bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wetland ecological restoration and payment for ecosystem service standard: A case study of Ganjiangyuan National Wetland Park
Authors: Zhou Yu , Li Zhaohua , Zhao Liya 
Published: March 2022

Abstract
The wetland resource in the wetland park is a unique natural resource, which is of great significance in maintaining regional ecological security. The ecological restoration and ecological compensation of wetland parks are related to the construction and sustainable development of the park, as well as the comprehensive ecological environment of the city. Ganjiangyuan National Wetland Park is one of the wetland parks in inland China. Discussing the ecological restoration and ecological compensation standards of the wetland park has an important guiding role in the construction of the wetland ecological protection system in Shicheng County, Jiangxi Province. Wetland ecosystem evaluation methods, ecological service value tables, and willingness to accept are used to evaluate and calculate the wetland ecosystem in Ganjiangyuan National Wetland Park. The study concluded that the wetland ecosystem evaluation result of Ganjiangyuan National Wetland Park was “excellent”. For Ganjiangyuan National Wetland Park, an ecological service value index system with regulation services as the mainstay was constructed. Based on the mathematical expectation formula of WTA and the calculation principle of reducing the value of adjustment services as the upper limit of ecological compensation, the upper and lower limits of the ecological compensation standard in the study area are calculated to be 210.49 yuan/hm²·year and 157.87 yuan/hm²·year separately. The ecological compensation mechanism has been progressing and improving. Therefore, the results of this study are only applicable to the current time period, and future development and changes will become a kind of uncertainty.
Incidence of and risk factors for severe neutropenia during treatment with the modified FOLFIRINOX therapy in patients with advanced pancreatic cancer
Authors: Irisawa Ai , Takeno Misaki , Watanabe Kazuo , Takahashi Hideaki , Mitsunaga Shuichi , Ikeda Masafumi 
Published: March 2022

Abstract
Background
Although FOLFIRINOX (oxaliplatin, irinotecan, 5-FU, and l-leucovorin) is established as one of the standard therapies for patients with metastatic pancreatic cancer, the modified FOLFIRINOX (mFOLFIRINOX) is often used in clinical practice to reduce the incidence of toxicities. Febrile neutropenia (FN) and severe neutropenia during FOLFIRINOX are especially frequently observed in Japanese patients. In this study, we evaluated the incidence of FN and severe neutropenia, and explored the risk factors for severe neutropenia in patients receiving treatment with mFOFIRINOX.
Methods
The data of patients who had received mFOLFIRINOX between December 2013 and December 2014 at the National Cancer Center Hospital East were reviewed retrospectively. We graded the neutropenia severity and defined ≥ Grade 3 neutropenia as severe neutropenia. Univariate and multivariate analysis were undertaken to evaluate the associations with risk of development of severe neutropenia.
Results
A total of 122 patients were enrolled in this study. Sixty two patients (51%) and 10 patients (8%) developed severe neutropenia and FN, respectively. Multivariate analysis identified a low baseline white blood cell count (odds ratio [OR], 14.50; 95% confidence interval (CI), 3.27-111.14; p = 0.002) and presence of heterozygosity for UGT1A1*28 or UGT1A1*6 polymorphism (OR, 2.84; 95% CI, 1.18–7.17; p = 0.023) as independent risk factors for severe neutropenia.
Conclusion
The incidences of severe neutropenia and FN in patients receiving mFOLFIRINOX in our clinical practice were comparable to previous reports. The risk factors for severe neutropenia in patients receiving mFOLFIRINOX were a low baseline white blood cell count and presence of heterozygosity for UGT1A1*28 or UGT1A1*6 polymorphism.
Age-adjusted Charlson Comorbidity Index as a predictor of all-cause mortality risk in older adult patients with obstructive sleep apnea: a prospective cohort analysis
Authors: Gao Yinghui , Wang Huanhuan , HU Yazhuo , Li JianHua , Xu Weihao , Zhao LiBo , Su Xiaofeng , Han Jiming , Li Tianzhi , Fang Xiangqun , liu lin 
Published: March 2022

