bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authorship Equity and Gender Representation in Global Oncology Publications
Authors: Hornstein Paula , Tuyishime Hubert , Mutebi Miriam , Lasebikan Nwamaka , Rubagumya Fidel , Fadelu Temidayo 
Published: January 2022

PURPOSE Authorship gender disparities persist across academic disciplines, including oncology. However, little is known about global variation in authorship gender distribution. METHODS This retrospective cross-sectional study describes the distribution of author gender as determined from the first name across variables such as authorship position (first, middle, and last), country region, and country income level. The 608 articles with 5,302 authors included in this analysis were published in the Journal of Clinical Oncology Global Oncology, from its inception in October 2015 through March 2020. Primary outcome measure was author gender on the basis of first name probabilities assessed by genderize.io. World Bank classification was used to categorize the country region and income level. Odds ratios were used to describe associations between female last authorship and representation in other authorship positions. RESULTS Although female authors were in the minority across all authorship positions, they were more under-represented in the last author position with 190 (32.1%) female, compared with 252 (41.4%) female first authors and 1,564 (38.1%) female middle authors. Female authors were most under-represented among authors from low-income countries, where they made up 21.6% of first authors and 9.1% of last authors. Of all the regions, sub-Saharan Africa and South Asia had the lowest percentage of female authors. Compared with articles with male last authors, those with female last authors had odds ratios (95% CI) of 2.2 (1.6 to 3.2) of having female first authors and 1.4 (0.9 to 2.1) of having 50% or more female middle authors. CONCLUSION There are wide regional variations in author gender distribution in global oncology. Female authors remain markedly under-represented, especially in lower-income countries, sub-Saharan Africa, and South Asia. Future interventions should be tailored to mitigate these disparities.
Indication-Specific Generic Uptake of Imatinib Demonstrates the Impact of Skinny Labeling
Authors: Walsh Bryan S. , Kesselheim Aaron S. , Sarpatwari Ameet , Rome Benjamin N. 
Published: January 2022

PURPOSE Generic competition can be delayed if brand-name manufacturers obtain additional patents on supplemental uses. The US Food and Drug Administration allows generic drug manufacturers to market versions with skinny labels that exclude patent-protected indications. This study assessed whether use of generic versions of imatinib varied between indications included and excluded from the skinny labels. METHODS In this cross-sectional study, we identified adult patients covered by commercial insurance or Medicare Advantage plans who initiated imatinib from February 2016 (first generic availability) to September 2020. Generic versions were introduced with skinny labels that included indications covering treatment of chronic myelogenous leukemia (CML) but excluded treatment of gastrointestinal stromal tumors (GISTs) because of remaining patent protections. Logistic regression was used to determine whether use of generic versus brand-name imatinib differed between patients with a diagnosis of CML or GIST, adjusting for demographics, insurance type, prior use of brand-name drugs, and calendar month. RESULTS Among 2,000 initiators, 934 (47%) had CML and 686 (34%) had GIST. Within 3 years after generics entered the market, more than 90% of initiators in both groups used generic imatinib. Initiation of generic imatinib was slightly lower among patients with GIST than among patients with CML (85% v 88%; adjusted odds ratio 0.56; 95% CI, 0.39 to 0.80; P ≤ .001). CONCLUSION Generic versions of imatinib were dispensed frequently for indications both included (CML) and excluded (GIST) from the skinny labeling, although patients with GIST were slightly less likely to receive a generic version. The skinny labeling pathway allowed generics to enter the market before patent protection for treating patients with GIST expired, facilitating lower drug prices.
Synthesis of C3-Symmetric Macrocyclic Triimines from Monomers Having Boc-protected Amine and Formyl Group
Authors: Moriya Yu , Yamanaka Masahiro , Mori Keiji 
Published: January 2022

Abstract
A concise access to C3-symmetric macrocyclic triimines was developed. When biphenyls having a formyl group on one phenyl group and an NHBoc group on the other phenyl group were treated with an excess amount of concentrated HCl in 1,4-dioxane, the detachment of the Boc group followed by a trimerization reaction via imine formation proceeded smoothly to afford C3-symmetric imine-linked macrocycles in good chemical yields.
Mental illness due to homelessness: a qualitative case study in Melaka, Malaysia
Authors: Mohd Rom Noor Ashikin , Yaakob Mohamad Lusfi , Md. Hassan Nurbani , Ramli Hani Suhaila 
Published: January 2022

