bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative Multi-Omics Analysis of Identified Ferroptosis-Marker RPL8
as a Candidate Oncogene Correlates with Poor Prognosis and Immune
Infiltration in Liver Cancer
Authors: Fan Shunli , Zhang Sai , Kong Dejun , Wang Hao , Shi Yuan , Wang Zhenglu , Zheng Hong 
Published: August 2022

Background:
Liver Hepatocellular Carcinoma (LIHC) is characterized by high malignancy,
poor prognosis, and high recurrence rate worldwide. The role of ferroptosis in tumorigenesis
and progression has been confirmed in previous studies. However, the multi-omics analysis in liver
cancer of ferroptosis-markers RPL8 remains to be elucidated.

Methods:
In this analysis, the RPL8 mRNA expression was analyzed via the GEPIA, TIMER and
UALCAN databases. In addition, we verified the mRNA expression of RPL8 by qRT-PCR experiment.
The Kaplan-Meier plotter, UALCAN, TCGAportal and HPA databases were applied to evaluate
RPL8 on prognosis and clinicopathological parameters. Moreover, we used TIMER and
Kaplan-Meier plotter to analyze the correlation of RPL8 to immune cell infiltration and immune cell
type markers to prognosis. In addition, networks and function enrichment between RPL8 coexpression
genes were analyzed by GeneMANIA, cBioportal and Metascape databases. What’s
more, we used FerrDb and GEPIA databases to analyze the correlation of 23 Ferroptosis-related
genes with RPL8.

Results:
The mRNA expression of RPL8 was over-expressed in multiple cancers. In addition, transcription
and translation levels of RPL8 in LIHC were significantly higher than normal tissues. Furthermore,
higher expression of RPL8 was closely related to shorter OS in LIHC patients. The analysis
of Kaplan-Meier plotter proved that RPL8 expression was related to stage, Sorafenib treatment,
alcohol consumption and hepatitis virus. Moreover, the results showed that the methylation expression
level of RPL8 was significantly associated with age, gender, grade, stage and TP53 mutation of
LIHC. RPL8 and its co-expression genes were primarily involved in liver regeneration and immune
system process. Immune infiltration analysis showed the RPL8 expression had positively correlated
with immune cells and immune subtypes in LIHC. Furthermore, qRT-PCR experiment validated the
expression difference of RPL8 in liver cancer.

Conclusion:
Our findings elucidated that ferroptosis-markers RPL8 may play an important role in
prognosis, and significantly correlate with ferroptosis-related genes, it also revealed the potential of
RPL8 as a novel therapeutic target for LIHC treatment and prognosis assessment.
Pharmacokinetic Study of Vadadustat and High-Resolution Mass Spectrometric
Characterization of its Novel Metabolites in Equines for the Purpose of Doping
Control
Authors: Ishii Hideaki , Shibuya Mariko , Kusano Kanichi , Sone Yu , Kamiya Takahiro , Wakuno Ai , Ito Hideki , Miyata Kenji , Sato Fumio , Kuroda Taisuke , Yamada Masayuki , Leung Gary Ngai-Wa 
Published: August 2022

Background:
Vadadustat, a hypoxia-inducible factor prolyl hydroxylase (HIF-PHD) inhibitor, is a substance
which carries a lifetime ban in both horse racing and equestrian competition. A comprehensive metabolic
study of vadadustat in horses has not been previously reported.

Objective:
Metabolism and elimination profiles of vadadustat in equine plasma and urine were studied for the purpose
of doping control.

Methods:
A nasoesophageal administration of vadadustat (3 g/day for 3 days) was conducted on three thoroughbred
mares. Potential metabolites were comprehensively detected by differential analysis of full-scan mass spectral data
obtained from both in vitro studies with liver homogenates and post-administration samples using liquid chromatography
high-resolution mass spectrometry. The identities of metabolites were further substantiated by product ion
scans. Quantification methods were developed and validated for the establishment of the excretion profiles of the
total vadadustat (free and conjugates) in plasma and urine.

