bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cuproptosis is correlated with clinical status, tumor immune microenvironment and immunotherapy in colorectal cancer: a multi-omic analysis
Authors: Shao Yanfei , Fan Xiaodong , Yang Xiao , Li Shuchun , Huang Ling , Zhou Xueliang , Zhang Sen , Zheng Minhua , Sun Jing 
Published: September 2022

ABSTRACTCopper, like double-edged sword, either too little or too much can lead to cell death. Cuproptosis, a novel identified cell death form induced by copper, is characterized by aggregation of lipoylated mitochondrial enzymes and the destabilization of Fe–S cluster proteins. However, the function and potential clinical value of cuproptosis in colorectal cancer remains largely unknown. In this study, 16 cuproptosis-related molecules (CPRMs) were identified and analyzed by transcriptomics, genomics, and single-cell transcriptome profiling from multiple databases. We established two cuproptosis-related molecular phenotypes (CMP1 and 2) to distinguish CRC individuals, in which there were significantly differences in prognosis, biological function, somatic mutation frequency, immune cell infiltration in CRC individuals. A novel cuproptosis-related scoring system (CuproScore) was also constructed to predict the prognosis of CRC individuals, TME and the response to immunotherapy. Of notion, the value of CuproScore was also confirmed in our transcriptome cohort, demonstrating that CRC individuals in the high CuproScore group tended to have higher immune cell infiltrations and higher immune checkpoint expression. We also checked and analyzed the expression and clinical significance of 16 CPRMs in CRC cell lines and CRC tissues. This study indicated that cuproptosis and CPRMs played significant role in CRC progression and in modeling the TME. Inducing cuproptosis may be a useful tool for tumor therapy in the future.
Effect of Soret on MHD rotating fluid flow through a porous medium with heat and mass transfer
Authors: T. Lawanya , M. Vidhya , A. Govindarajan 
Published: September 2022

Purpose
The purpose of this paper to analyze the effect of Soret with heat and mass transfer on an unsteady two-dimensional Magnetohydrodynamics flow through a porous medium under the influence of the uniform transverse magnetic field in a rotating parallel plate is considered.

Design/methodology/approach
A mathematical model was developed using the slip conditions under unsteady state situations. Analytical expressions for the velocity, temperature and concentration profiles, wall shear stress, rates of heat and mass transfer and volumetric flow rate were obtained and computationally discussed with respect to the non-dimensional parameters. Further, the velocity reduces with increasing Hartmann number M and increases with Grashof number Gr and permeability parameter K.

Findings
It is observed that temperature reduces with an increase in Prandtl number Pr and ω. It is noted that the thermal radiation increases with increase in Soret number Sr, Schmidt number Sc, Prandtl number pr and ω.

Originality/value
Concentration decreases with an increase in radiation parameter R and chemical reaction parameter Kc.
Towards digital access during pandemic age: better learning service or adaptation struggling?
Authors: Huda Miftachul 
Published: September 2022

PurposeThe presence of digital learning space is widely seen as there is an active engagement between educators and learners. However, the challenge raised mainly amidst the pandemic age, which is potentially leading to the interference on the active engagement in education process. The necessary act to have a critical response from the student’s feedback towards the online learning services should be taken into consideration in ensuring the continuance of teacher education in enabling to grab the potential chance to advance the assessment of strategic approach in online learning. This paper aims to examine the digital access during the pandemic age through elaborating the extensive value of better learning service or adaptation for the online learning achievement amidst the pandemic age.Design/methodology/approachThis study is conducted with a qualitative approach through the particular method of data collection, namely, structured interview. This qualitative approach was selected to enable obtaining the richness of information and related data. The insightful feedback will be coming from 27 higher education learners.FindingsThe finding revealed that better design of achievement pathway on the digital access could be enhanced in supporting the online learning performance through the online services. The main point refers to look into detail about digital online infrastructure insufficiency for online access support and improvements on digital online infrastructure for accessibility of learning service. The main occupations are clearly pointed in the following phase. Those are empowering digital access for learning service support and enhancing digital-adaptation for online learning achievement.Originality/valueThis study is supposed to contribute in assisting the value contribution with an extensive point to continue the digital access during pandemic age through the adaptation empowerment of higher learner’s online learning services.
E-learning programs in executive education: effects of perceived quality and perceived value on self-regulation and motivation
Authors: Kumar Ranjan 
Published: September 2022

