bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Comparison of Double Poling Physiology and Kinematics Between Long-Distance and All-Round Cross-Country Skiers
Authors: Torvik Per-Øyvind , Sandbakk Øyvind , van den Tillaar Roland , Talsnes Rune Kjøsen , Danielsen Jørgen 
Published: April 2022

PurposeThe objective of this study was to compare physiological and kinematic responses to double poling (DP) between long-distance (LDS) and all-round (ARS) cross-country skiers.MethodsA number of five world-class LDS (28.8 ± 5.1 years, maximal oxygen uptake (VO2max): 70.4 ± 2.9 ml·kg−1·min−1) and seven ARS (22.3 ± 2.8 years, VO2max: 69.1 ± 4.2 ml·kg−1·min−1) athletes having similar training volumes and VO2max performed three identical tests; (1) submaximal and incremental tests to exhaustion while treadmill DP to determine gross efficiency (GE), peak oxygen uptake (DP-VO2peak), and peak speed; (2) submaximal and incremental running tests to exhaustion to determine GE, VO2max (RUN-VO2max), and peak speed; and (3) an upper-body pull-down exercise to determine one repetition maximum (1RM) and peak power. Physiological responses were determined during both DP and running, together with the assessments of kinematic responses and electromyography (EMG) of selected muscles during DP.ResultsCompared to ARS, LDS reached higher peak speed (22.1 ± 1.0 vs. 20.7 ± 0.9 km·h−1, p = 0.030), DP-VO2peak (68.3 ± 2.1 vs. 65.1 ± 2.7 ml·kg−1·min−1, p = 0.050), and DP-VO2peak/RUN-VO2max ratio (97 vs. 94%, p = 0.075) during incremental DP to exhaustion, as well as higher GE (17.2 vs. 15.9%, p = 0.029) during submaximal DP. There were no significant differences in cycle length or cycle rate between the groups during submaximal DP, although LDS displayed longer relative poling times (~2.4% points) at most speeds compared to ARS (p = 0.015). However, group × speed interaction effects (p &lt; 0.05) were found for pole angle and vertical fluctuation of body center of mass, with LDS maintaining a more upright body position and more vertical pole angles at touchdown and lift-off at faster speeds. ARS displayed slightly higher normalized EMG amplitude than LDS in the muscles rectus abdominis (p = 0.074) and biceps femoris (p = 0.027). LDS performed slightly better on 1RM upper-body strength (122 vs. 114 kg, p = 0.198), with no group differences in power in the pull-down exercise.ConclusionsThe combination of better DP-specific aerobic energy delivery capacity, efficiency, and technical solutions seems to contribute to the superior DP performance found among specialized LDS in comparison with ARS.
Changes in Thromboelastography to Predict Ecchymosis After Knee Arthroplasty: A Promising Guide for the Use of Anticoagulants
Authors: Chen Yuelong , Qin Leilei , Yang Jianye , Wang Jiawei , Huang Jiaxing , Gong Xuan , Hu Ning 
Published: April 2022

BackgroundEcchymosis is one of the worrisome complications after total knee arthroplasty (TKA) and interferes with functional rehabilitation. Current clinical guidelines do not provide individualized approaches for patients with ecchymoses.MethodsIn this study, we used thromboelastography (TEG) to determine the coagulation state after TKA and to then explore markers that predict the occurrence of ecchymosis events after TKA. In our cohort, patients were divided into ecchymosis (n = 55) and non-ecchymosis (n = 137) groups according to whether ecchymosis events occurred after TKA. Rivaroxaban 10 mg/d was taken orally for thromboprophylaxis after surgery. All patients completed TEG testing. Correlation analysis was used to determine the risk factors for ecchymosis after TKA, and receiver operating characteristic (ROC) curves for variables with significant correlation were plotted.ResultsIn all, 55 of the 192 patients (28.65%) developed ecchymosis surrounding the surgical site. Multivariate analysis showed that hidden blood loss (OR = 1.003 and p = 0.005) and changes in the coagulation index (ΔCI) values (OR = 0.351 and p = 0.001) were risk factors for ecchymosis after TKA. Using the Youden index, 0.1805 was determined as the optimal threshold value of ΔCI for predicting the occurrence of ecchymosis, with a sensitivity of 74.55% and specificity of 72.99%. ΔCI is a promising marker as an alarm for the occurrence of ecchymosis after TKA.Trial RegistrationThe study was registered in the Chinese Clinical Trial Registry (ChiCTR1800017245). Registered name: The role of thrombelastography in monitoring the changes of coagulation function during perioperative period of arthroplasty. Registered 19 July 2018. http://www.chictr.org.cn/showproj.aspx?proj=29220
Polyostotic Fibrous Dysplasia Complicated by Pathological Fracture of Right Femoral Shaft with Nonunion: A Case Report
Authors: Yang Qifan , Liu Jing , Tan Lei , Jiang Ye , Zhu Dong 
Published: April 2022