Results:
A total of 23 in vivo and 14 in vitro metabolites (12 in common) were identified after comprehensive analysis.
We found that vadadustat was mainly excreted into urine as the parent drug together with some minor conjugated
metabolites. The elimination profiles of total vadadustat in post-administration plasma and urine were successfully
established by using quantification methods equipped with alkaline hydrolysis for cleavage of conjugates such as
methylated vadadustat, vadadustat glucuronide, and vadadustat glucoside.

Conclusion:
Based on our study, for effective control of the misuse or abuse of vadadustat in horses, total vadadustat
could successfully be detected for up to two weeks after administration in plasma and urine.
Myositis Associated with the Anti-COVID-19 Covishield Vaccine
Authors: Miqdadi Amal , Benmansour Nouhad , Herrag Mohammed 
Published: August 2022

Introduction:
The SARS-CoV-2 made the world stop its activities, and the only chance
of returning to normal life is the vaccine. But like any vaccination, some complications have been
reported. We report the case of a patient who presented a myositis following the administration of
the Covishield* (AZD1222, ChAdOx1 nCoV-19, AstraZeneca) Covid-19 vaccine.

Case Report:
12 hours after his first dose, an 84-year-old patient presented to us reporting a decreased muscle strength: the patient can move against gravity but not against resistance. The biological
assessment showed that CK was at 4,250 IU/L, myoglobin was at 144 microgram/L and aldolases at
16.9 U/L. The patient received high doses of corticosteroids.

Discussion:
The development of vaccines and immunization programs reduced the morbidity and
mortality of several diseases. Other case reports suggested the possible association between myopathies and the administration of the hepatitis B vaccine and H1N1 plus the seasonal trivalent influenza and other vaccines. The exact mechanism is still unknown, but a presumable autoimmune phenomenon is incriminated.

Conclusion:
The main purpose of this case report is to raise awareness about the possible link between the Covid-19 vaccination and polymyositis and the urge to take charge to avoid further complications.
Oral Squamous Cell Carcinoma Following Acute Methotrexate Toxicity in
a Psoriasis Patient: A Causal Association or Mere Co-Incidence
Authors: Choudhary Ritul , Singh Ajeet , Chhabra Namrata , Gupta Ashish Kumar 
Published: August 2022

Background:
Methotrexate is an antimetabolite anticancer drug frequently used in the
treatment of extensive chronic plaque psoriasis. Psoriasis patients on treatment with immunosuppressants
have an increased risk of developing malignancies.

Objective:
To present a rare case of Oral Squamous Cell Carcinoma (OSCC) in a psoriasis patient
postacute methotrexate toxicity.

Case Report:
A 47-year-old female, a known case of chronic plaque psoriasis for which she was on
15 mg/ week methotrexate therapy and accidentally consumed 15 mg for 7 consecutive days. She
was successfully treated for methotrexate toxicity and 45 days later she presented with exophytic
growth on the tongue. Histopathology confirmed the diagnosis of squamous cell carcinoma and the
patient underwent surgical resection.

Conclusion:
There could be a causal association between psoriasis and OSCC in the setting of acute
methotrexate toxicity, as in the present case.
Study of the Antihypertensive and Vasorelaxant Activities of Haloxylon
scoparium in Rats
Authors: Eddouks Mohamed , Amtaghri Smail 
Published: August 2022

Aims:
The work aimed to study the antihypertensive ability of Haloxylon Scoparium.

Background:
Haloxylon Scoparium Pomel is used to treat various diseases including hypertension.

Objective:
This study aimed to evaluate the antihypertensive effect of Haloxylon scoparium (H. scoparium) in hypertensive rats, and to evaluate its probable vasorelaxant activity.

Material and Methods:
The aqueous extract of Haloxylon scoparium (AEHS) was prepared and used to investigate its antihypertensive ability in L-NAME(Nω-L-arginine methyl ester)-induced hypertensive rats, and its vasorelaxant activity was studied on the isolated thoracic aorta of rats. The acute and subchronic effects of (AEHS) on blood pressure parameters were evaluated after oral administration of AEHS (60 and 100 mg/kg body weight) for 6 h for the acute experiment and for 7 days for the subchronic test.

