bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low expression of miR-27b in serum exosomes of non-small cell lung cancer facilitates its progression by affecting EGFR
Authors: Cao Xiying , Zhong Weixiang , Guo Shaoming , Zhang Zuxiong , Xie Chunfa 
Published: April 2022

Abstract
Non-small cell lung cancer (NSCLC) is a malignant tumor. Serum exosomal miR-27b is related to tumor diagnosis. We explored the roles of serum exosomal miR-27b in NSCLC. NSCLC patients were assigned to NSCLC-early/terminal groups, with healthy subjects as controls. miR-27b expression was assessed using reverse transcription-quantitative polymerase chain reaction, and its diagnostic efficiency was analyzed using the receiver operating characteristic curve. The correlation between serum exosomal miR-27b expression and tumor markers carcinoembryonic antigen 125 (CA125), carcinoembryonic antigen (CEA), and cytokeratin 19-soluble fragment (CYFRA21-1) was analyzed using the Pearson analysis. The downstream target genes were predicted. Epidermal growth factor receptor (EGFR) level was assessed using enzyme-linked immunosorbent assay. Correlations of miR-27b expression with serum EGFR level and CA125, CEA, and CYFRA21-1 levels were analyzed using the Pearson analysis. Serum exosomal miR-27b was diminished in NSCLC and was further decreased in the NSCLS-terminal group. The sensitivity of miR-27b < 0.8150 for NSCLC diagnosis was 76.64%, and the specificity was 83.33%. Serum exosomal miR-27b was negatively correlated with CA125, CEA, and CYFRA21-1. miR-27b targeted EGFR. Serum EGFR was raised in NSCLC and was further elevated in the NSCLS-terminal group. miR-27b expression was negatively correlated with EGFR level. EGFR level was positively correlated with CA125, CEA, and CYFRA21-1 levels. Collectively, low expression of miR-27b assisted NSCLC diagnosis, and miR-27b exerted effects on NSCLC through EGFR.
Application of cyclohexene oxide modified chitosan for paper preservation
Authors: Wang Xuemei , Qi Yingping , Shen Yongfeng , Li Hua 
Published: April 2022

Abstract
A new chitosan derivative (CS-CHO) was successfully synthesized based on chitosan (CS) and cyclohexene oxide (CHO). It proved that CHO was successfully grafted onto the amino group of CS by N-alkylation reaction through the characterization of FTIR, XRD and DSC-TGA. The mechanical properties (tensile strength, folding endurance, tearing strength), optical properties (whiteness, glossiness) of the CS-CHO coated paper sample were tested. The results showed that the mechanical properties of the paper treated with 10 % CS-CHO increased significantly without changing the appearance of the paper. The paper permanence (tensile strength, folding endurance, tearing strength and pH) of the treated paper samples tested by dry-heat aging test. The results showed that the permanence of the treated paper samples was significantly improved compared with the blank aged paper samples, which indicated that CS-CHO had the function of deacidification while reinforcing the paper samples, providing the possibility for deacidification and reinforcement in one-step method and playing a positive role in the paper preservation.
Farmers’ perception, awareness, and constraints of organic rice farming in Indonesia
Authors: Sujianto  , Gunawan Endro , Saptana  , Syahyuti  , Darwis Valeriana , Ashari  , Syukur Mat , Ariningsih Ening , Saliem Handewi P. , Mardianto Sudi , Marhendro  
Published: April 2022

AbstractThe green revolution and climate change have become a promising Indonesian rice production strategy to reach self-sufficiency through the application of improved agricultural technology such as organic rice farming (ORF). ORF is an eco-friendly agricultural practice that increases production, income, and sustainable agriculture. This study assessed farmers’ perception, motivation, constraints, awareness, and belief in adopting ORF. The study used a multi-stage sampling procedure. The primary data were collected from 203 households in West Java Province using a structured questionnaire. Weighted average index (WAI) was used to assess the farmers’ perception, motivation, awareness, and belief regarding the adoption of ORF. The results reveal a significantly different perception between ORF and conventional rice farming (CRF) farmers on production, quality, health and safety, market price, environmental concern, and certification aspects. ORF farmers had a more positive perception than conventional farmers. The results of the WAI reveal that CRF had a lower yield (0.63), risk-averse (0.70), and no cash compensation (0.62), whereas ORF had a higher price (0.82) and organic farming lifestyle (0.83). The ORF farmers also still have a strong positive belief in organic farming for the future, even though they lack organic fertilizer resources and certification. The strategies for adopting ORF are infrastructure improvement and community empowerment, compensation and incentive strategy, more intensive socialization, provision of assistance and training related to ORF, marketing facilitation, and subsidies on the prices and certification of organic rice.
Multimodality in Hong Kong government posters from the 1950s–1980s: an appraisal analysis and the discursive construction of legitimation
Authors: Wong May L-Y 
Published: April 2022

