bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous Glucose Monitoring–Guided Insulin Administration in Hospitalized Patients With Diabetes: A Randomized Clinical Trial
Authors: Spanakis Elias K. , Urrutia Agustina , Galindo Rodolfo J. , Vellanki Priyathama , Migdal Alexandra L. , Davis Georgia , Fayfman Maya , Idrees Thaer , Pasquel Francisco J. , Coronado Walkiria Zamudio , Albury Bonnie , Moreno Emmenlin , Singh Lakshmi G. , Marcano Isabel , Lizama Sergio , Gothong Chikara , Munir Kashif , Chesney Catalina , Maguire Rebecca , Scott William H. , Perez-Guzman M. Citlalli , Cardona Saumeth , Peng Limin , Umpierrez Guillermo E. 
Published: August 2022

OBJECTIVE
The efficacy and safety of continuous glucose monitoring (CGM) in adjusting inpatient insulin therapy have not been evaluated.

RESEARCH DESIGN AND METHODS
This randomized trial included 185 general medicine and surgery patients with type 1 and type 2 diabetes treated with a basal-bolus insulin regimen. All subjects underwent point-of-care (POC) capillary glucose testing before meals and bedtime. Patients in the standard of care (POC group) wore a blinded Dexcom G6 CGM with insulin dose adjusted based on POC results, while in the CGM group, insulin adjustment was based on daily CGM profile. Primary end points were differences in time in range (TIR; 70–180 mg/dL) and hypoglycemia (&lt;70 mg/dL and &lt;54 mg/dL).

RESULTS
There were no significant differences in TIR (54.51% ± 27.72 vs. 48.64% ± 24.25; P = 0.14), mean daily glucose (183.2 ± 40 vs. 186.8 ± 39 mg/dL; P = 0.36), or percent of patients with CGM values &lt;70 mg/dL (36% vs. 39%; P = 0.68) or &lt;54 mg/dL (14 vs. 24%; P = 0.12) between the CGM-guided and POC groups. Among patients with one or more hypoglycemic events, compared with POC, the CGM group experienced a significant reduction in hypoglycemia reoccurrence (1.80 ± 1.54 vs. 2.94 ± 2.76 events/patient; P = 0.03), lower percentage of time below range &lt;70 mg/dL (1.89% ± 3.27 vs. 5.47% ± 8.49; P = 0.02), and lower incidence rate ratio &lt;70 mg/dL (0.53 [95% CI 0.31–0.92]) and &lt;54 mg/dL (0.37 [95% CI 0.17–0.83]).

CONCLUSIONS
The inpatient use of real-time Dexcom G6 CGM is safe and effective in guiding insulin therapy, resulting in a similar improvement in glycemic control and a significant reduction of recurrent hypoglycemic events compared with POC-guided insulin adjustment.
Associations of New-Onset Atrial Fibrillation With Risks of Cardiovascular Disease, Chronic Kidney Disease, and Mortality Among Patients With Type 2 Diabetes
Authors: Geng Tingting , Wang Yi , Lu Qi , Zhang Yan-Bo , Chen Jun-Xiang , Zhou Yan-Feng , Wan Zhenzhen , Guo Kunquan , Yang Kun , Liu Liegang , Liu Gang , Pan An 
Published: August 2022

OBJECTIVE
Atrial fibrillation (AF) frequently occurs in patients with type 2 diabetes (T2D); however, the longitudinal associations of new-onset AF with risks of adverse health outcomes in patients with T2D remain unclear. In this study, we aimed to determine the associations of new-onset AF with subsequent risks of atherosclerotic cardiovascular disease (ASCVD), heart failure, chronic kidney disease (CKD), and mortality among patients with T2D.

RESEARCH DESIGN AND METHODS
We included 16,551 adults with T2D, who were free of cardiovascular disease (CVD) and CKD at recruitment from the UK Biobank study. Time-varying Cox regression models were used to assess the associations of incident AF with subsequent risks of incident ASCVD, heart failure, CKD, and mortality.

RESULTS
Among the patients with T2D, 1,394 developed AF and 15,157 remained free of AF during the follow-up. Over median follow-up of 10.7–11.0 years, we documented 2,872 cases of ASCVD, 852 heart failure, and 1,548 CKD and 1,776 total death (409 CVD deaths). Among patients with T2D, those with incident AF had higher risk of ASCVD (hazard ratio [HR] 1.85; 95% CI 1.59–2.16), heart failure (HR 4.40; 95% CI 3.67–5.28), CKD (HR 1.68; 95% CI 1.41–2.01), all-cause mortality (HR 2.91; 95% CI 2.53–3.34), and CVD mortality (HR 3.75; 95% CI 2.93–4.80) compared with those without incident AF.

