bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality evaluation and life expectancy prediction of patients with Hepatocellular carcinoma with data minding
Authors: Liu Che-Yu , Cheng Chen-Yang , Yang Szu-Ying , Chai Jyh-Wen , Chen Wei-Hao , Chang Pi-Yi 
Published: November 2022

Abstract
Background: The complexity of systemic variables and comorbidities make it difficult to determine the best treatment for patients with hepatocellular carcinoma (HCC). It is impossible to perform a multidimensional evaluation of every patient, but guidelines based on analyses of said complexities would be the next best option. Traditional statistics are inadequate for developing predictive models with many variables; however, data mining is well-suited to the task.
Patients and Methods and finding: The clinical profiles and data of a total of 537 patients diagnosed with Barcelona Clinic Liver Cancer stages B and C from 2009 to 2019 were retrospectively analyzed using 4 decision-tree algorithms. 19 treatments, 7 biomarkers, and 4 states of hepatitis were tested to see which combinations would result in survival times greater than a year. 2 of the algorithms produced complete models through single trees, which made only them suitable for clinical judgement. A combination of alpha fetoprotein ≤ 210.5 mcg/L, glutamic oxaloacetic transaminase ≤ 1.13 µkat/L, and total bilirubin ≤ 0.0283 mmol/L was shown to be a good predictor of survival > 1 year, and the most effective treatments for such patients were radio-frequency ablation (RFA) and transarterial chemoembolization (TACE) with radiation therapy (RT). In patients without this combination, the best treatments were RFA, TACE with RT and targeted drug therapy, and TACE with targeted drug therapy and immunotherapy. The main limitation of this study was small sample. With small sample size, we may developed a less reliable model system, failing to produce any clinically important results or outcomes
Conclusion: Data mining can produce models to help clinicians predict survival time at the time of initial HCC diagnosis and then choose the most suitable treatment.
Aβ plaque deposition and microgliosis following Aβ seeding in AppNL-G-F mice is regionally distinct
Authors: Lacoursiere Sean G. , Mohajerani Majid H. , Sutherland Robert J. 
Published: November 2022

Abstract
Background.
Alzheimer’s disease (AD) is characterized by the prion-like propagation of amyloid-β (Aβ). However, the role of Ab in cognitive impairment is still unclear.
Methods.
Two-month-old AppNL-G-F were intracerebrally seeded with three conformationally distinct Aβ seeds. The mice were trained in a multi-model paradigm using multiple behavioural tests. Immunohistochemical techniques were used to assess Ab deposition, microgliosis, and cholinergic tone.
Results.
Seeding accelerated AD pathology throughout the brain in a region-dependent manner. Microgliosis was elevated in the substantia nigra reticular area. The cholinergic tone was found to be significantly reduced in the medial septal band. No impairment in learning and memory was found.
Conclusion.
These results suggest seeding accelerates microglial and Ab plaque progression in a regional distinct manner with the seed having no unique effect on behaviour or histological markers.
Gels: Energetics, Singularities and Cavitation
Authors: Calderer Maria-Carme , Henao Duvan , Sanchez Manuel , Siegel Ronald A. , Song Sichen 
Published: November 2022

Abstract
This article studies equilibrium singular configurations of gels and addresses open questions concerning gel energetics. We model a gel as an incompressible, immiscible and saturated mixture of a solid polymer and a solvent that sustain chemical interactions at the molecular level. We assume that the energy of the gel consists of the elastic energy of its polymer network plus the Flory-Huggins energy of mixing. The latter involves the entropic energies of the individual components plus that of interaction between polymer and solvent, with the temperature dependent Flory parameter, chi, encoding properties of the solvent. In particular, a good solvent promoting the mixing regime, is found below the threshold value chi=0.5, whereas the phase separating regime develops above that critical value. We show that cavities and singularities develop in the latter regime. We find two main classes of singularities: (i) drying out of the solvent, with water possibly exiting the gel domain through the boundary, leaving behind a core of exposed polymer at the centre of the gel; (ii) cavitation, in response to traction on the boundary or some form of negative pressure, with a cavity that can be either void or flooded by the solvent. The straightforward and unified mathematical approach to threat all such singularities is based on the construction of appropriate test functions, inspired by the particular states of uniform swelling or compression. The last topic of the article addresses a statistical mechanics rooted controversy in the research community, providing an experimental and analytic study in support of the phantom elastic energy versus the affine one.
Mathematics Subject Classification (2020) 35B40 · MSC 35J57 · 74B20 · 74G65 · 74R99
Evaluation of bone area in the posterior region for mandibular molar distalization in Class I and Class III patients
Authors: Özden Samet , Uslu Filiz , Dedeoğlu Numan 
Published: November 2022