PurposeThe purpose of this study is to investigate the effects of perceived quality and perceived value on learner motivation and engagement in executive education e-learning programs.Design/methodology/approachThe structural model comprising four constructs – perceived quality (PQ), perceived value (PV), self-regulated learning (SRL) and intrinsic motivation (IM) – was empirically validated through path analysis. Mediation analysis and importance-performance map analysis (IPMA) was also conducted.FindingsThis study shows that PQ has a positive effect on PV; PV has a positive effect on SRL and on IM; and SRL has a positive effect on IM. Further, variance accounted for (VAF)-based mediation analysis established the partial mediating effect of SRL between PV and IM.Practical implicationsOne, perceived quality and perceived value play a pivotal role in driving learner engagement and motivation in e-learning-based executive education programs. Two, the “pathway” effect of self-regulated learning between perceived value and intrinsic motivation has a crucial bearing on the design-execution-outcome lifecycle of such programs. Three, low-moderate performance scores of PQ, PV, and SRL in IPMA analysis implies these inputs are inadequate, adversely impacting learner motivation and engagement.Originality/valueRecommendations from this pioneering study can be adopted by higher education (HE) ecosystem stakeholders to enhance perceived quality and value, learner motivation, engagement and learning outcomes in e-learning programs for executive education.
Does market performance mediates the nexus between production performance and financial performance in manufacturing companies?
Authors: Shanak Hosni Shareif Hussein , Abu-Alhaija Ahmad Saifalddin 
Published: September 2022

Purpose
Based on recent government reports, the manufacturing industry is considered one of the most important sectors in Palestine. In this sense, this empirical study aims to investigate the influence of production performance on financial and market performances, assess the influence of market performance on financial performance and test the mediating role of market performance on the relationship between production and financial performances.

Design/methodology/approach
A convenience sampling method was applied. Accordingly, a set of questionnaires was distributed to 384 managers at Palestinian manufacturing enterprises. Structural equation modelling (SEM) was applied to analyse the collected data.

Findings
The study findings unveiled that production performance directly positively has a positive and direct influence on the financial and market performances. Furthermore, the result revealed that financial performance is positively affected by market performance level, whereas market performance has a partial mediation role in the relationship between financial and production performances.

Research limitations/implications
The study designs are restricted to the manufacturing companies. Hence, the empirical results may not generalise to the other industries.

Practical implications
The findings of this study can draw responsible parties and firms’ top management attention in developing countries to the importance of market performance as a key pillar of firm performance.

Originality/value
To the best of authors’ knowledge, most of the prior contemporary studies have been restricted to examine the direct relationship and have not considered the mediating influence of market performance. Besides, this study emphasised the inter-relationships between the firms’ performance dimensions. This study contributes to manufacturing firms’ performance literature by providing further validation of the performance scales from a developing countries “Palestine” with unique business environment because it is under ongoing occupation.
Libraries respond to the COVID-19 pandemic: drawing a science map of published articles
Authors: Nadi-Ravandi Somayyeh , Batooli Zahra 
Published: September 2022

