bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generasi Milenial di Media Sosial: Antisipasi Terhadap Arus Radikalisme
Authors: Kholifah Latif Nur , Sari Maula 
Published: September 2022

Abstrak
Generasi milenial saat ini semakin harus lebih selektif dalam mengambil informasi karena tindakan radikalisme semakin mudah diakses dalam sosial media. Melihat banyaknya kaum milenial yang terjerumus dalam tindakan radikalisme ini. Tulisan ini bertujuan untuk mengetahui hal apa saja yang harus dilakukan untuk mengantisipasi sikap radikalisme dari sosial media. Metode yang dilakukan dalam penelitian ini ialah Metode penelitian yang digunakan dalam penelitian ini kajian pustaka atau library research dengan menggunakan analisis deskriptif. Metode ini menyajikan beragam data dan fakta dalam sejumlah literatur, baik yang sifatnya primer maupun sekunder. Penelitian ini bermaksud untuk mengeksplorasi data melalui buku-buku referensi, jurnal, dan data-data di sosial media. Hasil penelitian menunjukkan bahwa cara pengantisipasian generasi milenial terhadap radikalisme ialah; Sadari bahwa Islam itu harmonis, Mengenali makna jihad, Tidak ada jaminan manusia bunuh diri itu masuk surga, Kenali hadis dan ayat al-Qur’an secara bijaksana di media sosial.
Siberfeminizm Çerçevesinde Yeni Medyada Kadın Gazeteciler Üzerine Bir Araştırma
Authors: Kiraz Demir Selin 
Published: September 2022

Yeni medya mecraları, iletişim süreçlerinin en önemli aşamalarından biri olan geri bildirimleri en gerçek ve en hızlı haliyle kaynağa sunması bakımından son dönemde oldukça tercih edilir hale gelmiştir. Bugün, özellikle YouTube gibi platformların güncel izleme pratiklerini dönüştürdüğü söylenebilir. Fakat bu mecralarda yayınlanan videolar, içeriği ne olursa olsun, izleyicinin kendi kimliğini gizleme imkânı da sunduğundan ve herhangi bir sansür mekanizması bulunmadığından yapılan yorumlarda toplumsal cinsiyete dayalı cinsiyetçi söylemleri daha kolay yayılabilir hale de getirebilmektedir. Çalışmada, yapımcı Armağan Çağlayan’ın YouTube’da yayınlamak üzere hazırlayıp sunduğu Gör Beni adlı programında kadın gazeteci Nevşin Mengü’nün konuk olduğu bölüme yapılan yorumlar, toplumsal cinsiyet perspektifinden içerik analizi yöntemiyle incelenmiştir. Cinsiyete yönelik söylemlerde erkek ya da kadın kullanıcıların oranları, kullanıcıların kimliklerini açık olarak kullanıp kullanmadıkları, cinsiyetçi söylemin bir hakaret ya da bilinçsiz bir övgü unsuru olarak kullanılması da araştırmaya dahil edilen konular arasındadır. Araştırmada elde edilen bulgular, kadın gazetecilere yönelik cinsiyetçi söylemlerin korumacı ya da düşmanca devam ettiğini ve toplumsal cinsiyet konusundaki kalıp yargıların henüz tam anlamıyla önüne geçilemediğini göstermiştir. Ayrıca bulgular, araştırmaya dahil edilen örneklemin kamuoyundaki algısının da önemli bir etken olduğunu ortaya koymuştur. Bu araştırmanın, yeni medya mecralarında yayınlanan içerikler aracılığıyla kadın gazetecilerin maruz kaldığı cinsiyetçi söylemlerin kaynakları ve yaklaşımlar konusunda bir perspektif sunabileceği düşünülmektedir.
Anahtar Kelimeler: Toplumsal Cinsiyet, Kadın Gazeteciler, Yeni Medyada Kadın
Edukasi Mitigasi Bencana Meningkatkan Pengetahuan dan Keterampilan Masyarakat Menghadapi Bencana Gempa Bumi
Authors: Langitan Rosamey Elleke , Agusrianto Agusrianto , Oktavia Dwi Sintia , Manggasa Dafrosia Darmi 
Published: September 2022

