients with ITBS refractory to conservative management, with a high satisfaction rate and the absence of complications.
The Effects of Enhanced Formaldehyde Clearance by Applying the NIOSH Hierarchy of Controls in a Gross Anatomy Laboratory
Authors: Durongphan Anuch , Rungruang Jarun , Nitimanee Eakkapong , Pamornpol Benjaporn 
Published: December 2022

Abstract
To date, no learning method substitutes cadaver dissection, but formaldehyde exposure is a significant health concern in the gross anatomy laboratory. Our 2018 study found that most formaldehyde levels in the breathing zone (S-level) and environment (R-level) during laboratory sessions at the Faculty of Medicine of Siriraj Hospital exceed ceiling standards. In this study, we enhanced engineering control of the NIOSH hierarchy of controls by removing the intervening factors of formaldehyde clearance by increasing the area per table and opening the covers of the dissection table, then measuring the ceiling levels by formaldehyde detector tube with a gas-piston hand pump. The analyses excluded the 2018 perineum region data because of the laboratory closure from the COVID-19 outbreak in 2019. There were statistically significant differences between the 2018 and 2019 S-levels (p< 0.001) and R-levels (p<0.001). The mean S-level decreased by 64.18% from 1.34 ± 0.71 ppm to 0.48 ± 0.26 ppm, and the mean R-level decreased by 70.18% from (0.57 ± 0.27 ppm) to (0.17± 0.09 ppm). The trend of the 2019 level is similar to our 2018 study, unlike other published studies showing high formaldehyde levels in the body cavity. The highest formaldehyde level in 2019 was the S-level in the body wall region (1.04 ± 0.3 ppm), followed by the S-level in the abdominal region (0.56 ± 0.08 ppm), and the spinal cord removal region (0.51 ± 0.29 ppm). All 2019 formaldehyde levels passed the OSHA 15 min STEL standard (2 ppm). The R-level in the special sense region (0.06 ± 0.02 ppm) passed the NIOSH 15-min ceiling limit (0.1 ppm). Three 2019 levels were very close: the R-level in the head-neck region (0.11 ± 0.08 ppm), the abdominal region (0.11 ± 0.08), the body wall region (0.14 ± 0.12 ppm), and the S-level in the special sense region (0.12 ± 0.04 ppm). The lower formaldehyde level in 2019 reflects that extensive analysis of individual laboratory formaldehyde clearance defects and correcting them by applying the NIOSH hierarchy of controls is an effective measure.
Deep Evolutionary Forecasting identifies highly-mutated SARS-CoV-2 variants via functional sequence-landscape enumeration
Authors: Colom Mireia Solà , Vucinic Jelena , Adolf-Bryfogle Jared , Bowman James W. , Verel Sébastien , Moczygemba Isabelle , Schiex Thomas , Simoncini David , Bahl Christopher D. 
Published: December 2022

Abstract

Host-pathogen interactions drive an evolutionary game of cat-and-mouse between a pathogen’s protein virulence factors, the host’s adaptive immune system, and therapeutics targeting the pathogen. There is an urgent need for treatments and prophylactics that remain effective as a pathogen evolves, and the ability to predict pathogen evolution is a longstanding challenge. Therefore, a common strategy has been to target conserved epitopes, but strong selective pressures can drive pathogens to evolve resistance nonetheless. Here, we report a novel, generally-applicable approach called Deep Evolutionary Forecasting that predicts protein evolution using artificial intelligence and molecular modeling. The first step is to perform a complete enumeration of the functional sequence landscape in silico for a target protein. Then, we construct a graph where the edges between sequence variants are weighted by evolutionary probability. Protein evolution is forecasted by traversing this graph. We chose the SARS-CoV-2 receptor binding domain (RBD) as a model system because highly-mutated viral variants have continued to emerge that escape available therapeutics and vaccines. The RBD variants that we forecasted carry up to 11 concurrent amino acid substitutions at the host receptor binding site. Pseudoviruses harboring forecasted RBDs are active and escape binding and neutralization by FDA-approved monoclonal antibody therapeutics. We identified bottlenecks in the evolutionary landscape of SARS-CoV-2 that are promising targets for therapeutics that preempt evolution.
Effect of anterior vaginal wall prolapse repair by modified transvaginal mesh surgery: a retrospective cohort study
Authors: HU Pan , LEI Li , WANG Ying , TANG Jing , Liu Lubin 
Published: December 2022

