bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of the baseline level and change in glycosylated hemoglobin A1c with incident hypertension in non-diabetic individuals: a 3-year cohort study
Authors: Liu Lijuan , Zhen Donghu , Fu Songbo , Sun Weiming , Li Hongli , Zhao Nan , Hou Lijie , Tang Xulei 
Published: April 2022

Abstract
Background
Diabetes mellitus increases the risk of developing hypertension. The relationship between glycosylated hemoglobin A1c (HbA1c) level and incident hypertension remains controversial. This study examined the associations of the baseline level and change in the HbA1c level over 3 years with incident hypertension in non-diabetic individuals.

Methods
This community-based cohort study was conducted with 2591 individuals aged 40–75 years without hypertension or diabetes at baseline, who participated in a longitudinal (REACTION) study program. Questionnaires were administered during interviews, and anthropometric and laboratory measurements were performed at baseline (2011) and follow-up (2014–2015). Multivariate logistic regression models were applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of incident hypertension.

Results
Over a median follow-up period of 3.08 years (interquartile range 3.00, 3.25), 384 (14.82%) subjects developed hypertension. In the fully adjusted linear regression models, change in HbA1c remained significantly associated with changes in systolic blood pressure and diastolic blood pressure [β-coefficient (95% CI), 4.421 (2.811–6.032), 1.681 (0.695–2.667)]. Logistic regression analyses showed that baseline HbA1c level was positively associated with incident hypertension in the unadjusted model; however, the association was no longer significant after further adjustment. Change in HbA1c was positively associated with the development of hypertension, both as a categorical variable stratified by tertiles [adjusted OR (95% CI) in the highest tertile was 1.690 (1.240–2.303) versus the lowest tertile)] and as a continuous variable [adjusted OR (95% CI), 1.242 (1.106–1.394)], independent of age, sex, body mass index, systolic blood pressure, fasting plasma glucose level, lipid profile, the HbA1c level at baseline and 3-year change in body mass index.

Conclusions
A higher baseline HbA1c level was not an independent risk factor for incident hypertension, whereas the change in HbA1c was independently associated with a greater longitudinal increase in blood pressure and an increased risk of incident hypertension in non-diabetic individuals.
Oropharyngeal symptoms without systemic reactions as a risk factor for food allergen intolerance: a longitudinal pediatric study
Authors: Hamada Masaaki , Saeki Keigo , Sakurai Yoshihiko 
Published: April 2022

Abstract
Background
The determinants of tolerance to food allergens are not fully understood. We aimed to elucidate the longitudinal association between oropharyngeal symptoms without systemic reactions (OSw/oS) and tolerance to food allergens.

Methods
We included all patients diagnosed with single food allergy to egg (n = 121), milk (n = 55), and wheat (n = 41) using the oral food challenge test (OFC) from 2014 to 2017. These patients received oral immunotherapy at home and/or in the hospital after diagnosis by OFC. We compared the incidence proportion of tolerance within 2 years by OSw/oS and other variables for 217 patients with food allergy. We defined OSw/oS as isolated symptoms of oropharyngeal discomfort that occurred after ingestion of a safe dose of the allergenic food determined by the OFC in the first 6 months.

Results
Of the 217 patients (median age 37.5 months, male 64.5%), 53 developed OSw/oS (24.4%), and 151 (egg, 85 milk, 36 and wheat, 30) attained tolerance in 2 years. Patients without OSw/oS showed a significantly higher incidence of tolerance than those with the symptoms (crude hazard ratio [HR] 5.62, 95% confidence interval [CI] 3.58–8.82, p < 0.001). The association was consistently significant in the multivariable model (adjusted HR 9.50, 95% CI 5.25–17.20, p < 0.001) independent of other risk factors for intolerance, such as concomitant bronchial asthma (adjusted HR 3.33), history of anaphylaxis (adjusted HR 2.16), milk allergy (adjusted HR 2.02), and allergic symptoms with low dose OFC (adjusted HR 1.52).