CONCLUSIONS
Patients with T2D who developed AF had significantly increased risks of developing subsequent adverse cardiovascular events, CKD, and mortality. Our data underscore the importance of strategies of AF prevention to reduce macro- and microvascular complications in patients with T2D.
Initiation of New Glucose-Lowering Therapies May Act to Reduce Physical Activity Levels: Pooled Analysis From Three Randomized Trials
Authors: Yates Thomas , Sargeant Jack A. , King James A. , Henson Joe , Edwardson Charlotte L. , Redman Emma , Gulsin Gaurav S. , Brady Emer M. , Ahmad Ehtasham , Stensel David J. , Webb David R. , McCann Gerry P. , Khunti Kamlesh , Davies Melanie J. 
Published: August 2022

OBJECTIVE
Sodium–glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists (GLP-1RA) reduce body weight and improve cardiometabolic health, but their effect on physical activity is unknown.

RESEARCH DESIGN AND METHODS
We pooled data (n = 148) from three randomized trials to investigate the effect of empagliflozin (SGLT2i) and liraglutide (GLP-1RA), in comparison with sitagliptin (dipeptidyl peptidase 4 inhibitor) and dietary therapies, on accelerometer-assessed physical activity.

RESULTS
Liraglutide (mean −1,144 steps/day; 95% CI −2,069 to −220), empagliflozin (−1,132 steps/day; −1,739, −524), and sitagliptin (−852 steps/day; −1,625, −78) resulted in reduced total daily physical activity after 6 months (P &lt; 0.01 vs. control). Moderate- to vigorous-intensity physical activity was also reduced. Dietary interventions led to no change or an increase in physical activity.

CONCLUSIONS
The initiation of all glucose-lowering therapies was associated with reduced physical activity, warranting further investigation.
Adjusted Cut-Off Scores Increase Sensitivity of Depression Screening Measures in Adolescents with Type 1 Diabetes
Authors: Marker Arwen M. , Patton Susana R. , Clements Mark A. , Egan Anna E. , McDonough Ryan J. 
Published: August 2022

<p> </p>
<p>Objective: To measure the acceptability and diagnostic accuracy of commonly used depression screening measures to determine ideal cut-off scores that sensitively identify depressive disorders in adolescents with type 1 diabetes (T1D). </p>
<p>Research Design and Methods: One hundred adolescents (12-17 year-olds) completed a reference standard, semi-structured diagnostic interview and both long and short versions of five commonly used depression screening measures in the United States. To assess feasibility and acceptability, we used screener completion time and participant ratings, respectively. We used descriptive statistics, area under the receiver operating characteristic (ROC) curve analyses and paired-sample area differences under the ROC curve to assess each measure’s diagnostic validity against our reference standard and to determine ideal cut-off scores for this sample. </p>
<p>Results: Adolescents had a mean age of 15.0±1.7 years, time since T1D diagnosis of 6.0±4.1 years, and glycated hemoglobin (HbA1c) of 8.9±1.8%. Sixty percent of adolescents were male, 15% endorsed a current depressive disorder, and 15% endorsed lifetime suicidality. Measures demonstrated low sensitivity (.33-.67) to detect current depressive disorders using pre-existing cut-off scores. However, adjusted cut-off scores increased sensitivity and reduced false negatives. All depression screening measures demonstrated “good” to “excellent” predictive validity, and the Children’s Depression Inventory-2 Short version (CDI-2 Short) demonstrated significantly greater diagnostic accuracy than the Patient Health Questionnare-2 item version for adolescents (PHQ-2A). </p>
<p>Conclusions: Clinics should consider using screening measures with the greatest diagnostic accuracy as identified in this study and adjusting measure cut-off scores to increase sensitivity and reduce false negatives. </p>
Strategi Pembelajaran Sekolah Indonesia Kuala Lumpur (SIKL) di Era New Normal
Authors: Partono Partono , Fitriyani Uun , Alawiyah Robbiatul , Maghfiroh Alfi Izza , Darojah Innarotut 
Published: August 2022

