bluuebunny/crossref_metadata_2025_split huggingface dataset:
VIDĒRE EST CREDERE: LA STRUTTURA AD ALTA RISOLUZIONE DEL CANALE DEL PACEMAKER HCN4
Authors: Moroni Anna 
Published: January 2022

HCN channels (HCN1-4) generate the If current that controls automaticity and rhythm of the heartbeat. Using single-particle electron cryo-microscopy (cryo-EM), we obtained the structure of HCN4, bound and unbound to the cAMP ligand and with the pore in open and closed configuration. Analysis of the structures reveals a coordination site for the Mg2+ ion which, by linking two domains of the protein, facilitates channel gating by cyclic nucleotides. The open pore configuration used in molecular dynamics simulations provided information on the mechanisms of permeation of K+/Na+ ions and on the mechanism of action of ivabradine, a drug used in the treatment of angina.
Affinity study of -lactalbumin nanoparticles in a mixed solvent environment using Laplace transform technique
Authors: Kavitha K. , Palaniappan L. 
Published: January 2022

ABSTRACT. Effect of pH and cosolvent on the stabilization of protein structure is a well established study in protein or food science. Of the various interesting applications of protein nanoparticles, making it as a drug or bioactive compound carrier is of vital importance. This application of protein nanoparticle demands the affinity priority of protein with the available components of the medium. The basis of such studies lies in the synthesis of such protein nanoparticles and their characterizations. Secondly the knowledge of priority in affinity of protein to a particular solvent is essential. On this basis, the present work deals with the ultrasonic analysis of hydophobic interactions exhibited by the α-lactalbumin nanoparticle synthesised by heat treatment using acetone as desolvating agent. In order to enrich the variations in hydrophobicity, pH and cosolvent (fructose) are included in the study. The results are compared with one of our earlier work and are interpreted in terms of the interactions existing among the components and the evolved discussions reveal that the bulk nature of the medium is controlled by the existing hydrophobicity interactions. Further, as a novel attempt, the preference of protein particle to interact with a particular solvent in mixed solvent environment is elucidated using Laplace transform technique. This approach is expected to torch light in protein science in fixing the most desirable solvent in mixed solvent environment.

KEY WORDS: a-Lactalbumin, Fructose, Laplace Transform, Diffusion, Hydrophobic interactions

Bull. Chem. Soc. Ethiop. 2021, 35(3), 659-668.
DOI: https://dx.doi.org/10.4314/bcse.v35i3.16
Preparation, spectral study and antimicrobial activity of binary Co(II) complexes derived from 2’-hydroxy chalcones
Authors: Patil P. , Zangade S. 
Published: January 2022

ABSTRACT. The present work comprises preparation, characterization, thermal behavior and growth inhibitory activity of some novel Co(II) complexes derived from substituted (E)-1-(1-hydroxy-4-iodonaphthalen-2-yl)-3-phenylprop-2-en-1-one (L1) and (E)-1-(4-bromo-1-hydroxynaphthalen-2-yl)-3-phenylprop-2-en-1-one (L2-L6). Newly synthesized metal-ligand complexes were structurally confirmed with suitable spectroscopic technique such as FT-IR, EPR, NMR (both 1H and 13C). XRD analysis for complex C1 confirmed the crystal system; tetragonal and space group; P 42/n: 2 with unit cell dimensions a, b = 13.3516 Å, c = 10.8009 Å; α, β, γ = 90o. The IR and EPR study demonstrated that interaction between metal ions and ligand occurs through carbonyl oxygen and hydroxyl oxygen. From the values of magnetic moment (μ) it was observed that synthesized complexes (C1-C6) are paramagnetic with three unpaired electrons contain one electron in t2g orbital and two electrons in eg orbitals. Further all these complexes have been evaluated in-vitro for their antimicrobial activity against the Gram positive bacteria Staphylococcus aureus, Gram negative bacteria Escherichia coli and the yeast Candida albicans. The complex C1 showed the significant antimicrobial activity, whereas the complexes C2, C4, C5 and C6 are moderately active against the tested pathogens. The antimicrobial data revealed that growth inhibitory activities of complexes were enhanced comparatively than its respective ligands. The enhanced antimicrobial activity is attributed to the presence of halogens (Br, Cl, I) and hydroxyl (OH) active substituents associated with the basic nucleus of complexes. Therefore, the present study helps to develop a new class of antimicrobial analogues.

