bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduction system “vitamin C/glycerol” promoted copper(II)‐catalyzed N‐arylation
Authors: Wu Fengtian , Yan Fangming , Wu Ling , Zhang Caihong , Zeng Rong , Sun Yijia , Liu Xiuping , Cui Chunna , Wang Peng 
Published: January 2022

AbstractThe common access to forming CN bond is the copper‐catalyzed Ullmann‐type reaction. The relatively expensive and easily oxidized copper(I) is usually used in the reaction. Our group discovered that the “vitamin C/glycerol” reduction system could convert cheap and stable CuO to active low valence state copper species, as measured via X‐ray photoelectron spectroscopy (XPS), to promote the CN coupling reaction. In particular, 2‐phenylindole, pyrrolo[1,2‐a]quinoxaline, 1,2,4‐triazole and 4‐amino‐7H‐pyrrolo[2,3‐d]pyrimidine derivative were obtained in the presence of CuO and reduction system “vitamin C/glycerol.” This method provided a simple and cost‐effective approach to the preparation of N‐arylation products.
Toughening and reinforcing waste polypropylene with POE/nano‐SiO2 under elongational flow
Authors: He Hezhi , Gao Jun , Wang Yi , Zhu Zhiwen , Liu Yufan , Tian Guidong , Xu Li , Huang Zhaoxia 
Published: January 2022

AbstractDue to the white pollution, the recycling of waste plastics has attracted more and more attention. In this research, waste polypropylene/Ethylene‐octene elastomer/nano‐SiO2 composites (wPP/POE/SiO2) were melt‐blended using an Eccentric Rotor Extruder (ERE) dominated by elongational flow field and a Torque Rheometer (TR) dominated by shear flow field, respectively. The micromorphology, mechanical, crystallization, thermal and rheological properties of wPP/POE/SiO2 blends were studied. Compared to the blends fabricated by TR, the wPP/POE/SiO2 blends with different compositions fabricated by ERE showed higher tensile strength, flexural strength, and modulus. Particularly, without sacrificing the tensile strength, the notched impact strength of the wPP/POE/SiO2 blends fabricated by ERE increased to 13.53 kJ/m2, a factor of 3 times larger than that of neat wPP. The enhancement of impact strength of the wPP/POE/SiO2 blends fabricated by ERE could be ascribed to the good dispersion of POE under elongational flow and the increase of PP crystallinity. The finding from this work provides an efficient way to recycle wPP.
Exploring the impact of interactive movement‐based anatomy learning in real classroom setting among kinesiology students
Authors: Rabattu Pierre‐Yves , Debarnot Ursula , Hoyek Nady 
Published: January 2022

AbstractDescriptive and functional anatomy is one of the most important sciences for kinesiology students. Anatomy learning requires spatial and motor imagery abilities. Learning anatomy is complex when teaching methods and instructional tools do not appropriately develop spatial and motor imagery abilities. Recent technological developments such as three‐dimensional (3D) digital tools allow to overcome those difficulties, especially when 3D tools require strong interactions with the learners. Besides interactive digital tools, embodied learning or learning in motion is an effective method for a wide variety of sciences including anatomy. The aim of this study was to explore the impact of combining movement execution with 3D animation visualization on anatomy learning in a real classroom teaching context. To do so, the results of two groups of kinesiology students during three official assessments were compared. The experimental group (n = 60) learned functional anatomy by combining movement execution with traditional knowledge acquisition (e.g., 3D animations visualization, problem‐based learning exercises). The control group (n = 61) had the same material but did not execute the movements during problem‐solving exercises. Although no differences were found between both groups on early and mid‐semester examinations, significant difference appeared at the end of the semester with an advantage for the experimental group. This exploratory study suggests that embodied learning is beneficial in improving functional anatomy learning. Therefore, it would be interesting to integrate such type of pedagogical approach within the kinesiology curriculum.
Overcoming STING Agonists Barriers: Peptide, Protein, and Biomembrane‐based Biocompatible Delivery Strategies
Authors: Zheng Yong‐Fang , Wu Jun‐Jun 
Published: January 2022