Sulawesi Tengah merupakan daerah rawan gempa termasuk Kabupaten Tojo Una-Una dengan riwayat gempa 6,0 magnitudo. Desa Tete B salah satu desa yang mengalami dampak akibat gempa tersebut. Masyarakat panik, cemas, berhamburan keluar rumah dan mengungsi ke pegunungan. Masyarakat belum mengetahui tindakan mitigasi bencana. Kegiatan pengabdian masyakat bertujuan untuk meningkatkan pengetahuan masyakat tentang mitigasi bencana gempa bumi, dengan sasaran masyakart di desa Tete. Metode pengabdian yaitu edukasi dan demonstrasi, hasil kegiatan menunjukkan 80% masyarakat memiliki pengetahuan yang baik tentang mitigasi bencana setelah dilakukan edukasi dan mampu mendemonstrasikan tindakan mitigasi bencana. Saran bagi pemerintah setempat meningkatkan pengetahuan dan kesiapsiagaan masyarakat dalam menghadapi bencana melalui kegiatan edukasi dan simulasi secara berkala dengan melibatkan seluruh elemen masyarakat
Biohybrid elastin-like venous valve with potential for in situ tissue engineering
Authors: González-Pérez Fernando , Acosta Sergio , Rütten Stephan , Emonts Caroline , Kopp Alexander , Henke Heinz-Werner , Bruners Philipp , Gries Thomas , Rodríguez-Cabello J. Carlos , Jockenhoevel Stefan , Fernández-Colino Alicia 
Published: September 2022

Chronic venous insufficiency (CVI) is a leading vascular disease whose clinical manifestations include varicose veins, edemas, venous ulcers, and venous hypertension, among others. Therapies targeting this medical issue are scarce, and so far, no single venous valve prosthesis is clinically available. Herein, we have designed a bi-leaflet transcatheter venous valve that consists of (i) elastin-like recombinamers, (ii) a textile mesh reinforcement, and (iii) a bioabsorbable magnesium stent structure. Mechanical characterization of the resulting biohybrid elastin-like venous valves (EVV) showed an anisotropic behavior equivalent to the native bovine saphenous vein valves and mechanical strength suitable for vascular implantation. The EVV also featured minimal hemolysis and platelet adhesion, besides actively supporting endothelialization in vitro, thus setting the basis for its application as an in situ tissue engineering implant. In addition, the hydrodynamic testing in a pulsatile bioreactor demonstrated excellent hemodynamic valve performance, with minimal regurgitation (&lt;10%) and pressure drop (&lt;5 mmHg). No stagnation points were detected and an in vitro simulated transcatheter delivery showed the ability of the venous valve to withstand the implantation procedure. These results present a promising concept of a biohybrid transcatheter venous valve as an off-the-shelf implant, with great potential to provide clinical solutions for CVI treatment.
Revealing the effect of 2D carbides with different metal sites for improving hydrogen storage in MgH2
Authors: Ren Kaixiang , Wang Bingbing 
Published: September 2022

Two-dimensional (2D) carbon materials are considered as efficient catalysts for improving hydrogen storage in MgH2, but their catalytic mechanisms of different materials remain unclear. Herein we compare the hydrogen storage properties of MgH2 with doping different 2D carbon materials for revealing their catalytic effecting mechanisms. It can be seen that the effect of 2D metal carbides including Nb2C and Ti2C are superior to 2D graphene for improving hydrogen storage properties of MgH2, where the Ti2C exhibits the best catalytic effect with a remarkable decrease of activation energy (Ea) from ∼124 kJ/mol for doping graphene to ∼86 kJ/mol. This is related to the changes of individual metal and graphite chemical valence states of catalysts. The high catalytic activity of the hydrogen storage reaction originates from its unique layered structure and in situ formation of MHX, i.e., the tiny metal crystals can serve as a channel to facilitate hydrogen transport in MgH2 matrix. Moreover, the Ti catalytic effect is better than Nb, which originates from the surface of the multivalent Ti atoms is an intermediate of the electron moving between H− and Mg2+, thus leading to the Ti2C catalyzed MgH2 with superior hydrogen kinetic and cyclic performance.
The predictive value of CatLet© angiographic scoring system for long-term prognosis in patients with acute myocardial infarction presenting > 12 h after symptom onset
Authors: Wang Heng , He Yi , Fan Jia-Li , Li Xu , Zhou Bing-Yuan , Jiang Ting-Bo , He Yong-Ming 
Published: September 2022

