bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of SARS-CoV-2 PCR positivity in UK Fenland study participants using smartphone-submitted vital sign measurements
Authors: Moore Alex , Dolezalova Nikola , Morelli Davide , Gkrania-Klotsas Effrossyni , Cunningham Adam , Booth Adam , Plans David , Reed Angus , Aral Mert , Rennie Kirsten , Wareham Nick 
Published: August 2022

Abstract
IntroductionMobile health applications are increasingly being used in health and clinical research. SARS-CoV-2 has proven to have high infectivity, making outbreaks difficult to contain. Early detection can help prevent spread, but there is a need to develop easy-to-use screening tools that can help identify potential infection as early as possible. Here, we describe the development of a machine learning classifier that can predict SARS-CoV-2 PCR positivity using smartphone-submitted vital sign measurements.MethodsThe Fenland App study followed 2,199 UK participants using a smartphone application from August 2020 and for a minimum of six months. Participants completed a baseline questionnaire and then monthly questionnaires about SARS-CoV-2 status and vaccinations. Three times a week, participants provided measurements of their blood oxygen saturation, body temperature, and resting heart rate via a pulse oximeter, digital thermometer, and their smartphone. The participants participated in self initiated SARS-CoV-2 testing as per concurrent public health guidelines.We built predictive models SARS-CoV-2 PCR positivity status as obtained from national surveillance PCR test results.ResultsA total of 77 positive and 6,339 negative SARS-CoV-2 tests were recorded during the study. The final model achieved an ROC AUC of 0.695 ± 0.045. There was no difference in model performance when using 4, 8 or 12 weeks of baseline data before a SARS-CoV-2 test (F(2) = 0.80, p = 0.472). Addition of demographic or symptom information had no impact on model performance.ConclusionsUsing only three smartphone collected vital sign measurements, it is possible to predict SARS-CoV-2 PCR positivity, using a four week baseline period. Smartphone based remote monitoring of patient vital signs could allow for earlier screening for potential infections. This method could be applicable to any infectious disease that causes physiological changes in vital signs.
Adjusting the RAPID score with 3 additional variables significantly increases its predictive value in patients with empyema
Authors: Stüben Björn-Ole , Plitzko Gabriel Andreas , Urban Franca , Kölzer Hannah , Kemper Marius , Wakker Jonas , Izbicki Jakob Robert , Bachmann Kai 
Published: August 2022

Abstract
BackgroundPleural empyema is a serious condition leading to a significant burden on health care systems due to protracted hospitalisations. Treatment ranges from non-surgical interventions such as antibiotic therapy and chest tube placement to thoracoscopic or open surgery. Various risk factors which impact outcomes have been investigated. The RAPID (renal, age, purulence, infection source, and dietary factors) score is a clinical risk score which identifies patients at risk of death and may be used to formulate individual treatment strategies accordingly. All patients undergoing surgical interventions for empyema at a major tertiary medical center in Germany from 2017-2020 were analysed. The aim was to identify perioperative risk factors which significantly impact treatment outcomes but are currently not included in the RAPID score. Methods245 patients with pleural empyema treated at the Department of General, Visceral and Thoracic Surgery at the University Medical Center, Hamburg, Germany (admitted from January 2017 to April 2020) were retrospectively analysed. All patients which received either minimally invasive or open thoracic surgery were included. Epidemiological as well as perioperative data was analysed to identify risk factors which impact long-term overall outcomes. 90-day mortality rate was the primary endpoint. Postoperative morbidity and length of hospital stay (LOS) were also investigated.ResultsThe mean age was 59.4 years with a bimodal distribution. There was a male predominance across the cohort (71.4% compared to 28.6%), with no significant differences across ages below or above 60 years. 53 (21.6%) patients died within the first 90 days. Diabetes type 1 and 2, renal insufficiency, immunosuppression, postoperative bleeding, intraoperative transfusion as well as microbiologically confirmed bacterial invasion of the pleura all led to higher mortality rates. Higher RAPID scores accurately predicted higher 90-day mortality rates. Modifying the RAPID score by adding the comorbidities diabetes, renal insufficiency and immunosuppression significantly increased the predictive value.ConclusionsWe demonstrated various perioperative and intraoperative risk-factors not included in the RAPID score which negatively impact postoperative outcome in patients receiving surgical treatment for pleural empyema. These should be taken into consideration when deciding on the best course of treatment. If confirmed in a prospective study with a significantly larger cohort, it may be worth considering expanding the RAPID score to include these.
Parasomnias manifest different phenotypes in age- and sex-groups. An internet-based video research
Authors: Corrêa Vivian M. , Vitrai József , Szűcs Anna 
Published: August 2022

