bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptions and experiences of dialysis nurses regarding redeployment to other dialysis units during the COVID-19 pandemic
Authors: Zimbudzi Edward , Fraginal Denise 
Published: September 2022

AbstractIntroductionRedeployment of healthcare workers is one of the strategies that has been successfully used to manage increased workload and shortage of staff during the COVID-19 pandemic. However, little is known about how best to do this in the pandemic and beyond.ObjectiveUsing experiences from a large metropolitan teaching hospital in southeast Melbourne, Australia, this qualitative study sought to understand and describe the experiences and perspectives of dialysis nurses who were redeployed across five hemodialysis units affiliated to this hospital during the COVID-19 pandemic.MethodSixteen interviews were conducted in March 2022 among nurses who had been redeployed to other dialysis units during the COVID-19 pandemic. Maximal variation sampling was used to ensure an even representation with regards to gender, dialysis nursing experience and primary place of work. Discussions were audiotaped and transcribed verbatim and inductive thematic analysis was performed.ResultsOf the participants interviewed, most were females (75%) and at least 50% were aged 36-45 years. A majority of the participants (56%) had less than 5 years of dialysis nursing experience and 70% had been redeployed to other dialysis units on at least five occasions. Five main themes emerged. These were the nurses’ immediate reaction, barriers to redeployment, benefits of redeployment, local and organisational support and opportunities for improvement.ConclusionRedeployment of nurses across different dialysis units is associated with personal and organisational benefits. However, there are a number of barriers that need to be addressed to improve the experience of redeployed nurses.
Perception and action in unimodal and crossmodal illusions: Towards a resolution of a long-standing debate in behavioural cognitive neuroscience
Authors: Bruno Nicola , Uccelli Stefano 
Published: September 2022

Abstract
Behavioral perception-action dissociations are widely used to test models of high-level vision1,2, but debates concerning their interpretation have neglected a key issue. Environmental determinants of behavior are fundamentally multisensory3, and sensorimotor tasks can engage multisensory processing in fundamentally different ways in comparison to perceptual tasks. To test this idea, we compared perception and action with a well-understood size-contrast illusion, manipulating both unimodal and crossmodal stimulation as well conditions that are known to favor or hinder multisensory integration. Results demonstrate that varying such conditions can cause a visual task to be affected by the illusion, or remain fully unaffected, whereas a visuomotor task can be affected by the illusion, remain immune from the illusion, or, unexpectedly, even show a robust reverse effect. Thus, similar or dissociable effects on perception and action can be observed depending on factors that are known to affect multisensory processing. These findings provide a novel perspective on a long standing debate in behavioral cognitive neuroscience.
Cassava Root Cortex Peroxidase (CCP) as a Potential Alternative Source of Peroxidase
Authors: Sornwatana Thakorn , Rotchanapreeda Tiwa , Wongsamart Rungdawan , Mongkol Nadtaya , Somana Jamorn 
Published: September 2022

Abstract
Cassava is one of the most important starch crops in the world. Cassava starch factories normally generate a huge amount of cassava tuberous root residual which is usually discarded and might cause pollution to the environment. In order to find some extra benefits of such waste, in this study, cassava root cortex peroxidase (CCP) was found up to 20 mg/kg fresh deteriorated cortex tissue from tuberous root and also able to demonstrate some applications similar to horseradish peroxidase (HRP). The characterization revealed that major native CCP was a 105-kDa dimeric peroxidase with two 54-kDa monomers. Using 3,3′-diaminobenzidine (DAB) as substrate in the assay, CCP was found to be tolerant and could maintain its activity in a wide temperature range from 20 to 70°C with an optimum at 65°C. CCP was stable in board pH range from 3 to 11 with maximum activity at pH 5.0. Despite simple purification with ammonium sulfate precipitation, partial purified CCP was capable of determining glucose concentrations with glucose oxidase as similar capability as horseradish peroxidase (HRP). For application as reporter enzyme in immunoassays, the self-made secondary antibody conjugated with CCP did successfully detect the protein antigen in Western blot analysis using the luminol as chemiluminescent substrate. These demonstrations indicated CCP as one of the most robust peroxidases. Moreover, the active enzyme could be easily retrieved from the industrial waste of cassava peel at low cost. Further studies should involve optimization of enzyme purification in industrial scale and finding more CCP potential applications which should increase the advantages of this promising enzyme.
Evaluating food metrics of lanternfishes in waters of the southeastern Pacific Ocean
Authors: Carcamo Carolina , Espinoza Pepe , Canales-Cerro Carlos , Curaz-Leiva Stephanny , Guzman Ana Brisca , Quintanilla Ivonne , Vargas Fernanda , Zuñiga Mauricio , Fernandoy Francisco , Galvez Patricio , Vargas Rene , Saavedra Alvaro , Harrod Chris , Schultz Eric T , Klarian Sebastian 
Published: September 2022

