bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Static and Dynamic Characteristics of the Electro-Hydraulic Pressure Servo Valve of Robot
Authors: Zhang Jianrui , Zhang Jun , Sun Yintong , Kang Jian , Pan Xiaonan 
Published: November 2022

Abstract
According to the characteristics of rotary direct drive electro-hydraulic pressure servo valve, the lumped parameter modeling and three-dimensional (3D) field analysis methods are integrated. The lumped parameter method is used for mathematical modeling for system parts with clear physical concept, and for complicate structures difficult to simply and derive, the 3D mathematical model is employed to analyze the magnetic field, flow field and structural field. Moreover, numerical fitting is carried out to the field analysis results, and the model recognition methods, such as neural network, are used for modeling. Specific mathematical algorithms are used to represent the mathematical relationship between the input parameters (such as structural parameters and environmental parameters) and the feature output parameters. Finally, the algorithm which can be used to evaluate the relationship between the input parameters (such as structural parameters and environmental parameters) of the analyzed object and its static and dynamic performances is obtained. For similar research objects, the user only needs to change the values of input parameters to complete the analysis and evaluation of the static and dynamic performances of system.
The influence of seasonal allergic conjunctivitis and its treatment on choroidal vascular index
Authors: Çallı Ümit , Çoban Fatih , Sevimli Neslihan 
Published: November 2022

Abstract
Background
To evaluate the the effects of seasonal allergic counjunctivitis (AC) and its treatment upon choroidal structure such as choroidal thickness (ChT) and choroidal vascular index (CVI) through the use of topical antihistamine agents.
Methods
The 60 eyes of 30 patients were included in the AC group. Another 30 patients were included in the control group. The choroid was imaged by using enhanced depth imaging optical coherence tomography (EDI-OCT) instrument without pupillary dilation. ChT was defined as the area between the outer hyperreflective border of the RPE and the sclerochoroidal border at the fovea, 750 µm temporal to the fovea and 750 µm nasal to the fovea. Image J was used to measure CVI. With the images obtained from EDI-OCT, the total choroidal area (TCA), luminal area (LA), stromal area (SA), and CVI were calculated using the binarization method.
Results
The mean ChT value in the AC group was 358.5 ± 93.8 µm at baseline and 356.8 ± 86.6 µm following 1 month of treatment. Meanwhile, the mean ChT in the control group was 316.6 ± 60.7 µm. The mean CVI value was 66.65 ± 2.98 in the control group, 70.75 ± 3.26 in the AC group at baseline, and 69.50 ± 3.17 following 1 month of treatment. Statistically significant difference was tracked between control and AC group (p = 0.028) and control group and posttreatment values (p = 0,031). There were no statistically significant difference between initial AC treatment values and posttreatment values for all of the measurements.
Conclusions
ChT and CVI can increase in patients with AC due to inflammation and increased vascular permeability. Although symptoms and signs related to AC may disappear after the treatment, effects in the choroid do not immediately normalize.
Functional outcomes of medial patellofemoral ligament reconstruction using the superficial quadriceps versus a hamstring autograft in patellar instability patients: a retrospective comparative study.
Authors: Sanguanjit Prakasit , Rujiraphum Possawat , Apivatgaroon Adinun , Chernchujit Bancha 
Published: November 2022

Abstract
Purpose

This study aims to compare the clinical outcomes between a superficial quadriceps autograft and a hamstring autograft.

Methods

A total of 47 consecutive patients with patellar instability, who underwent QA and HA for patellar stabilization at a specified center between 2012 and 2020, were retrospectively reviewed. The final radiographic and outcome measurements included; the knee’s range of motion and the Kujala and Lysholm scores were reviewed and analyzed with a minimum follow-up period of 12 months.

Results

22 QA and 25 HA patients met the eligibility criteria. There were 50% of males and females with a median age of 25 years (range 12–58) in the QA group, while 40% were males with a median age of 25 years (range 14–51) in the HA group. The mean follow-up period was 38.4 months (range 12–70) in QA and 59 months (range 16–96) in the HA group. At the final follow-up, no complications were observed with either technique. No patients presented with recurrent dislocations or subluxations after surgery. There was no statistically significant difference in postoperative mean Kujala scores (QA = 94.6 +/- 4.1 and HA = 94.0 +/- 7.6, p = 0.36) or the mean Lysholm scores (QA = 93.9 +/- 4.9 and HA = 93.0 +/- 6.6, p = 0.30).

