bluuebunny/crossref_metadata_2025_split huggingface dataset:
Full-color generation enabled by refractory plasmonic crystals
Authors: Chiao Zong-Yi , Chen Yu-Chia , Chen Jia-Wern , Chu Yu-Cheng , Yang Jing-Wei , Peng Tzu-Yu , Syong Wei-Ren , Lee Ho Wai Howard , Chu Shi-Wei , Lu Yu-Jung 
Published: May 2022

Abstract
Plasmonic structural color, in which vivid colors are generated via resonant nanostructures made of common plasmonic materials, such as noble metals have fueled worldwide interest in backlight-free displays. However, plasmonic colors that were withstanding ultrahigh temperatures without damage remain an unmet challenge due to the low melting point of noble metals. Here, we report the refractory hafnium nitride (HfN) plasmonic crystals that can generate full-visible color with a high image resolution of ∼63,500 dpi while withstanding a high temperature (900 °C). Plasmonic colors that reflect visible light could be attributed to the unique features in plasmonic HfN, a high bulk plasmon frequency of 3.1 eV, whichcould support localized surface plasmon resonance (LSPR) in the visible range. By tuning the wavelength of the LSPR, the reflective optical response can be controlled to generate the colors from blue to red across a wide gamut. The novel refractory plasmonic colors pave the way for emerging applications ranging from reflective displays to solar energy harvesting systems.
One-equation turbulence models applied to practical scramjet inlet
Authors: Pasha Amjad A. , Juhany Khalid A. , Pillai Subramania N. 
Published: May 2022

Abstract
Reynolds-averaged Navier–Stokes equations are used to simulate a practical scramjet inlet geometry using the shock-unsteadiness modified Spalart–Allmaras (SA) turbulence model. The geometry consists of fore-body ramps, expansion corners, and inlet ducts. The focus is to study the impingement of the cowl shock on the opposite wall boundary-layer. The resulting separation bubble can lead to blockage and inlet unstarts. The shock-unsteadiness correction is employed and is found to improve the computational fluid dynamics (CFD) prediction of flow separation in shock/boundary-layer interactions. The shock-unsteadiness parameter is calibrated against available experimental data of canonical flows, and the predicted flow-field is analyzed in detail. A large separation bubble size normalized to the upstream boundary-layer thickness of 4.6 is observed in the interaction region. Across the reattachment region in the interaction region, a peak value of wall pressure is observed. The inlet performance parameters are also calculated. The total pressure losses of 62% are observed across different shock waves, with an additional loss of 15% due to viscous boundary-layer effects.
Lernen unter Vorzeichen der Ambiguität: Biblische Perspektiven
Authors: Nicklas Tobias 
Published: May 2022

Zusammenfassung
Der Beitrag geht davon aus, dass die grundlegende Ambiguität, d. h. die Vielstimmigkeit, Widersprüchlichkeit und Mehrdeutigkeit der Bibel von entscheidender Bedeutung für die Funktion des Texts ist, Lernprozesse anzustoßen, Weltbilder herauszufordern und Konstruktionen von Identität zu begleiten. Er setzt auf zwei Ebenen an, einerseits der Ambiguität wichtiger Charaktere der Bibel, hier des Nikodemus, einer Figur des Johannesevangeliums, aber auch des „erzählten Gottes“ im Markusevangelium, andererseits der Ambiguität der Apokalypse des Johannes in Bezug auf die alles entscheidende Frage: Wer kommt in die Heilige Stadt, das himmlische Jerusalem? Das Zueinander der verschiedenen, Leser*innen verstrickenden Perspektiven im vielstimmigen Text wirft Fragen auf, die letztlich unbeantwortbar bleiben, gerade dadurch aber zur lebenslangen Aufgabe der Leser*innen werden.
Developmental Differences in Neuromagnetic Cortical Activation and Phase Synchrony Elicited by Scenes with Faces during Movie Watching
Authors: Kozhemiako Nataliia , Nunes Adonay S. , Moiseev Alexander , Márquez-García Amparo V. , Cheung Teresa P.L. , Ribary Urs , Doesburg Sam M. 
Published: May 2022

