bluuebunny/crossref_metadata_2025_split huggingface dataset:
The bibliometric analysis showed a constantly increasing trend of Rho signaling pathway and the nervous system
Authors: Chen Yangyang , Wang Qing , Yin Junjun , Yuan Shuwen , Wu Yige , Song Lijuan , Huang Jianjun , Yan Yuqing , Ma Cungen 
Published: April 2022

Abstract
Background and aims: The Rho signaling pathway is related to multiple processes in the physiology and pathology of various cells in CNS such as neurons and glial cells and associats with multiple neurological disorders. Fasudil can reduce neurological damage by inhibiting the Rho signaling pathway. We hope to use the method of bibliometric analysis to organize and analyze the literature in related fields, summarize the developed process, and predict the developing trend. Methods: We searched the WOSWeb of Science Core Collection for articles published in English between 2001 and 5 January 2022. VOSviewer is used to process the publication years, countries, citations, authors and keywords of the documents to make a visual map. Results: In the end we got 1413 retrieval results. The results showed that the publication volume of "rho signaling pathway and nervous system" is in a fluctuating development, but the research related to fasudil is relatively slow, and there is still a lot of room for development. Most of the literature types are Article and Review, accounting for more than 90%. Journal of neuroscience has a higher enthusiasm for the research field and has the greatest combined impact. Japan is a country that has carried out related research earlier, but the United States has carried out the most research and contributed the most in related fields. In recent years, China's enthusiasm for related research has gradually increased. Yamashita T published the most literature,. In recent years, the focus of scholars' attention has gradually tended to the two major research directions of "ROCK and neurodegeneration-related diseases" and "multiple neural cell damage". Conclusions: Through the above-mentioned analysis, we found that the research on the Rho signaling pathway and the nervous system is still in the early stage of development, and there is great potential for the development. In particular, the development and clinical application of therapeutic methods and drugs for various neurological diseases will be a research hotspot in the future. We hope that interested scholars can intuitively and clearly understand the existing research results and trends, and provide direction and basis for their future research.
Tailoring ion sieving in graphene oxide membranes with high flux by rational intercalating crown ethers
Authors: Lv Yinjie , Dong Lei , Cheng Lvyang , Gao Tianyi , Wu Cong , Chen Xin , Cui Yuanyuan , Liu Wei 
Published: April 2022

Abstract
Two-dimensional (2D) materials-based membranes are extremely promising for ion-selective separation. However, the permeability-selectivity trade-off for 2D membranes limit their development. Herein, we report a precise tailoring of monovalent cation sieving technology with enhanced water throughput, by the use of graphene oxide (GO) membranes with various crown ether intercalations. The enhanced water-flux of the membranes is due to the expansion of GO interlayers by intercalating crown ethers. We also reveal a systematic study on the limit interlayer size for ion-selective transport in the GO laminas. As a result, remarkably high ion selectivity for different specific cations could be achieved, which is mainly ascribed to the chelation between selective ions and crown ether in the GO laminates. This work opens up a new avenue on precisely regulating ion separations for various application scenarios.
Proteomic Analysis and Comparison of Protein in Tibetan pork and Ordinary pork using TMT-coupled LC-MS/MS
Authors: Wang Lin , Liu Liu , Liu Yongfeng , Zhou Xiaotong , Chi Fumin 
Published: April 2022

Abstract
The objective of this study was to comparatively analyze protein of Tibetan pork and ordinary pork using liquid chromatography tandem-mass spectrometry (LC − MS/MS) combined with tandem mass tag (TMT) labeling. The results showed that 2447 proteins were identified and 249 proteins were significantly changed including 165 significantly up-regulated and 84 significantly down-regulated proteins. The more abundant proteins of Tibetan pork included NADH dehydrogenase, Pyruvate dehydrogenase E1, Very long-chain specific acyl-CoA dehydrogenase, ATPase inhibitor and Cytochrome b-c1 complex subunit 7, which were up-regulated. A Gene Ontology (GO) analysis showed that these proteins mainly participated in biological process, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and the Clusters of Orthologous Groups of proteins (COG) analysis showed that they may be related to energy metabolism and conversion pathway of metabolism process. According to the protein-protein interaction (PPI) analysis, these proteins interacted significantly. This study revealed the Tibetan pork’s advantages in the aspects of energy metabolism compared with ordinary pork at the protein levels.
Ivermectin is associated with increase in SPO2 in hypoxemic SARS-Cov-2 patients: pharmacodynamic profile and correlates.
Authors: Babalola olufemi Emmanuel , Ajayi Adesuyi A. , Yunusa Thairu , Ndanusa Yahaya , Ogedengbe John O. , Ogu Omede 
Published: April 2022

