bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creation of a Novel Biomedical Engineering Research Course for Incarcerated Students
Authors: Speer Julie E. , Clapacs Zain 
Published: June 2022

AbstractOptions for incarcerated individuals to participate in higher education in prison programs (HEPPs) have expanded in recent years to include courses in science, technology, engineering, and mathematics, however these students remain an underserved population in the United States. Thus, there are opportunities to expand the available offerings, increase the diversity of coursework available by introducing subjects such as biomedical engineering (BME), and include cocurricular and extracurricular activities widely considered critical components of undergraduate training including research experiences. As such, a year-long program was developed to introduce students pursuing a bachelor’s degree in an HEPP through an R1 institution to research principles in BME. This course introduced students to disciplines within BME, offered opportunities to gain research experience as knowledge-creators, and supported engagement with a scientific learning community. Using a student-centered approach, the course was designed to incorporate activities for reflection, goal setting, and dialogue among participants and sought to leverage students’ funds of knowledge and areas of personal scientific interest. This course represents a transferable model for offering BME courses and research-centered opportunities to students enrolled in other HEPPs and an opportunity to promote equity and access in higher education.
Effects of pipe turns on vertical helically coiled tube heat exchangers for water heating in a household refrigerator
Authors: Missaoui Sami , Driss Zied , Slama Romdhane Ben , Chaouachi Bechir 
Published: June 2022

AbstractA new coupled numerical model of the overall vapor-compression cycle and water heater was developed in order to analyze the influence of condenser coil designs on the heat transfer process of a helical coil heat exchanger immersed in a storage tank. The model was developed using the CFD code ANSYS Fluent. In the numerical simulation, the helical condenser coil was treated as an internal heat source and the initial heat flux was obtained from experimental results and delivered to each coil element in the CFD model as boundary condition.The coupled model was validated with experimental results and showed that the numerical results of the proposed model are in good agreement with the experimental data with the deviation of ± 1.6%. Then, the impact of the main representative geometrical parameter on the overall heat transfer coefficient and water temperature distribution was investigated. The results indicated that the temperature distribution and overall heat transfer coefficient increase with the increase of the pipe turns of a helically coiled tube heat exchanger.
Mental Health Services Utilization by the Population That Suffered Water Supply Interruption Following Mariana Dam Failure (Brazil)
Authors: Dell’Aringa Marcelo F. , Correa-Oliveira Gabriel E. , Della Corte Francesco , Ragazzoni Luca , Miranda Elaine S. , Hubloue Ives , Murray Virginia , Barone-Adesi Francesco 
Published: June 2022

Abstract

Objective:
Disasters may have major impacts to mental health and to the utilization of mental health services (MHS). Moreover, these effects may be worsened by the preclusion of access to basic services following the event. The aim of this study is to evaluate the utilization of public MHS by the population that suffered water supply interruption following the Mariana Dam Failure in Brazil, 2015.

Methods:
We conducted an Interrupted Time Series analyzing secondary health data from the municipalities that faced water supply interruption, comparing it to data from the other municipalities of Minas Gerais state.

Results:
We found a higher immediate (RR: 1.78; 95% CI: 1.25–2.53) and gradual (RR: 1.05; 95% CI: 1.03–1.06) change in the rate of mental health visits (MHV) in the affected population following the event, whereas there was an immediate fall (RR: 0.41; 95% CI: 0.29–0.59) followed by a higher gradual increase (RR: 1.04; 95% CI: 1.02–1.06) in the rate of hospital admissions (HA) in the affected population.