AbstractThe neural underpinnings of humans’ ability to process faces and how it changes over typical development have been extensively studied using paradigms where face stimuli are oversimplified, isolated, and decontextualized. The prevalence of this approach, however, has resulted in limited knowledge of face processing in ecologically valid situations, in which faces are accompanied by contextual information at multiple time scales. In the present study, we use a naturalistic movie paradigm to investigate how neuromagnetic activation and phase synchronization elicited by faces from movie scenes in humans differ between children and adults. We used MEG data from 22 adults (6 females, 3 left handed; mean age, 27.7 ± 5.28 years) and 20 children (7 females, 1 left handed; mean age, 9.5 ± 1.52 years) collected during movie viewing. We investigated neuromagnetic time-locked activation and phase synchronization elicited by movie scenes containing faces in contrast to other movie scenes. Statistical differences between groups were tested using a multivariate data-driven approach. Our results revealed lower face-elicited activation and theta/alpha phase synchrony between 120 and 330 ms in children compared with adults. Reduced connectivity in children was observed between the primary visual areas as well as their connections with higher-order frontal and parietal cortical areas. This is the first study to map neuromagnetic developmental changes in face processing in a time-locked manner using a naturalistic movie paradigm. It supports and extends the existing evidence of core face-processing network maturation accompanied by the development of an extended system of higher-order cortical areas engaged in face processing.
Identification of predictive criteria for pathogenic variants of primary bilateral macronodular adrenal hyperplasia (PBMAH) gene ARMC5 in 352 unselected patients
Authors: Bouys Lucas , Vaczlavik Anna , Jouinot Anne , Vaduva Patricia , Espiard Stéphanie , Assié Guillaume , Libé Rossella , Perlemoine Karine , Ragazzon Bruno , Guignat Laurence , Groussin Lionel , Bricaire Léopoldine , Cavalcante Isadora Pontes , Bonnet-Serrano Fidéline , Lefebvre Hervé , Raffin-Sanson Marie-Laure , Chevalier Nicolas , Touraine Philippe , Jublanc Christel , Vatier Camille , Raverot Gérald , Haissaguerre Magalie , Maione Luigi , Kroiss Matthias , Fassnacht Martin , Christin-Maitre Sophie , Pasmant Eric , Borson-Chazot Françoise , Tabarin Antoine , Vantyghem Marie-Christine , Reincke Martin , Kamenicky Peter , North Marie-Odile , Bertherat Jérôme 
Published: May 2022

Abstract

Objective
Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a heterogeneous disease characterized by adrenal macronodules and variable levels of cortisol excess, with not clearly established clinical diagnostic criteria. It can be caused by ARMC5 germline pathogenic variants. In this study, we aimed to identify predictive criteria for ARMC5 variants.

Methods
We included 352 consecutive index patients from 12 European centers, sequenced for germline ARMC5 alteration. Clinical, biological and imaging data were collected retrospectively.

Results
52 patients (14.8%) carried ARMC5 germline pathogenic variants and showed a more distinct phenotype than non-mutated patients for cortisol excess (24-h urinary free cortisol 2.32 vs 1.11-fold ULN, respectively, P  &lt; 0.001) and adrenal morphology (maximal adrenal diameter 104 vs 83 mm, respectively, P  &lt; 0.001) and were more often surgically or medically treated (67.9 vs 36.8%, respectively, P  &lt; 0.001). ARMC5-mutated patients showed a constant, bilateral adrenal involvement and at least a possible autonomous cortisol secretion (defined by a plasma cortisol after 1 mg dexamethasone suppression above 50 nmol/L), while these criteria were not systematic in WT patients (78.3%). The association of these two criteria holds a 100% sensitivity and a 100% negative predictive value for ARMC5 pathogenic variant.

Conclusion
We report the largest series of index patients investigated for ARMC5 and confirm that ARMC5 pathogenic variants are associated with a more severe phenotype in most cases. To minimize negative ARMC5 screening, genotyping should be limited to clear bilateral adrenal involvement and autonomous cortisol secretion, with an optimum sensitivity for routine clinical practice. These findings will also help to better define PBMAH diagnostic criteria.
Fertility preservation for transgender individuals
Authors: Barrett James 
Published: May 2022

Lay summary
Transgender people are just as able to be good parents as anyone else. The treatment involved in addressing their gender dysphoria usually removes their natural fertility and if they want to preserve their fertility, they will need gamete storage. The technology needed to provide gamete storage for transfolk is not any different from anyone else but the clinic setup, human interactions and the approach used need to be sensitive and require everyone in the clinic to understand the issues and behave accordingly if high-quality service is to be provided.
The future of diagnostic laparoscopy – Cons
Authors: Simko Sarah , Wright Kelly N 
Published: May 2022

