bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transesophageal Doppler corrected flow time versus plethysmography variability index for goal-directed fluid management in cirrhotic patients during liver resection: a randomized controlled trial
Authors: Abdelhafez Hanaa S. , Yassen Khaled A. , El Sahn Fatima F. , Mostafa Ashraf M. 
Published: December 2022

Abstract
Background
Central venous pressure (CVP) readings are affected by several factors. The need to test the technology of noninvasive or minimal invasive monitoring during liver surgery to guide fluids intake is the focus of this trial. Adult hepatic patients undergoing elective open liver resection were randomized into transesophageal Doppler (TED, n = 20) or plethysmography variability index (PVI, n = 20). PVI blinded to anesthetist in TED group (gp) and vice versa. During dissection, crystalloids were restricted to keep corrected flow time (FTc) parameter of TED < 330 msec or PVI > 14%, otherwise infused at 6 ml/kg/h. Following resection, colloids infused if FTc < 330 msec or PVI > 14% despite crystalloids infusion. Primary aim is to compare TED-corrected flow time (FTc, msec) parameter to PVI (%) for guiding intravenous fluids during liver resection. Secondary to study their correlations and each parameter effect on blood loss and consumption, morbidity and intensive care unit (ICU) stay.

Results
It is presented as median [IQ]. Volumes of crystalloids and colloids guided by FTc and PVI were not different (p = 0.3, p = 0.1, respectively) despite negligible correlations. Normovolemic existed during dissection despite 2 h of fluids restriction. FTc was 327 (320–341) msec, PVI was 11.50 (11.00–14.00) %, and CVP in TED gp 11.00 (10.00–12.00) vs. 9.00 (9.00–11.50) mmHg in PVI gp, p = 0.2. Blood loss was 1500 (475–2000) ml in TED vs. 950 (675–1925) in PVI, p = 0.5. Patients’ % in need for blood transfusion and volumes in TED vs. PVI gps were similar: red blood cells: 30%, 350 (350–350) vs. 40%, 525 (350–700) ml, and p = 0.2. Plasma is 20%, 200 (200–300) vs. 40%, and 400 (200–400) ml, p = 0.3. There was no difference in nausea, vomiting, or ICU stay, (p > 0.05).

Conclusions
Volume of fluids guided by PVI was not different from that by TED, despite lack of correlation. Transfusion-free dissection was possible for a significant number of patients with normovolemia.

Trial registration
PACTR201808140151322 (www.pactr.org)
The anti-Alzheimer compounds from tempeh oil in LPS-induced neuronal Schwann cells
Authors: Limanjaya Eileen C. , Subali Dionysius , Yanti Yanti 
Published: December 2022

AbstractTempeh is a traditional fermented Indonesian food from white soybean. Tempe has better nutritional value than non-fermented white soybean. The aim of this study was to extract tempeh oil and analyze the inhibitory potency of Alzheimer-related gene expression in LPS-induced neuronal Schwann cells. Tempeh oil was extracted with Bligh Dyer method and was analyzed with PUFA identification, anticholinesterase activity, antioxidant activity, and quantitative PCR. Tempeh oil had a total yield of 7.14%, and PUFA identification found 8.37% omega-3. The anti-acetylcholinesterase activity showed that tempeh oil 25 µg/mL had the highest activity and 500 µg/mL in anti-butyrylcholinesterase activity. The quantitative PCR showed that tempeh oil had downregulated the gene expression of PSEN1, Gsk3b, cdk5, and TNF. From this study, tempeh oil may have the potential to lower the risk of Alzheimer’s disease by regulating certain gene traits.
Plastic recycling plant as a point source of microplastics to sediment and macroinvertebrates in a remote stream
Authors: Kallenbach Emilie M. F. , Eriksen Tor Erik , Hurley Rachel R. , Jacobsen Dean , Singdahl-Larsen Cecilie , Friberg Nikolai 
Published: December 2022

