bluuebunny/crossref_metadata_2025_split huggingface dataset:
The game of Hex, n-dimensional chessboard and Fixed Point Theorem
Authors: Turzański Marian , Ziajor Grzegorz 
Published: December 2022

Abstract
The main result of this paper is the algorithmic proof of n-dimensional Steinhaus’ chessboard theorem (as formulated in [12]). Our theorem implies Poincar´e Theorem [8] [7] which is equivalent to the Brouwer Fixed-Point Theorem
QSAR of SARS-CoV-2 Main Protease Inhibitors Utilizing Theoretical Molecular
Descriptors
Authors: Nandi Sisir , Kumar Mohit , Saxena Anil Kumar 
Published: December 2022

Background:
COVID-19 is caused by a novel strain of severe acute respiratory syndrome
coronaviruses (SARS-CoV-2). It has claimed casualties around the world since the end of 2019 due to its
high virulence and quick multiplicity in the human body. Hence, there has been a requirement to develop
effective remedial measures to mitigate the mortality. Scientists have been able to develop corona
vaccines to provide immunity, but there are no specific small-molecule chemotherapeutics to combat the
novel coronavirus which has spread to the whole world due to its contagiousness. In the viral genome
exploration, it has been found that the main protease, also known as chymotrypsin-like cysteine protease
([Mpro] or 3C-like protease [3CLpro]) is responsible for the novel coronavirus replication, transcription,
and host immunity destruction.

Objectives:
Therefore, the main protease has been selected as one of the major targets for the design of
new inhibitors. The protein crystallographic and molecular docking studies on SARS-CoV-2 Mpro inhibitors and some quantitative structure-activity relationship (QSAR) studies have been carried out on SARSCoV main protease inhibitors to get some lead molecules for SARS-CoV-2 inhibition. However, there is
hardly any QSAR done on the diverse data of SARS-CoV-2 main protease inhibitors. In view of it, QSAR
studies have been attempted on SARS-CoV-2 Mpro inhibitors utilizing theoretical molecular descriptors
solely computed from the structures of novel corona viral main protease inhibitors.

Methods:
Methods: As the number of structural descriptors is more than the observations, a genetic algorithm coupled with multiple linear methods has been applied for the development of QSAR models taking diverse
SARS-CoV-2 Mpro inhibitors.

Results:
The developed best QSAR model showing R2
, Q2
Loo, and R2
pred values of 0.7389, 0.6666, and
0.6453 respectively has been further validated on an external data set where a good correlation (r = 0.787)
has been found.

Conclusion:
Therefore, this model may be useful for the design of new SARS-CoV-2 main protease inhibitors.
Internet of Medical Things – The Future of Healthcare
Authors: Wal Pranay , Wal Ankita , Verma Neha , Karunakakaran Rohini , Kapoor Anupriya 
Published: December 2022

Background:
The Internet of Medical Things (IoMT) is now being connected to medical equipment to make patients more comfortable, offer better and more affordable health care options, and make it easier for people to get good care in the comfort of their own homes.

Objective:
The primary purpose of this study is to highlight the architecture and use of IoMT (Internet of Medical Things) technology in the healthcare system.

Methods:
Several sources were used to acquire the material, including review articles published in various journals that had keywords such as, Internet of Medical Things, Wireless Fidelity, Remote Healthcare Monitoring (RHM), Point-of-care testing (POCT), and Sensors.

Results:
IoMT has succeeded in lowering both the cost of digital healthcare systems and the amount of energy they use. Sensors are used to measure a wide range of things, from physiological to emotional responses. They can be used to predict illness before it happens.

Conclusion:
The term “Internet of Medical Things” refers to the broad adoption of healthcare solutions that may be provided in the home. Making such systems intelligent and efficient for timely prediction of important illnesses has the potential to save millions of lives while decreasing the burden on conventional healthcare institutions, such as hospitals. patients and physicians may now access real-time data due to advancements in IoM.
"Why must fireflies die so young?" The Picturesque of Caution in the Works of Studio Ghibli
Authors: Roy Samragngi 
Published: December 2022

