bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical Model of Thermohaline Circulation in Land-Locked Basins: Analyzing the Impact of Friction on Circulation Reversal
Authors: Lazar Martin , Bubalo Maja , Begić Josip 
Published: June 2022

Abstract
The paper investigates switches of circulation orientation in inland basins, either at the surface or near the bottom. The study is based on an analytical 2D model used to simulate thermohaline circulation in lakes and inland seas. The model allows different density profiles varying in both horizontal and vertical directions. By assuming some simplifications (such as steady state, vanishing of an alongshore variability, and flat bottom), we are able to obtain an explicit expression of the circulation in the central transverse section of an elongated basin. Starting from three typical density profiles (bottom dense water, surface light water, and a combination of the two), the model reveals different circulation types (cyclonic and anticyclonic surface circulation, either prevailing along the whole vertical column or accompanied by an opposite circulation in the bottom layer). In addition, we analyze the impact of friction coefficients and basin dimensions on the switch from one circulation type to another. The simplified assumptions turn out not to be limiting, as other studies have shown that they do not change the main flow characteristics. More importantly, the results obtained are in keeping with empirical findings, numerical simulations, and physical experiments studied elsewhere.
Policy advice utilization in Belgian ministerial cabinets: the contingent importance of internal and external sources of advice
Authors: Squevin Pierre , Aubin David 
Published: June 2022

Ministerial cabinets hold a central place in the Belgian politico-administrative system, carrying out the bulk of policy formulation. However, they do not operate in isolation and rely on other actors of the policy advisory system for information supply and advice. They request, receive and use various advisory inputs. This article investigates how ministerial advisers utilize policy advice when they formulate policies. Based on a unique survey targeting ministerial cabinet members, it shows that policy advice utilization varies according to the source and its location in the policy advisory system. The sample consists of ministerial advisers from 11 ministerial cabinets in the two Belgian federated entities’ governments of Wallonia and the Wallonia-Brussels Federation. Ministerial advisers still predominantly use advice from the civil service, which points to the continued importance of advice provision from internal, in-house sources. However, advice from external actors – such as trade unions, civil society or consulting firms – have been observed to have rather high repercussions on policy formulation activities too. Advisory bodies appear to be very much active in supplying advice, but this same advice does not yield comparatively higher utilization scores. Points for practitioners This study focuses on policy advice utilization by members of ministerial cabinets in Belgium, especially when they formulate policies. It shows that internal, in-house sources remain important advice-providers and their advisory inputs still abundantly feed into the policy work carried out at the level of government. However, this article provides evidence that external sources might also supply advice that directly finds its way to decision-makers working in ministerial cabinets and that have considerable repercussions at that level too. This is the case for advice from trade unions, (organized) civil society or consulting firms, among others. Quite importantly for practitioners, our results suggest that ministerial advisers sometimes prefer controlling advisory exchanges and running separate consultations with one stakeholder at a time, instead of having to deal with collective, internal institutions that represent multiple interests, like advisory bodies. We did not observe striking differences in the degree of utilization between solicited and unsolicited advice, which means that for civil servants or stakeholders, sending policy advice previously unrequested by ministerial cabinets is not necessarily a fruitless strategy to follow.
The Ethics of Psychology Professors’ Behaviors: Perceptions From Both Sides of the Podium
Authors: Multhaup Kristi S. , Smith Dustin , Hunter Adam , Boyd Maurya M. , Tonidandel Scott 
Published: June 2022

Background Academic role (undergraduates, professors) and institutional context (liberal arts colleges, research universities) may affect how ethical psychology professors’ behaviors seem. Objective This study assessed whether academic role and institutional context related to ratings of professorial behaviors’ ethicality. Method A national sample ( N = 608) rated 70 professorial behaviors (e.g., unethical in virtually all circumstances to ethical in virtually all circumstances) across four domains: teaching, grading, relationships, and professional procedure. Results G-test of independence analyses yielded differences across academic role (student, professor) for 57% of teaching behaviors, 50% of grading behaviors, 63% of relationship behaviors, and 52% of professional procedure behaviors, although the difference was often a matter of degree rather than kind (ethical or unethical). Differences across institution type (liberal arts college, research university) were largest for relationship behaviors (25%) compared with teaching, grading, and policy behaviors (5%, 0%, 4%, respectively). Conclusion The data highlight the need for professors’ transparency and reinforce calls for the APA Ethics Code to consider context when defining ethical standards for psychologists’ behaviors. Teaching Implications The data set can enhance undergraduate education about the APA Ethics Code and spark discussion about sampling (e.g., limitations of this study are homogenous samples, including high-achieving undergraduates).
Just as Long as It’s Not an Essay: The Unessay as a Tool for Engagement in a Cognitive Psychology Course
Authors: Goodman Sara G 
Published: June 2022

