bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence, prevalence, and outcome of moderate to severe neurotrophic keratopathy in a German tertiary referral center from 2013 to 2017
Authors: Roth Mathias , Dierse Sebastian , Alder Jan , Holtmann Christoph , Geerling Gerd 
Published: January 2022

Abstract
Background
Neurotrophic keratopathy (NK) is an orphan disease, with an estimated prevalence of 1–5/10,000. No data regarding the incidence exists. The primary aim was to evaluate incidence and prevalence of NK at a tertiary referral center in Germany, and the secondary aim was to analyze demographic parameters, etiology, and clinical features and therapeutic outcomes.

Methods and material
All patients treated for NK with serum eye drops (SED), amnionic membrane transplantation (AMT), or penetrating keratoplasty (PK) in 2013–2017 were identified. Age, sex, etiology of NK, visual acuity, disease stage, treatment, and visual acuity were analyzed. Incidence and prevalence of NK in our hospital and the overall population of the city were calculated.

Results
In 63 eyes of 60 patients (56.7% male; 68 ± 16 years), the most common underlying diseases were herpetic infections (23.8%), neurological causes (19%), and diabetes mellitus (14.3%). The annual incidence of NK in our tertiary referral center ranges between 5/10,000 and 3/10,000, the prevalence between 9/10,00 and 22/10,000. In all patients treated with corneal ulcers, the prevalence was up to 27% (2706/10,000). The incidence in the overall population is estimated at 0.1–0.3/10,000, the prevalence at 0.2–0.5/10,000 to 0.5/10,000.

Conclusion
Based on our assessment, the prevalence of NK in the overall population is lower than estimated before. However, in patients with corneal ulcers, the percentage of NK is comparably high. The disease may still be underdiagnosed due to the variety of underlying disorders and unknown comorbidities. Thus, in cases of therapy-refractive superficial keratopathy or ulcerations, NK should be considered more frequently.
Interpretable generative deep learning: an illustration with single cell gene expression data
Authors: Treppner Martin , Binder Harald , Hess Moritz 
Published: January 2022

AbstractDeep generative models can learn the underlying structure, such as pathways or gene programs, from omics data. We provide an introduction as well as an overview of such techniques, specifically illustrating their use with single-cell gene expression data. For example, the low dimensional latent representations offered by various approaches, such as variational auto-encoders, are useful to get a better understanding of the relations between observed gene expressions and experimental factors or phenotypes. Furthermore, by providing a generative model for the latent and observed variables, deep generative models can generate synthetic observations, which allow us to assess the uncertainty in the learned representations. While deep generative models are useful to learn the structure of high-dimensional omics data by efficiently capturing non-linear dependencies between genes, they are sometimes difficult to interpret due to their neural network building blocks. More precisely, to understand the relationship between learned latent variables and observed variables, e.g., gene transcript abundances and external phenotypes, is difficult. Therefore, we also illustrate current approaches that allow us to infer the relationship between learned latent variables and observed variables as well as external phenotypes. Thereby, we render deep learning approaches more interpretable. In an application with single-cell gene expression data, we demonstrate the utility of the discussed methods.
Oral health–related quality of life (OHRQOL) of preschool children’s anterior teeth restored with zirconia crowns versus resin-bonded composite strip crowns: a 12-month prospective clinical trial
Authors: Elheeny Ahmad Abdel Hamid , Abdelmotelb Mahmoud Ahmed 
Published: January 2022

Abstract
Objectives
To compare oral health–related quality of Life (OHRQOL) of preschool children’s anterior teeth restored with prefabricated zirconia crowns (ZC) versus resin-bonded composite strip crown (RCSC).