Conclusion:
The results suggest that there was an increase in the utilization of public MHS by the population that suffered water supply interruption following the disaster.
How organizational politics and subjective social status moderate job insecurity–silence relationships
Authors: Son SuJin , Yang Tae Seok , Park Junsu 
Published: June 2022

AbstractDrawing upon the conservation of resources theory and self-determination theory, this study examines the subjective social status (SSS) of employees and how it moderates the two-way interaction effect of job insecurity and perceived organizational politics on the types of silence (i.e., acquiescent, and defensive silence [DS]). Using data of about 350 employees in South Korea, it was found that the relationship between job insecurity and employees' acquiescent silence (AS) was stronger for individuals who perceived their organizations as highly political. The results also indicated a three-way interaction between job insecurity, perceived organizational politics, and employees' SSS on employees' AS, such that in a highly political work environment, the relationship between job insecurity and employees' AS was stronger especially for employees with low social status. However, the same pattern did not exist between job insecurity and DS.
Induced aseismic slip and the onset of seismicity in displaced faults
Authors: Jansen Jan-Dirk , Meulenbroek Bernard 
Published: June 2022

Abstract
We address aseismic fault slip and the onset of seismicity resulting from depletion-induced or injection-induced stresses in reservoirs with pre-existing vertical or inclined faults. Building on classic results, we discuss semi-analytical modelling techniques for fault slip including dislocation theory, Cauchy-type singular integral equations and the use of Chebyshev polynomials for their solution and an eigenvalue-based stability analysis. We consider slip patch development during depletion for faults with zero, constant static and slip-weakening friction, and our results confirm earlier findings based on numerical simulation, in particular the aseismic growth of two slip patches that may subsequently merge and/or become unstable resulting in nucleation of seismic slip. New findings include improved approximate expressions for the induced seismic moment per unit strike length and a description of the effect of coupling between the slip patches which affects both forward simulation and eigenvalue computation for high values of the ratio of fault throw to reservoir height. Our implementation based on analytical inversion and semi-analytical integration with Chebyshev polynomials is more efficient and more robust than our numerical integration approach. It is not yet well suited for Monte Carlo simulation, which typically requires sub-second simulation times, but with some further development that option seems to be within reach. Moreover, our results offer a possibility for embedded fault modelling in large-scale numerical simulation tools.
Cereal and oil seed crops response to organic nitrogen when grown in rotation with annual aerial-seeded pasture legumes
Authors: Loi Angelo , Thomas Dean T. , Yates Ronald J. , Harrison Robert J. , D'Antuono Mario , Re Giovanni A. , Norman Hayley C. , Howieson John G. 
Published: June 2022

AbstractNitrogen fixation from pasture legumes is a fundamental process that contributes to the profitability and sustainability of dryland agricultural systems. The aim of this research was to determine whether well-managed pastures, based on aerial-seeding pasture legumes, could partially or wholly meet the nitrogen (N) requirements of subsequent grain crops in an annual rotation. Fifteen experiments were conducted in Western Australia with wheat, barley or canola crops grown in a rotation that included the pasture legume species French serradella (Ornithopus sativus), biserrula (Biserrula pelecinus), bladder clover (Trifolium spumosum), annual medics (Medicago spp.) and the non-aerial seeded subterranean clover (Trifolium subterraneum). After the pasture phase, five rates of inorganic N fertilizer (Urea, applied at 0, 23, 46, 69 and 92 kg/ha) were applied to subsequent cereal and oil seed crops. The yields of wheat grown after serradella, biserrula and bladder clover, without the use of applied N fertilizer, were consistent with the target yields for growing conditions of the trials (2.3 to 5.4 t/ha). Crop yields after phases of these pasture legume species were similar or higher than those following subterranean clover or annual medics. The results of this study suggest a single season of a legume-dominant pasture may provide sufficient organic N in the soil to grow at least one crop, without the need for inorganic N fertilizer application. This has implications for reducing inorganic N requirements and the carbon footprint of cropping in dryland agricultural systems.
Assessing national-level provision of conservation capacity building: lessons learnt from a case study of Kenya
Authors: O'Connell Mark , Donnison Amy , Lynch Kenny , Bennett Rachel 
Published: June 2022

