bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electro-mechano responsive elastomers with self-tuneable conductivity and stiffness
Authors: Yun Guolin , Cole Tim , Zhang Yuxin , Zheng Jiahao , Sun Shuaishuai , Ou-yang Yiming , Shu Jian , Lu Hongda , Zhang Qingtian , Wang Yongjing , Pham Duc , Hasan Tawfique , Li Weihua , Zhang Shiwu , Tang Shiyang 
Published: September 2022

Abstract
Materials with programmable conductivity and stiffness offer new design opportunities for next-generation engineered systems in soft robotics and wearable devices. However, existing approaches fail to harness variable electrical and mechanical properties synergistically, and lack the ability to self-respond to environmental changes. We report an electro-mechano responsive Field’s metal hybrid elastomer (FMHE) exhibiting variable and tuneable conductivity, strain sensitivity, and stiffness. By synergistically harnessing these properties, we demonstrate two applications with over an order of magnitude performance improvement compared to state-of-the-art, including a self-triggered multi-axis compliance compensator for robotic manipulators, and a resettable, highly compact, and fast current-limiting fuse with adjustable fusing current. We envisage that the extraordinary electromechanical properties of our hybrid elastomer will bring significant advancements in resilient robotic systems, intelligent instruments, and flexible electronics.
Ofloxacin-loaded Selenium-tellurium Nanoheterojunctions for Skin Infection and Wound Healing
Authors: Gao Ping , Sun Meng , Li Leijiao , Li Xiangyang , Wang Bao , Xu Yan , Sun Jing , Chen Jiajun , Li Wenliang 
Published: September 2022

Abstract
Background: With the increasing of antibiotic-resistant bacteria, the effectiveness of antibiotic treatment has decreased, which poses considerable threats to public health. Synergistic therapy for bacterial infection has attracted extensive attention due to its rapid, high efficiency and low toxicity.
Results: In this work, High performance and bioactive selenium tellurium nanoheterojunctions (TeSe) was synthesized by one-step hydrothermal method. TeSe nanomaterials have high photothermal conversion efficiency (81.4%) and excellent photostability under 808 nm laser irradiation. Combined therapeutic nanoplatform was constructed by loading with ofloxacin (OFLX) based on TeSe nanomaterial as a NIR photothermal agent and carrier. Under physiological conditions, a small amount of drug release was observed, and NIR irradiation could effectively enhance OFLX release. In vitro antibacterial experiments indicated that combined with antibiotic and photothermal therapy had significant antibacterial activity against gram-negative bacteria Escherichia coli (E. coli) and gram-positive bacteria Staphylococcus aureus (S. aureus). In addition, animal experiments further demonstrated that the combination therapy exhibited excellent bactericidal activity and promoted wound healing of infection. Such combined treatment strategy not only avoids damage to surrounding tissues in PTT, but also reduces antibiotic use and delays the development of antibiotic resistance.
Conclusions: Therefore, this work reveals the potential of antibiotic-photothermal combined therapy nanoplatform in the field of antibacterial applications, providing a novel strategy for the treatment of infectious diseases.
Association of General and Central Obesity, and Their Changes with Risk of Knee Osteoarthritis: A Nationwide Population-Based Cohort Study
Authors: Park Dojoon , Park Yong-Moon , Ko Seung-Hyun , Hyun Kang-Se , Choi Youn-Ho , Min Dong-Uk , Han Kyungdo , Koh Hae-Seok 
Published: September 2022

Abstract
In this study, we aimed to evaluate the association between general and central obesity, and their changes with risk of knee OA using retrospective cohort data collected from the Korean National Health Insurance Service. We studied 1,139,463 people aged 50 and over who received a health examination in 2009. To evaluate the association between general and/or central obesity and knee OA risk, a Cox proportional hazard models were used. Additionally, we investigate knee OA risk according to the change in obesity status over 2 years for subjects who had undergone health examinations for 2 consecutive years. General obesity without central obesity (HR 1.281, 95% CI 1.270–1.292) and central obesity without general obesity (HR 1.167, 95% CI 1.150–1.184) were associated with increased knee OA risk than the comparison group. Individuals with both general with central obesity had the highest risk (HR 1.418, 95% CI 1.406–1.429). This association was more pronounced in women and younger age group. Remarkably, the remission of general or central obesity over two years was associated with decreased knee OA risk (HR 0.884; 95% CI, 0.867-0.902 ; HR 0.900; 95% CI, 0.884-0.916, respectively). The present study found that both general and central obesity were associated with increased risk of knee OA and the risk was highest when the two types of obesity were accompanied. Changes in obesity status have been confirmed to alter the risk of knee OA.
Genetic variants of MUC4 are associated with prevalence and mortality of colorectal cancer and exhibit synergistic effects with LDL-C levels
Authors: Kwon Min Jung , Lee Jeong Yong , Kim Eo Jin , Ko Eun Ju , Ryu Chang Soo , Cho Hye Jung , Jun Hak Hoon , Kim Jong Woo , Kim Nam Keun 
Published: September 2022