AbstractMicroplastic is now ubiquitous in freshwater, sediment and biota, globally. This is as a consequence of inputs from, for example, waste mismanagement, effluents from wastewater treatment plants and surface runoff from agricultural areas. In this study, we investigated point source pollution of plastic to an upland stream, originating from a recycling plant that recycles polyethylene film in a remote area of Norway. Sediment (~2 kg) and macroinvertebrates (549 individuals in total) were sampled at one site upstream and two sites downstream of the recycling plant to study microplastic deposition and food web uptake. In total, 340 microplastic films were identified through a combination of visual and µFTIR analysis in the sediment samples. This corresponded to a concentration of 0.23 (± 0.057) items per g sediment upstream of the plastic recycling plant and 0.45 (± 0.017) and 0.58 (± 0.34) items per g downstream. The dominant plastic polymer was polyethylene, which increased significantly downstream of the plastic recycling plant. This indicates the role of the plastic recycling plant as a point source for microplastic in this catchment. Among the three sites investigated, a fairly constant concentration of polypropylene was found, indicating a diffuse source of polypropylene films across the catchment possibly relating to low-intensity agricultural land-use. Low levels of polyethylene were also observed upstream, which may be linked to either local or longer-distance atmospheric transport. Despite the considerable presence of microplastic in sediments, concentrations in macroinvertebrates were extremely low with only a single microplastic particle identified in the total of 549 macroinvertebrates—belonging to three different feeding groups—investigated. Our study suggests that: 1) microplastic pollution can be transferred to remote areas as unintended losses from recycling facilities, 2) remote areas with limited land-use pressure still have detectable levels of microplastic and 3) microplastic is only taken up by stream macroinvertebrates to a limited degree despite relatively high sediment concentrations, and thus there are no strong indications for ecological risks posed by microplastic to this ecological group at this location.
Mepitel Film for the Prevention of Acute Radiation Dermatitis in Breast Cancer: A Randomized Multicenter Open-Label Phase III Trial
Authors: Behroozian Tara , Milton Lauren , Karam Irene , Zhang Liying , Ding Keyue , Lou Julia , Gallant François , Rakovitch Eileen , Tran William , Soliman Hany , Leung Eric , Vesprini Danny , Szumacher Ewa , Chen Hanbo , Donovan Elysia , Lam Jacqueline , Spadafora Silvana , Wronski Matt , Lavoie Chris , Walde Natalie , Lam Emily , Wong Gina , McKenzie Erin , Ariello Krista , Kennedy Samantha , Shariati Saba , Carothers Katherine , Gonzales Glen , Kagan Yulya , Chow Edward 
Published: December 2022

PURPOSE Radiation dermatitis (RD) is common in patients undergoing breast radiotherapy. Mepitel film (MF) can reduce RD, but the results from two randomized controlled trials are conflicting. We aimed to conduct a confirmatory randomized controlled trial in patients at risk of RD. METHODS Patients were randomly assigned to receive MF or standard care (2:1 ratio). Patients with large breasts after lumpectomy (bra size ≥ 36 inches or cup size ≥ C) or after mastectomy were eligible. Stratification factors included surgery type, dose fractionation, and administration of boost/bolus. The primary end point was grade (G) 2 or 3 RD using the Common Terminology Criteria for Adverse Events v5.0. Secondary end points included patient- and clinician-reported outcomes. RESULTS Between January 2020 and May 2022, 376 patients were included in the modified intention-to-treat analysis. The incidence of G2 or 3 RD was significantly lower in MF patients compared with standard care (n = 39/251, 15.5%; 95% CI, 11.3 to 20.6% v n = 57/125, 45.6%; 95% CI, 36.7 to 54.8% respectively, odds ratio (OR): 0.20, P < .0001). Benefits of MF remained significant in patients who developed G 3 RD (n = 7, 2.8%; 95% CI, 1.1 to 5.7% v n = 17, 13.6%; 95% CI, 8.1 to 20.9%, OR: 0.19) and moist desquamation (n = 20, 8.0%; 95% CI, 4.9 to 12.0% v n = 24, 19.2%; 95% CI, 12.7 to 27.1%, OR: 0.36). When evaluating the combined patient and health care provider score using Radiation-Induced Skin Reaction Assessment Scale, the MF arm had significantly lower scores ( P < .0001). Individual items on the Radiation-Induced Skin Reaction Assessment Scale also favored the MF for both patient- and clinician-reported outcomes. Blistering/peeling, erythema, pigmentation, and edema were significantly reduced in the MF arm. Three patients removed the film prematurely because of rash (n = 2) and excessive pruritus (n = 1). CONCLUSION MF significantly reduces RD in patients undergoing breast radiotherapy.
New Horizons: Artificial Intelligence Tools for Managing Osteoporosis
Authors: Dimai Hans Peter 
Published: December 2022

