bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomarkers in heart failure clinical trials. A review from the Biomarkers Working Group of the Heart Failure Association of the European Society of Cardiology
Authors: Bayes‐Genis Antoni , Aimo Alberto , Jhund Pardeep , Richards Mark , de Boer Rudolf A. , Arfsten Henrike , Fabiani Iacopo , Lupón Josep , Anker Stefan D. , González Arantxa , Castiglione Vincenzo , Metra Marco , Mueller Christian , Núñez Julio , Rossignol Patrick , Barison Andrea , Butler Javed , Teerlink John , Filippatos Gerasimos , Ponikowski Piotr , Vergaro Giuseppe , Zannad Faiez , Seferovic Petar , Rosano Giuseppe , Coats Andrew J.S. , Emdin Michele , Januzzi James L. 
Published: September 2022

AbstractThe approval of new heart failure (HF) therapies has slowed over the past two decades in part due to the high costs of conducting large randomized clinical trials that are needed to adequately power major clinical endpoint studies. Several biomarkers have been identified reflecting different elements of HF pathophysiology, with possible applications in diagnosis, risk stratification, treatment monitoring, and even in the design of clinical trials. Biomarkers could potentially be used to refine study inclusion criteria to enable enrolment of patients who are more likely to respond to a therapeutic intervention, despite being at sufficient risk to meet pre‐determined study endpoint rates. When there is a close relationship between biomarker levels and clinical endpoints, changes in biomarker levels after a given treatment can act as a surrogate endpoint, potentially reducing the duration and cost of a clinical trial. Natriuretic peptides have been widely used in clinical trials with a variable amount of added value, which such variation being probably due to the absence of a close pathophysiological connection to the study drug. Notable exceptions to this include sacubitril/valsartan and vericiguat. Future studies should seek to adopt unbiased approaches for discovery of true companion diagnostics; with ‐omics‐based tools, biomarkers might be more precisely selected for use in clinical trials to identify responses that closely reflect the biological effects of the drug under investigation. Finally, biomarkers associated with cardiac damage and remodelling, such as cardiac troponin, could be employed as safety endpoints provided that standardization between different assays is achieved.
Case study on demand side management‐based cost optimized battery integrated hybrid renewable energy system for remote rural electrification
Authors: Rajegowda Kalpana Dhavala , Hassan NageshaRao Suresh , Siddaiah Rajanna , Mala Ramesh 
Published: September 2022

AbstractPower demand of isolated villages where on‐grid power supply is not economical can be met by standalone renewable energy system. Hybrid renewable energy system (HRES) considered in the current study involves photo‐voltaic, wind turbine, diesel generator, and battery. In the present study, the demand side energy management methods are used for energy management. The load shifting and strategic conservation methods are used. The energy management schemes are applied in the stage of load estimation. It is observed in the analysis that, the net present cost (NPC) of $55 263 is reduced to $34 009 with the application of demand side energy management strategies. The two control strategies, load‐following and predictive‐dispatch strategy are incorporated. The three types of batteries like lead‐acid, lithium‐ion, and zinc‐bromide are integrated, one at a time, for analysis. The analysis results in the optimal HRES configuration solution with the combination of both load shifting and strategic conservation techniques of demand side energy management. The NPC is reduced by 37% in comparison with the HRES without the application of energy management methods. The zinc‐bromide battery integrated HRES configuration through predictive dispatch control strategy with the application of demand side energy management schemes results in optimal solution for electrification of cluster of villages located in Uralagallu panchayat, Sagar Taluk, Shivamogga District, Karnataka, India. To the similar kind of geographical condition areas, the same HRES configuration with similar approach can be extended for electrification.
RETRACTED: Improving mobile cloud computing service efficiency using energy competent and federated learning process
Authors: Thirunavukkarasu Mani , Shanmugapriya Prakasam 
Published: September 2022

