bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bail-Out TEVAR through a Branch of Four-Arm Dacron Graft for Misdeployment of a Frozen Elephant Trunk Prosthesis
Authors: Kikuchi Yuta , Tsutsui Masahiro , Ushioda Ryohei , Shirasaka Tomonori , Kamiya Hiroyuki 
Published: May 2022

AbstractThe frozen elephant trunk (FET) is an effective method for making the distal anastomosis more proximal and facilitating aortic remodeling in acute aortic dissection. However, misdeployment of FET to the false lumen has been reported in several cases. Such cases are usually treated with bail-out thoracic endovascular aortic repair (TEVAR) through the femoral artery or additional FET under direct vision to redirect the blood flow to the true lumen. We encountered a case of misdeployment of FET into the false lumen during open aortic surgery for the treatment of Stanford type A acute aortic dissection. After reconstruction of the aorta and all arch vessels, we performed antegrade bail-out TEVAR through a side branch of the four-arm Dacron graft as main access using a pull-through technique through the right femoral artery, which was perfused from the true lumen. This technique, which uses a Dacron graft branch for stent graft access, enabled us to confirm the true lumen because the distal anastomotic site was definitely the true lumen, and we were also able to avoid access difficulties at the iliac artery.
A Multicountry Analysis of Prevalence and Mortality among Neonates and Children with Bladder Exstrophy
Authors: Kancherla Vijaya , Tandaki Lucita , Sundar Manasvi , Lux Anke , Bakker Marian K , Bergman Jorieke EH , Bermejo-Sánchez Eva , Canfield Mark A , Feldkamp Marcia L , Groisman Boris , Hurtado-Villa Paula , Källén Karin , Landau Danielle , Lelong Nathalie , Lopez-Camelo Jorge , Mastroiacovo Pierpaolo , Morgan Margery , Mutchinick Osvaldo M , Nance Amy E , Nembhard Wendy N , Pierini Anna , Šípek Antonin , Stallings Erin B , Szabova Elena , Wertelecki Wladimir , Zarante Ignacio , Rissmann Anke 
Published: May 2022

Objective Bladder exstrophy (BE) is a rare but severe birth defect affecting the lower abdominal wall and genitourinary system. The objective of the study is to examine the total prevalence, trends in prevalence, and age-specific mortality among individuals with BE.
Study Design We conducted a retrospective cohort study. Data were analyzed from 20 birth defects surveillance programs, members of the International Clearinghouse for Birth Defects Surveillance and Research in 16 countries. Live births, stillbirths, and elective terminations of pregnancy for fetal anomaly (ETOPFA) diagnosed with BE from 1974 to 2014. Pooled and program-specific prevalence of BE per 100,000 total births was calculated. The 95% confidence intervals (CI) for prevalence were estimated using Poisson approximation of binomial distribution. Time trends in prevalence of BE from 2000 to 2014 were examined using Poisson regression. Proportion of deaths among BE cases was calculated on the day of birth, day 2 to 6, day 7 to 27, day 28 to 364, 1 to 4 years, and ≥5 years. Mortality analysis was stratified by isolated, multiple, and syndromic case status.
Results The pooled total prevalence of BE was 2.58 per 100,000 total births (95% CI = 2.40, 2.78) for study years 1974 to 2014. Prevalence varied over time with a decreasing trend from 2000 to 2014. The first-week mortality proportion was 3.5, 17.3, and 14.6% among isolated, multiple, and syndromic BE cases, respectively. The majority of first-week mortality occurred on the first day of life among isolated, multiple, and syndromic BE cases. The proportion of first-week deaths was higher among cases reported from programs in Latin America where ETOPFA services were not available.
Conclusion Prevalence of BE varied by program and showed a decreasing trend from 2000 to –2014. Mortality is a concern among multiple and syndromic cases, and a high proportion of deaths among cases occurred during the first week of life.
Key Points
Therapeutic Role of Astaxanthin and Resveratrol in an Experimental Rat Model of Supraceliac Aortic Ischemia-Reperfusion
Authors: Dilli Dilek , Taşoğlu İrfan , Sarı Eyüp , Akduman Hasan , Yumuşak Nihat , Tümer Naim Boran , Salar Salih 
Published: May 2022

