bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depot- and Diabetes-Specific Differences in Norepinephrine- Mediated Adipose Tissue Angiogenesis, Vascular Tone, Collagen Deposition and Morphology in Obesity
Authors: Shen Lei , Dashwood Michael R , Casale Carlo , Orie Nelson N , Evans Ian M , Sufi Pratik , Gray Rosaire , Mohamed-Ali Vidya 
Published: March 2022

Abstract
Background
Norepinephrine (NE) is a known regulator of adipose tissue metabolism, angiogenesis, vasoconstriction and fibrosis. This may be through autocrine/paracrine effects on local resistance vessel function and morphology. The aims of this study were to investigate, in human subcutaneous and omental adipose tissue (SAT and OAT): NE synthesis, angiogenesis, NE-mediated arteriolar vasoconstriction, the induction of collagen gene expression and its deposition in non-diabetic versus diabetic obese subjects.
Methods
SAT and OAT from obese patients were used to investigate tissue NE content, tyrosine hydroxylase (TH) density, angiogenesis including capillary density, angiogenic capacity and angiogenic gene expression, NE-mediated arteriolar vasoconstriction and collagen deposition.
Results
In the non-diabetic group, NE concentration, TH immunoreactivity, angiogenesis and maximal vasoconstriction were significantly higher in OAT compared to SAT (p < 0.05). However, arterioles from OAT showed lower NE sensitivity compared to SAT (10− 8 M to 10− 7.5 M, p < 0.05). A depot-specific difference in collagen deposition was also observed, being greater in OAT than SAT. In the diabetic group, no significant depot-specific differences were seen in NE synthesis, angiogenesis, vasoconstriction or collagen deposition. SAT arterioles showed significantly lower sensitivity to NE (10− 8 M to 10− 7.5 M, p < 0.05) compared to the non-diabetic group.
Conclusion
SAT depot in non-diabetic obese patients exhibited relatively low NE synthesis, angiogenesis, tissue fibrosis and high vasoreactivity, due to preserved NE sensitivity. The local NE synthesis in OAT and diabetes desensitizes NE-induced vasoconstriction, and may also explain the greater tissue angiogenesis and fibrosis in these depots.
Tracking Population Status and Structure of Mediterranean Pen Shell Pinna Nobilis After a Mass Mortality Outbreak
Authors: Pensa Davide , Fianchini Alessandra , Grosso Luca , Ventura Daniele , Scardi Michele , Rakaj Arnold 
Published: March 2022

Abstract
The dramatic Mass Mortality Event, MME, of Pinna nobilis populations initially detected in 2016 in the western Mediterranean basin, has also spread rapidly to the central and eastern basin. Unfortunately, there is still a significant lack of information on the status and health of P. nobilis, since only a fragmentary picture of the mortality rate affecting these populations is available. Regarding the Italian coast, several surveys have given only localized or point-like views on the distribution of species and the effect of the MME. Therefore, for the first time, this study investigated P. nobilis densities, distribution and mortality in 164 surveys covering a total of 800 km along the southeast coast of Italy (Apulia region). The geographical scale of this investigation made it the largest ever conducted in Italy, and this was achieved through a rapid and standardized protocol. No live individuals were observed along the 92 km linear transects, allowing us to assess that the P. nobilis populations had totally collapsed, with a mortality rate of 100% in Apulia. The distributional pattern of the species showed a strong overlap with seagrass meadows on meso and macro geographical scale, however this was not the case on a micro scale. This result indicates that although there is a relationship between P. nobilis and seagrass meadows, it is not limited to the habitat patch but crosses the boundaries of seagrass. This observation led us to the conclusion that the distribution of P. nobilis shows a trophic link through the cross-boundary subsidy occurring from seagrass meadows to the nearby habitat, by means of the refractory detrital pathway.
Utilizing ferrorestorable polarization in energy storage ceramic capacitors
Authors: Matsuo Hiroki , Utsunomiya Masashi , Noguchi Yuji 
Published: March 2022