AbstractMobile cloud computing (MCC) helps to make effective communication that is used to transmit various information like voice, data, and video. The MCC environments support different real‐time applications, including gaming and virtual reality implications. During the data transmission, energy conservation is one of the major issues for retaining the application span incorporating distributed and personalized computing and resource sharing. Ability‐sustained energy competent method (ASECM) is introduced to overcome these issues and manage energy efficiency. The ASECM approach analyzes the session span and energy requirements for managing the applications' energy factor. In addition, the federated learning and computation offloading process is incorporated to retain the energy factor for ensuring reliable services. The effective utilization of the offloading process is used to meet the application deadline and energy‐sufficient operations, preventing failures. In the recommendation process, cloud service availability with energy management constraints is considered for reducing energy expenditures. This process is nonrecurrent as the user/application requirements rely on diverse resources over different energy management techniques. The performance is measured using energy efficacy, utilization, application span, and failures.
GESLA Version 3: A major update to the global higher‐frequency sea‐level dataset
Authors: Haigh Ivan D. , Marcos Marta , Talke Stefan A. , Woodworth Philip L. , Hunter John R. , Hague Ben S. , Arns Arne , Bradshaw Elizabeth , Thompson Philip 
Published: September 2022

AbstractThis paper describes a major update to the quasi‐global, higher‐frequency sea‐level dataset known as GESLA (Global Extreme Sea Level Analysis). Versions 1 (released 2009) and 2 (released 2016) of the dataset have been used in many published studies, across a wide range of oceanographic and coastal engineering‐related investigations concerned with evaluating tides, storm surges, extreme sea levels, and other related processes. The third version of the dataset (released 2021), presented here, contains double the number of years of data, and nearly four times the number of records, compared to Version 2. The dataset consists of records obtained from multiple sources around the world. This paper describes the assembly of the dataset, its processing, and its format, and outlines potential future improvements.
Bonding and 13C‐NMR properties of coinage metal tris(ethylene) and tris(norbornene) complexes: Evaluation of the role of relativistic effects from DFT calculations
Authors: Muñoz‐Castro Alvaro , Dias H. V. Rasika 
Published: September 2022

AbstractThe π‐complexes of cationic coinage metal ions (Cu(I), Ag(I), Au(I)) provide useful experimental support for understanding fundamental characteristics of bonding and 13C‐NMR patterns of the group 11 triad. Here, we account for the role of relativistic effects on olefin‐coinage metal ion interaction for cationic, homoleptic tris‐ethylene, and tris‐norbornene complexes, [M(η2‐C2H4)3]+ and [M(η2‐C7H10)3]+ (M = Cu, Ag, Au), as representative case of studies. The M‐(CC) bond strength in the cationic, tris‐ethylene complexes is affected sizably for Au and to a lesser extent for Ag and Cu (48.6%, 16.7%, and 4.3%, respectively), owing to the influence on the different stabilizing terms accounting for the interaction energy in the formation of coinage metal cation‐π complexes. The bonding elements provided by olefin → M σ‐donation and olefin ← M π‐backbonding are consequently affected, leading to a lesser covalent interaction going down in the triad if the relativistic effects are ignored. Analysis of the 13C‐NMR tensors provides further understanding of the observed experimental values, where the degree of backbonding charge donation to π2*‐olefin orbital is the main influence on the observed high‐field shifts in comparison to the free olefin. This donation is larger for ethylene complexes and lower for norbornene counterparts. However, the bonding energy in the later complexes is slightly stabilized given by the enhancement in the electrostatic character of the interaction. Thus, the theoretical evaluation of metal‐alkene bonds, and other metal‐bonding situations, benefits from the incorporation of relativistic effects even in lighter counterparts, which have an increasing role going down in the group.
Simulation of ligand dissociation kinetics from the protein kinase PYK2
Authors: Spiriti Justin , Noé Frank , Wong Chung F. 
Published: September 2022