Conclusion

MPFL reconstruction for patellar instability surgery using either QA or HA achieved good clinical outcomes during a minimum follow-up of 1 year. No significant differences in clinical outcome scores were observed in both groups.
Significantly Enhanced Dielectric and Energy Storage Performances of Epoxy Nanocomposites via Constructing Continuous 3D BaTiO3 Network Collaborated with Graphene Oxide
Authors: Bi Xueqing , Xue Wenqing , Wang Zhen , Wang Zi , Li Yuchao , Zhan Yanhu , Wang Shuangshuang , Hao Jigong , Li Wei , Han Weifang , Ge Bo , Ren Junwen , Zha Junwei 
Published: November 2022

Abstract
Three-dimensional (3D) ceramic network has advantages over conventional ceramic nanoparticles in achieving high-performance flexible polymer dielectrics. However, the energy storage capacity cannot be substantially improved due to the relatively large dielectric loss and low breakdown strength. In this study, hierarchical 3DBT/EP-GO (GEBT) dielectric hybrid composites with greatly improved permittivity and energy storage density were obtained by reversely introducing the mixed graphene oxide (GO)/epoxy (EP) solution into three-dimensional BaTiO3 (3DBT) network, which was facilely constructed by sol-gel method using cleanroom wiper as template. A relatively high dielectric constant (ε′ = 15.6) and breakdown strength (E0 = 239.8 kV·mm− 1) were simultaneously achieved for the GEBT-4 system with ~ 15.4 wt% of 3DBT and 0.75 wt% of GO (to the epoxy), which were much superior to the GEBT-1 with only 15 wt% 3DBT (ε′ = 9.2, E0 = 128.8 kV·mm− 1) and epoxy nanocomposite with even 25 wt% BT nanoparticles (ε′ = 6.3, E0 = 121.0 kV·mm− 1). The continuous 3DBT ceramic network provided effective polarization pathway within epoxy matrix, while GO was helpful to prevent electrical breakdown of composites, thereby resulting in the significantly enhanced energy storage performance.
Mathematical model and a block-centered difference approximation for a semiconductor device problem with heat and magnetic influences *
Authors: Yirang Yuan , Changfeng Li , Yunxin Liu 
Published: November 2022

Abstract
In this paper, we present a mathematical model with initial-boundary values and a block-centered approximation for a new semiconductor device type. Two factors, heat and magnetic influences are considered. This discussion is an important and basic simulation problem in information science. The mathematical model is formulated by four nonlinear partial differential equations (PDEs), determining four major physical variables. An elliptic equation is given for the potentials, two convection-diffusion equations are for the concentrations of electronic and hole, and a heat equation is for the temperature. The potentials affects the whole physical movement. The elliptic equation is treated by a block-centered method, and the law of conservation is preserved. The computational accuracy is improved one order. Other equations are convection-dominated, thus are approximated by block-centered differences. Furthermore, the unknowns and adjoint functions are computed at the same time. These characters play important roles in numerical computations of conductor device problems. Using the theories of priori analysis such as energy estimates, the principle of duality and mathematical inductions, an optimal estimates result is obtained. Thus, this important problem is solved.
MSC(2010) 65M06, 65N06, 65N30, 82D37
Identification and prediction of potential crucial genes and therapeutic drugs associated with preeclampsia
Authors: Huang Lei , Zhao Cheng 
Published: November 2022

