bluuebunny/crossref_metadata_2025_split huggingface dataset:
“These are people just like us who can work”: Overcoming clinical resistance and shifting views in the implementation of Individual Placement and Support (IPS)
Authors: Sharek Danika , Lally Niamh , Brennan Ciara , Higgins Agnes 
Published: July 2022

Abstract
Purpose
Individual Placement and Support (IPS) is a recovery-based approach to support people with mental health difficulties back into employment. Embedding of IPS within the mental health Multi-Disciplinary Team (MDT) is a key component of IPS fidelity; however, few studies have examined how those involved with IPS implementation navigate this process. This article explores how IPS Employment Specialists (ES) and Occupational Therapist (OT) Managers integrated and embedded IPS within traditionally-oriented MDTs as part of a national reform program in the Republic of Ireland.

Methods
The study design was qualitative, descriptive with data collected through three focus groups with 17 IPS ESs and 11 OT Managers. Data were analyzed using thematic synthesis.

Results
Three key themes emerged from analysis. The first characterizes the context into which IPS landed, described as one marked by clinical resistance, doubt, and fear of risk. The second explores the strategies and factors that helped with the introduction of IPS into Irish mental health services. These included strategies, such as providing education and information about IPS and reassuring the MDT about IPS governance and IPS ES’ competencies. The evidenced-based nature of IPS and its attached accountabilities through IPS fidelity measures were perceived to be an important factor in its acceptance. The final theme encapsulates perceptions of how IPS impacted on the MDTs’ views of people with mental health difficulties. Findings suggest a shift in the ways in which MDTs view their clients. Initial fears about work capacity and risk shifted towards seeing people beyond the label of ‘service user’ and their diagnosis.

Conclusions
It is contended that IPS is an approach that allows practitioners to engage with real recovery-practice and may be one key to unlocking how a recovery approach can truly trickle down and embed itself within mental health service provision and support mental health system reform.
Sensitivity of river catchments to discharge-controlled dissolved carbon export: a study of eight catchments in southern Patagonia
Authors: Pérez-Rodríguez Marta , Biester Harald 
Published: July 2022

AbstractUnderstanding the role of catchment sensitivity to dissolved carbon export to aquatic systems is crucial to predict future changes in carbon fluxes under changing climatic conditions. We present 1-year variations in dissolved organic (DOC) and inorganic carbon (DIC) concentrations and fluxes in eight river catchments differing in size (3–300 km2), morphology (steep to flat), and vegetation cover (grassland, forest and peatland) along a precipitation gradient in southern Patagonia, Chile. The results show large differences between catchments in terms of river DOC (2–47 mg L−1; 1–44 tons km−2 year−1) and DIC (0.1–38 mg L−1; 1–5 tons km−2 year−1) concentrations and fluxes in response to changes in discharge. Small and steep catchments hosting organic rich forest soils and peatlands were the most sensitive and showed the highest and fastest DOC release if evaluated on a per unit area basis. Here, rain events caused a rapid exponential increase in DOC release, while DIC export decreased exponentially. A negative correlation between DOC and DIC reveals the minor importance of DIC production through mineralization of DOC in most catchments. Catchments hosting large peatlands had low sensitivity to discharged controlled DOC release attributed to their high hydrological buffer capacity. Similarly, flat and relatively dry Patagonian steppe catchments have comparatively low sensitivity but have short-term high release of DOC accumulated during dry periods. In conclusion, morphology, rather than catchment size or vegetation cover, was found to show the major influence on sensitivity to DOC release.
Changes in Internalizing Symptoms During the COVID-19 Pandemic in a Transdiagnostic Sample of Youth: Exploring Mediators and Predictors
Authors: Haller Simone P. , Archer Camille , Jeong Annie , Jaffe Allison , Jones Emily L. , Harrewijn Anita , Naim Reut , Linke Julia O. , Stoddard Joel , Brotman Melissa A. 
Published: July 2022