AbstractEarly‐stage drug discovery projects often focus on equilibrium binding affinity to the target alongside selectivity and other pharmaceutical properties. The kinetics of drug binding are ignored but can have significant influence on drug efficacy. Therefore, increasing attention has been paid on evaluating drug‐binding kinetics early in a drug discovery process. Simulating drug‐binding kinetics at the atomic level is challenging for the long time scale involved. Here, we used the transition‐based reweighting analysis method (TRAM) with the Markov state model to study the dissociation of a ligand from the protein kinase PYK2. TRAM combines biased and unbiased simulations to reduce computational costs. This work used the umbrella sampling technique for the biased simulations. Although using the potential of mean force from umbrella sampling simulations with the transition‐state theory over‐estimated the dissociation rate by three orders of magnitude, TRAM gave a dissociation rate within an order of magnitude of the experimental value.
Lnc2300 is a cis‐acting long noncoding RNA of CYP11A1 in ovarian granulosa cells
Authors: Wang Miaomiao , Wang Yang , Yao Wang , Du Xing , Li Qifa 
Published: September 2022

AbstractThe high level of progesterone and 17β‐estradiol ratio (P4/E2) in follicular fluid has been considered as a biomarker of follicular atresia. CYP11A1, the crucial gene encoding the rate‐limiting enzyme for steroid hormone synthesis, has been reported differently expressed in the ovary during follicular atresia. However, the regulation mechanism of CYP11A1 expression during follicular atresia still remains unclear. Here, we have demonstrated that lnc2300, a novel pig ovary‐specific highly expressed cis‐acting long noncoding RNA (lncRNA) transcribed from chromosome 7, has the ability to induce the expression of CYP11A1 and inhibit the apoptosis of porcine granulosa cells (GCs). Mechanistically, lnc2300, mainly located in the cytoplasm of porcine GCs, sponges and suppresses the expression of miR‐365‐3p through acting as a competing endogenous RNA (ceRNA), which further relieves the inhibitory effects of miR‐365‐3p on the expression of CYP11A1. Besides, CYP11A1 is validated as a direct functional target of miR‐365‐3p in porcine GCs. Functionally, lnc2300 is an antiapoptotic lncRNA that reduces porcine GC apoptosis by inhibiting the proapoptotic function of miR‐365‐3p. In summary, our findings reveal a cis‐acting regulation mechanism of CYP11A1 through lncRNA, and define a novel signaling pathway, lnc2300/miR‐365‐3p/CYP11A1 axis, which is involved in the regulation of GC apoptosis and follicular atresia.
Optimization and biochemical characterization of a thermotolerant processive cellulase, PtCel1, of Parageobacillus thermoglucosidasius NBCB1
Authors: Basak Arijita , Gavande Parmeshwar V. , Murmu Nensina , Ghosh Shilpi 
Published: September 2022

AbstractVermicomposting involves enrichment of microorganisms that are able to resist higher temperatures and perform simultaneous degradation of lignocellulose, and therefore, such microbial communities are a potential source of cellulolytic enzymes. This study aimed to optimize the production of a processive cellulase by Parageobacillus thermoglucosidasius NBCB1 isolated from vermicompost, under submerged fermentation of rice straw and to characterize the purified enzyme for industrial suitability. Cellulase production in basal medium (7.27 IU/mg) was enhanced to 61 IU/mg by One Factor At a Time approach, which was further improved to 78.46 IU/mg by genetic algorithm based artificial neural networking. The cellulase PtCel1 purified from bacterial culture showed a molecular weight of ≈33 kD, had activity on both crystalline (305 IU/mg) and amorphous (184 IU/mg) cellulose as substrates. It had pH and temperature optima of 5.5°C and 60°C, respectively, and retained 100% activity upon preincubation at 60°C for 1 h indicating thermostability. PtCel1 was tolerant to sodium dodecyl sulfate, glucose and mannose; and the various metal chlorides, such as sodium, magnesium, calcium and zinc, acted as inducers giving 77.54%, 45.15%, 61.10%, and 169.14% augmentation of activity, respectively. Its efficiency on cellulosic substrates and robustness against aforementioned chemical and thermal environment makes it suitable for industrial applications.
Investigating future changes in precipitation interannual variability and extremes over southern China
Authors: Liu Ying Lung , Tam Chi‐Yung , Tong Hang Wai , Cheung Kevin , Xu Zhongfeng 
Published: September 2022

