bluuebunny/crossref_metadata_2025_split huggingface dataset:
Philosophy in relation to other disciplines exploring human nature
Authors: Haldane John 
Published: January 2022

AbstractThis paper explores philosophy in its relation to other disciplines and practices that also seek to understand the distinctive nature of human persons. It begins with a consideration of the nature of philosophy, arguing for a pluralistic conception reflecting different ends, and relating these to art, politics, religion, and science. It illustrates this via connections between the thought and work of Andy Warhol and Arthur Danto, Wagner and Nietzsche, and Roger Scruton and James MacMillan. It then shifts to a fifth methodological conception of philosophy as the discipline of disciplines, specifically in clarifying concepts and presuppositions, and relates this to marking the boundaries of personhood. Finally, it explores a particular example of philosophy in relation to another practice, art, this time giving priority to art itself.
HnRNP K mislocalisation in neurons of the dentate nucleus is a novel neuropathological feature of neurodegenerative disease and ageing
Authors: Sidhu Rahul , Gatt Ariana , Fratta Pietro , Lashley Tammaryn , Bampton Alexander 
Published: January 2022

AbstractNuclear depletion and cytoplasmic mislocalisation of the RNA‐binding protein heterogeneous ribonucleoprotein K (hnRNP K) within pyramidal neurons of the frontal cortex have been shown to be a common neuropathological feature in frontotemporal lobar degeneration (FTLD) and elderly control brain. Here, we describe a second neuronal subtype vulnerable to mislocalisation within the dentate nucleus of the cerebellum. In contrast to neurons within the cerebellar cortex that typically exhibited normal, nuclear staining, many neurons of the dentate nucleus exhibited striking mislocalisation of hnRNP K to the cytoplasm within neurodegenerative disease brain. Mislocalisation frequency in this region was found to be significantly higher in both FTLD‐TDP A and Alzheimer's disease (AD) brain than in age‐matched controls. However, within control (but not disease) subjects, mislocalisation frequency was significantly associated with age‐at‐death with more elderly controls typically exhibiting greater levels of the pathology. This study provides further evidence for hnRNP K mislocalisation being a more anatomically diverse pathology than previously thought and suggests that potential dysfunction of the protein may be more broadly relevant to the fields of neurodegeneration and ageing.
Experimental evidence of quint points and non-quantum chirality in a minimalist autonomous electronic oscillator
Authors: Volos Christos K. , Gallas Jason A. C. 
Published: January 2022

AbstractRecent intensive simulations have uncovered remarkable phenomena in stability diagrams of classical oscillators, for instance, quint points, parameter rings, and chiral structures of non-quantum origin. So far, their experimental observation has remained elusive. Here, using a simple electronic circuit, we report the experimental detection of five phases of oscillation spread around a quint point, an exceptional point where five oscillatory modes meet. This finding corroborates predictions of non-quantum chirality in the control parameter space of nonlinear oscillators governed by rate equations.
Bad Speech, Good Evidence: Content Moderation in the Context of Open-Source Investigations
Authors: Hubley Hillary 
Published: January 2022

Abstract
This article explores how content moderation on social media platforms impacts the work of open-source investigators through its routine removal of content having evidentiary value. These practices have rendered social media platforms susceptible to public criticism and scrutiny. However, these criticisms have largely been levied by a community who cares about content removal’s impact on free expression online. This swath of concerns does not comport with those of international criminal investigators who have increasingly turned to platforms for evidence gathering. Rather than confronting the issue, investigators have absorbed the costs by downplaying the impact of content removal on their work and by seeking to preserve the content on their own. I examine the disconnect between these two groups in their respective approaches to the problem of content removal and argue that both communities can stand to benefit from joining forces and taking notice of the convergence of their respective concerns.
Single-Incision Laparoscopic Complete Mesocolic Excision With Central Vascular Ligation for Descending Colon Cancer
Authors: Tei Mitsuyoshi , Suzuki Yozo , Ohtsuka Masahisa , Mizushima Tsunekazu , Akamatsu Hiroki 
Published: January 2022

