bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensing miRNAs for Disease Diagnostics
Authors: Deng Linyi , Guo Pei , Han Da , Tan Weihong 
Published: October 2022

AbstractmiRNAs are short nucleic acid sequences that regulate gene expression and are important biomarkers for disease diagnostics. In this Review, we overview the biogenesis and functions of miRNAs. The recent progress of biomarker development based on miRNAs is further discussed. In the end, we summarize the progress on miRNA detection methods towards clinical diagnostics. Although proper tools and standardized methodology in detection are still the bottlenecks for miRNA‐based diagnosis, the challenges are likely to be overcome with the development of new bioanalytical techniques. More importantly, upstream studies to elucidate mechanisms of miRNAs in target recognition and correlation with diseases will further advance the clinical use of miRNAs as biomarkers.
Continuous film casting of polycarbonate/single‐walled carbon nanotubes composites with ultrasound‐assisted twin‐screw extruder: Effect of screw configuration
Authors: Gao Xiang , Isayev Avraam I. , Zhang Xiaoping 
Published: October 2022

AbstractPolymer films are widely used in various industries, and incorporation of nanofillers into polymer films can give much more versatility in their applications. Polymer/carbon nanotubes (CNTs) composite films with good electrical conductivity can easily find applications in anti‐static or electrostatic discharge (ESD) protection. In the present study, efforts were devoted to investigate novel ultrasound‐assisted twin‐screw extrusion technology on improving the dispersion and distribution of single‐walled carbon nanotubes (SWNTs) in polycarbonate (PC) composites films via extrusion process. As a key processing parameter, effect of screw configuration on the performance of the composite films were systematically studied. Electrical, rheological, morphological and mechanical properties were characterized to illustrate the processing‐structure–property relationship during continuous film casting of PC/SWNTs composites with ultrasound‐assisted twin‐screw extruder. Results indicated that the screw configuration containing more kneading blocks led to better SWNTs dispersion and distribution, while the effect of ultrasound was more prominent in screw design with less kneading blocks.
Significantly improving the Cu2+ removal performance of conducting polymer‐based adsorbent from aqueous solution through cross‐linking modification
Authors: Mamat Kamila , Muslim Arzugul , Lan Haidie , Malik Dilnur , Musajan Aynur 
Published: October 2022

AbstractThrough cross‐linking modification of poly(o‐phenylenediamine) (PoPD) to increase the adsorption active sites, the Cu2+ adsorption capacity of PoPD was improved significantly. According to FT‐IR, XRD, SEM and BET results, both PoPD and the cross‐linked PoPD had porous or surface‐adhesive porous morphology with a typical mesoporous character, the specific surface area of the latter was increased obviously from the former. Both of them showed excellent Cu2+ adsorption capabilities with the maximum adsorption qexpmax of 76.51 and 85.49 mg·g−1, and the corresponding removal ratios of 60.21% and 68.39%, respectively. The adsorption capacity was increased to its 1.54 times with pentaerythritol tris[3‐(1‐aziridinyl)propionate] (cross‐linking agent‐III) as cross‐linking agent at pH = 5 and 25°C. Because temperature could affect the adsorption behavior of materials and the adsorption process is endothermic with ΔG < 0, the process should be accompanied by spontaneous chemical changes. The XRD, SEM–EDX mapping and XPS results showed that Cu2+ was successfully removed from the aqueous solution. Additionally, the adsorption was mainly based on the cation‐π interaction and the formation of Cu‐N bonds.
A feeling for the data: How government and nonprofit stakeholders negotiate value conflicts in data science approaches to ending homelessness
Authors: Slota Stephen C. , Fleischmann Kenneth R. , Lee Min Kyung , Greenberg Sherri R. , Nigam Ishan , Zimmerman Tara , Rodriguez Sarah , Snow James 
Published: October 2022

AbstractGovernmental and organizational policy increasingly claims to be data‐driven, data‐informed, or knowledge‐driven. We explore the data practices of local governments and nonprofits a seeking to end homelessness in the City of Austin. Drawing on 31 interviews with stakeholders, alongside the reflections and experiences of our interdisciplinary, cross‐sector collaborative team, we consider the role of data in guiding and informing interventions and policy regarding homelessness. Ending homelessness is a particularly challenging scenario for intervention, with increasing politicization, changing circumstances, and needing rapid intervention to reduce harm. In exploring some implications of data science “in the wild” as it is deployed, understood, and supported within the Travis County Continuum of Care (CoC), we analyze how data‐intensive work connects and engages across disciplinary boundaries. Furthermore, we consider how data science and the iField can collaborate in addressing complex, social problems as advisors and partners with invested organizations.
Observer‐based finite‐time H∞ control of Itô‐type stochastic nonlinear systems
Authors: Wang Guanzheng , Zhao Feng , Chen Xiangyong , Qiu Jianlong 
Published: October 2022