KEY WORDS: Metal complexes synthesis, 1,3-Diaryl-2-propene-1-one, Crystal structure, Thermal properties, Antimicrobial activity

Bull. Chem. Soc. Ethiop. 2021, 35(3), 513-524.
DOI: https://dx.doi.org/10.4314/bcse.v35i3.4
breve difesa dei diritti delle donne: por una reivindicación efectiva e igualitaria de los derechos de las ciudadanas
Authors: Gonzalez de Sande Mercedes 
Published: January 2022

El siglo XVIII será un período crucial en la lucha de las mujeres por la reivindicación de sus derechos. El espíritu revolucionario de la Ilustración había penetrado también en ellas, que anhelaban ansiosas la llegada de un giro definitivo que culminase en una transformación radical de la sociedad, donde, finalmente, hubiera cabida para ambos sexos en igualdad de condiciones. Sin embargo, la tan aclamada proclamación de la Declaración de los derechos del hombre y del ciudadano, aprobada en París, en 1789, ante todo pronóstico, las excluirá de la esfera de los derechos humanos.
Muchas fueron las reacciones en toda Europa contra tamaña injusticia, entre ellas la publicación, en Italia, en 1794, del tratado Breve difesa dei diritti delle Donne, del que daremos cuenta en el presente artículo.
Reingeniería de las herramientas de gestión en los servicios y su incidencia con la calidad de atención de los usuarios del Hospital “Walter Cruz Vilca” Alto Moche, Trujillo
Authors: Trujillo Cuidad Magna Rosa , Elías Silupu Jorge Wilmer , Cárdenas Rosales Carmen Rosa 
Published: January 2022

El objetivo del presente estudio fue determinar si la reingeniería de las herramientas de gestión en los servicios incide en la calidad de atención de los usuarios del Hospital “Walter Cruz Vilca” Alto Moche. Se llevó a cabo un estudio prospectivo, longitudinal, pre test – post test de tipo pre experimental en 296 usuarios externos a los cuales se les aplicó el SERVQUAL antes y después de la reingeniería de las herramientas gestión en el nosocomio mencionado. La calidad de atención de los usuarios del hospital “Walter Cruz Vilca” Alto Moche antes y después de la aplicación de la reingeniería a las herramientas de gestión en los servicios fue de 45,3 % y 56,8 %, con una mejora en la calidad de atención bajo a un 11,5 %. Se concluyó que la reingeniería a las herramientas de gestión en los servicios del Hospital Walter Cruz Vilca incide en la mejora en la calidad de atención percibida por el usuario externo en un 11,5 %.
El grado de conocimiento del personal administrativo sobre instrumentos de gestión en el Hospital Walter Cruz Vilca. Se evidencia que las frecuencias de categorización de grado regular (26,6 %) y malo (26,6 %) sumaron el 53,2 % de ellos, muy aparte de ser los porcentajes más altos en este grupo. El porcentaje de grados de conocimiento restantes fueron: excelente (13,3 %), muy bueno (20 %) y bueno (13,3 %). Si bien el grado de conocimiento fue en su mayoría bajo, la presente evidencia generó, además como parte del estudio, que la directora del nosocomio y el equipo de gestión aunado al personal administrativo establezcan una reingeniería de las estrategias sanitarias y la implementación de planes de mejora y el correspondiente seguimiento y monitorización de los mismos, a fin de mejorar la calidad de atención percibida por el usuario externo.
ANÁLISE DA MATURIDADE DO PROCESSO DE DESENVOLVIMENTO DE PRODUTOS ASSOCIADOS A INDÚSTRIA 4.0 NO MERCADO CAPIXABA ATRAVÉS DE PESQUISA APLICADA
Authors: Carvalho Flávio Lucio Santos de , Ferreira Juliana Loureiro 
Published: January 2022