Abstract
Objectives
The aim of this study was to investigate the bone area in the posterior region, which is important for mandibular molar distalization in skeletal Class I and Class III individuals with normodivergent and hyperdivergent vertical growth patterns.
Materials and Methods
In this study, cone-beam computed tomography scans of 120 individuals divided into 4 groups as Class I normodivergent (Group-I), Class I hyperdivergent (Group-II), Class III normodivergent (Group-III) and Class III hyperdivergent (Group-IV). Retromolar space at crown level measurements were performed on CBCT-derived panoramic radiographs and axial sections. Retromolar space at the root level was measured 2mm, 4mm, 6mm, 8mm and 10mm apical to cemento-enamel junction at CBCT axial sections.
Results
Retromolar space decreased towards the root apex in all groups and smallest retromolar space was level of CEJ10mm in all groups. At any root level, the distal root of the mandibular second molar tooth was in contact with the mandibular inner or outer lingual cortex; 50% in Group-I, 46.7% in Group-II, 7% in Group-III and 7% in Group-IV.
Conclusions
In normodivergent individuals, the retromolar area length at the root level is observed to be higher in Class III than in Class I at almost every level. In hyperdivergent individuals, on the other hand, only at CEJ10 level, it is higher in length in Class III than in Class I. Vertical growth pattern has no effect on the root and crown level retromolar space in Class I and Class III individuals.
Clinical Relevance
CBCT provides more useful information than panoramic radiographs for patients who are scheduled for large mandibular molar distalization
Pistacia atlantica (Bene) Oleoresin Gum: The Antioxidant and Antimicrobial Activity, and Potential Encapsulation of Saccharomyces boulardii and Lactobacillus acidophilus in Kefir with Sodium Alginate/Bene Gum Polymer
Authors: Khoramdareh Niloufar Bakhshi , Hamedi Hassan , Sharifan Anousheh 
Published: November 2022

Abstract
One of the main products obtained from the Pistacia atlantica (Bene) tree, in addition to the fruit, is oleoresin gum which is rich in polysaccharides and polyphenolic compounds. This study was conducted to evaluate the antioxidant and antimicrobial activity of Bene gum and its potential application with alginate in probiotic microencapsulation. Chemical analysis showed that the most abundant monosaccharides in Bene gum were arabinose, galactose, and galacturonic acid, and the most representative volatile compound was α-pinene. Bene extract was rich in phenolic compounds and showed good antioxidant activity. The results showed that the gum was effective against all bacteria tested at a concentration of 50 µg/ml and Gram-negative bacteria showed higher resistance than Gram-positive bacteria. Encapsulation of Saccharomyces boulardii and Lactobacillus acidophilus with sodium alginate and Bene gum biopolymers gave an encapsulation yield of 80%. The survival rate of encapsulated probiotics compared to the free form was significantly increased after exposure to simulated gastrointestinal conditions. The viability results of probiotics in kefir were very similar to results obtained from simulated gastrointestinal conditions, while the encapsulated form of probiotics in kefir showed a consistent increase in viability over 28 days of storage. Overall, products encapsulated with a high percentage of gum showed better taste acceptance than uncoated and alginate-coated samples. Likewise, samples containing microencapsulated probiotics also generally had good overall acceptability. Based on these results, it can be concluded that Bene gum is an excellent candidate for the preparation of various biocomposites and nanoparticles.
Cortical thickness relates to working memory performance after non-invasive brain stimulation
Authors: Razza Lais , Vanderhasselt Marie-Anne , Luethi Mattias , Rapple Jonathan , Busatto Geraldo , Buchpiguel Carlos , Brunoni Andre , Silva Pedro Rodrigues da 
Published: November 2022

