bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conductive Hydrogel Conduits with Growth Factor Gradients for Peripheral Nerve Repair in Diabetics with Non‐Suture Tape
Authors: Cai Yuting , Huang Qun , Wang Penghui , Ye Kaichuang , Zhao Zhen , Chen Haomin , Liu Zhenjing , Liu Hongwei , Wong Hoilun , Tamtaji Mohsen , Zhang Kenan , Xu Feng , Jin Guorui , Zeng Lun , Xie Jianbo , Du Yucong , Hu Zhigang , Sun Dazhi , Qin Jinbao , Lu Xinwu , Luo Zhengtang 
Published: June 2022

AbstractDiabetic patients suffer from peripheral nerve injury with slow and incomplete regeneration owing to hyperglycemia and microvascular complications. This study develops a graphene‐based nerve guidance conduit by incorporating natural double network hydrogel and a neurotrophic concentration gradient with non‐invasive treatment for diabetics. GelMA/silk fibroin double network hydrogel plays quadruple roles for rapid setting/curing, suitable mechanical supporting, good biocompatibility, and sustainable growth factor delivery. Meanwhile, graphene mesh can improve the toughness of conduit and enhance conductivity of conduit for regeneration. Here, novel silk tapes show quick and tough adhesion of wet tissue by dual mechanism to replace suture step. The in vivo results demonstrate that gradient concentration of netrin‐1 in conduit have better performance than uniform concentration caused by chemotaxis phenomenon for axon extension, remyelination, and angiogenesis. Altogether, GelMA/silk graphene conduit with gradient netrin‐1 and dry double‐sided adhesive tape can significantly promote repairing of peripheral nerve injury and inhibit the atrophy of muscles for diabetics.
A Cancer Cell Membrane‐Derived Biomimetic Nanocarrier for Synergistic Photothermal/Gene Therapy by Efficient Delivery of CRISPR/Cas9 and Gold Nanorods
Authors: Huang Lin , Zhou Mengyang , Abbas Ghulam , Li Chao , Cui Mengmeng , Zhang Xian‐En , Wang Dian‐Bing 
Published: June 2022

AbstractBimodal synergistic therapy produces superadditive effect for enhanced therapeutic efficacy. However, how to efficiently and simultaneously deliver several kinds of therapeutic agents is still challenging. A cancer cell membrane‐derived nanocarrier (mCas9‐sGNRs) is proposed for synergistic photothermal/gene therapy (PTT/GT) by efficient delivery of clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR‐associated protein 9 (Cas9) and gold nanorods (GNRs). In this approach, Cas9 proteins can be efficiently loaded inside the cell membranes (mCas9) by electrostatic interactions. Similarly, single‐guide RNAs, which target survivin, can be loaded onto GNRs (sGNRs) through electrostatic interactions and encapsulated by mCas9. As a result, the nanodelivery systems present advantages in biocompatibility, homologous targeting capacity and loading efficiency of cargoes. In addition, significant antitumor effects is achieved by gene editing of survivin which induces anticancer activity and reduces heat tolerance of cancer cells caused by GNRs mediated PTT due to the downregulation of HSP70. These results indicate the nanotherapeutic platform leads to enhanced PTT/GT efficacy. Therefore, this work not only provides a general strategy to construct a versatile nanoplatform for loading and target delivery of several therapeutic cargos but will also be valuable for PTT/GT and other bimodal synergistic therapy.
Reprogramming Mitochondrial Metabolism in Synovial Macrophages of Early Osteoarthritis by a Camouflaged Meta‐Defensome
Authors: Zhang Lei , Chen Xiang , Cai Pingqiang , Sun Han , Shen Siyu , Guo Baosheng , Jiang Qing 
Published: June 2022