Materials and methods
A prospective clinical trial included 136 children with early childhood caries aged 36–71 months who were assigned into prefabricated ZC and RCSC groups. A total of 344 teeth were restored either with 170 ZCs (49.4%) and 174 RCSCs (50.6%). Wilson and Cleary’s conceptual model was to associate the study predictors to the OHRQOL. Early Childhood Oral Health Impact Scale (ECOHIS) was used to assess the OHRQOL at 6 and 12 months. Mann–Whitney U test was used in comparing OHRQOL mean scores in the two groups and Wilcoxon signed-rank test with the effect size (r) to measure the intragroup OHRQOL change. A Poisson regression model was used to study potential risk factors associated with the overall OHRQOL.

Results
After 12 months, the USPHS parameters of the ZC were significantly superior compared to the RCSC. Overall ECOHIS mean scores in the ZC group were significantly lower than that of the RCSC group at T1 and T2 (p < 0.001). Remarkable enhancement of the OHRQOL at the follow-ups with a large effect size (r < 0.8) was observed. Restoration type, retention, baseline OHRQOL, and color had a significant impact on the overall OHRQOL at 12 months.

Conclusions
Preschool children OHRQOL treated with ZC were significantly better than those who received RCSC.

Clinical relevance
One of the optimum treatment standards in pediatric dentistry is the esthetic demand which has significance on the child’s OHRQOL and subsequently child’s general health quality of life. It is beneficial to the dentist to identify the influence of esthetic restorations on the OHRQOL of preschool children which aids in future decision-making. The longitudinal nature of the study enables the dentist to identify the changes of children’s OHRQOL.
Tackling the rich vehicle routing problem with nature-inspired algorithms
Authors: Lesch Veronika , König Maximilian , Kounev Samuel , Stein Anthony , Krupitzer Christian 
Published: January 2022

AbstractIn the last decades, the classical Vehicle Routing Problem (VRP), i.e., assigning a set of orders to vehicles and planning their routes has been intensively researched. As only the assignment of order to vehicles and their routes is already an NP-complete problem, the application of these algorithms in practice often fails to take into account the constraints and restrictions that apply in real-world applications, the so called rich VRP (rVRP) and are limited to single aspects. In this work, we incorporate the main relevant real-world constraints and requirements. We propose a two-stage strategy and a Timeline algorithm for time windows and pause times, and apply a Genetic Algorithm (GA) and Ant Colony Optimization (ACO) individually to the problem to find optimal solutions. Our evaluation of eight different problem instances against four state-of-the-art algorithms shows that our approach handles all given constraints in a reasonable time.
Introducing Parenting Support in Primary Care: Professionals’ Perspectives on the Implementation of a Positive Parenting Program
Authors: Callejas Enrique , Byrne Sonia , Rodrigo María José 
Published: January 2022

AbstractWhile positive parenting programs are an initiative aligned with the Family-Centered Care model and the Council of Europe’s Recommendation on Positive Parenting, implementation in healthcare centers remains a challenge. The aims of this study were to (1) investigate how the hybrid version (online course plus face-to-face activities) of the program “Gain Health & Wellbeing From 0 to 3” was implemented in Spain from professionals’ perspective, and (2) explore the perceived impact of this hybrid version of the program on the implementers’ professional development. We used a qualitative mixed-methods design that included focus groups and surveys. Fifty professionals from 17 centers completed the survey on professional development. Thirty-one of these also participated in the focus groups to address the first aim. The key themes identified from the focus group were professional training, parent recruitment, program features, organizational issues, parental responses, and program sustainability. Survey results related to positive professional impact fit nicely with subthemes concerning collaboration with parents, parental needs, center coordination, and future expectations. The perceived relevance of the parenting program and its positive impact on the implementers’ professional development were potential predictors for the adoption and sustainability of the program in the public health system.
Entrapment, temptation and virtue testing
Authors: Hill Daniel J. , McLeod Stephen K. , Tanyi Attila 
Published: January 2022

