bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, spectral characterization and biological activities of Ag(I), Pt(IV) and Au(III) complexes with novel azo dye ligand (N,N,O) derived from 2-amino-6-methoxy benzothiazole
Authors: Kyhoiesh Hussein A. K. , Al-Adilee Khalid J. 
Published: January 2022

Abstract
The novel ligand 2-[2'-(6-methoxybenzothiazolyl)azo]-3,5-dimethyl benzoic acid (6-MBTAMB), derived from 2-amino-6-methoxy benzothiazole, has been used to synthesize a series of new metal complexes of Ag(I), Pt(IV) and Au(III). The metal complexes were characterized by elemental analyses (CHNS), molar conductivity, crystal structure (XRD), spectroscopic techniques: FT-IR, 1H NMR, 13C NMR, UV-Vis, mass spectra, thermal analysis (TG-DTA), FE-SEM and magnetic properties. Results confirmed that the azo dye ligand behaves a tridentate and coordinates to the metal ion via nitrogen atom of azomethine group of heterocyclic benzothiazole ring, nitrogen atom of the azo group which is the farthest of the benzothiazole molecule and carboxylic oxygen. Antimicrobial properties of all newly synthesized azo compounds are also demonstrated against bacterial pathogenic organisms and fungi. These complexes are more effective against bacteria and less effective against fungi compared to standard antibacterial drugs (Novobiocin) and antifungal drugs (Cycloheximide). By using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging test, it was discovered that the complexes had good antioxidant properties. In addition, the (6-MBTAMB) and metal complexes were docked with the crystal structure of FGF Receptor 2 (FGFR2) kinase domain harboring the pathogenic gain of function K659E mutation identified in endometrial cancer using the Molecular Operating Environment module (MOE). In vitro studies on human endometrial cancer cell lines (MFE-296) as well as healthy human umbilical vein endothelial cells (HUVEC) show uptake of the intact compounds by the cancer cells and increased activity against the cancer cells.
The Lithium (Li) Doping Effect for Enhancing Thermoelectric and Optoelectronic Performances of Co2NbAl
Authors: Djillali Bensaid , Bendouma Doumi , Ahmad Sohail 
Published: January 2022

Abstract
Cobalt -rich Heusler compounds represent a very interesting family among Heusler alloys due to their performance in the field of spintronics and magnetic devices. The quaternary Heusler created by swapping of an anti-atom site by an alkali element improves the performance of physical properties for new applications. In this study, the electronic structures and magnetic properties before and after swapping cobalt (Co) by lithium (Li) in the Co2NbAl compound have been investigated using first-principle computational calculations. Our findings revealed that the swapping Co antisite by Li keeps the half-metallic character in the CoLiNbAl. Analysis of band structures show that ternary Heusler compound is ferromagnetic half-metallic with half metallic gap (band gap in minority channel ) equal 0.134 eV but the swapping Co with Li leads the material to change its behavior and becomes a semiconductor with a gap equal 1.043 eV using HSE06 approach. The results of optical and thermoelectric properties such as absorption coefficient, reflectivity or thermopower and figure of merit are very interesting in the optoelectronic field and encourages the researchers to realize photovoltaic cell and thermoelectric generator with a higher efficiency. These interesting features suggest that Co2NbAl and LiNbAlCo Heusler compounds could be good candidates for applications of antiferromagnetic spintronics and optoelectronics in commercial semiconductor industry.
Farmer Preference to High Elevation Rice Technological Packages for Accelerating Technological Dissemination (A case Study in Humbang Hasundutan Regency)
Authors: Girsang Setia Sari , Santosa Agung B , Purba Tommy , Siagian Deddy R , Ramija Khadijah E 
Published: January 2022

