bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanical strain stimulates COPII‐dependent secretory trafficking via Rac1
Authors: Phuyal Santosh , Djaerff Elena , Le Roux Anabel‐Lise , Baker Martin J , Fankhauser Daniela , Mahdizadeh Sayyed Jalil , Reiterer Veronika , Parizadeh Amirabbas , Felder Edward , Kahlhofer Jennifer C , Teis David , Kazanietz Marcelo G , Geley Stephan , Eriksson Leif , Roca‐Cusachs Pere , Farhan Hesso 
Published: August 2022

AbstractCells are constantly exposed to various chemical and physical stimuli. While much has been learned about the biochemical factors that regulate secretory trafficking from the endoplasmic reticulum (ER), much less is known about whether and how this trafficking is subject to regulation by mechanical signals. Here, we show that subjecting cells to mechanical strain both induces the formation of ER exit sites (ERES) and accelerates ER‐to‐Golgi trafficking. We found that cells with impaired ERES function were less capable of expanding their surface area when placed under mechanical stress and were more prone to develop plasma membrane defects when subjected to stretching. Thus, coupling of ERES function to mechanotransduction appears to confer resistance of cells to mechanical stress. Furthermore, we show that the coupling of mechanotransduction to ERES formation was mediated via a previously unappreciated ER‐localized pool of the small GTPase Rac1. Mechanistically, we show that Rac1 interacts with the small GTPase Sar1 to drive budding of COPII carriers and stimulates ER‐to‐Golgi transport. This interaction therefore represents an unprecedented link between mechanical strain and export from the ER.
Neonatal Outcomes of Mothers With a Disability
Authors: Brown Hilary K. , Chen Simon , Guttmann Astrid , Havercamp Susan M. , Parish Susan L. , Ray Joel G. , Vigod Simone N. , Tarasoff Lesley A. , Lunsky Yona 
Published: August 2022

OBJECTIVES
To assess the risk of neonatal complications among women with a disability.

METHODS
This population-based cohort study comprised all hospital singleton livebirths in Ontario, Canada from 2003 to 2018. Newborns of women with a physical (N = 144 187), sensory (N = 44 988), intellectual or developmental (N = 2207), or ≥2 disabilities (N = 8823) were each compared with 1 593 354 newborns of women without a disability. Outcomes were preterm birth &lt;37 and &lt;34 weeks, small for gestational age birth weight (SGA), large for gestational age birth weight, neonatal morbidity, and mortality, neonatal abstinence syndrome (NAS), and NICU admission. Relative risks were adjusted for social, health, and health care characteristics.

RESULTS
Risks for neonatal complications were elevated among newborns of women with disabilities compared with those without disabilities. Adjusted relative risks were especially high for newborns of women with an intellectual or developmental disability, including preterm birth &lt;37 weeks (1.37, 95% confidence interval 1.19–1.58), SGA (1.37, 1.24–1.59), neonatal morbidity (1.42, 1.27–1.60), NAS (1.53, 1.12–2.08), and NICU admission (1.53, 1.40–1.67). The same was seen for newborns of women with ≥2 disabilities, including preterm birth &lt;37 weeks (1.48, 1.39–1.59), SGA (1.13, 1.07–1.20), neonatal morbidity (1.28, 1.20–1.36), NAS (1.87, 1.57–2.23), and NICU admission (1.35, 1.29–1.42).

CONCLUSIONS
There is a mild to moderate elevated risk for complications among newborns of women with disabilities. These women may need adapted and enhanced preconception and prenatal care, and their newborns may require extra support after birth.
Effect of using crushed glass on shear strength parameters of poorly graded sand
Authors: Sheer Ali Tawfek , Salman Nassr , Fakhraldin Mohammed K. 
Published: August 2022

Abstract
This paper presents an experimental work of using crushed glass mixed with the poorly graded sandy soil to investigate the possibility of shear strength parameters improvement using the direct shear test. The crushed glass is sieved and prepared for seven sets of percentages, the collected percentages of crushed glass represented a mix of glass retained on sieves No. 4, No. 8, No. 30, No. 100, and No. 200 and were added as a weight ratio of the sample for many cases. The main results of this work show that the mixing 10% of crushed glass for sieves No. 8, No. 200, and No. 50 increase the angle of internal friction of poorly graded sand (Ø˚) about 15%, 3%, and 29% respectively, and mixing 10% of crushed glass retained on sieve No. 4 decrease Ø˚ about 40%.
A novel adaptive restarting genetic algorithm based congestion management
Authors: Gajjala Madhu Mohan , Ahmad Aijaz 
Published: August 2022