Abstract
Background: Preeclampsia is a specific disease related to pregnancy that can cause severe maternal and fetal complications and is one of the leading causes of maternal and perinatal deaths. But its pathogenesis is not yet clear.
Objective: This study aimed to explore the potential genes and small molecule drugs of preeclampsia.
Methods: Gene expression profile(GSE160888) was acquired from the NCBI Gene Expression Omnibus. The microarray data included Preeclampsia, placenta, and normal placenta, which were analyzed to identify differentially expressed genes (DEGs) by R. The PPI network was constructed by using the STRING online database.The module analysis of PPI in MCODE screened out protein interaction modules. Then, Using R, these modules were analyzed again by using KEGG and GO enrichment analysis. Prediction of small-molecule drugs performed by CAMP. Finally, GSE102897 was used to verify the identified Hub genes.
Results: A total of 821 genes were identified after standardizing the microarray results, consisting genes of 416 upregulated and 405 downregulated. In total, two modules were identified, and five genes and five small-molecule drugs were selected.
Conclusion: In summary, we identified five hub genes that may be involved in the development and development of preeclampsia and screened out five potential small molecule drugs that have some significance for the treatment of preeclampsia.
Robust asbestos-free brake pad from eucalyptus fiber reinforced polybenzoxazine composites
Authors: Bubphachart Pavarit , Tiptipakorn Sunan , Jubsilp Chanchira , Jongvisuttisun Passarin , Rimdusit Sarawut 
Published: November 2022

Abstract
This study explored the development of a robust asbestos-free brake pad composite material from benzoxazine resin, eucalyptus fibers and other constituents. Two different samples involving bleached and unbleached eucalyptus fibers reinforced polybenzoxazine composites were produced, denoted by BEFPC and UEFPC respectively. The effects of bleached and unbleached eucalyptus fibers reinforcement on the mechanical, thermal and tribological properties of the composite were investigated for the first time. The results obtained suggested that both the two composites possesses good flexural properties, great thermal stability, and high coefficient of friction (COF) at 5 wt% fiber reinforcement. The degradation temperature at 5% weight loss (Td5) for PBEC and PUBEC stood at 368 and 342 ℃ respectively, with both having residual weight of more than 68%. Storage modulus of 5.25 and 5.10 GPa, and glass transition temperature (Tg) of 219 and 237°C were recorded for the BEFPC and UEFPC respectively. Findings from the study of flexural strength of the BEFPC and UEFPC conducted reveals that the flexural strengths were as high as 54.5 and 51.3 MPa respectively. Furthermore, interesting results from the study on the tribology of the composites shows that the coefficient of friction (COF) is in the range of 0.2–0.7, and wear rates were lower than 3.5×10− 7 cm3/Nm as required by Thailand Industrial Standard (TIS: 97-2014). Therefore, this study presents eucalyptus fiber-reinforced polybenzoxazine brake pad composites (EFPBC) as a potential friction materials for the automobile industry.
WITHDRAWN: Global glycoproteomic analysis reveals specific glycation and glycosylation events associated with cognitive decline in older adults with type 2 diabetes
Authors: Tickotsky Nili , Morgenstern David , Wolf-Levy Hila , Cooper Itzik , Uribarri Jaime , Unger Ron , Buchman Aron S. , Levin Yishai , Beeri Michal Schnaider 
Published: November 2022

Abstract
INTRODUCTION: Molecular mechanisms underlying the well-known association between Type 2 diabetes (T2D) and late-life cognitive impairment are unknown. Alterations in glyco post-translational modifications (PTM) of serum proteins reflect altered cellular physiology and are associated with T2D and impaired cognition.
This novel large-scale mass spectrometry based glycoproteomics study aimed to identify therapeutic PTM targets that may link T2D with poor cognition.
METHODS: We performed LC-MS/MS–based novel glycoproteomic profiling of sera samples from 23 cognitively normal older adults with T2D. At baseline all people had normal cognition, but during 36-months, 8 participants developed cognitive impairment while 15 maintained normal cognition
RESULTS: We identified and quantified a total of 1,866 unique glycoproteoforms (i.e., peptides with a post-transcription sugar modification) that matched 201 annotated proteins. Group differences were observed for 72 glycoproteoforms at baseline. At the time of cognitive testing three years later, there were group differences for 137 glycoproteoforms. Group differences were observed for 14 glycoproteoforms both at baseline and at 3-year follow-up.
DISCUSSION: Glycoproteoforms may contribute to cognitive impairment in T2D, may identify adults with T2D at risk for cognitive impairment and are high value therapeutic targets for new therapies to mitigate the negative cognitive effects of T2D in old age.
CXCL2 participates in NDRG3-mediated colorectal cancer metastasis
Authors: Wu Huo , Hu Lei 
Published: November 2022