Results:
The results indicated that AEHS decreased blood pressure parameters (systolic, mean, and diastolic blood pressure) after repeated oral administration in hypertensive rats without affecting normal rats. In addition, AEHS (375-1250 μg/mL) revealed a vasorelaxant effect in thoracic aortic rings precontracted with norepinephrine (NE) (10 µM) or KCl (80 mM). This effect was partially decreased in the presence of nifedipine, by inhibition of the vascular calcium channel pathway in isolated rat thoracic aorta.

Conclusion:
The study demonstrates the beneficial effect of Haloxylon scoparium as an antihypertensive agent. Moreover, this plant exerts vasorelaxant activity via blockade of Ca2+ channels.
Novel Applications of Graphene and its Derivatives: A Short Review
Authors: Jose Jephin K. , Jose Amal , Job Akhila , Balachandran Manoj 
Published: August 2022

Abstract:
Graphene, a layered allotropic form of graphitic carbon, has fascinated the scientific world
since its discovery. Its unique structural, physical, chemical, mechanical, and electrical properties find
application in many areas. Because of its large surface area and its apt electrical property, it is used in
electromagnetic interference shielding. With excellent carrier mobility, it is used for sensing purposes.
Mechanical strength and elastic properties coupled with its lightweight make graphene a promising
material as a supercapacitor. The 2-dimensional structural properties of the graphene layers can be
used for the purification treatment of water and gas. The number of research in graphene applications
is increasing every day, showing the importance and excellency of graphene properties. This short review
provides a comprehensive understanding of graphene's properties and progress in electromagnetic
interference shielding, sensors, water treatment, energy production, storage, and conversion applications
such as supercapacitors, fuel cells, solar cells and electrocatalysts.
Association Between COVID-19 Pandemic and Serious Mental Illness: Systematic Review within Salutogenesis Model for Public Health Management
Authors: Kaman Sweta , Sharma Ankita , Banerjee Romi 
Published: August 2022

Background:The outbreak of the COVID-19 pandemic, the constant transformation of the SARS-COV-2 virus form, exposure to substantial psychosocial stress, environmental change, and isolation have led to the inference that the overall population's mental health could be affected, resulting in an increase in cases of psychosis.Objective:We initiated a systematic review to determine the impact of the SARS-COV-2 virus and its long-term effects - in both symptomatic and asymptomatic cases - on people with or without psychosis. We envisioned that this would give us an insight into effective clinical intervention methods for patients with psychosis during and after the pandemic.Method:We selected fifteen papers that met our inclusion criteria, i.e., those that considered participants with or without psychiatric illness and exposed to SARS-COV-2 infection, for this review and were retrieved via Google, Google Scholar, MEDLINE, PubMed, and PsychINFO Database.Key Gap:There is a dearth of research in understanding how COVID-19 affects people with or without a prior personal history of psychosis.Results:The systematic review summary provides insight into the state of knowledge. Insights from the systematic review have also been reviewed from the salutogenesis model's perspective. There is moderate evidence of new-onset psychosis during the COVID-19 pandemic in which some antipsychotics treated the psychotic symptoms of patients while treating for COVID-19. Suggestions and recommendations are made for preventive and promotive public health strategies.Conclusion:The Salutogenesis model and Positive Psychology Interventions (PPI) provide another preventive and promotive public health management approach.
Literature Review on Development of Feature Selection and Learning
Mechanism for Fuzzy Rule-Based System
Authors: Kumar Ankur , Kaur Avinash 
Published: August 2022

Abstract:
This research is being conducted to study fuzzy system with improved rule base. Rule base is an important part of any fuzzy inference system designed. Rules of a fuzzy system depend on the number of features selected. Selecting an optimized number of features is called feature selection. All features (parameters) play an important role in the input to the system, but they have a different impact on the system performance. Some features do not even have a positive impact of classifier on multiple classes. Reduced features, depending on the objective to be achieved require fewer training rules, Thereby, improving the accuracy of the system. Learning is an important mechanism to automate fuzzy systems. The overall purpose of the research is to design a general fuzzy expert system with improvements in the relationship between interpretability and accuracy by improving the feature selection and learning mechanism processes through nature-inspired techniques or innovating new methodologies for the same.
Social Media Impact of Articles Published by Dermatology Residents During Medical School: Cross-sectional Study
Authors: Huang Austin , Zhu Harrison , Zhou Kelvin , Kirby R Parker , Dasari Nina , Calderara Gianmarco A , Cordova Kathryn , Sorensen Ryan , Bhatnagar Anshul , Kim Soo Jung 
Published: August 2022

Background
The Altmetric score (AS) is a novel measure of publication impact that is calculated by the number of mentions across various social media websites. This method may have advantages over traditional bibliometrics in the context of research by medical students.

