bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does early lifetime overweight modify the association between adult BMI and the risk of knee arthroplasty, as measures of severe knee osteoarthritis? A prospective Danish cohort study
Authors: Tryggedsson Jeppe Schmidt , Ersbøll Annette Kjær , Bliddal Henning , Heitmann Berit Lilienthal 
Published: September 2022

Abstract
Background: Only few studies have explored whether BMI across life is associated with knee OA. The aim of this study was to examine if the risk of knee arthroplasty related to adult BMI is modified by early lifetime overweight.Methods: A total of 22 083 female nurses were followed from 1st of May 1999 until 10th of August 2015, date of knee arthroplasty or censoring (emigration, end of study or death). At baseline participants completed a questionnaire on different lifestyle-related factors. Knee arthroplasty events were identified through linkage to the Danish National Patient Register. The association was examined using Poisson regression of incidence rate of knee arthroplasty.Results: A direct association was found between BMI and rate of knee arthroplasty. The largest difference in the incidence rate of knee arthroplasty per unit increase in BMI was seen among women with no early lifetime overweight (IRR: 1.15, 95% CI: 1.13; 1.17), while the smallest difference was seen among women with early lifetime overweight (IRR: 1.09, 95% CI: 1.06; 1.12).Conclusion: Early lifetime overweight seems to modify the association between BMI and knee arthroplasty, suggesting a lower incidence rate for obese women with early lifetime overweight than obese women without early lifetime overweight.
Identification of Different Dairy Products Using Raman Spectroscopy Combined with Fused Lasso Distributionally Robust Logistic Regression
Authors: Xu Xiang , Xiao Wentao , Cao Yiyun , Zhang Zhengyong 
Published: September 2022

Abstract

Raman spectroscopy has been more and more widely used in the quality detection of dairy products. Due to the characteristics of high dimension and small sample size, the rapid, intelligent and accurate identification method of Raman spectroscopy is becoming one of the hot issues for researchers. In order to improve the robustness and accuracy of logistic regression identification method, a new Raman spectroscopy identification method is proposed by combining distributionally robust optimization technique and fused lasso technique with logistic regression. Raman spectroscopy of two kinds of dairy products were collected respectively for anti-jamming identification testing to verify the effectiveness of the new method. Experimental results show that the proposed method is more robust and has higher recognition accuracy than the traditional logistic regression.
A semantic-driven tradespace framework to accelerate aircraft manufacturing system design
Authors: Zheng Xiaochen , Hu Xiaodu , Arista Rebeca , Lu Jinzhi , Sorvari Jyri , Lentes Joachim , Ubis Fernando , Dimitris  
Published: September 2022

Abstract
During the design phase of an aircraft manufacturing system, different industrial scenarios need to be evaluated according to key performance indicators to achieve the optimal system performance. It is a highly complex process involving multidisciplinary stakeholders, various digital tools and protocols. To address the digital discontinuity challenge during this process, this paper proposes a tradespace framework based on semantic technology and Model-Based Systems Engineering. It aims at functionality integration of requirement management, architecture definition, manufacturing system design, solution verification and visualization. An application ontology is developed to integrate assembly system domain knowledge, industrial requirements and system architecture model information. The proposed framework is implemented in a case study to support the fuselage orbital joint process design, which is part of the aircraft Final Assembly Line. A toolchain is presented to support the implementation, which consists of a set of enabling software corresponding to the functional modules of the framework. Different manufacturing system architectures are first designed by industrial system engineers supported by the application ontology stored in a graph database. They are then analyzed through Discrete Event Simulations and 3D simulations. The simulation results are presented through a web-based portal to show the key performance values of each architecture. This study serves as a part of the proof-of-concept of the recently proposed Cognitive Digital Twin concept.
Structural characterization of former mining works in the North west Formations of Lake Kivu (case of Bishasha, DR Congo)
Authors: GLOIRE SADIKI BARATA 
Published: September 2022