Endometriosis has a large impact on the lives of patients, affecting nearly 90% of women with chronic pelvic pain and infertility. Unfortunately, diagnosis for this condition is often delayed by an average of 7 years, with adolescent patients experiencing disproportionate delays. This is in part due to the use of an invasive procedure for primary diagnosis and limited access to subspecialty care. While laparoscopy serves an important purpose in the diagnosis and management of endometriosis, it has been found to be less cost-effective than empiric medical therapy and puts an emphasis on the lesion as opposed to the patient and the disease process as a whole. As studies emerge, we gain a deeper understanding of the complex nature of this disease. Laparoscopy has been shown to have variable results, with high recurrence rates and varying improvement in symptoms over time. Additionally, studies have shown a poor correlation between patients’ pain and the stage and location of lesions, with laparoscopy showing greater benefit for later-stage disease and deep infiltrating endometriosis. This article seeks to evaluate the current standards for the management of endometriosis, discuss the place for diagnostic laparoscopy, and review future directions and alternatives.

Lay summary
Endometriosis is an inflammatory disorder that occurs when uterine tissue is found outside the uterus. This condition affects women of reproductive age and can have serious impacts on their lives, causing pain and difficulty getting pregnant. The primary method of diagnosis is surgical, which has associated risks and can delay care to patients. As further studies emerge, our understanding of this condition improves, and it is important to evaluate current practices. This article focuses on the pros and cons of using surgical methods to diagnose endometriosis and alternative options that may be safer and provide more timely care to patients.
Simultaneous determination of eight antiepileptic drugs and two metabolites in human plasma by liquid chromatography/tandem mass spectrometry
Authors: Yu Hengyi , Ren Xiuhua , Liu Lu , Xiang Dong , Li Xiping , Li Juan , Liu Dong , Gong Xuepeng 
Published: May 2022

AbstractEpilepsy is one of the most prevalent neurological conditions and antiepileptic drugs are the mainstay of epilepsy treatment. High variation in pharmacokinetic profiles of several antiepileptic drugs highlights the importance of therapeutic drug monitoring to estimate pharmacokinetic properties and consequently individualize drug posology. In this work, a simple, rapid and robust liquid chromatography-tandem mass spectrometry method was developed for simultaneous quantification of carbamazepine and its metabolite carbamazepine-10,11-epoxide, gabapentin, levetiracetam, lamotrigine, oxcarbazepine and its metabolite mono-hydroxy-derivative metabolite, phenytoin, topiramate, and valproic acid in human plasma for therapeutic drug monitoring. d6-Levetiracetam, d4-gabapentin and d6-valproic acid were used as internal standards. After addition of internal standards along with two-step protein precipitation and dilution sample preparation, plasma samples were analyzed on a C18 column using a gradient elution in 5 min without interference. The calibration curves were linear over a 100-fold concentration range, with determination coefficients (r2) greater than 0.99 for all analytes. The limit of quantification was 0.5 μg mL−1 (0.1 μg mL−1 for oxcarbazepine, 2 μg mL−1 for levetiracetam, and 10 μg mL−1 for valproic acid) with precision and accuracy ranging from 3% to 9% and from 94% to 112%, respectively. Intra- and inter-day precision and accuracy values were within 15% at low, medium and high quality control levels. No significant matrix effect was observed in the normal, hemolyzed, lipemic, and hyperbilirubin blood samples. This method was successfully used in the identification and quantitation of antiepileptic drugs in patients undergoing mono- or polytherapy for epilepsy.
Problematyka przedawnienia roszczeń w zakresie umów kredytów frankowych. Część 1
Authors: Makowski Bartłomiej 
Published: May 2022

Początek XXI wieku to czas masowego udzielania przez banki kredytów denominowanych lub indeksowanych do franka szwajcarskiego. Kredytobiorcy, zapewniani o bezpieczeństwie i korzyściach, jakie niosą z sobą „kredyty frankowe”, podpisywali umowy zawierające liczne wady prawne, w tym niedozwolone postanowienia umowne (klauzule abuzywne). Aktualnie problemy takich umów kredytowych, jak abuzywność klauzul przeliczeniowych, niedopełnianie przez banki obowiązków informacyjnych wobec klienta przy zawieraniu umów oraz inne naruszenia przepisów prawa bankowego i cywilnego, mocno zajmują sądy krajów członkowskich UE, w tym sądy polskie, oraz TSUE. Kwestią dyskusyjną jest jednak przede wszystkim fakt uznawania tego rodzaju umów za nieważne w całości oraz związana z tym konieczność dokonania rozliczenia stron z tytułu coraz częstszego orzekania przez sądy nieważności tego rodzaju umów.
Rozważania zawarte w niniejszym artykule skupiają się na niezwykle istotnej na tle wskazanych sporów o nieważność umów kredytowych problematyce przedawnienia roszczeń kredytobiorców, którzy pozywając banki, żądają zwrotu uiszczonych przez nich na rzecz banków nienależnych ich zdaniem świadczeń od samego momentu zawarcia umowy. Wnikliwej analizie poddane zostało orzecznictwo sądów polskich oraz TSUE, którego wyroki wskazują, że bieg terminu przedawnienia może rozpocząć się dopiero z chwilą nabycia przez kredytobiorcę świadomości, iż zawarta przez niego umowa jest wadliwa, dzięki czemu możliwe staje się skuteczne wytoczenie powództwa.
Antithrombotic Therapy and the Nearest Forecast of Pulmonary Embolism in Rutine Clinical Practice (Data of the Regional Vascular Center of the Ryazan Region)
Authors: Nikulina N. N. , Terekhovskaya Yu. V. , Yakushin S. S. 
Published: May 2022

