bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autonomic Nervous System Dysfunction Is Associated With Re-hospitalization in Pediatric Septic Shock Survivors
Authors: Badke Colleen M. , Swigart Lindsey , Carroll Michael S. , Weese-Mayer Debra E. , Sanchez-Pinto L. Nelson 
Published: January 2022

Objective: Re-hospitalization after sepsis can lead to impaired quality of life. Predictors of re-hospitalization could help identify sepsis survivors who may benefit from targeted interventions. Our goal was to determine whether low heart rate variability (HRV), a measure of autonomic nervous system dysfunction, is associated with re-hospitalization in pediatric septic shock survivors.Materials and Methods: This was a retrospective, observational cohort study of patients admitted between 6/2012 and 10/2020 at a single institution. Patients admitted to the pediatric intensive care unit with septic shock who had continuous heart rate data available from the bedside monitors and survived their hospitalization were included. HRV was measured using age-normalized z-scores of the integer HRV (HRVi), which is the standard deviation of the heart rate sampled every 1 s over 5 consecutive minutes. The 24-h median HRVi was assessed on two different days: the last 24 h of PICU admission (“last HRVi”) and the 24-h period with the lowest median HRVi (“lowest HRVi”). The change between the lowest and last HRVi was termed “delta HRVi.” The primary outcome was re-hospitalization within 1 year of discharge, including both emergency department encounters and hospital readmission, with sensitivity analyses at 30 and 90 days. Kruskal-Wallis, logistic regression, and Poisson regression evaluated the association between HRVi and re-hospitalizations and adjusted for potential confounders.Results: Of the 463 patients who met inclusion criteria, 306 (66%) were re-hospitalized, including 270 readmissions (58%). The last HRVi was significantly lower among re-hospitalized patients compared to those who were not (p = 0.02). There was no difference in the lowest HRVi, but patients who were re-hospitalized showed a smaller recovery in their delta HRVi compared to those who were not re-hospitalized (p = 0.02). This association remained significant after adjusting for potential confounders. In the sensitivity analysis, a smaller recovery in delta HRVi was consistently associated with a higher likelihood of re-hospitalization.Conclusion: In pediatric septic shock survivors, a smaller recovery in HRV during the index admission is significantly associated with re-hospitalization. This continuous physiologic measure could potentially be used as a predictor of patients at risk for re-hospitalization and lower health-related quality of life.
Incidence and Prevalence Trends of Pediatric Inflammatory Bowel Disease in the Daegu-Kyungpook Province From 2017 to 2020
Authors: Choe Jae Young , Choi Sujin , Song Ki Hwan , Jang Hyo-Jeong , Choi Kwang-Hae , Yi Dae Yong , Hong Suk Jin , Hwang Jun Hyun , Cho Seung-Man , Kim Young Jin , Choe Byung-Ho , Kang Ben 
Published: January 2022

Background and Aim: There is paucity of data regarding the epidemiology of pediatric IBD in Asia compared to that of Western countries. We aimed to investigate the incidence and prevalence trends of pediatric inflammatory bowel disease (IBD) in the Daegu-Kyungpook province of South Korea from 2017 to 2020.Methods: This study was a multicenter, retrospective study conducted in eight IBD referral centers located in the Daegu-Kyungpook province. Children and adolescents of ≤18 years who were initially diagnosed with IBD between 2017 and 2020 were included. The annual number of children and adolescents newly diagnosed with IBD and the annual resident population of children and adolescents ≤18 years of age in the Daegu-Kyungpook province were investigated to calculate the annual incidence and prevalence in the region.Results: A total 304 children and adolescents that had been diagnosed with IBD were included in this study. Among these patients, 71.4% had been diagnosed with Crohn's disease (CD), and 28.6% with ulcerative colitis (UC). The population based annual incidences of IBD from 2017 to 2020 were each 7.24, 6.82, 10.27, and 13.33 per 100,000, respectively (P for trend &lt;0.001), 4.48, 5.26, 7.39, and 9.8 per 100,000, respectively, for CD (P for trend &lt;0.001), and 2.76, 1.56, 2.88, and 3.53 per 100,000, respectively, for UC (P for trend = 0.174).Conclusion: Pediatric IBD, especially CD has significantly increased recently in the Daegu-Kyungpook province. Epidemiology studies from other regions of Asia are required to better elucidate this trend of increase in Asia.
Effectiveness of a Hydrophilic Curcumin-Based Formulation in Coadjuvating the Therapeutic Effect of Intravitreal Dexamethasone in Subjects With Diabetic Macular Edema
Authors: Parravano Mariacristina , Allegrini Davide , Carnevali Adriano , Costanzo Eliana , Giannaccare Giuseppe , Giorno Paola , Scorcia Vincenzo , Spedicato Giorgio Alfredo , Varano Monica , Romano Mario R 
Published: January 2022