AbstractOsteoarthritis (OA) is a low‐grade inflammatory and progressive joint disease, and its progression is closely associated with an imbalance in M1/M2 synovial macrophages. Repolarizing pro‐inflammatory M1 macrophages into the anti‐inflammatory M2 phenotype is emerging as a strategy to alleviate OA progression but is compromised by unsatisfactory efficiency. In this study, the reprogramming of mitochondrial dysfunction is pioneered with a camouflaged meta‐Defensome, which can transform M1 synovial macrophages into the M2 phenotype with a high efficiency of 82.3%. The meta‐Defensome recognizes activated macrophages via receptor–ligand interactions and accumulates in the mitochondria through electrostatic attractions. These meta‐Defensomes are macrophage‐membrane‐coated polymeric nanoparticles decorated with dual ligands and co‐loaded with S‐methylisothiourea and MnO2. Meta‐Defensomes are demonstrated to successfully reprogram the mitochondrial metabolism of M1 macrophages by scavenging mitochondrial reactive oxygen species and inhibiting mitochondrial NO synthase, thereby increasing mitochondrial transcription factor A expression and restoring aerobic respiration. Furthermore, meta‐Defensomes are intravenously injected into collagenase‐induced osteoarthritis mice and effectively suppress synovial inflammation and progression of early OA, as evident from the Osteoarthritis Research Society International score. Therefore, reprogramming the mitochondrial metabolism can serve as a novel and practical approach to repolarize M1 synovial macrophages. The camouflaged meta‐Defensomes are a promising therapeutic agent for impeding OA progression in tclinic.
Intracellular Crowding by Bio‐Orthogonal Hydrogel Formation Induces Reversible Molecular Stasis
Authors: Macdougall Laura J. , Hoffman Timothy E. , Kirkpatrick Bruce E. , Fairbanks Benjamin D. , Bowman Christopher N. , Spencer Sabrina L. , Anseth Kristi S. 
Published: June 2022

AbstractTo survive extreme conditions, certain animals enter a reversible protective stasis through vitrification of the cytosol by polymeric molecules such as proteins and polysaccharides. In this work, synthetic gelation of the cytosol in living cells is used to induce reversible molecular stasis. Through the sequential lipofectamine‐mediated transfection of complementary poly(ethylene glycol) macromers into mammalian cells, intracellular crosslinking occurs through bio‐orthogonal strain‐promoted azide–alkyne cycloaddition click reactions. This achieves efficient polymer uptake with minimal cell death (99% viable). Intracellular crosslinking decreases DNA replication and protein synthesis, and increases the quiescent population by 2.5‐fold. Real‐time tracking of single cells containing intracellular crosslinked polymers identifies increases in intermitotic time (15 h vs 19 h) and decreases in motility (30 µm h−1 vs 15 µm h−1). The cytosol viscosity increases threefold after intracellular crosslinking and results in disordered cytoskeletal structure in addition to the disruption of cellular coordination in a scratch assay. By incorporating photodegradable nitrobenzyl moieties into the polymer backbone, the effects of intracellular crosslinking are reversed upon exposure to light, thereby restoring proliferation (80% phospho‐Rb+ cells), protein translation, and migration. Reversible intracellular crosslinking provides a novel method for dynamic manipulation of intracellular mechanics, altering essential processes that determine cellular function.
Homochiral Multiferroic Cyanido‐Bridged Dimetallic Complexes Assembled by C−F⋅⋅⋅K Interactions
Authors: Mao Yu , Chen Xiao‐Gang , Gu Zhu‐Xiao , Zhang Zhi‐Xu , Song Xian‐Jiang , Gu Ning , Xiong Ren‐Gen 
Published: June 2022

