bluuebunny/crossref_metadata_2025_split huggingface dataset:
Splenic lymphangiomas as a common indication for splenectomy: a case series with literature review
Authors: Efared Boubacar , Bako Aïchatou Balaraba Abani , Younssa Hama , Boubacar Idrissa , Zabeirou Aliou , Koura Hamadou Halidou , Boureima Habiba Salifou , Amadou Soumaila , Coulibaly Idrissa Seriba , Lassey James Didier , Nouhou Hassan 
Published: September 2022

Abstract
Background
Splenic lymphangiomas (SL) are very rare benign cystic lesions found in pediatric population. Their occurrence in adults is exceptional. Splenectomy is the common management of splenic lesions for diagnostic and/or therapeutic purpose. Our aim is to report additional cases of SL diagnosed on splenectomy specimens at our Pathology laboratory with literature review.
Methods
This is a retrospective study including all cases of splenectomy recorded at our Pathology laboratory (June 2020 – August 2022). We performed a comparison of clinicopathological features between patients with SL and those with other benign splenic diseases.
Results
Sixteen cases of splenectomy were included. The mean age was 30.25 years (range of 6–70 years). The final histopathological diagnoses were congestive spleens in all cases of sickle cell disease (SCD) (5/16 patients, 31.25%), splenic cystic lymphangiomas (4/16 patients, 25%), capsular splenic infiltration by gastric and colic cancers (3/16 cases, 18.75%), splenic abscess (2/16 cases, 12.5%) and splenic rupture with subcapsular hematoma (1/16 patients ,6.25%). 12/16 patients (75%) had benign splenic conditions (4/12 with SL, 5/12 with SCD, 2/12 with abscess and 1/12 with splenic trauma). Patients with SL were older than those with other benign splenic conditions (mean age of 28.27 years versus 20.87 years). Also patients with SL presented with massive splenomegaly (mean splenic weight of 1675 g versus 418.75 g, mean splenic size of 19.62 cm versus 14.63 cm). Open surgery was performed in 15/16 patients (93.75%).
Conclusions
Unlike previous studies, our series shows that SL are a common indication for splenectomy and occur in older patients with massive cystic splenomegaly. Open splenectomy is still an usual surgical practice in our country.
Pregnancy Outcomes of Women with a Third Parity in Southwest China
Authors: Yao Junxiu , Guo Xin , Dong Xudong 
Published: September 2022

Abstract
Background: Fertility is a topic of concern in every country, and all the countries are advocating fertility and improving their fertility policies. The aim of this study was to investigate the effects of parity on pregnancy outcomes, and provided reasonable prevention and intervention of risk factors to reduce the incidence of adverse maternal and infant pregnancy outcomes.
Methods: A total of 1,200 women were randomly selected by parity and they were divided into three groups. The pregnancy outcomes of the three groups were compared by using Partition of Chi-square. Logistic regression was conducted to estimate the association between parity and pregnancy outcomes after adjusting for other confounding influencing factors.
Results: Age (28.82 ± 4.01 vs 32.33 ± 4.30 vs 33.80 ± 4.49), BMI (26.31 ± 3.04 vs 27.08 ± 3.17 vs 27.57 ± 3.36), gestational weeks (39.13 ± 1.67 vs 38.70 ± 1.71 vs 38.36 ± 1.82), days from admission to delivery (0.89 ± 1.20 vs 0.89 ± 1.28 vs 1.13 ± 1.18), scar uterus (0.8% vs 37% vs 62%), fertilization way, and delivery way were significantly different among the three groups of women. Multi parity is a risk factor for the occurrence of preterm birth (OR = 1.602, 95% CI: 1.181–2.173), perinatal anemia (OR = 1.468, 95% CI: 1.099–1.963), and uterine rupture (OR = 2.752, 95% CI: 1.261–6.007). It is a protective factor for low birth weight (OR = 0.564, 95% CI: 0.321–0.992), amniotic fluid turbidity (OR = 0.556, 95% CI: 0.418–0.739), and fetal distress (OR = 0.171, 95% CI: 0.080–0.365) (P < 0.05).
Conclusion: Multi parity is not an independent risk factor for adverse pregnancy outcomes, but mostly combined with scar uterus, advanced age, obesity, IVF, and other risk factors that lead to adverse pregnancy outcomes. Strictly controlling the indications of cesarean section, early fertility, and reasonable weight gain during pregnancy are the most effective measures to prevent adverse pregnancy outcomes after the opening of the three-child policy in China.
Over-expression of a cinnamyl alcohol dehydrogenase-coding gene, GsCAD1, from wild soybean enhances resistance to soybean mosaic virus
Authors: xun hong wei , Qian Xueyan , Wang Meng , Yu Jiaxin , Zhang Xue , Pang Jinsong , Wang Shucai , Jiang Lili , Dong Yingshan , Liu Bao 
Published: September 2022