Abstract
Background: To explore the prognostic and therapeutic value of the age-adjusted Charlson Comorbidity Index (ACCI) for patients with obstructive sleep apnea (OSA) aged 60 years and older.Methods: Between January 2015 and October 2017, this multicenter, prospective, observational cohort study continuously enrolled 1183 older patients (age ≥60 years) with clinician-diagnosed OSA (sleep-laboratory-based overnight polysomnography) from sleep centers of six hospitals. Baseline demographics, clinical characteristics, sleep parameters, and medical history were obtained from electronic patient records, the ACCI was calculated, and participants were followed up prospectively to determine the primary outcome of all-cause mortality. Based on an ACCI cutoff of 4.5, participants were classified into the low-ACCI and high-ACCI groups and the receiver operating characteristic (ROC) curves were plotted. Kaplan–Meier survival analysis with log-rank test and Cox proportional hazards regression modeling was performed.Results: During a median 43-month follow-up, 63 (5.3%) patients died. ROC curves revealed an optimal ACCI cutoff of 4.5, and the area under the curve (AUC) of 0.70 [95% confidence interval (CI): 0.63–0.77] reached statistical significance (P<0.001). Kaplan–Meier survival analysis revealed 6-year survival rate of 56.04% and 92.17% for the high-ACCI and low-ACCI (ACCI ≥5 and <5; n=336 and n=847) groups, respectively. Regardless of sex or OSA severity, the ACCI was associated with the all-cause mortality risk of older OSA patients (log-rank, both P<0.001). After controlling for confounding variables, the mortality risk was 3.32 times (95% CI: 1.91–5.77) higher in the high-ACCI group than in the low-ACCI group. Multivariate Cox stepwise regression analyses indicated that total sleep time (TST), Mean Corpuscular Volume (MCV), and ACCI (aHR [95% CI]=1.258 [1.053–1.503], 1.047 [1.007–1.087], and 1.583 [1.384–1.815]; P=0.011, 0.019, and 0.000, respectively) were significant independent predictors of all-cause mortality.Conclusion: The ACCI is a predictor of all-cause mortality in older OSA patients (age≥60 years), with a higher ACCI indicating a higher mortality risk. The ACCI can guide clinical treatment selection for older OSA patients.
Characterization of a marine intrusion using electrical sounding and seismic refraction: case of the the Oued Nador plain (Tipaza, Algeria)
Authors: Bechkit Mohamed Amine , Bourouis Seid , Mouhoub Fayçal Chafiheddine , Aichaoui Moussa , Arrache Khiereddine 
Published: March 2022

Abstract
The present study aims to charcaterize, by geophysical methods (electrical sounding and seismic refraction), the downstream part of the Oued Nador alluvial layer or deposits (Tipaza, Algeria) and the morphology of its bedrock to better locate the freshwater-saltwater limit. This will allow to better understand the marine intrusion.Indeed, the aquifer is defined by a clay and marl substratum of middle to lower Pliocene Piacenzian age rich in recent Neogene and Quaternary filling (Quaternary alluvium composed of sand, gravel and pebbles). During Spring of 2015, 2016, and 2017 three electrical surveys were conducted. The results indicate that the origin of the salinity is due to progressive marine intrusion inside the aquifer (Bechkit et al, 2017; Bechkit et al, 2018a; Bechkit et al, 2018b). However the presence of clay makes the contrast between the saltwater and the clays less important so that it is difficult distinguish electrically the two mediums. In May 2018, we combined both electrical survey and a refraction seismic acquisition on the area of study. This work was carried out in order to separate, through the ranges of wave propagation velocity, the saltwater formations from the clay ones. The presence at a certain distance from the coast of an elevation of the clay bedrock has an advantage. Indeed, it acts as a natural barrier against any intrusion on a large scale of saltwater at depth. The study carried out in this context showed that the combination of two geophysical methods is very useful in environmental study for the evaluation of the salt water intrusion in an alluvial ground in the presence of clay formations.
Impact of climate change on hydrochemical properties and quality of groundwater for domestic and irrigation purposes in arid environment: A case study of Al-Baha region, Saudi Arabia
Authors: Alghamdi Abdulaziz G. , Aly Anwar A. , Majrashi Mosaed A. , Ibrahim Hesham M. 
Published: March 2022