Abstract
Objective To explore clinical outcomes and complications of modified Transvaginal mesh (M-TVM) for advanced anterior vaginal wall prolapse in 1 year follow up.
Methods 574 patients underwent TVM surgeries from 2019 to 2020 were collected and divided into traditional TVM group and M-TVM group according to different surgeries, all preoperative and postoperative data was obtained and compared between the two groups.
Results 285 women were involved eventually, including 181 for TVM group and 104 for M-TVM group. No significant differences of general conditions were found between these two groups. During long-term follow up period, patients in TVM group were more likely to suffer pelvic pain than M-TVM group after surgery (P=0.046). Meshes placed with M-TVM protocol (4.5±0.69 cm) seemed much wider than meshes placed with TVM (3.0±0.91cm). Surgeries can significantly change a prolapse to point Aa and Ba on POP-Q compared to preoperative data. M-TVM procedures may significant change point C and D after surgery compared to TVM surgery(P＜0.001).
Conclusion M-TVM is a commendable procedure that can significant correct anterior prolapse with mesh extended wider, and also supply stable apical support at the same time.
Medieval migrations and the birth of modern British peoples: A craniometric approach
Authors: Valoriani Satu , Irish Joel D. , Megan King , Matteo Borrini 
Published: December 2022

Abstract
Craniometric characteristics can be used to reconstruct among-group variation, potential migration routes and ancestral origins. This study presents the results of the comparison of 946 individuals from 16 British medieval sites using craniometric analyses. The purpose is to determine if: 1) observable craniometric variation among British medieval groups exists, 2) it can be detected from neurocranial or facial measurements, and 3) the potential causes of these differences. Craniometric data were analyzed with multivariate statistical analyses. A selection of 18 variables recorded on each crania was used for comparison among pooled males and females. Principal component analysis was carried out on the mean measurements for each pooled group to detect differences among the samples. The results support previous work by other authors indicating a difference in craniometric measurements among British samples. Male and female samples follow the same discrimination pattern, indicating the validity of the statistical analysis. Both neurocranial and facial measurements contribute to the variability of the groups analyzed. The differences in craniometric measurements are likely determined by the migration of people from other European areas. The samples from the British cities where migration occurred more frequently during and before the Middle Ages (i.e. Hythe, London and Scarborough) confirm this difference. These towns were major ports in medieval times, and the movement of people was frequent, with different nationalities in each area (e.g. Scandinavian, Icelandic, Flemish, French). The hypothesis is further supported by correspondence of the results with historical and archaeological records.
Ground-glass opacity caused by the administration of amikacin liposome inhalation suspension: A case report
Authors: Hashimoto Kazuki , Nii Takuro , Sumitani Hitoshi , Yokoyama Masashi , Hashimoto Naoko , Matsuki Takanori , Tsujino Kazuyuki , Miki Keisuke , Kida Hiroshi 
Published: December 2022

Abstract
Background: Amikacin liposome inhalation suspension (ALIS) is a key drug for the treatment of refractory Mycobacterium avium complex pulmonary disease (MAC-PD), but causes hypersensitivity pneumonitis in rare cases.
Case presentation: A 72-year-old woman was treated with ALIS for refractory MAC-PD. Three weeks later, she was hospitalized for pneumonia. The nose swab PCR test for coronavirus disease 2019, and serum (1,3)-beta-D-glucan test, were negative. Because the opacities worsened after empiric antibiotic therapy, we started corticosteroids, suspecting drug-induced interstitial lung disease (DIILD) caused by ALIS; 3 days later, we found signs of improvement and quickly tapered the corticosteroids. After obtaining informed consent, we performed a drug provocation test of ALIS. Seven days later, she had a re-exacerbation of MAC-ID, leading to a diagnosis of DIILD caused by ALIS.
Conclusions: DIILD caused by ALIS is rare, but should be carefully diagnosed because various opacities appear on chest radiograph during the chronic course of the disease.
GPe Astrocytes and Prototypic Neurons Selectively Represent Routine Formation
Authors: Yang Minsu Abel , Hong Sa-Ik , Kang Shinwoo , Lee Jeyeon , Song Minryung , Lee Sang Wan , Choi Doo-Sup 
Published: December 2022

Abstract
The external globus pallidus (GPe) guides action selection. However, it remains elusive how diverse GPe cells engage in routine formation while learning action sequences in repetitive reward-seeking conditioning. Here, we investigated the Ca2+ signals of GPe cells during routine formation. We found that the dynamics of astrocytes and prototypic neurons’ activities are associated with the refinement of the action sequence, which enables cost-effective reward-seeking.
Adaptive Asymptotic stabilization of Uncertain Nonstrict Feedback Nonlinear HOFA Systems with Time Delays
Authors: Zhao Yuzhuo , Ma Dan , Zhang Yingwei 
Published: December 2022