Abstract
Using carbon and nitrogen stable isotope values, we analyzed the trophic position (TP) and the isotopic niche width of lanternfishes from three different fishing grounds in the Southern Pacific Ocean. Fishes from Perú had slightly higher δ13C values compared with fish from Chilean fisheries grounds. In contrast, δ15N values increased with latitude (North to South). Myctophids TP differed between the three fishing grounds (highest in Central Chile, lowest in Peru). Peruvian fishes had a smaller isotopic niche than the lanternfishes of the Chilean fishing grounds.
Radiographic prediction of Colles fracture displacement after splint fixation-a prospective study of 97 patients
Authors: Meng Zezhen , Liu Xin , Chen Hao , Du Bin , Wei Chengjian 
Published: September 2022

Abstract
Objective: The study aimed to prospectively analyze the relevant radiographic data before and after the reduction of Colles fractures with splint fixation, to analyze the related influencing factors of fracture redisplacement from the perspective of imaging indicators, and to predict the key factors through artificial machine learning. The predictive value of the screened key factors may provide a reference for the prognosis judgment of the subsequent clinical application of splint in the treatment of Colles fractures.
Methods: The study included 97 adult Colles fracture patients from January 2018 to October 2021 in the outpatient and emergency department of the Affiliated Hospital of Nanjing University of Chinese Medicine. The basic data of the patients, as well as standard frontal and lateral radiographs of the wrist before reduction, immediately after reduction, and 4 weeks after reduction and fixation were recorded. Data were collected from Radiograph. Grouping and statistics were performed according to whether fracture displacement occurred at the end of the 4-week follow-up after reduction and fixation. Two statistical methods were used for analysis to explore the risk factors for displacement, and the risk factors were were listed independently and analyzed and predicted by random forest method.
Results: 31 patients were judged to be displaced at the end of follow-up, and an additional 66 patients were judged to be in good fracture position. The statistical analysis results showed that the risk factors for displacement after Colles fracture with splints predicted by both methods were the absence of anatomic alignment of the volar cortex, dorsally comminution, and anterior radial displacement before reduction. The above three factors were listed independently and analyzed and predicted by random forest method. The results showed that the AUC area predicted by these three indicators was 0.823, which has an ideal prediction accuracy.
Conclusion: Malalignment of the volar cortex, dorsal comminution, and radial displacement before reduction are independent risk factors for fracture redisplacement after conservative splinting of Colles fractures. Predicting fracture redisplacement based on the above conditions has reliable accuracy. For patients with the above conditions, the choice of splinting therapy should be cautious and should be fully communicated with the patient in order to achieve a better clinical prognosis.
Level of evidence:Level Ⅳ; Case series
Trajectories of depressive symptoms and their predictors in Chinese elderly population: growth mixture model
Authors: Xie Yaofei , Ma Mengdi , Wang Wei 
Published: September 2022