Abstract
Over-exploitation of groundwater, rising temperature, and declined precipitation have resulted in groundwater quality deterioration, subsequently affecting human health and agricultural productivity. Therefore, to evaluate the suitability of groundwater for domestic and irrigation purposes, groundwater samples were collected from 88 locations in Sarat Al-Baha region, Saudi Arabia. The hydrochemical characteristics were assessed to evaluate the suitability of groundwater for drinking and irrigation purposes. The results revealed that most groundwater samples were medium to highly salinity hazards; nevertheless, no sodicity hazards were expected. By using the water quality indices, 70.5% of studied waters were class II. Nevertheless, 91% of collected samples were in acceptable concentrations of heavy metals and nitrate. The saturation index showed that the groundwater was largely under-saturated with most minerals, indicating a possibility of salinity increase due to increasing the concentration of iron, calcium, magnesium, sodium, chloride and sulfate due to the dissolution of under-saturated minerals. Due to the increased salinity levels, more than 90% of the collected groundwater samples showed low quality for irrigation due to higher potential for salinity problems. Furthermore, the development of salinity of groundwater in Sarat Al-Baha could be the result of the increased temperatures and decreased rainfall. Therefore, it is recommended to implement appropriate management practices to optimize groundwater usage and decrease the potential of further deterioration in its quality. The discharge of groundwater need to be controlled, strictly preventing the drilling of new wells. It is also important to assess the suitability of planted crops, and implement proper water management practices to sustain groundwater resources in Sarat Al-Baha region. The approach used in this study can be used to alike environment worldwide.
Imaging the distribution of bitumen contaminants in shallow coastal plain sands in Southwestern Nigeria using electrical resistivity
Authors: Jekayinfa Solomon Solomon , Oladunjoye Michael A. , Doro Kennedy O. 
Published: March 2022

Abstract
Naturally occurring bitumen seeps within the shallow subsurface contaminates soil and groundwater in communities within the eastern segment of the Dahomey Basin in southwestern Nigeria. Managing these contaminations require an understanding of the distribution of the bitumen seeps to isolate contaminated regions to avoid farming activities or drilling shallow drinking water wells within them. Several studies have assessed the shallow occurrence of bitumen in the region, focusing on their economic potentials and ignoring current challenges with soil and groundwater contamination in these communities. This study focuses on using electrical resistivity techniques with limited soil cores to delineate the distribution of bitumen seeps within the shallow subsurface in Imakun-Omi community in southwestern Nigeria. We used both 1D and 2D numerical and field approaches in this study. 13 vertical electrical soundings using a Schlumberger electrode array were first acquired to obtain the bulk resistivities and layer thicknesses. The 1D resistivity alongside well lithologic data served as prior data for a forward modelling study to assess the capability of resolving the bitumen seeps within electrically resistive coastal sands. Results of the forward modelling studies guided the acquisition of five 2D electrical resistivity profiles used to image the distribution of bitumen seeps using a Wenner electrode array with a unit electrode spacing of 2 m. Results of this study show that bitumen seeps with resistivities greater than 3, 000 Ohm-m are distributed within the top 4 m in the area and extends down to 10 m in some locations. Our numerical studies show that despite difficulties in imaging bitumen seeps within sediments overlain by higher electrical resistivity layers, reliable results can be derived, thus proving the versatility of electrical resistivity in delineating areas contaminated by bitumen seeps within shallow coastal sands.
Symptom burden and shared care planning in an oncology nurse-led primary palliative care intervention (CONNECT) for patients with advanced cancer
Authors: Mitchell Chandler Jonathan , Althouse Andrew , Feldman Robert , Resick Judith M. , Arnold Robert M. , Rosenzweig Margaret , Smith Kenneth , Chu Edward , White Doug , Smith Tom , Schenker Yael 
Published: March 2022