Abstract
Background and Objectives: Hypoxemic respiratory failure is a common mode of demise in Covid 19 disease. We aimed to describe the time course of SPO2 changes in Covid 19 patients treated with and without ivermectin.Methods: This was a parallel group, prospective comparative study of propensity matched Covid 19 patients (Cycle threshold Ct < 25, SPO2 < 94%). 21 of the patients received Ivermectin (IVM) inclusive regime at 12 mg daily for 5 days, while 26 others received Non-ivermectin inclusive regime ( NIVM).Results: the IVM group demonstrated earlier and greater increase in SPO2 (p=0.000) which paralleled greater and faster virological clearance (p = 0.000) on Repeat measures Analysis of Variance RMANOVA. There was a significant correlation between absolute SPO2 and absolute Ct on day 5 (r = 0.77 ) and day 7 (r = 0.77) both p = 0.000. Incremental SPO2 also correlated with incremental Ct. by day 5 ( r = 0.397, p = 0.003) and day 7 ( r = 0.315 , p = 0.0002) relative to baseline. Increase in platelet count correlated with increased SPO2 (r = 0.252, p = 0.029) on IVM, but negatively with NIVM (r = - 0.28, p = 0 .17). Inflammatory markers such as ESR, CRP or D- dimer showed no significant correlation with SPO2. Increase in SPO2 on IVM was magnified in males.Conclusion: IVM regime appears to be associated with faster and greater increase in SPO2 paralleling faster viral clearance in Covid 19 patients.
Association of Marital Status and Access to Dental Care: Cross-sectional study of the Japanese population
Authors: Zaitsu Takashi , Inoue Yuko , Oshiro Akiko , Ishimaru Miho , Taira Kento , Takahashi Hideto , Aida Jun , Tamiya Nanako 
Published: April 2022

Abstract
Background: Health disparities according to marital status have been reported worldwide. Although spouses provide an important social network that influences heath behaviors, limited studies have examined the association between marital status and access to dental care. Therefore, this study aimed to analyze the association between marital status and access to dental care.Methods: This study performed a secondary analysis of a national survey, the 2013 Comprehensive Survey of Living Conditions in Japan. Out of 367,766 respondents, 4,111 respondents, who aged over 40 years and selected oral symptoms as their most concerning subjective symptom were recruited as participants. The independent variable of interest was marital status, married or non-married (single, divorced, widowed); the dependent variable was access to dental care. We performed Poisson regression analyses stratified by sex with adjustment for age, educational status, employment, equivalent household expenditure, and smoking habits.Results: Among respondents who reported oral symptoms, 3,024 were married, and 1,087 were non-married. Further, 29.4% and 40.4% of married and non-married men, respectively, did not receive dental treatment for their symptoms. Meanwhile, 27.5% and 25.0% of married and non-married women, respectively, did not receive dental treatment for their symptoms. The prevalence ratio for not receiving dental treatment was significantly higher among non-married men (Prevalence Ratio: 1.33; 95% Confidence Interval: 1.14–1.56) than among married men. However, no significant association was observed among women. Conclusions: Non-married men were highly likely to not receive dental treatment than married men, while no significant association was observed among women. The results implicate the importance of public dental health policy for protecting health of non-married individuals
Exploring the role of Henry’s law constant in formulating two-parameter linear free energy relationships for facile prediction of lipid-water partition coefficients of neutral organic chemicals
Authors: Khawar Muhammad Irfan , Mahmood Azhar , Nabi Deedar 
Published: April 2022