Purpose: This study evaluates if the addition of a curcumin formulation with a polyvinylpyrrolidone-hydrophilic carrier (CHC; Diabec®, Alfa Intes, Italy) to intravitreal injections of dexamethasone (DEX-IVT) can affect the morphological retinal characteristics, extending the steroid re-treatment period in patients with diabetic macular edema (DME).Methods: A randomized controlled clinical trial was carried out in DME patients, randomly assigned to receive DEX-IVT or DEX-IVT and a CHC. The evaluation of the mean difference of central retinal thickness (CRT) was the primary aim. Secondary aims were the evaluations of best-corrected visual acuity, differences in the predetermined retinal layer thickness, the number/time of re-treatment, and the assessment of safety.Results: A total of 73 DME patients were included (35 in the control group and 38 in the combined therapy group). In both the control and combined therapy groups, the mean CRT change from T0 to the 6 months’ evaluation was significant (p = 0.00). The mean CRT result was significantly different at month 4 (p = 0.01) between the control and combined therapy groups, with a greater reduction in the combined therapy group, in particular, in patients with ≤10 years of diabetes. A trend of CRT reduction in the combined therapy group has been observed also considering patients with subfoveal neuroretinal detachment. In addition, we observed that the reduction of inner retinal layer thickness was greater in the combination group, in comparison with controls.Conclusion: The combination of a CHC to DEX-IVT is a promising therapeutic option in case of DME, in particular, for patients with early-stage diabetes and with an inflammatory phenotype. Further studies will be necessary to confirm these findings.
Ultrasound-Induced Destruction of Nitric Oxide–Loaded Microbubbles in the Treatment of Thrombus and Ischemia–Reperfusion Injury
Authors: Liang Zenghui , Chen Huafang , Gong Xuehao , Shi Binbin , Lin Lili , Tao Fangyi , Wu Qilong , Fang Mingling , Li Hui , Lu Cuitao , Xu Helin , Zhao Yingzheng , Chen Bin 
Published: January 2022

Objectives: Early recanalization of large vessels in thromboembolism, such as myocardial infarction and ischemic stroke, is associated with improved clinical outcomes. Nitric oxide (NO), a biological gas signaling molecule, has been proven to protect against ischemia–reperfusion injury (IRI). However, the underlying mechanisms remain to be explored. This study investigated whether NO could mitigate IRI and the role of NO during acoustic cavitation.Methods:In vivo, thrombi in the iliac artery of rats were induced by 5% FeCl3. NO-loaded microbubbles (NO-MBs) and ultrasound (US) were used to treat thrombi. B-mode and Doppler US and histological analyses were utilized to evaluate the thrombolysis effect in rats with thrombi. Immunohistochemistry, immunofluorescence, and western blotting were conducted to investigate the underlying mechanisms of NO during acoustic cavitation. In vitro, hypoxia was used to stimulate cells, and NO-MBs were employed to alleviate oxidative stress and apoptosis.Results: We developed NO-MBs that significantly improve the circulation time of NO in vivo, are visible, and effectively release therapeutic gas under US. US-targeted microbubble destruction (UTMD) and NO-loaded UTMD (NO + UTMD) caused a significant decrease in the thrombus area and an increase in the recanalization rates and blood flow velocities compared to the control and US groups. We discovered that UTMD induced NO generation through activation of endothelial NO synthase (eNOS) in vivo. More importantly, we also observed significantly increased NO content and eNOS expression in the NO + UTMD group compared to the UTMD group. NO + UTMD can mitigate oxidative stress and apoptosis in the hind limb muscle without influencing blood pressure or liver and kidney functions. In vitro, NO-MBs alleviated oxidative stress and apoptosis in cells pretreated with hypoxia.Conclusion: Based on these data, UTMD affects the vascular endothelium by activating eNOS, and NO exerts a protective effect against IRI.
Aerobic Exercise Combination Intervention to Improve Physical Performance Among the Elderly: A Systematic Review
Authors: Bai Xiaorong , Soh Kim Geok , Omar Dev Roxana Dev , Talib Othman , Xiao Wensheng , Soh Kim Lam , Ong Swee Leong , Zhao Chenyang , Galeru Ovidiu , Casaru Catalina 
Published: January 2022