Abstract
Purpose: In our previous work, we showed that NDRG3 facilitated colorectal cancer (CRC) metastasis, yet the molecular mechanism underlying NDRG3-mediated CRC metastasis has not been elucidated. Thus, we explored the role of chemokine (C-X-C motif) ligand 2 (CXCL2) in NDRG3-mediated CRC metastasis.
Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry were used to detected the expression of CXCL2 in CRC. CXCL2 was modified in RKO/shNDRG3 and SW1116/NDRG3 cells. Wound healing assay, invasion assay and xenograft model were then introduced to determine the role of CXCL2 in NDRG3-mediated CRC metastasis. Western blotting analysis was used to investigate the potential mechanism of CXCL2 in CRC metastasis.
Results: CXCL2 was highly expressed in CRC tissue. CXCL2 contributed to the invasion of CRC cells, and acted as a downstream target of NDRG3. Knockdown of CXCL2 abolished the NDRG3-mediated invasive capacity of SW1116 cells, whereas the overexpression of CXCL2 enhanced the invasiveness of the RKO/shNDRG3 cells. Similar results were obtained in the xenograft model. Western blot result showed that CXCL2 knockdown inhibits Src activation in SW1116/NDRG3 cells.
Conclusion: CXCL2 serves as an oncogene in CRC and participates in NDRG3-mediated CRC metastasis.
A proposal of a unit of length for space in SI and English unit systems helps to imagine the universe
Authors: TAT Mustafa Ertunç 
Published: November 2022

Abstract
In this study, I propose two new units of length to regulate dimension perception in space: "space-meter" for metric and "space-yard" for the English unit system. The first unit proposal is based on the equatorial diameter of the Moon, the closest and biggest celestial body that is observable to the naked eye. The second one is referenced to the speed of light in a vacuum.
The first proposal includes that one space-meter equals a hundred times the Moon's equatorial diameter of 3475 km, equal to 347,500.0 km in the metric system. In the English unit system, it is assumed that a quarter of a space-inch equals the Moon's diameter of 2159 mil; one space-yard becomes 310,896 mils. The second proposal offers that one “space-meter” equals 299,792.458 km, and one “space-yard” equals 186,282.3971 mils; the distances a light beam can travel in a second in space. The second proposal will preserve the consistency from kilometer to mile or vice versa in space while preserving the perception of dimension.
Impact of Reciprocal Cross and Heterosis Phenomenon on Various Tomato Traits
Authors: Chawsh Shilan , Arkwazee Haidar Anwar 
Published: November 2022

Abstract
Reciprocal hybrids are achieved by crossing parental genotypes in both directions, while heterosis happens when the F1s surpass their parental lines for a characteristic. Two different tomatoes (Solanum lycopersicum L.) cultivars were crossed reciprocally to study the impact of the reciprocal cross and heterosis phenomenon on numerous tomato characteristics. Fifty-two different traits were measured, including flower, fruit, leaf, shoot, roots, yield and yield components, and physiochemical traits. The results showed that various traits were significantly influenced by reciprocal crosses, such as plant mass, petal length, cone length, pistil length, fruit width, fruit length, single fruit weight, fruit flesh weight, seed and placenta weight, number of fruits locules, fruit calyx weight, number of days to flower, total sugar, ascorbic acid, anthocyanin, and total phenolic content. In addition, the results showed that several traits showed positive high parent heterosis, which are the sepal length, pistil length, flower fresh weight, flower dry weight, flower moisture content, number of clusters per plant, number of flowers per plant, number of flowers per cluster, number of fruits per cluster, fruits number per plant, total fruits weight per plant, leaf length, leaf fresh weight, leaf dry weight, number of branches per plant, plant height, plant mass, ascorbic acid, total carotene, and anthocyanin. These results will be significantly helpful for the future breeding program, especially for breeding for yield and yield components that showed strong heterosis for most of the traits.
Neuroprotection by arbutin against haloperidol-induced Tardive Dyskinesia in rats and reducing neurotoxicity in SHSY-5Y cells
Authors: Singh Gursewak , Upadhayay Shubham , Navik Umashanker , Kumar Puneet 
Published: November 2022

