bluuebunny/crossref_metadata_2025_split huggingface dataset:
Landscape‐scale habitat fragmentation is positively related to biodiversity, despite patch‐scale ecosystem decay
Authors: Riva Federico , Fahrig Lenore 
Published: December 2022

AbstractPositive effects of habitat patch size on biodiversity are often extrapolated to infer negative effects of habitat fragmentation on biodiversity at landscape scales. However, such cross‐scale extrapolations typically fail. A recent, landmark, patch‐scale analysis (Chase et al., 2020, Nature 584, 238–243) demonstrates positive patch size effects on biodiversity, that is, ‘ecosystem decay’ in small patches. Other authors have already extrapolated this result to infer negative fragmentation effects, that is, higher biodiversity in a few large than many small patches of the same cumulative habitat area. We test whether this extrapolation is valid. We find that landscape‐scale patterns are opposite to their analogous patch‐scale patterns: for sets of patches with equal total habitat area, species richness and evenness decrease with increasing mean size of the patches comprising that area, even when considering only species of conservation concern. Preserving small habitat patches will, therefore, be key to sustain biodiversity amidst ongoing environmental crises.
Combining modified hyper learning binary dragonfly algorithm and deep learning for BI‐RADS classification of breast masses in mammograms
Authors: Khanna Priyanka , Sahu Mridu , Singh Bikesh Kumar , Bhateja Vikrant 
Published: December 2022

AbstractBackgroundIt has always been difficult and challenging to quantify the breast imaging reporting and data system (BI‐RADS) criteria into several categories. Automatic quantitation can assist clinicians in the early diagnosis and treatment eventually reducing the mortality rate. As a result, in the recent years, early BC diagnosis methods based on pathological breast images have been in high demand.MethodWe propose a computer‐aided diagnosis (CAD) system that combines the transfer learning approach with meta‐heuristic optimization, and machine learning to classify BI‐RADS breast masses categories within levels 3 and 4. Transfer learning technique ResNet‐18 is used for high‐level feature extraction. The clinically important features are then chosen using a modified feature selection technique based on the Hyper Learning Binary DragonFly Algorithm (M‐HLBDA). Finally, a Fine K‐nearest neighbour (KNN) is employed for classification.ResultA series of mammography breast mass images from the curated breast imaging subset of DDSM (CBIS‐DDSM) are evaluated in order to categorize within BI‐RADS levels 3 and 4. Experimental findings demonstrated M‐HLBDA capability to identify the optimal feature subset, which minimizes the number of selected features and maximizes the classification. Our system attained classification accuracy of 87.5%, Sensitivity of 88.8%, Specificity of 86.5%, and AUC of 0.82 using KNN on selected features using M‐HLBDA.ConclusionOur model can annotate and classify BI‐RADS levels 3 and 4 with better classification accuracy, and it may be used as an automated system to help radiologists.
Fisheries Oceanography: The first 30 years and new challenges in the 21st century
Authors: Bograd Steven J. , Edwards Martin , Ito Shin‐ichi , Nye Janet , Chappell Emily 
Published: December 2022

AbstractThe journal Fisheries Oceanography provides a global forum for fisheries scientists and oceanographers to understand how marine ecosystems, and the services they provide to society, are structured and shaped by environmental variability and climate change. With this special issue, as well as the 30th Anniversary Virtual Issue of the most influential papers from the journal's history, we commemorate 30 years of publishing leading research in the field of fisheries oceanography. These issues showcase the extent, depth and impact of the research published in Fisheries Oceanography. We also reflect on the evolution of research themes through the journal's history, and highlight key emergent themes in our field. We look forward to continuing to publish impactful research in the pages of Fisheries Oceanography in the years ahead.
Datasets for the reporting of primary tumour in bone: recommendations from the International Collaboration on Cancer Reporting (ICCR)
Authors: Bovée Judith V M G , Webster Fleur , Amary Fernanda , Baumhoer Daniel , Bloem J L (Hans) , Bridge Julia A , Cates Justin M M , de Alava Enrique , Dei Tos Angelo Paolo , Jones Kevin B , Mahar Annabelle , Nielsen G Petur , Righi Alberto , Wagner Andrew J , Yoshida Akihiko , Fletcher Christopher D M 
Published: December 2022

