bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tolerability of duloxetine in elderly and in non-elderly adults: a protocol of a systematic review and individual participant data meta-analysis of randomized placebo-controlled trials
Authors: Roy Jean-Charles , Rousseau Chloé , Jutel Alexis , Naudet Florian , Robert Gabriel 
Published: April 2022

Abstract
Background
Duloxetine is an antidepressant that benefits from a wide range of approval in the elderly population, while its safety for use compared to non-elderly is not clearly assessed. This protocol outlines a systematic review and individual participant data meta-analysis comparing the tolerability of duloxetine between elderly and non-elderly.

Methods
Searches will be conducted in PubMed, ClinicalTrials.gov, Clinicaltrialsregister.eu, data sharing platforms, FDA drug approval packages, European public assessment reports and withdrawn applications from the EMA website. The review will be performed on studies available in electronic databases from their date of inception to the 31 March 2022. Only randomized controlled clinical trials, comparing duloxetine to placebo, will be included in this meta-analysis. The studies will be selected if they comprise both elderly and non-elderly adults, in conditions of use of duloxetine approved by the European Medical Agency (EMA) and the Food and Drug Administration (FDA). The primary outcome will be the rate ratio of serious adverse events under duloxetine compared to placebo, between participants at least 65 years old and non-elderly. Second, the number of any adverse events, clinical efficacy and quality of life will be compared between elderly and non-elderly under both interventions. The quality of evidence in the tolerability of duloxetine will be assessed using the GRADE system. A one or two-stage individual participant data random effect meta-analysis will be conducted depending on the availability of the data.

Discussion
This meta-analysis will investigate the tolerability safety of duloxetine in the elderly population across all conditions approved by European and American regulatory authorities. The results from this meta-analysis are intended to help prescribers to provide better care for the elderly population.

Systematic review registration
The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42019130488).
Effects of greenhouse gases and hypoxia on the population of aquatic species: a fractional mathematical model
Authors: Kumar Pushpendra , Govindaraj V. , Erturk Vedat Suat , Mohamed Mohamed S. 
Published: April 2022

AbstractStudy of ecosystems has always been an interesting topic in the view of real-world dynamics. In this paper, we propose a fractional-order nonlinear mathematical model to describe the prelude of deteriorating quality of water cause of greenhouse gases on the population of aquatic animals. In the proposed system, we recall that greenhouse gases raise the temperature of water, and because of this reason, the dissolved oxygen level goes down, and also the rate of circulation of disintegrated oxygen by the aquatic animals rises, which causes a decrement in the density of aquatic species. We use a generalized form of the Caputo fractional derivative to describe the dynamics of the proposed problem. We also investigate equilibrium points of the given fractional-order model and discuss the asymptotic stability of the equilibria of the proposed autonomous model. We recall some important results to prove the existence of a unique solution of the model. For finding the numerical solution of the established fractional-order system, we apply a generalized predictor–corrector technique in the sense of proposed derivative and also justify the stability of the method. To express the novelty of the simulated results, we perform a number of graphs at various fractional-order cases. The given study is fully novel and useful for understanding the proposed real-world phenomena.
Vertical program of screenings and check-ups in the Russian Federation: design, implementation and lessons learnt
Authors: Sheiman Igor , Shishkin Sergey , Sazhina Svetlana 
Published: April 2022

Abstract
Background
The Russian Federation has introduced a vertical large-scale program of ‘dispensarization’ (Program) that includes health check-ups and screenings for the entire adult population. It is expected to improve the results of medical interventions and ensure health gains at a relatively low cost. The major research question: Does the design and implementation of the program meet the expectations?

Methods
We analyze regulatory acts and the literature on the design and the outcomes of the Program. Physicians’ surveys and interviews are conducted to understand the capacity of primary care providers to meet the requirements of the Program, as well as the link between the early identification of new illnesses and their follow-up management, administration of the program, the barriers to its successful implementation.