Abstract
Hypothesis There are typical patterns - phenotypes - of sleep behaviors characterizing age-, and sex-groups of parasomnia patients. Materials and methods We analyzed sleep-related behaviors likely representing parasomnias, looking for phenotypes in different groups. We searched public internet databases using the keywords “sleepwalking”, “sleep eating” “sleep sex”, “sleep talking”, “aggression in sleep” and somnambulism in six languages. Poor-quality vide-records and those showing apparently faked sleep behaviors were excluded. We classified those persons shown on the videos into estimated sex- and age (children, adults, elderly) - groups; scored the activity types by a self-made scoring scale; and applied binary logistic regression for analyzing the association between sleep behaviors versus sex- and age- groups by STATA package providing 95% confidence interval and the probability of statistical significance.Results Twohundred-twentyfour videos (102 women) were analyzed. The odds of sleepwalking and related dangerous behaviors were lower in the elderly than in adults (P<0.025). Females performed complex risky behaviors during sleepwalking more often than males (P<0.012). Elderly people presented emotional behaviors less frequently than adults (P<0.004), and females showed them twice often as males. Adults sleep talked full sentences more often than children and elderly people (P<0.001). Elderly males had 40-fold odds compared to adults and children, to perform aggressive movements, and 70-fold odds of complex movements in the bed, compared to adults.Conclusion Elderly people rarely sleepwalk in our research. Elderly males perform intense and violent movements in bed, unlike other groups. The existence of parasomnia phenotypes allows prevention of injury types and raises theoretical questions on the mechanism including social and brain-network features of parasomnias.
Research on Implicit Intent Recognition Method Based on Prompt Learning
Authors: Liu Shuhua , Li Lanting , Fang Ming , Hung Chih-Cheng , Yang Shihao 
Published: August 2022

Abstract
As one of the core modules of the dialogue system, intent recognition plays an important role in human-computer interaction. Most of the existing intent recognition research is limited to simple, direct, and explicit intent recognitions. However, the natural human-computer interactions are flexible and diverse, and the expressions are often the euphemistic implicit intentions. Therefore, the implicit intent recognition brings new research challenges in this field. This paper pioneers a Chinese Implicit Intent Dataset CIID, which covers 7 common intents from different fields, and the data is the text containing the user's implicit intent. Based on this corpus, it is the first time prompt learning is employed for implicit intent recognition and by constructing a suitable prompt template, the model can get "relevant hints" to dig out the true intention of the user. Finally, this paper evaluates a range of classification models on CIID dataset. Experimental results show that the recognition rate of the proposed model is 97.6%, and achieves the state-of-the-art recognition accuracy. Furthermore, since it is difficult to collect the user's implicit intention data, this paper also explores the performance of these classification models on the CIID dataset with few-shot settings, and the experimental results show when the training data is reduced to 4.7%, the recognition rate of the proposed model can still keep 92.4%, which is significantly higher than other baseline models, the results further prove this proposed method is advanced and robust.
GABRP is a potential chemoresistance regulator in colorectal cancer
Authors: tengyu wang , Zhen Qinghao , Wu Tong , Jin Lan , Yao Surui , Feng Yuyang , Chen Jinghua , Chen Chen , Huang Zhaohui 
Published: August 2022