The benefits of aerobic exercise for the elderly are well-known. They extend beyond cardiovascular changes and can reduce the inactivity-induced loss of strength, mobility, balance, and endurance that are vital for the safe performance of daily activities in older adults. However, the benefits of combined aerobic exercise with other exercises such as strength/resistance, multi-component and aerobic exercise remain unknown. The purpose of this study is to examine the effects of combined aerobic exercise on physical performance among the elderly, as opposed to single aerobic exercise. We searched four databases of SCOPUS, PubMed, EBSCOhost, and CINAHL Plus to find 18 articles that met criteria. Data was extracted using PICOs extraction tool and summarized using a narrative synthesis approach. Studies have shown that aerobics combined resistance/strength training (CEX), multi-component training (ME), and dance combined training has positive and significant effects on the physical performance (upper body strength and lower body strength, dynamic balance, fall risk, mobility, gait, agility, flexibility) of the elderly. CEX had additional benefits compared to aerobic training (AER) and resistance/strength training (RES) in gait speed, lower limb strength, and trunk fat. Furthermore, CEX was more effective than AER in improving sitting and stretching, elbow flexion, knee flexion, shoulder flexion and stretching, strength and body fat, function reach test, 30-s chair standing test and 6-min walking test, self-evaluation of body function. Therefore, the combination of multiple components contributes to the overall improvement in physical fitness of the elderly, thus preventing them from losing balance and reducing susceptibility to injury.Clinical Trial Registration: [https://www.crd.york.ac.uk/prospero/#recordDetails], identifier [CRD42021213147].
Intergenerational Impact of Violence Exposure: Emotional-Behavioural and School Difficulties in Children Aged 5–17
Authors: Hashemi Ladan , Fanslow Janet , Gulliver Pauline , McIntosh Tracey 
Published: January 2022

Background and Objectives: The intergenerational impacts of parental exposure to violence during childhood and adulthood have largely been investigated separately. This limits our understanding of how cumulative violence exposure over a lifespan elevates the risk of subsequent generation's maladjustment. To address this, we examined if parental exposure to violence during childhood and during adulthood was associated with increased emotional-behavioural and school difficulties among the children of these parents. Further, we examined if parental exposure to cumulative violence increased the odds of their children experiencing difficulties.Participants and Setting: 705 participants (354 mothers and 351 fathers) from the 2019 New Zealand Family Violence Survey, a population-based study conducted in New Zealand between March 2017 and March 2019.Methods: Multivariable logistic regressions were conducted to ascertain the impact of parental exposure to violence on children's outcomes after adjustment for sociodemographic characteristics. The impact of parental cumulative violence exposure on children's outcomes was also explored.Results: Findings indicated that children of parents who had histories of exposure to violence during childhood were at increased risk for experiencing emotional-behavioural or school difficulties. However, where parents reported a history of childhood abuse but not adult experience of violence, their children had similar odds of experiencing difficulties as the children of parents who had not been exposed to any violence in their lifetime. Children of parents who had been exposed to violence only during adulthood were at higher risk of experiencing emotional-behavioural difficulties compared with children of parents with no violence exposure. Children of parents with histories of exposure to violence during both childhood and adulthood had the highest prevalence of experiencing emotional/behavioural and school difficulties.Conclusion: These findings highlight the intergenerational impacts of violence exposure and the complex intersections between parents' and children's life experiences. Our findings suggest the need for violence prevention initiatives to foster the development of safe, stable and nurturing relationships and to expand services for parents already exposed to violence to build resilience and to break the inter-generational cycle of disadvantage.
Blobs in a Solar EUV Jet
Authors: Chen Jie , Erdélyi Robertus , Liu Jiajia , Deng Yuanyong , Dover Fionnlagh Mackenzie , Zhang Qingmin , Zhang Mei , Li Leping , Su Jiangtao 
Published: January 2022