Results
There is a substantial progress in the coverage of the population and increase in the number of identified illnesses. Some specific instruments of the Program implementation work well, others require more careful design and additional integrative and managerial activities. The capacity of primary care providers does not allow to provide high quality preventive services, as well as to ensure a continuum of preventive and curative work. The pattern of the Program administration facilitates its nation-wide implementation according to the unified rules, but makes it more difficult to account for the local conditions and limits the autonomy of professionals to choose specific population risk groups and a list of services. The interaction of providers in preventive activities is inadequate.

Conclusion
The expectations of the Program are too high due to the inconsistencies in its design and implementation. The major lesson learnt is that the program like this should meet the capacity of primary care and be designed as a complex of interrelated activities to identify illnesses and provide their follow-up management.
Factors influencing access to agro-processing training for small-scale crop farmers in Gauteng province of South Africa
Authors: Mthombeni Danisile Leonah , Antwi Michael Akwasi , Oduniyi Oluwaseun Samuel 
Published: April 2022

AbstractBackgroundThe agricultural economy has little room for emerging farmers and there is no strong support system available for the small-scale farmers venturing in agro-processing. In this study, “access to agro-processing training” refers to any processing training rendered to small-scale crop farmers to equip them when venturing in to agro-processing. Small-scale crop farmers trained with high knowledge in processing and skills are pre-disposed to adopting processing as a strategy of making their processed products penetrate the agro-processing market.MethodologyData were collected from 307 small-scale crop farmers and STATA version 15 was used to perform fractional regression analyses to determine factors influencing access to training from the five types of agro-processing training (marketing training, processing training, record-keeping training, financial management training and business-plan training).ResultsThe results revealed that 26% of the small-scale crop farmers had no access to agro-processing training and 74% of the small-scale crop farmers had access to training. Farming experience had significant influence on the access to agro-processing training for small-scale farmers to function efficiently in the agro-processing industry at 5% level of significance and their coefficient was positive.ConclusionSmall-scale crop farmers with less farming experience should be encouraged to participate in the agro-processing sector as their participation can result in improved income and food security at the household levels. Furthermore, new agro-processing training programmes should be encouraged as trained farmers are more likely to participate in the value addition activities of agro-processing.
Specific urban units identified in tuberculosis epidemic using a geographical detector in Guangzhou, China
Authors: Ren Hongyan , Lu Weili , Li Xueqiu , Shen Hongcheng 
Published: April 2022

Abstract
Background
A remarkable drop in tuberculosis (TB) incidence has been achieved in China, although in 2019 it was still considered the second most communicable disease. However, TB’s spatial features and risk factors in urban areas remain poorly understood. This study aims to identify the spatial differentiations and potential influencing factors of TB in highly urbanized regions on a fine scale.

Methods
This study included 18 socioeconomic and environmental variables in the four central districts of Guangzhou, China. TB case data obtained from the Guangzhou Institute of Tuberculosis Control and Prevention. Before using Pearson correlation and a geographical detector (GD) to identify potential influencing factors, we conducted a global spatial autocorrelation analysis to select an appropriate spatial scales.

Results
Owing to its strong spatial autocorrelation (Moran’s I = 0.33, Z = 4.71), the 2 km × 2 km grid was selected as the spatial scale. At this level, TB incidence was closely associated with most socioeconomic variables (0.31 < r < 0.76, P < 0.01). Of five environmental factors, only the concentration of fine particulate matter displayed significant correlation (r = 0.21, P < 0.05). Similarly, in terms of q values derived from the GD, socioeconomic variables had stronger explanatory abilities (0.08 < q < 0.57) for the spatial differentiation of the 2017 incidence of TB than environmental variables (0.06 < q < 0.27). Moreover, a much larger proportion (0.16 < q < 0.89) of the spatial differentiation was interpreted by pairwise interactions, especially those (0.60 < q < 0.89) related to the 2016 incidence of TB, officially appointed medical institutions, bus stops, and road density.