Abstract
Partition coefficients for storage lipid-water (logKlw) and phospholipid-water (logKpw) phases are key parameters to understand the bioaccumulation and toxicity of organic contaminants. However, the published experimental databases of these properties are dwarfs and current estimation approaches are cumbersome. Here, we present partition models that exploit the correlations of logKlw, and of logKpw with the linear combinations of the octanol-water partition coefficient (logKow) and the dimensionless Henry’s law constant (air-water partition coefficient, logKaw). The calibrated partition models successfully describe the variations in logKlw data (n = 305, R2 = 0.971, root-mean-square-error (rmse) = 0.375), and in logKpw data (n = 131, R2 = 0.953, rmse = 0.413). With the inputs of logKow and logKaw estimated from the U.S. EPA’s EPI Suite™, our models of logKlw and logKpw have exhibited rmse = 0.52 with respect to experimental values indicating suitability of these models for inclusion in the EPI Suite™. Our models perform similar to or better than the previously reported models such as one parameter partition models, Abraham solvation models, and models based on quantum-chemical calculations. Taken together, our models are robust, easy-to-use, and provide insight about variations of logKlw and logKpw in terms of hydrophobicity and volatility trait of chemicals.
Behaviors of Nanocomposite Mg-Alloy in Simulated Bodily Fluids and pH Fluctuations
Authors: El-Sherif Rabab M. , Zohdy K. M. , El-Shamy A. M. 
Published: April 2022

Abstract
Its biodegradability, non-poisonousness, and exceptional natural and machinery features make Mg and its components attractive alternatives for biomedical implantation supplies, according to the National Institute of Health. SBF is used as a standard electrolyte for in vitro corrosion research. Each SBF module's independent and synergistic corrosion effects are studied in this study. Artificial pH variations increase degradation, according to the results. This experiment examined the Mg corrosion submerged in a simulated bodily fluid (SBF) solution. The effect of pH changes on the rate of corrosion of Mg immersed in standard SBF solution was investigated. According to the previously published study, the corrosion process of Mg has been confirmed by scanning electron microscopy observations of damaged surface morphology (SEM). Because of these investigations, pH 7 was selected as the pH for bodily fluids since it is neutral.
The Reliability, Validity and Screening Effect of the Happiness Index Scale among inpatients in a General Hospital
Authors: Shen Yizhong , Yuan Shuai , Liu Jingwen , Sun Bin , Chen Zilin , Zheng Lijiao , Chen Lihao , Chen Hanwei , Feng Huiqiang , Hongbo He 
Published: April 2022

Abstract
Background
The Happiness Index Scale (HIS) is a newly developed scale by our group to screen for common psychological illnesses among general hospital inpatients. This study aimed to analyze the reliability, validity and screening effect of the HIS and to explore its clinical application.
Methods
From April 1, 2021, to December 31, 2021, a total of 8405 continuous inpatients were enrolled from different departments of a large tertiary general hospital with 1385 inpatient beds in Guangzhou, Guangdong Province, China. Using a cross-sectional survey design, each participant was assessed with the Patient Health Questionnaire 9(PHQ-9), Generalized Anxiety Disorder 7 items(GAD-7), Athens Insomnia Scale (AIS), Columbia Suicide Severity Rating Scale (C-SSRS) and HIS within 24 hours of admission. Cronbach's α coefficient, the Guttman split-half coefficient and the test-retest reliability coefficient were used to evaluate the reliability of the HIS and the construct validity and criterion validity of the validity tests. Scores on the PHQ-9, GAD-7, AIS, and C-SSRS were used as the gold standard tools to analyze the screening effect of the HIS.
Results
The HIS exhibited very good reliability, with a Cronbach's α coefficient of 0.824, a Guttman split-half coefficient of 0.920 and a test-retest reliability coefficient of 0.745 (P < 0.05). Confirmatory factor analysis showed a high model fitting index with a χ²/df = 5.838, a root mean squared error of approximation (RMSEA) of 0.024, a goodness-of-fit index (GFI) of 0.998, an adjusted goodness-of-fit index (AGFI) of 0.994, a comparative fit index (CFI) of 0.998, an incremental fit index (IFI) of 0.998, and a Tucker–Lewis index (TLI) of 0.996. The correlation coefficient between the total score of each dimension of the scale and the corresponding criterion was 0.854 ~ 0.949 (P < 0.001). The HIS showed a very good distinguishing effect. The average HIS score of inpatients who screened positive for psychological problems was significantly higher than that of inpatients who screened negative for psychological problems (Z = 479099.000, P < 0.001). The effect size was very large (Cohens d = 2.227, 95% CI = 2.166 ~ 2.289). Approximately 90.2% of the positive and negative screening results of the HIS were matched with the gold standard tools, with a kappa value of 0.747 (P < 0.001). The screening effect test showed a sensitivity (true positive rate) of 92.9% and a specificity (true negative rate) of 89.5%.
Conclusion
The HIS exhibited relatively high reliability and validity and a clinically meaningful screening effect with a much shorter version compared to the commonly used screening scales. Thus, it could potentially be useful as the first screening step to rule out psychological conditions for inpatients in general hospitals or to remind medical teams of further psychological concerns.
The Updated Consolidated Framework for Implementation Research: CFIR 2.0
Authors: Damschroder Laura , Reardon Caitlin M. , Widerquist Marilla A. Opra , Lowery Julie C. 
Published: April 2022