Aim. To perform the analysis of antithrombotic therapy and immediate prognosis in patients with pulmonary embolism (PE) in routine clinical practice.Materials and methods. During 13 months of follow-up (2018-2019) within the framework of the Russian SIRENA registry, the study included patients (n=103) with verified PE who were hospitalized at the regional vascular center. Main results. Thrombolytic therapy was performed in 63 patients (61.2% of the sample), of which 48 (76.2%) had no indications. In these cases, the most common reason for performance was the results of the PESI score (n=17) and/or a significant amount of damage to the pulmonary artery (n=10) and/or severe shortness of breath (n=3) and/or the presence of a thrombus in the right parts of the heart or deep veins of the lower extremities (n=2), in addition, in a number of medical records, the cause is indicated as “for health reasons” (n=6) or there were no data (n=10). Patients who underwent thrombolysis had a larger volume of pulmonary lesions, more pronounced signs of respiratory failure and overload of the right heart, as well as a shorter duration of clinical manifestations. Anticoagulant therapy was used in 94.2% of cases, of which 90.3% of patients used parenteral forms at the start, then direct oral anticoagulants were mainly used, the frequency of warfarin prescription was only 5.8% of cases. Bleeding was registered in 19.4% of patients (significant – in 11.7%). PE recurrence after diagnosis and initiation of therapy was observed in 4 cases (3.9%). Hospital mortality was 9.7%. Predictors of poor prognosis were hospitalization with a different diagnosis (risk ratio [RR] 16.2; p=0.001), advanced age (RR 10.1; p=0.028), unstable hemodynamics (RR 7.6; p=0.002), chronic kidney disease C3- 5 (RR 5.6; p=0.03), history of stroke (RR 5.3; p=0.016) and chronic heart failure (RR 3.9; p=0.035).Conclusion. In modern clinical practice, the indications for thrombolysis often differ from those recommended, which leads to an increase in the number of bleeding and leveling of the positive effect on the prognosis. Factors such as advanced age, chronic heart failure and atrial fibrillation, stroke, chronic kidney disease, hemodynamic instability, hospitalizations with a different primary diagnosis, and the need for oxygen therapy increase the risk of early mortality.
The central role of self-esteem in the quality of life of patients with mental disorders.
Authors: Barbalat Guillaume , Plasse Julien , Gauthier Emmanuel , Verdoux Hélène , Quiles Clélia , Dubreucq Julien , Legros-Lafarge Emilie , Jaafari Nematollah , Massoubre Catherine , Guillard-Bouhet Nathalie , Haesebaert Frédéric , Franck Nicolas 
Published: May 2022

Abstract
In psychiatry, recent years have seen a change of focus from a clinician- to a patient- centered perspective that emphasizes quality of life as a treatment target. As a complex construct, quality of life is composed of multiple dimensions that interact with one-another (e.g. physical and psychological well-being, relationships, autonomy, self-esteem). Here, we used data from the REHABase cohort, which includes N=2180 patients from 15 psychosocial rehabilitation centers in France, to explore networks of quality-of-life dimensions among six psychiatric disorders: schizophrenia, neurodevelopmental, bipolar, depressive, anxiety, and personality disorders. Stronger connections (edges) involved the Self-Esteem dimension, such as Self-Esteem--Physical Well-Being, Self-Esteem--Autonomy, Self-Esteem--Psychological Well-Being, and Self-Esteem--Resilience. Self-esteem was also consistently retrieved as the most central node (the dimension with the most connections within each network). Between-group tests did not reveal any differences regarding network structure, overall connectivity, edge-weights, and nodes’ centrality. Despite presenting with different symptom profiles, various psychiatric disorders may demonstrate similar inter-relationships among quality-of-life dimensions. In particular, self-esteem may have a crucial inter-connecting role in patients’ quality of life. Our findings could support treatment programmes that specifically target self-esteem to improve patients’ quality of life in a cost-effective way.
Genetic origin of donkeys in Brazil
Authors: Alves Jackeline Santos , Oliveira Chiara Albano de Araujo , Escodro Pierre Barnabé , Pinto Luis Fernando Batista , Costa Raphael Bermal , de Camargo Gregório Miguel Ferreira 
Published: May 2022