O presente artigo teve como objetivo mensurar a maturidade do processo de desenvolvimento de produtos (PDP) no setor industrial do estado do Espírito Santo relacionando-o com a indústria 4.0, ou seja, verificar qual o conhecimento e aplicação das empresas capixabas no que tange o processo de desenvolvimento do produto, a aplicação dos conceitos de indústria 4.0 e como utilizam tais processos como uma vantagem competitiva para alavancagem de resultados, se destacando na Indústria capixaba, as empresas que tem como pilares a eficiência da produção e com abordagem PDP para se estabelecer no mercado. Logo, a forma com que as empresas encontram meios para alcançar tal objetivo, é o foco no processo de desenvolvimento do produto, que “se bem gerenciado pode contribuir decisivamente para a competitividade das empresas nesse ambiente” (JUGEND, 2006). Para sequenciar o projeto foram considerados três pilares do PDP: a eficiência da produção, o lead time e a flexibilidade da linha de montagem. Para isto, foi realizado uma triagem nas empresas com sede no Espírito Santo e foram avaliadas somente as que possui algum processo de desenvolvimento de produto. Neste sentido, tratou-se de analisar o posicionamento dessas empresas, demonstrar soluções e melhorias para o desenvolvimento de produto e a necessidade de um programa de aperfeiçoamento do processo de produtos. O resultado obtido foi a constatação da imaturidade do mercado quanto PDP e que o papel dos engenheiros de produção no desenvolvimento de produtos capixabas é pequeno se comparado aos demais profissionais que atuam no segmento de PDP e as empresas não utilizam todas as ferramentas de qualidade para o PDP.
The effect of music on sleep
Authors: Sluss Ashley Nicole , Beer Laura E. , Kwoun Soo-Jin 
Published: January 2022

Sleep is essential to human survival, yet issues with getting restful, consistent sleep is a common problem. One in three adults do not get the recommended amount of sleep1, creating myriad issues, from physical illness to mental and cognitive disorders, poor work attendance, and disruptions in daily life.2 Traumatic experiences that occur early in life can have life long health implications, including sleep disorders and insufficient sleep.3 With the advent of COVID-19, people in the United States and across the world were forced to quarantine themselves, thereby disturbing previously established norms of behavior, daily engagement with others, and sleeping habits. Being able to rejuvenate the physical, emotional, and mental state through sleep became more important yet also more difficult amidst the stresses of the pandemic.4Healthcare professionals are seeking alternate patient treatment forms regarding healthy sleeping patterns. Music is one solution to this ongoing problem because it is easily accessible, can be personalized to individual tastes, is cost effective, cost avoidant, and lacking in serious side effects. The focus of this article is to explain how music impacts sleep, sleep disorders, and to offer suggestions to optimize sleeping patterns through the conscientious application of music and music therapy. Keywords: sleep, music, health, sleep disorders, pandemic, music therapy
BERLAKU ADIL DALAM KEMEWAHAN: PEMBACAAN ATAS AM 6:1-7
Authors: . Kartono 
Published: January 2022

Abstract: In the Book of Amos, the picture of social life is so factual. Unfortunately, this situation is dominated by a problematic situation where people are being oppressed by the authorities, whoever they are. But what needs to be looked at is whether social justice was possible at that time? The answer is perhaps as championed by the prophets, including the Prophet Amos. So, what does fairness mean? The story of the Prophet Amos, who preached among the Israelites, offered a perspective of being fair amid luxury for humans today. This study aims to present the theme of justice in luxury life. The writing of this article uses the synchronic method with the help of G. Lenski’s theory and analyses the world of the text and the world in front of the text, then adds the repertoire of searching expert opinions synthesized by the author. It’s acceptable to live a luxurious life if it doesn’t hurt others; that’s the message of the Prophet Amos, the messenger of God. Living in luxury is not wrong; it’s just not right when it is obtained from the sacrifices and suffering of others and even exhibited for the needy (Am 4:1-3, 5:11-12, 8:4-6). The Israelites forgot that the luxury they got was a gift from God. Abstrak: Dalam Kitab Amos gambaran hidup sosial itu begitu nyata. Sayangnya gambaran itu didominasi oleh situasi yang memprihatinkan yakni masyarakat mengalami penindasan oleh penguasa. Tetapi yang perlu dicermati ialah apakah mungkin keadilan sosial itu terjadi di masa itu? Jawabannya jelas mungkin sebagaimana diperjuangkan oleh para nabi, termasuk oleh Nabi Amos. Lalu, berlaku adil yang seperti apa yang dimaksud? Kisah Nabi Amos yang mewartakan di antara orang-orang Israel menawarkan kaca pandang berlaku adil di tengah kemewahan bagi manusia zaman ini. Penelitian ini hendak menyajikan tema keadilan dalam kemewahan. Penulisan artikel ini menggunakan metode sinkronis dengan bantuan teori G. Lenski dan menganalisa dunia di dalam teks dan di luar teks, kemudian menambah khasanah dari penelusuran pendapat para ahli yang disintesiskan oleh penulis. Hidup mewah boleh, asal tidak menyengsarakan sesama, seperti itu pesan Nabi Amos, sang utusan Allah. Hidup dalam kemewahan itu tidak salah, hanya saja tidak tepat di kala didapatkan dari pengorbanan dan penderitaan orang lain bahkan dipamerkan bagi yang berkekurangan (Am 4:1-3, 5:11-12, 8:4-6). Bangsa Israel lupa kalau kemewahan yang didapatkannya itu merupakan pemberian dari Allah.
ELEMENTS OF TALENT MANAGEMENT IN THE INSURANCE SECTOR
Authors: Kajwang Ben 
Published: January 2022