Abstract
As a disease with high mortality and prevalence rates worldwide, colorectal cancer (CRC) has been thoroughly investigated. Mucins are involved in the induction of CRC and regulation of intestinal homeostasis. However, the role of MUC4, which is a member of the mucin gene family, is controversial because it shows an association with either decreased susceptibility to or a worse prognosis of CRC. In our study, the multifunctional aspects of MUC4 were elucidated by genetic polymorphism analysis in a case-control study of 420 controls and 464 CRC patients. The MUC4 rs1104760 A>G polymorphism had a protective effect on CRC risk (AG, AOR = 0.537; GG, AOR = 0.297; dominant model, AOR = 0.493; recessive model, AOR = 0.382). In addition, the MUC4 rs2688513 was associated with an increased mortality rate of CRC (5 years, GG, adjusted HR = 6.496; recessive model, adjusted HR = 5.848). Furthermore, a significant synergistic effect was observed between MUC4 rs1104760 A>G and low-density lipoprotein cholesterol (LDL-C) indicating a high potential as a biomarker for CRC susceptibility. This is the first study to indicate a significant association between MUC4 genetic polymorphisms and CRC prevalence, suggesting a functional genetic variant with the LDL-C level, for CRC prevention.
Analysis of Clinical Implications and Immune Landscape in Prognostic Model based on Immune Cell Signatures for Lung Adenocarcinoma Patients
Authors: Gao Weitong , Zhou Yang , Zong Yuxuan , Wang Nana , Nanding Abiyasi , Yu Yan 
Published: September 2022

Abstract
Lung cancer is the most common cancer type and major cause of death from malignancy worldwide. Immune cells such as lymphocytes infiltrated in tumor are identified as strong prognostic biomarkers for lung adenocarcinoma (LURD) patients. In our research, based on immune cell signatures infiltrated in tumor immune microenvironment, we developed and verified a risk score model by selecting six valuable prognostic genes: CD1C, CR2, MS4A1, SFTPC, STAP1 and TFF1 for risk stratification and survival prediction in LURD patients. Furthermore, the associations of risk score with tumor-infiltrating immune cells, immunotherapy-related biomarkers and immune checkpoints were also evaluated. Based on above, we made conclusions that the risk score model as a robust prognosis biomarker can screen the population who can benefit potentiallyfrom immunotherapy, thus improving diagnostic accuracy and optimizing clinical decision in LURD management.
Prediction of femoral head necrosis after Garden type I fracture with CT three-dimensional reconstruction
Authors: Zhan Hongqi , Ma Jianxiong , Cui Shuangshuang , Sun Lei , Jin Hongzhen , Wang Ying , Bai Haohao , Lu Bin , Ma Xin-Long 
Published: September 2022