As opposed to most contemporary usage of the word “picturesque” – which is generally taken to mean visually attractive in a quaint or charming way, or else something that resembles a picture – William Gilpin introduced this term to the English cultural debate in 1792. Gilpin used “picturesque” to typify an aesthetic ideal wherein roughness, raggedness, and ruins would be privileged over smoothness, symmetry and perfection. Over time, his conceptualization of “the picturesque” led to a celebration of disorder, decay, and ruin, a kind of glorification of violence also familiar to the Gothic romances of the late eighteenth and early nineteenth centuries. However, following the unimaginable havoc and mass destruction caused by the two world wars, ruins and images of ruins started to be viewed very differently. This paper seeks to explore how the picturesque mode has been used as an instrument of caution in the works of Studio Ghibli, spearheaded by two creative artists and directors, Hayao Miyazaki and Takahata Isao, who have experienced the horrors of WWII firsthand in their own childhoods. This paper specifically looks at two famous anime feature films produced by Studio Ghibli – Grave of the Fireflies (1988) and Howl's Moving Castle (2004) – that deal with the impacts of war and convey strong anti-war messages by uniquely employing the picturesque mode of representation.
Anime Convention Attendance in Response to Covid-19
Authors: Alberto Maria , Tringali Billy 
Published: December 2022

The following report is meant to be paired with the dataset collected through the “Anime Conventions and COVID-19” survey. Designed by Maria K. Alberto and Billy Tringali, this survey collected participants’ thoughts about their involvement in and perception of anime conventions before, during, and after the Covid-19 pandemic lockdowns. Both the dataset and associated survey questions can be found in the supplemental files paired with this report, or downloaded through the Hive, the University of Utah’s Research Data Repository. See: “Dataset for: Survey of Anime Convention Attendance in Response to Covid-19” at https://hive.utah.edu/concern/datasets/qj72p722r
Contemporary Trends in Dental Implants
Authors: Jain Sanyam , Soni Sani , Lodhi Shivani , Khan Rubeena , Jain Anushree , Khare Basant , Thakur Bhupendra Singh , Jain Prateek Kumar 
Published: December 2022

A high number of patients have one or more missing tooth and it is estimated that one in four world subjects over the age of 74 have lost all their natural teeth. Many options exist to replace missing teeth but dental implants have become one of the most used biomaterial to replace one (or more) missing tooth over the last decades. Therefore, the use of dental implants is also a common practice. Although research on dental implant de­signs, materials and techniques has increased in the past few years and is expected to expand in the future, there is still a lot of work involved in the use of better biomaterials, implant design, surface modification and functionalization of surfaces to improve the long-term outcomes of the treatment. This paper provides a brief history and evolution of dental implants. It also describes the types of implants that have been developed, and the parameters that are presently used in the design of dental implants. Finally, it describes the trends that are employed to improve dental implant surfaces, and current technologies used for the analysis and design of the implants.
Keywords: Dental implants, History, Design, Surfaces, Osseointegration, Biopolymers.
Relationships Between the Cumulative Incidences of Long-term Complications in Type 1 Diabetes: The DCCT/EDIC Study
Authors: Bebu Ionut , Braffett Barbara H. , de Boer Ian H. , Aiello Lloyd P. , Bantle John P. , Lorenzi Gayle M. , Herman William H. , Gubitosi-Klug Rose A. , Perkins Bruce A. , Lachin John M. , Molitch Mark E. 
Published: December 2022

OBJECTIVE
To describe the relationships between the cumulative incidences of long-term complications in individuals with type 1 diabetes (T1D) and assess whether observed associations are independent of age, duration of diabetes, and glycemic levels.

METHODS
Proliferative diabetic retinopathy (PDR), clinically significant macular edema (CSME), reduced estimated glomerular filtration rate (eGFR), amputations, cardiovascular disease (CVD), and mortality were assessed in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study over ∼30 years.

RESEARCH DESIGN AND RESULTS
The cumulative incidence of complications ranged from 3% (amputations) to 37% (CSME). There were large differences in the cumulative incidence of PDR between participants with versus without prior CSME (66% vs. 15%), reduced eGFR (59% vs. 29%), and amputation (68% vs. 32%); reduced eGFR with or without prior PDR (25% vs. 9%), amputation (48% vs. 13%), and CVD (30% vs. 11%); CVD with or without prior reduced eGFR (37% vs. 14%) and amputation (50% vs. 16%); and mortality with or without prior reduced eGFR (22% vs. 9%), amputation (35% vs. 8%), and CVD (25% vs. 8%). Adjusted for age, duration of T1D, and mean updated HbA1c, the complications and associations with higher risk included PDR with CSME (hazard ratio [HR] 1.88; 95% CI 1.42, 2.50), reduced eGFR (HR 1.41; 95% CI 1.01, 1.97), and CVD (HR 1.43; 95% CI 1.06, 1.92); CSME with higher risk of PDR (HR 3.94; 95% CI 3.18 4.89), reduced eGFR (HR 1.49; 95% CI 1.10, 2.01), and CVD (HR 1.35; 95% CI 1.03, 1.78); reduced eGFR with higher risk of CVD (HR 2.09; 95% CI 1.44, 3.03), and death (HR 3.40; 95% CI 2.35, 4.92); amputation(s) with death (HR 2.97; 95% CI 1.70, 2.90); and CVD with reduced eGFR (HR 1.59; 95% CI 1.08, 2.34) and death (HR 1.95; 95% CI 1.32, 2.90).

