bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ursolic acid silences CYP19A1/aromatase to suppress gastric cancer growth
Authors: Ma Wen‐Lung , Chang Ning , Yu Yingchun , Su Yu‐Ting , Chen Guan‐Yu , Cheng Wei‐Chung , Wu Yang‐Chang , Li Ching‐Chia , Chang Wei‐Chun , Yang Juan‐Cheng 
Published: May 2022

AbstractIntroductionGastric cancer (GCa) is a malignancy with few effective treatments. Ursolic acid (UA), a bioactive triterpenoid enriched in Hedyotis diffusa Willd, known to suppress GCa without identified target. CYP19A1 (cytochrome P450 family 19A1; also known as aromatase, Ar) was correlated to GCa prognosis. Relatedly, Ar silencers, which halt the expression of Ar exhibited anti‐GCa effects in experimental models, are currently being investigated.MethodThe docking simulation score of UA was compared with Ar inhibitors, e.g., letrozole, exemestane, in Ar protein crystallization. Hedyotis diffusa Willd ethanol extract, UA, or 5‐fluracil were applied onto AGS, SC‐M1, MKN45 GCa cells for cancer inhibition tests. Immunoblot for measuring gene expressions upon drug treatments, or gene knockdown/overexpression. Treatments were also applied in a MKN45 implantation tumor model. A web‐based GCa cohort for Ar expression association with prognosis was performed.ResultThe ethanol extracts of Hedyotis diffusa Willd, enrich with UA, exhibited cytotoxic activity against GCa cells. Molecular docking simulations with the 3D Ar structure revealed an excellent fitting score for UA. UA increase cytotoxic, and suppressed colony, in addition to its Ar silencing capacity. Moreover, UA synergistically facilitated 5‐FU, (a standard GCa treatment) regimen in vitro. Consistent with those results, adding estradiol did not reverse the cancer‐suppressing effects of UA, which confirmed UA acts as an Ar silencer. Furthermore, UA exhibited tumor‐suppressing index (TSI) score of 90% over a 6‐week treatment term when used for single dosing in xenograft tumor model. In the clinical setting, Ar expression was found to be higher in GCa tumors than normal parental tissue from the TCGA (The Cancer Genome Atlas) cohort, while high Ar expression associated with poor prognosis. Together, the results indicate UA could be used to treat GCa by silencing Ar expression in GCa. Hedyotis diffusa Willd ethanol extract could be an functional food supplements.
Advanced Insights into Catalytic and Structural Features of the Zinc‐Dependent Alcohol Dehydrogenase from Thauera aromatica
Authors: Stark Frances , Loderer Christoph , Petchey Mark , Grogan Gideon , Ansorge‐Schumacher Marion B. 
Published: May 2022

AbstractThe asymmetric reduction of ketones to chiral hydroxyl compounds by alcohol dehydrogenases (ADHs) is an established strategy for the provision of valuable precursors for fine chemicals and pharmaceutics. However, most ADHs favor linear aliphatic and aromatic carbonyl compounds, and suitable biocatalysts with preference for cyclic ketones and diketones are still scarce. Among the few candidates, the alcohol dehydrogenase from Thauera aromatica (ThaADH) stands out with a high activity for the reduction of the cyclic α‐diketone 1,2‐cyclohexanedione to the corresponding α‐hydroxy ketone. This study elucidates catalytic and structural features of the enzyme. ThaADH showed a remarkable thermal and pH stability as well as stability in the presence of polar solvents. A thorough description of the substrate scope combined with the resolution and description of the crystal structure, demonstrated a strong preference of ThaADH for cyclic α‐substituted cyclohexanones, and indicated structural determinants responsible for the unique substrate acceptance.
Pneumoparotid related to obstructive sleep apnea syndrome treated by oral appliance with anterior opening to reduce intraoral pressure
Authors: Yoshida Kazuya 
Published: May 2022