Accelerating the introduction of a new technological package is needed to increase the productivity of high elevation puddled rice in Humbang Hasundutan. The objectives of the study are to find out the perception of the existence of technological packages and farmers' preference for a new technological package. The study used a survey method with primary data gathered using questionnaires. The criteria of locations and respondents were used to obtain relevant respondents and data concerning their knowledge of high elevation puddled rice cultivation. The collected data were processed by using Importance Performance Analysis in order to find out the level of Importance and Satisfaction of the indicators and the valued aspects in the technological package components. The results of the study showed that the socio-economic aspects had to be heeded in organizing the technological package. Indicators having a high level of importance and a low level of satisfaction consisted of production cost, quality of seeds, farmer groups empowerment, technology information institution, capital cost, agricultural tools and machines, pest control, sales price, irrigation canals, and farm roads. On the other hand, introducing new superior seeds, productivity attribute and planting age were important indicators for local farmers as to improve the quality of existing seeds. Farmers group expected that the technological package had a high level of productivity, better access to input, low cost, and good user-friendliness in its application.
Development of Analytical Profile of Lamotrigine and its API Formulation
Authors: VISHAL CHAUDHARY  , SAXENA VASUNDHARA 
Published: January 2022

Objective: The objective of this review is to put a light on the development of lamotrigine and its active pharmaceutical ingredients formulation with proper demonstration.
Method: In the present work, one of the most imperative spectrophotometric method which is RP-HPLC method has been developed for the quantitative estimation of lamotrigine in bulk and pharmaceutical formulations.
UV spectrophotometric method which involves the determination of Lamotrigine in bulk and in bulk drug and pharmaceutical formulation has maximum absorption at 307.5nm in methanol. It obeys Beer’s and Lambert’s law in the concentration range of 5-45 µg/ml.
A rapid and sensitive RP- HPLC Method with UV detection (270 nm) for routine analysis of Lamotrigine formulation was developed. Chromatography was performed with mobile phase containing a mixture of methanol and Phosphate buffer (65:35v/v) with flow rate 1.0 ml/min. In the range of 20-100 µg/ml, the linearity of lamotrigine shows a correlation co-efficient of 0.9998. The proposed method was validated by determining sensitivity and system suitability parameters.
Epidemiological significance of microbiote monitoring of arctic settlements along the Northern Sea Route
Authors: Kraeva L. A. , Panin A. L. , Goncharov A. E. , Belov A. B. , Vlasov D. Yu. , Kirtsideli I. Yu. , Goncharov N. E. , Baranov I. V. , Sboychakov V. B. 
Published: January 2022

Monitoring of polar ecosystems is one of the most important areas of research in the use of Arctic territories in economic activities. An important place in such work is occupied by biomedical research aimed at identifying the risks of the occurrence of foci of infectious diseases in the areas of polar settlements.The purpose: to develop an algorithm for microbiological monitoring in the Arctic region.Materials and methods: classical bacteriological, mycological research, molecular-genetic, MALDI-TOF mass spectrometric analysis, phenotypic methods for determining antibiotic resistance, methods of mathematical data processing.Results and their discussion. The paper considers the scientific and methodological principles and the main stages of microbiota monitoring in the areas of polar settlements. The results of the study of samples from several territories along the Northern Sea Route are presented. The main habitats where potentially dangerous microorganisms should be detected are indicated. The role of anthropogenic invasion in the formation of Arctic microbiocenoses is noted. The trends of increasing the number and diversity of pathogenic microorganisms, both in the natural biocenoses of the Arctic and in the areas of polar settlements, are discussed. The necessity of microbiological monitoring as an integral part of epidemiological monitoring in the areas of Arctic settlements along the Northern Sea Route is substantiated.
Gum recession as a medical and social problem of marine medicine
Authors: Iordanishvili A. K. , Serikov A. A. 
Published: January 2022