Objective The aim of the study is to investigate the therapeutic effects of astaxanthin (AST) and resveratrol (RVT) on multiorgan damage in an animal model of the supraceliac aortic ischemia-reperfusion (I/R).
Methods In this study, 28 rats (n = 7/group), 200 to 250 g in weight, were randomized to four groups (1: Sham, 2: Control + I/R, 3: AST + I/R, and 4: RVT + I/R). Following the abdominal incision, aortic dissection was performed in the sham group without injury. Other groups underwent I/R injury via supraceliac aortic clamping (20 minutes) and reperfusion. The rats were administered olive oil (3 mL/kg) orally for 2 weeks before and 1 week after the laparotomy. Additionally, oral AST (10 mg/kg) or RVT (50 mg/kg) was given to the study groups. All rats were sacrificed on the 3rd week of the experiment after blood samples were taken for analysis. Multiple rat tissues were removed.
Results We found that RVT increased total antioxidant status (TAS) and superoxide dismutase (SOD) levels, and decreased total oxidant status (TOS), oxidative stress index (OSI), myeloperoxidase (MPO), and malondialdehyde (MDA) levels, while AST increased the levels of TAS, decreased TNF-α, MDA, TOS, and OSI (p <0.05). Pathological investigations of the rat tissues revealed that both AST and RVT ameliorated tissue damage and apoptosis.
Conclusion Our study suggests that AST and RVT might show therapeutic effects against oxidative tissue damage and apoptosis in an animal model of aortic I/R. Further studies are required.
Key Points
Preservation of Peri-Implant Papilla: A Narrative Review
Authors: Venkatesh Nandita , Shetty Manoj , John Nivya 
Published: May 2022

AbstractBeside osseointegration and restoration of function, the patient's subjective satisfaction with the esthetic result is a touchstone of the success of implant therapy. The long-term maintenance and reconstruction of papilla-like soft tissue between two adjacent implants in the esthetic zone which is esthetically satisfactory is generally regarded as a challenge. The road to success is much more complicated with implants, because of biologic and anatomical limitations of peri-implant tissues. Numerous techniques have been proposed to manage the hard and soft tissues in an attempt to achieve ideal esthetic results which includes surgical and nonsurgical techniques. The goal of reconstructive procedures is to provide peri-implant bone that supports and maintains gingival contours. An interdisciplinary approach has an obvious advantage of long-term preservation of a healthy peri-implant tissue which is of key importance in ensuring acceptable function and subjective satisfaction of esthetics of dental implants. A detailed literature search was performed in English language from 1986 to 2012, which included review articles, original research, as well as case reports. The search was performed in National Library of Medicine's PubMed database, Google Search, and Science Direct. A manual search of hard copies of available journal was also performed using interdental papilla, peri-implant papilla, esthetics, and dental implant as key words, in an attempt to gain insight into the limitations of papilla preservation, the factors which may potentially affect the maintenance and reconstruction of inter-implant papilla, and the contemporary methods to augment it.
The Impact of Community Empowerment Programs on Oral Health Education for Knowledge Improvement in the Elderly
Authors: Ayuningtyas Nurina Febriyanti , Parmadiati Adiastuti Endah , Mahdani Fatma Yasmin , Marsetyo Riyan Iman , Femilian Afryla , Siregar Maslah 
Published: May 2022

Abstract
Objective This study aims to assess whether community empowerment as a health promotion program can improve the knowledge of the elderly and develop self-awareness about their oral health. The elderly population has increased in number and needs special attention, especially regarding the improvement of hygiene and health. Community empowerment is a type of health promotion program that can take the form of counseling and providing knowledge about oral health to the elderly.
Materials and Methods Participants are elderly aged 60 years or older. Counseling was done by oral medicine specialists and residents to provide knowledge about oral health problems. Assessment of knowledge improvement was done using pretest and posttest in a written questionnaire.
Statistical Analysis The Shapiro–Wilk test followed by the Wilcoxon test was used to compare the difference before and after counseling.
Results From a total of 38 elderly included in this study, 29 (76.32%) showed an improved score in posttest compared with pretest. Statistical analysis showed a significant difference between pretest and posttest scores of study participants (p < 0.005).
Conclusion Counseling in empowerment programs can help the elderly improve their knowledge about oral health, so that improvements can be expected to be followed by the development of self-awareness in the future.
Amount of Proteinuria and Duration of Expectant Management in Severe Preeclampsia
Authors: Cozzi Gabriella D. , Battarbee Ashley N. , Sanjanwala Aalok R. , Casey Brian M. , Subramaniam Akila 
Published: May 2022