Abstract
A self-powered system with a long lifetime offers an opportunity to develop a next-generation, standalone Internet of Things. Ceramic capacitors are promising candidates for energy storage components because of their stability and fast charge/discharge capability. Even for state-of-the-art capacitors, the energy density needs to be increased markedly. Improving breakdown electric fields provides a potential solution, but operations at such high fields relying on unchanged dielectric permittivity sacrifice the lifetime to some degree. Here, we report a ferrorestorable polarization engineering capable of enhancing effective permittivity over twice. Our experiments and ab initio calculations demonstrate that a defect dipole composed of Cu3+ and oxygen vacancy in a prototypical ferroelectric BaTiO3 ceramic is coupled with spontaneous polarization. The resultant ferrorestorable polarization delivers an extraordinarily large effective relative permittivity beyond 7,000 with a high energy efficiency up to 89%. Our work paves the way to realizing efficient ceramic capacitors for self-powered applications.
Prognostic Factors Of Patients With Unexpected Pleural Dissemination During Thoracoscopic Surgery For Non-Small Cell Lung Cancer: A Retrospective Study
Authors: Liang Jin-xiao , Wei Wei-tian , Gao Wei , Yang Xun , Liu Jin-shi 
Published: March 2022

Abstract
Background: Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors with high degree of malignancy and early metastasis. A preoperative examination is undetectable when pleural dissemination of NSCLC occurs at an early stage, leading surgeons to detect pleural dissemination during surgery. However, there are few studies on the prognostic factors of NSCLC patients with pleural disseminated during surgery. Methods: We retrospectively analyzed 54 patients with NSCLC with pleural dissemination found during video-assisted thoracoscopic surgery to investigate the effects of clinical-pathological features, serum characteristics, surgical methods, and postoperative treatment on their prognosis. Results and conclusion: We found that squamous cell carcinoma (p=0.008), high level of serum GGT (p=0.046) and CA199 (p=0.001) were significantly correlated with the poor prognosis of NSCLC with pleural dissemination. Resection of the primary tumor was not necessary for patients who could receive targeted therapy after surgery, while for patients who receive chemotherapy after surgery, resection of the primary tumor, especially lobectomy, could obtain a better prognosis. Targeted therapy is preferred if there is a driving gene mutation after the operation, and immunotherapy combined with chemotherapy can be selected if there is no mutation. These results can provide a clinical basis for prognosis judgment and treatment decision of NSCLC patients with pleural dissemination found during the operation.
18F-fluorodeoxyglucose Positron Emission Tomography/computed Tomography Comparison of Gastric Lymphoma and Gastric Carcinoma
Authors: Xu Qiaoling , Wu Najing , He Huihui , Du Xiaoqing , Wang Yanjuan , Lou Kequan , Chen Liping , Zhang Yu , Yu Chunjing 
Published: March 2022

Abstract
BackgroundThis study aimed to compare the characteristics of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in gastric lymphoma (GL) and gastric carcinoma (GC). Patients with newly diagnosed GL or GC who underwent 18F-FDG PET/CT prior to treatment were included in this study. The PET/CT features of gastric wall lesions, including FDG avidity, pattern, and intensity [maximal standard uptake value (SUVmax)] were reviewed and analyzed.ResultsA total of 68 patients with GL and 117 with GC were included in this study. Abnormal gastric FDG accumulation was found in 66 (97.05%) patients with GL and 109 (93.16%) patients with GC. Majority of the GL patients presented with type I and III lesions, whereas GC patients mainly with type II and III lesions. The SUVmax [14.89(6.56,22.12) vs 4.08(5.75,10.24), P<0.001) and SUVmax/THKmax (maximal thickness) [0.72(0.50,1,10) vs 0.39(0.28,0.64), P<0.000] were both higher in patients with GL when compared with GC. The SUVmax was higher in GL patients with DLBCL than in those with MALT (17.51±10.31 vs 4.97±2.92, P =0.0010) and higher in patients with advanced Lugano stage (II1/II2/IV) than in those with stage I (18.27±10.19 vs 9.92±9.22, P = 0.002). The ROC curve analysis suggested a better performance of SUVmax/THKmax in evaluating gastric lesions between GL and GC when compared to SUVmax alone.ConclusionsThe PET/CT features differed between GL and GC, and these can improve the evaluation of PET/CT of gastric wall lesions and help differentiate GL from GC.
In-Hospital Outcome of Stroke at a Divisional Hospital of Pakistan
Authors: Raheem Umar , Ahmed Mian Saad , Bibi Kalsoom 
Published: March 2022