Abstract
Soybean mosaic virus (SMV) is the most prevalent soybean viral disease around the world. As a critical enzyme in secondary metabolism of plants, especially in lignin synthesis, cinnamyl alcohol dehydrogenase (CAD) is widely involved in plant growth and development, and defense pathogen infestation. We performed transcriptome analyses between a high SMV-resistant accession (BYO-15) of wild soybean (Glycine soja) and a SMV-susceptible soybean cultivar (Williams 82) at 7 and 14 days post-inoculation with SMV, found that the expression of GsCAD1 was significantly up-regulated after the inoculation with SMV in the wild soybean, while the GmCAD1 did not show a significant and persistent induction in the soybean cultivar, suggesting GsCAD1 might play a role in SMV resistance. We cloned GsCAD1 and overexpressed it in a SMV-susceptible cultivar Williams 82, we found that two independent GsCAD1-overexpression (OE) lines showed significantly enhanced SMV resistance compared with the non-transformed wild-type (WT) control. Intriguingly, the lignin content in both OE lines were higher than the WT control. Further liquid chromatography (HPLC) analysis showed that the contents of Salicylic Acid (SA) were significantly improved in the OE lines than that of WT, coinciding with the up-regulated expression of an SA synthesis and response gene, PR1. Finally, we observed that either or both replication and intercellular movement of SMV in leaves of the transgenic GsCAD1-OE lines were constrained relative those in non-transgenic WT plants. Collectively, our results suggest that GsCAD1 enhances resistance to SMV in soybean most likely by affecting the contents of lignin and SA.
Three-decadal biomonitoring highlight the critical role of land buffer area in wetland biodiversity conservation
Authors: Zhang Yan , Huang Daizhong , Jin Xiaowei , Li Liqiang , Wang Chouming , Wang Yeyao , Pellissie Loïc , Johnson Andrew , Wu Fengchang , Zhang Xiaowei 
Published: September 2022

Abstract
Ecosystems on earth have endured rapid changes over the last decades, but freshwater wetlands have disproportionally suffered biodiversity loss. Understanding the drivers of the decline of wetland ecosystems is the prerequisites for effective management scheme. However, a lack of long-term data on biological indicators like benthic macroinvertebrates have limited our understanding. Under the critical time window of the recent Anthropocene, China's longest in-situ aquatic biomonitoring data were combined with satellite imaging to construct profiles of some essential biodiversity variables of the Dongting Lake, a large Ramsar wetland in the Yangtze River basin. The results showed that the integrity of macroinvertebrate community systematically declined in the last three decades, accompanied by the stresses of lake eutrophication, climate warming and weakening of the connectivity between the Yangtze River and the lake. Unlike previously speculated attribution, the establishment of the Three Gorges Dam was found to only have a limited impact on the biodiversity loss of Dongting Lake. Changes in human land-use intensity in the surrounding terrestrial ecosystem, by increasing nutrient loading, were found to be the main mechanism resulting in the decline of macroinvertebrates. Biodiversity changes were most influenced by land-use within 1.5 km from the water body. The results highlight that to attenuate such a major local land-use effect, establishing a protected buffer area surrounding wetland ecosystems will help preserve biodiversity in the future.
A phase II study of chidamide, cytarabine, aclarubicin, granulocyte colony-stimulating factor, and donor lymphocyte infusion for relapsed acute myeloid leukemia and myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation
Authors: Wei Yan , Wang Lijun , Zhu Chengying , Li Honghua , Bo Jian , Zhang Ran , Lu Ning , Wu Yongli , Gao Xiaoning , Dou Liping , Liu Daihong , Gao Chunji 
Published: September 2022