Introduction. An important role in ensuring the aesthetics of the face and smile is played by the integrity of the teeth, dentition, the absence of dentoalveolar anomalies, as well as periodontal health, including the presence of gum recessions. If there are separate publications for inflammatory periodontal diseases in the crew, then there is no information on the occurrence of gum recessions in the crew.The aim of the study was to study the incidence of gingival recessions in the crew, to assess the features of their clinical course and the possibility of eliminating them during the voyage.Material and methods. To identify gingival recessions and the peculiarities of their clinical course after oral sanitation and before a long sea voyage, a dental examination was carried out on 156 men aged 22 to 52 years, who were divided into 2 groups: young (group 1, 105 people) and middle (group 2, 51 people) age. To determine the type of gum recession in the crew, the generally accepted Miller classification was used.Results and its discussion. The high incidence of gingival recessions among the ship crew was determined, amounting to 33,97%. It was found that gum recessions are more often detected in middle-aged sailors (72,55%) than in young sailors (15,24%). Regardless of the age group of sailors, most often, in 90,57% of cases, there were such clinical forms of gum recessions (I, II and III A classes), with surgical removal of which a favorable treatment result is noted.Conclusion. The recession of the gums in the ship’s crew is a medical and social problem, which can be solved during a long sea voyage with the presence of a specialist — a dentist-surgeon.
Features of clinical symptom and inflammatory marker regression in the use of thermal oxygen-helium mixture in SARS-CoV-2 pneumonia treatment
Authors: Manuilov V. M. , Mukhamedzhanova A. R. 
Published: January 2022

New coronavirus infection is accompanied by high mortality and socio-economic losses in the world community. Despite the continuous process of including new medication with antiviral and anti-inflammatory effects in the disease treatment, the development of complications, primarily of hypoxic origin, and mortality remain high.The aim of the study is to evaluate the effect of the use of thermal oxygen-helium mixture in the therapy on the rate of regression of clinical and laboratory signs of inflammation, as well as the length of patient hospital stay.Material and methods. 59 patient medical records with moderate and severe disease were analyzed. The article summarizes experience of patient management with COVID-19-associated pneumonia who are treated with or without the use of thermal oxygen-helium mixture in one of intensive care units in multi-filed hospital.Results and discussion. It has been proven that the use of a thermal oxygen-helium mixture in the SARS-CoV-2 pneumonia treatment is effective.
Assessment of the pathogenesis of visual impairment naval specialists of the arctic zone of the russian federation during the polar night
Authors: Zhekalov A. N. , Mishin I. Yu. 
Published: January 2022

Introduction. The climatogeographic conditions of the Arctic Zone of the Russian Federation are determined by the proximity to the North Pole of the Earth and are characterized by a number of certain cyclical changes that do not take place in the middle latitudes — the polar day and the polar night. The high-latitude location determines the long period of the polar night, lasting from 98 to 133 days. Being the hallmark of the Arctic, the polar night is an integral part of service in the Arctic region, it has an impact on every geographically involved person, without exception.Purpose of work. To assess the mechanisms of the pathogenesis of visual impairment that develop during the polar night in naval specialists.Materials and research methods. The study involved 92 people. The surveyed contingent is male contract servicemen of the Navy, aged from 21 to 45 years. The analysis of the morbidity structure according to the ophthalmological profile was carried out during the polar night from November 20, 2020 to January 20, 2021 using an epidemiological method of a case-control study. The assessment of unfavorable climatic and geographical factors of the Arctic region during the polar night was carried out by the method of analytical observation and data recording from November 20, 2020 to January 20, 2021 using the example of the Novaya Zemlya archipelago, Belushya Guba village. On the basis of an integral analysis of epidemiological indicators, climatogeographic and clinical and morphological observations, a pathophysiological assessment of diseases of the organ of vision, developing during the polar night in naval specialists, was carried out.Research results show a high level of ophthalmological morbidity during the polar night among naval specialists serving on the Novaya Zemlya archipelago.Conclusions. Climatogeographic factors of the Arctic region have a polyetiological effect on the formation of mechanisms of pathogenesis of disorders of visual functions that develop in naval specialists during the polar night.
Management of Localized Anterior Tooth Wear Using a Modified Sandwich Technique and the Dahl Concept: A Case Report
Authors: Lim TW , Roffie J 
Published: January 2022