IntroductionFibrous dysplasia is a benign fibrous bone tumor that accounts for 5% to 10% of benign bone tumors. It can manifest as simple fibrous dysplasia (70%–80%), polyostotic fibrous dysplasia (20%–30%), with approximately the same incidence in men and women. We report a patient with a rare case of multiple fibrous dysplasia combined with proximal femoral shepherd deformity with pathological fracture of the femoral shaft complicated by nonunion. It is necessary to understand the disease in more detail to avoid overtreatment of benign lesions or misdiagnosis of malignant tumors and other diseases.Case presentationA 58-year-old man with polyostotic fibrous dysplasia, bilateral proximal femur deformity, Shepherd’s angle deformity, right femoral shaft pathological fracture complicated by nonunion, we under fluoroscopy, in the obvious proximal fracture, take osteotomy, and process the shape of the cut bone fragment to adapt it to the corrected force line, and then restore it back to its original position, using intramedullary nailing technology complete the operation. Three months after the operation, he came to the hospital for re-examination, and an X-ray of the right femur was taken. It was found that the fractured end had a tendency to heal. The patient was instructed to gradually bear weight. After six months of re-examination, the patient could walk with a walker. One year after the operation, the patient could walk without a walker and take care of himself at home. However, there was still stretch-like pain in the right lower back, but it was tolerable.ConclusionsFor patients with polyostotic fibrous dysplasia combined with proximal femoral shepherd deformity and pathological fracture of the femoral shaft with nonunion, osteotomy combined with intramedullary nailing is a simple and convenient way to correct the deformity and obtain correct fracture alignment.
The Effect of Anlotinib Combined with anti-PD-1 in the Treatment of Gastric Cancer
Authors: Zheng Wubin , Sun Guoqiang , Li Zhitao , Wu Fan , Sun Guangshun , Cao Hongyong , Zhou Jin , Ma Yong 
Published: April 2022

BackgroundProtein tyrosine kinase (PTK) signaling pathway has been confirmed to be involved in the proliferation, differentiation and migration of tumor cells. Anlotinib, as a multi-target tyrosine kinase inhibitor, which can inhibit the expression of vascular endothelial growth factor receptor (VEGFR), has been confirmed to have significant therapeutic effects on non-small cell lung cancer, medullary thyroid carcinoma, and soft tissue sarcoma, but the therapeutic effect on gastric cancer (GC) is still unclear.MethodsAnlotinib was screened out of 880 drugs through Cell Counting Kit 8 (CCK-8) technology. TCGA was used to detect the expression of VEGFR in GC, and Kaplan-Meier Plotter was used to analyze the correlation between the expression of VEGFR and the survival rate of GC patients. The impacts exerted by anlotinib to GC cell proliferating, migrating and invading processes were assessed through wound healing assay, transwell assay, and proliferation assay in vitro. In vivo experiments of GC were performed in C57/B6 mouse model to evaluate the function of anlotinib and PD-1 antibody.ResultsIt was found from more than compunds that anlotinib has a significant inhibitory effect on GC cells. In vitro experiments show that anlotinib can significantly inhibit the proliferation, invasion and proliferation of GC cells. The expression level of VEGFR is related to the prognosis and survival of GC. GC patients with low expression of VEGFR have better survival. Anlotinib can inhibit the expression of PD-L1, and achieve better therapeutic effects after combined with PD-1 antibody.ConclusionThe present study reveals that anlotinib down regulates PD-L1. The combination of anlotinib and PD-1 monoclonal antibody is beneficial to GC therapy.
Spatial Distribution and Determinant Factors of Handwashing Practice With Essential Agents Among Households in Ethiopia
Authors: Kebede Sewnet Adem , Tusa Biruk Shalmeno , Weldesenbet Adisu Birhanu 
Published: April 2022