AbstractThis manuscript proposes a novel adaptive restarting genetic algorithm-based solution approach for rescheduling generation-based congestion control. The generator sensitivity values are considered to select generators to participate in the congestion management. The efficacy of the suggested technique is demonstrated on a 39-bus New England system and a modified IEEE 30 bus system, and a comparative study with other optimization strategies are established. The findings produced with the suggested technique for congestion management better the outcomes obtained with different methods. The presented approach ensures a superior convergence profile by eliminating local minima traps. This method also assists the independent system operator in managing congestion more efficiently.
Awareness of polycystic ovary syndrome (PCOS) among medical students— A multi-centric cross-sectional survey in West Bengal
Authors: Ghosh Abantika , Dutta Soham , Ghosh Trishan 
Published: August 2022

To evaluate the awareness of Poly Cystic Ovary syndrome (PCOS) among medical students of different medical colleges in West Bengal.: Open label, cross-sectional, multi-centric study was done amongst MBBS students of different medical colleges in west Bengal. An online questionnaire was prepared whose link was shared through social media. The portal was kept open for 7 days during which the students were allowed to submit their entries. Only one entry per student was allowed. Use of any reference like books and internet was not allowed. Data was analysed at Department of Obstetrics & Gynecology of R.G. Kar Medical College. P value &#60;0.05 was considered significant. A total of 148 students participated in the study of whom 107 were females (72.29%) and 41 males (27.70%). The highest number of responses was from College of Medicine and JNM hospital, Kalyani, Nadia (47.29%). Most of the respondents were females (72.20%). Females had a better knowledge about the signs and symptoms of PCOS. The awareness amongst the medical students about Hirsutism (p value 0.01), facial acne (p value 0.02) and Diabetes (p value 0.02) as symptoms of PCOS were statistically significant (p value&#60;0.05). That diabetes is a possible complication of PCOS was known to 44.85% females and 63.41% males and the result was statistically significant (p value 0.02). Females were more aware of the role of lifestyle modification to alleviate symptoms of PCOS. Awareness about doing exercise (p value 0.0003), losing weight (p value 0.02) and increased intake of fruits and vegetables (p value 0.007) as curative measures of PCOS were statistically significant. PCOS is an inherited disorder was known to 14.01% females and 26.82% males and the result was statistically significant (p value 0.01). Change in ovarian morphology occurring in PCOS was known to 53.27% females and 58.53% males but the result was statistically insignificant (p value 0.8). Although, majority of students have the basic knowledge of PCOS, but periodic academic activities (Seminars, CME etc) are required to upgrade the information about symptoms and awareness of PCOS.
HUBUNGAN AGAMA ISLAM DAN PEMBANGUNAN EKONOMI DALAM KEMAJUAN NEGARA: SEBUAH TINJAUAN UMUM
Authors: Ilahi Restu Prana , Ramdhani Indra , Yusuf Muhamad , Witro Doli 
Published: August 2022

Abstract:This article discusses the relationship between religion and economic development. Both have in common in achieving a goal, namely the creation of prosperity in human life. It was initiated by the findings of Weber, who observed the behavior of Catholics and Protestants who have differences in carrying out their lives. Protestants who take advantage of the economic side in their lives make them superior to Catholics. So that an initiative emerged to carry out church reform based on the arbitrariness of the Catholic church in carrying out rites that were more used for personal interests. Through a set of rules, Islam allows and even encourages a Muslim to carry out development, especially economic development. Because as a caliph on this earth, humans are obliged to take care of, preserve, and maintain various things in this universe, and it is forbidden to destroy them. In Islamic teachings, five points form the basis of human life to achieve prosperity, namely religion (ad-din), soul (an-nafs), reason (al-aql), offspring (nasb), and property (mal). Economic development in the Islamic point of view is raised, one of which is to achieve prosperity through these five main elements. So, in this case, religion has a close relationship with aspects of economic development, as can be seen from the similarities between the two in achieving the welfare of human life.Abstrak: Artikel ini membahas hubungan antara agama dan pembangunan ekonomi. Keduanya memiliki kesamaan dalam mencapai suatu tujuan, yaitu terciptanya kesejahteraan dalam kehidupan manusia. Hal ini diawali dengan temuan Weber yang mengamati perilaku umat Katolik dan Protestan yang memiliki perbedaan dalam menjalankan kehidupannya. Orang Protestan yang memanfaatkan sisi ekonomi dalam hidupnya menjadikan mereka lebih unggul dari Katolik. Sehingga muncul inisiatif untuk melakukan reformasi gereja berdasarkan kesewenang-wenangan gereja Katolik dalam menjalankan ritus-ritus yang lebih banyak digunakan untuk kepentingan pribadi. Melalui seperangkat aturan, Islam membolehkan bahkan mendorong seorang muslim untuk melakukan pembangunan, khususnya pembangunan ekonomi. Karena sebagai khalifah di muka bumi ini, manusia wajib menjaga, memelihara, dan memelihara berbagai hal yang ada di alam semesta ini, dan dilarang untuk dimusnahkan. Dalam ajaran Islam, lima hal yang menjadi landasan hidup manusia untuk mencapai kesejahteraan, yaitu agama (ad-din), jiwa (an-nafs), akal (al-aql), keturunan (nasb), dan harta (mal). Pembangunan ekonomi dalam pandangan Islam dimunculkan, salah satunya untuk mencapai kesejahteraan melalui lima unsur utama tersebut. Jadi, dalam hal ini agama memiliki hubungan yang erat dengan aspek pembangunan ekonomi, terlihat dari persamaan keduanya dalam mencapai kesejahteraan hidup manusia.
KARAKTER RELIGIUS DALAM BUDAYA KELAHIRAN MASYARAKAT BANJAR KALIMANTAN SELATAN
Authors: Jannah Raudatul 
Published: August 2022