Abstract
Chemotherapy followed by donor lymphocyte infusion (DLI) is a promising treatment for relapsed acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the best strategy for administering this therapy is still unclear. This study sought to explore the efficacy and safety of chidamide and CAG (cytarabine, aclarubicin and granulocyte colony-stimulating factor) (CCAG) regimen followed by DLI in relapsed AML/MDS after allo-HSCT. This was a single-arm, phase II trial in patients with relapsed AML/MDS after allo-HSCT. CCAG regimen followed by DLI was given according to the inclusion and exclusion criteria. Twenty adult patients were enrolled. The median follow-up time was 12 months. The complete remission (CR) rate was 45% and the partial remission (PR) rate was 5%. The 1-year overall survival (OS) was 56.7% (95% confidence interval (95% CI), 31.6-75.6%), and the median OS was 19 months. The one-year disease-free survival (DFS) was 83.3% (95% CI, 27.3-97.5%). Patients relapsing more than 6 months after HSCT and achieving CR/PR after CCAG plus DLI regimen attained significantly higher survival rates. The cumulative incidence of grade III-IV acute graft-versus-host disease (aGVHD) was 9.4%. There was no treatment-related mortality (TRM). These data suggest that CCAG plus DLI regimen is safe and induces durable remission and superior survival in patients with relapsed AML/MDS after allo-HSCT. Trial registration number: ChiCTR.org identifier: ChiCTR1800017740 and date of registration: August 12, 2018.
Evaluation of the relationship between the occlusal vertical dimension and temporomandibular joint disorders
Authors: Demir Azize , Röhlig Bilge Gökçen , Keskin Z. Haluk 
Published: September 2022

Abstract
Objectives: This study was devised to assess the relationships between the Turkish population's occlusal vertical dimension and temporomandibular disorders (TMD).
Materials and Methods: This study evaluated the questionnaire forms and clinical examination results of 114 individuals who had applied to the clinic and accepted the inclusion criteria. Diagnostic Criteria/Temporomandibular Disorders (DC/TMD) forms were filled up for each patient. Clinical examinations were performed with the help of the DC/TMD Clinical Examination Form and finalized with an extraoral examination. An extensive statistical analysis was conducted, and the results were evaluated as p < 0.05.
Results: This study demonstrated that the occlusal vertical dimension is low in 35.09% of the individuals and high in 18.42% of individuals living in Turkish society. The vertical dimension proved to be significantly related to depression (p = 0.035) and the cause of the movement pain (p = 0.02). However, the relationship between the occlusal vertical dimension and TMD disorders was not statistically significant (p < 0.05).
Conclusions: In contrast to the typical expectations, there is no relationship between the occlusal vertical dimension and TMD. No statistically significant relationship was found between the vertical dimension and the tooth wear. It appears to be that the dentoalveolar compensation theory can explain this.
Clinical Relevance: Since the tooth wear affects the degeneration of the temporomandibular joints, all clinicians making clinical examinations should be well informed about the relation between tooth wear and TMD.
NCAPD2 Is a Favorable Predictor of Prognostic and Immunotherapeutic Biomarker for Multiple Cancer Types Including Lung Cancer
Authors: Feng Linyuan , Yang Yang , Lin Zhenhua , Cui Minghua , Jin Aihua , Cui Aili 
Published: September 2022

Abstract
Background: Non-SMC condensin I complex subunit D2 (NCAPD2) belongs to the chromosomal structural maintenance family. While the different contribution of NCAPD2 to chromosome in mitosis have been thoroughly investigated, much less is known about the expression of NCAPD2 in pan-cancer. Thus, we used a bioinformatics dataset to conduct a pan-cancer analysis of NCAPD2 to determine its regulatory role in tumors.
Methods: Multiple online databases were analyzed NCAPD2 gene expression, protein level, patient survival and functional enrichment in pan-cancer. Genetic alteration and tumor stemness of NCAPD2 were analyzed using cBioPortal and SangerBox. The GSCA and CellMiner were used to explore the relationship between NCAPD2 and drug sensitivity. The diagnostic value of prognosis was evaluated by ROC curve. Subsequently, the immuneinfiltration level and immune subtype of NCAPD2 in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) were analyzed using TIMER1 and TISIDB.
Results: NCAPD2 gene expression was significantly higher in most cancers and associated with clinical stage and poor prognosis. Genomic heterogeneity of NCAPD2 promoted the occurrence and development of tumors. GO enrichment analysis suggested NCAPD2 might be involved in DNA repair and immune response. NCAPD2 was involved in immune infiltration of LUAD and LUSC. ROC curves showed that NCAPD2 has important prognosis diagnostic value in LUAD and LUSC. Moreover, NCAPD2 was drug sensitive to topotecan, which may be an optimize immunotherapy.
Conclusions: It was found that NCAPD2 was overexpressed in pan-cancers, which was associated with poor outcomes. Importantly, NCAPD2 could be a diagnosticmarker and an immune related biomarker for LUAD and LUSC.
Induction of somatic embryogenesis and plantlet regeneration in Areca concinna, an endangered palm species
Authors: Veluru Aparna , Mohammed Neema Scientist , Shil Sandip Senior Scientist , Prakash Krishna , Kotian Kavya , KS Muralikrishna , Karun Anitha 
Published: September 2022