Abstract
The genetic groups of native donkeys in Brazil are characterized by adaptation to the local environment. However, the donkey population in the country is declining, mainly because of agricultural mechanization and transportation that has led to the abandonment and the consequent indiscriminate slaughter of these animals. There are three local genetic groups of distinct geographic and temporal formation. However, analyses of their origin, phylogenetic relationship, and population structure are scarce. Within this context, molecular markers such as the mitochondrial control region (D-loop) are useful for these analyses. This study aimed to evaluate the variation and origin of maternal lineages of groups of naturalized donkeys in Brazil (Brazilian, Nordestino and Pêga). We detected five mitochondrial haplotypes with 18 polymorphic sites, two of them exclusively found in the Nordestino donkey. This group is more distant from the other groups. Phylogenetic analysis indicates maternal contributions of two clades (Nubian and Somali) to the formation of the genetic groups of donkeys, a fact that explains the high diversity, structure and distances of the groups. It was firstly reported here. This analysis contributes production and conservation of native donkey breeds. It also gives clues about the formation of the Iberian breeds from which Brazilian donkeys originated.
Fish Parasites as Biological Indicators of Metals Pollution in the Aquatic Environments
Authors: Mostafa Osama , Hanfi Tasneem , Abd-eltwab Doaa , Al-Shehri Mohammed , Moustafa Mahmoud , Al-Emam Ahmed , Alhamdi Heba , Nigm Ahmed 
Published: May 2022

Abstract
In this review the papers concerned with fish parasites that utilized as biological indicators of metals pollution in the aquatic environments and published between 2010 and 2021 were retrieved according to certain inclusion and exclusion criteria. The fish-parasite models in the retrieved publications differed widely, and only five helminthic species were considered as bioindicators with their recurrence evaluated as follows: acanthocephalan and nematodes > cestodes > trematodes > crustacea. The majority of the investigations were focused on freshwater fish. The frequency of examinations into metals bioaccumulation within the host tissues was evaluated as follows: liver and muscles > gut > kidney > gills and gonads > brain and adipose tissue. Cd was the most commonly studied metal, followed by Pb, and the remaining elements being classified as Cu > Zn > Mn > Cr& Fe > Ni > As > Al & Co > Hg, Se, Sn, Ti& V > Mg& Ba. The elements Mo, Pt, Sb, Th, U, and Sr were all tested once. In conclusion, fish parasites can be used as a biological indicator of metal pollution while also reducing metal bioaccumulation in fish tissues, as they can accumulate heavy metals in their tissues at a higher rate than fish tissues. Therefore, the parasites might act as metal biosinks or sentinels in aquatic habitats. In addition, reduced chemical absorption in animals employed in ecotoxicological studies due to parasitic infections, may confuse researchers into believing that pollution levels are minimal.
Assessment of Mechanical and Tribological Properties of Mono and Hybrid Composite by Statistical Technique
Authors: MUKUNDAIAH RAVIKUMAR , Naik Rudra , Reddappa H N 
Published: May 2022

Abstract
In this study, experiments have been carried out by performing tensile strength, hardness and sliding wear tests of Aluminium (Al) 7075 alloy, mono-composite (Al7075 + 10% Al2O3) and hybrid composite (Al7075 + 10% Al2O3 + 5% SiC) as per ASTM. The mono-composite and hybrid-composite are developed through stircasting method. It was found that an increase of hard ceramic particulates resulted in improved hardness, enhanced tensile strength. However, hybrid composites have better hardness, improved tensile strength as compared with Al 7075 alloy. Wear studies were performed using pin-on-disc wear test rig. The wear parameters are optimized using Taguchi technique. The results have revealed that the load is more significant on wear behavior of Al7075 alloys followed by speed & sliding distance. The addition of Al2O3 and SiC particulates to Al7075 improves the tribological behavior in mono composite and hybrid composite. Micrograph studies revealed damages due to adhesion and abrasion. The moropology of the wornout surface of mono composite exibhits the side flow with deep grooves. It reveals the indication of abrasive mechanism of mono composites. The hybrid MMCs (Al7075 + 10% Al2O3 + 5% SiC) show better wear resistance compared to the monolithic and mono composites.