bluuebunny/crossref_metadata_2025_split huggingface dataset:
Varieties of Data-Centric Science: Regional Climate Modeling and Model Organism Research
Authors: Lloyd Elisabeth , Lusk Greg , Gluck Stuart , McGinnis Seth 
Published: February 2022

AbstractModern science’s ability to produce, store, and analyze big datasets is changing the way that scientific research is practiced. Philosophers have only begun to comprehend the changed nature of scientific reasoning in this age of “big data.” We analyze data-focused practices in biology and climate modeling, identifying distinct species of data-centric science: phenomena-laden in biology and phenomena-agnostic in climate modeling, each better suited for its own domain of application, though each entail trade-offs. We argue that data-centric practices in science are not monolithic because the opportunities and challenges presented by big data vary across scientific domains.
Explicit calculations in an infinitesimal singular block of SLn
Authors: Hardesty William 
Published: February 2022

AbstractLet $G= SL_{n+1}$ be defined over an algebraically closed field of characteristic $p > 2$. For each $n \geq 1$, there exists a singular block in the category of $G_1$-modules, which contains precisely $n+1$ irreducible modules. We are interested in the ‘lift’ of this block to the category of $G_1T$-modules. Imposing only mild assumptions on $p$, we will perform a number of calculations in this setting, including a complete determination of the Loewy series for the baby Verma modules and all possible extensions between the irreducible modules. In the case where $p$ is extremely large, we will also explicitly compute the Loewy series for the indecomposable projective modules.
Pliocene–Quaternary seismogenic faults in the inner Northern Apennines (Valdelsa Basin, southern Tuscany) and their role in controlling the local seismicity
Authors: Mirabella Francesco , Braun Thomas , Brogi Andrea , Capezzuoli Enrico 
Published: February 2022

AbstractPliocene–Quaternary faults are relevant structures with which to constrain the seismotectonic context and contribute to the evaluation of the seismic hazard of a region. Many of these faults, however, do not show clear surface evidence even when releasing earthquakes. For these reasons they can be extremely dangerous as they receive relatively little attention and can be difficult to identify. From among the various surface geology studies and/or palaeoseismological investigations, we focus our attention on the integration of different datasets such as seismic reflection profiles, surface kinematic data and the relocation of seismological data, which make it possible to identify and characterize active faults whose dimension and earthquake potential would otherwise not be large enough to make them identifiable. We take as an example the Montespertoli NE-trending fault in southern Tuscany (central Italy) with which we associate the 2016 M=3.9 Castelfiorentino earthquake. This structure is part of a wider (in the order of 15–20 km) crustal-scale shear zone, which may be responsible for strong historical earthquakes in the area.
Insights on the fish assemblages of seamounts and banks in the southern Tyrrhenian Sea (western Mediterranean Sea): implications for the conservation of deep-sea environments
Authors: La Mesa Gabriele , Consalvo Ivan , Angiolillo Michela , Giusti Michela , Tunesi Leonardo 
Published: February 2022

AbstractFish assemblages inhabiting a complex of south Tyrrhenian seamounts and banks were characterized using a remotely operated vehicle (ROV). Fish distribution was assessed through surveying 15 ROV transects. Video segments of each transect were split into two bathymetric ranges, above and below 200 m depth. In total 28 fish taxa belonging to 22 families were recorded. The number of species observed at the Marettimo Banks and the Aceste Seamount was higher compared with the Tiberio and Scuso Seamounts. The number of species recorded in the shallow part (<200 m depth) of the Marettimo Banks and the Aceste Seamount was higher than in the deeper zone (>200 m). Assemblages were numerically dominated byAnthias anthias,Callanthias ruberandHelicolenus dactylopterus. The occurrence of some elasmobranchs of conservation concern, such asSquatina aculeata,Hexanchus griseus,Squalus blainvilleandGaleus melastomus, was noteworthy. Differences in fish assemblage composition were observed between the Aceste Seamount and the other sites and especially between the two bathymetric ranges. The fish distribution pattern showed significant relationships with bottom slope and some substrate types. A large occurrence of lost fishing gear characterized the sites closest to the coast (the Marettimo Banks and the Scuso Seamount), providing, along with scanty observations of commercially important fishes, evidence of heavy fishing activities. The adoption of conservation and management actions in the investigated seamounts and banks, such as their inclusion in the Natura 2000 network, would be very helpful to protect some threatened elasmobranchs and restore valuable deep-sea habitats.
Without more theory, psychology will be a headless rider
Authors: Hensel Witold M. , Miłkowski Marcin , Nowakowski Przemysław 
Published: February 2022

