bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Phytase Supplementation on Performance, Metabolic Energy, Ileal Histomorphology, Meat and Bone Mineralization of Broiler Chickens
Authors: Suryani Ade Erma , Anggraeni Ayu Septi , Karimy Mohammad Faiz , Istiqomah Lusty , Herdian Hendra 
Published: May 2022

Abstract
Phytase as a feed additive has been shown to promote broiler performance and bone mineralization. This study evaluated the effects of microbial phytase (produced by L. plantarum A1-E and C. tropicalis TKd-3) on growth performance, metabolic energy, ileal histomorphology, and meat and bone mineralization in broilers. One hundred forty one-day-old broiler chicks were distributed into four treatments, five replicates, and seven chicks in each replicate. The experiment consisted of (FA) basal diet without phytase (negative control); (FB) basal diet with L. plantarum A1-E phytase (500 FTU/kg of feed); (FC) basal diet with C. tropicalis TKd-3 phytase (500 FTU/kg of feed); and (FD) basal diet with commercial phytase (500 FTU/kg of feed, positive control). Results revealed that FB and FC treatments improved the broiler performance index (P < 0.05), and FC treatment tended to increase metabolic energy (P > 0.05). Ileal histomorphology showed that FB treatment increased villus height, villi height to crypt depth ratio, and villus surface area (P < 0.05). Breast meat mineral content of broiler revealed the highest mineral content in FB treatment, mainly of the minerals P, Mg, and Fe (P < 0.05). Moreover, the FC treatment resulted in the highest mineral content in thigh meat, particularly for the minerals Ca, P, Mg, Zn, and Fe (P < 0.05). Tibia bone mineralization showed that FB treatment had the most significant effect (P < 0.05) on the mineral content of P, Mg, and Fe. Conclusively, microbial phytase (L. plantarum A1-E and C. tropicalis TKd-3) increased performance index, whereas L. plantarum A1-E phytase improved villus surface area, increasing the ileum mineral absorption, breast meat mineral content, and tibia mineral deposits.
Ayurveda interventions for Gout: A systematic review
Authors: PS Aswani , Nair Pratibha P , N Sreedeepthi G , Ahemmed Azeem , Rao B.C.S. , Sudhakar D , Srika N 
Published: May 2022

Abstract
BackgroundPatients with Gout frequently use Complementary and Alternative Medicines (CAM therapies), which include Ayurveda medications and treatment procedures, and hence it is essential to determine their safety and efficacy/effectiveness.ObjectivesA systematic review of the published clinical data in view of the safety and efficacy/effectiveness of Ayurvedic treatment protocols in Gout viz-a-viz Vatarakta.MethodsWe searched the PubMed, Cochrane Library (Cochrane Central Register of Controlled Trials: Issue 6 of 12, June 2018), Google Scholar, AYUSH Research Portal (Govt. of India), DHARA, Ancient Science of Life, Shodhganga@INFLIBNET, Online clinical trial registers, and grey literature available from Government Ayurveda College, Trivandrum (Manual search) IPGT & RA, Gujrat Ayurveda University. We excluded abstract-only publications. We could not do a meta-analysis due to the unavailability of relevant studies. Study eligibility criteria: Cases diagnosed as Gout by laboratory findings and/or clinical symptoms, who underwent Ayurvedic treatment/Cases clinically diagnosed as Vatarakta, who underwent Ayurvedic treatment. Participants and interventions and controls: We included participants of either sex satisfying the inclusion criteria who underwent Ayurvedic treatment either Randomized controlled trials (RCTs), Quasi-Experimental Trials, Single group clinical trials, Comparative Clinical Trials (CCTs), and Pragmatic trials.ResultsA total of 398 potentially relevant studies were found, and 21studies met the inclusion criteria, among which ten studies were pre-post studies, seven studies were included among Randomized Comparative Clinical Trials, and four were among Comparative clinical trials.Conclusions and implications of key findingsEven though Ayurveda physicians are pragmatically treating/rehabilitating Vatarakta/Gout cases and reported satisfactory results in terms of both safety and efficacy/effectiveness, this review is unable to produce strong valid evidence to prove the efficacy/effectiveness and safety of Ayurveda over Non-Ayurveda interventions or Placebo due to lack of quality and unavailability of published works. So the authors propose well-organized and methodologically sound quality research works in this regard.Systematic review registration number- PROSPERO (CRD42019131198)
Diurnal, monthly, and seasonal variations of indoor radon concentrations concerning meteorological parameters
Authors: Taşköprü Caner , İcçedef Mutlu , Saç Müslim Murat 
Published: May 2022