AbstractThis paper investigates the finite‐time
control of Itô‐type stochastic nonlinear systems. Considering the transient performance and anti‐interference ability within a given limited time interval, the control strategy of stochastic nonlinear systems is researched. A new sufficient condition for mean‐square finite‐time boundedness for stochastic nonlinear system is developed. Due to the state components are not available, a state observer is designed. Based on the estimated state, an
controller is proposed and Linear Matrix Inequality (LMI) conditions are given, which not only guarantee the mean‐square finite‐time boundedness but also satisfy the corresponding
performance. Finally, two examples are given to demonstrate the effectiveness of the results.
Inhibition of canalicular and sinusoidal taurocholate efflux by cholestatic drugs in human hepatoma HepaRG cells
Authors: Le Vée Marc , Moreau Amélie , Jouan Elodie , Denizot Claire , Parmentier Yannick , Fardel Olivier 
Published: October 2022

AbstractHepaRG cells are highly‐differentiated human hepatoma cells, which are increasingly recognized as a convenient cellular model for in vitro evaluation of hepatic metabolism, transport, and/or toxicity of drugs. The present study was designed to evaluate whether HepaRG cells can also be useful for studying drug‐mediated inhibition of canalicular and/or sinusoidal hepatic efflux of bile acids, which constitutes a major mechanism of drug‐induced liver toxicity. For this purpose, HepaRG cells, initially loaded with the bile acid taurocholate (TC), were reincubated in TC‐free transport assay medium, in the presence or absence of calcium or drugs, before analysis of TC retention. This method allowed us to objectivize and quantitatively measure biliary and sinusoidal efflux of TC from HepaRG cells, through distinguishing cellular and canalicular compartments. In particular, time‐course analysis of the TC‐free reincubation period of HepaRG cells, that is, the efflux period, indicated that a 20 min‐efflux period allowed reaching biliary and sinusoidal excretion indexes for TC around 80% and 60%, respectively. Addition of the prototypical cholestatic drugs bosentan, cyclosporin A, glibenclamide, or troglitazone during the TC‐free efflux phase period was demonstrated to markedly inhibit canalicular and sinusoidal secretion of TC, whereas, by contrast, incubation with the noncholestatic compounds salicylic acid or flumazenil was without effect. Such data therefore support the use of human HepaRG cells for in vitro predicting drug‐induced liver toxicity (DILI) due to the inhibition of hepatic bile acid secretion, using a biphasic TC loading/efflux assay.
Benzothioxanthene Dicarboximide as a Tuneable Electrogenerated Chemiluminescence Dye
Authors: Dauphin Alice L. , Andrés Castán José María , Yu Jing , Blanchard Philippe , Sojic Neso , Ahn Hyun S. , Walker Bright , Cabanetos Clément , Bouffier Laurent 
Published: October 2022

AbstractOverlooked for years, the promising benzothioxanthene dicarboximide (BTXI) structure is nonetheless known to be an excellent fluorophore. As a further step towards the exploration of this rylene structure, the generation of electrochemiluminescence (ECL) in acetonitrile solutions is investigated herein as well as its direct comparison with a diphenylamine (DPA) derivative. Electrochemical characterization shows that the bare BTXI can be reversibly reduced or oxidized, characteristics which suggest the possibility that the electrogenerated reactive species can be exploited in the context of ECL. As a result, the BTXI moiety was found to be ECL‐active in both annihilation and co‐reactant mechanisms. Tri‐n‐propylamine (TPA) and benzoyl peroxide (BPO) were selected as sacrificial co‐reactants for promoting ECL. An ECL efficiency of 13 % (BTXI) and 6 % (BTXI‐DPA) compared to that of Ru(bpy)32+ was found when using TPA in oxidative ECL. Moreover, the ECL efficiency increased to 75 % and 55 % of Ru(bpy)32+ with BPO (i. e. reductive‐oxidation ECL) for BTXI and BTXI‐DPA, respectively. These results can be understood by calculating the free enthalpy of the redox reactions associated with each ECL pathway. Although the BTXI‐DPA red emitter exhibits more suitable thermodynamic properties, the BTXI green emitter is nonetheless more effective in combination with a co‐reactant due to a much larger photoluminescence quantum yield. The ECL spectra of the two molecules are compared to their photoluminescence spectra, revealing the involvement of the same excited states in the two different photoemission processes. In turn, the chemical engineering of BTXI is shown to be an effective platform for achieving tuneable ECL generation.
Fuzzy expert system for troubleshooting of the deodorizer unit in a palm oil refining plant
Authors: Salleh Intan Suhairi , Ali Nur Syuhada , Hourfar Farzad , Yusof Khairiyah Mohd , Sulaiman Nurul Sulaiha , Jamaluddin Hishamuddin , Zahedi Gholamreza , Almansoori Ali , Elkamel Ali 
Published: October 2022