Background: Stroke having two major types, is a clinical presentation which presents loss of brain function; risk factors & complications may vary and which ultimately can lead to death Objective: To determine stroke outcome and its association with factors and complications. Methods: Observational cross-sectional study, conducted from Nov 2015 to Aug 2016 at DHQ Teaching Hospital, KMU Institute of Medical Sciences, Kohat. A pre-designed questionnaire was adopted for data extraction. SPSS 25.0 was used; descriptive and inferential statistics were applied where needed Results: From 100 patients, male were 54% with mean age of 67.48±13.77 years, having 88% Ischemic stroke patients. Hypertension (79%) and family history (39%) were major risk factors while constipation (59%) and aspiration pneumonia (44%) were major complications with in-hospital mortality of 10%. The factors had a higher Prevalence Ratio (PR) for drug abuse (1.330), hypercholesterolemia (1.166), and hypertension (1.036) in ischemic stroke, while in hemorrhagic stroke PR was high for family history (1.918), heart diseases (1.173) and sedentary lifestyle (1.030). In complication, ischemic stroke had a higher PR for constipation (0.996), while hemorrhagic stroke had a higher PR for bed sores (3.286). The results shows an overall mortality of 10% only. Conclusion: The study concluded in-hospital mortality with ischemic stroke more common then hemorrhagic stroke. Hypertension and constipation were a prevalent risk factor and complication respectively. Family history, heart diseases, sedentary lifestyle and all complications were associated more with the hemorrhagic stroke while all other risk factors and no complications had a higher association with ischemic stroke.
Peripapillary Atrophy Segmentation and Classification Methodologies for
Glaucoma Image Detection: A Review
Authors: Kako Najdavan A. , Abdulazeez Adnan M. 
Published: March 2022

Abstract:
Information-based image processing and computer vision methods are utilized in several
healthcare organizations to diagnose diseases. The irregularities in the visual system are identified over
fundus images with a fundus camera. Among ophthalmology diseases, glaucoma is the most common
case leading to neurodegenerative illness. The unsuitable fluid pressure inside the eye within the visual
system is described as the major cause of those diseases. Glaucoma has no symptoms in the early stages,
and if it is not treated, it may result in total blindness. Diagnosing glaucoma at an early stage may
prevent permanent blindness. Manual inspection of the human eye may be a solution, but it depends on
the skills of the individuals involved. The diagnosis of glaucoma by applying a consolidation of computer
vision, artificial intelligence, and image processing can aid in the prevention and detection of
those diseases. In this review article, we aim to introduce numerous approaches based on peripapillary
atrophy segmentation and classification that can detect these diseases, as well as details regarding the
publicly available image benchmarks, datasets, and measurement of performance. The review article
highlights the research carried out on numerous available study models that objectively diagnose glaucoma
via peripapillary atrophy from the lowest level of feature extraction to the current direction based
on deep learning. The advantages and disadvantages of each method are addressed in detail, and tabular
descriptions are included to highlight the results of each category. Moreover, the frameworks of
each approach and fundus image datasets are provided. Our study would help in providing possible
future work directions to diagnose glaucoma.
Applications and Challenges in Healthcare Big Data: A Strategic Review
Authors: Khanna Deepanshu , Jindal Neeru , Singh Harpreet , Rana Prashant Singh 
Published: March 2022