AbstractCyanido‐bridged dimetallic complexes are attracting attention due to their varied structures and properties. However, homochiral cyanido‐bridged dimetallic complexes are rare, and making them ferroelectric is a great challenge. Introducing C−F⋅⋅⋅K interactions between the guest chiral cations and the host [KFe(CN)6]2− framework, gives three‐dimensional cyanido‐bridged dimetallic multiferroics, [R‐ and S‐3‐fluoropyrrolidinium]2[KFe(CN)6] (R‐ and S‐3‐FPC). The mirror‐symmetric vibrational circular dichroism (VCD) signal shows their enantiomeric nature. R‐ and S‐3‐FPC crystallize in the same chiral‐polar space group P21 at 298 K. Piezoresponse force microscopy (PFM), polarizing optical microscopy, and temperature‐dependent second‐harmonic generation (SHG) measurements show their multiferroic properties (the coexistence of ferroelectricity and ferroelasticity), in line with the Aizu notation of 222F2. R‐3‐FPC shows excellent ferroelectricity with saturated polarization up to 9.4 μC cm−2.
Bioinspired Asymmetric Total Synthesis of Emeriones A–C**
Authors: Jänner Sven , Isak Daniel , Li Yuli , Houk Kendall N. , Miller Aubry K. 
Published: June 2022

AbstractWe report asymmetric bioinspired total syntheses of the fungal metabolites emeriones A–C via stereoselective oxidations of two bicyclo[4.2.0]octadiene diastereomers. The central bicyclic scaffolds are prepared in an 8π/6π electrocyclization cascade of a stereodefined pentaene, which contains the fully assembled side chains of the emeriones. The anti‐aldol side chain is made using a Paterson‐aldol addition, and the epoxide of the dioxabicyclo[3.1.0]hexane side chain via ring‐closure onto an oxidized acetal. Our work has enabled the structural revision of emerione C, and resulted in the synthesis of a “missing” family member, which we call emerione D. DFT calculations identified two methyl groups that govern torquoselectivity in the 8π/6π cascade.
Ultra‐Sensitive, Selective and Repeatable Fluorescence Sensor for Methanol Based on a Highly Emissive 0D Hybrid Lead‐Free Perovskite
Authors: Li Dong‐Yang , Song Jun‐Hua , Cheng Yu , Wu Xiao‐Min , Wang Yu‐Yin , Sun Chuan‐Ju , Yue Cheng‐Yang , Lei Xiao‐Wu 
Published: June 2022

AbstractA convenient and rapid detection method for methanol in ethanol remains a major challenge due to their indistinguishable physical properties. Herein, a novel fluorescence probe based on perovskite was successfully designed to overcome this bottleneck. We report a new zero‐dimensional (0D) hybrid perovskite of [MP]2InxSb1−xCl7 ⋅ 6 H2O (MP=2‐methylpiperazine) displaying an unusual green light emission with near‐unity photoluminescence quantum yield. Remarkably, this 0D perovskite exhibits reversible methanol‐response luminescence switching between green and yellow color but fail in any other organic vapors. Even for blended alcohol solutions, the luminescent probe exhibits excellent sensing performance with multiple superiorities of rapid response time (30 s) and ultra‐low detection limit (40 ppm), etc. Therefore, this 0D perovskite can be utilized as a perfect fluorescence probe to detect traces of methanol from ethanol with ultrahigh sensitivity, selectivity and repeatability. To the best of our knowledge, this work represents the first perovskite as fluorescence probe for methanol with wide potential in environmental monitoring and methanol detection, etc.
Anatomy informs geology: Hydrodynamic dispersal of alligator bones, with implications for taphonomic interpretations of fossil deposits of crocodylians, dinosaurs, and other morphologically novel taxa
Authors: Blob Richard W. , Espinoza Isabel Z. G. , Iijima Masaya 
Published: June 2022