Introduction Cognitive psychology courses are rich in content that can be useful to broad audiences. Much of the foundational research presented in course texts is conducted in highly constrained laboratory settings, making the concepts difficult to apply or use in the real world. Statement of the Problem Students in cognitive psychology classes may not readily notice practical applications for the content. Standard assessments (e.g. written research papers) fail to capture the real-world applications of cognitive phenomena. Literature Review Using an applied framework can motivate engagement in cognition. The use of an Unessay project in undergraduate cognitive psychology courses requires students to present a key construct in any format except an essay. Unessay projects originated in the humanities, and are an excellent fit for psychology. Teaching Implications The Unessay is a useful vehicle for identifying and presenting the application of a cognitive construct in the real world. Students are required to convey that information in a creative, non-essay format. Instructions, a rubric and examples are provided. Conclusion The Unessay is a novel approach to a course project in cognitive psychology that can motivate student interest while aligning with several APA outcomes for psychology majors.
Mitochondria transplantation/transfer between single cells
Authors: Hu Qin , Lu Jianfei , Zhang Xiaohua , Liu Ran , Yang Shao-Hua 
Published: June 2022

Mitochondrial transplantation/transfer has been increasingly recognized as a potential way for cell and tissue revitalization. In a recent study, Gabelein et al. reported a novel method for single cells mitochondria transplantation using “nanosyringe”. This technique combines atomic force microscopy, optical microscopy, and nanofluidics that enable intra- and intercellular organelle micromanipulation and cell-to-cell mitochondria transplantation with up to 95% success rate. The transferred mitochondria fuse to the host mitochondrial network and donor mtDNA incorporate into the recipient mitochondrial genome. The nanosyringe technique provides a novel tool for future mitochondrial research to offer insight into mitochondrial replacement therapy for stroke and fundamental mitochondrial biology.
Modified method of cervical conization with hybrid use of a cold knife and an electric knife for high-grade squamous intraepithelial lesions
Authors: Zhang Weifeng , Lin Yi 
Published: June 2022

Objective To evaluate the feasibility and surgical outcome of the modified method of cervical conization with hybrid use of a cold knife and an electric knife. Methods A retrospective analysis of cervical conization for high-grade squamous intraepithelial lesions was performed between January 2020 and December 2020. Traditional cold knife conization and modified conization were used. The clinical characteristics and surgical outcomes were compared between these methods. Results Ninety-two patients with high-grade squamous intraepithelial lesions were included. Traditional conization was performed in 46 patients, and the modified method was used in 46 patients. There were no differences in clinical characteristics, such as age, menopausal status, and conization height, between the methods. Intraoperative blood loss with the modified method was significantly lower than that with traditional conization (27.6 ± 4.7 vs 51.3 ± 18.3 mL). Postoperative vaginal bleeding requiring emergent measures, such as prolonged gauze compression, sutures, or electrocautery, was significantly less with the modified method than with traditional conization (4.3% vs 17.4%). A median follow-up of 10.2 months showed no significant difference in persistence or recurrence between the methods. Conclusions The modified method of cervical conization with hybrid use of cold and electric knives may be a good alternative to traditional cold knife conization.
Activation of STAT6 by intranasal allergens correlated with the development of eosinophilic chronic rhinosinusitis in a mouse model
Authors: Wei Hongqi , Xu Longjiang , Sun Peng , Xing Hongyu , Zhu Zhengwen , Liu Jisheng 
Published: June 2022

