bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methodological Frameworks and Dimensions to Be Taken Into Consideration in Digital Health Technology Assessment: Protocol for a Scoping Review
Authors: Segur-Ferrer Joan , Moltó-Puigmartí Carolina , Pastells-Peiró Roland , Vivanco-Hidalgo Rosa Maria 
Published: October 2022

Background
Health technology assessment (HTA) is one of the main tools that health systems have to appraise evidence and determine the value of a given health technology. Although the existing HTA frameworks are useful tools for the evaluation of a wide range of health technologies, more and more experts, organizations across the world, and HTA agencies are highlighting the need to update or develop specific methodological frameworks for the evaluation of digital health technologies in order to take into account additional domains that cover these technologies’ intrinsic characteristics.

Objective
The purpose of our scoping review is to identify the methodological frameworks that are used worldwide for the assessment of digital health technologies; determine what dimensions and aspects are being considered; and generate, through a thematic analysis, a proposal for a methodological framework that is based on the most frequently described dimensions in the literature.

Methods
The scoping review will be performed in accordance with the guidelines established in the updated statement of the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). We will search for peer-reviewed and grey literature published between 2011 and the date of the search execution. The retrieved references will be reviewed in a single-blind manner by 2 independent authors, and their quality will be assessed by using the Critical Appraisal Skills Program tool. The ATLAS.ti software (Scientific Software Development GmbH) will be used for data extraction and to perform the thematic analysis.

Results
The scoping review is currently (May 2022) in progress. It is expected to be completed in October 2022, and the final results of the research will be presented and published by November 2022.

Conclusions
To our knowledge, no studies have been published to date that identify the existing methodological frameworks for digital HTA, determine which dimensions must be evaluated for correct decision-making, and serve as a basis for the development of a methodological framework of reference that health care systems can use to carry out this kind of assessment. This work is intended to address this knowledge gap of key relevance for the field of HTA.

International Registered Report Identifier (IRRID)
DERR1-10.2196/39905
Formulation & Development of Baclofen microemulsion incorporated into Transdermal patch
Authors: Panghal Anshul , Sachdeva Monika , Agarwal Vijay 
Published: October 2022

The current study aims at developing formulations based on microemulsions for the transdermal patch of Baclofen. Castor oil was used in the oil phase, Tween-20 was used as a surfactant, propylene glycol(PG) worked as a cosurfactant, and water worked as an aqueous phase in the formation of microemulsions. Using Franz diffusion cells, in vitro permeation tests were conducted. At the conclusion of 8 hours, the in vitro permeation release of ME-3 was determined to be 88.79%, and baclofen microemulsion was later put into the transdermal patch. The most effective composition was ME-3, which included dimethyl sulfoxide as a penetration enhancer, propylene glycol as a plasticizer, and carbopol 940 as a bio-adhesive polymer. The formulation with the best penetration enhancement exhibited a 39-fold increase and contained 0.1% DMSO. It was discovered that ME-3 Patch has a 97.67% in vitro permeation release rate. According to a study, baclofen may be produced into transdermal patches with an acceptable appearance and an appropriate drug release time of 4 hours.
Keywords: (ME-)Microemulsion, HPMC, Transdermal patch, Baclofen, Carbopol- 940
Synthesis and Virtual Screening of Some Novel Quinazolinone Derivatives as Potent Cholinesterase Inhibitors against Alzheimer’s Disease
Authors: Kachhadiya Radhika , Prajapati Denish , Patel Krishna , Prajapati Navnit 
Published: October 2022

In the past few decades, the cholinergic theory of Alzheimer's disease has been promoted as a crucial tool for the creation of new drugs. In this study, a series of novel quinazolinone scaffold were synthesized, docked and predicted for their ADMET studies for cholinesterase inhibitors against Alzheimer’s disease. Docking study were performed, using Autodock 4.2 for the synthesized compounds 4a-c and were observed to be well accommodated in the active site of AChE compared to standard Donepezil. Compounds 4d-f were most suggested novel quinazolinone derivative that the inhibitor exhibited two hydrogen bonding interactions with AChE. In-silico drug-likeness and pharmacokinetic properties was predicted using Swiss ADME, pkCSM software. All synthesized compounds 4a-f having better pharmacokinetic profile for potential to act as a cholinesterase inhibitors against Alzheimer’s disease.
Keywords: Alzheimer’s disease, Quinazolinone, Pharmacokinetic profile, Cholinesterase, Acetylcholinesterase (AChE).
A Review on Household Poisoning and its Management
Authors: Singh S Daniel Sundar , Das Alka M , Harshini A. , Kishore Irene Mariya , Subanandhiny S.M. 
Published: October 2022