Abstract
Areca concinna (Arecaceae) is an endangered plant species endemic to south western Sri Lanka. The palm was listed as endangered plant species by IUCN due to habitat loss; hence a multiplication and conservation strategy needs to be accorded. Here at ICAR CPCRI, a protocol was developed for clonal propagation of A. concinna. The explants, immature inflorescence, immature and mature zygotic embryos were tested for callogenesis and subsequent somatic embryogenesis in M72 basal media supplemented with the auxins 2, 4-D and Picloram. Of the three types of explants inoculated, somatic embryogenesis was observed only from mature zygotic embryos. The auxin 2, 4-D enhanced callus multiplication and somatic embryogenesis when compared to picloram. Somatic embryos grown in Y3 or 1/2 Y3 basal medium supplemented with BAP (1 mg/L), NAA (0.5 mg/L), and IBA (0.25 mg/L) developed into plantlets. This protocol has its application in the rapid multiplication of A. concinna palms thereby enhancing the possibility of conservation of the endangered palm.
Corticotropin stimulated steroid profiles to predict shock development and mortality in sepsis: From the HYPRESS study
Authors: Briegel Josef , Möhnle Patrick , Keh Didier , Lindner Johanna M. , Vetter Anna C. , Bogatsch Holger , Lange Dorothea , Frank Sandra , Hinske Ludwig C. , Annane Djillali , Vogeser Michael 
Published: September 2022

Abstract
Rationale: Steroid profiles combined with the corticotropin stimulation test can be used to obtain a more complete picture of adrenocortical function in critically ill patients.
Objectives: Our objective was to investigate whether steroid profiles before and after corticotropin stimulation predict shock development and mortality in human sepsis.
Methods: An exploratory data analysis of a double-blind, randomized trial in sepsis (HYPRESS [Hydrocortisone for the PRevention of Septic Shock]) was performed. The trial included adult patients with sepsis who were not in shock and were randomly assigned to placebo or hydrocortisone treatment (200 mg for 5 days). Corticotropin tests were performed in 206 patients before randomization and in 20 healthy subjects. Samples were analyzed using the multi-analyte stable isotope dilution method (LC-MS/MS) for steroid profiling. Steroid profiles of healthy subjects undergoing corticotropin tests served as controls to determine reference ranges.
Measurements and Main Results: Corticotropin test samples from 180 patients and 20 volunteers were included. Compared to healthy subjects, patients with sepsis had elevated levels of 11-desoxycorticosterone and 11-desoxycortisol, consistent with activation of both glucocorticoid and mineralocorticoid pathways before stimulation. After stimulation with corticotropin, the cortisol response was subnormal in 12% and the corticosterone response in 50% of sepsis patients. A predominance of glucocorticoids over mineralocorticoids after corticotropin stimulation (cortisol-corticosterone ratio > 32.2) predicted the development of shock within 14 days and death within 90 days in the placebo group.
Conclusions: In this exploratory data analysis, corticotropin stimulated cortisol-to-corticosterone ratio served as a criterion to predict shock development and mortality in sepsis.
Clinical trial registered with www.clinicaltrials.gov Identifier: NCT00670254. Registered 1 May 2008.
ncRNAs-mediated high expression of CDCA7L favors the prognosis of uveal melanoma and is associated with an immune checkpoint PD1
Authors: Wei Xixiang , Yang Hui , Fu Zheng , Yin Xue , Xiong Weiwei 
Published: September 2022