Penelitian ini memaparkan tentang strategi pembelajaran SIKL yang di hadirkan dampak adanya pandemi Covid-19. Proses pengumpulan data dalam penelitian ini menggunakan metode kualitatif untuk mengetahui proses dan stategi pembelajaran di SIKL. Hasil dari penelitian menunjukkan terdapat pembagian kategori siswa seperti “high risk” dan “low risk, lalu penggunaan aplikasi RPP digital yang lebih fokus dan berorientasi pada kompetensi peserta didik, selain itu menerapkan protokol kesehatan yang mengharuskan para guru dan staf kebersihan sekolah menyiapkan sekolah agar sesuai dengan aturan New Normal seperti wajib memakai masker, melakukan cek suhu badan, menata ruang, social distancing, dan pengaturan satu kelas hanya dapat menampung 15 siswa. Kelas juga dilengkapi dengan handsanitizer. Sebagai sekolah yang berintegritas, SIKL memiliki beberapa strategi inovasi dan treatment yang harapannya bisa memberi pengaruh positif kepada siswa yakni meliputi fokus metode mengajar, kurikulum, relasi antar guru dan siswa, dan disiplin sekolah.
An Assessment of Environmental Risk of Bt-Maize on Rove Beetle Communities
Authors: Twardowski Jacek Piotr , Gruss Iwona , Bereś Paweł , Hurej Michał , Klukowski Zdzisław 
Published: August 2022

Abstract
An environmental risk assessment related to the genetically modified crops still needs to be studied. In the non-target organisms, rove beetles seem to be well-chosen arthropods for this purpose. Rove beetle abundance and species diversity were studied in the first large-scale Bt-maize experiment in the south part of Poland for over two years to determine the impact of Bt-maize in comparison to conventional varieties. A genetically engineered Bt-maize variety (DKC 3421 Yield Gard®, event MON 810) and its near-isogenic DKC 3420 were cultivated at two locations. Additionally, two non-Bt varieties sprayed with a lambda-cyhalothrin insecticide were also included for comparative analysis. The results show no significant effects on rove beetle abundance and diversity patterns of the Bt-maize and the nearby isolines. In one locality the mean number of individuals and Simpson dominance was even higher in Bt-maize compared to one reference variety. The Canonical Correspondence Analysis showed rather variety-dependent effects of the rove beetle community. To conclude, considering the abundance and diversity of studied insects, there is no environmental risk arising from Bt-maize cultivation.
O clampeamento imediato ou tardio na redução da mortalidade perinatal: uma revisão de literatura
Authors: Baptista Vanessa da Silva , Ribeiro Letícia Campitelle Perri , Felippe Rodrigo Maia Santos , Oliveira Carla Resende Vaz , Reis Bruno Cezario Costa 
Published: August 2022

Objetivo: Examinar os potenciais efeitos do clampeamento tardio ou imediato do cordão umbilical na mortalidade de recém-nascidos em relação à idade e características gestacionais. Métodos: Foi realizado uma pesquisa bibliográfica de abordagem qualitativa e caráter descritivo por meio de uma revisão integrativa da literatura nas bases de dados National Library of Medicine, Biblioteca Virtual em Saúde e Directory of Open Access Journals com os descritores: “Umbilical Cord Clamping” e “Neonatal Mortality”. Os critérios de inclusão foram ensaios clínicos, randomizados, não randomizados, estudos de caso-controle, estudo de coorte, livre acesso, publicados em inglês, português, espanhol e no intervalo de 2017 a 2022. Resultados: Os 13 artigos selecionados, foram avaliados e foi construído um quadro comparativo, na qual é composta pelo número de indivíduos abordados nos estudos, ano de publicação, avaliado se o clampeamento tardio ou imediato de acordo com o desfecho e idade gestacional. Considerações finais: Dessa forma, viu-se que, apesar de não reduzir a mortalidade infantil, isso é benéfico na redução da necessidade de hemotransfusões na faixa gestacional de 23 a 37 semanas.
Robotics in neurosurgery: Current prevalence and future directions
Authors: Singh Rohin , Wang Kendra , Qureshi Muhammad Bilal , Rangel India C. , Brown Nolan J. , Shahrestani Shane , Gottfried Oren N. , Patel Naresh P. , Bydon Mohamad 
Published: August 2022

Background:
The first instance of a robotic-assisted surgery occurred in neurosurgery; however, it is now more common in other fields such as urology and gynecology. This study aims to characterize the prevalence of robotic surgery among current neurosurgery programs as well as identify trends in clinical trials pertaining to robotic neurosurgery.

Methods:
Each institution’s website was analyzed for the mention of a robotic neurosurgery program and procedures. The future potential of robotics in neurosurgery was assessed by searching for current clinical trials pertaining to neurosurgical robotic surgery.