SUMMARY
This case report illustrates a minimally invasive segmental rehabilitation of localized anterior tooth wear using a modification of the sandwich technique, a combination of indirect palatal composite veneers and direct labial composite restorations, at an increased occlusal vertical dimension (the Dahl concept).
A Study of Process Skills in Mathematics: Elementary School and Madrasah Ibtidaiyah
Authors: Yantoro Yantoro , Syahrial Syahrial , Perdana Rahmat , Rahman Adriyan Ardi 
Published: January 2022

Mathematics is learning that uses many numbers, so that many students do not like mathematics. Other research also states that students find it difficult to learn mathematics. The purpose of this is to compare and relate the skills of elementary school students and Islamic school students to the material. This study uses quantitative methods with associative and comparative types. The population in this study were 36 students in each school. The research instrument for students' process skills between SD (Elementary School) and MI (Madrasah Ibtidaiyah) on mathematics lessons. This study tested the statistics after performing statistical tests and assumption tests in normality tests, homogeneity tests, and linearity tests. The study results are that the data of SD and MI students are said to be expected, and the data are homogeneous, and there is a linear relationship between SD and MI students. There is a process of student skills between students in SD (Elementary School) and MI (Masrasah Ibtidaiyah) in learning mathematics. The correlation test results for each school shows that student responses affect students' learning process skills.
Evaluation of crack resistance of welded joints with soft interlayers
Authors: Molokov K. A. , Novikov V. V. 
Published: January 2022

Introduction. Welded joints in large-sized metal structures (e.g., in the structures of ship hulls) subject to low-cycle fatigue are considered. The characteristic appearance of soft interlayers, which are significantly plastically deformed under working loads, was noted. Deformation of the metal structure with damage, especially in the form of cracks, reduces the strength and reliability of structural elements and joints. Pre-deformation negatively affects plasticity; therefore, much depends on the residual plasticity of the cracking material. At the same time, with a decrease in residual plasticity, such an important reliability indicator as the resistance of the material to crack propagation — the fracture toughness – decreases. The paper is devoted to the development of a model that includes analytical dependences for assessing the crack resistance of metal structures and their welded joints with soft interlayers according to the crack resistance limit for all crack sizes.Materials and Methods. The theory and methods of linear mechanics of materials destruction, structural-mechanical approach are used. The calculation results were analyzed and compared to the experimental data and other analytical solutions. The numerical experiment was performed for the ferrite-perlite steel grades of 10, 50, 22K, St3sp, etc., widely used in industry, as well as for alloy steels hardened to medium and high strength of 30KhGSA, 37KhN3A, etc. Results. Analytical dependences are obtained for calculating the relative crack resistance limit according to three main known mechanical characteristics of the state of the material of the soft interlayer of the welded joint.Discussion and Conclusions. The results obtained can be used to assess the crack resistance of pre-deformed structural elements and welded joints (including those with soft interlayers) operating under a transverse load. The results of experimental data and analytical calculations are shown in dimensionless form, which enables to obtain invariant results with respect to the fracture toughness limit.
Synchronization in multi-motor hydromechanical systems
Authors: Rybak A. T. , Ivanovskaya A. V. , Batura P. P. , Pelipenko A. Yu. 
Published: January 2022

