bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolasi Bakteri Pengakumulasi Poliposfat
Authors: Sudiana I Made 
Published: February 2022

Polyphosphate accumulating bacteria play important key role on biological phosphorous removal. Activated sludge originated from wastewater treatment plant for drinking water production acclimated with anaerobic-aerobic phase in sequential batch reactor continuously succeed to establish microbial community that are able to adsorb glucose and acetate under anaerobic condition. Acinetobacter calcoaceticus S1 was an isolated bacterium from community performing organic substrate absorption. S1 is able to adsorb glucose and acetate under anaerobic condition. During substrate absorption an increase of orthophosphate in bulk solution indicating phosphate released out of cell. Reduction of glycogen and polyhydroxybutirate (PHB) took place under anaerobic phase. S1 is a community member of anaerobic-aerobic system for removal of phosphorous in influent wastewater.
Advances in the research field of osteoporosis in cold areas
Authors: Zhou Ping , Zhang Hanlu , Nie Yizhen , Zhang Yimeng , Wang Yongchen 
Published: February 2022

Abstract
While osteoporosis is a chronic disease caused by multiple factors, it is also a risk factor for fractures. At present, numerous risk factors for osteoporosis and secondary fractures have been identified, including sunlight, physical fitness, gender, age, trauma, dietary habits, tobacco, alcohol, drugs, air quality, and genetics. Despite that factors such as long winters, short daylight hours, less daily physical activity, air pollution, low calcium and high salt diet, and sedentary lifestyle could negatively impact the bones of residents in the alpine regions of northern China, the direct effect of low-temperature stimulation on bone growth and development remains unclear. In this study, by reviewing current research progress related to osteoporosis and fracture risk in northern China, we proposed appropriate preventive measures for different risk factors to reduce the occurrence of osteoporosis and fracture in cold areas of northern China.
Ticagrelor versus clopidogrel in East Asian patients with acute coronary syndrome: A meta-analysis
Authors: He Meijiao , Zang Yanxiang , Sun Danghui , Li Jianqiang , Liu Guangzhong , Shi Jing , Li Yue 
Published: February 2022

Abstract

Objective
There exist conflicting data on the efficacy and safety of ticagrelor and clopidogrel in East Asian patients with acute coronary syndrome (ACS). We performed a meta-analysis to evaluate whether ticagrelor or clopidogrel produces better outcomes for East Asian patients with ACS.

Methods
We searched for randomized controlled trials reporting associations between ticagrelor and clopidogrel in East Asian patients with acute coronary syndrome in PubMed, EMBASE, web of science and Cochrane central register of controlled trials.

Results
Ten studies involving 3 715 participants were qualified for our analysis. The major adverse cardiovascular events (MACE) were significantly decreased in patients with ticagrelor treatment compared to those with clopidogrel (risk ratio [RR]: 0.61; 95% confidence interval [CI]: 0.38–0.98; P = 0.042). There was no significant difference in all-cause death (RR: 0.89; 95% CI: 0.61–1.29; P = 0.540), cardiovascular death (RR: 0.86; 95% CI: 0.58–1.27; P = 0.451), myocardial infarction (RR: 0.91; 95% CI: 0.65–1.27; P = 0.575) and stroke (RR: 0.77; 95% CI: 0.44–1.36; P = 0.372) between ticagrelor and clopidogrel. Ticagrelor was associated with a significantly higher risk of bleeding compared to clopidogrel (RR: 1.71; 95% CI: 1.37–2.13; P = 0.000).

Conclusion
The present meta-analysis demonstrates that ticagrelor reduced the incidence of MACE in ACS patients from East Asia compared with clopidogrel. However, it increased the risk of bleeding.
Study of the incidence of hyperuricemia in young males’ population with rapid entry into the plateau of 4 500m
Authors: Liu Chang'e , Liu Yingyue , Hong Xiaoyang , Feng Zhichun 
Published: February 2022

Abstract

Objective
To study the incidence and risk factors of hyperuricemia in young males who rapid entered into the plateau of 4 500 m.

Methods
The study contained 390 males aged 18–35 years (21.6 ± 2.5 years), who rapidly entered the plateau with an altitude of 4 500 m. According to their basic level of uric acid (UA), they were divided into two groups, high uric acid (HUA) group and normal uric acid (NUA) group. The characteristics and physiological index, such as the body weight and the height, of them were recorded. For the test of the biochemical indicators, the venous blood samples were collected at the altitude of 4 500 m in the morning. The count of blood cells, blood urea nitrogen (BUN), serum creatinine (SCR), lactate dehydrogenase (LDH), total bilirubin (TBIL), direct bilirubin (DBIL) and indirect bilirubin (IDBIL) were compared between the two groups.