AbstractPneumoparotid is associated with retrograde air insufflation in Stensen's duct and the parotid gland. A 57‐year‐old man experienced swelling and pain in the right parotid region after sleeping during a flight. Pneumoparotid and obstructive sleep apnea syndrome were diagnosed. Pneumoparotid was suspected as caused by increased intraoral pressure during sleep; thus, an oral appliance to reduce intraoral pressure was effective. After 9 years, the symptoms recurred on the left side. The appliance was reinserted and helped substantially. This is the first case report of obstructive sleep apnea syndrome accompanying pneumoparotid, treated effectively with an oral appliance, with a 10‐year follow‐up.
Left ventricular thrombosis and endogenous endophthalmitis in the setting of COVID‐19: A case report
Authors: Zibaeenezhad Mohammad Javad , Moaref Alireza , Abtahi Firoozeh , Moghadami Mohsen , Johari Mohammad Karim , Ardekani Ali , Keshavarz Mohammad 
Published: May 2022

AbstractAside from typical pneumonia, the coronavirus disease 2019 (COVID‐19) has shown several extra‐pulmonary manifestations. This study was done on a 66‐year‐old male patient who concomitantly had endogenous endophthalmitis and left ventricular thrombosis one month after being hospitalized due to COVID‐19.
A Foam‐Expansion and Wall‐Evolution Model for Scaffold Fabrication Using Supercritical CO2 Foaming
Authors: Hatami Tahmasb , Cidreira Anne Carolyne Mendonça , Linan Lamia Zuniga , Innocentini Mei Lucia Helena 
Published: May 2022

AbstractSupercritical CO2 foaming (SCF) is a green and highly controllable technique to fabricate polymer scaffolds. In the current work, SCF was modeled mathematically by combining a foam‐expansion model (FEM) and a wall‐evolution model (WEM). The model package is clearly presented, its solution strategy is precisely described, and its superiority over FEM is demonstrated. The model was validated by using experimental data of poly(ε‐caprolactone) scaffolds fabricated by the SCF technique at 300 bar and 50 °C with first and second pressure releases of 28.6 and 200 bar min−1, respectively. It was revealed that coupling FEM and WEM enables the prediction of scaffold density, pore radius, pore geometry, and wall thickness at the same time.
Using Hybrid Coupling Processes for the Treatment of Waste Containing Halosulfuron‐Methyl Herbicide
Authors: Souza Fernanda L. , Linares José J. , Ferreira Neidenei G. , Lanza(s) Marcos R. V. 
Published: May 2022

AbstractThis work aims to demonstrate the importance of coupling different degradation processes for the removal of the commercial herbicide Halosulfuron‐Methyl (HSM). Using anode oxidation (AO) on boron‐doped diamond as the base process; cathodically produced H2O2 (AO/H2O2), UV light (AO/UV), AO/UV/H2O2, electro‐Fenton and photoelectron Fenton (PEF) are employed as hybrid processes for HSM degradation. All hybrid processes employed in the study exhibited synergism with AO, and the UV‐irradiated processes presented an outstanding performance. In particular, the AO/UV/H2O2 process exhibited 90 % mineralization after 3 h of treatment, whereas the PEF process exhibited a complete removal of HSM after 45 min of treatment. In addition to the noticeable advantages of hybridization, the application of higher current densities is found to accelerate the degradation/mineralization of the compound of interest, although the process tends to be more energy demanding. In such a case, the use of a hybrid treatment process coupled to UV‐irradiation allows one to mitigate this constraint while contributing toward obtaining higher mineralization degrees. The degradation/mineralization of more concentrated solutions is, however, found to occur more sluggishly under the treatment mechanisms investigated here, requiring longer times, although the process is noticeably more efficient in photo‐irradiated processes, which recorded current efficiencies of above 100 %.
Perovskite LaSrCoFeO6 Oxide Enabled Visible Light Catalytic Aerobic Epoxidation of Styrene
Authors: Ke Qingping , Fang Shuai , Tang Jun , Li Fengfeng , Ning Chuantao , Tang Zhicheng , Ling Qiang , Liu Xiangchun , Cui Ping 
Published: May 2022