Abstract
This paper uses van Leeuwen’s (2008. Discourse and practice: New tools from critical discourse analysis. Oxford: Oxford University Press) Authority Legitimation framework to examine government posters published in the 1950s–1980s in Hong Kong, which serve as a means of shaping public opinion and legitimate social action. Martin and White’s (2005. The language of evaluation: Appraisal in english. London: Palgrave Macmillan) Appraisal framework is also applied to provide the study with relevant analytical tools by which to construct evaluatively coherent authorial reading positions propagated by the government in the posters as well as aligning viewers with these desired positions. The government posters being studied are concerned with various aspects of social practices in the domain of public health communication. This paper argues that the representations of these social practices are realized as texts – both visual and verbal – in the posters, as part of a broader recontextualization process where legitimate ways of doing things as stipulated in the government guidelines are recontextualized in these posters and conveyed to members of the public. The aim is two-fold: (1) to provide a systematic analysis of how visual and verbal resources construe evaluation in the government posters and the consequent legitimation discourse as viewers are being persuaded to align with legitimate social practices; (2) to highlight various forms of legitimation, namely, role model authority legitimation, impersonal authority legitimation, and conformity authority legitimation, that are realized in these posters through visual-verbal articulation.
Valery Podoroga’s Theory of Mimesis: the Sensory Aspects of Text Perception
Authors: Juodeika Rytis 
Published: April 2022

The paper aims to analyse and understand tensions and meanings in the notion of mimesis in the perspective of philosophical anthropology. Classical mimesis theories, which stretch from classical antiquity to modern works by E. Auerbach or P. Ricoeur, are often associated with poetics, narratology or other literature theory studies. V. Podoroga talks about anthropological and phenomenological mimesis, not only about ‘external’, Aristotelian version, but also about internal mimesis. He focuses on the experience of the body as the basis of mimesis. The author explains how mimesis in Podoroga’s version acquires new meanings and demonstrates how Podoroga’s matrixes of anthropograms complement, discuss and transgress hermeneutical models of Ricoeur.The author claims that the method of Podoroga brings us to some kind of a unique ‘system’, that could be compared to the ideas of ‘the death of the author’ (R. Barthes) or ‘the open work’ (U. Eco). Podoroga shows us an alternative, non-semiotic and mimetic approach in contemporary thought, that has not been widely discussed yet in both Russian and English sources.
An Arendtian Reading of Antigone: Tyrrany Emerging from Righteousness
Authors: Basturk Efe 
Published: April 2022

The aim of this article is to investigate the tyrannical similarity between Antigone and Creon through Hannah Arendt’s political philosophy. As Arendt claimed, tyranny firstly signals the end of the political through which men can share their natality. The very meaning of tyranny is the domination by absoluteness that ends deliberation among mortal beings. Antigone only focuses on the divine law, which is seen as absolute righteousness that precedes the law of the city, and so, she tends to ignore any other option on rightfulness. This article aims to show that not only Creon but also Antigone can be regarded as a tyrant, since Antigone tends to sublime her dedication to an infallible justice, causing her to deny any other claim on justice.
The influence of the physicochemical nature of the components of the V2O5/GaAs, MnO2/GaAs, V2O5/InP, MnO2/InP, TiO2/InP, and SnO2/InP heterostructures and the oxidation conditions on the surface morphology of the synthesised films
Authors: Ковалева Анастасия Сергеевна , Сладкопевцев Борис Владимирович , Самсонов Алексей Алексеевич , Алферова Светлана Ивановна , Ковалев Данила Геннадьевич , Титов Сергей Александрович , Пряхин Никита Дмитриевич , Миттова Ирина Яковлевна 
Published: April 2022