Objective
This study aimed to determine whether dermatology matriculants who graduated from higher-ranked medical schools published more articles with greater impact (ie, a higher AS) than those from lower-ranked institutions.

Methods
A PubMed search for articles published by dermatology residents who started medical school in 2020 was conducted. Demographic information and Altmetric data were collected, and medical schools were sorted according to US News’ top-25 and non–top-25 categories.

Results
Residents who completed their medical training at a top-25 institution published more papers (mean 4.93, SD 4.18 vs mean 3.11, SD 3.32; P<.001) and accrued a significantly higher total AS (mean 67.9, SD 160 vs mean 22.9, SD 75.9; P<.001) and average AS (mean 13.1, SD 23.7 vs mean 6.71, SD 32.3; P<.001) per article than those who graduated from non–top-25 schools.

Conclusions
Our results indicate that students in top-25 schools may have greater access to research resources and opportunities. With a pass/fail United States Medical Licensing Examination Step 1 exam that may increasingly shift focus toward scholarly output from medical students, further discussion on how to create a more equitable dermatology match is essential.
An Evaluation of Primary Studies Published in Predatory Journals Included in Systematic Reviews From High-Impact Dermatology Journals: Cross-sectional Study
Authors: Ottwell Ryan , Hightower Brooke , Failla Olivia , Snider Kelsey , Corcoran Adam , Hartwell Micah , Vassar Matt 
Published: August 2022

Background
Predatory publishing is a deceptive form of publishing that uses unethical business practices, minimal to no peer review processes, or limited editorial oversight to publish articles. It may be problematic to our highest standard of scientific evidence—systematic reviews—through the inclusion of poor-quality and unusable data, which could mislead results, challenge outcomes, and undermine confidence. Thus, there is a growing concern surrounding the effects predatory publishing may have on scientific research and clinical decision-making.

Objective
The objective of this study was to evaluate whether systematic reviews published in top dermatology journals contain primary studies published in suspected predatory journals (SPJs).

Methods
We searched PubMed for systematic reviews published in the top five dermatology journals (determined by 5-year h-indices) between January 1, 2019, and May 24, 2021. Primary studies were extracted from each systematic review, and the publishing journal of these primary studies was cross-referenced using Beall’s List and the Directory of Open Access Journals. Screening and data extraction were performed in a masked, duplicate fashion. We performed chi-square tests to determine possible associations between a systematic review’s inclusion of a primary study published in a SPJ and particular study characteristics.

Results
Our randomized sample included 100 systematic reviews, of which 31 (31%) were found to contain a primary study published in a SPJ. Of the top five dermatology journals, the Journal of the American Academy of Dermatology had the most systematic reviews containing a primary study published in an SPJ. Systematic reviews containing a meta-analysis or registered protocol were significantly less likely to contain a primary study published in a SPJ. No statistically significant associations were found between other study characteristics.

Conclusions
Studies published in SPJs are commonly included as primary studies in systematic reviews published in high-impact dermatology journals. Future research is needed to investigate the effects of including suspected predatory publications in scientific research.
Associations Between Depression Symptom Severity and Daily-Life Gait Characteristics Derived From Long-Term Acceleration Signals in Real-World Settings: Retrospective Analysis
Authors: Zhang Yuezhou , Folarin Amos A , Sun Shaoxiong , Cummins Nicholas , Vairavan Srinivasan , Qian Linglong , Ranjan Yatharth , Rashid Zulqarnain , Conde Pauline , Stewart Callum , Laiou Petroula , Sankesara Heet , Matcham Faith , White Katie M , Oetzmann Carolin , Ivan Alina , Lamers Femke , Siddi Sara , Simblett Sara , Rintala Aki , Mohr David C , Myin-Germeys Inez , Wykes Til , Haro Josep Maria , Penninx Brenda W J H , Narayan Vaibhav A , Annas Peter , Hotopf Matthew , Dobson Richard J B ,   RADAR-CNS Consortium
Published: August 2022

Background
Gait is an essential manifestation of depression. However, the gait characteristics of daily walking and their relationships with depression have yet to be fully explored.

