bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparação do efeito da suplementação de vitamina D e metformina nos sintomas da síndrome dos ovários policísticos
Authors: Moss Larissa Adriane dos Santos , Gonçalves Pollyanna Lourdes Felix Munarim Hauser , Freitas Francisca Marta Nascimento de Oliveira , Ferreira José Carlos de Sales 
Published: May 2022

Introdução: A síndrome dos ovários policísticos (SOP) é caracterizada como uma doença endócrina, reprodutiva e metabólica, trata-se de uma desordem complexa e heterogênea com prevalência de 5 a 10 % em mulheres em idade reprodutiva. Objetivo: Este estudo tem como objetivo avaliar o efeito da suplementação de vitamina D comparado ao uso do medicamento metformina nos sintomas da Síndrome dos Ovários Policísticos. Metodologia: Esta pesquisa se caracteriza como descritiva. Resultados e Discussão: A metformina é uma medicação muito utilizada no tratamento dos sintomas da SOP. Já a vitamina D é um pró-hormônio muito conhecido pela função de homeostase do cálcio e fósforo, ainda, está relacionado com prevenção e tratamento de diversas doenças, inclusive, também está relacionado com a melhora dos sintomas da SOP. Conclusão: Foi verificado benefício nas duas abordagens, entretanto, há diferenças enquanto os efeitos colaterais e a quantidade de estudos para comprovação de eficácia.
Conhecimento e comportamento dos cirurgiões-dentistas da Atenção Primária a Saúde do Município de Cascavel – PR referente às lesões suspeitas e neoplasias bucais malignas
Authors: Veronezzi Matheus Chaves , Vila Verde Luís Henrique Cerqueira , Bastiani Felipe Gustavo de , Marchi Paulo Guilherme Bittencourt , Ju Hsu Chen 
Published: May 2022

Objetivo: Analisar o conhecimento e comportamento dos cirurgiões-dentistas (CD’s) atuantes na Atenção Primária à Saúde (APS) do Município de Cascavel - PR, quanto a detecção precoce e manejo de lesões suspeitas e neoplasias bucais malignas. Métodos: Trata-se de um estudo transversal, descritivo e com abordagem quantitativa. A coleta de dados foi realizada através de questionário estruturado entregue aos CD`s atuantes na APS do município de Cascavel – PR entre os meses de julho e novembro de 2021. Resultados: Tiveram adesão a pesquisa 30 profissionais dos quais 80% avaliaram seu conhecimento como regular. Sendo que apenas 23,3% utilizam esses conhecimentos para realizar exame clínico detalhado com atenção para detecção de lesões bucais em todos os pacientes. Além disso, apesar de grande parte (90,7%) indicar positivamente sobre sentir-se seguro em orientar os pacientes quanto a prevenção e autoexame, apenas 16,7% indicou realizar sempre essas orientações. Conclusão: A maior parte dos profissionais entrevistados possui conhecimento satisfatório sobre o câncer bucal, ao mesmo tempo que demonstram fragilidade quanto ao comportamento referente as ações voltadas para educação e detecção precoce do câncer bucal. Evidenciando a necessidade de ações para que as fragilidades e inseguranças desses profissionais sejam superadas.
UMA REFLEXÃO SOBRE A BUSCA POR UMA COMUNICAÇÃO IMUNE A MAL-ENTENDIDOS NAS AULAS DE MATEMÁTICA
Authors: Silva Paulo Vilhena da , Silveira Marisa Rosâni Abreu da , Cruz Jaqueline Valerio da 
Published: May 2022