AbstractAs global environmental pressures grow, the need for delivering relevant and sustainable capacity building in conservation has never been greater. Individuals, organizations and communities need the skills, knowledge and information that allow them to address environmental issues at a variety of spatial scales and in diverse contexts. Capacity is currently built through a range of activities, including tertiary education, training courses, online learning, mentoring and continuing professional development. However, a significant proportion of the current capacity-building provision is non-strategic, project-based and reactive. The conservation sector still lacks a coordinated approach to capacity building linked to broader conservation goals. Without an assessment of current capacity-building provision and future capacity needs, the delivery of capacity building in conservation will remain fundamentally ad hoc. The need for strategic conservation capacity building in sub-Saharan Africa has been identified and here we report on the first collation of online material to assess current conservation capacity provision in Kenya (the country with the greatest online capacity-building presence). We reviewed a total of 177 capacity-building initiatives delivered during 2014–2019 and recorded 55 separate metrics for each initiative. We present: (1) a broad overview of the data collation methods developed, (2) examples of data that will support strategic capacity-building strategies, and (3) the lessons learnt from this assessment.
A new hope for conserving the disjunct population of the Sierra Madre SparrowXenospiza baileyi: population size and new breeding localities in the Sierra Madre Occidental, Mexico
Authors: Aguirre-Calderón Carlos Enrique , Sánchez-Escalera Armando , Ruvalcaba-Ortega Irene , Aguirre-Calderón Cristóbal Gerardo , Vargas-Larreta Benedicto , Hernández Francisco J. , Canales-del-Castillo Ricardo , Gonzalez Rojas Jose Ignacio 
Published: June 2022

SummaryThe Sierra Madre SparrowXenospiza baileyiis an endangered Mexican endemic and a bunchgrassland specialist with a disjunct range: a relatively larger population in the south-eastern Trans-Mexican Volcanic Belt, and a smaller and poorly studied population in the Sierra Madre Occidental. In the latter, known distribution and abundance consists of four localities with a maximum of 28 individuals recorded in one of them. We surveyed the Sierra Madre Sparrow in 30 sites with suitable habitat, meadows or “bajíos” with bunchgrasses, in the municipalities of Durango, Pueblo Nuevo, San Dimas, and Canatlán in the Sierra Madre Occidental of Durango. We detected a total of 193 individuals in nine (30%) of the sites (392 ha), conducting intensive searches throughout them. Bunchgrasses in confirmed meadows were composed mainly ofMuhlenbergia macroura,M. rigida,M. speciosa,M. rigens, andPiptochaetium fimbriatum.Total bunchgrass area within a meadow was a significant positive predictor of the Sierra Madre Sparrow presence, while total meadow area was not a significant predictor of its abundance. Seven of the confirmed localities were previously unknown, and two of them harboured 55% of the observed individuals: Ex Hacienda Coyotes (Pueblo Nuevo) and La Lobera (San Dimas). The estimated population size is at least four times higher than any previous record (28) or suggested (40–50) for the Sierra Madre Occidental and raises an opportunity and a challenge for conserving this genetically distinct population of the Sierra Madre Sparrow in the region.
Case series: propranolol liquid in the treatment of tachyarrhythmias in neonates and infants: potential for errors
Authors: Renwick Catherine E. , Makhecha Sukeshi , Till Jan 
Published: June 2022

AbstractOral propranolol therapy is commonly used for the prevention of tachyarrhythmias in infancy and childhood. Propranolol is commercially produced in four concentrations allowing varying volumes to be administered. However, quite often an alternative strength of propranolol liquid is issued without clear change in instructions or warning. This may lead to parents inadvertently administering the wrong dose.
An unobserved components model of total factor productivity and the relative price of investment
Authors: Chan Joshua C.C. , Wemy Edouard 
Published: June 2022