BackgroundWe have recently developed the Coronary Artery Tree description and Lesion EvaluaTion (CatLet©) angiographic scoring system, which is capable of accounting for the variability in coronary anatomy, and risk-stratifying patients with coronary artery disease. This study aimed to clarify whether the CatLet score had a predictive value for long-term prognosis in patients with acute myocardial infarction (AMI) presenting &gt; 12 h after symptom onset.Materials and methodsThe CatLet score was calculated for 1,018 consecutively enrolled AMI patients, who were divided into 3 groups according to the CatLet score tertiles. The primary endpoint was major adverse cardiac events (MACEs), defined as a composite of myocardial infarction, cardiac death, and ischemia-driven revascularization; secondary endpoints were all-cause death, cardiac death, myocardial infarction, and ischemia-driven revascularization.ResultsThe CatLet score was capable of predicting long-term prognosis at a median 4.9-year follow-up alone or after adjustment for risk factors. Multivariable-adjusted hazard ratios (95% CI)/unit higher score were 1.06 (1.05–1.08) for MACEs, 1.05 (1.03–1.07) for all-cause death, 1.06 (1.04–1.09) for cardiac death, 1.06 (1.04–1.08) for myocardial infarction, and 1.06 (1.04–1.08) for revascularization. The univariate model showed good calibration (χ2 = 8.25, P = 0.4091) and good discrimination (area under ROC curve = 0.7086) for MACEs.ConclusionThe CatLet score is an independent predictor of long-term clinical outcomes of patients with AMI presenting &gt; 12 h after symptom onset (http://www.chictr.org.cn; Registry Number: ChiCTR2000033730).
A novel marker based on necroptosis-related long non-coding RNA for forecasting prognostic in patients with clear cell renal cell carcinoma
Authors: Lv Jinxing , Xu Qinghui , Wu Guoqing , Hou Jian , Yang Guang , Tang Cheng , Qu Genyi , Xu Yong 
Published: September 2022

Background: The incidence of clear cell renal cell carcinoma (ccRCC) is high and has increased gradually in recent years. At present, due to the lack of effective prognostic indicators, the prognosis of ccRCC patients is greatly affected.Necroptosis is a type of cell death, and along with cell necrosis is considered a new cancer treatment strategy. The aim of this study was to construct a new marker for predicting the prognosis of ccRCC patients based on long non-coding RNA (nrlncRNAs) associated with necroptosis.Methods: RNA sequence data and clinical information of ccRCC patients from the Cancer Genome Atlas database (TCGA) were downloaded. NrlncRNA was identified by Pearson correlation study. The differentially expressed nrlncRNA and nrlncRNA pairs were identified by univariate Cox regression and Lasso-Cox regression. Finally, a Kaplan-Meier survival study, Cox regression, clinicopathological features correlation study, and receiver operating characteristic (ROC) spectrum were used to evaluate the prediction ability of 25-nrlncrnas for markers. In addition, correlations between the risk values and sensitivity to tumor-infiltrating immune cells, immune checkpoint inhibitors, and targeted drugs were also investigated.Results: In the current research, a novel marker of 25-nrlncRNAs pairs was developed to improve prognostic prediction in patients with ccRCC. Compared with clinicopathological features, nrlncRNAs had a higher diagnostic validity for markers, with the 1-year, 3-years, and 5-years operating characteristic regions being 0.902, 0.835, and 0.856, respectively, and compared with the stage of 0.868, an increase of 0.034. Cox regression and stratified survival studies showed that this marker could be an independent predictor of ccRCC patients. In addition, patients with different risk scores had significant differences in tumor-infiltrating immune cells, immune checkpoint, and semi-inhibitory concentration of targeted drugs. The feature could be used to evaluate the clinical efficacy of immunotherapy and targeted drug therapy.Conclusion: 25-nrlncRNAs pair markers may help to evaluate the prognosis and molecular characteristics of ccRCC patients, which improve treatment methods and can be more used in clinical practice.
A necroptosis-related prognostic model for predicting prognosis, immune landscape, and drug sensitivity in hepatocellular carcinoma based on single-cell sequencing analysis and weighted co-expression network
Authors: Li Jingjing , Wu Zhi , Wang Shuchen , Li Chan , Zhuang Xuhui , He Yuewen , Xu Jianmei , Su Meiyi , Wang Yong , Ma Wuhua , Fan Dehui , Yue Ting 
Published: September 2022