Background: Extreme poverty can result in people barely surviving with poor living standards to the extent of living on the streets, often in fear. With limited access to healthcare services and a clean environment, they are more vulnerable to life adversities. Highly stressful living conditions like these can cause mental illnesses such as depressive disorders, anxiety disorders, psychological distress, and others. Purpose: This research aimed to investigate factors that led to the development of mental illness among homeless people under extreme poverty. Design/methodology/approach: This was a qualitative case study that involved a face-to-face interview with a key informant at the Pertubuhan Kebajikan Villa Harapan Melaka (Villa Harapan). Villa Harapan is a licensed caretaker centre established by the Department of Welfare, Melaka that provides shelter to homeless people with mental illness. Findings: Homeless people suffered from mental disturbances due to loss of jobs, lack of income, broken families, separation from their children, and other vulnerabilities. They are not getting appropriate care and attention for their problem and sickness. Non-supportive family, extreme poverty, and chronic stress were the main factors that led to mental illness among Villa Harapan residents. Research limitations: The study focused on the mental illness of dispossessed people who were brought to Villa Harapan by the Welfare Department. Originality/value: This was an empirical case study on mental illness among homeless people at a care centre known as Villa Harapan.
Foundation in Law students’ reading awareness of the case law genre
Authors: Abdullah Suhaila , Kaur Bhar Sareen 
Published: January 2022

Background: A text of different genre might pose a different problem to students and different genre requires different approach in understanding and comprehending it. Developing the expertise in reading legal texts at an early stage of learning will be very beneficial to the students of law. This study examines the level of pre-university/foundation in law students’ awareness for the case law genre, and the aim of this study is to investigate the extent of awareness of the case law genre among the foundation in law students. Methods: Five students who were pursuing their study in the foundation/pre-university level were selected as the subjects in this study. Qualitative data were obtained through the think-aloud procedure and questionnaire which was administered after the think-aloud procedure. The transcription of each student’s verbal reports was scrutinised for evidence of genre awareness while the answers given in the questionnaire were used to support the findings of the study. Genre analysis of 4-Move structure was used to identify the students’ level of awareness. Results: The findings indicate that the students were aware of the case law genre. However, they displayed a mixed-level of awareness. Conclusion: It is hoped that this study can provide some insights into the reading behaviour of law students especially when reading case law. Knowing and understanding the case law structure is integral for law students, and analysing students understanding of reading case law can help both the students and English for Academic Purposes (EAP) educators.
Effect of whitening toothpaste on surface roughness and microhardness of human teeth: a systematic review and meta-analysis
Authors: Jamwal Navodita , Rao Ashwini , Shenoy Ramya , Pai Mithun , KS Aparna , BR Avinash 
Published: January 2022

Background: Whitening toothpastes exert a whitening effect on teeth through higher surface cleaning effectiveness resulting from the abrasive properties of the paste or specific chemical components. This systematic review and meta-analysis was conceptualized to examine the relationship between whitening toothpastes and surface roughness as well as microhardness of human teeth and to clarify the evidence base available around this relationship by conducting a systematic review and meta-analysis of studies in this topic area, looking at in vitro randomized control trials. Methods: Criteria for including studies in the review were done based on population, intervention, comparison, outcomes and study and studies were identified from electronic databases. Covidence® was used for data screening and data extraction. The CONSORT tool was used for checking relevant content and methodology used in each of the papers reviewed. Systematic review was done followed by meta-analysis, using Review Manager. Results: A total of 125 articles were obtained on key word search. After duplicate removal and title screening, 17 articles were eligible for full text review. Finally, 7 studies were included for systematic review and meta-analysis was conducted on 4 studies. The forest plot for surface roughness showed that that the meta-analytic effect was statistically significant with surface roughness value being higher in the intervention group. The forest plot for microhardness showed that the meta-analytic effect was statistically significant with the microhardness value being lesser in the intervention group. Conclusions: Although whitening toothpastes typically can lighten tooth color by about one or two shades, there is some evidence to show that these toothpastes also affect the mineral content of teeth by increasing surface roughness and reducing microhardness. More evidence and further research are needed to identify the type of whitening agent which will whiten the tooth effectively while maintaining the integrity of the tooth structure.
Dynamic participation in local energy communities with peer-to-peer trading
Authors: Perger Theresia , Auer Hans 
Published: January 2022