The formation of oxide functional films on the surface of semiconductors is a serious technological challenge, which is even more complicated in the nanometre thickness range. It is necessary to form films with specified values of thickness, resistivity, and a certain surface morphology for practical applications. Such films are used in micro- and optoelectronics, environmental monitoring, and alternative energy devices. The goal of this work is to establish the features of the surface morphology of thin films formed as a result of the thermal oxidation of the MnO2/GaAs, V2O5/GaAs, V2O5/InP, MnO2/InP, TiO2/InP, and SnO2/InP heterostructures depending on the physicochemical nature of the components and the oxidation conditions. The synthesis of thin films on the InP and GaAs surfaces was carried out by thermal oxidation under the influence of magnetron-deposited layers of chemostimulator-modifiers. The thickness of the formed films and their composition were determined by laser ellipsometry, X-ray phase analysis, and infra-red spectroscopy. The scanning tunnel and atomic force microscopy were used to determine the morphological characteristics of the films and their dependence on the type of semiconductor substrate, the nature of the chemostimulator-modifier, and the conditions of the thermal oxidation. The application to the GaАs and InP surfaces of the most effective chemostimulator-modifiers (V2O5 and MnO2) of thermal oxidation and higher temperatures of the oxidation process contributed to the formation of smoother and nanostructured films.
A Note on the Estimation of the Maximum Possible Earthquake Magnitude Based on Extreme Value Theory for the Groningen Gas Field
Authors: Zöller Gert 
Published: April 2022

ABSTRACT
Extreme value statistics is a popular and frequently used tool to model the occurrence of large earthquakes. The problem of poor statistics arising from rare events is addressed by taking advantage of the validity of general statistical properties in asymptotic regimes. In this note, I argue that the use of extreme value statistics for the purpose of practically modeling the tail of the frequency–magnitude distribution of earthquakes can produce biased and thus misleading results because it is unknown to what degree the tail of the true distribution is sampled by data. Using synthetic data allows to quantify this bias in detail. The implicit assumption that the true Mmax is close to the maximum observed magnitude Mmax,observed restricts the class of the potential models a priori to those with Mmax=Mmax,observed+ΔM with an increment ΔM≈0.5…1.2. This corresponds to the simple heuristic method suggested by Wheeler (2009) and labeled “Mmax equals Mobs plus an increment.” The incomplete consideration of the entire model family for the frequency–magnitude distribution neglects, however, the scenario of a large so far unobserved earthquake.
Effect of service quality PT. Cross Marga Sedaya on consumer satisfaction in use e-toll card on Cipali toll road
Authors: Budiastuti Endah , Agustin Nindiya 
Published: April 2022

This research is motivated by the finding when the toll gates on the Cipali toll road do not provide transaction service satisfaction and services that are not in accordance with customer expectations such as the availability of substations at the gate which in reality cannot meet the surge in customers, especially during working hours and on holidays. In addition, the availability of ramps is also not proportional to the number of vehicles exiting the Cipali toll gate. This shows that there are problems regarding transaction services which have implications for the low transaction speed of toll road customers. To test these variables, researchers used hypothesis testing using simple regression and quantitative methods using correlational techniques. The data analysis technique uses a simple regression technique. The results showed that the influence of PT.Lintas Marga Sedaya's service quality on consumer satisfaction in using the E-Toll Card on the Cipali toll road was in the very strong category. This is based on the value of rcount = 0.937 which is in the correlation interval 0.800–1,000 with a very strong category. In order to determine the significance level at = 0.05 (5%) the value of tcount = 26,216 and ttable = 1.66105. Thus, tcount > ttable, which means that there is a significant effect between variable X on variable Y, where the contribution of service quality to satisfaction is large. consumers by 87.9% and the remaining 12.1% is influenced by other factors not examined in this study.
A IMPORTÂNCIA DAS OLIMPÍADAS DE MATEMÁTICA PARA O ENSINO MÉDIO NO CONTEXTO DA COMPREENSÃO DE CONTEÚDOS
Authors: Batista da Silva Vanúbya , Martins Glêndara Aparecida de Sousa , Teixeira Paulo Cléber M. , Silva Warley Gramacho da 
Published: April 2022

A Matemática é vista por muitos como uma disciplina de difícil compreensão, mas quando são aplicados projetos no ensino desta haverá uma maior interação dos discentes em sala de aula fazendo com que o processo de ensino-aprendizagem seja mais significativo. Deste modo, buscamos mostrar no presente trabalho que projetos de extensão contribuem de forma significativa para o ensino da Matemática, um exemplo que temos são as olimpíadas de Matemática que agregam importância para a aprendizagem dos conceitos matemáticos, uma vez que são feitos para estimular os estudos na área, além de buscar identificar talentos. Dessa forma, temos como foco principal a Olimpíada Brasileira de Matemática das Escolas Públicas (OBMEP) e seus reflexos para a educação brasileira, assim buscamos mostrar por meio de uma pesquisa bibliográfica sua relevância para os alunos que participam e são classificados e a importância para o ensino médio no contexto da compreensão de conteúdos.
Palavras-chave: Matemática, Olimpíadas, OBMEP.
Posterior laminectomy and lateral mass screw fixation for the treatment of severe cervical spondylotic myelopathy
Authors: Zheng Qixin , Chuang Li , Wu Bin , Wu Yongchao , Pan Haitao 
Published: April 2022