Results
The incidence of hyperuricemia was 65.1% (254/390) at 4 500 m. At the altitude of 4 500 m, the mean hemoglobin concentration (MCHC) of red blood cells in the HUA group was significantly lower than that in the NUA group. Hemoglobin (HGB), mean red blood cell volume (MCV), TBIL, IDBIL, BUN, SCR and LDH in the HUA group were significantly higher than those in the NUA group, though without statistically significant differences in the other variables. Meanwhile, multivariate analysis showed at the altitude of 4 500 m, the risk of HUA increased by 0.982, 1.038 and 1.045 times when MCHC decreased by one unit and TBIL and SCR increased by one unit, respectively.

Conclusion
The incidence of hyperuricemia was high of 65.1% rush entry into the plateau of young male. Decreased MCHC and elevated TBIL and SCR were independent risk factors for hyperuricemia when rapid enter into 4 500 m.
Penerapan Bentuk Geometris Pada Perancangan Interior Lounge & Bar Manhattan Hotel Jakarta
Authors: Catherine Angelica , Supriyatna Eddy , Florencia Maria 
Published: February 2022

Manhattan Hotel menyediakan lounge & bar untuk memenuhi aktivitas dengan kemajuan industri dan ekonomi ibu kota yang pesat. Perancangan hotel perlu mendapat sentuhan desain interior agar dapat menampilkan citra dari sebuah hotel. Lounge & bar Manhattan Hotel dirancang dengan tujuan menampikan kesan modern dan formal karena merupakan pilihan bagi para pengunjung dimana pertumbuhan Jakarta semakin berkembang sehingga menghasilkan gaya hidup baru, sehingga diperlukan tempat yang mewadahi kegiatan bisnis dilingkup ruang sosial khususnya untuk para eksekutif muda menengah ke atas. Metode perancangan ini menggunakan metode kualitatif yaitu pelaksanaan yang menghasilkan data deskriptif berupa kata-kata tertulis maupun lisan dari orang-orang dan perilaku yang diamati. Pada perancangan ini, hasil citra dan suasana yang diciptakan adalah elegan, modern, dan contemporer. Gaya modern menjadi pilihan yang cocok dengan lifestyle masyarakat Jakarta saat ini. Kesimpulannya ialah elemen interior lantai lounge& bar yang didesain ini harus mempertimbangkan segala aspeknya, karena sangat berpengaruh terhadap pemenuhan kebutuhan aktivitas, perilaku, dan latar belakang pengunjung agar nyaman disana. Namun yang diperhatikan tidak hanya dari segi fungsi tetapi estetika juga diperlukan.Kata kunci— Bar; Hotel; Interior; Lounge; Manhattan
Susceptibility to thiopurine toxicity by TPMT and NUDT15 variants in Colombian children with acute lymphoblastic leukemia
Authors: Correa-Jimenez Oscar , Yunis Juan José , Linares-Ballesteros Adriana , Sarmiento-Urbina Isabel 
Published: February 2022

Objective:
This study aimed to correlate the genetic profile of the NUDT15 and TPMT genes with the side effects of the treatment of pediatric patients with acute lymphoid leukemia who were undergoing maintenance therapy at a tertiary care hospital in 2017.

Methods:
This was an analytical, longitudinal, observational study in which the genotypes of the genes of interest were determined by PCR allelic discrimination with TaqMan® probes in patients receiving chemotherapy during the maintenance phase in the Pediatric Hematology and Oncology Unit in 2017. Sociodemographic and clinical data corresponding to the first six months of their maintenance chemotherapy were collected, and the correlation between the genotypes obtained and the development of side effects during the maintenance phase of chemotherapy in these patients was evaluated.

Results:
Seventy pediatric patients were included in the study. Genetic analyses were carried out of these for NUDT15 and TPMT (rs1800462 and rs1800460) on 68 patients, while for the rs1142345 polymorphism, typing was achieved in 42 patients. 4/68 patients were heterozygous for NUDT15, and the same number of patients were heterozygous for rs1800462 and rs1142345, while for rs1800460, 6 heterozygous patients were identified. No statistically significant association was identified between the genetic variants and the outcomes of interest.