Abstract
Background: Colorectal cancer (CRC) is one of the cancers with high morbidity and mortality worldwide. Chemotherapy is commonly used for metastatic or more advanced CRC. The mechanism of CRC chemoresistance is still under active investigation. Therefore, we identify and validate differentially expressed genes (DEGs) between oxaliplatin/5-FU resistant and sensitive cells.Methods and Results: Three datasets of colorectal cancer patients (GSE28691, GSE81006, and GSE77932) from Gene Expression Omnibus (GEO) database were analyzed and volcano plots for DEGs were generated using GEO2R tool. The intersection of three GEO datasets showed that GABRP was significantly upregulated in chemo-resistant CRC cells or patients with an adjusted p-value less than 0.01. The STRING website analyzed the potential protein-protein interaction (PPI) network with GABRP. The PPI network predicted ANKRD66, CLINT1, HAP1, PLCL1, GABARPAP, GABARAPL1, NSF, GABARAPL2, TRAK2, and CLIC3 had a high likelihood to interact with GABRP. Especially, GABARAP, GABARAPL1, ANKRD66, CLINT1, and CLIC3 were enriched as the most possible associated protein with GABRP among the networks. GABRP was significantly highly expressed in both oxaliplatin/5-FU resistant CRC cells than in those counterparts sensitive CRC cells using quantitative PCR (qPCR) analysis. Consistently, TCGA and oncomine database confirmed that high expression of GABRP in various cancer patients including CRC patients tends to have relatively lower survival and disease-free survival rate.Conclusion: We identify GABRP as a promising drug target to mediate oxaliplatin or 5-FU resistance in CRC. It provided the theoretical basis and potential clinical value for CRC patients.
Development of a simple standardized scoring system for assessing large vessel vasculitis by 18F-FDG PET-CT, and differentiation from atherosclerosis
Authors: Bacour Y.A.A. , Kanten M.P. van , Smit F. , Comans E.F.I. , Akarriou M. , de Vet H.C.W. , Voskuyl A.E. , Laken C.J. van der , Smulders Yvo 
Published: August 2022

Abstract
Purpose: to develop a structured approach to distinguishing large-artery vasculitis from atherosclerosis using 18-fluorodeoxyglucose positron emission tomography combined with low-dose computed tomography (FDG PET/CT).Methods: We evaluated the FDG PET/CT images of 60 patients, 30 having biopsy-proven giant cell arteritis (GCA; the most common form of large-artery vasculitis), and 30 with atherosclerosis. Twelve nuclear medicine physicians evaluated images using 5 criteria: FDG uptake pattern (intensity, distribution, circularity), the degree of calcification, and co-localization of calcifications with FDG-uptake. Criteria that passed agreement and reliability tests were subsequently analysed for accuracy using receiver operator curve (ROC) analyses. Criteria that showed discriminative ability were then combined in a multi-component scoring system. Observers also reported both initial and final ‘gestalt’ conclusion before and after detailed examination of the images. Results: Agreement and reliability analyses disqualified 3 of the 5 criteria, leaving only FDG uptake intensity and calcification for potential use in a scoring system. ROC analysis showed an area under the curve (AUC) of 0.90 (95%CI 0.87 - 0.92) for FDG uptake intensity. Degree of calcification showed poor discriminative ability on its own (AUC of 0.62 (95%CI 0.58 - 0.66). When combining presence of calcification with FDG uptake intensity into a 6-tiered scoring system, the AUC remained similar at 0.91 (95%CI 0.88-0.93). After exclusion of cases with arterial prostheses, the AUC increased to 0.93 (95%CI 0.91 - 0.95). The accuracy of the ‘gestalt’ conclusion was initially 89% (95%CI 86% - 91%) and increased to 93% (95%CI 91 - 95%) after detailed image examination. Conclusion: Standardised assessment of arterial wall FDG uptake intensity, preferably combined with assessment of arterial calcifications into a scoring method enables accurate distinction between large artery vasculitis and atherosclerosis.
Effects of a self-efficacy-centred self-management program on neurogenic bladder after spinal cord injury: a randomized controlled trial
Authors: Yu Zepeng , Tang xiangxiang , Huang Jin , Liu Qian , Wang Wenyan , Su Xiaoping 
Published: August 2022