Conclusion
Our results suggest that OSw/oS may be a risk factor for intolerance to food allergens. To reveal a high risk of food allergen intolerance may help patients and their families as well as healthcare professionals prepare for the challenge of continuing oral immunotherapy.
Is the relative thickness of ammonoid septa influenced by ocean acidification, phylogenetic relationships and palaeogeographic position?
Authors: Weber Céline , Hautmann Michael , Tajika Amane , Klug Christian 
Published: April 2022

AbstractThe impact of increasing atmospheric CO2and the resulting decreasing pH of seawater are in the focus of current environmental research. These factors cause problems for marine calcifiers such as reduced calcification rates and the dissolution of calcareous skeletons. While the impact on recent organisms is well established, little is known about long-term evolutionary consequences. Here, we assessed whether ammonoids reacted to environmental change by changing septal thickness. We measured the septal thickness of ammonoid phragmocones through ontogeny in order to test the hypothesis that atmosphericpCO2, seawater pH and other factors affected aragonite biomineralisation in ammonoids. Particularly, we studied septal thickness of ammonoids before and after the ocean acidification event in the latest Triassic until the Early Cretaceous. Early Jurassic ammonoid lineages had thinner septa relative to diameter than their Late Triassic relatives, which we tentatively interpret as consequence of a positive selection for reduced shell material as an evolutionary response to this ocean acidification event. This response was preserved within several lineages among the Early Jurassic descendants of these ammonoids. By contrast, we did not find a significant correlation between septal thickness and long-term atmosphericpCO2or seawater pH, but we discovered a correlation with palaeolatitude.
Larger 18F-fluoroboronotyrosine (FBY) active volume beyond MRI contrast enhancement in diffuse gliomas than in circumscribed brain tumors
Authors: Kong Ziren , Li Zhu , Chen Junyi , Ma Wenbin , Wang Yu , Yang Zhi , Liu Zhibo 
Published: April 2022

Abstract
Background
To investigate the relationship between 18F-fluoroboronotyrosine (FBY) positron emission tomography (PET)- and magnetic resonance imaging (MRI)-defined tumor volumes in contrast-enhanced diffuse gliomas and circumscribed brain tumors.

Methods
A total of 16 diffuse gliomas and 7 circumscribed brain tumors were included, and two types of three-dimensional regions of interest (ROIs), namely, MRI-based ROI (ROIMRI) and FBY-based ROI (ROIFBY), were semiautomatically defined. The overlap volume and DICE score were calculated to reveal the spatial relationship between the ROIMRI and ROIFBY.

Results
The ROIMRI was smaller than the ROIFBY and was mostly contained by the ROIFBY with an overlap volume of 0.995 ± 0.006 in the whole population. A significant difference in the DICE score was observed between circumscribed tumors and diffuse tumors (0.886 ± 0.026 vs. 0.684 ± 0.165, p = 0.004), and for the regions that have increased FBY metabolism but not MRI contrast enhancement, diffuse tumors and circumscribed tumors showed similar SUVmean values (0.630 ± 0.19 vs. 0.671 ± 0.18, p = 0.625).

Conclusion
FBY uptake beyond contrast enhancement is more significant in diffuse tumors than in circumscribed tumors, which may aid the delineation of active tumor areas and facilitate boron neutron capture therapy.
Nonspecific protection of heat-inactivated Mycobacterium bovis against Salmonella Choleraesuis infection in pigs
Authors: Vaz-Rodrigues Rita , Ferreras-Colino Elisa , Ugarte-Ruíz María , Pesciaroli Michele , Thomas Jobin , García-Seco Teresa , Sevilla Iker A. , Pérez-Sancho Marta , Mateo Rafael , Domínguez Lucas , Gortazar Christian , Risalde María A. 
Published: April 2022