AbstractAfter development for more than ten years, stimulator of interferon genes (STING), a representative of pattern recognition receptors (PRRs), is now entering the stage of widespread applications. Along with the evolution of STING agonists of cyclic dinucleotides (CDNs) and non‐nucleotide molecules, the stability of agonists has been improved. However, their poor performance in clinical trials triggers urgent demands for highly effective delivery strategies to further improve the cellular permeability, tissue targetability and retention. In this review, we summarized the recent progress of STING agonists applications and delivery strategies with a focus on the biocompatible platforms of peptide, protein and biomembrane, providing a novel vision for the STING field and future direction.
Secure state estimation for unmanned aircraft cyber‐physical systems under multiple attacks
Authors: Feng Xiaoxue , Li Xiaoyu , Li Shuhui , Pan Feng 
Published: January 2022

AbstractBy exploiting the communication infrastructure among the sensor, actuator, and control system, attackers may compromise the security of unmanned aircraft cyber‐physical systems, with techniques such as denial‐of‐service (DoS) attack, random attack, and data‐injection attack. In this paper, the data‐injection attacks for controller and sensor are modeled as the dual unknown disturbance inputs (dual‐UIs) appearing in dynamic and measurement model. The problem of secure state estimation under multiple attacks together with the DoS attack‐induced packet dropout is transformed into the problem of stochastic system state estimation under dual‐UIs together with the missing measurement. Therefore, a recursive dual‐UIs decoupling filter is proposed through minimizing the minimum upper bound of the estimation covariance. First, a Kalman‐like recursive filter scheme independent of the dual‐UIs is established to realize the unbiased estimation. Meanwhile, a lower bounded adaptive factor is introduced to depict the state related unknown dual‐UI that cannot be eliminated completely due to the randomly missing measurements. Then, the minimum upper bound of the estimation covariance is deduced via online scalar convex optimization, based on which the measurement coefficient matrix is derived under the dual‐UIs decoupling conditions. Finally, the sufficient condition for the convergence of the proposed filter is shown and the stability of the state estimate is investigated. Simulation cases of unmanned aircraft longitudinal flight control system verifies the effectiveness and superiority of the proposed method.
Mixed performance for robust fuzzy control of nonlinear autonomous surface vehicle via T‐S model approach
Authors: Lien Chang‐Hua , Shen Chia‐Pao , Chang Hao‐Chin , Hou Yi‐You , Yu Ker‐Wei 
Published: January 2022

AbstractThis paper addresses the robust fuzzy control with mixed performance of autonomous surface vehicle (ASV) via T‐S model approach. The nonlinear model demonstrates the motion of autonomous surface vehicle. The dynamics of this model is governed by a six‐dimensional differential equation with nonlinear behavior. A robust fuzzy control is proposed to guarantee the mixed performance of uncertain T‐S fuzzy model under consideration. Linear matrix inequality (LMI) optimization approach is developed to achieve the design of controller for parallel distributed compensator (PDC) and minimization the H2 measure or H∞ performance. The mixed H2/H∞ performance can be used to achieve the disturbance attenuation and motion reduction of ASV. Finally, an example is illustrated to show the main contribution of our results. The proposed PDC is provided to guarantee the mixed performance for the nonlinear model of ASV.
A parametric experimental validation of a biorefinery concept based on anaerobic digestion of fruit and vegetable waste
Authors: Magama Primrose , Chiyanzu Idan , Mulopo Jean 
Published: January 2022