Purpose: The insurance industry is one of the industries that have experienced digital transformations, the emergence of insurtech startups, and an aging workforce and the recent Covid-19 pandemic which has forced employers to rethink their talent-management strategies. Companies have also realized that talent management is a critical element of competitive advantage and a motivating force for business success. The goal of this study is to identify and analyze the elements of talent management in the insurance sector. The purpose of this work is to enable the readers understand the elements that make up and contribute to talent management and their impact on the organization’s performance.
Methodology: A desktop literature review was used for this purpose. Relevant journal articles for the study were identified using Google Scholar. The inclusion criteria entailed papers that were not over five years old.
Findings: It was found that there is a positive and significant influence of talent management on the organizational performance and a competitive advantage. It is therefore necessary that HR managers in insurance firms should initiate the use of the concept of talent management in their business strategies so as to achieve the set organizational goals. It was also found that the researchers advocated organizations to implement talent attraction, talent identification and talent retention in order to develop and manage talent.
Unique contribution to theory, practice and policy: It is therefore recommended that HR managers in insurance firms should implement talent management strategies or a good talent management model that fits the demands and needs of the organization. In addition, they should provide a conducive environment to nurture, develop, retain and manage top talented staff.
APPLICATION OF DEVELOP DEPLOY CONNECT MODEL IN MANAGING TALENT IN THE INSURANCE SECTOR
Authors: Kajwang Ben 
Published: January 2022

Purpose: The Develop Deploy Connect Model is an overall timeline structure that focuses on every stage from acquiring competent talent until how it leads to employee retention. The main objective of this model is to enhance and improve the productivity of the available human capital and promote career development of employees. This model can be used by HR professionals who are passionate about the development of their firm's workforce, educators, trainers, project managers, leads and consultants. The goal of this study to discuss the importance of education and skills on performance of insurance sector. The purpose of this work is to application of develop deploy connect model in managing talent and make recommendations for the insurance sector.
Methodology: A desktop literature review was used for this purpose. Relevant journal articles for the study were identified using Google Scholar. The inclusion criteria entailed papers that were not over a decade old.
Findings: From the review, organizations that employ strategic training through skills development among staff, in accordance with job requirements, enhance employee participation to higher grade. It was found that offering induction training, on job training, mentorship training and career development has a significant influence on the employee retention in an organization. In light of this, application of the develop-deploy-connect model enhance and improve the productivity of the available human capital and promote career development of employees.
Unique contribution to theory, practice and policy: The study recommended that the Hr managers should also capitalize on sourcing and recruiting or holding onto the appropriate skills and capabilities, according to business needs. Additionally, they should engage Motivating and developing the talented personnel to match business requirements for higher levels of job satisfaction. Moreover, deploying and managing talents to match skills and experience with organizational may go a long way in enhancing organizational performance. the study further recommends that training programs should be undertaken after a systematic needs analysis, that emphasis should be placed on training programs for all employees, that the training programs improved employee knowledge skills and attitudes and that there should be a continuous review of training programs and activities to meet the changing needs of the market.
IMPORTANCE OF EDUCATION AND SKILLS ON PERFORMANCE OF INSURANCE SECTOR
Authors: Kajwang Ben 
Published: January 2022

Purpose: The main indicators for performance measurement in the insurance companies are employee satisfaction, employee training time growth rate, employee reasonable proposal growth rate and the number of products developed. As the insurance sector experiences drastic technological changes, the employability skills and academic qualifications required for hiring and retaining employees have also changed. The goal of this study to discuss the importance of education and skills on performance of insurance sector. The purpose of this work is to enhance the reader’s understanding on the various ways that HR managers employ to improve the skills of their employees which contributes to the overall performance.
Methodology: A desktop literature review was used for this purpose. Relevant seminal references and journal articles for the study were identified using Google Scholar. The inclusion criteria entailed papers that were not over five years old.
Results: From the findings, researchers have advocated for insurance companies to engage their employees on continuous trainings and systematic development of skills that contribute to improved welfare of their employees and increased organizational productivity and profitability. It is therefore necessary that HR managers invest in human resource practices such as trainings and rewards, personnel development, in order to enhance productivity and the overall performance of the organization.
Recommendations: The study recommended that consistent trainings and systematic development of skills should be provided in all the levels of the insurance sector. In addition, insurance sector should train their employees on the use of system software such as ERP system that enables employees carry out their tasks faster and efficiently and as a result contribute to the overall performance.
PENERAPAN METODE JIGSAW DALAM MENINGKATKAN KEMAMPUAN KOGNITIF PESERTA DIDIK PADA MATA PELAJARAN IPA DI MI NW LINGKUK BUAK
Authors: Husairi Husairi , Hannan Abdul 
Published: January 2022