É natural, em nossa formação docente, almejarmos a melhor maneira de ensinar, um método de ensino pelo qual todos os discentes pudessem aprender. Em nossa experiência como formadores de professores de Matemática, não é raro que sejamos questionados a respeito de comoensinar de modo que todos aprendam. A despeito dos vários desafios que envolvem o ensino e o aprendizado dessa disciplina, seria possível um modo de comunicar no qual nunca haveria a possibilidade de mal-entendidos na compreensão? Buscando refletir sobre tal indagação, faremos umensaio teórico fundamentado na filosofia da linguagem de Ludwig Wittgenstein, intentando mostrar que essa busca pela “comunicação perfeita” traz consigo uma demanda pela essência, reflexo da adoção de um modelo referencial da linguagem, motivo de problemas, seja na Filosofia, seja na Educação, conforme apontam Wittgenstein e os comentadores de sua filosofia.
Synthesis of Fluorescent Copper Nanomaterials and Detection of Bi3+
Authors: Wu Rihan , Ai Jun , Ga Lu 
Published: May 2022

Based on the aggregation-induced luminescence of glutathione-protected non-noble metal copper nanoparticles (GSH-CuNPs), a fluorescence method for the rapid detection of bismuth (Bi3 +) was developed. The fluorescence intensity of GSH-CuNP solution is good, and the fluorescence can be quenched in the presence of Bi3 +. Based on this principle, a fluorescence mean for the admeasurement of Bi3+was built. The linear range was 0–100 mmol/L, and the detection limit was 10 mmol/L. The method is simple, rapid, and selective and can be used for the qualitative detection of Bi3 +.
Advances in the Synthesis and Superconductivity of Lanthanide Polyhydrides Under High Pressure
Authors: Guo Jianning , Chen Su , Chen Wuhao , Huang Xiaoli , Cui Tian 
Published: May 2022

Room-temperature superconductors have long been the ultimate goal of scientists. Pressure-stabilized hydrides are a new rapidly growing class of high-temperature superconductors and are believed to be a new superconducting system, undoubtedly leading to a surge in the discovery of new hydrogen-rich materials. They are the forefront of physics and material science. Lanthanide polyhydrides formed under pressure are promising conventional superconductors. Especially, both the theoretical and experimental reports on lanthanum superhydrides under pressure, exhibiting superconductivity at temperatures as high as 250 K, have further stimulated an intense search for room-temperature superconductors in hydrides. This review focuses on the recent advances of crystal structures, stabilities, and superconductivity of lanthanide polyhydrides at high pressures, including the experimental results from our group. By using in situ four-probe electrical measurements and the synchrotron X-ray diffraction technique, we have identified several high-temperature superconducting phases: a lanthanum superhydride and two cerium superhydrides. The present work indicates that superconductivity declines along the La–Ce–Pr–Nd series, while magnetism becomes more and more pronounced. These discoveries have enriched the binary system of clathrate superhydrides and provided more hints for studying the role of rare earth metal elements having high-temperature superconductivity.
The Association Between Total Percent Fat and Serum Uric Acid in Adults
Authors: Sun Juan , Yue Chenyang , Liu Zhen , Li Jie , Kang Weiming 
Published: May 2022

BackgroundSerum uric acid (SUA) has been proven to be closely associated with metabolic abnormalities, including obesity. This study aimed to investigate the detailed relationship between total percent fat (TPF) and SUA among adults.MethodsBriefly, 23,715 adults aged 18–59 years in the National Health and Nutrition Examination Survey (NHANES) 1999–2018 were included in this study. Multivariable linear regression models were used to examine the association between TPF and SUA. Subgroup analyses stratified by sex and obesity status were also performed by multivariable linear regression. Then, fitted smoothing curves and generalized additive models were also applied to address the non-linear relationship between TPF and SUA. Finally, a recursive algorithm was used to calculate the inflection point in the non-linear relationship and a two-segment piecewise linear regression model was used to analyze the relationship between TPF and SUA on both sides of the inflection point.ResultsThere were 15,808 (66.7%) obese individuals in all 23,715 participants. In the fully adjusted model, there was a positive association between TPF and SUA (β = 0.99, 95% CI: 0.73–1.26). Besides, this positive association remained statistically significant in subgroup analyses stratified by sex and obesity status. Interestingly, in males, the association of TPF and SUA was an inverted U-shaped curve (inflection point: 34.3%).ConclusionOur study revealed a significant positive relationship between TPF and SUA among adults and this association remained statistically significant when stratified by sex and obesity status, but the shape of the smoothing curve in males differed from that in females.
Modeling for the Stringency of Lock-Down Policies: Effects of Macroeconomic and Healthcare Variables in Response to the COVID-19 Pandemic
Authors: Santini Giunio , Fordellone Mario , Boffo Silvia , Signoriello Simona , De Vito Danila , Chiodini Paolo 
Published: May 2022