Abstract
Indoor radon concentrations and meteorological parameters were measured in an office of the teaching staff at the Institute of Nuclear Sciences, Ege University. Data were collected hourly over 25 months (762 days). Raw data, diurnal, monthly, and seasonal variation of parameters were investigated separately. The results show that the average indoor radon concentration (18 Bq m− 3) is relatively lower than national and international reference values. Indoor radon concentrations showed an increasing and decreasing trend throughout the day. Radon concentrations are slightly higher in the morning (downtime and early hours of the day) and then reduced in the afternoon. This can be related to the daily routine usage of the office, which is affected by ventilation of the room, air temperature variations, etc.
Construction of a predictive model of intravenous calcium supplementation needs following total parathyroidectomy in patients with secondary hyperthyroidism
Authors: Bi Ting , Cheng Guangming , Bai Sijia , Guo Shuai , Feng Xiaodong , Zhang Wei 
Published: May 2022

Abstract
Background Hypocalcemia is a common complication after total parathyroidectomy(t-ptx) in patients with secondary hyperparathyroidism(SHPT), which endangers the lives of patients, but the amount of intravenous calcium supplementation is very different in each patient.Therefore,We aimed to elop a predictive model of intravenous calcium supplementation needs in patients with SHPT after t-ptx.Methods Data for 550 SHPT patients treated in the Department of Hepatobiliary Surgery of the Northern Theater General Hospital were collected from January 2015 - December 2021, with patient biochemical indices being retrospectively evaluated.Results Sex (t=-1.988, p=0.049), serum ferriti (SF) (t=2.155, p=0.033), alkaline phosphatase (AKP) (t=4.501, p=0.000), free thyroxine (FT4) (t=-3.128, p=0.002) were identified as risk factors associated with the need for postoperative intravenous calcium supplementation. The developed predictve model (intravenous calcium supplementation =1235.561-158.547*gender + 0.141*SF + 0.442*AKP - 494.055*FT4; male: 0, female: 1) was effective and passed the F test (F = 22.034, P = 0.000).Conclusions The developed model can be used to reliably predict the amount of intravenous calcium supplementation required by SHPT patients following t-ptx, providing a clinical basis for an evidence-based calcium supplementation scheme.
Categorising Fine-to-Coarse Grained Misinformation: An Empirical Study of the COVID-19 Infodemic
Authors: Jiang Ye , Song Xingyi , Scarton Carolina , Singh Iknoor , Aker Ahmet , Bontcheva Kalina 
Published: May 2022

Abstract
The spread of COVID-19 misinformation on social media has become a major challenge for citizens, with negative real-life consequences. Prior research has focused on detection and/or analysis of COVID-19 misinformation. However, finer-grained classification of misinformation claims has been largely overlooked. The novel contribution of this paper is in introducing a fine-grained annotated misinformation dataset which distinguishes between statements that assert, comment or question on false COVID-19 claims. This new dataset not only enables social behaviour analysis but also enables us to address both an evidence-based and non-evidence-based misinformation classification. Lastly, through a ‘leave claim out’ validation, we demonstrate that classifier performance on unseen COVID-19 misinformation claims is significantly different, as compared to performance on topics present in the training data.
Redox evolution during arc magma differentiation revealed by mineral/melt Fe3+ and Fe2+ partitioning
Authors: Huang Fangfang , Wang Jintuan , Xiong Xiaolin 
Published: May 2022

Abstract
The oxidizing capacity of volcanic gases relies on both the redox state of the mantle and the redox evolution of mantle-derived magmas. Arc magmas transfer abundant volatiles from the mantle and undergo extensive differentiation before degassing. But how the magmatic redox state evolves during differentiation remains enigmatic. The redox evolution of a magma depends on the mineral/melt partition coefficients of Fe3+ and Fe2+ (DFe3+ and DFe2+). However, no systematic DFe3+ and DFe2+ are reported due to the difficulties in analyzing Fe3+ of silicate minerals. Here, we conducted hydrous experiments at 900−1100 °C and 1−2 GPa and determined systematically DFe3+ and DFe2+ using a novel method. With the obtained partition coefficients, we investigated the redox evolution by performing fractional crystallization modelling. The almost invariable redox state during arc magma differentiation implies an oxidizing mantle predated the Great Oxidation Event if it was triggered by the increasing oxidizing capacity of volcanic gases.
Hepatic urea, creatinine and uric acid metabolism in dairy cows with divergent milk urea concentrations
Authors: Prahl Marie C. , Müller Carolin B.M. , Albrecht Dirk , Koch Franziska , Wimmers Klaus , Kuhla Björn 
Published: May 2022