Objectives: This study aimed to assess the spatial distribution and determinant factors of handwashing practice using essential handwashing agents (soap and water) among households in Ethiopia.Methods: A two-stage stratified cluster sampling technique was used. Mixed-effect logistic regression analysis was also used to identify determinants of handwashing practice with essential agents.Results: In Ethiopia, household handwashing practices with essential agents had spatial variation (Moran’s Index 0.62, p &lt; 0.001). The Amhara and Somali regions were identified as significant hotspots with low handwashing practice using essential agents.Conclusion: In Ethiopia, handwashing practice with essential agents showed spatial variation across the country with a very low rate. Areas with low handwashing practice with essential agents need high priority in the allocation of resources to ensure communities’ access to fixed and portable handwashing facilities, soap, and reliable water supplies. Households with low access to improved sanitation facilities, low wealth status, and low educational status should be targeted for the intervention.
Lichenoid Reaction vs Psychogenic Pruritus
Authors: Заславский Д.В. , Трещевская А.А. , Соболев А.В. , Скрек С.В. , Сыдиков А.А. , Зелянина М.И. , Заславская О.Л. , Машука Д.М. , Васильев Н.Ю. , Емец Э.Д. , Юновидова А.А. 
Published: April 2022

В статье описаны ключевые звенья патогенеза медикаментозной лихеноидной реакции, а также отражена современная концепция межклеточного взаимодействия с развитием аутоиммунного воспаления в коже. Определена роль лекарственных препаратов в патогенезе развития лихеноидной реакции, указаны наиболее типичные молекулы, вызывающие парадоксальные реакции макроорганизма, объяснена роль полипрагмазии.Очевидным фактом, вытекающим из повествования статьи, является необходимость и значимость проведения соматического, психоневрологического, дерматоскопического и патоморфологического исследований у пациентов с кожным зудом. Приведен случай собственного клинического наблюдения у пациентки, длительно страдающей тяжелой формой лихеноидной реакции, которая впоследствии сформировала целый симптомокомплекс генерализованного тревожного расстройства, способствовала возникновению суицидальных мыслей и, как следствие, привела к госпитализации пациентки в психиатрическую больницу. Особое внимание уделяется описанию клинических проявлений лихеноидной реакции и дифференциальной диагностике с другими дерматозами.
The article describes the key links in pathogenesis of drug lichenoid reaction, and also reflects the modern concept of cell-cell interaction with the development of autoimmune inflammation in the skin. The role of drugs in the pathogenesis of lichenoid reaction is determined, the most typical molecules causing paradoxical reactions of the macroorganism are indicated and the roleof polypharmacy is explained. The obvious fact arising from the story of the article is the need and significance of conducting somatic, psychoneurological, dermatoscopic, and pathomorphological studies in patients with itchy skin. We report a case in a young patient who was suffering from a severe form of lichenoid reaction for a long time, which subsequently formed a whole complex of psycho-emotional disorders, contributed to the emergence of suicidal ideas and, as a result, led the patient to hospitalization in the psychiatric ward. Particular attention is paid to the description of the clinical manifestations of lichenoid reaction and differential diagnosis with other dermatoses.
Aggression of People with schizophrenia: a study of the interaction of symptoms, Cognitive Functions, and environmental Factors. Literature Review
Authors: Хмара Н.В. , Скугаревский О.А. 
Published: April 2022