Abstract: This study aims to describe the people of Banjar South Kalimantan who have a variety of cultures that still have a strong emotional connection with the old culture left by their ancestors. Beliefs that are deeply rooted in the community make some rituals in culture mandatory to be carried out under customary law. The influence of old beliefs gave its color to the culture of the Banjar people who later acculturated and collaborated with Islam. The steps taken in data collection in this study include sorting, organizing, and editing. After all the desired data is collected, data analysis is carried out with interpretation. The results of this study show that Islamic teachings are very in line with the diversity that exists in society. The religious character of Islam gives a new color to the old culture of society which contains values that are important to be applied to all lines of social life. The number of foreign cultures that tend to damage can more or less be countered by strengthening religious character through the culture that exists and develops in the community as in the birth culture of the Banjar people of South Kalimantan.Keywords: Religious character, birth culture, Banjar people. Abstrak: Penelitian ini bertujuan untuk mendeskripsikan kehidupan masyarakat Banjar Kalimantan Selatan yang memiliki beragam kebudayaan yang masih memiliki hubungan emosional yang kuat dengan kebudayaan lama peninggalan nenek moyang. Keyakinan yang mengakar kuat dalam diri masyarakat membuat beberapa ritual dalam kebudayaan menjadi wajib dilaksanakan secara hukum adat. Pengaruh keyakinan lama memberikan warna tersendiri pada kebudayaan masyarakat Banjar yang kemudian berakulturasi dan berakomodasi dengan Islam. Langkah-langkah yang ditempuh dalam pengumpulan data pada penelitian ini meliputi penyortiran, pengorganisasian, dan penyuntingan. Selanjutnya setelah semua data yang dikehendaki terkumpul dilakukan analisis data dengan interpretasi. Hasil penelitian ini menunjukkan bahwa ajaran Islam sangat berkesesuaian dengan keberagaman yang ada di masyarakat. Karakter religius Islam memberikan warna baru terhadap kebudayaan lama masyarakat yang di dalamnya mengandung nilai-nilai yang penting untuk diaplikasikan pada seluruh lini kehidupan bermasyarakat. Banyaknya budaya asing yang cenderung merusak sedikit banyak dapat ditangkis dengan penguatan karakter religius melalui budaya yang ada dan berkembang di masyarakat seperti dalam budaya kelahiran pada masyarakat Banjar Kalimantan Selatan. Kata Kunci: Karakter religius, budaya kelahiran, masyarakat Banjar.
PENGARUH PELAKSANAAN MODEL PEMBELAJARAN BRAIN BASED LEARNING TERHADAP AKTIVITAS BELAJAR SISWA KELAS V MATA PELAJARAN IPA DI MIN 2 PALEMBANG
Authors: Mustopa Mustopa , Badaruddin Badaruddin 
Published: August 2022