AbstractThis paper applies the common stochastic trends representation approach to the time series of total factor productivity (TFP) and the relative price of investment (RPI) to investigate the modeling of neutral technology (NT) and investment-specific technology (IST) and its econometric ramifications on the analysis of general equilibrium model. The permanent and transitory movements in both series are estimated efficiently via Markov chain Monte Carlo methods using band matrix algorithms. The results indicate that TFP and the RPI are, each, well represented by a differenced first-order autoregressive process. In addition, their time series share a common trend component that we interpret as reflecting changes in general purpose technology. These results are consistent with studies that suggest that (1) the traditional view of assuming that NT and IST follow independent processes is not supported by the features of the time series and (2) improper specification of secular trends may distort estimation and inference. Notably, the findings provide some guidance to minimize the effect of idiosyncratic and common trend misspecifications on the analysis of impulse dynamics and propagation mechanisms in macroeconomic models.
Trends in Dizygotic and Monozygotic Spontaneous Twin Births During the Period 2007–2017 in Lombardy, Northern Italy: A Population-Based Study
Authors: Esposito Giovanna , Dalmartello Michela , Franchi Matteo , Mauri Paola Agnese , Cipriani Sonia , Corrao Giovanni , Parazzini Fabio 
Published: June 2022

AbstractIn this study, we analyzed the estimated frequency of monozygotic (MZ) and dizygotic (DZ) spontaneous twins in Lombardy during the period 2007−2017. This is a population-based study using the regional healthcare utilization databases of the Lombardy Region. The total number of spontaneous twin deliveries, in separate strata of like and unlike sex, was obtained. Moreover, estimates of DZ and MZ twin births were calculated using Weinberg’s method. The standardized rates (SRs), adjusted for maternal age, of DZ and MZ twin births were computed according to calendar period. The twinning rates were calculated among strata of parity and maternal age. Finally, DZ:MZ ratio was calculated. Among the 734,278 spontaneous deliveries, 9176 (12.5 out of 1000 births) couples of twins were identified. In the three periods considered (i.e. 2007−2010, 2011−2014 and 2015−2017), no trend in the SRs of MZ twins was observed, respectively 0.41 (95% CI [0.40, 0.43]), 0.43 (95% CI [0.42, 0.45]) and 0.43 (95% CI[0.42, 0.45]). Differently, a slightly decreasing trend was observed in DZ twins SRs, respectively 0.87 (95% CI [0.84, 0.89]), 0.81 (95% CI [0.79, 0.83]), and 0.78 (95% CI [0.76, 0.80]). As concerns parity and maternal age, the rate of DZ twin births was consistently higher in nulliparae women aged 35 years or more. In our cohort, despite the increase of maternal age, a decline of spontaneous twin births emerged, especially due to the downward trend of DZ twins.
Insect Herbivory Caused Plant Stress Emissions Increases the Negative Radiative Forcing of Aerosols
Authors: Holopainen E. , Kokkola H. , Faiola C. , Laakso A. , Kühn T. 
Published: June 2022

AbstractPlant stress in a changing climate is predicted to increase plant volatile organic compound (VOC) emissions and thus can affect the formed secondary organic aerosol (SOA) concentrations, which in turn affect the radiative properties of clouds and aerosol. However, global aerosol‐climate models do not usually consider plant stress induced VOCs in their emission schemes. In this study, we modified the monoterpene emission factors in biogenic emission model to simulate biotic stress caused by insect herbivory on needleleaf evergreen boreal and broadleaf deciduous boreal trees and studied the consequent effects on SOA formation, aerosol‐cloud interactions as well as direct radiative effects of formed SOA. Simulations were done altering the fraction of stressed and healthy trees in the latest version of ECHAM‐HAMMOZ (ECHAM6.3‐HAM2.3‐MOZ1.0) global aerosol‐climate model. Our simulations showed that increasing the extent of stress to the aforementioned tree types, substantially increased the SOA burden especially over the areas where these trees are located. This indicates that increased VOC emissions due to increasing stress enhance the SOA formation via oxidation of VOCs to low VOCs. In addition, cloud droplet number concentration at the cloud top increased with increasing extent of biotic stress. This indicates that as SOA formation increases, it further enhances the number of particles acting as cloud condensation nuclei. The increase in SOA formation also decreased both all‐sky and clear‐sky radiative forcing. This was due to a shift in particle size distributions that enhanced aerosol reflecting and scattering of incoming solar radiation.
Sex differences in plasma p-tau181 associations with Alzheimer’s disease biomarkers, cognitive decline, and clinical progression
Authors: Tsiknia Amaryllis A. , Edland Steven D. , Sundermann Erin E. , Reas Emilie T. , Brewer James B. , Galasko Douglas , Banks Sarah J. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: June 2022