Conclusions
The spatial heterogeneity of the 2017 incidence of TB in the study area was considerably influenced by several socioeconomic and environmental factors and their pairwise interactions on a fine scale. We suggest that more attention should be paid to the units with pairwise interacting factors in Guangzhou. Our study provides helpful clues for local authorities implementing more effective intervention measures to reduce TB incidence in China’s municipal areas, which are featured by both a high degree of urbanization and a high incidence of TB.

Graphical Abstract
Sexual attraction to men as a risk factor for eating disorders: the role of mating expectancies and drive for thinness
Authors: Ruiz de Assin Varela Pedro María , Caperos Jose Manuel , Gismero-González Elena 
Published: April 2022

Abstract
Background
Men tend to give more importance than women to physical aspects when selecting a partner; thus, the internalization of beauty standards and the ideal of thinness may be greater in populations attracted to men, placing them at a higher risk of eating disorders.

Methods
In a sample (n = 398) of heterosexual and gay men and women, we evaluated the drive for thinness, body dissatisfaction, and bulimic symptomatology. Using ANCOVAs, we analyzed the differences in symptoms score according to sex, sexual orientation and relational status including body mass index (BMI) as covariate; we also evaluated the mediating role of drive for thinness in the relationship between sexual orientation and body dissatisfaction.

Results
We found an increased drive for thinness and body dissatisfaction in men-attracted compared with women-attracted participants; also, body dissatisfaction was greater in women than in men. Heterosexual women presented higher bulimia scores than lesbian women. Gay men open to relationships presented higher drive for thinness and body dissatisfaction scores than those not-open to relationships. Finally, differences in body dissatisfaction between gay and heterosexual men were fully explained by drive for thinness, while, in the case of women, drive for thinness only partially explained these differences.

Conclusions
Attraction to men seems to be a risk factor for EDs in the case of gay men and heterosexual women. In addition, in the case of heterosexual women, other factors independent of the desire to attract men seem to be important.
How genetic analysis may contribute to the understanding of avoidant/restrictive food intake disorder (ARFID)
Authors: Kennedy Hannah L. , Dinkler Lisa , Kennedy Martin A. , Bulik Cynthia M. , Jordan Jennifer 
Published: April 2022

AbstractAvoidant/restrictive food intake disorder (ARFID) was introduced in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Unlike anorexia nervosa, ARFID is characterised by avoidant or restricted food intake that is not driven by weight or body shape-related concerns. As with other eating disorders, it is expected that ARFID will have a significant genetic risk component; however, sufficiently large-scale genetic investigations are yet to be performed in this group of patients. This narrative review considers the current literature on the diagnosis, presentation, and course of ARFID, including evidence for different presentations, and identifies fundamental questions about how ARFID might fit into the fluid landscape of other eating and mental disorders. In the absence of large ARFID GWAS, we consider genetic research on related conditions to point to possible features or mechanisms relevant to future ARFID investigations, and discuss the theoretical and clinical implications an ARFID GWAS. An argument for a collaborative approach to recruit ARFID participants for genome-wide association study is presented, as understanding the underlying genomic architecture of ARFID will be a key step in clarifying the biological mechanisms involved, and the development of interventions and treatments for this serious, and often debilitating disorder.
The association between sense of coherence and quality of life: a cross-sectional study in a sample of patients on hemodialysis
Authors: Sawma Toni , Sanjab Yara 
Published: April 2022

Abstract
Background
Patients on hemodialysis universally experience detriments in their general quality of life (QOL). Sense of coherence (SOC) is a long-standing factor that affects QOL. Nevertheless, the association between SOC and QOL in patients on hemodialysis was seldom investigated. Our research aims to study this association in a sample of Lebanese adult patients on hemodialysis.

Methods
In this cross-sectional study, SOC was measured using the short version of the “Orientation of Life" scale (SOC-13). QOL was assessed using the Kidney Disease Quality of Life- Short Form (KDQOL-SF). The association between SOC and QOL and its submodalities was first explored using Pearson Correlation and multivariate linear regression analyses, controlling for sociodemographic variables and medical variables.