AbstractThe COVID-19 pandemic is a chronically stressful event, particularly for youth. Here, we examine (i) changes in mood and anxiety symtpoms, (ii) pandemic-related stress as a mediator of change in symptoms, and (ii) threat processing biases as a predictor of increased anxiety during the pandemic. A clinically well-characterized sample of 81 youth ages 8–18 years (M = 13.8 years, SD = 2.65; 40.7% female) including youth with affective and/or behavioral psychiatric diagnoses and youth without psychopathology completed pre- and during pandemic assessments of anxiety and depression and COVID-related stress. Forty-six youth also completed a threat processing fMRI task pre-pandemic. Anxiety and depression significantly increased during the pandemic (all ps < 0.05). Significant symptom change was partially mediated by pandemic stress and worries. Increased prefrontal activity in response to neutral faces pre-pandemic was associated with more intense parent-reported anxiety during the pandemic (all Fs(1.95,81.86) > 14.44, ps < 0.001). The present work extends existing knowledge on the mediating role of psychological stress on symptoms of anxiety and depression in youth.
Investigation of tracer gas transport in a new numerical model of lung acini
Authors: Schmidt Christoph , Joppek Christoph , Trinkmann Frederik , Takors Ralf , Cattaneo Giorgio , Port Johannes 
Published: July 2022

Abstract
Obstructive pulmonary diseases are associated with considerable morbidity. For an early diagnosis of these diseases, inert gas washouts can potentially be used. However, the complex interaction between lung anatomy and gas transport mechanisms complicates data analysis. In order to investigate this interaction, a numerical model, based on the finite difference method, consisting of two lung units connected in parallel, was developed to simulate the tracer gas transport within the human acinus. Firstly, the geometries of the units were varied and the diffusion coefficients (D) were kept constant. Secondly, D was changed and the geometry was kept constant. Furthermore, simple monoexponential growth functions were applied to evaluate the simulated data. In 109 of the 112 analyzed curves, monoexponential function matched simulated data with an accuracy of over 90%, potentially representing a suitable numerical tool to predict transport processes in further model extensions. For total flows greater than 5 × 10−4 ml/s, the exponential growth constants increased linearly with linear increasing flow to an accuracy of over 95%. The slopes of these linear trend lines of 1.23 µl−1 (D = 0.6 cm2/s), 1.69 µl−1 (D = 0.3 cm2/s), and 2.25 µl−1 (D = 0.1 cm2/s) indicated that gases with low D are more sensitive to changes in flows than gases with high D.
Graphical abstract
Reforming China’s fertilizer policies: implications for nitrogen pollution reduction and food security
Authors: Wang Xiaoxi , Xu Meng , Lin Bin , Bodirsky Benjamin Leon , Xuan Jiaqi , Dietrich Jan Philipp , Stevanović Miodrag , Bai Zhaohai , Ma Lin , Jin Shuqin , Fan Shenggen , Lotze-Campen Hermann , Popp Alexander 
Published: July 2022

AbstractReactive nitrogen (N) is a requisite nutrient for agricultural production, but results in greenhouse gas and air and water pollution. The environmental and economic impacts of N fertilizer use in China are particularly relevant, as China consumes the largest amount of N fertilizer in the world to meet its soaring food demand. Here, we use an agro-economic land system model (MAgPIE) in combination with a difference-in-differences econometric model to provide a forward-looking assessment of China’s fertilizer policies in terms of removing fertilizer manufacturing subsidies and implementing measures to improve agricultural nutrient management efficiency. Our model results indicate that enhancing soil N uptake efficiency and manure recycled to soil alongside fertilizer subsidy removal can largely reduce N fertilizer use and N losses and abate N pollution in the short and long term, while food security remains largely unaffected. Enhancing soil N uptake efficiency appears to be decisive to achieving China’s national strategic target of zero growth in N fertilizer use. This study also finds that improving agricultural nutrient management efficiency contributes to higher land productivity and less cropland expansion, with substantial benefits for the environment and food security.
Properties of Bounded Holomorphic Functions: A Survey
Authors: Jarnicki Marek , Pflug Peter 
Published: July 2022

AbstractWe discuss interrelations between $$\mathcal {H}^\infty $$

H

∞

-convex domains and $$\mathcal {H}^\infty $$

H

∞

-domains of holomorphy for various classes of domains in $$\mathbb {C}^{n}$$

C

n

.
Boosting the antimicrobial performance based on new fused spirothiazolidine framework analogs
Authors: El-Sofany Walaa I. , Flefel Eman M. , Darwesh Osama M. , El-Shahat Mahmoud 
Published: July 2022