Abstract
Background
Given the acceleration and deepening of China's aging process and the relatively high prevalence of depressive symptoms in Chinese elderly population, this study aimed to identify the trajectories of depressive symptoms and factors associated with trajectory class to gain a better understanding of the long-term course of depressive symptoms in Chinese elderly population.
Methods
Data were obtained from four waves’ survey of China Health and Retirement Longitudinal Study (CHARLS). A total of 3646 participants who aged 60 or older during baseline survey and completed all follow-ups were retained in this study. Depressive symptoms were measured using the 10-item version of the Centre for Epidemiologic Studies Depression Scale (CES-D-10). Growth mixture modelling (GMM) was adopted to identify the trajectory classes of depressive symptoms, and both linear function and quadratic function were considered. Multivariate logistic regression model was performed to calculate adjusted odds ratios (ORs) of associated factors to predict trajectory class of the participants.
Results
The four-class quadratic function model was the best fitting model of the trajectories of depressive symptoms in Chinese elderly population. The four trajectories were labelled increasing (16.70%), decreasing (12.31%), high and stable (7.30%) and low and stable (63.69%) according to their trends. Except low and stable trajectory, other trajectories were almost above the critical line of depressive symptoms. Multivariate logistic regression model suggested that trajectories of chronic depressive symptoms could be predicted by being female, living in village, having lower education level and suffering from chronic diseases.
Conclusions
This study identified four depressive symptoms trajectories in Chinese elderly population and analysed associated factors of trajectory class. These findings can provide references for the prevention and intervention work to reduce chronic course of depressive symptoms in Chinese elderly population.
Comparison of the effect of parenting education through multimedia and social media on parenting stress of nurses in COVID Pandemic
Authors: Abbasi Mahnaz , Aliyari Shahla , Farsi Zahra , Khalaji Marzieh 
Published: September 2022

Abstract
Introduction:
The prevalence of the COVID virus has increased nurses’ stress and has affected aspects of their lives such as nurses' relationships with their children. This study aimed to compare the effect of parenting education through multimedia and social media on nurses' parental stress in the COVID pandemic.
Methods
This quasi-experimental study was conducted in 2020 in the selected hospitals in Tehran, Iran. Hospitals were randomly assigned to experimental (multimedia and social media) and control groups (n = 20). Sixty female nurses with children aged 2–5 years were recruited by convenience sampling. Four DVDs, each containing 5 training sessions, were presented to nurses in the multimedia group for four weeks. In the social media group, educational materials were presented in the PowerPoint voiced and delivered to nurses with Rubika and WhatsApp messengers in 20 sessions over four weeks. There was no intervention in the control group. Data were collected using Parenting Stress Index before and two weeks after the intervention.
Results
There was no significant difference between nurses' parental stress scores in multimedia, social media, and control groups before the study (P = 0.956); while this difference was significant two weeks after the intervention (P < 0.0001). So that the nurses' parental stress score in the multimedia group decreased from 83.47 ± 15.46 to 71.16 ± 9.97 (P < 0.0001), in the social media group from 81.5 ± 15.34 to 51.11 ± 3.479 (P < 0.0001), and in the control group increased from 82.9 ± 15.23 to 82.30 ± 15.74 (P = 0.809). Parenting education was more effective in the social media group (P < 0.0001).
Conclusion
Parenting education with social media has a more impact on nurses' parental stress compared to multimedia. Therefore, using this method for psychological training is recommended to reduce nurses’ stress and improve their performance.
Pregnancy-induced Physiological Hypertrophic Preconditioning Attenuates Pathological Myocardial Hypertrophy by Mnemonic Activation of FoxO3a/GSK3β Pathway
Authors: Liao Yulin , Xie Jiahe , Zheng Cankun , Shen Mengjia , Lu Weiling , Li Mingjue , He Mingyuan , Chen Lu , Ma Siyuan , Zhu Yingqi , Lin Hairuo , Xiu Jiancheng , Liao Wangjun , Bin Jianping 
Published: September 2022