AbstractIn the search for a highly efficient heterogeneous catalyst for the epoxidation of styrene, it is still a challenge to develop a system that simultaneously possesses superior catalytic activity and selectivity under aerobic conditions. Herein, we report the use of perovskite LaSrCoFeO6 (LSCF) as a heterogeneous and visible‐light catalyst, and determine that LSCF acts as a highly efficient catalyst for the epoxidation of styrene under aerobic conditions. The formation of 1O2 species transformed from O2⋅− species were proposed as reactive oxygen species for the epoxidation of styrene over the LSCF catalyst, where the directional generation of O2⋅− species on the LSCF catalyst is the key step to yield highly selective epoxidation of styrene. The experimental results of styrene epoxidation show that when the molar ratio of styrene and LSCF catalyst is 150 : 1 and the reaction is under the conditions of visible light (440 nm) and 100 °C for 6 h, the conversion of styrene and selectivity of styrene oxide reached 99.9 % and 80.3 %, respectively. The reaction rate over LSCF catalyst is as high as 50 mmol ⋅ gcat−1 ⋅ h−1. In addition, the reaction kinetics of the epoxidation of styrene over LSCF catalyst was systematically studied.
Sustainable Production of Bioactive Molecules from C‐Lignin‐Derived Propenylcatechol
Authors: Song Weihong , Du Qinglian , Li Xiancheng , Wang Shuizhong , Song Guoyong 
Published: May 2022

AbstractCatechyl lignin (C‐lignin) is a naturally occurring linear homogeneous biopolymer composed solely of caffeyl alcohol subunits with cleavable benzodioxane linkages. The inherent structural features of propenylcatechol, a direct depolymerized product of castor seed coats C‐lignin, render it a sustainable and promising platform for the synthesis of bioactive molecules. Herein, diversified transformations of propenylcatechol, including C=C bond difunctionalization, β‐modification, β,γ‐rearrangement, and γ‐methyl derivatization, were reported based on known or developed methods. A series of functional molecular skeletons involved in the current synthetic routes for the preparation of pharmaceuticals and bioactive molecules were obtained. Starting from castor seed coats, annuloline (natural product) and CC‐5079 (antitumor) were synthesized using facile and inexpensive reagents in only four‐ and five‐sequence reactions, respectively, thereby demonstrating a superior step‐efficiency to that of reported synthetic routes. Almost all atoms in the C‐lignin biopolymer were incorporated into the final products owing to the intrinsic structures of naturally occurring C‐lignin. Bioactive molecules produced from C‐lignin integrate a low‐carbon footprint with high‐quality and economical manufacture of pharmaceuticals.
Input‐voltage and output‐current equalization of series‐in parallel‐out three‐phase multi‐module voltage source converter‐based high voltage direct current shunt tap
Authors: Elserougi Ahmed A. 
Published: May 2022

AbstractConventionally, high voltage direct current (HVDC) shunt taps are used to feed a three‐phase local network by employing a DC‐AC 2‐Level voltage source converter (2L‐VSC), where its DC side is connected to the DC‐link voltage, while its AC side is fed to a step‐down transformer to meet the local network voltage level. To meet the high‐voltage ratings of the 2L‐VSC, series‐connected Insulated‐Gate Bipolar Transistors (IGBTs) should be employed with proper static and dynamic voltage sharing of the involved IGBTs per each valve. To avoid the complexity and challenges of series‐connected devices, an alternative solution for HVDC shunt tap is proposed in this paper, where DC‐AC inverter based on series‐input parallel‐output multi‐module 2L‐VSCs with input‐voltages and output‐currents equalization is employed, which enables employing of IGBTs with relatively medium‐voltage rating. In the proposed architecture, the AC sides of VSCs are fed to step‐down transformers, where the transformers' secondary sides are connected in parallel for current sharing purpose. Simulation results for normal as well as abnormal operating condition are presented to show the dynamic performance of the proposed architecture and validate the presented voltage and currents equalization techniques. The proposed architecture is also compared with the other existing options to show the effectiveness of the suggested approach.
Survey on energy efficient dynamic sink optimum routing for wireless sensor network and communication technologies
Authors: Gupta Susheel Kumar , Singh Shailendra 
Published: May 2022