AbstractTrained immunity is the capacity of innate immune cells to produce an improved response against a secondary infection after a previous unrelated infection. Salmonellosis represents a public health issue and affects the pig farming industry. In general, vaccination against salmonellosis is still facing problems regarding the control of distinct serovars. Therefore, we hypothesized that an immunostimulant based on heat inactivated Mycobacterium bovis (HIMB) could have an immune training effect in pigs challenged with Salmonella enterica serovar Choleraesuis (S. Choleraesuis) and decided to explore the amplitude of this non-specific immune response. For this purpose, twenty-four 10 days-old female piglets were randomly separated in three groups: immunized group (n = 10) received orally two doses of HIMB prior to the intratracheal S. Choleraesuis-challenge, positive control group (n = 9) that was only challenged with S. Choleraesuis, and negative control group (n = 5) that was neither immunized nor infected. All individuals were necropsied 21 days post-challenge. HIMB improved weight gain and reduced respiratory symptoms and pulmonary lesions caused by S. Choleraesuis in pigs. Pigs immunized with HIMB showed higher cytokine production, especially of serum TNFα and lung CCL28, an important mediator of mucosal trained immunity. Moreover, immunized pigs showed lower levels of the biomarker of lipid oxidation malondialdehyde and higher activity of the antioxidant enzyme superoxide dismutase than untreated challenged pigs. However, the excretion and tissue colonization of S. Choleraesuis remained unaffected. This proof-of-concept study suggests beneficial clinical, pathological, and heterologous immunological effects against bacterial pathogens within the concept of trained immunity, opening avenues for further research.
Mesenchymal stromal/stem cell therapy for radiation-induced salivary gland hypofunction in animal models: a protocol for a systematic review and meta-analysis
Authors: Jansson Per Marcus , Lynggaard Charlotte Duch , Carlander Amanda Fenger , Jensen Siri Beier , Follin Bjarke , Hoeeg Cecilie , Kousholt Birgitte Saima , Larsen Rasmus Tolstrup , Grønhøj Christian , Jakobsen Kathrine Kronberg , Rimborg Susie , Fischer-Nielsen Anne , Menon Julia M. L. , von Buchwald Christian 
Published: April 2022

Abstract
Background
Salivary gland (SG) hypofunction (objectively reduced saliva flow rate) and xerostomia (subjective sensation of dry mouth) are common and burdensome side effects of radiotherapy to the head and neck region. Currently, only sparse symptomatic treatment is available to ease the discomfort of xerostomia. The objective of this study is to assess the effect of mesenchymal stem cell (MSC) therapy on SG function after radiation-induced injury.

Methods
This systematic review will include animal intervention studies assessing efficacy and safety of MSCs in treating radiation-induced SG hypofunction. The primary outcome is the effect of MSC administration on salivary flow rates (SFR), by comparing treated groups to control groups when available. Secondary outcomes are morphological and immunohistochemical effects as well as safety of MSC treatment. Electronic searches in MEDLINE (PubMed) and Embase databases will be constructed and validated according to the peer review of electronic search strategies (PRESS) and assessed by two independent researchers. Data from eligible studies will be extracted, pooled, and analyzed using random-effects models. Risk of bias will be evaluated with the Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) risk of bias tool.

Discussion
Thus far, critical appraisal of MSC therapy as an effective treatment for SG hypofunction caused solely by radiation injury has not been conducted. A summary of the existing literature on preclinical studies concerning this issue can provide valuable information about effectiveness, mode of action, and safety, allowing further optimization of preclinical and clinical trials.

Systematic review registration
PROSPERO CRD42021227336
Quadruple fixed-point techniques for solving integral equations involved with matrices and the Markov process in generalized metric spaces
Authors: Hammad Hasanen A. , Abdeljawad Thabet 
Published: April 2022

AbstractThe goal of this manuscript is to establish quadruple fixed-point and coincidence-point consequences in the setting of generalized metric spaces equipped with vector-valued metrics and matrix equations. Moreover, some supportive examples and corollaries are presented here to support the theoretical results. Ultimately, the theoretical results are presented here to discuss some applications to support our study.
Existence and stability results for nonlocal boundary value problems of fractional order
Authors: Ertürk Vedat Suat , Ali Amjad , Shah Kamal , Kumar Pushpendra , Abdeljawad Thabet 
Published: April 2022

AbstractIn this paper, we prove the existence and uniqueness of solutions for the nonlocal boundary value problem (BVP) using Caputo fractional derivative (CFD). We derive Green’s function and give some estimation for it to derive our main results. The main principles applied to investigate our results are based on the Banach contraction fixed point theorem and Schauder fixed point approach. We dwell in detail on some results concerning the Hyers-Ulam (H-U) type and generalized H-U (g-H-U) type stability also for problem we are considering. We justify our results with an illustrative example.
Investigation of a time-fractional COVID-19 mathematical model with singular kernel
Authors: Adnan  , Ali Amir , ur Rahmamn Mati , Shah Zahir , Kumam Poom 
Published: April 2022