Abstract
Study design:
A double-blinded randomized controlled trial.
Objective
The present research aimed to investigate the effects of a self-efficacy-centred self-management program on persons with neurogenic bladder (NGB) after spinal cord injury (SCI).
Setting:
The spinal surgery department of the Third Affiliated Hospital of Soochow University, Changzhou, China.
Methods
Eighty-two individuals with NGB after SCI were randomized into the control or intervention group. The control group received standard admission and discharge education and follow-up. The intervention group received the self-efficacy-centred self-management programme. Self-efficacy was assessed at preintervention, 4 weeks, 8 weeks and 12 weeks postintervention. Self-management ability, the incidence of UTI, residual urine volume, bladder safety capacity and quality of life were assessed at 12 weeks postintervention. The data obtained were analysed using SPSS 26.0.
Results
Ultimately, 79 participants (control group: n = 39, 66.67% males, intervention group: n = 40, 57.50% males) received the full intervention. A significant difference was observed in self-efficacy between the control and intervention groups (2.54 ± SD 0.247 versus 2.71 ± SD 0.218, mean 95% CI: 0.174, 0.070 to 0.278, p < 0.05) at 12 weeks postintervention. Significant differences (p < 0.05) were observed in self-management ability, the incidence of UTI, residual urine volume and bladder safety capacity between the groups at 12 weeks postintervention. There were significant differences in quality of life (vitality, mental health, p < 0.05) between the two groups.
Conclusions
The self-efficacy-centred self-management program developed in this study can significantly increase participants’ self-efficacy and bladder self-management ability, thereby improving their bladder functional status and quality of life.
Fixed-time adaptive fuzzy control for nonlinear interconnection high-order systems with unknown control direction
Authors: Bai Wen , Liu Peter Xiaoping , Wang Huanqing 
Published: August 2022

Abstract
This study investigates an adaptive fixed-time tracking problem of nonlinear interconnected high-order systems with unknown control direction and stochastic disturbances. By utilizing the Nussbaum gain technique, an adaptive fixed-time controller is proposed to overcome difficulties associated with unknown control directions. Under the framework of adaptive feedback, the backstepping method and fuzzy logic system are utilized to deal with the stochastic disturbances and the packaged unknown nonlinearities. Adding a power integrator is used within the adaptive backstepping control scheme to deal with the positive odd integer terms. The designed control strategy guarantees that the tracking error converges within a fixed settling time and all signals of the closed-loop system are fixed-time bounded. Simulation results validate the designed control approach.
A simple and efficient process for the synthesis of 2D carbon nitrides and related materials.
Authors: Huc Vincent , Silva Cora Moreira Da , Vallet Maxime , Saint-Martin Romuald , Leroy Jocelyne , Dragoé; Diana , semion clément , Brisset François , Blin Thomas , guillot regis , Gillet Cynthia 
Published: August 2022

Abstract
This manuscript describes a new process for the synthesis of very high quality 2D Covalent Organic Frameworks (COFs), such a C2N and CN carbon nitrides. The structure/quality of these materials is demonstrated by extensive cross-characterisations at different scales. The availability of such very large, high quality layers of these materials opens interesting perspectives, for example in photochemistry and electronics (intrinsic transport properties, high gap substrate for graphene, etc...). We thus consider that this work could be of interest to a broad readership, considering that this topic is among the current hottest ones.
A case of pulmonary Sequestration with blood supply from lar ge aorta treated by thoracoscopic surgery
Authors: Chen Jian , Hu Jiangwei , He Junming , Fu Yin , Guan Wei , Lou Guoliang 
Published: August 2022

Abstract
Pulmonary Sequestration (PS) is a rare congenital lung disease in which the fetal part of the lung tissue separates from the main part of the pulmonary lung tissue, the separate development form does not have lung function and accepts systemic arterial blood supply of cystic masses, clinically mostly asymptomatic. However, due to the risk of infection and cancer, surgical removal of the current is still the preferred treatment for the disease. Thoracoscopic and direct thoracotomy are both feasible treatment options. Despite the fact the isolation vessel in this case was unusually thick, the surgery was successful, confirming that thoracoscopic surgery remains safe and effective.
FTO deubiquitinated by USP7 influenced NEDD4 mRNA stability enhancing the chemoresistance of pancreatic cancer to gemcitabine by promoting cell proliferation and upregulating RRM1 expression
Authors: Lin Kai , Zhou Endi , Zheng Ziruo , Zhang Siqing , Shi Ting , Yang Chaozhi , Zhang Guodong , Cai Jingsheng , Gao Wentao 
Published: August 2022