Background: Hazardous materials have become a popular home item in many developing countries over the last few decades. It has become a huge global health problem due to their simple availability, marketing, accessibility, and lack of knowledge. According to current figures, unintentional and domestic poisoning is the 13th biggest cause of mortality in India in an urban setting in India; Patil et al. (2014) identified home items to be the most common poisoning agents.
Data sources Study selection: This is a review paper. All the content in this article is taken from several reviews and guidelines published by WHO, HSRA etc.
Conclusion: To lower the prevalence of poisoning in urban settings, it is crucial to educate and raise awareness among the general public about chemical poisoning from home chemicals. Early diagnosis of suspected poisoning symptoms, implementing effective preventive measures and providing fast, focused treatment will help you win the war against poisoning in India.
Keywords: Household poisoning, WHO, Antidotes, Poison, Toxicity.
TikTok Media as an Effort to Increase Dental Health Knowledge for High School Students
Authors: RE Pudentiana Rr , Harliani Nabila Dwi , Purnama Tedi 
Published: October 2022

Background: The first step in an effort to increase knowledge and prevent dental and oral health problems is to provide counseling. The success of counseling in changing target behavior is influenced by the extension media used, one of the learning media that can be used on the internet is the TikTok application. Objective: To analyze the effectiveness of TikTok media as an effort to increase dental health knowledge among students of SMAN 1 Gunung Sindur in 2022. Methods: This study used a quasi-experimental method. This research was conducted on 32 people obtained by purposive sampling technique. The instrument used in this study was a questionnaire about oral health. Analysis of the data used is a paired sample test. Results: The results of this study showed that before being given education the average was 62.66, while after education, the average was 93.91. The results of the paired sample test obtained p value = 0.000, meaning that there is a difference in knowledge before and after dental health education with TikTok media. Conclusion: TikTok media is effective in increasing dental health knowledge in high school students.
Keywords: TikTok, Education, Dental Health
Drug-Induced Liver Injury: A Literature Review
Authors: Tandon Pooja , Malhotra Meenakshi , Singh Ajeet Pal , Singh Amar Pal , Melkani Indu 
Published: October 2022

Drug-Induced liver injury (DILI) is a common harmful drug reaction of some medication which can cause the damage to liver cells, or might be a chance of death. In the western countries DILI is the main cause for acute liver failure. These reactions are very common because almost all drug regimens can cause injury to liver. Most of DILI cases are harmless and they get better after stopping the offending drug. These reactions are mainly due to some pharmacological remedies, traditional medications, herbal and nutritional supplements. Due to these harmful reactions, elevation is noticed in the liver enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphate, total bilirubin) 2N from its normal value. Drug-induced liver injury includes 1,000 of pharmacological remedies or more. Here, we review the maximum current literature, so the treatment includes timely diagnosis and removal of the doubtable medication is the key. This paper explains the different causes, pharmacological medications responsible for drug-induced liver injury, effect of covid-19 on liver injury and future perspective. It is important to be aware of and remove the suspected agent as soon as possible. There are no specific risk factors for DILI, but existing liver disease and genetic factors may be a priority for some people. Treatment of liver damage caused by drugs and herbs includes immediate drug withdrawal and supportive care aimed at alleviating unwanted symptoms. Main purpose of this paper is to deliver the info about the DILI, which are dose related, identification and consideration of disease.
Keywords: Drug-Induced liver injury (DILI), Pathophysiology, Diagnosis, Treatment, Risk factors and effect of covid-19 on liver injury.
Ikkuna rajakarjalaismurteiden monimuotoisuuteen (tulossa)
Authors: Massinen Henna 
Published: October 2022