Eosinophilic chronic rhinosinusitis (ECRS) is a chronic inflammatory disease characterized by prominent eosinophilic infiltration along with a T-helper-2 (Th2) response. It has been well documented that signal transducer and activator of transcription 6 (STAT6) is a nuclear transcription factor that mediates Th2-type immunity and is implicatory of STAT1 and STAT3 in the pathogenesis of allergic airway diseases. However, little is known about the association between STATs and ECRS. Here, we explored the relationship between STAT1, STAT3, and/or STAT6 and eosinophilic inflammation accompanied by Th2-type immunity in a mouse model of ECRS. An ovalbumin (OVA)-staphylococcal enterotoxin B (SEB)-induced ECRS murine model was first established. The mucosal histological alterations were determined using hematoxylin and eosin staining. The number of eosinophils in peripheral blood was measured using a blood cell analyzer. The cytokine (IL-4, IL-5, IL17 A and IFN-γ) expression levels in the sinonasal mucosa and total and OVA-specific IgE from serum were measured using ELISA. Then, the protein levels of STAT1, STAT3, STAT6, phosphorylated STAT1 (p-STAT1), p-STAT3, p-STAT6, T-box expressed in T-cells (T-bet), GATA binding protein 3 (GATA-3), and retinoic acid receptor-related orphan receptor γ (RORγt) in the sinonasal mucosa were examined by immunohistochemical staining or Western blotting. Local administration of OVA combined with SEB (OVA + SEB) induced multiple polyp-like lesions, accompanied by prominent eosinophilic infiltration in the sinonasal mucosa. The OVA- and OVA+SEB-treated groups showed significantly higher eosinophil counts from peripheral blood and total and OVA-specific IgE levels from serum than those in the PBS- and SEB-treated groups. The levels of p-STAT6 were markedly increased by OVA + SEB exposure, as well as GATA-3, IL-4, and IL-5, but did not affect STAT6, p-STAT1, p-STAT3, T-bet, RORγt, IFN-γ, or IL-17A. Furthermore, an eosinophil count in the sinonasal mucosa showed a positive correlation with the level of p-STAT6 in the ECRS mouse model. Signal transducer and activator of transcription 6 signaling could be activated in the OVA+SEB-induced ECRS model and might be a crucial signal transducer in the development of Th2-skewed ECRS.
Whistle-blowers – morally courageous actors in health care?
Authors: Wiisak Johanna , Suhonen Riitta , Leino-Kilpi Helena 
Published: June 2022

Background Moral courage means courage to act according to individual’s own ethical values and principles despite the risk of negative consequences for them. Research about the moral courage of whistle-blowers in health care is scarce, although whistleblowing involves a significant risk for the whistle-blower. Objective To analyse the moral courage of potential whistle-blowers and its association with their background variables in health care. Research design Was a descriptive-correlational study using a questionnaire, containing Nurses Moral Courage Scale©, a video vignette of the wrongdoing situation with an open question about the vignette, and several background variables. Data were analysed statistically and inductive content analysis was used for the narratives. Participants and research context Nurses as healthcare professionals (including registered nurses, public health nurses, midwives, and nurse paramedics) were recruited from the membership register of the Nurses’ Association via email in 2019. A total of 454 nurses responded. The research context was simulated using a vignette. Ethical considerations Good scientific inquiry guidelines were followed. Permission to use the Nurses’ Moral Courage Scale© was obtained from the copyright holder. The ethical approval and permission to conduct the study were obtained from the participating university and the Nurses’ Association. Findings The mean value of potential whistle-blowers’ moral courage on a Visual Analogue Scale (0–10) was 8.55 and the mean score was 4.34 on a 5-point Likert scale. Potential whistle-blowers’ moral courage was associated with their socio-demographics, education, work, personality and social responsibility related background variables. Discussion and conclusion In health care, potential whistle-blowers seem to be quite morally courageous actors. The results offer opportunities for developing interventions, practices and education to support and encourage healthcare professionals in their whistleblowing. Research is needed for developing a theoretical construction to eventually increase whistleblowing and decrease and prevent wrongdoing.
Improving quantification of anticholinergic burden using the Anticholinergic Effect on Cognition Scale – a healthcare improvement study in a geriatric ward setting
Authors: Balasundaram Bharathi , Ang Wendy Swee Tee , Stewart Robert , Bishara Delia , Ooi Chun How , Li Fuyin , Akram Farooq , Eu Kwek Andrew Boon 
Published: June 2022