BackgroundThe spread of COVID-19 has been characterized by unprecedented global lock-downs. Although, the extent of containment policies cannot be explained only through epidemic data. Previous studies already focused on the relationship between the economy and healthcare, focusing on the impact of diseases in countries with a precarious economic situation. However, the pandemic caused by SARS-CoV-2 drew most countries of the world into a precarious economic situation mostly caused by the global and local lock-downs policies.MethodsA discriminant analysis performed via partial least squares procedure was applied to evaluate the impact of economic and healthcare variables on the containment measures adopted by 39 countries. To collect the input variables (macroeconomic, healthcare, and medical services), we relied on official databases of international organizations, such as The World Bank and WHO.ResultsThe stringency lock-down policies could not only be influenced by the epidemical data, but also by previous features of the selected countries, such as economic and healthcare conditions.ConclusionsIndeed, economic and healthcare variables also contributed to shaping the implemented lock-down policies.
Case Report: Extensive Temporal Bone Invasion in a Giant Vestibular Schwannoma
Authors: Lyu Fang , Gan Jinlu , Wang Haijun , Zhao Hongyang , Wang Lei , Zhang Fangcheng 
Published: May 2022

BackgroundRare giant vestibular schwannomas (GVSs) invade the temporal bone extensively, which carries unique risks for surgery owing to their complicated relationship with adjacent structures, difficult dissection of the temporal bone, and high risk of complications. The underlying mechanism of this invasive behavior remains unknown.Case descriptionWe report on a 28-year-old woman who presented with typical hearing loss and facial paralysis (House-Brackmann II). Magnetic resonance imaging exhibited a giant mass (∼5.0 cm) in the right cerebellopontine angle (CPA), petrous apex, and middle cranial fossa. Her primary diagnosis was GVS with petrous apex invasion. With the aid of presurgical imaging reconstruction and intraoperative facial nerve monitoring, we adopted a sequential therapeutic strategy, which included microsurgery for the CPA lesion followed by gamma knife radiosurgery (GKRS) for the petrous mass. During follow-up, stable tumor control was achieved with functional preservation of the facial nerve and no other complications. The postoperative immunohistochemical examination demonstrated dramatic intratumoral inflammation, which suggested its potential role in bony erosion. We reviewed the literature of large vestibular schwannoma with a petrous invasion and further discussed its treatment.ConclusionMicrosurgery remains the top therapeutic strategy for GVS. However, gross total resection with functional preservation of cranial nerves is challenging to achieve once the temporal bone is involved. In this case, we applied a planned and sequential approach of microsurgery and GKRS with a promising outcome, which highlighted this combinational strategy in this rare situation. In addition, pathological examination suggested that intratumoral inflammation might play a role in the bony erosion of GVS. Longer observation and more cases are needed to further investigate its molecular mechanism and treatment plan.
STRATEGI PENGEMBANGAN AGROINDUSTRI COKLAT PADA UD. UIH KEC. LAMPA KAB. POLEWALI MANDAR
Authors: Basri Zulkifli , Kusmiah Nurhaya 
Published: May 2022