Henna Massisen suomen kielen alaan kuuluva väitöskirja tarkastettiin Itä-Suomen yliopistossa maanantaina 20.6.2022. Vastaväittäjänä toimi professori Riho Grünthal Helsingin yliopistosta ja kustoksena professori Marjatta Palander.
Henna Massinen: Rajakarjalaismurteiden suomalaistuminen yleisgeminaation ja itämurteiden erikoisgeminaation valossa. Joensuu: Itä-Suomen yliopisto 2022.
Kirja on luettavissa osoitteessa http://urn.fi/URN:ISBN:978-952-61-4549-5.
Nuorten aikuisten kielenhallinta ja meneillään oleva kielenmuutos
Authors: Laasanen Mikko , Pajunen Anneli , Häikiö Tuomo 
Published: October 2022

Artikkeli käsittelee kielen natiivihallintaa ja sen huomioimista sosiolingvistisessä meneillään olevan kielenmuutoksen tutkimuksessa. Artikkelissa tarkastellaan iän ja koulutuksen suhteen vertaistettujen nuorten aikuisten kielenhallintaa ja keskitytään derivaatiomorfologian hallintaan. Aineistona on yliopiston pääsykoe, jossa testattiin kielen eri osa-alueita. Pääsykokeeseen kuului derivaatiotesti, jossa piti tunnistaa mahdottomia, mahdollisia ja esiintyviä johdoksia. Kielenhallinnan arviointi perustuu pääsykokeen suoriutumistuloksiin ja ylioppilastutkinnon painotettuihin todistuspistemääriin. Tutkimuksen mukaan ylioppilaskokeen pistemäärä ennusti kokelaan suoriutumista mahdollisten johdosten tunnistuksessa tilastollisesti merkitsevästi. Laadulliseen tarkasteluun otettiin kausatiivi-, passiivi- ja teonnimijohdokset. Näiden hallinnassa havaittiin selkeää vaihtelua ja erilaisia tunnistusstrategioita. Tulosten perusteella nuorten aikuisten kielenhallinta vaihtelee, ja tällä voi olla vaikutuksia kielenmuutoksen tutkimustuloksiin. Mikäli kielenhallintaa ei tutkimuksissa kontrolloida, saatetaan yhteisölliseksi muutokseksi laskea tekijöitä, jotka todellisuudessa heijastavat kehityksellisiä tai hallinnallisia tekijöitä.

Young adults’ language proficiency and on-going language change
The article concerns native-language proficiency and its effect on the sociolinguistic study of on-going language change. The article examines the language proficiency of young adults matched for age and education, with a focus on derivational morphology. The data of the study consists of a university entrance exam assessing various aspects of linguistic knowledge. A derivation test required the subjects to recognise impossible, possible and occurring derivations. Appraisals of language proficiency are based on the results of the entrance exam in addition to the weighted scores of subjects’ matriculation examination. According to the study, the scores of the matriculation examination predicted the subjects’ success in recognising possible derivations with statistical significance. Qualitative examination of causative, passive and nominaliser derivations revealed clear variation and different recognition strategies between subjects. Based on these results, the authors suggest that young adults’ language proficiency varies and that this can affect the results of studies into on-going language change. The authors argue that if language proficiency is not sufficiently taken into account, developmental and proficiency-related factors could be mistakenly read as change on a societal level.
Efforts to Improve Japanese Language Skills of Prospective Workers at Mirai Jaya Indralaya Job Training Institute
Authors: Nariyah Nariyah , Shomedran Shomedran 
Published: October 2022

ABSTRACTThis study aims to determine the efforts to improve the Japanese language skills of prospective workers at LPK Mirai Jaya Indralaya, with a qualitative descriptive type of research. Data was collected using interview, observation and documentation methods with research subjects LPK Mirai Jaya managers, instructors, learning residents and alumni of LPK Mirai Jaya. The results obtained in this study are: 1) Internal efforts made by LPK Mirai Jaya in improving the Japanese language skills of prospective workers are going well. These efforts include education and training, as well as a learning community ability test which is carried out in accordance with the provisions of the Japan Foundation. 2) External efforts made by students at LPK Mirai Jaya to support the efforts made by LPK Mirai Jaya managers, namely the competence of learning citizens, active learning of citizens, and Japanese language skills. Keywords: Effort, Japanese language, skill
THE PERCEPTIONS OF INDONESIAN SECONDARY EFL TEACHERS CONCERNING THEIR ROLES IN SYLLABUS DESIGN
Authors: Nita Fatma Rahayu , Purwati Oikurema 
Published: October 2022