Objective Anticholinergic burden refers to the cumulative effects of taking multiple medications with anticholinergic effects. This study was carried out in a public hospital in Singapore, aimed to improve and achieve a 100% comprehensive identification and review of measured, anticholinergic burden in a geriatric psychiatry liaison service to geriatric wards. We evaluated changes in pre-to post-assessment anticholinergic burden scores and trainee feedback. Method Plan Do Study Act methodology was employed, and Anticholinergic Effect on Cognition scale (AEC) was implemented as the study intervention. A survey instrument evaluated trainee feedback. Results There was no measured anticholinergic burden in a baseline of 170 assessments. 75 liaison psychiatry assessments were conducted between June and November 2021 in two cycles. 94.7% of pre-assessments (at the time of assessment) and 71.1% of post-assessments (following assessment) had a record of AEC scores in clinical documentation in cycle one, improving in the second cycle to 100%, 94.6%, respectively. A high post-assessment AEC score of 3 and over reduced from 15.8% in cycle one to 5.4% in cycle two. The trainee feedback suggested an enriching educational experience. Conclusions Using the AEC scale, the findings support the feasibility of comprehensive identification and review of measured anticholinergic burden in older people with neurocognitive disorders.
Patients’ Perspectives on Coming Off Opioid Agonist Treatment: A Qualitative Study
Authors: Nehlin Christina , Bäckström Josefin , Brander Charlotte Wollert , Öster Caisa 
Published: June 2022

Aims: Opioid agonist treatment (OAT) programs are life-saving, as they reduce opioid use, overdoses, and criminal activities. Disadvantages reported with long-term OAT include side effects of the medication, especially on cognitive ability and sexual function, which may discourage potential participants. Many of those who participate in OAT have a desire to come off treatment. The aims of this study were to explore patients’ thoughts about coming off OAT and to investigate their perceptions of what support they would need in order to realize a planned withdrawal from OAT. Methods: A qualitative interview study with semi-structured interviews, using applied thematic analysis. Persons with experiences of participating in OAT were invited from Swedish programs and a private Facebook community. Results: Fifteen persons, with a mean of 9.6 (±6.4) years of treatment experience, were included. The participants underlined the need for a patient-centered focus within the treatment. They wanted to be regarded as capable of deciding if, when, and how a planned ending was to take place. They also called for staff to be supportive in making such decisions. Participants recommended staff to be sensitive to the needs of the specific patient and to have strategies for coming off OAT that could be adjusted for the single person. Conclusions: OAT programs need to be continually updated and adapted to the persons who can benefit from them. Applying a person-centered, holistic perspective would enhance the quality of the treatment by emanating from individual goals. Regulatory guidelines need to take into account research on patient experiences and perspectives on coming off.
A Nomogram to Predict Critical Weight Loss in Patients with Nasopharyngeal Carcinoma During (Chemo) Radiotherapy
Authors: Huang Chen , Chen Hongxiu , Zhang Xiaoxia , Zhang Qin , Liu Juan , Yu Huaqin , He Yinbo , Liu Zhe 
Published: June 2022

Background: Weight loss is an important side effect of long-term anticancer treatment for nasopharyngeal carcinoma patients. The decline in body function will cause many adverse effects, such as local recurrence and distant metastasis, and reduce the patient’s quality of life. Therefore, this study developed a predictive model for the probability of critical weight loss to provide timely appropriate nutritional interventions and prevent serious side effects. Methods: A 20-week prospective follow-up study of 137 nasopharyngeal carcinoma patients in West China Hospital of Sichuan University undergoing radiotherapy and chemotherapy from February 2018 to March 2020 was conducted to collect relevant clinical data. The clinical usefulness and calibration of the prediction model were assessed using the C-index, calibration plot, receiver operating curve, and decision curve analysis. Internal validation was assessed using bootstrapping validation. Results: The nomogram consisted of sex, smoking status, physical status, chemotherapy regimen, and body mass index. Good calibration was observed for the cohort, with an area under the curve of 0.924. Five independent prognostic factors were included in the nomogram, which showed a high C-index value of 0.815 in the interval validation. Decision curve analysis showed that the nomogram was clinically useful when the intervention was decided at the critical weight loss possibility threshold in the 0% to 97% range. Conclusions: We constructed and validated a nomogram for predicting the incidence of critical weight loss in nasopharyngeal cancer patients undergoing chemotherapy and radiotherapy.
Diagnostic Ability of Volatile Organic Compounds in Digestive Cancer: A Systematic Review With Meta-Analysis
Authors: Yang Hang , Mou Yi , Hu Bing 
Published: June 2022