Conclusion:
Studies with a larger population size are needed and the evaluation of other genetic variants that may influence the development of side effects during maintenance chemotherapy.
Nuevas modalidades de financiación para combatir la pobreza en Colombia
Authors: Jiménez Sánchez Jorge Iván 
Published: February 2022

Resumen
La pandemia de Covid-19 ha incrementado la pobreza en Colombia, el país retrocederá años de avances en esta materia, para salir adelante se requiere tener una financiación adecuada lo cual es bastante difícil. Los bancos tradicionales son reacios a prestar a los más necesitados, debido a los bajos montos a los que pueden acceder, la falta de garantías y colaterales, así como el alto costo que representan para las entidades, todo esto los hace clientes no aptos para el sistema financiero tradicional. Esto obliga a muchos a buscar otras formas de financiación que a menudo son inadecuadas. Para afrontar el problema existen varias alternativas, muchas de ellas de particulares debidamente autorizados que pueden prestar servicios financieros en mejores condiciones. La búsqueda concluye que es posible encontrar mejores modalidades de financiación, que pueden ayudar a combatir la pobreza.
Comparison of antimicrobial effect of selenium nanoparticles and silver nanoparticles coated orthodontic mini-implants – An in vitro study
Authors: Subramanian Saravana Kumar , Anbarasu Prema , Navin N. , Iyer Sushmita R. 
Published: February 2022

Objectives:
Mini-implants have earned a significant role in orthodontic treatment, by augmenting anchorage requirements. Peri-implantitis contributes to miniscrew failures where progressive peri-implant bone loss occurs in conjunction with soft-tissue inflammation due to the growth of microorganisms such as Streptococcus and Lactobacillus. Nanoparticles have increased surface area and have increased interactions with biological targets like bacteria. This study aims to investigate the antimicrobial activity of silver nanoparticles (AgNP) and selenium nanoparticles (SeNPs) on orthodontic mini-implants.

Material and Methods:
Mini-implant (Ti-6Al-4V) was coated with AgNP and SeNP with biopolymer (Ti-BPAgNP and Ti-BPSeNP) by dip-coating technique. The crystal structure and crystallite size of AgNPs and SeNPs were characterized by the X-ray diffraction (XRD) method. The size distribution and morphology of SeNP and AgNP were determined by a scanning electron microscope (SEM). The antibacterial activity of Ti-BP-AgNP and Ti-BPSeNP was detected from the zone of inhibition by disk diffusion assay.

Results:
The SEM image of AgNP was roughly spherical, uniformly distributed and SeNPs were spherical, well distributed on the biopolymer surface. The area of the zone of inhibition of Ti-BP-SeNP-coated mini-implants shows a negligible difference in antibacterial activity compared to Ti-BPAgNP-coated mini-implants.

Conclusion:
Ti-BP-AgNP and Ti-BP-SeNP showed that a strong antibacterial activity was against Lactobacillus and Staphylococcus aureus. Antibacterial activity against Streptococcus mutans was slightly less than observed in other bacteria. SeNP shows only a marginal difference in antibacterial activity when compared to AgNP.
Intramedullary abscess at thoracolumbar region transmitted from infected dermal sinus and dermoid through retained medullary cord
Authors: Matsubara Yoshie , Murakami Nobuya , Kurogi Ai , Lee Sooyoung , Mukae Nobutaka , Shimogawa Takafumi , Shono Tadahisa , Suzuki Satoshi O. , Yoshimoto Koji , Morioka Takato 
Published: February 2022

Background:
A retained medullary cord (RMC) is a relatively newly defined entity of closed spinal dysraphism that is thought to originate from regression failure of the medullary cord during secondary neurulation. A congenital dermal sinus (CDS) may provide a pathway for intraspinal infections such as repeated meningitis. Intramedullary abscesses are the rarest but most serious complication of a CDS.

Case Description:
We treated a female infant with an intramedullary abscess in the thoracolumbar region, which was caused by infection of the CDS. Surgery revealed that the cord-like structure (C-LS) started from the cord with the intramedullary abscess, extended to the dural cul-de-sac, and further continued to the CDS tract and skin dimple. The boundary between the functional cord and the non-functional CL-S was electrophysiologically identified, and the entire length of the C-LS (the RMC) with an infected dermoid cyst was resected. As a result, the abscess cavity was opened and thorough irrigation and drainage of the pus could be performed. Histopathological examination of the C-LS revealed an infected dermoid cyst and abscess cavity with keratin debris in the fibrocollagenous tissue. The abscess cavity had a central canal-like ependymal lined lumen (CCLELL), with surrounding glial fibrillary acidic protein (GFAP)-immunopositive neuroglial tissues.