Results:
Of the top 100 programs, 30 offer robotic cranial and 40 offer robotic spinal surgery. No significant differences were observed with robotic surgical offerings between geographic regions in the US. Larger programs (faculty size 16 or over) had 20 of the 30 robotic cranial programs (66.6%), whereas 21 of the 40 robotic spinal programs (52.5%) were at larger programs. An initial search of clinical trials revealed 223 studies, of which only 13 pertained to robotic neurosurgery. Spinal fixation was the most common intervention (six studies), followed by Deep Brain Stimulation (DBS, two studies), Cochlear implants (two studies), laser ablation (LITT, one study), and endovascular embolization (one study). Most studies had industry sponsors (9/13 studies), while only five studies had hospital sponsors.

Conclusion:
Robotic neurosurgery is still in its infancy with less than half of the top programs offering robotic procedures. Future directions for robotics in neurosurgery appear to be focused on increased automation of stereotactic procedures such as DBS and LITT and robot-assisted spinal surgery.
Analisa Proses Bisnis Dan Model Bisnis Pada Platform E-commerce Syariah Salamin.Id
Authors: Putri Indah Permatasari  , Masruchin  
Published: August 2022

Pesatnya perkembangan internet memunculkan inovasi konsep dan praktik dalam perdagangan secara elektronik atau disebut dengan e-commerce. Hal tersebut dapat menjadi peluang untuk mengoptimalkan implementasi model bisnis syariah dalam pengembangan platform e-commerce. Sementara yang menjadi objek penelitian adalah platform e-commerce syariah Salamin.id. Metode penelitian yang digunakan dalam penelitian ini adalah kualitatif dengan pendekatan deskriptif untuk mendeskripsikan dan menjelaskan bagaimana penerapan Bussines Model Canvas (BMC) pada platform e-commerce Salamin.Id. Teknik pengumpulan data dalam penelitian ini dilakukan secara langsung melalui wawancara pada pihak Salamin.Id. Penelitian ini bertujuan untuk mengetahui proses dan model bisnis yang ada pada e-commerce syariah Salamin.id yang menggunakan akad salam dan Bussines Model Canvas (BMC). Dari penelitian ini akan digambarkan mengenai permodelan bisnis dari platform salamin.id dan bagaimana implementasi akad salam dapat dilakukan pada bisnis platform salamin.id. Hasil penelitian mengemukakan bahwa pengembangan platform ecommerce harus memperhatikan model bisnisnya terlebih dahulu sehingga dapat mengetahui jenis akad apa yang harus diimplementasikan sesuai dengan nilai kepatuhan syariah. Hasil penelitian menunjukkan 9 komponen platform design yang menggambarkan aktivitas bisnis pada platform Salamin.id.
Development Status and Project Interpretation of the Robotics Wushu Competition
Authors: Liu Xudong , Xin Le 
Published: August 2022

The Robotics Wushu Competition is a robotics competition that integrates intelligent robotics technology with traditional Chinese Wushu culture, maker spirit, and ideas. It is a highly confrontational and ornamental project in robotics competitions. This paper discusses the current situation, development status, and project settings of the Robotics Wushu Competition in the three major national competitions, focusing on the interpretation of several major projects, such as humanoid autonomous fighting, body-feeling humanoid fighting, wheeled autonomous fighting, visual confrontation, and unmanned aerial vehicle (UAV) confrontation. Finally, suggestions are proposed to support the regular holding and development of the Robotics Wushu Competition.
Analisis Hygiene Sanitasi Kapal Di Wilayah Pelabuhan Tanjung Perak Surabaya
Authors: DIYANAH KHULIYAH CANDRANING , Khanifah Akhmad Abu , Pawitra Aditya Sukma 
Published: August 2022

Sanitation checks are carried out to assess all sanitary conditions related to the presence of environmental risk factors on the ship. This study aims to analyze ship sanitation hygiene in the Port of Tanjung Perak, Surabaya City in August 2019. This research was an observational study with a cross-sectional approach. Data collection qualitatively by observation following the ship sanitation inspection and interview forms. A sample of 10 ships consisting of 9 cargo ships and 1 passenger ship in which the sample category is a ship that docked or berthed in the Tanjung Perak Port area of Surabaya City and has expired the sanitation certificate of the ship. Data analysis using descriptive methods. The results of ship sanitation hygiene checks with Permenkes Number 40 of 2015 concerning Ship Sanitation Certificate. Nine out of ten vessels inspected (90%) had sanitary hygiene that met the requirements, while 1 ship (10%) did not meet the sanitation hygiene requirements, namely passenger ships. Passenger ship parts that do not meet the requirements are kitchen, pantry, warehouse, and sleeping room. There is a vector of cockroaches and flies, as well as signs of rodent life (rats). Vessels resting at the port of Tanjung Perak have fulfilled hygiene and sanitation requirements based on Permenkes Number 40 of 2015 concerning Ship Sanitation Certificate.
Kondisi Populasi Rafflesia patma Blume di Cagar Alam Pananjung Pangandaran Jawa Barat
Authors: Mukmin Husein , Hikmat Agus 
Published: August 2022