Abstract
Milk urea concentration is an indicator for dietary nitrogen (N)-supply and urinary N-excretion. Dairy cows with high (HMU) compared to low milk urea (LMU) concentration have greater plasma urea, creatinine and uric acid concentrations, but if the liver metabolism accounts for these differences is unknown. Eighteen HMU and 18 LMU cows were fed a diet with a low (LP) or normal (NP) crude protein concentration. An N balance study was performed and a 13C-urea bolus was administered to measure urea pool size. Liver samples were analyzed by 2D-gel-based proteomics and RT-qPCR. Although HMU cows had a greater urea pool, plasma urea, uric acid, and hippuric acid concentrations, these differences were not associated with altered expressions of genes related to urea cycling or N-metabolism. Instead, HMU cows had higher oxidative stress levels. Conclusively, other factors than hepatic urea metabolism account for milk urea concentrations. Despite higher plasma urea concentrations and argininosuccinate synthase 1 protein expression on the LP diet, urea cycle mRNA expressions were not affected, indicating that its activity is not controlled at transcriptional level. Feeding the LP diet resulted in increased expressions of enzymes catabolizing fatty acids, which is presumably due to diminished microbial growth and insufficient energy supply.
Simplified Expansions of Common Latitudes with Geodetic Latitude and Geocentric Latitude as Variables
Authors: LI Xiaoyong , LI Houpu , LIU Guohui , Shaofeng BIAN , Chenchen JIAO 
Published: May 2022

Abstract
Using the symbolic calculation program Mathematica, based on the power series expansions of common latitude with geodetic latitude as a variable, power series expansions of common latitude with geocentric latitude as variable are derived. The coefficients of the two groups of formulas are based on the ellipsoid eccentricity e and the ellipsoid third flattening n, which make the expansions more uniform. Taking CGCS2000 as an example, numerical analysis is applied to verify the accuracy and reliability of the derived power series expansions. By analyzing and calculating the truncation error of common latitude based on ellipsoidal eccentricity e and the third flattening n expansion to different orders, we obtain simplified practical formulas for common latitude that satisfy the requirement of geodesic accuracy. Moreover, we show that the practical formula derived has higher calculation efficiency and easier dissemination, enriches the theory of map projection, and provides a basis for better display of remote sensing images.
The Problems of Patients With Muscular Dystrophy in Accessing Health Services During the COVID-19 Process and Solution Proposals: a Qualitative Research
Authors: TURKEN Askeri , ÇAPAR Haşim , KURT Mehmet Emin , ÇAKMAK Cuma 
Published: May 2022

Abstract
Purpose: It is aimed to reveal the problems experienced by patients with Muscular Dystrophy (MD) in accessing health services during the COVID-19 process and solutions for these problems.Methods: The research is a qualitative study. The participants were reached with the snowball sampling method, and since they were in the pandemic process, the problems they experienced were tried to be revealed by providing access via online methods.Results: Participants are mostly male. Half of the participants are married, and half are single. Participants mostly have a primary education level. Most of the participants do not work. Participants primarily reside in the city center. In addition, nearly half of the participants declared that their income is below 2000TL. Conclusion: In this study, some significant findings of the pandemic regarding MD patients' feelings and thoughts about their life practices, treatments, and access to health services they need for the disease were revealed. Patients with MD stated that they could not easily access the health services they wanted and needed due to muscle weakness. In their opinion, one of the most important reasons for this situation is that the treatments they need are not available in every hospital, or they cannot access them due to their financial and social problems. Another reason pointed out is that the health workers in the family physicians and primary health care institutions they are closest to do not have information about their diseases.
Hematological and ionic parameters in Holstein dairy cows according to the different physiological stage: first report in Algeria
Authors: Mekroud Meriem , Ouchene-Khelifi Nadjet Amina , Titi Amel , ARZOUR-LAKEHAL N. , Ouchene Nassim , Mekroud Abdessalam 
Published: May 2022