Results
157 patients on hemodialysis (mean(SD) age: 62.1(13.81) years; 58.6% males) were included. Mean QOL score was 51.65 and that of SOC was 48.06. SOC was strongly corrected with the total QOL (r = 0.832; p value < 0.001), as well as its physical functioning (r = 0.767; p value < 0.001), emotional functioning (r = 0.757; p value < 0.001), cognitive functioning (r = 0.740; p value < 0.001), and social functioning (r = 0.773; p value < 0.001) submodailties. SOC was moderately correlated with professional functioning submodality of QOL (r = 0.618; p value < 0.001), but not correlated with the satisfaction with the quality of care (r = 0.052; p = 0.520). Within the regression models accounting for sociodemographic and medical variables, SOC was significantly associated with the total QOL (unstandardized B = 0.803; 95% CI 0.714, 0.893), physical functioning (unstandardized B = 0.761; standardized B = 0.763; 95% CI 0.661, 0.861), emotional functioning (unstandardized B = 1.205; standardized B = 0.757; 95% CI 1.037, 1.372), professional functioning (unstandardized B = 1.142; standardized B = 0.498; 95% CI 0.843, 1.442), cognitive functioning (unstandardized B = 1.239; standardized B = 0.739; 95% CI 1.058, 1.420), and social functioning (unstandardized B = 0.912; standardized B = 0.768; 95% CI 0.790, 1.034).

Conclusions
In a sample of adult patients on hemodialysis, SOC was positively significantly associated with QOL and its submodalities, expect the satisfaction with the quality of care. The confirmation of the general hypothesis that relates the SOC with the QOL encourages more salutogenic research among this patient population.
Examination of three-factor eating questionnaire subscale scores on weight loss and weight loss maintenance in a clinical intervention
Authors: Papini Natalie M. , Foster Rachel N. S. , Lopez Nanette V. , Ptomey Lauren T. , Herrmann Stephen D. , Donnelly Joseph E. 
Published: April 2022

Abstract
Background
The purpose of this study is to examine three-factor eating questionnaire (TFEQ) scores at baseline and post-intervention (6 months) on successful weight loss and weight maintenance in an 18-month behavioral weight management intervention for adults with overweight and obesity.

Methods
TFEQ and weight were assessed at baseline, 6, and 18 months. Logistic regression models were used to examine scores at baseline on disinhibition, restraint, and perceived hunger factors in the TFEQ on 5% body weight loss at 6 months and 6-month scores to predict 5% weight maintenance at 18 months while controlling for age, sex, and baseline weight.

Results
Participants (n = 287; age = 43.8 ± 10.36 years; female = 64.1%; weight = 222.5 ± 39.02 pounds; BMI = 34.73 ± 4.56) were included for analysis. Dietary restraint at baseline was the only significant predictor of 5% weight loss at 6 months. None of the TFEQ subscale scores at 6 months predicted 5% weight maintenance at 18 months. The model examining weight loss at 6 months accounted for 7% of the variance of the outcome and 11% of the variance of weight maintenance at 18 months.

Conclusion
Dietary restraint is a unique eating behavior associated with weight loss at 6 months beyond other eating behaviors measured by the TFEQ in an adult sample enrolled in a weight loss intervention. No other subscale scores were significant at 6 months or at 18 months. Future research should consider how to promote flexible control and discourage adoption of rigid restraint behaviors since the latter is associated with disordered eating patterns.
Environmental and anthropogenic influences on movement and foraging in a critically endangered lemur species, Propithecus tattersalli: implications for habitat conservation planning
Authors: Semel Meredith A. , Abernathy Heather N. , Semel Brandon P. , Cherry Michael J. , Ratovoson Tsioriniaina J. C. , Moore Ignacio T. 
Published: April 2022