AbstractWe investigate the fractional dynamics of a coronavirus mathematical model under a Caputo derivative. The Laplace–Adomian decomposition and Homotopy perturbation techniques are applied to attain the approximate series solutions of the considered system. The existence and uniqueness solution of the system are presented by using the Banach fixed-point theorem. Ulam–Hyers-type stability is investigated for the proposed model. The obtained approximations are compared with numerical simulations of the proposed model as well as associated real data for numerous fractional-orders. The results reveal a good comparison between the numerical simulations versus approximations of the considered model. Further, one can see good agreements are obtained as compared to the classical integer order.
Complete controllability of nonlinear fractional neutral functional differential equations
Authors: Wen Yanhua , Xi Xuan-Xuan 
Published: April 2022

AbstractThis paper is concerned with the complete controllability of a nonlinear fractional neutral functional differential equation. Some sufficient conditions are established for the complete controllability of the nonlinear fractional system. The conditions are established based on the fractional power of operators and the fixed-point theorem under the assumption that the associated linear system is completely controllable. Finally, an example is presented to illustrate our main result.
Stakeholder interdependencies in a collaborative innovation project
Authors: Khan Iqra Sadaf , Kauppila Osmo , Fatima Noureen , Majava Jukka 
Published: April 2022

AbstractIndustry 4.0—also known as the modern industrial revolution—nurtures close collaboration between various organizations so that they can come together for innovation. While aiming for digital transformation through such innovation, these organizations form certain interdependencies due to the pool of resources and tasks they agree to share to reach both common and independent goals. To understand those interdependencies, we studied a national innovation project in Finland called “Reboot IoT Factory,” which leveraged several resources, processes, and practices to successfully combine modern technologies in manufacturing in a competitive and sustainable way. The participants included in the project were factories, research organizations, and small and medium enterprises (SMEs). An actor dependency model was used to analyze the observed interdependencies through survey and interview data. The results showed strong goal, task, and resource dependencies between the participants. A conventional understanding of advantages and opportunities, such as increased experience sharing and possible long-term synergies, is elaborated; moreover, an analysis of the disadvantages and risks caused by interdependencies, such as delays in tasks and possible inefficiency through unnecessary complexity, is also conducted.
Effect of Silica Fume on the Volume Expansion of Metakaolin-Based Geopolymer Considering the Silicon-to-Aluminum Molar Ratio
Authors: Park Sungwoo , Yu Juan , Oh Jae Eun , Pyo Sukhoon 
Published: April 2022

AbstractThis paper investigates the effect of silica fume on the mechanical properties of metakaolin-based geopolymers with different silicon-to-aluminum molar (S/A) ratios. Geopolymer has been extensively studied as an alternative to traditional cementitious material because of its low CO2 emissions. Previous studies revealed that the application of silica fume can improve the compressive strength of geopolymer, however, the optimum dosages are different. To examine the reason for the different optimum dosages of silica fume, this study prepares geopolymer specimens of which variables are the S/A ratio and silica fume dosage, and conducts compressive strength and initial setting time tests. To examine whether the strength degradation is caused by the expansion due to the added silica fume in geopolymer, the volume and dynamic modulus are also measured. The results show that a part of silica fume dissolves and changes the S/A ratio of geopolymer, and that a part of silica fume remains in the geopolymer matrix. These combined effects of silica fume result in an irregular compressive strength trend, and, thus, an optimum dosage of silica fume can vary depending on the S/A ratio. Furthermore, the volume expansion of geopolymer with silica fume is observed, however, no sign of damage on the compressive strength is found.
Carbendazim shapes microbiome and enhances resistome in the earthworm gut
Authors: Song Jiajin , Li Tongxin , Zheng Zhiruo , Fu Wenjie , Long Zhengnan , Shi Nan , Han Yuling , Zhang Luqing , Yu Yunlong , Fang Hua 
Published: April 2022