Introduction. The paper submits the analysis of existing design solutions of flow dividers used to synchronize hydraulic drives of working bodies of technological and mobile machines. The market demands for multithreaded throttle flow dividers without valves with the controlled division ratio, such as multi-axle vehicle chassis, are identified. The objective of the work was to analyze the possibility and rationale for developing a throttle four-way flow divider without valves with sensing elements of the Venturi tube type. The solution should provide the synchronicity of movement (rotation) of more than three working bodies of technological and mobile machines.Materials and Methods. A patent search for the designs of hydraulic flow dividers is carried out, and systems that require the division of the hydraulic fluid flow into more than two executive bodies are considered. An upgrade option, which allows dividing the flow into four branches, is proposed for the design of a three-channel throttle flow divider without valves.Results. The urgency of developing a multithreaded throttle flow divider without valves for application in industrial and mobile machines is validated. Two types of four-flow dividers are considered, their weaknesses are indicated. It is noted that the development of a multithreaded throttle flow divider based on the designs created in 1989 and 1991 will reduce the number of hydraulic pumps and get rid of the series connection of double-flow dividers. In this way, it is possible to reduce pressure losses in the hydraulic system and implement adaptive control of hydraulic motors of multi-motor mobile machines. The possibility to obtain a divider/combiner into four flows by adding an outlet chamber connected to the membrane chamber through a channel entering the Venturi nozzle on the basis of a three-flow throttle divider is shown. The principle of operation of such equipment is described.Discussion and Conclusions. The principles of construction of throttle flow dividers without valves are considered. An upgrade option is proposed to increase the number of division channels from three to four. However, to validate the operability of this design, a numerical analysis of the various modes of operation of the divider is required — calculation of the reduced volumetric stiffness of its working cavities. The information obtained can be used to modernize the hydraulic units of technological and mobile machines, increase their reliability, manufacturability, and efficiency. The issues that need to be solved in further research are identified.
Machine Learning and data mining tools applied for databases of low number of records
Authors: Anysz Hubert 
Published: January 2022

The use of data mining and machine learning tools is becoming increasingly common. Their usefulness is mainly noticeable in the case of large datasets, when information to be found or new relationships are extracted from information noise. The development of these tools means that datasets with much fewer records are being explored, usually associated with specific phenomena. This specificity most often causes the impossibility of increasing the number of cases, and that can facilitate the search for dependences in the phenomena under study. The paper discusses the features of applying the selected tools to a small set of data. Attempts have been made to present methods of data preparation, methods for calculating the performance of tools, taking into account the specifics of databases with a small number of records. The techniques selected by the author are proposed, which helped to break the deadlock in calculations, i.e., to get results much worse than expected. The need to apply methods to improve the accuracy of forecasts and the accuracy of classification was caused by a small amount of analysed data. This paper is not a review of popular methods of machine learning and data mining; nevertheless, the collected and presented material will help the reader to shorten the path to obtaining satisfactory results when using the described computational methods
Evaluation of the elastic modulus of pavement layers using different types of neural networks models
Authors: Elshamy M. M.M. , Tiraturyan A. N. , Uglova E. V. 
Published: January 2022

Introduction. This paper studies the capability of different types of artificial neural networks (ANN) to predict the modulus of elasticity of pavement layers for flexible asphalt pavement under operating conditions. The falling weight deflectometer (FWD) was selected to simulate the dynamic traffic loads and measure the flexural bowls on the road surface to obtain the database of ANN models.Materials and Methods. Artificial networks types (the feedforward backpropagation, layer-recurrent, cascade back- propagation, and Elman backpropagation) are developed to define the optimal ANN model using Matlab software. To appreciate the efficiency of every model, we used the constructed ANN models for predicting the elastic modulus values for 25 new pavement sections that were not used in the process of training, validation, or testing to ensure its suitability. The efficiency measures such as mean absolute error (MAE), the coefficient of multiple determinations R2, Root Mean Square Error (RMSE), Mean Absolute Percent Error (MAPE) values were obtained for all models results.Results. Based on the performance parameters, it was concluded that among these algorithms, the feed-forward model has a better performance compared to the other three ANN types. The results of the best four models were compared to each other and to the actual data obtained to determine the best method.Discussion and Conclusions. The differences between the results of the four best models for the four types of algorithms used were very small, as they showed the closeness between them and the actual values. The research results confirm the possibility of ANN-based models to evaluate the elastic modulus of pavement layers speedily and reliably for using it in the structural assessment of (NDT) flexible pavement data at the appropriate time.