Pemilihan metode pembelajaran yang bervariasi bertujuan untuk membantu peserta didik agar dapat mencapai tujuan pembelajaran. Metode Jigsaw merupakan salah satu metode yang dapat dijadikan metode alternatif untuk mendorong peserta didik lebih aktif dan belajar bekerjasama dengan pasangannya. Tujuan penelitian ini yaitu untuk menguji metode talking stick dalam mengembangkan hasil belajar peserta didik di MI NW 1 Kembang Kerang Aikmel Lombok Timur.
Penelitian ini termasuk jenis penelitian tindakan kelas. Populasi sekaligus sampel dalam penelitian ini adalah peserta didik kelas IV MI NW Lingkuk Buak yang berjumlah 21 peserta didik. Teknik pengumpulan data dalam penelitian ini meliputi observasi, dokumentasi, angket, dan tes. Teknik analisis data yang di gunakan untuk uji hipotesis dalam penelitian ini berupa siklus-siklus PTK Kurt Lewin. Dengan hasil siklus I diperoleh ketuntasan klasikal 71,42%, dan siklus II dengan presentasi ketuntasan belajarnya mencapai 76,19 %, dan siklus III ≥ 85%. dengan demikian tujuan yang diinginkan pada hasil belajar telah tercapai yaitu ketuntasan belajar ≥ 85%. Hal ini menunjukkan penelitian berhasil sesuai dengan indikator ketercapaian. Keberhasilan dari penelitian ini tentunya tidak terlepas dari metode pembelajaran yang digunakan guru untuk meningkatkan hasil belajar siswa, serta peran guru yang melakukan refleksi dengan baik, sehingga penelitian ini berhasil dilakukan.
Penerapan Metode Simulasi Untuk Membantu Siswa Dalam Melaksanakan Shalat Fardu Lima Waktu Dengan Baik dan Benar di Kelas VII B MTs NW Karang Baru
Authors: Mardiana Lina 
Published: January 2022

Materi shalat fardu merupakan salah satu materi yang sangat urgen sekali dalam Kurikulum Pendidikan Agama Islam yang harus tercapai secara tuntas kepada 3 ranah yaitu kognitif, afektif dan psikomotorik. Agar tercapainya 3 ranah tersebut maka haruslah menggunakan metode yang tepat dalam proses pembelajaran dan harus disesuaikan dengan kondisi lingkungan sekitar. Masih Banyaknya siswa-siswi kelas VII B MTs Nahdlatul Wathan Karang Baru yang belum bisa melaksanakan shalat fardu dengan baik dan benar. Jika dibiarkan berlarut-larut maka siswa-siswi tidak akan pernah mengetahui tata cara sholat yang baik dan benar, Untuk mengatasi masalah ini, peneliti tertarik menggunakan metode simulasi untuk membantu siswa dalam melaksanakannya. Maka dari itu peneliti mengangkat judul penerapan metode simulasi untuk membantu siswa dalam melaksanakan sholat fardu lima waktu dengan baik dan benar. Hasil dari penelitian menunjukan bahwa pada siklus I ketercapaian daya serap siswa mencapai 66,9% dari 24 siswa dan tingkat ketuntasan klasikal siswa dalam simulasi sholat lima waktu hanya mencapai 32,5% atau hanya 11 siswa saja. sedangkan pada siklus II ketercapaian daya serap siswa mencapai 73,7% tingkat ketuntasan klasikal siswa dalam mensimulasi sholat lima waktu mencapai 71,% atau 23 siswa. Pada mata pelajaran fikih pada kompetensi ini sudah meningkat walaupun belum mencapai 99,9%. Perubahan yang terjadi dari siklus I ke siklus II menunjukkan bahwa menggunakan metode simulasi sudah efektif dilakukan