Background: Energy communities and local electricity markets (e.g., as peer-to-peer trading) are on the rise due to increasingly decentralized electricity generation and favorable adjustment of the legal framework in many European countries. Methods: This work applies a bi-level optimization model for dynamic participation in peer-to-peer electricity trading to determine the optimal parameters of new participants who want to join an energy community, based on the preferences of the members of the original community (e.g., environmental, economic, or mixed preference). The upper-level problem chooses optimal parameters by minimizing an objective function that includes the prosumers' cost-saving and emission-saving preferences, while the lower level problem maximizes community welfare by optimally allocating locally generated photovoltaic (PV) electricity between members according to their willingness-to-pay. The bi-level problem is solved by transforming the lower level problem by its corresponding Karush-Kuhn-Tucker (KKT) conditions. Results: The results demonstrate that environment-oriented prosumers opt for a new prosumer with high PV capacities installed and low electricity demand, whereas profit-oriented prosumers prefer a new member with high demand but no PV system capacity, presenting a new source of income. Sensitivity analyses indicate that new prosumers' willingness-to-pay has an important influence when the community must decide between two new members. Conclusions: The added value of this work is that the proposed method can be seen as a basis for a selection process between a large number of potential new community members. Most important future work will include optimization of energy communities over the horizon several years.
Weighted Scoring Rules and Convex Risk Measures
Authors: Smith Zachary J. , Bickel J. Eric 
Published: January 2022

In Weighted Scoring Rules and Convex Risk Measures, Dr. Zachary J. Smith and Prof. J. Eric Bickel (both at the University of Texas at Austin) present a general connection between weighted proper scoring rules and investment decisions involving the minimization of a convex risk measure. Weighted scoring rules are quantitative tools for evaluating the accuracy of probabilistic forecasts relative to a baseline distribution. In their paper, the authors demonstrate that the relationship between convex risk measures and weighted scoring rules relates closely with previous economic characterizations of weighted scores based on expected utility maximization. As illustrative examples, the authors study two families of weighted scoring rules based on phi-divergences (generalizations of the Weighted Power and Weighted Pseudospherical Scoring rules) along with their corresponding risk measures. The paper will be of particular interest to the decision analysis and mathematical finance communities as well as those interested in the elicitation and evaluation of subjective probabilistic forecasts.
Olive oil intake and cancer risk: A systematic review and meta-analysis
Authors: Markellos Christos , Ourailidou Maria-Eleni , Gavriatopoulou Maria , Halvatsiotis Panagiotis , Sergentanis Theodoros N. , Psaltopoulou Theodora 
Published: January 2022

BackgroundResearch evidence has established the beneficial effects of diet in cancer prevention; various epidemiological studies have suggested that olive oil component could play a role in decreasing cancer risk. This systematic review and meta-analysis aims to investigate the association between olive oil consumption, cancer risk and prognosis.MethodsA systematic search was conducted in PubMed, EMBASE and Google Scholar databases (end-of-search: May 10, 2020). Pooled relative risk (RR) and 95% confidence intervals (95% CIs) were estimated with random-effects (DerSimonian-Laird) models. Subgroup analyses, sensitivity analyses and meta-regression analysis were also performed.Results45 studies were included in the meta-analysis; 37 were case-control (17,369 cases and 28,294 controls) and 8 were cohort studies (12,461 incident cases in a total cohort of 929,771 subjects). Highest olive oil consumption was associated with 31% lower likelihood of any cancer (pooled RR = 0.69, 95%CI: 0.62–0.77), breast (RR = 0.67, 95%CI: 0.52–0.86), gastrointestinal (RR = 0.77, 95%CI: 0.66–0.89), upper aerodigestive (RR = 0.74, 95%CI: 0.60–0.91) and urinary tract cancer (RR = 0.46, 95%CI: 0.29–0.72). Significant overall effects spanned both Mediterranean and non-Mediterranean participants, studies presenting a multivariate and a univariate analysis and all subgroups by study quality.ConclusionsOlive oil consumption seems to exert beneficial actions in terms of cancer prevention. Additional prospective cohort studies on various cancer types and survivors, as well as large randomized trials, seem desirable.
Researchers’ View on R&D Organizational Change Using the Grief Cycle
Authors: Romadona Mia Rahma , Setiawan Sigit 
Published: January 2022