SummaryWireless sensor network (WSN) is frequently being used for increasing the data collection and monitoring critical parameters. Major challenge in WSN design is achieving the better energy efficiency and latency considering the dynamic sink location. Lots of research has been done for improving the performance of WSN systems in wide range of applications. Prime goal of this paper is to evaluate the performance of WSN routing under the grid‐based dynamic sink locations. Later the performance of various existing critical protocols is compared to route data over centralized server. Various applications of WSNs are tabulated along with the sensor utilization. The paper contributed in three passes. Initial contribution of this research is to identify the issues and limitations of present WSN communication technologies. The paper contributed to present a case study to discover the implications of dynamic sink routing for building protocol to extend network's lifetime. The effectiveness of several clustering‐based WSN routing algorithms is first compared in this paper. After that, the protocol with the longest network life is put to the test under a grid‐based dynamic sink routing scenario. The significance of clustering‐based protocols for improving lifetime of the network is evaluated as case study. The clustering‐based energy efficient protocol like low energy adaptive clustering hierarchy (LEACH) and its different variants, PEGASIS, SEP, DEC, their variants, and so on, are compared in this paper. Various performance metrics like network delays, throughput, latency, energy consumption and network lifetime are defined for studying routing protocols. Significance of dynamic sink locations performance is evaluated for Enhanced Distributed Energy Efficient Clustering (EDEEC) protocol. Overall paper covers and reviewed many critical design aspects for WSN networks.
More than meets the eye: Examining physiological and behavioral regulation during delay of gratification task
Authors: Raghunathan Radhika S. , DiPietro Janet A. , Knudsen Nicole , Musci Rashelle J. , Johnson Sara B. 
Published: May 2022

AbstractChildren continually encounter situations where they must regulate impulsive responses to achieve a goal, requiring both self‐control (SC) and delay of gratification. We examined concurrent behavioral SC strategies (fidgeting, vocalizations, anticipation) and physiological regulation (heart rate [HR], respiratory sinus arrhythmia [RSA]) in 126 children (M (SD) = 5.4 (0.29) years) during a standard delay of gratification task. Latent variable models derived latent SC classes and examined the moderating role of HR/RSA on SC and delay ability. Three classes of SC were identified: passive: low fidgeting and vocalizations, moderate anticipation; active: moderate fidgeting, low vocalizations, and high anticipation; and disruptive: moderate fidgeting, high vocalizations, and high anticipation. Children in the active class had the lowest odds of delaying full task time, compared to children in the passive (OR = 0.67, z = −5.25, p < .001) and disruptive classes (OR = 0.76, z = −2.03, p = .04). RSA changes during the task moderated the relationship between SC class and delay ability for children in the active class (aOR = 0.92, z = −3.1, p < .01). Within the group who struggled to delay gratification (active class), a subset exhibiting appropriate autonomic regulation was able to delay. The findings suggest probing congruency of observed behavioral and unobserved physiological regulation.
Metal Organic Frameworks for Bioelectrochemical Applications
Authors: Auer Bernhard , Telfer Shane G. , Gross A. J. 
Published: May 2022

AbstractMetal organic frameworks (MOFs) with their high pore volumes and chemically‐diverse pore environments have emerged as components of catalytic electrodes for biosensors, biofuel cells, and bioreactors. MOFs are widely exploited for gas capture, separations, and catalysis, but their integration at electrodes with biocatalysts for (bio)electrocatalysis is a niche topic that remains largely unexplored. This review focuses on recent advances in MOF and MOF‐derived carbon electrodes for bioelectrochemical applications. A range of MOF materials and their integration into devices with enzymes and microbes are reported. Key properties and performance characteristics are considered and opportunities facing MOFs for (bio)electrochemical applications are discussed.
A review on theoretical studies of structural and optoelectronic properties of FA‐based perovskite materials with a focus on FAPbI3
Authors: RaeisianAsl Maryam , Panahi S. Fateme K. S. , Jamaati Maryam , Tafreshi Saeedeh Sarabadani 
Published: May 2022

SummaryOrganic‐inorganic hybrid perovskite materials have captured many researchers' interest in solar cell application during the last decade. Due to their astonishing photoelectric properties and rapid increase in efficiency, these materials are promising candidates for affordable solar cell technologies and optoelectronic devices. Also, with respect to their high‐power conversion efficiency (PCE), cost‐effectiveness, gap tunability, longer charge diffusion length, much improved photochemical and thermal stability, formamidinium (FA)‐based perovskites are one of the most promising materials as well. However, the easy formation of non‐perovskite δ‐phase formamidinium at low temperatures and toxic Pb is disadvantageous. It is worth mentioning that various strategies have been developed to stabilize α‐phase FAPbI3 at room temperature and decrease the toxicity of lead element while retaining their good performances. The current review highlights the recent theoretical progress in stabilization, bandgap engineering, and optical performance of these promising materials.
Effect of extraction methods on the efficiency of sumac (Rhus coriaria L.) fruit extract in soybean oil quality during accelerated conditions
Authors: Rahmati Sepideh , Bazargani‐Gilani Behnaz , Aghajani Narjes 
Published: May 2022