Abstract
Background: Pancreatic cancer is the seventh leading cause of cancer mortality worldwide. It has been proven that the N6-methyladenosine (m6A) alteration is an important regulator of human cancer, however, it is unclear how FTO affects gemcitabine resistance in pancreatic cancer.Methods: Gemcitabine resistant pancreatic cancer cells and tissues were used to evaluated the expression level of FTO. The biological functions of FTO to gemcitabine resistant cells were investigated through cell counting kit-8, colony formation assay, flow cytometry and inhibitory concentration 50. Immunoprecipitation/MassSpectrometry, methylated RNA immunoprecipitation sequencing, RNA sequencing and RNA immunoprecipitation assays, RNA stability, luciferase reporter, and RNA pull down assays were performed to explore the mechanism of FTO in gemcitabine resistant pancreatic cancer cells.Results: FTO was substantially expressed in cells and tissues that were resistant to gemcitabine. Functionally, FTO enhanced gemcitabine resistance of pancreatic cancer in vitro. Depletion of FTO inhibited tumor growth of gemcitabine resistance cells in vivo. By immunoprecipitation/massSpectrometry we found FTO protein can be bound to USP7 and deubiquitinated by USP7 and lead to the upregulation of FTO. Mechanistically, FTO knockdown substantially reduced the expression level of NEDD4 in an m6A dependent manner. FTO enhanced the mRNA stability of NEDD4 through targeting its exonic regions. RNA pull down and RNA immunoprecipitation verified YTHDF2 was the reader of NEDD4. NEDD4 promoted the proliferation and chemoresistance of gemcitabine resistance cells. FTO knockdown markedly reduced RRM1 expression level in NEDD4 dependent manner, thus influence the chemosensitivity to gemcitabine in pancreatic cancer cells. Conclusion: We found FTO regulated gemcitabine resistance in pancreatic cancer by demethylated NEDD4 RNA in m6a-dependent manner which then influenced the RRM1 expression level. Meanwhile, we identified FTO protein level can be upregulated by USP7.
Heart Failure Classification based on Resting Ejection Fraction does not Display a Unique Exercise Response Pattern
Authors: Wernhart Simon , Papathanasiou Maria , Hedderich Juergen , Rassaf Tienush , Luedike Peter 
Published: August 2022

Abstract
Background:Heart failure with preserved (HFpEF), mildly reduced (HFmrEF) and reduced (HFrEF) ejection fraction (EF) remains a controversial categorization. Since variables of cardiopulmonary exercise testing (CPET) have been associated with cardiopulmonary morbidity, they may provide additional benefit to better classify heart failure patients. We aimed to analyze whether predictive CPET variables differ between all heart failure categories. We analyzed predictive CPET variables of HFpEF (n=123), HFmrEF (n=31), and HFrEF (n=153) patients reporting to our clinic between 01.04.2021 and 31.03.2022. Laboratory markers and transthoracic echocardiography were performed within 48 hours of CPET. The association between heart failure category and peak oxygen consumption (VO2peak) was used as a primary outcome, while the association between HF category and oxygen uptake efficiency slope (OUES), increase of O2 pulse during exercise, VE/VCO2, exercise oscillatory ventilation (EOV), rise of endtidal CO2 (PETCO2) >3mmHg during exercise, and the oxygen equivalent at the first ventilatory threshold (EqO2 at VT1) were analyzed as secondary outcomes.Results:VO2peak displayed a consistent decline with EF (19.8±6.2ml/kg/min vs. 17.5± 7.9ml/kg/min vs. 13.7± 4.0ml/kg/min, p<.001). Increase of O2 pulse (7.7±3.5ml vs. 5.5±3.0ml, p<.001), EqO2 at VT1 (25.7±7.2ml vs. 27.3±5.8ml, p=.001) and VE/VCO2 (34.9±8.9 vs. 39.1±10.7, p=0.001) only differed between HFpEF and HFrEF, while OUES showed differences between HFpEF and HFrEF (1.8±0.6 vs 1.4±0.5, p<.001) as well as HFmrEF and HFrEF (1.9±0.9 vs. 1.4±0.5, p=0.004). EOV (p=0.081) and rise of PETCO2>3mmHg (p=0.399) showed no difference between groups. BB intake resulted in lower VO2peak in HFpEF and HFmrEF, but higher values in HFrEF (each p<.001).Conclusions:Major predictive CPET variables differed between HFpEF and HFrEF, but distinction to HFmrEF was not consistent across variables. Thus, the current EF-based categorization does not appropriately reflect exercise limitations. CPET variables could contribute to better characterize HF.