AbstractIn this paper, a troubleshooting technique is developed to provide a sequence of necessary actions during deodorizer unit failure in a palm oil refinery. This paper introduces a fuzzy expert system that incorporates the knowledge of experienced plant workers in dealing with the complex problems of the palm oil deodorizer. The presented methodology uses both qualitative and quantitative data. Qualitative data are collected from several interview sessions with the technical staff in a palm oil refinery. Quantitative data are gathered from various sources, such as control and monitoring systems. The qualitative data are analyzed to discover the possible pattern of faults in the deodorizer failure. This tool can diagnose possible faults and provide a sequence of necessary actions when deodorizer failure occurs. The obtained results show the developed deodorizer troubleshooting tool is useful to guide plant workers/operators in diagnosing the possible faults and abnormalities during the troubleshooting process, as well as to provide field training for inexperienced staff.
Removal of glyphosate from aqueous solution by CuO coated MIL‐101(Fe)
Authors: Jia Dongmei , Guo Jia , Li Jing , Duan Yongzheng 
Published: October 2022

AbstractThe composite of CuO coated MIL‐101(Fe) (CuO@MIL‐101(Fe)) was successfully prepared using a one‐pot hydrothermal technology. X‐ray diffraction (XRD), Fourier transform infrared spectrum (FTIR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), Brunauer–Emmett–Teller (BET), and TG technologies were used to characterize its structural, morphological, and physicochemical properties. CuO@MIL‐101(Fe) exhibited a better pH adaptivity, a faster removal ratio of 95.8% for glyphosate within 10 min at pH 7, and a higher selectivity of adsorption capacity, even reaching 231.6 and 233.5 mg g−1 with coexisting Cl− (10 mmol L−1) and SO42− (10 mmol L−1). The enhanced adsorption performances of CuO@MIL‐101(Fe) may be caused by Cu forming a coordination interaction with glyphosate. A possible mechanism of glyphosate removal was discussed on the basis of the FTIR and X‐ray photoelectron spectroscopy (XPS) analysis. CuO@MIL‐101(Fe) composite would be more favourable to capture glyphosate from wastewater.
Subcutaneous birch pollen allergen immunotherapy with a depigmented polymerized extract shows only sustained and long‐term efficacy in a subgroup of monosensitized adults and adolescents with allergic rhinitis
Authors: Novak Natalija , Worm Margitta , Staubach Petra , Jutel Marek , Sager Angelika , Pfaar Oliver 
Published: October 2022