AbstractOsteoporosis is a disease characterized by low bone mass and microarchitectural deterioration leading to increased bone fragility and fracture risk. Typically, osteoporotic fractures occur at the spine, hip, distal forearm, and proximal humerus, but other skeletal sites may be affected as well. One of the major challenges in the management of osteoporosis lies in the fact that although the operational diagnosis is based on bone mineral density (BMD) as measured by dual x-ray absorptiometry, the majority of fractures occur at nonosteoporotic BMD values. Furthermore, osteoporosis often remains undiagnosed regardless of the low severity of the underlying trauma. Also, there is only weak consensus among the major guidelines worldwide, when to treat, whom to treat, and which drug to use. Against this background, increasing efforts have been undertaken in the past few years by artificial intelligence (AI) developers to support and improve the management of this disease. The performance of many of these newly developed AI algorithms have been shown to be at least comparable to that of physician experts, or even superior. However, even if study results appear promising at a first glance, they should always be interpreted with caution. Use of inadequate reference standards or selection of variables that are of little or no value in clinical practice are limitations not infrequently found. Consequently, there is a clear need for high-quality clinical research in this field of AI. This could, eg, be achieved by establishing an internationally consented “best practice framework” that considers all relevant stakeholders.
Acacia mangium: A promising plant for isolating anti-hepatitis C virus agents
Authors: Wahyuni Tutik Sri , Sukma Nida S. , Permanasari Adita A. , Aoki-Utsubo Chie , Widyawaruyanti Aty , Hafid Achmad Fuad 
Published: December 2022

Background: Medicinal plants are potential resources for isolating drug candidates. Various plants have been reported to possess pharmacological effects including anti-hepatitis C activities. The current study examined the anti-hepatitis C virus (HCV) activities of Acacia mangium extracts in solvents with various polarities and further evaluated the mechanism of action of the extracts using Western blotting and combination treatment models. Methods: The leaves of A. mangium were extracted in two phases, first in ethanol and then in solvents with different polarities (n-hexane, dichloromethane, and methanol). HCV-infected Huh7it-1 cells were treated with the extracts at concentrations of 0.01, 0.1, 1, 10, 50, and 100 µg/mL. Results: The results revealed the strong anti-HCV activities of the extracts. The 50% inhibition concentrations (IC50s) of the ethanol, n-hexane, dichloromethane and methanol extracts were of 4.6 ± 0.3, 2.9 ± 0.2, 0.2 ± 0.3, and 2.8 ± 0.2 μg/mL, respectively, and no cytotoxic effect was detected. These extracts displayed stronger effects than the positive control ribavirin. The mode of action of the ethanol extract was evaluated at 30 µg/mL, revealing that the inhibitory effect was stronger on the post-entry step than on the entry step. Western blotting revealed that the extracts decreased NS3 protein expression, indicating that virus replication was suppressed. Further evaluation illustrated that combined treatment with the ethanol extract enhanced the anti-viral activity of simeprevir. Conclusions: These results indicated that A. mangium leaves could represent sources of anti-HCV agents.
Modelling time-varying volatility using GARCH models: evidence from the Indian stock market
Authors: Ali Farman , Suri Pradeep , Kaur Tarunpreet , Bisht Deepa 
Published: December 2022