Abstract
Purpose: Primary Palliative Care (PPC) interventions are needed to address unmet symptom needs within standard oncology care. We designed an oncology nurse-led PPC intervention using shared care planning to facilitate patient engagement. This analysis examines the prevalence and severity of symptoms reported by patients and how symptoms were addressed on shared care plans.Methods: Secondary analysis of a cluster randomized PPC intervention trial. Adult patients with metastatic solid tumors whose oncologist ‘would not be surprised if the patient died within a year’ were included. Twenty-three oncology nurses received PPC training and conducted up to three monthly visits with patients. Symptom prevalence and severity were assessed prior to each visit using the Edmonton Symptom Assessment Scale (ESAS; 9 symptoms ranked 1-10 with scores ≥4 indicating moderate severity). Nurses collaboratively developed treatment strategies with patients, targeting the most bothersome symptoms for improvement.Results: Among 571 nurse-led PPC visits with 235 patients, the most prevalent and severe symptoms were tiredness (reported at 86% of visits; ESAS ≥4 in 55% of visits), low sense of well-being (78%; ESAS ≥4 in 38%), and poor appetite (69%; ESAS ≥4 in 42%). Moderately severe symptoms were addressed on shared care plans ranging from 4% (drowsiness) to 35% (tiredness) of the time. Symptom management plans developed by PPC-trained oncology nurses primarily focused on non-pharmaceutical interventions (70%) compared to pharmaceutical interventions (30%). Conclusion: The symptoms that patients report most frequently and as most severe on shared care plans were addressed less frequently than expected. Further research is needed to understand how primary palliative care interventions can be designed to more effectively target and improve bothersome symptoms for patients with advanced cancer.
Psychological care over patients with lymphoma and lymphoma survivors.
Authors: Warchoł-Biedermann Katarzyna , Mojs Ewa , Samborski Włodzimierz , Kotyla Przemysław 
Published: March 2022

Abstract
Purpose
Lymphomas are characterized by a relatively favorable prognosis and a good five-year survival rate but they are associated with increased psychosocial distress. There is a gap in the knowledge on the effectiveness of psychological interventions for lymphoma patients. This review aimed to present the research findings on currently used psychological interventions for (non-) Hodgkin lymphoma patients and survivors.
Methods
A literature search on English language peer-reviewed original publications on psychological interventions for lymphoma patients published prior to December 2021 was performed in PubMed, Medline, Web of Science, Scopus and ResearchGate. Titles and abstracts were screened for the relevant terms including psychological intervention and psychological management along with (non-) Hodgkin lymphoma. The retrieved articles were evaluated by independent reviewers, the lists of eligible publications were compared and disagreements were resolved by discussion.
Results
Of the 50 publications sought for retrieval, 8 articles were shortlisted based on their content. The papers were classified according to their content and the methodology employed. Research themes including "promoting resilience in lymphoma survivors", "web-based self-management interventions for patients with lymphoma", "addressing unmet needs whilst undergoing chemotherapy", and "mind-body interactive exercise" were identified and presented in this review.
Conclusions
As the number of lymphoma survivors is increasing, future research on evidence-based interventions addressing patients' and survivors' unmet psychological needs is warranted.
113 km Free-Space Time-Frequency Dissemination at the 19th Decimal Instability
Authors: Zhang Qiang , Shen Qi , Guan Jian-Yu , Ren Ji-Gang , Zeng Ting , Hou Lei , Li Min , Cao Yuan , Han Jin-Jian , Lian Meng-Zhe , Chen Yan-Wei , Peng Xin-Xin , Wang Shao-Mao , Zhu Dan-Yang , Shi Xi-Ping , Wang Zheng-Guo , Li Ye , Liu Wei-Yue , Pan Ge-Sheng , Wang Yong , Li Zhao-Hui , Wu Jin-Cai , Zhang Yan-Yan , Chen Fa-Xi , Lu Chao-Yang , Liao Sheng-Kai , Yin Juan , Jia Jian-Jun , Peng Cheng-Zhi , Jiang Hai-Feng , Pan Jian-Wei 
Published: March 2022

Abstract
Optical clock networks play important roles in various fields, such as precise navigation, redefinition of “second” unit, and gravitational tests. To establish a global-scale optical clock network, it is essential to disseminate time and frequency with a stability of 10^−19 over a long-distance free-space link. However, such attempts were limited to dozens of kilometers in mirror-folded configuration. Here, we take a crucial step toward future satellite-based time-frequency disseminations. By developing the key technologies, including high-power frequency combs, high-stability and high-efficiency optical transceiver systems, and efficient linear optical sampling, we demonstrate free-space time-frequency dissemination over two independent links with femtosecond time deviation, 3 × 10−19 at 10,000 s residual instability and 1.6 × 10^−20 ± 4.3 × 10^−19 offset. This level of the stability retains for an increased channel loss up to 89 dB. Our work can not only be directly used in ground-based application, but also firmly laid the groundwork for future satellite time-frequency dissemination.
Characterization of codon usage pattern and evolutionary changes of Human Enterovirus 71 in China
Authors: Wang Meng , Chen Li , Sun Penghui , Jin Wangjie , Han Yanjiang , Huang Shun 
Published: March 2022