AbstractBackgroundIt is worrisome that several pollutants can enhance the abundance of antibiotic resistance genes (ARGs) in the environment, including agricultural fungicides. As an important bioindicator for environmental risk assessment, earthworm is still a neglected focus that the effects of the fungicide carbendazim (CBD) residues on the gut microbiome and resistome are largely unknown. In this study,Eisenia fetidawas selected to investigate the effects of CBD in the soil-earthworm systems using shotgun metagenomics and qPCR methods.ResultsCBD could significantly perturb bacterial community and enrich specific bacteria mainly belonging to the phylum Actinobacteria. More importantly, CBD could serve as a co-selective agent to elevate the abundance and diversity of ARGs, particularly for some specific types (e.g., multidrug, glycopeptide, tetracycline, and rifamycin resistance genes) in the earthworm gut. Additionally, host tracking analysis suggested that ARGs were mainly carried in some genera of the phyla Actinobacteria and Proteobacteria. Meanwhile, the level of ARGs was positively relevant to the abundance of mobile genetic elements (MGEs) and some representative co-occurrence patterns of ARGs and MGEs (e.g.,cmx-transposase andsul1-integrase) were further found on the metagenome-assembled contigs in the CBD treatments.ConclusionsIt can be concluded that the enhancement effect of CBD on the resistome in the earthworm gut may be attributed to its stress on the gut microbiome and facilitation on the ARGs dissemination mediated by MGEs, which may provide a novel insight into the neglected ecotoxicological risk of the widely used agrochemicals on the gut resistome of earthworm dwelling in soil.Graphical Abstract
Prompt and precise identification of various sources of infection in response to the prevention of malaria re-establishment in China
Authors: Yin Jianhai , Yan He , Li Mei 
Published: April 2022

AbstractPrompt and precise diagnosis of patients is an essential component of malaria control and elimination strategies, it is even more vital for the prevention of malaria re-establishment in the post elimination phase. After eliminating malaria in China, the strategy for prevention of malaria re-establishment was updated in a timely manner from the elimination strategy focusing on each case/focus to the prevention of re-establishment focusing on timely identification of the source of infection. However, there are numerous challenges, such as the persistent large number of imported malaria cases, the long-term threat of border malaria, unknown levels of asymptomatic infections and Plasmodium falciparum HRP2/3 gene deletions, and the continuous spreading of antimalarial drug resistance. Meanwhile, the detection capacity also need to be further improved to meet the timely detection of all sources of infection, otherwise it is bound to occur introduced malaria cases and malaria re-establishment in the presence of malaria vector mosquitoes. Therefore, it is necessary to continuously strengthen the malaria detection competency at all levels, promote the research and development on the malaria parasitological testing technologies, thus improving the timely detection of various sources of infection, and preventing the re-establishment of malaria.
Graphical abstract
Sintilimab for the treatment of non-small cell lung cancer
Authors: Zhang Lin , Lin Weihao , Tan Fengwei , Li Ning , Xue Qi , Gao Shugeng , Gao Yibo , He Jie 
Published: April 2022

AbstractAnti-programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) immunotherapy has dramatically changed the therapeutic landscape of inoperable non-small cell lung cancer (NSCLC), and has been included in first-line treatments. Sintilimab is a domestic anti-PD-1 monoclonal antibody in China that has received approvals from the National Medical Products Administration to treat classical Hodgkin’s lymphoma, hepatocellular carcinoma, and squamous and non-squamous NSCLC. In a prospective clinical study we led, neoadjuvant sintilimab has led to major and complete pathologic responses, which are recommended as surrogate endpoints for neoadjuvant immunotherapy; however, its effect remains inconclusive in pulmonary ground glass nodules. Meanwhile, combination plans seem more likely to be satisfying therapeutic options. Specifically, sintilimab plus platinum-based chemotherapy plans conferred better anti-tumor efficacy and clinical benefits compared to chemotherapy alone, which led to their approval in China and the acceptance of a biological license application in the US. Besides, the combination with other plans, such as docetaxel, cytokine-induced killer cell immunotherapy, radiation therapy, and anlotinib have also shown promising anti-tumor efficacy, with acceptable toxicities, and are therefore worth further exploration. In addition, several clinical trials on NSCLC at our center are ongoing. In general, sintilimab and its combinatorial plans were effective and well tolerated, but the treatment requires appropriate timing; pathologic responses can be surrogate endpoints for neoadjuvant immunotherapy, while more effective biomarkers are warranted. This study provides an overview of sintilimab-based clinical trials on NSCLC, and may support further investigation of sintilimab in future clinical trials.