AbstractWe argue that Yarkoni's proposed solutions to the generalizability crisis are half-measures because he does not recognize that the crisis arises from investigators' underappreciation of the roles of theory in experimental research. Rather than embracing qualitative analysis, the research community should make an effort to develop better theories and work toward consistently incorporating theoretical results into experimental practice.
We need to think more about how we conduct research
Authors: Gigerenzer Gerd 
Published: February 2022

AbstractResearch practice is too often shaped by routines rather than reflection. The routine of sampling subjects, but not stimuli, is a case in point, leading to unwarranted generalizations. It likely originated out of administrative rather than scientific concerns. The routine of sampling subjects and testing their averages for significance is reinforced by delusions about its meaningfulness, including the replicability delusion.
There is no generalizability crisis
Authors: Lakens Daniël , Uygun Tunç Duygu , Necip Tunç Mehmet 
Published: February 2022

AbstractFalsificationist and confirmationist approaches provide two well-established ways of evaluating generalizability. Yarkoni rejects both and invents a third approach we call neo-operationalism. His proposal cannot work for the hypothetical concepts psychologists use, because the universe of operationalizations is impossible to define, and hypothetical concepts cannot be reduced to their operationalizations. We conclude that he is wrong in his generalizability-crisis diagnosis.
Citizen science can help to alleviate the generalizability crisis
Authors: Hilton Courtney B. , Mehr Samuel A. 
Published: February 2022

AbstractImproving generalization in psychology will require more expansive data collection to fuel more expansive statistical models, beyond the scale of traditional lab research. We argue that citizen science is uniquely positioned to scale up data collection and, that in spite of certain limitations, can help to alleviate the generalizability crisis.
Addressing a crisis of generalizability with large-scale construct validation
Authors: Flake Jessica Kay , Luong Raymond , Shaw Mairead 
Published: February 2022

AbstractBecause of the misspecification of models and specificity of operationalizations, many studies produce claims of limited utility. We suggest a path forward that requires taking a few steps back. Researchers can retool large-scale replications to conduct the descriptive research which assesses the generalizability of constructs. Large-scale construct validation is feasible and a necessary next step in addressing the generalizability crisis.
The cost of crisis in clinical psychological science
Authors: Grubbs Joshua B. 
Published: February 2022

AbstractYarkoni has argued that psychology is facing a generalizability crisis, but the real cost of this crisis is obscured by a focus on topics from psychology's most academic subfields. Psychology is also filled with applied subfields, and it is within those subfields – especially clinical science – where the cost of a generalizability crisis will be most severe.
Disentangling paradigm and method can help bring qualitative research to post-positivist psychology and address the generalizability crisis
Authors: Syed Moin , McLean Kate C. 
Published: February 2022

AbstractFor decades, psychological research has heavily favored quantitative over qualitative methods. One reason for this imbalance is the perception that quantitative methods follow from a post-positivist paradigm, which guides mainstream psychology, whereas qualitative methods follow from a constructivist paradigm. However, methods and paradigms are independent, and embracing qualitative methods within mainstream psychology is one way of addressing the generalizability crisis.
Observing effects in various contexts won't give us general psychological theories
Authors: Donkin Chris , Szollosi Aba , Bramley Neil R. 
Published: February 2022

AbstractGeneralization does not come from repeatedly observing phenomena in numerous settings, but from theories explaining what is general in those phenomena. Expecting future behavior to look like past observations is especially problematic in psychology, where behaviors change when people's knowledge changes. Psychology should thus focus on theories of people's capacity to create and apply new representations of their environments.
Generalizability challenges in applied psychological and organizational research and practice
Authors: Wiernik Brenton M. , Raghavan Mukhunth , Allan Tyler , Denison Alex J. 
Published: February 2022