CONCLUSIONS
Long-term micro- and macrovascular complications and mortality are highly correlated. Age, diabetes duration, and glycemic levels do not completely explain these associations.
DPP-4 inhibitor and sulfonylurea differentially reverse type 2 diabetes-induced blood-brain barrier leakage and normalise capillary pericyte coverage
Authors: Elabi Osama F. , Karampatsi Dimitra , Vercalsteren Ellen , Lietzau Grazyna , Nystrom Thomas , Klein Thomas , Darsalia Vladimer , Patrone Cesare , Paul Gesine 
Published: December 2022

<p>Microvascular pathology in the brain is one of the suggested mechanisms underlying the increased incidence and progression of neurodegenerative diseases in people with type 2 diabetes (T2D). While accumulating data suggest a neuroprotective effect of antidiabetics, the underlying mechanisms are unclear. </p>
<p>Here, we investigated whether two clinically used antidiabetics, the dipeptidyl peptidase-4 inhibitors (DPP-4i) linagliptin and the sulfonylurea glimepiride, restore T2D-induced brain vascular pathology. Microvascular pathology was examined in the striatum of mice fed for 12 months with either normal chow diet or a high-fat diet (HFD) to induce T2D. A subgroup of HFD-fed mice was treated with either linagliptin or glimepiride for 3 months before the sacrifice. </p>
<p>We demonstrate that T2D caused leakage of the blood-brain barrier (BBB), induced angiogenesis and reduced pericyte coverage of microvessels. However, linagliptin and glimepiride recovered the BBB integrity and restored the pericyte coverage differentially. Linagliptin normalised T2D-induced angiogenesis and restored pericyte coverage. In contrast, glimepiride enhanced T2D-induced angiogenesis and increased pericyte density, resulting in proper vascular coverage. Interestingly, glimepiride reduced microglial activation, increased microglial-vascular interaction, and increased collagen IV density. </p>
<p>This study provides evidence that both DPP-4 inhibition and sulfonylurea reverse T2D-induced BBB leakage which may contribute to the antidiabetic neurorestorative effects. </p>
The Effect of Varying Dentin Chroma and Enamel Thickness on the Color of A2 Double-layered Resin Composite
Authors: Ismail EH , Dawson DV , Vidal CMP , Skiff FN , Brogden K , Maia RR 
Published: December 2022

SUMMARY

Objectives
To evaluate chroma (C*) and overall color of double-layered (DL) resin composite (RC) restorations with various dentin shades and enamel thicknesses.

Methods
Enamel specimens were fabricated using custom-made molds to replicate VITA shade tabs with variant enamel thicknesses (0.5, 0.7, and 1.0 mm) (n=7) from two RC: Clearfil-Majesty (CM) shade (A2), and Vit-l-escence (VL), shade (pearl-neutral). Dentin specimens (shades A1, A2, and A3) were fabricated using custom molds corresponding to the enamel molds. Each enamel specimen was paired with three different dentin specimens. L*a*b* parameters were measured with VITA Easyshade-V. Color difference between DL specimens and the A2 VITA shade tab were calculated with the CIEDE2000 formula. Relationships among enamel thickness, ΔE00, C* of dentin layer, C* of DL, and change in chroma were assessed by Spearman rank correlations. ΔE00 was compared among groups using one-way analysis of variance with Tukey post-hoc adjustment for all possible pairwise group comparisons (experiment-wise α=0.05).

Results
There was no statistical difference among C* of DL specimens (p=0.65, 0.53) for CM and VL, respectively. Combinations of enamel thickness/dentin shade had a significant difference in ΔE00 (p&gt;0.05). No significant correlation was observed among enamel thickness and C* of dentin, and C* of the DL (p&gt;0.05). Significant correlations were observed between ΔE00 of the VL DL and C* DL (r=−0.8, p&lt;0.001); and ΔE00 of CM DL and enamel thickness (r=0.5, p&lt;0.001).