Abstract
This study aims to investigate, for the first time in Algeria, the variations of hematological and ionic parameters of Holstein dairy cows according to the physiological stage, as an indicator of its health status. The survey was conducted between January and March 2020 and carried out on 4 lots of 15 dairy cows each. The analysis of blood parameters concerned: red blood cells (RBC), hematocrit (HCT), hemoglobin (HGB), mean corpuscular volume (MCV), mean corpuscular hemoglobin content (MCH), mean corpuscular hemoglobin concentration (MCHC), platelets (PLT), the white blood cells (WBC), lymphocytes (LYM), monocytes (MONO), neutrophils (NEU), eosinophils (EOS), basophils (BASO) and ionic parameters such as potassium (K), chlorine (Cl), calcium (Ca), phosphorus (P) and sodium (Na). The RBC level was lowest in the 2nd third of gestation (6.0 ± 0.8 x 106/µL) and in postpartum period (5.6 ± 0.8 x 106/µL), in comparison to the 1st third (6.6 ± 0.6 x 106 / µL) and 3rd third (dry period) of gestation (6.7 ± 0.5 x 106 / µL) (p<0.0001). The same observation was noted for HCT (p<0.0001). MCV was highest in dry cows (p<0.01). MCH and MCHC were highest in cows that were in the postpartum period (p<0.001). For WBC, the count was higher in the 1st third of gestation compared to the other stages, (11.3 ± 2.2 x 103 / µL) versus (6.4 ± 4.1 x 103 / µL), (5.2 ± 1.3 x 103 / µL), and (8.0 ± 4.9 x 103 / µL) for the 2nd third, 3rd third of gestation, and postpartum, respectively (p<0.001).In postpartum cows, the ionic parameters had the lowest values of potassium (K), calcium (Ca) and phosphorus (P) compared to the other stages (p<0.001).This investigation can be used as a basis for information on the hematological and ionic profile of dairy cattle in order to determine the health status before the onset of clinical signs.
Integrated Analysis of Genes Related to Alzheimer’s Disease Pathogenesis Using Gene Co-expression Networks
Authors: he Xinghong , Zhou Xiuya , Zhang Lifei , Wang Ning , Niu Xiaochen , Zou Chongmin , Li Yang , Wang Li , Wang Xiaohui 
Published: May 2022

Abstract
Background: This study aims to identify key molecular targets in Alzheimer’s disease (AD) occurrence and progression.Methods: GSE5281 was obtained by screening and collection of the GEO database and denoted as set 1. Differential analysis was carried out on AD samples and healthy samples in set 1. Hippocampal tissues which were extracted from APP/PS1 double transgenic mice were used to measure the syntaxin 17 (STX17) gene and protein expression. Set 1 samples was divided into the STX17 high expression group and the low expression group and denoted as set 2. Differential analysis was carried out on set 2. The hippocampal sample expression matrix in GSE48350 was named as set 3 for weighted gene co-expression network analysis (WGCNA). GSE33000 was used to construct the Least absolute shrinkage and selection operator (LASSO) model for analysis and validation. Results: 6151 differentially expressed genes (DEGs) were obtained in set 1. STX17 has significantly low expression in the hippocampal tissues of AD mice. 3651 DEGs were obtained from set 2. 2658 common DEGs were obtained in the overlap of the two sets. 22 co-expression modules were obtained from set 3. 401 genes were ultimately obtained from the overlap between genes in the WGCNA significance module and the common DEGs in the two sets and Cytoscape was used for further visualization analysis to obtain the PPI networks of 18 crucial genes. LASSO model construction and fitting was carried out to obtain seven genes common to AD and STX17 (AMPH, GAD2, GAP43, REPS2, SGIP1, STXBP1, SYN2).Conclusion: Bioinformatics analysis was used to examine the intrinsic mechanisms of AD pathogenesis and determine the important role of STX17 in AD progression. Integrated analysis was used to obtain crucial molecular targets common to AD and STX17, which provides new ideas for future AD mechanistic studies and treatment.
Morbidities associated with Testicular abnormality in pregnancy. A cohort study of 37375 infants
Authors: Lai# Shuhua , Zhang QiuYu , Wu Yi , Xu Ying , Lin Jiajia , Zheng Xinting , Yan Jianying , Lin Hai , Zhang Yulong 
Published: May 2022