AbstractThe Regional Climate Model system version 4 (RegCM4) has been used to dynamically downscale outputs from four different general circulation models (GCM) participating in the Coupled Model Intercomparison Project Phase 5 (CMIP5) to the horizontal resolution of 25 km × 25 km, in order to study changes in the Southern China hydrological cycle according to the Representative Concentration Pathway (RCP) 8.5 between 2050‐to‐2099 and 1979‐to‐2003. Accompanying wetter boreal spring and summer, the interannual rainfall variability for these seasons is also enhanced. A novel moisture budget analysis shows that changes in mean background humidity (anomalous wind convergence) dominate the increase in the interannual variability in spring (summer). Extreme daily precipitation in these seasons (based on the 95th percentile) is projected to become more intense, roughly following the Clausius–Clapeyron (CC) relation for the aforementioned seasons. On the other hand, the annual number of maximum consecutive dry days (CDD) is found to increase by about 3 to 5 days over locations south of 32° N, where autumn mean rainfall rate is projected to reduce (although this might be subjected to models' ability in capturing tropical cyclone activities). Analyses of the GCM raw outputs indicate that strengthened northerlies over coastal East Asia, which is likely associated with the so‐called tropical expansion, are responsible for the drier autumn.
Optimization of enzyme‐assisted extraction of albedo extract obtained from watermelon rind (Citrullus lanatus) and its use in the enrichment of nutrients and bioactive compounds in watermelon juices
Authors: dos Santos Gielen Delfino , da Silva Haas Isabel Cristina , Arriola Nathalia Darminia Aceval , Vitali Luciano , Fritzen‐Freire Carlise Beddin , de Oliveira Petkowicz Carmen Lucia , Amante Edna Regina , Prudêncio Elane Schwinden , Amboni Renata D. M. C. 
Published: September 2022

AbstractBackgroundAlbedo residue represents approximately 54% of the total solid residue generated during watermelon juice production, this material is an excellent source of bioactive compounds and polysaccharides. This study aimed at optimizing the enzyme‐assisted extraction (EAE) to obtain a higher yield of albedo extract using response surface methodology (RSM), having in view the enrichment of watermelon juice with this material.ResultsThe complete three‐level factorial design allowed the optimization of enzyme concentration, extraction time and temperature, leading to an optimal extraction of albedo extract at an enzyme concentration of 1.5 ml/Kg (w/w), extraction time of 45 min and temperature of 50°C. The watermelon juice enriched with 10% of albedo extract (WJ10) showed the highest polyphenolic potential and antioxidant capacity. The 13C NMR spectra confirmed the presence of homogalacturonans, xylogalacturonans and rhamnogalacturonans in the albedo extract. The watermelon juice enriched with 30% albedo extract (WJ30) obtained an increase of 47% and 216% in the content of galactose and uronic acids. HPLC‐RID analysis revealed that the addition of albedo extract in watermelon juice decreased the contents of sucrose, glucose and fructose. The multivariate chemometric analysis revealed the grouping of samples according to the bioactive composition and monosaccharide profile.ConclusionThere is a global demand for reducing organic residues in food industries, that way, the elaboration of products from residues obtained from food processing, rich in polyphenols and polysaccharides, such as albedo extract, represents a promising opportunity to develop innovative products and ingredients with high added value.
Planar substrate integrated waveguide‐based resonators and its usage to compact X‐band small phase noise oscillator
Authors: Nimehvari Varcheh Hamed , Rezaei Pejman , Kiani Sina 
Published: September 2022

AbstractThis study denotes a procedure of a small phase noise (SPN) oscillator employing three different substrate integrated waveguide (SIW) resonators as a frequency stabilization‐component. The SIW resonator as modifying phase noise (PN) is investigated and branchline coupler in the feedback loop is presented. The design technique to attain SPN usage for optimized efficiency is proposed. Then, three different X‐band SIW oscillators using a packaged GaAs FET transistor are planned. Due to the PN and compacting, the miniaturized conventional SIW (MCSIW) oscillator is selected. This MCSIW oscillator operates at 8.15 GHz, mentions a PN of −169 dBc/Hz at 1‐MHz frequency‐offset.
Influence of scour on the vertical response of rock‐socketed piles in layered saturated rock–soil mass
Authors: Chen Yuan Feng , Ai Zhi Yong , Ma Zhan Guo , Ye Zi Kun 
Published: September 2022