AbstractStudies have shown that women on the Alzheimer’s disease (AD) continuum have more pathological tau in the brain and cerebrospinal fluid (CSF), than men. Some studies have found that higher levels of tau biomarkers are more strongly associated with clinical AD, cognitive decline and neurodegeneration in women than in men. Despite major developments in the use of plasma tau phosphorylated at threonine 181 (p-tau181) as an AD biomarker, it is unknown whether these sex differences apply to plasma p-tau181. In 1060 Alzheimer’s Disease Neuroimaging Initiative (ADNI) participants (47% women, 73.8 ± 7.6 years old), we examined sex differences in plasma p-tau181 levels and their association with other biomarkers, cognitive decline and incident AD. Linear regressions tested for an effect of sex on plasma p-tau181 levels and for plasma p-tau181 × sex interactions on CSF p-tau181, as well as entorhinal cortex tau, cortical amyloid-β (Aβ) deposition, and brain glucose metabolism, quantified using PET imaging. Linear mixed effects models tested for a sex × baseline plasma p-tau181 interaction on change in cognition over time. Finally, Cox models tested for a sex × plasma p-tau181 interaction on the risk of AD dementia in participants who were free of dementia at baseline. Despite similar plasma p-tau181 levels between sexes, women had lower brain glucose metabolism, greater brain Aβ and entorhinal cortex tau deposition, higher CSF p-tau181 and faster cognitive decline in relation to higher baseline plasma p-tau181 levels compared with men. Among Aβ positive, dementia-free participants, women had higher rates of incident AD dementia associated with increasing baseline plasma p-tau181 levels, relative to men. Our results suggest that sex may impact the clinical interpretation of plasma p-tau181 concentrations. If replicated, these findings could have important implications for the use of plasma p-tau181 as an accessible AD biomarker and screening tool for preventive and therapeutic clinical trials.
Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance
Authors: Tarantino Dalia , Walker Callum , Weekes Daniel , Pemberton Helen , Davidson Kathryn , Torga Gonzalo , Frankum Jessica , Mendes-Pereira Ana M. , Prince Cynthia , Ferro Riccardo , Brough Rachel , Pettitt Stephen J. , Lord Christopher J. , Grigoriadis Anita , NJ Tutt Andrew 
Published: June 2022

AbstractHORMAD1 expression is usually restricted to germline cells, but it becomes mis-expressed in epithelial cells in ~60% of triple-negative breast cancers (TNBCs), where it is associated with elevated genomic instability (1). HORMAD1 expression in TNBC is bimodal with HORMAD1-positive TNBC representing a biologically distinct disease group. Identification of HORMAD1-driven genetic dependencies may uncover novel therapies for this disease group. To study HORMAD1-driven genetic dependencies, we generated a SUM159 cell line model with doxycycline-inducible HORMAD1 that replicated genomic instability phenotypes seen in HORMAD1-positive TNBC (1). Using small interfering RNA screens, we identified candidate genes whose depletion selectively inhibited the cellular growth of HORMAD1-expressing cells. We validated five genes (ATR, BRIP1, POLH, TDP1 and XRCC1), depletion of which led to reduced cellular growth or clonogenic survival in cells expressing HORMAD1. In addition to the translesion synthesis (TLS) polymerase POLH, we identified a HORMAD1-driven dependency upon additional TLS polymerases, namely POLK, REV1, REV3L and REV7. Our data confirms that out-of-context somatic expression of HORMAD1 can lead to genomic instability and reveals that HORMAD1 expression induces dependencies upon replication stress tolerance pathways, such as translesion synthesis. Our data also suggest that HORMAD1 expression could be a patient selection biomarker for agents targeting replication stress.