AbstractDistinctive anatomical features of bones can influence not only how these structures perform in living animals but also the tendency of elements to be transported by flowing water after death. Such transport can be critical in the concentration of fossils from animals that live near freshwater habitats, providing important context for interpreting the composition of paleocommunities. Measurements of the tendency of flowing water to disperse skeletal elements have been collected for diverse taxa, including mammals, turtles, and birds. However, these extant models may not be entirely appropriate for many morphologically distinct extinct lineages, such as non‐avian dinosaurs. To expand the range of models available for evaluating the influence of hydrodynamic transport on the assembly of fossil deposits, we used a flow tank to measure the water speeds that disperse bones from a subadult American alligator (Alligator mississippiensis), with the skull and mandible tested in multiple starting orientations. Alligator bones are sorted into three main dispersal groups: early (vertebrae, most girdle elements), intermediate (ribs, most limb bones), and late (pubis, femur), with the skull and mandible varying between intermediate and late depending on orientation. Late dispersing elements tended to be heavy or very flat. These results can refine interpretations of the taphonomic context for deposits of fossil crocodylians and morphologically similar taxa (e.g., choristoderes, phytosaurs) and provide an additional comparative model for deposits of non‐avian dinosaurs. Moreover, variation in hydrodynamic sorting across lineages highlights how distinctive anatomical features can influence the concentration of fossils, shaping understanding of assemblage composition and paleofaunal evolution.
Current Insight into 3D Printing in Solid‐State Lithium‐Ion Batteries: A Perspective
Authors: Ponnada Srikanth , Babu Gorle Demudu , Chandra Bose Rapaka S , Sadat Kiai Maryam , Devi Meghali , Venkateswara Raju Chikkili , Baydogan Nilgun , Kar Nanda Karuna , Marken Frank , Sharma Rakesh K 
Published: June 2022

AbstractCompared to the state‐of‐art lithium‐ion batteries, the all‐solid‐state batteries offer improved safety along with high energy and power density. Although considerable research has been conducted, the inherent problems arising from solid electrolytes and the lack of suitable electrolytes hinder their development in practical applications. Furthermore, traditional synthesis routes have drawbacks due to limited control to fabricate the solid electrolytes with desired shape and size, impeding their maximum performance. In recent years, additive manufacturing or three‐dimensional (3D) printing techniques have played a vital role in constructing solid‐state batteries because of the rational design of functional electrode and electrolyte materials for batteries with increased performance. 3D printing in batteries may provide a new technology solution for existing challenges and limitations in emerging electronic applications. This process boosts lithium‐ion batteries by creating geometry‐optimized 3D electrodes. 3D printing offers a range of advantages compared to traditional manufacturing methods, including designing and printing more active and passive components (cathodes, anodes, and electrolytes) of batteries. 3D printing offers desired thickness, shape, precise control, topological optimization of complex structure and composition, and a safe approach for preparing stable solid electrolytes, cost‐effective and environmentally friendly.
Soft‐tissue landmarks for tibial baseplate rotational alignment in total knee arthroplasty: A cadaveric study
Authors: Eseonu Onyedikachi , Mactier Mhairi , Ferguson Eilidh , Quondamatteo Fabio , Blyth Mark , Jones Bryn 
Published: June 2022

AbstractThe tip of the tibial tubercle (TTT) is used to assess tibial baseplate rotation in total knee arthroplasty (TKA); however, it can be difficult to palpate and visualize intraoperatively. Several more easily accessible soft‐tissue structures have been proposed as intraoperative assessments, including the patellar tendon's medial border (MBPT) and the junction of the medial third of the patellar tendon (mt‐PT). No studies have described the relationship between the TTT and these proposed landmarks. The aims of the study were to (1) determine the relationship of the soft‐tissue landmarks to the TTT and (2) identify any sex differences in these measures. Measurements of the position of these soft‐tissue landmarks relative to the TTT were made on 56 cadaveric knees (28 female) by two observers at the level of the standard tibial cut (10 mm distal to the lateral tibial plateau). The results obtained were compared by sex and side. On average, 50.7% (SD 6.79, range 33.1%–63.1%) of the patellar tendon footprint was medial to the TTT. There were no significant differences between the sexes or left and right lower limbs. However, there was large variability in the position of all the soft‐tissue landmarks relative to the TTT. The results indicate that, on average, the patellar tendon footprint is evenly spread around the TTT. However, there is a large variability in the anatomical relationship between the soft‐tissue landmarks and the TTT. Caution is advised if relying on these structures intraoperatively.
Reversible, non‐plaque‐induced marginal bone loss around an osseointegrated implant: A case report
Authors: Lind Kristian H. , Ulvik Ingvild M. , Berg Einar , Leknes Knut N. 
Published: June 2022