AbstractThe influence of scour on the vertical response of rock‐socketed piles in a layered saturated rock–soil mass is studied through the finite element‐boundary element coupling method. By utilizing the theoretical solution of layered saturated media as the kernel function, the boundary element method (BEM) is used to deduce the boundary integral equations of rock–soil mass. Meanwhile, the pile is modelled with the three‐node bar element and the global stiffness matrix of the pile is assembled by the finite element method (FEM). Then according to the scour type, the flexibility matrix of the foundation is recombined and extended, which is consistent with the stiffness matrix dimension of the pile. In consideration of the force balance and continuity conditions at the pile‐soil‐rock interface, the FEM–BEM coupling equation is established to solve the interaction between layered rock–soil mass and rock‐socketed pile that considers different scour types. A corresponding MATLAB program is compiled to verify the correctness of the present theory by comparisons with the existing literature solutions, field tests and the finite element solutions. The influences of the scour type, scour depth, socketed length as well as pile‐rock mass modulus ratio and rock mass stratification on the vertical response of a rock‐socketed single pile are further discussed through several numerical examples.
The association between body image, emotional health, relationships, and unhealthy dietary behaviors among medical sciences students: A structural equation modeling analysis
Authors: Arabi‐Mianrood Hoda , Shahhosseini Zohreh , Tabaghdehi Monirolsadate Hosseini 
Published: September 2022

AbstractAimAlthough it showed that poor body image may drive an individual to unhealthy dietary behaviors, but less is known about the role of emotional health and interpersonal relationships in this regard in different age group of population. This study aimed to investigate the association between body image, emotional health, relationships, and unhealthy dietary behaviors among medical sciences students.MethodsIn this cross‐sectional study, using a three‐stage stratified sampling method, 248 Iranian medical sciences students were recruited. The participants completed self‐administered questionnaires, including Youth Risk Behavior Survey Questionnaire, Adolescent Health Concerns Inventory, and Body Image Concern Inventory. The data were analyzed using SPSS‐20 and structural equation modeling in the Amos software version 24.ResultsThe results indicate the acceptability of the goodness of fit model index. Direct association of body image with emotional health (β = 0.91, p = 0.005) and relationships (β = 0.88, p = 0.009) was significant, but any direct and indirect association between body and unhealthy dietary behaviors was not found.ConclusionThis study underlines the importance of being aware of the association between body image, emotional health, and relationships Further studies are recommended to explore the relationship between these factors and unhealthy dietary behaviors in medical sciences students.
Self‐assembly, mesomorphic behavior, and ionic conductivity of polymerized ionic liquid crystals with a threshold switching characteristic
Authors: Tang Xinqiao , Chang Xiaolong , Zhu Boyan , Cui Luan , Jiang Beihong , Meng Fanbao , Yan Guiyang 
Published: September 2022

AbstractA series of pyridinium‐based polymerized ionic liquid crystals (PILCs) with different anions were synthesized, including poly(pyridinium bromide)s and poly(pyridinium trifluoroacetate)s, and their chemical structure, liquid‐crystalline properties and conductivity properties were investigated by many experimental techniques. At low temperature, some PILCs containing less cholesteryl mesogens presented smectic A phases; while the PILCs containing more cholesteryl mesogens displayed bicontinuous cubic phases. At high temperature, all the PILCs showed nematic phases. Compared with the corresponding poly(pyridinium bromide)s based on identical polymer cations, the poly(pyridinium trifluoroacetate)s showed lower glass transition and isotropic transition temperature. The PILCs displayed excellent temperature‐dependent ionic conductivity, making it attractive for applications in temperature‐controlled electronic switches. In cubic and smectic A phases, the PILCs presented Arrhenius‐like ionic conductivity behavior, and they exhibited Vogel–Fulcher–Tammann‐like behavior in nematic phases.