Background: Hepatocellular carcinoma (HCC) is a highly lethal cancer and is the second leading cause of cancer-related deaths worldwide. Unlike apoptosis, necroptosis (NCPS) triggers an immune response by releasing damage-related molecular factors. However, the clinical prognostic features of necroptosis-associated genes in HCC are still not fully explored.Methods: We analyzed the single-cell datasets GSE125449 and GSE151530 from the GEO database and performed weighted co-expression network analysis on the TCGA data to identify the necroptosis genes. A prognostic model was built using COX and Lasso regression. In addition, we performed an analysis of survival, immunity microenvironment, and mutation. Furthermore, the hub genes and pathways associated with HCC were localized within the single-cell atlas.Results: Patients with HCC in the TCGA and ICGC cohorts were classified using a necroptosis-related model with significant differences in survival times between high- and low-NCPS groups (p &lt; 0.05). High-NCPS patients expressed more immune checkpoint-related genes, suggesting immunotherapy and some chemotherapies might prove beneficial to them. In addition, a single-cell sequencing approach was conducted to investigate the expression of hub genes and associated signaling pathways in different cell types.Conclusion: Through the analysis of single-cell and bulk multi-omics sequencing data, we constructed a prognostic model related to necroptosis and explored the relationship between high- and low-NCPS groups and immune cell infiltration in HCC. This provides a new reference for further understanding the role of necroptosis in HCC.
Predictors of visual acuity improvement after phacoemulsification cataract surgery
Authors: AlRyalat Saif Aldeen , Atieh Duha , AlHabashneh Ayed , Hassouneh Mariam , Toukan Rama , Alawamleh Renad , Alshammari Taher , Abu-Ameerh Mohammed 
Published: September 2022

PurposeThis study aimed to assess preoperative predictors of visual outcome after phacoemulsification cataract surgery in Jordan, a Middle Eastern country.MethodsThis was a retrospective longitudinal study of adult patients who underwent phacoemulsification cataract surgery from January 2019 to July 2021. For each patient, we included only the first operated eye. We obtained pre-operative ocular history, cataract surgery complication risk based on a predesigned score, visual acuity, best correction, and best corrected visual acuity. We recorded intraoperative complications. We also obtained postoperative best corrected visual acuity and refractive error for correction after 1–3 months.ResultsA total of 1,370 patients were included in this study, with a mean age of 66.39 (± 9.48). 48.4% of patients achieved visual acuity ≥ 0.8, and 72.7% achieved visual acuity ≥ 0.5. The mean visual acuity improvement after phacoemulsification cataract surgery was 0.33 (95% CI 0.31–0.35). In the regression model, significant predictors that affected visual acuity improvement included the presence of diabetic retinopathy, glaucoma, and complication risk factors (i.e., high-risk surgery).ConclusionPredictors of visual acuity improvement vary between studies. This study was conducted in a developing country; we defined predictors of visual acuity improvement. We also provided a new preoperative phacoemulsification cataract surgery complication risk score.
Nutritional immunomodulation of Atlantic salmon response to Renibacterium salmoninarum bacterin
Authors: Emam Mohamed , Eslamloo Khalil , Caballero-Solares Albert , Lorenz Evandro Kleber , Xue Xi , Umasuthan Navaneethaiyer , Gnanagobal Hajarooba , Santander Javier , Taylor Richard G. , Balder Rachel , Parrish Christopher C. , Rise Matthew L. 
Published: September 2022

We investigated the immunomodulatory effect of varying levels of dietary ω6/ω3 fatty acids (FA) on Atlantic salmon (Salmo salar) antibacterial response. Two groups were fed either high-18:3ω3 or high-18:2ω6 FA diets for 8 weeks, and a third group was fed for 4 weeks on the high-18:2ω6 diet followed by 4 weeks on the high-18:3ω3 diet and termed “switched-diet”. Following the second 4 weeks of feeding (i.e., at 8 weeks), head kidney tissues from all groups were sampled for FA analysis. Fish were then intraperitoneally injected with either a formalin-killedRenibacterium salmoninarumbacterin (5 × 107cells mL−1) or phosphate-buffered saline (PBS control), and head kidney tissues for gene expression analysis were sampled at 24 h post-injection. FA analysis showed that the head kidney profile reflected the dietary FA, especially for C18FAs. The qPCR analyses of twenty-three genes showed that both the high-ω6 and high-ω3 groups had significant bacterin-dependent induction of some transcripts involved in lipid metabolism (ch25haandlipe), pathogen recognition (clec12bandtlr5), and immune effectors (znrf1andcish).In contrast, these transcripts did not significantly respond to the bacterin in the “switched-diet” group. Concurrently, biomarkers encoding proteins with putative roles in biotic inflammatory response (tnfrsf6b) and dendritic cell maturation (ccl13) were upregulated, and a chemokine receptor (cxcr1) was downregulated with the bacterin injection regardless of the experimental diets. On the other hand, an inflammatory regulator biomarker,bcl3, was only significantly upregulated in the high-ω3 fed group, and a C-type lectin family member (clec3a) was only significantly downregulated in the switched-diet group with the bacterin injection (compared with diet-matched PBS-injected controls). Transcript fold-change (FC: bacterin/PBS) showed thattlr5was significantly over 2-fold higher in the high-18:2ω6 diet group compared with other diet groups. FC and FA associations highlighted the role of DGLA (20:3ω6; anti-inflammatory) and/or EPA (20:5ω3; anti-inflammatory) vs. ARA (20:4ω6; pro-inflammatory) as representative of the anti-inflammatory/pro-inflammatory balance between eicosanoid precursors. Also, the correlations revealed associations of FA proportions (% total FA) and FA ratios with several eicosanoid and immune receptor biomarkers (e.g., DGLA/ARA significant positive correlation withpgds,5loxa,5loxb,tlr5, andcxcr1). In summary, dietary FA profiles and/or regimens modulated the expression of some immune-relevant genes in Atlantic salmon injected withR. salmoninarumbacterin. The modulation of Atlantic salmon responses to bacterial pathogens and their associated antigens using high-ω6/high-ω3 diets warrants further investigation.
A comprehensive next generation sequencing tissue assay for Asian-prevalent cancers—Analytical validation and performance evaluation with clinical samples
Authors: Ng Cedric Chuan-Young , Lim Sandy , Lim Abner Herbert , Md Nasir Nur Diyana , Zhang Jingxian , Rajasegaran Vikneswari , Lee Jing Yi , Kok Jessica Sook Ting , Thike Aye Aye , Lim Johnathan Xiande , Weng Ruifen , Yee Sidney , Choudhury Yukti , Chan Jason Yongsheng , Tan Puay Hoon , Tan Min-Han , Teh Bin Tean 
Published: September 2022