An Extreme Ultraviolet (EUV) jet that occurred around 22:30 on July 2, 2012 was observed by the Atmospheric Imaging Assembly (AIA) on-board the Solar Dynamics Observatory (SDO). There were two phases of the jet. In Phase 1, two blobs were observed. In Phase 2, the intensity of the jet was almost coherent initially. One minute later, three blobs were formed at the same time in the jet, and the width of the jet changed after the formation of these blobs. The formation and evolution processes of the blobs in these two phases are analyzed in this paper. The physical parameters of the blobs are determined. The measured width of the blobs is 0.8 − 2.3 Mm, and the apparent velocities of the blobs are from 59 km s−1 to 185 km s−1. The formation mechanism of the blobs is likely to be tear-mode instability.
Superionic Solid Electrolyte Li7La3Zr2O12 Synthesis and Thermodynamics for Application in All-Solid-State Lithium-Ion Batteries
Authors: Aleksandrov Daniil , Novikov Pavel , Popovich Anatoliy , Wang Qingsheng 
Published: January 2022

Solid-state reaction was used for Li7La3Zr2O12 material synthesis from Li2CO3, La2O3 and ZrO2 powders. Phase investigation of Li7La3Zr2O12 was carried out by x-ray diffraction (XRD), scanning electron microscopy (SEM) and energy-dispersive x-ray spectroscopy (EDS) methods. The thermodynamic characteristics were investigated by calorimetry measurements. The molar heat capacity (Cp,m), the standard enthalpy of formation from binary compounds (ΔoxHLLZO) and from elements (ΔfHLLZO), entropy (S0298), the Gibbs free energy of the Li7La3Zr2O12 formation (∆f G0298) and the Gibbs free energy of the LLZO reaction with metallic Li (∆rGLLZO/Li) were determined. The corresponding values are Cp,m = 518.135 + 0.599 × T − 8.339 × T−2, (temperature range is 298–800 K), ΔoxHLLZO = −186.4 kJ·mol−1, ΔfHLLZO = −9327.65 ± 7.9 kJ·mol−1, S0298 = 362.3 J·mol−1·K−1, ∆f G0298 = −9435.6 kJ·mol−1, and ∆rGLLZO/Li = 8.2 kJ·mol−1, respectively. Thermodynamic performance shows the possibility of Li7La3Zr2O12 usage in lithium-ion batteries.
Mapas conceptuales como herramienta de aprendizaje en estudiantes de Educación Superior
Authors: Valero Ancco Vidnay Noel , Calderon Quino Katty Maribel , Morales Chipana Elias , Cornejo Valdivia Gabriela 
Published: January 2022

La investigación tuvo como objetivo determinar la eficacia de los mapas conceptuales como herramienta de aprendizaje en estudiantes del Instituto Superior Tecnológico Público de Manú. La metodología corresponde al enfoque cuantitativo, con un diseño pre experimental de un solo grupo con pre y pos prueba. La muestra estuvo conformada por 30 estudiantes seleccionados bajo un criterio no probabilístico. Las técnicas de investigación corresponden al examen con el instrumento prueba de entrada y salida y la técnica de análisis de contenido con el instrumento rúbrica. Los resultados afirman la existencia de una diferencia entre el promedio que obtuvieron los estudiantes en la prueba de entrada en relación a la prueba de salida que se aplicó después del experimento, por lo tanto, se concluye que los mapas conceptuales son eficaces como herramienta de aprendizaje del módulo de cultura artística en estudiantes del Instituto Superior Tecnológico Público de Manú.
Comprensión estructural de textos escritos en estudiantes de nivel secundaria de Lima Metropolitana
Authors: Paucca Gonzales Nelson , Cobos Ruiz Cesar , Romaní Allende Freddy Gamaniel , Rafayle Cuadra Rusbel Jhon , Paucca Gonzales Hilarion 
Published: January 2022

Los problemas de comprensión de textos escritos en los estudiantes de los niveles de Educación Básica Regular en Perú, muestran cierto grado de deficiencia, por lo que la investigación tuvo como objetivo central, comparar la comprensión estructural de textos escritos en estudiantes de un colegio público y parroquial. Metodológicamente la investigación corresponde al método estadístico de enfoque cuantitativo, tipo básico–no experimental y de diseño causal comparativo. La información se obtuvo a través de la técnica de la encuesta y el instrumento denominado tipo de prueba. Esta última se aplicó a 130 estudiantes del grupo muestral. Finalmente, para el contraste de hipótesis se utilizó la prueba de Wilcoxon, la cual permitió concluir que no existen diferencias significativas estadísticas en la comprensión de textos escritos. Además, de las dimensiones de microestructura, macroestructura y superestructura en estudiantes de quinto grado de nivel secundaria de la ciudad de Lima – Perú.
Satisfacción laboral y cultura organizacional en docentes universitarios en una Facultad de Ciencias de la Salud
Authors: Díaz Tinoco Angélica , Valderrama Rios Olga Giovanna , Merino Lozano Alicia Lourdes , Nuñez Zarazú Llerme , Cuba Sancho Juana Matilde 
Published: January 2022