Conclusion:
We demonstrated that the transmission of an infection through the RMC was involved in the development of the intramedullary abscess. A good postoperative outcome was obtained because a terminal ventriculostomy for pus drainage could be achieved by excising the nonfunctional RMC.
Surgical management of a thoracic chordoma: A case report and literature review
Authors: Moune Michèle Yolande , Sayore Christine Milena , Hemama Mustapha , El Fatemi Nizare , El Maaqili Moulay-Rachid 
Published: February 2022

Background:
Chordomas are rare benign, but locally aggressive tumors that are regularly encountered in the clivus and sacrum. Although they are rarely found in the thoracic spine, they can contribute not only to local bone destruction and spinal instability, lead to cord compression, and major neurological deficits.

Case Description:
A 56 year-old-male originally underwent a T12 laminectomy with debulking for a thoracic chordoma. Two years later, the lesion recurred contributing to a significant paraparesis. The new MR showed a T2 hyper intense lesion with huge epidural extension that warranted a 360° surgical decompression and fusion. The histopathology from both surgeries confirmed the diagnosis of a chordoma.

Conclusion:
Combined 360° decompression and fusion was warranted to resect a T12 chordoma that recurred 2 years following an original laminectomy with debulking procedure.
Sporadic desmoid fibromatosis of the neck after dorsal spondylodesis of the cervical spine
Authors: Schlag Holger , Neuhoff Jonathan , Castein Jens , Hoffmann Chirstoph , Kandziora Frank 
Published: February 2022

Background:
Rare soft-tissue tumors, termed desmoid fibromatosis (DF), are comprised proliferated spindle cell fibroblasts and myofibroblasts embedded in a prominent collagenous stroma. They can occur either sporadically, due to prior trauma or surgery, or may have a genetic component. Clinically, DF has a high infiltrative growth/ local recurrence rate, but does not metastasize.

Case Description:
A 58-year-old male underwent a C5-C7 laminectomy/instrumented fusion. Two years later, he presented with a large gross swelling on the right side of the neck. The lesion was removed and proved to histologically consist of DF. Within the first postoperative 12 months, tumor did not recur.

Conclusion:
Sporadic DF may follow trauma or prior surgery. Symptomatic tumors are treated by surgical en bloc resection (preferably R0). If lesions are inoperable, partially resected, or recur, different hormonal/ chemotherapeutic systematic treatment options are available (e.g., tamoxifen or tyrosine kinase inhibitors). In the future, better molecular understanding of DF likely offers additional therapeutic approaches (e.g., immune checkpoint inhibitors).
Leptomeningeal dissemination of a malignant melanotic nerve sheath tumor: A case report and review of the literature
Authors: Shui Cher , Davey Louella , Scholsem Martin 
Published: February 2022

Background:
Malignant melanotic nerve sheath tumors (MMNSTs) are rare tumors of presumed neural crest origin. Here, we present a 21-year-old female with a left L5/S1 MMNST along with a review of approximately 70 spinal cases reported in the literature, the majority of which were either local recurrences or metastases.

Case Description:
A 21-year-old female presented with 3 months of severe left L5 distribution radicular leg pain and sensory loss. The MR revealed a dumbbell-shaped, heterogenously enhancing lesion centered on the left L5/S1 foramen; the intracanalicular component displaced the thecal sac to the right, while the extraforaminal portion of tumor extended anteriorly into the retroperitoneal space. Gross total resection was performed after a L5/S1 facetectomy. In the immediate postoperative period there were no complications, and the patient had full lower limb power. Four months later, the patient experienced generalized seizures, headache, and multiple cranial nerve palsies due to local and diffuse CNS dissemination. The MRI of the brain and whole spine revealed diffuse leptomeningeal enhancement along the full length of the spinal cord into the brainstem and cerebrum along with a focally recurrent epidural soft-tissue lesion located posterolaterally on the left at the L4/5 level (i.e., measuring 12 mm × 10 mm). An external ventricular drain and subsequent ventriculoperitoneal shunt were inserted, followed by craniospinal irradiation. She was discharged 3 months later with residual distal lower limb weakness.

Conclusion:
This case illustrates the rapid disease progression of MMNST despite gross total resection. Further such lesions should be aggressively treated locally, and followed by adjuvant radiotherapy and systemic chemotherapy/immunotherapy.
Resection arthroplasty for isolated costotransverse joint osteoarthritis: A case report and literature review
Authors: Pontes Julia Pereira Muniz , Ferreira-Pinto Pedro Henrique Costa , da Costa Louise Ferreira Nascimento Pestana , Martha Bernardo Martins Rodrigues , da Silva Wellerson Novaes , Senior Maria Eduarda Freire Lopes , Ferreira Tadeu Diniz , Simoes Elington Lannes , Nigri Flavio 
Published: February 2022

Background:
Symptomatic isolated costovertebral joint (CVJ) osteoarthritis is rare, and establishing this diagnosis is often difficult. There are few reports in the literature about how to surgically manage these lesions. Our aim was to describe a case of isolated osteoarthritis of the costotransverse joint (CTJ) successfully treated with a resection arthroplasty.