Background Single-incision laparoscopic complete mesocolic excision with central vascular ligation for descending colon cancer is technically challenging. Standardization of the surgical procedures is therefore needed. Methods In a Trendelenburg position with left side elevated, the sigmoid mesocolon is mobilized using a medial-to-lateral approach, and the left colic artery and inferior mesenteric vein (IMV) are divided after radical lymphadenectomy along the inferior mesenteric artery, preserving the superior rectal artery. The descending mesocolon is mobilized from the retroperitoneal planes up to the dorsal surface of the pancreas using medial and lateral approaches. Next, changing the surgical position to a reverse Trendelenburg position with left side elevated, the omental bursa is opened, and the transverse mesocolon is separated from the inferior border of the pancreas. The splenocolic ligament and lateral attachment are then divided, matching the previous medial dissection of the retroperitoneum, and the splenic flexure is fully mobilized. The IMV is divided again at the inferior border of the pancreas. The left branch of the middle colic artery is also divided. Results Forty-seven consecutive patients with DCC underwent single-incision laparoscopic CME with CVL. One patient required an additional port. Median operative time, blood loss, and number of harvested lymph nodes were 240 min (interquartile range [IQR], 195-257 min), 5 mL (IQR, 5-52 mL), and 21 (IQR, 13-29), respectively. Morbidity rate was 5.9%. Median duration of hospitalization was 9 days (IQR, 7-11 days). Conclusions Single-incision laparoscopic CME with CVL is safe and feasible for DCC.
Trends in Health Care Access Disparities Among Asian and Pacific Islander Health Fair Participants in Los Angeles, 2011-2019
Authors: Dhanjani Suraj Avinash , Yang Hong-Ho , Goyal Shuchi , Zhang Kevin , Gee Gilbert , Cowgill Burton 
Published: January 2022

Objectives: Given several efforts to improve health care access in California and nationally, we studied whether linguistic and socioeconomic disparities in health care access changed from 2011 to 2019 among Asian and Pacific Islander American (APIA) people in Los Angeles, California. Methods: We analyzed survey responses from APIA health fair participants (n = 5032) in the Greater Los Angeles area from May 15, 2011, through October 20, 2019. To assess the effect of socioeconomic factors on and shifts in health care access (ie, health insurance status/regular doctor), we used a logistic regression model. Covariates included English proficiency, year, age, sex, ethnicity, income, employment, and education. We also ran an interaction analysis between English proficiency and year. Results: Health insurance access increased and doctor access remained stable throughout the study period; however, disparities in health insurance status widened by a factor of 1.08 per year between participants with high English proficiency (HEP) and participants with low English proficiency (LEP) ( P = .01). People with HEP were 2.02 times more likely to have a regular doctor than people with LEP ( P < .001), and this disparity persisted from 2011 to 2019 ( P = .58). Participants who were young ( P < .001) and male ( P = .005) were significantly less likely to have health insurance and a regular doctor ( P < .001) than participants who were older and female. Chinese participants were significantly more likely than Thai ( P = .002) and Korean ( P < .001) participants to be insured but not more likely to have a regular doctor, when controlling for health insurance. Conclusions: Policy changes targeting language and cultural barriers to care for APIA people with LEP may address the disparities observed.
Evaluation of a nasopharyngeal stent in patients with obstructive sleep-related breathing disorders
Authors: Dellweg Alexander , Kampmann Martin , Tschopp Kurt 
Published: January 2022