Abstract
Background: Too large posterior tilt after Garden type I femoral neck fracture may lead to femoral head necrosis, but the measurement of posterior tilt is not accurate. Therefore, this study used computed tomography (CT) three-dimensional (3D) reconstruction to measure the relationship between posterior tilt and femoral head necrosis.
Methods:A total of 110 patients with Garden type I femoral neck fracture admitted to Tianjin Hospital from 2016 to 2020 were retrospectively analyzed. According to whether femoral head necrosis occurred after operation, they were divided into femoral head necrosis group and non-necrosis group.3D reconstruction was used to measure the posterior tilt of femoral head. The clinical data between the two groups were compared, the risk factors of femoral head necrosis were analyzed by multivariate logistic regression, and the predictive value of posterior tilt on postoperative femoral head necrosis was evaluated by the receiver operating characteristic (ROC) curve.
Results: A total of 110 patients were followed up for 18-66 months (mean, 29 months). Necrosis occurred in 12 patients (10.9 %). Multivariate logistic regression analysis showed that BMI≥25kg/m2, reduction quality grade C, and posterior tilt≥20° were risk factors for femoral head necrosis. ROC curve analysis showed that the 3D measured posterior tilt had predictive value for postoperative femoral head necrosis, and the predicted cut-off value was 19.6°.
Conclusion: For patients with Garden type I fractures, BMI≥25kg/m2, reduction quality grade C, and posterior tilt≥20° were risk factors for femoral head necrosis after closed reduction and internal fixation. The measurement of posterior tilt by CT 3D reconstruction can better predict the occurrence of femoral head necrosis in patients with Garden type I.
Breath-by-breath P0.1 measurement without airway occlusion may result in underestimation of respiratory drive
Authors: Takane Ryo , Nakajima Mikio , Miwa Maki , Kaszynski Richard H. , Nakano Tomotsugu , Goto Hideaki , Takeuchi Muneyuki 
Published: September 2022

Abstract
We aimed to identify the threshold for P0.1 in a breath-by-breath manner measured without airway occlusion for high respiratory drive. In this prospective observational study, we found P0.1 measured without airway occlusion, esophageal P0.1 and esophageal pressure swing had a positive correlation. However, the P0.1 threshold for high respiratory drive was calculated at approximately 1.0 cmH2O from the regression equation. Our calculations suggest a lower threshold of P0.1 measured without airway occlusion than that which has been previously reported.
Low FBXL7 Expression Indicates Low Overall Survival in Bladder Cancer
Authors: Xia Qier , Hu Xinyue , Li Jun , Shen Yifan , Wei Haibin , Qian Jing , Zhang Dahong 
Published: September 2022

Abstract
Background: F-box/LRR-repeat protein 7 (FBXL7) is a ubiquitin ligase associated with a poor prognosis in a variety of cancers. However, its prognostic value in bladder cancer has not been established. We evaluated the clinicopathological characteristics of FBXL7 and its predictive significance in bladder cancer (BLCA).
Methods: Gene Expression Omnibus（GEO）and The Cancer Genome Atlas (TCGA) were used for a comprehensive investigation of the mRNA expression profile of BLCA. The diagnostic value of FBXL7 in TCGA-BLCA was verified using receiver operating characteristic curves. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses as well as a gene set enrichment analysis were performed. Bladder cancer and paracancerous tissues were collected in clinic, and Immunohistochemical(IHC) verified the expression of FBXL7.
Results: Genes co-expressed with FBXL7were enriched for extracellular matrix structural components, transmembrane receptor protein kinase activity, as determined by a GO enrichment analysis. A KEGG pathway enrichment analysis revealed that the co-expressed genes were related to the cell cycle, mitogen-activated protein kinase signaling pathway. Patients with low levels of FBXL7 expression had a worse prognosis than that of patients with high expression levels, according to a Kaplan–Meier survival analysis. IHC results showed high expression of FBXL7 in paracancerous tissues and low expression in bladder cancer tissues.
Conclusion: The differentially expressed genes identified in this study clarify the molecular pathways leading to BLCA. Our results indicate that FBXL7 may improve clinical decision-making in BLCA and is an indicator of poor survival.
Bayesian optimization with constraints based on explanation-based learning and its application in materials research
Authors: Ohno Hiroshi 
Published: September 2022

Abstract
The present paper describes an algorithm for improving the convergence of Bayesian optimization (BO) using the constraints derived from symbolic learning and inference for observations by explanation-based learning (EBL). During the BO process, the constraints based on observations generalized by the domain knowledge (theory) of EBL are applied to maximization of the acquisition function, thereby improving the efficiency of exploration. For the maximization, a (1 + 1)-evolutionary strategy is exploited to incorporate the constraints. In addition, knowledge regarding the improvements is provided as a human-readable representation, which is reflected by the domain theory. Using synthetic and real-world data provided by experiments of lithium-ion batteries to maximize ionic conductivity, the effectiveness of the proposed algorithm is demonstrated. The obtained knowledge is reasonable in the domain theory regarding high ionic conductivity. Thus, the effect of improving explainability for the optimization is shown.
Investigating the Effects of Maltreatment and Acute Stress on the Concordance of Blood and DNA Methylation Methods of Estimating Immune Cell Proportions
Authors: Apsley Abner T. , Etzel Laura , Hastings Waylon J. , Heim Christine C. , Noll Jennie G. , O’Donnell Kieran J. , Schreier Hannah M. C. , Shenk Chad E. , Ye Qiaofeng , Shalev Idan 
Published: September 2022