AbstractYarkoni highlights patterns of overgeneralization in psychology research. In this comment, we note that such challenges also pertain to applied psychological and organizational research and practice. We use two examples – cross-cultural generalizability and implicit bias training – to illustrate common practices of overgeneralization from narrow research samples to broader operational populations. We conclude with recommendations for research and practice.
Understanding the Controversy: The Kerner Commission, The Harvest of American Racism, and the Dynamics of Incorporating Social Science with Public Policy
Authors: LOESSBERG RICK 
Published: February 2022

AbstractThe Kerner Commission’s report is regarded as one of the nation’s most important works on race. However, the earlier rejection of an internal staff paper (“The Harvest of American Racism”) because it was “too radical” left a “gaping hole” in the Commission’s plans (“Harvest,” which sought to use social science to explain why only some cities encountered rioting, was to have been the report’s “core chapter”) and caused a staff split that threatened its work. Much has been written about the challenges of incorporating social science and public policy with references about them being in separate worlds with different languages, schedules, values, etc. This article examines to what extent any of these challenges was present as “Harvest” was being written and reviewed. It then seeks to determine what influence any complicating factor may have had and what, if anything, could have been done to produce a different outcome.
The Politics of Clemency in the Early American Presidency: Power Inherited, Power Refashioned
Authors: HAYS BRADLEY D. 
Published: February 2022

AbstractThis article presents case studies of pardons in the presidencies of Washington, Adams, and Jefferson. In doing so, the article moves away from the idea in existing scholarship that pardons of the past were largely noble acts of statecraft, untouched by ideological, partisan, or personal political motivations. Instead, it develops an account of how and why these pardons should be understood as both enabling presidents to achieve certain political objectives and, simultaneously, operating in an inherited environment in which presidents used existing resources to legitimate their pardons. In so doing, presidents refashioned those inherited resources and, thereby, created new resources for future presidents. The picture that emerges is of pardons as both sources of political innovation and political constraint.
Don't Go Chasing Waterfalls: Against Hayward's “Utility Cascades”
Authors: Doody Ryan 
Published: February 2022

AbstractIn his article “Utility Cascades”, Max Khan Hayward argues that act-utilitarians should sometimes either ignore evidence about the effectiveness of their actions or fail to apportion their support to an action's effectiveness. His conclusions are said to have particular significance for the effective altruism movement, which centers seeking and being guided by evidence. Hayward's argument is that act-utilitarians are vulnerable to succumbing to “utility cascades”, that these cascades function to frustrate the ultimate goals of act-utilitarians, and that one apposite way to avoid them is by “ostriching”: ignoring relevant evidence. If true, this conclusion would have remarkable consequences for act-utilitarianism and the effective altruism movement. However, Hayward is mistaken – albeit in an interesting way and with broader significance for moral philosophy. His argument trades on a subtle mischaracterization of act-utilitarianism. Act-utilitarians are not especially vulnerable to utility cascades (or at least not objectionably so), and they shouldn't ostrich.
HPPD-resistant cotton response to isoxaflutole applied preemergence and postemergence
Authors: Joyner Joshua D. , Cahoon Charles W. , Everman Wesley J. , Collins Guy D. , Taylor Zachary R. , Blythe Andrew C. 
Published: February 2022

AbstractStudies were conducted in 2019 and 2020 in Lewiston, NC, to determine the crop response of 4-hydroxyphenylpyrivate dioxygenase (HPPD)-resistant cotton to isoxaflutole (IFT) and other cotton herbicides as part of a cotton weed management program that included herbicides applied preemergence, early postemergence (EPOST), and mid-postemergence (MPOST). IFT was applied PRE at 105 g ha−1alone and in various combinations with acetochlor, diuron, fluometuron, fluridone, fomesafen, pendimethalin, and pyrithiobac. EPOST treatments included IFT at 53 or 105 g ha−1alone or in combination with glyphosate or glufosinate, or dimethenamid-P+ glufosinate. Glyphosate + glufosinate was applied MPOST to all treatments except the nontreated control. Cotton injury from IFT applied PRE was minimal (0% to 3%). Injury following EPOST application of dimethenamid-P+ glufosinate ranged from 3% to 5% and 6% to 9% in 2019 and 2020, respectively. In both years, injury from IFT applied PRE followed by IFT applied EPOST never exceeded injury from IFT applied PRE followed by dimethenamid-P+ glufosinate. Isoxaflutole applied PRE followed by IFT applied EPOST at 105 g ha−1resulted in 0% to 2% cotton injury, indicating that IFT can be applied either PRE or EPOST with minimal risk to cotton. Late-season cotton height and cotton lint yield were not affected by any herbicide treatment. The experimental HPPD-resistant cotton cultivar was minimally injured by IFT applied PRE and EPOST, it tolerated standard cotton herbicides, and yield loss was not observed. Given these results, HPPD-resistant cotton and IFT may be integrated into cotton weed management systems with minimal risk for cotton injury and provide an additional effective mechanism of action for managing troublesome weeds in cotton.
Risikofaktoren für und Stabilität einer Persönlichkeitsstörung vom Jugendalter bis ins junge Erwachsenenalter in einer Hochrisikopopulation
Authors: d’Huart Delfine , Bürgin David , Seker Süheyla , Birkhölzer Marc , Jenkel Nils , Boonmann Cyril , Fegert Jörg M. , Schmid Marc , Schmeck Klaus 
Published: February 2022