Background: In this study, we examined the volatility of the Indian stock market from 2008 to 2021. Owing to the financial crisis, volatility forecasting of the Indian stock market has become crucial for economic and financial analysts. An empirical study of the returns of the NSE indices revealed an autoregressive conditional heteroskedastic trend in the Indian stock market. Methods: Using GARCH 1, 1 (generalized autoregressive conditional heteroskedasticity) and FIGARCH (fractionally integrated GARCH), we examine investor behaviour and the persistence of long-term volatility. Results: The empirical findings of the estimated models suggest that shocks persist for a long time in NSE returns. Furthermore, bad news has a greater impact on stock volatility than good news. The return on assets is stable but highly volatile, even though the Indian economy has experienced the global crash to some extent. Conclusions: Models of volatility derived from the GARCH equation provide accurate forecasts and are useful for portfolio allocation, performance measurement, and option valuation.
Molecular docking, ADMET profiling of gallic acid and its derivatives (N-alkyl gallamide) as an anti-breast cancer agent
Authors: Arsianti Ade , Nur Azizah Norma , Erlina Linda 
Published: December 2022

Background In 2020, breast cancer has become the most common cancer in the world and in Indonesia. Searching for anticancer drugs using computational methods is considered more effective and selective than other methods. Gallic acid and its derivatives (esters and amides) are compounds that have biological activities such as anticancer effects. The purpose of this study was to analyse the molecular modelling and ADMET (Adsorption, Distribution, Metabolism, Excretion and Toxicity) profile of gallic acid derivative compounds (N-alkyl gallamides) as anticancer agents. Methods Target proteins were selected by analysis of protein-protein and drug-protein interactions. Molecular modelling was done by molecular docking. Predictive analysis of the ADMET profile of gallic acid and its derivatives (N-alkyl gallamide) was conducted using Marvin Sketch, Swissadme, protox II, and pkCSM pharmacokinetics. The selected target proteins were JUN, AKT1, CASP3, and CASP7. Results Compounds N-octyl gallamide, N-ters-butyl gallamide, and N-isoamil gallamide were the three best gallic acid derivatives based on molecular modelling analysis of target proteins associated with breast cancer. The ADMET profile of the N-alkyl gallamide compound is predictable and shows a good profile as a candidate for anticancer drugs. Conclusion N-octyl gallamide, N-ters-butyl gallamide, and N-isoamil gallamide have potential as anti-breast cancer agents.
Profile: Maternal and Child Health Surveillance System in peri-urban areas of Karachi, Pakistan
Authors: Muhammad Zeb Muhammad Ilyas , Shahid Shahira , Naeem Komal , Fatima Urooj , Kazi Abdul Momin , Jehan Fyezah , Shafiq Yasir , Mehmood Usma , Ali Rashid , Ali Murtaza , Ahmed Imran , Zaidi Anita K.M. , Nisar Muhammad Imran 
Published: December 2022

A Maternal and Child Health Surveillance System (MCHSS) was set up by the department of pediatrics and child health, Aga Khan University, Pakistan in peri-urban areas of Karachi to provide a platform for various research projects. It was established in five low-socioeconomic communities in a stepwise manner between 2003 and 2014. The total area currently under surveillance is 18.6 km2 covering a population of 302,944. We maintain a record of all births, deaths, pregnancies, and migration events by two monthly household visits. Verbal autopsies for stillbirths, deaths of children under the age of five years and adult female deaths are also conducted. For over a decade, the MCHSS has been a platform for a variety of studies describing the burden of various infectious diseases like typhoid, pneumonia and diarrhea, evaluation of effectiveness of various treatment regimens for neonatal sepsis, assessment of the acceptance of hospitalized care, determination of the etiology of moderate to severe diarrhea, assessment of burden and etiology of neonatal sepsis and a multi-center cohort study measuring the burden of stillbirths, neonatal and maternal deaths. More recently we have also established a bio-repository of the well-characterized maternal and newborn cohort. Through a well-established MCHSS, we aim to provide concrete evidence base to guide policy makers to make informed decisions at local, national, and international levels.
Lexical outcomes of Karelian-Russian bilingualism in Tver Karelian
Authors: Tavi Susanna 
Published: December 2022