Приведенный литературный обзор направлен на поиск новых коррелятов агрессии при шизофрении. Описаны разные виды агрессивного поведения и предпочтительность проявления этих форм лицами с шизофренией. Рассмотрены социальные представления, а также их влияние на проявление насилия этой группой населения. Проведен дополнительный анализ одного из внешних провокаторов агрессии – алкоголя. Изучена роль как отдельных симптомов (исполнительских когниций, продуктивной и негативной симптоматики) в проявлении враждебности, так и их взаимодействия. Сделана попытка установить влияние алкоголя на психопатологические симптомы и исполнительские функции у лиц, страдающих шизофренией с агрессивными тенденциями. Выявлена недостаточная изученность влияния доклинических форм употребления алкоголя на течение заболевания, формирование и проявления враждебности. Необходимы дальнейшие исследования для подтверждения и расширенного понимания данных выводов.
The literature review is aimed at finding new correlates of aggression in schizophrenia. Different types of aggressive behavior and the preference of manifestation of these forms by people with schizophrenia are described. the social views, as well as their impact on the manifestation of violence by this group of population, are examined. there was conducted the additional analysis of one of the external provocateurs of aggression – alcohol. the role of individual symptoms (performance cognition, productive and negative symptoms) on the manifestation of hostility was studied, and their interaction was also examined. an attempt was made to reveal the effect of alcohol on psychopathological symptoms and executive functions in people with schizophreniawith aggressive tendencies. Inadequate knowledge of the influence of preclinical forms of alcohol consumption on the course of the disease, formation and manifestation of hostility was revealed. Further research is needed to confirm and broaden our understanding of these findings.
Psychotherapeutic and psychoprophylactic help to somatic patients who use psychoactive substances in the family medicine practice
Authors: Табачников С.И. , Мишиев В.Д. , Харченко Е.Н. , Осуховская Е.С. , Гриневич Е.Г. , Васильева А.Ю. , Чепурная А.Н. , Салдень В.И. 
Published: April 2022

В статье изложена система психотерапии и психопрофилактики в комплексном лечении лиц, употребляющих психоактивные вещества и имеющих соматические последствия, в практике семейной медицины.
In the article, there is described the system of psychotherapy and psychoprophylaxis in the complex treatment of persons, who use psychoactive substances and have somatic consequences in the family medicine practice.
Trends of Donation of Blood and Blood Components in the Republic of Belarus
Authors: Карпенко Ф.Н. , Старовойтов А.Г. , Барц В.А. , Красько О.В. , Расюк Е.Д. , Пасюков В.В. 
Published: April 2022

В Республике Беларусь с 2013 г. организована система донорства крови за плату и на безвозмездной основе. За период 2013–2018 гг. представлены результаты определения динамических трендов донорства крови и ее компонентов, включая изменения общего числа доноров крови и ее компонентов, количества первичных доноров крови, безвозмездных донаций крови в целом и по регионам и взаимное влияние данных показателей. Установлено среднегодовое увеличение числа доноров крови и ее компонентов на 3,8%, числа первичных доноров крови на 7,16%, количества безвозмездных донаций крови на 4,5%. При тесте на параллельность выявлены зависимость трендов увеличения доноров и первичных доноров (p>0,05) и большее увеличение числа безвозмездных донаций по сравнению с увеличением числа доноров и безвозмездных доноров (p<0,05). Сделан вывод о необходимости дальнейшего изменения национального законодательства и развития программ добровольного без возмездного регулярного донорства, что должно привести к увеличению общего числа доноров и количества первичных доноров.
Since 2013 in the Republic of Belarus, the blood donation system has been organized for a fee and free of charge. For the period from 2013 to 2018, there are presented the results of determination of dynamic trends of the national blood donation system, including changes of the number of blood donors and its components, the number of first-time blood donors, non-remunerated blood donation in all regions, and the influence of these indicators. It was revealed that theaverage annual number of blood donors and its components increased by 3.8%, the number of primary blood donors – by 7.16%, the number of free blood donations – by 4.5%. The parallelism test revealed the dependence of trends of increase of donors and first-time donors (p>0.05) and a larger increase of the number of free donations, if compared to increase of the number of donors and free donors (p<0.05). There was made the conclusion about the need for further changes in the national blood service program and the development of voluntary non-remunerated donation programs that should lead to the increase of the total number of donors and the number of first- time donors.
Diagnostic Aspects and Intensive Care of Patients with Sepsis-Associated DIC Syndrome
Authors: Зуховицкая Е.В. , Якубцевич Р.Э. 
Published: April 2022