Abstract
The formations of western Lake Kivu are typical of Mesoproterozoic that is dominated essentially by metasedimentary rocks with a minor part of metavolcanic rocks cutting by massive granit. The sector of Bishasha is constituted by quartzite, shale that aren’t spoilt in which once we exploited wolframite ore. That mineralisation is often presented like stockwerks.The regional tectonics which affected Bishasha sector led to brittle microstructures which attest to the extensive phase experienced by this terrain, confirmed even in the study of stress by WINTENSOR. The preferential direction of cleavage NNE-SSW would justify the existence of regional folding and even coincides with the orientation of the main stress NNE-SSW which corresponds to the first phase of deformation that affected the kibarian chain
Gravitational folding of surface tension regions originates bio quantum path duality that quantizes Newtonian rigid inertia into parameter trigonometric inversion topological bio-inertia
Authors: Lai Yi Yu 
Published: September 2022

Abstract
Universal interaction reference systems in nature can’t avoid elastic inversion(memory). Newton established the parameter quantity-driving rigid reference system with zero inversion. Bio-systems fall to another extremity that can only utilize inversion energy without rigidness. We define inversion energy as parameter-against-gravity- internal-fluctuation for this system, write down modifications of Newtonian Three Laws as, first law: (𝑑/𝑑𝑥)cosx =−𝑠𝑖𝑛𝑥, (𝑑/𝑑𝑥)sinx = 𝑐𝑜𝑠𝑥; second law: 𝐹⃗=𝑚∙𝑎⃗ + |𝑚𝑔⃗∫𝑡𝑔𝜃⋅𝑑𝜃 ⟩↿⇂; third law: Wavelength = (2/𝑛)L, frequency = n𝑓0 . The Schrödinger equation has only quantized energy but still hasn’t quantized time thus inducing quantum collapse. We then conjugate inversion energy with quantizing time which composes of event inversion superposition to establish entropy-control lifespan for bio-systems. Originating from the gravitational folding of surface tension regions, bio quantum path duality fluctuation scales as macrocosmic elastic quantum ranges from a codon to the spinal size drives life folding or evolution. The biological functions including consciousness revive from the bio quantum path duality that modulates by the three modified laws.
A FHIR® has been lit on gICS® – Facilitating the standardized exchange of informed consents in a large network of university medicine (NUM) in pandemic research
Authors: Bialke Martin , Geidel Lars , Hampf Christopher , Blumentritt Arne , Penndorf Peter , Schuldt Ronny , Moser Frank-Michael , Lang Stefan , Werner Patrick , Stäubert Sebastian , Hund Hauke , Albashiti Fady , Gührer Jürgen , Prokosch Hans-Ulrich , Bahls Thomas , Hoffmann Wolfgang 
Published: September 2022

Abstract
Background

The Federal Ministry of Education and Research (BMBF) funds a network of university medicines (NUM) to support COVID-19 and pandemic research at national level. The “COVID-19 Data Exchange Platform” (CODEX) as part of NUM establishes a harmonised infrastructure that supports decentral but standardised provision as well as federated combination and research use of COVID-19 datasets. The broad consent (BC) of the Medical Informatics Initiative (MII) is agreed by all German federal states and forms the legal base for such data processing. All 34 participating university hospitals (NUM sites) work upon a harmonised infrastructural as well as legal basis for their data protection-compliant collection and transfer of their research dataset to the central CODEX platform.

Each NUM site ensures that the exchanged consent information conforms to the already-balloted HL7® FHIR® consent profiles and the interoperability concept of the MII Task Force “Consent Implementation” (TFCI).

The Independent Trusted Third-Party (TTP) of the University Medicine Greifswald successfully supports data protection-compliant data processing in various research projects since 2014 and provides the consent management solutions gICS®, which supports fully digital and paper-based consent management.

Results

A “TTP-FHIR Gateway” for the HL7® FHIR®-compliant exchange of consent information using gICS® throughout NUM-CODEX was implemented and provided to all NUM sites in June 2021 as a separate software component. The gateway relies on the gICS® application logic. All FHIR® functionalities comply with the already-balloted FHIR® consent profiles of the HL7® Working Group Consent Management.

A pre-configured consent template for the BC is provided to all NUM sites, thereby simplifying the technical BC rollout and the corresponding implementation of the TFCI interoperability concept at the NUM sites.