Conclusions
Enamel thickness did not affect C* of the dentin layer. Unlike VL RC, variations in dentin shades with CM produced a closer match to the A2 shade tab. Enamel is recommended to be 0.7 mm or less.
PEMBUATAN DEKORASI RUMAH PENGANTIN DI DWIKA DEKORASI DESA SELAT, BULELENG, BALI
Authors: Suarmawan Putu Yudik , Koriawan Gede Eka Harsanan , Rediasa I Nyoman 
Published: December 2022

This article contains part of the thesis entitled "Making Bridal Home Decorations in Dwika Decorating Selat Village, Buleleng Bali" qualitative research with the objectives: (1) To describe the existence of bridal house decorations in Dwika Decorating Selat Village, Buleleng, Bali. (2) To find out the materials and tools used in making decorations at the gate of the bride's house (3) To understand and know the process of making decorations for the gate of the bridal house and (4) To find out the designs and motifs used in decorating the gates of the bridal house in Dwika Decorating Selat Village, Buleleng, Bali. The data was obtained through the stages of observation and interviews with the business owner of Deika Decor then the data was processed using the Sparadley model (1980) by analyzing the domain and taxonomy. , Bali . (2) the materials used are teak wood, coconut leaves (young, old, and dry), rope (bamboo rope, macrame rope), paint, wire, and nails, while for scissors, saws, knives (large and small) , pliers, tape measure, hammer, kacip (shooter blade and ordinary kacip), and brush. (3) Making decorations for the gate of the bride's house, namely the ordering process, making the frame, making hisan, and installing it. (4) designs and decorations are of two types, namely traditional and modern designs.
Keywords: Decoration, Bridal House, Straits Village.
KAJIAN PROSES DAN NILAI ESTETIK BATIK TULIS DI RUMAH “BATIK RATO WMS (WIRAUSAHAWAN MUDA SUMENEP)” KABUPATEN SUMENEP
Authors: Fatih Yulia Nurul , Sudarmawan Agus , Ardana I Gusti Ngurah Sura 
Published: December 2022

The research that carried out in “Batik Rato WMS” house at sub-regency Sumenep is aimed to Describing aesthetic value in _Batik Tulis_ from “Batik Rato WMS” house. Batik Rato WMS is the batik from Sumenep, Madura-East Java. The subjects of this research are people who are resource persons and Batik Rato WMS craftsmen Jl. Dr. Soetomo, Lingkungan Delama, Pajagalan, Kota Sumenep, Kabupaten Sumenep, Jawa Timur 69416. This research was conducting by using a qualitative type with a descriptive approach. The research focused on the motifs and colors of Sumenep batik. The data in this study were obtained by observation, interviews, and documentation.

The following research finding are, as follows: The process of batik making are preparation and process of making. The motifs and colors of Batik Rato WMS through Monroe Beardsley’s aesthetic approach have the value of three aesthetic elements, such as integrity, complexity and sincerity. (1) Unity is found in visual elements that are distilled based on the main motif, combined with guri’, as well as elements of local culture in Sumenep such as the winged horse, Keris Keraton, Kerapan Sape, Blarak and flowers with contrasting and bright colors. (2) The complexity shown in the number of ornaments in each sheet of cloth, which is arranged very finely and repeatedly in expressive way. The variations of the supporting ornaments are quite complicated, this is due to the effort to display the keris element on each sheet of batik cloth which is located on the sleeve as a characteristic of this batik. Batik Rato WMS coloring required time and accuracy in the coloring process with varied motifs and ornaments. (3) The element of earnestness in the motifs and colors found in the shape character of the distinctive motif so that it describes locality of the area and the large motif by considering the quality of the various properties that exist in the value/philosophy, which defined as tenacity, patience and perseverance.
Keywords: Aesthetic value, motif, color, Batik Rato WMS
THE DEVELOPMENT OF OGOH-OGOH MAKING WITH KINETIC ART’S TECHNOLOGY IN DENPASAR CITY
Authors: Ardana I Gusti Nengah Sura , Sudita I Ketut 
Published: December 2022