Актуальной проблемой является ведение в отделении реанимации и интенсивной терапии пациентов с сепсисом, особенно когда сепсис осложняется ДВС-синдромом. В статье рассматриваются вопросы патогенеза ДВС-синдрома, ассоциированного с сепсисом, а также аспекты диагностики и оптимальной тактики при данной патологии. Активация коагуляции при сепсисе обусловливает формирование ДВС, проявляющегося распространенным микрососудистым тромбозом в сосудах малого и среднего калибра и кровотечениями. Частота ДВС при сепсисе и септическом шоке различается и составляет около 40,7% в исследовании KyberSept и 22,4% в исследовании PROWESS. Наиболее чувствительным маркером является тромбоцитопения, в первую очередь потому, что ПВ и АЧТВ могут быть нормальными. Тромбоцитопения, сохраняющаяся на 14-й день от начала пребывания в ОРИТ у пациентов с сепсисом, ассоциировалась с 66%-ной летальностью, по сравнению с 12%-ной летальностью у пациентов с сепсисом без тромбоцитопении. Интенсивная терапия пациентов с септической коагулопатией включает не только инфузию низкомолекулярного гепарина, но и введение концентрата АТ III и плазмаферез.
An urgent problem is the management of patients with sepsis in the intensive care unit, especially when sepsis is complicated by disseminated intravascular coagulation (DIC). The article discusses the pathogenesis of DIC syndrome associated with sepsis, as well as aspects of diagnosis and optimal tactics in this pathology. Activation of coagulation in sepsis causes the formation of DIC, manifested by widespread microvascular thrombosis in small and medium-sized vessels and bleeding. The incidence of DIC for sepsis and septic shock hovers around 40.7% in the KyberSept trial and 22.4% in the PROWESS study. The most sensitive marker is thrombocytopenia, primarily because PT and APTT may be normal. Thrombocytopenia persisting on day 14 from the beginning of ICU stay in patients with sepsis was associated with 66% mortality, compared with 12% mortality in patients with sepsis without thrombocytopenia. Intensive therapy for patients with septic coagulopathy includes not only infusion of low molecular weight heparin, but also the administration of AT III concentrate and plasma exchange.
Pengendalian Internal, Ketaatan Aturan Akuntansi Terhadap Kecenderungan Kecurangan Akuntansi (Fraud) Dengan Perilaku Tidak Etis
Authors: Putri Rizka Rahmania 
Published: April 2022

Di dalam akuntansi memiliki aturan yang harus dipatuhi, karena di dalam akuntansi ada peraturan yang harus diterapkan dan dipatuhi dengan baik oleh semua orang. Perilaku tidak etis tersebut dapat berakibat munculnya kecurangan dalam melaksanakan aturan akuntansi. Penelitian ini bertujuan untuk menguji pengaruh pengendalian internal, ketaatan aturan akuntansi terhadap kecenderungan kecurangan akuntansi (fraud) dengan perilaku tidak etis sebagai variabel intervening pada badan Keuangan kota bukittinggi. Penelitian ini menggunakan data primer yang diperoleh dengan memberikan kuesioner secara langsung kepada responden Pegawai badan keuangan kota bukittinggi. Analisis data dalam penelitian ini menggunakan uji validitas, uji reliabilitas, uji asumsi klasik (uji normalitas data. Uji multikolinieritas, dan uji heteroskedastisitas), analisis regresi liniar berganda. Koefisien determinan (r²), koefisien regresi secara parsial (uji t), koefisien regresi. Secara bersama-sama (uji f) dan analisis jalur. Adapun keseluruhan analisis data. Menggunakan software spss statistic 25. Hasil penelitian ini menyimpulkan bahwa terdapat pengaruh positif dan signifikan pengendalian internal terhadap kecenderungan kecurangan Akuntansi (fraud), terdapat pengaruh positif dan signifikan ketaatan aturan akuntansi terhadap kecenderungan kecurangan akuntansi (fraud), terdapat pengaruh positif dan signifikan Pengendalian Internal terhadap perilaku tidak etis, terapat pengaruh negatif dan signifikan ketaatan aturan akuntansi terhadap perilaku tidak etis,terdapat pengaruh positif dan signifikan perilaku tidak etis terhadap kecenderungan kecurangan akuntansi (fraud), pengaruh pengendalian internal terhadap kecenderungan kecurangan akuntansi (fraud), dengan perilaku tidak etis yang terjadi di dalam akuntansi untuk membatasi munculnya kecurangan di dalamnya.Kata kunci: Kata kunci dituliskan dalam 5 kata yang merupakan subset dari judul makalah, ditulis dengan menggunakan huruf kecil kecuali untuk singkatan, dan dipisahkan dengan tanda baca koma untuk antar kata.