Zusammenfassung. Theoretischer Hintergrund: Studien zeigen, dass Persönlichkeitsstörungen (PS) weniger stabil und bei einer frühzeitigen Erkennung gut behandelbar sind. Fragestellung: Ziel dieser Studie ist, 1) die Prävalenz von PS bei ehemalig fremdplatzierten jungen Erwachsenen zu beschreiben, 2) die kategoriale Stabilität von PS vom Jugendalter bis ins junge Erwachsenenalter zu bestimmen und 3) prospektive Risikofaktoren für eine PS im Erwachsenenalter zu identifizieren. Methoden: 180 ehemalig fremdplatzierte junge Erwachsene ( M = 26.3 Jahre) aus einer schweizweiten Längsschnittstudie wurden untersucht. Ergebnisse: 35 % der Teilnehmenden wiesen eine PS auf. Die kategoriale Stabilität belief sich auf 47 %. Folgende Risikofaktoren für eine PS im Erwachsenenalter wurden identifiziert: vorangehende PS, psychopathische Persönlichkeitszüge, Substanzmissbrauch, emotionale Vernachlässigung, kumulierte Misshandlungserfahrungen und Deliktschwere. Diskussion und Schlussfolgerung: Die kategoriale Stabilität irgendeiner PS in dieser Stichprobe gilt als mittelgradig. Dies unterstreicht die Notwendigkeit, PS nicht mehr mit einem lebenslangen, unveränderbaren Schicksal gleichzusetzen. Das Erkennen möglicher Risikofaktoren ist eine wichtige Voraussetzung, um individuelle Behandlungsmöglichkeiten zu gewährleisten und einer Chronifizierung entgegenzuwirken.
Coseismic and Postseismic Fault Kinematics of the July 22, 2020, Nima (Tibet) Ms6.6 Earthquake: Implications of the Forming Mechanism of the Active N‐S‐Trending Grabens in Qiangtang, Tibet
Authors: Gao Hua , Liao Mingsheng , Liang Xiao , Feng Guangcai , Wang Genhou 
Published: February 2022

AbstractThe N‐S‐trending grabens, the most prominent active structures in the Tibetan plateau, contain important information about the evolution and deformation mechanism of the plateau. The Ms6.6 earthquake that occurred in Nima, Qiangtang on July 22, 2020, provides an opportunity to investigate the kinematics of the grabens. Here, we use field survey and interferometric synthetic aperture radar to study the structural style, coseismic and postseismic deformation, fault slip, and stress changes of the Nima earthquake. The N‐S‐trending Qomo Ri graben (QRG) and the normal faults on the east and west sides are kinematically correlated with the NE‐trending sinistral Jiangaizangbu River and West Yibug Caka faults. The QRG is characterized by an extensional strike‐slip duplex and negative flower structure. The maximum coseismic deformation of the Nima earthquake is 29.4 cm in the line‐of‐sight direction observed by Sentinel‐1 ascending images. The coseismic slip model demonstrates that the NE20–30°‐striking fault caused the Nima earthquake has a maximum slip of 1.39 m and a main slip area at 4–12 km depth. The seismological fault may transit from a moderately dipping normal fault near the surface to a steeper strike‐slip fault at depth. Obvious postseismic deformation was observed in the stress‐enhancement area. The afterslip model shows that the mainshock fault is correlated with parallel normal faults to its west. We infer that the QRG was formed by local E‐W‐trending extension at the joints of the left‐stepping sinistral fault system, and the active normal faulting in the Qiangtang block favors stress localization.
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis
Authors: Zhang Weifeng , Li Gaocai , Luo Rongjin , Lei Jie , Song Yu , Wang Bingjin , Ma Liang , Liao Zhiwei , Ke Wencan , Liu Hui , Hua Wenbin , Zhao Kangcheng , Feng Xiaobo , Wu Xinghuo , Zhang Yukun , Wang Kun , Yang Cao 
Published: February 2022