Abstract
Uveal melanoma (UVM) is the most common primary malignant tumor in adults and seriously threatens patients' eyesight and life. More and more evidence shows that the CDCA7L gene plays a crucial role in the occurrence and development of several human cancers. However, the specific part and mechanism of CDCA7L in UVM have not been completely determined. In this study, we first analyzed the expression and prognosis of CDCA7L by using the Cancer Genome Map (TCGA) data and Genotype-Tissue Expression (GTEx). We found that the expression of CDCA7L was beneficial to the prognosis of UVM. Subsequently, non-coding RNA related to CDCA7L was identified through computer analyses, including expression analysis, correlation analysis, and survival analysis. Finally, LRRC75A-AS1 and SNHG1/hsa-miR-199a-5p/ CDCA7L axes were identified as the most potential upstream ncRNA-related pathways of UVM CDCA7L. In addition, the level of CDCA7L was negatively correlated with the expression of PD1 in the immune checkpoint. Our findings clarify that the up-regulation of CDCA7L mediated by ncRNAs in UVM benefits tumor prognosis and is related to immune checkpoint PD1.
An architecture for continuous deployment of the Smart Collaborative Learning Service (SCLS) based on a predictive model to build complementary teams
Authors: Akhrif Ouidad , Benfares Chaymae , Idrissi Younès El Bouzekri El , Hmina Nabil 
Published: September 2022

Abstract

In this article, we tried to present a novel opportunity of sharing knowledge between teams of learners based on the completeness of their skills. We then, produced an intelligent collaborative learning service for the prediction of complementary teams that participate in a pedagogical method of sharing and acquiring knowledge within the academic environment. This smart service encapsulates a predictive model that is selected dynamically basing on its higher accuracy to achieve a continuous and high-performance result concerning team’s composition. Precisely, we covered the Smart Collaborative Learning service deployment in a cloud architecture (Amazon Web Service) to provide continuous and on-demand building complementary team service through their REST API interface. This experimentation led us to design a new architecture allowing the continuous deployment of a predictive model in a cloud environment while using streaming and integrated deployment architectures. We proposed a novel cloud architecture for continuously deploying a Smart Collaborative Learning Service that encapsulates a predictive model for building complementary teams of learners. Invocating this smart service in a collaborative learning platform creates a flexible building team of learners, based on the completeness of learner skills required by a collaborative project. This intelligent service meets the intelligence criteria that we cited in our approach to assess its ability to continuously respond to environmental changes and data updates, to effectively predict complementary teams. In the present work, we successfully deployed the intelligent collaborative learning service and make it powerful and on-demand sharing using its REST API. Thanks to the proposed architecture which includes intelligent layers from the semantic representation of the data, heuristic preprocessing, the development of predictive models and the streaming of data updates.
A New Approach to Remove Anionic Dye from Aqueous Solutions: Encapsulation Triggered by Ionotropic Gelation of CMC
Authors: Alver Erol , Doğan Deniz , Mert Humeyra , Metin Ayşegül Ülkü 
Published: September 2022

Abstract
In the present study, encapsulation was used as an efficient
and rapid removal method for RB-250 from aqueous solutions. This
technique involves the simultaneous formation of CMC particles and
the entrapment of the anionic dye RB-250 within these particles.
TEM and Zeta analyses of dye encapsulated CMC particles showed
needle type agglomeration of particles. Various parameters were
investigated to optimize the RB-250 removal efficiency of CMC by
encapsulation. These studies revealed that temperature, pH, time
and stirring rate have negligible effect on the encapsulation of
RB-250. It is quite remarkable that pH, which is a parameter that
significantly affects the removal efficiency in the removal of
charged dyes, has a negligible effect in the proposed technique.
RB-250 encapsulation capacity of CMC nanoparticles was determined
as 2809 mg RB-250/g CMC.
4D Interpretation of time-lapse electrical resistivity monitoring data to identify preferential flow paths in an uncontrolled landfill, South Korea
Authors: Song Seo Young , Kim Bitnarae , Jeong Juyeon , Park Samgyu , Nam Myung Jin 
Published: September 2022

Abstract

Monitoring leakage of leachate from a landfill is critical in preventing possible contamination into the surrounding area. Among geophysical surveys, time-lapse (TL) electrical resistivity tomography (ERT) has been performed along eleven survey lines at four different time points in a landfill in Korea. The TL data sets were interpreted using an in-house 4D inversion algorithm. Changes in 4D inversion results were analyzed in order to detect leachate-contaminant region. Since a rainy season started during obtaining TL ERT data sets, effects of precipitation on TL ERT data are also analyzed. Changes in electrical resistivity (ER) showed that precipitation increases ER of contaminant zones. As hydrogeochemical data are helpful to interpret ERT inversion, we also classified soil textures from particle size analysis on soil samples obtained from observation wells in the survey site. The information of soil structure as well as the results of 4D inversion offered appropriate interpretation of preferential flow path.