Objective The aim of the study is to evaluate the association between the amount of proteinuria at the time of diagnosis of preeclampsia with severe features (severe preeclampsia [SPE]) and duration of expectant management (EM) and other perinatal outcomes.
Study Design This is a retrospective cohort study of patients with SPE delivering live, non-anomalous singletons at 230/7 to 342/7 weeks' estimated gestational age (EGA) at a single tertiary center 2016 to 2018. Patients with proteinuria assessment (24-hour total urine protein or urine protein-to-creatinine ratio extrapolation) within 3 days of SPE diagnosis were included. Patients delivered for an indication other than SPE were excluded. Patients were categorized by amount of proteinuria (mg): none (≤300), mild (301–1,000), moderate (1,001–3,000), and massive (≥3,001). The primary outcome was the proportion of potential EM time achieved (%EM), i.e., days of EM divided by days from SPE diagnosis to 34 weeks. Secondary outcomes included delivery EGA, days of EM, and perinatal outcomes. Bivariable and multivariable analyses compared outcomes across groups.
Results Of 295 patients included, 21% had no proteinuria, 33% mild, 19% moderate, and 27% massive. Groups differed by EGA at diagnosis, age, parity, chronic hypertension, and renal disease. %EM was not significantly different between groups (adjusted β coefficient 4.1 [95% CI −5.3, 13.5] for mild proteinuria vs. none, −4.1 [95% CI −14.9, 6.6] for moderate proteinuria vs. none, and −5.6 [95% CI −16.0, 4.7] for massive proteinuria vs. none). Increasing proteinuria was associated with earlier delivery EGA but only days of EM in the mild versus no proteinuria groups. There was no significant association between proteinuria and maternal composite morbidity, but patients with mild and massive proteinuria had higher odds of neonatal composite morbidities compared with no proteinuria.
Conclusion Among patients with SPE, proteinuria level was not consistently associated with duration of EM. However, patients with the greatest amounts of proteinuria may have worse neonatal and selected maternal outcomes.
Key Points
Gender Determination by Measuring Maxillary Sinus Volume Using Computed Tomography
Authors: Tiwari Sashisaroj Tarkeshwar , U. Shrikrishna , MM Jaseemudheen 
Published: May 2022

Abstract
Rationale and Objectives Skeleton analysis based on age and gender is of great importance since it is an initial step in personal identification and can be used to rebuild biological profiles and narrow down diagnosis toward correct possibilities of any unknown skeletons. Different dimensions of the maxillary sinus (MS) can be used to differentiate between gender. This study aims to evaluate and compare the dimensions and volume of MS among age and genders.
Materials and Methods Ninety patients (male 49, female 41) were studied. Different dimensions of MS, like anteroposterior (AP), superioinferior (SI), mediolateral (ML) diameter, volume of MS, and the distance between two MS were measured on computed tomography (CT) paranasal sinus images using an inbuilt electronic caliper on Digital Imaging and Communications in Medicine viewer software.
Statistical Analysis Independent t-test and analysis of variance were used for data analysis in genders and age groups. Paired t-test was used for comparison of right and left MS.
Results The dimensions and volume of MS were higher in males than females. Dimensions such as AP, SI diameter (p < 0.005), and volume of MS (p < 0.001) were significantly different in genders. The ML diameter and the distance between two MS were statistically insignificant in genders. No significant difference between MS dimensions and volume was noted in different age groups, but age group 3 (41–55 years) showed higher mean values for all the measurements. A consistency was noted in the measurements in both two-dimensional (2D) and three-dimensional (3D) images.
Conclusion MS dimensions are greater in males compared with females. The different dimensions and volumes of the MS using 2D or 3D CT scan images can be used along with other methods for gender determination in forensic anthropology.
Can Minimally Invasive Multivessel Coronary Revascularization Be a Routine Approach?
Authors: Kyaruzi Mugisha , Gülmez Harun , Demirsoy Ergun 
Published: May 2022