AbstractLow back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc (IVD) degeneration, characterized by progressive nucleus pulposus (NP) cell death and the development of an inflammatory microenvironment in NP tissue. Excessively accumulated cytosolic DNA acts as a damage-associated molecular pattern (DAMP) that is monitored by the cGAS-STING axis to trigger the immune response in many degenerative diseases. NLRP3 inflammasome-dependent pyroptosis is a type of inflammatory programmed death that promotes a chronic inflammatory response and tissue degeneration. However, the relationship between the cGAS-STING axis and NLRP3 inflammasome-induced pyroptosis in the pathogenesis of IVD degeneration remains unclear. Here, we used magnetic resonance imaging (MRI) and histopathology to demonstrate that cGAS, STING, and NLRP3 are associated with the degree of IVD degeneration. Oxidative stress induced cGAS-STING axis activation and NLRP3 inflammasome-mediated pyroptosis in a STING-dependent manner in human NP cells. Interestingly, the canonical morphological and functional characteristics of mitochondrial permeability transition pore (mPTP) opening with the cytosolic escape of mitochondrial DNA (mtDNA) were observed in human NP cells under oxidative stress. Furthermore, the administration of a specific pharmacological inhibitor of mPTP and self-mtDNA cytosolic leakage effectively reduced NLRP3 inflammasome-mediated pyroptotic NP cell death and microenvironmental inflammation in vitro and degenerative progression in a rat disc needle puncture model. Collectively, these data highlight the critical roles of the cGAS-STING-NLRP3 axis and pyroptosis in the progression of IVD degeneration and provide promising therapeutic approaches for discogenic LBP.
Central obesity is selectively associated with cerebral gray matter atrophy in 15,634 subjects in the UK Biobank
Authors: Pflanz Chris-Patrick , Tozer Daniel J. , Harshfield Eric L. , Tay Jonathan , Farooqi Sadaf , Markus Hugh S. 
Published: February 2022

Abstract
Background
Obesity is a risk factor for both cardiovascular disease and dementia, but the mechanisms underlying this association are not fully understood. We examined associations between obesity, including estimates of central obesity using different modalities, with brain gray matter (GM) volume in the UK Biobank, a large population-based cohort study.

Methods
To determine relationships between obesity and the brain we used brain MRI, abdominal MRI, dual-energy X-ray absorptiometry (DXA), and bioelectric whole-body impedance. We determined whether obesity was associated with any change in brain gray matter (GM) and white matter (WM) volumes, and brain network efficiency derived from the structural connectome (wiring of the brain) as determined from diffusion-tensor MRI tractography. Using Waist-Hip Ratio (WHR), abdominal MRI and DXA we determined whether any associations were primarily with central rather than peripheral obesity, and whether associations were mediated by known cardiovascular risk factors. We analyzed brain MRI data from 15,634.

Results
We found that central obesity, was associated with decreased GM volume (anthropometric data: p = 6.7 × 10−16, DXA: p = 8.3 × 10−81, abdominal MRI: p = 0.0006). Regional associations were found between central obesity and with specific GM subcortical nuclei (thalamus, caudate, pallidum, nucleus accumbens). In contrast, no associations were found with WM volume or structure, or brain network efficiency. The effects of central obesity on GM volume were not mediated by C-reactive protein or blood pressure, glucose, lipids.

Conclusions
Central body-fat distribution rather than the overall body-fat percentage is associated with gray matter changes in people with obesity. Further work is required to identify the factors that mediate the association between central obesity and GM atrophy.