AbstractChocolate is a processed food derived from cocoa beans which is included in the complex food category, the type of chocolate can be classified according to its composition, where this processed food contains important components including total fat, total solids and total milk solids. Chocolate as a processed food is favored by consumers of all ages, so the demand for this product continues to increase, and the presence of chocolate products is one of the factors in increasing income. This study aims to analyze the business position and development strategies that can be applied to the industry based on its business position. The method used in this research is descriptive qualitative with data processing using SWOT analysis, IFAS/EFAS and AHP. Based on the research that has been done, the IFAS value is 1.89 and the EFAS matrix value is 1.83, where is the position of the chocolate industry business in quadrant II or product diversification. From the data obtained, it can be concluded that this business is nottoo good in terms of utilizing strengths to overcome weaknesses, and has not been able to take advantage of opportunities to overcome threats. The strategy offered is based on the IFAS/EFAS matrix, namely making product innovations that are in accordance with consumer needs, expanding partner cooperation and mentoring in order to increase human resource capacity.Keywords : Chocolate, Agroindustry, SWOT, EFAS/IFAS AbstrakCokelat merupakan makanan olahan yang berasal dari biji kakao yang termasuk dalam kategori pangan yang kompleks, jenis cokelat dapat diklasifikasikan sesuai dengan komposisinya, dimana makanan olahan ini mengandung komponen yang penting diantaranya total lemak, total padatan dan total padatan susu. Cokelat sebagai makanan olahan digemari oleh konsumen dari semua aspek usia, sehingga permintaan akan produk ini terus meningkat, dan keberadaan produk cokelat menjadi salah satu faktor peningkatan pendapatan. Penelitian ini bertujuan untuk menganalisis posisi usaha dan strategi pengembangan yang dapat diterapkan pada industri berdasarkan posisi usahanya. Metode yang digunakan dalam penelitian ini yakni deskriptif kualitatif dengan pengolahan data menggunakan analisis SWOT matriks IFAS/EFAS dan diagram analisis SWOT . Berdasarkan penelitian yang telah dilakukan diperoleh nilai pada matriks ifas sebesar 1,89 dan nilai pada matriks EFAS yakni 1,83, dimana posisi dari usaha industri coklat berada pada kuadran ii yang menunjukkan kategori diversifikasi produk. Dari data yang diperoleh dapat disimpulkan bahwa usaha ini belum terlalu baik dalam hal memanfaatkan kekuatan untuk mengatasi kelemahan, dan belum mampu memanfaatkan peluang untuk mengatasi ancaman. Strategi yang ditawarkan berdasarkan analisis SWOT matriks IFAS/EFAS dan diagram analisis SWOT yakni membuat inovasi produk yang sesuai dengan kebutuhan konsumen, melakukan perluasan kerjasama mitra dan pendampingan dalam rangka peningkatan kapasitas SDM.Kata kunci: Cokelat, Agroindustri, Analisis SWOT, IFAS/EFAS
Aktivitas Fisik Pada Pasien Gagal Jantung Selama Masa Pandemi COVID-19
Authors: Istiqomah Istiqomah Istiqomah , Damanik Chrisyen , Abdurrahman Abdurrahman 
Published: May 2022