Conclusions

This article proves that a HL7® FHIR®-compliant and interoperable nationwide exchange of consent information could be built using of the consent management software gICS® and the provided TTP-FHIR Gateway. The initial functional scope of the solution covers the requirements identified in the NUM-CODEX setting. The semantic correctness of these functionalities was validated by project-partners from the Ludwig-Maximilian University in Munich. The production rollout of the solution package to all NUM sites has started successfully.
Health risk assessment of fluoride exposure due to groundwater consumption in Romania
Authors: Dobrinas Simona , Soceanu Alina , Manea Natalia , Sirbu Anca , Dumitrescu Corina Ionela , Popescu Viorica , Birghila Semaghiul , Matei Nicoleta , Popovici Ionela Carazeanu 
Published: September 2022

Abstract
Fluoride has both beneficial and detrimental effects on human health. Concentrations of fluoride less than 1.0 mg/L in ingested water are beneficial for the rate of tooth decay, especially in children. The aims of the paper are as follows: (i) to monitor fluoride concentrations in drinking water samples (well water and tap water from the rural district of Valea Râmnicului, Romania); (ii) to study and select the optimal buffer solution and the optimal volume used in the analyses and (iii) to validate the potentiometric method for determining fluoride ions with a selective ion electrode. The values of fluoride ion concentrations in the groundwater samples and in tap water varied from 0.01 to 0.138 mg/L. The values for the hazard quotient for the studied samples varied from 0.01 to 0.13.
Study on sustainable development and construction of karst mountain city based on the concept of a sponge city
Authors: Li Yue , Geng Huacai 
Published: September 2022

Abstract
In recent years, there has been rapid urbanization development in China. The rapid expansion of cities and the increase in the proportion of the area of impervious surfaces have caused urban flooding problems. The karst area in Southwest China is characterized by a sensitive ecosystem, poor self recovery ability and typical karst development. The problems of a fragile and imbalanced water ecology are particularly prominent in karst areas, making it necessary to explore the applicability of the concept of sponge cities in such environments. This study reviews the technical ideas, methods and concepts of sponge cities in China and abroad in recent years. Guiyang, a typical karst mountain city in China, was taken as an example in this study. This was because Guiyang has special hydrogeological characteristics as well as the current urbanization development processes that are affecting the water resources and the environment in the region. It is believed that the construction of mountain sponge cities in karst areas should be mainly through source reduction, process control and end management, combined with intelligent construction methods. Focus should be on strengthening the prevention and control of soil erosion in key areas and risk areas and on properly handling the relationship between urban construction and water resources and ecological environment protection.
Contribuições científicas da área da Vida e Meio Ambiente para a RevUergs (2015-2022)
Authors: De Castro Biane , De Lara Daniela Mueller , Lemos Dellins Mestreti 
Published: September 2022

Desde a sua criação em 2015 (Resolução Consun Nº 012/2015 revogada e substituída pela Resolução Conepe Nº 027/2021), a Revista Eletrônica Científica da Uergs (RevUergs) tem como objetivo o estímulo ao debate e à reflexão na indissociabilidade do ensino, pesquisa e extensão, fortalecendo as ciências, as letras e as artes por meio do intercâmbio de ideias, práticas e resultados. A Revista Eletrônica Científica da UERGS tem caráter interdisciplinar e / ou multidisciplinar, com publicações nas áreas de humanas e artes, exatas e engenharias e vida e meio ambiente, de forma a contribuir para o desenvolvimento da ciência e da extensão no Brasil e no exterior.
Em todos esses anos, a participação na área das ciências da vida e meio ambiente foi evidentemente comprovada através das diversas publicações realizadas. Estima-se que aproximadamente 66 % do total de artigos publicados foi relacionado às áreas das ciências agrárias e ambientais.
Tais publicações retratam a importância e a inserção de ações de pesquisa e extensão, incluindo a ciência e a tecnologia de modo interdisciplinar, desenvolvidas e fomentadas por diversas instituições (WU et al., 2019; MILANI et al., 2022; GONÇALVES; ROTH, 2022). Ainda, estas ações se destacam pela sua afinidade com os Objetivos de Desenvolvimento Sustentável (ODS), conduzindo o debate e a prática da formação de lideranças interdisciplinares com diferentes atores sociais para o avanço da implementação dos ODS (AVELAR et al., 2019).
Destaca-se que o trabalho com maior download em todos os anos de existência da RevUergs foi o resumo expandido, dos autores Barbosa et al. (2017), publicado na edição especial do 3° Simpósio de Gestão Ambiental: Territórios Hídricos e Mercados Ambientais da UERGS, intitulado como “As abelhas e seu serviço ecossistêmico de polinização”. Ainda merecem destaque quanto aos acessos e downloads, os artigos “O declínio populacional das abelhas: causas, potenciais soluções e perspectivas futuras”, dos autores Beringer et al. (2019) e “Diversidade e potencial de utilização de plantas alimentícias não convencionais no Vale do Taquari, RS”, dos autores Biondo et al. (2018). Tais publicações retratam o reconhecimento pelos leitores acerca da relevância desses trabalhos multidisciplinares dentro da área da vida e meio ambiente.
Desejamos uma ótima leitura a todos!
Antibacterial Polyacrylamide and Dextran-Graft-Polyacrylamide Hydrogels for the Treatment of Open Wounds
Authors: Virych Pavlo , Nadtoka Oksana , Kutsevol Nataliya , Krysa Bohdan , Krysa Vasyl 
Published: September 2022