Background and objectivesBone tumours are relatively rare and, as a consequence, treatment in a centre with expertise is required. Current treatment guidelines also recommend review by a specialised pathologist. Here we report on international consensus‐based datasets for the pathology reporting of biopsy and resection specimens of bone sarcomas. The datasets were produced under the auspices of the International Collaboration on Cancer Reporting (ICCR), a global alliance of major (inter‐)national pathology and cancer organisations.Methods and resultsAccording to the ICCR's process for dataset development, an international expert panel consisting of pathologists, an oncologic orthopaedic surgeon, a medical oncologist, and a radiologist produced a set of core and noncore data items for biopsy and resection specimens based on a critical review and discussion of current evidence. All professionals involved were bone tumour experts affiliated with tertiary referral centres. Commentary was provided for each data item to explain the rationale for selecting it as a core or noncore element, its clinical relevance, and to highlight potential areas of disagreement or lack of evidence, in which case a consensus position was formulated. Following international public consultation, the documents were finalised and ratified, and the datasets, including a synoptic reporting guide, were published on the ICCR website.ConclusionThese first international datasets for bone sarcomas are intended to promote high‐quality, standardised pathology reporting. Their widespread adoption will improve the consistency of reporting, facilitate multidisciplinary communication, and enhance comparability of data, all of which will help to improve management of bone sarcoma patients.
Elevated pan traps optimise the sampling of bees, including when the availability of floral resources is high
Authors: Chamorro Fermín J. , Faria Christiana M. A. , Araújo Francisca S. , Freitas Breno M. 
Published: December 2022

Abstract
To sample bee communities, a combination of methods is necessary, the most common being hand netting (HN) and pan traps (PT). However, there has been little exploration into how vertical distribution of PT can improve their sampling efficiency, also taking the temporal variation of floral resources into account.
Here, we analysed the properties of bee communities sampled with PT at different heights (1.6 and 4.0 m) compared with PTs close to the ground, HN and large blue bucket trap (BB). In addition, we tested the effect of variation in the availability of floral resources on the performance of each method. Bees were collected in fragments of the Brazilian Caatinga.
We captured 60 bee species with PTs, HN and BB, with significant increases in the sample coverage with elevated bowls (BB = 56.7%, HN = 60.0%, PT0.3 m = 23.3%, PT1.6 m = 36.7%, PT4.0 m = 50.0%). Elevating the bowls increased the sampling of bees with larger body size. Considering the three heights, PTs registered similar richness compared to HN and BB, but differed in the composition of species and ecological traits.
When floral resource availability was greater, the abundance and richness of bees caught in PTs decreased, however, the elevated PT increased their ecological uniqueness (degree of uniqueness of the samples in terms of community composition). Thus, elevating PTs enables the capture of bees that forage at a specific height when floral resources increase.
Our results highlight the importance of the vertical distribution of PT for sampling bees, since it improves their performance and its complementarity with other methods.
Long‐pulsed Nd: YAG laser (1064 nm) versus intralesional botulinum toxin type (A) in acne vulgaris therapy: a split face study
Authors: Ibrahim Asia Mohammed , Omar Ghada Abdel Badea , Hamdino Mervat 
Published: December 2022

AbstractBackgroundAcne can be considered more than a cosmetic concern due to its large impact on patients' quality of life. There are various therapeutic options for inflammatory acne, but inconvenience and undesirable side effects prompted a search for more acceptable treatments. This study aimed to compare the clinical efficacy and safety of long‐pulsed Nd: YAG laser 1064 nm versus intralesional botulinum toxin type‐A (BTX‐A) in inflammatory acne therapy.MethodsA prospective randomized split‐face comparative study involved 30 patients with inflammatory acne. Each patient received long‐pulsed Nd: YAG 1064 nm laser on one side, and intralesional BTX‐A on the other side, monthly until improvement or maximum three sessions. Cases were assessed by acne lesions counting and grading of severity by Investigator's Global Assessment of acne (IGAs) at baseline, each session, and after 3 months follow‐up.ResultsA highly statistically significant improvement in lesions count and IGAs for both sides was observed, with statistically non‐significant difference between both sides at end of treatment sessions. While, after 3 months follow‐up, there was a more significant improvement at laser side.ConclusionBoth long‐pulsed Nd: YAG laser 1064 nm and intralesional BTX‐A are safe and effective for acne therapy. Nd‐YAG laser has a more prolonged efficacy and lower recurrence rate than intralesional BTX‐A.
Multiple breast cancer liver metastases response to macrophage‐delivered nanotherapy evaluated via a 3D continuum model
Authors: Goodin Dylan A. , Chau Eric , Tiwari Anjana , Godin Biana , Frieboes Hermann B. 
Published: December 2022