AbstractNew spiro[cyclohexane-1,2'-thiazolo[4,5-b]pyridine derivatives (3–23) were investigated. Then there is in vitro antimicrobial potency against possible organisms Staphylococcus aurous ATCC-47,077, Bacillus cereus ATCC-12228, Escherichia coli ATCC-25922, Salmonella typhiATCC-15566, and Candida albicans ATCC-10231 were tested utilizing commercially available antibiotics ampicillin as a reference drug. A preliminary antimicrobial test represented that derivatives: (Aldoses) 3'-(4-fluorophenyl)-5'-(methyleneamino)-7'-(p-tolyl)-3'H-spiro[cyclohexane-1,2'-thiazolo[4,5-b]pyridine]-6'-carbonitrile (16–19) and (Acetyl aldoses) 3'-(4-fluorophenyl)-5'-(methyleneamino)-7'-(p-tolyl)-3'H-spiro [cyclohexane-1,2'-thiazolo[4,5-b]pyridine]-6'-carbonitrile (20–23) exhibited higher antifungal, and antibacterial performance with minimum inhibitory concentrations values of (39–67 µg/ml) toward all pathogenic strains compared to common reference drug ampicillin.
Atmospheric Emissions of Volatile Organic Compounds from a Mine Soil Treated with Sewage Sludge and Tomato Plants (Lycopersicum esculentum L.)
Authors: Fernández-Espinosa Antonio José , Peña-Heras Aránzazu , Rossini-Oliva Sabina 
Published: July 2022

AbstractThe study investigated the emissions of volatile organic compounds (VOCs) from a mining soil amended with sewage sludge and irrigated with wastewater with or without tomato plants. The aim is to find out whether amendment and irrigation change VOC emissions from the soil and whether tomato changes emissions compared to uncultivated soil. Soil and plant experiments were done in assembled pots. All pots were placed inside a closed glass chamber inside an isolated and windowless room. Experiments with soil without plants were done independently from experiments with soil and plants. An aspirating pump coupled with Tenax adsorbent tubes was used for sampling of VOCs emitted from pots. Volatile organic compounds trapped in the tubes were quantified by gas chromatography–mass spectrometry detection. The study detected a total of nine VOCs emitted from the polluted soil: benzene, toluene, ethylbenzene, p-xylene, m-xylene, o-xylene, styrene, benzene-1,2,4-trimethyl and tetrachloroethylene, among which the most abundant were toluene, m-xylene and styrene. Differences between pots with or without amendments (C and A-pots) showed a general tendency to a decline of VOCs emissions in the mining soil amended with sewage sludge. Plants contributed to increase significantly the emissions of all VOCs in both A and C-pots. The soil amended with sewage sludge reduced the emission of VOCs: styrene in pots without plants and benzene and xylenes in pots with plants. Tomato plants contributed to increase significantly the emissions of all VOCs except styrene in both amended and non-amended soils.
Nutritional Considerations in High Performance Youth Soccer: A Systematic Review
Authors: North Matthew , Kelly Adam L. , Ranchordas Mayur K. , Cole Matthew 
Published: July 2022

AbstractPurposeAs players in high performance youth soccer (HYPS) environments undergo large changes in growth and maturation throughout the course of their development, they require specific nutritional intakes if they are to meet these demands. The purpose of this review was to synthesise current nutritional research conducted within HYPS players.MethodsA systematic approach, following PRISMA guidelines, was employed to capture all articles related to nutrition within HPYS using the databases MEDLINE and SPORTDiscus. Study quality and risk of bias were assessed using a Downs and Black instrument. Observational and intervention studies which investigated an element of nutritional status, knowledge, or intervention in academy aged players (U9 to U23s) within HPYS settings were included.ResultsFifty-three articles qualified assessing: current nutritional intake and energy balance (n = 21); ergogenic aids/supplements (n = 13); hydration status (n = 6); the influence of Ramadan fasting (n = 4); Vitamin D status (n = 4); female HPYS players (n = 3); nutrition knowledge (n = 2). Outcomes demonstrate a large proportion of HPYS players exhibit insufficient energy and carbohydrate intake, and a lack sufficient periodisation of nutrition to account for varying training/match loads. Large variability in energy intake and expenditure exists between and within chronological age groups, indicating the potential impact on growth and maturation. Female HPYS data is lacking but indicates similar trends to male counterparts.ConclusionHYPS players do not currently meet their energy requirements however the impact of growth and maturation is not fully understood. Furthermore, within this demographic future research is required into the barriers and enablers of players achieving adequate energy intake.
Risk factors predicting the development of a pancreatic fistula following pancreaticoduodenectomy: A retrospective cohort study
Authors: Hassan Ramy A. , Zidan Ahmed , Jabir Murad A. , Abdelshafy Mohamed , Abdallah Mariam , Taha Ahmed M.I. 
Published: July 2022

ABSTRACT

Background:
A postoperative pancreatic fistula (POPF) following pancreaticoduodenectomy is considered a life-threatening complication. This study was designed to analyze the risk factors for the development of a POPF in a tertiary care center (Al-Rajhi Liver Hospital/Assiut University).