AbstractPrevious studies show a woman’s age at final pregnancy is correlated with post-reproductive longevity and nulliparity is associated with higher risk of incident heart failure, and we previously reported a cardioprotective phenomenon termed myocardial hypertrophic preconditioning, but it is unknown whether pregnancy-induced physiological hypertrophic preconditioning can also protect the heart against subsequent pathological hypertrophic stress. Here, we found that compared with nulliparous mice, pathological cardiac hypertrophy induced by Ang Ⅱ infusion or TAC was significantly attenuated and heart failure induced by TAC was markedly improved in mice with pregnant preconditioning. Activation of FoxO3a was significantly enhanced in the hearts of postpartum mice. FoxO3a inhibited myocardial hypertrophy by suppressing signaling pathway of phosphorylated glycogen synthase kinase-3β (p-GSK3β)/β-catenin/Cyclin D1. Silencing or overexpression of FoxO3a attenuated or enhanced the anti-hypertrophic effect of pregnant preconditioning in mice with pathological stimulation. Our findings demonstrate that pregnancy-induced myocardial hypertrophic preconditioning confers resistance to subsequent hypertrophic stress and slows progression to heart failure through activation of FoxO3a/GSK3β pathway.
The status and associated factors of earlychildren caries among Preschoolchildren in Chongming islet， China: across-sectional survey
Authors: Yang Chao , Huang Xiaoxiao , Yu Ruihua , Jiang Feng , Qin Hui 
Published: September 2022

Abstract
Background: Dental caries of preschool children (Early Children Caries, ECC) has become a crucial oral health problem. The aim of this research was to investigate the prevalence of dental caries among preschool children from Chongming islet and analyze the related factors.
Methods: A total of 939 preschool children from 5 kindergartens in Chongming islet of China were selected by random sampling method from January to April 2022 to study the incidence of dental caries and related risk factors.
Results: The prevalence of ECC in Chongming islet was 45.69%, the mean dmft was 2.911±1.568. In multivariable modeling, eating dessert between meals or before sleeping (OR=3.049, P <0.001), sweetened milk (OR=2.389, P =0.027), the caregiver had dental caries (OR=1.888, P <0.001), age of children (OR=1.758, P <0.001),preference of beverages (OR = 1.250, p = 0.029), and frequency of snacking (OR = 1.191, p = 0.034) are independent risk factors for the development of ECC, brushing teeth time of children (OR = 0.765, p = 0.77) and caregivers help children brushing teeth or check children brushing effect (OR = 0.788, P =0.066) were protective factors for children's dental caries.
Conclusions: Children should reduce the frequency of eating snacks, reduce the consumption of sugary beverages, sweet food, and train children to brush their teeth correctly, ensure the effect of brushing teeth, urge children to develop good oral hygiene habits, which is helpful to reduce the risk of dental caries in children.
Characterization of a zoonotic rotavirus strain isolated from diarrheic rabbits
Authors: zhao qiaoya , Liu Liping , Huang Tao , Tian Ye , Guo Xiaozhen , Liu Cunxia , Huang Bing , Chen Qiusheng 
Published: September 2022

Abstract
Children and multiple species of domestic animals are susceptible to infection of group A rotaviruses (RVAs) that causes acute gastroenteritis. We isolated an RVA (Z3171) from diarrheic rabbits and characterized its whole-length genome and pathogenicity in rabbits. The genotype constellation of Z3171 was as follows: G3; P[22]; I2; R3; C3; M3; A9; N2; T1; E3; H3,which is different from the constellation observed in previously characterized LRV strains. The result showed that the NSP3 gene of Z3171 belonged to the T1 genotype and shared 96.2% nucleotide identities with other T1 human strain LL4260 circulating in the regions. However the genome of Z3171 differed substantially from that of the other rabbit rotavirus strains, N5 and Rab1404, in terms of both gene content and gene sequence, particularly the NSP5 gene. Our study shows a reassortment event between human and rabbit rotavirus strains, or there may be undetermined gene clusters circulating in the rabbit population. The isolated strain can cause diarrhea in Belgian rabbits in animal regression test. The infection rate was 100%, and the incidence rate was 80%. Further, we report the detection of G3P[22] RVA strain in rabbits from China for the first time.
Critical incidents during anesthesia: prospective cohort study
Authors: Bielka K. , Kuchyn I. , Frank M. , Sirenko I. , Yurovich A. , Slipuha D. , Lisnyy I. , Soliaryk S. , Posternak G. 
Published: September 2022