AbstractBreast cancer liver metastases (BCLM) are usually unresectable and difficult to treat with systemic chemotherapy. A major reason for chemotherapy failure is that BCLM are typically small, avascular nodules, with poor transport and fast washout of therapeutics from surrounding capillaries. We have previously shown that nanoalbumin‐bound paclitaxel (nab‐PTX) encapsulated in porous silicon multistage nanovectors (MSV) is preferentially taken up by tumour‐associated macrophages (TAM) in the BCLM microenvironment. The TAM alter therapeutic transport characteristics and retain it in the tumour vicinity, increasing cytotoxicity. Computational modeling has shown that therapeutic regimens could be designed to eliminate single lesions. To evaluate clinically‐relevant scenarios, this study develops a modeling framework to evaluate MSV‐nab‐PTX therapy targeting multiple BCLM. An experimental model of BCLM, splenic injection of breast cancer 4 T1 cells was established in BALB/C mice. Livers were analyzed histologically to determine size and density of BCLM. The data were used to calibrate a 3D continuum mixture model solved via distributed computing to enable simulation of multiple BCLM. Overall tumour burden was analyzed as a function of metastases number and potential therapeutic regimens. The computational model enables realistic 3D representation of metastatic tumour burden in the liver, with the capability to evaluate BCLM growth and therapy response for hundreds of lesions. With the given parameter set, the model projects that repeated MSV‐nab‐PTX treatment in intervals <7 days would control the tumour burden. We conclude that nanotherapy targeting TAM associated with BCLM may be evaluated and fine‐tuned via 3D computational modeling that realistically simulates multiple metastases.
Insect seed and cone predation reduces reproductive potential of treeline conifers across northern Canada
Authors: Brehaut Lucas , Goodwin Katie J. A. , Reid Kirsten A. , Crofts Anna L. , Danby Ryan K. , Mamet Steven D. , Brown Carissa D. 
Published: December 2022

AbstractAimAltitudinal and latitudinal treeline ecotones have not consistently responded to climate warming in the direction and/or magnitude predicted by climate alone, suggesting that non‐climatic mechanisms (e.g. biotic interactions) also mediate treeline range dynamics. Through a collaborative research approach, we assessed environmental conditions associated with pre‐dispersal insect cone granivory and how this biotic interaction may govern the reproductive potential, and therefore range dynamics, of spruce‐dominated treelines across northern Canada.LocationIn all, 10 boreal forest treelines, tundra and alpine, from Yukon to Newfoundland and Labrador, Canada.TaxaWhite spruce (Picea glauca[Moench] Voss), Black spruce (Picea mariana[Mill.] B.S.P.),Strobilomyiaspp.,Megastigmusspp.MethodsTreeline sites were assessed for presence and magnitude of pre‐dispersal seed granivory by insects along with viable seed availability. We quantified stand density metrics, organic layer depth and understorey vegetation composition at each location and, subsequently, incorporated those variables into generalized linear mixed models to establish predictors of granivory magnitude and viability of available seed.ResultsInsect granivory was widespread across sites; however, site‐specific patterns of granivory were associated with increased moss cover and decreased shrub cover and stand density. While all black spruce‐dominated sites exhibited seed viability rates > 50%, the number of seeds produced per cone varied, suggesting that within‐site abiotic conditions and biotic interaction pressures limit successful colonization of novel environments in advance of seed dispersal.Main ConclusionsThe modelled relationships between granivory, seed viability and environmental conditions represent an essential step towards generalizing how and when biotic interactions across subarctic treelines influence boreal tree range dynamics before seed dispersal. Connections between granivory magnitude and site‐level treeline characteristics (e.g. stand density, understorey vegetation) will provide a more comprehensive understanding of treeline range dynamics under continued climate change.
Analyzing factors contributing to COVID‐19 mortality in the United States using artificial intelligence techniques
Authors: Tanhaeean Mehrab , Nazari Negin , Iranmanesh Seyed Hosein , Abdollahzade Majid 
Published: December 2022