AbstractThe goal of this paper was to assess the possibilities for one‐stage reactor anaerobic digestion processing of fruit and vegetable biomass within a biorefinery concept for optimum products. Co‐digestion was the simplest strategy to implement to increase product yield among the variables tested (pH, ultrasonification, and co‐digestion). Methane yields from co‐digestion of fruit and vegetable waste (FVW) and pig manure (PM) ranged from 318 to 434 NmL /g VS, with the highest yield (434 NmL /g VS) achieved at a co‐digestion ratio of FVW75:PM25, representing a 20% increase over the methane production from FVW alone. The pH value was determined to be the most effective variable for enhancing methane production, with pH = 8 producing the maximum cumulative methane yield of 497 NmL/g VS. There was no significant change in the composition of volatile fatty acids (VFA) with pH in terms of dominant product type; valeric acid was the predominant VFA synthesized at all starting pH values except pH = 12, where formic acid was the predominant acid formed. As a digestate post‐treatment procedure, hydrothermal carbonization was combined with anaerobic digestion. At 200 °C, the maximum hydrochar yield production was 58.2%, with a higher heating value of 10.75 MJ/kg. © 2022 The Authors. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd.
High‐density lipoprotein lipid peroxidation as a diagnostics biomarker in coronary artery disease
Authors: Yazdandoust Shima , Parizadeh Seyyed Mohammad Reza , Ghayour‐Mobarhan Majid , Yaghmaei Parichehreh , Sahebkar Amir Hossein 
Published: January 2022

AbstractThis study aimed at evaluating the serum High‐density lipoprotein lipid peroxidation (HDLox) levels and their association with coronary artery disease (CAD). This case–control study comprised 572 patients with stable CAD and 281 healthy subjects with no history of cardiovascular disease (control group). Based on the results of coronary angiography, the patient group was divided into two groups: CAD− and CAD+. HDLox was measured using a fluorimetric method. The ability of HDLox and serum high‐density lipoprotein cholesterol (HDL‐C) to detect CAD and coronary artery stenosis ≥50% was also compared using the receiver operating characteristic (ROC) curve analysis. The CAD patients showed significantly higher serum HDLox levels, compared to the control group [1.15 (1.01–1.31) vs. 0.85 (0.62–1.06), no units, p < 0.001]. Moreover, serum HDLox levels were significantly lower in CAD− patients, compared to the CAD+ patients [1.05 (0.92–1.22) vs. 1.24 (1.12–1.35), no units, p < 0.001]. According to the results of univariate and multivariate logistic regression, the HDLox showed association with the presence of CAD (odds ratio [OR]: 1.754; 95% confidence interval [CI]: 1.564–1.968; p < 0.001) and coronary artery stenosis ≥50% (OR: 1.729; 95% CI: 1.534–1.949; p < 0.001). The results obtained from the area under the ROC curve revealed that the HDLox could better detect the risk of CAD and coronary artery stenosis ≥50% compared to serum HDL‐C level. The oxidation of HDL leads to a reduction in its antioxidant function and it has a crucial role in the development of atherosclerosis. HDLox is suggested as a diagnostics biomarker for CAD.
Recent research progress of biologically active peptides
Authors: Kang Linlin , Han Tingting , Cong Hailin , Yu Bing , Shen Youqing 
Published: January 2022

AbstractWith the rapid development of molecular biology and biochemical technology, great progress has been made in the study of peptides. Peptides are easy to digest and absorb, with lowering of blood pressure and cholesterol, improving immunity, regulating hormones, antibacterial, and antiviral effects. Peptides also have physiological regulation and biological metabolism functions with applications in the fields of feed production and biomedical research. In the future, the research focus of bioactive peptides will focus on their efficient preparation and application. This article introduces a comprehensive review of the types, synthesis, functionalization, and bio‐related applications of bioactive peptides. For this aim, we introduced in detail various biopeptides and then presented the production methods of bioactive peptides, such as enzymatic synthesis, microbial fermentation, chemical synthesis, and others. The applications of bioactive peptides for anticancers, immune therapy, antibacterial, and other applications have been introduced and discussed. And discussed the development prospects of biologically active peptides.
Wnt inhibitory 1 ameliorates neovascularization and attenuates photoreceptor injury in an oxygen‐induced retinopathy mouse model
Authors: Tan Wei , Xu Huizhuo , Chen Bolin , Duan Tianqi , Liu Kangcheng , Zou Jing 
Published: January 2022