Abstract
Background: a critical incident reporting and analysis is one of the key components of patient safety in anesthesiology. The aim of this study was to determine the frequency and characteristics of critical incidents during anesthesia, main causes and factors involved, influence on patients outcomes, prevalence of emergency notification and response systems.
Methods: A multicenter prospective cohort study was conducted at the clinical departments of Bogomolets National Medical University (postgraduate department of surgery, anesthesiology and intensive care)during the period from 1 June 2021 to 1December2021. 13 hospitals from different Ukraine regions took part in the study. The study design was approved by the Bogomolets National Medical University (NMU)ethics committee, protocol #148, 07.09.2021.
Results: The mean incidence of critical incidents during anesthesia in Ukraine was 0.94% (ranging from 0.04% to 3.4% on different sites). Most common incidents were related to the respiratory system: difficult airway (26.8%), reintubation (6.4%), oxygen desaturation (13.8%); cardiovascular system: hypotension (14.9%), tachycardia (6.4%), bradycardia(11.7%), hypertension (5.3%), collapse (3.2%); massive hemorrhage (17%).
Surprisingly emergency situations often occurred while treating patients considered low-risk as assessed by an anesthesiologist (ASA II – 57.4%) and during planned surgical interventions (63.2%). Among common reasons that could lead to the incident, the treating physicians have identified: individual patient features (47%), surgical tactics (18%), anesthesia (16%) and human factor (12%). The most frequent shortcomings of the patient management were: preoperative assessment (44%), incorrect interpretation of the patients’ state (33%), faulty manipulation technique (14%), miscommunication (13%) and delay in emergency care provision (10%). Furthermore, 48% of cases, as judged by participating physicians, were preventable and the consequences of another 18% could be minimized. The consequences of the emergency situations were insignificant in over a half of the cases, but in 24.5% have led to protracted hospital stay with 30 patients (16%) being urgently transferred to the ICU and 12 (6.5%) dying in the hospital.34.8% of reported incidents were not documented otherwise and 16.3% were not reported to the chief of department. The emergency situation was followed by a detailed examination within the department in 58.1% of cases with 6.5% resulting in a permanent policy change.
Conclusion: Critical incidents during anesthesia occur rather often and impact the treatment results significantly. Notification, registration and analysis of such incidents are not being performed systematically, which proves to be one of the major threats to patient safety during anesthesia.
Study registration: NCT05435287, clinicaltrials.gov, 28/06/2022
OR2H2 Activation Suppresses Cellular Senescence and Aging by Activating AMPK and Inducing Senolysis in VK2/E6E7 Cells
Authors: Kim Ji Min , Dziobaka Sina , Yoon Ye Eun , Lee Ha Lim , Jeong Ji Hyun , Lee In-Ryeong , Weidinger Daniel , Yang Changwon , Kim Deokho , Gulperi Yalcin , Lee Cheol-Koo , Sohn Jeongwon , Song Gwonhwa , Hatt Hanns , Lee Sung-Joon 
Published: September 2022

Abstract
Background
Olfactory receptors are expressed in multiple extra-nasal tissues and these ectopic olfactory receptors mediate tissue specific functions and regulate cellular physiology. Ectopic olfactory receptors may play key roles in tissues constantly exposed to odorants, thus functionality of these receptors in genital tissues are of particular interest. The functionality of ectopic olfactory receptors expressed in VK2/E6E7 human vaginal epithelial cells was investigated.
Results
OR2H2 was functionally expressed in VK2/E6E7 cells and activation of OR2H2 by aldehyde 13–13, a ligand of OR2H2, increased the intracellular calcium and cAMP concentrations. Immunoblotting demonstrated that activation of OR2H2 by aldehyde 13–13 stimulated the CAMKKβ-AMPK-mTOR-autophagy signaling axis, and that these effects were negated by OR2H2 knockdown. Autophagy activation suppressed aging and cellular senescence. Activation of OR2H2 by aldehyde 13–13 restored proliferation, reduced the expression of senescence markers, P16 and P19 in H2O2-induced senescent cells. Additionally, aldehyde 13–13 showed senolytic activity by predominantly inducing apoptosis of H2O2-induced senescent cells compared with non-senescent normal cells. In vivo, aldehyde 13–13 increased the lifespan of Caenorhabditis elegans and budding yeast.
Conclusions
These findings demonstrate that OR2H2 is a functional receptor in VK2/E6E7 cells and activation of OR2H2 activates AMPK-autophagy axis, suppresses cellular aging and senescence, thus may increase cellular lifespan.