Latar Belakang: Penyakit gagal jantung menyebabkan penurunan curah jantung yang menyebabkan gangguan pada vaskularisasi dan aliran darah sehingga mempengaruhi kebutuhan aktivitas fisik secara metabolik. Aktivitas fisik mempunyai peran dalam keberhasilan pengobatan gagal jantung dan dapat memberi dampak bermakna dalam perbaikan gagal jantung. Tujuan: Mengidentifikasi gambaran Aktivitas Fisik Pasien Gagal Jantung di masa Pandemi COVID-19 Metode: Penelitian Kuantitatif dengan desain Deskriptif dilaksanakan dengan pendekatan Cross sectional dilakukan pada bulan Juni s.d Juli 2020, melibatkan 35 responden diambil menggunakan teknik concecutive sampling. Pengumpulan data menggunakan kuesioner International Physical Activity Questionaire Long Form (IPAQ-LF) dengan kriteria inklusi pasien telah didiagnosa selama 6 bulan, pasien dengan kelas NYHA I dan II. Hasil.Sebagian besar pasien gagal jantung memiliki aktivitas fisik berat sebanyak 23 orang(65,7%), namun sebanyak 7 orang (20,0%) memiliki aktivitas fisik sedang dan 5 orang (14,3%) memiliki aktivitas fisik rendah . Data didapatkan dari responden yang sebagian besar berusia antara 45-59 tahun, responden laki-laki 19 orang dan perempuan 16 orang dengan Klasifikasi NYHA I 15 orang dan NYHA II 20 orang . Kesimpulan: Sebagian besar responden memiliki tingkat aktivitas fisik yang tinggi. Saran: Bagi peneliti selanjutnya dapat meneliti faktor-faktor yang mempengaruhi aktivitas fisik selama masa pandemic COVID-19.
Korelasi Pruritus Uremik Dengan Kualitas Hidup Pasien End Stage Renal Disease Yang Menjalani Hemodialisi di Rumah Sakit Samarinda
Authors: Alex Alex , Safitri Kiki Hardiansyah , Layun Marina Kristi 
Published: May 2022

Latar Belakang: Pruritus uremik adalah masalah klinis end stage renal disease dengan hemodialisis, pruritus uremik berdampak pada gangguan tidur, sosial, kenyamanan, pekerjaan rumah dan tugas yang dapat mengganggu kualitas hidup. Kualitas hidup adalah kesejahteraan fisik, psikologis, sosial, serta kepuasan tingkat fungsi, kontrol penyakit, dan persepsi makna kehidupan. Tujuan: Mengetahui arah korelasi pruritus uremik dengan kualitas hidup pada pasien end stage renal disease yang menjalani hemodialisis. Metode: Penelitian ini menggunakan metode Correlation dengan Consecutive sampling. Jumlah responden sebanyak 31 dengan kriteria pasien penderita pruritus uremik, pasien tanpa penyakit kulit lain, pasien tanpa penyakit terminal lain dan pasien yang tidak menjalani kemoterapi. Pengukuran variabel dilakukan dengan menggunakan kuesioner 12-Item Pruritus Severity Scale dan WHOQoL-HDLikia. Hasil: Penelitian ini didapatkan hasil analisis nilai mean pruritus uremik (9.58(SD=2,884)) dan nilai mean kualitas hidup (71,77(SD=9,794)). Nilai p-value = 0,007 dan nilai r = 0,47 Kesimpulan: Terdapat korelasi positif pruritus uremik dengan kualitas hidup pasien end stage renal disease yang menjalani hemodialisis yang berarti semakin baik angka pruritus uremik maka akan semakin baik kualitas hidup pasien end stage renal disease yang menjalani hemodialisis. Kualitas hidup yang baik pada penelitian ini sangat dipengaruhi oleh kesehatan psikologis dan spiritual yang baik.
Studi Fenomenologi Aspek Spiritualitas Pada Pejuang Kanker Serviks
Authors: Diyella Nuzul Prima , Sulistyorini Wahyu Dewi , Rahayu Anik Puji 
Published: May 2022