AbstractThis case report documents a non‐plaque‐induced marginal bone loss around an osseointegrated implant. The loss of osseointegration, most likely caused by overload and/or suboptimal distribution of occlusal loading, may be reversed when the loading is reduced by optimally transmitting stress forces to the implant‐to‐bone interface and surrounding bone.
Single‐Stage Optimized Microwave‐Induced Activated Carbon from Coconut Shell for Cadmium Adsorption
Authors: Yusop Mohamad Firdaus Mohamad , Mohd Johan Jaya Erniza , Mohd Din Azam Taufik , Bello Olugbenga Solomon , Ahmad Mohd Azmier 
Published: June 2022

AbstractThe toxicity of heavy metals motivated the synthesis of coconut shell‐based activated carbon (CSAC) through single‐stage microwave irradiation technique to scavenge cadmium ions (Cd(II)). Response surface methodology revealed the optimum radiation power and radiation time which translated into 85.45 % of Cd(II) removal and 41.78 % of CSAC's yield. Isotherm and kinetic data were best described by Freundlich and pseudo‐first‐order (PFO) models, respectively. The changes of enthalpy, entropy, and activation energy were determined as well as the reduction of CSAC yield and Cd(II) removal after six regeneration cycles.
Visible‐Light Mediated Arbuzov‐Like Reaction with Thiophenols
Authors: Rahaman Rajjakfur , Nair Akshay M. , Volla Chandra M. R. 
Published: June 2022

AbstractWe hereby disclose, a visible light mediated addition of sulfenyl radicals to trialkyl phosphites to access functionalized phosphorothioates. The use of cheap and readily available Eosin Y as a photocatalyst under mild energy efficient conditions bypassing the use of external oxidants forms the chief highlight of the work. The protocol is scalable and mechanistic studies indicate that the reaction proceeds through an ionic‐Arbuzov like pathway from phosphoranyl radicals.
2D NMR‐based MatchNat Dereplication Strategy Enables Explosive Discovery of Novel Diterpenoid Alkaloids†
Authors: Yin Tian‐Peng , Yu Yi , Liu Qing‐Hua , Zhou Ming‐Yue , Zhu Guo‐Yuan , Bai Li‐Ping , Zhang Wei , Jiang Zhi‐Hong 
Published: June 2022

Comprehensive SummaryThe tribe Delphineae, comprising two genera, Aconitum L. and Delphinium L., is the richest source of bioactive diterpenoid alkaloids (DAs), while their highly similar chemical structures create a major challenge for dereplication from complex mixture. To solve the inefficient discovery process of natural DAs, a novel dereplication strategy based on pattern recognition of specific heteronuclear multiple bond correlation (HMBC) signals has been established in this study. This strategy utilized the diagnostic signals in the HMBC spectra of C19‐DAs, which could indicate the structural categories. The newly designed software MatchNat allowed in silico recognition of C19‐DA types. The developed dereplication system was demonstrated to be a practical strategy to dereplicate a variety of natural products from two Delphineae plants, including Aconitum vilmorinianum Kom. and Delphinium pachycentrum Hemsl. Known compounds could be rapidly recognized from the mixture, and novel DAs were found with the aid of MatchNat. Consequently, targeted isolation led to the explosive discovery of a series of novel DAs. This dereplication system has the potential to be adopted for dereplication of any other class of natural products and has shown promising application as a complementary tool in the nuclear magnetic resonance analysis of traditional Chinese medicines.
Accelerated mononuclear cell telomere attrition in breast cancer survivors with depression history: A 2‐year longitudinal cohort study
Authors: Carroll Judith E. , Olmstead Richard , Haque Reina , Irwin Michael R. 
Published: June 2022