Abstract
Background: Schizophrenia is a psychological condition, and its primary treatment is an antipsychotic medication. However, long-term use of typical antipsychotics often causes irregular involuntary movements, targeting the orofacial region. Due to its complex pathophysiology, there is no appropriate cure for Tardive Dyskinesia (TD). Arbutin, is a natural polyphenol, which is well known for neuroprotection. Therefore, this study evaluated the neuroprotective potential of arbutin against haloperidol induced neurotoxicity and orofacial dysfunction in TD rats.
Methods & results: SH-SY5Y cells were treated with 1 mM concentration of haloperidol and arbutin (5, 10, 15, and 20 µM) for 48 hours, arbutin significantly reduced haloperidol-induced neurotoxicity. Other side, Wistar rats were treated with haloperidol (1 mg/kg/for 21 days) for induced TD like symptoms and treatment with arbutin (50 and 100 mg/kg i.p.) for 21 days show significant decrease in vacuous chewing movements, tongue protrusions, and facial jerking and improved locomotor activity and motor coordination in haloperidol-treated rats. Further, arbutin treatment causes a significant reduction in nitric oxide, MDA, TNF-α, IL-β, and increases SOD, GSH and catalase levels in the striatum region in contrast to haloperidol-treated rats.
Conclusion: In-vitro and In-vivo experimental outcomes suggest that arbutin has the neuroprotective potential that limit TD progression. Their results indicate that arbutin has anti-inflammatory and antioxidant properties that strengthen motor activity and could be explored for cellular and molecular pathways for possible use in the treatment of TD.
PAFormer: Pyramid Attention Transformer for Polyp Segmentation
Authors: Huang Zhiyong , Xie Fang , Qing WenCheng , Wang MengYao , Liu Man , Sun Daming 
Published: November 2022

Abstract
Adenomatous polyps are usually the most common tumor in clinical screening for colorectal cancer. Early detection and removal of these precursor lesions have been proved to be effective in preventing many cancers and reducing the mortality rate. Therefore, intelligent polyp detection is an urgent matter, which could assist clinicians to quickly identify detected polyps at an early stage. This paper proposes a polyp segmentation method based on sequential self-attentive networks with the features such as the color and texture of images and the relationship features between them. The color and texture features of the region image are extracted and fused with the original image. The resulting feature maps are serially input to the Transformer model to learn high-level spatial and attentional features. The loss of spatial information is reduced by multiscale local aggregation. By aggregating the models from a global perspective, the transformer model can further reduce the loss of context information caused by deep convolution. Controlled experiments between the PAFormer network and the mainstream polyp segmentation networks are conducted on five datasets, including ColonDB, ETIS, CVC-ColonDB, CVC-612 and Kvasir. The results show that the segmentation accuracy of PAFormer has great improvement on the datasets and PAFormer is superior to existing mainstream baseline networks.
Predictors of long-term healing for endorectal advancement flap for anorectal fistulas
Authors: Muharrem Oner , Abbas Maher Aref 
Published: November 2022

Abstract
Background
Anorectal fistulas are some of the commonest surgical proctologic disorders treated by surgeons. Despite the recent introduction of various sphincter preserving techniques, the search for the optimal operation continues. The purpose of this study was to determine the predictors of long-term healing for the endorectal advancement flap
Methods
A retrospective review of a single surgeon experience with the endorectal advancement flap for anorectal fistulas over an 18-year period. The impact of various patient and fistula related factors were analyzed for their impact on the primary endpoint of long-term fistula healing
Results
87 patients underwent endorectal advancement flap (Male/Female 42.5/57.5%). Median age was 41 years. Sixty-nine patients (79.3%) had anal fistula while 18 patients had rectal fistula (20.7%). An anterior based fistula was noted in 45 patients (51.7%). The most common etiology was cryptoglandular disease (87.4%). The median operative time was 75 minutes (range 36–250). Postoperative septic complications were noted in 4 patients (4.6%). Fistula healing was documented in 80 patients (93%). During a median follow-up of 4 months (range 1–38, 1 patient lost to follow-up), recurrence was noted in 8 patients (9.3%), yielding an overall long-term success rate of 83.7%. The long-term healing rate was higher in patients with fistulas from cryptoglandular etiology (86.6%) compared to fistulas from other etiologies (63.6%) [p = 0.027].
Conclusions
The endorectal advancement is associated with a high healing rate, a low postoperative septic complication rate, and infrequent risk for recurrence. Long-term healing without recurrence is achieved more frequently in patients with cryptoglandular etiology of the fistula compared to patients with non-cryptoglandular etiology.