Abstract
BACKGROUND
Both hydrocele and cryptorchidism are common congenital abnormalities with an increasing incidence in many countries. Testicular abnormalities such as testicular hydrocele and cryptorchidism and their relationship with maternal hyperglycemia have become current research topics. This study researches whether increased blood sugar levels lead to congenital testicular abnormalities.
MATERIALS & METHODS
This retrospective and consecutive cohort study was conducted on singleton pregnancies having completed 20 or more weeks of gestation from the Fujian Provincial Maternity and Children’s Hospital, China. Differences were assessed with the Pearson χ2 test and the t-test for categorical and continuous variables, respectively. Univariate and multivariate logistic analyses were applied for outcomes.
RESULTS
A total of 37375 infants were enrolled for the selection of cases and controls. We found that oral glucose tolerance test(OGTT) of the case group's glucose level dramatically increased compared with the control group at 1 hour and 2 hours (p = 0.001, p = 0.016). In the testicular hydrocele group a remarkable increase was observed inOGTT1H and OGTT2H with the same criteria compared to the control group (p = 0.0001). Moreover, mothers were diagnosed with gestational diabetes mellitus(GDM) at a higher rate (p = 0.0001). The prevalence of premature delivery was also significantly higher in the testicular hydrocele group than in the control group (p = 0.0001). However, the OGTT0H was significantly higher in the cryptorchidism group compared to the control group (p = 0.0257).
CONCLUSION
The present study showed that hyperglycemia during pregnancy leads to a higher prevalence of testicular abnormality of the infants, such as testicular hydrocele and cryptorchidism. However, further investigation is required to determine whether premature delivery and GDM could contribute to the observed conditions.
Safety and efficacy of low-dose and long-course Tirofiban in large hemispheric infarction
Authors: Hu Yinqin , Xiao Qian , Shi Zhizhen , Hou Yangbo , Chen Zhen , Li Guoyi , Cheng Jiwei 
Published: May 2022

Abstract
Background: The clinical efficacy and safety of tirofiban in the treatment of large hemispheric infarction (LHI) remain controversial.Methods: This study prospectively enrolled patients with acute LHI who were admitted to Putuo Hospital affiliated to Shanghai University of Traditional Chinese Medicine from June 2021 to December 2021. The patients were randomly assigned to the tirofiban group (3-4 µg/(kg·h)) or control group (clopidogrel 75 mg/d). ﻿Results: A total of 71 patients with acute LHI were selected: 36 in tirofiban group and 35 in control group.The reduction of the NIHSS score in tirofiban group was 2.92±9.31 at discharge, and that of the control group was -3.23±12.06 (P=0.021, OR, 0.006; 95% CI, 0.004-0.008). Sixteen patients (16.7%) in tirofiban group and 14 patients (40%) in control group died during hospitalization (P=0.029, OR, 3.333; 95% CI, 1.102-10.088). There was significant difference in mRS 5-6 scores at 90 days between the two groups (P=0.023, OR, 3.055; 95% CI, 1.154-8.088). Howere,there was no difference in mRS 0-1 (P=0.321, OR, 0.5; 95% CI, 0.396-0.632),mRS 2 (P=0.572, OR, 0.579; 95% CI, 0.043-5.777) or mRS 3 (P=0.225, OR, 0.452; 95% CI, 0.123-1.665) scores between the two groups. There was no difference in symptomatic intracranial hemorrhage (P=0.29, OR, 3.281; 95% CI, 0.325-33.169) ,asymptomatic intracranial hemorrhage (P=0.123, OR, 3.517; 95% CI, 0.659-18.782) or systemic bleeding events during hospitalization (P=0.044, OR, 3.235; 95% CI, 1.00-10.469).Conclusions: Low-dose and long-course tirofiban treatment can significantly improve the early neurological function and reduce the in-hospital mortality in LHI patients. It also can improve the quality of life and ability of daily living at 90 days.Meanwhile, tirofiban do not increase the risk of any type of bleeding events.
Single-molecule mid-IR detection through vibrationally-assisted luminescence
Authors: Baumberg Jeremy , Chikkaraddy Rohit , Arul Rakesh , Jakob Lukas 
Published: May 2022

Abstract
Room temperature detection of molecular vibrations in the mid-infrared (MIR, λ=3-30µm) has numerous applications including real-time gas sensing, chemical reactivity, medical imaging, astronomical surveys, and quantum communication [1,2]. However, MIR detection is severely hindered by thermal noise, hence current technologies rely on energy-intensive cooled semiconductor detectors (mercury cadmium telluride, MCT) [3–5]. One way to overcome this challenge is to upconvert the low-energy MIR light into high-energy visible wavelengths (λ=500-800nm) where detection of single photons is easily achieved using silicon technologies [6,7]. This process suffers from weak cross sections and the mismatch between MIR and visible wavelengths, limiting its efficiency. Here, we exploit molecular emitters possessing both MIR and visible transitions from molecular vibrations and electronic states, coupled through Frank–Condon factors. By assembling molecules into a nanoscale cavity and continuously optically pumping them below the electronic absorption band, we show the transduction of MIR light absorbed by the molecular vibrations. The upconverted signal is observed as enhanced high-energy luminescence. Combining Purcell-enhanced visible luminescence with enhanced rates of vibrational pumping gives transduction efficiencies exceeding 10%. By down-scaling the cavity volume below 1nm^3, we show MIR detection of single-molecular bonds, inaccessible to any previous detector.