Abstract
BackgroundMany implementation efforts fail, even with highly developed plans for execution, because contextual factors can be powerful forces working against implementation in the real-world. The Consolidated Framework for Implementation Research (CFIR) is one of the most commonly used determinant frameworks to assess these contextual factors, however, it has been 10 years since publication and there is a need for updates. The purpose of this manuscript is to describe the updated CFIR 2.0, which addresses important user critiques of the framework.MethodsUser feedback was obtained from two sources: 1) a literature review with a systematic search; and 2) a survey of authors who used the CFIR 2009 in a published study. Data were combined across both sources and reviewed to identify themes; a consensus approach was used to finalize all CFIR 2.0 updates. The VA Ann Arbor Healthcare System IRB declared this study exempt from the requirements of 38 CFR 16 based on category 2. ResultsThe systematic search yielded 376 articles and 334 unique authors with contact information; 59 articles included feedback on the CFIR. Forty percent (n=134/334) of authors responded to the survey. The CFIR received positive ratings on most framework sensibility items, e.g., applicability, usability, but respondents also provided recommendations for changes. Overall, updates to the CFIR 2.0 include revisions to existing constructs as well as the addition, removal, or relocation of constructs. These changes serve to facilitate use of the CFIR, address gaps in themes, and better center recipients. ConclusionThe updates in the CFIR 2.0 reflect feedback from the growing community of CFIR users; although there are many updates, constructs can be mapped back to the CFIR 2009 to ensure longitudinal consistency. We invite users to continuing critiquing the framework in order it continue to evolve.
Doxorubicin-liposome combined with clodronate-liposome inhibits hepatocellular carcinoma through the depletion of macrophages and tumor cells
Authors: Zhang Li , Zhang Hengyan , Sheng Dandan , Hou Xiaojuan , Sun Gangqi , Zhang Luyao , Yang Xue , Wang Xinxia , Wei Lixin , Lu Ying , Han Zhipeng 
Published: April 2022

Abstract
Background: Macrophages in the liver have capacities of capturing and phagocytosing nanocarriers and play an important role in inflammatory microenvironment and hepatocellular carcinoma (HCC) initiation and progression. Depletion of macrophages might be a feasible strategy for drug delivery and tumor microenvironment modulation during HCC. Methods: To verify this hypothesis, liposomes targeting macrophages containing DOX and clodronate were prepared using ammonium sulfate gradient and thin film hydration method. Then liposomes were given to rats at different stages of diethylnitrosamine (DEN) induced primary HCC model to understand the preventive and therapeutic effects of the liposomes. Results: Doxorubicin-liposome (Doxil) and clodronate-liposome (CL-LIP) about 180-200 nm were successfully prepared and characterized, with a polydispersity index of <0.3 and free doxorubicin (DOX) encapsulation efficacy of >97%. We found that Doxil combined with CL-LIP could effectively target and eliminate macrophages in the liver, releasing DOX into plasma and inhibiting HCC in vivo.Conclusions: DOX and clodronate-loaded liposomes targeting macrophages can effectively reduce macrophages phagocytosis, concentrate DOX in the plasma and accumulate DOX in the liver and spleen for a longer time, improving tumor microenvironment and restraining activation of hepatic progenitor cells (HPCs), thus enhance the inhibition and therapeutic effects against HCC in rats. Results of this study were expected to provide a new prospect for the chemotherapy of HCC.
Influence of fatty acid composition and aroma components on the flavor of green onion (Allium fistulosum L.) deep-fried oil
Authors: Liu Bing , Wang Ruifang , Chang Yuan , Liu Zixuan , Wang Shuqi , Sun Jie , Chen Haitao , Sun Baoguo , Zhang Ning 
Published: April 2022