AbstractRetinal neovascularization (RNV) associated diseases typically exhibit pathological neovascularization and neurodegeneration. Wnt inhibitor factor 1 (WIF1) is a secreted Wnt antagonist that regulates angiogenesis. However, the significance of WIF1 in RNV associated disease has not been explicitly tested. In our study, we found that the WIF1 expressions were strongly downregulated in the vitreous of proliferative diabetic retinopathy (PDR) and retinopathy of prematurity (ROP). Similarly, retinal WIF1 expression was significantly downregulated in OIR mice, relative to normal mice at P17. After injection of WIF1 overexpression lentivirus into the vitreous of OIR mice, overexpressing WIF1 in OIR mice vitreous strongly reduced avascular areas and neovascular tufts, increased vessel branches, raised a‐, b‐waves and oscillatory potentials amplitudes on ERG, increased retinal thickness and the number of synapses in retina, normalized the Golgi, mitochondria, and outer segments of photoreceptors. Furthermore, overexpression WIF1 suppressed expressions of β‐catenin, vascular endothelial growth factor (VEGF), p‐AKT and p‐ERK, reduced retinal reactive oxygen species (ROS) and 4‐HNE levels, improved autophagic flux, and mitigated apoptosis. In summary, WIF1 plays a key role in alleviating angiogenesis and in improving visual function in OIR mice by suppressing the Wnt/β‐catenin‐VEGF signaling pathway and ROS levels. WIF1 is an excellent candidate for targeted therapy against RNV associated diseases.
The climate resilience cycle: Using scenario analysis to inform climate‐resilient business strategies
Authors: Huiskamp Udeke , ten Brinke Bauke , Kramer Gert Jan 
Published: January 2022

AbstractClimate change affects the business environment, and companies need future‐oriented information to build climate resilience. To this end, companies are encouraged to conduct climate change scenario analysis, as recommended by the Task Force on Climate‐Related Financial Disclosures (TCFD). However, companies' actual adoption of this practice is limited as they lack a straightforward scenario analysis implementation process and relevant climate change knowledge. This research develops an implementation process by clarifying the concept of resilience into a stability and a change domain and by specifying the type of focal questions for these two domains. Next, a scenario typology guides the selection of reference scenarios, and two standard scenario methods guide the tailoring of these reference scenarios to company‐specific scenarios. By structuring this process in five steps and specifying input and process requirements, we provide an implementation process called the climate resilience cycle. By applying the cycle in transdisciplinary teams of climate change experts and company staff with knowledge about the company value chain, we bring in the required knowledge. To become climate resilient, the outcomes of the climate resilience cycle need to be integrated in the business planning and the overall company strategy. We argue that implementing the cycle as a new company routine contributes to the development of dynamic capabilities like sensing, seizing and transforming, which have been proven to be essential for integrating sustainability in company strategies. Once begun, we show how the cycle can become part of a company strategy process.
Smoothing the circular economy transition: The role of resources and capabilities enablers
Authors: Seles Bruno Michel Roman Pais , Mascarenhas Janaina , Lopes de Sousa Jabbour Ana Beatriz , Trevisan Adriana Hoffman 
Published: January 2022

AbstractA transition to the circular economy may be a solution to dissociate financial growth from negative environmental impacts. However, this transition can require an in‐depth understanding of which enablers an organization requires. This research aims to identify the enablers of the circular economy presented in the literature and analyze them against the theories about resources, capabilities, and dynamic capabilities and against the ReSOLVE framework. Through a systematic literature review, this research identified thirteen enablers grouped in three different dimensions (management and people; structure, product, and process; and relationship with stakeholders). Some enablers can be considered as resources, capabilities, or dynamic capabilities and are capable of helping firms to reach a successful transition to the circularity. They may even be sources of competitive advantage in the context of circular economy, mainly the enablers of the dimension “structure, product, and process.” The dimensions of enablers have direct and indirect links with the ReSOLVE framework action areas. Through the discussions of some real cases, it was possible to exemplify how some enablers lead companies to circularity. Besides that, this research posits seven research gaps for future studies.
Responsiveness and other psychometric properties of the Yale–Brown Obsessive–Compulsive Scale Severity Scale—Second Edition in a Dutch clinical sample
Authors: Alić Mediha , de Leeuw Aart , Selier Jonathan , van Megen Harold , Visser Henny 
Published: January 2022