<p>When change becomes a need, research and development organizations must likewise be adaptable to new challenges. The necessary changes will provide difficulties for management to manage human resource development. Failure, stagnation, or success is the eventual consequence of every organizational reform. Organizational changes are effective or unsuccessful based on the implementation strategies used, emphasizing the significance of human development managerial skills, leadership communication, and organizational interpersonal communication. This study aims to present an empirical study of changes occurring in research and development companies using grief cycle analysis. This research utilizes a variety of aspects and documents from prior studies to analyze the collective grief cycle phenomena associated with organizational changes in the R&amp;D sector. The empirical description of the grieving cycle analysis demonstrates that the outcome of the grief cycle process indicates that the organization is not prepared to undertake changes, resulting in the crisis of certain workers. An empirical account of grieving cycle analysis reveals that time and the process of habituation play a significant influence in organizational members acceptance of changes in research and development organizations. Leadership communication and organizational interpersonal communication are critical in influencing organizational members' comprehension and acceptance of organizational goals and change processes..</p><p> </p>Keywords: grief cycle, organizational change R&amp;D, acceptance, HR management, leadership communication, organizational interpersonal communication
Gestão da Atenção Primária: uma proposta de avaliação de impacto da APS em duas cidades do Nordeste do Brasil
Authors: Moita Galba Freire 
Published: January 2022

Esse estudo apresenta uma proposta de avaliação de impacto na APS a partir da análise contextual da atenção primaria em duas grandes cidades do Ceará, visto que Fortaleza (gestão incremental por OSs) e Sobral (Gestão Pública) representam ambientes privilegiados para a aplicação de modelos avaliativos visando mensurar o impacto, a eficiência, a efetividade e a resolutividade aplicáveis em diferentes contextos da APS do Brasil.
Palavras-chave: Direção e Governança do Setor de Saúde, Avaliação de Processos e Resultados (cuidado de saúde), Avaliação em Saúde, Qualidade, Acesso e Avaliação da Assistência à Saúde, Avaliação do Impacto na Saúde.

Abstract
This study presents a proposal for impact assessment on PHC from the contextual analysis of primary care in two large cities in Ceará, since Fortaleza (incremental management by OSs - non-profit health organization) and Sobral (Public Management) represent privileged environments for the application of evaluation models aiming to measure the impact, efficiency, effectiveness and resoluteness applicable in different contexts of PHC in Brazil.

Keywords: Health Sector Stewardship and Governance. Process and Results Evaluation (health care). Health Assessment. Quality, Access and Evaluation of Health Care. Health Impact Assessment.
Intervenções Psicológicas na Iminência do Suicídio à Luz da Gestalt-Terapia / Psychological Interventions in the Imminence of Suicide in the light of Gestalt Therapy
Authors: Souza Eribetânia Maria Carvalho , Belmino Marcus Cézar De Borba 
Published: January 2022