In dealing with syllabus design, teachers must recognize their roles in syllabus design since they are taking part in it. Consequently, this current study attempts to explore Indonesian secondary EFL teachers concerning their roles in syllabus design. It covers three points: their general perceptions, their boundaries, and their qualification as the EFL teacher in syllabus design. The main theory used in this study is by Nunan (2000) related to the roles in syllabus design. This study applied a qualitative approach using open-ended questionnaires and virtual interviews as the instrument of the study. A total of five respondents have participated in this current study. The results found that the teachers believe that they have a role as the implementer and designer of syllabus design. Related to their boundaries in teaching English, all teachers create and develop the syllabus based on the student's needs. Besides, it discovers that teachers are likely to have the freedom to design their activities and materials based on the student's needs even though they should follow the basic element of the syllabus provided by the authorities. Finally, the teachers still need guidance and training in syllabus design since they have a fewer understanding of syllabus design.
Impact of left ventricular ejection fraction on outcomes after left main revascularization: g-LM Registry
Authors: Daoulah Amin , Naser Maryam Jameel , Hersi Ahmad S. , Alshehri Mohammed , Garni Turki Al , Abuelatta Reda , Yousif Nooraldaem , Almahmeed Wael , Alasmari Abdulaziz , Aljohar Alwaleed , Alzahrani Badr , Abumelha Bader K. , Ghani Mohamed Ajaz , Amin Haitham , Hashmani Shahrukh , Hiremath Niranjan , Kazim Hameedullah M. , Refaat Wael , Selim Ehab , Jamjoom Ahmed , El-Sayed Osama , Al-Faifi Salem M. , Feteih Maun N. , Dahdouh Ziad , Aithal Jairam , Ibrahim Ahmed M. , Elganady Abdelmaksoud , Qutub Mohammed A. , Alama Mohamed N. , Abohasan Abdulwali , Hassan Taher , Balghith Mohammed , Hussien Adnan Fathey , Abdulhabeeb Ibrahim A.M. , Ahmad Osama , Ramadan Mohamed , Alqahtani Abdulrahman H. , Alshahrani Saif S. , Qenawi Wael , Shawky Ahmed , Ghonim Ahmed A. , Elmahrouk Ahmed , Alhamid Sameer , Maghrabi Mohamed , Haddara Mamdouh M. , Iskandar Mina , Shawky Abeer M. , Hurley William T. , Elmahrouk Youssef , Ahmed Waleed A. , Lotfi Amir 
Published: October 2022

Aims
The impact of left ventricular dysfunction on clinical outcomes following revascularization is not well established in patients with unprotected left main coronary artery disease (ULMCA). In this study, we evaluated the impact of left ventricular ejection fraction (LVEF) on clinical outcomes of patients with ULMCA requiring revascularization with percutaneous coronary intervention (PCI) compared with coronary artery bypass graft (CABG).

Methods
The details of the design, methods, end points, and relevant definitions are outlined in the Gulf Left Main Registry: a retrospective, observational study conducted between January 2015 and December 2019 across 14 centres in 3 Gulf countries. In this study, the data on patients with ULMCA who underwent revascularization through PCI or CABG were stratified by LVEF into three main subgroups; low (l-LVEF <40%), mid-range (m-LVEF 40–49%), and preserved (p-LVEF ≥50%). Primary outcomes were hospital major adverse cardiovascular and cerebrovascular events (MACCE) and mortality and follow-up MACCE and mortality.

Results
A total of 2137 patients were included; 1221 underwent PCI and 916 had CABG. During hospitalization, MACCE was significantly higher in patients with l-LVEF [(10.10%), P = 0.005] and m-LVEF [(10.80%), P = 0.009], whereas total mortality was higher in patients with m-LVEF [(7.40%), P = 0.009] and p-LVEF [(7.10%), P = 0.045] who underwent CABG. There was no mortality difference between groups in patients with l-LVEF. At a median follow-up of 15 months, there was no difference in MACCE and total mortality between patients who underwent CABG or PCI with p-LVEF and m-LVEF.