Abstract:
Big data has been a topic of interest for many researchers and industries for the past few
decades. Due to the exponential growth of technology, a tremendous amount of data is generated every
minute. This article provides a strategic review of big data in the healthcare sector. In particular, this
article highlights various applications and issues faced by the healthcare industry using big data by
evaluating various journal articles between 2016 and 2021. Multiple issues related to data mining,
storing, analyzing, and sharing of big data in healthcare, briefly summarizing deep-learning-based tools
available for big data analytics, have been covered in this article. This article aims to benefit the research
community by summarizing various research tools and processes available today to manage big
data in healthcare.
A Review on Properties, Synthesis, Surface Functionalization and Application
of Nanodiamonds for Antimicrobial Activity
Authors: Tyagi Vandana , Chandra Amrish , Dhankhar Neelam , Tyagi Bhavna 
Published: March 2022

Abstract:
Diamond is a metastable carbon allotrope. Microdiamonds are monocrystalline diamonds
with particle sizes of less than 100 nm that have been explored over the last few decades. Nanodiamonds
are particularly appealing to provide a variety of possible applications due to their superior mechanical
and optical qualities, wide surface area, ease of bioconjugation, and high biocompatibility. In
recent years, NDs have gotten a lot of attention in nanomedicine, and some significant progress has
been made. The methods for creating various kinds of nanodiamonds are generalized, including detonation,
CVD, hydrothermal and High-Pressure, High-Temperature Microdiamond Milling procedures.
The characteristics, properties, synthesis, structure and surface functionalization, and applications of
nanodiamonds for antimicrobial activity are discussed in this review paper.
Feasibility and Acceptability of an Online WhatsApp Support Group on Breastfeeding: Protocol for a Randomized Controlled Trial
Authors: Lok Kris YW , Ko Rachel WT , Fan Heidi SL , Chau PH , Wong Janet YH , Wang MP , Tsang Vicky 
Published: March 2022

Background
Mobile health, the use of mobile technology in delivering health care, has been found to be effective in changing health behaviors, including improving breastfeeding practices in postpartum women. With the widespread use of smartphones and instant messaging apps in Hong Kong, instant messaging groups could be a useful channel for delivering breastfeeding peer support.

Objective
The aim of this paper is to study the feasibility and acceptability of an online instant messaging peer support group by trained peer counselors on improving breastfeeding outcome in primiparous women in Hong Kong.

Methods
A two-arm, assessor-blind, randomized controlled feasibility study will be conducted on 40 primiparous women with the intention to breastfeed. Participants are recruited from the antenatal obstetrics and gynecology clinic of a public hospital in Hong Kong and randomly assigned at a 1:1 ratio to either intervention or control group. The intervention group receives peer support in an online instant messaging group with trained peer counselors on top of standard care, whereas the control group receives standard care. Breastfeeding outcome will be assessed for 6 months post partum or until weaned. The breastfeeding status, the proportion and duration of exclusive and any breastfeeding in each group, and the self-efficacy and attitude of participants will be assessed. The feasibility and acceptability of the study would also be assessed in preparation for a full randomized controlled trial.

Results
This study (protocol version 1 dated January 5, 2021) has been reviewed and approved by the institutional review board of the University of Hong Kong, Hospital Authority Hong Kong West Cluster (reference UW 21-039), on January 26, 2021. Data collection is ongoing and expected to be completed in December 2021. The findings will be updated on clinical trial registry and disseminated in peer-reviewed journals.

Conclusions
This study aims to assess the feasibility and effectiveness of an online instant messaging peer support group in improving the breastfeeding outcome of primiparous women in Hong Kong. Its findings could inform the feasibility of a full-scale trial with this intervention design.

Trial Registration
ClinicalTrials.gov NCT04826796; https://clinicaltrials.gov/ct2/show/NCT04826796

International Registered Report Identifier (IRRID)
DERR1-10.2196/32338
Ontology-based Chatbot to Support Monitoring of Server Performance and Security By Rule-base
Authors: Ishlakhuddin Fauzan , SN Azhari 
Published: March 2022