Objective
The aim of this study was to explore associations between depression symptom severity and daily-life gait characteristics derived from acceleration signals in real-world settings.

Methods
We used two ambulatory data sets (N=71 and N=215) with acceleration signals collected by wearable devices and mobile phones, respectively. We extracted 12 daily-life gait features to describe the distribution and variance of gait cadence and force over a long-term period. Spearman coefficients and linear mixed-effects models were used to explore the associations between daily-life gait features and depression symptom severity measured by the 15-item Geriatric Depression Scale (GDS-15) and 8-item Patient Health Questionnaire (PHQ-8) self-reported questionnaires. The likelihood-ratio (LR) test was used to test whether daily-life gait features could provide additional information relative to the laboratory gait features.

Results
Higher depression symptom severity was significantly associated with lower gait cadence of high-performance walking (segments with faster walking speed) over a long-term period in both data sets. The linear regression model with long-term daily-life gait features (R2=0.30) fitted depression scores significantly better (LR test P=.001) than the model with only laboratory gait features (R2=0.06).

Conclusions
This study indicated that the significant links between daily-life walking characteristics and depression symptom severity could be captured by both wearable devices and mobile phones. The daily-life gait patterns could provide additional information for predicting depression symptom severity relative to laboratory walking. These findings may contribute to developing clinical tools to remotely monitor mental health in real-world settings.
Caminar en fantasía: lo liso, el cuento de hadas y la nómada en Eggshells de Caitriona Lally
Authors: Ulloa Carolina 
Published: August 2022

Con base en el concepto nómada de Gilles Deleuze y Félix Guattari, una figura propia de su teoría sobre el espacio liso, en este artículo estudio las caminatas de Vivian Lawlor, protagonista de la novela Eggshells (2014) de Caitriona Lally. Mientras que Dublín funge como la contraposición del espacio liso ¾el espacio estriado¾, Vivian, por su manera de estar y relacionarse con el espacio (Deleuze y Guattari), encarna a la nómada al reterritorializar la ciudad. En el nivel diegético, esta protagonista ¾mujer, desempleada, que vive de la seguridad social, sin hijos y que no cuida su apariencia¾ resignifica la capital de Irlanda a partir de su creencia de que es un changeling, un hada de la tradición folclórica de la nación, y de que la recorre a pie para encontrar portales que la transporten a su supuesto lugar originario. Esta certeza surge de las violencias físicas y emocionales que se ejercieron sobre ella durante la infancia por el rechazo de sus padres. Al mismo tiempo, el caminar de Vivian resulta en un posicionamiento frente a su identidad como Otra, lo cual tiene un impacto en el nivel extradiegético. De esta forma, los desplazamientos de la protagonista no sólo son literales, sino metafóricos: sus andanzas se vuelven una confrontación de estándares de feminidad que, en este caso, son representativos del espacio estriado. Para demostrar que estas caminatas ocurren en los niveles ya referidos, analizo la manera de Lally de apropiarse de las características del cuento de hadas como aquello que funda la condición nómada de Vivian.
México en el multilateralismo ginebrino, un balance historiográfico
Authors: Toledo García Itzel 
Published: August 2022

Este artículo analiza la historiografía de la actividad diplomática mexicana en la Sociedad de Naciones (SDN). Se presenta un recuento de los estudios de tres cuestiones: la exclusión e ingreso de México a la SDN de 1919 a 1931, su paulatina colaboración con los organismos técnicos en los años veinte y su activa participación frente a problemas internacionales de los años treinta como invasiones y conflictos bélicos. Mientras que en el siglo XX se prestó poca atención a estas cuestiones, este artículo muestra que en el siglo XXI ha surgido un cuerpo sólido de estudios especializados sobre el posicionamiento mexicano frente a problemas internacionales, principalmente respecto a la defensa de la República Española.