Latar Belakang : Kanker serviks akan mempunyai gejala yang membuatnya tidak nyaman dari segi fisik dan psikologis yang menyebabkan pejuang kanker sangat sensitif dengan berbagai perasaan cemas, takut akan kematian. Timbulnya dampak tersebut munculnya kebutuhan spuritualitas untuk menemukan tujuan dan makna kehidupan agar lebih mendekatkan dirinya pada tuhannya untuk menguatkan dirinya agar tetap iklas dan mampu mengahadapi penyakitnya. Tujuan : Untuk mengeksplor lebih dalam “Bagaimana aspek spiritualitas pada pejuang kanker serviks. Metode : Kualitatif dengan pendekatan fenomenologi. Pengambilan partisipan menggunakan teknik purposive sampling dengan jumlah partisipan sebanyak 4 orang partisipan dengan kriteria inklusi yaitu seorang penderita kanker serviks, usia diatas umur 30 tahun, pejuang kanker serviks yang tidak mengalami penurunan kesadaran, pejuang kanker serviks yang tidak mengalami perburukan gejala yang tidak terkontrol, pejuang kanker serviks yang melakukan pengobatan rutin, pejuang kanker serviks yang tidak keberatan dilakukan wawancara, pejuang kanker serviks yang bisa menggunakan Handphone Hasil : Penelitian ini menghasilkan 4 tema utama yaitu keyakinan bahwa penyakit datangnya dari Tuhan, ibadah memberikan energi positif, harapan untuk keselamatan diri dan keluarga, kebermanfaatan untuk orang lain. Kesimpulan : Proses Spiritualitas akan muncul sendirinya disetiap individu dengan adanya agama, keimanan, harapan, trasedensi dengan adanya hal itu penderita kanker bisa menerima penyakitnya dengan mendekatkan diri pada Tuhan.
Niveles de vitamina D en pacientes con obesidad y COVID-19
Authors: Tenas Arana Daniel Isaias 
Published: May 2022

OBJETIVO: describir la importancia sobre niveles de vitamina D en pacientes con obesidad diagnosticados con COVID-19. MÉTODO: se fundamentó en la búsqueda de la literatura en disponibles bases de datos como artículos científicos de Jama, Elsevier, Nature, New England. RESULTADOS: la vitamina D disminuye la tormenta de citoquinas y la activación de linfocitos T, que ocurre en infecciones por COVID-19. Los pacientes obesos con COVID-19 tienen el riesgo de 2 veces de contraer COVID-19 y 2 veces de desarrollar un desenlace severo; pacientes con niveles insuficientes de vitamina D tienen riesgo de 1 vez de desarrollar severidad clínica mientras que el riesgo de mortalidad en pacientes obesos con niveles insuficientes de vitamina D es de 1 vez. Se recomienda que los niveles de vitamina D se encuentren mayor a 38 ng/ml para disminuir el riesgo de infecciones respiratorias agudas. CONCLUSIONES: la 1,25-dihidroxivitamina D a nivel pulmonar inhibe la producción de citoquinas, regula la activación de células T y metaloproteinasas de matriz. Los niveles óptimos de vitamina D brindan protección pulmonar, mediante la reducción del microambiente inflamatorio producido por citoquinas en pacientes obesos con COVID-19, disminuyendo su morbilidad y mortalidad.
The Rights to Health Of Worker From the Perspective of Indoor Air Quality
Authors: Amriyati Amriyati 
Published: May 2022

Indoor air quality really effects persons’ health, including workers whose time mostly spent at work. Persons’ conduct may create pollutant which effect indoor air quality. Unhealthy indoor air has caused more than four million people dead from pneumonia, stroke, systemic heart decease, obstructive lung decease and cancer. Persons’ conduct must be regulated by law to ensure one’s rights and obligation do not violate others. This research was focused on how the rights to health of the workers from the perspective of indoor air quality was protected by law and what obligations were generated from the rights towards workers, employers and the state. This research was an analytical descriptive doctrinal one using library research to gain secondary data from related legislation and regulation as well as expert commentaries in textbooks and scientific journal articles. To ensure indoor air quality for workers, the workers themselves and the employers must be equipped with the knowledge and comprehension of the rights they possess and the obligation attached with the rights to implement the law on how they have to conduct to ensure the participation in the availability of healthy indoor air quality. Workers and employers shall not act nor omit which might resulted in unhealthy indoor air at work room through ensuring fresh air circulation, avoiding smoke and other polluting substances use in indoor rooms.