AbstractWe address the ethics of scenarios in which one party (the ‘agent’) entraps, intentionally tempts or intentionally tests the virtue of another (the ‘target’). We classify, in a new manner, three distinct types of acts that are of concern, namely acts of entrapment, of (mere) intentional temptation and of (mere) virtue testing. Our classification is, for each kind of scenario, of itself neutral concerning the question whether the agent acts permissibly (and concerning the extent to which the target is culpable). We explain why acts of entrapment are more ethically objectionable than like acts of (mere) intentional temptation and why these, in turn, are more ethically objectionable than like acts of (mere) virtue testing. Along the way, we scrutinize, and eventually reject, the view that acts of entrapment are ethically unacceptable because intentional temptation is involved in entrapment. (The article touches upon, but is not about, the question of culpability.)
A qualitative assessment of QCA: method stretching in large-N studies and temporality
Authors: Finn Victoria 
Published: January 2022

AbstractQualitative Comparative Analysis (QCA) is a descriptive research method that can provide causal explanations for an outcome of interest. Despite extensive quantitative assessments of the method, my objective is to contribute to the scholarly discussion with insights constructed through a qualitative lens. Researchers using the QCA approach have less ability to incorporate and nuance information on set membership as the number of cases grows. While recognizing the suggested ways to overcome such challenges, I argue that since setting criteria for membership, calibrating, and categorizing are crucial QCA aspects that require in-depth knowledge, QCA is unfit for larger-N studies. Additionally, I also discuss that while the method is able to identify various parts of a causal configuration—the ‘what’—it falls short to shed light on the ‘how’ and ‘why,’ especially when temporality matters. Researchers can complement it with other methods, such as process tracing and case studies, to fill in these missing explanatory pieces or clarify contradictions—which begs the question of why they would also choose to use QCA.
Soil and Leaf Mineral Element Contents in Mediterranean Vineyards: Bioaccumulation and Potential Soil Pollution
Authors: Jiménez-Ballesta R. , Bravo S. , Amorós J. A. , Pérez-de-los-Reyes C. , García-Pradas J. , Sanchez M. , García-Navarro F. J. 
Published: January 2022

Abstract
The study reported here concerns the geochemical distributions of macro- and trace elements (including potentially toxic elements, PTEs) in the vineyard soils of Alcubillas, which is one of the oldest, albeit not world-renowned, wine-growing areas in La Mancha (Central Spain). Soil and leaf samples were analyzed by X-ray fluorescence spectrometry to ascertain the levels of various elements in the soil and the plant. The potential toxicity of the elements was assessed with regard to the development of the vineyard. Despite the fact that fertilizers and pesticides are employed in the vineyards in this area, the results showed that the levels of trace elements in the soil samples did not exceed the reference values according the pedogeochemical values for the region and Spain. This finding suggests that the study area is not polluted, and therefore, there are hardly any traces of anthropogenic contamination. The Biological Absorption Coefficient (BAC) was calculated to assess the assimilation of various elements from the soil to the leaves, and differences were found in the element absorption capacity of the vines. Some elements were not taken up by Vitis vinifera despite elements like Zr and Rb being present in relatively high concentrations in the soil. The production in these soils does not represent a threat to human health or the ecosystem, because the farmers in this area are extremely careful to preserve the environment and they only farm to achieve moderate yields of grapes per hectare.
Variability in Carcinus maenas Fecundity Along Lagoons and Estuaries of the Portuguese Coast
Authors: Monteiro João N. , Ovelheiro Andreia , Ventaneira Ana M. , Vieira Vasco , Teodósio Maria Alexandra , Leitão Francisco 
Published: January 2022