AbstractHaving started since late 2019, COVID‐19 has spread through far many nations around the globe. Not being known profoundly, the novel virus of the Coronaviruses family has already caused more than half a million deaths and put the lives of many more people in danger. Policymakers have implemented preventive measures to curb the outbreak of the virus, and health practitioners along with epidemiologists have pointed out many social and hygienic factors associated with the virus incidence and mortality. However, a clearer vision of how the various factors cited hitherto can affect total death in different communities is yet to be analyzed. This study has put this issue forward. Applying artificial intelligence techniques, the relationship between COVID‐19 death toll and determinants mentioned as strongly influential in earlier studies was investigated. In the first stage, employing Best‐Worst Method, the weight of the primer contributing factor, effectiveness of strategies, was estimated. Then, using an integrated Best‐Worst Method–local linear neuro‐fuzzy–adaptive neuro‐fuzzy inference system approach, the relationship between COVID‐19 mortality rate and all factors namely effectiveness of strategies, age pyramid, health system status, and community health status was elucidated more specifically.
Trends and rhythms in carbonatites and kimberlites reflect thermo-tectonic evolution of Earth
Authors: Liu Shuang-Liang , Ma Lin , Zou Xinyu , Fang Linru , Qin Ben , Melnik Aleksey E. , Kirscher Uwe , Yang Kui-Feng , Fan Hong-Rui , Mitchell Ross N. 
Published: December 2022

Abstract
Earth's thermo-tectonic evolution determines the way the planet's interior and surface interact and shows temporal changes in both trends and periodic rhythms. By sampling the subcontinental lithospheric mantle that represents the interface between the convecting mantle and the crust, carbonatite and kimberlite should be ideal rock types for documenting this evolution. The first-order secular rise of kimberlites over time has been noted by researchers, but there is much debate over how to interpret this trend, and their second-order variability has received less attention. We compiled a comprehensive global carbonatite database and compared it with an existing kimberlite one. We find that the numbers of carbonatites and kimberlites have similar increasing secular trends, with accelerated growth after ca. 1 Ga, and show the same periodic rhythms that have been synchronized to the supercontinent cycle since ca. 2.1 Ga. We link these trends and rhythms to the long-term change of Earth and the supercontinent cycle, both of which have altered the temperature of, and the subduction-recycled volatile flux into, the subcontinental lithosphere. Such consistent records in carbonatite and kimberlite behavior provide critical evidence for the synchronous thermo-tectonic evolution of the entire subcontinental lithosphere.
Development of89Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration
Authors: Kol Arjan , Fan Xiaoyu , Wazynska Marta A. , van Duijnhoven Sander M.J. , Giesen Danique , Plat Annechien , Van Eenennaam Hans , Elsinga Philip H. , Nijman Hans W. , de Bruyn Marco 
Published: December 2022