Objective This study was performed to evaluate the therapeutic effect and diagnostic value of a novel nasopharyngeal stent (Naśtent; Corinium Medical Equipment Ltd., Cirencester, UK). The Naśtent is designed to stent palatal collapse in patients with sleep-related breathing disorders. Methods The study was conducted from 2018 to 2019. Patients who did not qualify for continuous positive airway pressure therapy underwent split-night examination with an inserted Naśtent for the first half of the night. The next morning, drug-induced sleep endoscopy (DISE) was performed. Results Of the 122 enrolled patients, 21 were excluded because of Naśtent intolerance (n = 14) or technically invalid examinations (n = 7). Among the remaining 101 patients, in correlation with DISE, the apnea–hypopnea index was significantly reduced in patients with palatal obstructions, mainly in those with anteroposterior collapse patterns. The Naśtent did not influence retrolingual or multilevel obstructions. Using a 40% reduction of the apnea–hypopnea index by the Naśtent as a cut-off value, 85.7% of soft palate obstructions were detected compared with DISE. Conclusions The Naśtent is a viable tool to reduce palatal obstructions, although it is not readily tolerated. It may also be helpful for diagnosis of sleep-related breathing disorders when DISE is unavailable.
Sustainable supplier selection and order allocation for multinational enterprises considering supply disruption in COVID-19 era
Authors: Shao Yifan , Barnes David , Wu Chong 
Published: January 2022

The unprecedented outbreak of COVID-19 has left many multinational enterprises facing extremely severe supply disruptions. Besides considering triple-bottom-line requirements, managers now also have to consider supply disruption due to the pandemic more seriously. However, existing research does not take these two key objectives into account simultaneously. To bridge this research gap, based on the characteristics of COVID-19 and similar global emergency events, this article proposes a model that aims to solve the problem of sustainable supplier selection and order allocation considering supply disruption in the COVID-19 era. It does so by using a multi-stage multi-objective optimization model applied to the different stages of development and spread of the pandemic. Then, a novel nRa-NSGA-II algorithm is proposed to solve the high-dimensional multi-objective optimization model. The applicability and effectiveness of the proposed model is illustrated in a well-known multinational producer of shortwave therapeutic instruments. JEL Classification: M11
Dynamic Impacts of Economic Policy Uncertainty on Australian Stock Market: An Intercontinental Evidence
Authors: Bairagi Ranajit Kumar 
Published: January 2022

This study empirically investigates the impacts of economic policy uncertainty (EPU) of five countries from four continents on the Australian stock market with monthly observations from January 1998 to January 2021. The dynamic linkage model reports that EPUs are negatively influenced by their own lagged effect along with bidirectional volatility spillover and the returns of stock markets unidirectionally spillover to the EPU of the corresponding economy. The study documents that shocks originated in the Australian stock market spillover negatively onto its own EPU and that of China and positively onto EPUs of Europe and Japan. The shocks originated in EPUs of Australia, Europe, China, and Japan significantly negatively impact the Australian stock market. The bidirectional volatilities of EPUs can offer insight for portfolio investors in searching the possible hedging opportunities in Australia. The reported drivers of Australian EPU can be incorporated in formulating and implementing the EPU-sensitive Australian trade policies. JEL: G15, G17, G18
Differential Histone Posttranslational Modifications Induced by DNA Hypomethylating Agents
Authors: Malkaram Sridhar A , Shatnawi Aymen , Fan Jun , Carraway Hetty , Denvir James , Primerano Donald A , Abd Elmageed Zakaria Y , Fandy Tamer E 
Published: January 2022

Introduction The prototype DNA hypomethylating agents 5-azacytidine (5AC) and decitabine (DAC) are currently FDA-approved for treatment of blood and bone marrow disorders like myelodysplastic syndrome. 5AC and DAC are considered similar drugs and were shown to induce histone modifications that modulate gene expression. The aim of this study is to compare the effect of both drugs on histone acetylation and methylation at multiple histone amino acids residues. Methods Mass spectrometry was used to compare the effect of both drugs on 95 different histone posttranslational modifications (PTMs) in leukemia cells. ChIP-Seq analysis was used to compare the impact of both drugs on the genome-wide acetylation of the H3K9 mark using primary leukemia cells from six de-identified AML patients. Results Both DAC and 5AC induced histone PTMs in different histone isoforms like H1.4, H2A, H3, H3.1, and H4. Changes in both histone methylation and acetylation were observed with both drugs; however, there were distinct differences in the histone modifications induced by the two drugs. Since both drugs were shown to increase the activity of the HDAC SIRT6 previously, we tested the effect of 5AC on the acetylation of H3K9, the physiological substrate SIRT6, using ChIP-Seq analysis and compared it to the previously published DAC-induced changes. Significant H3K9 acetylation changes ( P< .05) were detected at 925 genes after 5AC treatment vs only 182 genes after DAC treatment. Nevertheless, the gene set modified by 5AC was different from that modified by DAC with only ten similar genes modulated by both drugs. Conclusion Despite similarity in chemical structure and DNA hypomethylating activity, 5AC and DAC induced widely different histone PTMs and considering them interchangeable should be carefully evaluated. The mechanism of these histone PTM changes is not clear and may involve modulation of the activity or the expression of the enzymes inducing histone PTMs.
Interactions between language and inhibitory control: Evidence from a combined language switching and Stroop paradigm
Authors: Yahya Mevla , Özkan Ceylan Arzu 
Published: January 2022