Abstract
Background Advancement in the field of cardiovascular surgery has emerged with various minimally invasive approaches for the treatment of multivessel coronary disease to improve outcomes and minimize the burden associated with conventional cardiac surgery. This study describes our routine technical approach and clinical experience of minimally invasive coronary artery bypass via left anterior minithoracotomy for the treatment of patients with multivessel coronary lesions.
Methods Our experience includes 100 consecutive patients who were operated between July 2020 and April 2021. The left internal thoracic artery was harvested in all patients. Radial arterial grafts and saphenous vein grafts were harvested endoscopically. Patients were operated either under cardiopulmonary bypass (CPB) with blood cardioplegia through left anterior minithoracotomy of 5 to 7 cm or off-pump via left anterolateral minithoracotomy.
Results We had single mortality (1%), no early postoperative myocardial infarction was observed. None of our patients was converted to sternotomy (0%). The mean number of bypass was 3.1 ± 0.8, the mean cross-clamping time was 78.1 ± 20.6 minutes, the mean CPB time was 153.2 ± 37.5 minutes, the average intubation time was 6.33 ± 11.29 hours, the mean intensive care unit stay was 1.62 ± 1.78 days, the mean hospital stay was 4.98 ± 3.01 days, the average total operation time was 4.20 ± 0.92 hours, and the average pleural drain was 393.8 ± 169.7 mL.
Conclusion Minimally invasive coronary artery bypass grafting via left anterior minithoracotomy can be routinely performed with safety and it is feasible, reproducible with a short learning curve. Further multicenter studies are needed for the standardization of our technique.
Responses in growth, yield and cob protein content of baby corn (
Authors: Thi Loan K. , Yunusa Isa A. M. , Rab M. A. , Zerihun Ayalsew , Nguyen Hoa M. 
Published: May 2022

Cropping of acid sulfate soils requires effective treatment of their inherently low pH. We evaluated the efficacy of applications of two levels of lime (0 or 2 Mg/ha), two levels of organic fertiliser (0 or 5 Mg/ha), and three levels of biochar (0, 10 or 30 Mg/ha) in a factorial design for ameliorating acidity in an acid sulfate soil, and measured the subsequent growth and yield of baby corn (Zea mays L.). Lime increased soil pH(H2O) from 3.75 to 4.12, salinity from 1.72 to 1.95 dS/m, and cob yield by 30%. None of the amendments significantly altered total organic carbon or total nitrogen concentrations in the soil. Biochar additions increased cob yields by an average of 28% on both unlimed and limed soil. Addition of organic fertiliser increased cob yield by 45% on unlimed soil but had no significant effect on yields on limed soil. The yields obtained with liming were similar to the highest yields achieved with biochar or organic fertiliser applied either separately or in combinations. Overall, cob yields were increased by 19% with addition of organic fertiliser. The yield increseas from additions of biochar or organic fertiliser were associated with improvements in nutrient supply. However, the increases in cob yield were associated with reduced cob protein, probably resulting from poor availability of nitrogen late in the season. We conclude that biochar and organic fertiliser applied in relatively large quantities can be viable treatments for cropping acid sulfate soils.
The connection between COVID-19 vaccine abundance, vaccination coverage, and public trust in government across the globe
Authors: Monfared Ida G. 
Published: May 2022