AbstractAlthough Carcinus maenas as a species is widely studied, research focusing on fecundity is still scarce. The main objective of this study was to evaluate size-fecundity relationships across different lagoons and estuaries, along the Portuguese coast, to understand how the local environment affects reproductive patterns. Between 2019 and 2020, ovigerous females were collected from the Southern (Ria Formosa and Ria de Alvor), Central (Rio Sado) and Northern regions (Ria de Aveiro) of Portugal, and the fecundity of each female was estimated by counting and weighing eggs. Morphometric relationships (carapace width–egg counting; egg counting–egg weight; body wet weight–egg weight; carapace width–body wet weight) were inferred from 180 egg-bearing females with a carapace width between 26.96 and 61.25 mm. A positive correlation between fecundity and the morphological parameters was observed. Differences in fecundity were found among all systems, from northern to southern Portugal, varying between 22121 and 408538 eggs per female. Furthermore, a regional gradient was observed across regions, with lower temperature estuaries (Ria de Aveiro) displaying an increase in fecundity. The fecundity in Rio Sado was also affected by salinity. Fecundity differences across regions were associated with hydrodynamics, temperature, and salinity differences among systems. No statistically significant differences were observed between Carapace Width—Body Wet Weight regressions performed in each studied system, indicating that, contrary to fecundity, the somatic growth of C. maenas is not affected by latitudinal or environmental conditions.
Ferulic Acid Alleviates Atherosclerotic Plaques by Inhibiting VSMC Proliferation Through the NO/p21 Signaling pathway
Authors: Wu Xiaoyun , Hu Ziwei , Zhou Junjie , Liu Jin , Ren Ping , Huang Xi 
Published: January 2022

Abstract The benefits and risks of inhibiting the proliferation and migration of vascular smooth muscle cells (VSMCs) in atherosclerosis (AS) remain a subject of debate. In this study, we investigated the effect of ferulic acid (FA) on the proliferation and migration of VSMCs induced by platelet-derived growth factor (PDGF) and the associated mechanism and used ApoE-/- mice to study whether the effect of FA on VSMC proliferation and migration is beneficial in alleviating AS plaques. It was found that FA not only reduced blood lipid levels but also promoted the production of nitric oxide (NO) by MOVAS cells through the endothelial nitric oxide synthase (eNOS) pathway, inhibited the migration and proliferation of VSMCs induced by PDGF, promoted the expression of p21 in VSMCs, and exerted a therapeutic effect against AS.
The Futures of Europe: Society 5.0 and Industry 5.0 as Driving Forces of Future Universities
Authors: Carayannis Elias G. , Morawska-Jancelewicz Joanna 
Published: January 2022

AbstractThe concept of Society 5.0 and Industry 5.0 is not a simple chronological continuation or alternative to Industry 4.0 paradigm. Society 5.0 aims to place human beings at the midpoint of innovation, exploiting the impact of technology and Industry 4.0 results with the technological integration to improve quality of life, social responsibility and sustainability. This ground-breaking perspective has common points with the objectives of the United Nations Sustainable Development Goals. It also has major implication for universities transformations. Universities are called upon producing knowledge for new technologies and social innovation. In our paper, we argue that digitalisation opens new perspectives for universities and can become one of the main drivers of their change. Incorporating the assumptions of Society 5.0 and Industry 5.0 into the universities practices and policies will allow both universities and societies to fully benefit from digital transformation. Making the human-oriented innovation as the universities trademark and developing new cooperative models will also help to achieve sustainable priorities. The use of the Quintuple Helix Model (QHM) might foster the process of necessary transformations capacities as it integrates different perspectives and sets the stage for sustainability priorities and considerations. As far as the practical goal is concerned, the paper proposes a set of recommendations for universities aiming at developing new forms and channels of distribution of education, research and innovation within in the context of QHM and Society 5.0. We call them socially and digitally engaged model.
Endoscopic and Robotic Stapes Surgery: Review with Emphasis on Recent Surgical Refinements
Authors: Sheppard Sean C. , Caversaccio Marco D. , Anschuetz Lukas 
Published: January 2022