Abstract
Background:
Immune cell proportions can be used to detect pathophysiological states and are also critical covariates in genomic analyses. The complete blood count (CBC) is the most common method of immune cell proportion estimation, but immune cell proportions can also be estimated using whole-genome DNA methylation (DNAm). Although the concordance of CBC and DNAm estimations has been validated in various adult and clinical populations, less is known about the concordance of existing estimators among stress-exposed individuals. As early life adversity and acute psychosocial stress have both been associated with unique DNAm alterations, the concordance of CBC and DNAm immune cell proportion needs to be validated in various states of stress.
Results:
We report the correlation and concordance between CBC and DNAm estimates of immune cell proportions using the Illumina EPIC DNAm array within two unique studies: Study 1, a high-risk pediatric cohort of children oversampled for exposure to maltreatment (n=365, age 8 to 14 years), and Study 2, a sample of young adults who have participated in an acute laboratory stressor with four pre- and post-stress measurements (n=28, number of observations=100). Comparing CBC and DNAm proportions across both studies, estimates of neutrophils (r=0.948, p<0.001), lymphocytes (r=0.916, p<0.001), and eosinophils (r=0.933, p<0.001) were highly correlated, while monocyte estimates were moderately correlated (r=0.766, p<0.001) and basophil estimates were weakly correlated (r=0.189, p<0.001). In Study 1, we observed significant deviations in raw values between the two approaches for some immune cell subtypes, however, the observed differences were not significantly predicted by exposure to child maltreatment. In Study 2, while significant changes in immune cell proportions were observed in response to acute psychosocial stress for both CBC and DNAm estimates, the observed changes were similar for both approaches.
Conclusions:
Although significant differences in immune cell proportion estimates between CBC and DNAm exist, as well as stress-induced changes in immune cell proportions, neither child maltreatment nor acute psychosocial stress alters the concordance of CBC and DNAm estimation methods. These results suggest that the agreement between CBC and DNAm estimators of immune cell proportions is robust to exposure to child maltreatment and acute psychosocial stress.
Robotic Repair of Non-Midline Hernias
Authors: Guo Alyssa , Isaac Dillon , Jaraczewski Liliana , Cobb William , Carbonell Alfredo , Warren Jeremy 
Published: September 2022

Abstract
Background
Non-midline abdominal wall hernias present unique anatomic challenges, making repair more complex. The constraints of the peritoneal cavity, pelvis, and costal margin limit the utility of intraperitoneal mesh repair, and extraperitoneal repairs have traditionally been performed using open techniques, often resulting in higher wound morbidity. Advances in minimally invasive surgery make visualization and dissection of such complex cases feasible, with all the attendant benefits of a minimally invasive over an open approach. In this study we examined the use of the robotic platform to repair non-midline hernias.
Methods
Retrospective review of all non-midline abdominal wall hernias performed robotically at Prisma Health, excluding parastomal hernias. Study conducted and outcomes reported according to STROBE statement.
Results
Repair was performed in the retromuscular space (n=42), preperitoneal (n=22), and intraperitoneal (n=1). Mean hernia width was 9.4cm, permanent synthetic mesh used for all repairs. Mean LOS was 1.5 days. Surgical site occurrence (SSO) occurred in 49.2%, 78% of which were simple seroma. Three patients (4.6%) developed surgical site infection (SSI). Two recurrences were identified with a mean follow-up of 11 mos.
Conclusion
The robotic platform facilitates complex dissection to allow minimally invasive, extraperitoneal repair of complex non-midline hernias. This approach overcomes the anatomic constraints of intraperitoneal mesh repair and the wound morbidity of open repair.
A robust fuzzy-stochastic optimization model for managing open innovation uncertainty in the ambidextrous supply chain planning problem
Authors: Rahmanzadeh Sajjad , Pishvaee Mir Saman , Rasouli Mohammad Reza 
Published: September 2022