Background. Open wound treatment requires a use of bandage material to prevent the development of pathogenic microflora and to provide the necessary conditions for tissue regeneration.
The aim of the study was to compare the effectiveness of polyacrylamide (PAA) and dextran-graft-polyacrylamide (D-PAA) hydrogels loaded with silver nanoparticles (AgNPs), antibiotics, and photosensitizers for the treatment of bacterial infection of open wounds.
Materials and Methods. PAA and D-PAA hydrogels with AgNPs, methylene blue (0.001%) without (MB) and with red light irradiation (660 nm) (MB+L), chlorhexidine (0.05%) and cefuroxime (0.1%) were used. There were tested in vitro and in vivo (a rat model) antibacterial activities against wild-type Staphylococcus aureus, Escherichia coli, antibiotic-resistant Escherichia coli and Klebsiella pneumoniae strains obtained from the wound. Clinical investigations were performed in patients with chronic venous ulcers of the lower extremities with no response to traditional treatments.
Results. S. aureus, E. coli, and K. pneumoniae strains were sensitive to PAA and D-PAA hydrogels with AgNPs, chlorhexidine, and cefuroxime. Antibiotic-resistant E. coli was not inhibited by the hydrogels with cefuroxime. This strain was less sensitive to chlorhexidine and MB+L. There were no differences between unloaded PAA and D-PAA hydrogels; the antibacterial properties of the dressing were determined by an antibacterial component loaded into the hydrogel. The use of unloaded D-PAA hydrogels in vivo helped reduce the size of the wound by 28.6% and 42.8% three and five days after wound modeling, respectively. Similar results were obtained for D-PAA hydrogels loaded with cefuroxime, chlorhexidine, and MB+L. D-PAA hydrogel with AgNPs reduced wound size by 50% and 62.5% three and five days after wound induction, respectively, demonstrated greater antibacterial activity and was selected for clinical investigations. In a patient, 14 days after bandage application, the fibrin membrane disappeared, the ulcers were covered with pink granulations, marginal epithelialization appeared.
Conclusions. PAA and D-PAA hydrogels can be loaded with the antibacterial compounds of various types. The type of polymer does not affect the antibacterial properties of the final hydrogels. The hydrogels with chlorhexidine and MB+L can be potentially used to treat bacterial contamination of wounds and ulcers. Nevertheless, their disadvantage is the inability to absorb or precipitate tissue breakdown products that interfere with normal regeneration and inflammation. D-PAA/AgNPs are the best option for treating ulcers due to the ability to control the properties of the hydrogels and nanoparticles, as well as multiple mechanisms of antibacterial action.
Measurement of Heart Rate Using the Withings ScanWatch Device During Free-living Activities: Validation Study
Authors: Giggins Oonagh M , Doyle Julie , Smith Suzanne , Crabtree Daniel R , Fraser Matthew 
Published: September 2022

Background
Wrist-worn devices that incorporate photoplethysmography (PPG) sensing represent an exciting means of measuring heart rate (HR). A number of studies have evaluated the accuracy of HR measurements produced by these devices in controlled laboratory environments. However, it is also important to establish the accuracy of measurements produced by these devices outside the laboratory, in real-world, consumer use conditions.

Objective
This study sought to examine the accuracy of HR measurements produced by the Withings ScanWatch during free-living activities.