AbstractHerbal extracts containing natural bioactive substances with numerous beneficial effects have been recently noticed as appropriate alternatives for synthetic food preservatives. In this study, we aimed to optimize the effects of different sumac (Rhus coriaria) fruit extracts (SFE) on oxidative stability of soybean oil under accelerated conditions compared to a synthetic antioxidant. Hydro‐ethanolic extracts (70%) of sumac fruits were prepared by three methods of immersion (I‐SFE), ultrasound (U‐SFE), and microwave (M‐SFE). According to the response surface methodology (RSM), 13 runs were considered in the concentrations of 0, 500, and 1000 ppm of each extract that were added to the soybean oil and stored at 60°C for a 20‐day period. All of the treatments were significantly (p < .05) efficient in preventing the chemical and sensory changes of soybean oil compared to the control in the dose‐dependent manner during storage period. I‐SFE treatment showed the lowest peroxide value (PV) (0.000063 meq (milliequivalents) O2/kg oil), thiobarbituric acid reactive substances (TBARS) (115.06 MDA (malondialdehyde)/kg oil), and acid value (0.0169 mg KOH (potassium hydroxide)/kg oil) among the other extracts at the end of the storage period. Furthermore, I‐SFE treatment earned the highest sensory scores (flavor, color, odor, and overall acceptability) of soybean oil in the range of 4–5 in comparison to the other treatments and synthetic antioxidant during storage time. According to the analysis of RSM, I‐SFE in the concentration of 999.998 ppm could optimally enhance the shelf life of soybean oil for 11.3614 days under accelerated conditions. It was concluded that I‐SFE with the same efficiency as synthetic antioxidants can be considered as a suitable alternative in soybean oil with various health benefits.
A computational study on the MHD Casson fluid flow with thermal radiation and variable physical properties under the influence of Soret and Dufour effects
Authors: Govindaraj N. , Iyyappan G. , Singh A. K. , Shukla Pankaj , Roy S. 
Published: May 2022

AbstractThis research study discusses the flow of a magnetohydrodynamic Casson fluid under the influence of Soret, Dufour, and thermal radiation. Nonlinear partial differential equation (PDE) of governing equations is transformed into a dimensionless version of the modified PDEs presented in terms of dimensionless parameters. The solution of coupled PDEs is obtained by the finite difference method with a combination of the quasilinearization technique. The effects of various dimensionless parameters are shown graphically, such as buoyancy force (), concentration buoyancy force , Casson parameter (), magnetic parameter (), thermal radiation (), Darcy parameter (), Forchheimer (fr), Dufour (), Soret (Sor), Brownian motion (), thermopohersis (), and Lewis number (). Prevention of heat transfer in the industrial system is critical, the velocity behavior (), thermal variation (), and concentration profile () are more prominent in the roles of coal, gas, and solar thermal collectors.
Do headwater lakes moderate downstream temperature response to forest harvesting? Illustrating opportunities and obstacles associated with virtual experiments
Authors: Leach Jason A. , Moore R. Dan , Laudon Hjalmar , Buahin Caleb A. , Neilson Bethany T. 
Published: May 2022

AbstractThere are concerns that environmental changes, such as climate variability and forest harvesting, are altering stream thermal regimes and impacting aquatic ecosystems. Previous studies have suggested that the abundant headwater lakes found in northern landscapes may moderate downstream temperature response to forest harvesting. We investigated this hypothesis using a virtual experimental approach based on detailed field measurements made at boreal catchments in northern Sweden coupled with a process‐based stream temperature model. We simulated streamside harvesting for stream reaches with and without a headwater lake. Mean daily summer stream temperature response to harvesting was generally between 0.5 and 1.5°C higher for the stream without a lake than for the stream with a lake. However, during rain events the stream with the lake showed a greater stream temperature response than the stream without a lake. Headwater lakes typically store and delay runoff from rain events, augment baseflow, and have elevated outflow temperatures. These differences in upstream boundary conditions, in terms of flow and water temperature, were the key drivers for the contrasting harvest responses between streams with and without headwater lakes. These findings were generally consistent across different harvesting scenarios; however, uncertainty in the hyporheic term and post‐harvest microclimate conditions influenced the simulated magnitude of post‐harvest stream temperature response. Our study highlights the utility of virtual experiments for gaining insight on systems understanding but caution is needed when using models for predictions outside the conditions for which models are calibrated.