AbstractThe Yale–Brown Obsessive–Compulsive Scale (Y‐BOCS) is a widely used clinician‐rated interview to assess the presence and severity of obsessive–compulsive disorder (OCD). The scale is revised (Y‐BOCS‐II) to overcome several psychometric limitations, for example by extending the scoring for better discrimination within higher severity levels. The aim of the present study was to examine the responsiveness and other psychometric properties of the Y‐BOCS‐II Severity Scale in a Dutch clinical sample. The Y‐BOCS‐II is translated into Dutch and administered to 110 patients seeking therapy for OCD. This was done twice, before and after treatment. The original Y‐BOCS was simultaneously rated. Self‐report measures regarding depression, symptom severity and OCD symptoms were assessed. The Y‐BOCS‐II has a good internal consistency (Cronbach's α = 0.84), test–retest (intraclass correlation coefficient [ICC] = 0.89) and interrater reliability (ICC = 0.98). The construct validity proved to be modest to good. The responsiveness over time was in favour of the Y‐BOCS‐II, compared with the Y‐BOCS‐I, particularly in the moderate–severely affected OCD patients. The Y‐BOCS‐II Severity Scale is a reliable and valid instrument for accurately assessing the severity of OCD symptoms and for measuring treatment‐induced change. This second version also has clinical and psychometric advantages over the Y‐BOCS‐I. When these findings are sufficiently replicated, use of the Y‐BOCS‐II as the new common standard seems recommendable.
Molecular Mechanism of the Mononuclear Copper Complex‐Catalyzed Water Oxidation from Cluster‐Continuum Model Calculations
Authors: Wu Peng , Yan Shengheng , Fang Wenhan , Wang Binju 
Published: January 2022

AbstractCluster‐continuum model calculations were conducted to decipher the mechanism of water oxidation catalyzed by a mononuclear copper complex. Among various O−O bond formation mechanisms investigated in this study, the most favorable pathway involved the nucleophilic attack of OH− onto the .+L−CuII−OH− intermediate. During such process, the initial binding of OH− to the proximity of .+L−CuII−OH− would result in the spontaneous oxidation of OH−, leading to OH⋅ radical and CuII−OH− species. The further O−O coupling between OH⋅ radical and CuII−OH− was associated with a barrier of 14.8 kcal mol−1, leading to the formation of H2O2 intermediate. Notably, the formation of “CuIII−O.−” species, a widely proposed active species for O−O bond formation, was found to be thermodynamically unfavorable and could be bypassed during the catalytic reactions. On the basis the present calculations, a catalytic cycle of the mononuclear copper complex‐catalyzed water oxidation was proposed.
Have we addressed internationalization sufficiently? Investigating British and Sino‐British postgraduate curricula with a postcolonial design perspective
Authors: Wang Qian , Gooden Amy , Gu Haibo , Ma Hanlihui , Pan Yuchen 
Published: January 2022

AbstractUsing the Internationalization of the Curriculum (IoC) model, this study analyses postgraduate educational programmes that contribute to internationalization in higher education at British and Sino‐British transnational universities. The purpose is to explore postcolonial curricular design influences and opportunities. The study identified patterns based on content analysis of twelve programmes' goals, approaches, and course listings. The findings reflected noteworthy similarities with limited emphasis on the emerging paradigmatic shift of IoC. The study invited one programme director from each type of university to speak about the design intentions from an insider's perspective. The discovery was that both types of universities were driven, in part, by a response to global market trends rather than an ideological postcolonial design imperative. Semi‐structured interviews of postgraduate Chinese students in the Sino‐British university's programme were conducted to understand students' perceptions of learning and former pedagogical experiences. Students appreciated opportunities to explore indigenous knowledge and experiences to make the curriculum relevant and meaningful. They expressed a clear need to conduct independent discoveries without necessarily following the patterns established by Western scholars. The paper offers suggestions for constructing postcolonial learning environments. Implications for educational practices are discussed.