Abstract
This paper aimed to explore the effects of different varieties of oils on the volatile flavor compounds and fatty acid composition of green onion deep-fried oils, and establish the flavor fingerprints of different green onion deep-fried oils. The volatile flavor compounds and fatty acids in 7 kinds of green onion deep-fried oils were identified and analyzed by electronic nose and gas chromatography-mass spectrometry (GC-MS). The results showed that sensory evaluations and electronic nose were accepted to detect the odor differences of different kinds of green onion deep-fried oils sensitively. 103 volatile flavor components were identified positively by GC-MS, and the key aroma compounds including aldehydes and sulfur-containing compounds that correlated highly with green, grease, pungent and shallot scent attributes. The fatty acid detection showed that there was not significant change in the types of fatty acids, but the relative content is different evidently after frying process. The unsaturated fatty acids (UFA, C18:1, C18:2, C18:3, and C20:1) had a significant influence on the flavor of frying oil, which were peculiarly prone to oxidation and heat-degradability reaction. These results had a positive impact on the development of deep-fried oil products and technology to differentiate between true and false deep-fried oil.
A Kilonova Following a Long-Duration Gamma-Ray Burst at 350 Mpc
Authors: Rastinejad Jillian , Gompertz Benjamin , Levan Andrew , Fong Wen-fai , Nicholl Matt , Lamb Gavin , Malesani Daniele , Nugent Anya , Oates Samantha , Tanvir Nial , Postigo Antonio de Ugarte , Kilpatrick Charles , Moore Christopher , Metzger Brian , Ravasio Maria Edvige , Rossi Andrea , Schroeder Genevieve , Jencson Jacob , Sand David , Smith Nathan , Fernández José Feliciano Agüí , Berger Edo , Blanchard Peter , Chornock Ryan , Cobb Bethany , De Pasquale Massimiliano , Fynbo Johan , Izzo Luca , Kann David Alexander , Laskar Tanmoy , Marini Ester , Paterson Kerry , Escorial Alicia Rouco , Sears Huei , Thöne Christina 
Published: April 2022

Abstract
Gamma-ray bursts (GRBs) are divided into two populations [1, 2]; long GRBs that derive from the core-collapse of massive stars [e.g., 3] and short GRBs that form in the merger of two compact objects [4]. While it is common to divide the two populations at a γ-ray duration of two seconds, classification based on duration does not always cleanly map to the progenitor. This is notable in the form of GRBs with bright, GRB 211211A 3 short (≲ 2 seconds) spikes of prompt γ-ray emission followed by more prolonged, spectrally-softer extended emission (EE-SGRBs), which have been suggested to arise from compact object mergers [5–7]. Compact object mergers are of great astrophysical importance as the only confirmed site of rapid neutron capture (r-process) nucleosynthesis, observed in the form of so-called kilonovae [8–13]. Here, we report the discovery of a kilonova associated with a nearby (350 Mpc) minute-duration GRB, confirming that the progenitor is a compact object merger. This kilonova has a similar luminosity, duration and color to AT 2017gfo, the kilonova found in association with the gravitational wave (GW)-detected binary neutron star (BNS) merger GW170817 [4]. We find that the merger ejected ≈ 0.04M⊙ of r-process-rich material, and is consistent with the merger of two neutron stars (NSs) with masses close to the canonical 1.4M⊙. This discovery implies that GRBs with long, complex light curves can be spawned from compact object merger events and that a population of kilonovae following GRBs with durations ≫ 2 s should be accounted for in calculations of the NS merger r-process contribution. At 350 Mpc, the current network of GW interferometers at design sensitivity would have detected the merger precipitating GRB 211211A, had it been operating at the time of the event. Further searches for GW signals coincident with long GRBs are a promising route for future multi-messenger astronomy.