Case Description:
A 51-year-old female presented with 3 years of the right paravertebral T 10-level back and radiating pain. No conservative treatment modality effectively resolved this pain (i.e., these included anti-inflammatory medications, physiotherapy, and joint blockages). MRI, CT, and technetium-99m methylene diphosphonate bone scintigraphy demonstrated inflammatory changes involving the right T10 CTJ. Following resection arthroplasty, the patient’s symptoms abated.

Conclusion:
Symptomatic osteoarthritis of the right T10 CVJ successfully resolved following costotransversectomy for joint resection arthroplasty.
PENGARUH RELIGIUSITAS MAHASISWA UNIVERSITAS ISLAM RIAU TERHADAP KEPUTUSAN MENABUNG DI BANK SYARIAH
Authors: Mufti Hasan Alfani  , Rifa  
Published: February 2022

Penelitian ini keputusan menabung di Bank Syariah yang dipengaruhi religiusitas mahasiswa Universitas Islam Riau. Salah satunya dapat dilihat dari pengetahuan dan keyakinan tentang Bank Syariah. Banyak yang mengartikan bahwa konsep Bank Syariah dengan Bank Konvensional sama. Padahal hal tersebut merupakan dua hal yang berbeda. Tujuan penelitian ini adalah untuk mengetahui pengaruh religiusitas mahasiswa terhadap keputusan menabung di Bank Syariah. Penelitian ini menggunakan pendekatan deskriptif kuantitatif, dengan jumlah sampel 267 responden. Data yang digunakan dalam penelitian ini adalah data primer dan data sekunder. Data primer diperoleh dari kuesioner yang dibagikan kepada responden. Sedangkan, data sekunder diperoleh dari jurnal, buku-buku yang berkaitan dengan judul penelitian ini. Serta, teknik analisis data yang digunakan dalam penelitian ini adalah analisis regresi linier sederhana dengan menggunakan uji T (Parsial) dan uji Koefisien Determinasi (R2). Hasil penelitian menunjukkan terdapat pengaruh signifikan terhadap keputusan menabung di Bank Syariah. Dengan memperoleh hasil T-hitung (15,66) > T-tabel (1,97), dan nilai signifikansi sebesar 0,000 < 0,05. Serta dapat diartikan bahwa terdapat pengaruh signifikan variabel religiusitas (X) terhadap keputusan menabung (Y) secara parsial. Sedangkan, hasil uji koefisien determinasi menunjukkan sebesar 48,1%. Ini berarti bahwa religiusitas mempengaruhi keputusan menabung di Bank Syariah sebesar 48,1%.
Mathematical modeling of toroidal source signals in three-dimensional isotropic earth models
Authors: Суродина И.В. , Михайлов И.В. , Глинских В.Н. 
Published: February 2022

В работе рассматривается математическое моделирование электромагнитных откликов тороидального источника в несимметричных изотропных средах, выполненное с помощью конечно-разностного метода. Описывается постановка задачи, методы решения. Анализируются результаты численного моделирования для нового типа источника в области промысловой геофизики.
The paper considers the finite-difference mathematical modeling of electromagnetic responses from a toroidal source in asymmetric isotropic media. We state the problem and solution methods. The results of numerical simulation for the new source type in the field of petroleum geophysics are analyzed.
RESEARCH AND ASSESSMENT OF THE STATE OF PLANTS IN ARTIFICIAL PLANT COMMUNITIES (ON THE EXAMPLE OF THE VOLGA AND CHERNOZEM REGIONS)
Authors: Ларионов М.В. , Ларионов Н.В. , Володькин А.А. , Догадина М.А. 
Published: February 2022

Приведены результаты исследований потенциала приспособленности, жизнеспособности и уровней поврежденности кустарников и деревьев в поселениях Поволжья и Черноземья. Среднестатистические значения установленных биологических параметров этих растений характеризуют показатели состояния и биологической устойчивости образованных на их основе растительных сообществ на рассмотренных территориях. Они также отражают их экологические и хозяйственные признаки. Полученные данные о жизненности растений имеют и комплексное биоиндикационное значение.
The results of studies of the potential of adaptability, viability and levels of damage to shrubs and trees in the settlements of the Volga and Chernozem regions are presented. The average statistical values ​​of the established biological parameters of these plants characterize the indicators of the state and biological stability of the plant communities formed on their basis in the territories under consideration. They also reflect their ecological and economic characteristics. The obtained data on the vitality of plants also have a complex bioindication value.