PurposeThe lockdown of libraries has led to changes in the delivery of services. Reviewing many studies in this regard appears to be of great importance. Thus, this study aims to analyze the articles related to libraries and COVID-19 using the co-occurrence analysis.Design/methodology/approachThe current study is applied in terms of purpose and scientometrics in terms of type, which has been conducted using a retrospective bibliometric analysis method and drawing a science map. The relevant keywords were searched in the Scopus and 225 articles were reviewed in terms of author, year of publication, journal, organization and subject. Then, the VOSviewer software was used to analyze and illustrate the keywords and draw the scientific map of the articles.FindingsThe results showed that 225 articles by 496 authors from 66 countries and 379 organizations were published in the subject area of libraries and COVID-19. These articles have received 620 citations. The co-occurrence analysis of words showed that these scientific productions are classified into four clusters: “The role of libraries and librarians”, “The use of media, social network and communication technologies in order provide library services”, “Online Library Services” and “Infodemic and misinformation in the COVID-19 Pandemic”.Originality/valueIt is the first time during the COVID-19 pandemic that a scientific map has been drawn up of studies that have examined the role of libraries in this pandemic. The results of the present study may help libraries to access what they need to consider in any crisis.
The potential health benefits and food applications of jamun (Syzygium cumini L.), an indigenous fruit of India
Authors: Ayenampudi Surendra Babu , Verma Riya , Adeyeye Samuel Ayofemi Olalekan 
Published: September 2022

Purpose
Jamun is an underutilised fruit crop of India whose utilization needs to be considerably increased. Despite its impressive nutritional profile and several health benefits, its cultivation is still very limited. Hence, this study aims to highlight the essential nutrients, health benefits and value-added products of jamun fruit and seed.

Design/methodology/approach
Major sources of bibliometric information such as Web of Science, Scopus, PubMed and Google Scholar were extensively searched with keywords such as nutritional composition of jamun, bioactive compounds, health benefits and jamun-based food products to obtain a database of 317 papers. Thirty four publications met the criteria for review.

Findings
Jamun fruit (Syzygium cumini L.) is known for its attractive colour, astringent taste, enormous nutrients and nutraceutical properties; nevertheless, this fruit is seasonal, perishable and underutilised. Furthermore, the fruit is used for the treatment of diabetes and also possess anti-cancer, anti-inflammatory, anti-obesity and cardio-protection properties. Investigations were done on the production of value-added food products such as read-to-serve beverages, jam, cookies and cake from jamun due to their several health benefits. The present review was an attempt to provide spotlights on the health benefits and food product applications of jamun fruit and its by-products.

Originality/value
This review systematically collates evidence from various published sources regarding the nutritional profile, development of food products from jamun and their health benefits. The compiled information will help researchers and professional become aware of the significance of jamun fruit and thereby enhances its processing and applications in food systems.
Service recovery efforts' influence on consumers' desire to reciprocate and forgiveness: the mediating role of perceived justice
Authors: Umar Rana Muhammad 
Published: September 2022

PurposeThis paper investigated the impact of firms' service recovery efforts on consumers' desire to reciprocate and forgiveness in the hospitality industry of Pakistan. Additionally, this study examined the mediating role of perceived justice between service recovery efforts and their outcomes.Design/methodology/approachUsing snowball sampling technique, an online survey was administered and 259 responses were collected from casual-dining restaurant customers. A partial least squares structural equation modeling (PLS-SEM) and multivariate analysis of covariance (MANCOVA) were used to examine the hypotheses.FindingsThe results indicate that perceived justice significantly mediates the effect of service recovery efforts on the consumers' desire to reciprocate and forgiveness. Moreover, high (vs. low) service recovery efforts lead to high consumer forgiveness.Practical implicationsThe study provides insights for managers into how optimal recovery efforts predict consumers' positive responses and minimize the effect of service failure in South Asian consumers.Originality/valueThis research is among the early endeavors to examine consumers' desire to reciprocate in service recovery context. Also, this is the first study to validate the impact of service recovery efforts on consumers' desire to reciprocate and consumer forgiveness in a South Asian country.
Extending the gleaner–opportunist trade‐off
Authors: Yamamichi Masato , Letten Andrew D. 
Published: September 2022

Abstract

Species exhibit various trade‐offs that can result in stable coexistence of competitors. The gleaner–opportunist trade‐off to fluctuations in resource abundance is one of the most intuitive, yet also misunderstood, coexistence‐promoting trade‐offs. Here, we review its history as an ecological concept, discuss extensions to the classical theory and outline opportunities to advance its understanding.