Abstract
Objective
We investigated whether baseline cortical brain thickness of regions of interest (ROIs) was associated with working memory (WM) performance after non-invasive brain stimulation (NIBS) probing the dorsolateral prefrontal cortex (DLPFC).
Method
Structural Magnetic Resonance Imaging data were analyzed from 22 healthy subjects who received transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS) and placebo. Bifrontal tDCS was placed over the neuronavigated left and right DLPFC (20 minutes/2mA). iTBS targeted the neuronavigated left DLPFC applying 1620 pulses. A 2-back task was conducted after the end of NIBS sessions. Selected ROIs were the bilateral DLPFC, medial PFC and posterior cingulate cortex (PCC).
Results
Findings revealed an inverse association between cortical thickness of the DLPFC and reaction time for both tDCS (left: p = 0.02; right: p = 0.007) and iTBS (left: p = 0.02) compared to placebo. Moreover, thickness of the right mPFC and the left PCC were inversely and directly associated with reaction time after iTBS, respectively (p = 0.046 and p = 0.03). No association was found for accuracy.
Conclusion
Our findings provide the first evidence that individual cortical thickness of healthy subjects might be associated with WM performance.
Validation of the French version of the THYCA-QoL questionnaire for the health-related quality of life in thyroid cancer patients.
Authors: Scheller Boris , Santini Joseph , Culie Dorian , Contu Sara , Anota Amélie , Chateau Yann , Schiappa Renaud , Dassonville Olivier , Poissonnet Gilles , Seferiadis Anastasia , Bozec Alexandre , Chamorey Emmanuel 
Published: November 2022

Abstract
Background: Health-related quality of life (HRQoL) is an important outcome in oncology. In our previous work, the specific questionnaire to evaluate the HRQoL for thyroid cancer, the THYCA-QoL, has been translated into French. In this work we aimed to validate the psychometric properties of the French version of the THYCA-QoL questionnaire (F-THYCA-QoL).
Methods: The F-THYCA-QoL is composed of 24 items and is divided into 7 dimensions and 6 single items. The F-THYCA-QoL and QLQ-C30 of the European Organisation for Research and Treatment of Cancer (EORTC) were mailed to thyroid cancer patients undergoing surgery. Data from responders obtained was used to test acceptability, reliability and validity of the F-THYCA-QoL questionnaire.
Results: Among contacted patients, 280 patients of the University Institute of Face and Neck of Nice responded to the questionnaire between January 2015 and January 2019. The low number of missing data (0.007%) showed a good acceptability of the questionnaire. Six of the 7 items exhibited a good internal consistency with a Cronbach’s alpha ≥ 0.70. No floor or ceiling effects were observed. Factorial validity was demonstrated for 5 scales out of 7, using a multitrait-multimethod analysis and an exploratory factor analysis. Criterion validity assessed between the F-THYCA-QoL and QLQ-C30 was satisfactory.
Conclusion: The F-THYCA-QoL questionnaire is a reliable and valid assessment tool that used with the EORTC QLQ-C30 allows to evaluate the HRQoL of thyroid cancer patient in France.
Symbiotic efficiency, rhizosphere competence and nodule occupancy of chickpea root-nodule bacteria from Australian soils
Authors: Oparah Irene Adu , Deaker Rosalind , Hartley Jade Christopher , Sohail Muhammad , Gemell Lance Greg , Hartely Elizabeth , Kaiser Bren Noraman 
Published: November 2022