AbstractBackgroundAllergen immunotherapy (AIT) is an approved treatment for seasonal respiratory allergic diseases. A depigmented polymerized birch pollen extract for subcutaneous allergen immunotherapy (SCIT) has been demonstrated to be efficacious and safe in patients allergic to birch pollen and its homologous group.ObjectiveTo determine whether SCIT with a birch pollen formulation (5000 depigmented polymerized (DPP) units/mL) shows sustained and long‐term efficacy in adults and adolescents with birch‐pollen induced allergic rhinitis with or without intermittent asthma.MethodsA multicentre (n = 66), double‐blind, placebo‐controlled Phase III clinical trial was performed in the Czech Republic, Finland, Germany, Latvia, Lithuania, Poland and Russia. Participants were randomized 2:1 to active treatment (birch 5000 DPP/ml) or placebo for three years of SCIT and followed up for two treatment‐free years. The primary efficacy endpoint was the EAACI's combined symptom and medication score for rhinoconjunctivitis (CSMSEAACI).ResultsA total of 973 participants were screened and 649 were randomized (active treatment: n = 434; placebo: n = 215). The intention‐to‐treat analysis of the CSMSEAACI in the overall study population did not demonstrate statistically significant differences in years 1, 2 and 3. In a post‐hoc analysis, among the subgroup of patients monosensitized to birch pollen allergen only (n = 200), we observed a statistically significant difference (active treatment vs. placebo) in the CSMSEAACI in year 2, 3 and 5. The AIT's safety profile was good.ConclusionsSCIT with a depigmented polymerized birch pollen extract was safe. Sustained and long‐term efficacy in years 2, 3 and 5 in monosensitized patients, but not in polysensitized patients was demonstrated.(EudraCT 2012‐000414‐11)
Subclones of bone marrow CD34+ cells in acute myeloid leukemia at diagnosis confer responses of patients to induction chemotherapy
Authors: Jia Ruinan , Ji Min , Li Guosheng , Xia Yuan , Guo Shouhui , Li Peng , Sun Yanping , Lu Fei , Zhang Jingru , Zang Shaolei , Yan Shuxin , Ye Jingjing , Xue Fuzhong , Ma Daoxin , Sun Tao , Ji Chunyan 
Published: October 2022

AbstractBackgroundAcute myeloid leukemia (AML) is a hematopoietic malignancy with a prognosis that varies with genetic heterogeneity of hematopoietic stem/progenitor cells (HSPCs). Induction chemotherapy with cytarabine and anthracycline has been the standard care for newly diagnosed AML, but about 30% of patients have no response to this regimen. The resistance mechanisms require deeper understanding.MethodsIn our study, using single‐cell RNA sequencing, we analyzed the heterogeneity of bone marrow CD34+ cells from newly diagnosed patients with AML who were then divided into sensitive and resistant groups according to their responses to induction chemotherapy with cytarabine and anthracycline. We verified our findings by TCGA database, GEO datasets, and multiparameter flow cytometry.ResultsWe established a landscape for AML CD34+ cells and identified HSPC types based on the lineage signature genes. Interestingly, we found a cell population with CRIP1highLGALS1highS100Ashigh showing features of granulocyte‐monocyte progenitors was associated with poor prognosis of AML. And two cell populations marked by CD34+CD52+ or CD34+CD74+DAP12+ were related to good response to induction therapy, showing characteristics of hematopoietic stem cells.ConclusionOur study indicates the subclones of CD34+ cells confers for outcomes of AML and provides biomarkers to predict the response of patients with AML to induction chemotherapy.
Ectopic adrenocorticotropic hormone‐secreting carcinoid with solitary cryptococcosis in the lungs
Authors: Takagi Hironori , Matsumura Yuki , Fukuhara Mitsuro , Inomata Sho , Yamaguchi Hikaru , Watanabe Masayuki , Ozaki Yuki , Muto Satoshi , Okabe Naoyuki , Shio Yutaka , Saito Haruka , Tanabe Hayato , Shimabukuro Michio , Suzuki Hiroyuki 
Published: October 2022

AbstractBackgroundCarcinoid tumors can on rare occasions ectopically produce adrenocorticotropic hormone (ACTH), causing Cushing's syndrome, and patients could become immunocompromised. Care must therefore be taken regarding infectious complications. In particular, ACTH‐producing pulmonary carcinoid is not easy to diagnose by itself, and when combined with pulmonary nodules as infectious foci, each is very difficult to diagnose.CaseThe patient was a 71‐year‐old woman with refractory diabetes. She showed clinical symptoms of Cushing's syndrome during treatment for diabetes and ectopic ACTH production was suspected based on biochemical and imaging tests. Nodules were identified in the left lung apex and lingual segment. Examination of resected nodules revealed that the nodule in the apex was pulmonary cryptococcosis, while the nodule in the lingual segment represented typical carcinoid. After surgery, clinical symptoms, laboratory findings, and diabetes all improved.ConclusionWe present this very instructive case in terms of the difficulty of diagnosing ACTH‐producing tumors, the possibility of infection complicating the immunodeficiency caused by ACTH‐producing tumors, and the surgical strategy.
How do female CEOs affect corporate environmental policies?
Authors: Zhang Ying , Guo Yuting , Nurdazym Aiman 
Published: October 2022