Abstract
Background:Severe and complex cervical spondylotic myelopathy(CSM) requires surgical treatment, usually laminoplasty or laminectomy with lateral mass screw internal fixation. However, the operative effects of these surgical approaches are unclear.Therefore, we aimed to evaluate the clinical effects of posterior cervical laminectomy and lateral mass screw internal fixation in patients with severe and complex CSM.Methods:We retrospectively analysed 60 patients with severe and complex CSM who underwent posterior cervical laminectomy and lateral mass screw internal fixation between May 2013 and June 2020. C-spine radiographs, computed tomography scans, and magnetic resonance images were used to detect curvature and fusion of the cervical spine, restenosis, and loose/broken internal fixation screws. Clinical efficacy was evaluated using Japanese Orthopaedic Association (JOA)scores, the neck disability index (NDI), Odom’s classification, and the visual analogue scale (VAS) for pain.Results: At the last follow-up, there was no restenosis or loosened/broken internal fixations. The anterior curvature angle of lordosis (n=46) at the last follow-up was not different from that at baseline (P>0.05). The cervical kyphosis angle (n=14) at the last follow-up was improved compared with that at baseline (P<0.05), as were the JOA, NDI, and VAS scores (all P<0.05). Odom’s classifications at the last follow-up were excellent, good, and fair in 45, 12, and 3patients, respectively.Conclusions: Posterior cervical laminectomy and lateral mass screw internal fixation achieved satisfactory clinical results in severe and complex CSM cases:the cervical spine was stabilised, achieving spinal decompression while preventing excessive backward drift of the cervical spinal cord.
The circulating miRNA-34a, miRNA -143 and miRNA -212 are promising biomarkers in ovarian cancer
Authors: Kheirandish Shahnaz , Zarezade Zeynab , Yavari Mahdie , Sheikhha Mohammad Hasan , Kalantar Seyyed Mahdi , Sahami-Fard Mohammad Hossein , Hasani Shahrzad Sheikh , Ghasemi Nasrin , Jahantigh Hamid Reza 
Published: April 2022

Abstract
Objective: Ovarian cancer is one of the most common gynaecological malignancies among females worldwide. Early diagnostic of ovarian cancer is challenging, and miRNAs could serve as a potential biomarker for early detection of ovarian cancer regarding easy to detect. The present study investigated the expression profile of miRNA-34a, miRNA-143, miRNA-212, Sox4, BCL-2, and E2f5 in the serum of participants to find new biomarkers for early diagnosis of ovarian cancer. Materials and Methods: Five milliliters of whole blood were collected from each patient (n=30) and control (n=30), and total RNA was extracted using Ambion™ TRIzol™ Reagent. Real-time PCR methods evaluated the expression of targeted miRNAs and their targeted genes. Result: The Disease status of all ovarian cancer patients were classified as FIGO stage III (21) and (IV 9) according to imaging studies and surgical pathological findings. Our results showed that expression levels of miRNA-34a (p<0.0001), miRNA-143 (p=0.028), and miRNA-212 (p<0.0001) were significantly decreased in patients with ovarian cancer compared to controls and expression levels of Sox4(p<0.0001), BCL-2(p<0.0001) and E2f5(p<0.0001) were significantly increased in patients with ovarian cancer compared to controls. In addition, Receiver Operating Characteristic (ROC) curve revealed that the expression profile of miRNA-34a (AUC= 0.82; P <0.0001), miRNA-143 (AUC= 0.66; P = 0.026) and miRNA-212 (AUC= 0.78; P = 0.0001) could be used as potential biomarker for discriminating patients with ovarian cancer. Conclusion: In conclusion, our data showed that the expression profile of miRNA-34a, miRNA-143, and miRNA-212 could act as a potential biomarker for diagnosing ovarian cancer patients.
Tracing nuanced dietary patterns on the Great Hungarian Plain: Carbon and nitrogen isotopic analysis of Bronze and Iron Age populations
Authors: McCall Ashley , Gamarra Beatriz , Carlson Kellie Sara Duffett , Bernert Zsolt , Cséki Andrea , Csengeri Piroska , Domboróczki László , Endrődi Anna , Hellebrandt Magdolna , Horváth Antónia , Király Ágnes , Kiss Krisztián , Koós Judit , Kovács Péter , Köhler Kitti , Szolnoki László , Zoffmann Zsuzsanna K. , Sirak Kendra , Szeniczey Tamás , Dani János , Hajdu Tamás , Pinhasi Ron 
Published: April 2022