The mechanism of coexistence between species that grow relatively faster than their competitors in a low‐resource environment (i.e. a gleaner) versus a high‐resource environment (i.e. an opportunist) was first proposed in the 1970s. Stable coexistence could emerge between gleaners and opportunists if the opportunist species (dominant in unstable environments) dampens resource fluctuations via relatively convex functional responses, while the gleaner species (dominant in stable environments) promotes fluctuations, or diminishes them less than the opportunist does, via relatively saturating functional responses.

This fluctuation‐dependent coexistence mechanism has since been referred to by various names, including the Armstrong–McGehee mechanism and relative nonlinearity of competition. Several researchers have argued this mechanism likely plays a relatively minor role in species coexistence owing in part to the restricted range of conditions that allow it to operate. More recent theoretical research, however, suggests that relative nonlinearity can operate over wider conditions than previously thought.

Here, we identify several novel, or little explored, extensions to the gleaner–opportunist trade‐off that can yield species coexistence under phenomena as diverse as fluctuations in predation/pathogen pressure, multiple resources, phenotypic plasticity and rapid evolution, amongst other phenomena.

While the original definition of the gleaner–opportunist trade‐off may be imperfect as a collective for these extensions, we argue that a subtle reframing of the trade‐off focusing on species' performance in equilibrium versus fluctuating conditions (irrespective of preferences for high or low resources, predation pressure or other competitive factors) reveals their fundamental commonality in stable coexistence via relative nonlinearity. An extended framing shines a light on the potential ubiquity of this canonical trade‐off in nature and on the breadth of theoretical and empirical terrain that remains to be trodden.
The experience and role of mentorship for paediatric occupational therapists
Authors: Jackson Olivia , Villeneuve Michelle , Millington Michael 
Published: September 2022

AbstractIntroductionWithin Australia, the introduction of the National Disability Insurance Scheme has led to a growth in paediatric occupational therapists working in community settings. This growth has increased the demand for support from more senior paediatric occupational therapists to novice clinicians. Mentoring has long been valued by occupational therapists as a means to provide this support. Despite its apparent benefit, there is limited research on the contribution of mentoring as distinct from supervision, and its impact on mentees' skills and confidence in providing care. This study examined the contribution of mentorship to the development of professional capability in paediatric occupational therapy practice from the perspective of mentors and mentees.MethodsInterpretive description methodology was used. In‐depth interviews were conducted with nine mentors and eight mentees from three Australian states. Data were analysed inductively and thematically.FindingsAll participants reflected on the challenges presented by the complexity of practice, requiring a knowledge base that mentees perceived they did not possess. The essential nature of non‐judgemental, emotional support allowed mentees to feel safe to discuss their concerns when they were often overwhelmed by practice. Mentorship was viewed as capacity building, building competence by scaffolding clinical reasoning and supporting theory to practice translation while developing resilience to cope with complexity.ConclusionStudy participants reported that successful mentorship assisted novice practitioners to integrate knowledge and skills required for complex clinical and professional reasoning. The emotional support provided through the relationship supported novice therapists to build their confidence and resilience while promoting professional identity and socialisation into the profession. The study raised questions related to how the profession best supports novice paediatric therapists in the current employment contexts, and the need to review how bodies of knowledge relevant to paediatrics are brought together to be used by both novice clinicians and senior therapists, who support them, for translation to effective practice.
Review: Vegetation history of Cryptomeria japonica in Japan since the last interglacial period
Authors: Takahara Hikaru , Ikeda Shigeto , Sasaki Naoko , Hayashi Ryoma 
Published: September 2022