Identificar la relación de la cultura organizacional en la satisfacción laboral de los docentes de una universidad de la costa peruana. Investigación descriptiva, correlacional y transversal. La muestra fue de 48 docentes, obtenidos mediante muestreo aleatorio simple. Los instrumentos utilizados fueron dos; la escala de satisfacción laboral SL- SPC y otro para cultura organizacional, ambos en escala de Likert. Para los análisis estadísticos se usó la correlación de Spearman. El 66.7% presentó una cultura organizacional neutra, el 20.8% fuerte y el 12.5% débil. El 79.2% indicaron tener una satisfacción laboral media, 14.6% alta y solo el 6.3% baja. La cultura organizacional se relacionó con la satisfacción laboral de los docentes (r=0,375, p= 0,009).
Akuntansi DETERMINASI SISTEM PENGENDALIAN MUTU DAN SIKAP PROFESIONALISME AUDITOR TERHADAP KUALITAS AUDIT
Authors: Astuti Wati Aris , Nur Islamiati Suci Agustin 
Published: January 2022

Terdapat fenomena yang terjadi di Kantor Akuntan Kota Bandung dimana kualitas audit yang dihasilkan bermasalah dalam pelaksanaan tugasnya mengenai penerapan sistem pengendalian mutu dan sikap profesionalisme auditor sehingga terjadi penundaan izin untuk auditor. Tujuan
penelitian ini adalah untuk mengetahui, menganalisis, dan memahami bukti determinasi sistem pengendalian mutu dan sikap profesionalisme auditor terhadap kualitas audit pada Kantor Akuntan Publik di Kota Bandung.
Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan pendekatan analisis deskriptif dan analisis verifikatif, sampel yang digunakan adalah auditor senior, supervisor dan partner dari 19 Kantor Akuntan Publik di Kota Bandung yang terdaftar di Otoritas Jasa Keuangan sebanyak 47 responden dan alat analisis yang digunakan adalah Uji Validitas, Uji Reliabilitas, Uji Normalitas, Uji Multikolinieritas, Uji Heteroskedastisitas, Regresi Linear Berganda, Koefisien Determinasi, Koefisien korelasi, dan Uji t.
Hasil dari penelitian ini menunjukkan bahwa Sistem Pengendalian Mutu, Sikap Profesionalisme Auditor dan Kualitas Audit memiliki kriteria cukup baik.
Parâmetros antropométricos, bioquímicos como indicadores de riscos cardiovasculares em usuários de antipsicóticos / Anthropometric, biochemical parameters as indicators of cardiovascular risks in antipsychotic users
Authors: De Ataíde Bruno Rafael Batista , Pereira Glendson de Sousa , Rocha Naiara Carvalho , Guterres Aldair da Silva , Torres Rosileide de Souza 
Published: January 2022

Atualmente o tratamento mais eficaz para pacientes com transtornos mentais veem sendo os antipsicóticos, entretanto, o uso dessas drogas, tanto as de primeira geração quanto às de segunda geração, ocasionam importantes efeitos adversos. O presente trabalho tem como objetivo, avaliar os parâmetros antropométricos, bioquímicos e suas correlações como preditores de risco cardiovascular em usuários de antipsicóticos internados em um serviço de internação breve. Foram avaliados 113 pacientes, portadores de esquizofrenia internados em um hospital de referência em psiquiatria. Avaliou-se os parâmetros antropométricos, bioquímicos e suas correlações, com significância estatística de p < 0,05. Os resultados apresentaram que 50,4% dos avaliados apresentavam sobrepeso, dentre os lipídeos, os triglicerídeos com 153.8±24.1 mg/dL e o LDL-c 114.5±26.8 mg/dL estavam com as médias acima dos valores recomendados, ao correlacionar os parâmetros antropométricos e bioquímicos, demonstrou-se valores positivos, exceto para a correlação triglicerídeos e HDL-c, desmontando indicativos de risco para doenças cardiovasculares no público estudado. Concluímos que apesar dos efeitos positivos no controle das psicoses e auxilio na melhora dos transtornos mentais, os antipsicóticos geram alguns danos a níveis metabólicos nos seus usuários, propiciando o risco de complicações cardiovasculares e a presença de diabetes tipo 2, diminuindo assim a expectativa de vida desses pacientes.