Conclusion
CABG was associated with higher in-hospital events. Hospital mortality in patients with l-LVEF was comparable between CABG and PCI. At 15 months’ follow-up, PCI could have an advantage in decreasing MACCE in patients with l-LVEF.
Urban Form and the Role of Urban Morphological Characters in Town-Plan Regionalization: A Systematic Review
Authors: Inusa Yaktor Joshua , Toe Doris Hooi Chyee , Yong Kum Weng 
Published: October 2022

Abstract
Urban morphological characters have implications for town-plan regionalization but have received little attention. This paper systematically reviewed urban form aspects, built form and morphological characters. The review highlighted built form is a reference aspect that coordinates other aspects of urban form and contains hierarchical plan-element complexes. Such complex relationship within the built form is vital to give urban form its morphological characters. Since urban morphological characters regionalize town plans, this role merits more study to establish relationships among morphological characters, town-plan regions, and sustainable development. There is also a shift to study town-plan regionalization in support of urban landscape management.
Analisis Kebutuhan Sistem Proteksi Kebakaran Sebagai Upaya Pencegahan Dan Penanggulangan Kebakaran Di Pasar Kambang
Authors: Fathul Teta Try , Fitriyani Fitriyani , Rahman Aulia 
Published: October 2022

Kebakaran pasar tradisional di Pasar Kambang terjadi 2 kali berturut-turut pada tahun 2021. Risiko kebakaran tersebut dapat dilihat dari minimnya sistem proteksi kebakaran. Penelitian ini bertujuan untuk menganalisis kebutuhan prosedur tanggap darurat, organisasi proteksi kebakaran, sumber daya manusia, alat pemadam api ringan, hidran, deteksi dan alarm kebakaran, petunjuk arah, tempat berhimpun dari sistem proteksi kebakaran di Pasar Kambang. Jenis penelitian ini adalah deskriptif kualitatif yang dilakukan dari bulan Januari - Juni 2022 di Pasar Kambang. Teknik informan dengan purposive sampling yang berjumlah 10 orang. Teknik pengumpulan data dengan wawancara, observasi dan telaah dokumen dengan triagulasi sumber dan metode. Sistem proteksi kebakaran di Pasar Kambang tidak sesuai dengan Permen PU No. 26/PRT/M/2008, Permen PU No. 20/PRT/M/2009, SNI 03-3985-2000, dan NFPA 101. Diketahui kebutuhan prosedur tanggap darurat, organisasi proteksi kebakaran, sumber daya manusia, deteksi dan alarm kebakaran, petunjuk arah sangat butuh untuk disediakan sedangkan Alat Pemadam Api Ringan di Pasar Kambang kebutuhannya sebanyak 7 buah, hidran 1 buah dan tempat berhimpun dengan ketentuan 0,3m2/orang. Sangat Butuh dibentuk prosedur tanggap darurat, organisasi proteksi kebakaran, dan peningkatan SDM, serta sangat butuh disediakan alat pemadam api ringan, hidran, deteksi dan alarm kebakaran, petunjuk arah, dan juga tempat berhimpun.
Kata Kunci : Kebutuhan, Sistem Proteksi Kebakaran, Pasar Kambang
Implementasi Algoritma Pproportional Coding pada Sistem Absensi Berbasis Barcode Menggunakan Delphi
Authors: Fauziah Fauziah , Sumiah Aah , Purnama Andri Indriana 
Published: October 2022

The development of information technology are accelerating into the various fields, so now more and more companies are trying to increase its business primarily in the areas of business that are intimately associated with the information technology itself. This is supported by the statement that the usefulness of computers in business applications is to provide information quickly and accurately. This information is like blood flowing in the body of an enterprise. If in a company, the information is stalled or blocked, then the system will become a shabby enterprise. With the computer as a data processing tool, then all areas within a company or agency may be computerized, including the use of attendance of employees in a company is one of the important things to know the performance of employees quickly and accurately. To overcome the above authors want to provide a solution by designing and applying a manual workflow attendance system into a more practical application, quickly and precisely. Therefore, the authors tried to implement it manually into the attendance system attendance system based barcode using proportionate coding algorithm as elaboration. Keywords: Proportional Coding, System, Attendance, Barcode, Delphi.