Judul penelitian ini adalah Pengaruh Penerapan Model Pembelajaran Brain Based Learning Terhadap Aktivitas Belajar Siswa Kelas V Mata Pelajaran IPA di MIN 2 Palembang. Peneliti mengangkat judul tersebut dikarenakan pelaksanaan pembelajaran IPA di MIN 2 Palembang selama ini memiliki banyak kelemahan antara lain, proses pembelajaran IPA masih kurang melibatkan siswa pada aktivitas keterampilan proses atau kerja ilmiah IPA, terbatasnya alat – alat praktikum dan waktu yang dimiliki guru.Rumusan masalah dalam penelitian ini adalah bagaimana penerapan model pembelajaran brain based learning pada Mata Pelajaran IPA, bagaimanaaktivitas belajar siswa kelas V Mata Pelajaran IPA, dan apakah adapengaruh penerapan model pembelajaran brain based learning terhadap aktivitas belajar siswa kelas V Mata Pelajaran IPA di MIN 2 Palembang.Untuk menganalisa data dalam penelitian ini maka penulis menggunakan teknik analisa kualitatif dan statistik. Dengan rumus TSR dan korelasi.Berdasarkan permasalahan di atas, penerapan model pembelajaran brain based learning di MIN 2 Palembang, dapat dilihat dari hasil analisa angket sebagai berikut: Penerapan model pembelajaran brain based learning di MIN 2 Palembang masuk dalam kategori sedang, hal ini dilihat dari jumlah responden (siswa) sebanyak 47 (78,33%) dari jumlah seluruh sampel sebanyak 60 (100%) orang siswa. Dan aktivitas balajar siswa di MIN 2 Palembang adalah dalam kategori sedang. Dalam hal ini siswa sebagai sampel penelitian jumlahnya sebanyak 60 (100%) orang siswa. Ternyata sebanyak 52 ( 86,67%) orang siswa memiliki aktivitas belajar pada kategori sedang.Adanya hubungan yang signifikan antara pelaksanaan model pembelajaran brain based learning terhadap aktivitas belajar siswa di bidang studi Ilmu Pengetahuan Alam, Hal ini dilihat dari hasil rxy yang besarnya 1,115 tersebut lebih besar dari harga r tabel baik pada taraf signifikan 5% yaitu 0,250 maupun pada taraf signifikan 1% yaitu 0,325. Oleh karena itu taraf signifikasi 5% (0,250) < 1,115> (0,325) pada tarag signifikasi 1%.
An Overview of the Quality of Life of Post Severe Brain Injury Patients within 2018-2020 Period of Time in Dr. Soetomo General Academic Hospital based on Short Form-36
Authors: Turchan Agus , Armando Alivery Raihanada , Andriana Meisy , Kusumawardani Martha Kurnia 
Published: August 2022

Highlight:

Until today, Traumatic Brain Injury is still a major cause of death, disability, and a serious health issue
Traumatic Brain Injury patients have a good quality of life if they get adequate therapy and on time interventions

ABSTRACT
Introduction: Approximately 90 million traumatic brain injury (TBI) cases worldwide exist yearly. TBI pathophysiology varies, which may cause diverse complications. These complications may decrease the patients’ quality of life. Objective: Describing the quality of life of traumatic brain-injured patients after being treated at Dr. Soetomo General Academic Hospital Period 2018-2020. Methods: This research is a descriptive cross-sectional study using SF-36 questionnaire data from patients with post-severe brain injury at Dr. Soetomo General Academic Hospital in 2018-2020. Results: The value of the physical component (59.9) and mental component (68.6) in patients with severe brain injury at Dr. Soetomo General Academic Hospital showed a good quality of life, with values ​​in the SF-36 domains, namely physical function (58.2), physical limitations (46.7), body pain (73.6), general health (61.3), vitality (65.3), social functioning (72.5), emotional limitations (60), and mental health (76.5) is above the threshold value (50) except for physical limitations (46.7).Conclusion: Patients with severe brain injury had a good quality of life after receiving treatment in Dr. Soetomo General Academic Hospital.
Partial Transvenous Coil Embolization with Significant Clinical Improvement in Patient with Indirect Carotid Cavernous Fistula
Authors: Yahya Muh. Wildan , Sani Achmad Firdaus , Kurniawan Dedy , Ardhi Mohammad Saiful 
Published: August 2022

Highlight:

CCF is a rare vascular malformation with challenging management.
Partial transvenous embolization is quite effective as an alternative therapy for indirect CCF type D.