Resumo: A proposta deste artigo é discutir os processos de intervenção da Gestalt-terapia em situação de iminente suicídio, dentro do processo de psicoterapia. Para tal, foi realizada uma pesquisa qualitativa através de uma revisão bibliográfica, utilizando-se da análise de conteúdo do material encontrado. Desse modo, ressalta-se que a pesquisa percorre um caminho histórico do fenômeno suicida e da abordagem gestáltica, para assim, entender e discutir sobre possíveis intervenções frente a iminência do ato suicida. Ademais, pretende-se refletir sobre o papel do Gestalt-terapeuta, frente a esta demanda e como é visto a pessoa que atenta contra a sua própria vida. Posto isso, salienta-se o papel do Gestalt-terapeuta com o manejo as situações de suicídio, possibilitando uma abertura para ouvir o desejo de morte, atuando de modo a realizar desvios éticos, políticos e antropológicos, bem como prestando acolhimento ao sofrimento dos consulentes para a criação conjunta de novas possibilidades de futuro para além da morte. Logo, destaca-se a importância do compromisso ético-político do profissional psicólogo perante o sofrimento do sujeito frente ao suicídio. Palavras-chave: Gestalt-Terapia; Suicídio; Clínica psicológica. Abstract: The purpose of this article is to discuss the intervention processes of Gestalt therapy in situations of imminent suicide, within the psychotherapy process. To this end, a qualitative research was carried out through a literature review, using the content analysis of the material found. Thus, it is noteworthy that the research follows a historical path of the suicidal phenomenon and the gestalt approach, in order to understand and discuss possible interventions in view of the imminence of the suicidal act. Furthermore, it is intended to reflect on the role of the Gestalt-therapist, facing this demand and how the person who attacks his own life is seen. That said, the role of the Gestalt-therapist with the management of suicide situations is highlighted, enabling an opening to listen to the death wish, acting in a way to carry out ethical, political and anthropological deviations, as well as welcoming the suffering of the consultants for the joint creation of new possibilities for the future beyond death. Therefore, the importance of the ethical-political commitment of the professional psychologist is highlighted in the face of the subject's suffering in the face of suicide.Keywords: Gestalt-Therapy; Suicide; Psychological clinic.
Morbidade Hospitalar por Insuficiência Cardíaca no Nordeste Brasileiro (2010-2014) / Hospital Morbidity for Cardiac Insufficiency in Northeastern Brazil (2010-2014)
Authors: Lima Leandro Januário de , Ferreira Victor Emanuel Pereira , Lima Talles Tavares , Batista Hermes Melo Teixeira , Araújo Solange Kelly Lima , Farias Maria do Carmo Andrade Duarte de , Carmo Rondinelle Alves do 
Published: January 2022

Resumo: O Objetivo foi analisar o perfil de morbidade das internações por Insuficiência Cardíaca na região Nordeste do Brasil e sua relação com as variáveis sociodemográficas. Método: Estudo Ecológico compreendendo o período de 2010 a 2014. Os dados foram retirados do Sistema de Informações Hospitalares do Sistema Único de Saúde. Resultados: No período analisado, foram realizadas 297.751 internações por Insuficiência Cardíaca. A taxa padronizada por 100.000 habitantes sofreu redução em todos os Estados. Quando considerado apenas o número bruto de hospitalizações, alguns Estados tiveram pequena redução ou aumento nos casos. O sexo masculino (53,65%), com 60 anos ou mais (68,78%), atendidos em regime de urgência (94,57%) e no setor público (56,21%), de cor parda (44,6%), foi o predominante. Na maioria das faixas etárias o domínio foi do sexo masculino. Conclusão: Embora haja tendência de queda, ainda são altas as prevalências de hospitalização por Insuficiência Cardíaca nos Estados nordestinos. Palavras-chave: Insuficiência Cardíaca; Perfil de Saúde; Hospitalização; Morbidade; Epidemiologia. Abstract: The objective was analyze the morbidity profile of hospitalizations for heart failure in the Northeast region of Brazil and its relationship with sociodemographic variables. Method: Ecological Study covering the period from 2010 to 2014. Data were taken from the Hospital Information System of the Unified Health System. Results: During the analyzed period, 297,751 admissions due to Heart Failure were carried out. The standardized rate per 100,000 inhabitants was reduced in all states. When considering only the gross number of hospitalizations, some states had a small reduction or increase in cases. Predominance in cases involved: Males (53.65%), aged 60 years or more (68.78%), treated in an emergency room (94.57%) and in the public sector (56.21%), brown (44, 6%). In most age groups the domain was male. Conclusion: Although there is a downward trend, the prevalence of hospitalization due to heart failure is still high in the northeastern states.Keywords: Heart Failure. Health Profile. Hospitalization. Morbidity. Epidemiology.