The server is a computer program or a device that provides functionality for other programs or devices, called "clients". Generally, server computers have many resources that can be used by one or more clients through the network with specific permissions and requirements. Therefore, the server needs a monitoring system that can monitor server activity and notify if problems occur. This research focuses on developing a notification and question and answer system to connect the network admin with the monitoring system via chatbot. The developed chatbot can send notifications to the admin if an error occurs and can answer questions about the server's condition. The question and answer system developed implements natural language processing for Indonesian. The process of understanding questions is by classifying each word (token) based on language knowledge stored in the ontology. Then the classification results are processed by rule-base to produce conclusions to take monitoring data and compiled into answers. The test results show that the developed system can auto-notify if any problem in a server, and can answer questions by accuracy 95%.
Selection of the Best K-Gram Value on Modified Rabin-Karp Algorithm
Authors: Hidayat Wahyu , Utami Ema , Sunyoto Andi 
Published: March 2022

The Rabin-Karp algorithm is used to detect similarity using hashing techniques, from related studies modifications have been made in the hashing process but in previous studies have not been conducted research for the best k value in the K-Gram process. At the stage of stemming the Nazief & Adriani algorithm is used to transform the words into basic words. The researcher uses several variations of K-Gram values to determine the best K-Gram values. The analysis was performed using Ukara Enhanced public data obtained from the Kaggle with a total of 12215 data. The student essay answers data totaled to 258 data in the group A and 305 in the group B, every student essay answers data in each group will be compared with the answers of other fellow group member. Research results are the value of k = 3 has the best performance which has the highest some interpretations of 1-14% (Little degree of similarity) and 15-50% (Medium level of similarity) compared to values of k = 5, 7, and 9 which have the highest number of interpretation results 0%-0.99% (Document is different). However, if the students essay answers compared have 100% (Exactly the same) interpretations, the k value on K-Gram does not affect the results.
Transfer Learning of Pre-trained Transformers for Covid-19 Hoax Detection in Indonesian Language
Authors: Suadaa Lya Hulliyyatus , Santoso Ibnu , Panjaitan Amanda Tabitha Bulan 
Published: March 2022

Nowadays, internet has become the most popular source of news. However, the validity of the online news articles is difficult to assess, whether it is a fact or a hoax. Hoaxes related to Covid-19 brought a problematic effect to human life. An accurate hoax detection system is important to filter abundant information on the internet. In this research, a Covid-19 hoax detection system was proposed by transfer learning of pre-trained transformer models. Fine-tuned original pre-trained BERT, multilingual pre-trained mBERT, and monolingual pre-trained IndoBERT were used to solve the classification task in the hoax detection system. Based on the experimental results, fine-tuned IndoBERT models trained on monolingual Indonesian corpus outperform fine-tuned original and multilingual BERT with uncased versions. However, the fine-tuned mBERT cased model trained on a larger corpus achieved the best performance.
EFL STUDENTS’ MOTIVATION IN ENGLISH SPEAKING CLASS AT THE TWELFTH GRADE OF SENIOR HIGH SCHOOL DURING COVID-19 PANDEMIC
Authors: Damayanti Rosma Nofi , Hakim Putri Kamalia , Abas Totoh Tauhidin 
Published: March 2022

Learning speaking skill is one of the important components for mastering English skills of EFL students, including Indonesian students. However, this learning process is not easy to do, because English in Indonesia as a foreign language and also difficult to do in the current COVID-19 pandemic situation. This has an effect on students' motivation in learning to speak English. Motivation has an important role in the success of learning speaking foreign languages including English. The purpose of this study is to analyze the motivation of EFL students in English speaking class during COVID-19 pandemic based on Gardner's theory and to analyze the difficulties in speaking English that will affect students' motivation. This study was conducted at a senior high school in Bekasi, Indonesia. The participants consisted of eight students in twelfth grade. The research design in this study used a case study. Data was collected through observation, focus group discussion (FGD), and documentation. Observation and FGD was carried out via Zoom meeting. The data analysis used is thematic analysis. The result of this study is the students have instrumental and integrative motivation. However, students are motivated more instrumentally than integratively. The most students are instrumentally motivated for future interests such as as get a better job, continuing education, and to achieve success in the future. Then, many students experience difficulties in pronunciation and grammar which can influence their motivation in speaking English. This study has limitations, because the participants only consisted of eight students from twelfth grade. Keywords: EFL Students, Motivation, Speaking