Patients and methods:
We retrospectively analyzed 96 patients who underwent pancreaticoduodenectomy at our hospital from January 2017 to December 2020. A pancreatic fistula was defined according to the 2016 update of the International Study Group of Pancreatic Fistula. The risk factors for a pancreatic fistula were analyzed via a univariate analysis and multivariate logistic regression analysis.

Results:
A clinically relevant pancreatic fistula was detected in 26/96 patients (27.1%) who underwent pancreaticoduodenectomy. The perioperative mortality rate was 8.3% (8/96 patients). Univariate analysis showed a significant association between the incidence of a POPF and the following factors: body mass index (BMI) (<28 vs. >28: 12% vs. 43.5%, respectively, p = 0.014), pancreatic consistency (firm vs. soft: 16.7% vs. 44.4%, respectively, p = 0.036), pancreatic duct diameter (>3 mm vs. <3 mm: 12.5% vs. 56.3%, respectively, p = 0.001), and drain amylase level POD 3 (p = 0.000). Multivariate logistic regression analysis identified BMI (p = 0.020), pancreatic consistency (p = 0.042), pancreatic duct diameter (p = 0.003), and drain amylase level (p = 0.003) as significant independent factors for a POPF. Using a ROC curve, the drain amylase level at POD 3 had the best sensitivity (92.3%) and specificity (82.9%) when using a cutoff value of 644 IU.

Conclusion:
Our study demonstrated that a BMI of >28, soft pancreatic texture, small pancreatic duct diameter of ≤3 mm, and drain amylase level at POD 3 (cutoff point = 644 IU) were the most significant risk factors for the development of a POPF following pancreaticoduodenectomy.

Highlights
Increased mass loss of glaciers in Volcán Domuyo (Argentinian Andes) between 1962 and 2020, revealed by aerial photos and satellite stereo imagery
Authors: Falaschi Daniel , Berthier Etienne , Belart Joaquín M. C. , Bravo Claudio , Castro Mariano , Durand Marcelo , Villalba Ricardo 
Published: July 2022

AbstractWe present geodetic mass-balance estimates for ten glaciers (22.6 ± 1.1 km2) around Volcán Domuyo between 1962 and 2020 (and 46 glaciers covering 29 ± 1.5 km2 between 1984 and 2020), derived from airborne, ASTER and Pléiades imagery. Overall, we find a slightly negative mass balance (−0.15 ± 0.09 m w.e. a–1) for the entire 1962–2020 time span. A closer inspection of sub-periods reveals, however, an increasingly negative mass balance with time. The Domuyo glaciers shifted from a moderately positive mass balance of +0.28 ± 0.13 m w.e. a–1 between 1962 and 1984, to a strongly negative mass balance of −0.99 ± 0.19 m w.e. a–1 between 2012 and 2020. An increase in summer temperatures and a decrease in winter precipitation during the last four decades are likely drivers of the observed glacier changes. We support this finding by implementing a minimal glacier model, relying solely on monthly precipitation and air temperatures. The mass-balance evolution detected in Volcán Domuyo is consistent with other sites spread across the Central Andes, suggesting rapidly increasing glacier wastage impacts are occurring at a geographically wider scale.
Grinding and crushing techniques in Africa Proconsularis
Authors: Souissi Skander 
Published: July 2022

AbstractThis article addresses the lack of literature on grinding and crushing techniques and its equipment in Africa Proconsularis. A new typology is presented, along with their geographical distribution. The types of stones used are also discussed, in relation to provenance, suitability and technological innovations. The conclusion questions what we know and what future research needs to address.
Mustis revisited: unpublished inscriptions from the Parisian archives
Authors: España-Chamorro Sergio 
Published: July 2022