Introduction: A well-validated diagnostic assay with curated biomarkers complements clinicopathological factors to facilitate early diagnosis and ensure timely treatment delivery. This study focuses on an Asian-centric cancer diagnostic assay designed and thoroughly validated against commercially available standard references and a cohort of over 200 clinical specimens spanning 12 diverse Asian-centric cancer types.Methods: The assay uses hybrid-capture probes capable of profiling DNA aberrations from 572 cancer-related genes and 91 RNA fusion partners. The panel can detect clinically-tractable biomarkers such as microsatellite instability (MSI) and tumor mutation burden (TMB).Results: Analytical evaluation demonstrated 100% specificity and 99.9% sensitivity within a ≥5% VAF limit of detection (LoD) for SNV/Indels. RNA-based fusion features an LoD of ≥5 copies per nanogram input when evaluated against commercial references. Excellent linearity and concordance were observed when benchmarking against orthogonal methods in identifying MSI status, TMB scores and RNA fusions. Actionable genetic alterations were identified in 65% of the clinical samples.Conclusion: These results demonstrate a molecular diagnostic assay that accurately detects genomic alterations and complex biomarkers. The data also supports an excellent performance of this assay for making critical diagnoses and well-informed therapeutic decisions in Asian prevalent cancers.
Preoperative homocysteine modifies the association between postoperative C-reactive protein and postoperative delirium
Authors: Ma Xin , Mei Xinchun , Tang Tianyi , Wang Meijuan , Wei Xiaoyi , Zheng Hailin , Cao Jing , Zheng Hui , Cody Kathryn , Xiong Lize , Marcantonio Edward R. , Xie Zhongcong , Shen Yuan 
Published: September 2022

BackgroundHomocysteine and C-reactive protein (CRP) may serve as biomarkers of postoperative delirium. We set out to compare the role of blood concentration of homocysteine versus CRP in predicting postoperative delirium in patients.Materials and methodsIn this prospective observational cohort study, the plasma concentration of preoperative homocysteine and postoperative CRP was measured. Delirium incidence and severity within 3 days postoperatively were determined using the Confusion Assessment Method and Confusion Assessment Method-Severity algorithm.ResultsOf 143 participants [69% female, median (interquartile range, 25th–75th) age of 71 (67–76) years] who had knee or hip surgery under general anesthesia, 44 (31%) participants developed postoperative delirium. Postoperative plasma concentration of CRP was associated with postoperative delirium incidence [adjusted odds ratio (OR) per one standard deviation change in CRP: 1.51; 95% Confidence Interval (CI): 1.05, 2.16;P= 0.026], and severity [in which each one standard deviation increase in postoperative CRP was associated with a 0.47 point (95% CI: 0.18–0.76) increase in the severity of delirium,P= 0.002] after adjusting age, sex, preoperative Mini-Mental State Examination score and the days when postoperative CRP was measured. A statistically significant interaction (adjustedP= 0.044) was also observed, in which the association between postoperative plasma concentration of CRP and postoperative delirium incidence was stronger in the participants with lower preoperative plasma concentrations of homocysteine compared to those with higher preoperative levels.ConclusionPending validation studies, these data suggest that preoperative plasma concentration of homocysteine modifies the established association between postoperative plasma concentration of CRP and postoperative delirium incidence.