AbstractThe natural distribution of Japanese cedar (Cryptomeria japonica) has been disturbed by human activities, owing mainly to its value as timber; thus, its position in the vegetation zone of Japan is not clear. Therefore, it is important to determine the history of C. japonica forests before human influence. We reviewed the transitions in distribution and abundance of C. japonica in the Japanese Archipelago since the last interglacial period by using published pollen data. During the last interglacial, temperate deciduous broadleaf forests developed on northeastern Honshu Island, whereas on southwestern Honshu Island C. japonica populations increased, accompanied by warm‐temperate evergreen broadleaf trees. During the first half of the last glacial period, C. japonica forests developed throughout the Japanese Archipelago except on Hokkaido. Thereafter, 60,000–30,000 years ago, C. japonica covered the area around Lake Biwa and the Izu Peninsula. During the Last Glacial Maximum, C. japonica was most abundant on the Izu Peninsula, and small refugial populations were located along the coast of the Sea of Japan from southwestern to northeastern Honshu, and along the Pacific coast of Shikoku Island. During the Middle Holocene, C. japonica populations increased rapidly in southwestern Honshu. Two thousand years ago, before the intensification of human activities, C. japonica was widespread in warm‐ to cool‐temperate zones on the Sea of Japan side of Honshu, the Izu Peninsula, the Pacific coast of Shikoku Island, and Yakushima Island. This evidence indicates that C. japonica is one of the major tree species in the Japanese vegetation zone.
Nowcasting the Australian Labour Market at Disaggregated Levels
Authors: Shamiri Samuel , Ngai Leanne , Lake Peter , Shan Yin , McMillan Amee , Smith Therese , Sharma Kishor 
Published: September 2022

AbstractDetailed labour market and economic data are often released infrequently and with considerable time lags between collection and release, making it difficult for policy‐makers to accurately assess current conditions. Nowcasting is an emerging technique in the field of economics that seeks to address this gap by ‘predicting the present’. While nowcasting has primarily been used to derive timely estimates of economy‐wide indicators such as GDP and unemployment, this article extends this literature to show how big data and machine‐learning techniques can be utilised to produce nowcasting estimates at detailed disaggregated levels. A range of traditional and real‐time data sources were used to produce, for the first time, a useful and timely indicator—or nowcast—of employment by region and occupation. The resulting Nowcast of Employment by Region and Occupation (NERO) will complement existing sources of labour market information and improve Australia's capacity to understand labour market trends in a more timely and detailed manner.
Monitoring cell loss through repetitive deposition
Authors: Petcharoen Piyamas , Kirkbride Kenneth Paul , Linacre Adrian 
Published: September 2022

AbstractTouch DNA deposited on items can be visualised by using fluorescent nucleic acid staining dyes. It might be expected that if a person contacts items multiple times, then at each contact fewer cells should be transferred and deposited. Here we report on the use of Diamond Dye (DD) to monitor any reduction in cellular deposition during multiple contacts. A volunteer, who was assigned as a heavy shedder, was asked to deposit a thumbprint using both left and right thumbs for 15 s onto separate clean glass slides. Thumbprints were collected in triplicate with each mark made for 15 s. Immediately after deposition, a second and then third mark was made in the same way. The three consecutive depositions were repeated 30 times to create 90 tested thumbprints. The number of cells within each entire thumbprint was scored using a cell‐counting program, developed in‐house. The number of cells deposited by the second and third depositions showed a decrease in the cell number compared to the first deposition, by ~70% and ~85% respectively. There was no difference between the percentage of cell persistence from whole thumbprints (16 frames) compared to only scoring part of thumbprints (4 frames). The data obtained provide insight into how cells are deposited by touch and how many cells remain on the thumb for subsequent contact events. Such information may account for cell deposition when performing actions (e.g. loading a firearm or repetitively opening a closing zip‐lock bag).