This study investigates the language contact between Tver Karelian and Russian, attempting to provide a comprehensive overview of the lexicon of bilingual code. The methodology includes a combination of statistical analyses and handling contact-induced change in terms of the Code-Copying Framework (=CCF). Nine interviews with nine people were conducted using the memory walk method. In code copying, correlations were found between different word classes and contact-relatedness. In code alternation, few differences were found between different speakers and one commonality was the use of complex numerals as Russian phrases without adapting them into the Tver Karelian code. The findings confirm that the copies are of a certain kindand appear in certain word classes. Code alternation sequences suggest that, according to the CCF, the discourse rather than the language is mixed. The findings within CCF have implications on minority language policies, as the findings support the use of bilingual terminology.
Kokkuvõte. Susanna Tavi: Karjala-vene kakskeelsuse mõju tverikarjala keele sõnavarale. Käesolevas uurimistöös uuritakse tverikarjala ja vene keele kontakte. See uuring püüab anda tervikliku ülevaate kakskeelse koodi sõnavarast. Metoodika sisaldab kombinatsiooni statistilistest analüüsidest ja kontaktidest põhjustatud muutuste käsitlemisest koodikopeerimise raamistiku (Code-Copying Framework = CCF) osas. Üheksa intervjuud üheksa inimesega viidi läbi mälukõnni meetodil. Leiti seoseid erinevate sõnaklasside ja kontaktidega seotuse vahel. Koodivahelduses leiti eri kõnelejate vahel vähe erinevusi ja üheks ühiseks jooneks oli keerukate arvsõnade kasutamine venekeelsete fraasidena, ilma neid tverikarjala koodi sobitamata. Leiud kinnitavad, et koopiad on teatud liiki ja esinevad teatud sõnaklassides. Koodi vaheldumise jadad viitavad sellele, et CCF-i kohaselt on segatud eelkõige diskursus, ja mitte keel. CCF-i leiud avaldavad mõju vähemuskeelte poliitikale, kuna leiud toetavad kakskeelse terminoloogia kasutamist.
study of pig dna analysis methods in cosmetics: a review
Authors: Sofiyani Ratu Amada , Hariyanti Hariyanti , Rahmi Hanifah 
Published: December 2022

Collagen is one of the components used for cosmetics. Functionally, collagen is derived from pig fat, which functions as a skin conditioning agent (Emollient), emulsion stabilizer (Emulsifier), and as ingredient to increase the viscosity of cosmetic preparations. The method that can detect pig content is the PCR method, which can confirm the presence of DNA content in pigs. In this study, an analysis of cosmetic products containing porcine DNA was carried out using the PCR method. This research was divided into two stages: the initial stage was DNA extraction, and the second stage was PCR analysis. This research is a study through literature study using the narrative review technique. This study aimed to collect information and examine the analysis method of identifying pig DNA contained in cosmetics to obtain the right and accurate way through a literature approach. From the literature study results, it can be concluded that the best extraction method for the isolation of porcine DNA in cosmetic preparations is the extraction method with the Boom Method, while the DNA analysis used to identify porcine DNA in cosmetics is RT-PCR (Real-time Polymerase Chain Reaction). Conventional PCR is because both methods have their respective advantages. The RT-PCR (Real-time Polymerase Chain Reaction) method can amplify and quantify the number of target DNA molecules. The Conventional PCR Method can form DNA bands based on the amplification value.
Machine learning-based analysis of multiple simultaneous disturbances applied on a transmission-reflection analysis based distributed sensor using a nanoparticle-doped fiber
Authors: Avellar Letícia , Frizera Anselmo , Rocha Helder , Silveira Mariana , Díaz Camilo , Blanc Wilfried , Marques Carlos , Leal-Junior Arnaldo 
Published: December 2022

Photonic technology combined with artificial intelligence plays a key role in the development of the latest smart system trends, integrating cutting-edge technology with machine learning models. This paper proposes a transmission-reflection analysis based system using dielectric nanoparticle-doped fiber combined with artificial intelligence to address one of the major problems in the distributed sensing approach: reducing the cost while maintaining high spatial resolution to close the gap between distributed sensors and the general public. Machine learning-based models are designed to classify the perturbed positions when the same force is used and force regression when different forces are applied on each position. The results show an accuracy of 99.43% in the position classification of multiple disturbances and an rms error of

1.53

N

in the force regression, which represents 5% of the force range. In addition, a smart environment using the current system is proposed, which presented 100% accuracy in identifying the positions of different persons in the environment. This smart environment enables remote home care of patients with high reliability, intelligent decision-making, and a predictive capability.