Abstract
Background: Enterovirus 71 (EV71) is a common etiological agent of hand, foot and mouth disease (HFMD) in children, which caused large outbreaks in mainland China in 2008. However, the genetic information of EV71 strains circulating in China is limited. Methods: Here, we performed a systematic evolutionary and codon usage bias analysis of EV71. Result: The result shows that the overall extent of codon usage bias in EV71 is low (ENc=56.696), and natural selection, mutation pressure, nucleotide compositions and host shape the codon usage patterns of EV71, with natural selection being more important than the others. We also found EV71 breaking out in large scale in 2008, the codon usage pattern of the virus isolated from China has change a lot compare the previous isolates, and after 2008, three different codon usage patterns were popularized in China. Conclusion: In the end, we've confirmed that C2 isolates has outbreak in China before 2000 through codon usage analysis for the first time. In conclusion, our results provide useful insights into the evolutionary relationships of EV 71.
Extracting the anisotropy information of crustal rocks from the seismological garbage
Authors: Xu Li-Sheng , Zhe Zhang , Zhen Fu , Li Chun-Lai 
Published: March 2022

Abstract
Human has been eagerly expecting to know some information that can indicate a large earthquake’s impending1,2,3,4,5. Decades of efforts showed that the impending of large earthquakes was usually accompanied by a process of regional weakening manifested with multiple temporal and spatial scaled deformation, and such a deformation was often accompanied by clusters or swarms of micro-earthquakes6, which further caused observable change in anisotropy of nearby rocks7,8,9,10. Here we show that the anisotropy information of crustal rocks may be extracted from the seismological garbage, the travel-time residuals produced by dense seismic stations which record clusters or swarms of micro-earthquakes, by means of a new concept, the slowness deviation tensor expressing 3-axis slowness anisotropy. In particular, we present a real example to justify that the slowness deviation tensor with arbitrarily inclined axis may be successfully extracted from the travel-time residual data, and meanwhile to demonstrate that this anisotropy reflected by the extracted tensor mainly originated from the local stress action or deformation. Undoubtedly, this work provides a completely new methodology to link the clusters or swarms of micro-earthquakes with the weakening process which occur before large earthquakes, which essentially contributes a promising direction toward the information that human has been expecting for.
Removal efficiency and migration characteristics of naphthalene in bioretention facilities: the influences of particulate matter
Authors: Xu Yan , Li Haiyan , Zhang Xiaoran , Bai Xiaojuan , Wu Liyuan , Tan Chaohong , Zhang Ziyang 
Published: March 2022

Abstract
Particulate matter (PM), as an important carrier for carrying and transporting runoff pollutants, can significantly affect the behavior and removal efficiency of pollutants in bioretention facilities. In order to control the pollution caused by polycyclic aromatic hydrocarbons (PAHs) in bioretention facilities, the removal efficiency and migration characteristics of typical PAHs-naphthalene were systematically investigated under the influences of PM. The results showed that the removal efficiency of naphthalene was 74% ~ 97% in bioretention facilities under the influences of PM. With the higher naphthalene concentration, the lower rainfall return period, and the longer antecedent drying period, the removal efficiency of naphthalene in each media layer were higher. Furthermore, the PM in the runoff increased the naphthalene adsorption onto media in the first 10 cm depth, which showed more than 80% removal efficiency and lower mobility of naphthalene. The removal efficiency of naphthalene was significantly higher (90% ~ 97%), when the particle size and concentration of PM were 0 ~ 45 µm and 500 mg/L, respectively. This study investigated the important role of PM for naphthalene removal in bioretention facilities, and provided effective guidelines for runoff pollution control, design of stormwater facilities, and assessment risk of PAHs.