Abstract
Aims: To evaluate the suitability of novel chickpea rhizobia for use as commercial chickpea inoculants
Methods: Root nodule bacterial isolates from field grown chickpea were evaluated in glasshouse and field experiments based on infectivity, relative symbiotic effectiveness nodule occupancy ability and survivability in the soil rhizosphere.
Results: Compared to the Australian commercial chickpea inoculant strain Mesorhizobium ciceri sv. ciceri CC1192, the 10 novel strains were fast growers, taking ~ 72 hours to grow at 23oC. The strains showed high degree of infectivity and effectiveness both in the glasshouse and field. Relative symbiotic effectiveness (RSE%) of the novel strains in glasshouse experiments determined by shoot weight ranged from 77-111% in Desi genotype (Kyabra) and 83-102% in Kabuli (Kimberley Large). None of the novel strains differed from CC1192 in total shoot N content. Except for strain 3/4 and M. ciceri sv. ciceri CC1192, the RP01 RAPD fingerprint profiles of the strains were variable and diversity among strains did not correlate to their source of origin. A phylogenetic comparison of the cloned 16S rRNA sequences identified M. ciceri LMG 14989 as the most common distant relative to all strains. Also, the strains were able to survive in soil rhizosphere, had a higher competitive ability and were able to compete with background rhizobia population for nodule occupancy.
Conclusions: There are several rhizobial strains in naturalised soil populations that may be better adapted to local soil conditions which would confer an advantage for survival and competition for nodulation.
Efficient mutation induction using carbon-ion beams irradiation and simple genomic screening with SSR and RAPD in japonica rice
Authors: Wang Jiaqi , Yang Fu , Li Jingpeng , Zhou Libin , Du Yan , Yu Lixia , Li Wenjian 
Published: November 2022

Abstract
Background Carbon ion-beam irradiation has been widely used to advance crop breeding. The purpose of this study was to explore whether irradiation is suitable for mutation creation of japonica rice (Oryza sativaL.) in northeast China and its potential effects on local germplasm resources.
Methods and Results 200 Gy irradiation was applied to screened stable rice mutants, random amplified polymorphic DNA (RAPD) and simple sequence repeat (SSR) molecular markers were applied to detect the DNA polymorphisms of mutants and local varieties. Here, the mutants with a shorter maturation period than the mutagenic parent were screened. Among control (Tonghe899) and mutants, RAPD and SSR primers revealed that a total of 574 bands of which 385 were polymorphic (67.07%), all mutants had polymorphic DNA bands, and the polymorphism information content (PIC) of RAPD and SSR varied from 0.500 to 0.924 and 0.836 to 0.954, respectively. Meanwhile, among mutant and other local varieties, RAPD and SSR primers generated a total of 658 amplified bands with 530 polymorphic bands (80.55%). Notably, the addition of mutants reduced the lowest Jaccard’s similarity coefficient of the local varieties population from 0.65 to 0.62.
Conclusions In summary, carbon-ion beam irradiating rice seeds generate mutants that can develop as new cultivars, and it slightly expands the genetic diversity of the selected japonica rice from northeast China. RAPD and SSR markers had good polymorphism and could be used for DNA polymorphism identification and facilitate inter-cultivar identification for japonica rice in northeast China.
Small Volatile Inhibitors Targeting LncRNA in Radioresistant Non-small Cell Lung Cancer
Authors: Mukherjee Arnab , KS Mukunthan 
Published: November 2022

Abstract
Radiotherapy is the most crucial nonsurgical therapeutic method in the multidisciplinary care of non-small cell lung cancer (NSCLC) patients. However, radiation resistance continues to be a significant clinical issue, negatively affecting cancer prognosis in patients. The analysis of the RNA microarray dataset revealed the dysregulation of the cell cycle, evasion of apoptosis and cancer immune response. A co-expression analysis with a network pharmacology approach revealed a lncRNA (ENST00000605056) regulating three highly ranked hub genes, driving radioresistance in NSCLC cells. The small molecules that target these RNAs offer therapeutic modulation of multiple biological processes. The study comprises three volatile ligands due to their good pharmacokinetic profile to target ENST00000605056. The molecular interaction studies uncovered their high binding affinity to its binding pocket with a preponderance of non-covalent bond interactions between the ligand atoms and the nucleotides. The Molecular dynamics simulations revealed the binding stability of ligands to the long non-coding RNA (lncRNA) with a very low deviation compared to the control. This study demonstrated the ability of the small molecules to target lncRNA in overcoming the global concern of radioresistance among NSCLC patients and aid in future translational studies.
Designing and evaluation of Smartphone-based educational application of neurodevelopmental treatment in children with cerebral palsy for occupational therapists
Authors: Mostowfi Sina , dalvand Hamid , Rasanani Mohammad-Reza Hadian , Sheikhtaheri Abbas , Fard Kheirolah Rahsepar 
Published: November 2022