Abstract EnglishThe Roman town of Mustis (municipium Iulium Aurelium Mustitanum) is near present-day Mest Henshir (Tunisia). Its epigraphic corpus has around 200 inscriptions mainly published at the end of the 19th century and the beginning of the 20th century, when the French archaeological campaigns took place. However, a group of Latin inscriptions discovered during the 1960s remained unpublished. In the reorganisation of the archives of the Institut National d'Histoire de l'Art (Paris) the original photographs, negatives, slides and documents revealed new data. In this article I present five new inscriptions (three votive texts, a quadruple funerary epitaph and a new boundary stone) and new data and photographs of three already known inscriptions published by G. Wilmanns in theCIL. All these texts reveal new data about the territory of theres publica Mustitana, the sacred life of the city (including the confirmation of a Capitol) and new onomastic information about its inhabitants.
l-Citrulline prevents heat-induced mitochondrial dysfunction and cell injury through nitric oxide-mediated Drp1 inhibition in mouse C2C12 myoblasts
Authors: Yu Tianzheng , Park Yu Min , Wang Li , Deuster Patricia A. 
Published: July 2022

AbstractSevere heat exposure causes mitochondrial fragmentation and dysfunction, which contribute to the pathogenesis of heat-related illness. l-Citrulline is a naturally occurring amino acid and has been suggested to influence heat shock responses. This study aimed to test whether l-citrulline supplementation would preserve mitochondrial integrity and attenuate heat-induced skeletal muscle injury and elucidate the underlying mechanisms. At 37°C, l-citrulline (2 mM) increased mitochondrial elongation in mouse C2C12 myoblasts, a process associated with a reduction in mitochondrial fission protein Drp1 levels. Mechanistic studies revealed that l-citrulline increased cellular nitric oxide (NO) levels, but not S-nitrosylation of Drp1. l-Citrulline caused a decrease in phosphorylation of Drp1 at Ser 616 and an increase in phosphorylation of Drp1 at Ser 637, which resulted in a reduced mitochondrial localisation of Drp1. L-NAME, a non-selective NO synthase inhibitor, abolished the increase in l-citrulline-induced NO levels and inhibited Drp1 phosphorylation changes and mitochondrial elongation, which indicates the involvement of a NO-dependent pathway. Under 43°C heat stress conditions, l-citrulline prevented translocation of Drp1 to mitochondria, mitochondrial fragmentation and decreased membrane potential. Finally, l-citrulline pretreatment inhibited heat-induced reactive oxygen species overproduction, caspase 3/7 activation, apoptotic cell death and improved cell viability. NO inhibitor l-NAME abolished all the above protective effects of l-citrulline under heat stress. Our results suggest that l-citrulline prevents heat-induced mitochondrial dysfunction and cell injury through NO-mediated Drp1 inhibition in C2C12 myoblasts. l-Citrulline may be an effective treatment for heat-related illnesses and other mitochondrial diseases.
Association between hyperhomocysteinaemia and the risk of all-cause and cause-specific mortality among adults in the USA
Authors: Zhao Wenyan , Lin Yan , He Huibo , Ma Honglei , Yang Wei , Hu Qian , Chen Xi , Gao Faliang 
Published: July 2022

AbstractHyperhomocysteinaemia (HHcy) is associated with all-cause mortality in some disease states. However, the correlation between HHcy and the risk of mortality in the general population has rarely been researched. We aimed to evaluate the association between HHcy and all-cause and cause-specific mortality among adults in the USA. This study analysed data from the National Health and Nutrition Examination Survey database (1999–2002 survey cycle). A multivariable Cox regression model was built to evaluate the correlation between HHcy and all-cause and cause-specific mortality. Smooth curve fitting was used to analyse their dose-dependent relationship. A total of 8442 adults aged 18–70 years were included in this study. After a median follow-up period of 14·7 years, 1007 (11·9 %) deaths occurred including 197 CVD-related deaths, 255 cancer-related deaths and fifty-eight respiratory disease deaths. The participants with HHcy had a 93 % increased risk of all-cause mortality (hazard ratio (HR) 1·93; 95 % CI (1·48, 2·51)), 160 % increased risk of CVD mortality (HR 2·60; 95 % CI (1·52, 4·45)) and 82 % increased risk of cancer mortality (HR 1·82; 95 % CI (1·03, 3·21)) compared with those without HHcy. For unmeasured confounding, E-value analysis proved to be robust. In conclusion, HHcy was associated with high risk of all-cause and cause-specific (CVD, cancer) mortality among adults aged below 70 years.