Rafflesia patma Blume is placed as one of the CRB2c endangered status. It refers to the taxon who face the highest extinction in the short periode of time. The flower scarce is caused by a live factor of R. patma that need specific habitats such as physical and biotic factors. The habitats and population of R. patma will be charge on fluctuation due to the higher human activities and nature's changes. The study on population of R. patma in CA Pananjung Pangandaran (CAPP) was conducted. The results indicated that R. patma founded 312 individuals which distributed in 6 locations. This condition indicated that CAPP is suitable from R. patma.
Keywords: Rafflesia patma, population, endangered, extinction, biotoc factor
Reproduksi Phaleria spp. di Kebun Raya Bogor dan Upaya Konservasinya
Authors: Hidayat Syamsul 
Published: August 2022

Reproduction Habits (Flowering, Fruitting and germination) of Phaleria spp. at Bogor Botanical Garden, One Step Towards Its Conservation. Phaleria is potensial genus for ornamental and medicinal plant. This genus consist of 38 species in the world, of which distributed in Indonesia particularly in Sulawesi and Papua, three of them are conserved at Bogor Botanical Garden. In some countries, the plants have been used for medical treatments, craft, food sources, and ornamental plant. As a preliminary research for the next conservation effort, an evaluating of flowering/fruitting season and generation growth of Phaleria collection was studied. The reason of the research, there is no many seed on the garden grow as a seedling. So the germination studied on the nuresry. The result show tahat January to March as a peak season for flowering/fruitting of Phaleria. The germination rate is very fantastic, 10% of seed have been germinated one day after planted. The result also shows that the fallen seed have germinated higher than picked seed. A thick manure on the land and low sunlight penetration might be the problems on the garden for growing seedling of Phaleria.

Keywords: Phaleria, flowering/fruitting season, germination, and conservation.
Analisis Genetika: Sebuah Catatan Singkat Mengenai Penerapannya pada Suku Cervidae (Rusa dan Kijang)
Authors: Noor Ivan Yusufi , Suzanna Erna 
Published: August 2022

This papaer presents a bref note of genetically based studyof Cervidae. Many genetically based studies were performed on Cervids n last 20 years, and thidse are about many species, aspects and objectives. Most of these study using genetic analysis as the basic methods, and those objectives are : (1) to reveal genetic variability among populationa or individuals; to determine sex, individual, subspecies or species; to perform phylogenetic relationship and evolution and forensics. The importance of those kind of studies are reveal a variety of genetics informations that are relevant and usefull for population management and conservation. Using allof informations that are releaved from previous and recent study, it is possible to applying genetic analysis on Cervids of Indonesia. Genetics markers and methods that are necessary for these kind of study have been availbe, and the objectives of study, such as 5 species of deer and muntak of Indonesia, were ready to be explored.

Keywords: Cervidae, Genetics Analysis, Genetic Markers, Objectives and Methods
CONDITION AND DEVELOPMENT OF UNPLANNED TOURISM BUSINESS IN TASIKMALAYA DISTRICT
Authors: - Muhammad Indra Gunawan , Sunarminto Tutut , Sudrajat Adjat 
Published: August 2022

Tourism activities in Tasikmalaya Regency were recorded to experience fluctuations in the number of tourist visits from year to year. There are two classifications of tourist objects in Tasikmayala Regency, namely legal and registered tourist objects and tourist objects that are not legal and not yet registered in the Disparpora Tasikmalaya Regency and the Disparbud of West Java Province. Tourism objects that are not yet legal, have not been recorded, grow from the initiative of tourists or the community, and are not yet well established in their management are referred to as unplanned tourism businesses. The study was conducted to describe the conditions and developments in the unplanned tourism business carried out in three locations, namely Pasir Kirisik, Bukit Panyangrayan, and Bukit Puji Ningrum by conducting direct observations, interviews, and questionnaires. All data collected were then analyzed descriptively covering the general condition of the research location, characteristics of tourists and local communities, perceptions, motivations, preferences, participation, and conditions of business development factors in each research location. The condition of the unplanned tourism business shows that it is running well even though it has not run optimally and is accepted by tourists and the local community. So it is important the role of stakeholders according to their capacity and capability as part of the support system for procedural acceleration of an unplanned tourism business into an established ecotourism business.

Key words: acceleration, ecotourism, established, intuitive, tourism business