Background: Volatile organic compounds (VOCs) have been involved in cancer diagnosis via breath, urine, and feces. We aimed to assess the diagnostic ability of VOCs on digestive cancers. Methods: We systematically reviewed prospective clinical trials evaluating VOCs’ diagnostic ability on esophageal, gastric, colorectal, hepatic, and pancreatic cancer (PC). Databases including PubMed and Ovid-Medline were searched. Results: A total of 35 trials with 5314 patient-times qualified for inclusion. The pooled sensitivity of VOCs diagnosing gastroesophageal cancer from healthy controls is 0.89 (95% confidence interval [CI]: 0.82-0.94), the pooled specificity is 0.890 (95% CI: 0.84-0.93), and area under the curve (AUC) of the summary receiver operating characteristic curve is 0.95 (95% CI: 0.93-0.95). The pooled sensitivity of VOCs diagnosing colorectal cancer from heathy controls is 0.92 (95% CI: 0.85-0.96), the pooled specificity is 0.88 (95% CI: 0.77-0.94), and the AUC is 0.96 (95% CI: 0.94-0.97). The pooled sensitivity of VOCs distinguishing gastrointestinal (GI) cancer from precancerous lesions is 0.84 (95% CI: 0.67-0.92), the pooled specificity is 0.74 (95% CI: 0.43-0.91), and the AUC is 0.87 (95% CI: 0.84-0.89). The pooled sensitivity of VOCs diagnosing hepatocellular carcinoma is 0.68 (95% CI: 0.52-0.81), the pooled specificity is 0.81 (95% CI: 0.47-0.96), and the AUC is 0.78 (95% CI: 0.74-0.81). The pooled sensitivity of VOCs diagnosing PC is 0.88 (95% CI: 0.80-0.93), the pooled specificity is 0.82 (95% CI: 0.62-0.93), and the AUC is 0.92 (95% CI: 0.89-0.94). Conclusions: Volatile organic compounds have potential role in diagnosing GI cancer with comparatively high sensitivity, specificity, and AUC (PROSPERO registration number: CRD42021260039).
Automatically identifying opioid use disorder in non-cancer patients on chronic opioid therapy
Authors: Zhu Vivienne J , Lenert Leslie A , Barth Kelly S , Simpson Kit N , Li Hong , Kopscik Michael , Brady Kathleen T 
Published: June 2022

Background: Using the International Classification of Diseases (ICD) codes alone to record opioid use disorder (OUD) may not completely document OUD in the electronic health record (EHR). We developed and evaluated natural language processing (NLP) approaches to identify OUD from the clinal note. We explored the concordance between ICD-coded and NLP-identified OUD. Methods: We studied EHRs from 13,654 (female: 8223; male: 5431) adult non-cancer patients who received chronic opioid therapy (COT) and had at least one clinical note between 2013 and 2018. Of eligible patients, we randomly selected 10,218 (75%) patients as the training set and the remaining 3436 patients (25%) as the test dataset for NLP approaches. Results: We generated 539 terms representing OUD mentions in clinical notes (e.g., “opioid use disorder,” “opioid abuse,” “opioid dependence,” “opioid overdose”) and 73 terms representing OUD medication treatments. By domain expert manual review for the test dataset, our NLP approach yielded high performance: 98.5% for precision, 100% for recall, and 99.2% for F-measure. The concordance of these NLP and ICD identified OUD was modest (Kappa = 0.63). Conclusions: Our NLP approach can accurately identify OUD patients from clinical notes. The combined use of ICD diagnostic code and NLP approach can improve OUD identification.