Abstract
The Great Hungarian Plain (GHP) served as a geographic funnel for population mobility throughout prehistory. Genomic and isotopic research demonstrates non-linear genetic turnover and technological shifts between the Copper and Iron Ages of the GHP, which influenced the dietary strategies of numerous cultures that intermixed and overlapped through time. Given the complexities of these prehistoric cultural and demographic processes, this study aims to improve our understanding of diachronic and culture-specific dietary signatures. Here we report on stable carbon and nitrogen isotope values from 75 individuals from twenty sites in the GHP dating to a ~ 3000-year time span between the Early Bronze and Early Iron Ages. The samples broadly indicate a terrestrial C3 diet with nuanced differences amongst cultures, suggesting exogenous influences that manifested in subsistence strategies. Compared to the Iron Age, the Bronze Age samples have slightly elevated δ15N values implying higher reliance on protein. Interestingly, carbon values typical of C4 vegetation indicate the consumption of millet, or a grain with comparable δ13C values during the Middle Bronze Age. Overall, our results suggest a gradual transition in dietary patterns from the Early Bronze to Early Iron Age, demonstrating a relationship between subsistence and time periods, congruent with the archaeological record.
A Data-driven Fairness-based Time of Use Tariff Design
Authors: Li Victor , Lam Jacqueline , Guo Peiyang , Newbery David , Chan Kelvin 
Published: April 2022

Abstract
Time of use (TOU) tariffs aim to shape demand, by reducing peak demand and otherwise changing the load shape, which is of heightened relevance as energy supplies come under pressure and transition from fossil fuels to more volatile renewable sources. However, TOU tariffs may carry distributional consequences, such as higher bills for all users/low-income users. With the increasing prospect of steep increases in energy bills in Europe, a fairness-based approach TOU tariff design deserves proper attention by the world’s regulatory regimes. A flexible, fairness-based TOU tariff design is proposed, utilizing a 4-step data-driven approach to segment households by income and price responsiveness, followed by potential tariff filtering to simultaneously lower total costs, distribute cost savings progressively and maintain constant utility profitability. The new tariff design approach is demonstrated using the 2009-10 Irish Smart Metering Trial, and produces promising results.
Invasive aspergillosis in lung transplant recipients: a retrospective clinical analysis in a single center
Authors: Zhao Li , Chen Wenhui , Guo Lijuan , Liang Chaoyang , Wang Chen 
Published: April 2022

Abstract
Invasive aspergillosis (IA) infection is common and remains a major cause of morbidity and mortality in lung transplant recipients (LTRs).In this observational cross-sectional study, we gathered clinical data of 157 adult LTRs from March 2017 to December 2018 in a lung transplant center in China. All recipients were followed until the end of March 2019. Forty-three of the 157 LTRs (27.4%) developed IA infection. The most common pathogens were Aspergillus flavus (n=16/37 strains, 43.2%), followed by Aspergillus fumigatus (n=11/37 strains, 29.7%) and Aspergillus niger (n=5/37 strains, 13.5%). Intravenous echinocandins and inhaled amphotericin B were universally used for antifungal prophylaxis. The vast majority of infected LTRs (83.7%, 36/43) were treated with voriconazole monotherapy, and the rest (16.3%) were voriconazole-based combination therapy. The all-cause mortality 1 month and 6 months postoperatively was 4.7% and 18.6% respectively, and 34.9% had died at the conclusion of this study. The mortality rate of patients with early-onset IA (within 3 months) reached 40.0%, which seemed to be higher than that of patients with late-onset IA (more than 3 months, 12.5%). The incidence of IA in LTRs is high. The most common form of infection was TBA, with Aspergillus flavus as the main pathogenic fungus. Due to poor prognosis, it is important to select appropriate antifungal prophylaxis strategy and initiate antifungal therapy as early as possible upon confirmation of the diagnosis of IA infection.