Ogoh-Ogoh is a three-dimensional kind of sculpture made at the time of pengrupukan in Bali, which is very closely related to the celebration of the Nyepi day of the Hindus in Bali as the new year, which comes once a year. In welcoming this celebration, there is something called tawur sange or the pecaruan ceremony, which means purifying the earth, carried out the day before the Nyepi celebration. The purpose of this celebration is to neutralize the forces of power of the negative that often interfere with human life, known as Bhuta Kala. It is what in Somia (neutralize) to be a good force (positive) and become the power of God.
During this celebration, ogoh-ogoh are made that resemble the shape of Bhuta Kala or negative power whose shape is made very scary according to the imagination of the artists/young people who make it. The shape and appearance of the ogoh-ogoh today have progressed very rapidly. The development of making ogoh-ogoh today is very rapid and has experienced a very amazing increase, and it is because young people (yuwana) are developing creativity and innovation in making ogoh - ogoh. The innovation made is by incorporating elements of technology, namely Kinetic Art technology, into the manufacture of ogoh-ogoh, so that the ogoh-ogoh seem alive because they move.
This research was conducted in Denpasar City with qualitative methods in data collection and has the purpose and benefit of knowing in depth about the development of ogoh-ogoh in the present.
Keywords : Development, Ogoh - Ogoh, Kinetik Art
Pelatihan goal Setting untuk Meningkatkan Motivasi Belajar Siswa SMK di Masa Pandemi Covid 19
Authors: Agustina Navi 
Published: December 2022

Kegiatan Pengabdian Masyarakat ini bertujuan untuk mengetahui pengaruh pelatihan Goal setting pada motivasi belajar siswa SMK Negri Singgahan di masa Pandemi Covid 19 . Subjek dalam penelitian ini adalah 15 siswa SMK di Singgahan Tuban yang berdasarkan rekomendasi Guru setempat memiliki motivasi belajar yang rendah. Pengumpulan data dilakukan dengan menggunakan skala motivasi belajar dan observasi serta lembar Kerja. Skala Motivasi menggunakan skala Likert untuk mengukur Motivasi siswa sebelum dan sesudah pelatihan, observasi dilakukan saat pelatihan berlangsung, dan lembar kerja digunakan dalam materi mengenal diri dan goal setting. Pelatihan ini terdiri dari 4 sesi yaitu; 1.Mengenal Diri, 2. Inspirasi orang sukses, 3. Goal Setting dengan Metode Smart, dan 4. Permainan melempar Bola.Analisis penelitian yang digunakan adalah analisis kuantitatif dan kualitatif. Analisis kuantitatif menggunakan SPSS 24.0 dengan Uji Mann Whitney U. Hasil dari Pelatihan ini menunjukan bahwa tidak ada perubahan motivasi belajar siswa yang signifikan setelah diberikan pelatihan goal setting dengan nilai signifikansinya 0,692 (p >0,05). Hal ini berarti, tidak ada peningkatan pada motivasi belajar siswa setelah diberikan pelatihan goal setting. Hasil analisis Kualitatif dapat memberikan penjelasan mengapa Pelatihan ini tidak signifikan meningkatkan motivasi belajar. Pada saat mengisi tujuan hidup 13 dari 15 siswa belum mampu mengisi dengan spesifik, dan terdapat kendala keterbatasan waktu untuk membantu siswa agar dapat menentukan tujuan hidup yang spesifik. Walaupun demikian, Pelatihan Goal Setting membantu siswa untuk mengenal diri dan konsep diri, menganalisis SWOT dan membuat strategi dalam menentukan target. Sebagai rokemendasi atau saran, maka Pelatihan Goal Setting secara daring membutuhkan pengkondisian yang lebih tepat,dan waktu yang lebih banyak.
Kinerja Pegawai Pasca Restrukturisasi pada Direktorat SMA Kementerian Pendidikan Kebudayaan Riset dan Teknologi
Authors: Kurnia Aulia Syafa , Mawar Mawar , Rahman Abdul 
Published: December 2022

This study aims to analyze the performance of employees of the Directorate of High Schools of the Ministry of Education, Culture, Research and Technology after the organizational restructuring. In this study, there is a problem, namely after the restructuring, the performance of employees of the Directorate of High School has not been fully optimal in working. This research uses employee performance theory according to Robbins, namely Quality, Quantity, Punctuality, Effectiveness, Independence and Work Commitment. The method used in this study is descriptive with a qualitative approach. This research was sourced from data from scientific journals, official websites, and supporting documents that describe the performance of employees at the Directorate of High Schools after the restructuring. The results showed that employee performance after restructuring was not optimal because employees were still being adjusted to the changes that occurred and there were still obstacles felt by employees in completing their work. However, the quality of performance provided for educational units (SMA) such as technical guidance and assistance services is good. The responsibility that employees have in completing their duties is good. However, there is still a low level of employee discipline in working hours.