AbstractPurpose of ReviewStapes surgery has been established as the gold standard for surgical treatment of conductive hearing loss in otosclerosis. Excellent outcomes with very low complication rate are reported for this surgery. Recent advances to improve surgical outcome have modified the surgical technique with endoscopes, and recent studies report development of robotical assistance. This article reviews the use of endoscopes and robotical assistance for stapes surgery.Recent FindingsWhile different robotic models have been developed, 2 models for stapes surgery have been used in the clinical setting. These can be used concomitant to an endoscope or microscope. Endoscopes are used on a regular base regarding stapes surgery with similar outcomes as microscopes. Endoscopic stapes surgery shows similar audiological results to microscopic technique with an advantage of less postoperative dysgeusia and pain. Its utility in cases of revision surgery or malformation is emphasized.SummaryEndoscopic stapes surgery is used on a regular basis with excellent outcomes similar to the microscopic approach, while reducing surgical morbidity. Robotic technology is increasingly being developed in the experimental setting, and first applications are reported in its clinical use.
Neurochemical and Hormonal Contributors to Compulsive Sexual Behavior Disorder
Authors: Chatzittofis Andreas , Boström Adrian Desai E. , Savard Josephine , Öberg Katarina Görts , Arver Stefan , Jokinen Jussi 
Published: January 2022

Abstract
Purpose of Review
Compulsive sexual behavior disorder has been recently included in the 11th revision of the International Classification of Diseases (ICD-11), and the possible contribution of neurochemical and hormonal factors have been reported. However, relatively little is known concerning the neurobiology underlying this disorder. The aim of this article is to review and discuss published findings in the area.

Recent Findings
Evidence suggests that the neuroendocrine systems are involved in the pathophysiology of compulsive sexual behavior. The hypothalamus-pituitary adrenal axis, the hypothalamus-pituitary–gonadal axis, and the oxytocinergic system have been implicated.

Summary
Further studies are needed to elucidate the exact involvement of neuroendocrine and hormonal systems in compulsive sexual behavior disorder. Prospective longitudinal studies are particularly needed, especially those considering co-occurring psychiatric disorders and obtaining hormonal assessments in experimental circumstances with appropriate control groups.
Structural Racism as an Environmental Justice Issue: A Multilevel Analysis of the State Racism Index and Environmental Health Risk from Air Toxics
Authors: Alvarez Camila H. 
Published: January 2022

AbstractCommunities of color and poor neighborhoods are disproportionately exposed to more air pollution—a pattern known as environmental injustices. Environmental injustices increase susceptibility to negative health outcomes among residents in affected communities. The structural mechanisms distributing environmental injustices in the USA are understudied. Bridging the literatures on the social determinants of health and environmental justice highlights the importance of the environmental conditions for health inequalities and sheds light on the institutional mechanisms driving environmental health inequalities. Employing a critical quantitative methods approach, we use data from an innovative state racism index to argue that systematic racialized inequalities in areas from housing to employment increase outdoor airborne environmental health risks in neighborhoods. Results of a multilevel analysis in over 65,000 census tracts demonstrate that tracts in states with higher levels of state-level Black–white gaps report greater environmental health risk exposure to outdoor air pollution. The state racism index explains four-to-ten percent of county- and state-level variation in carcinogenic risk and noncarcinogenic respiratory system risks from outdoor air toxics. The findings suggest that the disproportional exposure across communities is tied to systematic inequalities in environmental regulation and other structural elements such as housing and incarceration. Structural racism is an environmental justice issue.
NETME: on-the-fly knowledge network construction from biomedical literature
Authors: Muscolino Alessandro , Di Maria Antonio , Rapicavoli Rosaria Valentina , Alaimo Salvatore , Bellomo Lorenzo , Billeci Fabrizio , Borzì Stefano , Ferragina Paolo , Ferro Alfredo , Pulvirenti Alfredo 
Published: January 2022

Abstract
Background
The rapidly increasing biological literature is a key resource to automatically extract and gain knowledge concerning biological elements and their relations. Knowledge Networks are helpful tools in the context of biological knowledge discovery and modeling.

Results
We introduce a novel system called NETME, which, starting from a set of full-texts obtained from PubMed, through an easy-to-use web interface, interactively extracts biological elements from ontological databases and then synthesizes a network inferring relations among such elements. The results clearly show that our tool is capable of inferring comprehensive and reliable biological networks.