AbstractThis study investigates that how the number of COVID-19 vaccines secured correlates with the vaccination coverage (full and booster) depending on whether there is trust in national government or not across 47 countries. The data are based on global figures as of Nov. 2021 and Feb. 2022 while measures for confidence in government is according to Gallup World Poll, Oct. 2021. The model includes an interaction term of the two key variables, also controls for a range of socio-economic factors and country specific variables. The results indicate a non-linear and mixed relationship between the number secured, the public trust, and the vaccination rate. In Feb. 2022, with confidence in government, securing number of vaccines to cover 200% of the population (or more) increased the full vaccination rate by 12.26% (95% CI: 11.70 - 12.81); where number secured was 300% (or more), the coverage increased by 7.46% (95% CI: 6.95 - 7.97). Under similar scenarios, rate of booster shots increased by 13.16% (95% CI: 12.62 - 13.70; p < 0.01) and 14.36% (95% CI: 13.86 - 14.85; p < 0.01), respectively. Where the number secured fell below 200%, confidence in government had a revers relationship with the rate of full vaccination (-2.65; 95% CI: -3.32 - -1.99), yet positive with the rate of booster shots (1.65; 95% CI: 1.18 - 2.12). These results indicate that better success can be achieved by a combination of factors including securing sufficient number of vaccines and also ensuring the public trust. Vaccine abundance, however, cannot be translated into greater success in vaccination coverage. This study highlights the importance of efficiency in acquiring vaccine resources and need for improvement in public belief in immunization programmes rather than stock piling.
Photosystem genes in chloroplast and their interacting partners: A case for molecular adaptation to carnivory inNepenthaceae
Authors: Krishnan Neeraja M , Panda Binay 
Published: May 2022

ABSTRACTMolecular adaptations are prevalent in carnivorous plants in response to habitat and environmental stress. We used the chloroplast genome and characterized the specific adaptations in the photosystem genes and their interacting partners inNepenthes khasiana, a carnivorous pitcher plant. When compared with the carnivorous and non-carnivorous groups across Caryophyllales, Lamiales, Poales, Ericales, and Oxalidales, we foundNepenthes-specific changes in psaA, psaB, psaC and psaH. Of these, only a single amino acid change each, G147 in the protein psaA and R40 in the protein ndhD, impacted the three-dimensional structural conformation of the corresponding proteins. Modeling the interaction between the psaA and the ndhD proteins identified group-specific changes between the models betweenNepentheceaeversus others. The least distance between the structure-impacting residues of psaA and ndhD was 25.9 Å forNepenthesand 19.4 Å for non-Nepenthesmodels. Given that the chloroplast ndh and photosystem I subunits form a large super-complex with the light-harvesting carrier proteins from the nucleus to mediate cyclic electron transport, our observations may indicate specific adaptations in the cyclic electron transport arm of the photosynthetic machinery in theNepenthesspecies.
Long-range alpha-synchronisation as control signal for BCI: A feasibility study
Authors: Esparza-Iaizzo Martín , Vigué-Guix Irene , Ruzzoli Manuela , Torralba Mireia , Soto-Faraco Salvador 
Published: May 2022

ABSTRACTShifts in spatial attention are associated with variations in alpha-band (α, 8–14 Hz) activity, specifically in inter-hemispheric imbalance. The underlying mechanism is attributed to local α-synchronisation, which regulates local inhibition of neural excitability, and fronto-parietal synchronisation reflecting long-range communication. The direction-specific nature of this neural correlate brings forward its potential as a control signal in brain-computer interfaces (BCI). In the present study, we explored whether long-range α-synchronisation presents lateralised patterns dependent on voluntary attention orienting and whether these neural patterns can be picked up at a single-trial level to provide a control signal for active BCI. We collected electroencephalography (EEG) data from a cohort of healthy adults (n = 10) while performing a covert visuospatial attention (CVSA) task. The data shows a lateralised pattern of α-band phase coupling between frontal and parieto-occipital regions after target presentation, replicating previous findings. This pattern, however, was not evident during the cue-to-target orienting interval, the ideal time window for BCI. Furthermore, decoding the direction of attention trial-by-trial from cue-locked synchronisation with support vector machines (SVM) was at chance-level. The present findings suggest EEG may not be capable of detecting long-range α-synchronisation in attentional orienting on a single-trial basis and, thus, highlight the limitations of this metric as a reliable signal for BCI control.SIGNIFICANCE STATEMENTCognitive neuroscience advances should ideally have a real-world impact, with an obvious avenue for transference being BCI applications. The hope is to faithfully translate user-generated brain endogenous states into control signals to actuate devices. A paramount challenge for transfer is to move from group-level, multi-trial average approaches to single-trial level. Here, we evaluated the feasibility of single-trial estimation of phase synchrony across distant brain regions. Although many studies link attention to long-range synchrony modulation, this metric has never been used to control BCI. We present a first attempt of a synchrony-based BCI that, albeit unsuccessful, should help break new ground to map endogenous attention shifts to real-time control of brain-computer actuated systems.