Aims and objectives: This study assessed bilinguals’ language control (LC) and inhibitory control (IC) performance (switch costs and Stroop effects) simultaneously in the same participants to investigate how these processes influence each other. Design: Seventy-four Turkish-English bilinguals were presented with Turkish (L1) or English (L2) color words printed either in congruent or incongruent ink color and instructed to name the ink color of these words in the presentation language. Stimuli’s language and congruency were either the same as in the previous trial or different. Data and analysis: Reaction times (RTs), switch costs (mean RTs on language repetition subtracted from switch trials), and the Stroop effects (mean RTs on congruent subtracted from incongruent trials) were analyzed using the linear mixed-effect model. Findings: The switch costs were larger on incongruent than congruent, and the Stroop effects were larger on language switch than repetition trials. This means that the LC performance decreased while resolving conflict, and the IC performance decreased during switching language, indicating that these two share a common IC mechanism. However, the switch costs and Stroop effects across L1 and L2 were symmetrical in all conditions, leaving the previous interpretation uncertain. Besides, the Stroop effects were larger when followed by congruent than incongruent trials during language repetition, whereas they were equal during switching. This means that the ability to adjust performance by previous experience was disrupted during language switching. Moreover, for the high-L2 proficiency group, this ability was diminished in language repetition trials too. These results indicate that rather than inhibition, other processes may primarily mediate bilinguals’ LC. Originality: This study provides evidence for how language and inhibitory control influence each other by combining language switching and Stroop paradigms. Furthermore, it investigates the sequential congruency effects (SCE). Significance/implications: This study shows that SCE investigation may provide significant theoretical implications.
Treatment of proximal scaphoid waist nonunions with vascularized bone graft from the distal radius or medial femoral condyle
Authors: Polat Oktay , Toy Serdar , Kibar Birkan 
Published: January 2022

Fractures of the proximal scaphoid waist are more prone to nonunion than distal scaphoid fractures. Thirty-nine patients (five females, 34 males; mean age 31 years) who had operation for proximal scaphoid waist nonunion between 2017 and 2020 were retrospectively analysed. Patients received a free vascularized medial femoral condyle graft (Group 1: 18 patients) or distal radial bone graft based on a 1,2 intercompartmental supraretinacular artery pedicle (Group 2: 21 patients). In Group 1, union was achieved in 17 of 18 cases, with mean time to union of 13 weeks and mean operation time was 221 minutes. In Group 2, union was achieved in 19 of 21 cases, with mean time to union of 15 weeks and mean operation time was 100 minutes. The radiological and functional results of both groups were similar. We recommend a distal radial bone graft based on the 1,2 intercompartmental supraretinacular artery pedicle for proximal scaphoid waist nonunions since the operation is shorter, technically more manageable and requires less microsurgical experience. Level of evidence: III
Comparison of a Focused Family Cancer History Questionnaire to Family History Documentation in the Electronic Medical Record
Authors: Clift Kristin , Macklin-Mantia Sarah , Barnhorst Margaret , Millares Lindsey , King Zacharay , Agarwal Anjali , Presutti Richard John 
Published: January 2022