PurposeCD103, an integrin specifically expressed on the surface of cancer-reactive T cells, is significantly increased during successful immunotherapy across human malignancies. In this study, we describe the generation and zirconium-89 (89Zr) radiolabeling of monoclonal antibody (mAb) clones that specifically recognize human CD103 for non-invasive immune positron-emission tomography (PET) imaging of T cell infiltration as potential biomarker for effective anticancer immune responses.Experimental designFirst, to determine the feasibility of anti-CD103 immuno-PET to visualize CD103-positive cells at physiologically and clinically relevant target densities, we developed an89Zr-anti-murine CD103 PET tracer. Healthy, non-tumor bearing C57BL/6 mice underwent serial PET imaging after intravenous injection, followed by ex vivo biodistribution. Tracer specificity and macroscopic tissue distribution were studied using autoradiography combined with CD103 immunohistochemistry. Next, we generated and screened six unique mAbs that specifically target human CD103 positive cells. Optimal candidates were selected for89Zr-anti-human CD103 PET development. Nude mice (BALB/cOlaHsd-Foxn1nu) with established CD103 expressing Chinese hamster ovary (CHO) or CHO wild-type xenografts were injected with89Zr-anti-human CD103 mAbs and underwent serial PET imaging, followed by ex vivo biodistribution.Results89Zr-anti-murine CD103 PET imaging identified CD103-positive tissues at clinically relevant target densities. For human anti-human CD103 PET development two clones were selected based on strong binding to the CD103+CD8+T cell subpopulation in ovarian cancer tumor digests, non-overlapping binding epitopes and differential CD103 blocking properties. In vivo, both89Zr-anti-human CD103 tracers showed high target-to-background ratios, high target site selectivity and a high sensitivity in human CD103 positive xenografts.ConclusionCD103 immuno-PET tracers visualize CD103 T cells at relevant densities and are suitable for future non-invasive assessment of cancer reactive T cell infiltration.
Categorizations of Limits of Grothendieck Groups over a Frobenius P-Category
Authors: Puig Lluis 
Published: December 2022

In [Frobenius Categories Versus Brauer Blocks, Progress in Math., 274] and in [Ordinary Grothendieck groups of a Frobenius [Formula: see text]-category, Algebra Colloq. 18 (2011) 1–76], we consider suitable inverse limits of Grothendieck groups of categories of modules in characteristics [Formula: see text] and zero, obtained from a folded Frobenius [Formula: see text]-category[Formula: see text], which covers the case of the Frobenius[Formula: see text]-categories associated with blocks; moreover, in [Beyond a question of Markus Linckelmann, arxiv.org/abs/1507.04278] we show that a folded Frobenius [Formula: see text]-categoryis actually equivalent to the choice of a regular central [Formula: see text]-extension [Formula: see text] of [Formula: see text]. Here, taking advantage of the existence of a perfect [Formula: see text] -locality [Formula: see text], we exhibit those inverse limits as the true Grothendieck groups of the categories of [Formula: see text]-and [Formula: see text]-modules for a suitable [Formula: see text]-group [Formula: see text] associated to the [Formula: see text]-category [Formula: see text] obtained from [Formula: see text] and [Formula: see text]. It depends on a vanishing cohomology result, given with more generality in the Appendix.
Development Communication and Extension: The Case of a Premier State University in CALABARZON, Philippines
Authors: Medina Benedict 
Published: December 2022

Development communication is realized in extension, and extension activities are also DevCom in nature. This study aimed to describe and narrate that development communication is practiced and realized through extension in Batangas State University – The Philippines’ National Engineering University, CALABARZON, Philippines. This study utilized the descriptive-narrative research design in a qualitative approach. Various literature of the Extension Service Office and DevCom of BatStateU were collected to answer the research objectives. Interview-conversations were also conducted among university extension officials and development communication faculty. It was found out that BatStateU has a rich historical development up to what it is now as The National Engineering University. It offers 12 extension agenda plus 1 - to be approved by the University Board of Regents. And lastly, values and concepts that comprised development communication based from Quebral’s definition in 2012 were embodied in the practice of extension in BatStateU.
Na trilha dos impressos: subversão e resistência
Authors: Endo Ana Claudia Braun 
Published: December 2022

Em tempos em que a polarização política separa multidões e eleições aproximam-se, parece oportuno revisitar parte da história sociopolítica da nação brasileira para trazer à luz os desmandos que um Governo envolvo em autoritarismo pode causar. “Impressos subversivos - arte, cultura e política no Brasil 1924-1964”, da historiadora Maria Luiza Tucci Carneiro, do Departamento de História da Faculdade de Filosofia, Letras e Ciências Humanas (FFLCH) da Universidade de São Paulo (USP), organiza este compêndio a partir de materiais impressos considerados subversivos em um sistema de conflitos entre Estado e artistas, intelectuais, estudantes e todos aqueles que ousavam se rebelar contra o poderio do sistema político instituído no período e, assim, foram rotulados como anarquistas, comunistas, marxistas.