Abstract
We consider the adaptive control for the nonstrict-feedback uncertain nonlinear high-order fully actuated (HOFA) systems with either uncertain constant delay or time-varying delay. Different from the previous works, the most difficult point is that the uncertain nonlinear function in the HOFA systems contains nonstrict feedback form and time delay in system states. In order to overcome this difficulty, the arbitrary approximation property of the radial basis function neural network (RBF NN) is used to estimate the unknown nonlinear functions. What’s more, the nonstrict-feedback form is transformed into strict-feedback strcture by using the property of Gaussian function. In addition, the appropriate Lyapunov-Krasovskii functions and separation techniques are used to compensate the effect of the unknown constant time delay or time-varying delay. Based on the HOFA system approaches, two adaptive NN controllers are proposed to ensure the system with constant time-delay and time-varying delay to be stabilized asymptotically, respectively. Finally, the proposed control strategies are applied to the thermoacoustic instability systems to demonstrate the feasibility and effectiveness of the obtained results.
New Distributed-TOPSIS Approach for Multi-Criteria Decision-Making Problems in a Big Data Context
Authors: LAMRINI Loubna , ABOUNAIMA Mohammed Chaouki , ALAOUI Mohammed TALIBI 
Published: December 2022

Abstract
Nowadays, the online environment is extra information-rich and allows companies to offer and receive more and more options and opportunities in multiple areas. Thus, decision-makers have abundantly available alternatives to choose from the best one or rank from the most to the least preferred. However, in the multicriteria decision-making field, most tools support a limited number of alternatives with as narrow criteria as possible. Decision-makers are forced to apply a screening or filtering method to reduce the size of the problem, which will slow down the process and eliminate some potential alternatives from the rest of the decision-making process. Implementing MCDM methods in high-performance parallel and distributed computing environments becomes crucial to ensure the scalability of multicriteria decision-making solutions in Big Data contexts, where one can consider a vast number of alternatives, each being described on the basis of a number of criteria.
In this context, we consider TOPSIS one of the most widely used MCDM methods. We present a parallel implementation of TOPSIS based on the MapReduce paradigm. This solution will reduce the response time of the decision-making process and facilitate the analysis of the robustness and sensitivity of the method in a high-dimension problem at a reasonable response time.
Three multicriteria analysis problems were evaluated to show the proposed approach's computational efficiency and performance. All experiments are carried out within GCP's Dataproc, a service allowing the execution of Apache Hadoop and Spark tasks in Google Cloud. The results of the tests obtained are very significant and promising.
Application of Attenuation Coefficient in the Assessment of Hepatic Involvment in Children and Adolescents with Wilson’s disease
Authors: Wang Jiajia , Wang Jinping , Wang Han , Li Boqi , Wang Yixing , Sun Lanting , Wu Xiaoqian 
Published: December 2022

Abstract
Background: To investigate whether the attenuation coefficient (ATT) can be used as a noninvasive index to assess liver involvement in children and adolescents with Wilson’s disease (WD).
Methods: Children and adolescents diagnosed with WD were retrospectively collected from the First Affiliated Hospital of the Anhui University of Traditional Chinese Medicine between May 2022 and August 2022. The findings on ATT, Shear Wave Measurement (SWM), AST to platelet ratio index (APRI), and fibrosis 4 (FIB-4) score were obtained. The liver involvement of WD was classified into 3 groups based on serum levels of collagen type IV (CIV), hyaluronic acid (HA), laminin (LN) and precollagen type III N-terminal peptide (PIIINP): (1) Group1 ( n=25), no abnormalities in CIV, HA, LN and PIIINP; (2) Group2 (n=19), elevation of 1 or 2 indexes in CIV, HA, LN, and PIIINP; Group3 (n=18), elevation of 3 or 4 indicators in CIV, HA, LN, and PIIINP. The levels of ATT, SWM, APRI and FIB-4 were compared between the 3 groups; and correlation of ATT with SWM and triglyceride (TG) was performed using Spearman's correlation analysis. The Receiver operating characteristic (ROC) curve was used to analyze the diagnostic efficacy of ATT alone and its combination with SWM, APRI, and FIB-4 in children and adolescents with WD.
Results: A total of 62 children and adolescents with WD were retrospectively retrieved. ATT levels were significantly different in intergroup comparisons (P <0.001). The ROC curve showed that the area under the curve (AUC) for the diagnosis of hepatic steatosis using ATT was 0.714, 0.712, and 0.867 in Group 1 vs. Group 2, Group 2 vs. Group 3, and Group 1 vs. Group 3, respectively; the sensitivity for the diagnosis of hepatic steatosis in Group 1 vs. Group 2 was 89.47% with the cutoff value of ATT of 0.73 dB/cm/MHz. No significant correlation found between ATT and TG (ρ = 0.154，P = 0.231). Compared to ATT alone, the combination of ATT with APRI and FIB-4 or the combination of ATT with SWM, APRI, and FIB-4 showed a better diagnostic efficacy in Group 1 vs. Group 2 (both P=0.038).
Conclusion: ATT could be used as a non-invasive index for the evaluation of liver steatosis in children and adolescents with WD, with a good clinical applicative value. Furthermore, ATT in combination with APRI, FIB-4, and SWM might have better diagnostic efficacy than ATT alone.