Introduction: Family health history can be a valuable indicator of risk to develop certain cancers. Unfortunately, patient self-reported family history often contains inaccuracies, which might change recommendations for cancer screening. We endeavored to understand the difference between a patient’s self-reported family history and their electronic medical record (EMR) family history. One aim of this study was to determine if family history information contained in the EMR differs from patient-reported family history collected using a focused questionnaire. Methods: We created the Hereditary Cancer Questionnaire (HCQ) based on current guidelines and distributed to 314 patients in the Department of Family Medicine waiting room June 20 to August 1, 2018. The survey queried patients about specific cancers within their biological family to assess their risk of an inherited cancer syndrome. We used the questionnaire responses as a baseline when comparing family histories in the medical record. Results: Agreement between the EMR and the questionnaire data decreased as the patients’ risk for familial cancer increased. Meaning that the more significant a patient’s family cancer history, the less likely it was to be recorded accurately and consistently in the EMR. Patients with low-risk levels, or fewer instances of cancer in the family, had more consistencies between the EMR and the questionnaire. Conclusions: Given that physicians often make recommendations on incomplete information that is in the EMR, patients might not receive individualized preventive care based on a more complete family cancer history. This is especially true for individuals with more complicated and significant family history of cancer. An improved method of collecting family history, including increasing patient engagement, may help to decrease this disparity.
Correction of the Hindfoot Alignment after Supramalleolar Osteomy in Ankle Varus Deformity - A Three-Dimensional Analysis Using Weightbearing CT
Authors: Burssens Arne , Kvarda Peter , Steiner Caspar S. , Susdorf Roman , Peterhans Ursina , Krahenbuhl Nicola , Barg Alexej , Ruiz Roxa , Hintermann Beat 
Published: January 2022

Category: Ankle; Ankle Arthritis; Hindfoot Introduction/Purpose: While correction of varus alignment at the level of the ankle joint has been investigated extensively after supramalleolar osteotomy (SMOT), the effect on the hindfoot alignment remains unclear. This can be attributed to the limitations of former 2-dimensional radiographic measurements used to quantify the complex 3-dimensional subtalar joint alignment. Therefore, we aimed to determine both the ankle and subtalar joint alignment before and after SMOT using a weightbearing CT and autogenerated 3-dimensional measurements. Methods: Twenty-seven patients with a mean age of 53 years (SD=10.1; range=25-73) were retrospectively analyzed in a pre- post study design using weightbearing CT images. Inclusion criteria were correction of ankle varus deformity by either an opening wedge (N=19) or dome osteotomy (N=8). Exclusion criteria consisted of an additional inframalleolar bony correction, i.e. calcaneal osteotomy or subtalar arthrodesis. Corresponding three-dimensional bone models were reconstructed to compute the autogenerated measurements: tibial anterior surface (TAS) -, tibiotalar surface (TTS)-, talar tilt (TT) - and talocalcaneal (TC) angle. Results: The pre-operative (TAS=86.9°, SD=4.9; TTS=79.8°, SD=5.6; TT=8.8°, SD=4.3) radiographic parameters of the ankle joint alignment improved significantly compared to the post-operative parameters (TAS=92.4°, SD=4.9; TTS=87.1°, SD=6.3; TT=5.1°, SD=2.7; P<0.05). (Fig. 1A) Radiographic parameters to assess the subtalar joint alignment improved significantly from preoperatively (TCax =42.8°, SD=9.3; TCsag=42.3°,SD=10.9; TCcor =29.5°,SD=11.8) to post-operatively (TCax =37.8°, SD=8.8; TCsag=39.1°, SD=10.6; TCcor=24.6°,SD=9.1; P<0.05). (Fig. 1B) Conclusion: A supramalleolar osteotomy is able to correct both the ankle and subtalar joint alignment. However, correction at the level of the subtalar joint accounted for only 3 to 4 degrees, which was less than found for the ankle joint alignment. For cases where a higher correction at the subtalar joint is necessary, we thus suggest adding a calcaneal osteotomy or subtalar arthrodesis to the SMOT.