AbstractHow do female Chief Executive Officers (CEOs) affect corporate environmental policies? This study develops a theoretical argument by incorporating the role of gender into the context of corporate environmental policies. Specifically, we differentiate corporate environmental policies into sustainable and unsustainable environmental policies. We also hypothesize a positive relationship between female CEOs and corporate sustainable environmental policies because women possess communal qualities and tend to be more stakeholder‐oriented compared with men. Moreover, we also propose a negative relationship between female CEOs and corporate unsustainable environmental policies because of women's risk aversion. We further predict that female CEOs with in‐group members will enhance the behavioral preferences of female leaders. Thus, we propose that the presence of in‐group members strengthens the relationship between female CEOs and corporate environmental policies. Using a longitudinal data set of Chinese listed firms from 2008 to 2018, we found strong empirical support for our predictions. Implications for the literature on gender and corporate environmental policies are also discussed.
Conserving diversity in Irish plant–pollinator networks
Authors: Russo Laura , Fitzpatrick Úna , Larkin Michelle , Mullen Sarah , Power Eileen , Stanley Dara , White Cian , O'Rourke Aoife , Stout Jane C. 
Published: October 2022

AbstractBeneficial insects provide valuable services upon which we rely, including pollination. Pollinator conservation is a global priority, and a significant concern in Ireland, where over half of extant bee species have declined significantly in recent decades. As flower‐visiting insects rely on flowering plants, one way to conserve and promote pollinator populations is to protect high‐quality habitat. We analyzed the structure of insect–flower interactions from multiple habitat categories in a large database of interactions from Ireland. Our primary goals were to compare spatial and temporal variation in Irish network structures, compare Irish networks to published networks from other countries, and provide evidence‐based recommendations for pollinator conservation in Ireland by identifying well‐visited plant species that may promote high pollinator diversity, abundance, and functional complementarity. Habitat types within Ireland differed substantially: seminatural grasslands had the highest pollinator species richness and largest number of unique pollinator species, while intensively managed habitats exhibited negative asymmetry (more plant than pollinator species). This negative asymmetry is notable because most plant–pollinator networks exhibit a positive asymmetry. Within intensively managed habitats, agricultural and urban habitats differed. Urban habitats had the highest number of non‐native plant species while agricultural habitats had the lowest pollinator species richness. We also found Irish networks varied across the growing season, where July had the highest plant and insect species richness. When comparing Irish networks to published networks from other countries, we found Irish networks had a higher ratio of plant species to pollinator species, and that this difference was most evident in agricultural habitats. This ratio means the typical network asymmetry (more pollinator than plant species) was flipped (more plant than pollinator species) in the Irish network. We conclude that conserving seminatural grasslands in Ireland will be an essential component of pollinator conservation and identify thirty‐five plant species important for restoring seminatural habitats.
Intra‐annual growing season climate variability drives the community intra‐annual stability of a temperate grassland by altering intra‐annual species asynchrony and richness in Inner Mongolia, China
Authors: Zhang Ze , Bao Tiejun , Hautier Yann , Yang Jie , Liu Zhongling , Qing Hua 
Published: October 2022

AbstractUnderstanding the factors that regulate the functioning of our ecosystems in response to environmental changes can help to maintain the stable provisioning of ecosystem services to mankind. This is especially relevant given the increased variability of environmental conditions due to human activities. In particular, maintaining a stable production and plant biomass during the growing season (intra‐annual stability) despite pervasive and directional changes in temperature and precipitation through time can help to secure food supply to wild animals, livestock, and humans. Here, we conducted a 29‐year field observational study in a temperate grassland to explore how the intra‐annual stability of primary productivity is influenced by biotic and abiotic variables through time. We found that intra‐annual precipitation variability in the growing season indirectly influenced the community intra‐annual biomass stability by its negative effect on intra‐annual species asynchrony. While the intra‐annual temperature variability in the growing season indirectly altered community intra‐annual biomass stability through affecting the intra‐annual species richness. At the same time, although the intra‐annual biomass stability of the dominant species and the dominant functional group were insensitive to climate variability, they also promoted the stable community biomass to a certain extent. Our results indicate that ongoing intra‐annual climate variability affects community intra‐annual biomass stability in the temperate grassland, which has important theoretical significance for us to take active measures to deal with climate change.