Methods
A sample of convenience of 7 participants volunteered (3 male and 4 female; mean age 64, SD 10 years; mean height 164, SD 4 cm; mean weight 77, SD 16 kg) to take part in this real-world validation study. Participants were instructed to wear the ScanWatch for a 12-hour period on their nondominant wrist as they went about their day-to-day activities. A Polar H10 heart rate sensor was used as the criterion measure of HR. Participants used a study diary to document activities undertaken during the 12-hour study period. These activities were classified according to the 11 following domains: desk work, eat or drink, exercise, gardening, household activities, self-care, shopping, sitting, sleep, travel, and walking. Validity was assessed using the Bland-Altman analysis, concordance correlation coefficient (CCC), and mean absolute percentage error (MAPE).

Results
Across all activity domains, the ScanWatch measured HR with MAPE values <10%, except for the shopping activity domain (MAPE=10.8%). The activity domains that were more sedentary in nature (eg, desk work, eat or drink, and sitting) produced the most accurate HR measurements with a small mean bias and MAPE values <5%. Moderate to strong correlations (CCC=0.526-0.783) were observed between devices for all activity domains, except during the walking activity domain, which demonstrated a weak correlation (CCC=0.164) between devices.

Conclusions
The results of this study show that the ScanWatch measures HR with a degree of accuracy that is acceptable for general consumer use; however, it would not be suitable in circumstances where more accurate measurements of HR are required, such as in health care or in clinical trials. Overall, the ScanWatch was less accurate at measuring HR during ambulatory activities (eg, walking, gardening, and household activities) compared to more sedentary activities (eg, desk work, eat or drink, and sitting). Further larger-scale studies examining this device in different populations and during different activities are required.
Analysis of Pierce's Semiotic Perspective in the Terminology of Nahwu
Authors: Sopian Asep , Zakiah Ucu Siti Shafa , Abdulkhaleq Al-Rawafi 
Published: September 2022

This research is motivated by many Arabic Language students who only understand the terms of grammatical function in Nahwu, yet not with the essence of its meaning. Therefore, this research researches one of the books in the past - that keeps much secret knowledge - with semiotic studies as part of the linguistic form and educational value analysis. The purpose of the research is to recognize the icons, indexes, and symbols that had been used by Imam Ibnu Ajibah as the interpretation of terms in Nahwu and to know the value of education in this book. The research method that is used is qualitative descriptive with Pierce semiotic approach and literature review technique for research data collection. This research's primary data source is from Al-Futuhaat Al-Quddusiyah Fi Syarhi Muqaddimati Al-Jurumiyyah book created by Imam Ibnu Ajibah. The result of this research shows that there are two icons in the book: Tasawuf/Sufism (teachings on how to get closer to Allah and be united with Him) expert and the second one is what Sufi people do. Three indexes are also recognized: the speaking behavior index, behavior of a Salik index, and jihad behavior index. The six symbols inside the book are the Asma Allah symbol, the procedure of the Wushul symbol, the Ma'rifat symbol, the saints' oath symbol, the Jihad symbol, and the unseen symbol. The value of education in the book includes tawhid education values - which are Rububiyyah Tawhid and Asma wa Sifat Tawhid - and moral education values - which are morals towards Allah, Rasulullah, and morals towards human beings in their personal and social environment state-.
Cystic fibrosis-related mortality trends in Mexico between 1999 -- 2020
Authors: Bustamante Adriana , Fernandez Lucia , Rivas Lissette , Longoria Roberto Mercado 
Published: September 2022

Background. Cystic fibrosis (CF) is an autosomal recessive
disorder associated with an increased susceptibility to respiratory
infections that cause progressive decline in lung function and lead to
lung damage and chronic respiratory failure. To analyze the CF-related
mortality trends in the Mexican population during a 22-year period. We
conducted a mortality trend analysis using death certificates data.
Trends in CF-specific and in age-specific mortality rates were evaluated
using Joinpoint regression analysis. Among subjects ≤40 years, 1184
CF-related deaths were identified. In 1999–2009 median age at death was
7 years compared to 10 years in 2010–2020. Overall mortality rate
increased from 0.03 per 100,000 in 1999 to 0.06 per 100,000 in 2020. A
decline in mortality rate for patients ≤28 days and an increase in
mortality rate in older age groups was observed. Conclusion.
The increasing trend in overall mortality, associated with a downward
trend in neonatal mortality and an increase in median age at death is
conceivably due to enhanced diagnosis, as well as major advances in
treatment modalities, leading to higher survival rates. Key
words: age at death, cystic fibrosis, epidemiology, low- and
middle-income countries, mortality, survival rate.