Abstract
Background: Smartphone applications are used as one of the learning tools in the student's learning process. Learning Neurodevelopmental Treatment approaches is necessary for occupational and physical therapist and students. The aim of the study was to design, develop and evaluate a smartphone educational NDT application of children with cerebral palsy.
Methods: After assessing the requirements and holding a panel of experts, the content of the App was determined. Thirty occupational therapy students (control= 15 and intervention= 15) were included in the study. The intervention group, in addition to attending the traditional education, used the NDT App for two weeks. QUIS questionnaire was used to measure the usability of the software. Knowledge questionnaire was taken from students before and after intervention in both control and intervention groups.
Results: The average QUIS score, indicated a high level of usability for the target group. The results showed that, the scores of knowledge in the intervention group in all areas of the app except sleep and mobility were significantly higher than the control group.
Conclusion: This study indicates that the developed App is usable for occupational therapy students and also improves students' knowledge about NDT approach of children with CP.
A periodic boundary value problem with switchingsunder nonlinear perturbations
Authors: Benner Peter , Chuiko Sergey , Zuyev Alexander 
Published: November 2022

Abstract
We investigate the existence of solutions of weakly nonlinear periodic boundary value problems for systems of ordinary differential equations with switchings and the construction of these solutions. We consider the critical case where the equation for the generating constants of a weakly nonlinear periodic boundary-value problem with switchings does not turn into an identity. We improve the classification of critical and non-critical cases and construct an iterative algorithm for finding solutions of weakly nonlinear periodic boundary value problems with switchings in the critical case. As examples of application of the constructed iterative scheme, we obtain approximations to the solutions of a periodic boundary value problem for the mathematical model of non-isothermal chemical reactions. To check the accuracy of the proposed approximations, we evaluate discrepancies in the original equation.
Time-series changes in pupil and optokinetic nystagmus in spatial attention shift
Authors: Kanari Kei , Kikuchi Moe 
Published: November 2022

Abstract
Changes in the pupil and optokinetic nystagmus (OKN) correspond not only to the luminance and motion direction at the eye position but also to those at the attentional position, respectively. This study examined changes in the spatial shift of covert attention in the pupil and OKN. A test stimulus with random dot patterns of different luminance and direction of motion was presented at a distance to the left and right of the visual field. The results showed that when attention was spatially shifted, changes in the pupil and OKN corresponded to the luminance and motion direction of the attentional stimulus, respectively. This finding suggests that the pupil and OKN can be used to estimate changes in covert attention.
Numerical analysis of CORONAVIRUS detection using Photonic Crystal Fiber based SPR Sensor
Authors: Gupta Ankur , Singh Tanu , Singh Rajat kumar , Tiwari Akhilesh 
Published: November 2022

Abstract
Coronavirus disease (COVID-19) is a worldwide health emergency caused by the coronavirus 2 (severe acute respiratory illness) (SARS-CoV-2). COVID-19 has a wide range of symptoms, making a definitive diagnosis difficult. The shortage of equipment for testing technology COVID-19 has resulted in long queues for Covid-19 testing, which is a major problem. Covid-19 testing is currently performed using sluggish and costly technology like Single photon emission computed tomography (SPECT), computed tomography (CT), positron emission tomography (PET), and enzyme-linked immunosorbent assay (ELISA).The gold standard test for diagnosing COVID-19 is real-time reverse transcriptase- polymerase chain reaction (RT-PCR), which necessitates highly skilled workers and has a lengthy turnaround time. However, rapid and affordable immunodiagnostic techniques (antigen or antibody tests) are also available with some trade off accuracy. Optical sensors are frequently employed in a variety of applications, because of their increased sensitivity, strong selectivity, rapid reaction times, and outstanding resolution. The use of Photonic crystal fiber (PCF) is advantages for the quick detection of the new coronavirus is suggested with the use of a PCF based (Au/BaTiO3/Graphene) multilayered surface plasmon resonance (SPR) biosensor. The proposed sensor can quickly detect the COVID-19 virus in two different ligand-analyte environments: (i) the virus spike receptor-binding domain (RBD) as an analyte and monoclonal antibodies (mAbs) as a probe ligand, and (ii) monoclonal antibodies (IgG or IgM) as an analyte and the virus spike RBD as a probe ligand. The finite element method (FEM) is used to quantitatively examine the performance of the PCF based multilayered SPR sensor.