AbstractBackgroundWildlife conservation often focuses on establishing protected areas. However, these conservation zones are frequently established without adequate knowledge of the movement patterns of the species they are designed to protect. Understanding movement and foraging patterns of species in dynamic and diverse habitats can allow managers to develop more effective conservation plans. Threatened lemurs in Madagascar are an example where management plans and protected areas are typically created to encompass large, extant forests rather than consider the overall resource needs of the target species.MethodsTo gain an understanding of golden-crowned sifaka (Propithecus tattersalli) movement patterns, including space use and habitat selection across their range of inhabited forest types, we combined behavior data with Dynamic Brownian Bridge Movement Models and Resource Selection Functions. We also examined the influence of abiotic, biotic, and anthropogenic factors on home range size, movement rates, and foraging patterns.ResultsWe found that home range size and movement rates differed between seasons, with increased core area size and movement in the rainy season. Forest type also played a role in foraging behavior with sifaka groups in the humid forest avoiding roads in both seasons, groups in the dry deciduous forest avoiding road networks in the rainy season, and groups in the moderate evergreen forest displaying no selection or avoidance of road networks while foraging.ConclusionOur study illustrates the importance of studying primate groups across seasons and forest types, as developing conservation plans from a single snapshot can give an inaccurate assessment of their natural behavior and resources needs of the species. More specifically, by understanding how forest type influences golden-crowned sifaka movement and foraging behavior, conservation management plans can be made to the individual forest types inhabited (dry deciduous, moderate evergreen, humid, littoral, etc.), rather than the region as a whole.
Identifying barriers to care for complex airway disease and multidisciplinary solutions to optimize therapy in Canada
Authors: Cherukupalli A. , Yong M. , Chan Y. , Desrosiers M. , Thamboo A. 
Published: April 2022

Background Complex airway disease such as Chronic Rhinosinusitis with Asthma or Aspirin Exacerbated Respiratory Disease requires a multidisciplinary approach to management and treatment. Many centers in the USA have created collaborative multidisciplinary clinics to support the management of these patients; however, similar structures do not appear to exist in Canada. Methods This mixed methods study used a combination of structured interviews and a cross-sectional national survey. Interviewees included members of the Canadian Rhinology Working Group and survey participants were a combination of academic and community Rhinologists, Respirologists and Allergists. All participation was voluntary and selection criteria was based on their involvement in treating complex airway disease. Our objective was to identify the current state of diagnosis and treatment of complex airway patients in Canada between Rhinology, Respirology and Allergy and understand the barriers, challenges and propose solutions to establishing a multidisciplinary airway clinic in Canada. Results Four Rhinologists participated in qualitative interviews and a convenience sample of 42 specialists through our known network responded to our quantitative survey. From our survey, 54.8% believed multidisciplinary clinics were necessary in the management of complex airway disease, providing better outcomes and cost-savings (69%, 45.2%). Most specialties agreed that history, physical, pulmonary function and skin prick testing was important for diagnosis (92.9%, 92.9%, 88.1%). If clinicians were to participate in a multidisciplinary clinic, they would be willing to forego an average of 14.2% of their mean daily income for that clinic. The ideal clinic location was split between a neutral shared location vs. a Rhinology clinic space (38.1%, 45.2%). Conclusions Complex airway diseases are currently managed in subspecialty silos resulting in fragmented care. Our study highlights gaps in management, areas for improvement and support for establishing multidisciplinary complex airway disease clinics in Canada to better treat this population.
Primary palliative care recommendations for critical care clinicians
Authors: Ito Kaori , George Naomi , Wilson Jennifer , Bowman Jason , Aaronson Emily , Ouchi Kei 
Published: April 2022

AbstractPalliative care is an interdisciplinary care to optimize physical, psychosocial, and spiritual symptoms of patients and their families whose quality of life is impaired by serious, life-limiting illness. In 2021, the importance of providing palliative care in the intensive care unit (ICU) is well recognized by various studies to alleviate physical symptoms due to invasive treatments, to set patient-centered goals of care, and to provide end-of-life care. This paper summarizes the evidence known to date on primary palliative care delivered in the ICU settings. We will then discuss the potential benefits and harms of primary palliative care so that critical care clinicians are better equipped to decide what services might best improve the palliative care needs in their ICUs.