BackgroundCancer treatments are thought to accelerate biological aging, although this trajectory is highly variable. Depression is more prevalent in breast cancer survivors and is thought to be a vulnerability factor for biological aging. A lifetime history of depression and cumulative lifetime number of depression episodes could hypothetically be associated with an accelerated rate of biological aging as indexed by attrition of telomere length in a prospective cohort of breast cancer survivors who were not currently depressed.MethodsBreast cancer survivors (n = 206) without current depression were recruited from a large community‐based health plan and were assessed for depression history by a structured diagnostic interview. Blood specimens were provided at baseline and every 8 months over 24 months to measure peripheral blood mononuclear cell (PBMC) telomere length. Mixed linear models examined associations of depression history and number of depression episodes with change in telomere length, adjusting for demographic, comorbidity, and cancer‐specific factors.ResultsIn the fully adjusted model, depression history predicted attrition of PBMC telomere length over 24 months (Beta [SE] = −.006 [.002], p = .001). Greater number of depressive episodes over the lifetime was also associated with accelerated attrition of PBMC telomere length over 24 months (Beta [SE] = −.004 [.001], p = .001).ConclusionsIn breast cancer survivors without current depression, telomere attrition over 24 months was greatest in those with a lifetime depression history, particularly those with the greatest number of episodes of major depressive disorder over their lifetime. Depression history and its cumulative burden may contribute to accelerated biological aging, with implications for risk of morbidity and mortality in breast cancer survivors.
Successful conversion surgery after FOLFIRINOX therapy in a patient with advanced pancreatic acinar cell carcinoma with a solitary peritoneal dissemination: A case report
Authors: Uemura Sunao , Maeda Hiromichi , Tanioka Nobuhisa , Yamaguchi Sachi , Munekage Masaya , Kitagawa Hiroyuki , Namikawa Tsutomu , Yamamoto Shota , Kohsaki Takuhiro , Iguchi Mitsuko , Uchida Kazushige , Hanazaki Kazuhiro 
Published: June 2022

AbstractBackgroundPancreatic acinar cell carcinoma is rare; it accounts for 1% of all malignant pancreatic exocrine tumors. Although surgical resection is an option for curative treatment, the safety and efficacy of conversion surgery in patients with pancreatic acinar cell carcinoma with metastasis remain unknown.CaseA 67‐year‐old man with epigastric pain and a pancreatic tumor was referred to our hospital. Computed tomography revealed a large tumor with a maximum diameter of 67 mm at the pancreatic head and a 23‐mm mass in the left upper abdominal cavity. Because a definitive diagnosis could not be made based on endoscopic ultrasonography‐guided fine needle aspiration biopsy findings, a diagnostic laparoscopy was performed. The tumor in the greater omentum at the left upper abdomen, resected under laparoscopy, was histopathologically diagnosed as pancreatic acinar cell carcinoma. Therefore, the pancreatic tumor was diagnosed as an unresectable pancreatic acinar cell carcinoma with a solitary peritoneal dissemination. The size of the main pancreatic tumor decreased to 15 mm after 18 courses of FOLFIRINOX (5‐fluorouracil, leucovorin, irinotecan, and oxaliplatin). Subsequently, the patient underwent conversion surgery, and the initial diagnosis of pancreatic acinar cell carcinoma was confirmed on pathological examination. The patient was discharged 31 days postoperatively, following which he received adjuvant chemotherapy with S‐1. No sign of recurrence has been observed for 32 months after surgical resection.ConclusionFOLFIRINOX may be effective in patients with pancreatic acinar cell carcinoma, and conversion surgery after FOLFIRINOX may be applicable to selective patients.