ABSTRACT
Introduction: An indirect carotid-cavernous fistula (CCF) is an abnormal connection between the internal or external carotid artery and the cavernous sinus. The optic, trochlear, abducens, and trigeminal nerves are located in the cavernous sinus. Head Computed Tomography (CT) scan, Magnetic Resonance Imaging (MRI), and Cerebral Angiography are some imaging modalities used to establish and diagnose carotid-cavernous fistula. Endovascular intervention can be performed with trans-arterial or trans-venous access. In some cases, complete embolization by endovascular treatment is not possible because of difficult angioarchitecture. Case: A 61-year-old female reported having pain in her left eye (numerical rating scale was 6). The left eye was bulging, reddish, ptosis, and unable to move. The patient felt double vision when opening both eyes, complained of intermittent stabbing headaches on the left side, and heard a bruit from the left side of the head. The cerebral angiography showed bilateral indirect CCF Barrow type D. The procedure involved partial transvenous embolization with coiling. The angiographic evaluation showed partial occlusion, and residual flow from the fistula was still visible on angiography. There was a significant clinical improvement several days after the procedure and a five-month follow-up. Conclusion: This case report showed that partial targeted transvenous embolization is quite effective in indirect CCF when complete embolization is impossible.
Characteristics of Patients with Low Back Pain among Healthcare Professionals at John Piet Wanane General Hospital: A Cross-Sectional Study
Authors: Luhur Lu Jordy , Ruma Agustinus , Sugianto Paulus 
Published: August 2022

Highlight:

Healthcare professionals have a higher risk of suffering LBP than other industrial workers.
Adult women who have a high body mass index are likely to experience LBP.
Healthcare professional should maintain a healthy lifestyle to increase productivity and decrase mortality

ABSTRACT
Introduction: Low back pain (LBP) is musculoskeletal pain, tension, or stiffness that occurs below the costal margin and above the inferior gluteal folds, with or without sciatica. It has been found that healthcare professionals are more likely to experience LBP than other industrial workers. Many factors contribute to higher rates of LBP, including occupation, age, obesity, family history, lack of exercise, and psychosocial condition. Objective: To determine LBP’s prevalence and risk factors among healthcare professionals at John Piet Wanane General Hospital. Methods: This is a cross-sectional study that included 158 healthcare professionals. The data was collected using questionnaires and analyzed using univariate and multivariate logistic regression. Results: The overall prevalence of LBP in this study was 62.7%. Descriptive statistics showed that LBP was most common in the female group (71.7%), age group 35-50 years (52.5%), overweight group (61.6%), married group (80.8%), never or rarely exercise group (84.8%), non-smoking group (85.9%), non-drinkers group (84.8%), and moderate perceived stress group (63.6%). Multivariate logistic regression analysis showed that BMI was significantly associated with LBP. Compared with underweight participants, overweight participants were four times more likely to experience LBP (OR = 4.344, 95% CI: 1.297-14.552). Conclusion: This study demonstrates a high prevalence of LBP among healthcare professionals. High BMI, especially being overweight, increases the risk of developing LBP. Overweight and obesity among healthcare professionals may affect their credibility in providing patients with healthy nutrition and exercise advice. Healthcare professionals should maintain a healthy lifestyle to increase productivity and decrease mortality.
INFORMATION-ANALYTICAL SUPPORT OF DECISION MAKING IN THE PROJECTS DEVELOPMENT OF HARVESTING TECHNOLOGICAL SYSTEMS
Authors: Lub Pavlo , Berezovetskyi Sergiy , Padyuka Roman , Chubyk Roman 
Published: August 2022

The prerequisites for the creation and use of information-analytical systems for support decision-making in crop harvesting projects are revealed. The peculiarities of the projects environment impact on the implementation of winter rape harvesting projects are presented. Emphasis is placed on the importance of timely of works execution in crop harvesting projects, as well as solving tasks on coordination of content (technical equipment of technological processes of stem spraying and combine seed harvesting) and time of work in projects. The importance of the biological processes impact of winter rapeseed ripening and agrometeorological conditions on the time constraints of the technical equipment operation of projects is indicated. It is noted that this impact determines the variability of the timing of the start of work, as well as their duration and affects the functional performance of winter rapeseed harvesting projects. The necessity of taking into account of these features in the statistical simulation model of the technological system projects of rapeseed harvesting is proved. The development and results of the use of information and analytical system to support project management processes are presented. The method of taking into account the impact of the project environment (subject and agrometeorological conditions) on the timing and timeliness of work in harvesting projects is shown. The expediency of simulation models and methods creating of reflecting the probabilistic conditions of the technical equipment of agricultural crops harvesting projects are described. Computer experiments with a simulation model were performed with the initial data on technical equipment (high-clearance sprayer Mekosan Tecnoma Laser4240-30 and CLAAS Mega 360 combine), cultivar and limits of its production area. The peculiarities of the influence of the main components of crop harvesting projects on the indicators of their efficiency are revealed. The simulation was performed for the set limits of the production area of winter rape – 10-500 ha with a stepwise increase of 10 ha. Correlation dependences of functional indicators efficiency of technological systems on volumes of projects works taking into account influence of the project environment are established.