Abstract
This paper studies the effect of the open innovation concept in the product design process and supply chain master planning. Complex uncertainties caused by using outbound resources within co-design processes, financial challenges between the collaborating parties, and integrating outbound innovative designs with supply chain tactical planning problem are taken into account. To this end, a robust fuzzy-stochastic optimization model is proposed which can integrate the product design with the main activities of a multi-product supply chain. The proposed model is able to cope with different type of uncertainties including random, epistemic and deep uncertainties. Integrating the financial and physical flows, using a novel pricing mechanism, and considering the outside-in innovations in the product design process are the outstanding contributions of the proposed model. Furthermore, to cover both the short-term and long-term success criteria, ambidexterity of the studied supply chain is taken into account via two conflicting explorative and exploitive objectives. Results indicate the superiority of the presented model and its ability in supporting managerial decisions in the mid-term planning process.
Models and algorithms for U-shaped assembly line balancing problem with collaborative robots
Authors: Li Zixiang , Janardhanan Mukund , Tang Qiuhua , Zhang Zikai 
Published: September 2022

Abstract
The collaborative robot (cobot) are increasingly being utilized in industries due to the advancement in the field of robotic technology and also due the increase in labor costs. The cobots on the assembly line can be utilized to complete the tasks independently or assist the workers to complete the tasks. This study considers the U-shaped assembly line balancing problem with cobots, where several cobots with different purchasing costs are selected under the budget constraint. Three mixed-integer programming models are formulated to optimize the cycle time and the built models are capable of solving the small-sized instances optimally. Two algorithms, artificial bee colony algorithm and migrating bird optimization algorithm are developed and improved to tackle the large-sized instances, where new encoding scheme and decoding procedure are developed for this new problem. The computational tests demonstrate that the utilization of collaborative robots reduces the cycle time effectively in the assembly line. The comparative study on a set of instances shows that the proposed methodologies obtain competing performance in comparison with other 12 implemented algorithms.
Prodrugs of Nucleoside 5'-Monophosphate Analogues: Overview of
the Recent Literature Concerning their Synthesis and Applications
Authors: Roy Béatrice , Navarro Valentin , Peyrottes Suzanne 
Published: September 2022

Abstract:
Nucleoside analogues are widely used as anti-infectious and antitumoral
agents. However, their clinical use may face limitations associated with their physicochemical
properties, pharmacokinetic parameters, and/or their peculiar mechanisms of action.
Indeed, once inside the cells, nucleoside analogues require to be metabolized into
their corresponding (poly-)phosphorylated derivatives, mediated by cellular and/or viral
kinases, in order to interfere with nucleic acid biosynthesis. Within this activation process,
the first-phosphorylation step is often the limiting one and to overcome this limitation,
numerous prodrug approaches have been proposed. Herein, we will focus on recent literature
data (from 2015 and onwards) related to new prodrug strategies, the development of
original synthetic approaches and novel applications of nucleotide prodrugs (namely pronucleotides)
leading to the intracellular delivery of 5’-monophosphate nucleoside analogues.
The Correlation Between Modified Total Cerebral Small Vessel Disease
Score and Gait and Balance Disorder in Middle-aged to Older Adults
Authors: Hu Wenli , Hou Yutong , Yang Shuna , Li Yue , Qin Wei , Yang Lei 
Published: September 2022

Background and purpose:
The aim of this study is to investigate the relationships between the original and modified total cerebral small vessel disease (CSVD) score and gait and balance impairment using quantitative and semi-quantitative tests.

Methods:
In our study, patients aged 45 to 85 years were recruited consecutively.
CSVD manifestations were identified with brain magnetic resonance imaging (MRI), and the original and modified CSVD scores were calculated based on the results. Gait and balance function were assessed using both gait parameters and clinical rating scales. The correlation between the original and modified total scores of the CSVD and gait and balance dysfunction was demonstrated.

Results:
224 patients were enrolled in the study. Gait and balance disorders were associated with both the original and modified CSVD scores. A significant association remained after adjusting for gender, height, age, hypertension, and other relevant risk factors. The binary logistic regression and chi-squared trend tests revealed that impairment of movement function significantly correlated with the modified CSVD score and that the dysfunction was significantly higher for patients with modified CSVD scores of 5-6 than those with scores of 1-2. In receiver operating characteristic (ROC) analysis, modified CSVD scores were more accurate in predicting gait impairment than original CSVD scores.

Conclusion:
We found both original and modified total CSVD scores to be related to gait and balance disorder, and the modified CSVD score was more accurate in identifying movement impairment and should be used as an effective tool in investigating CSVD and motor dysfunction.